id author title date pages extension mime words sentences flesch summary cache txt cord-283378-brdtsi65 Maragkoudakis, Petros A. Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection 2010-07-31 .txt text/plain 5024 209 47 This study aimed to examine the potential antiviral activity of lactic acid bacteria (LAB) using animal and human intestinal and macrophage cell line models of non tumor origin. Highest protection effects were recorded with the known probiotics Lactobacillus rhamnosus GG and Lactobacillus casei Shirota against both RV and TGEV, while notable antiviral activity was also attributed to Enterococcus faecium PCK38, Lactobacillus fermentum ACA-DC179, Lactobacillus pentosus PCA227 and Lactobacillus plantarum PCA236 and PCS22, depending on the cell line and virus combination used. Additional functional properties that relate to the possible underlying mode of action of the antiviral effect have been also studied, including release of reactive oxygen species (ROS) from the cell lines due to probiotic interaction, as well as the attachment ability of probiotic strains on the cell line monolayers. Recent studies (Botić et al., 2007; Ivec et al., 2007) reported the protective effect that various lactic acid bacteria, including the probiotic Lactobacillus paracasei F19, conferred upon porcine intestinal epithelial and macrophage cell line infected with vesicular stomatitis virus (VSV). ./cache/cord-283378-brdtsi65.txt ./txt/cord-283378-brdtsi65.txt