id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287602-vda01gj6	Jin, Yu-Bei	Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets	2018-07-18		.txt	text/plain	6329	303	50	In this study, we constructed a suite of recombinant Lactobacillus plantarum with surface displaying the spike (S) protein coming from TGEV and fused with DC cells targeting peptides (DCpep) to develop an effective, safe, and convenient vaccine against transmissible gastroenteritis. Our research results found that the recombinant Lactobacillus plantarum (NC8-pSIP409-pgsA-S-DCpep) group expressing S fused with DCpep could not only significantly increase the percentages of MHC-II(+)CD80(+) B cells and CD3(+)CD4(+) T cells but also the number of IgA(+) B cells and CD3(+)CD4(+) T cells of ileum lamina propria, which elevated the specific secretory immunoglobulin A (SIgA) titers in feces and IgG titers in serum. Therefore, in this study, we mainly researched the effects of recombinant lactic acid bacteria NC8-pSIP409-pgsA-S-DCpep expressing DCpep and target antigen S protein on MHC-II + CD80 + B cells, CD3 + CD4 + cells related to mucosal immune responses, and anti-TGEVspecific antibodies.	./cache/cord-287602-vda01gj6.txt	./txt/cord-287602-vda01gj6.txt