id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346872-k5d5793a	Yuan, Peng	Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH	2018-09-03		.txt	text/plain	5626	295	51	Both viruses establish an infection in porcine enterocytes in the small intestine, and their spike (S) proteins play a key role in the virus-cell binding process under unfavorable conditions when the intestine with a low pH is filled with a thick layer of mucus and proteases. This review emphasizes the role of three factors (sialic acid, proteases, and low pH) in the invasion of TGEV and PEDV into porcine small intestine epithelial cells and provides information with respect to α-CoV infection that brings new insights into virus research. Like TGEV, the crystal structure of a single domain unit in the PRCoV RBD adopts a β-barrel fold with 2 highly twisted β-sheets located in the CTD of the S1 domain and engages in binding to the host cell surface receptor. Low pH in the initial stage of PEDV entry into intestinal epithelial cells allows structural changes and protease activation during binding to surface receptors.	./cache/cord-346872-k5d5793a.txt	./txt/cord-346872-k5d5793a.txt