id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012349-wutnt8yk	Lech, Karolina	Investigation of metabolites for estimating blood deposition time	2017-08-05		.txt	text/plain	3287	154	43	In a proof-of-principle study, we previously introduced the concept of molecular trace deposition timing, i.e. to establish the day/night time when (not since) a biological sample was placed at the crime scene, by measuring two circadian hormones, melatonin and cortisol, in small amounts of blood and saliva, and demonstrated that the established rhythmic concentration pattern of both biomarkers can be observed in such forensic-type samples [9] . Recently, we identified various rhythmically expressed genes in the blood [10] and subsequently demonstrated the suitability of such messenger RNA (mRNA) biomarkers for blood trace deposition timing by establishing a statistical model based on melatonin, cortisol and three mRNA biomarkers for predicting three day/night time categories: morning/noon, afternoon/evening and night/early morning [11] . In this forensically motivated metabolomics study, 56 metabolite biomarkers exhibiting significant daily rhythms in concentration were identified in plasma and were further investigated for their suitability for estimating blood trace deposition time.	./cache/cord-012349-wutnt8yk.txt	./txt/cord-012349-wutnt8yk.txt