id sid tid token lemma pos cord-005687-gj6q0ft0 1 1 key key NN cord-005687-gj6q0ft0 1 2 : : : cord-005687-gj6q0ft0 2 1 cord-005687-gj6q0ft0 cord-005687-gj6q0ft0 PRP$ cord-005687-gj6q0ft0 2 2 authors author NNS cord-005687-gj6q0ft0 2 3 : : : cord-005687-gj6q0ft0 2 4 Paiva Paiva NNP cord-005687-gj6q0ft0 2 5 , , , cord-005687-gj6q0ft0 2 6 José José NNP cord-005687-gj6q0ft0 2 7 - - HYPH cord-005687-gj6q0ft0 2 8 Artur Artur NNP cord-005687-gj6q0ft0 2 9 ; ; : cord-005687-gj6q0ft0 2 10 Laupland Laupland NNP cord-005687-gj6q0ft0 2 11 , , , cord-005687-gj6q0ft0 2 12 Kevin Kevin NNP cord-005687-gj6q0ft0 2 13 B. B. NNP cord-005687-gj6q0ft0 2 14 title title NN cord-005687-gj6q0ft0 2 15 : : : cord-005687-gj6q0ft0 2 16 Real real JJ cord-005687-gj6q0ft0 2 17 -time -time HYPH cord-005687-gj6q0ft0 2 18 PCR PCR NNP cord-005687-gj6q0ft0 2 19 for for IN cord-005687-gj6q0ft0 2 20 early early JJ cord-005687-gj6q0ft0 2 21 microbiological microbiological JJ cord-005687-gj6q0ft0 2 22 diagnosis diagnosis NN cord-005687-gj6q0ft0 2 23 : : : cord-005687-gj6q0ft0 2 24 is be VBZ cord-005687-gj6q0ft0 2 25 it -PRON- PRP cord-005687-gj6q0ft0 2 26 time time NN cord-005687-gj6q0ft0 2 27 ? ? . cord-005687-gj6q0ft0 3 1 date date NN cord-005687-gj6q0ft0 3 2 : : : cord-005687-gj6q0ft0 3 3 2017 2017 CD cord-005687-gj6q0ft0 3 4 - - HYPH cord-005687-gj6q0ft0 3 5 05 05 CD cord-005687-gj6q0ft0 3 6 - - HYPH cord-005687-gj6q0ft0 3 7 23 23 CD cord-005687-gj6q0ft0 3 8 journal journal NN cord-005687-gj6q0ft0 3 9 : : : cord-005687-gj6q0ft0 3 10 Intensive Intensive NNP cord-005687-gj6q0ft0 3 11 Care care NN cord-005687-gj6q0ft0 3 12 Med Med NNP cord-005687-gj6q0ft0 3 13 DOI doi NN cord-005687-gj6q0ft0 3 14 : : : cord-005687-gj6q0ft0 3 15 10.1007 10.1007 CD cord-005687-gj6q0ft0 3 16 / / SYM cord-005687-gj6q0ft0 3 17 s00134 s00134 VBN cord-005687-gj6q0ft0 3 18 - - HYPH cord-005687-gj6q0ft0 3 19 017 017 CD cord-005687-gj6q0ft0 3 20 - - HYPH cord-005687-gj6q0ft0 3 21 4793 4793 CD cord-005687-gj6q0ft0 3 22 - - SYM cord-005687-gj6q0ft0 3 23 1 1 CD cord-005687-gj6q0ft0 3 24 sha sha NNP cord-005687-gj6q0ft0 3 25 : : : cord-005687-gj6q0ft0 4 1 d2669e2b1e5c7bd803087f7e04dbf45a360b4de8 d2669e2b1e5c7bd803087f7e04dbf45a360b4de8 NNP cord-005687-gj6q0ft0 4 2 doc_id doc_id CD cord-005687-gj6q0ft0 4 3 : : : cord-005687-gj6q0ft0 5 1 5687 5687 CD cord-005687-gj6q0ft0 5 2 cord_uid cord_uid NN cord-005687-gj6q0ft0 5 3 : : : cord-005687-gj6q0ft0 6 1 gj6q0ft0 gj6q0ft0 XX cord-005687-gj6q0ft0 6 2 nan nan NNP cord-005687-gj6q0ft0 6 3 Blood Blood NNP cord-005687-gj6q0ft0 6 4 cultures culture NNS cord-005687-gj6q0ft0 6 5 are be VBP cord-005687-gj6q0ft0 6 6 the the DT cord-005687-gj6q0ft0 6 7 classical classical JJ cord-005687-gj6q0ft0 6 8 gold gold NN cord-005687-gj6q0ft0 6 9 standard standard NN cord-005687-gj6q0ft0 6 10 for for IN cord-005687-gj6q0ft0 6 11 microbiological microbiological JJ cord-005687-gj6q0ft0 6 12 diagnosis diagnosis NN cord-005687-gj6q0ft0 6 13 of of IN cord-005687-gj6q0ft0 6 14 bloodstream bloodstream NN cord-005687-gj6q0ft0 6 15 infection infection NN cord-005687-gj6q0ft0 6 16 ( ( -LRB- cord-005687-gj6q0ft0 6 17 BSI BSI NNP cord-005687-gj6q0ft0 6 18 ) ) -RRB- cord-005687-gj6q0ft0 6 19 and and CC cord-005687-gj6q0ft0 6 20 sepsis sepsis NN cord-005687-gj6q0ft0 6 21 . . . cord-005687-gj6q0ft0 7 1 However however RB cord-005687-gj6q0ft0 7 2 , , , cord-005687-gj6q0ft0 7 3 only only RB cord-005687-gj6q0ft0 7 4 10 10 CD cord-005687-gj6q0ft0 7 5 % % NN cord-005687-gj6q0ft0 7 6 of of IN cord-005687-gj6q0ft0 7 7 blood blood NN cord-005687-gj6q0ft0 7 8 cultures culture NNS cord-005687-gj6q0ft0 7 9 processed process VBN cord-005687-gj6q0ft0 7 10 are be VBP cord-005687-gj6q0ft0 7 11 positive positive JJ cord-005687-gj6q0ft0 7 12 , , , cord-005687-gj6q0ft0 7 13 and and CC cord-005687-gj6q0ft0 7 14 finalized finalize VBD cord-005687-gj6q0ft0 7 15 results result NNS cord-005687-gj6q0ft0 7 16 typically typically RB cord-005687-gj6q0ft0 7 17 take take VBP cord-005687-gj6q0ft0 7 18 48 48 CD cord-005687-gj6q0ft0 7 19 - - SYM cord-005687-gj6q0ft0 7 20 72 72 CD cord-005687-gj6q0ft0 7 21 h. h. NN cord-005687-gj6q0ft0 7 22 Empirical empirical JJ cord-005687-gj6q0ft0 7 23 antimicrobial antimicrobial JJ cord-005687-gj6q0ft0 7 24 therapy therapy NN cord-005687-gj6q0ft0 7 25 , , , cord-005687-gj6q0ft0 7 26 administered administer VBN cord-005687-gj6q0ft0 7 27 until until IN cord-005687-gj6q0ft0 7 28 the the DT cord-005687-gj6q0ft0 7 29 etiological etiological JJ cord-005687-gj6q0ft0 7 30 agent agent NN cord-005687-gj6q0ft0 7 31 is be VBZ cord-005687-gj6q0ft0 7 32 identified identify VBN cord-005687-gj6q0ft0 7 33 and and CC cord-005687-gj6q0ft0 7 34 antimicrobial antimicrobial JJ cord-005687-gj6q0ft0 7 35 susceptibility susceptibility NN cord-005687-gj6q0ft0 7 36 test test NN cord-005687-gj6q0ft0 7 37 results result NNS cord-005687-gj6q0ft0 7 38 are be VBP cord-005687-gj6q0ft0 7 39 available available JJ cord-005687-gj6q0ft0 7 40 , , , cord-005687-gj6q0ft0 7 41 may may MD cord-005687-gj6q0ft0 7 42 be be VB cord-005687-gj6q0ft0 7 43 either either CC cord-005687-gj6q0ft0 7 44 excessive excessive JJ cord-005687-gj6q0ft0 7 45 or or CC cord-005687-gj6q0ft0 7 46 inadequate inadequate JJ cord-005687-gj6q0ft0 7 47 , , , cord-005687-gj6q0ft0 7 48 and and CC cord-005687-gj6q0ft0 7 49 unnecessary unnecessary JJ cord-005687-gj6q0ft0 7 50 treatment treatment NN cord-005687-gj6q0ft0 7 51 with with IN cord-005687-gj6q0ft0 7 52 broadspectrum broadspectrum NNP cord-005687-gj6q0ft0 7 53 antimicrobials antimicrobial NNS cord-005687-gj6q0ft0 7 54 can can MD cord-005687-gj6q0ft0 7 55 lead lead VB cord-005687-gj6q0ft0 7 56 to to IN cord-005687-gj6q0ft0 7 57 significant significant JJ cord-005687-gj6q0ft0 7 58 collateral collateral JJ cord-005687-gj6q0ft0 7 59 damage damage NN cord-005687-gj6q0ft0 7 60 including include VBG cord-005687-gj6q0ft0 7 61 drug drug NN cord-005687-gj6q0ft0 7 62 toxicity toxicity NN cord-005687-gj6q0ft0 7 63 , , , cord-005687-gj6q0ft0 7 64 antimicrobial antimicrobial JJ cord-005687-gj6q0ft0 7 65 drug drug NN cord-005687-gj6q0ft0 7 66 resistance resistance NN cord-005687-gj6q0ft0 7 67 , , , cord-005687-gj6q0ft0 7 68 increased increase VBN cord-005687-gj6q0ft0 7 69 length length NN cord-005687-gj6q0ft0 7 70 of of IN cord-005687-gj6q0ft0 7 71 stay stay NN cord-005687-gj6q0ft0 7 72 , , , cord-005687-gj6q0ft0 7 73 and and CC cord-005687-gj6q0ft0 7 74 additional additional JJ cord-005687-gj6q0ft0 7 75 cost cost NN cord-005687-gj6q0ft0 7 76 . . . cord-005687-gj6q0ft0 8 1 This this DT cord-005687-gj6q0ft0 8 2 is be VBZ cord-005687-gj6q0ft0 8 3 an an DT cord-005687-gj6q0ft0 8 4 important important JJ cord-005687-gj6q0ft0 8 5 and and CC cord-005687-gj6q0ft0 8 6 relevant relevant JJ cord-005687-gj6q0ft0 8 7 quality quality NN cord-005687-gj6q0ft0 8 8 gap gap NN cord-005687-gj6q0ft0 8 9 . . . cord-005687-gj6q0ft0 9 1 It -PRON- PRP cord-005687-gj6q0ft0 9 2 is be VBZ cord-005687-gj6q0ft0 9 3 evident evident JJ cord-005687-gj6q0ft0 9 4 that that IN cord-005687-gj6q0ft0 9 5 improved improve VBN cord-005687-gj6q0ft0 9 6 identification identification NN cord-005687-gj6q0ft0 9 7 methods method NNS cord-005687-gj6q0ft0 9 8 and and CC cord-005687-gj6q0ft0 9 9 practices practice NNS cord-005687-gj6q0ft0 9 10 that that WDT cord-005687-gj6q0ft0 9 11 allow allow VBP cord-005687-gj6q0ft0 9 12 reduction reduction NN cord-005687-gj6q0ft0 9 13 of of IN cord-005687-gj6q0ft0 9 14 time time NN cord-005687-gj6q0ft0 9 15 to to IN cord-005687-gj6q0ft0 9 16 microbiological microbiological JJ cord-005687-gj6q0ft0 9 17 diagnosis diagnosis NN cord-005687-gj6q0ft0 9 18 and and CC cord-005687-gj6q0ft0 9 19 targeted target VBN cord-005687-gj6q0ft0 9 20 therapy therapy NN cord-005687-gj6q0ft0 9 21 constitutes constitute VBZ cord-005687-gj6q0ft0 9 22 a a DT cord-005687-gj6q0ft0 9 23 major major JJ cord-005687-gj6q0ft0 9 24 quality quality NN cord-005687-gj6q0ft0 9 25 improvement improvement NN cord-005687-gj6q0ft0 9 26 framework framework NN cord-005687-gj6q0ft0 9 27 in in IN cord-005687-gj6q0ft0 9 28 antibiotic antibiotic JJ cord-005687-gj6q0ft0 9 29 use use NN cord-005687-gj6q0ft0 9 30 [ [ -LRB- cord-005687-gj6q0ft0 9 31 1 1 CD cord-005687-gj6q0ft0 9 32 ] ] -RRB- cord-005687-gj6q0ft0 9 33 . . . cord-005687-gj6q0ft0 10 1 Diagnostic diagnostic JJ cord-005687-gj6q0ft0 10 2 techniques technique NNS cord-005687-gj6q0ft0 10 3 that that WDT cord-005687-gj6q0ft0 10 4 do do VBP cord-005687-gj6q0ft0 10 5 not not RB cord-005687-gj6q0ft0 10 6 depend depend VB cord-005687-gj6q0ft0 10 7 on on IN cord-005687-gj6q0ft0 10 8 growth growth NN cord-005687-gj6q0ft0 10 9 of of IN cord-005687-gj6q0ft0 10 10 organisms organism NNS cord-005687-gj6q0ft0 10 11 in in IN cord-005687-gj6q0ft0 10 12 culture culture NN cord-005687-gj6q0ft0 10 13 may may MD cord-005687-gj6q0ft0 10 14 offer offer VB cord-005687-gj6q0ft0 10 15 a a DT cord-005687-gj6q0ft0 10 16 distinct distinct JJ cord-005687-gj6q0ft0 10 17 advantage advantage NN cord-005687-gj6q0ft0 10 18 over over IN cord-005687-gj6q0ft0 10 19 current current JJ cord-005687-gj6q0ft0 10 20 methods method NNS cord-005687-gj6q0ft0 10 21 . . . cord-005687-gj6q0ft0 11 1 They -PRON- PRP cord-005687-gj6q0ft0 11 2 allow allow VBP cord-005687-gj6q0ft0 11 3 shorter short JJR cord-005687-gj6q0ft0 11 4 time time NN cord-005687-gj6q0ft0 11 5 to to IN cord-005687-gj6q0ft0 11 6 results result NNS cord-005687-gj6q0ft0 11 7 and and CC cord-005687-gj6q0ft0 11 8 detection detection NN cord-005687-gj6q0ft0 11 9 of of IN cord-005687-gj6q0ft0 11 10 non non JJ cord-005687-gj6q0ft0 11 11 - - JJ cord-005687-gj6q0ft0 11 12 cultivable cultivable JJ cord-005687-gj6q0ft0 11 13 microorganisms microorganism NNS cord-005687-gj6q0ft0 11 14 under under IN cord-005687-gj6q0ft0 11 15 antibiotic antibiotic JJ cord-005687-gj6q0ft0 11 16 pressure pressure NN cord-005687-gj6q0ft0 11 17 . . . cord-005687-gj6q0ft0 12 1 Two two CD cord-005687-gj6q0ft0 12 2 recent recent JJ cord-005687-gj6q0ft0 12 3 studies study NNS cord-005687-gj6q0ft0 12 4 have have VBP cord-005687-gj6q0ft0 12 5 shown show VBN cord-005687-gj6q0ft0 12 6 that that IN cord-005687-gj6q0ft0 12 7 matrix matrix NN cord-005687-gj6q0ft0 12 8 - - HYPH cord-005687-gj6q0ft0 12 9 assisted assist VBN cord-005687-gj6q0ft0 12 10 laser laser NN cord-005687-gj6q0ft0 12 11 desorption desorption NN cord-005687-gj6q0ft0 12 12 / / SYM cord-005687-gj6q0ft0 12 13 ionization ionization NN cord-005687-gj6q0ft0 12 14 time time NN cord-005687-gj6q0ft0 12 15 - - HYPH cord-005687-gj6q0ft0 12 16 of of IN cord-005687-gj6q0ft0 12 17 - - HYPH cord-005687-gj6q0ft0 12 18 flight flight NN cord-005687-gj6q0ft0 12 19 mass mass NN cord-005687-gj6q0ft0 12 20 spectrometry spectrometry NN cord-005687-gj6q0ft0 12 21 following follow VBG cord-005687-gj6q0ft0 12 22 isolation isolation NN cord-005687-gj6q0ft0 12 23 from from IN cord-005687-gj6q0ft0 12 24 clinical clinical JJ cord-005687-gj6q0ft0 12 25 specimens specimen NNS cord-005687-gj6q0ft0 12 26 coupled couple VBN cord-005687-gj6q0ft0 12 27 with with IN cord-005687-gj6q0ft0 13 1 antimicrobial antimicrobial NNP cord-005687-gj6q0ft0 13 2 stewardship stewardship NN cord-005687-gj6q0ft0 13 3 programme programme NN cord-005687-gj6q0ft0 13 4 ( ( -LRB- cord-005687-gj6q0ft0 13 5 AST AST NNP cord-005687-gj6q0ft0 13 6 ) ) -RRB- cord-005687-gj6q0ft0 13 7 intervention intervention NN cord-005687-gj6q0ft0 13 8 decreases decrease VBZ cord-005687-gj6q0ft0 13 9 time time NN cord-005687-gj6q0ft0 13 10 to to IN cord-005687-gj6q0ft0 13 11 organism organism NN cord-005687-gj6q0ft0 13 12 identification identification NN cord-005687-gj6q0ft0 13 13 and and CC cord-005687-gj6q0ft0 13 14 to to TO cord-005687-gj6q0ft0 13 15 effective effective VB cord-005687-gj6q0ft0 13 16 and and CC cord-005687-gj6q0ft0 13 17 optimal optimal JJ cord-005687-gj6q0ft0 13 18 antibiotic antibiotic JJ cord-005687-gj6q0ft0 13 19 therapy therapy NN cord-005687-gj6q0ft0 13 20 in in IN cord-005687-gj6q0ft0 13 21 adult adult NN cord-005687-gj6q0ft0 13 22 [ [ -LRB- cord-005687-gj6q0ft0 13 23 2 2 CD cord-005687-gj6q0ft0 13 24 ] ] -RRB- cord-005687-gj6q0ft0 13 25 and and CC cord-005687-gj6q0ft0 13 26 pediatric pediatric JJ cord-005687-gj6q0ft0 13 27 patients patient NNS cord-005687-gj6q0ft0 13 28 with with IN cord-005687-gj6q0ft0 13 29 BSI BSI NNP cord-005687-gj6q0ft0 13 30 [ [ -LRB- cord-005687-gj6q0ft0 13 31 3 3 CD cord-005687-gj6q0ft0 13 32 ] ] -RRB- cord-005687-gj6q0ft0 13 33 . . . cord-005687-gj6q0ft0 14 1 In in IN cord-005687-gj6q0ft0 14 2 the the DT cord-005687-gj6q0ft0 14 3 adult adult NN cord-005687-gj6q0ft0 14 4 population population NN cord-005687-gj6q0ft0 14 5 , , , cord-005687-gj6q0ft0 14 6 acceptance acceptance NN cord-005687-gj6q0ft0 14 7 of of IN cord-005687-gj6q0ft0 14 8 an an DT cord-005687-gj6q0ft0 14 9 AST AST NNP cord-005687-gj6q0ft0 14 10 intervention intervention NN cord-005687-gj6q0ft0 14 11 has have VBZ cord-005687-gj6q0ft0 14 12 also also RB cord-005687-gj6q0ft0 14 13 been be VBN cord-005687-gj6q0ft0 14 14 associated associate VBN cord-005687-gj6q0ft0 14 15 with with IN cord-005687-gj6q0ft0 14 16 a a DT cord-005687-gj6q0ft0 14 17 trend trend NN cord-005687-gj6q0ft0 14 18 toward toward IN cord-005687-gj6q0ft0 14 19 reduced reduce VBN cord-005687-gj6q0ft0 14 20 mortality mortality NN cord-005687-gj6q0ft0 14 21 on on IN cord-005687-gj6q0ft0 14 22 multivariable multivariable JJ cord-005687-gj6q0ft0 14 23 analysis analysis NN cord-005687-gj6q0ft0 14 24 . . . cord-005687-gj6q0ft0 15 1 Moreover moreover RB cord-005687-gj6q0ft0 15 2 , , , cord-005687-gj6q0ft0 15 3 nucleic nucleic JJ cord-005687-gj6q0ft0 15 4 acid acid NN cord-005687-gj6q0ft0 15 5 amplification amplification NN cord-005687-gj6q0ft0 15 6 testing testing NN cord-005687-gj6q0ft0 15 7 and and CC cord-005687-gj6q0ft0 15 8 mass mass NN cord-005687-gj6q0ft0 15 9 spectrometry spectrometry NN cord-005687-gj6q0ft0 15 10 can can MD cord-005687-gj6q0ft0 15 11 identify identify VB cord-005687-gj6q0ft0 15 12 selected select VBN cord-005687-gj6q0ft0 15 13 antibiotic antibiotic JJ cord-005687-gj6q0ft0 15 14 resistance resistance NN cord-005687-gj6q0ft0 15 15 patterns pattern NNS cord-005687-gj6q0ft0 15 16 to to IN cord-005687-gj6q0ft0 15 17 vancomycin vancomycin FW cord-005687-gj6q0ft0 15 18 ( ( -LRB- cord-005687-gj6q0ft0 15 19 VanA/ VanA/ NNP cord-005687-gj6q0ft0 15 20 VanB VanB NNP cord-005687-gj6q0ft0 15 21 ) ) -RRB- cord-005687-gj6q0ft0 15 22 , , , cord-005687-gj6q0ft0 15 23 methicillin methicillin FW cord-005687-gj6q0ft0 15 24 ( ( -LRB- cord-005687-gj6q0ft0 15 25 MecA MecA NNP cord-005687-gj6q0ft0 15 26 ) ) -RRB- cord-005687-gj6q0ft0 15 27 , , , cord-005687-gj6q0ft0 15 28 cephalosporins cephalosporin NNS cord-005687-gj6q0ft0 15 29 ( ( -LRB- cord-005687-gj6q0ft0 15 30 beta beta NN cord-005687-gj6q0ft0 15 31 - - HYPH cord-005687-gj6q0ft0 15 32 lactamases lactamase NNS cord-005687-gj6q0ft0 15 33 ) ) -RRB- cord-005687-gj6q0ft0 15 34 and and CC cord-005687-gj6q0ft0 15 35 carbapenem carbapenem NNP cord-005687-gj6q0ft0 15 36 ( ( -LRB- cord-005687-gj6q0ft0 15 37 CPE CPE NNP cord-005687-gj6q0ft0 15 38 ) ) -RRB- cord-005687-gj6q0ft0 15 39 [ [ -LRB- cord-005687-gj6q0ft0 15 40 4 4 CD cord-005687-gj6q0ft0 15 41 ] ] -RRB- cord-005687-gj6q0ft0 15 42 . . . cord-005687-gj6q0ft0 16 1 Polymerase polymerase NN cord-005687-gj6q0ft0 16 2 chain chain NN cord-005687-gj6q0ft0 16 3 reaction reaction NN cord-005687-gj6q0ft0 16 4 ( ( -LRB- cord-005687-gj6q0ft0 16 5 PCR PCR NNP cord-005687-gj6q0ft0 16 6 ) ) -RRB- cord-005687-gj6q0ft0 16 7 is be VBZ cord-005687-gj6q0ft0 16 8 well well RB cord-005687-gj6q0ft0 16 9 established establish VBN cord-005687-gj6q0ft0 16 10 for for IN cord-005687-gj6q0ft0 16 11 the the DT cord-005687-gj6q0ft0 16 12 diagnosis diagnosis NN cord-005687-gj6q0ft0 16 13 of of IN cord-005687-gj6q0ft0 16 14 " " `` cord-005687-gj6q0ft0 16 15 atypical atypical JJ cord-005687-gj6q0ft0 16 16 " " '' cord-005687-gj6q0ft0 16 17 pathogens pathogen NNS cord-005687-gj6q0ft0 16 18 in in IN cord-005687-gj6q0ft0 16 19 severe severe JJ cord-005687-gj6q0ft0 16 20 community community NN cord-005687-gj6q0ft0 16 21 - - HYPH cord-005687-gj6q0ft0 16 22 acquired acquire VBN cord-005687-gj6q0ft0 16 23 pneumonia pneumonia NN cord-005687-gj6q0ft0 16 24 [ [ -LRB- cord-005687-gj6q0ft0 16 25 6 6 CD cord-005687-gj6q0ft0 16 26 ] ] -RRB- cord-005687-gj6q0ft0 16 27 and and CC cord-005687-gj6q0ft0 16 28 for for IN cord-005687-gj6q0ft0 16 29 the the DT cord-005687-gj6q0ft0 16 30 study study NN cord-005687-gj6q0ft0 16 31 of of IN cord-005687-gj6q0ft0 16 32 ARDS ARDS NNP cord-005687-gj6q0ft0 16 33 with with IN cord-005687-gj6q0ft0 16 34 possible possible JJ cord-005687-gj6q0ft0 16 35 infectious infectious JJ cord-005687-gj6q0ft0 16 36 etiology etiology NN cord-005687-gj6q0ft0 16 37 , , , cord-005687-gj6q0ft0 16 38 namely namely RB cord-005687-gj6q0ft0 16 39 for for IN cord-005687-gj6q0ft0 16 40 respiratory respiratory JJ cord-005687-gj6q0ft0 16 41 viruses virus NNS cord-005687-gj6q0ft0 16 42 ( ( -LRB- cord-005687-gj6q0ft0 16 43 HSV HSV NNP cord-005687-gj6q0ft0 16 44 and and CC cord-005687-gj6q0ft0 16 45 CMV CMV NNP cord-005687-gj6q0ft0 16 46 ) ) -RRB- cord-005687-gj6q0ft0 16 47 , , , cord-005687-gj6q0ft0 16 48 with with IN cord-005687-gj6q0ft0 16 49 virus virus NN cord-005687-gj6q0ft0 16 50 load load NN cord-005687-gj6q0ft0 16 51 quantification quantification NN cord-005687-gj6q0ft0 16 52 , , , cord-005687-gj6q0ft0 16 53 and and CC cord-005687-gj6q0ft0 16 54 also also RB cord-005687-gj6q0ft0 16 55 for for IN cord-005687-gj6q0ft0 16 56 Pneumocystis Pneumocystis NNP cord-005687-gj6q0ft0 16 57 and and CC cord-005687-gj6q0ft0 16 58 Aspergillus Aspergillus NNP cord-005687-gj6q0ft0 16 59 [ [ -LRB- cord-005687-gj6q0ft0 16 60 5 5 CD cord-005687-gj6q0ft0 16 61 ] ] -RRB- cord-005687-gj6q0ft0 16 62 . . . cord-005687-gj6q0ft0 17 1 In in IN cord-005687-gj6q0ft0 17 2 a a DT cord-005687-gj6q0ft0 17 3 retrospective retrospective JJ cord-005687-gj6q0ft0 17 4 case case NN cord-005687-gj6q0ft0 17 5 - - HYPH cord-005687-gj6q0ft0 17 6 control control NN cord-005687-gj6q0ft0 17 7 study study NN cord-005687-gj6q0ft0 17 8 in in IN cord-005687-gj6q0ft0 17 9 adult adult NN cord-005687-gj6q0ft0 17 10 ICU ICU NNP cord-005687-gj6q0ft0 17 11 patients patient NNS cord-005687-gj6q0ft0 17 12 with with IN cord-005687-gj6q0ft0 17 13 pneumonia pneumonia NN cord-005687-gj6q0ft0 17 14 and and CC cord-005687-gj6q0ft0 17 15 severe severe JJ cord-005687-gj6q0ft0 17 16 sepsis sepsis NN cord-005687-gj6q0ft0 17 17 or or CC cord-005687-gj6q0ft0 17 18 septic septic JJ cord-005687-gj6q0ft0 17 19 shock shock NN cord-005687-gj6q0ft0 17 20 , , , cord-005687-gj6q0ft0 17 21 a a DT cord-005687-gj6q0ft0 17 22 strategy strategy NN cord-005687-gj6q0ft0 17 23 with with IN cord-005687-gj6q0ft0 17 24 bronchoalveolar bronchoalveolar NNP cord-005687-gj6q0ft0 17 25 lavage lavage NNP cord-005687-gj6q0ft0 17 26 ( ( -LRB- cord-005687-gj6q0ft0 17 27 BAL BAL NNP cord-005687-gj6q0ft0 17 28 ) ) -RRB- cord-005687-gj6q0ft0 17 29 cultures culture NNS cord-005687-gj6q0ft0 17 30 plus plus CC cord-005687-gj6q0ft0 17 31 BAL BAL NNP cord-005687-gj6q0ft0 17 32 M M NNP cord-005687-gj6q0ft0 17 33 - - HYPH cord-005687-gj6q0ft0 17 34 PCR PCR NNP cord-005687-gj6q0ft0 17 35 led lead VBD cord-005687-gj6q0ft0 17 36 to to IN cord-005687-gj6q0ft0 17 37 higher high JJR cord-005687-gj6q0ft0 17 38 microbiological microbiological JJ cord-005687-gj6q0ft0 17 39 yield yield NN cord-005687-gj6q0ft0 17 40 and and CC cord-005687-gj6q0ft0 17 41 less less JJR cord-005687-gj6q0ft0 17 42 time time NN cord-005687-gj6q0ft0 17 43 to to IN cord-005687-gj6q0ft0 17 44 antibiotic antibiotic JJ cord-005687-gj6q0ft0 17 45 therapy therapy NN cord-005687-gj6q0ft0 17 46 modification modification NN cord-005687-gj6q0ft0 17 47 compared compare VBN cord-005687-gj6q0ft0 17 48 to to IN cord-005687-gj6q0ft0 17 49 a a DT cord-005687-gj6q0ft0 17 50 BAL bal NN cord-005687-gj6q0ft0 17 51 culture culture NN cord-005687-gj6q0ft0 17 52 strategy strategy NN cord-005687-gj6q0ft0 17 53 ( ( -LRB- cord-005687-gj6q0ft0 17 54 32.40 32.40 CD cord-005687-gj6q0ft0 17 55 ± ± CD cord-005687-gj6q0ft0 17 56 14.41 14.41 CD cord-005687-gj6q0ft0 17 57 vs. vs. IN cord-005687-gj6q0ft0 17 58 41.74 41.74 CD cord-005687-gj6q0ft0 17 59 ± ± NNP cord-005687-gj6q0ft0 17 60 45.61 45.61 CD cord-005687-gj6q0ft0 17 61 h h NN cord-005687-gj6q0ft0 17 62 ; ; : cord-005687-gj6q0ft0 17 63 P p NN cord-005687-gj6q0ft0 17 64 < < XX cord-005687-gj6q0ft0 17 65 .001 .001 CD cord-005687-gj6q0ft0 17 66 ) ) -RRB- cord-005687-gj6q0ft0 18 1 [ [ -LRB- cord-005687-gj6q0ft0 18 2 7 7 CD cord-005687-gj6q0ft0 18 3 ] ] -RRB- cord-005687-gj6q0ft0 18 4 . . . cord-005687-gj6q0ft0 19 1 However however RB cord-005687-gj6q0ft0 19 2 , , , cord-005687-gj6q0ft0 19 3 several several JJ cord-005687-gj6q0ft0 19 4 criticisms criticism NNS cord-005687-gj6q0ft0 19 5 have have VBP cord-005687-gj6q0ft0 19 6 been be VBN cord-005687-gj6q0ft0 19 7 raised raise VBN cord-005687-gj6q0ft0 19 8 with with IN cord-005687-gj6q0ft0 19 9 the the DT cord-005687-gj6q0ft0 19 10 use use NN cord-005687-gj6q0ft0 19 11 of of IN cord-005687-gj6q0ft0 19 12 real real JJ cord-005687-gj6q0ft0 19 13 - - HYPH cord-005687-gj6q0ft0 19 14 time time NN cord-005687-gj6q0ft0 19 15 PCR PCR NNP cord-005687-gj6q0ft0 19 16 for for IN cord-005687-gj6q0ft0 19 17 the the DT cord-005687-gj6q0ft0 19 18 study study NN cord-005687-gj6q0ft0 19 19 of of IN cord-005687-gj6q0ft0 19 20 suspected suspect VBN cord-005687-gj6q0ft0 19 21 sepsis sepsis NN cord-005687-gj6q0ft0 19 22 and and CC cord-005687-gj6q0ft0 19 23 BSI BSI NNP cord-005687-gj6q0ft0 19 24 . . . cord-005687-gj6q0ft0 20 1 A a DT cord-005687-gj6q0ft0 20 2 study study NN cord-005687-gj6q0ft0 20 3 showed show VBD cord-005687-gj6q0ft0 20 4 that that IN cord-005687-gj6q0ft0 20 5 the the DT cord-005687-gj6q0ft0 20 6 post post JJ cord-005687-gj6q0ft0 20 7 - - JJ cord-005687-gj6q0ft0 20 8 test test JJ cord-005687-gj6q0ft0 20 9 probability probability NN cord-005687-gj6q0ft0 20 10 of of IN cord-005687-gj6q0ft0 20 11 both both CC cord-005687-gj6q0ft0 20 12 a a DT cord-005687-gj6q0ft0 20 13 positive positive JJ cord-005687-gj6q0ft0 20 14 ( ( -LRB- cord-005687-gj6q0ft0 20 15 26.3 26.3 CD cord-005687-gj6q0ft0 20 16 , , , cord-005687-gj6q0ft0 20 17 95 95 CD cord-005687-gj6q0ft0 20 18 % % NN cord-005687-gj6q0ft0 20 19 CI CI NNP cord-005687-gj6q0ft0 20 20 19.8 19.8 CD cord-005687-gj6q0ft0 20 21 - - HYPH cord-005687-gj6q0ft0 20 22 33.7 33.7 CD cord-005687-gj6q0ft0 20 23 % % NN cord-005687-gj6q0ft0 20 24 ) ) -RRB- cord-005687-gj6q0ft0 20 25 and and CC cord-005687-gj6q0ft0 20 26 a a DT cord-005687-gj6q0ft0 20 27 negative negative JJ cord-005687-gj6q0ft0 20 28 ( ( -LRB- cord-005687-gj6q0ft0 20 29 5.6 5.6 CD cord-005687-gj6q0ft0 20 30 , , , cord-005687-gj6q0ft0 20 31 95 95 CD cord-005687-gj6q0ft0 20 32 % % NN cord-005687-gj6q0ft0 20 33 CI CI NNP cord-005687-gj6q0ft0 20 34 4.1 4.1 CD cord-005687-gj6q0ft0 20 35 - - SYM cord-005687-gj6q0ft0 20 36 7.4 7.4 CD cord-005687-gj6q0ft0 20 37 % % NN cord-005687-gj6q0ft0 20 38 ) ) -RRB- cord-005687-gj6q0ft0 21 1 SeptiFast SeptiFast NNP cord-005687-gj6q0ft0 21 2 test test NN cord-005687-gj6q0ft0 21 3 indicated indicate VBD cord-005687-gj6q0ft0 21 4 potential potential JJ cord-005687-gj6q0ft0 21 5 limitations limitation NNS cord-005687-gj6q0ft0 21 6 of of IN cord-005687-gj6q0ft0 21 7 the the DT cord-005687-gj6q0ft0 21 8 technique technique NN cord-005687-gj6q0ft0 21 9 in in IN cord-005687-gj6q0ft0 21 10 diagnosing diagnose VBG cord-005687-gj6q0ft0 21 11 BSI BSI NNP cord-005687-gj6q0ft0 21 12 in in IN cord-005687-gj6q0ft0 21 13 patients patient NNS cord-005687-gj6q0ft0 21 14 that that WDT cord-005687-gj6q0ft0 21 15 had have VBD cord-005687-gj6q0ft0 21 16 been be VBN cord-005687-gj6q0ft0 21 17 admitted admit VBN cord-005687-gj6q0ft0 21 18 for for IN cord-005687-gj6q0ft0 21 19 an an DT cord-005687-gj6q0ft0 21 20 average average NN cord-005687-gj6q0ft0 21 21 of of IN cord-005687-gj6q0ft0 21 22 8 8 CD cord-005687-gj6q0ft0 21 23 days day NNS cord-005687-gj6q0ft0 21 24 in in IN cord-005687-gj6q0ft0 21 25 hospital hospital NN cord-005687-gj6q0ft0 21 26 and and CC cord-005687-gj6q0ft0 21 27 had have VBD cord-005687-gj6q0ft0 21 28 recently recently RB cord-005687-gj6q0ft0 21 29 received receive VBN cord-005687-gj6q0ft0 21 30 antibiotics antibiotic NNS cord-005687-gj6q0ft0 21 31 and and CC cord-005687-gj6q0ft0 21 32 organ organ NN cord-005687-gj6q0ft0 21 33 support support NN cord-005687-gj6q0ft0 21 34 [ [ -LRB- cord-005687-gj6q0ft0 21 35 8 8 CD cord-005687-gj6q0ft0 21 36 ] ] -RRB- cord-005687-gj6q0ft0 21 37 . . . cord-005687-gj6q0ft0 22 1 A a DT cord-005687-gj6q0ft0 22 2 systematic systematic JJ cord-005687-gj6q0ft0 22 3 review review NN cord-005687-gj6q0ft0 22 4 and and CC cord-005687-gj6q0ft0 22 5 meta meta NNP cord-005687-gj6q0ft0 22 6 - - HYPH cord-005687-gj6q0ft0 22 7 analysis analysis NN cord-005687-gj6q0ft0 22 8 showed show VBD cord-005687-gj6q0ft0 22 9 that that IN cord-005687-gj6q0ft0 22 10 , , , cord-005687-gj6q0ft0 22 11 in in IN cord-005687-gj6q0ft0 22 12 suspected suspect VBN cord-005687-gj6q0ft0 22 13 sepsis sepsis NN cord-005687-gj6q0ft0 22 14 , , , cord-005687-gj6q0ft0 22 15 SeptiFast SeptiFast NNP cord-005687-gj6q0ft0 22 16 has have VBZ cord-005687-gj6q0ft0 22 17 higher high JJR cord-005687-gj6q0ft0 22 18 specificity specificity NN cord-005687-gj6q0ft0 22 19 than than IN cord-005687-gj6q0ft0 22 20 sensitivity sensitivity NN cord-005687-gj6q0ft0 22 21 , , , cord-005687-gj6q0ft0 22 22 being be VBG cord-005687-gj6q0ft0 22 23 better well JJR cord-005687-gj6q0ft0 22 24 for for IN cord-005687-gj6q0ft0 22 25 ruling rule VBG cord-005687-gj6q0ft0 22 26 in in IN cord-005687-gj6q0ft0 22 27 than than IN cord-005687-gj6q0ft0 22 28 for for IN cord-005687-gj6q0ft0 22 29 ruling rule VBG cord-005687-gj6q0ft0 22 30 out out RP cord-005687-gj6q0ft0 22 31 infection infection NN cord-005687-gj6q0ft0 22 32 [ [ -LRB- cord-005687-gj6q0ft0 22 33 9 9 CD cord-005687-gj6q0ft0 22 34 ] ] -RRB- cord-005687-gj6q0ft0 22 35 . . . cord-005687-gj6q0ft0 23 1 There there EX cord-005687-gj6q0ft0 23 2 are be VBP cord-005687-gj6q0ft0 23 3 a a DT cord-005687-gj6q0ft0 23 4 number number NN cord-005687-gj6q0ft0 23 5 of of IN cord-005687-gj6q0ft0 23 6 important important JJ cord-005687-gj6q0ft0 23 7 considerations consideration NNS cord-005687-gj6q0ft0 23 8 when when WRB cord-005687-gj6q0ft0 23 9 critiquing critique VBG cord-005687-gj6q0ft0 23 10 studies study NNS cord-005687-gj6q0ft0 23 11 comparing compare VBG cord-005687-gj6q0ft0 23 12 blood blood NN cord-005687-gj6q0ft0 23 13 cultures culture NNS cord-005687-gj6q0ft0 23 14 with with IN cord-005687-gj6q0ft0 23 15 nucleic nucleic JJ cord-005687-gj6q0ft0 23 16 acid acid NN cord-005687-gj6q0ft0 23 17 diagnostic diagnostic JJ cord-005687-gj6q0ft0 23 18 techniques technique NNS cord-005687-gj6q0ft0 23 19 . . . cord-005687-gj6q0ft0 24 1 False false JJ cord-005687-gj6q0ft0 24 2 negative negative JJ cord-005687-gj6q0ft0 24 3 PCR pcr NN cord-005687-gj6q0ft0 24 4 tests test NNS cord-005687-gj6q0ft0 24 5 can can MD cord-005687-gj6q0ft0 24 6 occur occur VB cord-005687-gj6q0ft0 24 7 by by IN cord-005687-gj6q0ft0 24 8 interference interference NN cord-005687-gj6q0ft0 24 9 with with IN cord-005687-gj6q0ft0 24 10 human human JJ cord-005687-gj6q0ft0 24 11 DNA dna NN cord-005687-gj6q0ft0 24 12 and and CC cord-005687-gj6q0ft0 24 13 the the DT cord-005687-gj6q0ft0 24 14 presence presence NN cord-005687-gj6q0ft0 24 15 of of IN cord-005687-gj6q0ft0 24 16 PCR PCR NNP cord-005687-gj6q0ft0 24 17 inhibitors inhibitor NNS cord-005687-gj6q0ft0 24 18 in in IN cord-005687-gj6q0ft0 24 19 the the DT cord-005687-gj6q0ft0 24 20 blood blood NN cord-005687-gj6q0ft0 24 21 . . . cord-005687-gj6q0ft0 25 1 Furthermore furthermore RB cord-005687-gj6q0ft0 25 2 , , , cord-005687-gj6q0ft0 25 3 they -PRON- PRP cord-005687-gj6q0ft0 25 4 can can MD cord-005687-gj6q0ft0 25 5 only only RB cord-005687-gj6q0ft0 25 6 detect detect VB cord-005687-gj6q0ft0 25 7 pathogens pathogen NNS cord-005687-gj6q0ft0 25 8 that that WDT cord-005687-gj6q0ft0 25 9 are be VBP cord-005687-gj6q0ft0 25 10 specifically specifically RB cord-005687-gj6q0ft0 25 11 tested test VBN cord-005687-gj6q0ft0 25 12 for for IN cord-005687-gj6q0ft0 25 13 . . . cord-005687-gj6q0ft0 26 1 On on IN cord-005687-gj6q0ft0 26 2 the the DT cord-005687-gj6q0ft0 26 3 other other JJ cord-005687-gj6q0ft0 26 4 hand hand NN cord-005687-gj6q0ft0 26 5 , , , cord-005687-gj6q0ft0 26 6 blood blood NN cord-005687-gj6q0ft0 26 7 cultures culture NNS cord-005687-gj6q0ft0 26 8 are be VBP cord-005687-gj6q0ft0 26 9 less less RBR cord-005687-gj6q0ft0 26 10 sensitive sensitive JJ cord-005687-gj6q0ft0 26 11 especially especially RB cord-005687-gj6q0ft0 26 12 in in IN cord-005687-gj6q0ft0 26 13 the the DT cord-005687-gj6q0ft0 26 14 setting setting NN cord-005687-gj6q0ft0 26 15 of of IN cord-005687-gj6q0ft0 26 16 recent recent JJ cord-005687-gj6q0ft0 26 17 exposure exposure NN cord-005687-gj6q0ft0 26 18 to to IN cord-005687-gj6q0ft0 26 19 antibiotics antibiotic NNS cord-005687-gj6q0ft0 26 20 . . . cord-005687-gj6q0ft0 27 1 Overall overall RB cord-005687-gj6q0ft0 27 2 , , , cord-005687-gj6q0ft0 27 3 blood blood NN cord-005687-gj6q0ft0 27 4 cultures culture NNS cord-005687-gj6q0ft0 27 5 have have VBP cord-005687-gj6q0ft0 27 6 only only RB cord-005687-gj6q0ft0 27 7 70 70 CD cord-005687-gj6q0ft0 27 8 % % NN cord-005687-gj6q0ft0 27 9 specificity specificity NN cord-005687-gj6q0ft0 27 10 , , , cord-005687-gj6q0ft0 27 11 and and CC cord-005687-gj6q0ft0 27 12 sensitivity sensitivity NN cord-005687-gj6q0ft0 28 1 * * NFP cord-005687-gj6q0ft0 28 2 Correspondence correspondence NN cord-005687-gj6q0ft0 28 3 : : : cord-005687-gj6q0ft0 29 1 jarturpaiva@gmail.com jarturpaiva@gmail.com NNP cord-005687-gj6q0ft0 29 2 is be VBZ cord-005687-gj6q0ft0 29 3 approximately approximately RB cord-005687-gj6q0ft0 29 4 10 10 CD cord-005687-gj6q0ft0 29 5 % % NN cord-005687-gj6q0ft0 29 6 in in IN cord-005687-gj6q0ft0 29 7 suspected suspect VBN cord-005687-gj6q0ft0 29 8 bacteremia bacteremia NN cord-005687-gj6q0ft0 29 9 , , , cord-005687-gj6q0ft0 29 10 30 30 CD cord-005687-gj6q0ft0 29 11 % % NN cord-005687-gj6q0ft0 29 12 in in IN cord-005687-gj6q0ft0 29 13 febrile febrile JJ cord-005687-gj6q0ft0 29 14 neutropenia neutropenia NN cord-005687-gj6q0ft0 29 15 , , , cord-005687-gj6q0ft0 29 16 35 35 CD cord-005687-gj6q0ft0 29 17 % % NN cord-005687-gj6q0ft0 29 18 in in IN cord-005687-gj6q0ft0 29 19 severe severe JJ cord-005687-gj6q0ft0 29 20 sepsis sepsis NN cord-005687-gj6q0ft0 29 21 , , , cord-005687-gj6q0ft0 29 22 and and CC cord-005687-gj6q0ft0 29 23 50 50 CD cord-005687-gj6q0ft0 29 24 % % NN cord-005687-gj6q0ft0 29 25 in in IN cord-005687-gj6q0ft0 29 26 septic septic JJ cord-005687-gj6q0ft0 29 27 shock shock NN cord-005687-gj6q0ft0 29 28 [ [ -LRB- cord-005687-gj6q0ft0 29 29 10 10 CD cord-005687-gj6q0ft0 29 30 ] ] -RRB- cord-005687-gj6q0ft0 29 31 . . . cord-005687-gj6q0ft0 30 1 Defining define VBG cord-005687-gj6q0ft0 30 2 a a DT cord-005687-gj6q0ft0 30 3 true true JJ cord-005687-gj6q0ft0 30 4 positive positive JJ cord-005687-gj6q0ft0 30 5 result result NN cord-005687-gj6q0ft0 30 6 for for IN cord-005687-gj6q0ft0 30 7 evaluating evaluate VBG cord-005687-gj6q0ft0 30 8 diagnostic diagnostic JJ cord-005687-gj6q0ft0 30 9 tests test NNS cord-005687-gj6q0ft0 30 10 for for IN cord-005687-gj6q0ft0 30 11 infection infection NN cord-005687-gj6q0ft0 30 12 is be VBZ cord-005687-gj6q0ft0 30 13 challenging challenging JJ cord-005687-gj6q0ft0 30 14 and and CC cord-005687-gj6q0ft0 30 15 may may MD cord-005687-gj6q0ft0 30 16 be be VB cord-005687-gj6q0ft0 30 17 best good JJS cord-005687-gj6q0ft0 30 18 by by IN cord-005687-gj6q0ft0 30 19 a a DT cord-005687-gj6q0ft0 30 20 composite composite JJ cord-005687-gj6q0ft0 30 21 measure measure NN cord-005687-gj6q0ft0 30 22 that that WDT cord-005687-gj6q0ft0 30 23 includes include VBZ cord-005687-gj6q0ft0 30 24 clinical clinical JJ cord-005687-gj6q0ft0 30 25 status status NN cord-005687-gj6q0ft0 30 26 and and CC cord-005687-gj6q0ft0 30 27 type type NN cord-005687-gj6q0ft0 30 28 and and CC cord-005687-gj6q0ft0 30 29 severity severity NN cord-005687-gj6q0ft0 30 30 of of IN cord-005687-gj6q0ft0 30 31 infection infection NN cord-005687-gj6q0ft0 30 32 . . . cord-005687-gj6q0ft0 31 1 Recently recently RB cord-005687-gj6q0ft0 31 2 , , , cord-005687-gj6q0ft0 31 3 a a DT cord-005687-gj6q0ft0 31 4 comprehensive comprehensive JJ cord-005687-gj6q0ft0 31 5 literature literature NN cord-005687-gj6q0ft0 31 6 search search NN cord-005687-gj6q0ft0 31 7 was be VBD cord-005687-gj6q0ft0 31 8 conducted conduct VBN cord-005687-gj6q0ft0 31 9 to to TO cord-005687-gj6q0ft0 31 10 identify identify VB cord-005687-gj6q0ft0 31 11 studies study NNS cord-005687-gj6q0ft0 31 12 with with IN cord-005687-gj6q0ft0 31 13 measurable measurable JJ cord-005687-gj6q0ft0 31 14 outcomes outcome NNS cord-005687-gj6q0ft0 31 15 to to TO cord-005687-gj6q0ft0 31 16 evaluate evaluate VB cord-005687-gj6q0ft0 31 17 the the DT cord-005687-gj6q0ft0 31 18 evidence evidence NN cord-005687-gj6q0ft0 31 19 for for IN cord-005687-gj6q0ft0 31 20 the the DT cord-005687-gj6q0ft0 31 21 effectiveness effectiveness NN cord-005687-gj6q0ft0 31 22 of of IN cord-005687-gj6q0ft0 31 23 different different JJ cord-005687-gj6q0ft0 31 24 rapid rapid JJ cord-005687-gj6q0ft0 31 25 diagnostic diagnostic JJ cord-005687-gj6q0ft0 31 26 practices practice NNS cord-005687-gj6q0ft0 31 27 in in IN cord-005687-gj6q0ft0 31 28 decreasing decrease VBG cord-005687-gj6q0ft0 31 29 time time NN cord-005687-gj6q0ft0 31 30 to to IN cord-005687-gj6q0ft0 31 31 targeted target VBN cord-005687-gj6q0ft0 31 32 therapy therapy NN cord-005687-gj6q0ft0 31 33 for for IN cord-005687-gj6q0ft0 31 34 hospitalized hospitalize VBN cord-005687-gj6q0ft0 31 35 patients patient NNS cord-005687-gj6q0ft0 31 36 with with IN cord-005687-gj6q0ft0 31 37 BSI BSI NNP cord-005687-gj6q0ft0 31 38 [ [ -LRB- cord-005687-gj6q0ft0 31 39 1 1 CD cord-005687-gj6q0ft0 31 40 ] ] -RRB- cord-005687-gj6q0ft0 31 41 . . . cord-005687-gj6q0ft0 32 1 The the DT cord-005687-gj6q0ft0 32 2 authors author NNS cord-005687-gj6q0ft0 32 3 concluded conclude VBD cord-005687-gj6q0ft0 32 4 that that IN cord-005687-gj6q0ft0 32 5 rapid rapid JJ cord-005687-gj6q0ft0 32 6 phenotypic phenotypic JJ cord-005687-gj6q0ft0 32 7 techniques technique NNS cord-005687-gj6q0ft0 32 8 with with IN cord-005687-gj6q0ft0 32 9 direct direct JJ cord-005687-gj6q0ft0 32 10 communication communication NN cord-005687-gj6q0ft0 32 11 likely likely RB cord-005687-gj6q0ft0 32 12 improve improve VB cord-005687-gj6q0ft0 32 13 the the DT cord-005687-gj6q0ft0 32 14 timeliness timeliness NN cord-005687-gj6q0ft0 32 15 of of IN cord-005687-gj6q0ft0 32 16 targeted target VBN cord-005687-gj6q0ft0 32 17 therapy therapy NN cord-005687-gj6q0ft0 32 18 and and CC cord-005687-gj6q0ft0 32 19 that that IN cord-005687-gj6q0ft0 32 20 rapid rapid JJ cord-005687-gj6q0ft0 32 21 molecular molecular JJ cord-005687-gj6q0ft0 32 22 testing testing NN cord-005687-gj6q0ft0 32 23 with with IN cord-005687-gj6q0ft0 32 24 direct direct JJ cord-005687-gj6q0ft0 32 25 communication communication NN cord-005687-gj6q0ft0 32 26 significantly significantly RB cord-005687-gj6q0ft0 32 27 improves improve VBZ cord-005687-gj6q0ft0 32 28 timeliness timeliness NN cord-005687-gj6q0ft0 32 29 and and CC cord-005687-gj6q0ft0 32 30 significantly significantly RB cord-005687-gj6q0ft0 32 31 reduces reduce VBZ cord-005687-gj6q0ft0 32 32 mortality mortality NN cord-005687-gj6q0ft0 32 33 , , , cord-005687-gj6q0ft0 32 34 compared compare VBN cord-005687-gj6q0ft0 32 35 to to IN cord-005687-gj6q0ft0 32 36 standard standard JJ cord-005687-gj6q0ft0 32 37 testing testing NN cord-005687-gj6q0ft0 32 38 . . . cord-005687-gj6q0ft0 33 1 Since since IN cord-005687-gj6q0ft0 33 2 publication publication NN cord-005687-gj6q0ft0 33 3 of of IN cord-005687-gj6q0ft0 33 4 this this DT cord-005687-gj6q0ft0 33 5 review review NN cord-005687-gj6q0ft0 33 6 , , , cord-005687-gj6q0ft0 33 7 the the DT cord-005687-gj6q0ft0 33 8 RADI RADI NNP cord-005687-gj6q0ft0 33 9 - - HYPH cord-005687-gj6q0ft0 33 10 CAL CAL NNP cord-005687-gj6q0ft0 33 11 study study NN cord-005687-gj6q0ft0 33 12 [ [ -LRB- cord-005687-gj6q0ft0 33 13 11 11 CD cord-005687-gj6q0ft0 33 14 ] ] -RRB- cord-005687-gj6q0ft0 33 15 , , , cord-005687-gj6q0ft0 33 16 an an DT cord-005687-gj6q0ft0 33 17 observational observational JJ cord-005687-gj6q0ft0 33 18 study study NN cord-005687-gj6q0ft0 33 19 with with IN cord-005687-gj6q0ft0 33 20 patients patient NNS cord-005687-gj6q0ft0 33 21 with with IN cord-005687-gj6q0ft0 33 22 suspected suspect VBN cord-005687-gj6q0ft0 33 23 or or CC cord-005687-gj6q0ft0 33 24 proven prove VBN cord-005687-gj6q0ft0 33 25 BSI BSI NNP cord-005687-gj6q0ft0 33 26 , , , cord-005687-gj6q0ft0 33 27 pneumonia pneumonia NN cord-005687-gj6q0ft0 33 28 , , , cord-005687-gj6q0ft0 33 29 or or CC cord-005687-gj6q0ft0 33 30 sterile sterile JJ cord-005687-gj6q0ft0 33 31 fluid fluid NN cord-005687-gj6q0ft0 33 32 and and CC cord-005687-gj6q0ft0 33 33 tissue tissue NN cord-005687-gj6q0ft0 33 34 infection infection NN cord-005687-gj6q0ft0 33 35 in in IN cord-005687-gj6q0ft0 33 36 nine nine CD cord-005687-gj6q0ft0 33 37 ICUs icu NNS cord-005687-gj6q0ft0 33 38 , , , cord-005687-gj6q0ft0 33 39 showed show VBD cord-005687-gj6q0ft0 33 40 that that IN cord-005687-gj6q0ft0 33 41 PCR PCR NNP cord-005687-gj6q0ft0 33 42 / / SYM cord-005687-gj6q0ft0 33 43 electrospray electrospray JJ cord-005687-gj6q0ft0 33 44 ionization ionization NN cord-005687-gj6q0ft0 33 45 - - HYPH cord-005687-gj6q0ft0 33 46 mass mass NN cord-005687-gj6q0ft0 33 47 spectrometry spectrometry NN cord-005687-gj6q0ft0 33 48 provides provide VBZ cord-005687-gj6q0ft0 33 49 rapid rapid JJ cord-005687-gj6q0ft0 33 50 pathogen pathogen NN cord-005687-gj6q0ft0 33 51 identification identification NN cord-005687-gj6q0ft0 33 52 with with IN cord-005687-gj6q0ft0 33 53 a a DT cord-005687-gj6q0ft0 33 54 sensitivity sensitivity NN cord-005687-gj6q0ft0 33 55 of of IN cord-005687-gj6q0ft0 33 56 81 81 CD cord-005687-gj6q0ft0 33 57 % % NN cord-005687-gj6q0ft0 33 58 , , , cord-005687-gj6q0ft0 33 59 specificity specificity NN cord-005687-gj6q0ft0 33 60 of of IN cord-005687-gj6q0ft0 33 61 69 69 CD cord-005687-gj6q0ft0 33 62 % % NN cord-005687-gj6q0ft0 33 63 , , , cord-005687-gj6q0ft0 33 64 and and CC cord-005687-gj6q0ft0 33 65 negative negative JJ cord-005687-gj6q0ft0 33 66 predictive predictive JJ cord-005687-gj6q0ft0 33 67 value value NN cord-005687-gj6q0ft0 33 68 of of IN cord-005687-gj6q0ft0 33 69 97 97 CD cord-005687-gj6q0ft0 33 70 % % NN cord-005687-gj6q0ft0 33 71 at at IN cord-005687-gj6q0ft0 33 72 6 6 CD cord-005687-gj6q0ft0 33 73 h h NN cord-005687-gj6q0ft0 33 74 from from IN cord-005687-gj6q0ft0 33 75 sample sample NN cord-005687-gj6q0ft0 33 76 acquisition acquisition NN cord-005687-gj6q0ft0 33 77 and and CC cord-005687-gj6q0ft0 33 78 that that DT cord-005687-gj6q0ft0 33 79 treatment treatment NN cord-005687-gj6q0ft0 33 80 could could MD cord-005687-gj6q0ft0 33 81 have have VB cord-005687-gj6q0ft0 33 82 been be VBN cord-005687-gj6q0ft0 33 83 altered alter VBN cord-005687-gj6q0ft0 33 84 in in IN cord-005687-gj6q0ft0 33 85 up up IN cord-005687-gj6q0ft0 33 86 to to TO cord-005687-gj6q0ft0 33 87 57 57 CD cord-005687-gj6q0ft0 33 88 % % NN cord-005687-gj6q0ft0 33 89 of of IN cord-005687-gj6q0ft0 33 90 patients patient NNS cord-005687-gj6q0ft0 33 91 . . . cord-005687-gj6q0ft0 34 1 Further further RB cord-005687-gj6q0ft0 34 2 , , , cord-005687-gj6q0ft0 34 3 Banerjee Banerjee NNP cord-005687-gj6q0ft0 34 4 et et NNP cord-005687-gj6q0ft0 34 5 al al NNP cord-005687-gj6q0ft0 34 6 . . NNP cord-005687-gj6q0ft0 34 7 , , , cord-005687-gj6q0ft0 34 8 in in IN cord-005687-gj6q0ft0 34 9 a a DT cord-005687-gj6q0ft0 34 10 prospective prospective JJ cord-005687-gj6q0ft0 34 11 randomized randomize VBN cord-005687-gj6q0ft0 34 12 controlled control VBN cord-005687-gj6q0ft0 34 13 trial trial NN cord-005687-gj6q0ft0 34 14 , , , cord-005687-gj6q0ft0 34 15 studied study VBD cord-005687-gj6q0ft0 34 16 617 617 CD cord-005687-gj6q0ft0 34 17 patients patient NNS cord-005687-gj6q0ft0 34 18 with with IN cord-005687-gj6q0ft0 34 19 positive positive JJ cord-005687-gj6q0ft0 34 20 blood blood NN cord-005687-gj6q0ft0 34 21 cultures culture NNS cord-005687-gj6q0ft0 34 22 and and CC cord-005687-gj6q0ft0 34 23 stratified stratified JJ cord-005687-gj6q0ft0 34 24 randomization randomization NN cord-005687-gj6q0ft0 34 25 into into IN cord-005687-gj6q0ft0 34 26 3 3 CD cord-005687-gj6q0ft0 34 27 arms arm NNS cord-005687-gj6q0ft0 34 28 : : : cord-005687-gj6q0ft0 34 29 standard standard JJ cord-005687-gj6q0ft0 34 30 blood blood NN cord-005687-gj6q0ft0 34 31 culture culture NN cord-005687-gj6q0ft0 34 32 processing processing NN cord-005687-gj6q0ft0 34 33 ( ( -LRB- cord-005687-gj6q0ft0 34 34 control control NN cord-005687-gj6q0ft0 34 35 ) ) -RRB- cord-005687-gj6q0ft0 34 36 , , , cord-005687-gj6q0ft0 34 37 rapid rapid JJ cord-005687-gj6q0ft0 34 38 - - HYPH cord-005687-gj6q0ft0 34 39 multiplex multiplex NN cord-005687-gj6q0ft0 34 40 PCR PCR NNP cord-005687-gj6q0ft0 34 41 ( ( -LRB- cord-005687-gj6q0ft0 34 42 rmPCR rmpcr NN cord-005687-gj6q0ft0 34 43 ) ) -RRB- cord-005687-gj6q0ft0 34 44 reported report VBN cord-005687-gj6q0ft0 34 45 with with IN cord-005687-gj6q0ft0 34 46 templated templated JJ cord-005687-gj6q0ft0 34 47 comments comment NNS cord-005687-gj6q0ft0 34 48 or or CC cord-005687-gj6q0ft0 34 49 rmPCR rmpcr NN cord-005687-gj6q0ft0 34 50 reported report VBN cord-005687-gj6q0ft0 34 51 with with IN cord-005687-gj6q0ft0 34 52 templated templated JJ cord-005687-gj6q0ft0 34 53 comments comment NNS cord-005687-gj6q0ft0 34 54 and and CC cord-005687-gj6q0ft0 34 55 real real JJ cord-005687-gj6q0ft0 34 56 - - HYPH cord-005687-gj6q0ft0 34 57 time time NN cord-005687-gj6q0ft0 34 58 audit audit NN cord-005687-gj6q0ft0 34 59 and and CC cord-005687-gj6q0ft0 34 60 feedback feedback NN cord-005687-gj6q0ft0 34 61 of of IN cord-005687-gj6q0ft0 34 62 antimicrobial antimicrobial JJ cord-005687-gj6q0ft0 34 63 orders order NNS cord-005687-gj6q0ft0 34 64 by by IN cord-005687-gj6q0ft0 34 65 an an DT cord-005687-gj6q0ft0 34 66 AST AST NNP cord-005687-gj6q0ft0 34 67 team team NN cord-005687-gj6q0ft0 34 68 [ [ -LRB- cord-005687-gj6q0ft0 34 69 12 12 CD cord-005687-gj6q0ft0 34 70 ] ] -RRB- cord-005687-gj6q0ft0 34 71 . . . cord-005687-gj6q0ft0 35 1 Antibiotic antibiotic JJ cord-005687-gj6q0ft0 35 2 de de NN cord-005687-gj6q0ft0 35 3 - - NN cord-005687-gj6q0ft0 35 4 escalation escalation NN cord-005687-gj6q0ft0 35 5 occurred occur VBD cord-005687-gj6q0ft0 35 6 19 19 CD cord-005687-gj6q0ft0 35 7 h h NN cord-005687-gj6q0ft0 35 8 faster fast RBR cord-005687-gj6q0ft0 35 9 in in IN cord-005687-gj6q0ft0 35 10 the the DT cord-005687-gj6q0ft0 35 11 rmPCR/ rmPCR/ NNP cord-005687-gj6q0ft0 35 12 AST AST NNP cord-005687-gj6q0ft0 35 13 group group NN cord-005687-gj6q0ft0 35 14 than than IN cord-005687-gj6q0ft0 35 15 in in IN cord-005687-gj6q0ft0 35 16 controls control NNS cord-005687-gj6q0ft0 35 17 , , , cord-005687-gj6q0ft0 35 18 with with IN cord-005687-gj6q0ft0 35 19 almost almost RB cord-005687-gj6q0ft0 35 20 a a DT cord-005687-gj6q0ft0 35 21 25 25 CD cord-005687-gj6q0ft0 35 22 % % NN cord-005687-gj6q0ft0 35 23 reduction reduction NN cord-005687-gj6q0ft0 35 24 in in IN cord-005687-gj6q0ft0 35 25 broad broad JJ cord-005687-gj6q0ft0 35 26 - - HYPH cord-005687-gj6q0ft0 35 27 spectrum spectrum NN cord-005687-gj6q0ft0 35 28 antibiotic antibiotic JJ cord-005687-gj6q0ft0 35 29 days day NNS cord-005687-gj6q0ft0 35 30 of of IN cord-005687-gj6q0ft0 35 31 therapy therapy NN cord-005687-gj6q0ft0 35 32 . . . cord-005687-gj6q0ft0 36 1 The the DT cord-005687-gj6q0ft0 36 2 EVAMICA EVAMICA NNP cord-005687-gj6q0ft0 36 3 study study NN cord-005687-gj6q0ft0 36 4 , , , cord-005687-gj6q0ft0 36 5 recently recently RB cord-005687-gj6q0ft0 36 6 published publish VBN cord-005687-gj6q0ft0 36 7 in in IN cord-005687-gj6q0ft0 36 8 this this DT cord-005687-gj6q0ft0 36 9 journal journal NN cord-005687-gj6q0ft0 36 10 , , , cord-005687-gj6q0ft0 36 11 is be VBZ cord-005687-gj6q0ft0 36 12 an an DT cord-005687-gj6q0ft0 36 13 important important JJ cord-005687-gj6q0ft0 36 14 addition addition NN cord-005687-gj6q0ft0 36 15 to to IN cord-005687-gj6q0ft0 36 16 the the DT cord-005687-gj6q0ft0 36 17 body body NN cord-005687-gj6q0ft0 36 18 of of IN cord-005687-gj6q0ft0 36 19 literature literature NN cord-005687-gj6q0ft0 36 20 investigating investigate VBG cord-005687-gj6q0ft0 36 21 rapid rapid JJ cord-005687-gj6q0ft0 36 22 diagnostic diagnostic JJ cord-005687-gj6q0ft0 36 23 techniques technique NNS cord-005687-gj6q0ft0 36 24 in in IN cord-005687-gj6q0ft0 36 25 the the DT cord-005687-gj6q0ft0 36 26 ICU ICU NNP cord-005687-gj6q0ft0 36 27 [ [ -LRB- cord-005687-gj6q0ft0 36 28 13 13 CD cord-005687-gj6q0ft0 36 29 ] ] -RRB- cord-005687-gj6q0ft0 36 30 . . . cord-005687-gj6q0ft0 37 1 This this DT cord-005687-gj6q0ft0 37 2 multicentre multicentre NNP cord-005687-gj6q0ft0 37 3 cluster cluster NN cord-005687-gj6q0ft0 37 4 - - HYPH cord-005687-gj6q0ft0 37 5 randomised randomised JJ cord-005687-gj6q0ft0 37 6 crossover crossover NN cord-005687-gj6q0ft0 37 7 trial trial NN cord-005687-gj6q0ft0 37 8 included include VBD cord-005687-gj6q0ft0 37 9 1416 1416 CD cord-005687-gj6q0ft0 37 10 patients patient NNS cord-005687-gj6q0ft0 37 11 and and CC cord-005687-gj6q0ft0 37 12 confirms confirm VBZ cord-005687-gj6q0ft0 37 13 that that IN cord-005687-gj6q0ft0 37 14 adding add VBG cord-005687-gj6q0ft0 37 15 direct direct JJ cord-005687-gj6q0ft0 37 16 molecular molecular JJ cord-005687-gj6q0ft0 37 17 detection detection NN cord-005687-gj6q0ft0 37 18 of of IN cord-005687-gj6q0ft0 37 19 pathogens pathogen NNS cord-005687-gj6q0ft0 37 20 in in IN cord-005687-gj6q0ft0 37 21 the the DT cord-005687-gj6q0ft0 37 22 blood blood NN cord-005687-gj6q0ft0 37 23 of of IN cord-005687-gj6q0ft0 37 24 patients patient NNS cord-005687-gj6q0ft0 37 25 hospitalized hospitalize VBN cord-005687-gj6q0ft0 37 26 with with IN cord-005687-gj6q0ft0 37 27 severe severe JJ cord-005687-gj6q0ft0 37 28 sepsis sepsis NN cord-005687-gj6q0ft0 37 29 to to IN cord-005687-gj6q0ft0 37 30 standard standard JJ cord-005687-gj6q0ft0 37 31 blood blood NN cord-005687-gj6q0ft0 37 32 cultures culture NNS cord-005687-gj6q0ft0 37 33 results result VBZ cord-005687-gj6q0ft0 37 34 in in IN cord-005687-gj6q0ft0 37 35 an an DT cord-005687-gj6q0ft0 37 36 overall overall JJ cord-005687-gj6q0ft0 37 37 higher high JJR cord-005687-gj6q0ft0 37 38 microbial microbial JJ cord-005687-gj6q0ft0 37 39 diagnosis diagnosis NN cord-005687-gj6q0ft0 37 40 rate rate NN cord-005687-gj6q0ft0 37 41 ( ( -LRB- cord-005687-gj6q0ft0 37 42 increase increase NN cord-005687-gj6q0ft0 37 43 from from IN cord-005687-gj6q0ft0 37 44 28.1 28.1 CD cord-005687-gj6q0ft0 37 45 to to IN cord-005687-gj6q0ft0 37 46 42.6 42.6 CD cord-005687-gj6q0ft0 37 47 % % NN cord-005687-gj6q0ft0 37 48 ) ) -RRB- cord-005687-gj6q0ft0 37 49 and and CC cord-005687-gj6q0ft0 37 50 shorter short JJR cord-005687-gj6q0ft0 37 51 time time NN cord-005687-gj6q0ft0 37 52 to to IN cord-005687-gj6q0ft0 37 53 results result NNS cord-005687-gj6q0ft0 37 54 ( ( -LRB- cord-005687-gj6q0ft0 37 55 22.9 22.9 CD cord-005687-gj6q0ft0 37 56 vs. vs. FW cord-005687-gj6q0ft0 37 57 49.5 49.5 CD cord-005687-gj6q0ft0 37 58 h h NNP cord-005687-gj6q0ft0 37 59 ) ) -RRB- cord-005687-gj6q0ft0 37 60 . . . cord-005687-gj6q0ft0 38 1 Given give VBN cord-005687-gj6q0ft0 38 2 higher high JJR cord-005687-gj6q0ft0 38 3 diagnostic diagnostic JJ cord-005687-gj6q0ft0 38 4 sensitivity sensitivity NN cord-005687-gj6q0ft0 38 5 and and CC cord-005687-gj6q0ft0 38 6 turnaround turnaround NN cord-005687-gj6q0ft0 38 7 , , , cord-005687-gj6q0ft0 38 8 do do VBP cord-005687-gj6q0ft0 38 9 the the DT cord-005687-gj6q0ft0 38 10 results result NNS cord-005687-gj6q0ft0 38 11 of of IN cord-005687-gj6q0ft0 38 12 the the DT cord-005687-gj6q0ft0 38 13 EVAMICA EVAMICA NNP cord-005687-gj6q0ft0 38 14 study study NN cord-005687-gj6q0ft0 38 15 indicate indicate VBP cord-005687-gj6q0ft0 38 16 that that IN cord-005687-gj6q0ft0 38 17 rapid rapid JJ cord-005687-gj6q0ft0 38 18 diagnostic diagnostic JJ cord-005687-gj6q0ft0 38 19 tests test NNS cord-005687-gj6q0ft0 38 20 be be VB cord-005687-gj6q0ft0 38 21 integrated integrate VBN cord-005687-gj6q0ft0 38 22 into into IN cord-005687-gj6q0ft0 38 23 standard standard JJ cord-005687-gj6q0ft0 38 24 diagnostic diagnostic JJ cord-005687-gj6q0ft0 38 25 laboratory laboratory NN cord-005687-gj6q0ft0 38 26 practice practice NN cord-005687-gj6q0ft0 38 27 ? ? . cord-005687-gj6q0ft0 39 1 There there EX cord-005687-gj6q0ft0 39 2 are be VBP cord-005687-gj6q0ft0 39 3 a a DT cord-005687-gj6q0ft0 39 4 number number NN cord-005687-gj6q0ft0 39 5 of of IN cord-005687-gj6q0ft0 39 6 considerations consideration NNS cord-005687-gj6q0ft0 39 7 for for IN cord-005687-gj6q0ft0 39 8 discussion discussion NN cord-005687-gj6q0ft0 39 9 in in IN cord-005687-gj6q0ft0 39 10 this this DT cord-005687-gj6q0ft0 39 11 regard regard NN cord-005687-gj6q0ft0 39 12 . . . cord-005687-gj6q0ft0 40 1 First first RB cord-005687-gj6q0ft0 40 2 , , , cord-005687-gj6q0ft0 40 3 it -PRON- PRP cord-005687-gj6q0ft0 40 4 is be VBZ cord-005687-gj6q0ft0 40 5 important important JJ cord-005687-gj6q0ft0 40 6 to to TO cord-005687-gj6q0ft0 40 7 recognize recognize VB cord-005687-gj6q0ft0 40 8 that that IN cord-005687-gj6q0ft0 40 9 , , , cord-005687-gj6q0ft0 40 10 while while IN cord-005687-gj6q0ft0 40 11 theoretically theoretically RB cord-005687-gj6q0ft0 40 12 the the DT cord-005687-gj6q0ft0 40 13 availability availability NN cord-005687-gj6q0ft0 40 14 of of IN cord-005687-gj6q0ft0 40 15 these these DT cord-005687-gj6q0ft0 40 16 results result NNS cord-005687-gj6q0ft0 40 17 should should MD cord-005687-gj6q0ft0 40 18 lead lead VB cord-005687-gj6q0ft0 40 19 to to IN cord-005687-gj6q0ft0 40 20 an an DT cord-005687-gj6q0ft0 40 21 increase increase NN cord-005687-gj6q0ft0 40 22 in in IN cord-005687-gj6q0ft0 40 23 targeted target VBN cord-005687-gj6q0ft0 40 24 and and CC cord-005687-gj6q0ft0 40 25 a a DT cord-005687-gj6q0ft0 40 26 reduction reduction NN cord-005687-gj6q0ft0 40 27 in in IN cord-005687-gj6q0ft0 40 28 excessive excessive JJ cord-005687-gj6q0ft0 40 29 or or CC cord-005687-gj6q0ft0 40 30 inadequate inadequate JJ cord-005687-gj6q0ft0 40 31 therapies therapy NNS cord-005687-gj6q0ft0 40 32 , , , cord-005687-gj6q0ft0 40 33 this this DT cord-005687-gj6q0ft0 40 34 study study NN cord-005687-gj6q0ft0 40 35 does do VBZ cord-005687-gj6q0ft0 40 36 not not RB cord-005687-gj6q0ft0 40 37 prove prove VB cord-005687-gj6q0ft0 40 38 this this DT cord-005687-gj6q0ft0 40 39 . . . cord-005687-gj6q0ft0 41 1 Second second RB cord-005687-gj6q0ft0 41 2 , , , cord-005687-gj6q0ft0 41 3 it -PRON- PRP cord-005687-gj6q0ft0 41 4 must must MD cord-005687-gj6q0ft0 41 5 be be VB cord-005687-gj6q0ft0 41 6 recognized recognize VBN cord-005687-gj6q0ft0 41 7 that that IN cord-005687-gj6q0ft0 41 8 for for IN cord-005687-gj6q0ft0 41 9 rapid rapid JJ cord-005687-gj6q0ft0 41 10 tests test NNS cord-005687-gj6q0ft0 41 11 to to TO cord-005687-gj6q0ft0 41 12 be be VB cord-005687-gj6q0ft0 41 13 most most RBS cord-005687-gj6q0ft0 41 14 useful useful JJ cord-005687-gj6q0ft0 41 15 they -PRON- PRP cord-005687-gj6q0ft0 41 16 should should MD cord-005687-gj6q0ft0 41 17 ideally ideally RB cord-005687-gj6q0ft0 41 18 be be VB cord-005687-gj6q0ft0 41 19 offered offer VBN cord-005687-gj6q0ft0 41 20 24 24 CD cord-005687-gj6q0ft0 41 21 h h NN cord-005687-gj6q0ft0 41 22 per per IN cord-005687-gj6q0ft0 41 23 day day NN cord-005687-gj6q0ft0 41 24 , , , cord-005687-gj6q0ft0 41 25 7 7 CD cord-005687-gj6q0ft0 41 26 days day NNS cord-005687-gj6q0ft0 41 27 a a DT cord-005687-gj6q0ft0 41 28 week week NN cord-005687-gj6q0ft0 41 29 . . . cord-005687-gj6q0ft0 42 1 In in IN cord-005687-gj6q0ft0 42 2 the the DT cord-005687-gj6q0ft0 42 3 EVAM EVAM NNP cord-005687-gj6q0ft0 42 4 - - HYPH cord-005687-gj6q0ft0 42 5 ICA ICA NNP cord-005687-gj6q0ft0 42 6 study study NN cord-005687-gj6q0ft0 42 7 , , , cord-005687-gj6q0ft0 42 8 tests test NNS cord-005687-gj6q0ft0 42 9 were be VBD cord-005687-gj6q0ft0 42 10 not not RB cord-005687-gj6q0ft0 42 11 offered offer VBN cord-005687-gj6q0ft0 42 12 at at IN cord-005687-gj6q0ft0 42 13 weekends weekend NNS cord-005687-gj6q0ft0 42 14 and and CC cord-005687-gj6q0ft0 42 15 were be VBD cord-005687-gj6q0ft0 42 16 batched batch VBN cord-005687-gj6q0ft0 42 17 for for IN cord-005687-gj6q0ft0 42 18 daily daily JJ cord-005687-gj6q0ft0 42 19 runs run NNS cord-005687-gj6q0ft0 42 20 . . . cord-005687-gj6q0ft0 43 1 Whether whether IN cord-005687-gj6q0ft0 43 2 many many JJ cord-005687-gj6q0ft0 43 3 clinical clinical JJ cord-005687-gj6q0ft0 43 4 laboratories laboratory NNS cord-005687-gj6q0ft0 43 5 could could MD cord-005687-gj6q0ft0 43 6 implement implement VB cord-005687-gj6q0ft0 43 7 this this DT cord-005687-gj6q0ft0 43 8 test test NN cord-005687-gj6q0ft0 43 9 for for IN cord-005687-gj6q0ft0 43 10 provision provision NN cord-005687-gj6q0ft0 43 11 of of IN cord-005687-gj6q0ft0 43 12 prompt prompt JJ cord-005687-gj6q0ft0 43 13 results result NNS cord-005687-gj6q0ft0 43 14 in in IN cord-005687-gj6q0ft0 43 15 the the DT cord-005687-gj6q0ft0 43 16 " " `` cord-005687-gj6q0ft0 43 17 real real JJ cord-005687-gj6q0ft0 43 18 world world NN cord-005687-gj6q0ft0 43 19 " " '' cord-005687-gj6q0ft0 43 20 setting set VBG cord-005687-gj6q0ft0 43 21 remains remain VBZ cord-005687-gj6q0ft0 43 22 to to TO cord-005687-gj6q0ft0 43 23 be be VB cord-005687-gj6q0ft0 43 24 determined determine VBN cord-005687-gj6q0ft0 43 25 . . . cord-005687-gj6q0ft0 44 1 Third third RB cord-005687-gj6q0ft0 44 2 , , , cord-005687-gj6q0ft0 44 3 while while IN cord-005687-gj6q0ft0 44 4 a a DT cord-005687-gj6q0ft0 44 5 significant significant JJ cord-005687-gj6q0ft0 44 6 improvement improvement NN cord-005687-gj6q0ft0 44 7 in in IN cord-005687-gj6q0ft0 44 8 diagnostic diagnostic JJ cord-005687-gj6q0ft0 44 9 certainty certainty NN cord-005687-gj6q0ft0 44 10 was be VBD cord-005687-gj6q0ft0 44 11 observed observe VBN cord-005687-gj6q0ft0 44 12 , , , cord-005687-gj6q0ft0 44 13 the the DT cord-005687-gj6q0ft0 44 14 fact fact NN cord-005687-gj6q0ft0 44 15 that that IN cord-005687-gj6q0ft0 44 16 the the DT cord-005687-gj6q0ft0 44 17 majority majority NN cord-005687-gj6q0ft0 44 18 remained remain VBD cord-005687-gj6q0ft0 44 19 undiagnosed undiagnosed JJ cord-005687-gj6q0ft0 44 20 for for IN cord-005687-gj6q0ft0 44 21 an an DT cord-005687-gj6q0ft0 44 22 infecting infect VBG cord-005687-gj6q0ft0 44 23 etiology etiology NN cord-005687-gj6q0ft0 44 24 leaves leave NNS cord-005687-gj6q0ft0 44 25 much much JJ cord-005687-gj6q0ft0 44 26 to to TO cord-005687-gj6q0ft0 44 27 be be VB cord-005687-gj6q0ft0 44 28 desired desire VBN cord-005687-gj6q0ft0 44 29 . . . cord-005687-gj6q0ft0 45 1 So so RB cord-005687-gj6q0ft0 45 2 is be VBZ cord-005687-gj6q0ft0 45 3 it -PRON- PRP cord-005687-gj6q0ft0 45 4 time time NN cord-005687-gj6q0ft0 45 5 for for IN cord-005687-gj6q0ft0 45 6 it -PRON- PRP cord-005687-gj6q0ft0 45 7 ? ? . cord-005687-gj6q0ft0 46 1 Yes yes UH cord-005687-gj6q0ft0 46 2 ! ! . cord-005687-gj6q0ft0 47 1 It -PRON- PRP cord-005687-gj6q0ft0 47 2 is be VBZ cord-005687-gj6q0ft0 47 3 our -PRON- PRP$ cord-005687-gj6q0ft0 47 4 contention contention NN cord-005687-gj6q0ft0 47 5 that that IN cord-005687-gj6q0ft0 47 6 realtime realtime NN cord-005687-gj6q0ft0 47 7 PCR PCR NNP cord-005687-gj6q0ft0 47 8 should should MD cord-005687-gj6q0ft0 47 9 be be VB cord-005687-gj6q0ft0 47 10 incorporated incorporate VBN cord-005687-gj6q0ft0 47 11 into into IN cord-005687-gj6q0ft0 47 12 standard standard JJ cord-005687-gj6q0ft0 47 13 clinical clinical JJ cord-005687-gj6q0ft0 47 14 management management NN cord-005687-gj6q0ft0 47 15 of of IN cord-005687-gj6q0ft0 47 16 patients patient NNS cord-005687-gj6q0ft0 47 17 with with IN cord-005687-gj6q0ft0 47 18 sepsis sepsis NN cord-005687-gj6q0ft0 47 19 . . . cord-005687-gj6q0ft0 48 1 However however RB cord-005687-gj6q0ft0 48 2 , , , cord-005687-gj6q0ft0 48 3 use use NN cord-005687-gj6q0ft0 48 4 of of IN cord-005687-gj6q0ft0 48 5 these these DT cord-005687-gj6q0ft0 48 6 tests test NNS cord-005687-gj6q0ft0 48 7 will will MD cord-005687-gj6q0ft0 48 8 still still RB cord-005687-gj6q0ft0 48 9 require require VB cord-005687-gj6q0ft0 48 10 adjunct adjunct JJ cord-005687-gj6q0ft0 48 11 use use NN cord-005687-gj6q0ft0 48 12 of of IN cord-005687-gj6q0ft0 48 13 standard standard JJ cord-005687-gj6q0ft0 48 14 blood blood NN cord-005687-gj6q0ft0 48 15 culture culture NN cord-005687-gj6q0ft0 48 16 methods method NNS cord-005687-gj6q0ft0 48 17 and and CC cord-005687-gj6q0ft0 48 18 , , , cord-005687-gj6q0ft0 48 19 for for IN cord-005687-gj6q0ft0 48 20 full full JJ cord-005687-gj6q0ft0 48 21 benefit benefit NN cord-005687-gj6q0ft0 48 22 implementation implementation NN cord-005687-gj6q0ft0 48 23 , , , cord-005687-gj6q0ft0 48 24 coupling couple VBG cord-005687-gj6q0ft0 48 25 with with IN cord-005687-gj6q0ft0 48 26 AST AST NNP cord-005687-gj6q0ft0 48 27 . . . cord-005687-gj6q0ft0 49 1 We -PRON- PRP cord-005687-gj6q0ft0 49 2 must must MD cord-005687-gj6q0ft0 49 3 recognize recognize VB cord-005687-gj6q0ft0 49 4 that that DT cord-005687-gj6q0ft0 49 5 , , , cord-005687-gj6q0ft0 49 6 even even RB cord-005687-gj6q0ft0 49 7 with with IN cord-005687-gj6q0ft0 49 8 the the DT cord-005687-gj6q0ft0 49 9 important important JJ cord-005687-gj6q0ft0 49 10 gains gain NNS cord-005687-gj6q0ft0 49 11 we -PRON- PRP cord-005687-gj6q0ft0 49 12 have have VBP cord-005687-gj6q0ft0 49 13 witnessed witness VBN cord-005687-gj6q0ft0 49 14 with with IN cord-005687-gj6q0ft0 49 15 the the DT cord-005687-gj6q0ft0 49 16 use use NN cord-005687-gj6q0ft0 49 17 of of IN cord-005687-gj6q0ft0 49 18 new new JJ cord-005687-gj6q0ft0 49 19 diagnostic diagnostic JJ cord-005687-gj6q0ft0 49 20 tests test NNS cord-005687-gj6q0ft0 49 21 , , , cord-005687-gj6q0ft0 49 22 the the DT cord-005687-gj6q0ft0 49 23 majority majority NN cord-005687-gj6q0ft0 49 24 of of IN cord-005687-gj6q0ft0 49 25 patients patient NNS cord-005687-gj6q0ft0 49 26 with with IN cord-005687-gj6q0ft0 49 27 sepsis sepsis NN cord-005687-gj6q0ft0 49 28 will will MD cord-005687-gj6q0ft0 49 29 remain remain VB cord-005687-gj6q0ft0 49 30 undiagnosed undiagnosed JJ cord-005687-gj6q0ft0 49 31 for for IN cord-005687-gj6q0ft0 49 32 a a DT cord-005687-gj6q0ft0 49 33 specific specific JJ cord-005687-gj6q0ft0 49 34 etiology etiology NN cord-005687-gj6q0ft0 49 35 . . . cord-005687-gj6q0ft0 50 1 Research research NN cord-005687-gj6q0ft0 50 2 into into IN cord-005687-gj6q0ft0 50 3 further further RB cord-005687-gj6q0ft0 50 4 improving improve VBG cord-005687-gj6q0ft0 50 5 diagnostic diagnostic JJ cord-005687-gj6q0ft0 50 6 certainty certainty NN cord-005687-gj6q0ft0 50 7 through through IN cord-005687-gj6q0ft0 50 8 ongoing ongoing JJ cord-005687-gj6q0ft0 50 9 development development NN cord-005687-gj6q0ft0 50 10 of of IN cord-005687-gj6q0ft0 50 11 rapid rapid JJ cord-005687-gj6q0ft0 50 12 culture culture NN cord-005687-gj6q0ft0 50 13 - - HYPH cord-005687-gj6q0ft0 50 14 independent independent JJ cord-005687-gj6q0ft0 50 15 microbiological microbiological JJ cord-005687-gj6q0ft0 50 16 identification identification NN cord-005687-gj6q0ft0 50 17 methods method NNS cord-005687-gj6q0ft0 50 18 , , , cord-005687-gj6q0ft0 50 19 means mean VBZ cord-005687-gj6q0ft0 50 20 to to TO cord-005687-gj6q0ft0 50 21 enhance enhance VB cord-005687-gj6q0ft0 50 22 swift swift JJ cord-005687-gj6q0ft0 50 23 communication communication NN cord-005687-gj6q0ft0 50 24 of of IN cord-005687-gj6q0ft0 50 25 results result NNS cord-005687-gj6q0ft0 50 26 between between IN cord-005687-gj6q0ft0 50 27 microbiology microbiology NN cord-005687-gj6q0ft0 50 28 laboratory laboratory NN cord-005687-gj6q0ft0 50 29 and and CC cord-005687-gj6q0ft0 50 30 the the DT cord-005687-gj6q0ft0 50 31 ICU ICU NNP cord-005687-gj6q0ft0 50 32 , , , cord-005687-gj6q0ft0 50 33 and and CC cord-005687-gj6q0ft0 50 34 enhanced enhanced JJ cord-005687-gj6q0ft0 50 35 integration integration NN cord-005687-gj6q0ft0 50 36 with with IN cord-005687-gj6q0ft0 50 37 AST AST NNP cord-005687-gj6q0ft0 50 38 is be VBZ cord-005687-gj6q0ft0 50 39 needed need VBN cord-005687-gj6q0ft0 50 40 to to TO cord-005687-gj6q0ft0 50 41 improve improve VB cord-005687-gj6q0ft0 50 42 individual individual JJ cord-005687-gj6q0ft0 50 43 patient patient JJ cord-005687-gj6q0ft0 50 44 outcomes outcome NNS cord-005687-gj6q0ft0 50 45 and and CC cord-005687-gj6q0ft0 50 46 reduce reduce VB cord-005687-gj6q0ft0 50 47 the the DT cord-005687-gj6q0ft0 50 48 burden burden NN cord-005687-gj6q0ft0 50 49 of of IN cord-005687-gj6q0ft0 50 50 excessive excessive JJ cord-005687-gj6q0ft0 50 51 antibiotic antibiotic JJ cord-005687-gj6q0ft0 50 52 use use NN cord-005687-gj6q0ft0 50 53 and and CC cord-005687-gj6q0ft0 50 54 subsequent subsequent JJ cord-005687-gj6q0ft0 50 55 emergence emergence NN cord-005687-gj6q0ft0 50 56 of of IN cord-005687-gj6q0ft0 50 57 antimicrobial antimicrobial JJ cord-005687-gj6q0ft0 50 58 resistance resistance NN cord-005687-gj6q0ft0 50 59 . . . cord-005687-gj6q0ft0 51 1 Effectiveness effectiveness NN cord-005687-gj6q0ft0 51 2 of of IN cord-005687-gj6q0ft0 51 3 practices practice NNS cord-005687-gj6q0ft0 51 4 to to TO cord-005687-gj6q0ft0 51 5 increase increase VB cord-005687-gj6q0ft0 51 6 timeliness timeliness NN cord-005687-gj6q0ft0 51 7 of of IN cord-005687-gj6q0ft0 51 8 providing provide VBG cord-005687-gj6q0ft0 51 9 targeted target VBN cord-005687-gj6q0ft0 51 10 therapy therapy NN cord-005687-gj6q0ft0 51 11 for for IN cord-005687-gj6q0ft0 51 12 inpatients inpatient NNS cord-005687-gj6q0ft0 51 13 with with IN cord-005687-gj6q0ft0 51 14 bloodstream bloodstream NN cord-005687-gj6q0ft0 51 15 infections infection NNS cord-005687-gj6q0ft0 51 16 : : : cord-005687-gj6q0ft0 51 17 a a DT cord-005687-gj6q0ft0 51 18 laboratory laboratory NN cord-005687-gj6q0ft0 51 19 medicine medicine NN cord-005687-gj6q0ft0 51 20 best good JJS cord-005687-gj6q0ft0 51 21 practices practice NNS cord-005687-gj6q0ft0 51 22 systematic systematic JJ cord-005687-gj6q0ft0 51 23 review review NN cord-005687-gj6q0ft0 51 24 and and CC cord-005687-gj6q0ft0 51 25 meta meta NNP cord-005687-gj6q0ft0 51 26 - - HYPH cord-005687-gj6q0ft0 51 27 analysis analysis NN cord-005687-gj6q0ft0 51 28 Impact Impact NNP cord-005687-gj6q0ft0 51 29 of of IN cord-005687-gj6q0ft0 51 30 rapid rapid JJ cord-005687-gj6q0ft0 51 31 organism organism NN cord-005687-gj6q0ft0 51 32 identification identification NN cord-005687-gj6q0ft0 51 33 via via IN cord-005687-gj6q0ft0 51 34 matrix matrix NN cord-005687-gj6q0ft0 51 35 - - HYPH cord-005687-gj6q0ft0 51 36 assisted assist VBN cord-005687-gj6q0ft0 51 37 laser laser NN cord-005687-gj6q0ft0 51 38 desorption desorption NN cord-005687-gj6q0ft0 51 39 / / SYM cord-005687-gj6q0ft0 51 40 ionization ionization NN cord-005687-gj6q0ft0 51 41 time time NN cord-005687-gj6q0ft0 51 42 - - HYPH cord-005687-gj6q0ft0 51 43 of of IN cord-005687-gj6q0ft0 51 44 - - HYPH cord-005687-gj6q0ft0 51 45 flight flight NN cord-005687-gj6q0ft0 51 46 combined combine VBN cord-005687-gj6q0ft0 51 47 with with IN cord-005687-gj6q0ft0 51 48 antimicrobial antimicrobial JJ cord-005687-gj6q0ft0 51 49 stewardship stewardship NN cord-005687-gj6q0ft0 51 50 team team NN cord-005687-gj6q0ft0 51 51 intervention intervention NN cord-005687-gj6q0ft0 51 52 in in IN cord-005687-gj6q0ft0 51 53 adult adult NN cord-005687-gj6q0ft0 51 54 patients patient NNS cord-005687-gj6q0ft0 51 55 with with IN cord-005687-gj6q0ft0 51 56 bacteremia bacteremia NN cord-005687-gj6q0ft0 51 57 and and CC cord-005687-gj6q0ft0 51 58 candidemia candidemia NN cord-005687-gj6q0ft0 51 59 Impact Impact NNP cord-005687-gj6q0ft0 51 60 of of IN cord-005687-gj6q0ft0 51 61 Matrix Matrix NNP cord-005687-gj6q0ft0 51 62 - - HYPH cord-005687-gj6q0ft0 51 63 Assisted Assisted NNP cord-005687-gj6q0ft0 51 64 Laser Laser NNP cord-005687-gj6q0ft0 51 65 Desorption Desorption NNP cord-005687-gj6q0ft0 51 66 and and CC cord-005687-gj6q0ft0 51 67 Ionization Ionization NNP cord-005687-gj6q0ft0 51 68 Time Time NNP cord-005687-gj6q0ft0 51 69 - - HYPH cord-005687-gj6q0ft0 51 70 of of IN cord-005687-gj6q0ft0 51 71 - - HYPH cord-005687-gj6q0ft0 51 72 Flight Flight NNP cord-005687-gj6q0ft0 51 73 and and CC cord-005687-gj6q0ft0 51 74 Antimicrobial Antimicrobial NNP cord-005687-gj6q0ft0 51 75 Stewardship Stewardship NNP cord-005687-gj6q0ft0 51 76 Intervention Intervention NNP cord-005687-gj6q0ft0 51 77 on on IN cord-005687-gj6q0ft0 51 78 Treatment Treatment NNP cord-005687-gj6q0ft0 51 79 of of IN cord-005687-gj6q0ft0 51 80 Bloodstream bloodstream NN cord-005687-gj6q0ft0 51 81 Infections infection NNS cord-005687-gj6q0ft0 51 82 in in IN cord-005687-gj6q0ft0 51 83 Hospitalized Hospitalized NNP cord-005687-gj6q0ft0 51 84 Children Children NNPS cord-005687-gj6q0ft0 51 85 Evaluation Evaluation NNP cord-005687-gj6q0ft0 51 86 of of IN cord-005687-gj6q0ft0 51 87 matrix matrix NN cord-005687-gj6q0ft0 51 88 - - HYPH cord-005687-gj6q0ft0 51 89 assisted assist VBN cord-005687-gj6q0ft0 51 90 laser laser NN cord-005687-gj6q0ft0 51 91 desorption desorption NN cord-005687-gj6q0ft0 51 92 ionization ionization NN cord-005687-gj6q0ft0 51 93 - - HYPH cord-005687-gj6q0ft0 51 94 time time NN cord-005687-gj6q0ft0 51 95 of of IN cord-005687-gj6q0ft0 51 96 flight flight NN cord-005687-gj6q0ft0 51 97 mass mass NN cord-005687-gj6q0ft0 51 98 spectrometry spectrometry NN cord-005687-gj6q0ft0 51 99 for for IN cord-005687-gj6q0ft0 51 100 rapid rapid JJ cord-005687-gj6q0ft0 51 101 detection detection NN cord-005687-gj6q0ft0 51 102 of of IN cord-005687-gj6q0ft0 51 103 β β NN cord-005687-gj6q0ft0 51 104 - - HYPH cord-005687-gj6q0ft0 51 105 lactam lactam NN cord-005687-gj6q0ft0 51 106 resistance resistance NN cord-005687-gj6q0ft0 51 107 in in IN cord-005687-gj6q0ft0 51 108 Enterobacteriaceae Enterobacteriaceae NNP cord-005687-gj6q0ft0 51 109 derived derive VBN cord-005687-gj6q0ft0 51 110 from from IN cord-005687-gj6q0ft0 51 111 blood blood NN cord-005687-gj6q0ft0 51 112 cultures culture NNS cord-005687-gj6q0ft0 52 1 Community community NN cord-005687-gj6q0ft0 52 2 - - HYPH cord-005687-gj6q0ft0 52 3 acquired acquire VBN cord-005687-gj6q0ft0 52 4 pneumonia pneumonia NN cord-005687-gj6q0ft0 52 5 related relate VBN cord-005687-gj6q0ft0 52 6 to to IN cord-005687-gj6q0ft0 52 7 intracellular intracellular JJ cord-005687-gj6q0ft0 52 8 pathogens pathogen NNS cord-005687-gj6q0ft0 52 9 Diagnostic diagnostic JJ cord-005687-gj6q0ft0 52 10 workup workup NN cord-005687-gj6q0ft0 52 11 for for IN cord-005687-gj6q0ft0 52 12 ARDS ARDS NNP cord-005687-gj6q0ft0 52 13 patients patient NNS cord-005687-gj6q0ft0 52 14 Impact Impact NNP cord-005687-gj6q0ft0 52 15 of of IN cord-005687-gj6q0ft0 52 16 bronchoalveolar bronchoalveolar NNP cord-005687-gj6q0ft0 52 17 lavage lavage NN cord-005687-gj6q0ft0 52 18 multiplex multiplex NN cord-005687-gj6q0ft0 52 19 polymerase polymerase NN cord-005687-gj6q0ft0 52 20 chain chain NN cord-005687-gj6q0ft0 52 21 reaction reaction NN cord-005687-gj6q0ft0 52 22 on on IN cord-005687-gj6q0ft0 52 23 microbiological microbiological JJ cord-005687-gj6q0ft0 52 24 yield yield NN cord-005687-gj6q0ft0 52 25 and and CC cord-005687-gj6q0ft0 52 26 therapeutic therapeutic JJ cord-005687-gj6q0ft0 52 27 decisions decision NNS cord-005687-gj6q0ft0 52 28 in in IN cord-005687-gj6q0ft0 52 29 severe severe JJ cord-005687-gj6q0ft0 52 30 pneumonia pneumonia NN cord-005687-gj6q0ft0 52 31 in in IN cord-005687-gj6q0ft0 52 32 intensive intensive JJ cord-005687-gj6q0ft0 52 33 care care NN cord-005687-gj6q0ft0 52 34 unit unit NN cord-005687-gj6q0ft0 52 35 Diagnostic diagnostic JJ cord-005687-gj6q0ft0 52 36 accuracy accuracy NN cord-005687-gj6q0ft0 52 37 of of IN cord-005687-gj6q0ft0 52 38 SeptiFast SeptiFast NNP cord-005687-gj6q0ft0 52 39 multi multi JJ cord-005687-gj6q0ft0 52 40 - - JJ cord-005687-gj6q0ft0 52 41 pathogen pathogen JJ cord-005687-gj6q0ft0 52 42 real real JJ cord-005687-gj6q0ft0 52 43 - - HYPH cord-005687-gj6q0ft0 52 44 time time NN cord-005687-gj6q0ft0 52 45 PCR PCR NNP cord-005687-gj6q0ft0 52 46 in in IN cord-005687-gj6q0ft0 52 47 the the DT cord-005687-gj6q0ft0 52 48 setting setting NN cord-005687-gj6q0ft0 52 49 of of IN cord-005687-gj6q0ft0 52 50 suspected suspect VBN cord-005687-gj6q0ft0 52 51 healthcare healthcare NN cord-005687-gj6q0ft0 52 52 - - HYPH cord-005687-gj6q0ft0 52 53 associated associate VBN cord-005687-gj6q0ft0 52 54 bloodstream bloodstream NN cord-005687-gj6q0ft0 52 55 infection infection NN cord-005687-gj6q0ft0 52 56 Accuracy accuracy NN cord-005687-gj6q0ft0 52 57 of of IN cord-005687-gj6q0ft0 52 58 Light Light NNP cord-005687-gj6q0ft0 52 59 - - HYPH cord-005687-gj6q0ft0 52 60 Cycler Cycler NNP cord-005687-gj6q0ft0 52 61 SeptiFast SeptiFast NNP cord-005687-gj6q0ft0 52 62 for for IN cord-005687-gj6q0ft0 52 63 the the DT cord-005687-gj6q0ft0 52 64 detection detection NN cord-005687-gj6q0ft0 52 65 and and CC cord-005687-gj6q0ft0 52 66 identification identification NN cord-005687-gj6q0ft0 52 67 of of IN cord-005687-gj6q0ft0 52 68 pathogens pathogen NNS cord-005687-gj6q0ft0 52 69 in in IN cord-005687-gj6q0ft0 52 70 the the DT cord-005687-gj6q0ft0 52 71 blood blood NN cord-005687-gj6q0ft0 52 72 of of IN cord-005687-gj6q0ft0 52 73 patients patient NNS cord-005687-gj6q0ft0 52 74 with with IN cord-005687-gj6q0ft0 52 75 suspected suspect VBN cord-005687-gj6q0ft0 52 76 sepsis sepsis NN cord-005687-gj6q0ft0 52 77 : : : cord-005687-gj6q0ft0 52 78 a a DT cord-005687-gj6q0ft0 52 79 systematic systematic JJ cord-005687-gj6q0ft0 52 80 review review NN cord-005687-gj6q0ft0 52 81 and and CC cord-005687-gj6q0ft0 52 82 metaanalysis metaanalysis NN cord-005687-gj6q0ft0 52 83 Multi multi JJ cord-005687-gj6q0ft0 52 84 - - HYPH cord-005687-gj6q0ft0 52 85 pathogen pathogen NN cord-005687-gj6q0ft0 52 86 real real JJ cord-005687-gj6q0ft0 52 87 - - HYPH cord-005687-gj6q0ft0 52 88 time time NN cord-005687-gj6q0ft0 52 89 PCR PCR NNP cord-005687-gj6q0ft0 52 90 system system NN cord-005687-gj6q0ft0 52 91 adds add VBZ cord-005687-gj6q0ft0 52 92 benefit benefit NN cord-005687-gj6q0ft0 52 93 for for IN cord-005687-gj6q0ft0 52 94 my -PRON- PRP$ cord-005687-gj6q0ft0 52 95 patients patient NNS cord-005687-gj6q0ft0 52 96 : : : cord-005687-gj6q0ft0 52 97 yes yes UH cord-005687-gj6q0ft0 52 98 Rapid rapid JJ cord-005687-gj6q0ft0 52 99 diagnosis diagnosis NN cord-005687-gj6q0ft0 52 100 of of IN cord-005687-gj6q0ft0 52 101 infection infection NN cord-005687-gj6q0ft0 52 102 in in IN cord-005687-gj6q0ft0 52 103 the the DT cord-005687-gj6q0ft0 52 104 critically critically RB cord-005687-gj6q0ft0 52 105 ill ill JJ cord-005687-gj6q0ft0 52 106 , , , cord-005687-gj6q0ft0 52 107 a a DT cord-005687-gj6q0ft0 52 108 multicenter multicenter JJ cord-005687-gj6q0ft0 52 109 study study NN cord-005687-gj6q0ft0 52 110 of of IN cord-005687-gj6q0ft0 52 111 molecular molecular JJ cord-005687-gj6q0ft0 52 112 detection detection NN cord-005687-gj6q0ft0 52 113 in in IN cord-005687-gj6q0ft0 52 114 bloodstream bloodstream NN cord-005687-gj6q0ft0 52 115 infections infection NNS cord-005687-gj6q0ft0 52 116 , , , cord-005687-gj6q0ft0 52 117 pneumonia pneumonia NN cord-005687-gj6q0ft0 52 118 , , , cord-005687-gj6q0ft0 52 119 and and CC cord-005687-gj6q0ft0 52 120 sterile sterile JJ cord-005687-gj6q0ft0 52 121 site site NN cord-005687-gj6q0ft0 52 122 infections infection NNS cord-005687-gj6q0ft0 53 1 Randomized randomized JJ cord-005687-gj6q0ft0 53 2 trial trial NN cord-005687-gj6q0ft0 53 3 of of IN cord-005687-gj6q0ft0 53 4 rapid rapid JJ cord-005687-gj6q0ft0 53 5 multiplex multiplex NN cord-005687-gj6q0ft0 53 6 polymerase polymerase NN cord-005687-gj6q0ft0 53 7 chain chain NN cord-005687-gj6q0ft0 53 8 reaction reaction NN cord-005687-gj6q0ft0 53 9 - - HYPH cord-005687-gj6q0ft0 53 10 based base VBN cord-005687-gj6q0ft0 53 11 blood blood NN cord-005687-gj6q0ft0 53 12 culture culture NN cord-005687-gj6q0ft0 53 13 identification identification NN cord-005687-gj6q0ft0 53 14 and and CC cord-005687-gj6q0ft0 53 15 susceptibility susceptibility NN cord-005687-gj6q0ft0 53 16 testing testing NN cord-005687-gj6q0ft0 53 17 Performance performance NN cord-005687-gj6q0ft0 53 18 and and CC cord-005687-gj6q0ft0 53 19 economic economic JJ cord-005687-gj6q0ft0 53 20 evaluation evaluation NN cord-005687-gj6q0ft0 53 21 of of IN cord-005687-gj6q0ft0 53 22 the the DT cord-005687-gj6q0ft0 53 23 molecular molecular JJ cord-005687-gj6q0ft0 53 24 detection detection NN cord-005687-gj6q0ft0 53 25 of of IN cord-005687-gj6q0ft0 53 26 pathogens pathogen NNS cord-005687-gj6q0ft0 53 27 for for IN cord-005687-gj6q0ft0 53 28 patients patient NNS cord-005687-gj6q0ft0 53 29 with with IN cord-005687-gj6q0ft0 53 30 severe severe JJ cord-005687-gj6q0ft0 53 31 infections infection NNS cord-005687-gj6q0ft0 53 32 : : : cord-005687-gj6q0ft0 53 33 the the DT cord-005687-gj6q0ft0 53 34 EVAMICA EVAMICA NNP cord-005687-gj6q0ft0 53 35 open open JJ cord-005687-gj6q0ft0 53 36 - - HYPH cord-005687-gj6q0ft0 53 37 label label NN cord-005687-gj6q0ft0 53 38 cluster cluster NN cord-005687-gj6q0ft0 53 39 - - HYPH cord-005687-gj6q0ft0 53 40 randomised randomised JJ cord-005687-gj6q0ft0 53 41 interventional interventional JJ cord-005687-gj6q0ft0 53 42 crossover crossover NN cord-005687-gj6q0ft0 53 43 trial trial NN