id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001039-qocuprwb	Hayasaka, Daisuke	TNF-α Acts as an Immunoregulator in the Mouse Brain by Reducing the Incidence of Severe Disease Following Japanese Encephalitis Virus Infection	2013-08-05		.txt	text/plain	8562	464	51	We next compared severe or mild cases of mice infected with JEV exhibiting doseindependent mortality and investigated the specific host responses such as TNF-α and IL-10 expression in the CNS. Corresponding to the viral loads, histopathological examination showed that a large number of neurons displayed JEV antigens and severe cuffing was observed in the brain cortex of JaTH160-infected mice at 9 day pi ( Figure 1F ). Following inoculation with JaOArS982 virus, there were no significant differences of infectious viral loads in the brain cortex between WT, IL-10 KO and TNF-α KO at 5, 9 and 11 days pi ( Figure 5B ). TNF-α KO mice exhibited significantly increased levels of IFN-γ and IL-5 in the brains compared with WT and/or IL-10 KO mice at 5 and 7 days pi following JaTH160 inoculation ( Figure 7C and D) .	./cache/cord-001039-qocuprwb.txt	./txt/cord-001039-qocuprwb.txt