id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002326-3qb1ym4w	Yang, Runkuan	Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries	2016-12-03		.txt	text/plain	7622	310	36	EP (40 mg/kg) was intraperitoneally injected every 6 h for 48 h)] significantly ameliorates pancreatic injury and necrosis [4, 6] ; EP therapy also markedly reduces pancreatic expression of TNF-α, IL-6, HMGB1 and NF-kB DNA binding [4, 6] ; treatment with EP reduces the number of inflammatory cell infiltration and decreases the pancreatic level of lipid peroxidation, which is a parameter of ROS [4] . Hepatic I/R induces significantly increased hepatic expression of TNF-α, IL-6, HMGB1 and NF-kB activation, and hepatic I/R also induces markedly increased hepatic expression of Bcl-2, Bax, Beclin-1 and LC3, which play an important role in the regulation of intrinsic pathway of apoptosis and autophagy, all of these changes are significantly reduced by EP treatment (1 h before the ischemia procedure, a single dose of EP was intraperitoneally injected to animals in the 20 mg/kg group, the 40 mg/kg group and the 80 mg/kg group, liver tissue samples were obtained 4 h, 6 h and 16 h after I/R), suggesting that EP ameliorates hepatic I/R injury via its antiinflammatory and its anti-apoptosis effect.	./cache/cord-002326-3qb1ym4w.txt	./txt/cord-002326-3qb1ym4w.txt