id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016168-3hyb9stq	nan	Pathogenesis of Fever	2009		.txt	text/plain	4067	272	45	• Fever (pyrexia) is a regulated body temperature above the normal range occurring as a result of IL-1-mediated elevation of the hypothalamic set point. • Cytokines are proteins produced throughout the body, mainly by monocytes, macrophages, and T cells to regulate the immune responses within the body and control inflammatory and haematopoietic processes and may induce fever. • Pro-inflammatory cytokines (IL-1, IL-6, TNF-α, INF-γ, granulocyte-macrophage colony-stimulating factor, GM-CSF) are responsible for initiating an effective defense against exogenous organisms. Other mechanisms to initiate fever include the following: Some endotoxins, produced by bacteria, act directly on the hypothalamus to alter the set point. Mechanisms by which viruses may produce fever include direct invasion of macrophages, immunological reaction to viral components involving antibody formation, induction by INF, and necrosis of cells by viruses. Increased TNF production in Kawasaki disease may play a role in the immune activation and damage to vascular endothelial cells occurring in the disease.	./cache/cord-016168-3hyb9stq.txt	./txt/cord-016168-3hyb9stq.txt