id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016523-pznw2ciu	Fouqué, Amélie	The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis	2014-08-29		.txt	text/plain	8777	427	41	During interactions with respective ligands, members of the death receptor superfamily recruit adaptor proteins such as Fas-associating protein with a death domain (FADD) [ 7 , 8 ] or tumor necrosis factor (TNF) receptor 1-associated death domain protein (TRADD) [ 9 ] , resulting in the aggregation and activation of the initiator caspase-8 and caspase-10 to form the death-inducing signaling complex (DISC) [ 10 ] . These type I transmembrane proteins share common features, such as extracellular amino-terminal cysteine-rich domains (CRDs) [ 19 , 20 ] , which contribute to ligand specifi city [ 21 ] , and preassociation of the receptor at the plasma membrane [ 22 -24 ] and a conserved 80 amino acid sequence located in their cytoplasmic tail called death domain (DD), which is necessary for DISC formation and initiation of the apoptotic signal [ 25 , 26 ] .	./cache/cord-016523-pznw2ciu.txt	./txt/cord-016523-pznw2ciu.txt