id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017520-r786yd6i	Huber-Lang, Markus	Inflammatory Changes and Coagulopathy in Multiply Injured Patients	2015-05-14		.txt	text/plain	7032	356	34	Severe tissue trauma leads to an early activation of several danger recognition systems, including the complement and the coagulation system, often resulting in an overwhelming almost synchronic proand anti-inflammatory response of the host. Although the immune response is associated with beneficial effects at the site of injury including the elimination of exogenous and endogenous danger molecules as well as the initiation of regenerative processes, an exaggerated systemic inflammatory response significantly contributes to posttraumatic complications such as multiple organ failure (MOF) and early death. The steps of an inflammatory reaction to trauma involve fluid phase mediators (cytokines, chemokines, coagulation-and complement activation products, oxygen radicals, eicosanoids, and nitric oxide (NO)) and cellular effectors (neutrophils, monocytes/macrophages, and endothelial cells) that translate the trauma-induced signals into cellular responses.	./cache/cord-017520-r786yd6i.txt	./txt/cord-017520-r786yd6i.txt