id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017639-wtc8bml5	El-Radhi, A. Sahib	Pathogenesis of Fever	2019-01-02		.txt	text/plain	5141	346	44	The induction of fever results in inhibition of bacterial growth, increased bactericidal effects of neutrophils, production of acute-phase protein synthesis and other physiological changes such as anorexia and somnolence. • Cytokines are proteins produced throughout the body, mainly by activated macrophages, monocytes and T cells to regulate the immune responses within the body, control inflammatory and haematopoietic processes and may induce fever. Pro-inflammatory cytokines (e.g. IL-1, IL-6, TNF-α, INF-γ, granulocytes-macrophages colony stimulating factor, GM-CSF) are responsible for initiating an effective defence against exogenous organisms (e.g. activating neutrophils). • Exogenous pyrogens initiate fever by inducing host cells (primarily macrophages) to produce and release endogenous pyrogens such as interleukin-1, which has multiple biological functions essential for the immune response. • Exogenous pyrogens initiate fever by inducing host cells (primarily macrophages) to produce and release endogenous pyrogens such as interleukin-1, which has multiple biological functions essential for the immune response.	./cache/cord-017639-wtc8bml5.txt	./txt/cord-017639-wtc8bml5.txt