id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017640-i8h48ny6	Fouqué, Amélie	The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis	2020-01-03		.txt	text/plain	8811	419	39	The intrinsic pathway stems from accumulation of DNA damage, deregulation of mitochondrial function, or virus infection and induces the release of proapoptotic factors from the mitochondria, whereas extrinsic signals are transmitted by the binding of apoptotic ligands to death receptors present at the cell surface. During interactions with respective ligands, members of the death receptor superfamily recruit adaptor proteins such as Fas-associated protein with a death domain (FADD) [7, 8] or tumor necrosis factor (TNF) receptor 1-associated death domain protein (TRADD) [9] , resulting in the aggregation and activation of the initiators caspase-8 and caspase-10 to form the death-inducing signaling complex (DISC) [10] . These type I transmembrane proteins share common features, such as extracellular amino-terminal cysteine-rich domains (CRDs) [19, 20] , which contribute to ligand specificity [21] , and pre-association of the receptor at the plasma membrane [22] [23] [24] and a conserved 80-amino acid sequence located in their cytoplasmic tail called death domain (DD), which is necessary for DISC formation and initiation of the apoptotic signal [25, 26] .	./cache/cord-017640-i8h48ny6.txt	./txt/cord-017640-i8h48ny6.txt