id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022631-s4n24xij	Jonsson, M. V.	Germinal Centres in Primary Sjögren's Syndrome Indicate a Certain Clinical Immunological Phenotype	2008-06-28		.txt	text/plain	16905	873	46	We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus.	./cache/cord-022631-s4n24xij.txt	./txt/cord-022631-s4n24xij.txt