id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-023950-nv0pbbu2	Schnyder, Bruno	Dual Role of Th17 Cytokines, IL-17A,F, and IL-22 in Allergic Asthma	2012-07-19		.txt	text/plain	4439	245	41	Unchecked activation of Th17 cells by IL-23 is linked to chronic inflammation in experimental autoimmune encephalomyelitis (EAE) and type II collagen-induced arthritis, two heretofore prototypical "Th1" disease models [6, 7] . Furthermore, Murdoch and Lloyd provide evidence in the model of acute allergen-induced response that the gdT cell-dependent normalization of lung function and resolution of inflammation was dependent on the production of IL-17 [16] . These data provide evidence that IL-17A,F and IL-22 besides their inflammatory role have a negative regulatory function in allergic lung inflammation. On a mechanistic level, IL-17A elicits dual effects and reportedly promotes expression of proinflammatory (hemopoietic, CXC-chemokines, acute phase) factors [54, 55] , whereas it inhibits the production of mononuclear cell recruiting molecules like TNF-induced VCAM-1 and CC-chemokine RANTES [35] . IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation	./cache/cord-023950-nv0pbbu2.txt	./txt/cord-023950-nv0pbbu2.txt