id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259586-kep2dgaw	Van Reeth, Kristien	In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome but rewarding	2002-09-10		.txt	text/plain	4193	231	49	This review concentrates on in vivo studies of cytokine involvement in infectious respiratory diseases of swine, with an emphasis on viral infections. In the authors' laboratory, studies were undertaken to investigate the relationship between viral respiratory disease and bioactive lung lavage levels of IFN-α, TNF-α, IL-1 and IL-6. We have previously demonstrated different cytokine pro-®les in BAL¯uids of gnotobiotic pigs infected with porcine respiratory coronavirus (PRCV), porcine reproductive and respiratory syndrome virus (PRRSV) or swine in¯uenza virus (SIV) (Van Reeth et al., 1999) . In an attempt to study interactions between respiratory viruses and secondary agents in a reproducible way, we have performed subsequent inoculations of pigs with either PRCV or PRRSV followed by bacterial lipopolysaccharide (LPS). Prior infection with PRCV truly potentiated the cytokine response to LPS, with 10±100 times higher titres of TNF-a, IL-1 and IL-6 than after the respective single inoculations. Differential production of proin¯ammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity	./cache/cord-259586-kep2dgaw.txt	./txt/cord-259586-kep2dgaw.txt