id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262511-96xp1v0r	Khabar, Khalid S. A.	Rapid transit in the immune cells: the role of mRNA turnover regulation	2007-03-30		.txt	text/plain	6542	342	43	Post-transcriptional regulation contributes significantly to this rapid transit by several mechanisms, including mRNA stability modulation and translational control; collectively, they aim to control the expression of key gene products involved in the immune response. The stabilization of cytokine mRNA and other immune response gene products can occur by the activity of mRNA stabilization-promoting proteins such as human antigen (HuR) protein or by inactivation of RNA decay-promoting proteins such as the zinc finger protein, tristetraprolin (TTP). Traditionally, post-transcriptional regulation in innate immunity has been studied in response to the bacterial endotoxin, LPS, which binds CD14 in a complex with TLR4 on the surface of neutrophils and macrophages and initiates a cascade of signals that causes cell activation, the inflammatory response, and phagocytosis [35] . With the coordinated kinetics model, stabilizing RNA-binding proteins such as HuR can occur initially following immune cell activation, allowing rapid and early response of cytokine production.	./cache/cord-262511-96xp1v0r.txt	./txt/cord-262511-96xp1v0r.txt