id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275730-650sjwyy	Gogoi, Himanshu	The Age of Cyclic Dinucleotide Vaccine Adjuvants	2020-08-13		.txt	text/plain	8347	519	50	As therapeutic cancer vaccine adjuvants, CDNs induce potent anti-tumor immunity, including cytotoxic T cells and NK cells activation that achieve durable regression in multiple mouse models of tumors. (STINGel) Synthetic ML-RpRp-SS-CDA in multidomain peptide hydrogel (s.c.) [60] Slow-release of CDN and highly effective in maintaining tumor clearance and rejecting tumor growth and provide durable anti-tumor immunity CDG in YSK05 liposome (s.c.) [61] Activation of antigen-specific CTL activity and restrict murine tumor growth completely ADU-S100 (Synthetic ML-RpRp-SS-CDA) in combination with anti-PD1 or anti-CTLA4 antibody (intratumoral) [62] Low-dosage promotes local STING activation primarily in monocytic cell lineages whereas a high-dose resulted in cellular activation at distal sites A combination of ADU-S100 and α-CPI provide durable immunity even against cold tumors Synthetic RpRp-SS-CDG and ML-RpRp-CDA in PBAE nanoparticles and anti-PD1 antibody (intratumoral) [56] Enhanced shelf-life stability for up to nine months.	./cache/cord-275730-650sjwyy.txt	./txt/cord-275730-650sjwyy.txt