id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279498-ez3yq7xi	Suzumura, Akio	Immune Response in the Brain: Glial Response and Cytokine Production	2008-12-31		.txt	text/plain	5319	308	45	Cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and interleukin (IL)-3 induce class I major histocompatibility complex (MHC) antigen expression on neural cells. In the brains of experimental allergic encephalomyelitis (EAE), microglia near the infiltrating T cells are reported to be class II MHC antigen-positive [6] [7] [8] , suggesting that a T cell-derived cytokine, most probably IFN-g, can induce class II MHC antigen expression in vivo as well. Since the BBB is not damaged in this experimental condition and since there is no definitive evidence that neural cells produce INF-g in the CNS, it is unlikely that IFN-g is responsible for the induction of class II MHC antigen expression in this model. In contrast to IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF) downregulates IFN-g-induced class II MHC antigen expression in microglia. IL-10 suppresses cytokine production and IFN-g-induced class II MHC antigen expression in microglia, but does not suppress the proliferation or the activation of lysosomal enzymes in microglia [18] .	./cache/cord-279498-ez3yq7xi.txt	./txt/cord-279498-ez3yq7xi.txt