id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283246-dj7teo89	Otsuka, Ryo	Macrophage activation syndrome and COVID-19	2020-08-06		.txt	text/plain	3224	177	37	Still, it is possible that the causative virus for COVID-19, SARS-CoV-2, infect with particular types of cells such as endothelial vessels in the lung, or alveolar wall or macrophages. MAS is typified by markedly upregulated expression of pro-inflammatory cytokines, which is called "cytokine storm." Without any therapeutic intervention, this strong inflammation results in severe tissue injury and, ultimately, patient death. Thus, the commencement of local inflammation induced by SARS-CoV-2 infection activates macrophages at that site, spreading rapidly to the entire lung, possibly due to the abundant expression of virus entry receptors, ACE2 and TMPRSS2 [36] . Severe cases of COVID-19 are often observed with ARDS, representing the MAS-like clinical and laboratory features. The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: a single center study of 100 patients in	./cache/cord-283246-dj7teo89.txt	./txt/cord-283246-dj7teo89.txt