id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295683-eoxxal8v	Gong, R.	Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin	2006-04-01		.txt	text/plain	4481	266	42	This study examined the effect of HGF on endothelial E-selectin expression in acute inflammation induced by tumor necrosis factor (TNF)-α. In vitro, HGF suppressed TNF-α-induced cell surface expression of E-selectin in human umbilical vein endothelial cells (HUVEC) and inhibited E-selectin mediated monocytic adhesion to endothelial monolayers. In addition, selective inhibition of GSK3 activity by lithium suppressed TNF-α-induced E-selectin expression and monocytic adhesion, reminiscent of the action of HGF. [6] [7] [8] [9] [10] In the present study, we found that HGF suppresses monocyte to endothelial adhesion and attenuates acute renal inflammation via inhibition of endothelial E-selectin expression. In our study, HGF was found to suppress endothelial E-selectin expression in cultured HUVEC cells and in vivo in rats injected with TNF-a. In summary, HGF suppresses E-selectin expression in the activated endothelium and thereby attenuates monocyte to endothelial adhesion and alleviates acute inflammation in the kidney.	./cache/cord-295683-eoxxal8v.txt	./txt/cord-295683-eoxxal8v.txt