id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295745-iw3ftw3h	Gershoni, Jonathan M	Molecular decoys: antidotes, therapeutics and immunomodulators	2008-11-18		.txt	text/plain	5546	276	42	Decoys not only provide the means to fine tune the regulation of these phenomena; they also serve as potential leads for the development of recombinant anti-toxins, anti-viral agents and novel therapeutics for combating cancer and inflammatory disease. For almost every membrane receptor of cytokines, growth factors and cell adhesins, soluble versions were found to be naturally produced by cells; hence 'natural decoys' that function as modifiers of the potent stimulants and regulators of inflammation and immune response. Telovamer, a soluble, high molecular weight anionic polymer represents a 'functional decoy' able to bind and neutralize both Toxin A and Toxin B of Clostridium difficile yet is not derived from the natural receptor for these toxins. Nature produces such soluble receptors in order to crucially regulate immune responses towards cancer and infection as well as inflammation in general (Figure 1 ). This is particularly relevant for chemokine receptors whose decoys persist as membrane proteins that are effective in ligand binding but 'handicapped' in signal transduction.	./cache/cord-295745-iw3ftw3h.txt	./txt/cord-295745-iw3ftw3h.txt