id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302258-derq9b27	Zhang, Hui	Effects of ubiquitin-proteasome inhibitor on the expression levels of TNF-α and TGF-β1 in mice with viral myocarditis	2019-08-14		.txt	text/plain	3444	201	56	Effects of ubiquitin-proteasome system (UPS) inhibitor MG-132 on the expression levels of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in mice with viral myocarditis were investigated to analyze the correlation of myocardial tissue score of mice between TNF-α and TGF-β1. Mortality rates of each group were recorded and compared on day 8 of modeling, and heart specimens from the remaining mice were histopathologically examined and the expression of mRNA and protein of TNF-α and TGF-β1 in myocardial tissues were detected by western blot analysis. The expression levels of myocardial histopathological scores, mRNA and protein of TNF-α and TGF-β1 in the blank and control group were significantly lower than those in the VMC and the MG-132 group. At present, few studies have reported the role of UPS in the inflammatory reaction of VMC, so we explored the effect of ubiquitin-proteasome inhibitor MG-23 on the expression levels of serum TNF-α and TGF-β1 in CVB mice, in order to understand the inflammatory mechanism of VMC.	./cache/cord-302258-derq9b27.txt	./txt/cord-302258-derq9b27.txt