id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308008-s2t11l3h	Limonta, Daniel	Apoptotic mediators in patients with severe and non‐severe dengue from Brazil	2013-10-29		.txt	text/plain	6077	320	49	Therefore, plasma levels of the three proapoptotic mediators Fas ligand (FasL), tumor necrosis factor-a (TNF-a), and TNF-related apoptosis-inducing ligand (TRAIL) were measured in dengue patients. Previous studies of dengue infection have shown apoptosis in lymphocytes [Mongkolsapaya et al., 2003; Myint et al., 2006] , monocytes [Torrentes-Carvalho et al., 2009; Levy et al., 2010] , and peripheral blood mononuclear cells (PBMCs) [Jaiyen et al., 2009] . The other proteins studied, plasma Survivin and PBMCs lysate proteins, are IAPs. Our data suggest that TRAIL could be involved with apoptosis induction of blood lymphocytes and could also contribute to the antiviral response. In the present study, elevated TRAIL levels were observed in patients with dengue without warning signs compared to those with severe dengue and control subjects. The findings in the present work, which used the revised WHO dengue classification, suggest that the antiviral action of TRAIL that was shown previously in cell culture [Warke et al., 2008b] , may also occur in vivo and hence the likely increased severity of dengue in patients lacking an elevated TRAIL production.	./cache/cord-308008-s2t11l3h.txt	./txt/cord-308008-s2t11l3h.txt