id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324949-sqy03dks	Poe, Francis L.	N-Acetylcysteine: a potential therapeutic agent for SARS-CoV-2	2020-05-30		.txt	text/plain	3485	208	47	In vivo, in vitro, and human clinical trials have demonstrated N-acetylcysteine (NAC) as an effective method of improving redox status, especially when under oxidative stress. Mediation of the viral load could occur through NAC's ability to increase cellular redox status via maximizing the rate limiting step of glutathione synthesis, and thereby potentially decreasing the effects of virally induced oxidative stress and cell death. The pathogenic factors of SARS-CoV-2 that could possibly be mediated by NAC are (1) T cell exhaustion, which manifests as lower counts and decreased functional capacity of CD4+ and CD8+ cells; (2) pro-inflammatory state via increase in TNF-ɑ, IL1β, IL18; and (3) modulation of viral activity through increased glutathione. Mediation of the viral load could occur through the ability of NAC to increase cellular redox status by maximizing the rate limiting step of glutathione synthesis, and thereby decreasing the effects of virally induced oxidative stress and cell death.	./cache/cord-324949-sqy03dks.txt	./txt/cord-324949-sqy03dks.txt