id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330549-ppuqvafd	Christophi, George P.	Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype	2009-04-27		.txt	text/plain	9832	494	43	Supporting a direct role of SHP-1 deficiency in altered macrophage function, experimental depletion of SHP-1 in normal subject macrophages resulted in an increased STAT/NF-κB activation and increased inflammatory gene expression to levels seen in macrophages of MS patients. Supporting a direct role of SHP-1 deficiency in altered macrophage function, experimental depletion of SHP-1 in macrophages of normal human subjects using siRNA resulted in an increased activation of the above transcription factors and increased inflammatory gene expression to levels seen in macrophages of MS patients. In order to determine whether increased activation of STAT6, STAT1, and NF-κB in macrophages of MS patients relative to normal subjects corresponded to heightened expression of STAT6-, STAT1-, and NF-κB responsive genes, the mRNA levels of several genes were quantified following 18-hour treatment with several cytokines (Figure 6 ).	./cache/cord-330549-ppuqvafd.txt	./txt/cord-330549-ppuqvafd.txt