id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332071-bqvn3ceq	Lee, Jeong Seok	Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19	2020-07-10		.txt	text/plain	7099	412	53	In a murine model of SARS-CoV infection, a delayed, but considerable type I IFN (IFN-I) response CORONAVIRUS Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 (Page numbers not final at time of first release) 2 promotes the accumulation of monocytes-macrophages and the production of pro-inflammatory cytokines, resulting in lethal pneumonia with vascular leakage and impaired virusspecific T-cell responses (10) . To examine the host immune responses in a cell type-specific manner, we subjected 59,572 cells to t-distributed stochastic neighbor embedding (tSNE) based on highly variable genes using the Seurat package (17) and identified 22 different clusters unbiased by patients or experimental batches of scRNA-seq (Fig. 1A, Fig. S1D ). First, we combined both mild and severe COVID-19 as a COVID-19 group and identified disease-specific changes in genes for each cell type compared to the healthy donor group using model-based analysis of single cell transcriptomics (MAST) (18) .	./cache/cord-332071-bqvn3ceq.txt	./txt/cord-332071-bqvn3ceq.txt