id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339272-trd6rkxw	Chen, Na	Prime-O-glucosylcimifugin attenuates lipopolysaccharide-induced acute lung injury in mice	2013-04-24		.txt	text/plain	4313	225	47	The purpose of this study was to evaluate the effect of prime-O-glucosylcimifugin on acute lung injury (ALI) induced by lipopolysaccharide in mice. LPS-induced ALI is considered a neutrophil-dependent ALI that contributes to local recruitment and activation of neutrophils [8] ; the release of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6; and the formation of reactive oxygen and nitrogen species [9] [10] [11] . Therefore, with a mouse model of acute lung inflammation, the present study was undertaken to examine the effect of Prime-O-glucosylcimifugin on acute lung injury induced by intranasal instillation of LPS in BALB/c mice and investigate its possible mechanisms. Acute lung injury is characterized by systemic airway inflammatory response including cytokines (e.g., TNF-α, IL-6, IL-8), chemokines, pro-inflammatory mediators and a variety of cells, which regulate the migration and pulmonary infiltration of neutrophils into the interstitial tissue [34] .	./cache/cord-339272-trd6rkxw.txt	./txt/cord-339272-trd6rkxw.txt