id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344204-qq2vqzc2	Hariharan, Apurva	The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients	2020-11-07		.txt	text/plain	5647	307	47	Severe presentations of COVID-19 such as severe pneumonia and acute respiratory distress syndrome (ARDS) have been associated with the post-viral activation and release of cytokine/chemokines which leads to a "cytokine storm" causing inflammatory response and destruction, mainly affecting the lungs. Immunomodulation at the level of NF-κB activation and inhibitors of NF-κB (IκB) degradation along with TNF-α inhibition will potentially result in a reduction in the cytokine storm and alleviate the severity of COVID-19. During previous coronavirus outbreaks, such as SARS-CoV and the Middle East Respiratory syndrome coronavirus (MERS-CoV) , it was reported that viral proteins such as nsp1, nsp3a, nsp7a, spike, and nucleocapsid protein all caused excessive NF-κB activation, possibly contributing to severe disease and high case-fatality rate (DeDiego et al. Herein, we review current literature on the effect of SARS-nCoV-2 infection on NF-κB activation and discuss the potential therapeutic role of inhibitors of this pathway in the treatment of COVID-19.	./cache/cord-344204-qq2vqzc2.txt	./txt/cord-344204-qq2vqzc2.txt