id	sid	tid	token	lemma	pos
cord-001293-dfaxj3bv	1	1	key	key	NN
cord-001293-dfaxj3bv	1	2	:	:	:
cord-001293-dfaxj3bv	2	1	cord-001293-dfaxj3bv	cord-001293-dfaxj3bv	NNP
cord-001293-dfaxj3bv	3	1	authors	author	NNS
cord-001293-dfaxj3bv	3	2	:	:	:
cord-001293-dfaxj3bv	3	3	Cavaillon	Cavaillon	NNP
cord-001293-dfaxj3bv	3	4	,	,	,
cord-001293-dfaxj3bv	3	5	Jean	Jean	NNP
cord-001293-dfaxj3bv	3	6	-	-	HYPH
cord-001293-dfaxj3bv	3	7	Marc	Marc	NNP
cord-001293-dfaxj3bv	3	8	;	;	:
cord-001293-dfaxj3bv	3	9	Eisen	Eisen	NNP
cord-001293-dfaxj3bv	3	10	,	,	,
cord-001293-dfaxj3bv	3	11	Damon	Damon	NNP
cord-001293-dfaxj3bv	3	12	;	;	:
cord-001293-dfaxj3bv	3	13	Annane	Annane	NNP
cord-001293-dfaxj3bv	3	14	,	,	,
cord-001293-dfaxj3bv	3	15	Djilalli	Djilalli	NNP
cord-001293-dfaxj3bv	3	16	title	title	NN
cord-001293-dfaxj3bv	3	17	:	:	:
cord-001293-dfaxj3bv	3	18	Is	be	VBZ
cord-001293-dfaxj3bv	3	19	boosting	boost	VBG
cord-001293-dfaxj3bv	3	20	the	the	DT
cord-001293-dfaxj3bv	3	21	immune	immune	JJ
cord-001293-dfaxj3bv	3	22	system	system	NN
cord-001293-dfaxj3bv	3	23	in	in	IN
cord-001293-dfaxj3bv	3	24	sepsis	sepsis	NN
cord-001293-dfaxj3bv	3	25	appropriate	appropriate	JJ
cord-001293-dfaxj3bv	3	26	?	?	.
cord-001293-dfaxj3bv	4	1	date	date	NN
cord-001293-dfaxj3bv	4	2	:	:	:
cord-001293-dfaxj3bv	4	3	2014	2014	CD
cord-001293-dfaxj3bv	4	4	-	-	HYPH
cord-001293-dfaxj3bv	4	5	03	03	CD
cord-001293-dfaxj3bv	4	6	-	-	HYPH
cord-001293-dfaxj3bv	4	7	24	24	CD
cord-001293-dfaxj3bv	4	8	journal	journal	NN
cord-001293-dfaxj3bv	4	9	:	:	:
cord-001293-dfaxj3bv	5	1	Crit	Crit	NNP
cord-001293-dfaxj3bv	5	2	Care	Care	NNP
cord-001293-dfaxj3bv	5	3	DOI	doi	NN
cord-001293-dfaxj3bv	5	4	:	:	:
cord-001293-dfaxj3bv	6	1	10.1186	10.1186	CD
cord-001293-dfaxj3bv	7	1	/cc13787	/cc13787	NFP
cord-001293-dfaxj3bv	7	2	sha	sha	NNP
cord-001293-dfaxj3bv	7	3	:	:	:
cord-001293-dfaxj3bv	7	4	5659e6b1f946e16554cab8f5a2711225a2a39985	5659e6b1f946e16554cab8f5a2711225a2a39985	CD
cord-001293-dfaxj3bv	8	1	doc_id	doc_id	CD
cord-001293-dfaxj3bv	8	2	:	:	:
cord-001293-dfaxj3bv	8	3	1293	1293	CD
cord-001293-dfaxj3bv	8	4	cord_uid	cord_uid	NNS
cord-001293-dfaxj3bv	8	5	:	:	:
cord-001293-dfaxj3bv	9	1	dfaxj3bv	dfaxj3bv	NNP
cord-001293-dfaxj3bv	10	1	A	a	DT
cord-001293-dfaxj3bv	10	2	relative	relative	JJ
cord-001293-dfaxj3bv	10	3	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	10	4	is	be	VBZ
cord-001293-dfaxj3bv	10	5	observed	observe	VBN
cord-001293-dfaxj3bv	10	6	in	in	IN
cord-001293-dfaxj3bv	10	7	patients	patient	NNS
cord-001293-dfaxj3bv	10	8	after	after	IN
cord-001293-dfaxj3bv	10	9	sepsis	sepsis	NN
cord-001293-dfaxj3bv	10	10	,	,	,
cord-001293-dfaxj3bv	10	11	trauma	trauma	NN
cord-001293-dfaxj3bv	10	12	,	,	,
cord-001293-dfaxj3bv	10	13	burns	burn	NNS
cord-001293-dfaxj3bv	10	14	,	,	,
cord-001293-dfaxj3bv	10	15	or	or	CC
cord-001293-dfaxj3bv	10	16	any	any	DT
cord-001293-dfaxj3bv	10	17	severe	severe	JJ
cord-001293-dfaxj3bv	10	18	insults	insult	NNS
cord-001293-dfaxj3bv	10	19	.	.	.
cord-001293-dfaxj3bv	11	1	It	-PRON-	PRP
cord-001293-dfaxj3bv	11	2	is	be	VBZ
cord-001293-dfaxj3bv	11	3	currently	currently	RB
cord-001293-dfaxj3bv	11	4	proposed	propose	VBN
cord-001293-dfaxj3bv	11	5	that	that	IN
cord-001293-dfaxj3bv	11	6	selected	select	VBN
cord-001293-dfaxj3bv	11	7	patients	patient	NNS
cord-001293-dfaxj3bv	11	8	will	will	MD
cord-001293-dfaxj3bv	11	9	benefit	benefit	VB
cord-001293-dfaxj3bv	11	10	from	from	IN
cord-001293-dfaxj3bv	11	11	treatment	treatment	NN
cord-001293-dfaxj3bv	11	12	aimed	aim	VBN
cord-001293-dfaxj3bv	11	13	at	at	IN
cord-001293-dfaxj3bv	11	14	boosting	boost	VBG
cord-001293-dfaxj3bv	11	15	their	-PRON-	PRP$
cord-001293-dfaxj3bv	11	16	immune	immune	JJ
cord-001293-dfaxj3bv	11	17	systems	system	NNS
cord-001293-dfaxj3bv	11	18	.	.	.
cord-001293-dfaxj3bv	12	1	However	however	RB
cord-001293-dfaxj3bv	12	2	,	,	,
cord-001293-dfaxj3bv	12	3	the	the	DT
cord-001293-dfaxj3bv	12	4	host	host	NN
cord-001293-dfaxj3bv	12	5	immune	immune	JJ
cord-001293-dfaxj3bv	12	6	response	response	NN
cord-001293-dfaxj3bv	12	7	needs	need	VBZ
cord-001293-dfaxj3bv	12	8	to	to	TO
cord-001293-dfaxj3bv	12	9	be	be	VB
cord-001293-dfaxj3bv	12	10	considered	consider	VBN
cord-001293-dfaxj3bv	12	11	in	in	IN
cord-001293-dfaxj3bv	12	12	context	context	NN
cord-001293-dfaxj3bv	12	13	with	with	IN
cord-001293-dfaxj3bv	12	14	pathogen	pathogen	NN
cord-001293-dfaxj3bv	12	15	-	-	HYPH
cord-001293-dfaxj3bv	12	16	type	type	NN
cord-001293-dfaxj3bv	12	17	,	,	,
cord-001293-dfaxj3bv	12	18	timing	timing	NN
cord-001293-dfaxj3bv	12	19	,	,	,
cord-001293-dfaxj3bv	12	20	and	and	CC
cord-001293-dfaxj3bv	12	21	mainly	mainly	RB
cord-001293-dfaxj3bv	12	22	tissue	tissue	NN
cord-001293-dfaxj3bv	12	23	specificity	specificity	NN
cord-001293-dfaxj3bv	12	24	.	.	.
cord-001293-dfaxj3bv	13	1	Indeed	indeed	RB
cord-001293-dfaxj3bv	13	2	,	,	,
cord-001293-dfaxj3bv	13	3	the	the	DT
cord-001293-dfaxj3bv	13	4	immune	immune	JJ
cord-001293-dfaxj3bv	13	5	status	status	NN
cord-001293-dfaxj3bv	13	6	of	of	IN
cord-001293-dfaxj3bv	13	7	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	13	8	is	be	VBZ
cord-001293-dfaxj3bv	13	9	not	not	RB
cord-001293-dfaxj3bv	13	10	universally	universally	RB
cord-001293-dfaxj3bv	13	11	decreased	decrease	VBN
cord-001293-dfaxj3bv	13	12	and	and	CC
cord-001293-dfaxj3bv	13	13	their	-PRON-	PRP$
cord-001293-dfaxj3bv	13	14	activated	activate	VBN
cord-001293-dfaxj3bv	13	15	status	status	NN
cord-001293-dfaxj3bv	13	16	in	in	IN
cord-001293-dfaxj3bv	13	17	tissues	tissue	NNS
cord-001293-dfaxj3bv	13	18	contributes	contribute	VBZ
cord-001293-dfaxj3bv	13	19	to	to	IN
cord-001293-dfaxj3bv	13	20	organ	organ	NN
cord-001293-dfaxj3bv	13	21	failure	failure	NN
cord-001293-dfaxj3bv	13	22	.	.	.
cord-001293-dfaxj3bv	14	1	Accordingly	accordingly	RB
cord-001293-dfaxj3bv	14	2	,	,	,
cord-001293-dfaxj3bv	14	3	any	any	DT
cord-001293-dfaxj3bv	14	4	new	new	JJ
cord-001293-dfaxj3bv	14	5	immune	immune	NN
cord-001293-dfaxj3bv	14	6	-	-	HYPH
cord-001293-dfaxj3bv	14	7	stimulatory	stimulatory	JJ
cord-001293-dfaxj3bv	14	8	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	14	9	intervention	intervention	NN
cord-001293-dfaxj3bv	14	10	should	should	MD
cord-001293-dfaxj3bv	14	11	take	take	VB
cord-001293-dfaxj3bv	14	12	into	into	IN
cord-001293-dfaxj3bv	14	13	consideration	consideration	NN
cord-001293-dfaxj3bv	14	14	potentially	potentially	RB
cord-001293-dfaxj3bv	14	15	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	14	16	effects	effect	NNS
cord-001293-dfaxj3bv	14	17	in	in	IN
cord-001293-dfaxj3bv	14	18	some	some	DT
cord-001293-dfaxj3bv	14	19	situations	situation	NNS
cord-001293-dfaxj3bv	14	20	.	.	.
cord-001293-dfaxj3bv	15	1	Refinements	refinement	NNS
cord-001293-dfaxj3bv	15	2	of	of	IN
cord-001293-dfaxj3bv	15	3	supportive	supportive	JJ
cord-001293-dfaxj3bv	15	4	care	care	NN
cord-001293-dfaxj3bv	15	5	of	of	IN
cord-001293-dfaxj3bv	15	6	patients	patient	NNS
cord-001293-dfaxj3bv	15	7	with	with	IN
cord-001293-dfaxj3bv	15	8	severe	severe	JJ
cord-001293-dfaxj3bv	15	9	sepsis	sepsis	NN
cord-001293-dfaxj3bv	15	10	have	have	VBP
cord-001293-dfaxj3bv	15	11	decreased	decrease	VBN
cord-001293-dfaxj3bv	15	12	their	-PRON-	PRP$
cord-001293-dfaxj3bv	15	13	overall	overall	JJ
cord-001293-dfaxj3bv	15	14	mortality	mortality	NN
cord-001293-dfaxj3bv	15	15	,	,	,
cord-001293-dfaxj3bv	15	16	but	but	CC
cord-001293-dfaxj3bv	15	17	no	no	DT
cord-001293-dfaxj3bv	15	18	adjuvant	adjuvant	JJ
cord-001293-dfaxj3bv	15	19	drug	drug	NN
cord-001293-dfaxj3bv	15	20	therapy	therapy	NN
cord-001293-dfaxj3bv	15	21	has	have	VBZ
cord-001293-dfaxj3bv	15	22	emerged	emerge	VBN
cord-001293-dfaxj3bv	15	23	despite	despite	IN
cord-001293-dfaxj3bv	15	24	strenuous	strenuous	JJ
cord-001293-dfaxj3bv	15	25	efforts	effort	NNS
cord-001293-dfaxj3bv	15	26	in	in	IN
cord-001293-dfaxj3bv	15	27	the	the	DT
cord-001293-dfaxj3bv	15	28	field	field	NN
cord-001293-dfaxj3bv	15	29	.	.	.
cord-001293-dfaxj3bv	16	1	Twenty	twenty	CD
cord-001293-dfaxj3bv	16	2	years	year	NNS
cord-001293-dfaxj3bv	16	3	have	have	VBP
cord-001293-dfaxj3bv	16	4	passed	pass	VBN
cord-001293-dfaxj3bv	16	5	since	since	IN
cord-001293-dfaxj3bv	16	6	the	the	DT
cord-001293-dfaxj3bv	16	7	first	first	JJ
cord-001293-dfaxj3bv	16	8	patients	patient	NNS
cord-001293-dfaxj3bv	16	9	with	with	IN
cord-001293-dfaxj3bv	16	10	sepsis	sepsis	NN
cord-001293-dfaxj3bv	16	11	were	be	VBD
cord-001293-dfaxj3bv	16	12	included	include	VBN
cord-001293-dfaxj3bv	16	13	in	in	IN
cord-001293-dfaxj3bv	16	14	clinical	clinical	JJ
cord-001293-dfaxj3bv	16	15	trials	trial	NNS
cord-001293-dfaxj3bv	16	16	based	base	VBN
cord-001293-dfaxj3bv	16	17	on	on	IN
cord-001293-dfaxj3bv	16	18	the	the	DT
cord-001293-dfaxj3bv	16	19	understanding	understanding	NN
cord-001293-dfaxj3bv	16	20	that	that	WDT
cord-001293-dfaxj3bv	16	21	TNF	TNF	NNP
cord-001293-dfaxj3bv	16	22	orchestrates	orchestrate	VBZ
cord-001293-dfaxj3bv	16	23	the	the	DT
cord-001293-dfaxj3bv	16	24	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	16	25	response	response	NN
cord-001293-dfaxj3bv	16	26	and	and	CC
cord-001293-dfaxj3bv	16	27	should	should	MD
cord-001293-dfaxj3bv	16	28	be	be	VB
cord-001293-dfaxj3bv	16	29	the	the	DT
cord-001293-dfaxj3bv	16	30	target	target	NN
cord-001293-dfaxj3bv	16	31	for	for	IN
cord-001293-dfaxj3bv	16	32	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	16	33	intervention	intervention	NN
cord-001293-dfaxj3bv	16	34	.	.	.
cord-001293-dfaxj3bv	17	1	In	in	IN
cord-001293-dfaxj3bv	17	2	response	response	NN
cord-001293-dfaxj3bv	17	3	to	to	IN
cord-001293-dfaxj3bv	17	4	the	the	DT
cord-001293-dfaxj3bv	17	5	failure	failure	NN
cord-001293-dfaxj3bv	17	6	of	of	IN
cord-001293-dfaxj3bv	17	7	therapies	therapy	NNS
cord-001293-dfaxj3bv	17	8	aiming	aim	VBG
cord-001293-dfaxj3bv	17	9	to	to	TO
cord-001293-dfaxj3bv	17	10	target	target	VB
cord-001293-dfaxj3bv	17	11	either	either	CC
cord-001293-dfaxj3bv	17	12	the	the	DT
cord-001293-dfaxj3bv	17	13	up	up	JJ
cord-001293-dfaxj3bv	17	14	-	-	HYPH
cord-001293-dfaxj3bv	17	15	stream	stream	NN
cord-001293-dfaxj3bv	17	16	microbial	microbial	JJ
cord-001293-dfaxj3bv	17	17	activators	activator	NNS
cord-001293-dfaxj3bv	17	18	or	or	CC
cord-001293-dfaxj3bv	17	19	the	the	DT
cord-001293-dfaxj3bv	17	20	effector	effector	JJ
cord-001293-dfaxj3bv	17	21	molecules	molecule	NNS
cord-001293-dfaxj3bv	17	22	of	of	IN
cord-001293-dfaxj3bv	17	23	the	the	DT
cord-001293-dfaxj3bv	17	24	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	17	25	cascade	cascade	NN
cord-001293-dfaxj3bv	17	26	,	,	,
cord-001293-dfaxj3bv	17	27	a	a	DT
cord-001293-dfaxj3bv	17	28	new	new	JJ
cord-001293-dfaxj3bv	17	29	concept	concept	NN
cord-001293-dfaxj3bv	17	30	has	have	VBZ
cord-001293-dfaxj3bv	17	31	emerged	emerge	VBN
cord-001293-dfaxj3bv	17	32	of	of	IN
cord-001293-dfaxj3bv	17	33	boosting	boost	VBG
cord-001293-dfaxj3bv	17	34	the	the	DT
cord-001293-dfaxj3bv	17	35	immune	immune	JJ
cord-001293-dfaxj3bv	17	36	system	system	NN
cord-001293-dfaxj3bv	17	37	to	to	TO
cord-001293-dfaxj3bv	17	38	counter	counter	VB
cord-001293-dfaxj3bv	17	39	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	17	40	that	that	WDT
cord-001293-dfaxj3bv	17	41	develops	develop	VBZ
cord-001293-dfaxj3bv	17	42	in	in	IN
cord-001293-dfaxj3bv	17	43	patients	patient	NNS
cord-001293-dfaxj3bv	17	44	who	who	WP
cord-001293-dfaxj3bv	17	45	survive	survive	VBP
cord-001293-dfaxj3bv	17	46	the	the	DT
cord-001293-dfaxj3bv	17	47	initial	initial	JJ
cord-001293-dfaxj3bv	17	48	,	,	,
cord-001293-dfaxj3bv	17	49	hyperinflammatory	hyperinflammatory	JJ
cord-001293-dfaxj3bv	17	50	period	period	NN
cord-001293-dfaxj3bv	17	51	of	of	IN
cord-001293-dfaxj3bv	17	52	sepsis	sepsis	NN
cord-001293-dfaxj3bv	17	53	[	[	-LRB-
cord-001293-dfaxj3bv	17	54	1	1	CD
cord-001293-dfaxj3bv	17	55	]	]	-RRB-
cord-001293-dfaxj3bv	17	56	.	.	.
cord-001293-dfaxj3bv	18	1	Inflammation	inflammation	NN
cord-001293-dfaxj3bv	18	2	is	be	VBZ
cord-001293-dfaxj3bv	18	3	a	a	DT
cord-001293-dfaxj3bv	18	4	highly	highly	RB
cord-001293-dfaxj3bv	18	5	sophisticated	sophisticated	JJ
cord-001293-dfaxj3bv	18	6	and	and	CC
cord-001293-dfaxj3bv	18	7	complex	complex	JJ
cord-001293-dfaxj3bv	18	8	response	response	NN
cord-001293-dfaxj3bv	18	9	that	that	WDT
cord-001293-dfaxj3bv	18	10	fundamentally	fundamentally	RB
cord-001293-dfaxj3bv	18	11	'	'	``
cord-001293-dfaxj3bv	18	12	aims	aim	VBZ
cord-001293-dfaxj3bv	18	13	'	'	''
cord-001293-dfaxj3bv	18	14	to	to	TO
cord-001293-dfaxj3bv	18	15	protect	protect	VB
cord-001293-dfaxj3bv	18	16	the	the	DT
cord-001293-dfaxj3bv	18	17	host	host	NN
cord-001293-dfaxj3bv	18	18	.	.	.
cord-001293-dfaxj3bv	19	1	In	in	IN
cord-001293-dfaxj3bv	19	2	this	this	DT
cord-001293-dfaxj3bv	19	3	review	review	NN
cord-001293-dfaxj3bv	19	4	,	,	,
cord-001293-dfaxj3bv	19	5	we	-PRON-	PRP
cord-001293-dfaxj3bv	19	6	argue	argue	VBP
cord-001293-dfaxj3bv	19	7	against	against	IN
cord-001293-dfaxj3bv	19	8	the	the	DT
cord-001293-dfaxj3bv	19	9	promulgation	promulgation	NN
cord-001293-dfaxj3bv	19	10	of	of	IN
cord-001293-dfaxj3bv	19	11	what	what	WP
cord-001293-dfaxj3bv	19	12	we	-PRON-	PRP
cord-001293-dfaxj3bv	19	13	believe	believe	VBP
cord-001293-dfaxj3bv	19	14	is	be	VBZ
cord-001293-dfaxj3bv	19	15	a	a	DT
cord-001293-dfaxj3bv	19	16	misleading	misleading	JJ
cord-001293-dfaxj3bv	19	17	perception	perception	NN
cord-001293-dfaxj3bv	19	18	of	of	IN
cord-001293-dfaxj3bv	19	19	sepsis	sepsis	NN
cord-001293-dfaxj3bv	19	20	inducing	induce	VBG
cord-001293-dfaxj3bv	19	21	secondary	secondary	JJ
cord-001293-dfaxj3bv	19	22	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	19	23	.	.	.
cord-001293-dfaxj3bv	20	1	The	the	DT
cord-001293-dfaxj3bv	20	2	possible	possible	JJ
cord-001293-dfaxj3bv	20	3	negative	negative	JJ
cord-001293-dfaxj3bv	20	4	consequences	consequence	NNS
cord-001293-dfaxj3bv	20	5	of	of	IN
cord-001293-dfaxj3bv	20	6	immune	immune	JJ
cord-001293-dfaxj3bv	20	7	system	system	NN
cord-001293-dfaxj3bv	20	8	-	-	HYPH
cord-001293-dfaxj3bv	20	9	boosting	boost	VBG
cord-001293-dfaxj3bv	20	10	therapy	therapy	NN
cord-001293-dfaxj3bv	20	11	are	be	VBP
cord-001293-dfaxj3bv	20	12	Paradoxical	paradoxical	JJ
cord-001293-dfaxj3bv	20	13	properties	property	NNS
cord-001293-dfaxj3bv	20	14	have	have	VBP
cord-001293-dfaxj3bv	20	15	also	also	RB
cord-001293-dfaxj3bv	20	16	been	be	VBN
cord-001293-dfaxj3bv	20	17	reported	report	VBN
cord-001293-dfaxj3bv	20	18	for	for	IN
cord-001293-dfaxj3bv	20	19	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	20	20	,	,	,
cord-001293-dfaxj3bv	20	21	the	the	DT
cord-001293-dfaxj3bv	20	22	prototypic	prototypic	JJ
cord-001293-dfaxj3bv	20	23	anti	anti	JJ
cord-001293-dfaxj3bv	20	24	-	-	JJ
cord-001293-dfaxj3bv	20	25	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	20	26	cytokine	cytokine	NN
cord-001293-dfaxj3bv	20	27	.	.	.
cord-001293-dfaxj3bv	21	1	Its	-PRON-	PRP$
cord-001293-dfaxj3bv	21	2	proinflammatory	proinflammatory	JJ
cord-001293-dfaxj3bv	21	3	activity	activity	NN
cord-001293-dfaxj3bv	21	4	been	be	VBN
cord-001293-dfaxj3bv	21	5	established	establish	VBN
cord-001293-dfaxj3bv	21	6	in	in	IN
cord-001293-dfaxj3bv	21	7	human	human	JJ
cord-001293-dfaxj3bv	21	8	volunteers	volunteer	NNS
cord-001293-dfaxj3bv	21	9	receiving	receive	VBG
cord-001293-dfaxj3bv	21	10	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	21	11	injection	injection	NN
cord-001293-dfaxj3bv	21	12	[	[	-LRB-
cord-001293-dfaxj3bv	21	13	6	6	CD
cord-001293-dfaxj3bv	21	14	]	]	-RRB-
cord-001293-dfaxj3bv	21	15	.	.	.
cord-001293-dfaxj3bv	22	1	Our	-PRON-	PRP$
cord-001293-dfaxj3bv	22	2	own	own	JJ
cord-001293-dfaxj3bv	22	3	in	in	FW
cord-001293-dfaxj3bv	22	4	vitro	vitro	FW
cord-001293-dfaxj3bv	22	5	studies	study	NNS
cord-001293-dfaxj3bv	22	6	showed	show	VBD
cord-001293-dfaxj3bv	22	7	that	that	IN
cord-001293-dfaxj3bv	22	8	adherence	adherence	NN
cord-001293-dfaxj3bv	22	9	of	of	IN
cord-001293-dfaxj3bv	22	10	human	human	JJ
cord-001293-dfaxj3bv	22	11	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	22	12	modulated	modulate	VBD
cord-001293-dfaxj3bv	22	13	the	the	DT
cord-001293-dfaxj3bv	22	14	effect	effect	NN
cord-001293-dfaxj3bv	22	15	of	of	IN
cord-001293-dfaxj3bv	22	16	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	22	17	on	on	IN
cord-001293-dfaxj3bv	22	18	expression	expression	NN
cord-001293-dfaxj3bv	22	19	of	of	IN
cord-001293-dfaxj3bv	22	20	16	16	CD
cord-001293-dfaxj3bv	22	21	genes	gene	NNS
cord-001293-dfaxj3bv	22	22	,	,	,
cord-001293-dfaxj3bv	22	23	including	include	VBG
cord-001293-dfaxj3bv	22	24	'	'	''
cord-001293-dfaxj3bv	22	25	suppressor	suppressor	NN
cord-001293-dfaxj3bv	22	26	of	of	IN
cord-001293-dfaxj3bv	22	27	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	22	28	stimulation	stimulation	NN
cord-001293-dfaxj3bv	22	29	'	'	''
cord-001293-dfaxj3bv	22	30	(	(	-LRB-
cord-001293-dfaxj3bv	22	31	SOCS	SOCS	NNP
cord-001293-dfaxj3bv	22	32	)	)	-RRB-
cord-001293-dfaxj3bv	22	33	molecules	molecule	NNS
cord-001293-dfaxj3bv	22	34	,	,	,
cord-001293-dfaxj3bv	22	35	in	in	IN
cord-001293-dfaxj3bv	22	36	the	the	DT
cord-001293-dfaxj3bv	22	37	opposite	opposite	JJ
cord-001293-dfaxj3bv	22	38	direction	direction	NN
cord-001293-dfaxj3bv	22	39	as	as	IN
cord-001293-dfaxj3bv	22	40	compared	compare	VBN
cord-001293-dfaxj3bv	22	41	with	with	IN
cord-001293-dfaxj3bv	22	42	non	non	JJ
cord-001293-dfaxj3bv	22	43	-	-	JJ
cord-001293-dfaxj3bv	22	44	adherent	adherent	JJ
cord-001293-dfaxj3bv	22	45	cells	cell	NNS
cord-001293-dfaxj3bv	22	46	[	[	-LRB-
cord-001293-dfaxj3bv	22	47	7	7	CD
cord-001293-dfaxj3bv	22	48	]	]	-RRB-
cord-001293-dfaxj3bv	22	49	.	.	.
cord-001293-dfaxj3bv	23	1	These	these	DT
cord-001293-dfaxj3bv	23	2	observations	observation	NNS
cord-001293-dfaxj3bv	23	3	illustrate	illustrate	VBP
cord-001293-dfaxj3bv	23	4	the	the	DT
cord-001293-dfaxj3bv	23	5	statement	statement	NN
cord-001293-dfaxj3bv	23	6	by	by	IN
cord-001293-dfaxj3bv	23	7	Moore	Moore	NNP
cord-001293-dfaxj3bv	23	8	and	and	CC
cord-001293-dfaxj3bv	23	9	colleagues	colleague	NNS
cord-001293-dfaxj3bv	23	10	that	that	DT
cord-001293-dfaxj3bv	23	11	'	'	``
cord-001293-dfaxj3bv	23	12	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	23	13	can	can	MD
cord-001293-dfaxj3bv	23	14	effect	effect	VB
cord-001293-dfaxj3bv	23	15	very	very	RB
cord-001293-dfaxj3bv	23	16	different	different	JJ
cord-001293-dfaxj3bv	23	17	outcomes	outcome	NNS
cord-001293-dfaxj3bv	23	18	depending	depend	VBG
cord-001293-dfaxj3bv	23	19	on	on	IN
cord-001293-dfaxj3bv	23	20	timing	timing	NN
cord-001293-dfaxj3bv	23	21	,	,	,
cord-001293-dfaxj3bv	23	22	dose	dose	NN
cord-001293-dfaxj3bv	23	23	,	,	,
cord-001293-dfaxj3bv	23	24	and	and	CC
cord-001293-dfaxj3bv	23	25	location	location	NN
cord-001293-dfaxj3bv	23	26	of	of	IN
cord-001293-dfaxj3bv	23	27	expression	expression	NN
cord-001293-dfaxj3bv	23	28	.	.	.
cord-001293-dfaxj3bv	24	1	In	in	IN
cord-001293-dfaxj3bv	24	2	some	some	DT
cord-001293-dfaxj3bv	24	3	scenarios	scenario	NNS
cord-001293-dfaxj3bv	24	4	,	,	,
cord-001293-dfaxj3bv	24	5	the	the	DT
cord-001293-dfaxj3bv	24	6	expected	expect	VBN
cord-001293-dfaxj3bv	24	7	immuno	immuno	JJ
cord-001293-dfaxj3bv	24	8	-	-	HYPH
cord-001293-dfaxj3bv	24	9	suppressive	suppressive	JJ
cord-001293-dfaxj3bv	24	10	activities	activity	NNS
cord-001293-dfaxj3bv	24	11	are	be	VBP
cord-001293-dfaxj3bv	24	12	observed	observe	VBN
cord-001293-dfaxj3bv	24	13	,	,	,
cord-001293-dfaxj3bv	24	14	while	while	IN
cord-001293-dfaxj3bv	24	15	in	in	IN
cord-001293-dfaxj3bv	24	16	others	other	NNS
cord-001293-dfaxj3bv	24	17	,	,	,
cord-001293-dfaxj3bv	24	18	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	24	19	enhances	enhance	VBZ
cord-001293-dfaxj3bv	24	20	immune	immune	JJ
cord-001293-dfaxj3bv	24	21	or	or	CC
cord-001293-dfaxj3bv	24	22	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	24	23	responses	response	NNS
cord-001293-dfaxj3bv	24	24	'	'	POS
cord-001293-dfaxj3bv	24	25	[	[	-LRB-
cord-001293-dfaxj3bv	24	26	8	8	CD
cord-001293-dfaxj3bv	24	27	]	]	-RRB-
cord-001293-dfaxj3bv	24	28	.	.	.
cord-001293-dfaxj3bv	25	1	Among	among	IN
cord-001293-dfaxj3bv	25	2	other	other	JJ
cord-001293-dfaxj3bv	25	3	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	25	4	classified	classify	VBN
cord-001293-dfaxj3bv	25	5	as	as	IN
cord-001293-dfaxj3bv	25	6	antiinflammatory	antiinflammatory	JJ
cord-001293-dfaxj3bv	25	7	,	,	,
cord-001293-dfaxj3bv	25	8	transforming	transform	VBG
cord-001293-dfaxj3bv	25	9	growth	growth	NN
cord-001293-dfaxj3bv	25	10	factor	factor	NN
cord-001293-dfaxj3bv	25	11	-	-	HYPH
cord-001293-dfaxj3bv	25	12	beta	beta	NN
cord-001293-dfaxj3bv	25	13	(	(	-LRB-
cord-001293-dfaxj3bv	25	14	TGFβ	TGFβ	NNP
cord-001293-dfaxj3bv	25	15	)	)	-RRB-
cord-001293-dfaxj3bv	25	16	may	may	MD
cord-001293-dfaxj3bv	25	17	behave	behave	VB
cord-001293-dfaxj3bv	25	18	as	as	IN
cord-001293-dfaxj3bv	25	19	pro	pro	JJ
cord-001293-dfaxj3bv	25	20	-	-	JJ
cord-001293-dfaxj3bv	25	21	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	25	22	mediator	mediator	NN
cord-001293-dfaxj3bv	25	23	as	as	IN
cord-001293-dfaxj3bv	25	24	TGFβtransgenic	TGFβtransgenic	NNP
cord-001293-dfaxj3bv	25	25	mice	mouse	NNS
cord-001293-dfaxj3bv	25	26	are	be	VBP
cord-001293-dfaxj3bv	25	27	more	more	RBR
cord-001293-dfaxj3bv	25	28	sensitive	sensitive	JJ
cord-001293-dfaxj3bv	25	29	to	to	IN
cord-001293-dfaxj3bv	25	30	LPS	LPS	NNP
cord-001293-dfaxj3bv	25	31	-	-	HYPH
cord-001293-dfaxj3bv	25	32	induced	induce	VBN
cord-001293-dfaxj3bv	25	33	shock	shock	NN
cord-001293-dfaxj3bv	25	34	[	[	-LRB-
cord-001293-dfaxj3bv	25	35	9	9	CD
cord-001293-dfaxj3bv	25	36	]	]	-RRB-
cord-001293-dfaxj3bv	25	37	and	and	CC
cord-001293-dfaxj3bv	25	38	some	some	DT
cord-001293-dfaxj3bv	25	39	of	of	IN
cord-001293-dfaxj3bv	25	40	its	-PRON-	PRP$
cord-001293-dfaxj3bv	25	41	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	25	42	activities	activity	NNS
cord-001293-dfaxj3bv	25	43	reflect	reflect	VBP
cord-001293-dfaxj3bv	25	44	its	-PRON-	PRP$
cord-001293-dfaxj3bv	25	45	capacity	capacity	NN
cord-001293-dfaxj3bv	25	46	to	to	TO
cord-001293-dfaxj3bv	25	47	favor	favor	VB
cord-001293-dfaxj3bv	25	48	the	the	DT
cord-001293-dfaxj3bv	25	49	differentiation	differentiation	NN
cord-001293-dfaxj3bv	25	50	of	of	IN
cord-001293-dfaxj3bv	25	51	T	T	NNP
cord-001293-dfaxj3bv	25	52	helper	helper	NN
cord-001293-dfaxj3bv	25	53	(	(	-LRB-
cord-001293-dfaxj3bv	25	54	Th	Th	NNP
cord-001293-dfaxj3bv	25	55	)	)	-RRB-
cord-001293-dfaxj3bv	25	56	17	17	CD
cord-001293-dfaxj3bv	25	57	and	and	CC
cord-001293-dfaxj3bv	25	58	production	production	NN
cord-001293-dfaxj3bv	25	59	of	of	IN
cord-001293-dfaxj3bv	25	60	the	the	DT
cord-001293-dfaxj3bv	25	61	pro	pro	JJ
cord-001293-dfaxj3bv	25	62	-	-	JJ
cord-001293-dfaxj3bv	25	63	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	25	64	IL-17	IL-17	NNP
cord-001293-dfaxj3bv	25	65	.	.	.
cord-001293-dfaxj3bv	26	1	The	the	DT
cord-001293-dfaxj3bv	26	2	classification	classification	NN
cord-001293-dfaxj3bv	26	3	of	of	IN
cord-001293-dfaxj3bv	26	4	non	non	JJ
cord-001293-dfaxj3bv	26	5	-	-	JJ
cord-001293-dfaxj3bv	26	6	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	26	7	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	26	8	mediators	mediator	NNS
cord-001293-dfaxj3bv	26	9	also	also	RB
cord-001293-dfaxj3bv	26	10	relies	rely	VBZ
cord-001293-dfaxj3bv	26	11	on	on	IN
cord-001293-dfaxj3bv	26	12	an	an	DT
cord-001293-dfaxj3bv	26	13	overly	overly	RB
cord-001293-dfaxj3bv	26	14	simplistic	simplistic	JJ
cord-001293-dfaxj3bv	26	15	division	division	NN
cord-001293-dfaxj3bv	26	16	between	between	IN
cord-001293-dfaxj3bv	26	17	proand	proand	JJ
cord-001293-dfaxj3bv	26	18	anti	anti	JJ
cord-001293-dfaxj3bv	26	19	-	-	JJ
cord-001293-dfaxj3bv	26	20	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	26	21	properties	property	NNS
cord-001293-dfaxj3bv	26	22	.	.	.
cord-001293-dfaxj3bv	27	1	This	this	DT
cord-001293-dfaxj3bv	27	2	is	be	VBZ
cord-001293-dfaxj3bv	27	3	well	well	RB
cord-001293-dfaxj3bv	27	4	illustrated	illustrate	VBN
cord-001293-dfaxj3bv	27	5	by	by	IN
cord-001293-dfaxj3bv	27	6	prostaglandin	prostaglandin	NN
cord-001293-dfaxj3bv	27	7	E	e	NN
cord-001293-dfaxj3bv	27	8	2	2	CD
cord-001293-dfaxj3bv	28	1	(	(	-LRB-
cord-001293-dfaxj3bv	28	2	PGE	PGE	NNP
cord-001293-dfaxj3bv	28	3	2	2	CD
cord-001293-dfaxj3bv	28	4	)	)	-RRB-
cord-001293-dfaxj3bv	28	5	,	,	,
cord-001293-dfaxj3bv	28	6	a	a	DT
cord-001293-dfaxj3bv	28	7	key	key	JJ
cord-001293-dfaxj3bv	28	8	mediator	mediator	NN
cord-001293-dfaxj3bv	28	9	of	of	IN
cord-001293-dfaxj3bv	28	10	infectious	infectious	JJ
cord-001293-dfaxj3bv	28	11	immunopathology	immunopathology	NN
cord-001293-dfaxj3bv	28	12	.	.	.
cord-001293-dfaxj3bv	29	1	On	on	IN
cord-001293-dfaxj3bv	29	2	one	one	CD
cord-001293-dfaxj3bv	29	3	hand	hand	NN
cord-001293-dfaxj3bv	29	4	,	,	,
cord-001293-dfaxj3bv	29	5	PGE	PGE	NNP
cord-001293-dfaxj3bv	29	6	2	2	CD
cord-001293-dfaxj3bv	29	7	induces	induce	VBZ
cord-001293-dfaxj3bv	29	8	fever	fever	NN
cord-001293-dfaxj3bv	29	9	,	,	,
cord-001293-dfaxj3bv	29	10	increases	increase	VBZ
cord-001293-dfaxj3bv	29	11	vascular	vascular	JJ
cord-001293-dfaxj3bv	29	12	permeability	permeability	NN
cord-001293-dfaxj3bv	29	13	,	,	,
cord-001293-dfaxj3bv	29	14	increases	increase	VBZ
cord-001293-dfaxj3bv	29	15	vasodilatation	vasodilatation	NN
cord-001293-dfaxj3bv	29	16	,	,	,
cord-001293-dfaxj3bv	29	17	and	and	CC
cord-001293-dfaxj3bv	29	18	causes	cause	VBZ
cord-001293-dfaxj3bv	29	19	pain	pain	NN
cord-001293-dfaxj3bv	29	20	while	while	IN
cord-001293-dfaxj3bv	29	21	also	also	RB
cord-001293-dfaxj3bv	29	22	inhibiting	inhibit	VBG
cord-001293-dfaxj3bv	29	23	production	production	NN
cord-001293-dfaxj3bv	29	24	of	of	IN
cord-001293-dfaxj3bv	29	25	TNF	TNF	NNP
cord-001293-dfaxj3bv	29	26	,	,	,
cord-001293-dfaxj3bv	29	27	increasing	increase	VBG
cord-001293-dfaxj3bv	29	28	production	production	NN
cord-001293-dfaxj3bv	29	29	of	of	IN
cord-001293-dfaxj3bv	29	30	IL-6	IL-6	NNP
cord-001293-dfaxj3bv	29	31	,	,	,
cord-001293-dfaxj3bv	29	32	inhibiting	inhibit	VBG
cord-001293-dfaxj3bv	29	33	5-lipoxygenase	5-lipoxygenase	CD
cord-001293-dfaxj3bv	29	34	and	and	CC
cord-001293-dfaxj3bv	29	35	leukotriene	leukotriene	NN
cord-001293-dfaxj3bv	29	36	A4	A4	NNP
cord-001293-dfaxj3bv	29	37	generation	generation	NN
cord-001293-dfaxj3bv	29	38	,	,	,
cord-001293-dfaxj3bv	29	39	and	and	CC
cord-001293-dfaxj3bv	29	40	inducing	induce	VBG
cord-001293-dfaxj3bv	29	41	15lipoxygenase	15lipoxygenase	CD
cord-001293-dfaxj3bv	30	1	and	and	CC
cord-001293-dfaxj3bv	30	2	the	the	DT
cord-001293-dfaxj3bv	30	3	generation	generation	NN
cord-001293-dfaxj3bv	30	4	of	of	IN
cord-001293-dfaxj3bv	30	5	the	the	DT
cord-001293-dfaxj3bv	30	6	lipoxins	lipoxin	NNS
cord-001293-dfaxj3bv	30	7	involved	involve	VBN
cord-001293-dfaxj3bv	30	8	in	in	IN
cord-001293-dfaxj3bv	30	9	inflammation	inflammation	NN
cord-001293-dfaxj3bv	30	10	resolution	resolution	NN
cord-001293-dfaxj3bv	30	11	.	.	.
cord-001293-dfaxj3bv	31	1	On	on	IN
cord-001293-dfaxj3bv	31	2	the	the	DT
cord-001293-dfaxj3bv	31	3	other	other	JJ
cord-001293-dfaxj3bv	31	4	hand	hand	NN
cord-001293-dfaxj3bv	31	5	,	,	,
cord-001293-dfaxj3bv	31	6	PGE	PGE	NNP
cord-001293-dfaxj3bv	31	7	2	2	CD
cord-001293-dfaxj3bv	31	8	has	have	VBZ
cord-001293-dfaxj3bv	31	9	inhibitory	inhibitory	JJ
cord-001293-dfaxj3bv	31	10	properties	property	NNS
cord-001293-dfaxj3bv	31	11	on	on	IN
cord-001293-dfaxj3bv	31	12	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	31	13	,	,	,
cord-001293-dfaxj3bv	31	14	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	31	15	,	,	,
cord-001293-dfaxj3bv	31	16	Th1	th1	NN
cord-001293-dfaxj3bv	31	17	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	31	18	,	,	,
cord-001293-dfaxj3bv	31	19	natural	natural	JJ
cord-001293-dfaxj3bv	31	20	killer	killer	NN
cord-001293-dfaxj3bv	31	21	(	(	-LRB-
cord-001293-dfaxj3bv	31	22	NK	NK	NNP
cord-001293-dfaxj3bv	31	23	)	)	-RRB-
cord-001293-dfaxj3bv	31	24	cells	cell	NNS
cord-001293-dfaxj3bv	31	25	,	,	,
cord-001293-dfaxj3bv	31	26	and	and	CC
cord-001293-dfaxj3bv	31	27	cytotoxic	cytotoxic	JJ
cord-001293-dfaxj3bv	31	28	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	31	29	but	but	CC
cord-001293-dfaxj3bv	31	30	activates	activate	VBZ
cord-001293-dfaxj3bv	31	31	mast	mast	NN
cord-001293-dfaxj3bv	31	32	cells	cell	NNS
cord-001293-dfaxj3bv	31	33	,	,	,
cord-001293-dfaxj3bv	31	34	Th2	Th2	NNP
cord-001293-dfaxj3bv	31	35	,	,	,
cord-001293-dfaxj3bv	31	36	Th17	Th17	NNP
cord-001293-dfaxj3bv	31	37	,	,	,
cord-001293-dfaxj3bv	31	38	and	and	CC
cord-001293-dfaxj3bv	31	39	regulatory	regulatory	JJ
cord-001293-dfaxj3bv	31	40	T	t	NN
cord-001293-dfaxj3bv	31	41	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	31	42	(	(	-LRB-
cord-001293-dfaxj3bv	31	43	T	T	NNP
cord-001293-dfaxj3bv	31	44	reg	reg	NNP
cord-001293-dfaxj3bv	31	45	)	)	-RRB-
cord-001293-dfaxj3bv	31	46	[	[	-LRB-
cord-001293-dfaxj3bv	31	47	10	10	CD
cord-001293-dfaxj3bv	31	48	]	]	-RRB-
cord-001293-dfaxj3bv	31	49	.	.	.
cord-001293-dfaxj3bv	32	1	This	this	DT
cord-001293-dfaxj3bv	32	2	panoply	panoply	NN
cord-001293-dfaxj3bv	32	3	of	of	IN
cord-001293-dfaxj3bv	32	4	PGE	PGE	NNP
cord-001293-dfaxj3bv	32	5	2	2	CD
cord-001293-dfaxj3bv	33	1	-stimulated	-stimulated	JJ
cord-001293-dfaxj3bv	33	2	events	event	NNS
cord-001293-dfaxj3bv	33	3	amply	amply	RB
cord-001293-dfaxj3bv	33	4	demonstrates	demonstrate	VBZ
cord-001293-dfaxj3bv	33	5	the	the	DT
cord-001293-dfaxj3bv	33	6	inability	inability	NN
cord-001293-dfaxj3bv	33	7	to	to	TO
cord-001293-dfaxj3bv	33	8	simply	simply	RB
cord-001293-dfaxj3bv	33	9	characterize	characterize	VB
cord-001293-dfaxj3bv	33	10	the	the	DT
cord-001293-dfaxj3bv	33	11	activities	activity	NNS
cord-001293-dfaxj3bv	33	12	of	of	IN
cord-001293-dfaxj3bv	33	13	this	this	DT
cord-001293-dfaxj3bv	33	14	and	and	CC
cord-001293-dfaxj3bv	33	15	the	the	DT
cord-001293-dfaxj3bv	33	16	other	other	JJ
cord-001293-dfaxj3bv	33	17	molecules	molecule	NNS
cord-001293-dfaxj3bv	33	18	mentioned	mention	VBN
cord-001293-dfaxj3bv	33	19	as	as	IN
cord-001293-dfaxj3bv	33	20	pro	pro	JJ
cord-001293-dfaxj3bv	33	21	-	-	JJ
cord-001293-dfaxj3bv	33	22	or	or	CC
cord-001293-dfaxj3bv	33	23	anti	anti	JJ
cord-001293-dfaxj3bv	33	24	-	-	JJ
cord-001293-dfaxj3bv	33	25	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	33	26	.	.	.
cord-001293-dfaxj3bv	34	1	In	in	IN
cord-001293-dfaxj3bv	34	2	an	an	DT
cord-001293-dfaxj3bv	34	3	early	early	JJ
cord-001293-dfaxj3bv	34	4	anti	anti	JJ
cord-001293-dfaxj3bv	34	5	-	-	JJ
cord-001293-dfaxj3bv	34	6	TNF	tnf	JJ
cord-001293-dfaxj3bv	34	7	monoclonal	monoclonal	JJ
cord-001293-dfaxj3bv	34	8	antibody	antibody	NN
cord-001293-dfaxj3bv	34	9	intervention	intervention	NN
cord-001293-dfaxj3bv	34	10	study	study	NN
cord-001293-dfaxj3bv	34	11	,	,	,
cord-001293-dfaxj3bv	34	12	a	a	DT
cord-001293-dfaxj3bv	34	13	significant	significant	JJ
cord-001293-dfaxj3bv	34	14	improvement	improvement	NN
cord-001293-dfaxj3bv	34	15	in	in	IN
cord-001293-dfaxj3bv	34	16	day	day	NN
cord-001293-dfaxj3bv	34	17	3	3	CD
cord-001293-dfaxj3bv	34	18	survival	survival	NN
cord-001293-dfaxj3bv	34	19	was	be	VBD
cord-001293-dfaxj3bv	34	20	observed	observe	VBN
cord-001293-dfaxj3bv	34	21	between	between	IN
cord-001293-dfaxj3bv	34	22	the	the	DT
cord-001293-dfaxj3bv	34	23	antibody	antibody	NN
cord-001293-dfaxj3bv	34	24	-	-	HYPH
cord-001293-dfaxj3bv	34	25	treated	treat	VBN
cord-001293-dfaxj3bv	34	26	group	group	NN
cord-001293-dfaxj3bv	34	27	and	and	CC
cord-001293-dfaxj3bv	34	28	the	the	DT
cord-001293-dfaxj3bv	34	29	placebo	placebo	NN
cord-001293-dfaxj3bv	34	30	group	group	NN
cord-001293-dfaxj3bv	34	31	[	[	-LRB-
cord-001293-dfaxj3bv	34	32	11	11	CD
cord-001293-dfaxj3bv	34	33	]	]	-RRB-
cord-001293-dfaxj3bv	34	34	.	.	.
cord-001293-dfaxj3bv	35	1	Although	although	IN
cord-001293-dfaxj3bv	35	2	this	this	DT
cord-001293-dfaxj3bv	35	3	was	be	VBD
cord-001293-dfaxj3bv	35	4	not	not	RB
cord-001293-dfaxj3bv	35	5	a	a	DT
cord-001293-dfaxj3bv	35	6	prespecified	prespecified	JJ
cord-001293-dfaxj3bv	35	7	primary	primary	JJ
cord-001293-dfaxj3bv	35	8	outcome	outcome	NN
cord-001293-dfaxj3bv	35	9	,	,	,
cord-001293-dfaxj3bv	35	10	it	-PRON-	PRP
cord-001293-dfaxj3bv	35	11	is	be	VBZ
cord-001293-dfaxj3bv	35	12	interesting	interesting	JJ
cord-001293-dfaxj3bv	35	13	to	to	TO
cord-001293-dfaxj3bv	35	14	see	see	VB
cord-001293-dfaxj3bv	35	15	that	that	IN
cord-001293-dfaxj3bv	35	16	the	the	DT
cord-001293-dfaxj3bv	35	17	treatment	treatment	NN
cord-001293-dfaxj3bv	35	18	targeting	target	VBG
cord-001293-dfaxj3bv	35	19	TNF	TNF	NNP
cord-001293-dfaxj3bv	35	20	consisting	consist	VBG
cord-001293-dfaxj3bv	35	21	of	of	IN
cord-001293-dfaxj3bv	35	22	a	a	DT
cord-001293-dfaxj3bv	35	23	single	single	JJ
cord-001293-dfaxj3bv	35	24	early	early	JJ
cord-001293-dfaxj3bv	35	25	injection	injection	NN
cord-001293-dfaxj3bv	35	26	was	be	VBD
cord-001293-dfaxj3bv	35	27	beneficial	beneficial	JJ
cord-001293-dfaxj3bv	35	28	within	within	IN
cord-001293-dfaxj3bv	35	29	a	a	DT
cord-001293-dfaxj3bv	35	30	short	short	JJ
cord-001293-dfaxj3bv	35	31	period	period	NN
cord-001293-dfaxj3bv	35	32	of	of	IN
cord-001293-dfaxj3bv	35	33	time	time	NN
cord-001293-dfaxj3bv	35	34	after	after	IN
cord-001293-dfaxj3bv	35	35	sepsis	sepsis	NN
cord-001293-dfaxj3bv	35	36	onset	onset	NN
cord-001293-dfaxj3bv	35	37	,	,	,
cord-001293-dfaxj3bv	35	38	reinforcing	reinforce	VBG
cord-001293-dfaxj3bv	35	39	the	the	DT
cord-001293-dfaxj3bv	35	40	idea	idea	NN
cord-001293-dfaxj3bv	35	41	that	that	IN
cord-001293-dfaxj3bv	35	42	TNF	TNF	NNP
cord-001293-dfaxj3bv	35	43	plays	play	VBZ
cord-001293-dfaxj3bv	35	44	a	a	DT
cord-001293-dfaxj3bv	35	45	key	key	JJ
cord-001293-dfaxj3bv	35	46	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	35	47	role	role	NN
cord-001293-dfaxj3bv	35	48	in	in	IN
cord-001293-dfaxj3bv	35	49	the	the	DT
cord-001293-dfaxj3bv	35	50	early	early	JJ
cord-001293-dfaxj3bv	35	51	events	event	NNS
cord-001293-dfaxj3bv	35	52	of	of	IN
cord-001293-dfaxj3bv	35	53	sepsis	sepsis	NN
cord-001293-dfaxj3bv	35	54	.	.	.
cord-001293-dfaxj3bv	36	1	Once	once	IN
cord-001293-dfaxj3bv	36	2	anti	anti	JJ
cord-001293-dfaxj3bv	36	3	-	-	JJ
cord-001293-dfaxj3bv	36	4	TNF	tnf	JJ
cord-001293-dfaxj3bv	36	5	treatments	treatment	NNS
cord-001293-dfaxj3bv	36	6	were	be	VBD
cord-001293-dfaxj3bv	36	7	better	well	RBR
cord-001293-dfaxj3bv	36	8	targeted	target	VBN
cord-001293-dfaxj3bv	36	9	to	to	IN
cord-001293-dfaxj3bv	36	10	the	the	DT
cord-001293-dfaxj3bv	36	11	sickest	sick	JJS
cord-001293-dfaxj3bv	36	12	patients	patient	NNS
cord-001293-dfaxj3bv	36	13	by	by	IN
cord-001293-dfaxj3bv	36	14	adding	add	VBG
cord-001293-dfaxj3bv	36	15	biological	biological	JJ
cord-001293-dfaxj3bv	36	16	inclusion	inclusion	NN
cord-001293-dfaxj3bv	36	17	parameters	parameter	NNS
cord-001293-dfaxj3bv	36	18	(	(	-LRB-
cord-001293-dfaxj3bv	36	19	plasma	plasma	NN
cord-001293-dfaxj3bv	36	20	IL-6	IL-6	NNP
cord-001293-dfaxj3bv	36	21	level	level	NN
cord-001293-dfaxj3bv	36	22	)	)	-RRB-
cord-001293-dfaxj3bv	36	23	,	,	,
cord-001293-dfaxj3bv	36	24	survival	survival	NN
cord-001293-dfaxj3bv	36	25	was	be	VBD
cord-001293-dfaxj3bv	36	26	significantly	significantly	RB
cord-001293-dfaxj3bv	36	27	improved	improve	VBN
cord-001293-dfaxj3bv	36	28	on	on	IN
cord-001293-dfaxj3bv	36	29	day	day	NN
cord-001293-dfaxj3bv	36	30	28	28	CD
cord-001293-dfaxj3bv	36	31	[	[	-LRB-
cord-001293-dfaxj3bv	36	32	12	12	CD
cord-001293-dfaxj3bv	36	33	]	]	-RRB-
cord-001293-dfaxj3bv	36	34	.	.	.
cord-001293-dfaxj3bv	37	1	Synergistic	synergistic	JJ
cord-001293-dfaxj3bv	37	2	effects	effect	NNS
cord-001293-dfaxj3bv	37	3	between	between	IN
cord-001293-dfaxj3bv	37	4	immune	immune	JJ
cord-001293-dfaxj3bv	37	5	modulators	modulator	NNS
cord-001293-dfaxj3bv	37	6	are	be	VBP
cord-001293-dfaxj3bv	37	7	a	a	DT
cord-001293-dfaxj3bv	37	8	key	key	JJ
cord-001293-dfaxj3bv	37	9	characteristic	characteristic	NN
cord-001293-dfaxj3bv	37	10	of	of	IN
cord-001293-dfaxj3bv	37	11	their	-PRON-	PRP$
cord-001293-dfaxj3bv	37	12	effect	effect	NN
cord-001293-dfaxj3bv	37	13	.	.	.
cord-001293-dfaxj3bv	38	1	This	this	DT
cord-001293-dfaxj3bv	38	2	explains	explain	VBZ
cord-001293-dfaxj3bv	38	3	how	how	WRB
cord-001293-dfaxj3bv	38	4	a	a	DT
cord-001293-dfaxj3bv	38	5	non	non	JJ
cord-001293-dfaxj3bv	38	6	-	-	JJ
cord-001293-dfaxj3bv	38	7	lethal	lethal	JJ
cord-001293-dfaxj3bv	38	8	dose	dose	NN
cord-001293-dfaxj3bv	38	9	of	of	IN
cord-001293-dfaxj3bv	38	10	one	one	CD
cord-001293-dfaxj3bv	38	11	cytokine	cytokine	NN
cord-001293-dfaxj3bv	38	12	can	can	MD
cord-001293-dfaxj3bv	38	13	lead	lead	VB
cord-001293-dfaxj3bv	38	14	to	to	IN
cord-001293-dfaxj3bv	38	15	mortality	mortality	NN
cord-001293-dfaxj3bv	38	16	when	when	WRB
cord-001293-dfaxj3bv	38	17	injected	inject	VBN
cord-001293-dfaxj3bv	38	18	with	with	IN
cord-001293-dfaxj3bv	38	19	a	a	DT
cord-001293-dfaxj3bv	38	20	non	non	JJ
cord-001293-dfaxj3bv	38	21	-	-	JJ
cord-001293-dfaxj3bv	38	22	lethal	lethal	JJ
cord-001293-dfaxj3bv	38	23	dose	dose	NN
cord-001293-dfaxj3bv	38	24	of	of	IN
cord-001293-dfaxj3bv	38	25	another	another	DT
cord-001293-dfaxj3bv	38	26	cytokine	cytokine	NN
cord-001293-dfaxj3bv	38	27	.	.	.
cord-001293-dfaxj3bv	39	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	39	2	,	,	,
cord-001293-dfaxj3bv	39	3	it	-PRON-	PRP
cord-001293-dfaxj3bv	39	4	may	may	MD
cord-001293-dfaxj3bv	39	5	explain	explain	VB
cord-001293-dfaxj3bv	39	6	how	how	WRB
cord-001293-dfaxj3bv	39	7	the	the	DT
cord-001293-dfaxj3bv	39	8	removal	removal	NN
cord-001293-dfaxj3bv	39	9	of	of	IN
cord-001293-dfaxj3bv	39	10	some	some	DT
cord-001293-dfaxj3bv	39	11	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	39	12	mediators	mediator	NNS
cord-001293-dfaxj3bv	39	13	by	by	IN
cord-001293-dfaxj3bv	39	14	coupled	coupled	JJ
cord-001293-dfaxj3bv	39	15	plasma	plasma	NN
cord-001293-dfaxj3bv	39	16	filtrationadsorption	filtrationadsorption	NN
cord-001293-dfaxj3bv	39	17	was	be	VBD
cord-001293-dfaxj3bv	39	18	protective	protective	JJ
cord-001293-dfaxj3bv	39	19	in	in	IN
cord-001293-dfaxj3bv	39	20	an	an	DT
cord-001293-dfaxj3bv	39	21	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	39	22	-	-	HYPH
cord-001293-dfaxj3bv	39	23	shock	shock	NN
cord-001293-dfaxj3bv	39	24	model	model	NN
cord-001293-dfaxj3bv	39	25	while	while	IN
cord-001293-dfaxj3bv	39	26	levels	level	NNS
cord-001293-dfaxj3bv	39	27	of	of	IN
cord-001293-dfaxj3bv	39	28	circulating	circulate	VBG
cord-001293-dfaxj3bv	39	29	bio	bio	JJ
cord-001293-dfaxj3bv	39	30	-	-	HYPH
cord-001293-dfaxj3bv	39	31	active	active	JJ
cord-001293-dfaxj3bv	39	32	TNF	TNF	NNP
cord-001293-dfaxj3bv	39	33	were	be	VBD
cord-001293-dfaxj3bv	39	34	unaffected	unaffected	JJ
cord-001293-dfaxj3bv	39	35	[	[	-LRB-
cord-001293-dfaxj3bv	39	36	13	13	CD
cord-001293-dfaxj3bv	39	37	]	]	-RRB-
cord-001293-dfaxj3bv	39	38	.	.	.
cord-001293-dfaxj3bv	40	1	Clear	clear	JJ
cord-001293-dfaxj3bv	40	2	demonstrations	demonstration	NNS
cord-001293-dfaxj3bv	40	3	of	of	IN
cord-001293-dfaxj3bv	40	4	cytokine	cytokine	NN
cord-001293-dfaxj3bv	40	5	-	-	HYPH
cord-001293-dfaxj3bv	40	6	mediated	mediate	VBN
cord-001293-dfaxj3bv	40	7	tissue	tissue	NN
cord-001293-dfaxj3bv	40	8	damage	damage	NN
cord-001293-dfaxj3bv	40	9	exist	exist	VBP
cord-001293-dfaxj3bv	40	10	.	.	.
cord-001293-dfaxj3bv	41	1	Nevertheless	nevertheless	RB
cord-001293-dfaxj3bv	41	2	,	,	,
cord-001293-dfaxj3bv	41	3	because	because	IN
cord-001293-dfaxj3bv	41	4	of	of	IN
cord-001293-dfaxj3bv	41	5	their	-PRON-	PRP$
cord-001293-dfaxj3bv	41	6	ambiguous	ambiguous	JJ
cord-001293-dfaxj3bv	41	7	role	role	NN
cord-001293-dfaxj3bv	41	8	mentioned	mention	VBN
cord-001293-dfaxj3bv	41	9	above	above	RB
cord-001293-dfaxj3bv	41	10	,	,	,
cord-001293-dfaxj3bv	41	11	identification	identification	NN
cord-001293-dfaxj3bv	41	12	of	of	IN
cord-001293-dfaxj3bv	41	13	their	-PRON-	PRP$
cord-001293-dfaxj3bv	41	14	precise	precise	JJ
cord-001293-dfaxj3bv	41	15	role	role	NN
cord-001293-dfaxj3bv	41	16	during	during	IN
cord-001293-dfaxj3bv	41	17	sepsis	sepsis	NN
cord-001293-dfaxj3bv	41	18	has	have	VBZ
cord-001293-dfaxj3bv	41	19	led	lead	VBN
cord-001293-dfaxj3bv	41	20	to	to	IN
cord-001293-dfaxj3bv	41	21	controversy	controversy	NN
cord-001293-dfaxj3bv	41	22	.	.	.
cord-001293-dfaxj3bv	42	1	In	in	IN
cord-001293-dfaxj3bv	42	2	animal	animal	NN
cord-001293-dfaxj3bv	42	3	models	model	NNS
cord-001293-dfaxj3bv	42	4	of	of	IN
cord-001293-dfaxj3bv	42	5	sepsis	sepsis	NN
cord-001293-dfaxj3bv	42	6	,	,	,
cord-001293-dfaxj3bv	42	7	the	the	DT
cord-001293-dfaxj3bv	42	8	role	role	NN
cord-001293-dfaxj3bv	42	9	of	of	IN
cord-001293-dfaxj3bv	42	10	TNF	TNF	NNP
cord-001293-dfaxj3bv	42	11	may	may	MD
cord-001293-dfaxj3bv	42	12	vary	vary	VB
cord-001293-dfaxj3bv	42	13	depending	depend	VBG
cord-001293-dfaxj3bv	42	14	upon	upon	IN
cord-001293-dfaxj3bv	42	15	the	the	DT
cord-001293-dfaxj3bv	42	16	type	type	NN
cord-001293-dfaxj3bv	42	17	of	of	IN
cord-001293-dfaxj3bv	42	18	infection	infection	NN
cord-001293-dfaxj3bv	42	19	[	[	-LRB-
cord-001293-dfaxj3bv	42	20	14	14	CD
cord-001293-dfaxj3bv	42	21	]	]	-RRB-
cord-001293-dfaxj3bv	42	22	.	.	.
cord-001293-dfaxj3bv	43	1	Many	many	JJ
cord-001293-dfaxj3bv	43	2	model	model	NN
cord-001293-dfaxj3bv	43	3	parameters	parameter	NNS
cord-001293-dfaxj3bv	43	4	influence	influence	VBP
cord-001293-dfaxj3bv	43	5	conclusions	conclusion	NNS
cord-001293-dfaxj3bv	43	6	of	of	IN
cord-001293-dfaxj3bv	43	7	the	the	DT
cord-001293-dfaxj3bv	43	8	relative	relative	JJ
cord-001293-dfaxj3bv	43	9	role	role	NN
cord-001293-dfaxj3bv	43	10	of	of	IN
cord-001293-dfaxj3bv	43	11	the	the	DT
cord-001293-dfaxj3bv	43	12	different	different	JJ
cord-001293-dfaxj3bv	43	13	mediators	mediator	NNS
cord-001293-dfaxj3bv	43	14	studied	study	VBD
cord-001293-dfaxj3bv	43	15	.	.	.
cord-001293-dfaxj3bv	44	1	Identical	identical	JJ
cord-001293-dfaxj3bv	44	2	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	44	3	have	have	VBP
cord-001293-dfaxj3bv	44	4	been	be	VBN
cord-001293-dfaxj3bv	44	5	found	find	VBN
cord-001293-dfaxj3bv	44	6	to	to	TO
cord-001293-dfaxj3bv	44	7	be	be	VB
cord-001293-dfaxj3bv	44	8	protective	protective	JJ
cord-001293-dfaxj3bv	44	9	or	or	CC
cord-001293-dfaxj3bv	44	10	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	44	11	depending	depending	NN
cord-001293-dfaxj3bv	44	12	upon	upon	IN
cord-001293-dfaxj3bv	44	13	the	the	DT
cord-001293-dfaxj3bv	44	14	model	model	NN
cord-001293-dfaxj3bv	44	15	.	.	.
cord-001293-dfaxj3bv	45	1	This	this	DT
cord-001293-dfaxj3bv	45	2	has	have	VBZ
cord-001293-dfaxj3bv	45	3	been	be	VBN
cord-001293-dfaxj3bv	45	4	the	the	DT
cord-001293-dfaxj3bv	45	5	case	case	NN
cord-001293-dfaxj3bv	45	6	for	for	IN
cord-001293-dfaxj3bv	45	7	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	45	8	[	[	-LRB-
cord-001293-dfaxj3bv	45	9	15	15	CD
cord-001293-dfaxj3bv	45	10	]	]	-RRB-
cord-001293-dfaxj3bv	45	11	and	and	CC
cord-001293-dfaxj3bv	45	12	granulocytemacrophage	granulocytemacrophage	``
cord-001293-dfaxj3bv	45	13	colony	colony	NN
cord-001293-dfaxj3bv	45	14	-	-	HYPH
cord-001293-dfaxj3bv	45	15	stimulating	stimulate	VBG
cord-001293-dfaxj3bv	45	16	factor	factor	NN
cord-001293-dfaxj3bv	45	17	(	(	-LRB-
cord-001293-dfaxj3bv	45	18	GM	GM	NNP
cord-001293-dfaxj3bv	45	19	-	-	HYPH
cord-001293-dfaxj3bv	45	20	CSF	CSF	NNP
cord-001293-dfaxj3bv	45	21	)	)	-RRB-
cord-001293-dfaxj3bv	45	22	[	[	-LRB-
cord-001293-dfaxj3bv	45	23	16	16	CD
cord-001293-dfaxj3bv	45	24	]	]	-RRB-
cord-001293-dfaxj3bv	45	25	among	among	IN
cord-001293-dfaxj3bv	45	26	others	other	NNS
cord-001293-dfaxj3bv	45	27	(	(	-LRB-
cord-001293-dfaxj3bv	45	28	for	for	IN
cord-001293-dfaxj3bv	45	29	example	example	NN
cord-001293-dfaxj3bv	45	30	,	,	,
cord-001293-dfaxj3bv	45	31	IL-17	IL-17	NNP
cord-001293-dfaxj3bv	45	32	,	,	,
cord-001293-dfaxj3bv	45	33	IL-33	IL-33	NNP
cord-001293-dfaxj3bv	45	34	,	,	,
cord-001293-dfaxj3bv	45	35	'	'	''
cord-001293-dfaxj3bv	45	36	TNF	tnf	NN
cord-001293-dfaxj3bv	45	37	-	-	HYPH
cord-001293-dfaxj3bv	45	38	related	relate	VBN
cord-001293-dfaxj3bv	45	39	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	45	40	-	-	HYPH
cord-001293-dfaxj3bv	45	41	inducing	induce	VBG
cord-001293-dfaxj3bv	45	42	ligand	ligand	NN
cord-001293-dfaxj3bv	45	43	'	'	''
cord-001293-dfaxj3bv	45	44	(	(	-LRB-
cord-001293-dfaxj3bv	45	45	TRAIL	TRAIL	NNP
cord-001293-dfaxj3bv	45	46	)	)	-RRB-
cord-001293-dfaxj3bv	45	47	,	,	,
cord-001293-dfaxj3bv	45	48	and	and	CC
cord-001293-dfaxj3bv	45	49	TGFβ	TGFβ	NNP
cord-001293-dfaxj3bv	45	50	)	)	-RRB-
cord-001293-dfaxj3bv	45	51	.	.	.
cord-001293-dfaxj3bv	46	1	Host	host	NN
cord-001293-dfaxj3bv	46	2	-	-	HYPH
cord-001293-dfaxj3bv	46	3	protective	protective	JJ
cord-001293-dfaxj3bv	46	4	innate	innate	JJ
cord-001293-dfaxj3bv	46	5	immune	immune	JJ
cord-001293-dfaxj3bv	46	6	responses	response	NNS
cord-001293-dfaxj3bv	46	7	and	and	CC
cord-001293-dfaxj3bv	46	8	consequent	consequent	JJ
cord-001293-dfaxj3bv	46	9	inflammation	inflammation	NN
cord-001293-dfaxj3bv	46	10	are	be	VBP
cord-001293-dfaxj3bv	46	11	inextricably	inextricably	RB
cord-001293-dfaxj3bv	46	12	linked	link	VBN
cord-001293-dfaxj3bv	46	13	and	and	CC
cord-001293-dfaxj3bv	46	14	overlapping	overlapping	NN
cord-001293-dfaxj3bv	46	15	.	.	.
cord-001293-dfaxj3bv	47	1	Consequently	consequently	RB
cord-001293-dfaxj3bv	47	2	,	,	,
cord-001293-dfaxj3bv	47	3	the	the	DT
cord-001293-dfaxj3bv	47	4	same	same	JJ
cord-001293-dfaxj3bv	47	5	cellular	cellular	JJ
cord-001293-dfaxj3bv	47	6	actors	actor	NNS
cord-001293-dfaxj3bv	47	7	are	be	VBP
cord-001293-dfaxj3bv	47	8	key	key	JJ
cord-001293-dfaxj3bv	47	9	elements	element	NNS
cord-001293-dfaxj3bv	47	10	defending	defend	VBG
cord-001293-dfaxj3bv	47	11	the	the	DT
cord-001293-dfaxj3bv	47	12	host	host	NN
cord-001293-dfaxj3bv	47	13	against	against	IN
cord-001293-dfaxj3bv	47	14	infection	infection	NN
cord-001293-dfaxj3bv	47	15	while	while	IN
cord-001293-dfaxj3bv	47	16	simultaneously	simultaneously	RB
cord-001293-dfaxj3bv	47	17	contributing	contribute	VBG
cord-001293-dfaxj3bv	47	18	to	to	IN
cord-001293-dfaxj3bv	47	19	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	47	20	events	event	NNS
cord-001293-dfaxj3bv	47	21	.	.	.
cord-001293-dfaxj3bv	48	1	For	for	IN
cord-001293-dfaxj3bv	48	2	example	example	NN
cord-001293-dfaxj3bv	48	3	,	,	,
cord-001293-dfaxj3bv	48	4	neutrophil	neutrophil	NN
cord-001293-dfaxj3bv	48	5	extracellular	extracellular	JJ
cord-001293-dfaxj3bv	48	6	traps	trap	NNS
cord-001293-dfaxj3bv	48	7	that	that	WDT
cord-001293-dfaxj3bv	48	8	catch	catch	VBP
cord-001293-dfaxj3bv	48	9	and	and	CC
cord-001293-dfaxj3bv	48	10	kill	kill	VB
cord-001293-dfaxj3bv	48	11	bacteria	bacteria	NNS
cord-001293-dfaxj3bv	48	12	and	and	CC
cord-001293-dfaxj3bv	48	13	fungi	fungus	NNS
cord-001293-dfaxj3bv	48	14	are	be	VBP
cord-001293-dfaxj3bv	48	15	associated	associate	VBN
cord-001293-dfaxj3bv	48	16	with	with	IN
cord-001293-dfaxj3bv	48	17	the	the	DT
cord-001293-dfaxj3bv	48	18	release	release	NN
cord-001293-dfaxj3bv	48	19	of	of	IN
cord-001293-dfaxj3bv	48	20	elements	element	NNS
cord-001293-dfaxj3bv	48	21	such	such	JJ
cord-001293-dfaxj3bv	48	22	as	as	IN
cord-001293-dfaxj3bv	48	23	histones	histone	NNS
cord-001293-dfaxj3bv	48	24	and	and	CC
cord-001293-dfaxj3bv	48	25	mitochondria	mitochondrion	NNS
cord-001293-dfaxj3bv	48	26	that	that	WDT
cord-001293-dfaxj3bv	48	27	behave	behave	VBP
cord-001293-dfaxj3bv	48	28	like	like	IN
cord-001293-dfaxj3bv	48	29	damage	damage	NN
cord-001293-dfaxj3bv	48	30	-	-	HYPH
cord-001293-dfaxj3bv	48	31	associated	associate	VBN
cord-001293-dfaxj3bv	48	32	molecular	molecular	JJ
cord-001293-dfaxj3bv	48	33	patterns	pattern	NNS
cord-001293-dfaxj3bv	48	34	perpetuating	perpetuate	VBG
cord-001293-dfaxj3bv	48	35	the	the	DT
cord-001293-dfaxj3bv	48	36	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	48	37	process	process	NN
cord-001293-dfaxj3bv	48	38	.	.	.
cord-001293-dfaxj3bv	49	1	Beneficial	beneficial	JJ
cord-001293-dfaxj3bv	49	2	or	or	CC
cord-001293-dfaxj3bv	49	3	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	49	4	roles	role	NNS
cord-001293-dfaxj3bv	49	5	of	of	IN
cord-001293-dfaxj3bv	49	6	the	the	DT
cord-001293-dfaxj3bv	49	7	same	same	JJ
cord-001293-dfaxj3bv	49	8	leukocyte	leukocyte	NN
cord-001293-dfaxj3bv	49	9	subset	subset	VBN
cord-001293-dfaxj3bv	49	10	have	have	VBP
cord-001293-dfaxj3bv	49	11	been	be	VBN
cord-001293-dfaxj3bv	49	12	reported	report	VBN
cord-001293-dfaxj3bv	49	13	depending	depend	VBG
cord-001293-dfaxj3bv	49	14	upon	upon	IN
cord-001293-dfaxj3bv	49	15	the	the	DT
cord-001293-dfaxj3bv	49	16	experimental	experimental	JJ
cord-001293-dfaxj3bv	49	17	model	model	NN
cord-001293-dfaxj3bv	49	18	.	.	.
cord-001293-dfaxj3bv	50	1	For	for	IN
cord-001293-dfaxj3bv	50	2	example	example	NN
cord-001293-dfaxj3bv	50	3	,	,	,
cord-001293-dfaxj3bv	50	4	a	a	DT
cord-001293-dfaxj3bv	50	5	peritonitis	peritonitis	NN
cord-001293-dfaxj3bv	50	6	model	model	NN
cord-001293-dfaxj3bv	50	7	using	use	VBG
cord-001293-dfaxj3bv	50	8	nude	nude	JJ
cord-001293-dfaxj3bv	50	9	mice	mouse	NNS
cord-001293-dfaxj3bv	50	10	(	(	-LRB-
cord-001293-dfaxj3bv	50	11	lacking	lack	VBG
cord-001293-dfaxj3bv	50	12	T	t	NN
cord-001293-dfaxj3bv	50	13	cells	cell	NNS
cord-001293-dfaxj3bv	50	14	)	)	-RRB-
cord-001293-dfaxj3bv	50	15	suggested	suggest	VBD
cord-001293-dfaxj3bv	50	16	that	that	IN
cord-001293-dfaxj3bv	50	17	T	t	NN
cord-001293-dfaxj3bv	50	18	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	50	19	contribute	contribute	VBP
cord-001293-dfaxj3bv	50	20	to	to	IN
cord-001293-dfaxj3bv	50	21	protective	protective	JJ
cord-001293-dfaxj3bv	50	22	immune	immune	JJ
cord-001293-dfaxj3bv	50	23	responses	response	NNS
cord-001293-dfaxj3bv	50	24	[	[	-LRB-
cord-001293-dfaxj3bv	50	25	17	17	CD
cord-001293-dfaxj3bv	50	26	]	]	-RRB-
cord-001293-dfaxj3bv	50	27	.	.	.
cord-001293-dfaxj3bv	51	1	By	by	IN
cord-001293-dfaxj3bv	51	2	contrast	contrast	NN
cord-001293-dfaxj3bv	51	3	,	,	,
cord-001293-dfaxj3bv	51	4	in	in	IN
cord-001293-dfaxj3bv	51	5	an	an	DT
cord-001293-dfaxj3bv	51	6	Escherichia	Escherichia	NNP
cord-001293-dfaxj3bv	51	7	coli	coli	NNS
cord-001293-dfaxj3bv	51	8	sepsis	sepsis	NN
cord-001293-dfaxj3bv	51	9	murine	murine	JJ
cord-001293-dfaxj3bv	51	10	model	model	NN
cord-001293-dfaxj3bv	51	11	,	,	,
cord-001293-dfaxj3bv	51	12	T	t	NN
cord-001293-dfaxj3bv	51	13	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	51	14	markedly	markedly	RB
cord-001293-dfaxj3bv	51	15	contributed	contribute	VBD
cord-001293-dfaxj3bv	51	16	to	to	IN
cord-001293-dfaxj3bv	51	17	severity	severity	NN
cord-001293-dfaxj3bv	51	18	[	[	-LRB-
cord-001293-dfaxj3bv	51	19	18	18	CD
cord-001293-dfaxj3bv	51	20	]	]	-RRB-
cord-001293-dfaxj3bv	51	21	.	.	.
cord-001293-dfaxj3bv	52	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	52	2	,	,	,
cord-001293-dfaxj3bv	52	3	T	T	NNP
cord-001293-dfaxj3bv	52	4	reg	reg	NN
cord-001293-dfaxj3bv	52	5	improved	improve	VBN
cord-001293-dfaxj3bv	52	6	survival	survival	NN
cord-001293-dfaxj3bv	52	7	in	in	IN
cord-001293-dfaxj3bv	52	8	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	52	9	sepsis	sepsis	NN
cord-001293-dfaxj3bv	52	10	[	[	-LRB-
cord-001293-dfaxj3bv	52	11	19	19	CD
cord-001293-dfaxj3bv	52	12	]	]	-RRB-
cord-001293-dfaxj3bv	52	13	whereas	whereas	RB
cord-001293-dfaxj3bv	52	14	,	,	,
cord-001293-dfaxj3bv	52	15	in	in	IN
cord-001293-dfaxj3bv	52	16	another	another	DT
cord-001293-dfaxj3bv	52	17	report	report	NN
cord-001293-dfaxj3bv	52	18	,	,	,
cord-001293-dfaxj3bv	52	19	reduced	reduce	VBD
cord-001293-dfaxj3bv	52	20	T	t	NN
cord-001293-dfaxj3bv	52	21	reg	reg	NN
cord-001293-dfaxj3bv	52	22	activity	activity	NN
cord-001293-dfaxj3bv	52	23	led	lead	VBD
cord-001293-dfaxj3bv	52	24	to	to	IN
cord-001293-dfaxj3bv	52	25	improved	improve	VBN
cord-001293-dfaxj3bv	52	26	survival	survival	NN
cord-001293-dfaxj3bv	52	27	[	[	-LRB-
cord-001293-dfaxj3bv	52	28	20	20	CD
cord-001293-dfaxj3bv	52	29	]	]	-RRB-
cord-001293-dfaxj3bv	52	30	.	.	.
cord-001293-dfaxj3bv	53	1	The	the	DT
cord-001293-dfaxj3bv	53	2	'	'	``
cord-001293-dfaxj3bv	53	3	half	half	JJ
cord-001293-dfaxj3bv	53	4	angel	angel	NN
cord-001293-dfaxj3bv	53	5	/	/	SYM
cord-001293-dfaxj3bv	53	6	half	half	NN
cord-001293-dfaxj3bv	53	7	devil	devil	NNP
cord-001293-dfaxj3bv	53	8	'	'	''
cord-001293-dfaxj3bv	53	9	role	role	NN
cord-001293-dfaxj3bv	53	10	of	of	IN
cord-001293-dfaxj3bv	53	11	NK	NK	NNP
cord-001293-dfaxj3bv	53	12	cells	cell	NNS
cord-001293-dfaxj3bv	53	13	during	during	IN
cord-001293-dfaxj3bv	53	14	severe	severe	JJ
cord-001293-dfaxj3bv	53	15	infection	infection	NN
cord-001293-dfaxj3bv	53	16	is	be	VBZ
cord-001293-dfaxj3bv	53	17	also	also	RB
cord-001293-dfaxj3bv	53	18	described	describe	VBN
cord-001293-dfaxj3bv	53	19	.	.	.
cord-001293-dfaxj3bv	54	1	NK	NK	NNP
cord-001293-dfaxj3bv	54	2	cells	cell	NNS
cord-001293-dfaxj3bv	54	3	contribute	contribute	VBP
cord-001293-dfaxj3bv	54	4	to	to	IN
cord-001293-dfaxj3bv	54	5	systemic	systemic	JJ
cord-001293-dfaxj3bv	54	6	inflammation	inflammation	NN
cord-001293-dfaxj3bv	54	7	during	during	IN
cord-001293-dfaxj3bv	54	8	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	54	9	sepsis	sepsis	NN
cord-001293-dfaxj3bv	54	10	but	but	CC
cord-001293-dfaxj3bv	54	11	play	play	VB
cord-001293-dfaxj3bv	54	12	a	a	DT
cord-001293-dfaxj3bv	54	13	critical	critical	JJ
cord-001293-dfaxj3bv	54	14	protective	protective	JJ
cord-001293-dfaxj3bv	54	15	role	role	NN
cord-001293-dfaxj3bv	54	16	in	in	IN
cord-001293-dfaxj3bv	54	17	host	host	NN
cord-001293-dfaxj3bv	54	18	defense	defense	NN
cord-001293-dfaxj3bv	54	19	against	against	IN
cord-001293-dfaxj3bv	54	20	Staphylococcus	Staphylococcus	NNP
cord-001293-dfaxj3bv	54	21	aureus	aureus	NN
cord-001293-dfaxj3bv	54	22	lung	lung	NN
cord-001293-dfaxj3bv	54	23	infection	infection	NN
cord-001293-dfaxj3bv	54	24	(	(	-LRB-
cord-001293-dfaxj3bv	54	25	as	as	IN
cord-001293-dfaxj3bv	54	26	reviewed	review	VBN
cord-001293-dfaxj3bv	54	27	in	in	IN
cord-001293-dfaxj3bv	54	28	[	[	-LRB-
cord-001293-dfaxj3bv	54	29	21	21	CD
cord-001293-dfaxj3bv	54	30	]	]	-RRB-
cord-001293-dfaxj3bv	54	31	)	)	-RRB-
cord-001293-dfaxj3bv	54	32	.	.	.
cord-001293-dfaxj3bv	55	1	Although	although	IN
cord-001293-dfaxj3bv	55	2	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	55	3	of	of	IN
cord-001293-dfaxj3bv	55	4	dendritic	dendritic	JJ
cord-001293-dfaxj3bv	55	5	cells	cell	NNS
cord-001293-dfaxj3bv	55	6	(	(	-LRB-
cord-001293-dfaxj3bv	55	7	DCs	DCs	NNP
cord-001293-dfaxj3bv	55	8	)	)	-RRB-
cord-001293-dfaxj3bv	55	9	is	be	VBZ
cord-001293-dfaxj3bv	55	10	particularly	particularly	RB
cord-001293-dfaxj3bv	55	11	increased	increase	VBN
cord-001293-dfaxj3bv	55	12	during	during	IN
cord-001293-dfaxj3bv	55	13	sepsis	sepsis	NN
cord-001293-dfaxj3bv	55	14	,	,	,
cord-001293-dfaxj3bv	55	15	they	-PRON-	PRP
cord-001293-dfaxj3bv	55	16	are	be	VBP
cord-001293-dfaxj3bv	55	17	protective	protective	JJ
cord-001293-dfaxj3bv	55	18	in	in	IN
cord-001293-dfaxj3bv	55	19	murine	murine	JJ
cord-001293-dfaxj3bv	55	20	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	55	21	sepsis	sepsis	NN
cord-001293-dfaxj3bv	55	22	[	[	-LRB-
cord-001293-dfaxj3bv	55	23	22	22	CD
cord-001293-dfaxj3bv	55	24	]	]	-RRB-
cord-001293-dfaxj3bv	55	25	.	.	.
cord-001293-dfaxj3bv	56	1	Transcriptomic	Transcriptomic	NNP
cord-001293-dfaxj3bv	56	2	analysis	analysis	NN
cord-001293-dfaxj3bv	56	3	of	of	IN
cord-001293-dfaxj3bv	56	4	DCs	DCs	NNP
cord-001293-dfaxj3bv	56	5	in	in	IN
cord-001293-dfaxj3bv	56	6	trauma	trauma	NN
cord-001293-dfaxj3bv	56	7	patients	patient	NNS
cord-001293-dfaxj3bv	56	8	shows	show	VBZ
cord-001293-dfaxj3bv	56	9	a	a	DT
cord-001293-dfaxj3bv	56	10	large	large	JJ
cord-001293-dfaxj3bv	56	11	number	number	NN
cord-001293-dfaxj3bv	56	12	of	of	IN
cord-001293-dfaxj3bv	56	13	upregulated	upregulate	VBN
cord-001293-dfaxj3bv	56	14	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	56	15	genes	gene	NNS
cord-001293-dfaxj3bv	56	16	,	,	,
cord-001293-dfaxj3bv	56	17	suggesting	suggest	VBG
cord-001293-dfaxj3bv	56	18	their	-PRON-	PRP$
cord-001293-dfaxj3bv	56	19	contribution	contribution	NN
cord-001293-dfaxj3bv	56	20	to	to	IN
cord-001293-dfaxj3bv	56	21	systemic	systemic	JJ
cord-001293-dfaxj3bv	56	22	inflammation	inflammation	NN
cord-001293-dfaxj3bv	56	23	and	and	CC
cord-001293-dfaxj3bv	56	24	organ	organ	NN
cord-001293-dfaxj3bv	56	25	failure	failure	NN
cord-001293-dfaxj3bv	56	26	[	[	-LRB-
cord-001293-dfaxj3bv	56	27	23	23	CD
cord-001293-dfaxj3bv	56	28	]	]	-RRB-
cord-001293-dfaxj3bv	56	29	.	.	.
cord-001293-dfaxj3bv	57	1	Apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	57	2	of	of	IN
cord-001293-dfaxj3bv	57	3	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	57	4	,	,	,
cord-001293-dfaxj3bv	57	5	DCs	DCs	NNP
cord-001293-dfaxj3bv	57	6	,	,	,
cord-001293-dfaxj3bv	57	7	and	and	CC
cord-001293-dfaxj3bv	57	8	NK	NK	NNP
cord-001293-dfaxj3bv	57	9	cells	cell	NNS
cord-001293-dfaxj3bv	57	10	is	be	VBZ
cord-001293-dfaxj3bv	57	11	a	a	DT
cord-001293-dfaxj3bv	57	12	hallmark	hallmark	NN
cord-001293-dfaxj3bv	57	13	of	of	IN
cord-001293-dfaxj3bv	57	14	sepsis	sepsis	NN
cord-001293-dfaxj3bv	57	15	.	.	.
cord-001293-dfaxj3bv	58	1	Hotchkiss	Hotchkiss	NNP
cord-001293-dfaxj3bv	58	2	and	and	CC
cord-001293-dfaxj3bv	58	3	colleagues	colleague	NNS
cord-001293-dfaxj3bv	58	4	[	[	-LRB-
cord-001293-dfaxj3bv	58	5	24	24	CD
cord-001293-dfaxj3bv	58	6	]	]	-RRB-
cord-001293-dfaxj3bv	58	7	provided	provide	VBN
cord-001293-dfaxj3bv	58	8	key	key	JJ
cord-001293-dfaxj3bv	58	9	experiments	experiment	NNS
cord-001293-dfaxj3bv	58	10	demonstrating	demonstrate	VBG
cord-001293-dfaxj3bv	58	11	that	that	IN
cord-001293-dfaxj3bv	58	12	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	58	13	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	58	14	was	be	VBD
cord-001293-dfaxj3bv	58	15	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	58	16	and	and	CC
cord-001293-dfaxj3bv	58	17	its	-PRON-	PRP$
cord-001293-dfaxj3bv	58	18	prevention	prevention	NN
cord-001293-dfaxj3bv	58	19	highly	highly	RB
cord-001293-dfaxj3bv	58	20	protective	protective	JJ
cord-001293-dfaxj3bv	58	21	.	.	.
cord-001293-dfaxj3bv	59	1	In	in	IN
cord-001293-dfaxj3bv	59	2	addition	addition	NN
cord-001293-dfaxj3bv	59	3	to	to	IN
cord-001293-dfaxj3bv	59	4	the	the	DT
cord-001293-dfaxj3bv	59	5	depletion	depletion	NN
cord-001293-dfaxj3bv	59	6	of	of	IN
cord-001293-dfaxj3bv	59	7	apoptotic	apoptotic	JJ
cord-001293-dfaxj3bv	59	8	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	59	9	that	that	WDT
cord-001293-dfaxj3bv	59	10	contribute	contribute	VBP
cord-001293-dfaxj3bv	59	11	to	to	IN
cord-001293-dfaxj3bv	59	12	the	the	DT
cord-001293-dfaxj3bv	59	13	alteration	alteration	NN
cord-001293-dfaxj3bv	59	14	of	of	IN
cord-001293-dfaxj3bv	59	15	the	the	DT
cord-001293-dfaxj3bv	59	16	immune	immune	JJ
cord-001293-dfaxj3bv	59	17	status	status	NN
cord-001293-dfaxj3bv	59	18	,	,	,
cord-001293-dfaxj3bv	59	19	apoptotic	apoptotic	JJ
cord-001293-dfaxj3bv	59	20	T	t	NN
cord-001293-dfaxj3bv	59	21	cells	cell	NNS
cord-001293-dfaxj3bv	59	22	themselves	-PRON-	PRP
cord-001293-dfaxj3bv	59	23	can	can	MD
cord-001293-dfaxj3bv	59	24	further	further	RB
cord-001293-dfaxj3bv	59	25	produce	produce	VB
cord-001293-dfaxj3bv	59	26	an	an	DT
cord-001293-dfaxj3bv	59	27	immunosuppressive	immunosuppressive	JJ
cord-001293-dfaxj3bv	59	28	milieu	milieu	NN
cord-001293-dfaxj3bv	59	29	following	follow	VBG
cord-001293-dfaxj3bv	59	30	their	-PRON-	PRP$
cord-001293-dfaxj3bv	59	31	release	release	NN
cord-001293-dfaxj3bv	59	32	of	of	IN
cord-001293-dfaxj3bv	59	33	TGFβ	TGFβ	NNS
cord-001293-dfaxj3bv	59	34	[	[	-LRB-
cord-001293-dfaxj3bv	59	35	25	25	CD
cord-001293-dfaxj3bv	59	36	]	]	-RRB-
cord-001293-dfaxj3bv	59	37	.	.	.
cord-001293-dfaxj3bv	60	1	In	in	IN
cord-001293-dfaxj3bv	60	2	contrast	contrast	NN
cord-001293-dfaxj3bv	60	3	,	,	,
cord-001293-dfaxj3bv	60	4	the	the	DT
cord-001293-dfaxj3bv	60	5	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	60	6	of	of	IN
cord-001293-dfaxj3bv	60	7	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	60	8	is	be	VBZ
cord-001293-dfaxj3bv	60	9	reduced	reduce	VBN
cord-001293-dfaxj3bv	60	10	.	.	.
cord-001293-dfaxj3bv	61	1	Interestingly	interestingly	RB
cord-001293-dfaxj3bv	61	2	,	,	,
cord-001293-dfaxj3bv	61	3	injection	injection	NN
cord-001293-dfaxj3bv	61	4	of	of	IN
cord-001293-dfaxj3bv	61	5	apoptotic	apoptotic	JJ
cord-001293-dfaxj3bv	61	6	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	61	7	in	in	IN
cord-001293-dfaxj3bv	61	8	LPS	LPS	NNP
cord-001293-dfaxj3bv	61	9	-	-	HYPH
cord-001293-dfaxj3bv	61	10	challenged	challenge	VBN
cord-001293-dfaxj3bv	61	11	mice	mouse	NNS
cord-001293-dfaxj3bv	61	12	with	with	IN
cord-001293-dfaxj3bv	61	13	or	or	CC
cord-001293-dfaxj3bv	61	14	undergoing	undergo	VBG
cord-001293-dfaxj3bv	61	15	cecal	cecal	JJ
cord-001293-dfaxj3bv	61	16	ligature	ligature	NN
cord-001293-dfaxj3bv	61	17	puncture	puncture	NN
cord-001293-dfaxj3bv	61	18	improved	improve	VBN
cord-001293-dfaxj3bv	61	19	outcomes	outcome	NNS
cord-001293-dfaxj3bv	61	20	[	[	-LRB-
cord-001293-dfaxj3bv	61	21	26	26	CD
cord-001293-dfaxj3bv	61	22	]	]	-RRB-
cord-001293-dfaxj3bv	61	23	.	.	.
cord-001293-dfaxj3bv	62	1	This	this	DT
cord-001293-dfaxj3bv	62	2	may	may	MD
cord-001293-dfaxj3bv	62	3	be	be	VB
cord-001293-dfaxj3bv	62	4	due	due	JJ
cord-001293-dfaxj3bv	62	5	to	to	IN
cord-001293-dfaxj3bv	62	6	the	the	DT
cord-001293-dfaxj3bv	62	7	capacity	capacity	NN
cord-001293-dfaxj3bv	62	8	of	of	IN
cord-001293-dfaxj3bv	62	9	apoptotic	apoptotic	JJ
cord-001293-dfaxj3bv	62	10	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	62	11	to	to	TO
cord-001293-dfaxj3bv	62	12	limit	limit	VB
cord-001293-dfaxj3bv	62	13	the	the	DT
cord-001293-dfaxj3bv	62	14	production	production	NN
cord-001293-dfaxj3bv	62	15	of	of	IN
cord-001293-dfaxj3bv	62	16	IL-1	IL-1	NNP
cord-001293-dfaxj3bv	62	17	and	and	CC
cord-001293-dfaxj3bv	62	18	TNF	TNF	NNP
cord-001293-dfaxj3bv	62	19	by	by	IN
cord-001293-dfaxj3bv	62	20	LPS	LPS	NNP
cord-001293-dfaxj3bv	62	21	-	-	HYPH
cord-001293-dfaxj3bv	62	22	activated	activate	VBN
cord-001293-dfaxj3bv	62	23	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	62	24	and	and	CC
cord-001293-dfaxj3bv	62	25	to	to	TO
cord-001293-dfaxj3bv	62	26	favor	favor	VB
cord-001293-dfaxj3bv	62	27	the	the	DT
cord-001293-dfaxj3bv	62	28	production	production	NN
cord-001293-dfaxj3bv	62	29	of	of	IN
cord-001293-dfaxj3bv	62	30	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	62	31	and	and	CC
cord-001293-dfaxj3bv	62	32	TGFβ	TGFβ	NNP
cord-001293-dfaxj3bv	62	33	[	[	-LRB-
cord-001293-dfaxj3bv	62	34	27	27	CD
cord-001293-dfaxj3bv	62	35	]	]	-RRB-
cord-001293-dfaxj3bv	62	36	.	.	.
cord-001293-dfaxj3bv	63	1	Favoring	favor	VBG
cord-001293-dfaxj3bv	63	2	neutrophil	neutrophil	NN
cord-001293-dfaxj3bv	63	3	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	63	4	while	while	IN
cord-001293-dfaxj3bv	63	5	differentially	differentially	RB
cord-001293-dfaxj3bv	63	6	preventing	prevent	VBG
cord-001293-dfaxj3bv	63	7	that	that	DT
cord-001293-dfaxj3bv	63	8	of	of	IN
cord-001293-dfaxj3bv	63	9	lymphocytes	lymphocyte	NNS
cord-001293-dfaxj3bv	63	10	and	and	CC
cord-001293-dfaxj3bv	63	11	DCs	dc	NNS
cord-001293-dfaxj3bv	63	12	would	would	MD
cord-001293-dfaxj3bv	63	13	represent	represent	VB
cord-001293-dfaxj3bv	63	14	a	a	DT
cord-001293-dfaxj3bv	63	15	considerable	considerable	JJ
cord-001293-dfaxj3bv	63	16	interventional	interventional	JJ
cord-001293-dfaxj3bv	63	17	challenge	challenge	NN
cord-001293-dfaxj3bv	63	18	!	!	.
cord-001293-dfaxj3bv	64	1	In	in	IN
cord-001293-dfaxj3bv	64	2	sepsis	sepsis	NN
cord-001293-dfaxj3bv	64	3	,	,	,
cord-001293-dfaxj3bv	64	4	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	64	5	does	do	VBZ
cord-001293-dfaxj3bv	64	6	not	not	RB
cord-001293-dfaxj3bv	64	7	only	only	RB
cord-001293-dfaxj3bv	64	8	affect	affect	VB
cord-001293-dfaxj3bv	64	9	immune	immune	JJ
cord-001293-dfaxj3bv	64	10	cells	cell	NNS
cord-001293-dfaxj3bv	64	11	.	.	.
cord-001293-dfaxj3bv	65	1	Apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	65	2	of	of	IN
cord-001293-dfaxj3bv	65	3	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	65	4	cells	cell	NNS
cord-001293-dfaxj3bv	65	5	,	,	,
cord-001293-dfaxj3bv	65	6	endothelial	endothelial	JJ
cord-001293-dfaxj3bv	65	7	cells	cell	NNS
cord-001293-dfaxj3bv	65	8	,	,	,
cord-001293-dfaxj3bv	65	9	neurons	neuron	NNS
cord-001293-dfaxj3bv	65	10	,	,	,
cord-001293-dfaxj3bv	65	11	and	and	CC
cord-001293-dfaxj3bv	65	12	cardiac	cardiac	JJ
cord-001293-dfaxj3bv	65	13	myocytes	myocyte	NNS
cord-001293-dfaxj3bv	65	14	is	be	VBZ
cord-001293-dfaxj3bv	65	15	reported	report	VBN
cord-001293-dfaxj3bv	65	16	with	with	IN
cord-001293-dfaxj3bv	65	17	crucial	crucial	JJ
cord-001293-dfaxj3bv	65	18	effects	effect	NNS
cord-001293-dfaxj3bv	65	19	of	of	IN
cord-001293-dfaxj3bv	65	20	loss	loss	NN
cord-001293-dfaxj3bv	65	21	of	of	IN
cord-001293-dfaxj3bv	65	22	altered	alter	VBN
cord-001293-dfaxj3bv	65	23	barrier	barrier	NN
cord-001293-dfaxj3bv	65	24	function	function	NN
cord-001293-dfaxj3bv	65	25	(	(	-LRB-
cord-001293-dfaxj3bv	65	26	Figure	figure	NN
cord-001293-dfaxj3bv	65	27	1	1	CD
cord-001293-dfaxj3bv	65	28	):	):	NN
cord-001293-dfaxj3bv	65	29	in	in	IN
cord-001293-dfaxj3bv	65	30	the	the	DT
cord-001293-dfaxj3bv	65	31	lungs	lung	NNS
cord-001293-dfaxj3bv	65	32	-acute	-acute	CD
cord-001293-dfaxj3bv	65	33	lung	lung	NN
cord-001293-dfaxj3bv	65	34	injury	injury	NN
cord-001293-dfaxj3bv	65	35	and	and	CC
cord-001293-dfaxj3bv	65	36	adult	adult	NN
cord-001293-dfaxj3bv	65	37	respiratory	respiratory	JJ
cord-001293-dfaxj3bv	65	38	response	response	NN
cord-001293-dfaxj3bv	65	39	syndrome	syndrome	NN
cord-001293-dfaxj3bv	65	40	[	[	-LRB-
cord-001293-dfaxj3bv	65	41	28	28	CD
cord-001293-dfaxj3bv	65	42	]	]	-RRB-
cord-001293-dfaxj3bv	65	43	;	;	:
cord-001293-dfaxj3bv	65	44	in	in	IN
cord-001293-dfaxj3bv	65	45	the	the	DT
cord-001293-dfaxj3bv	65	46	kidneys	kidney	NNS
cord-001293-dfaxj3bv	65	47	-acute	-acute	CD
cord-001293-dfaxj3bv	65	48	kidney	kidney	NN
cord-001293-dfaxj3bv	65	49	injury	injury	NN
cord-001293-dfaxj3bv	65	50	[	[	-LRB-
cord-001293-dfaxj3bv	65	51	29	29	CD
cord-001293-dfaxj3bv	65	52	]	]	-RRB-
cord-001293-dfaxj3bv	65	53	.	.	.
cord-001293-dfaxj3bv	66	1	Enhanced	enhanced	JJ
cord-001293-dfaxj3bv	66	2	translocation	translocation	NN
cord-001293-dfaxj3bv	66	3	of	of	IN
cord-001293-dfaxj3bv	66	4	bacteria	bacteria	NNS
cord-001293-dfaxj3bv	66	5	and	and	CC
cord-001293-dfaxj3bv	66	6	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	66	7	products	product	NNS
cord-001293-dfaxj3bv	66	8	occurs	occur	VBZ
cord-001293-dfaxj3bv	66	9	consequent	consequent	NN
cord-001293-dfaxj3bv	66	10	on	on	IN
cord-001293-dfaxj3bv	66	11	intestinal	intestinal	JJ
cord-001293-dfaxj3bv	66	12	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	66	13	cell	cell	NN
cord-001293-dfaxj3bv	66	14	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	66	15	[	[	-LRB-
cord-001293-dfaxj3bv	66	16	30	30	CD
cord-001293-dfaxj3bv	66	17	]	]	-RRB-
cord-001293-dfaxj3bv	66	18	,	,	,
cord-001293-dfaxj3bv	66	19	contributing	contribute	VBG
cord-001293-dfaxj3bv	66	20	to	to	IN
cord-001293-dfaxj3bv	66	21	the	the	DT
cord-001293-dfaxj3bv	66	22	concept	concept	NN
cord-001293-dfaxj3bv	66	23	of	of	IN
cord-001293-dfaxj3bv	66	24	the	the	DT
cord-001293-dfaxj3bv	66	25	gut	gut	NN
cord-001293-dfaxj3bv	66	26	as	as	IN
cord-001293-dfaxj3bv	66	27	the	the	DT
cord-001293-dfaxj3bv	66	28	motor	motor	NN
cord-001293-dfaxj3bv	66	29	of	of	IN
cord-001293-dfaxj3bv	66	30	multiple	multiple	JJ
cord-001293-dfaxj3bv	66	31	organ	organ	NN
cord-001293-dfaxj3bv	66	32	failure	failure	NN
cord-001293-dfaxj3bv	66	33	(	(	-LRB-
cord-001293-dfaxj3bv	66	34	MOF	MOF	NNP
cord-001293-dfaxj3bv	66	35	)	)	-RRB-
cord-001293-dfaxj3bv	66	36	.	.	.
cord-001293-dfaxj3bv	67	1	Sepsis	sepsis	NN
cord-001293-dfaxj3bv	67	2	-	-	HYPH
cord-001293-dfaxj3bv	67	3	induced	induce	VBN
cord-001293-dfaxj3bv	67	4	cardiac	cardiac	NN
cord-001293-dfaxj3bv	67	5	myocyte	myocyte	NN
cord-001293-dfaxj3bv	67	6	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	67	7	produces	produce	VBZ
cord-001293-dfaxj3bv	67	8	altered	alter	VBN
cord-001293-dfaxj3bv	67	9	contractility	contractility	NN
cord-001293-dfaxj3bv	67	10	and	and	CC
cord-001293-dfaxj3bv	67	11	cardiac	cardiac	JJ
cord-001293-dfaxj3bv	67	12	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	67	13	[	[	-LRB-
cord-001293-dfaxj3bv	67	14	31	31	CD
cord-001293-dfaxj3bv	67	15	]	]	-RRB-
cord-001293-dfaxj3bv	67	16	.	.	.
cord-001293-dfaxj3bv	68	1	Apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	68	2	of	of	IN
cord-001293-dfaxj3bv	68	3	endothelial	endothelial	JJ
cord-001293-dfaxj3bv	68	4	cells	cell	NNS
cord-001293-dfaxj3bv	68	5	[	[	-LRB-
cord-001293-dfaxj3bv	68	6	32	32	CD
cord-001293-dfaxj3bv	68	7	]	]	-RRB-
cord-001293-dfaxj3bv	68	8	induces	induce	VBZ
cord-001293-dfaxj3bv	68	9	vascular	vascular	JJ
cord-001293-dfaxj3bv	68	10	leakage	leakage	NN
cord-001293-dfaxj3bv	68	11	.	.	.
cord-001293-dfaxj3bv	69	1	Finally	finally	RB
cord-001293-dfaxj3bv	69	2	,	,	,
cord-001293-dfaxj3bv	69	3	microglial	microglial	JJ
cord-001293-dfaxj3bv	69	4	and	and	CC
cord-001293-dfaxj3bv	69	5	neuronal	neuronal	JJ
cord-001293-dfaxj3bv	69	6	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	69	7	may	may	MD
cord-001293-dfaxj3bv	69	8	follow	follow	VB
cord-001293-dfaxj3bv	69	9	autonomic	autonomic	JJ
cord-001293-dfaxj3bv	69	10	failure	failure	NN
cord-001293-dfaxj3bv	69	11	that	that	WDT
cord-001293-dfaxj3bv	69	12	precedes	precede	VBZ
cord-001293-dfaxj3bv	69	13	shock	shock	NN
cord-001293-dfaxj3bv	69	14	and	and	CC
cord-001293-dfaxj3bv	69	15	MOF	MOF	NNP
cord-001293-dfaxj3bv	69	16	[	[	-LRB-
cord-001293-dfaxj3bv	69	17	33	33	CD
cord-001293-dfaxj3bv	69	18	]	]	-RRB-
cord-001293-dfaxj3bv	69	19	.	.	.
cord-001293-dfaxj3bv	70	1	In	in	IN
cord-001293-dfaxj3bv	70	2	addition	addition	NN
cord-001293-dfaxj3bv	70	3	to	to	IN
cord-001293-dfaxj3bv	70	4	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	70	5	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	70	6	,	,	,
cord-001293-dfaxj3bv	70	7	tight	tight	JJ
cord-001293-dfaxj3bv	70	8	junction	junction	NN
cord-001293-dfaxj3bv	70	9	alterations	alteration	NNS
cord-001293-dfaxj3bv	70	10	enhance	enhance	VBP
cord-001293-dfaxj3bv	70	11	organ	organ	NN
cord-001293-dfaxj3bv	70	12	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	70	13	.	.	.
cord-001293-dfaxj3bv	71	1	It	-PRON-	PRP
cord-001293-dfaxj3bv	71	2	has	have	VBZ
cord-001293-dfaxj3bv	71	3	been	be	VBN
cord-001293-dfaxj3bv	71	4	demonstrated	demonstrate	VBN
cord-001293-dfaxj3bv	71	5	that	that	IN
cord-001293-dfaxj3bv	71	6	nitric	nitric	JJ
cord-001293-dfaxj3bv	71	7	oxide	oxide	NN
cord-001293-dfaxj3bv	71	8	favors	favor	VBZ
cord-001293-dfaxj3bv	71	9	disruption	disruption	NN
cord-001293-dfaxj3bv	71	10	of	of	IN
cord-001293-dfaxj3bv	71	11	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	71	12	cell	cell	NN
cord-001293-dfaxj3bv	71	13	tight	tight	JJ
cord-001293-dfaxj3bv	71	14	junctions	junction	NNS
cord-001293-dfaxj3bv	71	15	in	in	IN
cord-001293-dfaxj3bv	71	16	numerous	numerous	JJ
cord-001293-dfaxj3bv	71	17	organs	organ	NNS
cord-001293-dfaxj3bv	71	18	,	,	,
cord-001293-dfaxj3bv	71	19	including	include	VBG
cord-001293-dfaxj3bv	71	20	liver	liver	NN
cord-001293-dfaxj3bv	71	21	,	,	,
cord-001293-dfaxj3bv	71	22	gut	gut	NN
cord-001293-dfaxj3bv	71	23	,	,	,
cord-001293-dfaxj3bv	71	24	and	and	CC
cord-001293-dfaxj3bv	71	25	lung	lung	NN
cord-001293-dfaxj3bv	71	26	.	.	.
cord-001293-dfaxj3bv	72	1	Leukotrienes	leukotriene	NNS
cord-001293-dfaxj3bv	72	2	favor	favor	VBP
cord-001293-dfaxj3bv	72	3	protein	protein	NN
cord-001293-dfaxj3bv	72	4	extravasation	extravasation	NN
cord-001293-dfaxj3bv	72	5	as	as	IN
cord-001293-dfaxj3bv	72	6	shown	show	VBN
cord-001293-dfaxj3bv	72	7	in	in	IN
cord-001293-dfaxj3bv	72	8	the	the	DT
cord-001293-dfaxj3bv	72	9	kidney	kidney	NN
cord-001293-dfaxj3bv	72	10	of	of	IN
cord-001293-dfaxj3bv	72	11	septic	septic	JJ
cord-001293-dfaxj3bv	72	12	mice	mouse	NNS
cord-001293-dfaxj3bv	72	13	[	[	-LRB-
cord-001293-dfaxj3bv	72	14	34	34	CD
cord-001293-dfaxj3bv	72	15	]	]	-RRB-
cord-001293-dfaxj3bv	72	16	.	.	.
cord-001293-dfaxj3bv	73	1	Still	still	RB
cord-001293-dfaxj3bv	73	2	,	,	,
cord-001293-dfaxj3bv	73	3	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	73	4	remain	remain	VBP
cord-001293-dfaxj3bv	73	5	the	the	DT
cord-001293-dfaxj3bv	73	6	main	main	JJ
cord-001293-dfaxj3bv	73	7	orchestrators	orchestrator	NNS
cord-001293-dfaxj3bv	73	8	of	of	IN
cord-001293-dfaxj3bv	73	9	these	these	DT
cord-001293-dfaxj3bv	73	10	tissue	tissue	NN
cord-001293-dfaxj3bv	73	11	injuries	injury	NNS
cord-001293-dfaxj3bv	73	12	.	.	.
cord-001293-dfaxj3bv	74	1	In	in	IN
cord-001293-dfaxj3bv	74	2	a	a	DT
cord-001293-dfaxj3bv	74	3	model	model	NN
cord-001293-dfaxj3bv	74	4	of	of	IN
cord-001293-dfaxj3bv	74	5	acute	acute	JJ
cord-001293-dfaxj3bv	74	6	kidney	kidney	NN
cord-001293-dfaxj3bv	74	7	injury	injury	NN
cord-001293-dfaxj3bv	74	8	,	,	,
cord-001293-dfaxj3bv	74	9	it	-PRON-	PRP
cord-001293-dfaxj3bv	74	10	was	be	VBD
cord-001293-dfaxj3bv	74	11	nicely	nicely	RB
cord-001293-dfaxj3bv	74	12	demonstrated	demonstrate	VBN
cord-001293-dfaxj3bv	74	13	that	that	IN
cord-001293-dfaxj3bv	74	14	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	74	15	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	74	16	,	,	,
cord-001293-dfaxj3bv	74	17	including	include	VBG
cord-001293-dfaxj3bv	74	18	TNF	TNF	NNP
cord-001293-dfaxj3bv	74	19	and	and	CC
cord-001293-dfaxj3bv	74	20	IL-17	IL-17	NNP
cord-001293-dfaxj3bv	74	21	,	,	,
cord-001293-dfaxj3bv	74	22	cause	cause	VB
cord-001293-dfaxj3bv	74	23	small	small	JJ
cord-001293-dfaxj3bv	74	24	intestine	intestine	NN
cord-001293-dfaxj3bv	74	25	and	and	CC
cord-001293-dfaxj3bv	74	26	liver	liver	NN
cord-001293-dfaxj3bv	74	27	injury	injury	NN
cord-001293-dfaxj3bv	74	28	[	[	-LRB-
cord-001293-dfaxj3bv	74	29	35	35	CD
cord-001293-dfaxj3bv	74	30	]	]	-RRB-
cord-001293-dfaxj3bv	74	31	.	.	.
cord-001293-dfaxj3bv	75	1	Among	among	IN
cord-001293-dfaxj3bv	75	2	others	other	NNS
cord-001293-dfaxj3bv	75	3	,	,	,
cord-001293-dfaxj3bv	75	4	IL-17A	IL-17A	NNP
cord-001293-dfaxj3bv	75	5	is	be	VBZ
cord-001293-dfaxj3bv	75	6	critical	critical	JJ
cord-001293-dfaxj3bv	75	7	for	for	IN
cord-001293-dfaxj3bv	75	8	generation	generation	NN
cord-001293-dfaxj3bv	75	9	of	of	IN
cord-001293-dfaxj3bv	75	10	intestinal	intestinal	JJ
cord-001293-dfaxj3bv	75	11	ischemia	ischemia	NN
cord-001293-dfaxj3bv	75	12	/	/	SYM
cord-001293-dfaxj3bv	75	13	reperfusion	reperfusion	NN
cord-001293-dfaxj3bv	75	14	injury	injury	NN
cord-001293-dfaxj3bv	75	15	and	and	CC
cord-001293-dfaxj3bv	75	16	subsequent	subsequent	JJ
cord-001293-dfaxj3bv	75	17	liver	liver	NN
cord-001293-dfaxj3bv	75	18	and	and	CC
cord-001293-dfaxj3bv	75	19	kidney	kidney	NN
cord-001293-dfaxj3bv	75	20	injury	injury	NN
cord-001293-dfaxj3bv	75	21	[	[	-LRB-
cord-001293-dfaxj3bv	75	22	36	36	CD
cord-001293-dfaxj3bv	75	23	]	]	-RRB-
cord-001293-dfaxj3bv	75	24	.	.	.
cord-001293-dfaxj3bv	76	1	All	all	RB
cord-001293-dfaxj3bv	76	2	together	together	RB
cord-001293-dfaxj3bv	76	3	,	,	,
cord-001293-dfaxj3bv	76	4	the	the	DT
cord-001293-dfaxj3bv	76	5	altered	alter	VBN
cord-001293-dfaxj3bv	76	6	functions	function	NNS
cord-001293-dfaxj3bv	76	7	of	of	IN
cord-001293-dfaxj3bv	76	8	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	76	9	cells	cell	NNS
cord-001293-dfaxj3bv	76	10	,	,	,
cord-001293-dfaxj3bv	76	11	endothelial	endothelial	JJ
cord-001293-dfaxj3bv	76	12	cells	cell	NNS
cord-001293-dfaxj3bv	76	13	,	,	,
cord-001293-dfaxj3bv	76	14	neurons	neuron	NNS
cord-001293-dfaxj3bv	76	15	,	,	,
cord-001293-dfaxj3bv	76	16	and	and	CC
cord-001293-dfaxj3bv	76	17	cardiac	cardiac	JJ
cord-001293-dfaxj3bv	76	18	myocytes	myocyte	NNS
cord-001293-dfaxj3bv	76	19	contribute	contribute	VBP
cord-001293-dfaxj3bv	76	20	to	to	IN
cord-001293-dfaxj3bv	76	21	MOF	MOF	NNP
cord-001293-dfaxj3bv	76	22	that	that	WDT
cord-001293-dfaxj3bv	76	23	may	may	MD
cord-001293-dfaxj3bv	76	24	influence	influence	VB
cord-001293-dfaxj3bv	76	25	outcomes	outcome	NNS
cord-001293-dfaxj3bv	76	26	in	in	IN
cord-001293-dfaxj3bv	76	27	sepsis	sepsis	NN
cord-001293-dfaxj3bv	76	28	more	more	RBR
cord-001293-dfaxj3bv	76	29	than	than	IN
cord-001293-dfaxj3bv	76	30	altered	alter	VBN
cord-001293-dfaxj3bv	76	31	immune	immune	JJ
cord-001293-dfaxj3bv	76	32	status	status	NN
cord-001293-dfaxj3bv	76	33	.	.	.
cord-001293-dfaxj3bv	77	1	The	the	DT
cord-001293-dfaxj3bv	77	2	concomitant	concomitant	JJ
cord-001293-dfaxj3bv	77	3	occurrence	occurrence	NN
cord-001293-dfaxj3bv	77	4	of	of	IN
cord-001293-dfaxj3bv	77	5	inflammation	inflammation	NN
cord-001293-dfaxj3bv	77	6	,	,	,
cord-001293-dfaxj3bv	77	7	anti	anti	JJ
cord-001293-dfaxj3bv	77	8	-	-	JJ
cord-001293-dfaxj3bv	77	9	infectious	infectious	JJ
cord-001293-dfaxj3bv	77	10	response	response	NN
cord-001293-dfaxj3bv	77	11	,	,	,
cord-001293-dfaxj3bv	77	12	and	and	CC
cord-001293-dfaxj3bv	77	13	altered	alter	VBN
cord-001293-dfaxj3bv	77	14	immune	immune	JJ
cord-001293-dfaxj3bv	77	15	status	status	NN
cord-001293-dfaxj3bv	77	16	in	in	IN
cord-001293-dfaxj3bv	77	17	sepsis	sepsis	NN
cord-001293-dfaxj3bv	78	1	When	when	WRB
cord-001293-dfaxj3bv	78	2	Roger	Roger	NNP
cord-001293-dfaxj3bv	78	3	Bone	Bone	NNP
cord-001293-dfaxj3bv	78	4	coined	coin	VBD
cord-001293-dfaxj3bv	78	5	the	the	DT
cord-001293-dfaxj3bv	78	6	concepts	concept	NNS
cord-001293-dfaxj3bv	78	7	of	of	IN
cord-001293-dfaxj3bv	78	8	systemic	systemic	JJ
cord-001293-dfaxj3bv	78	9	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	78	10	response	response	NN
cord-001293-dfaxj3bv	78	11	syndrome	syndrome	NN
cord-001293-dfaxj3bv	78	12	(	(	-LRB-
cord-001293-dfaxj3bv	78	13	SIRS	SIRS	NNP
cord-001293-dfaxj3bv	78	14	)	)	-RRB-
cord-001293-dfaxj3bv	78	15	and	and	CC
cord-001293-dfaxj3bv	78	16	compensatory	compensatory	JJ
cord-001293-dfaxj3bv	78	17	anti	anti	JJ
cord-001293-dfaxj3bv	78	18	-	-	JJ
cord-001293-dfaxj3bv	78	19	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	78	20	response	response	NN
cord-001293-dfaxj3bv	78	21	syndrome	syndrome	NN
cord-001293-dfaxj3bv	78	22	(	(	-LRB-
cord-001293-dfaxj3bv	78	23	CARS	car	NNS
cord-001293-dfaxj3bv	78	24	)	)	-RRB-
cord-001293-dfaxj3bv	78	25	,	,	,
cord-001293-dfaxj3bv	78	26	he	-PRON-	PRP
cord-001293-dfaxj3bv	78	27	conceived	conceive	VBD
cord-001293-dfaxj3bv	78	28	that	that	IN
cord-001293-dfaxj3bv	78	29	one	one	CD
cord-001293-dfaxj3bv	78	30	or	or	CC
cord-001293-dfaxj3bv	78	31	the	the	DT
cord-001293-dfaxj3bv	78	32	other	other	JJ
cord-001293-dfaxj3bv	78	33	would	would	MD
cord-001293-dfaxj3bv	78	34	be	be	VB
cord-001293-dfaxj3bv	78	35	predominating	predominate	VBG
cord-001293-dfaxj3bv	78	36	Figure	figure	NN
cord-001293-dfaxj3bv	78	37	1	1	CD
cord-001293-dfaxj3bv	79	1	During	during	IN
cord-001293-dfaxj3bv	79	2	sepsis	sepsis	NN
cord-001293-dfaxj3bv	79	3	,	,	,
cord-001293-dfaxj3bv	79	4	many	many	JJ
cord-001293-dfaxj3bv	79	5	types	type	NNS
cord-001293-dfaxj3bv	79	6	of	of	IN
cord-001293-dfaxj3bv	79	7	cells	cell	NNS
cord-001293-dfaxj3bv	79	8	(	(	-LRB-
cord-001293-dfaxj3bv	79	9	but	but	CC
cord-001293-dfaxj3bv	79	10	not	not	RB
cord-001293-dfaxj3bv	79	11	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	79	12	)	)	-RRB-
cord-001293-dfaxj3bv	79	13	display	display	NN
cord-001293-dfaxj3bv	79	14	enhanced	enhance	VBN
cord-001293-dfaxj3bv	79	15	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	79	16	,	,	,
cord-001293-dfaxj3bv	79	17	leading	lead	VBG
cord-001293-dfaxj3bv	79	18	to	to	IN
cord-001293-dfaxj3bv	79	19	various	various	JJ
cord-001293-dfaxj3bv	79	20	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	79	21	consequences	consequence	NNS
cord-001293-dfaxj3bv	79	22	.	.	.
cord-001293-dfaxj3bv	80	1	AKI	AKI	NNP
cord-001293-dfaxj3bv	80	2	,	,	,
cord-001293-dfaxj3bv	80	3	acute	acute	JJ
cord-001293-dfaxj3bv	80	4	kidney	kidney	NN
cord-001293-dfaxj3bv	80	5	injury	injury	NN
cord-001293-dfaxj3bv	80	6	;	;	:
cord-001293-dfaxj3bv	80	7	ALI	ALI	NNP
cord-001293-dfaxj3bv	80	8	/	/	SYM
cord-001293-dfaxj3bv	80	9	ARDS	ARDS	NNP
cord-001293-dfaxj3bv	80	10	,	,	,
cord-001293-dfaxj3bv	80	11	acute	acute	JJ
cord-001293-dfaxj3bv	80	12	lung	lung	NN
cord-001293-dfaxj3bv	80	13	injury	injury	NN
cord-001293-dfaxj3bv	80	14	/	/	SYM
cord-001293-dfaxj3bv	80	15	acute	acute	JJ
cord-001293-dfaxj3bv	80	16	respiratory	respiratory	JJ
cord-001293-dfaxj3bv	80	17	distress	distress	NN
cord-001293-dfaxj3bv	80	18	syndrome	syndrome	NN
cord-001293-dfaxj3bv	80	19	;	;	:
cord-001293-dfaxj3bv	80	20	NK	NK	NNP
cord-001293-dfaxj3bv	80	21	,	,	,
cord-001293-dfaxj3bv	80	22	natural	natural	JJ
cord-001293-dfaxj3bv	80	23	killer	killer	NN
cord-001293-dfaxj3bv	80	24	.	.	.
cord-001293-dfaxj3bv	81	1	[	[	-LRB-
cord-001293-dfaxj3bv	81	2	37	37	CD
cord-001293-dfaxj3bv	81	3	]	]	-RRB-
cord-001293-dfaxj3bv	81	4	.	.	.
cord-001293-dfaxj3bv	82	1	However	however	RB
cord-001293-dfaxj3bv	82	2	,	,	,
cord-001293-dfaxj3bv	82	3	we	-PRON-	PRP
cord-001293-dfaxj3bv	82	4	contend	contend	VBP
cord-001293-dfaxj3bv	82	5	that	that	IN
cord-001293-dfaxj3bv	82	6	CARS	car	NNS
cord-001293-dfaxj3bv	82	7	should	should	MD
cord-001293-dfaxj3bv	82	8	be	be	VB
cord-001293-dfaxj3bv	82	9	considered	consider	VBN
cord-001293-dfaxj3bv	82	10	an	an	DT
cord-001293-dfaxj3bv	82	11	adapted	adapt	VBN
cord-001293-dfaxj3bv	82	12	compartmentalized	compartmentalize	VBN
cord-001293-dfaxj3bv	82	13	response	response	NN
cord-001293-dfaxj3bv	82	14	with	with	IN
cord-001293-dfaxj3bv	82	15	the	the	DT
cord-001293-dfaxj3bv	82	16	aim	aim	NN
cord-001293-dfaxj3bv	82	17	of	of	IN
cord-001293-dfaxj3bv	82	18	silencing	silence	VBG
cord-001293-dfaxj3bv	82	19	some	some	DT
cord-001293-dfaxj3bv	82	20	acute	acute	JJ
cord-001293-dfaxj3bv	82	21	pro	pro	JJ
cord-001293-dfaxj3bv	82	22	-	-	JJ
cord-001293-dfaxj3bv	82	23	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	82	24	genes	gene	NNS
cord-001293-dfaxj3bv	82	25	and	and	CC
cord-001293-dfaxj3bv	82	26	maintaining	maintain	VBG
cord-001293-dfaxj3bv	82	27	the	the	DT
cord-001293-dfaxj3bv	82	28	expression	expression	NN
cord-001293-dfaxj3bv	82	29	of	of	IN
cord-001293-dfaxj3bv	82	30	certain	certain	JJ
cord-001293-dfaxj3bv	82	31	genes	gene	NNS
cord-001293-dfaxj3bv	82	32	involved	involve	VBN
cord-001293-dfaxj3bv	82	33	in	in	IN
cord-001293-dfaxj3bv	82	34	the	the	DT
cord-001293-dfaxj3bv	82	35	anti	anti	JJ
cord-001293-dfaxj3bv	82	36	-	-	JJ
cord-001293-dfaxj3bv	82	37	infectious	infectious	JJ
cord-001293-dfaxj3bv	82	38	process	process	NN
cord-001293-dfaxj3bv	82	39	.	.	.
cord-001293-dfaxj3bv	83	1	Despite	despite	IN
cord-001293-dfaxj3bv	83	2	our	-PRON-	PRP$
cord-001293-dfaxj3bv	83	3	views	view	NNS
cord-001293-dfaxj3bv	83	4	[	[	-LRB-
cord-001293-dfaxj3bv	83	5	38	38	CD
cord-001293-dfaxj3bv	83	6	]	]	-RRB-
cord-001293-dfaxj3bv	83	7	,	,	,
cord-001293-dfaxj3bv	83	8	authors	author	NNS
cord-001293-dfaxj3bv	83	9	still	still	RB
cord-001293-dfaxj3bv	83	10	propose	propose	VBP
cord-001293-dfaxj3bv	83	11	a	a	DT
cord-001293-dfaxj3bv	83	12	two	two	CD
cord-001293-dfaxj3bv	83	13	-	-	HYPH
cord-001293-dfaxj3bv	83	14	wave	wave	NN
cord-001293-dfaxj3bv	83	15	concept	concept	NN
cord-001293-dfaxj3bv	83	16	with	with	IN
cord-001293-dfaxj3bv	83	17	SIRS	SIRS	NNP
cord-001293-dfaxj3bv	83	18	appearing	appear	VBG
cord-001293-dfaxj3bv	83	19	before	before	IN
cord-001293-dfaxj3bv	83	20	CARS	car	NNS
cord-001293-dfaxj3bv	83	21	,	,	,
cord-001293-dfaxj3bv	83	22	although	although	IN
cord-001293-dfaxj3bv	83	23	they	-PRON-	PRP
cord-001293-dfaxj3bv	83	24	admit	admit	VBP
cord-001293-dfaxj3bv	83	25	that	that	IN
cord-001293-dfaxj3bv	83	26	'	'	``
cord-001293-dfaxj3bv	83	27	rigorous	rigorous	JJ
cord-001293-dfaxj3bv	83	28	examination	examination	NN
cord-001293-dfaxj3bv	83	29	of	of	IN
cord-001293-dfaxj3bv	83	30	previous	previous	JJ
cord-001293-dfaxj3bv	83	31	studies	study	NNS
cord-001293-dfaxj3bv	83	32	provides	provide	VBZ
cord-001293-dfaxj3bv	83	33	evidence	evidence	NN
cord-001293-dfaxj3bv	83	34	that	that	IN
cord-001293-dfaxj3bv	83	35	both	both	CC
cord-001293-dfaxj3bv	83	36	proinflammatory	proinflammatory	JJ
cord-001293-dfaxj3bv	83	37	and	and	CC
cord-001293-dfaxj3bv	83	38	opposing	oppose	VBG
cord-001293-dfaxj3bv	83	39	anti	anti	JJ
cord-001293-dfaxj3bv	83	40	-	-	JJ
cord-001293-dfaxj3bv	83	41	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	83	42	response(s	response(s	NN
cord-001293-dfaxj3bv	83	43	)	)	-RRB-
cord-001293-dfaxj3bv	83	44	occur	occur	VBP
cord-001293-dfaxj3bv	83	45	concomitantly	concomitantly	RB
cord-001293-dfaxj3bv	83	46	in	in	IN
cord-001293-dfaxj3bv	83	47	sepsis	sepsis	NN
cord-001293-dfaxj3bv	83	48	'	'	''
cord-001293-dfaxj3bv	83	49	[	[	-LRB-
cord-001293-dfaxj3bv	83	50	1	1	CD
cord-001293-dfaxj3bv	83	51	]	]	-RRB-
cord-001293-dfaxj3bv	83	52	.	.	.
cord-001293-dfaxj3bv	84	1	Tamayo	Tamayo	NNP
cord-001293-dfaxj3bv	84	2	and	and	CC
cord-001293-dfaxj3bv	84	3	colleagues	colleague	NNS
cord-001293-dfaxj3bv	84	4	[	[	-LRB-
cord-001293-dfaxj3bv	84	5	39	39	CD
cord-001293-dfaxj3bv	84	6	]	]	-RRB-
cord-001293-dfaxj3bv	84	7	studied	study	VBD
cord-001293-dfaxj3bv	84	8	a	a	DT
cord-001293-dfaxj3bv	84	9	large	large	JJ
cord-001293-dfaxj3bv	84	10	panel	panel	NN
cord-001293-dfaxj3bv	84	11	of	of	IN
cord-001293-dfaxj3bv	84	12	circulating	circulate	VBG
cord-001293-dfaxj3bv	84	13	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	84	14	in	in	IN
cord-001293-dfaxj3bv	84	15	patients	patient	NNS
cord-001293-dfaxj3bv	84	16	with	with	IN
cord-001293-dfaxj3bv	84	17	SIRS	SIRS	NNP
cord-001293-dfaxj3bv	84	18	or	or	CC
cord-001293-dfaxj3bv	84	19	sepsis	sepsis	NN
cord-001293-dfaxj3bv	84	20	,	,	,
cord-001293-dfaxj3bv	84	21	concluding	conclude	VBG
cord-001293-dfaxj3bv	84	22	that	that	IN
cord-001293-dfaxj3bv	84	23	both	both	CC
cord-001293-dfaxj3bv	84	24	pro	pro	JJ
cord-001293-dfaxj3bv	84	25	-	-	JJ
cord-001293-dfaxj3bv	84	26	and	and	CC
cord-001293-dfaxj3bv	84	27	anti	anti	JJ
cord-001293-dfaxj3bv	84	28	-	-	JJ
cord-001293-dfaxj3bv	84	29	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	84	30	mediators	mediator	NNS
cord-001293-dfaxj3bv	84	31	play	play	VBP
cord-001293-dfaxj3bv	84	32	roles	role	NNS
cord-001293-dfaxj3bv	84	33	from	from	IN
cord-001293-dfaxj3bv	84	34	the	the	DT
cord-001293-dfaxj3bv	84	35	very	very	JJ
cord-001293-dfaxj3bv	84	36	beginning	beginning	NN
cord-001293-dfaxj3bv	84	37	of	of	IN
cord-001293-dfaxj3bv	84	38	this	this	DT
cord-001293-dfaxj3bv	84	39	life	life	NN
cord-001293-dfaxj3bv	84	40	-	-	HYPH
cord-001293-dfaxj3bv	84	41	threatening	threaten	VBG
cord-001293-dfaxj3bv	84	42	condition	condition	NN
cord-001293-dfaxj3bv	84	43	.	.	.
cord-001293-dfaxj3bv	85	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	85	2	,	,	,
cord-001293-dfaxj3bv	85	3	meta	meta	NN
cord-001293-dfaxj3bv	85	4	-	-	HYPH
cord-001293-dfaxj3bv	85	5	analysis	analysis	NN
cord-001293-dfaxj3bv	85	6	of	of	IN
cord-001293-dfaxj3bv	85	7	12	12	CD
cord-001293-dfaxj3bv	85	8	transcriptomic	transcriptomic	JJ
cord-001293-dfaxj3bv	85	9	studies	study	NNS
cord-001293-dfaxj3bv	85	10	including	include	VBG
cord-001293-dfaxj3bv	85	11	784	784	CD
cord-001293-dfaxj3bv	85	12	individuals	individual	NNS
cord-001293-dfaxj3bv	85	13	led	lead	VBN
cord-001293-dfaxj3bv	85	14	to	to	IN
cord-001293-dfaxj3bv	85	15	the	the	DT
cord-001293-dfaxj3bv	85	16	conclusion	conclusion	NN
cord-001293-dfaxj3bv	85	17	that	that	IN
cord-001293-dfaxj3bv	85	18	'	'	``
cord-001293-dfaxj3bv	85	19	the	the	DT
cord-001293-dfaxj3bv	85	20	arbitrary	arbitrary	JJ
cord-001293-dfaxj3bv	85	21	distinction	distinction	NN
cord-001293-dfaxj3bv	85	22	of	of	IN
cord-001293-dfaxj3bv	85	23	separating	separate	VBG
cord-001293-dfaxj3bv	85	24	sepsis	sepsis	NN
cord-001293-dfaxj3bv	85	25	into	into	IN
cord-001293-dfaxj3bv	85	26	proinflammatory	proinflammatory	JJ
cord-001293-dfaxj3bv	85	27	and	and	CC
cord-001293-dfaxj3bv	85	28	anti	anti	JJ
cord-001293-dfaxj3bv	85	29	-	-	JJ
cord-001293-dfaxj3bv	85	30	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	85	31	phases	phase	NNS
cord-001293-dfaxj3bv	85	32	is	be	VBZ
cord-001293-dfaxj3bv	85	33	not	not	RB
cord-001293-dfaxj3bv	85	34	supported	support	VBN
cord-001293-dfaxj3bv	85	35	by	by	IN
cord-001293-dfaxj3bv	85	36	gene	gene	NN
cord-001293-dfaxj3bv	85	37	-	-	HYPH
cord-001293-dfaxj3bv	85	38	expression	expression	NN
cord-001293-dfaxj3bv	85	39	data	datum	NNS
cord-001293-dfaxj3bv	85	40	'	'	''
cord-001293-dfaxj3bv	85	41	[	[	-LRB-
cord-001293-dfaxj3bv	85	42	40	40	CD
cord-001293-dfaxj3bv	85	43	]	]	-RRB-
cord-001293-dfaxj3bv	85	44	.	.	.
cord-001293-dfaxj3bv	86	1	Immune	immune	JJ
cord-001293-dfaxj3bv	86	2	status	status	NN
cord-001293-dfaxj3bv	86	3	has	have	VBZ
cord-001293-dfaxj3bv	86	4	been	be	VBN
cord-001293-dfaxj3bv	86	5	studied	study	VBN
cord-001293-dfaxj3bv	86	6	frequently	frequently	RB
cord-001293-dfaxj3bv	86	7	by	by	IN
cord-001293-dfaxj3bv	86	8	measuring	measure	VBG
cord-001293-dfaxj3bv	86	9	TNF	TNF	NNP
cord-001293-dfaxj3bv	86	10	or	or	CC
cord-001293-dfaxj3bv	86	11	other	other	JJ
cord-001293-dfaxj3bv	86	12	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	86	13	cytokine	cytokine	NN
cord-001293-dfaxj3bv	86	14	production	production	NN
cord-001293-dfaxj3bv	86	15	by	by	IN
cord-001293-dfaxj3bv	86	16	circulating	circulate	VBG
cord-001293-dfaxj3bv	86	17	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	86	18	in	in	IN
cord-001293-dfaxj3bv	86	19	response	response	NN
cord-001293-dfaxj3bv	86	20	to	to	IN
cord-001293-dfaxj3bv	86	21	LPS	LPS	NNP
cord-001293-dfaxj3bv	86	22	[	[	-LRB-
cord-001293-dfaxj3bv	86	23	41	41	CD
cord-001293-dfaxj3bv	86	24	]	]	-RRB-
cord-001293-dfaxj3bv	86	25	.	.	.
cord-001293-dfaxj3bv	87	1	We	-PRON-	PRP
cord-001293-dfaxj3bv	87	2	studied	study	VBD
cord-001293-dfaxj3bv	87	3	patients	patient	NNS
cord-001293-dfaxj3bv	87	4	undergoing	undergo	VBG
cord-001293-dfaxj3bv	87	5	abdominal	abdominal	JJ
cord-001293-dfaxj3bv	87	6	aortic	aortic	JJ
cord-001293-dfaxj3bv	87	7	surgery	surgery	NN
cord-001293-dfaxj3bv	87	8	,	,	,
cord-001293-dfaxj3bv	87	9	showing	show	VBG
cord-001293-dfaxj3bv	87	10	that	that	IN
cord-001293-dfaxj3bv	87	11	reduced	reduce	VBN
cord-001293-dfaxj3bv	87	12	expression	expression	NN
cord-001293-dfaxj3bv	87	13	of	of	IN
cord-001293-dfaxj3bv	87	14	human	human	JJ
cord-001293-dfaxj3bv	87	15	leukocyte	leukocyte	NN
cord-001293-dfaxj3bv	87	16	antigen	antigen	NN
cord-001293-dfaxj3bv	87	17	(	(	-LRB-
cord-001293-dfaxj3bv	87	18	HLA)-DR	HLA)-DR	NNP
cord-001293-dfaxj3bv	87	19	on	on	IN
cord-001293-dfaxj3bv	87	20	CD14	CD14	NNP
cord-001293-dfaxj3bv	87	21	HIGH	high	JJ
cord-001293-dfaxj3bv	87	22	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	87	23	occurs	occur	VBZ
cord-001293-dfaxj3bv	87	24	during	during	IN
cord-001293-dfaxj3bv	87	25	surgery	surgery	NN
cord-001293-dfaxj3bv	87	26	[	[	-LRB-
cord-001293-dfaxj3bv	87	27	42	42	CD
cord-001293-dfaxj3bv	87	28	]	]	-RRB-
cord-001293-dfaxj3bv	87	29	.	.	.
cord-001293-dfaxj3bv	88	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	88	2	,	,	,
cord-001293-dfaxj3bv	88	3	HLA	HLA	NNP
cord-001293-dfaxj3bv	88	4	-	-	HYPH
cord-001293-dfaxj3bv	88	5	DR	DR	NNP
cord-001293-dfaxj3bv	88	6	expression	expression	NN
cord-001293-dfaxj3bv	88	7	was	be	VBD
cord-001293-dfaxj3bv	88	8	already	already	RB
cord-001293-dfaxj3bv	88	9	reduced	reduce	VBN
cord-001293-dfaxj3bv	88	10	on	on	IN
cord-001293-dfaxj3bv	88	11	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	88	12	taken	take	VBN
cord-001293-dfaxj3bv	88	13	very	very	RB
cord-001293-dfaxj3bv	88	14	soon	soon	RB
cord-001293-dfaxj3bv	88	15	after	after	IN
cord-001293-dfaxj3bv	88	16	severe	severe	JJ
cord-001293-dfaxj3bv	88	17	trauma	trauma	NN
cord-001293-dfaxj3bv	88	18	at	at	IN
cord-001293-dfaxj3bv	88	19	accident	accident	NN
cord-001293-dfaxj3bv	88	20	scenes	scene	NNS
cord-001293-dfaxj3bv	88	21	[	[	-LRB-
cord-001293-dfaxj3bv	88	22	43	43	CD
cord-001293-dfaxj3bv	88	23	]	]	-RRB-
cord-001293-dfaxj3bv	88	24	.	.	.
cord-001293-dfaxj3bv	89	1	Altered	alter	VBN
cord-001293-dfaxj3bv	89	2	TNF	TNF	NNP
cord-001293-dfaxj3bv	89	3	production	production	NN
cord-001293-dfaxj3bv	89	4	capacity	capacity	NN
cord-001293-dfaxj3bv	89	5	of	of	IN
cord-001293-dfaxj3bv	89	6	circulating	circulate	VBG
cord-001293-dfaxj3bv	89	7	cells	cell	NNS
cord-001293-dfaxj3bv	89	8	in	in	IN
cord-001293-dfaxj3bv	89	9	response	response	NN
cord-001293-dfaxj3bv	89	10	to	to	IN
cord-001293-dfaxj3bv	89	11	TLR2	TLR2	NNP
cord-001293-dfaxj3bv	89	12	or	or	CC
cord-001293-dfaxj3bv	89	13	TLR4	TLR4	NNP
cord-001293-dfaxj3bv	89	14	agonists	agonist	NNS
cord-001293-dfaxj3bv	89	15	is	be	VBZ
cord-001293-dfaxj3bv	89	16	also	also	RB
cord-001293-dfaxj3bv	89	17	observed	observe	VBN
cord-001293-dfaxj3bv	89	18	very	very	RB
cord-001293-dfaxj3bv	89	19	soon	soon	RB
cord-001293-dfaxj3bv	89	20	after	after	IN
cord-001293-dfaxj3bv	89	21	injurious	injurious	JJ
cord-001293-dfaxj3bv	89	22	insults	insult	NNS
cord-001293-dfaxj3bv	89	23	,	,	,
cord-001293-dfaxj3bv	89	24	such	such	JJ
cord-001293-dfaxj3bv	89	25	as	as	IN
cord-001293-dfaxj3bv	89	26	on	on	IN
cord-001293-dfaxj3bv	89	27	admission	admission	NN
cord-001293-dfaxj3bv	89	28	of	of	IN
cord-001293-dfaxj3bv	89	29	patients	patient	NNS
cord-001293-dfaxj3bv	89	30	after	after	IN
cord-001293-dfaxj3bv	89	31	cardiac	cardiac	JJ
cord-001293-dfaxj3bv	89	32	arrest	arrest	NN
cord-001293-dfaxj3bv	89	33	[	[	-LRB-
cord-001293-dfaxj3bv	89	34	44	44	CD
cord-001293-dfaxj3bv	89	35	]	]	-RRB-
cord-001293-dfaxj3bv	89	36	.	.	.
cord-001293-dfaxj3bv	90	1	Even	even	RB
cord-001293-dfaxj3bv	90	2	if	if	IN
cord-001293-dfaxj3bv	90	3	soon	soon	RB
cord-001293-dfaxj3bv	90	4	after	after	IN
cord-001293-dfaxj3bv	90	5	the	the	DT
cord-001293-dfaxj3bv	90	6	initial	initial	JJ
cord-001293-dfaxj3bv	90	7	insult	insult	NN
cord-001293-dfaxj3bv	90	8	the	the	DT
cord-001293-dfaxj3bv	90	9	intensity	intensity	NN
cord-001293-dfaxj3bv	90	10	of	of	IN
cord-001293-dfaxj3bv	90	11	the	the	DT
cord-001293-dfaxj3bv	90	12	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	90	13	response	response	NN
cord-001293-dfaxj3bv	90	14	reaches	reach	VBZ
cord-001293-dfaxj3bv	90	15	its	-PRON-	PRP$
cord-001293-dfaxj3bv	90	16	peak	peak	NN
cord-001293-dfaxj3bv	90	17	,	,	,
cord-001293-dfaxj3bv	90	18	there	there	EX
cord-001293-dfaxj3bv	90	19	is	be	VBZ
cord-001293-dfaxj3bv	90	20	a	a	DT
cord-001293-dfaxj3bv	90	21	persistent	persistent	JJ
cord-001293-dfaxj3bv	90	22	inflammation	inflammation	NN
cord-001293-dfaxj3bv	90	23	associated	associate	VBN
cord-001293-dfaxj3bv	90	24	with	with	IN
cord-001293-dfaxj3bv	90	25	altered	altered	JJ
cord-001293-dfaxj3bv	90	26	immune	immune	JJ
cord-001293-dfaxj3bv	90	27	status	status	NN
cord-001293-dfaxj3bv	90	28	in	in	IN
cord-001293-dfaxj3bv	90	29	surviving	survive	VBG
cord-001293-dfaxj3bv	90	30	patients	patient	NNS
cord-001293-dfaxj3bv	90	31	[	[	-LRB-
cord-001293-dfaxj3bv	90	32	45	45	CD
cord-001293-dfaxj3bv	90	33	]	]	-RRB-
cord-001293-dfaxj3bv	90	34	.	.	.
cord-001293-dfaxj3bv	91	1	The	the	DT
cord-001293-dfaxj3bv	91	2	more	more	RBR
cord-001293-dfaxj3bv	91	3	severe	severe	JJ
cord-001293-dfaxj3bv	91	4	the	the	DT
cord-001293-dfaxj3bv	91	5	insult	insult	NN
cord-001293-dfaxj3bv	91	6	,	,	,
cord-001293-dfaxj3bv	91	7	the	the	DT
cord-001293-dfaxj3bv	91	8	more	more	RBR
cord-001293-dfaxj3bv	91	9	profound	profound	JJ
cord-001293-dfaxj3bv	91	10	is	be	VBZ
cord-001293-dfaxj3bv	91	11	the	the	DT
cord-001293-dfaxj3bv	91	12	alteration	alteration	NN
cord-001293-dfaxj3bv	91	13	and	and	CC
cord-001293-dfaxj3bv	91	14	the	the	DT
cord-001293-dfaxj3bv	91	15	more	more	JJR
cord-001293-dfaxj3bv	91	16	chance	chance	NN
cord-001293-dfaxj3bv	91	17	the	the	DT
cord-001293-dfaxj3bv	91	18	patients	patient	NNS
cord-001293-dfaxj3bv	91	19	have	have	VB
cord-001293-dfaxj3bv	91	20	to	to	TO
cord-001293-dfaxj3bv	91	21	develop	develop	VB
cord-001293-dfaxj3bv	91	22	adverse	adverse	JJ
cord-001293-dfaxj3bv	91	23	clinical	clinical	JJ
cord-001293-dfaxj3bv	91	24	outcome	outcome	NN
cord-001293-dfaxj3bv	91	25	.	.	.
cord-001293-dfaxj3bv	92	1	The	the	DT
cord-001293-dfaxj3bv	92	2	immune	immune	JJ
cord-001293-dfaxj3bv	92	3	status	status	NN
cord-001293-dfaxj3bv	92	4	of	of	IN
cord-001293-dfaxj3bv	92	5	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	92	6	during	during	IN
cord-001293-dfaxj3bv	92	7	sepsis	sepsis	NN
cord-001293-dfaxj3bv	92	8	and	and	CC
cord-001293-dfaxj3bv	92	9	SIRS	SIRS	NNP
cord-001293-dfaxj3bv	92	10	varies	vary	VBZ
cord-001293-dfaxj3bv	92	11	depending	depend	VBG
cord-001293-dfaxj3bv	92	12	on	on	IN
cord-001293-dfaxj3bv	92	13	the	the	DT
cord-001293-dfaxj3bv	92	14	compartment	compartment	NN
cord-001293-dfaxj3bv	92	15	in	in	IN
cord-001293-dfaxj3bv	92	16	which	which	WDT
cord-001293-dfaxj3bv	92	17	they	-PRON-	PRP
cord-001293-dfaxj3bv	92	18	reside	reside	VBP
cord-001293-dfaxj3bv	92	19	Terms	term	NNS
cord-001293-dfaxj3bv	92	20	such	such	JJ
cord-001293-dfaxj3bv	92	21	as	as	IN
cord-001293-dfaxj3bv	92	22	'	'	``
cord-001293-dfaxj3bv	92	23	immunoparalysis	immunoparalysis	NN
cord-001293-dfaxj3bv	92	24	,	,	,
cord-001293-dfaxj3bv	92	25	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	92	26	,	,	,
cord-001293-dfaxj3bv	92	27	and	and	CC
cord-001293-dfaxj3bv	92	28	anergy	anergy	NNP
cord-001293-dfaxj3bv	92	29	'	'	''
cord-001293-dfaxj3bv	92	30	are	be	VBP
cord-001293-dfaxj3bv	92	31	far	far	RB
cord-001293-dfaxj3bv	92	32	too	too	RB
cord-001293-dfaxj3bv	92	33	extreme	extreme	JJ
cord-001293-dfaxj3bv	92	34	to	to	TO
cord-001293-dfaxj3bv	92	35	describe	describe	VB
cord-001293-dfaxj3bv	92	36	the	the	DT
cord-001293-dfaxj3bv	92	37	immune	immune	JJ
cord-001293-dfaxj3bv	92	38	status	status	NN
cord-001293-dfaxj3bv	92	39	of	of	IN
cord-001293-dfaxj3bv	92	40	circulating	circulate	VBG
cord-001293-dfaxj3bv	92	41	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	92	42	in	in	IN
cord-001293-dfaxj3bv	92	43	patients	patient	NNS
cord-001293-dfaxj3bv	92	44	with	with	IN
cord-001293-dfaxj3bv	92	45	sepsis	sepsis	NN
cord-001293-dfaxj3bv	92	46	or	or	CC
cord-001293-dfaxj3bv	92	47	SIRS	sirs	NN
cord-001293-dfaxj3bv	92	48	.	.	.
cord-001293-dfaxj3bv	93	1	Altered	alter	VBN
cord-001293-dfaxj3bv	93	2	immune	immune	JJ
cord-001293-dfaxj3bv	93	3	status	status	NN
cord-001293-dfaxj3bv	93	4	of	of	IN
cord-001293-dfaxj3bv	93	5	circulating	circulate	VBG
cord-001293-dfaxj3bv	93	6	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	93	7	is	be	VBZ
cord-001293-dfaxj3bv	93	8	not	not	RB
cord-001293-dfaxj3bv	93	9	globally	globally	RB
cord-001293-dfaxj3bv	93	10	present	present	JJ
cord-001293-dfaxj3bv	93	11	.	.	.
cord-001293-dfaxj3bv	94	1	Indeed	indeed	RB
cord-001293-dfaxj3bv	94	2	,	,	,
cord-001293-dfaxj3bv	94	3	some	some	DT
cord-001293-dfaxj3bv	94	4	functions	function	NNS
cord-001293-dfaxj3bv	94	5	like	like	IN
cord-001293-dfaxj3bv	94	6	phagocytosis	phagocytosis	NN
cord-001293-dfaxj3bv	94	7	remain	remain	VBP
cord-001293-dfaxj3bv	94	8	unaltered	unaltered	JJ
cord-001293-dfaxj3bv	94	9	[	[	-LRB-
cord-001293-dfaxj3bv	94	10	46	46	CD
cord-001293-dfaxj3bv	94	11	]	]	-RRB-
cord-001293-dfaxj3bv	94	12	,	,	,
cord-001293-dfaxj3bv	94	13	and	and	CC
cord-001293-dfaxj3bv	94	14	ex	ex	FW
cord-001293-dfaxj3bv	94	15	vivo	vivo	NN
cord-001293-dfaxj3bv	94	16	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	94	17	production	production	NN
cord-001293-dfaxj3bv	94	18	in	in	IN
cord-001293-dfaxj3bv	94	19	response	response	NN
cord-001293-dfaxj3bv	94	20	to	to	IN
cord-001293-dfaxj3bv	94	21	heat	heat	NN
cord-001293-dfaxj3bv	94	22	-	-	HYPH
cord-001293-dfaxj3bv	94	23	killed	kill	VBN
cord-001293-dfaxj3bv	94	24	S.	S.	NNP
cord-001293-dfaxj3bv	94	25	aureus	aureus	NN
cord-001293-dfaxj3bv	94	26	(	(	-LRB-
cord-001293-dfaxj3bv	94	27	HKSA	HKSA	NNP
cord-001293-dfaxj3bv	94	28	)	)	-RRB-
cord-001293-dfaxj3bv	94	29	remains	remain	VBZ
cord-001293-dfaxj3bv	94	30	unchanged	unchanged	JJ
cord-001293-dfaxj3bv	94	31	in	in	IN
cord-001293-dfaxj3bv	94	32	patients	patient	NNS
cord-001293-dfaxj3bv	94	33	with	with	IN
cord-001293-dfaxj3bv	94	34	sepsis	sepsis	NN
cord-001293-dfaxj3bv	94	35	[	[	-LRB-
cord-001293-dfaxj3bv	94	36	47	47	CD
cord-001293-dfaxj3bv	94	37	]	]	-RRB-
cord-001293-dfaxj3bv	94	38	compared	compare	VBN
cord-001293-dfaxj3bv	94	39	with	with	IN
cord-001293-dfaxj3bv	94	40	healthy	healthy	JJ
cord-001293-dfaxj3bv	94	41	controls	control	NNS
cord-001293-dfaxj3bv	94	42	.	.	.
cord-001293-dfaxj3bv	95	1	This	this	DT
cord-001293-dfaxj3bv	95	2	is	be	VBZ
cord-001293-dfaxj3bv	95	3	in	in	IN
cord-001293-dfaxj3bv	95	4	full	full	JJ
cord-001293-dfaxj3bv	95	5	agreement	agreement	NN
cord-001293-dfaxj3bv	95	6	with	with	IN
cord-001293-dfaxj3bv	95	7	the	the	DT
cord-001293-dfaxj3bv	95	8	observation	observation	NN
cord-001293-dfaxj3bv	95	9	that	that	IN
cord-001293-dfaxj3bv	95	10	LPS	LPS	NNP
cord-001293-dfaxj3bv	95	11	primes	prime	VBZ
cord-001293-dfaxj3bv	95	12	HKSA	HKSA	NNP
cord-001293-dfaxj3bv	95	13	-	-	HYPH
cord-001293-dfaxj3bv	95	14	induced	induce	VBN
cord-001293-dfaxj3bv	95	15	TNF	TNF	NNP
cord-001293-dfaxj3bv	95	16	production	production	NN
cord-001293-dfaxj3bv	95	17	in	in	IN
cord-001293-dfaxj3bv	95	18	macrophage	macrophage	NN
cord-001293-dfaxj3bv	95	19	cell	cell	NN
cord-001293-dfaxj3bv	95	20	lines	line	NNS
cord-001293-dfaxj3bv	95	21	instead	instead	RB
cord-001293-dfaxj3bv	95	22	of	of	IN
cord-001293-dfaxj3bv	95	23	leading	lead	VBG
cord-001293-dfaxj3bv	95	24	to	to	IN
cord-001293-dfaxj3bv	95	25	cross	cross	NN
cord-001293-dfaxj3bv	95	26	-	-	NN
cord-001293-dfaxj3bv	95	27	tolerance	tolerance	NN
cord-001293-dfaxj3bv	95	28	[	[	-LRB-
cord-001293-dfaxj3bv	95	29	48	48	CD
cord-001293-dfaxj3bv	95	30	]	]	-RRB-
cord-001293-dfaxj3bv	95	31	.	.	.
cord-001293-dfaxj3bv	96	1	While	while	IN
cord-001293-dfaxj3bv	96	2	the	the	DT
cord-001293-dfaxj3bv	96	3	concept	concept	NN
cord-001293-dfaxj3bv	96	4	of	of	IN
cord-001293-dfaxj3bv	96	5	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	96	6	tolerance	tolerance	NN
cord-001293-dfaxj3bv	96	7	is	be	VBZ
cord-001293-dfaxj3bv	96	8	considered	consider	VBN
cord-001293-dfaxj3bv	96	9	to	to	TO
cord-001293-dfaxj3bv	96	10	partially	partially	RB
cord-001293-dfaxj3bv	96	11	mimic	mimic	VB
cord-001293-dfaxj3bv	96	12	the	the	DT
cord-001293-dfaxj3bv	96	13	alteration	alteration	NN
cord-001293-dfaxj3bv	96	14	of	of	IN
cord-001293-dfaxj3bv	96	15	immune	immune	JJ
cord-001293-dfaxj3bv	96	16	status	status	NN
cord-001293-dfaxj3bv	96	17	in	in	IN
cord-001293-dfaxj3bv	96	18	sepsis	sepsis	NN
cord-001293-dfaxj3bv	96	19	,	,	,
cord-001293-dfaxj3bv	96	20	it	-PRON-	PRP
cord-001293-dfaxj3bv	96	21	is	be	VBZ
cord-001293-dfaxj3bv	96	22	worth	worth	JJ
cord-001293-dfaxj3bv	96	23	mentioning	mention	VBG
cord-001293-dfaxj3bv	96	24	that	that	IN
cord-001293-dfaxj3bv	96	25	cross	cross	NN
cord-001293-dfaxj3bv	96	26	-	-	NN
cord-001293-dfaxj3bv	96	27	tolerance	tolerance	NN
cord-001293-dfaxj3bv	96	28	between	between	IN
cord-001293-dfaxj3bv	96	29	microbial	microbial	JJ
cord-001293-dfaxj3bv	96	30	agonists	agonist	NNS
cord-001293-dfaxj3bv	96	31	is	be	VBZ
cord-001293-dfaxj3bv	96	32	not	not	RB
cord-001293-dfaxj3bv	96	33	invariant	invariant	JJ
cord-001293-dfaxj3bv	96	34	.	.	.
cord-001293-dfaxj3bv	97	1	For	for	IN
cord-001293-dfaxj3bv	97	2	example	example	NN
cord-001293-dfaxj3bv	97	3	,	,	,
cord-001293-dfaxj3bv	97	4	Candida	Candida	NNP
cord-001293-dfaxj3bv	97	5	albicans	albican	NNS
cord-001293-dfaxj3bv	97	6	and	and	CC
cord-001293-dfaxj3bv	97	7	fungal	fungal	JJ
cord-001293-dfaxj3bv	97	8	cell	cell	NN
cord-001293-dfaxj3bv	97	9	wall	wall	NN
cord-001293-dfaxj3bv	97	10	β	β	NNP
cord-001293-dfaxj3bv	97	11	-	-	HYPH
cord-001293-dfaxj3bv	97	12	glucan	glucan	NNP
cord-001293-dfaxj3bv	97	13	also	also	RB
cord-001293-dfaxj3bv	97	14	prime	prime	JJ
cord-001293-dfaxj3bv	97	15	LPS	LPS	NNP
cord-001293-dfaxj3bv	97	16	-	-	HYPH
cord-001293-dfaxj3bv	97	17	induced	induce	VBN
cord-001293-dfaxj3bv	97	18	proinflammatory	proinflammatory	JJ
cord-001293-dfaxj3bv	97	19	cytokine	cytokine	NN
cord-001293-dfaxj3bv	97	20	production	production	NN
cord-001293-dfaxj3bv	97	21	[	[	-LRB-
cord-001293-dfaxj3bv	97	22	49	49	CD
cord-001293-dfaxj3bv	97	23	]	]	-RRB-
cord-001293-dfaxj3bv	97	24	.	.	.
cord-001293-dfaxj3bv	98	1	These	these	DT
cord-001293-dfaxj3bv	98	2	observations	observation	NNS
cord-001293-dfaxj3bv	98	3	led	lead	VBD
cord-001293-dfaxj3bv	98	4	us	-PRON-	PRP
cord-001293-dfaxj3bv	98	5	to	to	TO
cord-001293-dfaxj3bv	98	6	propose	propose	VB
cord-001293-dfaxj3bv	98	7	the	the	DT
cord-001293-dfaxj3bv	98	8	concept	concept	NN
cord-001293-dfaxj3bv	98	9	of	of	IN
cord-001293-dfaxj3bv	98	10	leukocyte	leukocyte	NN
cord-001293-dfaxj3bv	98	11	reprogramming	reprogramme	VBG
cord-001293-dfaxj3bv	98	12	[	[	-LRB-
cord-001293-dfaxj3bv	98	13	50	50	CD
cord-001293-dfaxj3bv	98	14	]	]	-RRB-
cord-001293-dfaxj3bv	98	15	to	to	TO
cord-001293-dfaxj3bv	98	16	explain	explain	VB
cord-001293-dfaxj3bv	98	17	the	the	DT
cord-001293-dfaxj3bv	98	18	fact	fact	NN
cord-001293-dfaxj3bv	98	19	that	that	IN
cord-001293-dfaxj3bv	98	20	tolerised	tolerise	VBN
cord-001293-dfaxj3bv	98	21	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	98	22	retain	retain	VBP
cord-001293-dfaxj3bv	98	23	anti	anti	JJ
cord-001293-dfaxj3bv	98	24	-	-	JJ
cord-001293-dfaxj3bv	98	25	infectious	infectious	JJ
cord-001293-dfaxj3bv	98	26	properties	property	NNS
cord-001293-dfaxj3bv	98	27	.	.	.
cord-001293-dfaxj3bv	99	1	In	in	IN
cord-001293-dfaxj3bv	99	2	addition	addition	NN
cord-001293-dfaxj3bv	99	3	,	,	,
cord-001293-dfaxj3bv	99	4	in	in	IN
cord-001293-dfaxj3bv	99	5	tissues	tissue	NNS
cord-001293-dfaxj3bv	99	6	,	,	,
cord-001293-dfaxj3bv	99	7	there	there	EX
cord-001293-dfaxj3bv	99	8	are	be	VBP
cord-001293-dfaxj3bv	99	9	numerous	numerous	JJ
cord-001293-dfaxj3bv	99	10	examples	example	NNS
cord-001293-dfaxj3bv	99	11	to	to	TO
cord-001293-dfaxj3bv	99	12	illustrate	illustrate	VB
cord-001293-dfaxj3bv	99	13	the	the	DT
cord-001293-dfaxj3bv	99	14	hyper	hyper	NN
cord-001293-dfaxj3bv	99	15	-	-	NN
cord-001293-dfaxj3bv	99	16	activity	activity	NN
cord-001293-dfaxj3bv	99	17	of	of	IN
cord-001293-dfaxj3bv	99	18	these	these	DT
cord-001293-dfaxj3bv	99	19	cells	cell	NNS
cord-001293-dfaxj3bv	99	20	.	.	.
cord-001293-dfaxj3bv	100	1	For	for	IN
cord-001293-dfaxj3bv	100	2	example	example	NN
cord-001293-dfaxj3bv	100	3	,	,	,
cord-001293-dfaxj3bv	100	4	in	in	IN
cord-001293-dfaxj3bv	100	5	mice	mouse	NNS
cord-001293-dfaxj3bv	100	6	with	with	IN
cord-001293-dfaxj3bv	100	7	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	100	8	sepsis	sepsis	NN
cord-001293-dfaxj3bv	100	9	alone	alone	RB
cord-001293-dfaxj3bv	100	10	or	or	CC
cord-001293-dfaxj3bv	100	11	as	as	IN
cord-001293-dfaxj3bv	100	12	a	a	DT
cord-001293-dfaxj3bv	100	13	'	'	``
cord-001293-dfaxj3bv	100	14	second	second	JJ
cord-001293-dfaxj3bv	100	15	hit	hit	NN
cord-001293-dfaxj3bv	100	16	'	'	''
cord-001293-dfaxj3bv	100	17	after	after	IN
cord-001293-dfaxj3bv	100	18	traumatic	traumatic	JJ
cord-001293-dfaxj3bv	100	19	hemorrhage	hemorrhage	NN
cord-001293-dfaxj3bv	100	20	,	,	,
cord-001293-dfaxj3bv	100	21	it	-PRON-	PRP
cord-001293-dfaxj3bv	100	22	was	be	VBD
cord-001293-dfaxj3bv	100	23	nicely	nicely	RB
cord-001293-dfaxj3bv	100	24	demonstrated	demonstrate	VBN
cord-001293-dfaxj3bv	100	25	by	by	IN
cord-001293-dfaxj3bv	100	26	Chaudry	Chaudry	NNP
cord-001293-dfaxj3bv	100	27	's	's	POS
cord-001293-dfaxj3bv	100	28	group	group	NN
cord-001293-dfaxj3bv	100	29	[	[	-LRB-
cord-001293-dfaxj3bv	100	30	51	51	CD
cord-001293-dfaxj3bv	100	31	]	]	-RRB-
cord-001293-dfaxj3bv	100	32	that	that	IN
cord-001293-dfaxj3bv	100	33	the	the	DT
cord-001293-dfaxj3bv	100	34	ex	ex	FW
cord-001293-dfaxj3bv	100	35	vivo	vivo	NN
cord-001293-dfaxj3bv	100	36	production	production	NN
cord-001293-dfaxj3bv	100	37	of	of	IN
cord-001293-dfaxj3bv	100	38	TNF	TNF	NNP
cord-001293-dfaxj3bv	100	39	or	or	CC
cord-001293-dfaxj3bv	100	40	IL-6	IL-6	NNP
cord-001293-dfaxj3bv	100	41	after	after	IN
cord-001293-dfaxj3bv	100	42	LPS	LPS	NNP
cord-001293-dfaxj3bv	100	43	activation	activation	NN
cord-001293-dfaxj3bv	100	44	was	be	VBD
cord-001293-dfaxj3bv	100	45	significantly	significantly	RB
cord-001293-dfaxj3bv	100	46	reduced	reduce	VBN
cord-001293-dfaxj3bv	100	47	among	among	IN
cord-001293-dfaxj3bv	100	48	peripheral	peripheral	JJ
cord-001293-dfaxj3bv	100	49	blood	blood	NN
cord-001293-dfaxj3bv	100	50	mononuclear	mononuclear	NN
cord-001293-dfaxj3bv	100	51	cells	cell	NNS
cord-001293-dfaxj3bv	100	52	and	and	CC
cord-001293-dfaxj3bv	100	53	splenic	splenic	JJ
cord-001293-dfaxj3bv	100	54	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	100	55	but	but	CC
cord-001293-dfaxj3bv	100	56	that	that	IN
cord-001293-dfaxj3bv	100	57	it	-PRON-	PRP
cord-001293-dfaxj3bv	100	58	was	be	VBD
cord-001293-dfaxj3bv	100	59	enhanced	enhance	VBN
cord-001293-dfaxj3bv	100	60	in	in	IN
cord-001293-dfaxj3bv	100	61	alveolar	alveolar	NN
cord-001293-dfaxj3bv	100	62	and	and	CC
cord-001293-dfaxj3bv	100	63	Kupffer	Kupffer	NNP
cord-001293-dfaxj3bv	100	64	cells	cell	NNS
cord-001293-dfaxj3bv	100	65	.	.	.
cord-001293-dfaxj3bv	101	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	101	2	,	,	,
cord-001293-dfaxj3bv	101	3	in	in	IN
cord-001293-dfaxj3bv	101	4	a	a	DT
cord-001293-dfaxj3bv	101	5	murine	murine	JJ
cord-001293-dfaxj3bv	101	6	model	model	NN
cord-001293-dfaxj3bv	101	7	of	of	IN
cord-001293-dfaxj3bv	101	8	trauma	trauma	NN
cord-001293-dfaxj3bv	101	9	,	,	,
cord-001293-dfaxj3bv	101	10	the	the	DT
cord-001293-dfaxj3bv	101	11	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	101	12	productive	productive	JJ
cord-001293-dfaxj3bv	101	13	capacity	capacity	NN
cord-001293-dfaxj3bv	101	14	of	of	IN
cord-001293-dfaxj3bv	101	15	Kupffer	Kupffer	NNP
cord-001293-dfaxj3bv	101	16	cells	cell	NNS
cord-001293-dfaxj3bv	101	17	and	and	CC
cord-001293-dfaxj3bv	101	18	alveolar	alveolar	JJ
cord-001293-dfaxj3bv	101	19	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	101	20	was	be	VBD
cord-001293-dfaxj3bv	101	21	enhanced	enhance	VBN
cord-001293-dfaxj3bv	101	22	[	[	-LRB-
cord-001293-dfaxj3bv	101	23	52	52	CD
cord-001293-dfaxj3bv	101	24	]	]	-RRB-
cord-001293-dfaxj3bv	101	25	.	.	.
cord-001293-dfaxj3bv	102	1	Indeed	indeed	RB
cord-001293-dfaxj3bv	102	2	,	,	,
cord-001293-dfaxj3bv	102	3	macrophage	macrophage	NN
cord-001293-dfaxj3bv	102	4	functions	function	NNS
cord-001293-dfaxj3bv	102	5	differ	differ	VBP
cord-001293-dfaxj3bv	102	6	depending	depend	VBG
cord-001293-dfaxj3bv	102	7	on	on	IN
cord-001293-dfaxj3bv	102	8	the	the	DT
cord-001293-dfaxj3bv	102	9	compartment	compartment	NN
cord-001293-dfaxj3bv	102	10	from	from	IN
cord-001293-dfaxj3bv	102	11	which	which	WDT
cord-001293-dfaxj3bv	102	12	they	-PRON-	PRP
cord-001293-dfaxj3bv	102	13	derive	derive	VBP
cord-001293-dfaxj3bv	102	14	.	.	.
cord-001293-dfaxj3bv	103	1	We	-PRON-	PRP
cord-001293-dfaxj3bv	103	2	established	establish	VBD
cord-001293-dfaxj3bv	103	3	[	[	-LRB-
cord-001293-dfaxj3bv	103	4	53	53	CD
cord-001293-dfaxj3bv	103	5	]	]	-RRB-
cord-001293-dfaxj3bv	103	6	that	that	IN
cord-001293-dfaxj3bv	103	7	the	the	DT
cord-001293-dfaxj3bv	103	8	specific	specific	JJ
cord-001293-dfaxj3bv	103	9	cytokine	cytokine	NN
cord-001293-dfaxj3bv	103	10	and	and	CC
cord-001293-dfaxj3bv	103	11	cellular	cellular	JJ
cord-001293-dfaxj3bv	103	12	microenvironment	microenvironment	NN
cord-001293-dfaxj3bv	103	13	within	within	IN
cord-001293-dfaxj3bv	103	14	the	the	DT
cord-001293-dfaxj3bv	103	15	lung	lung	NN
cord-001293-dfaxj3bv	103	16	was	be	VBD
cord-001293-dfaxj3bv	103	17	responsible	responsible	JJ
cord-001293-dfaxj3bv	103	18	for	for	IN
cord-001293-dfaxj3bv	103	19	this	this	DT
cord-001293-dfaxj3bv	103	20	particular	particular	JJ
cord-001293-dfaxj3bv	103	21	resistance	resistance	NN
cord-001293-dfaxj3bv	103	22	of	of	IN
cord-001293-dfaxj3bv	103	23	alveolar	alveolar	JJ
cord-001293-dfaxj3bv	103	24	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	103	25	to	to	TO
cord-001293-dfaxj3bv	103	26	endotoxin	endotoxin	VB
cord-001293-dfaxj3bv	103	27	tolerance	tolerance	NN
cord-001293-dfaxj3bv	103	28	,	,	,
cord-001293-dfaxj3bv	103	29	which	which	WDT
cord-001293-dfaxj3bv	103	30	can	can	MD
cord-001293-dfaxj3bv	103	31	also	also	RB
cord-001293-dfaxj3bv	103	32	be	be	VB
cord-001293-dfaxj3bv	103	33	observed	observe	VBN
cord-001293-dfaxj3bv	103	34	in	in	IN
cord-001293-dfaxj3bv	103	35	human	human	JJ
cord-001293-dfaxj3bv	103	36	alveolar	alveolar	NN
cord-001293-dfaxj3bv	103	37	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	103	38	[	[	-LRB-
cord-001293-dfaxj3bv	103	39	54	54	CD
cord-001293-dfaxj3bv	103	40	]	]	-RRB-
cord-001293-dfaxj3bv	103	41	.	.	.
cord-001293-dfaxj3bv	104	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	104	2	,	,	,
cord-001293-dfaxj3bv	104	3	in	in	IN
cord-001293-dfaxj3bv	104	4	kidneys	kidney	NNS
cord-001293-dfaxj3bv	104	5	,	,	,
cord-001293-dfaxj3bv	104	6	in	in	IN
cord-001293-dfaxj3bv	104	7	response	response	NN
cord-001293-dfaxj3bv	104	8	to	to	IN
cord-001293-dfaxj3bv	104	9	a	a	DT
cord-001293-dfaxj3bv	104	10	second	second	JJ
cord-001293-dfaxj3bv	104	11	challenge	challenge	NN
cord-001293-dfaxj3bv	104	12	with	with	IN
cord-001293-dfaxj3bv	104	13	LPS	LPS	NNP
cord-001293-dfaxj3bv	104	14	,	,	,
cord-001293-dfaxj3bv	104	15	the	the	DT
cord-001293-dfaxj3bv	104	16	expression	expression	NN
cord-001293-dfaxj3bv	104	17	of	of	IN
cord-001293-dfaxj3bv	104	18	TNF	TNF	NNP
cord-001293-dfaxj3bv	104	19	and	and	CC
cord-001293-dfaxj3bv	104	20	inducible	inducible	JJ
cord-001293-dfaxj3bv	104	21	nitric	nitric	NN
cord-001293-dfaxj3bv	104	22	oxide	oxide	NN
cord-001293-dfaxj3bv	104	23	synthase	synthase	NN
cord-001293-dfaxj3bv	104	24	was	be	VBD
cord-001293-dfaxj3bv	104	25	further	further	RB
cord-001293-dfaxj3bv	104	26	enhanced	enhance	VBN
cord-001293-dfaxj3bv	104	27	[	[	-LRB-
cord-001293-dfaxj3bv	104	28	55	55	CD
cord-001293-dfaxj3bv	104	29	]	]	-RRB-
cord-001293-dfaxj3bv	104	30	.	.	.
cord-001293-dfaxj3bv	105	1	This	this	DT
cord-001293-dfaxj3bv	105	2	may	may	MD
cord-001293-dfaxj3bv	105	3	explain	explain	VB
cord-001293-dfaxj3bv	105	4	why	why	WRB
cord-001293-dfaxj3bv	105	5	unilateral	unilateral	JJ
cord-001293-dfaxj3bv	105	6	nephrectomy	nephrectomy	NN
cord-001293-dfaxj3bv	105	7	could	could	MD
cord-001293-dfaxj3bv	105	8	be	be	VB
cord-001293-dfaxj3bv	105	9	protective	protective	JJ
cord-001293-dfaxj3bv	105	10	in	in	IN
cord-001293-dfaxj3bv	105	11	a	a	DT
cord-001293-dfaxj3bv	105	12	murine	murine	JJ
cord-001293-dfaxj3bv	105	13	peritonitis	peritonitis	NN
cord-001293-dfaxj3bv	105	14	model	model	NN
cord-001293-dfaxj3bv	105	15	and	and	CC
cord-001293-dfaxj3bv	105	16	after	after	IN
cord-001293-dfaxj3bv	105	17	LPS	LPS	NNP
cord-001293-dfaxj3bv	105	18	injection	injection	NN
cord-001293-dfaxj3bv	105	19	[	[	-LRB-
cord-001293-dfaxj3bv	105	20	56	56	CD
cord-001293-dfaxj3bv	105	21	]	]	-RRB-
cord-001293-dfaxj3bv	105	22	.	.	.
cord-001293-dfaxj3bv	106	1	Most	most	RBS
cord-001293-dfaxj3bv	106	2	importantly	importantly	RB
cord-001293-dfaxj3bv	106	3	,	,	,
cord-001293-dfaxj3bv	106	4	despite	despite	IN
cord-001293-dfaxj3bv	106	5	the	the	DT
cord-001293-dfaxj3bv	106	6	fashionable	fashionable	JJ
cord-001293-dfaxj3bv	106	7	concept	concept	NN
cord-001293-dfaxj3bv	106	8	of	of	IN
cord-001293-dfaxj3bv	106	9	M1	M1	NNP
cord-001293-dfaxj3bv	106	10	/	/	SYM
cord-001293-dfaxj3bv	106	11	M2	M2	NNP
cord-001293-dfaxj3bv	106	12	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	106	13	,	,	,
cord-001293-dfaxj3bv	106	14	the	the	DT
cord-001293-dfaxj3bv	106	15	response	response	NN
cord-001293-dfaxj3bv	106	16	of	of	IN
cord-001293-dfaxj3bv	106	17	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	106	18	to	to	IN
cord-001293-dfaxj3bv	106	19	IL-4	IL-4	NNP
cord-001293-dfaxj3bv	106	20	and	and	CC
cord-001293-dfaxj3bv	106	21	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	106	22	is	be	VBZ
cord-001293-dfaxj3bv	106	23	in	in	IN
cord-001293-dfaxj3bv	106	24	fact	fact	NN
cord-001293-dfaxj3bv	106	25	completely	completely	RB
cord-001293-dfaxj3bv	106	26	different	different	JJ
cord-001293-dfaxj3bv	106	27	depending	depend	VBG
cord-001293-dfaxj3bv	106	28	upon	upon	IN
cord-001293-dfaxj3bv	106	29	their	-PRON-	PRP$
cord-001293-dfaxj3bv	106	30	origin	origin	NN
cord-001293-dfaxj3bv	106	31	[	[	-LRB-
cord-001293-dfaxj3bv	106	32	57	57	CD
cord-001293-dfaxj3bv	106	33	]	]	-RRB-
cord-001293-dfaxj3bv	106	34	.	.	.
cord-001293-dfaxj3bv	107	1	As	as	IN
cord-001293-dfaxj3bv	107	2	a	a	DT
cord-001293-dfaxj3bv	107	3	consequence	consequence	NN
cord-001293-dfaxj3bv	107	4	of	of	IN
cord-001293-dfaxj3bv	107	5	this	this	DT
cord-001293-dfaxj3bv	107	6	great	great	JJ
cord-001293-dfaxj3bv	107	7	heterogeneity	heterogeneity	NN
cord-001293-dfaxj3bv	107	8	of	of	IN
cord-001293-dfaxj3bv	107	9	immune	immune	JJ
cord-001293-dfaxj3bv	107	10	cells	cell	NNS
cord-001293-dfaxj3bv	107	11	within	within	IN
cord-001293-dfaxj3bv	107	12	different	different	JJ
cord-001293-dfaxj3bv	107	13	compartments	compartment	NNS
cord-001293-dfaxj3bv	107	14	,	,	,
cord-001293-dfaxj3bv	107	15	each	each	DT
cord-001293-dfaxj3bv	107	16	tissue	tissue	NN
cord-001293-dfaxj3bv	107	17	behaves	behave	VBZ
cord-001293-dfaxj3bv	107	18	independently	independently	RB
cord-001293-dfaxj3bv	107	19	,	,	,
cord-001293-dfaxj3bv	107	20	contributing	contribute	VBG
cord-001293-dfaxj3bv	107	21	to	to	IN
cord-001293-dfaxj3bv	107	22	the	the	DT
cord-001293-dfaxj3bv	107	23	global	global	JJ
cord-001293-dfaxj3bv	107	24	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	107	25	response	response	NN
cord-001293-dfaxj3bv	107	26	with	with	IN
cord-001293-dfaxj3bv	107	27	a	a	DT
cord-001293-dfaxj3bv	107	28	specific	specific	JJ
cord-001293-dfaxj3bv	107	29	pattern	pattern	NN
cord-001293-dfaxj3bv	107	30	,	,	,
cord-001293-dfaxj3bv	107	31	as	as	IN
cord-001293-dfaxj3bv	107	32	illustrated	illustrate	VBN
cord-001293-dfaxj3bv	107	33	by	by	IN
cord-001293-dfaxj3bv	107	34	differential	differential	JJ
cord-001293-dfaxj3bv	107	35	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	107	36	expression	expression	NN
cord-001293-dfaxj3bv	107	37	in	in	IN
cord-001293-dfaxj3bv	107	38	liver	liver	NN
cord-001293-dfaxj3bv	107	39	,	,	,
cord-001293-dfaxj3bv	107	40	lungs	lung	NNS
cord-001293-dfaxj3bv	107	41	,	,	,
cord-001293-dfaxj3bv	107	42	heart	heart	NN
cord-001293-dfaxj3bv	107	43	,	,	,
cord-001293-dfaxj3bv	107	44	brain	brain	NN
cord-001293-dfaxj3bv	107	45	,	,	,
cord-001293-dfaxj3bv	107	46	muscle	muscle	NN
cord-001293-dfaxj3bv	107	47	,	,	,
cord-001293-dfaxj3bv	107	48	kidney	kidney	NN
cord-001293-dfaxj3bv	107	49	,	,	,
cord-001293-dfaxj3bv	107	50	intestine	intestine	NN
cord-001293-dfaxj3bv	107	51	,	,	,
cord-001293-dfaxj3bv	107	52	and	and	CC
cord-001293-dfaxj3bv	107	53	spleen	spleen	NNS
cord-001293-dfaxj3bv	107	54	[	[	-LRB-
cord-001293-dfaxj3bv	107	55	58	58	CD
cord-001293-dfaxj3bv	107	56	]	]	-RRB-
cord-001293-dfaxj3bv	107	57	.	.	.
cord-001293-dfaxj3bv	108	1	Another	another	DT
cord-001293-dfaxj3bv	108	2	example	example	NN
cord-001293-dfaxj3bv	108	3	of	of	IN
cord-001293-dfaxj3bv	108	4	the	the	DT
cord-001293-dfaxj3bv	108	5	different	different	JJ
cord-001293-dfaxj3bv	108	6	behavior	behavior	NN
cord-001293-dfaxj3bv	108	7	of	of	IN
cord-001293-dfaxj3bv	108	8	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	108	9	in	in	IN
cord-001293-dfaxj3bv	108	10	various	various	JJ
cord-001293-dfaxj3bv	108	11	compartments	compartment	NNS
cord-001293-dfaxj3bv	108	12	is	be	VBZ
cord-001293-dfaxj3bv	108	13	the	the	DT
cord-001293-dfaxj3bv	108	14	frequent	frequent	JJ
cord-001293-dfaxj3bv	108	15	occurrence	occurrence	NN
cord-001293-dfaxj3bv	108	16	of	of	IN
cord-001293-dfaxj3bv	108	17	hemophagocytosis	hemophagocytosis	NN
cord-001293-dfaxj3bv	108	18	(	(	-LRB-
cord-001293-dfaxj3bv	108	19	>	>	NFP
cord-001293-dfaxj3bv	108	20	60	60	CD
cord-001293-dfaxj3bv	108	21	%	%	NN
cord-001293-dfaxj3bv	108	22	)	)	-RRB-
cord-001293-dfaxj3bv	108	23	directly	directly	RB
cord-001293-dfaxj3bv	108	24	observed	observe	VBN
cord-001293-dfaxj3bv	108	25	in	in	IN
cord-001293-dfaxj3bv	108	26	the	the	DT
cord-001293-dfaxj3bv	108	27	bone	bone	NN
cord-001293-dfaxj3bv	108	28	marrow	marrow	NN
cord-001293-dfaxj3bv	108	29	of	of	IN
cord-001293-dfaxj3bv	108	30	the	the	DT
cord-001293-dfaxj3bv	108	31	critically	critically	RB
cord-001293-dfaxj3bv	108	32	ill	ill	JJ
cord-001293-dfaxj3bv	108	33	[	[	-LRB-
cord-001293-dfaxj3bv	108	34	59	59	CD
cord-001293-dfaxj3bv	108	35	]	]	-RRB-
cord-001293-dfaxj3bv	108	36	.	.	.
cord-001293-dfaxj3bv	109	1	This	this	DT
cord-001293-dfaxj3bv	109	2	phenomenon	phenomenon	NN
cord-001293-dfaxj3bv	109	3	is	be	VBZ
cord-001293-dfaxj3bv	109	4	associated	associate	VBN
cord-001293-dfaxj3bv	109	5	with	with	IN
cord-001293-dfaxj3bv	109	6	extreme	extreme	JJ
cord-001293-dfaxj3bv	109	7	production	production	NN
cord-001293-dfaxj3bv	109	8	of	of	IN
cord-001293-dfaxj3bv	109	9	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	109	10	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	109	11	.	.	.
cord-001293-dfaxj3bv	110	1	Accordingly	accordingly	RB
cord-001293-dfaxj3bv	110	2	,	,	,
cord-001293-dfaxj3bv	110	3	it	-PRON-	PRP
cord-001293-dfaxj3bv	110	4	has	have	VBZ
cord-001293-dfaxj3bv	110	5	been	be	VBN
cord-001293-dfaxj3bv	110	6	proposed	propose	VBN
cord-001293-dfaxj3bv	110	7	that	that	IN
cord-001293-dfaxj3bv	110	8	when	when	WRB
cord-001293-dfaxj3bv	110	9	hemophagocytosis	hemophagocytosis	NNP
cord-001293-dfaxj3bv	110	10	is	be	VBZ
cord-001293-dfaxj3bv	110	11	diagnosed	diagnose	VBN
cord-001293-dfaxj3bv	110	12	in	in	IN
cord-001293-dfaxj3bv	110	13	critical	critical	JJ
cord-001293-dfaxj3bv	110	14	care	care	NN
cord-001293-dfaxj3bv	110	15	patients	patient	NNS
cord-001293-dfaxj3bv	110	16	,	,	,
cord-001293-dfaxj3bv	110	17	aggressive	aggressive	JJ
cord-001293-dfaxj3bv	110	18	immunosuppressive	immunosuppressive	JJ
cord-001293-dfaxj3bv	110	19	therapy	therapy	NN
cord-001293-dfaxj3bv	110	20	be	be	VB
cord-001293-dfaxj3bv	110	21	undertaken	undertake	VBN
cord-001293-dfaxj3bv	110	22	without	without	IN
cord-001293-dfaxj3bv	110	23	delay	delay	NN
cord-001293-dfaxj3bv	110	24	[	[	-LRB-
cord-001293-dfaxj3bv	110	25	59	59	CD
cord-001293-dfaxj3bv	110	26	]	]	-RRB-
cord-001293-dfaxj3bv	110	27	.	.	.
cord-001293-dfaxj3bv	111	1	Differences	difference	NNS
cord-001293-dfaxj3bv	111	2	between	between	IN
cord-001293-dfaxj3bv	111	3	cells	cell	NNS
cord-001293-dfaxj3bv	111	4	harvested	harvest	VBN
cord-001293-dfaxj3bv	111	5	from	from	IN
cord-001293-dfaxj3bv	111	6	different	different	JJ
cord-001293-dfaxj3bv	111	7	compartments	compartment	NNS
cord-001293-dfaxj3bv	111	8	after	after	IN
cord-001293-dfaxj3bv	111	9	sepsis	sepsis	NN
cord-001293-dfaxj3bv	111	10	have	have	VBP
cord-001293-dfaxj3bv	111	11	also	also	RB
cord-001293-dfaxj3bv	111	12	been	be	VBN
cord-001293-dfaxj3bv	111	13	reported	report	VBN
cord-001293-dfaxj3bv	111	14	for	for	IN
cord-001293-dfaxj3bv	111	15	spleen	spleen	NNS
cord-001293-dfaxj3bv	111	16	and	and	CC
cord-001293-dfaxj3bv	111	17	peritoneal	peritoneal	JJ
cord-001293-dfaxj3bv	111	18	myeloid	myeloid	NN
cord-001293-dfaxj3bv	111	19	DCs	dc	NNS
cord-001293-dfaxj3bv	111	20	[	[	-LRB-
cord-001293-dfaxj3bv	111	21	60	60	CD
cord-001293-dfaxj3bv	111	22	]	]	-RRB-
cord-001293-dfaxj3bv	111	23	.	.	.
cord-001293-dfaxj3bv	112	1	The	the	DT
cord-001293-dfaxj3bv	112	2	major	major	JJ
cord-001293-dfaxj3bv	112	3	differences	difference	NNS
cord-001293-dfaxj3bv	112	4	between	between	IN
cord-001293-dfaxj3bv	112	5	compartments	compartment	NNS
cord-001293-dfaxj3bv	112	6	are	be	VBP
cord-001293-dfaxj3bv	112	7	further	far	RBR
cord-001293-dfaxj3bv	112	8	illustrated	illustrate	VBN
cord-001293-dfaxj3bv	112	9	by	by	IN
cord-001293-dfaxj3bv	112	10	the	the	DT
cord-001293-dfaxj3bv	112	11	fact	fact	NN
cord-001293-dfaxj3bv	112	12	that	that	IN
cord-001293-dfaxj3bv	112	13	gene	gene	NN
cord-001293-dfaxj3bv	112	14	deficiency	deficiency	NN
cord-001293-dfaxj3bv	112	15	may	may	MD
cord-001293-dfaxj3bv	112	16	differentially	differentially	RB
cord-001293-dfaxj3bv	112	17	affect	affect	VB
cord-001293-dfaxj3bv	112	18	outcomes	outcome	NNS
cord-001293-dfaxj3bv	112	19	of	of	IN
cord-001293-dfaxj3bv	112	20	infection	infection	NN
cord-001293-dfaxj3bv	112	21	.	.	.
cord-001293-dfaxj3bv	113	1	For	for	IN
cord-001293-dfaxj3bv	113	2	example	example	NN
cord-001293-dfaxj3bv	113	3	,	,	,
cord-001293-dfaxj3bv	113	4	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	113	5	deficiency	deficiency	NN
cord-001293-dfaxj3bv	113	6	protects	protect	VBZ
cord-001293-dfaxj3bv	113	7	against	against	IN
cord-001293-dfaxj3bv	113	8	Francisella	Francisella	NNP
cord-001293-dfaxj3bv	113	9	tularensis	tularensis	NNP
cord-001293-dfaxj3bv	113	10	pulmonary	pulmonary	JJ
cord-001293-dfaxj3bv	113	11	infection	infection	NN
cord-001293-dfaxj3bv	113	12	but	but	CC
cord-001293-dfaxj3bv	113	13	aggravates	aggravate	VBZ
cord-001293-dfaxj3bv	113	14	cutaneous	cutaneous	JJ
cord-001293-dfaxj3bv	113	15	infection	infection	NN
cord-001293-dfaxj3bv	113	16	[	[	-LRB-
cord-001293-dfaxj3bv	113	17	61	61	CD
cord-001293-dfaxj3bv	113	18	]	]	-RRB-
cord-001293-dfaxj3bv	113	19	.	.	.
cord-001293-dfaxj3bv	114	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	114	2	,	,	,
cord-001293-dfaxj3bv	114	3	we	-PRON-	PRP
cord-001293-dfaxj3bv	114	4	showed	show	VBD
cord-001293-dfaxj3bv	114	5	that	that	IN
cord-001293-dfaxj3bv	114	6	scavenger	scavenger	NN
cord-001293-dfaxj3bv	114	7	receptor	receptor	NN
cord-001293-dfaxj3bv	114	8	-	-	:
cord-001293-dfaxj3bv	114	9	A	a	NN
cord-001293-dfaxj3bv	114	10	(	(	-LRB-
cord-001293-dfaxj3bv	114	11	SR	SR	NNP
cord-001293-dfaxj3bv	114	12	-	-	HYPH
cord-001293-dfaxj3bv	114	13	A	A	NNP
cord-001293-dfaxj3bv	114	14	)	)	-RRB-
cord-001293-dfaxj3bv	114	15	,	,	,
cord-001293-dfaxj3bv	114	16	'	'	''
cord-001293-dfaxj3bv	114	17	macrophage	macrophage	NN
cord-001293-dfaxj3bv	114	18	associated	associate	VBN
cord-001293-dfaxj3bv	114	19	receptor	receptor	NN
cord-001293-dfaxj3bv	114	20	with	with	IN
cord-001293-dfaxj3bv	114	21	a	a	DT
cord-001293-dfaxj3bv	114	22	collagenous	collagenous	JJ
cord-001293-dfaxj3bv	114	23	base	base	NN
cord-001293-dfaxj3bv	114	24	'	'	''
cord-001293-dfaxj3bv	114	25	(	(	-LRB-
cord-001293-dfaxj3bv	114	26	MARCO	MARCO	NNP
cord-001293-dfaxj3bv	114	27	)	)	-RRB-
cord-001293-dfaxj3bv	114	28	,	,	,
cord-001293-dfaxj3bv	114	29	CD36	CD36	NNP
cord-001293-dfaxj3bv	114	30	,	,	,
cord-001293-dfaxj3bv	114	31	or	or	CC
cord-001293-dfaxj3bv	114	32	TLR2	TLR2	NNP
cord-001293-dfaxj3bv	114	33	deficiency	deficiency	NN
cord-001293-dfaxj3bv	114	34	protect	protect	VBP
cord-001293-dfaxj3bv	114	35	mice	mouse	NNS
cord-001293-dfaxj3bv	114	36	against	against	IN
cord-001293-dfaxj3bv	114	37	peritoneal	peritoneal	JJ
cord-001293-dfaxj3bv	114	38	S.	S.	NNP
cord-001293-dfaxj3bv	114	39	aureus	aureus	NN
cord-001293-dfaxj3bv	114	40	infection	infection	NN
cord-001293-dfaxj3bv	114	41	while	while	IN
cord-001293-dfaxj3bv	114	42	these	these	DT
cord-001293-dfaxj3bv	114	43	deficiencies	deficiency	NNS
cord-001293-dfaxj3bv	114	44	aggravated	aggravate	VBD
cord-001293-dfaxj3bv	114	45	pneumonia	pneumonia	NN
cord-001293-dfaxj3bv	114	46	[	[	-LRB-
cord-001293-dfaxj3bv	114	47	62	62	CD
cord-001293-dfaxj3bv	114	48	]	]	-RRB-
cord-001293-dfaxj3bv	114	49	.	.	.
cord-001293-dfaxj3bv	115	1	Interestingly	interestingly	RB
cord-001293-dfaxj3bv	115	2	,	,	,
cord-001293-dfaxj3bv	115	3	when	when	WRB
cord-001293-dfaxj3bv	115	4	Streptococcus	streptococcus	NN
cord-001293-dfaxj3bv	115	5	pneumoniae	pneumoniae	NN
cord-001293-dfaxj3bv	115	6	was	be	VBD
cord-001293-dfaxj3bv	115	7	the	the	DT
cord-001293-dfaxj3bv	115	8	pathogen	pathogen	NN
cord-001293-dfaxj3bv	115	9	used	use	VBN
cord-001293-dfaxj3bv	115	10	to	to	TO
cord-001293-dfaxj3bv	115	11	colonize	colonize	VB
cord-001293-dfaxj3bv	115	12	the	the	DT
cord-001293-dfaxj3bv	115	13	murine	murine	JJ
cord-001293-dfaxj3bv	115	14	nasopharynx	nasopharynx	NN
cord-001293-dfaxj3bv	115	15	,	,	,
cord-001293-dfaxj3bv	115	16	MARCO	MARCO	NNP
cord-001293-dfaxj3bv	115	17	KO	KO	NNP
cord-001293-dfaxj3bv	115	18	mice	mouse	NNS
cord-001293-dfaxj3bv	115	19	(	(	-LRB-
cord-001293-dfaxj3bv	115	20	but	but	CC
cord-001293-dfaxj3bv	115	21	not	not	RB
cord-001293-dfaxj3bv	115	22	SR	SR	NNP
cord-001293-dfaxj3bv	115	23	-	-	HYPH
cord-001293-dfaxj3bv	115	24	A	A	NNP
cord-001293-dfaxj3bv	115	25	KO	KO	NNP
cord-001293-dfaxj3bv	115	26	mice	mouse	NNS
cord-001293-dfaxj3bv	115	27	)	)	-RRB-
cord-001293-dfaxj3bv	115	28	had	have	VBD
cord-001293-dfaxj3bv	115	29	significantly	significantly	RB
cord-001293-dfaxj3bv	115	30	impaired	impair	VBN
cord-001293-dfaxj3bv	115	31	clearance	clearance	NN
cord-001293-dfaxj3bv	115	32	of	of	IN
cord-001293-dfaxj3bv	115	33	pneumococcal	pneumococcal	JJ
cord-001293-dfaxj3bv	115	34	colonization	colonization	NN
cord-001293-dfaxj3bv	115	35	[	[	-LRB-
cord-001293-dfaxj3bv	115	36	63	63	CD
cord-001293-dfaxj3bv	115	37	]	]	-RRB-
cord-001293-dfaxj3bv	115	38	.	.	.
cord-001293-dfaxj3bv	116	1	Furthermore	furthermore	RB
cord-001293-dfaxj3bv	116	2	,	,	,
cord-001293-dfaxj3bv	116	3	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	116	4	foci	foci	NN
cord-001293-dfaxj3bv	116	5	cells	cell	NNS
cord-001293-dfaxj3bv	116	6	may	may	MD
cord-001293-dfaxj3bv	116	7	not	not	RB
cord-001293-dfaxj3bv	116	8	behave	behave	VB
cord-001293-dfaxj3bv	116	9	similarly	similarly	RB
cord-001293-dfaxj3bv	116	10	to	to	TO
cord-001293-dfaxj3bv	116	11	cells	cell	NNS
cord-001293-dfaxj3bv	116	12	from	from	IN
cord-001293-dfaxj3bv	116	13	other	other	JJ
cord-001293-dfaxj3bv	116	14	healthy	healthy	JJ
cord-001293-dfaxj3bv	116	15	compartments	compartment	NNS
cord-001293-dfaxj3bv	116	16	.	.	.
cord-001293-dfaxj3bv	117	1	For	for	IN
cord-001293-dfaxj3bv	117	2	example	example	NN
cord-001293-dfaxj3bv	117	3	,	,	,
cord-001293-dfaxj3bv	117	4	it	-PRON-	PRP
cord-001293-dfaxj3bv	117	5	was	be	VBD
cord-001293-dfaxj3bv	117	6	shown	show	VBN
cord-001293-dfaxj3bv	117	7	that	that	IN
cord-001293-dfaxj3bv	117	8	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	117	9	derived	derive	VBN
cord-001293-dfaxj3bv	117	10	from	from	IN
cord-001293-dfaxj3bv	117	11	sputum	sputum	NN
cord-001293-dfaxj3bv	117	12	of	of	IN
cord-001293-dfaxj3bv	117	13	patients	patient	NNS
cord-001293-dfaxj3bv	117	14	with	with	IN
cord-001293-dfaxj3bv	117	15	chronic	chronic	JJ
cord-001293-dfaxj3bv	117	16	bronchitis	bronchitis	NN
cord-001293-dfaxj3bv	117	17	or	or	CC
cord-001293-dfaxj3bv	117	18	cystic	cystic	JJ
cord-001293-dfaxj3bv	117	19	fibrosis	fibrosis	NN
cord-001293-dfaxj3bv	117	20	are	be	VBP
cord-001293-dfaxj3bv	117	21	insensitive	insensitive	JJ
cord-001293-dfaxj3bv	117	22	to	to	IN
cord-001293-dfaxj3bv	117	23	inhibitory	inhibitory	JJ
cord-001293-dfaxj3bv	117	24	effects	effect	NNS
cord-001293-dfaxj3bv	117	25	of	of	IN
cord-001293-dfaxj3bv	117	26	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	117	27	in	in	IN
cord-001293-dfaxj3bv	117	28	contrast	contrast	NN
cord-001293-dfaxj3bv	117	29	to	to	IN
cord-001293-dfaxj3bv	117	30	circulating	circulate	VBG
cord-001293-dfaxj3bv	117	31	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	117	32	[	[	-LRB-
cord-001293-dfaxj3bv	117	33	64	64	CD
cord-001293-dfaxj3bv	117	34	]	]	-RRB-
cord-001293-dfaxj3bv	117	35	.	.	.
cord-001293-dfaxj3bv	118	1	The	the	DT
cord-001293-dfaxj3bv	118	2	concomitant	concomitant	JJ
cord-001293-dfaxj3bv	118	3	presence	presence	NN
cord-001293-dfaxj3bv	118	4	of	of	IN
cord-001293-dfaxj3bv	118	5	inflammation	inflammation	NN
cord-001293-dfaxj3bv	118	6	within	within	IN
cord-001293-dfaxj3bv	118	7	tissues	tissue	NNS
cord-001293-dfaxj3bv	118	8	and	and	CC
cord-001293-dfaxj3bv	118	9	altered	alter	VBN
cord-001293-dfaxj3bv	118	10	immune	immune	JJ
cord-001293-dfaxj3bv	118	11	status	status	NN
cord-001293-dfaxj3bv	118	12	within	within	IN
cord-001293-dfaxj3bv	118	13	the	the	DT
cord-001293-dfaxj3bv	118	14	hematopoietic	hematopoietic	JJ
cord-001293-dfaxj3bv	118	15	compartment	compartment	NN
cord-001293-dfaxj3bv	118	16	is	be	VBZ
cord-001293-dfaxj3bv	118	17	short	short	RB
cord-001293-dfaxj3bv	118	18	-	-	HYPH
cord-001293-dfaxj3bv	118	19	lived	live	VBN
cord-001293-dfaxj3bv	118	20	in	in	IN
cord-001293-dfaxj3bv	118	21	murine	murine	JJ
cord-001293-dfaxj3bv	118	22	models	model	NNS
cord-001293-dfaxj3bv	118	23	rendering	render	VBG
cord-001293-dfaxj3bv	118	24	them	-PRON-	PRP
cord-001293-dfaxj3bv	118	25	inappropriate	inappropriate	JJ
cord-001293-dfaxj3bv	118	26	to	to	TO
cord-001293-dfaxj3bv	118	27	study	study	VB
cord-001293-dfaxj3bv	118	28	patients	patient	NNS
cord-001293-dfaxj3bv	118	29	with	with	IN
cord-001293-dfaxj3bv	118	30	concomitant	concomitant	JJ
cord-001293-dfaxj3bv	118	31	sepsis	sepsis	NN
cord-001293-dfaxj3bv	118	32	and	and	CC
cord-001293-dfaxj3bv	118	33	CARS	car	NNS
cord-001293-dfaxj3bv	118	34	[	[	-LRB-
cord-001293-dfaxj3bv	118	35	65	65	CD
cord-001293-dfaxj3bv	118	36	]	]	-RRB-
cord-001293-dfaxj3bv	118	37	.	.	.
cord-001293-dfaxj3bv	119	1	In	in	IN
cord-001293-dfaxj3bv	119	2	addition	addition	NN
cord-001293-dfaxj3bv	119	3	,	,	,
cord-001293-dfaxj3bv	119	4	mice	mouse	NNS
cord-001293-dfaxj3bv	119	5	are	be	VBP
cord-001293-dfaxj3bv	119	6	highly	highly	RB
cord-001293-dfaxj3bv	119	7	resistant	resistant	JJ
cord-001293-dfaxj3bv	119	8	to	to	IN
cord-001293-dfaxj3bv	119	9	bacteria	bacteria	NNS
cord-001293-dfaxj3bv	119	10	like	like	IN
cord-001293-dfaxj3bv	119	11	S.	S.	NNP
cord-001293-dfaxj3bv	119	12	aureus	aureus	NN
cord-001293-dfaxj3bv	119	13	and	and	CC
cord-001293-dfaxj3bv	119	14	their	-PRON-	PRP$
cord-001293-dfaxj3bv	119	15	serum	serum	NN
cord-001293-dfaxj3bv	119	16	contains	contain	VBZ
cord-001293-dfaxj3bv	119	17	factors	factor	NNS
cord-001293-dfaxj3bv	119	18	that	that	WDT
cord-001293-dfaxj3bv	119	19	limit	limit	VBP
cord-001293-dfaxj3bv	119	20	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	119	21	response	response	NN
cord-001293-dfaxj3bv	119	22	intensity	intensity	NN
cord-001293-dfaxj3bv	119	23	as	as	IN
cord-001293-dfaxj3bv	119	24	compared	compare	VBN
cord-001293-dfaxj3bv	119	25	with	with	IN
cord-001293-dfaxj3bv	119	26	human	human	JJ
cord-001293-dfaxj3bv	119	27	serum	serum	NN
cord-001293-dfaxj3bv	119	28	[	[	-LRB-
cord-001293-dfaxj3bv	119	29	66	66	CD
cord-001293-dfaxj3bv	119	30	]	]	-RRB-
cord-001293-dfaxj3bv	119	31	.	.	.
cord-001293-dfaxj3bv	120	1	A	a	DT
cord-001293-dfaxj3bv	120	2	most	most	RBS
cord-001293-dfaxj3bv	120	3	provocative	provocative	JJ
cord-001293-dfaxj3bv	120	4	report	report	NN
cord-001293-dfaxj3bv	120	5	comparing	compare	VBG
cord-001293-dfaxj3bv	120	6	transcriptomic	transcriptomic	JJ
cord-001293-dfaxj3bv	120	7	patterns	pattern	NNS
cord-001293-dfaxj3bv	120	8	of	of	IN
cord-001293-dfaxj3bv	120	9	circulating	circulate	VBG
cord-001293-dfaxj3bv	120	10	cells	cell	NNS
cord-001293-dfaxj3bv	120	11	from	from	IN
cord-001293-dfaxj3bv	120	12	trauma	trauma	NN
cord-001293-dfaxj3bv	120	13	patients	patient	NNS
cord-001293-dfaxj3bv	120	14	,	,	,
cord-001293-dfaxj3bv	120	15	human	human	JJ
cord-001293-dfaxj3bv	120	16	endotoxemia	endotoxemia	NN
cord-001293-dfaxj3bv	120	17	-	-	HYPH
cord-001293-dfaxj3bv	120	18	model	model	NN
cord-001293-dfaxj3bv	120	19	participants	participant	NNS
cord-001293-dfaxj3bv	120	20	,	,	,
cord-001293-dfaxj3bv	120	21	and	and	CC
cord-001293-dfaxj3bv	120	22	murine	murine	JJ
cord-001293-dfaxj3bv	120	23	-	-	HYPH
cord-001293-dfaxj3bv	120	24	model	model	NN
cord-001293-dfaxj3bv	120	25	equivalents	equivalent	NNS
cord-001293-dfaxj3bv	120	26	revealed	reveal	VBD
cord-001293-dfaxj3bv	120	27	total	total	JJ
cord-001293-dfaxj3bv	120	28	absence	absence	NN
cord-001293-dfaxj3bv	120	29	of	of	IN
cord-001293-dfaxj3bv	120	30	correlation	correlation	NN
cord-001293-dfaxj3bv	120	31	[	[	-LRB-
cord-001293-dfaxj3bv	120	32	67	67	CD
cord-001293-dfaxj3bv	120	33	]	]	-RRB-
cord-001293-dfaxj3bv	120	34	.	.	.
cord-001293-dfaxj3bv	121	1	When	when	WRB
cord-001293-dfaxj3bv	121	2	most	most	JJS
cord-001293-dfaxj3bv	121	3	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	121	4	approaches	approach	NNS
cord-001293-dfaxj3bv	121	5	have	have	VBP
cord-001293-dfaxj3bv	121	6	been	be	VBN
cord-001293-dfaxj3bv	121	7	validated	validate	VBN
cord-001293-dfaxj3bv	121	8	in	in	IN
cord-001293-dfaxj3bv	121	9	preclinical	preclinical	JJ
cord-001293-dfaxj3bv	121	10	studies	study	NNS
cord-001293-dfaxj3bv	121	11	performed	perform	VBN
cord-001293-dfaxj3bv	121	12	with	with	IN
cord-001293-dfaxj3bv	121	13	murine	murine	JJ
cord-001293-dfaxj3bv	121	14	models	model	NNS
cord-001293-dfaxj3bv	121	15	,	,	,
cord-001293-dfaxj3bv	121	16	one	one	PRP
cord-001293-dfaxj3bv	121	17	understands	understand	VBZ
cord-001293-dfaxj3bv	121	18	why	why	WRB
cord-001293-dfaxj3bv	121	19	those	those	DT
cord-001293-dfaxj3bv	121	20	were	be	VBD
cord-001293-dfaxj3bv	121	21	not	not	RB
cord-001293-dfaxj3bv	121	22	the	the	DT
cord-001293-dfaxj3bv	121	23	most	most	RBS
cord-001293-dfaxj3bv	121	24	appropriate	appropriate	JJ
cord-001293-dfaxj3bv	121	25	ones	one	NNS
cord-001293-dfaxj3bv	121	26	.	.	.
cord-001293-dfaxj3bv	122	1	The	the	DT
cord-001293-dfaxj3bv	122	2	scientific	scientific	JJ
cord-001293-dfaxj3bv	122	3	community	community	NN
cord-001293-dfaxj3bv	122	4	needs	need	VBZ
cord-001293-dfaxj3bv	122	5	to	to	TO
cord-001293-dfaxj3bv	122	6	reconsider	reconsider	VB
cord-001293-dfaxj3bv	122	7	models	model	NNS
cord-001293-dfaxj3bv	122	8	used	use	VBN
cord-001293-dfaxj3bv	122	9	to	to	TO
cord-001293-dfaxj3bv	122	10	validate	validate	VB
cord-001293-dfaxj3bv	122	11	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	122	12	approaches	approach	NNS
cord-001293-dfaxj3bv	122	13	.	.	.
cord-001293-dfaxj3bv	123	1	If	if	IN
cord-001293-dfaxj3bv	123	2	murine	murine	JJ
cord-001293-dfaxj3bv	123	3	responses	response	NNS
cord-001293-dfaxj3bv	123	4	do	do	VBP
cord-001293-dfaxj3bv	123	5	not	not	RB
cord-001293-dfaxj3bv	123	6	resemble	resemble	VB
cord-001293-dfaxj3bv	123	7	human	human	JJ
cord-001293-dfaxj3bv	123	8	processes	process	NNS
cord-001293-dfaxj3bv	123	9	,	,	,
cord-001293-dfaxj3bv	123	10	maybe	maybe	RB
cord-001293-dfaxj3bv	123	11	other	other	JJ
cord-001293-dfaxj3bv	123	12	species	specie	NNS
cord-001293-dfaxj3bv	123	13	,	,	,
cord-001293-dfaxj3bv	123	14	like	like	IN
cord-001293-dfaxj3bv	123	15	the	the	DT
cord-001293-dfaxj3bv	123	16	pig	pig	NN
cord-001293-dfaxj3bv	123	17	,	,	,
cord-001293-dfaxj3bv	123	18	should	should	MD
cord-001293-dfaxj3bv	123	19	be	be	VB
cord-001293-dfaxj3bv	123	20	preferred	prefer	VBN
cord-001293-dfaxj3bv	123	21	.	.	.
cord-001293-dfaxj3bv	124	1	Porcine	porcine	JJ
cord-001293-dfaxj3bv	124	2	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	124	3	and	and	CC
cord-001293-dfaxj3bv	124	4	LPS	LPS	NNP
cord-001293-dfaxj3bv	124	5	-	-	HYPH
cord-001293-dfaxj3bv	124	6	activated	activate	VBN
cord-001293-dfaxj3bv	124	7	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	124	8	are	be	VBP
cord-001293-dfaxj3bv	124	9	closer	close	JJR
cord-001293-dfaxj3bv	124	10	to	to	IN
cord-001293-dfaxj3bv	124	11	their	-PRON-	PRP$
cord-001293-dfaxj3bv	124	12	human	human	JJ
cord-001293-dfaxj3bv	124	13	counterparts	counterpart	NNS
cord-001293-dfaxj3bv	124	14	than	than	IN
cord-001293-dfaxj3bv	124	15	murine	murine	JJ
cord-001293-dfaxj3bv	124	16	cells	cell	NNS
cord-001293-dfaxj3bv	124	17	[	[	-LRB-
cord-001293-dfaxj3bv	124	18	68	68	CD
cord-001293-dfaxj3bv	124	19	]	]	-RRB-
cord-001293-dfaxj3bv	124	20	.	.	.
cord-001293-dfaxj3bv	125	1	Of	of	RB
cord-001293-dfaxj3bv	125	2	course	course	RB
cord-001293-dfaxj3bv	125	3	,	,	,
cord-001293-dfaxj3bv	125	4	murine	murine	JJ
cord-001293-dfaxj3bv	125	5	models	model	NNS
cord-001293-dfaxj3bv	125	6	remain	remain	VBP
cord-001293-dfaxj3bv	125	7	valuable	valuable	JJ
cord-001293-dfaxj3bv	125	8	to	to	TO
cord-001293-dfaxj3bv	125	9	further	further	RB
cord-001293-dfaxj3bv	125	10	decipher	decipher	VB
cord-001293-dfaxj3bv	125	11	the	the	DT
cord-001293-dfaxj3bv	125	12	mechanisms	mechanism	NNS
cord-001293-dfaxj3bv	125	13	of	of	IN
cord-001293-dfaxj3bv	125	14	sepsis	sepsis	NN
cord-001293-dfaxj3bv	125	15	.	.	.
cord-001293-dfaxj3bv	126	1	The	the	DT
cord-001293-dfaxj3bv	126	2	best	good	JJS
cord-001293-dfaxj3bv	126	3	example	example	NN
cord-001293-dfaxj3bv	126	4	is	be	VBZ
cord-001293-dfaxj3bv	126	5	the	the	DT
cord-001293-dfaxj3bv	126	6	two	two	CD
cord-001293-dfaxj3bv	126	7	-	-	HYPH
cord-001293-dfaxj3bv	126	8	hit	hit	NN
cord-001293-dfaxj3bv	126	9	model	model	NN
cord-001293-dfaxj3bv	126	10	,	,	,
cord-001293-dfaxj3bv	126	11	which	which	WDT
cord-001293-dfaxj3bv	126	12	demonstrated	demonstrate	VBD
cord-001293-dfaxj3bv	126	13	that	that	IN
cord-001293-dfaxj3bv	126	14	the	the	DT
cord-001293-dfaxj3bv	126	15	nature	nature	NN
cord-001293-dfaxj3bv	126	16	of	of	IN
cord-001293-dfaxj3bv	126	17	the	the	DT
cord-001293-dfaxj3bv	126	18	first	first	JJ
cord-001293-dfaxj3bv	126	19	hit	hit	NN
cord-001293-dfaxj3bv	126	20	and	and	CC
cord-001293-dfaxj3bv	126	21	its	-PRON-	PRP$
cord-001293-dfaxj3bv	126	22	severity	severity	NN
cord-001293-dfaxj3bv	126	23	,	,	,
cord-001293-dfaxj3bv	126	24	the	the	DT
cord-001293-dfaxj3bv	126	25	nature	nature	NN
cord-001293-dfaxj3bv	126	26	of	of	IN
cord-001293-dfaxj3bv	126	27	the	the	DT
cord-001293-dfaxj3bv	126	28	infection	infection	NN
cord-001293-dfaxj3bv	126	29	,	,	,
cord-001293-dfaxj3bv	126	30	and	and	CC
cord-001293-dfaxj3bv	126	31	the	the	DT
cord-001293-dfaxj3bv	126	32	route	route	NN
cord-001293-dfaxj3bv	126	33	of	of	IN
cord-001293-dfaxj3bv	126	34	infection	infection	NN
cord-001293-dfaxj3bv	126	35	may	may	MD
cord-001293-dfaxj3bv	126	36	influence	influence	VB
cord-001293-dfaxj3bv	126	37	the	the	DT
cord-001293-dfaxj3bv	126	38	outcome	outcome	NN
cord-001293-dfaxj3bv	126	39	in	in	IN
cord-001293-dfaxj3bv	126	40	a	a	DT
cord-001293-dfaxj3bv	126	41	completely	completely	RB
cord-001293-dfaxj3bv	126	42	opposite	opposite	JJ
cord-001293-dfaxj3bv	126	43	direction	direction	NN
cord-001293-dfaxj3bv	126	44	[	[	-LRB-
cord-001293-dfaxj3bv	126	45	69	69	CD
cord-001293-dfaxj3bv	126	46	]	]	-RRB-
cord-001293-dfaxj3bv	126	47	.	.	.
cord-001293-dfaxj3bv	127	1	Are	be	VBP
cord-001293-dfaxj3bv	127	2	patients	patient	NNS
cord-001293-dfaxj3bv	127	3	with	with	IN
cord-001293-dfaxj3bv	127	4	sepsis	sepsis	NN
cord-001293-dfaxj3bv	127	5	dying	die	VBG
cord-001293-dfaxj3bv	127	6	of	of	IN
cord-001293-dfaxj3bv	127	7	immune	immune	JJ
cord-001293-dfaxj3bv	127	8	failure	failure	NN
cord-001293-dfaxj3bv	127	9	-dissecting	-dissecting	:
cord-001293-dfaxj3bv	127	10	the	the	DT
cord-001293-dfaxj3bv	127	11	arguments	argument	NNS
cord-001293-dfaxj3bv	127	12	used	use	VBD
cord-001293-dfaxj3bv	127	13	to	to	TO
cord-001293-dfaxj3bv	127	14	describe	describe	VB
cord-001293-dfaxj3bv	127	15	compensatory	compensatory	JJ
cord-001293-dfaxj3bv	127	16	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	127	17	occurring	occur	VBG
cord-001293-dfaxj3bv	127	18	after	after	IN
cord-001293-dfaxj3bv	127	19	sepsis	sepsis	NN
cord-001293-dfaxj3bv	127	20	?	?	.
cord-001293-dfaxj3bv	128	1	The	the	DT
cord-001293-dfaxj3bv	128	2	clinical	clinical	JJ
cord-001293-dfaxj3bv	128	3	observations	observation	NNS
cord-001293-dfaxj3bv	128	4	used	use	VBN
cord-001293-dfaxj3bv	128	5	to	to	TO
cord-001293-dfaxj3bv	128	6	argue	argue	VB
cord-001293-dfaxj3bv	128	7	that	that	IN
cord-001293-dfaxj3bv	128	8	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	128	9	occurs	occur	VBZ
cord-001293-dfaxj3bv	128	10	in	in	IN
cord-001293-dfaxj3bv	128	11	sepsis	sepsis	NN
cord-001293-dfaxj3bv	128	12	patients	patient	NNS
cord-001293-dfaxj3bv	128	13	surviving	survive	VBG
cord-001293-dfaxj3bv	128	14	the	the	DT
cord-001293-dfaxj3bv	128	15	initial	initial	JJ
cord-001293-dfaxj3bv	128	16	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	128	17	cascade	cascade	NN
cord-001293-dfaxj3bv	128	18	[	[	-LRB-
cord-001293-dfaxj3bv	128	19	1	1	CD
cord-001293-dfaxj3bv	128	20	]	]	-RRB-
cord-001293-dfaxj3bv	128	21	are	be	VBP
cord-001293-dfaxj3bv	128	22	in	in	IN
cord-001293-dfaxj3bv	128	23	essence	essence	NN
cord-001293-dfaxj3bv	128	24	that	that	WDT
cord-001293-dfaxj3bv	128	25	patients	patient	NNS
cord-001293-dfaxj3bv	128	26	develop	develop	VBP
cord-001293-dfaxj3bv	128	27	nosocomial	nosocomial	JJ
cord-001293-dfaxj3bv	128	28	infections	infection	NNS
cord-001293-dfaxj3bv	128	29	due	due	JJ
cord-001293-dfaxj3bv	128	30	to	to	IN
cord-001293-dfaxj3bv	128	31	opportunistic	opportunistic	JJ
cord-001293-dfaxj3bv	128	32	pathogens	pathogen	NNS
cord-001293-dfaxj3bv	128	33	,	,	,
cord-001293-dfaxj3bv	128	34	including	include	VBG
cord-001293-dfaxj3bv	128	35	reactivated	reactivate	VBN
cord-001293-dfaxj3bv	128	36	chronic	chronic	JJ
cord-001293-dfaxj3bv	128	37	viral	viral	JJ
cord-001293-dfaxj3bv	128	38	infections	infection	NNS
cord-001293-dfaxj3bv	128	39	,	,	,
cord-001293-dfaxj3bv	128	40	and	and	CC
cord-001293-dfaxj3bv	128	41	that	that	IN
cord-001293-dfaxj3bv	128	42	patients	patient	NNS
cord-001293-dfaxj3bv	128	43	who	who	WP
cord-001293-dfaxj3bv	128	44	die	die	VBP
cord-001293-dfaxj3bv	128	45	after	after	IN
cord-001293-dfaxj3bv	128	46	sepsis	sepsis	NN
cord-001293-dfaxj3bv	128	47	have	have	VBP
cord-001293-dfaxj3bv	128	48	unresolved	unresolved	JJ
cord-001293-dfaxj3bv	128	49	foci	foci	NN
cord-001293-dfaxj3bv	128	50	of	of	IN
cord-001293-dfaxj3bv	128	51	infection	infection	NN
cord-001293-dfaxj3bv	128	52	.	.	.
cord-001293-dfaxj3bv	129	1	These	these	DT
cord-001293-dfaxj3bv	129	2	underpinning	underpinning	NN
cord-001293-dfaxj3bv	129	3	observations	observation	NNS
cord-001293-dfaxj3bv	129	4	require	require	VBP
cord-001293-dfaxj3bv	129	5	further	further	JJ
cord-001293-dfaxj3bv	129	6	consideration	consideration	NN
cord-001293-dfaxj3bv	129	7	.	.	.
cord-001293-dfaxj3bv	130	1	Representing	represent	VBG
cord-001293-dfaxj3bv	130	2	bacteria	bacteria	NNS
cord-001293-dfaxj3bv	130	3	such	such	JJ
cord-001293-dfaxj3bv	130	4	as	as	IN
cord-001293-dfaxj3bv	130	5	Enterococcus	Enterococcus	NNP
cord-001293-dfaxj3bv	130	6	faecium	faecium	NN
cord-001293-dfaxj3bv	130	7	,	,	,
cord-001293-dfaxj3bv	130	8	Stentrophomonas	Stentrophomonas	NNP
cord-001293-dfaxj3bv	130	9	maltophilia	maltophilia	NNP
cord-001293-dfaxj3bv	130	10	,	,	,
cord-001293-dfaxj3bv	130	11	and	and	CC
cord-001293-dfaxj3bv	130	12	Pseudomonas	Pseudomonas	NNP
cord-001293-dfaxj3bv	130	13	aeruginosa	aeruginosa	VBZ
cord-001293-dfaxj3bv	130	14	along	along	RP
cord-001293-dfaxj3bv	130	15	with	with	IN
cord-001293-dfaxj3bv	130	16	Candida	Candida	NNP
cord-001293-dfaxj3bv	130	17	as	as	IN
cord-001293-dfaxj3bv	130	18	'	'	``
cord-001293-dfaxj3bv	130	19	opportunistic	opportunistic	JJ
cord-001293-dfaxj3bv	130	20	pathogens	pathogen	NNS
cord-001293-dfaxj3bv	130	21	'	'	POS
cord-001293-dfaxj3bv	130	22	overstates	overstate	VBZ
cord-001293-dfaxj3bv	130	23	the	the	DT
cord-001293-dfaxj3bv	130	24	role	role	NN
cord-001293-dfaxj3bv	130	25	of	of	IN
cord-001293-dfaxj3bv	130	26	sepsis	sepsis	NN
cord-001293-dfaxj3bv	130	27	-	-	HYPH
cord-001293-dfaxj3bv	130	28	induced	induce	VBN
cord-001293-dfaxj3bv	130	29	immune	immune	JJ
cord-001293-dfaxj3bv	130	30	dysregulation	dysregulation	NN
cord-001293-dfaxj3bv	130	31	as	as	IN
cord-001293-dfaxj3bv	130	32	the	the	DT
cord-001293-dfaxj3bv	130	33	primary	primary	JJ
cord-001293-dfaxj3bv	130	34	cause	cause	NN
cord-001293-dfaxj3bv	130	35	of	of	IN
cord-001293-dfaxj3bv	130	36	nosocomial	nosocomial	JJ
cord-001293-dfaxj3bv	130	37	infection	infection	NN
cord-001293-dfaxj3bv	130	38	in	in	IN
cord-001293-dfaxj3bv	130	39	these	these	DT
cord-001293-dfaxj3bv	130	40	patients	patient	NNS
cord-001293-dfaxj3bv	130	41	.	.	.
cord-001293-dfaxj3bv	131	1	These	these	DT
cord-001293-dfaxj3bv	131	2	multiply	multiply	VB
cord-001293-dfaxj3bv	131	3	-	-	HYPH
cord-001293-dfaxj3bv	131	4	instrumented	instrumented	JJ
cord-001293-dfaxj3bv	131	5	,	,	,
cord-001293-dfaxj3bv	131	6	high	high	JJ
cord-001293-dfaxj3bv	131	7	-	-	HYPH
cord-001293-dfaxj3bv	131	8	intensity	intensity	NN
cord-001293-dfaxj3bv	131	9	care	care	NN
cord-001293-dfaxj3bv	131	10	,	,	,
cord-001293-dfaxj3bv	131	11	bed	bed	NN
cord-001293-dfaxj3bv	131	12	-	-	HYPH
cord-001293-dfaxj3bv	131	13	bound	bind	VBN
cord-001293-dfaxj3bv	131	14	,	,	,
cord-001293-dfaxj3bv	131	15	vulnerable	vulnerable	JJ
cord-001293-dfaxj3bv	131	16	patients	patient	NNS
cord-001293-dfaxj3bv	131	17	often	often	RB
cord-001293-dfaxj3bv	131	18	have	have	VBP
cord-001293-dfaxj3bv	131	19	breaches	breach	NNS
cord-001293-dfaxj3bv	131	20	in	in	IN
cord-001293-dfaxj3bv	131	21	their	-PRON-	PRP$
cord-001293-dfaxj3bv	131	22	integument	integument	NN
cord-001293-dfaxj3bv	131	23	and	and	CC
cord-001293-dfaxj3bv	131	24	mucous	mucous	JJ
cord-001293-dfaxj3bv	131	25	membranes	membrane	NNS
cord-001293-dfaxj3bv	131	26	(	(	-LRB-
cord-001293-dfaxj3bv	131	27	airways	airway	NNS
cord-001293-dfaxj3bv	131	28	,	,	,
cord-001293-dfaxj3bv	131	29	surgical	surgical	JJ
cord-001293-dfaxj3bv	131	30	sites	site	NNS
cord-001293-dfaxj3bv	131	31	,	,	,
cord-001293-dfaxj3bv	131	32	indwelling	indwell	VBG
cord-001293-dfaxj3bv	131	33	catheters	catheter	NNS
cord-001293-dfaxj3bv	131	34	)	)	-RRB-
cord-001293-dfaxj3bv	131	35	and	and	CC
cord-001293-dfaxj3bv	131	36	perturbed	perturb	VBD
cord-001293-dfaxj3bv	131	37	microbiomes	microbiome	NNS
cord-001293-dfaxj3bv	131	38	from	from	IN
cord-001293-dfaxj3bv	131	39	antibiotic	antibiotic	JJ
cord-001293-dfaxj3bv	131	40	treatments	treatment	NNS
cord-001293-dfaxj3bv	131	41	.	.	.
cord-001293-dfaxj3bv	132	1	Overgrowth	overgrowth	NN
cord-001293-dfaxj3bv	132	2	of	of	IN
cord-001293-dfaxj3bv	132	3	antibioticresistant	antibioticresistant	JJ
cord-001293-dfaxj3bv	132	4	microorganisms	microorganism	NNS
cord-001293-dfaxj3bv	132	5	and	and	CC
cord-001293-dfaxj3bv	132	6	barrier	barrier	NN
cord-001293-dfaxj3bv	132	7	defects	defect	NNS
cord-001293-dfaxj3bv	132	8	predispose	predispose	VBP
cord-001293-dfaxj3bv	132	9	them	-PRON-	PRP
cord-001293-dfaxj3bv	132	10	to	to	IN
cord-001293-dfaxj3bv	132	11	secondary	secondary	JJ
cord-001293-dfaxj3bv	132	12	infections	infection	NNS
cord-001293-dfaxj3bv	132	13	,	,	,
cord-001293-dfaxj3bv	132	14	even	even	RB
cord-001293-dfaxj3bv	132	15	without	without	IN
cord-001293-dfaxj3bv	132	16	overt	overt	JJ
cord-001293-dfaxj3bv	132	17	defects	defect	NNS
cord-001293-dfaxj3bv	132	18	in	in	IN
cord-001293-dfaxj3bv	132	19	their	-PRON-	PRP$
cord-001293-dfaxj3bv	132	20	immune	immune	JJ
cord-001293-dfaxj3bv	132	21	defenses	defense	NNS
cord-001293-dfaxj3bv	132	22	[	[	-LRB-
cord-001293-dfaxj3bv	132	23	70	70	CD
cord-001293-dfaxj3bv	132	24	]	]	-RRB-
cord-001293-dfaxj3bv	132	25	.	.	.
cord-001293-dfaxj3bv	133	1	These	these	DT
cord-001293-dfaxj3bv	133	2	are	be	VBP
cord-001293-dfaxj3bv	133	3	all	all	DT
cord-001293-dfaxj3bv	133	4	organisms	organism	NNS
cord-001293-dfaxj3bv	133	5	of	of	IN
cord-001293-dfaxj3bv	133	6	normal	normal	JJ
cord-001293-dfaxj3bv	133	7	virulence	virulence	NN
cord-001293-dfaxj3bv	133	8	that	that	WDT
cord-001293-dfaxj3bv	133	9	cause	cause	VBP
cord-001293-dfaxj3bv	133	10	nosocomial	nosocomial	JJ
cord-001293-dfaxj3bv	133	11	infections	infection	NNS
cord-001293-dfaxj3bv	133	12	in	in	IN
cord-001293-dfaxj3bv	133	13	sepsis	sepsis	NN
cord-001293-dfaxj3bv	133	14	patients	patient	NNS
cord-001293-dfaxj3bv	133	15	because	because	IN
cord-001293-dfaxj3bv	133	16	of	of	IN
cord-001293-dfaxj3bv	133	17	the	the	DT
cord-001293-dfaxj3bv	133	18	selection	selection	NN
cord-001293-dfaxj3bv	133	19	pressure	pressure	NN
cord-001293-dfaxj3bv	133	20	of	of	IN
cord-001293-dfaxj3bv	133	21	potent	potent	JJ
cord-001293-dfaxj3bv	133	22	antibiotics	antibiotic	NNS
cord-001293-dfaxj3bv	133	23	and	and	CC
cord-001293-dfaxj3bv	133	24	the	the	DT
cord-001293-dfaxj3bv	133	25	presence	presence	NN
cord-001293-dfaxj3bv	133	26	of	of	IN
cord-001293-dfaxj3bv	133	27	biofilm	biofilm	NN
cord-001293-dfaxj3bv	133	28	affected	affect	VBN
cord-001293-dfaxj3bv	133	29	/	/	SYM
cord-001293-dfaxj3bv	133	30	colonized	colonize	VBN
cord-001293-dfaxj3bv	133	31	intravascular	intravascular	JJ
cord-001293-dfaxj3bv	133	32	and	and	CC
cord-001293-dfaxj3bv	133	33	urinary	urinary	JJ
cord-001293-dfaxj3bv	133	34	catheters	catheter	NNS
cord-001293-dfaxj3bv	133	35	.	.	.
cord-001293-dfaxj3bv	134	1	Additionally	additionally	RB
cord-001293-dfaxj3bv	134	2	,	,	,
cord-001293-dfaxj3bv	134	3	reactivation	reactivation	NN
cord-001293-dfaxj3bv	134	4	of	of	IN
cord-001293-dfaxj3bv	134	5	herpes	herpes	NNP
cord-001293-dfaxj3bv	134	6	simplex	simplex	NNP
cord-001293-dfaxj3bv	134	7	virus	virus	NN
cord-001293-dfaxj3bv	134	8	(	(	-LRB-
cord-001293-dfaxj3bv	134	9	HSV	HSV	NNP
cord-001293-dfaxj3bv	134	10	)	)	-RRB-
cord-001293-dfaxj3bv	134	11	and	and	CC
cord-001293-dfaxj3bv	134	12	cytomegalovirus	cytomegalovirus	NNP
cord-001293-dfaxj3bv	134	13	(	(	-LRB-
cord-001293-dfaxj3bv	134	14	CMV	CMV	NNP
cord-001293-dfaxj3bv	134	15	)	)	-RRB-
cord-001293-dfaxj3bv	134	16	may	may	MD
cord-001293-dfaxj3bv	134	17	have	have	VB
cord-001293-dfaxj3bv	134	18	some	some	DT
cord-001293-dfaxj3bv	134	19	clinical	clinical	JJ
cord-001293-dfaxj3bv	134	20	relevance	relevance	NN
cord-001293-dfaxj3bv	134	21	in	in	IN
cord-001293-dfaxj3bv	134	22	critically	critically	RB
cord-001293-dfaxj3bv	134	23	ill	ill	JJ
cord-001293-dfaxj3bv	134	24	patients	patient	NNS
cord-001293-dfaxj3bv	134	25	.	.	.
cord-001293-dfaxj3bv	135	1	CMV	CMV	NNP
cord-001293-dfaxj3bv	135	2	-	-	HYPH
cord-001293-dfaxj3bv	135	3	emia	emia	NNP
cord-001293-dfaxj3bv	135	4	is	be	VBZ
cord-001293-dfaxj3bv	135	5	quite	quite	RB
cord-001293-dfaxj3bv	135	6	common	common	JJ
cord-001293-dfaxj3bv	135	7	in	in	IN
cord-001293-dfaxj3bv	135	8	patients	patient	NNS
cord-001293-dfaxj3bv	135	9	with	with	IN
cord-001293-dfaxj3bv	135	10	sepsis	sepsis	NN
cord-001293-dfaxj3bv	135	11	(	(	-LRB-
cord-001293-dfaxj3bv	135	12	30	30	CD
cord-001293-dfaxj3bv	135	13	%	%	NN
cord-001293-dfaxj3bv	135	14	in	in	IN
cord-001293-dfaxj3bv	135	15	some	some	DT
cord-001293-dfaxj3bv	135	16	studies	study	NNS
cord-001293-dfaxj3bv	135	17	)	)	-RRB-
cord-001293-dfaxj3bv	135	18	and	and	CC
cord-001293-dfaxj3bv	135	19	is	be	VBZ
cord-001293-dfaxj3bv	135	20	at	at	IN
cord-001293-dfaxj3bv	135	21	least	least	JJS
cord-001293-dfaxj3bv	135	22	associated	associate	VBN
cord-001293-dfaxj3bv	135	23	with	with	IN
cord-001293-dfaxj3bv	135	24	worse	bad	JJR
cord-001293-dfaxj3bv	135	25	outcome	outcome	NN
cord-001293-dfaxj3bv	135	26	in	in	IN
cord-001293-dfaxj3bv	135	27	ICU	ICU	NNP
cord-001293-dfaxj3bv	135	28	patients	patient	NNS
cord-001293-dfaxj3bv	135	29	in	in	IN
cord-001293-dfaxj3bv	135	30	recent	recent	JJ
cord-001293-dfaxj3bv	135	31	meta	meta	JJ
cord-001293-dfaxj3bv	135	32	-	-	HYPH
cord-001293-dfaxj3bv	135	33	analyses	analysis	NNS
cord-001293-dfaxj3bv	135	34	.	.	.
cord-001293-dfaxj3bv	136	1	Whether	whether	IN
cord-001293-dfaxj3bv	136	2	CMV	CMV	NNP
cord-001293-dfaxj3bv	136	3	could	could	MD
cord-001293-dfaxj3bv	136	4	cause	cause	VB
cord-001293-dfaxj3bv	136	5	immune	immune	JJ
cord-001293-dfaxj3bv	136	6	compromise	compromise	NN
cord-001293-dfaxj3bv	136	7	itself	-PRON-	PRP
cord-001293-dfaxj3bv	136	8	,	,	,
cord-001293-dfaxj3bv	136	9	be	be	VB
cord-001293-dfaxj3bv	136	10	a	a	DT
cord-001293-dfaxj3bv	136	11	reflection	reflection	NN
cord-001293-dfaxj3bv	136	12	of	of	IN
cord-001293-dfaxj3bv	136	13	immune	immune	JJ
cord-001293-dfaxj3bv	136	14	compromise	compromise	NN
cord-001293-dfaxj3bv	136	15	,	,	,
cord-001293-dfaxj3bv	136	16	or	or	CC
cord-001293-dfaxj3bv	136	17	simply	simply	RB
cord-001293-dfaxj3bv	136	18	be	be	VB
cord-001293-dfaxj3bv	136	19	an	an	DT
cord-001293-dfaxj3bv	136	20	indicator	indicator	NN
cord-001293-dfaxj3bv	136	21	of	of	IN
cord-001293-dfaxj3bv	136	22	poor	poor	JJ
cord-001293-dfaxj3bv	136	23	outcome	outcome	NN
cord-001293-dfaxj3bv	136	24	in	in	IN
cord-001293-dfaxj3bv	136	25	patients	patient	NNS
cord-001293-dfaxj3bv	136	26	with	with	IN
cord-001293-dfaxj3bv	136	27	sepsis	sepsis	NN
cord-001293-dfaxj3bv	136	28	remains	remain	VBZ
cord-001293-dfaxj3bv	136	29	unclear	unclear	JJ
cord-001293-dfaxj3bv	136	30	[	[	-LRB-
cord-001293-dfaxj3bv	136	31	71	71	CD
cord-001293-dfaxj3bv	136	32	]	]	-RRB-
cord-001293-dfaxj3bv	136	33	.	.	.
cord-001293-dfaxj3bv	137	1	Reactivation	reactivation	NN
cord-001293-dfaxj3bv	137	2	of	of	IN
cord-001293-dfaxj3bv	137	3	oro	oro	NNP
cord-001293-dfaxj3bv	137	4	-	-	HYPH
cord-001293-dfaxj3bv	137	5	labial	labial	JJ
cord-001293-dfaxj3bv	137	6	HSV	HSV	NNP
cord-001293-dfaxj3bv	137	7	is	be	VBZ
cord-001293-dfaxj3bv	137	8	extremely	extremely	RB
cord-001293-dfaxj3bv	137	9	common	common	JJ
cord-001293-dfaxj3bv	137	10	in	in	IN
cord-001293-dfaxj3bv	137	11	sepsis	sepsis	NN
cord-001293-dfaxj3bv	137	12	,	,	,
cord-001293-dfaxj3bv	137	13	and	and	CC
cord-001293-dfaxj3bv	137	14	HSV	HSV	NNP
cord-001293-dfaxj3bv	137	15	can	can	MD
cord-001293-dfaxj3bv	137	16	frequently	frequently	RB
cord-001293-dfaxj3bv	137	17	be	be	VB
cord-001293-dfaxj3bv	137	18	detected	detect	VBN
cord-001293-dfaxj3bv	137	19	in	in	IN
cord-001293-dfaxj3bv	137	20	respiratory	respiratory	JJ
cord-001293-dfaxj3bv	137	21	secretions	secretion	NNS
cord-001293-dfaxj3bv	137	22	.	.	.
cord-001293-dfaxj3bv	138	1	However	however	RB
cord-001293-dfaxj3bv	138	2	,	,	,
cord-001293-dfaxj3bv	138	3	only	only	RB
cord-001293-dfaxj3bv	138	4	one	one	CD
cord-001293-dfaxj3bv	138	5	study	study	NN
cord-001293-dfaxj3bv	138	6	has	have	VBZ
cord-001293-dfaxj3bv	138	7	reliably	reliably	RB
cord-001293-dfaxj3bv	138	8	investigated	investigate	VBN
cord-001293-dfaxj3bv	138	9	lower	low	JJR
cord-001293-dfaxj3bv	138	10	respiratory	respiratory	JJ
cord-001293-dfaxj3bv	138	11	tract	tract	NN
cord-001293-dfaxj3bv	138	12	infection	infection	NN
cord-001293-dfaxj3bv	138	13	in	in	IN
cord-001293-dfaxj3bv	138	14	critically	critically	RB
cord-001293-dfaxj3bv	138	15	ill	ill	JJ
cord-001293-dfaxj3bv	138	16	,	,	,
cord-001293-dfaxj3bv	138	17	immunocompetent	immunocompetent	JJ
cord-001293-dfaxj3bv	138	18	patients	patient	NNS
cord-001293-dfaxj3bv	138	19	,	,	,
cord-001293-dfaxj3bv	138	20	showing	show	VBG
cord-001293-dfaxj3bv	138	21	that	that	IN
cord-001293-dfaxj3bv	138	22	21	21	CD
cord-001293-dfaxj3bv	138	23	%	%	NN
cord-001293-dfaxj3bv	138	24	of	of	IN
cord-001293-dfaxj3bv	138	25	patients	patient	NNS
cord-001293-dfaxj3bv	138	26	with	with	IN
cord-001293-dfaxj3bv	138	27	ventilator	ventilator	NN
cord-001293-dfaxj3bv	138	28	-	-	HYPH
cord-001293-dfaxj3bv	138	29	associated	associate	VBN
cord-001293-dfaxj3bv	138	30	pneumonia	pneumonia	NN
cord-001293-dfaxj3bv	138	31	(	(	-LRB-
cord-001293-dfaxj3bv	138	32	VAP	VAP	NNP
cord-001293-dfaxj3bv	138	33	)	)	-RRB-
cord-001293-dfaxj3bv	138	34	had	have	VBD
cord-001293-dfaxj3bv	138	35	bronchopneumonitis	bronchopneumonitis	NNP
cord-001293-dfaxj3bv	138	36	due	due	IN
cord-001293-dfaxj3bv	138	37	to	to	IN
cord-001293-dfaxj3bv	138	38	HSV	HSV	NNP
cord-001293-dfaxj3bv	138	39	[	[	-LRB-
cord-001293-dfaxj3bv	138	40	72	72	CD
cord-001293-dfaxj3bv	138	41	]	]	-RRB-
cord-001293-dfaxj3bv	138	42	.	.	.
cord-001293-dfaxj3bv	139	1	In	in	IN
cord-001293-dfaxj3bv	139	2	55	55	CD
cord-001293-dfaxj3bv	139	3	%	%	NN
cord-001293-dfaxj3bv	139	4	of	of	IN
cord-001293-dfaxj3bv	139	5	these	these	DT
cord-001293-dfaxj3bv	139	6	patients	patient	NNS
cord-001293-dfaxj3bv	139	7	,	,	,
cord-001293-dfaxj3bv	139	8	the	the	DT
cord-001293-dfaxj3bv	139	9	VAP	VAP	NNP
cord-001293-dfaxj3bv	139	10	appeared	appear	VBD
cord-001293-dfaxj3bv	139	11	to	to	TO
cord-001293-dfaxj3bv	139	12	be	be	VB
cord-001293-dfaxj3bv	139	13	due	due	JJ
cord-001293-dfaxj3bv	139	14	to	to	IN
cord-001293-dfaxj3bv	139	15	HSV	HSV	NNP
cord-001293-dfaxj3bv	139	16	alone	alone	RB
cord-001293-dfaxj3bv	139	17	.	.	.
cord-001293-dfaxj3bv	140	1	However	however	RB
cord-001293-dfaxj3bv	140	2	,	,	,
cord-001293-dfaxj3bv	140	3	acyclovir	acyclovir	NN
cord-001293-dfaxj3bv	140	4	treatment	treatment	NN
cord-001293-dfaxj3bv	140	5	had	have	VBD
cord-001293-dfaxj3bv	140	6	no	no	DT
cord-001293-dfaxj3bv	140	7	impact	impact	NN
cord-001293-dfaxj3bv	140	8	on	on	IN
cord-001293-dfaxj3bv	140	9	the	the	DT
cord-001293-dfaxj3bv	140	10	outcome	outcome	NN
cord-001293-dfaxj3bv	140	11	in	in	IN
cord-001293-dfaxj3bv	140	12	patients	patient	NNS
cord-001293-dfaxj3bv	140	13	with	with	IN
cord-001293-dfaxj3bv	140	14	HSV	HSV	NNP
cord-001293-dfaxj3bv	140	15	bronchopneumonitis	bronchopneumonitis	NNP
cord-001293-dfaxj3bv	140	16	[	[	-LRB-
cord-001293-dfaxj3bv	140	17	72	72	CD
cord-001293-dfaxj3bv	140	18	]	]	-RRB-
cord-001293-dfaxj3bv	140	19	.	.	.
cord-001293-dfaxj3bv	141	1	Of	of	IN
cord-001293-dfaxj3bv	141	2	greater	great	JJR
cord-001293-dfaxj3bv	141	3	relevance	relevance	NN
cord-001293-dfaxj3bv	141	4	to	to	IN
cord-001293-dfaxj3bv	141	5	predisposition	predisposition	NN
cord-001293-dfaxj3bv	141	6	to	to	IN
cord-001293-dfaxj3bv	141	7	nosocomial	nosocomial	JJ
cord-001293-dfaxj3bv	141	8	infection	infection	NN
cord-001293-dfaxj3bv	141	9	in	in	IN
cord-001293-dfaxj3bv	141	10	sepsis	sepsis	NN
cord-001293-dfaxj3bv	141	11	patients	patient	NNS
cord-001293-dfaxj3bv	141	12	remaining	remain	VBG
cord-001293-dfaxj3bv	141	13	in	in	IN
cord-001293-dfaxj3bv	141	14	ICUs	ICUs	NNP
cord-001293-dfaxj3bv	141	15	for	for	IN
cord-001293-dfaxj3bv	141	16	prolonged	prolonged	JJ
cord-001293-dfaxj3bv	141	17	periods	period	NNS
cord-001293-dfaxj3bv	141	18	are	be	VBP
cord-001293-dfaxj3bv	141	19	physical	physical	JJ
cord-001293-dfaxj3bv	141	20	breaches	breach	NNS
cord-001293-dfaxj3bv	141	21	in	in	IN
cord-001293-dfaxj3bv	141	22	innate	innate	JJ
cord-001293-dfaxj3bv	141	23	immune	immune	JJ
cord-001293-dfaxj3bv	141	24	system	system	NN
cord-001293-dfaxj3bv	141	25	barriers	barrier	NNS
cord-001293-dfaxj3bv	141	26	.	.	.
cord-001293-dfaxj3bv	142	1	Intravascular	Intravascular	NNP
cord-001293-dfaxj3bv	142	2	catheters	catheter	NNS
cord-001293-dfaxj3bv	142	3	,	,	,
cord-001293-dfaxj3bv	142	4	endotracheal	endotracheal	NN
cord-001293-dfaxj3bv	142	5	tubes	tube	NNS
cord-001293-dfaxj3bv	142	6	with	with	IN
cord-001293-dfaxj3bv	142	7	consequently	consequently	RB
cord-001293-dfaxj3bv	142	8	increased	increase	VBN
cord-001293-dfaxj3bv	142	9	dead	dead	JJ
cord-001293-dfaxj3bv	142	10	space	space	NN
cord-001293-dfaxj3bv	142	11	,	,	,
cord-001293-dfaxj3bv	142	12	and	and	CC
cord-001293-dfaxj3bv	142	13	increased	increase	VBD
cord-001293-dfaxj3bv	142	14	gastric	gastric	JJ
cord-001293-dfaxj3bv	142	15	pH	ph	NN
cord-001293-dfaxj3bv	142	16	due	due	JJ
cord-001293-dfaxj3bv	142	17	to	to	IN
cord-001293-dfaxj3bv	143	1	peptic	peptic	JJ
cord-001293-dfaxj3bv	143	2	ulcer	ulcer	NN
cord-001293-dfaxj3bv	143	3	prophylaxis	prophylaxis	NN
cord-001293-dfaxj3bv	143	4	regimens	regimen	NNS
cord-001293-dfaxj3bv	143	5	are	be	VBP
cord-001293-dfaxj3bv	143	6	all	all	DT
cord-001293-dfaxj3bv	143	7	,	,	,
cord-001293-dfaxj3bv	143	8	along	along	IN
cord-001293-dfaxj3bv	143	9	with	with	IN
cord-001293-dfaxj3bv	143	10	broad	broad	JJ
cord-001293-dfaxj3bv	143	11	-	-	HYPH
cord-001293-dfaxj3bv	143	12	spectrum	spectrum	NN
cord-001293-dfaxj3bv	143	13	antibiotics	antibiotic	NNS
cord-001293-dfaxj3bv	143	14	,	,	,
cord-001293-dfaxj3bv	143	15	potent	potent	JJ
cord-001293-dfaxj3bv	143	16	promoters	promoter	NNS
cord-001293-dfaxj3bv	143	17	of	of	IN
cord-001293-dfaxj3bv	143	18	nosocomial	nosocomial	JJ
cord-001293-dfaxj3bv	143	19	infection	infection	NN
cord-001293-dfaxj3bv	143	20	.	.	.
cord-001293-dfaxj3bv	144	1	Post	Post	NNP
cord-001293-dfaxj3bv	144	2	-	-	NNS
cord-001293-dfaxj3bv	144	3	mortems	mortem	NNS
cord-001293-dfaxj3bv	144	4	(	(	-LRB-
cord-001293-dfaxj3bv	144	5	PMs	PMs	NNP
cord-001293-dfaxj3bv	144	6	)	)	-RRB-
cord-001293-dfaxj3bv	144	7	identifying	identify	VBG
cord-001293-dfaxj3bv	144	8	unresolved	unresolved	JJ
cord-001293-dfaxj3bv	144	9	infection	infection	NN
cord-001293-dfaxj3bv	144	10	foci	foci	NN
cord-001293-dfaxj3bv	144	11	are	be	VBP
cord-001293-dfaxj3bv	144	12	not	not	RB
cord-001293-dfaxj3bv	144	13	reliable	reliable	JJ
cord-001293-dfaxj3bv	144	14	proof	proof	NN
cord-001293-dfaxj3bv	144	15	that	that	IN
cord-001293-dfaxj3bv	144	16	patients	patient	NNS
cord-001293-dfaxj3bv	144	17	are	be	VBP
cord-001293-dfaxj3bv	144	18	dying	die	VBG
cord-001293-dfaxj3bv	144	19	of	of	IN
cord-001293-dfaxj3bv	144	20	sepsis	sepsis	NN
cord-001293-dfaxj3bv	144	21	.	.	.
cord-001293-dfaxj3bv	145	1	Pneumonia	pneumonia	NN
cord-001293-dfaxj3bv	145	2	is	be	VBZ
cord-001293-dfaxj3bv	145	3	frequently	frequently	RB
cord-001293-dfaxj3bv	145	4	present	present	JJ
cord-001293-dfaxj3bv	145	5	in	in	IN
cord-001293-dfaxj3bv	145	6	patients	patient	NNS
cord-001293-dfaxj3bv	145	7	in	in	IN
cord-001293-dfaxj3bv	145	8	whom	whom	WP
cord-001293-dfaxj3bv	145	9	supportive	supportive	JJ
cord-001293-dfaxj3bv	145	10	care	care	NN
cord-001293-dfaxj3bv	145	11	is	be	VBZ
cord-001293-dfaxj3bv	145	12	withdrawn	withdraw	VBN
cord-001293-dfaxj3bv	145	13	due	due	IN
cord-001293-dfaxj3bv	145	14	to	to	IN
cord-001293-dfaxj3bv	145	15	failure	failure	NN
cord-001293-dfaxj3bv	145	16	to	to	TO
cord-001293-dfaxj3bv	145	17	thrive	thrive	VB
cord-001293-dfaxj3bv	145	18	.	.	.
cord-001293-dfaxj3bv	146	1	Where	where	WRB
cord-001293-dfaxj3bv	146	2	pneumonia	pneumonia	NN
cord-001293-dfaxj3bv	146	3	has	have	VBZ
cord-001293-dfaxj3bv	146	4	been	be	VBN
cord-001293-dfaxj3bv	146	5	found	find	VBN
cord-001293-dfaxj3bv	146	6	more	more	RBR
cord-001293-dfaxj3bv	146	7	frequently	frequently	RB
cord-001293-dfaxj3bv	146	8	at	at	IN
cord-001293-dfaxj3bv	146	9	PM	pm	NN
cord-001293-dfaxj3bv	146	10	than	than	IN
cord-001293-dfaxj3bv	146	11	was	be	VBD
cord-001293-dfaxj3bv	146	12	appreciated	appreciate	VBN
cord-001293-dfaxj3bv	146	13	ante	ante	NN
cord-001293-dfaxj3bv	146	14	-	-	HYPH
cord-001293-dfaxj3bv	146	15	mortem	mortem	NN
cord-001293-dfaxj3bv	146	16	,	,	,
cord-001293-dfaxj3bv	146	17	the	the	DT
cord-001293-dfaxj3bv	146	18	extent	extent	NN
cord-001293-dfaxj3bv	146	19	of	of	IN
cord-001293-dfaxj3bv	146	20	pulmonary	pulmonary	JJ
cord-001293-dfaxj3bv	146	21	involvement	involvement	NN
cord-001293-dfaxj3bv	146	22	was	be	VBD
cord-001293-dfaxj3bv	146	23	not	not	RB
cord-001293-dfaxj3bv	146	24	quantified	quantify	VBN
cord-001293-dfaxj3bv	146	25	[	[	-LRB-
cord-001293-dfaxj3bv	146	26	73	73	CD
cord-001293-dfaxj3bv	146	27	]	]	-RRB-
cord-001293-dfaxj3bv	146	28	.	.	.
cord-001293-dfaxj3bv	147	1	In	in	IN
cord-001293-dfaxj3bv	147	2	this	this	DT
cord-001293-dfaxj3bv	147	3	series	series	NN
cord-001293-dfaxj3bv	147	4	,	,	,
cord-001293-dfaxj3bv	147	5	there	there	EX
cord-001293-dfaxj3bv	147	6	was	be	VBD
cord-001293-dfaxj3bv	147	7	clear	clear	JJ
cord-001293-dfaxj3bv	147	8	agreement	agreement	NN
cord-001293-dfaxj3bv	147	9	by	by	IN
cord-001293-dfaxj3bv	147	10	clinical	clinical	JJ
cord-001293-dfaxj3bv	147	11	and	and	CC
cord-001293-dfaxj3bv	147	12	PM	pm	NN
cord-001293-dfaxj3bv	147	13	assessment	assessment	NN
cord-001293-dfaxj3bv	147	14	that	that	WDT
cord-001293-dfaxj3bv	147	15	MOF	MOF	NNP
cord-001293-dfaxj3bv	147	16	was	be	VBD
cord-001293-dfaxj3bv	147	17	the	the	DT
cord-001293-dfaxj3bv	147	18	commonest	common	JJS
cord-001293-dfaxj3bv	147	19	cause	cause	NN
cord-001293-dfaxj3bv	147	20	of	of	IN
cord-001293-dfaxj3bv	147	21	death	death	NN
cord-001293-dfaxj3bv	147	22	[	[	-LRB-
cord-001293-dfaxj3bv	147	23	73	73	CD
cord-001293-dfaxj3bv	147	24	]	]	-RRB-
cord-001293-dfaxj3bv	147	25	.	.	.
cord-001293-dfaxj3bv	148	1	These	these	DT
cord-001293-dfaxj3bv	148	2	data	datum	NNS
cord-001293-dfaxj3bv	148	3	call	call	VBP
cord-001293-dfaxj3bv	148	4	into	into	IN
cord-001293-dfaxj3bv	148	5	question	question	NN
cord-001293-dfaxj3bv	148	6	the	the	DT
cord-001293-dfaxj3bv	148	7	relevance	relevance	NN
cord-001293-dfaxj3bv	148	8	of	of	IN
cord-001293-dfaxj3bv	148	9	unresolved	unresolved	JJ
cord-001293-dfaxj3bv	148	10	,	,	,
cord-001293-dfaxj3bv	148	11	PM	pm	NN
cord-001293-dfaxj3bv	148	12	infection	infection	NN
cord-001293-dfaxj3bv	148	13	in	in	IN
cord-001293-dfaxj3bv	148	14	patients	patient	NNS
cord-001293-dfaxj3bv	148	15	dying	die	VBG
cord-001293-dfaxj3bv	148	16	in	in	IN
cord-001293-dfaxj3bv	148	17	the	the	DT
cord-001293-dfaxj3bv	148	18	ICU	ICU	NNP
cord-001293-dfaxj3bv	148	19	as	as	IN
cord-001293-dfaxj3bv	148	20	a	a	DT
cord-001293-dfaxj3bv	148	21	direct	direct	JJ
cord-001293-dfaxj3bv	148	22	indicator	indicator	NN
cord-001293-dfaxj3bv	148	23	of	of	IN
cord-001293-dfaxj3bv	148	24	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	148	25	following	follow	VBG
cord-001293-dfaxj3bv	148	26	as	as	IN
cord-001293-dfaxj3bv	148	27	a	a	DT
cord-001293-dfaxj3bv	148	28	direct	direct	JJ
cord-001293-dfaxj3bv	148	29	consequence	consequence	NN
cord-001293-dfaxj3bv	148	30	of	of	IN
cord-001293-dfaxj3bv	148	31	previous	previous	JJ
cord-001293-dfaxj3bv	148	32	sepsis	sepsis	NN
cord-001293-dfaxj3bv	148	33	.	.	.
cord-001293-dfaxj3bv	149	1	If	if	IN
cord-001293-dfaxj3bv	149	2	the	the	DT
cord-001293-dfaxj3bv	149	3	patients	patient	NNS
cord-001293-dfaxj3bv	149	4	die	die	VBP
cord-001293-dfaxj3bv	149	5	with	with	IN
cord-001293-dfaxj3bv	149	6	infectious	infectious	JJ
cord-001293-dfaxj3bv	149	7	foci	focus	NNS
cord-001293-dfaxj3bv	149	8	and	and	CC
cord-001293-dfaxj3bv	149	9	altered	alter	VBN
cord-001293-dfaxj3bv	149	10	immune	immune	JJ
cord-001293-dfaxj3bv	149	11	status	status	NN
cord-001293-dfaxj3bv	149	12	,	,	,
cord-001293-dfaxj3bv	149	13	it	-PRON-	PRP
cord-001293-dfaxj3bv	149	14	does	do	VBZ
cord-001293-dfaxj3bv	149	15	not	not	RB
cord-001293-dfaxj3bv	149	16	mean	mean	VB
cord-001293-dfaxj3bv	149	17	they	-PRON-	PRP
cord-001293-dfaxj3bv	149	18	die	die	VBP
cord-001293-dfaxj3bv	149	19	because	because	IN
cord-001293-dfaxj3bv	149	20	of	of	IN
cord-001293-dfaxj3bv	149	21	them	-PRON-	PRP
cord-001293-dfaxj3bv	149	22	.	.	.
cord-001293-dfaxj3bv	150	1	Because	because	IN
cord-001293-dfaxj3bv	150	2	of	of	IN
cord-001293-dfaxj3bv	150	3	the	the	DT
cord-001293-dfaxj3bv	150	4	monocyte	monocyte	NNP
cord-001293-dfaxj3bv	150	5	deactivation	deactivation	NN
cord-001293-dfaxj3bv	150	6	in	in	IN
cord-001293-dfaxj3bv	150	7	sepsis	sepsis	NN
cord-001293-dfaxj3bv	150	8	,	,	,
cord-001293-dfaxj3bv	150	9	it	-PRON-	PRP
cord-001293-dfaxj3bv	150	10	was	be	VBD
cord-001293-dfaxj3bv	150	11	proposed	propose	VBN
cord-001293-dfaxj3bv	150	12	to	to	TO
cord-001293-dfaxj3bv	150	13	restore	restore	VB
cord-001293-dfaxj3bv	150	14	it	-PRON-	PRP
cord-001293-dfaxj3bv	150	15	with	with	IN
cord-001293-dfaxj3bv	150	16	the	the	DT
cord-001293-dfaxj3bv	150	17	use	use	NN
cord-001293-dfaxj3bv	150	18	of	of	IN
cord-001293-dfaxj3bv	150	19	either	either	DT
cord-001293-dfaxj3bv	150	20	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	150	21	or	or	CC
cord-001293-dfaxj3bv	150	22	GM	GM	NNP
cord-001293-dfaxj3bv	150	23	-	-	HYPH
cord-001293-dfaxj3bv	150	24	CSF	CSF	NNP
cord-001293-dfaxj3bv	150	25	,	,	,
cord-001293-dfaxj3bv	150	26	two	two	CD
cord-001293-dfaxj3bv	150	27	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	150	28	that	that	WDT
cord-001293-dfaxj3bv	150	29	counteract	counteract	VBP
cord-001293-dfaxj3bv	150	30	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	150	31	tolerance	tolerance	NN
cord-001293-dfaxj3bv	150	32	.	.	.
cord-001293-dfaxj3bv	151	1	The	the	DT
cord-001293-dfaxj3bv	151	2	first	first	JJ
cord-001293-dfaxj3bv	151	3	attempt	attempt	NN
cord-001293-dfaxj3bv	151	4	was	be	VBD
cord-001293-dfaxj3bv	151	5	successfully	successfully	RB
cord-001293-dfaxj3bv	151	6	performed	perform	VBN
cord-001293-dfaxj3bv	151	7	in	in	IN
cord-001293-dfaxj3bv	151	8	nine	nine	CD
cord-001293-dfaxj3bv	151	9	septic	septic	JJ
cord-001293-dfaxj3bv	151	10	patients	patient	NNS
cord-001293-dfaxj3bv	151	11	who	who	WP
cord-001293-dfaxj3bv	151	12	received	receive	VBD
cord-001293-dfaxj3bv	151	13	subcutaneous	subcutaneous	JJ
cord-001293-dfaxj3bv	151	14	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	151	15	that	that	WDT
cord-001293-dfaxj3bv	151	16	restored	restore	VBD
cord-001293-dfaxj3bv	151	17	ex	ex	FW
cord-001293-dfaxj3bv	151	18	vivo	vivo	NN
cord-001293-dfaxj3bv	151	19	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	151	20	production	production	NN
cord-001293-dfaxj3bv	151	21	and	and	CC
cord-001293-dfaxj3bv	151	22	HLA	HLA	NNP
cord-001293-dfaxj3bv	151	23	-	-	HYPH
cord-001293-dfaxj3bv	151	24	DR	DR	NNP
cord-001293-dfaxj3bv	151	25	expression	expression	NN
cord-001293-dfaxj3bv	151	26	by	by	IN
cord-001293-dfaxj3bv	151	27	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	151	28	[	[	-LRB-
cord-001293-dfaxj3bv	151	29	74	74	CD
cord-001293-dfaxj3bv	151	30	]	]	-RRB-
cord-001293-dfaxj3bv	151	31	.	.	.
cord-001293-dfaxj3bv	152	1	The	the	DT
cord-001293-dfaxj3bv	152	2	authors	author	NNS
cord-001293-dfaxj3bv	152	3	claimed	claim	VBD
cord-001293-dfaxj3bv	152	4	that	that	IN
cord-001293-dfaxj3bv	152	5	overall	overall	JJ
cord-001293-dfaxj3bv	152	6	mortality	mortality	NN
cord-001293-dfaxj3bv	152	7	was	be	VBD
cord-001293-dfaxj3bv	152	8	lower	low	JJR
cord-001293-dfaxj3bv	152	9	in	in	IN
cord-001293-dfaxj3bv	152	10	the	the	DT
cord-001293-dfaxj3bv	152	11	treated	treat	VBN
cord-001293-dfaxj3bv	152	12	group	group	NN
cord-001293-dfaxj3bv	152	13	compared	compare	VBN
cord-001293-dfaxj3bv	152	14	with	with	IN
cord-001293-dfaxj3bv	152	15	historical	historical	JJ
cord-001293-dfaxj3bv	152	16	controls	control	NNS
cord-001293-dfaxj3bv	152	17	.	.	.
cord-001293-dfaxj3bv	153	1	In	in	IN
cord-001293-dfaxj3bv	153	2	mechanically	mechanically	RB
cord-001293-dfaxj3bv	153	3	ventilated	ventilate	VBN
cord-001293-dfaxj3bv	153	4	trauma	trauma	NN
cord-001293-dfaxj3bv	153	5	patients	patient	NNS
cord-001293-dfaxj3bv	153	6	,	,	,
cord-001293-dfaxj3bv	153	7	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	153	8	was	be	VBD
cord-001293-dfaxj3bv	153	9	aerosolized	aerosolize	VBN
cord-001293-dfaxj3bv	153	10	.	.	.
cord-001293-dfaxj3bv	154	1	However	however	RB
cord-001293-dfaxj3bv	154	2	,	,	,
cord-001293-dfaxj3bv	154	3	in	in	IN
cord-001293-dfaxj3bv	154	4	a	a	DT
cord-001293-dfaxj3bv	154	5	previous	previous	JJ
cord-001293-dfaxj3bv	154	6	phase	phase	NN
cord-001293-dfaxj3bv	154	7	III	iii	CD
cord-001293-dfaxj3bv	154	8	study	study	NN
cord-001293-dfaxj3bv	154	9	in	in	IN
cord-001293-dfaxj3bv	154	10	burn	burn	NN
cord-001293-dfaxj3bv	154	11	patients	patient	NNS
cord-001293-dfaxj3bv	154	12	,	,	,
cord-001293-dfaxj3bv	154	13	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	154	14	had	have	VBD
cord-001293-dfaxj3bv	154	15	failed	fail	VBN
cord-001293-dfaxj3bv	154	16	to	to	TO
cord-001293-dfaxj3bv	154	17	protect	protect	VB
cord-001293-dfaxj3bv	154	18	patients	patient	NNS
cord-001293-dfaxj3bv	154	19	from	from	IN
cord-001293-dfaxj3bv	154	20	infection	infection	NN
cord-001293-dfaxj3bv	154	21	or	or	CC
cord-001293-dfaxj3bv	154	22	decrease	decrease	NN
cord-001293-dfaxj3bv	154	23	mortality	mortality	NN
cord-001293-dfaxj3bv	154	24	[	[	-LRB-
cord-001293-dfaxj3bv	154	25	75	75	CD
cord-001293-dfaxj3bv	154	26	]	]	-RRB-
cord-001293-dfaxj3bv	154	27	.	.	.
cord-001293-dfaxj3bv	155	1	We	-PRON-	PRP
cord-001293-dfaxj3bv	155	2	must	must	MD
cord-001293-dfaxj3bv	155	3	recall	recall	VB
cord-001293-dfaxj3bv	155	4	that	that	IN
cord-001293-dfaxj3bv	155	5	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	155	6	injection	injection	NN
cord-001293-dfaxj3bv	155	7	increases	increase	VBZ
cord-001293-dfaxj3bv	155	8	mortality	mortality	NN
cord-001293-dfaxj3bv	155	9	in	in	IN
cord-001293-dfaxj3bv	155	10	animal	animal	NN
cord-001293-dfaxj3bv	155	11	models	model	NNS
cord-001293-dfaxj3bv	155	12	of	of	IN
cord-001293-dfaxj3bv	155	13	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	155	14	infection	infection	NN
cord-001293-dfaxj3bv	155	15	[	[	-LRB-
cord-001293-dfaxj3bv	155	16	15	15	CD
cord-001293-dfaxj3bv	155	17	]	]	-RRB-
cord-001293-dfaxj3bv	155	18	.	.	.
cord-001293-dfaxj3bv	156	1	All	all	RB
cord-001293-dfaxj3bv	156	2	together	together	RB
cord-001293-dfaxj3bv	156	3	,	,	,
cord-001293-dfaxj3bv	156	4	these	these	DT
cord-001293-dfaxj3bv	156	5	data	datum	NNS
cord-001293-dfaxj3bv	156	6	have	have	VBP
cord-001293-dfaxj3bv	156	7	limited	limit	VBN
cord-001293-dfaxj3bv	156	8	the	the	DT
cord-001293-dfaxj3bv	156	9	routine	routine	JJ
cord-001293-dfaxj3bv	156	10	use	use	NN
cord-001293-dfaxj3bv	156	11	of	of	IN
cord-001293-dfaxj3bv	156	12	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	156	13	in	in	IN
cord-001293-dfaxj3bv	156	14	ICU	ICU	NNP
cord-001293-dfaxj3bv	156	15	patients	patient	NNS
cord-001293-dfaxj3bv	156	16	,	,	,
cord-001293-dfaxj3bv	156	17	although	although	IN
cord-001293-dfaxj3bv	156	18	a	a	DT
cord-001293-dfaxj3bv	156	19	Dutch	dutch	JJ
cord-001293-dfaxj3bv	156	20	clinical	clinical	JJ
cord-001293-dfaxj3bv	156	21	trial	trial	NN
cord-001293-dfaxj3bv	156	22	is	be	VBZ
cord-001293-dfaxj3bv	156	23	ongoing	ongoing	JJ
cord-001293-dfaxj3bv	156	24	.	.	.
cord-001293-dfaxj3bv	157	1	GM	GM	NNP
cord-001293-dfaxj3bv	157	2	-	-	HYPH
cord-001293-dfaxj3bv	157	3	CSF	CSF	NNP
cord-001293-dfaxj3bv	157	4	has	have	VBZ
cord-001293-dfaxj3bv	157	5	been	be	VBN
cord-001293-dfaxj3bv	157	6	demonstrated	demonstrate	VBN
cord-001293-dfaxj3bv	157	7	to	to	TO
cord-001293-dfaxj3bv	157	8	be	be	VB
cord-001293-dfaxj3bv	157	9	able	able	JJ
cord-001293-dfaxj3bv	157	10	to	to	TO
cord-001293-dfaxj3bv	157	11	restore	restore	VB
cord-001293-dfaxj3bv	157	12	some	some	DT
cord-001293-dfaxj3bv	157	13	immune	immune	JJ
cord-001293-dfaxj3bv	157	14	status	status	NN
cord-001293-dfaxj3bv	157	15	parameters	parameter	NNS
cord-001293-dfaxj3bv	157	16	.	.	.
cord-001293-dfaxj3bv	158	1	However	however	RB
cord-001293-dfaxj3bv	158	2	,	,	,
cord-001293-dfaxj3bv	158	3	a	a	DT
cord-001293-dfaxj3bv	158	4	metaanalysis	metaanalysis	NN
cord-001293-dfaxj3bv	158	5	concluded	conclude	VBD
cord-001293-dfaxj3bv	158	6	that	that	IN
cord-001293-dfaxj3bv	158	7	GM	GM	NNP
cord-001293-dfaxj3bv	158	8	-	-	HYPH
cord-001293-dfaxj3bv	158	9	CSF	CSF	NNP
cord-001293-dfaxj3bv	158	10	did	do	VBD
cord-001293-dfaxj3bv	158	11	not	not	RB
cord-001293-dfaxj3bv	158	12	significantly	significantly	RB
cord-001293-dfaxj3bv	158	13	reduce	reduce	VB
cord-001293-dfaxj3bv	158	14	in	in	IN
cord-001293-dfaxj3bv	158	15	-	-	HYPH
cord-001293-dfaxj3bv	158	16	hospital	hospital	NN
cord-001293-dfaxj3bv	158	17	mortality	mortality	NN
cord-001293-dfaxj3bv	158	18	,	,	,
cord-001293-dfaxj3bv	158	19	although	although	IN
cord-001293-dfaxj3bv	158	20	it	-PRON-	PRP
cord-001293-dfaxj3bv	158	21	significantly	significantly	RB
cord-001293-dfaxj3bv	158	22	increased	increase	VBD
cord-001293-dfaxj3bv	158	23	infection	infection	NN
cord-001293-dfaxj3bv	158	24	recovery	recovery	NN
cord-001293-dfaxj3bv	158	25	[	[	-LRB-
cord-001293-dfaxj3bv	158	26	76	76	CD
cord-001293-dfaxj3bv	158	27	]	]	-RRB-
cord-001293-dfaxj3bv	158	28	.	.	.
cord-001293-dfaxj3bv	159	1	Although	although	IN
cord-001293-dfaxj3bv	159	2	no	no	DT
cord-001293-dfaxj3bv	159	3	adverse	adverse	JJ
cord-001293-dfaxj3bv	159	4	effects	effect	NNS
cord-001293-dfaxj3bv	159	5	were	be	VBD
cord-001293-dfaxj3bv	159	6	reported	report	VBN
cord-001293-dfaxj3bv	159	7	,	,	,
cord-001293-dfaxj3bv	159	8	it	-PRON-	PRP
cord-001293-dfaxj3bv	159	9	is	be	VBZ
cord-001293-dfaxj3bv	159	10	worth	worth	JJ
cord-001293-dfaxj3bv	159	11	recalling	recall	VBG
cord-001293-dfaxj3bv	159	12	a	a	DT
cord-001293-dfaxj3bv	159	13	case	case	NN
cord-001293-dfaxj3bv	159	14	report	report	NN
cord-001293-dfaxj3bv	159	15	of	of	IN
cord-001293-dfaxj3bv	159	16	a	a	DT
cord-001293-dfaxj3bv	159	17	patient	patient	NN
cord-001293-dfaxj3bv	159	18	who	who	WP
cord-001293-dfaxj3bv	159	19	developed	develop	VBD
cord-001293-dfaxj3bv	159	20	a	a	DT
cord-001293-dfaxj3bv	159	21	fatal	fatal	JJ
cord-001293-dfaxj3bv	159	22	adult	adult	NN
cord-001293-dfaxj3bv	159	23	respiratory	respiratory	JJ
cord-001293-dfaxj3bv	159	24	distress	distress	NN
cord-001293-dfaxj3bv	159	25	syndrome	syndrome	NN
cord-001293-dfaxj3bv	159	26	after	after	IN
cord-001293-dfaxj3bv	159	27	GM	GM	NNP
cord-001293-dfaxj3bv	159	28	-	-	HYPH
cord-001293-dfaxj3bv	159	29	CSF	csf	NN
cord-001293-dfaxj3bv	159	30	treatment	treatment	NN
cord-001293-dfaxj3bv	159	31	[	[	-LRB-
cord-001293-dfaxj3bv	159	32	77	77	CD
cord-001293-dfaxj3bv	159	33	]	]	-RRB-
cord-001293-dfaxj3bv	159	34	.	.	.
cord-001293-dfaxj3bv	160	1	In	in	IN
cord-001293-dfaxj3bv	160	2	animal	animal	NN
cord-001293-dfaxj3bv	160	3	models	model	NNS
cord-001293-dfaxj3bv	160	4	,	,	,
cord-001293-dfaxj3bv	160	5	GM	GM	NNP
cord-001293-dfaxj3bv	160	6	-	-	HYPH
cord-001293-dfaxj3bv	160	7	CSF	CSF	NNP
cord-001293-dfaxj3bv	160	8	favors	favor	VBZ
cord-001293-dfaxj3bv	160	9	LPS	LPS	NNP
cord-001293-dfaxj3bv	160	10	-	-	HYPH
cord-001293-dfaxj3bv	160	11	induced	induce	VBN
cord-001293-dfaxj3bv	160	12	lung	lung	NN
cord-001293-dfaxj3bv	160	13	inflammation	inflammation	NN
cord-001293-dfaxj3bv	160	14	,	,	,
cord-001293-dfaxj3bv	160	15	amplifying	amplify	VBG
cord-001293-dfaxj3bv	160	16	LPS	LPS	NNP
cord-001293-dfaxj3bv	160	17	-	-	HYPH
cord-001293-dfaxj3bv	160	18	induced	induce	VBN
cord-001293-dfaxj3bv	160	19	bronchoconstriction	bronchoconstriction	NN
cord-001293-dfaxj3bv	160	20	[	[	-LRB-
cord-001293-dfaxj3bv	160	21	78	78	CD
cord-001293-dfaxj3bv	160	22	]	]	-RRB-
cord-001293-dfaxj3bv	160	23	.	.	.
cord-001293-dfaxj3bv	161	1	GM	GM	NNP
cord-001293-dfaxj3bv	161	2	-	-	HYPH
cord-001293-dfaxj3bv	161	3	CSF	csf	NN
cord-001293-dfaxj3bv	161	4	favors	favor	VBZ
cord-001293-dfaxj3bv	161	5	production	production	NN
cord-001293-dfaxj3bv	161	6	of	of	IN
cord-001293-dfaxj3bv	161	7	TNF	TNF	NNP
cord-001293-dfaxj3bv	161	8	and	and	CC
cord-001293-dfaxj3bv	162	1	IL-1	IL-1	NNP
cord-001293-dfaxj3bv	162	2	.	.	.
cord-001293-dfaxj3bv	163	1	In	in	IN
cord-001293-dfaxj3bv	163	2	a	a	DT
cord-001293-dfaxj3bv	163	3	recent	recent	JJ
cord-001293-dfaxj3bv	163	4	study	study	NN
cord-001293-dfaxj3bv	163	5	,	,	,
cord-001293-dfaxj3bv	163	6	it	-PRON-	PRP
cord-001293-dfaxj3bv	163	7	was	be	VBD
cord-001293-dfaxj3bv	163	8	confirmed	confirm	VBN
cord-001293-dfaxj3bv	163	9	that	that	IN
cord-001293-dfaxj3bv	163	10	GM	GM	NNP
cord-001293-dfaxj3bv	163	11	-	-	HYPH
cord-001293-dfaxj3bv	163	12	CSF	CSF	NNP
cord-001293-dfaxj3bv	163	13	synergizes	synergize	VBZ
cord-001293-dfaxj3bv	163	14	with	with	IN
cord-001293-dfaxj3bv	163	15	LPS	LPS	NNP
cord-001293-dfaxj3bv	163	16	,	,	,
cord-001293-dfaxj3bv	163	17	promoting	promote	VBG
cord-001293-dfaxj3bv	163	18	IL-1β	IL-1β	JJR
cord-001293-dfaxj3bv	163	19	secretion	secretion	NN
cord-001293-dfaxj3bv	163	20	[	[	-LRB-
cord-001293-dfaxj3bv	163	21	79	79	CD
cord-001293-dfaxj3bv	163	22	]	]	-RRB-
cord-001293-dfaxj3bv	163	23	.	.	.
cord-001293-dfaxj3bv	164	1	Lethal	lethal	JJ
cord-001293-dfaxj3bv	164	2	injection	injection	NN
cord-001293-dfaxj3bv	164	3	of	of	IN
cord-001293-dfaxj3bv	164	4	LPS	LPS	NNP
cord-001293-dfaxj3bv	164	5	in	in	IN
cord-001293-dfaxj3bv	164	6	GM	GM	NNP
cord-001293-dfaxj3bv	164	7	-	-	HYPH
cord-001293-dfaxj3bv	164	8	CSF	CSF	NNP
cord-001293-dfaxj3bv	164	9	receptor	receptor	NN
cord-001293-dfaxj3bv	164	10	KO	KO	NNP
cord-001293-dfaxj3bv	164	11	mice	mouse	NNS
cord-001293-dfaxj3bv	164	12	led	lead	VBD
cord-001293-dfaxj3bv	164	13	to	to	IN
cord-001293-dfaxj3bv	164	14	far	far	RB
cord-001293-dfaxj3bv	164	15	lower	low	JJR
cord-001293-dfaxj3bv	164	16	mortality	mortality	NN
cord-001293-dfaxj3bv	164	17	among	among	IN
cord-001293-dfaxj3bv	164	18	these	these	DT
cord-001293-dfaxj3bv	164	19	mice	mouse	NNS
cord-001293-dfaxj3bv	164	20	as	as	IN
cord-001293-dfaxj3bv	164	21	compared	compare	VBN
cord-001293-dfaxj3bv	164	22	to	to	IN
cord-001293-dfaxj3bv	164	23	wild	wild	JJ
cord-001293-dfaxj3bv	164	24	type	type	NN
cord-001293-dfaxj3bv	164	25	mice	mouse	NNS
cord-001293-dfaxj3bv	164	26	.	.	.
cord-001293-dfaxj3bv	165	1	Given	give	VBN
cord-001293-dfaxj3bv	165	2	all	all	PDT
cord-001293-dfaxj3bv	165	3	the	the	DT
cord-001293-dfaxj3bv	165	4	efforts	effort	NNS
cord-001293-dfaxj3bv	165	5	made	make	VBN
cord-001293-dfaxj3bv	165	6	by	by	IN
cord-001293-dfaxj3bv	165	7	some	some	DT
cord-001293-dfaxj3bv	165	8	authors	author	NNS
cord-001293-dfaxj3bv	165	9	to	to	TO
cord-001293-dfaxj3bv	165	10	convince	convince	VB
cord-001293-dfaxj3bv	165	11	the	the	DT
cord-001293-dfaxj3bv	165	12	scientific	scientific	JJ
cord-001293-dfaxj3bv	165	13	community	community	NN
cord-001293-dfaxj3bv	165	14	of	of	IN
cord-001293-dfaxj3bv	165	15	the	the	DT
cord-001293-dfaxj3bv	165	16	use	use	NN
cord-001293-dfaxj3bv	165	17	of	of	IN
cord-001293-dfaxj3bv	165	18	GM	GM	NNP
cord-001293-dfaxj3bv	165	19	-	-	HYPH
cord-001293-dfaxj3bv	165	20	CSF	CSF	NNP
cord-001293-dfaxj3bv	165	21	,	,	,
cord-001293-dfaxj3bv	165	22	it	-PRON-	PRP
cord-001293-dfaxj3bv	165	23	is	be	VBZ
cord-001293-dfaxj3bv	165	24	challenging	challenge	VBG
cord-001293-dfaxj3bv	165	25	to	to	TO
cord-001293-dfaxj3bv	165	26	read	read	VB
cord-001293-dfaxj3bv	165	27	the	the	DT
cord-001293-dfaxj3bv	165	28	conclusion	conclusion	NN
cord-001293-dfaxj3bv	165	29	of	of	IN
cord-001293-dfaxj3bv	165	30	this	this	DT
cord-001293-dfaxj3bv	165	31	present	present	JJ
cord-001293-dfaxj3bv	165	32	paper	paper	NN
cord-001293-dfaxj3bv	165	33	given	give	VBN
cord-001293-dfaxj3bv	165	34	that	that	IN
cord-001293-dfaxj3bv	165	35	GM	GM	NNP
cord-001293-dfaxj3bv	165	36	-	-	HYPH
cord-001293-dfaxj3bv	165	37	CSF	CSF	NNP
cord-001293-dfaxj3bv	165	38	has	have	VBZ
cord-001293-dfaxj3bv	165	39	been	be	VBN
cord-001293-dfaxj3bv	165	40	previously	previously	RB
cord-001293-dfaxj3bv	165	41	underestimated	underestimate	VBN
cord-001293-dfaxj3bv	165	42	as	as	IN
cord-001293-dfaxj3bv	165	43	a	a	DT
cord-001293-dfaxj3bv	165	44	target	target	NN
cord-001293-dfaxj3bv	165	45	for	for	IN
cord-001293-dfaxj3bv	165	46	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	165	47	intervention	intervention	NN
cord-001293-dfaxj3bv	165	48	in	in	IN
cord-001293-dfaxj3bv	165	49	many	many	JJ
cord-001293-dfaxj3bv	165	50	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	165	51	infections	infection	NNS
cord-001293-dfaxj3bv	165	52	and	and	CC
cord-001293-dfaxj3bv	165	53	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	165	54	disorders	disorder	NNS
cord-001293-dfaxj3bv	165	55	associated	associate	VBN
cord-001293-dfaxj3bv	165	56	with	with	IN
cord-001293-dfaxj3bv	165	57	the	the	DT
cord-001293-dfaxj3bv	165	58	production	production	NN
cord-001293-dfaxj3bv	165	59	of	of	IN
cord-001293-dfaxj3bv	165	60	IL-1β	il-1β	NN
cord-001293-dfaxj3bv	165	61	.	.	.
cord-001293-dfaxj3bv	166	1	IL-7	IL-7	NNP
cord-001293-dfaxj3bv	166	2	is	be	VBZ
cord-001293-dfaxj3bv	166	3	another	another	DT
cord-001293-dfaxj3bv	166	4	cytokine	cytokine	NN
cord-001293-dfaxj3bv	166	5	that	that	WDT
cord-001293-dfaxj3bv	166	6	is	be	VBZ
cord-001293-dfaxj3bv	166	7	promoted	promote	VBN
cord-001293-dfaxj3bv	166	8	for	for	IN
cord-001293-dfaxj3bv	166	9	the	the	DT
cord-001293-dfaxj3bv	166	10	treatment	treatment	NN
cord-001293-dfaxj3bv	166	11	of	of	IN
cord-001293-dfaxj3bv	166	12	sepsis	sepsis	NN
cord-001293-dfaxj3bv	166	13	and	and	CC
cord-001293-dfaxj3bv	166	14	that	that	DT
cord-001293-dfaxj3bv	166	15	is	be	VBZ
cord-001293-dfaxj3bv	166	16	supported	support	VBN
cord-001293-dfaxj3bv	166	17	by	by	IN
cord-001293-dfaxj3bv	166	18	murine	murine	JJ
cord-001293-dfaxj3bv	166	19	and	and	CC
cord-001293-dfaxj3bv	166	20	human	human	JJ
cord-001293-dfaxj3bv	166	21	ex	ex	FW
cord-001293-dfaxj3bv	166	22	vivo	vivo	NN
cord-001293-dfaxj3bv	166	23	tissue	tissue	NN
cord-001293-dfaxj3bv	166	24	data	datum	NNS
cord-001293-dfaxj3bv	166	25	[	[	-LRB-
cord-001293-dfaxj3bv	166	26	1	1	CD
cord-001293-dfaxj3bv	166	27	,	,	,
cord-001293-dfaxj3bv	166	28	80	80	CD
cord-001293-dfaxj3bv	166	29	]	]	-RRB-
cord-001293-dfaxj3bv	166	30	.	.	.
cord-001293-dfaxj3bv	167	1	One	one	PRP
cord-001293-dfaxj3bv	167	2	can	can	MD
cord-001293-dfaxj3bv	167	3	conjecture	conjecture	VB
cord-001293-dfaxj3bv	167	4	that	that	IN
cord-001293-dfaxj3bv	167	5	systemic	systemic	JJ
cord-001293-dfaxj3bv	167	6	treatment	treatment	NN
cord-001293-dfaxj3bv	167	7	with	with	IN
cord-001293-dfaxj3bv	167	8	IL-7	IL-7	NNP
cord-001293-dfaxj3bv	167	9	may	may	MD
cord-001293-dfaxj3bv	167	10	act	act	VB
cord-001293-dfaxj3bv	167	11	in	in	IN
cord-001293-dfaxj3bv	167	12	undesired	undesired	JJ
cord-001293-dfaxj3bv	167	13	places	place	NNS
cord-001293-dfaxj3bv	167	14	,	,	,
cord-001293-dfaxj3bv	167	15	as	as	IN
cord-001293-dfaxj3bv	167	16	illustrated	illustrate	VBN
cord-001293-dfaxj3bv	167	17	by	by	IN
cord-001293-dfaxj3bv	167	18	the	the	DT
cord-001293-dfaxj3bv	167	19	following	following	NN
cord-001293-dfaxj3bv	167	20	:	:	:
cord-001293-dfaxj3bv	167	21	IL-7	IL-7	NNP
cord-001293-dfaxj3bv	167	22	worsens	worsen	VBZ
cord-001293-dfaxj3bv	167	23	graft	graft	NN
cord-001293-dfaxj3bv	167	24	-	-	HYPH
cord-001293-dfaxj3bv	167	25	versus	versus	IN
cord-001293-dfaxj3bv	167	26	-	-	HYPH
cord-001293-dfaxj3bv	167	27	host	host	NN
cord-001293-dfaxj3bv	167	28	-	-	HYPH
cord-001293-dfaxj3bv	167	29	induced	induce	VBN
cord-001293-dfaxj3bv	167	30	tissue	tissue	NN
cord-001293-dfaxj3bv	167	31	inflammation	inflammation	NN
cord-001293-dfaxj3bv	167	32	[	[	-LRB-
cord-001293-dfaxj3bv	167	33	81	81	CD
cord-001293-dfaxj3bv	167	34	]	]	-RRB-
cord-001293-dfaxj3bv	167	35	;	;	:
cord-001293-dfaxj3bv	167	36	favors	favor	VBZ
cord-001293-dfaxj3bv	167	37	inflammation	inflammation	NN
cord-001293-dfaxj3bv	167	38	in	in	IN
cord-001293-dfaxj3bv	167	39	colitis	colitis	NN
cord-001293-dfaxj3bv	167	40	[	[	-LRB-
cord-001293-dfaxj3bv	167	41	82	82	CD
cord-001293-dfaxj3bv	167	42	]	]	-RRB-
cord-001293-dfaxj3bv	167	43	,	,	,
cord-001293-dfaxj3bv	167	44	contributes	contribute	VBZ
cord-001293-dfaxj3bv	167	45	to	to	IN
cord-001293-dfaxj3bv	167	46	arthritis	arthritis	NN
cord-001293-dfaxj3bv	167	47	severity	severity	NN
cord-001293-dfaxj3bv	167	48	[	[	-LRB-
cord-001293-dfaxj3bv	167	49	83	83	CD
cord-001293-dfaxj3bv	167	50	]	]	-RRB-
cord-001293-dfaxj3bv	167	51	;	;	:
cord-001293-dfaxj3bv	167	52	upregulates	upregulate	VBZ
cord-001293-dfaxj3bv	167	53	chemokines	chemokine	NNS
cord-001293-dfaxj3bv	167	54	,	,	,
cord-001293-dfaxj3bv	167	55	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	167	56	,	,	,
cord-001293-dfaxj3bv	167	57	macrophage	macrophage	NN
cord-001293-dfaxj3bv	167	58	recruitment	recruitment	NN
cord-001293-dfaxj3bv	167	59	,	,	,
cord-001293-dfaxj3bv	167	60	and	and	CC
cord-001293-dfaxj3bv	167	61	lung	lung	NN
cord-001293-dfaxj3bv	167	62	inflammation	inflammation	NN
cord-001293-dfaxj3bv	167	63	[	[	-LRB-
cord-001293-dfaxj3bv	167	64	84	84	CD
cord-001293-dfaxj3bv	167	65	]	]	-RRB-
cord-001293-dfaxj3bv	167	66	;	;	:
cord-001293-dfaxj3bv	167	67	and	and	CC
cord-001293-dfaxj3bv	167	68	,	,	,
cord-001293-dfaxj3bv	167	69	finally	finally	RB
cord-001293-dfaxj3bv	167	70	,	,	,
cord-001293-dfaxj3bv	167	71	increases	increase	VBZ
cord-001293-dfaxj3bv	167	72	production	production	NN
cord-001293-dfaxj3bv	167	73	of	of	IN
cord-001293-dfaxj3bv	167	74	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	167	75	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	167	76	by	by	IN
cord-001293-dfaxj3bv	167	77	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	167	78	and	and	CC
cord-001293-dfaxj3bv	167	79	T	t	NN
cord-001293-dfaxj3bv	167	80	cells	cell	NNS
cord-001293-dfaxj3bv	167	81	[	[	-LRB-
cord-001293-dfaxj3bv	167	82	85	85	CD
cord-001293-dfaxj3bv	167	83	]	]	-RRB-
cord-001293-dfaxj3bv	167	84	.	.	.
cord-001293-dfaxj3bv	168	1	Many	many	JJ
cord-001293-dfaxj3bv	168	2	other	other	JJ
cord-001293-dfaxj3bv	168	3	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	168	4	(	(	-LRB-
cord-001293-dfaxj3bv	168	5	for	for	IN
cord-001293-dfaxj3bv	168	6	example	example	NN
cord-001293-dfaxj3bv	168	7	,	,	,
cord-001293-dfaxj3bv	168	8	IL-2	IL-2	NNP
cord-001293-dfaxj3bv	168	9	,	,	,
cord-001293-dfaxj3bv	168	10	IL-12	IL-12	NNP
cord-001293-dfaxj3bv	168	11	,	,	,
cord-001293-dfaxj3bv	168	12	IL-15	IL-15	NNP
cord-001293-dfaxj3bv	168	13	,	,	,
cord-001293-dfaxj3bv	168	14	and	and	CC
cord-001293-dfaxj3bv	168	15	TNF	TNF	NNP
cord-001293-dfaxj3bv	168	16	)	)	-RRB-
cord-001293-dfaxj3bv	168	17	can	can	MD
cord-001293-dfaxj3bv	168	18	boost	boost	VB
cord-001293-dfaxj3bv	168	19	the	the	DT
cord-001293-dfaxj3bv	168	20	immune	immune	JJ
cord-001293-dfaxj3bv	168	21	system	system	NN
cord-001293-dfaxj3bv	168	22	and	and	CC
cord-001293-dfaxj3bv	168	23	are	be	VBP
cord-001293-dfaxj3bv	168	24	reported	report	VBN
cord-001293-dfaxj3bv	168	25	to	to	TO
cord-001293-dfaxj3bv	168	26	be	be	VB
cord-001293-dfaxj3bv	168	27	beneficial	beneficial	JJ
cord-001293-dfaxj3bv	168	28	in	in	IN
cord-001293-dfaxj3bv	168	29	murine	murine	JJ
cord-001293-dfaxj3bv	168	30	sepsis	sepsis	NN
cord-001293-dfaxj3bv	168	31	models	model	NNS
cord-001293-dfaxj3bv	168	32	.	.	.
cord-001293-dfaxj3bv	169	1	However	however	RB
cord-001293-dfaxj3bv	169	2	,	,	,
cord-001293-dfaxj3bv	169	3	one	one	NN
cord-001293-dfaxj3bv	169	4	wonders	wonder	NNS
cord-001293-dfaxj3bv	169	5	whether	whether	IN
cord-001293-dfaxj3bv	169	6	systemic	systemic	JJ
cord-001293-dfaxj3bv	169	7	treatment	treatment	NN
cord-001293-dfaxj3bv	169	8	with	with	IN
cord-001293-dfaxj3bv	169	9	any	any	DT
cord-001293-dfaxj3bv	169	10	immunostimulating	immunostimulate	VBG
cord-001293-dfaxj3bv	169	11	cytokine	cytokine	NN
cord-001293-dfaxj3bv	169	12	may	may	MD
cord-001293-dfaxj3bv	169	13	act	act	VB
cord-001293-dfaxj3bv	169	14	on	on	IN
cord-001293-dfaxj3bv	169	15	tissue	tissue	NN
cord-001293-dfaxj3bv	169	16	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	169	17	boosting	boost	VBG
cord-001293-dfaxj3bv	169	18	the	the	DT
cord-001293-dfaxj3bv	169	19	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	169	20	process	process	NN
cord-001293-dfaxj3bv	169	21	while	while	IN
cord-001293-dfaxj3bv	169	22	boosting	boost	VBG
cord-001293-dfaxj3bv	169	23	immune	immune	JJ
cord-001293-dfaxj3bv	169	24	status	status	NN
cord-001293-dfaxj3bv	169	25	as	as	RB
cord-001293-dfaxj3bv	169	26	well	well	RB
cord-001293-dfaxj3bv	169	27	.	.	.
cord-001293-dfaxj3bv	170	1	In	in	IN
cord-001293-dfaxj3bv	170	2	this	this	DT
cord-001293-dfaxj3bv	170	3	perspective	perspective	NN
cord-001293-dfaxj3bv	170	4	,	,	,
cord-001293-dfaxj3bv	170	5	the	the	DT
cord-001293-dfaxj3bv	170	6	attempt	attempt	NN
cord-001293-dfaxj3bv	170	7	to	to	TO
cord-001293-dfaxj3bv	170	8	treat	treat	VB
cord-001293-dfaxj3bv	170	9	peripheral	peripheral	JJ
cord-001293-dfaxj3bv	170	10	mononuclear	mononuclear	JJ
cord-001293-dfaxj3bv	170	11	cells	cell	NNS
cord-001293-dfaxj3bv	170	12	of	of	IN
cord-001293-dfaxj3bv	170	13	sepsis	sepsis	NN
cord-001293-dfaxj3bv	170	14	patients	patient	NNS
cord-001293-dfaxj3bv	170	15	ex	ex	IN
cord-001293-dfaxj3bv	170	16	vivo	vivo	FW
cord-001293-dfaxj3bv	170	17	with	with	IN
cord-001293-dfaxj3bv	170	18	IL-2	IL-2	NNP
cord-001293-dfaxj3bv	170	19	before	before	IN
cord-001293-dfaxj3bv	170	20	re	re	NN
cord-001293-dfaxj3bv	170	21	-	-	VBG
cord-001293-dfaxj3bv	170	22	injecting	inject	VBG
cord-001293-dfaxj3bv	170	23	them	-PRON-	PRP
cord-001293-dfaxj3bv	170	24	is	be	VBZ
cord-001293-dfaxj3bv	170	25	an	an	DT
cord-001293-dfaxj3bv	170	26	interesting	interesting	JJ
cord-001293-dfaxj3bv	170	27	approach	approach	NN
cord-001293-dfaxj3bv	170	28	that	that	WDT
cord-001293-dfaxj3bv	170	29	prevents	prevent	VBZ
cord-001293-dfaxj3bv	170	30	the	the	DT
cord-001293-dfaxj3bv	170	31	delivery	delivery	NN
cord-001293-dfaxj3bv	170	32	of	of	IN
cord-001293-dfaxj3bv	170	33	this	this	DT
cord-001293-dfaxj3bv	170	34	cytokine	cytokine	NN
cord-001293-dfaxj3bv	170	35	to	to	IN
cord-001293-dfaxj3bv	170	36	the	the	DT
cord-001293-dfaxj3bv	170	37	bloodstream	bloodstream	NN
cord-001293-dfaxj3bv	170	38	,	,	,
cord-001293-dfaxj3bv	170	39	allowing	allow	VBG
cord-001293-dfaxj3bv	170	40	it	-PRON-	PRP
cord-001293-dfaxj3bv	170	41	to	to	TO
cord-001293-dfaxj3bv	170	42	act	act	VB
cord-001293-dfaxj3bv	170	43	strictly	strictly	RB
cord-001293-dfaxj3bv	170	44	on	on	IN
cord-001293-dfaxj3bv	170	45	the	the	DT
cord-001293-dfaxj3bv	170	46	desired	desire	VBN
cord-001293-dfaxj3bv	170	47	cells	cell	NNS
cord-001293-dfaxj3bv	170	48	[	[	-LRB-
cord-001293-dfaxj3bv	170	49	86	86	CD
cord-001293-dfaxj3bv	170	50	]	]	-RRB-
cord-001293-dfaxj3bv	170	51	.	.	.
cord-001293-dfaxj3bv	171	1	In	in	IN
cord-001293-dfaxj3bv	171	2	this	this	DT
cord-001293-dfaxj3bv	171	3	study	study	NN
cord-001293-dfaxj3bv	171	4	,	,	,
cord-001293-dfaxj3bv	171	5	the	the	DT
cord-001293-dfaxj3bv	171	6	mortality	mortality	NN
cord-001293-dfaxj3bv	171	7	was	be	VBD
cord-001293-dfaxj3bv	171	8	8	8	CD
cord-001293-dfaxj3bv	171	9	%	%	NN
cord-001293-dfaxj3bv	171	10	in	in	IN
cord-001293-dfaxj3bv	171	11	the	the	DT
cord-001293-dfaxj3bv	171	12	extracorporeally	extracorporeally	RB
cord-001293-dfaxj3bv	171	13	treated	treat	VBN
cord-001293-dfaxj3bv	171	14	group	group	NN
cord-001293-dfaxj3bv	171	15	of	of	IN
cord-001293-dfaxj3bv	171	16	patients	patient	NNS
cord-001293-dfaxj3bv	171	17	(	(	-LRB-
cord-001293-dfaxj3bv	171	18	n	n	NN
cord-001293-dfaxj3bv	171	19	=	=	SYM
cord-001293-dfaxj3bv	171	20	121	121	CD
cord-001293-dfaxj3bv	171	21	)	)	-RRB-
cord-001293-dfaxj3bv	171	22	but	but	CC
cord-001293-dfaxj3bv	171	23	was	be	VBD
cord-001293-dfaxj3bv	171	24	21	21	CD
cord-001293-dfaxj3bv	171	25	%	%	NN
cord-001293-dfaxj3bv	171	26	in	in	IN
cord-001293-dfaxj3bv	171	27	the	the	DT
cord-001293-dfaxj3bv	171	28	patients	patient	NNS
cord-001293-dfaxj3bv	171	29	receiving	receive	VBG
cord-001293-dfaxj3bv	171	30	standard	standard	JJ
cord-001293-dfaxj3bv	171	31	treatment	treatment	NN
cord-001293-dfaxj3bv	171	32	(	(	-LRB-
cord-001293-dfaxj3bv	171	33	n	n	NN
cord-001293-dfaxj3bv	171	34	=	=	SYM
cord-001293-dfaxj3bv	171	35	52	52	CD
cord-001293-dfaxj3bv	171	36	)	)	-RRB-
cord-001293-dfaxj3bv	171	37	.	.	.
cord-001293-dfaxj3bv	172	1	Rather	rather	RB
cord-001293-dfaxj3bv	172	2	than	than	IN
cord-001293-dfaxj3bv	172	3	repeating	repeat	VBG
cord-001293-dfaxj3bv	172	4	the	the	DT
cord-001293-dfaxj3bv	172	5	mistakes	mistake	NNS
cord-001293-dfaxj3bv	172	6	of	of	IN
cord-001293-dfaxj3bv	172	7	past	past	JJ
cord-001293-dfaxj3bv	172	8	experimental	experimental	JJ
cord-001293-dfaxj3bv	172	9	treatments	treatment	NNS
cord-001293-dfaxj3bv	172	10	for	for	IN
cord-001293-dfaxj3bv	172	11	sepsis	sepsis	NN
cord-001293-dfaxj3bv	172	12	in	in	IN
cord-001293-dfaxj3bv	172	13	which	which	WDT
cord-001293-dfaxj3bv	172	14	therapies	therapy	NNS
cord-001293-dfaxj3bv	172	15	were	be	VBD
cord-001293-dfaxj3bv	172	16	developed	develop	VBN
cord-001293-dfaxj3bv	172	17	after	after	IN
cord-001293-dfaxj3bv	172	18	successful	successful	JJ
cord-001293-dfaxj3bv	172	19	preclinical	preclinical	JJ
cord-001293-dfaxj3bv	172	20	models	model	NNS
cord-001293-dfaxj3bv	172	21	that	that	WDT
cord-001293-dfaxj3bv	172	22	may	may	MD
cord-001293-dfaxj3bv	172	23	be	be	VB
cord-001293-dfaxj3bv	172	24	far	far	RB
cord-001293-dfaxj3bv	172	25	from	from	IN
cord-001293-dfaxj3bv	172	26	mimicking	mimic	VBG
cord-001293-dfaxj3bv	172	27	human	human	JJ
cord-001293-dfaxj3bv	172	28	disease	disease	NN
cord-001293-dfaxj3bv	172	29	,	,	,
cord-001293-dfaxj3bv	172	30	it	-PRON-	PRP
cord-001293-dfaxj3bv	172	31	would	would	MD
cord-001293-dfaxj3bv	172	32	be	be	VB
cord-001293-dfaxj3bv	172	33	ideal	ideal	JJ
cord-001293-dfaxj3bv	172	34	to	to	TO
cord-001293-dfaxj3bv	172	35	proceed	proceed	VB
cord-001293-dfaxj3bv	172	36	in	in	IN
cord-001293-dfaxj3bv	172	37	the	the	DT
cord-001293-dfaxj3bv	172	38	future	future	NN
cord-001293-dfaxj3bv	172	39	with	with	IN
cord-001293-dfaxj3bv	172	40	new	new	JJ
cord-001293-dfaxj3bv	172	41	treatments	treatment	NNS
cord-001293-dfaxj3bv	172	42	in	in	IN
cord-001293-dfaxj3bv	172	43	which	which	WDT
cord-001293-dfaxj3bv	172	44	extensive	extensive	JJ
cord-001293-dfaxj3bv	172	45	human	human	JJ
cord-001293-dfaxj3bv	172	46	data	datum	NNS
cord-001293-dfaxj3bv	172	47	are	be	VBP
cord-001293-dfaxj3bv	172	48	available	available	JJ
cord-001293-dfaxj3bv	172	49	prior	prior	RB
cord-001293-dfaxj3bv	172	50	to	to	IN
cord-001293-dfaxj3bv	172	51	embarking	embark	VBG
cord-001293-dfaxj3bv	172	52	on	on	IN
cord-001293-dfaxj3bv	172	53	expensive	expensive	JJ
cord-001293-dfaxj3bv	172	54	licensure	licensure	NN
cord-001293-dfaxj3bv	172	55	studies	study	NNS
cord-001293-dfaxj3bv	172	56	.	.	.
cord-001293-dfaxj3bv	173	1	Furthermore	furthermore	RB
cord-001293-dfaxj3bv	173	2	,	,	,
cord-001293-dfaxj3bv	173	3	identifying	identify	VBG
cord-001293-dfaxj3bv	173	4	currently	currently	RB
cord-001293-dfaxj3bv	173	5	licensed	license	VBN
cord-001293-dfaxj3bv	173	6	drugs	drug	NNS
cord-001293-dfaxj3bv	173	7	with	with	IN
cord-001293-dfaxj3bv	173	8	tolerable	tolerable	JJ
cord-001293-dfaxj3bv	173	9	safety	safety	NN
cord-001293-dfaxj3bv	173	10	profiles	profile	NNS
cord-001293-dfaxj3bv	173	11	as	as	IN
cord-001293-dfaxj3bv	173	12	potential	potential	JJ
cord-001293-dfaxj3bv	173	13	sepsis	sepsis	NN
cord-001293-dfaxj3bv	173	14	agents	agent	NNS
cord-001293-dfaxj3bv	173	15	leap	leap	NN
cord-001293-dfaxj3bv	173	16	-	-	HYPH
cord-001293-dfaxj3bv	173	17	frogs	frog	NNS
cord-001293-dfaxj3bv	173	18	costly	costly	JJ
cord-001293-dfaxj3bv	173	19	drug	drug	NN
cord-001293-dfaxj3bv	173	20	development	development	NN
cord-001293-dfaxj3bv	173	21	and	and	CC
cord-001293-dfaxj3bv	173	22	early	early	JJ
cord-001293-dfaxj3bv	173	23	-	-	HYPH
cord-001293-dfaxj3bv	173	24	phase	phase	NN
cord-001293-dfaxj3bv	173	25	human	human	JJ
cord-001293-dfaxj3bv	173	26	studies	study	NNS
cord-001293-dfaxj3bv	173	27	.	.	.
cord-001293-dfaxj3bv	174	1	In	in	IN
cord-001293-dfaxj3bv	174	2	animal	animal	NN
cord-001293-dfaxj3bv	174	3	models	model	NNS
cord-001293-dfaxj3bv	174	4	,	,	,
cord-001293-dfaxj3bv	174	5	extant	extant	JJ
cord-001293-dfaxj3bv	174	6	licensed	license	VBN
cord-001293-dfaxj3bv	174	7	drugs	drug	NNS
cord-001293-dfaxj3bv	174	8	,	,	,
cord-001293-dfaxj3bv	174	9	such	such	JJ
cord-001293-dfaxj3bv	174	10	as	as	IN
cord-001293-dfaxj3bv	174	11	chloroquine	chloroquine	NN
cord-001293-dfaxj3bv	174	12	[	[	-LRB-
cord-001293-dfaxj3bv	174	13	87	87	CD
cord-001293-dfaxj3bv	174	14	]	]	-RRB-
cord-001293-dfaxj3bv	174	15	and	and	CC
cord-001293-dfaxj3bv	174	16	androstenenediol	androstenenediol	NNP
cord-001293-dfaxj3bv	174	17	[	[	-LRB-
cord-001293-dfaxj3bv	174	18	51	51	CD
cord-001293-dfaxj3bv	174	19	]	]	-RRB-
cord-001293-dfaxj3bv	174	20	,	,	,
cord-001293-dfaxj3bv	174	21	have	have	VBP
cord-001293-dfaxj3bv	174	22	successfully	successfully	RB
cord-001293-dfaxj3bv	174	23	restored	restore	VBN
cord-001293-dfaxj3bv	174	24	immune	immune	JJ
cord-001293-dfaxj3bv	174	25	status	status	NN
cord-001293-dfaxj3bv	174	26	.	.	.
cord-001293-dfaxj3bv	175	1	Most	most	RBS
cord-001293-dfaxj3bv	175	2	interestingly	interestingly	RB
cord-001293-dfaxj3bv	175	3	,	,	,
cord-001293-dfaxj3bv	175	4	in	in	IN
cord-001293-dfaxj3bv	175	5	the	the	DT
cord-001293-dfaxj3bv	175	6	latter	latter	JJ
cord-001293-dfaxj3bv	175	7	case	case	NN
cord-001293-dfaxj3bv	175	8	,	,	,
cord-001293-dfaxj3bv	175	9	the	the	DT
cord-001293-dfaxj3bv	175	10	treatment	treatment	NN
cord-001293-dfaxj3bv	175	11	protected	protect	VBD
cord-001293-dfaxj3bv	175	12	mice	mouse	NNS
cord-001293-dfaxj3bv	175	13	against	against	IN
cord-001293-dfaxj3bv	175	14	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	175	15	sepsis	sepsis	NN
cord-001293-dfaxj3bv	175	16	and	and	CC
cord-001293-dfaxj3bv	175	17	boosted	boost	VBD
cord-001293-dfaxj3bv	175	18	altered	alter	VBN
cord-001293-dfaxj3bv	175	19	ex	ex	NN
cord-001293-dfaxj3bv	175	20	vivo	vivo	NN
cord-001293-dfaxj3bv	175	21	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	175	22	production	production	NN
cord-001293-dfaxj3bv	175	23	observed	observe	VBN
cord-001293-dfaxj3bv	175	24	with	with	IN
cord-001293-dfaxj3bv	175	25	peripheral	peripheral	JJ
cord-001293-dfaxj3bv	175	26	blood	blood	NN
cord-001293-dfaxj3bv	175	27	cells	cell	NNS
cord-001293-dfaxj3bv	175	28	and	and	CC
cord-001293-dfaxj3bv	175	29	spleen	spleen	NN
cord-001293-dfaxj3bv	175	30	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	175	31	,	,	,
cord-001293-dfaxj3bv	175	32	dampening	dampen	VBG
cord-001293-dfaxj3bv	175	33	production	production	NN
cord-001293-dfaxj3bv	175	34	observed	observe	VBN
cord-001293-dfaxj3bv	175	35	with	with	IN
cord-001293-dfaxj3bv	175	36	alveolar	alveolar	JJ
cord-001293-dfaxj3bv	175	37	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	175	38	and	and	CC
cord-001293-dfaxj3bv	175	39	Kupffer	Kupffer	NNP
cord-001293-dfaxj3bv	175	40	cells	cell	NNS
cord-001293-dfaxj3bv	175	41	.	.	.
cord-001293-dfaxj3bv	176	1	A	a	DT
cord-001293-dfaxj3bv	176	2	similar	similar	JJ
cord-001293-dfaxj3bv	176	3	compartmentalized	compartmentalize	VBN
cord-001293-dfaxj3bv	176	4	adapted	adapt	VBN
cord-001293-dfaxj3bv	176	5	specificity	specificity	NN
cord-001293-dfaxj3bv	176	6	was	be	VBD
cord-001293-dfaxj3bv	176	7	reported	report	VBN
cord-001293-dfaxj3bv	176	8	with	with	IN
cord-001293-dfaxj3bv	176	9	estradiol	estradiol	NN
cord-001293-dfaxj3bv	176	10	[	[	-LRB-
cord-001293-dfaxj3bv	176	11	88	88	CD
cord-001293-dfaxj3bv	176	12	]	]	-RRB-
cord-001293-dfaxj3bv	176	13	.	.	.
cord-001293-dfaxj3bv	177	1	Other	other	JJ
cord-001293-dfaxj3bv	177	2	approaches	approach	NNS
cord-001293-dfaxj3bv	177	3	involve	involve	VBP
cord-001293-dfaxj3bv	177	4	pro	pro	JJ
cord-001293-dfaxj3bv	177	5	-	-	JJ
cord-001293-dfaxj3bv	177	6	resolving	resolve	VBG
cord-001293-dfaxj3bv	177	7	lipid	lipid	NN
cord-001293-dfaxj3bv	177	8	mediators	mediator	NNS
cord-001293-dfaxj3bv	177	9	[	[	-LRB-
cord-001293-dfaxj3bv	177	10	89	89	CD
cord-001293-dfaxj3bv	177	11	]	]	-RRB-
cord-001293-dfaxj3bv	177	12	,	,	,
cord-001293-dfaxj3bv	177	13	although	although	IN
cord-001293-dfaxj3bv	177	14	it	-PRON-	PRP
cord-001293-dfaxj3bv	177	15	is	be	VBZ
cord-001293-dfaxj3bv	177	16	uncertain	uncertain	JJ
cord-001293-dfaxj3bv	177	17	whether	whether	IN
cord-001293-dfaxj3bv	177	18	they	-PRON-	PRP
cord-001293-dfaxj3bv	177	19	may	may	MD
cord-001293-dfaxj3bv	177	20	also	also	RB
cord-001293-dfaxj3bv	177	21	adversely	adversely	RB
cord-001293-dfaxj3bv	177	22	boost	boost	VB
cord-001293-dfaxj3bv	177	23	immune	immune	JJ
cord-001293-dfaxj3bv	177	24	status	status	NN
cord-001293-dfaxj3bv	177	25	.	.	.
cord-001293-dfaxj3bv	178	1	The	the	DT
cord-001293-dfaxj3bv	178	2	recently	recently	RB
cord-001293-dfaxj3bv	178	3	recognized	recognize	VBN
cord-001293-dfaxj3bv	178	4	aspirin	aspirin	NN
cord-001293-dfaxj3bv	178	5	-	-	HYPH
cord-001293-dfaxj3bv	178	6	triggered	trigger	VBN
cord-001293-dfaxj3bv	178	7	lipoxins	lipoxin	NNS
cord-001293-dfaxj3bv	178	8	,	,	,
cord-001293-dfaxj3bv	178	9	anti	anti	JJ
cord-001293-dfaxj3bv	178	10	-	-	JJ
cord-001293-dfaxj3bv	178	11	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	178	12	mediators	mediator	NNS
cord-001293-dfaxj3bv	178	13	of	of	IN
cord-001293-dfaxj3bv	178	14	inflammation	inflammation	NN
cord-001293-dfaxj3bv	178	15	resolution	resolution	NN
cord-001293-dfaxj3bv	178	16	,	,	,
cord-001293-dfaxj3bv	178	17	make	make	VB
cord-001293-dfaxj3bv	178	18	aspirin	aspirin	NN
cord-001293-dfaxj3bv	178	19	a	a	DT
cord-001293-dfaxj3bv	178	20	possible	possible	JJ
cord-001293-dfaxj3bv	178	21	inexpensive	inexpensive	JJ
cord-001293-dfaxj3bv	178	22	agent	agent	NN
cord-001293-dfaxj3bv	178	23	for	for	IN
cord-001293-dfaxj3bv	178	24	both	both	DT
cord-001293-dfaxj3bv	178	25	prevention	prevention	NN
cord-001293-dfaxj3bv	178	26	and	and	CC
cord-001293-dfaxj3bv	178	27	treatment	treatment	NN
cord-001293-dfaxj3bv	178	28	of	of	IN
cord-001293-dfaxj3bv	178	29	sepsis	sepsis	NN
cord-001293-dfaxj3bv	178	30	.	.	.
cord-001293-dfaxj3bv	179	1	Considerable	considerable	JJ
cord-001293-dfaxj3bv	179	2	observational	observational	JJ
cord-001293-dfaxj3bv	179	3	cohort	cohort	NN
cord-001293-dfaxj3bv	179	4	data	datum	NNS
cord-001293-dfaxj3bv	179	5	show	show	VBP
cord-001293-dfaxj3bv	179	6	improvements	improvement	NNS
cord-001293-dfaxj3bv	179	7	in	in	IN
cord-001293-dfaxj3bv	179	8	mortality	mortality	NN
cord-001293-dfaxj3bv	179	9	in	in	IN
cord-001293-dfaxj3bv	179	10	patients	patient	NNS
cord-001293-dfaxj3bv	179	11	with	with	IN
cord-001293-dfaxj3bv	179	12	sepsis	sepsis	NN
cord-001293-dfaxj3bv	179	13	pretreated	pretreate	VBN
cord-001293-dfaxj3bv	179	14	with	with	IN
cord-001293-dfaxj3bv	179	15	aspirin	aspirin	NN
cord-001293-dfaxj3bv	179	16	[	[	-LRB-
cord-001293-dfaxj3bv	179	17	90	90	CD
cord-001293-dfaxj3bv	179	18	]	]	-RRB-
cord-001293-dfaxj3bv	179	19	.	.	.
cord-001293-dfaxj3bv	180	1	This	this	DT
cord-001293-dfaxj3bv	180	2	approach	approach	NN
cord-001293-dfaxj3bv	180	3	is	be	VBZ
cord-001293-dfaxj3bv	180	4	being	be	VBG
cord-001293-dfaxj3bv	180	5	prospectively	prospectively	RB
cord-001293-dfaxj3bv	180	6	studied	study	VBN
cord-001293-dfaxj3bv	180	7	as	as	IN
cord-001293-dfaxj3bv	180	8	part	part	NN
cord-001293-dfaxj3bv	180	9	of	of	IN
cord-001293-dfaxj3bv	180	10	an	an	DT
cord-001293-dfaxj3bv	180	11	aspirin	aspirin	NN
cord-001293-dfaxj3bv	180	12	primary	primary	JJ
cord-001293-dfaxj3bv	180	13	prevention	prevention	NN
cord-001293-dfaxj3bv	180	14	trial	trial	NN
cord-001293-dfaxj3bv	180	15	.	.	.
cord-001293-dfaxj3bv	181	1	Could	Could	MD
cord-001293-dfaxj3bv	181	2	other	other	JJ
cord-001293-dfaxj3bv	181	3	immunomodulatory	immunomodulatory	JJ
cord-001293-dfaxj3bv	181	4	approaches	approach	NNS
cord-001293-dfaxj3bv	181	5	be	be	VB
cord-001293-dfaxj3bv	181	6	considered	consider	VBN
cord-001293-dfaxj3bv	181	7	with	with	IN
cord-001293-dfaxj3bv	181	8	less	less	JJR
cord-001293-dfaxj3bv	181	9	putative	putative	JJ
cord-001293-dfaxj3bv	181	10	dangerous	dangerous	JJ
cord-001293-dfaxj3bv	181	11	consequences	consequence	NNS
cord-001293-dfaxj3bv	181	12	on	on	IN
cord-001293-dfaxj3bv	181	13	inflamed	inflamed	JJ
cord-001293-dfaxj3bv	181	14	tissues	tissue	NNS
cord-001293-dfaxj3bv	181	15	.	.	.
cord-001293-dfaxj3bv	182	1	This	this	DT
cord-001293-dfaxj3bv	182	2	may	may	MD
cord-001293-dfaxj3bv	182	3	be	be	VB
cord-001293-dfaxj3bv	182	4	the	the	DT
cord-001293-dfaxj3bv	182	5	case	case	NN
cord-001293-dfaxj3bv	182	6	of	of	IN
cord-001293-dfaxj3bv	182	7	thymosin	thymosin	NN
cord-001293-dfaxj3bv	182	8	-	-	HYPH
cord-001293-dfaxj3bv	182	9	α1	α1	NN
cord-001293-dfaxj3bv	182	10	.	.	.
cord-001293-dfaxj3bv	183	1	Indeed	indeed	RB
cord-001293-dfaxj3bv	183	2	,	,	,
cord-001293-dfaxj3bv	183	3	a	a	DT
cord-001293-dfaxj3bv	183	4	very	very	RB
cord-001293-dfaxj3bv	183	5	promising	promising	JJ
cord-001293-dfaxj3bv	183	6	study	study	NN
cord-001293-dfaxj3bv	183	7	demonstrated	demonstrate	VBD
cord-001293-dfaxj3bv	183	8	its	-PRON-	PRP$
cord-001293-dfaxj3bv	183	9	efficiency	efficiency	NN
cord-001293-dfaxj3bv	183	10	to	to	TO
cord-001293-dfaxj3bv	183	11	improve	improve	VB
cord-001293-dfaxj3bv	183	12	clinical	clinical	JJ
cord-001293-dfaxj3bv	183	13	outcome	outcome	NN
cord-001293-dfaxj3bv	183	14	in	in	IN
cord-001293-dfaxj3bv	183	15	patients	patient	NNS
cord-001293-dfaxj3bv	183	16	with	with	IN
cord-001293-dfaxj3bv	183	17	severe	severe	JJ
cord-001293-dfaxj3bv	183	18	sepsis	sepsis	NN
cord-001293-dfaxj3bv	183	19	[	[	-LRB-
cord-001293-dfaxj3bv	183	20	91	91	CD
cord-001293-dfaxj3bv	183	21	]	]	-RRB-
cord-001293-dfaxj3bv	183	22	,	,	,
cord-001293-dfaxj3bv	183	23	after	after	IN
cord-001293-dfaxj3bv	183	24	a	a	DT
cord-001293-dfaxj3bv	183	25	preliminary	preliminary	JJ
cord-001293-dfaxj3bv	183	26	investigation	investigation	NN
cord-001293-dfaxj3bv	183	27	had	have	VBD
cord-001293-dfaxj3bv	183	28	demonstrated	demonstrate	VBN
cord-001293-dfaxj3bv	183	29	a	a	DT
cord-001293-dfaxj3bv	183	30	better	well	JJR
cord-001293-dfaxj3bv	183	31	performance	performance	NN
cord-001293-dfaxj3bv	183	32	with	with	IN
cord-001293-dfaxj3bv	183	33	respect	respect	NN
cord-001293-dfaxj3bv	183	34	to	to	IN
cord-001293-dfaxj3bv	183	35	organ	organ	NN
cord-001293-dfaxj3bv	183	36	failure	failure	NN
cord-001293-dfaxj3bv	183	37	scores	score	NNS
cord-001293-dfaxj3bv	183	38	in	in	IN
cord-001293-dfaxj3bv	183	39	thymosin	thymosin	NN
cord-001293-dfaxj3bv	183	40	-	-	HYPH
cord-001293-dfaxj3bv	183	41	α1-treated	α1-treate	VBN
cord-001293-dfaxj3bv	183	42	patients	patient	NNS
cord-001293-dfaxj3bv	183	43	with	with	IN
cord-001293-dfaxj3bv	183	44	sepsis	sepsis	NN
cord-001293-dfaxj3bv	183	45	arising	arise	VBG
cord-001293-dfaxj3bv	183	46	from	from	IN
cord-001293-dfaxj3bv	183	47	intra	intra	JJ
cord-001293-dfaxj3bv	183	48	-	-	JJ
cord-001293-dfaxj3bv	183	49	abdominal	abdominal	JJ
cord-001293-dfaxj3bv	183	50	infection	infection	NN
cord-001293-dfaxj3bv	183	51	due	due	IN
cord-001293-dfaxj3bv	183	52	to	to	IN
cord-001293-dfaxj3bv	183	53	carbapenem	carbapenem	JJ
cord-001293-dfaxj3bv	183	54	-	-	HYPH
cord-001293-dfaxj3bv	183	55	resistant	resistant	JJ
cord-001293-dfaxj3bv	183	56	bacteria	bacteria	NNS
cord-001293-dfaxj3bv	183	57	[	[	-LRB-
cord-001293-dfaxj3bv	183	58	92	92	CD
cord-001293-dfaxj3bv	183	59	]	]	-RRB-
cord-001293-dfaxj3bv	183	60	.	.	.
cord-001293-dfaxj3bv	184	1	However	however	RB
cord-001293-dfaxj3bv	184	2	,	,	,
cord-001293-dfaxj3bv	184	3	one	one	PRP
cord-001293-dfaxj3bv	184	4	must	must	MD
cord-001293-dfaxj3bv	184	5	call	call	VB
cord-001293-dfaxj3bv	184	6	for	for	IN
cord-001293-dfaxj3bv	184	7	caution	caution	NN
cord-001293-dfaxj3bv	184	8	since	since	IN
cord-001293-dfaxj3bv	184	9	thymosin	thymosin	NN
cord-001293-dfaxj3bv	184	10	-	-	HYPH
cord-001293-dfaxj3bv	184	11	α1	α1	NN
cord-001293-dfaxj3bv	184	12	can	can	MD
cord-001293-dfaxj3bv	184	13	also	also	RB
cord-001293-dfaxj3bv	184	14	favor	favor	VB
cord-001293-dfaxj3bv	184	15	the	the	DT
cord-001293-dfaxj3bv	184	16	production	production	NN
cord-001293-dfaxj3bv	184	17	of	of	IN
cord-001293-dfaxj3bv	184	18	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	184	19	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	184	20	and	and	CC
cord-001293-dfaxj3bv	184	21	nitric	nitric	NN
cord-001293-dfaxj3bv	184	22	oxide	oxide	NN
cord-001293-dfaxj3bv	184	23	and	and	CC
cord-001293-dfaxj3bv	184	24	further	further	JJ
cord-001293-dfaxj3bv	184	25	increases	increase	VBZ
cord-001293-dfaxj3bv	184	26	the	the	DT
cord-001293-dfaxj3bv	184	27	percentage	percentage	NN
cord-001293-dfaxj3bv	184	28	of	of	IN
cord-001293-dfaxj3bv	184	29	T	T	NNP
cord-001293-dfaxj3bv	184	30	reg	reg	NN
cord-001293-dfaxj3bv	184	31	cells	cell	NNS
cord-001293-dfaxj3bv	184	32	[	[	-LRB-
cord-001293-dfaxj3bv	184	33	93	93	CD
cord-001293-dfaxj3bv	184	34	,	,	,
cord-001293-dfaxj3bv	184	35	94	94	CD
cord-001293-dfaxj3bv	184	36	]	]	-RRB-
cord-001293-dfaxj3bv	184	37	.	.	.
cord-001293-dfaxj3bv	185	1	Still	still	RB
cord-001293-dfaxj3bv	185	2	,	,	,
cord-001293-dfaxj3bv	185	3	very	very	RB
cord-001293-dfaxj3bv	185	4	little	little	JJ
cord-001293-dfaxj3bv	185	5	is	be	VBZ
cord-001293-dfaxj3bv	185	6	known	know	VBN
cord-001293-dfaxj3bv	185	7	of	of	IN
cord-001293-dfaxj3bv	185	8	its	-PRON-	PRP$
cord-001293-dfaxj3bv	185	9	effect	effect	NN
cord-001293-dfaxj3bv	185	10	on	on	IN
cord-001293-dfaxj3bv	185	11	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	185	12	present	present	JJ
cord-001293-dfaxj3bv	185	13	in	in	IN
cord-001293-dfaxj3bv	185	14	different	different	JJ
cord-001293-dfaxj3bv	185	15	compartments	compartment	NNS
cord-001293-dfaxj3bv	185	16	.	.	.
cord-001293-dfaxj3bv	186	1	The	the	DT
cord-001293-dfaxj3bv	186	2	cell	cell	NN
cord-001293-dfaxj3bv	186	3	surface	surface	NN
cord-001293-dfaxj3bv	186	4	molecules	molecule	NNS
cord-001293-dfaxj3bv	186	5	containing	contain	VBG
cord-001293-dfaxj3bv	186	6	in	in	IN
cord-001293-dfaxj3bv	186	7	their	-PRON-	PRP$
cord-001293-dfaxj3bv	186	8	intracytoplasmic	intracytoplasmic	JJ
cord-001293-dfaxj3bv	186	9	domain	domain	NN
cord-001293-dfaxj3bv	186	10	an	an	DT
cord-001293-dfaxj3bv	186	11	immunoreceptor	immunoreceptor	JJ
cord-001293-dfaxj3bv	186	12	tyrosine	tyrosine	NN
cord-001293-dfaxj3bv	186	13	-	-	HYPH
cord-001293-dfaxj3bv	186	14	based	base	VBN
cord-001293-dfaxj3bv	186	15	inhibition	inhibition	NN
cord-001293-dfaxj3bv	186	16	motif	motif	NN
cord-001293-dfaxj3bv	186	17	-such	-such	:
cord-001293-dfaxj3bv	186	18	as	as	IN
cord-001293-dfaxj3bv	186	19	programmed	program	VBN
cord-001293-dfaxj3bv	186	20	death-1	death-1	NNP
cord-001293-dfaxj3bv	186	21	(	(	-LRB-
cord-001293-dfaxj3bv	186	22	PD-1	PD-1	NNP
cord-001293-dfaxj3bv	186	23	)	)	-RRB-
cord-001293-dfaxj3bv	186	24	,	,	,
cord-001293-dfaxj3bv	186	25	B	B	NNP
cord-001293-dfaxj3bv	186	26	and	and	CC
cord-001293-dfaxj3bv	186	27	T	t	NN
cord-001293-dfaxj3bv	186	28	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	186	29	attenuator	attenuator	NN
cord-001293-dfaxj3bv	186	30	(	(	-LRB-
cord-001293-dfaxj3bv	186	31	BTLA	BTLA	NNP
cord-001293-dfaxj3bv	186	32	)	)	-RRB-
cord-001293-dfaxj3bv	186	33	,	,	,
cord-001293-dfaxj3bv	186	34	and	and	CC
cord-001293-dfaxj3bv	186	35	cytotoxic	cytotoxic	JJ
cord-001293-dfaxj3bv	186	36	T	t	NN
cord-001293-dfaxj3bv	186	37	-	-	HYPH
cord-001293-dfaxj3bv	186	38	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	186	39	antigen	antigen	NN
cord-001293-dfaxj3bv	186	40	4	4	CD
cord-001293-dfaxj3bv	186	41	(	(	-LRB-
cord-001293-dfaxj3bv	186	42	CTLA-4	CTLA-4	NNP
cord-001293-dfaxj3bv	186	43	)	)	-RRB-
cord-001293-dfaxj3bv	187	1	-could	-could	:
cord-001293-dfaxj3bv	187	2	also	also	RB
cord-001293-dfaxj3bv	187	3	be	be	VB
cord-001293-dfaxj3bv	187	4	interesting	interesting	JJ
cord-001293-dfaxj3bv	187	5	targets	target	NNS
cord-001293-dfaxj3bv	187	6	for	for	IN
cord-001293-dfaxj3bv	187	7	new	new	JJ
cord-001293-dfaxj3bv	187	8	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	187	9	approaches	approach	NNS
cord-001293-dfaxj3bv	187	10	.	.	.
cord-001293-dfaxj3bv	188	1	The	the	DT
cord-001293-dfaxj3bv	188	2	expression	expression	NN
cord-001293-dfaxj3bv	188	3	of	of	IN
cord-001293-dfaxj3bv	188	4	PD-1	PD-1	NNP
cord-001293-dfaxj3bv	188	5	on	on	IN
cord-001293-dfaxj3bv	188	6	T	t	NN
cord-001293-dfaxj3bv	188	7	cells	cell	NNS
cord-001293-dfaxj3bv	188	8	and	and	CC
cord-001293-dfaxj3bv	188	9	its	-PRON-	PRP$
cord-001293-dfaxj3bv	188	10	ligand	ligand	NN
cord-001293-dfaxj3bv	188	11	(	(	-LRB-
cord-001293-dfaxj3bv	188	12	PD	PD	NNP
cord-001293-dfaxj3bv	188	13	-	-	HYPH
cord-001293-dfaxj3bv	188	14	L1	L1	NNP
cord-001293-dfaxj3bv	188	15	)	)	-RRB-
cord-001293-dfaxj3bv	188	16	on	on	IN
cord-001293-dfaxj3bv	188	17	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	188	18	is	be	VBZ
cord-001293-dfaxj3bv	188	19	upregulated	upregulate	VBN
cord-001293-dfaxj3bv	188	20	in	in	IN
cord-001293-dfaxj3bv	188	21	critically	critically	RB
cord-001293-dfaxj3bv	188	22	ill	ill	JJ
cord-001293-dfaxj3bv	188	23	[	[	-LRB-
cord-001293-dfaxj3bv	188	24	95	95	CD
cord-001293-dfaxj3bv	188	25	]	]	-RRB-
cord-001293-dfaxj3bv	188	26	or	or	CC
cord-001293-dfaxj3bv	188	27	septic	septic	JJ
cord-001293-dfaxj3bv	188	28	shock	shock	NN
cord-001293-dfaxj3bv	188	29	[	[	-LRB-
cord-001293-dfaxj3bv	188	30	96	96	CD
cord-001293-dfaxj3bv	188	31	]	]	-RRB-
cord-001293-dfaxj3bv	188	32	patients	patient	NNS
cord-001293-dfaxj3bv	188	33	.	.	.
cord-001293-dfaxj3bv	189	1	Increased	increase	VBN
cord-001293-dfaxj3bv	189	2	expressions	expression	NNS
cord-001293-dfaxj3bv	189	3	were	be	VBD
cord-001293-dfaxj3bv	189	4	associated	associate	VBN
cord-001293-dfaxj3bv	189	5	with	with	IN
cord-001293-dfaxj3bv	189	6	increased	increase	VBN
cord-001293-dfaxj3bv	189	7	occurrence	occurrence	NN
cord-001293-dfaxj3bv	189	8	of	of	IN
cord-001293-dfaxj3bv	189	9	secondary	secondary	JJ
cord-001293-dfaxj3bv	189	10	nosocomial	nosocomial	JJ
cord-001293-dfaxj3bv	189	11	infections	infection	NNS
cord-001293-dfaxj3bv	189	12	and	and	CC
cord-001293-dfaxj3bv	189	13	mortality	mortality	NN
cord-001293-dfaxj3bv	189	14	after	after	IN
cord-001293-dfaxj3bv	189	15	septic	septic	JJ
cord-001293-dfaxj3bv	189	16	shock	shock	NN
cord-001293-dfaxj3bv	189	17	[	[	-LRB-
cord-001293-dfaxj3bv	189	18	97	97	CD
cord-001293-dfaxj3bv	189	19	]	]	-RRB-
cord-001293-dfaxj3bv	189	20	.	.	.
cord-001293-dfaxj3bv	190	1	Not	not	RB
cord-001293-dfaxj3bv	190	2	only	only	RB
cord-001293-dfaxj3bv	190	3	are	be	VBP
cord-001293-dfaxj3bv	190	4	PD-1-deficient	pd-1-deficient	CD
cord-001293-dfaxj3bv	190	5	mice	mouse	NNS
cord-001293-dfaxj3bv	190	6	markedly	markedly	RB
cord-001293-dfaxj3bv	190	7	protected	protect	VBN
cord-001293-dfaxj3bv	190	8	from	from	IN
cord-001293-dfaxj3bv	190	9	the	the	DT
cord-001293-dfaxj3bv	190	10	lethality	lethality	NN
cord-001293-dfaxj3bv	190	11	of	of	IN
cord-001293-dfaxj3bv	190	12	sepsis	sepsis	NN
cord-001293-dfaxj3bv	190	13	,	,	,
cord-001293-dfaxj3bv	190	14	accompanied	accompany	VBN
cord-001293-dfaxj3bv	190	15	by	by	IN
cord-001293-dfaxj3bv	190	16	a	a	DT
cord-001293-dfaxj3bv	190	17	decreased	decrease	VBN
cord-001293-dfaxj3bv	190	18	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	190	19	burden	burden	NN
cord-001293-dfaxj3bv	190	20	and	and	CC
cord-001293-dfaxj3bv	190	21	suppressed	suppress	VBD
cord-001293-dfaxj3bv	190	22	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	190	23	cytokine	cytokine	NN
cord-001293-dfaxj3bv	190	24	response	response	NN
cord-001293-dfaxj3bv	190	25	[	[	-LRB-
cord-001293-dfaxj3bv	190	26	98	98	CD
cord-001293-dfaxj3bv	190	27	]	]	-RRB-
cord-001293-dfaxj3bv	190	28	,	,	,
cord-001293-dfaxj3bv	190	29	but	but	CC
cord-001293-dfaxj3bv	190	30	also	also	RB
cord-001293-dfaxj3bv	190	31	blockade	blockade	NN
cord-001293-dfaxj3bv	190	32	of	of	IN
cord-001293-dfaxj3bv	190	33	PD-1	PD-1	NNP
cord-001293-dfaxj3bv	190	34	or	or	CC
cord-001293-dfaxj3bv	190	35	PD	PD	NNP
cord-001293-dfaxj3bv	190	36	-	-	HYPH
cord-001293-dfaxj3bv	190	37	L1	L1	NNP
cord-001293-dfaxj3bv	190	38	improves	improve	VBZ
cord-001293-dfaxj3bv	190	39	survival	survival	NN
cord-001293-dfaxj3bv	190	40	in	in	IN
cord-001293-dfaxj3bv	190	41	a	a	DT
cord-001293-dfaxj3bv	190	42	murine	murine	JJ
cord-001293-dfaxj3bv	190	43	model	model	NN
cord-001293-dfaxj3bv	190	44	of	of	IN
cord-001293-dfaxj3bv	190	45	sepsis	sepsis	NN
cord-001293-dfaxj3bv	190	46	,	,	,
cord-001293-dfaxj3bv	190	47	reverses	reverse	VBZ
cord-001293-dfaxj3bv	190	48	immune	immune	JJ
cord-001293-dfaxj3bv	190	49	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	190	50	,	,	,
cord-001293-dfaxj3bv	190	51	inhibits	inhibit	VBZ
cord-001293-dfaxj3bv	190	52	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	190	53	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	190	54	,	,	,
cord-001293-dfaxj3bv	190	55	and	and	CC
cord-001293-dfaxj3bv	190	56	attenuates	attenuate	VBZ
cord-001293-dfaxj3bv	190	57	organ	organ	NN
cord-001293-dfaxj3bv	190	58	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	190	59	[	[	-LRB-
cord-001293-dfaxj3bv	190	60	99	99	CD
cord-001293-dfaxj3bv	190	61	]	]	-RRB-
cord-001293-dfaxj3bv	190	62	[	[	-LRB-
cord-001293-dfaxj3bv	190	63	100	100	CD
cord-001293-dfaxj3bv	190	64	]	]	-RRB-
cord-001293-dfaxj3bv	190	65	[	[	-LRB-
cord-001293-dfaxj3bv	190	66	101	101	CD
cord-001293-dfaxj3bv	190	67	]	]	-RRB-
cord-001293-dfaxj3bv	190	68	.	.	.
cord-001293-dfaxj3bv	191	1	The	the	DT
cord-001293-dfaxj3bv	191	2	relevance	relevance	NN
cord-001293-dfaxj3bv	191	3	of	of	IN
cord-001293-dfaxj3bv	191	4	these	these	DT
cord-001293-dfaxj3bv	191	5	observations	observation	NNS
cord-001293-dfaxj3bv	191	6	in	in	IN
cord-001293-dfaxj3bv	191	7	human	human	JJ
cord-001293-dfaxj3bv	191	8	settings	setting	NNS
cord-001293-dfaxj3bv	191	9	is	be	VBZ
cord-001293-dfaxj3bv	191	10	still	still	RB
cord-001293-dfaxj3bv	191	11	needed	need	VBN
cord-001293-dfaxj3bv	191	12	.	.	.
cord-001293-dfaxj3bv	192	1	CTLA-4	CTLA-4	NNP
cord-001293-dfaxj3bv	192	2	is	be	VBZ
cord-001293-dfaxj3bv	192	3	a	a	DT
cord-001293-dfaxj3bv	192	4	high	high	JJ
cord-001293-dfaxj3bv	192	5	-	-	HYPH
cord-001293-dfaxj3bv	192	6	avidity	avidity	NN
cord-001293-dfaxj3bv	192	7	receptor	receptor	NN
cord-001293-dfaxj3bv	192	8	for	for	IN
cord-001293-dfaxj3bv	192	9	CD80	CD80	NNP
cord-001293-dfaxj3bv	192	10	and	and	CC
cord-001293-dfaxj3bv	192	11	CD86	CD86	NNP
cord-001293-dfaxj3bv	192	12	.	.	.
cord-001293-dfaxj3bv	193	1	Enhanced	enhanced	JJ
cord-001293-dfaxj3bv	193	2	CTLA-4	CTLA-4	NNP
cord-001293-dfaxj3bv	193	3	expression	expression	NN
cord-001293-dfaxj3bv	193	4	was	be	VBD
cord-001293-dfaxj3bv	193	5	demonstrated	demonstrate	VBN
cord-001293-dfaxj3bv	193	6	more	more	RBR
cord-001293-dfaxj3bv	193	7	frequently	frequently	RB
cord-001293-dfaxj3bv	193	8	in	in	IN
cord-001293-dfaxj3bv	193	9	patients	patient	NNS
cord-001293-dfaxj3bv	193	10	with	with	IN
cord-001293-dfaxj3bv	193	11	sepsis	sepsis	NN
cord-001293-dfaxj3bv	193	12	than	than	IN
cord-001293-dfaxj3bv	193	13	in	in	IN
cord-001293-dfaxj3bv	193	14	non	non	JJ
cord-001293-dfaxj3bv	193	15	-	-	JJ
cord-001293-dfaxj3bv	193	16	infected	infected	JJ
cord-001293-dfaxj3bv	193	17	critically	critically	RB
cord-001293-dfaxj3bv	193	18	ill	ill	JJ
cord-001293-dfaxj3bv	193	19	patients	patient	NNS
cord-001293-dfaxj3bv	193	20	or	or	CC
cord-001293-dfaxj3bv	193	21	control	control	NN
cord-001293-dfaxj3bv	193	22	subjects	subject	NNS
cord-001293-dfaxj3bv	193	23	[	[	-LRB-
cord-001293-dfaxj3bv	193	24	102	102	CD
cord-001293-dfaxj3bv	193	25	]	]	-RRB-
cord-001293-dfaxj3bv	193	26	,	,	,
cord-001293-dfaxj3bv	193	27	and	and	CC
cord-001293-dfaxj3bv	193	28	blocking	block	VBG
cord-001293-dfaxj3bv	193	29	CTLA-4	CTLA-4	NNPS
cord-001293-dfaxj3bv	193	30	improved	improve	VBD
cord-001293-dfaxj3bv	193	31	survival	survival	NN
cord-001293-dfaxj3bv	193	32	in	in	IN
cord-001293-dfaxj3bv	193	33	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	193	34	and	and	CC
cord-001293-dfaxj3bv	193	35	fungal	fungal	JJ
cord-001293-dfaxj3bv	193	36	experimental	experimental	JJ
cord-001293-dfaxj3bv	193	37	sepsis	sepsis	NN
cord-001293-dfaxj3bv	193	38	[	[	-LRB-
cord-001293-dfaxj3bv	193	39	103	103	CD
cord-001293-dfaxj3bv	193	40	,	,	,
cord-001293-dfaxj3bv	193	41	104	104	CD
cord-001293-dfaxj3bv	193	42	]	]	-RRB-
cord-001293-dfaxj3bv	193	43	.	.	.
cord-001293-dfaxj3bv	194	1	However	however	RB
cord-001293-dfaxj3bv	194	2	,	,	,
cord-001293-dfaxj3bv	194	3	the	the	DT
cord-001293-dfaxj3bv	194	4	use	use	NN
cord-001293-dfaxj3bv	194	5	of	of	IN
cord-001293-dfaxj3bv	194	6	such	such	PDT
cord-001293-dfaxj3bv	194	7	an	an	DT
cord-001293-dfaxj3bv	194	8	approach	approach	NN
cord-001293-dfaxj3bv	194	9	seems	seem	VBZ
cord-001293-dfaxj3bv	194	10	tricky	tricky	JJ
cord-001293-dfaxj3bv	194	11	since	since	IN
cord-001293-dfaxj3bv	194	12	,	,	,
cord-001293-dfaxj3bv	194	13	in	in	IN
cord-001293-dfaxj3bv	194	14	animal	animal	NN
cord-001293-dfaxj3bv	194	15	models	model	NNS
cord-001293-dfaxj3bv	194	16	at	at	IN
cord-001293-dfaxj3bv	194	17	high	high	JJ
cord-001293-dfaxj3bv	194	18	dose	dose	NN
cord-001293-dfaxj3bv	194	19	,	,	,
cord-001293-dfaxj3bv	194	20	anti	anti	NNS
cord-001293-dfaxj3bv	194	21	-	-	NNS
cord-001293-dfaxj3bv	194	22	CTLA-4	CTLA-4	NNS
cord-001293-dfaxj3bv	194	23	could	could	MD
cord-001293-dfaxj3bv	194	24	worsen	worsen	VB
cord-001293-dfaxj3bv	194	25	survival	survival	NN
cord-001293-dfaxj3bv	194	26	[	[	-LRB-
cord-001293-dfaxj3bv	194	27	103	103	CD
cord-001293-dfaxj3bv	194	28	]	]	-RRB-
cord-001293-dfaxj3bv	194	29	,	,	,
cord-001293-dfaxj3bv	194	30	and	and	CC
cord-001293-dfaxj3bv	194	31	the	the	DT
cord-001293-dfaxj3bv	194	32	use	use	NN
cord-001293-dfaxj3bv	194	33	of	of	IN
cord-001293-dfaxj3bv	194	34	Abatacept	Abatacept	NNP
cord-001293-dfaxj3bv	194	35	(	(	-LRB-
cord-001293-dfaxj3bv	194	36	a	a	DT
cord-001293-dfaxj3bv	194	37	soluble	soluble	JJ
cord-001293-dfaxj3bv	194	38	CTLA-4	CTLA-4	NNS
cord-001293-dfaxj3bv	194	39	dimerized	dimerize	VBD
cord-001293-dfaxj3bv	194	40	with	with	IN
cord-001293-dfaxj3bv	194	41	an	an	DT
cord-001293-dfaxj3bv	194	42	Fc	Fc	NNP
cord-001293-dfaxj3bv	194	43	fragment	fragment	NN
cord-001293-dfaxj3bv	194	44	of	of	IN
cord-001293-dfaxj3bv	194	45	immunoglobulin	immunoglobulin	NN
cord-001293-dfaxj3bv	194	46	)	)	-RRB-
cord-001293-dfaxj3bv	194	47	led	lead	VBD
cord-001293-dfaxj3bv	194	48	to	to	IN
cord-001293-dfaxj3bv	194	49	increased	increase	VBN
cord-001293-dfaxj3bv	194	50	survival	survival	NN
cord-001293-dfaxj3bv	194	51	in	in	IN
cord-001293-dfaxj3bv	194	52	invasive	invasive	JJ
cord-001293-dfaxj3bv	194	53	pneumococcal	pneumococcal	JJ
cord-001293-dfaxj3bv	194	54	infection	infection	NN
cord-001293-dfaxj3bv	194	55	[	[	-LRB-
cord-001293-dfaxj3bv	194	56	105	105	CD
cord-001293-dfaxj3bv	194	57	]	]	-RRB-
cord-001293-dfaxj3bv	194	58	.	.	.
cord-001293-dfaxj3bv	195	1	Similarly	similarly	RB
cord-001293-dfaxj3bv	195	2	,	,	,
cord-001293-dfaxj3bv	195	3	BTLA	BTLA	NNP
cord-001293-dfaxj3bv	195	4	expression	expression	NN
cord-001293-dfaxj3bv	195	5	is	be	VBZ
cord-001293-dfaxj3bv	195	6	enhanced	enhance	VBN
cord-001293-dfaxj3bv	195	7	in	in	IN
cord-001293-dfaxj3bv	195	8	patients	patient	NNS
cord-001293-dfaxj3bv	195	9	with	with	IN
cord-001293-dfaxj3bv	195	10	SIRS	SIRS	NNP
cord-001293-dfaxj3bv	195	11	or	or	CC
cord-001293-dfaxj3bv	195	12	sepsis	sepsis	NN
cord-001293-dfaxj3bv	195	13	[	[	-LRB-
cord-001293-dfaxj3bv	195	14	106	106	CD
cord-001293-dfaxj3bv	195	15	]	]	-RRB-
cord-001293-dfaxj3bv	195	16	and	and	CC
cord-001293-dfaxj3bv	195	17	,	,	,
cord-001293-dfaxj3bv	195	18	in	in	IN
cord-001293-dfaxj3bv	195	19	a	a	DT
cord-001293-dfaxj3bv	195	20	murine	murine	JJ
cord-001293-dfaxj3bv	195	21	model	model	NN
cord-001293-dfaxj3bv	195	22	of	of	IN
cord-001293-dfaxj3bv	195	23	sepsis	sepsis	NN
cord-001293-dfaxj3bv	195	24	,	,	,
cord-001293-dfaxj3bv	195	25	BTLA	BTLA	NNP
cord-001293-dfaxj3bv	195	26	-	-	HYPH
cord-001293-dfaxj3bv	195	27	deficient	deficient	JJ
cord-001293-dfaxj3bv	195	28	mice	mouse	NNS
cord-001293-dfaxj3bv	195	29	displayed	display	VBD
cord-001293-dfaxj3bv	195	30	an	an	DT
cord-001293-dfaxj3bv	195	31	enhanced	enhance	VBN
cord-001293-dfaxj3bv	195	32	resistance	resistance	NN
cord-001293-dfaxj3bv	195	33	[	[	-LRB-
cord-001293-dfaxj3bv	195	34	107	107	CD
cord-001293-dfaxj3bv	195	35	]	]	-RRB-
cord-001293-dfaxj3bv	195	36	.	.	.
cord-001293-dfaxj3bv	196	1	In	in	IN
cord-001293-dfaxj3bv	196	2	contrast	contrast	NN
cord-001293-dfaxj3bv	196	3	,	,	,
cord-001293-dfaxj3bv	196	4	these	these	DT
cord-001293-dfaxj3bv	196	5	mice	mouse	NNS
cord-001293-dfaxj3bv	196	6	displayed	display	VBD
cord-001293-dfaxj3bv	196	7	enhanced	enhanced	JJ
cord-001293-dfaxj3bv	196	8	susceptibility	susceptibility	NN
cord-001293-dfaxj3bv	196	9	to	to	IN
cord-001293-dfaxj3bv	196	10	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	196	11	-	-	HYPH
cord-001293-dfaxj3bv	196	12	induced	induce	VBN
cord-001293-dfaxj3bv	196	13	shock	shock	NN
cord-001293-dfaxj3bv	196	14	[	[	-LRB-
cord-001293-dfaxj3bv	196	15	108	108	CD
cord-001293-dfaxj3bv	196	16	]	]	-RRB-
cord-001293-dfaxj3bv	196	17	.	.	.
cord-001293-dfaxj3bv	197	1	Accordingly	accordingly	RB
cord-001293-dfaxj3bv	197	2	,	,	,
cord-001293-dfaxj3bv	197	3	the	the	DT
cord-001293-dfaxj3bv	197	4	exact	exact	JJ
cord-001293-dfaxj3bv	197	5	role	role	NN
cord-001293-dfaxj3bv	197	6	of	of	IN
cord-001293-dfaxj3bv	197	7	BTLA	BTLA	NNP
cord-001293-dfaxj3bv	197	8	needs	need	VBZ
cord-001293-dfaxj3bv	197	9	to	to	TO
cord-001293-dfaxj3bv	197	10	be	be	VB
cord-001293-dfaxj3bv	197	11	further	further	RB
cord-001293-dfaxj3bv	197	12	deciphered	decipher	VBN
cord-001293-dfaxj3bv	197	13	before	before	IN
cord-001293-dfaxj3bv	197	14	strategies	strategy	NNS
cord-001293-dfaxj3bv	197	15	targeting	target	VBG
cord-001293-dfaxj3bv	197	16	BTLA	BTLA	NNP
cord-001293-dfaxj3bv	197	17	could	could	MD
cord-001293-dfaxj3bv	197	18	be	be	VB
cord-001293-dfaxj3bv	197	19	proposed	propose	VBN
cord-001293-dfaxj3bv	197	20	to	to	TO
cord-001293-dfaxj3bv	197	21	treat	treat	VB
cord-001293-dfaxj3bv	197	22	patients	patient	NNS
cord-001293-dfaxj3bv	197	23	with	with	IN
cord-001293-dfaxj3bv	197	24	sepsis	sepsis	NN
cord-001293-dfaxj3bv	197	25	.	.	.
cord-001293-dfaxj3bv	198	1	New	new	JJ
cord-001293-dfaxj3bv	198	2	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	198	3	approaches	approach	NNS
cord-001293-dfaxj3bv	198	4	to	to	TO
cord-001293-dfaxj3bv	198	5	treat	treat	VB
cord-001293-dfaxj3bv	198	6	sepsis	sepsis	NN
cord-001293-dfaxj3bv	198	7	should	should	MD
cord-001293-dfaxj3bv	198	8	take	take	VB
cord-001293-dfaxj3bv	198	9	into	into	IN
cord-001293-dfaxj3bv	198	10	consideration	consideration	NN
cord-001293-dfaxj3bv	198	11	that	that	IN
cord-001293-dfaxj3bv	198	12	the	the	DT
cord-001293-dfaxj3bv	198	13	immune	immune	JJ
cord-001293-dfaxj3bv	198	14	status	status	NN
cord-001293-dfaxj3bv	198	15	of	of	IN
cord-001293-dfaxj3bv	198	16	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	198	17	in	in	IN
cord-001293-dfaxj3bv	198	18	the	the	DT
cord-001293-dfaxj3bv	198	19	peripheral	peripheral	JJ
cord-001293-dfaxj3bv	198	20	blood	blood	NN
cord-001293-dfaxj3bv	198	21	might	may	MD
cord-001293-dfaxj3bv	198	22	be	be	VB
cord-001293-dfaxj3bv	198	23	quite	quite	RB
cord-001293-dfaxj3bv	198	24	different	different	JJ
cord-001293-dfaxj3bv	198	25	from	from	IN
cord-001293-dfaxj3bv	198	26	those	those	DT
cord-001293-dfaxj3bv	198	27	present	present	JJ
cord-001293-dfaxj3bv	198	28	in	in	IN
cord-001293-dfaxj3bv	198	29	inflamed	inflamed	JJ
cord-001293-dfaxj3bv	198	30	tissues	tissue	NNS
cord-001293-dfaxj3bv	198	31	.	.	.
cord-001293-dfaxj3bv	199	1	We	-PRON-	PRP
cord-001293-dfaxj3bv	199	2	believe	believe	VBP
cord-001293-dfaxj3bv	199	3	that	that	IN
cord-001293-dfaxj3bv	199	4	a	a	DT
cord-001293-dfaxj3bv	199	5	systemic	systemic	JJ
cord-001293-dfaxj3bv	199	6	approach	approach	NN
cord-001293-dfaxj3bv	199	7	to	to	IN
cord-001293-dfaxj3bv	199	8	immune	immune	JJ
cord-001293-dfaxj3bv	199	9	stimulation	stimulation	NN
cord-001293-dfaxj3bv	199	10	is	be	VBZ
cord-001293-dfaxj3bv	199	11	not	not	RB
cord-001293-dfaxj3bv	199	12	appropriate	appropriate	JJ
cord-001293-dfaxj3bv	199	13	if	if	IN
cord-001293-dfaxj3bv	199	14	immune	immune	JJ
cord-001293-dfaxj3bv	199	15	cells	cell	NNS
cord-001293-dfaxj3bv	199	16	are	be	VBP
cord-001293-dfaxj3bv	199	17	boosted	boost	VBN
cord-001293-dfaxj3bv	199	18	generally	generally	RB
cord-001293-dfaxj3bv	199	19	,	,	,
cord-001293-dfaxj3bv	199	20	independent	independent	JJ
cord-001293-dfaxj3bv	199	21	of	of	IN
cord-001293-dfaxj3bv	199	22	their	-PRON-	PRP$
cord-001293-dfaxj3bv	199	23	location	location	NN
cord-001293-dfaxj3bv	199	24	.	.	.
cord-001293-dfaxj3bv	200	1	An	an	DT
cord-001293-dfaxj3bv	200	2	ideal	ideal	JJ
cord-001293-dfaxj3bv	200	3	drug	drug	NN
cord-001293-dfaxj3bv	200	4	would	would	MD
cord-001293-dfaxj3bv	200	5	limit	limit	VB
cord-001293-dfaxj3bv	200	6	the	the	DT
cord-001293-dfaxj3bv	200	7	overzealous	overzealous	JJ
cord-001293-dfaxj3bv	200	8	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	200	9	process	process	NN
cord-001293-dfaxj3bv	200	10	that	that	WDT
cord-001293-dfaxj3bv	200	11	leads	lead	VBZ
cord-001293-dfaxj3bv	200	12	to	to	IN
cord-001293-dfaxj3bv	200	13	organ	organ	NN
cord-001293-dfaxj3bv	200	14	failure	failure	NN
cord-001293-dfaxj3bv	200	15	and	and	CC
cord-001293-dfaxj3bv	200	16	favor	favor	VB
cord-001293-dfaxj3bv	200	17	homeostatic	homeostatic	JJ
cord-001293-dfaxj3bv	200	18	responsiveness	responsiveness	NN
cord-001293-dfaxj3bv	200	19	of	of	IN
cord-001293-dfaxj3bv	200	20	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	200	21	(	(	-LRB-
cord-001293-dfaxj3bv	200	22	Figure	figure	NN
cord-001293-dfaxj3bv	200	23	2	2	CD
cord-001293-dfaxj3bv	200	24	)	)	-RRB-
cord-001293-dfaxj3bv	200	25	.	.	.
cord-001293-dfaxj3bv	201	1	This	this	DT
cord-001293-dfaxj3bv	201	2	is	be	VBZ
cord-001293-dfaxj3bv	201	3	the	the	DT
cord-001293-dfaxj3bv	201	4	challenge	challenge	NN
cord-001293-dfaxj3bv	201	5	we	-PRON-	PRP
cord-001293-dfaxj3bv	201	6	have	have	VBP
cord-001293-dfaxj3bv	201	7	to	to	TO
cord-001293-dfaxj3bv	201	8	address	address	VB
cord-001293-dfaxj3bv	201	9	if	if	IN
cord-001293-dfaxj3bv	201	10	we	-PRON-	PRP
cord-001293-dfaxj3bv	201	11	wish	wish	VBP
cord-001293-dfaxj3bv	201	12	to	to	TO
cord-001293-dfaxj3bv	201	13	avoid	avoid	VB
cord-001293-dfaxj3bv	201	14	further	further	JJ
cord-001293-dfaxj3bv	201	15	decades	decade	NNS
cord-001293-dfaxj3bv	201	16	of	of	IN
cord-001293-dfaxj3bv	201	17	disillusionment	disillusionment	NN
cord-001293-dfaxj3bv	201	18	.	.	.
cord-001293-dfaxj3bv	202	1	Figure	figure	NN
cord-001293-dfaxj3bv	202	2	2	2	CD
cord-001293-dfaxj3bv	202	3	New	new	JJ
cord-001293-dfaxj3bv	202	4	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	202	5	interventions	intervention	NNS
cord-001293-dfaxj3bv	202	6	should	should	MD
cord-001293-dfaxj3bv	202	7	address	address	VB
cord-001293-dfaxj3bv	202	8	both	both	CC
cord-001293-dfaxj3bv	202	9	the	the	DT
cord-001293-dfaxj3bv	202	10	events	event	NNS
cord-001293-dfaxj3bv	202	11	in	in	IN
cord-001293-dfaxj3bv	202	12	the	the	DT
cord-001293-dfaxj3bv	202	13	tissues	tissue	NNS
cord-001293-dfaxj3bv	202	14	that	that	WDT
cord-001293-dfaxj3bv	202	15	lead	lead	VBP
cord-001293-dfaxj3bv	202	16	to	to	IN
cord-001293-dfaxj3bv	202	17	organ	organ	NN
cord-001293-dfaxj3bv	202	18	failure	failure	NN
cord-001293-dfaxj3bv	202	19	and	and	CC
cord-001293-dfaxj3bv	202	20	the	the	DT
cord-001293-dfaxj3bv	202	21	altered	alter	VBN
cord-001293-dfaxj3bv	202	22	immune	immune	JJ
cord-001293-dfaxj3bv	202	23	status	status	NN
cord-001293-dfaxj3bv	202	24	of	of	IN
cord-001293-dfaxj3bv	202	25	leukocytes	leukocyte	NNS
cord-001293-dfaxj3bv	202	26	restricted	restrict	VBN
cord-001293-dfaxj3bv	202	27	to	to	IN
cord-001293-dfaxj3bv	202	28	some	some	DT
cord-001293-dfaxj3bv	202	29	specific	specific	JJ
cord-001293-dfaxj3bv	202	30	compartments	compartment	NNS
cord-001293-dfaxj3bv	202	31	.	.	.
cord-001293-dfaxj3bv	203	1	CARS	car	NNS
cord-001293-dfaxj3bv	203	2	:	:	:
cord-001293-dfaxj3bv	204	1	Compensatory	compensatory	JJ
cord-001293-dfaxj3bv	204	2	anti	anti	JJ
cord-001293-dfaxj3bv	204	3	-	-	JJ
cord-001293-dfaxj3bv	204	4	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	204	5	response	response	NN
cord-001293-dfaxj3bv	204	6	syndrome	syndrome	NN
cord-001293-dfaxj3bv	204	7	;	;	:
cord-001293-dfaxj3bv	204	8	CMV	CMV	NNP
cord-001293-dfaxj3bv	204	9	:	:	:
cord-001293-dfaxj3bv	204	10	Cytomegalovirus	Cytomegalovirus	NNP
cord-001293-dfaxj3bv	204	11	;	;	:
cord-001293-dfaxj3bv	204	12	CTLA-4	CTLA-4	NNS
cord-001293-dfaxj3bv	204	13	:	:	:
cord-001293-dfaxj3bv	205	1	Cytotoxic	Cytotoxic	NNP
cord-001293-dfaxj3bv	205	2	T	t	NN
cord-001293-dfaxj3bv	205	3	-	-	HYPH
cord-001293-dfaxj3bv	205	4	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	205	5	antigen	antigen	NN
cord-001293-dfaxj3bv	205	6	4	4	CD
cord-001293-dfaxj3bv	205	7	;	;	:
cord-001293-dfaxj3bv	205	8	DC	DC	NNP
cord-001293-dfaxj3bv	205	9	:	:	:
cord-001293-dfaxj3bv	205	10	Dendritic	dendritic	JJ
cord-001293-dfaxj3bv	205	11	cell	cell	NN
cord-001293-dfaxj3bv	205	12	;	;	:
cord-001293-dfaxj3bv	205	13	GM	GM	NNP
cord-001293-dfaxj3bv	205	14	-	-	HYPH
cord-001293-dfaxj3bv	205	15	CSF	CSF	NNP
cord-001293-dfaxj3bv	205	16	:	:	:
cord-001293-dfaxj3bv	205	17	Granulocyte	Granulocyte	NNP
cord-001293-dfaxj3bv	205	18	-	-	HYPH
cord-001293-dfaxj3bv	205	19	macrophage	macrophage	NN
cord-001293-dfaxj3bv	205	20	colony	colony	NN
cord-001293-dfaxj3bv	205	21	-	-	HYPH
cord-001293-dfaxj3bv	205	22	stimulating	stimulate	VBG
cord-001293-dfaxj3bv	205	23	factor	factor	NN
cord-001293-dfaxj3bv	205	24	;	;	:
cord-001293-dfaxj3bv	205	25	HKSA	HKSA	NNP
cord-001293-dfaxj3bv	205	26	:	:	:
cord-001293-dfaxj3bv	206	1	Heat	heat	NN
cord-001293-dfaxj3bv	206	2	-	-	HYPH
cord-001293-dfaxj3bv	206	3	killed	kill	VBN
cord-001293-dfaxj3bv	206	4	Staphylococcus	Staphylococcus	NNP
cord-001293-dfaxj3bv	206	5	aureus	aureus	NN
cord-001293-dfaxj3bv	207	1	HSV	HSV	NNP
cord-001293-dfaxj3bv	207	2	:	:	:
cord-001293-dfaxj3bv	207	3	Herpes	Herpes	NNP
cord-001293-dfaxj3bv	207	4	simplex	simplex	NN
cord-001293-dfaxj3bv	207	5	virus	virus	NN
cord-001293-dfaxj3bv	207	6	;	;	:
cord-001293-dfaxj3bv	207	7	IFNγ	IFNγ	NNS
cord-001293-dfaxj3bv	207	8	:	:	:
cord-001293-dfaxj3bv	207	9	Interferon	interferon	NN
cord-001293-dfaxj3bv	207	10	-	-	HYPH
cord-001293-dfaxj3bv	207	11	gamma	gamma	NN
cord-001293-dfaxj3bv	207	12	LPS	lp	NNS
cord-001293-dfaxj3bv	207	13	:	:	:
cord-001293-dfaxj3bv	207	14	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-001293-dfaxj3bv	207	15	;	;	:
cord-001293-dfaxj3bv	207	16	MARCO	MARCO	NNP
cord-001293-dfaxj3bv	207	17	:	:	:
cord-001293-dfaxj3bv	207	18	Macrophage	macrophage	NN
cord-001293-dfaxj3bv	207	19	-	-	HYPH
cord-001293-dfaxj3bv	207	20	associated	associate	VBN
cord-001293-dfaxj3bv	207	21	receptor	receptor	NN
cord-001293-dfaxj3bv	207	22	with	with	IN
cord-001293-dfaxj3bv	207	23	a	a	DT
cord-001293-dfaxj3bv	207	24	collagenous	collagenous	JJ
cord-001293-dfaxj3bv	207	25	base	base	NN
cord-001293-dfaxj3bv	207	26	;	;	:
cord-001293-dfaxj3bv	207	27	MOF	MOF	NNP
cord-001293-dfaxj3bv	207	28	:	:	:
cord-001293-dfaxj3bv	208	1	Multiple	multiple	JJ
cord-001293-dfaxj3bv	208	2	organ	organ	NN
cord-001293-dfaxj3bv	208	3	failure	failure	NN
cord-001293-dfaxj3bv	209	1	;	;	:
cord-001293-dfaxj3bv	209	2	NK	nk	NN
cord-001293-dfaxj3bv	209	3	:	:	:
cord-001293-dfaxj3bv	209	4	Natural	natural	JJ
cord-001293-dfaxj3bv	209	5	killer	killer	NN
cord-001293-dfaxj3bv	209	6	PD-1	PD-1	NNP
cord-001293-dfaxj3bv	209	7	:	:	:
cord-001293-dfaxj3bv	209	8	Programmed	program	VBN
cord-001293-dfaxj3bv	209	9	death-1	death-1	NNP
cord-001293-dfaxj3bv	209	10	;	;	:
cord-001293-dfaxj3bv	209	11	PD	PD	NNP
cord-001293-dfaxj3bv	209	12	-	-	HYPH
cord-001293-dfaxj3bv	209	13	L1	L1	NNP
cord-001293-dfaxj3bv	209	14	:	:	:
cord-001293-dfaxj3bv	209	15	Programmed	program	VBN
cord-001293-dfaxj3bv	209	16	death-1	death-1	NNP
cord-001293-dfaxj3bv	209	17	ligand	ligand	NN
cord-001293-dfaxj3bv	209	18	Prostaglandin	prostaglandin	NN
cord-001293-dfaxj3bv	209	19	E	e	NN
cord-001293-dfaxj3bv	209	20	2	2	CD
cord-001293-dfaxj3bv	209	21	;	;	:
cord-001293-dfaxj3bv	209	22	PM	pm	NN
cord-001293-dfaxj3bv	209	23	:	:	:
cord-001293-dfaxj3bv	209	24	Post	post	NN
cord-001293-dfaxj3bv	209	25	-	-	JJ
cord-001293-dfaxj3bv	209	26	mortem	mortem	JJ
cord-001293-dfaxj3bv	209	27	;	;	:
cord-001293-dfaxj3bv	209	28	SIRS	sirs	UH
cord-001293-dfaxj3bv	209	29	:	:	:
cord-001293-dfaxj3bv	210	1	Systemic	systemic	JJ
cord-001293-dfaxj3bv	210	2	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	210	3	response	response	NN
cord-001293-dfaxj3bv	210	4	syndrome	syndrome	NN
cord-001293-dfaxj3bv	210	5	;	;	:
cord-001293-dfaxj3bv	210	6	SR	SR	NNP
cord-001293-dfaxj3bv	210	7	-	-	HYPH
cord-001293-dfaxj3bv	210	8	A	A	NNP
cord-001293-dfaxj3bv	210	9	:	:	:
cord-001293-dfaxj3bv	210	10	Scavenger	Scavenger	NNP
cord-001293-dfaxj3bv	210	11	receptor	receptor	NN
cord-001293-dfaxj3bv	210	12	-	-	HYPH
cord-001293-dfaxj3bv	210	13	A	a	NN
cord-001293-dfaxj3bv	210	14	;	;	:
cord-001293-dfaxj3bv	210	15	TGFβ	TGFβ	NNP
cord-001293-dfaxj3bv	210	16	:	:	:
cord-001293-dfaxj3bv	211	1	Transforming	transform	VBG
cord-001293-dfaxj3bv	211	2	growth	growth	NN
cord-001293-dfaxj3bv	211	3	factor	factor	NN
cord-001293-dfaxj3bv	211	4	-	-	HYPH
cord-001293-dfaxj3bv	211	5	beta	beta	NN
cord-001293-dfaxj3bv	212	1	Th	th	JJ
cord-001293-dfaxj3bv	212	2	:	:	:
cord-001293-dfaxj3bv	212	3	T	T	NNP
cord-001293-dfaxj3bv	212	4	helper	helper	NN
cord-001293-dfaxj3bv	212	5	;	;	:
cord-001293-dfaxj3bv	212	6	TLR	tlr	NN
cord-001293-dfaxj3bv	212	7	:	:	:
cord-001293-dfaxj3bv	212	8	Toll	toll	NN
cord-001293-dfaxj3bv	212	9	-	-	HYPH
cord-001293-dfaxj3bv	212	10	like	like	JJ
cord-001293-dfaxj3bv	212	11	receptor	receptor	NN
cord-001293-dfaxj3bv	212	12	;	;	:
cord-001293-dfaxj3bv	212	13	TNF	tnf	NN
cord-001293-dfaxj3bv	212	14	:	:	:
cord-001293-dfaxj3bv	212	15	Tumor	tumor	NN
cord-001293-dfaxj3bv	212	16	necrosis	necrosis	NN
cord-001293-dfaxj3bv	212	17	factor	factor	NN
cord-001293-dfaxj3bv	212	18	;	;	:
cord-001293-dfaxj3bv	212	19	T	T	NNP
cord-001293-dfaxj3bv	212	20	reg	reg	NNP
cord-001293-dfaxj3bv	212	21	:	:	:
cord-001293-dfaxj3bv	212	22	Regulatory	regulatory	JJ
cord-001293-dfaxj3bv	212	23	T	t	NN
cord-001293-dfaxj3bv	212	24	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	212	25	;	;	:
cord-001293-dfaxj3bv	212	26	VAP	VAP	NNP
cord-001293-dfaxj3bv	212	27	:	:	:
cord-001293-dfaxj3bv	212	28	Ventilator	ventilator	NN
cord-001293-dfaxj3bv	212	29	-	-	HYPH
cord-001293-dfaxj3bv	212	30	associated	associate	VBN
cord-001293-dfaxj3bv	212	31	pneumonia	pneumonia	NN
cord-001293-dfaxj3bv	212	32	Immunosuppression	Immunosuppression	NNP
cord-001293-dfaxj3bv	212	33	in	in	IN
cord-001293-dfaxj3bv	212	34	sepsis	sepsis	NN
cord-001293-dfaxj3bv	212	35	:	:	:
cord-001293-dfaxj3bv	212	36	a	a	DT
cord-001293-dfaxj3bv	212	37	novel	novel	JJ
cord-001293-dfaxj3bv	212	38	understanding	understanding	NN
cord-001293-dfaxj3bv	212	39	of	of	IN
cord-001293-dfaxj3bv	212	40	the	the	DT
cord-001293-dfaxj3bv	212	41	disorder	disorder	NN
cord-001293-dfaxj3bv	212	42	and	and	CC
cord-001293-dfaxj3bv	212	43	a	a	DT
cord-001293-dfaxj3bv	212	44	new	new	JJ
cord-001293-dfaxj3bv	212	45	therapeutic	therapeutic	JJ
cord-001293-dfaxj3bv	212	46	approach	approach	NN
cord-001293-dfaxj3bv	212	47	Paradoxical	paradoxical	JJ
cord-001293-dfaxj3bv	212	48	anti	anti	JJ
cord-001293-dfaxj3bv	212	49	-	-	JJ
cord-001293-dfaxj3bv	212	50	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	212	51	actions	action	NNS
cord-001293-dfaxj3bv	212	52	of	of	IN
cord-001293-dfaxj3bv	212	53	TNF	TNF	NNP
cord-001293-dfaxj3bv	212	54	-	-	HYPH
cord-001293-dfaxj3bv	212	55	alpha	alpha	NN
cord-001293-dfaxj3bv	212	56	:	:	:
cord-001293-dfaxj3bv	212	57	inhibition	inhibition	NN
cord-001293-dfaxj3bv	212	58	of	of	IN
cord-001293-dfaxj3bv	212	59	IL-12	IL-12	NNP
cord-001293-dfaxj3bv	212	60	and	and	CC
cord-001293-dfaxj3bv	212	61	IL-23	IL-23	NNP
cord-001293-dfaxj3bv	212	62	via	via	IN
cord-001293-dfaxj3bv	212	63	TNF	TNF	NNP
cord-001293-dfaxj3bv	212	64	receptor	receptor	NN
cord-001293-dfaxj3bv	212	65	1	1	CD
cord-001293-dfaxj3bv	212	66	in	in	IN
cord-001293-dfaxj3bv	212	67	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	212	68	and	and	CC
cord-001293-dfaxj3bv	212	69	dendritic	dendritic	JJ
cord-001293-dfaxj3bv	212	70	cells	cell	NNS
cord-001293-dfaxj3bv	213	1	TNF	TNF	NNP
cord-001293-dfaxj3bv	213	2	suppresses	suppress	VBZ
cord-001293-dfaxj3bv	213	3	acute	acute	JJ
cord-001293-dfaxj3bv	213	4	intestinal	intestinal	JJ
cord-001293-dfaxj3bv	213	5	inflammation	inflammation	NN
cord-001293-dfaxj3bv	213	6	by	by	IN
cord-001293-dfaxj3bv	213	7	inducing	induce	VBG
cord-001293-dfaxj3bv	213	8	local	local	JJ
cord-001293-dfaxj3bv	213	9	glucocorticoid	glucocorticoid	NN
cord-001293-dfaxj3bv	213	10	synthesis	synthesis	NN
cord-001293-dfaxj3bv	214	1	Interleukin	interleukin	NN
cord-001293-dfaxj3bv	214	2	1	1	CD
cord-001293-dfaxj3bv	214	3	receptor	receptor	NN
cord-001293-dfaxj3bv	214	4	signaling	signaling	NN
cord-001293-dfaxj3bv	214	5	regulates	regulate	VBZ
cord-001293-dfaxj3bv	214	6	DUBA	DUBA	NNP
cord-001293-dfaxj3bv	214	7	expression	expression	NN
cord-001293-dfaxj3bv	214	8	and	and	CC
cord-001293-dfaxj3bv	214	9	facilitates	facilitate	VBZ
cord-001293-dfaxj3bv	214	10	toll	toll	NN
cord-001293-dfaxj3bv	214	11	-	-	HYPH
cord-001293-dfaxj3bv	214	12	like	like	JJ
cord-001293-dfaxj3bv	214	13	receptor	receptor	NN
cord-001293-dfaxj3bv	214	14	9-driven	9-driven	CD
cord-001293-dfaxj3bv	214	15	antiinflammatory	antiinflammatory	JJ
cord-001293-dfaxj3bv	214	16	cytokine	cytokine	NN
cord-001293-dfaxj3bv	214	17	production	production	NN
cord-001293-dfaxj3bv	215	1	Systemic	systemic	JJ
cord-001293-dfaxj3bv	215	2	interferon	interferon	NN
cord-001293-dfaxj3bv	215	3	-	-	HYPH
cord-001293-dfaxj3bv	215	4	gamma	gamma	NN
cord-001293-dfaxj3bv	215	5	suppresses	suppress	VBZ
cord-001293-dfaxj3bv	215	6	the	the	DT
cord-001293-dfaxj3bv	215	7	development	development	NN
cord-001293-dfaxj3bv	215	8	of	of	IN
cord-001293-dfaxj3bv	215	9	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	215	10	-	-	HYPH
cord-001293-dfaxj3bv	215	11	induced	induce	VBN
cord-001293-dfaxj3bv	215	12	uveitis	uveitis	NN
cord-001293-dfaxj3bv	215	13	in	in	IN
cord-001293-dfaxj3bv	215	14	mice	mouse	NNS
cord-001293-dfaxj3bv	215	15	Proinflammatory	Proinflammatory	NNP
cord-001293-dfaxj3bv	215	16	effects	effect	NNS
cord-001293-dfaxj3bv	215	17	of	of	IN
cord-001293-dfaxj3bv	215	18	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	215	19	during	during	IN
cord-001293-dfaxj3bv	215	20	human	human	JJ
cord-001293-dfaxj3bv	215	21	endotoxemia	endotoxemia	NN
cord-001293-dfaxj3bv	216	1	Adib-	Adib-	NNP
cord-001293-dfaxj3bv	217	1	Conquy	Conquy	NNP
cord-001293-dfaxj3bv	217	2	M	M	NNP
cord-001293-dfaxj3bv	217	3	:	:	:
cord-001293-dfaxj3bv	217	4	Adherence	adherence	NN
cord-001293-dfaxj3bv	217	5	modifies	modify	VBZ
cord-001293-dfaxj3bv	217	6	the	the	DT
cord-001293-dfaxj3bv	217	7	regulation	regulation	NN
cord-001293-dfaxj3bv	217	8	of	of	IN
cord-001293-dfaxj3bv	217	9	gene	gene	NN
cord-001293-dfaxj3bv	217	10	expression	expression	NN
cord-001293-dfaxj3bv	217	11	induced	induce	VBN
cord-001293-dfaxj3bv	217	12	by	by	IN
cord-001293-dfaxj3bv	217	13	interleukin-10	interleukin-10	NNP
cord-001293-dfaxj3bv	217	14	A	a	NN
cord-001293-dfaxj3bv	217	15	:	:	:
cord-001293-dfaxj3bv	218	1	Interleukin-10	Interleukin-10	NNP
cord-001293-dfaxj3bv	218	2	and	and	CC
cord-001293-dfaxj3bv	218	3	the	the	DT
cord-001293-dfaxj3bv	218	4	interleukin-10	interleukin-10	NNP
cord-001293-dfaxj3bv	218	5	receptor	receptor	NN
cord-001293-dfaxj3bv	218	6	Hepatic	hepatic	JJ
cord-001293-dfaxj3bv	218	7	over	over	IN
cord-001293-dfaxj3bv	218	8	-	-	HYPH
cord-001293-dfaxj3bv	218	9	expression	expression	NN
cord-001293-dfaxj3bv	218	10	of	of	IN
cord-001293-dfaxj3bv	218	11	TGF	TGF	NNP
cord-001293-dfaxj3bv	218	12	-	-	HYPH
cord-001293-dfaxj3bv	218	13	beta1	beta1	NN
cord-001293-dfaxj3bv	218	14	promotes	promote	VBZ
cord-001293-dfaxj3bv	218	15	LPS	LPS	NNP
cord-001293-dfaxj3bv	218	16	-	-	HYPH
cord-001293-dfaxj3bv	218	17	induced	induce	VBN
cord-001293-dfaxj3bv	218	18	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	218	19	cytokine	cytokine	NN
cord-001293-dfaxj3bv	218	20	secretion	secretion	NN
cord-001293-dfaxj3bv	218	21	by	by	IN
cord-001293-dfaxj3bv	218	22	liver	liver	NN
cord-001293-dfaxj3bv	218	23	cells	cell	NNS
cord-001293-dfaxj3bv	218	24	and	and	CC
cord-001293-dfaxj3bv	218	25	endotoxemic	endotoxemic	JJ
cord-001293-dfaxj3bv	218	26	shock	shock	NN
cord-001293-dfaxj3bv	218	27	Regulation	regulation	NN
cord-001293-dfaxj3bv	218	28	of	of	IN
cord-001293-dfaxj3bv	218	29	immune	immune	JJ
cord-001293-dfaxj3bv	218	30	responses	response	NNS
cord-001293-dfaxj3bv	218	31	by	by	IN
cord-001293-dfaxj3bv	218	32	prostaglandin	prostaglandin	NN
cord-001293-dfaxj3bv	218	33	E2	E2	NNP
cord-001293-dfaxj3bv	218	34	Efficacy	Efficacy	NNP
cord-001293-dfaxj3bv	218	35	and	and	CC
cord-001293-dfaxj3bv	218	36	safety	safety	NN
cord-001293-dfaxj3bv	218	37	of	of	IN
cord-001293-dfaxj3bv	218	38	monoclonal	monoclonal	JJ
cord-001293-dfaxj3bv	218	39	antibody	antibody	NN
cord-001293-dfaxj3bv	218	40	to	to	IN
cord-001293-dfaxj3bv	218	41	human	human	JJ
cord-001293-dfaxj3bv	218	42	tumor	tumor	NN
cord-001293-dfaxj3bv	218	43	necrosis	necrosis	NN
cord-001293-dfaxj3bv	218	44	factor	factor	NN
cord-001293-dfaxj3bv	218	45	alpha	alpha	NN
cord-001293-dfaxj3bv	218	46	in	in	IN
cord-001293-dfaxj3bv	218	47	patients	patient	NNS
cord-001293-dfaxj3bv	218	48	with	with	IN
cord-001293-dfaxj3bv	218	49	sepsis	sepsis	NN
cord-001293-dfaxj3bv	218	50	syndrome	syndrome	NN
cord-001293-dfaxj3bv	218	51	.	.	.
cord-001293-dfaxj3bv	219	1	A	a	DT
cord-001293-dfaxj3bv	219	2	randomized	randomized	JJ
cord-001293-dfaxj3bv	219	3	,	,	,
cord-001293-dfaxj3bv	219	4	controlled	control	VBN
cord-001293-dfaxj3bv	219	5	,	,	,
cord-001293-dfaxj3bv	219	6	double	double	JJ
cord-001293-dfaxj3bv	219	7	-	-	HYPH
cord-001293-dfaxj3bv	219	8	blind	blind	JJ
cord-001293-dfaxj3bv	219	9	,	,	,
cord-001293-dfaxj3bv	219	10	multicenter	multicenter	JJ
cord-001293-dfaxj3bv	219	11	clinical	clinical	JJ
cord-001293-dfaxj3bv	219	12	trial	trial	NN
cord-001293-dfaxj3bv	219	13	.	.	.
cord-001293-dfaxj3bv	220	1	TNF	tnf	NN
cord-001293-dfaxj3bv	220	2	-	-	HYPH
cord-001293-dfaxj3bv	220	3	alpha	alpha	NN
cord-001293-dfaxj3bv	220	4	MAb	MAb	NNS
cord-001293-dfaxj3bv	220	5	sepsis	sepsis	NN
cord-001293-dfaxj3bv	220	6	study	study	NN
cord-001293-dfaxj3bv	220	7	group	group	NN
cord-001293-dfaxj3bv	220	8	Assessment	Assessment	NNP
cord-001293-dfaxj3bv	220	9	of	of	IN
cord-001293-dfaxj3bv	220	10	the	the	DT
cord-001293-dfaxj3bv	220	11	safety	safety	NN
cord-001293-dfaxj3bv	220	12	and	and	CC
cord-001293-dfaxj3bv	220	13	efficacy	efficacy	NN
cord-001293-dfaxj3bv	220	14	of	of	IN
cord-001293-dfaxj3bv	220	15	the	the	DT
cord-001293-dfaxj3bv	220	16	monoclonal	monoclonal	JJ
cord-001293-dfaxj3bv	220	17	anti	anti	JJ
cord-001293-dfaxj3bv	220	18	-	-	JJ
cord-001293-dfaxj3bv	220	19	tumor	tumor	JJ
cord-001293-dfaxj3bv	220	20	necrosis	necrosis	NN
cord-001293-dfaxj3bv	220	21	factor	factor	NN
cord-001293-dfaxj3bv	220	22	antibody	antibody	NN
cord-001293-dfaxj3bv	220	23	-	-	HYPH
cord-001293-dfaxj3bv	220	24	fragment	fragment	NN
cord-001293-dfaxj3bv	220	25	,	,	,
cord-001293-dfaxj3bv	220	26	MAK	MAK	NNP
cord-001293-dfaxj3bv	220	27	195	195	CD
cord-001293-dfaxj3bv	220	28	F	F	NNP
cord-001293-dfaxj3bv	220	29	,	,	,
cord-001293-dfaxj3bv	220	30	in	in	IN
cord-001293-dfaxj3bv	220	31	patients	patient	NNS
cord-001293-dfaxj3bv	220	32	with	with	IN
cord-001293-dfaxj3bv	220	33	sepsis	sepsis	NN
cord-001293-dfaxj3bv	220	34	and	and	CC
cord-001293-dfaxj3bv	220	35	septic	septic	JJ
cord-001293-dfaxj3bv	220	36	shock	shock	NN
cord-001293-dfaxj3bv	220	37	:	:	:
cord-001293-dfaxj3bv	220	38	a	a	DT
cord-001293-dfaxj3bv	220	39	multicenter	multicenter	NN
cord-001293-dfaxj3bv	220	40	,	,	,
cord-001293-dfaxj3bv	220	41	randomized	randomized	JJ
cord-001293-dfaxj3bv	220	42	,	,	,
cord-001293-dfaxj3bv	220	43	placebo	placebo	NN
cord-001293-dfaxj3bv	220	44	-	-	HYPH
cord-001293-dfaxj3bv	220	45	controlled	control	VBN
cord-001293-dfaxj3bv	220	46	,	,	,
cord-001293-dfaxj3bv	220	47	dose	dose	NN
cord-001293-dfaxj3bv	220	48	-	-	HYPH
cord-001293-dfaxj3bv	220	49	ranging	range	VBG
cord-001293-dfaxj3bv	220	50	study	study	NN
cord-001293-dfaxj3bv	220	51	Continuous	continuous	JJ
cord-001293-dfaxj3bv	220	52	plasmafiltration	plasmafiltration	NN
cord-001293-dfaxj3bv	220	53	coupled	couple	VBN
cord-001293-dfaxj3bv	220	54	with	with	IN
cord-001293-dfaxj3bv	220	55	sorbent	sorbent	NN
cord-001293-dfaxj3bv	220	56	adsorption	adsorption	NN
cord-001293-dfaxj3bv	220	57	in	in	IN
cord-001293-dfaxj3bv	220	58	a	a	DT
cord-001293-dfaxj3bv	220	59	rabbit	rabbit	NN
cord-001293-dfaxj3bv	220	60	model	model	NN
cord-001293-dfaxj3bv	220	61	of	of	IN
cord-001293-dfaxj3bv	220	62	endotoxic	endotoxic	JJ
cord-001293-dfaxj3bv	220	63	shock	shock	NN
cord-001293-dfaxj3bv	220	64	Neutralization	neutralization	NN
cord-001293-dfaxj3bv	220	65	of	of	IN
cord-001293-dfaxj3bv	220	66	tumor	tumor	NN
cord-001293-dfaxj3bv	220	67	necrosis	necrosis	NN
cord-001293-dfaxj3bv	220	68	factor	factor	NN
cord-001293-dfaxj3bv	220	69	in	in	IN
cord-001293-dfaxj3bv	220	70	preclinical	preclinical	JJ
cord-001293-dfaxj3bv	220	71	models	model	NNS
cord-001293-dfaxj3bv	220	72	of	of	IN
cord-001293-dfaxj3bv	220	73	sepsis	sepsis	NN
cord-001293-dfaxj3bv	221	1	Interferon	interferon	NN
cord-001293-dfaxj3bv	221	2	-	-	HYPH
cord-001293-dfaxj3bv	221	3	gamma	gamma	NN
cord-001293-dfaxj3bv	221	4	increases	increase	NNS
cord-001293-dfaxj3bv	221	5	mortality	mortality	NN
cord-001293-dfaxj3bv	221	6	following	follow	VBG
cord-001293-dfaxj3bv	221	7	cecal	cecal	JJ
cord-001293-dfaxj3bv	221	8	ligation	ligation	NN
cord-001293-dfaxj3bv	221	9	and	and	CC
cord-001293-dfaxj3bv	221	10	puncture	puncture	NN
cord-001293-dfaxj3bv	221	11	Granulocytemacrophage	Granulocytemacrophage	NNP
cord-001293-dfaxj3bv	221	12	-	-	HYPH
cord-001293-dfaxj3bv	221	13	colony	colony	NN
cord-001293-dfaxj3bv	221	14	-	-	HYPH
cord-001293-dfaxj3bv	221	15	stimulating	stimulate	VBG
cord-001293-dfaxj3bv	221	16	factor	factor	NN
cord-001293-dfaxj3bv	221	17	-	-	HYPH
cord-001293-dfaxj3bv	221	18	dependent	dependent	JJ
cord-001293-dfaxj3bv	221	19	peritoneal	peritoneal	JJ
cord-001293-dfaxj3bv	221	20	macrophage	macrophage	NN
cord-001293-dfaxj3bv	221	21	responses	response	NNS
cord-001293-dfaxj3bv	221	22	determine	determine	VBP
cord-001293-dfaxj3bv	221	23	survival	survival	NN
cord-001293-dfaxj3bv	221	24	in	in	IN
cord-001293-dfaxj3bv	221	25	experimentally	experimentally	RB
cord-001293-dfaxj3bv	221	26	induced	induce	VBN
cord-001293-dfaxj3bv	221	27	peritonitis	peritonitis	NN
cord-001293-dfaxj3bv	221	28	and	and	CC
cord-001293-dfaxj3bv	221	29	sepsis	sepsis	NN
cord-001293-dfaxj3bv	221	30	in	in	IN
cord-001293-dfaxj3bv	221	31	mice	mouse	NNS
cord-001293-dfaxj3bv	222	1	Role	role	NN
cord-001293-dfaxj3bv	222	2	of	of	IN
cord-001293-dfaxj3bv	222	3	T	T	NNP
cord-001293-dfaxj3bv	222	4	cells	cell	NNS
cord-001293-dfaxj3bv	222	5	for	for	IN
cord-001293-dfaxj3bv	222	6	cytokine	cytokine	NN
cord-001293-dfaxj3bv	222	7	production	production	NN
cord-001293-dfaxj3bv	222	8	and	and	CC
cord-001293-dfaxj3bv	222	9	outcome	outcome	NN
cord-001293-dfaxj3bv	222	10	in	in	IN
cord-001293-dfaxj3bv	222	11	a	a	DT
cord-001293-dfaxj3bv	222	12	model	model	NN
cord-001293-dfaxj3bv	222	13	of	of	IN
cord-001293-dfaxj3bv	222	14	acute	acute	JJ
cord-001293-dfaxj3bv	222	15	septic	septic	JJ
cord-001293-dfaxj3bv	222	16	peritonitis	peritonitis	NN
cord-001293-dfaxj3bv	222	17	Role	role	NN
cord-001293-dfaxj3bv	222	18	of	of	IN
cord-001293-dfaxj3bv	222	19	T	T	NNP
cord-001293-dfaxj3bv	222	20	cells	cell	NNS
cord-001293-dfaxj3bv	222	21	in	in	IN
cord-001293-dfaxj3bv	222	22	a	a	DT
cord-001293-dfaxj3bv	222	23	murine	murine	JJ
cord-001293-dfaxj3bv	222	24	model	model	NN
cord-001293-dfaxj3bv	222	25	of	of	IN
cord-001293-dfaxj3bv	222	26	Escherichia	Escherichia	NNP
cord-001293-dfaxj3bv	222	27	coli	coli	NNS
cord-001293-dfaxj3bv	222	28	sepsis	sepsis	NN
cord-001293-dfaxj3bv	222	29	Adoptive	adoptive	JJ
cord-001293-dfaxj3bv	222	30	transfer	transfer	NN
cord-001293-dfaxj3bv	222	31	of	of	IN
cord-001293-dfaxj3bv	222	32	in	in	IN
cord-001293-dfaxj3bv	222	33	vitro	vitro	FW
cord-001293-dfaxj3bv	222	34	-	-	HYPH
cord-001293-dfaxj3bv	222	35	stimulated	stimulate	VBN
cord-001293-dfaxj3bv	222	36	CD4	CD4	NNP
cord-001293-dfaxj3bv	222	37	+	+	CC
cord-001293-dfaxj3bv	222	38	CD25	cd25	NN
cord-001293-dfaxj3bv	222	39	+	+	CC
cord-001293-dfaxj3bv	222	40	regulatory	regulatory	JJ
cord-001293-dfaxj3bv	222	41	T	t	NN
cord-001293-dfaxj3bv	222	42	cells	cell	NNS
cord-001293-dfaxj3bv	222	43	increases	increase	VBZ
cord-001293-dfaxj3bv	222	44	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	222	45	clearance	clearance	NN
cord-001293-dfaxj3bv	222	46	and	and	CC
cord-001293-dfaxj3bv	222	47	improves	improve	VBZ
cord-001293-dfaxj3bv	222	48	survival	survival	NN
cord-001293-dfaxj3bv	222	49	in	in	IN
cord-001293-dfaxj3bv	222	50	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	222	51	sepsis	sepsis	NN
cord-001293-dfaxj3bv	222	52	Neutralization	neutralization	NN
cord-001293-dfaxj3bv	222	53	of	of	IN
cord-001293-dfaxj3bv	222	54	interleukin-10	interleukin-10	NN
cord-001293-dfaxj3bv	222	55	or	or	CC
cord-001293-dfaxj3bv	222	56	transforming	transform	VBG
cord-001293-dfaxj3bv	222	57	growth	growth	NN
cord-001293-dfaxj3bv	222	58	factor	factor	NN
cord-001293-dfaxj3bv	222	59	-	-	HYPH
cord-001293-dfaxj3bv	222	60	beta	beta	NN
cord-001293-dfaxj3bv	222	61	decreases	decrease	VBZ
cord-001293-dfaxj3bv	222	62	the	the	DT
cord-001293-dfaxj3bv	222	63	percentages	percentage	NNS
cord-001293-dfaxj3bv	222	64	of	of	IN
cord-001293-dfaxj3bv	222	65	CD4	CD4	NNP
cord-001293-dfaxj3bv	222	66	+	+	CC
cord-001293-dfaxj3bv	223	1	CD25	cd25	NN
cord-001293-dfaxj3bv	223	2	+	+	CC
cord-001293-dfaxj3bv	224	1	Foxp3	foxp3	JJ
cord-001293-dfaxj3bv	224	2	+	+	CC
cord-001293-dfaxj3bv	224	3	regulatory	regulatory	JJ
cord-001293-dfaxj3bv	224	4	T	T	NNP
cord-001293-dfaxj3bv	224	5	cells	cell	NNS
cord-001293-dfaxj3bv	224	6	in	in	IN
cord-001293-dfaxj3bv	224	7	septic	septic	JJ
cord-001293-dfaxj3bv	224	8	mice	mouse	NNS
cord-001293-dfaxj3bv	224	9	,	,	,
cord-001293-dfaxj3bv	224	10	thereby	thereby	RB
cord-001293-dfaxj3bv	224	11	leading	lead	VBG
cord-001293-dfaxj3bv	224	12	to	to	IN
cord-001293-dfaxj3bv	224	13	an	an	DT
cord-001293-dfaxj3bv	224	14	improved	improve	VBN
cord-001293-dfaxj3bv	224	15	survival	survival	NN
cord-001293-dfaxj3bv	224	16	Natural	natural	JJ
cord-001293-dfaxj3bv	224	17	killer	killer	NN
cord-001293-dfaxj3bv	224	18	(	(	-LRB-
cord-001293-dfaxj3bv	224	19	NK	NK	NNP
cord-001293-dfaxj3bv	224	20	)	)	-RRB-
cord-001293-dfaxj3bv	224	21	cells	cell	NNS
cord-001293-dfaxj3bv	224	22	in	in	IN
cord-001293-dfaxj3bv	224	23	antibacterial	antibacterial	JJ
cord-001293-dfaxj3bv	224	24	innate	innate	JJ
cord-001293-dfaxj3bv	224	25	immunity	immunity	NN
cord-001293-dfaxj3bv	224	26	:	:	:
cord-001293-dfaxj3bv	224	27	angels	angel	NNS
cord-001293-dfaxj3bv	224	28	or	or	CC
cord-001293-dfaxj3bv	224	29	devils	devil	NNS
cord-001293-dfaxj3bv	224	30	CD11c	CD11c	NNP
cord-001293-dfaxj3bv	224	31	+	+	CD
cord-001293-dfaxj3bv	224	32	dendritic	dendritic	JJ
cord-001293-dfaxj3bv	224	33	cells	cell	NNS
cord-001293-dfaxj3bv	224	34	are	be	VBP
cord-001293-dfaxj3bv	224	35	required	require	VBN
cord-001293-dfaxj3bv	224	36	for	for	IN
cord-001293-dfaxj3bv	224	37	survival	survival	NN
cord-001293-dfaxj3bv	224	38	in	in	IN
cord-001293-dfaxj3bv	224	39	murine	murine	JJ
cord-001293-dfaxj3bv	224	40	polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	224	41	sepsis	sepsis	NN
cord-001293-dfaxj3bv	224	42	Altered	alter	VBN
cord-001293-dfaxj3bv	224	43	gene	gene	NN
cord-001293-dfaxj3bv	224	44	expression	expression	NN
cord-001293-dfaxj3bv	224	45	patterns	pattern	NNS
cord-001293-dfaxj3bv	224	46	in	in	IN
cord-001293-dfaxj3bv	224	47	dendritic	dendritic	JJ
cord-001293-dfaxj3bv	224	48	cells	cell	NNS
cord-001293-dfaxj3bv	224	49	after	after	IN
cord-001293-dfaxj3bv	224	50	severe	severe	JJ
cord-001293-dfaxj3bv	224	51	trauma	trauma	NN
cord-001293-dfaxj3bv	224	52	:	:	:
cord-001293-dfaxj3bv	224	53	implications	implication	NNS
cord-001293-dfaxj3bv	224	54	for	for	IN
cord-001293-dfaxj3bv	224	55	systemic	systemic	JJ
cord-001293-dfaxj3bv	224	56	inflammation	inflammation	NN
cord-001293-dfaxj3bv	224	57	and	and	CC
cord-001293-dfaxj3bv	224	58	organ	organ	NN
cord-001293-dfaxj3bv	224	59	injury	injury	NN
cord-001293-dfaxj3bv	224	60	Overexpression	Overexpression	NNP
cord-001293-dfaxj3bv	224	61	of	of	IN
cord-001293-dfaxj3bv	224	62	Bcl-2	Bcl-2	NNP
cord-001293-dfaxj3bv	224	63	in	in	IN
cord-001293-dfaxj3bv	224	64	transgenic	transgenic	JJ
cord-001293-dfaxj3bv	224	65	mice	mice	NN
cord-001293-dfaxj3bv	224	66	decreases	decrease	VBZ
cord-001293-dfaxj3bv	224	67	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	224	68	and	and	CC
cord-001293-dfaxj3bv	224	69	improves	improve	VBZ
cord-001293-dfaxj3bv	224	70	survival	survival	NN
cord-001293-dfaxj3bv	224	71	in	in	IN
cord-001293-dfaxj3bv	224	72	sepsis	sepsis	NN
cord-001293-dfaxj3bv	225	1	TGF	TGF	NNP
cord-001293-dfaxj3bv	225	2	-	-	HYPH
cord-001293-dfaxj3bv	225	3	beta	beta	NN
cord-001293-dfaxj3bv	225	4	released	release	VBN
cord-001293-dfaxj3bv	225	5	by	by	IN
cord-001293-dfaxj3bv	225	6	apoptotic	apoptotic	JJ
cord-001293-dfaxj3bv	225	7	T	t	NN
cord-001293-dfaxj3bv	225	8	cells	cell	NNS
cord-001293-dfaxj3bv	225	9	contributes	contribute	VBZ
cord-001293-dfaxj3bv	225	10	to	to	IN
cord-001293-dfaxj3bv	225	11	an	an	DT
cord-001293-dfaxj3bv	225	12	immunosuppressive	immunosuppressive	JJ
cord-001293-dfaxj3bv	225	13	milieu	milieu	NN
cord-001293-dfaxj3bv	225	14	Apoptotic	Apoptotic	NNP
cord-001293-dfaxj3bv	225	15	cells	cell	NNS
cord-001293-dfaxj3bv	225	16	protect	protect	VBP
cord-001293-dfaxj3bv	225	17	mice	mouse	NNS
cord-001293-dfaxj3bv	225	18	against	against	IN
cord-001293-dfaxj3bv	225	19	lipopolysaccharide	lipopolysaccharide	NN
cord-001293-dfaxj3bv	225	20	-	-	HYPH
cord-001293-dfaxj3bv	225	21	induced	induce	VBN
cord-001293-dfaxj3bv	225	22	shock	shock	NN
cord-001293-dfaxj3bv	226	1	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-001293-dfaxj3bv	226	2	induces	induce	VBZ
cord-001293-dfaxj3bv	226	3	rapid	rapid	JJ
cord-001293-dfaxj3bv	226	4	production	production	NN
cord-001293-dfaxj3bv	226	5	of	of	IN
cord-001293-dfaxj3bv	227	1	IL-10	IL-10	NNP
cord-001293-dfaxj3bv	227	2	by	by	IN
cord-001293-dfaxj3bv	227	3	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	227	4	in	in	IN
cord-001293-dfaxj3bv	227	5	the	the	DT
cord-001293-dfaxj3bv	227	6	presence	presence	NN
cord-001293-dfaxj3bv	227	7	of	of	IN
cord-001293-dfaxj3bv	227	8	apoptotic	apoptotic	JJ
cord-001293-dfaxj3bv	227	9	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	227	10	Silencing	silencing	NN
cord-001293-dfaxj3bv	227	11	of	of	IN
cord-001293-dfaxj3bv	227	12	Fas	Fas	NNP
cord-001293-dfaxj3bv	227	13	,	,	,
cord-001293-dfaxj3bv	227	14	but	but	CC
cord-001293-dfaxj3bv	227	15	not	not	RB
cord-001293-dfaxj3bv	227	16	caspase-8	caspase-8	JJ
cord-001293-dfaxj3bv	227	17	,	,	,
cord-001293-dfaxj3bv	227	18	in	in	IN
cord-001293-dfaxj3bv	227	19	lung	lung	NN
cord-001293-dfaxj3bv	227	20	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	227	21	cells	cell	NNS
cord-001293-dfaxj3bv	227	22	ameliorates	ameliorate	VBZ
cord-001293-dfaxj3bv	227	23	pulmonary	pulmonary	JJ
cord-001293-dfaxj3bv	227	24	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	227	25	,	,	,
cord-001293-dfaxj3bv	227	26	inflammation	inflammation	NN
cord-001293-dfaxj3bv	227	27	,	,	,
cord-001293-dfaxj3bv	227	28	and	and	CC
cord-001293-dfaxj3bv	227	29	neutrophil	neutrophil	NN
cord-001293-dfaxj3bv	227	30	influx	influx	NN
cord-001293-dfaxj3bv	227	31	after	after	IN
cord-001293-dfaxj3bv	227	32	hemorrhagic	hemorrhagic	JJ
cord-001293-dfaxj3bv	227	33	shock	shock	NN
cord-001293-dfaxj3bv	227	34	and	and	CC
cord-001293-dfaxj3bv	227	35	sepsis	sepsis	NN
cord-001293-dfaxj3bv	227	36	Inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	227	37	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	227	38	induce	induce	VBP
cord-001293-dfaxj3bv	227	39	apoptotic	apoptotic	JJ
cord-001293-dfaxj3bv	227	40	and	and	CC
cord-001293-dfaxj3bv	227	41	necrotic	necrotic	JJ
cord-001293-dfaxj3bv	227	42	cell	cell	NN
cord-001293-dfaxj3bv	227	43	shedding	shed	VBG
cord-001293-dfaxj3bv	227	44	from	from	IN
cord-001293-dfaxj3bv	227	45	human	human	JJ
cord-001293-dfaxj3bv	227	46	proximal	proximal	JJ
cord-001293-dfaxj3bv	227	47	tubular	tubular	JJ
cord-001293-dfaxj3bv	227	48	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	227	49	cell	cell	NN
cord-001293-dfaxj3bv	227	50	monolayers	monolayer	NNS
cord-001293-dfaxj3bv	227	51	Mechanisms	mechanism	NNS
cord-001293-dfaxj3bv	227	52	of	of	IN
cord-001293-dfaxj3bv	227	53	decreased	decrease	VBN
cord-001293-dfaxj3bv	227	54	intestinal	intestinal	JJ
cord-001293-dfaxj3bv	227	55	epithelial	epithelial	JJ
cord-001293-dfaxj3bv	227	56	proliferation	proliferation	NN
cord-001293-dfaxj3bv	227	57	and	and	CC
cord-001293-dfaxj3bv	227	58	increased	increase	VBN
cord-001293-dfaxj3bv	227	59	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	227	60	in	in	IN
cord-001293-dfaxj3bv	228	1	murine	murine	JJ
cord-001293-dfaxj3bv	228	2	acute	acute	JJ
cord-001293-dfaxj3bv	228	3	lung	lung	NN
cord-001293-dfaxj3bv	228	4	injury	injury	NN
cord-001293-dfaxj3bv	228	5	Apoptosis	Apoptosis	NNP
cord-001293-dfaxj3bv	228	6	contributes	contribute	VBZ
cord-001293-dfaxj3bv	228	7	to	to	IN
cord-001293-dfaxj3bv	228	8	septic	septic	JJ
cord-001293-dfaxj3bv	228	9	cardiomyopathy	cardiomyopathy	NN
cord-001293-dfaxj3bv	228	10	and	and	CC
cord-001293-dfaxj3bv	228	11	is	be	VBZ
cord-001293-dfaxj3bv	228	12	improved	improve	VBN
cord-001293-dfaxj3bv	228	13	by	by	IN
cord-001293-dfaxj3bv	229	1	simvastatin	simvastatin	NN
cord-001293-dfaxj3bv	229	2	therapy	therapy	NN
cord-001293-dfaxj3bv	229	3	Adrenomedullin	Adrenomedullin	NNP
cord-001293-dfaxj3bv	229	4	and	and	CC
cord-001293-dfaxj3bv	229	5	adrenomedullin	adrenomedullin	NNP
cord-001293-dfaxj3bv	229	6	binding	bind	VBG
cord-001293-dfaxj3bv	229	7	protein-1	protein-1	NNP
cord-001293-dfaxj3bv	229	8	attenuate	attenuate	VBP
cord-001293-dfaxj3bv	229	9	vascular	vascular	JJ
cord-001293-dfaxj3bv	229	10	endothelial	endothelial	JJ
cord-001293-dfaxj3bv	229	11	cell	cell	NN
cord-001293-dfaxj3bv	229	12	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	229	13	in	in	IN
cord-001293-dfaxj3bv	229	14	sepsis	sepsis	NN
cord-001293-dfaxj3bv	229	15	Apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	229	16	of	of	IN
cord-001293-dfaxj3bv	229	17	neurons	neuron	NNS
cord-001293-dfaxj3bv	229	18	in	in	IN
cord-001293-dfaxj3bv	229	19	cardiovascular	cardiovascular	JJ
cord-001293-dfaxj3bv	229	20	autonomic	autonomic	JJ
cord-001293-dfaxj3bv	229	21	centres	centre	NNS
cord-001293-dfaxj3bv	229	22	triggered	trigger	VBN
cord-001293-dfaxj3bv	229	23	by	by	IN
cord-001293-dfaxj3bv	229	24	inducible	inducible	JJ
cord-001293-dfaxj3bv	229	25	nitric	nitric	NN
cord-001293-dfaxj3bv	229	26	oxide	oxide	NN
cord-001293-dfaxj3bv	229	27	synthase	synthase	NN
cord-001293-dfaxj3bv	229	28	after	after	IN
cord-001293-dfaxj3bv	229	29	death	death	NN
cord-001293-dfaxj3bv	229	30	from	from	IN
cord-001293-dfaxj3bv	229	31	septic	septic	JJ
cord-001293-dfaxj3bv	229	32	shock	shock	NN
cord-001293-dfaxj3bv	229	33	Opposing	oppose	VBG
cord-001293-dfaxj3bv	229	34	and	and	CC
cord-001293-dfaxj3bv	229	35	hierarchical	hierarchical	JJ
cord-001293-dfaxj3bv	229	36	roles	role	NNS
cord-001293-dfaxj3bv	229	37	of	of	IN
cord-001293-dfaxj3bv	229	38	leukotrienes	leukotriene	NNS
cord-001293-dfaxj3bv	229	39	in	in	IN
cord-001293-dfaxj3bv	229	40	local	local	JJ
cord-001293-dfaxj3bv	229	41	innate	innate	JJ
cord-001293-dfaxj3bv	229	42	immune	immune	NN
cord-001293-dfaxj3bv	229	43	versus	versus	IN
cord-001293-dfaxj3bv	229	44	vascular	vascular	JJ
cord-001293-dfaxj3bv	229	45	responses	response	NNS
cord-001293-dfaxj3bv	229	46	in	in	IN
cord-001293-dfaxj3bv	229	47	a	a	DT
cord-001293-dfaxj3bv	229	48	model	model	NN
cord-001293-dfaxj3bv	229	49	of	of	IN
cord-001293-dfaxj3bv	229	50	sepsis	sepsis	NN
cord-001293-dfaxj3bv	230	1	Cytokines	cytokine	NNS
cord-001293-dfaxj3bv	230	2	induce	induce	VBP
cord-001293-dfaxj3bv	230	3	small	small	JJ
cord-001293-dfaxj3bv	230	4	intestine	intestine	NN
cord-001293-dfaxj3bv	230	5	and	and	CC
cord-001293-dfaxj3bv	230	6	liver	liver	NN
cord-001293-dfaxj3bv	230	7	injury	injury	NN
cord-001293-dfaxj3bv	230	8	after	after	IN
cord-001293-dfaxj3bv	230	9	renal	renal	JJ
cord-001293-dfaxj3bv	230	10	ischemia	ischemia	NN
cord-001293-dfaxj3bv	230	11	or	or	CC
cord-001293-dfaxj3bv	230	12	nephrectomy	nephrectomy	NN
cord-001293-dfaxj3bv	230	13	Critical	critical	JJ
cord-001293-dfaxj3bv	230	14	role	role	NN
cord-001293-dfaxj3bv	230	15	of	of	IN
cord-001293-dfaxj3bv	230	16	interleukin-17A	interleukin-17A	NNP
cord-001293-dfaxj3bv	230	17	in	in	IN
cord-001293-dfaxj3bv	230	18	murine	murine	JJ
cord-001293-dfaxj3bv	230	19	intestinal	intestinal	JJ
cord-001293-dfaxj3bv	230	20	ischemia	ischemia	NN
cord-001293-dfaxj3bv	230	21	-	-	HYPH
cord-001293-dfaxj3bv	230	22	reperfusion	reperfusion	NN
cord-001293-dfaxj3bv	230	23	injury	injury	NN
cord-001293-dfaxj3bv	230	24	Sepsis	sepsis	NN
cord-001293-dfaxj3bv	230	25	:	:	:
cord-001293-dfaxj3bv	231	1	a	a	DT
cord-001293-dfaxj3bv	231	2	new	new	JJ
cord-001293-dfaxj3bv	231	3	hypothesis	hypothesis	NN
cord-001293-dfaxj3bv	231	4	for	for	IN
cord-001293-dfaxj3bv	231	5	pathogenesis	pathogenesis	NN
cord-001293-dfaxj3bv	231	6	of	of	IN
cord-001293-dfaxj3bv	231	7	the	the	DT
cord-001293-dfaxj3bv	231	8	disease	disease	NN
cord-001293-dfaxj3bv	231	9	process	process	NN
cord-001293-dfaxj3bv	231	10	Immunodepression	Immunodepression	NNP
cord-001293-dfaxj3bv	231	11	in	in	IN
cord-001293-dfaxj3bv	231	12	sepsis	sepsis	NN
cord-001293-dfaxj3bv	231	13	and	and	CC
cord-001293-dfaxj3bv	231	14	SIRS	SIRS	NNP
cord-001293-dfaxj3bv	231	15	assessed	assess	VBN
cord-001293-dfaxj3bv	231	16	by	by	IN
cord-001293-dfaxj3bv	231	17	ex	ex	FW
cord-001293-dfaxj3bv	231	18	vivo	vivo	NN
cord-001293-dfaxj3bv	231	19	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	231	20	production	production	NN
cord-001293-dfaxj3bv	231	21	is	be	VBZ
cord-001293-dfaxj3bv	231	22	not	not	RB
cord-001293-dfaxj3bv	231	23	a	a	DT
cord-001293-dfaxj3bv	231	24	generalized	generalized	JJ
cord-001293-dfaxj3bv	231	25	phenomenon	phenomenon	NN
cord-001293-dfaxj3bv	231	26	:	:	:
cord-001293-dfaxj3bv	231	27	a	a	DT
cord-001293-dfaxj3bv	231	28	review	review	NN
cord-001293-dfaxj3bv	231	29	Pro	Pro	NNP
cord-001293-dfaxj3bv	231	30	-	-	:
cord-001293-dfaxj3bv	231	31	and	and	CC
cord-001293-dfaxj3bv	231	32	anti	anti	JJ
cord-001293-dfaxj3bv	231	33	-	-	JJ
cord-001293-dfaxj3bv	231	34	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	231	35	responses	response	NNS
cord-001293-dfaxj3bv	231	36	are	be	VBP
cord-001293-dfaxj3bv	231	37	regulated	regulate	VBN
cord-001293-dfaxj3bv	231	38	simultaneously	simultaneously	RB
cord-001293-dfaxj3bv	231	39	from	from	IN
cord-001293-dfaxj3bv	231	40	the	the	DT
cord-001293-dfaxj3bv	231	41	first	first	JJ
cord-001293-dfaxj3bv	231	42	moments	moment	NNS
cord-001293-dfaxj3bv	231	43	of	of	IN
cord-001293-dfaxj3bv	231	44	septic	septic	JJ
cord-001293-dfaxj3bv	231	45	shock	shock	NN
cord-001293-dfaxj3bv	231	46	Genome	genome	NN
cord-001293-dfaxj3bv	231	47	-	-	HYPH
cord-001293-dfaxj3bv	231	48	wide	wide	JJ
cord-001293-dfaxj3bv	231	49	transcription	transcription	NN
cord-001293-dfaxj3bv	231	50	profiling	profiling	NN
cord-001293-dfaxj3bv	231	51	of	of	IN
cord-001293-dfaxj3bv	231	52	human	human	JJ
cord-001293-dfaxj3bv	231	53	sepsis	sepsis	NN
cord-001293-dfaxj3bv	231	54	:	:	:
cord-001293-dfaxj3bv	231	55	a	a	DT
cord-001293-dfaxj3bv	231	56	systematic	systematic	JJ
cord-001293-dfaxj3bv	231	57	review	review	NN
cord-001293-dfaxj3bv	231	58	Dysregulation	Dysregulation	NNP
cord-001293-dfaxj3bv	231	59	of	of	IN
cord-001293-dfaxj3bv	231	60	in	in	FW
cord-001293-dfaxj3bv	231	61	vitro	vitro	FW
cord-001293-dfaxj3bv	231	62	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	231	63	production	production	NN
cord-001293-dfaxj3bv	231	64	by	by	IN
cord-001293-dfaxj3bv	231	65	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	231	66	during	during	IN
cord-001293-dfaxj3bv	231	67	sepsis	sepsis	NN
cord-001293-dfaxj3bv	232	1	Adib	Adib	NNP
cord-001293-dfaxj3bv	233	1	-Conquy	-conquy	IN
cord-001293-dfaxj3bv	233	2	M	M	NNP
cord-001293-dfaxj3bv	233	3	:	:	:
cord-001293-dfaxj3bv	233	4	Differential	differential	JJ
cord-001293-dfaxj3bv	233	5	down	down	JJ
cord-001293-dfaxj3bv	233	6	-	-	HYPH
cord-001293-dfaxj3bv	233	7	regulation	regulation	NN
cord-001293-dfaxj3bv	233	8	of	of	IN
cord-001293-dfaxj3bv	233	9	HLA	HLA	NNP
cord-001293-dfaxj3bv	233	10	-	-	HYPH
cord-001293-dfaxj3bv	233	11	DR	DR	NNP
cord-001293-dfaxj3bv	233	12	on	on	IN
cord-001293-dfaxj3bv	233	13	monocyte	monocyte	NNP
cord-001293-dfaxj3bv	233	14	subpopulations	subpopulation	NNS
cord-001293-dfaxj3bv	233	15	during	during	IN
cord-001293-dfaxj3bv	233	16	systemic	systemic	JJ
cord-001293-dfaxj3bv	233	17	inflammation	inflammation	NN
cord-001293-dfaxj3bv	233	18	Immune	immune	JJ
cord-001293-dfaxj3bv	233	19	paralysis	paralysis	NN
cord-001293-dfaxj3bv	233	20	in	in	IN
cord-001293-dfaxj3bv	233	21	trauma	trauma	NN
cord-001293-dfaxj3bv	233	22	patients	patient	NNS
cord-001293-dfaxj3bv	233	23	,	,	,
cord-001293-dfaxj3bv	233	24	implications	implication	NNS
cord-001293-dfaxj3bv	233	25	for	for	IN
cord-001293-dfaxj3bv	233	26	pre	pre	JJ
cord-001293-dfaxj3bv	233	27	-	-	JJ
cord-001293-dfaxj3bv	233	28	hospital	hospital	JJ
cord-001293-dfaxj3bv	233	29	intervention	intervention	NN
cord-001293-dfaxj3bv	233	30	Successful	successful	JJ
cord-001293-dfaxj3bv	233	31	cardiopulmonary	cardiopulmonary	JJ
cord-001293-dfaxj3bv	233	32	resuscitation	resuscitation	NN
cord-001293-dfaxj3bv	233	33	after	after	IN
cord-001293-dfaxj3bv	233	34	cardiac	cardiac	JJ
cord-001293-dfaxj3bv	233	35	arrest	arrest	NN
cord-001293-dfaxj3bv	233	36	as	as	IN
cord-001293-dfaxj3bv	233	37	a	a	DT
cord-001293-dfaxj3bv	233	38	'	'	``
cord-001293-dfaxj3bv	233	39	sepsis	sepsis	NN
cord-001293-dfaxj3bv	233	40	like	like	IN
cord-001293-dfaxj3bv	233	41	'	'	''
cord-001293-dfaxj3bv	233	42	syndrome	syndrome	NN
cord-001293-dfaxj3bv	234	1	Persistent	persistent	JJ
cord-001293-dfaxj3bv	234	2	inflammation	inflammation	NN
cord-001293-dfaxj3bv	234	3	and	and	CC
cord-001293-dfaxj3bv	234	4	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	234	5	:	:	:
cord-001293-dfaxj3bv	234	6	a	a	DT
cord-001293-dfaxj3bv	234	7	common	common	JJ
cord-001293-dfaxj3bv	234	8	syndrome	syndrome	NN
cord-001293-dfaxj3bv	234	9	and	and	CC
cord-001293-dfaxj3bv	234	10	new	new	JJ
cord-001293-dfaxj3bv	234	11	horizon	horizon	NN
cord-001293-dfaxj3bv	234	12	for	for	IN
cord-001293-dfaxj3bv	234	13	surgical	surgical	JJ
cord-001293-dfaxj3bv	234	14	intensive	intensive	JJ
cord-001293-dfaxj3bv	234	15	care	care	NN
cord-001293-dfaxj3bv	234	16	Prognostic	prognostic	JJ
cord-001293-dfaxj3bv	234	17	value	value	NN
cord-001293-dfaxj3bv	234	18	of	of	IN
cord-001293-dfaxj3bv	234	19	phagocytic	phagocytic	JJ
cord-001293-dfaxj3bv	234	20	activity	activity	NN
cord-001293-dfaxj3bv	234	21	of	of	IN
cord-001293-dfaxj3bv	234	22	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	234	23	and	and	CC
cord-001293-dfaxj3bv	234	24	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	234	25	in	in	IN
cord-001293-dfaxj3bv	234	26	sepsis	sepsis	NN
cord-001293-dfaxj3bv	234	27	.	.	.
cord-001293-dfaxj3bv	235	1	Correlation	correlation	NN
cord-001293-dfaxj3bv	235	2	to	to	IN
cord-001293-dfaxj3bv	235	3	CD64	CD64	NNP
cord-001293-dfaxj3bv	235	4	and	and	CC
cord-001293-dfaxj3bv	235	5	CD14	CD14	NNP
cord-001293-dfaxj3bv	235	6	antigen	antigen	NN
cord-001293-dfaxj3bv	235	7	expression	expression	NN
cord-001293-dfaxj3bv	235	8	Upregulation	Upregulation	NNP
cord-001293-dfaxj3bv	235	9	of	of	IN
cord-001293-dfaxj3bv	235	10	MyD88s	MyD88s	NNP
cord-001293-dfaxj3bv	235	11	and	and	CC
cord-001293-dfaxj3bv	235	12	SIGIRR	SIGIRR	NNP
cord-001293-dfaxj3bv	235	13	,	,	,
cord-001293-dfaxj3bv	235	14	molecules	molecule	NNS
cord-001293-dfaxj3bv	235	15	inhibiting	inhibit	VBG
cord-001293-dfaxj3bv	235	16	Toll	Toll	NNP
cord-001293-dfaxj3bv	235	17	-	-	HYPH
cord-001293-dfaxj3bv	235	18	like	like	JJ
cord-001293-dfaxj3bv	235	19	receptor	receptor	NN
cord-001293-dfaxj3bv	235	20	signaling	signaling	NN
cord-001293-dfaxj3bv	235	21	,	,	,
cord-001293-dfaxj3bv	235	22	in	in	IN
cord-001293-dfaxj3bv	235	23	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	235	24	from	from	IN
cord-001293-dfaxj3bv	235	25	septic	septic	JJ
cord-001293-dfaxj3bv	235	26	patients	patient	NNS
cord-001293-dfaxj3bv	235	27	Staphylococcus	Staphylococcus	NNP
cord-001293-dfaxj3bv	235	28	aureus	aureus	NN
cord-001293-dfaxj3bv	235	29	and	and	CC
cord-001293-dfaxj3bv	235	30	lipopolysaccharide	lipopolysaccharide	NN
cord-001293-dfaxj3bv	235	31	induce	induce	VBP
cord-001293-dfaxj3bv	235	32	homologous	homologous	JJ
cord-001293-dfaxj3bv	235	33	tolerance	tolerance	NN
cord-001293-dfaxj3bv	235	34	but	but	CC
cord-001293-dfaxj3bv	235	35	heterologous	heterologous	JJ
cord-001293-dfaxj3bv	235	36	priming	priming	NN
cord-001293-dfaxj3bv	235	37	:	:	:
cord-001293-dfaxj3bv	235	38	role	role	NN
cord-001293-dfaxj3bv	235	39	of	of	IN
cord-001293-dfaxj3bv	235	40	interferon	interferon	NN
cord-001293-dfaxj3bv	235	41	-	-	HYPH
cord-001293-dfaxj3bv	235	42	gamma	gamma	NN
cord-001293-dfaxj3bv	235	43	Candida	Candida	NNP
cord-001293-dfaxj3bv	235	44	albicans	albican	NNS
cord-001293-dfaxj3bv	235	45	infection	infection	NN
cord-001293-dfaxj3bv	235	46	affords	afford	VBZ
cord-001293-dfaxj3bv	235	47	protection	protection	NN
cord-001293-dfaxj3bv	235	48	against	against	IN
cord-001293-dfaxj3bv	235	49	reinfection	reinfection	NN
cord-001293-dfaxj3bv	235	50	via	via	IN
cord-001293-dfaxj3bv	235	51	functional	functional	JJ
cord-001293-dfaxj3bv	235	52	reprogramming	reprogramming	NN
cord-001293-dfaxj3bv	235	53	of	of	IN
cord-001293-dfaxj3bv	235	54	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	235	55	Reprogramming	reprogramming	NN
cord-001293-dfaxj3bv	235	56	of	of	IN
cord-001293-dfaxj3bv	235	57	circulatory	circulatory	JJ
cord-001293-dfaxj3bv	235	58	cells	cell	NNS
cord-001293-dfaxj3bv	235	59	in	in	IN
cord-001293-dfaxj3bv	235	60	sepsis	sepsis	NN
cord-001293-dfaxj3bv	235	61	and	and	CC
cord-001293-dfaxj3bv	235	62	SIRS	SIRS	NNP
cord-001293-dfaxj3bv	235	63	Androstenediol	Androstenediol	NNP
cord-001293-dfaxj3bv	235	64	ameliorates	ameliorate	VBZ
cord-001293-dfaxj3bv	235	65	alterations	alteration	NNS
cord-001293-dfaxj3bv	235	66	in	in	IN
cord-001293-dfaxj3bv	235	67	immune	immune	JJ
cord-001293-dfaxj3bv	235	68	cells	cell	NNS
cord-001293-dfaxj3bv	235	69	cytokine	cytokine	NN
cord-001293-dfaxj3bv	235	70	production	production	NN
cord-001293-dfaxj3bv	235	71	capacity	capacity	NN
cord-001293-dfaxj3bv	235	72	in	in	IN
cord-001293-dfaxj3bv	235	73	a	a	DT
cord-001293-dfaxj3bv	235	74	two	two	CD
cord-001293-dfaxj3bv	235	75	-	-	HYPH
cord-001293-dfaxj3bv	235	76	hit	hit	VBN
cord-001293-dfaxj3bv	235	77	model	model	NN
cord-001293-dfaxj3bv	235	78	of	of	IN
cord-001293-dfaxj3bv	235	79	trauma	trauma	NN
cord-001293-dfaxj3bv	235	80	-	-	HYPH
cord-001293-dfaxj3bv	235	81	hemorrhage	hemorrhage	NN
cord-001293-dfaxj3bv	235	82	and	and	CC
cord-001293-dfaxj3bv	235	83	sepsis	sepsis	NN
cord-001293-dfaxj3bv	235	84	Cytokine	cytokine	NN
cord-001293-dfaxj3bv	235	85	productive	productive	JJ
cord-001293-dfaxj3bv	235	86	capacity	capacity	NN
cord-001293-dfaxj3bv	235	87	of	of	IN
cord-001293-dfaxj3bv	235	88	alveolar	alveolar	JJ
cord-001293-dfaxj3bv	235	89	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	235	90	and	and	CC
cord-001293-dfaxj3bv	235	91	Kupffer	Kupffer	NNP
cord-001293-dfaxj3bv	235	92	cells	cell	NNS
cord-001293-dfaxj3bv	235	93	after	after	IN
cord-001293-dfaxj3bv	235	94	femoral	femoral	JJ
cord-001293-dfaxj3bv	235	95	fracture	fracture	NN
cord-001293-dfaxj3bv	235	96	and	and	CC
cord-001293-dfaxj3bv	235	97	blunt	blunt	VB
cord-001293-dfaxj3bv	235	98	chest	chest	NN
cord-001293-dfaxj3bv	235	99	trauma	trauma	NN
cord-001293-dfaxj3bv	235	100	in	in	IN
cord-001293-dfaxj3bv	235	101	a	a	DT
cord-001293-dfaxj3bv	235	102	murine	murine	JJ
cord-001293-dfaxj3bv	235	103	trauma	trauma	NN
cord-001293-dfaxj3bv	235	104	model	model	NN
cord-001293-dfaxj3bv	235	105	Lung	lung	NN
cord-001293-dfaxj3bv	235	106	microenvironment	microenvironment	NN
cord-001293-dfaxj3bv	235	107	contributes	contribute	VBZ
cord-001293-dfaxj3bv	235	108	to	to	IN
cord-001293-dfaxj3bv	235	109	the	the	DT
cord-001293-dfaxj3bv	235	110	resistance	resistance	NN
cord-001293-dfaxj3bv	235	111	of	of	IN
cord-001293-dfaxj3bv	235	112	alveolar	alveolar	JJ
cord-001293-dfaxj3bv	235	113	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	235	114	to	to	TO
cord-001293-dfaxj3bv	235	115	develop	develop	VB
cord-001293-dfaxj3bv	235	116	tolerance	tolerance	NN
cord-001293-dfaxj3bv	235	117	to	to	IN
cord-001293-dfaxj3bv	235	118	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	236	1	*	*	NFP
cord-001293-dfaxj3bv	236	2	Priming	priming	NN
cord-001293-dfaxj3bv	236	3	of	of	IN
cord-001293-dfaxj3bv	236	4	alveolar	alveolar	JJ
cord-001293-dfaxj3bv	236	5	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	236	6	upon	upon	IN
cord-001293-dfaxj3bv	236	7	instillation	instillation	NN
cord-001293-dfaxj3bv	236	8	of	of	IN
cord-001293-dfaxj3bv	236	9	lipopolysaccharide	lipopolysaccharide	NN
cord-001293-dfaxj3bv	236	10	in	in	IN
cord-001293-dfaxj3bv	236	11	the	the	DT
cord-001293-dfaxj3bv	236	12	human	human	JJ
cord-001293-dfaxj3bv	236	13	lung	lung	NN
cord-001293-dfaxj3bv	236	14	Endotoxin	Endotoxin	NNP
cord-001293-dfaxj3bv	236	15	tolerance	tolerance	NN
cord-001293-dfaxj3bv	236	16	'	'	''
cord-001293-dfaxj3bv	236	17	:	:	:
cord-001293-dfaxj3bv	236	18	TNF	tnf	NN
cord-001293-dfaxj3bv	236	19	-	-	HYPH
cord-001293-dfaxj3bv	236	20	alpha	alpha	NN
cord-001293-dfaxj3bv	236	21	hyper	hyper	NN
cord-001293-dfaxj3bv	236	22	-	-	NN
cord-001293-dfaxj3bv	236	23	reactivity	reactivity	JJ
cord-001293-dfaxj3bv	236	24	and	and	CC
cord-001293-dfaxj3bv	236	25	tubular	tubular	JJ
cord-001293-dfaxj3bv	236	26	cytoresistance	cytoresistance	NN
cord-001293-dfaxj3bv	236	27	in	in	IN
cord-001293-dfaxj3bv	236	28	a	a	DT
cord-001293-dfaxj3bv	236	29	renal	renal	JJ
cord-001293-dfaxj3bv	236	30	cholesterol	cholesterol	NN
cord-001293-dfaxj3bv	236	31	loading	loading	NN
cord-001293-dfaxj3bv	236	32	state	state	NN
cord-001293-dfaxj3bv	236	33	Reduction	Reduction	NNP
cord-001293-dfaxj3bv	236	34	of	of	IN
cord-001293-dfaxj3bv	236	35	risk	risk	NN
cord-001293-dfaxj3bv	236	36	following	follow	VBG
cord-001293-dfaxj3bv	236	37	endotoxin	endotoxin	NN
cord-001293-dfaxj3bv	236	38	injection	injection	NN
cord-001293-dfaxj3bv	236	39	in	in	IN
cord-001293-dfaxj3bv	236	40	unilaterally	unilaterally	RB
cord-001293-dfaxj3bv	236	41	nephrectomized	nephrectomized	JJ
cord-001293-dfaxj3bv	236	42	rats	rat	NNS
cord-001293-dfaxj3bv	236	43	Delineation	delineation	NN
cord-001293-dfaxj3bv	236	44	of	of	IN
cord-001293-dfaxj3bv	236	45	diverse	diverse	JJ
cord-001293-dfaxj3bv	236	46	macrophage	macrophage	NN
cord-001293-dfaxj3bv	236	47	activation	activation	NN
cord-001293-dfaxj3bv	236	48	programs	program	NNS
cord-001293-dfaxj3bv	236	49	in	in	IN
cord-001293-dfaxj3bv	236	50	response	response	NN
cord-001293-dfaxj3bv	236	51	to	to	IN
cord-001293-dfaxj3bv	236	52	intracellular	intracellular	JJ
cord-001293-dfaxj3bv	236	53	parasites	parasite	NNS
cord-001293-dfaxj3bv	236	54	and	and	CC
cord-001293-dfaxj3bv	236	55	cytokines	cytokine	NNS
cord-001293-dfaxj3bv	236	56	Complementary	complementary	JJ
cord-001293-dfaxj3bv	236	57	organ	organ	NN
cord-001293-dfaxj3bv	236	58	expression	expression	NN
cord-001293-dfaxj3bv	236	59	of	of	IN
cord-001293-dfaxj3bv	236	60	IL-1	IL-1	NNP
cord-001293-dfaxj3bv	236	61	vs	vs	IN
cord-001293-dfaxj3bv	236	62	IL-6	IL-6	NNP
cord-001293-dfaxj3bv	236	63	and	and	CC
cord-001293-dfaxj3bv	236	64	CSF-1	CSF-1	NNP
cord-001293-dfaxj3bv	236	65	activities	activity	NNS
cord-001293-dfaxj3bv	236	66	in	in	IN
cord-001293-dfaxj3bv	236	67	normal	normal	JJ
cord-001293-dfaxj3bv	236	68	and	and	CC
cord-001293-dfaxj3bv	236	69	LPS	lp	NNS
cord-001293-dfaxj3bv	236	70	injected	inject	VBD
cord-001293-dfaxj3bv	236	71	mice	mouse	NNS
cord-001293-dfaxj3bv	237	1	Hemophagocytic	hemophagocytic	JJ
cord-001293-dfaxj3bv	237	2	lymphohistiocytosis	lymphohistiocytosis	NN
cord-001293-dfaxj3bv	237	3	:	:	:
cord-001293-dfaxj3bv	237	4	a	a	DT
cord-001293-dfaxj3bv	237	5	potentially	potentially	RB
cord-001293-dfaxj3bv	237	6	underrecognized	underrecognize	VBN
cord-001293-dfaxj3bv	237	7	association	association	NN
cord-001293-dfaxj3bv	237	8	with	with	IN
cord-001293-dfaxj3bv	237	9	systemic	systemic	JJ
cord-001293-dfaxj3bv	237	10	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	237	11	response	response	NN
cord-001293-dfaxj3bv	237	12	syndrome	syndrome	NN
cord-001293-dfaxj3bv	237	13	,	,	,
cord-001293-dfaxj3bv	237	14	severe	severe	JJ
cord-001293-dfaxj3bv	237	15	sepsis	sepsis	NN
cord-001293-dfaxj3bv	237	16	,	,	,
cord-001293-dfaxj3bv	237	17	and	and	CC
cord-001293-dfaxj3bv	237	18	septic	septic	JJ
cord-001293-dfaxj3bv	237	19	shock	shock	NN
cord-001293-dfaxj3bv	237	20	in	in	IN
cord-001293-dfaxj3bv	237	21	adults	adult	NNS
cord-001293-dfaxj3bv	238	1	Polymicrobial	polymicrobial	JJ
cord-001293-dfaxj3bv	238	2	sepsis	sepsis	NN
cord-001293-dfaxj3bv	238	3	induces	induce	VBZ
cord-001293-dfaxj3bv	238	4	divergent	divergent	JJ
cord-001293-dfaxj3bv	238	5	effects	effect	NNS
cord-001293-dfaxj3bv	238	6	on	on	IN
cord-001293-dfaxj3bv	238	7	splenic	splenic	JJ
cord-001293-dfaxj3bv	238	8	and	and	CC
cord-001293-dfaxj3bv	238	9	peritoneal	peritoneal	JJ
cord-001293-dfaxj3bv	238	10	dendritic	dendritic	JJ
cord-001293-dfaxj3bv	238	11	cell	cell	NN
cord-001293-dfaxj3bv	238	12	function	function	NN
cord-001293-dfaxj3bv	238	13	in	in	IN
cord-001293-dfaxj3bv	238	14	mice	mouse	NNS
cord-001293-dfaxj3bv	238	15	Differing	differ	VBG
cord-001293-dfaxj3bv	238	16	effects	effect	NNS
cord-001293-dfaxj3bv	238	17	of	of	IN
cord-001293-dfaxj3bv	238	18	interleukin-10	interleukin-10	NN
cord-001293-dfaxj3bv	238	19	on	on	IN
cord-001293-dfaxj3bv	238	20	cutaneous	cutaneous	JJ
cord-001293-dfaxj3bv	238	21	and	and	CC
cord-001293-dfaxj3bv	238	22	pulmonary	pulmonary	NNP
cord-001293-dfaxj3bv	238	23	Francisella	Francisella	NNP
cord-001293-dfaxj3bv	238	24	tularensis	tularensis	NNP
cord-001293-dfaxj3bv	238	25	live	live	JJ
cord-001293-dfaxj3bv	238	26	vaccine	vaccine	NN
cord-001293-dfaxj3bv	238	27	strain	strain	NN
cord-001293-dfaxj3bv	238	28	infection	infection	NN
cord-001293-dfaxj3bv	238	29	Adib	Adib	NNP
cord-001293-dfaxj3bv	238	30	-	-	HYPH
cord-001293-dfaxj3bv	238	31	Conquy	Conquy	NNP
cord-001293-dfaxj3bv	238	32	M	M	NNP
cord-001293-dfaxj3bv	238	33	:	:	:
cord-001293-dfaxj3bv	238	34	Protective	protective	JJ
cord-001293-dfaxj3bv	238	35	or	or	CC
cord-001293-dfaxj3bv	238	36	deleterious	deleterious	JJ
cord-001293-dfaxj3bv	238	37	role	role	NN
cord-001293-dfaxj3bv	238	38	of	of	IN
cord-001293-dfaxj3bv	238	39	scavenger	scavenger	NN
cord-001293-dfaxj3bv	238	40	receptors	receptor	NNS
cord-001293-dfaxj3bv	238	41	SR	SR	NNP
cord-001293-dfaxj3bv	238	42	-	-	HYPH
cord-001293-dfaxj3bv	238	43	A	A	NNP
cord-001293-dfaxj3bv	238	44	and	and	CC
cord-001293-dfaxj3bv	238	45	CD36	CD36	NNP
cord-001293-dfaxj3bv	238	46	on	on	IN
cord-001293-dfaxj3bv	238	47	host	host	NN
cord-001293-dfaxj3bv	238	48	resistance	resistance	NN
cord-001293-dfaxj3bv	238	49	to	to	IN
cord-001293-dfaxj3bv	238	50	Staphylococcus	Staphylococcus	NNP
cord-001293-dfaxj3bv	238	51	aureus	aureus	NN
cord-001293-dfaxj3bv	238	52	depends	depend	VBZ
cord-001293-dfaxj3bv	238	53	on	on	IN
cord-001293-dfaxj3bv	238	54	the	the	DT
cord-001293-dfaxj3bv	238	55	site	site	NN
cord-001293-dfaxj3bv	238	56	of	of	IN
cord-001293-dfaxj3bv	238	57	infection	infection	NN
cord-001293-dfaxj3bv	238	58	MARCO	MARCO	NNP
cord-001293-dfaxj3bv	238	59	is	be	VBZ
cord-001293-dfaxj3bv	238	60	required	require	VBN
cord-001293-dfaxj3bv	238	61	for	for	IN
cord-001293-dfaxj3bv	238	62	TLR2-and	tlr2-and	JJ
cord-001293-dfaxj3bv	238	63	Nod2-mediated	nod2-mediated	JJ
cord-001293-dfaxj3bv	238	64	responses	response	NNS
cord-001293-dfaxj3bv	238	65	to	to	IN
cord-001293-dfaxj3bv	238	66	Streptococcus	streptococcus	NN
cord-001293-dfaxj3bv	238	67	pneumoniae	pneumoniae	NN
cord-001293-dfaxj3bv	238	68	and	and	CC
cord-001293-dfaxj3bv	238	69	clearance	clearance	NN
cord-001293-dfaxj3bv	238	70	of	of	IN
cord-001293-dfaxj3bv	238	71	pneumococcal	pneumococcal	JJ
cord-001293-dfaxj3bv	238	72	colonization	colonization	NN
cord-001293-dfaxj3bv	238	73	in	in	IN
cord-001293-dfaxj3bv	238	74	the	the	DT
cord-001293-dfaxj3bv	238	75	murine	murine	JJ
cord-001293-dfaxj3bv	238	76	nasopharynx	nasopharynx	NN
cord-001293-dfaxj3bv	238	77	Autocrine	Autocrine	NNP
cord-001293-dfaxj3bv	238	78	modulation	modulation	NN
cord-001293-dfaxj3bv	238	79	of	of	IN
cord-001293-dfaxj3bv	238	80	IL-8	il-8	NN
cord-001293-dfaxj3bv	238	81	production	production	NN
cord-001293-dfaxj3bv	238	82	by	by	IN
cord-001293-dfaxj3bv	238	83	sputum	sputum	JJ
cord-001293-dfaxj3bv	238	84	neutrophils	neutrophil	NNS
cord-001293-dfaxj3bv	238	85	in	in	IN
cord-001293-dfaxj3bv	238	86	chronic	chronic	JJ
cord-001293-dfaxj3bv	238	87	bronchial	bronchial	JJ
cord-001293-dfaxj3bv	238	88	sepsis	sepsis	NN
cord-001293-dfaxj3bv	238	89	Characterization	characterization	NN
cord-001293-dfaxj3bv	238	90	and	and	CC
cord-001293-dfaxj3bv	238	91	modulation	modulation	NN
cord-001293-dfaxj3bv	238	92	of	of	IN
cord-001293-dfaxj3bv	238	93	the	the	DT
cord-001293-dfaxj3bv	238	94	immunosuppressive	immunosuppressive	JJ
cord-001293-dfaxj3bv	238	95	phase	phase	NN
cord-001293-dfaxj3bv	238	96	of	of	IN
cord-001293-dfaxj3bv	238	97	sepsis	sepsis	NN
cord-001293-dfaxj3bv	238	98	Resilience	resilience	NN
cord-001293-dfaxj3bv	238	99	to	to	IN
cord-001293-dfaxj3bv	238	100	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	238	101	infection	infection	NN
cord-001293-dfaxj3bv	238	102	:	:	:
cord-001293-dfaxj3bv	238	103	difference	difference	NN
cord-001293-dfaxj3bv	238	104	between	between	IN
cord-001293-dfaxj3bv	238	105	species	specie	NNS
cord-001293-dfaxj3bv	238	106	could	could	MD
cord-001293-dfaxj3bv	238	107	be	be	VB
cord-001293-dfaxj3bv	238	108	due	due	JJ
cord-001293-dfaxj3bv	238	109	to	to	IN
cord-001293-dfaxj3bv	238	110	proteins	protein	NNS
cord-001293-dfaxj3bv	238	111	in	in	IN
cord-001293-dfaxj3bv	238	112	serum	serum	NN
cord-001293-dfaxj3bv	238	113	Genomic	genomic	JJ
cord-001293-dfaxj3bv	238	114	responses	response	NNS
cord-001293-dfaxj3bv	238	115	in	in	IN
cord-001293-dfaxj3bv	238	116	mouse	mouse	NN
cord-001293-dfaxj3bv	238	117	models	model	NNS
cord-001293-dfaxj3bv	238	118	poorly	poorly	RB
cord-001293-dfaxj3bv	238	119	mimic	mimic	VBP
cord-001293-dfaxj3bv	238	120	human	human	JJ
cord-001293-dfaxj3bv	238	121	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	238	122	diseases	disease	NNS
cord-001293-dfaxj3bv	238	123	Pig	pig	NN
cord-001293-dfaxj3bv	238	124	bone	bone	NN
cord-001293-dfaxj3bv	238	125	marrow	marrow	NN
cord-001293-dfaxj3bv	238	126	-	-	HYPH
cord-001293-dfaxj3bv	238	127	derived	derive	VBN
cord-001293-dfaxj3bv	238	128	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	238	129	resemble	resemble	VBP
cord-001293-dfaxj3bv	238	130	human	human	JJ
cord-001293-dfaxj3bv	238	131	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	238	132	in	in	IN
cord-001293-dfaxj3bv	238	133	their	-PRON-	PRP$
cord-001293-dfaxj3bv	238	134	response	response	NN
cord-001293-dfaxj3bv	238	135	to	to	IN
cord-001293-dfaxj3bv	238	136	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	238	137	lipopolysaccharide	lipopolysaccharide	NN
cord-001293-dfaxj3bv	238	138	Influence	influence	NN
cord-001293-dfaxj3bv	238	139	of	of	IN
cord-001293-dfaxj3bv	238	140	systemic	systemic	JJ
cord-001293-dfaxj3bv	238	141	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	238	142	response	response	NN
cord-001293-dfaxj3bv	238	143	syndrome	syndrome	NN
cord-001293-dfaxj3bv	238	144	on	on	IN
cord-001293-dfaxj3bv	238	145	host	host	NN
cord-001293-dfaxj3bv	238	146	resistance	resistance	NN
cord-001293-dfaxj3bv	238	147	against	against	IN
cord-001293-dfaxj3bv	238	148	bacterial	bacterial	JJ
cord-001293-dfaxj3bv	238	149	infections	infection	NNS
cord-001293-dfaxj3bv	239	1	The	the	DT
cord-001293-dfaxj3bv	239	2	late	late	JJ
cord-001293-dfaxj3bv	239	3	phase	phase	NN
cord-001293-dfaxj3bv	239	4	of	of	IN
cord-001293-dfaxj3bv	239	5	sepsis	sepsis	NN
cord-001293-dfaxj3bv	239	6	is	be	VBZ
cord-001293-dfaxj3bv	239	7	characterized	characterize	VBN
cord-001293-dfaxj3bv	239	8	by	by	IN
cord-001293-dfaxj3bv	239	9	an	an	DT
cord-001293-dfaxj3bv	239	10	increased	increase	VBN
cord-001293-dfaxj3bv	239	11	microbiological	microbiological	JJ
cord-001293-dfaxj3bv	239	12	burden	burden	NN
cord-001293-dfaxj3bv	239	13	and	and	CC
cord-001293-dfaxj3bv	239	14	death	death	NN
cord-001293-dfaxj3bv	239	15	rate	rate	NN
cord-001293-dfaxj3bv	239	16	Cytomegalovirus	Cytomegalovirus	NNP
cord-001293-dfaxj3bv	239	17	infection	infection	NN
cord-001293-dfaxj3bv	239	18	in	in	IN
cord-001293-dfaxj3bv	239	19	critically	critically	RB
cord-001293-dfaxj3bv	239	20	ill	ill	JJ
cord-001293-dfaxj3bv	239	21	patients	patient	NNS
cord-001293-dfaxj3bv	239	22	:	:	:
cord-001293-dfaxj3bv	239	23	a	a	DT
cord-001293-dfaxj3bv	239	24	systematic	systematic	JJ
cord-001293-dfaxj3bv	239	25	review	review	NN
cord-001293-dfaxj3bv	239	26	Herpes	Herpes	NNP
cord-001293-dfaxj3bv	239	27	simplex	simplex	NN
cord-001293-dfaxj3bv	239	28	virus	virus	NN
cord-001293-dfaxj3bv	239	29	lung	lung	NN
cord-001293-dfaxj3bv	239	30	infection	infection	NN
cord-001293-dfaxj3bv	239	31	in	in	IN
cord-001293-dfaxj3bv	239	32	patients	patient	NNS
cord-001293-dfaxj3bv	239	33	undergoing	undergo	VBG
cord-001293-dfaxj3bv	239	34	prolonged	prolong	VBN
cord-001293-dfaxj3bv	239	35	mechanical	mechanical	JJ
cord-001293-dfaxj3bv	239	36	ventilation	ventilation	NN
cord-001293-dfaxj3bv	239	37	Macroscopic	macroscopic	JJ
cord-001293-dfaxj3bv	239	38	postmortem	postmortem	JJ
cord-001293-dfaxj3bv	239	39	findings	finding	NNS
cord-001293-dfaxj3bv	239	40	in	in	IN
cord-001293-dfaxj3bv	239	41	235	235	CD
cord-001293-dfaxj3bv	239	42	surgical	surgical	JJ
cord-001293-dfaxj3bv	239	43	intensive	intensive	JJ
cord-001293-dfaxj3bv	239	44	care	care	NN
cord-001293-dfaxj3bv	239	45	patients	patient	NNS
cord-001293-dfaxj3bv	239	46	with	with	IN
cord-001293-dfaxj3bv	239	47	sepsis	sepsis	NN
cord-001293-dfaxj3bv	239	48	Monocyte	Monocyte	NNP
cord-001293-dfaxj3bv	239	49	deactivation	deactivation	NN
cord-001293-dfaxj3bv	239	50	in	in	IN
cord-001293-dfaxj3bv	239	51	septic	septic	JJ
cord-001293-dfaxj3bv	239	52	patients	patient	NNS
cord-001293-dfaxj3bv	239	53	:	:	:
cord-001293-dfaxj3bv	239	54	restoration	restoration	NN
cord-001293-dfaxj3bv	239	55	by	by	IN
cord-001293-dfaxj3bv	239	56	IFNg	IFNg	NNP
cord-001293-dfaxj3bv	239	57	treatment	treatment	NN
cord-001293-dfaxj3bv	240	1	Interferon	interferon	NN
cord-001293-dfaxj3bv	240	2	-	-	HYPH
cord-001293-dfaxj3bv	240	3	gamma	gamma	NN
cord-001293-dfaxj3bv	240	4	in	in	IN
cord-001293-dfaxj3bv	240	5	the	the	DT
cord-001293-dfaxj3bv	240	6	prevention	prevention	NN
cord-001293-dfaxj3bv	240	7	of	of	IN
cord-001293-dfaxj3bv	240	8	severe	severe	JJ
cord-001293-dfaxj3bv	240	9	burn	burn	NN
cord-001293-dfaxj3bv	240	10	-	-	HYPH
cord-001293-dfaxj3bv	240	11	related	relate	VBN
cord-001293-dfaxj3bv	240	12	infections	infection	NNS
cord-001293-dfaxj3bv	240	13	:	:	:
cord-001293-dfaxj3bv	240	14	a	a	DT
cord-001293-dfaxj3bv	240	15	European	european	JJ
cord-001293-dfaxj3bv	240	16	phase	phase	NN
cord-001293-dfaxj3bv	240	17	III	iii	CD
cord-001293-dfaxj3bv	240	18	multicenter	multicenter	JJ
cord-001293-dfaxj3bv	240	19	trial	trial	NN
cord-001293-dfaxj3bv	240	20	.	.	.
cord-001293-dfaxj3bv	241	1	The	the	DT
cord-001293-dfaxj3bv	241	2	Severe	Severe	NNP
cord-001293-dfaxj3bv	241	3	Burns	Burns	NNP
cord-001293-dfaxj3bv	241	4	Study	Study	NNP
cord-001293-dfaxj3bv	241	5	Group	Group	NNP
cord-001293-dfaxj3bv	241	6	Granulocyte	Granulocyte	NNP
cord-001293-dfaxj3bv	241	7	-	-	HYPH
cord-001293-dfaxj3bv	241	8	colony	colony	NN
cord-001293-dfaxj3bv	241	9	stimulating	stimulating	NN
cord-001293-dfaxj3bv	241	10	factor	factor	NN
cord-001293-dfaxj3bv	241	11	(	(	-LRB-
cord-001293-dfaxj3bv	241	12	G	G	NNP
cord-001293-dfaxj3bv	241	13	-	-	HYPH
cord-001293-dfaxj3bv	241	14	CSF	CSF	NNP
cord-001293-dfaxj3bv	241	15	)	)	-RRB-
cord-001293-dfaxj3bv	241	16	and	and	CC
cord-001293-dfaxj3bv	241	17	granulocyte	granulocyte	NN
cord-001293-dfaxj3bv	241	18	-	-	HYPH
cord-001293-dfaxj3bv	241	19	macrophage	macrophage	NN
cord-001293-dfaxj3bv	241	20	colony	colony	NN
cord-001293-dfaxj3bv	241	21	stimulating	stimulate	VBG
cord-001293-dfaxj3bv	241	22	factor	factor	NN
cord-001293-dfaxj3bv	241	23	(	(	-LRB-
cord-001293-dfaxj3bv	241	24	GM	GM	NNP
cord-001293-dfaxj3bv	241	25	-	-	HYPH
cord-001293-dfaxj3bv	241	26	CSF	CSF	NNP
cord-001293-dfaxj3bv	241	27	)	)	-RRB-
cord-001293-dfaxj3bv	241	28	for	for	IN
cord-001293-dfaxj3bv	241	29	sepsis	sepsis	NN
cord-001293-dfaxj3bv	241	30	:	:	:
cord-001293-dfaxj3bv	241	31	a	a	DT
cord-001293-dfaxj3bv	241	32	meta	meta	JJ
cord-001293-dfaxj3bv	241	33	-	-	HYPH
cord-001293-dfaxj3bv	241	34	analysis	analysis	NN
cord-001293-dfaxj3bv	241	35	Treatment	treatment	NN
cord-001293-dfaxj3bv	241	36	with	with	IN
cord-001293-dfaxj3bv	241	37	granulocyte	granulocyte	NN
cord-001293-dfaxj3bv	241	38	-	-	HYPH
cord-001293-dfaxj3bv	241	39	macrophage	macrophage	NN
cord-001293-dfaxj3bv	241	40	colony	colony	NN
cord-001293-dfaxj3bv	241	41	stimulating	stimulate	VBG
cord-001293-dfaxj3bv	241	42	factor	factor	NN
cord-001293-dfaxj3bv	241	43	and	and	CC
cord-001293-dfaxj3bv	241	44	the	the	DT
cord-001293-dfaxj3bv	241	45	adult	adult	NN
cord-001293-dfaxj3bv	241	46	respiratory	respiratory	JJ
cord-001293-dfaxj3bv	241	47	distress	distress	NN
cord-001293-dfaxj3bv	241	48	syndrome	syndrome	NN
cord-001293-dfaxj3bv	241	49	Granulocyte/	Granulocyte/	NNP
cord-001293-dfaxj3bv	241	50	macrophage	macrophage	NN
cord-001293-dfaxj3bv	241	51	-	-	HYPH
cord-001293-dfaxj3bv	241	52	colony	colony	NN
cord-001293-dfaxj3bv	241	53	-	-	HYPH
cord-001293-dfaxj3bv	241	54	stimulating	stimulate	VBG
cord-001293-dfaxj3bv	241	55	factor	factor	NN
cord-001293-dfaxj3bv	241	56	(	(	-LRB-
cord-001293-dfaxj3bv	241	57	GM	GM	NNP
cord-001293-dfaxj3bv	241	58	-	-	HYPH
cord-001293-dfaxj3bv	241	59	CSF	CSF	NNP
cord-001293-dfaxj3bv	241	60	)	)	-RRB-
cord-001293-dfaxj3bv	241	61	regulates	regulate	VBZ
cord-001293-dfaxj3bv	241	62	lung	lung	NN
cord-001293-dfaxj3bv	241	63	innate	innate	JJ
cord-001293-dfaxj3bv	241	64	immunity	immunity	NN
cord-001293-dfaxj3bv	241	65	to	to	IN
cord-001293-dfaxj3bv	241	66	lipopolysaccharide	lipopolysaccharide	NN
cord-001293-dfaxj3bv	241	67	through	through	IN
cord-001293-dfaxj3bv	241	68	Akt	Akt	NNP
cord-001293-dfaxj3bv	241	69	/	/	SYM
cord-001293-dfaxj3bv	241	70	Erk	Erk	NNP
cord-001293-dfaxj3bv	241	71	activation	activation	NN
cord-001293-dfaxj3bv	241	72	of	of	IN
cord-001293-dfaxj3bv	241	73	NFkappa	NFkappa	NNP
cord-001293-dfaxj3bv	241	74	B	B	NNP
cord-001293-dfaxj3bv	241	75	and	and	CC
cord-001293-dfaxj3bv	242	1	AP-1	AP-1	NNP
cord-001293-dfaxj3bv	243	1	in	in	IN
cord-001293-dfaxj3bv	243	2	vivo	vivo	NNP
cord-001293-dfaxj3bv	243	3	GM	GM	NNP
cord-001293-dfaxj3bv	243	4	-	-	HYPH
cord-001293-dfaxj3bv	243	5	CSF	CSF	NNP
cord-001293-dfaxj3bv	243	6	signalling	signalling	NN
cord-001293-dfaxj3bv	243	7	boosts	boost	NNS
cord-001293-dfaxj3bv	243	8	dramatically	dramatically	RB
cord-001293-dfaxj3bv	243	9	IL-1	IL-1	NNP
cord-001293-dfaxj3bv	244	1	production	production	NN
cord-001293-dfaxj3bv	244	2	IL-7	IL-7	NNP
cord-001293-dfaxj3bv	244	3	restores	restore	VBZ
cord-001293-dfaxj3bv	244	4	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	244	5	functions	function	NNS
cord-001293-dfaxj3bv	244	6	in	in	IN
cord-001293-dfaxj3bv	244	7	septic	septic	JJ
cord-001293-dfaxj3bv	244	8	patients	patient	NNS
cord-001293-dfaxj3bv	245	1	Interleukin	interleukin	NN
cord-001293-dfaxj3bv	245	2	7	7	CD
cord-001293-dfaxj3bv	245	3	worsens	worsen	VBZ
cord-001293-dfaxj3bv	246	1	graft	graft	NN
cord-001293-dfaxj3bv	246	2	-	-	HYPH
cord-001293-dfaxj3bv	246	3	versus	versus	IN
cord-001293-dfaxj3bv	246	4	-	-	HYPH
cord-001293-dfaxj3bv	246	5	host	host	NN
cord-001293-dfaxj3bv	246	6	disease	disease	NN
cord-001293-dfaxj3bv	246	7	Interleukin-7	Interleukin-7	NNP
cord-001293-dfaxj3bv	246	8	receptor	receptor	NN
cord-001293-dfaxj3bv	246	9	blockade	blockade	NN
cord-001293-dfaxj3bv	246	10	suppresses	suppress	VBZ
cord-001293-dfaxj3bv	246	11	adaptive	adaptive	JJ
cord-001293-dfaxj3bv	246	12	and	and	CC
cord-001293-dfaxj3bv	246	13	innate	innate	VB
cord-001293-dfaxj3bv	246	14	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	246	15	responses	response	NNS
cord-001293-dfaxj3bv	246	16	in	in	IN
cord-001293-dfaxj3bv	246	17	experimental	experimental	JJ
cord-001293-dfaxj3bv	246	18	colitis	colitis	NN
cord-001293-dfaxj3bv	246	19	Blockade	Blockade	NNP
cord-001293-dfaxj3bv	246	20	of	of	IN
cord-001293-dfaxj3bv	246	21	the	the	DT
cord-001293-dfaxj3bv	246	22	interleukin-7	interleukin-7	NNP
cord-001293-dfaxj3bv	246	23	receptor	receptor	NN
cord-001293-dfaxj3bv	246	24	inhibits	inhibit	VBZ
cord-001293-dfaxj3bv	246	25	collagen	collagen	NN
cord-001293-dfaxj3bv	246	26	-	-	HYPH
cord-001293-dfaxj3bv	246	27	induced	induce	VBN
cord-001293-dfaxj3bv	246	28	arthritis	arthritis	NN
cord-001293-dfaxj3bv	246	29	and	and	CC
cord-001293-dfaxj3bv	246	30	is	be	VBZ
cord-001293-dfaxj3bv	246	31	associated	associate	VBN
cord-001293-dfaxj3bv	246	32	with	with	IN
cord-001293-dfaxj3bv	246	33	reduction	reduction	NN
cord-001293-dfaxj3bv	246	34	of	of	IN
cord-001293-dfaxj3bv	246	35	T	t	NN
cord-001293-dfaxj3bv	246	36	cell	cell	NN
cord-001293-dfaxj3bv	246	37	activity	activity	NN
cord-001293-dfaxj3bv	246	38	and	and	CC
cord-001293-dfaxj3bv	246	39	proinflammatory	proinflammatory	JJ
cord-001293-dfaxj3bv	246	40	mediators	mediator	NNS
cord-001293-dfaxj3bv	246	41	Systemic	systemic	JJ
cord-001293-dfaxj3bv	246	42	administration	administration	NN
cord-001293-dfaxj3bv	246	43	of	of	IN
cord-001293-dfaxj3bv	246	44	TLR3	TLR3	NNP
cord-001293-dfaxj3bv	246	45	agonist	agonist	NN
cord-001293-dfaxj3bv	246	46	induces	induce	VBZ
cord-001293-dfaxj3bv	246	47	IL-7	IL-7	NNP
cord-001293-dfaxj3bv	246	48	expression	expression	NN
cord-001293-dfaxj3bv	246	49	and	and	CC
cord-001293-dfaxj3bv	246	50	IL-7-dependent	il-7-dependent	NN
cord-001293-dfaxj3bv	246	51	CXCR3	cxcr3	NN
cord-001293-dfaxj3bv	246	52	ligand	ligand	NN
cord-001293-dfaxj3bv	246	53	production	production	NN
cord-001293-dfaxj3bv	246	54	in	in	IN
cord-001293-dfaxj3bv	246	55	the	the	DT
cord-001293-dfaxj3bv	246	56	lung	lung	NN
cord-001293-dfaxj3bv	247	1	Interleukin	Interleukin	NNP
cord-001293-dfaxj3bv	247	2	7	7	CD
cord-001293-dfaxj3bv	247	3	induces	induce	VBZ
cord-001293-dfaxj3bv	247	4	cytokine	cytokine	JJ
cord-001293-dfaxj3bv	247	5	secretion	secretion	NN
cord-001293-dfaxj3bv	247	6	and	and	CC
cord-001293-dfaxj3bv	247	7	tumoricidal	tumoricidal	JJ
cord-001293-dfaxj3bv	247	8	activity	activity	NN
cord-001293-dfaxj3bv	247	9	by	by	IN
cord-001293-dfaxj3bv	247	10	human	human	JJ
cord-001293-dfaxj3bv	247	11	peripheral	peripheral	JJ
cord-001293-dfaxj3bv	247	12	blood	blood	NN
cord-001293-dfaxj3bv	247	13	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	248	1	The	the	DT
cord-001293-dfaxj3bv	248	2	experience	experience	NN
cord-001293-dfaxj3bv	248	3	of	of	IN
cord-001293-dfaxj3bv	248	4	surgical	surgical	JJ
cord-001293-dfaxj3bv	248	5	infections	infection	NNS
cord-001293-dfaxj3bv	248	6	treatment	treatment	NN
cord-001293-dfaxj3bv	248	7	with	with	IN
cord-001293-dfaxj3bv	248	8	extracorporal	extracorporal	NNP
cord-001293-dfaxj3bv	248	9	immunotherapy	immunotherapy	NN
cord-001293-dfaxj3bv	249	1	Chloroquine	chloroquine	NN
cord-001293-dfaxj3bv	249	2	attenuates	attenuate	VBZ
cord-001293-dfaxj3bv	249	3	hemorrhagic	hemorrhagic	JJ
cord-001293-dfaxj3bv	249	4	shock	shock	NN
cord-001293-dfaxj3bv	249	5	-	-	HYPH
cord-001293-dfaxj3bv	249	6	induced	induce	VBN
cord-001293-dfaxj3bv	249	7	immunosuppression	immunosuppression	NN
cord-001293-dfaxj3bv	249	8	and	and	CC
cord-001293-dfaxj3bv	249	9	decreases	decrease	VBZ
cord-001293-dfaxj3bv	249	10	susceptibility	susceptibility	NN
cord-001293-dfaxj3bv	249	11	to	to	TO
cord-001293-dfaxj3bv	249	12	sepsis	sepsis	NN
cord-001293-dfaxj3bv	249	13	Tissue	tissue	NN
cord-001293-dfaxj3bv	249	14	compartment	compartment	NN
cord-001293-dfaxj3bv	249	15	-	-	HYPH
cord-001293-dfaxj3bv	249	16	specific	specific	JJ
cord-001293-dfaxj3bv	249	17	role	role	NN
cord-001293-dfaxj3bv	249	18	of	of	IN
cord-001293-dfaxj3bv	249	19	estrogen	estrogen	NN
cord-001293-dfaxj3bv	249	20	receptor	receptor	NN
cord-001293-dfaxj3bv	249	21	subtypes	subtype	NNS
cord-001293-dfaxj3bv	249	22	in	in	IN
cord-001293-dfaxj3bv	249	23	immune	immune	JJ
cord-001293-dfaxj3bv	249	24	cell	cell	NN
cord-001293-dfaxj3bv	249	25	cytokine	cytokine	NN
cord-001293-dfaxj3bv	249	26	production	production	NN
cord-001293-dfaxj3bv	249	27	following	follow	VBG
cord-001293-dfaxj3bv	250	1	trauma	trauma	NN
cord-001293-dfaxj3bv	250	2	-	-	HYPH
cord-001293-dfaxj3bv	250	3	hemorrhage	hemorrhage	NN
cord-001293-dfaxj3bv	250	4	Infection	infection	NN
cord-001293-dfaxj3bv	250	5	regulates	regulate	VBZ
cord-001293-dfaxj3bv	250	6	pro	pro	JJ
cord-001293-dfaxj3bv	250	7	-	-	JJ
cord-001293-dfaxj3bv	250	8	resolving	resolve	VBG
cord-001293-dfaxj3bv	250	9	mediators	mediator	NNS
cord-001293-dfaxj3bv	250	10	that	that	WDT
cord-001293-dfaxj3bv	250	11	lower	lower	VBP
cord-001293-dfaxj3bv	250	12	antibiotic	antibiotic	JJ
cord-001293-dfaxj3bv	250	13	requirements	requirement	NNS
cord-001293-dfaxj3bv	250	14	Acetyl	acetyl	NN
cord-001293-dfaxj3bv	250	15	salicylic	salicylic	JJ
cord-001293-dfaxj3bv	250	16	acid	acid	NN
cord-001293-dfaxj3bv	250	17	usage	usage	NN
cord-001293-dfaxj3bv	250	18	and	and	CC
cord-001293-dfaxj3bv	250	19	mortality	mortality	NN
cord-001293-dfaxj3bv	250	20	in	in	IN
cord-001293-dfaxj3bv	250	21	critically	critically	RB
cord-001293-dfaxj3bv	250	22	ill	ill	JJ
cord-001293-dfaxj3bv	250	23	patients	patient	NNS
cord-001293-dfaxj3bv	250	24	with	with	IN
cord-001293-dfaxj3bv	250	25	the	the	DT
cord-001293-dfaxj3bv	250	26	systemic	systemic	JJ
cord-001293-dfaxj3bv	250	27	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	250	28	response	response	NN
cord-001293-dfaxj3bv	250	29	syndrome	syndrome	NN
cord-001293-dfaxj3bv	250	30	and	and	CC
cord-001293-dfaxj3bv	250	31	sepsis	sepsis	NN
cord-001293-dfaxj3bv	251	1	The	the	DT
cord-001293-dfaxj3bv	251	2	efficacy	efficacy	NN
cord-001293-dfaxj3bv	251	3	of	of	IN
cord-001293-dfaxj3bv	251	4	thymosin	thymosin	NNP
cord-001293-dfaxj3bv	251	5	alpha	alpha	NN
cord-001293-dfaxj3bv	251	6	1	1	CD
cord-001293-dfaxj3bv	251	7	for	for	IN
cord-001293-dfaxj3bv	251	8	severe	severe	JJ
cord-001293-dfaxj3bv	251	9	sepsis	sepsis	NN
cord-001293-dfaxj3bv	251	10	(	(	-LRB-
cord-001293-dfaxj3bv	251	11	ETASS	ETASS	NNP
cord-001293-dfaxj3bv	251	12	)	)	-RRB-
cord-001293-dfaxj3bv	251	13	:	:	:
cord-001293-dfaxj3bv	251	14	a	a	DT
cord-001293-dfaxj3bv	251	15	multicenter	multicenter	JJ
cord-001293-dfaxj3bv	251	16	,	,	,
cord-001293-dfaxj3bv	251	17	single	single	JJ
cord-001293-dfaxj3bv	251	18	-	-	HYPH
cord-001293-dfaxj3bv	251	19	blind	blind	JJ
cord-001293-dfaxj3bv	251	20	,	,	,
cord-001293-dfaxj3bv	251	21	randomized	randomized	JJ
cord-001293-dfaxj3bv	251	22	and	and	CC
cord-001293-dfaxj3bv	251	23	controlled	control	VBN
cord-001293-dfaxj3bv	251	24	trial	trial	NN
cord-001293-dfaxj3bv	251	25	Thymosin	Thymosin	NNP
cord-001293-dfaxj3bv	251	26	alpha1-and	alpha1-and	DT
cord-001293-dfaxj3bv	251	27	ulinastatin	ulinastatin	RB
cord-001293-dfaxj3bv	251	28	-	-	HYPH
cord-001293-dfaxj3bv	251	29	based	base	VBN
cord-001293-dfaxj3bv	251	30	immunomodulatory	immunomodulatory	JJ
cord-001293-dfaxj3bv	251	31	strategy	strategy	NN
cord-001293-dfaxj3bv	251	32	for	for	IN
cord-001293-dfaxj3bv	251	33	sepsis	sepsis	NN
cord-001293-dfaxj3bv	251	34	arising	arise	VBG
cord-001293-dfaxj3bv	251	35	from	from	IN
cord-001293-dfaxj3bv	251	36	intra	intra	JJ
cord-001293-dfaxj3bv	251	37	-	-	JJ
cord-001293-dfaxj3bv	251	38	abdominal	abdominal	JJ
cord-001293-dfaxj3bv	251	39	infection	infection	NN
cord-001293-dfaxj3bv	251	40	due	due	IN
cord-001293-dfaxj3bv	251	41	to	to	IN
cord-001293-dfaxj3bv	251	42	carbapenemresistant	carbapenemresistant	JJ
cord-001293-dfaxj3bv	251	43	bacteria	bacteria	NNS
cord-001293-dfaxj3bv	251	44	Involvement	Involvement	NNP
cord-001293-dfaxj3bv	251	45	of	of	IN
cord-001293-dfaxj3bv	251	46	mitogen	mitogen	NNP
cord-001293-dfaxj3bv	251	47	-	-	HYPH
cord-001293-dfaxj3bv	251	48	activated	activate	VBN
cord-001293-dfaxj3bv	251	49	protein	protein	NN
cord-001293-dfaxj3bv	251	50	kinases	kinase	NNS
cord-001293-dfaxj3bv	251	51	in	in	IN
cord-001293-dfaxj3bv	251	52	the	the	DT
cord-001293-dfaxj3bv	251	53	signal	signal	NN
cord-001293-dfaxj3bv	251	54	transduction	transduction	NN
cord-001293-dfaxj3bv	251	55	pathway	pathway	NN
cord-001293-dfaxj3bv	251	56	of	of	IN
cord-001293-dfaxj3bv	251	57	bone	bone	NN
cord-001293-dfaxj3bv	251	58	marrow	marrow	NN
cord-001293-dfaxj3bv	251	59	-	-	HYPH
cord-001293-dfaxj3bv	251	60	derived	derive	VBN
cord-001293-dfaxj3bv	251	61	macrophage	macrophage	NN
cord-001293-dfaxj3bv	251	62	activation	activation	NN
cord-001293-dfaxj3bv	251	63	in	in	IN
cord-001293-dfaxj3bv	251	64	response	response	NN
cord-001293-dfaxj3bv	251	65	to	to	IN
cord-001293-dfaxj3bv	251	66	in	in	FW
cord-001293-dfaxj3bv	251	67	vitro	vitro	FW
cord-001293-dfaxj3bv	251	68	treatment	treatment	NN
cord-001293-dfaxj3bv	251	69	with	with	IN
cord-001293-dfaxj3bv	251	70	thymosin	thymosin	NNP
cord-001293-dfaxj3bv	251	71	alpha	alpha	NNP
cord-001293-dfaxj3bv	251	72	1	1	CD
cord-001293-dfaxj3bv	251	73	Effect	Effect	NNP
cord-001293-dfaxj3bv	251	74	of	of	IN
cord-001293-dfaxj3bv	251	75	thymosin	thymosin	VBG
cord-001293-dfaxj3bv	251	76	alpha-1	alpha-1	NN
cord-001293-dfaxj3bv	251	77	on	on	IN
cord-001293-dfaxj3bv	251	78	subpopulations	subpopulation	NNS
cord-001293-dfaxj3bv	251	79	of	of	IN
cord-001293-dfaxj3bv	251	80	Th1	th1	NN
cord-001293-dfaxj3bv	251	81	,	,	,
cord-001293-dfaxj3bv	251	82	Th2	th2	CD
cord-001293-dfaxj3bv	251	83	,	,	,
cord-001293-dfaxj3bv	251	84	Th17	Th17	NNP
cord-001293-dfaxj3bv	251	85	,	,	,
cord-001293-dfaxj3bv	251	86	and	and	CC
cord-001293-dfaxj3bv	251	87	regulatory	regulatory	JJ
cord-001293-dfaxj3bv	251	88	T	t	NN
cord-001293-dfaxj3bv	251	89	cells	cell	NNS
cord-001293-dfaxj3bv	251	90	(	(	-LRB-
cord-001293-dfaxj3bv	251	91	Tregs	Tregs	NNP
cord-001293-dfaxj3bv	251	92	)	)	-RRB-
cord-001293-dfaxj3bv	252	1	in	in	IN
cord-001293-dfaxj3bv	252	2	vitro	vitro	FW
cord-001293-dfaxj3bv	252	3	Programmed	program	VBD
cord-001293-dfaxj3bv	252	4	death	death	NN
cord-001293-dfaxj3bv	252	5	1	1	CD
cord-001293-dfaxj3bv	252	6	expression	expression	NN
cord-001293-dfaxj3bv	252	7	as	as	IN
cord-001293-dfaxj3bv	252	8	a	a	DT
cord-001293-dfaxj3bv	252	9	marker	marker	NN
cord-001293-dfaxj3bv	252	10	for	for	IN
cord-001293-dfaxj3bv	252	11	immune	immune	JJ
cord-001293-dfaxj3bv	252	12	and	and	CC
cord-001293-dfaxj3bv	252	13	physiological	physiological	JJ
cord-001293-dfaxj3bv	252	14	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	252	15	in	in	IN
cord-001293-dfaxj3bv	252	16	the	the	DT
cord-001293-dfaxj3bv	252	17	critically	critically	RB
cord-001293-dfaxj3bv	252	18	ill	ill	JJ
cord-001293-dfaxj3bv	252	19	surgical	surgical	JJ
cord-001293-dfaxj3bv	252	20	patient	patient	NN
cord-001293-dfaxj3bv	252	21	Upregulation	Upregulation	NNP
cord-001293-dfaxj3bv	252	22	of	of	IN
cord-001293-dfaxj3bv	252	23	programmed	program	VBN
cord-001293-dfaxj3bv	252	24	death-1	death-1	NNP
cord-001293-dfaxj3bv	252	25	on	on	IN
cord-001293-dfaxj3bv	252	26	T	T	NNP
cord-001293-dfaxj3bv	252	27	cells	cell	NNS
cord-001293-dfaxj3bv	252	28	and	and	CC
cord-001293-dfaxj3bv	252	29	programmed	program	VBD
cord-001293-dfaxj3bv	252	30	death	death	NN
cord-001293-dfaxj3bv	252	31	ligand-1	ligand-1	NNP
cord-001293-dfaxj3bv	252	32	on	on	IN
cord-001293-dfaxj3bv	252	33	monocytes	monocyte	NNS
cord-001293-dfaxj3bv	252	34	in	in	IN
cord-001293-dfaxj3bv	252	35	septic	septic	JJ
cord-001293-dfaxj3bv	252	36	shock	shock	NN
cord-001293-dfaxj3bv	252	37	patients	patient	NNS
cord-001293-dfaxj3bv	252	38	Programmed	program	VBN
cord-001293-dfaxj3bv	252	39	death-1	death-1	NNP
cord-001293-dfaxj3bv	252	40	levels	level	NNS
cord-001293-dfaxj3bv	252	41	correlate	correlate	VBP
cord-001293-dfaxj3bv	252	42	with	with	IN
cord-001293-dfaxj3bv	252	43	increased	increase	VBN
cord-001293-dfaxj3bv	252	44	mortality	mortality	NN
cord-001293-dfaxj3bv	252	45	,	,	,
cord-001293-dfaxj3bv	252	46	nosocomial	nosocomial	JJ
cord-001293-dfaxj3bv	252	47	infection	infection	NN
cord-001293-dfaxj3bv	252	48	and	and	CC
cord-001293-dfaxj3bv	252	49	immune	immune	JJ
cord-001293-dfaxj3bv	252	50	dysfunctions	dysfunction	NNS
cord-001293-dfaxj3bv	252	51	in	in	IN
cord-001293-dfaxj3bv	252	52	septic	septic	JJ
cord-001293-dfaxj3bv	252	53	shock	shock	NN
cord-001293-dfaxj3bv	252	54	patients	patient	NNS
cord-001293-dfaxj3bv	253	1	PD-1	pd-1	DT
cord-001293-dfaxj3bv	253	2	expression	expression	NN
cord-001293-dfaxj3bv	253	3	by	by	IN
cord-001293-dfaxj3bv	253	4	macrophages	macrophage	NNS
cord-001293-dfaxj3bv	253	5	plays	play	VBZ
cord-001293-dfaxj3bv	253	6	a	a	DT
cord-001293-dfaxj3bv	253	7	pathologic	pathologic	JJ
cord-001293-dfaxj3bv	253	8	role	role	NN
cord-001293-dfaxj3bv	253	9	in	in	IN
cord-001293-dfaxj3bv	253	10	altering	alter	VBG
cord-001293-dfaxj3bv	253	11	microbial	microbial	JJ
cord-001293-dfaxj3bv	253	12	clearance	clearance	NN
cord-001293-dfaxj3bv	253	13	and	and	CC
cord-001293-dfaxj3bv	253	14	the	the	DT
cord-001293-dfaxj3bv	253	15	innate	innate	JJ
cord-001293-dfaxj3bv	253	16	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	253	17	response	response	NN
cord-001293-dfaxj3bv	253	18	to	to	IN
cord-001293-dfaxj3bv	253	19	sepsis	sepsis	NN
cord-001293-dfaxj3bv	253	20	Delayed	delay	VBN
cord-001293-dfaxj3bv	253	21	administration	administration	NN
cord-001293-dfaxj3bv	253	22	of	of	IN
cord-001293-dfaxj3bv	253	23	anti	anti	JJ
cord-001293-dfaxj3bv	253	24	-	-	JJ
cord-001293-dfaxj3bv	253	25	PD-1	pd-1	JJ
cord-001293-dfaxj3bv	253	26	antibody	antibody	NN
cord-001293-dfaxj3bv	253	27	reverses	reverse	VBZ
cord-001293-dfaxj3bv	253	28	immune	immune	JJ
cord-001293-dfaxj3bv	253	29	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	253	30	and	and	CC
cord-001293-dfaxj3bv	253	31	improves	improve	VBZ
cord-001293-dfaxj3bv	253	32	survival	survival	NN
cord-001293-dfaxj3bv	253	33	during	during	IN
cord-001293-dfaxj3bv	253	34	sepsis	sepsis	NN
cord-001293-dfaxj3bv	253	35	PD	PD	NNP
cord-001293-dfaxj3bv	253	36	-	-	HYPH
cord-001293-dfaxj3bv	253	37	L1	L1	NNP
cord-001293-dfaxj3bv	253	38	blockade	blockade	NN
cord-001293-dfaxj3bv	253	39	improves	improve	VBZ
cord-001293-dfaxj3bv	253	40	survival	survival	NN
cord-001293-dfaxj3bv	253	41	in	in	IN
cord-001293-dfaxj3bv	253	42	experimental	experimental	JJ
cord-001293-dfaxj3bv	253	43	sepsis	sepsis	NN
cord-001293-dfaxj3bv	253	44	by	by	IN
cord-001293-dfaxj3bv	253	45	inhibiting	inhibit	VBG
cord-001293-dfaxj3bv	253	46	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	253	47	apoptosis	apoptosis	NN
cord-001293-dfaxj3bv	253	48	and	and	CC
cord-001293-dfaxj3bv	253	49	reversing	reverse	VBG
cord-001293-dfaxj3bv	253	50	monocyte	monocyte	NNP
cord-001293-dfaxj3bv	253	51	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	253	52	PD	PD	NNP
cord-001293-dfaxj3bv	253	53	-	-	HYPH
cord-001293-dfaxj3bv	253	54	L1	L1	NNP
cord-001293-dfaxj3bv	253	55	blockade	blockade	NN
cord-001293-dfaxj3bv	253	56	attenuated	attenuate	VBN
cord-001293-dfaxj3bv	253	57	sepsis	sepsis	NN
cord-001293-dfaxj3bv	253	58	-	-	HYPH
cord-001293-dfaxj3bv	253	59	induced	induce	VBN
cord-001293-dfaxj3bv	253	60	liver	liver	NN
cord-001293-dfaxj3bv	253	61	injury	injury	NN
cord-001293-dfaxj3bv	253	62	in	in	IN
cord-001293-dfaxj3bv	253	63	a	a	DT
cord-001293-dfaxj3bv	253	64	mouse	mouse	NN
cord-001293-dfaxj3bv	253	65	cecal	cecal	NN
cord-001293-dfaxj3bv	253	66	ligation	ligation	NN
cord-001293-dfaxj3bv	253	67	and	and	CC
cord-001293-dfaxj3bv	253	68	puncture	puncture	NN
cord-001293-dfaxj3bv	253	69	model	model	NN
cord-001293-dfaxj3bv	254	1	Decreased	decrease	VBN
cord-001293-dfaxj3bv	254	2	response	response	NN
cord-001293-dfaxj3bv	254	3	to	to	TO
cord-001293-dfaxj3bv	254	4	recall	recall	VB
cord-001293-dfaxj3bv	254	5	antigens	antigen	NNS
cord-001293-dfaxj3bv	254	6	is	be	VBZ
cord-001293-dfaxj3bv	254	7	associated	associate	VBN
cord-001293-dfaxj3bv	254	8	with	with	IN
cord-001293-dfaxj3bv	254	9	depressed	depressed	JJ
cord-001293-dfaxj3bv	254	10	costimulatory	costimulatory	NNP
cord-001293-dfaxj3bv	254	11	receptor	receptor	NN
cord-001293-dfaxj3bv	254	12	expression	expression	NN
cord-001293-dfaxj3bv	254	13	in	in	IN
cord-001293-dfaxj3bv	254	14	septic	septic	JJ
cord-001293-dfaxj3bv	254	15	critically	critically	RB
cord-001293-dfaxj3bv	254	16	ill	ill	JJ
cord-001293-dfaxj3bv	254	17	patients	patient	NNS
cord-001293-dfaxj3bv	254	18	Dose	dose	NN
cord-001293-dfaxj3bv	254	19	-	-	HYPH
cord-001293-dfaxj3bv	254	20	dependent	dependent	JJ
cord-001293-dfaxj3bv	254	21	effect	effect	NN
cord-001293-dfaxj3bv	254	22	of	of	IN
cord-001293-dfaxj3bv	254	23	anti	anti	NNS
cord-001293-dfaxj3bv	254	24	-	-	NNS
cord-001293-dfaxj3bv	254	25	CTLA-4	CTLA-4	NNS
cord-001293-dfaxj3bv	254	26	on	on	IN
cord-001293-dfaxj3bv	254	27	survival	survival	NN
cord-001293-dfaxj3bv	254	28	in	in	IN
cord-001293-dfaxj3bv	254	29	sepsis	sepsis	NN
cord-001293-dfaxj3bv	254	30	Blockade	blockade	NN
cord-001293-dfaxj3bv	254	31	of	of	IN
cord-001293-dfaxj3bv	254	32	the	the	DT
cord-001293-dfaxj3bv	254	33	negative	negative	JJ
cord-001293-dfaxj3bv	254	34	co	co	JJ
cord-001293-dfaxj3bv	254	35	-	-	JJ
cord-001293-dfaxj3bv	254	36	stimulatory	stimulatory	JJ
cord-001293-dfaxj3bv	254	37	molecules	molecule	NNS
cord-001293-dfaxj3bv	255	1	PD-1	PD-1	NNP
cord-001293-dfaxj3bv	256	1	and	and	CC
cord-001293-dfaxj3bv	256	2	CTLA-4	CTLA-4	NNP
cord-001293-dfaxj3bv	256	3	improves	improve	VBZ
cord-001293-dfaxj3bv	256	4	survival	survival	NN
cord-001293-dfaxj3bv	256	5	in	in	IN
cord-001293-dfaxj3bv	256	6	primary	primary	JJ
cord-001293-dfaxj3bv	256	7	and	and	CC
cord-001293-dfaxj3bv	256	8	secondary	secondary	JJ
cord-001293-dfaxj3bv	256	9	fungal	fungal	NN
cord-001293-dfaxj3bv	256	10	sepsis	sepsis	NN
cord-001293-dfaxj3bv	257	1	Inhibition	inhibition	NN
cord-001293-dfaxj3bv	257	2	of	of	IN
cord-001293-dfaxj3bv	257	3	T	T	NNP
cord-001293-dfaxj3bv	257	4	cells	cell	NNS
cord-001293-dfaxj3bv	257	5	provides	provide	VBZ
cord-001293-dfaxj3bv	257	6	protection	protection	NN
cord-001293-dfaxj3bv	257	7	against	against	IN
cord-001293-dfaxj3bv	257	8	early	early	JJ
cord-001293-dfaxj3bv	257	9	invasive	invasive	JJ
cord-001293-dfaxj3bv	257	10	pneumococcal	pneumococcal	JJ
cord-001293-dfaxj3bv	257	11	disease	disease	NN
cord-001293-dfaxj3bv	257	12	B	b	NN
cord-001293-dfaxj3bv	257	13	and	and	CC
cord-001293-dfaxj3bv	257	14	T	T	NNP
cord-001293-dfaxj3bv	257	15	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	257	16	attenuator	attenuator	NN
cord-001293-dfaxj3bv	257	17	expression	expression	NN
cord-001293-dfaxj3bv	257	18	on	on	IN
cord-001293-dfaxj3bv	257	19	CD4	CD4	NNP
cord-001293-dfaxj3bv	257	20	+	+	CC
cord-001293-dfaxj3bv	257	21	T	T	NNP
cord-001293-dfaxj3bv	257	22	-	-	HYPH
cord-001293-dfaxj3bv	257	23	cells	cell	NNS
cord-001293-dfaxj3bv	257	24	associates	associate	NNS
cord-001293-dfaxj3bv	257	25	with	with	IN
cord-001293-dfaxj3bv	257	26	sepsis	sepsis	NN
cord-001293-dfaxj3bv	257	27	and	and	CC
cord-001293-dfaxj3bv	257	28	subsequent	subsequent	JJ
cord-001293-dfaxj3bv	257	29	infections	infection	NNS
cord-001293-dfaxj3bv	257	30	in	in	IN
cord-001293-dfaxj3bv	257	31	ICU	ICU	NNP
cord-001293-dfaxj3bv	257	32	patients	patient	NNS
cord-001293-dfaxj3bv	257	33	BTLA	BTLA	NNP
cord-001293-dfaxj3bv	257	34	expression	expression	NN
cord-001293-dfaxj3bv	257	35	contributes	contribute	VBZ
cord-001293-dfaxj3bv	257	36	to	to	IN
cord-001293-dfaxj3bv	257	37	septic	septic	JJ
cord-001293-dfaxj3bv	257	38	morbidity	morbidity	NN
cord-001293-dfaxj3bv	257	39	and	and	CC
cord-001293-dfaxj3bv	257	40	mortality	mortality	NN
cord-001293-dfaxj3bv	257	41	by	by	IN
cord-001293-dfaxj3bv	257	42	inducing	induce	VBG
cord-001293-dfaxj3bv	257	43	innate	innate	JJ
cord-001293-dfaxj3bv	257	44	inflammatory	inflammatory	JJ
cord-001293-dfaxj3bv	257	45	cell	cell	NN
cord-001293-dfaxj3bv	257	46	dysfunction	dysfunction	NN
cord-001293-dfaxj3bv	257	47	B	B	NNP
cord-001293-dfaxj3bv	257	48	and	and	CC
cord-001293-dfaxj3bv	257	49	T	t	NN
cord-001293-dfaxj3bv	257	50	lymphocyte	lymphocyte	NN
cord-001293-dfaxj3bv	257	51	attenuator	attenuator	NN
cord-001293-dfaxj3bv	257	52	inhibits	inhibit	VBZ
cord-001293-dfaxj3bv	257	53	LPS	LPS	NNP
cord-001293-dfaxj3bv	257	54	-	-	HYPH
cord-001293-dfaxj3bv	257	55	induced	induce	VBN
cord-001293-dfaxj3bv	257	56	endotoxic	endotoxic	JJ
cord-001293-dfaxj3bv	257	57	shock	shock	NN
cord-001293-dfaxj3bv	257	58	by	by	IN
cord-001293-dfaxj3bv	257	59	suppressing	suppress	VBG
cord-001293-dfaxj3bv	257	60	Toll	Toll	NNP
cord-001293-dfaxj3bv	257	61	-	-	HYPH
cord-001293-dfaxj3bv	257	62	like	like	JJ
cord-001293-dfaxj3bv	257	63	receptor	receptor	NN
cord-001293-dfaxj3bv	257	64	4	4	CD
cord-001293-dfaxj3bv	257	65	signaling	signal	VBG
cord-001293-dfaxj3bv	257	66	in	in	IN
cord-001293-dfaxj3bv	257	67	innate	innate	JJ
cord-001293-dfaxj3bv	257	68	immune	immune	JJ
cord-001293-dfaxj3bv	257	69	cells	cell	NNS
cord-001293-dfaxj3bv	257	70	Cite	cite	VBP
cord-001293-dfaxj3bv	257	71	this	this	DT
cord-001293-dfaxj3bv	257	72	article	article	NN
cord-001293-dfaxj3bv	257	73	as	as	IN
cord-001293-dfaxj3bv	257	74	:	:	:
cord-001293-dfaxj3bv	257	75	Cavaillon	Cavaillon	NNP
cord-001293-dfaxj3bv	257	76	et	et	NNP
cord-001293-dfaxj3bv	257	77	al	al	NNP
cord-001293-dfaxj3bv	257	78	.	.	.
cord-001293-dfaxj3bv	257	79	:	:	:
cord-001293-dfaxj3bv	258	1	Is	be	VBZ
cord-001293-dfaxj3bv	258	2	boosting	boost	VBG
cord-001293-dfaxj3bv	258	3	the	the	DT
cord-001293-dfaxj3bv	258	4	immune	immune	JJ
cord-001293-dfaxj3bv	258	5	system	system	NN
cord-001293-dfaxj3bv	258	6	in	in	IN
cord-001293-dfaxj3bv	258	7	sepsis	sepsis	NN
cord-001293-dfaxj3bv	258	8	appropriate	appropriate	JJ
cord-001293-dfaxj3bv	258	9	?	?	.
cord-001293-dfaxj3bv	259	1	Critical	Critical	NNP
cord-001293-dfaxj3bv	259	2	Care	Care	NNP