id	sid	tid	token	lemma	pos
cord-002209-xs6qigg4	1	1	key	key	NN
cord-002209-xs6qigg4	1	2	:	:	:
cord-002209-xs6qigg4	2	1	cord-002209-xs6qigg4	cord-002209-xs6qigg4	NNP
cord-002209-xs6qigg4	2	2	authors	author	NNS
cord-002209-xs6qigg4	2	3	:	:	:
cord-002209-xs6qigg4	2	4	Kıray	Kıray	NNP
cord-002209-xs6qigg4	2	5	,	,	,
cord-002209-xs6qigg4	2	6	Hülya	Hülya	NNP
cord-002209-xs6qigg4	2	7	;	;	:
cord-002209-xs6qigg4	2	8	Lindsay	Lindsay	NNP
cord-002209-xs6qigg4	2	9	,	,	,
cord-002209-xs6qigg4	2	10	Susan	Susan	NNP
cord-002209-xs6qigg4	2	11	L.	L.	NNP
cord-002209-xs6qigg4	2	12	;	;	:
cord-002209-xs6qigg4	2	13	Hosseinzadeh	Hosseinzadeh	NNP
cord-002209-xs6qigg4	2	14	,	,	,
cord-002209-xs6qigg4	2	15	Sara	Sara	NNP
cord-002209-xs6qigg4	2	16	;	;	:
cord-002209-xs6qigg4	2	17	Barnett	Barnett	NNP
cord-002209-xs6qigg4	2	18	,	,	,
cord-002209-xs6qigg4	2	19	Susan	Susan	NNP
cord-002209-xs6qigg4	2	20	C.	C.	NNP
cord-002209-xs6qigg4	2	21	title	title	NN
cord-002209-xs6qigg4	2	22	:	:	:
cord-002209-xs6qigg4	3	1	The	the	DT
cord-002209-xs6qigg4	3	2	multifaceted	multifaceted	JJ
cord-002209-xs6qigg4	3	3	role	role	NN
cord-002209-xs6qigg4	3	4	of	of	IN
cord-002209-xs6qigg4	3	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	3	6	in	in	IN
cord-002209-xs6qigg4	3	7	regulating	regulate	VBG
cord-002209-xs6qigg4	3	8	myelination	myelination	NN
cord-002209-xs6qigg4	3	9	date	date	NN
cord-002209-xs6qigg4	3	10	:	:	:
cord-002209-xs6qigg4	3	11	2016	2016	CD
cord-002209-xs6qigg4	3	12	-	-	HYPH
cord-002209-xs6qigg4	3	13	09	09	CD
cord-002209-xs6qigg4	3	14	-	-	SYM
cord-002209-xs6qigg4	3	15	17	17	CD
cord-002209-xs6qigg4	3	16	journal	journal	NN
cord-002209-xs6qigg4	3	17	:	:	:
cord-002209-xs6qigg4	4	1	Exp	Exp	NNP
cord-002209-xs6qigg4	4	2	Neurol	Neurol	NNP
cord-002209-xs6qigg4	4	3	DOI	DOI	NNP
cord-002209-xs6qigg4	4	4	:	:	:
cord-002209-xs6qigg4	4	5	10.1016	10.1016	CD
cord-002209-xs6qigg4	4	6	/	/	SYM
cord-002209-xs6qigg4	4	7	j.expneurol.2016.03.009	j.expneurol.2016.03.009	NNP
cord-002209-xs6qigg4	4	8	sha	sha	NNP
cord-002209-xs6qigg4	4	9	:	:	:
cord-002209-xs6qigg4	5	1	4aa6c6d082407bee2de3cfdc3a8a11a229904fda	4aa6c6d082407bee2de3cfdc3a8a11a229904fda	CD
cord-002209-xs6qigg4	5	2	doc_id	doc_id	CD
cord-002209-xs6qigg4	5	3	:	:	:
cord-002209-xs6qigg4	6	1	2209	2209	CD
cord-002209-xs6qigg4	6	2	cord_uid	cord_uid	NN
cord-002209-xs6qigg4	6	3	:	:	:
cord-002209-xs6qigg4	7	1	xs6qigg4	xs6qigg4	NNP
cord-002209-xs6qigg4	7	2	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	7	3	are	be	VBP
cord-002209-xs6qigg4	7	4	the	the	DT
cord-002209-xs6qigg4	7	5	major	major	JJ
cord-002209-xs6qigg4	7	6	glial	glial	JJ
cord-002209-xs6qigg4	7	7	cell	cell	NN
cord-002209-xs6qigg4	7	8	of	of	IN
cord-002209-xs6qigg4	7	9	the	the	DT
cord-002209-xs6qigg4	7	10	central	central	JJ
cord-002209-xs6qigg4	7	11	nervous	nervous	JJ
cord-002209-xs6qigg4	7	12	system	system	NN
cord-002209-xs6qigg4	7	13	(	(	-LRB-
cord-002209-xs6qigg4	7	14	CNS	CNS	NNP
cord-002209-xs6qigg4	7	15	)	)	-RRB-
cord-002209-xs6qigg4	7	16	,	,	,
cord-002209-xs6qigg4	7	17	providing	provide	VBG
cord-002209-xs6qigg4	7	18	both	both	DT
cord-002209-xs6qigg4	7	19	metabolic	metabolic	JJ
cord-002209-xs6qigg4	7	20	and	and	CC
cord-002209-xs6qigg4	7	21	physical	physical	JJ
cord-002209-xs6qigg4	7	22	support	support	NN
cord-002209-xs6qigg4	7	23	to	to	IN
cord-002209-xs6qigg4	7	24	other	other	JJ
cord-002209-xs6qigg4	7	25	neural	neural	JJ
cord-002209-xs6qigg4	7	26	cells	cell	NNS
cord-002209-xs6qigg4	7	27	.	.	.
cord-002209-xs6qigg4	8	1	After	after	IN
cord-002209-xs6qigg4	8	2	injury	injury	NN
cord-002209-xs6qigg4	8	3	,	,	,
cord-002209-xs6qigg4	8	4	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	8	5	become	become	VBP
cord-002209-xs6qigg4	8	6	reactive	reactive	JJ
cord-002209-xs6qigg4	8	7	and	and	CC
cord-002209-xs6qigg4	8	8	express	express	VB
cord-002209-xs6qigg4	8	9	a	a	DT
cord-002209-xs6qigg4	8	10	continuum	continuum	NN
cord-002209-xs6qigg4	8	11	of	of	IN
cord-002209-xs6qigg4	8	12	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	8	13	which	which	WDT
cord-002209-xs6qigg4	8	14	may	may	MD
cord-002209-xs6qigg4	8	15	be	be	VB
cord-002209-xs6qigg4	8	16	supportive	supportive	JJ
cord-002209-xs6qigg4	8	17	or	or	CC
cord-002209-xs6qigg4	8	18	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	8	19	to	to	IN
cord-002209-xs6qigg4	8	20	CNS	CNS	NNP
cord-002209-xs6qigg4	8	21	repair	repair	NN
cord-002209-xs6qigg4	8	22	.	.	.
cord-002209-xs6qigg4	9	1	This	this	DT
cord-002209-xs6qigg4	9	2	review	review	NN
cord-002209-xs6qigg4	9	3	will	will	MD
cord-002209-xs6qigg4	9	4	focus	focus	VB
cord-002209-xs6qigg4	9	5	on	on	IN
cord-002209-xs6qigg4	9	6	the	the	DT
cord-002209-xs6qigg4	9	7	ability	ability	NN
cord-002209-xs6qigg4	9	8	of	of	IN
cord-002209-xs6qigg4	9	9	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	9	10	to	to	TO
cord-002209-xs6qigg4	9	11	influence	influence	VB
cord-002209-xs6qigg4	9	12	myelination	myelination	NN
cord-002209-xs6qigg4	9	13	in	in	IN
cord-002209-xs6qigg4	9	14	the	the	DT
cord-002209-xs6qigg4	9	15	context	context	NN
cord-002209-xs6qigg4	9	16	of	of	IN
cord-002209-xs6qigg4	9	17	specific	specific	JJ
cord-002209-xs6qigg4	9	18	secreted	secrete	VBN
cord-002209-xs6qigg4	9	19	factors	factor	NNS
cord-002209-xs6qigg4	9	20	,	,	,
cord-002209-xs6qigg4	9	21	cytokines	cytokine	NNS
cord-002209-xs6qigg4	9	22	and	and	CC
cord-002209-xs6qigg4	9	23	other	other	JJ
cord-002209-xs6qigg4	9	24	neural	neural	JJ
cord-002209-xs6qigg4	9	25	cell	cell	NN
cord-002209-xs6qigg4	9	26	targets	target	NNS
cord-002209-xs6qigg4	9	27	within	within	IN
cord-002209-xs6qigg4	9	28	the	the	DT
cord-002209-xs6qigg4	9	29	CNS	CNS	NNP
cord-002209-xs6qigg4	9	30	.	.	.
cord-002209-xs6qigg4	10	1	In	in	IN
cord-002209-xs6qigg4	10	2	particular	particular	JJ
cord-002209-xs6qigg4	10	3	,	,	,
cord-002209-xs6qigg4	10	4	we	-PRON-	PRP
cord-002209-xs6qigg4	10	5	focus	focus	VBP
cord-002209-xs6qigg4	10	6	on	on	IN
cord-002209-xs6qigg4	10	7	how	how	WRB
cord-002209-xs6qigg4	10	8	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	10	9	provide	provide	VBP
cord-002209-xs6qigg4	10	10	energy	energy	NN
cord-002209-xs6qigg4	10	11	and	and	CC
cord-002209-xs6qigg4	10	12	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	10	13	to	to	IN
cord-002209-xs6qigg4	10	14	neurons	neuron	NNS
cord-002209-xs6qigg4	10	15	,	,	,
cord-002209-xs6qigg4	10	16	influence	influence	NN
cord-002209-xs6qigg4	10	17	synaptogenesis	synaptogenesis	NN
cord-002209-xs6qigg4	10	18	,	,	,
cord-002209-xs6qigg4	10	19	affect	affect	VB
cord-002209-xs6qigg4	10	20	oligodendrocyte	oligodendrocyte	JJ
cord-002209-xs6qigg4	10	21	biology	biology	NN
cord-002209-xs6qigg4	10	22	and	and	CC
cord-002209-xs6qigg4	10	23	instigate	instigate	VB
cord-002209-xs6qigg4	10	24	cross	cross	NN
cord-002209-xs6qigg4	10	25	-	-	NN
cord-002209-xs6qigg4	10	26	talk	talk	NN
cord-002209-xs6qigg4	10	27	between	between	IN
cord-002209-xs6qigg4	10	28	the	the	DT
cord-002209-xs6qigg4	10	29	many	many	JJ
cord-002209-xs6qigg4	10	30	cellular	cellular	JJ
cord-002209-xs6qigg4	10	31	components	component	NNS
cord-002209-xs6qigg4	10	32	of	of	IN
cord-002209-xs6qigg4	10	33	the	the	DT
cord-002209-xs6qigg4	10	34	CNS	CNS	NNP
cord-002209-xs6qigg4	10	35	.	.	.
cord-002209-xs6qigg4	11	1	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	11	2	were	be	VBD
cord-002209-xs6qigg4	11	3	long	long	RB
cord-002209-xs6qigg4	11	4	considered	consider	VBN
cord-002209-xs6qigg4	11	5	secondary	secondary	JJ
cord-002209-xs6qigg4	11	6	to	to	IN
cord-002209-xs6qigg4	11	7	neurons	neuron	NNS
cord-002209-xs6qigg4	11	8	in	in	IN
cord-002209-xs6qigg4	11	9	central	central	JJ
cord-002209-xs6qigg4	11	10	nervous	nervous	JJ
cord-002209-xs6qigg4	11	11	system	system	NN
cord-002209-xs6qigg4	11	12	(	(	-LRB-
cord-002209-xs6qigg4	11	13	CNS	CNS	NNP
cord-002209-xs6qigg4	11	14	)	)	-RRB-
cord-002209-xs6qigg4	11	15	function	function	NN
cord-002209-xs6qigg4	11	16	,	,	,
cord-002209-xs6qigg4	11	17	and	and	CC
cord-002209-xs6qigg4	11	18	erroneously	erroneously	RB
cord-002209-xs6qigg4	11	19	dismissed	dismiss	VBD
cord-002209-xs6qigg4	11	20	as	as	IN
cord-002209-xs6qigg4	11	21	"	"	``
cord-002209-xs6qigg4	11	22	brain	brain	NN
cord-002209-xs6qigg4	11	23	glue	glue	NN
cord-002209-xs6qigg4	11	24	"	"	''
cord-002209-xs6qigg4	12	1	(	(	-LRB-
cord-002209-xs6qigg4	12	2	glia	glia	NNP
cord-002209-xs6qigg4	12	3	is	be	VBZ
cord-002209-xs6qigg4	12	4	the	the	DT
cord-002209-xs6qigg4	12	5	Greek	greek	JJ
cord-002209-xs6qigg4	12	6	term	term	NN
cord-002209-xs6qigg4	12	7	for	for	IN
cord-002209-xs6qigg4	12	8	glue	glue	NN
cord-002209-xs6qigg4	12	9	)	)	-RRB-
cord-002209-xs6qigg4	12	10	.	.	.
cord-002209-xs6qigg4	13	1	Research	research	NN
cord-002209-xs6qigg4	13	2	over	over	IN
cord-002209-xs6qigg4	13	3	the	the	DT
cord-002209-xs6qigg4	13	4	past	past	JJ
cord-002209-xs6qigg4	13	5	two	two	CD
cord-002209-xs6qigg4	13	6	decades	decade	NNS
cord-002209-xs6qigg4	13	7	,	,	,
cord-002209-xs6qigg4	13	8	however	however	RB
cord-002209-xs6qigg4	13	9	,	,	,
cord-002209-xs6qigg4	13	10	has	have	VBZ
cord-002209-xs6qigg4	13	11	shown	show	VBN
cord-002209-xs6qigg4	13	12	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	13	13	roles	role	NNS
cord-002209-xs6qigg4	13	14	extending	extend	VBG
cord-002209-xs6qigg4	13	15	to	to	IN
cord-002209-xs6qigg4	13	16	a	a	DT
cord-002209-xs6qigg4	13	17	range	range	NN
cord-002209-xs6qigg4	13	18	of	of	IN
cord-002209-xs6qigg4	13	19	brain	brain	NN
cord-002209-xs6qigg4	13	20	functions	function	NNS
cord-002209-xs6qigg4	13	21	far	far	RB
cord-002209-xs6qigg4	13	22	beyond	beyond	IN
cord-002209-xs6qigg4	13	23	basic	basic	JJ
cord-002209-xs6qigg4	13	24	physical	physical	JJ
cord-002209-xs6qigg4	13	25	and	and	CC
cord-002209-xs6qigg4	13	26	metabolic	metabolic	JJ
cord-002209-xs6qigg4	13	27	neuronal	neuronal	JJ
cord-002209-xs6qigg4	13	28	support	support	NN
cord-002209-xs6qigg4	13	29	(	(	-LRB-
cord-002209-xs6qigg4	13	30	Sofroniew	Sofroniew	NNP
cord-002209-xs6qigg4	13	31	and	and	CC
cord-002209-xs6qigg4	13	32	Vinters	Vinters	NNP
cord-002209-xs6qigg4	13	33	,	,	,
cord-002209-xs6qigg4	13	34	2010	2010	CD
cord-002209-xs6qigg4	13	35	)	)	-RRB-
cord-002209-xs6qigg4	13	36	.	.	.
cord-002209-xs6qigg4	14	1	Astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	14	2	regulation	regulation	NN
cord-002209-xs6qigg4	14	3	of	of	IN
cord-002209-xs6qigg4	14	4	myelination	myelination	NN
cord-002209-xs6qigg4	14	5	was	be	VBD
cord-002209-xs6qigg4	14	6	first	first	RB
cord-002209-xs6qigg4	14	7	hypothesised	hypothesise	VBN
cord-002209-xs6qigg4	14	8	by	by	IN
cord-002209-xs6qigg4	14	9	Műller	Műller	NNP
cord-002209-xs6qigg4	14	10	in	in	IN
cord-002209-xs6qigg4	14	11	1904	1904	CD
cord-002209-xs6qigg4	14	12	,	,	,
cord-002209-xs6qigg4	14	13	who	who	WP
cord-002209-xs6qigg4	14	14	claimed	claim	VBD
cord-002209-xs6qigg4	14	15	that	that	IN
cord-002209-xs6qigg4	14	16	the	the	DT
cord-002209-xs6qigg4	14	17	demyelinating	demyelinating	JJ
cord-002209-xs6qigg4	14	18	disease	disease	NN
cord-002209-xs6qigg4	14	19	,	,	,
cord-002209-xs6qigg4	14	20	Multiple	Multiple	NNP
cord-002209-xs6qigg4	14	21	Sclerosis	Sclerosis	NNP
cord-002209-xs6qigg4	14	22	(	(	-LRB-
cord-002209-xs6qigg4	14	23	MS	MS	NNP
cord-002209-xs6qigg4	14	24	)	)	-RRB-
cord-002209-xs6qigg4	14	25	,	,	,
cord-002209-xs6qigg4	14	26	was	be	VBD
cord-002209-xs6qigg4	14	27	rooted	root	VBN
cord-002209-xs6qigg4	14	28	in	in	IN
cord-002209-xs6qigg4	14	29	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	14	30	dysfunction	dysfunction	NN
cord-002209-xs6qigg4	14	31	(	(	-LRB-
cord-002209-xs6qigg4	14	32	Müller	Müller	NNP
cord-002209-xs6qigg4	14	33	,	,	,
cord-002209-xs6qigg4	14	34	1904	1904	CD
cord-002209-xs6qigg4	14	35	;	;	:
cord-002209-xs6qigg4	14	36	Williams	Williams	NNP
cord-002209-xs6qigg4	14	37	et	et	NNP
cord-002209-xs6qigg4	14	38	al	al	NNP
cord-002209-xs6qigg4	14	39	.	.	NNP
cord-002209-xs6qigg4	14	40	,	,	,
cord-002209-xs6qigg4	14	41	2007	2007	CD
cord-002209-xs6qigg4	14	42	)	)	-RRB-
cord-002209-xs6qigg4	14	43	.	.	.
cord-002209-xs6qigg4	15	1	Evidence	evidence	NN
cord-002209-xs6qigg4	15	2	has	have	VBZ
cord-002209-xs6qigg4	15	3	since	since	IN
cord-002209-xs6qigg4	15	4	continued	continue	VBN
cord-002209-xs6qigg4	15	5	to	to	TO
cord-002209-xs6qigg4	15	6	grow	grow	VB
cord-002209-xs6qigg4	15	7	supporting	support	VBG
cord-002209-xs6qigg4	15	8	the	the	DT
cord-002209-xs6qigg4	15	9	premise	premise	NN
cord-002209-xs6qigg4	15	10	that	that	IN
cord-002209-xs6qigg4	15	11	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	15	12	could	could	MD
cord-002209-xs6qigg4	15	13	be	be	VB
cord-002209-xs6qigg4	15	14	important	important	JJ
cord-002209-xs6qigg4	15	15	in	in	IN
cord-002209-xs6qigg4	15	16	regulating	regulate	VBG
cord-002209-xs6qigg4	15	17	myelination	myelination	NN
cord-002209-xs6qigg4	15	18	(	(	-LRB-
cord-002209-xs6qigg4	15	19	Sofroniew	Sofroniew	NNP
cord-002209-xs6qigg4	15	20	and	and	CC
cord-002209-xs6qigg4	15	21	Vinters	Vinters	NNP
cord-002209-xs6qigg4	15	22	,	,	,
cord-002209-xs6qigg4	15	23	2010	2010	CD
cord-002209-xs6qigg4	15	24	;	;	:
cord-002209-xs6qigg4	15	25	Williams	Williams	NNP
cord-002209-xs6qigg4	15	26	et	et	NNP
cord-002209-xs6qigg4	15	27	al	al	NNP
cord-002209-xs6qigg4	15	28	.	.	NNP
cord-002209-xs6qigg4	15	29	,	,	,
cord-002209-xs6qigg4	15	30	2007	2007	CD
cord-002209-xs6qigg4	15	31	;	;	:
cord-002209-xs6qigg4	15	32	Barnett	Barnett	NNP
cord-002209-xs6qigg4	15	33	and	and	CC
cord-002209-xs6qigg4	15	34	Linington	Linington	NNP
cord-002209-xs6qigg4	15	35	,	,	,
cord-002209-xs6qigg4	15	36	2013	2013	CD
cord-002209-xs6qigg4	15	37	;	;	:
cord-002209-xs6qigg4	15	38	Moore	Moore	NNP
cord-002209-xs6qigg4	15	39	et	et	NNP
cord-002209-xs6qigg4	15	40	al	al	NNP
cord-002209-xs6qigg4	15	41	.	.	NNP
cord-002209-xs6qigg4	15	42	,	,	,
cord-002209-xs6qigg4	15	43	2011	2011	CD
cord-002209-xs6qigg4	15	44	)	)	-RRB-
cord-002209-xs6qigg4	15	45	.	.	.
cord-002209-xs6qigg4	16	1	Glial	glial	JJ
cord-002209-xs6qigg4	16	2	fibrillary	fibrillary	JJ
cord-002209-xs6qigg4	16	3	acidic	acidic	JJ
cord-002209-xs6qigg4	16	4	protein	protein	NN
cord-002209-xs6qigg4	16	5	(	(	-LRB-
cord-002209-xs6qigg4	16	6	GFAP	GFAP	NNP
cord-002209-xs6qigg4	16	7	)	)	-RRB-
cord-002209-xs6qigg4	16	8	has	have	VBZ
cord-002209-xs6qigg4	16	9	been	be	VBN
cord-002209-xs6qigg4	16	10	used	use	VBN
cord-002209-xs6qigg4	16	11	extensively	extensively	RB
cord-002209-xs6qigg4	16	12	in	in	IN
cord-002209-xs6qigg4	16	13	the	the	DT
cord-002209-xs6qigg4	16	14	study	study	NN
cord-002209-xs6qigg4	16	15	of	of	IN
cord-002209-xs6qigg4	16	16	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	16	17	.	.	.
cord-002209-xs6qigg4	17	1	Increased	increase	VBN
cord-002209-xs6qigg4	17	2	GFAP	GFAP	NNP
cord-002209-xs6qigg4	17	3	expression	expression	NN
cord-002209-xs6qigg4	17	4	has	have	VBZ
cord-002209-xs6qigg4	17	5	been	be	VBN
cord-002209-xs6qigg4	17	6	associated	associate	VBN
cord-002209-xs6qigg4	17	7	with	with	IN
cord-002209-xs6qigg4	17	8	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	17	9	reactivity	reactivity	NN
cord-002209-xs6qigg4	17	10	in	in	IN
cord-002209-xs6qigg4	17	11	CNS	CNS	NNP
cord-002209-xs6qigg4	17	12	lesions	lesion	NNS
cord-002209-xs6qigg4	17	13	and	and	CC
cord-002209-xs6qigg4	17	14	is	be	VBZ
cord-002209-xs6qigg4	17	15	a	a	DT
cord-002209-xs6qigg4	17	16	pathological	pathological	JJ
cord-002209-xs6qigg4	17	17	hallmark	hallmark	NN
cord-002209-xs6qigg4	17	18	of	of	IN
cord-002209-xs6qigg4	17	19	disease	disease	NN
cord-002209-xs6qigg4	17	20	and/or	and/or	CC
cord-002209-xs6qigg4	17	21	injury	injury	NN
cord-002209-xs6qigg4	17	22	.	.	.
cord-002209-xs6qigg4	18	1	Fig	Fig	NNP
cord-002209-xs6qigg4	18	2	.	.	.
cord-002209-xs6qigg4	19	1	1	1	CD
cord-002209-xs6qigg4	19	2	illustrates	illustrate	VBZ
cord-002209-xs6qigg4	19	3	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	19	4	immunolabelled	immunolabelle	VBN
cord-002209-xs6qigg4	19	5	with	with	IN
cord-002209-xs6qigg4	19	6	GFAP	GFAP	NNP
cord-002209-xs6qigg4	19	7	and	and	CC
cord-002209-xs6qigg4	19	8	nestin	nestin	NNP
cord-002209-xs6qigg4	19	9	,	,	,
cord-002209-xs6qigg4	19	10	another	another	DT
cord-002209-xs6qigg4	19	11	marker	marker	NN
cord-002209-xs6qigg4	19	12	thought	think	VBN
cord-002209-xs6qigg4	19	13	to	to	TO
cord-002209-xs6qigg4	19	14	label	label	VB
cord-002209-xs6qigg4	19	15	reactive	reactive	JJ
cord-002209-xs6qigg4	19	16	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	19	17	(	(	-LRB-
cord-002209-xs6qigg4	20	1	Kamphuis	Kamphuis	NNP
cord-002209-xs6qigg4	20	2	et	et	NNP
cord-002209-xs6qigg4	20	3	al	al	NNP
cord-002209-xs6qigg4	20	4	.	.	NNP
cord-002209-xs6qigg4	20	5	,	,	,
cord-002209-xs6qigg4	20	6	2012	2012	CD
cord-002209-xs6qigg4	20	7	)	)	-RRB-
cord-002209-xs6qigg4	20	8	.	.	.
cord-002209-xs6qigg4	21	1	In	in	IN
cord-002209-xs6qigg4	21	2	experimental	experimental	JJ
cord-002209-xs6qigg4	21	3	allergic	allergic	JJ
cord-002209-xs6qigg4	21	4	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	21	5	(	(	-LRB-
cord-002209-xs6qigg4	21	6	EAE	EAE	NNP
cord-002209-xs6qigg4	21	7	)	)	-RRB-
cord-002209-xs6qigg4	21	8	,	,	,
cord-002209-xs6qigg4	21	9	a	a	DT
cord-002209-xs6qigg4	21	10	widely	widely	RB
cord-002209-xs6qigg4	21	11	used	use	VBN
cord-002209-xs6qigg4	21	12	animal	animal	NN
cord-002209-xs6qigg4	21	13	model	model	NN
cord-002209-xs6qigg4	21	14	of	of	IN
cord-002209-xs6qigg4	21	15	MS	MS	NNP
cord-002209-xs6qigg4	21	16	,	,	,
cord-002209-xs6qigg4	21	17	where	where	WRB
cord-002209-xs6qigg4	21	18	demyelination	demyelination	NN
cord-002209-xs6qigg4	21	19	is	be	VBZ
cord-002209-xs6qigg4	21	20	induced	induce	VBN
cord-002209-xs6qigg4	21	21	by	by	IN
cord-002209-xs6qigg4	21	22	myelin	myelin	NN
cord-002209-xs6qigg4	21	23	antigens	antigen	NNS
cord-002209-xs6qigg4	21	24	,	,	,
cord-002209-xs6qigg4	21	25	administered	administer	VBN
cord-002209-xs6qigg4	21	26	together	together	RB
cord-002209-xs6qigg4	21	27	with	with	IN
cord-002209-xs6qigg4	21	28	adjuvant	adjuvant	NN
cord-002209-xs6qigg4	21	29	that	that	WDT
cord-002209-xs6qigg4	21	30	contains	contain	VBZ
cord-002209-xs6qigg4	21	31	bacterial	bacterial	JJ
cord-002209-xs6qigg4	21	32	components	component	NNS
cord-002209-xs6qigg4	21	33	(	(	-LRB-
cord-002209-xs6qigg4	21	34	Traugott	Traugott	NNP
cord-002209-xs6qigg4	21	35	and	and	CC
cord-002209-xs6qigg4	21	36	Lebon	Lebon	NNP
cord-002209-xs6qigg4	21	37	,	,	,
cord-002209-xs6qigg4	21	38	1988	1988	CD
cord-002209-xs6qigg4	21	39	;	;	:
cord-002209-xs6qigg4	21	40	Tsukada	Tsukada	NNP
cord-002209-xs6qigg4	21	41	et	et	NNP
cord-002209-xs6qigg4	21	42	al	al	NNP
cord-002209-xs6qigg4	21	43	.	.	NNP
cord-002209-xs6qigg4	21	44	,	,	,
cord-002209-xs6qigg4	21	45	1991	1991	CD
cord-002209-xs6qigg4	21	46	;	;	:
cord-002209-xs6qigg4	21	47	Villarroya	Villarroya	NNP
cord-002209-xs6qigg4	21	48	et	et	NNP
cord-002209-xs6qigg4	21	49	al	al	NNP
cord-002209-xs6qigg4	21	50	.	.	NNP
cord-002209-xs6qigg4	21	51	,	,	,
cord-002209-xs6qigg4	21	52	1996	1996	CD
cord-002209-xs6qigg4	21	53	)	)	-RRB-
cord-002209-xs6qigg4	21	54	,	,	,
cord-002209-xs6qigg4	21	55	GFAP	GFAP	NNP
cord-002209-xs6qigg4	21	56	expression	expression	NN
cord-002209-xs6qigg4	21	57	was	be	VBD
cord-002209-xs6qigg4	21	58	seen	see	VBN
cord-002209-xs6qigg4	21	59	on	on	IN
cord-002209-xs6qigg4	21	60	more	more	RBR
cord-002209-xs6qigg4	21	61	numerous	numerous	JJ
cord-002209-xs6qigg4	21	62	and	and	CC
cord-002209-xs6qigg4	21	63	much	much	RB
cord-002209-xs6qigg4	21	64	larger	large	JJR
cord-002209-xs6qigg4	21	65	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	21	66	processes	process	NNS
cord-002209-xs6qigg4	21	67	in	in	IN
cord-002209-xs6qigg4	21	68	chronic	chronic	JJ
cord-002209-xs6qigg4	21	69	lesions	lesion	NNS
cord-002209-xs6qigg4	21	70	compared	compare	VBN
cord-002209-xs6qigg4	21	71	to	to	IN
cord-002209-xs6qigg4	21	72	normal	normal	JJ
cord-002209-xs6qigg4	21	73	appearing	appear	VBG
cord-002209-xs6qigg4	21	74	white	white	JJ
cord-002209-xs6qigg4	21	75	matter	matter	NN
cord-002209-xs6qigg4	21	76	(	(	-LRB-
cord-002209-xs6qigg4	21	77	Webster	Webster	NNP
cord-002209-xs6qigg4	21	78	et	et	NNP
cord-002209-xs6qigg4	21	79	al	al	NNP
cord-002209-xs6qigg4	21	80	.	.	NNP
cord-002209-xs6qigg4	21	81	,	,	,
cord-002209-xs6qigg4	21	82	1985	1985	CD
cord-002209-xs6qigg4	21	83	;	;	:
cord-002209-xs6qigg4	21	84	Eng	Eng	NNP
cord-002209-xs6qigg4	21	85	et	et	NNP
cord-002209-xs6qigg4	21	86	al	al	NNP
cord-002209-xs6qigg4	21	87	.	.	NNP
cord-002209-xs6qigg4	21	88	,	,	,
cord-002209-xs6qigg4	21	89	1971	1971	CD
cord-002209-xs6qigg4	21	90	)	)	-RRB-
cord-002209-xs6qigg4	21	91	.	.	.
cord-002209-xs6qigg4	22	1	Thus	thus	RB
cord-002209-xs6qigg4	22	2	,	,	,
cord-002209-xs6qigg4	22	3	the	the	DT
cord-002209-xs6qigg4	22	4	degree	degree	NN
cord-002209-xs6qigg4	22	5	of	of	IN
cord-002209-xs6qigg4	22	6	GFAP	GFAP	NNP
cord-002209-xs6qigg4	22	7	immunoreactivity	immunoreactivity	NN
cord-002209-xs6qigg4	22	8	appears	appear	VBZ
cord-002209-xs6qigg4	22	9	to	to	TO
cord-002209-xs6qigg4	22	10	reflect	reflect	VB
cord-002209-xs6qigg4	22	11	the	the	DT
cord-002209-xs6qigg4	22	12	level	level	NN
cord-002209-xs6qigg4	22	13	of	of	IN
cord-002209-xs6qigg4	22	14	reactive	reactive	JJ
cord-002209-xs6qigg4	22	15	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	22	16	.	.	.
cord-002209-xs6qigg4	23	1	This	this	DT
cord-002209-xs6qigg4	23	2	was	be	VBD
cord-002209-xs6qigg4	23	3	reviewed	review	VBN
cord-002209-xs6qigg4	23	4	in	in	IN
cord-002209-xs6qigg4	23	5	detail	detail	NN
cord-002209-xs6qigg4	23	6	by	by	IN
cord-002209-xs6qigg4	23	7	Sofroniew	Sofroniew	NNP
cord-002209-xs6qigg4	23	8	and	and	CC
cord-002209-xs6qigg4	23	9	Vinters	Vinters	NNP
cord-002209-xs6qigg4	23	10	(	(	-LRB-
cord-002209-xs6qigg4	23	11	2010	2010	CD
cord-002209-xs6qigg4	23	12	)	)	-RRB-
cord-002209-xs6qigg4	23	13	,	,	,
cord-002209-xs6qigg4	23	14	who	who	WP
cord-002209-xs6qigg4	23	15	described	describe	VBD
cord-002209-xs6qigg4	23	16	a	a	DT
cord-002209-xs6qigg4	23	17	continuum	continuum	NN
cord-002209-xs6qigg4	23	18	of	of	IN
cord-002209-xs6qigg4	23	19	phenotypic	phenotypic	JJ
cord-002209-xs6qigg4	23	20	changes	change	NNS
cord-002209-xs6qigg4	23	21	,	,	,
cord-002209-xs6qigg4	23	22	that	that	DT
cord-002209-xs6qigg4	23	23	range	range	VBP
cord-002209-xs6qigg4	23	24	from	from	IN
cord-002209-xs6qigg4	23	25	mild	mild	JJ
cord-002209-xs6qigg4	23	26	to	to	IN
cord-002209-xs6qigg4	23	27	severe	severe	JJ
cord-002209-xs6qigg4	23	28	,	,	,
cord-002209-xs6qigg4	23	29	the	the	DT
cord-002209-xs6qigg4	23	30	latter	latter	JJ
cord-002209-xs6qigg4	23	31	resulting	result	VBG
cord-002209-xs6qigg4	23	32	in	in	IN
cord-002209-xs6qigg4	23	33	glial	glial	JJ
cord-002209-xs6qigg4	23	34	scar	scar	NN
cord-002209-xs6qigg4	23	35	formation	formation	NN
cord-002209-xs6qigg4	23	36	(	(	-LRB-
cord-002209-xs6qigg4	23	37	Sofroniew	Sofroniew	NNP
cord-002209-xs6qigg4	23	38	and	and	CC
cord-002209-xs6qigg4	23	39	Vinters	Vinters	NNP
cord-002209-xs6qigg4	23	40	,	,	,
cord-002209-xs6qigg4	23	41	2010	2010	CD
cord-002209-xs6qigg4	23	42	;	;	.
cord-002209-xs6qigg4	24	1	Nash	Nash	NNP
cord-002209-xs6qigg4	24	2	et	et	NNP
cord-002209-xs6qigg4	24	3	al	al	NNP
cord-002209-xs6qigg4	24	4	.	.	NNP
cord-002209-xs6qigg4	24	5	,	,	,
cord-002209-xs6qigg4	24	6	2011a	2011a	CD
cord-002209-xs6qigg4	24	7	)	)	-RRB-
cord-002209-xs6qigg4	24	8	.	.	.
cord-002209-xs6qigg4	25	1	Attempts	attempt	NNS
cord-002209-xs6qigg4	25	2	have	have	VBP
cord-002209-xs6qigg4	25	3	also	also	RB
cord-002209-xs6qigg4	25	4	been	be	VBN
cord-002209-xs6qigg4	25	5	made	make	VBN
cord-002209-xs6qigg4	25	6	to	to	TO
cord-002209-xs6qigg4	25	7	define	define	VB
cord-002209-xs6qigg4	25	8	the	the	DT
cord-002209-xs6qigg4	25	9	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	25	10	phenotype	phenotype	NN
cord-002209-xs6qigg4	25	11	in	in	IN
cord-002209-xs6qigg4	25	12	more	more	JJR
cord-002209-xs6qigg4	25	13	detail	detail	NN
cord-002209-xs6qigg4	25	14	along	along	IN
cord-002209-xs6qigg4	25	15	this	this	DT
cord-002209-xs6qigg4	25	16	continuum	continuum	NN
cord-002209-xs6qigg4	26	1	(	(	-LRB-
cord-002209-xs6qigg4	26	2	Liberto	Liberto	NNP
cord-002209-xs6qigg4	26	3	et	et	NNP
cord-002209-xs6qigg4	26	4	al	al	NNP
cord-002209-xs6qigg4	26	5	.	.	NNP
cord-002209-xs6qigg4	26	6	,	,	,
cord-002209-xs6qigg4	26	7	2004	2004	CD
cord-002209-xs6qigg4	26	8	)	)	-RRB-
cord-002209-xs6qigg4	26	9	.	.	.
cord-002209-xs6qigg4	27	1	It	-PRON-	PRP
cord-002209-xs6qigg4	27	2	has	have	VBZ
cord-002209-xs6qigg4	27	3	been	be	VBN
cord-002209-xs6qigg4	27	4	suggested	suggest	VBN
cord-002209-xs6qigg4	27	5	that	that	IN
cord-002209-xs6qigg4	27	6	mild	mild	JJ
cord-002209-xs6qigg4	27	7	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	27	8	is	be	VBZ
cord-002209-xs6qigg4	27	9	associated	associate	VBN
cord-002209-xs6qigg4	27	10	with	with	IN
cord-002209-xs6qigg4	27	11	astrocyte	astrocyte	NN
cord-002209-xs6qigg4	27	12	"	"	``
cord-002209-xs6qigg4	27	13	activation	activation	NN
cord-002209-xs6qigg4	27	14	"	"	''
cord-002209-xs6qigg4	27	15	and	and	CC
cord-002209-xs6qigg4	27	16	severe	severe	JJ
cord-002209-xs6qigg4	27	17	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	27	18	is	be	VBZ
cord-002209-xs6qigg4	27	19	associated	associate	VBN
cord-002209-xs6qigg4	27	20	with	with	IN
cord-002209-xs6qigg4	27	21	"	"	``
cord-002209-xs6qigg4	27	22	reactivity	reactivity	NN
cord-002209-xs6qigg4	27	23	"	"	''
cord-002209-xs6qigg4	27	24	,	,	,
cord-002209-xs6qigg4	27	25	with	with	IN
cord-002209-xs6qigg4	27	26	the	the	DT
cord-002209-xs6qigg4	27	27	former	former	JJ
cord-002209-xs6qigg4	27	28	promoting	promote	VBG
cord-002209-xs6qigg4	27	29	recovery	recovery	NN
cord-002209-xs6qigg4	27	30	of	of	IN
cord-002209-xs6qigg4	27	31	CNS	CNS	NNP
cord-002209-xs6qigg4	27	32	function	function	NN
cord-002209-xs6qigg4	27	33	after	after	IN
cord-002209-xs6qigg4	27	34	injury	injury	NN
cord-002209-xs6qigg4	27	35	and	and	CC
cord-002209-xs6qigg4	27	36	the	the	DT
cord-002209-xs6qigg4	27	37	latter	latter	JJ
cord-002209-xs6qigg4	27	38	walling	wall	VBG
cord-002209-xs6qigg4	27	39	off	off	IN
cord-002209-xs6qigg4	27	40	the	the	DT
cord-002209-xs6qigg4	27	41	injured	injured	JJ
cord-002209-xs6qigg4	27	42	area	area	NN
cord-002209-xs6qigg4	27	43	and	and	CC
cord-002209-xs6qigg4	27	44	preventing	prevent	VBG
cord-002209-xs6qigg4	27	45	repair	repair	NN
cord-002209-xs6qigg4	28	1	(	(	-LRB-
cord-002209-xs6qigg4	28	2	Liberto	Liberto	NNP
cord-002209-xs6qigg4	28	3	et	et	NNP
cord-002209-xs6qigg4	28	4	al	al	NNP
cord-002209-xs6qigg4	28	5	.	.	NNP
cord-002209-xs6qigg4	28	6	,	,	,
cord-002209-xs6qigg4	28	7	2004	2004	CD
cord-002209-xs6qigg4	28	8	)	)	-RRB-
cord-002209-xs6qigg4	28	9	.	.	.
cord-002209-xs6qigg4	29	1	Although	although	IN
cord-002209-xs6qigg4	29	2	activated	activate	VBN
cord-002209-xs6qigg4	29	3	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	29	4	have	have	VBP
cord-002209-xs6qigg4	29	5	been	be	VBN
cord-002209-xs6qigg4	29	6	associated	associate	VBN
cord-002209-xs6qigg4	29	7	with	with	IN
cord-002209-xs6qigg4	29	8	less	less	RBR
cord-002209-xs6qigg4	29	9	detrimental	detrimental	JJ
cord-002209-xs6qigg4	29	10	effects	effect	NNS
cord-002209-xs6qigg4	29	11	on	on	IN
cord-002209-xs6qigg4	29	12	the	the	DT
cord-002209-xs6qigg4	29	13	CNS	CNS	NNP
cord-002209-xs6qigg4	29	14	and	and	CC
cord-002209-xs6qigg4	29	15	reactive	reactive	JJ
cord-002209-xs6qigg4	29	16	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	29	17	as	as	IN
cord-002209-xs6qigg4	29	18	more	more	RBR
cord-002209-xs6qigg4	29	19	damaging	damaging	JJ
cord-002209-xs6qigg4	29	20	,	,	,
cord-002209-xs6qigg4	29	21	it	-PRON-	PRP
cord-002209-xs6qigg4	29	22	is	be	VBZ
cord-002209-xs6qigg4	29	23	clear	clear	JJ
cord-002209-xs6qigg4	29	24	that	that	IN
cord-002209-xs6qigg4	29	25	these	these	DT
cord-002209-xs6qigg4	29	26	properties	property	NNS
cord-002209-xs6qigg4	29	27	are	be	VBP
cord-002209-xs6qigg4	29	28	not	not	RB
cord-002209-xs6qigg4	29	29	all	all	DT
cord-002209-xs6qigg4	29	30	or	or	CC
cord-002209-xs6qigg4	29	31	nothing	nothing	NN
cord-002209-xs6qigg4	29	32	and	and	CC
cord-002209-xs6qigg4	29	33	reactive	reactive	JJ
cord-002209-xs6qigg4	29	34	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	29	35	can	can	MD
cord-002209-xs6qigg4	29	36	Fig	Fig	NNP
cord-002209-xs6qigg4	29	37	.	.	.
cord-002209-xs6qigg4	30	1	1	1	LS
cord-002209-xs6qigg4	30	2	.	.	.
cord-002209-xs6qigg4	31	1	Expression	expression	NN
cord-002209-xs6qigg4	31	2	of	of	IN
cord-002209-xs6qigg4	31	3	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	31	4	reactivity	reactivity	NN
cord-002209-xs6qigg4	31	5	markers	marker	NNS
cord-002209-xs6qigg4	31	6	.	.	.
cord-002209-xs6qigg4	32	1	Rat	Rat	NNP
cord-002209-xs6qigg4	32	2	neurosphere	neurosphere	RB
cord-002209-xs6qigg4	32	3	-	-	HYPH
cord-002209-xs6qigg4	32	4	derived	derive	VBN
cord-002209-xs6qigg4	32	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	32	6	cultured	culture	VBN
cord-002209-xs6qigg4	32	7	on	on	IN
cord-002209-xs6qigg4	32	8	PLL	PLL	NNP
cord-002209-xs6qigg4	32	9	-	-	HYPH
cord-002209-xs6qigg4	32	10	coated	coated	JJ
cord-002209-xs6qigg4	32	11	glass	glass	NN
cord-002209-xs6qigg4	32	12	coverslips	coverslip	NNS
cord-002209-xs6qigg4	32	13	express	express	VBP
cord-002209-xs6qigg4	32	14	the	the	DT
cord-002209-xs6qigg4	32	15	reactivity	reactivity	NN
cord-002209-xs6qigg4	32	16	markers	marker	NNS
cord-002209-xs6qigg4	32	17	GFAP	GFAP	NNP
cord-002209-xs6qigg4	32	18	(	(	-LRB-
cord-002209-xs6qigg4	32	19	green	green	JJ
cord-002209-xs6qigg4	32	20	)	)	-RRB-
cord-002209-xs6qigg4	32	21	and	and	CC
cord-002209-xs6qigg4	32	22	nestin	nestin	NNP
cord-002209-xs6qigg4	32	23	(	(	-LRB-
cord-002209-xs6qigg4	32	24	red	red	NNP
cord-002209-xs6qigg4	32	25	)	)	-RRB-
cord-002209-xs6qigg4	32	26	.	.	.
cord-002209-xs6qigg4	33	1	Astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	33	2	effects	effect	NNS
cord-002209-xs6qigg4	33	3	on	on	IN
cord-002209-xs6qigg4	33	4	re	re	NN
cord-002209-xs6qigg4	33	5	/	/	NN
cord-002209-xs6qigg4	33	6	myelination	myelination	NN
cord-002209-xs6qigg4	33	7	can	can	MD
cord-002209-xs6qigg4	33	8	be	be	VB
cord-002209-xs6qigg4	33	9	classified	classify	VBN
cord-002209-xs6qigg4	33	10	into	into	IN
cord-002209-xs6qigg4	33	11	4	4	CD
cord-002209-xs6qigg4	33	12	main	main	JJ
cord-002209-xs6qigg4	33	13	groups	group	NNS
cord-002209-xs6qigg4	33	14	.	.	.
cord-002209-xs6qigg4	34	1	They	-PRON-	PRP
cord-002209-xs6qigg4	34	2	contribute	contribute	VBP
cord-002209-xs6qigg4	34	3	to	to	IN
cord-002209-xs6qigg4	34	4	re	re	NN
cord-002209-xs6qigg4	34	5	/	/	NN
cord-002209-xs6qigg4	34	6	myelination	myelination	NN
cord-002209-xs6qigg4	34	7	by	by	IN
cord-002209-xs6qigg4	35	1	:	:	:
cord-002209-xs6qigg4	35	2	1	1	LS
cord-002209-xs6qigg4	35	3	)	)	-RRB-
cord-002209-xs6qigg4	35	4	Providing	provide	VBG
cord-002209-xs6qigg4	35	5	an	an	DT
cord-002209-xs6qigg4	35	6	energy	energy	NN
cord-002209-xs6qigg4	35	7	source	source	NN
cord-002209-xs6qigg4	35	8	(	(	-LRB-
cord-002209-xs6qigg4	35	9	lactate	lactate	NN
cord-002209-xs6qigg4	35	10	)	)	-RRB-
cord-002209-xs6qigg4	35	11	and	and	CC
cord-002209-xs6qigg4	35	12	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	35	13	for	for	IN
cord-002209-xs6qigg4	35	14	neurons	neuron	NNS
cord-002209-xs6qigg4	35	15	.	.	.
cord-002209-xs6qigg4	36	1	Glucose	glucose	NN
cord-002209-xs6qigg4	36	2	taken	take	VBN
cord-002209-xs6qigg4	36	3	up	up	RP
cord-002209-xs6qigg4	36	4	by	by	IN
cord-002209-xs6qigg4	36	5	endothelial	endothelial	JJ
cord-002209-xs6qigg4	36	6	cells	cell	NNS
cord-002209-xs6qigg4	36	7	lining	line	VBG
cord-002209-xs6qigg4	36	8	the	the	DT
cord-002209-xs6qigg4	36	9	blood	blood	NN
cord-002209-xs6qigg4	36	10	brain	brain	NN
cord-002209-xs6qigg4	36	11	barrier	barrier	NN
cord-002209-xs6qigg4	36	12	is	be	VBZ
cord-002209-xs6qigg4	36	13	later	later	RB
cord-002209-xs6qigg4	36	14	transferred	transfer	VBN
cord-002209-xs6qigg4	36	15	to	to	IN
cord-002209-xs6qigg4	36	16	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	36	17	which	which	WDT
cord-002209-xs6qigg4	36	18	transform	transform	VBP
cord-002209-xs6qigg4	36	19	it	-PRON-	PRP
cord-002209-xs6qigg4	36	20	to	to	IN
cord-002209-xs6qigg4	36	21	glycogen	glycogen	NN
cord-002209-xs6qigg4	36	22	,	,	,
cord-002209-xs6qigg4	36	23	which	which	WDT
cord-002209-xs6qigg4	36	24	can	can	MD
cord-002209-xs6qigg4	36	25	then	then	RB
cord-002209-xs6qigg4	36	26	be	be	VB
cord-002209-xs6qigg4	36	27	used	use	VBN
cord-002209-xs6qigg4	36	28	to	to	TO
cord-002209-xs6qigg4	36	29	produce	produce	VB
cord-002209-xs6qigg4	36	30	lactate	lactate	NN
cord-002209-xs6qigg4	36	31	.	.	.
cord-002209-xs6qigg4	37	1	2	2	LS
cord-002209-xs6qigg4	37	2	)	)	-RRB-
cord-002209-xs6qigg4	37	3	Playing	play	VBG
cord-002209-xs6qigg4	37	4	a	a	DT
cord-002209-xs6qigg4	37	5	role	role	NN
cord-002209-xs6qigg4	37	6	in	in	IN
cord-002209-xs6qigg4	37	7	synaptic	synaptic	JJ
cord-002209-xs6qigg4	37	8	signal	signal	NN
cord-002209-xs6qigg4	37	9	transmission	transmission	NN
cord-002209-xs6qigg4	37	10	by	by	IN
cord-002209-xs6qigg4	37	11	regulating	regulate	VBG
cord-002209-xs6qigg4	37	12	the	the	DT
cord-002209-xs6qigg4	37	13	fluid	fluid	NN
cord-002209-xs6qigg4	37	14	,	,	,
cord-002209-xs6qigg4	37	15	pH	ph	NN
cord-002209-xs6qigg4	37	16	/	/	SYM
cord-002209-xs6qigg4	37	17	ion	ion	NN
cord-002209-xs6qigg4	37	18	(	(	-LRB-
cord-002209-xs6qigg4	37	19	e.g.	e.g.	RB
cord-002209-xs6qigg4	37	20	potassium	potassium	NN
cord-002209-xs6qigg4	37	21	,	,	,
cord-002209-xs6qigg4	37	22	K	K	NNP
cord-002209-xs6qigg4	37	23	+	+	SYM
cord-002209-xs6qigg4	37	24	)	)	-RRB-
cord-002209-xs6qigg4	37	25	,	,	,
cord-002209-xs6qigg4	37	26	glio	glio	NNP
cord-002209-xs6qigg4	37	27	/	/	SYM
cord-002209-xs6qigg4	37	28	neurotransmitter	neurotransmitter	NN
cord-002209-xs6qigg4	37	29	homeostasis	homeostasis	NN
cord-002209-xs6qigg4	37	30	and	and	CC
cord-002209-xs6qigg4	37	31	contributing	contribute	VBG
cord-002209-xs6qigg4	37	32	to	to	IN
cord-002209-xs6qigg4	37	33	synapse	synapse	NN
cord-002209-xs6qigg4	37	34	modulation	modulation	NN
cord-002209-xs6qigg4	37	35	through	through	IN
cord-002209-xs6qigg4	37	36	secreted	secrete	VBN
cord-002209-xs6qigg4	37	37	molecules	molecule	NNS
cord-002209-xs6qigg4	37	38	,	,	,
cord-002209-xs6qigg4	37	39	such	such	JJ
cord-002209-xs6qigg4	37	40	as	as	IN
cord-002209-xs6qigg4	37	41	thrombospondins	thrombospondin	NNS
cord-002209-xs6qigg4	37	42	(	(	-LRB-
cord-002209-xs6qigg4	37	43	THBSs	THBSs	NNP
cord-002209-xs6qigg4	37	44	)	)	-RRB-
cord-002209-xs6qigg4	37	45	.	.	.
cord-002209-xs6qigg4	38	1	3	3	LS
cord-002209-xs6qigg4	38	2	)	)	-RRB-
cord-002209-xs6qigg4	39	1	Affecting	affect	VBG
cord-002209-xs6qigg4	39	2	the	the	DT
cord-002209-xs6qigg4	39	3	survival	survival	NN
cord-002209-xs6qigg4	39	4	,	,	,
cord-002209-xs6qigg4	39	5	proliferation	proliferation	NN
cord-002209-xs6qigg4	39	6	and	and	CC
cord-002209-xs6qigg4	39	7	maturation	maturation	NN
cord-002209-xs6qigg4	39	8	of	of	IN
cord-002209-xs6qigg4	39	9	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	39	10	by	by	IN
cord-002209-xs6qigg4	39	11	secreting	secrete	VBG
cord-002209-xs6qigg4	39	12	growth	growth	NN
cord-002209-xs6qigg4	39	13	factors	factor	NNS
cord-002209-xs6qigg4	39	14	,	,	,
cord-002209-xs6qigg4	39	15	some	some	DT
cord-002209-xs6qigg4	39	16	of	of	IN
cord-002209-xs6qigg4	39	17	which	which	WDT
cord-002209-xs6qigg4	39	18	are	be	VBP
cord-002209-xs6qigg4	39	19	regulated	regulate	VBN
cord-002209-xs6qigg4	39	20	by	by	IN
cord-002209-xs6qigg4	39	21	iron	iron	NN
cord-002209-xs6qigg4	39	22	homeostasis	homeostasis	NN
cord-002209-xs6qigg4	39	23	provided	provide	VBN
cord-002209-xs6qigg4	39	24	by	by	IN
cord-002209-xs6qigg4	39	25	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	39	26	.	.	.
cord-002209-xs6qigg4	40	1	Chemokines	Chemokines	NNPS
cord-002209-xs6qigg4	40	2	may	may	MD
cord-002209-xs6qigg4	40	3	also	also	RB
cord-002209-xs6qigg4	40	4	influence	influence	VB
cord-002209-xs6qigg4	40	5	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	40	6	membrane	membrane	NNP
cord-002209-xs6qigg4	40	7	ensheathment	ensheathment	NN
cord-002209-xs6qigg4	40	8	of	of	IN
cord-002209-xs6qigg4	40	9	axons	axon	NNS
cord-002209-xs6qigg4	40	10	.	.	.
cord-002209-xs6qigg4	41	1	4	4	LS
cord-002209-xs6qigg4	41	2	)	)	-RRB-
cord-002209-xs6qigg4	41	3	Altering	alter	VBG
cord-002209-xs6qigg4	41	4	reactivity	reactivity	NN
cord-002209-xs6qigg4	41	5	status	status	NN
cord-002209-xs6qigg4	41	6	through	through	IN
cord-002209-xs6qigg4	41	7	their	-PRON-	PRP$
cord-002209-xs6qigg4	41	8	release	release	NN
cord-002209-xs6qigg4	41	9	of	of	IN
cord-002209-xs6qigg4	41	10	chemokines	chemokine	NNS
cord-002209-xs6qigg4	41	11	/	/	SYM
cord-002209-xs6qigg4	41	12	cytokines	cytokine	NNS
cord-002209-xs6qigg4	41	13	,	,	,
cord-002209-xs6qigg4	41	14	which	which	WDT
cord-002209-xs6qigg4	41	15	in	in	IN
cord-002209-xs6qigg4	41	16	turn	turn	NN
cord-002209-xs6qigg4	41	17	affects	affect	VBZ
cord-002209-xs6qigg4	41	18	the	the	DT
cord-002209-xs6qigg4	41	19	cross	cross	NN
cord-002209-xs6qigg4	41	20	-	-	NN
cord-002209-xs6qigg4	41	21	talk	talk	NN
cord-002209-xs6qigg4	41	22	between	between	IN
cord-002209-xs6qigg4	41	23	all	all	DT
cord-002209-xs6qigg4	41	24	neural	neural	JJ
cord-002209-xs6qigg4	41	25	cells	cell	NNS
cord-002209-xs6qigg4	41	26	including	include	VBG
cord-002209-xs6qigg4	41	27	microglia	microglia	NNS
cord-002209-xs6qigg4	41	28	.	.	.
cord-002209-xs6qigg4	42	1	also	also	RB
cord-002209-xs6qigg4	42	2	be	be	VB
cord-002209-xs6qigg4	42	3	beneficial	beneficial	JJ
cord-002209-xs6qigg4	42	4	to	to	IN
cord-002209-xs6qigg4	42	5	CNS	CNS	NNP
cord-002209-xs6qigg4	42	6	repair	repair	NN
cord-002209-xs6qigg4	42	7	.	.	.
cord-002209-xs6qigg4	43	1	Interestingly	interestingly	RB
cord-002209-xs6qigg4	43	2	,	,	,
cord-002209-xs6qigg4	43	3	in	in	IN
cord-002209-xs6qigg4	43	4	studies	study	NNS
cord-002209-xs6qigg4	43	5	using	use	VBG
cord-002209-xs6qigg4	43	6	GFAP	GFAP	NNP
cord-002209-xs6qigg4	43	7	null	null	JJ
cord-002209-xs6qigg4	43	8	mice	mouse	NNS
cord-002209-xs6qigg4	43	9	,	,	,
cord-002209-xs6qigg4	43	10	it	-PRON-	PRP
cord-002209-xs6qigg4	43	11	was	be	VBD
cord-002209-xs6qigg4	43	12	seen	see	VBN
cord-002209-xs6qigg4	43	13	that	that	IN
cord-002209-xs6qigg4	43	14	animals	animal	NNS
cord-002209-xs6qigg4	43	15	had	have	VBD
cord-002209-xs6qigg4	43	16	abnormal	abnormal	JJ
cord-002209-xs6qigg4	43	17	myelination	myelination	NN
cord-002209-xs6qigg4	43	18	,	,	,
cord-002209-xs6qigg4	43	19	nonmyelinated	nonmyelinated	NNP
cord-002209-xs6qigg4	43	20	axons	axon	NNS
cord-002209-xs6qigg4	43	21	in	in	IN
cord-002209-xs6qigg4	43	22	the	the	DT
cord-002209-xs6qigg4	43	23	optic	optic	JJ
cord-002209-xs6qigg4	43	24	nerve	nerve	NN
cord-002209-xs6qigg4	43	25	with	with	IN
cord-002209-xs6qigg4	43	26	an	an	DT
cord-002209-xs6qigg4	43	27	age	age	NN
cord-002209-xs6qigg4	43	28	related	relate	VBN
cord-002209-xs6qigg4	43	29	reduction	reduction	NN
cord-002209-xs6qigg4	43	30	in	in	IN
cord-002209-xs6qigg4	43	31	myelin	myelin	NN
cord-002209-xs6qigg4	43	32	thickness	thickness	NN
cord-002209-xs6qigg4	44	1	(	(	-LRB-
cord-002209-xs6qigg4	44	2	Liedtke	Liedtke	NNP
cord-002209-xs6qigg4	44	3	et	et	NNP
cord-002209-xs6qigg4	44	4	al	al	NNP
cord-002209-xs6qigg4	44	5	.	.	NNP
cord-002209-xs6qigg4	44	6	,	,	,
cord-002209-xs6qigg4	44	7	1996	1996	CD
cord-002209-xs6qigg4	44	8	)	)	-RRB-
cord-002209-xs6qigg4	44	9	.	.	.
cord-002209-xs6qigg4	45	1	Non	non	JJ
cord-002209-xs6qigg4	45	2	-	-	JJ
cord-002209-xs6qigg4	45	3	conservative	conservative	JJ
cord-002209-xs6qigg4	45	4	mutations	mutation	NNS
cord-002209-xs6qigg4	45	5	in	in	IN
cord-002209-xs6qigg4	45	6	the	the	DT
cord-002209-xs6qigg4	45	7	GFAP	GFAP	NNP
cord-002209-xs6qigg4	45	8	gene	gene	NN
cord-002209-xs6qigg4	45	9	have	have	VBP
cord-002209-xs6qigg4	45	10	also	also	RB
cord-002209-xs6qigg4	45	11	been	be	VBN
cord-002209-xs6qigg4	45	12	linked	link	VBN
cord-002209-xs6qigg4	45	13	to	to	IN
cord-002209-xs6qigg4	45	14	the	the	DT
cord-002209-xs6qigg4	45	15	white	white	JJ
cord-002209-xs6qigg4	45	16	matter	matter	NN
cord-002209-xs6qigg4	45	17	brain	brain	NN
cord-002209-xs6qigg4	45	18	disorder	disorder	NN
cord-002209-xs6qigg4	45	19	,	,	,
cord-002209-xs6qigg4	45	20	Alexander	Alexander	NNP
cord-002209-xs6qigg4	45	21	disease	disease	NN
cord-002209-xs6qigg4	45	22	(	(	-LRB-
cord-002209-xs6qigg4	45	23	Brenner	Brenner	NNP
cord-002209-xs6qigg4	45	24	et	et	NNP
cord-002209-xs6qigg4	45	25	al	al	NNP
cord-002209-xs6qigg4	45	26	.	.	NNP
cord-002209-xs6qigg4	45	27	,	,	,
cord-002209-xs6qigg4	45	28	2001	2001	CD
cord-002209-xs6qigg4	45	29	;	;	:
cord-002209-xs6qigg4	45	30	Li	Li	NNP
cord-002209-xs6qigg4	45	31	et	et	NNP
cord-002209-xs6qigg4	45	32	al	al	NNP
cord-002209-xs6qigg4	45	33	.	.	NNP
cord-002209-xs6qigg4	45	34	,	,	,
cord-002209-xs6qigg4	45	35	2002	2002	CD
cord-002209-xs6qigg4	45	36	)	)	-RRB-
cord-002209-xs6qigg4	45	37	.	.	.
cord-002209-xs6qigg4	46	1	Therefore	therefore	RB
cord-002209-xs6qigg4	46	2	,	,	,
cord-002209-xs6qigg4	46	3	the	the	DT
cord-002209-xs6qigg4	46	4	evidence	evidence	NN
cord-002209-xs6qigg4	46	5	for	for	IN
cord-002209-xs6qigg4	46	6	direct	direct	JJ
cord-002209-xs6qigg4	46	7	or	or	CC
cord-002209-xs6qigg4	46	8	indirect	indirect	JJ
cord-002209-xs6qigg4	46	9	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	46	10	roles	role	NNS
cord-002209-xs6qigg4	46	11	on	on	IN
cord-002209-xs6qigg4	46	12	re	re	NN
cord-002209-xs6qigg4	46	13	/	/	NN
cord-002209-xs6qigg4	46	14	myelination	myelination	NN
cord-002209-xs6qigg4	46	15	has	have	VBZ
cord-002209-xs6qigg4	46	16	been	be	VBN
cord-002209-xs6qigg4	46	17	established	establish	VBN
cord-002209-xs6qigg4	46	18	both	both	CC
cord-002209-xs6qigg4	46	19	by	by	IN
cord-002209-xs6qigg4	46	20	in	in	FW
cord-002209-xs6qigg4	46	21	vitro	vitro	FW
cord-002209-xs6qigg4	46	22	and	and	CC
cord-002209-xs6qigg4	46	23	in	in	IN
cord-002209-xs6qigg4	46	24	vivo	vivo	NNP
cord-002209-xs6qigg4	46	25	studies	study	NNS
cord-002209-xs6qigg4	46	26	.	.	.
cord-002209-xs6qigg4	47	1	Considering	consider	VBG
cord-002209-xs6qigg4	47	2	the	the	DT
cord-002209-xs6qigg4	47	3	limitations	limitation	NNS
cord-002209-xs6qigg4	47	4	in	in	IN
cord-002209-xs6qigg4	47	5	the	the	DT
cord-002209-xs6qigg4	47	6	current	current	JJ
cord-002209-xs6qigg4	47	7	treatments	treatment	NNS
cord-002209-xs6qigg4	47	8	for	for	IN
cord-002209-xs6qigg4	47	9	demyelinating	demyelinate	VBG
cord-002209-xs6qigg4	47	10	CNS	cns	JJ
cord-002209-xs6qigg4	47	11	diseases	disease	NNS
cord-002209-xs6qigg4	47	12	and	and	CC
cord-002209-xs6qigg4	47	13	injuries	injury	NNS
cord-002209-xs6qigg4	47	14	,	,	,
cord-002209-xs6qigg4	47	15	it	-PRON-	PRP
cord-002209-xs6qigg4	47	16	is	be	VBZ
cord-002209-xs6qigg4	47	17	crucial	crucial	JJ
cord-002209-xs6qigg4	47	18	to	to	TO
cord-002209-xs6qigg4	47	19	identify	identify	VB
cord-002209-xs6qigg4	47	20	other	other	JJ
cord-002209-xs6qigg4	47	21	approaches	approach	NNS
cord-002209-xs6qigg4	47	22	to	to	TO
cord-002209-xs6qigg4	47	23	regulate	regulate	VB
cord-002209-xs6qigg4	47	24	myelination	myelination	NN
cord-002209-xs6qigg4	47	25	in	in	IN
cord-002209-xs6qigg4	47	26	search	search	NN
cord-002209-xs6qigg4	47	27	of	of	IN
cord-002209-xs6qigg4	47	28	novel	novel	JJ
cord-002209-xs6qigg4	47	29	strategies	strategy	NNS
cord-002209-xs6qigg4	47	30	for	for	IN
cord-002209-xs6qigg4	47	31	repair	repair	NN
cord-002209-xs6qigg4	47	32	.	.	.
cord-002209-xs6qigg4	48	1	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	48	2	have	have	VBP
cord-002209-xs6qigg4	48	3	been	be	VBN
cord-002209-xs6qigg4	48	4	shown	show	VBN
cord-002209-xs6qigg4	48	5	to	to	TO
cord-002209-xs6qigg4	48	6	promote	promote	VB
cord-002209-xs6qigg4	48	7	myelination	myelination	NN
cord-002209-xs6qigg4	48	8	through	through	IN
cord-002209-xs6qigg4	48	9	their	-PRON-	PRP$
cord-002209-xs6qigg4	48	10	supportive	supportive	JJ
cord-002209-xs6qigg4	48	11	roles	role	NNS
cord-002209-xs6qigg4	48	12	on	on	IN
cord-002209-xs6qigg4	48	13	neuron	neuron	NN
cord-002209-xs6qigg4	48	14	survival	survival	NN
cord-002209-xs6qigg4	48	15	and	and	CC
cord-002209-xs6qigg4	48	16	maintenance	maintenance	NN
cord-002209-xs6qigg4	48	17	of	of	IN
cord-002209-xs6qigg4	48	18	neuronal	neuronal	JJ
cord-002209-xs6qigg4	48	19	activity	activity	NN
cord-002209-xs6qigg4	48	20	,	,	,
cord-002209-xs6qigg4	48	21	and	and	CC
cord-002209-xs6qigg4	48	22	their	-PRON-	PRP$
cord-002209-xs6qigg4	48	23	direct	direct	JJ
cord-002209-xs6qigg4	48	24	action	action	NN
cord-002209-xs6qigg4	48	25	on	on	IN
cord-002209-xs6qigg4	48	26	proliferation	proliferation	NN
cord-002209-xs6qigg4	48	27	,	,	,
cord-002209-xs6qigg4	48	28	differentiation	differentiation	NN
cord-002209-xs6qigg4	48	29	and	and	CC
cord-002209-xs6qigg4	48	30	migration	migration	NN
cord-002209-xs6qigg4	48	31	of	of	IN
cord-002209-xs6qigg4	48	32	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	48	33	(	(	-LRB-
cord-002209-xs6qigg4	48	34	Fig	Fig	NNP
cord-002209-xs6qigg4	48	35	.	.	NNP
cord-002209-xs6qigg4	48	36	2	2	CD
cord-002209-xs6qigg4	48	37	)	)	-RRB-
cord-002209-xs6qigg4	48	38	.	.	.
cord-002209-xs6qigg4	49	1	This	this	DT
cord-002209-xs6qigg4	49	2	review	review	NN
cord-002209-xs6qigg4	49	3	will	will	MD
cord-002209-xs6qigg4	49	4	focus	focus	VB
cord-002209-xs6qigg4	49	5	on	on	IN
cord-002209-xs6qigg4	49	6	the	the	DT
cord-002209-xs6qigg4	49	7	interaction	interaction	NN
cord-002209-xs6qigg4	49	8	of	of	IN
cord-002209-xs6qigg4	49	9	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	49	10	with	with	IN
cord-002209-xs6qigg4	49	11	neural	neural	JJ
cord-002209-xs6qigg4	49	12	cells	cell	NNS
cord-002209-xs6qigg4	49	13	to	to	TO
cord-002209-xs6qigg4	49	14	synergistically	synergistically	RB
cord-002209-xs6qigg4	49	15	promote	promote	VB
cord-002209-xs6qigg4	49	16	myelination	myelination	NN
cord-002209-xs6qigg4	49	17	.	.	.
cord-002209-xs6qigg4	50	1	It	-PRON-	PRP
cord-002209-xs6qigg4	50	2	is	be	VBZ
cord-002209-xs6qigg4	50	3	apparent	apparent	JJ
cord-002209-xs6qigg4	50	4	that	that	IN
cord-002209-xs6qigg4	50	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	50	6	can	can	MD
cord-002209-xs6qigg4	50	7	affect	affect	VB
cord-002209-xs6qigg4	50	8	myelination	myelination	NN
cord-002209-xs6qigg4	50	9	under	under	IN
cord-002209-xs6qigg4	50	10	a	a	DT
cord-002209-xs6qigg4	50	11	range	range	NN
cord-002209-xs6qigg4	50	12	of	of	IN
cord-002209-xs6qigg4	50	13	normal	normal	JJ
cord-002209-xs6qigg4	50	14	and	and	CC
cord-002209-xs6qigg4	50	15	pathological	pathological	JJ
cord-002209-xs6qigg4	50	16	conditions	condition	NNS
cord-002209-xs6qigg4	50	17	,	,	,
cord-002209-xs6qigg4	50	18	but	but	CC
cord-002209-xs6qigg4	50	19	it	-PRON-	PRP
cord-002209-xs6qigg4	50	20	is	be	VBZ
cord-002209-xs6qigg4	50	21	important	important	JJ
cord-002209-xs6qigg4	50	22	to	to	TO
cord-002209-xs6qigg4	50	23	understand	understand	VB
cord-002209-xs6qigg4	50	24	how	how	WRB
cord-002209-xs6qigg4	50	25	this	this	DT
cord-002209-xs6qigg4	50	26	is	be	VBZ
cord-002209-xs6qigg4	50	27	regulated	regulate	VBN
cord-002209-xs6qigg4	50	28	.	.	.
cord-002209-xs6qigg4	51	1	Many	many	JJ
cord-002209-xs6qigg4	51	2	molecules	molecule	NNS
cord-002209-xs6qigg4	51	3	can	can	MD
cord-002209-xs6qigg4	51	4	trigger	trigger	VB
cord-002209-xs6qigg4	51	5	or	or	CC
cord-002209-xs6qigg4	51	6	even	even	RB
cord-002209-xs6qigg4	51	7	regulate	regulate	VB
cord-002209-xs6qigg4	51	8	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	51	9	,	,	,
cord-002209-xs6qigg4	51	10	including	include	VBG
cord-002209-xs6qigg4	51	11	large	large	JJ
cord-002209-xs6qigg4	51	12	polypeptide	polypeptide	NN
cord-002209-xs6qigg4	51	13	growth	growth	NN
cord-002209-xs6qigg4	51	14	factors	factor	NNS
cord-002209-xs6qigg4	51	15	and	and	CC
cord-002209-xs6qigg4	51	16	cytokines	cytokine	NNS
cord-002209-xs6qigg4	51	17	(	(	-LRB-
cord-002209-xs6qigg4	51	18	John	John	NNP
cord-002209-xs6qigg4	51	19	et	et	NNP
cord-002209-xs6qigg4	51	20	al	al	NNP
cord-002209-xs6qigg4	51	21	.	.	NNP
cord-002209-xs6qigg4	51	22	,	,	,
cord-002209-xs6qigg4	51	23	2003	2003	CD
cord-002209-xs6qigg4	52	1	;	;	:
cord-002209-xs6qigg4	52	2	Moore	Moore	NNP
cord-002209-xs6qigg4	52	3	et	et	NNP
cord-002209-xs6qigg4	52	4	al	al	NNP
cord-002209-xs6qigg4	52	5	.	.	NNP
cord-002209-xs6qigg4	52	6	,	,	,
cord-002209-xs6qigg4	52	7	2011	2011	CD
cord-002209-xs6qigg4	52	8	)	)	-RRB-
cord-002209-xs6qigg4	52	9	,	,	,
cord-002209-xs6qigg4	52	10	mediators	mediator	NNS
cord-002209-xs6qigg4	52	11	of	of	IN
cord-002209-xs6qigg4	52	12	innate	innate	JJ
cord-002209-xs6qigg4	52	13	immunity	immunity	NN
cord-002209-xs6qigg4	52	14	such	such	JJ
cord-002209-xs6qigg4	52	15	as	as	IN
cord-002209-xs6qigg4	52	16	lipopolysaccharide	lipopolysaccharide	NN
cord-002209-xs6qigg4	52	17	(	(	-LRB-
cord-002209-xs6qigg4	52	18	LPS	LPS	NNP
cord-002209-xs6qigg4	52	19	)	)	-RRB-
cord-002209-xs6qigg4	52	20	and	and	CC
cord-002209-xs6qigg4	52	21	other	other	JJ
cord-002209-xs6qigg4	52	22	Toll	Toll	NNP
cord-002209-xs6qigg4	52	23	-	-	HYPH
cord-002209-xs6qigg4	52	24	like	like	JJ
cord-002209-xs6qigg4	52	25	receptor	receptor	NN
cord-002209-xs6qigg4	52	26	ligands	ligand	NNS
cord-002209-xs6qigg4	52	27	(	(	-LRB-
cord-002209-xs6qigg4	53	1	Farina	Farina	NNP
cord-002209-xs6qigg4	53	2	et	et	NNP
cord-002209-xs6qigg4	53	3	al	al	NNP
cord-002209-xs6qigg4	53	4	.	.	NNP
cord-002209-xs6qigg4	53	5	,	,	,
cord-002209-xs6qigg4	53	6	2007	2007	CD
cord-002209-xs6qigg4	53	7	)	)	-RRB-
cord-002209-xs6qigg4	53	8	,	,	,
cord-002209-xs6qigg4	53	9	neurotransmitters	neurotransmitter	NNS
cord-002209-xs6qigg4	53	10	(	(	-LRB-
cord-002209-xs6qigg4	53	11	Bekar	Bekar	NNP
cord-002209-xs6qigg4	53	12	et	et	FW
cord-002209-xs6qigg4	53	13	al	al	NNP
cord-002209-xs6qigg4	53	14	.	.	NNP
cord-002209-xs6qigg4	53	15	,	,	,
cord-002209-xs6qigg4	53	16	2008	2008	CD
cord-002209-xs6qigg4	53	17	)	)	-RRB-
cord-002209-xs6qigg4	53	18	,	,	,
cord-002209-xs6qigg4	53	19	purines	purine	NNS
cord-002209-xs6qigg4	53	20	,	,	,
cord-002209-xs6qigg4	53	21	reactive	reactive	JJ
cord-002209-xs6qigg4	53	22	oxygen	oxygen	NN
cord-002209-xs6qigg4	53	23	species	specie	NNS
cord-002209-xs6qigg4	53	24	,	,	,
cord-002209-xs6qigg4	53	25	and	and	CC
cord-002209-xs6qigg4	53	26	molecules	molecule	NNS
cord-002209-xs6qigg4	53	27	related	relate	VBN
cord-002209-xs6qigg4	53	28	to	to	IN
cord-002209-xs6qigg4	53	29	hypoxia	hypoxia	NN
cord-002209-xs6qigg4	53	30	and	and	CC
cord-002209-xs6qigg4	53	31	glucose	glucose	NN
cord-002209-xs6qigg4	53	32	deprivation	deprivation	NN
cord-002209-xs6qigg4	53	33	(	(	-LRB-
cord-002209-xs6qigg4	53	34	Swanson	Swanson	NNP
cord-002209-xs6qigg4	53	35	et	et	NNP
cord-002209-xs6qigg4	53	36	al	al	NNP
cord-002209-xs6qigg4	53	37	.	.	NNP
cord-002209-xs6qigg4	53	38	,	,	,
cord-002209-xs6qigg4	53	39	2004	2004	CD
cord-002209-xs6qigg4	53	40	)	)	-RRB-
cord-002209-xs6qigg4	53	41	.	.	.
cord-002209-xs6qigg4	54	1	For	for	IN
cord-002209-xs6qigg4	54	2	the	the	DT
cord-002209-xs6qigg4	54	3	purpose	purpose	NN
cord-002209-xs6qigg4	54	4	of	of	IN
cord-002209-xs6qigg4	54	5	this	this	DT
cord-002209-xs6qigg4	54	6	review	review	NN
cord-002209-xs6qigg4	54	7	we	-PRON-	PRP
cord-002209-xs6qigg4	54	8	will	will	MD
cord-002209-xs6qigg4	54	9	focus	focus	VB
cord-002209-xs6qigg4	54	10	on	on	IN
cord-002209-xs6qigg4	54	11	cytokines	cytokine	NNS
cord-002209-xs6qigg4	54	12	and	and	CC
cord-002209-xs6qigg4	54	13	chemokines	chemokine	NNS
cord-002209-xs6qigg4	54	14	.	.	.
cord-002209-xs6qigg4	55	1	Although	although	IN
cord-002209-xs6qigg4	55	2	these	these	DT
cord-002209-xs6qigg4	55	3	compounds	compound	NNS
cord-002209-xs6qigg4	55	4	are	be	VBP
cord-002209-xs6qigg4	55	5	primarily	primarily	RB
cord-002209-xs6qigg4	55	6	considered	consider	VBN
cord-002209-xs6qigg4	55	7	in	in	IN
cord-002209-xs6qigg4	55	8	the	the	DT
cord-002209-xs6qigg4	55	9	context	context	NN
cord-002209-xs6qigg4	55	10	of	of	IN
cord-002209-xs6qigg4	55	11	chemotaxis	chemotaxis	NN
cord-002209-xs6qigg4	55	12	in	in	IN
cord-002209-xs6qigg4	55	13	immune	immune	JJ
cord-002209-xs6qigg4	55	14	cells	cell	NNS
cord-002209-xs6qigg4	55	15	,	,	,
cord-002209-xs6qigg4	55	16	here	here	RB
cord-002209-xs6qigg4	55	17	we	-PRON-	PRP
cord-002209-xs6qigg4	55	18	will	will	MD
cord-002209-xs6qigg4	55	19	highlight	highlight	VB
cord-002209-xs6qigg4	55	20	their	-PRON-	PRP$
cord-002209-xs6qigg4	55	21	roles	role	NNS
cord-002209-xs6qigg4	55	22	on	on	IN
cord-002209-xs6qigg4	55	23	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	55	24	activation	activation	NN
cord-002209-xs6qigg4	55	25	and	and	CC
cord-002209-xs6qigg4	55	26	reactivity	reactivity	NN
cord-002209-xs6qigg4	55	27	.	.	.
cord-002209-xs6qigg4	56	1	These	these	DT
cord-002209-xs6qigg4	56	2	molecules	molecule	NNS
cord-002209-xs6qigg4	56	3	can	can	MD
cord-002209-xs6qigg4	56	4	be	be	VB
cord-002209-xs6qigg4	56	5	produced	produce	VBN
cord-002209-xs6qigg4	56	6	in	in	IN
cord-002209-xs6qigg4	56	7	an	an	DT
cord-002209-xs6qigg4	56	8	autocrine	autocrine	JJ
cord-002209-xs6qigg4	56	9	or	or	CC
cord-002209-xs6qigg4	56	10	paracrine	paracrine	JJ
cord-002209-xs6qigg4	56	11	fashion	fashion	NN
cord-002209-xs6qigg4	56	12	by	by	IN
cord-002209-xs6qigg4	56	13	various	various	JJ
cord-002209-xs6qigg4	56	14	cell	cell	NN
cord-002209-xs6qigg4	56	15	types	type	NNS
cord-002209-xs6qigg4	56	16	in	in	IN
cord-002209-xs6qigg4	56	17	the	the	DT
cord-002209-xs6qigg4	56	18	CNS	CNS	NNP
cord-002209-xs6qigg4	56	19	including	include	VBG
cord-002209-xs6qigg4	56	20	neurons	neuron	NNS
cord-002209-xs6qigg4	56	21	,	,	,
cord-002209-xs6qigg4	56	22	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	56	23	lineage	lineage	NN
cord-002209-xs6qigg4	56	24	cells	cell	NNS
cord-002209-xs6qigg4	56	25	,	,	,
cord-002209-xs6qigg4	56	26	microglia	microglia	NNS
cord-002209-xs6qigg4	56	27	,	,	,
cord-002209-xs6qigg4	56	28	pericytes	pericyte	NNS
cord-002209-xs6qigg4	56	29	and	and	CC
cord-002209-xs6qigg4	56	30	endothelial	endothelial	JJ
cord-002209-xs6qigg4	56	31	cells	cell	NNS
cord-002209-xs6qigg4	56	32	.	.	.
cord-002209-xs6qigg4	57	1	Not	not	RB
cord-002209-xs6qigg4	57	2	only	only	RB
cord-002209-xs6qigg4	57	3	do	do	VBP
cord-002209-xs6qigg4	57	4	these	these	DT
cord-002209-xs6qigg4	57	5	factors	factor	NNS
cord-002209-xs6qigg4	57	6	influence	influence	VB
cord-002209-xs6qigg4	57	7	astrocyte	astrocyte	DT
cord-002209-xs6qigg4	57	8	phenotype	phenotype	NN
cord-002209-xs6qigg4	58	1	but	but	CC
cord-002209-xs6qigg4	58	2	they	-PRON-	PRP
cord-002209-xs6qigg4	58	3	also	also	RB
cord-002209-xs6qigg4	58	4	can	can	MD
cord-002209-xs6qigg4	58	5	affect	affect	VB
cord-002209-xs6qigg4	58	6	a	a	DT
cord-002209-xs6qigg4	58	7	range	range	NN
cord-002209-xs6qigg4	58	8	of	of	IN
cord-002209-xs6qigg4	58	9	neural	neural	JJ
cord-002209-xs6qigg4	58	10	and	and	CC
cord-002209-xs6qigg4	58	11	immune	immune	JJ
cord-002209-xs6qigg4	58	12	cell	cell	NN
cord-002209-xs6qigg4	58	13	types	type	NNS
cord-002209-xs6qigg4	58	14	.	.	.
cord-002209-xs6qigg4	59	1	2.2	2.2	CD
cord-002209-xs6qigg4	59	2	.	.	.
cord-002209-xs6qigg4	60	1	Astrocyte	Astrocyte	NNP
cord-002209-xs6qigg4	60	2	activation	activation	NN
cord-002209-xs6qigg4	60	3	(	(	-LRB-
cord-002209-xs6qigg4	60	4	mild	mild	JJ
cord-002209-xs6qigg4	60	5	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	60	6	)	)	-RRB-
cord-002209-xs6qigg4	60	7	:	:	:
cord-002209-xs6qigg4	60	8	a	a	DT
cord-002209-xs6qigg4	60	9	pro	pro	JJ
cord-002209-xs6qigg4	60	10	-	-	JJ
cord-002209-xs6qigg4	60	11	reparative	reparative	JJ
cord-002209-xs6qigg4	60	12	phenotype	phenotype	NN
cord-002209-xs6qigg4	60	13	?	?	.
cord-002209-xs6qigg4	61	1	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	61	2	can	can	MD
cord-002209-xs6qigg4	61	3	be	be	VB
cord-002209-xs6qigg4	61	4	activated	activate	VBN
cord-002209-xs6qigg4	61	5	directly	directly	RB
cord-002209-xs6qigg4	61	6	or	or	CC
cord-002209-xs6qigg4	61	7	indirectly	indirectly	RB
cord-002209-xs6qigg4	61	8	.	.	.
cord-002209-xs6qigg4	62	1	For	for	IN
cord-002209-xs6qigg4	62	2	example	example	NN
cord-002209-xs6qigg4	62	3	,	,	,
cord-002209-xs6qigg4	62	4	in	in	IN
cord-002209-xs6qigg4	62	5	response	response	NN
cord-002209-xs6qigg4	62	6	to	to	IN
cord-002209-xs6qigg4	62	7	injury	injury	NN
cord-002209-xs6qigg4	62	8	,	,	,
cord-002209-xs6qigg4	62	9	microglia	microglia	NNP
cord-002209-xs6qigg4	62	10	become	become	VBP
cord-002209-xs6qigg4	62	11	activated	activate	VBN
cord-002209-xs6qigg4	62	12	and	and	CC
cord-002209-xs6qigg4	62	13	release	release	VB
cord-002209-xs6qigg4	62	14	the	the	DT
cord-002209-xs6qigg4	62	15	cytokine	cytokine	NN
cord-002209-xs6qigg4	62	16	interleukin	interleukin	NN
cord-002209-xs6qigg4	62	17	1β	1β	.
cord-002209-xs6qigg4	63	1	(	(	-LRB-
cord-002209-xs6qigg4	63	2	IL-1β	IL-1β	NNP
cord-002209-xs6qigg4	63	3	,	,	,
cord-002209-xs6qigg4	63	4	Herx	Herx	NNP
cord-002209-xs6qigg4	63	5	et	et	NNP
cord-002209-xs6qigg4	63	6	al	al	NNP
cord-002209-xs6qigg4	63	7	.	.	.
cord-002209-xs6qigg4	64	1	,	,	,
cord-002209-xs6qigg4	64	2	2000	2000	CD
cord-002209-xs6qigg4	64	3	)	)	-RRB-
cord-002209-xs6qigg4	64	4	,	,	,
cord-002209-xs6qigg4	64	5	which	which	WDT
cord-002209-xs6qigg4	64	6	is	be	VBZ
cord-002209-xs6qigg4	64	7	an	an	DT
cord-002209-xs6qigg4	64	8	early	early	JJ
cord-002209-xs6qigg4	64	9	injury	injury	NN
cord-002209-xs6qigg4	64	10	signal	signal	NN
cord-002209-xs6qigg4	64	11	(	(	-LRB-
cord-002209-xs6qigg4	64	12	Auron	Auron	NNP
cord-002209-xs6qigg4	64	13	,	,	,
cord-002209-xs6qigg4	64	14	1998	1998	CD
cord-002209-xs6qigg4	64	15	)	)	-RRB-
cord-002209-xs6qigg4	64	16	.	.	.
cord-002209-xs6qigg4	65	1	The	the	DT
cord-002209-xs6qigg4	65	2	delay	delay	NN
cord-002209-xs6qigg4	65	3	of	of	IN
cord-002209-xs6qigg4	65	4	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	65	5	activation	activation	NN
cord-002209-xs6qigg4	65	6	in	in	IN
cord-002209-xs6qigg4	65	7	mice	mouse	NNS
cord-002209-xs6qigg4	65	8	lacking	lack	VBG
cord-002209-xs6qigg4	65	9	IL-1β	il-1β	NN
cord-002209-xs6qigg4	65	10	,	,	,
cord-002209-xs6qigg4	65	11	as	as	RB
cord-002209-xs6qigg4	65	12	well	well	RB
cord-002209-xs6qigg4	65	13	as	as	IN
cord-002209-xs6qigg4	65	14	in	in	IN
cord-002209-xs6qigg4	65	15	mice	mouse	NNS
cord-002209-xs6qigg4	65	16	lacking	lack	VBG
cord-002209-xs6qigg4	65	17	IL-1	IL-1	NNP
cord-002209-xs6qigg4	65	18	type	type	NN
cord-002209-xs6qigg4	65	19	1	1	CD
cord-002209-xs6qigg4	65	20	receptor	receptor	NN
cord-002209-xs6qigg4	65	21	suggests	suggest	VBZ
cord-002209-xs6qigg4	65	22	that	that	IN
cord-002209-xs6qigg4	65	23	microglial	microglial	JJ
cord-002209-xs6qigg4	65	24	activation	activation	NN
cord-002209-xs6qigg4	65	25	is	be	VBZ
cord-002209-xs6qigg4	65	26	necessary	necessary	JJ
cord-002209-xs6qigg4	65	27	for	for	IN
cord-002209-xs6qigg4	65	28	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	65	29	activation	activation	NN
cord-002209-xs6qigg4	65	30	(	(	-LRB-
cord-002209-xs6qigg4	65	31	Herx	Herx	NNP
cord-002209-xs6qigg4	65	32	et	et	NNP
cord-002209-xs6qigg4	65	33	al	al	NNP
cord-002209-xs6qigg4	65	34	.	.	NNP
cord-002209-xs6qigg4	65	35	,	,	,
cord-002209-xs6qigg4	65	36	2000	2000	CD
cord-002209-xs6qigg4	65	37	)	)	-RRB-
cord-002209-xs6qigg4	65	38	.	.	.
cord-002209-xs6qigg4	66	1	It	-PRON-	PRP
cord-002209-xs6qigg4	66	2	has	have	VBZ
cord-002209-xs6qigg4	66	3	also	also	RB
cord-002209-xs6qigg4	66	4	been	be	VBN
cord-002209-xs6qigg4	66	5	suggested	suggest	VBN
cord-002209-xs6qigg4	66	6	that	that	IN
cord-002209-xs6qigg4	66	7	ciliary	ciliary	NN
cord-002209-xs6qigg4	66	8	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	66	9	factor	factor	NN
cord-002209-xs6qigg4	66	10	(	(	-LRB-
cord-002209-xs6qigg4	66	11	CNTF	CNTF	NNP
cord-002209-xs6qigg4	66	12	;	;	:
cord-002209-xs6qigg4	66	13	a	a	DT
cord-002209-xs6qigg4	66	14	member	member	NN
cord-002209-xs6qigg4	66	15	of	of	IN
cord-002209-xs6qigg4	66	16	the	the	DT
cord-002209-xs6qigg4	66	17	IL-6	IL-6	NNP
cord-002209-xs6qigg4	66	18	family	family	NN
cord-002209-xs6qigg4	66	19	of	of	IN
cord-002209-xs6qigg4	66	20	cytokines)treated	cytokines)treated	NNP
cord-002209-xs6qigg4	66	21	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	66	22	in	in	IN
cord-002209-xs6qigg4	66	23	vitro	vitro	FW
cord-002209-xs6qigg4	66	24	had	have	VBD
cord-002209-xs6qigg4	66	25	a	a	DT
cord-002209-xs6qigg4	66	26	phenotype	phenotype	NN
cord-002209-xs6qigg4	66	27	that	that	WDT
cord-002209-xs6qigg4	66	28	was	be	VBD
cord-002209-xs6qigg4	66	29	more	more	RBR
cord-002209-xs6qigg4	66	30	supportive	supportive	JJ
cord-002209-xs6qigg4	66	31	of	of	IN
cord-002209-xs6qigg4	66	32	CNS	CNS	NNP
cord-002209-xs6qigg4	66	33	repair	repair	NN
cord-002209-xs6qigg4	66	34	and	and	CC
cord-002209-xs6qigg4	66	35	thus	thus	RB
cord-002209-xs6qigg4	66	36	are	be	VBP
cord-002209-xs6qigg4	66	37	,	,	,
cord-002209-xs6qigg4	66	38	by	by	IN
cord-002209-xs6qigg4	66	39	definition	definition	NN
cord-002209-xs6qigg4	66	40	,	,	,
cord-002209-xs6qigg4	66	41	activated	activate	VBN
cord-002209-xs6qigg4	66	42	(	(	-LRB-
cord-002209-xs6qigg4	66	43	Albrecht	Albrecht	NNP
cord-002209-xs6qigg4	66	44	et	et	NNP
cord-002209-xs6qigg4	66	45	al	al	NNP
cord-002209-xs6qigg4	66	46	.	.	NNP
cord-002209-xs6qigg4	66	47	,	,	,
cord-002209-xs6qigg4	66	48	2002	2002	CD
cord-002209-xs6qigg4	66	49	;	;	:
cord-002209-xs6qigg4	66	50	.	.	.
cord-002209-xs6qigg4	67	1	Under	under	IN
cord-002209-xs6qigg4	67	2	CNTF	CNTF	NNP
cord-002209-xs6qigg4	67	3	treatment	treatment	NN
cord-002209-xs6qigg4	67	4	,	,	,
cord-002209-xs6qigg4	67	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	67	6	upregulate	upregulate	VBP
cord-002209-xs6qigg4	67	7	expression	expression	NN
cord-002209-xs6qigg4	67	8	of	of	IN
cord-002209-xs6qigg4	67	9	classical	classical	JJ
cord-002209-xs6qigg4	67	10	reactivity	reactivity	NN
cord-002209-xs6qigg4	67	11	markers	marker	NNS
cord-002209-xs6qigg4	67	12	such	such	JJ
cord-002209-xs6qigg4	67	13	as	as	IN
cord-002209-xs6qigg4	67	14	GFAP	GFAP	NNP
cord-002209-xs6qigg4	67	15	,	,	,
cord-002209-xs6qigg4	67	16	vimentin	vimentin	NNS
cord-002209-xs6qigg4	67	17	,	,	,
cord-002209-xs6qigg4	67	18	and	and	CC
cord-002209-xs6qigg4	67	19	clusterin	clusterin	NNP
cord-002209-xs6qigg4	67	20	,	,	,
cord-002209-xs6qigg4	67	21	show	show	VBP
cord-002209-xs6qigg4	67	22	cellular	cellular	JJ
cord-002209-xs6qigg4	67	23	and	and	CC
cord-002209-xs6qigg4	67	24	nuclear	nuclear	JJ
cord-002209-xs6qigg4	67	25	hypertrophy	hypertrophy	NN
cord-002209-xs6qigg4	67	26	,	,	,
cord-002209-xs6qigg4	67	27	and	and	CC
cord-002209-xs6qigg4	67	28	increase	increase	VB
cord-002209-xs6qigg4	67	29	their	-PRON-	PRP$
cord-002209-xs6qigg4	67	30	proliferation	proliferation	NN
cord-002209-xs6qigg4	67	31	rate	rate	NN
cord-002209-xs6qigg4	67	32	(	(	-LRB-
cord-002209-xs6qigg4	67	33	Winter	Winter	NNP
cord-002209-xs6qigg4	67	34	et	et	NNP
cord-002209-xs6qigg4	67	35	al	al	NNP
cord-002209-xs6qigg4	67	36	.	.	.
cord-002209-xs6qigg4	68	1	,	,	,
cord-002209-xs6qigg4	68	2	1995	1995	CD
cord-002209-xs6qigg4	68	3	;	;	:
cord-002209-xs6qigg4	68	4	Levison	Levison	NNP
cord-002209-xs6qigg4	68	5	et	et	NNP
cord-002209-xs6qigg4	68	6	al	al	NNP
cord-002209-xs6qigg4	68	7	.	.	NNP
cord-002209-xs6qigg4	68	8	,	,	,
cord-002209-xs6qigg4	68	9	1996	1996	CD
cord-002209-xs6qigg4	68	10	;	;	:
cord-002209-xs6qigg4	68	11	1998	1998	CD
cord-002209-xs6qigg4	68	12	;	;	:
cord-002209-xs6qigg4	69	1	Hudgins	Hudgins	NNP
cord-002209-xs6qigg4	69	2	and	and	CC
cord-002209-xs6qigg4	69	3	Levison	Levison	NNP
cord-002209-xs6qigg4	69	4	,	,	,
cord-002209-xs6qigg4	69	5	1998	1998	CD
cord-002209-xs6qigg4	69	6	)	)	-RRB-
cord-002209-xs6qigg4	69	7	.	.	.
cord-002209-xs6qigg4	70	1	There	there	EX
cord-002209-xs6qigg4	70	2	is	be	VBZ
cord-002209-xs6qigg4	70	3	a	a	DT
cord-002209-xs6qigg4	70	4	growing	grow	VBG
cord-002209-xs6qigg4	70	5	body	body	NN
cord-002209-xs6qigg4	70	6	of	of	IN
cord-002209-xs6qigg4	70	7	evidence	evidence	NN
cord-002209-xs6qigg4	70	8	for	for	IN
cord-002209-xs6qigg4	70	9	the	the	DT
cord-002209-xs6qigg4	70	10	promotion	promotion	NN
cord-002209-xs6qigg4	70	11	of	of	IN
cord-002209-xs6qigg4	70	12	neuronal	neuronal	JJ
cord-002209-xs6qigg4	70	13	survival	survival	NN
cord-002209-xs6qigg4	70	14	by	by	IN
cord-002209-xs6qigg4	70	15	cytokine	cytokine	NN
cord-002209-xs6qigg4	70	16	-	-	HYPH
cord-002209-xs6qigg4	70	17	activated	activate	VBN
cord-002209-xs6qigg4	70	18	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	70	19	,	,	,
cord-002209-xs6qigg4	70	20	potentially	potentially	RB
cord-002209-xs6qigg4	70	21	through	through	IN
cord-002209-xs6qigg4	70	22	secretion	secretion	NN
cord-002209-xs6qigg4	70	23	of	of	IN
cord-002209-xs6qigg4	70	24	various	various	JJ
cord-002209-xs6qigg4	70	25	neurotrophic	neurotrophic	JJ
cord-002209-xs6qigg4	70	26	growth	growth	NN
cord-002209-xs6qigg4	70	27	factors	factor	NNS
cord-002209-xs6qigg4	70	28	in	in	IN
cord-002209-xs6qigg4	70	29	the	the	DT
cord-002209-xs6qigg4	70	30	vicinity	vicinity	NN
cord-002209-xs6qigg4	70	31	of	of	IN
cord-002209-xs6qigg4	70	32	neurons	neuron	NNS
cord-002209-xs6qigg4	70	33	including	include	VBG
cord-002209-xs6qigg4	70	34	nerve	nerve	NN
cord-002209-xs6qigg4	70	35	Fig	Fig	NNP
cord-002209-xs6qigg4	70	36	.	.	.
cord-002209-xs6qigg4	70	37	3	3	CD
cord-002209-xs6qigg4	70	38	.	.	.
cord-002209-xs6qigg4	71	1	Simplified	simplify	VBN
cord-002209-xs6qigg4	71	2	schematic	schematic	NN
cord-002209-xs6qigg4	71	3	of	of	IN
cord-002209-xs6qigg4	71	4	the	the	DT
cord-002209-xs6qigg4	71	5	effects	effect	NNS
cord-002209-xs6qigg4	71	6	of	of	IN
cord-002209-xs6qigg4	71	7	cytokine	cytokine	NN
cord-002209-xs6qigg4	71	8	-	-	HYPH
cord-002209-xs6qigg4	71	9	activated	activate	VBN
cord-002209-xs6qigg4	71	10	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	71	11	on	on	IN
cord-002209-xs6qigg4	71	12	re	re	NN
cord-002209-xs6qigg4	71	13	/	/	NN
cord-002209-xs6qigg4	71	14	myelination	myelination	NN
cord-002209-xs6qigg4	71	15	.	.	.
cord-002209-xs6qigg4	72	1	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	72	2	can	can	MD
cord-002209-xs6qigg4	72	3	be	be	VB
cord-002209-xs6qigg4	72	4	influenced	influence	VBN
cord-002209-xs6qigg4	72	5	by	by	IN
cord-002209-xs6qigg4	72	6	various	various	JJ
cord-002209-xs6qigg4	72	7	cytokines	cytokine	NNS
cord-002209-xs6qigg4	72	8	to	to	TO
cord-002209-xs6qigg4	72	9	change	change	VB
cord-002209-xs6qigg4	72	10	their	-PRON-	PRP$
cord-002209-xs6qigg4	72	11	reactivity	reactivity	NN
cord-002209-xs6qigg4	72	12	status	status	NN
cord-002209-xs6qigg4	72	13	to	to	IN
cord-002209-xs6qigg4	72	14	one	one	CD
cord-002209-xs6qigg4	72	15	that	that	WDT
cord-002209-xs6qigg4	72	16	falls	fall	VBZ
cord-002209-xs6qigg4	72	17	within	within	IN
cord-002209-xs6qigg4	72	18	the	the	DT
cord-002209-xs6qigg4	72	19	continuum	continuum	NN
cord-002209-xs6qigg4	72	20	of	of	IN
cord-002209-xs6qigg4	72	21	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	72	22	,	,	,
cord-002209-xs6qigg4	72	23	namely	namely	RB
cord-002209-xs6qigg4	72	24	more	more	RBR
cord-002209-xs6qigg4	72	25	activated	activate	VBN
cord-002209-xs6qigg4	72	26	or	or	CC
cord-002209-xs6qigg4	72	27	reactive	reactive	JJ
cord-002209-xs6qigg4	72	28	;	;	:
cord-002209-xs6qigg4	72	29	both	both	DT
cord-002209-xs6qigg4	72	30	of	of	IN
cord-002209-xs6qigg4	72	31	which	which	WDT
cord-002209-xs6qigg4	72	32	will	will	MD
cord-002209-xs6qigg4	72	33	secrete	secrete	VB
cord-002209-xs6qigg4	72	34	factors	factor	NNS
cord-002209-xs6qigg4	72	35	that	that	WDT
cord-002209-xs6qigg4	72	36	can	can	MD
cord-002209-xs6qigg4	72	37	modulate	modulate	VB
cord-002209-xs6qigg4	72	38	myelination	myelination	NN
cord-002209-xs6qigg4	72	39	in	in	IN
cord-002209-xs6qigg4	72	40	a	a	DT
cord-002209-xs6qigg4	72	41	positive	positive	JJ
cord-002209-xs6qigg4	72	42	or	or	CC
cord-002209-xs6qigg4	72	43	negative	negative	JJ
cord-002209-xs6qigg4	72	44	way	way	NN
cord-002209-xs6qigg4	72	45	.	.	.
cord-002209-xs6qigg4	73	1	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	73	2	with	with	IN
cord-002209-xs6qigg4	73	3	more	more	RBR
cord-002209-xs6qigg4	73	4	severe	severe	JJ
cord-002209-xs6qigg4	73	5	reactivity	reactivity	NN
cord-002209-xs6qigg4	73	6	present	present	NN
cord-002209-xs6qigg4	73	7	increased	increase	VBD
cord-002209-xs6qigg4	73	8	GFAP	GFAP	NNP
cord-002209-xs6qigg4	73	9	expression	expression	NN
cord-002209-xs6qigg4	73	10	,	,	,
cord-002209-xs6qigg4	73	11	proliferation	proliferation	NN
cord-002209-xs6qigg4	73	12	rate	rate	NN
cord-002209-xs6qigg4	73	13	,	,	,
cord-002209-xs6qigg4	73	14	and	and	CC
cord-002209-xs6qigg4	73	15	cellular	cellular	JJ
cord-002209-xs6qigg4	73	16	hypertrophy	hypertrophy	NN
cord-002209-xs6qigg4	73	17	with	with	IN
cord-002209-xs6qigg4	73	18	a	a	DT
cord-002209-xs6qigg4	73	19	more	more	RBR
cord-002209-xs6qigg4	73	20	stellate	stellate	JJ
cord-002209-xs6qigg4	73	21	morphology	morphology	NN
cord-002209-xs6qigg4	73	22	.	.	.
cord-002209-xs6qigg4	74	1	The	the	DT
cord-002209-xs6qigg4	74	2	milder	milder	RBR
cord-002209-xs6qigg4	74	3	"	"	``
cord-002209-xs6qigg4	74	4	activated	activate	VBN
cord-002209-xs6qigg4	74	5	"	"	''
cord-002209-xs6qigg4	74	6	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	74	7	can	can	MD
cord-002209-xs6qigg4	74	8	secrete	secrete	VB
cord-002209-xs6qigg4	74	9	a	a	DT
cord-002209-xs6qigg4	74	10	range	range	NN
cord-002209-xs6qigg4	74	11	of	of	IN
cord-002209-xs6qigg4	74	12	factors	factor	NNS
cord-002209-xs6qigg4	74	13	including	include	VBG
cord-002209-xs6qigg4	74	14	;	;	:
cord-002209-xs6qigg4	74	15	neurotrophic	neurotrophic	JJ
cord-002209-xs6qigg4	74	16	factors	factor	NNS
cord-002209-xs6qigg4	74	17	,	,	,
cord-002209-xs6qigg4	74	18	growth	growth	NN
cord-002209-xs6qigg4	74	19	factors	factor	NNS
cord-002209-xs6qigg4	74	20	,	,	,
cord-002209-xs6qigg4	74	21	and	and	CC
cord-002209-xs6qigg4	74	22	cytokines	cytokine	NNS
cord-002209-xs6qigg4	74	23	that	that	WDT
cord-002209-xs6qigg4	74	24	will	will	MD
cord-002209-xs6qigg4	74	25	stimulate	stimulate	VB
cord-002209-xs6qigg4	74	26	re	re	NNS
cord-002209-xs6qigg4	74	27	/	/	NN
cord-002209-xs6qigg4	74	28	myelination	myelination	NN
cord-002209-xs6qigg4	74	29	by	by	IN
cord-002209-xs6qigg4	74	30	promoting	promote	VBG
cord-002209-xs6qigg4	74	31	neuronal	neuronal	JJ
cord-002209-xs6qigg4	74	32	survival	survival	NN
cord-002209-xs6qigg4	74	33	,	,	,
cord-002209-xs6qigg4	74	34	neurite	neurite	NN
cord-002209-xs6qigg4	74	35	outgrowth	outgrowth	NN
cord-002209-xs6qigg4	74	36	,	,	,
cord-002209-xs6qigg4	74	37	neurogenesis	neurogenesis	NN
cord-002209-xs6qigg4	74	38	,	,	,
cord-002209-xs6qigg4	74	39	and/	and/	CD
cord-002209-xs6qigg4	74	40	or	or	CC
cord-002209-xs6qigg4	74	41	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	74	42	precursor	precursor	NN
cord-002209-xs6qigg4	74	43	cell	cell	NN
cord-002209-xs6qigg4	74	44	(	(	-LRB-
cord-002209-xs6qigg4	74	45	OPC	OPC	NNP
cord-002209-xs6qigg4	74	46	)	)	-RRB-
cord-002209-xs6qigg4	74	47	survival	survival	NN
cord-002209-xs6qigg4	74	48	,	,	,
cord-002209-xs6qigg4	74	49	proliferation	proliferation	NN
cord-002209-xs6qigg4	74	50	,	,	,
cord-002209-xs6qigg4	74	51	and/or	and/or	CC
cord-002209-xs6qigg4	74	52	maturation	maturation	NN
cord-002209-xs6qigg4	74	53	.	.	.
cord-002209-xs6qigg4	75	1	Conversely	conversely	RB
cord-002209-xs6qigg4	75	2	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	75	3	that	that	IN
cord-002209-xs6qigg4	75	4	tend	tend	VBP
cord-002209-xs6qigg4	75	5	to	to	TO
cord-002209-xs6qigg4	75	6	have	have	VB
cord-002209-xs6qigg4	75	7	a	a	DT
cord-002209-xs6qigg4	75	8	more	more	RBR
cord-002209-xs6qigg4	75	9	severe	severe	JJ
cord-002209-xs6qigg4	75	10	"	"	``
cord-002209-xs6qigg4	75	11	reactive	reactive	JJ
cord-002209-xs6qigg4	75	12	"	"	''
cord-002209-xs6qigg4	75	13	phenotype	phenotype	NN
cord-002209-xs6qigg4	75	14	,	,	,
cord-002209-xs6qigg4	75	15	possibly	possibly	RB
cord-002209-xs6qigg4	75	16	induced	induce	VBN
cord-002209-xs6qigg4	75	17	by	by	IN
cord-002209-xs6qigg4	75	18	proinflammatory	proinflammatory	JJ
cord-002209-xs6qigg4	75	19	cytokines	cytokine	NNS
cord-002209-xs6qigg4	75	20	/	/	SYM
cord-002209-xs6qigg4	75	21	CNS	cns	NN
cord-002209-xs6qigg4	75	22	tissue	tissue	NN
cord-002209-xs6qigg4	75	23	damage	damage	NN
cord-002209-xs6qigg4	75	24	,	,	,
cord-002209-xs6qigg4	75	25	may	may	MD
cord-002209-xs6qigg4	75	26	secrete	secrete	VB
cord-002209-xs6qigg4	75	27	cytokines	cytokine	NNS
cord-002209-xs6qigg4	75	28	and	and	CC
cord-002209-xs6qigg4	75	29	chemokines	chemokine	NNS
cord-002209-xs6qigg4	75	30	that	that	WDT
cord-002209-xs6qigg4	75	31	lead	lead	VBP
cord-002209-xs6qigg4	75	32	to	to	IN
cord-002209-xs6qigg4	75	33	myelin	myelin	NN
cord-002209-xs6qigg4	75	34	and	and	CC
cord-002209-xs6qigg4	75	35	oligodendrocyte	oligodendrocyte	JJ
cord-002209-xs6qigg4	75	36	damage	damage	NN
cord-002209-xs6qigg4	75	37	in	in	IN
cord-002209-xs6qigg4	75	38	vitro	vitro	FW
cord-002209-xs6qigg4	75	39	,	,	,
cord-002209-xs6qigg4	75	40	suppress	suppress	VB
cord-002209-xs6qigg4	75	41	remyelination	remyelination	NN
cord-002209-xs6qigg4	75	42	,	,	,
cord-002209-xs6qigg4	75	43	delay	delay	NN
cord-002209-xs6qigg4	75	44	disease	disease	NN
cord-002209-xs6qigg4	75	45	recovery	recovery	NN
cord-002209-xs6qigg4	75	46	in	in	IN
cord-002209-xs6qigg4	75	47	experimental	experimental	JJ
cord-002209-xs6qigg4	75	48	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	75	49	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	75	50	(	(	-LRB-
cord-002209-xs6qigg4	75	51	EAE	EAE	NNP
cord-002209-xs6qigg4	75	52	)	)	-RRB-
cord-002209-xs6qigg4	75	53	,	,	,
cord-002209-xs6qigg4	75	54	and	and	CC
cord-002209-xs6qigg4	75	55	suppress	suppress	VB
cord-002209-xs6qigg4	75	56	myelination	myelination	NN
cord-002209-xs6qigg4	75	57	in	in	IN
cord-002209-xs6qigg4	75	58	myelinating	myelinate	VBG
cord-002209-xs6qigg4	75	59	embryonic	embryonic	JJ
cord-002209-xs6qigg4	75	60	rat	rat	NN
cord-002209-xs6qigg4	75	61	mixed	mix	VBN
cord-002209-xs6qigg4	75	62	spinal	spinal	JJ
cord-002209-xs6qigg4	75	63	cord	cord	NN
cord-002209-xs6qigg4	75	64	cultures	culture	NNS
cord-002209-xs6qigg4	75	65	.	.	.
cord-002209-xs6qigg4	76	1	However	however	RB
cord-002209-xs6qigg4	76	2	,	,	,
cord-002209-xs6qigg4	76	3	these	these	DT
cord-002209-xs6qigg4	76	4	reactive	reactive	JJ
cord-002209-xs6qigg4	76	5	scar	scar	NN
cord-002209-xs6qigg4	76	6	forming	form	VBG
cord-002209-xs6qigg4	76	7	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	76	8	can	can	MD
cord-002209-xs6qigg4	76	9	also	also	RB
cord-002209-xs6qigg4	76	10	protect	protect	VB
cord-002209-xs6qigg4	76	11	CNS	cns	JJ
cord-002209-xs6qigg4	76	12	tissue	tissue	NN
cord-002209-xs6qigg4	76	13	by	by	IN
cord-002209-xs6qigg4	76	14	preventing	prevent	VBG
cord-002209-xs6qigg4	76	15	immune	immune	JJ
cord-002209-xs6qigg4	76	16	cells	cell	NNS
cord-002209-xs6qigg4	76	17	from	from	IN
cord-002209-xs6qigg4	76	18	invading	invade	VBG
cord-002209-xs6qigg4	76	19	and	and	CC
cord-002209-xs6qigg4	76	20	exerting	exert	VBG
cord-002209-xs6qigg4	76	21	a	a	DT
cord-002209-xs6qigg4	76	22	pro	pro	JJ
cord-002209-xs6qigg4	76	23	-	-	JJ
cord-002209-xs6qigg4	76	24	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	76	25	response	response	NN
cord-002209-xs6qigg4	76	26	and	and	CC
cord-002209-xs6qigg4	76	27	have	have	VBP
cord-002209-xs6qigg4	76	28	been	be	VBN
cord-002209-xs6qigg4	76	29	shown	show	VBN
cord-002209-xs6qigg4	76	30	to	to	TO
cord-002209-xs6qigg4	76	31	even	even	RB
cord-002209-xs6qigg4	76	32	ameliorate	ameliorate	VB
cord-002209-xs6qigg4	76	33	EAE	EAE	NNP
cord-002209-xs6qigg4	76	34	.	.	.
cord-002209-xs6qigg4	77	1	growth	growth	NN
cord-002209-xs6qigg4	77	2	factor	factor	NN
cord-002209-xs6qigg4	77	3	(	(	-LRB-
cord-002209-xs6qigg4	77	4	NGF	NGF	NNP
cord-002209-xs6qigg4	77	5	)	)	-RRB-
cord-002209-xs6qigg4	77	6	,	,	,
cord-002209-xs6qigg4	77	7	brain	brain	NN
cord-002209-xs6qigg4	77	8	-	-	HYPH
cord-002209-xs6qigg4	77	9	derived	derive	VBN
cord-002209-xs6qigg4	77	10	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	77	11	factor	factor	NN
cord-002209-xs6qigg4	77	12	(	(	-LRB-
cord-002209-xs6qigg4	77	13	BDNF	BDNF	NNP
cord-002209-xs6qigg4	77	14	)	)	-RRB-
cord-002209-xs6qigg4	77	15	,	,	,
cord-002209-xs6qigg4	77	16	activity	activity	NN
cord-002209-xs6qigg4	77	17	dependent	dependent	JJ
cord-002209-xs6qigg4	77	18	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	77	19	factor	factor	NN
cord-002209-xs6qigg4	77	20	(	(	-LRB-
cord-002209-xs6qigg4	77	21	ADNF	ADNF	NNP
cord-002209-xs6qigg4	77	22	)	)	-RRB-
cord-002209-xs6qigg4	77	23	,	,	,
cord-002209-xs6qigg4	77	24	hepatocyte	hepatocyte	NN
cord-002209-xs6qigg4	77	25	growth	growth	NN
cord-002209-xs6qigg4	77	26	factor	factor	NN
cord-002209-xs6qigg4	77	27	(	(	-LRB-
cord-002209-xs6qigg4	77	28	HGF	HGF	NNP
cord-002209-xs6qigg4	77	29	)	)	-RRB-
cord-002209-xs6qigg4	77	30	,	,	,
cord-002209-xs6qigg4	77	31	leukaemia	leukaemia	NN
cord-002209-xs6qigg4	77	32	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	77	33	factor	factor	NN
cord-002209-xs6qigg4	77	34	(	(	-LRB-
cord-002209-xs6qigg4	77	35	LIF	LIF	NNP
cord-002209-xs6qigg4	77	36	)	)	-RRB-
cord-002209-xs6qigg4	77	37	,	,	,
cord-002209-xs6qigg4	77	38	fibroblast	fibroblast	NN
cord-002209-xs6qigg4	77	39	growth	growth	NN
cord-002209-xs6qigg4	77	40	factor-2	factor-2	NNP
cord-002209-xs6qigg4	77	41	(	(	-LRB-
cord-002209-xs6qigg4	77	42	FGF-2	FGF-2	NNP
cord-002209-xs6qigg4	77	43	)	)	-RRB-
cord-002209-xs6qigg4	77	44	and	and	CC
cord-002209-xs6qigg4	77	45	CNTF	CNTF	NNP
cord-002209-xs6qigg4	77	46	(	(	-LRB-
cord-002209-xs6qigg4	77	47	Schwartz	Schwartz	NNP
cord-002209-xs6qigg4	77	48	and	and	CC
cord-002209-xs6qigg4	77	49	Nishiyama	Nishiyama	NNP
cord-002209-xs6qigg4	77	50	,	,	,
cord-002209-xs6qigg4	77	51	1994	1994	CD
cord-002209-xs6qigg4	77	52	;	;	.
cord-002209-xs6qigg4	78	1	Rudge	Rudge	NNP
cord-002209-xs6qigg4	78	2	et	et	NNP
cord-002209-xs6qigg4	78	3	al	al	NNP
cord-002209-xs6qigg4	78	4	.	.	NNP
cord-002209-xs6qigg4	78	5	,	,	,
cord-002209-xs6qigg4	78	6	1995	1995	CD
cord-002209-xs6qigg4	78	7	;	;	:
cord-002209-xs6qigg4	78	8	Uchida	Uchida	NNP
cord-002209-xs6qigg4	78	9	et	et	NNP
cord-002209-xs6qigg4	78	10	al	al	NNP
cord-002209-xs6qigg4	78	11	.	.	NNP
cord-002209-xs6qigg4	78	12	,	,	,
cord-002209-xs6qigg4	78	13	1998	1998	CD
cord-002209-xs6qigg4	78	14	;	;	:
cord-002209-xs6qigg4	78	15	Dreyfus	Dreyfus	NNP
cord-002209-xs6qigg4	78	16	et	et	NNP
cord-002209-xs6qigg4	78	17	al	al	NNP
cord-002209-xs6qigg4	78	18	.	.	NNP
cord-002209-xs6qigg4	78	19	,	,	,
cord-002209-xs6qigg4	78	20	1999	1999	CD
cord-002209-xs6qigg4	78	21	;	;	:
cord-002209-xs6qigg4	78	22	Messersmith	Messersmith	NNP
cord-002209-xs6qigg4	78	23	et	et	NNP
cord-002209-xs6qigg4	78	24	al	al	NNP
cord-002209-xs6qigg4	78	25	.	.	NNP
cord-002209-xs6qigg4	78	26	,	,	,
cord-002209-xs6qigg4	78	27	2000	2000	CD
cord-002209-xs6qigg4	79	1	;	;	:
cord-002209-xs6qigg4	79	2	Albrecht	Albrecht	NNP
cord-002209-xs6qigg4	79	3	et	et	NNP
cord-002209-xs6qigg4	79	4	al	al	NNP
cord-002209-xs6qigg4	79	5	.	.	NNP
cord-002209-xs6qigg4	79	6	,	,	,
cord-002209-xs6qigg4	79	7	2002	2002	CD
cord-002209-xs6qigg4	79	8	;	;	:
cord-002209-xs6qigg4	80	1	Fig	Fig	NNP
cord-002209-xs6qigg4	80	2	.	.	NNP
cord-002209-xs6qigg4	80	3	3	3	CD
cord-002209-xs6qigg4	80	4	)	)	-RRB-
cord-002209-xs6qigg4	80	5	.	.	.
cord-002209-xs6qigg4	81	1	Moreover	moreover	RB
cord-002209-xs6qigg4	81	2	,	,	,
cord-002209-xs6qigg4	81	3	cultured	cultured	JJ
cord-002209-xs6qigg4	81	4	spinal	spinal	JJ
cord-002209-xs6qigg4	81	5	cord	cord	NN
cord-002209-xs6qigg4	81	6	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	81	7	,	,	,
cord-002209-xs6qigg4	81	8	treated	treat	VBN
cord-002209-xs6qigg4	81	9	with	with	IN
cord-002209-xs6qigg4	81	10	CNTF	CNTF	NNP
cord-002209-xs6qigg4	81	11	,	,	,
cord-002209-xs6qigg4	81	12	support	support	VB
cord-002209-xs6qigg4	81	13	the	the	DT
cord-002209-xs6qigg4	81	14	survival	survival	NN
cord-002209-xs6qigg4	81	15	of	of	IN
cord-002209-xs6qigg4	81	16	a	a	DT
cord-002209-xs6qigg4	81	17	significantly	significantly	RB
cord-002209-xs6qigg4	81	18	greater	great	JJR
cord-002209-xs6qigg4	81	19	number	number	NN
cord-002209-xs6qigg4	81	20	of	of	IN
cord-002209-xs6qigg4	81	21	ventral	ventral	JJ
cord-002209-xs6qigg4	81	22	spinal	spinal	JJ
cord-002209-xs6qigg4	81	23	motor	motor	NN
cord-002209-xs6qigg4	81	24	neurons	neuron	NNS
cord-002209-xs6qigg4	81	25	and	and	CC
cord-002209-xs6qigg4	81	26	promote	promote	VB
cord-002209-xs6qigg4	81	27	neurite	neurite	NN
cord-002209-xs6qigg4	81	28	outgrowth	outgrowth	NN
cord-002209-xs6qigg4	81	29	better	well	RBR
cord-002209-xs6qigg4	81	30	than	than	IN
cord-002209-xs6qigg4	81	31	unstimulated	unstimulated	JJ
cord-002209-xs6qigg4	81	32	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	81	33	(	(	-LRB-
cord-002209-xs6qigg4	82	1	Albrecht	Albrecht	NNP
cord-002209-xs6qigg4	82	2	et	et	NNP
cord-002209-xs6qigg4	82	3	al	al	NNP
cord-002209-xs6qigg4	82	4	.	.	NNP
cord-002209-xs6qigg4	82	5	,	,	,
cord-002209-xs6qigg4	82	6	2002	2002	CD
cord-002209-xs6qigg4	82	7	)	)	-RRB-
cord-002209-xs6qigg4	82	8	.	.	.
cord-002209-xs6qigg4	83	1	Other	other	JJ
cord-002209-xs6qigg4	83	2	researchers	researcher	NNS
cord-002209-xs6qigg4	83	3	have	have	VBP
cord-002209-xs6qigg4	83	4	shown	show	VBN
cord-002209-xs6qigg4	83	5	that	that	IN
cord-002209-xs6qigg4	83	6	cytokine	cytokine	NN
cord-002209-xs6qigg4	83	7	-	-	HYPH
cord-002209-xs6qigg4	83	8	activated	activate	VBN
cord-002209-xs6qigg4	83	9	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	83	10	can	can	MD
cord-002209-xs6qigg4	83	11	promote	promote	VB
cord-002209-xs6qigg4	83	12	neurogenesis	neurogenesis	NN
cord-002209-xs6qigg4	83	13	,	,	,
cord-002209-xs6qigg4	83	14	possibly	possibly	RB
cord-002209-xs6qigg4	83	15	by	by	IN
cord-002209-xs6qigg4	83	16	stimulating	stimulate	VBG
cord-002209-xs6qigg4	83	17	the	the	DT
cord-002209-xs6qigg4	83	18	differentiation	differentiation	NN
cord-002209-xs6qigg4	83	19	of	of	IN
cord-002209-xs6qigg4	83	20	neural	neural	JJ
cord-002209-xs6qigg4	83	21	stem	stem	NN
cord-002209-xs6qigg4	83	22	cells	cell	NNS
cord-002209-xs6qigg4	83	23	(	(	-LRB-
cord-002209-xs6qigg4	83	24	NSCs	nscs	NN
cord-002209-xs6qigg4	83	25	)	)	-RRB-
cord-002209-xs6qigg4	83	26	residing	reside	VBG
cord-002209-xs6qigg4	83	27	in	in	IN
cord-002209-xs6qigg4	83	28	the	the	DT
cord-002209-xs6qigg4	83	29	subventricular	subventricular	NNP
cord-002209-xs6qigg4	83	30	zone	zone	NNP
cord-002209-xs6qigg4	83	31	and	and	CC
cord-002209-xs6qigg4	83	32	the	the	DT
cord-002209-xs6qigg4	83	33	dentate	dentate	NN
cord-002209-xs6qigg4	83	34	gyrus	gyrus	NN
cord-002209-xs6qigg4	83	35	in	in	IN
cord-002209-xs6qigg4	83	36	adult	adult	NN
cord-002209-xs6qigg4	83	37	animals	animal	NNS
cord-002209-xs6qigg4	83	38	(	(	-LRB-
cord-002209-xs6qigg4	83	39	Liberto	Liberto	NNP
cord-002209-xs6qigg4	83	40	et	et	NNP
cord-002209-xs6qigg4	83	41	al	al	NNP
cord-002209-xs6qigg4	83	42	.	.	NNP
cord-002209-xs6qigg4	83	43	,	,	,
cord-002209-xs6qigg4	83	44	2004	2004	CD
cord-002209-xs6qigg4	83	45	)	)	-RRB-
cord-002209-xs6qigg4	83	46	.	.	.
cord-002209-xs6qigg4	84	1	Because	because	IN
cord-002209-xs6qigg4	84	2	these	these	DT
cord-002209-xs6qigg4	84	3	multipotent	multipotent	JJ
cord-002209-xs6qigg4	84	4	NSCs	nscs	NN
cord-002209-xs6qigg4	84	5	can	can	MD
cord-002209-xs6qigg4	84	6	migrate	migrate	VB
cord-002209-xs6qigg4	84	7	beyond	beyond	IN
cord-002209-xs6qigg4	84	8	their	-PRON-	PRP$
cord-002209-xs6qigg4	84	9	sites	site	NNS
cord-002209-xs6qigg4	84	10	of	of	IN
cord-002209-xs6qigg4	84	11	origin	origin	NN
cord-002209-xs6qigg4	84	12	and	and	CC
cord-002209-xs6qigg4	84	13	can	can	MD
cord-002209-xs6qigg4	84	14	later	later	RB
cord-002209-xs6qigg4	84	15	differentiate	differentiate	VB
cord-002209-xs6qigg4	84	16	into	into	IN
cord-002209-xs6qigg4	84	17	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	84	18	,	,	,
cord-002209-xs6qigg4	84	19	neurons	neuron	NNS
cord-002209-xs6qigg4	84	20	and	and	CC
cord-002209-xs6qigg4	84	21	microglia	microglia	NNS
cord-002209-xs6qigg4	84	22	,	,	,
cord-002209-xs6qigg4	84	23	they	-PRON-	PRP
cord-002209-xs6qigg4	84	24	have	have	VBP
cord-002209-xs6qigg4	84	25	the	the	DT
cord-002209-xs6qigg4	84	26	potential	potential	NN
cord-002209-xs6qigg4	84	27	to	to	TO
cord-002209-xs6qigg4	84	28	enhance	enhance	VB
cord-002209-xs6qigg4	84	29	recovery	recovery	NN
cord-002209-xs6qigg4	84	30	from	from	IN
cord-002209-xs6qigg4	84	31	CNS	CNS	NNP
cord-002209-xs6qigg4	84	32	injury	injury	NN
cord-002209-xs6qigg4	84	33	and	and	CC
cord-002209-xs6qigg4	84	34	disease	disease	NN
cord-002209-xs6qigg4	84	35	.	.	.
cord-002209-xs6qigg4	85	1	Importantly	importantly	RB
cord-002209-xs6qigg4	85	2	,	,	,
cord-002209-xs6qigg4	85	3	activated	activate	VBN
cord-002209-xs6qigg4	85	4	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	85	5	have	have	VBP
cord-002209-xs6qigg4	85	6	also	also	RB
cord-002209-xs6qigg4	85	7	shown	show	VBN
cord-002209-xs6qigg4	85	8	positive	positive	JJ
cord-002209-xs6qigg4	85	9	effects	effect	NNS
cord-002209-xs6qigg4	85	10	on	on	IN
cord-002209-xs6qigg4	85	11	myelination	myelination	NN
cord-002209-xs6qigg4	85	12	.	.	.
cord-002209-xs6qigg4	86	1	Our	-PRON-	PRP$
cord-002209-xs6qigg4	86	2	own	own	JJ
cord-002209-xs6qigg4	86	3	investigations	investigation	NNS
cord-002209-xs6qigg4	86	4	have	have	VBP
cord-002209-xs6qigg4	86	5	shown	show	VBN
cord-002209-xs6qigg4	86	6	that	that	IN
cord-002209-xs6qigg4	86	7	CNTF	CNTF	NNP
cord-002209-xs6qigg4	86	8	activated	activate	VBN
cord-002209-xs6qigg4	86	9	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	86	10	can	can	MD
cord-002209-xs6qigg4	86	11	promote	promote	VB
cord-002209-xs6qigg4	86	12	the	the	DT
cord-002209-xs6qigg4	86	13	percentage	percentage	NN
cord-002209-xs6qigg4	86	14	of	of	IN
cord-002209-xs6qigg4	86	15	myelinated	myelinated	JJ
cord-002209-xs6qigg4	86	16	fibres	fibre	NNS
cord-002209-xs6qigg4	86	17	in	in	IN
cord-002209-xs6qigg4	86	18	CNS	CNS	NNP
cord-002209-xs6qigg4	86	19	rat	rat	NN
cord-002209-xs6qigg4	86	20	cultures	culture	NNS
cord-002209-xs6qigg4	87	1	(	(	-LRB-
cord-002209-xs6qigg4	87	2	Nash	Nash	NNP
cord-002209-xs6qigg4	87	3	et	et	NNP
cord-002209-xs6qigg4	87	4	al	al	NNP
cord-002209-xs6qigg4	87	5	.	.	NNP
cord-002209-xs6qigg4	87	6	,	,	,
cord-002209-xs6qigg4	87	7	2011b	2011b	CD
cord-002209-xs6qigg4	87	8	)	)	-RRB-
cord-002209-xs6qigg4	87	9	.	.	.
cord-002209-xs6qigg4	88	1	Further	further	JJ
cord-002209-xs6qigg4	88	2	evidence	evidence	NN
cord-002209-xs6qigg4	88	3	of	of	IN
cord-002209-xs6qigg4	88	4	this	this	DT
cord-002209-xs6qigg4	88	5	has	have	VBZ
cord-002209-xs6qigg4	88	6	been	be	VBN
cord-002209-xs6qigg4	88	7	shown	show	VBN
cord-002209-xs6qigg4	88	8	in	in	IN
cord-002209-xs6qigg4	88	9	mice	mouse	NNS
cord-002209-xs6qigg4	88	10	infected	infect	VBN
cord-002209-xs6qigg4	88	11	with	with	IN
cord-002209-xs6qigg4	88	12	the	the	DT
cord-002209-xs6qigg4	88	13	A-59	A-59	NNP
cord-002209-xs6qigg4	88	14	strain	strain	NN
cord-002209-xs6qigg4	88	15	of	of	IN
cord-002209-xs6qigg4	88	16	the	the	DT
cord-002209-xs6qigg4	88	17	mouse	mouse	NN
cord-002209-xs6qigg4	88	18	hepatitis	hepatitis	NN
cord-002209-xs6qigg4	88	19	virus	virus	NN
cord-002209-xs6qigg4	88	20	(	(	-LRB-
cord-002209-xs6qigg4	88	21	MHV	MHV	NNP
cord-002209-xs6qigg4	88	22	-	-	HYPH
cord-002209-xs6qigg4	88	23	A59	A59	NNP
cord-002209-xs6qigg4	88	24	)	)	-RRB-
cord-002209-xs6qigg4	88	25	,	,	,
cord-002209-xs6qigg4	88	26	an	an	DT
cord-002209-xs6qigg4	88	27	animal	animal	NN
cord-002209-xs6qigg4	88	28	model	model	NN
cord-002209-xs6qigg4	88	29	for	for	IN
cord-002209-xs6qigg4	88	30	MS	MS	NNP
cord-002209-xs6qigg4	88	31	(	(	-LRB-
cord-002209-xs6qigg4	88	32	Jordan	Jordan	NNP
cord-002209-xs6qigg4	88	33	et	et	NNP
cord-002209-xs6qigg4	88	34	al	al	NNP
cord-002209-xs6qigg4	88	35	.	.	NNP
cord-002209-xs6qigg4	88	36	,	,	,
cord-002209-xs6qigg4	88	37	1989	1989	CD
cord-002209-xs6qigg4	88	38	,	,	,
cord-002209-xs6qigg4	88	39	Messersmith	Messersmith	NNP
cord-002209-xs6qigg4	88	40	et	et	NNP
cord-002209-xs6qigg4	88	41	al	al	NNP
cord-002209-xs6qigg4	88	42	.	.	NNP
cord-002209-xs6qigg4	88	43	,	,	,
cord-002209-xs6qigg4	88	44	2000	2000	CD
cord-002209-xs6qigg4	88	45	.	.	.
cord-002209-xs6qigg4	89	1	These	these	DT
cord-002209-xs6qigg4	89	2	animals	animal	NNS
cord-002209-xs6qigg4	89	3	have	have	VBP
cord-002209-xs6qigg4	89	4	been	be	VBN
cord-002209-xs6qigg4	89	5	shown	show	VBN
cord-002209-xs6qigg4	89	6	to	to	IN
cord-002209-xs6qigg4	89	7	secrete	secrete	VB
cord-002209-xs6qigg4	89	8	increased	increase	VBN
cord-002209-xs6qigg4	89	9	levels	level	NNS
cord-002209-xs6qigg4	89	10	of	of	IN
cord-002209-xs6qigg4	89	11	CNTF	CNTF	NNP
cord-002209-xs6qigg4	89	12	during	during	IN
cord-002209-xs6qigg4	89	13	the	the	DT
cord-002209-xs6qigg4	89	14	remyelination	remyelination	NN
cord-002209-xs6qigg4	89	15	phase	phase	NN
cord-002209-xs6qigg4	89	16	and	and	CC
cord-002209-xs6qigg4	89	17	CNTF	CNTF	NNP
cord-002209-xs6qigg4	89	18	mRNA	mRNA	NNP
cord-002209-xs6qigg4	89	19	is	be	VBZ
cord-002209-xs6qigg4	89	20	induced	induce	VBN
cord-002209-xs6qigg4	89	21	in	in	IN
cord-002209-xs6qigg4	89	22	the	the	DT
cord-002209-xs6qigg4	89	23	remyelinating	remyelinate	VBG
cord-002209-xs6qigg4	89	24	regions	region	NNS
cord-002209-xs6qigg4	89	25	in	in	IN
cord-002209-xs6qigg4	89	26	cells	cell	NNS
cord-002209-xs6qigg4	89	27	exhibiting	exhibit	VBG
cord-002209-xs6qigg4	89	28	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	89	29	features	feature	NNS
cord-002209-xs6qigg4	89	30	(	(	-LRB-
cord-002209-xs6qigg4	90	1	Albrecht	Albrecht	NNP
cord-002209-xs6qigg4	90	2	et	et	NNP
cord-002209-xs6qigg4	90	3	al	al	NNP
cord-002209-xs6qigg4	90	4	.	.	NNP
cord-002209-xs6qigg4	90	5	,	,	,
cord-002209-xs6qigg4	90	6	2003	2003	CD
cord-002209-xs6qigg4	90	7	)	)	-RRB-
cord-002209-xs6qigg4	90	8	.	.	.
cord-002209-xs6qigg4	91	1	It	-PRON-	PRP
cord-002209-xs6qigg4	91	2	is	be	VBZ
cord-002209-xs6qigg4	91	3	suggested	suggest	VBN
cord-002209-xs6qigg4	91	4	that	that	IN
cord-002209-xs6qigg4	91	5	the	the	DT
cord-002209-xs6qigg4	91	6	increase	increase	NN
cord-002209-xs6qigg4	91	7	in	in	IN
cord-002209-xs6qigg4	91	8	IL-1β	il-1β	DT
cord-002209-xs6qigg4	91	9	levels	level	NNS
cord-002209-xs6qigg4	91	10	at	at	IN
cord-002209-xs6qigg4	91	11	early	early	JJ
cord-002209-xs6qigg4	91	12	stages	stage	NNS
cord-002209-xs6qigg4	91	13	of	of	IN
cord-002209-xs6qigg4	91	14	CNS	CNS	NNP
cord-002209-xs6qigg4	91	15	pathology	pathology	NN
cord-002209-xs6qigg4	91	16	stimulates	stimulate	VBZ
cord-002209-xs6qigg4	91	17	the	the	DT
cord-002209-xs6qigg4	91	18	induction	induction	NN
cord-002209-xs6qigg4	91	19	of	of	IN
cord-002209-xs6qigg4	91	20	CNTF	CNTF	NNP
cord-002209-xs6qigg4	91	21	mRNA	mRNA	NNP
cord-002209-xs6qigg4	91	22	and	and	CC
cord-002209-xs6qigg4	91	23	protein	protein	NN
cord-002209-xs6qigg4	91	24	in	in	IN
cord-002209-xs6qigg4	91	25	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	92	1	(	(	-LRB-
cord-002209-xs6qigg4	92	2	Stöckli	Stöckli	NNP
cord-002209-xs6qigg4	92	3	et	et	FW
cord-002209-xs6qigg4	92	4	al	al	NNP
cord-002209-xs6qigg4	92	5	.	.	NNP
cord-002209-xs6qigg4	92	6	,	,	,
cord-002209-xs6qigg4	92	7	1991	1991	CD
cord-002209-xs6qigg4	92	8	;	;	:
cord-002209-xs6qigg4	92	9	Guthrie	Guthrie	NNP
cord-002209-xs6qigg4	92	10	et	et	NNP
cord-002209-xs6qigg4	92	11	al	al	NNP
cord-002209-xs6qigg4	92	12	.	.	NNP
cord-002209-xs6qigg4	92	13	,	,	,
cord-002209-xs6qigg4	92	14	1997	1997	CD
cord-002209-xs6qigg4	92	15	;	;	:
cord-002209-xs6qigg4	92	16	Dallner	Dallner	NNP
cord-002209-xs6qigg4	92	17	et	et	NNP
cord-002209-xs6qigg4	92	18	al	al	NNP
cord-002209-xs6qigg4	92	19	.	.	NNP
cord-002209-xs6qigg4	92	20	,	,	,
cord-002209-xs6qigg4	92	21	2002	2002	CD
cord-002209-xs6qigg4	93	1	;	;	:
cord-002209-xs6qigg4	93	2	Liberto	Liberto	NNP
cord-002209-xs6qigg4	93	3	et	et	NNP
cord-002209-xs6qigg4	93	4	al	al	NNP
cord-002209-xs6qigg4	93	5	.	.	NNP
cord-002209-xs6qigg4	93	6	,	,	,
cord-002209-xs6qigg4	93	7	2004	2004	CD
cord-002209-xs6qigg4	93	8	)	)	-RRB-
cord-002209-xs6qigg4	93	9	,	,	,
cord-002209-xs6qigg4	93	10	a	a	DT
cord-002209-xs6qigg4	93	11	phenomenon	phenomenon	NN
cord-002209-xs6qigg4	93	12	which	which	WDT
cord-002209-xs6qigg4	93	13	appears	appear	VBZ
cord-002209-xs6qigg4	93	14	to	to	TO
cord-002209-xs6qigg4	93	15	be	be	VB
cord-002209-xs6qigg4	93	16	important	important	JJ
cord-002209-xs6qigg4	93	17	for	for	IN
cord-002209-xs6qigg4	93	18	remyelination	remyelination	NN
cord-002209-xs6qigg4	93	19	(	(	-LRB-
cord-002209-xs6qigg4	93	20	Herx	Herx	NNP
cord-002209-xs6qigg4	93	21	et	et	NNP
cord-002209-xs6qigg4	93	22	al	al	NNP
cord-002209-xs6qigg4	93	23	.	.	NNP
cord-002209-xs6qigg4	93	24	,	,	,
cord-002209-xs6qigg4	93	25	2000	2000	CD
cord-002209-xs6qigg4	93	26	)	)	-RRB-
cord-002209-xs6qigg4	93	27	.	.	.
cord-002209-xs6qigg4	94	1	This	this	DT
cord-002209-xs6qigg4	94	2	could	could	MD
cord-002209-xs6qigg4	94	3	be	be	VB
cord-002209-xs6qigg4	94	4	due	due	JJ
cord-002209-xs6qigg4	94	5	to	to	IN
cord-002209-xs6qigg4	95	1	FGF-2	FGF-2	NNP
cord-002209-xs6qigg4	95	2	signalling	signal	VBG
cord-002209-xs6qigg4	95	3	as	as	IN
cord-002209-xs6qigg4	95	4	CNTF	CNTF	NNP
cord-002209-xs6qigg4	95	5	treatment	treatment	NN
cord-002209-xs6qigg4	95	6	elevates	elevate	VBZ
cord-002209-xs6qigg4	95	7	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	95	8	levels	level	NNS
cord-002209-xs6qigg4	95	9	of	of	IN
cord-002209-xs6qigg4	95	10	Fgf-2	Fgf-2	NNP
cord-002209-xs6qigg4	95	11	mRNA	mRNA	NNP
cord-002209-xs6qigg4	95	12	significantly	significantly	RB
cord-002209-xs6qigg4	95	13	,	,	,
cord-002209-xs6qigg4	95	14	whereas	whereas	RB
cord-002209-xs6qigg4	95	15	,	,	,
cord-002209-xs6qigg4	95	16	IL-1	IL-1	NNP
cord-002209-xs6qigg4	95	17	β	β	NNP
cord-002209-xs6qigg4	95	18	shows	show	VBZ
cord-002209-xs6qigg4	95	19	no	no	DT
cord-002209-xs6qigg4	95	20	effect	effect	NN
cord-002209-xs6qigg4	95	21	(	(	-LRB-
cord-002209-xs6qigg4	96	1	Albrecht	Albrecht	NNP
cord-002209-xs6qigg4	96	2	et	et	NNP
cord-002209-xs6qigg4	96	3	al	al	NNP
cord-002209-xs6qigg4	96	4	.	.	NNP
cord-002209-xs6qigg4	96	5	,	,	,
cord-002209-xs6qigg4	96	6	2003	2003	CD
cord-002209-xs6qigg4	96	7	)	)	-RRB-
cord-002209-xs6qigg4	96	8	.	.	.
cord-002209-xs6qigg4	97	1	Since	since	IN
cord-002209-xs6qigg4	97	2	FGF-2	FGF-2	NNP
cord-002209-xs6qigg4	97	3	can	can	MD
cord-002209-xs6qigg4	97	4	enhance	enhance	VB
cord-002209-xs6qigg4	97	5	OPC	opc	NN
cord-002209-xs6qigg4	97	6	proliferation	proliferation	NN
cord-002209-xs6qigg4	97	7	(	(	-LRB-
cord-002209-xs6qigg4	97	8	Albrecht	Albrecht	NNP
cord-002209-xs6qigg4	97	9	et	et	NNP
cord-002209-xs6qigg4	97	10	al	al	NNP
cord-002209-xs6qigg4	97	11	.	.	NNP
cord-002209-xs6qigg4	97	12	,	,	,
cord-002209-xs6qigg4	97	13	2003	2003	CD
cord-002209-xs6qigg4	97	14	)	)	-RRB-
cord-002209-xs6qigg4	97	15	,	,	,
cord-002209-xs6qigg4	97	16	it	-PRON-	PRP
cord-002209-xs6qigg4	97	17	may	may	MD
cord-002209-xs6qigg4	97	18	produce	produce	VB
cord-002209-xs6qigg4	97	19	more	more	JJR
cord-002209-xs6qigg4	97	20	OPCs	opc	NNS
cord-002209-xs6qigg4	97	21	for	for	IN
cord-002209-xs6qigg4	97	22	subsequent	subsequent	JJ
cord-002209-xs6qigg4	97	23	myelination	myelination	NN
cord-002209-xs6qigg4	97	24	(	(	-LRB-
cord-002209-xs6qigg4	97	25	Redwine	Redwine	NNP
cord-002209-xs6qigg4	97	26	et	et	NNP
cord-002209-xs6qigg4	97	27	al	al	NNP
cord-002209-xs6qigg4	97	28	.	.	NNP
cord-002209-xs6qigg4	97	29	,	,	,
cord-002209-xs6qigg4	97	30	1997	1997	CD
cord-002209-xs6qigg4	97	31	;	;	:
cord-002209-xs6qigg4	97	32	Messersmith	Messersmith	NNP
cord-002209-xs6qigg4	97	33	et	et	FW
cord-002209-xs6qigg4	97	34	al	al	NNP
cord-002209-xs6qigg4	97	35	.	.	NNP
cord-002209-xs6qigg4	97	36	,	,	,
cord-002209-xs6qigg4	97	37	2000	2000	CD
cord-002209-xs6qigg4	97	38	)	)	-RRB-
cord-002209-xs6qigg4	97	39	.	.	.
cord-002209-xs6qigg4	98	1	Moreover	moreover	RB
cord-002209-xs6qigg4	98	2	,	,	,
cord-002209-xs6qigg4	98	3	if	if	IN
cord-002209-xs6qigg4	98	4	the	the	DT
cord-002209-xs6qigg4	98	5	gp130	gp130	NNP
cord-002209-xs6qigg4	98	6	receptor	receptor	NN
cord-002209-xs6qigg4	98	7	,	,	,
cord-002209-xs6qigg4	98	8	the	the	DT
cord-002209-xs6qigg4	98	9	ubiquitous	ubiquitous	JJ
cord-002209-xs6qigg4	98	10	signal	signal	NN
cord-002209-xs6qigg4	98	11	transducer	transducer	NN
cord-002209-xs6qigg4	98	12	for	for	IN
cord-002209-xs6qigg4	98	13	CNTF	CNTF	NNP
cord-002209-xs6qigg4	98	14	and	and	CC
cord-002209-xs6qigg4	98	15	all	all	DT
cord-002209-xs6qigg4	98	16	IL-6	IL-6	NNP
cord-002209-xs6qigg4	98	17	family	family	NN
cord-002209-xs6qigg4	98	18	members	member	NNS
cord-002209-xs6qigg4	98	19	,	,	,
cord-002209-xs6qigg4	98	20	is	be	VBZ
cord-002209-xs6qigg4	98	21	genetically	genetically	RB
cord-002209-xs6qigg4	98	22	removed	remove	VBN
cord-002209-xs6qigg4	98	23	from	from	IN
cord-002209-xs6qigg4	98	24	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	98	25	,	,	,
cord-002209-xs6qigg4	98	26	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	98	27	survival	survival	NN
cord-002209-xs6qigg4	98	28	was	be	VBD
cord-002209-xs6qigg4	98	29	poor	poor	JJ
cord-002209-xs6qigg4	98	30	,	,	,
cord-002209-xs6qigg4	98	31	there	there	EX
cord-002209-xs6qigg4	98	32	was	be	VBD
cord-002209-xs6qigg4	98	33	a	a	DT
cord-002209-xs6qigg4	98	34	reduction	reduction	NN
cord-002209-xs6qigg4	98	35	in	in	IN
cord-002209-xs6qigg4	98	36	the	the	DT
cord-002209-xs6qigg4	98	37	development	development	NN
cord-002209-xs6qigg4	98	38	of	of	IN
cord-002209-xs6qigg4	98	39	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	98	40	,	,	,
cord-002209-xs6qigg4	98	41	and	and	CC
cord-002209-xs6qigg4	98	42	larger	large	JJR
cord-002209-xs6qigg4	98	43	areas	area	NNS
cord-002209-xs6qigg4	98	44	of	of	IN
cord-002209-xs6qigg4	98	45	demyelination	demyelination	NN
cord-002209-xs6qigg4	98	46	formed	form	VBN
cord-002209-xs6qigg4	98	47	with	with	IN
cord-002209-xs6qigg4	98	48	a	a	DT
cord-002209-xs6qigg4	98	49	greater	great	JJR
cord-002209-xs6qigg4	98	50	proinflammatory	proinflammatory	JJ
cord-002209-xs6qigg4	98	51	T	t	NN
cord-002209-xs6qigg4	98	52	cell	cell	NN
cord-002209-xs6qigg4	98	53	response	response	NN
cord-002209-xs6qigg4	98	54	(	(	-LRB-
cord-002209-xs6qigg4	98	55	Haroon	Haroon	NNP
cord-002209-xs6qigg4	98	56	et	et	NNP
cord-002209-xs6qigg4	98	57	al	al	NNP
cord-002209-xs6qigg4	98	58	.	.	NNP
cord-002209-xs6qigg4	98	59	,	,	,
cord-002209-xs6qigg4	98	60	2011	2011	CD
cord-002209-xs6qigg4	98	61	)	)	-RRB-
cord-002209-xs6qigg4	98	62	.	.	.
cord-002209-xs6qigg4	99	1	Therefore	therefore	RB
cord-002209-xs6qigg4	99	2	,	,	,
cord-002209-xs6qigg4	99	3	CNTF	CNTF	NNP
cord-002209-xs6qigg4	99	4	seems	seem	VBZ
cord-002209-xs6qigg4	99	5	to	to	TO
cord-002209-xs6qigg4	99	6	be	be	VB
cord-002209-xs6qigg4	99	7	an	an	DT
cord-002209-xs6qigg4	99	8	important	important	JJ
cord-002209-xs6qigg4	99	9	cytokine	cytokine	NN
cord-002209-xs6qigg4	99	10	involved	involve	VBN
cord-002209-xs6qigg4	99	11	in	in	IN
cord-002209-xs6qigg4	99	12	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	99	13	reactivity	reactivity	NN
cord-002209-xs6qigg4	99	14	and	and	CC
cord-002209-xs6qigg4	99	15	myelination	myelination	NN
cord-002209-xs6qigg4	99	16	.	.	.
cord-002209-xs6qigg4	100	1	Interestingly	interestingly	RB
cord-002209-xs6qigg4	100	2	,	,	,
cord-002209-xs6qigg4	100	3	IL-1β	il-1β	WRB
cord-002209-xs6qigg4	100	4	can	can	MD
cord-002209-xs6qigg4	100	5	also	also	RB
cord-002209-xs6qigg4	100	6	stimulate	stimulate	VB
cord-002209-xs6qigg4	100	7	the	the	DT
cord-002209-xs6qigg4	100	8	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	100	9	production	production	NN
cord-002209-xs6qigg4	100	10	of	of	IN
cord-002209-xs6qigg4	100	11	another	another	DT
cord-002209-xs6qigg4	100	12	IL-6	IL-6	NNP
cord-002209-xs6qigg4	100	13	family	family	NN
cord-002209-xs6qigg4	100	14	cytokine	cytokine	NN
cord-002209-xs6qigg4	100	15	,	,	,
cord-002209-xs6qigg4	100	16	LIF	LIF	NNP
cord-002209-xs6qigg4	100	17	,	,	,
cord-002209-xs6qigg4	100	18	(	(	-LRB-
cord-002209-xs6qigg4	100	19	Aloisi	Aloisi	NNP
cord-002209-xs6qigg4	100	20	et	et	NNP
cord-002209-xs6qigg4	100	21	al	al	NNP
cord-002209-xs6qigg4	100	22	.	.	NNP
cord-002209-xs6qigg4	100	23	,	,	,
cord-002209-xs6qigg4	100	24	1994	1994	CD
cord-002209-xs6qigg4	100	25	)	)	-RRB-
cord-002209-xs6qigg4	100	26	,	,	,
cord-002209-xs6qigg4	100	27	which	which	WDT
cord-002209-xs6qigg4	100	28	has	have	VBZ
cord-002209-xs6qigg4	100	29	been	be	VBN
cord-002209-xs6qigg4	100	30	shown	show	VBN
cord-002209-xs6qigg4	100	31	to	to	TO
cord-002209-xs6qigg4	100	32	promote	promote	VB
cord-002209-xs6qigg4	100	33	survival	survival	NN
cord-002209-xs6qigg4	100	34	and	and	CC
cord-002209-xs6qigg4	100	35	differentiation	differentiation	NN
cord-002209-xs6qigg4	100	36	of	of	IN
cord-002209-xs6qigg4	100	37	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	100	38	(	(	-LRB-
cord-002209-xs6qigg4	100	39	Khan	Khan	NNP
cord-002209-xs6qigg4	100	40	and	and	CC
cord-002209-xs6qigg4	100	41	De	De	NNP
cord-002209-xs6qigg4	100	42	Vellis	Vellis	NNP
cord-002209-xs6qigg4	100	43	,	,	,
cord-002209-xs6qigg4	100	44	1994	1994	CD
cord-002209-xs6qigg4	100	45	;	;	:
cord-002209-xs6qigg4	100	46	Mayer	Mayer	NNP
cord-002209-xs6qigg4	100	47	et	et	NNP
cord-002209-xs6qigg4	100	48	al	al	NNP
cord-002209-xs6qigg4	100	49	.	.	NNP
cord-002209-xs6qigg4	100	50	,	,	,
cord-002209-xs6qigg4	100	51	1994	1994	CD
cord-002209-xs6qigg4	100	52	;	;	:
cord-002209-xs6qigg4	100	53	Bugga	Bugga	NNP
cord-002209-xs6qigg4	100	54	et	et	NNP
cord-002209-xs6qigg4	100	55	al	al	NNP
cord-002209-xs6qigg4	100	56	.	.	NNP
cord-002209-xs6qigg4	100	57	,	,	,
cord-002209-xs6qigg4	100	58	1998	1998	CD
cord-002209-xs6qigg4	100	59	)	)	-RRB-
cord-002209-xs6qigg4	100	60	.	.	.
cord-002209-xs6qigg4	101	1	LIF	LIF	NNP
cord-002209-xs6qigg4	101	2	also	also	RB
cord-002209-xs6qigg4	101	3	decreases	decrease	VBZ
cord-002209-xs6qigg4	101	4	disease	disease	NN
cord-002209-xs6qigg4	101	5	severity	severity	NN
cord-002209-xs6qigg4	101	6	when	when	WRB
cord-002209-xs6qigg4	101	7	exogenously	exogenously	RB
cord-002209-xs6qigg4	101	8	administered	administer	VBN
cord-002209-xs6qigg4	101	9	in	in	IN
cord-002209-xs6qigg4	101	10	both	both	CC
cord-002209-xs6qigg4	101	11	chronic	chronic	JJ
cord-002209-xs6qigg4	101	12	and	and	CC
cord-002209-xs6qigg4	101	13	relapsing	relapse	VBG
cord-002209-xs6qigg4	101	14	-	-	HYPH
cord-002209-xs6qigg4	101	15	remitting	remit	VBG
cord-002209-xs6qigg4	101	16	EAE	EAE	NNP
cord-002209-xs6qigg4	101	17	mice	mouse	NNS
cord-002209-xs6qigg4	102	1	(	(	-LRB-
cord-002209-xs6qigg4	102	2	Aloisi	Aloisi	NNP
cord-002209-xs6qigg4	102	3	et	et	NNP
cord-002209-xs6qigg4	102	4	al	al	NNP
cord-002209-xs6qigg4	102	5	.	.	.
cord-002209-xs6qigg4	103	1	,	,	,
cord-002209-xs6qigg4	103	2	1994	1994	CD
cord-002209-xs6qigg4	103	3	;	;	:
cord-002209-xs6qigg4	103	4	Butzkueven	Butzkueven	NNP
cord-002209-xs6qigg4	103	5	et	et	NNP
cord-002209-xs6qigg4	103	6	al	al	NNP
cord-002209-xs6qigg4	103	7	.	.	.
cord-002209-xs6qigg4	104	1	,	,	,
cord-002209-xs6qigg4	104	2	2002	2002	CD
cord-002209-xs6qigg4	104	3	;	;	:
cord-002209-xs6qigg4	104	4	Ishibashi	Ishibashi	NNP
cord-002209-xs6qigg4	104	5	et	et	NNP
cord-002209-xs6qigg4	104	6	al	al	NNP
cord-002209-xs6qigg4	104	7	.	.	NNP
cord-002209-xs6qigg4	104	8	,	,	,
cord-002209-xs6qigg4	104	9	2006	2006	CD
cord-002209-xs6qigg4	104	10	)	)	-RRB-
cord-002209-xs6qigg4	104	11	.	.	.
cord-002209-xs6qigg4	105	1	Positive	positive	JJ
cord-002209-xs6qigg4	105	2	effects	effect	NNS
cord-002209-xs6qigg4	105	3	of	of	IN
cord-002209-xs6qigg4	105	4	LIF	LIF	NNP
cord-002209-xs6qigg4	105	5	on	on	IN
cord-002209-xs6qigg4	105	6	the	the	DT
cord-002209-xs6qigg4	105	7	survival	survival	NN
cord-002209-xs6qigg4	105	8	and	and	CC
cord-002209-xs6qigg4	105	9	maturation	maturation	NN
cord-002209-xs6qigg4	105	10	of	of	IN
cord-002209-xs6qigg4	105	11	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	105	12	also	also	RB
cord-002209-xs6qigg4	105	13	provides	provide	VBZ
cord-002209-xs6qigg4	105	14	evidence	evidence	NN
cord-002209-xs6qigg4	105	15	for	for	IN
cord-002209-xs6qigg4	105	16	the	the	DT
cord-002209-xs6qigg4	105	17	positive	positive	JJ
cord-002209-xs6qigg4	105	18	roles	role	NNS
cord-002209-xs6qigg4	105	19	of	of	IN
cord-002209-xs6qigg4	105	20	LIF	LIF	NNP
cord-002209-xs6qigg4	105	21	on	on	IN
cord-002209-xs6qigg4	105	22	myelination	myelination	NN
cord-002209-xs6qigg4	105	23	(	(	-LRB-
cord-002209-xs6qigg4	105	24	Khan	Khan	NNP
cord-002209-xs6qigg4	105	25	and	and	CC
cord-002209-xs6qigg4	105	26	De	De	NNP
cord-002209-xs6qigg4	105	27	Vellis	Vellis	NNP
cord-002209-xs6qigg4	105	28	,	,	,
cord-002209-xs6qigg4	105	29	1994	1994	CD
cord-002209-xs6qigg4	105	30	;	;	:
cord-002209-xs6qigg4	105	31	Mayer	Mayer	NNP
cord-002209-xs6qigg4	105	32	et	et	NNP
cord-002209-xs6qigg4	105	33	al	al	NNP
cord-002209-xs6qigg4	105	34	.	.	NNP
cord-002209-xs6qigg4	105	35	,	,	,
cord-002209-xs6qigg4	105	36	1994	1994	CD
cord-002209-xs6qigg4	105	37	;	;	:
cord-002209-xs6qigg4	105	38	Bugga	Bugga	NNP
cord-002209-xs6qigg4	105	39	et	et	NNP
cord-002209-xs6qigg4	105	40	al	al	NNP
cord-002209-xs6qigg4	105	41	.	.	NNP
cord-002209-xs6qigg4	105	42	,	,	,
cord-002209-xs6qigg4	105	43	1998	1998	CD
cord-002209-xs6qigg4	105	44	)	)	-RRB-
cord-002209-xs6qigg4	105	45	.	.	.
cord-002209-xs6qigg4	106	1	However	however	RB
cord-002209-xs6qigg4	106	2	,	,	,
cord-002209-xs6qigg4	106	3	other	other	JJ
cord-002209-xs6qigg4	106	4	pro	pro	JJ
cord-002209-xs6qigg4	106	5	-	-	JJ
cord-002209-xs6qigg4	106	6	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	106	7	cytokines	cytokine	NNS
cord-002209-xs6qigg4	106	8	such	such	JJ
cord-002209-xs6qigg4	106	9	as	as	IN
cord-002209-xs6qigg4	106	10	tumour	tumour	NN
cord-002209-xs6qigg4	106	11	necrosis	necrosis	NN
cord-002209-xs6qigg4	106	12	factoralpha	factoralpha	NNP
cord-002209-xs6qigg4	106	13	(	(	-LRB-
cord-002209-xs6qigg4	106	14	TNF	TNF	NNP
cord-002209-xs6qigg4	106	15	-	-	HYPH
cord-002209-xs6qigg4	106	16	α	α	NNP
cord-002209-xs6qigg4	106	17	)	)	-RRB-
cord-002209-xs6qigg4	106	18	and	and	CC
cord-002209-xs6qigg4	106	19	interferon	interferon	NN
cord-002209-xs6qigg4	106	20	-	-	HYPH
cord-002209-xs6qigg4	106	21	gamma	gamma	NN
cord-002209-xs6qigg4	106	22	(	(	-LRB-
cord-002209-xs6qigg4	106	23	IFN	IFN	NNP
cord-002209-xs6qigg4	106	24	-	-	HYPH
cord-002209-xs6qigg4	106	25	γ	γ	NNP
cord-002209-xs6qigg4	106	26	)	)	-RRB-
cord-002209-xs6qigg4	106	27	have	have	VBP
cord-002209-xs6qigg4	106	28	also	also	RB
cord-002209-xs6qigg4	106	29	been	be	VBN
cord-002209-xs6qigg4	106	30	shown	show	VBN
cord-002209-xs6qigg4	106	31	to	to	TO
cord-002209-xs6qigg4	106	32	potentiate	potentiate	VB
cord-002209-xs6qigg4	106	33	reactive	reactive	JJ
cord-002209-xs6qigg4	106	34	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	106	35	(	(	-LRB-
cord-002209-xs6qigg4	106	36	Yong	Yong	NNP
cord-002209-xs6qigg4	106	37	et	et	NNP
cord-002209-xs6qigg4	106	38	al	al	NNP
cord-002209-xs6qigg4	106	39	.	.	NNP
cord-002209-xs6qigg4	106	40	,	,	,
cord-002209-xs6qigg4	106	41	1991	1991	CD
cord-002209-xs6qigg4	106	42	John	John	NNP
cord-002209-xs6qigg4	106	43	et	et	NNP
cord-002209-xs6qigg4	106	44	al	al	NNP
cord-002209-xs6qigg4	106	45	.	.	NNP
cord-002209-xs6qigg4	106	46	,	,	,
cord-002209-xs6qigg4	106	47	2003	2003	CD
cord-002209-xs6qigg4	106	48	as	as	IN
cord-002209-xs6qigg4	106	49	discussed	discuss	VBN
cord-002209-xs6qigg4	106	50	below	below	RB
cord-002209-xs6qigg4	106	51	.	.	.
cord-002209-xs6qigg4	107	1	In	in	IN
cord-002209-xs6qigg4	107	2	contrast	contrast	NN
cord-002209-xs6qigg4	107	3	to	to	IN
cord-002209-xs6qigg4	107	4	their	-PRON-	PRP$
cord-002209-xs6qigg4	107	5	positive	positive	JJ
cord-002209-xs6qigg4	107	6	effects	effect	NNS
cord-002209-xs6qigg4	107	7	on	on	IN
cord-002209-xs6qigg4	107	8	myelination	myelination	NN
cord-002209-xs6qigg4	107	9	,	,	,
cord-002209-xs6qigg4	107	10	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	107	11	can	can	MD
cord-002209-xs6qigg4	107	12	also	also	RB
cord-002209-xs6qigg4	107	13	have	have	VB
cord-002209-xs6qigg4	107	14	a	a	DT
cord-002209-xs6qigg4	107	15	more	more	RBR
cord-002209-xs6qigg4	107	16	detrimental	detrimental	JJ
cord-002209-xs6qigg4	107	17	effect	effect	NN
cord-002209-xs6qigg4	107	18	on	on	IN
cord-002209-xs6qigg4	107	19	CNS	CNS	NNP
cord-002209-xs6qigg4	107	20	repair	repair	NN
cord-002209-xs6qigg4	107	21	via	via	IN
cord-002209-xs6qigg4	107	22	the	the	DT
cord-002209-xs6qigg4	107	23	secretion	secretion	NN
cord-002209-xs6qigg4	107	24	of	of	IN
cord-002209-xs6qigg4	107	25	chemokines	chemokine	NNS
cord-002209-xs6qigg4	107	26	/	/	SYM
cord-002209-xs6qigg4	107	27	cytokines	cytokine	NNS
cord-002209-xs6qigg4	107	28	when	when	WRB
cord-002209-xs6qigg4	107	29	in	in	IN
cord-002209-xs6qigg4	107	30	a	a	DT
cord-002209-xs6qigg4	107	31	more	more	RBR
cord-002209-xs6qigg4	107	32	severe	severe	JJ
cord-002209-xs6qigg4	107	33	,	,	,
cord-002209-xs6qigg4	107	34	reactive	reactive	JJ
cord-002209-xs6qigg4	107	35	state	state	NN
cord-002209-xs6qigg4	107	36	(	(	-LRB-
cord-002209-xs6qigg4	107	37	Fig	Fig	NNP
cord-002209-xs6qigg4	107	38	.	.	.
cord-002209-xs6qigg4	107	39	3	3	CD
cord-002209-xs6qigg4	107	40	)	)	-RRB-
cord-002209-xs6qigg4	107	41	.	.	.
cord-002209-xs6qigg4	108	1	One	one	CD
cord-002209-xs6qigg4	108	2	such	such	JJ
cord-002209-xs6qigg4	108	3	cytokine	cytokine	NN
cord-002209-xs6qigg4	108	4	is	be	VBZ
cord-002209-xs6qigg4	108	5	TNF	TNF	NNP
cord-002209-xs6qigg4	108	6	-	-	HYPH
cord-002209-xs6qigg4	108	7	α	α	NNP
cord-002209-xs6qigg4	108	8	,	,	,
cord-002209-xs6qigg4	108	9	which	which	WDT
cord-002209-xs6qigg4	108	10	has	have	VBZ
cord-002209-xs6qigg4	108	11	been	be	VBN
cord-002209-xs6qigg4	108	12	shown	show	VBN
cord-002209-xs6qigg4	108	13	to	to	TO
cord-002209-xs6qigg4	108	14	induce	induce	VB
cord-002209-xs6qigg4	108	15	myelin	myelin	NN
cord-002209-xs6qigg4	108	16	and	and	CC
cord-002209-xs6qigg4	108	17	oligodendrocyte	oligodendrocyte	JJ
cord-002209-xs6qigg4	108	18	damage	damage	NN
cord-002209-xs6qigg4	108	19	in	in	IN
cord-002209-xs6qigg4	108	20	vitro	vitro	FW
cord-002209-xs6qigg4	108	21	(	(	-LRB-
cord-002209-xs6qigg4	108	22	Selmaj	Selmaj	NNP
cord-002209-xs6qigg4	108	23	and	and	CC
cord-002209-xs6qigg4	108	24	Raine	Raine	NNP
cord-002209-xs6qigg4	108	25	,	,	,
cord-002209-xs6qigg4	108	26	1988	1988	CD
cord-002209-xs6qigg4	108	27	)	)	-RRB-
cord-002209-xs6qigg4	108	28	.	.	.
cord-002209-xs6qigg4	109	1	TNF	TNF	NNP
cord-002209-xs6qigg4	109	2	-	-	HYPH
cord-002209-xs6qigg4	109	3	α	α	NNP
cord-002209-xs6qigg4	109	4	mRNA	mrna	NN
cord-002209-xs6qigg4	109	5	expression	expression	NN
cord-002209-xs6qigg4	109	6	in	in	IN
cord-002209-xs6qigg4	109	7	MS	MS	NNP
cord-002209-xs6qigg4	109	8	plaques	plaque	NNS
cord-002209-xs6qigg4	109	9	positively	positively	RB
cord-002209-xs6qigg4	109	10	correlates	correlate	VBZ
cord-002209-xs6qigg4	109	11	with	with	IN
cord-002209-xs6qigg4	109	12	the	the	DT
cord-002209-xs6qigg4	109	13	extent	extent	NN
cord-002209-xs6qigg4	109	14	of	of	IN
cord-002209-xs6qigg4	109	15	demyelination	demyelination	NN
cord-002209-xs6qigg4	109	16	and	and	CC
cord-002209-xs6qigg4	109	17	has	have	VBZ
cord-002209-xs6qigg4	109	18	been	be	VBN
cord-002209-xs6qigg4	109	19	shown	show	VBN
cord-002209-xs6qigg4	109	20	to	to	TO
cord-002209-xs6qigg4	109	21	be	be	VB
cord-002209-xs6qigg4	109	22	present	present	JJ
cord-002209-xs6qigg4	109	23	in	in	IN
cord-002209-xs6qigg4	109	24	microglia	microglia	NNS
cord-002209-xs6qigg4	109	25	/	/	SYM
cord-002209-xs6qigg4	109	26	macrophages	macrophage	NNS
cord-002209-xs6qigg4	109	27	and	and	CC
cord-002209-xs6qigg4	109	28	to	to	IN
cord-002209-xs6qigg4	109	29	a	a	DT
cord-002209-xs6qigg4	109	30	smaller	small	JJR
cord-002209-xs6qigg4	109	31	percentage	percentage	NN
cord-002209-xs6qigg4	109	32	of	of	IN
cord-002209-xs6qigg4	109	33	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	110	1	(	(	-LRB-
cord-002209-xs6qigg4	110	2	Bitsch	Bitsch	NNP
cord-002209-xs6qigg4	110	3	et	et	NNP
cord-002209-xs6qigg4	110	4	al	al	NNP
cord-002209-xs6qigg4	110	5	.	.	NNP
cord-002209-xs6qigg4	110	6	,	,	,
cord-002209-xs6qigg4	110	7	2000	2000	CD
cord-002209-xs6qigg4	110	8	)	)	-RRB-
cord-002209-xs6qigg4	110	9	.	.	.
cord-002209-xs6qigg4	111	1	On	on	IN
cord-002209-xs6qigg4	111	2	the	the	DT
cord-002209-xs6qigg4	111	3	other	other	JJ
cord-002209-xs6qigg4	111	4	hand	hand	NN
cord-002209-xs6qigg4	111	5	,	,	,
cord-002209-xs6qigg4	111	6	studies	study	NNS
cord-002209-xs6qigg4	111	7	have	have	VBP
cord-002209-xs6qigg4	111	8	shown	show	VBN
cord-002209-xs6qigg4	111	9	TNF	TNF	NNP
cord-002209-xs6qigg4	111	10	-	-	HYPH
cord-002209-xs6qigg4	111	11	α	α	NNP
cord-002209-xs6qigg4	111	12	expression	expression	NN
cord-002209-xs6qigg4	111	13	is	be	VBZ
cord-002209-xs6qigg4	111	14	mainly	mainly	RB
cord-002209-xs6qigg4	111	15	associated	associate	VBN
cord-002209-xs6qigg4	111	16	with	with	IN
cord-002209-xs6qigg4	111	17	GFAP	GFAP	VBG
cord-002209-xs6qigg4	111	18	positive	positive	JJ
cord-002209-xs6qigg4	111	19	fibrous	fibrous	JJ
cord-002209-xs6qigg4	111	20	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	111	21	in	in	IN
cord-002209-xs6qigg4	111	22	chronic	chronic	JJ
cord-002209-xs6qigg4	111	23	active	active	JJ
cord-002209-xs6qigg4	111	24	MS	MS	NNP
cord-002209-xs6qigg4	111	25	lesions	lesion	NNS
cord-002209-xs6qigg4	111	26	at	at	IN
cord-002209-xs6qigg4	111	27	the	the	DT
cord-002209-xs6qigg4	111	28	lesion	lesion	NN
cord-002209-xs6qigg4	111	29	edge	edge	NN
cord-002209-xs6qigg4	111	30	(	(	-LRB-
cord-002209-xs6qigg4	112	1	Hofman	Hofman	NNP
cord-002209-xs6qigg4	112	2	et	et	NNP
cord-002209-xs6qigg4	112	3	al	al	NNP
cord-002209-xs6qigg4	112	4	.	.	NNP
cord-002209-xs6qigg4	112	5	,	,	,
cord-002209-xs6qigg4	112	6	1989	1989	CD
cord-002209-xs6qigg4	112	7	)	)	-RRB-
cord-002209-xs6qigg4	112	8	as	as	RB
cord-002209-xs6qigg4	112	9	well	well	RB
cord-002209-xs6qigg4	112	10	as	as	IN
cord-002209-xs6qigg4	112	11	foamy	foamy	JJ
cord-002209-xs6qigg4	112	12	macrophages	macrophage	NNS
cord-002209-xs6qigg4	112	13	and	and	CC
cord-002209-xs6qigg4	112	14	endothelial	endothelial	JJ
cord-002209-xs6qigg4	112	15	cells	cell	NNS
cord-002209-xs6qigg4	113	1	(	(	-LRB-
cord-002209-xs6qigg4	113	2	Selmaj	Selmaj	NNP
cord-002209-xs6qigg4	113	3	et	et	NNP
cord-002209-xs6qigg4	113	4	al	al	NNP
cord-002209-xs6qigg4	113	5	.	.	NNP
cord-002209-xs6qigg4	113	6	,	,	,
cord-002209-xs6qigg4	113	7	1991	1991	CD
cord-002209-xs6qigg4	113	8	)	)	-RRB-
cord-002209-xs6qigg4	113	9	.	.	.
cord-002209-xs6qigg4	114	1	However	however	RB
cord-002209-xs6qigg4	114	2	,	,	,
cord-002209-xs6qigg4	114	3	the	the	DT
cord-002209-xs6qigg4	114	4	fact	fact	NN
cord-002209-xs6qigg4	114	5	that	that	IN
cord-002209-xs6qigg4	114	6	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	114	7	appear	appear	VBP
cord-002209-xs6qigg4	114	8	as	as	IN
cord-002209-xs6qigg4	114	9	the	the	DT
cord-002209-xs6qigg4	114	10	major	major	JJ
cord-002209-xs6qigg4	114	11	or	or	CC
cord-002209-xs6qigg4	114	12	minor	minor	JJ
cord-002209-xs6qigg4	114	13	TNF	TNF	NNP
cord-002209-xs6qigg4	114	14	-	-	HYPH
cord-002209-xs6qigg4	114	15	α	α	NNP
cord-002209-xs6qigg4	114	16	expressing	express	VBG
cord-002209-xs6qigg4	114	17	cell	cell	NN
cord-002209-xs6qigg4	114	18	types	type	NNS
cord-002209-xs6qigg4	114	19	in	in	IN
cord-002209-xs6qigg4	114	20	MS	MS	NNP
cord-002209-xs6qigg4	114	21	lesions	lesion	NNS
cord-002209-xs6qigg4	114	22	might	may	MD
cord-002209-xs6qigg4	114	23	be	be	VB
cord-002209-xs6qigg4	114	24	because	because	IN
cord-002209-xs6qigg4	114	25	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	114	26	internalize	internalize	VBP
cord-002209-xs6qigg4	114	27	the	the	DT
cord-002209-xs6qigg4	114	28	protein	protein	NN
cord-002209-xs6qigg4	114	29	in	in	IN
cord-002209-xs6qigg4	114	30	a	a	DT
cord-002209-xs6qigg4	114	31	receptor	receptor	NN
cord-002209-xs6qigg4	114	32	-	-	HYPH
cord-002209-xs6qigg4	114	33	mediated	mediate	VBN
cord-002209-xs6qigg4	114	34	manner	manner	NN
cord-002209-xs6qigg4	115	1	(	(	-LRB-
cord-002209-xs6qigg4	115	2	Aránguez	Aránguez	NNP
cord-002209-xs6qigg4	115	3	et	et	FW
cord-002209-xs6qigg4	115	4	al	al	NNP
cord-002209-xs6qigg4	115	5	.	.	NNP
cord-002209-xs6qigg4	115	6	,	,	,
cord-002209-xs6qigg4	115	7	1995	1995	CD
cord-002209-xs6qigg4	115	8	;	;	:
cord-002209-xs6qigg4	115	9	Kuhlmann	Kuhlmann	NNP
cord-002209-xs6qigg4	115	10	et	et	NNP
cord-002209-xs6qigg4	115	11	al	al	NNP
cord-002209-xs6qigg4	115	12	.	.	NNP
cord-002209-xs6qigg4	115	13	,	,	,
cord-002209-xs6qigg4	115	14	2006	2006	CD
cord-002209-xs6qigg4	115	15	)	)	-RRB-
cord-002209-xs6qigg4	115	16	rather	rather	RB
cord-002209-xs6qigg4	115	17	than	than	IN
cord-002209-xs6qigg4	115	18	producing	produce	VBG
cord-002209-xs6qigg4	115	19	it	-PRON-	PRP
cord-002209-xs6qigg4	115	20	themselves	-PRON-	PRP
cord-002209-xs6qigg4	115	21	as	as	IN
cord-002209-xs6qigg4	115	22	suggested	suggest	VBN
cord-002209-xs6qigg4	115	23	by	by	IN
cord-002209-xs6qigg4	115	24	Hofman	Hofman	NNP
cord-002209-xs6qigg4	115	25	et	et	NNP
cord-002209-xs6qigg4	115	26	al	al	NNP
cord-002209-xs6qigg4	115	27	.	.	.
cord-002209-xs6qigg4	116	1	(	(	-LRB-
cord-002209-xs6qigg4	116	2	1989	1989	CD
cord-002209-xs6qigg4	116	3	)	)	-RRB-
cord-002209-xs6qigg4	116	4	and	and	CC
cord-002209-xs6qigg4	116	5	Bitsch	Bitsch	NNP
cord-002209-xs6qigg4	116	6	et	et	NNP
cord-002209-xs6qigg4	116	7	al	al	NNP
cord-002209-xs6qigg4	116	8	.	.	.
cord-002209-xs6qigg4	117	1	(	(	-LRB-
cord-002209-xs6qigg4	117	2	2000	2000	CD
cord-002209-xs6qigg4	117	3	)	)	-RRB-
cord-002209-xs6qigg4	117	4	.	.	.
cord-002209-xs6qigg4	118	1	Moreover	moreover	RB
cord-002209-xs6qigg4	118	2	,	,	,
cord-002209-xs6qigg4	118	3	it	-PRON-	PRP
cord-002209-xs6qigg4	118	4	is	be	VBZ
cord-002209-xs6qigg4	118	5	possible	possible	JJ
cord-002209-xs6qigg4	118	6	that	that	IN
cord-002209-xs6qigg4	118	7	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	118	8	require	require	VBP
cord-002209-xs6qigg4	118	9	a	a	DT
cord-002209-xs6qigg4	118	10	longer	long	JJR
cord-002209-xs6qigg4	118	11	period	period	NN
cord-002209-xs6qigg4	118	12	of	of	IN
cord-002209-xs6qigg4	118	13	time	time	NN
cord-002209-xs6qigg4	118	14	to	to	TO
cord-002209-xs6qigg4	118	15	become	become	VB
cord-002209-xs6qigg4	118	16	reactive	reactive	JJ
cord-002209-xs6qigg4	118	17	upon	upon	IN
cord-002209-xs6qigg4	118	18	injury	injury	NN
cord-002209-xs6qigg4	118	19	and	and	CC
cord-002209-xs6qigg4	118	20	only	only	RB
cord-002209-xs6qigg4	118	21	produce	produce	VB
cord-002209-xs6qigg4	118	22	TNF	TNF	NNP
cord-002209-xs6qigg4	118	23	-	-	HYPH
cord-002209-xs6qigg4	118	24	α	α	XX
cord-002209-xs6qigg4	118	25	first	first	RB
cord-002209-xs6qigg4	118	26	at	at	IN
cord-002209-xs6qigg4	118	27	the	the	DT
cord-002209-xs6qigg4	118	28	lesion	lesion	NN
cord-002209-xs6qigg4	118	29	edge	edge	NN
cord-002209-xs6qigg4	118	30	of	of	IN
cord-002209-xs6qigg4	118	31	acute	acute	JJ
cord-002209-xs6qigg4	118	32	MS	MS	NNP
cord-002209-xs6qigg4	118	33	plaques	plaque	NNS
cord-002209-xs6qigg4	118	34	and	and	CC
cord-002209-xs6qigg4	118	35	later	later	RB
cord-002209-xs6qigg4	118	36	both	both	CC
cord-002209-xs6qigg4	118	37	at	at	IN
cord-002209-xs6qigg4	118	38	the	the	DT
cord-002209-xs6qigg4	118	39	lesion	lesion	NN
cord-002209-xs6qigg4	118	40	edge	edge	NN
cord-002209-xs6qigg4	118	41	and	and	CC
cord-002209-xs6qigg4	118	42	in	in	IN
cord-002209-xs6qigg4	118	43	the	the	DT
cord-002209-xs6qigg4	118	44	lesion	lesion	NN
cord-002209-xs6qigg4	118	45	centre	centre	NN
cord-002209-xs6qigg4	118	46	of	of	IN
cord-002209-xs6qigg4	118	47	chronic	chronic	JJ
cord-002209-xs6qigg4	118	48	active	active	JJ
cord-002209-xs6qigg4	118	49	plaques	plaque	NNS
cord-002209-xs6qigg4	118	50	(	(	-LRB-
cord-002209-xs6qigg4	118	51	Selmaj	Selmaj	NNP
cord-002209-xs6qigg4	118	52	et	et	NNP
cord-002209-xs6qigg4	118	53	al	al	NNP
cord-002209-xs6qigg4	118	54	.	.	NNP
cord-002209-xs6qigg4	118	55	,	,	,
cord-002209-xs6qigg4	118	56	1991	1991	CD
cord-002209-xs6qigg4	118	57	)	)	-RRB-
cord-002209-xs6qigg4	118	58	.	.	.
cord-002209-xs6qigg4	119	1	In	in	IN
cord-002209-xs6qigg4	119	2	situ	situ	JJ
cord-002209-xs6qigg4	119	3	hybridisation	hybridisation	NN
cord-002209-xs6qigg4	119	4	for	for	IN
cord-002209-xs6qigg4	119	5	TNF	TNF	NNP
cord-002209-xs6qigg4	119	6	-	-	HYPH
cord-002209-xs6qigg4	119	7	α	α	NNP
cord-002209-xs6qigg4	119	8	mRNA	mrna	NN
cord-002209-xs6qigg4	119	9	has	have	VBZ
cord-002209-xs6qigg4	119	10	been	be	VBN
cord-002209-xs6qigg4	119	11	detected	detect	VBN
cord-002209-xs6qigg4	119	12	in	in	IN
cord-002209-xs6qigg4	119	13	GFAP	GFAP	NNP
cord-002209-xs6qigg4	119	14	-	-	HYPH
cord-002209-xs6qigg4	119	15	positive	positive	JJ
cord-002209-xs6qigg4	119	16	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	119	17	in	in	IN
cord-002209-xs6qigg4	119	18	mice	mouse	NNS
cord-002209-xs6qigg4	119	19	suffering	suffer	VBG
cord-002209-xs6qigg4	119	20	from	from	IN
cord-002209-xs6qigg4	119	21	pneumococcal	pneumococcal	JJ
cord-002209-xs6qigg4	119	22	meningitis	meningitis	NN
cord-002209-xs6qigg4	120	1	(	(	-LRB-
cord-002209-xs6qigg4	120	2	Izadpanah	Izadpanah	NNP
cord-002209-xs6qigg4	120	3	et	et	NNP
cord-002209-xs6qigg4	120	4	al	al	NNP
cord-002209-xs6qigg4	120	5	.	.	NNP
cord-002209-xs6qigg4	120	6	,	,	,
cord-002209-xs6qigg4	120	7	2014	2014	CD
cord-002209-xs6qigg4	120	8	)	)	-RRB-
cord-002209-xs6qigg4	120	9	which	which	WDT
cord-002209-xs6qigg4	120	10	also	also	RB
cord-002209-xs6qigg4	120	11	suggests	suggest	VBZ
cord-002209-xs6qigg4	120	12	that	that	IN
cord-002209-xs6qigg4	120	13	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	120	14	can	can	MD
cord-002209-xs6qigg4	120	15	indeed	indeed	RB
cord-002209-xs6qigg4	120	16	produce	produce	VB
cord-002209-xs6qigg4	120	17	TNF	TNF	NNP
cord-002209-xs6qigg4	120	18	-	-	HYPH
cord-002209-xs6qigg4	120	19	α	α	NN
cord-002209-xs6qigg4	120	20	in	in	IN
cord-002209-xs6qigg4	120	21	CNS	CNS	NNP
cord-002209-xs6qigg4	120	22	pathologies	pathology	NNS
cord-002209-xs6qigg4	120	23	.	.	.
cord-002209-xs6qigg4	121	1	Since	since	IN
cord-002209-xs6qigg4	121	2	TNF	TNF	NNP
cord-002209-xs6qigg4	121	3	-	-	HYPH
cord-002209-xs6qigg4	121	4	α	α	NN
cord-002209-xs6qigg4	121	5	effects	effect	NNS
cord-002209-xs6qigg4	121	6	the	the	DT
cord-002209-xs6qigg4	121	7	maturation	maturation	NN
cord-002209-xs6qigg4	121	8	of	of	IN
cord-002209-xs6qigg4	121	9	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	121	10	(	(	-LRB-
cord-002209-xs6qigg4	121	11	Cammer	Cammer	NNP
cord-002209-xs6qigg4	121	12	and	and	CC
cord-002209-xs6qigg4	121	13	Zhang	Zhang	NNP
cord-002209-xs6qigg4	121	14	,	,	,
cord-002209-xs6qigg4	121	15	1999	1999	CD
cord-002209-xs6qigg4	121	16	)	)	-RRB-
cord-002209-xs6qigg4	121	17	,	,	,
cord-002209-xs6qigg4	121	18	remyelination	remyelination	NN
cord-002209-xs6qigg4	121	19	failure	failure	NN
cord-002209-xs6qigg4	121	20	in	in	IN
cord-002209-xs6qigg4	121	21	the	the	DT
cord-002209-xs6qigg4	121	22	CNS	CNS	NNP
cord-002209-xs6qigg4	121	23	lesions	lesion	NNS
cord-002209-xs6qigg4	121	24	could	could	MD
cord-002209-xs6qigg4	121	25	be	be	VB
cord-002209-xs6qigg4	121	26	because	because	IN
cord-002209-xs6qigg4	121	27	TNF	TNF	NNP
cord-002209-xs6qigg4	121	28	-	-	HYPH
cord-002209-xs6qigg4	121	29	α	α	NNP
cord-002209-xs6qigg4	121	30	prevents	prevent	VBZ
cord-002209-xs6qigg4	121	31	the	the	DT
cord-002209-xs6qigg4	121	32	in	in	IN
cord-002209-xs6qigg4	121	33	situ	situ	JJ
cord-002209-xs6qigg4	121	34	differentiation	differentiation	NN
cord-002209-xs6qigg4	121	35	of	of	IN
cord-002209-xs6qigg4	121	36	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	121	37	.	.	.
cord-002209-xs6qigg4	122	1	Interestingly	interestingly	RB
cord-002209-xs6qigg4	122	2	,	,	,
cord-002209-xs6qigg4	122	3	direct	direct	JJ
cord-002209-xs6qigg4	122	4	cell	cell	NN
cord-002209-xs6qigg4	122	5	contact	contact	NN
cord-002209-xs6qigg4	122	6	between	between	IN
cord-002209-xs6qigg4	122	7	pre	pre	JJ
cord-002209-xs6qigg4	122	8	-	-	NNS
cord-002209-xs6qigg4	122	9	oligodendrocytes	oligodendrocytes	JJ
cord-002209-xs6qigg4	122	10	(	(	-LRB-
cord-002209-xs6qigg4	122	11	preOLs	preols	NN
cord-002209-xs6qigg4	122	12	)	)	-RRB-
cord-002209-xs6qigg4	122	13	and	and	CC
cord-002209-xs6qigg4	122	14	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	122	15	has	have	VBZ
cord-002209-xs6qigg4	122	16	been	be	VBN
cord-002209-xs6qigg4	122	17	shown	show	VBN
cord-002209-xs6qigg4	122	18	to	to	TO
cord-002209-xs6qigg4	122	19	be	be	VB
cord-002209-xs6qigg4	122	20	a	a	DT
cord-002209-xs6qigg4	122	21	prerequisite	prerequisite	NN
cord-002209-xs6qigg4	122	22	for	for	IN
cord-002209-xs6qigg4	122	23	TNF	TNF	NNP
cord-002209-xs6qigg4	122	24	to	to	TO
cord-002209-xs6qigg4	122	25	induce	induce	VB
cord-002209-xs6qigg4	122	26	apoptosis	apoptosis	NN
cord-002209-xs6qigg4	122	27	in	in	IN
cord-002209-xs6qigg4	122	28	preOLs	preols	NN
cord-002209-xs6qigg4	122	29	of	of	IN
cord-002209-xs6qigg4	122	30	rodent	rodent	NN
cord-002209-xs6qigg4	122	31	mixed	mixed	JJ
cord-002209-xs6qigg4	122	32	glial	glial	JJ
cord-002209-xs6qigg4	122	33	cultures	culture	NNS
cord-002209-xs6qigg4	123	1	(	(	-LRB-
cord-002209-xs6qigg4	123	2	Kim	Kim	NNP
cord-002209-xs6qigg4	123	3	et	et	NNP
cord-002209-xs6qigg4	123	4	al	al	NNP
cord-002209-xs6qigg4	123	5	.	.	NNP
cord-002209-xs6qigg4	123	6	,	,	,
cord-002209-xs6qigg4	123	7	2011	2011	CD
cord-002209-xs6qigg4	123	8	)	)	-RRB-
cord-002209-xs6qigg4	123	9	.	.	.
cord-002209-xs6qigg4	124	1	Nevertheless	nevertheless	RB
cord-002209-xs6qigg4	124	2	,	,	,
cord-002209-xs6qigg4	124	3	it	-PRON-	PRP
cord-002209-xs6qigg4	124	4	is	be	VBZ
cord-002209-xs6qigg4	124	5	possible	possible	JJ
cord-002209-xs6qigg4	124	6	that	that	IN
cord-002209-xs6qigg4	124	7	TNF	TNF	NNP
cord-002209-xs6qigg4	124	8	-	-	HYPH
cord-002209-xs6qigg4	124	9	α	α	NNP
cord-002209-xs6qigg4	124	10	increases	increase	VBZ
cord-002209-xs6qigg4	124	11	production	production	NN
cord-002209-xs6qigg4	124	12	of	of	IN
cord-002209-xs6qigg4	124	13	PDGF	PDGF	NNP
cord-002209-xs6qigg4	124	14	in	in	IN
cord-002209-xs6qigg4	124	15	demyelinated	demyelinated	JJ
cord-002209-xs6qigg4	124	16	spinal	spinal	JJ
cord-002209-xs6qigg4	124	17	cord	cord	NN
cord-002209-xs6qigg4	124	18	lesions	lesion	NNS
cord-002209-xs6qigg4	124	19	of	of	IN
cord-002209-xs6qigg4	124	20	MHV	MHV	NNP
cord-002209-xs6qigg4	124	21	-	-	HYPH
cord-002209-xs6qigg4	124	22	A59-injected	a59-injecte	VBN
cord-002209-xs6qigg4	124	23	mice	mouse	NNS
cord-002209-xs6qigg4	124	24	(	(	-LRB-
cord-002209-xs6qigg4	124	25	Redwine	Redwine	NNP
cord-002209-xs6qigg4	124	26	and	and	CC
cord-002209-xs6qigg4	124	27	Armstrong	Armstrong	NNP
cord-002209-xs6qigg4	124	28	,	,	,
cord-002209-xs6qigg4	124	29	1998	1998	CD
cord-002209-xs6qigg4	124	30	;	;	:
cord-002209-xs6qigg4	124	31	Frost	Frost	NNP
cord-002209-xs6qigg4	124	32	et	et	NNP
cord-002209-xs6qigg4	124	33	al	al	NNP
cord-002209-xs6qigg4	124	34	.	.	NNP
cord-002209-xs6qigg4	124	35	,	,	,
cord-002209-xs6qigg4	124	36	2003	2003	CD
cord-002209-xs6qigg4	124	37	)	)	-RRB-
cord-002209-xs6qigg4	124	38	as	as	IN
cord-002209-xs6qigg4	124	39	suggested	suggest	VBN
cord-002209-xs6qigg4	124	40	by	by	IN
cord-002209-xs6qigg4	124	41	the	the	DT
cord-002209-xs6qigg4	124	42	increase	increase	NN
cord-002209-xs6qigg4	124	43	of	of	IN
cord-002209-xs6qigg4	124	44	PDGF	PDGF	NNP
cord-002209-xs6qigg4	124	45	-	-	HYPH
cord-002209-xs6qigg4	124	46	β	β	NN
cord-002209-xs6qigg4	124	47	transcription	transcription	NN
cord-002209-xs6qigg4	124	48	and	and	CC
cord-002209-xs6qigg4	124	49	PDGF	PDGF	NNP
cord-002209-xs6qigg4	124	50	-	-	HYPH
cord-002209-xs6qigg4	124	51	αβ	αβ	NN
cord-002209-xs6qigg4	124	52	protein	protein	NN
cord-002209-xs6qigg4	124	53	levels	level	NNS
cord-002209-xs6qigg4	124	54	in	in	IN
cord-002209-xs6qigg4	124	55	embryonic	embryonic	JJ
cord-002209-xs6qigg4	124	56	human	human	JJ
cord-002209-xs6qigg4	124	57	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	124	58	upon	upon	IN
cord-002209-xs6qigg4	124	59	TNF	TNF	NNP
cord-002209-xs6qigg4	124	60	-	-	HYPH
cord-002209-xs6qigg4	124	61	α	α	NNP
cord-002209-xs6qigg4	124	62	treatment	treatment	NN
cord-002209-xs6qigg4	125	1	(	(	-LRB-
cord-002209-xs6qigg4	125	2	Silberstein	Silberstein	NNP
cord-002209-xs6qigg4	125	3	et	et	NNP
cord-002209-xs6qigg4	125	4	al	al	NNP
cord-002209-xs6qigg4	125	5	.	.	NNP
cord-002209-xs6qigg4	125	6	,	,	,
cord-002209-xs6qigg4	125	7	1996	1996	CD
cord-002209-xs6qigg4	125	8	)	)	-RRB-
cord-002209-xs6qigg4	125	9	.	.	.
cord-002209-xs6qigg4	126	1	Therefore	therefore	RB
cord-002209-xs6qigg4	126	2	,	,	,
cord-002209-xs6qigg4	126	3	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	126	4	might	may	MD
cord-002209-xs6qigg4	126	5	have	have	VB
cord-002209-xs6qigg4	126	6	a	a	DT
cord-002209-xs6qigg4	126	7	positive	positive	JJ
cord-002209-xs6qigg4	126	8	role	role	NN
cord-002209-xs6qigg4	126	9	on	on	IN
cord-002209-xs6qigg4	126	10	remyelination	remyelination	NN
cord-002209-xs6qigg4	126	11	both	both	CC
cord-002209-xs6qigg4	126	12	by	by	IN
cord-002209-xs6qigg4	126	13	producing	produce	VBG
cord-002209-xs6qigg4	126	14	TNF	TNF	NNP
cord-002209-xs6qigg4	126	15	-	-	HYPH
cord-002209-xs6qigg4	126	16	α	α	NNP
cord-002209-xs6qigg4	126	17	and	and	CC
cord-002209-xs6qigg4	126	18	by	by	IN
cord-002209-xs6qigg4	126	19	secreting	secrete	VBG
cord-002209-xs6qigg4	126	20	PDGF	PDGF	NNP
cord-002209-xs6qigg4	126	21	upon	upon	IN
cord-002209-xs6qigg4	126	22	stimulation	stimulation	NN
cord-002209-xs6qigg4	126	23	with	with	IN
cord-002209-xs6qigg4	126	24	TNF	TNF	NNP
cord-002209-xs6qigg4	126	25	-	-	HYPH
cord-002209-xs6qigg4	126	26	α	α	NNP
cord-002209-xs6qigg4	126	27	.	.	.
cord-002209-xs6qigg4	127	1	PDGF	PDGF	NNP
cord-002209-xs6qigg4	127	2	could	could	MD
cord-002209-xs6qigg4	127	3	in	in	IN
cord-002209-xs6qigg4	127	4	turn	turn	NN
cord-002209-xs6qigg4	127	5	support	support	VB
cord-002209-xs6qigg4	127	6	the	the	DT
cord-002209-xs6qigg4	127	7	survival	survival	NN
cord-002209-xs6qigg4	127	8	and	and	CC
cord-002209-xs6qigg4	127	9	enhance	enhance	VB
cord-002209-xs6qigg4	127	10	the	the	DT
cord-002209-xs6qigg4	127	11	proliferation	proliferation	NN
cord-002209-xs6qigg4	127	12	of	of	IN
cord-002209-xs6qigg4	127	13	OPCs	opc	NNS
cord-002209-xs6qigg4	127	14	in	in	IN
cord-002209-xs6qigg4	127	15	demyelinating	demyelinating	JJ
cord-002209-xs6qigg4	127	16	lesions	lesion	NNS
cord-002209-xs6qigg4	127	17	(	(	-LRB-
cord-002209-xs6qigg4	127	18	Woodruff	Woodruff	NNP
cord-002209-xs6qigg4	127	19	et	et	NNP
cord-002209-xs6qigg4	127	20	al	al	NNP
cord-002209-xs6qigg4	127	21	.	.	NNP
cord-002209-xs6qigg4	127	22	,	,	,
cord-002209-xs6qigg4	127	23	2004	2004	CD
cord-002209-xs6qigg4	127	24	;	;	:
cord-002209-xs6qigg4	128	1	Vana	Vana	NNP
cord-002209-xs6qigg4	128	2	et	et	NNP
cord-002209-xs6qigg4	128	3	al	al	NNP
cord-002209-xs6qigg4	128	4	.	.	NNP
cord-002209-xs6qigg4	128	5	,	,	,
cord-002209-xs6qigg4	128	6	2007	2007	CD
cord-002209-xs6qigg4	128	7	)	)	-RRB-
cord-002209-xs6qigg4	128	8	.	.	.
cord-002209-xs6qigg4	129	1	Consequently	consequently	RB
cord-002209-xs6qigg4	129	2	,	,	,
cord-002209-xs6qigg4	129	3	it	-PRON-	PRP
cord-002209-xs6qigg4	129	4	is	be	VBZ
cord-002209-xs6qigg4	129	5	yet	yet	RB
cord-002209-xs6qigg4	129	6	difficult	difficult	JJ
cord-002209-xs6qigg4	129	7	to	to	TO
cord-002209-xs6qigg4	129	8	conclude	conclude	VB
cord-002209-xs6qigg4	129	9	whether	whether	IN
cord-002209-xs6qigg4	129	10	reactive	reactive	JJ
cord-002209-xs6qigg4	129	11	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	129	12	associated	associate	VBN
cord-002209-xs6qigg4	129	13	with	with	IN
cord-002209-xs6qigg4	129	14	increased	increase	VBN
cord-002209-xs6qigg4	129	15	TNF	TNF	NNP
cord-002209-xs6qigg4	129	16	-	-	HYPH
cord-002209-xs6qigg4	129	17	α	α	NNP
cord-002209-xs6qigg4	129	18	levels	level	NNS
cord-002209-xs6qigg4	129	19	in	in	IN
cord-002209-xs6qigg4	129	20	CNS	CNS	NNP
cord-002209-xs6qigg4	129	21	lesions	lesion	NNS
cord-002209-xs6qigg4	129	22	are	be	VBP
cord-002209-xs6qigg4	129	23	predominantly	predominantly	RB
cord-002209-xs6qigg4	129	24	stimulatory	stimulatory	JJ
cord-002209-xs6qigg4	129	25	or	or	CC
cord-002209-xs6qigg4	129	26	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	129	27	to	to	IN
cord-002209-xs6qigg4	129	28	remyelination	remyelination	NN
cord-002209-xs6qigg4	129	29	.	.	.
cord-002209-xs6qigg4	130	1	IFN	IFN	NNP
cord-002209-xs6qigg4	130	2	-	-	HYPH
cord-002209-xs6qigg4	130	3	γ	γ	NNP
cord-002209-xs6qigg4	130	4	,	,	,
cord-002209-xs6qigg4	130	5	another	another	DT
cord-002209-xs6qigg4	130	6	cytokine	cytokine	NN
cord-002209-xs6qigg4	130	7	found	find	VBN
cord-002209-xs6qigg4	130	8	in	in	IN
cord-002209-xs6qigg4	130	9	MS	MS	NNP
cord-002209-xs6qigg4	130	10	plaques	plaque	NNS
cord-002209-xs6qigg4	130	11	,	,	,
cord-002209-xs6qigg4	130	12	has	have	VBZ
cord-002209-xs6qigg4	130	13	been	be	VBN
cord-002209-xs6qigg4	130	14	reported	report	VBN
cord-002209-xs6qigg4	130	15	to	to	IN
cord-002209-xs6qigg4	130	16	not	not	RB
cord-002209-xs6qigg4	130	17	only	only	RB
cord-002209-xs6qigg4	130	18	activate	activate	VB
cord-002209-xs6qigg4	130	19	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	130	20	,	,	,
cord-002209-xs6qigg4	130	21	but	but	CC
cord-002209-xs6qigg4	130	22	is	be	VBZ
cord-002209-xs6qigg4	130	23	also	also	RB
cord-002209-xs6qigg4	130	24	expressed	express	VBN
cord-002209-xs6qigg4	130	25	by	by	IN
cord-002209-xs6qigg4	130	26	reactive	reactive	JJ
cord-002209-xs6qigg4	130	27	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	130	28	and	and	CC
cord-002209-xs6qigg4	130	29	by	by	IN
cord-002209-xs6qigg4	130	30	immune	immune	JJ
cord-002209-xs6qigg4	130	31	cells	cell	NNS
cord-002209-xs6qigg4	130	32	that	that	WDT
cord-002209-xs6qigg4	130	33	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	130	34	have	have	VBP
cord-002209-xs6qigg4	130	35	stimulated	stimulate	VBN
cord-002209-xs6qigg4	130	36	(	(	-LRB-
cord-002209-xs6qigg4	130	37	Pulver	Pulver	NNP
cord-002209-xs6qigg4	130	38	et	et	NNP
cord-002209-xs6qigg4	130	39	al	al	NNP
cord-002209-xs6qigg4	130	40	.	.	NNP
cord-002209-xs6qigg4	130	41	,	,	,
cord-002209-xs6qigg4	130	42	1987	1987	CD
cord-002209-xs6qigg4	130	43	;	;	.
cord-002209-xs6qigg4	131	1	Traugott	Traugott	NNP
cord-002209-xs6qigg4	131	2	and	and	CC
cord-002209-xs6qigg4	131	3	Lebon	Lebon	NNP
cord-002209-xs6qigg4	131	4	,	,	,
cord-002209-xs6qigg4	131	5	1988	1988	CD
cord-002209-xs6qigg4	131	6	;	;	:
cord-002209-xs6qigg4	131	7	Miljkovic	Miljkovic	NNP
cord-002209-xs6qigg4	131	8	et	et	FW
cord-002209-xs6qigg4	131	9	al	al	NNP
cord-002209-xs6qigg4	131	10	.	.	NNP
cord-002209-xs6qigg4	131	11	,	,	,
cord-002209-xs6qigg4	131	12	2007	2007	CD
cord-002209-xs6qigg4	131	13	;	;	:
cord-002209-xs6qigg4	131	14	Hashioka	Hashioka	NNP
cord-002209-xs6qigg4	131	15	et	et	NNP
cord-002209-xs6qigg4	131	16	al	al	NNP
cord-002209-xs6qigg4	131	17	.	.	NNP
cord-002209-xs6qigg4	131	18	,	,	,
cord-002209-xs6qigg4	131	19	2009	2009	CD
cord-002209-xs6qigg4	131	20	;	;	:
cord-002209-xs6qigg4	131	21	Ionescu	Ionescu	NNP
cord-002209-xs6qigg4	131	22	et	et	NNP
cord-002209-xs6qigg4	131	23	al	al	NNP
cord-002209-xs6qigg4	131	24	.	.	NNP
cord-002209-xs6qigg4	131	25	,	,	,
cord-002209-xs6qigg4	131	26	2011	2011	CD
cord-002209-xs6qigg4	131	27	)	)	-RRB-
cord-002209-xs6qigg4	131	28	.	.	.
cord-002209-xs6qigg4	132	1	Similar	similar	JJ
cord-002209-xs6qigg4	132	2	to	to	IN
cord-002209-xs6qigg4	132	3	TNF	TNF	NNP
cord-002209-xs6qigg4	132	4	-	-	HYPH
cord-002209-xs6qigg4	132	5	α	α	NNP
cord-002209-xs6qigg4	132	6	,	,	,
cord-002209-xs6qigg4	132	7	IFN	IFN	NNP
cord-002209-xs6qigg4	132	8	-	-	HYPH
cord-002209-xs6qigg4	132	9	γ	γ	NNP
cord-002209-xs6qigg4	132	10	has	have	VBZ
cord-002209-xs6qigg4	132	11	been	be	VBN
cord-002209-xs6qigg4	132	12	shown	show	VBN
cord-002209-xs6qigg4	132	13	to	to	TO
cord-002209-xs6qigg4	132	14	suppress	suppress	VB
cord-002209-xs6qigg4	132	15	remyelination	remyelination	NN
cord-002209-xs6qigg4	132	16	and	and	CC
cord-002209-xs6qigg4	132	17	to	to	TO
cord-002209-xs6qigg4	132	18	delay	delay	VB
cord-002209-xs6qigg4	132	19	disease	disease	NN
cord-002209-xs6qigg4	132	20	recovery	recovery	NN
cord-002209-xs6qigg4	132	21	in	in	IN
cord-002209-xs6qigg4	132	22	transgenic	transgenic	JJ
cord-002209-xs6qigg4	132	23	EAE	EAE	NNP
cord-002209-xs6qigg4	132	24	mice	mouse	NNS
cord-002209-xs6qigg4	132	25	,	,	,
cord-002209-xs6qigg4	132	26	where	where	WRB
cord-002209-xs6qigg4	132	27	IFN	IFN	NNP
cord-002209-xs6qigg4	132	28	-	-	HYPH
cord-002209-xs6qigg4	132	29	γ	γ	NN
cord-002209-xs6qigg4	132	30	expression	expression	NN
cord-002209-xs6qigg4	132	31	by	by	IN
cord-002209-xs6qigg4	132	32	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	132	33	was	be	VBD
cord-002209-xs6qigg4	132	34	stimulated	stimulate	VBN
cord-002209-xs6qigg4	132	35	temporally	temporally	RB
cord-002209-xs6qigg4	132	36	in	in	IN
cord-002209-xs6qigg4	132	37	the	the	DT
cord-002209-xs6qigg4	132	38	recovery	recovery	NN
cord-002209-xs6qigg4	132	39	stage	stage	NN
cord-002209-xs6qigg4	132	40	(	(	-LRB-
cord-002209-xs6qigg4	132	41	Lin	Lin	NNP
cord-002209-xs6qigg4	132	42	et	et	NNP
cord-002209-xs6qigg4	132	43	al	al	NNP
cord-002209-xs6qigg4	132	44	.	.	NNP
cord-002209-xs6qigg4	132	45	,	,	,
cord-002209-xs6qigg4	132	46	2006	2006	CD
cord-002209-xs6qigg4	132	47	)	)	-RRB-
cord-002209-xs6qigg4	132	48	.	.	.
cord-002209-xs6qigg4	133	1	Astrocyte	Astrocyte	NNP
cord-002209-xs6qigg4	133	2	-	-	HYPH
cord-002209-xs6qigg4	133	3	directed	direct	VBN
cord-002209-xs6qigg4	133	4	expression	expression	NN
cord-002209-xs6qigg4	133	5	of	of	IN
cord-002209-xs6qigg4	133	6	IFN	IFN	NNP
cord-002209-xs6qigg4	133	7	-	-	HYPH
cord-002209-xs6qigg4	133	8	γ	γ	NNP
cord-002209-xs6qigg4	133	9	in	in	IN
cord-002209-xs6qigg4	133	10	transgenic	transgenic	JJ
cord-002209-xs6qigg4	133	11	mice	mouse	NNS
cord-002209-xs6qigg4	133	12	has	have	VBZ
cord-002209-xs6qigg4	133	13	also	also	RB
cord-002209-xs6qigg4	133	14	resulted	result	VBN
cord-002209-xs6qigg4	133	15	in	in	IN
cord-002209-xs6qigg4	133	16	regional	regional	JJ
cord-002209-xs6qigg4	133	17	hypomyelination	hypomyelination	NN
cord-002209-xs6qigg4	133	18	and	and	CC
cord-002209-xs6qigg4	133	19	selective	selective	JJ
cord-002209-xs6qigg4	133	20	disruption	disruption	NN
cord-002209-xs6qigg4	133	21	of	of	IN
cord-002209-xs6qigg4	133	22	brain	brain	NN
cord-002209-xs6qigg4	133	23	histogenesis	histogenesis	NN
cord-002209-xs6qigg4	133	24	,	,	,
cord-002209-xs6qigg4	133	25	which	which	WDT
cord-002209-xs6qigg4	133	26	led	lead	VBD
cord-002209-xs6qigg4	133	27	to	to	IN
cord-002209-xs6qigg4	133	28	ataxia	ataxia	NN
cord-002209-xs6qigg4	133	29	and	and	CC
cord-002209-xs6qigg4	133	30	shorter	short	JJR
cord-002209-xs6qigg4	133	31	life	life	NN
cord-002209-xs6qigg4	133	32	span	span	NN
cord-002209-xs6qigg4	133	33	(	(	-LRB-
cord-002209-xs6qigg4	133	34	LaFerla	LaFerla	NNP
cord-002209-xs6qigg4	133	35	et	et	NNP
cord-002209-xs6qigg4	133	36	al	al	NNP
cord-002209-xs6qigg4	133	37	.	.	NNP
cord-002209-xs6qigg4	133	38	,	,	,
cord-002209-xs6qigg4	133	39	2000	2000	CD
cord-002209-xs6qigg4	133	40	)	)	-RRB-
cord-002209-xs6qigg4	133	41	.	.	.
cord-002209-xs6qigg4	134	1	Furthermore	furthermore	RB
cord-002209-xs6qigg4	134	2	,	,	,
cord-002209-xs6qigg4	134	3	knocking	knock	VBG
cord-002209-xs6qigg4	134	4	down	down	RP
cord-002209-xs6qigg4	134	5	IFN	IFN	NNP
cord-002209-xs6qigg4	134	6	-	-	HYPH
cord-002209-xs6qigg4	134	7	γ	γ	NN
cord-002209-xs6qigg4	134	8	receptor	receptor	NN
cord-002209-xs6qigg4	134	9	expression	expression	NN
cord-002209-xs6qigg4	134	10	in	in	IN
cord-002209-xs6qigg4	134	11	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	134	12	three	three	CD
cord-002209-xs6qigg4	134	13	days	day	NNS
cord-002209-xs6qigg4	134	14	before	before	IN
cord-002209-xs6qigg4	134	15	immunization	immunization	NN
cord-002209-xs6qigg4	134	16	suppressed	suppress	VBD
cord-002209-xs6qigg4	134	17	EAE	EAE	NNP
cord-002209-xs6qigg4	134	18	and	and	CC
cord-002209-xs6qigg4	134	19	demyelination	demyelination	NN
cord-002209-xs6qigg4	134	20	by	by	IN
cord-002209-xs6qigg4	134	21	inhibiting	inhibit	VBG
cord-002209-xs6qigg4	134	22	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	134	23	cell	cell	NN
cord-002209-xs6qigg4	134	24	infiltration	infiltration	NN
cord-002209-xs6qigg4	134	25	(	(	-LRB-
cord-002209-xs6qigg4	134	26	Ding	Ding	NNP
cord-002209-xs6qigg4	134	27	et	et	FW
cord-002209-xs6qigg4	134	28	al	al	NNP
cord-002209-xs6qigg4	134	29	.	.	NNP
cord-002209-xs6qigg4	134	30	,	,	,
cord-002209-xs6qigg4	134	31	2015	2015	CD
cord-002209-xs6qigg4	134	32	)	)	-RRB-
cord-002209-xs6qigg4	134	33	.	.	.
cord-002209-xs6qigg4	135	1	These	these	DT
cord-002209-xs6qigg4	135	2	animals	animal	NNS
cord-002209-xs6qigg4	135	3	presented	present	VBD
cord-002209-xs6qigg4	135	4	lower	low	JJR
cord-002209-xs6qigg4	135	5	mean	mean	VB
cord-002209-xs6qigg4	135	6	clinical	clinical	JJ
cord-002209-xs6qigg4	135	7	scores	score	NNS
cord-002209-xs6qigg4	135	8	even	even	RB
cord-002209-xs6qigg4	135	9	when	when	WRB
cord-002209-xs6qigg4	135	10	the	the	DT
cord-002209-xs6qigg4	135	11	receptor	receptor	NN
cord-002209-xs6qigg4	135	12	silencing	silencing	NN
cord-002209-xs6qigg4	135	13	was	be	VBD
cord-002209-xs6qigg4	135	14	initiated	initiate	VBN
cord-002209-xs6qigg4	135	15	after	after	IN
cord-002209-xs6qigg4	135	16	disease	disease	NN
cord-002209-xs6qigg4	135	17	onset	onset	NN
cord-002209-xs6qigg4	135	18	or	or	CC
cord-002209-xs6qigg4	135	19	at	at	IN
cord-002209-xs6qigg4	135	20	disease	disease	NN
cord-002209-xs6qigg4	135	21	peak	peak	NN
cord-002209-xs6qigg4	136	1	(	(	-LRB-
cord-002209-xs6qigg4	136	2	Ding	Ding	NNP
cord-002209-xs6qigg4	136	3	et	et	FW
cord-002209-xs6qigg4	136	4	al	al	NNP
cord-002209-xs6qigg4	136	5	.	.	NNP
cord-002209-xs6qigg4	136	6	,	,	,
cord-002209-xs6qigg4	136	7	2015	2015	CD
cord-002209-xs6qigg4	136	8	)	)	-RRB-
cord-002209-xs6qigg4	136	9	.	.	.
cord-002209-xs6qigg4	137	1	Despite	despite	IN
cord-002209-xs6qigg4	137	2	the	the	DT
cord-002209-xs6qigg4	137	3	abovementioned	abovementioned	JJ
cord-002209-xs6qigg4	137	4	evidence	evidence	NN
cord-002209-xs6qigg4	137	5	suggesting	suggest	VBG
cord-002209-xs6qigg4	137	6	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	137	7	roles	role	NNS
cord-002209-xs6qigg4	137	8	for	for	IN
cord-002209-xs6qigg4	137	9	reactive	reactive	JJ
cord-002209-xs6qigg4	137	10	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	137	11	on	on	IN
cord-002209-xs6qigg4	137	12	myelination	myelination	NN
cord-002209-xs6qigg4	137	13	,	,	,
cord-002209-xs6qigg4	137	14	Hindinger	Hindinger	NNP
cord-002209-xs6qigg4	137	15	et	et	NNP
cord-002209-xs6qigg4	137	16	al	al	NNP
cord-002209-xs6qigg4	137	17	.	.	.
cord-002209-xs6qigg4	138	1	(	(	-LRB-
cord-002209-xs6qigg4	138	2	2012	2012	CD
cord-002209-xs6qigg4	138	3	)	)	-RRB-
cord-002209-xs6qigg4	138	4	have	have	VBP
cord-002209-xs6qigg4	138	5	proposed	propose	VBN
cord-002209-xs6qigg4	138	6	that	that	IN
cord-002209-xs6qigg4	138	7	IFN	IFN	NNP
cord-002209-xs6qigg4	138	8	-	-	HYPH
cord-002209-xs6qigg4	138	9	γ	γ	NNP
cord-002209-xs6qigg4	138	10	signalling	signal	VBG
cord-002209-xs6qigg4	138	11	in	in	IN
cord-002209-xs6qigg4	138	12	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	138	13	is	be	VBZ
cord-002209-xs6qigg4	138	14	indispensable	indispensable	JJ
cord-002209-xs6qigg4	138	15	for	for	IN
cord-002209-xs6qigg4	138	16	the	the	DT
cord-002209-xs6qigg4	138	17	alleviation	alleviation	NN
cord-002209-xs6qigg4	138	18	of	of	IN
cord-002209-xs6qigg4	138	19	EAE	EAE	NNP
cord-002209-xs6qigg4	138	20	since	since	IN
cord-002209-xs6qigg4	138	21	levels	level	NNS
cord-002209-xs6qigg4	138	22	of	of	IN
cord-002209-xs6qigg4	138	23	demyelination	demyelination	NN
cord-002209-xs6qigg4	138	24	and	and	CC
cord-002209-xs6qigg4	138	25	axonal	axonal	JJ
cord-002209-xs6qigg4	138	26	loss	loss	NN
cord-002209-xs6qigg4	138	27	are	be	VBP
cord-002209-xs6qigg4	138	28	increased	increase	VBN
cord-002209-xs6qigg4	138	29	during	during	IN
cord-002209-xs6qigg4	138	30	acute	acute	JJ
cord-002209-xs6qigg4	138	31	EAE	EAE	NNP
cord-002209-xs6qigg4	138	32	in	in	IN
cord-002209-xs6qigg4	138	33	mice	mouse	NNS
cord-002209-xs6qigg4	138	34	with	with	IN
cord-002209-xs6qigg4	138	35	an	an	DT
cord-002209-xs6qigg4	138	36	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	138	37	expression	expression	NN
cord-002209-xs6qigg4	138	38	of	of	IN
cord-002209-xs6qigg4	138	39	a	a	DT
cord-002209-xs6qigg4	138	40	dominant	dominant	JJ
cord-002209-xs6qigg4	138	41	negative	negative	JJ
cord-002209-xs6qigg4	138	42	allele	allele	NN
cord-002209-xs6qigg4	138	43	for	for	IN
cord-002209-xs6qigg4	138	44	IFN	IFN	NNP
cord-002209-xs6qigg4	138	45	-	-	HYPH
cord-002209-xs6qigg4	138	46	γ	γ	NN
cord-002209-xs6qigg4	138	47	receptor	receptor	NN
cord-002209-xs6qigg4	138	48	.	.	.
cord-002209-xs6qigg4	139	1	Nevertheless	nevertheless	RB
cord-002209-xs6qigg4	139	2	,	,	,
cord-002209-xs6qigg4	139	3	their	-PRON-	PRP$
cord-002209-xs6qigg4	139	4	approach	approach	NN
cord-002209-xs6qigg4	139	5	blocked	block	VBD
cord-002209-xs6qigg4	139	6	IFN	IFN	NNP
cord-002209-xs6qigg4	139	7	-	-	HYPH
cord-002209-xs6qigg4	139	8	γ	γ	NN
cord-002209-xs6qigg4	139	9	signalling	signal	VBG
cord-002209-xs6qigg4	139	10	in	in	IN
cord-002209-xs6qigg4	139	11	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	139	12	without	without	IN
cord-002209-xs6qigg4	139	13	decreasing	decrease	VBG
cord-002209-xs6qigg4	139	14	the	the	DT
cord-002209-xs6qigg4	139	15	expression	expression	NN
cord-002209-xs6qigg4	139	16	of	of	IN
cord-002209-xs6qigg4	139	17	IFN	IFN	NNP
cord-002209-xs6qigg4	139	18	-	-	HYPH
cord-002209-xs6qigg4	139	19	γ	γ	NNP
cord-002209-xs6qigg4	139	20	receptor	receptor	NN
cord-002209-xs6qigg4	139	21	,	,	,
cord-002209-xs6qigg4	139	22	which	which	WDT
cord-002209-xs6qigg4	139	23	would	would	MD
cord-002209-xs6qigg4	139	24	lower	lower	VB
cord-002209-xs6qigg4	139	25	the	the	DT
cord-002209-xs6qigg4	139	26	levels	level	NNS
cord-002209-xs6qigg4	139	27	of	of	IN
cord-002209-xs6qigg4	139	28	IFN	IFN	NNP
cord-002209-xs6qigg4	139	29	-	-	HYPH
cord-002209-xs6qigg4	139	30	γ	γ	NNP
cord-002209-xs6qigg4	139	31	available	available	JJ
cord-002209-xs6qigg4	139	32	for	for	IN
cord-002209-xs6qigg4	139	33	immunoregulatory	immunoregulatory	JJ
cord-002209-xs6qigg4	139	34	cells	cell	NNS
cord-002209-xs6qigg4	139	35	;	;	:
cord-002209-xs6qigg4	139	36	whereas	whereas	RB
cord-002209-xs6qigg4	139	37	,	,	,
cord-002209-xs6qigg4	139	38	Ding	Ding	NNP
cord-002209-xs6qigg4	139	39	et	et	FW
cord-002209-xs6qigg4	139	40	al	al	NNP
cord-002209-xs6qigg4	139	41	.	.	.
cord-002209-xs6qigg4	140	1	(	(	-LRB-
cord-002209-xs6qigg4	140	2	2015	2015	CD
cord-002209-xs6qigg4	140	3	)	)	-RRB-
cord-002209-xs6qigg4	140	4	have	have	VBP
cord-002209-xs6qigg4	140	5	knocked	knock	VBN
cord-002209-xs6qigg4	140	6	down	down	RP
cord-002209-xs6qigg4	140	7	the	the	DT
cord-002209-xs6qigg4	140	8	expression	expression	NN
cord-002209-xs6qigg4	140	9	of	of	IN
cord-002209-xs6qigg4	140	10	the	the	DT
cord-002209-xs6qigg4	140	11	receptor	receptor	NN
cord-002209-xs6qigg4	140	12	itself	-PRON-	PRP
cord-002209-xs6qigg4	140	13	.	.	.
cord-002209-xs6qigg4	141	1	Therefore	therefore	RB
cord-002209-xs6qigg4	141	2	,	,	,
cord-002209-xs6qigg4	141	3	blocking	block	VBG
cord-002209-xs6qigg4	141	4	or	or	CC
cord-002209-xs6qigg4	141	5	lowering	lower	VBG
cord-002209-xs6qigg4	141	6	IFN	IFN	NNP
cord-002209-xs6qigg4	141	7	-	-	HYPH
cord-002209-xs6qigg4	141	8	γ	γ	NN
cord-002209-xs6qigg4	141	9	signalling	signal	VBG
cord-002209-xs6qigg4	141	10	in	in	IN
cord-002209-xs6qigg4	141	11	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	141	12	with	with	IN
cord-002209-xs6qigg4	141	13	a	a	DT
cord-002209-xs6qigg4	141	14	carefully	carefully	RB
cord-002209-xs6qigg4	141	15	planned	plan	VBN
cord-002209-xs6qigg4	141	16	strategy	strategy	NN
cord-002209-xs6qigg4	141	17	might	may	MD
cord-002209-xs6qigg4	141	18	provide	provide	VB
cord-002209-xs6qigg4	141	19	new	new	JJ
cord-002209-xs6qigg4	141	20	disease	disease	NN
cord-002209-xs6qigg4	141	21	-	-	HYPH
cord-002209-xs6qigg4	141	22	modifying	modify	VBG
cord-002209-xs6qigg4	141	23	treatments	treatment	NNS
cord-002209-xs6qigg4	141	24	that	that	WDT
cord-002209-xs6qigg4	141	25	will	will	MD
cord-002209-xs6qigg4	141	26	limit	limit	VB
cord-002209-xs6qigg4	141	27	demyelination	demyelination	NN
cord-002209-xs6qigg4	141	28	.	.	.
cord-002209-xs6qigg4	142	1	Reactive	reactive	JJ
cord-002209-xs6qigg4	142	2	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	142	3	also	also	RB
cord-002209-xs6qigg4	142	4	secrete	secrete	VBP
cord-002209-xs6qigg4	142	5	C	c	NN
cord-002209-xs6qigg4	142	6	-	-	HYPH
cord-002209-xs6qigg4	142	7	X	x	NN
cord-002209-xs6qigg4	142	8	-	-	HYPH
cord-002209-xs6qigg4	142	9	C	c	NN
cord-002209-xs6qigg4	142	10	motif	motif	NN
cord-002209-xs6qigg4	142	11	chemokine	chemokine	NN
cord-002209-xs6qigg4	142	12	10	10	CD
cord-002209-xs6qigg4	142	13	(	(	-LRB-
cord-002209-xs6qigg4	142	14	CXCL10	CXCL10	NNP
cord-002209-xs6qigg4	142	15	,	,	,
cord-002209-xs6qigg4	142	16	Ransohoff	Ransohoff	NNP
cord-002209-xs6qigg4	142	17	et	et	NNP
cord-002209-xs6qigg4	142	18	al	al	NNP
cord-002209-xs6qigg4	142	19	.	.	NNP
cord-002209-xs6qigg4	142	20	,	,	,
cord-002209-xs6qigg4	142	21	1993	1993	CD
cord-002209-xs6qigg4	142	22	)	)	-RRB-
cord-002209-xs6qigg4	142	23	,	,	,
cord-002209-xs6qigg4	142	24	particularly	particularly	RB
cord-002209-xs6qigg4	142	25	around	around	IN
cord-002209-xs6qigg4	142	26	active	active	JJ
cord-002209-xs6qigg4	142	27	MS	MS	NNP
cord-002209-xs6qigg4	142	28	lesions	lesion	NNS
cord-002209-xs6qigg4	142	29	(	(	-LRB-
cord-002209-xs6qigg4	142	30	Omari	Omari	NNP
cord-002209-xs6qigg4	142	31	et	et	NNP
cord-002209-xs6qigg4	142	32	al	al	NNP
cord-002209-xs6qigg4	142	33	.	.	NNP
cord-002209-xs6qigg4	142	34	,	,	,
cord-002209-xs6qigg4	142	35	2005	2005	CD
cord-002209-xs6qigg4	142	36	;	;	:
cord-002209-xs6qigg4	142	37	Carter	Carter	NNP
cord-002209-xs6qigg4	142	38	et	et	NNP
cord-002209-xs6qigg4	142	39	al	al	NNP
cord-002209-xs6qigg4	142	40	.	.	NNP
cord-002209-xs6qigg4	142	41	,	,	,
cord-002209-xs6qigg4	142	42	2007	2007	CD
cord-002209-xs6qigg4	142	43	)	)	-RRB-
cord-002209-xs6qigg4	142	44	.	.	.
cord-002209-xs6qigg4	143	1	Cxcl10	Cxcl10	NNP
cord-002209-xs6qigg4	144	1	mRNA	mRNA	NNP
cord-002209-xs6qigg4	144	2	expression	expression	NN
cord-002209-xs6qigg4	144	3	increases	increase	VBZ
cord-002209-xs6qigg4	144	4	significantly	significantly	RB
cord-002209-xs6qigg4	144	5	during	during	IN
cord-002209-xs6qigg4	144	6	peak	peak	NN
cord-002209-xs6qigg4	144	7	disease	disease	NN
cord-002209-xs6qigg4	144	8	and	and	CC
cord-002209-xs6qigg4	144	9	decreases	decrease	NNS
cord-002209-xs6qigg4	144	10	during	during	IN
cord-002209-xs6qigg4	144	11	the	the	DT
cord-002209-xs6qigg4	144	12	recovery	recovery	NN
cord-002209-xs6qigg4	144	13	phases	phase	NNS
cord-002209-xs6qigg4	144	14	in	in	IN
cord-002209-xs6qigg4	144	15	animal	animal	NN
cord-002209-xs6qigg4	144	16	models	model	NNS
cord-002209-xs6qigg4	144	17	of	of	IN
cord-002209-xs6qigg4	144	18	MS	MS	NNP
cord-002209-xs6qigg4	144	19	(	(	-LRB-
cord-002209-xs6qigg4	144	20	Godiska	Godiska	NNP
cord-002209-xs6qigg4	144	21	et	et	NNP
cord-002209-xs6qigg4	144	22	al	al	NNP
cord-002209-xs6qigg4	144	23	.	.	NNP
cord-002209-xs6qigg4	144	24	,	,	,
cord-002209-xs6qigg4	144	25	1995	1995	CD
cord-002209-xs6qigg4	144	26	;	;	:
cord-002209-xs6qigg4	145	1	Glabinski	Glabinski	NNP
cord-002209-xs6qigg4	145	2	et	et	FW
cord-002209-xs6qigg4	145	3	al	al	NNP
cord-002209-xs6qigg4	145	4	.	.	NNP
cord-002209-xs6qigg4	145	5	,	,	,
cord-002209-xs6qigg4	145	6	1997	1997	CD
cord-002209-xs6qigg4	145	7	;	;	:
cord-002209-xs6qigg4	145	8	Fife	Fife	NNP
cord-002209-xs6qigg4	145	9	et	et	NNP
cord-002209-xs6qigg4	145	10	al	al	NNP
cord-002209-xs6qigg4	145	11	.	.	NNP
cord-002209-xs6qigg4	145	12	,	,	,
cord-002209-xs6qigg4	145	13	2001	2001	CD
cord-002209-xs6qigg4	145	14	)	)	-RRB-
cord-002209-xs6qigg4	145	15	.	.	.
cord-002209-xs6qigg4	146	1	A	a	DT
cord-002209-xs6qigg4	146	2	direct	direct	JJ
cord-002209-xs6qigg4	146	3	effect	effect	NN
cord-002209-xs6qigg4	146	4	of	of	IN
cord-002209-xs6qigg4	146	5	CXCL10	CXCL10	NNP
cord-002209-xs6qigg4	146	6	on	on	IN
cord-002209-xs6qigg4	146	7	the	the	DT
cord-002209-xs6qigg4	146	8	inhibition	inhibition	NN
cord-002209-xs6qigg4	146	9	of	of	IN
cord-002209-xs6qigg4	146	10	myelination	myelination	NN
cord-002209-xs6qigg4	146	11	was	be	VBD
cord-002209-xs6qigg4	146	12	shown	show	VBN
cord-002209-xs6qigg4	146	13	in	in	IN
cord-002209-xs6qigg4	146	14	dissociated	dissociated	JJ
cord-002209-xs6qigg4	146	15	rat	rat	NN
cord-002209-xs6qigg4	146	16	spinal	spinal	JJ
cord-002209-xs6qigg4	146	17	cord	cord	NN
cord-002209-xs6qigg4	146	18	cells	cell	NNS
cord-002209-xs6qigg4	146	19	plated	plate	VBN
cord-002209-xs6qigg4	146	20	on	on	IN
cord-002209-xs6qigg4	146	21	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	146	22	treated	treat	VBN
cord-002209-xs6qigg4	146	23	with	with	IN
cord-002209-xs6qigg4	146	24	CXCL10	CXCL10	NNP
cord-002209-xs6qigg4	146	25	and	and	CC
cord-002209-xs6qigg4	146	26	its	-PRON-	PRP$
cord-002209-xs6qigg4	146	27	neutralizing	neutralize	VBG
cord-002209-xs6qigg4	146	28	antibody	antibody	NN
cord-002209-xs6qigg4	146	29	.	.	.
cord-002209-xs6qigg4	147	1	In	in	IN
cord-002209-xs6qigg4	147	2	these	these	DT
cord-002209-xs6qigg4	147	3	experiments	experiment	NNS
cord-002209-xs6qigg4	147	4	CXCL10	cxcl10	CD
cord-002209-xs6qigg4	147	5	identified	identify	VBN
cord-002209-xs6qigg4	147	6	by	by	IN
cord-002209-xs6qigg4	147	7	microarray	microarray	NN
cord-002209-xs6qigg4	147	8	analysis	analysis	NN
cord-002209-xs6qigg4	147	9	,	,	,
cord-002209-xs6qigg4	147	10	was	be	VBD
cord-002209-xs6qigg4	147	11	upregulated	upregulate	VBN
cord-002209-xs6qigg4	147	12	in	in	IN
cord-002209-xs6qigg4	147	13	an	an	DT
cord-002209-xs6qigg4	147	14	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	147	15	phenotype	phenotype	NN
cord-002209-xs6qigg4	147	16	that	that	WDT
cord-002209-xs6qigg4	147	17	was	be	VBD
cord-002209-xs6qigg4	147	18	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	147	19	to	to	IN
cord-002209-xs6qigg4	147	20	CNS	cns	JJ
cord-002209-xs6qigg4	147	21	myelination	myelination	NN
cord-002209-xs6qigg4	147	22	in	in	IN
cord-002209-xs6qigg4	147	23	vitro	vitro	FW
cord-002209-xs6qigg4	147	24	.	.	.
cord-002209-xs6qigg4	148	1	Specifically	specifically	RB
cord-002209-xs6qigg4	148	2	,	,	,
cord-002209-xs6qigg4	148	3	CXCL10	CXCL10	NNP
cord-002209-xs6qigg4	148	4	appeared	appear	VBD
cord-002209-xs6qigg4	148	5	to	to	TO
cord-002209-xs6qigg4	148	6	inhibit	inhibit	VB
cord-002209-xs6qigg4	148	7	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	148	8	process	process	NN
cord-002209-xs6qigg4	148	9	extension	extension	NN
cord-002209-xs6qigg4	148	10	(	(	-LRB-
cord-002209-xs6qigg4	148	11	Nash	Nash	NNP
cord-002209-xs6qigg4	148	12	et	et	NNP
cord-002209-xs6qigg4	148	13	al	al	NNP
cord-002209-xs6qigg4	148	14	.	.	NNP
cord-002209-xs6qigg4	148	15	,	,	,
cord-002209-xs6qigg4	148	16	2011b	2011b	CD
cord-002209-xs6qigg4	148	17	)	)	-RRB-
cord-002209-xs6qigg4	148	18	.	.	.
cord-002209-xs6qigg4	149	1	Consequently	consequently	RB
cord-002209-xs6qigg4	149	2	,	,	,
cord-002209-xs6qigg4	149	3	cytokines	cytokine	NNS
cord-002209-xs6qigg4	149	4	stand	stand	VBP
cord-002209-xs6qigg4	149	5	out	out	RP
cord-002209-xs6qigg4	149	6	as	as	IN
cord-002209-xs6qigg4	149	7	an	an	DT
cord-002209-xs6qigg4	149	8	important	important	JJ
cord-002209-xs6qigg4	149	9	family	family	NN
cord-002209-xs6qigg4	149	10	of	of	IN
cord-002209-xs6qigg4	149	11	molecules	molecule	NNS
cord-002209-xs6qigg4	149	12	to	to	TO
cord-002209-xs6qigg4	149	13	activate	activate	VB
cord-002209-xs6qigg4	149	14	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	149	15	and	and	CC
cord-002209-xs6qigg4	149	16	to	to	TO
cord-002209-xs6qigg4	149	17	initiate	initiate	VB
cord-002209-xs6qigg4	149	18	different	different	JJ
cord-002209-xs6qigg4	149	19	forms	form	NNS
cord-002209-xs6qigg4	149	20	of	of	IN
cord-002209-xs6qigg4	149	21	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	149	22	reactivity	reactivity	NN
cord-002209-xs6qigg4	149	23	that	that	WDT
cord-002209-xs6qigg4	149	24	could	could	MD
cord-002209-xs6qigg4	149	25	be	be	VB
cord-002209-xs6qigg4	149	26	either	either	RB
cord-002209-xs6qigg4	149	27	beneficial	beneficial	JJ
cord-002209-xs6qigg4	149	28	or	or	CC
cord-002209-xs6qigg4	149	29	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	149	30	for	for	IN
cord-002209-xs6qigg4	149	31	the	the	DT
cord-002209-xs6qigg4	149	32	CNS	CNS	NNP
cord-002209-xs6qigg4	149	33	milieu	milieu	NN
cord-002209-xs6qigg4	149	34	in	in	IN
cord-002209-xs6qigg4	149	35	terms	term	NNS
cord-002209-xs6qigg4	149	36	of	of	IN
cord-002209-xs6qigg4	149	37	re	re	NN
cord-002209-xs6qigg4	149	38	/	/	NN
cord-002209-xs6qigg4	149	39	myelination	myelination	NN
cord-002209-xs6qigg4	149	40	.	.	.
cord-002209-xs6qigg4	150	1	It	-PRON-	PRP
cord-002209-xs6qigg4	150	2	should	should	MD
cord-002209-xs6qigg4	150	3	be	be	VB
cord-002209-xs6qigg4	150	4	noted	note	VBN
cord-002209-xs6qigg4	150	5	that	that	IN
cord-002209-xs6qigg4	150	6	the	the	DT
cord-002209-xs6qigg4	150	7	secretion	secretion	NN
cord-002209-xs6qigg4	150	8	of	of	IN
cord-002209-xs6qigg4	150	9	such	such	JJ
cord-002209-xs6qigg4	150	10	pro	pro	JJ
cord-002209-xs6qigg4	150	11	-	-	JJ
cord-002209-xs6qigg4	150	12	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	150	13	cytokines	cytokine	NNS
cord-002209-xs6qigg4	150	14	that	that	WDT
cord-002209-xs6qigg4	150	15	can	can	MD
cord-002209-xs6qigg4	150	16	contribute	contribute	VB
cord-002209-xs6qigg4	150	17	to	to	IN
cord-002209-xs6qigg4	150	18	the	the	DT
cord-002209-xs6qigg4	150	19	lack	lack	NN
cord-002209-xs6qigg4	150	20	of	of	IN
cord-002209-xs6qigg4	150	21	remyelination	remyelination	NN
cord-002209-xs6qigg4	150	22	within	within	IN
cord-002209-xs6qigg4	150	23	MS	MS	NNP
cord-002209-xs6qigg4	150	24	plaques	plaque	NNS
cord-002209-xs6qigg4	150	25	is	be	VBZ
cord-002209-xs6qigg4	150	26	not	not	RB
cord-002209-xs6qigg4	150	27	restricted	restrict	VBN
cord-002209-xs6qigg4	150	28	to	to	IN
cord-002209-xs6qigg4	150	29	reactive	reactive	JJ
cord-002209-xs6qigg4	150	30	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	150	31	since	since	IN
cord-002209-xs6qigg4	150	32	other	other	JJ
cord-002209-xs6qigg4	150	33	glial	glial	NN
cord-002209-xs6qigg4	150	34	and	and	CC
cord-002209-xs6qigg4	150	35	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	150	36	cell	cell	NN
cord-002209-xs6qigg4	150	37	types	type	NNS
cord-002209-xs6qigg4	150	38	will	will	MD
cord-002209-xs6qigg4	150	39	also	also	RB
cord-002209-xs6qigg4	150	40	secrete	secrete	VB
cord-002209-xs6qigg4	150	41	them	-PRON-	PRP
cord-002209-xs6qigg4	150	42	.	.	.
cord-002209-xs6qigg4	151	1	Moreover	moreover	RB
cord-002209-xs6qigg4	151	2	,	,	,
cord-002209-xs6qigg4	151	3	the	the	DT
cord-002209-xs6qigg4	151	4	up	up	JJ
cord-002209-xs6qigg4	151	5	regulation	regulation	NN
cord-002209-xs6qigg4	151	6	of	of	IN
cord-002209-xs6qigg4	151	7	such	such	JJ
cord-002209-xs6qigg4	151	8	cytokines	cytokine	NNS
cord-002209-xs6qigg4	151	9	by	by	IN
cord-002209-xs6qigg4	151	10	reactive	reactive	JJ
cord-002209-xs6qigg4	151	11	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	151	12	can	can	MD
cord-002209-xs6qigg4	151	13	also	also	RB
cord-002209-xs6qigg4	151	14	be	be	VB
cord-002209-xs6qigg4	151	15	protective	protective	JJ
cord-002209-xs6qigg4	151	16	for	for	IN
cord-002209-xs6qigg4	151	17	CNS	CNS	NNP
cord-002209-xs6qigg4	151	18	injury	injury	NN
cord-002209-xs6qigg4	151	19	.	.	.
cord-002209-xs6qigg4	152	1	For	for	IN
cord-002209-xs6qigg4	152	2	example	example	NN
cord-002209-xs6qigg4	152	3	,	,	,
cord-002209-xs6qigg4	152	4	the	the	DT
cord-002209-xs6qigg4	152	5	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	152	6	scar	scar	NN
cord-002209-xs6qigg4	152	7	can	can	MD
cord-002209-xs6qigg4	152	8	restrict	restrict	VB
cord-002209-xs6qigg4	152	9	leukocyte	leukocyte	NN
cord-002209-xs6qigg4	152	10	migration	migration	NN
cord-002209-xs6qigg4	152	11	from	from	IN
cord-002209-xs6qigg4	152	12	within	within	IN
cord-002209-xs6qigg4	152	13	areas	area	NNS
cord-002209-xs6qigg4	152	14	of	of	IN
cord-002209-xs6qigg4	152	15	damaged	damaged	JJ
cord-002209-xs6qigg4	152	16	tissue	tissue	NN
cord-002209-xs6qigg4	152	17	into	into	IN
cord-002209-xs6qigg4	152	18	the	the	DT
cord-002209-xs6qigg4	152	19	otherwise	otherwise	RB
cord-002209-xs6qigg4	152	20	healthy	healthy	JJ
cord-002209-xs6qigg4	152	21	non	non	JJ
cord-002209-xs6qigg4	152	22	damaged	damaged	JJ
cord-002209-xs6qigg4	152	23	CNS	CNS	NNP
cord-002209-xs6qigg4	152	24	tissue	tissue	NN
cord-002209-xs6qigg4	152	25	in	in	IN
cord-002209-xs6qigg4	152	26	close	close	JJ
cord-002209-xs6qigg4	152	27	proximity	proximity	NN
cord-002209-xs6qigg4	152	28	to	to	IN
cord-002209-xs6qigg4	152	29	the	the	DT
cord-002209-xs6qigg4	152	30	scar	scar	NN
cord-002209-xs6qigg4	152	31	protecting	protect	VBG
cord-002209-xs6qigg4	152	32	it	-PRON-	PRP
cord-002209-xs6qigg4	152	33	from	from	IN
cord-002209-xs6qigg4	152	34	immune	immune	JJ
cord-002209-xs6qigg4	152	35	mediated	mediate	VBN
cord-002209-xs6qigg4	152	36	damage	damage	NN
cord-002209-xs6qigg4	153	1	(	(	-LRB-
cord-002209-xs6qigg4	153	2	Faulkner	Faulkner	NNP
cord-002209-xs6qigg4	153	3	et	et	NNP
cord-002209-xs6qigg4	153	4	al	al	NNP
cord-002209-xs6qigg4	153	5	.	.	NNP
cord-002209-xs6qigg4	153	6	,	,	,
cord-002209-xs6qigg4	153	7	2004	2004	CD
cord-002209-xs6qigg4	154	1	;	;	:
cord-002209-xs6qigg4	154	2	Okada	Okada	NNP
cord-002209-xs6qigg4	154	3	et	et	NNP
cord-002209-xs6qigg4	154	4	al	al	NNP
cord-002209-xs6qigg4	154	5	.	.	NNP
cord-002209-xs6qigg4	154	6	,	,	,
cord-002209-xs6qigg4	154	7	2006	2006	CD
cord-002209-xs6qigg4	154	8	;	;	:
cord-002209-xs6qigg4	154	9	Herrmann	Herrmann	NNP
cord-002209-xs6qigg4	154	10	et	et	NNP
cord-002209-xs6qigg4	154	11	al	al	NNP
cord-002209-xs6qigg4	154	12	.	.	NNP
cord-002209-xs6qigg4	154	13	,	,	,
cord-002209-xs6qigg4	154	14	2008	2008	CD
cord-002209-xs6qigg4	155	1	;	;	:
cord-002209-xs6qigg4	155	2	Voskuhl	Voskuhl	NNP
cord-002209-xs6qigg4	155	3	et	et	NNP
cord-002209-xs6qigg4	155	4	al	al	NNP
cord-002209-xs6qigg4	155	5	.	.	NNP
cord-002209-xs6qigg4	155	6	,	,	,
cord-002209-xs6qigg4	155	7	2009	2009	CD
cord-002209-xs6qigg4	155	8	)	)	-RRB-
cord-002209-xs6qigg4	155	9	.	.	.
cord-002209-xs6qigg4	156	1	A	a	DT
cord-002209-xs6qigg4	156	2	vital	vital	JJ
cord-002209-xs6qigg4	156	3	supportive	supportive	JJ
cord-002209-xs6qigg4	156	4	role	role	NN
cord-002209-xs6qigg4	156	5	played	play	VBN
cord-002209-xs6qigg4	156	6	by	by	IN
cord-002209-xs6qigg4	156	7	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	156	8	following	follow	VBG
cord-002209-xs6qigg4	156	9	injury	injury	NN
cord-002209-xs6qigg4	156	10	is	be	VBZ
cord-002209-xs6qigg4	156	11	the	the	DT
cord-002209-xs6qigg4	156	12	provision	provision	NN
cord-002209-xs6qigg4	156	13	of	of	IN
cord-002209-xs6qigg4	156	14	an	an	DT
cord-002209-xs6qigg4	156	15	energy	energy	NN
cord-002209-xs6qigg4	156	16	source	source	NN
cord-002209-xs6qigg4	156	17	,	,	,
cord-002209-xs6qigg4	156	18	which	which	WDT
cord-002209-xs6qigg4	156	19	is	be	VBZ
cord-002209-xs6qigg4	156	20	important	important	JJ
cord-002209-xs6qigg4	156	21	if	if	IN
cord-002209-xs6qigg4	156	22	axons	axon	NNS
cord-002209-xs6qigg4	156	23	are	be	VBP
cord-002209-xs6qigg4	156	24	to	to	TO
cord-002209-xs6qigg4	156	25	be	be	VB
cord-002209-xs6qigg4	156	26	myelinated	myelinated	JJ
cord-002209-xs6qigg4	156	27	.	.	.
cord-002209-xs6qigg4	157	1	This	this	DT
cord-002209-xs6qigg4	157	2	energy	energy	NN
cord-002209-xs6qigg4	157	3	is	be	VBZ
cord-002209-xs6qigg4	157	4	metabolized	metabolize	VBN
cord-002209-xs6qigg4	157	5	from	from	IN
cord-002209-xs6qigg4	157	6	glucose	glucose	NN
cord-002209-xs6qigg4	157	7	which	which	WDT
cord-002209-xs6qigg4	157	8	enters	enter	VBZ
cord-002209-xs6qigg4	157	9	the	the	DT
cord-002209-xs6qigg4	157	10	brain	brain	NN
cord-002209-xs6qigg4	157	11	via	via	IN
cord-002209-xs6qigg4	157	12	the	the	DT
cord-002209-xs6qigg4	157	13	endothelial	endothelial	JJ
cord-002209-xs6qigg4	157	14	cells	cell	NNS
cord-002209-xs6qigg4	157	15	lining	line	VBG
cord-002209-xs6qigg4	157	16	the	the	DT
cord-002209-xs6qigg4	157	17	blood	blood	NN
cord-002209-xs6qigg4	157	18	brain	brain	NN
cord-002209-xs6qigg4	157	19	barrier	barrier	NN
cord-002209-xs6qigg4	157	20	(	(	-LRB-
cord-002209-xs6qigg4	157	21	BBB	BBB	NNP
cord-002209-xs6qigg4	157	22	)	)	-RRB-
cord-002209-xs6qigg4	157	23	,	,	,
cord-002209-xs6qigg4	157	24	which	which	WDT
cord-002209-xs6qigg4	157	25	are	be	VBP
cord-002209-xs6qigg4	157	26	in	in	IN
cord-002209-xs6qigg4	157	27	close	close	JJ
cord-002209-xs6qigg4	157	28	contact	contact	NN
cord-002209-xs6qigg4	157	29	with	with	IN
cord-002209-xs6qigg4	157	30	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	157	31	.	.	.
cord-002209-xs6qigg4	158	1	Unlike	unlike	IN
cord-002209-xs6qigg4	158	2	endothelial	endothelial	JJ
cord-002209-xs6qigg4	158	3	cells	cell	NNS
cord-002209-xs6qigg4	158	4	,	,	,
cord-002209-xs6qigg4	158	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	158	6	biochemically	biochemically	RB
cord-002209-xs6qigg4	158	7	transform	transform	VBP
cord-002209-xs6qigg4	158	8	glucose	glucose	NN
cord-002209-xs6qigg4	158	9	into	into	IN
cord-002209-xs6qigg4	158	10	glycogen	glycogen	NN
cord-002209-xs6qigg4	158	11	,	,	,
cord-002209-xs6qigg4	158	12	the	the	DT
cord-002209-xs6qigg4	158	13	principal	principal	JJ
cord-002209-xs6qigg4	158	14	source	source	NN
cord-002209-xs6qigg4	158	15	of	of	IN
cord-002209-xs6qigg4	158	16	stored	store	VBN
cord-002209-xs6qigg4	158	17	energy	energy	NN
cord-002209-xs6qigg4	158	18	in	in	IN
cord-002209-xs6qigg4	158	19	all	all	DT
cord-002209-xs6qigg4	158	20	cell	cell	NN
cord-002209-xs6qigg4	158	21	types	type	NNS
cord-002209-xs6qigg4	158	22	(	(	-LRB-
cord-002209-xs6qigg4	158	23	Pellegri	Pellegri	NNP
cord-002209-xs6qigg4	158	24	et	et	FW
cord-002209-xs6qigg4	158	25	al	al	NNP
cord-002209-xs6qigg4	158	26	.	.	NNP
cord-002209-xs6qigg4	158	27	,	,	,
cord-002209-xs6qigg4	158	28	1996	1996	CD
cord-002209-xs6qigg4	158	29	;	;	.
cord-002209-xs6qigg4	159	1	Pfeiffer	Pfeiffer	NNP
cord-002209-xs6qigg4	159	2	-	-	HYPH
cord-002209-xs6qigg4	159	3	Guglielmi	Guglielmi	NNP
cord-002209-xs6qigg4	159	4	et	et	NNP
cord-002209-xs6qigg4	159	5	al	al	NNP
cord-002209-xs6qigg4	159	6	.	.	NNP
cord-002209-xs6qigg4	159	7	,	,	,
cord-002209-xs6qigg4	159	8	2003	2003	CD
cord-002209-xs6qigg4	159	9	)	)	-RRB-
cord-002209-xs6qigg4	159	10	.	.	.
cord-002209-xs6qigg4	160	1	In	in	IN
cord-002209-xs6qigg4	160	2	addition	addition	NN
cord-002209-xs6qigg4	160	3	,	,	,
cord-002209-xs6qigg4	160	4	it	-PRON-	PRP
cord-002209-xs6qigg4	160	5	has	have	VBZ
cord-002209-xs6qigg4	160	6	been	be	VBN
cord-002209-xs6qigg4	160	7	suggested	suggest	VBN
cord-002209-xs6qigg4	160	8	that	that	IN
cord-002209-xs6qigg4	160	9	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	160	10	under	under	IN
cord-002209-xs6qigg4	160	11	low	low	JJ
cord-002209-xs6qigg4	160	12	glucose	glucose	NN
cord-002209-xs6qigg4	160	13	concentrations	concentration	NNS
cord-002209-xs6qigg4	160	14	can	can	MD
cord-002209-xs6qigg4	160	15	degrade	degrade	VB
cord-002209-xs6qigg4	160	16	stored	store	VBN
cord-002209-xs6qigg4	160	17	glycogen	glycogen	NN
cord-002209-xs6qigg4	160	18	into	into	IN
cord-002209-xs6qigg4	160	19	lactate	lactate	NN
cord-002209-xs6qigg4	160	20	which	which	WDT
cord-002209-xs6qigg4	160	21	in	in	IN
cord-002209-xs6qigg4	160	22	turn	turn	NN
cord-002209-xs6qigg4	160	23	increases	increase	VBZ
cord-002209-xs6qigg4	160	24	extracellular	extracellular	JJ
cord-002209-xs6qigg4	160	25	lactate	lactate	NN
cord-002209-xs6qigg4	160	26	levels	level	NNS
cord-002209-xs6qigg4	160	27	to	to	TO
cord-002209-xs6qigg4	160	28	provide	provide	VB
cord-002209-xs6qigg4	160	29	energy	energy	NN
cord-002209-xs6qigg4	160	30	for	for	IN
cord-002209-xs6qigg4	160	31	nearby	nearby	JJ
cord-002209-xs6qigg4	160	32	axons	axon	NNS
cord-002209-xs6qigg4	160	33	when	when	WRB
cord-002209-xs6qigg4	160	34	deprivation	deprivation	NN
cord-002209-xs6qigg4	160	35	occurs	occur	VBZ
cord-002209-xs6qigg4	160	36	after	after	IN
cord-002209-xs6qigg4	160	37	injury	injury	NN
cord-002209-xs6qigg4	161	1	(	(	-LRB-
cord-002209-xs6qigg4	161	2	Tekkök	Tekkök	NNP
cord-002209-xs6qigg4	161	3	et	et	FW
cord-002209-xs6qigg4	161	4	al	al	NNP
cord-002209-xs6qigg4	161	5	.	.	NNP
cord-002209-xs6qigg4	161	6	,	,	,
cord-002209-xs6qigg4	161	7	2005	2005	CD
cord-002209-xs6qigg4	161	8	)	)	-RRB-
cord-002209-xs6qigg4	161	9	.	.	.
cord-002209-xs6qigg4	162	1	The	the	DT
cord-002209-xs6qigg4	162	2	lactate	lactate	NN
cord-002209-xs6qigg4	162	3	derived	derive	VBN
cord-002209-xs6qigg4	162	4	from	from	IN
cord-002209-xs6qigg4	162	5	astroglial	astroglial	JJ
cord-002209-xs6qigg4	162	6	glycogen	glycogen	NN
cord-002209-xs6qigg4	162	7	via	via	IN
cord-002209-xs6qigg4	162	8	glycolysis	glycolysis	NN
cord-002209-xs6qigg4	162	9	is	be	VBZ
cord-002209-xs6qigg4	162	10	transferred	transfer	VBN
cord-002209-xs6qigg4	162	11	directly	directly	RB
cord-002209-xs6qigg4	162	12	to	to	IN
cord-002209-xs6qigg4	162	13	the	the	DT
cord-002209-xs6qigg4	162	14	axon	axon	NN
cord-002209-xs6qigg4	162	15	at	at	IN
cord-002209-xs6qigg4	162	16	the	the	DT
cord-002209-xs6qigg4	162	17	node	node	NN
cord-002209-xs6qigg4	162	18	of	of	IN
cord-002209-xs6qigg4	162	19	Ranvier	Ranvier	NNP
cord-002209-xs6qigg4	162	20	(	(	-LRB-
cord-002209-xs6qigg4	162	21	Hirrlinger	Hirrlinger	NNP
cord-002209-xs6qigg4	162	22	and	and	CC
cord-002209-xs6qigg4	162	23	Nave	Nave	NNP
cord-002209-xs6qigg4	162	24	,	,	,
cord-002209-xs6qigg4	162	25	2014	2014	CD
cord-002209-xs6qigg4	162	26	)	)	-RRB-
cord-002209-xs6qigg4	162	27	.	.	.
cord-002209-xs6qigg4	163	1	The	the	DT
cord-002209-xs6qigg4	163	2	importance	importance	NN
cord-002209-xs6qigg4	163	3	of	of	IN
cord-002209-xs6qigg4	163	4	lactate	lactate	NN
cord-002209-xs6qigg4	163	5	during	during	IN
cord-002209-xs6qigg4	163	6	demyelination	demyelination	NN
cord-002209-xs6qigg4	163	7	is	be	VBZ
cord-002209-xs6qigg4	163	8	only	only	RB
cord-002209-xs6qigg4	163	9	just	just	RB
cord-002209-xs6qigg4	163	10	emerging	emerge	VBG
cord-002209-xs6qigg4	163	11	.	.	.
cord-002209-xs6qigg4	164	1	Whether	whether	IN
cord-002209-xs6qigg4	164	2	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	164	3	maintain	maintain	VBP
cord-002209-xs6qigg4	164	4	the	the	DT
cord-002209-xs6qigg4	164	5	energy	energy	NN
cord-002209-xs6qigg4	164	6	levels	level	NNS
cord-002209-xs6qigg4	164	7	of	of	IN
cord-002209-xs6qigg4	164	8	only	only	JJ
cord-002209-xs6qigg4	164	9	axons	axon	NNS
cord-002209-xs6qigg4	164	10	as	as	RB
cord-002209-xs6qigg4	164	11	previously	previously	RB
cord-002209-xs6qigg4	164	12	thought	think	VBN
cord-002209-xs6qigg4	164	13	,	,	,
cord-002209-xs6qigg4	164	14	or	or	CC
cord-002209-xs6qigg4	164	15	if	if	IN
cord-002209-xs6qigg4	164	16	this	this	DT
cord-002209-xs6qigg4	164	17	extends	extend	VBZ
cord-002209-xs6qigg4	164	18	to	to	IN
cord-002209-xs6qigg4	164	19	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	164	20	as	as	RB
cord-002209-xs6qigg4	164	21	well	well	RB
cord-002209-xs6qigg4	164	22	,	,	,
cord-002209-xs6qigg4	164	23	is	be	VBZ
cord-002209-xs6qigg4	164	24	an	an	DT
cord-002209-xs6qigg4	164	25	interesting	interesting	JJ
cord-002209-xs6qigg4	164	26	concept	concept	NN
cord-002209-xs6qigg4	164	27	.	.	.
cord-002209-xs6qigg4	165	1	Oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	165	2	are	be	VBP
cord-002209-xs6qigg4	165	3	known	know	VBN
cord-002209-xs6qigg4	165	4	to	to	TO
cord-002209-xs6qigg4	165	5	consume	consume	VB
cord-002209-xs6qigg4	165	6	lactate	lactate	NN
cord-002209-xs6qigg4	165	7	at	at	IN
cord-002209-xs6qigg4	165	8	higher	high	JJR
cord-002209-xs6qigg4	165	9	levels	level	NNS
cord-002209-xs6qigg4	165	10	than	than	IN
cord-002209-xs6qigg4	165	11	other	other	JJ
cord-002209-xs6qigg4	165	12	CNS	CNS	NNP
cord-002209-xs6qigg4	165	13	cells	cell	NNS
cord-002209-xs6qigg4	165	14	,	,	,
cord-002209-xs6qigg4	165	15	therefore	therefore	RB
cord-002209-xs6qigg4	165	16	making	make	VBG
cord-002209-xs6qigg4	165	17	them	-PRON-	PRP
cord-002209-xs6qigg4	165	18	an	an	DT
cord-002209-xs6qigg4	165	19	important	important	JJ
cord-002209-xs6qigg4	165	20	user	user	NN
cord-002209-xs6qigg4	165	21	of	of	IN
cord-002209-xs6qigg4	165	22	any	any	DT
cord-002209-xs6qigg4	165	23	lactate	lactate	NN
cord-002209-xs6qigg4	165	24	production	production	NN
cord-002209-xs6qigg4	165	25	.	.	.
cord-002209-xs6qigg4	166	1	Furthermore	furthermore	RB
cord-002209-xs6qigg4	166	2	,	,	,
cord-002209-xs6qigg4	166	3	promotion	promotion	NN
cord-002209-xs6qigg4	166	4	of	of	IN
cord-002209-xs6qigg4	166	5	myelination	myelination	NN
cord-002209-xs6qigg4	166	6	via	via	IN
cord-002209-xs6qigg4	166	7	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	166	8	has	have	VBZ
cord-002209-xs6qigg4	166	9	been	be	VBN
cord-002209-xs6qigg4	166	10	shown	show	VBN
cord-002209-xs6qigg4	166	11	when	when	WRB
cord-002209-xs6qigg4	166	12	endogenous	endogenous	JJ
cord-002209-xs6qigg4	166	13	lactate	lactate	NN
cord-002209-xs6qigg4	166	14	is	be	VBZ
cord-002209-xs6qigg4	166	15	applied	apply	VBN
cord-002209-xs6qigg4	166	16	(	(	-LRB-
cord-002209-xs6qigg4	166	17	Rinholm	Rinholm	NNP
cord-002209-xs6qigg4	166	18	and	and	CC
cord-002209-xs6qigg4	166	19	Bergersen	Bergersen	NNP
cord-002209-xs6qigg4	166	20	,	,	,
cord-002209-xs6qigg4	166	21	2012	2012	CD
cord-002209-xs6qigg4	166	22	)	)	-RRB-
cord-002209-xs6qigg4	167	1	therefore	therefore	RB
cord-002209-xs6qigg4	167	2	at	at	IN
cord-002209-xs6qigg4	167	3	least	least	JJS
cord-002209-xs6qigg4	167	4	some	some	DT
cord-002209-xs6qigg4	167	5	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	167	6	lactate	lactate	NN
cord-002209-xs6qigg4	167	7	production	production	NN
cord-002209-xs6qigg4	167	8	may	may	MD
cord-002209-xs6qigg4	167	9	be	be	VB
cord-002209-xs6qigg4	167	10	targeted	target	VBN
cord-002209-xs6qigg4	167	11	to	to	IN
cord-002209-xs6qigg4	167	12	myelinating	myelinate	VBG
cord-002209-xs6qigg4	167	13	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	167	14	(	(	-LRB-
cord-002209-xs6qigg4	167	15	Sánchez	Sánchez	NNP
cord-002209-xs6qigg4	167	16	-	-	HYPH
cord-002209-xs6qigg4	167	17	Abarca	Abarca	NNP
cord-002209-xs6qigg4	167	18	et	et	NNP
cord-002209-xs6qigg4	167	19	al	al	NNP
cord-002209-xs6qigg4	167	20	.	.	.
cord-002209-xs6qigg4	168	1	,	,	,
cord-002209-xs6qigg4	168	2	2001	2001	CD
cord-002209-xs6qigg4	168	3	;	;	:
cord-002209-xs6qigg4	168	4	Rinholm	Rinholm	NNP
cord-002209-xs6qigg4	168	5	et	et	NNP
cord-002209-xs6qigg4	168	6	al	al	NNP
cord-002209-xs6qigg4	168	7	.	.	NNP
cord-002209-xs6qigg4	168	8	,	,	,
cord-002209-xs6qigg4	168	9	2011	2011	CD
cord-002209-xs6qigg4	168	10	)	)	-RRB-
cord-002209-xs6qigg4	168	11	.	.	.
cord-002209-xs6qigg4	169	1	However	however	RB
cord-002209-xs6qigg4	169	2	,	,	,
cord-002209-xs6qigg4	169	3	energy	energy	NN
cord-002209-xs6qigg4	169	4	regulation	regulation	NN
cord-002209-xs6qigg4	169	5	in	in	IN
cord-002209-xs6qigg4	169	6	the	the	DT
cord-002209-xs6qigg4	169	7	CNS	CNS	NNP
cord-002209-xs6qigg4	169	8	is	be	VBZ
cord-002209-xs6qigg4	169	9	more	more	RBR
cord-002209-xs6qigg4	169	10	complex	complex	JJ
cord-002209-xs6qigg4	169	11	as	as	IN
cord-002209-xs6qigg4	169	12	recent	recent	JJ
cord-002209-xs6qigg4	169	13	evidence	evidence	NN
cord-002209-xs6qigg4	169	14	has	have	VBZ
cord-002209-xs6qigg4	169	15	shown	show	VBN
cord-002209-xs6qigg4	169	16	that	that	IN
cord-002209-xs6qigg4	169	17	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	169	18	in	in	IN
cord-002209-xs6qigg4	169	19	turn	turn	NN
cord-002209-xs6qigg4	169	20	can	can	MD
cord-002209-xs6qigg4	169	21	transfer	transfer	VB
cord-002209-xs6qigg4	169	22	glycolysis	glycolysis	NN
cord-002209-xs6qigg4	169	23	products	product	NNS
cord-002209-xs6qigg4	169	24	such	such	JJ
cord-002209-xs6qigg4	169	25	as	as	IN
cord-002209-xs6qigg4	169	26	lactate	lactate	NN
cord-002209-xs6qigg4	169	27	to	to	IN
cord-002209-xs6qigg4	169	28	axons	axon	NNS
cord-002209-xs6qigg4	169	29	via	via	IN
cord-002209-xs6qigg4	169	30	monocarboxylic	monocarboxylic	JJ
cord-002209-xs6qigg4	169	31	acid	acid	NN
cord-002209-xs6qigg4	169	32	transporters	transporter	NNS
cord-002209-xs6qigg4	169	33	(	(	-LRB-
cord-002209-xs6qigg4	169	34	MCT1	MCT1	NNP
cord-002209-xs6qigg4	169	35	,	,	,
cord-002209-xs6qigg4	169	36	MCT2	MCT2	NNP
cord-002209-xs6qigg4	169	37	)	)	-RRB-
cord-002209-xs6qigg4	169	38	,	,	,
cord-002209-xs6qigg4	169	39	which	which	WDT
cord-002209-xs6qigg4	169	40	reside	reside	VBP
cord-002209-xs6qigg4	169	41	in	in	IN
cord-002209-xs6qigg4	169	42	internodal	internodal	JJ
cord-002209-xs6qigg4	169	43	myelin	myelin	NN
cord-002209-xs6qigg4	169	44	and	and	CC
cord-002209-xs6qigg4	169	45	the	the	DT
cord-002209-xs6qigg4	169	46	axonal	axonal	JJ
cord-002209-xs6qigg4	169	47	compartment	compartment	NN
cord-002209-xs6qigg4	169	48	(	(	-LRB-
cord-002209-xs6qigg4	169	49	Fünfschilling	Fünfschilling	NNP
cord-002209-xs6qigg4	169	50	et	et	FW
cord-002209-xs6qigg4	169	51	al	al	NNP
cord-002209-xs6qigg4	169	52	.	.	NNP
cord-002209-xs6qigg4	169	53	,	,	,
cord-002209-xs6qigg4	169	54	2012	2012	CD
cord-002209-xs6qigg4	169	55	)	)	-RRB-
cord-002209-xs6qigg4	169	56	.	.	.
cord-002209-xs6qigg4	170	1	Cholesterol	cholesterol	NN
cord-002209-xs6qigg4	170	2	is	be	VBZ
cord-002209-xs6qigg4	170	3	essential	essential	JJ
cord-002209-xs6qigg4	170	4	to	to	IN
cord-002209-xs6qigg4	170	5	every	every	DT
cord-002209-xs6qigg4	170	6	cell	cell	NN
cord-002209-xs6qigg4	170	7	in	in	IN
cord-002209-xs6qigg4	170	8	the	the	DT
cord-002209-xs6qigg4	170	9	body	body	NN
cord-002209-xs6qigg4	170	10	as	as	IN
cord-002209-xs6qigg4	170	11	it	-PRON-	PRP
cord-002209-xs6qigg4	170	12	is	be	VBZ
cord-002209-xs6qigg4	170	13	an	an	DT
cord-002209-xs6qigg4	170	14	important	important	JJ
cord-002209-xs6qigg4	170	15	component	component	NN
cord-002209-xs6qigg4	170	16	of	of	IN
cord-002209-xs6qigg4	170	17	cellular	cellular	JJ
cord-002209-xs6qigg4	170	18	membranes	membrane	NNS
cord-002209-xs6qigg4	170	19	.	.	.
cord-002209-xs6qigg4	171	1	In	in	IN
cord-002209-xs6qigg4	171	2	the	the	DT
cord-002209-xs6qigg4	171	3	CNS	CNS	NNP
cord-002209-xs6qigg4	171	4	it	-PRON-	PRP
cord-002209-xs6qigg4	171	5	is	be	VBZ
cord-002209-xs6qigg4	171	6	vital	vital	JJ
cord-002209-xs6qigg4	171	7	for	for	IN
cord-002209-xs6qigg4	171	8	normal	normal	JJ
cord-002209-xs6qigg4	171	9	brain	brain	NN
cord-002209-xs6qigg4	171	10	development	development	NN
cord-002209-xs6qigg4	171	11	,	,	,
cord-002209-xs6qigg4	171	12	is	be	VBZ
cord-002209-xs6qigg4	171	13	a	a	DT
cord-002209-xs6qigg4	171	14	precursor	precursor	NN
cord-002209-xs6qigg4	171	15	to	to	IN
cord-002209-xs6qigg4	171	16	many	many	JJ
cord-002209-xs6qigg4	171	17	signalling	signal	VBG
cord-002209-xs6qigg4	171	18	molecules	molecule	NNS
cord-002209-xs6qigg4	171	19	such	such	JJ
cord-002209-xs6qigg4	171	20	as	as	IN
cord-002209-xs6qigg4	171	21	steroid	steroid	NN
cord-002209-xs6qigg4	171	22	hormones	hormone	NNS
cord-002209-xs6qigg4	171	23	,	,	,
cord-002209-xs6qigg4	171	24	and	and	CC
cord-002209-xs6qigg4	171	25	importantly	importantly	RB
cord-002209-xs6qigg4	171	26	,	,	,
cord-002209-xs6qigg4	171	27	is	be	VBZ
cord-002209-xs6qigg4	171	28	a	a	DT
cord-002209-xs6qigg4	171	29	major	major	JJ
cord-002209-xs6qigg4	171	30	structural	structural	JJ
cord-002209-xs6qigg4	171	31	component	component	NN
cord-002209-xs6qigg4	171	32	of	of	IN
cord-002209-xs6qigg4	171	33	myelin	myelin	NN
cord-002209-xs6qigg4	171	34	sheaths	sheath	NNS
cord-002209-xs6qigg4	171	35	(	(	-LRB-
cord-002209-xs6qigg4	171	36	Siegel	Siegel	NNP
cord-002209-xs6qigg4	171	37	et	et	NNP
cord-002209-xs6qigg4	171	38	al	al	NNP
cord-002209-xs6qigg4	171	39	.	.	NNP
cord-002209-xs6qigg4	171	40	,	,	,
cord-002209-xs6qigg4	171	41	1999	1999	CD
cord-002209-xs6qigg4	171	42	)	)	-RRB-
cord-002209-xs6qigg4	171	43	.	.	.
cord-002209-xs6qigg4	172	1	The	the	DT
cord-002209-xs6qigg4	172	2	BBB	BBB	NNP
cord-002209-xs6qigg4	172	3	prevents	prevent	VBZ
cord-002209-xs6qigg4	172	4	the	the	DT
cord-002209-xs6qigg4	172	5	transport	transport	NN
cord-002209-xs6qigg4	172	6	of	of	IN
cord-002209-xs6qigg4	172	7	either	either	CC
cord-002209-xs6qigg4	172	8	hepatic	hepatic	JJ
cord-002209-xs6qigg4	172	9	or	or	CC
cord-002209-xs6qigg4	172	10	dietary	dietary	JJ
cord-002209-xs6qigg4	172	11	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	172	12	,	,	,
cord-002209-xs6qigg4	172	13	meaning	mean	VBG
cord-002209-xs6qigg4	172	14	that	that	IN
cord-002209-xs6qigg4	172	15	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	172	16	must	must	MD
cord-002209-xs6qigg4	172	17	be	be	VB
cord-002209-xs6qigg4	172	18	derived	derive	VBN
cord-002209-xs6qigg4	172	19	by	by	IN
cord-002209-xs6qigg4	172	20	de	de	FW
cord-002209-xs6qigg4	172	21	novo	novo	NNP
cord-002209-xs6qigg4	172	22	synthesis	synthesis	NN
cord-002209-xs6qigg4	172	23	within	within	IN
cord-002209-xs6qigg4	172	24	the	the	DT
cord-002209-xs6qigg4	172	25	CNS	CNS	NNP
cord-002209-xs6qigg4	172	26	(	(	-LRB-
cord-002209-xs6qigg4	172	27	Orth	Orth	NNP
cord-002209-xs6qigg4	172	28	and	and	CC
cord-002209-xs6qigg4	172	29	Bellosta	Bellosta	NNP
cord-002209-xs6qigg4	172	30	,	,	,
cord-002209-xs6qigg4	172	31	2012	2012	CD
cord-002209-xs6qigg4	172	32	)	)	-RRB-
cord-002209-xs6qigg4	172	33	.	.	.
cord-002209-xs6qigg4	173	1	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	173	2	are	be	VBP
cord-002209-xs6qigg4	173	3	proposed	propose	VBN
cord-002209-xs6qigg4	173	4	to	to	TO
cord-002209-xs6qigg4	173	5	be	be	VB
cord-002209-xs6qigg4	173	6	one	one	CD
cord-002209-xs6qigg4	173	7	of	of	IN
cord-002209-xs6qigg4	173	8	the	the	DT
cord-002209-xs6qigg4	173	9	primary	primary	JJ
cord-002209-xs6qigg4	173	10	cellular	cellular	JJ
cord-002209-xs6qigg4	173	11	sources	source	NNS
cord-002209-xs6qigg4	173	12	of	of	IN
cord-002209-xs6qigg4	173	13	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	173	14	(	(	-LRB-
cord-002209-xs6qigg4	173	15	Pfrieger	Pfrieger	NNP
cord-002209-xs6qigg4	173	16	and	and	CC
cord-002209-xs6qigg4	173	17	Ungerer	Ungerer	NNP
cord-002209-xs6qigg4	173	18	,	,	,
cord-002209-xs6qigg4	173	19	2011	2011	CD
cord-002209-xs6qigg4	173	20	)	)	-RRB-
cord-002209-xs6qigg4	173	21	and	and	CC
cord-002209-xs6qigg4	173	22	mediate	mediate	VB
cord-002209-xs6qigg4	173	23	its	-PRON-	PRP$
cord-002209-xs6qigg4	173	24	secretion	secretion	NN
cord-002209-xs6qigg4	173	25	by	by	IN
cord-002209-xs6qigg4	173	26	their	-PRON-	PRP$
cord-002209-xs6qigg4	173	27	expression	expression	NN
cord-002209-xs6qigg4	173	28	of	of	IN
cord-002209-xs6qigg4	173	29	several	several	JJ
cord-002209-xs6qigg4	173	30	apolipoproteins	apolipoprotein	NNS
cord-002209-xs6qigg4	173	31	,	,	,
cord-002209-xs6qigg4	173	32	molecules	molecule	NNS
cord-002209-xs6qigg4	173	33	that	that	WDT
cord-002209-xs6qigg4	173	34	bind	bind	VBP
cord-002209-xs6qigg4	173	35	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	173	36	(	(	-LRB-
cord-002209-xs6qigg4	173	37	Boyles	Boyles	NNP
cord-002209-xs6qigg4	173	38	et	et	NNP
cord-002209-xs6qigg4	173	39	al	al	NNP
cord-002209-xs6qigg4	173	40	.	.	NNP
cord-002209-xs6qigg4	173	41	,	,	,
cord-002209-xs6qigg4	173	42	1985	1985	CD
cord-002209-xs6qigg4	173	43	;	;	:
cord-002209-xs6qigg4	173	44	Lin	Lin	NNP
cord-002209-xs6qigg4	173	45	et	et	NNP
cord-002209-xs6qigg4	173	46	al	al	NNP
cord-002209-xs6qigg4	173	47	.	.	NNP
cord-002209-xs6qigg4	173	48	,	,	,
cord-002209-xs6qigg4	173	49	1986	1986	CD
cord-002209-xs6qigg4	173	50	;	;	:
cord-002209-xs6qigg4	173	51	Xu	Xu	NNP
cord-002209-xs6qigg4	173	52	et	et	NNP
cord-002209-xs6qigg4	173	53	al	al	NNP
cord-002209-xs6qigg4	173	54	.	.	NNP
cord-002209-xs6qigg4	173	55	,	,	,
cord-002209-xs6qigg4	173	56	2006	2006	CD
cord-002209-xs6qigg4	173	57	;	;	:
cord-002209-xs6qigg4	173	58	Kurumada	Kurumada	NNP
cord-002209-xs6qigg4	173	59	et	et	NNP
cord-002209-xs6qigg4	173	60	al	al	NNP
cord-002209-xs6qigg4	173	61	.	.	NNP
cord-002209-xs6qigg4	173	62	,	,	,
cord-002209-xs6qigg4	173	63	2007	2007	CD
cord-002209-xs6qigg4	173	64	)	)	-RRB-
cord-002209-xs6qigg4	173	65	.	.	.
cord-002209-xs6qigg4	174	1	There	there	EX
cord-002209-xs6qigg4	174	2	is	be	VBZ
cord-002209-xs6qigg4	174	3	sufficient	sufficient	JJ
cord-002209-xs6qigg4	174	4	evidence	evidence	NN
cord-002209-xs6qigg4	174	5	to	to	TO
cord-002209-xs6qigg4	174	6	suggest	suggest	VB
cord-002209-xs6qigg4	174	7	that	that	IN
cord-002209-xs6qigg4	174	8	there	there	EX
cord-002209-xs6qigg4	174	9	is	be	VBZ
cord-002209-xs6qigg4	174	10	horizontal	horizontal	JJ
cord-002209-xs6qigg4	174	11	transfer	transfer	NN
cord-002209-xs6qigg4	174	12	of	of	IN
cord-002209-xs6qigg4	174	13	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	174	14	(	(	-LRB-
cord-002209-xs6qigg4	174	15	Boyles	Boyles	NNP
cord-002209-xs6qigg4	174	16	et	et	NNP
cord-002209-xs6qigg4	174	17	al	al	NNP
cord-002209-xs6qigg4	174	18	.	.	NNP
cord-002209-xs6qigg4	174	19	,	,	,
cord-002209-xs6qigg4	174	20	1985	1985	CD
cord-002209-xs6qigg4	174	21	;	;	:
cord-002209-xs6qigg4	175	1	Lin	Lin	NNP
cord-002209-xs6qigg4	175	2	et	et	NNP
cord-002209-xs6qigg4	175	3	al	al	NNP
cord-002209-xs6qigg4	175	4	.	.	NNP
cord-002209-xs6qigg4	175	5	,	,	,
cord-002209-xs6qigg4	175	6	1986	1986	CD
cord-002209-xs6qigg4	175	7	;	;	:
cord-002209-xs6qigg4	175	8	Xu	Xu	NNP
cord-002209-xs6qigg4	175	9	et	et	NNP
cord-002209-xs6qigg4	175	10	al	al	NNP
cord-002209-xs6qigg4	175	11	.	.	NNP
cord-002209-xs6qigg4	175	12	,	,	,
cord-002209-xs6qigg4	175	13	2006	2006	CD
cord-002209-xs6qigg4	175	14	;	;	:
cord-002209-xs6qigg4	175	15	Kurumada	Kurumada	NNP
cord-002209-xs6qigg4	175	16	et	et	NNP
cord-002209-xs6qigg4	175	17	al	al	NNP
cord-002209-xs6qigg4	175	18	.	.	NNP
cord-002209-xs6qigg4	175	19	,	,	,
cord-002209-xs6qigg4	175	20	2007	2007	CD
cord-002209-xs6qigg4	175	21	)	)	-RRB-
cord-002209-xs6qigg4	175	22	with	with	IN
cord-002209-xs6qigg4	175	23	both	both	DT
cord-002209-xs6qigg4	175	24	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	175	25	and	and	CC
cord-002209-xs6qigg4	175	26	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	175	27	producing	produce	VBG
cord-002209-xs6qigg4	175	28	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	175	29	to	to	TO
cord-002209-xs6qigg4	175	30	maintain	maintain	VB
cord-002209-xs6qigg4	175	31	myelin	myelin	JJ
cord-002209-xs6qigg4	175	32	sheath	sheath	NN
cord-002209-xs6qigg4	175	33	formation	formation	NN
cord-002209-xs6qigg4	175	34	and	and	CC
cord-002209-xs6qigg4	175	35	neurons	neuron	NNS
cord-002209-xs6qigg4	175	36	.	.	.
cord-002209-xs6qigg4	176	1	This	this	DT
cord-002209-xs6qigg4	176	2	transfer	transfer	NN
cord-002209-xs6qigg4	176	3	between	between	IN
cord-002209-xs6qigg4	176	4	cells	cell	NNS
cord-002209-xs6qigg4	176	5	is	be	VBZ
cord-002209-xs6qigg4	176	6	critically	critically	RB
cord-002209-xs6qigg4	176	7	relevant	relevant	JJ
cord-002209-xs6qigg4	176	8	to	to	IN
cord-002209-xs6qigg4	176	9	neurodegenerative	neurodegenerative	JJ
cord-002209-xs6qigg4	176	10	diseases	disease	NNS
cord-002209-xs6qigg4	176	11	,	,	,
cord-002209-xs6qigg4	176	12	since	since	IN
cord-002209-xs6qigg4	176	13	the	the	DT
cord-002209-xs6qigg4	176	14	availability	availability	NN
cord-002209-xs6qigg4	176	15	of	of	IN
cord-002209-xs6qigg4	176	16	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	176	17	is	be	VBZ
cord-002209-xs6qigg4	176	18	thought	think	VBN
cord-002209-xs6qigg4	176	19	to	to	TO
cord-002209-xs6qigg4	176	20	be	be	VB
cord-002209-xs6qigg4	176	21	an	an	DT
cord-002209-xs6qigg4	176	22	essential	essential	JJ
cord-002209-xs6qigg4	176	23	rate	rate	NN
cord-002209-xs6qigg4	176	24	limiting	limit	VBG
cord-002209-xs6qigg4	176	25	factor	factor	NN
cord-002209-xs6qigg4	176	26	to	to	IN
cord-002209-xs6qigg4	176	27	myelin	myelin	NN
cord-002209-xs6qigg4	176	28	production	production	NN
cord-002209-xs6qigg4	177	1	(	(	-LRB-
cord-002209-xs6qigg4	177	2	May	May	MD
cord-002209-xs6qigg4	177	3	et	et	NNP
cord-002209-xs6qigg4	177	4	al	al	NNP
cord-002209-xs6qigg4	177	5	.	.	NNP
cord-002209-xs6qigg4	177	6	,	,	,
cord-002209-xs6qigg4	177	7	2004	2004	CD
cord-002209-xs6qigg4	177	8	;	;	:
cord-002209-xs6qigg4	177	9	Liu	Liu	NNP
cord-002209-xs6qigg4	177	10	et	et	NNP
cord-002209-xs6qigg4	177	11	al	al	NNP
cord-002209-xs6qigg4	177	12	.	.	NNP
cord-002209-xs6qigg4	177	13	,	,	,
cord-002209-xs6qigg4	177	14	2010	2010	CD
cord-002209-xs6qigg4	177	15	)	)	-RRB-
cord-002209-xs6qigg4	177	16	.	.	.
cord-002209-xs6qigg4	178	1	Therefore	therefore	RB
cord-002209-xs6qigg4	178	2	,	,	,
cord-002209-xs6qigg4	178	3	in	in	IN
cord-002209-xs6qigg4	178	4	addition	addition	NN
cord-002209-xs6qigg4	178	5	to	to	IN
cord-002209-xs6qigg4	178	6	their	-PRON-	PRP$
cord-002209-xs6qigg4	178	7	roles	role	NNS
cord-002209-xs6qigg4	178	8	in	in	IN
cord-002209-xs6qigg4	178	9	providing	provide	VBG
cord-002209-xs6qigg4	178	10	energy	energy	NN
cord-002209-xs6qigg4	178	11	to	to	IN
cord-002209-xs6qigg4	178	12	neurons	neuron	NNS
cord-002209-xs6qigg4	178	13	,	,	,
cord-002209-xs6qigg4	178	14	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	178	15	also	also	RB
cord-002209-xs6qigg4	178	16	emerge	emerge	VBP
cord-002209-xs6qigg4	178	17	as	as	IN
cord-002209-xs6qigg4	178	18	important	important	JJ
cord-002209-xs6qigg4	178	19	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	178	20	-	-	HYPH
cord-002209-xs6qigg4	178	21	suppliers	supplier	NNS
cord-002209-xs6qigg4	178	22	in	in	IN
cord-002209-xs6qigg4	178	23	the	the	DT
cord-002209-xs6qigg4	178	24	CNS	CNS	NNP
cord-002209-xs6qigg4	178	25	,	,	,
cord-002209-xs6qigg4	178	26	which	which	WDT
cord-002209-xs6qigg4	178	27	is	be	VBZ
cord-002209-xs6qigg4	178	28	vital	vital	JJ
cord-002209-xs6qigg4	178	29	for	for	IN
cord-002209-xs6qigg4	178	30	myelination	myelination	NN
cord-002209-xs6qigg4	178	31	.	.	.
cord-002209-xs6qigg4	179	1	A	a	DT
cord-002209-xs6qigg4	179	2	further	further	JJ
cord-002209-xs6qigg4	179	3	function	function	NN
cord-002209-xs6qigg4	179	4	of	of	IN
cord-002209-xs6qigg4	179	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	179	6	is	be	VBZ
cord-002209-xs6qigg4	179	7	the	the	DT
cord-002209-xs6qigg4	179	8	removal	removal	NN
cord-002209-xs6qigg4	179	9	of	of	IN
cord-002209-xs6qigg4	179	10	excitotoxic	excitotoxic	JJ
cord-002209-xs6qigg4	179	11	molecules	molecule	NNS
cord-002209-xs6qigg4	179	12	from	from	IN
cord-002209-xs6qigg4	179	13	the	the	DT
cord-002209-xs6qigg4	179	14	extracellular	extracellular	JJ
cord-002209-xs6qigg4	179	15	space	space	NN
cord-002209-xs6qigg4	179	16	,	,	,
cord-002209-xs6qigg4	179	17	thus	thus	RB
cord-002209-xs6qigg4	179	18	supporting	support	VBG
cord-002209-xs6qigg4	179	19	neuronal	neuronal	JJ
cord-002209-xs6qigg4	179	20	survival	survival	NN
cord-002209-xs6qigg4	179	21	.	.	.
cord-002209-xs6qigg4	180	1	They	-PRON-	PRP
cord-002209-xs6qigg4	180	2	can	can	MD
cord-002209-xs6qigg4	180	3	actively	actively	RB
cord-002209-xs6qigg4	180	4	remove	remove	VB
cord-002209-xs6qigg4	180	5	excitotoxic	excitotoxic	JJ
cord-002209-xs6qigg4	180	6	glutamate	glutamate	NN
cord-002209-xs6qigg4	180	7	and	and	CC
cord-002209-xs6qigg4	180	8	convert	convert	VB
cord-002209-xs6qigg4	180	9	it	-PRON-	PRP
cord-002209-xs6qigg4	180	10	to	to	IN
cord-002209-xs6qigg4	180	11	glutamine	glutamine	NN
cord-002209-xs6qigg4	180	12	by	by	IN
cord-002209-xs6qigg4	180	13	increasing	increase	VBG
cord-002209-xs6qigg4	180	14	their	-PRON-	PRP$
cord-002209-xs6qigg4	180	15	levels	level	NNS
cord-002209-xs6qigg4	180	16	of	of	IN
cord-002209-xs6qigg4	180	17	glutamate	glutamate	NN
cord-002209-xs6qigg4	180	18	transporters	transporter	NNS
cord-002209-xs6qigg4	180	19	and	and	CC
cord-002209-xs6qigg4	180	20	glutamine	glutamine	NN
cord-002209-xs6qigg4	180	21	synthetase	synthetase	NN
cord-002209-xs6qigg4	180	22	(	(	-LRB-
cord-002209-xs6qigg4	180	23	Faden	Faden	NNP
cord-002209-xs6qigg4	180	24	et	et	NNP
cord-002209-xs6qigg4	180	25	al	al	NNP
cord-002209-xs6qigg4	180	26	.	.	NNP
cord-002209-xs6qigg4	180	27	,	,	,
cord-002209-xs6qigg4	180	28	1989	1989	CD
cord-002209-xs6qigg4	180	29	;	;	:
cord-002209-xs6qigg4	181	1	Eng	Eng	NNP
cord-002209-xs6qigg4	181	2	et	et	NNP
cord-002209-xs6qigg4	181	3	al	al	NNP
cord-002209-xs6qigg4	181	4	.	.	.
cord-002209-xs6qigg4	182	1	,	,	,
cord-002209-xs6qigg4	182	2	1997	1997	CD
cord-002209-xs6qigg4	182	3	;	;	:
cord-002209-xs6qigg4	182	4	Krum	Krum	NNP
cord-002209-xs6qigg4	182	5	et	et	NNP
cord-002209-xs6qigg4	182	6	al	al	NNP
cord-002209-xs6qigg4	182	7	.	.	NNP
cord-002209-xs6qigg4	182	8	,	,	,
cord-002209-xs6qigg4	182	9	2002	2002	CD
cord-002209-xs6qigg4	182	10	)	)	-RRB-
cord-002209-xs6qigg4	182	11	,	,	,
cord-002209-xs6qigg4	182	12	thereby	thereby	RB
cord-002209-xs6qigg4	182	13	preventing	prevent	VBG
cord-002209-xs6qigg4	182	14	neuronal	neuronal	JJ
cord-002209-xs6qigg4	182	15	cell	cell	NN
cord-002209-xs6qigg4	182	16	death	death	NN
cord-002209-xs6qigg4	182	17	during	during	IN
cord-002209-xs6qigg4	182	18	brain	brain	NN
cord-002209-xs6qigg4	182	19	pathology	pathology	NN
cord-002209-xs6qigg4	182	20	.	.	.
cord-002209-xs6qigg4	183	1	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	183	2	can	can	MD
cord-002209-xs6qigg4	183	3	also	also	RB
cord-002209-xs6qigg4	183	4	release	release	VB
cord-002209-xs6qigg4	183	5	gliotransmitters	gliotransmitter	NNS
cord-002209-xs6qigg4	183	6	such	such	JJ
cord-002209-xs6qigg4	183	7	as	as	IN
cord-002209-xs6qigg4	183	8	glutamate	glutamate	NN
cord-002209-xs6qigg4	183	9	,	,	,
cord-002209-xs6qigg4	183	10	purine	purine	NN
cord-002209-xs6qigg4	183	11	,	,	,
cord-002209-xs6qigg4	183	12	GABA	GABA	NNP
cord-002209-xs6qigg4	183	13	and	and	CC
cord-002209-xs6qigg4	183	14	D	d	NN
cord-002209-xs6qigg4	183	15	-	-	HYPH
cord-002209-xs6qigg4	183	16	serine	serine	NN
cord-002209-xs6qigg4	183	17	into	into	IN
cord-002209-xs6qigg4	183	18	the	the	DT
cord-002209-xs6qigg4	183	19	synaptic	synaptic	JJ
cord-002209-xs6qigg4	183	20	cleft	cleft	NN
cord-002209-xs6qigg4	183	21	upon	upon	IN
cord-002209-xs6qigg4	183	22	excitation	excitation	NN
cord-002209-xs6qigg4	183	23	by	by	IN
cord-002209-xs6qigg4	183	24	changes	change	NNS
cord-002209-xs6qigg4	183	25	in	in	IN
cord-002209-xs6qigg4	183	26	neuronal	neuronal	JJ
cord-002209-xs6qigg4	183	27	synaptic	synaptic	JJ
cord-002209-xs6qigg4	183	28	activity	activity	NN
cord-002209-xs6qigg4	183	29	and	and	CC
cord-002209-xs6qigg4	183	30	can	can	MD
cord-002209-xs6qigg4	183	31	thereby	thereby	RB
cord-002209-xs6qigg4	183	32	regulate	regulate	VB
cord-002209-xs6qigg4	183	33	neuronal	neuronal	JJ
cord-002209-xs6qigg4	183	34	excitability	excitability	NN
cord-002209-xs6qigg4	183	35	(	(	-LRB-
cord-002209-xs6qigg4	184	1	Parpura	Parpura	NNP
cord-002209-xs6qigg4	184	2	et	et	NNP
cord-002209-xs6qigg4	184	3	al	al	NNP
cord-002209-xs6qigg4	184	4	.	.	.
cord-002209-xs6qigg4	185	1	,	,	,
cord-002209-xs6qigg4	185	2	1994	1994	CD
cord-002209-xs6qigg4	185	3	;	;	:
cord-002209-xs6qigg4	185	4	Bezzi	Bezzi	NNP
cord-002209-xs6qigg4	185	5	et	et	NNP
cord-002209-xs6qigg4	185	6	al	al	NNP
cord-002209-xs6qigg4	185	7	.	.	NNP
cord-002209-xs6qigg4	185	8	,	,	,
cord-002209-xs6qigg4	185	9	1998	1998	CD
cord-002209-xs6qigg4	186	1	;	;	:
cord-002209-xs6qigg4	186	2	Mothet	Mothet	NNP
cord-002209-xs6qigg4	186	3	et	et	NNP
cord-002209-xs6qigg4	186	4	al	al	NNP
cord-002209-xs6qigg4	186	5	.	.	NNP
cord-002209-xs6qigg4	186	6	,	,	,
cord-002209-xs6qigg4	186	7	2000	2000	CD
cord-002209-xs6qigg4	186	8	;	;	:
cord-002209-xs6qigg4	186	9	Coco	Coco	NNP
cord-002209-xs6qigg4	186	10	et	et	NNP
cord-002209-xs6qigg4	186	11	al	al	NNP
cord-002209-xs6qigg4	186	12	.	.	NNP
cord-002209-xs6qigg4	186	13	,	,	,
cord-002209-xs6qigg4	186	14	2003	2003	CD
cord-002209-xs6qigg4	187	1	;	;	:
cord-002209-xs6qigg4	187	2	Halassa	Halassa	NNP
cord-002209-xs6qigg4	187	3	et	et	NNP
cord-002209-xs6qigg4	187	4	al	al	NNP
cord-002209-xs6qigg4	187	5	.	.	NNP
cord-002209-xs6qigg4	187	6	,	,	,
cord-002209-xs6qigg4	187	7	2007	2007	CD
cord-002209-xs6qigg4	187	8	)	)	-RRB-
cord-002209-xs6qigg4	187	9	.	.	.
cord-002209-xs6qigg4	188	1	Neurotransmitter	neurotransmitter	NN
cord-002209-xs6qigg4	188	2	released	release	VBN
cord-002209-xs6qigg4	188	3	from	from	IN
cord-002209-xs6qigg4	188	4	the	the	DT
cord-002209-xs6qigg4	188	5	neuronal	neuronal	JJ
cord-002209-xs6qigg4	188	6	synapse	synapse	NN
cord-002209-xs6qigg4	188	7	can	can	MD
cord-002209-xs6qigg4	188	8	reach	reach	VB
cord-002209-xs6qigg4	188	9	adjacent	adjacent	JJ
cord-002209-xs6qigg4	188	10	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	188	11	,	,	,
cord-002209-xs6qigg4	188	12	stimulating	stimulate	VBG
cord-002209-xs6qigg4	188	13	increases	increase	NNS
cord-002209-xs6qigg4	188	14	in	in	IN
cord-002209-xs6qigg4	188	15	intracellular	intracellular	JJ
cord-002209-xs6qigg4	188	16	Ca	Ca	NNP
cord-002209-xs6qigg4	188	17	2	2	CD
cord-002209-xs6qigg4	188	18	+	+	SYM
cord-002209-xs6qigg4	188	19	concentrations	concentration	NNS
cord-002209-xs6qigg4	188	20	,	,	,
cord-002209-xs6qigg4	188	21	which	which	WDT
cord-002209-xs6qigg4	188	22	then	then	RB
cord-002209-xs6qigg4	188	23	leads	lead	VBZ
cord-002209-xs6qigg4	188	24	to	to	IN
cord-002209-xs6qigg4	188	25	the	the	DT
cord-002209-xs6qigg4	188	26	secretion	secretion	NN
cord-002209-xs6qigg4	188	27	of	of	IN
cord-002209-xs6qigg4	188	28	gliotransmitters	gliotransmitter	NNS
cord-002209-xs6qigg4	188	29	(	(	-LRB-
cord-002209-xs6qigg4	188	30	Porter	Porter	NNP
cord-002209-xs6qigg4	188	31	and	and	CC
cord-002209-xs6qigg4	188	32	McCarthy	McCarthy	NNP
cord-002209-xs6qigg4	188	33	,	,	,
cord-002209-xs6qigg4	188	34	1997	1997	CD
cord-002209-xs6qigg4	188	35	)	)	-RRB-
cord-002209-xs6qigg4	188	36	.	.	.
cord-002209-xs6qigg4	189	1	These	these	DT
cord-002209-xs6qigg4	189	2	regulatory	regulatory	JJ
cord-002209-xs6qigg4	189	3	molecules	molecule	NNS
cord-002209-xs6qigg4	189	4	then	then	RB
cord-002209-xs6qigg4	189	5	can	can	MD
cord-002209-xs6qigg4	189	6	feedback	feedback	VB
cord-002209-xs6qigg4	189	7	to	to	IN
cord-002209-xs6qigg4	189	8	presynaptic	presynaptic	JJ
cord-002209-xs6qigg4	189	9	nerve	nerve	NN
cord-002209-xs6qigg4	189	10	terminals	terminal	NNS
cord-002209-xs6qigg4	189	11	to	to	TO
cord-002209-xs6qigg4	189	12	modulate	modulate	VB
cord-002209-xs6qigg4	189	13	synaptic	synaptic	JJ
cord-002209-xs6qigg4	189	14	neurotransmission	neurotransmission	NN
cord-002209-xs6qigg4	189	15	(	(	-LRB-
cord-002209-xs6qigg4	189	16	Araque	Araque	NNP
cord-002209-xs6qigg4	189	17	et	et	FW
cord-002209-xs6qigg4	189	18	al	al	NNP
cord-002209-xs6qigg4	189	19	.	.	NNP
cord-002209-xs6qigg4	189	20	,	,	,
cord-002209-xs6qigg4	189	21	1998	1998	CD
cord-002209-xs6qigg4	189	22	)	)	-RRB-
cord-002209-xs6qigg4	189	23	.	.	.
cord-002209-xs6qigg4	190	1	These	these	DT
cord-002209-xs6qigg4	190	2	observations	observation	NNS
cord-002209-xs6qigg4	190	3	have	have	VBP
cord-002209-xs6qigg4	190	4	even	even	RB
cord-002209-xs6qigg4	190	5	given	give	VBN
cord-002209-xs6qigg4	190	6	rise	rise	NN
cord-002209-xs6qigg4	190	7	to	to	IN
cord-002209-xs6qigg4	190	8	the	the	DT
cord-002209-xs6qigg4	190	9	currently	currently	RB
cord-002209-xs6qigg4	190	10	accepted	accept	VBN
cord-002209-xs6qigg4	190	11	'	'	''
cord-002209-xs6qigg4	190	12	tripartite	tripartite	JJ
cord-002209-xs6qigg4	190	13	synapse	synapse	NN
cord-002209-xs6qigg4	190	14	'	'	''
cord-002209-xs6qigg4	190	15	hypothesis	hypothesis	NN
cord-002209-xs6qigg4	190	16	,	,	,
cord-002209-xs6qigg4	190	17	where	where	WRB
cord-002209-xs6qigg4	190	18	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	190	19	form	form	VBP
cord-002209-xs6qigg4	190	20	an	an	DT
cord-002209-xs6qigg4	190	21	active	active	JJ
cord-002209-xs6qigg4	190	22	,	,	,
cord-002209-xs6qigg4	190	23	integral	integral	JJ
cord-002209-xs6qigg4	190	24	regulatory	regulatory	JJ
cord-002209-xs6qigg4	190	25	component	component	NN
cord-002209-xs6qigg4	190	26	of	of	IN
cord-002209-xs6qigg4	190	27	the	the	DT
cord-002209-xs6qigg4	190	28	synapse	synapse	NN
cord-002209-xs6qigg4	191	1	(	(	-LRB-
cord-002209-xs6qigg4	191	2	Araque	Araque	NNP
cord-002209-xs6qigg4	191	3	et	et	NNP
cord-002209-xs6qigg4	191	4	al	al	NNP
cord-002209-xs6qigg4	191	5	.	.	.
cord-002209-xs6qigg4	192	1	,	,	,
cord-002209-xs6qigg4	192	2	1999	1999	CD
cord-002209-xs6qigg4	192	3	;	;	:
cord-002209-xs6qigg4	192	4	Halassa	Halassa	NNP
cord-002209-xs6qigg4	192	5	et	et	NNP
cord-002209-xs6qigg4	192	6	al	al	NNP
cord-002209-xs6qigg4	192	7	.	.	NNP
cord-002209-xs6qigg4	192	8	,	,	,
cord-002209-xs6qigg4	192	9	2007	2007	CD
cord-002209-xs6qigg4	192	10	)	)	-RRB-
cord-002209-xs6qigg4	192	11	.	.	.
cord-002209-xs6qigg4	193	1	Recently	recently	RB
cord-002209-xs6qigg4	193	2	,	,	,
cord-002209-xs6qigg4	193	3	electron	electron	NN
cord-002209-xs6qigg4	193	4	microscopy	microscopy	NN
cord-002209-xs6qigg4	193	5	has	have	VBZ
cord-002209-xs6qigg4	193	6	also	also	RB
cord-002209-xs6qigg4	193	7	shown	show	VBN
cord-002209-xs6qigg4	193	8	microglia	microglia	NNS
cord-002209-xs6qigg4	193	9	interacting	interact	VBG
cord-002209-xs6qigg4	193	10	with	with	IN
cord-002209-xs6qigg4	193	11	neuronal	neuronal	JJ
cord-002209-xs6qigg4	193	12	synapses	synapsis	NNS
cord-002209-xs6qigg4	193	13	(	(	-LRB-
cord-002209-xs6qigg4	193	14	Tremblay	Tremblay	NNP
cord-002209-xs6qigg4	193	15	et	et	NNP
cord-002209-xs6qigg4	193	16	al	al	NNP
cord-002209-xs6qigg4	193	17	.	.	NNP
cord-002209-xs6qigg4	193	18	,	,	,
cord-002209-xs6qigg4	193	19	2010	2010	CD
cord-002209-xs6qigg4	193	20	)	)	-RRB-
cord-002209-xs6qigg4	193	21	and	and	CC
cord-002209-xs6qigg4	193	22	playing	play	VBG
cord-002209-xs6qigg4	193	23	a	a	DT
cord-002209-xs6qigg4	193	24	role	role	NN
cord-002209-xs6qigg4	193	25	in	in	IN
cord-002209-xs6qigg4	193	26	synapse	synapse	NN
cord-002209-xs6qigg4	193	27	maturation	maturation	NN
cord-002209-xs6qigg4	193	28	,	,	,
cord-002209-xs6qigg4	193	29	synaptic	synaptic	JJ
cord-002209-xs6qigg4	193	30	remodelling	remodelling	NN
cord-002209-xs6qigg4	193	31	,	,	,
cord-002209-xs6qigg4	193	32	and	and	CC
cord-002209-xs6qigg4	193	33	synaptic	synaptic	JJ
cord-002209-xs6qigg4	193	34	activity	activity	NN
cord-002209-xs6qigg4	193	35	(	(	-LRB-
cord-002209-xs6qigg4	194	1	Ji	Ji	NNP
cord-002209-xs6qigg4	194	2	et	et	FW
cord-002209-xs6qigg4	194	3	al	al	NNP
cord-002209-xs6qigg4	194	4	.	.	.
cord-002209-xs6qigg4	195	1	,	,	,
cord-002209-xs6qigg4	195	2	2013	2013	CD
cord-002209-xs6qigg4	195	3	)	)	-RRB-
cord-002209-xs6qigg4	195	4	.	.	.
cord-002209-xs6qigg4	196	1	Evidence	evidence	NN
cord-002209-xs6qigg4	196	2	has	have	VBZ
cord-002209-xs6qigg4	196	3	shown	show	VBN
cord-002209-xs6qigg4	196	4	that	that	IN
cord-002209-xs6qigg4	196	5	microglia	microglia	JJ
cord-002209-xs6qigg4	196	6	secrete	secrete	JJ
cord-002209-xs6qigg4	196	7	immune	immune	JJ
cord-002209-xs6qigg4	196	8	factors	factor	NNS
cord-002209-xs6qigg4	196	9	that	that	WDT
cord-002209-xs6qigg4	196	10	play	play	VBP
cord-002209-xs6qigg4	196	11	an	an	DT
cord-002209-xs6qigg4	196	12	important	important	JJ
cord-002209-xs6qigg4	196	13	role	role	NN
cord-002209-xs6qigg4	196	14	in	in	IN
cord-002209-xs6qigg4	196	15	synaptic	synaptic	JJ
cord-002209-xs6qigg4	196	16	connections	connection	NNS
cord-002209-xs6qigg4	196	17	and	and	CC
cord-002209-xs6qigg4	196	18	illustrates	illustrate	VBZ
cord-002209-xs6qigg4	196	19	the	the	DT
cord-002209-xs6qigg4	196	20	complexity	complexity	NN
cord-002209-xs6qigg4	196	21	of	of	IN
cord-002209-xs6qigg4	196	22	cross	cross	NN
cord-002209-xs6qigg4	196	23	-	-	NN
cord-002209-xs6qigg4	196	24	talk	talk	NN
cord-002209-xs6qigg4	196	25	between	between	IN
cord-002209-xs6qigg4	196	26	neural	neural	JJ
cord-002209-xs6qigg4	196	27	cells	cell	NNS
cord-002209-xs6qigg4	196	28	and	and	CC
cord-002209-xs6qigg4	196	29	the	the	DT
cord-002209-xs6qigg4	196	30	immune	immune	JJ
cord-002209-xs6qigg4	196	31	system	system	NN
cord-002209-xs6qigg4	196	32	.	.	.
cord-002209-xs6qigg4	197	1	These	these	DT
cord-002209-xs6qigg4	197	2	researchers	researcher	NNS
cord-002209-xs6qigg4	197	3	have	have	VBP
cord-002209-xs6qigg4	197	4	suggested	suggest	VBN
cord-002209-xs6qigg4	197	5	a	a	DT
cord-002209-xs6qigg4	197	6	change	change	NN
cord-002209-xs6qigg4	197	7	in	in	IN
cord-002209-xs6qigg4	197	8	name	name	NN
cord-002209-xs6qigg4	197	9	from	from	IN
cord-002209-xs6qigg4	197	10	tripartite	tripartite	JJ
cord-002209-xs6qigg4	197	11	synapse	synapse	NN
cord-002209-xs6qigg4	197	12	to	to	IN
cord-002209-xs6qigg4	197	13	the	the	DT
cord-002209-xs6qigg4	197	14	quad	quad	JJ
cord-002209-xs6qigg4	197	15	-	-	HYPH
cord-002209-xs6qigg4	197	16	partite	partite	JJ
cord-002209-xs6qigg4	197	17	synapse	synapse	NN
cord-002209-xs6qigg4	198	1	(	(	-LRB-
cord-002209-xs6qigg4	198	2	Schafer	Schafer	NNP
cord-002209-xs6qigg4	198	3	et	et	NNP
cord-002209-xs6qigg4	198	4	al	al	NNP
cord-002209-xs6qigg4	198	5	.	.	.
cord-002209-xs6qigg4	199	1	,	,	,
cord-002209-xs6qigg4	199	2	2013	2013	CD
cord-002209-xs6qigg4	199	3	;	;	:
cord-002209-xs6qigg4	199	4	Wu	Wu	NNP
cord-002209-xs6qigg4	199	5	et	et	NNP
cord-002209-xs6qigg4	199	6	al	al	NNP
cord-002209-xs6qigg4	199	7	.	.	NNP
cord-002209-xs6qigg4	199	8	,	,	,
cord-002209-xs6qigg4	199	9	2015	2015	CD
cord-002209-xs6qigg4	199	10	)	)	-RRB-
cord-002209-xs6qigg4	199	11	.	.	.
cord-002209-xs6qigg4	200	1	In	in	IN
cord-002209-xs6qigg4	200	2	addition	addition	NN
cord-002209-xs6qigg4	200	3	to	to	IN
cord-002209-xs6qigg4	200	4	playing	play	VBG
cord-002209-xs6qigg4	200	5	a	a	DT
cord-002209-xs6qigg4	200	6	role	role	NN
cord-002209-xs6qigg4	200	7	in	in	IN
cord-002209-xs6qigg4	200	8	synaptic	synaptic	JJ
cord-002209-xs6qigg4	200	9	signal	signal	NN
cord-002209-xs6qigg4	200	10	transmission	transmission	NN
cord-002209-xs6qigg4	200	11	,	,	,
cord-002209-xs6qigg4	200	12	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	200	13	can	can	MD
cord-002209-xs6qigg4	200	14	also	also	RB
cord-002209-xs6qigg4	200	15	modulate	modulate	VB
cord-002209-xs6qigg4	200	16	synapses	synapsis	NNS
cord-002209-xs6qigg4	200	17	.	.	.
cord-002209-xs6qigg4	201	1	It	-PRON-	PRP
cord-002209-xs6qigg4	201	2	has	have	VBZ
cord-002209-xs6qigg4	201	3	been	be	VBN
cord-002209-xs6qigg4	201	4	demonstrated	demonstrate	VBN
cord-002209-xs6qigg4	201	5	that	that	IN
cord-002209-xs6qigg4	201	6	astrocytes	astrocytes	RB
cord-002209-xs6qigg4	201	7	secrete	secrete	JJ
cord-002209-xs6qigg4	201	8	molecules	molecule	NNS
cord-002209-xs6qigg4	201	9	such	such	JJ
cord-002209-xs6qigg4	201	10	as	as	IN
cord-002209-xs6qigg4	201	11	thrombospondins	thrombospondin	NNS
cord-002209-xs6qigg4	201	12	that	that	WDT
cord-002209-xs6qigg4	201	13	might	may	MD
cord-002209-xs6qigg4	201	14	be	be	VB
cord-002209-xs6qigg4	201	15	required	require	VBN
cord-002209-xs6qigg4	201	16	for	for	IN
cord-002209-xs6qigg4	201	17	the	the	DT
cord-002209-xs6qigg4	201	18	formation	formation	NN
cord-002209-xs6qigg4	201	19	,	,	,
cord-002209-xs6qigg4	201	20	function	function	NN
cord-002209-xs6qigg4	201	21	and	and	CC
cord-002209-xs6qigg4	201	22	pruning	pruning	NN
cord-002209-xs6qigg4	201	23	of	of	IN
cord-002209-xs6qigg4	201	24	developing	develop	VBG
cord-002209-xs6qigg4	201	25	synapses	synapsis	NNS
cord-002209-xs6qigg4	201	26	(	(	-LRB-
cord-002209-xs6qigg4	201	27	Ullian	Ullian	NNP
cord-002209-xs6qigg4	201	28	et	et	NNP
cord-002209-xs6qigg4	201	29	al	al	NNP
cord-002209-xs6qigg4	201	30	.	.	NNP
cord-002209-xs6qigg4	201	31	,	,	,
cord-002209-xs6qigg4	201	32	2001	2001	CD
cord-002209-xs6qigg4	201	33	;	;	:
cord-002209-xs6qigg4	201	34	Christopherson	Christopherson	NNP
cord-002209-xs6qigg4	201	35	et	et	NNP
cord-002209-xs6qigg4	201	36	al	al	NNP
cord-002209-xs6qigg4	201	37	.	.	NNP
cord-002209-xs6qigg4	201	38	,	,	,
cord-002209-xs6qigg4	201	39	2005	2005	CD
cord-002209-xs6qigg4	201	40	)	)	-RRB-
cord-002209-xs6qigg4	201	41	.	.	.
cord-002209-xs6qigg4	202	1	Both	both	DT
cord-002209-xs6qigg4	202	2	presynaptic	presynaptic	JJ
cord-002209-xs6qigg4	202	3	and	and	CC
cord-002209-xs6qigg4	202	4	postsynaptic	postsynaptic	JJ
cord-002209-xs6qigg4	202	5	activity	activity	NN
cord-002209-xs6qigg4	202	6	in	in	IN
cord-002209-xs6qigg4	202	7	purified	purify	VBN
cord-002209-xs6qigg4	202	8	rat	rat	NN
cord-002209-xs6qigg4	202	9	retinal	retinal	JJ
cord-002209-xs6qigg4	202	10	ganglion	ganglion	NN
cord-002209-xs6qigg4	202	11	cultures	culture	NNS
cord-002209-xs6qigg4	202	12	have	have	VBP
cord-002209-xs6qigg4	202	13	been	be	VBN
cord-002209-xs6qigg4	202	14	enhanced	enhance	VBN
cord-002209-xs6qigg4	202	15	in	in	IN
cord-002209-xs6qigg4	202	16	the	the	DT
cord-002209-xs6qigg4	202	17	presence	presence	NN
cord-002209-xs6qigg4	202	18	of	of	IN
cord-002209-xs6qigg4	202	19	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	202	20	;	;	:
cord-002209-xs6qigg4	202	21	and	and	CC
cord-002209-xs6qigg4	202	22	immunohistochemistry	immunohistochemistry	NN
cord-002209-xs6qigg4	202	23	of	of	IN
cord-002209-xs6qigg4	202	24	rat	rat	NN
cord-002209-xs6qigg4	202	25	brain	brain	NN
cord-002209-xs6qigg4	202	26	cryosections	cryosection	NNS
cord-002209-xs6qigg4	202	27	from	from	IN
cord-002209-xs6qigg4	202	28	various	various	JJ
cord-002209-xs6qigg4	202	29	developmental	developmental	JJ
cord-002209-xs6qigg4	202	30	stages	stage	NNS
cord-002209-xs6qigg4	202	31	have	have	VBP
cord-002209-xs6qigg4	202	32	shown	show	VBN
cord-002209-xs6qigg4	202	33	that	that	IN
cord-002209-xs6qigg4	202	34	glial	glial	JJ
cord-002209-xs6qigg4	202	35	generation	generation	NN
cord-002209-xs6qigg4	202	36	precedes	precede	VBZ
cord-002209-xs6qigg4	202	37	the	the	DT
cord-002209-xs6qigg4	202	38	appearance	appearance	NN
cord-002209-xs6qigg4	202	39	of	of	IN
cord-002209-xs6qigg4	202	40	synapses	synapsis	NNS
cord-002209-xs6qigg4	202	41	(	(	-LRB-
cord-002209-xs6qigg4	202	42	Ullian	Ullian	NNP
cord-002209-xs6qigg4	202	43	et	et	NNP
cord-002209-xs6qigg4	202	44	al	al	NNP
cord-002209-xs6qigg4	202	45	.	.	NNP
cord-002209-xs6qigg4	202	46	,	,	,
cord-002209-xs6qigg4	202	47	2001	2001	CD
cord-002209-xs6qigg4	202	48	)	)	-RRB-
cord-002209-xs6qigg4	202	49	.	.	.
cord-002209-xs6qigg4	203	1	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	203	2	might	may	MD
cord-002209-xs6qigg4	203	3	also	also	RB
cord-002209-xs6qigg4	203	4	be	be	VB
cord-002209-xs6qigg4	203	5	functional	functional	JJ
cord-002209-xs6qigg4	203	6	in	in	IN
cord-002209-xs6qigg4	203	7	synaptic	synaptic	JJ
cord-002209-xs6qigg4	203	8	remodelling	remodelling	NN
cord-002209-xs6qigg4	203	9	and	and	CC
cord-002209-xs6qigg4	203	10	pruning	pruning	NN
cord-002209-xs6qigg4	203	11	in	in	RP
cord-002209-xs6qigg4	203	12	healthy	healthy	JJ
cord-002209-xs6qigg4	203	13	or	or	CC
cord-002209-xs6qigg4	203	14	diseased	diseased	JJ
cord-002209-xs6qigg4	203	15	adult	adult	NN
cord-002209-xs6qigg4	203	16	CNS	CNS	NNP
cord-002209-xs6qigg4	203	17	(	(	-LRB-
cord-002209-xs6qigg4	203	18	Barres	Barres	NNPS
cord-002209-xs6qigg4	203	19	,	,	,
cord-002209-xs6qigg4	203	20	2008	2008	CD
cord-002209-xs6qigg4	203	21	)	)	-RRB-
cord-002209-xs6qigg4	203	22	.	.	.
cord-002209-xs6qigg4	204	1	Because	because	IN
cord-002209-xs6qigg4	204	2	synaptic	synaptic	JJ
cord-002209-xs6qigg4	204	3	signal	signal	NN
cord-002209-xs6qigg4	204	4	transmission	transmission	NN
cord-002209-xs6qigg4	204	5	can	can	MD
cord-002209-xs6qigg4	204	6	trigger	trigger	VB
cord-002209-xs6qigg4	204	7	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	204	8	to	to	TO
cord-002209-xs6qigg4	204	9	secrete	secrete	VB
cord-002209-xs6qigg4	204	10	the	the	DT
cord-002209-xs6qigg4	204	11	cytokine	cytokine	NN
cord-002209-xs6qigg4	204	12	LIF	LIF	NNP
cord-002209-xs6qigg4	204	13	,	,	,
cord-002209-xs6qigg4	204	14	which	which	WDT
cord-002209-xs6qigg4	204	15	in	in	IN
cord-002209-xs6qigg4	204	16	turn	turn	NN
cord-002209-xs6qigg4	204	17	increases	increase	VBZ
cord-002209-xs6qigg4	204	18	the	the	DT
cord-002209-xs6qigg4	204	19	number	number	NN
cord-002209-xs6qigg4	204	20	of	of	IN
cord-002209-xs6qigg4	204	21	myelinated	myelinated	JJ
cord-002209-xs6qigg4	204	22	axons	axon	NNS
cord-002209-xs6qigg4	204	23	in	in	IN
cord-002209-xs6qigg4	204	24	dorsal	dorsal	JJ
cord-002209-xs6qigg4	204	25	root	root	NN
cord-002209-xs6qigg4	204	26	ganglion	ganglion	NN
cord-002209-xs6qigg4	204	27	cultures	culture	NNS
cord-002209-xs6qigg4	204	28	co	co	VBP
cord-002209-xs6qigg4	204	29	-	-	JJ
cord-002209-xs6qigg4	204	30	cultured	cultured	JJ
cord-002209-xs6qigg4	204	31	with	with	IN
cord-002209-xs6qigg4	204	32	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	204	33	(	(	-LRB-
cord-002209-xs6qigg4	204	34	Ishibashi	Ishibashi	NNP
cord-002209-xs6qigg4	204	35	et	et	NNP
cord-002209-xs6qigg4	204	36	al	al	NNP
cord-002209-xs6qigg4	204	37	.	.	NNP
cord-002209-xs6qigg4	204	38	,	,	,
cord-002209-xs6qigg4	204	39	2006	2006	CD
cord-002209-xs6qigg4	204	40	)	)	-RRB-
cord-002209-xs6qigg4	204	41	,	,	.
cord-002209-xs6qigg4	205	1	the	the	DT
cord-002209-xs6qigg4	205	2	support	support	NN
cord-002209-xs6qigg4	205	3	and	and	CC
cord-002209-xs6qigg4	205	4	maintenance	maintenance	NN
cord-002209-xs6qigg4	205	5	of	of	IN
cord-002209-xs6qigg4	205	6	healthy	healthy	JJ
cord-002209-xs6qigg4	205	7	signal	signal	NN
cord-002209-xs6qigg4	205	8	transmission	transmission	NN
cord-002209-xs6qigg4	205	9	appears	appear	VBZ
cord-002209-xs6qigg4	205	10	important	important	JJ
cord-002209-xs6qigg4	205	11	for	for	IN
cord-002209-xs6qigg4	205	12	the	the	DT
cord-002209-xs6qigg4	205	13	regulation	regulation	NN
cord-002209-xs6qigg4	205	14	of	of	IN
cord-002209-xs6qigg4	205	15	myelination	myelination	NN
cord-002209-xs6qigg4	205	16	.	.	.
cord-002209-xs6qigg4	206	1	Furthermore	furthermore	RB
cord-002209-xs6qigg4	206	2	,	,	,
cord-002209-xs6qigg4	206	3	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	206	4	may	may	MD
cord-002209-xs6qigg4	206	5	contribute	contribute	VB
cord-002209-xs6qigg4	206	6	to	to	IN
cord-002209-xs6qigg4	206	7	synaptic	synaptic	JJ
cord-002209-xs6qigg4	206	8	transmission	transmission	NN
cord-002209-xs6qigg4	206	9	by	by	IN
cord-002209-xs6qigg4	206	10	supporting	support	VBG
cord-002209-xs6qigg4	206	11	maintenance	maintenance	NN
cord-002209-xs6qigg4	206	12	of	of	IN
cord-002209-xs6qigg4	206	13	the	the	DT
cord-002209-xs6qigg4	206	14	synaptic	synaptic	JJ
cord-002209-xs6qigg4	206	15	interstitial	interstitial	JJ
cord-002209-xs6qigg4	206	16	fluid	fluid	NN
cord-002209-xs6qigg4	206	17	by	by	IN
cord-002209-xs6qigg4	206	18	regulating	regulate	VBG
cord-002209-xs6qigg4	206	19	ion	ion	NN
cord-002209-xs6qigg4	206	20	,	,	,
cord-002209-xs6qigg4	206	21	pH	ph	NN
cord-002209-xs6qigg4	206	22	and	and	CC
cord-002209-xs6qigg4	206	23	transmitter	transmitter	NN
cord-002209-xs6qigg4	206	24	homeostasis	homeostasis	NN
cord-002209-xs6qigg4	206	25	.	.	.
cord-002209-xs6qigg4	207	1	Astrocyte	Astrocyte	NNP
cord-002209-xs6qigg4	207	2	processes	process	NNS
cord-002209-xs6qigg4	207	3	contain	contain	VBP
cord-002209-xs6qigg4	207	4	transporters	transporter	NNS
cord-002209-xs6qigg4	207	5	for	for	IN
cord-002209-xs6qigg4	207	6	potassium	potassium	NN
cord-002209-xs6qigg4	207	7	uptake	uptake	NN
cord-002209-xs6qigg4	207	8	and	and	CC
cord-002209-xs6qigg4	207	9	aquaporin	aquaporin	NNP
cord-002209-xs6qigg4	207	10	4	4	CD
cord-002209-xs6qigg4	207	11	water	water	NN
cord-002209-xs6qigg4	207	12	channels	channel	NNS
cord-002209-xs6qigg4	207	13	(	(	-LRB-
cord-002209-xs6qigg4	207	14	Nielsen	Nielsen	NNP
cord-002209-xs6qigg4	207	15	et	et	NNP
cord-002209-xs6qigg4	207	16	al	al	NNP
cord-002209-xs6qigg4	207	17	.	.	NNP
cord-002209-xs6qigg4	207	18	,	,	,
cord-002209-xs6qigg4	207	19	1997	1997	CD
cord-002209-xs6qigg4	207	20	;	;	:
cord-002209-xs6qigg4	207	21	Rash	Rash	NNP
cord-002209-xs6qigg4	207	22	et	et	FW
cord-002209-xs6qigg4	207	23	al	al	NNP
cord-002209-xs6qigg4	207	24	.	.	.
cord-002209-xs6qigg4	208	1	,	,	,
cord-002209-xs6qigg4	208	2	1998	1998	CD
cord-002209-xs6qigg4	208	3	;	;	:
cord-002209-xs6qigg4	208	4	Amiry	Amiry	NNP
cord-002209-xs6qigg4	208	5	-	-	HYPH
cord-002209-xs6qigg4	208	6	Moghaddam	Moghaddam	NNP
cord-002209-xs6qigg4	208	7	et	et	NNP
cord-002209-xs6qigg4	208	8	al	al	NNP
cord-002209-xs6qigg4	208	9	.	.	NNP
cord-002209-xs6qigg4	208	10	,	,	,
cord-002209-xs6qigg4	208	11	2003	2003	CD
cord-002209-xs6qigg4	209	1	;	;	:
cord-002209-xs6qigg4	209	2	Solenov	Solenov	NNP
cord-002209-xs6qigg4	209	3	et	et	NNP
cord-002209-xs6qigg4	209	4	al	al	NNP
cord-002209-xs6qigg4	209	5	.	.	NNP
cord-002209-xs6qigg4	209	6	,	,	,
cord-002209-xs6qigg4	209	7	2004	2004	CD
cord-002209-xs6qigg4	209	8	)	)	-RRB-
cord-002209-xs6qigg4	209	9	,	,	,
cord-002209-xs6qigg4	209	10	which	which	WDT
cord-002209-xs6qigg4	209	11	maintain	maintain	VBP
cord-002209-xs6qigg4	209	12	the	the	DT
cord-002209-xs6qigg4	209	13	transmitter	transmitter	NN
cord-002209-xs6qigg4	209	14	homeostasis	homeostasis	NN
cord-002209-xs6qigg4	209	15	of	of	IN
cord-002209-xs6qigg4	209	16	the	the	DT
cord-002209-xs6qigg4	209	17	synaptic	synaptic	JJ
cord-002209-xs6qigg4	209	18	interstitial	interstitial	JJ
cord-002209-xs6qigg4	209	19	fluid	fluid	NN
cord-002209-xs6qigg4	209	20	(	(	-LRB-
cord-002209-xs6qigg4	209	21	Steinhäuser	Steinhäuser	NNP
cord-002209-xs6qigg4	209	22	et	et	NNP
cord-002209-xs6qigg4	209	23	al	al	NNP
cord-002209-xs6qigg4	209	24	.	.	NNP
cord-002209-xs6qigg4	209	25	,	,	,
cord-002209-xs6qigg4	209	26	1994	1994	CD
cord-002209-xs6qigg4	209	27	;	;	:
cord-002209-xs6qigg4	209	28	Gundersen	Gundersen	NNP
cord-002209-xs6qigg4	209	29	et	et	NNP
cord-002209-xs6qigg4	209	30	al	al	NNP
cord-002209-xs6qigg4	209	31	.	.	.
cord-002209-xs6qigg4	210	1	,	,	,
cord-002209-xs6qigg4	210	2	1996	1996	CD
cord-002209-xs6qigg4	210	3	;	;	:
cord-002209-xs6qigg4	210	4	Mennerick	Mennerick	NNP
cord-002209-xs6qigg4	210	5	et	et	NNP
cord-002209-xs6qigg4	210	6	al	al	NNP
cord-002209-xs6qigg4	210	7	.	.	.
cord-002209-xs6qigg4	211	1	,	,	,
cord-002209-xs6qigg4	211	2	1996	1996	CD
cord-002209-xs6qigg4	211	3	;	;	:
cord-002209-xs6qigg4	211	4	Bergles	Bergles	NNP
cord-002209-xs6qigg4	211	5	and	and	CC
cord-002209-xs6qigg4	211	6	Jahr	Jahr	NNP
cord-002209-xs6qigg4	211	7	,	,	,
cord-002209-xs6qigg4	211	8	1997	1997	CD
cord-002209-xs6qigg4	211	9	;	;	:
cord-002209-xs6qigg4	211	10	Fujita	Fujita	NNP
cord-002209-xs6qigg4	211	11	et	et	NNP
cord-002209-xs6qigg4	211	12	al	al	NNP
cord-002209-xs6qigg4	211	13	.	.	NNP
cord-002209-xs6qigg4	211	14	,	,	,
cord-002209-xs6qigg4	211	15	1999	1999	CD
cord-002209-xs6qigg4	211	16	)	)	-RRB-
cord-002209-xs6qigg4	211	17	.	.	.
cord-002209-xs6qigg4	212	1	Connexin	Connexin	NNP
cord-002209-xs6qigg4	212	2	channels	channel	NNS
cord-002209-xs6qigg4	212	3	and	and	CC
cord-002209-xs6qigg4	212	4	connexin	connexin	NN
cord-002209-xs6qigg4	212	5	proteins	protein	NNS
cord-002209-xs6qigg4	212	6	are	be	VBP
cord-002209-xs6qigg4	212	7	important	important	JJ
cord-002209-xs6qigg4	212	8	candidates	candidate	NNS
cord-002209-xs6qigg4	212	9	which	which	WDT
cord-002209-xs6qigg4	212	10	play	play	VBP
cord-002209-xs6qigg4	212	11	a	a	DT
cord-002209-xs6qigg4	212	12	role	role	NN
cord-002209-xs6qigg4	212	13	in	in	IN
cord-002209-xs6qigg4	212	14	the	the	DT
cord-002209-xs6qigg4	212	15	regulation	regulation	NN
cord-002209-xs6qigg4	212	16	of	of	IN
cord-002209-xs6qigg4	212	17	neuronal	neuronal	JJ
cord-002209-xs6qigg4	212	18	activity	activity	NN
cord-002209-xs6qigg4	212	19	and	and	CC
cord-002209-xs6qigg4	212	20	survival	survival	NN
cord-002209-xs6qigg4	212	21	.	.	.
cord-002209-xs6qigg4	213	1	For	for	IN
cord-002209-xs6qigg4	213	2	example	example	NN
cord-002209-xs6qigg4	213	3	,	,	,
cord-002209-xs6qigg4	213	4	astroglial	astroglial	NNP
cord-002209-xs6qigg4	213	5	connexins	connexins	NNP
cord-002209-xs6qigg4	213	6	decrease	decrease	VBP
cord-002209-xs6qigg4	213	7	neuronal	neuronal	JJ
cord-002209-xs6qigg4	213	8	excitability	excitability	NN
cord-002209-xs6qigg4	213	9	by	by	IN
cord-002209-xs6qigg4	213	10	removing	remove	VBG
cord-002209-xs6qigg4	213	11	extracellular	extracellular	JJ
cord-002209-xs6qigg4	213	12	potassium	potassium	NN
cord-002209-xs6qigg4	213	13	and	and	CC
cord-002209-xs6qigg4	213	14	glutamate	glutamate	NN
cord-002209-xs6qigg4	213	15	;	;	:
cord-002209-xs6qigg4	213	16	while	while	IN
cord-002209-xs6qigg4	213	17	also	also	RB
cord-002209-xs6qigg4	213	18	providing	provide	VBG
cord-002209-xs6qigg4	213	19	metabolic	metabolic	JJ
cord-002209-xs6qigg4	213	20	supply	supply	NN
cord-002209-xs6qigg4	213	21	to	to	IN
cord-002209-xs6qigg4	213	22	neurons	neuron	NNS
cord-002209-xs6qigg4	213	23	(	(	-LRB-
cord-002209-xs6qigg4	213	24	Wallraff	Wallraff	NNP
cord-002209-xs6qigg4	213	25	et	et	NNP
cord-002209-xs6qigg4	213	26	al	al	NNP
cord-002209-xs6qigg4	213	27	.	.	NNP
cord-002209-xs6qigg4	213	28	,	,	,
cord-002209-xs6qigg4	213	29	2006	2006	CD
cord-002209-xs6qigg4	213	30	;	;	.
cord-002209-xs6qigg4	214	1	Rouach	Rouach	NNP
cord-002209-xs6qigg4	214	2	et	et	NNP
cord-002209-xs6qigg4	214	3	al	al	NNP
cord-002209-xs6qigg4	214	4	.	.	NNP
cord-002209-xs6qigg4	214	5	,	,	,
cord-002209-xs6qigg4	214	6	2008	2008	CD
cord-002209-xs6qigg4	214	7	;	;	:
cord-002209-xs6qigg4	214	8	Froger	Froger	NNP
cord-002209-xs6qigg4	214	9	et	et	NNP
cord-002209-xs6qigg4	214	10	al	al	NNP
cord-002209-xs6qigg4	214	11	.	.	.
cord-002209-xs6qigg4	214	12	2010	2010	CD
cord-002209-xs6qigg4	215	1	;	;	:
cord-002209-xs6qigg4	215	2	Pannasch	Pannasch	NNP
cord-002209-xs6qigg4	215	3	et	et	NNP
cord-002209-xs6qigg4	215	4	al	al	NNP
cord-002209-xs6qigg4	215	5	.	.	NNP
cord-002209-xs6qigg4	215	6	,	,	,
cord-002209-xs6qigg4	215	7	2011	2011	CD
cord-002209-xs6qigg4	215	8	)	)	-RRB-
cord-002209-xs6qigg4	215	9	.	.	.
cord-002209-xs6qigg4	216	1	On	on	IN
cord-002209-xs6qigg4	216	2	the	the	DT
cord-002209-xs6qigg4	216	3	other	other	JJ
cord-002209-xs6qigg4	216	4	hand	hand	NN
cord-002209-xs6qigg4	216	5	,	,	,
cord-002209-xs6qigg4	216	6	the	the	DT
cord-002209-xs6qigg4	216	7	elevation	elevation	NN
cord-002209-xs6qigg4	216	8	of	of	IN
cord-002209-xs6qigg4	216	9	connexin	connexin	JJ
cord-002209-xs6qigg4	216	10	expression	expression	NN
cord-002209-xs6qigg4	216	11	at	at	IN
cord-002209-xs6qigg4	216	12	lesion	lesion	NN
cord-002209-xs6qigg4	216	13	sites	site	NNS
cord-002209-xs6qigg4	216	14	in	in	IN
cord-002209-xs6qigg4	216	15	CNS	CNS	NNP
cord-002209-xs6qigg4	216	16	pathologies	pathology	NNS
cord-002209-xs6qigg4	216	17	might	may	MD
cord-002209-xs6qigg4	216	18	also	also	RB
cord-002209-xs6qigg4	216	19	be	be	VB
cord-002209-xs6qigg4	216	20	associated	associate	VBN
cord-002209-xs6qigg4	216	21	with	with	IN
cord-002209-xs6qigg4	216	22	other	other	JJ
cord-002209-xs6qigg4	216	23	,	,	,
cord-002209-xs6qigg4	216	24	possibly	possibly	RB
cord-002209-xs6qigg4	216	25	protective	protective	JJ
cord-002209-xs6qigg4	216	26	,	,	,
cord-002209-xs6qigg4	216	27	roles	role	NNS
cord-002209-xs6qigg4	216	28	(	(	-LRB-
cord-002209-xs6qigg4	216	29	Nagy	Nagy	NNP
cord-002209-xs6qigg4	216	30	et	et	NNP
cord-002209-xs6qigg4	216	31	al	al	NNP
cord-002209-xs6qigg4	216	32	.	.	NNP
cord-002209-xs6qigg4	216	33	,	,	,
cord-002209-xs6qigg4	216	34	1996	1996	CD
cord-002209-xs6qigg4	216	35	;	;	:
cord-002209-xs6qigg4	216	36	Koulakoff	Koulakoff	NNP
cord-002209-xs6qigg4	216	37	et	et	FW
cord-002209-xs6qigg4	216	38	al	al	NNP
cord-002209-xs6qigg4	216	39	.	.	NNP
cord-002209-xs6qigg4	216	40	,	,	,
cord-002209-xs6qigg4	216	41	2008	2008	CD
cord-002209-xs6qigg4	216	42	;	;	.
cord-002209-xs6qigg4	217	1	Kuchibhotla	Kuchibhotla	NNP
cord-002209-xs6qigg4	217	2	et	et	FW
cord-002209-xs6qigg4	217	3	al	al	NNP
cord-002209-xs6qigg4	217	4	.	.	.
cord-002209-xs6qigg4	218	1	,	,	,
cord-002209-xs6qigg4	218	2	2009	2009	CD
cord-002209-xs6qigg4	218	3	;	;	:
cord-002209-xs6qigg4	218	4	Mei	Mei	NNP
cord-002209-xs6qigg4	218	5	et	et	NNP
cord-002209-xs6qigg4	218	6	al	al	NNP
cord-002209-xs6qigg4	218	7	.	.	NNP
cord-002209-xs6qigg4	218	8	,	,	,
cord-002209-xs6qigg4	218	9	2010	2010	CD
cord-002209-xs6qigg4	218	10	;	;	:
cord-002209-xs6qigg4	218	11	Karpuk	Karpuk	NNP
cord-002209-xs6qigg4	218	12	et	et	NNP
cord-002209-xs6qigg4	218	13	al	al	NNP
cord-002209-xs6qigg4	218	14	.	.	NNP
cord-002209-xs6qigg4	218	15	,	,	,
cord-002209-xs6qigg4	218	16	2011	2011	CD
cord-002209-xs6qigg4	218	17	)	)	-RRB-
cord-002209-xs6qigg4	218	18	.	.	.
cord-002209-xs6qigg4	219	1	Studies	study	NNS
cord-002209-xs6qigg4	219	2	using	use	VBG
cord-002209-xs6qigg4	219	3	connexin	connexin	JJ
cord-002209-xs6qigg4	219	4	knockout	knockout	NN
cord-002209-xs6qigg4	219	5	animals	animal	NNS
cord-002209-xs6qigg4	219	6	allude	allude	VBP
cord-002209-xs6qigg4	219	7	to	to	IN
cord-002209-xs6qigg4	219	8	the	the	DT
cord-002209-xs6qigg4	219	9	importance	importance	NN
cord-002209-xs6qigg4	219	10	of	of	IN
cord-002209-xs6qigg4	219	11	connexins	connexin	NNS
cord-002209-xs6qigg4	219	12	in	in	IN
cord-002209-xs6qigg4	219	13	promoting	promote	VBG
cord-002209-xs6qigg4	219	14	communication	communication	NN
cord-002209-xs6qigg4	219	15	between	between	IN
cord-002209-xs6qigg4	219	16	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	219	17	and	and	CC
cord-002209-xs6qigg4	219	18	between	between	IN
cord-002209-xs6qigg4	219	19	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	219	20	and	and	CC
cord-002209-xs6qigg4	219	21	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	219	22	on	on	IN
cord-002209-xs6qigg4	219	23	myelin	myelin	NN
cord-002209-xs6qigg4	219	24	integrity	integrity	NN
cord-002209-xs6qigg4	219	25	.	.	.
cord-002209-xs6qigg4	220	1	Myelin	myelin	JJ
cord-002209-xs6qigg4	220	2	damage	damage	NN
cord-002209-xs6qigg4	220	3	has	have	VBZ
cord-002209-xs6qigg4	220	4	been	be	VBN
cord-002209-xs6qigg4	220	5	observed	observe	VBN
cord-002209-xs6qigg4	220	6	in	in	IN
cord-002209-xs6qigg4	220	7	Cx47	Cx47	NNP
cord-002209-xs6qigg4	220	8	,	,	,
cord-002209-xs6qigg4	220	9	Cx43/	Cx43/	NNP
cord-002209-xs6qigg4	221	1	Cx30	cx30	RB
cord-002209-xs6qigg4	222	1	and	and	CC
cord-002209-xs6qigg4	222	2	Cx30/	Cx30/	NNP
cord-002209-xs6qigg4	223	1	Cx47	Cx47	NNP
cord-002209-xs6qigg4	224	1	single	single	JJ
cord-002209-xs6qigg4	224	2	/	/	SYM
cord-002209-xs6qigg4	224	3	double	double	JJ
cord-002209-xs6qigg4	224	4	knockout	knockout	NN
cord-002209-xs6qigg4	224	5	mice	mouse	NNS
cord-002209-xs6qigg4	225	1	(	(	-LRB-
cord-002209-xs6qigg4	225	2	Menichella	Menichella	NNP
cord-002209-xs6qigg4	225	3	et	et	NNP
cord-002209-xs6qigg4	225	4	al	al	NNP
cord-002209-xs6qigg4	225	5	.	.	NNP
cord-002209-xs6qigg4	225	6	,	,	,
cord-002209-xs6qigg4	225	7	2003	2003	CD
cord-002209-xs6qigg4	226	1	;	;	:
cord-002209-xs6qigg4	226	2	Odermatt	Odermatt	NNP
cord-002209-xs6qigg4	226	3	et	et	NNP
cord-002209-xs6qigg4	226	4	al	al	NNP
cord-002209-xs6qigg4	226	5	.	.	NNP
cord-002209-xs6qigg4	226	6	,	,	,
cord-002209-xs6qigg4	226	7	2003	2003	CD
cord-002209-xs6qigg4	226	8	;	;	:
cord-002209-xs6qigg4	226	9	Lutz	Lutz	NNP
cord-002209-xs6qigg4	226	10	et	et	NNP
cord-002209-xs6qigg4	226	11	al	al	NNP
cord-002209-xs6qigg4	226	12	.	.	.
cord-002209-xs6qigg4	227	1	,	,	,
cord-002209-xs6qigg4	227	2	2009	2009	CD
cord-002209-xs6qigg4	227	3	;	;	:
cord-002209-xs6qigg4	227	4	Tress	Tress	NNP
cord-002209-xs6qigg4	227	5	et	et	FW
cord-002209-xs6qigg4	227	6	al	al	NNP
cord-002209-xs6qigg4	227	7	.	.	NNP
cord-002209-xs6qigg4	227	8	,	,	,
cord-002209-xs6qigg4	227	9	2012	2012	CD
cord-002209-xs6qigg4	227	10	)	)	-RRB-
cord-002209-xs6qigg4	227	11	.	.	.
cord-002209-xs6qigg4	228	1	Interestingly	interestingly	RB
cord-002209-xs6qigg4	228	2	,	,	,
cord-002209-xs6qigg4	228	3	the	the	DT
cord-002209-xs6qigg4	228	4	level	level	NN
cord-002209-xs6qigg4	228	5	of	of	IN
cord-002209-xs6qigg4	228	6	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	228	7	gap	gap	NNP
cord-002209-xs6qigg4	228	8	junction	junction	NNP
cord-002209-xs6qigg4	228	9	connexins	connexins	NNP
cord-002209-xs6qigg4	228	10	Cx47	Cx47	NNP
cord-002209-xs6qigg4	228	11	and	and	CC
cord-002209-xs6qigg4	228	12	Cx32	Cx32	NNP
cord-002209-xs6qigg4	228	13	were	be	VBD
cord-002209-xs6qigg4	228	14	reduced	reduce	VBN
cord-002209-xs6qigg4	228	15	both	both	CC
cord-002209-xs6qigg4	228	16	within	within	IN
cord-002209-xs6qigg4	228	17	and	and	CC
cord-002209-xs6qigg4	228	18	around	around	IN
cord-002209-xs6qigg4	228	19	lesions	lesion	NNS
cord-002209-xs6qigg4	228	20	during	during	IN
cord-002209-xs6qigg4	228	21	early	early	JJ
cord-002209-xs6qigg4	228	22	stages	stage	NNS
cord-002209-xs6qigg4	228	23	of	of	IN
cord-002209-xs6qigg4	228	24	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	228	25	demyelination	demyelination	NN
cord-002209-xs6qigg4	228	26	in	in	IN
cord-002209-xs6qigg4	228	27	EAE	EAE	NNP
cord-002209-xs6qigg4	228	28	mice	mouse	NNS
cord-002209-xs6qigg4	228	29	,	,	,
cord-002209-xs6qigg4	228	30	(	(	-LRB-
cord-002209-xs6qigg4	228	31	Traugott	Traugott	NNP
cord-002209-xs6qigg4	228	32	and	and	CC
cord-002209-xs6qigg4	228	33	Lebon	Lebon	NNP
cord-002209-xs6qigg4	228	34	,	,	,
cord-002209-xs6qigg4	228	35	1988	1988	CD
cord-002209-xs6qigg4	228	36	;	;	:
cord-002209-xs6qigg4	228	37	Tsukada	Tsukada	NNP
cord-002209-xs6qigg4	228	38	et	et	NNP
cord-002209-xs6qigg4	228	39	al	al	NNP
cord-002209-xs6qigg4	228	40	.	.	NNP
cord-002209-xs6qigg4	228	41	,	,	,
cord-002209-xs6qigg4	228	42	1991	1991	CD
cord-002209-xs6qigg4	228	43	;	;	:
cord-002209-xs6qigg4	228	44	Villarroya	Villarroya	NNP
cord-002209-xs6qigg4	228	45	et	et	NNP
cord-002209-xs6qigg4	228	46	al	al	NNP
cord-002209-xs6qigg4	228	47	.	.	NNP
cord-002209-xs6qigg4	228	48	,	,	,
cord-002209-xs6qigg4	228	49	1996	1996	CD
cord-002209-xs6qigg4	228	50	;	;	:
cord-002209-xs6qigg4	228	51	Meeuwsen	Meeuwsen	NNP
cord-002209-xs6qigg4	228	52	et	et	NNP
cord-002209-xs6qigg4	228	53	al	al	NNP
cord-002209-xs6qigg4	228	54	.	.	NNP
cord-002209-xs6qigg4	228	55	,	,	,
cord-002209-xs6qigg4	228	56	2003	2003	CD
cord-002209-xs6qigg4	228	57	)	)	-RRB-
cord-002209-xs6qigg4	228	58	.	.	.
cord-002209-xs6qigg4	229	1	These	these	DT
cord-002209-xs6qigg4	229	2	mice	mouse	NNS
cord-002209-xs6qigg4	229	3	also	also	RB
cord-002209-xs6qigg4	229	4	presented	present	VBD
cord-002209-xs6qigg4	229	5	decreased	decreased	JJ
cord-002209-xs6qigg4	229	6	expression	expression	NN
cord-002209-xs6qigg4	229	7	of	of	IN
cord-002209-xs6qigg4	229	8	Cx43	Cx43	NNP
cord-002209-xs6qigg4	229	9	,	,	,
cord-002209-xs6qigg4	229	10	the	the	DT
cord-002209-xs6qigg4	229	11	major	major	JJ
cord-002209-xs6qigg4	229	12	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	229	13	partner	partner	NN
cord-002209-xs6qigg4	229	14	of	of	IN
cord-002209-xs6qigg4	229	15	Cx47	Cx47	NNP
cord-002209-xs6qigg4	229	16	,	,	,
cord-002209-xs6qigg4	229	17	when	when	WRB
cord-002209-xs6qigg4	229	18	spinal	spinal	JJ
cord-002209-xs6qigg4	229	19	cord	cord	NN
cord-002209-xs6qigg4	229	20	sections	section	NNS
cord-002209-xs6qigg4	229	21	were	be	VBD
cord-002209-xs6qigg4	229	22	analysed	analyse	VBN
cord-002209-xs6qigg4	229	23	immunohistochemically	immunohistochemically	RB
cord-002209-xs6qigg4	229	24	(	(	-LRB-
cord-002209-xs6qigg4	229	25	Markoullis	Markoullis	NNP
cord-002209-xs6qigg4	229	26	et	et	FW
cord-002209-xs6qigg4	229	27	al	al	NNP
cord-002209-xs6qigg4	229	28	.	.	NNP
cord-002209-xs6qigg4	229	29	,	,	,
cord-002209-xs6qigg4	229	30	2012	2012	CD
cord-002209-xs6qigg4	229	31	)	)	-RRB-
cord-002209-xs6qigg4	229	32	.	.	.
cord-002209-xs6qigg4	230	1	Cx43	cx43	VB
cord-002209-xs6qigg4	231	1	expression	expression	NN
cord-002209-xs6qigg4	231	2	was	be	VBD
cord-002209-xs6qigg4	231	3	increased	increase	VBN
cord-002209-xs6qigg4	231	4	at	at	IN
cord-002209-xs6qigg4	231	5	late	late	JJ
cord-002209-xs6qigg4	231	6	EAE	EAE	NNP
cord-002209-xs6qigg4	231	7	stages	stage	NNS
cord-002209-xs6qigg4	231	8	,	,	,
cord-002209-xs6qigg4	231	9	where	where	WRB
cord-002209-xs6qigg4	231	10	remyelination	remyelination	NN
cord-002209-xs6qigg4	231	11	was	be	VBD
cord-002209-xs6qigg4	231	12	observed	observe	VBN
cord-002209-xs6qigg4	231	13	,	,	,
cord-002209-xs6qigg4	231	14	leading	lead	VBG
cord-002209-xs6qigg4	231	15	to	to	IN
cord-002209-xs6qigg4	231	16	the	the	DT
cord-002209-xs6qigg4	231	17	suggestion	suggestion	NN
cord-002209-xs6qigg4	231	18	that	that	IN
cord-002209-xs6qigg4	231	19	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	231	20	protein	protein	NN
cord-002209-xs6qigg4	231	21	Cx43	Cx43	NNP
cord-002209-xs6qigg4	231	22	might	may	MD
cord-002209-xs6qigg4	231	23	play	play	VB
cord-002209-xs6qigg4	231	24	an	an	DT
cord-002209-xs6qigg4	231	25	important	important	JJ
cord-002209-xs6qigg4	231	26	role	role	NN
cord-002209-xs6qigg4	231	27	in	in	IN
cord-002209-xs6qigg4	231	28	recovery	recovery	NN
cord-002209-xs6qigg4	231	29	from	from	IN
cord-002209-xs6qigg4	231	30	neuroinflammation	neuroinflammation	NN
cord-002209-xs6qigg4	232	1	(	(	-LRB-
cord-002209-xs6qigg4	232	2	Markoullis	Markoullis	NNP
cord-002209-xs6qigg4	232	3	et	et	FW
cord-002209-xs6qigg4	232	4	al	al	NNP
cord-002209-xs6qigg4	232	5	.	.	NNP
cord-002209-xs6qigg4	232	6	,	,	,
cord-002209-xs6qigg4	232	7	2012	2012	CD
cord-002209-xs6qigg4	232	8	)	)	-RRB-
cord-002209-xs6qigg4	232	9	.	.	.
cord-002209-xs6qigg4	233	1	In	in	IN
cord-002209-xs6qigg4	233	2	the	the	DT
cord-002209-xs6qigg4	233	3	1980s	1980	NNS
cord-002209-xs6qigg4	233	4	advancements	advancement	NNS
cord-002209-xs6qigg4	233	5	were	be	VBD
cord-002209-xs6qigg4	233	6	made	make	VBN
cord-002209-xs6qigg4	233	7	on	on	IN
cord-002209-xs6qigg4	233	8	the	the	DT
cord-002209-xs6qigg4	233	9	ability	ability	NN
cord-002209-xs6qigg4	233	10	to	to	TO
cord-002209-xs6qigg4	233	11	grow	grow	VB
cord-002209-xs6qigg4	233	12	purified	purify	VBN
cord-002209-xs6qigg4	233	13	cultures	culture	NNS
cord-002209-xs6qigg4	233	14	of	of	IN
cord-002209-xs6qigg4	233	15	glial	glial	JJ
cord-002209-xs6qigg4	233	16	cells	cell	NNS
cord-002209-xs6qigg4	233	17	,	,	,
cord-002209-xs6qigg4	233	18	with	with	IN
cord-002209-xs6qigg4	233	19	Raff	Raff	NNP
cord-002209-xs6qigg4	233	20	and	and	CC
cord-002209-xs6qigg4	233	21	colleagues	colleague	NNS
cord-002209-xs6qigg4	233	22	in	in	IN
cord-002209-xs6qigg4	233	23	particular	particular	JJ
cord-002209-xs6qigg4	233	24	developing	develop	VBG
cord-002209-xs6qigg4	233	25	techniques	technique	NNS
cord-002209-xs6qigg4	233	26	to	to	TO
cord-002209-xs6qigg4	233	27	purify	purify	VB
cord-002209-xs6qigg4	233	28	OPCs	opc	NNS
cord-002209-xs6qigg4	233	29	from	from	IN
cord-002209-xs6qigg4	233	30	the	the	DT
cord-002209-xs6qigg4	233	31	optic	optic	JJ
cord-002209-xs6qigg4	233	32	nerve	nerve	NN
cord-002209-xs6qigg4	233	33	,	,	,
cord-002209-xs6qigg4	233	34	a	a	DT
cord-002209-xs6qigg4	233	35	tissue	tissue	NN
cord-002209-xs6qigg4	233	36	devoid	devoid	JJ
cord-002209-xs6qigg4	233	37	of	of	IN
cord-002209-xs6qigg4	233	38	neuronal	neuronal	JJ
cord-002209-xs6qigg4	233	39	cell	cell	NN
cord-002209-xs6qigg4	233	40	bodies	body	NNS
cord-002209-xs6qigg4	233	41	(	(	-LRB-
cord-002209-xs6qigg4	233	42	Raff	Raff	NNP
cord-002209-xs6qigg4	233	43	et	et	FW
cord-002209-xs6qigg4	233	44	al	al	NNP
cord-002209-xs6qigg4	233	45	.	.	NNP
cord-002209-xs6qigg4	233	46	,	,	,
cord-002209-xs6qigg4	233	47	1983	1983	CD
cord-002209-xs6qigg4	233	48	)	)	-RRB-
cord-002209-xs6qigg4	233	49	.	.	.
cord-002209-xs6qigg4	234	1	With	with	IN
cord-002209-xs6qigg4	234	2	the	the	DT
cord-002209-xs6qigg4	234	3	development	development	NN
cord-002209-xs6qigg4	234	4	of	of	IN
cord-002209-xs6qigg4	234	5	these	these	DT
cord-002209-xs6qigg4	234	6	culture	culture	NN
cord-002209-xs6qigg4	234	7	techniques	technique	NNS
cord-002209-xs6qigg4	234	8	it	-PRON-	PRP
cord-002209-xs6qigg4	234	9	was	be	VBD
cord-002209-xs6qigg4	234	10	shown	show	VBN
cord-002209-xs6qigg4	234	11	that	that	IN
cord-002209-xs6qigg4	234	12	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	234	13	play	play	VBP
cord-002209-xs6qigg4	234	14	important	important	JJ
cord-002209-xs6qigg4	234	15	roles	role	NNS
cord-002209-xs6qigg4	234	16	in	in	IN
cord-002209-xs6qigg4	234	17	OPC	opc	NN
cord-002209-xs6qigg4	234	18	differentiation	differentiation	NN
cord-002209-xs6qigg4	234	19	(	(	-LRB-
cord-002209-xs6qigg4	234	20	Noble	Noble	NNP
cord-002209-xs6qigg4	234	21	and	and	CC
cord-002209-xs6qigg4	234	22	Murray	Murray	NNP
cord-002209-xs6qigg4	234	23	,	,	,
cord-002209-xs6qigg4	234	24	1984	1984	CD
cord-002209-xs6qigg4	234	25	;	;	:
cord-002209-xs6qigg4	234	26	Noble	Noble	NNP
cord-002209-xs6qigg4	234	27	et	et	NNP
cord-002209-xs6qigg4	234	28	al	al	NNP
cord-002209-xs6qigg4	234	29	.	.	NNP
cord-002209-xs6qigg4	234	30	,	,	,
cord-002209-xs6qigg4	234	31	1988	1988	CD
cord-002209-xs6qigg4	234	32	;	;	:
cord-002209-xs6qigg4	234	33	Raff	Raff	NNP
cord-002209-xs6qigg4	234	34	et	et	NNP
cord-002209-xs6qigg4	234	35	al	al	NNP
cord-002209-xs6qigg4	234	36	.	.	NNP
cord-002209-xs6qigg4	234	37	,	,	,
cord-002209-xs6qigg4	234	38	1988	1988	CD
cord-002209-xs6qigg4	234	39	;	;	:
cord-002209-xs6qigg4	234	40	Noble	Noble	NNP
cord-002209-xs6qigg4	234	41	et	et	NNP
cord-002209-xs6qigg4	234	42	al	al	NNP
cord-002209-xs6qigg4	234	43	.	.	NNP
cord-002209-xs6qigg4	234	44	,	,	,
cord-002209-xs6qigg4	234	45	1989	1989	CD
cord-002209-xs6qigg4	234	46	)	)	-RRB-
cord-002209-xs6qigg4	235	1	and	and	CC
cord-002209-xs6qigg4	235	2	in	in	IN
cord-002209-xs6qigg4	235	3	the	the	DT
cord-002209-xs6qigg4	235	4	rate	rate	NN
cord-002209-xs6qigg4	235	5	of	of	IN
cord-002209-xs6qigg4	235	6	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	235	7	axonal	axonal	JJ
cord-002209-xs6qigg4	235	8	ensheathment	ensheathment	NN
cord-002209-xs6qigg4	235	9	(	(	-LRB-
cord-002209-xs6qigg4	235	10	Watkins	Watkins	NNP
cord-002209-xs6qigg4	235	11	et	et	NNP
cord-002209-xs6qigg4	235	12	al	al	NNP
cord-002209-xs6qigg4	235	13	.	.	NNP
cord-002209-xs6qigg4	235	14	,	,	,
cord-002209-xs6qigg4	235	15	2008	2008	CD
cord-002209-xs6qigg4	235	16	)	)	-RRB-
cord-002209-xs6qigg4	235	17	.	.	.
cord-002209-xs6qigg4	236	1	Further	further	RB
cord-002209-xs6qigg4	236	2	in	in	IN
cord-002209-xs6qigg4	236	3	vitro	vitro	FW
cord-002209-xs6qigg4	236	4	studies	study	NNS
cord-002209-xs6qigg4	236	5	,	,	,
cord-002209-xs6qigg4	236	6	where	where	WRB
cord-002209-xs6qigg4	236	7	conditioned	condition	VBN
cord-002209-xs6qigg4	236	8	medium	medium	NN
cord-002209-xs6qigg4	236	9	collected	collect	VBN
cord-002209-xs6qigg4	236	10	from	from	IN
cord-002209-xs6qigg4	236	11	primary	primary	JJ
cord-002209-xs6qigg4	236	12	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	236	13	monolayers	monolayer	NNS
cord-002209-xs6qigg4	236	14	was	be	VBD
cord-002209-xs6qigg4	236	15	incubated	incubate	VBN
cord-002209-xs6qigg4	236	16	with	with	IN
cord-002209-xs6qigg4	236	17	other	other	JJ
cord-002209-xs6qigg4	236	18	neural	neural	JJ
cord-002209-xs6qigg4	236	19	cells	cell	NNS
cord-002209-xs6qigg4	236	20	,	,	,
cord-002209-xs6qigg4	236	21	showed	show	VBD
cord-002209-xs6qigg4	236	22	enhanced	enhanced	JJ
cord-002209-xs6qigg4	236	23	neuronal	neuronal	JJ
cord-002209-xs6qigg4	236	24	survival	survival	NN
cord-002209-xs6qigg4	236	25	,	,	,
cord-002209-xs6qigg4	236	26	proliferation	proliferation	NN
cord-002209-xs6qigg4	236	27	of	of	IN
cord-002209-xs6qigg4	236	28	OPCs	opc	NNS
cord-002209-xs6qigg4	236	29	,	,	,
cord-002209-xs6qigg4	236	30	and	and	CC
cord-002209-xs6qigg4	236	31	protection	protection	NN
cord-002209-xs6qigg4	236	32	of	of	IN
cord-002209-xs6qigg4	236	33	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	236	34	from	from	IN
cord-002209-xs6qigg4	236	35	stress	stress	NN
cord-002209-xs6qigg4	236	36	(	(	-LRB-
cord-002209-xs6qigg4	236	37	Noble	Noble	NNP
cord-002209-xs6qigg4	236	38	and	and	CC
cord-002209-xs6qigg4	236	39	Murray	Murray	NNP
cord-002209-xs6qigg4	236	40	,	,	,
cord-002209-xs6qigg4	236	41	1984	1984	CD
cord-002209-xs6qigg4	236	42	;	;	:
cord-002209-xs6qigg4	236	43	Yoshida	Yoshida	NNP
cord-002209-xs6qigg4	236	44	et	et	NNP
cord-002209-xs6qigg4	236	45	al	al	NNP
cord-002209-xs6qigg4	236	46	.	.	NNP
cord-002209-xs6qigg4	236	47	,	,	,
cord-002209-xs6qigg4	236	48	1995	1995	CD
cord-002209-xs6qigg4	236	49	;	;	:
cord-002209-xs6qigg4	236	50	Yamamuro	Yamamuro	NNP
cord-002209-xs6qigg4	236	51	et	et	FW
cord-002209-xs6qigg4	236	52	al	al	NNP
cord-002209-xs6qigg4	236	53	.	.	NNP
cord-002209-xs6qigg4	236	54	,	,	,
cord-002209-xs6qigg4	236	55	2003	2003	CD
cord-002209-xs6qigg4	236	56	;	;	:
cord-002209-xs6qigg4	237	1	Zhu	Zhu	NNP
cord-002209-xs6qigg4	237	2	et	et	FW
cord-002209-xs6qigg4	237	3	al	al	NNP
cord-002209-xs6qigg4	237	4	.	.	NNP
cord-002209-xs6qigg4	237	5	,	,	,
cord-002209-xs6qigg4	237	6	2006	2006	CD
cord-002209-xs6qigg4	237	7	;	;	:
cord-002209-xs6qigg4	237	8	Arai	Arai	NNP
cord-002209-xs6qigg4	237	9	and	and	CC
cord-002209-xs6qigg4	237	10	Lo	Lo	NNP
cord-002209-xs6qigg4	237	11	,	,	,
cord-002209-xs6qigg4	237	12	2010	2010	CD
cord-002209-xs6qigg4	237	13	)	)	-RRB-
cord-002209-xs6qigg4	237	14	.	.	.
cord-002209-xs6qigg4	238	1	It	-PRON-	PRP
cord-002209-xs6qigg4	238	2	is	be	VBZ
cord-002209-xs6qigg4	238	3	likely	likely	JJ
cord-002209-xs6qigg4	238	4	that	that	IN
cord-002209-xs6qigg4	238	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	238	6	support	support	VBP
cord-002209-xs6qigg4	238	7	OPC	OPC	NNP
cord-002209-xs6qigg4	238	8	survival	survival	NN
cord-002209-xs6qigg4	238	9	and	and	CC
cord-002209-xs6qigg4	238	10	proliferation	proliferation	NN
cord-002209-xs6qigg4	238	11	by	by	IN
cord-002209-xs6qigg4	238	12	providing	provide	VBG
cord-002209-xs6qigg4	238	13	soluble	soluble	JJ
cord-002209-xs6qigg4	238	14	factors	factor	NNS
cord-002209-xs6qigg4	238	15	such	such	JJ
cord-002209-xs6qigg4	238	16	as	as	IN
cord-002209-xs6qigg4	238	17	platelet	platelet	NN
cord-002209-xs6qigg4	238	18	derived	derive	VBN
cord-002209-xs6qigg4	238	19	growth	growth	NN
cord-002209-xs6qigg4	238	20	factor	factor	NN
cord-002209-xs6qigg4	238	21	(	(	-LRB-
cord-002209-xs6qigg4	238	22	PDGF	PDGF	NNP
cord-002209-xs6qigg4	238	23	)	)	-RRB-
cord-002209-xs6qigg4	238	24	and	and	CC
cord-002209-xs6qigg4	238	25	FGF-2	FGF-2	NNP
cord-002209-xs6qigg4	238	26	(	(	-LRB-
cord-002209-xs6qigg4	238	27	Bögler	Bögler	NNP
cord-002209-xs6qigg4	238	28	et	et	NNP
cord-002209-xs6qigg4	238	29	al	al	NNP
cord-002209-xs6qigg4	238	30	.	.	NNP
cord-002209-xs6qigg4	238	31	,	,	,
cord-002209-xs6qigg4	238	32	1990	1990	CD
cord-002209-xs6qigg4	238	33	;	;	:
cord-002209-xs6qigg4	238	34	Ferrara	Ferrara	NNP
cord-002209-xs6qigg4	238	35	et	et	NNP
cord-002209-xs6qigg4	238	36	al	al	NNP
cord-002209-xs6qigg4	238	37	.	.	NNP
cord-002209-xs6qigg4	238	38	,	,	,
cord-002209-xs6qigg4	238	39	1988	1988	CD
cord-002209-xs6qigg4	238	40	;	;	:
cord-002209-xs6qigg4	238	41	Pringle	Pringle	NNP
cord-002209-xs6qigg4	238	42	et	et	NNP
cord-002209-xs6qigg4	238	43	al	al	NNP
cord-002209-xs6qigg4	238	44	.	.	NNP
cord-002209-xs6qigg4	238	45	,	,	,
cord-002209-xs6qigg4	238	46	1989	1989	CD
cord-002209-xs6qigg4	238	47	)	)	-RRB-
cord-002209-xs6qigg4	238	48	.	.	.
cord-002209-xs6qigg4	239	1	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	239	2	are	be	VBP
cord-002209-xs6qigg4	239	3	important	important	JJ
cord-002209-xs6qigg4	239	4	providers	provider	NNS
cord-002209-xs6qigg4	239	5	of	of	IN
cord-002209-xs6qigg4	239	6	secreted	secrete	VBN
cord-002209-xs6qigg4	239	7	growth	growth	NN
cord-002209-xs6qigg4	239	8	factors	factor	NNS
cord-002209-xs6qigg4	239	9	,	,	,
cord-002209-xs6qigg4	239	10	for	for	IN
cord-002209-xs6qigg4	239	11	both	both	DT
cord-002209-xs6qigg4	239	12	neuronal	neuronal	JJ
cord-002209-xs6qigg4	239	13	and	and	CC
cord-002209-xs6qigg4	239	14	glial	glial	JJ
cord-002209-xs6qigg4	239	15	proliferation	proliferation	NN
cord-002209-xs6qigg4	239	16	and	and	CC
cord-002209-xs6qigg4	239	17	survival	survival	NN
cord-002209-xs6qigg4	239	18	.	.	.
cord-002209-xs6qigg4	240	1	For	for	IN
cord-002209-xs6qigg4	240	2	example	example	NN
cord-002209-xs6qigg4	240	3	,	,	,
cord-002209-xs6qigg4	240	4	CNTF	CNTF	NNP
cord-002209-xs6qigg4	240	5	,	,	,
cord-002209-xs6qigg4	240	6	although	although	IN
cord-002209-xs6qigg4	240	7	shown	show	VBN
cord-002209-xs6qigg4	240	8	to	to	TO
cord-002209-xs6qigg4	240	9	be	be	VB
cord-002209-xs6qigg4	240	10	important	important	JJ
cord-002209-xs6qigg4	240	11	in	in	IN
cord-002209-xs6qigg4	240	12	the	the	DT
cord-002209-xs6qigg4	240	13	activation	activation	NN
cord-002209-xs6qigg4	240	14	of	of	IN
cord-002209-xs6qigg4	240	15	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	240	16	,	,	,
cord-002209-xs6qigg4	240	17	is	be	VBZ
cord-002209-xs6qigg4	240	18	constitutively	constitutively	RB
cord-002209-xs6qigg4	240	19	expressed	express	VBN
cord-002209-xs6qigg4	240	20	by	by	IN
cord-002209-xs6qigg4	240	21	white	white	JJ
cord-002209-xs6qigg4	240	22	matter	matter	NN
cord-002209-xs6qigg4	240	23	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	240	24	,	,	,
cord-002209-xs6qigg4	240	25	and	and	CC
cord-002209-xs6qigg4	240	26	is	be	VBZ
cord-002209-xs6qigg4	240	27	a	a	DT
cord-002209-xs6qigg4	240	28	key	key	JJ
cord-002209-xs6qigg4	240	29	player	player	NN
cord-002209-xs6qigg4	240	30	in	in	IN
cord-002209-xs6qigg4	240	31	OPC	OPC	NNP
cord-002209-xs6qigg4	240	32	survival	survival	NN
cord-002209-xs6qigg4	240	33	and	and	CC
cord-002209-xs6qigg4	240	34	maturation	maturation	NN
cord-002209-xs6qigg4	240	35	in	in	IN
cord-002209-xs6qigg4	240	36	vitro	vitro	FW
cord-002209-xs6qigg4	240	37	and	and	CC
cord-002209-xs6qigg4	240	38	in	in	IN
cord-002209-xs6qigg4	240	39	vivo	vivo	NNP
cord-002209-xs6qigg4	240	40	as	as	IN
cord-002209-xs6qigg4	240	41	discussed	discuss	VBN
cord-002209-xs6qigg4	240	42	earlier	early	RBR
cord-002209-xs6qigg4	240	43	(	(	-LRB-
cord-002209-xs6qigg4	240	44	Stöckli	Stöckli	NNP
cord-002209-xs6qigg4	240	45	et	et	FW
cord-002209-xs6qigg4	240	46	al	al	NNP
cord-002209-xs6qigg4	240	47	.	.	NNP
cord-002209-xs6qigg4	240	48	,	,	,
cord-002209-xs6qigg4	240	49	1991	1991	CD
cord-002209-xs6qigg4	240	50	;	;	:
cord-002209-xs6qigg4	240	51	Dallner	Dallner	NNP
cord-002209-xs6qigg4	240	52	et	et	NNP
cord-002209-xs6qigg4	240	53	al	al	NNP
cord-002209-xs6qigg4	240	54	.	.	NNP
cord-002209-xs6qigg4	240	55	,	,	,
cord-002209-xs6qigg4	240	56	2002	2002	CD
cord-002209-xs6qigg4	240	57	;	;	:
cord-002209-xs6qigg4	240	58	Stankoff	Stankoff	NNP
cord-002209-xs6qigg4	240	59	et	et	NNP
cord-002209-xs6qigg4	240	60	al	al	NNP
cord-002209-xs6qigg4	240	61	.	.	NNP
cord-002209-xs6qigg4	240	62	,	,	,
cord-002209-xs6qigg4	240	63	2002	2002	CD
cord-002209-xs6qigg4	240	64	;	;	:
cord-002209-xs6qigg4	240	65	Cao	Cao	NNP
cord-002209-xs6qigg4	240	66	et	et	NNP
cord-002209-xs6qigg4	240	67	al	al	NNP
cord-002209-xs6qigg4	240	68	.	.	NNP
cord-002209-xs6qigg4	240	69	,	,	,
cord-002209-xs6qigg4	240	70	2010	2010	CD
cord-002209-xs6qigg4	240	71	)	)	-RRB-
cord-002209-xs6qigg4	240	72	.	.	.
cord-002209-xs6qigg4	241	1	CNTF	CNTF	NNP
cord-002209-xs6qigg4	241	2	has	have	VBZ
cord-002209-xs6qigg4	241	3	also	also	RB
cord-002209-xs6qigg4	241	4	been	be	VBN
cord-002209-xs6qigg4	241	5	reported	report	VBN
cord-002209-xs6qigg4	241	6	to	to	TO
cord-002209-xs6qigg4	241	7	enhance	enhance	VB
cord-002209-xs6qigg4	241	8	the	the	DT
cord-002209-xs6qigg4	241	9	migration	migration	NN
cord-002209-xs6qigg4	241	10	of	of	IN
cord-002209-xs6qigg4	241	11	subventricular	subventricular	NNP
cord-002209-xs6qigg4	241	12	zone	zone	NNP
cord-002209-xs6qigg4	241	13	-	-	HYPH
cord-002209-xs6qigg4	241	14	derived	derive	VBN
cord-002209-xs6qigg4	241	15	progenitors	progenitor	NNS
cord-002209-xs6qigg4	241	16	(	(	-LRB-
cord-002209-xs6qigg4	241	17	Vernerey	Vernerey	NNP
cord-002209-xs6qigg4	241	18	et	et	NNP
cord-002209-xs6qigg4	241	19	al	al	NNP
cord-002209-xs6qigg4	241	20	.	.	NNP
cord-002209-xs6qigg4	241	21	,	,	,
cord-002209-xs6qigg4	241	22	2013	2013	CD
cord-002209-xs6qigg4	241	23	)	)	-RRB-
cord-002209-xs6qigg4	241	24	,	,	,
cord-002209-xs6qigg4	241	25	protect	protect	VB
cord-002209-xs6qigg4	241	26	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	241	27	from	from	IN
cord-002209-xs6qigg4	241	28	apoptosis	apoptosis	NN
cord-002209-xs6qigg4	241	29	,	,	,
cord-002209-xs6qigg4	241	30	and	and	CC
cord-002209-xs6qigg4	241	31	decrease	decrease	VB
cord-002209-xs6qigg4	241	32	myelin	myelin	JJ
cord-002209-xs6qigg4	241	33	destruction	destruction	NN
cord-002209-xs6qigg4	241	34	in	in	IN
cord-002209-xs6qigg4	241	35	demyelinating	demyelinating	JJ
cord-002209-xs6qigg4	241	36	pathological	pathological	JJ
cord-002209-xs6qigg4	241	37	conditions	condition	NNS
cord-002209-xs6qigg4	241	38	(	(	-LRB-
cord-002209-xs6qigg4	241	39	Linker	Linker	NNP
cord-002209-xs6qigg4	241	40	et	et	FW
cord-002209-xs6qigg4	241	41	al	al	NNP
cord-002209-xs6qigg4	241	42	.	.	NNP
cord-002209-xs6qigg4	241	43	,	,	,
cord-002209-xs6qigg4	241	44	2002	2002	CD
cord-002209-xs6qigg4	241	45	)	)	-RRB-
cord-002209-xs6qigg4	241	46	.	.	.
cord-002209-xs6qigg4	242	1	In	in	IN
cord-002209-xs6qigg4	242	2	studies	study	NNS
cord-002209-xs6qigg4	242	3	when	when	WRB
cord-002209-xs6qigg4	242	4	CNTF	CNTF	NNP
cord-002209-xs6qigg4	242	5	was	be	VBD
cord-002209-xs6qigg4	242	6	injected	inject	VBN
cord-002209-xs6qigg4	242	7	subcutaneously	subcutaneously	RB
cord-002209-xs6qigg4	242	8	at	at	IN
cord-002209-xs6qigg4	242	9	the	the	DT
cord-002209-xs6qigg4	242	10	remyelination	remyelination	NN
cord-002209-xs6qigg4	242	11	phase	phase	NN
cord-002209-xs6qigg4	242	12	of	of	IN
cord-002209-xs6qigg4	242	13	cuprizoneinduced	cuprizoneinduced	JJ
cord-002209-xs6qigg4	242	14	demyelination	demyelination	NN
cord-002209-xs6qigg4	242	15	,	,	,
cord-002209-xs6qigg4	242	16	an	an	DT
cord-002209-xs6qigg4	242	17	increase	increase	NN
cord-002209-xs6qigg4	242	18	was	be	VBD
cord-002209-xs6qigg4	242	19	seen	see	VBN
cord-002209-xs6qigg4	242	20	in	in	IN
cord-002209-xs6qigg4	242	21	myelin	myelin	NN
cord-002209-xs6qigg4	242	22	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	242	23	glycoprotein	glycoprotein	NN
cord-002209-xs6qigg4	242	24	(	(	-LRB-
cord-002209-xs6qigg4	242	25	MOG	MOG	NNP
cord-002209-xs6qigg4	242	26	)	)	-RRB-
cord-002209-xs6qigg4	242	27	expression	expression	NN
cord-002209-xs6qigg4	242	28	in	in	IN
cord-002209-xs6qigg4	242	29	the	the	DT
cord-002209-xs6qigg4	242	30	cerebral	cerebral	JJ
cord-002209-xs6qigg4	242	31	cortex	cortex	NN
cord-002209-xs6qigg4	243	1	(	(	-LRB-
cord-002209-xs6qigg4	243	2	Salehi	Salehi	NNP
cord-002209-xs6qigg4	243	3	et	et	FW
cord-002209-xs6qigg4	243	4	al	al	NNP
cord-002209-xs6qigg4	243	5	.	.	NNP
cord-002209-xs6qigg4	243	6	,	,	,
cord-002209-xs6qigg4	243	7	2013	2013	CD
cord-002209-xs6qigg4	243	8	)	)	-RRB-
cord-002209-xs6qigg4	243	9	.	.	.
cord-002209-xs6qigg4	244	1	Moreover	moreover	RB
cord-002209-xs6qigg4	244	2	,	,	,
cord-002209-xs6qigg4	244	3	intraperitoneal	intraperitoneal	JJ
cord-002209-xs6qigg4	244	4	injections	injection	NNS
cord-002209-xs6qigg4	244	5	of	of	IN
cord-002209-xs6qigg4	244	6	CNTF	CNTF	NNP
cord-002209-xs6qigg4	244	7	and	and	CC
cord-002209-xs6qigg4	244	8	intravenously	intravenously	RB
cord-002209-xs6qigg4	244	9	transplanted	transplant	VBD
cord-002209-xs6qigg4	244	10	mesenchymal	mesenchymal	JJ
cord-002209-xs6qigg4	244	11	stem	stem	NN
cord-002209-xs6qigg4	244	12	cells	cell	NNS
cord-002209-xs6qigg4	244	13	that	that	WDT
cord-002209-xs6qigg4	244	14	overexpress	overexpress	VBP
cord-002209-xs6qigg4	244	15	CNTF	CNTF	NNP
cord-002209-xs6qigg4	244	16	resulted	result	VBD
cord-002209-xs6qigg4	244	17	in	in	IN
cord-002209-xs6qigg4	244	18	a	a	DT
cord-002209-xs6qigg4	244	19	reduced	reduce	VBN
cord-002209-xs6qigg4	244	20	loss	loss	NN
cord-002209-xs6qigg4	244	21	of	of	IN
cord-002209-xs6qigg4	244	22	neurons	neuron	NNS
cord-002209-xs6qigg4	244	23	and	and	CC
cord-002209-xs6qigg4	244	24	disease	disease	NN
cord-002209-xs6qigg4	244	25	severity	severity	NN
cord-002209-xs6qigg4	244	26	,	,	,
cord-002209-xs6qigg4	244	27	and	and	CC
cord-002209-xs6qigg4	244	28	increased	increase	VBN
cord-002209-xs6qigg4	244	29	neuronal	neuronal	JJ
cord-002209-xs6qigg4	244	30	functional	functional	JJ
cord-002209-xs6qigg4	244	31	recovery	recovery	NN
cord-002209-xs6qigg4	244	32	in	in	IN
cord-002209-xs6qigg4	244	33	EAE	EAE	NNP
cord-002209-xs6qigg4	244	34	mice	mouse	NNS
cord-002209-xs6qigg4	245	1	(	(	-LRB-
cord-002209-xs6qigg4	245	2	Kuhlmann	Kuhlmann	NNP
cord-002209-xs6qigg4	245	3	et	et	NNP
cord-002209-xs6qigg4	245	4	al	al	NNP
cord-002209-xs6qigg4	245	5	.	.	NNP
cord-002209-xs6qigg4	245	6	,	,	,
cord-002209-xs6qigg4	245	7	2006	2006	CD
cord-002209-xs6qigg4	245	8	;	;	:
cord-002209-xs6qigg4	245	9	Lu	Lu	NNP
cord-002209-xs6qigg4	245	10	et	et	FW
cord-002209-xs6qigg4	245	11	al	al	NNP
cord-002209-xs6qigg4	245	12	.	.	NNP
cord-002209-xs6qigg4	245	13	,	,	,
cord-002209-xs6qigg4	245	14	2009	2009	CD
cord-002209-xs6qigg4	245	15	)	)	-RRB-
cord-002209-xs6qigg4	245	16	.	.	.
cord-002209-xs6qigg4	246	1	However	however	RB
cord-002209-xs6qigg4	246	2	,	,	,
cord-002209-xs6qigg4	246	3	in	in	IN
cord-002209-xs6qigg4	246	4	these	these	DT
cord-002209-xs6qigg4	246	5	experiments	experiment	NNS
cord-002209-xs6qigg4	246	6	it	-PRON-	PRP
cord-002209-xs6qigg4	246	7	is	be	VBZ
cord-002209-xs6qigg4	246	8	difficult	difficult	JJ
cord-002209-xs6qigg4	246	9	to	to	TO
cord-002209-xs6qigg4	246	10	see	see	VB
cord-002209-xs6qigg4	246	11	if	if	IN
cord-002209-xs6qigg4	246	12	the	the	DT
cord-002209-xs6qigg4	246	13	effect	effect	NN
cord-002209-xs6qigg4	246	14	is	be	VBZ
cord-002209-xs6qigg4	246	15	on	on	IN
cord-002209-xs6qigg4	246	16	the	the	DT
cord-002209-xs6qigg4	246	17	activation	activation	NN
cord-002209-xs6qigg4	246	18	status	status	NN
cord-002209-xs6qigg4	246	19	of	of	IN
cord-002209-xs6qigg4	246	20	the	the	DT
cord-002209-xs6qigg4	246	21	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	246	22	as	as	IN
cord-002209-xs6qigg4	246	23	discussed	discuss	VBN
cord-002209-xs6qigg4	246	24	above	above	RB
cord-002209-xs6qigg4	246	25	,	,	,
cord-002209-xs6qigg4	246	26	or	or	CC
cord-002209-xs6qigg4	246	27	the	the	DT
cord-002209-xs6qigg4	246	28	direct	direct	JJ
cord-002209-xs6qigg4	246	29	effect	effect	NN
cord-002209-xs6qigg4	246	30	on	on	IN
cord-002209-xs6qigg4	246	31	the	the	DT
cord-002209-xs6qigg4	246	32	OPC	OPC	NNP
cord-002209-xs6qigg4	246	33	.	.	.
cord-002209-xs6qigg4	247	1	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	247	2	have	have	VBP
cord-002209-xs6qigg4	247	3	also	also	RB
cord-002209-xs6qigg4	247	4	been	be	VBN
cord-002209-xs6qigg4	247	5	shown	show	VBN
cord-002209-xs6qigg4	247	6	to	to	TO
cord-002209-xs6qigg4	247	7	exhibit	exhibit	VB
cord-002209-xs6qigg4	247	8	a	a	DT
cord-002209-xs6qigg4	247	9	crucial	crucial	JJ
cord-002209-xs6qigg4	247	10	role	role	NN
cord-002209-xs6qigg4	247	11	in	in	IN
cord-002209-xs6qigg4	247	12	OPC	OPC	NNP
cord-002209-xs6qigg4	247	13	remyelination	remyelination	NN
cord-002209-xs6qigg4	247	14	via	via	IN
cord-002209-xs6qigg4	247	15	their	-PRON-	PRP$
cord-002209-xs6qigg4	247	16	iron	iron	NN
cord-002209-xs6qigg4	247	17	exporter	exporter	NN
cord-002209-xs6qigg4	247	18	ferroportin	ferroportin	NN
cord-002209-xs6qigg4	247	19	(	(	-LRB-
cord-002209-xs6qigg4	247	20	Fpn	Fpn	NNP
cord-002209-xs6qigg4	247	21	)	)	-RRB-
cord-002209-xs6qigg4	247	22	in	in	IN
cord-002209-xs6qigg4	247	23	mice	mouse	NNS
cord-002209-xs6qigg4	247	24	,	,	,
cord-002209-xs6qigg4	247	25	where	where	WRB
cord-002209-xs6qigg4	247	26	focal	focal	JJ
cord-002209-xs6qigg4	247	27	demyelination	demyelination	NN
cord-002209-xs6qigg4	247	28	was	be	VBD
cord-002209-xs6qigg4	247	29	induced	induce	VBN
cord-002209-xs6qigg4	247	30	by	by	IN
cord-002209-xs6qigg4	247	31	the	the	DT
cord-002209-xs6qigg4	247	32	injection	injection	NN
cord-002209-xs6qigg4	247	33	of	of	IN
cord-002209-xs6qigg4	247	34	lysophosphatidylcholine	lysophosphatidylcholine	NNP
cord-002209-xs6qigg4	247	35	(	(	-LRB-
cord-002209-xs6qigg4	247	36	LPC	LPC	NNP
cord-002209-xs6qigg4	247	37	)	)	-RRB-
cord-002209-xs6qigg4	247	38	into	into	IN
cord-002209-xs6qigg4	247	39	their	-PRON-	PRP$
cord-002209-xs6qigg4	247	40	spinal	spinal	JJ
cord-002209-xs6qigg4	247	41	cords	cord	NNS
cord-002209-xs6qigg4	247	42	(	(	-LRB-
cord-002209-xs6qigg4	247	43	Schulz	Schulz	NNP
cord-002209-xs6qigg4	247	44	et	et	NNP
cord-002209-xs6qigg4	247	45	al	al	NNP
cord-002209-xs6qigg4	247	46	.	.	NNP
cord-002209-xs6qigg4	247	47	,	,	,
cord-002209-xs6qigg4	247	48	2012	2012	CD
cord-002209-xs6qigg4	247	49	)	)	-RRB-
cord-002209-xs6qigg4	247	50	.	.	.
cord-002209-xs6qigg4	248	1	In	in	IN
cord-002209-xs6qigg4	248	2	these	these	DT
cord-002209-xs6qigg4	248	3	astrocyte	astrocyte	NN
cord-002209-xs6qigg4	248	4	-	-	HYPH
cord-002209-xs6qigg4	248	5	specific	specific	JJ
cord-002209-xs6qigg4	248	6	Fpn	Fpn	NNP
cord-002209-xs6qigg4	248	7	KO	KO	NNP
cord-002209-xs6qigg4	248	8	mice	mouse	NNS
cord-002209-xs6qigg4	248	9	,	,	,
cord-002209-xs6qigg4	248	10	fewer	few	JJR
cord-002209-xs6qigg4	248	11	remyelinating	remyelinate	VBG
cord-002209-xs6qigg4	248	12	axons	axon	NNS
cord-002209-xs6qigg4	248	13	and	and	CC
cord-002209-xs6qigg4	248	14	a	a	DT
cord-002209-xs6qigg4	248	15	reduction	reduction	NN
cord-002209-xs6qigg4	248	16	in	in	IN
cord-002209-xs6qigg4	248	17	OPC	opc	NN
cord-002209-xs6qigg4	248	18	proliferation	proliferation	NN
cord-002209-xs6qigg4	248	19	were	be	VBD
cord-002209-xs6qigg4	248	20	observed	observe	VBN
cord-002209-xs6qigg4	248	21	following	follow	VBG
cord-002209-xs6qigg4	248	22	LPC	LPC	NNP
cord-002209-xs6qigg4	248	23	-	-	HYPH
cord-002209-xs6qigg4	248	24	induced	induce	VBN
cord-002209-xs6qigg4	248	25	demyelination	demyelination	NN
cord-002209-xs6qigg4	248	26	compared	compare	VBN
cord-002209-xs6qigg4	248	27	to	to	TO
cord-002209-xs6qigg4	248	28	control	control	NN
cord-002209-xs6qigg4	248	29	animals	animal	NNS
cord-002209-xs6qigg4	248	30	.	.	.
cord-002209-xs6qigg4	249	1	This	this	DT
cord-002209-xs6qigg4	249	2	could	could	MD
cord-002209-xs6qigg4	249	3	either	either	CC
cord-002209-xs6qigg4	249	4	be	be	VB
cord-002209-xs6qigg4	249	5	due	due	JJ
cord-002209-xs6qigg4	249	6	to	to	IN
cord-002209-xs6qigg4	249	7	direct	direct	JJ
cord-002209-xs6qigg4	249	8	effects	effect	NNS
cord-002209-xs6qigg4	249	9	on	on	IN
cord-002209-xs6qigg4	249	10	OPCs	opc	NNS
cord-002209-xs6qigg4	249	11	through	through	IN
cord-002209-xs6qigg4	249	12	limited	limited	JJ
cord-002209-xs6qigg4	249	13	iron	iron	NN
cord-002209-xs6qigg4	249	14	supply	supply	NN
cord-002209-xs6qigg4	249	15	or	or	CC
cord-002209-xs6qigg4	249	16	indirect	indirect	JJ
cord-002209-xs6qigg4	249	17	effects	effect	NNS
cord-002209-xs6qigg4	249	18	via	via	IN
cord-002209-xs6qigg4	249	19	iron	iron	NN
cord-002209-xs6qigg4	249	20	-	-	HYPH
cord-002209-xs6qigg4	249	21	deficient	deficient	JJ
cord-002209-xs6qigg4	249	22	microglia	microglia	NN
cord-002209-xs6qigg4	249	23	,	,	,
cord-002209-xs6qigg4	249	24	which	which	WDT
cord-002209-xs6qigg4	249	25	expressed	express	VBD
cord-002209-xs6qigg4	249	26	significantly	significantly	RB
cord-002209-xs6qigg4	249	27	lower	low	JJR
cord-002209-xs6qigg4	249	28	levels	level	NNS
cord-002209-xs6qigg4	249	29	of	of	IN
cord-002209-xs6qigg4	249	30	TNF	TNF	NNP
cord-002209-xs6qigg4	249	31	-	-	HYPH
cord-002209-xs6qigg4	249	32	α	α	NNP
cord-002209-xs6qigg4	249	33	and	and	CC
cord-002209-xs6qigg4	249	34	IL-1β	il-1β	NN
cord-002209-xs6qigg4	249	35	when	when	WRB
cord-002209-xs6qigg4	249	36	stimulated	stimulate	VBN
cord-002209-xs6qigg4	249	37	by	by	IN
cord-002209-xs6qigg4	249	38	LPS	lp	NNS
cord-002209-xs6qigg4	249	39	compared	compare	VBN
cord-002209-xs6qigg4	249	40	to	to	TO
cord-002209-xs6qigg4	249	41	control	control	NN
cord-002209-xs6qigg4	249	42	microglia	microglia	NNS
cord-002209-xs6qigg4	249	43	(	(	-LRB-
cord-002209-xs6qigg4	249	44	Schulz	Schulz	NNP
cord-002209-xs6qigg4	249	45	et	et	NNP
cord-002209-xs6qigg4	249	46	al	al	NNP
cord-002209-xs6qigg4	249	47	.	.	NNP
cord-002209-xs6qigg4	249	48	,	,	,
cord-002209-xs6qigg4	249	49	2012	2012	CD
cord-002209-xs6qigg4	249	50	)	)	-RRB-
cord-002209-xs6qigg4	249	51	.	.	.
cord-002209-xs6qigg4	250	1	Because	because	IN
cord-002209-xs6qigg4	250	2	the	the	DT
cord-002209-xs6qigg4	250	3	expression	expression	NN
cord-002209-xs6qigg4	250	4	of	of	IN
cord-002209-xs6qigg4	250	5	FGF-2	FGF-2	NNP
cord-002209-xs6qigg4	250	6	and	and	CC
cord-002209-xs6qigg4	250	7	insulin	insulin	NN
cord-002209-xs6qigg4	250	8	-	-	HYPH
cord-002209-xs6qigg4	250	9	like	like	JJ
cord-002209-xs6qigg4	250	10	growth	growth	NN
cord-002209-xs6qigg4	250	11	factor-1	factor-1	NNP
cord-002209-xs6qigg4	250	12	(	(	-LRB-
cord-002209-xs6qigg4	250	13	IGF-1	IGF-1	NNP
cord-002209-xs6qigg4	250	14	)	)	-RRB-
cord-002209-xs6qigg4	250	15	was	be	VBD
cord-002209-xs6qigg4	250	16	significantly	significantly	RB
cord-002209-xs6qigg4	250	17	upregulated	upregulate	VBN
cord-002209-xs6qigg4	250	18	by	by	IN
cord-002209-xs6qigg4	250	19	IL-1β	IL-1β	NNP
cord-002209-xs6qigg4	250	20	and	and	CC
cord-002209-xs6qigg4	250	21	TNF	TNF	NNP
cord-002209-xs6qigg4	250	22	-	-	HYPH
cord-002209-xs6qigg4	250	23	α	α	NNP
cord-002209-xs6qigg4	250	24	,	,	,
cord-002209-xs6qigg4	250	25	respectively	respectively	RB
cord-002209-xs6qigg4	250	26	,	,	,
cord-002209-xs6qigg4	250	27	and	and	CC
cord-002209-xs6qigg4	250	28	the	the	DT
cord-002209-xs6qigg4	250	29	expression	expression	NN
cord-002209-xs6qigg4	250	30	of	of	IN
cord-002209-xs6qigg4	250	31	transforming	transform	VBG
cord-002209-xs6qigg4	250	32	growth	growth	NN
cord-002209-xs6qigg4	250	33	factor	factor	NN
cord-002209-xs6qigg4	250	34	beta	beta	NN
cord-002209-xs6qigg4	250	35	(	(	-LRB-
cord-002209-xs6qigg4	250	36	TGF	TGF	NNP
cord-002209-xs6qigg4	250	37	-	-	HYPH
cord-002209-xs6qigg4	250	38	β	β	NNP
cord-002209-xs6qigg4	250	39	)	)	-RRB-
cord-002209-xs6qigg4	250	40	was	be	VBD
cord-002209-xs6qigg4	250	41	stimulated	stimulate	VBN
cord-002209-xs6qigg4	250	42	by	by	IN
cord-002209-xs6qigg4	250	43	IL-1β	IL-1β	NNS
cord-002209-xs6qigg4	250	44	in	in	IN
cord-002209-xs6qigg4	250	45	purified	purify	VBN
cord-002209-xs6qigg4	250	46	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	250	47	cultures	culture	NNS
cord-002209-xs6qigg4	250	48	,	,	,
cord-002209-xs6qigg4	250	49	it	-PRON-	PRP
cord-002209-xs6qigg4	250	50	has	have	VBZ
cord-002209-xs6qigg4	250	51	been	be	VBN
cord-002209-xs6qigg4	250	52	suggested	suggest	VBN
cord-002209-xs6qigg4	250	53	that	that	IN
cord-002209-xs6qigg4	250	54	iron	iron	NN
cord-002209-xs6qigg4	250	55	-	-	HYPH
cord-002209-xs6qigg4	250	56	deprivation	deprivation	NN
cord-002209-xs6qigg4	250	57	in	in	IN
cord-002209-xs6qigg4	250	58	the	the	DT
cord-002209-xs6qigg4	250	59	milieu	milieu	NN
cord-002209-xs6qigg4	250	60	would	would	MD
cord-002209-xs6qigg4	250	61	lower	lower	VB
cord-002209-xs6qigg4	250	62	the	the	DT
cord-002209-xs6qigg4	250	63	expression	expression	NN
cord-002209-xs6qigg4	250	64	of	of	IN
cord-002209-xs6qigg4	250	65	IL-1β	IL-1β	NNP
cord-002209-xs6qigg4	250	66	and	and	CC
cord-002209-xs6qigg4	250	67	TNF	TNF	NNP
cord-002209-xs6qigg4	250	68	-	-	HYPH
cord-002209-xs6qigg4	250	69	α	α	NNP
cord-002209-xs6qigg4	250	70	in	in	IN
cord-002209-xs6qigg4	250	71	microglia	microglia	NN
cord-002209-xs6qigg4	250	72	and	and	CC
cord-002209-xs6qigg4	250	73	thus	thus	RB
cord-002209-xs6qigg4	250	74	lead	lead	VB
cord-002209-xs6qigg4	250	75	to	to	IN
cord-002209-xs6qigg4	250	76	reduced	reduce	VBN
cord-002209-xs6qigg4	250	77	growth	growth	NN
cord-002209-xs6qigg4	250	78	factor	factor	NN
cord-002209-xs6qigg4	250	79	expression	expression	NN
cord-002209-xs6qigg4	250	80	in	in	IN
cord-002209-xs6qigg4	250	81	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	250	82	,	,	,
cord-002209-xs6qigg4	250	83	which	which	WDT
cord-002209-xs6qigg4	250	84	would	would	MD
cord-002209-xs6qigg4	250	85	in	in	IN
cord-002209-xs6qigg4	250	86	turn	turn	VB
cord-002209-xs6qigg4	250	87	render	render	VB
cord-002209-xs6qigg4	250	88	OPC	opc	NN
cord-002209-xs6qigg4	250	89	proliferation	proliferation	NN
cord-002209-xs6qigg4	250	90	and	and	CC
cord-002209-xs6qigg4	250	91	possibly	possibly	RB
cord-002209-xs6qigg4	250	92	differentiation	differentiation	NN
cord-002209-xs6qigg4	251	1	(	(	-LRB-
cord-002209-xs6qigg4	251	2	Schulz	Schulz	NNP
cord-002209-xs6qigg4	251	3	et	et	NNP
cord-002209-xs6qigg4	251	4	al	al	NNP
cord-002209-xs6qigg4	251	5	.	.	NNP
cord-002209-xs6qigg4	251	6	,	,	,
cord-002209-xs6qigg4	251	7	2012	2012	CD
cord-002209-xs6qigg4	251	8	)	)	-RRB-
cord-002209-xs6qigg4	251	9	.	.	.
cord-002209-xs6qigg4	252	1	As	as	IN
cord-002209-xs6qigg4	252	2	discussed	discuss	VBN
cord-002209-xs6qigg4	252	3	throughout	throughout	IN
cord-002209-xs6qigg4	252	4	this	this	DT
cord-002209-xs6qigg4	252	5	review	review	NN
cord-002209-xs6qigg4	252	6	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	252	7	can	can	MD
cord-002209-xs6qigg4	252	8	play	play	VB
cord-002209-xs6qigg4	252	9	important	important	JJ
cord-002209-xs6qigg4	252	10	roles	role	NNS
cord-002209-xs6qigg4	252	11	not	not	RB
cord-002209-xs6qigg4	252	12	just	just	RB
cord-002209-xs6qigg4	252	13	in	in	IN
cord-002209-xs6qigg4	252	14	myelination	myelination	NN
cord-002209-xs6qigg4	252	15	during	during	IN
cord-002209-xs6qigg4	252	16	development	development	NN
cord-002209-xs6qigg4	252	17	,	,	,
cord-002209-xs6qigg4	252	18	but	but	CC
cord-002209-xs6qigg4	252	19	also	also	RB
cord-002209-xs6qigg4	252	20	in	in	IN
cord-002209-xs6qigg4	252	21	remyelination	remyelination	NN
cord-002209-xs6qigg4	252	22	in	in	IN
cord-002209-xs6qigg4	252	23	adult	adult	NN
cord-002209-xs6qigg4	252	24	tissue	tissue	NN
cord-002209-xs6qigg4	252	25	after	after	IN
cord-002209-xs6qigg4	252	26	CNS	CNS	NNP
cord-002209-xs6qigg4	252	27	injury	injury	NN
cord-002209-xs6qigg4	252	28	.	.	.
cord-002209-xs6qigg4	253	1	Their	-PRON-	PRP$
cord-002209-xs6qigg4	253	2	reparative	reparative	JJ
cord-002209-xs6qigg4	253	3	roles	role	NNS
cord-002209-xs6qigg4	253	4	might	may	MD
cord-002209-xs6qigg4	253	5	be	be	VB
cord-002209-xs6qigg4	253	6	related	relate	VBN
cord-002209-xs6qigg4	253	7	to	to	IN
cord-002209-xs6qigg4	253	8	their	-PRON-	PRP$
cord-002209-xs6qigg4	253	9	level	level	NN
cord-002209-xs6qigg4	253	10	of	of	IN
cord-002209-xs6qigg4	253	11	reactivity	reactivity	NN
cord-002209-xs6qigg4	253	12	,	,	,
cord-002209-xs6qigg4	253	13	so	so	CC
cord-002209-xs6qigg4	253	14	it	-PRON-	PRP
cord-002209-xs6qigg4	253	15	is	be	VBZ
cord-002209-xs6qigg4	253	16	important	important	JJ
cord-002209-xs6qigg4	253	17	to	to	TO
cord-002209-xs6qigg4	253	18	identify	identify	VB
cord-002209-xs6qigg4	253	19	markers	marker	NNS
cord-002209-xs6qigg4	253	20	that	that	WDT
cord-002209-xs6qigg4	253	21	can	can	MD
cord-002209-xs6qigg4	253	22	define	define	VB
cord-002209-xs6qigg4	253	23	these	these	DT
cord-002209-xs6qigg4	253	24	different	different	JJ
cord-002209-xs6qigg4	253	25	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	253	26	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	253	27	although	although	IN
cord-002209-xs6qigg4	253	28	at	at	IN
cord-002209-xs6qigg4	253	29	present	present	JJ
cord-002209-xs6qigg4	253	30	these	these	DT
cord-002209-xs6qigg4	253	31	are	be	VBP
cord-002209-xs6qigg4	253	32	not	not	RB
cord-002209-xs6qigg4	253	33	easy	easy	JJ
cord-002209-xs6qigg4	253	34	to	to	TO
cord-002209-xs6qigg4	253	35	define	define	VB
cord-002209-xs6qigg4	253	36	.	.	.
cord-002209-xs6qigg4	254	1	One	one	CD
cord-002209-xs6qigg4	254	2	approach	approach	NN
cord-002209-xs6qigg4	254	3	is	be	VBZ
cord-002209-xs6qigg4	254	4	to	to	TO
cord-002209-xs6qigg4	254	5	use	use	VB
cord-002209-xs6qigg4	254	6	microarrays	microarray	NNS
cord-002209-xs6qigg4	254	7	.	.	.
cord-002209-xs6qigg4	255	1	As	as	IN
cord-002209-xs6qigg4	255	2	described	describe	VBN
cord-002209-xs6qigg4	255	3	,	,	,
cord-002209-xs6qigg4	255	4	Nash	Nash	NNP
cord-002209-xs6qigg4	255	5	et	et	NNP
cord-002209-xs6qigg4	255	6	al	al	NNP
cord-002209-xs6qigg4	255	7	.	.	.
cord-002209-xs6qigg4	256	1	(	(	-LRB-
cord-002209-xs6qigg4	256	2	2011b	2011b	CD
cord-002209-xs6qigg4	256	3	)	)	-RRB-
cord-002209-xs6qigg4	256	4	identified	identify	VBN
cord-002209-xs6qigg4	256	5	CXCL10	CXCL10	NNP
cord-002209-xs6qigg4	256	6	as	as	IN
cord-002209-xs6qigg4	256	7	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	256	8	to	to	IN
cord-002209-xs6qigg4	256	9	myelination	myelination	NN
cord-002209-xs6qigg4	256	10	,	,	,
cord-002209-xs6qigg4	256	11	but	but	CC
cord-002209-xs6qigg4	256	12	others	other	NNS
cord-002209-xs6qigg4	256	13	using	use	VBG
cord-002209-xs6qigg4	256	14	a	a	DT
cord-002209-xs6qigg4	256	15	lower	low	JJR
cord-002209-xs6qigg4	256	16	-	-	HYPH
cord-002209-xs6qigg4	256	17	scale	scale	NN
cord-002209-xs6qigg4	256	18	cDNA	cdna	NN
cord-002209-xs6qigg4	256	19	array	array	NN
cord-002209-xs6qigg4	256	20	that	that	WDT
cord-002209-xs6qigg4	256	21	contained	contain	VBD
cord-002209-xs6qigg4	256	22	probes	probe	NNS
cord-002209-xs6qigg4	256	23	for	for	IN
cord-002209-xs6qigg4	256	24	cytokines	cytokine	NNS
cord-002209-xs6qigg4	256	25	,	,	,
cord-002209-xs6qigg4	256	26	chemokines	chemokine	NNS
cord-002209-xs6qigg4	256	27	,	,	,
cord-002209-xs6qigg4	256	28	growth	growth	NN
cord-002209-xs6qigg4	256	29	factors	factor	NNS
cord-002209-xs6qigg4	256	30	and	and	CC
cord-002209-xs6qigg4	256	31	their	-PRON-	PRP$
cord-002209-xs6qigg4	256	32	receptors	receptor	NNS
cord-002209-xs6qigg4	256	33	have	have	VBP
cord-002209-xs6qigg4	256	34	identified	identify	VBN
cord-002209-xs6qigg4	256	35	other	other	JJ
cord-002209-xs6qigg4	256	36	pro	pro	JJ
cord-002209-xs6qigg4	256	37	-	-	JJ
cord-002209-xs6qigg4	256	38	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	256	39	cytokines	cytokine	NNS
cord-002209-xs6qigg4	256	40	including	include	VBG
cord-002209-xs6qigg4	256	41	TNF	TNF	NNP
cord-002209-xs6qigg4	256	42	-	-	HYPH
cord-002209-xs6qigg4	256	43	α	α	NNP
cord-002209-xs6qigg4	256	44	,	,	,
cord-002209-xs6qigg4	256	45	IL-1β	IL-1β	NNP
cord-002209-xs6qigg4	256	46	,	,	,
cord-002209-xs6qigg4	256	47	or	or	CC
cord-002209-xs6qigg4	256	48	IFN	IFN	NNP
cord-002209-xs6qigg4	256	49	-	-	HYPH
cord-002209-xs6qigg4	256	50	γ	γ	NNP
cord-002209-xs6qigg4	256	51	(	(	-LRB-
cord-002209-xs6qigg4	256	52	Meeuwsen	Meeuwsen	NNP
cord-002209-xs6qigg4	256	53	et	et	NNP
cord-002209-xs6qigg4	256	54	al	al	NNP
cord-002209-xs6qigg4	256	55	.	.	NNP
cord-002209-xs6qigg4	256	56	,	,	,
cord-002209-xs6qigg4	256	57	2003	2003	CD
cord-002209-xs6qigg4	256	58	)	)	-RRB-
cord-002209-xs6qigg4	256	59	.	.	.
cord-002209-xs6qigg4	257	1	Another	another	DT
cord-002209-xs6qigg4	257	2	large	large	JJ
cord-002209-xs6qigg4	257	3	array	array	NN
cord-002209-xs6qigg4	257	4	was	be	VBD
cord-002209-xs6qigg4	257	5	carried	carry	VBN
cord-002209-xs6qigg4	257	6	out	out	RP
cord-002209-xs6qigg4	257	7	on	on	IN
cord-002209-xs6qigg4	257	8	GFP	GFP	NNP
cord-002209-xs6qigg4	257	9	-	-	HYPH
cord-002209-xs6qigg4	257	10	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	257	11	purified	purify	VBN
cord-002209-xs6qigg4	257	12	at	at	IN
cord-002209-xs6qigg4	257	13	various	various	JJ
cord-002209-xs6qigg4	257	14	time	time	NN
cord-002209-xs6qigg4	257	15	points	point	NNS
cord-002209-xs6qigg4	257	16	after	after	IN
cord-002209-xs6qigg4	257	17	the	the	DT
cord-002209-xs6qigg4	257	18	onset	onset	NN
cord-002209-xs6qigg4	257	19	of	of	IN
cord-002209-xs6qigg4	257	20	two	two	CD
cord-002209-xs6qigg4	257	21	models	model	NNS
cord-002209-xs6qigg4	257	22	of	of	IN
cord-002209-xs6qigg4	257	23	disease	disease	NN
cord-002209-xs6qigg4	257	24	,	,	,
cord-002209-xs6qigg4	257	25	namely	namely	RB
cord-002209-xs6qigg4	257	26	ischemic	ischemic	JJ
cord-002209-xs6qigg4	257	27	stroke	stroke	NN
cord-002209-xs6qigg4	257	28	(	(	-LRB-
cord-002209-xs6qigg4	257	29	middle	middle	JJ
cord-002209-xs6qigg4	257	30	cerebral	cerebral	JJ
cord-002209-xs6qigg4	257	31	artery	artery	NN
cord-002209-xs6qigg4	257	32	occlusion	occlusion	NN
cord-002209-xs6qigg4	257	33	)	)	-RRB-
cord-002209-xs6qigg4	257	34	and	and	CC
cord-002209-xs6qigg4	257	35	neuroinflammation	neuroinflammation	NN
cord-002209-xs6qigg4	257	36	induced	induce	VBN
cord-002209-xs6qigg4	257	37	by	by	IN
cord-002209-xs6qigg4	257	38	LPS	LPS	NNP
cord-002209-xs6qigg4	257	39	injection	injection	NN
cord-002209-xs6qigg4	258	1	(	(	-LRB-
cord-002209-xs6qigg4	258	2	Zamanian	Zamanian	NNP
cord-002209-xs6qigg4	258	3	et	et	NNP
cord-002209-xs6qigg4	258	4	al	al	NNP
cord-002209-xs6qigg4	258	5	.	.	NNP
cord-002209-xs6qigg4	258	6	,	,	,
cord-002209-xs6qigg4	258	7	2012	2012	CD
cord-002209-xs6qigg4	258	8	)	)	-RRB-
cord-002209-xs6qigg4	258	9	.	.	.
cord-002209-xs6qigg4	259	1	The	the	DT
cord-002209-xs6qigg4	259	2	resulting	result	VBG
cord-002209-xs6qigg4	259	3	data	datum	NNS
cord-002209-xs6qigg4	259	4	suggested	suggest	VBD
cord-002209-xs6qigg4	259	5	that	that	IN
cord-002209-xs6qigg4	259	6	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	259	7	could	could	MD
cord-002209-xs6qigg4	259	8	present	present	VB
cord-002209-xs6qigg4	259	9	different	different	JJ
cord-002209-xs6qigg4	259	10	mRNA	mRNA	NNP
cord-002209-xs6qigg4	259	11	expression	expression	NN
cord-002209-xs6qigg4	259	12	profiles	profile	NNS
cord-002209-xs6qigg4	259	13	depending	depend	VBG
cord-002209-xs6qigg4	259	14	on	on	IN
cord-002209-xs6qigg4	259	15	the	the	DT
cord-002209-xs6qigg4	259	16	insult	insult	NN
cord-002209-xs6qigg4	259	17	despite	despite	IN
cord-002209-xs6qigg4	259	18	the	the	DT
cord-002209-xs6qigg4	259	19	presence	presence	NN
cord-002209-xs6qigg4	259	20	of	of	IN
cord-002209-xs6qigg4	259	21	reactive	reactive	JJ
cord-002209-xs6qigg4	259	22	gliosis	gliosis	NN
cord-002209-xs6qigg4	259	23	in	in	IN
cord-002209-xs6qigg4	259	24	both	both	DT
cord-002209-xs6qigg4	259	25	types	type	NNS
cord-002209-xs6qigg4	259	26	of	of	IN
cord-002209-xs6qigg4	259	27	CNS	CNS	NNP
cord-002209-xs6qigg4	259	28	damage	damage	NN
cord-002209-xs6qigg4	259	29	.	.	.
cord-002209-xs6qigg4	260	1	However	however	RB
cord-002209-xs6qigg4	260	2	,	,	,
cord-002209-xs6qigg4	260	3	although	although	IN
cord-002209-xs6qigg4	260	4	there	there	EX
cord-002209-xs6qigg4	260	5	was	be	VBD
cord-002209-xs6qigg4	260	6	upregulation	upregulation	NN
cord-002209-xs6qigg4	260	7	of	of	IN
cord-002209-xs6qigg4	260	8	a	a	DT
cord-002209-xs6qigg4	260	9	core	core	NN
cord-002209-xs6qigg4	260	10	set	set	NN
cord-002209-xs6qigg4	260	11	of	of	IN
cord-002209-xs6qigg4	260	12	genes	gene	NNS
cord-002209-xs6qigg4	260	13	(	(	-LRB-
cord-002209-xs6qigg4	260	14	lipocalin	lipocalin	NNP
cord-002209-xs6qigg4	260	15	2	2	CD
cord-002209-xs6qigg4	260	16	and	and	CC
cord-002209-xs6qigg4	260	17	serpina3n	serpina3n	NNP
cord-002209-xs6qigg4	260	18	)	)	-RRB-
cord-002209-xs6qigg4	260	19	,	,	,
cord-002209-xs6qigg4	260	20	it	-PRON-	PRP
cord-002209-xs6qigg4	260	21	was	be	VBD
cord-002209-xs6qigg4	260	22	clear	clear	JJ
cord-002209-xs6qigg4	260	23	that	that	IN
cord-002209-xs6qigg4	260	24	changes	change	NNS
cord-002209-xs6qigg4	260	25	in	in	IN
cord-002209-xs6qigg4	260	26	the	the	DT
cord-002209-xs6qigg4	260	27	astrocyte	astrocyte	NN
cord-002209-xs6qigg4	260	28	after	after	IN
cord-002209-xs6qigg4	260	29	injury	injury	NN
cord-002209-xs6qigg4	260	30	are	be	VBP
cord-002209-xs6qigg4	260	31	highly	highly	RB
cord-002209-xs6qigg4	260	32	heterogeneous	heterogeneous	JJ
cord-002209-xs6qigg4	260	33	,	,	,
cord-002209-xs6qigg4	260	34	and	and	CC
cord-002209-xs6qigg4	260	35	that	that	IN
cord-002209-xs6qigg4	260	36	changes	change	NNS
cord-002209-xs6qigg4	260	37	in	in	IN
cord-002209-xs6qigg4	260	38	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	260	39	activity	activity	NN
cord-002209-xs6qigg4	260	40	may	may	MD
cord-002209-xs6qigg4	260	41	depend	depend	VB
cord-002209-xs6qigg4	260	42	on	on	IN
cord-002209-xs6qigg4	260	43	the	the	DT
cord-002209-xs6qigg4	260	44	injury	injury	NN
cord-002209-xs6qigg4	260	45	type	type	NN
cord-002209-xs6qigg4	260	46	.	.	.
cord-002209-xs6qigg4	261	1	Hopefully	hopefully	RB
cord-002209-xs6qigg4	261	2	,	,	,
cord-002209-xs6qigg4	261	3	more	more	RBR
cord-002209-xs6qigg4	261	4	specific	specific	JJ
cord-002209-xs6qigg4	261	5	markers	marker	NNS
cord-002209-xs6qigg4	261	6	of	of	IN
cord-002209-xs6qigg4	261	7	"	"	``
cord-002209-xs6qigg4	261	8	good	good	JJ
cord-002209-xs6qigg4	261	9	"	"	''
cord-002209-xs6qigg4	261	10	or	or	CC
cord-002209-xs6qigg4	261	11	"	"	``
cord-002209-xs6qigg4	261	12	bad	bad	JJ
cord-002209-xs6qigg4	261	13	"	"	''
cord-002209-xs6qigg4	261	14	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	261	15	for	for	IN
cord-002209-xs6qigg4	261	16	CNS	CNS	NNP
cord-002209-xs6qigg4	261	17	repair	repair	NN
cord-002209-xs6qigg4	261	18	will	will	MD
cord-002209-xs6qigg4	261	19	be	be	VB
cord-002209-xs6qigg4	261	20	identified	identify	VBN
cord-002209-xs6qigg4	261	21	and	and	CC
cord-002209-xs6qigg4	261	22	allow	allow	VB
cord-002209-xs6qigg4	261	23	more	more	RBR
cord-002209-xs6qigg4	261	24	specific	specific	JJ
cord-002209-xs6qigg4	261	25	identification	identification	NN
cord-002209-xs6qigg4	261	26	of	of	IN
cord-002209-xs6qigg4	261	27	how	how	WRB
cord-002209-xs6qigg4	261	28	these	these	DT
cord-002209-xs6qigg4	261	29	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	261	30	influence	influence	VBP
cord-002209-xs6qigg4	261	31	repair	repair	NN
cord-002209-xs6qigg4	261	32	.	.	.
cord-002209-xs6qigg4	262	1	There	there	EX
cord-002209-xs6qigg4	262	2	is	be	VBZ
cord-002209-xs6qigg4	262	3	abundant	abundant	JJ
cord-002209-xs6qigg4	262	4	evidence	evidence	NN
cord-002209-xs6qigg4	262	5	to	to	TO
cord-002209-xs6qigg4	262	6	suggest	suggest	VB
cord-002209-xs6qigg4	262	7	that	that	IN
cord-002209-xs6qigg4	262	8	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	262	9	contribute	contribute	VBP
cord-002209-xs6qigg4	262	10	to	to	IN
cord-002209-xs6qigg4	262	11	re	re	NN
cord-002209-xs6qigg4	262	12	/	/	NN
cord-002209-xs6qigg4	262	13	myelination	myelination	NN
cord-002209-xs6qigg4	262	14	mainly	mainly	RB
cord-002209-xs6qigg4	262	15	by	by	IN
cord-002209-xs6qigg4	262	16	:	:	:
cord-002209-xs6qigg4	262	17	1	1	LS
cord-002209-xs6qigg4	262	18	)	)	-RRB-
cord-002209-xs6qigg4	262	19	Providing	provide	VBG
cord-002209-xs6qigg4	262	20	the	the	DT
cord-002209-xs6qigg4	262	21	right	right	JJ
cord-002209-xs6qigg4	262	22	conditions	condition	NNS
cord-002209-xs6qigg4	262	23	for	for	IN
cord-002209-xs6qigg4	262	24	neurons	neuron	NNS
cord-002209-xs6qigg4	262	25	to	to	TO
cord-002209-xs6qigg4	262	26	myelinate	myelinate	VB
cord-002209-xs6qigg4	262	27	by	by	IN
cord-002209-xs6qigg4	262	28	i	i	NNP
cord-002209-xs6qigg4	262	29	)	)	-RRB-
cord-002209-xs6qigg4	262	30	supplying	supply	VBG
cord-002209-xs6qigg4	262	31	neurons	neuron	NNS
cord-002209-xs6qigg4	262	32	with	with	IN
cord-002209-xs6qigg4	262	33	energy	energy	NN
cord-002209-xs6qigg4	262	34	and	and	CC
cord-002209-xs6qigg4	262	35	cholesterol	cholesterol	NN
cord-002209-xs6qigg4	262	36	,	,	,
cord-002209-xs6qigg4	262	37	ii	ii	LS
cord-002209-xs6qigg4	262	38	)	)	-RRB-
cord-002209-xs6qigg4	262	39	removing	remove	VBG
cord-002209-xs6qigg4	262	40	excitotoxic	excitotoxic	JJ
cord-002209-xs6qigg4	262	41	molecules	molecule	NNS
cord-002209-xs6qigg4	262	42	from	from	IN
cord-002209-xs6qigg4	262	43	the	the	DT
cord-002209-xs6qigg4	262	44	extracellular	extracellular	JJ
cord-002209-xs6qigg4	262	45	environment	environment	NN
cord-002209-xs6qigg4	262	46	,	,	,
cord-002209-xs6qigg4	262	47	and	and	CC
cord-002209-xs6qigg4	262	48	iii	iii	LS
cord-002209-xs6qigg4	262	49	)	)	-RRB-
cord-002209-xs6qigg4	262	50	regulating	regulate	VBG
cord-002209-xs6qigg4	262	51	the	the	DT
cord-002209-xs6qigg4	262	52	fluid	fluid	NN
cord-002209-xs6qigg4	262	53	,	,	,
cord-002209-xs6qigg4	262	54	ion	ion	NN
cord-002209-xs6qigg4	262	55	,	,	,
cord-002209-xs6qigg4	262	56	pH	pH	NNP
cord-002209-xs6qigg4	262	57	,	,	,
cord-002209-xs6qigg4	262	58	and	and	CC
cord-002209-xs6qigg4	262	59	neuro	neuro	NNP
cord-002209-xs6qigg4	262	60	/	/	SYM
cord-002209-xs6qigg4	262	61	gliotransmitter	gliotransmitter	NNP
cord-002209-xs6qigg4	262	62	homeostasis	homeostasis	NN
cord-002209-xs6qigg4	262	63	.	.	.
cord-002209-xs6qigg4	263	1	2	2	LS
cord-002209-xs6qigg4	263	2	)	)	-RRB-
cord-002209-xs6qigg4	263	3	Playing	play	VBG
cord-002209-xs6qigg4	263	4	a	a	DT
cord-002209-xs6qigg4	263	5	role	role	NN
cord-002209-xs6qigg4	263	6	in	in	IN
cord-002209-xs6qigg4	263	7	the	the	DT
cord-002209-xs6qigg4	263	8	survival	survival	NN
cord-002209-xs6qigg4	263	9	,	,	,
cord-002209-xs6qigg4	263	10	proliferation	proliferation	NN
cord-002209-xs6qigg4	263	11	,	,	,
cord-002209-xs6qigg4	263	12	maturation	maturation	NN
cord-002209-xs6qigg4	263	13	and	and	CC
cord-002209-xs6qigg4	263	14	function	function	NN
cord-002209-xs6qigg4	263	15	of	of	IN
cord-002209-xs6qigg4	263	16	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	263	17	and	and	CC
cord-002209-xs6qigg4	263	18	the	the	DT
cord-002209-xs6qigg4	263	19	migration	migration	NN
cord-002209-xs6qigg4	263	20	of	of	IN
cord-002209-xs6qigg4	263	21	OPCs	opc	NNS
cord-002209-xs6qigg4	263	22	into	into	IN
cord-002209-xs6qigg4	263	23	the	the	DT
cord-002209-xs6qigg4	263	24	lesioned	lesione	VBN
cord-002209-xs6qigg4	263	25	areas	area	NNS
cord-002209-xs6qigg4	263	26	in	in	IN
cord-002209-xs6qigg4	263	27	the	the	DT
cord-002209-xs6qigg4	263	28	CNS	CNS	NNP
cord-002209-xs6qigg4	263	29	.	.	.
cord-002209-xs6qigg4	264	1	3	3	LS
cord-002209-xs6qigg4	264	2	)	)	-RRB-
cord-002209-xs6qigg4	265	1	Influencing	influence	VBG
cord-002209-xs6qigg4	265	2	microglia	microglia	NNS
cord-002209-xs6qigg4	265	3	.	.	.
cord-002209-xs6qigg4	266	1	The	the	DT
cord-002209-xs6qigg4	266	2	manner	manner	NN
cord-002209-xs6qigg4	266	3	by	by	IN
cord-002209-xs6qigg4	266	4	which	which	WDT
cord-002209-xs6qigg4	266	5	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	266	6	affect	affect	VBP
cord-002209-xs6qigg4	266	7	myelination	myelination	NN
cord-002209-xs6qigg4	266	8	can	can	MD
cord-002209-xs6qigg4	266	9	often	often	RB
cord-002209-xs6qigg4	266	10	be	be	VB
cord-002209-xs6qigg4	266	11	seen	see	VBN
cord-002209-xs6qigg4	266	12	to	to	TO
cord-002209-xs6qigg4	266	13	correlate	correlate	VB
cord-002209-xs6qigg4	266	14	with	with	IN
cord-002209-xs6qigg4	266	15	its	-PRON-	PRP$
cord-002209-xs6qigg4	266	16	level	level	NN
cord-002209-xs6qigg4	266	17	of	of	IN
cord-002209-xs6qigg4	266	18	reactivity	reactivity	NN
cord-002209-xs6qigg4	266	19	.	.	.
cord-002209-xs6qigg4	267	1	Astrocyte	Astrocyte	NNP
cord-002209-xs6qigg4	267	2	reactivity	reactivity	NN
cord-002209-xs6qigg4	267	3	can	can	MD
cord-002209-xs6qigg4	267	4	be	be	VB
cord-002209-xs6qigg4	267	5	induced	induce	VBN
cord-002209-xs6qigg4	267	6	by	by	IN
cord-002209-xs6qigg4	267	7	the	the	DT
cord-002209-xs6qigg4	267	8	milieu	milieu	NN
cord-002209-xs6qigg4	267	9	of	of	IN
cord-002209-xs6qigg4	267	10	cytokines	cytokine	NNS
cord-002209-xs6qigg4	267	11	present	present	JJ
cord-002209-xs6qigg4	267	12	after	after	IN
cord-002209-xs6qigg4	267	13	injury	injury	NN
cord-002209-xs6qigg4	267	14	,	,	,
cord-002209-xs6qigg4	267	15	which	which	WDT
cord-002209-xs6qigg4	267	16	can	can	MD
cord-002209-xs6qigg4	267	17	be	be	VB
cord-002209-xs6qigg4	267	18	beneficial	beneficial	JJ
cord-002209-xs6qigg4	267	19	or	or	CC
cord-002209-xs6qigg4	267	20	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	267	21	in	in	IN
cord-002209-xs6qigg4	267	22	re	re	NN
cord-002209-xs6qigg4	267	23	/	/	NN
cord-002209-xs6qigg4	267	24	myelination	myelination	NN
cord-002209-xs6qigg4	267	25	depending	depend	VBG
cord-002209-xs6qigg4	267	26	on	on	IN
cord-002209-xs6qigg4	267	27	the	the	DT
cord-002209-xs6qigg4	267	28	context	context	NN
cord-002209-xs6qigg4	267	29	and	and	CC
cord-002209-xs6qigg4	267	30	severity	severity	NN
cord-002209-xs6qigg4	267	31	of	of	IN
cord-002209-xs6qigg4	267	32	the	the	DT
cord-002209-xs6qigg4	267	33	injury	injury	NN
cord-002209-xs6qigg4	267	34	.	.	.
cord-002209-xs6qigg4	268	1	Due	due	IN
cord-002209-xs6qigg4	268	2	to	to	IN
cord-002209-xs6qigg4	268	3	the	the	DT
cord-002209-xs6qigg4	268	4	lack	lack	NN
cord-002209-xs6qigg4	268	5	of	of	IN
cord-002209-xs6qigg4	268	6	gliosis	gliosis	NN
cord-002209-xs6qigg4	268	7	-	-	HYPH
cord-002209-xs6qigg4	268	8	specific	specific	JJ
cord-002209-xs6qigg4	268	9	markers	marker	NNS
cord-002209-xs6qigg4	268	10	,	,	,
cord-002209-xs6qigg4	268	11	there	there	EX
cord-002209-xs6qigg4	268	12	are	be	VBP
cord-002209-xs6qigg4	268	13	currently	currently	RB
cord-002209-xs6qigg4	268	14	no	no	DT
cord-002209-xs6qigg4	268	15	clear	clear	JJ
cord-002209-xs6qigg4	268	16	guidelines	guideline	NNS
cord-002209-xs6qigg4	268	17	which	which	WDT
cord-002209-xs6qigg4	268	18	allow	allow	VBP
cord-002209-xs6qigg4	268	19	different	different	JJ
cord-002209-xs6qigg4	268	20	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	268	21	reactivity	reactivity	NN
cord-002209-xs6qigg4	268	22	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	268	23	to	to	TO
cord-002209-xs6qigg4	268	24	be	be	VB
cord-002209-xs6qigg4	268	25	classified	classify	VBN
cord-002209-xs6qigg4	268	26	.	.	.
cord-002209-xs6qigg4	269	1	However	however	RB
cord-002209-xs6qigg4	269	2	,	,	,
cord-002209-xs6qigg4	269	3	if	if	IN
cord-002209-xs6qigg4	269	4	markers	marker	NNS
cord-002209-xs6qigg4	269	5	can	can	MD
cord-002209-xs6qigg4	269	6	be	be	VB
cord-002209-xs6qigg4	269	7	identified	identify	VBN
cord-002209-xs6qigg4	269	8	that	that	WDT
cord-002209-xs6qigg4	269	9	classify	classify	VBP
cord-002209-xs6qigg4	269	10	the	the	DT
cord-002209-xs6qigg4	269	11	continuum	continuum	NN
cord-002209-xs6qigg4	269	12	of	of	IN
cord-002209-xs6qigg4	269	13	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	269	14	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	269	15	,	,	,
cord-002209-xs6qigg4	269	16	it	-PRON-	PRP
cord-002209-xs6qigg4	269	17	may	may	MD
cord-002209-xs6qigg4	269	18	aid	aid	VB
cord-002209-xs6qigg4	269	19	in	in	IN
cord-002209-xs6qigg4	269	20	the	the	DT
cord-002209-xs6qigg4	269	21	design	design	NN
cord-002209-xs6qigg4	269	22	of	of	IN
cord-002209-xs6qigg4	269	23	new	new	JJ
cord-002209-xs6qigg4	269	24	treatments	treatment	NNS
cord-002209-xs6qigg4	269	25	targeting	target	VBG
cord-002209-xs6qigg4	269	26	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	269	27	that	that	WDT
cord-002209-xs6qigg4	269	28	are	be	VBP
cord-002209-xs6qigg4	269	29	more	more	RBR
cord-002209-xs6qigg4	269	30	suited	suited	JJ
cord-002209-xs6qigg4	269	31	to	to	IN
cord-002209-xs6qigg4	269	32	regeneration	regeneration	NN
cord-002209-xs6qigg4	269	33	and	and	CC
cord-002209-xs6qigg4	269	34	remyelination	remyelination	NN
cord-002209-xs6qigg4	269	35	,	,	,
cord-002209-xs6qigg4	269	36	and	and	CC
cord-002209-xs6qigg4	269	37	therefore	therefore	RB
cord-002209-xs6qigg4	269	38	benefit	benefit	VBP
cord-002209-xs6qigg4	269	39	in	in	IN
cord-002209-xs6qigg4	269	40	the	the	DT
cord-002209-xs6qigg4	269	41	treatment	treatment	NN
cord-002209-xs6qigg4	269	42	of	of	IN
cord-002209-xs6qigg4	269	43	demyelinating	demyelinate	VBG
cord-002209-xs6qigg4	269	44	diseases	disease	NNS
cord-002209-xs6qigg4	269	45	.	.	.
cord-002209-xs6qigg4	270	1	Ciliary	ciliary	JJ
cord-002209-xs6qigg4	270	2	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	270	3	factor	factor	NN
cord-002209-xs6qigg4	270	4	activates	activate	VBZ
cord-002209-xs6qigg4	270	5	spinal	spinal	JJ
cord-002209-xs6qigg4	270	6	cord	cord	NN
cord-002209-xs6qigg4	270	7	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	270	8	,	,	,
cord-002209-xs6qigg4	270	9	stimulating	stimulate	VBG
cord-002209-xs6qigg4	270	10	their	-PRON-	PRP$
cord-002209-xs6qigg4	270	11	production	production	NN
cord-002209-xs6qigg4	270	12	and	and	CC
cord-002209-xs6qigg4	270	13	release	release	NN
cord-002209-xs6qigg4	270	14	of	of	IN
cord-002209-xs6qigg4	270	15	fibroblast	fibroblast	NN
cord-002209-xs6qigg4	270	16	growth	growth	NN
cord-002209-xs6qigg4	270	17	factor-2	factor-2	RB
cord-002209-xs6qigg4	270	18	,	,	,
cord-002209-xs6qigg4	270	19	to	to	TO
cord-002209-xs6qigg4	270	20	increase	increase	VB
cord-002209-xs6qigg4	270	21	motor	motor	NN
cord-002209-xs6qigg4	270	22	neuron	neuron	NN
cord-002209-xs6qigg4	270	23	survival	survival	NN
cord-002209-xs6qigg4	270	24	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	270	25	produce	produce	VBP
cord-002209-xs6qigg4	270	26	CNTF	CNTF	NNP
cord-002209-xs6qigg4	270	27	during	during	IN
cord-002209-xs6qigg4	270	28	the	the	DT
cord-002209-xs6qigg4	270	29	remyelination	remyelination	NN
cord-002209-xs6qigg4	270	30	phase	phase	NN
cord-002209-xs6qigg4	270	31	of	of	IN
cord-002209-xs6qigg4	270	32	viral	viral	JJ
cord-002209-xs6qigg4	270	33	-	-	HYPH
cord-002209-xs6qigg4	270	34	induced	induce	VBN
cord-002209-xs6qigg4	270	35	spinal	spinal	JJ
cord-002209-xs6qigg4	270	36	cord	cord	NN
cord-002209-xs6qigg4	270	37	demyelination	demyelination	NN
cord-002209-xs6qigg4	270	38	to	to	TO
cord-002209-xs6qigg4	270	39	stimulate	stimulate	VB
cord-002209-xs6qigg4	270	40	FGF-2	FGF-2	NNP
cord-002209-xs6qigg4	270	41	production	production	NN
cord-002209-xs6qigg4	270	42	CNTF	CNTF	NNP
cord-002209-xs6qigg4	270	43	-	-	HYPH
cord-002209-xs6qigg4	270	44	activated	activate	VBN
cord-002209-xs6qigg4	270	45	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	270	46	release	release	VBP
cord-002209-xs6qigg4	270	47	a	a	DT
cord-002209-xs6qigg4	270	48	soluble	soluble	JJ
cord-002209-xs6qigg4	270	49	trophic	trophic	JJ
cord-002209-xs6qigg4	270	50	activity	activity	NN
cord-002209-xs6qigg4	270	51	for	for	IN
cord-002209-xs6qigg4	270	52	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	270	53	progenitors	progenitor	NNS
cord-002209-xs6qigg4	270	54	Regulation	Regulation	NNP
cord-002209-xs6qigg4	270	55	of	of	IN
cord-002209-xs6qigg4	270	56	leukemia	leukemia	NN
cord-002209-xs6qigg4	270	57	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	270	58	factor	factor	NN
cord-002209-xs6qigg4	270	59	synthesis	synthesis	NN
cord-002209-xs6qigg4	270	60	in	in	IN
cord-002209-xs6qigg4	270	61	cultured	cultured	JJ
cord-002209-xs6qigg4	270	62	human	human	NN
cord-002209-xs6qigg4	270	63	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	271	1	Delayed	delay	VBN
cord-002209-xs6qigg4	271	2	K+	k+	JJ
cord-002209-xs6qigg4	271	3	clearance	clearance	NN
cord-002209-xs6qigg4	271	4	associated	associate	VBN
cord-002209-xs6qigg4	271	5	with	with	IN
cord-002209-xs6qigg4	271	6	aquaporin-4	aquaporin-4	NNP
cord-002209-xs6qigg4	271	7	mislocalization	mislocalization	NN
cord-002209-xs6qigg4	271	8	:	:	:
cord-002209-xs6qigg4	271	9	phenotypic	phenotypic	JJ
cord-002209-xs6qigg4	271	10	defects	defect	NNS
cord-002209-xs6qigg4	271	11	in	in	IN
cord-002209-xs6qigg4	271	12	brains	brain	NNS
cord-002209-xs6qigg4	271	13	of	of	IN
cord-002209-xs6qigg4	271	14	alphasyntrophin	alphasyntrophin	NN
cord-002209-xs6qigg4	271	15	-	-	HYPH
cord-002209-xs6qigg4	271	16	null	null	JJ
cord-002209-xs6qigg4	271	17	mice	mouse	NNS
cord-002209-xs6qigg4	272	1	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	272	2	protect	protect	VBP
cord-002209-xs6qigg4	272	3	oligodendrocyte	oligodendrocyte	JJ
cord-002209-xs6qigg4	272	4	precursor	precursor	NN
cord-002209-xs6qigg4	272	5	cells	cell	NNS
cord-002209-xs6qigg4	272	6	via	via	IN
cord-002209-xs6qigg4	272	7	MEK	MEK	NNP
cord-002209-xs6qigg4	272	8	/	/	SYM
cord-002209-xs6qigg4	272	9	ERK	ERK	NNP
cord-002209-xs6qigg4	272	10	and	and	CC
cord-002209-xs6qigg4	272	11	PI3K	PI3K	NNP
cord-002209-xs6qigg4	272	12	/	/	SYM
cord-002209-xs6qigg4	272	13	Akt	Akt	NNP
cord-002209-xs6qigg4	272	14	signaling	signal	VBG
cord-002209-xs6qigg4	272	15	Glutamate	glutamate	NN
cord-002209-xs6qigg4	272	16	-	-	HYPH
cord-002209-xs6qigg4	272	17	dependent	dependent	JJ
cord-002209-xs6qigg4	272	18	astrocyte	astrocyte	JJ
cord-002209-xs6qigg4	272	19	modulation	modulation	NN
cord-002209-xs6qigg4	272	20	of	of	IN
cord-002209-xs6qigg4	272	21	synaptic	synaptic	JJ
cord-002209-xs6qigg4	272	22	transmission	transmission	NN
cord-002209-xs6qigg4	272	23	between	between	IN
cord-002209-xs6qigg4	272	24	cultured	cultured	JJ
cord-002209-xs6qigg4	272	25	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	272	26	neurons	neuron	NNS
cord-002209-xs6qigg4	272	27	Tripartite	tripartite	JJ
cord-002209-xs6qigg4	272	28	synapses	synapsis	NNS
cord-002209-xs6qigg4	272	29	:	:	:
cord-002209-xs6qigg4	272	30	glia	glia	NNP
cord-002209-xs6qigg4	272	31	,	,	,
cord-002209-xs6qigg4	272	32	the	the	DT
cord-002209-xs6qigg4	272	33	unacknowledged	unacknowledged	JJ
cord-002209-xs6qigg4	272	34	partner	partner	NN
cord-002209-xs6qigg4	273	1	The	the	DT
cord-002209-xs6qigg4	273	2	receptor	receptor	NN
cord-002209-xs6qigg4	273	3	for	for	IN
cord-002209-xs6qigg4	273	4	tumor	tumor	NN
cord-002209-xs6qigg4	273	5	necrosis	necrosis	NN
cord-002209-xs6qigg4	273	6	factor	factor	NN
cord-002209-xs6qigg4	273	7	on	on	IN
cord-002209-xs6qigg4	273	8	murine	murine	JJ
cord-002209-xs6qigg4	273	9	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	273	10	:	:	:
cord-002209-xs6qigg4	273	11	characterization	characterization	NN
cord-002209-xs6qigg4	273	12	,	,	,
cord-002209-xs6qigg4	273	13	intracellular	intracellular	JJ
cord-002209-xs6qigg4	273	14	degradation	degradation	NN
cord-002209-xs6qigg4	273	15	,	,	,
cord-002209-xs6qigg4	273	16	and	and	CC
cord-002209-xs6qigg4	273	17	regulation	regulation	NN
cord-002209-xs6qigg4	273	18	by	by	IN
cord-002209-xs6qigg4	273	19	cytokines	cytokine	NNS
cord-002209-xs6qigg4	273	20	and	and	CC
cord-002209-xs6qigg4	273	21	Theiler	Theiler	NNP
cord-002209-xs6qigg4	273	22	's	's	POS
cord-002209-xs6qigg4	273	23	murine	murine	JJ
cord-002209-xs6qigg4	273	24	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	273	25	virus	virus	NN
cord-002209-xs6qigg4	274	1	The	the	DT
cord-002209-xs6qigg4	274	2	interleukin	interleukin	NN
cord-002209-xs6qigg4	274	3	1	1	CD
cord-002209-xs6qigg4	274	4	receptor	receptor	NN
cord-002209-xs6qigg4	274	5	:	:	:
cord-002209-xs6qigg4	274	6	ligand	ligand	NN
cord-002209-xs6qigg4	274	7	interactions	interaction	NNS
cord-002209-xs6qigg4	274	8	and	and	CC
cord-002209-xs6qigg4	274	9	signal	signal	NN
cord-002209-xs6qigg4	274	10	transduction	transduction	NN
cord-002209-xs6qigg4	274	11	Myelination	myelination	NN
cord-002209-xs6qigg4	274	12	:	:	:
cord-002209-xs6qigg4	274	13	do	do	VB
cord-002209-xs6qigg4	274	14	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	274	15	play	play	VB
cord-002209-xs6qigg4	274	16	a	a	DT
cord-002209-xs6qigg4	274	17	role	role	NN
cord-002209-xs6qigg4	274	18	?	?	.
cord-002209-xs6qigg4	275	1	The	the	DT
cord-002209-xs6qigg4	275	2	mystery	mystery	NN
cord-002209-xs6qigg4	275	3	and	and	CC
cord-002209-xs6qigg4	275	4	magic	magic	NN
cord-002209-xs6qigg4	275	5	of	of	IN
cord-002209-xs6qigg4	275	6	glia	glia	NNP
cord-002209-xs6qigg4	275	7	:	:	:
cord-002209-xs6qigg4	275	8	a	a	DT
cord-002209-xs6qigg4	275	9	perspective	perspective	NN
cord-002209-xs6qigg4	275	10	on	on	IN
cord-002209-xs6qigg4	275	11	their	-PRON-	PRP$
cord-002209-xs6qigg4	275	12	roles	role	NNS
cord-002209-xs6qigg4	275	13	in	in	IN
cord-002209-xs6qigg4	275	14	health	health	NN
cord-002209-xs6qigg4	275	15	and	and	CC
cord-002209-xs6qigg4	275	16	disease	disease	NNP
cord-002209-xs6qigg4	275	17	Locus	Locus	NNP
cord-002209-xs6qigg4	275	18	coeruleus	coeruleu	VBZ
cord-002209-xs6qigg4	275	19	alpha	alpha	JJ
cord-002209-xs6qigg4	275	20	-	-	HYPH
cord-002209-xs6qigg4	275	21	adrenergic	adrenergic	NN
cord-002209-xs6qigg4	275	22	-	-	HYPH
cord-002209-xs6qigg4	275	23	mediated	mediate	VBN
cord-002209-xs6qigg4	275	24	activation	activation	NN
cord-002209-xs6qigg4	275	25	of	of	IN
cord-002209-xs6qigg4	275	26	cortical	cortical	JJ
cord-002209-xs6qigg4	275	27	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	275	28	in	in	IN
cord-002209-xs6qigg4	275	29	vivo	vivo	NNP
cord-002209-xs6qigg4	275	30	Synaptic	synaptic	JJ
cord-002209-xs6qigg4	275	31	activation	activation	NN
cord-002209-xs6qigg4	275	32	of	of	IN
cord-002209-xs6qigg4	275	33	glutamate	glutamate	NN
cord-002209-xs6qigg4	275	34	transporters	transporter	NNS
cord-002209-xs6qigg4	275	35	in	in	IN
cord-002209-xs6qigg4	275	36	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	275	37	astrocytes	astrocyte	VBZ
cord-002209-xs6qigg4	275	38	Prostaglandins	prostaglandin	NNS
cord-002209-xs6qigg4	275	39	stimulate	stimulate	VBP
cord-002209-xs6qigg4	275	40	calcium	calcium	NN
cord-002209-xs6qigg4	275	41	-	-	HYPH
cord-002209-xs6qigg4	275	42	dependent	dependent	JJ
cord-002209-xs6qigg4	275	43	glutamate	glutamate	NN
cord-002209-xs6qigg4	275	44	release	release	NN
cord-002209-xs6qigg4	275	45	in	in	IN
cord-002209-xs6qigg4	275	46	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	275	47	Tumour	tumour	NN
cord-002209-xs6qigg4	275	48	necrosis	necrosis	NN
cord-002209-xs6qigg4	275	49	factor	factor	NN
cord-002209-xs6qigg4	275	50	alpha	alpha	NN
cord-002209-xs6qigg4	275	51	mRNA	mRNA	NNP
cord-002209-xs6qigg4	275	52	expression	expression	NN
cord-002209-xs6qigg4	275	53	in	in	IN
cord-002209-xs6qigg4	275	54	early	early	JJ
cord-002209-xs6qigg4	275	55	multiple	multiple	JJ
cord-002209-xs6qigg4	275	56	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	275	57	lesions	lesion	NNS
cord-002209-xs6qigg4	275	58	:	:	:
cord-002209-xs6qigg4	275	59	correlation	correlation	NN
cord-002209-xs6qigg4	275	60	with	with	IN
cord-002209-xs6qigg4	275	61	demyelinating	demyelinate	VBG
cord-002209-xs6qigg4	275	62	activity	activity	NN
cord-002209-xs6qigg4	275	63	and	and	CC
cord-002209-xs6qigg4	275	64	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	275	65	pathology	pathology	NN
cord-002209-xs6qigg4	275	66	Cooperation	Cooperation	NNP
cord-002209-xs6qigg4	275	67	between	between	IN
cord-002209-xs6qigg4	275	68	two	two	CD
cord-002209-xs6qigg4	275	69	growth	growth	NN
cord-002209-xs6qigg4	275	70	factors	factor	NNS
cord-002209-xs6qigg4	275	71	promotes	promote	VBZ
cord-002209-xs6qigg4	275	72	extended	extended	JJ
cord-002209-xs6qigg4	275	73	self	self	NN
cord-002209-xs6qigg4	275	74	-	-	HYPH
cord-002209-xs6qigg4	275	75	renewal	renewal	NN
cord-002209-xs6qigg4	275	76	and	and	CC
cord-002209-xs6qigg4	275	77	inhibits	inhibit	VBZ
cord-002209-xs6qigg4	275	78	differentiation	differentiation	NN
cord-002209-xs6qigg4	275	79	of	of	IN
cord-002209-xs6qigg4	275	80	oligodendrocyte	oligodendrocyte	CD
cord-002209-xs6qigg4	275	81	-	-	HYPH
cord-002209-xs6qigg4	275	82	type-2	type-2	NN
cord-002209-xs6qigg4	275	83	astrocyte	astrocyte	NN
cord-002209-xs6qigg4	275	84	(	(	-LRB-
cord-002209-xs6qigg4	275	85	O-2	O-2	NNP
cord-002209-xs6qigg4	275	86	A	A	NNP
cord-002209-xs6qigg4	275	87	)	)	-RRB-
cord-002209-xs6qigg4	276	1	progenitor	progenitor	NN
cord-002209-xs6qigg4	276	2	cells	cell	NNS
cord-002209-xs6qigg4	277	1	Apolipoprotein	Apolipoprotein	NNP
cord-002209-xs6qigg4	277	2	E	E	NNP
cord-002209-xs6qigg4	277	3	associated	associate	VBN
cord-002209-xs6qigg4	277	4	with	with	IN
cord-002209-xs6qigg4	277	5	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	277	6	glia	glia	NNS
cord-002209-xs6qigg4	277	7	of	of	IN
cord-002209-xs6qigg4	277	8	the	the	DT
cord-002209-xs6qigg4	277	9	central	central	JJ
cord-002209-xs6qigg4	277	10	nervous	nervous	JJ
cord-002209-xs6qigg4	277	11	system	system	NN
cord-002209-xs6qigg4	277	12	and	and	CC
cord-002209-xs6qigg4	277	13	with	with	IN
cord-002209-xs6qigg4	277	14	nonmyelinating	nonmyelinate	VBG
cord-002209-xs6qigg4	277	15	glia	glia	NNP
cord-002209-xs6qigg4	277	16	of	of	IN
cord-002209-xs6qigg4	277	17	the	the	DT
cord-002209-xs6qigg4	277	18	peripheral	peripheral	JJ
cord-002209-xs6qigg4	277	19	nervous	nervous	JJ
cord-002209-xs6qigg4	277	20	system	system	NN
cord-002209-xs6qigg4	277	21	Mutations	Mutations	NNPS
cord-002209-xs6qigg4	277	22	in	in	IN
cord-002209-xs6qigg4	277	23	GFAP	GFAP	NNP
cord-002209-xs6qigg4	277	24	,	,	,
cord-002209-xs6qigg4	277	25	encoding	encode	VBG
cord-002209-xs6qigg4	277	26	glial	glial	JJ
cord-002209-xs6qigg4	277	27	fibrillary	fibrillary	JJ
cord-002209-xs6qigg4	277	28	acidic	acidic	JJ
cord-002209-xs6qigg4	277	29	protein	protein	NN
cord-002209-xs6qigg4	277	30	,	,	,
cord-002209-xs6qigg4	277	31	are	be	VBP
cord-002209-xs6qigg4	277	32	associated	associate	VBN
cord-002209-xs6qigg4	277	33	with	with	IN
cord-002209-xs6qigg4	277	34	Alexander	Alexander	NNP
cord-002209-xs6qigg4	277	35	disease	disease	NN
cord-002209-xs6qigg4	277	36	Analysis	Analysis	NNP
cord-002209-xs6qigg4	277	37	of	of	IN
cord-002209-xs6qigg4	277	38	neuronal	neuronal	JJ
cord-002209-xs6qigg4	277	39	and	and	CC
cord-002209-xs6qigg4	277	40	glial	glial	JJ
cord-002209-xs6qigg4	277	41	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	277	42	in	in	IN
cord-002209-xs6qigg4	277	43	brains	brain	NNS
cord-002209-xs6qigg4	277	44	of	of	IN
cord-002209-xs6qigg4	277	45	mice	mouse	NNS
cord-002209-xs6qigg4	277	46	deficient	deficient	JJ
cord-002209-xs6qigg4	277	47	in	in	IN
cord-002209-xs6qigg4	277	48	leukemia	leukemia	NN
cord-002209-xs6qigg4	277	49	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	277	50	factor	factor	NN
cord-002209-xs6qigg4	277	51	LIF	LIF	NNP
cord-002209-xs6qigg4	277	52	receptor	receptor	NN
cord-002209-xs6qigg4	277	53	signaling	signal	VBG
cord-002209-xs6qigg4	277	54	limits	limit	NNS
cord-002209-xs6qigg4	277	55	immune	immune	JJ
cord-002209-xs6qigg4	277	56	-	-	HYPH
cord-002209-xs6qigg4	277	57	mediated	mediate	VBN
cord-002209-xs6qigg4	277	58	demyelination	demyelination	NN
cord-002209-xs6qigg4	277	59	by	by	IN
cord-002209-xs6qigg4	277	60	enhancing	enhance	VBG
cord-002209-xs6qigg4	277	61	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	277	62	survival	survival	NN
cord-002209-xs6qigg4	277	63	Maturation	Maturation	NNP
cord-002209-xs6qigg4	277	64	of	of	IN
cord-002209-xs6qigg4	277	65	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	277	66	is	be	VBZ
cord-002209-xs6qigg4	277	67	more	more	RBR
cord-002209-xs6qigg4	277	68	sensitive	sensitive	JJ
cord-002209-xs6qigg4	277	69	to	to	IN
cord-002209-xs6qigg4	277	70	TNF	TNF	NNP
cord-002209-xs6qigg4	277	71	alpha	alpha	NN
cord-002209-xs6qigg4	277	72	than	than	IN
cord-002209-xs6qigg4	277	73	is	be	VBZ
cord-002209-xs6qigg4	277	74	survival	survival	NN
cord-002209-xs6qigg4	277	75	of	of	IN
cord-002209-xs6qigg4	277	76	precursors	precursor	NNS
cord-002209-xs6qigg4	277	77	and	and	CC
cord-002209-xs6qigg4	277	78	immature	immature	JJ
cord-002209-xs6qigg4	277	79	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	277	80	Transplantation	transplantation	NN
cord-002209-xs6qigg4	277	81	of	of	IN
cord-002209-xs6qigg4	277	82	ciliary	ciliary	NN
cord-002209-xs6qigg4	277	83	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	277	84	factor	factor	NN
cord-002209-xs6qigg4	277	85	-	-	HYPH
cord-002209-xs6qigg4	277	86	expressing	express	VBG
cord-002209-xs6qigg4	277	87	adult	adult	NN
cord-002209-xs6qigg4	277	88	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	277	89	precursor	precursor	NN
cord-002209-xs6qigg4	277	90	cells	cell	NNS
cord-002209-xs6qigg4	277	91	promotes	promote	VBZ
cord-002209-xs6qigg4	277	92	remyelination	remyelination	NN
cord-002209-xs6qigg4	277	93	and	and	CC
cord-002209-xs6qigg4	277	94	functional	functional	JJ
cord-002209-xs6qigg4	277	95	recovery	recovery	NN
cord-002209-xs6qigg4	277	96	after	after	IN
cord-002209-xs6qigg4	277	97	spinal	spinal	JJ
cord-002209-xs6qigg4	277	98	cord	cord	NN
cord-002209-xs6qigg4	277	99	injury	injury	NN
cord-002209-xs6qigg4	277	100	Induction	Induction	NNP
cord-002209-xs6qigg4	277	101	of	of	IN
cord-002209-xs6qigg4	277	102	the	the	DT
cord-002209-xs6qigg4	277	103	genes	gene	NNS
cord-002209-xs6qigg4	277	104	for	for	IN
cord-002209-xs6qigg4	277	105	Cxcl9	Cxcl9	NNP
cord-002209-xs6qigg4	277	106	and	and	CC
cord-002209-xs6qigg4	277	107	Cxcl10	Cxcl10	NNP
cord-002209-xs6qigg4	277	108	is	be	VBZ
cord-002209-xs6qigg4	277	109	dependent	dependent	JJ
cord-002209-xs6qigg4	277	110	on	on	IN
cord-002209-xs6qigg4	277	111	IFN	IFN	NNP
cord-002209-xs6qigg4	277	112	-	-	HYPH
cord-002209-xs6qigg4	277	113	gamma	gamma	NN
cord-002209-xs6qigg4	277	114	but	but	CC
cord-002209-xs6qigg4	277	115	shows	show	VBZ
cord-002209-xs6qigg4	277	116	differential	differential	JJ
cord-002209-xs6qigg4	277	117	cellular	cellular	JJ
cord-002209-xs6qigg4	277	118	expression	expression	NN
cord-002209-xs6qigg4	277	119	in	in	IN
cord-002209-xs6qigg4	277	120	experimental	experimental	JJ
cord-002209-xs6qigg4	277	121	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	277	122	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	277	123	and	and	CC
cord-002209-xs6qigg4	277	124	by	by	IN
cord-002209-xs6qigg4	277	125	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	277	126	and	and	CC
cord-002209-xs6qigg4	277	127	microglia	microglia	NNS
cord-002209-xs6qigg4	277	128	in	in	IN
cord-002209-xs6qigg4	277	129	vitro	vitro	FW
cord-002209-xs6qigg4	278	1	Thrombospondins	thrombospondin	NNS
cord-002209-xs6qigg4	278	2	are	be	VBP
cord-002209-xs6qigg4	278	3	astrocytesecreted	astrocytesecrete	VBN
cord-002209-xs6qigg4	278	4	proteins	protein	NNS
cord-002209-xs6qigg4	278	5	that	that	WDT
cord-002209-xs6qigg4	278	6	promote	promote	VBP
cord-002209-xs6qigg4	278	7	CNS	CNS	NNP
cord-002209-xs6qigg4	278	8	synaptogenesis	synaptogenesis	NN
cord-002209-xs6qigg4	278	9	Storage	storage	NN
cord-002209-xs6qigg4	278	10	and	and	CC
cord-002209-xs6qigg4	278	11	release	release	NN
cord-002209-xs6qigg4	278	12	of	of	IN
cord-002209-xs6qigg4	278	13	ATP	ATP	NNP
cord-002209-xs6qigg4	278	14	from	from	IN
cord-002209-xs6qigg4	278	15	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	278	16	in	in	IN
cord-002209-xs6qigg4	278	17	culture	culture	NN
cord-002209-xs6qigg4	278	18	CNTF	CNTF	NNP
cord-002209-xs6qigg4	278	19	and	and	CC
cord-002209-xs6qigg4	278	20	CNTF	CNTF	NNP
cord-002209-xs6qigg4	278	21	receptor	receptor	NN
cord-002209-xs6qigg4	278	22	alpha	alpha	NN
cord-002209-xs6qigg4	278	23	are	be	VBP
cord-002209-xs6qigg4	278	24	constitutively	constitutively	RB
cord-002209-xs6qigg4	278	25	expressed	express	VBN
cord-002209-xs6qigg4	278	26	by	by	IN
cord-002209-xs6qigg4	278	27	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	278	28	in	in	IN
cord-002209-xs6qigg4	278	29	the	the	DT
cord-002209-xs6qigg4	278	30	mouse	mouse	NN
cord-002209-xs6qigg4	278	31	brain	brain	NN
cord-002209-xs6qigg4	278	32	Silencing	silence	VBG
cord-002209-xs6qigg4	278	33	IFN	IFN	NNP
cord-002209-xs6qigg4	278	34	-	-	HYPH
cord-002209-xs6qigg4	278	35	γ	γ	NNP
cord-002209-xs6qigg4	278	36	binding	binding	NN
cord-002209-xs6qigg4	278	37	/	/	SYM
cord-002209-xs6qigg4	278	38	signaling	signal	VBG
cord-002209-xs6qigg4	278	39	in	in	IN
cord-002209-xs6qigg4	278	40	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	278	41	versus	versus	IN
cord-002209-xs6qigg4	278	42	microglia	microglia	NN
cord-002209-xs6qigg4	278	43	leads	lead	VBZ
cord-002209-xs6qigg4	278	44	to	to	IN
cord-002209-xs6qigg4	278	45	opposite	opposite	JJ
cord-002209-xs6qigg4	278	46	effects	effect	NNS
cord-002209-xs6qigg4	278	47	on	on	IN
cord-002209-xs6qigg4	278	48	central	central	JJ
cord-002209-xs6qigg4	278	49	nervous	nervous	JJ
cord-002209-xs6qigg4	278	50	system	system	NN
cord-002209-xs6qigg4	278	51	autoimmunity	autoimmunity	NN
cord-002209-xs6qigg4	278	52	Expression	expression	NN
cord-002209-xs6qigg4	278	53	of	of	IN
cord-002209-xs6qigg4	278	54	neurotrophins	neurotrophin	NNS
cord-002209-xs6qigg4	278	55	in	in	IN
cord-002209-xs6qigg4	278	56	the	the	DT
cord-002209-xs6qigg4	278	57	adult	adult	NN
cord-002209-xs6qigg4	278	58	spinal	spinal	JJ
cord-002209-xs6qigg4	278	59	cord	cord	NN
cord-002209-xs6qigg4	278	60	in	in	IN
cord-002209-xs6qigg4	278	61	vivo	vivo	NN
cord-002209-xs6qigg4	279	1	An	an	DT
cord-002209-xs6qigg4	279	2	acidic	acidic	JJ
cord-002209-xs6qigg4	279	3	protein	protein	NN
cord-002209-xs6qigg4	279	4	isolated	isolate	VBN
cord-002209-xs6qigg4	279	5	from	from	IN
cord-002209-xs6qigg4	279	6	fibrous	fibrous	JJ
cord-002209-xs6qigg4	279	7	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	279	8	Expression	expression	NN
cord-002209-xs6qigg4	279	9	of	of	IN
cord-002209-xs6qigg4	279	10	glutamate	glutamate	NN
cord-002209-xs6qigg4	279	11	uptake	uptake	NN
cord-002209-xs6qigg4	279	12	transporters	transporter	NNS
cord-002209-xs6qigg4	279	13	after	after	IN
cord-002209-xs6qigg4	279	14	dibutyryl	dibutyryl	NNP
cord-002209-xs6qigg4	279	15	cyclic	cyclic	JJ
cord-002209-xs6qigg4	279	16	AMP	AMP	NNP
cord-002209-xs6qigg4	279	17	differentiation	differentiation	NN
cord-002209-xs6qigg4	279	18	and	and	CC
cord-002209-xs6qigg4	279	19	traumatic	traumatic	JJ
cord-002209-xs6qigg4	279	20	injury	injury	NN
cord-002209-xs6qigg4	279	21	in	in	IN
cord-002209-xs6qigg4	279	22	cultured	cultured	JJ
cord-002209-xs6qigg4	279	23	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	280	1	The	the	DT
cord-002209-xs6qigg4	280	2	role	role	NN
cord-002209-xs6qigg4	280	3	of	of	IN
cord-002209-xs6qigg4	280	4	excitatory	excitatory	JJ
cord-002209-xs6qigg4	280	5	amino	amino	JJ
cord-002209-xs6qigg4	280	6	acids	acid	NNS
cord-002209-xs6qigg4	280	7	and	and	CC
cord-002209-xs6qigg4	280	8	NMDA	NMDA	NNP
cord-002209-xs6qigg4	280	9	receptors	receptor	NNS
cord-002209-xs6qigg4	280	10	in	in	IN
cord-002209-xs6qigg4	281	1	traumatic	traumatic	JJ
cord-002209-xs6qigg4	281	2	brain	brain	NN
cord-002209-xs6qigg4	281	3	injury	injury	NN
cord-002209-xs6qigg4	281	4	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	281	5	are	be	VBP
cord-002209-xs6qigg4	281	6	active	active	JJ
cord-002209-xs6qigg4	281	7	players	player	NNS
cord-002209-xs6qigg4	281	8	in	in	IN
cord-002209-xs6qigg4	281	9	cerebral	cerebral	JJ
cord-002209-xs6qigg4	281	10	innate	innate	JJ
cord-002209-xs6qigg4	281	11	immunity	immunity	NN
cord-002209-xs6qigg4	281	12	Reactive	reactive	JJ
cord-002209-xs6qigg4	281	13	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	281	14	protect	protect	VBP
cord-002209-xs6qigg4	281	15	tissue	tissue	NN
cord-002209-xs6qigg4	281	16	and	and	CC
cord-002209-xs6qigg4	281	17	preserve	preserve	VB
cord-002209-xs6qigg4	281	18	function	function	NN
cord-002209-xs6qigg4	281	19	after	after	IN
cord-002209-xs6qigg4	281	20	spinal	spinal	JJ
cord-002209-xs6qigg4	281	21	cord	cord	NN
cord-002209-xs6qigg4	281	22	injury	injury	NN
cord-002209-xs6qigg4	281	23	Bovine	bovine	JJ
cord-002209-xs6qigg4	281	24	brain	brain	NN
cord-002209-xs6qigg4	281	25	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	281	26	express	express	VBP
cord-002209-xs6qigg4	281	27	basic	basic	JJ
cord-002209-xs6qigg4	281	28	fibroblast	fibroblast	NN
cord-002209-xs6qigg4	281	29	growth	growth	NN
cord-002209-xs6qigg4	281	30	factor	factor	NN
cord-002209-xs6qigg4	281	31	,	,	,
cord-002209-xs6qigg4	281	32	a	a	DT
cord-002209-xs6qigg4	281	33	neurotropic	neurotropic	NNP
cord-002209-xs6qigg4	281	34	and	and	CC
cord-002209-xs6qigg4	281	35	angiogenic	angiogenic	JJ
cord-002209-xs6qigg4	281	36	mitogen	mitogen	NNP
cord-002209-xs6qigg4	282	1	CXCL10	CXCL10	NNP
cord-002209-xs6qigg4	283	1	(	(	-LRB-
cord-002209-xs6qigg4	283	2	IFN	IFN	NNP
cord-002209-xs6qigg4	283	3	-	-	HYPH
cord-002209-xs6qigg4	283	4	gamma	gamma	NN
cord-002209-xs6qigg4	283	5	-	-	HYPH
cord-002209-xs6qigg4	283	6	inducible	inducible	JJ
cord-002209-xs6qigg4	283	7	protein-10	protein-10	CD
cord-002209-xs6qigg4	283	8	)	)	-RRB-
cord-002209-xs6qigg4	283	9	control	control	NN
cord-002209-xs6qigg4	283	10	of	of	IN
cord-002209-xs6qigg4	283	11	encephalitogenic	encephalitogenic	NNP
cord-002209-xs6qigg4	283	12	CD4	CD4	NNP
cord-002209-xs6qigg4	283	13	+	+	CC
cord-002209-xs6qigg4	283	14	T	T	NNP
cord-002209-xs6qigg4	283	15	cell	cell	NN
cord-002209-xs6qigg4	283	16	accumulation	accumulation	NN
cord-002209-xs6qigg4	283	17	in	in	IN
cord-002209-xs6qigg4	283	18	the	the	DT
cord-002209-xs6qigg4	283	19	central	central	JJ
cord-002209-xs6qigg4	283	20	nervous	nervous	JJ
cord-002209-xs6qigg4	283	21	system	system	NN
cord-002209-xs6qigg4	283	22	during	during	IN
cord-002209-xs6qigg4	283	23	experimental	experimental	JJ
cord-002209-xs6qigg4	283	24	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	283	25	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	283	26	Inhibition	inhibition	NN
cord-002209-xs6qigg4	283	27	of	of	IN
cord-002209-xs6qigg4	283	28	cytokine	cytokine	NN
cord-002209-xs6qigg4	283	29	-	-	HYPH
cord-002209-xs6qigg4	283	30	induced	induce	VBN
cord-002209-xs6qigg4	283	31	connexin43	connexin43	NN
cord-002209-xs6qigg4	283	32	hemichannel	hemichannel	NN
cord-002209-xs6qigg4	283	33	activity	activity	NN
cord-002209-xs6qigg4	283	34	in	in	IN
cord-002209-xs6qigg4	283	35	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	283	36	is	be	VBZ
cord-002209-xs6qigg4	283	37	neuroprotective	neuroprotective	JJ
cord-002209-xs6qigg4	283	38	PDGF	PDGF	NNP
cord-002209-xs6qigg4	283	39	and	and	CC
cord-002209-xs6qigg4	283	40	FGF2	FGF2	NNP
cord-002209-xs6qigg4	284	1	regulate	regulate	VB
cord-002209-xs6qigg4	284	2	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	284	3	progenitor	progenitor	NN
cord-002209-xs6qigg4	284	4	responses	response	NNS
cord-002209-xs6qigg4	284	5	to	to	IN
cord-002209-xs6qigg4	284	6	demyelination	demyelination	NN
cord-002209-xs6qigg4	284	7	Differential	differential	JJ
cord-002209-xs6qigg4	284	8	expressions	expression	NNS
cord-002209-xs6qigg4	284	9	of	of	IN
cord-002209-xs6qigg4	284	10	glycine	glycine	NN
cord-002209-xs6qigg4	284	11	transporter	transporter	NN
cord-002209-xs6qigg4	284	12	1	1	CD
cord-002209-xs6qigg4	284	13	and	and	CC
cord-002209-xs6qigg4	284	14	three	three	CD
cord-002209-xs6qigg4	284	15	glutamate	glutamate	NN
cord-002209-xs6qigg4	284	16	transporter	transporter	NN
cord-002209-xs6qigg4	284	17	mRNA	mrna	NN
cord-002209-xs6qigg4	284	18	in	in	IN
cord-002209-xs6qigg4	284	19	the	the	DT
cord-002209-xs6qigg4	284	20	hippocampus	hippocampus	NN
cord-002209-xs6qigg4	284	21	of	of	IN
cord-002209-xs6qigg4	284	22	gerbils	gerbil	NNS
cord-002209-xs6qigg4	284	23	with	with	IN
cord-002209-xs6qigg4	284	24	transient	transient	JJ
cord-002209-xs6qigg4	284	25	forebrain	forebrain	NN
cord-002209-xs6qigg4	284	26	ischemia	ischemia	NN
cord-002209-xs6qigg4	285	1	Glycolytic	glycolytic	NN
cord-002209-xs6qigg4	285	2	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	285	3	maintain	maintain	VBP
cord-002209-xs6qigg4	285	4	myelin	myelin	JJ
cord-002209-xs6qigg4	285	5	and	and	CC
cord-002209-xs6qigg4	285	6	long	long	JJ
cord-002209-xs6qigg4	285	7	-	-	HYPH
cord-002209-xs6qigg4	285	8	term	term	NN
cord-002209-xs6qigg4	285	9	axonal	axonal	JJ
cord-002209-xs6qigg4	285	10	integrity	integrity	NN
cord-002209-xs6qigg4	285	11	Synchronous	synchronous	JJ
cord-002209-xs6qigg4	285	12	synthesis	synthesis	NN
cord-002209-xs6qigg4	285	13	of	of	IN
cord-002209-xs6qigg4	285	14	alpha	alpha	NN
cord-002209-xs6qigg4	285	15	-	-	HYPH
cord-002209-xs6qigg4	285	16	and	and	CC
cord-002209-xs6qigg4	285	17	beta	beta	NN
cord-002209-xs6qigg4	285	18	-	-	HYPH
cord-002209-xs6qigg4	285	19	chemokines	chemokine	NNS
cord-002209-xs6qigg4	285	20	by	by	IN
cord-002209-xs6qigg4	285	21	cells	cell	NNS
cord-002209-xs6qigg4	285	22	of	of	IN
cord-002209-xs6qigg4	285	23	diverse	diverse	JJ
cord-002209-xs6qigg4	285	24	lineage	lineage	NN
cord-002209-xs6qigg4	285	25	in	in	IN
cord-002209-xs6qigg4	285	26	the	the	DT
cord-002209-xs6qigg4	285	27	central	central	JJ
cord-002209-xs6qigg4	285	28	nervous	nervous	JJ
cord-002209-xs6qigg4	285	29	system	system	NN
cord-002209-xs6qigg4	285	30	of	of	IN
cord-002209-xs6qigg4	285	31	mice	mouse	NNS
cord-002209-xs6qigg4	285	32	with	with	IN
cord-002209-xs6qigg4	285	33	relapses	relapse	NNS
cord-002209-xs6qigg4	285	34	of	of	IN
cord-002209-xs6qigg4	285	35	chronic	chronic	JJ
cord-002209-xs6qigg4	285	36	experimental	experimental	JJ
cord-002209-xs6qigg4	285	37	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	285	38	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	285	39	Chemokine	chemokine	JJ
cord-002209-xs6qigg4	285	40	expression	expression	NN
cord-002209-xs6qigg4	285	41	in	in	IN
cord-002209-xs6qigg4	285	42	murine	murine	JJ
cord-002209-xs6qigg4	285	43	experimental	experimental	JJ
cord-002209-xs6qigg4	285	44	allergic	allergic	JJ
cord-002209-xs6qigg4	285	45	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	285	46	Selective	selective	JJ
cord-002209-xs6qigg4	285	47	excitatory	excitatory	JJ
cord-002209-xs6qigg4	285	48	amino	amino	NN
cord-002209-xs6qigg4	285	49	acid	acid	NN
cord-002209-xs6qigg4	285	50	uptake	uptake	NN
cord-002209-xs6qigg4	285	51	in	in	IN
cord-002209-xs6qigg4	285	52	glutamatergic	glutamatergic	JJ
cord-002209-xs6qigg4	285	53	nerve	nerve	NN
cord-002209-xs6qigg4	285	54	terminals	terminal	NNS
cord-002209-xs6qigg4	285	55	and	and	CC
cord-002209-xs6qigg4	285	56	in	in	IN
cord-002209-xs6qigg4	285	57	glia	glia	NNS
cord-002209-xs6qigg4	285	58	in	in	IN
cord-002209-xs6qigg4	285	59	the	the	DT
cord-002209-xs6qigg4	285	60	rat	rat	NN
cord-002209-xs6qigg4	285	61	striatum	striatum	NN
cord-002209-xs6qigg4	285	62	:	:	:
cord-002209-xs6qigg4	285	63	quantitative	quantitative	JJ
cord-002209-xs6qigg4	285	64	electron	electron	NN
cord-002209-xs6qigg4	285	65	microscopic	microscopic	JJ
cord-002209-xs6qigg4	285	66	immunocytochemistry	immunocytochemistry	NN
cord-002209-xs6qigg4	285	67	of	of	IN
cord-002209-xs6qigg4	285	68	exogenous	exogenous	JJ
cord-002209-xs6qigg4	285	69	(	(	-LRB-
cord-002209-xs6qigg4	285	70	D)-aspartate	D)-aspartate	NNP
cord-002209-xs6qigg4	285	71	and	and	CC
cord-002209-xs6qigg4	285	72	endogenous	endogenous	JJ
cord-002209-xs6qigg4	285	73	glutamate	glutamate	NN
cord-002209-xs6qigg4	285	74	and	and	CC
cord-002209-xs6qigg4	285	75	GABA	GABA	NNP
cord-002209-xs6qigg4	285	76	Astroglial	Astroglial	NNP
cord-002209-xs6qigg4	285	77	ciliary	ciliary	NN
cord-002209-xs6qigg4	285	78	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	285	79	factor	factor	NN
cord-002209-xs6qigg4	286	1	mRNA	mRNA	NNP
cord-002209-xs6qigg4	286	2	expression	expression	NN
cord-002209-xs6qigg4	286	3	is	be	VBZ
cord-002209-xs6qigg4	286	4	increased	increase	VBN
cord-002209-xs6qigg4	286	5	in	in	IN
cord-002209-xs6qigg4	286	6	fields	field	NNS
cord-002209-xs6qigg4	286	7	of	of	IN
cord-002209-xs6qigg4	286	8	axonal	axonal	JJ
cord-002209-xs6qigg4	286	9	sprouting	sprout	VBG
cord-002209-xs6qigg4	286	10	in	in	IN
cord-002209-xs6qigg4	286	11	deafferented	deafferente	VBN
cord-002209-xs6qigg4	286	12	hippocampus	hippocampus	NN
cord-002209-xs6qigg4	287	1	The	the	DT
cord-002209-xs6qigg4	287	2	tripartite	tripartite	JJ
cord-002209-xs6qigg4	287	3	synapse	synapse	NN
cord-002209-xs6qigg4	287	4	:	:	:
cord-002209-xs6qigg4	287	5	roles	role	NNS
cord-002209-xs6qigg4	287	6	for	for	IN
cord-002209-xs6qigg4	287	7	gliotransmission	gliotransmission	NN
cord-002209-xs6qigg4	287	8	in	in	IN
cord-002209-xs6qigg4	287	9	health	health	NN
cord-002209-xs6qigg4	287	10	and	and	CC
cord-002209-xs6qigg4	287	11	disease	disease	NNP
cord-002209-xs6qigg4	287	12	Gp130-dependent	Gp130-dependent	NNP
cord-002209-xs6qigg4	287	13	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	287	14	survival	survival	NN
cord-002209-xs6qigg4	287	15	is	be	VBZ
cord-002209-xs6qigg4	287	16	critical	critical	JJ
cord-002209-xs6qigg4	287	17	for	for	IN
cord-002209-xs6qigg4	287	18	the	the	DT
cord-002209-xs6qigg4	287	19	control	control	NN
cord-002209-xs6qigg4	287	20	of	of	IN
cord-002209-xs6qigg4	287	21	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	287	22	central	central	JJ
cord-002209-xs6qigg4	287	23	nervous	nervous	JJ
cord-002209-xs6qigg4	287	24	system	system	NN
cord-002209-xs6qigg4	287	25	inflammation	inflammation	NN
cord-002209-xs6qigg4	288	1	Interferon	interferon	NN
cord-002209-xs6qigg4	288	2	-	-	HYPH
cord-002209-xs6qigg4	288	3	gamma	gamma	NN
cord-002209-xs6qigg4	288	4	-	-	HYPH
cord-002209-xs6qigg4	288	5	dependent	dependent	JJ
cord-002209-xs6qigg4	288	6	cytotoxic	cytotoxic	JJ
cord-002209-xs6qigg4	288	7	activation	activation	NN
cord-002209-xs6qigg4	288	8	of	of	IN
cord-002209-xs6qigg4	288	9	human	human	JJ
cord-002209-xs6qigg4	288	10	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	288	11	and	and	CC
cord-002209-xs6qigg4	288	12	astrocytoma	astrocytoma	NN
cord-002209-xs6qigg4	288	13	cells	cell	NNS
cord-002209-xs6qigg4	289	1	STAT3	STAT3	NNP
cord-002209-xs6qigg4	289	2	is	be	VBZ
cord-002209-xs6qigg4	289	3	a	a	DT
cord-002209-xs6qigg4	289	4	critical	critical	JJ
cord-002209-xs6qigg4	289	5	regulator	regulator	NN
cord-002209-xs6qigg4	289	6	of	of	IN
cord-002209-xs6qigg4	289	7	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	289	8	and	and	CC
cord-002209-xs6qigg4	289	9	scar	scar	NN
cord-002209-xs6qigg4	289	10	formation	formation	NN
cord-002209-xs6qigg4	289	11	after	after	IN
cord-002209-xs6qigg4	289	12	spinal	spinal	JJ
cord-002209-xs6qigg4	289	13	cord	cord	NN
cord-002209-xs6qigg4	289	14	injury	injury	NN
cord-002209-xs6qigg4	289	15	Central	central	JJ
cord-002209-xs6qigg4	289	16	nervous	nervous	JJ
cord-002209-xs6qigg4	289	17	system	system	NN
cord-002209-xs6qigg4	289	18	-	-	HYPH
cord-002209-xs6qigg4	289	19	initiated	initiate	VBN
cord-002209-xs6qigg4	289	20	inflammation	inflammation	NN
cord-002209-xs6qigg4	289	21	and	and	CC
cord-002209-xs6qigg4	289	22	neurotrophism	neurotrophism	NN
cord-002209-xs6qigg4	289	23	in	in	IN
cord-002209-xs6qigg4	289	24	trauma	trauma	NN
cord-002209-xs6qigg4	289	25	:	:	:
cord-002209-xs6qigg4	290	1	IL-1	IL-1	NNP
cord-002209-xs6qigg4	291	1	beta	beta	NN
cord-002209-xs6qigg4	291	2	is	be	VBZ
cord-002209-xs6qigg4	291	3	required	require	VBN
cord-002209-xs6qigg4	291	4	for	for	IN
cord-002209-xs6qigg4	291	5	the	the	DT
cord-002209-xs6qigg4	291	6	production	production	NN
cord-002209-xs6qigg4	291	7	of	of	IN
cord-002209-xs6qigg4	291	8	ciliary	ciliary	NN
cord-002209-xs6qigg4	291	9	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	291	10	factor	factor	NN
cord-002209-xs6qigg4	291	11	IFN	IFN	NNP
cord-002209-xs6qigg4	291	12	-	-	HYPH
cord-002209-xs6qigg4	291	13	γ	γ	NNP
cord-002209-xs6qigg4	291	14	signaling	signal	VBG
cord-002209-xs6qigg4	291	15	to	to	IN
cord-002209-xs6qigg4	291	16	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	291	17	protects	protect	VBZ
cord-002209-xs6qigg4	291	18	from	from	IN
cord-002209-xs6qigg4	291	19	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	291	20	mediated	mediate	VBN
cord-002209-xs6qigg4	291	21	neurological	neurological	JJ
cord-002209-xs6qigg4	291	22	disability	disability	NN
cord-002209-xs6qigg4	291	23	Adapting	adapt	VBG
cord-002209-xs6qigg4	291	24	brain	brain	NN
cord-002209-xs6qigg4	291	25	metabolism	metabolism	NN
cord-002209-xs6qigg4	291	26	to	to	IN
cord-002209-xs6qigg4	291	27	myelination	myelination	NN
cord-002209-xs6qigg4	291	28	and	and	CC
cord-002209-xs6qigg4	291	29	long	long	JJ
cord-002209-xs6qigg4	291	30	-	-	HYPH
cord-002209-xs6qigg4	291	31	range	range	NN
cord-002209-xs6qigg4	291	32	signal	signal	NN
cord-002209-xs6qigg4	291	33	transduction	transduction	NN
cord-002209-xs6qigg4	291	34	Tumor	tumor	NN
cord-002209-xs6qigg4	291	35	necrosis	necrosis	NN
cord-002209-xs6qigg4	291	36	factor	factor	NN
cord-002209-xs6qigg4	291	37	identified	identify	VBN
cord-002209-xs6qigg4	291	38	in	in	IN
cord-002209-xs6qigg4	291	39	multiple	multiple	JJ
cord-002209-xs6qigg4	291	40	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	291	41	brain	brain	NN
cord-002209-xs6qigg4	291	42	Ciliary	Ciliary	NNP
cord-002209-xs6qigg4	291	43	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	291	44	factor	factor	NN
cord-002209-xs6qigg4	292	1	stimulates	stimulate	VBZ
cord-002209-xs6qigg4	292	2	astroglial	astroglial	JJ
cord-002209-xs6qigg4	292	3	hypertrophy	hypertrophy	NN
cord-002209-xs6qigg4	292	4	in	in	IN
cord-002209-xs6qigg4	292	5	vivo	vivo	NN
cord-002209-xs6qigg4	292	6	and	and	CC
cord-002209-xs6qigg4	292	7	in	in	IN
cord-002209-xs6qigg4	292	8	vitro	vitro	FW
cord-002209-xs6qigg4	292	9	Cultured	cultured	JJ
cord-002209-xs6qigg4	292	10	adult	adult	NN
cord-002209-xs6qigg4	292	11	porcine	porcine	JJ
cord-002209-xs6qigg4	292	12	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	292	13	and	and	CC
cord-002209-xs6qigg4	292	14	microglia	microglia	NNP
cord-002209-xs6qigg4	293	1	express	express	VB
cord-002209-xs6qigg4	293	2	functional	functional	JJ
cord-002209-xs6qigg4	293	3	interferon	interferon	NN
cord-002209-xs6qigg4	293	4	-	-	HYPH
cord-002209-xs6qigg4	293	5	γ	γ	NN
cord-002209-xs6qigg4	293	6	receptors	receptor	NNS
cord-002209-xs6qigg4	293	7	and	and	CC
cord-002209-xs6qigg4	293	8	exhibit	exhibit	VBP
cord-002209-xs6qigg4	293	9	toxicity	toxicity	NN
cord-002209-xs6qigg4	293	10	towards	towards	IN
cord-002209-xs6qigg4	293	11	SH	sh	NN
cord-002209-xs6qigg4	293	12	-	-	HYPH
cord-002209-xs6qigg4	293	13	SY5Y	sy5y	NN
cord-002209-xs6qigg4	293	14	cells	cell	NNS
cord-002209-xs6qigg4	294	1	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	294	2	promote	promote	VBP
cord-002209-xs6qigg4	294	3	myelination	myelination	NN
cord-002209-xs6qigg4	294	4	in	in	IN
cord-002209-xs6qigg4	294	5	response	response	NN
cord-002209-xs6qigg4	294	6	to	to	IN
cord-002209-xs6qigg4	294	7	electrical	electrical	JJ
cord-002209-xs6qigg4	294	8	impulses	impulse	NNS
cord-002209-xs6qigg4	294	9	Brain	Brain	NNP
cord-002209-xs6qigg4	294	10	parenchymal	parenchymal	NN
cord-002209-xs6qigg4	294	11	TNF	TNF	NNP
cord-002209-xs6qigg4	294	12	-	-	HYPH
cord-002209-xs6qigg4	294	13	α	α	NNP
cord-002209-xs6qigg4	294	14	and	and	CC
cord-002209-xs6qigg4	294	15	IL-1β	il-1β	NN
cord-002209-xs6qigg4	294	16	induction	induction	NN
cord-002209-xs6qigg4	294	17	in	in	IN
cord-002209-xs6qigg4	294	18	experimental	experimental	JJ
cord-002209-xs6qigg4	294	19	pneumococcal	pneumococcal	JJ
cord-002209-xs6qigg4	294	20	meningitis	meningitis	NN
cord-002209-xs6qigg4	294	21	Microglia	Microglia	NNP
cord-002209-xs6qigg4	294	22	:	:	:
cord-002209-xs6qigg4	294	23	an	an	DT
cord-002209-xs6qigg4	294	24	active	active	JJ
cord-002209-xs6qigg4	294	25	player	player	NN
cord-002209-xs6qigg4	294	26	in	in	IN
cord-002209-xs6qigg4	294	27	the	the	DT
cord-002209-xs6qigg4	294	28	regulation	regulation	NN
cord-002209-xs6qigg4	294	29	of	of	IN
cord-002209-xs6qigg4	294	30	synaptic	synaptic	JJ
cord-002209-xs6qigg4	294	31	activity	activity	NN
cord-002209-xs6qigg4	294	32	Cytokines	Cytokines	NNPS
cord-002209-xs6qigg4	294	33	:	:	:
cord-002209-xs6qigg4	294	34	powerful	powerful	JJ
cord-002209-xs6qigg4	294	35	regulators	regulator	NNS
cord-002209-xs6qigg4	294	36	of	of	IN
cord-002209-xs6qigg4	294	37	glial	glial	JJ
cord-002209-xs6qigg4	294	38	cell	cell	NN
cord-002209-xs6qigg4	294	39	activation	activation	NN
cord-002209-xs6qigg4	294	40	Expression	expression	NN
cord-002209-xs6qigg4	294	41	of	of	IN
cord-002209-xs6qigg4	294	42	viral	viral	JJ
cord-002209-xs6qigg4	294	43	and	and	CC
cord-002209-xs6qigg4	294	44	myelin	myelin	JJ
cord-002209-xs6qigg4	294	45	gene	gene	NN
cord-002209-xs6qigg4	294	46	transcripts	transcript	NNS
cord-002209-xs6qigg4	294	47	in	in	IN
cord-002209-xs6qigg4	294	48	a	a	DT
cord-002209-xs6qigg4	294	49	murine	murine	JJ
cord-002209-xs6qigg4	294	50	CNS	CNS	NNP
cord-002209-xs6qigg4	294	51	demyelinating	demyelinate	VBG
cord-002209-xs6qigg4	294	52	disease	disease	NN
cord-002209-xs6qigg4	294	53	caused	cause	VBN
cord-002209-xs6qigg4	294	54	by	by	IN
cord-002209-xs6qigg4	294	55	a	a	DT
cord-002209-xs6qigg4	294	56	coronavirus	coronavirus	NN
cord-002209-xs6qigg4	294	57	GFAP	GFAP	NNP
cord-002209-xs6qigg4	294	58	isoforms	isoform	NNS
cord-002209-xs6qigg4	294	59	in	in	IN
cord-002209-xs6qigg4	294	60	adult	adult	NN
cord-002209-xs6qigg4	294	61	mouse	mouse	NN
cord-002209-xs6qigg4	294	62	brain	brain	NN
cord-002209-xs6qigg4	294	63	with	with	IN
cord-002209-xs6qigg4	294	64	a	a	DT
cord-002209-xs6qigg4	294	65	focus	focus	NN
cord-002209-xs6qigg4	294	66	on	on	IN
cord-002209-xs6qigg4	294	67	neurogenic	neurogenic	JJ
cord-002209-xs6qigg4	294	68	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	294	69	and	and	CC
cord-002209-xs6qigg4	294	70	reactive	reactive	JJ
cord-002209-xs6qigg4	294	71	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	294	72	in	in	IN
cord-002209-xs6qigg4	294	73	mouse	mouse	NN
cord-002209-xs6qigg4	294	74	models	model	NNS
cord-002209-xs6qigg4	294	75	of	of	IN
cord-002209-xs6qigg4	294	76	Alzheimer	Alzheimer	NNP
cord-002209-xs6qigg4	294	77	disease	disease	NN
cord-002209-xs6qigg4	294	78	Neuroinflammation	Neuroinflammation	NNP
cord-002209-xs6qigg4	295	1	leads	lead	VBZ
cord-002209-xs6qigg4	295	2	to	to	IN
cord-002209-xs6qigg4	295	3	region	region	NN
cord-002209-xs6qigg4	295	4	-	-	HYPH
cord-002209-xs6qigg4	295	5	dependent	dependent	JJ
cord-002209-xs6qigg4	295	6	alterations	alteration	NNS
cord-002209-xs6qigg4	295	7	in	in	IN
cord-002209-xs6qigg4	295	8	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	295	9	gap	gap	NN
cord-002209-xs6qigg4	295	10	junction	junction	NN
cord-002209-xs6qigg4	295	11	communication	communication	NN
cord-002209-xs6qigg4	295	12	and	and	CC
cord-002209-xs6qigg4	295	13	hemichannel	hemichannel	NN
cord-002209-xs6qigg4	295	14	activity	activity	NN
cord-002209-xs6qigg4	295	15	Regulation	Regulation	NNP
cord-002209-xs6qigg4	295	16	of	of	IN
cord-002209-xs6qigg4	295	17	an	an	DT
cord-002209-xs6qigg4	295	18	oligodendrocyte	oligodendrocyte	JJ
cord-002209-xs6qigg4	295	19	progenitor	progenitor	JJ
cord-002209-xs6qigg4	295	20	cell	cell	NN
cord-002209-xs6qigg4	295	21	line	line	NN
cord-002209-xs6qigg4	295	22	by	by	IN
cord-002209-xs6qigg4	295	23	the	the	DT
cord-002209-xs6qigg4	295	24	interleukin-6	interleukin-6	NNP
cord-002209-xs6qigg4	295	25	family	family	NN
cord-002209-xs6qigg4	295	26	of	of	IN
cord-002209-xs6qigg4	295	27	cytokines	cytokine	NNS
cord-002209-xs6qigg4	295	28	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	296	1	promote	promote	VB
cord-002209-xs6qigg4	296	2	TNF	TNF	NNP
cord-002209-xs6qigg4	296	3	-	-	HYPH
cord-002209-xs6qigg4	296	4	mediated	mediate	VBN
cord-002209-xs6qigg4	296	5	toxicity	toxicity	NN
cord-002209-xs6qigg4	296	6	to	to	IN
cord-002209-xs6qigg4	296	7	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	296	8	precursors	precursor	NNS
cord-002209-xs6qigg4	296	9	Neurons	Neurons	NNPS
cord-002209-xs6qigg4	296	10	control	control	VBP
cord-002209-xs6qigg4	296	11	the	the	DT
cord-002209-xs6qigg4	296	12	expression	expression	NN
cord-002209-xs6qigg4	296	13	of	of	IN
cord-002209-xs6qigg4	296	14	connexin	connexin	NNP
cord-002209-xs6qigg4	296	15	30	30	CD
cord-002209-xs6qigg4	296	16	and	and	CC
cord-002209-xs6qigg4	296	17	connexin	connexin	NNP
cord-002209-xs6qigg4	296	18	43	43	CD
cord-002209-xs6qigg4	296	19	in	in	IN
cord-002209-xs6qigg4	296	20	mouse	mouse	NN
cord-002209-xs6qigg4	296	21	cortical	cortical	JJ
cord-002209-xs6qigg4	296	22	astrocytes	astrocyte	VBZ
cord-002209-xs6qigg4	296	23	Changes	change	NNS
cord-002209-xs6qigg4	296	24	in	in	IN
cord-002209-xs6qigg4	296	25	astroglial	astroglial	JJ
cord-002209-xs6qigg4	296	26	GLT-1	GLT-1	NNP
cord-002209-xs6qigg4	296	27	expression	expression	NN
cord-002209-xs6qigg4	296	28	after	after	IN
cord-002209-xs6qigg4	296	29	neural	neural	JJ
cord-002209-xs6qigg4	296	30	transplantation	transplantation	NN
cord-002209-xs6qigg4	296	31	or	or	CC
cord-002209-xs6qigg4	296	32	stab	stab	NN
cord-002209-xs6qigg4	296	33	wounds	wound	NNS
cord-002209-xs6qigg4	297	1	Synchronous	synchronous	JJ
cord-002209-xs6qigg4	297	2	hyperactivity	hyperactivity	NN
cord-002209-xs6qigg4	297	3	and	and	CC
cord-002209-xs6qigg4	297	4	intercellular	intercellular	JJ
cord-002209-xs6qigg4	297	5	calcium	calcium	NN
cord-002209-xs6qigg4	297	6	waves	wave	NNS
cord-002209-xs6qigg4	297	7	in	in	IN
cord-002209-xs6qigg4	297	8	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	297	9	in	in	IN
cord-002209-xs6qigg4	297	10	Alzheimer	Alzheimer	NNP
cord-002209-xs6qigg4	297	11	mice	mouse	NNS
cord-002209-xs6qigg4	298	1	Continued	continued	JJ
cord-002209-xs6qigg4	298	2	administration	administration	NN
cord-002209-xs6qigg4	298	3	of	of	IN
cord-002209-xs6qigg4	298	4	ciliary	ciliary	NNP
cord-002209-xs6qigg4	298	5	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	298	6	factor	factor	NN
cord-002209-xs6qigg4	298	7	protects	protect	VBZ
cord-002209-xs6qigg4	298	8	mice	mouse	NNS
cord-002209-xs6qigg4	298	9	from	from	IN
cord-002209-xs6qigg4	298	10	inflammatory	inflammatory	JJ
cord-002209-xs6qigg4	298	11	pathology	pathology	NN
cord-002209-xs6qigg4	298	12	in	in	IN
cord-002209-xs6qigg4	298	13	experimental	experimental	JJ
cord-002209-xs6qigg4	298	14	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	298	15	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	298	16	Stage	stage	NN
cord-002209-xs6qigg4	298	17	-	-	HYPH
cord-002209-xs6qigg4	298	18	specific	specific	JJ
cord-002209-xs6qigg4	298	19	association	association	NN
cord-002209-xs6qigg4	298	20	of	of	IN
cord-002209-xs6qigg4	298	21	apolipoprotein	apolipoprotein	NNP
cord-002209-xs6qigg4	298	22	A	A	NNP
cord-002209-xs6qigg4	298	23	-	-	:
cord-002209-xs6qigg4	298	24	I	i	NN
cord-002209-xs6qigg4	298	25	and	and	CC
cord-002209-xs6qigg4	298	26	E	e	NN
cord-002209-xs6qigg4	298	27	in	in	IN
cord-002209-xs6qigg4	298	28	developing	develop	VBG
cord-002209-xs6qigg4	298	29	mouse	mouse	NN
cord-002209-xs6qigg4	298	30	retina	retina	JJ
cord-002209-xs6qigg4	298	31	Regional	regional	JJ
cord-002209-xs6qigg4	298	32	hypomyelination	hypomyelination	NN
cord-002209-xs6qigg4	298	33	and	and	CC
cord-002209-xs6qigg4	298	34	dysplasia	dysplasia	NN
cord-002209-xs6qigg4	298	35	in	in	IN
cord-002209-xs6qigg4	298	36	transgenic	transgenic	JJ
cord-002209-xs6qigg4	298	37	mice	mouse	NNS
cord-002209-xs6qigg4	298	38	with	with	IN
cord-002209-xs6qigg4	298	39	astrocyte	astrocyte	RB
cord-002209-xs6qigg4	298	40	-	-	HYPH
cord-002209-xs6qigg4	298	41	directed	direct	VBN
cord-002209-xs6qigg4	298	42	expression	expression	NN
cord-002209-xs6qigg4	298	43	of	of	IN
cord-002209-xs6qigg4	298	44	interferongamma	interferongamma	NNP
cord-002209-xs6qigg4	298	45	Acute	Acute	NNP
cord-002209-xs6qigg4	298	46	exposure	exposure	NN
cord-002209-xs6qigg4	298	47	to	to	IN
cord-002209-xs6qigg4	298	48	CNTF	CNTF	NNP
cord-002209-xs6qigg4	298	49	in	in	IN
cord-002209-xs6qigg4	298	50	vivo	vivo	NNP
cord-002209-xs6qigg4	298	51	induces	induce	VBZ
cord-002209-xs6qigg4	298	52	multiple	multiple	JJ
cord-002209-xs6qigg4	298	53	components	component	NNS
cord-002209-xs6qigg4	298	54	of	of	IN
cord-002209-xs6qigg4	298	55	reactive	reactive	JJ
cord-002209-xs6qigg4	298	56	gliosis	gliosis	NN
cord-002209-xs6qigg4	298	57	Ciliary	Ciliary	NNP
cord-002209-xs6qigg4	298	58	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	298	59	factor	factor	NN
cord-002209-xs6qigg4	298	60	stimulates	stimulate	VBZ
cord-002209-xs6qigg4	298	61	nuclear	nuclear	JJ
cord-002209-xs6qigg4	298	62	hypertrophy	hypertrophy	NN
cord-002209-xs6qigg4	298	63	and	and	CC
cord-002209-xs6qigg4	298	64	increases	increase	VBZ
cord-002209-xs6qigg4	298	65	the	the	DT
cord-002209-xs6qigg4	298	66	GFAP	GFAP	NNP
cord-002209-xs6qigg4	298	67	content	content	NN
cord-002209-xs6qigg4	298	68	of	of	IN
cord-002209-xs6qigg4	298	69	cultured	cultured	JJ
cord-002209-xs6qigg4	298	70	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	298	71	GFAP	GFAP	NNP
cord-002209-xs6qigg4	298	72	mutations	mutation	NNS
cord-002209-xs6qigg4	298	73	in	in	IN
cord-002209-xs6qigg4	298	74	Alexander	Alexander	NNP
cord-002209-xs6qigg4	298	75	disease	disease	NN
cord-002209-xs6qigg4	298	76	Pro	pro	JJ
cord-002209-xs6qigg4	298	77	-	-	JJ
cord-002209-xs6qigg4	298	78	regenerative	regenerative	JJ
cord-002209-xs6qigg4	298	79	properties	property	NNS
cord-002209-xs6qigg4	298	80	of	of	IN
cord-002209-xs6qigg4	298	81	cytokine	cytokine	NN
cord-002209-xs6qigg4	298	82	-	-	HYPH
cord-002209-xs6qigg4	298	83	activated	activate	VBN
cord-002209-xs6qigg4	298	84	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	298	85	GFAP	GFAP	NNP
cord-002209-xs6qigg4	298	86	is	be	VBZ
cord-002209-xs6qigg4	298	87	necessary	necessary	JJ
cord-002209-xs6qigg4	298	88	for	for	IN
cord-002209-xs6qigg4	298	89	the	the	DT
cord-002209-xs6qigg4	298	90	integrity	integrity	NN
cord-002209-xs6qigg4	298	91	of	of	IN
cord-002209-xs6qigg4	298	92	CNS	CNS	NNP
cord-002209-xs6qigg4	298	93	white	white	JJ
cord-002209-xs6qigg4	298	94	matter	matter	NN
cord-002209-xs6qigg4	298	95	architecture	architecture	NN
cord-002209-xs6qigg4	298	96	and	and	CC
cord-002209-xs6qigg4	298	97	long	long	JJ
cord-002209-xs6qigg4	298	98	-	-	HYPH
cord-002209-xs6qigg4	298	99	term	term	NN
cord-002209-xs6qigg4	298	100	maintenance	maintenance	NN
cord-002209-xs6qigg4	298	101	of	of	IN
cord-002209-xs6qigg4	298	102	myelination	myelination	NN
cord-002209-xs6qigg4	299	1	Immunoreactive	immunoreactive	JJ
cord-002209-xs6qigg4	299	2	apolipoprotein	apolipoprotein	NN
cord-002209-xs6qigg4	299	3	E	e	NN
cord-002209-xs6qigg4	299	4	is	be	VBZ
cord-002209-xs6qigg4	299	5	a	a	DT
cord-002209-xs6qigg4	299	6	widely	widely	RB
cord-002209-xs6qigg4	299	7	distributed	distribute	VBN
cord-002209-xs6qigg4	299	8	cellular	cellular	JJ
cord-002209-xs6qigg4	299	9	protein	protein	NN
cord-002209-xs6qigg4	299	10	.	.	.
cord-002209-xs6qigg4	300	1	Immunohistochemical	immunohistochemical	JJ
cord-002209-xs6qigg4	300	2	localization	localization	NN
cord-002209-xs6qigg4	300	3	of	of	IN
cord-002209-xs6qigg4	300	4	apolipoprotein	apolipoprotein	NN
cord-002209-xs6qigg4	300	5	E	e	NN
cord-002209-xs6qigg4	300	6	in	in	IN
cord-002209-xs6qigg4	300	7	baboon	baboon	NN
cord-002209-xs6qigg4	300	8	tissues	tissue	NNS
cord-002209-xs6qigg4	301	1	Interferon	interferon	NN
cord-002209-xs6qigg4	301	2	-	-	HYPH
cord-002209-xs6qigg4	301	3	gamma	gamma	NN
cord-002209-xs6qigg4	301	4	inhibits	inhibit	VBZ
cord-002209-xs6qigg4	301	5	central	central	JJ
cord-002209-xs6qigg4	301	6	nervous	nervous	JJ
cord-002209-xs6qigg4	301	7	system	system	NN
cord-002209-xs6qigg4	301	8	remyelination	remyelination	NN
cord-002209-xs6qigg4	301	9	through	through	IN
cord-002209-xs6qigg4	301	10	a	a	DT
cord-002209-xs6qigg4	301	11	process	process	NN
cord-002209-xs6qigg4	301	12	modulated	modulate	VBN
cord-002209-xs6qigg4	301	13	by	by	IN
cord-002209-xs6qigg4	301	14	endoplasmic	endoplasmic	NN
cord-002209-xs6qigg4	301	15	reticulum	reticulum	NN
cord-002209-xs6qigg4	302	1	stress	stress	NN
cord-002209-xs6qigg4	302	2	CNTF	CNTF	NNP
cord-002209-xs6qigg4	302	3	is	be	VBZ
cord-002209-xs6qigg4	302	4	a	a	DT
cord-002209-xs6qigg4	302	5	major	major	JJ
cord-002209-xs6qigg4	302	6	protective	protective	JJ
cord-002209-xs6qigg4	302	7	factor	factor	NN
cord-002209-xs6qigg4	302	8	in	in	IN
cord-002209-xs6qigg4	302	9	demyelinating	demyelinate	VBG
cord-002209-xs6qigg4	302	10	CNS	CNS	NNP
cord-002209-xs6qigg4	302	11	disease	disease	NN
cord-002209-xs6qigg4	302	12	:	:	:
cord-002209-xs6qigg4	302	13	a	a	DT
cord-002209-xs6qigg4	302	14	neurotrophic	neurotrophic	JJ
cord-002209-xs6qigg4	302	15	cytokine	cytokine	NN
cord-002209-xs6qigg4	302	16	as	as	IN
cord-002209-xs6qigg4	302	17	modulator	modulator	NN
cord-002209-xs6qigg4	302	18	in	in	IN
cord-002209-xs6qigg4	302	19	neuroinflammation	neuroinflammation	NN
cord-002209-xs6qigg4	303	1	Cholesterol	cholesterol	NN
cord-002209-xs6qigg4	303	2	involvement	involvement	NN
cord-002209-xs6qigg4	303	3	in	in	IN
cord-002209-xs6qigg4	303	4	the	the	DT
cord-002209-xs6qigg4	303	5	pathogenesis	pathogenesis	NN
cord-002209-xs6qigg4	303	6	of	of	IN
cord-002209-xs6qigg4	303	7	neurodegenerative	neurodegenerative	JJ
cord-002209-xs6qigg4	303	8	diseases	disease	NNS
cord-002209-xs6qigg4	303	9	Overexpression	Overexpression	NNP
cord-002209-xs6qigg4	303	10	of	of	IN
cord-002209-xs6qigg4	303	11	CNTF	CNTF	NNP
cord-002209-xs6qigg4	303	12	in	in	IN
cord-002209-xs6qigg4	303	13	mesenchymal	mesenchymal	JJ
cord-002209-xs6qigg4	303	14	stem	stem	NN
cord-002209-xs6qigg4	303	15	cells	cell	NNS
cord-002209-xs6qigg4	303	16	reduces	reduce	VBZ
cord-002209-xs6qigg4	303	17	demyelination	demyelination	NN
cord-002209-xs6qigg4	303	18	and	and	CC
cord-002209-xs6qigg4	303	19	induces	induce	VBZ
cord-002209-xs6qigg4	303	20	clinical	clinical	JJ
cord-002209-xs6qigg4	303	21	recovery	recovery	NN
cord-002209-xs6qigg4	303	22	in	in	IN
cord-002209-xs6qigg4	303	23	experimental	experimental	JJ
cord-002209-xs6qigg4	303	24	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	303	25	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	304	1	mice	mouse	NNS
cord-002209-xs6qigg4	304	2	Deletion	Deletion	NNP
cord-002209-xs6qigg4	304	3	of	of	IN
cord-002209-xs6qigg4	304	4	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	304	5	connexins	connexins	NNP
cord-002209-xs6qigg4	304	6	43	43	CD
cord-002209-xs6qigg4	304	7	and	and	CC
cord-002209-xs6qigg4	304	8	30	30	CD
cord-002209-xs6qigg4	304	9	leads	lead	VBZ
cord-002209-xs6qigg4	304	10	to	to	IN
cord-002209-xs6qigg4	304	11	a	a	DT
cord-002209-xs6qigg4	304	12	dysmyelinating	dysmyelinate	VBG
cord-002209-xs6qigg4	304	13	phenotype	phenotype	NN
cord-002209-xs6qigg4	304	14	and	and	CC
cord-002209-xs6qigg4	304	15	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	304	16	CA1	CA1	NNP
cord-002209-xs6qigg4	304	17	vacuolation	vacuolation	NNP
cord-002209-xs6qigg4	304	18	Disruption	Disruption	NNP
cord-002209-xs6qigg4	304	19	of	of	IN
cord-002209-xs6qigg4	304	20	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	304	21	gap	gap	NN
cord-002209-xs6qigg4	304	22	junctions	junction	NNS
cord-002209-xs6qigg4	304	23	in	in	IN
cord-002209-xs6qigg4	304	24	experimental	experimental	JJ
cord-002209-xs6qigg4	304	25	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	304	26	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	304	27	Neuronal	neuronal	JJ
cord-002209-xs6qigg4	304	28	LRP1	LRP1	NNP
cord-002209-xs6qigg4	305	1	functionally	functionally	RB
cord-002209-xs6qigg4	305	2	associates	associate	NNS
cord-002209-xs6qigg4	305	3	with	with	IN
cord-002209-xs6qigg4	305	4	postsynaptic	postsynaptic	JJ
cord-002209-xs6qigg4	305	5	proteins	protein	NNS
cord-002209-xs6qigg4	305	6	and	and	CC
cord-002209-xs6qigg4	305	7	is	be	VBZ
cord-002209-xs6qigg4	305	8	required	require	VBN
cord-002209-xs6qigg4	305	9	for	for	IN
cord-002209-xs6qigg4	305	10	normal	normal	JJ
cord-002209-xs6qigg4	305	11	motor	motor	NN
cord-002209-xs6qigg4	305	12	function	function	NN
cord-002209-xs6qigg4	305	13	in	in	IN
cord-002209-xs6qigg4	305	14	mice	mouse	NNS
cord-002209-xs6qigg4	306	1	Ciliary	ciliary	JJ
cord-002209-xs6qigg4	306	2	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	306	3	factor	factor	NN
cord-002209-xs6qigg4	306	4	and	and	CC
cord-002209-xs6qigg4	306	5	leukemia	leukemia	NN
cord-002209-xs6qigg4	306	6	inhibitory	inhibitory	JJ
cord-002209-xs6qigg4	306	7	factor	factor	NN
cord-002209-xs6qigg4	306	8	promote	promote	VBP
cord-002209-xs6qigg4	306	9	the	the	DT
cord-002209-xs6qigg4	306	10	generation	generation	NN
cord-002209-xs6qigg4	306	11	,	,	,
cord-002209-xs6qigg4	306	12	maturation	maturation	NN
cord-002209-xs6qigg4	306	13	and	and	CC
cord-002209-xs6qigg4	306	14	survival	survival	NN
cord-002209-xs6qigg4	306	15	of	of	IN
cord-002209-xs6qigg4	306	16	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	306	17	in	in	IN
cord-002209-xs6qigg4	306	18	vitro	vitro	FW
cord-002209-xs6qigg4	306	19	Cytokine	cytokine	NN
cord-002209-xs6qigg4	306	20	,	,	,
cord-002209-xs6qigg4	306	21	chemokine	chemokine	NN
cord-002209-xs6qigg4	306	22	and	and	CC
cord-002209-xs6qigg4	306	23	growth	growth	NN
cord-002209-xs6qigg4	306	24	factor	factor	NN
cord-002209-xs6qigg4	306	25	gene	gene	NN
cord-002209-xs6qigg4	306	26	profiling	profiling	NN
cord-002209-xs6qigg4	306	27	of	of	IN
cord-002209-xs6qigg4	306	28	cultured	cultured	JJ
cord-002209-xs6qigg4	306	29	human	human	JJ
cord-002209-xs6qigg4	306	30	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	306	31	after	after	IN
cord-002209-xs6qigg4	306	32	exposure	exposure	NN
cord-002209-xs6qigg4	306	33	to	to	IN
cord-002209-xs6qigg4	306	34	proinflammatory	proinflammatory	JJ
cord-002209-xs6qigg4	306	35	stimuli	stimulus	NNS
cord-002209-xs6qigg4	307	1	Astroglial	Astroglial	NNP
cord-002209-xs6qigg4	307	2	connexin	connexin	NN
cord-002209-xs6qigg4	307	3	immunoreactivity	immunoreactivity	NN
cord-002209-xs6qigg4	307	4	is	be	VBZ
cord-002209-xs6qigg4	307	5	specifically	specifically	RB
cord-002209-xs6qigg4	307	6	altered	alter	VBN
cord-002209-xs6qigg4	307	7	at	at	IN
cord-002209-xs6qigg4	307	8	β	β	NN
cord-002209-xs6qigg4	307	9	-	-	HYPH
cord-002209-xs6qigg4	307	10	amyloid	amyloid	JJ
cord-002209-xs6qigg4	307	11	plaques	plaque	NNS
cord-002209-xs6qigg4	307	12	in	in	IN
cord-002209-xs6qigg4	308	1	β	β	LS
cord-002209-xs6qigg4	308	2	-	-	HYPH
cord-002209-xs6qigg4	308	3	amyloid	amyloid	NN
cord-002209-xs6qigg4	308	4	precursor	precursor	NN
cord-002209-xs6qigg4	308	5	protein	protein	NN
cord-002209-xs6qigg4	308	6	/	/	SYM
cord-002209-xs6qigg4	308	7	presenilin1	presenilin1	NN
cord-002209-xs6qigg4	308	8	mice	mice	NN
cord-002209-xs6qigg4	308	9	Connexins	Connexins	NNPS
cord-002209-xs6qigg4	308	10	are	be	VBP
cord-002209-xs6qigg4	308	11	critical	critical	JJ
cord-002209-xs6qigg4	308	12	for	for	IN
cord-002209-xs6qigg4	308	13	normal	normal	JJ
cord-002209-xs6qigg4	308	14	myelination	myelination	NN
cord-002209-xs6qigg4	308	15	in	in	IN
cord-002209-xs6qigg4	308	16	the	the	DT
cord-002209-xs6qigg4	308	17	CNS	CNS	NNP
cord-002209-xs6qigg4	308	18	Components	component	NNS
cord-002209-xs6qigg4	308	19	of	of	IN
cord-002209-xs6qigg4	308	20	glial	glial	JJ
cord-002209-xs6qigg4	308	21	responses	response	NNS
cord-002209-xs6qigg4	308	22	to	to	IN
cord-002209-xs6qigg4	308	23	exogenous	exogenous	JJ
cord-002209-xs6qigg4	308	24	and	and	CC
cord-002209-xs6qigg4	308	25	synaptic	synaptic	JJ
cord-002209-xs6qigg4	308	26	glutamate	glutamate	NN
cord-002209-xs6qigg4	308	27	in	in	IN
cord-002209-xs6qigg4	308	28	rat	rat	NN
cord-002209-xs6qigg4	308	29	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	308	30	microcultures	microcultures	FW
cord-002209-xs6qigg4	308	31	Fibroblast	Fibroblast	NNP
cord-002209-xs6qigg4	308	32	growth	growth	NN
cord-002209-xs6qigg4	308	33	factor	factor	NN
cord-002209-xs6qigg4	308	34	2	2	CD
cord-002209-xs6qigg4	309	1	(	(	-LRB-
cord-002209-xs6qigg4	309	2	FGF2	FGF2	NNP
cord-002209-xs6qigg4	309	3	)	)	-RRB-
cord-002209-xs6qigg4	309	4	and	and	CC
cord-002209-xs6qigg4	309	5	FGF	FGF	NNP
cord-002209-xs6qigg4	309	6	receptor	receptor	NN
cord-002209-xs6qigg4	309	7	expression	expression	NN
cord-002209-xs6qigg4	309	8	in	in	IN
cord-002209-xs6qigg4	309	9	an	an	DT
cord-002209-xs6qigg4	309	10	experimental	experimental	JJ
cord-002209-xs6qigg4	309	11	demyelinating	demyelinating	NN
cord-002209-xs6qigg4	309	12	disease	disease	NN
cord-002209-xs6qigg4	309	13	with	with	IN
cord-002209-xs6qigg4	310	1	extensive	extensive	JJ
cord-002209-xs6qigg4	310	2	remyelination	remyelination	NN
cord-002209-xs6qigg4	310	3	Astrocytes	Astrocytes	NNPS
cord-002209-xs6qigg4	310	4	stimulate	stimulate	VBP
cord-002209-xs6qigg4	310	5	interleukin-17	interleukin-17	NN
cord-002209-xs6qigg4	310	6	and	and	CC
cord-002209-xs6qigg4	310	7	interferon	interferon	NN
cord-002209-xs6qigg4	310	8	-	-	HYPH
cord-002209-xs6qigg4	310	9	gamma	gamma	NN
cord-002209-xs6qigg4	310	10	production	production	NN
cord-002209-xs6qigg4	311	1	in	in	IN
cord-002209-xs6qigg4	311	2	vitro	vitro	FW
cord-002209-xs6qigg4	312	1	How	how	WRB
cord-002209-xs6qigg4	312	2	factors	factor	NNS
cord-002209-xs6qigg4	312	3	secreted	secrete	VBN
cord-002209-xs6qigg4	312	4	from	from	IN
cord-002209-xs6qigg4	312	5	astrocytes	astrocytes	JJ
cord-002209-xs6qigg4	312	6	impact	impact	NN
cord-002209-xs6qigg4	312	7	myelin	myelin	NN
cord-002209-xs6qigg4	312	8	repair	repair	NN
cord-002209-xs6qigg4	312	9	D	d	NN
cord-002209-xs6qigg4	312	10	-	-	HYPH
cord-002209-xs6qigg4	312	11	serine	serine	NN
cord-002209-xs6qigg4	312	12	is	be	VBZ
cord-002209-xs6qigg4	312	13	an	an	DT
cord-002209-xs6qigg4	312	14	endogenous	endogenous	JJ
cord-002209-xs6qigg4	312	15	ligand	ligand	NN
cord-002209-xs6qigg4	312	16	for	for	IN
cord-002209-xs6qigg4	312	17	the	the	DT
cord-002209-xs6qigg4	312	18	glycine	glycine	NN
cord-002209-xs6qigg4	312	19	site	site	NN
cord-002209-xs6qigg4	312	20	of	of	IN
cord-002209-xs6qigg4	312	21	the	the	DT
cord-002209-xs6qigg4	312	22	N	n	CD
cord-002209-xs6qigg4	312	23	-	-	HYPH
cord-002209-xs6qigg4	312	24	methyl	methyl	NN
cord-002209-xs6qigg4	312	25	-	-	HYPH
cord-002209-xs6qigg4	312	26	D	d	NN
cord-002209-xs6qigg4	312	27	-	-	HYPH
cord-002209-xs6qigg4	312	28	aspartate	aspartate	NN
cord-002209-xs6qigg4	312	29	receptor	receptor	NN
cord-002209-xs6qigg4	312	30	Pathologische	Pathologische	NNP
cord-002209-xs6qigg4	312	31	anatomie	anatomie	NNP
cord-002209-xs6qigg4	313	1	und	und	NNP
cord-002209-xs6qigg4	314	1	pathogenese	pathogenese	NNP
cord-002209-xs6qigg4	314	2	Elevated	Elevated	NNP
cord-002209-xs6qigg4	314	3	connexin43	connexin43	JJ
cord-002209-xs6qigg4	314	4	immunoreactivity	immunoreactivity	NN
cord-002209-xs6qigg4	314	5	at	at	IN
cord-002209-xs6qigg4	314	6	sites	site	NNS
cord-002209-xs6qigg4	314	7	of	of	IN
cord-002209-xs6qigg4	314	8	amyloid	amyloid	NN
cord-002209-xs6qigg4	314	9	plaques	plaque	NNS
cord-002209-xs6qigg4	314	10	in	in	IN
cord-002209-xs6qigg4	314	11	Alzheimer	Alzheimer	NNP
cord-002209-xs6qigg4	314	12	's	's	POS
cord-002209-xs6qigg4	314	13	disease	disease	NN
cord-002209-xs6qigg4	314	14	Astrocyte	Astrocyte	NNP
cord-002209-xs6qigg4	314	15	phenotypes	phenotype	NNS
cord-002209-xs6qigg4	314	16	and	and	CC
cord-002209-xs6qigg4	314	17	their	-PRON-	PRP$
cord-002209-xs6qigg4	314	18	relationship	relationship	NN
cord-002209-xs6qigg4	314	19	to	to	IN
cord-002209-xs6qigg4	314	20	myelination	myelination	VB
cord-002209-xs6qigg4	314	21	Functional	functional	JJ
cord-002209-xs6qigg4	314	22	duality	duality	NN
cord-002209-xs6qigg4	314	23	of	of	IN
cord-002209-xs6qigg4	314	24	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	314	25	in	in	IN
cord-002209-xs6qigg4	314	26	myelination	myelination	NN
cord-002209-xs6qigg4	314	27	Specialized	Specialized	NNP
cord-002209-xs6qigg4	314	28	membrane	membrane	NN
cord-002209-xs6qigg4	314	29	domains	domain	NNS
cord-002209-xs6qigg4	314	30	for	for	IN
cord-002209-xs6qigg4	314	31	water	water	NN
cord-002209-xs6qigg4	314	32	transport	transport	NN
cord-002209-xs6qigg4	314	33	in	in	IN
cord-002209-xs6qigg4	314	34	glial	glial	JJ
cord-002209-xs6qigg4	314	35	cells	cell	NNS
cord-002209-xs6qigg4	314	36	:	:	:
cord-002209-xs6qigg4	314	37	highresolution	highresolution	NNP
cord-002209-xs6qigg4	314	38	immunogold	immunogold	NNP
cord-002209-xs6qigg4	314	39	cytochemistry	cytochemistry	NNP
cord-002209-xs6qigg4	314	40	of	of	IN
cord-002209-xs6qigg4	314	41	aquaporin-4	aquaporin-4	NNP
cord-002209-xs6qigg4	314	42	in	in	IN
cord-002209-xs6qigg4	314	43	rat	rat	NN
cord-002209-xs6qigg4	314	44	brain	brain	NN
cord-002209-xs6qigg4	315	1	Purified	purify	VBN
cord-002209-xs6qigg4	315	2	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	315	3	promote	promote	VBP
cord-002209-xs6qigg4	315	4	the	the	DT
cord-002209-xs6qigg4	315	5	in	in	FW
cord-002209-xs6qigg4	315	6	vitro	vitro	FW
cord-002209-xs6qigg4	315	7	division	division	NN
cord-002209-xs6qigg4	315	8	of	of	IN
cord-002209-xs6qigg4	315	9	a	a	DT
cord-002209-xs6qigg4	315	10	bipotential	bipotential	JJ
cord-002209-xs6qigg4	315	11	glial	glial	JJ
cord-002209-xs6qigg4	315	12	progenitor	progenitor	NN
cord-002209-xs6qigg4	315	13	cell	cell	NN
cord-002209-xs6qigg4	315	14	Platelet	platelet	NN
cord-002209-xs6qigg4	315	15	-	-	HYPH
cord-002209-xs6qigg4	315	16	derived	derive	VBN
cord-002209-xs6qigg4	315	17	growth	growth	NN
cord-002209-xs6qigg4	315	18	factor	factor	NN
cord-002209-xs6qigg4	315	19	promotes	promote	VBZ
cord-002209-xs6qigg4	315	20	division	division	NN
cord-002209-xs6qigg4	315	21	and	and	CC
cord-002209-xs6qigg4	315	22	motility	motility	NN
cord-002209-xs6qigg4	315	23	and	and	CC
cord-002209-xs6qigg4	315	24	inhibits	inhibit	VBZ
cord-002209-xs6qigg4	315	25	premature	premature	JJ
cord-002209-xs6qigg4	315	26	differentiation	differentiation	NN
cord-002209-xs6qigg4	315	27	of	of	IN
cord-002209-xs6qigg4	315	28	the	the	DT
cord-002209-xs6qigg4	315	29	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	315	30	/	/	SYM
cord-002209-xs6qigg4	315	31	type-2	type-2	NNP
cord-002209-xs6qigg4	315	32	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	315	33	progenitor	progenitor	NN
cord-002209-xs6qigg4	315	34	cell	cell	NN
cord-002209-xs6qigg4	316	1	The	the	DT
cord-002209-xs6qigg4	316	2	complex	complex	JJ
cord-002209-xs6qigg4	316	3	relationship	relationship	NN
cord-002209-xs6qigg4	316	4	between	between	IN
cord-002209-xs6qigg4	316	5	cell	cell	NN
cord-002209-xs6qigg4	316	6	division	division	NN
cord-002209-xs6qigg4	316	7	and	and	CC
cord-002209-xs6qigg4	316	8	the	the	DT
cord-002209-xs6qigg4	316	9	control	control	NN
cord-002209-xs6qigg4	316	10	of	of	IN
cord-002209-xs6qigg4	316	11	differentiation	differentiation	NN
cord-002209-xs6qigg4	316	12	in	in	IN
cord-002209-xs6qigg4	316	13	oligodendrocyte	oligodendrocyte	VBN
cord-002209-xs6qigg4	316	14	-	-	HYPH
cord-002209-xs6qigg4	316	15	type-2	type-2	NN
cord-002209-xs6qigg4	316	16	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	316	17	progenitor	progenitor	NN
cord-002209-xs6qigg4	316	18	cells	cell	NNS
cord-002209-xs6qigg4	316	19	isolated	isolate	VBN
cord-002209-xs6qigg4	316	20	from	from	IN
cord-002209-xs6qigg4	316	21	perinatal	perinatal	JJ
cord-002209-xs6qigg4	316	22	and	and	CC
cord-002209-xs6qigg4	316	23	adult	adult	NN
cord-002209-xs6qigg4	316	24	rat	rat	NN
cord-002209-xs6qigg4	316	25	optic	optic	NN
cord-002209-xs6qigg4	316	26	nerves	nerve	NNS
cord-002209-xs6qigg4	316	27	Connexin	Connexin	NNP
cord-002209-xs6qigg4	316	28	47	47	CD
cord-002209-xs6qigg4	317	1	(	(	-LRB-
cord-002209-xs6qigg4	317	2	Cx47)-deficient	Cx47)-deficient	NNP
cord-002209-xs6qigg4	317	3	mice	mouse	NNS
cord-002209-xs6qigg4	317	4	with	with	IN
cord-002209-xs6qigg4	317	5	enhanced	enhanced	JJ
cord-002209-xs6qigg4	317	6	green	green	JJ
cord-002209-xs6qigg4	317	7	fluorescent	fluorescent	NN
cord-002209-xs6qigg4	317	8	protein	protein	NN
cord-002209-xs6qigg4	317	9	reporter	reporter	NN
cord-002209-xs6qigg4	317	10	gene	gene	NN
cord-002209-xs6qigg4	317	11	reveal	reveal	VBP
cord-002209-xs6qigg4	317	12	predominant	predominant	JJ
cord-002209-xs6qigg4	317	13	oligodendrocytic	oligodendrocytic	JJ
cord-002209-xs6qigg4	317	14	expression	expression	NN
cord-002209-xs6qigg4	317	15	of	of	IN
cord-002209-xs6qigg4	317	16	Cx47	Cx47	NNP
cord-002209-xs6qigg4	318	1	and	and	CC
cord-002209-xs6qigg4	318	2	display	display	VB
cord-002209-xs6qigg4	318	3	vacuolized	vacuolize	VBN
cord-002209-xs6qigg4	318	4	myelin	myelin	NN
cord-002209-xs6qigg4	318	5	in	in	IN
cord-002209-xs6qigg4	318	6	the	the	DT
cord-002209-xs6qigg4	318	7	CNS	CNS	NNP
cord-002209-xs6qigg4	318	8	Conditional	conditional	JJ
cord-002209-xs6qigg4	318	9	ablation	ablation	NN
cord-002209-xs6qigg4	318	10	of	of	IN
cord-002209-xs6qigg4	318	11	Stat3	Stat3	NNP
cord-002209-xs6qigg4	318	12	or	or	CC
cord-002209-xs6qigg4	318	13	Socs3	Socs3	NNP
cord-002209-xs6qigg4	318	14	discloses	disclose	VBZ
cord-002209-xs6qigg4	318	15	a	a	DT
cord-002209-xs6qigg4	318	16	dual	dual	JJ
cord-002209-xs6qigg4	318	17	role	role	NN
cord-002209-xs6qigg4	318	18	for	for	IN
cord-002209-xs6qigg4	318	19	reactive	reactive	JJ
cord-002209-xs6qigg4	318	20	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	318	21	after	after	IN
cord-002209-xs6qigg4	318	22	spinal	spinal	JJ
cord-002209-xs6qigg4	318	23	cord	cord	NN
cord-002209-xs6qigg4	318	24	injury	injury	NN
cord-002209-xs6qigg4	318	25	CXC	CXC	NNP
cord-002209-xs6qigg4	318	26	chemokine	chemokine	NN
cord-002209-xs6qigg4	318	27	receptors	receptor	NNS
cord-002209-xs6qigg4	318	28	on	on	IN
cord-002209-xs6qigg4	318	29	human	human	JJ
cord-002209-xs6qigg4	318	30	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	318	31	:	:	:
cord-002209-xs6qigg4	318	32	implications	implication	NNS
cord-002209-xs6qigg4	318	33	for	for	IN
cord-002209-xs6qigg4	318	34	multiple	multiple	JJ
cord-002209-xs6qigg4	318	35	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	318	36	Cholesterol	cholesterol	NN
cord-002209-xs6qigg4	318	37	:	:	:
cord-002209-xs6qigg4	319	1	Its	-PRON-	PRP$
cord-002209-xs6qigg4	319	2	regulation	regulation	NN
cord-002209-xs6qigg4	319	3	and	and	CC
cord-002209-xs6qigg4	319	4	role	role	NN
cord-002209-xs6qigg4	319	5	in	in	IN
cord-002209-xs6qigg4	319	6	central	central	JJ
cord-002209-xs6qigg4	319	7	nervous	nervous	JJ
cord-002209-xs6qigg4	319	8	system	system	NN
cord-002209-xs6qigg4	319	9	disorders	disorder	NNS
cord-002209-xs6qigg4	319	10	Astroglial	astroglial	JJ
cord-002209-xs6qigg4	319	11	networks	network	NNS
cord-002209-xs6qigg4	319	12	scale	scale	VBP
cord-002209-xs6qigg4	319	13	synaptic	synaptic	JJ
cord-002209-xs6qigg4	319	14	activity	activity	NN
cord-002209-xs6qigg4	319	15	and	and	CC
cord-002209-xs6qigg4	319	16	plasticity	plasticity	NN
cord-002209-xs6qigg4	320	1	Glutamatemediated	Glutamatemediated	NNP
cord-002209-xs6qigg4	321	1	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	321	2	-	-	HYPH
cord-002209-xs6qigg4	321	3	neuron	neuron	NN
cord-002209-xs6qigg4	321	4	signalling	signal	VBG
cord-002209-xs6qigg4	321	5	Cloning	cloning	NN
cord-002209-xs6qigg4	321	6	,	,	,
cord-002209-xs6qigg4	321	7	localization	localization	NN
cord-002209-xs6qigg4	321	8	and	and	CC
cord-002209-xs6qigg4	321	9	induction	induction	NN
cord-002209-xs6qigg4	321	10	of	of	IN
cord-002209-xs6qigg4	321	11	mouse	mouse	NN
cord-002209-xs6qigg4	321	12	brain	brain	NN
cord-002209-xs6qigg4	321	13	glycogen	glycogen	NN
cord-002209-xs6qigg4	321	14	synthase	synthase	NN
cord-002209-xs6qigg4	321	15	Immunocytochemical	Immunocytochemical	NNP
cord-002209-xs6qigg4	321	16	localization	localization	NN
cord-002209-xs6qigg4	321	17	of	of	IN
cord-002209-xs6qigg4	321	18	glycogen	glycogen	NN
cord-002209-xs6qigg4	321	19	phosphorylase	phosphorylase	NNP
cord-002209-xs6qigg4	321	20	isozymes	isozyme	NNS
cord-002209-xs6qigg4	321	21	in	in	IN
cord-002209-xs6qigg4	321	22	rat	rat	NN
cord-002209-xs6qigg4	321	23	nervous	nervous	JJ
cord-002209-xs6qigg4	321	24	tissues	tissue	NNS
cord-002209-xs6qigg4	321	25	by	by	IN
cord-002209-xs6qigg4	321	26	using	use	VBG
cord-002209-xs6qigg4	321	27	isozyme	isozyme	NNS
cord-002209-xs6qigg4	321	28	-	-	HYPH
cord-002209-xs6qigg4	321	29	specific	specific	JJ
cord-002209-xs6qigg4	321	30	antibodies	antibody	NNS
cord-002209-xs6qigg4	321	31	Cholesterol	cholesterol	VBP
cord-002209-xs6qigg4	321	32	metabolism	metabolism	NN
cord-002209-xs6qigg4	321	33	in	in	IN
cord-002209-xs6qigg4	321	34	neurons	neuron	NNS
cord-002209-xs6qigg4	321	35	and	and	CC
cord-002209-xs6qigg4	321	36	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	321	37	Astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	321	38	neurotransmitter	neurotransmitter	NN
cord-002209-xs6qigg4	321	39	receptors	receptor	NNS
cord-002209-xs6qigg4	321	40	in	in	IN
cord-002209-xs6qigg4	321	41	situ	situ	NN
cord-002209-xs6qigg4	321	42	and	and	CC
cord-002209-xs6qigg4	321	43	in	in	IN
cord-002209-xs6qigg4	322	1	vivo	vivo	NNP
cord-002209-xs6qigg4	322	2	PDGF	PDGF	NNP
cord-002209-xs6qigg4	322	3	A	a	DT
cord-002209-xs6qigg4	322	4	chain	chain	NN
cord-002209-xs6qigg4	322	5	homodimers	homodimer	NNS
cord-002209-xs6qigg4	322	6	drive	drive	VBP
cord-002209-xs6qigg4	322	7	proliferation	proliferation	NN
cord-002209-xs6qigg4	322	8	of	of	IN
cord-002209-xs6qigg4	322	9	bipotential	bipotential	NN
cord-002209-xs6qigg4	322	10	(	(	-LRB-
cord-002209-xs6qigg4	322	11	O-2A	O-2A	NNP
cord-002209-xs6qigg4	322	12	)	)	-RRB-
cord-002209-xs6qigg4	322	13	glial	glial	JJ
cord-002209-xs6qigg4	322	14	progenitor	progenitor	NN
cord-002209-xs6qigg4	322	15	cells	cell	NNS
cord-002209-xs6qigg4	322	16	in	in	IN
cord-002209-xs6qigg4	322	17	the	the	DT
cord-002209-xs6qigg4	322	18	developing	develop	VBG
cord-002209-xs6qigg4	322	19	rat	rat	NN
cord-002209-xs6qigg4	322	20	optic	optic	JJ
cord-002209-xs6qigg4	322	21	nerve	nerve	NN
cord-002209-xs6qigg4	322	22	Cultured	cultured	JJ
cord-002209-xs6qigg4	322	23	human	human	JJ
cord-002209-xs6qigg4	322	24	fetal	fetal	NN
cord-002209-xs6qigg4	322	25	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	322	26	can	can	MD
cord-002209-xs6qigg4	322	27	be	be	VB
cord-002209-xs6qigg4	322	28	induced	induce	VBN
cord-002209-xs6qigg4	322	29	by	by	IN
cord-002209-xs6qigg4	322	30	interferon	interferon	NN
cord-002209-xs6qigg4	322	31	-	-	HYPH
cord-002209-xs6qigg4	322	32	gamma	gamma	NN
cord-002209-xs6qigg4	322	33	to	to	TO
cord-002209-xs6qigg4	322	34	express	express	VB
cord-002209-xs6qigg4	322	35	HLA	HLA	NNP
cord-002209-xs6qigg4	322	36	-	-	HYPH
cord-002209-xs6qigg4	322	37	DR	DR	NNP
cord-002209-xs6qigg4	322	38	A	a	DT
cord-002209-xs6qigg4	322	39	glial	glial	JJ
cord-002209-xs6qigg4	322	40	progenitor	progenitor	NN
cord-002209-xs6qigg4	322	41	cell	cell	NN
cord-002209-xs6qigg4	322	42	that	that	WDT
cord-002209-xs6qigg4	322	43	develops	develop	VBZ
cord-002209-xs6qigg4	322	44	in	in	IN
cord-002209-xs6qigg4	322	45	vitro	vitro	FW
cord-002209-xs6qigg4	322	46	into	into	IN
cord-002209-xs6qigg4	322	47	an	an	DT
cord-002209-xs6qigg4	322	48	astrocyte	astrocyte	NN
cord-002209-xs6qigg4	322	49	or	or	CC
cord-002209-xs6qigg4	322	50	an	an	DT
cord-002209-xs6qigg4	322	51	oligodendrocyte	oligodendrocyte	JJ
cord-002209-xs6qigg4	322	52	depending	depend	VBG
cord-002209-xs6qigg4	322	53	on	on	IN
cord-002209-xs6qigg4	322	54	culture	culture	NN
cord-002209-xs6qigg4	322	55	medium	medium	NN
cord-002209-xs6qigg4	322	56	Platelet	platelet	NN
cord-002209-xs6qigg4	322	57	-	-	HYPH
cord-002209-xs6qigg4	322	58	derived	derive	VBN
cord-002209-xs6qigg4	322	59	growth	growth	NN
cord-002209-xs6qigg4	322	60	factor	factor	NN
cord-002209-xs6qigg4	322	61	from	from	IN
cord-002209-xs6qigg4	322	62	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	322	63	drives	drive	VBZ
cord-002209-xs6qigg4	322	64	the	the	DT
cord-002209-xs6qigg4	322	65	clock	clock	NN
cord-002209-xs6qigg4	322	66	that	that	WDT
cord-002209-xs6qigg4	322	67	times	times	NNP
cord-002209-xs6qigg4	322	68	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	322	69	development	development	NN
cord-002209-xs6qigg4	322	70	in	in	IN
cord-002209-xs6qigg4	322	71	culture	culture	NN
cord-002209-xs6qigg4	322	72	Astrocyte	Astrocyte	NNP
cord-002209-xs6qigg4	322	73	expression	expression	NN
cord-002209-xs6qigg4	322	74	of	of	IN
cord-002209-xs6qigg4	322	75	mRNA	mrna	NN
cord-002209-xs6qigg4	322	76	encoding	encode	VBG
cord-002209-xs6qigg4	322	77	cytokines	cytokine	NNS
cord-002209-xs6qigg4	322	78	IP-10	IP-10	NNP
cord-002209-xs6qigg4	322	79	and	and	CC
cord-002209-xs6qigg4	322	80	JE	JE	NNP
cord-002209-xs6qigg4	322	81	/	/	SYM
cord-002209-xs6qigg4	322	82	MCP-1	MCP-1	NNP
cord-002209-xs6qigg4	322	83	in	in	IN
cord-002209-xs6qigg4	322	84	experimental	experimental	JJ
cord-002209-xs6qigg4	322	85	autoimmune	autoimmune	JJ
cord-002209-xs6qigg4	322	86	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	322	87	Direct	direct	JJ
cord-002209-xs6qigg4	322	88	immunogold	immunogold	JJ
cord-002209-xs6qigg4	322	89	labeling	labeling	NN
cord-002209-xs6qigg4	322	90	of	of	IN
cord-002209-xs6qigg4	322	91	aquaporin-4	aquaporin-4	NNP
cord-002209-xs6qigg4	322	92	in	in	IN
cord-002209-xs6qigg4	322	93	square	square	JJ
cord-002209-xs6qigg4	322	94	arrays	array	NNS
cord-002209-xs6qigg4	322	95	of	of	IN
cord-002209-xs6qigg4	322	96	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	322	97	and	and	CC
cord-002209-xs6qigg4	322	98	ependymocyte	ependymocyte	NNP
cord-002209-xs6qigg4	322	99	plasma	plasma	NN
cord-002209-xs6qigg4	322	100	membranes	membrane	NNS
cord-002209-xs6qigg4	322	101	in	in	IN
cord-002209-xs6qigg4	322	102	rat	rat	NN
cord-002209-xs6qigg4	322	103	brain	brain	NN
cord-002209-xs6qigg4	322	104	and	and	CC
cord-002209-xs6qigg4	322	105	spinal	spinal	JJ
cord-002209-xs6qigg4	322	106	cord	cord	NN
cord-002209-xs6qigg4	323	1	In	in	IN
cord-002209-xs6qigg4	323	2	vivo	vivo	NN
cord-002209-xs6qigg4	323	3	proliferation	proliferation	NN
cord-002209-xs6qigg4	323	4	of	of	IN
cord-002209-xs6qigg4	323	5	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	323	6	progenitors	progenitor	NNS
cord-002209-xs6qigg4	323	7	expressing	express	VBG
cord-002209-xs6qigg4	323	8	PDGFalphaR	PDGFalphaR	NNS
cord-002209-xs6qigg4	323	9	during	during	IN
cord-002209-xs6qigg4	323	10	early	early	JJ
cord-002209-xs6qigg4	323	11	remyelination	remyelination	NN
cord-002209-xs6qigg4	324	1	In	in	IN
cord-002209-xs6qigg4	324	2	situ	situ	JJ
cord-002209-xs6qigg4	324	3	expression	expression	NN
cord-002209-xs6qigg4	324	4	of	of	IN
cord-002209-xs6qigg4	324	5	fibroblast	fibroblast	NN
cord-002209-xs6qigg4	324	6	growth	growth	NN
cord-002209-xs6qigg4	324	7	factor	factor	NN
cord-002209-xs6qigg4	324	8	receptors	receptor	NNS
cord-002209-xs6qigg4	324	9	by	by	IN
cord-002209-xs6qigg4	324	10	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	324	11	progenitors	progenitor	NNS
cord-002209-xs6qigg4	324	12	and	and	CC
cord-002209-xs6qigg4	324	13	oligodendrocytes	oligodendrocyte	NNS
cord-002209-xs6qigg4	324	14	in	in	IN
cord-002209-xs6qigg4	324	15	adult	adult	NN
cord-002209-xs6qigg4	324	16	mouse	mouse	NN
cord-002209-xs6qigg4	324	17	central	central	JJ
cord-002209-xs6qigg4	324	18	nervous	nervous	JJ
cord-002209-xs6qigg4	324	19	system	system	NN
cord-002209-xs6qigg4	324	20	Neuroscience	Neuroscience	NNP
cord-002209-xs6qigg4	324	21	:	:	:
cord-002209-xs6qigg4	324	22	the	the	DT
cord-002209-xs6qigg4	324	23	wrap	wrap	NN
cord-002209-xs6qigg4	324	24	that	that	WDT
cord-002209-xs6qigg4	324	25	feeds	feed	VBZ
cord-002209-xs6qigg4	324	26	neurons	neuron	NNS
cord-002209-xs6qigg4	324	27	Regulation	Regulation	NNP
cord-002209-xs6qigg4	324	28	of	of	IN
cord-002209-xs6qigg4	324	29	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	324	30	development	development	NN
cord-002209-xs6qigg4	324	31	and	and	CC
cord-002209-xs6qigg4	324	32	myelination	myelination	NN
cord-002209-xs6qigg4	324	33	by	by	IN
cord-002209-xs6qigg4	324	34	glucose	glucose	NN
cord-002209-xs6qigg4	324	35	and	and	CC
cord-002209-xs6qigg4	324	36	lactate	lactate	VB
cord-002209-xs6qigg4	324	37	Astroglial	astroglial	JJ
cord-002209-xs6qigg4	324	38	metabolic	metabolic	JJ
cord-002209-xs6qigg4	324	39	networks	network	NNS
cord-002209-xs6qigg4	324	40	sustain	sustain	VBP
cord-002209-xs6qigg4	324	41	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	324	42	synaptic	synaptic	JJ
cord-002209-xs6qigg4	324	43	transmission	transmission	NN
cord-002209-xs6qigg4	324	44	Changes	change	NNS
cord-002209-xs6qigg4	324	45	in	in	IN
cord-002209-xs6qigg4	324	46	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	324	47	factor	factor	NN
cord-002209-xs6qigg4	324	48	expression	expression	NN
cord-002209-xs6qigg4	324	49	and	and	CC
cord-002209-xs6qigg4	324	50	receptor	receptor	NN
cord-002209-xs6qigg4	324	51	activation	activation	NN
cord-002209-xs6qigg4	324	52	following	follow	VBG
cord-002209-xs6qigg4	324	53	exposure	exposure	NN
cord-002209-xs6qigg4	324	54	of	of	IN
cord-002209-xs6qigg4	324	55	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	324	56	neuron/	neuron/	NNP
cord-002209-xs6qigg4	324	57	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	324	58	cocultures	cocultures	NNP
cord-002209-xs6qigg4	324	59	to	to	TO
cord-002209-xs6qigg4	324	60	kainic	kainic	NNP
cord-002209-xs6qigg4	324	61	acid	acid	NN
cord-002209-xs6qigg4	324	62	Ciliary	Ciliary	NNP
cord-002209-xs6qigg4	324	63	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	324	64	factor	factor	NN
cord-002209-xs6qigg4	324	65	role	role	NN
cord-002209-xs6qigg4	324	66	in	in	IN
cord-002209-xs6qigg4	324	67	myelin	myelin	NN
cord-002209-xs6qigg4	324	68	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	324	69	glycoprotein	glycoprotein	NNP
cord-002209-xs6qigg4	324	70	expression	expression	NN
cord-002209-xs6qigg4	324	71	in	in	IN
cord-002209-xs6qigg4	325	1	cuprizone	cuprizone	NN
cord-002209-xs6qigg4	325	2	-	-	HYPH
cord-002209-xs6qigg4	325	3	induced	induce	VBN
cord-002209-xs6qigg4	325	4	multiple	multiple	JJ
cord-002209-xs6qigg4	325	5	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	325	6	mice	mouse	NNS
cord-002209-xs6qigg4	325	7	Oligodendrocytes	Oligodendrocytes	NNPS
cord-002209-xs6qigg4	325	8	use	use	VBP
cord-002209-xs6qigg4	325	9	lactate	lactate	NN
cord-002209-xs6qigg4	325	10	as	as	IN
cord-002209-xs6qigg4	325	11	a	a	DT
cord-002209-xs6qigg4	325	12	source	source	NN
cord-002209-xs6qigg4	325	13	of	of	IN
cord-002209-xs6qigg4	325	14	energy	energy	NN
cord-002209-xs6qigg4	325	15	and	and	CC
cord-002209-xs6qigg4	325	16	as	as	IN
cord-002209-xs6qigg4	325	17	a	a	DT
cord-002209-xs6qigg4	325	18	precursor	precursor	NN
cord-002209-xs6qigg4	325	19	of	of	IN
cord-002209-xs6qigg4	325	20	lipids	lipid	NNS
cord-002209-xs6qigg4	326	1	The	the	DT
cord-002209-xs6qigg4	326	2	"	"	``
cord-002209-xs6qigg4	326	3	quad	quad	JJ
cord-002209-xs6qigg4	326	4	-	-	HYPH
cord-002209-xs6qigg4	326	5	partite	partite	FW
cord-002209-xs6qigg4	326	6	"	"	''
cord-002209-xs6qigg4	326	7	synapse	synapse	NN
cord-002209-xs6qigg4	326	8	:	:	:
cord-002209-xs6qigg4	326	9	microgliasynapse	microgliasynapse	NNP
cord-002209-xs6qigg4	326	10	interactions	interaction	NNS
cord-002209-xs6qigg4	326	11	in	in	IN
cord-002209-xs6qigg4	326	12	the	the	DT
cord-002209-xs6qigg4	326	13	developing	develop	VBG
cord-002209-xs6qigg4	326	14	and	and	CC
cord-002209-xs6qigg4	326	15	mature	mature	VB
cord-002209-xs6qigg4	326	16	CNS	CNS	NNP
cord-002209-xs6qigg4	326	17	Iron	Iron	NNP
cord-002209-xs6qigg4	326	18	efflux	efflux	NN
cord-002209-xs6qigg4	326	19	from	from	IN
cord-002209-xs6qigg4	326	20	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	326	21	plays	play	VBZ
cord-002209-xs6qigg4	326	22	a	a	DT
cord-002209-xs6qigg4	326	23	role	role	NN
cord-002209-xs6qigg4	326	24	in	in	IN
cord-002209-xs6qigg4	326	25	remyelination	remyelination	NN
cord-002209-xs6qigg4	326	26	Neurotrophic	Neurotrophic	NNP
cord-002209-xs6qigg4	326	27	factor	factor	NN
cord-002209-xs6qigg4	326	28	gene	gene	NN
cord-002209-xs6qigg4	326	29	expression	expression	NN
cord-002209-xs6qigg4	326	30	in	in	IN
cord-002209-xs6qigg4	326	31	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	326	32	during	during	IN
cord-002209-xs6qigg4	326	33	development	development	NN
cord-002209-xs6qigg4	326	34	and	and	CC
cord-002209-xs6qigg4	326	35	following	follow	VBG
cord-002209-xs6qigg4	326	36	injury	injury	NN
cord-002209-xs6qigg4	326	37	Tumor	tumor	NN
cord-002209-xs6qigg4	326	38	necrosis	necrosis	NN
cord-002209-xs6qigg4	326	39	factor	factor	NN
cord-002209-xs6qigg4	326	40	mediates	mediate	VBZ
cord-002209-xs6qigg4	326	41	myelin	myelin	JJ
cord-002209-xs6qigg4	326	42	damage	damage	NN
cord-002209-xs6qigg4	326	43	in	in	IN
cord-002209-xs6qigg4	326	44	organotypic	organotypic	JJ
cord-002209-xs6qigg4	326	45	cultures	culture	NNS
cord-002209-xs6qigg4	326	46	of	of	IN
cord-002209-xs6qigg4	326	47	nervous	nervous	JJ
cord-002209-xs6qigg4	326	48	tissue	tissue	NN
cord-002209-xs6qigg4	326	49	Identification	identification	NN
cord-002209-xs6qigg4	326	50	of	of	IN
cord-002209-xs6qigg4	326	51	lymphotoxin	lymphotoxin	NN
cord-002209-xs6qigg4	326	52	and	and	CC
cord-002209-xs6qigg4	326	53	tumor	tumor	NN
cord-002209-xs6qigg4	326	54	necrosis	necrosis	NN
cord-002209-xs6qigg4	326	55	factor	factor	NN
cord-002209-xs6qigg4	326	56	in	in	IN
cord-002209-xs6qigg4	326	57	multiple	multiple	JJ
cord-002209-xs6qigg4	326	58	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	326	59	lesions	lesion	NNS
cord-002209-xs6qigg4	326	60	Basic	basic	JJ
cord-002209-xs6qigg4	326	61	Neurochemistry	Neurochemistry	NNP
cord-002209-xs6qigg4	326	62	:	:	:
cord-002209-xs6qigg4	326	63	Molecular	Molecular	NNP
cord-002209-xs6qigg4	326	64	,	,	,
cord-002209-xs6qigg4	326	65	Cellular	Cellular	NNP
cord-002209-xs6qigg4	326	66	and	and	CC
cord-002209-xs6qigg4	326	67	Medical	Medical	NNP
cord-002209-xs6qigg4	326	68	Aspects	Aspects	NNPS
cord-002209-xs6qigg4	326	69	Cytokine	cytokine	NN
cord-002209-xs6qigg4	326	70	-	-	HYPH
cord-002209-xs6qigg4	326	71	regulated	regulate	VBN
cord-002209-xs6qigg4	326	72	expression	expression	NN
cord-002209-xs6qigg4	326	73	of	of	IN
cord-002209-xs6qigg4	326	74	platelet	platelet	NN
cord-002209-xs6qigg4	326	75	-	-	HYPH
cord-002209-xs6qigg4	326	76	derived	derive	VBN
cord-002209-xs6qigg4	326	77	growth	growth	NN
cord-002209-xs6qigg4	326	78	factor	factor	NN
cord-002209-xs6qigg4	326	79	gene	gene	NN
cord-002209-xs6qigg4	326	80	and	and	CC
cord-002209-xs6qigg4	326	81	protein	protein	NN
cord-002209-xs6qigg4	326	82	in	in	IN
cord-002209-xs6qigg4	326	83	cultured	cultured	JJ
cord-002209-xs6qigg4	326	84	human	human	JJ
cord-002209-xs6qigg4	326	85	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	326	86	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	326	87	:	:	:
cord-002209-xs6qigg4	326	88	biology	biology	NN
cord-002209-xs6qigg4	326	89	and	and	CC
cord-002209-xs6qigg4	326	90	pathology	pathology	NN
cord-002209-xs6qigg4	326	91	Sevenfold	Sevenfold	NNP
cord-002209-xs6qigg4	326	92	-	-	HYPH
cord-002209-xs6qigg4	326	93	reduced	reduce	VBN
cord-002209-xs6qigg4	326	94	osmotic	osmotic	JJ
cord-002209-xs6qigg4	326	95	water	water	NN
cord-002209-xs6qigg4	326	96	permeability	permeability	NN
cord-002209-xs6qigg4	326	97	in	in	IN
cord-002209-xs6qigg4	326	98	primary	primary	JJ
cord-002209-xs6qigg4	326	99	astrocyte	astrocyte	NNP
cord-002209-xs6qigg4	326	100	cultures	culture	NNS
cord-002209-xs6qigg4	326	101	from	from	IN
cord-002209-xs6qigg4	326	102	AQP-4-deficient	AQP-4-deficient	NNP
cord-002209-xs6qigg4	326	103	mice	mouse	NNS
cord-002209-xs6qigg4	326	104	,	,	,
cord-002209-xs6qigg4	326	105	measured	measure	VBN
cord-002209-xs6qigg4	326	106	by	by	IN
cord-002209-xs6qigg4	326	107	a	a	DT
cord-002209-xs6qigg4	326	108	fluorescence	fluorescence	NN
cord-002209-xs6qigg4	326	109	quenching	quenching	NN
cord-002209-xs6qigg4	326	110	method	method	NN
cord-002209-xs6qigg4	326	111	Ciliary	Ciliary	NNP
cord-002209-xs6qigg4	326	112	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	326	113	factor	factor	NN
cord-002209-xs6qigg4	326	114	(	(	-LRB-
cord-002209-xs6qigg4	326	115	CNTF	CNTF	NNP
cord-002209-xs6qigg4	326	116	)	)	-RRB-
cord-002209-xs6qigg4	326	117	enhances	enhance	VBZ
cord-002209-xs6qigg4	326	118	myelin	myelin	NN
cord-002209-xs6qigg4	326	119	formation	formation	NN
cord-002209-xs6qigg4	326	120	:	:	:
cord-002209-xs6qigg4	327	1	a	a	DT
cord-002209-xs6qigg4	327	2	novel	novel	JJ
cord-002209-xs6qigg4	327	3	role	role	NN
cord-002209-xs6qigg4	327	4	for	for	IN
cord-002209-xs6qigg4	327	5	CNTF	CNTF	NNP
cord-002209-xs6qigg4	327	6	and	and	CC
cord-002209-xs6qigg4	327	7	CNTF	CNTF	NNP
cord-002209-xs6qigg4	327	8	-	-	HYPH
cord-002209-xs6qigg4	327	9	related	relate	VBN
cord-002209-xs6qigg4	327	10	molecules	molecule	NNS
cord-002209-xs6qigg4	327	11	Properties	property	NNS
cord-002209-xs6qigg4	327	12	of	of	IN
cord-002209-xs6qigg4	327	13	GABA	GABA	NNP
cord-002209-xs6qigg4	327	14	and	and	CC
cord-002209-xs6qigg4	327	15	glutamate	glutamate	NN
cord-002209-xs6qigg4	327	16	responses	response	NNS
cord-002209-xs6qigg4	327	17	in	in	IN
cord-002209-xs6qigg4	327	18	identified	identify	VBN
cord-002209-xs6qigg4	327	19	glial	glial	JJ
cord-002209-xs6qigg4	327	20	cells	cell	NNS
cord-002209-xs6qigg4	327	21	of	of	IN
cord-002209-xs6qigg4	327	22	the	the	DT
cord-002209-xs6qigg4	327	23	mouse	mouse	NN
cord-002209-xs6qigg4	327	24	hippocampal	hippocampal	NN
cord-002209-xs6qigg4	327	25	slice	slice	NN
cord-002209-xs6qigg4	327	26	Regional	regional	JJ
cord-002209-xs6qigg4	327	27	distribution	distribution	NN
cord-002209-xs6qigg4	327	28	,	,	,
cord-002209-xs6qigg4	327	29	developmental	developmental	JJ
cord-002209-xs6qigg4	327	30	changes	change	NNS
cord-002209-xs6qigg4	327	31	,	,	,
cord-002209-xs6qigg4	327	32	and	and	CC
cord-002209-xs6qigg4	327	33	cellular	cellular	JJ
cord-002209-xs6qigg4	327	34	localization	localization	NN
cord-002209-xs6qigg4	327	35	of	of	IN
cord-002209-xs6qigg4	327	36	CNTF	CNTF	NNP
cord-002209-xs6qigg4	327	37	-	-	HYPH
cord-002209-xs6qigg4	327	38	mRNA	mrna	NN
cord-002209-xs6qigg4	327	39	and	and	CC
cord-002209-xs6qigg4	327	40	protein	protein	NN
cord-002209-xs6qigg4	327	41	in	in	IN
cord-002209-xs6qigg4	327	42	the	the	DT
cord-002209-xs6qigg4	327	43	rat	rat	NN
cord-002209-xs6qigg4	327	44	brain	brain	NN
cord-002209-xs6qigg4	327	45	Transfer	transfer	NN
cord-002209-xs6qigg4	327	46	of	of	IN
cord-002209-xs6qigg4	327	47	glycogen	glycogen	NN
cord-002209-xs6qigg4	327	48	-	-	HYPH
cord-002209-xs6qigg4	327	49	derived	derive	VBN
cord-002209-xs6qigg4	327	50	lactate	lactate	NN
cord-002209-xs6qigg4	327	51	from	from	IN
cord-002209-xs6qigg4	327	52	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	327	53	to	to	IN
cord-002209-xs6qigg4	327	54	axons	axon	NNS
cord-002209-xs6qigg4	327	55	via	via	IN
cord-002209-xs6qigg4	327	56	specific	specific	JJ
cord-002209-xs6qigg4	327	57	monocarboxylate	monocarboxylate	NN
cord-002209-xs6qigg4	327	58	transporters	transporter	NNS
cord-002209-xs6qigg4	327	59	supports	support	VBZ
cord-002209-xs6qigg4	327	60	mouse	mouse	NN
cord-002209-xs6qigg4	327	61	optic	optic	JJ
cord-002209-xs6qigg4	327	62	nerve	nerve	NN
cord-002209-xs6qigg4	327	63	activity	activity	NN
cord-002209-xs6qigg4	328	1	Interferon	interferon	NN
cord-002209-xs6qigg4	328	2	-	-	HYPH
cord-002209-xs6qigg4	328	3	gamma	gamma	NN
cord-002209-xs6qigg4	328	4	and	and	CC
cord-002209-xs6qigg4	328	5	Ia	Ia	NNP
cord-002209-xs6qigg4	328	6	antigen	antigen	NNP
cord-002209-xs6qigg4	328	7	are	be	VBP
cord-002209-xs6qigg4	328	8	present	present	JJ
cord-002209-xs6qigg4	328	9	on	on	IN
cord-002209-xs6qigg4	328	10	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	328	11	in	in	IN
cord-002209-xs6qigg4	328	12	active	active	JJ
cord-002209-xs6qigg4	328	13	chronic	chronic	JJ
cord-002209-xs6qigg4	328	14	multiple	multiple	JJ
cord-002209-xs6qigg4	328	15	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	328	16	lesions	lesion	NNS
cord-002209-xs6qigg4	328	17	Microglial	Microglial	NNP
cord-002209-xs6qigg4	328	18	interactions	interaction	NNS
cord-002209-xs6qigg4	328	19	with	with	IN
cord-002209-xs6qigg4	328	20	synapses	synapsis	NNS
cord-002209-xs6qigg4	328	21	are	be	VBP
cord-002209-xs6qigg4	328	22	modulated	modulate	VBN
cord-002209-xs6qigg4	328	23	by	by	IN
cord-002209-xs6qigg4	328	24	visual	visual	JJ
cord-002209-xs6qigg4	328	25	experience	experience	NN
cord-002209-xs6qigg4	329	1	Panglial	panglial	JJ
cord-002209-xs6qigg4	329	2	gap	gap	NN
cord-002209-xs6qigg4	330	1	junctional	junctional	JJ
cord-002209-xs6qigg4	330	2	communication	communication	NN
cord-002209-xs6qigg4	330	3	is	be	VBZ
cord-002209-xs6qigg4	330	4	essential	essential	JJ
cord-002209-xs6qigg4	330	5	for	for	IN
cord-002209-xs6qigg4	330	6	maintenance	maintenance	NN
cord-002209-xs6qigg4	330	7	of	of	IN
cord-002209-xs6qigg4	330	8	myelin	myelin	NN
cord-002209-xs6qigg4	330	9	in	in	IN
cord-002209-xs6qigg4	330	10	the	the	DT
cord-002209-xs6qigg4	330	11	CNS	CNS	NNP
cord-002209-xs6qigg4	330	12	Tumor	tumor	NN
cord-002209-xs6qigg4	330	13	necrosis	necrosis	NN
cord-002209-xs6qigg4	330	14	factor	factor	NN
cord-002209-xs6qigg4	330	15	and	and	CC
cord-002209-xs6qigg4	330	16	interleukin-1	interleukin-1	NN
cord-002209-xs6qigg4	330	17	in	in	IN
cord-002209-xs6qigg4	330	18	the	the	DT
cord-002209-xs6qigg4	330	19	CSF	CSF	NNP
cord-002209-xs6qigg4	330	20	and	and	CC
cord-002209-xs6qigg4	330	21	sera	sera	NNP
cord-002209-xs6qigg4	330	22	of	of	IN
cord-002209-xs6qigg4	330	23	patients	patient	NNS
cord-002209-xs6qigg4	330	24	with	with	IN
cord-002209-xs6qigg4	330	25	multiple	multiple	JJ
cord-002209-xs6qigg4	330	26	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	330	27	Histological	Histological	NNP
cord-002209-xs6qigg4	330	28	investigation	investigation	NN
cord-002209-xs6qigg4	330	29	of	of	IN
cord-002209-xs6qigg4	330	30	spinal	spinal	JJ
cord-002209-xs6qigg4	330	31	cord	cord	NN
cord-002209-xs6qigg4	330	32	lesions	lesion	NNS
cord-002209-xs6qigg4	330	33	in	in	IN
cord-002209-xs6qigg4	330	34	the	the	DT
cord-002209-xs6qigg4	330	35	spinal	spinal	JJ
cord-002209-xs6qigg4	330	36	hyperostotic	hyperostotic	JJ
cord-002209-xs6qigg4	330	37	mouse	mouse	NN
cord-002209-xs6qigg4	330	38	(	(	-LRB-
cord-002209-xs6qigg4	330	39	twy	twy	NNP
cord-002209-xs6qigg4	330	40	/	/	SYM
cord-002209-xs6qigg4	330	41	twy	twy	NN
cord-002209-xs6qigg4	330	42	)	)	-RRB-
cord-002209-xs6qigg4	330	43	:	:	:
cord-002209-xs6qigg4	330	44	morphological	morphological	JJ
cord-002209-xs6qigg4	330	45	changes	change	NNS
cord-002209-xs6qigg4	330	46	in	in	IN
cord-002209-xs6qigg4	330	47	anterior	anterior	JJ
cord-002209-xs6qigg4	330	48	horn	horn	NN
cord-002209-xs6qigg4	330	49	cells	cell	NNS
cord-002209-xs6qigg4	330	50	and	and	CC
cord-002209-xs6qigg4	330	51	immunoreactivity	immunoreactivity	NN
cord-002209-xs6qigg4	330	52	to	to	IN
cord-002209-xs6qigg4	330	53	neurotropic	neurotropic	NNP
cord-002209-xs6qigg4	330	54	factors	factor	NNS
cord-002209-xs6qigg4	330	55	Control	Control	NNP
cord-002209-xs6qigg4	330	56	of	of	IN
cord-002209-xs6qigg4	330	57	synapse	synapse	NN
cord-002209-xs6qigg4	330	58	number	number	NN
cord-002209-xs6qigg4	330	59	by	by	IN
cord-002209-xs6qigg4	330	60	glia	glia	NNP
cord-002209-xs6qigg4	330	61	Plateletderived	Plateletderived	NNP
cord-002209-xs6qigg4	330	62	growth	growth	NN
cord-002209-xs6qigg4	330	63	factor	factor	NN
cord-002209-xs6qigg4	330	64	promotes	promote	VBZ
cord-002209-xs6qigg4	330	65	repair	repair	NN
cord-002209-xs6qigg4	330	66	of	of	IN
cord-002209-xs6qigg4	330	67	chronically	chronically	RB
cord-002209-xs6qigg4	330	68	demyelinated	demyelinate	VBN
cord-002209-xs6qigg4	330	69	white	white	JJ
cord-002209-xs6qigg4	330	70	matter	matter	NN
cord-002209-xs6qigg4	330	71	Ciliary	Ciliary	NNP
cord-002209-xs6qigg4	330	72	neurotrophic	neurotrophic	JJ
cord-002209-xs6qigg4	330	73	factor	factor	NN
cord-002209-xs6qigg4	330	74	controls	control	VBZ
cord-002209-xs6qigg4	330	75	progenitor	progenitor	NN
cord-002209-xs6qigg4	330	76	migration	migration	NN
cord-002209-xs6qigg4	330	77	during	during	IN
cord-002209-xs6qigg4	330	78	remyelination	remyelination	NN
cord-002209-xs6qigg4	330	79	in	in	IN
cord-002209-xs6qigg4	330	80	the	the	DT
cord-002209-xs6qigg4	330	81	adult	adult	NN
cord-002209-xs6qigg4	330	82	rodent	rodent	NN
cord-002209-xs6qigg4	330	83	brain	brain	NN
cord-002209-xs6qigg4	330	84	Baumann	Baumann	NNP
cord-002209-xs6qigg4	330	85	N.	N.	NNP
cord-002209-xs6qigg4	330	86	Myelin	Myelin	NNP
cord-002209-xs6qigg4	330	87	-	-	HYPH
cord-002209-xs6qigg4	330	88	induced	induce	VBN
cord-002209-xs6qigg4	330	89	experimental	experimental	JJ
cord-002209-xs6qigg4	330	90	allergic	allergic	JJ
cord-002209-xs6qigg4	330	91	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	330	92	in	in	IN
cord-002209-xs6qigg4	330	93	Lewis	Lewis	NNP
cord-002209-xs6qigg4	330	94	rats	rat	NNS
cord-002209-xs6qigg4	330	95	:	:	:
cord-002209-xs6qigg4	331	1	tumor	tumor	NN
cord-002209-xs6qigg4	331	2	necrosis	necrosis	NN
cord-002209-xs6qigg4	331	3	factor	factor	NN
cord-002209-xs6qigg4	331	4	alpha	alpha	NN
cord-002209-xs6qigg4	331	5	levels	level	NNS
cord-002209-xs6qigg4	331	6	in	in	IN
cord-002209-xs6qigg4	331	7	serum	serum	NN
cord-002209-xs6qigg4	331	8	and	and	CC
cord-002209-xs6qigg4	331	9	cerebrospinal	cerebrospinal	JJ
cord-002209-xs6qigg4	331	10	fluid	fluid	JJ
cord-002209-xs6qigg4	331	11	immunohistochemical	immunohistochemical	JJ
cord-002209-xs6qigg4	331	12	expression	expression	NN
cord-002209-xs6qigg4	331	13	in	in	IN
cord-002209-xs6qigg4	331	14	glial	glial	JJ
cord-002209-xs6qigg4	331	15	cells	cell	NNS
cord-002209-xs6qigg4	331	16	and	and	CC
cord-002209-xs6qigg4	331	17	macrophages	macrophage	NNS
cord-002209-xs6qigg4	331	18	of	of	IN
cord-002209-xs6qigg4	331	19	optic	optic	JJ
cord-002209-xs6qigg4	331	20	nerve	nerve	NN
cord-002209-xs6qigg4	331	21	and	and	CC
cord-002209-xs6qigg4	331	22	spinal	spinal	JJ
cord-002209-xs6qigg4	331	23	cord	cord	NN
cord-002209-xs6qigg4	331	24	Reactive	Reactive	NNP
cord-002209-xs6qigg4	331	25	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	331	26	form	form	VBP
cord-002209-xs6qigg4	331	27	scar	scar	NN
cord-002209-xs6qigg4	331	28	-	-	HYPH
cord-002209-xs6qigg4	331	29	like	like	JJ
cord-002209-xs6qigg4	331	30	perivascular	perivascular	JJ
cord-002209-xs6qigg4	331	31	barriers	barrier	NNS
cord-002209-xs6qigg4	331	32	to	to	IN
cord-002209-xs6qigg4	331	33	leukocytes	leukocyte	NNS
cord-002209-xs6qigg4	331	34	during	during	IN
cord-002209-xs6qigg4	331	35	adoptive	adoptive	JJ
cord-002209-xs6qigg4	331	36	immune	immune	JJ
cord-002209-xs6qigg4	331	37	inflammation	inflammation	NN
cord-002209-xs6qigg4	331	38	of	of	IN
cord-002209-xs6qigg4	331	39	the	the	DT
cord-002209-xs6qigg4	331	40	CNS	CNS	NNP
cord-002209-xs6qigg4	332	1	The	the	DT
cord-002209-xs6qigg4	332	2	impact	impact	NN
cord-002209-xs6qigg4	332	3	of	of	IN
cord-002209-xs6qigg4	332	4	astrocytic	astrocytic	JJ
cord-002209-xs6qigg4	332	5	gap	gap	NN
cord-002209-xs6qigg4	332	6	junctional	junctional	JJ
cord-002209-xs6qigg4	332	7	coupling	coupling	NN
cord-002209-xs6qigg4	332	8	on	on	IN
cord-002209-xs6qigg4	332	9	potassium	potassium	NN
cord-002209-xs6qigg4	332	10	buffering	buffering	NN
cord-002209-xs6qigg4	332	11	in	in	IN
cord-002209-xs6qigg4	332	12	the	the	DT
cord-002209-xs6qigg4	332	13	hippocampus	hippocampus	NN
cord-002209-xs6qigg4	332	14	Distinct	distinct	JJ
cord-002209-xs6qigg4	332	15	stages	stage	NNS
cord-002209-xs6qigg4	332	16	of	of	IN
cord-002209-xs6qigg4	332	17	myelination	myelination	NN
cord-002209-xs6qigg4	332	18	regulated	regulate	VBN
cord-002209-xs6qigg4	332	19	by	by	IN
cord-002209-xs6qigg4	332	20	gamma	gamma	NN
cord-002209-xs6qigg4	332	21	-	-	HYPH
cord-002209-xs6qigg4	332	22	secretase	secretase	JJ
cord-002209-xs6qigg4	332	23	and	and	CC
cord-002209-xs6qigg4	332	24	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	332	25	in	in	IN
cord-002209-xs6qigg4	332	26	a	a	DT
cord-002209-xs6qigg4	332	27	rapidly	rapidly	RB
cord-002209-xs6qigg4	332	28	myelinating	myelinate	VBG
cord-002209-xs6qigg4	332	29	CNS	cns	NN
cord-002209-xs6qigg4	332	30	coculture	coculture	NN
cord-002209-xs6qigg4	332	31	system	system	NN
cord-002209-xs6qigg4	332	32	Immunocytochemical	Immunocytochemical	NNP
cord-002209-xs6qigg4	332	33	study	study	NN
cord-002209-xs6qigg4	332	34	of	of	IN
cord-002209-xs6qigg4	332	35	myelinassociated	myelinassociated	JJ
cord-002209-xs6qigg4	332	36	glycoprotein	glycoprotein	NN
cord-002209-xs6qigg4	332	37	(	(	-LRB-
cord-002209-xs6qigg4	332	38	MAG	MAG	NNP
cord-002209-xs6qigg4	332	39	)	)	-RRB-
cord-002209-xs6qigg4	332	40	,	,	,
cord-002209-xs6qigg4	332	41	basic	basic	JJ
cord-002209-xs6qigg4	332	42	protein	protein	NN
cord-002209-xs6qigg4	332	43	(	(	-LRB-
cord-002209-xs6qigg4	332	44	BP	BP	NNP
cord-002209-xs6qigg4	332	45	)	)	-RRB-
cord-002209-xs6qigg4	332	46	,	,	,
cord-002209-xs6qigg4	332	47	and	and	CC
cord-002209-xs6qigg4	332	48	glial	glial	JJ
cord-002209-xs6qigg4	332	49	fibrillary	fibrillary	JJ
cord-002209-xs6qigg4	332	50	acidic	acidic	JJ
cord-002209-xs6qigg4	332	51	protein	protein	NN
cord-002209-xs6qigg4	332	52	(	(	-LRB-
cord-002209-xs6qigg4	332	53	GFAP	GFAP	NNP
cord-002209-xs6qigg4	332	54	)	)	-RRB-
cord-002209-xs6qigg4	332	55	in	in	IN
cord-002209-xs6qigg4	332	56	chronic	chronic	JJ
cord-002209-xs6qigg4	332	57	relapsing	relapse	VBG
cord-002209-xs6qigg4	332	58	experimental	experimental	JJ
cord-002209-xs6qigg4	332	59	allergic	allergic	JJ
cord-002209-xs6qigg4	332	60	encephalomyelitis	encephalomyelitis	NN
cord-002209-xs6qigg4	332	61	(	(	-LRB-
cord-002209-xs6qigg4	332	62	EAE	EAE	NNP
cord-002209-xs6qigg4	332	63	)	)	-RRB-
cord-002209-xs6qigg4	332	64	Astrocytes	Astrocytes	NNP
cord-002209-xs6qigg4	332	65	-	-	HYPH
cord-002209-xs6qigg4	332	66	friends	friend	NNS
cord-002209-xs6qigg4	332	67	or	or	CC
cord-002209-xs6qigg4	332	68	foes	foe	NNS
cord-002209-xs6qigg4	332	69	in	in	IN
cord-002209-xs6qigg4	332	70	multiple	multiple	JJ
cord-002209-xs6qigg4	332	71	sclerosis	sclerosis	NN
cord-002209-xs6qigg4	332	72	?	?	.
cord-002209-xs6qigg4	333	1	A	a	DT
cord-002209-xs6qigg4	333	2	role	role	NN
cord-002209-xs6qigg4	333	3	for	for	IN
cord-002209-xs6qigg4	333	4	ciliary	ciliary	NN
cord-002209-xs6qigg4	333	5	neurotrophic	neurotrophic	NN
cord-002209-xs6qigg4	333	6	factor	factor	NN
cord-002209-xs6qigg4	333	7	as	as	IN
cord-002209-xs6qigg4	333	8	an	an	DT
cord-002209-xs6qigg4	333	9	inducer	inducer	NN
cord-002209-xs6qigg4	333	10	of	of	IN
cord-002209-xs6qigg4	333	11	reactive	reactive	JJ
cord-002209-xs6qigg4	333	12	gliosis	gliosis	NN
cord-002209-xs6qigg4	333	13	,	,	,
cord-002209-xs6qigg4	334	1	the	the	DT
cord-002209-xs6qigg4	334	2	glial	glial	JJ
cord-002209-xs6qigg4	334	3	response	response	NN
cord-002209-xs6qigg4	334	4	to	to	IN
cord-002209-xs6qigg4	334	5	central	central	JJ
cord-002209-xs6qigg4	334	6	nervous	nervous	JJ
cord-002209-xs6qigg4	334	7	system	system	NN
cord-002209-xs6qigg4	334	8	injury	injury	NN
cord-002209-xs6qigg4	334	9	Platelet	platelet	NN
cord-002209-xs6qigg4	334	10	-	-	HYPH
cord-002209-xs6qigg4	334	11	derived	derive	VBN
cord-002209-xs6qigg4	334	12	growth	growth	NN
cord-002209-xs6qigg4	334	13	factor	factor	NN
cord-002209-xs6qigg4	334	14	regulates	regulate	VBZ
cord-002209-xs6qigg4	334	15	oligodendrocyte	oligodendrocyte	NNP
cord-002209-xs6qigg4	334	16	progenitor	progenitor	JJ
cord-002209-xs6qigg4	334	17	numbers	number	NNS
cord-002209-xs6qigg4	334	18	in	in	IN
cord-002209-xs6qigg4	334	19	adult	adult	NN
cord-002209-xs6qigg4	334	20	CNS	CNS	NNP
cord-002209-xs6qigg4	334	21	and	and	CC
cord-002209-xs6qigg4	334	22	their	-PRON-	PRP$
cord-002209-xs6qigg4	334	23	response	response	NN
cord-002209-xs6qigg4	334	24	following	follow	VBG
cord-002209-xs6qigg4	334	25	CNS	CNS	NNP
cord-002209-xs6qigg4	334	26	demyelination	demyelination	NN
cord-002209-xs6qigg4	334	27	Microglia	Microglia	NNP
cord-002209-xs6qigg4	334	28	:	:	:
cord-002209-xs6qigg4	334	29	dynamic	dynamic	JJ
cord-002209-xs6qigg4	334	30	mediators	mediator	NNS
cord-002209-xs6qigg4	334	31	of	of	IN
cord-002209-xs6qigg4	334	32	synapse	synapse	NN
cord-002209-xs6qigg4	334	33	development	development	NN
cord-002209-xs6qigg4	334	34	and	and	CC
cord-002209-xs6qigg4	334	35	plasticity	plasticity	NN
cord-002209-xs6qigg4	334	36	Profile	profile	NN
cord-002209-xs6qigg4	334	37	and	and	CC
cord-002209-xs6qigg4	334	38	regulation	regulation	NN
cord-002209-xs6qigg4	334	39	of	of	IN
cord-002209-xs6qigg4	334	40	apolipoprotein	apolipoprotein	NN
cord-002209-xs6qigg4	334	41	E	e	NN
cord-002209-xs6qigg4	334	42	(	(	-LRB-
cord-002209-xs6qigg4	334	43	ApoE	ApoE	NNS
cord-002209-xs6qigg4	334	44	)	)	-RRB-
cord-002209-xs6qigg4	334	45	expression	expression	NN
cord-002209-xs6qigg4	334	46	in	in	IN
cord-002209-xs6qigg4	334	47	the	the	DT
cord-002209-xs6qigg4	334	48	CNS	CNS	NNP
cord-002209-xs6qigg4	334	49	in	in	IN
cord-002209-xs6qigg4	334	50	mice	mouse	NNS
cord-002209-xs6qigg4	334	51	with	with	IN
cord-002209-xs6qigg4	334	52	targeting	target	VBG
cord-002209-xs6qigg4	334	53	of	of	IN
cord-002209-xs6qigg4	334	54	green	green	JJ
cord-002209-xs6qigg4	334	55	fluorescent	fluorescent	NN
cord-002209-xs6qigg4	334	56	protein	protein	NN
cord-002209-xs6qigg4	334	57	gene	gene	NN
cord-002209-xs6qigg4	334	58	to	to	IN
cord-002209-xs6qigg4	334	59	the	the	DT
cord-002209-xs6qigg4	334	60	ApoE	ApoE	NNPS
cord-002209-xs6qigg4	334	61	locus	locus	NN
cord-002209-xs6qigg4	335	1	Possible	possible	JJ
cord-002209-xs6qigg4	335	2	involvement	involvement	NN
cord-002209-xs6qigg4	335	3	of	of	IN
cord-002209-xs6qigg4	335	4	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	335	5	in	in	IN
cord-002209-xs6qigg4	335	6	neuroprotection	neuroprotection	NN
cord-002209-xs6qigg4	335	7	by	by	IN
cord-002209-xs6qigg4	335	8	the	the	DT
cord-002209-xs6qigg4	335	9	cognitive	cognitive	JJ
cord-002209-xs6qigg4	335	10	enhancer	enhancer	NN
cord-002209-xs6qigg4	335	11	T-588	t-588	NN
cord-002209-xs6qigg4	335	12	Gamma	gamma	NN
cord-002209-xs6qigg4	335	13	-	-	HYPH
cord-002209-xs6qigg4	335	14	interferon	interferon	NN
cord-002209-xs6qigg4	335	15	promotes	promote	VBZ
cord-002209-xs6qigg4	335	16	proliferation	proliferation	NN
cord-002209-xs6qigg4	335	17	of	of	IN
cord-002209-xs6qigg4	335	18	adult	adult	NN
cord-002209-xs6qigg4	335	19	human	human	JJ
cord-002209-xs6qigg4	335	20	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	335	21	in	in	IN
cord-002209-xs6qigg4	335	22	vitro	vitro	FW
cord-002209-xs6qigg4	335	23	and	and	CC
cord-002209-xs6qigg4	335	24	reactive	reactive	JJ
cord-002209-xs6qigg4	335	25	gliosis	gliosis	NN
cord-002209-xs6qigg4	335	26	in	in	IN
cord-002209-xs6qigg4	335	27	the	the	DT
cord-002209-xs6qigg4	335	28	adult	adult	NN
cord-002209-xs6qigg4	335	29	mouse	mouse	NN
cord-002209-xs6qigg4	335	30	brain	brain	NN
cord-002209-xs6qigg4	335	31	in	in	IN
cord-002209-xs6qigg4	335	32	vivo	vivo	NNP
cord-002209-xs6qigg4	336	1	Neurotrophic	neurotrophic	JJ
cord-002209-xs6qigg4	336	2	effects	effect	NNS
cord-002209-xs6qigg4	336	3	of	of	IN
cord-002209-xs6qigg4	336	4	conditioned	condition	VBN
cord-002209-xs6qigg4	336	5	media	medium	NNS
cord-002209-xs6qigg4	336	6	of	of	IN
cord-002209-xs6qigg4	336	7	astrocytes	astrocyte	NNS
cord-002209-xs6qigg4	336	8	isolated	isolate	VBN
cord-002209-xs6qigg4	336	9	from	from	IN
cord-002209-xs6qigg4	336	10	different	different	JJ
cord-002209-xs6qigg4	336	11	brain	brain	NN
cord-002209-xs6qigg4	336	12	regions	region	NNS
cord-002209-xs6qigg4	336	13	on	on	IN
cord-002209-xs6qigg4	336	14	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	336	15	and	and	CC
cord-002209-xs6qigg4	336	16	cortical	cortical	JJ
cord-002209-xs6qigg4	336	17	neurons	neuron	NNS
cord-002209-xs6qigg4	336	18	Genomic	genomic	JJ
cord-002209-xs6qigg4	336	19	analysis	analysis	NN
cord-002209-xs6qigg4	336	20	of	of	IN
cord-002209-xs6qigg4	336	21	reactive	reactive	JJ
cord-002209-xs6qigg4	336	22	astrogliosis	astrogliosis	NN
cord-002209-xs6qigg4	336	23	Astrocyte	Astrocyte	NNP
cord-002209-xs6qigg4	336	24	-	-	HYPH
cord-002209-xs6qigg4	336	25	conditioned	condition	VBN
cord-002209-xs6qigg4	336	26	medium	medium	NN
cord-002209-xs6qigg4	336	27	protecting	protect	VBG
cord-002209-xs6qigg4	336	28	hippocampal	hippocampal	JJ
cord-002209-xs6qigg4	336	29	neurons	neuron	NNS
cord-002209-xs6qigg4	336	30	in	in	IN
cord-002209-xs6qigg4	336	31	primary	primary	JJ
cord-002209-xs6qigg4	336	32	cultures	culture	NNS
cord-002209-xs6qigg4	336	33	against	against	IN
cord-002209-xs6qigg4	336	34	corticosterone	corticosterone	NN
cord-002209-xs6qigg4	336	35	-	-	HYPH
cord-002209-xs6qigg4	336	36	induced	induce	VBN
cord-002209-xs6qigg4	336	37	damages	damage	NNS
cord-002209-xs6qigg4	336	38	via	via	IN
cord-002209-xs6qigg4	336	39	PI3-K/	pi3-k/	CD
cord-002209-xs6qigg4	337	1	Akt	Akt	NNP
cord-002209-xs6qigg4	337	2	signal	signal	NN
cord-002209-xs6qigg4	337	3	pathway	pathway	NN
cord-002209-xs6qigg4	338	1	This	this	DT
cord-002209-xs6qigg4	338	2	work	work	NN
cord-002209-xs6qigg4	338	3	was	be	VBD
cord-002209-xs6qigg4	338	4	funded	fund	VBN
cord-002209-xs6qigg4	338	5	by	by	IN
cord-002209-xs6qigg4	338	6	The	the	DT
cord-002209-xs6qigg4	338	7	Wellcome	Wellcome	NNP
cord-002209-xs6qigg4	338	8	Trust	Trust	NNP
cord-002209-xs6qigg4	338	9	(	(	-LRB-
cord-002209-xs6qigg4	338	10	HK	HK	NNP
cord-002209-xs6qigg4	338	11	,	,	,
cord-002209-xs6qigg4	338	12	WT083434	WT083434	NNP
cord-002209-xs6qigg4	338	13	)	)	-RRB-
cord-002209-xs6qigg4	338	14	,	,	,
cord-002209-xs6qigg4	338	15	Medical	Medical	NNP
cord-002209-xs6qigg4	338	16	Research	Research	NNP
cord-002209-xs6qigg4	338	17	Council	Council	NNP
cord-002209-xs6qigg4	338	18	(	(	-LRB-
cord-002209-xs6qigg4	338	19	SL	SL	NNP
cord-002209-xs6qigg4	338	20	,	,	,
cord-002209-xs6qigg4	338	21	MR	MR	NNP
cord-002209-xs6qigg4	338	22	/	/	SYM
cord-002209-xs6qigg4	338	23	J004731/1	J004731/1	NNP
cord-002209-xs6qigg4	338	24	)	)	-RRB-
cord-002209-xs6qigg4	338	25	and	and	CC
cord-002209-xs6qigg4	338	26	Medical	Medical	NNP
cord-002209-xs6qigg4	338	27	Research	Research	NNP
cord-002209-xs6qigg4	338	28	Scotland	Scotland	NNP
cord-002209-xs6qigg4	339	1	(	(	-LRB-
cord-002209-xs6qigg4	339	2	SH	SH	NNP
cord-002209-xs6qigg4	339	3	,	,	,
cord-002209-xs6qigg4	339	4	PhD-718	PhD-718	NNP
cord-002209-xs6qigg4	339	5	-	-	HYPH
cord-002209-xs6qigg4	339	6	2013	2013	CD
cord-002209-xs6qigg4	339	7	)	)	-RRB-
cord-002209-xs6qigg4	339	8	.	.	.