id	sid	tid	token	lemma	pos
cord-015021-pol2qm74	1	1	key	key	JJ
cord-015021-pol2qm74	1	2	:	:	:
cord-015021-pol2qm74	1	3	cord-015021-pol2qm74	cord-015021-pol2qm74	NN
cord-015021-pol2qm74	1	4	authors	author	NNS
cord-015021-pol2qm74	1	5	:	:	:
cord-015021-pol2qm74	2	1	nan	nan	NNP
cord-015021-pol2qm74	2	2	title	title	NN
cord-015021-pol2qm74	2	3	:	:	:
cord-015021-pol2qm74	3	1	Third	Third	NNP
cord-015021-pol2qm74	3	2	International	International	NNP
cord-015021-pol2qm74	3	3	Congress	Congress	NNP
cord-015021-pol2qm74	3	4	on	on	IN
cord-015021-pol2qm74	3	5	the	the	DT
cord-015021-pol2qm74	3	6	Immune	Immune	NNP
cord-015021-pol2qm74	3	7	Consequences	consequence	NNS
cord-015021-pol2qm74	3	8	of	of	IN
cord-015021-pol2qm74	3	9	Trauma	trauma	NN
cord-015021-pol2qm74	3	10	,	,	,
cord-015021-pol2qm74	3	11	Shock	Shock	NNP
cord-015021-pol2qm74	3	12	and	and	CC
cord-015021-pol2qm74	3	13	Sepsis	sepsis	NN
cord-015021-pol2qm74	3	14	—	—	:
cord-015021-pol2qm74	3	15	Mechanisms	mechanism	NNS
cord-015021-pol2qm74	3	16	and	and	CC
cord-015021-pol2qm74	3	17	Therapeutic	therapeutic	JJ
cord-015021-pol2qm74	3	18	Approaches	Approaches	NNP
cord-015021-pol2qm74	3	19	date	date	NN
cord-015021-pol2qm74	3	20	:	:	:
cord-015021-pol2qm74	3	21	1994	1994	CD
cord-015021-pol2qm74	3	22	journal	journal	NN
cord-015021-pol2qm74	3	23	:	:	:
cord-015021-pol2qm74	3	24	Intensive	Intensive	NNP
cord-015021-pol2qm74	3	25	Care	care	NN
cord-015021-pol2qm74	3	26	Med	Med	NNP
cord-015021-pol2qm74	3	27	DOI	doi	NN
cord-015021-pol2qm74	3	28	:	:	:
cord-015021-pol2qm74	4	1	10.1007	10.1007	CD
cord-015021-pol2qm74	4	2	/	/	SYM
cord-015021-pol2qm74	4	3	bf02258437	bf02258437	NNP
cord-015021-pol2qm74	4	4	sha	sha	NNP
cord-015021-pol2qm74	4	5	:	:	:
cord-015021-pol2qm74	5	1	a8f598af282543b2862ab62a4c671754a94c8a5e	a8f598af282543b2862ab62a4c671754a94c8a5e	NNP
cord-015021-pol2qm74	5	2	doc_id	doc_id	CD
cord-015021-pol2qm74	5	3	:	:	:
cord-015021-pol2qm74	5	4	15021	15021	CD
cord-015021-pol2qm74	5	5	cord_uid	cord_uid	FW
cord-015021-pol2qm74	5	6	:	:	:
cord-015021-pol2qm74	6	1	pol2qm74	pol2qm74	NNP
cord-015021-pol2qm74	7	1	nan	nan	NNP
cord-015021-pol2qm74	8	1	This	this	DT
cord-015021-pol2qm74	8	2	issue	issue	NN
cord-015021-pol2qm74	8	3	of	of	IN
cord-015021-pol2qm74	8	4	the	the	DT
cord-015021-pol2qm74	8	5	journal	journal	NN
cord-015021-pol2qm74	8	6	contains	contain	VBZ
cord-015021-pol2qm74	8	7	the	the	DT
cord-015021-pol2qm74	8	8	abstracts	abstract	NNS
cord-015021-pol2qm74	8	9	for	for	IN
cord-015021-pol2qm74	8	10	the	the	DT
cord-015021-pol2qm74	8	11	Third	Third	NNP
cord-015021-pol2qm74	8	12	International	International	NNP
cord-015021-pol2qm74	8	13	Congress	Congress	NNP
cord-015021-pol2qm74	8	14	on	on	IN
cord-015021-pol2qm74	8	15	the	the	DT
cord-015021-pol2qm74	8	16	Immune	Immune	NNP
cord-015021-pol2qm74	8	17	Consequences	consequence	NNS
cord-015021-pol2qm74	8	18	of	of	IN
cord-015021-pol2qm74	8	19	Trauma	trauma	NN
cord-015021-pol2qm74	8	20	,	,	,
cord-015021-pol2qm74	8	21	Shock	Shock	NNP
cord-015021-pol2qm74	8	22	and	and	CC
cord-015021-pol2qm74	8	23	Sepsis	Sepsis	NNP
cord-015021-pol2qm74	8	24	-Mechanisms	-mechanism	NNS
cord-015021-pol2qm74	8	25	and	and	CC
cord-015021-pol2qm74	8	26	Therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8	27	Approaches	approach	NNS
cord-015021-pol2qm74	8	28	.	.	.
cord-015021-pol2qm74	9	1	We	-PRON-	PRP
cord-015021-pol2qm74	9	2	hope	hope	VBP
cord-015021-pol2qm74	9	3	that	that	IN
cord-015021-pol2qm74	9	4	the	the	DT
cord-015021-pol2qm74	9	5	information	information	NN
cord-015021-pol2qm74	9	6	contained	contain	VBN
cord-015021-pol2qm74	9	7	in	in	IN
cord-015021-pol2qm74	9	8	this	this	DT
cord-015021-pol2qm74	9	9	special	special	JJ
cord-015021-pol2qm74	9	10	issue	issue	NN
cord-015021-pol2qm74	9	11	will	will	MD
cord-015021-pol2qm74	9	12	stimulate	stimulate	VB
cord-015021-pol2qm74	9	13	you	-PRON-	PRP
cord-015021-pol2qm74	9	14	to	to	TO
cord-015021-pol2qm74	9	15	participate	participate	VB
cord-015021-pol2qm74	9	16	in	in	IN
cord-015021-pol2qm74	9	17	the	the	DT
cord-015021-pol2qm74	9	18	congress	congress	NNP
cord-015021-pol2qm74	9	19	,	,	,
cord-015021-pol2qm74	9	20	to	to	TO
cord-015021-pol2qm74	9	21	contribute	contribute	VB
cord-015021-pol2qm74	9	22	to	to	IN
cord-015021-pol2qm74	9	23	the	the	DT
cord-015021-pol2qm74	9	24	knowledge	knowledge	NN
cord-015021-pol2qm74	9	25	being	be	VBG
cord-015021-pol2qm74	9	26	developed	develop	VBN
cord-015021-pol2qm74	9	27	in	in	IN
cord-015021-pol2qm74	9	28	this	this	DT
cord-015021-pol2qm74	9	29	field	field	NN
cord-015021-pol2qm74	9	30	and	and	CC
cord-015021-pol2qm74	9	31	to	to	TO
cord-015021-pol2qm74	9	32	use	use	VB
cord-015021-pol2qm74	9	33	this	this	DT
cord-015021-pol2qm74	9	34	information	information	NN
cord-015021-pol2qm74	9	35	to	to	TO
cord-015021-pol2qm74	9	36	help	help	VB
cord-015021-pol2qm74	9	37	you	-PRON-	PRP
cord-015021-pol2qm74	9	38	in	in	IN
cord-015021-pol2qm74	9	39	providing	provide	VBG
cord-015021-pol2qm74	9	40	better	well	JJR
cord-015021-pol2qm74	9	41	care	care	NN
cord-015021-pol2qm74	9	42	for	for	IN
cord-015021-pol2qm74	9	43	your	-PRON-	PRP$
cord-015021-pol2qm74	9	44	patients	patient	NNS
cord-015021-pol2qm74	9	45	.	.	.
cord-015021-pol2qm74	10	1	We	-PRON-	PRP
cord-015021-pol2qm74	10	2	thank	thank	VBP
cord-015021-pol2qm74	10	3	the	the	DT
cord-015021-pol2qm74	10	4	editors	editor	NNS
cord-015021-pol2qm74	10	5	and	and	CC
cord-015021-pol2qm74	10	6	the	the	DT
cord-015021-pol2qm74	10	7	editorial	editorial	JJ
cord-015021-pol2qm74	10	8	board	board	NN
cord-015021-pol2qm74	10	9	and	and	CC
cord-015021-pol2qm74	10	10	publishers	publisher	NNS
cord-015021-pol2qm74	10	11	of	of	IN
cord-015021-pol2qm74	10	12	the	the	DT
cord-015021-pol2qm74	10	13	journal	journal	NN
cord-015021-pol2qm74	10	14	for	for	IN
cord-015021-pol2qm74	10	15	their	-PRON-	PRP$
cord-015021-pol2qm74	10	16	interest	interest	NN
cord-015021-pol2qm74	10	17	and	and	CC
cord-015021-pol2qm74	10	18	support	support	NN
cord-015021-pol2qm74	10	19	in	in	IN
cord-015021-pol2qm74	10	20	preparation	preparation	NN
cord-015021-pol2qm74	10	21	of	of	IN
cord-015021-pol2qm74	10	22	this	this	DT
cord-015021-pol2qm74	10	23	special	special	JJ
cord-015021-pol2qm74	10	24	issue	issue	NN
cord-015021-pol2qm74	10	25	.	.	.
cord-015021-pol2qm74	11	1	We	-PRON-	PRP
cord-015021-pol2qm74	11	2	also	also	RB
cord-015021-pol2qm74	11	3	,	,	,
cord-015021-pol2qm74	11	4	on	on	IN
cord-015021-pol2qm74	11	5	behalf	behalf	NN
cord-015021-pol2qm74	11	6	of	of	IN
cord-015021-pol2qm74	11	7	the	the	DT
cord-015021-pol2qm74	11	8	scientific	scientific	JJ
cord-015021-pol2qm74	11	9	committee	committee	NN
cord-015021-pol2qm74	11	10	,	,	,
cord-015021-pol2qm74	11	11	welcome	welcome	VBP
cord-015021-pol2qm74	11	12	you	-PRON-	PRP
cord-015021-pol2qm74	11	13	to	to	IN
cord-015021-pol2qm74	11	14	the	the	DT
cord-015021-pol2qm74	11	15	Third	Third	NNP
cord-015021-pol2qm74	11	16	International	International	NNP
cord-015021-pol2qm74	11	17	Congress	Congress	NNP
cord-015021-pol2qm74	11	18	in	in	IN
cord-015021-pol2qm74	11	19	Munich	Munich	NNP
cord-015021-pol2qm74	11	20	on	on	IN
cord-015021-pol2qm74	11	21	2	2	CD
cord-015021-pol2qm74	11	22	-	-	SYM
cord-015021-pol2qm74	11	23	5	5	CD
cord-015021-pol2qm74	11	24	March	March	NNP
cord-015021-pol2qm74	11	25	1994	1994	CD
cord-015021-pol2qm74	11	26	.	.	.
cord-015021-pol2qm74	12	1	When	when	WRB
cord-015021-pol2qm74	12	2	,	,	,
cord-015021-pol2qm74	12	3	in	in	IN
cord-015021-pol2qm74	12	4	the	the	DT
cord-015021-pol2qm74	12	5	mid-1980s	mid-1980	NNS
cord-015021-pol2qm74	12	6	,	,	,
cord-015021-pol2qm74	12	7	we	-PRON-	PRP
cord-015021-pol2qm74	12	8	thought	think	VBD
cord-015021-pol2qm74	12	9	of	of	IN
cord-015021-pol2qm74	12	10	having	have	VBG
cord-015021-pol2qm74	12	11	a	a	DT
cord-015021-pol2qm74	12	12	worldwide	worldwide	JJ
cord-015021-pol2qm74	12	13	congress	congress	NNP
cord-015021-pol2qm74	12	14	,	,	,
cord-015021-pol2qm74	12	15	we	-PRON-	PRP
cord-015021-pol2qm74	12	16	hoped	hope	VBD
cord-015021-pol2qm74	12	17	to	to	TO
cord-015021-pol2qm74	12	18	bring	bring	VB
cord-015021-pol2qm74	12	19	together	together	RB
cord-015021-pol2qm74	12	20	investigators	investigator	NNS
cord-015021-pol2qm74	12	21	to	to	TO
cord-015021-pol2qm74	12	22	discuss	discuss	VB
cord-015021-pol2qm74	12	23	this	this	DT
cord-015021-pol2qm74	12	24	theme	theme	NN
cord-015021-pol2qm74	12	25	.	.	.
cord-015021-pol2qm74	13	1	The	the	DT
cord-015021-pol2qm74	13	2	explosion	explosion	NN
cord-015021-pol2qm74	13	3	of	of	IN
cord-015021-pol2qm74	13	4	knowledge	knowledge	NN
cord-015021-pol2qm74	13	5	occurring	occur	VBG
cord-015021-pol2qm74	13	6	around	around	IN
cord-015021-pol2qm74	13	7	that	that	DT
cord-015021-pol2qm74	13	8	time	time	NN
cord-015021-pol2qm74	13	9	provided	provide	VBD
cord-015021-pol2qm74	13	10	an	an	DT
cord-015021-pol2qm74	13	11	excellent	excellent	JJ
cord-015021-pol2qm74	13	12	background	background	NN
cord-015021-pol2qm74	13	13	against	against	IN
cord-015021-pol2qm74	13	14	which	which	WDT
cord-015021-pol2qm74	13	15	the	the	DT
cord-015021-pol2qm74	13	16	first	first	JJ
cord-015021-pol2qm74	13	17	conference	conference	NN
cord-015021-pol2qm74	13	18	in	in	IN
cord-015021-pol2qm74	13	19	1988	1988	CD
cord-015021-pol2qm74	13	20	provided	provide	VBN
cord-015021-pol2qm74	13	21	stateof	stateof	NN
cord-015021-pol2qm74	13	22	-	-	HYPH
cord-015021-pol2qm74	13	23	the	the	DT
cord-015021-pol2qm74	13	24	-	-	HYPH
cord-015021-pol2qm74	13	25	art	art	NN
cord-015021-pol2qm74	13	26	information	information	NN
cord-015021-pol2qm74	13	27	and	and	CC
cord-015021-pol2qm74	13	28	consensus	consensus	NN
cord-015021-pol2qm74	13	29	on	on	IN
cord-015021-pol2qm74	13	30	factors	factor	NNS
cord-015021-pol2qm74	13	31	involved	involve	VBN
cord-015021-pol2qm74	13	32	in	in	IN
cord-015021-pol2qm74	13	33	injury	injury	NN
cord-015021-pol2qm74	13	34	and	and	CC
cord-015021-pol2qm74	13	35	sepsis	sepsis	NN
cord-015021-pol2qm74	13	36	.	.	.
cord-015021-pol2qm74	14	1	In	in	IN
cord-015021-pol2qm74	14	2	1991	1991	CD
cord-015021-pol2qm74	14	3	,	,	,
cord-015021-pol2qm74	14	4	the	the	DT
cord-015021-pol2qm74	14	5	Second	Second	NNP
cord-015021-pol2qm74	14	6	Congress	Congress	NNP
cord-015021-pol2qm74	14	7	was	be	VBD
cord-015021-pol2qm74	14	8	held	hold	VBN
cord-015021-pol2qm74	14	9	at	at	IN
cord-015021-pol2qm74	14	10	the	the	DT
cord-015021-pol2qm74	14	11	time	time	NN
cord-015021-pol2qm74	14	12	of	of	IN
cord-015021-pol2qm74	14	13	another	another	DT
cord-015021-pol2qm74	14	14	resurgence	resurgence	NN
cord-015021-pol2qm74	14	15	of	of	IN
cord-015021-pol2qm74	14	16	research	research	NN
cord-015021-pol2qm74	14	17	,	,	,
cord-015021-pol2qm74	14	18	study	study	NN
cord-015021-pol2qm74	14	19	and	and	CC
cord-015021-pol2qm74	14	20	information	information	NN
cord-015021-pol2qm74	14	21	on	on	IN
cord-015021-pol2qm74	14	22	injured	injure	VBN
cord-015021-pol2qm74	14	23	and	and	CC
cord-015021-pol2qm74	14	24	operated	operate	VBN
cord-015021-pol2qm74	14	25	patients	patient	NNS
cord-015021-pol2qm74	14	26	.	.	.
cord-015021-pol2qm74	15	1	It	-PRON-	PRP
cord-015021-pol2qm74	15	2	seemed	seem	VBD
cord-015021-pol2qm74	15	3	then	then	RB
cord-015021-pol2qm74	15	4	that	that	IN
cord-015021-pol2qm74	15	5	there	there	EX
cord-015021-pol2qm74	15	6	would	would	MD
cord-015021-pol2qm74	15	7	be	be	VB
cord-015021-pol2qm74	15	8	a	a	DT
cord-015021-pol2qm74	15	9	lull	lull	NN
cord-015021-pol2qm74	15	10	in	in	IN
cord-015021-pol2qm74	15	11	the	the	DT
cord-015021-pol2qm74	15	12	development	development	NN
cord-015021-pol2qm74	15	13	of	of	IN
cord-015021-pol2qm74	15	14	new	new	JJ
cord-015021-pol2qm74	15	15	information	information	NN
cord-015021-pol2qm74	15	16	and	and	CC
cord-015021-pol2qm74	15	17	therapy	therapy	NN
cord-015021-pol2qm74	15	18	,	,	,
cord-015021-pol2qm74	15	19	and	and	CC
cord-015021-pol2qm74	15	20	that	that	IN
cord-015021-pol2qm74	15	21	another	another	DT
cord-015021-pol2qm74	15	22	state	state	NN
cord-015021-pol2qm74	15	23	-	-	HYPH
cord-015021-pol2qm74	15	24	of	of	IN
cord-015021-pol2qm74	15	25	-	-	HYPH
cord-015021-pol2qm74	15	26	the	the	DT
cord-015021-pol2qm74	15	27	art	art	NN
cord-015021-pol2qm74	15	28	conference	conference	NN
cord-015021-pol2qm74	15	29	might	may	MD
cord-015021-pol2qm74	15	30	not	not	RB
cord-015021-pol2qm74	15	31	be	be	VB
cord-015021-pol2qm74	15	32	necessary	necessary	JJ
cord-015021-pol2qm74	15	33	until	until	IN
cord-015021-pol2qm74	15	34	1995	1995	CD
cord-015021-pol2qm74	15	35	or	or	CC
cord-015021-pol2qm74	15	36	1996	1996	CD
cord-015021-pol2qm74	15	37	.	.	.
cord-015021-pol2qm74	16	1	However	however	RB
cord-015021-pol2qm74	16	2	,	,	,
cord-015021-pol2qm74	16	3	the	the	DT
cord-015021-pol2qm74	16	4	explosion	explosion	NN
cord-015021-pol2qm74	16	5	in	in	IN
cord-015021-pol2qm74	16	6	molecular	molecular	JJ
cord-015021-pol2qm74	16	7	biology	biology	NN
cord-015021-pol2qm74	16	8	has	have	VBZ
cord-015021-pol2qm74	16	9	continued	continue	VBN
cord-015021-pol2qm74	16	10	.	.	.
cord-015021-pol2qm74	17	1	The	the	DT
cord-015021-pol2qm74	17	2	wonderful	wonderful	JJ
cord-015021-pol2qm74	17	3	world	world	NN
cord-015021-pol2qm74	17	4	of	of	IN
cord-015021-pol2qm74	17	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	17	6	has	have	VBZ
cord-015021-pol2qm74	17	7	gone	go	VBN
cord-015021-pol2qm74	17	8	from	from	IN
cord-015021-pol2qm74	17	9	ILl	ILl	NNP
cord-015021-pol2qm74	17	10	to	to	IN
cord-015021-pol2qm74	17	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	17	12	to	to	IN
cord-015021-pol2qm74	17	13	IL-11	IL-11	NNP
cord-015021-pol2qm74	17	14	,	,	,
cord-015021-pol2qm74	17	15	IL-12	IL-12	NNP
cord-015021-pol2qm74	17	16	and	and	CC
cord-015021-pol2qm74	17	17	IL-13	IL-13	NNP
cord-015021-pol2qm74	17	18	and	and	CC
cord-015021-pol2qm74	17	19	beyond	beyond	IN
cord-015021-pol2qm74	17	20	.	.	.
cord-015021-pol2qm74	18	1	The	the	DT
cord-015021-pol2qm74	18	2	vast	vast	JJ
cord-015021-pol2qm74	18	3	amount	amount	NN
cord-015021-pol2qm74	18	4	of	of	IN
cord-015021-pol2qm74	18	5	information	information	NN
cord-015021-pol2qm74	18	6	about	about	IN
cord-015021-pol2qm74	18	7	mediators	mediator	NNS
cord-015021-pol2qm74	18	8	and	and	CC
cord-015021-pol2qm74	18	9	their	-PRON-	PRP$
cord-015021-pol2qm74	18	10	importance	importance	NN
cord-015021-pol2qm74	18	11	in	in	IN
cord-015021-pol2qm74	18	12	disease	disease	NN
cord-015021-pol2qm74	18	13	is	be	VBZ
cord-015021-pol2qm74	18	14	impressive	impressive	JJ
cord-015021-pol2qm74	18	15	.	.	.
cord-015021-pol2qm74	19	1	This	this	DT
cord-015021-pol2qm74	19	2	has	have	VBZ
cord-015021-pol2qm74	19	3	all	all	RB
cord-015021-pol2qm74	19	4	suggested	suggest	VBN
cord-015021-pol2qm74	19	5	a	a	DT
cord-015021-pol2qm74	19	6	magic	magic	JJ
cord-015021-pol2qm74	19	7	bullet	bullet	NN
cord-015021-pol2qm74	19	8	that	that	WDT
cord-015021-pol2qm74	19	9	might	may	MD
cord-015021-pol2qm74	19	10	be	be	VB
cord-015021-pol2qm74	19	11	used	use	VBN
cord-015021-pol2qm74	19	12	to	to	TO
cord-015021-pol2qm74	19	13	alter	alter	VB
cord-015021-pol2qm74	19	14	or	or	CC
cord-015021-pol2qm74	19	15	block	block	VB
cord-015021-pol2qm74	19	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	19	17	responses	response	NNS
cord-015021-pol2qm74	19	18	.	.	.
cord-015021-pol2qm74	20	1	This	this	DT
cord-015021-pol2qm74	20	2	has	have	VBZ
cord-015021-pol2qm74	20	3	not	not	RB
cord-015021-pol2qm74	20	4	happened	happen	VBN
cord-015021-pol2qm74	20	5	,	,	,
cord-015021-pol2qm74	20	6	however	however	RB
cord-015021-pol2qm74	20	7	,	,	,
cord-015021-pol2qm74	20	8	and	and	CC
cord-015021-pol2qm74	20	9	the	the	DT
cord-015021-pol2qm74	20	10	question	question	NN
cord-015021-pol2qm74	20	11	is	be	VBZ
cord-015021-pol2qm74	20	12	"	"	``
cord-015021-pol2qm74	20	13	Why	why	WRB
cord-015021-pol2qm74	20	14	not	not	RB
cord-015021-pol2qm74	20	15	"	"	''
cord-015021-pol2qm74	20	16	?	?	.
cord-015021-pol2qm74	21	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	21	2	science	science	NN
cord-015021-pol2qm74	21	3	is	be	VBZ
cord-015021-pol2qm74	21	4	powerful	powerful	JJ
cord-015021-pol2qm74	21	5	,	,	,
cord-015021-pol2qm74	21	6	but	but	CC
cord-015021-pol2qm74	21	7	our	-PRON-	PRP$
cord-015021-pol2qm74	21	8	therapy	therapy	NN
cord-015021-pol2qm74	21	9	is	be	VBZ
cord-015021-pol2qm74	21	10	still	still	RB
cord-015021-pol2qm74	21	11	weak	weak	JJ
cord-015021-pol2qm74	21	12	.	.	.
cord-015021-pol2qm74	22	1	What	what	WP
cord-015021-pol2qm74	22	2	are	be	VBP
cord-015021-pol2qm74	22	3	the	the	DT
cord-015021-pol2qm74	22	4	issues	issue	NNS
cord-015021-pol2qm74	22	5	,	,	,
cord-015021-pol2qm74	22	6	then	then	RB
cord-015021-pol2qm74	22	7	,	,	,
cord-015021-pol2qm74	22	8	in	in	IN
cord-015021-pol2qm74	22	9	1994	1994	CD
cord-015021-pol2qm74	22	10	,	,	,
cord-015021-pol2qm74	22	11	to	to	TO
cord-015021-pol2qm74	22	12	be	be	VB
cord-015021-pol2qm74	22	13	dealt	deal	VBN
cord-015021-pol2qm74	22	14	with	with	IN
cord-015021-pol2qm74	22	15	at	at	IN
cord-015021-pol2qm74	22	16	this	this	DT
cord-015021-pol2qm74	22	17	symposium	symposium	NN
cord-015021-pol2qm74	22	18	and	and	CC
cord-015021-pol2qm74	22	19	congress	congress	NNP
cord-015021-pol2qm74	22	20	?	?	.
cord-015021-pol2qm74	23	1	(	(	-LRB-
cord-015021-pol2qm74	23	2	1	1	LS
cord-015021-pol2qm74	23	3	)	)	-RRB-
cord-015021-pol2qm74	23	4	Proposals	proposal	NNS
cord-015021-pol2qm74	23	5	for	for	IN
cord-015021-pol2qm74	23	6	new	new	JJ
cord-015021-pol2qm74	23	7	terminology	terminology	NN
cord-015021-pol2qm74	23	8	.	.	.
cord-015021-pol2qm74	24	1	There	there	EX
cord-015021-pol2qm74	24	2	have	have	VBP
cord-015021-pol2qm74	24	3	been	be	VBN
cord-015021-pol2qm74	24	4	a	a	DT
cord-015021-pol2qm74	24	5	number	number	NN
cord-015021-pol2qm74	24	6	of	of	IN
cord-015021-pol2qm74	24	7	proposals	proposal	NNS
cord-015021-pol2qm74	24	8	for	for	IN
cord-015021-pol2qm74	24	9	new	new	JJ
cord-015021-pol2qm74	24	10	terminology	terminology	NN
cord-015021-pol2qm74	24	11	and	and	CC
cord-015021-pol2qm74	24	12	new	new	JJ
cord-015021-pol2qm74	24	13	classifications	classification	NNS
cord-015021-pol2qm74	24	14	of	of	IN
cord-015021-pol2qm74	24	15	injury	injury	NN
cord-015021-pol2qm74	24	16	,	,	,
cord-015021-pol2qm74	24	17	sepsis	sepsis	NN
cord-015021-pol2qm74	24	18	,	,	,
cord-015021-pol2qm74	24	19	inflammation	inflammation	NN
cord-015021-pol2qm74	24	20	and	and	CC
cord-015021-pol2qm74	24	21	various	various	JJ
cord-015021-pol2qm74	24	22	other	other	JJ
cord-015021-pol2qm74	24	23	problems	problem	NNS
cord-015021-pol2qm74	24	24	related	relate	VBN
cord-015021-pol2qm74	24	25	to	to	IN
cord-015021-pol2qm74	24	26	human	human	JJ
cord-015021-pol2qm74	24	27	illness	illness	NN
cord-015021-pol2qm74	24	28	.	.	.
cord-015021-pol2qm74	25	1	The	the	DT
cord-015021-pol2qm74	25	2	question	question	NN
cord-015021-pol2qm74	25	3	is	be	VBZ
cord-015021-pol2qm74	25	4	whether	whether	IN
cord-015021-pol2qm74	25	5	this	this	DT
cord-015021-pol2qm74	25	6	is	be	VBZ
cord-015021-pol2qm74	25	7	the	the	DT
cord-015021-pol2qm74	25	8	way	way	NN
cord-015021-pol2qm74	25	9	to	to	TO
cord-015021-pol2qm74	25	10	go	go	VB
cord-015021-pol2qm74	25	11	.	.	.
cord-015021-pol2qm74	26	1	Will	Will	MD
cord-015021-pol2qm74	26	2	this	this	DT
cord-015021-pol2qm74	26	3	contribute	contribute	VB
cord-015021-pol2qm74	26	4	to	to	IN
cord-015021-pol2qm74	26	5	better	well	JJR
cord-015021-pol2qm74	26	6	clinical	clinical	JJ
cord-015021-pol2qm74	26	7	trials	trial	NNS
cord-015021-pol2qm74	26	8	,	,	,
cord-015021-pol2qm74	26	9	information	information	NN
cord-015021-pol2qm74	26	10	basis	basis	NN
cord-015021-pol2qm74	26	11	and	and	CC
cord-015021-pol2qm74	26	12	better	well	JJR
cord-015021-pol2qm74	26	13	research	research	NN
cord-015021-pol2qm74	26	14	?	?	.
cord-015021-pol2qm74	27	1	The	the	DT
cord-015021-pol2qm74	27	2	pros	pro	NNS
cord-015021-pol2qm74	27	3	and	and	CC
cord-015021-pol2qm74	27	4	cons	con	NNS
cord-015021-pol2qm74	27	5	of	of	IN
cord-015021-pol2qm74	27	6	this	this	DT
cord-015021-pol2qm74	27	7	development	development	NN
cord-015021-pol2qm74	27	8	will	will	MD
cord-015021-pol2qm74	27	9	be	be	VB
cord-015021-pol2qm74	27	10	reviewed	review	VBN
cord-015021-pol2qm74	27	11	by	by	IN
cord-015021-pol2qm74	27	12	those	those	DT
cord-015021-pol2qm74	27	13	making	make	VBG
cord-015021-pol2qm74	27	14	the	the	DT
cord-015021-pol2qm74	27	15	proposals	proposal	NNS
cord-015021-pol2qm74	27	16	and	and	CC
cord-015021-pol2qm74	27	17	those	those	DT
cord-015021-pol2qm74	27	18	questioning	question	VBG
cord-015021-pol2qm74	27	19	the	the	DT
cord-015021-pol2qm74	27	20	need	need	NN
cord-015021-pol2qm74	27	21	for	for	IN
cord-015021-pol2qm74	27	22	and	and	CC
cord-015021-pol2qm74	27	23	wisdom	wisdom	NN
cord-015021-pol2qm74	27	24	of	of	IN
cord-015021-pol2qm74	27	25	this	this	DT
cord-015021-pol2qm74	27	26	effort	effort	NN
cord-015021-pol2qm74	27	27	.	.	.
cord-015021-pol2qm74	28	1	(	(	-LRB-
cord-015021-pol2qm74	28	2	2	2	LS
cord-015021-pol2qm74	28	3	)	)	-RRB-
cord-015021-pol2qm74	28	4	Magic	magic	JJ
cord-015021-pol2qm74	28	5	bullets	bullet	NNS
cord-015021-pol2qm74	28	6	:	:	:
cord-015021-pol2qm74	28	7	the	the	DT
cord-015021-pol2qm74	28	8	prospect	prospect	NN
cord-015021-pol2qm74	28	9	of	of	IN
cord-015021-pol2qm74	28	10	a	a	DT
cord-015021-pol2qm74	28	11	magic	magic	JJ
cord-015021-pol2qm74	28	12	bullet	bullet	NN
cord-015021-pol2qm74	28	13	to	to	TO
cord-015021-pol2qm74	28	14	deal	deal	VB
cord-015021-pol2qm74	28	15	with	with	IN
cord-015021-pol2qm74	28	16	inflammation	inflammation	NN
cord-015021-pol2qm74	28	17	in	in	IN
cord-015021-pol2qm74	28	18	injury	injury	NN
cord-015021-pol2qm74	28	19	and	and	CC
cord-015021-pol2qm74	28	20	infection	infection	NN
cord-015021-pol2qm74	28	21	seemed	seem	VBD
cord-015021-pol2qm74	28	22	highly	highly	RB
cord-015021-pol2qm74	28	23	promising	promising	JJ
cord-015021-pol2qm74	28	24	earlier	early	RBR
cord-015021-pol2qm74	28	25	.	.	.
cord-015021-pol2qm74	29	1	Many	many	JJ
cord-015021-pol2qm74	29	2	preclinical	preclinical	JJ
cord-015021-pol2qm74	29	3	trials	trial	NNS
cord-015021-pol2qm74	29	4	and	and	CC
cord-015021-pol2qm74	29	5	a	a	DT
cord-015021-pol2qm74	29	6	lot	lot	NN
cord-015021-pol2qm74	29	7	of	of	IN
cord-015021-pol2qm74	29	8	animal	animal	NN
cord-015021-pol2qm74	29	9	research	research	NN
cord-015021-pol2qm74	29	10	suggested	suggest	VBD
cord-015021-pol2qm74	29	11	the	the	DT
cord-015021-pol2qm74	29	12	possibility	possibility	NN
cord-015021-pol2qm74	29	13	of	of	IN
cord-015021-pol2qm74	29	14	a	a	DT
cord-015021-pol2qm74	29	15	great	great	JJ
cord-015021-pol2qm74	29	16	breakthrough	breakthrough	NN
cord-015021-pol2qm74	29	17	in	in	IN
cord-015021-pol2qm74	29	18	clinical	clinical	JJ
cord-015021-pol2qm74	29	19	care	care	NN
cord-015021-pol2qm74	29	20	.	.	.
cord-015021-pol2qm74	30	1	What	what	WP
cord-015021-pol2qm74	30	2	has	have	VBZ
cord-015021-pol2qm74	30	3	become	become	VBN
cord-015021-pol2qm74	30	4	,	,	,
cord-015021-pol2qm74	30	5	then	then	RB
cord-015021-pol2qm74	30	6	,	,	,
cord-015021-pol2qm74	30	7	of	of	IN
cord-015021-pol2qm74	30	8	all	all	PDT
cord-015021-pol2qm74	30	9	the	the	DT
cord-015021-pol2qm74	30	10	expensive	expensive	JJ
cord-015021-pol2qm74	30	11	and	and	CC
cord-015021-pol2qm74	30	12	extensive	extensive	JJ
cord-015021-pol2qm74	30	13	multi	multi	JJ
cord-015021-pol2qm74	30	14	-	-	NN
cord-015021-pol2qm74	30	15	institution	institution	NN
cord-015021-pol2qm74	30	16	randomized	randomize	VBN
cord-015021-pol2qm74	30	17	,	,	,
cord-015021-pol2qm74	30	18	placebo	placebo	NN
cord-015021-pol2qm74	30	19	-	-	HYPH
cord-015021-pol2qm74	30	20	controlled	control	VBN
cord-015021-pol2qm74	30	21	,	,	,
cord-015021-pol2qm74	30	22	double	double	JJ
cord-015021-pol2qm74	30	23	-	-	HYPH
cord-015021-pol2qm74	30	24	blind	blind	JJ
cord-015021-pol2qm74	30	25	clinical	clinical	JJ
cord-015021-pol2qm74	30	26	trials	trial	NNS
cord-015021-pol2qm74	30	27	of	of	IN
cord-015021-pol2qm74	30	28	agents	agent	NNS
cord-015021-pol2qm74	30	29	that	that	WDT
cord-015021-pol2qm74	30	30	block	block	VBP
cord-015021-pol2qm74	30	31	mediators	mediator	NNS
cord-015021-pol2qm74	30	32	and	and	CC
cord-015021-pol2qm74	30	33	endotoxin	endotoxin	NN
cord-015021-pol2qm74	30	34	.	.	.
cord-015021-pol2qm74	31	1	Many	many	JJ
cord-015021-pol2qm74	31	2	such	such	JJ
cord-015021-pol2qm74	31	3	studies	study	NNS
cord-015021-pol2qm74	31	4	have	have	VBP
cord-015021-pol2qm74	31	5	yielded	yield	VBN
cord-015021-pol2qm74	31	6	equivocal	equivocal	JJ
cord-015021-pol2qm74	31	7	,	,	,
cord-015021-pol2qm74	31	8	marginal	marginal	JJ
cord-015021-pol2qm74	31	9	or	or	CC
cord-015021-pol2qm74	31	10	negative	negative	JJ
cord-015021-pol2qm74	31	11	results	result	NNS
cord-015021-pol2qm74	31	12	.	.	.
cord-015021-pol2qm74	32	1	The	the	DT
cord-015021-pol2qm74	32	2	reasons	reason	NNS
cord-015021-pol2qm74	32	3	for	for	IN
cord-015021-pol2qm74	32	4	this	this	DT
cord-015021-pol2qm74	32	5	and	and	CC
cord-015021-pol2qm74	32	6	the	the	DT
cord-015021-pol2qm74	32	7	future	future	NN
cord-015021-pol2qm74	32	8	of	of	IN
cord-015021-pol2qm74	32	9	clinical	clinical	JJ
cord-015021-pol2qm74	32	10	research	research	NN
cord-015021-pol2qm74	32	11	will	will	MD
cord-015021-pol2qm74	32	12	be	be	VB
cord-015021-pol2qm74	32	13	the	the	DT
cord-015021-pol2qm74	32	14	subject	subject	NN
cord-015021-pol2qm74	32	15	of	of	IN
cord-015021-pol2qm74	32	16	presentations	presentation	NNS
cord-015021-pol2qm74	32	17	and	and	CC
cord-015021-pol2qm74	32	18	discussions	discussion	NNS
cord-015021-pol2qm74	32	19	to	to	TO
cord-015021-pol2qm74	32	20	set	set	VB
cord-015021-pol2qm74	32	21	the	the	DT
cord-015021-pol2qm74	32	22	stage	stage	NN
cord-015021-pol2qm74	32	23	for	for	IN
cord-015021-pol2qm74	32	24	further	further	JJ
cord-015021-pol2qm74	32	25	work	work	NN
cord-015021-pol2qm74	32	26	.	.	.
cord-015021-pol2qm74	33	1	(	(	-LRB-
cord-015021-pol2qm74	33	2	3	3	LS
cord-015021-pol2qm74	33	3	)	)	-RRB-
cord-015021-pol2qm74	33	4	Should	Should	MD
cord-015021-pol2qm74	33	5	future	future	VB
cord-015021-pol2qm74	33	6	clinical	clinical	JJ
cord-015021-pol2qm74	33	7	trials	trial	NNS
cord-015021-pol2qm74	33	8	be	be	VB
cord-015021-pol2qm74	33	9	based	base	VBN
cord-015021-pol2qm74	33	10	on	on	IN
cord-015021-pol2qm74	33	11	new	new	JJ
cord-015021-pol2qm74	33	12	classifications	classification	NNS
cord-015021-pol2qm74	33	13	of	of	IN
cord-015021-pol2qm74	33	14	illness	illness	NN
cord-015021-pol2qm74	33	15	such	such	JJ
cord-015021-pol2qm74	33	16	as	as	IN
cord-015021-pol2qm74	33	17	MODS	MODS	NNP
cord-015021-pol2qm74	33	18	,	,	,
cord-015021-pol2qm74	33	19	SIRS	SIRS	NNP
cord-015021-pol2qm74	33	20	,	,	,
cord-015021-pol2qm74	33	21	APACHE	APACHE	NNP
cord-015021-pol2qm74	33	22	III	III	NNP
cord-015021-pol2qm74	33	23	,	,	,
cord-015021-pol2qm74	33	24	SAP	SAP	NNP
cord-015021-pol2qm74	33	25	II	II	NNP
cord-015021-pol2qm74	33	26	,	,	,
cord-015021-pol2qm74	33	27	MRM	MRM	NNP
cord-015021-pol2qm74	33	28	,	,	,
cord-015021-pol2qm74	33	29	etc	etc	FW
cord-015021-pol2qm74	33	30	.	.	FW
cord-015021-pol2qm74	33	31	,	,	,
cord-015021-pol2qm74	33	32	or	or	CC
cord-015021-pol2qm74	33	33	should	should	MD
cord-015021-pol2qm74	33	34	trials	trial	NNS
cord-015021-pol2qm74	33	35	be	be	VB
cord-015021-pol2qm74	33	36	dedicated	dedicated	JJ
cord-015021-pol2qm74	33	37	to	to	IN
cord-015021-pol2qm74	33	38	specific	specific	JJ
cord-015021-pol2qm74	33	39	diseases	disease	NNS
cord-015021-pol2qm74	33	40	-urinary	-urinary	JJ
cord-015021-pol2qm74	33	41	tract	tract	JJ
cord-015021-pol2qm74	33	42	infections	infection	NNS
cord-015021-pol2qm74	33	43	,	,	,
cord-015021-pol2qm74	33	44	pneumonia	pneumonia	NN
cord-015021-pol2qm74	33	45	,	,	,
cord-015021-pol2qm74	33	46	trauma	trauma	NN
cord-015021-pol2qm74	33	47	patients	patient	NNS
cord-015021-pol2qm74	33	48	,	,	,
cord-015021-pol2qm74	33	49	cardiac	cardiac	JJ
cord-015021-pol2qm74	33	50	surgery	surgery	NN
cord-015021-pol2qm74	33	51	and	and	CC
cord-015021-pol2qm74	33	52	other	other	JJ
cord-015021-pol2qm74	33	53	specific	specific	JJ
cord-015021-pol2qm74	33	54	problems	problem	NNS
cord-015021-pol2qm74	33	55	,	,	,
cord-015021-pol2qm74	33	56	rather	rather	RB
cord-015021-pol2qm74	33	57	than	than	IN
cord-015021-pol2qm74	33	58	generalized	generalized	JJ
cord-015021-pol2qm74	33	59	problems	problem	NNS
cord-015021-pol2qm74	33	60	of	of	IN
cord-015021-pol2qm74	33	61	sepsis	sepsis	NN
cord-015021-pol2qm74	33	62	,	,	,
cord-015021-pol2qm74	33	63	the	the	DT
cord-015021-pol2qm74	33	64	sepsis	sepsis	NN
cord-015021-pol2qm74	33	65	syndrome	syndrome	NN
cord-015021-pol2qm74	33	66	and	and	CC
cord-015021-pol2qm74	33	67	other	other	JJ
cord-015021-pol2qm74	33	68	classifications	classification	NNS
cord-015021-pol2qm74	33	69	?	?	.
cord-015021-pol2qm74	34	1	In	in	IN
cord-015021-pol2qm74	34	2	other	other	JJ
cord-015021-pol2qm74	34	3	words	word	NNS
cord-015021-pol2qm74	34	4	,	,	,
cord-015021-pol2qm74	34	5	should	should	MD
cord-015021-pol2qm74	34	6	we	-PRON-	PRP
cord-015021-pol2qm74	34	7	now	now	RB
cord-015021-pol2qm74	34	8	begin	begin	VB
cord-015021-pol2qm74	34	9	to	to	TO
cord-015021-pol2qm74	34	10	have	have	VB
cord-015021-pol2qm74	34	11	clinical	clinical	JJ
cord-015021-pol2qm74	34	12	trials	trial	NNS
cord-015021-pol2qm74	34	13	on	on	IN
cord-015021-pol2qm74	34	14	specific	specific	JJ
cord-015021-pol2qm74	34	15	diseases	disease	NNS
cord-015021-pol2qm74	34	16	with	with	IN
cord-015021-pol2qm74	34	17	causes	cause	NNS
cord-015021-pol2qm74	34	18	that	that	WDT
cord-015021-pol2qm74	34	19	are	be	VBP
cord-015021-pol2qm74	34	20	known	know	VBN
cord-015021-pol2qm74	34	21	and	and	CC
cord-015021-pol2qm74	34	22	can	can	MD
cord-015021-pol2qm74	34	23	be	be	VB
cord-015021-pol2qm74	34	24	attacked	attack	VBN
cord-015021-pol2qm74	34	25	?	?	.
cord-015021-pol2qm74	35	1	The	the	DT
cord-015021-pol2qm74	35	2	causality	causality	NN
cord-015021-pol2qm74	35	3	of	of	IN
cord-015021-pol2qm74	35	4	disease	disease	NN
cord-015021-pol2qm74	35	5	becomes	become	VBZ
cord-015021-pol2qm74	35	6	an	an	DT
cord-015021-pol2qm74	35	7	important	important	JJ
cord-015021-pol2qm74	35	8	consideration	consideration	NN
cord-015021-pol2qm74	35	9	in	in	IN
cord-015021-pol2qm74	35	10	this	this	DT
cord-015021-pol2qm74	35	11	regard	regard	NN
cord-015021-pol2qm74	35	12	.	.	.
cord-015021-pol2qm74	36	1	(	(	-LRB-
cord-015021-pol2qm74	36	2	4	4	LS
cord-015021-pol2qm74	36	3	)	)	-RRB-
cord-015021-pol2qm74	37	1	A	a	DT
cord-015021-pol2qm74	37	2	multitude	multitude	NN
cord-015021-pol2qm74	37	3	of	of	IN
cord-015021-pol2qm74	37	4	potential	potential	JJ
cord-015021-pol2qm74	37	5	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	37	6	agents	agent	NNS
cord-015021-pol2qm74	37	7	has	have	VBZ
cord-015021-pol2qm74	37	8	been	be	VBN
cord-015021-pol2qm74	37	9	proposed	propose	VBN
cord-015021-pol2qm74	37	10	on	on	IN
cord-015021-pol2qm74	37	11	the	the	DT
cord-015021-pol2qm74	37	12	basis	basis	NN
cord-015021-pol2qm74	37	13	of	of	IN
cord-015021-pol2qm74	37	14	animal	animal	NN
cord-015021-pol2qm74	37	15	studies	study	NNS
cord-015021-pol2qm74	37	16	.	.	.
cord-015021-pol2qm74	38	1	How	how	WRB
cord-015021-pol2qm74	38	2	should	should	MD
cord-015021-pol2qm74	38	3	we	-PRON-	PRP
cord-015021-pol2qm74	38	4	decide	decide	VB
cord-015021-pol2qm74	38	5	which	which	WDT
cord-015021-pol2qm74	38	6	of	of	IN
cord-015021-pol2qm74	38	7	them	-PRON-	PRP
cord-015021-pol2qm74	38	8	should	should	MD
cord-015021-pol2qm74	38	9	be	be	VB
cord-015021-pol2qm74	38	10	brought	bring	VBN
cord-015021-pol2qm74	38	11	to	to	IN
cord-015021-pol2qm74	38	12	clinical	clinical	JJ
cord-015021-pol2qm74	38	13	trial	trial	NN
cord-015021-pol2qm74	38	14	?	?	.
cord-015021-pol2qm74	39	1	The	the	DT
cord-015021-pol2qm74	39	2	possibilities	possibility	NNS
cord-015021-pol2qm74	39	3	are	be	VBP
cord-015021-pol2qm74	39	4	endless	endless	JJ
cord-015021-pol2qm74	39	5	as	as	IN
cord-015021-pol2qm74	39	6	we	-PRON-	PRP
cord-015021-pol2qm74	39	7	develop	develop	VBP
cord-015021-pol2qm74	39	8	new	new	JJ
cord-015021-pol2qm74	39	9	clinical	clinical	JJ
cord-015021-pol2qm74	39	10	information	information	NN
cord-015021-pol2qm74	39	11	about	about	IN
cord-015021-pol2qm74	39	12	the	the	DT
cord-015021-pol2qm74	39	13	mechanisms	mechanism	NNS
cord-015021-pol2qm74	39	14	and	and	CC
cord-015021-pol2qm74	39	15	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	39	16	of	of	IN
cord-015021-pol2qm74	39	17	human	human	JJ
cord-015021-pol2qm74	39	18	disease	disease	NN
cord-015021-pol2qm74	39	19	.	.	.
cord-015021-pol2qm74	40	1	(	(	-LRB-
cord-015021-pol2qm74	40	2	5	5	LS
cord-015021-pol2qm74	40	3	)	)	-RRB-
cord-015021-pol2qm74	40	4	Information	information	NN
cord-015021-pol2qm74	40	5	on	on	IN
cord-015021-pol2qm74	40	6	the	the	DT
cord-015021-pol2qm74	40	7	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	40	8	mechanism	mechanism	NN
cord-015021-pol2qm74	40	9	of	of	IN
cord-015021-pol2qm74	40	10	disease	disease	NN
cord-015021-pol2qm74	40	11	states	state	NNS
cord-015021-pol2qm74	40	12	and	and	CC
cord-015021-pol2qm74	40	13	of	of	IN
cord-015021-pol2qm74	40	14	injury	injury	NN
cord-015021-pol2qm74	40	15	continued	continue	VBD
cord-015021-pol2qm74	40	16	to	to	TO
cord-015021-pol2qm74	40	17	emerge	emerge	VB
cord-015021-pol2qm74	40	18	in	in	IN
cord-015021-pol2qm74	40	19	an	an	DT
cord-015021-pol2qm74	40	20	explosive	explosive	JJ
cord-015021-pol2qm74	40	21	fashion	fashion	NN
cord-015021-pol2qm74	40	22	,	,	,
cord-015021-pol2qm74	40	23	and	and	CC
cord-015021-pol2qm74	40	24	in	in	IN
cord-015021-pol2qm74	40	25	light	light	NN
cord-015021-pol2qm74	40	26	of	of	IN
cord-015021-pol2qm74	40	27	our	-PRON-	PRP$
cord-015021-pol2qm74	40	28	gathering	gathering	NN
cord-015021-pol2qm74	40	29	knowledge	knowledge	NN
cord-015021-pol2qm74	40	30	we	-PRON-	PRP
cord-015021-pol2qm74	40	31	can	can	MD
cord-015021-pol2qm74	40	32	look	look	VB
cord-015021-pol2qm74	40	33	forward	forward	RB
cord-015021-pol2qm74	40	34	to	to	IN
cord-015021-pol2qm74	40	35	working	work	VBG
cord-015021-pol2qm74	40	36	out	out	RP
cord-015021-pol2qm74	40	37	a	a	DT
cord-015021-pol2qm74	40	38	cohesive	cohesive	JJ
cord-015021-pol2qm74	40	39	system	system	NN
cord-015021-pol2qm74	40	40	of	of	IN
cord-015021-pol2qm74	40	41	response	response	NN
cord-015021-pol2qm74	40	42	to	to	IN
cord-015021-pol2qm74	40	43	injury	injury	NN
cord-015021-pol2qm74	40	44	.	.	.
cord-015021-pol2qm74	41	1	(	(	-LRB-
cord-015021-pol2qm74	41	2	6	6	CD
cord-015021-pol2qm74	41	3	)	)	-RRB-
cord-015021-pol2qm74	42	1	Additional	additional	JJ
cord-015021-pol2qm74	42	2	information	information	NN
cord-015021-pol2qm74	42	3	will	will	MD
cord-015021-pol2qm74	42	4	be	be	VB
cord-015021-pol2qm74	42	5	provided	provide	VBN
cord-015021-pol2qm74	42	6	in	in	IN
cord-015021-pol2qm74	42	7	plenary	plenary	JJ
cord-015021-pol2qm74	42	8	sections	section	NNS
cord-015021-pol2qm74	42	9	,	,	,
cord-015021-pol2qm74	42	10	many	many	JJ
cord-015021-pol2qm74	42	11	symposia	symposium	NNS
cord-015021-pol2qm74	42	12	and	and	CC
cord-015021-pol2qm74	42	13	free	free	JJ
cord-015021-pol2qm74	42	14	communication	communication	NN
cord-015021-pol2qm74	42	15	sessions	session	NNS
cord-015021-pol2qm74	42	16	and	and	CC
cord-015021-pol2qm74	42	17	posters	poster	NNS
cord-015021-pol2qm74	42	18	,	,	,
cord-015021-pol2qm74	42	19	which	which	WDT
cord-015021-pol2qm74	42	20	will	will	MD
cord-015021-pol2qm74	42	21	update	update	VB
cord-015021-pol2qm74	42	22	the	the	DT
cord-015021-pol2qm74	42	23	participants	participant	NNS
cord-015021-pol2qm74	42	24	on	on	IN
cord-015021-pol2qm74	42	25	a	a	DT
cord-015021-pol2qm74	42	26	variety	variety	NN
cord-015021-pol2qm74	42	27	of	of	IN
cord-015021-pol2qm74	42	28	relevant	relevant	JJ
cord-015021-pol2qm74	42	29	topics	topic	NNS
cord-015021-pol2qm74	42	30	presented	present	VBN
cord-015021-pol2qm74	42	31	by	by	IN
cord-015021-pol2qm74	42	32	many	many	JJ
cord-015021-pol2qm74	42	33	of	of	IN
cord-015021-pol2qm74	42	34	the	the	DT
cord-015021-pol2qm74	42	35	leading	lead	VBG
cord-015021-pol2qm74	42	36	in	in	IN
cord-015021-pol2qm74	42	37	-	-	HYPH
cord-015021-pol2qm74	42	38	IV	IV	NNP
cord-015021-pol2qm74	42	39	vestigators	vestigator	NNS
cord-015021-pol2qm74	42	40	in	in	IN
cord-015021-pol2qm74	42	41	these	these	DT
cord-015021-pol2qm74	42	42	fields	field	NNS
cord-015021-pol2qm74	42	43	.	.	.
cord-015021-pol2qm74	43	1	Topics	topic	NNS
cord-015021-pol2qm74	43	2	will	will	MD
cord-015021-pol2qm74	43	3	range	range	VB
cord-015021-pol2qm74	43	4	from	from	IN
cord-015021-pol2qm74	43	5	molecular	molecular	JJ
cord-015021-pol2qm74	43	6	mechanisms	mechanism	NNS
cord-015021-pol2qm74	43	7	,	,	,
cord-015021-pol2qm74	43	8	such	such	JJ
cord-015021-pol2qm74	43	9	as	as	IN
cord-015021-pol2qm74	43	10	signal	signal	NN
cord-015021-pol2qm74	43	11	transduction	transduction	NN
cord-015021-pol2qm74	43	12	,	,	,
cord-015021-pol2qm74	43	13	through	through	IN
cord-015021-pol2qm74	43	14	the	the	DT
cord-015021-pol2qm74	43	15	explosive	explosive	JJ
cord-015021-pol2qm74	43	16	growth	growth	NN
cord-015021-pol2qm74	43	17	of	of	IN
cord-015021-pol2qm74	43	18	information	information	NN
cord-015021-pol2qm74	43	19	on	on	IN
cord-015021-pol2qm74	43	20	the	the	DT
cord-015021-pol2qm74	43	21	role	role	NN
cord-015021-pol2qm74	43	22	of	of	IN
cord-015021-pol2qm74	43	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	43	24	and	and	CC
cord-015021-pol2qm74	43	25	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	43	26	,	,	,
cord-015021-pol2qm74	43	27	to	to	IN
cord-015021-pol2qm74	43	28	practical	practical	JJ
cord-015021-pol2qm74	43	29	considerations	consideration	NNS
cord-015021-pol2qm74	43	30	in	in	IN
cord-015021-pol2qm74	43	31	the	the	DT
cord-015021-pol2qm74	43	32	design	design	NN
cord-015021-pol2qm74	43	33	of	of	IN
cord-015021-pol2qm74	43	34	immunomodulatory	immunomodulatory	JJ
cord-015021-pol2qm74	43	35	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	43	36	regimens	regimen	NNS
cord-015021-pol2qm74	43	37	.	.	.
cord-015021-pol2qm74	44	1	These	these	DT
cord-015021-pol2qm74	44	2	merely	merely	RB
cord-015021-pol2qm74	44	3	touch	touch	VBP
cord-015021-pol2qm74	44	4	on	on	IN
cord-015021-pol2qm74	44	5	a	a	DT
cord-015021-pol2qm74	44	6	few	few	JJ
cord-015021-pol2qm74	44	7	areas	area	NNS
cord-015021-pol2qm74	44	8	,	,	,
cord-015021-pol2qm74	44	9	from	from	IN
cord-015021-pol2qm74	44	10	the	the	DT
cord-015021-pol2qm74	44	11	basic	basic	JJ
cord-015021-pol2qm74	44	12	to	to	IN
cord-015021-pol2qm74	44	13	the	the	DT
cord-015021-pol2qm74	44	14	clinical	clinical	JJ
cord-015021-pol2qm74	44	15	,	,	,
cord-015021-pol2qm74	44	16	which	which	WDT
cord-015021-pol2qm74	44	17	will	will	MD
cord-015021-pol2qm74	44	18	be	be	VB
cord-015021-pol2qm74	44	19	the	the	DT
cord-015021-pol2qm74	44	20	subjects	subject	NNS
cord-015021-pol2qm74	44	21	of	of	IN
cord-015021-pol2qm74	44	22	those	those	DT
cord-015021-pol2qm74	44	23	symposia	symposium	NNS
cord-015021-pol2qm74	44	24	.	.	.
cord-015021-pol2qm74	45	1	All	all	PDT
cord-015021-pol2qm74	45	2	this	this	DT
cord-015021-pol2qm74	45	3	information	information	NN
cord-015021-pol2qm74	45	4	will	will	MD
cord-015021-pol2qm74	45	5	fit	fit	VB
cord-015021-pol2qm74	45	6	into	into	IN
cord-015021-pol2qm74	45	7	the	the	DT
cord-015021-pol2qm74	45	8	jigsaw	jigsaw	NN
cord-015021-pol2qm74	45	9	of	of	IN
cord-015021-pol2qm74	45	10	this	this	DT
cord-015021-pol2qm74	45	11	exciting	exciting	JJ
cord-015021-pol2qm74	45	12	area	area	NN
cord-015021-pol2qm74	45	13	and	and	CC
cord-015021-pol2qm74	45	14	its	-PRON-	PRP$
cord-015021-pol2qm74	45	15	stimulus	stimulus	NN
cord-015021-pol2qm74	45	16	to	to	TO
cord-015021-pol2qm74	45	17	further	further	JJ
cord-015021-pol2qm74	45	18	research	research	NN
cord-015021-pol2qm74	45	19	study	study	NN
cord-015021-pol2qm74	45	20	.	.	.
cord-015021-pol2qm74	46	1	This	this	DT
cord-015021-pol2qm74	46	2	promises	promise	VBZ
cord-015021-pol2qm74	46	3	to	to	TO
cord-015021-pol2qm74	46	4	provide	provide	VB
cord-015021-pol2qm74	46	5	an	an	DT
cord-015021-pol2qm74	46	6	exciting	exciting	JJ
cord-015021-pol2qm74	46	7	,	,	,
cord-015021-pol2qm74	46	8	educational	educational	JJ
cord-015021-pol2qm74	46	9	programme	programme	NN
cord-015021-pol2qm74	46	10	with	with	IN
cord-015021-pol2qm74	46	11	experts	expert	NNS
cord-015021-pol2qm74	46	12	and	and	CC
cord-015021-pol2qm74	46	13	participants	participant	NNS
cord-015021-pol2qm74	46	14	from	from	IN
cord-015021-pol2qm74	46	15	all	all	RB
cord-015021-pol2qm74	46	16	over	over	IN
cord-015021-pol2qm74	46	17	the	the	DT
cord-015021-pol2qm74	46	18	world	world	NN
cord-015021-pol2qm74	46	19	.	.	.
cord-015021-pol2qm74	47	1	We	-PRON-	PRP
cord-015021-pol2qm74	47	2	hope	hope	VBP
cord-015021-pol2qm74	47	3	it	-PRON-	PRP
cord-015021-pol2qm74	47	4	will	will	MD
cord-015021-pol2qm74	47	5	set	set	VB
cord-015021-pol2qm74	47	6	the	the	DT
cord-015021-pol2qm74	47	7	stage	stage	NN
cord-015021-pol2qm74	47	8	for	for	IN
cord-015021-pol2qm74	47	9	many	many	JJ
cord-015021-pol2qm74	47	10	years	year	NNS
cord-015021-pol2qm74	47	11	to	to	TO
cord-015021-pol2qm74	47	12	come	come	VB
cord-015021-pol2qm74	47	13	and	and	CC
cord-015021-pol2qm74	47	14	will	will	MD
cord-015021-pol2qm74	47	15	increase	increase	VB
cord-015021-pol2qm74	47	16	our	-PRON-	PRP$
cord-015021-pol2qm74	47	17	understanding	understanding	NN
cord-015021-pol2qm74	47	18	of	of	IN
cord-015021-pol2qm74	47	19	trauma	trauma	NN
cord-015021-pol2qm74	47	20	,	,	,
cord-015021-pol2qm74	47	21	shock	shock	NN
cord-015021-pol2qm74	47	22	and	and	CC
cord-015021-pol2qm74	47	23	sepsis	sepsis	NN
cord-015021-pol2qm74	47	24	and	and	CC
cord-015021-pol2qm74	47	25	help	help	VB
cord-015021-pol2qm74	47	26	us	-PRON-	PRP
cord-015021-pol2qm74	47	27	to	to	TO
cord-015021-pol2qm74	47	28	provide	provide	VB
cord-015021-pol2qm74	47	29	better	well	JJR
cord-015021-pol2qm74	47	30	therapy	therapy	NN
cord-015021-pol2qm74	47	31	for	for	IN
cord-015021-pol2qm74	47	32	those	those	DT
cord-015021-pol2qm74	47	33	of	of	IN
cord-015021-pol2qm74	47	34	our	-PRON-	PRP$
cord-015021-pol2qm74	47	35	patients	patient	NNS
cord-015021-pol2qm74	47	36	who	who	WP
cord-015021-pol2qm74	47	37	are	be	VBP
cord-015021-pol2qm74	47	38	affected	affect	VBN
cord-015021-pol2qm74	47	39	by	by	IN
cord-015021-pol2qm74	47	40	such	such	JJ
cord-015021-pol2qm74	47	41	problems	problem	NNS
cord-015021-pol2qm74	47	42	.	.	.
cord-015021-pol2qm74	48	1	A.	A.	NNP
cord-015021-pol2qm74	49	1	The	the	DT
cord-015021-pol2qm74	49	2	clinical	clinical	JJ
cord-015021-pol2qm74	49	3	syndrome	syndrome	NN
cord-015021-pol2qm74	49	4	of	of	IN
cord-015021-pol2qm74	49	5	MODS	MODS	NNP
cord-015021-pol2qm74	49	6	versus	versus	IN
cord-015021-pol2qm74	49	7	MOF	MOF	NNP
cord-015021-pol2qm74	49	8	will	will	MD
cord-015021-pol2qm74	49	9	be	be	VB
cord-015021-pol2qm74	49	10	reviewed	review	VBN
cord-015021-pol2qm74	49	11	in	in	IN
cord-015021-pol2qm74	49	12	detail	detail	NN
cord-015021-pol2qm74	49	13	by	by	IN
cord-015021-pol2qm74	49	14	those	those	DT
cord-015021-pol2qm74	49	15	who	who	WP
cord-015021-pol2qm74	49	16	have	have	VBP
cord-015021-pol2qm74	49	17	made	make	VBN
cord-015021-pol2qm74	49	18	these	these	DT
cord-015021-pol2qm74	49	19	proposals	proposal	NNS
cord-015021-pol2qm74	49	20	.	.	.
cord-015021-pol2qm74	50	1	B.	B.	NNP
cord-015021-pol2qm74	51	1	An	an	DT
cord-015021-pol2qm74	51	2	extensive	extensive	JJ
cord-015021-pol2qm74	51	3	review	review	NN
cord-015021-pol2qm74	51	4	of	of	IN
cord-015021-pol2qm74	51	5	the	the	DT
cord-015021-pol2qm74	51	6	design	design	NN
cord-015021-pol2qm74	51	7	and	and	CC
cord-015021-pol2qm74	51	8	interpretation	interpretation	NN
cord-015021-pol2qm74	51	9	of	of	IN
cord-015021-pol2qm74	51	10	clinical	clinical	JJ
cord-015021-pol2qm74	51	11	trials	trial	NNS
cord-015021-pol2qm74	51	12	in	in	IN
cord-015021-pol2qm74	51	13	patients	patient	NNS
cord-015021-pol2qm74	51	14	with	with	IN
cord-015021-pol2qm74	51	15	shock	shock	NN
cord-015021-pol2qm74	51	16	and	and	CC
cord-015021-pol2qm74	51	17	injury	injury	NN
cord-015021-pol2qm74	51	18	will	will	MD
cord-015021-pol2qm74	51	19	be	be	VB
cord-015021-pol2qm74	51	20	provided	provide	VBN
cord-015021-pol2qm74	51	21	.	.	.
cord-015021-pol2qm74	52	1	The	the	DT
cord-015021-pol2qm74	52	2	reasons	reason	NNS
cord-015021-pol2qm74	52	3	why	why	WRB
cord-015021-pol2qm74	52	4	so	so	RB
cord-015021-pol2qm74	52	5	many	many	JJ
cord-015021-pol2qm74	52	6	clinical	clinical	JJ
cord-015021-pol2qm74	52	7	studies	study	NNS
cord-015021-pol2qm74	52	8	in	in	IN
cord-015021-pol2qm74	52	9	the	the	DT
cord-015021-pol2qm74	52	10	recent	recent	JJ
cord-015021-pol2qm74	52	11	past	past	NN
cord-015021-pol2qm74	52	12	have	have	VBP
cord-015021-pol2qm74	52	13	been	be	VBN
cord-015021-pol2qm74	52	14	negative	negative	JJ
cord-015021-pol2qm74	52	15	will	will	MD
cord-015021-pol2qm74	52	16	be	be	VB
cord-015021-pol2qm74	52	17	reviewed	review	VBN
cord-015021-pol2qm74	52	18	.	.	.
cord-015021-pol2qm74	53	1	The	the	DT
cord-015021-pol2qm74	53	2	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	53	3	strategies	strategy	NNS
cord-015021-pol2qm74	53	4	that	that	WDT
cord-015021-pol2qm74	53	5	are	be	VBP
cord-015021-pol2qm74	53	6	being	be	VBG
cord-015021-pol2qm74	53	7	developed	develop	VBN
cord-015021-pol2qm74	53	8	for	for	IN
cord-015021-pol2qm74	53	9	the	the	DT
cord-015021-pol2qm74	53	10	treatment	treatment	NN
cord-015021-pol2qm74	53	11	or	or	CC
cord-015021-pol2qm74	53	12	prevention	prevention	NN
cord-015021-pol2qm74	53	13	of	of	IN
cord-015021-pol2qm74	53	14	MODS	MODS	NNP
cord-015021-pol2qm74	53	15	or	or	CC
cord-015021-pol2qm74	53	16	MOF	MOF	NNP
cord-015021-pol2qm74	53	17	will	will	MD
cord-015021-pol2qm74	53	18	be	be	VB
cord-015021-pol2qm74	53	19	the	the	DT
cord-015021-pol2qm74	53	20	subject	subject	NN
cord-015021-pol2qm74	53	21	of	of	IN
cord-015021-pol2qm74	53	22	another	another	DT
cord-015021-pol2qm74	53	23	panel	panel	NN
cord-015021-pol2qm74	53	24	discussion	discussion	NN
cord-015021-pol2qm74	53	25	by	by	IN
cord-015021-pol2qm74	53	26	experts	expert	NNS
cord-015021-pol2qm74	53	27	who	who	WP
cord-015021-pol2qm74	53	28	have	have	VBP
cord-015021-pol2qm74	53	29	been	be	VBN
cord-015021-pol2qm74	53	30	involved	involve	VBN
cord-015021-pol2qm74	53	31	in	in	IN
cord-015021-pol2qm74	53	32	and	and	CC
cord-015021-pol2qm74	53	33	contributed	contribute	VBD
cord-015021-pol2qm74	53	34	to	to	IN
cord-015021-pol2qm74	53	35	this	this	DT
cord-015021-pol2qm74	53	36	area	area	NN
cord-015021-pol2qm74	53	37	.	.	.
cord-015021-pol2qm74	54	1	A	a	DT
cord-015021-pol2qm74	54	2	consensus	consensus	NN
cord-015021-pol2qm74	54	3	conference	conference	NN
cord-015021-pol2qm74	54	4	or	or	CC
cord-015021-pol2qm74	54	5	controversy	controversy	NN
cord-015021-pol2qm74	54	6	conference	conference	NN
cord-015021-pol2qm74	54	7	will	will	MD
cord-015021-pol2qm74	54	8	be	be	VB
cord-015021-pol2qm74	54	9	presented	present	VBN
cord-015021-pol2qm74	54	10	about	about	IN
cord-015021-pol2qm74	54	11	various	various	JJ
cord-015021-pol2qm74	54	12	aspects	aspect	NNS
cord-015021-pol2qm74	54	13	of	of	IN
cord-015021-pol2qm74	54	14	MODS	mod	NNS
cord-015021-pol2qm74	54	15	or	or	CC
cord-015021-pol2qm74	54	16	MOF	MOF	NNP
cord-015021-pol2qm74	54	17	,	,	,
cord-015021-pol2qm74	54	18	including	include	VBG
cord-015021-pol2qm74	54	19	the	the	DT
cord-015021-pol2qm74	54	20	benefits	benefit	NNS
cord-015021-pol2qm74	54	21	of	of	IN
cord-015021-pol2qm74	54	22	supernormal	supernormal	JJ
cord-015021-pol2qm74	54	23	oxygen	oxygen	NN
cord-015021-pol2qm74	54	24	delivery	delivery	NN
cord-015021-pol2qm74	54	25	,	,	,
cord-015021-pol2qm74	54	26	bacterial	bacterial	JJ
cord-015021-pol2qm74	54	27	translocation	translocation	NN
cord-015021-pol2qm74	54	28	,	,	,
cord-015021-pol2qm74	54	29	parenteral	parenteral	JJ
cord-015021-pol2qm74	54	30	nutrition	nutrition	NN
cord-015021-pol2qm74	54	31	,	,	,
cord-015021-pol2qm74	54	32	the	the	DT
cord-015021-pol2qm74	54	33	immune	immune	JJ
cord-015021-pol2qm74	54	34	response	response	NN
cord-015021-pol2qm74	54	35	and	and	CC
cord-015021-pol2qm74	54	36	other	other	JJ
cord-015021-pol2qm74	54	37	aspects	aspect	NNS
cord-015021-pol2qm74	54	38	.	.	.
cord-015021-pol2qm74	55	1	The	the	DT
cord-015021-pol2qm74	55	2	successes	success	NNS
cord-015021-pol2qm74	55	3	and	and	CC
cord-015021-pol2qm74	55	4	failures	failure	NNS
cord-015021-pol2qm74	55	5	of	of	IN
cord-015021-pol2qm74	55	6	completed	complete	VBN
cord-015021-pol2qm74	55	7	clinical	clinical	JJ
cord-015021-pol2qm74	55	8	trials	trial	NNS
cord-015021-pol2qm74	55	9	will	will	MD
cord-015021-pol2qm74	55	10	be	be	VB
cord-015021-pol2qm74	55	11	presented	present	VBN
cord-015021-pol2qm74	55	12	by	by	IN
cord-015021-pol2qm74	55	13	those	those	DT
cord-015021-pol2qm74	55	14	who	who	WP
cord-015021-pol2qm74	55	15	are	be	VBP
cord-015021-pol2qm74	55	16	involved	involve	VBN
cord-015021-pol2qm74	55	17	in	in	IN
cord-015021-pol2qm74	55	18	these	these	DT
cord-015021-pol2qm74	55	19	clinical	clinical	JJ
cord-015021-pol2qm74	55	20	trials	trial	NNS
cord-015021-pol2qm74	55	21	,	,	,
cord-015021-pol2qm74	55	22	with	with	IN
cord-015021-pol2qm74	55	23	a	a	DT
cord-015021-pol2qm74	55	24	refreshing	refreshing	JJ
cord-015021-pol2qm74	55	25	review	review	NN
cord-015021-pol2qm74	55	26	of	of	IN
cord-015021-pol2qm74	55	27	the	the	DT
cord-015021-pol2qm74	55	28	problems	problem	NNS
cord-015021-pol2qm74	55	29	related	relate	VBN
cord-015021-pol2qm74	55	30	to	to	IN
cord-015021-pol2qm74	55	31	that	that	DT
cord-015021-pol2qm74	55	32	injury	injury	NN
cord-015021-pol2qm74	55	33	.	.	.
cord-015021-pol2qm74	56	1	There	there	EX
cord-015021-pol2qm74	56	2	will	will	MD
cord-015021-pol2qm74	56	3	be	be	VB
cord-015021-pol2qm74	56	4	late	late	JJ
cord-015021-pol2qm74	56	5	news	news	NN
cord-015021-pol2qm74	56	6	about	about	IN
cord-015021-pol2qm74	56	7	studies	study	NNS
cord-015021-pol2qm74	56	8	just	just	RB
cord-015021-pol2qm74	56	9	being	be	VBG
cord-015021-pol2qm74	56	10	completed	complete	VBN
cord-015021-pol2qm74	56	11	at	at	IN
cord-015021-pol2qm74	56	12	present	present	JJ
cord-015021-pol2qm74	56	13	or	or	CC
cord-015021-pol2qm74	56	14	after	after	IN
cord-015021-pol2qm74	56	15	the	the	DT
cord-015021-pol2qm74	56	16	beginning	beginning	NN
cord-015021-pol2qm74	56	17	of	of	IN
cord-015021-pol2qm74	56	18	1994	1994	CD
cord-015021-pol2qm74	56	19	and	and	CC
cord-015021-pol2qm74	56	20	where	where	WRB
cord-015021-pol2qm74	56	21	they	-PRON-	PRP
cord-015021-pol2qm74	56	22	stand	stand	VBP
cord-015021-pol2qm74	56	23	.	.	.
cord-015021-pol2qm74	57	1	C.	C.	NNP
cord-015021-pol2qm74	58	1	The	the	DT
cord-015021-pol2qm74	58	2	mechanisms	mechanism	NNS
cord-015021-pol2qm74	58	3	and	and	CC
cord-015021-pol2qm74	58	4	biochemical	biochemical	JJ
cord-015021-pol2qm74	58	5	profiles	profile	NNS
cord-015021-pol2qm74	58	6	of	of	IN
cord-015021-pol2qm74	58	7	specific	specific	JJ
cord-015021-pol2qm74	58	8	organ	organ	NN
cord-015021-pol2qm74	58	9	dysfunction	dysfunction	NN
cord-015021-pol2qm74	58	10	or	or	CC
cord-015021-pol2qm74	58	11	failure	failure	NN
cord-015021-pol2qm74	58	12	will	will	MD
cord-015021-pol2qm74	58	13	be	be	VB
cord-015021-pol2qm74	58	14	reviewed	review	VBN
cord-015021-pol2qm74	58	15	.	.	.
cord-015021-pol2qm74	59	1	What	what	WP
cord-015021-pol2qm74	59	2	are	be	VBP
cord-015021-pol2qm74	59	3	the	the	DT
cord-015021-pol2qm74	59	4	definitions	definition	NNS
cord-015021-pol2qm74	59	5	?	?	.
cord-015021-pol2qm74	60	1	What	what	WP
cord-015021-pol2qm74	60	2	are	be	VBP
cord-015021-pol2qm74	60	3	the	the	DT
cord-015021-pol2qm74	60	4	mechanisms	mechanism	NNS
cord-015021-pol2qm74	60	5	?	?	.
cord-015021-pol2qm74	61	1	How	how	WRB
cord-015021-pol2qm74	61	2	can	can	MD
cord-015021-pol2qm74	61	3	organ	organ	NN
cord-015021-pol2qm74	61	4	dysfunction	dysfunction	NN
cord-015021-pol2qm74	61	5	and/or	and/or	CC
cord-015021-pol2qm74	61	6	failure	failure	NN
cord-015021-pol2qm74	61	7	be	be	VB
cord-015021-pol2qm74	61	8	defined	define	VBN
cord-015021-pol2qm74	61	9	?	?	.
cord-015021-pol2qm74	62	1	An	an	DT
cord-015021-pol2qm74	62	2	extensive	extensive	JJ
cord-015021-pol2qm74	62	3	review	review	NN
cord-015021-pol2qm74	62	4	of	of	IN
cord-015021-pol2qm74	62	5	the	the	DT
cord-015021-pol2qm74	62	6	biological	biological	JJ
cord-015021-pol2qm74	62	7	mechanisms	mechanism	NNS
cord-015021-pol2qm74	62	8	involved	involve	VBN
cord-015021-pol2qm74	62	9	in	in	IN
cord-015021-pol2qm74	62	10	production	production	NN
cord-015021-pol2qm74	62	11	of	of	IN
cord-015021-pol2qm74	62	12	injury	injury	NN
cord-015021-pol2qm74	62	13	by	by	IN
cord-015021-pol2qm74	62	14	mediators	mediator	NNS
cord-015021-pol2qm74	62	15	will	will	MD
cord-015021-pol2qm74	62	16	be	be	VB
cord-015021-pol2qm74	62	17	presented	present	VBN
cord-015021-pol2qm74	62	18	.	.	.
cord-015021-pol2qm74	63	1	A	a	DT
cord-015021-pol2qm74	63	2	session	session	NN
cord-015021-pol2qm74	63	3	will	will	MD
cord-015021-pol2qm74	63	4	be	be	VB
cord-015021-pol2qm74	63	5	devoted	devote	VBN
cord-015021-pol2qm74	63	6	to	to	IN
cord-015021-pol2qm74	63	7	how	how	WRB
cord-015021-pol2qm74	63	8	future	future	JJ
cord-015021-pol2qm74	63	9	ongoing	ongoing	JJ
cord-015021-pol2qm74	63	10	trials	trial	NNS
cord-015021-pol2qm74	63	11	might	may	MD
cord-015021-pol2qm74	63	12	be	be	VB
cord-015021-pol2qm74	63	13	better	well	RBR
cord-015021-pol2qm74	63	14	designed	design	VBN
cord-015021-pol2qm74	63	15	and	and	CC
cord-015021-pol2qm74	63	16	what	what	WP
cord-015021-pol2qm74	63	17	can	can	MD
cord-015021-pol2qm74	63	18	be	be	VB
cord-015021-pol2qm74	63	19	done	do	VBN
cord-015021-pol2qm74	63	20	about	about	IN
cord-015021-pol2qm74	63	21	the	the	DT
cord-015021-pol2qm74	63	22	studies	study	NNS
cord-015021-pol2qm74	63	23	recently	recently	RB
cord-015021-pol2qm74	63	24	completed	complete	VBD
cord-015021-pol2qm74	63	25	,	,	,
cord-015021-pol2qm74	63	26	many	many	JJ
cord-015021-pol2qm74	63	27	of	of	IN
cord-015021-pol2qm74	63	28	which	which	WDT
cord-015021-pol2qm74	63	29	are	be	VBP
cord-015021-pol2qm74	63	30	negative	negative	JJ
cord-015021-pol2qm74	63	31	.	.	.
cord-015021-pol2qm74	64	1	D.	D.	NNP
cord-015021-pol2qm74	65	1	The	the	DT
cord-015021-pol2qm74	65	2	immunological	immunological	JJ
cord-015021-pol2qm74	65	3	or	or	CC
cord-015021-pol2qm74	65	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	65	5	pathways	pathway	NNS
cord-015021-pol2qm74	65	6	resulting	result	VBG
cord-015021-pol2qm74	65	7	in	in	IN
cord-015021-pol2qm74	65	8	organ	organ	NN
cord-015021-pol2qm74	65	9	injury	injury	NN
cord-015021-pol2qm74	65	10	will	will	MD
cord-015021-pol2qm74	65	11	be	be	VB
cord-015021-pol2qm74	65	12	reviewed	review	VBN
cord-015021-pol2qm74	65	13	in	in	IN
cord-015021-pol2qm74	65	14	detail	detail	NN
cord-015021-pol2qm74	65	15	in	in	IN
cord-015021-pol2qm74	65	16	presentations	presentation	NNS
cord-015021-pol2qm74	65	17	and	and	CC
cord-015021-pol2qm74	65	18	a	a	DT
cord-015021-pol2qm74	65	19	panel	panel	NN
cord-015021-pol2qm74	65	20	discussion	discussion	NN
cord-015021-pol2qm74	65	21	.	.	.
cord-015021-pol2qm74	66	1	We	-PRON-	PRP
cord-015021-pol2qm74	66	2	look	look	VBP
cord-015021-pol2qm74	66	3	forward	forward	RB
cord-015021-pol2qm74	66	4	to	to	IN
cord-015021-pol2qm74	66	5	welcoming	welcome	VBG
cord-015021-pol2qm74	66	6	you	-PRON-	PRP
cord-015021-pol2qm74	66	7	to	to	IN
cord-015021-pol2qm74	66	8	an	an	DT
cord-015021-pol2qm74	66	9	exciting	exciting	JJ
cord-015021-pol2qm74	66	10	and	and	CC
cord-015021-pol2qm74	66	11	rewarding	rewarding	JJ
cord-015021-pol2qm74	66	12	conference	conference	NN
cord-015021-pol2qm74	66	13	,	,	,
cord-015021-pol2qm74	66	14	which	which	WDT
cord-015021-pol2qm74	66	15	undoubtedly	undoubtedly	RB
cord-015021-pol2qm74	66	16	possesses	possess	VBZ
cord-015021-pol2qm74	66	17	the	the	DT
cord-015021-pol2qm74	66	18	potential	potential	NN
cord-015021-pol2qm74	66	19	to	to	TO
cord-015021-pol2qm74	66	20	become	become	VB
cord-015021-pol2qm74	66	21	a	a	DT
cord-015021-pol2qm74	66	22	landmark	landmark	JJ
cord-015021-pol2qm74	66	23	event	event	NN
cord-015021-pol2qm74	66	24	and	and	CC
cord-015021-pol2qm74	66	25	major	major	JJ
cord-015021-pol2qm74	66	26	reference	reference	NN
cord-015021-pol2qm74	66	27	point	point	NN
cord-015021-pol2qm74	66	28	for	for	IN
cord-015021-pol2qm74	66	29	any	any	DT
cord-015021-pol2qm74	66	30	scientific	scientific	JJ
cord-015021-pol2qm74	66	31	discussion	discussion	NN
cord-015021-pol2qm74	66	32	about	about	IN
cord-015021-pol2qm74	66	33	the	the	DT
cord-015021-pol2qm74	66	34	complex	complex	NN
cord-015021-pol2qm74	66	35	of	of	IN
cord-015021-pol2qm74	66	36	host	host	NN
cord-015021-pol2qm74	66	37	defense	defense	NN
cord-015021-pol2qm74	66	38	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	66	39	following	follow	VBG
cord-015021-pol2qm74	66	40	trauma	trauma	NN
cord-015021-pol2qm74	66	41	,	,	,
cord-015021-pol2qm74	66	42	shock	shock	NN
cord-015021-pol2qm74	66	43	and	and	CC
cord-015021-pol2qm74	66	44	sepsis	sepsis	NN
cord-015021-pol2qm74	66	45	.	.	.
cord-015021-pol2qm74	67	1	Studies	study	NNS
cord-015021-pol2qm74	67	2	over	over	IN
cord-015021-pol2qm74	67	3	the	the	DT
cord-015021-pol2qm74	67	4	past	past	JJ
cord-015021-pol2qm74	67	5	25	25	CD
cord-015021-pol2qm74	67	6	years	year	NNS
cord-015021-pol2qm74	67	7	have	have	VBP
cord-015021-pol2qm74	67	8	established	establish	VBN
cord-015021-pol2qm74	67	9	that	that	IN
cord-015021-pol2qm74	67	10	the	the	DT
cord-015021-pol2qm74	67	11	contact	contact	NN
cord-015021-pol2qm74	67	12	system	system	NN
cord-015021-pol2qm74	67	13	,	,	,
cord-015021-pol2qm74	67	14	which	which	WDT
cord-015021-pol2qm74	67	15	forms	form	VBZ
cord-015021-pol2qm74	67	16	bradykin/~	bradykin/~	CD
cord-015021-pol2qm74	67	17	,	,	,
cord-015021-pol2qm74	67	18	is	be	VBZ
cord-015021-pol2qm74	67	19	gax	gax	NNP
cord-015021-pol2qm74	67	20	important	important	JJ
cord-015021-pol2qm74	67	21	mediator	mediator	NN
cord-015021-pol2qm74	67	22	in	in	IN
cord-015021-pol2qm74	67	23	hypotensive	hypotensive	JJ
cord-015021-pol2qm74	67	24	septicemia	septicemia	NN
cord-015021-pol2qm74	67	25	.	.	.
cord-015021-pol2qm74	68	1	In	in	IN
cord-015021-pol2qm74	68	2	addition	addition	NN
cord-015021-pol2qm74	68	3	to	to	IN
cord-015021-pol2qm74	68	4	hradyk{nln	hradyk{nln	NN
cord-015021-pol2qm74	68	5	,	,	,
cord-015021-pol2qm74	68	6	another	another	DT
cord-015021-pol2qm74	68	7	product	product	NN
cord-015021-pol2qm74	68	8	of	of	IN
cord-015021-pol2qm74	68	9	the	the	DT
cord-015021-pol2qm74	68	10	contact	contact	NN
cord-015021-pol2qm74	68	11	system	system	NN
cord-015021-pol2qm74	68	12	,	,	,
cord-015021-pol2qm74	68	13	kaIlikrein	kaIlikrein	NNP
cord-015021-pol2qm74	68	14	,	,	,
cord-015021-pol2qm74	68	15	can	can	MD
cord-015021-pol2qm74	68	16	mediate	mediate	VB
cord-015021-pol2qm74	68	17	inflammation	inflammation	NN
cord-015021-pol2qm74	68	18	by	by	IN
cord-015021-pol2qm74	68	19	virtue	virtue	NN
cord-015021-pol2qm74	68	20	of	of	IN
cord-015021-pol2qm74	68	21	its	-PRON-	PRP$
cord-015021-pol2qm74	68	22	chemotaetic	chemotaetic	JJ
cord-015021-pol2qm74	68	23	mad	mad	JJ
cord-015021-pol2qm74	68	24	neutrophJ	neutrophJ	NNP
cord-015021-pol2qm74	68	25	/	/	SYM
cord-015021-pol2qm74	68	26	activating	activate	VBG
cord-015021-pol2qm74	68	27	properties	property	NNS
cord-015021-pol2qm74	68	28	.	.	.
cord-015021-pol2qm74	69	1	Using	use	VBG
cord-015021-pol2qm74	69	2	functional	functional	JJ
cord-015021-pol2qm74	69	3	and	and	CC
cord-015021-pol2qm74	69	4	immunochemical	immunochemical	JJ
cord-015021-pol2qm74	69	5	tech~2ques	tech~2ques	NNP
cord-015021-pol2qm74	69	6	,	,	,
cord-015021-pol2qm74	69	7	we	-PRON-	PRP
cord-015021-pol2qm74	69	8	have	have	VBP
cord-015021-pol2qm74	69	9	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	69	10	activation	activation	NN
cord-015021-pol2qm74	69	11	of	of	IN
cord-015021-pol2qm74	69	12	the	the	DT
cord-015021-pol2qm74	69	13	contact	contact	NN
cord-015021-pol2qm74	69	14	system	system	NN
cord-015021-pol2qm74	69	15	in	in	IN
cord-015021-pol2qm74	69	16	the	the	DT
cord-015021-pol2qm74	69	17	adult	adult	NN
cord-015021-pol2qm74	69	18	respiratory	respiratory	JJ
cord-015021-pol2qm74	69	19	distress	distress	NN
cord-015021-pol2qm74	69	20	syndrome	syndrome	NN
cord-015021-pol2qm74	69	21	in	in	IN
cord-015021-pol2qm74	69	22	typhoid	typhoid	NN
cord-015021-pol2qm74	69	23	fever	fever	NN
cord-015021-pol2qm74	69	24	and	and	CC
cord-015021-pol2qm74	69	25	clin	clin	NNP
cord-015021-pol2qm74	69	26	/	/	SYM
cord-015021-pol2qm74	69	27	cal	cal	NN
cord-015021-pol2qm74	69	28	sepsis	sepsis	NN
cord-015021-pol2qm74	69	29	.	.	.
cord-015021-pol2qm74	70	1	We	-PRON-	PRP
cord-015021-pol2qm74	70	2	have	have	VBP
cord-015021-pol2qm74	70	3	also	also	RB
cord-015021-pol2qm74	70	4	been	be	VBN
cord-015021-pol2qm74	70	5	able	able	JJ
cord-015021-pol2qm74	70	6	to	to	TO
cord-015021-pol2qm74	70	7	inhibit	inhibit	VB
cord-015021-pol2qm74	70	8	the	the	DT
cord-015021-pol2qm74	70	9	hypotension	hypotension	NN
cord-015021-pol2qm74	70	10	but	but	CC
cord-015021-pol2qm74	70	11	not	not	RB
cord-015021-pol2qm74	70	12	the	the	DT
cord-015021-pol2qm74	70	13	disseminated	disseminate	VBN
cord-015021-pol2qm74	70	14	intravaseular	intravaseular	JJ
cord-015021-pol2qm74	70	15	coagulation	coagulation	NN
cord-015021-pol2qm74	70	16	in	in	IN
cord-015021-pol2qm74	70	17	a	a	DT
cord-015021-pol2qm74	70	18	model	model	NN
cord-015021-pol2qm74	70	19	of	of	IN
cord-015021-pol2qm74	70	20	primate	primate	JJ
cord-015021-pol2qm74	70	21	sepsis	sepsis	NN
cord-015021-pol2qm74	70	22	by	by	IN
cord-015021-pol2qm74	70	23	the	the	DT
cord-015021-pol2qm74	70	24	use	use	NN
cord-015021-pol2qm74	70	25	of	of	IN
cord-015021-pol2qm74	70	26	a	a	DT
cord-015021-pol2qm74	70	27	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	70	28	antibody	antibody	NN
cord-015021-pol2qm74	70	29	directed	direct	VBD
cord-015021-pol2qm74	70	30	agsi	agsi	NNP
cord-015021-pol2qm74	70	31	~	~	NFP
cord-015021-pol2qm74	70	32	st	st	NNP
cord-015021-pol2qm74	70	33	factor	factor	NNP
cord-015021-pol2qm74	70	34	XII	XII	NNP
cord-015021-pol2qm74	70	35	,	,	,
cord-015021-pol2qm74	70	36	the	the	DT
cord-015021-pol2qm74	70	37	initiating	initiate	VBG
cord-015021-pol2qm74	70	38	protein	protein	NN
cord-015021-pol2qm74	70	39	of	of	IN
cord-015021-pol2qm74	70	40	the	the	DT
cord-015021-pol2qm74	70	41	contact	contact	NN
cord-015021-pol2qm74	70	42	system	system	NN
cord-015021-pol2qm74	70	43	,	,	,
cord-015021-pol2qm74	70	44	in	in	IN
cord-015021-pol2qm74	70	45	volunteers	volunteer	NNS
cord-015021-pol2qm74	70	46	given	give	VBN
cord-015021-pol2qm74	70	47	E.	E.	NNP
cord-015021-pol2qm74	70	48	coil	coil	NN
cord-015021-pol2qm74	70	49	endotoxin	endotoxin	NN
cord-015021-pol2qm74	70	50	,	,	,
cord-015021-pol2qm74	70	51	who	who	WP
cord-015021-pol2qm74	70	52	did	do	VBD
cord-015021-pol2qm74	70	53	not	not	RB
cord-015021-pol2qm74	70	54	develop	develop	VB
cord-015021-pol2qm74	70	55	hypotension	hypotension	NN
cord-015021-pol2qm74	70	56	,	,	,
cord-015021-pol2qm74	70	57	we	-PRON-	PRP
cord-015021-pol2qm74	70	58	were	be	VBD
cord-015021-pol2qm74	70	59	also	also	RB
cord-015021-pol2qm74	70	60	able	able	JJ
cord-015021-pol2qm74	70	61	to	to	TO
cord-015021-pol2qm74	70	62	demonstrate	demonstrate	VB
cord-015021-pol2qm74	70	63	activation	activation	NN
cord-015021-pol2qm74	70	64	of	of	IN
cord-015021-pol2qm74	70	65	the	the	DT
cord-015021-pol2qm74	70	66	contact	contact	NN
cord-015021-pol2qm74	70	67	system	system	NN
cord-015021-pol2qm74	70	68	with	with	IN
cord-015021-pol2qm74	70	69	a	a	DT
cord-015021-pol2qm74	70	70	rise	rise	NN
cord-015021-pol2qm74	70	71	of	of	IN
cord-015021-pol2qm74	70	72	alpha-2macrogiebulin	alpha-2macrogiebulin	NN
cord-015021-pol2qm74	70	73	-	-	HYPH
cord-015021-pol2qm74	70	74	kalllkrein	kalllkrein	NNP
cord-015021-pol2qm74	70	75	complex	complex	NN
cord-015021-pol2qm74	70	76	.	.	.
cord-015021-pol2qm74	71	1	We	-PRON-	PRP
cord-015021-pol2qm74	71	2	have	have	VBP
cord-015021-pol2qm74	71	3	also	also	RB
cord-015021-pol2qm74	71	4	examined	examine	VBN
cord-015021-pol2qm74	71	5	,	,	,
cord-015021-pol2qm74	71	6	J~	J~	``
cord-015021-pol2qm74	71	7	an	an	DT
cord-015021-pol2qm74	71	8	i	i	NN
cord-015021-pol2qm74	71	9	~	~	NFP
cord-015021-pol2qm74	71	10	tensive	tensive	NNP
cord-015021-pol2qm74	71	11	care	care	NN
cord-015021-pol2qm74	71	12	situation	situation	NN
cord-015021-pol2qm74	71	13	,	,	,
cord-015021-pol2qm74	71	14	patients	patient	NNS
cord-015021-pol2qm74	71	15	with	with	IN
cord-015021-pol2qm74	71	16	SIRS	SIRS	NNP
cord-015021-pol2qm74	71	17	.	.	.
cord-015021-pol2qm74	72	1	We	-PRON-	PRP
cord-015021-pol2qm74	72	2	found	find	VBD
cord-015021-pol2qm74	72	3	that	that	IN
cord-015021-pol2qm74	72	4	serial	serial	JJ
cord-015021-pol2qm74	72	5	measuremezzts	measuremezzt	NNS
cord-015021-pol2qm74	72	6	of	of	IN
cord-015021-pol2qm74	72	7	the	the	DT
cord-015021-pol2qm74	72	8	contact	contact	NN
cord-015021-pol2qm74	72	9	system	system	NN
cord-015021-pol2qm74	72	10	were	be	VBD
cord-015021-pol2qm74	72	11	useful	useful	JJ
cord-015021-pol2qm74	72	12	in	in	IN
cord-015021-pol2qm74	72	13	eva	eva	NNP
cord-015021-pol2qm74	73	1	~u	~u	NNP
cord-015021-pol2qm74	73	2	~	~	NFP
cord-015021-pol2qm74	73	3	ting	ting	NNP
cord-015021-pol2qm74	73	4	prognosis+	prognosis+	NNP
cord-015021-pol2qm74	73	5	These	these	DT
cord-015021-pol2qm74	73	6	studies	study	NNS
cord-015021-pol2qm74	73	7	suggest	suggest	VBP
cord-015021-pol2qm74	73	8	that	that	IN
cord-015021-pol2qm74	73	9	inhibition	inhibition	NN
cord-015021-pol2qm74	73	10	of	of	IN
cord-015021-pol2qm74	73	11	kalllkrein	kalllkrein	NNP
cord-015021-pol2qm74	73	12	a	a	DT
cord-015021-pol2qm74	73	13	~	~	NFP
cord-015021-pol2qm74	73	14	d	d	NN
cord-015021-pol2qm74	73	15	l	l	NN
cord-015021-pol2qm74	73	16	e	e	NN
cord-015021-pol2qm74	73	17	r	r	NN
cord-015021-pol2qm74	73	18	bradykinin	bradykinin	NN
cord-015021-pol2qm74	73	19	actions	action	NNS
cord-015021-pol2qm74	73	20	might	may	MD
cord-015021-pol2qm74	73	21	be	be	VB
cord-015021-pol2qm74	73	22	useful	useful	JJ
cord-015021-pol2qm74	73	23	i~	i~	CD
cord-015021-pol2qm74	73	24	obviating	obviate	VBG
cord-015021-pol2qm74	73	25	many	many	JJ
cord-015021-pol2qm74	73	26	.of	.of	.
cord-015021-pol2qm74	74	1	the	the	DT
cord-015021-pol2qm74	74	2	features	feature	NNS
cord-015021-pol2qm74	74	3	seen	see	VBN
cord-015021-pol2qm74	74	4	in	in	IN
cord-015021-pol2qm74	74	5	sepsis	sepsis	NN
cord-015021-pol2qm74	74	6	and	and	CC
cord-015021-pol2qm74	74	7	septic	septic	JJ
cord-015021-pol2qm74	74	8	shock	shock	NN
cord-015021-pol2qm74	74	9	.	.	.
cord-015021-pol2qm74	75	1	Dextran	dextran	NN
cord-015021-pol2qm74	75	2	sulfate	sulfate	NN
cord-015021-pol2qm74	75	3	(	(	-LRB-
cord-015021-pol2qm74	75	4	DXS	DXS	NNP
cord-015021-pol2qm74	75	5	)	)	-RRB-
cord-015021-pol2qm74	75	6	activates	activate	VBZ
cord-015021-pol2qm74	75	7	the	the	DT
cord-015021-pol2qm74	75	8	contact	contact	NN
cord-015021-pol2qm74	75	9	system	system	NN
cord-015021-pol2qm74	75	10	and	and	CC
cord-015021-pol2qm74	75	11	,	,	,
cord-015021-pol2qm74	75	12	in	in	IN
cord-015021-pol2qm74	75	13	vivo	vivo	NN
cord-015021-pol2qm74	75	14	,	,	,
cord-015021-pol2qm74	75	15	produces	produce	VBZ
cord-015021-pol2qm74	75	16	transient	transient	JJ
cord-015021-pol2qm74	75	17	hypotension	hypotension	NN
cord-015021-pol2qm74	75	18	.	.	.
cord-015021-pol2qm74	76	1	In	in	IN
cord-015021-pol2qm74	76	2	order	order	NN
cord-015021-pol2qm74	76	3	to	to	TO
cord-015021-pol2qm74	76	4	better	better	RB
cord-015021-pol2qm74	76	5	define	define	VB
cord-015021-pol2qm74	76	6	the	the	DT
cord-015021-pol2qm74	76	7	mechanisms	mechanism	NNS
cord-015021-pol2qm74	76	8	underlying	underlie	VBG
cord-015021-pol2qm74	76	9	the	the	DT
cord-015021-pol2qm74	76	10	DXS	DXS	NNP
cord-015021-pol2qm74	76	11	-	-	HYPH
cord-015021-pol2qm74	76	12	induced	induce	VBN
cord-015021-pol2qm74	76	13	hypotension	hypotension	NN
cord-015021-pol2qm74	76	14	,	,	,
cord-015021-pol2qm74	76	15	we	-PRON-	PRP
cord-015021-pol2qm74	76	16	investigated	investigate	VBD
cord-015021-pol2qm74	76	17	the	the	DT
cord-015021-pol2qm74	76	18	effects	effect	NNS
cord-015021-pol2qm74	76	19	of	of	IN
cord-015021-pol2qm74	76	20	either	either	CC
cord-015021-pol2qm74	76	21	the	the	DT
cord-015021-pol2qm74	76	22	plasma	plasma	NN
cord-015021-pol2qm74	76	23	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	76	24	inhibitor	inhibitor	NNP
cord-015021-pol2qm74	76	25	,	,	,
cord-015021-pol2qm74	76	26	des	des	NNP
cord-015021-pol2qm74	76	27	-	-	HYPH
cord-015021-pol2qm74	76	28	Pro2-iArg]5]aprotinin	Pro2-iArg]5]aprotinin	NNP
cord-015021-pol2qm74	76	29	(	(	-LRB-
cord-015021-pol2qm74	76	30	BAY	BAY	NNP
cord-015021-pol2qm74	76	31	4620	4620	CD
cord-015021-pol2qm74	76	32	)	)	-RRB-
cord-015021-pol2qm74	76	33	or	or	CC
cord-015021-pol2qm74	76	34	the	the	DT
cord-015021-pol2qm74	76	35	B2	B2	NNP
cord-015021-pol2qm74	76	36	kinin	kinin	NNP
cord-015021-pol2qm74	76	37	antagonist	antagonist	NN
cord-015021-pol2qm74	76	38	,	,	,
cord-015021-pol2qm74	76	39	Hoe	hoe	VB
cord-015021-pol2qm74	76	40	140	140	CD
cord-015021-pol2qm74	76	41	on	on	IN
cord-015021-pol2qm74	76	42	the	the	DT
cord-015021-pol2qm74	76	43	hypotensive	hypotensive	JJ
cord-015021-pol2qm74	76	44	response	response	NN
cord-015021-pol2qm74	76	45	to	to	IN
cord-015021-pol2qm74	76	46	DXS	DXS	NNP
cord-015021-pol2qm74	76	47	.	.	.
cord-015021-pol2qm74	77	1	In	in	IN
cord-015021-pol2qm74	77	2	the	the	DT
cord-015021-pol2qm74	77	3	first	first	JJ
cord-015021-pol2qm74	77	4	study	study	NN
cord-015021-pol2qm74	77	5	,	,	,
cord-015021-pol2qm74	77	6	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	77	7	miniature	miniature	JJ
cord-015021-pol2qm74	77	8	pigs	pig	NNS
cord-015021-pol2qm74	77	9	(	(	-LRB-
cord-015021-pol2qm74	77	10	5	5	CD
cord-015021-pol2qm74	77	11	pigs	pig	NNS
cord-015021-pol2qm74	77	12	/	/	SYM
cord-015021-pol2qm74	77	13	group	group	NN
cord-015021-pol2qm74	77	14	,	,	,
cord-015021-pol2qm74	77	15	randomly	randomly	RB
cord-015021-pol2qm74	77	16	assigned	assign	VBD
cord-015021-pol2qm74	77	17	)	)	-RRB-
cord-015021-pol2qm74	77	18	were	be	VBD
cord-015021-pol2qm74	77	19	given	give	VBN
cord-015021-pol2qm74	77	20	one	one	CD
cord-015021-pol2qm74	77	21	of	of	IN
cord-015021-pol2qm74	77	22	the	the	DT
cord-015021-pol2qm74	77	23	following	following	JJ
cord-015021-pol2qm74	77	24	treatment	treatment	NN
cord-015021-pol2qm74	77	25	protocols	protocol	NNS
cord-015021-pol2qm74	77	26	:	:	:
cord-015021-pol2qm74	77	27	1	1	LS
cord-015021-pol2qm74	77	28	)	)	-RRB-
cord-015021-pol2qm74	77	29	DXS	DXS	NNP
cord-015021-pol2qm74	77	30	(	(	-LRB-
cord-015021-pol2qm74	77	31	5	5	CD
cord-015021-pol2qm74	77	32	mg	mg	NNP
cord-015021-pol2qm74	77	33	/	/	SYM
cord-015021-pol2qm74	77	34	kg	kg	NNP
cord-015021-pol2qm74	77	35	)	)	-RRB-
cord-015021-pol2qm74	77	36	,	,	,
cord-015021-pol2qm74	77	37	2	2	CD
cord-015021-pol2qm74	77	38	-	-	SYM
cord-015021-pol2qm74	77	39	5	5	CD
cord-015021-pol2qm74	77	40	)	)	-RRB-
cord-015021-pol2qm74	77	41	DXS	DXS	NNP
cord-015021-pol2qm74	77	42	plus	plus	CC
cord-015021-pol2qm74	77	43	BAY	BAY	NNP
cord-015021-pol2qm74	77	44	4620	4620	CD
cord-015021-pol2qm74	77	45	(	(	-LRB-
cord-015021-pol2qm74	77	46	45	45	CD
cord-015021-pol2qm74	77	47	,	,	,
cord-015021-pol2qm74	77	48	90	90	CD
cord-015021-pol2qm74	77	49	,	,	,
cord-015021-pol2qm74	77	50	180	180	CD
cord-015021-pol2qm74	77	51	,	,	,
cord-015021-pol2qm74	77	52	or	or	CC
cord-015021-pol2qm74	77	53	360	360	CD
cord-015021-pol2qm74	77	54	rag	rag	NN
cord-015021-pol2qm74	77	55	)	)	-RRB-
cord-015021-pol2qm74	77	56	,	,	,
cord-015021-pol2qm74	77	57	or	or	CC
cord-015021-pol2qm74	77	58	6	6	CD
cord-015021-pol2qm74	77	59	)	)	-RRB-
cord-015021-pol2qm74	77	60	saline	saline	NN
cord-015021-pol2qm74	77	61	.	.	.
cord-015021-pol2qm74	78	1	DXS	DXS	NNP
cord-015021-pol2qm74	78	2	alone	alone	RB
cord-015021-pol2qm74	78	3	produced	produce	VBD
cord-015021-pol2qm74	78	4	a	a	DT
cord-015021-pol2qm74	78	5	profound	profound	JJ
cord-015021-pol2qm74	78	6	but	but	CC
cord-015021-pol2qm74	78	7	transient	transient	JJ
cord-015021-pol2qm74	78	8	systemic	systemic	JJ
cord-015021-pol2qm74	78	9	arterial	arterial	JJ
cord-015021-pol2qm74	78	10	hypotension	hypotension	NN
cord-015021-pol2qm74	78	11	with	with	IN
cord-015021-pol2qm74	78	12	a	a	DT
cord-015021-pol2qm74	78	13	corresponding	corresponding	JJ
cord-015021-pol2qm74	78	14	reduction	reduction	NN
cord-015021-pol2qm74	78	15	in	in	IN
cord-015021-pol2qm74	78	16	plasma	plasma	NN
cord-015021-pol2qm74	78	17	kinin	kinin	NN
cord-015021-pol2qm74	78	18	-	-	HYPH
cord-015021-pol2qm74	78	19	containing	contain	VBG
cord-015021-pol2qm74	78	20	kininogen	kininogen	NNP
cord-015021-pol2qm74	78	21	.	.	.
cord-015021-pol2qm74	79	1	Circulating	circulate	VBG
cord-015021-pol2qm74	79	2	kinin	kinin	NN
cord-015021-pol2qm74	79	3	levels	level	NNS
cord-015021-pol2qm74	79	4	,	,	,
cord-015021-pol2qm74	79	5	complement	complement	NN
cord-015021-pol2qm74	79	6	fragment	fragment	NN
cord-015021-pol2qm74	79	7	C3adesArg	c3adesarg	NN
cord-015021-pol2qm74	79	8	and	and	CC
cord-015021-pol2qm74	79	9	fibrin	fibrin	NN
cord-015021-pol2qm74	79	10	mom)mer	mom)mer	NNP
cord-015021-pol2qm74	79	11	were	be	VBD
cord-015021-pol2qm74	79	12	all	all	RB
cord-015021-pol2qm74	79	13	increased	increase	VBN
cord-015021-pol2qm74	79	14	.	.	.
cord-015021-pol2qm74	80	1	BAY	BAY	NNP
cord-015021-pol2qm74	80	2	4620	4620	CD
cord-015021-pol2qm74	80	3	produced	produce	VBD
cord-015021-pol2qm74	80	4	a	a	DT
cord-015021-pol2qm74	80	5	dose	dose	NN
cord-015021-pol2qm74	80	6	-	-	HYPH
cord-015021-pol2qm74	80	7	dependent	dependent	JJ
cord-015021-pol2qm74	80	8	delay	delay	NN
cord-015021-pol2qm74	80	9	or	or	CC
cord-015021-pol2qm74	80	10	attenuation	attenuation	NN
cord-015021-pol2qm74	80	11	in	in	IN
cord-015021-pol2qm74	80	12	these	these	DT
cord-015021-pol2qm74	80	13	effects	effect	NNS
cord-015021-pol2qm74	80	14	with	with	IN
cord-015021-pol2qm74	80	15	the	the	DT
cord-015021-pol2qm74	80	16	highest	high	JJS
cord-015021-pol2qm74	80	17	dose	dose	NN
cord-015021-pol2qm74	80	18	completely	completely	RB
cord-015021-pol2qm74	80	19	blocking	block	VBG
cord-015021-pol2qm74	80	20	DXS	DXS	NNP
cord-015021-pol2qm74	80	21	-	-	HYPH
cord-015021-pol2qm74	80	22	induced	induce	VBN
cord-015021-pol2qm74	80	23	hypotension	hypotension	NN
cord-015021-pol2qm74	80	24	and	and	CC
cord-015021-pol2qm74	80	25	elevations	elevation	NNS
cord-015021-pol2qm74	80	26	of	of	IN
cord-015021-pol2qm74	80	27	kinin	kinin	NNP
cord-015021-pol2qm74	80	28	,	,	,
cord-015021-pol2qm74	80	29	C3adesArg	c3adesarg	NN
cord-015021-pol2qm74	80	30	and	and	CC
cord-015021-pol2qm74	80	31	fibrin	fibrin	NN
cord-015021-pol2qm74	80	32	monomer	monomer	NN
cord-015021-pol2qm74	80	33	levels	level	NNS
cord-015021-pol2qm74	80	34	.	.	.
cord-015021-pol2qm74	81	1	Thus	thus	RB
cord-015021-pol2qm74	81	2	,	,	,
cord-015021-pol2qm74	81	3	the	the	DT
cord-015021-pol2qm74	81	4	effects	effect	NNS
cord-015021-pol2qm74	81	5	of	of	IN
cord-015021-pol2qm74	81	6	DXS	DXS	NNP
cord-015021-pol2qm74	81	7	are	be	VBP
cord-015021-pol2qm74	81	8	solely	solely	RB
cord-015021-pol2qm74	81	9	dependent	dependent	JJ
cord-015021-pol2qm74	81	10	on	on	IN
cord-015021-pol2qm74	81	11	contact	contact	NN
cord-015021-pol2qm74	81	12	system	system	NN
cord-015021-pol2qm74	81	13	activation	activation	NN
cord-015021-pol2qm74	81	14	and	and	CC
cord-015021-pol2qm74	81	15	this	this	DT
cord-015021-pol2qm74	81	16	activation	activation	NN
cord-015021-pol2qm74	81	17	is	be	VBZ
cord-015021-pol2qm74	81	18	sensitive	sensitive	JJ
cord-015021-pol2qm74	81	19	to	to	IN
cord-015021-pol2qm74	81	20	BAY	BAY	NNP
cord-015021-pol2qm74	81	21	4620	4620	CD
cord-015021-pol2qm74	81	22	.	.	.
cord-015021-pol2qm74	82	1	llowev~:r	llowev~:r	NNP
cord-015021-pol2qm74	82	2	,	,	,
cord-015021-pol2qm74	82	3	contact	contact	NN
cord-015021-pol2qm74	82	4	system	system	NN
cord-015021-pol2qm74	82	5	activation	activation	NN
cord-015021-pol2qm74	82	6	is	be	VBZ
cord-015021-pol2qm74	82	7	known	know	VBN
cord-015021-pol2qm74	82	8	to	to	TO
cord-015021-pol2qm74	82	9	produce	produce	VB
cord-015021-pol2qm74	82	10	changes	change	NNS
cord-015021-pol2qm74	82	11	in	in	IN
cord-015021-pol2qm74	82	12	a	a	DT
cord-015021-pol2qm74	82	13	variety	variety	NN
cord-015021-pol2qm74	82	14	of	of	IN
cord-015021-pol2qm74	82	15	vasoactive	vasoactive	JJ
cord-015021-pol2qm74	82	16	mediators	mediator	NNS
cord-015021-pol2qm74	82	17	,	,	,
cord-015021-pol2qm74	82	18	all	all	DT
cord-015021-pol2qm74	82	19	of	of	IN
cord-015021-pol2qm74	82	20	which	which	WDT
cord-015021-pol2qm74	82	21	can	can	MD
cord-015021-pol2qm74	82	22	affect	affect	VB
cord-015021-pol2qm74	82	23	blood	blood	NN
cord-015021-pol2qm74	82	24	pressure	pressure	NN
cord-015021-pol2qm74	82	25	.	.	.
cord-015021-pol2qm74	83	1	In	in	IN
cord-015021-pol2qm74	83	2	a	a	DT
cord-015021-pol2qm74	83	3	second	second	JJ
cord-015021-pol2qm74	83	4	study	study	NN
cord-015021-pol2qm74	83	5	,	,	,
cord-015021-pol2qm74	83	6	two	two	CD
cord-015021-pol2qm74	83	7	groups	group	NNS
cord-015021-pol2qm74	83	8	of	of	IN
cord-015021-pol2qm74	83	9	pigs	pig	NNS
cord-015021-pol2qm74	83	10	(	(	-LRB-
cord-015021-pol2qm74	83	11	3	3	CD
cord-015021-pol2qm74	83	12	/	/	SYM
cord-015021-pol2qm74	83	13	group	group	NN
cord-015021-pol2qm74	83	14	)	)	-RRB-
cord-015021-pol2qm74	83	15	were	be	VBD
cord-015021-pol2qm74	83	16	given	give	VBN
cord-015021-pol2qm74	83	17	either	either	CC
cord-015021-pol2qm74	83	18	DXS	DXS	NNP
cord-015021-pol2qm74	83	19	alone	alone	JJ
cord-015021-pol2qm74	83	20	(	(	-LRB-
cord-015021-pol2qm74	83	21	2	2	CD
cord-015021-pol2qm74	83	22	mg	mg	NNP
cord-015021-pol2qm74	83	23	/	/	SYM
cord-015021-pol2qm74	83	24	kg	kg	NNP
cord-015021-pol2qm74	83	25	)	)	-RRB-
cord-015021-pol2qm74	83	26	or	or	CC
cord-015021-pol2qm74	83	27	DXS	DXS	NNP
cord-015021-pol2qm74	83	28	10	10	CD
cord-015021-pol2qm74	83	29	minutes	minute	NNS
cord-015021-pol2qm74	83	30	after	after	IN
cord-015021-pol2qm74	83	31	a	a	DT
cord-015021-pol2qm74	83	32	bolus	bolus	NN
cord-015021-pol2qm74	83	33	injection	injection	NN
cord-015021-pol2qm74	83	34	of	of	IN
cord-015021-pol2qm74	83	35	Hoe	Hoe	NNP
cord-015021-pol2qm74	83	36	140	140	CD
cord-015021-pol2qm74	83	37	(	(	-LRB-
cord-015021-pol2qm74	83	38	30	30	CD
cord-015021-pol2qm74	83	39	#	#	NN
cord-015021-pol2qm74	83	40	g	g	NN
cord-015021-pol2qm74	83	41	/	/	SYM
cord-015021-pol2qm74	83	42	kg	kg	NNP
cord-015021-pol2qm74	83	43	)	)	-RRB-
cord-015021-pol2qm74	83	44	.	.	.
cord-015021-pol2qm74	84	1	DXS	DXS	NNP
cord-015021-pol2qm74	84	2	alone	alone	RB
cord-015021-pol2qm74	84	3	produced	produce	VBD
cord-015021-pol2qm74	84	4	transient	transient	JJ
cord-015021-pol2qm74	84	5	hypotenmon	hypotenmon	NN
cord-015021-pol2qm74	84	6	.	.	.
cord-015021-pol2qm74	85	1	This	this	DT
cord-015021-pol2qm74	85	2	response	response	NN
cord-015021-pol2qm74	85	3	was	be	VBD
cord-015021-pol2qm74	85	4	completely	completely	RB
cord-015021-pol2qm74	85	5	blocked	block	VBN
cord-015021-pol2qm74	85	6	by	by	IN
cord-015021-pol2qm74	85	7	Hoe	Hoe	NNP
cord-015021-pol2qm74	85	8	140	140	CD
cord-015021-pol2qm74	85	9	pretreatment	pretreatment	NN
cord-015021-pol2qm74	85	10	.	.	.
cord-015021-pol2qm74	86	1	Both	both	DT
cord-015021-pol2qm74	86	2	groups	group	NNS
cord-015021-pol2qm74	86	3	had	have	VBD
cord-015021-pol2qm74	86	4	identical	identical	JJ
cord-015021-pol2qm74	86	5	reductions	reduction	NNS
cord-015021-pol2qm74	86	6	in	in	IN
cord-015021-pol2qm74	86	7	kinin	kinin	NNP
cord-015021-pol2qm74	86	8	-	-	HYPH
cord-015021-pol2qm74	86	9	containing	contain	VBG
cord-015021-pol2qm74	86	10	kininogen	kininogen	NNP
cord-015021-pol2qm74	86	11	.	.	.
cord-015021-pol2qm74	87	1	We	-PRON-	PRP
cord-015021-pol2qm74	87	2	conclude	conclude	VBP
cord-015021-pol2qm74	87	3	that	that	IN
cord-015021-pol2qm74	87	4	DXS	DXS	NNP
cord-015021-pol2qm74	87	5	-	-	HYPH
cord-015021-pol2qm74	87	6	induced	induce	VBN
cord-015021-pol2qm74	87	7	hypotension	hypotension	NN
cord-015021-pol2qm74	87	8	is	be	VBZ
cord-015021-pol2qm74	87	9	produced	produce	VBN
cord-015021-pol2qm74	87	10	by	by	IN
cord-015021-pol2qm74	87	11	activation	activation	NN
cord-015021-pol2qm74	87	12	of	of	IN
cord-015021-pol2qm74	87	13	the	the	DT
cord-015021-pol2qm74	87	14	contact	contact	NN
cord-015021-pol2qm74	87	15	system	system	NN
cord-015021-pol2qm74	87	16	which	which	WDT
cord-015021-pol2qm74	87	17	results	result	VBZ
cord-015021-pol2qm74	87	18	in	in	IN
cord-015021-pol2qm74	87	19	the	the	DT
cord-015021-pol2qm74	87	20	production	production	NN
cord-015021-pol2qm74	87	21	of	of	IN
cord-015021-pol2qm74	87	22	bradykinin	bradykinin	NN
cord-015021-pol2qm74	87	23	.	.	.
cord-015021-pol2qm74	88	1	Liberation	liberation	NN
cord-015021-pol2qm74	88	2	of	of	IN
cord-015021-pol2qm74	88	3	bradykinin	bradykinin	NN
cord-015021-pol2qm74	88	4	is	be	VBZ
cord-015021-pol2qm74	88	5	both	both	DT
cord-015021-pol2qm74	88	6	necessary	necessary	JJ
cord-015021-pol2qm74	88	7	and	and	CC
cord-015021-pol2qm74	88	8	sufficient	sufficient	JJ
cord-015021-pol2qm74	88	9	to	to	TO
cord-015021-pol2qm74	88	10	produce	produce	VB
cord-015021-pol2qm74	88	11	all	all	DT
cord-015021-pol2qm74	88	12	of	of	IN
cord-015021-pol2qm74	88	13	the	the	DT
cord-015021-pol2qm74	88	14	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	88	15	changes	change	NNS
cord-015021-pol2qm74	88	16	observed	observe	VBD
cord-015021-pol2qm74	88	17	.	.	.
cord-015021-pol2qm74	89	1	Dr.	Dr.	NNP
cord-015021-pol2qm74	89	2	Matthias	Matthias	NNP
cord-015021-pol2qm74	89	3	Siebeck	Siebeck	NNP
cord-015021-pol2qm74	89	4	,	,	,
cord-015021-pol2qm74	89	5	Department	Department	NNP
cord-015021-pol2qm74	89	6	of	of	IN
cord-015021-pol2qm74	89	7	Surgery	Surgery	NNP
cord-015021-pol2qm74	89	8	,	,	,
cord-015021-pol2qm74	89	9	University	University	NNP
cord-015021-pol2qm74	89	10	of	of	IN
cord-015021-pol2qm74	89	11	Munich	Munich	NNP
cord-015021-pol2qm74	89	12	,	,	,
cord-015021-pol2qm74	89	13	Klinikum	Klinikum	NNP
cord-015021-pol2qm74	89	14	lnnenstadt	lnnenstadt	NN
cord-015021-pol2qm74	89	15	,	,	,
cord-015021-pol2qm74	89	16	Nussbaumstrasse	Nussbaumstrasse	NNP
cord-015021-pol2qm74	89	17	20	20	CD
cord-015021-pol2qm74	89	18	,	,	,
cord-015021-pol2qm74	89	19	D-80336	d-80336	CD
cord-015021-pol2qm74	89	20	Munich	Munich	NNP
cord-015021-pol2qm74	89	21	,	,	,
cord-015021-pol2qm74	89	22	Germany	Germany	NNP
cord-015021-pol2qm74	90	1	In	in	IN
cord-015021-pol2qm74	90	2	experimental	experimental	JJ
cord-015021-pol2qm74	90	3	animals	animal	NNS
cord-015021-pol2qm74	90	4	exposed	expose	VBN
cord-015021-pol2qm74	90	5	to	to	IN
cord-015021-pol2qm74	90	6	i.v	i.v	NNP
cord-015021-pol2qm74	90	7	.	.	NNP
cord-015021-pol2qm74	90	8	injection	injection	NN
cord-015021-pol2qm74	90	9	of	of	IN
cord-015021-pol2qm74	90	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	90	11	accumulation	accumulation	NN
cord-015021-pol2qm74	90	12	of	of	IN
cord-015021-pol2qm74	90	13	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	90	14	in	in	IN
cord-015021-pol2qm74	90	15	various	various	JJ
cord-015021-pol2qm74	90	16	organs	organ	NNS
cord-015021-pol2qm74	90	17	as	as	IN
cord-015021-pol2qm74	90	18	lungs	lung	NNS
cord-015021-pol2qm74	90	19	and	and	CC
cord-015021-pol2qm74	90	20	the	the	DT
cord-015021-pol2qm74	90	21	liver	liver	NN
cord-015021-pol2qm74	90	22	is	be	VBZ
cord-015021-pol2qm74	90	23	a	a	DT
cord-015021-pol2qm74	90	24	prominent	prominent	JJ
cord-015021-pol2qm74	90	25	feature	feature	NN
cord-015021-pol2qm74	90	26	.	.	.
cord-015021-pol2qm74	91	1	As	as	IN
cord-015021-pol2qm74	91	2	a	a	DT
cord-015021-pol2qm74	91	3	part	part	NN
cord-015021-pol2qm74	91	4	of	of	IN
cord-015021-pol2qm74	91	5	these	these	DT
cord-015021-pol2qm74	91	6	morphological	morphological	JJ
cord-015021-pol2qm74	91	7	changes	change	NNS
cord-015021-pol2qm74	91	8	damages	damage	NNS
cord-015021-pol2qm74	91	9	of	of	IN
cord-015021-pol2qm74	91	10	endothelial	endothelial	JJ
cord-015021-pol2qm74	91	11	ceils	ceil	NNS
cord-015021-pol2qm74	91	12	are	be	VBP
cord-015021-pol2qm74	91	13	regularly	regularly	RB
cord-015021-pol2qm74	91	14	seen	see	VBN
cord-015021-pol2qm74	91	15	.	.	.
cord-015021-pol2qm74	92	1	This	this	DT
cord-015021-pol2qm74	92	2	process	process	NN
cord-015021-pol2qm74	92	3	,	,	,
cord-015021-pol2qm74	92	4	which	which	WDT
cord-015021-pol2qm74	92	5	is	be	VBZ
cord-015021-pol2qm74	92	6	a	a	DT
cord-015021-pol2qm74	92	7	part	part	NN
cord-015021-pol2qm74	92	8	of	of	IN
cord-015021-pol2qm74	92	9	endothelial	endothelial	JJ
cord-015021-pol2qm74	92	10	-	-	HYPH
cord-015021-pol2qm74	92	11	cellular	cellular	JJ
cord-015021-pol2qm74	92	12	interaction	interaction	NN
cord-015021-pol2qm74	92	13	,	,	,
cord-015021-pol2qm74	92	14	leeds	leeds	NNP
cord-015021-pol2qm74	92	15	to	to	IN
cord-015021-pol2qm74	92	16	exposure	exposure	NN
cord-015021-pol2qm74	92	17	of	of	IN
cord-015021-pol2qm74	92	18	the	the	DT
cord-015021-pol2qm74	92	19	sub	sub	JJ
cord-015021-pol2qm74	92	20	-	-	JJ
cord-015021-pol2qm74	92	21	endothelial	endothelial	JJ
cord-015021-pol2qm74	92	22	basement	basement	NN
cord-015021-pol2qm74	92	23	membran	membran	NN
cord-015021-pol2qm74	92	24	.	.	.
cord-015021-pol2qm74	93	1	The	the	DT
cord-015021-pol2qm74	93	2	basement	basement	NN
cord-015021-pol2qm74	93	3	membran	membran	NN
cord-015021-pol2qm74	93	4	is	be	VBZ
cord-015021-pol2qm74	93	5	known	know	VBN
cord-015021-pol2qm74	93	6	f6r	f6r	PRP
cord-015021-pol2qm74	93	7	its	-PRON-	PRP$
cord-015021-pol2qm74	93	8	capacity	capacity	NN
cord-015021-pol2qm74	93	9	to	to	TO
cord-015021-pol2qm74	93	10	activate	activate	VB
cord-015021-pol2qm74	93	11	the	the	DT
cord-015021-pol2qm74	93	12	contact	contact	NN
cord-015021-pol2qm74	93	13	system	system	NN
cord-015021-pol2qm74	93	14	of	of	IN
cord-015021-pol2qm74	93	15	plasma	plasma	NN
cord-015021-pol2qm74	93	16	.	.	.
cord-015021-pol2qm74	94	1	During	during	IN
cord-015021-pol2qm74	94	2	this	this	DT
cord-015021-pol2qm74	94	3	cascade	cascade	NN
cord-015021-pol2qm74	94	4	activation	activation	NN
cord-015021-pol2qm74	94	5	,	,	,
cord-015021-pol2qm74	94	6	coagulation	coagulation	NN
cord-015021-pol2qm74	94	7	factor	factor	NN
cord-015021-pol2qm74	94	8	XII	XII	NNP
cord-015021-pol2qm74	94	9	is	be	VBZ
cord-015021-pol2qm74	94	10	converted	convert	VBN
cord-015021-pol2qm74	94	11	to	to	IN
cord-015021-pol2qm74	94	12	the	the	DT
cord-015021-pol2qm74	94	13	active	active	JJ
cord-015021-pol2qm74	94	14	factor	factor	NN
cord-015021-pol2qm74	94	15	XII	XII	NNP
cord-015021-pol2qm74	94	16	.	.	.
cord-015021-pol2qm74	95	1	This	this	DT
cord-015021-pol2qm74	95	2	activation	activation	NN
cord-015021-pol2qm74	95	3	might	may	MD
cord-015021-pol2qm74	95	4	produce	produce	VB
cord-015021-pol2qm74	95	5	increased	increase	VBN
cord-015021-pol2qm74	95	6	plasma	plasma	NN
cord-015021-pol2qm74	95	7	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	95	8	activities	activity	NNS
cord-015021-pol2qm74	95	9	and	and	CC
cord-015021-pol2qm74	95	10	thereby	thereby	RB
cord-015021-pol2qm74	95	11	give	give	VB
cord-015021-pol2qm74	95	12	release	release	NN
cord-015021-pol2qm74	95	13	of	of	IN
cord-015021-pol2qm74	95	14	the	the	DT
cord-015021-pol2qm74	95	15	vasoactive	vasoactive	JJ
cord-015021-pol2qm74	95	16	substance	substance	NN
cord-015021-pol2qm74	95	17	bradykinin	bradykinin	NN
cord-015021-pol2qm74	95	18	.	.	.
cord-015021-pol2qm74	96	1	Using	use	VBG
cord-015021-pol2qm74	96	2	a	a	DT
cord-015021-pol2qm74	96	3	porcine	porcine	JJ
cord-015021-pol2qm74	96	4	model	model	NN
cord-015021-pol2qm74	96	5	we	-PRON-	PRP
cord-015021-pol2qm74	96	6	have	have	VBP
cord-015021-pol2qm74	96	7	noticed	notice	VBN
cord-015021-pol2qm74	96	8	that	that	IN
cord-015021-pol2qm74	96	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	96	10	infusion	infusion	NN
cord-015021-pol2qm74	96	11	(	(	-LRB-
cord-015021-pol2qm74	96	12	0,01	0,01	VBZ
cord-015021-pol2qm74	96	13	mg	mg	NNP
cord-015021-pol2qm74	96	14	/	/	SYM
cord-015021-pol2qm74	96	15	kg	kg	NNP
cord-015021-pol2qm74	96	16	)	)	-RRB-
cord-015021-pol2qm74	96	17	induces	induce	VBZ
cord-015021-pol2qm74	96	18	elevated	elevated	JJ
cord-015021-pol2qm74	96	19	plasma	plasma	NN
cord-015021-pol2qm74	96	20	kailikrein	kailikrein	NN
cord-015021-pol2qm74	96	21	activities	activity	NNS
cord-015021-pol2qm74	96	22	within	within	IN
cord-015021-pol2qm74	96	23	two	two	CD
cord-015021-pol2qm74	96	24	hours	hour	NNS
cord-015021-pol2qm74	96	25	after	after	IN
cord-015021-pol2qm74	96	26	the	the	DT
cord-015021-pol2qm74	96	27	start	start	NN
cord-015021-pol2qm74	96	28	of	of	IN
cord-015021-pol2qm74	96	29	the	the	DT
cord-015021-pol2qm74	96	30	infusion	infusion	NN
cord-015021-pol2qm74	96	31	.	.	.
cord-015021-pol2qm74	97	1	This	this	DT
cord-015021-pol2qm74	97	2	enzyme	enzyme	NN
cord-015021-pol2qm74	97	3	activity	activity	NN
cord-015021-pol2qm74	97	4	remained	remain	VBD
cord-015021-pol2qm74	97	5	increased	increase	VBN
cord-015021-pol2qm74	97	6	during	during	IN
cord-015021-pol2qm74	97	7	the	the	DT
cord-015021-pol2qm74	97	8	next	next	JJ
cord-015021-pol2qm74	97	9	hours	hour	NNS
cord-015021-pol2qm74	97	10	and	and	CC
cord-015021-pol2qm74	97	11	reached	reach	VBN
cord-015021-pol2qm74	97	12	value	value	NN
cord-015021-pol2qm74	97	13	of	of	IN
cord-015021-pol2qm74	97	14	up	up	IN
cord-015021-pol2qm74	97	15	to	to	TO
cord-015021-pol2qm74	97	16	50	50	CD
cord-015021-pol2qm74	97	17	U/1	u/1	NN
cord-015021-pol2qm74	97	18	.	.	.
cord-015021-pol2qm74	98	1	In	in	IN
cord-015021-pol2qm74	98	2	patients	patient	NNS
cord-015021-pol2qm74	98	3	with	with	IN
cord-015021-pol2qm74	98	4	sepsis	sepsis	NN
cord-015021-pol2qm74	98	5	we	-PRON-	PRP
cord-015021-pol2qm74	98	6	also	also	RB
cord-015021-pol2qm74	98	7	have	have	VBP
cord-015021-pol2qm74	98	8	observed	observe	VBN
cord-015021-pol2qm74	98	9	elevated	elevated	JJ
cord-015021-pol2qm74	98	10	plasma	plasma	NN
cord-015021-pol2qm74	98	11	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	98	12	activities	activity	NNS
cord-015021-pol2qm74	98	13	with	with	IN
cord-015021-pol2qm74	98	14	enzyme	enzyme	NN
cord-015021-pol2qm74	98	15	activities	activity	NNS
cord-015021-pol2qm74	98	16	up	up	IN
cord-015021-pol2qm74	98	17	to	to	IN
cord-015021-pol2qm74	98	18	200	200	CD
cord-015021-pol2qm74	98	19	U/1	u/1	NN
cord-015021-pol2qm74	98	20	.	.	.
cord-015021-pol2qm74	99	1	In	in	IN
cord-015021-pol2qm74	99	2	order	order	NN
cord-015021-pol2qm74	99	3	to	to	TO
cord-015021-pol2qm74	99	4	further	further	RB
cord-015021-pol2qm74	99	5	elucidate	elucidate	VB
cord-015021-pol2qm74	99	6	the	the	DT
cord-015021-pol2qm74	99	7	significance	significance	NN
cord-015021-pol2qm74	99	8	of	of	IN
cord-015021-pol2qm74	99	9	these	these	DT
cord-015021-pol2qm74	99	10	elevated	elevated	JJ
cord-015021-pol2qm74	99	11	enzyme	enzyme	NN
cord-015021-pol2qm74	99	12	activities	activity	NNS
cord-015021-pol2qm74	99	13	,	,	,
cord-015021-pol2qm74	99	14	we	-PRON-	PRP
cord-015021-pol2qm74	99	15	prepared	prepare	VBD
cord-015021-pol2qm74	99	16	human	human	JJ
cord-015021-pol2qm74	99	17	plasma	plasma	NN
cord-015021-pol2qm74	99	18	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	99	19	and	and	CC
cord-015021-pol2qm74	99	20	injected	inject	VBD
cord-015021-pol2qm74	99	21	it	-PRON-	PRP
cord-015021-pol2qm74	99	22	intravenously	intravenously	RB
cord-015021-pol2qm74	99	23	in	in	IN
cord-015021-pol2qm74	99	24	anaesthetized	anaesthetize	VBN
cord-015021-pol2qm74	99	25	pigs	pig	NNS
cord-015021-pol2qm74	99	26	(	(	-LRB-
cord-015021-pol2qm74	99	27	1	1	CD
cord-015021-pol2qm74	99	28	)	)	-RRB-
cord-015021-pol2qm74	99	29	.	.	.
cord-015021-pol2qm74	100	1	When	when	WRB
cord-015021-pol2qm74	100	2	very	very	RB
cord-015021-pol2qm74	100	3	small	small	JJ
cord-015021-pol2qm74	100	4	plasma	plasma	NN
cord-015021-pol2qm74	100	5	kailikrein	kailikrein	NN
cord-015021-pol2qm74	100	6	activities	activity	NNS
cord-015021-pol2qm74	100	7	(	(	-LRB-
cord-015021-pol2qm74	100	8	0,3	0,3	CD
cord-015021-pol2qm74	100	9	U	U	NNP
cord-015021-pol2qm74	100	10	/	/	SYM
cord-015021-pol2qm74	100	11	kg	kg	NN
cord-015021-pol2qm74	100	12	bodyweight	bodyweight	NN
cord-015021-pol2qm74	100	13	)	)	-RRB-
cord-015021-pol2qm74	100	14	were	be	VBD
cord-015021-pol2qm74	100	15	given	give	VBN
cord-015021-pol2qm74	100	16	intravenously	intravenously	RB
cord-015021-pol2qm74	100	17	a	a	DT
cord-015021-pol2qm74	100	18	50	50	CD
cord-015021-pol2qm74	100	19	%	%	NN
cord-015021-pol2qm74	100	20	decrease	decrease	NN
cord-015021-pol2qm74	100	21	in	in	IN
cord-015021-pol2qm74	100	22	arterial	arterial	JJ
cord-015021-pol2qm74	100	23	blood	blood	NN
cord-015021-pol2qm74	100	24	pressure	pressure	NN
cord-015021-pol2qm74	100	25	was	be	VBD
cord-015021-pol2qm74	100	26	seen	see	VBN
cord-015021-pol2qm74	100	27	in	in	IN
cord-015021-pol2qm74	100	28	the	the	DT
cord-015021-pol2qm74	100	29	animals	animal	NNS
cord-015021-pol2qm74	100	30	.	.	.
cord-015021-pol2qm74	101	1	In	in	IN
cord-015021-pol2qm74	101	2	the	the	DT
cord-015021-pol2qm74	101	3	patients	patient	NNS
cord-015021-pol2qm74	101	4	with	with	IN
cord-015021-pol2qm74	101	5	sepsis	sepsis	NN
cord-015021-pol2qm74	101	6	also	also	RB
cord-015021-pol2qm74	101	7	decreases	decrease	VBZ
cord-015021-pol2qm74	101	8	in	in	IN
cord-015021-pol2qm74	101	9	prekallikrein	prekallikrein	NN
cord-015021-pol2qm74	101	10	values	value	NNS
cord-015021-pol2qm74	101	11	and	and	CC
cord-015021-pol2qm74	101	12	functional	functional	JJ
cord-015021-pol2qm74	101	13	plasma	plasma	NN
cord-015021-pol2qm74	101	14	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	101	15	inhibition	inhibition	NN
cord-015021-pol2qm74	101	16	are	be	VBP
cord-015021-pol2qm74	101	17	frequently	frequently	RB
cord-015021-pol2qm74	101	18	seen	see	VBN
cord-015021-pol2qm74	101	19	.	.	.
cord-015021-pol2qm74	102	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	102	2	,	,	,
cord-015021-pol2qm74	102	3	degradation	degradation	NN
cord-015021-pol2qm74	102	4	of	of	IN
cord-015021-pol2qm74	102	5	high	high	JJ
cord-015021-pol2qm74	102	6	molecular	molecular	JJ
cord-015021-pol2qm74	102	7	weight	weight	NN
cord-015021-pol2qm74	102	8	kioinogen	kioinogen	NNP
cord-015021-pol2qm74	102	9	is	be	VBZ
cord-015021-pol2qm74	102	10	found	find	VBN
cord-015021-pol2qm74	102	11	in	in	IN
cord-015021-pol2qm74	102	12	these	these	DT
cord-015021-pol2qm74	102	13	patients	patient	NNS
cord-015021-pol2qm74	102	14	indicating	indicate	VBG
cord-015021-pol2qm74	102	15	formation	formation	NN
cord-015021-pol2qm74	102	16	of	of	IN
cord-015021-pol2qm74	102	17	bradykinin	bradykinin	NN
cord-015021-pol2qm74	102	18	.	.	.
cord-015021-pol2qm74	103	1	These	these	DT
cord-015021-pol2qm74	103	2	experimental	experimental	JJ
cord-015021-pol2qm74	103	3	and	and	CC
cord-015021-pol2qm74	103	4	clinical	clinical	JJ
cord-015021-pol2qm74	103	5	studies	study	NNS
cord-015021-pol2qm74	103	6	underline	underline	VBP
cord-015021-pol2qm74	103	7	that	that	IN
cord-015021-pol2qm74	103	8	contact	contact	NN
cord-015021-pol2qm74	103	9	activation	activation	NN
cord-015021-pol2qm74	103	10	in	in	IN
cord-015021-pol2qm74	103	11	sepsis	sepsis	NN
cord-015021-pol2qm74	103	12	might	may	MD
cord-015021-pol2qm74	103	13	results	result	VBZ
cord-015021-pol2qm74	103	14	in	in	IN
cord-015021-pol2qm74	103	15	the	the	DT
cord-015021-pol2qm74	103	16	release	release	NN
cord-015021-pol2qm74	103	17	of	of	IN
cord-015021-pol2qm74	103	18	very	very	RB
cord-015021-pol2qm74	103	19	powerful	powerful	JJ
cord-015021-pol2qm74	103	20	mediator	mediator	NN
cord-015021-pol2qm74	103	21	substances	substance	NNS
cord-015021-pol2qm74	103	22	which	which	WDT
cord-015021-pol2qm74	103	23	can	can	MD
cord-015021-pol2qm74	103	24	be	be	VB
cord-015021-pol2qm74	103	25	of	of	IN
cord-015021-pol2qm74	103	26	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	103	27	importance	importance	NN
cord-015021-pol2qm74	103	28	in	in	IN
cord-015021-pol2qm74	103	29	this	this	DT
cord-015021-pol2qm74	103	30	disease	disease	NN
cord-015021-pol2qm74	103	31	.	.	.
cord-015021-pol2qm74	104	1	A	a	DT
cord-015021-pol2qm74	104	2	number	number	NN
cord-015021-pol2qm74	104	3	of	of	IN
cord-015021-pol2qm74	104	4	pathological	pathological	JJ
cord-015021-pol2qm74	104	5	disorders	disorder	NNS
cord-015021-pol2qm74	104	6	as	as	IN
cord-015021-pol2qm74	104	7	reperfusion	reperfusion	NN
cord-015021-pol2qm74	104	8	injury	injury	NN
cord-015021-pol2qm74	104	9	,	,	,
cord-015021-pol2qm74	104	10	bone	bone	NN
cord-015021-pol2qm74	104	11	marrow	marrow	NN
cord-015021-pol2qm74	104	12	transplantation	transplantation	NN
cord-015021-pol2qm74	104	13	,	,	,
cord-015021-pol2qm74	104	14	polytrauma	polytrauma	NN
cord-015021-pol2qm74	104	15	and	and	CC
cord-015021-pol2qm74	104	16	septic	septic	JJ
cord-015021-pol2qm74	104	17	shock	shock	NN
cord-015021-pol2qm74	104	18	are	be	VBP
cord-015021-pol2qm74	104	19	associated	associate	VBN
cord-015021-pol2qm74	104	20	with	with	IN
cord-015021-pol2qm74	104	21	capillary	capillary	JJ
cord-015021-pol2qm74	104	22	leakage	leakage	NN
cord-015021-pol2qm74	104	23	.	.	.
cord-015021-pol2qm74	105	1	As	as	IN
cord-015021-pol2qm74	105	2	the	the	DT
cord-015021-pol2qm74	105	3	activation	activation	NN
cord-015021-pol2qm74	105	4	of	of	IN
cord-015021-pol2qm74	105	5	the	the	DT
cord-015021-pol2qm74	105	6	complement	complement	JJ
cord-015021-pol2qm74	105	7	system	system	NN
cord-015021-pol2qm74	105	8	and	and	CC
cord-015021-pol2qm74	105	9	the	the	DT
cord-015021-pol2qm74	105	10	contact	contact	NN
cord-015021-pol2qm74	105	11	phase	phase	NN
cord-015021-pol2qm74	105	12	play	play	VBP
cord-015021-pol2qm74	105	13	a	a	DT
cord-015021-pol2qm74	105	14	major	major	JJ
cord-015021-pol2qm74	105	15	role	role	NN
cord-015021-pol2qm74	105	16	in	in	IN
cord-015021-pol2qm74	105	17	these	these	DT
cord-015021-pol2qm74	105	18	diseases	disease	NNS
cord-015021-pol2qm74	105	19	we	-PRON-	PRP
cord-015021-pol2qm74	105	20	investigated	investigate	VBD
cord-015021-pol2qm74	105	21	whether	whether	IN
cord-015021-pol2qm74	105	22	Cl	Cl	NNP
cord-015021-pol2qm74	105	23	-	-	HYPH
cord-015021-pol2qm74	105	24	lnhibitor	lnhibitor	NNP
cord-015021-pol2qm74	105	25	(	(	-LRB-
cord-015021-pol2qm74	105	26	C1-INH	C1-INH	NNP
cord-015021-pol2qm74	105	27	)	)	-RRB-
cord-015021-pol2qm74	105	28	,	,	,
cord-015021-pol2qm74	105	29	which	which	WDT
cord-015021-pol2qm74	105	30	inactivates	inactivate	VBZ
cord-015021-pol2qm74	105	31	Cl	Cl	NNP
cord-015021-pol2qm74	105	32	-	-	HYPH
cord-015021-pol2qm74	105	33	esterase	esterase	NN
cord-015021-pol2qm74	105	34	,	,	,
cord-015021-pol2qm74	105	35	kallikrein	kallikrein	NN
cord-015021-pol2qm74	105	36	and	and	CC
cord-015021-pol2qm74	105	37	clotting	clotting	NN
cord-015021-pol2qm74	105	38	factors	factor	NNS
cord-015021-pol2qm74	105	39	XII	XII	NNP
cord-015021-pol2qm74	105	40	and	and	CC
cord-015021-pol2qm74	105	41	Xl	Xl	NNP
cord-015021-pol2qm74	105	42	,	,	,
cord-015021-pol2qm74	105	43	could	could	MD
cord-015021-pol2qm74	105	44	abolish	abolish	VB
cord-015021-pol2qm74	105	45	vascular	vascular	JJ
cord-015021-pol2qm74	105	46	leakage	leakage	NN
cord-015021-pol2qm74	105	47	.	.	.
cord-015021-pol2qm74	106	1	A	a	DT
cord-015021-pol2qm74	106	2	capillary	capillary	JJ
cord-015021-pol2qm74	106	3	leakage	leakage	NN
cord-015021-pol2qm74	106	4	was	be	VBD
cord-015021-pol2qm74	106	5	induced	induce	VBN
cord-015021-pol2qm74	106	6	in	in	IN
cord-015021-pol2qm74	106	7	rats	rat	NNS
cord-015021-pol2qm74	106	8	by	by	IN
cord-015021-pol2qm74	106	9	the	the	DT
cord-015021-pol2qm74	106	10	administration	administration	NN
cord-015021-pol2qm74	106	11	of	of	IN
cord-015021-pol2qm74	106	12	interleukin-2	interleukin-2	NNP
cord-015021-pol2qm74	106	13	(	(	-LRB-
cord-015021-pol2qm74	106	14	5	5	CD
cord-015021-pol2qm74	106	15	x	x	SYM
cord-015021-pol2qm74	106	16	106	106	CD
cord-015021-pol2qm74	106	17	IU	IU	NNP
cord-015021-pol2qm74	106	18	/	/	SYM
cord-015021-pol2qm74	106	19	kg	kg	NNP
cord-015021-pol2qm74	106	20	)	)	-RRB-
cord-015021-pol2qm74	106	21	.	.	.
cord-015021-pol2qm74	107	1	The	the	DT
cord-015021-pol2qm74	107	2	increased	increased	JJ
cord-015021-pol2qm74	107	3	vascular	vascular	JJ
cord-015021-pol2qm74	107	4	permeability	permeability	NN
cord-015021-pol2qm74	107	5	was	be	VBD
cord-015021-pol2qm74	107	6	monitored	monitor	VBN
cord-015021-pol2qm74	107	7	for	for	IN
cord-015021-pol2qm74	107	8	one	one	CD
cord-015021-pol2qm74	107	9	hour	hour	NN
cord-015021-pol2qm74	107	10	as	as	IN
cord-015021-pol2qm74	107	11	the	the	DT
cord-015021-pol2qm74	107	12	extravasation	extravasation	NN
cord-015021-pol2qm74	107	13	of	of	IN
cord-015021-pol2qm74	107	14	FITC	FITC	NNP
cord-015021-pol2qm74	107	15	marked	mark	VBD
cord-015021-pol2qm74	107	16	rat	rat	NN
cord-015021-pol2qm74	107	17	serum	serum	NN
cord-015021-pol2qm74	107	18	albumin	albumin	NN
cord-015021-pol2qm74	107	19	from	from	IN
cord-015021-pol2qm74	107	20	a	a	DT
cord-015021-pol2qm74	107	21	mesenterial	mesenterial	JJ
cord-015021-pol2qm74	107	22	vessel	vessel	NN
cord-015021-pol2qm74	107	23	by	by	IN
cord-015021-pol2qm74	107	24	a	a	DT
cord-015021-pol2qm74	107	25	video	video	NN
cord-015021-pol2qm74	107	26	-	-	HYPH
cord-015021-pol2qm74	107	27	image	image	NN
cord-015021-pol2qm74	107	28	processing	processing	NN
cord-015021-pol2qm74	107	29	system	system	NN
cord-015021-pol2qm74	107	30	.	.	.
cord-015021-pol2qm74	108	1	CI	CI	NNP
cord-015021-pol2qm74	108	2	-	-	HYPH
cord-015021-pol2qm74	108	3	INH	INH	NNP
cord-015021-pol2qm74	109	1	(	(	-LRB-
cord-015021-pol2qm74	109	2	Berinert	Berinert	NNP
cord-015021-pol2qm74	109	3	®	®	ADD
cord-015021-pol2qm74	109	4	,	,	,
cord-015021-pol2qm74	109	5	Behringwerke	Behringwerke	NNP
cord-015021-pol2qm74	109	6	)	)	-RRB-
cord-015021-pol2qm74	109	7	given	give	VBN
cord-015021-pol2qm74	109	8	as	as	IN
cord-015021-pol2qm74	109	9	a	a	DT
cord-015021-pol2qm74	109	10	single	single	JJ
cord-015021-pol2qm74	109	11	i.v	i.v	NNP
cord-015021-pol2qm74	109	12	.	.	NNP
cord-015021-pol2qm74	109	13	bolus	bolus	NN
cord-015021-pol2qm74	109	14	in	in	IN
cord-015021-pol2qm74	109	15	concentrations	concentration	NNS
cord-015021-pol2qm74	109	16	of	of	IN
cord-015021-pol2qm74	109	17	100	100	CD
cord-015021-pol2qm74	109	18	,	,	,
cord-015021-pol2qm74	109	19	250	250	CD
cord-015021-pol2qm74	109	20	or	or	CC
cord-015021-pol2qm74	109	21	500	500	CD
cord-015021-pol2qm74	109	22	U	u	NN
cord-015021-pol2qm74	109	23	/	/	SYM
cord-015021-pol2qm74	109	24	kg	kg	CC
cord-015021-pol2qm74	109	25	dose	dose	RB
cord-015021-pol2qm74	109	26	-	-	HYPH
cord-015021-pol2qm74	109	27	dependently	dependently	RB
cord-015021-pol2qm74	109	28	prevented	prevent	VBD
cord-015021-pol2qm74	109	29	the	the	DT
cord-015021-pol2qm74	109	30	capillary	capillary	JJ
cord-015021-pol2qm74	109	31	leakage	leakage	NN
cord-015021-pol2qm74	109	32	.	.	.
cord-015021-pol2qm74	110	1	Carrageenaninduced	carrageenaninduced	JJ
cord-015021-pol2qm74	110	2	inflammation	inflammation	NN
cord-015021-pol2qm74	110	3	in	in	IN
cord-015021-pol2qm74	110	4	the	the	DT
cord-015021-pol2qm74	110	5	rat	rat	NN
cord-015021-pol2qm74	110	6	leads	lead	VBZ
cord-015021-pol2qm74	110	7	to	to	IN
cord-015021-pol2qm74	110	8	vascutar	vascutar	NN
cord-015021-pol2qm74	110	9	leakage	leakage	NN
cord-015021-pol2qm74	110	10	and	and	CC
cord-015021-pol2qm74	110	11	to	to	IN
cord-015021-pol2qm74	110	12	edematous	edematous	JJ
cord-015021-pol2qm74	110	13	swelling	swelling	NN
cord-015021-pol2qm74	110	14	of	of	IN
cord-015021-pol2qm74	110	15	the	the	DT
cord-015021-pol2qm74	110	16	paw	paw	NN
cord-015021-pol2qm74	110	17	.	.	.
cord-015021-pol2qm74	111	1	CI	CI	NNP
cord-015021-pol2qm74	111	2	-	-	HYPH
cord-015021-pol2qm74	111	3	INH	INH	NNP
cord-015021-pol2qm74	111	4	in	in	IN
cord-015021-pol2qm74	111	5	this	this	DT
cord-015021-pol2qm74	111	6	model	model	NN
cord-015021-pol2qm74	111	7	leads	lead	VBZ
cord-015021-pol2qm74	111	8	to	to	IN
cord-015021-pol2qm74	111	9	a	a	DT
cord-015021-pol2qm74	111	10	dose	dose	NN
cord-015021-pol2qm74	111	11	-	-	HYPH
cord-015021-pol2qm74	111	12	dependent	dependent	JJ
cord-015021-pol2qm74	111	13	decrease	decrease	NN
cord-015021-pol2qm74	111	14	in	in	IN
cord-015021-pol2qm74	111	15	paw	paw	NN
cord-015021-pol2qm74	111	16	edema	edema	NN
cord-015021-pol2qm74	111	17	formation	formation	NN
cord-015021-pol2qm74	111	18	.	.	.
cord-015021-pol2qm74	112	1	Finally	finally	RB
cord-015021-pol2qm74	112	2	,	,	,
cord-015021-pol2qm74	112	3	we	-PRON-	PRP
cord-015021-pol2qm74	112	4	investigated	investigate	VBD
cord-015021-pol2qm74	112	5	the	the	DT
cord-015021-pol2qm74	112	6	effect	effect	NN
cord-015021-pol2qm74	112	7	of	of	IN
cord-015021-pol2qm74	112	8	CI	CI	NNP
cord-015021-pol2qm74	112	9	-	-	HYPH
cord-015021-pol2qm74	112	10	INH	INH	NNP
cord-015021-pol2qm74	112	11	(	(	-LRB-
cord-015021-pol2qm74	112	12	infusion	infusion	NN
cord-015021-pol2qm74	112	13	(	(	-LRB-
cord-015021-pol2qm74	112	14	100	100	CD
cord-015021-pol2qm74	112	15	-	-	SYM
cord-015021-pol2qm74	112	16	125	125	CD
cord-015021-pol2qm74	112	17	U	U	NNP
cord-015021-pol2qm74	112	18	/	/	SYM
cord-015021-pol2qm74	112	19	kg	kg	NN
cord-015021-pol2qm74	112	20	x	x	SYM
cord-015021-pol2qm74	112	21	h	h	NNP
cord-015021-pol2qm74	112	22	)	)	-RRB-
cord-015021-pol2qm74	112	23	on	on	IN
cord-015021-pol2qm74	112	24	a	a	DT
cord-015021-pol2qm74	112	25	LPS	LPS	NNP
cord-015021-pol2qm74	112	26	-	-	HYPH
cord-015021-pol2qm74	112	27	induced	induce	VBN
cord-015021-pol2qm74	112	28	shock	shock	NN
cord-015021-pol2qm74	112	29	in	in	IN
cord-015021-pol2qm74	112	30	the	the	DT
cord-015021-pol2qm74	112	31	rat	rat	NN
cord-015021-pol2qm74	112	32	by	by	IN
cord-015021-pol2qm74	112	33	combination	combination	NN
cord-015021-pol2qm74	112	34	therapy	therapy	NN
cord-015021-pol2qm74	112	35	with	with	IN
cord-015021-pol2qm74	112	36	the	the	DT
cord-015021-pol2qm74	112	37	antithrombotlc	antithrombotlc	NN
cord-015021-pol2qm74	112	38	agents	agent	NNS
cord-015021-pol2qm74	112	39	antithrombin	antithrombin	NN
cord-015021-pol2qm74	112	40	Ill	Ill	NNP
cord-015021-pol2qm74	112	41	(	(	-LRB-
cord-015021-pol2qm74	112	42	Kybernin	Kybernin	NNP
cord-015021-pol2qm74	112	43	®	®	POS
cord-015021-pol2qm74	112	44	)	)	-RRB-
cord-015021-pol2qm74	112	45	or	or	CC
cord-015021-pol2qm74	112	46	rec	rec	NNP
cord-015021-pol2qm74	112	47	.	.	.
cord-015021-pol2qm74	113	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	113	2	(	(	-LRB-
cord-015021-pol2qm74	113	3	both	both	DT
cord-015021-pol2qm74	113	4	substances	substance	NNS
cord-015021-pol2qm74	113	5	from	from	IN
cord-015021-pol2qm74	113	6	Behringwerke	Behringwerke	NNP
cord-015021-pol2qm74	113	7	)	)	-RRB-
cord-015021-pol2qm74	113	8	.	.	.
cord-015021-pol2qm74	114	1	In	in	IN
cord-015021-pol2qm74	114	2	this	this	DT
cord-015021-pol2qm74	114	3	animal	animal	NN
cord-015021-pol2qm74	114	4	model	model	NN
cord-015021-pol2qm74	114	5	mortality	mortality	NN
cord-015021-pol2qm74	114	6	was	be	VBD
cord-015021-pol2qm74	114	7	90	90	CD
cord-015021-pol2qm74	114	8	%	%	NN
cord-015021-pol2qm74	114	9	in	in	IN
cord-015021-pol2qm74	114	10	the	the	DT
cord-015021-pol2qm74	114	11	untreated	untreated	JJ
cord-015021-pol2qm74	114	12	control	control	NN
cord-015021-pol2qm74	114	13	.	.	.
cord-015021-pol2qm74	115	1	Both	both	DT
cord-015021-pol2qm74	115	2	antithrombotic	antithrombotic	JJ
cord-015021-pol2qm74	115	3	agents	agent	NNS
cord-015021-pol2qm74	115	4	decreased	decrease	VBD
cord-015021-pol2qm74	115	5	mortality	mortality	NN
cord-015021-pol2qm74	115	6	rates	rate	NNS
cord-015021-pol2qm74	115	7	by	by	IN
cord-015021-pol2qm74	115	8	inhibiting	inhibit	VBG
cord-015021-pol2qm74	115	9	formation	formation	NN
cord-015021-pol2qm74	115	10	of	of	IN
cord-015021-pol2qm74	115	11	DIC	DIC	NNP
cord-015021-pol2qm74	115	12	;	;	:
cord-015021-pol2qm74	115	13	a	a	DT
cord-015021-pol2qm74	115	14	further	further	JJ
cord-015021-pol2qm74	115	15	significant	significant	JJ
cord-015021-pol2qm74	115	16	improvement	improvement	NN
cord-015021-pol2qm74	115	17	of	of	IN
cord-015021-pol2qm74	115	18	survival	survival	NN
cord-015021-pol2qm74	115	19	was	be	VBD
cord-015021-pol2qm74	115	20	achieved	achieve	VBN
cord-015021-pol2qm74	115	21	by	by	IN
cord-015021-pol2qm74	115	22	the	the	DT
cord-015021-pol2qm74	115	23	treatment	treatment	NN
cord-015021-pol2qm74	115	24	with	with	IN
cord-015021-pol2qm74	115	25	CI	CI	NNP
cord-015021-pol2qm74	115	26	-	-	HYPH
cord-015021-pol2qm74	115	27	INH	INH	NNP
cord-015021-pol2qm74	115	28	.	.	.
cord-015021-pol2qm74	116	1	Thus+	Thus+	NNP
cord-015021-pol2qm74	117	1	it	-PRON-	PRP
cord-015021-pol2qm74	117	2	could	could	MD
cord-015021-pol2qm74	117	3	be	be	VB
cord-015021-pol2qm74	117	4	concluded	conclude	VBN
cord-015021-pol2qm74	117	5	that	that	IN
cord-015021-pol2qm74	117	6	C1-INH	C1-INH	NNP
cord-015021-pol2qm74	117	7	has	have	VBZ
cord-015021-pol2qm74	117	8	a	a	DT
cord-015021-pol2qm74	117	9	beneficial	beneficial	JJ
cord-015021-pol2qm74	117	10	effect	effect	NN
cord-015021-pol2qm74	117	11	in	in	IN
cord-015021-pol2qm74	117	12	diseases	disease	NNS
cord-015021-pol2qm74	117	13	associated	associate	VBN
cord-015021-pol2qm74	117	14	with	with	IN
cord-015021-pol2qm74	117	15	a	a	DT
cord-015021-pol2qm74	117	16	vascular	vascular	JJ
cord-015021-pol2qm74	117	17	leakage	leakage	NN
cord-015021-pol2qm74	117	18	.	.	.
cord-015021-pol2qm74	118	1	ICLB	ICLB	NNP
cord-015021-pol2qm74	118	2	and	and	CC
cord-015021-pol2qm74	118	3	Laboratory	Laboratory	NNP
cord-015021-pol2qm74	118	4	for	for	IN
cord-015021-pol2qm74	118	5	Experimental	Experimental	NNP
cord-015021-pol2qm74	118	6	and	and	CC
cord-015021-pol2qm74	118	7	Clinical	Clinical	NNP
cord-015021-pol2qm74	118	8	Immunology	Immunology	NNP
cord-015021-pol2qm74	118	9	,	,	,
cord-015021-pol2qm74	118	10	University	University	NNP
cord-015021-pol2qm74	118	11	of	of	IN
cord-015021-pol2qm74	118	12	Amsterdam	Amsterdam	NNP
cord-015021-pol2qm74	118	13	,	,	,
cord-015021-pol2qm74	118	14	The	the	DT
cord-015021-pol2qm74	118	15	Netherlands	Netherlands	NNP
cord-015021-pol2qm74	118	16	;	;	:
cord-015021-pol2qm74	118	17	2Thrombosis	2thrombosis	CD
cord-015021-pol2qm74	118	18	Research	Research	NNP
cord-015021-pol2qm74	118	19	Center	Center	NNP
cord-015021-pol2qm74	118	20	,	,	,
cord-015021-pol2qm74	118	21	Temple	Temple	NNP
cord-015021-pol2qm74	118	22	University	University	NNP
cord-015021-pol2qm74	118	23	,	,	,
cord-015021-pol2qm74	118	24	Penn	Penn	NNP
cord-015021-pol2qm74	118	25	.	.	NNP
cord-015021-pol2qm74	118	26	,	,	,
cord-015021-pol2qm74	118	27	USA	USA	NNP
cord-015021-pol2qm74	118	28	;	;	:
cord-015021-pol2qm74	118	29	3Oklahoma	3Oklahoma	NNP
cord-015021-pol2qm74	118	30	Medical	Medical	NNP
cord-015021-pol2qm74	118	31	Research	Research	NNP
cord-015021-pol2qm74	118	32	Foundation	Foundation	NNP
cord-015021-pol2qm74	118	33	,	,	,
cord-015021-pol2qm74	118	34	.	.	.
cord-015021-pol2qm74	119	1	Ok	ok	UH
cord-015021-pol2qm74	119	2	.	.	.
cord-015021-pol2qm74	120	1	City	City	NNP
cord-015021-pol2qm74	120	2	,	,	,
cord-015021-pol2qm74	120	3	USA	USA	NNP
cord-015021-pol2qm74	120	4	.	.	.
cord-015021-pol2qm74	121	1	To	to	TO
cord-015021-pol2qm74	121	2	evaluate	evaluate	VB
cord-015021-pol2qm74	121	3	the	the	DT
cord-015021-pol2qm74	121	4	contribution	contribution	NN
cord-015021-pol2qm74	121	5	of	of	IN
cord-015021-pol2qm74	121	6	the	the	DT
cord-015021-pol2qm74	121	7	contact	contact	NN
cord-015021-pol2qm74	121	8	system	system	NN
cord-015021-pol2qm74	121	9	to	to	TO
cord-015021-pol2qm74	121	10	activation	activation	NN
cord-015021-pol2qm74	121	11	of	of	IN
cord-015021-pol2qm74	121	12	other	other	JJ
cord-015021-pol2qm74	121	13	mediator	mediator	NN
cord-015021-pol2qm74	121	14	systems	system	NNS
cord-015021-pol2qm74	121	15	in	in	IN
cord-015021-pol2qm74	121	16	an	an	DT
cord-015021-pol2qm74	121	17	experimental	experimental	JJ
cord-015021-pol2qm74	121	18	model	model	NN
cord-015021-pol2qm74	121	19	of	of	IN
cord-015021-pol2qm74	121	20	sepsis	sepsis	NN
cord-015021-pol2qm74	121	21	,	,	,
cord-015021-pol2qm74	121	22	we	-PRON-	PRP
cord-015021-pol2qm74	121	23	investigated	investigate	VBD
cord-015021-pol2qm74	121	24	the	the	DT
cord-015021-pol2qm74	121	25	effect	effect	NN
cord-015021-pol2qm74	121	26	of	of	IN
cord-015021-pol2qm74	121	27	mAb	mab	NN
cord-015021-pol2qm74	121	28	C6B7	C6B7	NNP
cord-015021-pol2qm74	121	29	which	which	WDT
cord-015021-pol2qm74	121	30	inhibits	inhibit	VBZ
cord-015021-pol2qm74	121	31	activation	activation	NN
cord-015021-pol2qm74	121	32	of	of	IN
cord-015021-pol2qm74	121	33	factor	factor	NN
cord-015021-pol2qm74	121	34	XlI	xli	NN
cord-015021-pol2qm74	121	35	,	,	,
cord-015021-pol2qm74	121	36	on	on	IN
cord-015021-pol2qm74	121	37	activation	activation	NN
cord-015021-pol2qm74	121	38	of	of	IN
cord-015021-pol2qm74	121	39	complement	complement	NN
cord-015021-pol2qm74	121	40	and	and	CC
cord-015021-pol2qm74	121	41	fibrinolytic	fibrinolytic	JJ
cord-015021-pol2qm74	121	42	cascades	cascade	NNS
cord-015021-pol2qm74	121	43	and	and	CC
cord-015021-pol2qm74	121	44	activation	activation	NN
cord-015021-pol2qm74	121	45	of	of	IN
cord-015021-pol2qm74	121	46	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	121	47	in	in	IN
cord-015021-pol2qm74	121	48	baboons	baboon	NNS
cord-015021-pol2qm74	121	49	suffering	suffer	VBG
cord-015021-pol2qm74	121	50	from	from	IN
cord-015021-pol2qm74	121	51	a	a	DT
cord-015021-pol2qm74	121	52	lethal	lethal	JJ
cord-015021-pol2qm74	121	53	sepsis	sepsis	NN
cord-015021-pol2qm74	121	54	.	.	.
cord-015021-pol2qm74	122	1	Activation	activation	NN
cord-015021-pol2qm74	122	2	of	of	IN
cord-015021-pol2qm74	122	3	the	the	DT
cord-015021-pol2qm74	122	4	complement	complement	NN
cord-015021-pol2qm74	122	5	system	system	NN
cord-015021-pol2qm74	122	6	was	be	VBD
cord-015021-pol2qm74	122	7	assessed	assess	VBN
cord-015021-pol2qm74	122	8	by	by	IN
cord-015021-pol2qm74	122	9	measuring	measure	VBG
cord-015021-pol2qm74	122	10	circulating	circulate	VBG
cord-015021-pol2qm74	122	11	levels	level	NNS
cord-015021-pol2qm74	122	12	of	of	IN
cord-015021-pol2qm74	122	13	C3b	c3b	NN
cord-015021-pol2qm74	122	14	/	/	SYM
cord-015021-pol2qm74	122	15	c	c	NN
cord-015021-pol2qm74	122	16	and	and	CC
cord-015021-pol2qm74	122	17	C4b	C4b	NNP
cord-015021-pol2qm74	122	18	/	/	SYM
cord-015021-pol2qm74	122	19	c	c	NN
cord-015021-pol2qm74	122	20	,	,	,
cord-015021-pol2qm74	122	21	and	and	CC
cord-015021-pol2qm74	122	22	a	a	DT
cord-015021-pol2qm74	122	23	significant	significant	JJ
cord-015021-pol2qm74	122	24	reduction	reduction	NN
cord-015021-pol2qm74	122	25	was	be	VBD
cord-015021-pol2qm74	122	26	observed	observe	VBN
cord-015021-pol2qm74	122	27	in	in	IN
cord-015021-pol2qm74	122	28	5	5	CD
cord-015021-pol2qm74	122	29	animals	animal	NNS
cord-015021-pol2qm74	122	30	that	that	WDT
cord-015021-pol2qm74	122	31	had	have	VBD
cord-015021-pol2qm74	122	32	received	receive	VBN
cord-015021-pol2qm74	122	33	a	a	DT
cord-015021-pol2qm74	122	34	lethal	lethal	JJ
cord-015021-pol2qm74	122	35	dose	dose	NN
cord-015021-pol2qm74	122	36	of	of	IN
cord-015021-pol2qm74	122	37	E.	E.	NNP
cord-015021-pol2qm74	122	38	coli	coli	NNS
cord-015021-pol2qm74	122	39	together	together	RB
cord-015021-pol2qm74	122	40	with	with	IN
cord-015021-pol2qm74	122	41	mAb	mAb	NNP
cord-015021-pol2qm74	122	42	C687	C687	NNP
cord-015021-pol2qm74	122	43	(	(	-LRB-
cord-015021-pol2qm74	122	44	treatment	treatment	NN
cord-015021-pol2qm74	122	45	group	group	NN
cord-015021-pol2qm74	122	46	)	)	-RRB-
cord-015021-pol2qm74	122	47	,	,	,
cord-015021-pol2qm74	122	48	compared	compare	VBN
cord-015021-pol2qm74	122	49	to	to	IN
cord-015021-pol2qm74	122	50	4	4	CD
cord-015021-pol2qm74	122	51	animals	animal	NNS
cord-015021-pol2qm74	122	52	that	that	WDT
cord-015021-pol2qm74	122	53	had	have	VBD
cord-015021-pol2qm74	122	54	received	receive	VBN
cord-015021-pol2qm74	122	55	a	a	DT
cord-015021-pol2qm74	122	56	lethal	lethal	JJ
cord-015021-pol2qm74	122	57	dose	dose	NN
cord-015021-pol2qm74	122	58	of	of	IN
cord-015021-pol2qm74	122	59	E.	E.	NNP
cord-015021-pol2qm74	122	60	coil	coil	NN
cord-015021-pol2qm74	122	61	only	only	RB
cord-015021-pol2qm74	122	62	(	(	-LRB-
cord-015021-pol2qm74	122	63	control	control	NN
cord-015021-pol2qm74	122	64	group	group	NN
cord-015021-pol2qm74	122	65	)	)	-RRB-
cord-015021-pol2qm74	122	66	.	.	.
cord-015021-pol2qm74	123	1	Activation	activation	NN
cord-015021-pol2qm74	123	2	of	of	IN
cord-015021-pol2qm74	123	3	the	the	DT
cord-015021-pol2qm74	123	4	fibrinolytic	fibrinolytic	JJ
cord-015021-pol2qm74	123	5	system	system	NN
cord-015021-pol2qm74	123	6	as	as	IN
cord-015021-pol2qm74	123	7	reflected	reflect	VBN
cord-015021-pol2qm74	123	8	by	by	IN
cord-015021-pol2qm74	123	9	circulating	circulate	VBG
cord-015021-pol2qm74	123	10	plasmin-=2antiplasmin	plasmin-=2antiplasmin	NN
cord-015021-pol2qm74	123	11	complexes	complex	NNS
cord-015021-pol2qm74	123	12	and	and	CC
cord-015021-pol2qm74	123	13	tissue	tissue	NN
cord-015021-pol2qm74	123	14	plasminogen	plasminogen	NN
cord-015021-pol2qm74	123	15	activator	activator	NN
cord-015021-pol2qm74	123	16	,	,	,
cord-015021-pol2qm74	123	17	and	and	CC
cord-015021-pol2qm74	123	18	activation	activation	NN
cord-015021-pol2qm74	123	19	of	of	IN
cord-015021-pol2qm74	123	20	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	123	21	,	,	,
cord-015021-pol2qm74	123	22	assessed	assess	VBN
cord-015021-pol2qm74	123	23	by	by	IN
cord-015021-pol2qm74	123	24	measuring	measure	VBG
cord-015021-pol2qm74	123	25	circulating	circulate	VBG
cord-015021-pol2qm74	123	26	elastase-=l	elastase-=l	NNS
cord-015021-pol2qm74	123	27	-	-	HYPH
cord-015021-pol2qm74	123	28	antitrypsin	antitrypsin	NN
cord-015021-pol2qm74	123	29	complexes	complex	NNS
cord-015021-pol2qm74	123	30	,	,	,
cord-015021-pol2qm74	123	31	was	be	VBD
cord-015021-pol2qm74	123	32	also	also	RB
cord-015021-pol2qm74	123	33	significantly	significantly	RB
cord-015021-pol2qm74	123	34	less	less	JJR
cord-015021-pol2qm74	123	35	in	in	IN
cord-015021-pol2qm74	123	36	the	the	DT
cord-015021-pol2qm74	123	37	treatment	treatment	NN
cord-015021-pol2qm74	123	38	group	group	NN
cord-015021-pol2qm74	123	39	.	.	.
cord-015021-pol2qm74	124	1	We	-PRON-	PRP
cord-015021-pol2qm74	124	2	conclude	conclude	VBP
cord-015021-pol2qm74	124	3	that	that	IN
cord-015021-pol2qm74	124	4	activation	activation	NN
cord-015021-pol2qm74	124	5	of	of	IN
cord-015021-pol2qm74	124	6	the	the	DT
cord-015021-pol2qm74	124	7	contact	contact	NN
cord-015021-pol2qm74	124	8	system	system	NN
cord-015021-pol2qm74	124	9	protein	protein	NN
cord-015021-pol2qm74	124	10	factor	factor	NN
cord-015021-pol2qm74	124	11	Xll	Xll	NNP
cord-015021-pol2qm74	124	12	during	during	IN
cord-015021-pol2qm74	124	13	the	the	DT
cord-015021-pol2qm74	124	14	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	124	15	response	response	NN
cord-015021-pol2qm74	124	16	to	to	IN
cord-015021-pol2qm74	124	17	a	a	DT
cord-015021-pol2qm74	124	18	lethal	lethal	JJ
cord-015021-pol2qm74	124	19	dose	dose	NN
cord-015021-pol2qm74	124	20	of	of	IN
cord-015021-pol2qm74	124	21	E.	E.	NNP
cord-015021-pol2qm74	124	22	coil	coil	NN
cord-015021-pol2qm74	124	23	in	in	IN
cord-015021-pol2qm74	124	24	this	this	DT
cord-015021-pol2qm74	124	25	baboon	baboon	NN
cord-015021-pol2qm74	124	26	model	model	NN
cord-015021-pol2qm74	124	27	,	,	,
cord-015021-pol2qm74	124	28	modulates	modulate	VBZ
cord-015021-pol2qm74	124	29	directly	directly	RB
cord-015021-pol2qm74	124	30	or	or	CC
cord-015021-pol2qm74	124	31	indirectly	indirectly	RB
cord-015021-pol2qm74	124	32	activation	activation	NN
cord-015021-pol2qm74	124	33	of	of	IN
cord-015021-pol2qm74	124	34	the	the	DT
cord-015021-pol2qm74	124	35	complement	complement	NN
cord-015021-pol2qm74	124	36	and	and	CC
cord-015021-pol2qm74	124	37	fibrinolytic	fibrinolytic	JJ
cord-015021-pol2qm74	124	38	systems	system	NNS
cord-015021-pol2qm74	124	39	and	and	CC
cord-015021-pol2qm74	124	40	that	that	IN
cord-015021-pol2qm74	124	41	of	of	IN
cord-015021-pol2qm74	124	42	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	124	43	.	.	.
cord-015021-pol2qm74	125	1	In	in	IN
cord-015021-pol2qm74	125	2	a	a	DT
cord-015021-pol2qm74	125	3	prospective	prospective	JJ
cord-015021-pol2qm74	125	4	study	study	NN
cord-015021-pol2qm74	125	5	,	,	,
cord-015021-pol2qm74	125	6	plasma	plasma	NN
cord-015021-pol2qm74	125	7	levels	level	NNS
cord-015021-pol2qm74	125	8	of	of	IN
cord-015021-pol2qm74	125	9	C3a	C3a	NNP
cord-015021-pol2qm74	125	10	,	,	,
cord-015021-pol2qm74	125	11	C3	C3	NNP
cord-015021-pol2qm74	125	12	,	,	,
cord-015021-pol2qm74	125	13	and	and	CC
cord-015021-pol2qm74	125	14	C5a	C5a	NNS
cord-015021-pol2qm74	125	15	were	be	VBD
cord-015021-pol2qm74	125	16	measured	measure	VBN
cord-015021-pol2qm74	125	17	in	in	IN
cord-015021-pol2qm74	125	18	30	30	CD
cord-015021-pol2qm74	125	19	patients	patient	NNS
cord-015021-pol2qm74	125	20	from	from	IN
cord-015021-pol2qm74	125	21	an	an	DT
cord-015021-pol2qm74	125	22	internal	internal	JJ
cord-015021-pol2qm74	125	23	intensive	intensive	JJ
cord-015021-pol2qm74	125	24	care	care	NN
cord-015021-pol2qm74	125	25	unit	unit	NN
cord-015021-pol2qm74	125	26	.	.	.
cord-015021-pol2qm74	126	1	20	20	CD
cord-015021-pol2qm74	126	2	patients	patient	NNS
cord-015021-pol2qm74	126	3	were	be	VBD
cord-015021-pol2qm74	126	4	clinically	clinically	RB
cord-015021-pol2qm74	126	5	septic	septic	JJ
cord-015021-pol2qm74	126	6	defined	define	VBN
cord-015021-pol2qm74	126	7	by	by	IN
cord-015021-pol2qm74	126	8	the	the	DT
cord-015021-pol2qm74	126	9	criteria	criterion	NNS
cord-015021-pol2qm74	126	10	of	of	IN
cord-015021-pol2qm74	126	11	Bone	Bone	NNP
cord-015021-pol2qm74	126	12	et	et	NNP
cord-015021-pol2qm74	126	13	al.(l	al.(l	NNP
cord-015021-pol2qm74	126	14	)	)	-RRB-
cord-015021-pol2qm74	126	15	.	.	.
cord-015021-pol2qm74	127	1	The	the	DT
cord-015021-pol2qm74	127	2	remaining	remain	VBG
cord-015021-pol2qm74	127	3	10	10	CD
cord-015021-pol2qm74	127	4	patients	patient	NNS
cord-015021-pol2qm74	127	5	were	be	VBD
cord-015021-pol2qm74	127	6	critically	critically	RB
cord-015021-pol2qm74	127	7	ill	ill	JJ
cord-015021-pol2qm74	127	8	but	but	CC
cord-015021-pol2qm74	127	9	did	do	VBD
cord-015021-pol2qm74	127	10	n't	not	RB
cord-015021-pol2qm74	127	11	fulfill	fulfill	VB
cord-015021-pol2qm74	127	12	the	the	DT
cord-015021-pol2qm74	127	13	clinical	clinical	JJ
cord-015021-pol2qm74	127	14	criteria	criterion	NNS
cord-015021-pol2qm74	127	15	of	of	IN
cord-015021-pol2qm74	127	16	sepsis	sepsis	NN
cord-015021-pol2qm74	127	17	.	.	.
cord-015021-pol2qm74	128	1	From	from	IN
cord-015021-pol2qm74	128	2	both	both	DT
cord-015021-pol2qm74	128	3	groups	group	NNS
cord-015021-pol2qm74	128	4	of	of	IN
cord-015021-pol2qm74	128	5	patients	patient	NNS
cord-015021-pol2qm74	128	6	blood	blood	NN
cord-015021-pol2qm74	128	7	samples	sample	NNS
cord-015021-pol2qm74	128	8	were	be	VBD
cord-015021-pol2qm74	128	9	taken	take	VBN
cord-015021-pol2qm74	128	10	over	over	RP
cord-015021-pol2qm74	128	11	a	a	DT
cord-015021-pol2qm74	128	12	l0	l0	NNP
cord-015021-pol2qm74	128	13	days	day	NNS
cord-015021-pol2qm74	128	14	period	period	NN
cord-015021-pol2qm74	128	15	.	.	.
cord-015021-pol2qm74	129	1	During	during	IN
cord-015021-pol2qm74	129	2	the	the	DT
cord-015021-pol2qm74	129	3	first	first	JJ
cord-015021-pol2qm74	129	4	3	3	CD
cord-015021-pol2qm74	129	5	days	day	NNS
cord-015021-pol2qm74	129	6	blood	blood	NN
cord-015021-pol2qm74	129	7	samples	sample	NNS
cord-015021-pol2qm74	129	8	were	be	VBD
cord-015021-pol2qm74	129	9	drawn	draw	VBN
cord-015021-pol2qm74	129	10	every	every	DT
cord-015021-pol2qm74	129	11	8	8	CD
cord-015021-pol2qm74	129	12	h	h	NN
cord-015021-pol2qm74	129	13	,	,	,
cord-015021-pol2qm74	129	14	on	on	IN
cord-015021-pol2qm74	129	15	day	day	NN
cord-015021-pol2qm74	129	16	4	4	CD
cord-015021-pol2qm74	129	17	-	-	SYM
cord-015021-pol2qm74	129	18	6	6	CD
cord-015021-pol2qm74	129	19	every	every	DT
cord-015021-pol2qm74	129	20	12	12	CD
cord-015021-pol2qm74	129	21	h	h	NN
cord-015021-pol2qm74	129	22	and	and	CC
cord-015021-pol2qm74	129	23	the	the	DT
cord-015021-pol2qm74	129	24	last	last	JJ
cord-015021-pol2qm74	129	25	4	4	CD
cord-015021-pol2qm74	129	26	days	day	NNS
cord-015021-pol2qm74	129	27	once	once	RB
cord-015021-pol2qm74	129	28	daily	daily	RB
cord-015021-pol2qm74	129	29	.	.	.
cord-015021-pol2qm74	130	1	Mean	mean	JJ
cord-015021-pol2qm74	130	2	plasma	plasma	NN
cord-015021-pol2qm74	130	3	concentrations	concentration	NNS
cord-015021-pol2qm74	130	4	of	of	IN
cord-015021-pol2qm74	130	5	C3a	C3a	NNPS
cord-015021-pol2qm74	130	6	within	within	IN
cord-015021-pol2qm74	130	7	the	the	DT
cord-015021-pol2qm74	130	8	first	first	JJ
cord-015021-pol2qm74	130	9	32	32	CD
cord-015021-pol2qm74	130	10	h	h	NN
cord-015021-pol2qm74	130	11	after	after	IN
cord-015021-pol2qm74	130	12	clinical	clinical	JJ
cord-015021-pol2qm74	130	13	onset	onset	NN
cord-015021-pol2qm74	130	14	of	of	IN
cord-015021-pol2qm74	130	15	sepsis	sepsis	NN
cord-015021-pol2qm74	130	16	were	be	VBD
cord-015021-pol2qm74	130	17	1019	1019	CD
cord-015021-pol2qm74	130	18	+	+	SYM
cord-015021-pol2qm74	130	19	618	618	CD
cord-015021-pol2qm74	130	20	pg	pg	NN
cord-015021-pol2qm74	130	21	/	/	SYM
cord-015021-pol2qm74	130	22	ml	ml	NNS
cord-015021-pol2qm74	130	23	,	,	,
cord-015021-pol2qm74	130	24	whereas	whereas	IN
cord-015021-pol2qm74	130	25	non	non	JJ
cord-015021-pol2qm74	130	26	-	-	JJ
cord-015021-pol2qm74	130	27	septic	septic	JJ
cord-015021-pol2qm74	130	28	-	-	HYPH
cord-015021-pol2qm74	130	29	patients	patient	NNS
cord-015021-pol2qm74	130	30	exhibited	exhibit	VBD
cord-015021-pol2qm74	130	31	mean	mean	JJ
cord-015021-pol2qm74	130	32	values	value	NNS
cord-015021-pol2qm74	130	33	of	of	IN
cord-015021-pol2qm74	130	34	only	only	RB
cord-015021-pol2qm74	130	35	595	595	CD
cord-015021-pol2qm74	130	36	+	+	CC
cord-015021-pol2qm74	130	37	_	_	NN
cord-015021-pol2qm74	130	38	312	312	CD
cord-015021-pol2qm74	130	39	p_g	p_g	NNP
cord-015021-pol2qm74	130	40	/	/	SYM
cord-015021-pol2qm74	130	41	m/.	m/.	NNP
cord-015021-pol2qm74	130	42	C3	C3	NNP
cord-015021-pol2qm74	130	43	levels	level	NNS
cord-015021-pol2qm74	130	44	were	be	VBD
cord-015021-pol2qm74	130	45	lower	low	JJR
cord-015021-pol2qm74	130	46	for	for	IN
cord-015021-pol2qm74	130	47	septic	septic	NN
cord-015021-pol2qm74	130	48	-	-	HYPH
cord-015021-pol2qm74	130	49	patients	patient	NNS
cord-015021-pol2qm74	130	50	(	(	-LRB-
cord-015021-pol2qm74	130	51	840	840	CD
cord-015021-pol2qm74	130	52	+	+	SYM
cord-015021-pol2qm74	130	53	480	480	CD
cord-015021-pol2qm74	130	54	lag	lag	NN
cord-015021-pol2qm74	130	55	/	/	SYM
cord-015021-pol2qm74	130	56	ml	ml	NN
cord-015021-pol2qm74	130	57	)	)	-RRB-
cord-015021-pol2qm74	130	58	than	than	IN
cord-015021-pol2qm74	130	59	for	for	IN
cord-015021-pol2qm74	130	60	non	non	JJ
cord-015021-pol2qm74	130	61	-	-	JJ
cord-015021-pol2qm74	130	62	septic	septic	JJ
cord-015021-pol2qm74	130	63	-	-	HYPH
cord-015021-pol2qm74	130	64	patients	patient	NNS
cord-015021-pol2qm74	130	65	(	(	-LRB-
cord-015021-pol2qm74	130	66	1340	1340	CD
cord-015021-pol2qm74	130	67	_	_	NN
cord-015021-pol2qm74	130	68	+	+	SYM
cord-015021-pol2qm74	130	69	770	770	CD
cord-015021-pol2qm74	130	70	lag	lag	NN
cord-015021-pol2qm74	130	71	/	/	SYM
cord-015021-pol2qm74	130	72	ml	ml	NN
cord-015021-pol2qm74	130	73	)	)	-RRB-
cord-015021-pol2qm74	130	74	.	.	.
cord-015021-pol2qm74	131	1	The	the	DT
cord-015021-pol2qm74	131	2	most	most	RBS
cord-015021-pol2qm74	131	3	profound	profound	JJ
cord-015021-pol2qm74	131	4	difference	difference	NN
cord-015021-pol2qm74	131	5	between	between	IN
cord-015021-pol2qm74	131	6	both	both	DT
cord-015021-pol2qm74	131	7	groups	group	NNS
cord-015021-pol2qm74	131	8	was	be	VBD
cord-015021-pol2qm74	131	9	found	find	VBN
cord-015021-pol2qm74	131	10	,	,	,
cord-015021-pol2qm74	131	11	when	when	WRB
cord-015021-pol2qm74	131	12	the	the	DT
cord-015021-pol2qm74	131	13	C3a	C3a	NNP
cord-015021-pol2qm74	131	14	/	/	SYM
cord-015021-pol2qm74	131	15	C3	c3	NN
cord-015021-pol2qm74	131	16	ratio	ratio	NN
cord-015021-pol2qm74	131	17	was	be	VBD
cord-015021-pol2qm74	131	18	compared	compare	VBN
cord-015021-pol2qm74	131	19	(	(	-LRB-
cord-015021-pol2qm74	131	20	1.84	1.84	CD
cord-015021-pol2qm74	131	21	+	+	SYM
cord-015021-pol2qm74	131	22	2.28	2.28	CD
cord-015021-pol2qm74	131	23	for	for	IN
cord-015021-pol2qm74	131	24	septic	septic	NN
cord-015021-pol2qm74	131	25	-	-	HYPH
cord-015021-pol2qm74	131	26	patients	patient	NNS
cord-015021-pol2qm74	131	27	and	and	CC
cord-015021-pol2qm74	132	1	0.4	0.4	CD
cord-015021-pol2qm74	132	2	_	_	NN
cord-015021-pol2qm74	132	3	+	+	CC
cord-015021-pol2qm74	133	1	_	_	NNP
cord-015021-pol2qm74	133	2	0.18	0.18	CD
cord-015021-pol2qm74	133	3	for	for	IN
cord-015021-pol2qm74	133	4	the	the	DT
cord-015021-pol2qm74	133	5	control	control	NN
cord-015021-pol2qm74	133	6	group	group	NN
cord-015021-pol2qm74	133	7	)	)	-RRB-
cord-015021-pol2qm74	133	8	.	.	.
cord-015021-pol2qm74	134	1	No	no	DT
cord-015021-pol2qm74	134	2	significant	significant	JJ
cord-015021-pol2qm74	134	3	differences	difference	NNS
cord-015021-pol2qm74	134	4	between	between	IN
cord-015021-pol2qm74	134	5	both	both	DT
cord-015021-pol2qm74	134	6	patient	patient	JJ
cord-015021-pol2qm74	134	7	groups	group	NNS
cord-015021-pol2qm74	134	8	were	be	VBD
cord-015021-pol2qm74	134	9	observed	observe	VBN
cord-015021-pol2qm74	134	10	in	in	IN
cord-015021-pol2qm74	134	11	C5a	C5a	NNS
cord-015021-pol2qm74	134	12	plasma	plasma	NN
cord-015021-pol2qm74	134	13	levels	level	NNS
cord-015021-pol2qm74	134	14	(	(	-LRB-
cord-015021-pol2qm74	134	15	5.9	5.9	CD
cord-015021-pol2qm74	134	16	+	+	SYM
cord-015021-pol2qm74	134	17	2.1	2.1	CD
cord-015021-pol2qm74	134	18	ng	ng	NN
cord-015021-pol2qm74	134	19	/	/	SYM
cord-015021-pol2qm74	134	20	ml	ml	NN
cord-015021-pol2qm74	134	21	in	in	IN
cord-015021-pol2qm74	134	22	septic	septic	JJ
cord-015021-pol2qm74	134	23	-	-	HYPH
cord-015021-pol2qm74	134	24	patients	patient	NNS
cord-015021-pol2qm74	134	25	vs.	vs.	IN
cord-015021-pol2qm74	135	1	5.6	5.6	CD
cord-015021-pol2qm74	135	2	_	_	NN
cord-015021-pol2qm74	135	3	+	+	CC
cord-015021-pol2qm74	136	1	1.5	1.5	CD
cord-015021-pol2qm74	136	2	ng	ng	NN
cord-015021-pol2qm74	136	3	/	/	SYM
cord-015021-pol2qm74	136	4	ml	ml	NN
cord-015021-pol2qm74	136	5	in	in	IN
cord-015021-pol2qm74	136	6	control	control	NN
cord-015021-pol2qm74	136	7	patients	patient	NNS
cord-015021-pol2qm74	136	8	)	)	-RRB-
cord-015021-pol2qm74	136	9	.	.	.
cord-015021-pol2qm74	137	1	In	in	IN
cord-015021-pol2qm74	137	2	13	13	CD
cord-015021-pol2qm74	137	3	of	of	IN
cord-015021-pol2qm74	137	4	20	20	CD
cord-015021-pol2qm74	137	5	cases	case	NNS
cord-015021-pol2qm74	137	6	of	of	IN
cord-015021-pol2qm74	137	7	clinically	clinically	RB
cord-015021-pol2qm74	137	8	defined	define	VBN
cord-015021-pol2qm74	137	9	sepsis	sepsis	NN
cord-015021-pol2qm74	137	10	causative	causative	JJ
cord-015021-pol2qm74	137	11	organisms	organism	NNS
cord-015021-pol2qm74	137	12	like	like	IN
cord-015021-pol2qm74	137	13	bacteria	bacteria	NNS
cord-015021-pol2qm74	137	14	,	,	,
cord-015021-pol2qm74	137	15	protozoa	protozoan	NNS
cord-015021-pol2qm74	137	16	or	or	CC
cord-015021-pol2qm74	137	17	fungi	fungus	NNS
cord-015021-pol2qm74	137	18	could	could	MD
cord-015021-pol2qm74	137	19	be	be	VB
cord-015021-pol2qm74	137	20	cultured	culture	VBN
cord-015021-pol2qm74	137	21	from	from	IN
cord-015021-pol2qm74	137	22	blood	blood	NN
cord-015021-pol2qm74	137	23	,	,	,
cord-015021-pol2qm74	137	24	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	137	25	lavages	lavage	NNS
cord-015021-pol2qm74	137	26	and/or	and/or	CC
cord-015021-pol2qm74	137	27	section	section	NN
cord-015021-pol2qm74	137	28	materials	material	NNS
cord-015021-pol2qm74	137	29	.	.	.
cord-015021-pol2qm74	138	1	Application	application	NN
cord-015021-pol2qm74	138	2	of	of	IN
cord-015021-pol2qm74	138	3	the	the	DT
cord-015021-pol2qm74	138	4	complement	complement	NN
cord-015021-pol2qm74	138	5	parameters	parameter	NNS
cord-015021-pol2qm74	138	6	to	to	IN
cord-015021-pol2qm74	138	7	survivors	survivor	NNS
cord-015021-pol2qm74	138	8	(	(	-LRB-
cord-015021-pol2qm74	138	9	n=9	n=9	NN
cord-015021-pol2qm74	138	10	)	)	-RRB-
cord-015021-pol2qm74	138	11	and	and	CC
cord-015021-pol2qm74	138	12	non	non	NNS
cord-015021-pol2qm74	138	13	-	-	NNS
cord-015021-pol2qm74	138	14	survivors	survivor	NNS
cord-015021-pol2qm74	138	15	(	(	-LRB-
cord-015021-pol2qm74	138	16	n	n	NN
cord-015021-pol2qm74	138	17	=	=	SYM
cord-015021-pol2qm74	138	18	l	l	NN
cord-015021-pol2qm74	138	19	1	1	CD
cord-015021-pol2qm74	138	20	)	)	-RRB-
cord-015021-pol2qm74	138	21	within	within	IN
cord-015021-pol2qm74	138	22	the	the	DT
cord-015021-pol2qm74	138	23	septic	septic	JJ
cord-015021-pol2qm74	138	24	-	-	HYPH
cord-015021-pol2qm74	138	25	group	group	NN
cord-015021-pol2qm74	138	26	revealed	reveal	VBD
cord-015021-pol2qm74	138	27	,	,	,
cord-015021-pol2qm74	138	28	that	that	IN
cord-015021-pol2qm74	138	29	the	the	DT
cord-015021-pol2qm74	138	30	C3a	C3a	NNP
cord-015021-pol2qm74	138	31	/	/	SYM
cord-015021-pol2qm74	138	32	C3	c3	NN
cord-015021-pol2qm74	138	33	ratio	ratio	NN
cord-015021-pol2qm74	138	34	could	could	MD
cord-015021-pol2qm74	138	35	also	also	RB
cord-015021-pol2qm74	138	36	be	be	VB
cord-015021-pol2qm74	138	37	used	use	VBN
cord-015021-pol2qm74	138	38	as	as	IN
cord-015021-pol2qm74	138	39	a	a	DT
cord-015021-pol2qm74	138	40	prognostic	prognostic	JJ
cord-015021-pol2qm74	138	41	parameter	parameter	NN
cord-015021-pol2qm74	138	42	for	for	IN
cord-015021-pol2qm74	138	43	clinical	clinical	JJ
cord-015021-pol2qm74	138	44	outcome	outcome	NN
cord-015021-pol2qm74	138	45	.	.	.
cord-015021-pol2qm74	139	1	The	the	DT
cord-015021-pol2qm74	139	2	possibility	possibility	NN
cord-015021-pol2qm74	139	3	of	of	IN
cord-015021-pol2qm74	139	4	rapid	rapid	JJ
cord-015021-pol2qm74	139	5	and	and	CC
cord-015021-pol2qm74	139	6	easy	easy	JJ
cord-015021-pol2qm74	139	7	measurement	measurement	NN
cord-015021-pol2qm74	139	8	of	of	IN
cord-015021-pol2qm74	139	9	C3a	C3a	NNP
cord-015021-pol2qm74	139	10	and	and	CC
cord-015021-pol2qm74	139	11	C3	C3	NNP
cord-015021-pol2qm74	139	12	in	in	IN
cord-015021-pol2qm74	139	13	only	only	RB
cord-015021-pol2qm74	139	14	20	20	CD
cord-015021-pol2qm74	139	15	-	-	SYM
cord-015021-pol2qm74	139	16	25	25	CD
cord-015021-pol2qm74	139	17	minutes	minute	NNS
cord-015021-pol2qm74	139	18	(	(	-LRB-
cord-015021-pol2qm74	139	19	2	2	CD
cord-015021-pol2qm74	139	20	)	)	-RRB-
cord-015021-pol2qm74	139	21	and	and	CC
cord-015021-pol2qm74	139	22	the	the	DT
cord-015021-pol2qm74	139	23	significant	significant	JJ
cord-015021-pol2qm74	139	24	difference	difference	NN
cord-015021-pol2qm74	139	25	of	of	IN
cord-015021-pol2qm74	139	26	the	the	DT
cord-015021-pol2qm74	139	27	C3aJC3	C3aJC3	NNP
cord-015021-pol2qm74	139	28	ratio	ratio	NN
cord-015021-pol2qm74	139	29	between	between	IN
cord-015021-pol2qm74	139	30	the	the	DT
cord-015021-pol2qm74	139	31	septic	septic	JJ
cord-015021-pol2qm74	139	32	and	and	CC
cord-015021-pol2qm74	139	33	non	non	JJ
cord-015021-pol2qm74	139	34	-	-	JJ
cord-015021-pol2qm74	139	35	septic	septic	JJ
cord-015021-pol2qm74	139	36	group	group	NN
cord-015021-pol2qm74	139	37	renders	render	VBZ
cord-015021-pol2qm74	139	38	this	this	DT
cord-015021-pol2qm74	139	39	parameter	parameter	NN
cord-015021-pol2qm74	139	40	a	a	DT
cord-015021-pol2qm74	139	41	good	good	JJ
cord-015021-pol2qm74	139	42	candidate	candidate	NN
cord-015021-pol2qm74	139	43	for	for	IN
cord-015021-pol2qm74	139	44	early	early	JJ
cord-015021-pol2qm74	139	45	diagnosis	diagnosis	NN
cord-015021-pol2qm74	139	46	of	of	IN
cord-015021-pol2qm74	139	47	sepsis	sepsis	NN
cord-015021-pol2qm74	139	48	in	in	IN
cord-015021-pol2qm74	139	49	the	the	DT
cord-015021-pol2qm74	139	50	intensive	intensive	JJ
cord-015021-pol2qm74	139	51	care	care	NN
cord-015021-pol2qm74	139	52	unit	unit	NN
cord-015021-pol2qm74	139	53	.	.	.
cord-015021-pol2qm74	140	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	140	2	,	,	,
cord-015021-pol2qm74	140	3	a	a	DT
cord-015021-pol2qm74	140	4	single	single	JJ
cord-015021-pol2qm74	140	5	polypeptide	polypeptide	NN
cord-015021-pol2qm74	140	6	chain	chain	NN
cord-015021-pol2qm74	140	7	composed	compose	VBN
cord-015021-pol2qm74	140	8	of	of	IN
cord-015021-pol2qm74	140	9	65	65	CD
cord-015021-pol2qm74	140	10	amino	amino	JJ
cord-015021-pol2qm74	140	11	acids	acid	NNS
cord-015021-pol2qm74	140	12	with	with	IN
cord-015021-pol2qm74	140	13	6	6	CD
cord-015021-pol2qm74	140	14	cysteine	cysteine	NN
cord-015021-pol2qm74	140	15	residues	residue	NNS
cord-015021-pol2qm74	140	16	(	(	-LRB-
cord-015021-pol2qm74	140	17	MR	MR	NNP
cord-015021-pol2qm74	140	18	7000	7000	CD
cord-015021-pol2qm74	140	19	daitons	daiton	NNS
cord-015021-pol2qm74	140	20	)	)	-RRB-
cord-015021-pol2qm74	140	21	,	,	,
cord-015021-pol2qm74	140	22	is	be	VBZ
cord-015021-pol2qm74	140	23	the	the	DT
cord-015021-pol2qm74	140	24	most	most	RBS
cord-015021-pol2qm74	140	25	potent	potent	JJ
cord-015021-pol2qm74	140	26	and	and	CC
cord-015021-pol2qm74	140	27	specific	specific	JJ
cord-015021-pol2qm74	140	28	thrombin	thrombin	JJ
cord-015021-pol2qm74	140	29	inhibitor	inhibitor	NN
cord-015021-pol2qm74	140	30	,	,	,
cord-015021-pol2qm74	140	31	which	which	WDT
cord-015021-pol2qm74	140	32	is	be	VBZ
cord-015021-pol2qm74	140	33	now	now	RB
cord-015021-pol2qm74	140	34	available	available	JJ
cord-015021-pol2qm74	140	35	as	as	IN
cord-015021-pol2qm74	140	36	a	a	DT
cord-015021-pol2qm74	140	37	genetically	genetically	RB
cord-015021-pol2qm74	140	38	engineered	engineer	VBN
cord-015021-pol2qm74	140	39	product	product	NN
cord-015021-pol2qm74	140	40	(	(	-LRB-
cord-015021-pol2qm74	140	41	rec	rec	NNP
cord-015021-pol2qm74	140	42	.	.	.
cord-015021-pol2qm74	141	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	141	2	-HBW	-HBW	VBD
cord-015021-pol2qm74	141	3	023	023	CD
cord-015021-pol2qm74	141	4	,	,	,
cord-015021-pol2qm74	141	5	Behringwerke	Behringwerke	NNP
cord-015021-pol2qm74	141	6	;	;	:
cord-015021-pol2qm74	141	7	Marburg	Marburg	NNP
cord-015021-pol2qm74	141	8	)	)	-RRB-
cord-015021-pol2qm74	141	9	.	.	.
cord-015021-pol2qm74	142	1	The	the	DT
cord-015021-pol2qm74	142	2	aim	aim	NN
cord-015021-pol2qm74	142	3	of	of	IN
cord-015021-pol2qm74	142	4	our	-PRON-	PRP$
cord-015021-pol2qm74	142	5	study	study	NN
cord-015021-pol2qm74	142	6	was	be	VBD
cord-015021-pol2qm74	142	7	to	to	TO
cord-015021-pol2qm74	142	8	establish	establish	VB
cord-015021-pol2qm74	142	9	a	a	DT
cord-015021-pol2qm74	142	10	rabbit	rabbit	NN
cord-015021-pol2qm74	142	11	model	model	NN
cord-015021-pol2qm74	142	12	of	of	IN
cord-015021-pol2qm74	142	13	tissue	tissue	NN
cord-015021-pol2qm74	142	14	factor	factor	NN
cord-015021-pol2qm74	142	15	(	(	-LRB-
cord-015021-pol2qm74	142	16	TF	TF	NNP
cord-015021-pol2qm74	142	17	)	)	-RRB-
cord-015021-pol2qm74	142	18	induced	induce	VBN
cord-015021-pol2qm74	142	19	activation	activation	NN
cord-015021-pol2qm74	142	20	of	of	IN
cord-015021-pol2qm74	142	21	the	the	DT
cord-015021-pol2qm74	142	22	extrinsic	extrinsic	JJ
cord-015021-pol2qm74	142	23	pathway	pathway	NN
cord-015021-pol2qm74	142	24	of	of	IN
cord-015021-pol2qm74	142	25	coagulation	coagulation	NN
cord-015021-pol2qm74	142	26	and	and	CC
cord-015021-pol2qm74	142	27	to	to	TO
cord-015021-pol2qm74	142	28	evaluate	evaluate	VB
cord-015021-pol2qm74	142	29	the	the	DT
cord-015021-pol2qm74	142	30	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	142	31	efficacy	efficacy	NN
cord-015021-pol2qm74	142	32	of	of	IN
cord-015021-pol2qm74	142	33	rec	rec	NNP
cord-015021-pol2qm74	142	34	.	.	.
cord-015021-pol2qm74	143	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	143	2	.	.	.
cord-015021-pol2qm74	144	1	Coagulation	coagulation	NN
cord-015021-pol2qm74	144	2	was	be	VBD
cord-015021-pol2qm74	144	3	induced	induce	VBN
cord-015021-pol2qm74	144	4	in	in	IN
cord-015021-pol2qm74	144	5	female	female	JJ
cord-015021-pol2qm74	144	6	NZW	NZW	NNP
cord-015021-pol2qm74	144	7	rabbits	rabbit	NNS
cord-015021-pol2qm74	144	8	by	by	IN
cord-015021-pol2qm74	144	9	infusion	infusion	NN
cord-015021-pol2qm74	144	10	of	of	IN
cord-015021-pol2qm74	144	11	0.5	0.5	CD
cord-015021-pol2qm74	144	12	p.g	p.g	NNP
cord-015021-pol2qm74	144	13	/	/	SYM
cord-015021-pol2qm74	144	14	kgxh	kgxh	FW
cord-015021-pol2qm74	144	15	thromboplastin	thromboplastin	NNP
cord-015021-pol2qm74	144	16	for	for	IN
cord-015021-pol2qm74	144	17	7	7	CD
cord-015021-pol2qm74	144	18	hours	hour	NNS
cord-015021-pol2qm74	144	19	.	.	.
cord-015021-pol2qm74	145	1	Development	development	NN
cord-015021-pol2qm74	145	2	of	of	IN
cord-015021-pol2qm74	145	3	disseminated	disseminate	VBN
cord-015021-pol2qm74	145	4	clotting	clotting	NN
cord-015021-pol2qm74	145	5	was	be	VBD
cord-015021-pol2qm74	145	6	manifested	manifest	VBN
cord-015021-pol2qm74	145	7	by	by	IN
cord-015021-pol2qm74	145	8	a	a	DT
cord-015021-pol2qm74	145	9	decrease	decrease	NN
cord-015021-pol2qm74	145	10	of	of	IN
cord-015021-pol2qm74	145	11	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	145	12	and	and	CC
cord-015021-pol2qm74	145	13	platelets	platelet	NNS
cord-015021-pol2qm74	145	14	to	to	IN
cord-015021-pol2qm74	145	15	27.0	27.0	CD
cord-015021-pol2qm74	145	16	%	%	NN
cord-015021-pol2qm74	145	17	and	and	CC
cord-015021-pol2qm74	145	18	33,0	33,0	CD
cord-015021-pol2qm74	145	19	%	%	NN
cord-015021-pol2qm74	145	20	respectively	respectively	RB
cord-015021-pol2qm74	145	21	,	,	,
cord-015021-pol2qm74	145	22	and	and	CC
cord-015021-pol2qm74	145	23	by	by	IN
cord-015021-pol2qm74	145	24	an	an	DT
cord-015021-pol2qm74	145	25	increase	increase	NN
cord-015021-pol2qm74	145	26	of	of	IN
cord-015021-pol2qm74	145	27	fibrin	fibrin	NN
cord-015021-pol2qm74	145	28	monomers	monomer	NNS
cord-015021-pol2qm74	145	29	from	from	IN
cord-015021-pol2qm74	145	30	13.2	13.2	CD
cord-015021-pol2qm74	145	31	to	to	IN
cord-015021-pol2qm74	145	32	>	>	XX
cord-015021-pol2qm74	145	33	85.0	85.0	CD
cord-015021-pol2qm74	145	34	~tg	~tg	NNS
cord-015021-pol2qm74	145	35	/	/	SYM
cord-015021-pol2qm74	145	36	ml	ml	NN
cord-015021-pol2qm74	145	37	.	.	.
cord-015021-pol2qm74	146	1	We	-PRON-	PRP
cord-015021-pol2qm74	146	2	administered	administer	VBD
cord-015021-pol2qm74	146	3	rec	rec	NNP
cord-015021-pol2qm74	146	4	.	.	.
cord-015021-pol2qm74	147	1	Hirudin	hirudin	RB
cord-015021-pol2qm74	147	2	to	to	IN
cord-015021-pol2qm74	147	3	rabbits	rabbit	NNS
cord-015021-pol2qm74	147	4	in	in	IN
cord-015021-pol2qm74	147	5	3	3	CD
cord-015021-pol2qm74	147	6	different	different	JJ
cord-015021-pol2qm74	147	7	concentrations	concentration	NNS
cord-015021-pol2qm74	147	8	(	(	-LRB-
cord-015021-pol2qm74	147	9	0.5	0.5	CD
cord-015021-pol2qm74	147	10	,	,	,
cord-015021-pol2qm74	147	11	1.0	1.0	CD
cord-015021-pol2qm74	147	12	and	and	CC
cord-015021-pol2qm74	147	13	2.0	2.0	CD
cord-015021-pol2qm74	147	14	mg	mg	NNP
cord-015021-pol2qm74	147	15	/	/	SYM
cord-015021-pol2qm74	147	16	kg	kg	NNP
cord-015021-pol2qm74	147	17	)	)	-RRB-
cord-015021-pol2qm74	147	18	;	;	:
cord-015021-pol2qm74	147	19	treatment	treatment	NN
cord-015021-pol2qm74	147	20	started	start	VBD
cord-015021-pol2qm74	147	21	simultaneously	simultaneously	RB
cord-015021-pol2qm74	147	22	with	with	IN
cord-015021-pol2qm74	147	23	the	the	DT
cord-015021-pol2qm74	147	24	infusion	infusion	NN
cord-015021-pol2qm74	147	25	as	as	IN
cord-015021-pol2qm74	147	26	an	an	DT
cord-015021-pol2qm74	147	27	i.v	i.v	NNP
cord-015021-pol2qm74	147	28	.	.	NNP
cord-015021-pol2qm74	147	29	bolus	bolus	NNP
cord-015021-pol2qm74	147	30	.	.	.
cord-015021-pol2qm74	148	1	Rec	Rec	NNP
cord-015021-pol2qm74	148	2	.	.	.
cord-015021-pol2qm74	149	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	149	2	significantly	significantly	RB
cord-015021-pol2qm74	149	3	prevented	prevent	VBD
cord-015021-pol2qm74	149	4	the	the	DT
cord-015021-pol2qm74	149	5	decrease	decrease	NN
cord-015021-pol2qm74	149	6	of	of	IN
cord-015021-pol2qm74	149	7	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	149	8	,	,	,
cord-015021-pol2qm74	149	9	platelets	platelet	NNS
cord-015021-pol2qm74	149	10	and	and	CC
cord-015021-pol2qm74	149	11	the	the	DT
cord-015021-pol2qm74	149	12	increase	increase	NN
cord-015021-pol2qm74	149	13	of	of	IN
cord-015021-pol2qm74	149	14	fibrin	fibrin	NN
cord-015021-pol2qm74	149	15	monomers	monomer	NNS
cord-015021-pol2qm74	149	16	.	.	.
cord-015021-pol2qm74	150	1	This	this	DT
cord-015021-pol2qm74	150	2	effect	effect	NN
cord-015021-pol2qm74	150	3	was	be	VBD
cord-015021-pol2qm74	150	4	dose	dose	JJ
cord-015021-pol2qm74	150	5	dependent	dependent	JJ
cord-015021-pol2qm74	150	6	and	and	CC
cord-015021-pol2qm74	150	7	long	long	RB
cord-015021-pol2qm74	150	8	lasting	lasting	JJ
cord-015021-pol2qm74	150	9	,	,	,
cord-015021-pol2qm74	150	10	even	even	RB
cord-015021-pol2qm74	150	11	7	7	CD
cord-015021-pol2qm74	150	12	hours	hour	NNS
cord-015021-pol2qm74	150	13	after	after	IN
cord-015021-pol2qm74	150	14	the	the	DT
cord-015021-pol2qm74	150	15	administration	administration	NN
cord-015021-pol2qm74	150	16	of	of	IN
cord-015021-pol2qm74	150	17	rec	rec	NNP
cord-015021-pol2qm74	150	18	.	.	.
cord-015021-pol2qm74	151	1	Hirudin	hirudin	RB
cord-015021-pol2qm74	151	2	,	,	,
cord-015021-pol2qm74	151	3	clotting	clotting	NN
cord-015021-pol2qm74	151	4	was	be	VBD
cord-015021-pol2qm74	151	5	still	still	RB
cord-015021-pol2qm74	151	6	significantly	significantly	RB
cord-015021-pol2qm74	151	7	reduced	reduce	VBN
cord-015021-pol2qm74	151	8	.	.	.
cord-015021-pol2qm74	152	1	As	as	IN
cord-015021-pol2qm74	152	2	could	could	MD
cord-015021-pol2qm74	152	3	be	be	VB
cord-015021-pol2qm74	152	4	drawn	draw	VBN
cord-015021-pol2qm74	152	5	from	from	IN
cord-015021-pol2qm74	152	6	the	the	DT
cord-015021-pol2qm74	152	7	plasma	plasma	NN
cord-015021-pol2qm74	152	8	levels	level	NNS
cord-015021-pol2qm74	152	9	,	,	,
cord-015021-pol2qm74	152	10	rec	rec	NNP
cord-015021-pol2qm74	152	11	.	.	.
cord-015021-pol2qm74	153	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	153	2	had	have	VBD
cord-015021-pol2qm74	153	3	been	be	VBN
cord-015021-pol2qm74	153	4	cleared	clear	VBN
cord-015021-pol2qm74	153	5	from	from	IN
cord-015021-pol2qm74	153	6	plasma	plasma	NN
cord-015021-pol2qm74	153	7	at	at	IN
cord-015021-pol2qm74	153	8	this	this	DT
cord-015021-pol2qm74	153	9	time	time	NN
cord-015021-pol2qm74	153	10	.	.	.
cord-015021-pol2qm74	154	1	In	in	IN
cord-015021-pol2qm74	154	2	a	a	DT
cord-015021-pol2qm74	154	3	post	post	JJ
cord-015021-pol2qm74	154	4	-	-	JJ
cord-015021-pol2qm74	154	5	treatment	treatment	JJ
cord-015021-pol2qm74	154	6	study	study	NN
cord-015021-pol2qm74	154	7	we	-PRON-	PRP
cord-015021-pol2qm74	154	8	administered	administer	VBD
cord-015021-pol2qm74	154	9	rec	rec	NNP
cord-015021-pol2qm74	154	10	.	.	.
cord-015021-pol2qm74	155	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	155	2	(	(	-LRB-
cord-015021-pol2qm74	155	3	0.5	0.5	CD
cord-015021-pol2qm74	155	4	,	,	,
cord-015021-pol2qm74	155	5	1.0	1.0	CD
cord-015021-pol2qm74	155	6	and	and	CC
cord-015021-pol2qm74	155	7	2.0	2.0	CD
cord-015021-pol2qm74	155	8	mg	mg	NNP
cord-015021-pol2qm74	155	9	/	/	SYM
cord-015021-pol2qm74	155	10	kg	kg	NNP
cord-015021-pol2qm74	155	11	i.v	i.v	NNP
cord-015021-pol2qm74	155	12	.	.	.
cord-015021-pol2qm74	155	13	bolus	bolus	NNP
cord-015021-pol2qm74	155	14	)	)	-RRB-
cord-015021-pol2qm74	155	15	as	as	RB
cord-015021-pol2qm74	155	16	late	late	JJ
cord-015021-pol2qm74	155	17	as	as	IN
cord-015021-pol2qm74	155	18	2	2	CD
cord-015021-pol2qm74	155	19	hours	hour	NNS
cord-015021-pol2qm74	155	20	after	after	IN
cord-015021-pol2qm74	155	21	the	the	DT
cord-015021-pol2qm74	155	22	start	start	NN
cord-015021-pol2qm74	155	23	of	of	IN
cord-015021-pol2qm74	155	24	TF	TF	NNP
cord-015021-pol2qm74	155	25	infusion	infusion	NN
cord-015021-pol2qm74	155	26	.	.	.
cord-015021-pol2qm74	156	1	At	at	IN
cord-015021-pol2qm74	156	2	this	this	DT
cord-015021-pol2qm74	156	3	time	time	NN
cord-015021-pol2qm74	156	4	there	there	EX
cord-015021-pol2qm74	156	5	was	be	VBD
cord-015021-pol2qm74	156	6	already	already	RB
cord-015021-pol2qm74	156	7	a	a	DT
cord-015021-pol2qm74	156	8	prominent	prominent	JJ
cord-015021-pol2qm74	156	9	activation	activation	NN
cord-015021-pol2qm74	156	10	of	of	IN
cord-015021-pol2qm74	156	11	coagulation	coagulation	NN
cord-015021-pol2qm74	156	12	.	.	.
cord-015021-pol2qm74	157	1	Even	even	RB
cord-015021-pol2qm74	157	2	in	in	IN
cord-015021-pol2qm74	157	3	this	this	DT
cord-015021-pol2qm74	157	4	post	post	JJ
cord-015021-pol2qm74	157	5	-	-	JJ
cord-015021-pol2qm74	157	6	treatment	treatment	JJ
cord-015021-pol2qm74	157	7	regimen	regimen	NN
cord-015021-pol2qm74	157	8	rec	rec	NNP
cord-015021-pol2qm74	157	9	.	.	.
cord-015021-pol2qm74	158	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	158	2	significantly	significantly	RB
cord-015021-pol2qm74	158	3	prevented	prevent	VBD
cord-015021-pol2qm74	158	4	disseminated	disseminate	VBN
cord-015021-pol2qm74	158	5	clotting	clotting	NN
cord-015021-pol2qm74	158	6	.	.	.
cord-015021-pol2qm74	159	1	Hence	hence	RB
cord-015021-pol2qm74	159	2	,	,	,
cord-015021-pol2qm74	159	3	it	-PRON-	PRP
cord-015021-pol2qm74	159	4	was	be	VBD
cord-015021-pol2qm74	159	5	concluded	conclude	VBN
cord-015021-pol2qm74	159	6	,	,	,
cord-015021-pol2qm74	159	7	that	that	DT
cord-015021-pol2qm74	159	8	rec	rec	NNP
cord-015021-pol2qm74	159	9	.	.	.
cord-015021-pol2qm74	160	1	Hirudin	Hirudin	NNP
cord-015021-pol2qm74	160	2	by	by	IN
cord-015021-pol2qm74	160	3	inkihiting	inkihite	VBG
cord-015021-pol2qm74	160	4	thrombin	thrombin	NN
cord-015021-pol2qm74	160	5	could	could	MD
cord-015021-pol2qm74	160	6	be	be	VB
cord-015021-pol2qm74	160	7	effective	effective	JJ
cord-015021-pol2qm74	160	8	in	in	IN
cord-015021-pol2qm74	160	9	the	the	DT
cord-015021-pol2qm74	160	10	prevention	prevention	NN
cord-015021-pol2qm74	160	11	of	of	IN
cord-015021-pol2qm74	160	12	coagulation	coagulation	NN
cord-015021-pol2qm74	160	13	disorders	disorder	NNS
cord-015021-pol2qm74	160	14	including	include	VBG
cord-015021-pol2qm74	160	15	disseminated	disseminate	VBN
cord-015021-pol2qm74	160	16	intravascular	intravascular	JJ
cord-015021-pol2qm74	160	17	clotting	clotting	NN
cord-015021-pol2qm74	160	18	(	(	-LRB-
cord-015021-pol2qm74	160	19	DIC	DIC	NNP
cord-015021-pol2qm74	160	20	)	)	-RRB-
cord-015021-pol2qm74	160	21	induced	induce	VBN
cord-015021-pol2qm74	160	22	by	by	IN
cord-015021-pol2qm74	160	23	a	a	DT
cord-015021-pol2qm74	160	24	septic	septic	JJ
cord-015021-pol2qm74	160	25	disease	disease	NN
cord-015021-pol2qm74	160	26	.	.	.
cord-015021-pol2qm74	161	1	Research	research	NN
cord-015021-pol2qm74	161	2	Laboratories	Laboratories	NNPS
cord-015021-pol2qm74	161	3	of	of	IN
cord-015021-pol2qm74	161	4	Behringwerke	Behringwerke	NNP
cord-015021-pol2qm74	161	5	AG	AG	NNP
cord-015021-pol2qm74	161	6	,	,	,
cord-015021-pol2qm74	161	7	35001	35001	CD
cord-015021-pol2qm74	161	8	Marburg	Marburg	NNP
cord-015021-pol2qm74	161	9	,	,	,
cord-015021-pol2qm74	161	10	Germany	Germany	NNP
cord-015021-pol2qm74	161	11	$	$	$
cord-015021-pol2qm74	161	12	3	3	CD
cord-015021-pol2qm74	161	13	Novel	Novel	NNP
cord-015021-pol2qm74	161	14	Protease	Protease	NNP
cord-015021-pol2qm74	161	15	Inhibitory	Inhibitory	NNP
cord-015021-pol2qm74	161	16	Activities	Activities	NNPS
cord-015021-pol2qm74	161	17	of	of	IN
cord-015021-pol2qm74	161	18	the	the	DT
cord-015021-pol2qm74	161	19	Second	Second	NNP
cord-015021-pol2qm74	161	20	Domain	Domain	NNP
cord-015021-pol2qm74	161	21	of	of	IN
cord-015021-pol2qm74	161	22	Urinary	urinary	JJ
cord-015021-pol2qm74	161	23	Trypsin	Trypsin	NNP
cord-015021-pol2qm74	161	24	Inhibitor	Inhibitor	NNP
cord-015021-pol2qm74	161	25	(	(	-LRB-
cord-015021-pol2qm74	161	26	R-020	r-020	NN
cord-015021-pol2qm74	161	27	)	)	-RRB-
cord-015021-pol2qm74	161	28	and	and	CC
cord-015021-pol2qm74	161	29	its	-PRON-	PRP$
cord-015021-pol2qm74	161	30	Effect	effect	NN
cord-015021-pol2qm74	161	31	on	on	IN
cord-015021-pol2qm74	161	32	SepNs	sepns	NN
cord-015021-pol2qm74	161	33	-	-	HYPH
cord-015021-pol2qm74	161	34	lnduced	lnduce	VBN
cord-015021-pol2qm74	161	35	Organ	Organ	NNP
cord-015021-pol2qm74	161	36	Injury	Injury	NNP
cord-015021-pol2qm74	161	37	in	in	IN
cord-015021-pol2qm74	161	38	Rat	Rat	NNP
cord-015021-pol2qm74	161	39	Atsuo	Atsuo	NNP
cord-015021-pol2qm74	161	40	Murata	Murata	NNP
cord-015021-pol2qm74	161	41	1	1	CD
cord-015021-pol2qm74	161	42	,	,	,
cord-015021-pol2qm74	161	43	Hitoshi	Hitoshi	NNP
cord-015021-pol2qm74	161	44	Toda	Toda	NNP
cord-015021-pol2qm74	161	45	1	1	CD
cord-015021-pol2qm74	161	46	,	,	,
cord-015021-pol2qm74	162	1	Ken'ichi	Ken'ichi	NNP
cord-015021-pol2qm74	162	2	Uda	Uda	NNP
cord-015021-pol2qm74	162	3	1	1	CD
cord-015021-pol2qm74	162	4	,	,	,
cord-015021-pol2qm74	162	5	Hidewaki	Hidewaki	NNP
cord-015021-pol2qm74	162	6	Nakagawa	Nakagawa	NNP
cord-015021-pol2qm74	162	7	1	1	CD
cord-015021-pol2qm74	162	8	,	,	,
cord-015021-pol2qm74	162	9	Takesada	Takesada	NNP
cord-015021-pol2qm74	162	10	Mori	Mori	NNP
cord-015021-pol2qm74	162	11	1	1	CD
cord-015021-pol2qm74	162	12	,	,	,
cord-015021-pol2qm74	162	13	Hideaki	Hideaki	NNP
cord-015021-pol2qm74	162	14	Morishita	Morishita	NNP
cord-015021-pol2qm74	162	15	2	2	CD
cord-015021-pol2qm74	162	16	,	,	,
cord-015021-pol2qm74	162	17	Tom	Tom	NNP
cord-015021-pol2qm74	162	18	Yamakawa	Yamakawa	NNP
cord-015021-pol2qm74	162	19	2	2	CD
cord-015021-pol2qm74	162	20	,	,	,
cord-015021-pol2qm74	162	21	Jiro	Jiro	NNP
cord-015021-pol2qm74	162	22	Hirese	Hirese	NNP
cord-015021-pol2qm74	162	23	2	2	CD
cord-015021-pol2qm74	162	24	,	,	,
cord-015021-pol2qm74	162	25	Atsushi	Atsushi	NNP
cord-015021-pol2qm74	162	26	Ni~	Ni~	NNP
cord-015021-pol2qm74	162	27	2	2	CD
cord-015021-pol2qm74	162	28	,	,	,
cord-015021-pol2qm74	162	29	Nariaki	Nariaki	NNP
cord-015021-pol2qm74	162	30	Matsuura	Matsuura	NNP
cord-015021-pol2qm74	162	31	3	3	CD
cord-015021-pol2qm74	162	32	1Osaka	1Osaka	NNP
cord-015021-pol2qm74	162	33	University	University	NNP
cord-015021-pol2qm74	162	34	Medical	Medical	NNP
cord-015021-pol2qm74	162	35	School	School	NNP
cord-015021-pol2qm74	162	36	,	,	,
cord-015021-pol2qm74	162	37	Osaka	Osaka	NNP
cord-015021-pol2qm74	162	38	,	,	,
cord-015021-pol2qm74	163	1	2Mochida	2mochida	CD
cord-015021-pol2qm74	163	2	Pharmaceutical	Pharmaceutical	NNP
cord-015021-pol2qm74	163	3	Co.	Co.	NNP
cord-015021-pol2qm74	163	4	Ltd.	Ltd.	NNP
cord-015021-pol2qm74	163	5	Tokyo	Tokyo	NNP
cord-015021-pol2qm74	163	6	,	,	,
cord-015021-pol2qm74	163	7	3Wakayama	3Wakayama	NNP
cord-015021-pol2qm74	163	8	Medical	Medical	NNP
cord-015021-pol2qm74	163	9	Schoof	Schoof	NNP
cord-015021-pol2qm74	163	10	,	,	,
cord-015021-pol2qm74	163	11	Wakayama	Wakayama	NNP
cord-015021-pol2qm74	163	12	,	,	,
cord-015021-pol2qm74	163	13	Japan	Japan	NNP
cord-015021-pol2qm74	163	14	Inhibitory	Inhibitory	NNP
cord-015021-pol2qm74	163	15	-	-	HYPH
cord-015021-pol2qm74	163	16	activities	activity	NNS
cord-015021-pol2qm74	163	17	of	of	IN
cord-015021-pol2qm74	163	18	the	the	DT
cord-015021-pol2qm74	163	19	second	second	JJ
cord-015021-pol2qm74	163	20	KuNtz	KuNtz	NNP
cord-015021-pol2qm74	163	21	-	-	HYPH
cord-015021-pol2qm74	163	22	type	type	NN
cord-015021-pol2qm74	163	23	inhibitor	inhibitor	NN
cord-015021-pol2qm74	163	24	domain	domain	NN
cord-015021-pol2qm74	163	25	of	of	IN
cord-015021-pol2qm74	163	26	human	human	JJ
cord-015021-pol2qm74	163	27	urinary	urinary	JJ
cord-015021-pol2qm74	163	28	trypsin	trypsin	NN
cord-015021-pol2qm74	163	29	inhibitor	inhibitor	NN
cord-015021-pol2qm74	163	30	(	(	-LRB-
cord-015021-pol2qm74	163	31	UTI	UTI	NNP
cord-015021-pol2qm74	163	32	)	)	-RRB-
cord-015021-pol2qm74	163	33	and	and	CC
cord-015021-pol2qm74	163	34	its	-PRON-	PRP$
cord-015021-pol2qm74	163	35	effect	effect	NN
cord-015021-pol2qm74	163	36	on	on	IN
cord-015021-pol2qm74	163	37	sepsis	sepsis	NN
cord-015021-pol2qm74	163	38	-	-	HYPH
cord-015021-pol2qm74	163	39	induced	induce	VBN
cord-015021-pol2qm74	163	40	organ	organ	NN
cord-015021-pol2qm74	163	41	injury	injury	NN
cord-015021-pol2qm74	163	42	in	in	IN
cord-015021-pol2qm74	163	43	rat	rat	NN
cord-015021-pol2qm74	163	44	were	be	VBD
cord-015021-pol2qm74	163	45	investigated	investigate	VBN
cord-015021-pol2qm74	163	46	by	by	IN
cord-015021-pol2qm74	163	47	using	use	VBG
cord-015021-pol2qm74	163	48	the	the	DT
cord-015021-pol2qm74	163	49	recombinant	recombinant	JJ
cord-015021-pol2qm74	163	50	protein	protein	NN
cord-015021-pol2qm74	163	51	.	.	.
cord-015021-pol2qm74	164	1	UTI	UTI	NNP
cord-015021-pol2qm74	164	2	is	be	VBZ
cord-015021-pol2qm74	164	3	a	a	DT
cord-015021-pol2qm74	164	4	glycoprotein	glycoprotein	NN
cord-015021-pol2qm74	164	5	with	with	IN
cord-015021-pol2qm74	164	6	a	a	DT
cord-015021-pol2qm74	164	7	structure	structure	NN
cord-015021-pol2qm74	164	8	in	in	IN
cord-015021-pol2qm74	164	9	which	which	WDT
cord-015021-pol2qm74	164	10	2	2	CD
cord-015021-pol2qm74	164	11	Kunitz	Kunitz	NNP
cord-015021-pol2qm74	164	12	-	-	HYPH
cord-015021-pol2qm74	164	13	type	type	NN
cord-015021-pol2qm74	164	14	inhibitor	inhibitor	NN
cord-015021-pol2qm74	164	15	domains	domain	NNS
cord-015021-pol2qm74	164	16	are	be	VBP
cord-015021-pol2qm74	164	17	linked	link	VBN
cord-015021-pol2qm74	164	18	in	in	IN
cord-015021-pol2qm74	164	19	a	a	DT
cord-015021-pol2qm74	164	20	row	row	NN
cord-015021-pol2qm74	164	21	.	.	.
cord-015021-pol2qm74	165	1	We	-PRON-	PRP
cord-015021-pol2qm74	165	2	isolated	isolate	VBD
cord-015021-pol2qm74	165	3	the	the	DT
cord-015021-pol2qm74	165	4	gene	gene	NN
cord-015021-pol2qm74	165	5	encoding	encode	VBG
cord-015021-pol2qm74	165	6	the	the	DT
cord-015021-pol2qm74	165	7	second	second	JJ
cord-015021-pol2qm74	165	8	Kunitz	Kunitz	NNP
cord-015021-pol2qm74	165	9	-	-	HYPH
cord-015021-pol2qm74	165	10	type	type	NN
cord-015021-pol2qm74	165	11	inhibitor	inhibitor	NN
cord-015021-pol2qm74	165	12	domain	domain	NN
cord-015021-pol2qm74	165	13	of	of	IN
cord-015021-pol2qm74	165	14	UTI	UTI	NNP
cord-015021-pol2qm74	165	15	,	,	,
cord-015021-pol2qm74	165	16	and	and	CC
cord-015021-pol2qm74	165	17	then	then	RB
cord-015021-pol2qm74	165	18	constructed	construct	VBN
cord-015021-pol2qm74	165	19	expression	expression	NN
cord-015021-pol2qm74	165	20	plasmids	plasmid	NNS
cord-015021-pol2qm74	165	21	by	by	IN
cord-015021-pol2qm74	165	22	ligating	ligate	VBG
cord-015021-pol2qm74	165	23	it	-PRON-	PRP
cord-015021-pol2qm74	165	24	to	to	IN
cord-015021-pol2qm74	165	25	the	the	DT
cord-015021-pol2qm74	165	26	E.	E.	NNP
cord-015021-pol2qm74	165	27	coli	coli	NNS
cord-015021-pol2qm74	165	28	PhoA	PhoA	NNP
cord-015021-pol2qm74	165	29	signal	signal	NN
cord-015021-pol2qm74	165	30	peptide	peptide	NN
cord-015021-pol2qm74	165	31	gene	gene	NN
cord-015021-pol2qm74	165	32	.	.	.
cord-015021-pol2qm74	166	1	These	these	DT
cord-015021-pol2qm74	166	2	plasmids	plasmid	NNS
cord-015021-pol2qm74	166	3	expressed	express	VBD
cord-015021-pol2qm74	166	4	the	the	DT
cord-015021-pol2qm74	166	5	second	second	JJ
cord-015021-pol2qm74	166	6	domain	domain	NN
cord-015021-pol2qm74	166	7	in	in	IN
cord-015021-pol2qm74	166	8	E.	E.	NNP
cord-015021-pol2qm74	166	9	coil	coil	NN
cord-015021-pol2qm74	166	10	strain	strain	VB
cord-015021-pol2qm74	166	11	JE5505	je5505	NN
cord-015021-pol2qm74	166	12	which	which	WDT
cord-015021-pol2qm74	166	13	lacks	lack	VBZ
cord-015021-pol2qm74	166	14	the	the	DT
cord-015021-pol2qm74	166	15	membrane	membrane	NN
cord-015021-pol2qm74	166	16	lipoprotein	lipoprotein	NN
cord-015021-pol2qm74	166	17	.	.	.
cord-015021-pol2qm74	167	1	The	the	DT
cord-015021-pol2qm74	167	2	recombinant	recombinant	JJ
cord-015021-pol2qm74	167	3	second	second	JJ
cord-015021-pol2qm74	167	4	domain	domain	NN
cord-015021-pol2qm74	167	5	(	(	-LRB-
cord-015021-pol2qm74	167	6	R-020	r-020	NN
cord-015021-pol2qm74	167	7	)	)	-RRB-
cord-015021-pol2qm74	167	8	inNb[ted	innb[ted	CD
cord-015021-pol2qm74	167	9	trypsin	trypsin	NN
cord-015021-pol2qm74	167	10	,	,	,
cord-015021-pol2qm74	167	11	plasmin	plasmin	NN
cord-015021-pol2qm74	167	12	,	,	,
cord-015021-pol2qm74	167	13	neutrophil	neutrophil	NN
cord-015021-pol2qm74	167	14	elastase	elastase	NN
cord-015021-pol2qm74	167	15	and	and	CC
cord-015021-pol2qm74	167	16	chymotrypsin	chymotrypsin	NNP
cord-015021-pol2qm74	167	17	.	.	.
cord-015021-pol2qm74	168	1	In	in	IN
cord-015021-pol2qm74	168	2	addition	addition	NN
cord-015021-pol2qm74	168	3	it	-PRON-	PRP
cord-015021-pol2qm74	168	4	inhibited	inhibit	VBD
cord-015021-pol2qm74	168	5	blood	blood	NN
cord-015021-pol2qm74	168	6	coagulation	coagulation	NN
cord-015021-pol2qm74	168	7	factor	factor	NN
cord-015021-pol2qm74	169	1	Xa	Xa	NNP
cord-015021-pol2qm74	169	2	and	and	CC
cord-015021-pol2qm74	169	3	plasma	plasma	NNP
cord-015021-pol2qm74	169	4	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	169	5	in	in	IN
cord-015021-pol2qm74	169	6	a	a	DT
cord-015021-pol2qm74	169	7	concentration	concentration	NN
cord-015021-pol2qm74	169	8	dependent	dependent	JJ
cord-015021-pol2qm74	169	9	and	and	CC
cord-015021-pol2qm74	169	10	competitive	competitive	JJ
cord-015021-pol2qm74	169	11	manner	manner	NN
cord-015021-pol2qm74	169	12	.	.	.
cord-015021-pol2qm74	170	1	The	the	DT
cord-015021-pol2qm74	170	2	in	in	IN
cord-015021-pol2qm74	170	3	vivo	vivo	NN
cord-015021-pol2qm74	170	4	effect	effect	NN
cord-015021-pol2qm74	170	5	of	of	IN
cord-015021-pol2qm74	170	6	the	the	DT
cord-015021-pol2qm74	170	7	recombinant	recombinant	JJ
cord-015021-pol2qm74	170	8	R-020	r-020	NN
cord-015021-pol2qm74	170	9	was	be	VBD
cord-015021-pol2qm74	170	10	investigated	investigate	VBN
cord-015021-pol2qm74	170	11	in	in	IN
cord-015021-pol2qm74	170	12	a	a	DT
cord-015021-pol2qm74	170	13	rat	rat	NN
cord-015021-pol2qm74	170	14	model	model	NN
cord-015021-pol2qm74	170	15	of	of	IN
cord-015021-pol2qm74	170	16	septic	septic	JJ
cord-015021-pol2qm74	170	17	shock	shock	NN
cord-015021-pol2qm74	170	18	induced	induce	VBN
cord-015021-pol2qm74	170	19	by	by	IN
cord-015021-pol2qm74	170	20	cecal	cecal	JJ
cord-015021-pol2qm74	170	21	ligation	ligation	NN
cord-015021-pol2qm74	170	22	and	and	CC
cord-015021-pol2qm74	170	23	puncture	puncture	NN
cord-015021-pol2qm74	170	24	.	.	.
cord-015021-pol2qm74	171	1	The	the	DT
cord-015021-pol2qm74	171	2	administration	administration	NN
cord-015021-pol2qm74	171	3	of	of	IN
cord-015021-pol2qm74	171	4	R-020	r-020	NN
cord-015021-pol2qm74	171	5	significantly	significantly	RB
cord-015021-pol2qm74	171	6	improved	improve	VBD
cord-015021-pol2qm74	171	7	the	the	DT
cord-015021-pol2qm74	171	8	survival	survival	NN
cord-015021-pol2qm74	171	9	rate	rate	NN
cord-015021-pol2qm74	171	10	of	of	IN
cord-015021-pol2qm74	171	11	the	the	DT
cord-015021-pol2qm74	171	12	rats	rat	NNS
cord-015021-pol2qm74	171	13	and	and	CC
cord-015021-pol2qm74	171	14	attenuated	attenuate	VBD
cord-015021-pol2qm74	171	15	the	the	DT
cord-015021-pol2qm74	171	16	pathological	pathological	JJ
cord-015021-pol2qm74	171	17	changes	change	NNS
cord-015021-pol2qm74	171	18	of	of	IN
cord-015021-pol2qm74	171	19	lung	lung	NN
cord-015021-pol2qm74	171	20	and	and	CC
cord-015021-pol2qm74	171	21	iiver	iiver	NNP
cord-015021-pol2qm74	171	22	.	.	.
cord-015021-pol2qm74	172	1	We	-PRON-	PRP
cord-015021-pol2qm74	172	2	found	find	VBD
cord-015021-pol2qm74	172	3	out	out	RP
cord-015021-pol2qm74	172	4	the	the	DT
cord-015021-pol2qm74	172	5	novel	novel	JJ
cord-015021-pol2qm74	172	6	protease	protease	NN
cord-015021-pol2qm74	172	7	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	172	8	activities	activity	NNS
cord-015021-pol2qm74	172	9	of	of	IN
cord-015021-pol2qm74	172	10	the	the	DT
cord-015021-pol2qm74	172	11	second	second	JJ
cord-015021-pol2qm74	172	12	domain	domain	NN
cord-015021-pol2qm74	172	13	of	of	IN
cord-015021-pol2qm74	172	14	UTI	UTI	NNP
cord-015021-pol2qm74	172	15	and	and	CC
cord-015021-pol2qm74	172	16	its	-PRON-	PRP$
cord-015021-pol2qm74	172	17	protective	protective	JJ
cord-015021-pol2qm74	172	18	effects	effect	NNS
cord-015021-pol2qm74	172	19	on	on	IN
cord-015021-pol2qm74	172	20	sepsis	sepsis	NN
cord-015021-pol2qm74	172	21	-	-	HYPH
cord-015021-pol2qm74	172	22	induced	induce	VBN
cord-015021-pol2qm74	172	23	organ	organ	NN
cord-015021-pol2qm74	172	24	injury	injury	NN
cord-015021-pol2qm74	172	25	.	.	.
cord-015021-pol2qm74	173	1	Macrophages	macrophage	NNS
cord-015021-pol2qm74	173	2	are	be	VBP
cord-015021-pol2qm74	173	3	known	know	VBN
cord-015021-pol2qm74	173	4	to	to	TO
cord-015021-pol2qm74	173	5	secrete	secrete	VB
cord-015021-pol2qm74	173	6	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	173	7	proteinases	proteinase	NNS
cord-015021-pol2qm74	173	8	,	,	,
cord-015021-pol2qm74	173	9	mainly	mainly	RB
cord-015021-pol2qm74	173	10	cathepsin	cathepsin	NN
cord-015021-pol2qm74	173	11	B	b	NN
cord-015021-pol2qm74	173	12	and	and	CC
cord-015021-pol2qm74	173	13	cathepsin	cathepsin	NN
cord-015021-pol2qm74	173	14	L	l	NN
cord-015021-pol2qm74	173	15	,	,	,
cord-015021-pol2qm74	173	16	and	and	CC
cord-015021-pol2qm74	173	17	also	also	RB
cord-015021-pol2qm74	173	18	~-proteinase	~-proteinase	NFP
cord-015021-pol2qm74	174	1	inhibitor	inhibitor	NN
cord-015021-pol2qm74	174	2	(	(	-LRB-
cord-015021-pol2qm74	174	3	PI),related	pi),relate	VBN
cord-015021-pol2qm74	174	4	to	to	IN
cord-015021-pol2qm74	174	5	acute	acute	JJ
cord-015021-pol2qm74	174	6	phase	phase	NN
cord-015021-pol2qm74	174	7	proteins	protein	NNS
cord-015021-pol2qm74	174	8	.	.	.
cord-015021-pol2qm74	175	1	Disturbances	disturbance	NNS
cord-015021-pol2qm74	175	2	of	of	IN
cord-015021-pol2qm74	175	3	proteinases/	proteinases/	CD
cord-015021-pol2qm74	175	4	proteinase	proteinase	NN
cord-015021-pol2qm74	175	5	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	175	6	correlates	correlate	VBZ
cord-015021-pol2qm74	175	7	with	with	IN
cord-015021-pol2qm74	175	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	175	9	process	process	NN
cord-015021-pol2qm74	175	10	,	,	,
cord-015021-pol2qm74	175	11	leading	lead	VBG
cord-015021-pol2qm74	175	12	sometimes	sometimes	RB
cord-015021-pol2qm74	175	13	to	to	TO
cord-015021-pol2qm74	175	14	noncontrol	noncontrol	VB
cord-015021-pol2qm74	175	15	"	"	``
cord-015021-pol2qm74	175	16	pathGlogical	pathglogical	JJ
cord-015021-pol2qm74	175	17	"	"	''
cord-015021-pol2qm74	175	18	proteolysis	proteolysis	NN
cord-015021-pol2qm74	176	1	(	(	-LRB-
cord-015021-pol2qm74	176	2	Jochum	Jochum	NNP
cord-015021-pol2qm74	176	3	et	et	FW
cord-015021-pol2qm74	176	4	ai	ai	NNP
cord-015021-pol2qm74	176	5	.	.	.
cord-015021-pol2qm74	176	6	,1990	,1990	,
cord-015021-pol2qm74	176	7	)	)	-RRB-
cord-015021-pol2qm74	176	8	.	.	.
cord-015021-pol2qm74	177	1	The	the	DT
cord-015021-pol2qm74	177	2	cathepsin	cathepsin	NN
cord-015021-pol2qm74	177	3	L	l	NN
cord-015021-pol2qm74	177	4	-	-	HYPH
cord-015021-pol2qm74	177	5	like	like	JJ
cord-015021-pol2qm74	177	6	and	and	CC
cord-015021-pol2qm74	177	7	cathepsin	cathepsin	NN
cord-015021-pol2qm74	177	8	B	b	NN
cord-015021-pol2qm74	177	9	-	-	HYPH
cord-015021-pol2qm74	177	10	like	like	JJ
cord-015021-pol2qm74	177	11	activity	activity	NN
cord-015021-pol2qm74	177	12	were	be	VBD
cord-015021-pol2qm74	177	13	measured	measure	VBN
cord-015021-pol2qm74	177	14	in	in	IN
cord-015021-pol2qm74	177	15	serum	serum	NN
cord-015021-pol2qm74	177	16	of	of	IN
cord-015021-pol2qm74	177	17	42	42	CD
cord-015021-pol2qm74	177	18	patients	patient	NNS
cord-015021-pol2qm74	177	19	with	with	IN
cord-015021-pol2qm74	177	20	chronic	chronic	JJ
cord-015021-pol2qm74	177	21	bronchitis	bronchitis	NN
cord-015021-pol2qm74	177	22	(	(	-LRB-
cord-015021-pol2qm74	177	23	14	14	CD
cord-015021-pol2qm74	177	24	-with	-with	CD
cord-015021-pol2qm74	177	25	obstructive	obstructive	JJ
cord-015021-pol2qm74	177	26	,	,	,
cord-015021-pol2qm74	177	27	28	28	CD
cord-015021-pol2qm74	177	28	-with	-with	CD
cord-015021-pol2qm74	177	29	nonobstructive	nonobstructive	JJ
cord-015021-pol2qm74	177	30	bronchitis),acute	bronchitis),acute	NNP
cord-015021-pol2qm74	177	31	bronchitis	bronchitis	NN
cord-015021-pol2qm74	177	32	(	(	-LRB-
cord-015021-pol2qm74	177	33	15	15	CD
cord-015021-pol2qm74	177	34	)	)	-RRB-
cord-015021-pol2qm74	177	35	and	and	CC
cord-015021-pol2qm74	177	36	35	35	CD
cord-015021-pol2qm74	177	37	healthy	healthy	JJ
cord-015021-pol2qm74	177	38	persons	person	NNS
cord-015021-pol2qm74	177	39	.	.	.
cord-015021-pol2qm74	178	1	Simultaneously	simultaneously	RB
cord-015021-pol2qm74	178	2	the	the	DT
cord-015021-pol2qm74	178	3	level	level	NN
cord-015021-pol2qm74	178	4	of	of	IN
cord-015021-pol2qm74	178	5	~	~	NFP
cord-015021-pol2qm74	178	6	PI	PI	NNP
cord-015021-pol2qm74	178	7	was	be	VBD
cord-015021-pol2qm74	178	8	determined	determine	VBN
cord-015021-pol2qm74	178	9	in	in	IN
cord-015021-pol2qm74	178	10	the	the	DT
cord-015021-pol2qm74	178	11	same	same	JJ
cord-015021-pol2qm74	178	12	groups	group	NNS
cord-015021-pol2qm74	178	13	.	.	.
cord-015021-pol2qm74	179	1	Cysteine	cysteine	NN
cord-015021-pol2qm74	179	2	proteinases	proteinase	NNS
cord-015021-pol2qm74	179	3	were	be	VBD
cord-015021-pol2qm74	179	4	measured	measure	VBN
cord-015021-pol2qm74	179	5	with	with	IN
cord-015021-pol2qm74	179	6	help	help	NN
cord-015021-pol2qm74	179	7	of	of	IN
cord-015021-pol2qm74	179	8	fluorogenic	fluorogenic	JJ
cord-015021-pol2qm74	179	9	substrates	substrate	NNS
cord-015021-pol2qm74	179	10	,	,	,
cord-015021-pol2qm74	179	11	as	as	IN
cord-015021-pol2qm74	179	12	was	be	VBD
cord-015021-pol2qm74	179	13	presented	present	VBN
cord-015021-pol2qm74	179	14	earlier	early	RBR
cord-015021-pol2qm74	180	1	(	(	-LRB-
cord-015021-pol2qm74	180	2	Korolenko	Korolenko	NNP
cord-015021-pol2qm74	180	3	et	et	NNP
cord-015021-pol2qm74	180	4	ai	ai	NNP
cord-015021-pol2qm74	180	5	.	.	.
cord-015021-pol2qm74	180	6	,1991	,1991	,
cord-015021-pol2qm74	180	7	)	)	-RRB-
cord-015021-pol2qm74	180	8	,	,	.
cord-015021-pol2qm74	181	1	~PI	~PI	.
cord-015021-pol2qm74	182	1	with	with	IN
cord-015021-pol2qm74	182	2	help	help	NN
cord-015021-pol2qm74	182	3	of	of	IN
cord-015021-pol2qm74	182	4	immune	immune	JJ
cord-015021-pol2qm74	182	5	enzyme	enzyme	NN
cord-015021-pol2qm74	182	6	method	method	NN
cord-015021-pol2qm74	182	7	.	.	.
cord-015021-pol2qm74	183	1	It	-PRON-	PRP
cord-015021-pol2qm74	183	2	was	be	VBD
cord-015021-pol2qm74	183	3	shown	show	VBN
cord-015021-pol2qm74	183	4	increase	increase	NN
cord-015021-pol2qm74	183	5	of	of	IN
cord-015021-pol2qm74	183	6	cathepsin	cathepsin	NN
cord-015021-pol2qm74	183	7	L	l	NN
cord-015021-pol2qm74	183	8	-	-	HYPH
cord-015021-pol2qm74	183	9	like	like	JJ
cord-015021-pol2qm74	183	10	and	and	CC
cord-015021-pol2qm74	183	11	cathepsin	cathepsin	NN
cord-015021-pol2qm74	183	12	B	b	NN
cord-015021-pol2qm74	183	13	-	-	HYPH
cord-015021-pol2qm74	183	14	like	like	JJ
cord-015021-pol2qm74	183	15	activities	activity	NNS
cord-015021-pol2qm74	183	16	during	during	IN
cord-015021-pol2qm74	183	17	aggravation	aggravation	NN
cord-015021-pol2qm74	183	18	of	of	IN
cord-015021-pol2qm74	183	19	chronic	chronic	JJ
cord-015021-pol2qm74	183	20	bronchitis	bronchitis	NN
cord-015021-pol2qm74	183	21	comparatively	comparatively	RB
cord-015021-pol2qm74	183	22	to	to	IN
cord-015021-pol2qm74	183	23	the	the	DT
cord-015021-pol2qm74	183	24	controls	control	NNS
cord-015021-pol2qm74	183	25	(	(	-LRB-
cord-015021-pol2qm74	183	26	2	2	CD
cord-015021-pol2qm74	183	27	-	-	SYM
cord-015021-pol2qm74	183	28	4	4	CD
cord-015021-pol2qm74	183	29	fold	fold	NN
cord-015021-pol2qm74	183	30	)	)	-RRB-
cord-015021-pol2qm74	184	1	.After	.After	NFP
cord-015021-pol2qm74	184	2	treatment	treatment	NN
cord-015021-pol2qm74	184	3	there	there	EX
cord-015021-pol2qm74	184	4	was	be	VBD
cord-015021-pol2qm74	184	5	a	a	DT
cord-015021-pol2qm74	184	6	tendency	tendency	NN
cord-015021-pol2qm74	184	7	to	to	IN
cord-015021-pol2qm74	184	8	normalization	normalization	NN
cord-015021-pol2qm74	184	9	of	of	IN
cord-015021-pol2qm74	184	10	indices	index	NNS
cord-015021-pol2qm74	184	11	,	,	,
cord-015021-pol2qm74	184	12	but	but	CC
cord-015021-pol2qm74	184	13	the	the	DT
cord-015021-pol2qm74	184	14	increase	increase	NN
cord-015021-pol2qm74	184	15	was	be	VBD
cord-015021-pol2qm74	184	16	about	about	RB
cord-015021-pol2qm74	184	17	30	30	CD
cord-015021-pol2qm74	184	18	-	-	SYM
cord-015021-pol2qm74	184	19	40	40	CD
cord-015021-pol2qm74	184	20	%	%	NN
cord-015021-pol2qm74	184	21	more	more	JJR
cord-015021-pol2qm74	184	22	than	than	IN
cord-015021-pol2qm74	184	23	the	the	DT
cord-015021-pol2qm74	184	24	control	control	NN
cord-015021-pol2qm74	184	25	values.~PI	values.~pi	IN
cord-015021-pol2qm74	184	26	level	level	NN
cord-015021-pol2qm74	184	27	in	in	IN
cord-015021-pol2qm74	184	28	this	this	DT
cord-015021-pol2qm74	184	29	group	group	NN
cord-015021-pol2qm74	184	30	was	be	VBD
cord-015021-pol2qm74	184	31	also	also	RB
cord-015021-pol2qm74	184	32	increased	increase	VBN
cord-015021-pol2qm74	185	1	(	(	-LRB-
cord-015021-pol2qm74	185	2	two	two	CD
cord-015021-pol2qm74	185	3	-	-	HYPH
cord-015021-pol2qm74	185	4	fold),in	fold),in	NN
cord-015021-pol2qm74	185	5	patients	patient	NNS
cord-015021-pol2qm74	185	6	with	with	IN
cord-015021-pol2qm74	185	7	acute	acute	JJ
cord-015021-pol2qm74	185	8	bronchitis	bronchitis	NN
cord-015021-pol2qm74	185	9	-2	-2	NN
cord-015021-pol2qm74	185	10	-	-	:
cord-015021-pol2qm74	185	11	4-times	4-times	CD
cord-015021-pol2qm74	185	12	more	more	RBR
cord-015021-pol2qm74	185	13	comparatively	comparatively	RB
cord-015021-pol2qm74	185	14	to	to	IN
cord-015021-pol2qm74	185	15	the	the	DT
cord-015021-pol2qm74	185	16	control	control	NN
cord-015021-pol2qm74	185	17	.	.	.
cord-015021-pol2qm74	186	1	It	-PRON-	PRP
cord-015021-pol2qm74	186	2	is	be	VBZ
cord-015021-pol2qm74	186	3	possible	possible	JJ
cord-015021-pol2qm74	186	4	to	to	TO
cord-015021-pol2qm74	186	5	conclude	conclude	VB
cord-015021-pol2qm74	186	6	that	that	IN
cord-015021-pol2qm74	186	7	chronic	chronic	JJ
cord-015021-pol2qm74	186	8	bronchitis	bronchitis	NN
cord-015021-pol2qm74	186	9	induced	induce	VBN
cord-015021-pol2qm74	186	10	increased	increase	VBD
cord-015021-pol2qm74	186	11	secretion	secretion	NN
cord-015021-pol2qm74	186	12	both	both	DT
cord-015021-pol2qm74	186	13	cysteine	cysteine	NN
cord-015021-pol2qm74	186	14	proteinases	proteinase	NNS
cord-015021-pol2qm74	186	15	and	and	CC
cord-015021-pol2qm74	186	16	d{PI	d{pi	NN
cord-015021-pol2qm74	186	17	into	into	IN
cord-015021-pol2qm74	186	18	blood	blood	NN
cord-015021-pol2qm74	186	19	.	.	.
cord-015021-pol2qm74	187	1	Some	some	DT
cord-015021-pol2qm74	187	2	peculiarities	peculiarity	NNS
cord-015021-pol2qm74	187	3	of	of	IN
cord-015021-pol2qm74	187	4	ratio	ratio	NN
cord-015021-pol2qm74	187	5	were	be	VBD
cord-015021-pol2qm74	187	6	noted	note	VBN
cord-015021-pol2qm74	187	7	in	in	IN
cord-015021-pol2qm74	187	8	patients	patient	NNS
cord-015021-pol2qm74	187	9	with	with	IN
cord-015021-pol2qm74	187	10	emphysema	emphysema	NN
cord-015021-pol2qm74	187	11	.	.	.
cord-015021-pol2qm74	188	1	Endotoxins	endotoxin	NNS
cord-015021-pol2qm74	188	2	are	be	VBP
cord-015021-pol2qm74	188	3	microbial	microbial	JJ
cord-015021-pol2qm74	188	4	products	product	NNS
cord-015021-pol2qm74	188	5	derived	derive	VBN
cord-015021-pol2qm74	188	6	from	from	IN
cord-015021-pol2qm74	188	7	the	the	DT
cord-015021-pol2qm74	188	8	outer	outer	JJ
cord-015021-pol2qm74	188	9	cell	cell	NN
cord-015021-pol2qm74	188	10	membrane	membrane	NN
cord-015021-pol2qm74	188	11	of	of	IN
cord-015021-pol2qm74	188	12	Gram	Gram	NNP
cord-015021-pol2qm74	188	13	negative	negative	JJ
cord-015021-pol2qm74	188	14	bacteria	bacteria	NNS
cord-015021-pol2qm74	188	15	.	.	.
cord-015021-pol2qm74	189	1	The	the	DT
cord-015021-pol2qm74	189	2	active	active	JJ
cord-015021-pol2qm74	189	3	component	component	NN
cord-015021-pol2qm74	189	4	of	of	IN
cord-015021-pol2qm74	189	5	endotoxin	endotoxin	NN
cord-015021-pol2qm74	189	6	is	be	VBZ
cord-015021-pol2qm74	189	7	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	189	8	(	(	-LRB-
cord-015021-pol2qm74	189	9	LPS	LPS	NNP
cord-015021-pol2qm74	189	10	)	)	-RRB-
cord-015021-pol2qm74	189	11	,	,	,
cord-015021-pol2qm74	189	12	a	a	DT
cord-015021-pol2qm74	189	13	complex	complex	JJ
cord-015021-pol2qm74	189	14	macromolecule	macromolecule	NN
cord-015021-pol2qm74	189	15	consisting	consist	VBG
cord-015021-pol2qm74	189	16	of	of	IN
cord-015021-pol2qm74	189	17	polysaccharide	polysaccharide	NN
cord-015021-pol2qm74	189	18	covalently	covalently	RB
cord-015021-pol2qm74	189	19	bound	bind	VBN
cord-015021-pol2qm74	189	20	to	to	IN
cord-015021-pol2qm74	189	21	a	a	DT
cord-015021-pol2qm74	189	22	unique	unique	JJ
cord-015021-pol2qm74	189	23	lipid	lipid	NN
cord-015021-pol2qm74	189	24	,	,	,
cord-015021-pol2qm74	189	25	termed	term	VBD
cord-015021-pol2qm74	189	26	lipid	lipid	NN
cord-015021-pol2qm74	189	27	A.	a.	NN
cord-015021-pol2qm74	189	28	Now	now	RB
cord-015021-pol2qm74	189	29	recognized	recognize	VBN
cord-015021-pol2qm74	189	30	to	to	TO
cord-015021-pol2qm74	189	31	embody	embody	VB
cord-015021-pol2qm74	189	32	the	the	DT
cord-015021-pol2qm74	189	33	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	189	34	principle	principle	NN
cord-015021-pol2qm74	189	35	of	of	IN
cord-015021-pol2qm74	189	36	LPS	LPS	NNP
cord-015021-pol2qm74	189	37	,	,	,
cord-015021-pol2qm74	189	38	lipid	lipid	NN
cord-015021-pol2qm74	189	39	A	a	NN
cord-015021-pol2qm74	189	40	consists	consists	NN
cord-015021-pol2qm74	189	41	of	of	IN
cord-015021-pol2qm74	189	42	a/31	a/31	NNP
cord-015021-pol2qm74	189	43	-	-	HYPH
cord-015021-pol2qm74	189	44	6	6	CD
cord-015021-pol2qm74	189	45	diglucosamine	diglucosamine	NN
cord-015021-pol2qm74	189	46	backbone	backbone	NN
cord-015021-pol2qm74	189	47	,	,	,
cord-015021-pol2qm74	189	48	both	both	CC
cord-015021-pol2qm74	189	49	ester	ester	NN
cord-015021-pol2qm74	189	50	and	and	CC
cord-015021-pol2qm74	189	51	amide	amide	NN
cord-015021-pol2qm74	189	52	linked	link	VBD
cord-015021-pol2qm74	189	53	fatty	fatty	JJ
cord-015021-pol2qm74	189	54	acids	acid	NNS
cord-015021-pol2qm74	189	55	,	,	,
cord-015021-pol2qm74	189	56	some	some	DT
cord-015021-pol2qm74	189	57	of	of	IN
cord-015021-pol2qm74	189	58	which	which	WDT
cord-015021-pol2qm74	189	59	are	be	VBP
cord-015021-pol2qm74	189	60	acyloxyacylated	acyloxyacylate	VBN
cord-015021-pol2qm74	189	61	,	,	,
cord-015021-pol2qm74	189	62	and	and	CC
cord-015021-pol2qm74	189	63	charged	charge	VBD
cord-015021-pol2qm74	189	64	constituents	constituent	NNS
cord-015021-pol2qm74	189	65	such	such	JJ
cord-015021-pol2qm74	189	66	as	as	IN
cord-015021-pol2qm74	189	67	phosphate	phosphate	NN
cord-015021-pol2qm74	189	68	,	,	,
cord-015021-pol2qm74	189	69	phosphorylethanolamine	phosphorylethanolamine	NN
cord-015021-pol2qm74	189	70	and	and	CC
cord-015021-pol2qm74	189	71	4	4	CD
cord-015021-pol2qm74	189	72	amino	amino	JJ
cord-015021-pol2qm74	189	73	arbinose	arbinose	JJ
cord-015021-pol2qm74	189	74	LPS	lp	NNS
cord-015021-pol2qm74	189	75	,	,	,
cord-015021-pol2qm74	189	76	exerts	exert	VBZ
cord-015021-pol2qm74	189	77	its	-PRON-	PRP$
cord-015021-pol2qm74	189	78	biological	biological	JJ
cord-015021-pol2qm74	189	79	effects	effect	NNS
cord-015021-pol2qm74	189	80	in	in	IN
cord-015021-pol2qm74	189	81	vivo	vivo	NN
cord-015021-pol2qm74	189	82	by	by	IN
cord-015021-pol2qm74	189	83	noncytotoxic	noncytotoxic	NNP
cord-015021-pol2qm74	189	84	interactions	interaction	NNS
cord-015021-pol2qm74	189	85	with	with	IN
cord-015021-pol2qm74	189	86	a	a	DT
cord-015021-pol2qm74	189	87	variety	variety	NN
cord-015021-pol2qm74	189	88	of	of	IN
cord-015021-pol2qm74	189	89	host	host	NN
cord-015021-pol2qm74	189	90	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	189	91	mediator	mediator	NN
cord-015021-pol2qm74	189	92	cells	cell	NNS
cord-015021-pol2qm74	189	93	,	,	,
cord-015021-pol2qm74	189	94	primarily	primarily	RB
cord-015021-pol2qm74	189	95	the	the	DT
cord-015021-pol2qm74	189	96	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	189	97	phagocyte	phagocyte	NNP
cord-015021-pol2qm74	189	98	and	and	CC
cord-015021-pol2qm74	189	99	the	the	DT
cord-015021-pol2qm74	189	100	endothelial	endothelial	JJ
cord-015021-pol2qm74	189	101	cell	cell	NN
cord-015021-pol2qm74	189	102	,	,	,
cord-015021-pol2qm74	189	103	although	although	IN
cord-015021-pol2qm74	189	104	other	other	JJ
cord-015021-pol2qm74	189	105	host	host	NN
cord-015021-pol2qm74	189	106	cells	cell	NNS
cord-015021-pol2qm74	189	107	also	also	RB
cord-015021-pol2qm74	189	108	participate	participate	VBP
cord-015021-pol2qm74	189	109	.	.	.
cord-015021-pol2qm74	190	1	These	these	DT
cord-015021-pol2qm74	190	2	interactions	interaction	NNS
cord-015021-pol2qm74	190	3	are	be	VBP
cord-015021-pol2qm74	190	4	modulated	modulate	VBN
cord-015021-pol2qm74	190	5	by	by	IN
cord-015021-pol2qm74	190	6	LPS	LPS	NNP
cord-015021-pol2qm74	190	7	-	-	HYPH
cord-015021-pol2qm74	190	8	specific	specific	JJ
cord-015021-pol2qm74	190	9	binding	bind	VBG
cord-015021-pol2qm74	190	10	proteins	protein	NNS
cord-015021-pol2qm74	190	11	found	find	VBN
cord-015021-pol2qm74	190	12	in	in	IN
cord-015021-pol2qm74	190	13	plasma	plasma	NN
cord-015021-pol2qm74	190	14	,	,	,
cord-015021-pol2qm74	190	15	including	include	VBG
cord-015021-pol2qm74	190	16	LPS	lps	NN
cord-015021-pol2qm74	190	17	-	-	HYPH
cord-015021-pol2qm74	190	18	binding	bind	VBG
cord-015021-pol2qm74	190	19	protein	protein	NN
cord-015021-pol2qm74	190	20	(	(	-LRB-
cord-015021-pol2qm74	190	21	LBP	LBP	NNP
cord-015021-pol2qm74	190	22	)	)	-RRB-
cord-015021-pol2qm74	190	23	sCD14	scd14	NN
cord-015021-pol2qm74	190	24	and	and	CC
cord-015021-pol2qm74	190	25	perhaps	perhaps	RB
cord-015021-pol2qm74	190	26	other	other	JJ
cord-015021-pol2qm74	190	27	proteins	protein	NNS
cord-015021-pol2qm74	190	28	as	as	RB
cord-015021-pol2qm74	190	29	well	well	RB
cord-015021-pol2qm74	190	30	.	.	.
cord-015021-pol2qm74	191	1	Specific	specific	JJ
cord-015021-pol2qm74	191	2	receptors	receptor	NNS
cord-015021-pol2qm74	191	3	for	for	IN
cord-015021-pol2qm74	191	4	LPS	lp	NNS
cord-015021-pol2qm74	191	5	have	have	VBP
cord-015021-pol2qm74	191	6	been	be	VBN
cord-015021-pol2qm74	191	7	identified	identify	VBN
cord-015021-pol2qm74	191	8	on	on	IN
cord-015021-pol2qm74	191	9	mammalian	mammalian	JJ
cord-015021-pol2qm74	191	10	cells	cell	NNS
cord-015021-pol2qm74	191	11	which	which	WDT
cord-015021-pol2qm74	191	12	mediate	mediate	VBP
cord-015021-pol2qm74	191	13	signal	signal	NN
cord-015021-pol2qm74	191	14	transduction	transduction	NN
cord-015021-pol2qm74	191	15	via	via	IN
cord-015021-pol2qm74	191	16	multiple	multiple	JJ
cord-015021-pol2qm74	191	17	pathways	pathway	NNS
cord-015021-pol2qm74	191	18	.	.	.
cord-015021-pol2qm74	192	1	LPS	LPS	NNP
cord-015021-pol2qm74	192	2	-	-	HYPH
cord-015021-pol2qm74	192	3	activated	activate	VBN
cord-015021-pol2qm74	192	4	host	host	NN
cord-015021-pol2qm74	192	5	cells	cell	NNS
cord-015021-pol2qm74	192	6	are	be	VBP
cord-015021-pol2qm74	192	7	stimulated	stimulate	VBN
cord-015021-pol2qm74	192	8	to	to	TO
cord-015021-pol2qm74	192	9	secrete	secrete	VB
cord-015021-pol2qm74	192	10	or	or	CC
cord-015021-pol2qm74	192	11	express	express	VB
cord-015021-pol2qm74	192	12	multiple	multiple	JJ
cord-015021-pol2qm74	192	13	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	192	14	mediators	mediator	NNS
cord-015021-pol2qm74	192	15	,	,	,
cord-015021-pol2qm74	192	16	including	include	VBG
cord-015021-pol2qm74	192	17	TNF	TNF	NNP
cord-015021-pol2qm74	192	18	-	-	HYPH
cord-015021-pol2qm74	192	19	a	a	NNP
cord-015021-pol2qm74	192	20	,	,	,
cord-015021-pol2qm74	192	21	ILla	ILla	NNP
cord-015021-pol2qm74	192	22	,	,	,
cord-015021-pol2qm74	192	23	IL-1/3	IL-1/3	NNP
cord-015021-pol2qm74	192	24	,	,	,
cord-015021-pol2qm74	192	25	IFN	IFN	NNP
cord-015021-pol2qm74	192	26	-	-	HYPH
cord-015021-pol2qm74	192	27	a	a	NNP
cord-015021-pol2qm74	192	28	,	,	,
cord-015021-pol2qm74	192	29	IL-6	IL-6	NNP
cord-015021-pol2qm74	192	30	,	,	,
cord-015021-pol2qm74	192	31	IL-8	IL-8	NNP
cord-015021-pol2qm74	192	32	,	,	,
cord-015021-pol2qm74	192	33	IL-10	IL-10	NNP
cord-015021-pol2qm74	192	34	,	,	,
cord-015021-pol2qm74	192	35	PAF	PAF	NNP
cord-015021-pol2qm74	192	36	,	,	,
cord-015021-pol2qm74	192	37	PGE	PGE	NNP
cord-015021-pol2qm74	192	38	,	,	,
cord-015021-pol2qm74	192	39	LTB	LTB	NNP
cord-015021-pol2qm74	192	40	4	4	CD
cord-015021-pol2qm74	192	41	and	and	CC
cord-015021-pol2qm74	192	42	procoagulant	procoagulant	NN
cord-015021-pol2qm74	192	43	activity	activity	NN
cord-015021-pol2qm74	192	44	.	.	.
cord-015021-pol2qm74	193	1	The	the	DT
cord-015021-pol2qm74	193	2	overproduction	overproduction	NN
cord-015021-pol2qm74	193	3	of	of	IN
cord-015021-pol2qm74	193	4	these	these	DT
cord-015021-pol2qm74	193	5	proinfiammatory	proinfiammatory	JJ
cord-015021-pol2qm74	193	6	mediators	mediator	NNS
cord-015021-pol2qm74	193	7	results	result	VBZ
cord-015021-pol2qm74	193	8	in	in	IN
cord-015021-pol2qm74	193	9	the	the	DT
cord-015021-pol2qm74	193	10	manifestations	manifestation	NNS
cord-015021-pol2qm74	193	11	of	of	IN
cord-015021-pol2qm74	193	12	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	193	13	,	,	,
cord-015021-pol2qm74	193	14	observed	observe	VBD
cord-015021-pol2qm74	193	15	experimentally	experimentally	RB
cord-015021-pol2qm74	193	16	as	as	IN
cord-015021-pol2qm74	193	17	fever	fever	NN
cord-015021-pol2qm74	193	18	,	,	,
cord-015021-pol2qm74	193	19	hypotension	hypotension	NN
cord-015021-pol2qm74	193	20	,	,	,
cord-015021-pol2qm74	193	21	disseminated	disseminate	VBN
cord-015021-pol2qm74	193	22	intravascular	intravascular	JJ
cord-015021-pol2qm74	193	23	coagulation	coagulation	NN
cord-015021-pol2qm74	193	24	and	and	CC
cord-015021-pol2qm74	193	25	death	death	NN
cord-015021-pol2qm74	193	26	.	.	.
cord-015021-pol2qm74	194	1	Modulation	modulation	NN
cord-015021-pol2qm74	194	2	of	of	IN
cord-015021-pol2qm74	194	3	activity	activity	NN
cord-015021-pol2qm74	194	4	of	of	IN
cord-015021-pol2qm74	194	5	these	these	DT
cord-015021-pol2qm74	194	6	mediators	mediator	NNS
cord-015021-pol2qm74	194	7	protects	protect	VBZ
cord-015021-pol2qm74	194	8	animals	animal	NNS
cord-015021-pol2qm74	194	9	against	against	IN
cord-015021-pol2qm74	194	10	lethality	lethality	NN
cord-015021-pol2qm74	194	11	.	.	.
cord-015021-pol2qm74	195	1	Similar	similar	JJ
cord-015021-pol2qm74	195	2	pathways	pathway	NNS
cord-015021-pol2qm74	195	3	are	be	VBP
cord-015021-pol2qm74	195	4	thought	think	VBN
cord-015021-pol2qm74	195	5	to	to	TO
cord-015021-pol2qm74	195	6	be	be	VB
cord-015021-pol2qm74	195	7	operative	operative	JJ
cord-015021-pol2qm74	195	8	in	in	IN
cord-015021-pol2qm74	195	9	Gram	Gram	NNP
cord-015021-pol2qm74	195	10	negative	negative	JJ
cord-015021-pol2qm74	195	11	sepsis	sepsis	NN
cord-015021-pol2qm74	195	12	,	,	,
cord-015021-pol2qm74	195	13	and	and	CC
cord-015021-pol2qm74	195	14	control	control	NN
cord-015021-pol2qm74	195	15	studies	study	NNS
cord-015021-pol2qm74	195	16	with	with	IN
cord-015021-pol2qm74	195	17	human	human	JJ
cord-015021-pol2qm74	195	18	volunteers	volunteer	NNS
cord-015021-pol2qm74	195	19	support	support	VBP
cord-015021-pol2qm74	195	20	such	such	JJ
cord-015021-pol2qm74	195	21	conclusions	conclusion	NNS
cord-015021-pol2qm74	195	22	.	.	.
cord-015021-pol2qm74	196	1	Immunotherapeutic	immunotherapeutic	JJ
cord-015021-pol2qm74	196	2	approaches	approach	NNS
cord-015021-pol2qm74	196	3	in	in	IN
cord-015021-pol2qm74	196	4	clinical	clinical	JJ
cord-015021-pol2qm74	196	5	Gram	Gram	NNP
cord-015021-pol2qm74	196	6	negative	negative	JJ
cord-015021-pol2qm74	196	7	sepsis	sepsis	NN
cord-015021-pol2qm74	196	8	have	have	VBP
cord-015021-pol2qm74	196	9	,	,	,
cord-015021-pol2qm74	196	10	to	to	IN
cord-015021-pol2qm74	196	11	date	date	NN
cord-015021-pol2qm74	196	12	,	,	,
cord-015021-pol2qm74	196	13	been	be	VBN
cord-015021-pol2qm74	196	14	less	less	RBR
cord-015021-pol2qm74	196	15	successful	successful	JJ
cord-015021-pol2qm74	196	16	.	.	.
cord-015021-pol2qm74	197	1	In	in	IN
cord-015021-pol2qm74	197	2	vitro	vitro	FW
cord-015021-pol2qm74	197	3	experiments	experiment	NNS
cord-015021-pol2qm74	197	4	and	and	CC
cord-015021-pol2qm74	197	5	studies	study	NNS
cord-015021-pol2qm74	197	6	in	in	IN
cord-015021-pol2qm74	197	7	animal	animal	NN
cord-015021-pol2qm74	197	8	models	model	NNS
cord-015021-pol2qm74	197	9	have	have	VBP
cord-015021-pol2qm74	197	10	recently	recently	RB
cord-015021-pol2qm74	197	11	shown	show	VBN
cord-015021-pol2qm74	197	12	that	that	IN
cord-015021-pol2qm74	197	13	several	several	JJ
cord-015021-pol2qm74	197	14	proteinaceous	proteinaceous	JJ
cord-015021-pol2qm74	197	15	bacterial	bacterial	JJ
cord-015021-pol2qm74	197	16	exotoxins	exotoxin	NNS
cord-015021-pol2qm74	197	17	can	can	MD
cord-015021-pol2qm74	197	18	evoke	evoke	VB
cord-015021-pol2qm74	197	19	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	197	20	effects	effect	NNS
cord-015021-pol2qm74	197	21	that	that	WDT
cord-015021-pol2qm74	197	22	ultimately	ultimately	RB
cord-015021-pol2qm74	197	23	lead	lead	VBP
cord-015021-pol2qm74	197	24	to	to	IN
cord-015021-pol2qm74	197	25	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	197	26	collapse	collapse	NN
cord-015021-pol2qm74	197	27	and	and	CC
cord-015021-pol2qm74	197	28	shock	shock	NN
cord-015021-pol2qm74	197	29	.	.	.
cord-015021-pol2qm74	198	1	Since	since	IN
cord-015021-pol2qm74	198	2	the	the	DT
cord-015021-pol2qm74	198	3	possible	possible	JJ
cord-015021-pol2qm74	198	4	relevance	relevance	NN
cord-015021-pol2qm74	198	5	of	of	IN
cord-015021-pol2qm74	198	6	bacterial	bacterial	JJ
cord-015021-pol2qm74	198	7	exotoxins	exotoxin	NNS
cord-015021-pol2qm74	198	8	in	in	IN
cord-015021-pol2qm74	198	9	the	the	DT
cord-015021-pol2qm74	198	10	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	198	11	of	of	IN
cord-015021-pol2qm74	198	12	septic	septic	JJ
cord-015021-pol2qm74	198	13	shock	shock	NN
cord-015021-pol2qm74	198	14	has	have	VBZ
cord-015021-pol2qm74	198	15	received	receive	VBN
cord-015021-pol2qm74	198	16	very	very	RB
cord-015021-pol2qm74	198	17	little	little	JJ
cord-015021-pol2qm74	198	18	attention	attention	NN
cord-015021-pol2qm74	198	19	in	in	IN
cord-015021-pol2qm74	198	20	the	the	DT
cord-015021-pol2qm74	198	21	past	past	NN
cord-015021-pol2qm74	198	22	,	,	,
cord-015021-pol2qm74	198	23	an	an	DT
cord-015021-pol2qm74	198	24	attempt	attempt	NN
cord-015021-pol2qm74	198	25	will	will	MD
cord-015021-pol2qm74	198	26	be	be	VB
cord-015021-pol2qm74	198	27	made	make	VBN
cord-015021-pol2qm74	198	28	here	here	RB
cord-015021-pol2qm74	198	29	to	to	TO
cord-015021-pol2qm74	198	30	provide	provide	VB
cord-015021-pol2qm74	198	31	a	a	DT
cord-015021-pol2qm74	198	32	brief	brief	JJ
cord-015021-pol2qm74	198	33	overview	overview	NN
cord-015021-pol2qm74	198	34	of	of	IN
cord-015021-pol2qm74	198	35	this	this	DT
cord-015021-pol2qm74	198	36	generaily	generaily	RB
cord-015021-pol2qm74	198	37	neglected	neglect	VBD
cord-015021-pol2qm74	198	38	topic	topic	NN
cord-015021-pol2qm74	198	39	.	.	.
cord-015021-pol2qm74	199	1	Protein	protein	NN
cord-015021-pol2qm74	199	2	toxins	toxin	NNS
cord-015021-pol2qm74	199	3	act	act	VBP
cord-015021-pol2qm74	199	4	intracellularly	intracellularly	RB
cord-015021-pol2qm74	199	5	or	or	CC
cord-015021-pol2qm74	199	6	they	-PRON-	PRP
cord-015021-pol2qm74	199	7	dz	dz	NNP
cord-015021-pol2qm74	200	1	~nage	~nage	NFP
cord-015021-pol2qm74	201	1	the	the	DT
cord-015021-pol2qm74	201	2	integrity	integrity	NN
cord-015021-pol2qm74	201	3	and	and	CC
cord-015021-pol2qm74	201	4	function	function	NN
cord-015021-pol2qm74	201	5	of	of	IN
cord-015021-pol2qm74	201	6	the	the	DT
cord-015021-pol2qm74	201	7	plasma	plasma	NN
cord-015021-pol2qm74	201	8	membrane	membrane	NN
cord-015021-pol2qm74	201	9	.	.	.
cord-015021-pol2qm74	202	1	Major	major	JJ
cord-015021-pol2qm74	202	2	representatives	representative	NNS
cord-015021-pol2qm74	202	3	of	of	IN
cord-015021-pol2qm74	202	4	the	the	DT
cord-015021-pol2qm74	202	5	former	former	JJ
cord-015021-pol2qm74	202	6	group	group	NN
cord-015021-pol2qm74	202	7	are	be	VBP
cord-015021-pol2qm74	202	8	the	the	DT
cord-015021-pol2qm74	202	9	adenosine	adenosine	NN
cord-015021-pol2qm74	202	10	diphosphate	diphosphate	NN
cord-015021-pol2qm74	202	11	(	(	-LRB-
cord-015021-pol2qm74	202	12	ADP)-ribosylating	adp)-ribosylate	VBG
cord-015021-pol2qm74	202	13	toxins	toxin	NNS
cord-015021-pol2qm74	202	14	,	,	,
cord-015021-pol2qm74	202	15	e.g.	e.g.	RB
cord-015021-pol2qm74	202	16	cholera	cholera	NN
cord-015021-pol2qm74	202	17	and	and	CC
cord-015021-pol2qm74	202	18	cholera	cholera	NN
cord-015021-pol2qm74	202	19	-	-	HYPH
cord-015021-pol2qm74	202	20	like	like	JJ
cord-015021-pol2qm74	202	21	toxins	toxin	NNS
cord-015021-pol2qm74	202	22	,	,	,
cord-015021-pol2qm74	202	23	diphtheria	diphtheria	NN
cord-015021-pol2qm74	202	24	toxin	toxin	NN
cord-015021-pol2qm74	202	25	)	)	-RRB-
cord-015021-pol2qm74	202	26	,	,	,
cord-015021-pol2qm74	202	27	and	and	CC
cord-015021-pol2qm74	202	28	the	the	DT
cord-015021-pol2qm74	202	29	neurotoxins	neurotoxin	NNS
cord-015021-pol2qm74	202	30	.	.	.
cord-015021-pol2qm74	203	1	Most	most	RBS
cord-015021-pol2qm74	203	2	medically	medically	RB
cord-015021-pol2qm74	203	3	relevant	relevant	JJ
cord-015021-pol2qm74	203	4	toxins	toxin	NNS
cord-015021-pol2qm74	203	5	of	of	IN
cord-015021-pol2qm74	203	6	this	this	DT
cord-015021-pol2qm74	203	7	category	category	NN
cord-015021-pol2qm74	203	8	have	have	VBP
cord-015021-pol2qm74	203	9	been	be	VBN
cord-015021-pol2qm74	203	10	studied	study	VBN
cord-015021-pol2qm74	203	11	in	in	IN
cord-015021-pol2qm74	203	12	great	great	JJ
cord-015021-pol2qm74	203	13	detail	detail	NN
cord-015021-pol2qm74	203	14	.	.	.
cord-015021-pol2qm74	204	1	Although	although	IN
cord-015021-pol2qm74	204	2	often	often	RB
cord-015021-pol2qm74	204	3	responsible	responsible	JJ
cord-015021-pol2qm74	204	4	for	for	IN
cord-015021-pol2qm74	204	5	severe	severe	JJ
cord-015021-pol2qm74	204	6	and	and	CC
cord-015021-pol2qm74	204	7	sometimes	sometimes	RB
cord-015021-pol2qm74	204	8	fatal	fatal	JJ
cord-015021-pol2qm74	204	9	disease	disease	NN
cord-015021-pol2qm74	204	10	,	,	,
cord-015021-pol2qm74	204	11	their	-PRON-	PRP$
cord-015021-pol2qm74	204	12	association	association	NN
cord-015021-pol2qm74	204	13	with	with	IN
cord-015021-pol2qm74	204	14	septic	septic	JJ
cord-015021-pol2qm74	204	15	shock	shock	NN
cord-015021-pol2qm74	204	16	is	be	VBZ
cord-015021-pol2qm74	204	17	rare	rare	JJ
cord-015021-pol2qm74	204	18	.	.	.
cord-015021-pol2qm74	205	1	In	in	IN
cord-015021-pol2qm74	205	2	contrast	contrast	NN
cord-015021-pol2qm74	205	3	,	,	,
cord-015021-pol2qm74	205	4	experimental	experimental	JJ
cord-015021-pol2qm74	205	5	evidence	evidence	NN
cord-015021-pol2qm74	205	6	is	be	VBZ
cord-015021-pol2qm74	205	7	accumulating	accumulate	VBG
cord-015021-pol2qm74	205	8	for	for	IN
cord-015021-pol2qm74	205	9	a	a	DT
cord-015021-pol2qm74	205	10	role	role	NN
cord-015021-pol2qm74	205	11	of	of	IN
cord-015021-pol2qm74	205	12	membrane	membrane	NN
cord-015021-pol2qm74	205	13	<	<	XX
cord-015021-pol2qm74	205	14	lamaging	lamage	VBG
cord-015021-pol2qm74	205	15	toxins	toxin	NNS
cord-015021-pol2qm74	205	16	in	in	IN
cord-015021-pol2qm74	205	17	the	the	DT
cord-015021-pol2qm74	205	18	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	205	19	of	of	IN
cord-015021-pol2qm74	205	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	205	21	lesions	lesion	NNS
cord-015021-pol2qm74	205	22	.	.	.
cord-015021-pol2qm74	206	1	Formation	formation	NN
cord-015021-pol2qm74	206	2	of	of	IN
cord-015021-pol2qm74	206	3	transmembrane	transmembrane	NN
cord-015021-pol2qm74	206	4	pores	pore	NNS
cord-015021-pol2qm74	206	5	is	be	VBZ
cord-015021-pol2qm74	206	6	probably	probably	RB
cord-015021-pol2qm74	206	7	the	the	DT
cord-015021-pol2qm74	206	8	most	most	RBS
cord-015021-pol2qm74	206	9	widespread	widespread	JJ
cord-015021-pol2qm74	206	10	mechanism	mechanism	NN
cord-015021-pol2qm74	206	11	via	via	IN
cord-015021-pol2qm74	206	12	which	which	WDT
cord-015021-pol2qm74	206	13	such	such	JJ
cord-015021-pol2qm74	206	14	physical	physical	JJ
cord-015021-pol2qm74	206	15	membrane	membrane	NN
cord-015021-pol2qm74	206	16	perturbation	perturbation	NN
cord-015021-pol2qm74	206	17	can	can	MD
cord-015021-pol2qm74	206	18	occur	occur	VB
cord-015021-pol2qm74	206	19	(	(	-LRB-
cord-015021-pol2qm74	206	20	1,2	1,2	CD
cord-015021-pol2qm74	206	21	)	)	-RRB-
cord-015021-pol2qm74	206	22	,	,	,
cord-015021-pol2qm74	206	23	the	the	DT
cord-015021-pol2qm74	206	24	present	present	JJ
cord-015021-pol2qm74	206	25	discussion	discussion	NN
cord-015021-pol2qm74	206	26	will	will	MD
cord-015021-pol2qm74	206	27	be	be	VB
cord-015021-pol2qm74	206	28	restricted	restrict	VBN
cord-015021-pol2qm74	206	29	to	to	IN
cord-015021-pol2qm74	206	30	this	this	DT
cord-015021-pol2qm74	206	31	category	category	NN
cord-015021-pol2qm74	206	32	of	of	IN
cord-015021-pol2qm74	206	33	toxins	toxin	NNS
cord-015021-pol2qm74	206	34	.	.	.
cord-015021-pol2qm74	207	1	The	the	DT
cord-015021-pol2qm74	207	2	author	author	NN
cord-015021-pol2qm74	207	3	shall	shall	MD
cord-015021-pol2qm74	207	4	first	first	RB
cord-015021-pol2qm74	207	5	discuss	discuss	VB
cord-015021-pol2qm74	207	6	basic	basic	JJ
cord-015021-pol2qm74	207	7	properties	property	NNS
cord-015021-pol2qm74	207	8	of	of	IN
cord-015021-pol2qm74	207	9	pore	pore	NN
cord-015021-pol2qm74	207	10	-	-	HYPH
cord-015021-pol2qm74	207	11	forming	form	VBG
cord-015021-pol2qm74	207	12	proteins	protein	NNS
cord-015021-pol2qm74	207	13	,	,	,
cord-015021-pol2qm74	207	14	and	and	CC
cord-015021-pol2qm74	207	15	consider	consider	VB
cord-015021-pol2qm74	207	16	the	the	DT
cord-015021-pol2qm74	207	17	factors	factor	NNS
cord-015021-pol2qm74	207	18	that	that	WDT
cord-015021-pol2qm74	207	19	direct	direct	VBP
cord-015021-pol2qm74	207	20	their	-PRON-	PRP$
cord-015021-pol2qm74	207	21	attack	attack	NN
cord-015021-pol2qm74	207	22	to	to	IN
cord-015021-pol2qm74	207	23	specific	specific	JJ
cord-015021-pol2qm74	207	24	targets	target	NNS
cord-015021-pol2qm74	207	25	.	.	.
cord-015021-pol2qm74	208	1	Thereafter	thereafter	RB
cord-015021-pol2qm74	208	2	,	,	,
cord-015021-pol2qm74	208	3	attention	attention	NN
cord-015021-pol2qm74	208	4	will	will	MD
cord-015021-pol2qm74	208	5	be	be	VB
cord-015021-pol2qm74	208	6	drawn	draw	VBN
cord-015021-pol2qm74	208	7	to	to	IN
cord-015021-pol2qm74	208	8	diverse	diverse	JJ
cord-015021-pol2qm74	208	9	functional	functional	JJ
cord-015021-pol2qm74	208	10	consequences	consequence	NNS
cord-015021-pol2qm74	208	11	that	that	WDT
cord-015021-pol2qm74	208	12	may	may	MD
cord-015021-pol2qm74	208	13	follow	follow	VB
cord-015021-pol2qm74	208	14	membrane	membrane	NN
cord-015021-pol2qm74	208	15	damage	damage	NN
cord-015021-pol2qm74	208	16	so	so	IN
cord-015021-pol2qm74	208	17	that	that	IN
cord-015021-pol2qm74	208	18	a	a	DT
cord-015021-pol2qm74	208	19	general	general	JJ
cord-015021-pol2qm74	208	20	concept	concept	NN
cord-015021-pol2qm74	208	21	of	of	IN
cord-015021-pol2qm74	208	22	how	how	WRB
cord-015021-pol2qm74	208	23	pore	pore	NN
cord-015021-pol2qm74	208	24	-	-	HYPH
cord-015021-pol2qm74	208	25	forming	form	VBG
cord-015021-pol2qm74	208	26	toxins	toxin	NNS
cord-015021-pol2qm74	208	27	may	may	MD
cord-015021-pol2qm74	208	28	contribute	contribute	VB
cord-015021-pol2qm74	208	29	towards	towards	IN
cord-015021-pol2qm74	208	30	the	the	DT
cord-015021-pol2qm74	208	31	development	development	NN
cord-015021-pol2qm74	208	32	of	of	IN
cord-015021-pol2qm74	208	33	shock	shock	NN
cord-015021-pol2qm74	208	34	will	will	MD
cord-015021-pol2qm74	208	35	evolve	evolve	VB
cord-015021-pol2qm74	208	36	.	.	.
cord-015021-pol2qm74	209	1	I.	I.	NNP
cord-015021-pol2qm74	209	2	Bhakdi	Bhakdi	NNP
cord-015021-pol2qm74	209	3	,	,	,
cord-015021-pol2qm74	209	4	S.	S.	NNP
cord-015021-pol2qm74	209	5	and	and	CC
cord-015021-pol2qm74	209	6	Tranum	Tranum	NNP
cord-015021-pol2qm74	209	7	-	-	HYPH
cord-015021-pol2qm74	209	8	Jensen	Jensen	NNP
cord-015021-pol2qm74	209	9	.	.	.
cord-015021-pol2qm74	210	1	J.	J.	NNP
cord-015021-pol2qm74	210	2	1987	1987	CD
cord-015021-pol2qm74	211	1	Gram	gram	NN
cord-015021-pol2qm74	211	2	positive	positive	JJ
cord-015021-pol2qm74	211	3	bacteria	bacteria	NNS
cord-015021-pol2qm74	211	4	produce	produce	VBP
cord-015021-pol2qm74	211	5	exotoxins	exotoxin	NNS
cord-015021-pol2qm74	211	6	that	that	IN
cord-015021-pol2qm74	211	7	,	,	,
cord-015021-pol2qm74	211	8	at	at	IN
cord-015021-pol2qm74	211	9	least	least	JJS
cord-015021-pol2qm74	211	10	in	in	IN
cord-015021-pol2qm74	211	11	part	part	NN
cord-015021-pol2qm74	211	12	,	,	,
cord-015021-pol2qm74	211	13	exhibit	exhibit	VB
cord-015021-pol2qm74	211	14	the	the	DT
cord-015021-pol2qm74	211	15	unusual	unusual	JJ
cord-015021-pol2qm74	211	16	properties	property	NNS
cord-015021-pol2qm74	211	17	of	of	IN
cord-015021-pol2qm74	211	18	superantigens	superantigen	NNS
cord-015021-pol2qm74	211	19	.	.	.
cord-015021-pol2qm74	212	1	Superantigens	Superantigens	NNP
cord-015021-pol2qm74	212	2	(	(	-LRB-
cord-015021-pol2qm74	212	3	SAg	SAg	NNS
cord-015021-pol2qm74	212	4	)	)	-RRB-
cord-015021-pol2qm74	212	5	activate	activate	VBP
cord-015021-pol2qm74	212	6	V/3	V/3	NNP
cord-015021-pol2qm74	212	7	selectively	selectively	RB
cord-015021-pol2qm74	212	8	T	t	NN
cord-015021-pol2qm74	212	9	cells	cell	NNS
cord-015021-pol2qm74	212	10	to	to	TO
cord-015021-pol2qm74	212	11	produce	produce	VB
cord-015021-pol2qm74	212	12	lymphokines	lymphokine	NNS
cord-015021-pol2qm74	212	13	including	include	VBG
cord-015021-pol2qm74	212	14	I1	i1	NN
cord-015021-pol2qm74	212	15	-	-	HYPH
cord-015021-pol2qm74	212	16	2	2	NNP
cord-015021-pol2qm74	212	17	and	and	CC
cord-015021-pol2qm74	212	18	TNF	TNF	NNP
cord-015021-pol2qm74	212	19	/	/	SYM
cord-015021-pol2qm74	212	20	lymphotoxin	lymphotoxin	NNP
cord-015021-pol2qm74	212	21	.	.	.
cord-015021-pol2qm74	213	1	Systemic	systemic	JJ
cord-015021-pol2qm74	213	2	application	application	NN
cord-015021-pol2qm74	213	3	of	of	IN
cord-015021-pol2qm74	213	4	the	the	DT
cord-015021-pol2qm74	213	5	SAg	SAg	NNS
cord-015021-pol2qm74	213	6	staphylococcal	staphylococcal	JJ
cord-015021-pol2qm74	213	7	enterotoxin	enterotoxin	NNP
cord-015021-pol2qm74	213	8	B	B	NNP
cord-015021-pol2qm74	213	9	(	(	-LRB-
cord-015021-pol2qm74	213	10	SEB	SEB	NNP
cord-015021-pol2qm74	213	11	)	)	-RRB-
cord-015021-pol2qm74	213	12	to	to	IN
cord-015021-pol2qm74	213	13	D	D	NNP
cord-015021-pol2qm74	213	14	-	-	HYPH
cord-015021-pol2qm74	213	15	galactosamine	galactosamine	NN
cord-015021-pol2qm74	213	16	sensitized	sensitize	VBN
cord-015021-pol2qm74	213	17	mice	mouse	NNS
cord-015021-pol2qm74	213	18	causes	cause	VBZ
cord-015021-pol2qm74	213	19	lethal	lethal	JJ
cord-015021-pol2qm74	213	20	shock	shock	NN
cord-015021-pol2qm74	213	21	within	within	IN
cord-015021-pol2qm74	213	22	hours	hour	NNS
cord-015021-pol2qm74	213	23	.	.	.
cord-015021-pol2qm74	214	1	SEB	SEB	NNP
cord-015021-pol2qm74	214	2	reactive	reactive	JJ
cord-015021-pol2qm74	215	1	V/38	V/38	NNP
cord-015021-pol2qm74	215	2	+	+	CC
cord-015021-pol2qm74	215	3	T	t	NN
cord-015021-pol2qm74	215	4	cells	cell	NNS
cord-015021-pol2qm74	215	5	accumulate	accumulate	VBP
cord-015021-pol2qm74	215	6	within	within	IN
cord-015021-pol2qm74	215	7	90	90	CD
cord-015021-pol2qm74	215	8	-	-	SYM
cord-015021-pol2qm74	215	9	120	120	CD
cord-015021-pol2qm74	215	10	min	min	NN
cord-015021-pol2qm74	215	11	mRNA	mrna	NN
cord-015021-pol2qm74	215	12	for	for	IN
cord-015021-pol2qm74	215	13	the	the	DT
cord-015021-pol2qm74	215	14	II-2	II-2	NNP
cord-015021-pol2qm74	215	15	,	,	,
cord-015021-pol2qm74	215	16	I1	i1	NN
cord-015021-pol2qm74	215	17	-	-	HYPH
cord-015021-pol2qm74	215	18	4	4	CD
cord-015021-pol2qm74	215	19	,	,	,
cord-015021-pol2qm74	215	20	TNFaI~	TNFaI~	NNP
cord-015021-pol2qm74	215	21	and	and	CC
cord-015021-pol2qm74	215	22	IFN-3	IFN-3	NNP
cord-015021-pol2qm74	215	23	,	,	,
cord-015021-pol2qm74	215	24	.	.	.
cord-015021-pol2qm74	216	1	Parallel	parallel	JJ
cord-015021-pol2qm74	216	2	in	in	IN
cord-015021-pol2qm74	216	3	time	time	NN
cord-015021-pol2qm74	216	4	high	high	JJ
cord-015021-pol2qm74	216	5	concentrations	concentration	NNS
cord-015021-pol2qm74	216	6	of	of	IN
cord-015021-pol2qm74	216	7	bloodborne	bloodborne	JJ
cord-015021-pol2qm74	216	8	I1	i1	NN
cord-015021-pol2qm74	216	9	-	-	HYPH
cord-015021-pol2qm74	216	10	2	2	NNP
cord-015021-pol2qm74	216	11	and	and	CC
cord-015021-pol2qm74	216	12	TNF	TNF	NNP
cord-015021-pol2qm74	216	13	are	be	VBP
cord-015021-pol2qm74	216	14	noted	note	VBN
cord-015021-pol2qm74	216	15	.	.	.
cord-015021-pol2qm74	217	1	Anti	Anti	NNP
cord-015021-pol2qm74	217	2	TNF	TNF	NNP
cord-015021-pol2qm74	217	3	t~//3	t~//3	IN
cord-015021-pol2qm74	217	4	neutralizing	neutralize	VBG
cord-015021-pol2qm74	217	5	mAb	mab	JJ
cord-015021-pol2qm74	217	6	protect	protect	JJ
cord-015021-pol2qm74	217	7	mice	mouse	NNS
cord-015021-pol2qm74	217	8	against	against	IN
cord-015021-pol2qm74	217	9	SEB	SEB	NNP
cord-015021-pol2qm74	217	10	induced	induce	VBD
cord-015021-pol2qm74	217	11	T	T	NNP
cord-015021-pol2qm74	217	12	cell	cell	NN
cord-015021-pol2qm74	217	13	dependent	dependent	JJ
cord-015021-pol2qm74	217	14	lethal	lethal	JJ
cord-015021-pol2qm74	217	15	shock	shock	NN
cord-015021-pol2qm74	217	16	thus	thus	RB
cord-015021-pol2qm74	217	17	indicating	indicate	VBG
cord-015021-pol2qm74	217	18	a	a	DT
cord-015021-pol2qm74	217	19	key	key	JJ
cord-015021-pol2qm74	217	20	role	role	NN
cord-015021-pol2qm74	217	21	of	of	IN
cord-015021-pol2qm74	217	22	TNF	TNF	NNP
cord-015021-pol2qm74	217	23	in	in	IN
cord-015021-pol2qm74	217	24	effecting	effect	VBG
cord-015021-pol2qm74	217	25	lethal	lethal	JJ
cord-015021-pol2qm74	217	26	toxicity	toxicity	NN
cord-015021-pol2qm74	217	27	.	.	.
cord-015021-pol2qm74	218	1	Within	within	IN
cord-015021-pol2qm74	218	2	12	12	CD
cord-015021-pol2qm74	218	3	-	-	SYM
cord-015021-pol2qm74	218	4	18	18	CD
cord-015021-pol2qm74	218	5	h	h	NN
cord-015021-pol2qm74	218	6	distinct	distinct	JJ
cord-015021-pol2qm74	218	7	levels	level	NNS
cord-015021-pol2qm74	218	8	of	of	IN
cord-015021-pol2qm74	218	9	tolerance	tolerance	NN
cord-015021-pol2qm74	218	10	to	to	IN
cord-015021-pol2qm74	218	11	SEB	SEB	NNP
cord-015021-pol2qm74	218	12	become	become	VBP
cord-015021-pol2qm74	218	13	discernable	discernable	JJ
cord-015021-pol2qm74	218	14	on	on	IN
cord-015021-pol2qm74	218	15	ligand	ligand	NN
cord-015021-pol2qm74	218	16	reactive	reactive	JJ
cord-015021-pol2qm74	218	17	V/38	V/38	NNP
cord-015021-pol2qm74	218	18	T	T	NNP
cord-015021-pol2qm74	218	19	ceils	ceil	NNS
cord-015021-pol2qm74	218	20	,	,	,
cord-015021-pol2qm74	218	21	dependent	dependent	JJ
cord-015021-pol2qm74	218	22	of	of	IN
cord-015021-pol2qm74	218	23	the	the	DT
cord-015021-pol2qm74	218	24	dose	dose	NN
cord-015021-pol2qm74	218	25	of	of	IN
cord-015021-pol2qm74	218	26	SEB	SEB	NNP
cord-015021-pol2qm74	218	27	used	use	VBD
cord-015021-pol2qm74	218	28	.	.	.
cord-015021-pol2qm74	219	1	These	these	DT
cord-015021-pol2qm74	219	2	levels	level	NNS
cord-015021-pol2qm74	219	3	include	include	VBP
cord-015021-pol2qm74	219	4	anergy	anergy	NNP
cord-015021-pol2qm74	219	5	,	,	,
cord-015021-pol2qm74	219	6	T	T	NNP
cord-015021-pol2qm74	219	7	cell	cell	NN
cord-015021-pol2qm74	219	8	receptor	receptor	NN
cord-015021-pol2qm74	219	9	downregulation	downregulation	NN
cord-015021-pol2qm74	219	10	,	,	,
cord-015021-pol2qm74	219	11	loss	loss	NN
cord-015021-pol2qm74	219	12	of	of	IN
cord-015021-pol2qm74	219	13	CD2	CD2	NNP
cord-015021-pol2qm74	219	14	,	,	,
cord-015021-pol2qm74	219	15	CD4	CD4	NNP
cord-015021-pol2qm74	219	16	,	,	,
cord-015021-pol2qm74	219	17	CD8	CD8	NNP
cord-015021-pol2qm74	219	18	accessory	accessory	NN
cord-015021-pol2qm74	219	19	molecules	molecule	NNS
cord-015021-pol2qm74	219	20	and	and	CC
cord-015021-pol2qm74	219	21	programmed	program	VBD
cord-015021-pol2qm74	219	22	cell	cell	NN
cord-015021-pol2qm74	219	23	death	death	NN
cord-015021-pol2qm74	219	24	.	.	.
cord-015021-pol2qm74	220	1	M.Freudenberg	M.Freudenberg	NNP
cord-015021-pol2qm74	220	2	,	,	,
cord-015021-pol2qm74	220	3	Y.Yaegashi	Y.Yaegashi	NNP
cord-015021-pol2qm74	220	4	,	,	,
cord-015021-pol2qm74	220	5	P.Nielsen	P.Nielsen	NNP
cord-015021-pol2qm74	220	6	,	,	,
cord-015021-pol2qm74	220	7	C.Galanos	C.Galanos	NNP
cord-015021-pol2qm74	220	8	.	.	.
cord-015021-pol2qm74	221	1	The	the	DT
cord-015021-pol2qm74	221	2	sensitivity	sensitivity	NN
cord-015021-pol2qm74	221	3	towards	towards	IN
cord-015021-pol2qm74	221	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	221	5	(	(	-LRB-
cord-015021-pol2qm74	221	6	LPS	LPS	NNP
cord-015021-pol2qm74	221	7	)	)	-RRB-
cord-015021-pol2qm74	221	8	is	be	VBZ
cord-015021-pol2qm74	221	9	genetically	genetically	RB
cord-015021-pol2qm74	221	10	determined	determine	VBN
cord-015021-pol2qm74	221	11	,	,	,
cord-015021-pol2qm74	221	12	however	however	RB
cord-015021-pol2qm74	221	13	it	-PRON-	PRP
cord-015021-pol2qm74	221	14	may	may	MD
cord-015021-pol2qm74	221	15	be	be	VB
cord-015021-pol2qm74	221	16	increased	increase	VBN
cord-015021-pol2qm74	221	17	under	under	IN
cord-015021-pol2qm74	221	18	different	different	JJ
cord-015021-pol2qm74	221	19	experimental	experimental	JJ
cord-015021-pol2qm74	221	20	conditions	condition	NNS
cord-015021-pol2qm74	221	21	.	.	.
cord-015021-pol2qm74	222	1	These	these	DT
cord-015021-pol2qm74	222	2	include	include	VBP
cord-015021-pol2qm74	222	3	treatment	treatment	NN
cord-015021-pol2qm74	222	4	with	with	IN
cord-015021-pol2qm74	222	5	hepatotoxic	hepatotoxic	JJ
cord-015021-pol2qm74	222	6	agents	agent	NNS
cord-015021-pol2qm74	222	7	such	such	JJ
cord-015021-pol2qm74	222	8	as	as	IN
cord-015021-pol2qm74	222	9	D	d	NN
cord-015021-pol2qm74	222	10	-	-	HYPH
cord-015021-pol2qm74	222	11	galactosamine	galactosamine	NN
cord-015021-pol2qm74	222	12	,	,	,
cord-015021-pol2qm74	222	13	and	and	CC
cord-015021-pol2qm74	222	14	with	with	IN
cord-015021-pol2qm74	222	15	live	live	JJ
cord-015021-pol2qm74	222	16	(	(	-LRB-
cord-015021-pol2qm74	222	17	infection	infection	NN
cord-015021-pol2qm74	222	18	)	)	-RRB-
cord-015021-pol2qm74	222	19	or	or	CC
cord-015021-pol2qm74	222	20	killed	kill	VBD
cord-015021-pol2qm74	222	21	bacteria	bacteria	NNS
cord-015021-pol2qm74	222	22	.	.	.
cord-015021-pol2qm74	223	1	It	-PRON-	PRP
cord-015021-pol2qm74	223	2	is	be	VBZ
cord-015021-pol2qm74	223	3	well	well	RB
cord-015021-pol2qm74	223	4	established	establish	VBN
cord-015021-pol2qm74	223	5	now	now	RB
cord-015021-pol2qm74	223	6	that	that	IN
cord-015021-pol2qm74	223	7	D	d	NN
cord-015021-pol2qm74	223	8	-	-	HYPH
cord-015021-pol2qm74	223	9	galactosamine	galactosamine	NN
cord-015021-pol2qm74	223	10	sensitizes	sensitize	VBZ
cord-015021-pol2qm74	223	11	to	to	IN
cord-015021-pol2qm74	223	12	LPS	LPS	NNP
cord-015021-pol2qm74	223	13	by	by	IN
cord-015021-pol2qm74	223	14	increasing	increase	VBG
cord-015021-pol2qm74	223	15	the	the	DT
cord-015021-pol2qm74	223	16	susceptibility	susceptibility	NN
cord-015021-pol2qm74	223	17	of	of	IN
cord-015021-pol2qm74	223	18	the	the	DT
cord-015021-pol2qm74	223	19	host	host	NN
cord-015021-pol2qm74	223	20	to	to	IN
cord-015021-pol2qm74	223	21	toxic	toxic	JJ
cord-015021-pol2qm74	223	22	activity	activity	NN
cord-015021-pol2qm74	223	23	of	of	IN
cord-015021-pol2qm74	223	24	LPS	LPS	NNP
cord-015021-pol2qm74	223	25	-	-	HYPH
cord-015021-pol2qm74	223	26	induced	induce	VBN
cord-015021-pol2qm74	223	27	TNF~.	TNF~.	NNP
cord-015021-pol2qm74	223	28	Sensitization	sensitization	NN
cord-015021-pol2qm74	223	29	by	by	IN
cord-015021-pol2qm74	223	30	bacteria	bacteria	NNS
cord-015021-pol2qm74	223	31	,	,	,
cord-015021-pol2qm74	223	32	especially	especially	RB
cord-015021-pol2qm74	223	33	by	by	IN
cord-015021-pol2qm74	223	34	Gram	gram	NN
cord-015021-pol2qm74	223	35	-	-	HYPH
cord-015021-pol2qm74	223	36	negative	negative	JJ
cord-015021-pol2qm74	223	37	once	once	RB
cord-015021-pol2qm74	223	38	is	be	VBZ
cord-015021-pol2qm74	223	39	of	of	IN
cord-015021-pol2qm74	223	40	especial	especial	JJ
cord-015021-pol2qm74	223	41	interest	interest	NN
cord-015021-pol2qm74	223	42	because	because	IN
cord-015021-pol2qm74	223	43	it	-PRON-	PRP
cord-015021-pol2qm74	223	44	implies	imply	VBZ
cord-015021-pol2qm74	223	45	that	that	IN
cord-015021-pol2qm74	223	46	infecting	infect	VBG
cord-015021-pol2qm74	223	47	microorganisms	microorganism	NNS
cord-015021-pol2qm74	223	48	not	not	RB
cord-015021-pol2qm74	223	49	only	only	RB
cord-015021-pol2qm74	223	50	produce	produce	VBP
cord-015021-pol2qm74	223	51	LPS	lp	NNS
cord-015021-pol2qm74	223	52	,	,	,
cord-015021-pol2qm74	223	53	but	but	CC
cord-015021-pol2qm74	223	54	als0	als0	TO
cord-015021-pol2qm74	223	55	sensitize	sensitize	VB
cord-015021-pol2qm74	223	56	the	the	DT
cord-015021-pol2qm74	223	57	host	host	NN
cord-015021-pol2qm74	223	58	to	to	IN
cord-015021-pol2qm74	223	59	its	-PRON-	PRP$
cord-015021-pol2qm74	223	60	lethal	lethal	JJ
cord-015021-pol2qm74	223	61	activity	activity	NN
cord-015021-pol2qm74	223	62	.	.	.
cord-015021-pol2qm74	224	1	Sensitization	sensitization	NN
cord-015021-pol2qm74	224	2	to	to	IN
cord-015021-pol2qm74	224	3	LPS	LPS	NNP
cord-015021-pol2qm74	224	4	by	by	IN
cord-015021-pol2qm74	224	5	bacteria	bacteria	NNS
cord-015021-pol2qm74	224	6	proceeds	proceed	NNS
cord-015021-pol2qm74	224	7	in	in	IN
cord-015021-pol2qm74	224	8	all	all	DT
cord-015021-pol2qm74	224	9	LPS	LPS	NNP
cord-015021-pol2qm74	224	10	-	-	HYPH
cord-015021-pol2qm74	224	11	sensitive	sensitive	JJ
cord-015021-pol2qm74	224	12	(	(	-LRB-
cord-015021-pol2qm74	224	13	Lps	Lps	NNP
cord-015021-pol2qm74	224	14	n	n	NNP
cord-015021-pol2qm74	224	15	)	)	-RRB-
cord-015021-pol2qm74	224	16	mouse	mouse	NN
cord-015021-pol2qm74	224	17	strains	strain	NNS
cord-015021-pol2qm74	224	18	that	that	WDT
cord-015021-pol2qm74	224	19	have	have	VBP
cord-015021-pol2qm74	224	20	been	be	VBN
cord-015021-pol2qm74	224	21	investigated	investigate	VBN
cord-015021-pol2qm74	224	22	so	so	RB
cord-015021-pol2qm74	224	23	far	far	RB
cord-015021-pol2qm74	224	24	.	.	.
cord-015021-pol2qm74	225	1	It	-PRON-	PRP
cord-015021-pol2qm74	225	2	also	also	RB
cord-015021-pol2qm74	225	3	proceeds	proceed	VBZ
cord-015021-pol2qm74	225	4	in	in	IN
cord-015021-pol2qm74	225	5	LPS	lps	NN
cord-015021-pol2qm74	225	6	-	-	HYPH
cord-015021-pol2qm74	225	7	resistant	resistant	JJ
cord-015021-pol2qm74	225	8	(	(	-LRB-
cord-015021-pol2qm74	225	9	Lps	Lps	NNP
cord-015021-pol2qm74	225	10	d	d	NN
cord-015021-pol2qm74	225	11	)	)	-RRB-
cord-015021-pol2qm74	226	1	C3H	C3H	NNP
cord-015021-pol2qm74	226	2	/	/	SYM
cord-015021-pol2qm74	226	3	HeJ	HeJ	NNP
cord-015021-pol2qm74	226	4	mice	mouse	NNS
cord-015021-pol2qm74	226	5	.	.	.
cord-015021-pol2qm74	227	1	The	the	DT
cord-015021-pol2qm74	227	2	absence	absence	NN
cord-015021-pol2qm74	227	3	of	of	IN
cord-015021-pol2qm74	227	4	sensitization	sensitization	NN
cord-015021-pol2qm74	227	5	to	to	IN
cord-015021-pol2qm74	227	6	LPS	LPS	NNP
cord-015021-pol2qm74	227	7	in	in	IN
cord-015021-pol2qm74	227	8	Lps	Lps	NNP
cord-015021-pol2qm74	227	9	d	d	NNP
cord-015021-pol2qm74	227	10	C57BL/10ScCr	C57BL/10ScCr	NNP
cord-015021-pol2qm74	227	11	mice	mouse	NNS
cord-015021-pol2qm74	227	12	was	be	VBD
cord-015021-pol2qm74	227	13	identified	identify	VBN
cord-015021-pol2qm74	227	14	as	as	IN
cord-015021-pol2qm74	227	15	being	be	VBG
cord-015021-pol2qm74	227	16	due	due	JJ
cord-015021-pol2qm74	227	17	to	to	IN
cord-015021-pol2qm74	227	18	their	-PRON-	PRP$
cord-015021-pol2qm74	227	19	inability	inability	NN
cord-015021-pol2qm74	227	20	to	to	TO
cord-015021-pol2qm74	227	21	produce	produce	VB
cord-015021-pol2qm74	227	22	interferon-7	interferon-7	PRP
cord-015021-pol2qm74	227	23	(	(	-LRB-
cord-015021-pol2qm74	227	24	IFN	IFN	NNP
cord-015021-pol2qm74	227	25	?	?	.
cord-015021-pol2qm74	227	26	)	)	-RRB-
cord-015021-pol2qm74	227	27	.	.	.
cord-015021-pol2qm74	228	1	Administration	administration	NN
cord-015021-pol2qm74	228	2	of	of	IN
cord-015021-pol2qm74	228	3	exogenous	exogenous	JJ
cord-015021-pol2qm74	228	4	IFN	IFN	NNP
cord-015021-pol2qm74	228	5	?	?	.
cord-015021-pol2qm74	229	1	to	to	IN
cord-015021-pol2qm74	229	2	these	these	DT
cord-015021-pol2qm74	229	3	mice	mouse	NNS
cord-015021-pol2qm74	229	4	conferred	confer	VBD
cord-015021-pol2qm74	229	5	sensitivity	sensitivity	NN
cord-015021-pol2qm74	229	6	to	to	IN
cord-015021-pol2qm74	229	7	LPS	lp	NNS
cord-015021-pol2qm74	229	8	.	.	.
cord-015021-pol2qm74	230	1	Conversely	conversely	RB
cord-015021-pol2qm74	230	2	,	,	,
cord-015021-pol2qm74	230	3	administration	administration	NN
cord-015021-pol2qm74	230	4	of	of	IN
cord-015021-pol2qm74	230	5	anti	anti	NNP
cord-015021-pol2qm74	230	6	-	-	NNP
cord-015021-pol2qm74	230	7	IFN	IFN	NNP
cord-015021-pol2qm74	230	8	?	?	.
cord-015021-pol2qm74	231	1	to	to	IN
cord-015021-pol2qm74	231	2	Lpsn	Lpsn	NNP
cord-015021-pol2qm74	231	3	;	;	:
cord-015021-pol2qm74	231	4	mice	mouse	NNS
cord-015021-pol2qm74	231	5	inhibited	inhibit	VBD
cord-015021-pol2qm74	231	6	the	the	DT
cord-015021-pol2qm74	231	7	development	development	NN
cord-015021-pol2qm74	231	8	of	of	IN
cord-015021-pol2qm74	231	9	sensitization'by	sensitization'by	NN
cord-015021-pol2qm74	231	10	bacteria	bacteria	NNS
cord-015021-pol2qm74	231	11	.	.	.
cord-015021-pol2qm74	232	1	It	-PRON-	PRP
cord-015021-pol2qm74	232	2	may	may	MD
cord-015021-pol2qm74	232	3	be	be	VB
cord-015021-pol2qm74	232	4	concluded	conclude	VBN
cord-015021-pol2qm74	232	5	therefore	therefore	RB
cord-015021-pol2qm74	232	6	that	that	IN
cord-015021-pol2qm74	232	7	IFN7	IFN7	NNP
cord-015021-pol2qm74	232	8	is	be	VBZ
cord-015021-pol2qm74	232	9	the	the	DT
cord-015021-pol2qm74	232	10	mediator	mediator	NN
cord-015021-pol2qm74	232	11	of	of	IN
cord-015021-pol2qm74	232	12	sensitization	sensitization	NN
cord-015021-pol2qm74	232	13	to	to	IN
cord-015021-pol2qm74	232	14	LPS	lp	NNS
cord-015021-pol2qm74	232	15	by	by	IN
cord-015021-pol2qm74	232	16	bacterial	bacterial	JJ
cord-015021-pol2qm74	232	17	infection	infection	NN
cord-015021-pol2qm74	232	18	.	.	.
cord-015021-pol2qm74	233	1	The	the	DT
cord-015021-pol2qm74	233	2	IFN	IFN	NNP
cord-015021-pol2qm74	233	3	?	?	.
cord-015021-pol2qm74	234	1	defect	defect	NN
cord-015021-pol2qm74	234	2	of	of	IN
cord-015021-pol2qm74	234	3	C57BL/10ScCr	c57bl/10sccr	JJ
cord-015021-pol2qm74	234	4	mice	mouse	NNS
cord-015021-pol2qm74	234	5	concerns	concern	VBZ
cord-015021-pol2qm74	234	6	only	only	RB
cord-015021-pol2qm74	234	7	the	the	DT
cord-015021-pol2qm74	234	8	IFN7	IFN7	NNP
cord-015021-pol2qm74	234	9	response	response	NN
cord-015021-pol2qm74	234	10	to	to	IN
cord-015021-pol2qm74	234	11	bacteria	bacteria	NNS
cord-015021-pol2qm74	234	12	,	,	,
cord-015021-pol2qm74	234	13	since	since	IN
cord-015021-pol2qm74	234	14	the	the	DT
cord-015021-pol2qm74	234	15	response	response	NN
cord-015021-pol2qm74	234	16	to	to	IN
cord-015021-pol2qm74	234	17	the	the	DT
cord-015021-pol2qm74	234	18	T	t	NN
cord-015021-pol2qm74	234	19	-	-	HYPH
cord-015021-pol2qm74	234	20	cell	cell	NN
cord-015021-pol2qm74	234	21	mitogen	mitogen	NNP
cord-015021-pol2qm74	234	22	Con	Con	NNP
cord-015021-pol2qm74	234	23	A	A	NNP
cord-015021-pol2qm74	234	24	and	and	CC
cord-015021-pol2qm74	234	25	to	to	IN
cord-015021-pol2qm74	234	26	CD3	CD3	NNP
cord-015021-pol2qm74	234	27	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	234	28	antibodies	antibody	NNS
cord-015021-pol2qm74	234	29	was	be	VBD
cord-015021-pol2qm74	234	30	not	not	RB
cord-015021-pol2qm74	234	31	impaired	impaired	JJ
cord-015021-pol2qm74	234	32	.	.	.
cord-015021-pol2qm74	235	1	The	the	DT
cord-015021-pol2qm74	235	2	IFN?producing	ifn?producing	NN
cord-015021-pol2qm74	235	3	cells	cell	NNS
cord-015021-pol2qm74	235	4	themselves	-PRON-	PRP
cord-015021-pol2qm74	235	5	were	be	VBD
cord-015021-pol2qm74	235	6	shown	show	VBN
cord-015021-pol2qm74	235	7	to	to	TO
cord-015021-pol2qm74	235	8	be	be	VB
cord-015021-pol2qm74	235	9	intact	intact	JJ
cord-015021-pol2qm74	235	10	.	.	.
cord-015021-pol2qm74	236	1	On	on	IN
cord-015021-pol2qm74	236	2	closer	close	JJR
cord-015021-pol2qm74	236	3	investigation	investigation	NN
cord-015021-pol2qm74	236	4	the	the	DT
cord-015021-pol2qm74	236	5	impaired	impaired	JJ
cord-015021-pol2qm74	236	6	IFN	IFN	NNP
cord-015021-pol2qm74	236	7	?	?	.
cord-015021-pol2qm74	237	1	response	response	NN
cord-015021-pol2qm74	237	2	was	be	VBD
cord-015021-pol2qm74	237	3	identified	identify	VBN
cord-015021-pol2qm74	237	4	as	as	IN
cord-015021-pol2qm74	237	5	the	the	DT
cord-015021-pol2qm74	237	6	result	result	NN
cord-015021-pol2qm74	237	7	of	of	IN
cord-015021-pol2qm74	237	8	a	a	DT
cord-015021-pol2qm74	237	9	defective	defective	JJ
cord-015021-pol2qm74	237	10	accessory	accessory	NN
cord-015021-pol2qm74	237	11	function	function	NN
cord-015021-pol2qm74	237	12	of	of	IN
cord-015021-pol2qm74	237	13	macrophages	macrophage	NNS
cord-015021-pol2qm74	237	14	.	.	.
cord-015021-pol2qm74	238	1	Macrophages	macrophage	NNS
cord-015021-pol2qm74	238	2	of	of	IN
cord-015021-pol2qm74	238	3	C57BL/10ScCr	c57bl/10sccr	JJ
cord-015021-pol2qm74	238	4	mice	mouse	NNS
cord-015021-pol2qm74	238	5	are	be	VBP
cord-015021-pol2qm74	238	6	incapable	incapable	JJ
cord-015021-pol2qm74	238	7	of	of	IN
cord-015021-pol2qm74	238	8	producing	produce	VBG
cord-015021-pol2qm74	238	9	interferon-~	interferon-~	NNP
cord-015021-pol2qm74	238	10	(	(	-LRB-
cord-015021-pol2qm74	238	11	IFN~	ifn~	NN
cord-015021-pol2qm74	238	12	)	)	-RRB-
cord-015021-pol2qm74	238	13	which	which	WDT
cord-015021-pol2qm74	238	14	we	-PRON-	PRP
cord-015021-pol2qm74	238	15	could	could	MD
cord-015021-pol2qm74	238	16	show	show	VB
cord-015021-pol2qm74	238	17	to	to	TO
cord-015021-pol2qm74	238	18	be	be	VB
cord-015021-pol2qm74	238	19	obligatory	obligatory	JJ
cord-015021-pol2qm74	238	20	for	for	IN
cord-015021-pol2qm74	238	21	the	the	DT
cord-015021-pol2qm74	238	22	production	production	NN
cord-015021-pol2qm74	238	23	of	of	IN
cord-015021-pol2qm74	238	24	IFN	IFN	NNP
cord-015021-pol2qm74	238	25	?	?	.
cord-015021-pol2qm74	239	1	in	in	IN
cord-015021-pol2qm74	239	2	response	response	NN
cord-015021-pol2qm74	239	3	to	to	IN
cord-015021-pol2qm74	239	4	bacteria	bacteria	NNS
cord-015021-pol2qm74	239	5	.	.	.
cord-015021-pol2qm74	240	1	Although	although	IN
cord-015021-pol2qm74	240	2	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	240	3	are	be	VBP
cord-015021-pol2qm74	240	4	required	require	VBN
cord-015021-pol2qm74	240	5	to	to	TO
cord-015021-pol2qm74	240	6	clear	clear	VB
cord-015021-pol2qm74	240	7	bacteremia	bacteremia	NN
cord-015021-pol2qm74	240	8	,	,	,
cord-015021-pol2qm74	240	9	they	-PRON-	PRP
cord-015021-pol2qm74	240	10	do	do	VBP
cord-015021-pol2qm74	240	11	not	not	RB
cord-015021-pol2qm74	240	12	reverse	reverse	VB
cord-015021-pol2qm74	240	13	evolving	evolve	VBG
cord-015021-pol2qm74	240	14	shock	shock	NN
cord-015021-pol2qm74	240	15	,	,	,
cord-015021-pol2qm74	241	1	because	because	IN
cord-015021-pol2qm74	241	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	241	3	free	free	JJ
cord-015021-pol2qm74	241	4	in	in	IN
cord-015021-pol2qm74	241	5	the	the	DT
cord-015021-pol2qm74	241	6	bloodstream	bloodstream	NN
cord-015021-pol2qm74	241	7	or	or	CC
cord-015021-pol2qm74	241	8	exposed	expose	VBN
cord-015021-pol2qm74	241	9	on	on	IN
cord-015021-pol2qm74	241	10	the	the	DT
cord-015021-pol2qm74	241	11	surface	surface	NN
cord-015021-pol2qm74	241	12	of	of	IN
cord-015021-pol2qm74	241	13	circulating	circulate	VBG
cord-015021-pol2qm74	241	14	bacteria	bacteria	NNS
cord-015021-pol2qm74	241	15	continues	continue	VBZ
cord-015021-pol2qm74	241	16	to	to	TO
cord-015021-pol2qm74	241	17	activate	activate	VB
cord-015021-pol2qm74	241	18	the	the	DT
cord-015021-pol2qm74	241	19	production	production	NN
cord-015021-pol2qm74	241	20	of	of	IN
cord-015021-pol2qm74	241	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	241	22	mediators	mediator	NNS
cord-015021-pol2qm74	241	23	,	,	,
cord-015021-pol2qm74	241	24	Furthermore	furthermore	RB
cord-015021-pol2qm74	241	25	,	,	,
cord-015021-pol2qm74	241	26	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	241	27	have	have	VBP
cord-015021-pol2qm74	241	28	been	be	VBN
cord-015021-pol2qm74	241	29	shown	show	VBN
cord-015021-pol2qm74	241	30	to	to	TO
cord-015021-pol2qm74	241	31	induce	induce	VB
cord-015021-pol2qm74	241	32	release	release	NN
cord-015021-pol2qm74	241	33	of	of	IN
cord-015021-pol2qm74	241	34	endotoxin	endotoxin	NN
cord-015021-pol2qm74	241	35	from	from	IN
cord-015021-pol2qm74	241	36	gram	gram	JJ
cord-015021-pol2qm74	241	37	-	-	HYPH
cord-015021-pol2qm74	241	38	negative	negative	JJ
cord-015021-pol2qm74	241	39	bacteria	bacteria	NNS
cord-015021-pol2qm74	241	40	during	during	IN
cord-015021-pol2qm74	241	41	the	the	DT
cord-015021-pol2qm74	241	42	treatment	treatment	NN
cord-015021-pol2qm74	241	43	of	of	IN
cord-015021-pol2qm74	241	44	severe	severe	JJ
cord-015021-pol2qm74	241	45	infection	infection	NN
cord-015021-pol2qm74	241	46	.	.	.
cord-015021-pol2qm74	242	1	In	in	IN
cord-015021-pol2qm74	242	2	an	an	DT
cord-015021-pol2qm74	242	3	in	in	IN
cord-015021-pol2qm74	242	4	-	-	HYPH
cord-015021-pol2qm74	242	5	vitro	vitro	FW
cord-015021-pol2qm74	242	6	study	study	NN
cord-015021-pol2qm74	242	7	,	,	,
cord-015021-pol2qm74	242	8	using	use	VBG
cord-015021-pol2qm74	242	9	live	live	JJ
cord-015021-pol2qm74	242	10	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	242	11	coil	coil	NN
cord-015021-pol2qm74	242	12	,	,	,
cord-015021-pol2qm74	242	13	we	-PRON-	PRP
cord-015021-pol2qm74	242	14	have	have	VBP
cord-015021-pol2qm74	242	15	observed	observe	VBN
cord-015021-pol2qm74	242	16	the	the	DT
cord-015021-pol2qm74	242	17	release	release	NN
cord-015021-pol2qm74	242	18	of	of	IN
cord-015021-pol2qm74	242	19	endotoxin	endotoxin	NN
cord-015021-pol2qm74	242	20	upon	upon	IN
cord-015021-pol2qm74	242	21	treatment	treatment	NN
cord-015021-pol2qm74	242	22	with	with	IN
cord-015021-pol2qm74	242	23	several	several	JJ
cord-015021-pol2qm74	242	24	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	242	25	like	like	IN
cord-015021-pol2qm74	242	26	cefuroxim	cefuroxim	NNS
cord-015021-pol2qm74	242	27	,	,	,
cord-015021-pol2qm74	242	28	imipenem	imipenem	NNP
cord-015021-pol2qm74	242	29	,	,	,
cord-015021-pol2qm74	242	30	ceftazidime	ceftazidime	NNP
cord-015021-pol2qm74	242	31	and	and	CC
cord-015021-pol2qm74	242	32	aztreonam	aztreonam	NNP
cord-015021-pol2qm74	242	33	.	.	.
cord-015021-pol2qm74	243	1	Incubation	Incubation	NNP
cord-015021-pol2qm74	243	2	with	with	IN
cord-015021-pol2qm74	243	3	imipenem	imipenem	NNP
cord-015021-pol2qm74	243	4	or	or	CC
cord-015021-pol2qm74	243	5	ceftazidime	ceftazidime	NNP
cord-015021-pol2qm74	243	6	induced	induce	VBD
cord-015021-pol2qm74	243	7	an	an	DT
cord-015021-pol2qm74	243	8	early	early	JJ
cord-015021-pol2qm74	243	9	lyeis	lyeis	NN
cord-015021-pol2qm74	243	10	and	and	CC
cord-015021-pol2qm74	243	11	a	a	DT
cord-015021-pol2qm74	243	12	mild	mild	JJ
cord-015021-pol2qm74	243	13	rise	rise	NN
cord-015021-pol2qm74	243	14	in	in	IN
cord-015021-pol2qm74	243	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	243	16	levels	level	NNS
cord-015021-pol2qm74	243	17	,	,	,
cord-015021-pol2qm74	243	18	whereas	whereas	IN
cord-015021-pol2qm74	243	19	incubation	incubation	NN
cord-015021-pol2qm74	243	20	with	with	IN
cord-015021-pol2qm74	243	21	cefuroxime	cefuroxime	NNP
cord-015021-pol2qm74	243	22	or	or	CC
cord-015021-pol2qm74	243	23	aztreonam	aztreonam	NNP
cord-015021-pol2qm74	243	24	resulted	result	VBD
cord-015021-pol2qm74	243	25	in	in	IN
cord-015021-pol2qm74	243	26	the	the	DT
cord-015021-pol2qm74	243	27	formation	formation	NN
cord-015021-pol2qm74	243	28	of	of	IN
cord-015021-pol2qm74	243	29	filaments	filament	NNS
cord-015021-pol2qm74	243	30	with	with	IN
cord-015021-pol2qm74	243	31	a	a	DT
cord-015021-pol2qm74	243	32	late	late	JJ
cord-015021-pol2qm74	243	33	but	but	CC
cord-015021-pol2qm74	243	34	dramatic	dramatic	JJ
cord-015021-pol2qm74	243	35	rise	rise	NN
cord-015021-pol2qm74	243	36	in	in	IN
cord-015021-pol2qm74	243	37	endotoxin	endotoxin	NN
cord-015021-pol2qm74	243	38	levels	level	NNS
cord-015021-pol2qm74	243	39	.	.	.
cord-015021-pol2qm74	244	1	In	in	IN
cord-015021-pol2qm74	244	2	a	a	DT
cord-015021-pol2qm74	244	3	second	second	JJ
cord-015021-pol2qm74	244	4	study	study	NN
cord-015021-pol2qm74	244	5	we	-PRON-	PRP
cord-015021-pol2qm74	244	6	studied	study	VBD
cord-015021-pol2qm74	244	7	the	the	DT
cord-015021-pol2qm74	244	8	influence	influence	NN
cord-015021-pol2qm74	244	9	of	of	IN
cord-015021-pol2qm74	244	10	different	different	JJ
cord-015021-pol2qm74	244	11	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	244	12	on	on	IN
cord-015021-pol2qm74	244	13	the	the	DT
cord-015021-pol2qm74	244	14	TNF-=	tnf-=	CD
cord-015021-pol2qm74	244	15	production	production	NN
cord-015021-pol2qm74	244	16	of	of	IN
cord-015021-pol2qm74	244	17	E.coli	E.coli	NNS
cord-015021-pol2qm74	244	18	stimulated	stimulate	VBD
cord-015021-pol2qm74	244	19	human	human	JJ
cord-015021-pol2qm74	244	20	monocytes	monocyte	NNS
cord-015021-pol2qm74	244	21	.	.	.
cord-015021-pol2qm74	245	1	We	-PRON-	PRP
cord-015021-pol2qm74	245	2	found	find	VBD
cord-015021-pol2qm74	245	3	again	again	RB
cord-015021-pol2qm74	245	4	great	great	JJ
cord-015021-pol2qm74	245	5	differences	difference	NNS
cord-015021-pol2qm74	245	6	in	in	IN
cord-015021-pol2qm74	245	7	the	the	DT
cord-015021-pol2qm74	245	8	production	production	NN
cord-015021-pol2qm74	245	9	of	of	IN
cord-015021-pol2qm74	245	10	this	this	DT
cord-015021-pol2qm74	245	11	important	important	JJ
cord-015021-pol2qm74	245	12	cytokine	cytokine	NN
cord-015021-pol2qm74	245	13	among	among	IN
cord-015021-pol2qm74	245	14	the	the	DT
cord-015021-pol2qm74	245	15	different	different	JJ
cord-015021-pol2qm74	245	16	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	245	17	according	accord	VBG
cord-015021-pol2qm74	245	18	to	to	IN
cord-015021-pol2qm74	245	19	their	-PRON-	PRP$
cord-015021-pol2qm74	245	20	capacity	capacity	NN
cord-015021-pol2qm74	245	21	to	to	TO
cord-015021-pol2qm74	245	22	induce	induce	VB
cord-015021-pol2qm74	245	23	liberation	liberation	NN
cord-015021-pol2qm74	245	24	of	of	IN
cord-015021-pol2qm74	245	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	245	26	.	.	.
cord-015021-pol2qm74	246	1	These	these	DT
cord-015021-pol2qm74	246	2	differences	difference	NNS
cord-015021-pol2qm74	246	3	in	in	IN
cord-015021-pol2qm74	246	4	the	the	DT
cord-015021-pol2qm74	246	5	amount	amount	NN
cord-015021-pol2qm74	246	6	of	of	IN
cord-015021-pol2qm74	246	7	endotoxin	endotoxin	NN
cord-015021-pol2qm74	246	8	release	release	NN
cord-015021-pol2qm74	246	9	are	be	VBP
cord-015021-pol2qm74	246	10	probably	probably	RB
cord-015021-pol2qm74	246	11	caused	cause	VBN
cord-015021-pol2qm74	246	12	by	by	IN
cord-015021-pol2qm74	246	13	Penicillin	Penicillin	NNP
cord-015021-pol2qm74	246	14	-	-	HYPH
cord-015021-pol2qm74	246	15	Binding	Binding	NNP
cord-015021-pol2qm74	246	16	-	-	HYPH
cord-015021-pol2qm74	246	17	Proteins	Proteins	NNP
cord-015021-pol2qm74	246	18	(	(	-LRB-
cord-015021-pol2qm74	246	19	PBP	PBP	NNP
cord-015021-pol2qm74	246	20	)	)	-RRB-
cord-015021-pol2qm74	246	21	specificities	specificity	NNS
cord-015021-pol2qm74	246	22	of	of	IN
cord-015021-pol2qm74	246	23	the	the	DT
cord-015021-pol2qm74	246	24	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	246	25	with	with	IN
cord-015021-pol2qm74	246	26	resultant	resultant	JJ
cord-015021-pol2qm74	246	27	differential	differential	JJ
cord-015021-pol2qm74	246	28	morphological	morphological	JJ
cord-015021-pol2qm74	246	29	changes	change	NNS
cord-015021-pol2qm74	246	30	,	,	,
cord-015021-pol2qm74	246	31	In	in	IN
cord-015021-pol2qm74	246	32	a	a	DT
cord-015021-pol2qm74	246	33	rat	rat	NN
cord-015021-pol2qm74	246	34	sepsis	sepsis	NN
cord-015021-pol2qm74	246	35	model	model	NN
cord-015021-pol2qm74	246	36	treatment	treatment	NN
cord-015021-pol2qm74	246	37	with	with	IN
cord-015021-pol2qm74	246	38	imipenem	imipenem	NNP
cord-015021-pol2qm74	246	39	or	or	CC
cord-015021-pol2qm74	246	40	ceftazidime	ceftazidime	NNP
cord-015021-pol2qm74	246	41	resulted	result	VBD
cord-015021-pol2qm74	246	42	in	in	IN
cord-015021-pol2qm74	246	43	a	a	DT
cord-015021-pol2qm74	246	44	transient	transient	JJ
cord-015021-pol2qm74	246	45	increase	increase	NN
cord-015021-pol2qm74	246	46	in	in	IN
cord-015021-pol2qm74	246	47	IL-6	IL-6	NNP
cord-015021-pol2qm74	246	48	levels	level	NNS
cord-015021-pol2qm74	246	49	,	,	,
cord-015021-pol2qm74	246	50	whereas	whereas	IN
cord-015021-pol2qm74	246	51	treatment	treatment	NN
cord-015021-pol2qm74	246	52	with	with	IN
cord-015021-pol2qm74	246	53	aztreonam	aztreonam	NNP
cord-015021-pol2qm74	246	54	resulted	result	VBD
cord-015021-pol2qm74	246	55	in	in	IN
cord-015021-pol2qm74	246	56	progressively	progressively	RB
cord-015021-pol2qm74	246	57	increasing	increase	VBG
cord-015021-pol2qm74	246	58	levels	level	NNS
cord-015021-pol2qm74	246	59	of	of	IN
cord-015021-pol2qm74	246	60	IL-6	IL-6	NNP
cord-015021-pol2qm74	246	61	and	and	CC
cord-015021-pol2qm74	246	62	a	a	DT
cord-015021-pol2qm74	246	63	significant	significant	JJ
cord-015021-pol2qm74	246	64	increase	increase	NN
cord-015021-pol2qm74	246	65	in	in	IN
cord-015021-pol2qm74	246	66	mortality	mortality	NN
cord-015021-pol2qm74	246	67	.	.	.
cord-015021-pol2qm74	247	1	The	the	DT
cord-015021-pol2qm74	247	2	increased	increased	JJ
cord-015021-pol2qm74	247	3	mortality	mortality	NN
cord-015021-pol2qm74	247	4	in	in	IN
cord-015021-pol2qm74	247	5	PBP-3	PBP-3	NNP
cord-015021-pol2qm74	247	6	specific	specific	JJ
cord-015021-pol2qm74	247	7	aztreonam	aztreonam	NN
cord-015021-pol2qm74	247	8	treated	treat	VBD
cord-015021-pol2qm74	247	9	rats	rat	NNS
cord-015021-pol2qm74	247	10	might	may	MD
cord-015021-pol2qm74	247	11	have	have	VB
cord-015021-pol2qm74	247	12	been	be	VBN
cord-015021-pol2qm74	247	13	the	the	DT
cord-015021-pol2qm74	247	14	result	result	NN
cord-015021-pol2qm74	247	15	of	of	IN
cord-015021-pol2qm74	247	16	filament	filament	NN
cord-015021-pol2qm74	247	17	formation	formation	NN
cord-015021-pol2qm74	247	18	in	in	IN
cord-015021-pol2qm74	247	19	the	the	DT
cord-015021-pol2qm74	247	20	abdominal	abdominal	JJ
cord-015021-pol2qm74	247	21	cavity	cavity	NN
cord-015021-pol2qm74	247	22	of	of	IN
cord-015021-pol2qm74	247	23	the	the	DT
cord-015021-pol2qm74	247	24	septic	septic	JJ
cord-015021-pol2qm74	247	25	rats	rat	NNS
cord-015021-pol2qm74	247	26	.	.	.
cord-015021-pol2qm74	248	1	The	the	DT
cord-015021-pol2qm74	248	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	248	3	sequestered	sequester	VBN
cord-015021-pol2qm74	248	4	at	at	IN
cord-015021-pol2qm74	248	5	local	local	JJ
cord-015021-pol2qm74	248	6	sites	site	NNS
cord-015021-pol2qm74	248	7	may	may	MD
cord-015021-pol2qm74	248	8	account	account	VB
cord-015021-pol2qm74	248	9	for	for	IN
cord-015021-pol2qm74	248	10	the	the	DT
cord-015021-pol2qm74	248	11	precipitation	precipitation	NN
cord-015021-pol2qm74	248	12	of	of	IN
cord-015021-pol2qm74	248	13	gram	gram	NN
cord-015021-pol2qm74	248	14	-	-	HYPH
cord-015021-pol2qm74	248	15	negative	negative	JJ
cord-015021-pol2qm74	248	16	shock	shock	NN
cord-015021-pol2qm74	248	17	.	.	.
cord-015021-pol2qm74	249	1	Finally	finally	RB
cord-015021-pol2qm74	249	2	,	,	,
cord-015021-pol2qm74	249	3	we	-PRON-	PRP
cord-015021-pol2qm74	249	4	've	have	VB
cord-015021-pol2qm74	249	5	also	also	RB
cord-015021-pol2qm74	249	6	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	249	7	that	that	IN
cord-015021-pol2qm74	249	8	in	in	IN
cord-015021-pol2qm74	249	9	patients	patient	NNS
cord-015021-pol2qm74	249	10	under	under	IN
cord-015021-pol2qm74	249	11	treatment	treatment	NN
cord-015021-pol2qm74	249	12	for	for	IN
cord-015021-pol2qm74	249	13	septic	septic	JJ
cord-015021-pol2qm74	249	14	shock	shock	NN
cord-015021-pol2qm74	249	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	249	16	release	release	NN
cord-015021-pol2qm74	249	17	can	can	MD
cord-015021-pol2qm74	249	18	be	be	VB
cord-015021-pol2qm74	249	19	related	relate	VBN
cord-015021-pol2qm74	249	20	to	to	IN
cord-015021-pol2qm74	249	21	the	the	DT
cord-015021-pol2qm74	249	22	administration	administration	NN
cord-015021-pol2qm74	249	23	of	of	IN
cord-015021-pol2qm74	249	24	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	249	25	.	.	.
cord-015021-pol2qm74	250	1	Carbapenem	Carbapenem	NNP
cord-015021-pol2qm74	250	2	-	-	:
cord-015021-pol2qm74	250	3	and	and	CC
cord-015021-pol2qm74	250	4	Cephalosporin	Cephalosporin	NNP
cord-015021-pol2qm74	250	5	-	-	HYPH
cord-015021-pol2qm74	250	6	lnduced	lnduce	VBN
cord-015021-pol2qm74	250	7	Release	Release	NNP
cord-015021-pol2qm74	250	8	of	of	IN
cord-015021-pol2qm74	250	9	LPS	LPS	NNP
cord-015021-pol2qm74	250	10	from	from	IN
cord-015021-pol2qm74	250	11	Smooth	smooth	JJ
cord-015021-pol2qm74	250	12	and	and	CC
cord-015021-pol2qm74	250	13	Rough	rough	JJ
cord-015021-pol2qm74	250	14	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	250	15	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	250	16	:	:	:
cord-015021-pol2qm74	251	1	In	in	IN
cord-015021-pol2qm74	251	2	-	-	HYPH
cord-015021-pol2qm74	251	3	Vivo	Vivo	NNP
cord-015021-pol2qm74	251	4	Relevance	relevance	NN
cord-015021-pol2qm74	251	5	J.	J.	NNP
cord-015021-pol2qm74	251	6	Jackson	Jackson	NNP
cord-015021-pol2qm74	251	7	and	and	CC
cord-015021-pol2qm74	251	8	H.	H.	NNP
cord-015021-pol2qm74	251	9	Kropp	Kropp	NNP
cord-015021-pol2qm74	251	10	,	,	,
cord-015021-pol2qm74	251	11	Merck	Merck	NNP
cord-015021-pol2qm74	251	12	Research	Research	NNP
cord-015021-pol2qm74	251	13	Laboratories	Laboratories	NNP
cord-015021-pol2qm74	251	14	,	,	,
cord-015021-pol2qm74	251	15	Rahway	Rahway	NNP
cord-015021-pol2qm74	251	16	,	,	,
cord-015021-pol2qm74	251	17	NJ	NJ	NNP
cord-015021-pol2qm74	251	18	B	B	NNP
cord-015021-pol2qm74	251	19	-	-	HYPH
cord-015021-pol2qm74	251	20	lactam	lactam	NNP
cord-015021-pol2qm74	251	21	(	(	-LRB-
cord-015021-pol2qm74	251	22	cell	cell	NN
cord-015021-pol2qm74	251	23	-	-	HYPH
cord-015021-pol2qm74	251	24	wall	wall	NN
cord-015021-pol2qm74	251	25	active	active	JJ
cord-015021-pol2qm74	251	26	)	)	-RRB-
cord-015021-pol2qm74	252	1	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	252	2	are	be	VBP
cord-015021-pol2qm74	252	3	generally	generally	RB
cord-015021-pol2qm74	252	4	deemed	deem	VBN
cord-015021-pol2qm74	252	5	the	the	DT
cord-015021-pol2qm74	252	6	class	class	NN
cord-015021-pol2qm74	252	7	of	of	IN
cord-015021-pol2qm74	252	8	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	252	9	most	most	RBS
cord-015021-pol2qm74	252	10	responsible	responsible	JJ
cord-015021-pol2qm74	252	11	for	for	IN
cord-015021-pol2qm74	252	12	the	the	DT
cord-015021-pol2qm74	252	13	release	release	NN
cord-015021-pol2qm74	252	14	of	of	IN
cord-015021-pol2qm74	252	15	free	free	JJ
cord-015021-pol2qm74	252	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	252	17	(	(	-LRB-
cord-015021-pol2qm74	252	18	LPS	LPS	NNP
cord-015021-pol2qm74	252	19	)	)	-RRB-
cord-015021-pol2qm74	252	20	from	from	IN
cord-015021-pol2qm74	252	21	gram	gram	NN
cord-015021-pol2qm74	252	22	-	-	HYPH
cord-015021-pol2qm74	252	23	negative	negative	JJ
cord-015021-pol2qm74	252	24	bacteria	bacteria	NNS
cord-015021-pol2qm74	252	25	due	due	IN
cord-015021-pol2qm74	252	26	to	to	IN
cord-015021-pol2qm74	252	27	their	-PRON-	PRP$
cord-015021-pol2qm74	252	28	cell	cell	NN
cord-015021-pol2qm74	252	29	lytic	lytic	JJ
cord-015021-pol2qm74	252	30	actions	action	NNS
cord-015021-pol2qm74	252	31	although	although	IN
cord-015021-pol2qm74	252	32	all	all	DT
cord-015021-pol2qm74	252	33	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	252	34	classes	class	NNS
cord-015021-pol2qm74	252	35	studied	study	VBD
cord-015021-pol2qm74	252	36	thus	thus	RB
cord-015021-pol2qm74	252	37	far	far	RB
cord-015021-pol2qm74	252	38	induce	induce	VBP
cord-015021-pol2qm74	252	39	release	release	NN
cord-015021-pol2qm74	252	40	of	of	IN
cord-015021-pol2qm74	252	41	endotoxin	endotoxin	NN
cord-015021-pol2qm74	252	42	.	.	.
cord-015021-pol2qm74	253	1	We	-PRON-	PRP
cord-015021-pol2qm74	253	2	have	have	VBP
cord-015021-pol2qm74	253	3	recently	recently	RB
cord-015021-pol2qm74	253	4	shown	show	VBN
cord-015021-pol2qm74	253	5	in	in	IN
cord-015021-pol2qm74	253	6	-	-	HYPH
cord-015021-pol2qm74	253	7	vitro	vitro	FW
cord-015021-pol2qm74	253	8	that	that	IN
cord-015021-pol2qm74	253	9	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	253	10	within	within	IN
cord-015021-pol2qm74	253	11	the	the	DT
cord-015021-pol2qm74	253	12	b	b	NN
cord-015021-pol2qm74	253	13	-	-	HYPH
cord-015021-pol2qm74	253	14	lactam	lactam	NN
cord-015021-pol2qm74	253	15	class	class	NN
cord-015021-pol2qm74	253	16	(	(	-LRB-
cord-015021-pol2qm74	253	17	i.e.	i.e.	FW
cord-015021-pol2qm74	253	18	imipenem	imipenem	NNP
cord-015021-pol2qm74	253	19	,	,	,
cord-015021-pol2qm74	253	20	meropenem	meropenem	NNP
cord-015021-pol2qm74	253	21	and	and	CC
cord-015021-pol2qm74	253	22	ceftazidime	ceftazidime	NNP
cord-015021-pol2qm74	253	23	,	,	,
cord-015021-pol2qm74	253	24	with	with	IN
cord-015021-pol2qm74	253	25	equivalent	equivalent	JJ
cord-015021-pol2qm74	253	26	MICs	mic	NNS
cord-015021-pol2qm74	253	27	)	)	-RRB-
cord-015021-pol2qm74	253	28	differ	differ	VBP
cord-015021-pol2qm74	253	29	in	in	IN
cord-015021-pol2qm74	253	30	their	-PRON-	PRP$
cord-015021-pol2qm74	253	31	propensities	propensity	NNS
cord-015021-pol2qm74	253	32	to	to	TO
cord-015021-pol2qm74	253	33	release	release	VB
cord-015021-pol2qm74	253	34	excessive	excessive	JJ
cord-015021-pol2qm74	253	35	amounts	amount	NNS
cord-015021-pol2qm74	253	36	of	of	IN
cord-015021-pol2qm74	253	37	LPS	lp	NNS
cord-015021-pol2qm74	253	38	from	from	IN
cord-015021-pol2qm74	253	39	both	both	DT
cord-015021-pol2qm74	253	40	smooth-(s-	smooth-(s-	NNS
cord-015021-pol2qm74	253	41	)	)	-RRB-
cord-015021-pol2qm74	253	42	and	and	CC
cord-015021-pol2qm74	253	43	rough-(r-	rough-(r-	NNP
cord-015021-pol2qm74	253	44	)	)	-RRB-
cord-015021-pol2qm74	254	1	LPS	LPS	NNP
cord-015021-pol2qm74	254	2	laboratory	laboratory	NN
cord-015021-pol2qm74	254	3	and	and	CC
cord-015021-pol2qm74	254	4	clinical	clinical	JJ
cord-015021-pol2qm74	254	5	and	and	CC
cord-015021-pol2qm74	254	6	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	254	7	-	-	HYPH
cord-015021-pol2qm74	254	8	sensitive	sensitive	JJ
cord-015021-pol2qm74	254	9	and	and	CC
cord-015021-pol2qm74	254	10	-resistant	-resistant	JJ
cord-015021-pol2qm74	254	11	P.	p.	NN
cord-015021-pol2qm74	254	12	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	254	13	isolates	isolate	NNS
cord-015021-pol2qm74	254	14	and	and	CC
cord-015021-pol2qm74	254	15	that	that	IN
cord-015021-pol2qm74	254	16	LPS	LPS	NNP
cord-015021-pol2qm74	254	17	release	release	NN
cord-015021-pol2qm74	254	18	is	be	VBZ
cord-015021-pol2qm74	254	19	independent	independent	JJ
cord-015021-pol2qm74	254	20	of	of	IN
cord-015021-pol2qm74	254	21	cell	cell	NN
cord-015021-pol2qm74	254	22	lysis	lysis	NN
cord-015021-pol2qm74	254	23	.	.	.
cord-015021-pol2qm74	255	1	Additionally	additionally	RB
cord-015021-pol2qm74	255	2	,	,	,
cord-015021-pol2qm74	255	3	variations	variation	NNS
cord-015021-pol2qm74	255	4	in	in	IN
cord-015021-pol2qm74	255	5	the	the	DT
cord-015021-pol2qm74	255	6	induction	induction	NN
cord-015021-pol2qm74	255	7	of	of	IN
cord-015021-pol2qm74	255	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	255	9	release	release	NN
cord-015021-pol2qm74	255	10	is	be	VBZ
cord-015021-pol2qm74	255	11	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	255	12	concentration	concentration	NN
cord-015021-pol2qm74	255	13	dependant	dependant	JJ
cord-015021-pol2qm74	255	14	and	and	CC
cord-015021-pol2qm74	255	15	correlate	correlate	VB
cord-015021-pol2qm74	255	16	with	with	IN
cord-015021-pol2qm74	255	17	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	255	18	penicillin	penicillin	NN
cord-015021-pol2qm74	255	19	-	-	HYPH
cord-015021-pol2qm74	255	20	binding	bind	VBG
cord-015021-pol2qm74	255	21	protein	protein	NN
cord-015021-pol2qm74	255	22	(	(	-LRB-
cord-015021-pol2qm74	255	23	PBP	PBP	NNP
cord-015021-pol2qm74	255	24	)	)	-RRB-
cord-015021-pol2qm74	255	25	affinities	affinity	NNS
cord-015021-pol2qm74	255	26	which	which	WDT
cord-015021-pol2qm74	255	27	result	result	VBP
cord-015021-pol2qm74	255	28	in	in	IN
cord-015021-pol2qm74	255	29	morphological	morphological	JJ
cord-015021-pol2qm74	255	30	changes	change	NNS
cord-015021-pol2qm74	255	31	.	.	.
cord-015021-pol2qm74	256	1	These	these	DT
cord-015021-pol2qm74	256	2	studies	study	NNS
cord-015021-pol2qm74	256	3	also	also	RB
cord-015021-pol2qm74	256	4	show	show	VBP
cord-015021-pol2qm74	256	5	that	that	IN
cord-015021-pol2qm74	256	6	LPS	LPS	NNP
cord-015021-pol2qm74	256	7	differences	difference	NNS
cord-015021-pol2qm74	256	8	measured	measure	VBN
cord-015021-pol2qm74	256	9	via	via	IN
cord-015021-pol2qm74	256	10	chromogenic	chromogenic	JJ
cord-015021-pol2qm74	256	11	LPS	LPS	NNP
cord-015021-pol2qm74	256	12	(	(	-LRB-
cord-015021-pol2qm74	256	13	C	C	NNP
cord-015021-pol2qm74	256	14	-	-	HYPH
cord-015021-pol2qm74	256	15	LAL	LAL	NNP
cord-015021-pol2qm74	256	16	)	)	-RRB-
cord-015021-pol2qm74	256	17	assay	assay	NN
cord-015021-pol2qm74	256	18	correlate	correlate	VBP
cord-015021-pol2qm74	256	19	with	with	IN
cord-015021-pol2qm74	256	20	LPS	LPS	NNP
cord-015021-pol2qm74	256	21	lethality	lethality	NN
cord-015021-pol2qm74	256	22	in	in	IN
cord-015021-pol2qm74	256	23	LPS	LPS	NNP
cord-015021-pol2qm74	256	24	-	-	HYPH
cord-015021-pol2qm74	256	25	sensitive	sensitive	JJ
cord-015021-pol2qm74	256	26	mice	mouse	NNS
cord-015021-pol2qm74	256	27	.	.	.
cord-015021-pol2qm74	257	1	Release	Release	NNP
cord-015021-pol2qm74	257	2	of	of	IN
cord-015021-pol2qm74	257	3	LPS	LPS	NNP
cord-015021-pol2qm74	257	4	was	be	VBD
cord-015021-pol2qm74	257	5	compared	compare	VBN
cord-015021-pol2qm74	257	6	to	to	IN
cord-015021-pol2qm74	257	7	changes	change	NNS
cord-015021-pol2qm74	257	8	in	in	IN
cord-015021-pol2qm74	257	9	CFUs	cfus	NN
cord-015021-pol2qm74	257	10	,	,	,
cord-015021-pol2qm74	257	11	cell	cell	NN
cord-015021-pol2qm74	257	12	mass	mass	NN
cord-015021-pol2qm74	257	13	,	,	,
cord-015021-pol2qm74	257	14	morphology	morphology	NN
cord-015021-pol2qm74	257	15	and	and	CC
cord-015021-pol2qm74	257	16	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	257	17	PBP	pbp	NN
cord-015021-pol2qm74	257	18	-	-	HYPH
cord-015021-pol2qm74	257	19	specificity	specificity	NN
cord-015021-pol2qm74	257	20	.	.	.
cord-015021-pol2qm74	258	1	Corresponding	correspond	VBG
cord-015021-pol2qm74	258	2	in	in	IN
cord-015021-pol2qm74	258	3	-	-	HYPH
cord-015021-pol2qm74	258	4	vivo	vivo	NN
cord-015021-pol2qm74	258	5	studies	study	NNS
cord-015021-pol2qm74	258	6	in	in	IN
cord-015021-pol2qm74	258	7	CD1	CD1	NNP
cord-015021-pol2qm74	258	8	mice	mouse	NNS
cord-015021-pol2qm74	258	9	against	against	IN
cord-015021-pol2qm74	259	1	s	s	NNP
cord-015021-pol2qm74	259	2	-	-	HYPH
cord-015021-pol2qm74	259	3	LPS	LPS	NNP
cord-015021-pol2qm74	259	4	P.	P.	NNP
cord-015021-pol2qm74	259	5	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	259	6	isolates	isolate	NNS
cord-015021-pol2qm74	259	7	show	show	VBP
cord-015021-pol2qm74	259	8	that	that	IN
cord-015021-pol2qm74	259	9	,	,	,
cord-015021-pol2qm74	259	10	despite	despite	IN
cord-015021-pol2qm74	259	11	equivalent	equivalent	JJ
cord-015021-pol2qm74	259	12	in	in	IN
cord-015021-pol2qm74	259	13	-	-	HYPH
cord-015021-pol2qm74	259	14	vitro	vitro	FW
cord-015021-pol2qm74	259	15	protection	protection	NN
cord-015021-pol2qm74	259	16	,	,	,
cord-015021-pol2qm74	259	17	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	259	18	efficacy	efficacy	NN
cord-015021-pol2qm74	259	19	in	in	IN
cord-015021-pol2qm74	259	20	mice	mouse	NNS
cord-015021-pol2qm74	259	21	differ	differ	VBP
cord-015021-pol2qm74	259	22	as	as	RB
cord-015021-pol2qm74	259	23	much	much	JJ
cord-015021-pol2qm74	259	24	as	as	IN
cord-015021-pol2qm74	259	25	100-to	100-to	CD
cord-015021-pol2qm74	259	26	lO00-fold	lo00-fold	CD
cord-015021-pol2qm74	259	27	.	.	.
cord-015021-pol2qm74	260	1	To	to	TO
cord-015021-pol2qm74	260	2	establish	establish	VB
cord-015021-pol2qm74	260	3	a	a	DT
cord-015021-pol2qm74	260	4	possible	possible	JJ
cord-015021-pol2qm74	260	5	in	in	IN
cord-015021-pol2qm74	260	6	-	-	HYPH
cord-015021-pol2qm74	260	7	vivo	vivo	NN
cord-015021-pol2qm74	260	8	role	role	NN
cord-015021-pol2qm74	260	9	for	for	IN
cord-015021-pol2qm74	260	10	antibiotic	antibiotic	NN
cord-015021-pol2qm74	260	11	-	-	HYPH
cord-015021-pol2qm74	260	12	induced	induce	VBN
cord-015021-pol2qm74	260	13	release	release	NN
cord-015021-pol2qm74	260	14	of	of	IN
cord-015021-pol2qm74	260	15	free	free	JJ
cord-015021-pol2qm74	260	16	LPS	LPS	NNP
cord-015021-pol2qm74	260	17	we	-PRON-	PRP
cord-015021-pol2qm74	260	18	compared	compare	VBD
cord-015021-pol2qm74	260	19	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	260	20	efficacy	efficacy	NN
cord-015021-pol2qm74	260	21	results	result	NNS
cord-015021-pol2qm74	260	22	in	in	IN
cord-015021-pol2qm74	260	23	mice	mouse	NNS
cord-015021-pol2qm74	260	24	challenged	challenge	VBN
cord-015021-pol2qm74	260	25	with	with	IN
cord-015021-pol2qm74	260	26	virulent	virulent	JJ
cord-015021-pol2qm74	260	27	parent	parent	NN
cord-015021-pol2qm74	260	28	s	s	POS
cord-015021-pol2qm74	260	29	-	-	HYPH
cord-015021-pol2qm74	260	30	LPS	LPS	NNP
cord-015021-pol2qm74	260	31	and	and	CC
cord-015021-pol2qm74	260	32	its	-PRON-	PRP$
cord-015021-pol2qm74	260	33	relatively	relatively	RB
cord-015021-pol2qm74	260	34	avirulent	avirulent	NN
cord-015021-pol2qm74	260	35	r	r	NNP
cord-015021-pol2qm74	260	36	-	-	HYPH
cord-015021-pol2qm74	260	37	LPS	LPS	NNP
cord-015021-pol2qm74	260	38	mutant	mutant	NN
cord-015021-pol2qm74	260	39	(	(	-LRB-
cord-015021-pol2qm74	260	40	lacking	lack	VBG
cord-015021-pol2qm74	260	41	only	only	RB
cord-015021-pol2qm74	260	42	its	-PRON-	PRP$
cord-015021-pol2qm74	260	43	0	0	CD
cord-015021-pol2qm74	260	44	side	side	NN
cord-015021-pol2qm74	260	45	chain	chain	NN
cord-015021-pol2qm74	260	46	)	)	-RRB-
cord-015021-pol2qm74	261	1	P.	P.	NNP
cord-015021-pol2qm74	261	2	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	261	3	isolates	isolate	NNS
cord-015021-pol2qm74	261	4	.	.	.
cord-015021-pol2qm74	262	1	Results	result	NNS
cord-015021-pol2qm74	262	2	show	show	VBP
cord-015021-pol2qm74	262	3	the	the	DT
cord-015021-pol2qm74	262	4	relevance	relevance	NN
cord-015021-pol2qm74	262	5	of	of	IN
cord-015021-pol2qm74	262	6	quantity	quantity	NN
cord-015021-pol2qm74	262	7	and	and	CC
cord-015021-pol2qm74	262	8	physiochemical	physiochemical	JJ
cord-015021-pol2qm74	262	9	composition	composition	NN
cord-015021-pol2qm74	262	10	(	(	-LRB-
cord-015021-pol2qm74	262	11	bioreactivity	bioreactivity	NNP
cord-015021-pol2qm74	262	12	)	)	-RRB-
cord-015021-pol2qm74	262	13	of	of	IN
cord-015021-pol2qm74	262	14	free	free	JJ
cord-015021-pol2qm74	262	15	LPS	lp	NNS
cord-015021-pol2qm74	262	16	to	to	IN
cord-015021-pol2qm74	262	17	virulence	virulence	NN
cord-015021-pol2qm74	262	18	and	and	CC
cord-015021-pol2qm74	262	19	in	in	IN
cord-015021-pol2qm74	262	20	-	-	HYPH
cord-015021-pol2qm74	262	21	vivo	vivo	NN
cord-015021-pol2qm74	262	22	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	262	23	efficacy	efficacy	NN
cord-015021-pol2qm74	262	24	.	.	.
cord-015021-pol2qm74	263	1	In	in	IN
cord-015021-pol2qm74	263	2	other	other	JJ
cord-015021-pol2qm74	263	3	in	in	IN
cord-015021-pol2qm74	263	4	-	-	HYPH
cord-015021-pol2qm74	263	5	vivo	vivo	NN
cord-015021-pol2qm74	263	6	studies	study	NNS
cord-015021-pol2qm74	263	7	chemical	chemical	NN
cord-015021-pol2qm74	263	8	agents	agent	NNS
cord-015021-pol2qm74	263	9	that	that	WDT
cord-015021-pol2qm74	263	10	destroy	destroy	VBP
cord-015021-pol2qm74	263	11	cells	cell	NNS
cord-015021-pol2qm74	263	12	(	(	-LRB-
cord-015021-pol2qm74	263	13	m~	m~	XX
cord-015021-pol2qm74	263	14	)	)	-RRB-
cord-015021-pol2qm74	263	15	which	which	WDT
cord-015021-pol2qm74	263	16	mediate	mediate	VBP
cord-015021-pol2qm74	263	17	LPS	LPS	NNP
cord-015021-pol2qm74	263	18	lethality	lethality	NN
cord-015021-pol2qm74	263	19	in	in	IN
cord-015021-pol2qm74	263	20	-	-	HYPH
cord-015021-pol2qm74	263	21	vivo	vivo	NN
cord-015021-pol2qm74	263	22	were	be	VBD
cord-015021-pol2qm74	263	23	used	use	VBN
cord-015021-pol2qm74	263	24	to	to	TO
cord-015021-pol2qm74	263	25	pretreat	pretreat	VB
cord-015021-pol2qm74	263	26	mice	mouse	NNS
cord-015021-pol2qm74	263	27	prior	prior	RB
cord-015021-pol2qm74	263	28	to	to	IN
cord-015021-pol2qm74	263	29	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	263	30	therapy	therapy	NN
cord-015021-pol2qm74	263	31	and	and	CC
cord-015021-pol2qm74	263	32	bacterial	bacterial	JJ
cord-015021-pol2qm74	263	33	challenge	challenge	NN
cord-015021-pol2qm74	263	34	with	with	IN
cord-015021-pol2qm74	263	35	wild	wild	JJ
cord-015021-pol2qm74	263	36	type	type	NN
cord-015021-pol2qm74	263	37	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	263	38	.	.	.
cord-015021-pol2qm74	264	1	We	-PRON-	PRP
cord-015021-pol2qm74	264	2	conclude	conclude	VBP
cord-015021-pol2qm74	264	3	that	that	IN
cord-015021-pol2qm74	264	4	circumstances	circumstance	NNS
cord-015021-pol2qm74	264	5	in	in	IN
cord-015021-pol2qm74	264	6	which	which	WDT
cord-015021-pol2qm74	264	7	antibiotic	antibiotic	NN
cord-015021-pol2qm74	264	8	-	-	HYPH
cord-015021-pol2qm74	264	9	induced	induce	VBN
cord-015021-pol2qm74	264	10	filamentation	filamentation	NN
cord-015021-pol2qm74	264	11	occurs	occur	VBZ
cord-015021-pol2qm74	264	12	are	be	VBP
cord-015021-pol2qm74	264	13	also	also	RB
cord-015021-pol2qm74	264	14	conditions	condition	NNS
cord-015021-pol2qm74	264	15	that	that	WDT
cord-015021-pol2qm74	264	16	yield	yield	VBP
cord-015021-pol2qm74	264	17	excessive	excessive	JJ
cord-015021-pol2qm74	264	18	LPS	LPS	NNP
cord-015021-pol2qm74	264	19	release	release	NN
cord-015021-pol2qm74	264	20	,	,	,
cord-015021-pol2qm74	264	21	the	the	DT
cord-015021-pol2qm74	264	22	in	in	IN
cord-015021-pol2qm74	264	23	-	-	HYPH
cord-015021-pol2qm74	264	24	vivo	vivo	NN
cord-015021-pol2qm74	264	25	effects	effect	NNS
cord-015021-pol2qm74	264	26	of	of	IN
cord-015021-pol2qm74	264	27	which	which	WDT
cord-015021-pol2qm74	264	28	are	be	VBP
cord-015021-pol2qm74	264	29	shown	show	VBN
cord-015021-pol2qm74	264	30	through	through	IN
cord-015021-pol2qm74	264	31	the	the	DT
cord-015021-pol2qm74	264	32	requirement	requirement	NN
cord-015021-pol2qm74	264	33	of	of	IN
cord-015021-pol2qm74	264	34	larger	large	JJR
cord-015021-pol2qm74	264	35	amounts	amount	NNS
cord-015021-pol2qm74	264	36	of	of	IN
cord-015021-pol2qm74	264	37	antibiotic	antibiotic	NN
cord-015021-pol2qm74	264	38	to	to	TO
cord-015021-pol2qm74	264	39	afford	afford	VB
cord-015021-pol2qm74	264	40	equivalent	equivalent	JJ
cord-015021-pol2qm74	264	41	protection	protection	NN
cord-015021-pol2qm74	264	42	.	.	.
cord-015021-pol2qm74	265	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	265	2	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	265	3	have	have	VBP
cord-015021-pol2qm74	265	4	been	be	VBN
cord-015021-pol2qm74	265	5	reported	report	VBN
cord-015021-pol2qm74	265	6	to	to	TO
cord-015021-pol2qm74	265	7	play	play	VB
cord-015021-pol2qm74	265	8	a	a	DT
cord-015021-pol2qm74	265	9	significant	significant	JJ
cord-015021-pol2qm74	265	10	role	role	NN
cord-015021-pol2qm74	265	11	in	in	IN
cord-015021-pol2qm74	265	12	the	the	DT
cord-015021-pol2qm74	265	13	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	265	14	of	of	IN
cord-015021-pol2qm74	265	15	Gram	Gram	NNP
cord-015021-pol2qm74	265	16	negative	negative	JJ
cord-015021-pol2qm74	265	17	sepsis	sepsis	NN
cord-015021-pol2qm74	265	18	by	by	IN
cord-015021-pol2qm74	265	19	their	-PRON-	PRP$
cord-015021-pol2qm74	265	20	interaction	interaction	NN
cord-015021-pol2qm74	265	21	with	with	IN
cord-015021-pol2qm74	265	22	,	,	,
cord-015021-pol2qm74	265	23	and	and	CC
cord-015021-pol2qm74	265	24	stimulation	stimulation	NN
cord-015021-pol2qm74	265	25	of	of	IN
cord-015021-pol2qm74	265	26	,	,	,
cord-015021-pol2qm74	265	27	host	host	VBP
cord-015021-pol2qm74	265	28	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	265	29	mediator	mediator	NN
cord-015021-pol2qm74	265	30	cells	cell	NNS
cord-015021-pol2qm74	265	31	to	to	TO
cord-015021-pol2qm74	265	32	produce	produce	VB
cord-015021-pol2qm74	265	33	cytokines	cytokine	NNS
cord-015021-pol2qm74	265	34	,	,	,
cord-015021-pol2qm74	265	35	biologically	biologically	RB
cord-015021-pol2qm74	265	36	active	active	JJ
cord-015021-pol2qm74	265	37	lipid	lipid	NN
cord-015021-pol2qm74	265	38	intermediates	intermediate	NNS
cord-015021-pol2qm74	265	39	,	,	,
cord-015021-pol2qm74	265	40	and	and	CC
cord-015021-pol2qm74	265	41	procoagulant	procoagulant	NN
cord-015021-pol2qm74	265	42	activity	activity	NN
cord-015021-pol2qm74	265	43	(	(	-LRB-
cord-015021-pol2qm74	265	44	TFa	TFa	NNP
cord-015021-pol2qm74	265	45	)	)	-RRB-
cord-015021-pol2qm74	265	46	.	.	.
cord-015021-pol2qm74	266	1	Although	although	IN
cord-015021-pol2qm74	266	2	both	both	DT
cord-015021-pol2qm74	266	3	microbe	microbe	NN
cord-015021-pol2qm74	266	4	-	-	HYPH
cord-015021-pol2qm74	266	5	associated	associate	VBN
cord-015021-pol2qm74	266	6	and	and	CC
cord-015021-pol2qm74	266	7	free	free	JJ
cord-015021-pol2qm74	266	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	266	9	are	be	VBP
cord-015021-pol2qm74	266	10	capable	capable	JJ
cord-015021-pol2qm74	266	11	of	of	IN
cord-015021-pol2qm74	266	12	stimulating	stimulate	VBG
cord-015021-pol2qm74	266	13	mediator	mediator	NN
cord-015021-pol2qm74	266	14	production	production	NN
cord-015021-pol2qm74	266	15	,	,	,
cord-015021-pol2qm74	266	16	studies	study	NNS
cord-015021-pol2qm74	266	17	from	from	IN
cord-015021-pol2qm74	266	18	our	-PRON-	PRP$
cord-015021-pol2qm74	266	19	laboratory	laboratory	NN
cord-015021-pol2qm74	266	20	suggest	suggest	VBP
cord-015021-pol2qm74	266	21	that	that	IN
cord-015021-pol2qm74	266	22	free	free	JJ
cord-015021-pol2qm74	266	23	endotoxin	endotoxin	NN
cord-015021-pol2qm74	266	24	may	may	MD
cord-015021-pol2qm74	266	25	be	be	VB
cord-015021-pol2qm74	266	26	the	the	DT
cord-015021-pol2qm74	266	27	more	more	RBR
cord-015021-pol2qm74	266	28	potent	potent	JJ
cord-015021-pol2qm74	266	29	stimulus	stimulus	NN
cord-015021-pol2qm74	266	30	for	for	IN
cord-015021-pol2qm74	266	31	TNF	TNF	NNP
cord-015021-pol2qm74	266	32	and	and	CC
cord-015021-pol2qm74	266	33	TFa	TFa	NNP
cord-015021-pol2qm74	266	34	.	.	.
cord-015021-pol2qm74	267	1	Further	further	RB
cord-015021-pol2qm74	267	2	,	,	,
cord-015021-pol2qm74	267	3	our	-PRON-	PRP$
cord-015021-pol2qm74	267	4	studies	study	NNS
cord-015021-pol2qm74	267	5	suggest	suggest	VBP
cord-015021-pol2qm74	267	6	that	that	IN
cord-015021-pol2qm74	267	7	the	the	DT
cord-015021-pol2qm74	267	8	majority	majority	NN
cord-015021-pol2qm74	267	9	of	of	IN
cord-015021-pol2qm74	267	10	the	the	DT
cord-015021-pol2qm74	267	11	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	267	12	activity	activity	NN
cord-015021-pol2qm74	267	13	released	release	VBN
cord-015021-pol2qm74	267	14	from	from	IN
cord-015021-pol2qm74	267	15	antibiotictreated	antibiotictreated	JJ
cord-015021-pol2qm74	267	16	E.	E.	NNP
cord-015021-pol2qm74	267	17	coli	coli	VBZ
cord-015021-pol2qm74	267	18	coisolates	coisolate	NNS
cord-015021-pol2qm74	267	19	with	with	IN
cord-015021-pol2qm74	267	20	LPS	lp	NNS
cord-015021-pol2qm74	267	21	by	by	IN
cord-015021-pol2qm74	267	22	two	two	CD
cord-015021-pol2qm74	267	23	different	different	JJ
cord-015021-pol2qm74	267	24	fractionation	fractionation	NN
cord-015021-pol2qm74	267	25	techniques	technique	NNS
cord-015021-pol2qm74	267	26	.	.	.
cord-015021-pol2qm74	268	1	To	to	TO
cord-015021-pol2qm74	268	2	assess	assess	VB
cord-015021-pol2qm74	268	3	whether	whether	IN
cord-015021-pol2qm74	268	4	actions	action	NNS
cord-015021-pol2qm74	268	5	of	of	IN
cord-015021-pol2qm74	268	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	268	7	directly	directly	RB
cord-015021-pol2qm74	268	8	contribute	contribute	VBP
cord-015021-pol2qm74	268	9	to	to	IN
cord-015021-pol2qm74	268	10	lethality	lethality	NN
cord-015021-pol2qm74	268	11	in	in	IN
cord-015021-pol2qm74	268	12	Gram	Gram	NNP
cord-015021-pol2qm74	268	13	negative	negative	JJ
cord-015021-pol2qm74	268	14	sepsis	sepsis	NN
cord-015021-pol2qm74	268	15	,	,	,
cord-015021-pol2qm74	268	16	an	an	DT
cord-015021-pol2qm74	268	17	experimental	experimental	JJ
cord-015021-pol2qm74	268	18	model	model	NN
cord-015021-pol2qm74	268	19	was	be	VBD
cord-015021-pol2qm74	268	20	developed	develop	VBN
cord-015021-pol2qm74	268	21	in	in	IN
cord-015021-pol2qm74	268	22	which	which	WDT
cord-015021-pol2qm74	268	23	mice	mouse	NNS
cord-015021-pol2qm74	268	24	were	be	VBD
cord-015021-pol2qm74	268	25	made	make	VBN
cord-015021-pol2qm74	268	26	hypersusceptihle	hypersusceptihle	NN
cord-015021-pol2qm74	268	27	to	to	IN
cord-015021-pol2qm74	268	28	the	the	DT
cord-015021-pol2qm74	268	29	lethal	lethal	JJ
cord-015021-pol2qm74	268	30	effects	effect	NNS
cord-015021-pol2qm74	268	31	of	of	IN
cord-015021-pol2qm74	268	32	endotoxin	endotoxin	NN
cord-015021-pol2qm74	268	33	by	by	IN
cord-015021-pol2qm74	268	34	treatment	treatment	NN
cord-015021-pol2qm74	268	35	with	with	IN
cord-015021-pol2qm74	268	36	D	d	NN
cord-015021-pol2qm74	268	37	-	-	HYPH
cord-015021-pol2qm74	268	38	galactosamine	galactosamine	NN
cord-015021-pol2qm74	268	39	(	(	-LRB-
cord-015021-pol2qm74	268	40	DgalN	DgalN	NNP
cord-015021-pol2qm74	268	41	)	)	-RRB-
cord-015021-pol2qm74	268	42	.	.	.
cord-015021-pol2qm74	269	1	Challenge	challenge	NN
cord-015021-pol2qm74	269	2	of	of	IN
cord-015021-pol2qm74	269	3	CF-1	CF-1	NNP
cord-015021-pol2qm74	269	4	DgalN	DgalN	NNP
cord-015021-pol2qm74	269	5	-	-	HYPH
cord-015021-pol2qm74	269	6	treated	treat	VBN
cord-015021-pol2qm74	269	7	mice	mouse	NNS
cord-015021-pol2qm74	269	8	with	with	IN
cord-015021-pol2qm74	269	9	E.	E.	NNP
cord-015021-pol2qm74	269	10	coli	coli	NNS
cord-015021-pol2qm74	270	1	Olll	Olll	NNP
cord-015021-pol2qm74	270	2	:	:	:
cord-015021-pol2qm74	270	3	B4	B4	NNP
cord-015021-pol2qm74	270	4	resulted	result	VBD
cord-015021-pol2qm74	270	5	in	in	IN
cord-015021-pol2qm74	270	6	an	an	DT
cord-015021-pol2qm74	270	7	LDs0	lds0	NN
cord-015021-pol2qm74	270	8	of	of	IN
cord-015021-pol2qm74	270	9	approximately	approximately	RB
cord-015021-pol2qm74	270	10	2.5	2.5	CD
cord-015021-pol2qm74	270	11	x	x	SYM
cord-015021-pol2qm74	270	12	104	104	CD
cord-015021-pol2qm74	270	13	CFU	CFU	NNP
cord-015021-pol2qm74	270	14	.	.	.
cord-015021-pol2qm74	271	1	Resolution	resolution	NN
cord-015021-pol2qm74	271	2	of	of	IN
cord-015021-pol2qm74	271	3	the	the	DT
cord-015021-pol2qm74	271	4	peritonitis	peritonitis	NN
cord-015021-pol2qm74	271	5	and	and	CC
cord-015021-pol2qm74	271	6	bacteremia	bacteremia	NN
cord-015021-pol2qm74	271	7	by	by	IN
cord-015021-pol2qm74	271	8	treatment	treatment	NN
cord-015021-pol2qm74	271	9	with	with	IN
cord-015021-pol2qm74	271	10	cell	cell	NN
cord-015021-pol2qm74	271	11	wall	wall	NN
cord-015021-pol2qm74	271	12	-	-	HYPH
cord-015021-pol2qm74	271	13	active	active	JJ
cord-015021-pol2qm74	271	14	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	271	15	resulted	result	VBD
cord-015021-pol2qm74	271	16	in	in	IN
cord-015021-pol2qm74	271	17	an	an	DT
cord-015021-pol2qm74	271	18	increase	increase	NN
cord-015021-pol2qm74	271	19	in	in	IN
cord-015021-pol2qm74	271	20	the	the	DT
cord-015021-pol2qm74	271	21	LDso	LDso	NNP
cord-015021-pol2qm74	271	22	.	.	.
cord-015021-pol2qm74	272	1	Ceftazidime	Ceftazidime	NNP
cord-015021-pol2qm74	272	2	and	and	CC
cord-015021-pol2qm74	272	3	imipenem	imipenem	NNP
cord-015021-pol2qm74	272	4	,	,	,
cord-015021-pol2qm74	272	5	which	which	WDT
cord-015021-pol2qm74	272	6	differ	differ	VBP
cord-015021-pol2qm74	272	7	in	in	IN
cord-015021-pol2qm74	272	8	their	-PRON-	PRP$
cord-015021-pol2qm74	272	9	mechanism	mechanism	NN
cord-015021-pol2qm74	272	10	of	of	IN
cord-015021-pol2qm74	272	11	action	action	NN
cord-015021-pol2qm74	272	12	and	and	CC
cord-015021-pol2qm74	272	13	in	in	IN
cord-015021-pol2qm74	272	14	their	-PRON-	PRP$
cord-015021-pol2qm74	272	15	capacity	capacity	NN
cord-015021-pol2qm74	272	16	to	to	TO
cord-015021-pol2qm74	272	17	effect	effect	VB
cord-015021-pol2qm74	272	18	endotoxin	endotoxin	NN
cord-015021-pol2qm74	272	19	release	release	NN
cord-015021-pol2qm74	272	20	in	in	IN
cord-015021-pol2qm74	272	21	vitro	vitro	FW
cord-015021-pol2qm74	272	22	,	,	,
cord-015021-pol2qm74	272	23	also	also	RB
cord-015021-pol2qm74	272	24	differed	differ	VBD
cord-015021-pol2qm74	272	25	in	in	IN
cord-015021-pol2qm74	272	26	their	-PRON-	PRP$
cord-015021-pol2qm74	272	27	in	in	IN
cord-015021-pol2qm74	272	28	vivo	vivo	NN
cord-015021-pol2qm74	272	29	capacity	capacity	NN
cord-015021-pol2qm74	272	30	to	to	TO
cord-015021-pol2qm74	272	31	provide	provide	VB
cord-015021-pol2qm74	272	32	chemotherapeutic	chemotherapeutic	JJ
cord-015021-pol2qm74	272	33	protection	protection	NN
cord-015021-pol2qm74	272	34	(	(	-LRB-
cord-015021-pol2qm74	272	35	3	3	CD
cord-015021-pol2qm74	272	36	fold	fold	NN
cord-015021-pol2qm74	272	37	vs	vs	IN
cord-015021-pol2qm74	272	38	8	8	CD
cord-015021-pol2qm74	272	39	fold	fold	NN
cord-015021-pol2qm74	272	40	respectively	respectively	RB
cord-015021-pol2qm74	272	41	,	,	,
cord-015021-pol2qm74	272	42	p	p	NN
cord-015021-pol2qm74	272	43	<	<	XX
cord-015021-pol2qm74	272	44	.01	.01	NFP
cord-015021-pol2qm74	272	45	)	)	-RRB-
cord-015021-pol2qm74	272	46	.	.	.
cord-015021-pol2qm74	273	1	Parallel	parallel	JJ
cord-015021-pol2qm74	273	2	studies	study	NNS
cord-015021-pol2qm74	273	3	with	with	IN
cord-015021-pol2qm74	273	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	273	5	hyporesponsive	hyporesponsive	NNP
cord-015021-pol2qm74	274	1	C3H	C3H	NNP
cord-015021-pol2qm74	274	2	/	/	SYM
cord-015021-pol2qm74	274	3	HeJ	HeJ	NNP
cord-015021-pol2qm74	274	4	mice	mouse	NNS
cord-015021-pol2qm74	274	5	indicate	indicate	VBP
cord-015021-pol2qm74	274	6	significantly	significantly	RB
cord-015021-pol2qm74	274	7	greater	great	JJR
cord-015021-pol2qm74	274	8	levels	level	NNS
cord-015021-pol2qm74	274	9	of	of	IN
cord-015021-pol2qm74	274	10	protection	protection	NN
cord-015021-pol2qm74	274	11	with	with	IN
cord-015021-pol2qm74	274	12	imipenem	imipenem	NNP
cord-015021-pol2qm74	274	13	(	(	-LRB-
cord-015021-pol2qm74	274	14	>	>	NFP
cord-015021-pol2qm74	274	15	80	80	CD
cord-015021-pol2qm74	274	16	fold	fold	NN
cord-015021-pol2qm74	274	17	vs	vs	IN
cord-015021-pol2qm74	274	18	saline	saline	NN
cord-015021-pol2qm74	274	19	controls	control	NNS
cord-015021-pol2qm74	274	20	)	)	-RRB-
cord-015021-pol2qm74	274	21	.	.	.
cord-015021-pol2qm74	275	1	Collectively	collectively	RB
cord-015021-pol2qm74	275	2	these	these	DT
cord-015021-pol2qm74	275	3	data	datum	NNS
cord-015021-pol2qm74	275	4	suggest	suggest	VBP
cord-015021-pol2qm74	275	5	that	that	IN
cord-015021-pol2qm74	275	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	275	7	may	may	MD
cord-015021-pol2qm74	275	8	contribute	contribute	VB
cord-015021-pol2qm74	275	9	directly	directly	RB
cord-015021-pol2qm74	275	10	to	to	IN
cord-015021-pol2qm74	275	11	the	the	DT
cord-015021-pol2qm74	275	12	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	275	13	of	of	IN
cord-015021-pol2qm74	275	14	experimental	experimental	JJ
cord-015021-pol2qm74	275	15	Gram	Gram	NNP
cord-015021-pol2qm74	275	16	negative	negative	JJ
cord-015021-pol2qm74	275	17	sepsis	sepsis	NN
cord-015021-pol2qm74	275	18	.	.	.
cord-015021-pol2qm74	276	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	276	2	lipopolysaccharides	lipopolysaccharide	NNS
cord-015021-pol2qm74	276	3	(	(	-LRB-
cord-015021-pol2qm74	276	4	LPS	LPS	NNP
cord-015021-pol2qm74	276	5	)	)	-RRB-
cord-015021-pol2qm74	276	6	are	be	VBP
cord-015021-pol2qm74	276	7	the	the	DT
cord-015021-pol2qm74	276	8	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	276	9	of	of	IN
cord-015021-pol2qm74	276	10	gram	gram	NN
cord-015021-pol2qm74	276	11	-	-	HYPH
cord-015021-pol2qm74	276	12	negative	negative	JJ
cord-015021-pol2qm74	276	13	bacteria	bacteria	NNS
cord-015021-pol2qm74	276	14	and	and	CC
cord-015021-pol2qm74	276	15	represent	represent	VBP
cord-015021-pol2qm74	276	16	their	-PRON-	PRP$
cord-015021-pol2qm74	276	17	major	major	JJ
cord-015021-pol2qm74	276	18	surface	surface	NN
cord-015021-pol2qm74	276	19	antigens	antigen	NNS
cord-015021-pol2qm74	276	20	.	.	.
cord-015021-pol2qm74	277	1	LPS	LPS	NNP
cord-015021-pol2qm74	277	2	is	be	VBZ
cord-015021-pol2qm74	277	3	made	make	VBN
cord-015021-pol2qm74	277	4	up	up	RP
cord-015021-pol2qm74	277	5	of	of	IN
cord-015021-pol2qm74	277	6	three	three	CD
cord-015021-pol2qm74	277	7	chemically	chemically	RB
cord-015021-pol2qm74	277	8	,	,	,
cord-015021-pol2qm74	277	9	biologically	biologically	RB
cord-015021-pol2qm74	277	10	and	and	CC
cord-015021-pol2qm74	277	11	genetically	genetically	RB
cord-015021-pol2qm74	277	12	disctinct	disctinct	JJ
cord-015021-pol2qm74	277	13	regions	region	NNS
cord-015021-pol2qm74	277	14	,	,	,
cord-015021-pol2qm74	277	15	i.e	i.e	XX
cord-015021-pol2qm74	277	16	,	,	,
cord-015021-pol2qm74	277	17	the	the	DT
cord-015021-pol2qm74	277	18	O	o	NN
cord-015021-pol2qm74	277	19	-	-	HYPH
cord-015021-pol2qm74	277	20	chain	chain	NN
cord-015021-pol2qm74	277	21	,	,	,
cord-015021-pol2qm74	277	22	the	the	DT
cord-015021-pol2qm74	277	23	core	core	NN
cord-015021-pol2qm74	277	24	region	region	NN
cord-015021-pol2qm74	277	25	and	and	CC
cord-015021-pol2qm74	277	26	the	the	DT
cord-015021-pol2qm74	277	27	lipid	lipid	NN
cord-015021-pol2qm74	277	28	A	a	DT
cord-015021-pol2qm74	277	29	moiety	moiety	NN
cord-015021-pol2qm74	277	30	whereby	whereby	WRB
cord-015021-pol2qm74	277	31	the	the	DT
cord-015021-pol2qm74	277	32	latter	latter	JJ
cord-015021-pol2qm74	277	33	represents	represent	VBZ
cord-015021-pol2qm74	277	34	the	the	DT
cord-015021-pol2qm74	277	35	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	277	36	center	center	NN
cord-015021-pol2qm74	277	37	.	.	.
cord-015021-pol2qm74	278	1	It	-PRON-	PRP
cord-015021-pol2qm74	278	2	is	be	VBZ
cord-015021-pol2qm74	278	3	our	-PRON-	PRP$
cord-015021-pol2qm74	278	4	current	current	JJ
cord-015021-pol2qm74	278	5	understanding	understanding	NN
cord-015021-pol2qm74	278	6	that	that	IN
cord-015021-pol2qm74	278	7	LPS	LPS	NNP
cord-015021-pol2qm74	278	8	is	be	VBZ
cord-015021-pol2qm74	278	9	responsible	responsible	JJ
cord-015021-pol2qm74	278	10	for	for	IN
cord-015021-pol2qm74	278	11	many	many	JJ
cord-015021-pol2qm74	278	12	of	of	IN
cord-015021-pol2qm74	278	13	the	the	DT
cord-015021-pol2qm74	278	14	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	278	15	events	event	NNS
cord-015021-pol2qm74	278	16	observed	observe	VBN
cord-015021-pol2qm74	278	17	during	during	IN
cord-015021-pol2qm74	278	18	gramnegative	gramnegative	JJ
cord-015021-pol2qm74	278	19	infections	infection	NNS
cord-015021-pol2qm74	278	20	and	and	CC
cord-015021-pol2qm74	278	21	that	that	IN
cord-015021-pol2qm74	278	22	one	one	CD
cord-015021-pol2qm74	278	23	of	of	IN
cord-015021-pol2qm74	278	24	the	the	DT
cord-015021-pol2qm74	278	25	major	major	JJ
cord-015021-pol2qm74	278	26	mechanisms	mechanism	NNS
cord-015021-pol2qm74	278	27	leading	lead	VBG
cord-015021-pol2qm74	278	28	to	to	IN
cord-015021-pol2qm74	278	29	shock	shock	NN
cord-015021-pol2qm74	278	30	and	and	CC
cord-015021-pol2qm74	278	31	death	death	NN
cord-015021-pol2qm74	278	32	is	be	VBZ
cord-015021-pol2qm74	278	33	the	the	DT
cord-015021-pol2qm74	278	34	LPS	LPS	NNP
cord-015021-pol2qm74	278	35	-	-	HYPH
cord-015021-pol2qm74	278	36	induced	induce	VBN
cord-015021-pol2qm74	278	37	activation	activation	NN
cord-015021-pol2qm74	278	38	of	of	IN
cord-015021-pol2qm74	278	39	macrophages	macrophage	NNS
cord-015021-pol2qm74	278	40	resulting	result	VBG
cord-015021-pol2qm74	278	41	in	in	IN
cord-015021-pol2qm74	278	42	the	the	DT
cord-015021-pol2qm74	278	43	production	production	NN
cord-015021-pol2qm74	278	44	and	and	CC
cord-015021-pol2qm74	278	45	release	release	NN
cord-015021-pol2qm74	278	46	of	of	IN
cord-015021-pol2qm74	278	47	lipid	lipid	NN
cord-015021-pol2qm74	278	48	and	and	CC
cord-015021-pol2qm74	278	49	peptide	peptide	NN
cord-015021-pol2qm74	278	50	mediators	mediator	NNS
cord-015021-pol2qm74	278	51	,	,	,
cord-015021-pol2qm74	278	52	among	among	IN
cord-015021-pol2qm74	278	53	which	which	WDT
cord-015021-pol2qm74	278	54	tumor	tumor	NN
cord-015021-pol2qm74	278	55	necrosis	necrosis	NN
cord-015021-pol2qm74	278	56	factor	factor	NN
cord-015021-pol2qm74	278	57	seems	seem	VBZ
cord-015021-pol2qm74	278	58	to	to	TO
cord-015021-pol2qm74	278	59	be	be	VB
cord-015021-pol2qm74	278	60	the	the	DT
cord-015021-pol2qm74	278	61	most	most	RBS
cord-015021-pol2qm74	278	62	important	important	JJ
cord-015021-pol2qm74	278	63	.	.	.
cord-015021-pol2qm74	279	1	Therefore	therefore	RB
cord-015021-pol2qm74	279	2	,	,	,
cord-015021-pol2qm74	279	3	in	in	IN
cord-015021-pol2qm74	279	4	the	the	DT
cord-015021-pol2qm74	279	5	fight	fight	NN
cord-015021-pol2qm74	279	6	against	against	IN
cord-015021-pol2qm74	279	7	the	the	DT
cord-015021-pol2qm74	279	8	lethal	lethal	JJ
cord-015021-pol2qm74	279	9	outcome	outcome	NN
cord-015021-pol2qm74	279	10	of	of	IN
cord-015021-pol2qm74	279	11	gram	gram	JJ
cord-015021-pol2qm74	279	12	-	-	HYPH
cord-015021-pol2qm74	279	13	negative	negative	JJ
cord-015021-pol2qm74	279	14	infections	infection	NNS
cord-015021-pol2qm74	279	15	,	,	,
cord-015021-pol2qm74	279	16	modern	modern	JJ
cord-015021-pol2qm74	279	17	strategies	strategy	NNS
cord-015021-pol2qm74	279	18	,	,	,
cord-015021-pol2qm74	279	19	in	in	IN
cord-015021-pol2qm74	279	20	addition	addition	NN
cord-015021-pol2qm74	279	21	to	to	IN
cord-015021-pol2qm74	279	22	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	279	23	treatment	treatment	NN
cord-015021-pol2qm74	279	24	,	,	,
cord-015021-pol2qm74	279	25	aim	aim	VB
cord-015021-pol2qm74	279	26	at	at	IN
cord-015021-pol2qm74	279	27	i	i	NN
cord-015021-pol2qm74	279	28	)	)	-RRB-
cord-015021-pol2qm74	280	1	the	the	DT
cord-015021-pol2qm74	280	2	neutralization	neutralization	NN
cord-015021-pol2qm74	280	3	of	of	IN
cord-015021-pol2qm74	280	4	tumor	tumor	NN
cord-015021-pol2qm74	280	5	necrosis	necrosis	NN
cord-015021-pol2qm74	280	6	factor	factor	NN
cord-015021-pol2qm74	280	7	,	,	,
cord-015021-pol2qm74	280	8	ii	ii	NN
cord-015021-pol2qm74	280	9	)	)	-RRB-
cord-015021-pol2qm74	281	1	the	the	DT
cord-015021-pol2qm74	281	2	inhibition	inhibition	NN
cord-015021-pol2qm74	281	3	of	of	IN
cord-015021-pol2qm74	281	4	the	the	DT
cord-015021-pol2qm74	281	5	production	production	NN
cord-015021-pol2qm74	281	6	of	of	IN
cord-015021-pol2qm74	281	7	tumor	tumor	NN
cord-015021-pol2qm74	281	8	necrosis	necrosis	NN
cord-015021-pol2qm74	281	9	factor	factor	NN
cord-015021-pol2qm74	281	10	or	or	CC
cord-015021-pol2qm74	281	11	iii	iii	NN
cord-015021-pol2qm74	281	12	)	)	-RRB-
cord-015021-pol2qm74	282	1	the	the	DT
cord-015021-pol2qm74	282	2	neutralization	neutralization	NN
cord-015021-pol2qm74	282	3	of	of	IN
cord-015021-pol2qm74	282	4	the	the	DT
cord-015021-pol2qm74	282	5	activation	activation	NN
cord-015021-pol2qm74	282	6	potential	potential	NN
cord-015021-pol2qm74	282	7	of	of	IN
cord-015021-pol2qm74	282	8	LPS	LPS	NNP
cord-015021-pol2qm74	282	9	for	for	IN
cord-015021-pol2qm74	282	10	macrophages	macrophage	NNS
cord-015021-pol2qm74	282	11	by	by	IN
cord-015021-pol2qm74	282	12	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	282	13	,	,	,
cord-015021-pol2qm74	282	14	preferably	preferably	RB
cord-015021-pol2qm74	282	15	human	human	JJ
cord-015021-pol2qm74	282	16	antibodies	antibody	NNS
cord-015021-pol2qm74	282	17	.	.	.
cord-015021-pol2qm74	283	1	The	the	DT
cord-015021-pol2qm74	283	2	latter	latter	JJ
cord-015021-pol2qm74	283	3	approach	approach	NN
cord-015021-pol2qm74	283	4	,	,	,
cord-015021-pol2qm74	283	5	to	to	TO
cord-015021-pol2qm74	283	6	be	be	VB
cord-015021-pol2qm74	283	7	effective	effective	JJ
cord-015021-pol2qm74	283	8	against	against	IN
cord-015021-pol2qm74	283	9	a	a	DT
cord-015021-pol2qm74	283	10	broad	broad	JJ
cord-015021-pol2qm74	283	11	spectrum	spectrum	NN
cord-015021-pol2qm74	283	12	of	of	IN
cord-015021-pol2qm74	283	13	gram	gram	NN
cord-015021-pol2qm74	283	14	-	-	HYPH
cord-015021-pol2qm74	283	15	negatives	negative	NNS
cord-015021-pol2qm74	283	16	,	,	,
cord-015021-pol2qm74	283	17	must	must	MD
cord-015021-pol2qm74	283	18	be	be	VB
cord-015021-pol2qm74	283	19	directed	direct	VBN
cord-015021-pol2qm74	283	20	against	against	IN
cord-015021-pol2qm74	283	21	common	common	JJ
cord-015021-pol2qm74	283	22	structures	structure	NNS
cord-015021-pol2qm74	283	23	of	of	IN
cord-015021-pol2qm74	283	24	LPS	LPS	NNP
cord-015021-pol2qm74	283	25	(	(	-LRB-
cord-015021-pol2qm74	283	26	lipid	lipid	NN
cord-015021-pol2qm74	283	27	A	a	NN
cord-015021-pol2qm74	283	28	and	and	CC
cord-015021-pol2qm74	283	29	core	core	NN
cord-015021-pol2qm74	283	30	region	region	NN
cord-015021-pol2qm74	283	31	)	)	-RRB-
cord-015021-pol2qm74	283	32	.	.	.
cord-015021-pol2qm74	284	1	The	the	DT
cord-015021-pol2qm74	284	2	molecular	molecular	JJ
cord-015021-pol2qm74	284	3	basis	basis	NN
cord-015021-pol2qm74	284	4	of	of	IN
cord-015021-pol2qm74	284	5	this	this	DT
cord-015021-pol2qm74	284	6	approach	approach	NN
cord-015021-pol2qm74	284	7	and	and	CC
cord-015021-pol2qm74	284	8	the	the	DT
cord-015021-pol2qm74	284	9	controversy	controversy	NN
cord-015021-pol2qm74	284	10	in	in	IN
cord-015021-pol2qm74	284	11	this	this	DT
cord-015021-pol2qm74	284	12	field	field	NN
cord-015021-pol2qm74	284	13	will	will	MD
cord-015021-pol2qm74	284	14	be	be	VB
cord-015021-pol2qm74	284	15	discussed	discuss	VBN
cord-015021-pol2qm74	284	16	.	.	.
cord-015021-pol2qm74	285	1	Passive	passive	JJ
cord-015021-pol2qm74	285	2	immunotherapy	immunotherapy	NN
cord-015021-pol2qm74	285	3	has	have	VBZ
cord-015021-pol2qm74	285	4	been	be	VBN
cord-015021-pol2qm74	285	5	used	use	VBN
cord-015021-pol2qm74	285	6	since	since	IN
cord-015021-pol2qm74	285	7	1893	1893	CD
cord-015021-pol2qm74	285	8	,	,	,
cord-015021-pol2qm74	285	9	when	when	WRB
cord-015021-pol2qm74	285	10	von	von	NNP
cord-015021-pol2qm74	285	11	Behring	Behring	NNP
cord-015021-pol2qm74	285	12	described	describe	VBD
cord-015021-pol2qm74	285	13	the	the	DT
cord-015021-pol2qm74	285	14	administration	administration	NN
cord-015021-pol2qm74	285	15	of	of	IN
cord-015021-pol2qm74	285	16	immune	immune	JJ
cord-015021-pol2qm74	285	17	horse	horse	NN
cord-015021-pol2qm74	285	18	serum	serum	NN
cord-015021-pol2qm74	285	19	to	to	TO
cord-015021-pol2qm74	285	20	treat	treat	VB
cord-015021-pol2qm74	285	21	a	a	DT
cord-015021-pol2qm74	285	22	patient	patient	NN
cord-015021-pol2qm74	285	23	with	with	IN
cord-015021-pol2qm74	285	24	diphteria	diphteria	JJ
cord-015021-pol2qm74	285	25	infection	infection	NN
cord-015021-pol2qm74	285	26	.	.	.
cord-015021-pol2qm74	286	1	Even	even	RB
cord-015021-pol2qm74	286	2	if	if	IN
cord-015021-pol2qm74	286	3	this	this	DT
cord-015021-pol2qm74	286	4	therapy	therapy	NN
cord-015021-pol2qm74	286	5	was	be	VBD
cord-015021-pol2qm74	286	6	sometimes	sometimes	RB
cord-015021-pol2qm74	286	7	successful	successful	JJ
cord-015021-pol2qm74	286	8	in	in	IN
cord-015021-pol2qm74	286	9	bacterial	bacterial	JJ
cord-015021-pol2qm74	286	10	infections	infection	NNS
cord-015021-pol2qm74	286	11	,	,	,
cord-015021-pol2qm74	286	12	it	-PRON-	PRP
cord-015021-pol2qm74	286	13	has	have	VBZ
cord-015021-pol2qm74	286	14	been	be	VBN
cord-015021-pol2qm74	286	15	largely	largely	RB
cord-015021-pol2qm74	286	16	replaced	replace	VBN
cord-015021-pol2qm74	286	17	by	by	IN
cord-015021-pol2qm74	286	18	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	286	19	.	.	.
cord-015021-pol2qm74	287	1	However	however	RB
cord-015021-pol2qm74	287	2	,	,	,
cord-015021-pol2qm74	287	3	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	287	4	have	have	VBP
cord-015021-pol2qm74	287	5	their	-PRON-	PRP$
cord-015021-pol2qm74	287	6	limitations	limitation	NNS
cord-015021-pol2qm74	287	7	,	,	,
cord-015021-pol2qm74	287	8	especially	especially	RB
cord-015021-pol2qm74	287	9	in	in	IN
cord-015021-pol2qm74	287	10	critically	critically	RB
cord-015021-pol2qm74	287	11	-	-	HYPH
cord-015021-pol2qm74	287	12	ill	ill	JJ
cord-015021-pol2qm74	287	13	patients	patient	NNS
cord-015021-pol2qm74	287	14	.	.	.
cord-015021-pol2qm74	288	1	To	to	TO
cord-015021-pol2qm74	288	2	improve	improve	VB
cord-015021-pol2qm74	288	3	outcome	outcome	NN
cord-015021-pol2qm74	288	4	,	,	,
cord-015021-pol2qm74	288	5	adjunctive	adjunctive	JJ
cord-015021-pol2qm74	288	6	therapies	therapy	NNS
cord-015021-pol2qm74	288	7	such	such	JJ
cord-015021-pol2qm74	288	8	as	as	IN
cord-015021-pol2qm74	288	9	immunotherapy	immunotherapy	NN
cord-015021-pol2qm74	288	10	with	with	IN
cord-015021-pol2qm74	288	11	polyclonal	polyclonal	JJ
cord-015021-pol2qm74	288	12	and	and	CC
cord-015021-pol2qm74	288	13	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	288	14	antibodies	antibody	NNS
cord-015021-pol2qm74	288	15	particularly	particularly	RB
cord-015021-pol2qm74	288	16	against	against	IN
cord-015021-pol2qm74	288	17	endotoxin	endotoxin	NN
cord-015021-pol2qm74	288	18	are	be	VBP
cord-015021-pol2qm74	288	19	again	again	RB
cord-015021-pol2qm74	288	20	considered	consider	VBN
cord-015021-pol2qm74	288	21	.	.	.
cord-015021-pol2qm74	289	1	The	the	DT
cord-015021-pol2qm74	289	2	role	role	NN
cord-015021-pol2qm74	289	3	of	of	IN
cord-015021-pol2qm74	289	4	humoral	humoral	JJ
cord-015021-pol2qm74	289	5	immunity	immunity	NN
cord-015021-pol2qm74	289	6	in	in	IN
cord-015021-pol2qm74	289	7	host	host	NN
cord-015021-pol2qm74	289	8	defenses	defense	NNS
cord-015021-pol2qm74	289	9	against	against	IN
cord-015021-pol2qm74	289	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	289	11	infections	infection	NNS
cord-015021-pol2qm74	289	12	is	be	VBZ
cord-015021-pol2qm74	289	13	weU	weU	VBG
cord-015021-pol2qm74	289	14	known	know	VBN
cord-015021-pol2qm74	289	15	.	.	.
cord-015021-pol2qm74	290	1	For	for	IN
cord-015021-pol2qm74	290	2	instance	instance	NN
cord-015021-pol2qm74	290	3	,	,	,
cord-015021-pol2qm74	290	4	tile	tile	NN
cord-015021-pol2qm74	290	5	importance	importance	NN
cord-015021-pol2qm74	290	6	of	of	IN
cord-015021-pol2qm74	290	7	antibodies	antibody	NNS
cord-015021-pol2qm74	290	8	in	in	IN
cord-015021-pol2qm74	290	9	the	the	DT
cord-015021-pol2qm74	290	10	defense	defense	NN
cord-015021-pol2qm74	290	11	against	against	IN
cord-015021-pol2qm74	290	12	gramnegative	gramnegative	NNP
cord-015021-pol2qm74	290	13	infections	infection	NNS
cord-015021-pol2qm74	290	14	has	have	VBZ
cord-015021-pol2qm74	290	15	been	be	VBN
cord-015021-pol2qm74	290	16	established	establish	VBN
cord-015021-pol2qm74	290	17	clinically	clinically	RB
cord-015021-pol2qm74	290	18	by	by	IN
cord-015021-pol2qm74	290	19	studies	study	NNS
cord-015021-pol2qm74	290	20	relating	relate	VBG
cord-015021-pol2qm74	290	21	the	the	DT
cord-015021-pol2qm74	290	22	outcome	outcome	NN
cord-015021-pol2qm74	290	23	of	of	IN
cord-015021-pol2qm74	290	24	patients	patient	NNS
cord-015021-pol2qm74	290	25	with	with	IN
cord-015021-pol2qm74	290	26	gram	gram	JJ
cord-015021-pol2qm74	290	27	-	-	HYPH
cord-015021-pol2qm74	290	28	negative	negative	JJ
cord-015021-pol2qm74	290	29	bacteremia	bacteremia	NN
cord-015021-pol2qm74	290	30	to	to	IN
cord-015021-pol2qm74	290	31	tilers	tiler	NNS
cord-015021-pol2qm74	290	32	of	of	IN
cord-015021-pol2qm74	290	33	antibodies	antibody	NNS
cord-015021-pol2qm74	290	34	directed	direct	VBN
cord-015021-pol2qm74	290	35	at	at	IN
cord-015021-pol2qm74	290	36	the	the	DT
cord-015021-pol2qm74	290	37	offending	offend	VBG
cord-015021-pol2qm74	290	38	pathogens	pathogen	NNS
cord-015021-pol2qm74	290	39	at	at	IN
cord-015021-pol2qm74	290	40	the	the	DT
cord-015021-pol2qm74	290	41	onset	onset	NN
cord-015021-pol2qm74	290	42	ofbacteremia	ofbacteremia	NN
cord-015021-pol2qm74	290	43	(	(	-LRB-
cord-015021-pol2qm74	290	44	McCabe	McCabe	NNP
cord-015021-pol2qm74	290	45	1972	1972	CD
cord-015021-pol2qm74	290	46	;	;	:
cord-015021-pol2qm74	290	47	Pollack	Pollack	NNP
cord-015021-pol2qm74	290	48	1979	1979	CD
cord-015021-pol2qm74	290	49	)	)	-RRB-
cord-015021-pol2qm74	290	50	.	.	.
cord-015021-pol2qm74	291	1	Ever	ever	RB
cord-015021-pol2qm74	291	2	since	since	IN
cord-015021-pol2qm74	291	3	we	-PRON-	PRP
cord-015021-pol2qm74	291	4	know	know	VBP
cord-015021-pol2qm74	291	5	the	the	DT
cord-015021-pol2qm74	291	6	role	role	NN
cord-015021-pol2qm74	291	7	of	of	IN
cord-015021-pol2qm74	291	8	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	291	9	in	in	IN
cord-015021-pol2qm74	291	10	the	the	DT
cord-015021-pol2qm74	291	11	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	291	12	of	of	IN
cord-015021-pol2qm74	291	13	sepsis	sepsis	NN
cord-015021-pol2qm74	291	14	,	,	,
cord-015021-pol2qm74	291	15	antibodies	antibody	NNS
cord-015021-pol2qm74	291	16	against	against	IN
cord-015021-pol2qm74	291	17	the	the	DT
cord-015021-pol2qm74	291	18	S	S	NNP
cord-015021-pol2qm74	291	19	-	-	HYPH
cord-015021-pol2qm74	291	20	and	and	CC
cord-015021-pol2qm74	291	21	R	R	NNP
cord-015021-pol2qm74	291	22	-	-	HYPH
cord-015021-pol2qm74	291	23	LPS	lp	NNS
cord-015021-pol2qm74	291	24	have	have	VBP
cord-015021-pol2qm74	291	25	also	also	RB
cord-015021-pol2qm74	291	26	been	be	VBN
cord-015021-pol2qm74	291	27	detected	detect	VBN
cord-015021-pol2qm74	291	28	in	in	IN
cord-015021-pol2qm74	291	29	sepsis	sepsis	NN
cord-015021-pol2qm74	291	30	patients	patient	NNS
cord-015021-pol2qm74	291	31	.	.	.
cord-015021-pol2qm74	292	1	The	the	DT
cord-015021-pol2qm74	292	2	aim	aim	NN
cord-015021-pol2qm74	292	3	of	of	IN
cord-015021-pol2qm74	292	4	the	the	DT
cord-015021-pol2qm74	292	5	administration	administration	NN
cord-015021-pol2qm74	292	6	of	of	IN
cord-015021-pol2qm74	292	7	IV	IV	NNP
cord-015021-pol2qm74	292	8	/	/	SYM
cord-015021-pol2qm74	292	9	G	g	NN
cord-015021-pol2qm74	292	10	to	to	IN
cord-015021-pol2qm74	292	11	the	the	DT
cord-015021-pol2qm74	292	12	sepsis	sepsis	NN
cord-015021-pol2qm74	292	13	patient	patient	NN
cord-015021-pol2qm74	292	14	is	be	VBZ
cord-015021-pol2qm74	292	15	as	as	IN
cord-015021-pol2qm74	292	16	follows	follow	VBZ
cord-015021-pol2qm74	292	17	:	:	:
cord-015021-pol2qm74	293	1	1	1	LS
cord-015021-pol2qm74	293	2	)	)	-RRB-
cord-015021-pol2qm74	293	3	Enhancing	enhancing	NN
cord-015021-pol2qm74	293	4	of	of	IN
cord-015021-pol2qm74	293	5	opsonization	opsonization	NN
cord-015021-pol2qm74	293	6	and	and	CC
cord-015021-pol2qm74	293	7	phagocytosis(antibactericidaI	phagocytosis(antibactericidaI	NNP
cord-015021-pol2qm74	293	8	activity	activity	NN
cord-015021-pol2qm74	293	9	)	)	-RRB-
cord-015021-pol2qm74	293	10	2	2	CD
cord-015021-pol2qm74	293	11	)	)	-RRB-
cord-015021-pol2qm74	294	1	Synergistic	synergistic	JJ
cord-015021-pol2qm74	294	2	effects	effect	NNS
cord-015021-pol2qm74	294	3	with	with	IN
cord-015021-pol2qm74	294	4	[	[	-LRB-
cord-015021-pol2qm74	294	5	3	3	CD
cord-015021-pol2qm74	294	6	-	-	SYM
cord-015021-pol2qm74	294	7	1actam	1actam	CD
cord-015021-pol2qm74	294	8	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	294	9	3	3	CD
cord-015021-pol2qm74	294	10	)	)	-RRB-
cord-015021-pol2qm74	295	1	Neutralization	neutralization	NN
cord-015021-pol2qm74	295	2	of	of	IN
cord-015021-pol2qm74	295	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	295	4	,	,	,
cord-015021-pol2qm74	295	5	the	the	DT
cord-015021-pol2qm74	295	6	main	main	JJ
cord-015021-pol2qm74	295	7	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	295	8	mediator	mediator	NN
cord-015021-pol2qm74	295	9	of	of	IN
cord-015021-pol2qm74	295	10	gram	gram	JJ
cord-015021-pol2qm74	295	11	-	-	HYPH
cord-015021-pol2qm74	295	12	negative	negative	JJ
cord-015021-pol2qm74	295	13	sepsis	sepsis	NN
cord-015021-pol2qm74	295	14	4	4	CD
cord-015021-pol2qm74	295	15	)	)	-RRB-
cord-015021-pol2qm74	296	1	Modulation	modulation	NN
cord-015021-pol2qm74	296	2	and/or	and/or	CC
cord-015021-pol2qm74	296	3	inhibition	inhibition	NN
cord-015021-pol2qm74	296	4	of	of	IN
cord-015021-pol2qm74	296	5	cytokine	cytokine	NN
cord-015021-pol2qm74	296	6	release	release	NN
cord-015021-pol2qm74	297	1	The	the	DT
cord-015021-pol2qm74	297	2	enhancement	enhancement	NN
cord-015021-pol2qm74	297	3	of	of	IN
cord-015021-pol2qm74	297	4	opsonic	opsonic	JJ
cord-015021-pol2qm74	297	5	-	-	HYPH
cord-015021-pol2qm74	297	6	and	and	CC
cord-015021-pol2qm74	297	7	phagocytic	phagocytic	NN
cord-015021-pol2qm74	297	8	-	-	HYPH
cord-015021-pol2qm74	297	9	activity	activity	NN
cord-015021-pol2qm74	297	10	especially	especially	RB
cord-015021-pol2qm74	297	11	with	with	IN
cord-015021-pol2qm74	297	12	IgG	igg	NN
cord-015021-pol2qm74	297	13	via	via	IN
cord-015021-pol2qm74	297	14	Fc	Fc	NNP
cord-015021-pol2qm74	297	15	and	and	CC
cord-015021-pol2qm74	297	16	C3	C3	NNP
cord-015021-pol2qm74	297	17	receptors	receptor	NNS
cord-015021-pol2qm74	297	18	has	have	VBZ
cord-015021-pol2qm74	297	19	been	be	VBN
cord-015021-pol2qm74	297	20	well	well	RB
cord-015021-pol2qm74	297	21	documented	document	VBN
cord-015021-pol2qm74	297	22	.	.	.
cord-015021-pol2qm74	298	1	Monoclonal	monoclonal	JJ
cord-015021-pol2qm74	298	2	antiendotoxin	antiendotoxin	NN
cord-015021-pol2qm74	298	3	antibodies	antibody	NNS
cord-015021-pol2qm74	298	4	,	,	,
cord-015021-pol2qm74	298	5	proven	prove	VBN
cord-015021-pol2qm74	298	6	in	in	IN
cord-015021-pol2qm74	298	7	clinical	clinical	JJ
cord-015021-pol2qm74	298	8	studies	study	NNS
cord-015021-pol2qm74	298	9	,	,	,
cord-015021-pol2qm74	298	10	do	do	VBP
cord-015021-pol2qm74	298	11	not	not	RB
cord-015021-pol2qm74	298	12	appear	appear	VB
cord-015021-pol2qm74	298	13	to	to	TO
cord-015021-pol2qm74	298	14	neutralize	neutralize	VB
cord-015021-pol2qm74	298	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	298	16	in	in	IN
cord-015021-pol2qm74	298	17	vitro	vitro	FW
cord-015021-pol2qm74	298	18	and	and	CC
cord-015021-pol2qm74	298	19	are	be	VBP
cord-015021-pol2qm74	298	20	not	not	RB
cord-015021-pol2qm74	298	21	reproducibly	reproducibly	RB
cord-015021-pol2qm74	298	22	protective	protective	JJ
cord-015021-pol2qm74	298	23	in	in	IN
cord-015021-pol2qm74	298	24	animal	animal	NN
cord-015021-pol2qm74	298	25	models	model	NNS
cord-015021-pol2qm74	298	26	of	of	IN
cord-015021-pol2qm74	298	27	sepsis	sepsis	NN
cord-015021-pol2qm74	298	28	.	.	.
cord-015021-pol2qm74	299	1	Also	also	RB
cord-015021-pol2qm74	299	2	they	-PRON-	PRP
cord-015021-pol2qm74	299	3	can	can	MD
cord-015021-pol2qm74	299	4	not	not	RB
cord-015021-pol2qm74	299	5	suppress	suppress	VB
cord-015021-pol2qm74	299	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	299	7	-	-	HYPH
cord-015021-pol2qm74	299	8	induced	induce	VBN
cord-015021-pol2qm74	299	9	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	299	10	,	,	,
cord-015021-pol2qm74	299	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	299	12	release	release	NN
cord-015021-pol2qm74	299	13	in	in	IN
cord-015021-pol2qm74	299	14	mice	mouse	NNS
cord-015021-pol2qm74	299	15	(	(	-LRB-
cord-015021-pol2qm74	299	16	Baumgartner	Baumgartner	NNP
cord-015021-pol2qm74	299	17	1990	1990	CD
cord-015021-pol2qm74	299	18	,	,	,
cord-015021-pol2qm74	299	19	Corriveau	Corriveau	NNP
cord-015021-pol2qm74	299	20	and	and	CC
cord-015021-pol2qm74	299	21	Danner	Danner	NNP
cord-015021-pol2qm74	299	22	1993	1993	CD
cord-015021-pol2qm74	299	23	)	)	-RRB-
cord-015021-pol2qm74	299	24	.	.	.
cord-015021-pol2qm74	300	1	In	in	IN
cord-015021-pol2qm74	300	2	conlrast	conlrast	NN
cord-015021-pol2qm74	300	3	,	,	,
cord-015021-pol2qm74	300	4	recent	recent	JJ
cord-015021-pol2qm74	300	5	studies	study	NNS
cord-015021-pol2qm74	300	6	of	of	IN
cord-015021-pol2qm74	300	7	a	a	DT
cord-015021-pol2qm74	300	8	polyclonal	polyclonal	JJ
cord-015021-pol2qm74	300	9	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	300	10	preparation	preparation	NN
cord-015021-pol2qm74	300	11	,	,	,
cord-015021-pol2qm74	300	12	containing	contain	VBG
cord-015021-pol2qm74	300	13	high	high	JJ
cord-015021-pol2qm74	300	14	levels	level	NNS
cord-015021-pol2qm74	300	15	of	of	IN
cord-015021-pol2qm74	300	16	antibodies	antibody	NNS
cord-015021-pol2qm74	300	17	against	against	IN
cord-015021-pol2qm74	300	18	gram	gram	NN
cord-015021-pol2qm74	300	19	-	-	HYPH
cord-015021-pol2qm74	300	20	negative	negative	JJ
cord-015021-pol2qm74	300	21	bacteria	bacteria	NNS
cord-015021-pol2qm74	300	22	and	and	CC
cord-015021-pol2qm74	300	23	their	-PRON-	PRP$
cord-015021-pol2qm74	300	24	O	o	NN
cord-015021-pol2qm74	300	25	-	-	HYPH
cord-015021-pol2qm74	300	26	antigen	antigen	NN
cord-015021-pol2qm74	300	27	of	of	IN
cord-015021-pol2qm74	300	28	LPS	LPS	NNP
cord-015021-pol2qm74	300	29	in	in	IN
cord-015021-pol2qm74	300	30	IgG	IgG	NNP
cord-015021-pol2qm74	300	31	,	,	,
cord-015021-pol2qm74	300	32	IgM	IgM	NNP
cord-015021-pol2qm74	300	33	and	and	CC
cord-015021-pol2qm74	300	34	IgA	IgA	NNP
cord-015021-pol2qm74	300	35	classes	class	NNS
cord-015021-pol2qm74	301	1	(	(	-LRB-
cord-015021-pol2qm74	301	2	Pentaglobin	Pentaglobin	NNP
cord-015021-pol2qm74	301	3	®	®	POS
cord-015021-pol2qm74	301	4	)	)	-RRB-
cord-015021-pol2qm74	301	5	provide	provide	VBP
cord-015021-pol2qm74	301	6	evidence	evidence	NN
cord-015021-pol2qm74	301	7	to	to	TO
cord-015021-pol2qm74	301	8	neutralize	neutralize	VB
cord-015021-pol2qm74	301	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	301	10	.	.	.
cord-015021-pol2qm74	302	1	This	this	DT
cord-015021-pol2qm74	302	2	effect	effect	NN
cord-015021-pol2qm74	302	3	is	be	VBZ
cord-015021-pol2qm74	302	4	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	302	5	in	in	IN
cord-015021-pol2qm74	302	6	vitro	vitro	FW
cord-015021-pol2qm74	302	7	(	(	-LRB-
cord-015021-pol2qm74	302	8	Berger	Berger	NNP
cord-015021-pol2qm74	302	9	1990	1990	CD
cord-015021-pol2qm74	302	10	(	(	-LRB-
cord-015021-pol2qm74	302	11	Berger	Berger	NNP
cord-015021-pol2qm74	302	12	,	,	,
cord-015021-pol2qm74	302	13	1993	1993	CD
cord-015021-pol2qm74	302	14	,	,	,
cord-015021-pol2qm74	302	15	in	in	IN
cord-015021-pol2qm74	302	16	animal	animal	NN
cord-015021-pol2qm74	302	17	models	model	NNS
cord-015021-pol2qm74	302	18	(	(	-LRB-
cord-015021-pol2qm74	302	19	Stephan	Stephan	NNP
cord-015021-pol2qm74	302	20	1985	1985	CD
cord-015021-pol2qm74	302	21	,	,	,
cord-015021-pol2qm74	302	22	Berger	Berger	NNP
cord-015021-pol2qm74	302	23	1993	1993	CD
cord-015021-pol2qm74	302	24	and	and	CC
cord-015021-pol2qm74	302	25	also	also	RB
cord-015021-pol2qm74	302	26	in	in	IN
cord-015021-pol2qm74	302	27	prospective	prospective	JJ
cord-015021-pol2qm74	302	28	,	,	,
cord-015021-pol2qm74	302	29	randomized	randomized	JJ
cord-015021-pol2qm74	302	30	,	,	,
cord-015021-pol2qm74	302	31	controlled	control	VBN
cord-015021-pol2qm74	302	32	clinical	clinical	JJ
cord-015021-pol2qm74	302	33	trials	trial	NNS
cord-015021-pol2qm74	302	34	(	(	-LRB-
cord-015021-pol2qm74	302	35	Schedel	Schedel	NNP
cord-015021-pol2qm74	302	36	1991	1991	CD
cord-015021-pol2qm74	302	37	,	,	,
cord-015021-pol2qm74	302	38	Poynton	Poynton	NNP
cord-015021-pol2qm74	302	39	1992	1992	CD
cord-015021-pol2qm74	302	40	,	,	,
cord-015021-pol2qm74	302	41	Behre	Behre	NNP
cord-015021-pol2qm74	302	42	1992	1992	CD
cord-015021-pol2qm74	302	43	.	.	.
cord-015021-pol2qm74	303	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	303	2	mortali	mortali	NNP
cord-015021-pol2qm74	303	3	b	b	NNP
cord-015021-pol2qm74	303	4	'	'	''
cord-015021-pol2qm74	303	5	was	be	VBD
cord-015021-pol2qm74	303	6	reduced	reduce	VBN
cord-015021-pol2qm74	303	7	statistically	statistically	RB
cord-015021-pol2qm74	303	8	in	in	IN
cord-015021-pol2qm74	303	9	patients	patient	NNS
cord-015021-pol2qm74	303	10	with	with	IN
cord-015021-pol2qm74	303	11	septic	septic	JJ
cord-015021-pol2qm74	303	12	shock	shock	NN
cord-015021-pol2qm74	303	13	and	and	CC
cord-015021-pol2qm74	303	14	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	303	15	by	by	IN
cord-015021-pol2qm74	303	16	using	use	VBG
cord-015021-pol2qm74	303	17	this	this	DT
cord-015021-pol2qm74	303	18	preparation	preparation	NN
cord-015021-pol2qm74	303	19	,	,	,
cord-015021-pol2qm74	303	20	as	as	IN
cord-015021-pol2qm74	303	21	has	have	VBZ
cord-015021-pol2qm74	303	22	been	be	VBN
cord-015021-pol2qm74	303	23	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	303	24	by	by	IN
cord-015021-pol2qm74	303	25	Sehedel	Sehedel	NNP
cord-015021-pol2qm74	303	26	.	.	.
cord-015021-pol2qm74	304	1	Anti	anti	JJ
cord-015021-pol2qm74	304	2	-	-	JJ
cord-015021-pol2qm74	304	3	core	core	JJ
cord-015021-pol2qm74	304	4	LPS	LPS	NNP
cord-015021-pol2qm74	304	5	monoolonal	monoolonal	JJ
cord-015021-pol2qm74	304	6	antibodies	antibody	NNS
cord-015021-pol2qm74	304	7	:	:	:
cord-015021-pol2qm74	304	8	Binding	bind	VBG
cord-015021-pol2qm74	304	9	specificity	specificity	NN
cord-015021-pol2qm74	304	10	and	and	CC
cord-015021-pol2qm74	304	11	biological	biological	JJ
cord-015021-pol2qm74	304	12	properties	property	NNS
cord-015021-pol2qm74	304	13	F.E.	F.E.	NNP
cord-015021-pol2qm74	304	14	Di	Di	NNP
cord-015021-pol2qm74	304	15	Padova	Padova	NNP
cord-015021-pol2qm74	304	16	,	,	,
cord-015021-pol2qm74	304	17	R.	R.	NNP
cord-015021-pol2qm74	304	18	Barclay	Barclay	NNP
cord-015021-pol2qm74	304	19	,	,	,
cord-015021-pol2qm74	304	20	E.Th	E.Th	NNP
cord-015021-pol2qm74	304	21	.	.	.
cord-015021-pol2qm74	305	1	Rietschel	Rietschel	NNP
cord-015021-pol2qm74	305	2	.	.	.
cord-015021-pol2qm74	306	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	306	2	LPS	lp	NNS
cord-015021-pol2qm74	306	3	and	and	CC
cord-015021-pol2qm74	306	4	cytokines	cytokine	NNS
cord-015021-pol2qm74	306	5	are	be	VBP
cord-015021-pol2qm74	306	6	responsible	responsible	JJ
cord-015021-pol2qm74	306	7	for	for	IN
cord-015021-pol2qm74	306	8	the	the	DT
cord-015021-pol2qm74	306	9	pathological	pathological	JJ
cord-015021-pol2qm74	306	10	processes	process	NNS
cord-015021-pol2qm74	306	11	of	of	IN
cord-015021-pol2qm74	306	12	Gram	gram	NN
cord-015021-pol2qm74	306	13	-	-	HYPH
cord-015021-pol2qm74	306	14	sepsis	sepsis	NN
cord-015021-pol2qm74	306	15	and	and	CC
cord-015021-pol2qm74	306	16	are	be	VBP
cord-015021-pol2qm74	306	17	suitable	suitable	JJ
cord-015021-pol2qm74	306	18	targets	target	NNS
cord-015021-pol2qm74	306	19	for	for	IN
cord-015021-pol2qm74	306	20	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	306	21	interventions	intervention	NNS
cord-015021-pol2qm74	306	22	.	.	.
cord-015021-pol2qm74	307	1	Chemical	chemical	JJ
cord-015021-pol2qm74	307	2	characterization	characterization	NN
cord-015021-pol2qm74	307	3	and	and	CC
cord-015021-pol2qm74	307	4	structural	structural	JJ
cord-015021-pol2qm74	307	5	analysis	analysis	NN
cord-015021-pol2qm74	307	6	of	of	IN
cord-015021-pol2qm74	307	7	different	different	JJ
cord-015021-pol2qm74	307	8	LPS	lp	NNS
cord-015021-pol2qm74	307	9	have	have	VBP
cord-015021-pol2qm74	307	10	revealed	reveal	VBN
cord-015021-pol2qm74	307	11	common	common	JJ
cord-015021-pol2qm74	307	12	features	feature	NNS
cord-015021-pol2qm74	307	13	.	.	.
cord-015021-pol2qm74	308	1	The	the	DT
cord-015021-pol2qm74	308	2	inner	inner	JJ
cord-015021-pol2qm74	308	3	core	core	NN
cord-015021-pol2qm74	308	4	region	region	NN
cord-015021-pol2qm74	308	5	of	of	IN
cord-015021-pol2qm74	308	6	LPS	LPS	NNP
cord-015021-pol2qm74	308	7	shows	show	VBZ
cord-015021-pol2qm74	308	8	a	a	DT
cord-015021-pol2qm74	308	9	high	high	JJ
cord-015021-pol2qm74	308	10	degree	degree	NN
cord-015021-pol2qm74	308	11	of	of	IN
cord-015021-pol2qm74	308	12	similarity	similarity	NN
cord-015021-pol2qm74	308	13	among	among	IN
cord-015021-pol2qm74	308	14	E.	E.	NNP
cord-015021-pol2qm74	308	15	coli	coli	NNS
cord-015021-pol2qm74	308	16	,	,	,
cord-015021-pol2qm74	308	17	Salmonella	Salmonella	NNP
cord-015021-pol2qm74	308	18	and	and	CC
cord-015021-pol2qm74	308	19	Shigella	Shigella	NNP
cord-015021-pol2qm74	308	20	.	.	.
cord-015021-pol2qm74	309	1	Among	among	IN
cord-015021-pol2qm74	309	2	a	a	DT
cord-015021-pol2qm74	309	3	large	large	JJ
cord-015021-pol2qm74	309	4	number	number	NN
cord-015021-pol2qm74	309	5	of	of	IN
cord-015021-pol2qm74	309	6	broadly	broadly	RB
cord-015021-pol2qm74	309	7	cross	cross	JJ
cord-015021-pol2qm74	309	8	-	-	JJ
cord-015021-pol2qm74	309	9	reactive	reactive	JJ
cord-015021-pol2qm74	309	10	murine	murine	JJ
cord-015021-pol2qm74	309	11	anti	anti	JJ
cord-015021-pol2qm74	309	12	-	-	JJ
cord-015021-pol2qm74	309	13	core	core	JJ
cord-015021-pol2qm74	309	14	LPS	lp	NNS
cord-015021-pol2qm74	309	15	MAb	MAb	NNPS
cord-015021-pol2qm74	309	16	one	one	CD
cord-015021-pol2qm74	309	17	of	of	IN
cord-015021-pol2qm74	309	18	these	these	DT
cord-015021-pol2qm74	309	19	 	 	_SP
cord-015021-pol2qm74	309	20	IgG2ak	IgG2ak	NNP
cord-015021-pol2qm74	309	21	)	)	-RRB-
cord-015021-pol2qm74	309	22	has	have	VBZ
cord-015021-pol2qm74	309	23	been	be	VBN
cord-015021-pol2qm74	309	24	selected	select	VBN
cord-015021-pol2qm74	309	25	and	and	CC
cord-015021-pol2qm74	309	26	chimerized	chimerize	VBN
cord-015021-pol2qm74	309	27	into	into	IN
cord-015021-pol2qm74	309	28	a	a	DT
cord-015021-pol2qm74	309	29	human	human	JJ
cord-015021-pol2qm74	309	30	IgGlk	IgGlk	NNP
cord-015021-pol2qm74	309	31	(	(	-LRB-
cord-015021-pol2qm74	309	32	SDZ	SDZ	NNP
cord-015021-pol2qm74	309	33	219	219	CD
cord-015021-pol2qm74	309	34	-	-	SYM
cord-015021-pol2qm74	309	35	800	800	CD
cord-015021-pol2qm74	309	36	)	)	-RRB-
cord-015021-pol2qm74	309	37	.	.	.
cord-015021-pol2qm74	310	1	In	in	IN
cord-015021-pol2qm74	310	2	ELISA	ELISA	NNP
cord-015021-pol2qm74	310	3	and	and	CC
cord-015021-pol2qm74	310	4	in	in	IN
cord-015021-pol2qm74	310	5	immunoblots	immunoblot	NNS
cord-015021-pol2qm74	310	6	on	on	IN
cord-015021-pol2qm74	310	7	purified	purify	VBN
cord-015021-pol2qm74	310	8	LPS	LPS	NNP
cord-015021-pol2qm74	310	9	both	both	CC
cord-015021-pol2qm74	310	10	SDZ	SDZ	NNP
cord-015021-pol2qm74	310	11	219	219	CD
cord-015021-pol2qm74	310	12	-	-	SYM
cord-015021-pol2qm74	310	13	800	800	CD
cord-015021-pol2qm74	310	14	and	and	CC
cord-015021-pol2qm74	310	15	WNI	WNI	NNP
cord-015021-pol2qm74	310	16	222	222	CD
cord-015021-pol2qm74	310	17	-	-	SYM
cord-015021-pol2qm74	310	18	5	5	CD
cord-015021-pol2qm74	310	19	show	show	VBP
cord-015021-pol2qm74	310	20	a	a	DT
cord-015021-pol2qm74	310	21	strong	strong	JJ
cord-015021-pol2qm74	310	22	reactivity	reactivity	NN
cord-015021-pol2qm74	310	23	with	with	IN
cord-015021-pol2qm74	310	24	all	all	DT
cord-015021-pol2qm74	310	25	smooth	smooth	JJ
cord-015021-pol2qm74	310	26	LPS	lp	NNS
cord-015021-pol2qm74	310	27	from	from	IN
cord-015021-pol2qm74	310	28	E.	E.	NNP
cord-015021-pol2qm74	310	29	coli	coli	NNS
cord-015021-pol2qm74	310	30	and	and	CC
cord-015021-pol2qm74	310	31	Salmonella	Salmonella	NNP
cord-015021-pol2qm74	310	32	.	.	.
cord-015021-pol2qm74	311	1	Reactivity	reactivity	NN
cord-015021-pol2qm74	311	2	with	with	IN
cord-015021-pol2qm74	311	3	all	all	PDT
cord-015021-pol2qm74	311	4	the	the	DT
cord-015021-pol2qm74	311	5	known	know	VBN
cord-015021-pol2qm74	311	6	complete	complete	JJ
cord-015021-pol2qm74	311	7	core	core	NN
cord-015021-pol2qm74	311	8	structures	structure	NNS
cord-015021-pol2qm74	311	9	from	from	IN
cord-015021-pol2qm74	311	10	E.	E.	NNP
cord-015021-pol2qm74	311	11	coli	coli	NNS
cord-015021-pol2qm74	311	12	and	and	CC
cord-015021-pol2qm74	311	13	Salmonella	Salmonella	NNP
cord-015021-pol2qm74	311	14	(	(	-LRB-
cord-015021-pol2qm74	311	15	Ra	Ra	NNP
cord-015021-pol2qm74	311	16	)	)	-RRB-
cord-015021-pol2qm74	311	17	is	be	VBZ
cord-015021-pol2qm74	311	18	evident	evident	JJ
cord-015021-pol2qm74	311	19	.	.	.
cord-015021-pol2qm74	312	1	Reactivity	reactivity	NN
cord-015021-pol2qm74	312	2	with	with	IN
cord-015021-pol2qm74	312	3	Re	Re	VBG
cord-015021-pol2qm74	312	4	structures	structure	NNS
cord-015021-pol2qm74	312	5	or	or	CC
cord-015021-pol2qm74	312	6	free	free	JJ
cord-015021-pol2qm74	312	7	lipid	lipid	NN
cord-015021-pol2qm74	312	8	A	a	NN
cord-015021-pol2qm74	312	9	is	be	VBZ
cord-015021-pol2qm74	312	10	not	not	RB
cord-015021-pol2qm74	312	11	observed	observe	VBN
cord-015021-pol2qm74	312	12	.	.	.
cord-015021-pol2qm74	313	1	This	this	DT
cord-015021-pol2qm74	313	2	MAb	MAb	VBZ
cord-015021-pol2qm74	313	3	cressreacts	cressreact	VBZ
cord-015021-pol2qm74	313	4	with	with	IN
cord-015021-pol2qm74	313	5	all	all	DT
cord-015021-pol2qm74	313	6	clinical	clinical	JJ
cord-015021-pol2qm74	313	7	E.	E.	NNP
cord-015021-pol2qm74	313	8	coli	coli	NNS
cord-015021-pol2qm74	313	9	isolates	isolate	NNS
cord-015021-pol2qm74	313	10	from	from	IN
cord-015021-pol2qm74	313	11	blood	blood	NN
cord-015021-pol2qm74	313	12	,	,	,
cord-015021-pol2qm74	313	13	urine	urine	NN
cord-015021-pol2qm74	313	14	and	and	CC
cord-015021-pol2qm74	313	15	feces	fece	NNS
cord-015021-pol2qm74	313	16	and	and	CC
cord-015021-pol2qm74	313	17	with	with	IN
cord-015021-pol2qm74	313	18	other	other	JJ
cord-015021-pol2qm74	313	19	enterobacteriaceae	enterobacteriaceae	NNS
cord-015021-pol2qm74	313	20	.	.	.
cord-015021-pol2qm74	314	1	SDZ	SDZ	NNP
cord-015021-pol2qm74	314	2	219	219	CD
cord-015021-pol2qm74	314	3	-	-	SYM
cord-015021-pol2qm74	314	4	800	800	CD
cord-015021-pol2qm74	314	5	and	and	CC
cord-015021-pol2qm74	314	6	WNI	WNI	NNP
cord-015021-pol2qm74	314	7	222	222	CD
cord-015021-pol2qm74	314	8	-	-	SYM
cord-015021-pol2qm74	314	9	5	5	CD
cord-015021-pol2qm74	314	10	have	have	VBP
cord-015021-pol2qm74	314	11	biological	biological	JJ
cord-015021-pol2qm74	314	12	activity	activity	NN
cord-015021-pol2qm74	314	13	as	as	IN
cord-015021-pol2qm74	314	14	they	-PRON-	PRP
cord-015021-pol2qm74	314	15	inhibit	inhibit	VBP
cord-015021-pol2qm74	314	16	the	the	DT
cord-015021-pol2qm74	314	17	LAL	LAL	NNP
cord-015021-pol2qm74	314	18	assay	assay	NN
cord-015021-pol2qm74	314	19	and	and	CC
cord-015021-pol2qm74	314	20	the	the	DT
cord-015021-pol2qm74	314	21	secretion	secretion	NN
cord-015021-pol2qm74	314	22	of	of	IN
cord-015021-pol2qm74	314	23	monokines	monokines	NNP
cord-015021-pol2qm74	314	24	(	(	-LRB-
cord-015021-pol2qm74	314	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	314	26	and	and	CC
cord-015021-pol2qm74	314	27	TNF	TNF	NNP
cord-015021-pol2qm74	314	28	)	)	-RRB-
cord-015021-pol2qm74	314	29	by	by	IN
cord-015021-pol2qm74	314	30	mouse	mouse	NN
cord-015021-pol2qm74	314	31	and	and	CC
cord-015021-pol2qm74	314	32	human	human	JJ
cord-015021-pol2qm74	314	33	macrophages	macrophage	NNS
cord-015021-pol2qm74	314	34	.	.	.
cord-015021-pol2qm74	315	1	Moreover	moreover	RB
cord-015021-pol2qm74	315	2	,	,	,
cord-015021-pol2qm74	315	3	SDZ	SDZ	NNP
cord-015021-pol2qm74	315	4	219	219	CD
cord-015021-pol2qm74	315	5	-	-	SYM
cord-015021-pol2qm74	315	6	800	800	CD
cord-015021-pol2qm74	315	7	and	and	CC
cord-015021-pol2qm74	315	8	WNI	WNI	NNP
cord-015021-pol2qm74	315	9	222	222	CD
cord-015021-pol2qm74	315	10	-	-	SYM
cord-015021-pol2qm74	315	11	5	5	CD
cord-015021-pol2qm74	315	12	inhibit	inhibit	VBP
cord-015021-pol2qm74	315	13	the	the	DT
cord-015021-pol2qm74	315	14	release	release	NN
cord-015021-pol2qm74	315	15	of	of	IN
cord-015021-pol2qm74	315	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	315	17	and	and	CC
cord-015021-pol2qm74	315	18	TNF	TNF	NNP
cord-015021-pol2qm74	315	19	in	in	IN
cord-015021-pol2qm74	315	20	vivo	vivo	NNP
cord-015021-pol2qm74	315	21	.	.	.
cord-015021-pol2qm74	316	1	In	in	IN
cord-015021-pol2qm74	316	2	vivo	vivo	NNP
cord-015021-pol2qm74	316	3	SDZ	SDZ	NNP
cord-015021-pol2qm74	316	4	219	219	CD
cord-015021-pol2qm74	316	5	-	-	SYM
cord-015021-pol2qm74	316	6	800	800	CD
cord-015021-pol2qm74	316	7	as	as	RB
cord-015021-pol2qm74	316	8	well	well	RB
cord-015021-pol2qm74	316	9	as	as	IN
cord-015021-pol2qm74	316	10	WNI	WNI	NNP
cord-015021-pol2qm74	316	11	222	222	CD
cord-015021-pol2qm74	316	12	-	-	SYM
cord-015021-pol2qm74	316	13	5	5	CD
cord-015021-pol2qm74	316	14	neutralize	neutralize	VB
cord-015021-pol2qm74	316	15	the	the	DT
cord-015021-pol2qm74	316	16	pyrogenic	pyrogenic	JJ
cord-015021-pol2qm74	316	17	activity	activity	NN
cord-015021-pol2qm74	316	18	of	of	IN
cord-015021-pol2qm74	316	19	E.	E.	NNP
cord-015021-pol2qm74	316	20	coli	coli	VBZ
cord-015021-pol2qm74	316	21	LPS	lp	NNS
cord-015021-pol2qm74	316	22	and	and	CC
cord-015021-pol2qm74	316	23	protect	protect	VB
cord-015021-pol2qm74	316	24	mice	mouse	NNS
cord-015021-pol2qm74	316	25	from	from	IN
cord-015021-pol2qm74	316	26	lethality	lethality	NN
cord-015021-pol2qm74	316	27	in	in	IN
cord-015021-pol2qm74	316	28	D	D	NNP
cord-015021-pol2qm74	316	29	-	-	HYPH
cord-015021-pol2qm74	316	30	GaiN	gain	NN
cord-015021-pol2qm74	316	31	-	-	HYPH
cord-015021-pol2qm74	316	32	sensitized	sensitize	VBN
cord-015021-pol2qm74	316	33	mice	mouse	NNS
cord-015021-pol2qm74	316	34	.	.	.
cord-015021-pol2qm74	317	1	The	the	DT
cord-015021-pol2qm74	317	2	possibility	possibility	NN
cord-015021-pol2qm74	317	3	to	to	TO
cord-015021-pol2qm74	317	4	use	use	VB
cord-015021-pol2qm74	317	5	WNI	WNI	NNP
cord-015021-pol2qm74	317	6	222	222	CD
cord-015021-pol2qm74	317	7	-	-	SYM
cord-015021-pol2qm74	317	8	5	5	CD
cord-015021-pol2qm74	317	9	as	as	IN
cord-015021-pol2qm74	317	10	a	a	DT
cord-015021-pol2qm74	317	11	capture	capture	NN
cord-015021-pol2qm74	317	12	antibodies	antibody	NNS
cord-015021-pol2qm74	317	13	in	in	IN
cord-015021-pol2qm74	317	14	the	the	DT
cord-015021-pol2qm74	317	15	immunolimulus	immunolimulus	JJ
cord-015021-pol2qm74	317	16	assay	assay	NN
cord-015021-pol2qm74	317	17	opens	open	VBZ
cord-015021-pol2qm74	317	18	the	the	DT
cord-015021-pol2qm74	317	19	possibility	possibility	NN
cord-015021-pol2qm74	317	20	to	to	TO
cord-015021-pol2qm74	317	21	differentiate	differentiate	VB
cord-015021-pol2qm74	317	22	the	the	DT
cord-015021-pol2qm74	317	23	origin	origin	NN
cord-015021-pol2qm74	317	24	of	of	IN
cord-015021-pol2qm74	317	25	the	the	DT
cord-015021-pol2qm74	317	26	LPS	LPS	NNP
cord-015021-pol2qm74	317	27	in	in	IN
cord-015021-pol2qm74	317	28	patients	patient	NNS
cord-015021-pol2qm74	317	29	with	with	IN
cord-015021-pol2qm74	317	30	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	317	31	.	.	.
cord-015021-pol2qm74	318	1	Franco	Franco	NNP
cord-015021-pol2qm74	318	2	Di	Di	NNP
cord-015021-pol2qm74	318	3	Padova	Padova	NNP
cord-015021-pol2qm74	318	4	,	,	,
cord-015021-pol2qm74	318	5	SANDOZ	SANDOZ	NNP
cord-015021-pol2qm74	318	6	Pharma	Pharma	NNP
cord-015021-pol2qm74	318	7	AG	AG	NNP
cord-015021-pol2qm74	318	8	,	,	,
cord-015021-pol2qm74	318	9	CH4002	CH4002	NNP
cord-015021-pol2qm74	318	10	Basel	Basel	NNP
cord-015021-pol2qm74	318	11	,	,	,
cord-015021-pol2qm74	318	12	$	$	$
cord-015021-pol2qm74	318	13	chweiz	chweiz	NN
cord-015021-pol2qm74	318	14	$	$	$
cord-015021-pol2qm74	318	15	7	7	CD
cord-015021-pol2qm74	318	16	Presentation	Presentation	NNP
cord-015021-pol2qm74	318	17	of	of	IN
cord-015021-pol2qm74	318	18	LPS	LPS	NNP
cord-015021-pol2qm74	318	19	to	to	IN
cord-015021-pol2qm74	318	20	CD14	CD14	NNP
cord-015021-pol2qm74	318	21	by	by	IN
cord-015021-pol2qm74	318	22	LPS	LPS	NNP
cord-015021-pol2qm74	318	23	Binding	Binding	NNP
cord-015021-pol2qm74	318	24	Protein	Protein	NNP
cord-015021-pol2qm74	318	25	Peter	Peter	NNP
cord-015021-pol2qm74	318	26	S.	S.	NNP
cord-015021-pol2qm74	318	27	Tobias	Tobias	NNP
cord-015021-pol2qm74	318	28	,	,	,
cord-015021-pol2qm74	318	29	Julie	Julie	NNP
cord-015021-pol2qm74	318	30	Gegner	Gegner	NNP
cord-015021-pol2qm74	318	31	,	,	,
cord-015021-pol2qm74	318	32	Katrin	Katrin	NNP
cord-015021-pol2qm74	318	33	Soldau	Soldau	NNP
cord-015021-pol2qm74	318	34	,	,	,
cord-015021-pol2qm74	318	35	Lois	Lois	NNP
cord-015021-pol2qm74	318	36	Kline	Kline	NNP
cord-015021-pol2qm74	318	37	,	,	,
cord-015021-pol2qm74	318	38	Loren	Loren	NNP
cord-015021-pol2qm74	318	39	Hatlen	Hatlen	NNP
cord-015021-pol2qm74	318	40	,	,	,
cord-015021-pol2qm74	318	41	Douglas	Douglas	NNP
cord-015021-pol2qm74	318	42	Mintz	Mintz	NNP
cord-015021-pol2qm74	318	43	,	,	,
cord-015021-pol2qm74	318	44	and	and	CC
cord-015021-pol2qm74	318	45	Richard	Richard	NNP
cord-015021-pol2qm74	318	46	J.	J.	NNP
cord-015021-pol2qm74	318	47	Ulevitch	Ulevitch	NNP
cord-015021-pol2qm74	318	48	.	.	.
cord-015021-pol2qm74	319	1	The	the	DT
cord-015021-pol2qm74	319	2	activation	activation	NN
cord-015021-pol2qm74	319	3	of	of	IN
cord-015021-pol2qm74	319	4	myeloid	myeloid	NN
cord-015021-pol2qm74	319	5	cells	cell	NNS
cord-015021-pol2qm74	319	6	by	by	IN
cord-015021-pol2qm74	319	7	lipopolysaccharides	lipopolysaccharides	NNP
cord-015021-pol2qm74	319	8	(	(	-LRB-
cord-015021-pol2qm74	319	9	LPS	LPS	NNP
cord-015021-pol2qm74	319	10	)	)	-RRB-
cord-015021-pol2qm74	319	11	has	have	VBZ
cord-015021-pol2qm74	319	12	been	be	VBN
cord-015021-pol2qm74	319	13	shown	show	VBN
cord-015021-pol2qm74	319	14	to	to	TO
cord-015021-pol2qm74	319	15	require	require	VB
cord-015021-pol2qm74	319	16	the	the	DT
cord-015021-pol2qm74	319	17	serum	serum	NN
cord-015021-pol2qm74	319	18	glycoprotein	glycoprotein	NN
cord-015021-pol2qm74	319	19	LPS	LPS	NNP
cord-015021-pol2qm74	319	20	binding	bind	VBG
cord-015021-pol2qm74	319	21	protein	protein	NN
cord-015021-pol2qm74	319	22	(	(	-LRB-
cord-015021-pol2qm74	319	23	LBP	LBP	NNP
cord-015021-pol2qm74	319	24	)	)	-RRB-
cord-015021-pol2qm74	319	25	and	and	CC
cord-015021-pol2qm74	319	26	binding	binding	NN
cord-015021-pol2qm74	319	27	of	of	IN
cord-015021-pol2qm74	319	28	LPS	lp	NNS
cord-015021-pol2qm74	319	29	to	to	IN
cord-015021-pol2qm74	319	30	membrane	membrane	NN
cord-015021-pol2qm74	319	31	bound	bind	VBN
cord-015021-pol2qm74	319	32	CD14	CD14	NNP
cord-015021-pol2qm74	319	33	(	(	-LRB-
cord-015021-pol2qm74	319	34	mCD14	mCD14	NNP
cord-015021-pol2qm74	319	35	)	)	-RRB-
cord-015021-pol2qm74	319	36	.	.	.
cord-015021-pol2qm74	320	1	Other	other	JJ
cord-015021-pol2qm74	320	2	cells	cell	NNS
cord-015021-pol2qm74	320	3	such	such	JJ
cord-015021-pol2qm74	320	4	as	as	IN
cord-015021-pol2qm74	320	5	human	human	JJ
cord-015021-pol2qm74	320	6	umbilical	umbilical	JJ
cord-015021-pol2qm74	320	7	vein	vein	NN
cord-015021-pol2qm74	320	8	endothelial	endothelial	JJ
cord-015021-pol2qm74	320	9	cells	cell	NNS
cord-015021-pol2qm74	320	10	(	(	-LRB-
cord-015021-pol2qm74	320	11	HUVEC	HUVEC	NNP
cord-015021-pol2qm74	320	12	)	)	-RRB-
cord-015021-pol2qm74	320	13	,	,	,
cord-015021-pol2qm74	320	14	smooth	smooth	JJ
cord-015021-pol2qm74	320	15	muscle	muscle	NN
cord-015021-pol2qm74	320	16	cells	cell	NNS
cord-015021-pol2qm74	320	17	,	,	,
cord-015021-pol2qm74	320	18	and	and	CC
cord-015021-pol2qm74	320	19	some	some	DT
cord-015021-pol2qm74	320	20	epithelial	epithelial	JJ
cord-015021-pol2qm74	320	21	cells	cell	NNS
cord-015021-pol2qm74	320	22	,	,	,
cord-015021-pol2qm74	320	23	which	which	WDT
cord-015021-pol2qm74	320	24	do	do	VBP
cord-015021-pol2qm74	320	25	not	not	RB
cord-015021-pol2qm74	320	26	express	express	VB
cord-015021-pol2qm74	320	27	mCD14	mCD14	NNP
cord-015021-pol2qm74	320	28	but	but	CC
cord-015021-pol2qm74	320	29	nevertheless	nevertheless	RB
cord-015021-pol2qm74	320	30	respond	respond	VBZ
cord-015021-pol2qm74	320	31	to	to	IN
cord-015021-pol2qm74	320	32	LPS	LPS	NNP
cord-015021-pol2qm74	320	33	in	in	IN
cord-015021-pol2qm74	320	34	the	the	DT
cord-015021-pol2qm74	320	35	presence	presence	NN
cord-015021-pol2qm74	320	36	of	of	IN
cord-015021-pol2qm74	320	37	serum	serum	NN
cord-015021-pol2qm74	320	38	,	,	,
cord-015021-pol2qm74	320	39	have	have	VBP
cord-015021-pol2qm74	320	40	receptors	receptor	NNS
cord-015021-pol2qm74	320	41	for	for	IN
cord-015021-pol2qm74	320	42	complexes	complex	NNS
cord-015021-pol2qm74	320	43	of	of	IN
cord-015021-pol2qm74	320	44	LPS	lp	NNS
cord-015021-pol2qm74	320	45	with	with	IN
cord-015021-pol2qm74	320	46	the	the	DT
cord-015021-pol2qm74	320	47	soluble	soluble	JJ
cord-015021-pol2qm74	320	48	form	form	NN
cord-015021-pol2qm74	320	49	of	of	IN
cord-015021-pol2qm74	320	50	CD14	CD14	NNP
cord-015021-pol2qm74	320	51	(	(	-LRB-
cord-015021-pol2qm74	320	52	sCD14	sCD14	NNP
cord-015021-pol2qm74	320	53	)	)	-RRB-
cord-015021-pol2qm74	320	54	.	.	.
cord-015021-pol2qm74	321	1	These	these	DT
cord-015021-pol2qm74	321	2	complexes	complex	NNS
cord-015021-pol2qm74	321	3	of	of	IN
cord-015021-pol2qm74	321	4	LPS	LPS	NNP
cord-015021-pol2qm74	321	5	with	with	IN
cord-015021-pol2qm74	321	6	sCD14	sCD14	NNP
cord-015021-pol2qm74	321	7	are	be	VBP
cord-015021-pol2qm74	321	8	only	only	RB
cord-015021-pol2qm74	321	9	formed	form	VBN
cord-015021-pol2qm74	321	10	efficiently	efficiently	RB
cord-015021-pol2qm74	321	11	in	in	IN
cord-015021-pol2qm74	321	12	the	the	DT
cord-015021-pol2qm74	321	13	presence	presence	NN
cord-015021-pol2qm74	321	14	of	of	IN
cord-015021-pol2qm74	321	15	LBP	LBP	NNP
cord-015021-pol2qm74	321	16	.	.	.
cord-015021-pol2qm74	322	1	We	-PRON-	PRP
cord-015021-pol2qm74	322	2	have	have	VBP
cord-015021-pol2qm74	322	3	begun	begin	VBN
cord-015021-pol2qm74	322	4	to	to	TO
cord-015021-pol2qm74	322	5	characterise	characterise	VB
cord-015021-pol2qm74	322	6	the	the	DT
cord-015021-pol2qm74	322	7	mechanisms	mechanism	NNS
cord-015021-pol2qm74	322	8	by	by	IN
cord-015021-pol2qm74	322	9	which	which	WDT
cord-015021-pol2qm74	322	10	LBP	LBP	NNP
cord-015021-pol2qm74	322	11	enables	enable	VBZ
cord-015021-pol2qm74	322	12	LPS	lp	NNS
cord-015021-pol2qm74	322	13	to	to	TO
cord-015021-pol2qm74	322	14	bind	bind	VB
cord-015021-pol2qm74	322	15	to	to	IN
cord-015021-pol2qm74	322	16	CD14	CD14	NNP
cord-015021-pol2qm74	322	17	,	,	,
cord-015021-pol2qm74	322	18	either	either	CC
cord-015021-pol2qm74	322	19	soluble	soluble	JJ
cord-015021-pol2qm74	322	20	or	or	CC
cord-015021-pol2qm74	322	21	membrane	membrane	NN
cord-015021-pol2qm74	322	22	bound	bind	VBN
cord-015021-pol2qm74	322	23	.	.	.
cord-015021-pol2qm74	323	1	With	with	IN
cord-015021-pol2qm74	323	2	the	the	DT
cord-015021-pol2qm74	323	3	use	use	NN
cord-015021-pol2qm74	323	4	of	of	IN
cord-015021-pol2qm74	323	5	fluorophore	fluorophore	NN
cord-015021-pol2qm74	323	6	and	and	CC
cord-015021-pol2qm74	323	7	radiolabelled	radiolabelled	JJ
cord-015021-pol2qm74	323	8	reagents	reagent	NNS
cord-015021-pol2qm74	323	9	we	-PRON-	PRP
cord-015021-pol2qm74	323	10	have	have	VBP
cord-015021-pol2qm74	323	11	developed	develop	VBN
cord-015021-pol2qm74	323	12	procedures	procedure	NNS
cord-015021-pol2qm74	323	13	for	for	IN
cord-015021-pol2qm74	323	14	quantitative	quantitative	JJ
cord-015021-pol2qm74	323	15	measurement	measurement	NN
cord-015021-pol2qm74	323	16	of	of	IN
cord-015021-pol2qm74	323	17	the	the	DT
cord-015021-pol2qm74	323	18	association	association	NN
cord-015021-pol2qm74	323	19	of	of	IN
cord-015021-pol2qm74	323	20	LPS	LPS	NNP
cord-015021-pol2qm74	323	21	with	with	IN
cord-015021-pol2qm74	323	22	LBP	LBP	NNP
cord-015021-pol2qm74	323	23	and	and	CC
cord-015021-pol2qm74	323	24	of	of	IN
cord-015021-pol2qm74	323	25	LPS	LPS	NNP
cord-015021-pol2qm74	323	26	-	-	HYPH
cord-015021-pol2qm74	323	27	LBP	LBP	NNP
cord-015021-pol2qm74	323	28	complexes	complex	NNS
cord-015021-pol2qm74	323	29	with	with	IN
cord-015021-pol2qm74	323	30	CD14	CD14	NNP
cord-015021-pol2qm74	323	31	.	.	.
cord-015021-pol2qm74	324	1	These	these	DT
cord-015021-pol2qm74	324	2	results	result	NNS
cord-015021-pol2qm74	324	3	show	show	VBP
cord-015021-pol2qm74	324	4	that	that	IN
cord-015021-pol2qm74	324	5	the	the	DT
cord-015021-pol2qm74	324	6	delivery	delivery	NN
cord-015021-pol2qm74	324	7	of	of	IN
cord-015021-pol2qm74	324	8	LPS	lp	NNS
cord-015021-pol2qm74	324	9	to	to	IN
cord-015021-pol2qm74	324	10	sCD14	sCD14	NNP
cord-015021-pol2qm74	324	11	is	be	VBZ
cord-015021-pol2qm74	324	12	catalysed	catalyse	VBN
cord-015021-pol2qm74	324	13	by	by	IN
cord-015021-pol2qm74	324	14	LBP	LBP	NNP
cord-015021-pol2qm74	324	15	,	,	,
cord-015021-pol2qm74	324	16	i.e.	i.e.	FW
cord-015021-pol2qm74	324	17	,	,	,
cord-015021-pol2qm74	324	18	LBP	LBP	NNP
cord-015021-pol2qm74	324	19	is	be	VBZ
cord-015021-pol2qm74	324	20	not	not	RB
cord-015021-pol2qm74	324	21	included	include	VBN
cord-015021-pol2qm74	324	22	with	with	IN
cord-015021-pol2qm74	324	23	the	the	DT
cord-015021-pol2qm74	324	24	LPS	LPS	NNP
cord-015021-pol2qm74	324	25	-	-	HYPH
cord-015021-pol2qm74	324	26	sCD14	sCD14	NNP
cord-015021-pol2qm74	324	27	complex	complex	NN
cord-015021-pol2qm74	324	28	.	.	.
cord-015021-pol2qm74	325	1	In	in	IN
cord-015021-pol2qm74	325	2	contrast	contrast	NN
cord-015021-pol2qm74	325	3	,	,	,
cord-015021-pol2qm74	325	4	on	on	IN
cord-015021-pol2qm74	325	5	the	the	DT
cord-015021-pol2qm74	325	6	surface	surface	NN
cord-015021-pol2qm74	325	7	of	of	IN
cord-015021-pol2qm74	325	8	cells	cell	NNS
cord-015021-pol2qm74	325	9	,	,	,
cord-015021-pol2qm74	325	10	LBP	LBP	NNP
cord-015021-pol2qm74	325	11	does	do	VBZ
cord-015021-pol2qm74	325	12	not	not	RB
cord-015021-pol2qm74	325	13	dissociate	dissociate	VB
cord-015021-pol2qm74	325	14	from	from	IN
cord-015021-pol2qm74	325	15	the	the	DT
cord-015021-pol2qm74	325	16	cells	cell	NNS
cord-015021-pol2qm74	325	17	after	after	IN
cord-015021-pol2qm74	325	18	LPS	LPS	NNP
cord-015021-pol2qm74	325	19	binds	bind	VBZ
cord-015021-pol2qm74	325	20	to	to	IN
cord-015021-pol2qm74	325	21	mCD14	mCD14	NNP
cord-015021-pol2qm74	325	22	.	.	.
cord-015021-pol2qm74	326	1	The	the	DT
cord-015021-pol2qm74	326	2	kinetics	kinetic	NNS
cord-015021-pol2qm74	326	3	,	,	,
cord-015021-pol2qm74	326	4	equilibria	equilibrium	NNS
cord-015021-pol2qm74	326	5	and	and	CC
cord-015021-pol2qm74	326	6	stoichiometry	stoichiometry	NN
cord-015021-pol2qm74	326	7	of	of	IN
cord-015021-pol2qm74	326	8	these	these	DT
cord-015021-pol2qm74	326	9	reactions	reaction	NNS
cord-015021-pol2qm74	326	10	will	will	MD
cord-015021-pol2qm74	326	11	be	be	VB
cord-015021-pol2qm74	326	12	discussed	discuss	VBN
cord-015021-pol2qm74	326	13	in	in	IN
cord-015021-pol2qm74	326	14	the	the	DT
cord-015021-pol2qm74	326	15	context	context	NN
cord-015021-pol2qm74	326	16	of	of	IN
cord-015021-pol2qm74	326	17	models	model	NNS
cord-015021-pol2qm74	326	18	for	for	IN
cord-015021-pol2qm74	326	19	cellular	cellular	JJ
cord-015021-pol2qm74	326	20	activation	activation	NN
cord-015021-pol2qm74	326	21	by	by	IN
cord-015021-pol2qm74	326	22	LPS	LPS	NNP
cord-015021-pol2qm74	326	23	and	and	CC
cord-015021-pol2qm74	326	24	cellular	cellular	JJ
cord-015021-pol2qm74	326	25	uptake	uptake	NN
cord-015021-pol2qm74	326	26	of	of	IN
cord-015021-pol2qm74	326	27	LPS	LPS	NNP
cord-015021-pol2qm74	326	28	.	.	.
cord-015021-pol2qm74	327	1	Supported	support	VBN
cord-015021-pol2qm74	327	2	by	by	IN
cord-015021-pol2qm74	327	3	Nltt	Nltt	NNP
cord-015021-pol2qm74	327	4	grants	grant	NNS
cord-015021-pol2qm74	327	5	GM37696	gm37696	NN
cord-015021-pol2qm74	327	6	,	,	,
cord-015021-pol2qm74	327	7	AI32021	ai32021	NN
cord-015021-pol2qm74	327	8	,	,	,
cord-015021-pol2qm74	327	9	AI15136	AI15136	NNP
cord-015021-pol2qm74	327	10	,	,	,
cord-015021-pol2qm74	327	11	GM08172	GM08172	NNP
cord-015021-pol2qm74	327	12	,	,	,
cord-015021-pol2qm74	327	13	and	and	CC
cord-015021-pol2qm74	327	14	assistance	assistance	NN
cord-015021-pol2qm74	327	15	from	from	IN
cord-015021-pol2qm74	327	16	the	the	DT
cord-015021-pol2qm74	327	17	Pharmaceutical	Pharmaceutical	NNP
cord-015021-pol2qm74	327	18	Research	Research	NNP
cord-015021-pol2qm74	327	19	Institute	Institute	NNP
cord-015021-pol2qm74	327	20	of	of	IN
cord-015021-pol2qm74	327	21	Johnson	Johnson	NNP
cord-015021-pol2qm74	327	22	and	and	CC
cord-015021-pol2qm74	327	23	Johnson	Johnson	NNP
cord-015021-pol2qm74	327	24	.	.	.
cord-015021-pol2qm74	328	1	The	the	DT
cord-015021-pol2qm74	328	2	Scripps	Scripps	NNP
cord-015021-pol2qm74	328	3	Research	Research	NNP
cord-015021-pol2qm74	328	4	Institute	Institute	NNP
cord-015021-pol2qm74	328	5	,	,	,
cord-015021-pol2qm74	328	6	IMM-12	imm-12	CD
cord-015021-pol2qm74	328	7	,	,	,
cord-015021-pol2qm74	328	8	10666	10666	CD
cord-015021-pol2qm74	329	1	N.	N.	NNP
cord-015021-pol2qm74	329	2	Torrey	Torrey	NNP
cord-015021-pol2qm74	329	3	Pines	Pines	NNP
cord-015021-pol2qm74	329	4	Rd	Rd	NNP
cord-015021-pol2qm74	329	5	.	.	.
cord-015021-pol2qm74	329	6	La	La	NNP
cord-015021-pol2qm74	329	7	Jolla	Jolla	NNP
cord-015021-pol2qm74	329	8	,	,	,
cord-015021-pol2qm74	329	9	CA	CA	NNP
cord-015021-pol2qm74	329	10	USA	USA	NNP
cord-015021-pol2qm74	329	11	92037	92037	CD
cord-015021-pol2qm74	329	12	.	.	.
cord-015021-pol2qm74	330	1	Modulation	modulation	NN
cord-015021-pol2qm74	330	2	of	of	IN
cord-015021-pol2qm74	330	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	330	4	-	-	HYPH
cord-015021-pol2qm74	330	5	induced	induce	VBN
cord-015021-pol2qm74	330	6	cytokine	cytokine	NN
cord-015021-pol2qm74	330	7	production	production	NN
cord-015021-pol2qm74	330	8	by	by	IN
cord-015021-pol2qm74	330	9	LPS	LPS	NNP
cord-015021-pol2qm74	330	10	partial	partial	JJ
cord-015021-pol2qm74	330	11	structures	structure	NNS
cord-015021-pol2qm74	330	12	H.-D.	H.-D.	NNP
cord-015021-pol2qm74	330	13	Flad	Flad	NNP
cord-015021-pol2qm74	330	14	,	,	,
cord-015021-pol2qm74	330	15	H.	H.	NNP
cord-015021-pol2qm74	330	16	Loppnow	Loppnow	NNP
cord-015021-pol2qm74	330	17	,	,	,
cord-015021-pol2qm74	330	18	T.	T.	NNP
cord-015021-pol2qm74	330	19	Mattern	Mattern	NNP
cord-015021-pol2qm74	330	20	,	,	,
cord-015021-pol2qm74	330	21	and	and	CC
cord-015021-pol2qm74	330	22	A.J.	A.J.	NNP
cord-015021-pol2qm74	330	23	Ulmer	Ulmer	NNP
cord-015021-pol2qm74	330	24	Department	Department	NNP
cord-015021-pol2qm74	330	25	of	of	IN
cord-015021-pol2qm74	330	26	Immunology	Immunology	NNP
cord-015021-pol2qm74	330	27	and	and	CC
cord-015021-pol2qm74	330	28	Cell	Cell	NNP
cord-015021-pol2qm74	330	29	Biology	Biology	NNP
cord-015021-pol2qm74	330	30	,	,	,
cord-015021-pol2qm74	330	31	Forschungsinstitut	Forschungsinstitut	NNP
cord-015021-pol2qm74	330	32	Borstel	Borstel	NNP
cord-015021-pol2qm74	330	33	,	,	,
cord-015021-pol2qm74	330	34	D-23845	d-23845	NN
cord-015021-pol2qm74	331	1	Borstel	Borstel	NNP
cord-015021-pol2qm74	331	2	Lipid	Lipid	NNP
cord-015021-pol2qm74	331	3	A	A	NNP
cord-015021-pol2qm74	331	4	constitutes	constitute	VBZ
cord-015021-pol2qm74	331	5	the	the	DT
cord-015021-pol2qm74	331	6	active	active	JJ
cord-015021-pol2qm74	331	7	moiety	moiety	NN
cord-015021-pol2qm74	331	8	of	of	IN
cord-015021-pol2qm74	331	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	331	10	(	(	-LRB-
cord-015021-pol2qm74	331	11	LPS	LPS	NNP
cord-015021-pol2qm74	331	12	)	)	-RRB-
cord-015021-pol2qm74	331	13	of	of	IN
cord-015021-pol2qm74	331	14	Gramnegative	Gramnegative	NNP
cord-015021-pol2qm74	331	15	bacteria	bacteria	NNS
cord-015021-pol2qm74	331	16	.	.	.
cord-015021-pol2qm74	332	1	It	-PRON-	PRP
cord-015021-pol2qm74	332	2	activates	activate	VBZ
cord-015021-pol2qm74	332	3	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	332	4	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	332	5	to	to	TO
cord-015021-pol2qm74	332	6	produce	produce	VB
cord-015021-pol2qm74	332	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	332	8	,	,	,
cord-015021-pol2qm74	332	9	such	such	JJ
cord-015021-pol2qm74	332	10	as	as	IN
cord-015021-pol2qm74	332	11	TNF	TNF	NNP
cord-015021-pol2qm74	332	12	,	,	,
cord-015021-pol2qm74	332	13	I1_-1	I1_-1	NNP
cord-015021-pol2qm74	332	14	,	,	,
cord-015021-pol2qm74	332	15	and	and	CC
cord-015021-pol2qm74	332	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	332	17	,	,	,
cord-015021-pol2qm74	332	18	which	which	WDT
cord-015021-pol2qm74	332	19	are	be	VBP
cord-015021-pol2qm74	332	20	the	the	DT
cord-015021-pol2qm74	332	21	major	major	JJ
cord-015021-pol2qm74	332	22	mediators	mediator	NNS
cord-015021-pol2qm74	332	23	of	of	IN
cord-015021-pol2qm74	332	24	the	the	DT
cord-015021-pol2qm74	332	25	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	332	26	effect	effect	NN
cord-015021-pol2qm74	332	27	of	of	IN
cord-015021-pol2qm74	332	28	LPS	LPS	NNP
cord-015021-pol2qm74	332	29	in	in	IN
cord-015021-pol2qm74	332	30	vivo	vivo	NN
cord-015021-pol2qm74	332	31	.	.	.
cord-015021-pol2qm74	333	1	Lipid	Lipid	NNP
cord-015021-pol2qm74	333	2	A	a	DT
cord-015021-pol2qm74	333	3	precursor	precursor	NN
cord-015021-pol2qm74	333	4	la	la	FW
cord-015021-pol2qm74	333	5	(	(	-LRB-
cord-015021-pol2qm74	333	6	synthetic	synthetic	JJ
cord-015021-pol2qm74	333	7	compound	compound	NN
cord-015021-pol2qm74	333	8	406	406	CD
cord-015021-pol2qm74	333	9	)	)	-RRB-
cord-015021-pol2qm74	333	10	does	do	VBZ
cord-015021-pol2qm74	333	11	not	not	RB
cord-015021-pol2qm74	333	12	induce	induce	VB
cord-015021-pol2qm74	333	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	333	14	,	,	,
cord-015021-pol2qm74	333	15	but	but	CC
cord-015021-pol2qm74	333	16	is	be	VBZ
cord-015021-pol2qm74	333	17	able	able	JJ
cord-015021-pol2qm74	333	18	to	to	TO
cord-015021-pol2qm74	333	19	specifically	specifically	RB
cord-015021-pol2qm74	333	20	antagonize	antagonize	VB
cord-015021-pol2qm74	333	21	LPS	LPS	NNP
cord-015021-pol2qm74	333	22	-	-	:
cord-015021-pol2qm74	333	23	or	or	CC
cord-015021-pol2qm74	333	24	lipid	lipid	NN
cord-015021-pol2qm74	333	25	A	a	NN
cord-015021-pol2qm74	333	26	-	-	HYPH
cord-015021-pol2qm74	333	27	induced	induce	VBN
cord-015021-pol2qm74	333	28	mediator	mediator	NN
cord-015021-pol2qm74	333	29	production	production	NN
cord-015021-pol2qm74	333	30	in	in	IN
cord-015021-pol2qm74	333	31	human	human	JJ
cord-015021-pol2qm74	333	32	mononuclear	mononuclear	NN
cord-015021-pol2qm74	333	33	cells	cell	NNS
cord-015021-pol2qm74	333	34	,	,	,
cord-015021-pol2qm74	333	35	vascular	vascular	JJ
cord-015021-pol2qm74	333	36	endothelial	endothelial	JJ
cord-015021-pol2qm74	333	37	cells	cell	NNS
cord-015021-pol2qm74	333	38	,	,	,
cord-015021-pol2qm74	333	39	and	and	CC
cord-015021-pol2qm74	333	40	smooth	smooth	JJ
cord-015021-pol2qm74	333	41	muscle	muscle	NN
cord-015021-pol2qm74	333	42	cells	cell	NNS
cord-015021-pol2qm74	333	43	.	.	.
cord-015021-pol2qm74	334	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	334	2	,	,	,
cord-015021-pol2qm74	334	3	we	-PRON-	PRP
cord-015021-pol2qm74	334	4	present	present	VBP
cord-015021-pol2qm74	334	5	evidence	evidence	NN
cord-015021-pol2qm74	334	6	for	for	IN
cord-015021-pol2qm74	334	7	the	the	DT
cord-015021-pol2qm74	334	8	first	first	JJ
cord-015021-pol2qm74	334	9	time	time	NN
cord-015021-pol2qm74	334	10	that	that	WDT
cord-015021-pol2qm74	334	11	T	t	NN
cord-015021-pol2qm74	334	12	-	-	HYPH
cord-015021-pol2qm74	334	13	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	334	14	proliferate	proliferate	VBP
cord-015021-pol2qm74	334	15	in	in	IN
cord-015021-pol2qm74	334	16	response	response	NN
cord-015021-pol2qm74	334	17	to	to	IN
cord-015021-pol2qm74	334	18	LPS	LPS	NNP
cord-015021-pol2qm74	334	19	and	and	CC
cord-015021-pol2qm74	334	20	express	express	VB
cord-015021-pol2qm74	334	21	mRNA	mrna	NN
cord-015021-pol2qm74	334	22	for	for	IN
cord-015021-pol2qm74	334	23	interleukin-2	interleukin-2	NNP
cord-015021-pol2qm74	334	24	and	and	CC
cord-015021-pol2qm74	334	25	interferon-~	interferon-~	NNP
cord-015021-pol2qm74	334	26	and	and	CC
cord-015021-pol2qm74	334	27	that	that	IN
cord-015021-pol2qm74	334	28	these	these	DT
cord-015021-pol2qm74	334	29	responses	response	NNS
cord-015021-pol2qm74	334	30	are	be	VBP
cord-015021-pol2qm74	334	31	also	also	RB
cord-015021-pol2qm74	334	32	antagonized	antagonize	VBN
cord-015021-pol2qm74	334	33	by	by	IN
cord-015021-pol2qm74	334	34	synthetic	synthetic	JJ
cord-015021-pol2qm74	334	35	lipid	lipid	NN
cord-015021-pol2qm74	334	36	A	a	DT
cord-015021-pol2qm74	334	37	precursor	precursor	NN
cord-015021-pol2qm74	334	38	la	la	NN
cord-015021-pol2qm74	334	39	.	.	.
cord-015021-pol2qm74	335	1	When	when	WRB
cord-015021-pol2qm74	335	2	comparing	compare	VBG
cord-015021-pol2qm74	335	3	the	the	DT
cord-015021-pol2qm74	335	4	agonistic	agonistic	JJ
cord-015021-pol2qm74	335	5	and	and	CC
cord-015021-pol2qm74	335	6	antagonistic	antagonistic	JJ
cord-015021-pol2qm74	335	7	activity	activity	NN
cord-015021-pol2qm74	335	8	of	of	IN
cord-015021-pol2qm74	335	9	lipid	lipid	NN
cord-015021-pol2qm74	335	10	A	a	NN
cord-015021-pol2qm74	335	11	and	and	CC
cord-015021-pol2qm74	335	12	different	different	JJ
cord-015021-pol2qm74	335	13	partial	partial	JJ
cord-015021-pol2qm74	335	14	structures	structure	NNS
cord-015021-pol2qm74	335	15	at	at	IN
cord-015021-pol2qm74	335	16	the	the	DT
cord-015021-pol2qm74	335	17	functional	functional	JJ
cord-015021-pol2qm74	335	18	and	and	CC
cord-015021-pol2qm74	335	19	binding	binding	JJ
cord-015021-pol2qm74	335	20	level	level	NN
cord-015021-pol2qm74	335	21	,	,	,
cord-015021-pol2qm74	335	22	the	the	DT
cord-015021-pol2qm74	335	23	number	number	NN
cord-015021-pol2qm74	335	24	and	and	CC
cord-015021-pol2qm74	335	25	length	length	NN
cord-015021-pol2qm74	335	26	of	of	IN
cord-015021-pol2qm74	335	27	the	the	DT
cord-015021-pol2qm74	335	28	fatty	fatty	JJ
cord-015021-pol2qm74	335	29	acids	acid	NNS
cord-015021-pol2qm74	335	30	and	and	CC
cord-015021-pol2qm74	335	31	the	the	DT
cord-015021-pol2qm74	335	32	number	number	NN
cord-015021-pol2qm74	335	33	of	of	IN
cord-015021-pol2qm74	335	34	phosphoryl	phosphoryl	NNP
cord-015021-pol2qm74	335	35	groups	group	NNS
cord-015021-pol2qm74	335	36	were	be	VBD
cord-015021-pol2qm74	335	37	Pound	pound	NN
cord-015021-pol2qm74	335	38	to	to	TO
cord-015021-pol2qm74	335	39	be	be	VB
cord-015021-pol2qm74	335	40	of	of	IN
cord-015021-pol2qm74	335	41	crucial	crucial	JJ
cord-015021-pol2qm74	335	42	importance	importance	NN
cord-015021-pol2qm74	335	43	.	.	.
cord-015021-pol2qm74	336	1	Unexpectedly	unexpectedly	RB
cord-015021-pol2qm74	336	2	,	,	,
cord-015021-pol2qm74	336	3	lipid	lipid	VBG
cord-015021-pol2qm74	336	4	A	a	DT
cord-015021-pol2qm74	336	5	precursor	precursor	NN
cord-015021-pol2qm74	336	6	la	la	NN
cord-015021-pol2qm74	336	7	,	,	,
cord-015021-pol2qm74	336	8	although	although	IN
cord-015021-pol2qm74	336	9	biologically	biologically	RB
cord-015021-pol2qm74	336	10	inactive	inactive	JJ
cord-015021-pol2qm74	336	11	,	,	,
cord-015021-pol2qm74	336	12	turned	turn	VBD
cord-015021-pol2qm74	336	13	out	out	RP
cord-015021-pol2qm74	336	14	to	to	TO
cord-015021-pol2qm74	336	15	be	be	VB
cord-015021-pol2qm74	336	16	both	both	CC
cord-015021-pol2qm74	336	17	the	the	DT
cord-015021-pol2qm74	336	18	most	most	RBS
cord-015021-pol2qm74	336	19	potent	potent	JJ
cord-015021-pol2qm74	336	20	antagonist	antagonist	NN
cord-015021-pol2qm74	336	21	and	and	CC
cord-015021-pol2qm74	336	22	competitor	competitor	NN
cord-015021-pol2qm74	336	23	in	in	IN
cord-015021-pol2qm74	336	24	inhibiting	inhibit	VBG
cord-015021-pol2qm74	336	25	the	the	DT
cord-015021-pol2qm74	336	26	binding	binding	NN
cord-015021-pol2qm74	336	27	of	of	IN
cord-015021-pol2qm74	336	28	LPS	lp	NNS
cord-015021-pol2qm74	336	29	.	.	.
cord-015021-pol2qm74	337	1	Taken	take	VBN
cord-015021-pol2qm74	337	2	together	together	RB
cord-015021-pol2qm74	337	3	,	,	,
cord-015021-pol2qm74	337	4	our	-PRON-	PRP$
cord-015021-pol2qm74	337	5	results	result	NNS
cord-015021-pol2qm74	337	6	provide	provide	VBP
cord-015021-pol2qm74	337	7	evidence	evidence	NN
cord-015021-pol2qm74	337	8	for	for	IN
cord-015021-pol2qm74	337	9	a	a	DT
cord-015021-pol2qm74	337	10	model	model	NN
cord-015021-pol2qm74	337	11	in	in	IN
cord-015021-pol2qm74	337	12	which	which	WDT
cord-015021-pol2qm74	337	13	lipid	lipid	NN
cord-015021-pol2qm74	337	14	A	a	DT
cord-015021-pol2qm74	337	15	partial	partial	JJ
cord-015021-pol2qm74	337	16	structures	structure	NNS
cord-015021-pol2qm74	337	17	compete	compete	VBP
cord-015021-pol2qm74	337	18	with	with	IN
cord-015021-pol2qm74	337	19	LPS	lp	NNS
cord-015021-pol2qm74	337	20	for	for	IN
cord-015021-pol2qm74	337	21	specific	specific	JJ
cord-015021-pol2qm74	337	22	cell	cell	NN
cord-015021-pol2qm74	337	23	surface	surface	NN
cord-015021-pol2qm74	337	24	receptor(s	receptor(s	NNP
cord-015021-pol2qm74	337	25	)	)	-RRB-
cord-015021-pol2qm74	337	26	.	.	.
cord-015021-pol2qm74	338	1	In	in	IN
cord-015021-pol2qm74	338	2	this	this	DT
cord-015021-pol2qm74	338	3	sense	sense	NN
cord-015021-pol2qm74	338	4	,	,	,
cord-015021-pol2qm74	338	5	biologically	biologically	RB
cord-015021-pol2qm74	338	6	inactive	inactive	JJ
cord-015021-pol2qm74	338	7	lipid	lipid	NN
cord-015021-pol2qm74	338	8	A	a	DT
cord-015021-pol2qm74	338	9	analogues	analogue	NNS
cord-015021-pol2qm74	338	10	may	may	MD
cord-015021-pol2qm74	338	11	be	be	VB
cord-015021-pol2qm74	338	12	good	good	JJ
cord-015021-pol2qm74	338	13	candidates	candidate	NNS
cord-015021-pol2qm74	338	14	as	as	IN
cord-015021-pol2qm74	338	15	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	338	16	agents	agent	NNS
cord-015021-pol2qm74	338	17	for	for	IN
cord-015021-pol2qm74	338	18	the	the	DT
cord-015021-pol2qm74	338	19	prevention	prevention	NN
cord-015021-pol2qm74	338	20	of	of	IN
cord-015021-pol2qm74	338	21	Gram	gram	NN
cord-015021-pol2qm74	338	22	-	-	HYPH
cord-015021-pol2qm74	338	23	negative	negative	JJ
cord-015021-pol2qm74	338	24	septic	septic	JJ
cord-015021-pol2qm74	338	25	shock	shock	NN
cord-015021-pol2qm74	338	26	.	.	.
cord-015021-pol2qm74	339	1	Two	two	CD
cord-015021-pol2qm74	339	2	mammalian	mammalian	JJ
cord-015021-pol2qm74	339	3	lipid	lipid	NN
cord-015021-pol2qm74	339	4	A	a	NN
cord-015021-pol2qm74	339	5	-	-	HYPH
cord-015021-pol2qm74	339	6	binding	bind	VBG
cord-015021-pol2qm74	339	7	proteins	protein	NNS
cord-015021-pol2qm74	339	8	have	have	VBP
cord-015021-pol2qm74	339	9	been	be	VBN
cord-015021-pol2qm74	339	10	identified	identify	VBN
cord-015021-pol2qm74	339	11	that	that	WDT
cord-015021-pol2qm74	339	12	are	be	VBP
cord-015021-pol2qm74	339	13	believed	believe	VBN
cord-015021-pol2qm74	339	14	to	to	TO
cord-015021-pol2qm74	339	15	have	have	VB
cord-015021-pol2qm74	339	16	important	important	JJ
cord-015021-pol2qm74	339	17	roles	role	NNS
cord-015021-pol2qm74	339	18	in	in	IN
cord-015021-pol2qm74	339	19	mediating	mediate	VBG
cord-015021-pol2qm74	339	20	the	the	DT
cord-015021-pol2qm74	339	21	host	host	NN
cord-015021-pol2qm74	339	22	response	response	NN
cord-015021-pol2qm74	339	23	to	to	IN
cord-015021-pol2qm74	339	24	endotoxin	endotoxin	NN
cord-015021-pol2qm74	339	25	:	:	:
cord-015021-pol2qm74	339	26	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	339	27	-	-	HYPH
cord-015021-pol2qm74	339	28	binding	bind	VBG
cord-015021-pol2qm74	339	29	protein	protein	NN
cord-015021-pol2qm74	339	30	(	(	-LRB-
cord-015021-pol2qm74	339	31	LBP	LBP	NNP
cord-015021-pol2qm74	339	32	)	)	-RRB-
cord-015021-pol2qm74	339	33	and	and	CC
cord-015021-pol2qm74	339	34	bactericidal/	bactericidal/	CD
cord-015021-pol2qm74	339	35	permeability	permeability	NN
cord-015021-pol2qm74	339	36	-	-	HYPH
cord-015021-pol2qm74	339	37	increasing	increase	VBG
cord-015021-pol2qm74	339	38	protein	protein	NN
cord-015021-pol2qm74	339	39	(	(	-LRB-
cord-015021-pol2qm74	339	40	BPI	BPI	NNP
cord-015021-pol2qm74	339	41	)	)	-RRB-
cord-015021-pol2qm74	339	42	.	.	.
cord-015021-pol2qm74	340	1	Human	human	JJ
cord-015021-pol2qm74	340	2	LBP	LBP	NNP
cord-015021-pol2qm74	340	3	shares	share	VBZ
cord-015021-pol2qm74	340	4	a	a	DT
cord-015021-pol2qm74	340	5	45	45	CD
cord-015021-pol2qm74	340	6	%	%	NN
cord-015021-pol2qm74	340	7	amino	amino	NN
cord-015021-pol2qm74	340	8	acid	acid	NN
cord-015021-pol2qm74	340	9	sequence	sequence	NN
cord-015021-pol2qm74	340	10	identity	identity	NN
cord-015021-pol2qm74	340	11	with	with	IN
cord-015021-pol2qm74	340	12	human	human	JJ
cord-015021-pol2qm74	340	13	BPI	BPI	NNP
cord-015021-pol2qm74	340	14	.	.	.
cord-015021-pol2qm74	341	1	Despite	despite	IN
cord-015021-pol2qm74	341	2	the	the	DT
cord-015021-pol2qm74	341	3	sequence	sequence	NN
cord-015021-pol2qm74	341	4	homology	homology	NN
cord-015021-pol2qm74	341	5	,	,	,
cord-015021-pol2qm74	341	6	the	the	DT
cord-015021-pol2qm74	341	7	two	two	CD
cord-015021-pol2qm74	341	8	lipid	lipid	NN
cord-015021-pol2qm74	341	9	A	a	NN
cord-015021-pol2qm74	341	10	-	-	HYPH
cord-015021-pol2qm74	341	11	binding	bind	VBG
cord-015021-pol2qm74	341	12	proteins	protein	NNS
cord-015021-pol2qm74	341	13	have	have	VBP
cord-015021-pol2qm74	341	14	very	very	RB
cord-015021-pol2qm74	341	15	different	different	JJ
cord-015021-pol2qm74	341	16	functional	functional	JJ
cord-015021-pol2qm74	341	17	activities	activity	NNS
cord-015021-pol2qm74	341	18	.	.	.
cord-015021-pol2qm74	342	1	LBP	LBP	NNP
cord-015021-pol2qm74	342	2	is	be	VBZ
cord-015021-pol2qm74	342	3	an	an	DT
cord-015021-pol2qm74	342	4	acute	acute	JJ
cord-015021-pol2qm74	342	5	phase	phase	NN
cord-015021-pol2qm74	342	6	serum	serum	NN
cord-015021-pol2qm74	342	7	protein	protein	NN
cord-015021-pol2qm74	342	8	that	that	WDT
cord-015021-pol2qm74	342	9	markedly	markedly	RB
cord-015021-pol2qm74	342	10	potentiates	potentiate	VBZ
cord-015021-pol2qm74	342	11	the	the	DT
cord-015021-pol2qm74	342	12	proinfiammatory	proinfiammatory	NNP
cord-015021-pol2qm74	342	13	host	host	NN
cord-015021-pol2qm74	342	14	response	response	NN
cord-015021-pol2qm74	342	15	to	to	IN
cord-015021-pol2qm74	342	16	gram	gram	JJ
cord-015021-pol2qm74	342	17	-	-	HYPH
cord-015021-pol2qm74	342	18	negative	negative	JJ
cord-015021-pol2qm74	342	19	infection	infection	NN
cord-015021-pol2qm74	342	20	by	by	IN
cord-015021-pol2qm74	342	21	a	a	DT
cord-015021-pol2qm74	342	22	mechanism	mechanism	NN
cord-015021-pol2qm74	342	23	which	which	WDT
cord-015021-pol2qm74	342	24	involves	involve	VBZ
cord-015021-pol2qm74	342	25	binding	binding	NN
cord-015021-pol2qm74	342	26	of	of	IN
cord-015021-pol2qm74	342	27	the	the	DT
cord-015021-pol2qm74	342	28	LBP	LBP	NNP
cord-015021-pol2qm74	342	29	-	-	HYPH
cord-015021-pol2qm74	342	30	LPS	LPS	NNP
cord-015021-pol2qm74	342	31	complex	complex	NN
cord-015021-pol2qm74	342	32	to	to	IN
cord-015021-pol2qm74	342	33	CD14	CD14	NNP
cord-015021-pol2qm74	342	34	receptors	receptor	NNS
cord-015021-pol2qm74	342	35	on	on	IN
cord-015021-pol2qm74	342	36	monocytes	monocyte	NNS
cord-015021-pol2qm74	342	37	,	,	,
cord-015021-pol2qm74	342	38	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	342	39	and	and	CC
cord-015021-pol2qm74	342	40	endothelial	endothelial	JJ
cord-015021-pol2qm74	342	41	cells	cell	NNS
cord-015021-pol2qm74	342	42	.	.	.
cord-015021-pol2qm74	343	1	In	in	IN
cord-015021-pol2qm74	343	2	contrast	contrast	NN
cord-015021-pol2qm74	343	3	,	,	,
cord-015021-pol2qm74	343	4	BPI	BPI	NNP
cord-015021-pol2qm74	343	5	is	be	VBZ
cord-015021-pol2qm74	343	6	a	a	DT
cord-015021-pol2qm74	343	7	neutrophil	neutrophil	NN
cord-015021-pol2qm74	343	8	granule	granule	NN
cord-015021-pol2qm74	343	9	protein	protein	NN
cord-015021-pol2qm74	343	10	with	with	IN
cord-015021-pol2qm74	343	11	potent	potent	JJ
cord-015021-pol2qm74	343	12	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	343	13	and	and	CC
cord-015021-pol2qm74	343	14	LPS	lps	NN
cord-015021-pol2qm74	343	15	-	-	HYPH
cord-015021-pol2qm74	343	16	neutralizing	neutralize	VBG
cord-015021-pol2qm74	343	17	activities	activity	NNS
cord-015021-pol2qm74	343	18	.	.	.
cord-015021-pol2qm74	344	1	The	the	DT
cord-015021-pol2qm74	344	2	divergent	divergent	JJ
cord-015021-pol2qm74	344	3	functional	functional	JJ
cord-015021-pol2qm74	344	4	properties	property	NNS
cord-015021-pol2qm74	344	5	of	of	IN
cord-015021-pol2qm74	344	6	these	these	DT
cord-015021-pol2qm74	344	7	two	two	CD
cord-015021-pol2qm74	344	8	LPS	LPS	NNP
cord-015021-pol2qm74	344	9	-	-	HYPH
cord-015021-pol2qm74	344	10	bindlng	bindlng	NN
cord-015021-pol2qm74	344	11	proteins	protein	NNS
cord-015021-pol2qm74	344	12	can	can	MD
cord-015021-pol2qm74	344	13	be	be	VB
cord-015021-pol2qm74	344	14	explained	explain	VBN
cord-015021-pol2qm74	344	15	by	by	IN
cord-015021-pol2qm74	344	16	the	the	DT
cord-015021-pol2qm74	344	17	inability	inability	NN
cord-015021-pol2qm74	344	18	of	of	IN
cord-015021-pol2qm74	344	19	BPI	BPI	NNP
cord-015021-pol2qm74	344	20	-	-	HYPH
cord-015021-pol2qm74	344	21	LPS	LPS	NNP
cord-015021-pol2qm74	344	22	complexes	complex	NNS
cord-015021-pol2qm74	344	23	to	to	TO
cord-015021-pol2qm74	344	24	bind	bind	VB
cord-015021-pol2qm74	344	25	to	to	IN
cord-015021-pol2qm74	344	26	cell	cell	NN
cord-015021-pol2qm74	344	27	-	-	HYPH
cord-015021-pol2qm74	344	28	surface	surface	NN
cord-015021-pol2qm74	344	29	CD14	CD14	NNP
cord-015021-pol2qm74	344	30	receptors	receptor	NNS
cord-015021-pol2qm74	344	31	.	.	.
cord-015021-pol2qm74	345	1	A	a	DT
cord-015021-pol2qm74	345	2	recombinant	recombinant	JJ
cord-015021-pol2qm74	345	3	protein	protein	NN
cord-015021-pol2qm74	345	4	(	(	-LRB-
cord-015021-pol2qm74	345	5	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	345	6	)	)	-RRB-
cord-015021-pol2qm74	345	7	,	,	,
cord-015021-pol2qm74	345	8	corresponding	correspond	VBG
cord-015021-pol2qm74	345	9	to	to	IN
cord-015021-pol2qm74	345	10	the	the	DT
cord-015021-pol2qm74	345	11	amino	amino	NN
cord-015021-pol2qm74	345	12	terminal	terminal	NN
cord-015021-pol2qm74	345	13	23kD	23kd	CD
cord-015021-pol2qm74	345	14	fragment	fragment	NN
cord-015021-pol2qm74	345	15	of	of	IN
cord-015021-pol2qm74	345	16	human	human	JJ
cord-015021-pol2qm74	345	17	BPI	BPI	NNP
cord-015021-pol2qm74	345	18	,	,	,
cord-015021-pol2qm74	345	19	has	have	VBZ
cord-015021-pol2qm74	345	20	been	be	VBN
cord-015021-pol2qm74	345	21	shown	show	VBN
cord-015021-pol2qm74	345	22	to	to	TO
cord-015021-pol2qm74	345	23	retain	retain	VB
cord-015021-pol2qm74	345	24	the	the	DT
cord-015021-pol2qm74	345	25	potent	potent	JJ
cord-015021-pol2qm74	345	26	biological	biological	JJ
cord-015021-pol2qm74	345	27	activities	activity	NNS
cord-015021-pol2qm74	345	28	of	of	IN
cord-015021-pol2qm74	345	29	the	the	DT
cord-015021-pol2qm74	345	30	hdlo	hdlo	NN
cord-015021-pol2qm74	345	31	protein	protein	NN
cord-015021-pol2qm74	345	32	and	and	CC
cord-015021-pol2qm74	345	33	may	may	MD
cord-015021-pol2qm74	345	34	represent	represent	VB
cord-015021-pol2qm74	345	35	a	a	DT
cord-015021-pol2qm74	345	36	novel	novel	JJ
cord-015021-pol2qm74	345	37	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	345	38	agent	agent	NN
cord-015021-pol2qm74	345	39	for	for	IN
cord-015021-pol2qm74	345	40	the	the	DT
cord-015021-pol2qm74	345	41	treatment	treatment	NN
cord-015021-pol2qm74	345	42	of	of	IN
cord-015021-pol2qm74	345	43	gram	gram	NN
cord-015021-pol2qm74	345	44	-	-	HYPH
cord-015021-pol2qm74	345	45	negative	negative	JJ
cord-015021-pol2qm74	345	46	infections	infection	NNS
cord-015021-pol2qm74	345	47	,	,	,
cord-015021-pol2qm74	345	48	sepsis	sepsis	NN
cord-015021-pol2qm74	345	49	and	and	CC
cord-015021-pol2qm74	345	50	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	345	51	.	.	.
cord-015021-pol2qm74	346	1	For	for	IN
cord-015021-pol2qm74	346	2	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	346	3	effectiveness	effectiveness	NN
cord-015021-pol2qm74	346	4	in	in	IN
cord-015021-pol2qm74	346	5	many	many	JJ
cord-015021-pol2qm74	346	6	clinical	clinical	JJ
cord-015021-pol2qm74	346	7	situations	situation	NNS
cord-015021-pol2qm74	346	8	,	,	,
cord-015021-pol2qm74	346	9	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	346	10	will	will	MD
cord-015021-pol2qm74	346	11	have	have	VB
cord-015021-pol2qm74	346	12	to	to	TO
cord-015021-pol2qm74	346	13	successfully	successfully	RB
cord-015021-pol2qm74	346	14	compete	compete	VB
cord-015021-pol2qm74	346	15	with	with	IN
cord-015021-pol2qm74	346	16	relatively	relatively	RB
cord-015021-pol2qm74	346	17	high	high	JJ
cord-015021-pol2qm74	346	18	serum	serum	NN
cord-015021-pol2qm74	346	19	levels	level	NNS
cord-015021-pol2qm74	346	20	of	of	IN
cord-015021-pol2qm74	346	21	LBP	LBP	NNP
cord-015021-pol2qm74	346	22	(	(	-LRB-
cord-015021-pol2qm74	346	23	5	5	CD
cord-015021-pol2qm74	346	24	-	-	SYM
cord-015021-pol2qm74	346	25	60	60	CD
cord-015021-pol2qm74	346	26	~g	~g	NNP
cord-015021-pol2qm74	346	27	/	/	SYM
cord-015021-pol2qm74	346	28	mI	mI	NNP
cord-015021-pol2qm74	346	29	)	)	-RRB-
cord-015021-pol2qm74	346	30	for	for	IN
cord-015021-pol2qm74	346	31	binding	bind	VBG
cord-015021-pol2qm74	346	32	to	to	IN
cord-015021-pol2qm74	346	33	endotoxin	endotoxin	NN
cord-015021-pol2qm74	346	34	and	and	CC
cord-015021-pol2qm74	346	35	gram	gram	NN
cord-015021-pol2qm74	346	36	-	-	HYPH
cord-015021-pol2qm74	346	37	negative	negative	JJ
cord-015021-pol2qm74	346	38	bacteria	bacteria	NNS
cord-015021-pol2qm74	346	39	.	.	.
cord-015021-pol2qm74	347	1	To	to	TO
cord-015021-pol2qm74	347	2	evaluate	evaluate	VB
cord-015021-pol2qm74	347	3	this	this	DT
cord-015021-pol2qm74	347	4	issue	issue	NN
cord-015021-pol2qm74	347	5	,	,	,
cord-015021-pol2qm74	347	6	experiments	experiment	NNS
cord-015021-pol2qm74	347	7	were	be	VBD
cord-015021-pol2qm74	347	8	conducted	conduct	VBN
cord-015021-pol2qm74	347	9	to	to	TO
cord-015021-pol2qm74	347	10	compare	compare	VB
cord-015021-pol2qm74	347	11	the	the	DT
cord-015021-pol2qm74	347	12	relative	relative	JJ
cord-015021-pol2qm74	347	13	binding	bind	VBG
cord-015021-pol2qm74	347	14	affinities	affinity	NNS
cord-015021-pol2qm74	347	15	of	of	IN
cord-015021-pol2qm74	347	16	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	347	17	and	and	CC
cord-015021-pol2qm74	347	18	human	human	JJ
cord-015021-pol2qm74	347	19	recombinant	recombinant	JJ
cord-015021-pol2qm74	347	20	LBP	LBP	NNP
cord-015021-pol2qm74	347	21	(	(	-LRB-
cord-015021-pol2qm74	347	22	rLBP	rlbp	IN
cord-015021-pol2qm74	347	23	)	)	-RRB-
cord-015021-pol2qm74	347	24	for	for	IN
cord-015021-pol2qm74	347	25	lipid	lipid	NN
cord-015021-pol2qm74	347	26	A.	a.	NN
cord-015021-pol2qm74	348	1	The	the	DT
cord-015021-pol2qm74	348	2	binding	binding	NN
cord-015021-pol2qm74	348	3	of	of	IN
cord-015021-pol2qm74	348	4	both	both	DT
cord-015021-pol2qm74	348	5	proteins	protein	NNS
cord-015021-pol2qm74	348	6	to	to	IN
cord-015021-pol2qm74	348	7	Iipid	Iipid	NNP
cord-015021-pol2qm74	348	8	A	A	NNP
cord-015021-pol2qm74	348	9	was	be	VBD
cord-015021-pol2qm74	348	10	specific	specific	JJ
cord-015021-pol2qm74	348	11	and	and	CC
cord-015021-pol2qm74	348	12	saturable	saturable	JJ
cord-015021-pol2qm74	348	13	with	with	IN
cord-015021-pol2qm74	348	14	apparent	apparent	JJ
cord-015021-pol2qm74	349	1	Kd	Kd	NNP
cord-015021-pol2qm74	349	2	'S	'S	NNP
cord-015021-pol2qm74	349	3	of	of	IN
cord-015021-pol2qm74	349	4	2.6	2.6	CD
cord-015021-pol2qm74	349	5	nM	nm	CD
cord-015021-pol2qm74	349	6	for	for	IN
cord-015021-pol2qm74	349	7	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	349	8	and	and	CC
cord-015021-pol2qm74	349	9	58	58	CD
cord-015021-pol2qm74	349	10	nM	nm	NN
cord-015021-pol2qm74	349	11	for	for	IN
cord-015021-pol2qm74	349	12	rLBP	rlbp	NN
cord-015021-pol2qm74	349	13	.	.	.
cord-015021-pol2qm74	350	1	In	in	IN
cord-015021-pol2qm74	350	2	a	a	DT
cord-015021-pol2qm74	350	3	competition	competition	NN
cord-015021-pol2qm74	350	4	assay	assay	NN
cord-015021-pol2qm74	350	5	format	format	NN
cord-015021-pol2qm74	350	6	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	350	7	was	be	VBD
cord-015021-pol2qm74	350	8	approximately	approximately	RB
cord-015021-pol2qm74	350	9	75-fold	75-fold	CD
cord-015021-pol2qm74	350	10	more	more	RBR
cord-015021-pol2qm74	350	11	potent	potent	JJ
cord-015021-pol2qm74	350	12	than	than	IN
cord-015021-pol2qm74	350	13	rLBP	rlbp	JJ
cord-015021-pol2qm74	350	14	in	in	IN
cord-015021-pol2qm74	350	15	inhibiting	inhibit	VBG
cord-015021-pol2qm74	350	16	the	the	DT
cord-015021-pol2qm74	350	17	binding	binding	NN
cord-015021-pol2qm74	350	18	of	of	IN
cord-015021-pol2qm74	350	19	nSI	nSI	NNP
cord-015021-pol2qm74	350	20	-	-	HYPH
cord-015021-pol2qm74	350	21	rLBP	rlbp	NN
cord-015021-pol2qm74	350	22	to	to	IN
cord-015021-pol2qm74	350	23	lipid	lipid	NN
cord-015021-pol2qm74	350	24	A.	a.	NN
cord-015021-pol2qm74	351	1	These	these	DT
cord-015021-pol2qm74	351	2	results	result	NNS
cord-015021-pol2qm74	351	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	351	4	that	that	IN
cord-015021-pol2qm74	351	5	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	351	6	has	have	VBZ
cord-015021-pol2qm74	351	7	a	a	DT
cord-015021-pol2qm74	351	8	significantly	significantly	RB
cord-015021-pol2qm74	351	9	higher	high	JJR
cord-015021-pol2qm74	351	10	affinity	affinity	NN
cord-015021-pol2qm74	351	11	for	for	IN
cord-015021-pol2qm74	351	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	351	13	than	than	IN
cord-015021-pol2qm74	351	14	does	do	VBZ
cord-015021-pol2qm74	351	15	rLBP	rlbp	NN
cord-015021-pol2qm74	351	16	and	and	CC
cord-015021-pol2qm74	351	17	may	may	MD
cord-015021-pol2qm74	351	18	explain	explain	VB
cord-015021-pol2qm74	351	19	the	the	DT
cord-015021-pol2qm74	351	20	potent	potent	JJ
cord-015021-pol2qm74	351	21	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	351	22	activity	activity	NN
cord-015021-pol2qm74	351	23	of	of	IN
cord-015021-pol2qm74	351	24	low	low	JJ
cord-015021-pol2qm74	351	25	concentrations	concentration	NNS
cord-015021-pol2qm74	351	26	of	of	IN
cord-015021-pol2qm74	351	27	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	351	28	in	in	IN
cord-015021-pol2qm74	351	29	a	a	DT
cord-015021-pol2qm74	351	30	variety	variety	NN
cord-015021-pol2qm74	351	31	of	of	IN
cord-015021-pol2qm74	351	32	in	in	FW
cord-015021-pol2qm74	351	33	vitro	vitro	FW
cord-015021-pol2qm74	351	34	functional	functional	JJ
cord-015021-pol2qm74	351	35	assays	assay	NNS
cord-015021-pol2qm74	351	36	for	for	IN
cord-015021-pol2qm74	351	37	LPS	LPS	NNP
cord-015021-pol2qm74	351	38	activation	activation	NN
cord-015021-pol2qm74	351	39	of	of	IN
cord-015021-pol2qm74	351	40	cells	cell	NNS
cord-015021-pol2qm74	351	41	despite	despite	IN
cord-015021-pol2qm74	351	42	the	the	DT
cord-015021-pol2qm74	351	43	presence	presence	NN
cord-015021-pol2qm74	351	44	of	of	IN
cord-015021-pol2qm74	351	45	high	high	JJ
cord-015021-pol2qm74	351	46	LBP	LBP	NNP
cord-015021-pol2qm74	351	47	levels	level	NNS
cord-015021-pol2qm74	351	48	.	.	.
cord-015021-pol2qm74	352	1	For	for	IN
cord-015021-pol2qm74	352	2	example	example	NN
cord-015021-pol2qm74	352	3	,	,	,
cord-015021-pol2qm74	352	4	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	352	5	at	at	IN
cord-015021-pol2qm74	352	6	0.2	0.2	CD
cord-015021-pol2qm74	353	1	~tg	~tg	NNP
cord-015021-pol2qm74	353	2	/	/	SYM
cord-015021-pol2qm74	353	3	mi	mi	NNP
cord-015021-pol2qm74	353	4	was	be	VBD
cord-015021-pol2qm74	353	5	able	able	JJ
cord-015021-pol2qm74	353	6	to	to	TO
cord-015021-pol2qm74	353	7	totally	totally	RB
cord-015021-pol2qm74	353	8	inhibit	inhibit	VB
cord-015021-pol2qm74	353	9	LPS	LPS	NNP
cord-015021-pol2qm74	353	10	-	-	HYPH
cord-015021-pol2qm74	353	11	induced	induce	VBN
cord-015021-pol2qm74	353	12	TNF	TNF	NNP
cord-015021-pol2qm74	353	13	release	release	NN
cord-015021-pol2qm74	353	14	from	from	IN
cord-015021-pol2qm74	353	15	monocytes	monocyte	NNS
cord-015021-pol2qm74	353	16	despite	despite	IN
cord-015021-pol2qm74	353	17	a	a	DT
cord-015021-pol2qm74	353	18	100-fold	100-fold	CD
cord-015021-pol2qm74	353	19	weight	weight	NN
cord-015021-pol2qm74	353	20	excess	excess	NN
cord-015021-pol2qm74	353	21	of	of	IN
cord-015021-pol2qm74	353	22	rLBP	rlbp	NN
cord-015021-pol2qm74	353	23	over	over	IN
cord-015021-pol2qm74	353	24	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	353	25	.	.	.
cord-015021-pol2qm74	354	1	and	and	CC
cord-015021-pol2qm74	354	2	for	for	IN
cord-015021-pol2qm74	354	3	heparin	heparin	NN
cord-015021-pol2qm74	354	4	binding	binding	NN
cord-015021-pol2qm74	354	5	.	.	.
cord-015021-pol2qm74	355	1	Three	three	CD
cord-015021-pol2qm74	355	2	separate	separate	JJ
cord-015021-pol2qm74	355	3	domains	domain	NNS
cord-015021-pol2qm74	355	4	which	which	WDT
cord-015021-pol2qm74	355	5	inhibit	inhibit	VBP
cord-015021-pol2qm74	355	6	the	the	DT
cord-015021-pol2qm74	355	7	LAL	LAL	NNP
cord-015021-pol2qm74	355	8	reaction	reaction	NN
cord-015021-pol2qm74	355	9	to	to	IN
cord-015021-pol2qm74	355	10	LPS	LPS	NNP
cord-015021-pol2qm74	355	11	and	and	CC
cord-015021-pol2qm74	355	12	bind	bind	VB
cord-015021-pol2qm74	355	13	to	to	IN
cord-015021-pol2qm74	355	14	heparin	heparin	NN
cord-015021-pol2qm74	355	15	were	be	VBD
cord-015021-pol2qm74	355	16	identified	identify	VBN
cord-015021-pol2qm74	355	17	in	in	IN
cord-015021-pol2qm74	355	18	amino	amino	JJ
cord-015021-pol2qm74	355	19	acid	acid	NN
cord-015021-pol2qm74	355	20	regions	region	NNS
cord-015021-pol2qm74	355	21	17	17	CD
cord-015021-pol2qm74	355	22	-	-	SYM
cord-015021-pol2qm74	355	23	45	45	CD
cord-015021-pol2qm74	355	24	,	,	,
cord-015021-pol2qm74	355	25	65	65	CD
cord-015021-pol2qm74	355	26	-	-	SYM
cord-015021-pol2qm74	355	27	99	99	CD
cord-015021-pol2qm74	355	28	and	and	CC
cord-015021-pol2qm74	355	29	142	142	CD
cord-015021-pol2qm74	355	30	-	-	SYM
cord-015021-pol2qm74	355	31	169	169	CD
cord-015021-pol2qm74	355	32	.	.	.
cord-015021-pol2qm74	356	1	A	a	DT
cord-015021-pol2qm74	356	2	single	single	JJ
cord-015021-pol2qm74	356	3	synthetic	synthetic	JJ
cord-015021-pol2qm74	356	4	peptide	peptide	NN
cord-015021-pol2qm74	356	5	(	(	-LRB-
cord-015021-pol2qm74	356	6	85	85	CD
cord-015021-pol2qm74	356	7	-	-	SYM
cord-015021-pol2qm74	356	8	99	99	CD
cord-015021-pol2qm74	356	9	)	)	-RRB-
cord-015021-pol2qm74	356	10	was	be	VBD
cord-015021-pol2qm74	356	11	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	356	12	.	.	.
cord-015021-pol2qm74	357	1	These	these	DT
cord-015021-pol2qm74	357	2	results	result	NNS
cord-015021-pol2qm74	357	3	suggest	suggest	VBP
cord-015021-pol2qm74	357	4	that	that	IN
cord-015021-pol2qm74	357	5	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	357	6	contains	contain	VBZ
cord-015021-pol2qm74	357	7	three	three	CD
cord-015021-pol2qm74	357	8	separate	separate	JJ
cord-015021-pol2qm74	357	9	functional	functional	JJ
cord-015021-pol2qm74	357	10	domains	domain	NNS
cord-015021-pol2qm74	357	11	which	which	WDT
cord-015021-pol2qm74	357	12	may	may	MD
cord-015021-pol2qm74	357	13	contribute	contribute	VB
cord-015021-pol2qm74	357	14	to	to	IN
cord-015021-pol2qm74	357	15	its	-PRON-	PRP$
cord-015021-pol2qm74	357	16	high	high	JJ
cord-015021-pol2qm74	357	17	affmity	affmity	NN
cord-015021-pol2qm74	357	18	interaction	interaction	NN
cord-015021-pol2qm74	357	19	with	with	IN
cord-015021-pol2qm74	357	20	Gram	gram	NN
cord-015021-pol2qm74	357	21	-	-	HYPH
cord-015021-pol2qm74	357	22	negative	negative	JJ
cord-015021-pol2qm74	357	23	bacteria	bacteria	NNS
cord-015021-pol2qm74	357	24	and	and	CC
cord-015021-pol2qm74	357	25	heparin	heparin	NN
cord-015021-pol2qm74	357	26	.	.	.
cord-015021-pol2qm74	358	1	The	the	DT
cord-015021-pol2qm74	358	2	individual	individual	JJ
cord-015021-pol2qm74	358	3	activity	activity	NN
cord-015021-pol2qm74	358	4	of	of	IN
cord-015021-pol2qm74	358	5	each	each	DT
cord-015021-pol2qm74	358	6	domain	domain	NN
cord-015021-pol2qm74	358	7	and	and	CC
cord-015021-pol2qm74	358	8	the	the	DT
cord-015021-pol2qm74	358	9	cooperative	cooperative	JJ
cord-015021-pol2qm74	358	10	interaction	interaction	NN
cord-015021-pol2qm74	358	11	among	among	IN
cord-015021-pol2qm74	358	12	domains	domain	NNS
cord-015021-pol2qm74	358	13	provide	provide	VBP
cord-015021-pol2qm74	358	14	the	the	DT
cord-015021-pol2qm74	358	15	basis	basis	NN
cord-015021-pol2qm74	358	16	for	for	IN
cord-015021-pol2qm74	358	17	developing	develop	VBG
cord-015021-pol2qm74	358	18	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	358	19	analogues	analogue	NNS
cord-015021-pol2qm74	358	20	with	with	IN
cord-015021-pol2qm74	358	21	increased	increase	VBN
cord-015021-pol2qm74	358	22	biologic	biologic	JJ
cord-015021-pol2qm74	358	23	efficacy	efficacy	NN
cord-015021-pol2qm74	358	24	.	.	.
cord-015021-pol2qm74	359	1	A	a	DT
cord-015021-pol2qm74	359	2	considerable	considerable	JJ
cord-015021-pol2qm74	359	3	body	body	NN
cord-015021-pol2qm74	359	4	of	of	IN
cord-015021-pol2qm74	359	5	experimental	experimental	JJ
cord-015021-pol2qm74	359	6	data	datum	NNS
cord-015021-pol2qm74	359	7	has	have	VBZ
cord-015021-pol2qm74	359	8	accumulated	accumulate	VBN
cord-015021-pol2qm74	359	9	implicating	implicate	VBG
cord-015021-pol2qm74	359	10	tumour	tumour	NN
cord-015021-pol2qm74	359	11	necrosis	necrosis	NN
cord-015021-pol2qm74	359	12	factor	factor	NN
cord-015021-pol2qm74	359	13	(	(	-LRB-
cord-015021-pol2qm74	359	14	TNF	TNF	NNP
cord-015021-pol2qm74	359	15	)	)	-RRB-
cord-015021-pol2qm74	359	16	as	as	IN
cord-015021-pol2qm74	359	17	a	a	DT
cord-015021-pol2qm74	359	18	principal	principal	JJ
cord-015021-pol2qm74	359	19	mediator	mediator	NN
cord-015021-pol2qm74	359	20	of	of	IN
cord-015021-pol2qm74	359	21	the	the	DT
cord-015021-pol2qm74	359	22	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	359	23	features	feature	NNS
cord-015021-pol2qm74	359	24	of	of	IN
cord-015021-pol2qm74	359	25	septic	septic	JJ
cord-015021-pol2qm74	359	26	shock	shock	NN
cord-015021-pol2qm74	359	27	.	.	.
cord-015021-pol2qm74	360	1	These	these	DT
cord-015021-pol2qm74	360	2	data	datum	NNS
cord-015021-pol2qm74	360	3	prompted	prompt	VBD
cord-015021-pol2qm74	360	4	the	the	DT
cord-015021-pol2qm74	360	5	development	development	NN
cord-015021-pol2qm74	360	6	of	of	IN
cord-015021-pol2qm74	360	7	clinical	clinical	JJ
cord-015021-pol2qm74	360	8	strategies	strategy	NNS
cord-015021-pol2qm74	360	9	designed	design	VBN
cord-015021-pol2qm74	360	10	to	to	TO
cord-015021-pol2qm74	360	11	limit	limit	VB
cord-015021-pol2qm74	360	12	excess	excess	JJ
cord-015021-pol2qm74	360	13	(	(	-LRB-
cord-015021-pol2qm74	360	14	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	360	15	)	)	-RRB-
cord-015021-pol2qm74	360	16	TNF	tnf	NN
cord-015021-pol2qm74	360	17	production	production	NN
cord-015021-pol2qm74	360	18	.	.	.
cord-015021-pol2qm74	361	1	Monoclonoal	Monoclonoal	NNP
cord-015021-pol2qm74	361	2	antibodies	antibody	NNS
cord-015021-pol2qm74	361	3	(	(	-LRB-
cord-015021-pol2qm74	361	4	Mobs	mob	NNS
cord-015021-pol2qm74	361	5	)	)	-RRB-
cord-015021-pol2qm74	361	6	were	be	VBD
cord-015021-pol2qm74	361	7	developed	develop	VBN
cord-015021-pol2qm74	361	8	and	and	CC
cord-015021-pol2qm74	361	9	a	a	DT
cord-015021-pol2qm74	361	10	phase	phase	NN
cord-015021-pol2qm74	361	11	II	ii	CD
cord-015021-pol2qm74	362	1	dose	dose	JJ
cord-015021-pol2qm74	362	2	escalation	escalation	NN
cord-015021-pol2qm74	362	3	trial	trial	NN
cord-015021-pol2qm74	362	4	in	in	IN
cord-015021-pol2qm74	362	5	80	80	CD
cord-015021-pol2qm74	362	6	patients	patient	NNS
cord-015021-pol2qm74	362	7	confirmed	confirm	VBD
cord-015021-pol2qm74	362	8	that	that	IN
cord-015021-pol2qm74	362	9	the	the	DT
cord-015021-pol2qm74	362	10	Mab	Mab	NNP
cord-015021-pol2qm74	362	11	was	be	VBD
cord-015021-pol2qm74	362	12	safe	safe	JJ
cord-015021-pol2qm74	362	13	,	,	,
cord-015021-pol2qm74	362	14	and	and	CC
cord-015021-pol2qm74	362	15	suggested	suggest	VBD
cord-015021-pol2qm74	362	16	that	that	IN
cord-015021-pol2qm74	362	17	it	-PRON-	PRP
cord-015021-pol2qm74	362	18	was	be	VBD
cord-015021-pol2qm74	362	19	having	have	VBG
cord-015021-pol2qm74	362	20	a	a	DT
cord-015021-pol2qm74	362	21	beneficial	beneficial	JJ
cord-015021-pol2qm74	362	22	effect	effect	NN
cord-015021-pol2qm74	362	23	on	on	IN
cord-015021-pol2qm74	362	24	certain	certain	JJ
cord-015021-pol2qm74	362	25	parameters	parameter	NNS
cord-015021-pol2qm74	362	26	.	.	.
cord-015021-pol2qm74	363	1	Preliminary	preliminary	JJ
cord-015021-pol2qm74	363	2	results	result	NNS
cord-015021-pol2qm74	363	3	of	of	IN
cord-015021-pol2qm74	363	4	a	a	DT
cord-015021-pol2qm74	363	5	large	large	JJ
cord-015021-pol2qm74	363	6	phase	phase	NN
cord-015021-pol2qm74	363	7	III	iii	CD
cord-015021-pol2qm74	363	8	study	study	NN
cord-015021-pol2qm74	363	9	indicated	indicate	VBD
cord-015021-pol2qm74	363	10	that	that	IN
cord-015021-pol2qm74	363	11	(	(	-LRB-
cord-015021-pol2qm74	363	12	a	a	LS
cord-015021-pol2qm74	363	13	)	)	-RRB-
cord-015021-pol2qm74	363	14	the	the	DT
cord-015021-pol2qm74	363	15	Mob	Mob	NNP
cord-015021-pol2qm74	363	16	was	be	VBD
cord-015021-pol2qm74	363	17	safe	safe	JJ
cord-015021-pol2qm74	363	18	;	;	:
cord-015021-pol2qm74	363	19	(	(	-LRB-
cord-015021-pol2qm74	363	20	b	b	NN
cord-015021-pol2qm74	363	21	)	)	-RRB-
cord-015021-pol2qm74	363	22	that	that	IN
cord-015021-pol2qm74	363	23	it	-PRON-	PRP
cord-015021-pol2qm74	363	24	was	be	VBD
cord-015021-pol2qm74	363	25	of	of	IN
cord-015021-pol2qm74	363	26	no	no	DT
cord-015021-pol2qm74	363	27	discernible	discernible	JJ
cord-015021-pol2qm74	363	28	benefit	benefit	NN
cord-015021-pol2qm74	363	29	in	in	IN
cord-015021-pol2qm74	363	30	non	non	JJ
cord-015021-pol2qm74	363	31	-	-	JJ
cord-015021-pol2qm74	363	32	shocked	shocked	JJ
cord-015021-pol2qm74	363	33	patients	patient	NNS
cord-015021-pol2qm74	363	34	;	;	,
cord-015021-pol2qm74	363	35	(	(	-LRB-
cord-015021-pol2qm74	363	36	c	c	NN
cord-015021-pol2qm74	363	37	)	)	-RRB-
cord-015021-pol2qm74	363	38	that	that	IN
cord-015021-pol2qm74	363	39	it	-PRON-	PRP
cord-015021-pol2qm74	363	40	reduced	reduce	VBD
cord-015021-pol2qm74	363	41	mortality	mortality	NN
cord-015021-pol2qm74	363	42	in	in	IN
cord-015021-pol2qm74	363	43	shocked	shocked	JJ
cord-015021-pol2qm74	363	44	patients	patient	NNS
cord-015021-pol2qm74	363	45	,	,	,
cord-015021-pol2qm74	363	46	especially	especially	RB
cord-015021-pol2qm74	363	47	during	during	IN
cord-015021-pol2qm74	363	48	the	the	DT
cord-015021-pol2qm74	363	49	first	first	JJ
cord-015021-pol2qm74	363	50	3	3	CD
cord-015021-pol2qm74	363	51	days	day	NNS
cord-015021-pol2qm74	363	52	.	.	.
cord-015021-pol2qm74	364	1	An	an	DT
cord-015021-pol2qm74	364	2	alternative	alternative	JJ
cord-015021-pol2qm74	364	3	strategy	strategy	NN
cord-015021-pol2qm74	364	4	was	be	VBD
cord-015021-pol2qm74	364	5	to	to	TO
cord-015021-pol2qm74	364	6	take	take	VB
cord-015021-pol2qm74	364	7	advantage	advantage	NN
cord-015021-pol2qm74	364	8	of	of	IN
cord-015021-pol2qm74	364	9	the	the	DT
cord-015021-pol2qm74	364	10	high	high	JJ
cord-015021-pol2qm74	364	11	binding	bind	VBG
cord-015021-pol2qm74	364	12	affinity	affinity	NN
cord-015021-pol2qm74	364	13	of	of	IN
cord-015021-pol2qm74	364	14	soluble	soluble	JJ
cord-015021-pol2qm74	364	15	receptors	receptor	NNS
cord-015021-pol2qm74	364	16	for	for	IN
cord-015021-pol2qm74	364	17	TNF	TNF	NNP
cord-015021-pol2qm74	364	18	(	(	-LRB-
cord-015021-pol2qm74	364	19	sTNFR	sTNFR	NNP
cord-015021-pol2qm74	364	20	)	)	-RRB-
cord-015021-pol2qm74	364	21	.	.	.
cord-015021-pol2qm74	365	1	sTNFR	sTNFR	NNP
cord-015021-pol2qm74	365	2	-	-	HYPH
cord-015021-pol2qm74	365	3	IgGFc	iggfc	NN
cord-015021-pol2qm74	365	4	constructs	construct	NNS
cord-015021-pol2qm74	365	5	were	be	VBD
cord-015021-pol2qm74	365	6	made	make	VBN
cord-015021-pol2qm74	365	7	for	for	IN
cord-015021-pol2qm74	365	8	both	both	CC
cord-015021-pol2qm74	365	9	the	the	DT
cord-015021-pol2qm74	365	10	p55	p55	NN
cord-015021-pol2qm74	365	11	and	and	CC
cord-015021-pol2qm74	365	12	p75	p75	NN
cord-015021-pol2qm74	365	13	receptors	receptor	NNS
cord-015021-pol2qm74	365	14	.	.	.
cord-015021-pol2qm74	366	1	Both	both	DT
cord-015021-pol2qm74	366	2	were	be	VBD
cord-015021-pol2qm74	366	3	effective	effective	JJ
cord-015021-pol2qm74	366	4	in	in	IN
cord-015021-pol2qm74	366	5	animal	animal	NN
cord-015021-pol2qm74	366	6	models	model	NNS
cord-015021-pol2qm74	366	7	of	of	IN
cord-015021-pol2qm74	366	8	LPS	LPS	NNP
cord-015021-pol2qm74	366	9	challenge	challenge	NN
cord-015021-pol2qm74	366	10	,	,	,
cord-015021-pol2qm74	366	11	but	but	CC
cord-015021-pol2qm74	366	12	when	when	WRB
cord-015021-pol2qm74	366	13	a	a	DT
cord-015021-pol2qm74	366	14	clinical	clinical	JJ
cord-015021-pol2qm74	366	15	trial	trial	NN
cord-015021-pol2qm74	366	16	was	be	VBD
cord-015021-pol2qm74	366	17	done	do	VBN
cord-015021-pol2qm74	366	18	with	with	IN
cord-015021-pol2qm74	366	19	the	the	DT
cord-015021-pol2qm74	366	20	p75	p75	NNP
cord-015021-pol2qm74	366	21	sTNFR	stnfr	NN
cord-015021-pol2qm74	366	22	-	-	HYPH
cord-015021-pol2qm74	366	23	Fc	Fc	NNP
cord-015021-pol2qm74	367	1	there	there	EX
cord-015021-pol2qm74	367	2	was	be	VBD
cord-015021-pol2qm74	367	3	unexpected	unexpected	JJ
cord-015021-pol2qm74	367	4	mortality	mortality	NN
cord-015021-pol2qm74	367	5	in	in	IN
cord-015021-pol2qm74	367	6	the	the	DT
cord-015021-pol2qm74	367	7	treated	treated	JJ
cord-015021-pol2qm74	367	8	arm	arm	NN
cord-015021-pol2qm74	367	9	.	.	.
cord-015021-pol2qm74	368	1	Using	use	VBG
cord-015021-pol2qm74	368	2	an	an	DT
cord-015021-pol2qm74	368	3	animal	animal	NN
cord-015021-pol2qm74	368	4	model	model	NN
cord-015021-pol2qm74	368	5	of	of	IN
cord-015021-pol2qm74	368	6	live	live	JJ
cord-015021-pol2qm74	368	7	E.coli	e.coli	NN
cord-015021-pol2qm74	368	8	sepsis	sepsis	NN
cord-015021-pol2qm74	368	9	,	,	,
cord-015021-pol2qm74	368	10	we	-PRON-	PRP
cord-015021-pol2qm74	368	11	have	have	VBP
cord-015021-pol2qm74	368	12	shown	show	VBN
cord-015021-pol2qm74	368	13	that	that	IN
cord-015021-pol2qm74	368	14	this	this	DT
cord-015021-pol2qm74	368	15	may	may	MD
cord-015021-pol2qm74	368	16	have	have	VB
cord-015021-pol2qm74	368	17	been	be	VBN
cord-015021-pol2qm74	368	18	due	due	JJ
cord-015021-pol2qm74	368	19	to	to	IN
cord-015021-pol2qm74	368	20	the	the	DT
cord-015021-pol2qm74	368	21	release	release	NN
cord-015021-pol2qm74	368	22	of	of	IN
cord-015021-pol2qm74	368	23	bound	bind	VBN
cord-015021-pol2qm74	368	24	TNF	TNF	NNP
cord-015021-pol2qm74	368	25	from	from	IN
cord-015021-pol2qm74	368	26	the	the	DT
cord-015021-pol2qm74	368	27	construct	construct	NN
cord-015021-pol2qm74	368	28	.	.	.
cord-015021-pol2qm74	369	1	Plasma	plasma	NN
cord-015021-pol2qm74	369	2	enhances	enhance	VBZ
cord-015021-pol2qm74	369	3	while	while	IN
cord-015021-pol2qm74	369	4	BPI	BPI	NNP
cord-015021-pol2qm74	369	5	inhibits	inhibit	VBZ
cord-015021-pol2qm74	369	6	LPS	LPS	NNP
cord-015021-pol2qm74	369	7	-	-	HYPH
cord-015021-pol2qm74	369	8	induced	induce	VBN
cord-015021-pol2qm74	369	9	cytokine	cytokine	NN
cord-015021-pol2qm74	369	10	production	production	NN
cord-015021-pol2qm74	369	11	from	from	IN
cord-015021-pol2qm74	369	12	peripheral	peripheral	JJ
cord-015021-pol2qm74	369	13	blood	blood	NN
cord-015021-pol2qm74	369	14	mononuclear	mononuclear	NN
cord-015021-pol2qm74	369	15	cells	cell	NNS
cord-015021-pol2qm74	369	16	(	(	-LRB-
cord-015021-pol2qm74	369	17	PBMC	PBMC	NNP
cord-015021-pol2qm74	369	18	)	)	-RRB-
cord-015021-pol2qm74	369	19	.	.	.
cord-015021-pol2qm74	370	1	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	370	2	species	specie	NNS
cord-015021-pol2qm74	370	3	produce	produce	VBP
cord-015021-pol2qm74	370	4	cytokine	cytokine	NN
cord-015021-pol2qm74	370	5	-	-	HYPH
cord-015021-pol2qm74	370	6	inducing	induce	VBG
cord-015021-pol2qm74	370	7	substances	substance	NNS
cord-015021-pol2qm74	370	8	which	which	WDT
cord-015021-pol2qm74	370	9	are	be	VBP
cord-015021-pol2qm74	370	10	different	different	JJ
cord-015021-pol2qm74	370	11	from	from	IN
cord-015021-pol2qm74	370	12	LPS	LPS	NNP
cord-015021-pol2qm74	370	13	as	as	IN
cord-015021-pol2qm74	370	14	indicated	indicate	VBN
cord-015021-pol2qm74	370	15	by	by	IN
cord-015021-pol2qm74	370	16	the	the	DT
cord-015021-pol2qm74	370	17	fact	fact	NN
cord-015021-pol2qm74	370	18	that	that	IN
cord-015021-pol2qm74	370	19	polymyxin	polymyxin	NN
cord-015021-pol2qm74	370	20	B	B	NNP
cord-015021-pol2qm74	370	21	blocks	block	VBZ
cord-015021-pol2qm74	370	22	only	only	RB
cord-015021-pol2qm74	370	23	40	40	CD
cord-015021-pol2qm74	370	24	%	%	NN
cord-015021-pol2qm74	370	25	of	of	IN
cord-015021-pol2qm74	370	26	the	the	DT
cord-015021-pol2qm74	370	27	cytokine	cytokine	NN
cord-015021-pol2qm74	370	28	-	-	HYPH
cord-015021-pol2qm74	370	29	inducing	induce	VBG
cord-015021-pol2qm74	370	30	activity	activity	NN
cord-015021-pol2qm74	370	31	of	of	IN
cord-015021-pol2qm74	370	32	these	these	DT
cord-015021-pol2qm74	370	33	pyrogens	pyrogen	NNS
cord-015021-pol2qm74	370	34	.	.	.
cord-015021-pol2qm74	371	1	We	-PRON-	PRP
cord-015021-pol2qm74	371	2	now	now	RB
cord-015021-pol2qm74	371	3	tested	test	VBD
cord-015021-pol2qm74	371	4	the	the	DT
cord-015021-pol2qm74	371	5	effect	effect	NN
cord-015021-pol2qm74	371	6	of	of	IN
cord-015021-pol2qm74	371	7	plasma	plasma	NN
cord-015021-pol2qm74	371	8	and	and	CC
cord-015021-pol2qm74	371	9	BPI	BPI	NNP
cord-015021-pol2qm74	371	10	on	on	IN
cord-015021-pol2qm74	371	11	the	the	DT
cord-015021-pol2qm74	371	12	IL-1[3-inducing	il-1[3-inducing	NN
cord-015021-pol2qm74	371	13	activity	activity	NN
cord-015021-pol2qm74	371	14	of	of	IN
cord-015021-pol2qm74	371	15	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	371	16	maltophilia	maltophilia	NNP
cord-015021-pol2qm74	371	17	-derived	-derived	SYM
cord-015021-pol2qm74	371	18	pyrogens	pyrogens	NNP
cord-015021-pol2qm74	371	19	(	(	-LRB-
cord-015021-pol2qm74	371	20	Pmp	Pmp	NNP
cord-015021-pol2qm74	371	21	)	)	-RRB-
cord-015021-pol2qm74	371	22	.	.	.
cord-015021-pol2qm74	372	1	Bacteria	Bacteria	NNS
cord-015021-pol2qm74	372	2	were	be	VBD
cord-015021-pol2qm74	372	3	cultured	culture	VBN
cord-015021-pol2qm74	372	4	to	to	IN
cord-015021-pol2qm74	372	5	the	the	DT
cord-015021-pol2qm74	372	6	log	log	NN
cord-015021-pol2qm74	372	7	phase	phase	NN
cord-015021-pol2qm74	372	8	and	and	CC
cord-015021-pol2qm74	372	9	filtered	filter	VBN
cord-015021-pol2qm74	372	10	(	(	-LRB-
cord-015021-pol2qm74	372	11	300kD	300kd	NN
cord-015021-pol2qm74	372	12	)	)	-RRB-
cord-015021-pol2qm74	372	13	to	to	TO
cord-015021-pol2qm74	372	14	obtain	obtain	VB
cord-015021-pol2qm74	372	15	Prop	Prop	NNP
cord-015021-pol2qm74	372	16	.	.	.
cord-015021-pol2qm74	373	1	Dilutions	dilution	NNS
cord-015021-pol2qm74	373	2	of	of	IN
cord-015021-pol2qm74	373	3	Pmp	Pmp	NNP
cord-015021-pol2qm74	373	4	or	or	CC
cord-015021-pol2qm74	373	5	LPS	LPS	NNP
cord-015021-pol2qm74	373	6	were	be	VBD
cord-015021-pol2qm74	373	7	added	add	VBN
cord-015021-pol2qm74	373	8	to	to	IN
cord-015021-pol2qm74	373	9	PBMC	PBMC	NNP
cord-015021-pol2qm74	373	10	alone	alone	RB
cord-015021-pol2qm74	373	11	or	or	CC
cord-015021-pol2qm74	373	12	to	to	IN
cord-015021-pol2qm74	373	13	PBMC	PBMC	NNP
cord-015021-pol2qm74	373	14	in	in	IN
cord-015021-pol2qm74	373	15	5	5	CD
cord-015021-pol2qm74	373	16	%	%	NN
cord-015021-pol2qm74	373	17	plasma	plasma	NN
cord-015021-pol2qm74	373	18	+	+	CC
cord-015021-pol2qm74	374	1	/-BPI	/-BPI	NNP
cord-015021-pol2qm74	374	2	(	(	-LRB-
cord-015021-pol2qm74	374	3	500	500	CD
cord-015021-pol2qm74	374	4	ng	ng	NN
cord-015021-pol2qm74	374	5	/	/	SYM
cord-015021-pol2qm74	374	6	ml	ml	NN
cord-015021-pol2qm74	374	7	)	)	-RRB-
cord-015021-pol2qm74	374	8	.	.	.
cord-015021-pol2qm74	375	1	PBMC	PBMC	NNS
cord-015021-pol2qm74	375	2	were	be	VBD
cord-015021-pol2qm74	375	3	incubated	incubate	VBN
cord-015021-pol2qm74	375	4	for	for	IN
cord-015021-pol2qm74	375	5	24	24	CD
cord-015021-pol2qm74	375	6	hours	hour	NNS
cord-015021-pol2qm74	375	7	at	at	IN
cord-015021-pol2qm74	375	8	37	37	CD
cord-015021-pol2qm74	375	9	°	°	NN
cord-015021-pol2qm74	375	10	C	c	NN
cord-015021-pol2qm74	375	11	and	and	CC
cord-015021-pol2qm74	375	12	total	total	JJ
cord-015021-pol2qm74	375	13	IL	IL	NNP
cord-015021-pol2qm74	375	14	-	-	HYPH
cord-015021-pol2qm74	375	15	I~	I~	NNP
cord-015021-pol2qm74	375	16	was	be	VBD
cord-015021-pol2qm74	375	17	measured	measure	VBN
cord-015021-pol2qm74	375	18	by	by	IN
cord-015021-pol2qm74	375	19	RIA	RIA	NNP
cord-015021-pol2qm74	375	20	.	.	.
cord-015021-pol2qm74	376	1	Results	result	NNS
cord-015021-pol2qm74	376	2	:	:	:
cord-015021-pol2qm74	377	1	IL	IL	NNP
cord-015021-pol2qm74	377	2	-	-	HYPH
cord-015021-pol2qm74	377	3	I[~	I[~	NNP
cord-015021-pol2qm74	377	4	in	in	IN
cord-015021-pol2qm74	377	5	ng	ng	NNP
cord-015021-pol2qm74	377	6	/	/	SYM
cord-015021-pol2qm74	377	7	ml	ml	NN
cord-015021-pol2qm74	378	1	(	(	-LRB-
cord-015021-pol2qm74	378	2	n=7	n=7	NNS
cord-015021-pol2qm74	378	3	,	,	,
cord-015021-pol2qm74	378	4	mear~+SEM	mear~+sem	UH
cord-015021-pol2qm74	378	5	,	,	,
cord-015021-pol2qm74	379	1	*	*	NFP
cord-015021-pol2qm74	379	2	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	379	3	vs	vs	IN
cord-015021-pol2qm74	379	4	control	control	NN
cord-015021-pol2qm74	379	5	)	)	-RRB-
cord-015021-pol2qm74	379	6	.	.	.
cord-015021-pol2qm74	379	7	0	0	NFP
cord-015021-pol2qm74	380	1	control	control	NNP
cord-015021-pol2qm74	380	2	0.1_+0	0.1_+0	CD
cord-015021-pol2qm74	380	3	+	+	CC
cord-015021-pol2qm74	380	4	BPI	BPI	NNP
cord-015021-pol2qm74	380	5	0.1	0.1	CD
cord-015021-pol2qm74	380	6	+	+	SYM
cord-015021-pol2qm74	380	7	0	0	CD
cord-015021-pol2qm74	380	8	5	5	CD
cord-015021-pol2qm74	380	9	%	%	NN
cord-015021-pol2qm74	380	10	plas	plas	NNP
cord-015021-pol2qm74	380	11	.	.	.
cord-015021-pol2qm74	381	1	0.2_+0	0.2_+0	NNP
cord-015021-pol2qm74	381	2	+	+	CC
cord-015021-pol2qm74	382	1	BPI	BPI	NNP
cord-015021-pol2qm74	382	2	0.2_+0	0.2_+0	NNP
cord-015021-pol2qm74	382	3	Pmp	Pmp	NNP
cord-015021-pol2qm74	382	4	(	(	-LRB-
cord-015021-pol2qm74	382	5	ng	ng	NNP
cord-015021-pol2qm74	382	6	/	/	SYM
cord-015021-pol2qm74	382	7	ml	ml	NN
cord-015021-pol2qm74	382	8	)	)	-RRB-
cord-015021-pol2qm74	382	9	LPS	LPS	NNP
cord-015021-pol2qm74	382	10	(	(	-LRB-
cord-015021-pol2qm74	382	11	ng	ng	NNP
cord-015021-pol2qm74	382	12	/	/	SYM
cord-015021-pol2qm74	382	13	ml	ml	NN
cord-015021-pol2qm74	382	14	)	)	-RRB-
cord-015021-pol2qm74	383	1	60	60	CD
cord-015021-pol2qm74	383	2	600	600	CD
cord-015021-pol2qm74	383	3	3000	3000	CD
cord-015021-pol2qm74	383	4	1	1	CD
cord-015021-pol2qm74	383	5	10	10	CD
cord-015021-pol2qm74	383	6	3.2_+1	3.2_+1	CD
cord-015021-pol2qm74	383	7	8.0_+1	8.0_+1	CD
cord-015021-pol2qm74	384	1	16.3_+3	16.3_+3	CD
cord-015021-pol2qm74	384	2	1.2_+	1.2_+	NN
cord-015021-pol2qm74	384	3	.	.	.
cord-015021-pol2qm74	385	1	2	2	LS
cord-015021-pol2qm74	386	1	5.2+.6	5.2+.6	CD
cord-015021-pol2qm74	386	2	0.2_+.1	0.2_+.1	CD
cord-015021-pol2qm74	387	1	3.3_+.9	3.3_+.9	CD
cord-015021-pol2qm74	387	2	"	"	``
cord-015021-pol2qm74	387	3	13_+3	13_+3	CD
cord-015021-pol2qm74	387	4	"	"	''
cord-015021-pol2qm74	387	5	0.1_+0	0.1_+0	NNP
cord-015021-pol2qm74	387	6	"	"	''
cord-015021-pol2qm74	387	7	0.1_+0	0.1_+0	CD
cord-015021-pol2qm74	387	8	"	"	''
cord-015021-pol2qm74	388	1	2.2_+	2.2_+	UH
cord-015021-pol2qm74	388	2	.	.	.
cord-015021-pol2qm74	389	1	5	5	CD
cord-015021-pol2qm74	389	2	5.7	5.7	CD
cord-015021-pol2qm74	389	3	+	+	SYM
cord-015021-pol2qm74	389	4	1	1	CD
cord-015021-pol2qm74	389	5	14_+2	14_+2	CD
cord-015021-pol2qm74	390	1	5_+.6	5_+.6	LS
cord-015021-pol2qm74	390	2	*	*	NFP
cord-015021-pol2qm74	390	3	14_+2	14_+2	CD
cord-015021-pol2qm74	390	4	"	"	``
cord-015021-pol2qm74	390	5	0.6	0.6	CD
cord-015021-pol2qm74	391	1	+	+	CC
cord-015021-pol2qm74	391	2	.	.	NN
cord-015021-pol2qm74	391	3	4	4	CD
cord-015021-pol2qm74	391	4	"	"	``
cord-015021-pol2qm74	391	5	5.3	5.3	CD
cord-015021-pol2qm74	391	6	+	+	SYM
cord-015021-pol2qm74	391	7	1	1	CD
cord-015021-pol2qm74	392	1	15-+2	15-+2	CD
cord-015021-pol2qm74	392	2	0.1-+0	0.1-+0	CD
cord-015021-pol2qm74	392	3	"	"	``
cord-015021-pol2qm74	392	4	0.5_+.3	0.5_+.3	NNP
cord-015021-pol2qm74	392	5	"	"	''
cord-015021-pol2qm74	392	6	CBA	CBA	NNP
cord-015021-pol2qm74	392	7	,	,	,
cord-015021-pol2qm74	392	8	C57BL/6	C57BL/6	NNP
cord-015021-pol2qm74	392	9	,	,	,
cord-015021-pol2qm74	392	10	BALB	BALB	NNP
cord-015021-pol2qm74	392	11	/	/	SYM
cord-015021-pol2qm74	392	12	C	C	NNP
cord-015021-pol2qm74	392	13	,	,	,
cord-015021-pol2qm74	392	14	AKR	AKR	NNP
cord-015021-pol2qm74	392	15	,	,	,
cord-015021-pol2qm74	392	16	DBA	DBA	NNP
cord-015021-pol2qm74	392	17	,	,	,
cord-015021-pol2qm74	392	18	Swiss	swiss	JJ
cord-015021-pol2qm74	392	19	mice	mouse	NNS
cord-015021-pol2qm74	392	20	,	,	,
cord-015021-pol2qm74	392	21	guinea	guinea	NN
cord-015021-pol2qm74	392	22	pigs	pig	NNS
cord-015021-pol2qm74	392	23	,	,	,
cord-015021-pol2qm74	392	24	rabbits	rabbit	NNS
cord-015021-pol2qm74	392	25	have	have	VBP
cord-015021-pol2qm74	392	26	been	be	VBN
cord-015021-pol2qm74	392	27	used	use	VBN
cord-015021-pol2qm74	392	28	in	in	IN
cord-015021-pol2qm74	392	29	research	research	NN
cord-015021-pol2qm74	392	30	work	work	NN
cord-015021-pol2qm74	392	31	.	.	.
cord-015021-pol2qm74	393	1	The	the	DT
cord-015021-pol2qm74	393	2	toxicity	toxicity	NN
cord-015021-pol2qm74	393	3	,	,	,
cord-015021-pol2qm74	393	4	immunogenicity	immunogenicity	NN
cord-015021-pol2qm74	393	5	,	,	,
cord-015021-pol2qm74	393	6	mitogenic	mitogenic	NNP
cord-015021-pol2qm74	393	7	and	and	CC
cord-015021-pol2qm74	393	8	immunomodulating	immunomodulating	JJ
cord-015021-pol2qm74	393	9	activity	activity	NN
cord-015021-pol2qm74	393	10	of	of	IN
cord-015021-pol2qm74	393	11	LPS	lp	NNS
cord-015021-pol2qm74	393	12	have	have	VBP
cord-015021-pol2qm74	393	13	been	be	VBN
cord-015021-pol2qm74	393	14	studied	study	VBN
cord-015021-pol2qm74	393	15	.	.	.
cord-015021-pol2qm74	394	1	The	the	DT
cord-015021-pol2qm74	394	2	possibility	possibility	NN
cord-015021-pol2qm74	394	3	of	of	IN
cord-015021-pol2qm74	394	4	reduction	reduction	NN
cord-015021-pol2qm74	394	5	of	of	IN
cord-015021-pol2qm74	394	6	the	the	DT
cord-015021-pol2qm74	394	7	toxic	toxic	JJ
cord-015021-pol2qm74	394	8	activity	activity	NN
cord-015021-pol2qm74	394	9	of	of	IN
cord-015021-pol2qm74	394	10	LPS	LPS	NNP
cord-015021-pol2qm74	394	11	on	on	IN
cord-015021-pol2qm74	394	12	macroorganism	macroorganism	NNP
cord-015021-pol2qm74	394	13	by	by	IN
cord-015021-pol2qm74	394	14	bioglycansimmunomodulators	bioglycansimmunomodulator	NNS
cord-015021-pol2qm74	394	15	obtained	obtain	VBN
cord-015021-pol2qm74	394	16	from	from	IN
cord-015021-pol2qm74	394	17	sea	sea	NN
cord-015021-pol2qm74	394	18	invertebrates	invertebrate	NNS
cord-015021-pol2qm74	394	19	anymals	anymal	NNS
cord-015021-pol2qm74	394	20	(	(	-LRB-
cord-015021-pol2qm74	394	21	Crenomytilus	Crenomytilus	NNP
cord-015021-pol2qm74	394	22	grayanus	grayanus	NNP
cord-015021-pol2qm74	394	23	,	,	,
cord-015021-pol2qm74	394	24	Stromhus	Stromhus	NNP
cord-015021-pol2qm74	394	25	gigas	gigas	NNP
cord-015021-pol2qm74	394	26	)	)	-RRB-
cord-015021-pol2qm74	394	27	have	have	VBP
cord-015021-pol2qm74	394	28	been	be	VBN
cord-015021-pol2qm74	394	29	investigated	investigate	VBN
cord-015021-pol2qm74	394	30	too	too	RB
cord-015021-pol2qm74	394	31	.	.	.
cord-015021-pol2qm74	395	1	LPS	LPS	NNP
cord-015021-pol2qm74	395	2	has	have	VBZ
cord-015021-pol2qm74	395	3	been	be	VBN
cord-015021-pol2qm74	395	4	shown	show	VBN
cord-015021-pol2qm74	395	5	to	to	TO
cord-015021-pol2qm74	395	6	induce	induce	VB
cord-015021-pol2qm74	395	7	specific	specific	JJ
cord-015021-pol2qm74	395	8	antibody	antibody	NN
cord-015021-pol2qm74	395	9	response	response	NN
cord-015021-pol2qm74	395	10	of	of	IN
cord-015021-pol2qm74	395	11	laboratory	laboratory	NN
cord-015021-pol2qm74	395	12	animals	animal	NNS
cord-015021-pol2qm74	395	13	.	.	.
cord-015021-pol2qm74	396	1	CBA	CBA	NNP
cord-015021-pol2qm74	396	2	mice	mouse	NNS
cord-015021-pol2qm74	396	3	are	be	VBP
cord-015021-pol2qm74	396	4	high	high	JJ
cord-015021-pol2qm74	396	5	responsive	responsive	JJ
cord-015021-pol2qm74	396	6	to	to	IN
cord-015021-pol2qm74	396	7	LPS	LPS	NNP
cord-015021-pol2qm74	396	8	.	.	.
cord-015021-pol2qm74	397	1	LPS	LPS	NNP
cord-015021-pol2qm74	397	2	stimulates	stimulate	VBZ
cord-015021-pol2qm74	397	3	humoral	humoral	JJ
cord-015021-pol2qm74	397	4	immune	immune	JJ
cord-015021-pol2qm74	397	5	response	response	NN
cord-015021-pol2qm74	397	6	of	of	IN
cord-015021-pol2qm74	397	7	mice	mouse	NNS
cord-015021-pol2qm74	397	8	to	to	IN
cord-015021-pol2qm74	397	9	Tdependent	Tdependent	NNP
cord-015021-pol2qm74	397	10	and	and	CC
cord-015021-pol2qm74	397	11	T	T	NNP
cord-015021-pol2qm74	397	12	-	-	HYPH
cord-015021-pol2qm74	397	13	independent	independent	JJ
cord-015021-pol2qm74	397	14	antigens	antigen	NNS
cord-015021-pol2qm74	397	15	and	and	CC
cord-015021-pol2qm74	397	16	suppresses	suppress	VBZ
cord-015021-pol2qm74	397	17	intensity	intensity	NN
cord-015021-pol2qm74	397	18	of	of	IN
cord-015021-pol2qm74	397	19	the	the	DT
cord-015021-pol2qm74	397	20	delayed	delay	VBN
cord-015021-pol2qm74	397	21	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	397	22	.	.	.
cord-015021-pol2qm74	398	1	The	the	DT
cord-015021-pol2qm74	398	2	small	small	JJ
cord-015021-pol2qm74	398	3	doses	dose	NNS
cord-015021-pol2qm74	398	4	of	of	IN
cord-015021-pol2qm74	398	5	LPS	lp	NNS
cord-015021-pol2qm74	398	6	stimulate	stimulate	VBP
cord-015021-pol2qm74	398	7	functional	functional	JJ
cord-015021-pol2qm74	398	8	activity	activity	NN
cord-015021-pol2qm74	398	9	of	of	IN
cord-015021-pol2qm74	398	10	macrophages	macrophage	NNS
cord-015021-pol2qm74	398	11	,	,	,
cord-015021-pol2qm74	398	12	the	the	DT
cord-015021-pol2qm74	398	13	large	large	JJ
cord-015021-pol2qm74	398	14	doses	dose	NNS
cord-015021-pol2qm74	398	15	of	of	IN
cord-015021-pol2qm74	398	16	LPS	LPS	NNP
cord-015021-pol2qm74	398	17	-decrease	-decrease	:
cord-015021-pol2qm74	398	18	one	one	CD
cord-015021-pol2qm74	398	19	and	and	CC
cord-015021-pol2qm74	398	20	show	show	VB
cord-015021-pol2qm74	398	21	the	the	DT
cord-015021-pol2qm74	398	22	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	398	23	effect	effect	NN
cord-015021-pol2qm74	398	24	.	.	.
cord-015021-pol2qm74	399	1	The	the	DT
cord-015021-pol2qm74	399	2	bioglycans	bioglycan	NNS
cord-015021-pol2qm74	399	3	enhance	enhance	VBP
cord-015021-pol2qm74	399	4	the	the	DT
cord-015021-pol2qm74	399	5	resistance	resistance	NN
cord-015021-pol2qm74	399	6	of	of	IN
cord-015021-pol2qm74	399	7	mice	mouse	NNS
cord-015021-pol2qm74	399	8	to	to	IN
cord-015021-pol2qm74	399	9	the	the	DT
cord-015021-pol2qm74	399	10	lethal	lethal	JJ
cord-015021-pol2qm74	399	11	effect	effect	NN
cord-015021-pol2qm74	399	12	of	of	IN
cord-015021-pol2qm74	399	13	laDS	laDS	NNP
cord-015021-pol2qm74	399	14	and	and	CC
cord-015021-pol2qm74	399	15	provide	provide	VB
cord-015021-pol2qm74	399	16	protection	protection	NN
cord-015021-pol2qm74	399	17	59	59	CD
cord-015021-pol2qm74	399	18	-	-	SYM
cord-015021-pol2qm74	399	19	75	75	CD
cord-015021-pol2qm74	399	20	%	%	NN
cord-015021-pol2qm74	399	21	of	of	IN
cord-015021-pol2qm74	399	22	mice	mouse	NNS
cord-015021-pol2qm74	399	23	.	.	.
cord-015021-pol2qm74	400	1	One	one	CD
cord-015021-pol2qm74	400	2	opens	open	VBZ
cord-015021-pol2qm74	400	3	possibility	possibility	NN
cord-015021-pol2qm74	400	4	to	to	IN
cord-015021-pol2qm74	400	5	use	use	NN
cord-015021-pol2qm74	400	6	of	of	IN
cord-015021-pol2qm74	400	7	bioglicans	bioglican	NNS
cord-015021-pol2qm74	400	8	for	for	IN
cord-015021-pol2qm74	400	9	reduction	reduction	NN
cord-015021-pol2qm74	400	10	of	of	IN
cord-015021-pol2qm74	400	11	toxinemia	toxinemia	NN
cord-015021-pol2qm74	400	12	in	in	IN
cord-015021-pol2qm74	400	13	generalizated	generalizated	NNP
cord-015021-pol2qm74	400	14	forms	form	NNS
cord-015021-pol2qm74	400	15	of	of	IN
cord-015021-pol2qm74	400	16	pseudotuberculosis	pseudotuberculosis	NN
cord-015021-pol2qm74	400	17	.	.	.
cord-015021-pol2qm74	401	1	Thus	thus	RB
cord-015021-pol2qm74	401	2	,	,	,
cord-015021-pol2qm74	401	3	LPS	LPS	NNP
cord-015021-pol2qm74	401	4	from	from	IN
cord-015021-pol2qm74	401	5	Y.pseudotuberculosis	Y.pseudotuberculosis	NNP
cord-015021-pol2qm74	401	6	is	be	VBZ
cord-015021-pol2qm74	401	7	immunogen	immunogen	NN
cord-015021-pol2qm74	401	8	and	and	CC
cord-015021-pol2qm74	401	9	immunomodulator	immunomodulator	NNP
cord-015021-pol2qm74	401	10	wich	wich	NNP
cord-015021-pol2qm74	401	11	has	have	VBZ
cord-015021-pol2qm74	401	12	influence	influence	NN
cord-015021-pol2qm74	401	13	on	on	IN
cord-015021-pol2qm74	401	14	humoral	humoral	JJ
cord-015021-pol2qm74	401	15	and	and	CC
cord-015021-pol2qm74	401	16	cellular	cellular	JJ
cord-015021-pol2qm74	401	17	factors	factor	NNS
cord-015021-pol2qm74	401	18	of	of	IN
cord-015021-pol2qm74	401	19	immunity	immunity	NN
cord-015021-pol2qm74	401	20	and	and	CC
cord-015021-pol2qm74	401	21	plays	play	VBZ
cord-015021-pol2qm74	401	22	the	the	DT
cord-015021-pol2qm74	401	23	important	important	JJ
cord-015021-pol2qm74	401	24	role	role	NN
cord-015021-pol2qm74	401	25	in	in	IN
cord-015021-pol2qm74	401	26	immunopathogenesis	immunopathogenesis	NN
cord-015021-pol2qm74	401	27	of	of	IN
cord-015021-pol2qm74	401	28	infection	infection	NN
cord-015021-pol2qm74	401	29	.	.	.
cord-015021-pol2qm74	401	30	 	 	_SP
cord-015021-pol2qm74	402	1	Endotoxaemia	Endotoxaemia	NNP
cord-015021-pol2qm74	402	2	is	be	VBZ
cord-015021-pol2qm74	402	3	implicated	implicate	VBN
cord-015021-pol2qm74	402	4	in	in	IN
cord-015021-pol2qm74	402	5	the	the	DT
cord-015021-pol2qm74	402	6	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	402	7	of	of	IN
cord-015021-pol2qm74	402	8	obstructive	obstructive	JJ
cord-015021-pol2qm74	402	9	jaundice	jaundice	NN
cord-015021-pol2qm74	402	10	.	.	.
cord-015021-pol2qm74	403	1	The	the	DT
cord-015021-pol2qm74	403	2	Lirnulus	Lirnulus	NNP
cord-015021-pol2qm74	403	3	lysate	lysate	NN
cord-015021-pol2qm74	403	4	(	(	-LRB-
cord-015021-pol2qm74	403	5	LAL	LAL	NNP
cord-015021-pol2qm74	403	6	)	)	-RRB-
cord-015021-pol2qm74	403	7	assay	assay	NN
cord-015021-pol2qm74	403	8	is	be	VBZ
cord-015021-pol2qm74	403	9	the	the	DT
cord-015021-pol2qm74	403	10	gold	gold	JJ
cord-015021-pol2qm74	403	11	standard	standard	JJ
cord-015021-pol2qm74	403	12	method	method	NN
cord-015021-pol2qm74	403	13	for	for	IN
cord-015021-pol2qm74	403	14	measuring	measure	VBG
cord-015021-pol2qm74	403	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	403	16	concentrations	concentration	NNS
cord-015021-pol2qm74	403	17	,	,	,
cord-015021-pol2qm74	403	18	but	but	CC
cord-015021-pol2qm74	403	19	inherent	inherent	JJ
cord-015021-pol2qm74	403	20	biochemical	biochemical	JJ
cord-015021-pol2qm74	403	21	and	and	CC
cord-015021-pol2qm74	403	22	technical	technical	JJ
cord-015021-pol2qm74	403	23	problems	problem	NNS
cord-015021-pol2qm74	403	24	limit	limit	VBP
cord-015021-pol2qm74	403	25	the	the	DT
cord-015021-pol2qm74	403	26	usefulness	usefulness	NN
cord-015021-pol2qm74	403	27	of	of	IN
cord-015021-pol2qm74	403	28	this	this	DT
cord-015021-pol2qm74	403	29	assay	assay	NN
cord-015021-pol2qm74	403	30	.	.	.
cord-015021-pol2qm74	404	1	The	the	DT
cord-015021-pol2qm74	404	2	EndoCab	EndoCab	NNP
cord-015021-pol2qm74	404	3	ELISA	ELISA	NNP
cord-015021-pol2qm74	404	4	is	be	VBZ
cord-015021-pol2qm74	404	5	a	a	DT
cord-015021-pol2qm74	404	6	novel	novel	JJ
cord-015021-pol2qm74	404	7	assay	assay	NN
cord-015021-pol2qm74	404	8	which	which	WDT
cord-015021-pol2qm74	404	9	measures	measure	VBZ
cord-015021-pol2qm74	404	10	endogenous	endogenous	JJ
cord-015021-pol2qm74	404	11	antibody	antibody	NN
cord-015021-pol2qm74	404	12	(	(	-LRB-
cord-015021-pol2qm74	404	13	IgG	IgG	NNP
cord-015021-pol2qm74	404	14	)	)	-RRB-
cord-015021-pol2qm74	404	15	to	to	IN
cord-015021-pol2qm74	404	16	the	the	DT
cord-015021-pol2qm74	404	17	inner	inner	JJ
cord-015021-pol2qm74	404	18	core	core	NN
cord-015021-pol2qm74	404	19	region	region	NN
cord-015021-pol2qm74	404	20	of	of	IN
cord-015021-pol2qm74	404	21	circulating	circulate	VBG
cord-015021-pol2qm74	404	22	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	404	23	(	(	-LRB-
cord-015021-pol2qm74	404	24	ACGA	ACGA	NNP
cord-015021-pol2qm74	404	25	)	)	-RRB-
cord-015021-pol2qm74	404	26	.	.	.
cord-015021-pol2qm74	405	1	Objectives	objective	NNS
cord-015021-pol2qm74	406	1	We	-PRON-	PRP
cord-015021-pol2qm74	406	2	evaluated	evaluate	VBD
cord-015021-pol2qm74	406	3	the	the	DT
cord-015021-pol2qm74	406	4	significance	significance	NN
cord-015021-pol2qm74	406	5	of	of	IN
cord-015021-pol2qm74	406	6	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	406	7	in	in	IN
cord-015021-pol2qm74	406	8	biliary	biliary	JJ
cord-015021-pol2qm74	406	9	obstruction	obstruction	NN
cord-015021-pol2qm74	406	10	using	use	VBG
cord-015021-pol2qm74	406	11	the	the	DT
cord-015021-pol2qm74	406	12	EndoCab	EndoCab	NNP
cord-015021-pol2qm74	406	13	assay	assay	NN
cord-015021-pol2qm74	406	14	and	and	CC
cord-015021-pol2qm74	406	15	subsequently	subsequently	RB
cord-015021-pol2qm74	406	16	the	the	DT
cord-015021-pol2qm74	406	17	specificity	specificity	NN
cord-015021-pol2qm74	406	18	of	of	IN
cord-015021-pol2qm74	406	19	the	the	DT
cord-015021-pol2qm74	406	20	humoral	humoral	JJ
cord-015021-pol2qm74	406	21	response	response	NN
cord-015021-pol2qm74	406	22	to	to	TO
cord-015021-pol2qm74	406	23	endotoxin	endotoxin	NN
cord-015021-pol2qm74	406	24	compared	compare	VBN
cord-015021-pol2qm74	406	25	with	with	IN
cord-015021-pol2qm74	406	26	an	an	DT
cord-015021-pol2qm74	406	27	exogenous	exogenous	JJ
cord-015021-pol2qm74	406	28	antigenic	antigenic	JJ
cord-015021-pol2qm74	406	29	challenge	challenge	NN
cord-015021-pol2qm74	406	30	[	[	-LRB-
cord-015021-pol2qm74	406	31	Tetamls	Tetamls	NNP
cord-015021-pol2qm74	406	32	Toxoid	Toxoid	NNP
cord-015021-pol2qm74	406	33	(	(	-LRB-
cord-015021-pol2qm74	406	34	TT	TT	NNP
cord-015021-pol2qm74	406	35	)	)	-RRB-
cord-015021-pol2qm74	406	36	]	]	-RRB-
cord-015021-pol2qm74	406	37	.	.	.
cord-015021-pol2qm74	407	1	Materials	material	NNS
cord-015021-pol2qm74	407	2	and	and	CC
cord-015021-pol2qm74	407	3	methods	method	NNS
cord-015021-pol2qm74	407	4	In	in	IN
cord-015021-pol2qm74	407	5	Experiment	experiment	NN
cord-015021-pol2qm74	408	1	I	-PRON-	PRP
cord-015021-pol2qm74	408	2	three	three	CD
cord-015021-pol2qm74	408	3	groups	group	NNS
cord-015021-pol2qm74	408	4	of	of	IN
cord-015021-pol2qm74	408	5	male	male	JJ
cord-015021-pol2qm74	408	6	Wistar	Wistar	NNP
cord-015021-pol2qm74	408	7	rats	rat	NNS
cord-015021-pol2qm74	408	8	(	(	-LRB-
cord-015021-pol2qm74	408	9	250	250	CD
cord-015021-pol2qm74	408	10	-	-	SYM
cord-015021-pol2qm74	408	11	300	300	CD
cord-015021-pol2qm74	408	12	g	g	NN
cord-015021-pol2qm74	408	13	)	)	-RRB-
cord-015021-pol2qm74	408	14	were	be	VBD
cord-015021-pol2qm74	408	15	studied	study	VBN
cord-015021-pol2qm74	408	16	[	[	-LRB-
cord-015021-pol2qm74	408	17	No	no	DT
cord-015021-pol2qm74	408	18	operation	operation	NN
cord-015021-pol2qm74	408	19	(	(	-LRB-
cord-015021-pol2qm74	408	20	n=39	n=39	NNP
cord-015021-pol2qm74	408	21	)	)	-RRB-
cord-015021-pol2qm74	408	22	,	,	,
cord-015021-pol2qm74	408	23	Sham	Sham	NNP
cord-015021-pol2qm74	408	24	operation	operation	NN
cord-015021-pol2qm74	408	25	(	(	-LRB-
cord-015021-pol2qm74	408	26	n=40	n=40	NNP
cord-015021-pol2qm74	408	27	)	)	-RRB-
cord-015021-pol2qm74	408	28	,	,	,
cord-015021-pol2qm74	408	29	and	and	CC
cord-015021-pol2qm74	408	30	Bile	bile	NN
cord-015021-pol2qm74	408	31	Duct	duct	NN
cord-015021-pol2qm74	408	32	Ligation	ligation	NN
cord-015021-pol2qm74	408	33	for	for	IN
cord-015021-pol2qm74	408	34	21	21	CD
cord-015021-pol2qm74	408	35	days	day	NNS
cord-015021-pol2qm74	408	36	(	(	-LRB-
cord-015021-pol2qm74	408	37	BDL)(n=50	BDL)(n=50	NNP
cord-015021-pol2qm74	408	38	)	)	-RRB-
cord-015021-pol2qm74	408	39	]	]	-RRB-
cord-015021-pol2qm74	408	40	.	.	.
cord-015021-pol2qm74	409	1	Plasma	plasma	NN
cord-015021-pol2qm74	409	2	was	be	VBD
cord-015021-pol2qm74	409	3	collected	collect	VBN
cord-015021-pol2qm74	409	4	and	and	CC
cord-015021-pol2qm74	409	5	assayed	assay	VBN
cord-015021-pol2qm74	409	6	for	for	IN
cord-015021-pol2qm74	409	7	Bilirubin	bilirubin	NN
cord-015021-pol2qm74	409	8	,	,	,
cord-015021-pol2qm74	409	9	Endntoxin(LAL	Endntoxin(LAL	NNP
cord-015021-pol2qm74	409	10	)	)	-RRB-
cord-015021-pol2qm74	409	11	and	and	CC
cord-015021-pol2qm74	409	12	ACGA(EndoCab	ACGA(EndoCab	NNP
cord-015021-pol2qm74	409	13	)	)	-RRB-
cord-015021-pol2qm74	409	14	.	.	.
cord-015021-pol2qm74	410	1	In	in	IN
cord-015021-pol2qm74	410	2	Experiment	Experiment	NNP
cord-015021-pol2qm74	410	3	II	II	NNP
cord-015021-pol2qm74	410	4	30	30	CD
cord-015021-pol2qm74	410	5	rats	rat	NNS
cord-015021-pol2qm74	410	6	were	be	VBD
cord-015021-pol2qm74	410	7	actively	actively	RB
cord-015021-pol2qm74	410	8	immunised	immunise	VBN
cord-015021-pol2qm74	410	9	with	with	IN
cord-015021-pol2qm74	410	10	Tetanus	Tetanus	NNP
cord-015021-pol2qm74	410	11	Toxoid	Toxoid	NNP
cord-015021-pol2qm74	410	12	(	(	-LRB-
cord-015021-pol2qm74	410	13	'	'	''
cord-015021-pol2qm74	410	14	IT	it	NN
cord-015021-pol2qm74	410	15	)	)	-RRB-
cord-015021-pol2qm74	410	16	and	and	CC
cord-015021-pol2qm74	410	17	then	then	RB
cord-015021-pol2qm74	410	18	randomised	randomise	VBD
cord-015021-pol2qm74	410	19	to	to	TO
cord-015021-pol2qm74	410	20	have	have	VB
cord-015021-pol2qm74	410	21	No	no	DT
cord-015021-pol2qm74	410	22	op(n=8	op(n=8	NN
cord-015021-pol2qm74	410	23	)	)	-RRB-
cord-015021-pol2qm74	410	24	,	,	,
cord-015021-pol2qm74	410	25	Sham	Sham	NNP
cord-015021-pol2qm74	410	26	op(n=8	op(n=8	NNP
cord-015021-pol2qm74	410	27	)	)	-RRB-
cord-015021-pol2qm74	410	28	or	or	CC
cord-015021-pol2qm74	410	29	BDL(n	bdl(n	NN
cord-015021-pol2qm74	410	30	=	=	SYM
cord-015021-pol2qm74	410	31	I4	I4	NNP
cord-015021-pol2qm74	410	32	)	)	-RRB-
cord-015021-pol2qm74	410	33	.	.	.
cord-015021-pol2qm74	411	1	Blood	blood	NN
cord-015021-pol2qm74	411	2	was	be	VBD
cord-015021-pol2qm74	411	3	taken	take	VBN
cord-015021-pol2qm74	411	4	at	at	IN
cord-015021-pol2qm74	411	5	this	this	DT
cord-015021-pol2qm74	411	6	time	time	NN
cord-015021-pol2qm74	411	7	(	(	-LRB-
cord-015021-pol2qm74	411	8	To	to	IN
cord-015021-pol2qm74	411	9	)	)	-RRB-
cord-015021-pol2qm74	411	10	and	and	CC
cord-015021-pol2qm74	411	11	21	21	CD
cord-015021-pol2qm74	411	12	days	day	NNS
cord-015021-pol2qm74	411	13	later(T20	later(t20	WDT
cord-015021-pol2qm74	411	14	at	at	IN
cord-015021-pol2qm74	411	15	sacrifice	sacrifice	NN
cord-015021-pol2qm74	411	16	for	for	IN
cord-015021-pol2qm74	411	17	ACGA	ACGA	NNP
cord-015021-pol2qm74	411	18	concentrationslEndoCab	concentrationslEndoCab	NNP
cord-015021-pol2qm74	411	19	]	]	-RRB-
cord-015021-pol2qm74	411	20	and	and	CC
cord-015021-pol2qm74	411	21	IgG	IgG	NNP
cord-015021-pol2qm74	411	22	Produced	produce	VBD
cord-015021-pol2qm74	411	23	to	to	IN
cord-015021-pol2qm74	411	24	TT(TTab	TT(TTab	NNP
cord-015021-pol2qm74	411	25	)	)	-RRB-
cord-015021-pol2qm74	412	1	[	[	-LRB-
cord-015021-pol2qm74	412	2	ELISA	ELISA	NNP
cord-015021-pol2qm74	412	3	]	]	-RRB-
cord-015021-pol2qm74	412	4	.	.	.
cord-015021-pol2qm74	413	1	Antibody	antibody	NN
cord-015021-pol2qm74	413	2	concentrations	concentration	NNS
cord-015021-pol2qm74	413	3	are	be	VBP
cord-015021-pol2qm74	413	4	expressed	express	VBN
cord-015021-pol2qm74	413	5	as	as	IN
cord-015021-pol2qm74	413	6	%	%	NN
cord-015021-pol2qm74	413	7	increase	increase	NN
cord-015021-pol2qm74	413	8	from	from	IN
cord-015021-pol2qm74	413	9	control	control	NN
cord-015021-pol2qm74	413	10	values	value	NNS
cord-015021-pol2qm74	413	11	.	.	.
cord-015021-pol2qm74	414	1	Results	result	NNS
cord-015021-pol2qm74	414	2	In	in	IN
cord-015021-pol2qm74	414	3	BDL	BDL	NNP
cord-015021-pol2qm74	414	4	rats	rat	NNS
cord-015021-pol2qm74	415	1	,	,	,
cord-015021-pol2qm74	415	2	ACGA	ACGA	NNP
cord-015021-pol2qm74	415	3	concentrations	concentration	NNS
cord-015021-pol2qm74	415	4	were	be	VBD
cord-015021-pol2qm74	415	5	significantly	significantly	RB
cord-015021-pol2qm74	415	6	increased	increase	VBN
cord-015021-pol2qm74	415	7	compared	compare	VBN
cord-015021-pol2qm74	415	8	with	with	IN
cord-015021-pol2qm74	415	9	controlslP<0.001	controlslP<0.001	NNP
cord-015021-pol2qm74	415	10	,	,	,
cord-015021-pol2qm74	415	11	Mann	Mann	NNP
cord-015021-pol2qm74	415	12	-	-	HYPH
cord-015021-pol2qm74	415	13	Whitney	Whitney	NNP
cord-015021-pol2qm74	415	14	]	]	-RRB-
cord-015021-pol2qm74	415	15	.	.	.
cord-015021-pol2qm74	416	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	416	2	concentrations	concentration	NNS
cord-015021-pol2qm74	416	3	were	be	VBD
cord-015021-pol2qm74	416	4	sporadically	sporadically	RB
cord-015021-pol2qm74	416	5	elevated	elevate	VBN
cord-015021-pol2qm74	416	6	in	in	IN
cord-015021-pol2qm74	416	7	the	the	DT
cord-015021-pol2qm74	416	8	jaundiced	jaundiced	JJ
cord-015021-pol2qm74	416	9	rats	rat	NNS
cord-015021-pol2qm74	416	10	but	but	CC
cord-015021-pol2qm74	416	11	the	the	DT
cord-015021-pol2qm74	416	12	rise	rise	NN
cord-015021-pol2qm74	416	13	was	be	VBD
cord-015021-pol2qm74	416	14	not	not	RB
cord-015021-pol2qm74	416	15	significant	significant	JJ
cord-015021-pol2qm74	416	16	.	.	.
cord-015021-pol2qm74	417	1	In	in	IN
cord-015021-pol2qm74	417	2	Experiment	experiment	NN
cord-015021-pol2qm74	417	3	[	[	-LRB-
cord-015021-pol2qm74	417	4	I	-PRON-	PRP
cord-015021-pol2qm74	417	5	there	there	EX
cord-015021-pol2qm74	417	6	was	be	VBD
cord-015021-pol2qm74	417	7	no	no	DT
cord-015021-pol2qm74	417	8	difference	difference	NN
cord-015021-pol2qm74	417	9	between	between	IN
cord-015021-pol2qm74	417	10	the	the	DT
cord-015021-pol2qm74	417	11	ACGA	ACGA	NNP
cord-015021-pol2qm74	417	12	or	or	CC
cord-015021-pol2qm74	417	13	TTab	TTab	NNP
cord-015021-pol2qm74	417	14	concentrations	concentration	NNS
cord-015021-pol2qm74	417	15	in	in	IN
cord-015021-pol2qm74	417	16	the	the	DT
cord-015021-pol2qm74	417	17	fllree	fllree	NNP
cord-015021-pol2qm74	417	18	groups	group	NNS
cord-015021-pol2qm74	417	19	at	at	IN
cord-015021-pol2qm74	417	20	To	To	NNP
cord-015021-pol2qm74	417	21	,	,	,
cord-015021-pol2qm74	417	22	BDL	BDL	NNP
cord-015021-pol2qm74	417	23	rats	rat	NNS
cord-015021-pol2qm74	417	24	had	have	VBD
cord-015021-pol2qm74	417	25	a	a	DT
cord-015021-pol2qm74	417	26	significant	significant	JJ
cord-015021-pol2qm74	417	27	rise	rise	NN
cord-015021-pol2qm74	417	28	in	in	IN
cord-015021-pol2qm74	417	29	ACGA	ACGA	NNP
cord-015021-pol2qm74	417	30	concentrations	concentration	NNS
cord-015021-pol2qm74	417	31	by	by	IN
cord-015021-pol2qm74	417	32	T21	T21	NNP
cord-015021-pol2qm74	417	33	[	[	-LRB-
cord-015021-pol2qm74	417	34	P<0,001,paired	p<0,001,paired	JJ
cord-015021-pol2qm74	417	35	t	t	NN
cord-015021-pol2qm74	417	36	-	-	HYPH
cord-015021-pol2qm74	417	37	test	test	NN
cord-015021-pol2qm74	417	38	]	]	-RRB-
cord-015021-pol2qm74	417	39	and	and	CC
cord-015021-pol2qm74	417	40	humoral	humoral	JJ
cord-015021-pol2qm74	417	41	response	response	NN
cord-015021-pol2qm74	417	42	to	to	IN
cord-015021-pol2qm74	417	43	TT	TT	NNP
cord-015021-pol2qm74	417	44	was	be	VBD
cord-015021-pol2qm74	417	45	significantly	significantly	RB
cord-015021-pol2qm74	417	46	impaired	impair	VBN
cord-015021-pol2qm74	417	47	in	in	IN
cord-015021-pol2qm74	417	48	BDL	BDL	NNP
cord-015021-pol2qm74	417	49	rats	rat	NNS
cord-015021-pol2qm74	417	50	compared	compare	VBN
cord-015021-pol2qm74	417	51	with	with	IN
cord-015021-pol2qm74	417	52	control	control	NN
cord-015021-pol2qm74	417	53	groupslP<0.05	groupslP<0.05	NNP
cord-015021-pol2qm74	417	54	,	,	,
cord-015021-pol2qm74	417	55	paired	pair	VBN
cord-015021-pol2qm74	417	56	ttest	ttest	NNP
cord-015021-pol2qm74	418	1	Data	Data	NNP
cord-015021-pol2qm74	418	2	Plasma	Plasma	NNP
cord-015021-pol2qm74	418	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	418	4	was	be	VBD
cord-015021-pol2qm74	418	5	measured	measure	VBN
cord-015021-pol2qm74	418	6	by	by	IN
cord-015021-pol2qm74	418	7	means	mean	NNS
cord-015021-pol2qm74	418	8	of	of	IN
cord-015021-pol2qm74	418	9	an	an	DT
cord-015021-pol2qm74	418	10	endotoxinspecific	endotoxinspecific	JJ
cord-015021-pol2qm74	418	11	Endospecy	Endospecy	NNP
cord-015021-pol2qm74	418	12	test	test	NN
cord-015021-pol2qm74	418	13	after	after	IN
cord-015021-pol2qm74	418	14	pretreatment	pretreatment	NN
cord-015021-pol2qm74	418	15	of	of	IN
cord-015021-pol2qm74	418	16	the	the	DT
cord-015021-pol2qm74	418	17	plasma	plasma	NN
cord-015021-pol2qm74	418	18	with	with	IN
cord-015021-pol2qm74	418	19	a	a	DT
cord-015021-pol2qm74	418	20	new	new	JJ
cord-015021-pol2qm74	418	21	perchloric	perchloric	JJ
cord-015021-pol2qm74	418	22	acid	acid	NN
cord-015021-pol2qm74	418	23	method	method	NN
cord-015021-pol2qm74	418	24	that	that	WDT
cord-015021-pol2qm74	418	25	we	-PRON-	PRP
cord-015021-pol2qm74	418	26	developed	develop	VBD
cord-015021-pol2qm74	418	27	.	.	.
cord-015021-pol2qm74	419	1	The	the	DT
cord-015021-pol2qm74	419	2	normal	normal	JJ
cord-015021-pol2qm74	419	3	value	value	NN
cord-015021-pol2qm74	419	4	of	of	IN
cord-015021-pol2qm74	419	5	plasma	plasma	NN
cord-015021-pol2qm74	419	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	419	7	is	be	VBZ
cord-015021-pol2qm74	419	8	less	less	JJR
cord-015021-pol2qm74	419	9	than	than	IN
cord-015021-pol2qm74	419	10	9.8	9.8	CD
cord-015021-pol2qm74	419	11	pglml	pglml	NNS
cord-015021-pol2qm74	419	12	.	.	.
cord-015021-pol2qm74	420	1	Polymyxin	Polymyxin	NNP
cord-015021-pol2qm74	420	2	B	B	NNP
cord-015021-pol2qm74	420	3	was	be	VBD
cord-015021-pol2qm74	420	4	administered	administer	VBN
cord-015021-pol2qm74	420	5	at	at	IN
cord-015021-pol2qm74	420	6	a	a	DT
cord-015021-pol2qm74	420	7	dose	dose	NN
cord-015021-pol2qm74	420	8	of	of	IN
cord-015021-pol2qm74	420	9	12,500	12,500	CD
cord-015021-pol2qm74	420	10	U	u	NN
cord-015021-pol2qm74	420	11	every	every	DT
cord-015021-pol2qm74	420	12	6	6	CD
cord-015021-pol2qm74	420	13	hours	hour	NNS
cord-015021-pol2qm74	420	14	.	.	.
cord-015021-pol2qm74	421	1	Plasma	plasma	NN
cord-015021-pol2qm74	421	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	421	3	rapidly	rapidly	RB
cord-015021-pol2qm74	421	4	decreased	decrease	VBD
cord-015021-pol2qm74	421	5	to	to	IN
cord-015021-pol2qm74	421	6	the	the	DT
cord-015021-pol2qm74	421	7	normal	normal	JJ
cord-015021-pol2qm74	421	8	range	range	NN
cord-015021-pol2qm74	421	9	in	in	IN
cord-015021-pol2qm74	421	10	40	40	CD
cord-015021-pol2qm74	421	11	of	of	IN
cord-015021-pol2qm74	421	12	the	the	DT
cord-015021-pol2qm74	421	13	42	42	CD
cord-015021-pol2qm74	421	14	patients	patient	NNS
cord-015021-pol2qm74	421	15	.	.	.
cord-015021-pol2qm74	422	1	Body	body	NN
cord-015021-pol2qm74	422	2	temperature	temperature	NN
cord-015021-pol2qm74	422	3	fall	fall	VBP
cord-015021-pol2qm74	422	4	significantly	significantly	RB
cord-015021-pol2qm74	422	5	.	.	.
cord-015021-pol2qm74	423	1	APACHE	APACHE	NNP
cord-015021-pol2qm74	423	2	II	II	NNP
cord-015021-pol2qm74	423	3	scores	score	NNS
cord-015021-pol2qm74	423	4	were	be	VBD
cord-015021-pol2qm74	423	5	also	also	RB
cord-015021-pol2qm74	423	6	significantly	significantly	RB
cord-015021-pol2qm74	423	7	improved	improve	VBN
cord-015021-pol2qm74	423	8	.	.	.
cord-015021-pol2qm74	424	1	Tumor	tumor	NN
cord-015021-pol2qm74	424	2	necrosis	necrosis	NN
cord-015021-pol2qm74	424	3	factor	factor	NN
cord-015021-pol2qm74	424	4	-	-	HYPH
cord-015021-pol2qm74	424	5	o~	o~	XX
cord-015021-pol2qm74	424	6	and	and	CC
cord-015021-pol2qm74	424	7	interleukin	interleukin	NN
cord-015021-pol2qm74	424	8	6	6	CD
cord-015021-pol2qm74	424	9	decreased	decrease	VBD
cord-015021-pol2qm74	424	10	in	in	IN
cord-015021-pol2qm74	424	11	survivors	survivor	NNS
cord-015021-pol2qm74	424	12	,	,	,
cord-015021-pol2qm74	424	13	while	while	IN
cord-015021-pol2qm74	424	14	in	in	IN
cord-015021-pol2qm74	424	15	high	high	JJ
cord-015021-pol2qm74	424	16	values	value	NNS
cord-015021-pol2qm74	424	17	tended	tend	VBD
cord-015021-pol2qm74	424	18	to	to	TO
cord-015021-pol2qm74	424	19	persist	persist	VB
cord-015021-pol2qm74	424	20	in	in	IN
cord-015021-pol2qm74	424	21	patients	patient	NNS
cord-015021-pol2qm74	424	22	died	die	VBD
cord-015021-pol2qm74	424	23	.	.	.
cord-015021-pol2qm74	425	1	No	no	DT
cord-015021-pol2qm74	425	2	side	side	NN
cord-015021-pol2qm74	425	3	effects	effect	NNS
cord-015021-pol2qm74	425	4	were	be	VBD
cord-015021-pol2qm74	425	5	observed	observe	VBN
cord-015021-pol2qm74	425	6	in	in	IN
cord-015021-pol2qm74	425	7	any	any	DT
cord-015021-pol2qm74	425	8	of	of	IN
cord-015021-pol2qm74	425	9	the	the	DT
cord-015021-pol2qm74	425	10	patients	patient	NNS
cord-015021-pol2qm74	425	11	.	.	.
cord-015021-pol2qm74	426	1	In	in	IN
cord-015021-pol2qm74	426	2	conclusion	conclusion	NN
cord-015021-pol2qm74	426	3	,	,	,
cord-015021-pol2qm74	426	4	intramuscular	intramuscular	JJ
cord-015021-pol2qm74	426	5	injection	injection	NN
cord-015021-pol2qm74	426	6	of	of	IN
cord-015021-pol2qm74	426	7	minute	minute	NN
cord-015021-pol2qm74	426	8	of	of	IN
cord-015021-pol2qm74	426	9	Polymyxin	Polymyxin	NNP
cord-015021-pol2qm74	426	10	B	B	NNP
cord-015021-pol2qm74	426	11	was	be	VBD
cord-015021-pol2qm74	426	12	useful	useful	JJ
cord-015021-pol2qm74	426	13	in	in	IN
cord-015021-pol2qm74	426	14	the	the	DT
cord-015021-pol2qm74	426	15	treatment	treatment	NN
cord-015021-pol2qm74	426	16	of	of	IN
cord-015021-pol2qm74	426	17	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	426	18	.	.	.
cord-015021-pol2qm74	427	1	19	19	CD
cord-015021-pol2qm74	427	2	-	-	SYM
cord-015021-pol2qm74	427	3	1	1	CD
cord-015021-pol2qm74	427	4	Uchimaru	Uchimaru	NNP
cord-015021-pol2qm74	427	5	,	,	,
cord-015021-pol2qm74	427	6	Morioka	Morioka	NNP
cord-015021-pol2qm74	427	7	020	020	CD
cord-015021-pol2qm74	427	8	,	,	,
cord-015021-pol2qm74	427	9	Japan	Japan	NNP
cord-015021-pol2qm74	427	10	.	.	.
cord-015021-pol2qm74	428	1	l	l	NN
cord-015021-pol2qm74	428	2	e	e	NN
cord-015021-pol2qm74	428	3	v	v	NN
cord-015021-pol2qm74	428	4	a	a	NN
cord-015021-pol2qm74	428	5	n	n	NN
cord-015021-pol2qm74	428	6	t	t	NN
cord-015021-pol2qm74	428	7	G	g	NN
cord-015021-pol2qm74	428	8	r	r	NN
cord-015021-pol2qm74	428	9	a	a	DT
cord-015021-pol2qm74	428	10	m	m	NN
cord-015021-pol2qm74	428	11	n	n	NN
cord-015021-pol2qm74	428	12	e	e	NN
cord-015021-pol2qm74	428	13	g	g	NN
cord-015021-pol2qm74	428	14	a	a	DT
cord-015021-pol2qm74	428	15	t	t	NN
cord-015021-pol2qm74	429	1	i	i	PRP
cord-015021-pol2qm74	429	2	v	v	IN
cord-015021-pol2qm74	429	3	organisms	organism	NNS
cord-015021-pol2qm74	429	4	.	.	.
cord-015021-pol2qm74	430	1	M	m	NN
cord-015021-pol2qm74	430	2	e	e	NN
cord-015021-pol2qm74	430	3	t	t	NN
cord-015021-pol2qm74	430	4	h	h	NN
cord-015021-pol2qm74	430	5	o	o	NN
cord-015021-pol2qm74	430	6	d	d	NN
cord-015021-pol2qm74	430	7	s	s	NN
cord-015021-pol2qm74	430	8	:	:	:
cord-015021-pol2qm74	430	9	U	U	NNP
cord-015021-pol2qm74	430	10	n	n	NN
cord-015021-pol2qm74	430	11	d	d	NN
cord-015021-pol2qm74	430	12	e	e	NNP
cord-015021-pol2qm74	430	13	r	r	NNP
cord-015021-pol2qm74	430	14	general	general	NNP
cord-015021-pol2qm74	430	15	anesthesia	anesthesia	NNP
cord-015021-pol2qm74	430	16	,	,	,
cord-015021-pol2qm74	431	1	12	12	CD
cord-015021-pol2qm74	431	2	N	n	NN
cord-015021-pol2qm74	431	3	o	o	NN
cord-015021-pol2qm74	431	4	r	r	NN
cord-015021-pol2qm74	431	5	w	w	NN
cord-015021-pol2qm74	431	6	e	e	NN
cord-015021-pol2qm74	431	7	g	g	NN
cord-015021-pol2qm74	432	1	i	i	PRP
cord-015021-pol2qm74	433	1	a	a	DT
cord-015021-pol2qm74	433	2	n	n	NN
cord-015021-pol2qm74	433	3	b	b	NN
cord-015021-pol2qm74	433	4	r	r	NN
cord-015021-pol2qm74	433	5	e	e	NN
cord-015021-pol2qm74	433	6	d	d	NN
cord-015021-pol2qm74	433	7	landrace	landrace	NN
cord-015021-pol2qm74	433	8	pigs	pig	NNS
cord-015021-pol2qm74	433	9	(	(	-LRB-
cord-015021-pol2qm74	433	10	17	17	CD
cord-015021-pol2qm74	433	11	-	-	SYM
cord-015021-pol2qm74	433	12	30	30	CD
cord-015021-pol2qm74	433	13	kg	kg	NNP
cord-015021-pol2qm74	433	14	)	)	-RRB-
cord-015021-pol2qm74	433	15	of	of	IN
cord-015021-pol2qm74	433	16	either	either	DT
cord-015021-pol2qm74	433	17	sex	sex	NN
cord-015021-pol2qm74	433	18	,	,	,
cord-015021-pol2qm74	433	19	6	6	CD
cord-015021-pol2qm74	433	20	pr	pr	NN
cord-015021-pol2qm74	433	21	group	group	NN
cord-015021-pol2qm74	433	22	,	,	,
cord-015021-pol2qm74	434	1	u	u	NNP
cord-015021-pol2qm74	434	2	n	n	NNP
cord-015021-pol2qm74	434	3	d	d	NNP
cord-015021-pol2qm74	434	4	e	e	NN
cord-015021-pol2qm74	435	1	r	r	LS
cord-015021-pol2qm74	436	1	w	w	NNP
cord-015021-pol2qm74	436	2	e	e	NN
cord-015021-pol2qm74	436	3	n	n	NN
cord-015021-pol2qm74	436	4	t	t	NNP
cord-015021-pol2qm74	436	5	t	t	NN
cord-015021-pol2qm74	437	1	r	r	LS
cord-015021-pol2qm74	437	2	a	a	DT
cord-015021-pol2qm74	437	3	c	c	NN
cord-015021-pol2qm74	437	4	h	h	NN
cord-015021-pol2qm74	438	1	e	e	LS
cord-015021-pol2qm74	438	2	o	o	NN
cord-015021-pol2qm74	439	1	s	s	NNP
cord-015021-pol2qm74	440	1	t	t	NNP
cord-015021-pol2qm74	440	2	o	o	NNP
cord-015021-pol2qm74	441	1	m	m	NNP
cord-015021-pol2qm74	441	2	y	y	NNP
cord-015021-pol2qm74	442	1	a	a	DT
cord-015021-pol2qm74	442	2	n	n	NNP
cord-015021-pol2qm74	442	3	d	d	NNP
cord-015021-pol2qm74	442	4	w	w	NN
cord-015021-pol2qm74	442	5	e	e	NN
cord-015021-pol2qm74	442	6	r	r	NN
cord-015021-pol2qm74	442	7	e	e	NN
cord-015021-pol2qm74	442	8	v	v	NN
cord-015021-pol2qm74	443	1	e	e	LS
cord-015021-pol2qm74	443	2	n	n	NN
cord-015021-pol2qm74	443	3	t	t	NN
cord-015021-pol2qm74	444	1	i	i	PRP
cord-015021-pol2qm74	444	2	l	l	NNP
cord-015021-pol2qm74	444	3	a	a	DT
cord-015021-pol2qm74	444	4	t	t	NN
cord-015021-pol2qm74	444	5	e	e	NN
cord-015021-pol2qm74	444	6	d	d	NN
cord-015021-pol2qm74	444	7	on	on	IN
cord-015021-pol2qm74	444	8	a	a	DT
cord-015021-pol2qm74	444	9	50/50	50/50	CD
cord-015021-pol2qm74	444	10	air	air	NN
cord-015021-pol2qm74	445	1	a	a	LS
cord-015021-pol2qm74	446	1	n	n	NNP
cord-015021-pol2qm74	446	2	d	d	NNP
cord-015021-pol2qm74	447	1	o	o	UH
cord-015021-pol2qm74	448	1	x	x	SYM
cord-015021-pol2qm74	448	2	y	y	NNP
cord-015021-pol2qm74	448	3	g	g	NN
cord-015021-pol2qm74	449	1	e	e	NN
cord-015021-pol2qm74	449	2	n	n	NN
cord-015021-pol2qm74	449	3	m	m	NNP
cord-015021-pol2qm74	450	1	i	i	PRP
cord-015021-pol2qm74	451	1	x	x	LS
cord-015021-pol2qm74	452	1	t	t	NNP
cord-015021-pol2qm74	452	2	u	u	NNP
cord-015021-pol2qm74	452	3	r	r	NN
cord-015021-pol2qm74	452	4	e	e	NN
cord-015021-pol2qm74	453	1	a	a	DT
cord-015021-pol2qm74	453	2	i	i	NN
cord-015021-pol2qm74	453	3	m	m	NN
cord-015021-pol2qm74	453	4	e	e	NN
cord-015021-pol2qm74	453	5	d	d	NN
cord-015021-pol2qm74	453	6	at	at	IN
cord-015021-pol2qm74	453	7	m	m	NNP
cord-015021-pol2qm74	454	1	a	a	DT
cord-015021-pol2qm74	454	2	i	i	NN
cord-015021-pol2qm74	454	3	n	n	NN
cord-015021-pol2qm74	454	4	t	t	NN
cord-015021-pol2qm74	455	1	a	a	LS
cord-015021-pol2qm74	456	1	i	i	PRP
cord-015021-pol2qm74	456	2	n	n	CC
cord-015021-pol2qm74	456	3	i	i	NNP
cord-015021-pol2qm74	456	4	n	n	CC
cord-015021-pol2qm74	456	5	g	g	NNP
cord-015021-pol2qm74	456	6	a	a	NNP
cord-015021-pol2qm74	456	7	n	n	NN
cord-015021-pol2qm74	456	8	o	o	NN
cord-015021-pol2qm74	456	9	r	r	NN
cord-015021-pol2qm74	456	10	m	m	NN
cord-015021-pol2qm74	456	11	a	a	NN
cord-015021-pol2qm74	456	12	l	l	NN
cord-015021-pol2qm74	456	13	p	p	NN
cord-015021-pol2qm74	456	14	H	h	NN
cord-015021-pol2qm74	456	15	a	a	NN
cord-015021-pol2qm74	456	16	n	n	NN
cord-015021-pol2qm74	456	17	d	d	NN
cord-015021-pol2qm74	456	18	a	a	DT
cord-015021-pol2qm74	456	19	isocapnic	isocapnic	JJ
cord-015021-pol2qm74	456	20	level	level	NN
cord-015021-pol2qm74	456	21	.	.	.
cord-015021-pol2qm74	457	1	Ventilation	ventilation	NN
cord-015021-pol2qm74	457	2	w	w	NN
cord-015021-pol2qm74	458	1	a	a	DT
cord-015021-pol2qm74	458	2	s	s	NN
cord-015021-pol2qm74	458	3	not	not	RB
cord-015021-pol2qm74	458	4	readjusted	readjust	VBN
cord-015021-pol2qm74	459	1	d	d	NNP
cord-015021-pol2qm74	460	1	u	u	NNP
cord-015021-pol2qm74	460	2	r	r	NNP
cord-015021-pol2qm74	460	3	i	i	NN
cord-015021-pol2qm74	460	4	n	n	CC
cord-015021-pol2qm74	460	5	g	g	NNP
cord-015021-pol2qm74	460	6	the	the	DT
cord-015021-pol2qm74	460	7	observation	observation	NN
cord-015021-pol2qm74	460	8	period	period	NN
cord-015021-pol2qm74	460	9	.	.	.
cord-015021-pol2qm74	461	1	The	the	DT
cord-015021-pol2qm74	461	2	anesthesia	anesthesia	NN
cord-015021-pol2qm74	461	3	w	w	NNP
cord-015021-pol2qm74	461	4	a	a	DT
cord-015021-pol2qm74	461	5	s	s	NN
cord-015021-pol2qm74	462	1	K	K	NNP
cord-015021-pol2qm74	462	2	e	e	NN
cord-015021-pol2qm74	462	3	t	t	NN
cord-015021-pol2qm74	462	4	a	a	DT
cord-015021-pol2qm74	462	5	m	m	NNP
cord-015021-pol2qm74	462	6	i	i	NN
cord-015021-pol2qm74	462	7	n	n	NN
cord-015021-pol2qm74	462	8	e	e	NN
cord-015021-pol2qm74	462	9	0.6	0.6	CD
cord-015021-pol2qm74	462	10	m	m	NN
cord-015021-pol2qm74	462	11	g	g	NN
cord-015021-pol2qm74	462	12	/	/	,
cord-015021-pol2qm74	463	1	k	k	NNP
cord-015021-pol2qm74	464	1	g	g	NNP
cord-015021-pol2qm74	464	2	h	h	NNP
cord-015021-pol2qm74	465	1	a	a	DT
cord-015021-pol2qm74	465	2	n	n	NN
cord-015021-pol2qm74	465	3	d	d	NN
cord-015021-pol2qm74	465	4	D	d	NN
cord-015021-pol2qm74	465	5	i	i	NN
cord-015021-pol2qm74	465	6	a	a	DT
cord-015021-pol2qm74	465	7	z	z	NN
cord-015021-pol2qm74	465	8	e	e	NN
cord-015021-pol2qm74	465	9	p	p	NN
cord-015021-pol2qm74	465	10	a	a	DT
cord-015021-pol2qm74	465	11	m	m	NNP
cord-015021-pol2qm74	465	12	2.4	2.4	CD
cord-015021-pol2qm74	465	13	m	m	NN
cord-015021-pol2qm74	465	14	g	g	NN
cord-015021-pol2qm74	465	15	/	/	,
cord-015021-pol2qm74	466	1	k	k	NNP
cord-015021-pol2qm74	467	1	g	g	NNP
cord-015021-pol2qm74	467	2	h	h	NNP
cord-015021-pol2qm74	468	1	i	i	PRP
cord-015021-pol2qm74	468	2	n	n	CC
cord-015021-pol2qm74	468	3	t	t	NNP
cord-015021-pol2qm74	468	4	r	r	NNP
cord-015021-pol2qm74	468	5	a	a	NN
cord-015021-pol2qm74	468	6	v	v	NN
cord-015021-pol2qm74	468	7	e	e	NN
cord-015021-pol2qm74	468	8	n	n	NN
cord-015021-pol2qm74	468	9	o	o	NN
cord-015021-pol2qm74	468	10	u	u	NN
cord-015021-pol2qm74	468	11	s	s	NNP
cord-015021-pol2qm74	468	12	l	l	NNP
cord-015021-pol2qm74	468	13	y	y	NNP
cord-015021-pol2qm74	468	14	.	.	.
cord-015021-pol2qm74	469	1	H	h	NN
cord-015021-pol2qm74	469	2	e	e	NN
cord-015021-pol2qm74	469	3	m	m	NN
cord-015021-pol2qm74	469	4	o	o	NN
cord-015021-pol2qm74	469	5	d	d	NN
cord-015021-pol2qm74	470	1	y	y	NNP
cord-015021-pol2qm74	470	2	n	n	NNP
cord-015021-pol2qm74	471	1	a	a	DT
cord-015021-pol2qm74	471	2	m	m	NN
cord-015021-pol2qm74	471	3	i	i	NN
cord-015021-pol2qm74	472	1	c	c	NNP
cord-015021-pol2qm74	473	1	m	m	LS
cord-015021-pol2qm74	473	2	o	o	NN
cord-015021-pol2qm74	474	1	n	n	NNP
cord-015021-pol2qm74	475	1	i	i	PRP
cord-015021-pol2qm74	476	1	t	t	NNP
cord-015021-pol2qm74	477	1	o	o	UH
cord-015021-pol2qm74	477	2	r	r	NN
cord-015021-pol2qm74	477	3	i	i	NN
cord-015021-pol2qm74	477	4	n	n	NN
cord-015021-pol2qm74	477	5	g	g	NNP
cord-015021-pol2qm74	477	6	of	of	IN
cord-015021-pol2qm74	477	7	m	m	NNP
cord-015021-pol2qm74	477	8	e	e	NNP
cord-015021-pol2qm74	477	9	a	a	NNP
cord-015021-pol2qm74	477	10	n	n	NN
cord-015021-pol2qm74	477	11	aorta	aorta	NN
cord-015021-pol2qm74	477	12	,	,	.
cord-015021-pol2qm74	478	1	p	p	NN
cord-015021-pol2qm74	478	2	u	u	NN
cord-015021-pol2qm74	478	3	l	l	NN
cord-015021-pol2qm74	478	4	m	m	NN
cord-015021-pol2qm74	478	5	o	o	NN
cord-015021-pol2qm74	478	6	n	n	NN
cord-015021-pol2qm74	478	7	a	a	DT
cord-015021-pol2qm74	478	8	r	r	NN
cord-015021-pol2qm74	478	9	y	y	NNP
cord-015021-pol2qm74	478	10	artery	artery	NN
cord-015021-pol2qm74	478	11	,	,	,
cord-015021-pol2qm74	478	12	central	central	NNP
cord-015021-pol2qm74	478	13	v	v	NN
cord-015021-pol2qm74	478	14	e	e	NN
cord-015021-pol2qm74	478	15	n	n	NN
cord-015021-pol2qm74	478	16	o	o	NN
cord-015021-pol2qm74	478	17	u	u	NNP
cord-015021-pol2qm74	478	18	s	s	NNP
cord-015021-pol2qm74	478	19	a	a	NNP
cord-015021-pol2qm74	478	20	n	n	NN
cord-015021-pol2qm74	478	21	d	d	NN
cord-015021-pol2qm74	478	22	p	p	NN
cord-015021-pol2qm74	479	1	u	u	NNP
cord-015021-pol2qm74	479	2	l	l	NNP
cord-015021-pol2qm74	479	3	m	m	NN
cord-015021-pol2qm74	480	1	o	o	UH
cord-015021-pol2qm74	480	2	n	n	NN
cord-015021-pol2qm74	481	1	a	a	DT
cord-015021-pol2qm74	481	2	r	r	NNP
cord-015021-pol2qm74	481	3	y	y	NN
cord-015021-pol2qm74	481	4	capillary	capillary	NN
cord-015021-pol2qm74	482	1	w	w	NNP
cord-015021-pol2qm74	482	2	e	e	NN
cord-015021-pol2qm74	482	3	d	d	NN
cord-015021-pol2qm74	482	4	g	g	NN
cord-015021-pol2qm74	482	5	e	e	NN
cord-015021-pol2qm74	482	6	pressures	pressure	NNS
cord-015021-pol2qm74	482	7	w	w	NNP
cord-015021-pol2qm74	482	8	a	a	DT
cord-015021-pol2qm74	482	9	s	s	NN
cord-015021-pol2qm74	482	10	p	p	NN
cord-015021-pol2qm74	482	11	e	e	NN
cord-015021-pol2qm74	482	12	r	r	NN
cord-015021-pol2qm74	482	13	f	f	NN
cord-015021-pol2qm74	483	1	o	o	UH
cord-015021-pol2qm74	483	2	r	r	NN
cord-015021-pol2qm74	483	3	m	m	NN
cord-015021-pol2qm74	483	4	e	e	NN
cord-015021-pol2qm74	483	5	d	d	NN
cord-015021-pol2qm74	484	1	w	w	NNP
cord-015021-pol2qm74	484	2	i	i	PRP
cord-015021-pol2qm74	484	3	t	t	NN
cord-015021-pol2qm74	484	4	h	h	NN
cord-015021-pol2qm74	485	1	a	a	DT
cord-015021-pol2qm74	485	2	5F	5F	NNP
cord-015021-pol2qm74	485	3	S	S	NNP
cord-015021-pol2qm74	485	4	w	w	NNP
cord-015021-pol2qm74	485	5	a	a	DT
cord-015021-pol2qm74	485	6	n	n	XX
cord-015021-pol2qm74	485	7	-G	-G	:
cord-015021-pol2qm74	485	8	a	a	NN
cord-015021-pol2qm74	485	9	n	n	NN
cord-015021-pol2qm74	485	10	z	z	NNP
cord-015021-pol2qm74	485	11	catheter	catheter	NN
cord-015021-pol2qm74	485	12	a	a	DT
cord-015021-pol2qm74	485	13	n	n	NN
cord-015021-pol2qm74	485	14	d	d	NN
cord-015021-pol2qm74	485	15	an	an	DT
cord-015021-pol2qm74	485	16	aorta	aorta	JJ
cord-015021-pol2qm74	485	17	catheter	catheter	NN
cord-015021-pol2qm74	485	18	.	.	.
cord-015021-pol2qm74	486	1	A	a	DT
cord-015021-pol2qm74	486	2	continous	continous	JJ
cord-015021-pol2qm74	486	3	infusion	infusion	NN
cord-015021-pol2qm74	486	4	of	of	IN
cord-015021-pol2qm74	486	5	R	r	NN
cord-015021-pol2qm74	486	6	i	i	NN
cord-015021-pol2qm74	486	7	n	n	NN
cord-015021-pol2qm74	486	8	g	g	NN
cord-015021-pol2qm74	486	9	e	e	NN
cord-015021-pol2qm74	486	10	r	r	NN
cord-015021-pol2qm74	486	11	'	'	''
cord-015021-pol2qm74	486	12	s	s	NN
cord-015021-pol2qm74	486	13	acetate	acetate	NN
cord-015021-pol2qm74	486	14	(	(	-LRB-
cord-015021-pol2qm74	486	15	1	1	CD
cord-015021-pol2qm74	486	16	0	0	CD
cord-015021-pol2qm74	486	17	m	m	NN
cord-015021-pol2qm74	486	18	l	l	NN
cord-015021-pol2qm74	486	19	/	/	SYM
cord-015021-pol2qm74	486	20	k	k	NN
cord-015021-pol2qm74	486	21	g	g	NN
cord-015021-pol2qm74	486	22	h	h	NN
cord-015021-pol2qm74	486	23	)	)	-RRB-
cord-015021-pol2qm74	487	1	w	w	NNP
cord-015021-pol2qm74	488	1	a	a	DT
cord-015021-pol2qm74	488	2	s	s	NN
cord-015021-pol2qm74	488	3	g	g	NN
cord-015021-pol2qm74	489	1	i	i	PRP
cord-015021-pol2qm74	489	2	v	v	NN
cord-015021-pol2qm74	490	1	e	e	LS
cord-015021-pol2qm74	490	2	n	n	NNP
cord-015021-pol2qm74	490	3	intravenously	intravenously	RB
cord-015021-pol2qm74	490	4	.	.	.
cord-015021-pol2qm74	491	1	W	w	NN
cord-015021-pol2qm74	491	2	h	h	NN
cord-015021-pol2qm74	491	3	e	e	NN
cord-015021-pol2qm74	491	4	n	n	NN
cord-015021-pol2qm74	491	5	stabilised	stabilise	VBD
cord-015021-pol2qm74	491	6	,	,	,
cord-015021-pol2qm74	491	7	the	the	DT
cord-015021-pol2qm74	491	8	a	a	NNP
cord-015021-pol2qm74	491	9	n	n	NN
cord-015021-pol2qm74	491	10	i	i	NN
cord-015021-pol2qm74	491	11	m	m	NNP
cord-015021-pol2qm74	491	12	a	a	NNP
cord-015021-pol2qm74	491	13	l	l	NNP
cord-015021-pol2qm74	491	14	s	s	NNP
cord-015021-pol2qm74	491	15	w	w	NN
cord-015021-pol2qm74	491	16	e	e	NN
cord-015021-pol2qm74	491	17	r	r	NN
cord-015021-pol2qm74	491	18	e	e	NN
cord-015021-pol2qm74	491	19	g	g	NN
cord-015021-pol2qm74	492	1	i	i	PRP
cord-015021-pol2qm74	492	2	v	v	NN
cord-015021-pol2qm74	493	1	e	e	LS
cord-015021-pol2qm74	493	2	n	n	NN
cord-015021-pol2qm74	493	3	2.5	2.5	CD
cord-015021-pol2qm74	493	4	x	x	SYM
cord-015021-pol2qm74	493	5	l09	l09	CD
cord-015021-pol2qm74	493	6	CFU	CFU	NNP
cord-015021-pol2qm74	493	7	of	of	IN
cord-015021-pol2qm74	493	8	E	E	NNP
cord-015021-pol2qm74	493	9	Colt	Colt	NNP
cord-015021-pol2qm74	493	10	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	493	11	as	as	IN
cord-015021-pol2qm74	493	12	a	a	DT
cord-015021-pol2qm74	493	13	bolus	bolus	NN
cord-015021-pol2qm74	493	14	in	in	IN
cord-015021-pol2qm74	493	15	100ml	100ml	JJ
cord-015021-pol2qm74	493	16	saline	saline	NN
cord-015021-pol2qm74	493	17	,	,	,
cord-015021-pol2qm74	493	18	the	the	DT
cord-015021-pol2qm74	493	19	a	a	NN
cord-015021-pol2qm74	493	20	n	n	NN
cord-015021-pol2qm74	493	21	t	t	NN
cord-015021-pol2qm74	493	22	i	i	NN
cord-015021-pol2qm74	493	23	b	b	NN
cord-015021-pol2qm74	493	24	o	o	NN
cord-015021-pol2qm74	493	25	d	d	NN
cord-015021-pol2qm74	494	1	y	y	NNP
cord-015021-pol2qm74	494	2	g	g	NNP
cord-015021-pol2qm74	494	3	r	r	NN
cord-015021-pol2qm74	495	1	o	o	UH
cord-015021-pol2qm74	495	2	u	u	NN
cord-015021-pol2qm74	495	3	p	p	NN
cord-015021-pol2qm74	495	4	received	receive	VBD
cord-015021-pol2qm74	495	5	in	in	IN
cord-015021-pol2qm74	495	6	a	a	DT
cord-015021-pol2qm74	495	7	d	d	NN
cord-015021-pol2qm74	495	8	d	d	NN
cord-015021-pol2qm74	496	1	i	i	PRP
cord-015021-pol2qm74	496	2	t	t	NNP
cord-015021-pol2qm74	497	1	i	i	PRP
cord-015021-pol2qm74	497	2	o	o	NN
cord-015021-pol2qm74	497	3	n	n	NN
cord-015021-pol2qm74	497	4	5	5	CD
cord-015021-pol2qm74	497	5	m	m	NN
cord-015021-pol2qm74	498	1	g	g	NNP
cord-015021-pol2qm74	498	2	/	/	SYM
cord-015021-pol2qm74	498	3	k	k	NNP
cord-015021-pol2qm74	498	4	g	g	NN
cord-015021-pol2qm74	498	5	E5	E5	NNP
cord-015021-pol2qm74	498	6	a	a	DT
cord-015021-pol2qm74	498	7	n	n	NN
cord-015021-pol2qm74	498	8	t	t	NN
cord-015021-pol2qm74	499	1	i	i	PRP
cord-015021-pol2qm74	500	1	e	e	NNP
cord-015021-pol2qm74	500	2	n	n	NN
cord-015021-pol2qm74	500	3	d	d	NN
cord-015021-pol2qm74	500	4	o	o	NN
cord-015021-pol2qm74	501	1	t	t	NNP
cord-015021-pol2qm74	502	1	o	o	UH
cord-015021-pol2qm74	503	1	x	x	LS
cord-015021-pol2qm74	504	1	i	i	PRP
cord-015021-pol2qm74	505	1	n	n	NNP
cord-015021-pol2qm74	505	2	i	i	NNP
cord-015021-pol2qm74	505	3	n	n	NNP
cord-015021-pol2qm74	506	1	t	t	NNP
cord-015021-pol2qm74	506	2	r	r	NNP
cord-015021-pol2qm74	506	3	a	a	NN
cord-015021-pol2qm74	506	4	v	v	NN
cord-015021-pol2qm74	506	5	e	e	NN
cord-015021-pol2qm74	506	6	n	n	NN
cord-015021-pol2qm74	506	7	o	o	NN
cord-015021-pol2qm74	507	1	u	u	NNP
cord-015021-pol2qm74	507	2	s	s	NNP
cord-015021-pol2qm74	507	3	l	l	NNP
cord-015021-pol2qm74	507	4	y	y	NNP
cord-015021-pol2qm74	507	5	over	over	IN
cord-015021-pol2qm74	507	6	1	1	CD
cord-015021-pol2qm74	507	7	h	h	NN
cord-015021-pol2qm74	507	8	o	o	NN
cord-015021-pol2qm74	508	1	u	u	NNP
cord-015021-pol2qm74	508	2	r	r	NNP
cord-015021-pol2qm74	508	3	via	via	IN
cord-015021-pol2qm74	508	4	a	a	DT
cord-015021-pol2qm74	508	5	n	n	NN
cord-015021-pol2qm74	508	6	infusion	infusion	NN
cord-015021-pol2qm74	508	7	p	p	NN
cord-015021-pol2qm74	508	8	u	u	NN
cord-015021-pol2qm74	508	9	m	m	NN
cord-015021-pol2qm74	508	10	p	p	NN
cord-015021-pol2qm74	508	11	at	at	IN
cord-015021-pol2qm74	508	12	the	the	DT
cord-015021-pol2qm74	508	13	start	start	NN
cord-015021-pol2qm74	508	14	of	of	IN
cord-015021-pol2qm74	508	15	the	the	DT
cord-015021-pol2qm74	508	16	observation	observation	NN
cord-015021-pol2qm74	508	17	period	period	NN
cord-015021-pol2qm74	508	18	.	.	.
cord-015021-pol2qm74	509	1	The	the	DT
cord-015021-pol2qm74	509	2	a	a	DT
cord-015021-pol2qm74	509	3	n	n	NN
cord-015021-pol2qm74	509	4	i	i	NN
cord-015021-pol2qm74	509	5	m	m	NNP
cord-015021-pol2qm74	509	6	a	a	NNP
cord-015021-pol2qm74	509	7	l	l	NNP
cord-015021-pol2qm74	509	8	s	s	NNP
cord-015021-pol2qm74	509	9	w	w	NN
cord-015021-pol2qm74	509	10	e	e	NN
cord-015021-pol2qm74	509	11	r	r	NN
cord-015021-pol2qm74	509	12	e	e	NNP
cord-015021-pol2qm74	509	13	observed	observe	VBD
cord-015021-pol2qm74	509	14	for	for	IN
cord-015021-pol2qm74	509	15	6	6	CD
cord-015021-pol2qm74	509	16	hours	hour	NNS
cord-015021-pol2qm74	509	17	.	.	.
cord-015021-pol2qm74	510	1	Results	result	NNS
cord-015021-pol2qm74	510	2	:	:	:
cord-015021-pol2qm74	511	1	A	a	DT
cord-015021-pol2qm74	511	2	t	t	NN
cord-015021-pol2qm74	511	3	5	5	CD
cord-015021-pol2qm74	512	1	a	a	DT
cord-015021-pol2qm74	512	2	n	n	NN
cord-015021-pol2qm74	512	3	d	d	NN
cord-015021-pol2qm74	512	4	6	6	CD
cord-015021-pol2qm74	512	5	hours	hour	NNS
cord-015021-pol2qm74	512	6	,	,	,
cord-015021-pol2qm74	512	7	the	the	DT
cord-015021-pol2qm74	512	8	o	o	NN
cord-015021-pol2qm74	512	9	x	x	SYM
cord-015021-pol2qm74	512	10	y	y	NNP
cord-015021-pol2qm74	512	11	g	g	NN
cord-015021-pol2qm74	512	12	e	e	NN
cord-015021-pol2qm74	512	13	n	n	NN
cord-015021-pol2qm74	512	14	c	c	NN
cord-015021-pol2qm74	513	1	o	o	UH
cord-015021-pol2qm74	513	2	n	n	NN
cord-015021-pol2qm74	514	1	s	s	NNP
cord-015021-pol2qm74	515	1	u	u	NNP
cord-015021-pol2qm74	515	2	m	m	NN
cord-015021-pol2qm74	515	3	p	p	NN
cord-015021-pol2qm74	515	4	t	t	NN
cord-015021-pol2qm74	516	1	i	i	PRP
cord-015021-pol2qm74	516	2	o	o	NN
cord-015021-pol2qm74	516	3	n	n	NN
cord-015021-pol2qm74	516	4	increased	increase	VBD
cord-015021-pol2qm74	516	5	by	by	IN
cord-015021-pol2qm74	516	6	30	30	CD
cord-015021-pol2qm74	516	7	%	%	NN
cord-015021-pol2qm74	516	8	in	in	IN
cord-015021-pol2qm74	516	9	the	the	DT
cord-015021-pol2qm74	516	10	a	a	NNP
cord-015021-pol2qm74	516	11	n	n	NN
cord-015021-pol2qm74	516	12	t	t	NN
cord-015021-pol2qm74	516	13	i	i	NN
cord-015021-pol2qm74	516	14	b	b	NNP
cord-015021-pol2qm74	516	15	o	o	NNP
cord-015021-pol2qm74	516	16	d	d	NNP
cord-015021-pol2qm74	516	17	y	y	NNP
cord-015021-pol2qm74	516	18	treated	treat	VBD
cord-015021-pol2qm74	516	19	g	g	NN
cord-015021-pol2qm74	516	20	r	r	NN
cord-015021-pol2qm74	516	21	o	o	NN
cord-015021-pol2qm74	516	22	u	u	NN
cord-015021-pol2qm74	516	23	p	p	NN
cord-015021-pol2qm74	516	24	w	w	NN
cord-015021-pol2qm74	516	25	h	h	NN
cord-015021-pol2qm74	517	1	e	e	NNP
cord-015021-pol2qm74	517	2	r	r	NNP
cord-015021-pol2qm74	517	3	e	e	NNP
cord-015021-pol2qm74	517	4	a	a	NNP
cord-015021-pol2qm74	517	5	s	s	NN
cord-015021-pol2qm74	517	6	there	there	RB
cord-015021-pol2qm74	518	1	w	w	NNP
cord-015021-pol2qm74	519	1	a	a	DT
cord-015021-pol2qm74	519	2	s	s	NN
cord-015021-pol2qm74	519	3	a	a	DT
cord-015021-pol2qm74	519	4	significant	significant	JJ
cord-015021-pol2qm74	519	5	fall	fall	NN
cord-015021-pol2qm74	519	6	of	of	IN
cord-015021-pol2qm74	519	7	30	30	CD
cord-015021-pol2qm74	519	8	%	%	NN
cord-015021-pol2qm74	519	9	in	in	IN
cord-015021-pol2qm74	519	10	the	the	DT
cord-015021-pol2qm74	519	11	sepsis	sepsis	NN
cord-015021-pol2qm74	519	12	group	group	NN
cord-015021-pol2qm74	519	13	.	.	.
cord-015021-pol2qm74	520	1	In	in	IN
cord-015021-pol2qm74	520	2	the	the	DT
cord-015021-pol2qm74	520	3	a	a	NN
cord-015021-pol2qm74	520	4	n	n	NN
cord-015021-pol2qm74	520	5	t	t	NN
cord-015021-pol2qm74	520	6	i	i	NN
cord-015021-pol2qm74	520	7	b	b	NNP
cord-015021-pol2qm74	520	8	o	o	NNP
cord-015021-pol2qm74	520	9	d	d	NNP
cord-015021-pol2qm74	520	10	y	y	NNP
cord-015021-pol2qm74	520	11	group	group	NN
cord-015021-pol2qm74	520	12	,	,	,
cord-015021-pol2qm74	520	13	the	the	DT
cord-015021-pol2qm74	520	14	arterial	arterial	JJ
cord-015021-pol2qm74	520	15	p	p	NN
cord-015021-pol2qm74	520	16	H	h	NN
cord-015021-pol2qm74	520	17	a	a	NN
cord-015021-pol2qm74	520	18	n	n	NN
cord-015021-pol2qm74	520	19	d	d	NN
cord-015021-pol2qm74	520	20	the	the	DT
cord-015021-pol2qm74	520	21	cardiac	cardiac	JJ
cord-015021-pol2qm74	520	22	index	index	NN
cord-015021-pol2qm74	520	23	were	be	VBD
cord-015021-pol2qm74	520	24	also	also	RB
cord-015021-pol2qm74	520	25	significantly	significantly	RB
cord-015021-pol2qm74	520	26	h	h	NN
cord-015021-pol2qm74	521	1	i	i	PRP
cord-015021-pol2qm74	522	1	g	g	NN
cord-015021-pol2qm74	522	2	h	h	NN
cord-015021-pol2qm74	522	3	e	e	NN
cord-015021-pol2qm74	522	4	r	r	NN
cord-015021-pol2qm74	522	5	at	at	IN
cord-015021-pol2qm74	522	6	the	the	DT
cord-015021-pol2qm74	522	7	s	s	NNP
cord-015021-pol2qm74	522	8	a	a	NN
cord-015021-pol2qm74	522	9	m	m	NN
cord-015021-pol2qm74	522	10	e	e	NN
cord-015021-pol2qm74	522	11	p	p	NN
cord-015021-pol2qm74	522	12	o	o	UH
cord-015021-pol2qm74	522	13	i	i	NN
cord-015021-pol2qm74	522	14	n	n	CC
cord-015021-pol2qm74	522	15	t	t	NNP
cord-015021-pol2qm74	522	16	s	s	NNP
cord-015021-pol2qm74	522	17	in	in	IN
cord-015021-pol2qm74	522	18	time	time	NN
cord-015021-pol2qm74	522	19	.	.	.
cord-015021-pol2qm74	523	1	There	there	EX
cord-015021-pol2qm74	523	2	w	w	IN
cord-015021-pol2qm74	523	3	a	a	DT
cord-015021-pol2qm74	523	4	s	s	NN
cord-015021-pol2qm74	523	5	no	no	DT
cord-015021-pol2qm74	523	6	significant	significant	JJ
cord-015021-pol2qm74	523	7	difference	difference	NN
cord-015021-pol2qm74	523	8	in	in	IN
cord-015021-pol2qm74	523	9	arterial	arterial	JJ
cord-015021-pol2qm74	523	10	pO2	po2	NN
cord-015021-pol2qm74	523	11	.	.	.
cord-015021-pol2qm74	524	1	In	in	IN
cord-015021-pol2qm74	524	2	severe	severe	JJ
cord-015021-pol2qm74	524	3	bacterial	bacterial	JJ
cord-015021-pol2qm74	524	4	infections	infection	NNS
cord-015021-pol2qm74	524	5	it	-PRON-	PRP
cord-015021-pol2qm74	524	6	would	would	MD
cord-015021-pol2qm74	524	7	be	be	VB
cord-015021-pol2qm74	524	8	beneficial	beneficial	JJ
cord-015021-pol2qm74	524	9	to	to	TO
cord-015021-pol2qm74	524	10	neutralize	neutralize	VB
cord-015021-pol2qm74	524	11	the	the	DT
cord-015021-pol2qm74	524	12	plasma	plasma	NN
cord-015021-pol2qm74	524	13	endotoxin	endotoxin	NN
cord-015021-pol2qm74	524	14	content	content	NN
cord-015021-pol2qm74	524	15	with	with	IN
cord-015021-pol2qm74	524	16	complex	complex	JJ
cord-015021-pol2qm74	524	17	forming	form	VBG
cord-015021-pol2qm74	524	18	compounds	compound	NNS
cord-015021-pol2qm74	524	19	.	.	.
cord-015021-pol2qm74	525	1	The	the	DT
cord-015021-pol2qm74	525	2	phenothiazines	phenothiazine	NNS
cord-015021-pol2qm74	525	3	are	be	VBP
cord-015021-pol2qm74	525	4	able	able	JJ
cord-015021-pol2qm74	525	5	to	to	TO
cord-015021-pol2qm74	525	6	form	form	VB
cord-015021-pol2qm74	525	7	complexes	complex	NNS
cord-015021-pol2qm74	525	8	with	with	IN
cord-015021-pol2qm74	525	9	endoto×in	endoto×in	NNP
cord-015021-pol2qm74	525	10	and	and	CC
cord-015021-pol2qm74	525	11	the	the	DT
cord-015021-pol2qm74	525	12	existence	existence	NN
cord-015021-pol2qm74	525	13	of	of	IN
cord-015021-pol2qm74	525	14	these	these	DT
cord-015021-pol2qm74	525	15	complexes	complex	NNS
cord-015021-pol2qm74	525	16	were	be	VBD
cord-015021-pol2qm74	525	17	already	already	RB
cord-015021-pol2qm74	525	18	shown	show	VBN
cord-015021-pol2qm74	525	19	in	in	IN
cord-015021-pol2qm74	525	20	differential	differential	JJ
cord-015021-pol2qm74	525	21	speetrophotometry	speetrophotometry	NNP
cord-015021-pol2qm74	525	22	and	and	CC
cord-015021-pol2qm74	525	23	animal	animal	NN
cord-015021-pol2qm74	525	24	experiments	experiment	NNS
cord-015021-pol2qm74	525	25	,	,	,
cord-015021-pol2qm74	525	26	however	however	RB
cord-015021-pol2qm74	525	27	,	,	,
cord-015021-pol2qm74	525	28	the	the	DT
cord-015021-pol2qm74	525	29	mechanism	mechanism	NN
cord-015021-pol2qm74	525	30	of	of	IN
cord-015021-pol2qm74	525	31	partial	partial	JJ
cord-015021-pol2qm74	525	32	neutralization	neutralization	NN
cord-015021-pol2qm74	525	33	was	be	VBD
cord-015021-pol2qm74	525	34	not	not	RB
cord-015021-pol2qm74	525	35	clarified	clarify	VBN
cord-015021-pol2qm74	525	36	.	.	.
cord-015021-pol2qm74	526	1	Therefore	therefore	RB
cord-015021-pol2qm74	526	2	some	some	DT
cord-015021-pol2qm74	526	3	representative	representative	JJ
cord-015021-pol2qm74	526	4	phenothiazines	phenothiazine	NNS
cord-015021-pol2qm74	526	5	and	and	CC
cord-015021-pol2qm74	526	6	structurally	structurally	RB
cord-015021-pol2qm74	526	7	related	related	JJ
cord-015021-pol2qm74	526	8	compounds	compound	NNS
cord-015021-pol2qm74	526	9	were	be	VBD
cord-015021-pol2qm74	526	10	tested	test	VBN
cord-015021-pol2qm74	526	11	for	for	IN
cord-015021-pol2qm74	526	12	anti	anti	JJ
cord-015021-pol2qm74	526	13	-	-	JJ
cord-015021-pol2qm74	526	14	endotoxin	endotoxin	JJ
cord-015021-pol2qm74	526	15	activity	activity	NN
cord-015021-pol2qm74	526	16	.	.	.
cord-015021-pol2qm74	527	1	The	the	DT
cord-015021-pol2qm74	527	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	527	3	neutralizinB	neutralizinB	NNP
cord-015021-pol2qm74	527	4	effects	effect	NNS
cord-015021-pol2qm74	527	5	of	of	IN
cord-015021-pol2qm74	527	6	several	several	JJ
cord-015021-pol2qm74	527	7	benzophenothiazines	benzophenothiazine	NNS
cord-015021-pol2qm74	527	8	were	be	VBD
cord-015021-pol2qm74	527	9	investigated	investigate	VBN
cord-015021-pol2qm74	527	10	in	in	IN
cord-015021-pol2qm74	527	11	differential	differential	JJ
cord-015021-pol2qm74	527	12	speotrophotemetry	speotrophotemetry	NNP
cord-015021-pol2qm74	527	13	,	,	,
cord-015021-pol2qm74	527	14	TNF	TNF	NNP
cord-015021-pol2qm74	527	15	induction	induction	NN
cord-015021-pol2qm74	527	16	and	and	CC
cord-015021-pol2qm74	527	17	in	in	IN
cord-015021-pol2qm74	527	18	the	the	DT
cord-015021-pol2qm74	527	19	conventional	conventional	JJ
cord-015021-pol2qm74	527	20	Limulus	Limulus	NNP
cord-015021-pol2qm74	527	21	test	test	NN
cord-015021-pol2qm74	527	22	.	.	.
cord-015021-pol2qm74	528	1	In	in	IN
cord-015021-pol2qm74	528	2	animal	animal	NN
cord-015021-pol2qm74	528	3	experiments	experiment	NNS
cord-015021-pol2qm74	528	4	some	some	DT
cord-015021-pol2qm74	528	5	beneficial	beneficial	JJ
cord-015021-pol2qm74	528	6	effect	effect	NN
cord-015021-pol2qm74	528	7	of	of	IN
cord-015021-pol2qm74	528	8	complex	complex	JJ
cord-015021-pol2qm74	528	9	forming	form	VBG
cord-015021-pol2qm74	528	10	compounds	compound	NNS
cord-015021-pol2qm74	528	11	was	be	VBD
cord-015021-pol2qm74	528	12	found	find	VBN
cord-015021-pol2qm74	528	13	.	.	.
cord-015021-pol2qm74	529	1	The	the	DT
cord-015021-pol2qm74	529	2	benzophenothiazines	benzophenothiazine	NNS
cord-015021-pol2qm74	529	3	were	be	VBD
cord-015021-pol2qm74	529	4	not	not	RB
cord-015021-pol2qm74	529	5	able	able	JJ
cord-015021-pol2qm74	529	6	to	to	TO
cord-015021-pol2qm74	529	7	inactivate	inactivate	VB
cord-015021-pol2qm74	529	8	the	the	DT
cord-015021-pol2qm74	529	9	biological	biological	JJ
cord-015021-pol2qm74	529	10	effect	effect	NN
cord-015021-pol2qm74	529	11	of	of	IN
cord-015021-pol2qm74	529	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	529	13	in	in	IN
cord-015021-pol2qm74	529	14	the	the	DT
cord-015021-pol2qm74	529	15	Limulus	Limulus	NNP
cord-015021-pol2qm74	529	16	test	test	NN
cord-015021-pol2qm74	529	17	.	.	.
cord-015021-pol2qm74	530	1	The	the	DT
cord-015021-pol2qm74	530	2	recent	recent	JJ
cord-015021-pol2qm74	530	3	findings	finding	NNS
cord-015021-pol2qm74	530	4	indicates	indicate	VBZ
cord-015021-pol2qm74	530	5	that	that	IN
cord-015021-pol2qm74	530	6	a	a	DT
cord-015021-pol2qm74	530	7	multifocal	multifocal	JJ
cord-015021-pol2qm74	530	8	effect	effect	NN
cord-015021-pol2qm74	530	9	can	can	MD
cord-015021-pol2qm74	530	10	be	be	VB
cord-015021-pol2qm74	530	11	responsible	responsible	JJ
cord-015021-pol2qm74	530	12	for	for	IN
cord-015021-pol2qm74	530	13	"	"	``
cord-015021-pol2qm74	530	14	anti	anti	JJ
cord-015021-pol2qm74	530	15	-	-	JJ
cord-015021-pol2qm74	530	16	endotoxin	endotoxin	JJ
cord-015021-pol2qm74	530	17	action	action	NN
cord-015021-pol2qm74	530	18	in	in	IN
cord-015021-pol2qm74	530	19	vivo	vivo	NN
cord-015021-pol2qm74	530	20	"	"	''
cord-015021-pol2qm74	530	21	.	.	.
cord-015021-pol2qm74	531	1	Effects	effect	NNS
cord-015021-pol2qm74	531	2	of	of	IN
cord-015021-pol2qm74	531	3	TNF	tnf	NN
cord-015021-pol2qm74	531	4	inducing	induce	VBG
cord-015021-pol2qm74	531	5	effect	effect	NN
cord-015021-pol2qm74	531	6	of	of	IN
cord-015021-pol2qm74	531	7	endotoxin	endotoxin	NN
cord-015021-pol2qm74	531	8	in	in	IN
cord-015021-pol2qm74	531	9	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	531	10	and	and	CC
cord-015021-pol2qm74	531	11	bypotensiv	bypotensiv	JJ
cord-015021-pol2qm74	531	12	action	action	NN
cord-015021-pol2qm74	531	13	in	in	IN
cord-015021-pol2qm74	531	14	experimental	experimental	JJ
cord-015021-pol2qm74	531	15	animals	animal	NNS
cord-015021-pol2qm74	531	16	were	be	VBD
cord-015021-pol2qm74	531	17	reduced	reduce	VBN
cord-015021-pol2qm74	531	18	by	by	IN
cord-015021-pol2qm74	531	19	some	some	DT
cord-015021-pol2qm74	531	20	phenothiazine	phenothiazine	NN
cord-015021-pol2qm74	531	21	derivatives	derivative	NNS
cord-015021-pol2qm74	531	22	.	.	.
cord-015021-pol2qm74	532	1	Monophosphoril	Monophosphoril	NNP
cord-015021-pol2qm74	532	2	lipid	lipid	NN
cord-015021-pol2qm74	532	3	A	A	NNP
cord-015021-pol2qm74	532	4	was	be	VBD
cord-015021-pol2qm74	532	5	without	without	IN
cord-015021-pol2qm74	532	6	effect	effect	NN
cord-015021-pol2qm74	532	7	.	.	.
cord-015021-pol2qm74	533	1	of	of	IN
cord-015021-pol2qm74	533	2	Microbiology	Microbiology	NNP
cord-015021-pol2qm74	533	3	,	,	,
cord-015021-pol2qm74	533	4	Albert	Albert	NNP
cord-015021-pol2qm74	533	5	Szemt	Szemt	NNP
cord-015021-pol2qm74	533	6	-	-	HYPH
cord-015021-pol2qm74	533	7	GydrByi	GydrByi	NNP
cord-015021-pol2qm74	533	8	Medical	Medical	NNP
cord-015021-pol2qm74	533	9	University	University	NNP
cord-015021-pol2qm74	533	10	,	,	,
cord-015021-pol2qm74	534	1	Odm	Odm	NNP
cord-015021-pol2qm74	534	2	t	t	NN
cord-015021-pol2qm74	535	1	~r	~r	NNP
cord-015021-pol2qm74	535	2	lO	lO	NNP
cord-015021-pol2qm74	535	3	,	,	,
cord-015021-pol2qm74	536	1	H-6720	H-6720	NNP
cord-015021-pol2qm74	536	2	Szeged~	Szeged~	.
cord-015021-pol2qm74	537	1	HunBary	hunbary	CD
cord-015021-pol2qm74	537	2	46	46	CD
cord-015021-pol2qm74	537	3	Involvement	Involvement	NNP
cord-015021-pol2qm74	537	4	of	of	IN
cord-015021-pol2qm74	537	5	Streptococcus	streptococcus	NN
cord-015021-pol2qm74	537	6	pyogenes	pyogene	NNS
cord-015021-pol2qm74	537	7	Erythrogenic	Erythrogenic	NNP
cord-015021-pol2qm74	537	8	Toxins	toxin	NNS
cord-015021-pol2qm74	537	9	in	in	IN
cord-015021-pol2qm74	537	10	the	the	DT
cord-015021-pol2qm74	537	11	Induction	Induction	NNP
cord-015021-pol2qm74	537	12	OflStreptococcal	OflStreptococcal	NNP
cord-015021-pol2qm74	537	13	Toxic	Toxic	NNP
cord-015021-pol2qm74	537	14	Shock	Shock	NNP
cord-015021-pol2qm74	537	15	Syndrome	Syndrome	NNP
cord-015021-pol2qm74	537	16	3	3	CD
cord-015021-pol2qm74	538	1	Heide	Heide	NNP
cord-015021-pol2qm74	538	2	Mgller	Mgller	NNP
cord-015021-pol2qm74	538	3	-	-	HYPH
cord-015021-pol2qm74	538	4	Alou~	Alou~	NNP
cord-015021-pol2qm74	539	1	*	*	NFP
cord-015021-pol2qm74	539	2	,	,	,
cord-015021-pol2qm74	539	3	Joseph	Joseph	NNP
cord-015021-pol2qm74	539	4	E.	E.	NNP
cord-015021-pol2qm74	539	5	Alouf	Alouf	NNP
cord-015021-pol2qm74	539	6	,	,	,
cord-015021-pol2qm74	539	7	Die	die	VB
cord-015021-pol2qm74	539	8	[	[	-LRB-
cord-015021-pol2qm74	539	9	er	er	UH
cord-015021-pol2qm74	539	10	Gerlach	Gerlach	NNP
cord-015021-pol2qm74	539	11	,	,	,
cord-015021-pol2qm74	539	12	~atherine	~atherine	NNP
cord-015021-pol2qm74	539	13	Fitting	Fitting	NNP
cord-015021-pol2qm74	539	14	.	.	.
cord-015021-pol2qm74	539	15	,	,	,
cord-015021-pol2qm74	539	16	and	and	CC
cord-015021-pol2qm74	539	17	Jean	Jean	NNP
cord-015021-pol2qm74	539	18	-	-	HYPH
cord-015021-pol2qm74	539	19	Marc	Marc	NNP
cord-015021-pol2qm74	539	20	Ca	Ca	NNP
cord-015021-pol2qm74	539	21	~	~	NFP
cord-015021-pol2qm74	539	22	aillon	aillon	NNP
cord-015021-pol2qm74	539	23	.	.	.
cord-015021-pol2qm74	540	1	Unit6	Unit6	NNP
cord-015021-pol2qm74	540	2	des	des	NNP
cord-015021-pol2qm74	540	3	Toxines	Toxines	NNP
cord-015021-pol2qm74	540	4	Microbiennes	Microbiennes	NNPS
cord-015021-pol2qm74	540	5	and	and	CC
cord-015021-pol2qm74	540	6	"	"	``
cord-015021-pol2qm74	540	7	Unit6	unit6	JJ
cord-015021-pol2qm74	540	8	d'Immuno	d'Immuno	NNP
cord-015021-pol2qm74	540	9	-	-	HYPH
cord-015021-pol2qm74	540	10	Allergie	Allergie	NNP
cord-015021-pol2qm74	540	11	,	,	,
cord-015021-pol2qm74	540	12	Institut	Institut	NNP
cord-015021-pol2qm74	540	13	Pasteur	Pasteur	NNP
cord-015021-pol2qm74	540	14	,	,	,
cord-015021-pol2qm74	540	15	28	28	CD
cord-015021-pol2qm74	540	16	,	,	,
cord-015021-pol2qm74	540	17	rue	rue	FW
cord-015021-pol2qm74	540	18	du	du	FW
cord-015021-pol2qm74	540	19	Docteur	Docteur	NNP
cord-015021-pol2qm74	540	20	Roux	Roux	NNP
cord-015021-pol2qm74	540	21	-75015	-75015	VBZ
cord-015021-pol2qm74	540	22	PARIS	PARIS	NNP
cord-015021-pol2qm74	540	23	(	(	-LRB-
cord-015021-pol2qm74	540	24	France	France	NNP
cord-015021-pol2qm74	540	25	)	)	-RRB-
cord-015021-pol2qm74	540	26	;	;	:
cord-015021-pol2qm74	540	27	Institut	Institut	NNP
cord-015021-pol2qm74	540	28	f	f	NNP
cord-015021-pol2qm74	541	1	~r	~r	XX
cord-015021-pol2qm74	541	2	Experimentelle	Experimentelle	NNP
cord-015021-pol2qm74	541	3	Mikrobiologie	Mikrobiologie	NNP
cord-015021-pol2qm74	541	4	,	,	,
cord-015021-pol2qm74	541	5	JENA	JENA	NNP
cord-015021-pol2qm74	541	6	(	(	-LRB-
cord-015021-pol2qm74	541	7	Germany	Germany	NNP
cord-015021-pol2qm74	541	8	)	)	-RRB-
cord-015021-pol2qm74	541	9	.	.	.
cord-015021-pol2qm74	542	1	superantigen	superantigen	NNP
cord-015021-pol2qm74	542	2	erythrogenic	erythrogenic	NNP
cord-015021-pol2qm74	542	3	toxin	toxin	NN
cord-015021-pol2qm74	542	4	A	a	NN
cord-015021-pol2qm74	542	5	(	(	-LRB-
cord-015021-pol2qm74	542	6	ETA	ETA	NNP
cord-015021-pol2qm74	542	7	)	)	-RRB-
cord-015021-pol2qm74	542	8	is	be	VBZ
cord-015021-pol2qm74	542	9	thought	think	VBN
cord-015021-pol2qm74	542	10	to	to	TO
cord-015021-pol2qm74	542	11	be	be	VB
cord-015021-pol2qm74	542	12	involved	involve	VBN
cord-015021-pol2qm74	542	13	in	in	IN
cord-015021-pol2qm74	542	14	toxic	toxic	JJ
cord-015021-pol2qm74	542	15	shock	shock	NN
cord-015021-pol2qm74	542	16	syndrome	syndrome	NN
cord-015021-pol2qm74	542	17	in	in	IN
cord-015021-pol2qm74	542	18	humans	human	NNS
cord-015021-pol2qm74	542	19	by	by	IN
cord-015021-pol2qm74	542	20	inducing	induce	VBG
cord-015021-pol2qm74	542	21	massive	massive	JJ
cord-015021-pol2qm74	542	22	release	release	NN
cord-015021-pol2qm74	542	23	of	of	IN
cord-015021-pol2qm74	542	24	cytokines	cytokine	NNS
cord-015021-pol2qm74	542	25	by	by	IN
cord-015021-pol2qm74	542	26	patient	patient	JJ
cord-015021-pol2qm74	542	27	immune	immune	JJ
cord-015021-pol2qm74	542	28	cells	cell	NNS
cord-015021-pol2qm74	542	29	.	.	.
cord-015021-pol2qm74	543	1	The	the	DT
cord-015021-pol2qm74	543	2	cytokineinducing	cytokineinducing	NN
cord-015021-pol2qm74	543	3	capacity	capacity	NN
cord-015021-pol2qm74	543	4	of	of	IN
cord-015021-pol2qm74	543	5	ETA	ETA	NNP
cord-015021-pol2qm74	543	6	w~:s	w~:s	''
cord-015021-pol2qm74	543	7	£	£	NN
cord-015021-pol2qm74	543	8	:	:	:
cord-015021-pol2qm74	543	9	ompa	ompa	NNP
cord-015021-pol2qm74	543	10	~	~	NFP
cord-015021-pol2qm74	543	11	ed	ed	NN
cord-015021-pol2qm74	543	12	to	to	IN
cord-015021-pol2qm74	543	13	that	that	DT
cord-015021-pol2qm74	543	14	of	of	IN
cord-015021-pol2qm74	543	15	LPS	LPS	NNP
cord-015021-pol2qm74	543	16	,	,	,
cord-015021-pol2qm74	543	17	a	a	DT
cord-015021-pol2qm74	543	18	gram	gram	NN
cord-015021-pol2qm74	543	19	-	-	HYPH
cord-015021-pol2qm74	543	20	negative	negative	JJ
cord-015021-pol2qm74	543	21	bacterial	bacterial	JJ
cord-015021-pol2qm74	543	22	cell	cell	NN
cord-015021-pol2qm74	543	23	wall	wall	NN
cord-015021-pol2qm74	543	24	component	component	NN
cord-015021-pol2qm74	543	25	.	.	.
cord-015021-pol2qm74	544	1	ETA	ETA	NNP
cord-015021-pol2qm74	544	2	elicited	elicit	VBD
cord-015021-pol2qm74	544	3	weak	weak	JJ
cord-015021-pol2qm74	544	4	production	production	NN
cord-015021-pol2qm74	544	5	of	of	IN
cord-015021-pol2qm74	544	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	544	7	d	d	NNP
cord-015021-pol2qm74	544	8	and	and	CC
cord-015021-pol2qm74	544	9	~	~	NNP
cord-015021-pol2qm74	544	10	,	,	,
cord-015021-pol2qm74	544	11	TNF	TNF	NNP
cord-015021-pol2qm74	544	12	~	~	NFP
cord-015021-pol2qm74	544	13	and	and	CC
cord-015021-pol2qm74	544	14	IL-6	IL-6	NNP
cord-015021-pol2qm74	544	15	in	in	IN
cord-015021-pol2qm74	544	16	purified	purify	VBN
cord-015021-pol2qm74	544	17	human	human	JJ
cord-015021-pol2qm74	544	18	monocytes	monocyte	NNS
cord-015021-pol2qm74	544	19	whereas	whereas	IN
cord-015021-pol2qm74	544	20	LPS	lp	NNS
cord-015021-pol2qm74	544	21	stimulated	stimulate	VBD
cord-015021-pol2qm74	544	22	the	the	DT
cord-015021-pol2qm74	544	23	production	production	NN
cord-015021-pol2qm74	544	24	of	of	IN
cord-015021-pol2qm74	544	25	high	high	JJ
cord-015021-pol2qm74	544	26	amounts	amount	NNS
cord-015021-pol2qm74	544	27	of	of	IN
cord-015021-pol2qm74	544	28	these	these	DT
cord-015021-pol2qm74	544	29	cytokines	cytokine	NNS
cord-015021-pol2qm74	544	30	.	.	.
cord-015021-pol2qm74	545	1	In	in	IN
cord-015021-pol2qm74	545	2	the	the	DT
cord-015021-pol2qm74	545	3	presence	presence	NN
cord-015021-pol2qm74	545	4	of	of	IN
cord-015021-pol2qm74	545	5	T	T	NNP
cord-015021-pol2qm74	545	6	cells	cell	NNS
cord-015021-pol2qm74	545	7	,	,	,
cord-015021-pol2qm74	545	8	ETA	ETA	NNP
cord-015021-pol2qm74	545	9	elicited	elicit	VBD
cord-015021-pol2qm74	545	10	the	the	DT
cord-015021-pol2qm74	545	11	production	production	NN
cord-015021-pol2qm74	545	12	of	of	IN
cord-015021-pol2qm74	545	13	significant	significant	JJ
cord-015021-pol2qm74	545	14	amounts	amount	NNS
cord-015021-pol2qm74	545	15	of	of	IN
cord-015021-pol2qm74	545	16	IL	IL	NNP
cord-015021-pol2qm74	545	17	-	-	HYPH
cord-015021-pol2qm74	545	18	I~	I~	NNP
cord-015021-pol2qm74	545	19	,	,	,
cord-015021-pol2qm74	545	20	IL	IL	NNP
cord-015021-pol2qm74	545	21	-	-	HYPH
cord-015021-pol2qm74	545	22	I~	I~	NNP
cord-015021-pol2qm74	545	23	,	,	,
cord-015021-pol2qm74	545	24	IL-6	IL-6	NNP
cord-015021-pol2qm74	545	25	and	and	CC
cord-015021-pol2qm74	545	26	IL-8	IL-8	NNP
cord-015021-pol2qm74	545	27	.	.	.
cord-015021-pol2qm74	546	1	However	however	RB
cord-015021-pol2qm74	546	2	,	,	,
cord-015021-pol2qm74	546	3	the	the	DT
cord-015021-pol2qm74	546	4	most	most	RBS
cord-015021-pol2qm74	546	5	preponderant	preponderant	JJ
cord-015021-pol2qm74	546	6	cytokine	cytokine	NN
cord-015021-pol2qm74	546	7	was	be	VBD
cord-015021-pol2qm74	546	8	TNF~	tnf~	RB
cord-015021-pol2qm74	546	9	,	,	,
cord-015021-pol2qm74	546	10	which	which	WDT
cord-015021-pol2qm74	546	11	peaked	peak	VBD
cord-015021-pol2qm74	546	12	at	at	IN
cord-015021-pol2qm74	546	13	i0	i0	NNP
cord-015021-pol2qm74	546	14	ng	ng	NNP
cord-015021-pol2qm74	546	15	/	/	SYM
cord-015021-pol2qm74	546	16	ml	ml	NN
cord-015021-pol2qm74	546	17	after	after	IN
cord-015021-pol2qm74	546	18	stimulation	stimulation	NN
cord-015021-pol2qm74	546	19	with	with	IN
cord-015021-pol2qm74	546	20	i0	i0	NNP
cord-015021-pol2qm74	546	21	~g	~g	NNP
cord-015021-pol2qm74	546	22	ETA	ETA	NNP
cord-015021-pol2qm74	546	23	.	.	.
cord-015021-pol2qm74	547	1	Comparable	comparable	JJ
cord-015021-pol2qm74	547	2	amounts	amount	NNS
cord-015021-pol2qm74	547	3	of	of	IN
cord-015021-pol2qm74	547	4	TNFd	TNFd	NNS
cord-015021-pol2qm74	547	5	(	(	-LRB-
cord-015021-pol2qm74	547	6	ca	ca	NNP
cord-015021-pol2qm74	547	7	4	4	CD
cord-015021-pol2qm74	547	8	ng	ng	NNP
cord-015021-pol2qm74	547	9	)	)	-RRB-
cord-015021-pol2qm74	547	10	were	be	VBD
cord-015021-pol2qm74	547	11	induced	induce	VBN
cord-015021-pol2qm74	547	12	by	by	IN
cord-015021-pol2qm74	547	13	0.i	0.i	CD
cord-015021-pol2qm74	548	1	~g	~g	NNP
cord-015021-pol2qm74	549	1	ETA	ETA	NNP
cord-015021-pol2qm74	549	2	and	and	CC
cord-015021-pol2qm74	549	3	0.i	0.i	CD
cord-015021-pol2qm74	550	1	~g	~g	NNP
cord-015021-pol2qm74	551	1	LP$.	LP$.	NNP
cord-015021-pol2qm74	552	1	In	in	IN
cord-015021-pol2qm74	552	2	contrast	contrast	NN
cord-015021-pol2qm74	552	3	to	to	IN
cord-015021-pol2qm74	552	4	LPS	LPS	NNP
cord-015021-pol2qm74	552	5	,	,	,
cord-015021-pol2qm74	552	6	ETA	ETA	NNP
cord-015021-pol2qm74	552	7	was	be	VBD
cord-015021-pol2qm74	552	8	a	a	DT
cord-015021-pol2qm74	552	9	strong	strong	JJ
cord-015021-pol2qm74	552	10	inducer	inducer	NN
cord-015021-pol2qm74	552	11	of	of	IN
cord-015021-pol2qm74	552	12	TNF~	tnf~	CD
cord-015021-pol2qm74	552	13	which	which	WDT
cord-015021-pol2qm74	552	14	was	be	VBD
cord-015021-pol2qm74	552	15	produced	produce	VBN
cord-015021-pol2qm74	552	16	only	only	RB
cord-015021-pol2qm74	552	17	in	in	IN
cord-015021-pol2qm74	552	18	marginal	marginal	JJ
cord-015021-pol2qm74	552	19	amounts	amount	NNS
cord-015021-pol2qm74	552	20	by	by	IN
cord-015021-pol2qm74	552	21	LPS	lp	NNS
cord-015021-pol2qm74	552	22	.	.	.
cord-015021-pol2qm74	553	1	These	these	DT
cord-015021-pol2qm74	553	2	results	result	NNS
cord-015021-pol2qm74	553	3	suggest	suggest	VBP
cord-015021-pol2qm74	553	4	that	that	IN
cord-015021-pol2qm74	553	5	the	the	DT
cord-015021-pol2qm74	553	6	septic	septic	JJ
cord-015021-pol2qm74	553	7	shock	shock	NN
cord-015021-pol2qm74	553	8	induced	induce	VBN
cord-015021-pol2qm74	553	9	by	by	IN
cord-015021-pol2qm74	553	10	gramnegative	gramnegative	JJ
cord-015021-pol2qm74	553	11	bacteria	bacteria	NNS
cord-015021-pol2qm74	553	12	(	(	-LRB-
cord-015021-pol2qm74	553	13	LPS	LPS	NNP
cord-015021-pol2qm74	553	14	)	)	-RRB-
cord-015021-pol2qm74	553	15	and	and	CC
cord-015021-pol2qm74	553	16	by	by	IN
cord-015021-pol2qm74	553	17	gram	gram	NN
cord-015021-pol2qm74	553	18	-	-	HYPH
cord-015021-pol2qm74	553	19	positive	positive	JJ
cord-015021-pol2qm74	553	20	bacteria	bacteria	NNS
cord-015021-pol2qm74	553	21	{	{	-LRB-
cord-015021-pol2qm74	553	22	extracellular	extracellular	JJ
cord-015021-pol2qm74	553	23	superantigens	superantigen	NNS
cord-015021-pol2qm74	553	24	)	)	-RRB-
cord-015021-pol2qm74	553	25	follows	follow	VBZ
cord-015021-pol2qm74	553	26	different	different	JJ
cord-015021-pol2qm74	553	27	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	553	28	pathways	pathway	NNS
cord-015021-pol2qm74	553	29	.	.	.
cord-015021-pol2qm74	554	1	LPS	LPS	NNP
cord-015021-pol2qm74	554	2	-	-	HYPH
cord-015021-pol2qm74	554	3	induced	induce	VBN
cord-015021-pol2qm74	554	4	shock	shock	NN
cord-015021-pol2qm74	554	5	is	be	VBZ
cord-015021-pol2qm74	554	6	mainly	mainly	RB
cord-015021-pol2qm74	554	7	mediated	mediate	VBN
cord-015021-pol2qm74	554	8	by	by	IN
cord-015021-pol2qm74	554	9	monocytes	monocyte	NNS
cord-015021-pol2qm74	554	10	and	and	CC
cord-015021-pol2qm74	554	11	monocyte	monocyte	NNP
cord-015021-pol2qm74	554	12	-	-	HYPH
cord-015021-pol2qm74	554	13	produced	produce	VBN
cord-015021-pol2qm74	554	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	555	1	(	(	-LRB-
cord-015021-pol2qm74	555	2	IL	IL	NNP
cord-015021-pol2qm74	555	3	-	-	HYPH
cord-015021-pol2qm74	555	4	I	I	NNP
cord-015021-pol2qm74	555	5	and	and	CC
cord-015021-pol2qm74	555	6	TNF	TNF	NNP
cord-015021-pol2qm74	555	7	)	)	-RRB-
cord-015021-pol2qm74	555	8	.	.	.
cord-015021-pol2qm74	556	1	The	the	DT
cord-015021-pol2qm74	556	2	ETA	ETA	NNP
cord-015021-pol2qm74	556	3	-	-	HYPH
cord-015021-pol2qm74	556	4	induced	induce	VBN
cord-015021-pol2qm74	556	5	shock	shock	NN
cord-015021-pol2qm74	556	6	is	be	VBZ
cord-015021-pol2qm74	556	7	mediated	mediate	VBN
cord-015021-pol2qm74	556	8	by	by	IN
cord-015021-pol2qm74	556	9	T	T	NNP
cord-015021-pol2qm74	556	10	-	-	HYPH
cord-015021-pol2qm74	556	11	cells	cell	NNS
cord-015021-pol2qm74	556	12	or	or	CC
cord-015021-pol2qm74	556	13	depends	depend	VBZ
cord-015021-pol2qm74	556	14	on	on	IN
cord-015021-pol2qm74	556	15	T	T	NNP
cord-015021-pol2qm74	556	16	cell	cell	NN
cord-015021-pol2qm74	556	17	help	help	NN
cord-015021-pol2qm74	556	18	for	for	IN
cord-015021-pol2qm74	556	19	the	the	DT
cord-015021-pol2qm74	556	20	production	production	NN
cord-015021-pol2qm74	556	21	of	of	IN
cord-015021-pol2qm74	556	22	monocyte	monocyte	NNP
cord-015021-pol2qm74	556	23	-	-	HYPH
cord-015021-pol2qm74	556	24	liberated	liberate	VBN
cord-015021-pol2qm74	556	25	cytokines	cytokine	NNS
cord-015021-pol2qm74	556	26	.	.	.
cord-015021-pol2qm74	557	1	Production	production	NN
cord-015021-pol2qm74	557	2	of	of	IN
cord-015021-pol2qm74	557	3	T	T	NNP
cord-015021-pol2qm74	557	4	cell	cell	NN
cord-015021-pol2qm74	557	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	557	6	such	such	JJ
cord-015021-pol2qm74	557	7	as	as	IN
cord-015021-pol2qm74	557	8	TNF~	tnf~	CD
cord-015021-pol2qm74	557	9	and	and	CC
cord-015021-pol2qm74	557	10	interferon	interferon	NN
cord-015021-pol2qm74	557	11	7	7	CD
cord-015021-pol2qm74	557	12	in	in	IN
cord-015021-pol2qm74	557	13	addition	addition	NN
cord-015021-pol2qm74	557	14	to	to	IN
cord-015021-pol2qm74	557	15	the	the	DT
cord-015021-pol2qm74	557	16	other	other	JJ
cord-015021-pol2qm74	557	17	cytokines	cytokine	NNS
cord-015021-pol2qm74	557	18	contribute	contribute	VBP
cord-015021-pol2qm74	557	19	very	very	RB
cord-015021-pol2qm74	557	20	likely	likely	JJ
cord-015021-pol2qm74	557	21	to	to	IN
cord-015021-pol2qm74	557	22	the	the	DT
cord-015021-pol2qm74	557	23	severity	severity	NN
cord-015021-pol2qm74	557	24	of	of	IN
cord-015021-pol2qm74	557	25	the	the	DT
cord-015021-pol2qm74	557	26	toxic	toxic	JJ
cord-015021-pol2qm74	557	27	-	-	HYPH
cord-015021-pol2qm74	557	28	shock	shock	NN
cord-015021-pol2qm74	557	29	resulting	result	VBG
cord-015021-pol2qm74	557	30	from	from	IN
cord-015021-pol2qm74	557	31	S.	S.	NNP
cord-015021-pol2qm74	557	32	auzeus	auzeu	NNS
cord-015021-pol2qm74	557	33	and	and	CC
cord-015021-pol2qm74	557	34	S.	S.	NNP
cord-015021-pol2qm74	557	35	pyogenes	pyogene	NNS
cord-015021-pol2qm74	557	36	infections	infection	NNS
cord-015021-pol2qm74	557	37	in	in	IN
cord-015021-pol2qm74	557	38	humans	human	NNS
cord-015021-pol2qm74	557	39	.	.	.
cord-015021-pol2qm74	558	1	The	the	DT
cord-015021-pol2qm74	558	2	present	present	JJ
cord-015021-pol2qm74	558	3	study	study	NN
cord-015021-pol2qm74	558	4	was	be	VBD
cord-015021-pol2qm74	558	5	utidertakc	utidertakc	NNS
cord-015021-pol2qm74	558	6	~	~	NNP
cord-015021-pol2qm74	558	7	l	l	NNP
cord-015021-pol2qm74	558	8	to	to	IN
cord-015021-pol2qm74	558	9	cvalu	cvalu	NNP
cord-015021-pol2qm74	559	1	~tlc	~tlc	VB
cord-015021-pol2qm74	559	2	the	the	DT
cord-015021-pol2qm74	559	3	effect	effect	NN
cord-015021-pol2qm74	559	4	of	of	IN
cord-015021-pol2qm74	559	5	soluble	soluble	JJ
cord-015021-pol2qm74	559	6	chemically	chemically	RB
cord-015021-pol2qm74	559	7	modified	modify	VBN
cord-015021-pol2qm74	559	8	giucan	giucan	NN
cord-015021-pol2qm74	559	9	during	during	IN
cord-015021-pol2qm74	559	10	septic	septic	JJ
cord-015021-pol2qm74	559	11	shock	shock	NN
cord-015021-pol2qm74	559	12	.	.	.
cord-015021-pol2qm74	560	1	Carboxylnethyl	Carboxylnethyl	NNP
cord-015021-pol2qm74	560	2	-	-	HYPH
cord-015021-pol2qm74	560	3	b	b	NN
cord-015021-pol2qm74	560	4	-	-	:
cord-015021-pol2qm74	560	5	i,3-glucan	i,3-glucan	NN
cord-015021-pol2qm74	561	1	(	(	-LRB-
cord-015021-pol2qm74	561	2	ram	ram	VB
cord-015021-pol2qm74	561	3	120000	120000	CD
cord-015021-pol2qm74	561	4	)	)	-RRB-
cord-015021-pol2qm74	561	5	was	be	VBD
cord-015021-pol2qm74	561	6	injected	inject	VBN
cord-015021-pol2qm74	561	7	twice	twice	RB
cord-015021-pol2qm74	561	8	48	48	CD
cord-015021-pol2qm74	561	9	and	and	CC
cord-015021-pol2qm74	561	10	24	24	CD
cord-015021-pol2qm74	561	11	h	h	NN
cord-015021-pol2qm74	561	12	before	before	IN
cord-015021-pol2qm74	561	13	the	the	DT
cord-015021-pol2qm74	561	14	shock	shock	NN
cord-015021-pol2qm74	561	15	i.v	i.v	NNP
cord-015021-pol2qm74	561	16	.	.	.
cord-015021-pol2qm74	562	1	in	in	IN
cord-015021-pol2qm74	562	2	a	a	DT
cord-015021-pol2qm74	562	3	dose	dose	NN
cord-015021-pol2qm74	562	4	of	of	IN
cord-015021-pol2qm74	562	5	50	50	CD
cord-015021-pol2qm74	562	6	ing	ing	NN
cord-015021-pol2qm74	562	7	/	/	SYM
cord-015021-pol2qm74	562	8	kg	kg	NN
cord-015021-pol2qm74	562	9	.	.	.
cord-015021-pol2qm74	563	1	Shock	shock	NN
cord-015021-pol2qm74	563	2	was	be	VBD
cord-015021-pol2qm74	563	3	induced	induce	VBN
cord-015021-pol2qm74	563	4	in	in	IN
cord-015021-pol2qm74	563	5	u~?esthetizcd	u~?esthetizcd	NNP
cord-015021-pol2qm74	563	6	(	(	-LRB-
cord-015021-pol2qm74	563	7	sodikm~.	sodikm~.	NNP
cord-015021-pol2qm74	563	8	l)mntobarbital	l)mntobarbital	CD
cord-015021-pol2qm74	563	9	)	)	-RRB-
cord-015021-pol2qm74	563	10	rats	rat	NNS
cord-015021-pol2qm74	563	11	by	by	IN
cord-015021-pol2qm74	563	12	i.v	i.v	NNP
cord-015021-pol2qm74	563	13	.	.	NNP
cord-015021-pol2qm74	563	14	injection	injection	NN
cord-015021-pol2qm74	563	15	of	of	IN
cord-015021-pol2qm74	563	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	563	17	of	of	IN
cord-015021-pol2qm74	563	18	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	563	19	colli	colli	NNP
cord-015021-pol2qm74	563	20	0127	0127	CD
cord-015021-pol2qm74	563	21	BS	BS	NNP
cord-015021-pol2qm74	563	22	,	,	,
cord-015021-pol2qm74	563	23	5	5	CD
cord-015021-pol2qm74	563	24	mg	mg	NNP
cord-015021-pol2qm74	563	25	/	/	SYM
cord-015021-pol2qm74	563	26	kg	kg	NN
cord-015021-pol2qm74	563	27	.	.	.
cord-015021-pol2qm74	564	1	AIIofCMG	AIIofCMG	NNP
cord-015021-pol2qm74	564	2	pretreated	pretreate	VBD
cord-015021-pol2qm74	564	3	ruts	rut	NNS
cord-015021-pol2qm74	564	4	survived	survive	VBD
cord-015021-pol2qm74	564	5	during	during	IN
cord-015021-pol2qm74	564	6	first	first	JJ
cord-015021-pol2qm74	564	7	24haher	24haher	CD
cord-015021-pol2qm74	564	8	¢ndotoxine	¢ndotoxine	NN
cord-015021-pol2qm74	564	9	,	,	,
cord-015021-pol2qm74	564	10	while	while	IN
cord-015021-pol2qm74	564	11	in	in	IN
cord-015021-pol2qm74	564	12	controi	controi	NNP
cord-015021-pol2qm74	564	13	shock	shock	NN
cord-015021-pol2qm74	564	14	group	group	NN
cord-015021-pol2qm74	564	15	the	the	DT
cord-015021-pol2qm74	564	16	lethality	lethality	NN
cord-015021-pol2qm74	564	17	was	be	VBD
cord-015021-pol2qm74	564	18	90	90	CD
cord-015021-pol2qm74	564	19	%	%	NN
cord-015021-pol2qm74	564	20	.	.	.
cord-015021-pol2qm74	565	1	The	the	DT
cord-015021-pol2qm74	565	2	concentration	concentration	NN
cord-015021-pol2qm74	565	3	of	of	IN
cord-015021-pol2qm74	565	4	~col)terin	~col)terin	NN
cord-015021-pol2qm74	565	5	in	in	IN
cord-015021-pol2qm74	565	6	serum	serum	NN
cord-015021-pol2qm74	565	7	was	be	VBD
cord-015021-pol2qm74	565	8	significantly	significantly	RB
cord-015021-pol2qm74	565	9	elevated	elevate	VBN
cord-015021-pol2qm74	565	10	24	24	CD
cord-015021-pol2qm74	565	11	hafterthc	hafterthc	NN
cord-015021-pol2qm74	565	12	second	second	NN
cord-015021-pol2qm74	565	13	CMGinjection	CMGinjection	NNP
cord-015021-pol2qm74	566	1	(	(	-LRB-
cord-015021-pol2qm74	566	2	appare	appare	NNP
cord-015021-pol2qm74	566	3	~	~	NFP
cord-015021-pol2qm74	566	4	tly	tly	RB
cord-015021-pol2qm74	566	5	80	80	CD
cord-015021-pol2qm74	566	6	%	%	NN
cord-015021-pol2qm74	566	7	if	if	IN
cord-015021-pol2qm74	566	8	compare	compare	VBP
cord-015021-pol2qm74	566	9	with	with	IN
cord-015021-pol2qm74	566	10	the	the	DT
cord-015021-pol2qm74	566	11	control	control	NN
cord-015021-pol2qm74	566	12	rats	rat	NNS
cord-015021-pol2qm74	566	13	)	)	-RRB-
cord-015021-pol2qm74	566	14	,	,	,
cord-015021-pol2qm74	566	15	but	but	CC
cord-015021-pol2qm74	566	16	didu't	didu't	NNS
cord-015021-pol2qm74	566	17	chartged	chartge	VBD
cord-015021-pol2qm74	566	18	60	60	CD
cord-015021-pol2qm74	566	19	rain	rain	NN
cord-015021-pol2qm74	566	20	and	and	CC
cord-015021-pol2qm74	566	21	1	1	CD
cord-015021-pol2qm74	566	22	S0	s0	NN
cord-015021-pol2qm74	566	23	rain	rain	NN
cord-015021-pol2qm74	566	24	after	after	IN
cord-015021-pol2qm74	566	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	566	26	injectJom	injectJom	VBN
cord-015021-pol2qm74	566	27	Cardiac	cardiac	JJ
cord-015021-pol2qm74	566	28	output	output	NN
cord-015021-pol2qm74	566	29	in	in	IN
cord-015021-pol2qm74	566	30	CMOgroup	CMOgroup	NNP
cord-015021-pol2qm74	566	31	was	be	VBD
cord-015021-pol2qm74	566	32	higher	high	JJR
cord-015021-pol2qm74	567	1	a	a	LS
cord-015021-pol2qm74	567	2	*	*	NFP
cord-015021-pol2qm74	567	3	the	the	DT
cord-015021-pol2qm74	567	4	i20	i20	NNP
cord-015021-pol2qm74	567	5	and	and	CC
cord-015021-pol2qm74	567	6	180	180	CD
cord-015021-pol2qm74	567	7	min	min	NN
cord-015021-pol2qm74	567	8	after	after	IN
cord-015021-pol2qm74	567	9	endotoxine	endotoxine	JJ
cord-015021-pol2qm74	567	10	onset	onset	NN
cord-015021-pol2qm74	567	11	(	(	-LRB-
cord-015021-pol2qm74	567	12	8I	8i	CD
cord-015021-pol2qm74	567	13	%	%	NN
cord-015021-pol2qm74	567	14	trod	tread	VBD
cord-015021-pol2qm74	567	15	72~	72~	CD
cord-015021-pol2qm74	567	16	,	,	,
cord-015021-pol2qm74	567	17	respectively	respectively	RB
cord-015021-pol2qm74	567	18	of	of	IN
cord-015021-pol2qm74	567	19	initial	initial	JJ
cord-015021-pol2qm74	567	20	level	level	NN
cord-015021-pol2qm74	567	21	)	)	-RRB-
cord-015021-pol2qm74	568	1	than	than	IN
cord-015021-pol2qm74	568	2	in	in	IN
cord-015021-pol2qm74	568	3	the	the	DT
cord-015021-pol2qm74	568	4	control	control	NN
cord-015021-pol2qm74	568	5	shock	shock	NN
cord-015021-pol2qm74	568	6	group	group	NN
cord-015021-pol2qm74	568	7	(	(	-LRB-
cord-015021-pol2qm74	568	8	64	64	CD
cord-015021-pol2qm74	568	9	%	%	NN
cord-015021-pol2qm74	568	10	and	and	CC
cord-015021-pol2qm74	568	11	52	52	CD
cord-015021-pol2qm74	568	12	%	%	NN
cord-015021-pol2qm74	568	13	at	at	IN
cord-015021-pol2qm74	568	14	the	the	DT
cord-015021-pol2qm74	568	15	same	same	JJ
cord-015021-pol2qm74	568	16	time	time	NN
cord-015021-pol2qm74	568	17	)	)	-RRB-
cord-015021-pol2qm74	568	18	.	.	.
cord-015021-pol2qm74	569	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	569	2	of	of	IN
cord-015021-pol2qm74	569	3	rals	ral	NNS
cord-015021-pol2qm74	569	4	with	with	IN
cord-015021-pol2qm74	569	5	soh	soh	NNP
cord-015021-pol2qm74	569	6	~	~	NFP
cord-015021-pol2qm74	569	7	ble	ble	NNP
cord-015021-pol2qm74	569	8	gIucan	gIucan	NNP
cord-015021-pol2qm74	569	9	w	w	NN
cord-015021-pol2qm74	569	10	~	~	NFP
cord-015021-pol2qm74	569	11	ts	ts	NNP
cord-015021-pol2qm74	569	12	associated	associate	VBN
cord-015021-pol2qm74	569	13	with	with	IN
cord-015021-pol2qm74	569	14	beneficial	beneficial	JJ
cord-015021-pol2qm74	569	15	effects	effect	NNS
cord-015021-pol2qm74	569	16	o~	o~	XX
cord-015021-pol2qm74	569	17	the	the	DT
cord-015021-pol2qm74	569	18	hepatic	hepatic	JJ
cord-015021-pol2qm74	569	19	c	c	NN
cord-015021-pol2qm74	569	20	~	~	NFP
cord-015021-pol2qm74	569	21	ergy	ergy	NNP
cord-015021-pol2qm74	570	1	$	$	$
cord-015021-pol2qm74	570	2	Ia[tlS	Ia[tlS	NNP
cord-015021-pol2qm74	570	3	after	after	IN
cord-015021-pol2qm74	570	4	3	3	CD
cord-015021-pol2qm74	570	5	h	h	NN
cord-015021-pol2qm74	570	6	after	after	IN
cord-015021-pol2qm74	570	7	challenge	challenge	NN
cord-015021-pol2qm74	570	8	of	of	IN
cord-015021-pol2qm74	570	9	endotoxiae	endotoxiae	NNP
cord-015021-pol2qm74	570	10	:	:	:
cord-015021-pol2qm74	570	11	the	the	DT
cord-015021-pol2qm74	570	12	tissue	tissue	NN
cord-015021-pol2qm74	570	13	level	level	NN
cord-015021-pol2qm74	570	14	of	of	IN
cord-015021-pol2qm74	570	15	lactale	lactale	NN
cord-015021-pol2qm74	570	16	was	be	VBD
cord-015021-pol2qm74	570	17	ahnost	ahnost	NN
cord-015021-pol2qm74	570	18	twice	twice	RB
cord-015021-pol2qm74	570	19	lower	low	JJR
cord-015021-pol2qm74	570	20	than	than	IN
cord-015021-pol2qm74	570	21	in	in	IN
cord-015021-pol2qm74	570	22	the	the	DT
cord-015021-pol2qm74	570	23	control	control	NN
cord-015021-pol2qm74	570	24	ruts	rut	NNS
cord-015021-pol2qm74	570	25	,	,	,
cord-015021-pol2qm74	570	26	me	-PRON-	PRP
cord-015021-pol2qm74	570	27	~	~	NFP
cord-015021-pol2qm74	570	28	mthne	mthne	NNP
cord-015021-pol2qm74	570	29	the	the	DT
cord-015021-pol2qm74	570	30	tissue	tissue	NN
cord-015021-pol2qm74	570	31	ATF	ATF	NNP
cord-015021-pol2qm74	570	32	in	in	IN
cord-015021-pol2qm74	570	33	CMG	CMG	NNP
cord-015021-pol2qm74	570	34	pretreated	pretreate	VBD
cord-015021-pol2qm74	570	35	group	group	NN
cord-015021-pol2qm74	570	36	was	be	VBD
cord-015021-pol2qm74	570	37	higher	high	JJR
cord-015021-pol2qm74	570	38	at	at	IN
cord-015021-pol2qm74	570	39	40	40	CD
cord-015021-pol2qm74	570	40	%	%	NN
cord-015021-pol2qm74	570	41	.	.	.
cord-015021-pol2qm74	571	1	Twice	twice	RB
cord-015021-pol2qm74	571	2	injected	inject	VBN
cord-015021-pol2qm74	571	3	macrophage	macrophage	NN
cord-015021-pol2qm74	571	4	stimuhttor	stimuhttor	NN
cord-015021-pol2qm74	571	5	soluble	soluble	JJ
cord-015021-pol2qm74	571	6	glucan	glucan	NN
cord-015021-pol2qm74	571	7	can	can	MD
cord-015021-pol2qm74	571	8	prevent	prevent	VB
cord-015021-pol2qm74	571	9	the	the	DT
cord-015021-pol2qm74	571	10	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	571	11	shock	shock	NN
cord-015021-pol2qm74	571	12	,	,	,
cord-015021-pol2qm74	571	13	and	and	CC
cord-015021-pol2qm74	571	14	extremely	extremely	RB
cord-015021-pol2qm74	571	15	ir	ir	NNP
cord-015021-pol2qm74	571	16	~	~	NFP
cord-015021-pol2qm74	571	17	creased	crease	VBN
cord-015021-pol2qm74	571	18	survival	survival	NN
cord-015021-pol2qm74	571	19	rate	rate	NN
cord-015021-pol2qm74	571	20	after	after	IN
cord-015021-pol2qm74	571	21	endotoxine	endotoxine	NNP
cord-015021-pol2qm74	571	22	injection	injection	NN
cord-015021-pol2qm74	571	23	.	.	.
cord-015021-pol2qm74	572	1	The	the	DT
cord-015021-pol2qm74	572	2	National	National	NNP
cord-015021-pol2qm74	572	3	Committee	Committee	NNP
cord-015021-pol2qm74	572	4	of	of	IN
cord-015021-pol2qm74	572	5	Surgical	Surgical	NNP
cord-015021-pol2qm74	572	6	Infections	Infections	NNPS
cord-015021-pol2qm74	572	7	of	of	IN
cord-015021-pol2qm74	572	8	the	the	DT
cord-015021-pol2qm74	572	9	Spanish	Spanish	NNP
cord-015021-pol2qm74	572	10	Association	Association	NNP
cord-015021-pol2qm74	572	11	of	of	IN
cord-015021-pol2qm74	572	12	Surgeons	Surgeons	NNPS
cord-015021-pol2qm74	572	13	have	have	VBP
cord-015021-pol2qm74	572	14	produced	produce	VBN
cord-015021-pol2qm74	572	15	a	a	DT
cord-015021-pol2qm74	572	16	computer	computer	NN
cord-015021-pol2qm74	572	17	program	program	NN
cord-015021-pol2qm74	572	18	for	for	IN
cord-015021-pol2qm74	572	19	the	the	DT
cord-015021-pol2qm74	572	20	collection	collection	NN
cord-015021-pol2qm74	572	21	and	and	CC
cord-015021-pol2qm74	572	22	analysis	analysis	NN
cord-015021-pol2qm74	572	23	of	of	IN
cord-015021-pol2qm74	572	24	information	information	NN
cord-015021-pol2qm74	572	25	on	on	IN
cord-015021-pol2qm74	572	26	surgical	surgical	JJ
cord-015021-pol2qm74	572	27	infections	infection	NNS
cord-015021-pol2qm74	572	28	.	.	.
cord-015021-pol2qm74	573	1	The	the	DT
cord-015021-pol2qm74	573	2	program	program	NN
cord-015021-pol2qm74	573	3	is	be	VBZ
cord-015021-pol2qm74	573	4	suitable	suitable	JJ
cord-015021-pol2qm74	573	5	for	for	IN
cord-015021-pol2qm74	573	6	IBM	IBM	NNP
cord-015021-pol2qm74	573	7	compatible	compatible	JJ
cord-015021-pol2qm74	573	8	hard	hard	JJ
cord-015021-pol2qm74	573	9	disk	disk	NN
cord-015021-pol2qm74	573	10	personal	personal	JJ
cord-015021-pol2qm74	573	11	computers	computer	NNS
cord-015021-pol2qm74	573	12	and	and	CC
cord-015021-pol2qm74	573	13	works	work	VBZ
cord-015021-pol2qm74	573	14	through	through	IN
cord-015021-pol2qm74	573	15	the	the	DT
cord-015021-pol2qm74	573	16	MS	MS	NNP
cord-015021-pol2qm74	573	17	-	-	HYPH
cord-015021-pol2qm74	573	18	DOS	DOS	NNP
cord-015021-pol2qm74	573	19	system	system	NN
cord-015021-pol2qm74	573	20	.	.	.
cord-015021-pol2qm74	574	1	The	the	DT
cord-015021-pol2qm74	574	2	main	main	JJ
cord-015021-pol2qm74	574	3	menu	menu	NN
cord-015021-pol2qm74	574	4	is	be	VBZ
cord-015021-pol2qm74	574	5	called	call	VBN
cord-015021-pol2qm74	574	6	up	up	RP
cord-015021-pol2qm74	574	7	on	on	IN
cord-015021-pol2qm74	574	8	the	the	DT
cord-015021-pol2qm74	574	9	screen	screen	NN
cord-015021-pol2qm74	574	10	when	when	WRB
cord-015021-pol2qm74	574	11	the	the	DT
cord-015021-pol2qm74	574	12	operating	operating	NN
cord-015021-pol2qm74	574	13	disk	disk	NN
cord-015021-pol2qm74	574	14	has	have	VBZ
cord-015021-pol2qm74	574	15	been	be	VBN
cord-015021-pol2qm74	574	16	installed	instal	VBN
cord-015021-pol2qm74	574	17	;	;	:
cord-015021-pol2qm74	574	18	it	-PRON-	PRP
cord-015021-pol2qm74	574	19	reads	read	VBZ
cord-015021-pol2qm74	574	20	as	as	IN
cord-015021-pol2qm74	574	21	follows	follow	VBZ
cord-015021-pol2qm74	574	22	:	:	:
cord-015021-pol2qm74	575	1	I.	I.	NNP
cord-015021-pol2qm74	575	2	New	New	NNP
cord-015021-pol2qm74	575	3	record	record	NN
cord-015021-pol2qm74	575	4	;	;	:
cord-015021-pol2qm74	575	5	2	2	CD
cord-015021-pol2qm74	575	6	.	.	.
cord-015021-pol2qm74	576	1	Modify	modify	VB
cord-015021-pol2qm74	576	2	records	record	NNS
cord-015021-pol2qm74	576	3	;	;	:
cord-015021-pol2qm74	576	4	3	3	CD
cord-015021-pol2qm74	576	5	.	.	.
cord-015021-pol2qm74	577	1	Erase	erase	VB
cord-015021-pol2qm74	577	2	records	record	NNS
cord-015021-pol2qm74	577	3	;	;	:
cord-015021-pol2qm74	577	4	4	4	CD
cord-015021-pol2qm74	577	5	.	.	.
cord-015021-pol2qm74	578	1	Searches	search	NNS
cord-015021-pol2qm74	578	2	;	;	:
cord-015021-pol2qm74	578	3	5	5	CD
cord-015021-pol2qm74	578	4	.	.	.
cord-015021-pol2qm74	579	1	Reports	report	NNS
cord-015021-pol2qm74	579	2	;	;	:
cord-015021-pol2qm74	579	3	6	6	CD
cord-015021-pol2qm74	579	4	.	.	.
cord-015021-pol2qm74	580	1	Configure	configure	VB
cord-015021-pol2qm74	580	2	;	;	:
cord-015021-pol2qm74	580	3	O.	O.	NNP
cord-015021-pol2qm74	580	4	Ouit	Ouit	NNP
cord-015021-pol2qm74	580	5	.	.	.
cord-015021-pol2qm74	581	1	If	if	IN
cord-015021-pol2qm74	581	2	you	-PRON-	PRP
cord-015021-pol2qm74	581	3	ask	ask	VBP
cord-015021-pol2qm74	581	4	fdr	fdr	NNP
cord-015021-pol2qm74	581	5	a	a	DT
cord-015021-pol2qm74	581	6	new	new	JJ
cord-015021-pol2qm74	581	7	record	record	NN
cord-015021-pol2qm74	581	8	the	the	DT
cord-015021-pol2qm74	581	9	screen	screen	NN
cord-015021-pol2qm74	581	10	will	will	MD
cord-015021-pol2qm74	581	11	prompt	prompt	VB
cord-015021-pol2qm74	581	12	you	-PRON-	PRP
cord-015021-pol2qm74	581	13	to	to	TO
cord-015021-pol2qm74	581	14	enter	enter	VB
cord-015021-pol2qm74	581	15	the	the	DT
cord-015021-pol2qm74	581	16	number	number	NN
cord-015021-pol2qm74	581	17	of	of	IN
cord-015021-pol2qm74	581	18	case	case	NN
cord-015021-pol2qm74	581	19	,	,	,
cord-015021-pol2qm74	581	20	record	record	NN
cord-015021-pol2qm74	581	21	number	number	NN
cord-015021-pol2qm74	581	22	,	,	,
cord-015021-pol2qm74	581	23	hospital	hospital	NN
cord-015021-pol2qm74	581	24	,	,	,
cord-015021-pol2qm74	581	25	age	age	NN
cord-015021-pol2qm74	581	26	and	and	CC
cord-015021-pol2qm74	581	27	sex	sex	NN
cord-015021-pol2qm74	581	28	.	.	.
cord-015021-pol2qm74	582	1	The	the	DT
cord-015021-pol2qm74	582	2	next	next	JJ
cord-015021-pol2qm74	582	3	screen	screen	NN
cord-015021-pol2qm74	582	4	will	will	MD
cord-015021-pol2qm74	582	5	come	come	VB
cord-015021-pol2qm74	582	6	up	up	RP
cord-015021-pol2qm74	582	7	and	and	CC
cord-015021-pol2qm74	582	8	the	the	DT
cord-015021-pol2qm74	582	9	words	word	NNS
cord-015021-pol2qm74	582	10	"	"	``
cord-015021-pol2qm74	582	11	Topographic	topographic	JJ
cord-015021-pol2qm74	582	12	diagnosis	diagnosis	NN
cord-015021-pol2qm74	582	13	"	"	''
cord-015021-pol2qm74	582	14	will	will	MD
cord-015021-pol2qm74	582	15	flash	flash	VB
cord-015021-pol2qm74	582	16	.	.	.
cord-015021-pol2qm74	583	1	A	a	DT
cord-015021-pol2qm74	583	2	menu	menu	NN
cord-015021-pol2qm74	583	3	of	of	IN
cord-015021-pol2qm74	583	4	34	34	CD
cord-015021-pol2qm74	583	5	areas	area	NNS
cord-015021-pol2qm74	583	6	or	or	CC
cord-015021-pol2qm74	583	7	organs	organ	NNS
cord-015021-pol2qm74	583	8	will	will	MD
cord-015021-pol2qm74	583	9	be	be	VB
cord-015021-pol2qm74	583	10	displayed	display	VBN
cord-015021-pol2qm74	583	11	.	.	.
cord-015021-pol2qm74	584	1	Then	then	RB
cord-015021-pol2qm74	584	2	,	,	,
cord-015021-pol2qm74	584	3	the	the	DT
cord-015021-pol2qm74	584	4	words	word	NNS
cord-015021-pol2qm74	584	5	"	"	``
cord-015021-pol2qm74	584	6	Type	type	NN
cord-015021-pol2qm74	584	7	of	of	IN
cord-015021-pol2qm74	584	8	pathology	pathology	NN
cord-015021-pol2qm74	584	9	"	"	''
cord-015021-pol2qm74	584	10	(	(	-LRB-
cord-015021-pol2qm74	584	11	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	584	12	,	,	,
cord-015021-pol2qm74	584	13	neoplastic	neoplastic	JJ
cord-015021-pol2qm74	584	14	,	,	,
cord-015021-pol2qm74	584	15	traumatic	traumatic	JJ
cord-015021-pol2qm74	584	16	and	and	CC
cord-015021-pol2qm74	584	17	other	other	JJ
cord-015021-pol2qm74	584	18	)	)	-RRB-
cord-015021-pol2qm74	584	19	.	.	.
cord-015021-pol2qm74	585	1	Days	day	NNS
cord-015021-pol2qm74	585	2	of	of	IN
cord-015021-pol2qm74	585	3	postoperative	postoperative	JJ
cord-015021-pol2qm74	585	4	period	period	NN
cord-015021-pol2qm74	585	5	.	.	.
cord-015021-pol2qm74	586	1	Type	type	NN
cord-015021-pol2qm74	586	2	of	of	IN
cord-015021-pol2qm74	586	3	surgery	surgery	NN
cord-015021-pol2qm74	586	4	(	(	-LRB-
cord-015021-pol2qm74	586	5	programmed	program	VBN
cord-015021-pol2qm74	586	6	and	and	CC
cord-015021-pol2qm74	586	7	emergency	emergency	NN
cord-015021-pol2qm74	586	8	)	)	-RRB-
cord-015021-pol2qm74	586	9	.	.	.
cord-015021-pol2qm74	587	1	Type	type	NN
cord-015021-pol2qm74	587	2	of	of	IN
cord-015021-pol2qm74	587	3	operation	operation	NN
cord-015021-pol2qm74	587	4	(	(	-LRB-
cord-015021-pol2qm74	587	5	clean	clean	JJ
cord-015021-pol2qm74	587	6	,	,	,
cord-015021-pol2qm74	587	7	clean	clean	JJ
cord-015021-pol2qm74	587	8	contaminated	contaminate	VBN
cord-015021-pol2qm74	587	9	,	,	,
cord-015021-pol2qm74	587	10	contaminated	contaminated	JJ
cord-015021-pol2qm74	587	11	and	and	CC
cord-015021-pol2qm74	587	12	dirty	dirty	JJ
cord-015021-pol2qm74	587	13	)	)	-RRB-
cord-015021-pol2qm74	587	14	.	.	.
cord-015021-pol2qm74	588	1	Duration	duration	NN
cord-015021-pol2qm74	588	2	of	of	IN
cord-015021-pol2qm74	588	3	surgery	surgery	NN
cord-015021-pol2qm74	588	4	.	.	.
cord-015021-pol2qm74	589	1	This	this	DT
cord-015021-pol2qm74	589	2	is	be	VBZ
cord-015021-pol2qm74	589	3	followed	follow	VBN
cord-015021-pol2qm74	589	4	by	by	IN
cord-015021-pol2qm74	589	5	"	"	``
cord-015021-pol2qm74	589	6	Order	order	NN
cord-015021-pol2qm74	589	7	of	of	IN
cord-015021-pol2qm74	589	8	operation	operation	NN
cord-015021-pol2qm74	589	9	"	"	''
cord-015021-pol2qm74	589	10	and	and	CC
cord-015021-pol2qm74	589	11	the	the	DT
cord-015021-pol2qm74	589	12	"	"	``
cord-015021-pol2qm74	589	13	Type	type	NN
cord-015021-pol2qm74	589	14	of	of	IN
cord-015021-pol2qm74	589	15	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	589	16	(	(	-LRB-
cord-015021-pol2qm74	589	17	general	general	JJ
cord-015021-pol2qm74	589	18	,	,	,
cord-015021-pol2qm74	589	19	regional	regional	JJ
cord-015021-pol2qm74	589	20	or	or	CC
cord-015021-pol2qm74	589	21	local	local	JJ
cord-015021-pol2qm74	589	22	)	)	-RRB-
cord-015021-pol2qm74	589	23	.	.	.
cord-015021-pol2qm74	590	1	You	-PRON-	PRP
cord-015021-pol2qm74	590	2	are	be	VBP
cord-015021-pol2qm74	590	3	then	then	RB
cord-015021-pol2qm74	590	4	required	require	VBN
cord-015021-pol2qm74	590	5	to	to	TO
cord-015021-pol2qm74	590	6	supply	supply	VB
cord-015021-pol2qm74	590	7	the	the	DT
cord-015021-pol2qm74	590	8	"	"	``
cord-015021-pol2qm74	590	9	Diagnostic	diagnostic	JJ
cord-015021-pol2qm74	590	10	code	code	NN
cord-015021-pol2qm74	590	11	of	of	IN
cord-015021-pol2qm74	590	12	WHO	who	WP
cord-015021-pol2qm74	590	13	"	"	''
cord-015021-pol2qm74	590	14	(	(	-LRB-
cord-015021-pol2qm74	590	15	ICD9	ICD9	NNP
cord-015021-pol2qm74	590	16	)	)	-RRB-
cord-015021-pol2qm74	590	17	and	and	CC
cord-015021-pol2qm74	590	18	the	the	DT
cord-015021-pol2qm74	590	19	"	"	``
cord-015021-pol2qm74	590	20	Procedure	procedure	NN
cord-015021-pol2qm74	590	21	code	code	NN
cord-015021-pol2qm74	590	22	of	of	IN
cord-015021-pol2qm74	590	23	WHO	WHO	NNP
cord-015021-pol2qm74	590	24	.	.	.
cord-015021-pol2qm74	591	1	Analytic	analytic	JJ
cord-015021-pol2qm74	591	2	and	and	CC
cord-015021-pol2qm74	591	3	concurrent	concurrent	JJ
cord-015021-pol2qm74	591	4	illnesses	illness	NNS
cord-015021-pol2qm74	591	5	(	(	-LRB-
cord-015021-pol2qm74	591	6	total	total	JJ
cord-015021-pol2qm74	591	7	proteins	protein	NNS
cord-015021-pol2qm74	591	8	,	,	,
cord-015021-pol2qm74	591	9	albumin	albumin	NN
cord-015021-pol2qm74	591	10	,	,	,
cord-015021-pol2qm74	591	11	haemoglobin	haemoglobin	NN
cord-015021-pol2qm74	591	12	,	,	,
cord-015021-pol2qm74	591	13	haematocrit	haematocrit	NNP
cord-015021-pol2qm74	591	14	,	,	,
cord-015021-pol2qm74	591	15	leucocytes	leucocytes	NNP
cord-015021-pol2qm74	591	16	,	,	,
cord-015021-pol2qm74	591	17	red	red	JJ
cord-015021-pol2qm74	591	18	corpuscles	corpuscle	NNS
cord-015021-pol2qm74	591	19	,	,	,
cord-015021-pol2qm74	591	20	glucose	glucose	NN
cord-015021-pol2qm74	591	21	and	and	CC
cord-015021-pol2qm74	591	22	bilirubin	bilirubin	NN
cord-015021-pol2qm74	591	23	)	)	-RRB-
cord-015021-pol2qm74	591	24	.	.	.
cord-015021-pol2qm74	592	1	The	the	DT
cord-015021-pol2qm74	592	2	next	next	JJ
cord-015021-pol2qm74	592	3	screen	screen	NN
cord-015021-pol2qm74	592	4	asks	ask	VBZ
cord-015021-pol2qm74	592	5	for	for	IN
cord-015021-pol2qm74	592	6	"	"	``
cord-015021-pol2qm74	592	7	Risk	risk	NN
cord-015021-pol2qm74	592	8	factors	factor	NNS
cord-015021-pol2qm74	592	9	"	"	''
cord-015021-pol2qm74	592	10	(	(	-LRB-
cord-015021-pol2qm74	592	11	obesity	obesity	NN
cord-015021-pol2qm74	592	12	,	,	,
cord-015021-pol2qm74	592	13	uraemia	uraemia	NN
cord-015021-pol2qm74	592	14	,	,	,
cord-015021-pol2qm74	592	15	neoplasia	neoplasia	NN
cord-015021-pol2qm74	592	16	,	,	,
cord-015021-pol2qm74	592	17	malnutrition	malnutrition	NN
cord-015021-pol2qm74	592	18	,	,	,
cord-015021-pol2qm74	592	19	urinary	urinary	JJ
cord-015021-pol2qm74	592	20	catheter	catheter	NN
cord-015021-pol2qm74	592	21	,	,	,
cord-015021-pol2qm74	592	22	distant	distant	JJ
cord-015021-pol2qm74	592	23	infection	infection	NN
cord-015021-pol2qm74	592	24	,	,	,
cord-015021-pol2qm74	592	25	artificial	artificial	JJ
cord-015021-pol2qm74	592	26	valve	valve	NN
cord-015021-pol2qm74	592	27	,	,	,
cord-015021-pol2qm74	592	28	immunosuppressive	immunosuppressive	JJ
cord-015021-pol2qm74	592	29	drugs	drug	NNS
cord-015021-pol2qm74	592	30	,	,	,
cord-015021-pol2qm74	592	31	over	over	IN
cord-015021-pol2qm74	592	32	65	65	CD
cord-015021-pol2qm74	592	33	years	year	NNS
cord-015021-pol2qm74	592	34	and	and	CC
cord-015021-pol2qm74	592	35	anergy	anergy	NNP
cord-015021-pol2qm74	592	36	.	.	.
cord-015021-pol2qm74	593	1	This	this	DT
cord-015021-pol2qm74	593	2	is	be	VBZ
cord-015021-pol2qm74	593	3	followed	follow	VBN
cord-015021-pol2qm74	593	4	by	by	IN
cord-015021-pol2qm74	593	5	a	a	DT
cord-015021-pol2qm74	593	6	screen	screen	NN
cord-015021-pol2qm74	593	7	headed	head	VBN
cord-015021-pol2qm74	593	8	"	"	``
cord-015021-pol2qm74	593	9	Postoperative	postoperative	JJ
cord-015021-pol2qm74	593	10	complications	complication	NNS
cord-015021-pol2qm74	593	11	"	"	''
cord-015021-pol2qm74	593	12	.	.	.
cord-015021-pol2qm74	594	1	"	"	``
cord-015021-pol2qm74	594	2	Evolution	evolution	NN
cord-015021-pol2qm74	594	3	"	"	''
cord-015021-pol2qm74	594	4	(	(	-LRB-
cord-015021-pol2qm74	594	5	the	the	DT
cord-015021-pol2qm74	594	6	questions	question	NNS
cord-015021-pol2qm74	594	7	asked	ask	VBN
cord-015021-pol2qm74	594	8	are	be	VBP
cord-015021-pol2qm74	594	9	drainage	drainage	NN
cord-015021-pol2qm74	594	10	,	,	,
cord-015021-pol2qm74	594	11	systemic	systemic	JJ
cord-015021-pol2qm74	594	12	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	594	13	,	,	,
cord-015021-pol2qm74	594	14	and	and	CC
cord-015021-pol2qm74	594	15	on	on	IN
cord-015021-pol2qm74	594	16	each	each	DT
cord-015021-pol2qm74	594	17	ocasion	ocasion	NN
cord-015021-pol2qm74	594	18	a	a	DT
cord-015021-pol2qm74	594	19	choice	choice	NN
cord-015021-pol2qm74	594	20	of	of	IN
cord-015021-pol2qm74	594	21	31	31	CD
cord-015021-pol2qm74	594	22	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	594	23	is	be	VBZ
cord-015021-pol2qm74	594	24	displayed	display	VBN
cord-015021-pol2qm74	594	25	)	)	-RRB-
cord-015021-pol2qm74	594	26	,	,	,
cord-015021-pol2qm74	594	27	local	local	JJ
cord-015021-pol2qm74	594	28	antiseptics	antiseptic	NNS
cord-015021-pol2qm74	594	29	,	,	,
cord-015021-pol2qm74	594	30	reoperation	reoperation	NN
cord-015021-pol2qm74	594	31	,	,	,
cord-015021-pol2qm74	594	32	etc	etc	FW
cord-015021-pol2qm74	594	33	.	.	.
cord-015021-pol2qm74	595	1	Under	under	IN
cord-015021-pol2qm74	595	2	"	"	``
cord-015021-pol2qm74	595	3	Microhiology	Microhiology	NNP
cord-015021-pol2qm74	595	4	"	"	''
cord-015021-pol2qm74	595	5	is	be	VBZ
cord-015021-pol2qm74	595	6	a	a	DT
cord-015021-pol2qm74	595	7	choice	choice	NN
cord-015021-pol2qm74	595	8	of	of	IN
cord-015021-pol2qm74	595	9	37	37	CD
cord-015021-pol2qm74	595	10	organisms	organism	NNS
cord-015021-pol2qm74	595	11	and	and	CC
cord-015021-pol2qm74	595	12	the	the	DT
cord-015021-pol2qm74	595	13	chance	chance	NN
cord-015021-pol2qm74	595	14	of	of	IN
cord-015021-pol2qm74	595	15	identifyin	identifyin	NNP
cord-015021-pol2qm74	595	16	3	3	CD
cord-015021-pol2qm74	595	17	organisms	organism	NNS
cord-015021-pol2qm74	595	18	.	.	.
cord-015021-pol2qm74	596	1	Finally	finally	RB
cord-015021-pol2qm74	596	2	,	,	,
cord-015021-pol2qm74	596	3	"	"	``
cord-015021-pol2qm74	596	4	Sepsis	sepsis	NN
cord-015021-pol2qm74	596	5	score	score	NN
cord-015021-pol2qm74	596	6	"	"	''
cord-015021-pol2qm74	596	7	.	.	.
cord-015021-pol2qm74	597	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	597	2	recent	recent	JJ
cord-015021-pol2qm74	597	3	work	work	NN
cord-015021-pol2qm74	597	4	had	have	VBD
cord-015021-pol2qm74	597	5	shown	show	VBN
cord-015021-pol2qm74	597	6	that	that	IN
cord-015021-pol2qm74	597	7	RenShen	RenShen	NNP
cord-015021-pol2qm74	597	8	-	-	HYPH
cord-015021-pol2qm74	597	9	Fuzi	Fuzi	NNP
cord-015021-pol2qm74	597	10	-	-	HYPH
cord-015021-pol2qm74	597	11	ChaiHu	ChaiHu	NNS
cord-015021-pol2qm74	597	12	mixture	mixture	NN
cord-015021-pol2qm74	597	13	could	could	MD
cord-015021-pol2qm74	597	14	increase	increase	VB
cord-015021-pol2qm74	597	15	the	the	DT
cord-015021-pol2qm74	597	16	survival	survival	NN
cord-015021-pol2qm74	597	17	rate	rate	NN
cord-015021-pol2qm74	597	18	in	in	IN
cord-015021-pol2qm74	597	19	experimented	experiment	VBN
cord-015021-pol2qm74	597	20	study	study	NN
cord-015021-pol2qm74	597	21	.	.	.
cord-015021-pol2qm74	598	1	The	the	DT
cord-015021-pol2qm74	598	2	purpose	purpose	NN
cord-015021-pol2qm74	598	3	of	of	IN
cord-015021-pol2qm74	598	4	this	this	DT
cord-015021-pol2qm74	598	5	study	study	NN
cord-015021-pol2qm74	598	6	was	be	VBD
cord-015021-pol2qm74	598	7	to	to	TO
cord-015021-pol2qm74	598	8	determine	determine	VB
cord-015021-pol2qm74	598	9	the	the	DT
cord-015021-pol2qm74	598	10	effect	effect	NN
cord-015021-pol2qm74	598	11	of	of	IN
cord-015021-pol2qm74	598	12	combined	combined	JJ
cord-015021-pol2qm74	598	13	administration	administration	NN
cord-015021-pol2qm74	598	14	of	of	IN
cord-015021-pol2qm74	598	15	RenShen	RenShen	NNP
cord-015021-pol2qm74	598	16	-	-	HYPH
cord-015021-pol2qm74	598	17	Fuzi	Fuzi	NNP
cord-015021-pol2qm74	598	18	-	-	HYPH
cord-015021-pol2qm74	598	19	ChaiHu	ChaiHu	NNS
cord-015021-pol2qm74	598	20	mixtuer	mixtuer	NNP
cord-015021-pol2qm74	598	21	and	and	CC
cord-015021-pol2qm74	598	22	Antibitics	Antibitics	NNP
cord-015021-pol2qm74	598	23	(	(	-LRB-
cord-015021-pol2qm74	598	24	SA	SA	NNP
cord-015021-pol2qm74	598	25	)	)	-RRB-
cord-015021-pol2qm74	598	26	in	in	IN
cord-015021-pol2qm74	598	27	patients	patient	NNS
cord-015021-pol2qm74	598	28	with	with	IN
cord-015021-pol2qm74	598	29	septic	septic	JJ
cord-015021-pol2qm74	598	30	shock	shock	NN
cord-015021-pol2qm74	598	31	.	.	.
cord-015021-pol2qm74	599	1	The	the	DT
cord-015021-pol2qm74	599	2	result	result	NN
cord-015021-pol2qm74	599	3	showed	show	VBD
cord-015021-pol2qm74	599	4	that	that	IN
cord-015021-pol2qm74	599	5	,	,	,
cord-015021-pol2qm74	599	6	in	in	IN
cord-015021-pol2qm74	599	7	SA	SA	NNP
cord-015021-pol2qm74	599	8	group	group	NN
cord-015021-pol2qm74	599	9	(	(	-LRB-
cord-015021-pol2qm74	599	10	40	40	CD
cord-015021-pol2qm74	599	11	cases	case	NNS
cord-015021-pol2qm74	599	12	)	)	-RRB-
cord-015021-pol2qm74	599	13	,	,	,
cord-015021-pol2qm74	599	14	the	the	DT
cord-015021-pol2qm74	599	15	total	total	JJ
cord-015021-pol2qm74	599	16	effective	effective	JJ
cord-015021-pol2qm74	599	17	rate	rate	NN
cord-015021-pol2qm74	599	18	was	be	VBD
cord-015021-pol2qm74	599	19	87,5	87,5	CD
cord-015021-pol2qm74	599	20	%	%	NN
cord-015021-pol2qm74	599	21	,	,	,
cord-015021-pol2qm74	599	22	in	in	IN
cord-015021-pol2qm74	599	23	the	the	DT
cord-015021-pol2qm74	599	24	contral	contral	JJ
cord-015021-pol2qm74	599	25	group	group	NN
cord-015021-pol2qm74	599	26	(	(	-LRB-
cord-015021-pol2qm74	599	27	Combined	combine	VBN
cord-015021-pol2qm74	599	28	administration	administration	NN
cord-015021-pol2qm74	599	29	of	of	IN
cord-015021-pol2qm74	599	30	gentamycin	gentamycin	NNP
cord-015021-pol2qm74	599	31	and	and	CC
cord-015021-pol2qm74	599	32	dexamethasone	dexamethasone	NN
cord-015021-pol2qm74	599	33	,	,	,
cord-015021-pol2qm74	599	34	25	25	CD
cord-015021-pol2qm74	599	35	cases	case	NNS
cord-015021-pol2qm74	599	36	)	)	-RRB-
cord-015021-pol2qm74	599	37	the	the	DT
cord-015021-pol2qm74	599	38	total	total	JJ
cord-015021-pol2qm74	599	39	effective	effective	JJ
cord-015021-pol2qm74	599	40	rate	rate	NN
cord-015021-pol2qm74	599	41	was	be	VBD
cord-015021-pol2qm74	599	42	84	84	CD
cord-015021-pol2qm74	599	43	%	%	NN
cord-015021-pol2qm74	599	44	.	.	.
cord-015021-pol2qm74	600	1	However	however	RB
cord-015021-pol2qm74	600	2	the	the	DT
cord-015021-pol2qm74	600	3	obviously	obviously	RB
cord-015021-pol2qm74	600	4	effective	effective	JJ
cord-015021-pol2qm74	600	5	rate	rate	NN
cord-015021-pol2qm74	600	6	in	in	IN
cord-015021-pol2qm74	600	7	SA	SA	NNP
cord-015021-pol2qm74	600	8	group	group	NN
cord-015021-pol2qm74	600	9	70	70	CD
cord-015021-pol2qm74	600	10	%	%	NN
cord-015021-pol2qm74	600	11	was	be	VBD
cord-015021-pol2qm74	600	12	significantly	significantly	RB
cord-015021-pol2qm74	600	13	higher	high	JJR
cord-015021-pol2qm74	600	14	than	than	IN
cord-015021-pol2qm74	600	15	in	in	IN
cord-015021-pol2qm74	600	16	contral	contral	JJ
cord-015021-pol2qm74	600	17	group	group	NN
cord-015021-pol2qm74	600	18	44	44	CD
cord-015021-pol2qm74	600	19	%	%	NN
cord-015021-pol2qm74	600	20	(	(	-LRB-
cord-015021-pol2qm74	600	21	P	p	NN
cord-015021-pol2qm74	600	22	<	<	XX
cord-015021-pol2qm74	600	23	O.OS	O.OS	NNP
cord-015021-pol2qm74	600	24	)	)	-RRB-
cord-015021-pol2qm74	600	25	.	.	.
cord-015021-pol2qm74	601	1	SA	SA	NNP
cord-015021-pol2qm74	601	2	group	group	NN
cord-015021-pol2qm74	601	3	appeared	appear	VBD
cord-015021-pol2qm74	601	4	to	to	TO
cord-015021-pol2qm74	601	5	be	be	VB
cord-015021-pol2qm74	601	6	more	more	RBR
cord-015021-pol2qm74	601	7	obvious	obvious	JJ
cord-015021-pol2qm74	601	8	than	than	IN
cord-015021-pol2qm74	601	9	the	the	DT
cord-015021-pol2qm74	601	10	contral	contral	NNP
cord-015021-pol2qm74	601	11	group	group	NN
cord-015021-pol2qm74	601	12	in	in	IN
cord-015021-pol2qm74	601	13	raising	raise	VBG
cord-015021-pol2qm74	601	14	arterial	arterial	JJ
cord-015021-pol2qm74	601	15	pressure	pressure	NN
cord-015021-pol2qm74	601	16	,	,	,
cord-015021-pol2qm74	601	17	recovering	recover	VBG
cord-015021-pol2qm74	601	18	consciousness	consciousness	NN
cord-015021-pol2qm74	601	19	and	and	CC
cord-015021-pol2qm74	601	20	pulse	pulse	NN
cord-015021-pol2qm74	601	21	,	,	,
cord-015021-pol2qm74	601	22	improving	improve	VBG
cord-015021-pol2qm74	601	23	cold	cold	JJ
cord-015021-pol2qm74	601	24	lilmbs	lilmb	NNS
cord-015021-pol2qm74	601	25	and	and	CC
cord-015021-pol2qm74	601	26	reducing	reduce	VBG
cord-015021-pol2qm74	601	27	fever	fever	NN
cord-015021-pol2qm74	601	28	(	(	-LRB-
cord-015021-pol2qm74	601	29	P	p	NN
cord-015021-pol2qm74	601	30	<	<	XX
cord-015021-pol2qm74	601	31	O.O5	O.O5	NNP
cord-015021-pol2qm74	601	32	)	)	-RRB-
cord-015021-pol2qm74	601	33	.	.	.
cord-015021-pol2qm74	602	1	It	-PRON-	PRP
cord-015021-pol2qm74	602	2	was	be	VBD
cord-015021-pol2qm74	602	3	found	find	VBN
cord-015021-pol2qm74	602	4	that	that	IN
cord-015021-pol2qm74	602	5	SA	SA	NNP
cord-015021-pol2qm74	602	6	could	could	MD
cord-015021-pol2qm74	602	7	inhibit	inhibit	VB
cord-015021-pol2qm74	602	8	the	the	DT
cord-015021-pol2qm74	602	9	pathogeneses	pathogenese	NNS
cord-015021-pol2qm74	602	10	changes	change	NNS
cord-015021-pol2qm74	602	11	of	of	IN
cord-015021-pol2qm74	602	12	septic	septic	JJ
cord-015021-pol2qm74	602	13	shock	shock	NN
cord-015021-pol2qm74	602	14	such	such	JJ
cord-015021-pol2qm74	602	15	as	as	IN
cord-015021-pol2qm74	602	16	the	the	DT
cord-015021-pol2qm74	602	17	decreases	decrease	NNS
cord-015021-pol2qm74	602	18	of	of	IN
cord-015021-pol2qm74	602	19	superotide	superotide	NNP
cord-015021-pol2qm74	602	20	dismutase	dismutase	NN
cord-015021-pol2qm74	602	21	(	(	-LRB-
cord-015021-pol2qm74	602	22	SOD	SOD	NNP
cord-015021-pol2qm74	602	23	)	)	-RRB-
cord-015021-pol2qm74	602	24	and	and	CC
cord-015021-pol2qm74	602	25	glutathione	glutathione	NN
cord-015021-pol2qm74	602	26	peroxidase	peroxidase	NN
cord-015021-pol2qm74	602	27	(	(	-LRB-
cord-015021-pol2qm74	602	28	GSH	GSH	NNP
cord-015021-pol2qm74	602	29	-	-	HYPH
cord-015021-pol2qm74	602	30	PX	PX	NNP
cord-015021-pol2qm74	602	31	)	)	-RRB-
cord-015021-pol2qm74	602	32	in	in	IN
cord-015021-pol2qm74	602	33	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	602	34	and	and	CC
cord-015021-pol2qm74	602	35	the	the	DT
cord-015021-pol2qm74	602	36	increases	increase	NNS
cord-015021-pol2qm74	602	37	of	of	IN
cord-015021-pol2qm74	602	38	plasma	plasma	NN
cord-015021-pol2qm74	602	39	free	free	JJ
cord-015021-pol2qm74	602	40	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	602	41	(	(	-LRB-
cord-015021-pol2qm74	602	42	PHb	PHb	NNS
cord-015021-pol2qm74	602	43	)	)	-RRB-
cord-015021-pol2qm74	602	44	,	,	,
cord-015021-pol2qm74	602	45	plasma	plasma	NNP
cord-015021-pol2qm74	602	46	malondialdehyde	malondialdehyde	NNP
cord-015021-pol2qm74	602	47	(	(	-LRB-
cord-015021-pol2qm74	602	48	MDA	MDA	NNP
cord-015021-pol2qm74	602	49	)	)	-RRB-
cord-015021-pol2qm74	602	50	and	and	CC
cord-015021-pol2qm74	602	51	13-glucuronidase	13-glucuronidase	CD
cord-015021-pol2qm74	602	52	(	(	-LRB-
cord-015021-pol2qm74	602	53	13-GC	13-gc	CD
cord-015021-pol2qm74	602	54	)	)	-RRB-
cord-015021-pol2qm74	602	55	occured	occur	VBD
cord-015021-pol2qm74	602	56	in	in	IN
cord-015021-pol2qm74	602	57	septic	septic	JJ
cord-015021-pol2qm74	602	58	shock	shock	NN
cord-015021-pol2qm74	602	59	.	.	.
cord-015021-pol2qm74	603	1	SA	SA	NNP
cord-015021-pol2qm74	603	2	had	have	VBD
cord-015021-pol2qm74	603	3	stronger	strong	JJR
cord-015021-pol2qm74	603	4	effect	effect	NN
cord-015021-pol2qm74	603	5	than	than	IN
cord-015021-pol2qm74	603	6	GD	GD	NNP
cord-015021-pol2qm74	603	7	in	in	IN
cord-015021-pol2qm74	603	8	inhibiting	inhibit	VBG
cord-015021-pol2qm74	603	9	the	the	DT
cord-015021-pol2qm74	603	10	changes	change	NNS
cord-015021-pol2qm74	603	11	mentioned	mention	VBN
cord-015021-pol2qm74	603	12	above	above	RB
cord-015021-pol2qm74	603	13	.	.	.
cord-015021-pol2qm74	604	1	Hence	hence	RB
cord-015021-pol2qm74	604	2	,	,	,
cord-015021-pol2qm74	604	3	these	these	DT
cord-015021-pol2qm74	604	4	results	result	NNS
cord-015021-pol2qm74	604	5	suggest	suggest	VBP
cord-015021-pol2qm74	604	6	that	that	IN
cord-015021-pol2qm74	604	7	SA	SA	NNP
cord-015021-pol2qm74	604	8	has	have	VBZ
cord-015021-pol2qm74	604	9	beneficial	beneficial	JJ
cord-015021-pol2qm74	604	10	effect	effect	NN
cord-015021-pol2qm74	604	11	in	in	IN
cord-015021-pol2qm74	604	12	the	the	DT
cord-015021-pol2qm74	604	13	treatment	treatment	NN
cord-015021-pol2qm74	604	14	of	of	IN
cord-015021-pol2qm74	604	15	septic	septic	JJ
cord-015021-pol2qm74	604	16	shock	shock	NN
cord-015021-pol2qm74	604	17	.	.	.
cord-015021-pol2qm74	605	1	SA	SA	NNP
cord-015021-pol2qm74	605	2	could	could	MD
cord-015021-pol2qm74	605	3	diminish	diminish	VB
cord-015021-pol2qm74	605	4	the	the	DT
cord-015021-pol2qm74	605	5	decrease	decrease	NN
cord-015021-pol2qm74	605	6	of	of	IN
cord-015021-pol2qm74	605	7	the	the	DT
cord-015021-pol2qm74	605	8	antioxdase	antioxdase	NNP
cord-015021-pol2qm74	605	9	activities	activity	NNS
cord-015021-pol2qm74	605	10	and	and	CC
cord-015021-pol2qm74	605	11	inhibit	inhibit	VB
cord-015021-pol2qm74	605	12	lipid	lipid	NN
cord-015021-pol2qm74	605	13	peroxidization	peroxidization	NN
cord-015021-pol2qm74	605	14	and	and	CC
cord-015021-pol2qm74	605	15	stabilize	stabilize	VB
cord-015021-pol2qm74	605	16	cellmembrance	cellmembrance	NN
cord-015021-pol2qm74	605	17	.	.	.
cord-015021-pol2qm74	606	1	This	this	DT
cord-015021-pol2qm74	606	2	may	may	MD
cord-015021-pol2qm74	606	3	be	be	VB
cord-015021-pol2qm74	606	4	one	one	CD
cord-015021-pol2qm74	606	5	of	of	IN
cord-015021-pol2qm74	606	6	the	the	DT
cord-015021-pol2qm74	606	7	principal	principal	JJ
cord-015021-pol2qm74	606	8	mechanisms	mechanism	NNS
cord-015021-pol2qm74	606	9	of	of	IN
cord-015021-pol2qm74	606	10	the	the	DT
cord-015021-pol2qm74	606	11	beneficial	beneficial	JJ
cord-015021-pol2qm74	606	12	effect	effect	NN
cord-015021-pol2qm74	606	13	of	of	IN
cord-015021-pol2qm74	606	14	SA	SA	NNP
cord-015021-pol2qm74	606	15	in	in	IN
cord-015021-pol2qm74	606	16	the	the	DT
cord-015021-pol2qm74	606	17	treatment	treatment	NN
cord-015021-pol2qm74	606	18	of	of	IN
cord-015021-pol2qm74	606	19	septic	septic	JJ
cord-015021-pol2qm74	606	20	shock	shock	NN
cord-015021-pol2qm74	606	21	.	.	.
cord-015021-pol2qm74	607	1	Donna	Donna	NNP
cord-015021-pol2qm74	607	2	L.	L.	NNP
cord-015021-pol2qm74	607	3	Lehman	Lehman	NNP
cord-015021-pol2qm74	607	4	,	,	,
cord-015021-pol2qm74	607	5	Heather	Heather	NNP
cord-015021-pol2qm74	607	6	A.	A.	NNP
cord-015021-pol2qm74	607	7	Childers	Childers	NNP
cord-015021-pol2qm74	607	8	,	,	,
cord-015021-pol2qm74	607	9	Irshad	Irshad	NNP
cord-015021-pol2qm74	607	10	H.	H.	NNP
cord-015021-pol2qm74	607	11	Chaudry	Chaudry	NNP
cord-015021-pol2qm74	607	12	and	and	CC
cord-015021-pol2qm74	607	13	Alfred	Alfred	NNP
cord-015021-pol2qm74	607	14	Ayala	Ayala	NNP
cord-015021-pol2qm74	607	15	.	.	.
cord-015021-pol2qm74	608	1	The	the	DT
cord-015021-pol2qm74	608	2	thymus	thymus	NN
cord-015021-pol2qm74	608	3	is	be	VBZ
cord-015021-pol2qm74	608	4	thought	think	VBN
cord-015021-pol2qm74	608	5	to	to	TO
cord-015021-pol2qm74	608	6	be	be	VB
cord-015021-pol2qm74	608	7	a	a	DT
cord-015021-pol2qm74	608	8	privileged	privileged	JJ
cord-015021-pol2qm74	608	9	sight	sight	NN
cord-015021-pol2qm74	608	10	for	for	IN
cord-015021-pol2qm74	608	11	Tcell	Tcell	NNP
cord-015021-pol2qm74	608	12	generation	generation	NN
cord-015021-pol2qm74	608	13	.	.	.
cord-015021-pol2qm74	609	1	Here	here	RB
cord-015021-pol2qm74	609	2	the	the	DT
cord-015021-pol2qm74	609	3	T	t	NN
cord-015021-pol2qm74	609	4	-	-	HYPH
cord-015021-pol2qm74	609	5	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	609	6	are	be	VBP
cord-015021-pol2qm74	609	7	either	either	RB
cord-015021-pol2qm74	609	8	selected	select	VBN
cord-015021-pol2qm74	609	9	for	for	IN
cord-015021-pol2qm74	609	10	their	-PRON-	PRP$
cord-015021-pol2qm74	609	11	potential	potential	NN
cord-015021-pol2qm74	609	12	to	to	TO
cord-015021-pol2qm74	609	13	recognize	recognize	VB
cord-015021-pol2qm74	609	14	and	and	CC
cord-015021-pol2qm74	609	15	react	react	VB
cord-015021-pol2qm74	609	16	competently	competently	RB
cord-015021-pol2qm74	609	17	to	to	IN
cord-015021-pol2qm74	609	18	foreign	foreign	JJ
cord-015021-pol2qm74	609	19	antigens	antigen	NNS
cord-015021-pol2qm74	609	20	or	or	CC
cord-015021-pol2qm74	609	21	de	de	JJ
cord-015021-pol2qm74	609	22	-	-	VBN
cord-015021-pol2qm74	609	23	selected	select	VBN
cord-015021-pol2qm74	609	24	,	,	,
cord-015021-pol2qm74	609	25	due	due	IN
cord-015021-pol2qm74	609	26	to	to	IN
cord-015021-pol2qm74	609	27	their	-PRON-	PRP$
cord-015021-pol2qm74	609	28	potential	potential	NN
cord-015021-pol2qm74	609	29	to	to	TO
cord-015021-pol2qm74	609	30	react	react	VB
cord-015021-pol2qm74	609	31	to	to	IN
cord-015021-pol2qm74	609	32	auto	auto	NN
cord-015021-pol2qm74	609	33	-	-	HYPH
cord-015021-pol2qm74	609	34	antigens	antigen	NNS
cord-015021-pol2qm74	609	35	,	,	,
cord-015021-pol2qm74	609	36	de	de	NN
cord-015021-pol2qm74	609	37	-	-	VBN
cord-015021-pol2qm74	609	38	selected	select	VBN
cord-015021-pol2qm74	609	39	.	.	.
cord-015021-pol2qm74	610	1	Tcells	Tcells	NNP
cord-015021-pol2qm74	610	2	with	with	IN
cord-015021-pol2qm74	610	3	this	this	DT
cord-015021-pol2qm74	610	4	latter	latter	JJ
cord-015021-pol2qm74	610	5	capacity	capacity	NN
cord-015021-pol2qm74	610	6	are	be	VBP
cord-015021-pol2qm74	610	7	thought	think	VBN
cord-015021-pol2qm74	610	8	to	to	TO
cord-015021-pol2qm74	610	9	be	be	VB
cord-015021-pol2qm74	610	10	deselected	deselecte	VBN
cord-015021-pol2qm74	610	11	through	through	IN
cord-015021-pol2qm74	610	12	a	a	DT
cord-015021-pol2qm74	610	13	process	process	NN
cord-015021-pol2qm74	610	14	referred	refer	VBN
cord-015021-pol2qm74	610	15	to	to	IN
cord-015021-pol2qm74	610	16	as	as	IN
cord-015021-pol2qm74	610	17	programmed	program	VBN
cord-015021-pol2qm74	610	18	cell	cell	NN
cord-015021-pol2qm74	610	19	death	death	NN
cord-015021-pol2qm74	610	20	or	or	CC
cord-015021-pol2qm74	610	21	apoptosis	apoptosis	NN
cord-015021-pol2qm74	610	22	.	.	.
cord-015021-pol2qm74	611	1	While	while	IN
cord-015021-pol2qm74	611	2	it	-PRON-	PRP
cord-015021-pol2qm74	611	3	is	be	VBZ
cord-015021-pol2qm74	611	4	known	know	VBN
cord-015021-pol2qm74	611	5	that	that	IN
cord-015021-pol2qm74	611	6	thymic	thymic	JJ
cord-015021-pol2qm74	611	7	apoptosis	apoptosis	NN
cord-015021-pol2qm74	611	8	is	be	VBZ
cord-015021-pol2qm74	611	9	elevated	elevate	VBN
cord-015021-pol2qm74	611	10	by	by	IN
cord-015021-pol2qm74	611	11	a	a	DT
cord-015021-pol2qm74	611	12	variety	variety	NN
cord-015021-pol2qm74	611	13	of	of	IN
cord-015021-pol2qm74	611	14	stressers	stresser	NNS
cord-015021-pol2qm74	611	15	associated	associate	VBN
cord-015021-pol2qm74	611	16	with	with	IN
cord-015021-pol2qm74	611	17	infection	infection	NN
cord-015021-pol2qm74	611	18	and	and	CC
cord-015021-pol2qm74	611	19	inflammation	inflammation	NN
cord-015021-pol2qm74	611	20	,	,	,
cord-015021-pol2qm74	611	21	little	little	JJ
cord-015021-pol2qm74	611	22	or	or	CC
cord-015021-pol2qm74	611	23	no	no	DT
cord-015021-pol2qm74	611	24	information	information	NN
cord-015021-pol2qm74	611	25	is	be	VBZ
cord-015021-pol2qm74	611	26	available	available	JJ
cord-015021-pol2qm74	611	27	concerning	concern	VBG
cord-015021-pol2qm74	611	28	its	-PRON-	PRP$
cord-015021-pol2qm74	611	29	presence	presence	NN
cord-015021-pol2qm74	611	30	in	in	IN
cord-015021-pol2qm74	611	31	polymicrobial	polymicrobial	JJ
cord-015021-pol2qm74	611	32	sepsis	sepsis	NN
cord-015021-pol2qm74	611	33	.	.	.
cord-015021-pol2qm74	612	1	It	-PRON-	PRP
cord-015021-pol2qm74	612	2	was	be	VBD
cord-015021-pol2qm74	612	3	,	,	,
cord-015021-pol2qm74	612	4	therefore	therefore	RB
cord-015021-pol2qm74	612	5	,	,	,
cord-015021-pol2qm74	612	6	the	the	DT
cord-015021-pol2qm74	612	7	aim	aim	NN
cord-015021-pol2qm74	612	8	of	of	IN
cord-015021-pol2qm74	612	9	this	this	DT
cord-015021-pol2qm74	612	10	study	study	NN
cord-015021-pol2qm74	612	11	to	to	TO
cord-015021-pol2qm74	612	12	determine	determine	VB
cord-015021-pol2qm74	612	13	whether	whether	IN
cord-015021-pol2qm74	612	14	thymocytes	thymocyte	NNS
cord-015021-pol2qm74	612	15	exhibit	exhibit	NN
cord-015021-pol2qm74	612	16	increased	increase	VBN
cord-015021-pol2qm74	612	17	apoptosis	apoptosis	NN
cord-015021-pol2qm74	612	18	during	during	IN
cord-015021-pol2qm74	612	19	sepsis	sepsis	NN
cord-015021-pol2qm74	612	20	.	.	.
cord-015021-pol2qm74	613	1	To	to	TO
cord-015021-pol2qm74	613	2	assess	assess	VB
cord-015021-pol2qm74	613	3	this	this	DT
cord-015021-pol2qm74	613	4	,	,	,
cord-015021-pol2qm74	613	5	thymocytes	thymocyte	NNS
cord-015021-pol2qm74	613	6	were	be	VBD
cord-015021-pol2qm74	613	7	harvested	harvest	VBN
cord-015021-pol2qm74	613	8	from	from	IN
cord-015021-pol2qm74	613	9	C3H	c3h	JJ
cord-015021-pol2qm74	613	10	/	/	SYM
cord-015021-pol2qm74	613	11	HeN	hen	JJ
cord-015021-pol2qm74	613	12	mice	mouse	NNS
cord-015021-pol2qm74	613	13	at	at	IN
cord-015021-pol2qm74	613	14	i	i	PRP
cord-015021-pol2qm74	613	15	and	and	CC
cord-015021-pol2qm74	613	16	24	24	CD
cord-015021-pol2qm74	613	17	h	h	NN
cord-015021-pol2qm74	613	18	following	follow	VBG
cord-015021-pol2qm74	613	19	cecal	cecal	JJ
cord-015021-pol2qm74	613	20	ligation	ligation	NN
cord-015021-pol2qm74	613	21	and	and	CC
cord-015021-pol2qm74	613	22	puncture	puncture	NN
cord-015021-pol2qm74	613	23	(	(	-LRB-
cord-015021-pol2qm74	613	24	CLP	clp	NN
cord-015021-pol2qm74	613	25	;	;	:
cord-015021-pol2qm74	613	26	to	to	TO
cord-015021-pol2qm74	613	27	induce	induce	VB
cord-015021-pol2qm74	613	28	sepsis	sepsis	NN
cord-015021-pol2qm74	613	29	)	)	-RRB-
cord-015021-pol2qm74	613	30	or	or	CC
cord-015021-pol2qm74	613	31	Sham	Sham	NNP
cord-015021-pol2qm74	613	32	-	-	HYPH
cord-015021-pol2qm74	613	33	CLP	CLP	NNP
cord-015021-pol2qm74	613	34	(	(	-LRB-
cord-015021-pol2qm74	613	35	Sham	Sham	NNP
cord-015021-pol2qm74	613	36	)	)	-RRB-
cord-015021-pol2qm74	613	37	.	.	.
cord-015021-pol2qm74	614	1	Thymic	Thymic	NNP
cord-015021-pol2qm74	614	2	yields	yield	NNS
cord-015021-pol2qm74	614	3	were	be	VBD
cord-015021-pol2qm74	614	4	assessed	assess	VBN
cord-015021-pol2qm74	614	5	and	and	CC
cord-015021-pol2qm74	614	6	the	the	DT
cord-015021-pol2qm74	614	7	extent	extent	NN
cord-015021-pol2qm74	614	8	of	of	IN
cord-015021-pol2qm74	614	9	apetosis	apetosis	NN
cord-015021-pol2qm74	614	10	determined	determine	VBN
cord-015021-pol2qm74	614	11	by	by	IN
cord-015021-pol2qm74	614	12	staining	stain	VBG
cord-015021-pol2qm74	614	13	the	the	DT
cord-015021-pol2qm74	614	14	cells	cell	NNS
cord-015021-pol2qm74	614	15	with	with	IN
cord-015021-pol2qm74	614	16	propidium	propidium	NN
cord-015021-pol2qm74	614	17	iodide	iodide	NN
cord-015021-pol2qm74	614	18	(	(	-LRB-
cord-015021-pol2qm74	614	19	a	a	DT
cord-015021-pol2qm74	614	20	DNA	dna	NN
cord-015021-pol2qm74	614	21	intercalating	intercalating	NN
cord-015021-pol2qm74	614	22	dye	dye	NN
cord-015021-pol2qm74	614	23	)	)	-RRB-
cord-015021-pol2qm74	614	24	for	for	IN
cord-015021-pol2qm74	614	25	FACS	FACS	NNP
cord-015021-pol2qm74	614	26	analysis	analysis	NN
cord-015021-pol2qm74	614	27	or	or	CC
cord-015021-pol2qm74	614	28	by	by	IN
cord-015021-pol2qm74	614	29	examining	examine	VBG
cord-015021-pol2qm74	614	30	the	the	DT
cord-015021-pol2qm74	614	31	extracted	extract	VBN
cord-015021-pol2qm74	614	32	DNA	dna	NN
cord-015021-pol2qm74	614	33	electrophoretically	electrophoretically	RB
cord-015021-pol2qm74	614	34	for	for	IN
cord-015021-pol2qm74	614	35	the	the	DT
cord-015021-pol2qm74	614	36	endogenous	endogenous	JJ
cord-015021-pol2qm74	614	37	endonuclease	endonuclease	NN
cord-015021-pol2qm74	614	38	activity	activity	NN
cord-015021-pol2qm74	615	1	The	the	DT
cord-015021-pol2qm74	615	2	results	result	NNS
cord-015021-pol2qm74	615	3	(	(	-LRB-
cord-015021-pol2qm74	615	4	n=6	n=6	NNP
cord-015021-pol2qm74	615	5	/	/	SYM
cord-015021-pol2qm74	615	6	grp	grp	NNP
cord-015021-pol2qm74	615	7	)	)	-RRB-
cord-015021-pol2qm74	615	8	indicate	indicate	VBP
cord-015021-pol2qm74	615	9	that	that	IN
cord-015021-pol2qm74	615	10	at	at	IN
cord-015021-pol2qm74	615	11	I	-PRON-	PRP
cord-015021-pol2qm74	616	1	h	h	NNP
cord-015021-pol2qm74	616	2	post	post	NNP
cord-015021-pol2qm74	616	3	-	-	NNP
cord-015021-pol2qm74	616	4	CLP	CLP	NNP
cord-015021-pol2qm74	616	5	there	there	EX
cord-015021-pol2qm74	616	6	was	be	VBD
cord-015021-pol2qm74	616	7	no	no	DT
cord-015021-pol2qm74	616	8	marked	marked	JJ
cord-015021-pol2qm74	616	9	changes	change	NNS
cord-015021-pol2qm74	616	10	in	in	IN
cord-015021-pol2qm74	616	11	any	any	DT
cord-015021-pol2qm74	616	12	of	of	IN
cord-015021-pol2qm74	616	13	these	these	DT
cord-015021-pol2qm74	616	14	parameters	parameter	NNS
cord-015021-pol2qm74	616	15	.	.	.
cord-015021-pol2qm74	617	1	However	however	RB
cord-015021-pol2qm74	617	2	,	,	,
cord-015021-pol2qm74	617	3	at	at	IN
cord-015021-pol2qm74	617	4	24	24	CD
cord-015021-pol2qm74	617	5	h	h	NN
cord-015021-pol2qm74	617	6	the	the	DT
cord-015021-pol2qm74	617	7	thymic	thymic	JJ
cord-015021-pol2qm74	617	8	cell	cell	NN
cord-015021-pol2qm74	617	9	yield	yield	NN
cord-015021-pol2qm74	617	10	from	from	IN
cord-015021-pol2qm74	617	11	CLP	CLP	NNP
cord-015021-pol2qm74	617	12	mice	mouse	NNS
cord-015021-pol2qm74	617	13	was	be	VBD
cord-015021-pol2qm74	617	14	significantly	significantly	RB
cord-015021-pol2qm74	617	15	decreased	decrease	VBN
cord-015021-pol2qm74	617	16	(	(	-LRB-
cord-015021-pol2qm74	617	17	Sham:3.6!0.2	Sham:3.6!0.2	NNP
cord-015021-pol2qm74	617	18	x	x	NNP
cord-015021-pol2qm74	617	19	l06	l06	CD
cord-015021-pol2qm74	617	20	vs	vs	IN
cord-015021-pol2qm74	617	21	CLP:0.3i0.1	CLP:0.3i0.1	NNP
cord-015021-pol2qm74	617	22	x	x	SYM
cord-015021-pol2qm74	617	23	106	106	CD
cord-015021-pol2qm74	617	24	*	*	NFP
cord-015021-pol2qm74	617	25	cells	cell	NNS
cord-015021-pol2qm74	617	26	;	;	:
cord-015021-pol2qm74	617	27	*	*	NFP
cord-015021-pol2qm74	617	28	,	,	,
cord-015021-pol2qm74	617	29	p<0.05	p<0.05	CD
cord-015021-pol2qm74	617	30	)	)	-RRB-
cord-015021-pol2qm74	617	31	,	,	,
cord-015021-pol2qm74	617	32	the	the	DT
cord-015021-pol2qm74	617	33	%	%	NN
cord-015021-pol2qm74	617	34	of	of	IN
cord-015021-pol2qm74	617	35	cells	cell	NNS
cord-015021-pol2qm74	617	36	apoptotic	apoptotic	JJ
cord-015021-pol2qm74	617	37	by	by	IN
cord-015021-pol2qm74	617	38	FACS	FACS	NNP
cord-015021-pol2qm74	617	39	analysis	analysis	NN
cord-015021-pol2qm74	617	40	increased	increase	VBD
cord-015021-pol2qm74	617	41	from	from	IN
cord-015021-pol2qm74	617	42	1.7i0.1	1.7i0.1	CD
cord-015021-pol2qm74	617	43	%	%	NN
cord-015021-pol2qm74	617	44	in	in	IN
cord-015021-pol2qm74	617	45	Sham	Sham	NNP
cord-015021-pol2qm74	617	46	to	to	IN
cord-015021-pol2qm74	617	47	8.7±3.2	8.7±3.2	NNP
cord-015021-pol2qm74	617	48	%	%	NN
cord-015021-pol2qm74	617	49	*	*	NFP
cord-015021-pol2qm74	617	50	in	in	IN
cord-015021-pol2qm74	617	51	CLP	CLP	NNP
cord-015021-pol2qm74	617	52	,	,	,
cord-015021-pol2qm74	617	53	and	and	CC
cord-015021-pol2qm74	617	54	the	the	DT
cord-015021-pol2qm74	617	55	septic	septic	JJ
cord-015021-pol2qm74	617	56	mouse	mouse	NN
cord-015021-pol2qm74	617	57	genomic	genomic	JJ
cord-015021-pol2qm74	617	58	DNA	DNA	NNP
cord-015021-pol2qm74	617	59	exhibited	exhibit	VBD
cord-015021-pol2qm74	617	60	DNA	dna	NN
cord-015021-pol2qm74	617	61	degradation	degradation	NN
cord-015021-pol2qm74	617	62	These	these	DT
cord-015021-pol2qm74	617	63	results	result	NNS
cord-015021-pol2qm74	617	64	indicate	indicate	VBP
cord-015021-pol2qm74	617	65	that	that	IN
cord-015021-pol2qm74	617	66	CLP	CLP	NNP
cord-015021-pol2qm74	617	67	,	,	,
cord-015021-pol2qm74	617	68	but	but	CC
cord-015021-pol2qm74	617	69	not	not	RB
cord-015021-pol2qm74	617	70	simple	simple	JJ
cord-015021-pol2qm74	617	71	laparotomy	laparotomy	NN
cord-015021-pol2qm74	617	72	,	,	,
cord-015021-pol2qm74	617	73	induces	induce	VBZ
cord-015021-pol2qm74	617	74	marked	mark	VBD
cord-015021-pol2qm74	617	75	thymic	thymic	JJ
cord-015021-pol2qm74	617	76	apetosis	apetosis	NN
cord-015021-pol2qm74	617	77	,	,	,
cord-015021-pol2qm74	617	78	which	which	WDT
cord-015021-pol2qm74	617	79	may	may	MD
cord-015021-pol2qm74	617	80	contribute	contribute	VB
cord-015021-pol2qm74	617	81	to	to	IN
cord-015021-pol2qm74	617	82	the	the	DT
cord-015021-pol2qm74	617	83	lymphocytic	lymphocytic	JJ
cord-015021-pol2qm74	617	84	immune	immune	JJ
cord-015021-pol2qm74	617	85	deficiency	deficiency	NN
cord-015021-pol2qm74	617	86	seen	see	VBN
cord-015021-pol2qm74	617	87	in	in	IN
cord-015021-pol2qm74	617	88	these	these	DT
cord-015021-pol2qm74	617	89	mice	mouse	NNS
cord-015021-pol2qm74	617	90	 	 	_SP
cord-015021-pol2qm74	618	1	The	the	DT
cord-015021-pol2qm74	618	2	purpose	purpose	NN
cord-015021-pol2qm74	618	3	of	of	IN
cord-015021-pol2qm74	618	4	this	this	DT
cord-015021-pol2qm74	618	5	retrospective	retrospective	JJ
cord-015021-pol2qm74	618	6	study	study	NN
cord-015021-pol2qm74	618	7	was	be	VBD
cord-015021-pol2qm74	618	8	to	to	TO
cord-015021-pol2qm74	618	9	evaluate	evaluate	VB
cord-015021-pol2qm74	618	10	effectiveness	effectiveness	NN
cord-015021-pol2qm74	618	11	of	of	IN
cord-015021-pol2qm74	618	12	irrigation	irrigation	NN
cord-015021-pol2qm74	618	13	to	to	TO
cord-015021-pol2qm74	618	14	treat	treat	VB
cord-015021-pol2qm74	618	15	septic	septic	JJ
cord-015021-pol2qm74	618	16	knee	knee	NN
cord-015021-pol2qm74	618	17	joints	joint	NNS
cord-015021-pol2qm74	618	18	from	from	IN
cord-015021-pol2qm74	618	19	longterm	longterm	JJ
cord-015021-pol2qm74	618	20	results	result	NNS
cord-015021-pol2qm74	618	21	.	.	.
cord-015021-pol2qm74	619	1	From	from	IN
cord-015021-pol2qm74	619	2	1982	1982	CD
cord-015021-pol2qm74	619	3	to	to	IN
cord-015021-pol2qm74	619	4	1992	1992	CD
cord-015021-pol2qm74	619	5	31	31	CD
cord-015021-pol2qm74	619	6	patients	patient	NNS
cord-015021-pol2qm74	619	7	with	with	IN
cord-015021-pol2qm74	619	8	septic	septic	JJ
cord-015021-pol2qm74	619	9	knee	knee	NN
cord-015021-pol2qm74	619	10	joints	joint	NNS
cord-015021-pol2qm74	619	11	have	have	VBP
cord-015021-pol2qm74	619	12	been	be	VBN
cord-015021-pol2qm74	619	13	treated	treat	VBN
cord-015021-pol2qm74	619	14	.	.	.
cord-015021-pol2qm74	620	1	Treatment	treatment	NN
cord-015021-pol2qm74	620	2	in	in	IN
cord-015021-pol2qm74	620	3	acute	acute	JJ
cord-015021-pol2qm74	620	4	cases	case	NNS
cord-015021-pol2qm74	620	5	started	start	VBD
cord-015021-pol2qm74	620	6	with	with	IN
cord-015021-pol2qm74	620	7	asp#at[on	asp#at[on	NNP
cord-015021-pol2qm74	620	8	of	of	IN
cord-015021-pol2qm74	620	9	the	the	DT
cord-015021-pol2qm74	620	10	effusion	effusion	NN
cord-015021-pol2qm74	620	11	to	to	TO
cord-015021-pol2qm74	620	12	evaluate	evaluate	VB
cord-015021-pol2qm74	620	13	for	for	IN
cord-015021-pol2qm74	620	14	cultures	culture	NNS
cord-015021-pol2qm74	620	15	.	.	.
cord-015021-pol2qm74	621	1	Without	without	IN
cord-015021-pol2qm74	621	2	awaiting	await	VBG
cord-015021-pol2qm74	621	3	the	the	DT
cord-015021-pol2qm74	621	4	result	result	NN
cord-015021-pol2qm74	621	5	treatment	treatment	NN
cord-015021-pol2qm74	621	6	was	be	VBD
cord-015021-pol2qm74	621	7	continued	continue	VBN
cord-015021-pol2qm74	621	8	with	with	IN
cord-015021-pol2qm74	621	9	immediate	immediate	JJ
cord-015021-pol2qm74	621	10	joint	joint	JJ
cord-015021-pol2qm74	621	11	irrigation	irrigation	NN
cord-015021-pol2qm74	621	12	under	under	IN
cord-015021-pol2qm74	621	13	arthroscopic	arthroscopic	JJ
cord-015021-pol2qm74	621	14	control	control	NN
cord-015021-pol2qm74	621	15	.	.	.
cord-015021-pol2qm74	622	1	Three	three	CD
cord-015021-pol2qm74	622	2	redon	redon	NNP
cord-015021-pol2qm74	622	3	tubes	tube	NNS
cord-015021-pol2qm74	622	4	(	(	-LRB-
cord-015021-pol2qm74	622	5	CH	CH	NNP
cord-015021-pol2qm74	622	6	16	16	CD
cord-015021-pol2qm74	622	7	)	)	-RRB-
cord-015021-pol2qm74	622	8	were	be	VBD
cord-015021-pol2qm74	622	9	introduced	introduce	VBN
cord-015021-pol2qm74	622	10	for	for	IN
cord-015021-pol2qm74	622	11	continuous	continuous	JJ
cord-015021-pol2qm74	622	12	irrigation	irrigation	NN
cord-015021-pol2qm74	622	13	and	and	CC
cord-015021-pol2qm74	622	14	for	for	IN
cord-015021-pol2qm74	622	15	intermittent	intermittent	JJ
cord-015021-pol2qm74	622	16	distention	distention	NN
cord-015021-pol2qm74	622	17	of	of	IN
cord-015021-pol2qm74	622	18	the	the	DT
cord-015021-pol2qm74	622	19	joint	joint	JJ
cord-015021-pol2qm74	622	20	cavity	cavity	NN
cord-015021-pol2qm74	622	21	.	.	.
cord-015021-pol2qm74	623	1	In	in	IN
cord-015021-pol2qm74	623	2	case	case	NN
cord-015021-pol2qm74	623	3	of	of	IN
cord-015021-pol2qm74	623	4	chronic	chronic	JJ
cord-015021-pol2qm74	623	5	joint	joint	JJ
cord-015021-pol2qm74	623	6	infection	infection	NN
cord-015021-pol2qm74	623	7	additionally	additionally	RB
cord-015021-pol2qm74	623	8	all	all	DT
cord-015021-pol2qm74	623	9	foreign	foreign	JJ
cord-015021-pol2qm74	623	10	and	and	CC
cord-015021-pol2qm74	623	11	synthetic	synthetic	JJ
cord-015021-pol2qm74	623	12	material	material	NN
cord-015021-pol2qm74	623	13	was	be	VBD
cord-015021-pol2qm74	623	14	removed	remove	VBN
cord-015021-pol2qm74	623	15	.	.	.
cord-015021-pol2qm74	624	1	Systemic	systemic	JJ
cord-015021-pol2qm74	624	2	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	624	3	were	be	VBD
cord-015021-pol2qm74	624	4	given	give	VBN
cord-015021-pol2qm74	624	5	.	.	.
cord-015021-pol2qm74	625	1	Patients	patient	NNS
cord-015021-pol2qm74	625	2	could	could	MD
cord-015021-pol2qm74	625	3	be	be	VB
cord-015021-pol2qm74	625	4	re	re	VBN
cord-015021-pol2qm74	625	5	-examined	-examine	VBN
cord-015021-pol2qm74	625	6	with	with	IN
cord-015021-pol2qm74	625	7	a	a	DT
cord-015021-pol2qm74	625	8	mean	mean	JJ
cord-015021-pol2qm74	625	9	follow	follow	NN
cord-015021-pol2qm74	625	10	-	-	HYPH
cord-015021-pol2qm74	625	11	up	up	NN
cord-015021-pol2qm74	625	12	of	of	IN
cord-015021-pol2qm74	625	13	6	6	CD
cord-015021-pol2qm74	625	14	years	year	NNS
cord-015021-pol2qm74	625	15	.	.	.
cord-015021-pol2qm74	626	1	Re	re	NN
cord-015021-pol2qm74	626	2	-	-	NN
cord-015021-pol2qm74	626	3	examination	examination	NN
cord-015021-pol2qm74	626	4	showed	show	VBD
cord-015021-pol2qm74	626	5	that	that	IN
cord-015021-pol2qm74	626	6	immediate	immediate	JJ
cord-015021-pol2qm74	626	7	arthroscopic	arthroscopic	JJ
cord-015021-pol2qm74	626	8	lavage	lavage	NN
cord-015021-pol2qm74	626	9	started	start	VBD
cord-015021-pol2qm74	626	10	at	at	IN
cord-015021-pol2qm74	626	11	the	the	DT
cord-015021-pol2qm74	626	12	onset	onset	NN
cord-015021-pol2qm74	626	13	of	of	IN
cord-015021-pol2qm74	626	14	septic	septic	NN
cord-015021-pol2qm74	626	15	sings	sing	NNS
cord-015021-pol2qm74	626	16	had	have	VBD
cord-015021-pol2qm74	626	17	best	good	JJS
cord-015021-pol2qm74	626	18	results	result	NNS
cord-015021-pol2qm74	626	19	(	(	-LRB-
cord-015021-pol2qm74	626	20	less	less	JJR
cord-015021-pol2qm74	626	21	signs	sign	NNS
cord-015021-pol2qm74	626	22	of	of	IN
cord-015021-pol2qm74	626	23	osteoarthr[tis	osteoarthr[tis	NNP
cord-015021-pol2qm74	626	24	,	,	,
cord-015021-pol2qm74	626	25	less	less	RBR
cord-015021-pol2qm74	626	26	synovitis	synovitis	JJ
cord-015021-pol2qm74	626	27	,	,	,
cord-015021-pol2qm74	626	28	less	less	JJR
cord-015021-pol2qm74	626	29	pain	pain	NN
cord-015021-pol2qm74	626	30	while	while	IN
cord-015021-pol2qm74	626	31	loading	load	VBG
cord-015021-pol2qm74	626	32	and	and	CC
cord-015021-pol2qm74	626	33	less	less	JJR
cord-015021-pol2qm74	626	34	range	range	NN
cord-015021-pol2qm74	626	35	of	of	IN
cord-015021-pol2qm74	626	36	motion	motion	NN
cord-015021-pol2qm74	626	37	loss	loss	NN
cord-015021-pol2qm74	626	38	)	)	-RRB-
cord-015021-pol2qm74	626	39	.	.	.
cord-015021-pol2qm74	627	1	21	21	CD
cord-015021-pol2qm74	627	2	patients	patient	NNS
cord-015021-pol2qm74	627	3	(	(	-LRB-
cord-015021-pol2qm74	627	4	80	80	CD
cord-015021-pol2qm74	627	5	%	%	NN
cord-015021-pol2qm74	627	6	)	)	-RRB-
cord-015021-pol2qm74	627	7	out	out	IN
cord-015021-pol2qm74	627	8	of	of	IN
cord-015021-pol2qm74	627	9	26	26	CD
cord-015021-pol2qm74	627	10	patients	patient	NNS
cord-015021-pol2qm74	627	11	with	with	IN
cord-015021-pol2qm74	627	12	s	s	NN
cord-015021-pol2qm74	628	1	tre_=.tsd	tre_=.tsd	NNP
cord-015021-pol2qm74	628	2	acute	acute	JJ
cord-015021-pol2qm74	628	3	se.~tic	se.~tic	JJ
cord-015021-pol2qm74	628	4	knee	knee	NN
cord-015021-pol2qm74	628	5	joint	joint	NN
cord-015021-pol2qm74	628	6	had	have	VBD
cord-015021-pol2qm74	628	7	excellent	excellent	JJ
cord-015021-pol2qm74	628	8	functional	functional	JJ
cord-015021-pol2qm74	628	9	recovery	recovery	NN
cord-015021-pol2qm74	628	10	,	,	,
cord-015021-pol2qm74	628	11	whereas	whereas	IN
cord-015021-pol2qm74	628	12	all	all	DT
cord-015021-pol2qm74	628	13	5	5	CD
cord-015021-pol2qm74	628	14	patients	patient	NNS
cord-015021-pol2qm74	628	15	with	with	IN
cord-015021-pol2qm74	628	16	chronic	chronic	JJ
cord-015021-pol2qm74	628	17	septic	septic	JJ
cord-015021-pol2qm74	628	18	knee	knee	NN
cord-015021-pol2qm74	628	19	joints	joint	NNS
cord-015021-pol2qm74	628	20	showed	show	VBD
cord-015021-pol2qm74	628	21	poor	poor	JJ
cord-015021-pol2qm74	628	22	results	result	NNS
cord-015021-pol2qm74	628	23	.	.	.
cord-015021-pol2qm74	629	1	Additionally	additionally	RB
cord-015021-pol2qm74	629	2	,	,	,
cord-015021-pol2qm74	629	3	in	in	IN
cord-015021-pol2qm74	629	4	3	3	CD
cord-015021-pol2qm74	629	5	of	of	IN
cord-015021-pol2qm74	629	6	these	these	DT
cord-015021-pol2qm74	629	7	5	5	CD
cord-015021-pol2qm74	629	8	patients	patient	NNS
cord-015021-pol2qm74	629	9	with	with	IN
cord-015021-pol2qm74	629	10	chronic	chronic	JJ
cord-015021-pol2qm74	629	11	septic	septic	JJ
cord-015021-pol2qm74	629	12	knee	knee	NN
cord-015021-pol2qm74	629	13	joint	joint	NN
cord-015021-pol2qm74	629	14	after	after	IN
cord-015021-pol2qm74	629	15	irrigation	irrigation	NN
cord-015021-pol2qm74	629	16	a	a	DT
cord-015021-pol2qm74	629	17	further	further	JJ
cord-015021-pol2qm74	629	18	procedure	procedure	NN
cord-015021-pol2qm74	629	19	was	be	VBD
cord-015021-pol2qm74	629	20	necessary	necessary	JJ
cord-015021-pol2qm74	629	21	due	due	IN
cord-015021-pol2qm74	629	22	to	to	IN
cord-015021-pol2qm74	629	23	recurrent	recurrent	JJ
cord-015021-pol2qm74	629	24	septic	septic	JJ
cord-015021-pol2qm74	629	25	knee	knee	NN
cord-015021-pol2qm74	629	26	joint	joint	NN
cord-015021-pol2qm74	629	27	.	.	.
cord-015021-pol2qm74	630	1	The	the	DT
cord-015021-pol2qm74	630	2	concept	concept	NN
cord-015021-pol2qm74	630	3	that	that	IN
cord-015021-pol2qm74	630	4	bacteria	bacteria	NNS
cord-015021-pol2qm74	630	5	can	can	MD
cord-015021-pol2qm74	630	6	translocate	translocate	VB
cord-015021-pol2qm74	630	7	across	across	IN
cord-015021-pol2qm74	630	8	the	the	DT
cord-015021-pol2qm74	630	9	intestinal	intestinal	JJ
cord-015021-pol2qm74	630	10	mucosa	mucosa	NN
cord-015021-pol2qm74	630	11	under	under	IN
cord-015021-pol2qm74	630	12	a	a	DT
cord-015021-pol2qm74	630	13	variety	variety	NN
cord-015021-pol2qm74	630	14	of	of	IN
cord-015021-pol2qm74	630	15	circumstances	circumstance	NNS
cord-015021-pol2qm74	630	16	is	be	VBZ
cord-015021-pol2qm74	630	17	well	well	RB
cord-015021-pol2qm74	630	18	established	establish	VBN
cord-015021-pol2qm74	630	19	.	.	.
cord-015021-pol2qm74	631	1	However	however	RB
cord-015021-pol2qm74	631	2	,	,	,
cord-015021-pol2qm74	631	3	due	due	IN
cord-015021-pol2qm74	631	4	to	to	IN
cord-015021-pol2qm74	631	5	the	the	DT
cord-015021-pol2qm74	631	6	inherent	inherent	JJ
cord-015021-pol2qm74	631	7	limitations	limitation	NNS
cord-015021-pol2qm74	631	8	of	of	IN
cord-015021-pol2qm74	631	9	in	in	IN
cord-015021-pol2qm74	631	10	vivo	vivo	NNP
cord-015021-pol2qm74	631	11	studies	study	NNS
cord-015021-pol2qm74	631	12	,	,	,
cord-015021-pol2qm74	631	13	the	the	DT
cord-015021-pol2qm74	631	14	cellular	cellular	JJ
cord-015021-pol2qm74	631	15	mechanisms	mechanism	NNS
cord-015021-pol2qm74	631	16	underlying	underlie	VBG
cord-015021-pol2qm74	631	17	the	the	DT
cord-015021-pol2qm74	631	18	process	process	NN
cord-015021-pol2qm74	631	19	of	of	IN
cord-015021-pol2qm74	631	20	bacterial	bacterial	JJ
cord-015021-pol2qm74	631	21	translocation	translocation	NN
cord-015021-pol2qm74	631	22	(	(	-LRB-
cord-015021-pol2qm74	631	23	BT	BT	NNP
cord-015021-pol2qm74	631	24	)	)	-RRB-
cord-015021-pol2qm74	631	25	across	across	IN
cord-015021-pol2qm74	631	26	the	the	DT
cord-015021-pol2qm74	631	27	epithelial	epithelial	JJ
cord-015021-pol2qm74	631	28	barrier	barrier	NN
cord-015021-pol2qm74	631	29	are	be	VBP
cord-015021-pol2qm74	631	30	poorly	poorly	RB
cord-015021-pol2qm74	631	31	understood	understand	VBN
cord-015021-pol2qm74	631	32	.	.	.
cord-015021-pol2qm74	632	1	This	this	DT
cord-015021-pol2qm74	632	2	is	be	VBZ
cord-015021-pol2qm74	632	3	especially	especially	RB
cord-015021-pol2qm74	632	4	true	true	JJ
cord-015021-pol2qm74	632	5	in	in	IN
cord-015021-pol2qm74	632	6	those	those	DT
cord-015021-pol2qm74	632	7	circumstances	circumstance	NNS
cord-015021-pol2qm74	632	8	in	in	IN
cord-015021-pol2qm74	632	9	which	which	WDT
cord-015021-pol2qm74	632	10	there	there	EX
cord-015021-pol2qm74	632	11	is	be	VBZ
cord-015021-pol2qm74	632	12	no	no	DT
cord-015021-pol2qm74	632	13	merphologic	merphologic	JJ
cord-015021-pol2qm74	632	14	evidence	evidence	NN
cord-015021-pol2qm74	632	15	of	of	IN
cord-015021-pol2qm74	632	16	mucosal	mucosal	JJ
cord-015021-pol2qm74	632	17	injury	injury	NN
cord-015021-pol2qm74	632	18	.	.	.
cord-015021-pol2qm74	633	1	Consequently	consequently	RB
cord-015021-pol2qm74	633	2	,	,	,
cord-015021-pol2qm74	633	3	we	-PRON-	PRP
cord-015021-pol2qm74	633	4	have	have	VBP
cord-015021-pol2qm74	633	5	utilized	utilize	VBN
cord-015021-pol2qm74	633	6	an	an	DT
cord-015021-pol2qm74	633	7	in	in	IN
cord-015021-pol2qm74	633	8	vitro	vitro	FW
cord-015021-pol2qm74	633	9	cell	cell	NN
cord-015021-pol2qm74	633	10	culture	culture	NN
cord-015021-pol2qm74	633	11	model	model	NN
cord-015021-pol2qm74	633	12	system	system	NN
cord-015021-pol2qm74	633	13	to	to	TO
cord-015021-pol2qm74	633	14	investigate	investigate	VB
cord-015021-pol2qm74	633	15	the	the	DT
cord-015021-pol2qm74	633	16	cellular	cellular	JJ
cord-015021-pol2qm74	633	17	events	event	NNS
cord-015021-pol2qm74	633	18	involved	involve	VBN
cord-015021-pol2qm74	633	19	in	in	IN
cord-015021-pol2qm74	633	20	the	the	DT
cord-015021-pol2qm74	633	21	translocation	translocation	NN
cord-015021-pol2qm74	633	22	process	process	NN
cord-015021-pol2qm74	633	23	.	.	.
cord-015021-pol2qm74	634	1	In	in	IN
cord-015021-pol2qm74	634	2	this	this	DT
cord-015021-pol2qm74	634	3	model	model	NN
cord-015021-pol2qm74	634	4	system	system	NN
cord-015021-pol2qm74	634	5	,	,	,
cord-015021-pol2qm74	634	6	a	a	DT
cord-015021-pol2qm74	634	7	polarized	polarized	JJ
cord-015021-pol2qm74	634	8	monolayer	monolayer	NN
cord-015021-pol2qm74	634	9	of	of	IN
cord-015021-pol2qm74	634	10	intestinal	intestinal	JJ
cord-015021-pol2qm74	634	11	cells	cell	NNS
cord-015021-pol2qm74	634	12	(	(	-LRB-
cord-015021-pol2qm74	634	13	Caco-2	caco-2	NN
cord-015021-pol2qm74	634	14	cell	cell	NN
cord-015021-pol2qm74	634	15	line	line	NN
cord-015021-pol2qm74	634	16	)	)	-RRB-
cord-015021-pol2qm74	634	17	is	be	VBZ
cord-015021-pol2qm74	634	18	grown	grow	VBN
cord-015021-pol2qm74	634	19	on	on	IN
cord-015021-pol2qm74	634	20	a	a	DT
cord-015021-pol2qm74	634	21	3	3	CD
cord-015021-pol2qm74	634	22	micron	micron	NN
cord-015021-pol2qm74	634	23	filter	filter	NN
cord-015021-pol2qm74	634	24	in	in	IN
cord-015021-pol2qm74	634	25	a	a	DT
cord-015021-pol2qm74	634	26	two	two	CD
cord-015021-pol2qm74	634	27	compartment	compartment	NN
cord-015021-pol2qm74	634	28	system	system	NN
cord-015021-pol2qm74	634	29	.	.	.
cord-015021-pol2qm74	635	1	After	after	IN
cord-015021-pol2qm74	635	2	tight	tight	JJ
cord-015021-pol2qm74	635	3	junction	junction	NN
cord-015021-pol2qm74	635	4	integrity	integrity	NN
cord-015021-pol2qm74	635	5	is	be	VBZ
cord-015021-pol2qm74	635	6	established	establish	VBN
cord-015021-pol2qm74	635	7	,	,	,
cord-015021-pol2qm74	635	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	635	9	are	be	VBP
cord-015021-pol2qm74	635	10	placed	place	VBN
cord-015021-pol2qm74	635	11	in	in	IN
cord-015021-pol2qm74	635	12	the	the	DT
cord-015021-pol2qm74	635	13	apical	apical	JJ
cord-015021-pol2qm74	635	14	surface	surface	NN
cord-015021-pol2qm74	635	15	chamber	chamber	NN
cord-015021-pol2qm74	635	16	and	and	CC
cord-015021-pol2qm74	635	17	BT	BT	NNP
cord-015021-pol2qm74	635	18	across	across	IN
cord-015021-pol2qm74	635	19	the	the	DT
cord-015021-pol2qm74	635	20	Caco-2	caco-2	NN
cord-015021-pol2qm74	635	21	monolayer	monolayer	NN
cord-015021-pol2qm74	635	22	is	be	VBZ
cord-015021-pol2qm74	635	23	measured	measure	VBN
cord-015021-pol2qm74	635	24	by	by	IN
cord-015021-pol2qm74	635	25	culturing	culture	VBG
cord-015021-pol2qm74	635	26	the	the	DT
cord-015021-pol2qm74	635	27	basal	basal	NN
cord-015021-pol2qm74	635	28	chamber	chamber	NN
cord-015021-pol2qm74	635	29	.	.	.
cord-015021-pol2qm74	636	1	The	the	DT
cord-015021-pol2qm74	636	2	results	result	NNS
cord-015021-pol2qm74	636	3	of	of	IN
cord-015021-pol2qm74	636	4	our	-PRON-	PRP$
cord-015021-pol2qm74	636	5	studies	study	NNS
cord-015021-pol2qm74	636	6	utilizing	utilize	VBG
cord-015021-pol2qm74	636	7	the	the	DT
cord-015021-pol2qm74	636	8	Caco-2	Caco-2	NNP
cord-015021-pol2qm74	636	9	system	system	NN
cord-015021-pol2qm74	636	10	indicates	indicate	VBZ
cord-015021-pol2qm74	636	11	that	that	IN
cord-015021-pol2qm74	636	12	;	;	:
cord-015021-pol2qm74	636	13	l	l	LS
cord-015021-pol2qm74	636	14	)	)	-RRB-
cord-015021-pol2qm74	636	15	Several	several	JJ
cord-015021-pol2qm74	636	16	strains	strain	NNS
cord-015021-pol2qm74	636	17	of	of	IN
cord-015021-pol2qm74	636	18	non	non	JJ
cord-015021-pol2qm74	636	19	-	-	JJ
cord-015021-pol2qm74	636	20	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	636	21	bacteria	bacteria	NNS
cord-015021-pol2qm74	636	22	will	will	MD
cord-015021-pol2qm74	636	23	translocate	translocate	VB
cord-015021-pol2qm74	636	24	across	across	IN
cord-015021-pol2qm74	636	25	the	the	DT
cord-015021-pol2qm74	636	26	Caco-2	Caco-2	NNP
cord-015021-pol2qm74	636	27	monolayer	monolayer	NN
cord-015021-pol2qm74	636	28	in	in	IN
cord-015021-pol2qm74	636	29	a	a	DT
cord-015021-pol2qm74	636	30	time	time	NN
cord-015021-pol2qm74	636	31	-	-	HYPH
cord-015021-pol2qm74	636	32	dependent	dependent	JJ
cord-015021-pol2qm74	636	33	and	and	CC
cord-015021-pol2qm74	636	34	dose	dose	NN
cord-015021-pol2qm74	636	35	-	-	HYPH
cord-015021-pol2qm74	636	36	dependent	dependent	JJ
cord-015021-pol2qm74	636	37	fashion	fashion	NN
cord-015021-pol2qm74	636	38	.	.	.
cord-015021-pol2qm74	637	1	However	however	RB
cord-015021-pol2qm74	637	2	,	,	,
cord-015021-pol2qm74	637	3	the	the	DT
cord-015021-pol2qm74	637	4	incidence	incidence	NN
cord-015021-pol2qm74	637	5	and	and	CC
cord-015021-pol2qm74	637	6	magnitude	magnitude	NN
cord-015021-pol2qm74	637	7	of	of	IN
cord-015021-pol2qm74	637	8	BT	BT	NNP
cord-015021-pol2qm74	637	9	are	be	VBP
cord-015021-pol2qm74	637	10	highest	high	JJS
cord-015021-pol2qm74	637	11	for	for	IN
cord-015021-pol2qm74	637	12	those	those	DT
cord-015021-pol2qm74	637	13	strains	strain	NNS
cord-015021-pol2qm74	637	14	of	of	IN
cord-015021-pol2qm74	637	15	bacteria	bacteria	NNS
cord-015021-pol2qm74	637	16	(	(	-LRB-
cord-015021-pol2qm74	637	17	gram	gram	JJ
cord-015021-pol2qm74	637	18	-	-	HYPH
cord-015021-pol2qm74	637	19	negative	negative	JJ
cord-015021-pol2qm74	637	20	enterics	enteric	NNS
cord-015021-pol2qm74	637	21	)	)	-RRB-
cord-015021-pol2qm74	637	22	that	that	WDT
cord-015021-pol2qm74	637	23	are	be	VBP
cord-015021-pol2qm74	637	24	most	most	RBS
cord-015021-pol2qm74	637	25	commonly	commonly	RB
cord-015021-pol2qm74	637	26	cultured	culture	VBN
cord-015021-pol2qm74	637	27	in	in	IN
cord-015021-pol2qm74	637	28	vivo	vivo	NN
cord-015021-pol2qm74	637	29	.	.	.
cord-015021-pol2qm74	638	1	2	2	LS
cord-015021-pol2qm74	638	2	)	)	-RRB-
cord-015021-pol2qm74	639	1	Caco-2	caco-2	NN
cord-015021-pol2qm74	639	2	cells	cell	NNS
cord-015021-pol2qm74	639	3	are	be	VBP
cord-015021-pol2qm74	639	4	actively	actively	RB
cord-015021-pol2qm74	639	5	involved	involve	VBN
cord-015021-pol2qm74	639	6	in	in	IN
cord-015021-pol2qm74	639	7	the	the	DT
cord-015021-pol2qm74	639	8	transcellular	transcellular	JJ
cord-015021-pol2qm74	639	9	passage	passage	NN
cord-015021-pol2qm74	639	10	of	of	IN
cord-015021-pol2qm74	639	11	bacteria	bacteria	NNS
cord-015021-pol2qm74	639	12	across	across	IN
cord-015021-pol2qm74	639	13	the	the	DT
cord-015021-pol2qm74	639	14	Caco-2	Caco-2	NNP
cord-015021-pol2qm74	639	15	monolayer	monolayer	NN
cord-015021-pol2qm74	639	16	,	,	,
cord-015021-pol2qm74	639	17	since	since	IN
cord-015021-pol2qm74	639	18	inhibition	inhibition	NN
cord-015021-pol2qm74	639	19	of	of	IN
cord-015021-pol2qm74	639	20	Caco-2	Caco-2	NNP
cord-015021-pol2qm74	639	21	microtubule	microtubule	NN
cord-015021-pol2qm74	639	22	or	or	CC
cord-015021-pol2qm74	639	23	microfilament	microfilament	NN
cord-015021-pol2qm74	639	24	function	function	NN
cord-015021-pol2qm74	639	25	decreases	decrease	VBZ
cord-015021-pol2qm74	639	26	the	the	DT
cord-015021-pol2qm74	639	27	magnitude	magnitude	NN
cord-015021-pol2qm74	639	28	of	of	IN
cord-015021-pol2qm74	639	29	ST	ST	NNP
cord-015021-pol2qm74	639	30	.	.	.
cord-015021-pol2qm74	640	1	3	3	LS
cord-015021-pol2qm74	640	2	)	)	-RRB-
cord-015021-pol2qm74	641	1	Lectin	Lectin	NNP
cord-015021-pol2qm74	641	2	but	but	CC
cord-015021-pol2qm74	641	3	not	not	RB
cord-015021-pol2qm74	641	4	integrin	integrin	JJ
cord-015021-pol2qm74	641	5	receptors	receptor	NNS
cord-015021-pol2qm74	641	6	are	be	VBP
cord-015021-pol2qm74	641	7	involved	involve	VBN
cord-015021-pol2qm74	641	8	in	in	IN
cord-015021-pol2qm74	641	9	bacterial	bacterial	JJ
cord-015021-pol2qm74	641	10	translocation	translocation	NN
cord-015021-pol2qm74	641	11	of	of	IN
cord-015021-pol2qm74	641	12	E.	E.	NNP
cord-015021-pol2qm74	641	13	col~	col~	NNP
cord-015021-pol2qm74	641	14	across	across	IN
cord-015021-pol2qm74	641	15	the	the	DT
cord-015021-pol2qm74	641	16	Caco-2	Caco-2	NNP
cord-015021-pol2qm74	641	17	cell	cell	NN
cord-015021-pol2qm74	641	18	monolayer	monolayer	NN
cord-015021-pol2qm74	641	19	.	.	.
cord-015021-pol2qm74	642	1	4	4	LS
cord-015021-pol2qm74	642	2	)	)	-RRB-
cord-015021-pol2qm74	643	1	Caco-2	caco-2	NN
cord-015021-pol2qm74	643	2	cells	cell	NNS
cord-015021-pol2qm74	643	3	have	have	VBP
cord-015021-pol2qm74	643	4	the	the	DT
cord-015021-pol2qm74	643	5	ability	ability	NN
cord-015021-pol2qm74	643	6	to	to	TO
cord-015021-pol2qm74	643	7	ingest	ingest	VB
cord-015021-pol2qm74	643	8	and	and	CC
cord-015021-pol2qm74	643	9	kill	kill	VB
cord-015021-pol2qm74	643	10	certain	certain	JJ
cord-015021-pol2qm74	643	11	strains	strain	NNS
cord-015021-pol2qm74	643	12	of	of	IN
cord-015021-pol2qm74	643	13	bacteria	bacteria	NNS
cord-015021-pol2qm74	643	14	.	.	.
cord-015021-pol2qm74	644	1	The	the	DT
cord-015021-pol2qm74	644	2	mechanisms	mechanism	NNS
cord-015021-pol2qm74	644	3	involved	involve	VBN
cord-015021-pol2qm74	644	4	in	in	IN
cord-015021-pol2qm74	644	5	Caco-2	caco-2	NN
cord-015021-pol2qm74	644	6	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	644	7	activity	activity	NN
cord-015021-pol2qm74	644	8	appear	appear	VBP
cord-015021-pol2qm74	644	9	similar	similar	JJ
cord-015021-pol2qm74	644	10	to	to	IN
cord-015021-pol2qm74	644	11	that	that	DT
cord-015021-pol2qm74	644	12	of	of	IN
cord-015021-pol2qm74	644	13	PMNs	pmn	NNS
cord-015021-pol2qm74	644	14	to	to	IN
cord-015021-pol2qm74	644	15	the	the	DT
cord-015021-pol2qm74	644	16	extent	extent	NN
cord-015021-pol2qm74	644	17	that	that	IN
cord-015021-pol2qm74	644	18	both	both	DT
cord-015021-pol2qm74	644	19	are	be	VBP
cord-015021-pol2qm74	644	20	oxidant	oxidant	JJ
cord-015021-pol2qm74	644	21	but	but	CC
cord-015021-pol2qm74	644	22	not	not	RB
cord-015021-pol2qm74	644	23	nitric	nitric	JJ
cord-015021-pol2qm74	644	24	oxide	oxide	NN
cord-015021-pol2qm74	644	25	mediated	mediate	VBN
cord-015021-pol2qm74	644	26	.	.	.
cord-015021-pol2qm74	645	1	These	these	DT
cord-015021-pol2qm74	645	2	in	in	IN
cord-015021-pol2qm74	645	3	vitro	vitro	FW
cord-015021-pol2qm74	645	4	studies	study	NNS
cord-015021-pol2qm74	645	5	suggest	suggest	VBP
cord-015021-pol2qm74	645	6	that	that	IN
cord-015021-pol2qm74	645	7	Caco-2	caco-2	NN
cord-015021-pol2qm74	645	8	cells	cell	NNS
cord-015021-pol2qm74	645	9	can	can	MD
cord-015021-pol2qm74	645	10	function	function	VB
cord-015021-pol2qm74	645	11	as	as	IN
cord-015021-pol2qm74	645	12	"	"	``
cord-015021-pol2qm74	645	13	nonprofessional	nonprofessional	JJ
cord-015021-pol2qm74	645	14	"	"	''
cord-015021-pol2qm74	645	15	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	645	16	and	and	CC
cord-015021-pol2qm74	645	17	that	that	IN
cord-015021-pol2qm74	645	18	both	both	DT
cord-015021-pol2qm74	645	19	bacteria	bacteria	NNS
cord-015021-pol2qm74	645	20	and	and	CC
cord-015021-pol2qm74	645	21	enterocytes	enterocyte	NNS
cord-015021-pol2qm74	645	22	are	be	VBP
cord-015021-pol2qm74	645	23	involved	involve	VBN
cord-015021-pol2qm74	645	24	in	in	IN
cord-015021-pol2qm74	645	25	the	the	DT
cord-015021-pol2qm74	645	26	translecation	translecation	NN
cord-015021-pol2qm74	645	27	phenomenon	phenomenon	NN
cord-015021-pol2qm74	645	28	.	.	.
cord-015021-pol2qm74	646	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	646	2	translocation	translocation	NN
cord-015021-pol2qm74	646	3	due	due	IN
cord-015021-pol2qm74	646	4	to	to	IN
cord-015021-pol2qm74	646	5	gut	gut	VB
cord-015021-pol2qm74	646	6	barrier	barrier	NN
cord-015021-pol2qm74	646	7	dysfunction	dysfunction	NN
cord-015021-pol2qm74	646	8	is	be	VBZ
cord-015021-pol2qm74	646	9	considered	consider	VBN
cord-015021-pol2qm74	646	10	to	to	TO
cord-015021-pol2qm74	646	11	be	be	VB
cord-015021-pol2qm74	646	12	a	a	DT
cord-015021-pol2qm74	646	13	major	major	JJ
cord-015021-pol2qm74	646	14	cause	cause	NN
cord-015021-pol2qm74	646	15	of	of	IN
cord-015021-pol2qm74	646	16	septic	septic	JJ
cord-015021-pol2qm74	646	17	complications	complication	NNS
cord-015021-pol2qm74	646	18	and	and	CC
cord-015021-pol2qm74	646	19	multiple	multiple	JJ
cord-015021-pol2qm74	646	20	organ	organ	NN
cord-015021-pol2qm74	646	21	failure	failure	NN
cord-015021-pol2qm74	646	22	following	follow	VBG
cord-015021-pol2qm74	646	23	trauma	trauma	NN
cord-015021-pol2qm74	646	24	,	,	,
cord-015021-pol2qm74	646	25	burn	burn	VB
cord-015021-pol2qm74	646	26	injury	injury	NN
cord-015021-pol2qm74	646	27	,	,	,
cord-015021-pol2qm74	646	28	hypoxia	hypoxia	NN
cord-015021-pol2qm74	646	29	,	,	,
cord-015021-pol2qm74	646	30	shock	shock	NN
cord-015021-pol2qm74	646	31	and	and	CC
cord-015021-pol2qm74	646	32	shock	shock	NN
cord-015021-pol2qm74	646	33	-	-	HYPH
cord-015021-pol2qm74	646	34	like	like	JJ
cord-015021-pol2qm74	646	35	states	state	NNS
cord-015021-pol2qm74	646	36	.	.	.
cord-015021-pol2qm74	647	1	The	the	DT
cord-015021-pol2qm74	647	2	invasion	invasion	NN
cord-015021-pol2qm74	647	3	of	of	IN
cord-015021-pol2qm74	647	4	bacteria	bacteria	NNS
cord-015021-pol2qm74	647	5	into	into	IN
cord-015021-pol2qm74	647	6	the	the	DT
cord-015021-pol2qm74	647	7	circulation	circulation	NN
cord-015021-pol2qm74	647	8	from	from	IN
cord-015021-pol2qm74	647	9	the	the	DT
cord-015021-pol2qm74	647	10	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	647	11	tract	tract	NN
cord-015021-pol2qm74	647	12	or	or	CC
cord-015021-pol2qm74	647	13	even	even	RB
cord-015021-pol2qm74	647	14	from	from	IN
cord-015021-pol2qm74	647	15	other	other	JJ
cord-015021-pol2qm74	647	16	sources	source	NNS
cord-015021-pol2qm74	647	17	,	,	,
cord-015021-pol2qm74	647	18	however	however	RB
cord-015021-pol2qm74	647	19	,	,	,
cord-015021-pol2qm74	647	20	should	should	MD
cord-015021-pol2qm74	647	21	not	not	RB
cord-015021-pol2qm74	647	22	necessarily	necessarily	RB
cord-015021-pol2qm74	647	23	result	result	VB
cord-015021-pol2qm74	647	24	in	in	IN
cord-015021-pol2qm74	647	25	systemic	systemic	JJ
cord-015021-pol2qm74	647	26	infection	infection	NN
cord-015021-pol2qm74	647	27	or	or	CC
cord-015021-pol2qm74	647	28	organ	organ	NN
cord-015021-pol2qm74	647	29	cohinisation	cohinisation	NN
cord-015021-pol2qm74	647	30	,	,	,
cord-015021-pol2qm74	647	31	as	as	RB
cord-015021-pol2qm74	647	32	long	long	RB
cord-015021-pol2qm74	647	33	as	as	IN
cord-015021-pol2qm74	647	34	the	the	DT
cord-015021-pol2qm74	647	35	humoral	humoral	JJ
cord-015021-pol2qm74	647	36	and	and	CC
cord-015021-pol2qm74	647	37	cellular	cellular	JJ
cord-015021-pol2qm74	647	38	defense	defense	NN
cord-015021-pol2qm74	647	39	mechanisms	mechanism	NNS
cord-015021-pol2qm74	647	40	are	be	VBP
cord-015021-pol2qm74	647	41	not	not	RB
cord-015021-pol2qm74	647	42	impaired	impaired	JJ
cord-015021-pol2qm74	647	43	.	.	.
cord-015021-pol2qm74	648	1	Thus	thus	RB
cord-015021-pol2qm74	648	2	,	,	,
cord-015021-pol2qm74	648	3	a	a	DT
cord-015021-pol2qm74	648	4	reduced	reduce	VBN
cord-015021-pol2qm74	648	5	RES	res	NN
cord-015021-pol2qm74	648	6	clearance	clearance	NN
cord-015021-pol2qm74	648	7	capacity	capacity	NN
cord-015021-pol2qm74	648	8	and	and	CC
cord-015021-pol2qm74	648	9	hepatic	hepatic	JJ
cord-015021-pol2qm74	648	10	clearance	clearance	NN
cord-015021-pol2qm74	648	11	function	function	NN
cord-015021-pol2qm74	648	12	of	of	IN
cord-015021-pol2qm74	648	13	bacteria	bacteria	NNS
cord-015021-pol2qm74	648	14	and	and	CC
cord-015021-pol2qm74	648	15	toxins	toxin	NNS
cord-015021-pol2qm74	648	16	can	can	MD
cord-015021-pol2qm74	648	17	be	be	VB
cord-015021-pol2qm74	648	18	observed	observe	VBN
cord-015021-pol2qm74	648	19	under	under	IN
cord-015021-pol2qm74	648	20	the	the	DT
cord-015021-pol2qm74	648	21	same	same	JJ
cord-015021-pol2qm74	648	22	conditions	condition	NNS
cord-015021-pol2qm74	648	23	which	which	WDT
cord-015021-pol2qm74	648	24	enable	enable	VBP
cord-015021-pol2qm74	648	25	bacterial	bacterial	JJ
cord-015021-pol2qm74	648	26	translocation	translocation	NN
cord-015021-pol2qm74	648	27	from	from	IN
cord-015021-pol2qm74	648	28	the	the	DT
cord-015021-pol2qm74	648	29	gut	gut	NN
cord-015021-pol2qm74	648	30	.	.	.
cord-015021-pol2qm74	649	1	In	in	IN
cord-015021-pol2qm74	649	2	order	order	NN
cord-015021-pol2qm74	649	3	to	to	TO
cord-015021-pol2qm74	649	4	evaluate	evaluate	VB
cord-015021-pol2qm74	649	5	the	the	DT
cord-015021-pol2qm74	649	6	influence	influence	NN
cord-015021-pol2qm74	649	7	of	of	IN
cord-015021-pol2qm74	649	8	circulatory	circulatory	JJ
cord-015021-pol2qm74	649	9	,	,	,
cord-015021-pol2qm74	649	10	metabolic	metabolic	JJ
cord-015021-pol2qm74	649	11	and	and	CC
cord-015021-pol2qm74	649	12	humorul	humorul	NNP
cord-015021-pol2qm74	649	13	disorders	disorder	NNS
cord-015021-pol2qm74	649	14	on	on	IN
cord-015021-pol2qm74	649	15	the	the	DT
cord-015021-pol2qm74	649	16	elimination	elimination	NN
cord-015021-pol2qm74	649	17	of	of	IN
cord-015021-pol2qm74	649	18	bacteria	bacteria	NNS
cord-015021-pol2qm74	649	19	out	out	IN
cord-015021-pol2qm74	649	20	of	of	IN
cord-015021-pol2qm74	649	21	the	the	DT
cord-015021-pol2qm74	649	22	blood	blood	NN
cord-015021-pol2qm74	649	23	circulation	circulation	NN
cord-015021-pol2qm74	649	24	,	,	,
cord-015021-pol2qm74	649	25	a	a	DT
cord-015021-pol2qm74	649	26	series	series	NN
cord-015021-pol2qm74	649	27	of	of	IN
cord-015021-pol2qm74	649	28	experiments	experiment	NNS
cord-015021-pol2qm74	649	29	were	be	VBD
cord-015021-pol2qm74	649	30	performed	perform	VBN
cord-015021-pol2qm74	649	31	in	in	IN
cord-015021-pol2qm74	649	32	anesthetized	anesthetized	JJ
cord-015021-pol2qm74	649	33	and	and	CC
cord-015021-pol2qm74	649	34	ventilated	ventilate	VBN
cord-015021-pol2qm74	649	35	rabbits	rabbit	NNS
cord-015021-pol2qm74	649	36	which	which	WDT
cord-015021-pol2qm74	649	37	received	receive	VBD
cord-015021-pol2qm74	649	38	defined	define	VBN
cord-015021-pol2qm74	649	39	numbers	number	NNS
cord-015021-pol2qm74	649	40	(	(	-LRB-
cord-015021-pol2qm74	649	41	1.3	1.3	CD
cord-015021-pol2qm74	649	42	x	x	SYM
cord-015021-pol2qm74	649	43	108	108	CD
cord-015021-pol2qm74	649	44	colony	colony	NN
cord-015021-pol2qm74	649	45	-	-	HYPH
cord-015021-pol2qm74	649	46	furming	furme	VBG
cord-015021-pol2qm74	649	47	units	unit	NNS
cord-015021-pol2qm74	649	48	)	)	-RRB-
cord-015021-pol2qm74	649	49	of	of	IN
cord-015021-pol2qm74	649	50	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	649	51	coli	coli	NNS
cord-015021-pol2qm74	649	52	as	as	IN
cord-015021-pol2qm74	649	53	a	a	DT
cord-015021-pol2qm74	649	54	bolus	bolus	NN
cord-015021-pol2qm74	649	55	injection	injection	NN
cord-015021-pol2qm74	649	56	.	.	.
cord-015021-pol2qm74	650	1	In	in	IN
cord-015021-pol2qm74	650	2	unaffected	unaffected	JJ
cord-015021-pol2qm74	650	3	control	control	NN
cord-015021-pol2qm74	650	4	animals	animal	NNS
cord-015021-pol2qm74	650	5	the	the	DT
cord-015021-pol2qm74	650	6	intravenously	intravenously	RB
cord-015021-pol2qm74	650	7	injected	inject	VBN
cord-015021-pol2qm74	650	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	650	9	are	be	VBP
cord-015021-pol2qm74	650	10	eliminated	eliminate	VBN
cord-015021-pol2qm74	650	11	about	about	RB
cord-015021-pol2qm74	650	12	99.9	99.9	CD
cord-015021-pol2qm74	650	13	%	%	NN
cord-015021-pol2qm74	650	14	within	within	IN
cord-015021-pol2qm74	650	15	the	the	DT
cord-015021-pol2qm74	650	16	first	first	JJ
cord-015021-pol2qm74	650	17	15	15	CD
cord-015021-pol2qm74	650	18	minutes	minute	NNS
cord-015021-pol2qm74	650	19	and	and	CC
cord-015021-pol2qm74	650	20	are	be	VBP
cord-015021-pol2qm74	650	21	totaiy	totaiy	VBN
cord-015021-pol2qm74	650	22	cleared	clear	VBN
cord-015021-pol2qm74	650	23	within	within	IN
cord-015021-pol2qm74	650	24	90	90	CD
cord-015021-pol2qm74	650	25	minutes	minute	NNS
cord-015021-pol2qm74	650	26	.	.	.
cord-015021-pol2qm74	651	1	57	57	CD
cord-015021-pol2qm74	651	2	%	%	NN
cord-015021-pol2qm74	651	3	offue	offue	NNP
cord-015021-pol2qm74	651	4	total	total	JJ
cord-015021-pol2qm74	651	5	CFU	CFU	NNP
cord-015021-pol2qm74	651	6	counted	count	VBD
cord-015021-pol2qm74	651	7	in	in	IN
cord-015021-pol2qm74	651	8	the	the	DT
cord-015021-pol2qm74	651	9	cultures	culture	NNS
cord-015021-pol2qm74	651	10	of	of	IN
cord-015021-pol2qm74	651	11	the	the	DT
cord-015021-pol2qm74	651	12	organ	organ	NN
cord-015021-pol2qm74	651	13	homogenates	homogenate	NNS
cord-015021-pol2qm74	651	14	were	be	VBD
cord-015021-pol2qm74	651	15	found	find	VBN
cord-015021-pol2qm74	651	16	in	in	IN
cord-015021-pol2qm74	651	17	liver	liver	NN
cord-015021-pol2qm74	651	18	and	and	CC
cord-015021-pol2qm74	651	19	spleen	spleen	NNS
cord-015021-pol2qm74	651	20	,	,	,
cord-015021-pol2qm74	651	21	whereas	whereas	IN
cord-015021-pol2qm74	651	22	only	only	RB
cord-015021-pol2qm74	651	23	very	very	RB
cord-015021-pol2qm74	651	24	low	low	JJ
cord-015021-pol2qm74	651	25	numbers	number	NNS
cord-015021-pol2qm74	651	26	could	could	MD
cord-015021-pol2qm74	651	27	be	be	VB
cord-015021-pol2qm74	651	28	detected	detect	VBN
cord-015021-pol2qm74	651	29	in	in	IN
cord-015021-pol2qm74	651	30	the	the	DT
cord-015021-pol2qm74	651	31	lungs	lung	NNS
cord-015021-pol2qm74	651	32	and	and	CC
cord-015021-pol2qm74	651	33	kidneys	kidney	NNS
cord-015021-pol2qm74	651	34	.	.	.
cord-015021-pol2qm74	652	1	Systemic	systemic	JJ
cord-015021-pol2qm74	652	2	injury	injury	NN
cord-015021-pol2qm74	652	3	of	of	IN
cord-015021-pol2qm74	652	4	the	the	DT
cord-015021-pol2qm74	652	5	animals	animal	NNS
cord-015021-pol2qm74	652	6	by	by	IN
cord-015021-pol2qm74	652	7	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	652	8	shock	shock	NN
cord-015021-pol2qm74	652	9	,	,	,
cord-015021-pol2qm74	652	10	endotoxinemia	endotoxinemia	NN
cord-015021-pol2qm74	652	11	,	,	,
cord-015021-pol2qm74	652	12	hypoxia	hypoxia	NN
cord-015021-pol2qm74	652	13	,	,	,
cord-015021-pol2qm74	652	14	coagulation	coagulation	NN
cord-015021-pol2qm74	652	15	disorder	disorder	NN
cord-015021-pol2qm74	652	16	,	,	,
cord-015021-pol2qm74	652	17	systemic	systemic	JJ
cord-015021-pol2qm74	652	18	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	652	19	by	by	IN
cord-015021-pol2qm74	652	20	norepinephrine	norepinephrine	NN
cord-015021-pol2qm74	652	21	and	and	CC
cord-015021-pol2qm74	652	22	other	other	JJ
cord-015021-pol2qm74	652	23	types	type	NNS
cord-015021-pol2qm74	652	24	of	of	IN
cord-015021-pol2qm74	652	25	injury	injury	NN
cord-015021-pol2qm74	652	26	reduced	reduce	VBD
cord-015021-pol2qm74	652	27	the	the	DT
cord-015021-pol2qm74	652	28	elimination	elimination	NN
cord-015021-pol2qm74	652	29	rate	rate	NN
cord-015021-pol2qm74	652	30	of	of	IN
cord-015021-pol2qm74	652	31	bacteria	bacteria	NNS
cord-015021-pol2qm74	652	32	and	and	CC
cord-015021-pol2qm74	652	33	changed	change	VBD
cord-015021-pol2qm74	652	34	the	the	DT
cord-015021-pol2qm74	652	35	pattern	pattern	NN
cord-015021-pol2qm74	652	36	and	and	CC
cord-015021-pol2qm74	652	37	degree	degree	NN
cord-015021-pol2qm74	652	38	of	of	IN
cord-015021-pol2qm74	652	39	their	-PRON-	PRP$
cord-015021-pol2qm74	652	40	dissemination	dissemination	NN
cord-015021-pol2qm74	652	41	and	and	CC
cord-015021-pol2qm74	652	42	tissue	tissue	NN
cord-015021-pol2qm74	652	43	distribution	distribution	NN
cord-015021-pol2qm74	652	44	.	.	.
cord-015021-pol2qm74	653	1	The	the	DT
cord-015021-pol2qm74	653	2	bacterial	bacterial	JJ
cord-015021-pol2qm74	653	3	clearance	clearance	NN
cord-015021-pol2qm74	653	4	was	be	VBD
cord-015021-pol2qm74	653	5	delayed	delay	VBN
cord-015021-pol2qm74	653	6	mostly	mostly	RB
cord-015021-pol2qm74	653	7	in	in	IN
cord-015021-pol2qm74	653	8	rabbits	rabbit	NNS
cord-015021-pol2qm74	653	9	subjected	subject	VBN
cord-015021-pol2qm74	653	10	to	to	IN
cord-015021-pol2qm74	653	11	hypoxemic	hypoxemic	JJ
cord-015021-pol2qm74	653	12	hypoxia	hypoxia	NN
cord-015021-pol2qm74	653	13	in	in	IN
cord-015021-pol2qm74	653	14	which	which	WDT
cord-015021-pol2qm74	653	15	about	about	RB
cord-015021-pol2qm74	653	16	100	100	CD
cord-015021-pol2qm74	653	17	CFU	CFU	NNS
cord-015021-pol2qm74	653	18	of	of	IN
cord-015021-pol2qm74	653	19	viable	viable	JJ
cord-015021-pol2qm74	653	20	E.eoli	E.eoli	NNS
cord-015021-pol2qm74	653	21	per	per	IN
cord-015021-pol2qm74	653	22	ml	ml	NN
cord-015021-pol2qm74	653	23	blood	blood	NN
cord-015021-pol2qm74	653	24	could	could	MD
cord-015021-pol2qm74	653	25	still	still	RB
cord-015021-pol2qm74	653	26	be	be	VB
cord-015021-pol2qm74	653	27	counted	count	VBN
cord-015021-pol2qm74	653	28	3	3	CD
cord-015021-pol2qm74	653	29	hours	hour	NNS
cord-015021-pol2qm74	653	30	following	follow	VBG
cord-015021-pol2qm74	653	31	their	-PRON-	PRP$
cord-015021-pol2qm74	653	32	injection	injection	NN
cord-015021-pol2qm74	653	33	.	.	.
cord-015021-pol2qm74	654	1	The	the	DT
cord-015021-pol2qm74	654	2	number	number	NN
cord-015021-pol2qm74	654	3	of	of	IN
cord-015021-pol2qm74	654	4	viable	viable	JJ
cord-015021-pol2qm74	654	5	bacteria	bacteria	NNS
cord-015021-pol2qm74	654	6	was	be	VBD
cord-015021-pol2qm74	654	7	some	some	DT
cord-015021-pol2qm74	654	8	ten	ten	CD
cord-015021-pol2qm74	654	9	powers	power	NNS
cord-015021-pol2qm74	654	10	higher	higher	RBR
cord-015021-pol2qm74	654	11	in	in	IN
cord-015021-pol2qm74	654	12	organs	organ	NNS
cord-015021-pol2qm74	654	13	of	of	IN
cord-015021-pol2qm74	654	14	hypoxic	hypoxic	JJ
cord-015021-pol2qm74	654	15	rabbits	rabbit	NNS
cord-015021-pol2qm74	654	16	in	in	IN
cord-015021-pol2qm74	654	17	comparison	comparison	NN
cord-015021-pol2qm74	654	18	to	to	TO
cord-015021-pol2qm74	654	19	control	control	VB
cord-015021-pol2qm74	654	20	ardmais	ardmais	NNP
cord-015021-pol2qm74	654	21	,	,	,
cord-015021-pol2qm74	654	22	and	and	CC
cord-015021-pol2qm74	654	23	an	an	DT
cord-015021-pol2qm74	654	24	excessive	excessive	JJ
cord-015021-pol2qm74	654	25	colonisation	colonisation	NN
cord-015021-pol2qm74	654	26	of	of	IN
cord-015021-pol2qm74	654	27	the	the	DT
cord-015021-pol2qm74	654	28	lungs	lung	NNS
cord-015021-pol2qm74	654	29	and	and	CC
cord-015021-pol2qm74	654	30	kidneys	kidney	NNS
cord-015021-pol2qm74	654	31	with	with	IN
cord-015021-pol2qm74	654	32	25	25	CD
cord-015021-pol2qm74	654	33	%	%	NN
cord-015021-pol2qm74	654	34	respectively	respectively	RB
cord-015021-pol2qm74	654	35	11	11	CD
cord-015021-pol2qm74	654	36	%	%	NN
cord-015021-pol2qm74	654	37	of	of	IN
cord-015021-pol2qm74	654	38	the	the	DT
cord-015021-pol2qm74	654	39	total	total	JJ
cord-015021-pol2qm74	654	40	CFU	CFU	NNP
cord-015021-pol2qm74	654	41	of	of	IN
cord-015021-pol2qm74	654	42	the	the	DT
cord-015021-pol2qm74	654	43	cultared	cultared	JJ
cord-015021-pol2qm74	654	44	organ	organ	NN
cord-015021-pol2qm74	654	45	homoganates	homoganates	NNPS
cord-015021-pol2qm74	654	46	was	be	VBD
cord-015021-pol2qm74	654	47	observed	observe	VBN
cord-015021-pol2qm74	654	48	.	.	.
cord-015021-pol2qm74	655	1	Unilateral	unilateral	JJ
cord-015021-pol2qm74	655	2	iscbemia	iscbemia	NN
cord-015021-pol2qm74	655	3	of	of	IN
cord-015021-pol2qm74	655	4	the	the	DT
cord-015021-pol2qm74	655	5	kidney	kidney	NN
cord-015021-pol2qm74	655	6	prior	prior	RB
cord-015021-pol2qm74	655	7	to	to	IN
cord-015021-pol2qm74	655	8	the	the	DT
cord-015021-pol2qm74	655	9	intravenous	intravenous	JJ
cord-015021-pol2qm74	655	10	injection	injection	NN
cord-015021-pol2qm74	655	11	of	of	IN
cord-015021-pol2qm74	655	12	E.coli	E.coli	NNS
cord-015021-pol2qm74	655	13	only	only	RB
cord-015021-pol2qm74	655	14	moderately	moderately	RB
cord-015021-pol2qm74	655	15	delayed	delay	VBD
cord-015021-pol2qm74	655	16	the	the	DT
cord-015021-pol2qm74	655	17	bacterial	bacterial	JJ
cord-015021-pol2qm74	655	18	clearance	clearance	NN
cord-015021-pol2qm74	655	19	,	,	,
cord-015021-pol2qm74	655	20	bowever	bowever	NNP
cord-015021-pol2qm74	655	21	,	,	,
cord-015021-pol2qm74	655	22	caused	cause	VBD
cord-015021-pol2qm74	655	23	an	an	DT
cord-015021-pol2qm74	655	24	intense	intense	JJ
cord-015021-pol2qm74	655	25	eohinisation	eohinisation	NN
cord-015021-pol2qm74	655	26	of	of	IN
cord-015021-pol2qm74	655	27	the	the	DT
cord-015021-pol2qm74	655	28	affected	affected	JJ
cord-015021-pol2qm74	655	29	reperfused	reperfused	JJ
cord-015021-pol2qm74	655	30	organ	organ	NN
cord-015021-pol2qm74	655	31	.	.	.
cord-015021-pol2qm74	656	1	In	in	IN
cord-015021-pol2qm74	656	2	contrast	contrast	NN
cord-015021-pol2qm74	656	3	to	to	IN
cord-015021-pol2qm74	656	4	this	this	DT
cord-015021-pol2qm74	656	5	,	,	,
cord-015021-pol2qm74	656	6	inhalation	inhalation	NN
cord-015021-pol2qm74	656	7	injury	injury	NN
cord-015021-pol2qm74	656	8	did	do	VBD
cord-015021-pol2qm74	656	9	not	not	RB
cord-015021-pol2qm74	656	10	promote	promote	VB
cord-015021-pol2qm74	656	11	the	the	DT
cord-015021-pol2qm74	656	12	accumulation	accumulation	NN
cord-015021-pol2qm74	656	13	of	of	IN
cord-015021-pol2qm74	656	14	bacteria	bacteria	NNS
cord-015021-pol2qm74	656	15	in	in	IN
cord-015021-pol2qm74	656	16	the	the	DT
cord-015021-pol2qm74	656	17	lungs	lung	NNS
cord-015021-pol2qm74	656	18	.	.	.
cord-015021-pol2qm74	657	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	657	2	:	:	:
cord-015021-pol2qm74	657	3	Shock	shock	NN
cord-015021-pol2qm74	657	4	,	,	,
cord-015021-pol2qm74	657	5	systemic	systemic	JJ
cord-015021-pol2qm74	657	6	and	and	CC
cord-015021-pol2qm74	657	7	local	local	JJ
cord-015021-pol2qm74	657	8	affections	affection	NNS
cord-015021-pol2qm74	657	9	reduce	reduce	VBP
cord-015021-pol2qm74	657	10	the	the	DT
cord-015021-pol2qm74	657	11	clearance	clearance	NN
cord-015021-pol2qm74	657	12	of	of	IN
cord-015021-pol2qm74	657	13	bacteria	bacteria	NNS
cord-015021-pol2qm74	657	14	from	from	IN
cord-015021-pol2qm74	657	15	the	the	DT
cord-015021-pol2qm74	657	16	blood	blood	NN
cord-015021-pol2qm74	657	17	circulation	circulation	NN
cord-015021-pol2qm74	657	18	and	and	CC
cord-015021-pol2qm74	657	19	enable	enable	VB
cord-015021-pol2qm74	657	20	their	-PRON-	PRP$
cord-015021-pol2qm74	657	21	dissemination	dissemination	NN
cord-015021-pol2qm74	657	22	and	and	CC
cord-015021-pol2qm74	657	23	accumulation	accumulation	NN
cord-015021-pol2qm74	657	24	in	in	IN
cord-015021-pol2qm74	657	25	vital	vital	JJ
cord-015021-pol2qm74	657	26	organs	organ	NNS
cord-015021-pol2qm74	657	27	.	.	.
cord-015021-pol2qm74	658	1	The	the	DT
cord-015021-pol2qm74	658	2	degree	degree	NN
cord-015021-pol2qm74	658	3	of	of	IN
cord-015021-pol2qm74	658	4	this	this	DT
cord-015021-pol2qm74	658	5	reduction	reduction	NN
cord-015021-pol2qm74	658	6	and	and	CC
cord-015021-pol2qm74	658	7	the	the	DT
cord-015021-pol2qm74	658	8	organ	organ	NN
cord-015021-pol2qm74	658	9	pattern	pattern	NN
cord-015021-pol2qm74	658	10	of	of	IN
cord-015021-pol2qm74	658	11	the	the	DT
cord-015021-pol2qm74	658	12	bacterial	bacterial	JJ
cord-015021-pol2qm74	658	13	distribution	distribution	NN
cord-015021-pol2qm74	658	14	varies	vary	VBZ
cord-015021-pol2qm74	658	15	with	with	IN
cord-015021-pol2qm74	658	16	the	the	DT
cord-015021-pol2qm74	658	17	type	type	NN
cord-015021-pol2qm74	658	18	of	of	IN
cord-015021-pol2qm74	658	19	injury	injury	NN
cord-015021-pol2qm74	658	20	.	.	.
cord-015021-pol2qm74	659	1	Thus	thus	RB
cord-015021-pol2qm74	659	2	,	,	,
cord-015021-pol2qm74	659	3	these	these	DT
cord-015021-pol2qm74	659	4	factors	factor	NNS
cord-015021-pol2qm74	659	5	seem	seem	VBP
cord-015021-pol2qm74	659	6	to	to	TO
cord-015021-pol2qm74	659	7	be	be	VB
cord-015021-pol2qm74	659	8	essentially	essentially	RB
cord-015021-pol2qm74	659	9	involved	involve	VBN
cord-015021-pol2qm74	659	10	whether	whether	IN
cord-015021-pol2qm74	659	11	or	or	CC
cord-015021-pol2qm74	659	12	not	not	RB
cord-015021-pol2qm74	659	13	bacterial	bacterial	JJ
cord-015021-pol2qm74	659	14	translocation	translocation	NN
cord-015021-pol2qm74	659	15	and	and	CC
cord-015021-pol2qm74	659	16	multiple	multiple	JJ
cord-015021-pol2qm74	659	17	organ	organ	NN
cord-015021-pol2qm74	659	18	failure	failure	NN
cord-015021-pol2qm74	659	19	will	will	MD
cord-015021-pol2qm74	659	20	follow	follow	VB
cord-015021-pol2qm74	659	21	the	the	DT
cord-015021-pol2qm74	659	22	invasion	invasion	NN
cord-015021-pol2qm74	659	23	of	of	IN
cord-015021-pol2qm74	659	24	bacteria	bacteria	NNS
cord-015021-pol2qm74	659	25	into	into	IN
cord-015021-pol2qm74	659	26	the	the	DT
cord-015021-pol2qm74	659	27	circulation	circulation	NN
cord-015021-pol2qm74	659	28	as	as	IN
cord-015021-pol2qm74	659	29	in	in	IN
cord-015021-pol2qm74	659	30	the	the	DT
cord-015021-pol2qm74	659	31	ease	ease	NN
cord-015021-pol2qm74	659	32	of	of	IN
cord-015021-pol2qm74	659	33	gut	gut	NN
cord-015021-pol2qm74	659	34	barrier	barrier	NN
cord-015021-pol2qm74	659	35	dysfunction	dysfunction	NN
cord-015021-pol2qm74	659	36	.	.	.
cord-015021-pol2qm74	660	1	Movement	movement	NN
cord-015021-pol2qm74	660	2	of	of	IN
cord-015021-pol2qm74	660	3	enteric	enteric	JJ
cord-015021-pol2qm74	660	4	baaterla	baaterla	NN
cord-015021-pol2qm74	660	5	from	from	IN
cord-015021-pol2qm74	660	6	gut	gut	NN
cord-015021-pol2qm74	660	7	to	to	IN
cord-015021-pol2qm74	660	8	extralumeaal	extralumeaal	NN
cord-015021-pol2qm74	660	9	sites	site	NNS
cord-015021-pol2qm74	660	10	(	(	-LRB-
cord-015021-pol2qm74	660	11	bacterial	bacterial	JJ
cord-015021-pol2qm74	660	12	tra	tra	NN
cord-015021-pol2qm74	660	13	~	~	CD
cord-015021-pol2qm74	660	14	sloeation	sloeation	NN
cord-015021-pol2qm74	660	15	)	)	-RRB-
cord-015021-pol2qm74	660	16	m	m	NNP
cord-015021-pol2qm74	660	17	~	~	NNP
cord-015021-pol2qm74	660	18	y	y	NNP
cord-015021-pol2qm74	660	19	play	play	VBP
cord-015021-pol2qm74	660	20	a	a	DT
cord-015021-pol2qm74	660	21	role	role	NN
cord-015021-pol2qm74	660	22	~.	~.	.
cord-015021-pol2qm74	661	1	nraltipl~	nraltipl~	NN
cord-015021-pol2qm74	662	1	orga~	orga~	NNP
cord-015021-pol2qm74	662	2	failure	failure	NN
cord-015021-pol2qm74	662	3	.	.	.
cord-015021-pol2qm74	663	1	Traumatic	traumatic	JJ
cord-015021-pol2qm74	663	2	stress	stress	NN
cord-015021-pol2qm74	663	3	(	(	-LRB-
cord-015021-pol2qm74	663	4	shock	shock	NN
cord-015021-pol2qm74	663	5	,	,	,
cord-015021-pol2qm74	663	6	hffectiort	hffectiort	NNP
cord-015021-pol2qm74	663	7	,	,	,
cord-015021-pol2qm74	663	8	and	and	CC
cord-015021-pol2qm74	663	9	im	im	UH
cord-015021-pol2qm74	663	10	~	~	NFP
cord-015021-pol2qm74	663	11	lammation	lammation	NN
cord-015021-pol2qm74	663	12	)	)	-RRB-
cord-015021-pol2qm74	663	13	and	and	CC
cord-015021-pol2qm74	663	14	severe	severe	JJ
cord-015021-pol2qm74	663	15	illness	illness	NN
cord-015021-pol2qm74	663	16	are	be	VBP
cord-015021-pol2qm74	663	17	common	common	JJ
cord-015021-pol2qm74	663	18	alateeedents	alateeedent	NNS
cord-015021-pol2qm74	663	19	.	.	.
cord-015021-pol2qm74	664	1	Tnt	Tnt	NNP
cord-015021-pol2qm74	665	1	~st	~st	NNP
cord-015021-pol2qm74	665	2	~	~	NFP
cord-015021-pol2qm74	665	3	aal	aal	NNP
cord-015021-pol2qm74	665	4	Lleus	Lleus	NNP
cord-015021-pol2qm74	665	5	is	be	VBZ
cord-015021-pol2qm74	665	6	e	e	DT
cord-015021-pol2qm74	665	7	common	common	JJ
cord-015021-pol2qm74	665	8	proximme	proximme	JJ
cord-015021-pol2qm74	665	9	causal	causal	JJ
cord-015021-pol2qm74	665	10	factor	factor	NN
cord-015021-pol2qm74	665	11	.	.	.
cord-015021-pol2qm74	666	1	We	-PRON-	PRP
cord-015021-pol2qm74	666	2	have	have	VBP
cord-015021-pol2qm74	666	3	exanlined	exanline	VBN
cord-015021-pol2qm74	666	4	the	the	DT
cord-015021-pol2qm74	666	5	hypothesis	hypothesis	NN
cord-015021-pol2qm74	666	6	that	that	IN
cord-015021-pol2qm74	666	7	bacterial	bacterial	JJ
cord-015021-pol2qm74	666	8	ttanslecation	ttanslecation	NN
cord-015021-pol2qm74	666	9	from	from	IN
cord-015021-pol2qm74	666	10	the	the	DT
cord-015021-pol2qm74	666	11	gut	gut	NN
cord-015021-pol2qm74	666	12	in	in	IN
cord-015021-pol2qm74	666	13	expe	expe	NNS
cord-015021-pol2qm74	666	14	~	~	NFP
cord-015021-pol2qm74	666	15	me	-PRON-	PRP
cord-015021-pol2qm74	666	16	~	~	NFP
cord-015021-pol2qm74	666	17	tal	tal	NNP
cord-015021-pol2qm74	666	18	paaerestitis	paaerestitis	NNP
cord-015021-pol2qm74	666	19	is	be	VBZ
cord-015021-pol2qm74	666	20	due	due	JJ
cord-015021-pol2qm74	666	21	to	to	IN
cord-015021-pol2qm74	666	22	bacterial	bacterial	JJ
cord-015021-pol2qm74	666	23	overgrowth	overgrowth	NN
cord-015021-pol2qm74	666	24	as	as	IN
cord-015021-pol2qm74	666	25	a	a	DT
cord-015021-pol2qm74	666	26	cuas	cua	NNS
cord-015021-pol2qm74	666	27	~	~	NFP
cord-015021-pol2qm74	666	28	ucnee	ucnee	NN
cord-015021-pol2qm74	666	29	of	of	IN
cord-015021-pol2qm74	666	30	a	a	DT
cord-015021-pol2qm74	666	31	deere	deere	NNP
cord-015021-pol2qm74	666	32	~	~	NFP
cord-015021-pol2qm74	666	33	ae	ae	NNP
cord-015021-pol2qm74	666	34	in	in	IN
cord-015021-pol2qm74	666	35	intestinal	intestinal	JJ
cord-015021-pol2qm74	666	36	transit	transit	NN
cord-015021-pol2qm74	666	37	.	.	.
cord-015021-pol2qm74	667	1	Ne	Ne	NNP
cord-015021-pol2qm74	668	1	~rotiT_.~g	~rotiT_.~g	NFP
cord-015021-pol2qm74	669	1	pancreatitls	pancreatitls	NNP
cord-015021-pol2qm74	669	2	fblIowlng	fblIowlng	.
cord-015021-pol2qm74	670	1	bile	bile	NN
cord-015021-pol2qm74	670	2	duct	duct	NN
cord-015021-pol2qm74	670	3	iigation	iigation	NN
cord-015021-pol2qm74	670	4	in	in	IN
cord-015021-pol2qm74	670	5	the	the	DT
cord-015021-pol2qm74	670	6	opossum	opossum	NN
cord-015021-pol2qm74	670	7	is	be	VBZ
cord-015021-pol2qm74	670	8	associated	associate	VBN
cord-015021-pol2qm74	670	9	with	with	IN
cord-015021-pol2qm74	670	10	colonization	colonization	NN
cord-015021-pol2qm74	670	11	of	of	IN
cord-015021-pol2qm74	670	12	the	the	DT
cord-015021-pol2qm74	670	13	pa	pa	NNP
cord-015021-pol2qm74	670	14	,	,	,
cord-015021-pol2qm74	670	15	se	se	NNP
cord-015021-pol2qm74	670	16	~re	~re	NNP
cord-015021-pol2qm74	670	17	,	,	,
cord-015021-pol2qm74	670	18	aa	aa	NNP
cord-015021-pol2qm74	670	19	by	by	IN
cord-015021-pol2qm74	670	20	gut	gut	NN
cord-015021-pol2qm74	670	21	derived	derive	VBN
cord-015021-pol2qm74	670	22	organisms	organism	NNS
cord-015021-pol2qm74	670	23	or	or	CC
cord-015021-pol2qm74	670	24	salmonella	salmonella	NN
cord-015021-pol2qm74	670	25	of	of	IN
cord-015021-pol2qm74	670	26	bilJary	biljary	JJ
cord-015021-pol2qm74	670	27	origin	origin	NN
cord-015021-pol2qm74	670	28	in	in	IN
cord-015021-pol2qm74	670	29	infected	infected	JJ
cord-015021-pol2qm74	670	30	animals	animal	NNS
cord-015021-pol2qm74	670	31	(	(	-LRB-
cord-015021-pol2qm74	670	32	previously	previously	RB
cord-015021-pol2qm74	670	33	reported	report	VBN
cord-015021-pol2qm74	670	34	)	)	-RRB-
cord-015021-pol2qm74	670	35	.	.	.
cord-015021-pol2qm74	671	1	To	to	IN
cord-015021-pol2qm74	671	2	ti	ti	NNP
cord-015021-pol2qm74	671	3	~	~	NNP
cord-015021-pol2qm74	671	4	rther	rther	NNP
cord-015021-pol2qm74	671	5	define	define	VBP
cord-015021-pol2qm74	671	6	the	the	DT
cord-015021-pol2qm74	671	7	mechanism	mechanism	NN
cord-015021-pol2qm74	671	8	of	of	IN
cord-015021-pol2qm74	671	9	transloemdon	transloemdon	NN
cord-015021-pol2qm74	671	10	in	in	IN
cord-015021-pol2qm74	671	11	panereati	panereati	NNP
cord-015021-pol2qm74	671	12	*	*	NFP
cord-015021-pol2qm74	672	1	inflammation	inflammation	NN
cord-015021-pol2qm74	673	1	,	,	,
cord-015021-pol2qm74	673	2	pancteatitis	pancteatitis	NNP
cord-015021-pol2qm74	673	3	was	be	VBD
cord-015021-pol2qm74	673	4	induced	induce	VBN
cord-015021-pol2qm74	673	5	hy	hy	NNP
cord-015021-pol2qm74	673	6	iigatlon	iigatlon	NNP
cord-015021-pol2qm74	673	7	of	of	IN
cord-015021-pol2qm74	673	8	t	t	NNP
cord-015021-pol2qm74	673	9	~	~	NFP
cord-015021-pol2qm74	673	10	e	e	XX
cord-015021-pol2qm74	673	11	lower	low	JJR
cord-015021-pol2qm74	673	12	bile	bile	NN
cord-015021-pol2qm74	673	13	duet	duet	NN
cord-015021-pol2qm74	673	14	distal	distal	IN
cord-015021-pol2qm74	673	15	to	to	IN
cord-015021-pol2qm74	673	16	the	the	DT
cord-015021-pol2qm74	673	17	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	673	18	duets	duet	NNS
cord-015021-pol2qm74	673	19	m	m	VBP
cord-015021-pol2qm74	673	20	the	the	DT
cord-015021-pol2qm74	673	21	rat	rat	NN
cord-015021-pol2qm74	673	22	.	.	.
cord-015021-pol2qm74	674	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	674	2	transit	transit	NN
cord-015021-pol2qm74	674	3	,	,	,
cord-015021-pol2qm74	674	4	enteric	enteric	JJ
cord-015021-pol2qm74	674	5	bacteriology	bacteriology	NN
cord-015021-pol2qm74	674	6	,	,	,
cord-015021-pol2qm74	674	7	and	and	CC
cord-015021-pol2qm74	674	8	tromsloeatien	tromsloeatien	NNP
cord-015021-pol2qm74	674	9	of	of	IN
cord-015021-pol2qm74	674	10	bacteria	bacteria	NNS
cord-015021-pol2qm74	674	11	to	to	IN
cord-015021-pol2qm74	674	12	mesanterie	mesanterie	NNP
cord-015021-pol2qm74	674	13	lymph	lymph	NN
cord-015021-pol2qm74	674	14	nodes	node	NNS
cord-015021-pol2qm74	674	15	,	,	,
cord-015021-pol2qm74	674	16	blood	blood	NN
cord-015021-pol2qm74	674	17	stream	stream	NN
cord-015021-pol2qm74	674	18	and	and	CC
cord-015021-pol2qm74	674	19	splanelmie	splanelmie	NNP
cord-015021-pol2qm74	674	20	organs	organ	NNS
cord-015021-pol2qm74	675	1	wen	wen	NNP
cord-015021-pol2qm74	675	2	deletmhaed	deletmhaed	NNP
cord-015021-pol2qm74	675	3	at	at	IN
cord-015021-pol2qm74	675	4	24	24	CD
cord-015021-pol2qm74	675	5	(	(	-LRB-
cord-015021-pol2qm74	675	6	n~	n~	NNP
cord-015021-pol2qm74	675	7	7	7	CD
cord-015021-pol2qm74	675	8	)	)	-RRB-
cord-015021-pol2qm74	675	9	,	,	,
cord-015021-pol2qm74	675	10	4	4	CD
cord-015021-pol2qm74	675	11	g	g	NN
cord-015021-pol2qm74	675	12	(	(	-LRB-
cord-015021-pol2qm74	675	13	n	n	NN
cord-015021-pol2qm74	675	14	~	~	CD
cord-015021-pol2qm74	675	15	10	10	CD
cord-015021-pol2qm74	675	16	)	)	-RRB-
cord-015021-pol2qm74	675	17	,	,	,
cord-015021-pol2qm74	675	18	and	and	CC
cord-015021-pol2qm74	675	19	96	96	CD
cord-015021-pol2qm74	676	1	(	(	-LRB-
cord-015021-pol2qm74	676	2	n~	n~	$
cord-015021-pol2qm74	676	3	10	10	CD
cord-015021-pol2qm74	676	4	)	)	-RRB-
cord-015021-pol2qm74	676	5	hours	hour	NNS
cord-015021-pol2qm74	676	6	with	with	IN
cord-015021-pol2qm74	676	7	the	the	DT
cord-015021-pol2qm74	676	8	fallowing	fallowe	VBG
cord-015021-pol2qm74	676	9	results	result	NNS
cord-015021-pol2qm74	676	10	:	:	:
cord-015021-pol2qm74	676	11	lY	ly	XX
cord-015021-pol2qm74	676	12	~	~	NFP
cord-015021-pol2qm74	676	13	TESTINAI,	testinai,	CD
cord-015021-pol2qm74	676	14	..	..	.
cord-015021-pol2qm74	676	15	TRANSFI	TRANSFI	NNP
cord-015021-pol2qm74	676	16	"	"	''
cord-015021-pol2qm74	676	17	.	.	.
cord-015021-pol2qm74	677	1	Geometric	geometric	JJ
cord-015021-pol2qm74	677	2	Mean	Mean	NNP
cord-015021-pol2qm74	677	3	of	of	IN
cord-015021-pol2qm74	677	4	Fluorescent	Fluorescent	NNP
cord-015021-pol2qm74	677	5	Marker	Marker	NNP
cord-015021-pol2qm74	677	6	-25	-25	''
cord-015021-pol2qm74	677	7	%	%	NN
cord-015021-pol2qm74	677	8	at	at	IN
cord-015021-pol2qm74	677	9	24	24	CD
cord-015021-pol2qm74	677	10	hour~	hour~	NN
cord-015021-pol2qm74	677	11	with	with	IN
cord-015021-pol2qm74	677	12	return	return	NN
cord-015021-pol2qm74	677	13	to	to	IN
cord-015021-pol2qm74	677	14	51	51	CD
cord-015021-pol2qm74	677	15	%	%	NN
cord-015021-pol2qm74	677	16	of	of	IN
cord-015021-pol2qm74	677	17	gut	gut	NN
cord-015021-pol2qm74	677	18	leugth	leugth	NNP
cord-015021-pol2qm74	677	19	(	(	-LRB-
cord-015021-pol2qm74	677	20	similar	similar	JJ
cord-015021-pol2qm74	677	21	to	to	IN
cord-015021-pol2qm74	677	22	~m	~m	NNP
cord-015021-pol2qm74	677	23	)	)	-RRB-
cord-015021-pol2qm74	678	1	at	at	IN
cord-015021-pol2qm74	678	2	96	96	CD
cord-015021-pol2qm74	678	3	hour~.	hour~.	ADD
cord-015021-pol2qm74	678	4	BACTERIAL	BACTERIAL	NNP
cord-015021-pol2qm74	678	5	OVERGROWT_Hff	OVERGROWT_Hff	NNPS
cord-015021-pol2qm74	678	6	-Increase	-Increase	:
cord-015021-pol2qm74	678	7	in	in	IN
cord-015021-pol2qm74	678	8	total	total	JJ
cord-015021-pol2qm74	678	9	bsctetia	bsctetia	NN
cord-015021-pol2qm74	679	1	~ad	~ad	NNP
cord-015021-pol2qm74	679	2	gram	gram	NN
cord-015021-pol2qm74	679	3	negative	negative	JJ
cord-015021-pol2qm74	679	4	rod.~	rod.~	NNS
cord-015021-pol2qm74	679	5	at	at	IN
cord-015021-pol2qm74	679	6	2	2	CD
cord-015021-pol2qm74	679	7	,	,	,
cord-015021-pol2qm74	679	8	;	;	:
cord-015021-pol2qm74	679	9	hours	hour	NNS
cord-015021-pol2qm74	679	10	with	with	IN
cord-015021-pol2qm74	679	11	return	return	NN
cord-015021-pol2qm74	679	12	to	to	IN
cord-015021-pol2qm74	679	13	sham	sham	JJ
cord-015021-pol2qm74	679	14	control	control	NN
cord-015021-pol2qm74	679	15	at	at	IN
cord-015021-pol2qm74	679	16	96	96	CD
cord-015021-pol2qm74	679	17	hours	hour	NNS
cord-015021-pol2qm74	679	18	(	(	-LRB-
cord-015021-pol2qm74	679	19	9	9	CD
cord-015021-pol2qm74	679	20	Log	Log	NNP
cord-015021-pol2qm74	679	21	CFU	CFU	NNP
cord-015021-pol2qm74	679	22	/	/	SYM
cord-015021-pol2qm74	679	23	g	g	NN
cord-015021-pol2qm74	679	24	veraus	veraus	NNP
cord-015021-pol2qm74	679	25	6	6	CD
cord-015021-pol2qm74	679	26	Log	Log	NNP
cord-015021-pol2qm74	679	27	CFU	CFU	NNP
cord-015021-pol2qm74	679	28	/	/	SYM
cord-015021-pol2qm74	679	29	g	g	NNP
cord-015021-pol2qm74	679	30	ia	ia	NNP
cord-015021-pol2qm74	679	31	ileum	ileum	NNP
cord-015021-pol2qm74	679	32	)	)	-RRB-
cord-015021-pol2qm74	679	33	.	.	.
cord-015021-pol2qm74	680	1	TRANSLOCATION	TRANSLOCATION	NNP
cord-015021-pol2qm74	680	2	TO	to	IN
cord-015021-pol2qm74	680	3	MESENTERIC	MESENTERIC	NNP
cord-015021-pol2qm74	680	4	NODES	node	NNS
cord-015021-pol2qm74	680	5	-71	-71	VBG
cord-015021-pol2qm74	680	6	,	,	,
cord-015021-pol2qm74	680	7	90	90	CD
cord-015021-pol2qm74	680	8	,	,	,
cord-015021-pol2qm74	680	9	and	and	CC
cord-015021-pol2qm74	680	10	30	30	CD
cord-015021-pol2qm74	680	11	percent	percent	NN
cord-015021-pol2qm74	680	12	at	at	IN
cord-015021-pol2qm74	680	13	24	24	CD
cord-015021-pol2qm74	680	14	,	,	,
cord-015021-pol2qm74	680	15	48	48	CD
cord-015021-pol2qm74	680	16	,	,	,
cord-015021-pol2qm74	680	17	and	and	CC
cord-015021-pol2qm74	680	18	9fi	9fi	CD
cord-015021-pol2qm74	680	19	hours	hour	NNS
cord-015021-pol2qm74	680	20	compared	compare	VBN
cord-015021-pol2qm74	680	21	to	to	IN
cord-015021-pol2qm74	680	22	49b	49b	CD
cord-015021-pol2qm74	680	23	in	in	IN
cord-015021-pol2qm74	680	24	sham	sham	NN
cord-015021-pol2qm74	680	25	controls	control	NNS
cord-015021-pol2qm74	680	26	(	(	-LRB-
cord-015021-pol2qm74	680	27	n	n	NN
cord-015021-pol2qm74	680	28	=	=	SYM
cord-015021-pol2qm74	680	29	l	l	NN
cord-015021-pol2qm74	680	30	of	of	IN
cord-015021-pol2qm74	680	31	26	26	CD
cord-015021-pol2qm74	680	32	)	)	-RRB-
cord-015021-pol2qm74	680	33	.	.	.
cord-015021-pol2qm74	681	1	CONCLUSION	conclusion	JJ
cord-015021-pol2qm74	681	2	-Bacterial	-bacterial	JJ
cord-015021-pol2qm74	681	3	translocation	translocation	NN
cord-015021-pol2qm74	681	4	following	follow	VBG
cord-015021-pol2qm74	681	5	panetoatieobiliary	panetoatieobiliary	NN
cord-015021-pol2qm74	681	6	duct	duct	NN
cord-015021-pol2qm74	681	7	lJgation	lJgation	NNP
cord-015021-pol2qm74	681	8	induced	induce	VBN
cord-015021-pol2qm74	681	9	panereatitls	panereatitls	NNP
cord-015021-pol2qm74	681	10	ha	ha	UH
cord-015021-pol2qm74	681	11	the	the	DT
cord-015021-pol2qm74	681	12	rat	rat	NN
cord-015021-pol2qm74	681	13	is	be	VBZ
cord-015021-pol2qm74	681	14	tighlly	tighlly	RB
cord-015021-pol2qm74	681	15	linked	link	VBN
cord-015021-pol2qm74	681	16	to	to	IN
cord-015021-pol2qm74	681	17	intestinal	intestinal	JJ
cord-015021-pol2qm74	681	18	trausit	trausit	NN
cord-015021-pol2qm74	681	19	and	and	CC
cord-015021-pol2qm74	681	20	bacterial	bacterial	JJ
cord-015021-pol2qm74	681	21	overgrowth	overgrowth	NN
cord-015021-pol2qm74	681	22	within	within	IN
cord-015021-pol2qm74	681	23	the	the	DT
cord-015021-pol2qm74	681	24	gut	gut	NN
cord-015021-pol2qm74	681	25	lumen	lumen	NN
cord-015021-pol2qm74	681	26	.	.	.
cord-015021-pol2qm74	682	1	SPECLrJLATION	speclrjlation	CD
cord-015021-pol2qm74	683	1	-The	-the	WDT
cord-015021-pol2qm74	683	2	ilens	ilen	NNS
cord-015021-pol2qm74	683	3	in	in	IN
cord-015021-pol2qm74	683	4	in/~aRm	in/~aRm	NNP
cord-015021-pol2qm74	684	1	~ation	~ation	NNP
cord-015021-pol2qm74	684	2	may	may	MD
cord-015021-pol2qm74	684	3	be	be	VB
cord-015021-pol2qm74	684	4	related	relate	VBN
cord-015021-pol2qm74	684	5	to	to	IN
cord-015021-pol2qm74	684	6	activation	activation	NN
cord-015021-pol2qm74	684	7	of	of	IN
cord-015021-pol2qm74	684	8	eytokiaes	eytokiae	NNS
cord-015021-pol2qm74	684	9	and	and	CC
cord-015021-pol2qm74	684	10	mediated	mediate	VBN
cord-015021-pol2qm74	684	11	by	by	IN
cord-015021-pol2qm74	684	12	nitric	nitric	NN
cord-015021-pol2qm74	684	13	oxide	oxide	NN
cord-015021-pol2qm74	684	14	.	.	.
cord-015021-pol2qm74	685	1	Preliminary	preliminary	JJ
cord-015021-pol2qm74	685	2	evidence	evidence	NN
cord-015021-pol2qm74	685	3	for	for	IN
cord-015021-pol2qm74	685	4	this	this	DT
cord-015021-pol2qm74	685	5	notion	notion	NN
cord-015021-pol2qm74	685	6	will	will	MD
cord-015021-pol2qm74	685	7	be	be	VB
cord-015021-pol2qm74	685	8	discussed	discuss	VBN
cord-015021-pol2qm74	685	9	.	.	.
cord-015021-pol2qm74	686	1	In	in	IN
cord-015021-pol2qm74	686	2	a	a	DT
cord-015021-pol2qm74	686	3	series	series	NN
cord-015021-pol2qm74	686	4	of	of	IN
cord-015021-pol2qm74	686	5	studies	study	NNS
cord-015021-pol2qm74	686	6	we	-PRON-	PRP
cord-015021-pol2qm74	686	7	investigated	investigate	VBD
cord-015021-pol2qm74	686	8	:	:	:
cord-015021-pol2qm74	686	9	a	a	LS
cord-015021-pol2qm74	686	10	)	)	-RRB-
cord-015021-pol2qm74	686	11	the	the	DT
cord-015021-pol2qm74	686	12	time	time	NN
cord-015021-pol2qm74	686	13	course	course	NN
cord-015021-pol2qm74	686	14	of	of	IN
cord-015021-pol2qm74	686	15	bacterial	bacterial	JJ
cord-015021-pol2qm74	686	16	translocation	translocation	NN
cord-015021-pol2qm74	686	17	(	(	-LRB-
cord-015021-pol2qm74	686	18	BT	BT	NNP
cord-015021-pol2qm74	686	19	)	)	-RRB-
cord-015021-pol2qm74	686	20	,	,	,
cord-015021-pol2qm74	686	21	b	b	LS
cord-015021-pol2qm74	686	22	)	)	-RRB-
cord-015021-pol2qm74	686	23	the	the	DT
cord-015021-pol2qm74	686	24	kinetics	kinetic	NNS
cord-015021-pol2qm74	686	25	of	of	IN
cord-015021-pol2qm74	686	26	LPS	LPS	NNP
cord-015021-pol2qm74	686	27	and	and	CC
cord-015021-pol2qm74	686	28	cytokine	cytokine	NN
cord-015021-pol2qm74	686	29	appearance	appearance	NN
cord-015021-pol2qm74	686	30	(	(	-LRB-
cord-015021-pol2qm74	686	31	TNF	TNF	NNP
cord-015021-pol2qm74	686	32	,	,	,
cord-015021-pol2qm74	686	33	IL-6	IL-6	NNP
cord-015021-pol2qm74	686	34	,	,	,
cord-015021-pol2qm74	686	35	Soluble	Soluble	NNP
cord-015021-pol2qm74	686	36	TNF	TNF	NNP
cord-015021-pol2qm74	686	37	receptor	receptor	NN
cord-015021-pol2qm74	686	38	[	[	-LRB-
cord-015021-pol2qm74	686	39	sTNF	stnf	NN
cord-015021-pol2qm74	686	40	-	-	HYPH
cord-015021-pol2qm74	686	41	R	r	NN
cord-015021-pol2qm74	686	42	]	]	-RRB-
cord-015021-pol2qm74	686	43	)	)	-RRB-
cord-015021-pol2qm74	686	44	in	in	IN
cord-015021-pol2qm74	686	45	the	the	DT
cord-015021-pol2qm74	686	46	circulation	circulation	NN
cord-015021-pol2qm74	686	47	,	,	,
cord-015021-pol2qm74	686	48	and	and	CC
cord-015021-pol2qm74	686	49	c	c	LS
cord-015021-pol2qm74	686	50	)	)	-RRB-
cord-015021-pol2qm74	686	51	the	the	DT
cord-015021-pol2qm74	686	52	role	role	NN
cord-015021-pol2qm74	686	53	of	of	IN
cord-015021-pol2qm74	686	54	LPS	LPS	NNP
cord-015021-pol2qm74	686	55	and/or	and/or	CC
cord-015021-pol2qm74	686	56	TNF	TNF	NNP
cord-015021-pol2qm74	686	57	with	with	IN
cord-015021-pol2qm74	686	58	regard	regard	NN
cord-015021-pol2qm74	686	59	to	to	IN
cord-015021-pol2qm74	686	60	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	686	61	shock	shock	NN
cord-015021-pol2qm74	686	62	(	(	-LRB-
cord-015021-pol2qm74	686	63	HS	HS	NNP
cord-015021-pol2qm74	686	64	)	)	-RRB-
cord-015021-pol2qm74	686	65	related	relate	VBN
cord-015021-pol2qm74	686	66	pathophysiologie	pathophysiologie	NN
cord-015021-pol2qm74	686	67	alterations	alteration	NNS
cord-015021-pol2qm74	686	68	and	and	CC
cord-015021-pol2qm74	686	69	mortality	mortality	NN
cord-015021-pol2qm74	686	70	in	in	IN
cord-015021-pol2qm74	686	71	baboons	baboon	NNS
cord-015021-pol2qm74	686	72	and/or	and/or	CC
cord-015021-pol2qm74	686	73	rats	rat	NNS
cord-015021-pol2qm74	686	74	.	.	.
cord-015021-pol2qm74	687	1	Method	method	NN
cord-015021-pol2qm74	687	2	:	:	:
cord-015021-pol2qm74	688	1	Baboons	baboon	NNS
cord-015021-pol2qm74	688	2	were	be	VBD
cord-015021-pol2qm74	688	3	subjected	subject	VBN
cord-015021-pol2qm74	688	4	to	to	IN
cord-015021-pol2qm74	688	5	femur	femur	NN
cord-015021-pol2qm74	688	6	fracture	fracture	NN
cord-015021-pol2qm74	688	7	,	,	,
cord-015021-pol2qm74	688	8	soft	soft	JJ
cord-015021-pol2qm74	688	9	tissue	tissue	NN
cord-015021-pol2qm74	688	10	trauma	trauma	NN
cord-015021-pol2qm74	688	11	(	(	-LRB-
cord-015021-pol2qm74	688	12	acute	acute	JJ
cord-015021-pol2qm74	688	13	experiment	experiment	NN
cord-015021-pol2qm74	688	14	)	)	-RRB-
cord-015021-pol2qm74	688	15	,	,	,
cord-015021-pol2qm74	688	16	and	and	CC
cord-015021-pol2qm74	688	17	HS	HS	NNP
cord-015021-pol2qm74	688	18	(	(	-LRB-
cord-015021-pol2qm74	688	19	40	40	CD
cord-015021-pol2qm74	688	20	mmHg	mmHg	NNS
cord-015021-pol2qm74	688	21	mean	mean	VBP
cord-015021-pol2qm74	688	22	arterial	arterial	JJ
cord-015021-pol2qm74	688	23	pressure	pressure	NN
cord-015021-pol2qm74	688	24	:	:	:
cord-015021-pol2qm74	688	25	MAP	map	VB
cord-015021-pol2qm74	688	26	for	for	IN
cord-015021-pol2qm74	688	27	2	2	CD
cord-015021-pol2qm74	688	28	-	-	SYM
cord-015021-pol2qm74	688	29	4	4	CD
cord-015021-pol2qm74	688	30	h	h	NN
cord-015021-pol2qm74	688	31	terminated	terminate	VBD
cord-015021-pol2qm74	688	32	at	at	IN
cord-015021-pol2qm74	688	33	an	an	DT
cord-015021-pol2qm74	688	34	accumulated	accumulate	VBN
cord-015021-pol2qm74	688	35	oxygen	oxygen	NN
cord-015021-pol2qm74	688	36	debt	debt	NN
cord-015021-pol2qm74	688	37	of	of	IN
cord-015021-pol2qm74	688	38	180	180	CD
cord-015021-pol2qm74	688	39	-	-	SYM
cord-015021-pol2qm74	688	40	200	200	CD
cord-015021-pol2qm74	688	41	ml	ml	NNS
cord-015021-pol2qm74	688	42	/	/	SYM
cord-015021-pol2qm74	688	43	kg	kg	NNS
cord-015021-pol2qm74	688	44	followed	follow	VBN
cord-015021-pol2qm74	688	45	by	by	IN
cord-015021-pol2qm74	688	46	resuscitation	resuscitation	NN
cord-015021-pol2qm74	688	47	)	)	-RRB-
cord-015021-pol2qm74	688	48	.	.	.
cord-015021-pol2qm74	689	1	A	a	DT
cord-015021-pol2qm74	689	2	chronic	chronic	JJ
cord-015021-pol2qm74	689	3	model	model	NN
cord-015021-pol2qm74	689	4	of	of	IN
cord-015021-pol2qm74	689	5	HS	HS	NNP
cord-015021-pol2qm74	689	6	was	be	VBD
cord-015021-pol2qm74	689	7	set	set	VBN
cord-015021-pol2qm74	689	8	up	up	RP
cord-015021-pol2qm74	689	9	by	by	IN
cord-015021-pol2qm74	689	10	administration	administration	NN
cord-015021-pol2qm74	689	11	of	of	IN
cord-015021-pol2qm74	689	12	zymosan	zymosan	NNP
cord-015021-pol2qm74	689	13	activated	activated	NNP
cord-015021-pol2qm74	689	14	plasma	plasma	NN
cord-015021-pol2qm74	689	15	(	(	-LRB-
cord-015021-pol2qm74	689	16	ZAP	ZAP	NNP
cord-015021-pol2qm74	689	17	)	)	-RRB-
cord-015021-pol2qm74	689	18	before	before	IN
cord-015021-pol2qm74	689	19	and	and	CC
cord-015021-pol2qm74	689	20	after	after	IN
cord-015021-pol2qm74	689	21	HS	HS	NNP
cord-015021-pol2qm74	689	22	but	but	CC
cord-015021-pol2qm74	689	23	without	without	IN
cord-015021-pol2qm74	689	24	trauma	trauma	NN
cord-015021-pol2qm74	689	25	.	.	.
cord-015021-pol2qm74	690	1	HS	HS	NNP
cord-015021-pol2qm74	690	2	was	be	VBD
cord-015021-pol2qm74	690	3	induced	induce	VBN
cord-015021-pol2qm74	690	4	in	in	IN
cord-015021-pol2qm74	690	5	rats	rat	NNS
cord-015021-pol2qm74	690	6	by	by	IN
cord-015021-pol2qm74	690	7	bleeding	bleed	VBG
cord-015021-pol2qm74	690	8	the	the	DT
cord-015021-pol2qm74	690	9	animals	animal	NNS
cord-015021-pol2qm74	690	10	to	to	IN
cord-015021-pol2qm74	690	11	MAP	MAP	NNP
cord-015021-pol2qm74	690	12	of	of	IN
cord-015021-pol2qm74	690	13	30	30	CD
cord-015021-pol2qm74	690	14	-	-	SYM
cord-015021-pol2qm74	690	15	35	35	CD
cord-015021-pol2qm74	690	16	mmHg	mmHg	NNS
cord-015021-pol2qm74	690	17	90	90	CD
cord-015021-pol2qm74	690	18	-	-	SYM
cord-015021-pol2qm74	690	19	180	180	CD
cord-015021-pol2qm74	690	20	rain	rain	NN
cord-015021-pol2qm74	690	21	followed	follow	VBN
cord-015021-pol2qm74	690	22	by	by	IN
cord-015021-pol2qm74	690	23	resuscitation	resuscitation	NN
cord-015021-pol2qm74	690	24	.	.	.
cord-015021-pol2qm74	691	1	Results	result	NNS
cord-015021-pol2qm74	691	2	and	and	CC
cord-015021-pol2qm74	691	3	conclusion	conclusion	NN
cord-015021-pol2qm74	691	4	:	:	:
cord-015021-pol2qm74	691	5	In	in	IN
cord-015021-pol2qm74	691	6	rats	rat	NNS
cord-015021-pol2qm74	691	7	,	,	,
cord-015021-pol2qm74	691	8	LPS	LPS	NNP
cord-015021-pol2qm74	691	9	increased	increase	VBD
cord-015021-pol2qm74	691	10	in	in	IN
cord-015021-pol2qm74	691	11	the	the	DT
cord-015021-pol2qm74	691	12	systemic	systemic	JJ
cord-015021-pol2qm74	691	13	circulation	circulation	NN
cord-015021-pol2qm74	691	14	,	,	,
cord-015021-pol2qm74	691	15	plasma	plasma	NN
cord-015021-pol2qm74	691	16	TNF	TNF	NNP
cord-015021-pol2qm74	691	17	levels	level	NNS
cord-015021-pol2qm74	691	18	were	be	VBD
cord-015021-pol2qm74	691	19	found	find	VBN
cord-015021-pol2qm74	691	20	to	to	TO
cord-015021-pol2qm74	691	21	be	be	VB
cord-015021-pol2qm74	691	22	significantly	significantly	RB
cord-015021-pol2qm74	691	23	elevated	elevate	VBN
cord-015021-pol2qm74	691	24	at	at	IN
cord-015021-pol2qm74	691	25	90	90	CD
cord-015021-pol2qm74	691	26	min	min	NN
cord-015021-pol2qm74	691	27	and	and	CC
cord-015021-pol2qm74	691	28	were	be	VBD
cord-015021-pol2qm74	691	29	still	still	RB
cord-015021-pol2qm74	691	30	markedly	markedly	RB
cord-015021-pol2qm74	691	31	increased	increase	VBN
cord-015021-pol2qm74	691	32	at	at	IN
cord-015021-pol2qm74	691	33	150	150	CD
cord-015021-pol2qm74	691	34	rain	rain	NN
cord-015021-pol2qm74	691	35	postshock	postshock	NN
cord-015021-pol2qm74	691	36	.	.	.
cord-015021-pol2qm74	692	1	Plasma	Plasma	NNP
cord-015021-pol2qm74	692	2	TNF	TNF	NNP
cord-015021-pol2qm74	692	3	,	,	,
cord-015021-pol2qm74	692	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	692	5	,	,	,
cord-015021-pol2qm74	692	6	and	and	CC
cord-015021-pol2qm74	692	7	sTNF	stnf	NN
cord-015021-pol2qm74	692	8	-	-	HYPH
cord-015021-pol2qm74	692	9	R	r	NN
cord-015021-pol2qm74	692	10	levels	level	NNS
cord-015021-pol2qm74	692	11	increased	increase	VBD
cord-015021-pol2qm74	692	12	already	already	RB
cord-015021-pol2qm74	692	13	during	during	IN
cord-015021-pol2qm74	692	14	the	the	DT
cord-015021-pol2qm74	692	15	shock	shock	NN
cord-015021-pol2qm74	692	16	period	period	NN
cord-015021-pol2qm74	692	17	in	in	IN
cord-015021-pol2qm74	692	18	baboons	baboon	NNS
cord-015021-pol2qm74	692	19	,	,	,
cord-015021-pol2qm74	692	20	while	while	IN
cord-015021-pol2qm74	692	21	TNF	TNF	NNP
cord-015021-pol2qm74	692	22	was	be	VBD
cord-015021-pol2qm74	692	23	not	not	RB
cord-015021-pol2qm74	692	24	detectable	detectable	JJ
cord-015021-pol2qm74	692	25	.	.	.
cord-015021-pol2qm74	693	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	693	2	data	datum	NNS
cord-015021-pol2qm74	693	3	suggest	suggest	VBP
cord-015021-pol2qm74	693	4	that	that	IN
cord-015021-pol2qm74	693	5	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	693	6	shock	shock	NN
cord-015021-pol2qm74	693	7	may	may	MD
cord-015021-pol2qm74	693	8	lead	lead	VB
cord-015021-pol2qm74	693	9	to	to	IN
cord-015021-pol2qm74	693	10	early	early	JJ
cord-015021-pol2qm74	693	11	BT	BT	NNP
cord-015021-pol2qm74	693	12	in	in	IN
cord-015021-pol2qm74	693	13	the	the	DT
cord-015021-pol2qm74	693	14	intestinal	intestinal	JJ
cord-015021-pol2qm74	693	15	wall	wall	NN
cord-015021-pol2qm74	693	16	(	(	-LRB-
cord-015021-pol2qm74	693	17	at	at	IN
cord-015021-pol2qm74	693	18	30	30	CD
cord-015021-pol2qm74	693	19	min	min	NN
cord-015021-pol2qm74	693	20	following	follow	VBG
cord-015021-pol2qm74	693	21	resuscitation	resuscitation	NN
cord-015021-pol2qm74	693	22	in	in	IN
cord-015021-pol2qm74	693	23	rats	rat	NNS
cord-015021-pol2qm74	693	24	subjected	subject	VBN
cord-015021-pol2qm74	693	25	to	to	IN
cord-015021-pol2qm74	693	26	HS	HS	NNP
cord-015021-pol2qm74	693	27	for	for	IN
cord-015021-pol2qm74	693	28	90	90	CD
cord-015021-pol2qm74	693	29	min	min	NN
cord-015021-pol2qm74	693	30	,	,	,
cord-015021-pol2qm74	693	31	similarly	similarly	RB
cord-015021-pol2qm74	693	32	at	at	IN
cord-015021-pol2qm74	693	33	3	3	CD
cord-015021-pol2qm74	693	34	h	h	NN
cord-015021-pol2qm74	693	35	after	after	IN
cord-015021-pol2qm74	693	36	the	the	DT
cord-015021-pol2qm74	693	37	end	end	NN
cord-015021-pol2qm74	693	38	of	of	IN
cord-015021-pol2qm74	693	39	oxygen	oxygen	NN
cord-015021-pol2qm74	693	40	debt	debt	NN
cord-015021-pol2qm74	693	41	period	period	NN
cord-015021-pol2qm74	693	42	in	in	IN
cord-015021-pol2qm74	693	43	baboons	baboon	NNS
cord-015021-pol2qm74	693	44	)	)	-RRB-
cord-015021-pol2qm74	693	45	and	and	CC
cord-015021-pol2qm74	693	46	transient	transient	JJ
cord-015021-pol2qm74	693	47	access	access	NN
cord-015021-pol2qm74	693	48	of	of	IN
cord-015021-pol2qm74	693	49	gut	gut	NN
cord-015021-pol2qm74	693	50	-	-	HYPH
cord-015021-pol2qm74	693	51	derived	derive	VBN
cord-015021-pol2qm74	693	52	LPS	LPS	NNP
cord-015021-pol2qm74	693	53	into	into	IN
cord-015021-pol2qm74	693	54	the	the	DT
cord-015021-pol2qm74	693	55	circulation	circulation	NN
cord-015021-pol2qm74	693	56	(	(	-LRB-
cord-015021-pol2qm74	693	57	levels	level	NNS
cord-015021-pol2qm74	693	58	became	become	VBD
cord-015021-pol2qm74	693	59	significant	significant	JJ
cord-015021-pol2qm74	693	60	at	at	IN
cord-015021-pol2qm74	693	61	120	120	CD
cord-015021-pol2qm74	693	62	min	min	NN
cord-015021-pol2qm74	693	63	,	,	,
cord-015021-pol2qm74	693	64	while	while	IN
cord-015021-pol2qm74	693	65	in	in	IN
cord-015021-pol2qm74	693	66	baboons	baboon	NNS
cord-015021-pol2qm74	693	67	higher	high	JJR
cord-015021-pol2qm74	693	68	levels	level	NNS
cord-015021-pol2qm74	693	69	up	up	IN
cord-015021-pol2qm74	693	70	to	to	IN
cord-015021-pol2qm74	693	71	300	300	CD
cord-015021-pol2qm74	693	72	pg	pg	NN
cord-015021-pol2qm74	693	73	/	/	SYM
cord-015021-pol2qm74	693	74	ml	ml	NNS
cord-015021-pol2qm74	693	75	were	be	VBD
cord-015021-pol2qm74	693	76	found	find	VBN
cord-015021-pol2qm74	693	77	at	at	IN
cord-015021-pol2qm74	693	78	the	the	DT
cord-015021-pol2qm74	693	79	end	end	NN
cord-015021-pol2qm74	693	80	of	of	IN
cord-015021-pol2qm74	693	81	shock	shock	NN
cord-015021-pol2qm74	693	82	and	and	CC
cord-015021-pol2qm74	693	83	1	1	CD
cord-015021-pol2qm74	693	84	h	h	NN
cord-015021-pol2qm74	693	85	after	after	IN
cord-015021-pol2qm74	693	86	reinfusion	reinfusion	NN
cord-015021-pol2qm74	693	87	,	,	,
cord-015021-pol2qm74	693	88	partially	partially	RB
cord-015021-pol2qm74	693	89	accompanied	accompany	VBN
cord-015021-pol2qm74	693	90	by	by	IN
cord-015021-pol2qm74	693	91	bacteremia	bacteremia	NN
cord-015021-pol2qm74	693	92	)	)	-RRB-
cord-015021-pol2qm74	693	93	.	.	.
cord-015021-pol2qm74	694	1	In	in	IN
cord-015021-pol2qm74	694	2	addition	addition	NN
cord-015021-pol2qm74	694	3	,	,	,
cord-015021-pol2qm74	694	4	since	since	IN
cord-015021-pol2qm74	694	5	the	the	DT
cord-015021-pol2qm74	694	6	treatment	treatment	NN
cord-015021-pol2qm74	694	7	of	of	IN
cord-015021-pol2qm74	694	8	rats	rat	NNS
cord-015021-pol2qm74	694	9	with	with	IN
cord-015021-pol2qm74	694	10	anti	anti	JJ
cord-015021-pol2qm74	694	11	LPS	LPS	NNP
cord-015021-pol2qm74	694	12	measures	measure	NNS
cord-015021-pol2qm74	694	13	or	or	CC
cord-015021-pol2qm74	694	14	anti	anti	NNP
cord-015021-pol2qm74	694	15	TNF	TNF	NNP
cord-015021-pol2qm74	694	16	therapy	therapy	NN
cord-015021-pol2qm74	694	17	significantly	significantly	RB
cord-015021-pol2qm74	694	18	improved	improve	VBD
cord-015021-pol2qm74	694	19	the	the	DT
cord-015021-pol2qm74	694	20	48-hour	48-hour	JJ
cord-015021-pol2qm74	694	21	survival	survival	NN
cord-015021-pol2qm74	694	22	rate	rate	NN
cord-015021-pol2qm74	694	23	it	-PRON-	PRP
cord-015021-pol2qm74	694	24	can	can	MD
cord-015021-pol2qm74	694	25	be	be	VB
cord-015021-pol2qm74	694	26	assumed	assume	VBN
cord-015021-pol2qm74	694	27	that	that	IN
cord-015021-pol2qm74	694	28	endogenous	endogenous	JJ
cord-015021-pol2qm74	694	29	LPS	LPS	NNP
cord-015021-pol2qm74	694	30	and	and	CC
cord-015021-pol2qm74	694	31	LPS	LPS	NNP
cord-015021-pol2qm74	694	32	-	-	HYPH
cord-015021-pol2qm74	694	33	induced	induce	VBN
cord-015021-pol2qm74	694	34	mediator(s	mediator(s	NNP
cord-015021-pol2qm74	694	35	)	)	-RRB-
cord-015021-pol2qm74	694	36	,	,	,
cord-015021-pol2qm74	694	37	in	in	IN
cord-015021-pol2qm74	694	38	particular	particular	JJ
cord-015021-pol2qm74	694	39	TNF	TNF	NNP
cord-015021-pol2qm74	694	40	,	,	,
cord-015021-pol2qm74	694	41	may	may	MD
cord-015021-pol2qm74	694	42	lead	lead	VB
cord-015021-pol2qm74	694	43	to	to	IN
cord-015021-pol2qm74	694	44	organ	organ	NN
cord-015021-pol2qm74	694	45	injury	injury	NN
cord-015021-pol2qm74	694	46	and	and	CC
cord-015021-pol2qm74	694	47	mortality	mortality	NN
cord-015021-pol2qm74	694	48	following	follow	VBG
cord-015021-pol2qm74	694	49	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	694	50	shock	shock	NN
cord-015021-pol2qm74	694	51	.	.	.
cord-015021-pol2qm74	695	1	Alteration	alteration	NN
cord-015021-pol2qm74	695	2	of	of	IN
cord-015021-pol2qm74	695	3	the	the	DT
cord-015021-pol2qm74	695	4	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	695	5	blood	blood	NN
cord-015021-pol2qm74	695	6	flow	flow	NN
cord-015021-pol2qm74	695	7	and	and	CC
cord-015021-pol2qm74	695	8	the	the	DT
cord-015021-pol2qm74	695	9	consequent	consequent	JJ
cord-015021-pol2qm74	695	10	ischemia	ischemia	NN
cord-015021-pol2qm74	695	11	/	/	SYM
cord-015021-pol2qm74	695	12	reperfusion	reperfusion	NN
cord-015021-pol2qm74	695	13	injury	injury	NN
cord-015021-pol2qm74	695	14	to	to	IN
cord-015021-pol2qm74	695	15	the	the	DT
cord-015021-pol2qm74	695	16	intestine	intestine	NN
cord-015021-pol2qm74	695	17	appear	appear	VB
cord-015021-pol2qm74	695	18	to	to	TO
cord-015021-pol2qm74	695	19	be	be	VB
cord-015021-pol2qm74	695	20	one	one	CD
cord-015021-pol2qm74	695	21	of	of	IN
cord-015021-pol2qm74	695	22	the	the	DT
cord-015021-pol2qm74	695	23	earliest	early	JJS
cord-015021-pol2qm74	695	24	events	event	NNS
cord-015021-pol2qm74	695	25	in	in	IN
cord-015021-pol2qm74	695	26	the	the	DT
cord-015021-pol2qm74	695	27	systemic	systemic	JJ
cord-015021-pol2qm74	695	28	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	695	29	response	response	NN
cord-015021-pol2qm74	695	30	following	follow	VBG
cord-015021-pol2qm74	695	31	severe	severe	JJ
cord-015021-pol2qm74	695	32	thermal	thermal	JJ
cord-015021-pol2qm74	695	33	injuries	injury	NNS
cord-015021-pol2qm74	695	34	.	.	.
cord-015021-pol2qm74	696	1	The	the	DT
cord-015021-pol2qm74	696	2	causative	causative	JJ
cord-015021-pol2qm74	696	3	relationship	relationship	NN
cord-015021-pol2qm74	696	4	between	between	IN
cord-015021-pol2qm74	696	5	the	the	DT
cord-015021-pol2qm74	696	6	subsequent	subsequent	JJ
cord-015021-pol2qm74	696	7	disruption	disruption	NN
cord-015021-pol2qm74	696	8	of	of	IN
cord-015021-pol2qm74	696	9	the	the	DT
cord-015021-pol2qm74	696	10	intestinal	intestinal	JJ
cord-015021-pol2qm74	696	11	integrity	integrity	NN
cord-015021-pol2qm74	696	12	and	and	CC
cord-015021-pol2qm74	696	13	the	the	DT
cord-015021-pol2qm74	696	14	potentiation	potentiation	NN
cord-015021-pol2qm74	696	15	of	of	IN
cord-015021-pol2qm74	696	16	the	the	DT
cord-015021-pol2qm74	696	17	translocation	translocation	NN
cord-015021-pol2qm74	696	18	of	of	IN
cord-015021-pol2qm74	696	19	indigenous	indigenous	JJ
cord-015021-pol2qm74	696	20	bacteria	bacteria	NNS
cord-015021-pol2qm74	696	21	and/or	and/or	CC
cord-015021-pol2qm74	696	22	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	696	23	to	to	IN
cord-015021-pol2qm74	696	24	remote	remote	JJ
cord-015021-pol2qm74	696	25	body	body	NN
cord-015021-pol2qm74	696	26	organs	organ	NNS
cord-015021-pol2qm74	696	27	and	and	CC
cord-015021-pol2qm74	696	28	the	the	DT
cord-015021-pol2qm74	696	29	systemic	systemic	JJ
cord-015021-pol2qm74	696	30	circulation	circulation	NN
cord-015021-pol2qm74	696	31	has	have	VBZ
cord-015021-pol2qm74	696	32	been	be	VBN
cord-015021-pol2qm74	696	33	deeumented	deeumente	VBN
cord-015021-pol2qm74	696	34	in	in	IN
cord-015021-pol2qm74	696	35	several	several	JJ
cord-015021-pol2qm74	696	36	studies	study	NNS
cord-015021-pol2qm74	696	37	.	.	.
cord-015021-pol2qm74	697	1	Among	among	IN
cord-015021-pol2qm74	697	2	other	other	JJ
cord-015021-pol2qm74	697	3	effects	effect	NNS
cord-015021-pol2qm74	697	4	,	,	,
cord-015021-pol2qm74	697	5	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	697	6	solely	solely	RB
cord-015021-pol2qm74	697	7	or	or	CC
cord-015021-pol2qm74	697	8	acting	act	VBG
cord-015021-pol2qm74	697	9	synergistically	synergistically	RB
cord-015021-pol2qm74	697	10	with	with	IN
cord-015021-pol2qm74	697	11	thermal	thermal	JJ
cord-015021-pol2qm74	697	12	injuries	injury	NNS
cord-015021-pol2qm74	697	13	has	have	VBZ
cord-015021-pol2qm74	697	14	been	be	VBN
cord-015021-pol2qm74	697	15	shown	show	VBN
cord-015021-pol2qm74	697	16	to	to	TO
cord-015021-pol2qm74	697	17	promote	promote	VB
cord-015021-pol2qm74	697	18	bacterial	bacterial	JJ
cord-015021-pol2qm74	697	19	translocation	translocation	NN
cord-015021-pol2qm74	697	20	.	.	.
cord-015021-pol2qm74	698	1	As	as	IN
cord-015021-pol2qm74	698	2	these	these	DT
cord-015021-pol2qm74	698	3	sequences	sequence	NNS
cord-015021-pol2qm74	698	4	continue	continue	VBP
cord-015021-pol2qm74	698	5	without	without	IN
cord-015021-pol2qm74	698	6	adequate	adequate	JJ
cord-015021-pol2qm74	698	7	intervention	intervention	NN
cord-015021-pol2qm74	698	8	,	,	,
cord-015021-pol2qm74	698	9	multiple	multiple	JJ
cord-015021-pol2qm74	698	10	organ	organ	NN
cord-015021-pol2qm74	698	11	failure	failure	NN
cord-015021-pol2qm74	698	12	and	and	CC
cord-015021-pol2qm74	698	13	eventually	eventually	RB
cord-015021-pol2qm74	698	14	death	death	NN
cord-015021-pol2qm74	698	15	may	may	MD
cord-015021-pol2qm74	698	16	become	become	VB
cord-015021-pol2qm74	698	17	inevitable	inevitable	JJ
cord-015021-pol2qm74	698	18	.	.	.
cord-015021-pol2qm74	699	1	Hence	hence	RB
cord-015021-pol2qm74	699	2	,	,	,
cord-015021-pol2qm74	699	3	the	the	DT
cord-015021-pol2qm74	699	4	crucial	crucial	JJ
cord-015021-pol2qm74	699	5	need	need	NN
cord-015021-pol2qm74	699	6	of	of	IN
cord-015021-pol2qm74	699	7	treatment	treatment	NN
cord-015021-pol2qm74	699	8	modalities	modality	NNS
cord-015021-pol2qm74	699	9	with	with	IN
cord-015021-pol2qm74	699	10	the	the	DT
cord-015021-pol2qm74	699	11	capacity	capacity	NN
cord-015021-pol2qm74	699	12	of	of	IN
cord-015021-pol2qm74	699	13	modulating	modulate	VBG
cord-015021-pol2qm74	699	14	the	the	DT
cord-015021-pol2qm74	699	15	intestinal	intestinal	JJ
cord-015021-pol2qm74	699	16	blood	blood	NN
cord-015021-pol2qm74	699	17	flow	flow	NN
cord-015021-pol2qm74	699	18	and	and	CC
cord-015021-pol2qm74	699	19	preventing	prevent	VBG
cord-015021-pol2qm74	699	20	the	the	DT
cord-015021-pol2qm74	699	21	manifestations	manifestation	NNS
cord-015021-pol2qm74	699	22	of	of	IN
cord-015021-pol2qm74	699	23	these	these	DT
cord-015021-pol2qm74	699	24	pathological	pathological	JJ
cord-015021-pol2qm74	699	25	incidents	incident	NNS
cord-015021-pol2qm74	699	26	.	.	.
cord-015021-pol2qm74	700	1	Although	although	IN
cord-015021-pol2qm74	700	2	the	the	DT
cord-015021-pol2qm74	700	3	underlying	underlie	VBG
cord-015021-pol2qm74	700	4	mechanisms	mechanism	NNS
cord-015021-pol2qm74	700	5	of	of	IN
cord-015021-pol2qm74	700	6	this	this	DT
cord-015021-pol2qm74	700	7	process	process	NN
cord-015021-pol2qm74	700	8	have	have	VBP
cord-015021-pol2qm74	700	9	not	not	RB
cord-015021-pol2qm74	700	10	yet	yet	RB
cord-015021-pol2qm74	700	11	been	be	VBN
cord-015021-pol2qm74	700	12	fully	fully	RB
cord-015021-pol2qm74	700	13	elucidated	elucidate	VBN
cord-015021-pol2qm74	700	14	,	,	,
cord-015021-pol2qm74	700	15	there	there	EX
cord-015021-pol2qm74	700	16	is	be	VBZ
cord-015021-pol2qm74	700	17	accumulating	accumulate	VBG
cord-015021-pol2qm74	700	18	evidence	evidence	NN
cord-015021-pol2qm74	700	19	that	that	IN
cord-015021-pol2qm74	700	20	various	various	JJ
cord-015021-pol2qm74	700	21	interacting	interact	VBG
cord-015021-pol2qm74	700	22	vasomediators	vasomediator	NNS
cord-015021-pol2qm74	700	23	are	be	VBP
cord-015021-pol2qm74	700	24	involved	involve	VBN
cord-015021-pol2qm74	700	25	.	.	.
cord-015021-pol2qm74	701	1	The	the	DT
cord-015021-pol2qm74	701	2	actions	action	NNS
cord-015021-pol2qm74	701	3	of	of	IN
cord-015021-pol2qm74	701	4	these	these	DT
cord-015021-pol2qm74	701	5	mediators	mediator	NNS
cord-015021-pol2qm74	701	6	can	can	MD
cord-015021-pol2qm74	701	7	probably	probably	RB
cord-015021-pol2qm74	701	8	be	be	VB
cord-015021-pol2qm74	701	9	modulated	modulate	VBN
cord-015021-pol2qm74	701	10	by	by	IN
cord-015021-pol2qm74	701	11	either	either	DT
cord-015021-pol2qm74	701	12	nonspecific	nonspecific	JJ
cord-015021-pol2qm74	701	13	or	or	CC
cord-015021-pol2qm74	701	14	selective	selective	JJ
cord-015021-pol2qm74	701	15	agents	agent	NNS
cord-015021-pol2qm74	701	16	.	.	.
cord-015021-pol2qm74	702	1	Among	among	IN
cord-015021-pol2qm74	702	2	the	the	DT
cord-015021-pol2qm74	702	3	nonspecific	nonspecific	JJ
cord-015021-pol2qm74	702	4	agents	agent	NNS
cord-015021-pol2qm74	702	5	,	,	,
cord-015021-pol2qm74	702	6	the	the	DT
cord-015021-pol2qm74	702	7	composition	composition	NN
cord-015021-pol2qm74	702	8	,	,	,
cord-015021-pol2qm74	702	9	volume	volume	NN
cord-015021-pol2qm74	702	10	and	and	CC
cord-015021-pol2qm74	702	11	timing	timing	NN
cord-015021-pol2qm74	702	12	of	of	IN
cord-015021-pol2qm74	702	13	the	the	DT
cord-015021-pol2qm74	702	14	resuscitation	resuscitation	NN
cord-015021-pol2qm74	702	15	fluids	fluid	NNS
cord-015021-pol2qm74	702	16	appear	appear	VBP
cord-015021-pol2qm74	702	17	to	to	TO
cord-015021-pol2qm74	702	18	play	play	VB
cord-015021-pol2qm74	702	19	an	an	DT
cord-015021-pol2qm74	702	20	important	important	JJ
cord-015021-pol2qm74	702	21	role	role	NN
cord-015021-pol2qm74	702	22	in	in	IN
cord-015021-pol2qm74	702	23	this	this	DT
cord-015021-pol2qm74	702	24	process	process	NN
cord-015021-pol2qm74	702	25	.	.	.
cord-015021-pol2qm74	703	1	Nitropmsside	Nitropmsside	NNP
cord-015021-pol2qm74	703	2	,	,	,
cord-015021-pol2qm74	703	3	a	a	DT
cord-015021-pol2qm74	703	4	nonspecific	nonspecific	JJ
cord-015021-pol2qm74	703	5	vasodilator	vasodilator	NN
cord-015021-pol2qm74	703	6	,	,	,
cord-015021-pol2qm74	703	7	has	have	VBZ
cord-015021-pol2qm74	703	8	been	be	VBN
cord-015021-pol2qm74	703	9	shown	show	VBN
cord-015021-pol2qm74	703	10	to	to	TO
cord-015021-pol2qm74	703	11	prevent	prevent	VB
cord-015021-pol2qm74	703	12	the	the	DT
cord-015021-pol2qm74	703	13	decrease	decrease	NN
cord-015021-pol2qm74	703	14	of	of	IN
cord-015021-pol2qm74	703	15	the	the	DT
cord-015021-pol2qm74	703	16	postbum	postbum	JJ
cord-015021-pol2qm74	703	17	mesentefic	mesentefic	NNP
cord-015021-pol2qm74	703	18	blood	blood	NN
cord-015021-pol2qm74	703	19	flow	flow	NN
cord-015021-pol2qm74	703	20	when	when	WRB
cord-015021-pol2qm74	703	21	selectively	selectively	RB
cord-015021-pol2qm74	703	22	infused	infuse	VBN
cord-015021-pol2qm74	703	23	in	in	IN
cord-015021-pol2qm74	703	24	the	the	DT
cord-015021-pol2qm74	703	25	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	703	26	artery	artery	NN
cord-015021-pol2qm74	703	27	.	.	.
cord-015021-pol2qm74	704	1	The	the	DT
cord-015021-pol2qm74	704	2	nonspecificity	nonspecificity	NN
cord-015021-pol2qm74	704	3	of	of	IN
cord-015021-pol2qm74	704	4	various	various	JJ
cord-015021-pol2qm74	704	5	vasodialators	vasodialator	NNS
cord-015021-pol2qm74	704	6	with	with	IN
cord-015021-pol2qm74	704	7	their	-PRON-	PRP$
cord-015021-pol2qm74	704	8	possible	possible	JJ
cord-015021-pol2qm74	704	9	undesirable	undesirable	JJ
cord-015021-pol2qm74	704	10	systemic	systemic	JJ
cord-015021-pol2qm74	704	11	effects	effect	NNS
cord-015021-pol2qm74	704	12	emphasizes	emphasize	VBZ
cord-015021-pol2qm74	704	13	the	the	DT
cord-015021-pol2qm74	704	14	importance	importance	NN
cord-015021-pol2qm74	704	15	of	of	IN
cord-015021-pol2qm74	704	16	the	the	DT
cord-015021-pol2qm74	704	17	identification	identification	NN
cord-015021-pol2qm74	704	18	and	and	CC
cord-015021-pol2qm74	704	19	modulation	modulation	NN
cord-015021-pol2qm74	704	20	of	of	IN
cord-015021-pol2qm74	704	21	selective	selective	JJ
cord-015021-pol2qm74	704	22	vasomNiiators	vasomniiator	NNS
cord-015021-pol2qm74	704	23	.	.	.
cord-015021-pol2qm74	705	1	Thromboxane	Thromboxane	NNP
cord-015021-pol2qm74	705	2	A2	A2	NNP
cord-015021-pol2qm74	705	3	(	(	-LRB-
cord-015021-pol2qm74	705	4	TxA2	TxA2	NNP
cord-015021-pol2qm74	705	5	)	)	-RRB-
cord-015021-pol2qm74	705	6	and	and	CC
cord-015021-pol2qm74	705	7	angiotensin	angiotensin	NN
cord-015021-pol2qm74	705	8	II	II	NNP
cord-015021-pol2qm74	705	9	(	(	-LRB-
cord-015021-pol2qm74	705	10	A	A	NNP
cord-015021-pol2qm74	705	11	-	-	HYPH
cord-015021-pol2qm74	705	12	II	II	NNP
cord-015021-pol2qm74	705	13	)	)	-RRB-
cord-015021-pol2qm74	705	14	appear	appear	VBP
cord-015021-pol2qm74	705	15	to	to	TO
cord-015021-pol2qm74	705	16	be	be	VB
cord-015021-pol2qm74	705	17	the	the	DT
cord-015021-pol2qm74	705	18	primary	primary	JJ
cord-015021-pol2qm74	705	19	mediators	mediator	NNS
cord-015021-pol2qm74	705	20	of	of	IN
cord-015021-pol2qm74	705	21	the	the	DT
cord-015021-pol2qm74	705	22	postburn	postburn	NN
cord-015021-pol2qm74	705	23	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	705	24	.	.	.
cord-015021-pol2qm74	706	1	Both	both	DT
cord-015021-pol2qm74	706	2	mediators	mediator	NNS
cord-015021-pol2qm74	706	3	were	be	VBD
cord-015021-pol2qm74	706	4	found	find	VBN
cord-015021-pol2qm74	706	5	to	to	TO
cord-015021-pol2qm74	706	6	be	be	VB
cord-015021-pol2qm74	706	7	elevated	elevate	VBN
cord-015021-pol2qm74	706	8	following	following	JJ
cord-015021-pol2qm74	706	9	thermal	thermal	JJ
cord-015021-pol2qm74	706	10	injuries	injury	NNS
cord-015021-pol2qm74	706	11	.	.	.
cord-015021-pol2qm74	707	1	In	in	IN
cord-015021-pol2qm74	707	2	a	a	DT
cord-015021-pol2qm74	707	3	previous	previous	JJ
cord-015021-pol2qm74	707	4	study	study	NN
cord-015021-pol2qm74	707	5	,	,	,
cord-015021-pol2qm74	707	6	pretreatment	pretreatment	NN
cord-015021-pol2qm74	707	7	with	with	IN
cord-015021-pol2qm74	707	8	OKY-046	OKY-046	NNP
cord-015021-pol2qm74	707	9	,	,	,
cord-015021-pol2qm74	708	1	a	a	DT
cord-015021-pol2qm74	708	2	thromboxane	thromboxane	NN
cord-015021-pol2qm74	708	3	synthetese	synthetese	NN
cord-015021-pol2qm74	708	4	inhibitor	inhibitor	NN
cord-015021-pol2qm74	708	5	was	be	VBD
cord-015021-pol2qm74	708	6	found	find	VBN
cord-015021-pol2qm74	708	7	to	to	TO
cord-015021-pol2qm74	708	8	attenuate	attenuate	VB
cord-015021-pol2qm74	708	9	the	the	DT
cord-015021-pol2qm74	708	10	postbarn	postbarn	NN
cord-015021-pol2qm74	708	11	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	708	12	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	708	13	.	.	.
cord-015021-pol2qm74	709	1	In	in	IN
cord-015021-pol2qm74	709	2	a	a	DT
cord-015021-pol2qm74	709	3	bum	bum	NN
cord-015021-pol2qm74	709	4	/	/	SYM
cord-015021-pol2qm74	709	5	sepsis	sepsis	NN
cord-015021-pol2qm74	709	6	porcine	porcine	JJ
cord-015021-pol2qm74	709	7	model	model	NN
cord-015021-pol2qm74	709	8	the	the	DT
cord-015021-pol2qm74	709	9	efficacy	efficacy	NN
cord-015021-pol2qm74	709	10	of	of	IN
cord-015021-pol2qm74	709	11	DuP753	DuP753	NNP
cord-015021-pol2qm74	709	12	,	,	,
cord-015021-pol2qm74	709	13	an	an	DT
cord-015021-pol2qm74	709	14	A-11	A-11	NNP
cord-015021-pol2qm74	709	15	receptor	receptor	NN
cord-015021-pol2qm74	709	16	antagonist	antagonist	NN
cord-015021-pol2qm74	709	17	as	as	IN
cord-015021-pol2qm74	709	18	a	a	DT
cord-015021-pol2qm74	709	19	posthum	posthum	JJ
cord-015021-pol2qm74	709	20	treatment	treatment	NN
cord-015021-pol2qm74	709	21	modality	modality	NN
cord-015021-pol2qm74	709	22	was	be	VBD
cord-015021-pol2qm74	709	23	evaluated	evaluate	VBN
cord-015021-pol2qm74	709	24	.	.	.
cord-015021-pol2qm74	710	1	Treatment	treatment	NN
cord-015021-pol2qm74	710	2	with	with	IN
cord-015021-pol2qm74	710	3	DuP753	DuP753	NNS
cord-015021-pol2qm74	710	4	prevented	prevent	VBN
cord-015021-pol2qm74	710	5	the	the	DT
cord-015021-pol2qm74	710	6	early	early	JJ
cord-015021-pol2qm74	710	7	posthum	posthum	NN
cord-015021-pol2qm74	710	8	and	and	CC
cord-015021-pol2qm74	710	9	the	the	DT
cord-015021-pol2qm74	710	10	late	late	JJ
cord-015021-pol2qm74	710	11	posteodotoxin	posteodotoxin	JJ
cord-015021-pol2qm74	710	12	elevation	elevation	NN
cord-015021-pol2qm74	710	13	in	in	IN
cord-015021-pol2qm74	710	14	the	the	DT
cord-015021-pol2qm74	710	15	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	710	16	vascular	vascular	JJ
cord-015021-pol2qm74	710	17	resistance	resistance	NN
cord-015021-pol2qm74	710	18	and	and	CC
cord-015021-pol2qm74	710	19	subsequently	subsequently	RB
cord-015021-pol2qm74	710	20	abrogated	abrogate	VBD
cord-015021-pol2qm74	710	21	the	the	DT
cord-015021-pol2qm74	710	22	fall	fall	NN
cord-015021-pol2qm74	710	23	in	in	IN
cord-015021-pol2qm74	710	24	the	the	DT
cord-015021-pol2qm74	710	25	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	710	26	blood	blood	NN
cord-015021-pol2qm74	710	27	flow	flow	NN
cord-015021-pol2qm74	710	28	.	.	.
cord-015021-pol2qm74	711	1	The	the	DT
cord-015021-pol2qm74	711	2	incidence	incidence	NN
cord-015021-pol2qm74	711	3	of	of	IN
cord-015021-pol2qm74	711	4	burn	burn	NN
cord-015021-pol2qm74	711	5	&	&	CC
cord-015021-pol2qm74	711	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	711	7	induced	induce	VBN
cord-015021-pol2qm74	711	8	bacterial	bacterial	JJ
cord-015021-pol2qm74	711	9	translocation	translocation	NN
cord-015021-pol2qm74	711	10	was	be	VBD
cord-015021-pol2qm74	711	11	significantly	significantly	RB
cord-015021-pol2qm74	711	12	reduced	reduce	VBN
cord-015021-pol2qm74	711	13	by	by	IN
cord-015021-pol2qm74	711	14	DuP753	DuP753	NNS
cord-015021-pol2qm74	711	15	from	from	IN
cord-015021-pol2qm74	711	16	86	86	CD
cord-015021-pol2qm74	711	17	%	%	NN
cord-015021-pol2qm74	711	18	to	to	TO
cord-015021-pol2qm74	711	19	29	29	CD
cord-015021-pol2qm74	711	20	%	%	NN
cord-015021-pol2qm74	711	21	(	(	-LRB-
cord-015021-pol2qm74	711	22	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	711	23	,	,	,
cord-015021-pol2qm74	711	24	Fisher	Fisher	NNP
cord-015021-pol2qm74	711	25	's	's	POS
cord-015021-pol2qm74	711	26	exact	exact	JJ
cord-015021-pol2qm74	711	27	test	test	NN
cord-015021-pol2qm74	711	28	)	)	-RRB-
cord-015021-pol2qm74	711	29	.	.	.
cord-015021-pol2qm74	712	1	The	the	DT
cord-015021-pol2qm74	712	2	indigenous	indigenous	JJ
cord-015021-pol2qm74	712	3	flora	flora	NNS
cord-015021-pol2qm74	712	4	of	of	IN
cord-015021-pol2qm74	712	5	the	the	DT
cord-015021-pol2qm74	712	6	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	712	7	tract	tract	NN
cord-015021-pol2qm74	712	8	exerts	exert	VBZ
cord-015021-pol2qm74	712	9	a	a	DT
cord-015021-pol2qm74	712	10	potent	potent	JJ
cord-015021-pol2qm74	712	11	influence	influence	NN
cord-015021-pol2qm74	712	12	on	on	IN
cord-015021-pol2qm74	712	13	the	the	DT
cord-015021-pol2qm74	712	14	developmental	developmental	JJ
cord-015021-pol2qm74	712	15	maturation	maturation	NN
cord-015021-pol2qm74	712	16	of	of	IN
cord-015021-pol2qm74	712	17	normal	normal	JJ
cord-015021-pol2qm74	712	18	systemic	systemic	JJ
cord-015021-pol2qm74	712	19	immunologic	immunologic	JJ
cord-015021-pol2qm74	712	20	responsiveness	responsiveness	NN
cord-015021-pol2qm74	712	21	.	.	.
cord-015021-pol2qm74	713	1	Moreover	moreover	RB
cord-015021-pol2qm74	713	2	,	,	,
cord-015021-pol2qm74	713	3	both	both	CC
cord-015021-pol2qm74	713	4	oral	oral	JJ
cord-015021-pol2qm74	713	5	and	and	CC
cord-015021-pol2qm74	713	6	intraportal	intraportal	NNP
cord-015021-pol2qm74	713	7	administration	administration	NNP
cord-015021-pol2qm74	713	8	of	of	IN
cord-015021-pol2qm74	713	9	experimental	experimental	JJ
cord-015021-pol2qm74	713	10	antigen	antigen	NN
cord-015021-pol2qm74	713	11	is	be	VBZ
cord-015021-pol2qm74	713	12	associated	associate	VBN
cord-015021-pol2qm74	713	13	with	with	IN
cord-015021-pol2qm74	713	14	a	a	DT
cord-015021-pol2qm74	713	15	systemic	systemic	JJ
cord-015021-pol2qm74	713	16	state	state	NN
cord-015021-pol2qm74	713	17	of	of	IN
cord-015021-pol2qm74	713	18	immunologic	immunologic	JJ
cord-015021-pol2qm74	713	19	hyporesponsiveness	hyporesponsiveness	NN
cord-015021-pol2qm74	713	20	,	,	,
cord-015021-pol2qm74	713	21	known	know	VBN
cord-015021-pol2qm74	713	22	as	as	IN
cord-015021-pol2qm74	713	23	oral	oral	JJ
cord-015021-pol2qm74	713	24	tolerance	tolerance	NN
cord-015021-pol2qm74	713	25	.	.	.
cord-015021-pol2qm74	714	1	Since	since	IN
cord-015021-pol2qm74	714	2	trauma	trauma	NN
cord-015021-pol2qm74	714	3	and	and	CC
cord-015021-pol2qm74	714	4	critical	critical	JJ
cord-015021-pol2qm74	714	5	illness	illness	NN
cord-015021-pol2qm74	714	6	are	be	VBP
cord-015021-pol2qm74	714	7	associated	associate	VBN
cord-015021-pol2qm74	714	8	with	with	IN
cord-015021-pol2qm74	714	9	changes	change	NNS
cord-015021-pol2qm74	714	10	in	in	IN
cord-015021-pol2qm74	714	11	the	the	DT
cord-015021-pol2qm74	714	12	flora	flora	NNS
cord-015021-pol2qm74	714	13	of	of	IN
cord-015021-pol2qm74	714	14	the	the	DT
cord-015021-pol2qm74	714	15	gut	gut	NN
cord-015021-pol2qm74	714	16	and	and	CC
cord-015021-pol2qm74	714	17	with	with	IN
cord-015021-pol2qm74	714	18	altered	altered	JJ
cord-015021-pol2qm74	714	19	systemic	systemic	JJ
cord-015021-pol2qm74	714	20	immune	immune	JJ
cord-015021-pol2qm74	714	21	reactivity	reactivity	NN
cord-015021-pol2qm74	714	22	,	,	,
cord-015021-pol2qm74	714	23	we	-PRON-	PRP
cord-015021-pol2qm74	714	24	have	have	VBP
cord-015021-pol2qm74	714	25	hypothesized	hypothesize	VBN
cord-015021-pol2qm74	714	26	that	that	IN
cord-015021-pol2qm74	714	27	the	the	DT
cord-015021-pol2qm74	714	28	interactions	interaction	NNS
cord-015021-pol2qm74	714	29	of	of	IN
cord-015021-pol2qm74	714	30	an	an	DT
cord-015021-pol2qm74	714	31	altered	altered	JJ
cord-015021-pol2qm74	714	32	gut	gut	NN
cord-015021-pol2qm74	714	33	flora	flora	NNS
cord-015021-pol2qm74	714	34	with	with	IN
cord-015021-pol2qm74	714	35	immune	immune	JJ
cord-015021-pol2qm74	714	36	tissues	tissue	NNS
cord-015021-pol2qm74	714	37	in	in	IN
cord-015021-pol2qm74	714	38	the	the	DT
cord-015021-pol2qm74	714	39	gut	gut	NN
cord-015021-pol2qm74	714	40	and	and	CC
cord-015021-pol2qm74	714	41	liver	liver	NN
cord-015021-pol2qm74	714	42	play	play	VBP
cord-015021-pol2qm74	714	43	a	a	DT
cord-015021-pol2qm74	714	44	role	role	NN
cord-015021-pol2qm74	714	45	in	in	IN
cord-015021-pol2qm74	714	46	the	the	DT
cord-015021-pol2qm74	714	47	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	714	48	of	of	IN
cord-015021-pol2qm74	714	49	the	the	DT
cord-015021-pol2qm74	714	50	immunologic	immunologic	JJ
cord-015021-pol2qm74	714	51	derangements	derangement	NNS
cord-015021-pol2qm74	714	52	of	of	IN
cord-015021-pol2qm74	714	53	critical	critical	JJ
cord-015021-pol2qm74	714	54	illness	illness	NN
cord-015021-pol2qm74	714	55	.	.	.
cord-015021-pol2qm74	715	1	Prolonged	prolonged	JJ
cord-015021-pol2qm74	715	2	feeding	feeding	NN
cord-015021-pol2qm74	715	3	of	of	IN
cord-015021-pol2qm74	715	4	two	two	CD
cord-015021-pol2qm74	715	5	clinically	clinically	RB
cord-015021-pol2qm74	715	6	relevant	relevant	JJ
cord-015021-pol2qm74	715	7	killed	kill	VBD
cord-015021-pol2qm74	715	8	organisms	organism	NNS
cord-015021-pol2qm74	715	9	-	-	:
cord-015021-pol2qm74	715	10	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	715	11	and	and	CC
cord-015021-pol2qm74	715	12	Candida	Candida	NNP
cord-015021-pol2qm74	715	13	-	-	:
cord-015021-pol2qm74	715	14	to	to	IN
cord-015021-pol2qm74	715	15	a	a	DT
cord-015021-pol2qm74	715	16	rat	rat	NN
cord-015021-pol2qm74	715	17	results	result	NNS
cord-015021-pol2qm74	715	18	in	in	IN
cord-015021-pol2qm74	715	19	significant	significant	JJ
cord-015021-pol2qm74	715	20	impairment	impairment	NN
cord-015021-pol2qm74	715	21	of	of	IN
cord-015021-pol2qm74	715	22	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	715	23	delayed	delay	VBN
cord-015021-pol2qm74	715	24	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	715	25	(	(	-LRB-
cord-015021-pol2qm74	715	26	DH	DH	NNP
cord-015021-pol2qm74	715	27	)	)	-RRB-
cord-015021-pol2qm74	715	28	reactivity	reactivity	NN
cord-015021-pol2qm74	715	29	.	.	.
cord-015021-pol2qm74	716	1	Conversely	conversely	RB
cord-015021-pol2qm74	716	2	,	,	,
cord-015021-pol2qm74	716	3	measures	measure	NNS
cord-015021-pol2qm74	716	4	directed	direct	VBN
cord-015021-pol2qm74	716	5	against	against	IN
cord-015021-pol2qm74	716	6	Gram	gram	NN
cord-015021-pol2qm74	716	7	negative	negative	JJ
cord-015021-pol2qm74	716	8	bacterial	bacterial	JJ
cord-015021-pol2qm74	716	9	overgrowth	overgrowth	NN
cord-015021-pol2qm74	716	10	in	in	IN
cord-015021-pol2qm74	716	11	experimental	experimental	JJ
cord-015021-pol2qm74	716	12	peritonitis	peritonitis	NN
cord-015021-pol2qm74	716	13	result	result	VB
cord-015021-pol2qm74	716	14	in	in	IN
cord-015021-pol2qm74	716	15	partial	partial	JJ
cord-015021-pol2qm74	716	16	restoration	restoration	NN
cord-015021-pol2qm74	716	17	of	of	IN
cord-015021-pol2qm74	716	18	impaired	impaired	JJ
cord-015021-pol2qm74	716	19	DH	dh	NN
cord-015021-pol2qm74	716	20	reactivity	reactivity	NN
cord-015021-pol2qm74	716	21	.	.	.
cord-015021-pol2qm74	717	1	To	to	TO
cord-015021-pol2qm74	717	2	ascertain	ascertain	VB
cord-015021-pol2qm74	717	3	the	the	DT
cord-015021-pol2qm74	717	4	role	role	NN
cord-015021-pol2qm74	717	5	of	of	IN
cord-015021-pol2qm74	717	6	the	the	DT
cord-015021-pol2qm74	717	7	liver	liver	NN
cord-015021-pol2qm74	717	8	in	in	IN
cord-015021-pol2qm74	717	9	the	the	DT
cord-015021-pol2qm74	717	10	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	717	11	of	of	IN
cord-015021-pol2qm74	717	12	these	these	DT
cord-015021-pol2qm74	717	13	alterations	alteration	NNS
cord-015021-pol2qm74	717	14	,	,	,
cord-015021-pol2qm74	717	15	we	-PRON-	PRP
cord-015021-pol2qm74	717	16	studied	study	VBD
cord-015021-pol2qm74	717	17	the	the	DT
cord-015021-pol2qm74	717	18	differential	differential	JJ
cord-015021-pol2qm74	717	19	immunologic	immunologic	JJ
cord-015021-pol2qm74	717	20	sequelae	sequela	NNS
cord-015021-pol2qm74	717	21	of	of	IN
cord-015021-pol2qm74	717	22	portal	portal	NN
cord-015021-pol2qm74	717	23	versus	versus	IN
cord-015021-pol2qm74	717	24	systemic	systemic	JJ
cord-015021-pol2qm74	717	25	(	(	-LRB-
cord-015021-pol2qm74	717	26	IVC	IVC	NNP
cord-015021-pol2qm74	717	27	)	)	-RRB-
cord-015021-pol2qm74	717	28	infusion	infusion	NN
cord-015021-pol2qm74	717	29	of	of	IN
cord-015021-pol2qm74	717	30	killed	kill	VBN
cord-015021-pol2qm74	717	31	bacteria	bacteria	NNS
cord-015021-pol2qm74	717	32	.	.	.
cord-015021-pol2qm74	718	1	Experimental	experimental	JJ
cord-015021-pol2qm74	718	2	infusion	infusion	NN
cord-015021-pol2qm74	718	3	of	of	IN
cord-015021-pol2qm74	718	4	live	live	NN
cord-015021-pol2qm74	718	5	or	or	CC
cord-015021-pol2qm74	718	6	killed	kill	VBD
cord-015021-pol2qm74	718	7	Gram	Gram	NNP
cord-015021-pol2qm74	718	8	negative	negative	JJ
cord-015021-pol2qm74	718	9	organisms	organism	NNS
cord-015021-pol2qm74	718	10	into	into	IN
cord-015021-pol2qm74	718	11	the	the	DT
cord-015021-pol2qm74	718	12	portal	portal	JJ
cord-015021-pol2qm74	718	13	vein	vein	NN
cord-015021-pol2qm74	718	14	produces	produce	VBZ
cord-015021-pol2qm74	718	15	DH	DH	NNP
cord-015021-pol2qm74	718	16	suppression	suppression	NN
cord-015021-pol2qm74	718	17	in	in	IN
cord-015021-pol2qm74	718	18	rive	rive	NNP
cord-015021-pol2qm74	718	19	,	,	,
cord-015021-pol2qm74	718	20	and	and	CC
cord-015021-pol2qm74	718	21	profound	profound	JJ
cord-015021-pol2qm74	718	22	suppression	suppression	NN
cord-015021-pol2qm74	718	23	of	of	IN
cord-015021-pol2qm74	718	24	mitogen	mitogen	NN
cord-015021-pol2qm74	718	25	-	-	HYPH
cord-015021-pol2qm74	718	26	driven	drive	VBN
cord-015021-pol2qm74	718	27	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	718	28	proliferation	proliferation	NN
cord-015021-pol2qm74	718	29	in	in	IN
cord-015021-pol2qm74	718	30	vitro	vitro	FW
cord-015021-pol2qm74	718	31	;	;	:
cord-015021-pol2qm74	719	1	systemic	systemic	JJ
cord-015021-pol2qm74	719	2	administration	administration	NN
cord-015021-pol2qm74	719	3	of	of	IN
cord-015021-pol2qm74	719	4	the	the	DT
cord-015021-pol2qm74	719	5	same	same	JJ
cord-015021-pol2qm74	719	6	organism	organism	NN
cord-015021-pol2qm74	719	7	has	have	VBZ
cord-015021-pol2qm74	719	8	no	no	DT
cord-015021-pol2qm74	719	9	effect	effect	NN
cord-015021-pol2qm74	719	10	on	on	IN
cord-015021-pol2qm74	719	11	these	these	DT
cord-015021-pol2qm74	719	12	phenomena	phenomenon	NNS
cord-015021-pol2qm74	719	13	.	.	.
cord-015021-pol2qm74	720	1	Suppression	suppression	NN
cord-015021-pol2qm74	720	2	is	be	VBZ
cord-015021-pol2qm74	720	3	TGF3-dependent	TGF3-dependent	NNP
cord-015021-pol2qm74	720	4	,	,	,
cord-015021-pol2qm74	720	5	and	and	CC
cord-015021-pol2qm74	720	6	mediated	mediate	VBN
cord-015021-pol2qm74	720	7	by	by	IN
cord-015021-pol2qm74	720	8	a	a	DT
cord-015021-pol2qm74	720	9	soluble	soluble	JJ
cord-015021-pol2qm74	720	10	factor	factor	NN
cord-015021-pol2qm74	720	11	released	release	VBN
cord-015021-pol2qm74	720	12	by	by	IN
cord-015021-pol2qm74	720	13	fixed	fix	VBN
cord-015021-pol2qm74	720	14	tissue	tissue	NN
cord-015021-pol2qm74	720	15	macrophages	macrophage	NNS
cord-015021-pol2qm74	720	16	of	of	IN
cord-015021-pol2qm74	720	17	the	the	DT
cord-015021-pol2qm74	720	18	lung	lung	NN
cord-015021-pol2qm74	720	19	and	and	CC
cord-015021-pol2qm74	720	20	spleen	spleen	NNS
cord-015021-pol2qm74	720	21	.	.	.
cord-015021-pol2qm74	721	1	The	the	DT
cord-015021-pol2qm74	721	2	suppressive	suppressive	JJ
cord-015021-pol2qm74	721	3	influence	influence	NN
cord-015021-pol2qm74	721	4	appears	appear	VBZ
cord-015021-pol2qm74	721	5	to	to	TO
cord-015021-pol2qm74	721	6	be	be	VB
cord-015021-pol2qm74	721	7	mediated	mediate	VBN
cord-015021-pol2qm74	721	8	at	at	IN
cord-015021-pol2qm74	721	9	the	the	DT
cord-015021-pol2qm74	721	10	level	level	NN
cord-015021-pol2qm74	721	11	of	of	IN
cord-015021-pol2qm74	721	12	interactions	interaction	NNS
cord-015021-pol2qm74	721	13	between	between	IN
cord-015021-pol2qm74	721	14	IL-2	IL-2	NNP
cord-015021-pol2qm74	721	15	and	and	CC
cord-015021-pol2qm74	721	16	its	-PRON-	PRP$
cord-015021-pol2qm74	721	17	high	high	JJ
cord-015021-pol2qm74	721	18	affinity	affinity	NN
cord-015021-pol2qm74	721	19	receptor	receptor	NN
cord-015021-pol2qm74	721	20	.	.	.
cord-015021-pol2qm74	722	1	Release	release	NN
cord-015021-pol2qm74	722	2	of	of	IN
cord-015021-pol2qm74	722	3	this	this	DT
cord-015021-pol2qm74	722	4	factor	factor	NN
cord-015021-pol2qm74	722	5	can	can	MD
cord-015021-pol2qm74	722	6	be	be	VB
cord-015021-pol2qm74	722	7	induced	induce	VBN
cord-015021-pol2qm74	722	8	by	by	IN
cord-015021-pol2qm74	722	9	a	a	DT
cord-015021-pol2qm74	722	10	second	second	JJ
cord-015021-pol2qm74	722	11	circulating	circulate	VBG
cord-015021-pol2qm74	722	12	factor	factor	NN
cord-015021-pol2qm74	722	13	present	present	JJ
cord-015021-pol2qm74	722	14	in	in	IN
cord-015021-pol2qm74	722	15	the	the	DT
cord-015021-pol2qm74	722	16	plasma	plasma	NN
cord-015021-pol2qm74	722	17	of	of	IN
cord-015021-pol2qm74	722	18	portally-	portally-	NN
cord-015021-pol2qm74	722	19	,	,	,
cord-015021-pol2qm74	722	20	but	but	CC
cord-015021-pol2qm74	722	21	not	not	RB
cord-015021-pol2qm74	722	22	systemically	systemically	RB
cord-015021-pol2qm74	722	23	-	-	HYPH
cord-015021-pol2qm74	722	24	infused	infuse	VBN
cord-015021-pol2qm74	722	25	animals	animal	NNS
cord-015021-pol2qm74	722	26	two	two	CD
cord-015021-pol2qm74	722	27	hours	hour	NNS
cord-015021-pol2qm74	722	28	after	after	IN
cord-015021-pol2qm74	722	29	bacterial	bacterial	JJ
cord-015021-pol2qm74	722	30	administration	administration	NN
cord-015021-pol2qm74	722	31	.	.	.
cord-015021-pol2qm74	723	1	These	these	DT
cord-015021-pol2qm74	723	2	studies	study	NNS
cord-015021-pol2qm74	723	3	suggest	suggest	VBP
cord-015021-pol2qm74	723	4	that	that	IN
cord-015021-pol2qm74	723	5	the	the	DT
cord-015021-pol2qm74	723	6	release	release	NN
cord-015021-pol2qm74	723	7	of	of	IN
cord-015021-pol2qm74	723	8	inducible	inducible	JJ
cord-015021-pol2qm74	723	9	immunoregulatory	immunoregulatory	JJ
cord-015021-pol2qm74	723	10	factors	factor	NNS
cord-015021-pol2qm74	723	11	from	from	IN
cord-015021-pol2qm74	723	12	the	the	DT
cord-015021-pol2qm74	723	13	liver	liver	NN
cord-015021-pol2qm74	723	14	,	,	,
cord-015021-pol2qm74	723	15	and	and	CC
cord-015021-pol2qm74	723	16	possibly	possibly	RB
cord-015021-pol2qm74	723	17	from	from	IN
cord-015021-pol2qm74	723	18	the	the	DT
cord-015021-pol2qm74	723	19	gut	gut	NN
cord-015021-pol2qm74	723	20	,	,	,
cord-015021-pol2qm74	723	21	may	may	MD
cord-015021-pol2qm74	723	22	play	play	VB
cord-015021-pol2qm74	723	23	a	a	DT
cord-015021-pol2qm74	723	24	role	role	NN
cord-015021-pol2qm74	723	25	in	in	IN
cord-015021-pol2qm74	723	26	the	the	DT
cord-015021-pol2qm74	723	27	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	723	28	of	of	IN
cord-015021-pol2qm74	723	29	the	the	DT
cord-015021-pol2qm74	723	30	profound	profound	JJ
cord-015021-pol2qm74	723	31	derangements	derangement	NNS
cord-015021-pol2qm74	723	32	of	of	IN
cord-015021-pol2qm74	723	33	systemic	systemic	JJ
cord-015021-pol2qm74	723	34	immune	immune	JJ
cord-015021-pol2qm74	723	35	homeostasis	homeostasis	NN
cord-015021-pol2qm74	723	36	that	that	WDT
cord-015021-pol2qm74	723	37	accompany	accompany	VBP
cord-015021-pol2qm74	723	38	trauma	trauma	NN
cord-015021-pol2qm74	723	39	and	and	CC
cord-015021-pol2qm74	723	40	critical	critical	JJ
cord-015021-pol2qm74	723	41	illness	illness	NN
cord-015021-pol2qm74	723	42	.	.	.
cord-015021-pol2qm74	724	1	Acad	Acad	NNP
cord-015021-pol2qm74	724	2	.	.	.
cord-015021-pol2qm74	725	1	Hospital	Hospital	NNP
cord-015021-pol2qm74	725	2	St.	St.	NNP
cord-015021-pol2qm74	725	3	Radboud	Radboud	NNP
cord-015021-pol2qm74	725	4	,	,	,
cord-015021-pol2qm74	725	5	Postbus	Postbus	NNP
cord-015021-pol2qm74	725	6	9101,6500	9101,6500	CD
cord-015021-pol2qm74	725	7	lib	lib	NN
cord-015021-pol2qm74	726	1	Nijmegen	Nijmegen	NNP
cord-015021-pol2qm74	726	2	Introduction	Introduction	NNP
cord-015021-pol2qm74	726	3	.	.	.
cord-015021-pol2qm74	727	1	The	the	DT
cord-015021-pol2qm74	727	2	central	central	JJ
cord-015021-pol2qm74	727	3	question	question	NN
cord-015021-pol2qm74	727	4	being	be	VBG
cord-015021-pol2qm74	727	5	tested	test	VBN
cord-015021-pol2qm74	727	6	in	in	IN
cord-015021-pol2qm74	727	7	this	this	DT
cord-015021-pol2qm74	727	8	study	study	NN
cord-015021-pol2qm74	727	9	was	be	VBD
cord-015021-pol2qm74	727	10	whether	whether	IN
cord-015021-pol2qm74	727	11	liposome	liposome	NN
cord-015021-pol2qm74	727	12	encapsulated	encapsulate	VBN
cord-015021-pol2qm74	727	13	dichloromethyLene	dichloromethylene	JJ
cord-015021-pol2qm74	727	14	-	-	HYPH
cord-015021-pol2qm74	727	15	diphosphonate	diphosphonate	JJ
cord-015021-pol2qm74	727	16	(	(	-LRB-
cord-015021-pol2qm74	727	17	CI2MDP	ci2mdp	NN
cord-015021-pol2qm74	727	18	)	)	-RRB-
cord-015021-pol2qm74	727	19	mediated	mediate	VBN
cord-015021-pol2qm74	727	20	elimination	elimination	NN
cord-015021-pol2qm74	727	21	of	of	IN
cord-015021-pol2qm74	727	22	liver	liver	NN
cord-015021-pol2qm74	727	23	and	and	CC
cord-015021-pol2qm74	727	24	splenic	splenic	JJ
cord-015021-pol2qm74	727	25	maorophages	maorophage	NNS
cord-015021-pol2qm74	727	26	would	would	MD
cord-015021-pol2qm74	727	27	influence	influence	VB
cord-015021-pol2qm74	728	1	zymosan	zymosan	NNP
cord-015021-pol2qm74	728	2	induced	induce	VBD
cord-015021-pol2qm74	728	3	systemic	systemic	JJ
cord-015021-pol2qm74	728	4	toxicity	toxicity	NN
cord-015021-pol2qm74	728	5	(	(	-LRB-
cord-015021-pol2qm74	728	6	ST	ST	NNP
cord-015021-pol2qm74	728	7	)	)	-RRB-
cord-015021-pol2qm74	728	8	and	and	CC
cord-015021-pol2qm74	728	9	bacterial	bacterial	JJ
cord-015021-pol2qm74	728	10	lranslocation	lranslocation	NN
cord-015021-pol2qm74	728	11	(	(	-LRB-
cord-015021-pol2qm74	728	12	BT	BT	NNP
cord-015021-pol2qm74	728	13	)	)	-RRB-
cord-015021-pol2qm74	728	14	.	.	.
cord-015021-pol2qm74	729	1	Materia|s	Materia|s	NNP
cord-015021-pol2qm74	729	2	and	and	CC
cord-015021-pol2qm74	729	3	Methods	Methods	NNPS
cord-015021-pol2qm74	729	4	.	.	.
cord-015021-pol2qm74	730	1	90	90	CD
cord-015021-pol2qm74	730	2	male	male	JJ
cord-015021-pol2qm74	730	3	Swiss	Swiss	NNP
cord-015021-pol2qm74	730	4	(	(	-LRB-
cord-015021-pol2qm74	730	5	ICR	ICR	NNP
cord-015021-pol2qm74	730	6	)	)	-RRB-
cord-015021-pol2qm74	730	7	mice	mouse	NNS
cord-015021-pol2qm74	730	8	were	be	VBD
cord-015021-pol2qm74	730	9	used	use	VBN
cord-015021-pol2qm74	730	10	weighing	weigh	VBG
cord-015021-pol2qm74	730	11	21	21	CD
cord-015021-pol2qm74	730	12	-	-	SYM
cord-015021-pol2qm74	730	13	25	25	CD
cord-015021-pol2qm74	730	14	g	g	NNP
cord-015021-pol2qm74	730	15	Elimination	Elimination	NNP
cord-015021-pol2qm74	730	16	of	of	IN
cord-015021-pol2qm74	730	17	liver	liver	NN
cord-015021-pol2qm74	730	18	and	and	CC
cord-015021-pol2qm74	730	19	spleen	spleen	NN
cord-015021-pol2qm74	730	20	macrophages	macrophage	NNS
cord-015021-pol2qm74	730	21	was	be	VBD
cord-015021-pol2qm74	730	22	accomplished	accomplish	VBN
cord-015021-pol2qm74	730	23	by	by	IN
cord-015021-pol2qm74	730	24	intravenous	intravenous	JJ
cord-015021-pol2qm74	730	25	injection	injection	NN
cord-015021-pol2qm74	730	26	of	of	IN
cord-015021-pol2qm74	730	27	200/11	200/11	CD
cord-015021-pol2qm74	730	28	suspension	suspension	NN
cord-015021-pol2qm74	730	29	of	of	IN
cord-015021-pol2qm74	730	30	CI2MDP	ci2mdp	NN
cord-015021-pol2qm74	730	31	-	-	HYPH
cord-015021-pol2qm74	730	32	liposome	liposome	NN
cord-015021-pol2qm74	730	33	suspension	suspension	NN
cord-015021-pol2qm74	730	34	.	.	.
cord-015021-pol2qm74	731	1	Control	control	NN
cord-015021-pol2qm74	731	2	mice	mouse	NNS
cord-015021-pol2qm74	731	3	received	receive	VBD
cord-015021-pol2qm74	731	4	an	an	DT
cord-015021-pol2qm74	731	5	i.v	i.v	NNP
cord-015021-pol2qm74	731	6	.	.	.
cord-015021-pol2qm74	731	7	injection	injection	NN
cord-015021-pol2qm74	731	8	with	with	IN
cord-015021-pol2qm74	731	9	200	200	CD
cord-015021-pol2qm74	731	10	pt	pt	NN
cord-015021-pol2qm74	731	11	phosphate	phosphate	NN
cord-015021-pol2qm74	731	12	-	-	HYPH
cord-015021-pol2qm74	731	13	buffered	buffer	VBN
cord-015021-pol2qm74	731	14	saline	saline	NN
cord-015021-pol2qm74	731	15	(	(	-LRB-
cord-015021-pol2qm74	731	16	PBS	PBS	NNP
cord-015021-pol2qm74	731	17	)	)	-RRB-
cord-015021-pol2qm74	731	18	.	.	.
cord-015021-pol2qm74	732	1	Two	two	CD
cord-015021-pol2qm74	732	2	days	day	NNS
cord-015021-pol2qm74	732	3	later	later	RBR
cord-015021-pol2qm74	732	4	all	all	DT
cord-015021-pol2qm74	732	5	mice	mouse	NNS
cord-015021-pol2qm74	732	6	were	be	VBD
cord-015021-pol2qm74	732	7	challenged	challenge	VBN
cord-015021-pol2qm74	732	8	with	with	IN
cord-015021-pol2qm74	732	9	an	an	DT
cord-015021-pol2qm74	732	10	i.p	i.p	NNP
cord-015021-pol2qm74	732	11	.	.	NNP
cord-015021-pol2qm74	732	12	injection	injection	NN
cord-015021-pol2qm74	732	13	of	of	IN
cord-015021-pol2qm74	732	14	zymosan	zymosan	NNP
cord-015021-pol2qm74	732	15	suspended	suspend	VBN
cord-015021-pol2qm74	732	16	in	in	IN
cord-015021-pol2qm74	732	17	paraffin	paraffin	NN
cord-015021-pol2qm74	732	18	(	(	-LRB-
cord-015021-pol2qm74	732	19	Z	z	NN
cord-015021-pol2qm74	732	20	)	)	-RRB-
cord-015021-pol2qm74	732	21	at	at	IN
cord-015021-pol2qm74	732	22	a	a	DT
cord-015021-pol2qm74	732	23	dosage	dosage	NN
cord-015021-pol2qm74	732	24	Of	of	IN
cord-015021-pol2qm74	732	25	either	either	DT
cord-015021-pol2qm74	732	26	01	01	CD
cord-015021-pol2qm74	732	27	mg	mg	NNP
cord-015021-pol2qm74	732	28	/	/	SYM
cord-015021-pol2qm74	732	29	g	g	NNP
cord-015021-pol2qm74	732	30	,	,	,
cord-015021-pol2qm74	732	31	0.5	0.5	CD
cord-015021-pol2qm74	732	32	mg	mg	NNP
cord-015021-pol2qm74	732	33	/	/	SYM
cord-015021-pol2qm74	732	34	g	g	NN
cord-015021-pol2qm74	732	35	or	or	CC
cord-015021-pol2qm74	732	36	1.0	1.0	CD
cord-015021-pol2qm74	732	37	mg	mg	NN
cord-015021-pol2qm74	732	38	/	/	SYM
cord-015021-pol2qm74	732	39	g	g	NN
cord-015021-pol2qm74	732	40	body	body	NN
cord-015021-pol2qm74	732	41	weight	weight	NN
cord-015021-pol2qm74	732	42	(	(	-LRB-
cord-015021-pol2qm74	732	43	n=8	n=8	NN
cord-015021-pol2qm74	732	44	in	in	IN
cord-015021-pol2qm74	732	45	each	each	DT
cord-015021-pol2qm74	732	46	group	group	NN
cord-015021-pol2qm74	732	47	)	)	-RRB-
cord-015021-pol2qm74	732	48	,	,	,
cord-015021-pol2qm74	732	49	Signs	Signs	NNPS
cord-015021-pol2qm74	732	50	of	of	IN
cord-015021-pol2qm74	732	51	ST	ST	NNP
cord-015021-pol2qm74	732	52	and	and	CC
cord-015021-pol2qm74	732	53	bacterial	bacterial	JJ
cord-015021-pol2qm74	732	54	translocation	translocation	NN
cord-015021-pol2qm74	732	55	BT	BT	NNP
cord-015021-pol2qm74	732	56	were	be	VBD
cord-015021-pol2qm74	732	57	measured	measure	VBN
cord-015021-pol2qm74	732	58	24	24	CD
cord-015021-pol2qm74	732	59	hours	hour	NNS
cord-015021-pol2qm74	732	60	later	later	RB
cord-015021-pol2qm74	732	61	The	the	DT
cord-015021-pol2qm74	732	62	ST	ST	NNP
cord-015021-pol2qm74	732	63	was	be	VBD
cord-015021-pol2qm74	732	64	assessed	assess	VBN
cord-015021-pol2qm74	732	65	by	by	IN
cord-015021-pol2qm74	732	66	blindly	blindly	RB
cord-015021-pol2qm74	732	67	grading	grade	VBG
cord-015021-pol2qm74	732	68	the	the	DT
cord-015021-pol2qm74	732	69	degree	degree	NN
cord-015021-pol2qm74	732	70	of	of	IN
cord-015021-pol2qm74	732	71	lethargy	lethargy	NN
cord-015021-pol2qm74	732	72	,	,	,
cord-015021-pol2qm74	732	73	conjunctivitis	conjunctivitis	NN
cord-015021-pol2qm74	732	74	,	,	,
cord-015021-pol2qm74	732	75	diarrhea	diarrhea	NN
cord-015021-pol2qm74	732	76	,	,	,
cord-015021-pol2qm74	732	77	and	and	CC
cord-015021-pol2qm74	732	78	ruffled	ruffled	JJ
cord-015021-pol2qm74	732	79	fur	fur	NN
cord-015021-pol2qm74	732	80	of	of	IN
cord-015021-pol2qm74	732	81	each	each	DT
cord-015021-pol2qm74	732	82	mouse	mouse	NN
cord-015021-pol2qm74	732	83	on	on	IN
cord-015021-pol2qm74	732	84	a	a	DT
cord-015021-pol2qm74	732	85	four	four	CD
cord-015021-pol2qm74	732	86	point	point	NN
cord-015021-pol2qm74	732	87	scale	scale	NN
cord-015021-pol2qm74	732	88	.	.	.
cord-015021-pol2qm74	733	1	BT	BT	NNP
cord-015021-pol2qm74	733	2	to	to	IN
cord-015021-pol2qm74	733	3	the	the	DT
cord-015021-pol2qm74	733	4	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	733	5	lymph	lymph	NN
cord-015021-pol2qm74	733	6	nodes	node	NNS
cord-015021-pol2qm74	733	7	(	(	-LRB-
cord-015021-pol2qm74	733	8	MLN	mln	NN
cord-015021-pol2qm74	733	9	)	)	-RRB-
cord-015021-pol2qm74	733	10	and	and	CC
cord-015021-pol2qm74	733	11	systemic	systemic	JJ
cord-015021-pol2qm74	733	12	organs	organ	NNS
cord-015021-pol2qm74	733	13	(	(	-LRB-
cord-015021-pol2qm74	733	14	liver	liver	NN
cord-015021-pol2qm74	733	15	,	,	,
cord-015021-pol2qm74	733	16	spleen	spleen	NNS
cord-015021-pol2qm74	733	17	,	,	,
cord-015021-pol2qm74	733	18	lung	lung	NN
cord-015021-pol2qm74	733	19	and	and	CC
cord-015021-pol2qm74	733	20	blood	blood	NN
cord-015021-pol2qm74	733	21	)	)	-RRB-
cord-015021-pol2qm74	733	22	was	be	VBD
cord-015021-pol2qm74	733	23	tested	test	VBN
cord-015021-pol2qm74	733	24	by	by	IN
cord-015021-pol2qm74	733	25	culturing	culture	VBG
cord-015021-pol2qm74	733	26	on	on	IN
cord-015021-pol2qm74	733	27	blood	blood	NN
cord-015021-pol2qm74	733	28	and	and	CC
cord-015021-pol2qm74	733	29	MacConkey	MacConkey	NNP
cord-015021-pol2qm74	733	30	's	's	POS
cord-015021-pol2qm74	733	31	agar	agar	NN
cord-015021-pol2qm74	733	32	At	at	IN
cord-015021-pol2qm74	733	33	the	the	DT
cord-015021-pol2qm74	733	34	time	time	NN
cord-015021-pol2qm74	733	35	of	of	IN
cord-015021-pol2qm74	733	36	sacrifice	sacrifice	NN
cord-015021-pol2qm74	733	37	sections	section	NNS
cord-015021-pol2qm74	733	38	of	of	IN
cord-015021-pol2qm74	733	39	the	the	DT
cord-015021-pol2qm74	733	40	distal	distal	JJ
cord-015021-pol2qm74	733	41	ileum	ileum	NN
cord-015021-pol2qm74	733	42	were	be	VBD
cord-015021-pol2qm74	733	43	taken	take	VBN
cord-015021-pol2qm74	733	44	for	for	IN
cord-015021-pol2qm74	733	45	histology	histology	NN
cord-015021-pol2qm74	733	46	.	.	.
cord-015021-pol2qm74	734	1	An	an	DT
cord-015021-pol2qm74	734	2	additional	additional	JJ
cord-015021-pol2qm74	734	3	two	two	CD
cord-015021-pol2qm74	734	4	control	control	NN
cord-015021-pol2qm74	734	5	groups	group	NNS
cord-015021-pol2qm74	734	6	(	(	-LRB-
cord-015021-pol2qm74	734	7	n=6	n=6	JJ
cord-015021-pol2qm74	734	8	in	in	IN
cord-015021-pol2qm74	734	9	each	each	DT
cord-015021-pol2qm74	734	10	group	group	NN
cord-015021-pol2qm74	734	11	)	)	-RRB-
cord-015021-pol2qm74	734	12	were	be	VBD
cord-015021-pol2qm74	734	13	tested	test	VBN
cord-015021-pol2qm74	734	14	to	to	TO
cord-015021-pol2qm74	734	15	verify	verify	VB
cord-015021-pol2qm74	734	16	that	that	IN
cord-015021-pol2qm74	734	17	neither	neither	CC
cord-015021-pol2qm74	734	18	paraffin	paraffin	NN
cord-015021-pol2qm74	734	19	nor	nor	CC
cord-015021-pol2qm74	734	20	PBS	PBS	NNP
cord-015021-pol2qm74	734	21	or	or	CC
cord-015021-pol2qm74	734	22	CI2MDPqiposome	CI2MDPqiposome	NNP
cord-015021-pol2qm74	734	23	suspension	suspension	NN
cord-015021-pol2qm74	734	24	alone	alone	RB
cord-015021-pol2qm74	734	25	induced	induce	VBN
cord-015021-pol2qm74	734	26	BT	BT	NNP
cord-015021-pol2qm74	734	27	or	or	CC
cord-015021-pol2qm74	734	28	ST	ST	NNP
cord-015021-pol2qm74	734	29	.	.	.
cord-015021-pol2qm74	735	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	735	2	survival	survival	NN
cord-015021-pol2qm74	735	3	over	over	IN
cord-015021-pol2qm74	735	4	a	a	DT
cord-015021-pol2qm74	735	5	12-day	12-day	CD
cord-015021-pol2qm74	735	6	period	period	NN
cord-015021-pol2qm74	735	7	was	be	VBD
cord-015021-pol2qm74	735	8	assessed	assess	VBN
cord-015021-pol2qm74	735	9	in	in	IN
cord-015021-pol2qm74	735	10	a	a	DT
cord-015021-pol2qm74	735	11	control	control	NN
cord-015021-pol2qm74	735	12	and	and	CC
cord-015021-pol2qm74	735	13	macrophage	macrophage	NN
cord-015021-pol2qm74	735	14	-	-	HYPH
cord-015021-pol2qm74	735	15	depleted	deplete	VBN
cord-015021-pol2qm74	735	16	group	group	NN
cord-015021-pol2qm74	735	17	with	with	IN
cord-015021-pol2qm74	735	18	a	a	DT
cord-015021-pol2qm74	735	19	dose	dose	NN
cord-015021-pol2qm74	735	20	of	of	IN
cord-015021-pol2qm74	735	21	1D	1d	CD
cord-015021-pol2qm74	735	22	mg	mg	NNP
cord-015021-pol2qm74	735	23	/	/	SYM
cord-015021-pol2qm74	735	24	g	g	NNP
cord-015021-pol2qm74	735	25	Z.	Z.	NNP
cord-015021-pol2qm74	735	26	Results	Results	NNP
cord-015021-pol2qm74	735	27	.	.	.
cord-015021-pol2qm74	736	1	Neither	neither	CC
cord-015021-pol2qm74	736	2	the	the	DT
cord-015021-pol2qm74	736	3	paraffin	paraffin	NN
cord-015021-pol2qm74	736	4	nor	nor	CC
cord-015021-pol2qm74	736	5	CI2MDP	ci2mdp	NN
cord-015021-pol2qm74	736	6	-	-	HYPH
cord-015021-pol2qm74	736	7	tiposome	tiposome	NN
cord-015021-pol2qm74	736	8	suspension	suspension	NN
cord-015021-pol2qm74	736	9	induced	induce	VBN
cord-015021-pol2qm74	736	10	BT	BT	NNP
cord-015021-pol2qm74	736	11	or	or	CC
cord-015021-pol2qm74	736	12	ST	ST	NNP
cord-015021-pol2qm74	737	1	The	the	DT
cord-015021-pol2qm74	737	2	incidence	incidence	NN
cord-015021-pol2qm74	737	3	of	of	IN
cord-015021-pol2qm74	737	4	bacterial	bacterial	JJ
cord-015021-pol2qm74	737	5	translocation	translocation	NN
cord-015021-pol2qm74	737	6	to	to	IN
cord-015021-pol2qm74	737	7	the	the	DT
cord-015021-pol2qm74	737	8	MLN	mln	NN
cord-015021-pol2qm74	737	9	was	be	VBD
cord-015021-pol2qm74	737	10	similar	similar	JJ
cord-015021-pol2qm74	737	11	between	between	IN
cord-015021-pol2qm74	737	12	macrophage	macrophage	NN
cord-015021-pol2qm74	737	13	depleted	deplete	VBN
cord-015021-pol2qm74	737	14	and	and	CC
cord-015021-pol2qm74	737	15	control	control	NN
cord-015021-pol2qm74	737	16	groups	group	NNS
cord-015021-pol2qm74	737	17	.	.	.
cord-015021-pol2qm74	738	1	However	however	RB
cord-015021-pol2qm74	738	2	,	,	,
cord-015021-pol2qm74	738	3	macrophage	macrophage	NN
cord-015021-pol2qm74	738	4	depletion	depletion	NN
cord-015021-pol2qm74	738	5	was	be	VBD
cord-015021-pol2qm74	738	6	associated	associate	VBN
cord-015021-pol2qm74	738	7	with	with	IN
cord-015021-pol2qm74	738	8	a	a	DT
cord-015021-pol2qm74	738	9	significantly	significantly	RB
cord-015021-pol2qm74	738	10	higher	high	JJR
cord-015021-pol2qm74	738	11	incidence	incidence	NN
cord-015021-pol2qm74	738	12	of	of	IN
cord-015021-pol2qm74	738	13	systemic	systemic	JJ
cord-015021-pol2qm74	738	14	spread	spread	NN
cord-015021-pol2qm74	738	15	of	of	IN
cord-015021-pol2qm74	738	16	bacteria	bacteria	NNS
cord-015021-pol2qm74	738	17	.	.	.
cord-015021-pol2qm74	739	1	Data	datum	NNS
cord-015021-pol2qm74	739	2	expressed	express	VBN
cord-015021-pol2qm74	739	3	as	as	IN
cord-015021-pol2qm74	739	4	positive	positive	JJ
cord-015021-pol2qm74	739	5	tissues	tissue	NNS
cord-015021-pol2qm74	739	6	/	/	SYM
cord-015021-pol2qm74	739	7	total	total	JJ
cord-015021-pol2qm74	739	8	tissues	tissue	NNS
cord-015021-pol2qm74	739	9	tested	test	VBN
cord-015021-pol2qm74	739	10	:	:	:
cord-015021-pol2qm74	739	11	11/32	11/32	CD
cord-015021-pol2qm74	739	12	vs.	vs.	CC
cord-015021-pol2qm74	739	13	1/32	1/32	CD
cord-015021-pol2qm74	739	14	at	at	IN
cord-015021-pol2qm74	739	15	0.1	0.1	CD
cord-015021-pol2qm74	739	16	mg	mg	NN
cord-015021-pol2qm74	739	17	/	/	SYM
cord-015021-pol2qm74	739	18	g	g	NNP
cord-015021-pol2qm74	739	19	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	739	20	(	(	-LRB-
cord-015021-pol2qm74	739	21	p	p	NN
cord-015021-pol2qm74	739	22	~	~	CD
cord-015021-pol2qm74	739	23	O.01	o.01	CD
cord-015021-pol2qm74	739	24	)	)	-RRB-
cord-015021-pol2qm74	739	25	;	;	:
cord-015021-pol2qm74	739	26	19132	19132	CD
cord-015021-pol2qm74	739	27	vs.	vs.	CC
cord-015021-pol2qm74	739	28	10132	10132	CD
cord-015021-pol2qm74	739	29	at	at	IN
cord-015021-pol2qm74	739	30	05	05	CD
cord-015021-pol2qm74	739	31	mg	mg	NNP
cord-015021-pol2qm74	739	32	/	/	SYM
cord-015021-pol2qm74	739	33	g	g	NNP
cord-015021-pol2qm74	739	34	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	739	35	(	(	-LRB-
cord-015021-pol2qm74	739	36	p	p	NN
cord-015021-pol2qm74	739	37	~	~	NFP
cord-015021-pol2qm74	739	38	Q05	Q05	NNP
cord-015021-pol2qm74	739	39	)	)	-RRB-
cord-015021-pol2qm74	739	40	;	;	.
cord-015021-pol2qm74	740	1	23/32	23/32	CD
cord-015021-pol2qm74	740	2	vs.	vs.	IN
cord-015021-pol2qm74	740	3	11/32	11/32	CD
cord-015021-pol2qm74	740	4	st	st	NNP
cord-015021-pol2qm74	740	5	1.0	1.0	CD
cord-015021-pol2qm74	740	6	mg	mg	NNP
cord-015021-pol2qm74	740	7	/	/	SYM
cord-015021-pol2qm74	740	8	g	g	NNP
cord-015021-pol2qm74	740	9	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	740	10	(	(	-LRB-
cord-015021-pol2qm74	740	11	p~	p~	XX
cord-015021-pol2qm74	741	1	O.O1).The	o.o1).the	JJ
cord-015021-pol2qm74	741	2	magnitude	magnitude	NN
cord-015021-pol2qm74	741	3	of	of	IN
cord-015021-pol2qm74	741	4	BT	BT	NNP
cord-015021-pol2qm74	741	5	however	however	RB
cord-015021-pol2qm74	741	6	did	do	VBD
cord-015021-pol2qm74	741	7	not	not	RB
cord-015021-pol2qm74	741	8	show	show	VB
cord-015021-pol2qm74	741	9	any	any	DT
cord-015021-pol2qm74	741	10	differences	difference	NNS
cord-015021-pol2qm74	741	11	.	.	.
cord-015021-pol2qm74	742	1	Although	although	IN
cord-015021-pol2qm74	742	2	systemic	systemic	JJ
cord-015021-pol2qm74	742	3	BT	BT	NNP
cord-015021-pol2qm74	742	4	was	be	VBD
cord-015021-pol2qm74	742	5	greater	great	JJR
cord-015021-pol2qm74	742	6	in	in	IN
cord-015021-pol2qm74	742	7	the	the	DT
cord-015021-pol2qm74	742	8	macrophage	macrophage	NN
cord-015021-pol2qm74	742	9	depleted	deplete	VBN
cord-015021-pol2qm74	742	10	groups	group	NNS
cord-015021-pol2qm74	742	11	,	,	,
cord-015021-pol2qm74	742	12	the	the	DT
cord-015021-pol2qm74	742	13	systemic	systemic	JJ
cord-015021-pol2qm74	742	14	toxic	toxic	JJ
cord-015021-pol2qm74	742	15	response	response	NN
cord-015021-pol2qm74	742	16	was	be	VBD
cord-015021-pol2qm74	742	17	significantly	significantly	RB
cord-015021-pol2qm74	742	18	less	less	JJR
cord-015021-pol2qm74	742	19	at	at	IN
cord-015021-pol2qm74	742	20	doses	dose	NNS
cord-015021-pol2qm74	742	21	of	of	IN
cord-015021-pol2qm74	742	22	0.5	0.5	CD
cord-015021-pol2qm74	742	23	mg	mg	NNP
cord-015021-pol2qm74	742	24	/	/	SYM
cord-015021-pol2qm74	742	25	g	g	NNP
cord-015021-pol2qm74	742	26	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	742	27	(	(	-LRB-
cord-015021-pol2qm74	742	28	3.14	3.14	CD
cord-015021-pol2qm74	742	29	-+	-+	NNP
cord-015021-pol2qm74	742	30	0.69	0.69	CD
cord-015021-pol2qm74	742	31	vs.	vs.	NN
cord-015021-pol2qm74	742	32	7.13	7.13	CD
cord-015021-pol2qm74	742	33	-+	-+	NNP
cord-015021-pol2qm74	742	34	3	3	CD
cord-015021-pol2qm74	742	35	,	,	,
cord-015021-pol2qm74	742	36	p	p	NN
cord-015021-pol2qm74	742	37	~	~	CD
cord-015021-pol2qm74	742	38	O.01	o.01	CD
cord-015021-pol2qm74	742	39	)	)	-RRB-
cord-015021-pol2qm74	742	40	and	and	CC
cord-015021-pol2qm74	742	41	1.0	1.0	CD
cord-015021-pol2qm74	742	42	mg	mg	NNP
cord-015021-pol2qm74	742	43	/	/	SYM
cord-015021-pol2qm74	742	44	g	g	NNP
cord-015021-pol2qm74	742	45	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	742	46	(	(	-LRB-
cord-015021-pol2qm74	742	47	4.38	4.38	CD
cord-015021-pol2qm74	742	48	-+2.50	-+2.50	NNP
cord-015021-pol2qm74	742	49	vs.	vs.	NN
cord-015021-pol2qm74	742	50	11.25	11.25	CD
cord-015021-pol2qm74	742	51	-+	-+	.
cord-015021-pol2qm74	742	52	2.5	2.5	CD
cord-015021-pol2qm74	742	53	,	,	,
cord-015021-pol2qm74	742	54	p<_.O.01	p<_.O.01	NNP
cord-015021-pol2qm74	742	55	)	)	-RRB-
cord-015021-pol2qm74	742	56	.	.	.
cord-015021-pol2qm74	743	1	The	the	DT
cord-015021-pol2qm74	743	2	12	12	CD
cord-015021-pol2qm74	743	3	day	day	NN
cord-015021-pol2qm74	743	4	mortality	mortality	NN
cord-015021-pol2qm74	743	5	after	after	IN
cord-015021-pol2qm74	743	6	1.0	1.0	CD
cord-015021-pol2qm74	743	7	mg	mg	NNP
cord-015021-pol2qm74	743	8	/	/	SYM
cord-015021-pol2qm74	743	9	g	g	NNP
cord-015021-pol2qm74	743	10	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	743	11	was	be	VBD
cord-015021-pol2qm74	743	12	27	27	CD
cord-015021-pol2qm74	743	13	%	%	NN
cord-015021-pol2qm74	743	14	in	in	IN
cord-015021-pol2qm74	743	15	the	the	DT
cord-015021-pol2qm74	743	16	control	control	NN
cord-015021-pol2qm74	743	17	group	group	NN
cord-015021-pol2qm74	743	18	and	and	CC
cord-015021-pol2qm74	743	19	0	0	CD
cord-015021-pol2qm74	743	20	%	%	NN
cord-015021-pol2qm74	743	21	in	in	IN
cord-015021-pol2qm74	743	22	the	the	DT
cord-015021-pol2qm74	743	23	macrophage	macrophage	NN
cord-015021-pol2qm74	743	24	depleted	deplete	VBN
cord-015021-pol2qm74	743	25	group	group	NN
cord-015021-pol2qm74	743	26	(	(	-LRB-
cord-015021-pol2qm74	743	27	p	p	NN
cord-015021-pol2qm74	743	28	=	=	SYM
cord-015021-pol2qm74	743	29	O.05	o.05	NN
cord-015021-pol2qm74	743	30	)	)	-RRB-
cord-015021-pol2qm74	743	31	.	.	.
cord-015021-pol2qm74	744	1	Histology	histology	NN
cord-015021-pol2qm74	744	2	did	do	VBD
cord-015021-pol2qm74	744	3	not	not	RB
cord-015021-pol2qm74	744	4	show	show	VB
cord-015021-pol2qm74	744	5	any	any	DT
cord-015021-pol2qm74	744	6	differences	difference	NNS
cord-015021-pol2qm74	744	7	between	between	IN
cord-015021-pol2qm74	744	8	the	the	DT
cord-015021-pol2qm74	744	9	control	control	NN
cord-015021-pol2qm74	744	10	and	and	CC
cord-015021-pol2qm74	744	11	macrophage	macrophage	NN
cord-015021-pol2qm74	744	12	depleted	deplete	VBN
cord-015021-pol2qm74	744	13	groups	group	NNS
cord-015021-pol2qm74	744	14	.	.	.
cord-015021-pol2qm74	745	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	745	2	.	.	.
cord-015021-pol2qm74	746	1	The	the	DT
cord-015021-pol2qm74	746	2	lethal	lethal	JJ
cord-015021-pol2qm74	746	3	and	and	CC
cord-015021-pol2qm74	746	4	toxic	toxic	JJ
cord-015021-pol2qm74	746	5	effects	effect	NNS
cord-015021-pol2qm74	746	6	of	of	IN
cord-015021-pol2qm74	746	7	zymosan	zymosan	NNP
cord-015021-pol2qm74	746	8	in	in	IN
cord-015021-pol2qm74	746	9	this	this	DT
cord-015021-pol2qm74	746	10	model	model	NN
cord-015021-pol2qm74	746	11	appear	appear	VBP
cord-015021-pol2qm74	746	12	to	to	TO
cord-015021-pol2qm74	746	13	be	be	VB
cord-015021-pol2qm74	746	14	more	more	RBR
cord-015021-pol2qm74	746	15	related	related	JJ
cord-015021-pol2qm74	746	16	to	to	IN
cord-015021-pol2qm74	746	17	the	the	DT
cord-015021-pol2qm74	746	18	excessive	excessive	JJ
cord-015021-pol2qm74	746	19	activation	activation	NN
cord-015021-pol2qm74	746	20	of	of	IN
cord-015021-pol2qm74	746	21	macrophages	macrophage	NNS
cord-015021-pol2qm74	746	22	than	than	IN
cord-015021-pol2qm74	746	23	to	to	IN
cord-015021-pol2qm74	746	24	the	the	DT
cord-015021-pol2qm74	746	25	systemic	systemic	JJ
cord-015021-pol2qm74	746	26	spread	spread	NN
cord-015021-pol2qm74	746	27	of	of	IN
cord-015021-pol2qm74	746	28	bacteria	bacteria	NNS
cord-015021-pol2qm74	746	29	.	.	.
cord-015021-pol2qm74	747	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	747	2	translocation	translocation	NN
cord-015021-pol2qm74	747	3	(	(	-LRB-
cord-015021-pol2qm74	747	4	BT	BT	NNP
cord-015021-pol2qm74	747	5	)	)	-RRB-
cord-015021-pol2qm74	747	6	in	in	IN
cord-015021-pol2qm74	747	7	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	747	8	shock	shock	NN
cord-015021-pol2qm74	747	9	was	be	VBD
cord-015021-pol2qm74	747	10	studied	study	VBN
cord-015021-pol2qm74	747	11	using	use	VBG
cord-015021-pol2qm74	747	12	a	a	DT
cord-015021-pol2qm74	747	13	porcine	porcine	JJ
cord-015021-pol2qm74	747	14	model	model	NN
cord-015021-pol2qm74	747	15	.	.	.
cord-015021-pol2qm74	748	1	In	in	IN
cord-015021-pol2qm74	748	2	this	this	DT
cord-015021-pol2qm74	748	3	study	study	NN
cord-015021-pol2qm74	748	4	three	three	CD
cord-015021-pol2qm74	748	5	groups	group	NNS
cord-015021-pol2qm74	748	6	were	be	VBD
cord-015021-pol2qm74	748	7	randomized	randomize	VBN
cord-015021-pol2qm74	748	8	:	:	:
cord-015021-pol2qm74	748	9	one	one	CD
cord-015021-pol2qm74	748	10	control	control	NN
cord-015021-pol2qm74	748	11	(	(	-LRB-
cord-015021-pol2qm74	748	12	n=3	n=3	NN
cord-015021-pol2qm74	748	13	)	)	-RRB-
cord-015021-pol2qm74	748	14	and	and	CC
cord-015021-pol2qm74	748	15	two	two	CD
cord-015021-pol2qm74	748	16	experimental	experimental	JJ
cord-015021-pol2qm74	748	17	(	(	-LRB-
cord-015021-pol2qm74	748	18	n=6	n=6	JJ
cord-015021-pol2qm74	748	19	each	each	DT
cord-015021-pol2qm74	748	20	)	)	-RRB-
cord-015021-pol2qm74	748	21	.	.	.
cord-015021-pol2qm74	749	1	A	a	DT
cord-015021-pol2qm74	749	2	portal	portal	JJ
cord-015021-pol2qm74	749	3	vein	vein	NN
cord-015021-pol2qm74	749	4	catheter	catheter	NN
cord-015021-pol2qm74	749	5	was	be	VBD
cord-015021-pol2qm74	749	6	placed	place	VBN
cord-015021-pol2qm74	749	7	and	and	CC
cord-015021-pol2qm74	749	8	remained	remain	VBN
cord-015021-pol2qm74	749	9	in	in	IN
cord-015021-pol2qm74	749	10	situ	situ	NN
cord-015021-pol2qm74	749	11	48	48	CD
cord-015021-pol2qm74	749	12	hrs	hrs	NN
cord-015021-pol2qm74	749	13	.	.	.
cord-015021-pol2qm74	750	1	A	a	DT
cord-015021-pol2qm74	750	2	femoral	femoral	JJ
cord-015021-pol2qm74	750	3	artery	artery	NN
cord-015021-pol2qm74	750	4	and	and	CC
cord-015021-pol2qm74	750	5	vein	vein	NN
cord-015021-pol2qm74	750	6	catheter	catheter	NN
cord-015021-pol2qm74	750	7	were	be	VBD
cord-015021-pol2qm74	750	8	in	in	IN
cord-015021-pol2qm74	750	9	place	place	NN
cord-015021-pol2qm74	750	10	12	12	CD
cord-015021-pol2qm74	750	11	hrs	hrs	NN
cord-015021-pol2qm74	750	12	.	.	.
cord-015021-pol2qm74	751	1	The	the	DT
cord-015021-pol2qm74	751	2	arterial	arterial	JJ
cord-015021-pol2qm74	751	3	eaanula	eaanula	NN
cord-015021-pol2qm74	751	4	was	be	VBD
cord-015021-pol2qm74	751	5	used	use	VBN
cord-015021-pol2qm74	751	6	for	for	IN
cord-015021-pol2qm74	751	7	monitoring	monitor	VBG
cord-015021-pol2qm74	751	8	mean	mean	JJ
cord-015021-pol2qm74	751	9	arterial	arterial	JJ
cord-015021-pol2qm74	751	10	pressure	pressure	NN
cord-015021-pol2qm74	751	11	(	(	-LRB-
cord-015021-pol2qm74	751	12	MAP	MAP	NNP
cord-015021-pol2qm74	751	13	)	)	-RRB-
cord-015021-pol2qm74	751	14	in	in	IN
cord-015021-pol2qm74	751	15	all	all	DT
cord-015021-pol2qm74	751	16	animals	animal	NNS
cord-015021-pol2qm74	751	17	and	and	CC
cord-015021-pol2qm74	751	18	to	to	TO
cord-015021-pol2qm74	751	19	bleed	bleed	VB
cord-015021-pol2qm74	751	20	the	the	DT
cord-015021-pol2qm74	751	21	experimental	experimental	JJ
cord-015021-pol2qm74	751	22	animals	animal	NNS
cord-015021-pol2qm74	751	23	and	and	CC
cord-015021-pol2qm74	751	24	the	the	DT
cord-015021-pol2qm74	751	25	venous	venous	JJ
cord-015021-pol2qm74	751	26	cannula	cannula	NN
cord-015021-pol2qm74	751	27	to	to	IN
cord-015021-pol2qm74	751	28	repelfuse	repelfuse	NNP
cord-015021-pol2qm74	751	29	with	with	IN
cord-015021-pol2qm74	751	30	Ringer	Ringer	NNP
cord-015021-pol2qm74	751	31	's	's	POS
cord-015021-pol2qm74	751	32	lactate	lactate	NN
cord-015021-pol2qm74	751	33	(	(	-LRB-
cord-015021-pol2qm74	751	34	RL	RL	NNP
cord-015021-pol2qm74	751	35	)	)	-RRB-
cord-015021-pol2qm74	751	36	or	or	CC
cord-015021-pol2qm74	751	37	autologous	autologous	JJ
cord-015021-pol2qm74	751	38	blood	blood	NN
cord-015021-pol2qm74	751	39	(	(	-LRB-
cord-015021-pol2qm74	751	40	AB	AB	NNP
cord-015021-pol2qm74	751	41	)	)	-RRB-
cord-015021-pol2qm74	751	42	.	.	.
cord-015021-pol2qm74	752	1	Baseline	baseline	JJ
cord-015021-pol2qm74	752	2	samples	sample	NNS
cord-015021-pol2qm74	752	3	and	and	CC
cord-015021-pol2qm74	752	4	values	value	NNS
cord-015021-pol2qm74	752	5	were	be	VBD
cord-015021-pol2qm74	752	6	taken	take	VBN
cord-015021-pol2qm74	752	7	in	in	IN
cord-015021-pol2qm74	752	8	this	this	DT
cord-015021-pol2qm74	752	9	period	period	NN
cord-015021-pol2qm74	752	10	.	.	.
cord-015021-pol2qm74	753	1	Control	control	NN
cord-015021-pol2qm74	753	2	animals	animal	NNS
cord-015021-pol2qm74	753	3	were	be	VBD
cord-015021-pol2qm74	753	4	observed	observe	VBN
cord-015021-pol2qm74	753	5	for	for	IN
cord-015021-pol2qm74	753	6	a	a	DT
cord-015021-pol2qm74	753	7	sham	sham	JJ
cord-015021-pol2qm74	753	8	shock	shock	NN
cord-015021-pol2qm74	753	9	period	period	NN
cord-015021-pol2qm74	753	10	of	of	IN
cord-015021-pol2qm74	753	11	6.5	6.5	CD
cord-015021-pol2qm74	753	12	hrs	hrs	NN
cord-015021-pol2qm74	753	13	.	.	.
cord-015021-pol2qm74	753	14	,	,	,
cord-015021-pol2qm74	753	15	given	give	VBN
cord-015021-pol2qm74	753	16	2	2	CD
cord-015021-pol2qm74	753	17	more	more	JJR
cord-015021-pol2qm74	753	18	hours	hour	NNS
cord-015021-pol2qm74	753	19	of	of	IN
cord-015021-pol2qm74	753	20	anesthesia	anesthesia	NN
cord-015021-pol2qm74	753	21	,	,	,
cord-015021-pol2qm74	753	22	and	and	CC
cord-015021-pol2qm74	753	23	studied	study	VBD
cord-015021-pol2qm74	753	24	for	for	IN
cord-015021-pol2qm74	753	25	further	further	JJ
cord-015021-pol2qm74	753	26	48	48	CD
cord-015021-pol2qm74	753	27	hrs	hrs	NN
cord-015021-pol2qm74	753	28	.	.	.
cord-015021-pol2qm74	754	1	40	40	CD
cord-015021-pol2qm74	754	2	%	%	NN
cord-015021-pol2qm74	754	3	of	of	IN
cord-015021-pol2qm74	754	4	the	the	DT
cord-015021-pol2qm74	754	5	estimated	estimate	VBN
cord-015021-pol2qm74	754	6	blood	blood	NN
cord-015021-pol2qm74	754	7	volume	volume	NN
cord-015021-pol2qm74	754	8	was	be	VBD
cord-015021-pol2qm74	754	9	withdrawn	withdraw	VBN
cord-015021-pol2qm74	754	10	from	from	IN
cord-015021-pol2qm74	754	11	each	each	DT
cord-015021-pol2qm74	754	12	experimental	experimental	JJ
cord-015021-pol2qm74	754	13	animal	animal	NN
cord-015021-pol2qm74	754	14	over	over	IN
cord-015021-pol2qm74	754	15	30	30	CD
cord-015021-pol2qm74	754	16	min	min	NN
cord-015021-pol2qm74	754	17	.	.	.
cord-015021-pol2qm74	755	1	These	these	DT
cord-015021-pol2qm74	755	2	animals	animal	NNS
cord-015021-pol2qm74	755	3	were	be	VBD
cord-015021-pol2qm74	755	4	kept	keep	VBN
cord-015021-pol2qm74	755	5	in	in	IN
cord-015021-pol2qm74	755	6	shock	shock	NN
cord-015021-pol2qm74	755	7	for	for	IN
cord-015021-pol2qm74	755	8	6.5	6.5	CD
cord-015021-pol2qm74	755	9	hrs	hrs	NN
cord-015021-pol2qm74	755	10	.	.	.
cord-015021-pol2qm74	756	1	At	at	IN
cord-015021-pol2qm74	756	2	the	the	DT
cord-015021-pol2qm74	756	3	end	end	NN
cord-015021-pol2qm74	756	4	of	of	IN
cord-015021-pol2qm74	756	5	the	the	DT
cord-015021-pol2qm74	756	6	shock	shock	NN
cord-015021-pol2qm74	756	7	one	one	CD
cord-015021-pol2qm74	756	8	group	group	NN
cord-015021-pol2qm74	756	9	was	be	VBD
cord-015021-pol2qm74	756	10	perfused	perfuse	VBN
cord-015021-pol2qm74	756	11	with	with	IN
cord-015021-pol2qm74	756	12	RL	RL	NNP
cord-015021-pol2qm74	756	13	and	and	CC
cord-015021-pol2qm74	756	14	the	the	DT
cord-015021-pol2qm74	756	15	other	other	JJ
cord-015021-pol2qm74	756	16	with	with	IN
cord-015021-pol2qm74	756	17	AB	AB	NNP
cord-015021-pol2qm74	756	18	.	.	.
cord-015021-pol2qm74	757	1	Two	two	CD
cord-015021-pol2qm74	757	2	hours	hour	NNS
cord-015021-pol2qm74	757	3	later	later	RB
cord-015021-pol2qm74	757	4	they	-PRON-	PRP
cord-015021-pol2qm74	757	5	were	be	VBD
cord-015021-pol2qm74	757	6	extubated	extubate	VBN
cord-015021-pol2qm74	757	7	and	and	CC
cord-015021-pol2qm74	757	8	further	further	RB
cord-015021-pol2qm74	757	9	studied	study	VBN
cord-015021-pol2qm74	757	10	for	for	IN
cord-015021-pol2qm74	757	11	48	48	CD
cord-015021-pol2qm74	757	12	hrs	hrs	NN
cord-015021-pol2qm74	757	13	.	.	.
cord-015021-pol2qm74	758	1	Samples	sample	NNS
cord-015021-pol2qm74	758	2	from	from	IN
cord-015021-pol2qm74	758	3	portal	portal	JJ
cord-015021-pol2qm74	758	4	blood	blood	NN
cord-015021-pol2qm74	758	5	for	for	IN
cord-015021-pol2qm74	758	6	cultures	culture	NNS
cord-015021-pol2qm74	758	7	and	and	CC
cord-015021-pol2qm74	758	8	measurement	measurement	NN
cord-015021-pol2qm74	758	9	of	of	IN
cord-015021-pol2qm74	758	10	Leukotriene	Leukotriene	NNP
cord-015021-pol2qm74	758	11	B4	B4	NNP
cord-015021-pol2qm74	758	12	(	(	-LRB-
cord-015021-pol2qm74	758	13	LTB4	LTB4	NNP
cord-015021-pol2qm74	758	14	)	)	-RRB-
cord-015021-pol2qm74	758	15	,	,	,
cord-015021-pol2qm74	758	16	Prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	758	17	E2	E2	NNP
cord-015021-pol2qm74	758	18	(	(	-LRB-
cord-015021-pol2qm74	758	19	PGE2	PGE2	NNP
cord-015021-pol2qm74	758	20	)	)	-RRB-
cord-015021-pol2qm74	758	21	,	,	,
cord-015021-pol2qm74	758	22	and	and	CC
cord-015021-pol2qm74	758	23	nitric	nitric	NN
cord-015021-pol2qm74	758	24	oxide	oxide	NN
cord-015021-pol2qm74	759	1	(	(	-LRB-
cord-015021-pol2qm74	759	2	NO	no	UH
cord-015021-pol2qm74	759	3	)	)	-RRB-
cord-015021-pol2qm74	759	4	metabolites	metabolite	NNS
cord-015021-pol2qm74	759	5	were	be	VBD
cord-015021-pol2qm74	759	6	taken	take	VBN
cord-015021-pol2qm74	759	7	from	from	IN
cord-015021-pol2qm74	759	8	all	all	DT
cord-015021-pol2qm74	759	9	animals	animal	NNS
cord-015021-pol2qm74	759	10	at	at	IN
cord-015021-pol2qm74	759	11	intervals	interval	NNS
cord-015021-pol2qm74	759	12	beyond	beyond	IN
cord-015021-pol2qm74	759	13	baseline	baseline	NN
cord-015021-pol2qm74	759	14	up	up	IN
cord-015021-pol2qm74	759	15	to	to	IN
cord-015021-pol2qm74	759	16	48	48	CD
cord-015021-pol2qm74	759	17	hrs	hrs	NN
cord-015021-pol2qm74	759	18	.	.	.
cord-015021-pol2qm74	760	1	After	after	IN
cord-015021-pol2qm74	760	2	48	48	CD
cord-015021-pol2qm74	760	3	hrs	hrs	NN
cord-015021-pol2qm74	760	4	.	.	.
cord-015021-pol2qm74	761	1	under	under	IN
cord-015021-pol2qm74	761	2	general	general	JJ
cord-015021-pol2qm74	761	3	anesthesia	anesthesia	NNP
cord-015021-pol2qm74	761	4	a	a	DT
cord-015021-pol2qm74	761	5	second	second	JJ
cord-015021-pol2qm74	761	6	laparotomy	laparotomy	NN
cord-015021-pol2qm74	761	7	was	be	VBD
cord-015021-pol2qm74	761	8	performed	perform	VBN
cord-015021-pol2qm74	761	9	and	and	CC
cord-015021-pol2qm74	761	10	samples	sample	NNS
cord-015021-pol2qm74	761	11	for	for	IN
cord-015021-pol2qm74	761	12	culture	culture	NN
cord-015021-pol2qm74	761	13	from	from	IN
cord-015021-pol2qm74	761	14	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	761	15	lymph	lymph	NN
cord-015021-pol2qm74	761	16	nodes	node	NNS
cord-015021-pol2qm74	761	17	(	(	-LRB-
cord-015021-pol2qm74	761	18	MIN	MIN	NNP
cord-015021-pol2qm74	761	19	)	)	-RRB-
cord-015021-pol2qm74	761	20	,	,	,
cord-015021-pol2qm74	761	21	liver	liver	NN
cord-015021-pol2qm74	761	22	and	and	CC
cord-015021-pol2qm74	761	23	spleen	spleen	NNS
cord-015021-pol2qm74	761	24	were	be	VBD
cord-015021-pol2qm74	761	25	taken	take	VBN
cord-015021-pol2qm74	761	26	;	;	:
cord-015021-pol2qm74	761	27	as	as	RB
cord-015021-pol2qm74	761	28	well	well	RB
cord-015021-pol2qm74	761	29	as	as	IN
cord-015021-pol2qm74	761	30	samples	sample	NNS
cord-015021-pol2qm74	761	31	for	for	IN
cord-015021-pol2qm74	761	32	histologic	histologic	JJ
cord-015021-pol2qm74	761	33	study	study	NN
cord-015021-pol2qm74	761	34	with	with	IN
cord-015021-pol2qm74	761	35	light	light	JJ
cord-015021-pol2qm74	761	36	and	and	CC
cord-015021-pol2qm74	761	37	scanning	scanning	NN
cord-015021-pol2qm74	761	38	electron	electron	NN
cord-015021-pol2qm74	761	39	microscopy	microscopy	NNS
cord-015021-pol2qm74	761	40	were	be	VBD
cord-015021-pol2qm74	761	41	taken	take	VBN
cord-015021-pol2qm74	761	42	from	from	IN
cord-015021-pol2qm74	761	43	jejunum	jejunum	NN
cord-015021-pol2qm74	761	44	,	,	,
cord-015021-pol2qm74	761	45	ileum	ileum	NN
cord-015021-pol2qm74	761	46	,	,	,
cord-015021-pol2qm74	761	47	and	and	CC
cord-015021-pol2qm74	761	48	colon	colon	NN
cord-015021-pol2qm74	761	49	.	.	.
cord-015021-pol2qm74	762	1	Animals	animal	NNS
cord-015021-pol2qm74	762	2	were	be	VBD
cord-015021-pol2qm74	762	3	then	then	RB
cord-015021-pol2qm74	762	4	euthanized	euthanize	VBN
cord-015021-pol2qm74	762	5	.	.	.
cord-015021-pol2qm74	763	1	RESULTS	result	NNS
cord-015021-pol2qm74	763	2	:	:	:
cord-015021-pol2qm74	764	1	significant	significant	JJ
cord-015021-pol2qm74	764	2	shock	shock	NN
cord-015021-pol2qm74	764	3	was	be	VBD
cord-015021-pol2qm74	764	4	induced	induce	VBN
cord-015021-pol2qm74	764	5	as	as	IN
cord-015021-pol2qm74	764	6	indicated	indicate	VBN
cord-015021-pol2qm74	764	7	by	by	IN
cord-015021-pol2qm74	764	8	MAP	map	NN
cord-015021-pol2qm74	764	9	and	and	CC
cord-015021-pol2qm74	764	10	arterial	arterial	JJ
cord-015021-pol2qm74	764	11	blood	blood	NN
cord-015021-pol2qm74	764	12	gases	gas	NNS
cord-015021-pol2qm74	764	13	.	.	.
cord-015021-pol2qm74	765	1	Significant	significant	JJ
cord-015021-pol2qm74	765	2	BT	BT	NNP
cord-015021-pol2qm74	765	3	to	to	IN
cord-015021-pol2qm74	765	4	MIN	MIN	NNP
cord-015021-pol2qm74	765	5	was	be	VBD
cord-015021-pol2qm74	765	6	observed	observe	VBN
cord-015021-pol2qm74	765	7	in	in	IN
cord-015021-pol2qm74	765	8	all	all	DT
cord-015021-pol2qm74	765	9	groups	group	NNS
cord-015021-pol2qm74	765	10	.	.	.
cord-015021-pol2qm74	766	1	No	no	DT
cord-015021-pol2qm74	766	2	significant	significant	JJ
cord-015021-pol2qm74	766	3	BT	BT	NNP
cord-015021-pol2qm74	766	4	was	be	VBD
cord-015021-pol2qm74	766	5	observed	observe	VBN
cord-015021-pol2qm74	766	6	in	in	IN
cord-015021-pol2qm74	766	7	cultures	culture	NNS
cord-015021-pol2qm74	766	8	from	from	IN
cord-015021-pol2qm74	766	9	liver	liver	NN
cord-015021-pol2qm74	766	10	and	and	CC
cord-015021-pol2qm74	766	11	spleen	spleen	NNS
cord-015021-pol2qm74	766	12	in	in	IN
cord-015021-pol2qm74	766	13	any	any	DT
cord-015021-pol2qm74	766	14	of	of	IN
cord-015021-pol2qm74	766	15	the	the	DT
cord-015021-pol2qm74	766	16	groups	group	NNS
cord-015021-pol2qm74	766	17	.	.	.
cord-015021-pol2qm74	767	1	Increased	increase	VBN
cord-015021-pol2qm74	767	2	values	value	NNS
cord-015021-pol2qm74	767	3	for	for	IN
cord-015021-pol2qm74	767	4	LTB4	LTB4	NNP
cord-015021-pol2qm74	767	5	,	,	,
cord-015021-pol2qm74	767	6	PGE2	PGE2	NNP
cord-015021-pol2qm74	767	7	and	and	CC
cord-015021-pol2qm74	767	8	NO	no	DT
cord-015021-pol2qm74	767	9	metabolites	metabolite	NNS
cord-015021-pol2qm74	767	10	were	be	VBD
cord-015021-pol2qm74	767	11	found	find	VBN
cord-015021-pol2qm74	767	12	during	during	IN
cord-015021-pol2qm74	767	13	the	the	DT
cord-015021-pol2qm74	767	14	period	period	NN
cord-015021-pol2qm74	767	15	of	of	IN
cord-015021-pol2qm74	767	16	shock	shock	NN
cord-015021-pol2qm74	767	17	.	.	.
cord-015021-pol2qm74	768	1	These	these	DT
cord-015021-pol2qm74	768	2	results	result	NNS
cord-015021-pol2qm74	768	3	suggest	suggest	VBP
cord-015021-pol2qm74	768	4	that	that	IN
cord-015021-pol2qm74	768	5	the	the	DT
cord-015021-pol2qm74	768	6	isehemic	isehemic	JJ
cord-015021-pol2qm74	768	7	phenomenon	phenomenon	NN
cord-015021-pol2qm74	768	8	triggers	trigger	VBZ
cord-015021-pol2qm74	768	9	a	a	DT
cord-015021-pol2qm74	768	10	significant	significant	JJ
cord-015021-pol2qm74	768	11	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	768	12	response	response	NN
cord-015021-pol2qm74	768	13	,	,	,
cord-015021-pol2qm74	768	14	and	and	CC
cord-015021-pol2qm74	768	15	that	that	IN
cord-015021-pol2qm74	768	16	BT	BT	NNP
cord-015021-pol2qm74	768	17	to	to	IN
cord-015021-pol2qm74	768	18	MIN	MIN	NNP
cord-015021-pol2qm74	768	19	may	may	MD
cord-015021-pol2qm74	768	20	be	be	VB
cord-015021-pol2qm74	768	21	an	an	DT
cord-015021-pol2qm74	768	22	epiphenomenon	epiphenomenon	NN
cord-015021-pol2qm74	768	23	without	without	IN
cord-015021-pol2qm74	768	24	apparent	apparent	JJ
cord-015021-pol2qm74	768	25	significant	significant	JJ
cord-015021-pol2qm74	768	26	influence	influence	NN
cord-015021-pol2qm74	768	27	on	on	IN
cord-015021-pol2qm74	768	28	the	the	DT
cord-015021-pol2qm74	768	29	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	768	30	response	response	NN
cord-015021-pol2qm74	768	31	.	.	.
cord-015021-pol2qm74	769	1	Objective	objective	NN
cord-015021-pol2qm74	769	2	:	:	:
cord-015021-pol2qm74	769	3	To	to	TO
cord-015021-pol2qm74	769	4	study	study	VB
cord-015021-pol2qm74	769	5	the	the	DT
cord-015021-pol2qm74	769	6	potential	potential	JJ
cord-015021-pol2qm74	769	7	effects	effect	NNS
cord-015021-pol2qm74	769	8	and	and	CC
cord-015021-pol2qm74	769	9	mechanisms	mechanism	NNS
cord-015021-pol2qm74	769	10	of	of	IN
cord-015021-pol2qm74	769	11	action	action	NN
cord-015021-pol2qm74	769	12	of	of	IN
cord-015021-pol2qm74	769	13	systemic	systemic	JJ
cord-015021-pol2qm74	769	14	administration	administration	NN
cord-015021-pol2qm74	769	15	of	of	IN
cord-015021-pol2qm74	769	16	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	769	17	antibodies	antibody	NNS
cord-015021-pol2qm74	769	18	anti	anti	JJ
cord-015021-pol2qm74	769	19	-	-	JJ
cord-015021-pol2qm74	769	20	endotoxin	endotoxin	JJ
cord-015021-pol2qm74	769	21	(	(	-LRB-
cord-015021-pol2qm74	769	22	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	769	23	)	)	-RRB-
cord-015021-pol2qm74	769	24	in	in	IN
cord-015021-pol2qm74	769	25	a	a	DT
cord-015021-pol2qm74	769	26	animal	animal	NN
cord-015021-pol2qm74	769	27	model	model	NN
cord-015021-pol2qm74	769	28	of	of	IN
cord-015021-pol2qm74	769	29	gut	gut	NN
cord-015021-pol2qm74	769	30	-	-	HYPH
cord-015021-pol2qm74	769	31	origin	origin	NN
cord-015021-pol2qm74	769	32	sepsis	sepsis	NN
cord-015021-pol2qm74	769	33	.	.	.
cord-015021-pol2qm74	770	1	Materials	material	NNS
cord-015021-pol2qm74	770	2	and	and	CC
cord-015021-pol2qm74	770	3	Methods	method	NNS
cord-015021-pol2qm74	770	4	:	:	:
cord-015021-pol2qm74	770	5	Exoeriment	Exoeriment	NNP
cord-015021-pol2qm74	770	6	A.	a.	NN
cord-015021-pol2qm74	771	1	BALB	BALB	NNP
cord-015021-pol2qm74	771	2	/	/	SYM
cord-015021-pol2qm74	771	3	c	c	NN
cord-015021-pol2qm74	771	4	mice	mouse	NNS
cord-015021-pol2qm74	771	5	were	be	VBD
cord-015021-pol2qm74	771	6	transfused	transfuse	VBN
cord-015021-pol2qm74	771	7	with	with	IN
cord-015021-pol2qm74	771	8	allogeneic	allogeneic	NN
cord-015021-pol2qm74	771	9	blood	blood	NN
cord-015021-pol2qm74	771	10	(	(	-LRB-
cord-015021-pol2qm74	771	11	from	from	IN
cord-015021-pol2qm74	771	12	C3HB	C3HB	NNP
cord-015021-pol2qm74	771	13	-	-	HYPH
cord-015021-pol2qm74	771	14	IeJ	IeJ	NNP
cord-015021-pol2qm74	771	15	mice	mouse	NNS
cord-015021-pol2qm74	771	16	)	)	-RRB-
cord-015021-pol2qm74	771	17	.	.	.
cord-015021-pol2qm74	772	1	Five	five	CD
cord-015021-pol2qm74	772	2	days	day	NNS
cord-015021-pol2qm74	772	3	post	post	NN
cord-015021-pol2qm74	772	4	-	-	JJ
cord-015021-pol2qm74	772	5	transfusion	transfusion	NN
cord-015021-pol2qm74	772	6	the	the	DT
cord-015021-pol2qm74	772	7	animals	animal	NNS
cord-015021-pol2qm74	772	8	were	be	VBD
cord-015021-pol2qm74	772	9	gavaged	gavage	VBN
cord-015021-pol2qm74	772	10	with	with	IN
cord-015021-pol2qm74	772	11	lxl09	lxl09	``
cord-015021-pol2qm74	772	12	viable	viable	JJ
cord-015021-pol2qm74	772	13	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	772	14	coil	coil	NN
cord-015021-pol2qm74	772	15	and	and	CC
cord-015021-pol2qm74	772	16	randomized	randomize	VBD
cord-015021-pol2qm74	772	17	into	into	IN
cord-015021-pol2qm74	772	18	3	3	CD
cord-015021-pol2qm74	772	19	groups	group	NNS
cord-015021-pol2qm74	772	20	(	(	-LRB-
cord-015021-pol2qm74	772	21	n=22	n=22	NNP
cord-015021-pol2qm74	772	22	/	/	SYM
cord-015021-pol2qm74	772	23	group	group	NN
cord-015021-pol2qm74	772	24	)	)	-RRB-
cord-015021-pol2qm74	772	25	to	to	TO
cord-015021-pol2qm74	772	26	receive	receive	VB
cord-015021-pol2qm74	772	27	a	a	DT
cord-015021-pol2qm74	772	28	sham	sham	JJ
cord-015021-pol2qm74	772	29	burn	burn	NN
cord-015021-pol2qm74	772	30	(	(	-LRB-
cord-015021-pol2qm74	772	31	SB	SB	NNP
cord-015021-pol2qm74	772	32	group	group	NN
cord-015021-pol2qm74	772	33	)	)	-RRB-
cord-015021-pol2qm74	772	34	or	or	CC
cord-015021-pol2qm74	772	35	a	a	DT
cord-015021-pol2qm74	772	36	20	20	CD
cord-015021-pol2qm74	772	37	%	%	NN
cord-015021-pol2qm74	772	38	thermal	thermal	JJ
cord-015021-pol2qm74	772	39	injury	injury	NN
cord-015021-pol2qm74	772	40	immediately	immediately	RB
cord-015021-pol2qm74	772	41	followed	follow	VBD
cord-015021-pol2qm74	772	42	by	by	IN
cord-015021-pol2qm74	772	43	the	the	DT
cord-015021-pol2qm74	772	44	systemic	systemic	JJ
cord-015021-pol2qm74	772	45	administration	administration	NN
cord-015021-pol2qm74	772	46	,	,	,
cord-015021-pol2qm74	772	47	via	via	IN
cord-015021-pol2qm74	772	48	a	a	DT
cord-015021-pol2qm74	772	49	tail	tail	NN
cord-015021-pol2qm74	772	50	vein	vein	NN
cord-015021-pol2qm74	772	51	,	,	,
cord-015021-pol2qm74	772	52	of	of	IN
cord-015021-pol2qm74	772	53	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	772	54	antibodies	antibody	NNS
cord-015021-pol2qm74	772	55	(	(	-LRB-
cord-015021-pol2qm74	772	56	6	6	CD
cord-015021-pol2qm74	772	57	mg	mg	NNP
cord-015021-pol2qm74	772	58	/	/	SYM
cord-015021-pol2qm74	772	59	kg	kg	NNP
cord-015021-pol2qm74	772	60	)	)	-RRB-
cord-015021-pol2qm74	772	61	(	(	-LRB-
cord-015021-pol2qm74	772	62	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	772	63	group	group	NN
cord-015021-pol2qm74	772	64	)	)	-RRB-
cord-015021-pol2qm74	772	65	or	or	CC
cord-015021-pol2qm74	772	66	a	a	DT
cord-015021-pol2qm74	772	67	20	20	CD
cord-015021-pol2qm74	772	68	%	%	NN
cord-015021-pol2qm74	772	69	burn	burn	NN
cord-015021-pol2qm74	772	70	injury	injury	NN
cord-015021-pol2qm74	772	71	and	and	CC
cord-015021-pol2qm74	772	72	administration	administration	NN
cord-015021-pol2qm74	772	73	of	of	IN
cord-015021-pol2qm74	772	74	equal	equal	JJ
cord-015021-pol2qm74	772	75	volume	volume	NN
cord-015021-pol2qm74	772	76	of	of	IN
cord-015021-pol2qm74	772	77	sterile	sterile	JJ
cord-015021-pol2qm74	772	78	saline	saline	NN
cord-015021-pol2qm74	772	79	(	(	-LRB-
cord-015021-pol2qm74	772	80	C	C	NNP
cord-015021-pol2qm74	772	81	group	group	NN
cord-015021-pol2qm74	772	82	)	)	-RRB-
cord-015021-pol2qm74	772	83	.	.	.
cord-015021-pol2qm74	773	1	All	all	DT
cord-015021-pol2qm74	773	2	3	3	CD
cord-015021-pol2qm74	773	3	groups	group	NNS
cord-015021-pol2qm74	773	4	were	be	VBD
cord-015021-pol2qm74	773	5	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	773	6	by	by	IN
cord-015021-pol2qm74	773	7	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	773	8	injection	injection	NN
cord-015021-pol2qm74	773	9	of	of	IN
cord-015021-pol2qm74	773	10	0.3	0.3	CD
cord-015021-pol2qm74	773	11	ml	ml	NNS
cord-015021-pol2qm74	773	12	of	of	IN
cord-015021-pol2qm74	773	13	saline	saline	NN
cord-015021-pol2qm74	773	14	.	.	.
cord-015021-pol2qm74	774	1	The	the	DT
cord-015021-pol2qm74	774	2	animal	animal	NN
cord-015021-pol2qm74	774	3	survival	survival	NN
cord-015021-pol2qm74	774	4	rate	rate	NN
cord-015021-pol2qm74	774	5	was	be	VBD
cord-015021-pol2qm74	774	6	observed	observe	VBN
cord-015021-pol2qm74	774	7	for	for	IN
cord-015021-pol2qm74	774	8	10	10	CD
cord-015021-pol2qm74	774	9	days	day	NNS
cord-015021-pol2qm74	774	10	post	post	NN
cord-015021-pol2qm74	774	11	-	-	JJ
cord-015021-pol2qm74	774	12	burn	burn	JJ
cord-015021-pol2qm74	774	13	.	.	.
cord-015021-pol2qm74	775	1	Experiment	experiment	NN
cord-015021-pol2qm74	775	2	B	B	NNP
cord-015021-pol2qm74	775	3	,	,	,
cord-015021-pol2qm74	775	4	Transfusion	transfusion	NN
cord-015021-pol2qm74	775	5	and	and	CC
cord-015021-pol2qm74	775	6	burn	burn	NN
cord-015021-pol2qm74	775	7	procedures	procedure	NNS
cord-015021-pol2qm74	775	8	were	be	VBD
cord-015021-pol2qm74	775	9	identical	identical	JJ
cord-015021-pol2qm74	775	10	to	to	TO
cord-015021-pol2qm74	775	11	experiment	experiment	VB
cord-015021-pol2qm74	775	12	A	a	DT
cord-015021-pol2qm74	776	1	but	but	CC
cord-015021-pol2qm74	776	2	the	the	DT
cord-015021-pol2qm74	776	3	mice	mouse	NNS
cord-015021-pol2qm74	776	4	(	(	-LRB-
cord-015021-pol2qm74	776	5	n=8	n=8	NN
cord-015021-pol2qm74	776	6	/	/	SYM
cord-015021-pol2qm74	776	7	group	group	NN
cord-015021-pol2qm74	776	8	)	)	-RRB-
cord-015021-pol2qm74	776	9	were	be	VBD
cord-015021-pol2qm74	776	10	gavaged	gavage	VBN
cord-015021-pol2qm74	776	11	with	with	IN
cord-015021-pol2qm74	776	12	109	109	CD
cord-015021-pol2qm74	776	13	viable	viable	JJ
cord-015021-pol2qm74	776	14	E.coli	E.coli	NNS
cord-015021-pol2qm74	776	15	labeled	label	VBN
cord-015021-pol2qm74	776	16	with	with	IN
cord-015021-pol2qm74	776	17	mMndium	mMndium	NNP
cord-015021-pol2qm74	776	18	oxine	oxine	NN
cord-015021-pol2qm74	776	19	.	.	.
cord-015021-pol2qm74	777	1	Four	four	CD
cord-015021-pol2qm74	777	2	hours	hour	NNS
cord-015021-pol2qm74	777	3	after	after	IN
cord-015021-pol2qm74	777	4	burn	burn	VBP
cord-015021-pol2qm74	777	5	the	the	DT
cord-015021-pol2qm74	777	6	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	777	7	lymph	lymph	NN
cord-015021-pol2qm74	777	8	nodes	node	NNS
cord-015021-pol2qm74	777	9	(	(	-LRB-
cord-015021-pol2qm74	777	10	MLN	mln	NN
cord-015021-pol2qm74	777	11	)	)	-RRB-
cord-015021-pol2qm74	777	12	,	,	,
cord-015021-pol2qm74	777	13	liver	liver	NN
cord-015021-pol2qm74	777	14	,	,	,
cord-015021-pol2qm74	777	15	lungs	lung	NNS
cord-015021-pol2qm74	777	16	and	and	CC
cord-015021-pol2qm74	777	17	blood	blood	NN
cord-015021-pol2qm74	777	18	were	be	VBD
cord-015021-pol2qm74	777	19	harvested	harvest	VBN
cord-015021-pol2qm74	777	20	to	to	TO
cord-015021-pol2qm74	777	21	determine	determine	VB
cord-015021-pol2qm74	777	22	plasma	plasma	NN
cord-015021-pol2qm74	777	23	endotoxin	endotoxin	NN
cord-015021-pol2qm74	777	24	levels	level	NNS
cord-015021-pol2qm74	777	25	and	and	CC
cord-015021-pol2qm74	777	26	the	the	DT
cord-015021-pol2qm74	777	27	magnitude	magnitude	NN
cord-015021-pol2qm74	777	28	of	of	IN
cord-015021-pol2qm74	777	29	transtocation	transtocation	NN
cord-015021-pol2qm74	777	30	of	of	IN
cord-015021-pol2qm74	777	31	labeled	label	VBN
cord-015021-pol2qm74	777	32	bacteria	bacteria	NNS
cord-015021-pol2qm74	777	33	as	as	IN
cord-015021-pol2qm74	777	34	measured	measure	VBN
cord-015021-pol2qm74	777	35	by	by	IN
cord-015021-pol2qm74	777	36	the	the	DT
cord-015021-pol2qm74	777	37	residual	residual	JJ
cord-015021-pol2qm74	777	38	radioactivity	radioactivity	NN
cord-015021-pol2qm74	777	39	(	(	-LRB-
cord-015021-pol2qm74	777	40	dpm	dpm	NNP
cord-015021-pol2qm74	777	41	)	)	-RRB-
cord-015021-pol2qm74	777	42	in	in	IN
cord-015021-pol2qm74	777	43	the	the	DT
cord-015021-pol2qm74	777	44	organs	organ	NNS
cord-015021-pol2qm74	777	45	.	.	.
cord-015021-pol2qm74	778	1	Circulating	circulate	VBG
cord-015021-pol2qm74	778	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	778	3	levels	level	NNS
cord-015021-pol2qm74	778	4	were	be	VBD
cord-015021-pol2qm74	778	5	determined	determine	VBN
cord-015021-pol2qm74	778	6	by	by	IN
cord-015021-pol2qm74	778	7	limulus	limulus	NNP
cord-015021-pol2qm74	778	8	colorimetric	colorimetric	JJ
cord-015021-pol2qm74	778	9	assay	assay	NN
cord-015021-pol2qm74	778	10	.	.	.
cord-015021-pol2qm74	779	1	Diamine	diamine	NN
cord-015021-pol2qm74	779	2	0xidae(DAO	0xidae(DAO	.
cord-015021-pol2qm74	779	3	)	)	-RRB-
cord-015021-pol2qm74	779	4	is	be	VBZ
cord-015021-pol2qm74	779	5	an	an	DT
cord-015021-pol2qm74	779	6	enzyme	enzyme	NN
cord-015021-pol2qm74	779	7	existing	exist	VBG
cord-015021-pol2qm74	779	8	in	in	IN
cord-015021-pol2qm74	779	9	the	the	DT
cord-015021-pol2qm74	779	10	mucosa	mucosa	NN
cord-015021-pol2qm74	779	11	of	of	IN
cord-015021-pol2qm74	779	12	small	small	JJ
cord-015021-pol2qm74	779	13	intestines	intestine	NNS
cord-015021-pol2qm74	779	14	,	,	,
cord-015021-pol2qm74	779	15	but	but	CC
cord-015021-pol2qm74	779	16	its	-PRON-	PRP$
cord-015021-pol2qm74	779	17	activity	activity	NN
cord-015021-pol2qm74	779	18	is	be	VBZ
cord-015021-pol2qm74	779	19	low	low	JJ
cord-015021-pol2qm74	779	20	in	in	IN
cord-015021-pol2qm74	779	21	the	the	DT
cord-015021-pol2qm74	779	22	plasma	plasma	NN
cord-015021-pol2qm74	779	23	.	.	.
cord-015021-pol2qm74	780	1	It	-PRON-	PRP
cord-015021-pol2qm74	780	2	is	be	VBZ
cord-015021-pol2qm74	780	3	evoked	evoke	VBN
cord-015021-pol2qm74	780	4	in	in	IN
cord-015021-pol2qm74	780	5	the	the	DT
cord-015021-pol2qm74	780	6	blood	blood	NN
cord-015021-pol2qm74	780	7	with	with	IN
cord-015021-pol2qm74	780	8	the	the	DT
cord-015021-pol2qm74	780	9	intravenous	intravenous	JJ
cord-015021-pol2qm74	780	10	injection	injection	NN
cord-015021-pol2qm74	780	11	of	of	IN
cord-015021-pol2qm74	780	12	much	much	JJ
cord-015021-pol2qm74	780	13	heparin	heparin	NN
cord-015021-pol2qm74	780	14	.	.	.
cord-015021-pol2qm74	781	1	It	-PRON-	PRP
cord-015021-pol2qm74	781	2	is	be	VBZ
cord-015021-pol2qm74	781	3	well	well	RB
cord-015021-pol2qm74	781	4	known	know	VBN
cord-015021-pol2qm74	781	5	that	that	IN
cord-015021-pol2qm74	781	6	DA0	da0	NN
cord-015021-pol2qm74	781	7	declines	decline	VBZ
cord-015021-pol2qm74	781	8	under	under	IN
cord-015021-pol2qm74	781	9	the	the	DT
cord-015021-pol2qm74	781	10	chronic	chronic	JJ
cord-015021-pol2qm74	781	11	mueosal	mueosal	NN
cord-015021-pol2qm74	781	12	injury	injury	NN
cord-015021-pol2qm74	781	13	when	when	WRB
cord-015021-pol2qm74	781	14	the	the	DT
cord-015021-pol2qm74	781	15	small	small	JJ
cord-015021-pol2qm74	781	16	intestines	intestine	NNS
cord-015021-pol2qm74	781	17	are	be	VBP
cord-015021-pol2qm74	781	18	cut	cut	VBN
cord-015021-pol2qm74	781	19	off	off	RP
cord-015021-pol2qm74	781	20	or	or	CC
cord-015021-pol2qm74	781	21	the	the	DT
cord-015021-pol2qm74	781	22	mucosae	mucosae	NNP
cord-015021-pol2qm74	781	23	become	become	VBN
cord-015021-pol2qm74	781	24	atrophied	atrophied	JJ
cord-015021-pol2qm74	781	25	.	.	.
cord-015021-pol2qm74	782	1	Aim	aim	VB
cord-015021-pol2qm74	782	2	of	of	IN
cord-015021-pol2qm74	782	3	this	this	DT
cord-015021-pol2qm74	782	4	paper	paper	NN
cord-015021-pol2qm74	782	5	is	be	VBZ
cord-015021-pol2qm74	782	6	to	to	TO
cord-015021-pol2qm74	782	7	confirm	confirm	VB
cord-015021-pol2qm74	782	8	that	that	DT
cord-015021-pol2qm74	782	9	DA0	da0	NN
cord-015021-pol2qm74	782	10	goes	go	VBZ
cord-015021-pol2qm74	782	11	up	up	IN
cord-015021-pol2qm74	782	12	to	to	IN
cord-015021-pol2qm74	782	13	the	the	DT
cord-015021-pol2qm74	782	14	measureable	measureable	JJ
cord-015021-pol2qm74	782	15	level	level	NN
cord-015021-pol2qm74	782	16	by	by	IN
cord-015021-pol2qm74	782	17	the	the	DT
cord-015021-pol2qm74	782	18	intravenous	intravenous	JJ
cord-015021-pol2qm74	782	19	injection	injection	NN
cord-015021-pol2qm74	782	20	of	of	IN
cord-015021-pol2qm74	782	21	a	a	DT
cord-015021-pol2qm74	782	22	small	small	JJ
cord-015021-pol2qm74	782	23	amounts	amount	NNS
cord-015021-pol2qm74	782	24	of	of	IN
cord-015021-pol2qm74	782	25	low	low	JJ
cord-015021-pol2qm74	782	26	molecular	molecular	JJ
cord-015021-pol2qm74	782	27	heparin(LMH	heparin(lmh	NN
cord-015021-pol2qm74	782	28	Objectives	objectives	NN
cord-015021-pol2qm74	782	29	:	:	:
cord-015021-pol2qm74	782	30	The	the	DT
cord-015021-pol2qm74	782	31	aims	aim	NNS
cord-015021-pol2qm74	782	32	of	of	IN
cord-015021-pol2qm74	782	33	this	this	DT
cord-015021-pol2qm74	782	34	study	study	NN
cord-015021-pol2qm74	782	35	is	be	VBZ
cord-015021-pol2qm74	782	36	to	to	TO
cord-015021-pol2qm74	782	37	investigate	investigate	VB
cord-015021-pol2qm74	782	38	the	the	DT
cord-015021-pol2qm74	782	39	inhibitor	inhibitor	NN
cord-015021-pol2qm74	782	40	"	"	''
cord-015021-pol2qm74	782	41	effect	effect	NN
cord-015021-pol2qm74	782	42	of	of	IN
cord-015021-pol2qm74	782	43	the	the	DT
cord-015021-pol2qm74	782	44	prolease	prolease	NN
cord-015021-pol2qm74	782	45	inhibitor	inhibitor	NN
cord-015021-pol2qm74	782	46	,	,	,
cord-015021-pol2qm74	782	47	Urinastatin	Urinastatin	NNP
cord-015021-pol2qm74	782	48	,	,	,
cord-015021-pol2qm74	782	49	on	on	IN
cord-015021-pol2qm74	782	50	endotoxin	endotoxin	NN
cord-015021-pol2qm74	782	51	induced	induce	VBN
cord-015021-pol2qm74	782	52	bacterial	bacterial	JJ
cord-015021-pol2qm74	782	53	transleeation	transleeation	NN
cord-015021-pol2qm74	782	54	in	in	IN
cord-015021-pol2qm74	782	55	mice	mouse	NNS
cord-015021-pol2qm74	782	56	.	.	.
cord-015021-pol2qm74	783	1	Materials	material	NNS
cord-015021-pol2qm74	783	2	and	and	CC
cord-015021-pol2qm74	783	3	methods	method	NNS
cord-015021-pol2qm74	783	4	:	:	:
cord-015021-pol2qm74	783	5	lCR	lcr	NN
cord-015021-pol2qm74	783	6	mice	mouse	NNS
cord-015021-pol2qm74	783	7	were	be	VBD
cord-015021-pol2qm74	783	8	divided	divide	VBN
cord-015021-pol2qm74	783	9	in	in	IN
cord-015021-pol2qm74	783	10	six	six	CD
cord-015021-pol2qm74	783	11	groups	group	NNS
cord-015021-pol2qm74	783	12	as	as	IN
cord-015021-pol2qm74	783	13	the	the	DT
cord-015021-pol2qm74	783	14	fotlows	fotlow	NNS
cord-015021-pol2qm74	783	15	,	,	,
cord-015021-pol2qm74	783	16	Group	Group	NNP
cord-015021-pol2qm74	783	17	I	i	NN
cord-015021-pol2qm74	783	18	:	:	:
cord-015021-pol2qm74	783	19	Control	control	NN
cord-015021-pol2qm74	783	20	mice	mouse	NNS
cord-015021-pol2qm74	783	21	receiving	receive	VBG
cord-015021-pol2qm74	783	22	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	783	23	injections	injection	NNS
cord-015021-pol2qm74	783	24	(	(	-LRB-
cord-015021-pol2qm74	783	25	IP	IP	NNP
cord-015021-pol2qm74	783	26	)	)	-RRB-
cord-015021-pol2qm74	783	27	of	of	IN
cord-015021-pol2qm74	783	28	saline	saline	NN
cord-015021-pol2qm74	783	29	24.5	24.5	CD
cord-015021-pol2qm74	783	30	and	and	CC
cord-015021-pol2qm74	783	31	24	24	CD
cord-015021-pol2qm74	783	32	hr	hr	NN
cord-015021-pol2qm74	783	33	prior	prior	RB
cord-015021-pol2qm74	783	34	to	to	IN
cord-015021-pol2qm74	783	35	sacrifice	sacrifice	NN
cord-015021-pol2qm74	783	36	,	,	,
cord-015021-pol2qm74	783	37	Group	Group	NNP
cord-015021-pol2qm74	783	38	Ih	Ih	NNP
cord-015021-pol2qm74	783	39	Treated	treat	VBD
cord-015021-pol2qm74	783	40	mice	mouse	NNS
cord-015021-pol2qm74	783	41	receiving	receive	VBG
cord-015021-pol2qm74	783	42	IP	ip	NN
cord-015021-pol2qm74	783	43	of	of	IN
cord-015021-pol2qm74	783	44	Utinastatin	Utinastatin	NNP
cord-015021-pol2qm74	783	45	24.5	24.5	CD
cord-015021-pol2qm74	783	46	hr	hr	NN
cord-015021-pol2qm74	783	47	and	and	CC
cord-015021-pol2qm74	783	48	endotoxin	endotoxin	NN
cord-015021-pol2qm74	783	49	(	(	-LRB-
cord-015021-pol2qm74	783	50	5mg	5mg	NNP
cord-015021-pol2qm74	783	51	/	/	SYM
cord-015021-pol2qm74	783	52	kg	kg	NN
cord-015021-pol2qm74	783	53	)	)	-RRB-
cord-015021-pol2qm74	784	1	24hr	24hr	JJ
cord-015021-pol2qm74	784	2	prior	prior	RB
cord-015021-pol2qm74	784	3	to	to	IN
cord-015021-pol2qm74	784	4	sacrifice	sacrifice	NN
cord-015021-pol2qm74	784	5	,	,	,
cord-015021-pol2qm74	784	6	Group	Group	NNP
cord-015021-pol2qm74	784	7	Ilk	Ilk	NNP
cord-015021-pol2qm74	784	8	Sham4reated	Sham4reated	NNP
cord-015021-pol2qm74	784	9	mice	mouse	NNS
cord-015021-pol2qm74	784	10	receiving	receive	VBG
cord-015021-pol2qm74	784	11	IP	ip	NN
cord-015021-pol2qm74	784	12	of	of	IN
cord-015021-pol2qm74	784	13	saline	saline	NN
cord-015021-pol2qm74	784	14	24.5	24.5	CD
cord-015021-pol2qm74	784	15	hr	hr	NN
cord-015021-pol2qm74	784	16	and	and	CC
cord-015021-pol2qm74	784	17	endotoxin	endotoxin	NN
cord-015021-pol2qm74	784	18	(	(	-LRB-
cord-015021-pol2qm74	784	19	5mg	5mg	NNP
cord-015021-pol2qm74	784	20	/	/	SYM
cord-015021-pol2qm74	784	21	kg	kg	NN
cord-015021-pol2qm74	785	1	)	)	-RRB-
cord-015021-pol2qm74	785	2	24hr	24hr	RB
cord-015021-pol2qm74	785	3	prior	prior	RB
cord-015021-pol2qm74	785	4	to	to	IN
cord-015021-pol2qm74	785	5	sacrifice	sacrifice	NN
cord-015021-pol2qm74	785	6	,	,	,
cord-015021-pol2qm74	785	7	Group	Group	NNP
cord-015021-pol2qm74	785	8	IV	IV	NNP
cord-015021-pol2qm74	785	9	:	:	:
cord-015021-pol2qm74	785	10	saline	saline	NN
cord-015021-pol2qm74	785	11	control	control	NN
cord-015021-pol2qm74	785	12	mice	mouse	NNS
cord-015021-pol2qm74	785	13	receiving	receive	VBG
cord-015021-pol2qm74	785	14	IP	ip	NN
cord-015021-pol2qm74	785	15	twice	twice	RB
cord-015021-pol2qm74	785	16	during	during	IN
cord-015021-pol2qm74	785	17	30	30	CD
cord-015021-pol2qm74	785	18	rain	rain	NN
cord-015021-pol2qm74	785	19	intervals	interval	NNS
cord-015021-pol2qm74	785	20	,	,	,
cord-015021-pol2qm74	785	21	Group	Group	NNP
cord-015021-pol2qm74	785	22	V	v	NN
cord-015021-pol2qm74	785	23	:	:	:
cord-015021-pol2qm74	785	24	Mice	mouse	NNS
cord-015021-pol2qm74	785	25	received	receive	VBD
cord-015021-pol2qm74	785	26	IP	ip	NN
cord-015021-pol2qm74	785	27	of	of	IN
cord-015021-pol2qm74	785	28	Utinasmtin	Utinasmtin	NNP
cord-015021-pol2qm74	785	29	,	,	,
cord-015021-pol2qm74	785	30	and	and	CC
cord-015021-pol2qm74	785	31	30	30	CD
cord-015021-pol2qm74	785	32	min	min	NN
cord-015021-pol2qm74	785	33	later	later	RB
cord-015021-pol2qm74	785	34	they	-PRON-	PRP
cord-015021-pol2qm74	785	35	were	be	VBD
cord-015021-pol2qm74	785	36	received	receive	VBN
cord-015021-pol2qm74	785	37	IP	ip	NN
cord-015021-pol2qm74	785	38	of	of	IN
cord-015021-pol2qm74	785	39	endotoxin	endotoxin	NN
cord-015021-pol2qm74	785	40	(	(	-LRB-
cord-015021-pol2qm74	785	41	5mg	5mg	NNP
cord-015021-pol2qm74	785	42	/	/	SYM
cord-015021-pol2qm74	785	43	kg	kg	NNP
cord-015021-pol2qm74	785	44	)	)	-RRB-
cord-015021-pol2qm74	785	45	,	,	,
cord-015021-pol2qm74	785	46	Group	Group	NNP
cord-015021-pol2qm74	785	47	VI	VI	NNP
cord-015021-pol2qm74	785	48	:	:	:
cord-015021-pol2qm74	786	1	Mice	mouse	NNS
cord-015021-pol2qm74	786	2	received	receive	VBD
cord-015021-pol2qm74	786	3	IP	ip	NN
cord-015021-pol2qm74	786	4	of	of	IN
cord-015021-pol2qm74	786	5	saline	saline	NN
cord-015021-pol2qm74	786	6	,	,	,
cord-015021-pol2qm74	786	7	and	and	CC
cord-015021-pol2qm74	786	8	30	30	CD
cord-015021-pol2qm74	786	9	min	min	NN
cord-015021-pol2qm74	786	10	later	later	RBR
cord-015021-pol2qm74	786	11	they	-PRON-	PRP
cord-015021-pol2qm74	786	12	received	receive	VBD
cord-015021-pol2qm74	786	13	IP	ip	NN
cord-015021-pol2qm74	786	14	of	of	IN
cord-015021-pol2qm74	786	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	786	16	(	(	-LRB-
cord-015021-pol2qm74	786	17	5mg	5mg	NNP
cord-015021-pol2qm74	786	18	/	/	SYM
cord-015021-pol2qm74	786	19	kg	kg	NNP
cord-015021-pol2qm74	786	20	)	)	-RRB-
cord-015021-pol2qm74	786	21	.	.	.
cord-015021-pol2qm74	787	1	In	in	IN
cord-015021-pol2qm74	787	2	group	group	NN
cord-015021-pol2qm74	787	3	l	l	NN
cord-015021-pol2qm74	787	4	,	,	,
cord-015021-pol2qm74	787	5	II	II	NNP
cord-015021-pol2qm74	787	6	and	and	CC
cord-015021-pol2qm74	787	7	Ill	Ill	NNP
cord-015021-pol2qm74	787	8	,	,	,
cord-015021-pol2qm74	787	9	the	the	DT
cord-015021-pol2qm74	787	10	mice	mouse	NNS
cord-015021-pol2qm74	787	11	were	be	VBD
cord-015021-pol2qm74	787	12	killed	kill	VBN
cord-015021-pol2qm74	787	13	by	by	IN
cord-015021-pol2qm74	787	14	cervical	cervical	JJ
cord-015021-pol2qm74	787	15	dislocation	dislocation	NN
cord-015021-pol2qm74	787	16	.	.	.
cord-015021-pol2qm74	788	1	Using	use	VBG
cord-015021-pol2qm74	788	2	stetile	stetile	JJ
cord-015021-pol2qm74	788	3	techniques	technique	NNS
cord-015021-pol2qm74	788	4	,	,	,
cord-015021-pol2qm74	788	5	a	a	DT
cord-015021-pol2qm74	788	6	middle	middle	JJ
cord-015021-pol2qm74	788	7	-	-	HYPH
cord-015021-pol2qm74	788	8	line	line	NN
cord-015021-pol2qm74	788	9	incision	incision	NN
cord-015021-pol2qm74	788	10	was	be	VBD
cord-015021-pol2qm74	788	11	made	make	VBN
cord-015021-pol2qm74	788	12	and	and	CC
cord-015021-pol2qm74	788	13	the	the	DT
cord-015021-pol2qm74	788	14	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	788	15	lymph	lymph	NN
cord-015021-pol2qm74	788	16	nodes	node	NNS
cord-015021-pol2qm74	788	17	were	be	VBD
cord-015021-pol2qm74	788	18	harvested	harvest	VBN
cord-015021-pol2qm74	788	19	in	in	IN
cord-015021-pol2qm74	788	20	order	order	NN
cord-015021-pol2qm74	788	21	to	to	IN
cord-015021-pol2qm74	788	22	culture	culture	NN
cord-015021-pol2qm74	788	23	on	on	IN
cord-015021-pol2qm74	788	24	selective	selective	JJ
cord-015021-pol2qm74	788	25	agars	agar	NNS
cord-015021-pol2qm74	788	26	for	for	IN
cord-015021-pol2qm74	788	27	quantitation	quantitation	NN
cord-015021-pol2qm74	788	28	of	of	IN
cord-015021-pol2qm74	788	29	bacterial	bacterial	JJ
cord-015021-pol2qm74	788	30	trauslocation	trauslocation	NN
cord-015021-pol2qm74	788	31	.	.	.
cord-015021-pol2qm74	789	1	In	in	IN
cord-015021-pol2qm74	789	2	group	group	NN
cord-015021-pol2qm74	789	3	IV	IV	NNP
cord-015021-pol2qm74	789	4	,	,	,
cord-015021-pol2qm74	789	5	V	v	NN
cord-015021-pol2qm74	789	6	and	and	CC
cord-015021-pol2qm74	789	7	VI	VI	NNP
cord-015021-pol2qm74	789	8	,	,	,
cord-015021-pol2qm74	789	9	survival	survival	NN
cord-015021-pol2qm74	789	10	was	be	VBD
cord-015021-pol2qm74	789	11	recorded	record	VBN
cord-015021-pol2qm74	789	12	for	for	IN
cord-015021-pol2qm74	789	13	3	3	CD
cord-015021-pol2qm74	789	14	days	day	NNS
cord-015021-pol2qm74	789	15	.	.	.
cord-015021-pol2qm74	790	1	Unnastatin	Unnastatin	NNP
cord-015021-pol2qm74	790	2	pretreatment	pretreatment	NN
cord-015021-pol2qm74	790	3	could	could	MD
cord-015021-pol2qm74	790	4	rednce	rednce	VB
cord-015021-pol2qm74	790	5	mortality	mortality	NN
cord-015021-pol2qm74	790	6	significantly	significantly	RB
cord-015021-pol2qm74	790	7	.	.	.
cord-015021-pol2qm74	791	1	First	first	JJ
cord-015021-pol2qm74	791	2	surgey	surgey	NN
cord-015021-pol2qm74	791	3	,	,	,
cord-015021-pol2qm74	791	4	Shiga	Shiga	NNP
cord-015021-pol2qm74	791	5	university	university	NNP
cord-015021-pol2qm74	791	6	of	of	IN
cord-015021-pol2qm74	791	7	medical	medical	JJ
cord-015021-pol2qm74	791	8	science	science	NN
cord-015021-pol2qm74	791	9	,	,	,
cord-015021-pol2qm74	791	10	Seta	Seta	NNP
cord-015021-pol2qm74	791	11	,	,	,
cord-015021-pol2qm74	791	12	Ohtsu	Ohtsu	NNP
cord-015021-pol2qm74	791	13	520	520	CD
cord-015021-pol2qm74	791	14	-	-	HYPH
cord-015021-pol2qm74	791	15	21,Japan	21,japan	JJ
cord-015021-pol2qm74	791	16	Increased	increase	VBN
cord-015021-pol2qm74	791	17	gut	gut	NN
cord-015021-pol2qm74	791	18	permeability	permeability	NN
cord-015021-pol2qm74	791	19	correlates	correlate	VBZ
cord-015021-pol2qm74	791	20	with	with	IN
cord-015021-pol2qm74	791	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	791	22	response	response	NN
cord-015021-pol2qm74	791	23	in	in	IN
cord-015021-pol2qm74	791	24	multiple	multiple	JJ
cord-015021-pol2qm74	791	25	trauma	trauma	NN
cord-015021-pol2qm74	791	26	aptients	aptient	NNS
cord-015021-pol2qm74	791	27	.	.	.
cord-015021-pol2qm74	792	1	Pape	Pape	NNP
cord-015021-pol2qm74	792	2	,	,	,
cord-015021-pol2qm74	792	3	H.-C.	H.-C.	NNP
cord-015021-pol2qm74	792	4	Dwenger	Dwenger	NNP
cord-015021-pol2qm74	792	5	,	,	,
cord-015021-pol2qm74	792	6	A.	A.	NNP
cord-015021-pol2qm74	792	7	Grotz	Grotz	NNP
cord-015021-pol2qm74	792	8	,	,	,
cord-015021-pol2qm74	792	9	M.	M.	NNP
cord-015021-pol2qm74	792	10	Regel	Regel	NNP
cord-015021-pol2qm74	792	11	,	,	,
cord-015021-pol2qm74	792	12	G.	G.	NNP
cord-015021-pol2qm74	792	13	PURPOSE	purpose	NN
cord-015021-pol2qm74	792	14	:	:	:
cord-015021-pol2qm74	793	1	Disturbances	disturbance	NNS
cord-015021-pol2qm74	793	2	of	of	IN
cord-015021-pol2qm74	793	3	intestinal	intestinal	JJ
cord-015021-pol2qm74	793	4	permeability	permeability	NN
cord-015021-pol2qm74	793	5	have	have	VBP
cord-015021-pol2qm74	793	6	been	be	VBN
cord-015021-pol2qm74	793	7	advocated	advocate	VBN
cord-015021-pol2qm74	793	8	as	as	IN
cord-015021-pol2qm74	793	9	a	a	DT
cord-015021-pol2qm74	793	10	pathogenetic	pathogenetic	JJ
cord-015021-pol2qm74	793	11	factor	factor	NN
cord-015021-pol2qm74	793	12	of	of	IN
cord-015021-pol2qm74	793	13	posttranmatic	posttranmatic	JJ
cord-015021-pol2qm74	793	14	multisystem	multisystem	JJ
cord-015021-pol2qm74	793	15	organ	organ	NN
cord-015021-pol2qm74	793	16	failure	failure	NN
cord-015021-pol2qm74	793	17	(	(	-LRB-
cord-015021-pol2qm74	793	18	MOF	MOF	NNP
cord-015021-pol2qm74	793	19	)	)	-RRB-
cord-015021-pol2qm74	793	20	.	.	.
cord-015021-pol2qm74	794	1	A	a	DT
cord-015021-pol2qm74	794	2	close	close	JJ
cord-015021-pol2qm74	794	3	relationship	relationship	NN
cord-015021-pol2qm74	794	4	with	with	IN
cord-015021-pol2qm74	794	5	impairment	impairment	NN
cord-015021-pol2qm74	794	6	of	of	IN
cord-015021-pol2qm74	794	7	the	the	DT
cord-015021-pol2qm74	794	8	stationary	stationary	JJ
cord-015021-pol2qm74	794	9	reticulocndothelial	reticulocndothelial	JJ
cord-015021-pol2qm74	794	10	system	system	NN
cord-015021-pol2qm74	794	11	(	(	-LRB-
cord-015021-pol2qm74	794	12	RES	RES	NNP
cord-015021-pol2qm74	794	13	)	)	-RRB-
cord-015021-pol2qm74	794	14	and	and	CC
cord-015021-pol2qm74	794	15	a	a	DT
cord-015021-pol2qm74	794	16	systemic	systemic	JJ
cord-015021-pol2qm74	794	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	794	18	response	response	NN
cord-015021-pol2qm74	794	19	(	(	-LRB-
cord-015021-pol2qm74	794	20	SIR	SIR	NNP
cord-015021-pol2qm74	794	21	)	)	-RRB-
cord-015021-pol2qm74	794	22	was	be	VBD
cord-015021-pol2qm74	794	23	discussed	discuss	VBN
cord-015021-pol2qm74	794	24	.	.	.
cord-015021-pol2qm74	795	1	These	these	DT
cord-015021-pol2qm74	795	2	tactors	tactor	NNS
cord-015021-pol2qm74	795	3	were	be	VBD
cord-015021-pol2qm74	795	4	investigated	investigate	VBN
cord-015021-pol2qm74	795	5	prospectively	prospectively	RB
cord-015021-pol2qm74	795	6	in	in	IN
cord-015021-pol2qm74	795	7	patients	patient	NNS
cord-015021-pol2qm74	795	8	with	with	IN
cord-015021-pol2qm74	795	9	multiple	multiple	JJ
cord-015021-pol2qm74	795	10	trauma	trauma	NN
cord-015021-pol2qm74	795	11	showing	show	VBG
cord-015021-pol2qm74	795	12	posttraumatie	posttraumatie	NN
cord-015021-pol2qm74	795	13	complications	complication	NNS
cord-015021-pol2qm74	795	14	(	(	-LRB-
cord-015021-pol2qm74	795	15	multiple	multiple	JJ
cord-015021-pol2qm74	795	16	organ	organ	NN
cord-015021-pol2qm74	795	17	failure	failure	NN
cord-015021-pol2qm74	795	18	,	,	,
cord-015021-pol2qm74	795	19	MOF	MOF	NNP
cord-015021-pol2qm74	795	20	)	)	-RRB-
cord-015021-pol2qm74	795	21	.	.	.
cord-015021-pol2qm74	796	1	METHODS	method	NNS
cord-015021-pol2qm74	796	2	:	:	:
cord-015021-pol2qm74	796	3	31	31	CD
cord-015021-pol2qm74	796	4	polytranmatized	polytranmatize	VBN
cord-015021-pol2qm74	796	5	patients	patient	NNS
cord-015021-pol2qm74	796	6	were	be	VBD
cord-015021-pol2qm74	796	7	studied	study	VBN
cord-015021-pol2qm74	796	8	prospectively	prospectively	RB
cord-015021-pol2qm74	796	9	.	.	.
cord-015021-pol2qm74	797	1	According	accord	VBG
cord-015021-pol2qm74	797	2	to	to	IN
cord-015021-pol2qm74	797	3	a	a	DT
cord-015021-pol2qm74	797	4	MOF	MOF	NNP
cord-015021-pol2qm74	797	5	-	-	HYPH
cord-015021-pol2qm74	797	6	score	score	NN
cord-015021-pol2qm74	797	7	(	(	-LRB-
cord-015021-pol2qm74	797	8	GORIS	GORIS	NNP
cord-015021-pol2qm74	797	9	)	)	-RRB-
cord-015021-pol2qm74	798	1	those	those	DT
cord-015021-pol2qm74	798	2	with	with	IN
cord-015021-pol2qm74	798	3	posttrattmatic	posttrattmatic	JJ
cord-015021-pol2qm74	798	4	complications	complication	NNS
cord-015021-pol2qm74	798	5	were	be	VBD
cord-015021-pol2qm74	798	6	selected	select	VBN
cord-015021-pol2qm74	798	7	(	(	-LRB-
cord-015021-pol2qm74	798	8	>	>	NFP
cord-015021-pol2qm74	798	9	7	7	CD
cord-015021-pol2qm74	798	10	points	point	NNS
cord-015021-pol2qm74	798	11	at	at	IN
cord-015021-pol2qm74	798	12	2	2	CD
cord-015021-pol2qm74	798	13	days	day	NNS
cord-015021-pol2qm74	798	14	)	)	-RRB-
cord-015021-pol2qm74	798	15	,	,	,
cord-015021-pol2qm74	798	16	others	other	NNS
cord-015021-pol2qm74	798	17	were	be	VBD
cord-015021-pol2qm74	798	18	excluded	exclude	VBN
cord-015021-pol2qm74	798	19	.	.	.
cord-015021-pol2qm74	799	1	Every	every	DT
cord-015021-pol2qm74	799	2	second	second	JJ
cord-015021-pol2qm74	799	3	day	day	NN
cord-015021-pol2qm74	799	4	gut	gut	NN
cord-015021-pol2qm74	799	5	permeability	permeability	NN
cord-015021-pol2qm74	799	6	according	accord	VBG
cord-015021-pol2qm74	799	7	to	to	IN
cord-015021-pol2qm74	799	8	the	the	DT
cord-015021-pol2qm74	799	9	ratio	ratio	NN
cord-015021-pol2qm74	799	10	of	of	IN
cord-015021-pol2qm74	799	11	urine	urine	NN
cord-015021-pol2qm74	799	12	concentrations	concentration	NNS
cord-015021-pol2qm74	799	13	of	of	IN
cord-015021-pol2qm74	799	14	lactulose	lactulose	NN
cord-015021-pol2qm74	799	15	and	and	CC
cord-015021-pol2qm74	799	16	mannitol	mannitol	NN
cord-015021-pol2qm74	799	17	(	(	-LRB-
cord-015021-pol2qm74	799	18	L	L	NNP
cord-015021-pol2qm74	799	19	/	/	SYM
cord-015021-pol2qm74	799	20	M	M	NNP
cord-015021-pol2qm74	799	21	)	)	-RRB-
cord-015021-pol2qm74	799	22	was	be	VBD
cord-015021-pol2qm74	799	23	evaluated	evaluate	VBN
cord-015021-pol2qm74	799	24	(	(	-LRB-
cord-015021-pol2qm74	799	25	enteral	enteral	JJ
cord-015021-pol2qm74	799	26	application	application	NN
cord-015021-pol2qm74	799	27	)	)	-RRB-
cord-015021-pol2qm74	799	28	.	.	.
cord-015021-pol2qm74	800	1	At	at	IN
cord-015021-pol2qm74	800	2	parallel	parallel	JJ
cord-015021-pol2qm74	800	3	time	time	NN
cord-015021-pol2qm74	800	4	points	point	NNS
cord-015021-pol2qm74	800	5	RES	res	NN
cord-015021-pol2qm74	800	6	clearance	clearance	NN
cord-015021-pol2qm74	800	7	capacity	capacity	NN
cord-015021-pol2qm74	800	8	(	(	-LRB-
cord-015021-pol2qm74	800	9	K	k	NN
cord-015021-pol2qm74	800	10	-	-	HYPH
cord-015021-pol2qm74	800	11	value	value	NN
cord-015021-pol2qm74	800	12	,	,	,
cord-015021-pol2qm74	800	13	invasion	invasion	NN
cord-015021-pol2qm74	800	14	constant	constant	JJ
cord-015021-pol2qm74	800	15	,	,	,
cord-015021-pol2qm74	800	16	normal	normal	JJ
cord-015021-pol2qm74	800	17	range	range	NN
cord-015021-pol2qm74	800	18	0.6	0.6	CD
cord-015021-pol2qm74	800	19	-0.8	-0.8	NN
cord-015021-pol2qm74	800	20	mind	mind	NN
cord-015021-pol2qm74	800	21	)	)	-RRB-
cord-015021-pol2qm74	800	22	was	be	VBD
cord-015021-pol2qm74	800	23	studied	study	VBN
cord-015021-pol2qm74	800	24	after	after	IN
cord-015021-pol2qm74	800	25	i.v	i.v	NNP
cord-015021-pol2qm74	800	26	.	.	NNP
cord-015021-pol2qm74	800	27	injection	injection	NN
cord-015021-pol2qm74	800	28	of	of	IN
cord-015021-pol2qm74	800	29	100	100	CD
cord-015021-pol2qm74	800	30	mBq	mBq	NNS
cord-015021-pol2qm74	800	31	99roTehuman	99rotehuman	CD
cord-015021-pol2qm74	800	32	albumin	albumin	NN
cord-015021-pol2qm74	800	33	.	.	.
cord-015021-pol2qm74	801	1	Liver	liver	NN
cord-015021-pol2qm74	801	2	perfusion	perfusion	NN
cord-015021-pol2qm74	801	3	was	be	VBD
cord-015021-pol2qm74	801	4	calculated	calculate	VBN
cord-015021-pol2qm74	801	5	from	from	IN
cord-015021-pol2qm74	801	6	these	these	DT
cord-015021-pol2qm74	801	7	data	datum	NNS
cord-015021-pol2qm74	801	8	,	,	,
cord-015021-pol2qm74	801	9	total	total	JJ
cord-015021-pol2qm74	801	10	serum	serum	NN
cord-015021-pol2qm74	801	11	bilirubin	bilirubin	NN
cord-015021-pol2qm74	801	12	(	(	-LRB-
cord-015021-pol2qm74	801	13	/zmol	/zmol	NNP
cord-015021-pol2qm74	801	14	/	/	SYM
cord-015021-pol2qm74	801	15	l	l	NN
cord-015021-pol2qm74	801	16	)	)	-RRB-
cord-015021-pol2qm74	801	17	was	be	VBD
cord-015021-pol2qm74	801	18	documented	document	VBN
cord-015021-pol2qm74	801	19	.	.	.
cord-015021-pol2qm74	802	1	Serum	serum	NN
cord-015021-pol2qm74	802	2	elastase	elastase	NN
cord-015021-pol2qm74	802	3	(	(	-LRB-
cord-015021-pol2qm74	802	4	#	#	$
cord-015021-pol2qm74	802	5	g	g	NN
cord-015021-pol2qm74	802	6	/	/	SYM
cord-015021-pol2qm74	802	7	l	l	NN
cord-015021-pol2qm74	802	8	)	)	-RRB-
cord-015021-pol2qm74	802	9	levels	level	NNS
cord-015021-pol2qm74	802	10	were	be	VBD
cord-015021-pol2qm74	802	11	determined	determine	VBN
cord-015021-pol2qm74	802	12	enzymatieally	enzymatieally	RB
cord-015021-pol2qm74	802	13	.	.	.
cord-015021-pol2qm74	803	1	RESULTS	result	NNS
cord-015021-pol2qm74	803	2	86.0	86.0	CD
cord-015021-pol2qm74	803	3	148	148	CD
cord-015021-pol2qm74	803	4	+	+	SYM
cord-015021-pol2qm74	803	5	239	239	CD
cord-015021-pol2qm74	804	1	+	+	CC
cord-015021-pol2qm74	804	2	Liver	liver	NN
cord-015021-pol2qm74	804	3	perfusion	perfusion	NN
cord-015021-pol2qm74	804	4	did	do	VBD
cord-015021-pol2qm74	804	5	not	not	RB
cord-015021-pol2qm74	804	6	ehangu	ehangu	NNP
cord-015021-pol2qm74	805	1	,	,	,
cord-015021-pol2qm74	805	2	bilirubin	bilirubin	NN
cord-015021-pol2qm74	805	3	showed	show	VBD
cord-015021-pol2qm74	805	4	progressive	progressive	JJ
cord-015021-pol2qm74	805	5	worsening	worsen	VBG
cord-015021-pol2qm74	805	6	indicating	indicate	VBG
cord-015021-pol2qm74	805	7	MOF	MOF	NNP
cord-015021-pol2qm74	805	8	.	.	.
cord-015021-pol2qm74	806	1	A	a	DT
cord-015021-pol2qm74	806	2	positive	positive	JJ
cord-015021-pol2qm74	806	3	correlation	correlation	NN
cord-015021-pol2qm74	806	4	was	be	VBD
cord-015021-pol2qm74	806	5	present	present	JJ
cord-015021-pol2qm74	806	6	between	between	IN
cord-015021-pol2qm74	806	7	L	L	NNP
cord-015021-pol2qm74	806	8	/	/	SYM
cord-015021-pol2qm74	806	9	m	m	NN
cord-015021-pol2qm74	806	10	and	and	CC
cord-015021-pol2qm74	806	11	K	K	NNP
cord-015021-pol2qm74	806	12	(	(	-LRB-
cord-015021-pol2qm74	806	13	r=0.88	r=0.88	NNP
cord-015021-pol2qm74	806	14	)	)	-RRB-
cord-015021-pol2qm74	806	15	and	and	CC
cord-015021-pol2qm74	806	16	between	between	IN
cord-015021-pol2qm74	806	17	L	L	NNP
cord-015021-pol2qm74	806	18	/	/	SYM
cord-015021-pol2qm74	806	19	m	m	NNP
cord-015021-pol2qm74	806	20	and	and	CC
cord-015021-pol2qm74	806	21	Ela	Ela	NNP
cord-015021-pol2qm74	806	22	(	(	-LRB-
cord-015021-pol2qm74	806	23	r=0.71	r=0.71	NNP
cord-015021-pol2qm74	806	24	)	)	-RRB-
cord-015021-pol2qm74	806	25	.	.	.
cord-015021-pol2qm74	807	1	CONCLUSIONS	conclusion	NNS
cord-015021-pol2qm74	807	2	:	:	:
cord-015021-pol2qm74	808	1	There	there	EX
cord-015021-pol2qm74	808	2	is	be	VBZ
cord-015021-pol2qm74	808	3	a	a	DT
cord-015021-pol2qm74	808	4	positive	positive	JJ
cord-015021-pol2qm74	808	5	correlation	correlation	NN
cord-015021-pol2qm74	808	6	between	between	IN
cord-015021-pol2qm74	808	7	the	the	DT
cord-015021-pol2qm74	808	8	time	time	NN
cord-015021-pol2qm74	808	9	pattern	pattern	NN
cord-015021-pol2qm74	808	10	of	of	IN
cord-015021-pol2qm74	808	11	intestinal	intestinal	JJ
cord-015021-pol2qm74	808	12	permeability	permeability	NN
cord-015021-pol2qm74	808	13	dysfunction	dysfunction	NN
cord-015021-pol2qm74	808	14	and	and	CC
cord-015021-pol2qm74	808	15	RES	res	NN
cord-015021-pol2qm74	808	16	hyperactivity	hyperactivity	NN
cord-015021-pol2qm74	808	17	as	as	RB
cord-015021-pol2qm74	808	18	well	well	RB
cord-015021-pol2qm74	808	19	as	as	IN
cord-015021-pol2qm74	808	20	between	between	IN
cord-015021-pol2qm74	808	21	intestinal	intestinal	JJ
cord-015021-pol2qm74	808	22	permeability	permeability	NN
cord-015021-pol2qm74	808	23	and	and	CC
cord-015021-pol2qm74	808	24	the	the	DT
cord-015021-pol2qm74	808	25	systemic	systemic	JJ
cord-015021-pol2qm74	808	26	intlammatory	intlammatory	JJ
cord-015021-pol2qm74	808	27	response	response	NN
cord-015021-pol2qm74	808	28	(	(	-LRB-
cord-015021-pol2qm74	808	29	elastase	elastase	NN
cord-015021-pol2qm74	808	30	levels	level	NNS
cord-015021-pol2qm74	808	31	)	)	-RRB-
cord-015021-pol2qm74	808	32	.	.	.
cord-015021-pol2qm74	809	1	The	the	DT
cord-015021-pol2qm74	809	2	results	result	NNS
cord-015021-pol2qm74	809	3	speak	speak	VBP
cord-015021-pol2qm74	809	4	in	in	IN
cord-015021-pol2qm74	809	5	favor	favor	NN
cord-015021-pol2qm74	809	6	of	of	IN
cord-015021-pol2qm74	809	7	an	an	DT
cord-015021-pol2qm74	809	8	interaction	interaction	NN
cord-015021-pol2qm74	809	9	between	between	IN
cord-015021-pol2qm74	809	10	intestinal	intestinal	JJ
cord-015021-pol2qm74	809	11	and	and	CC
cord-015021-pol2qm74	809	12	extraintestinal	extraintestinal	JJ
cord-015021-pol2qm74	809	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	809	14	systems	system	NNS
cord-015021-pol2qm74	809	15	,	,	,
cord-015021-pol2qm74	809	16	which	which	WDT
cord-015021-pol2qm74	809	17	in	in	IN
cord-015021-pol2qm74	809	18	eombiuation	eombiuation	NN
cord-015021-pol2qm74	809	19	are	be	VBP
cord-015021-pol2qm74	809	20	likely	likely	JJ
cord-015021-pol2qm74	809	21	to	to	TO
cord-015021-pol2qm74	809	22	be	be	VB
cord-015021-pol2qm74	809	23	responsible	responsible	JJ
cord-015021-pol2qm74	809	24	for	for	IN
cord-015021-pol2qm74	809	25	post	post	NNP
cord-015021-pol2qm74	809	26	~	~	CD
cord-015021-pol2qm74	809	27	anmafic	anmafic	JJ
cord-015021-pol2qm74	809	28	complications	complication	NNS
cord-015021-pol2qm74	809	29	.	.	.
cord-015021-pol2qm74	810	1	Endotoxemia	Endotoxemia	NNP
cord-015021-pol2qm74	810	2	,	,	,
cord-015021-pol2qm74	811	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	811	2	release	release	NN
cord-015021-pol2qm74	811	3	and	and	CC
cord-015021-pol2qm74	811	4	consecutive	consecutive	JJ
cord-015021-pol2qm74	811	5	acute	acute	JJ
cord-015021-pol2qm74	811	6	phase	phase	NN
cord-015021-pol2qm74	811	7	reaction	reaction	NN
cord-015021-pol2qm74	811	8	are	be	VBP
cord-015021-pol2qm74	811	9	observed	observe	VBN
cord-015021-pol2qm74	811	10	as	as	IN
cord-015021-pol2qm74	811	11	a	a	DT
cord-015021-pol2qm74	811	12	host	host	NN
cord-015021-pol2qm74	811	13	response	response	NN
cord-015021-pol2qm74	811	14	to	to	IN
cord-015021-pol2qm74	811	15	surgical	surgical	JJ
cord-015021-pol2qm74	811	16	trauma	trauma	NN
cord-015021-pol2qm74	811	17	.	.	.
cord-015021-pol2qm74	812	1	As	as	IN
cord-015021-pol2qm74	812	2	well	well	RB
cord-015021-pol2qm74	812	3	vasodilative	vasodilative	JJ
cord-015021-pol2qm74	812	4	prostaglandins	prostaglandin	NNS
cord-015021-pol2qm74	812	5	(	(	-LRB-
cord-015021-pol2qm74	812	6	PG	PG	NNP
cord-015021-pol2qm74	812	7	)	)	-RRB-
cord-015021-pol2qm74	812	8	and	and	CC
cord-015021-pol2qm74	812	9	thromboxane	thromboxane	NNP
cord-015021-pol2qm74	812	10	(	(	-LRB-
cord-015021-pol2qm74	812	11	TX	TX	NNP
cord-015021-pol2qm74	812	12	)	)	-RRB-
cord-015021-pol2qm74	812	13	are	be	VBP
cord-015021-pol2qm74	812	14	released	release	VBN
cord-015021-pol2qm74	812	15	after	after	IN
cord-015021-pol2qm74	812	16	abdominal	abdominal	JJ
cord-015021-pol2qm74	812	17	meaenteric	meaenteric	JJ
cord-015021-pol2qm74	812	18	traction	traction	NN
cord-015021-pol2qm74	812	19	(	(	-LRB-
cord-015021-pol2qm74	812	20	MT	MT	NNP
cord-015021-pol2qm74	812	21	)	)	-RRB-
cord-015021-pol2qm74	812	22	.	.	.
cord-015021-pol2qm74	813	1	The	the	DT
cord-015021-pol2qm74	813	2	following	follow	VBG
cord-015021-pol2qm74	813	3	hypotension	hypotension	NN
cord-015021-pol2qm74	813	4	and	and	CC
cord-015021-pol2qm74	813	5	acute	acute	JJ
cord-015021-pol2qm74	813	6	hypoxeraJa	hypoxeraJa	NNS
cord-015021-pol2qm74	813	7	are	be	VBP
cord-015021-pol2qm74	813	8	duo	duo	JJ
cord-015021-pol2qm74	813	9	to	to	IN
cord-015021-pol2qm74	813	10	prostacyelin	prostacyelin	NNP
cord-015021-pol2qm74	813	11	(	(	-LRB-
cord-015021-pol2qm74	813	12	PGIz	PGIz	NNP
cord-015021-pol2qm74	813	13	)	)	-RRB-
cord-015021-pol2qm74	813	14	arm	arm	NN
cord-015021-pol2qm74	813	15	can	can	MD
cord-015021-pol2qm74	813	16	be	be	VB
cord-015021-pol2qm74	813	17	avoided	avoid	VBN
cord-015021-pol2qm74	813	18	by	by	IN
cord-015021-pol2qm74	813	19	perioperative	perioperative	JJ
cord-015021-pol2qm74	813	20	cyclooxygenase	cyclooxygenase	JJ
cord-015021-pol2qm74	813	21	inhibition	inhibition	NN
cord-015021-pol2qm74	813	22	.	.	.
cord-015021-pol2qm74	814	1	We	-PRON-	PRP
cord-015021-pol2qm74	814	2	therefore	therefore	RB
cord-015021-pol2qm74	814	3	focused	focus	VBD
cord-015021-pol2qm74	814	4	on	on	IN
cord-015021-pol2qm74	814	5	the	the	DT
cord-015021-pol2qm74	814	6	effect	effect	NN
cord-015021-pol2qm74	814	7	of	of	IN
cord-015021-pol2qm74	814	8	PG	PG	NNP
cord-015021-pol2qm74	814	9	and	and	CC
cord-015021-pol2qm74	814	10	TX	TX	NNP
cord-015021-pol2qm74	814	11	liberated	liberate	VBD
cord-015021-pol2qm74	814	12	following	follow	VBG
cord-015021-pol2qm74	814	13	MT	MT	NNP
cord-015021-pol2qm74	814	14	on	on	IN
cord-015021-pol2qm74	814	15	the	the	DT
cord-015021-pol2qm74	814	16	induction	induction	NN
cord-015021-pol2qm74	814	17	of	of	IN
cord-015021-pol2qm74	814	18	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	814	19	.	.	.
cord-015021-pol2qm74	815	1	METHODS	methods	NN
cord-015021-pol2qm74	815	2	:	:	:
cord-015021-pol2qm74	816	1	In	in	IN
cord-015021-pol2qm74	816	2	a	a	DT
cord-015021-pol2qm74	816	3	prospective	prospective	NN
cord-015021-pol2qm74	816	4	,	,	,
cord-015021-pol2qm74	816	5	randomized	randomized	JJ
cord-015021-pol2qm74	816	6	double	double	JJ
cord-015021-pol2qm74	816	7	-	-	HYPH
cord-015021-pol2qm74	816	8	blinded	blinded	JJ
cord-015021-pol2qm74	816	9	protocol	protocol	NN
cord-015021-pol2qm74	816	10	50	50	CD
cord-015021-pol2qm74	816	11	patients	patient	NNS
cord-015021-pol2qm74	816	12	,	,	,
cord-015021-pol2qm74	816	13	who	who	WP
cord-015021-pol2qm74	816	14	were	be	VBD
cord-015021-pol2qm74	816	15	scheduled	schedule	VBN
cord-015021-pol2qm74	816	16	for	for	IN
cord-015021-pol2qm74	816	17	major	major	JJ
cord-015021-pol2qm74	816	18	abdominal	abdominal	JJ
cord-015021-pol2qm74	816	19	surgery	surgery	NN
cord-015021-pol2qm74	816	20	(	(	-LRB-
cord-015021-pol2qm74	816	21	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	816	22	or	or	CC
cord-015021-pol2qm74	816	23	infrarenal	infrarenal	JJ
cord-015021-pol2qm74	816	24	abdominal	abdominal	JJ
cord-015021-pol2qm74	816	25	surgery	surgery	NN
cord-015021-pol2qm74	816	26	)	)	-RRB-
cord-015021-pol2qm74	816	27	,	,	,
cord-015021-pol2qm74	816	28	were	be	VBD
cord-015021-pol2qm74	816	29	studied	study	VBN
cord-015021-pol2qm74	816	30	.	.	.
cord-015021-pol2qm74	817	1	Ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	817	2	(	(	-LRB-
cord-015021-pol2qm74	817	3	400	400	CD
cord-015021-pol2qm74	817	4	mg	mg	NNP
cord-015021-pol2qm74	817	5	i.v	i.v	NNP
cord-015021-pol2qm74	817	6	.	.	NNP
cord-015021-pol2qm74	817	7	)	)	-RRB-
cord-015021-pol2qm74	817	8	or	or	CC
cord-015021-pol2qm74	817	9	a	a	DT
cord-015021-pol2qm74	817	10	placebo	placebo	NN
cord-015021-pol2qm74	817	11	equivalent	equivalent	NN
cord-015021-pol2qm74	817	12	was	be	VBD
cord-015021-pol2qm74	817	13	administered	administer	VBN
cord-015021-pol2qm74	817	14	15	15	CD
cord-015021-pol2qm74	817	15	minutes	minute	NNS
cord-015021-pol2qm74	817	16	before	before	IN
cord-015021-pol2qm74	817	17	skin	skin	NN
cord-015021-pol2qm74	817	18	incision	incision	NN
cord-015021-pol2qm74	817	19	.	.	.
cord-015021-pol2qm74	818	1	MT	MT	NNP
cord-015021-pol2qm74	818	2	was	be	VBD
cord-015021-pol2qm74	818	3	applied	apply	VBN
cord-015021-pol2qm74	818	4	in	in	IN
cord-015021-pol2qm74	818	5	a	a	DT
cord-015021-pol2qm74	818	6	uniform	uniform	JJ
cord-015021-pol2qm74	818	7	fashion	fashion	NN
cord-015021-pol2qm74	818	8	.	.	.
cord-015021-pol2qm74	819	1	Baseline	baseline	JJ
cord-015021-pol2qm74	819	2	values	value	NNS
cord-015021-pol2qm74	819	3	were	be	VBD
cord-015021-pol2qm74	819	4	obtained	obtain	VBN
cord-015021-pol2qm74	819	5	before	before	IN
cord-015021-pol2qm74	819	6	induction	induction	NN
cord-015021-pol2qm74	819	7	of	of	IN
cord-015021-pol2qm74	819	8	anesthesia	anesthesia	NN
cord-015021-pol2qm74	819	9	.	.	.
cord-015021-pol2qm74	820	1	Further	further	JJ
cord-015021-pol2qm74	820	2	measurements	measurement	NNS
cord-015021-pol2qm74	820	3	followed	follow	VBN
cord-015021-pol2qm74	820	4	before	before	IN
cord-015021-pol2qm74	820	5	the	the	DT
cord-015021-pol2qm74	820	6	incision	incision	NN
cord-015021-pol2qm74	820	7	of	of	IN
cord-015021-pol2qm74	820	8	the	the	DT
cord-015021-pol2qm74	820	9	peri[onenm	peri[onenm	NNS
cord-015021-pol2qm74	820	10	(	(	-LRB-
cord-015021-pol2qm74	820	11	tl	tl	NNP
cord-015021-pol2qm74	820	12	)	)	-RRB-
cord-015021-pol2qm74	820	13	and	and	CC
cord-015021-pol2qm74	820	14	5	5	CD
cord-015021-pol2qm74	820	15	,	,	,
cord-015021-pol2qm74	820	16	30	30	CD
cord-015021-pol2qm74	820	17	,	,	,
cord-015021-pol2qm74	820	18	90	90	CD
cord-015021-pol2qm74	820	19	,	,	,
cord-015021-pol2qm74	820	20	180	180	CD
cord-015021-pol2qm74	820	21	min	min	NN
cord-015021-pol2qm74	820	22	,	,	,
cord-015021-pol2qm74	820	23	.	.	.
cord-015021-pol2qm74	821	1	The	the	DT
cord-015021-pol2qm74	821	2	plasma	plasma	NN
cord-015021-pol2qm74	821	3	concentrations	concentration	NNS
cord-015021-pol2qm74	821	4	(	(	-LRB-
cord-015021-pol2qm74	821	5	,	,	,
cord-015021-pol2qm74	821	6	pc	pc	NN
cord-015021-pol2qm74	821	7	)	)	-RRB-
cord-015021-pol2qm74	821	8	of	of	IN
cord-015021-pol2qm74	821	9	6-keto	6-keto	CD
cord-015021-pol2qm74	821	10	-	-	HYPH
cord-015021-pol2qm74	821	11	PGFt	PGFt	NNS
cord-015021-pol2qm74	821	12	,	,	,
cord-015021-pol2qm74	821	13	,	,	,
cord-015021-pol2qm74	821	14	TXB	TXB	NNP
cord-015021-pol2qm74	821	15	:	:	:
cord-015021-pol2qm74	821	16	and	and	CC
cord-015021-pol2qm74	821	17	-	-	HYPH
cord-015021-pol2qm74	821	18	KI-12-PGF	ki-12-pgf	NN
cord-015021-pol2qm74	821	19	~	~	NFP
cord-015021-pol2qm74	821	20	(	(	-LRB-
cord-015021-pol2qm74	821	21	stable	stable	JJ
cord-015021-pol2qm74	821	22	metabolites	metabolite	NNS
cord-015021-pol2qm74	821	23	of	of	IN
cord-015021-pol2qm74	821	24	PGI2	PGI2	NNP
cord-015021-pol2qm74	821	25	,	,	,
cord-015021-pol2qm74	821	26	TXA2	TXA2	NNP
cord-015021-pol2qm74	821	27	and	and	CC
cord-015021-pol2qm74	821	28	PGE~	PGE~	NNP
cord-015021-pol2qm74	821	29	)	)	-RRB-
cord-015021-pol2qm74	821	30	were	be	VBD
cord-015021-pol2qm74	821	31	determined	determine	VBN
cord-015021-pol2qm74	821	32	by	by	IN
cord-015021-pol2qm74	821	33	RIA	RIA	NNP
cord-015021-pol2qm74	821	34	.	.	.
cord-015021-pol2qm74	822	1	We	-PRON-	PRP
cord-015021-pol2qm74	822	2	measured	measure	VBD
cord-015021-pol2qm74	822	3	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	822	4	pc	pc	NN
cord-015021-pol2qm74	822	5	by	by	IN
cord-015021-pol2qm74	822	6	Limulus	Limulus	NNP
cord-015021-pol2qm74	822	7	-	-	HYPH
cord-015021-pol2qm74	822	8	amoebocyte	amoebocyte	NN
cord-015021-pol2qm74	822	9	-	-	HYPH
cord-015021-pol2qm74	822	10	lysate	lysate	NN
cord-015021-pol2qm74	822	11	test	test	NN
cord-015021-pol2qm74	822	12	and	and	CC
cord-015021-pol2qm74	822	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	822	14	levels	level	NNS
cord-015021-pol2qm74	822	15	by	by	IN
cord-015021-pol2qm74	822	16	ELISA	ELISA	NNP
cord-015021-pol2qm74	822	17	.	.	.
cord-015021-pol2qm74	823	1	Data	datum	NNS
cord-015021-pol2qm74	823	2	are	be	VBP
cord-015021-pol2qm74	823	3	given	give	VBN
cord-015021-pol2qm74	823	4	as	as	IN
cord-015021-pol2qm74	823	5	mean+SEM	mean+sem	NN
cord-015021-pol2qm74	823	6	(	(	-LRB-
cord-015021-pol2qm74	823	7	*	*	NFP
cord-015021-pol2qm74	823	8	p	p	XX
cord-015021-pol2qm74	823	9	<	<	XX
cord-015021-pol2qm74	823	10	0.05	0.05	CD
cord-015021-pol2qm74	823	11	placebo	placebo	NN
cord-015021-pol2qm74	823	12	vs.	vs.	IN
cord-015021-pol2qm74	823	13	[	[	-LRB-
cord-015021-pol2qm74	823	14	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	823	15	]	]	-RRB-
cord-015021-pol2qm74	823	16	)	)	-RRB-
cord-015021-pol2qm74	823	17	.	.	.
cord-015021-pol2qm74	824	1	RESULTS	result	NNS
cord-015021-pol2qm74	824	2	:	:	:
cord-015021-pol2qm74	825	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	825	2	plasma	plasma	NN
cord-015021-pol2qm74	825	3	levels	level	NNS
cord-015021-pol2qm74	825	4	increased	increase	VBD
cord-015021-pol2qm74	825	5	before	before	IN
cord-015021-pol2qm74	825	6	incision	incision	NN
cord-015021-pol2qm74	825	7	of	of	IN
cord-015021-pol2qm74	825	8	the	the	DT
cord-015021-pol2qm74	825	9	peritoneum	peritoneum	NN
cord-015021-pol2qm74	825	10	tl	tl	NN
cord-015021-pol2qm74	825	11	both	both	CC
cord-015021-pol2qm74	825	12	in	in	IN
cord-015021-pol2qm74	825	13	the	the	DT
cord-015021-pol2qm74	825	14	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	825	15	pretreated	pretreate	VBN
cord-015021-pol2qm74	825	16	and	and	CC
cord-015021-pol2qm74	825	17	in	in	IN
cord-015021-pol2qm74	825	18	the	the	DT
cord-015021-pol2qm74	825	19	placebo	placebo	NN
cord-015021-pol2qm74	825	20	group	group	NN
cord-015021-pol2qm74	825	21	.	.	.
cord-015021-pol2qm74	826	1	Peak	Peak	NNP
cord-015021-pol2qm74	826	2	pc	pc	NN
cord-015021-pol2qm74	826	3	were	be	VBD
cord-015021-pol2qm74	826	4	observed	observe	VBN
cord-015021-pol2qm74	826	5	180	180	CD
cord-015021-pol2qm74	826	6	minutes	minute	NNS
cord-015021-pol2qm74	826	7	after	after	IN
cord-015021-pol2qm74	826	8	MT	MT	NNP
cord-015021-pol2qm74	826	9	.	.	.
cord-015021-pol2qm74	827	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	827	2	pc	pc	NN
cord-015021-pol2qm74	827	3	were	be	VBD
cord-015021-pol2qm74	827	4	significantly	significantly	RB
cord-015021-pol2qm74	827	5	higher	high	JJR
cord-015021-pol2qm74	827	6	in	in	IN
cord-015021-pol2qm74	827	7	the	the	DT
cord-015021-pol2qm74	827	8	ibuprufen	ibuprufen	NN
cord-015021-pol2qm74	827	9	treated	treat	VBN
cord-015021-pol2qm74	827	10	group	group	NN
cord-015021-pol2qm74	827	11	(	(	-LRB-
cord-015021-pol2qm74	827	12	t5	t5	NNP
cord-015021-pol2qm74	827	13	0.16	0.16	CD
cord-015021-pol2qm74	827	14	+	+	SYM
cord-015021-pol2qm74	827	15	0.02e[0.32	0.02e[0.32	CD
cord-015021-pol2qm74	827	16	+	+	SYM
cord-015021-pol2qm74	827	17	0.06	0.06	CD
cord-015021-pol2qm74	827	18	]	]	-RRB-
cord-015021-pol2qm74	828	1	EU	EU	NNP
cord-015021-pol2qm74	828	2	/	/	SYM
cord-015021-pol2qm74	828	3	ml	ml	NN
cord-015021-pol2qm74	828	4	)	)	-RRB-
cord-015021-pol2qm74	828	5	.	.	.
cord-015021-pol2qm74	829	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	829	2	pc	pc	NNP
cord-015021-pol2qm74	829	3	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	829	4	an	an	DT
cord-015021-pol2qm74	829	5	increase	increase	NN
cord-015021-pol2qm74	829	6	continuously	continuously	RB
cord-015021-pol2qm74	829	7	from	from	IN
cord-015021-pol2qm74	829	8	t4	t4	NNP
cord-015021-pol2qm74	829	9	to	to	IN
cord-015021-pol2qm74	829	10	t7	t7	NNP
cord-015021-pol2qm74	829	11	(	(	-LRB-
cord-015021-pol2qm74	829	12	t7	t7	NNP
cord-015021-pol2qm74	829	13	115	115	CD
cord-015021-pol2qm74	829	14	+	+	SYM
cord-015021-pol2qm74	829	15	12	12	CD
cord-015021-pol2qm74	829	16	[	[	-LRB-
cord-015021-pol2qm74	829	17	91	91	CD
cord-015021-pol2qm74	829	18	+	+	SYM
cord-015021-pol2qm74	829	19	15	15	CD
cord-015021-pol2qm74	829	20	]	]	-RRB-
cord-015021-pol2qm74	830	1	ng	ng	NNP
cord-015021-pol2qm74	830	2	/	/	SYM
cord-015021-pol2qm74	830	3	l	l	NNP
cord-015021-pol2qm74	830	4	)	)	-RRB-
cord-015021-pol2qm74	830	5	in	in	IN
cord-015021-pol2qm74	830	6	both	both	DT
cord-015021-pol2qm74	830	7	groups	group	NNS
cord-015021-pol2qm74	830	8	.	.	.
cord-015021-pol2qm74	831	1	After	after	IN
cord-015021-pol2qm74	831	2	intentional	intentional	JJ
cord-015021-pol2qm74	831	3	abdominal	abdominal	JJ
cord-015021-pol2qm74	831	4	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	831	5	traction	traction	NN
cord-015021-pol2qm74	831	6	we	-PRON-	PRP
cord-015021-pol2qm74	831	7	observed	observe	VBD
cord-015021-pol2qm74	831	8	a	a	DT
cord-015021-pol2qm74	831	9	marked	marked	JJ
cord-015021-pol2qm74	831	10	increase	increase	NN
cord-015021-pol2qm74	831	11	of	of	IN
cord-015021-pol2qm74	831	12	6-keto	6-keto	CD
cord-015021-pol2qm74	831	13	-	-	HYPH
cord-015021-pol2qm74	831	14	PGF~	PGF~	NNP
cord-015021-pol2qm74	831	15	,	,	,
cord-015021-pol2qm74	831	16	,	,	,
cord-015021-pol2qm74	831	17	pc	pc	VB
cord-015021-pol2qm74	831	18	up	up	IN
cord-015021-pol2qm74	831	19	to	to	IN
cord-015021-pol2qm74	831	20	6h	6h	CD
cord-015021-pol2qm74	831	21	after	after	IN
cord-015021-pol2qm74	831	22	MT	MT	NNP
cord-015021-pol2qm74	831	23	in	in	IN
cord-015021-pol2qm74	831	24	untreated	untreated	JJ
cord-015021-pol2qm74	831	25	patients	patient	NNS
cord-015021-pol2qm74	831	26	with	with	IN
cord-015021-pol2qm74	831	27	a	a	DT
cord-015021-pol2qm74	831	28	peak	peak	NN
cord-015021-pol2qm74	831	29	of	of	IN
cord-015021-pol2qm74	831	30	2450*[60	2450*[60	CD
cord-015021-pol2qm74	831	31	]	]	-RRB-
cord-015021-pol2qm74	832	1	ng/1	ng/1	NNP
cord-015021-pol2qm74	832	2	at	at	IN
cord-015021-pol2qm74	832	3	tl	tl	NNP
cord-015021-pol2qm74	832	4	.	.	.
cord-015021-pol2qm74	833	1	Also	also	RB
cord-015021-pol2qm74	833	2	TXB	TXB	NNP
cord-015021-pol2qm74	833	3	:	:	:
cord-015021-pol2qm74	833	4	and	and	CC
cord-015021-pol2qm74	834	1	KH2PGE	KH2PGE	NNP
cord-015021-pol2qm74	834	2	2	2	CD
cord-015021-pol2qm74	834	3	pc	pc	NNP
cord-015021-pol2qm74	834	4	showed	show	VBD
cord-015021-pol2qm74	834	5	a	a	DT
cord-015021-pol2qm74	834	6	considerabe	considerabe	NN
cord-015021-pol2qm74	834	7	increase	increase	VB
cord-015021-pol2qm74	834	8	up	up	RB
cord-015021-pol2qm74	834	9	to	to	IN
cord-015021-pol2qm74	834	10	6h	6h	CD
cord-015021-pol2qm74	834	11	after	after	IN
cord-015021-pol2qm74	834	12	MT	MT	NNP
cord-015021-pol2qm74	834	13	in	in	IN
cord-015021-pol2qm74	834	14	the	the	DT
cord-015021-pol2qm74	834	15	placebo	placebo	NN
cord-015021-pol2qm74	834	16	group	group	NN
cord-015021-pol2qm74	834	17	.	.	.
cord-015021-pol2qm74	835	1	In	in	IN
cord-015021-pol2qm74	835	2	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	835	3	pretreated	pretreate	VBD
cord-015021-pol2qm74	835	4	patients	patient	NNS
cord-015021-pol2qm74	835	5	the	the	DT
cord-015021-pol2qm74	835	6	PG	PG	NNP
cord-015021-pol2qm74	835	7	and	and	CC
cord-015021-pol2qm74	835	8	TX	TX	NNP
cord-015021-pol2qm74	835	9	pc	pc	NNP
cord-015021-pol2qm74	835	10	remained	remain	VBD
cord-015021-pol2qm74	835	11	within	within	IN
cord-015021-pol2qm74	835	12	the	the	DT
cord-015021-pol2qm74	835	13	normal	normal	JJ
cord-015021-pol2qm74	835	14	range	range	NN
cord-015021-pol2qm74	835	15	.	.	.
cord-015021-pol2qm74	836	1	DISCUSSION	discussion	NN
cord-015021-pol2qm74	836	2	:	:	:
cord-015021-pol2qm74	837	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	837	2	data	datum	NNS
cord-015021-pol2qm74	837	3	clearly	clearly	RB
cord-015021-pol2qm74	837	4	indicate	indicate	VBP
cord-015021-pol2qm74	837	5	a	a	DT
cord-015021-pol2qm74	837	6	significant	significant	JJ
cord-015021-pol2qm74	837	7	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	837	8	and	and	CC
cord-015021-pol2qm74	837	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	837	10	release	release	NN
cord-015021-pol2qm74	837	11	following	follow	VBG
cord-015021-pol2qm74	837	12	major	major	JJ
cord-015021-pol2qm74	837	13	surgical	surgical	JJ
cord-015021-pol2qm74	837	14	trauma	trauma	NN
cord-015021-pol2qm74	837	15	which	which	WDT
cord-015021-pol2qm74	837	16	is	be	VBZ
cord-015021-pol2qm74	837	17	not	not	RB
cord-015021-pol2qm74	837	18	initiated	initiate	VBN
cord-015021-pol2qm74	837	19	either	either	CC
cord-015021-pol2qm74	837	20	by	by	IN
cord-015021-pol2qm74	837	21	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	837	22	or	or	CC
cord-015021-pol2qm74	837	23	thromboxane	thromboxane	NN
cord-015021-pol2qm74	837	24	release	release	NN
cord-015021-pol2qm74	837	25	.	.	.
cord-015021-pol2qm74	838	1	Moreover	moreover	RB
cord-015021-pol2qm74	838	2	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	838	3	is	be	VBZ
cord-015021-pol2qm74	838	4	accentuated	accentuate	VBN
cord-015021-pol2qm74	838	5	by	by	IN
cord-015021-pol2qm74	838	6	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	838	7	pretreatment	pretreatment	NN
cord-015021-pol2qm74	838	8	.	.	.
cord-015021-pol2qm74	839	1	Therefore	therefore	RB
cord-015021-pol2qm74	839	2	we	-PRON-	PRP
cord-015021-pol2qm74	839	3	hypothesize	hypothesize	VBP
cord-015021-pol2qm74	839	4	that	that	IN
cord-015021-pol2qm74	839	5	in	in	IN
cord-015021-pol2qm74	839	6	major	major	JJ
cord-015021-pol2qm74	839	7	abdominal	abdominal	JJ
cord-015021-pol2qm74	839	8	surgery	surgery	NN
cord-015021-pol2qm74	839	9	prostacyclin	prostacyclin	JJ
cord-015021-pol2qm74	839	10	release	release	NN
cord-015021-pol2qm74	839	11	-	-	:
cord-015021-pol2qm74	839	12	after	after	IN
cord-015021-pol2qm74	839	13	MT	MT	NNP
cord-015021-pol2qm74	839	14	may	may	MD
cord-015021-pol2qm74	839	15	play	play	VB
cord-015021-pol2qm74	839	16	a	a	DT
cord-015021-pol2qm74	839	17	crucial	crucial	JJ
cord-015021-pol2qm74	839	18	physiological	physiological	JJ
cord-015021-pol2qm74	839	19	role	role	NN
cord-015021-pol2qm74	839	20	in	in	IN
cord-015021-pol2qm74	839	21	maintaining	maintain	VBG
cord-015021-pol2qm74	839	22	splanclmic	splanclmic	NNP
cord-015021-pol2qm74	839	23	microcirculation	microcirculation	NNP
cord-015021-pol2qm74	839	24	and	and	CC
cord-015021-pol2qm74	839	25	thus	thus	RB
cord-015021-pol2qm74	839	26	preserving	preserve	VBG
cord-015021-pol2qm74	839	27	gut	gut	NN
cord-015021-pol2qm74	839	28	mucosal	mucosal	JJ
cord-015021-pol2qm74	839	29	barrier	barrier	NN
cord-015021-pol2qm74	839	30	function	function	NN
cord-015021-pol2qm74	839	31	.	.	.
cord-015021-pol2qm74	840	1	Objectives	objective	NNS
cord-015021-pol2qm74	840	2	of	of	IN
cord-015021-pol2qm74	840	3	the	the	DT
cord-015021-pol2qm74	840	4	study	study	NN
cord-015021-pol2qm74	840	5	It	-PRON-	PRP
cord-015021-pol2qm74	840	6	has	have	VBZ
cord-015021-pol2qm74	840	7	been	be	VBN
cord-015021-pol2qm74	840	8	shown	show	VBN
cord-015021-pol2qm74	840	9	recently	recently	RB
cord-015021-pol2qm74	840	10	that	that	IN
cord-015021-pol2qm74	840	11	parenteral	parenteral	JJ
cord-015021-pol2qm74	840	12	and	and	CC
cord-015021-pol2qm74	840	13	certain	certain	JJ
cord-015021-pol2qm74	840	14	euteral	euteral	JJ
cord-015021-pol2qm74	840	15	diets	diet	NNS
cord-015021-pol2qm74	840	16	promote	promote	VBP
cord-015021-pol2qm74	840	17	the	the	DT
cord-015021-pol2qm74	840	18	translocation	translocation	NN
cord-015021-pol2qm74	840	19	of	of	IN
cord-015021-pol2qm74	840	20	gut	gut	NN
cord-015021-pol2qm74	840	21	flora	flora	NNS
cord-015021-pol2qm74	840	22	to	to	IN
cord-015021-pol2qm74	840	23	the	the	DT
cord-015021-pol2qm74	840	24	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	840	25	lymph	lymph	NN
cord-015021-pol2qm74	840	26	nodes	node	NNS
cord-015021-pol2qm74	840	27	(	(	-LRB-
cord-015021-pol2qm74	840	28	MLN	mln	NN
cord-015021-pol2qm74	840	29	)	)	-RRB-
cord-015021-pol2qm74	840	30	and	and	CC
cord-015021-pol2qm74	840	31	systemic	systemic	JJ
cord-015021-pol2qm74	840	32	organs	organ	NNS
cord-015021-pol2qm74	840	33	,	,	,
cord-015021-pol2qm74	840	34	a	a	DT
cord-015021-pol2qm74	840	35	process	process	NN
cord-015021-pol2qm74	840	36	termed	term	VBN
cord-015021-pol2qm74	840	37	bacterial	bacterial	JJ
cord-015021-pol2qm74	840	38	translocation	translocation	NN
cord-015021-pol2qm74	840	39	(	(	-LRB-
cord-015021-pol2qm74	840	40	BT	BT	NNP
cord-015021-pol2qm74	840	41	)	)	-RRB-
cord-015021-pol2qm74	840	42	.	.	.
cord-015021-pol2qm74	841	1	In	in	IN
cord-015021-pol2qm74	841	2	chow	chow	NN
cord-015021-pol2qm74	841	3	fed	feed	VBD
cord-015021-pol2qm74	841	4	rats	rat	NNS
cord-015021-pol2qm74	841	5	BT	BT	NNP
cord-015021-pol2qm74	841	6	usually	usually	RB
cord-015021-pol2qm74	841	7	does	do	VBZ
cord-015021-pol2qm74	841	8	not	not	RB
cord-015021-pol2qm74	841	9	occur	occur	VB
cord-015021-pol2qm74	841	10	without	without	IN
cord-015021-pol2qm74	841	11	further	further	JJ
cord-015021-pol2qm74	841	12	promoting	promote	VBG
cord-015021-pol2qm74	841	13	factors	factor	NNS
cord-015021-pol2qm74	841	14	.	.	.
cord-015021-pol2qm74	842	1	The	the	DT
cord-015021-pol2qm74	842	2	goals	goal	NNS
cord-015021-pol2qm74	842	3	of	of	IN
cord-015021-pol2qm74	842	4	the	the	DT
cord-015021-pol2qm74	842	5	present	present	JJ
cord-015021-pol2qm74	842	6	study	study	NN
cord-015021-pol2qm74	842	7	were	be	VBD
cord-015021-pol2qm74	842	8	to	to	TO
cord-015021-pol2qm74	842	9	determine	determine	VB
cord-015021-pol2qm74	842	10	whether	whether	IN
cord-015021-pol2qm74	842	11	the	the	DT
cord-015021-pol2qm74	842	12	provision	provision	NN
cord-015021-pol2qm74	842	13	of	of	IN
cord-015021-pol2qm74	842	14	defined	define	VBN
cord-015021-pol2qm74	842	15	amounts	amount	NNS
cord-015021-pol2qm74	842	16	of	of	IN
cord-015021-pol2qm74	842	17	standard	standard	JJ
cord-015021-pol2qm74	842	18	lab	lab	NN
cord-015021-pol2qm74	842	19	chow	chow	NN
cord-015021-pol2qm74	842	20	during	during	IN
cord-015021-pol2qm74	842	21	IV	IV	NNP
cord-015021-pol2qm74	842	22	-	-	HYPH
cord-015021-pol2qm74	842	23	TPN	TPN	NNP
cord-015021-pol2qm74	842	24	administration	administration	NN
cord-015021-pol2qm74	842	25	wotfld	wotfld	NNP
cord-015021-pol2qm74	842	26	redane	redane	NNP
cord-015021-pol2qm74	842	27	the	the	DT
cord-015021-pol2qm74	842	28	incidence	incidence	NN
cord-015021-pol2qm74	842	29	of	of	IN
cord-015021-pol2qm74	842	30	BT	BT	NNP
cord-015021-pol2qm74	842	31	,	,	,
cord-015021-pol2qm74	842	32	Materials	material	NNS
cord-015021-pol2qm74	842	33	und	und	IN
cord-015021-pol2qm74	842	34	methods	method	NNS
cord-015021-pol2qm74	843	1	Male	male	JJ
cord-015021-pol2qm74	843	2	SPF	SPF	NNP
cord-015021-pol2qm74	843	3	Spragnle	Spragnle	NNP
cord-015021-pol2qm74	843	4	-	-	HYPH
cord-015021-pol2qm74	843	5	Dawley	Dawley	NNP
cord-015021-pol2qm74	843	6	rats	rat	NNS
cord-015021-pol2qm74	843	7	were	be	VBD
cord-015021-pol2qm74	843	8	divided	divide	VBN
cord-015021-pol2qm74	843	9	into	into	IN
cord-015021-pol2qm74	843	10	6	6	CD
cord-015021-pol2qm74	843	11	groups	group	NNS
cord-015021-pol2qm74	843	12	.	.	.
cord-015021-pol2qm74	844	1	Group	group	NN
cord-015021-pol2qm74	844	2	1	1	CD
cord-015021-pol2qm74	844	3	received	receive	VBD
cord-015021-pol2qm74	844	4	standard	standard	JJ
cord-015021-pol2qm74	844	5	laboratory	laboratory	NN
cord-015021-pol2qm74	844	6	chow	chow	NN
cord-015021-pol2qm74	844	7	feeding	feeding	NNP
cord-015021-pol2qm74	844	8	ad	ad	NN
cord-015021-pol2qm74	844	9	lib	lib	NN
cord-015021-pol2qm74	844	10	.	.	.
cord-015021-pol2qm74	845	1	In	in	IN
cord-015021-pol2qm74	845	2	group	group	NN
cord-015021-pol2qm74	845	3	2	2	CD
cord-015021-pol2qm74	845	4	a	a	DT
cord-015021-pol2qm74	845	5	central	central	JJ
cord-015021-pol2qm74	845	6	venous	venous	JJ
cord-015021-pol2qm74	845	7	catheter	catheter	NN
cord-015021-pol2qm74	845	8	was	be	VBD
cord-015021-pol2qm74	845	9	placed	place	VBN
cord-015021-pol2qm74	845	10	,	,	,
cord-015021-pol2qm74	845	11	ligated	ligate	VBN
cord-015021-pol2qm74	845	12	and	and	CC
cord-015021-pol2qm74	845	13	secured	secure	VBN
cord-015021-pol2qm74	845	14	by	by	IN
cord-015021-pol2qm74	845	15	a	a	DT
cord-015021-pol2qm74	845	16	spring	spring	NN
cord-015021-pol2qm74	845	17	coil	coil	NN
cord-015021-pol2qm74	845	18	tether	tether	NN
cord-015021-pol2qm74	845	19	attached	attach	VBN
cord-015021-pol2qm74	845	20	to	to	IN
cord-015021-pol2qm74	845	21	a	a	DT
cord-015021-pol2qm74	845	22	swivel	swivel	NN
cord-015021-pol2qm74	845	23	allowing	allow	VBG
cord-015021-pol2qm74	845	24	free	free	JJ
cord-015021-pol2qm74	845	25	movement	movement	NN
cord-015021-pol2qm74	845	26	in	in	IN
cord-015021-pol2qm74	845	27	the	the	DT
cord-015021-pol2qm74	845	28	housing	housing	NN
cord-015021-pol2qm74	845	29	cage	cage	NN
cord-015021-pol2qm74	845	30	and	and	CC
cord-015021-pol2qm74	845	31	chow	chow	NNP
cord-015021-pol2qm74	845	32	was	be	VBD
cord-015021-pol2qm74	845	33	fed	fed	NNP
cord-015021-pol2qm74	845	34	ad	ad	NN
cord-015021-pol2qm74	845	35	lib	lib	NN
cord-015021-pol2qm74	845	36	.	.	.
cord-015021-pol2qm74	846	1	In	in	IN
cord-015021-pol2qm74	846	2	group	group	NN
cord-015021-pol2qm74	846	3	3	3	CD
cord-015021-pol2qm74	846	4	50	50	CD
cord-015021-pol2qm74	846	5	%	%	NN
cord-015021-pol2qm74	846	6	of	of	IN
cord-015021-pol2qm74	846	7	the	the	DT
cord-015021-pol2qm74	846	8	calculated	calculate	VBN
cord-015021-pol2qm74	846	9	daily	daily	RB
cord-015021-pol2qm74	846	10	required	require	VBN
cord-015021-pol2qm74	846	11	calory	calory	NN
cord-015021-pol2qm74	846	12	intake	intake	NN
cord-015021-pol2qm74	846	13	(	(	-LRB-
cord-015021-pol2qm74	846	14	DRCI	DRCI	NNP
cord-015021-pol2qm74	846	15	)	)	-RRB-
cord-015021-pol2qm74	846	16	(	(	-LRB-
cord-015021-pol2qm74	846	17	307	307	CD
cord-015021-pol2qm74	846	18	/	/	SYM
cord-015021-pol2qm74	846	19	Kcal	Kcal	NNP
cord-015021-pol2qm74	846	20	/	/	SYM
cord-015021-pol2qm74	846	21	kg	kg	NNP
cord-015021-pol2qm74	846	22	)	)	-RRB-
cord-015021-pol2qm74	846	23	was	be	VBD
cord-015021-pol2qm74	846	24	given	give	VBN
cord-015021-pol2qm74	846	25	by	by	IN
cord-015021-pol2qm74	846	26	IV	IV	NNP
cord-015021-pol2qm74	846	27	-	-	HYPH
cord-015021-pol2qm74	846	28	TPN	TPN	NNP
cord-015021-pol2qm74	846	29	(	(	-LRB-
cord-015021-pol2qm74	846	30	28	28	CD
cord-015021-pol2qm74	846	31	%	%	NN
cord-015021-pol2qm74	846	32	glucose	glucose	NN
cord-015021-pol2qm74	846	33	,	,	,
cord-015021-pol2qm74	846	34	4,25	4,25	CD
cord-015021-pol2qm74	846	35	%	%	NN
cord-015021-pol2qm74	846	36	amino	amino	JJ
cord-015021-pol2qm74	846	37	acids	acid	NNS
cord-015021-pol2qm74	846	38	)	)	-RRB-
cord-015021-pol2qm74	846	39	and	and	CC
cord-015021-pol2qm74	846	40	50	50	CD
cord-015021-pol2qm74	846	41	%	%	NN
cord-015021-pol2qm74	846	42	by	by	IN
cord-015021-pol2qm74	846	43	limited	limited	NNP
cord-015021-pol2qm74	846	44	chow	chow	NNP
cord-015021-pol2qm74	846	45	administration	administration	NNP
cord-015021-pol2qm74	846	46	.	.	.
cord-015021-pol2qm74	847	1	Groups	group	NNS
cord-015021-pol2qm74	847	2	4	4	CD
cord-015021-pol2qm74	847	3	and	and	CC
cord-015021-pol2qm74	847	4	5	5	CD
cord-015021-pol2qm74	847	5	received	receive	VBD
cord-015021-pol2qm74	847	6	70	70	CD
cord-015021-pol2qm74	847	7	%	%	NN
cord-015021-pol2qm74	847	8	and	and	CC
cord-015021-pol2qm74	847	9	90	90	CD
cord-015021-pol2qm74	847	10	%	%	NN
cord-015021-pol2qm74	847	11	of	of	IN
cord-015021-pol2qm74	847	12	the	the	DT
cord-015021-pol2qm74	847	13	DRCI	DRCI	NNP
cord-015021-pol2qm74	847	14	by	by	IN
cord-015021-pol2qm74	847	15	i.v	i.v	NNP
cord-015021-pol2qm74	847	16	.	.	.
cord-015021-pol2qm74	847	17	TPN	TPN	NNP
cord-015021-pol2qm74	847	18	and	and	CC
cord-015021-pol2qm74	847	19	30	30	CD
cord-015021-pol2qm74	847	20	%	%	NN
cord-015021-pol2qm74	847	21	and	and	CC
cord-015021-pol2qm74	847	22	10	10	CD
cord-015021-pol2qm74	847	23	%	%	NN
cord-015021-pol2qm74	847	24	respectively	respectively	RB
cord-015021-pol2qm74	847	25	by	by	IN
cord-015021-pol2qm74	847	26	chow	chow	NN
cord-015021-pol2qm74	847	27	feeding	feeding	NN
cord-015021-pol2qm74	847	28	.	.	.
cord-015021-pol2qm74	848	1	Group	group	NN
cord-015021-pol2qm74	848	2	6	6	CD
cord-015021-pol2qm74	848	3	received	receive	VBD
cord-015021-pol2qm74	848	4	IV	IV	NNP
cord-015021-pol2qm74	848	5	-	-	HYPH
cord-015021-pol2qm74	848	6	TPN	TPN	NNP
cord-015021-pol2qm74	848	7	only	only	RB
cord-015021-pol2qm74	848	8	.	.	.
cord-015021-pol2qm74	849	1	After	after	IN
cord-015021-pol2qm74	849	2	7	7	CD
cord-015021-pol2qm74	849	3	days	day	NNS
cord-015021-pol2qm74	849	4	the	the	DT
cord-015021-pol2qm74	849	5	rats	rat	NNS
cord-015021-pol2qm74	849	6	were	be	VBD
cord-015021-pol2qm74	849	7	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	849	8	and	and	CC
cord-015021-pol2qm74	849	9	the	the	DT
cord-015021-pol2qm74	849	10	MLN	mln	NN
cord-015021-pol2qm74	849	11	,	,	,
cord-015021-pol2qm74	849	12	liver	liver	NN
cord-015021-pol2qm74	849	13	,	,	,
cord-015021-pol2qm74	849	14	spleen	spleen	NN
cord-015021-pol2qm74	849	15	and	and	CC
cord-015021-pol2qm74	849	16	cecum	cecum	NN
cord-015021-pol2qm74	849	17	removed	remove	VBN
cord-015021-pol2qm74	849	18	aseptically	aseptically	RB
cord-015021-pol2qm74	849	19	,	,	,
cord-015021-pol2qm74	849	20	homogenized	homogenize	VBN
cord-015021-pol2qm74	849	21	and	and	CC
cord-015021-pol2qm74	849	22	cultured	cultured	JJ
cord-015021-pol2qm74	849	23	for	for	IN
cord-015021-pol2qm74	849	24	BT	BT	NNP
cord-015021-pol2qm74	849	25	Samples	sample	NNS
cord-015021-pol2qm74	849	26	of	of	IN
cord-015021-pol2qm74	849	27	distal	distal	JJ
cord-015021-pol2qm74	849	28	ileum	ileum	NN
cord-015021-pol2qm74	849	29	were	be	VBD
cord-015021-pol2qm74	849	30	taken	take	VBN
cord-015021-pol2qm74	849	31	for	for	IN
cord-015021-pol2qm74	849	32	light	light	JJ
cord-015021-pol2qm74	849	33	microscopy	microscopy	NNS
cord-015021-pol2qm74	849	34	.	.	.
cord-015021-pol2qm74	850	1	The	the	DT
cord-015021-pol2qm74	850	2	group	group	NN
cord-015021-pol2qm74	850	3	with	with	IN
cord-015021-pol2qm74	850	4	the	the	DT
cord-015021-pol2qm74	850	5	least	least	JJS
cord-015021-pol2qm74	850	6	amount	amount	NN
cord-015021-pol2qm74	850	7	of	of	IN
cord-015021-pol2qm74	850	8	chow	chow	NN
cord-015021-pol2qm74	850	9	shown	show	VBN
cord-015021-pol2qm74	850	10	to	to	TO
cord-015021-pol2qm74	850	11	be	be	VB
cord-015021-pol2qm74	850	12	protective	protective	JJ
cord-015021-pol2qm74	850	13	against	against	IN
cord-015021-pol2qm74	850	14	BT	BT	NNP
cord-015021-pol2qm74	850	15	received	receive	VBD
cord-015021-pol2qm74	850	16	the	the	DT
cord-015021-pol2qm74	850	17	amount	amount	NN
cord-015021-pol2qm74	850	18	of	of	IN
cord-015021-pol2qm74	850	19	non	non	JJ
cord-015021-pol2qm74	850	20	-	-	JJ
cord-015021-pol2qm74	850	21	fermentable	fermentable	JJ
cord-015021-pol2qm74	850	22	fiber	fiber	NN
cord-015021-pol2qm74	850	23	of	of	IN
cord-015021-pol2qm74	850	24	that	that	DT
cord-015021-pol2qm74	850	25	chow	chow	NN
cord-015021-pol2qm74	850	26	regimen	regimen	NN
cord-015021-pol2qm74	850	27	during	during	IN
cord-015021-pol2qm74	850	28	IV	IV	NNP
cord-015021-pol2qm74	850	29	-	-	HYPH
cord-015021-pol2qm74	850	30	TPN	TPN	NNP
cord-015021-pol2qm74	850	31	feeding	feeding	NN
cord-015021-pol2qm74	850	32	and	and	CC
cord-015021-pol2qm74	850	33	BT	BT	NNP
cord-015021-pol2qm74	850	34	was	be	VBD
cord-015021-pol2qm74	850	35	studied	study	VBN
cord-015021-pol2qm74	850	36	.	.	.
cord-015021-pol2qm74	851	1	4	4	CD
cord-015021-pol2qm74	851	2	5,5	5,5	CD
cord-015021-pol2qm74	851	3	+	+	CD
cord-015021-pol2qm74	851	4	0,9	0,9	CD
cord-015021-pol2qm74	851	5	4	4	CD
cord-015021-pol2qm74	851	6	12	12	CD
cord-015021-pol2qm74	852	1	23,9	23,9	CD
cord-015021-pol2qm74	852	2	-2,3	-2,3	SYM
cord-015021-pol2qm74	852	3	16	16	CD
cord-015021-pol2qm74	852	4	,	,	,
cord-015021-pol2qm74	852	5	7	7	CD
cord-015021-pol2qm74	852	6	2/12	2/12	CD
cord-015021-pol2qm74	852	7	63	63	CD
cord-015021-pol2qm74	852	8	+	+	CD
cord-015021-pol2qm74	853	1	11	11	CD
cord-015021-pol2qm74	853	2	125~1	125~1	CD
cord-015021-pol2qm74	854	1	"	"	``
cord-015021-pol2qm74	854	2	7,7-+0,7	7,7-+0,7	NNP
cord-015021-pol2qm74	854	3	6,7-+1	6,7-+1	CD
cord-015021-pol2qm74	855	1	5	5	CD
cord-015021-pol2qm74	855	2	12	12	CD
cord-015021-pol2qm74	855	3	24~6	24~6	CD
cord-015021-pol2qm74	855	4	-3,5	-3,5	SYM
cord-015021-pol2qm74	855	5	67	67	CD
cord-015021-pol2qm74	855	6	8/12	8/12	CD
cord-015021-pol2qm74	856	1	241+~243	241+~243	CD
cord-015021-pol2qm74	856	2	170	170	CD
cord-015021-pol2qm74	856	3	+	+	SYM
cord-015021-pol2qm74	856	4	163	163	CD
cord-015021-pol2qm74	856	5	8_+0,7	8_+0,7	CD
cord-015021-pol2qm74	856	6	7	7	CD
cord-015021-pol2qm74	857	1	+1,1	+1,1	NNP
cord-015021-pol2qm74	857	2	6	6	CD
cord-015021-pol2qm74	857	3	18	18	CD
cord-015021-pol2qm74	857	4	25	25	CD
cord-015021-pol2qm74	857	5	,	,	,
cord-015021-pol2qm74	857	6	5	5	CD
cord-015021-pol2qm74	857	7	-4	-4	ADD
cord-015021-pol2qm74	858	1	88,8	88,8	CD
cord-015021-pol2qm74	858	2	16118	16118	CD
cord-015021-pol2qm74	859	1	2061-+3224	2061-+3224	CD
cord-015021-pol2qm74	859	2	2211	2211	CD
cord-015021-pol2qm74	859	3	+	+	CD
cord-015021-pol2qm74	859	4	4015	4015	CD
cord-015021-pol2qm74	859	5	8,4~0,7	8,4~0,7	CD
cord-015021-pol2qm74	859	6	8,1-+1~1	8,1-+1~1	CD
cord-015021-pol2qm74	860	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	860	2	:	:	:
cord-015021-pol2qm74	861	1	The	the	DT
cord-015021-pol2qm74	861	2	administration	administration	NN
cord-015021-pol2qm74	861	3	of	of	IN
cord-015021-pol2qm74	861	4	30	30	CD
cord-015021-pol2qm74	861	5	%	%	NN
cord-015021-pol2qm74	861	6	of	of	IN
cord-015021-pol2qm74	861	7	DRCI	DRCI	NNP
cord-015021-pol2qm74	861	8	by	by	IN
cord-015021-pol2qm74	861	9	chow	chow	NN
cord-015021-pol2qm74	861	10	feeding	feeding	NN
cord-015021-pol2qm74	861	11	during	during	IN
cord-015021-pol2qm74	861	12	IV	IV	NNP
cord-015021-pol2qm74	861	13	-	-	HYPH
cord-015021-pol2qm74	861	14	TPN	TPN	NNP
cord-015021-pol2qm74	861	15	significantly	significantly	RB
cord-015021-pol2qm74	861	16	reduced	reduce	VBD
cord-015021-pol2qm74	861	17	the	the	DT
cord-015021-pol2qm74	861	18	incidence	incidence	NN
cord-015021-pol2qm74	861	19	of	of	IN
cord-015021-pol2qm74	861	20	BT	BT	NNP
cord-015021-pol2qm74	861	21	and	and	CC
cord-015021-pol2qm74	861	22	maintained	maintain	VBD
cord-015021-pol2qm74	861	23	gut	gut	NN
cord-015021-pol2qm74	861	24	barrier	barrier	NN
cord-015021-pol2qm74	861	25	function	function	NN
cord-015021-pol2qm74	861	26	.	.	.
cord-015021-pol2qm74	862	1	The	the	DT
cord-015021-pol2qm74	862	2	addition	addition	NN
cord-015021-pol2qm74	862	3	of	of	IN
cord-015021-pol2qm74	862	4	the	the	DT
cord-015021-pol2qm74	862	5	respective	respective	JJ
cord-015021-pol2qm74	862	6	amount	amount	NN
cord-015021-pol2qm74	862	7	of	of	IN
cord-015021-pol2qm74	862	8	dietary	dietary	JJ
cord-015021-pol2qm74	862	9	fiber	fiber	NN
cord-015021-pol2qm74	862	10	of	of	IN
cord-015021-pol2qm74	862	11	this	this	DT
cord-015021-pol2qm74	862	12	group	group	NN
cord-015021-pol2qm74	862	13	did	do	VBD
cord-015021-pol2qm74	862	14	not	not	RB
cord-015021-pol2qm74	862	15	prevent	prevent	VB
cord-015021-pol2qm74	862	16	IV	IV	NNP
cord-015021-pol2qm74	862	17	-	-	HYPH
cord-015021-pol2qm74	862	18	TPN	TPN	NNP
cord-015021-pol2qm74	862	19	-	-	HYPH
cord-015021-pol2qm74	862	20	indueed	indueed	NN
cord-015021-pol2qm74	862	21	BT	BT	NNP
cord-015021-pol2qm74	862	22	.	.	.
cord-015021-pol2qm74	863	1	Dr.	Dr.	NNP
cord-015021-pol2qm74	863	2	med	med	NNP
cord-015021-pol2qm74	863	3	.	.	.
cord-015021-pol2qm74	863	4	M	M	NNP
cord-015021-pol2qm74	863	5	Naruhn	Naruhn	NNP
cord-015021-pol2qm74	863	6	.	.	.
cord-015021-pol2qm74	864	1	,	,	,
cord-015021-pol2qm74	864	2	Dep	Dep	NNP
cord-015021-pol2qm74	864	3	.	.	NNP
cord-015021-pol2qm74	864	4	of	of	IN
cord-015021-pol2qm74	864	5	General	General	NNP
cord-015021-pol2qm74	864	6	Surgery	Surgery	NNP
cord-015021-pol2qm74	864	7	,	,	,
cord-015021-pol2qm74	864	8	Eberhard	Eberhard	NNP
cord-015021-pol2qm74	864	9	-	-	HYPH
cord-015021-pol2qm74	864	10	Karls	Karls	NNP
cord-015021-pol2qm74	864	11	-	-	HYPH
cord-015021-pol2qm74	864	12	University	University	NNP
cord-015021-pol2qm74	864	13	,	,	,
cord-015021-pol2qm74	864	14	Hoppe	Hoppe	NNP
cord-015021-pol2qm74	864	15	-	-	HYPH
cord-015021-pol2qm74	864	16	Seyler	Seyler	NNP
cord-015021-pol2qm74	864	17	-	-	HYPH
cord-015021-pol2qm74	864	18	Str	Str	NNP
cord-015021-pol2qm74	864	19	.	.	.
cord-015021-pol2qm74	864	20	3	3	CD
cord-015021-pol2qm74	865	1	Previous	previous	JJ
cord-015021-pol2qm74	865	2	experimental	experimental	JJ
cord-015021-pol2qm74	865	3	studies	study	NNS
cord-015021-pol2qm74	865	4	have	have	VBP
cord-015021-pol2qm74	865	5	suggested	suggest	VBN
cord-015021-pol2qm74	865	6	that	that	IN
cord-015021-pol2qm74	865	7	a	a	DT
cord-015021-pol2qm74	865	8	disturbed	disturbed	JJ
cord-015021-pol2qm74	865	9	ecology	ecology	NN
cord-015021-pol2qm74	865	10	of	of	IN
cord-015021-pol2qm74	865	11	the	the	DT
cord-015021-pol2qm74	865	12	enteric	enteric	JJ
cord-015021-pol2qm74	865	13	bacterial	bacterial	JJ
cord-015021-pol2qm74	865	14	population	population	NN
cord-015021-pol2qm74	865	15	might	may	MD
cord-015021-pol2qm74	865	16	contribute	contribute	VB
cord-015021-pol2qm74	865	17	to	to	IN
cord-015021-pol2qm74	865	18	the	the	DT
cord-015021-pol2qm74	865	19	development	development	NN
cord-015021-pol2qm74	865	20	of	of	IN
cord-015021-pol2qm74	865	21	bacterial	bacterial	JJ
cord-015021-pol2qm74	865	22	translocation	translocation	NN
cord-015021-pol2qm74	865	23	from	from	IN
cord-015021-pol2qm74	865	24	the	the	DT
cord-015021-pol2qm74	865	25	gut	gut	NN
cord-015021-pol2qm74	865	26	in	in	IN
cord-015021-pol2qm74	865	27	acute	acute	JJ
cord-015021-pol2qm74	865	28	liver	liver	NN
cord-015021-pol2qm74	865	29	failure	failure	NN
cord-015021-pol2qm74	865	30	(	(	-LRB-
cord-015021-pol2qm74	865	31	ALF	ALF	NNP
cord-015021-pol2qm74	865	32	)	)	-RRB-
cord-015021-pol2qm74	865	33	.	.	.
cord-015021-pol2qm74	866	1	In	in	IN
cord-015021-pol2qm74	866	2	the	the	DT
cord-015021-pol2qm74	866	3	present	present	JJ
cord-015021-pol2qm74	866	4	study	study	NN
cord-015021-pol2qm74	866	5	,	,	,
cord-015021-pol2qm74	866	6	the	the	DT
cord-015021-pol2qm74	866	7	effect	effect	NN
cord-015021-pol2qm74	866	8	of	of	IN
cord-015021-pol2qm74	866	9	oral	oral	JJ
cord-015021-pol2qm74	866	10	administration	administration	NN
cord-015021-pol2qm74	866	11	of	of	IN
cord-015021-pol2qm74	866	12	Lactobacillus	Lactobacillus	NNP
cord-015021-pol2qm74	866	13	reuteri	reuteri	NN
cord-015021-pol2qm74	866	14	R2LC	r2lc	NN
cord-015021-pol2qm74	866	15	and	and	CC
cord-015021-pol2qm74	866	16	oat	oat	NN
cord-015021-pol2qm74	866	17	fiber	fiber	NN
cord-015021-pol2qm74	866	18	on	on	IN
cord-015021-pol2qm74	866	19	bacterial	bacterial	JJ
cord-015021-pol2qm74	866	20	overgrowth	overgrowth	NN
cord-015021-pol2qm74	866	21	and	and	CC
cord-015021-pol2qm74	866	22	translocation	translocation	NN
cord-015021-pol2qm74	866	23	was	be	VBD
cord-015021-pol2qm74	866	24	investigated	investigate	VBN
cord-015021-pol2qm74	866	25	in	in	IN
cord-015021-pol2qm74	866	26	rats	rat	NNS
cord-015021-pol2qm74	866	27	with	with	IN
cord-015021-pol2qm74	866	28	acute	acute	JJ
cord-015021-pol2qm74	866	29	liver	liver	NN
cord-015021-pol2qm74	866	30	failure	failure	NN
cord-015021-pol2qm74	866	31	induced	induce	VBN
cord-015021-pol2qm74	866	32	by	by	IN
cord-015021-pol2qm74	866	33	subtotal	subtotal	NN
cord-015021-pol2qm74	866	34	(	(	-LRB-
cord-015021-pol2qm74	866	35	90	90	CD
cord-015021-pol2qm74	866	36	%	%	NN
cord-015021-pol2qm74	866	37	)	)	-RRB-
cord-015021-pol2qm74	866	38	liver	liver	NN
cord-015021-pol2qm74	866	39	resection	resection	NN
cord-015021-pol2qm74	866	40	.	.	.
cord-015021-pol2qm74	867	1	The	the	DT
cord-015021-pol2qm74	867	2	oatmeal	oatmeal	NN
cord-015021-pol2qm74	867	3	soup	soup	NN
cord-015021-pol2qm74	867	4	base	base	NN
cord-015021-pol2qm74	867	5	was	be	VBD
cord-015021-pol2qm74	867	6	anaerobically	anaerobically	RB
cord-015021-pol2qm74	867	7	inoculated	inoculate	VBN
cord-015021-pol2qm74	867	8	with	with	IN
cord-015021-pol2qm74	867	9	lactobacillae	lactobacillae	NNS
cord-015021-pol2qm74	867	10	and	and	CC
cord-015021-pol2qm74	867	11	fermented	ferment	VBN
cord-015021-pol2qm74	867	12	for	for	IN
cord-015021-pol2qm74	867	13	15	15	CD
cord-015021-pol2qm74	867	14	hours	hour	NNS
cord-015021-pol2qm74	867	15	,	,	,
cord-015021-pol2qm74	867	16	after	after	IN
cord-015021-pol2qm74	867	17	which	which	WDT
cord-015021-pol2qm74	867	18	the	the	DT
cord-015021-pol2qm74	867	19	animals	animal	NNS
cord-015021-pol2qm74	867	20	were	be	VBD
cord-015021-pol2qm74	867	21	fed	feed	VBN
cord-015021-pol2qm74	867	22	with	with	IN
cord-015021-pol2qm74	867	23	either	either	CC
cord-015021-pol2qm74	867	24	fermented	fermented	JJ
cord-015021-pol2qm74	867	25	or	or	CC
cord-015021-pol2qm74	867	26	unfermented	unfermented	JJ
cord-015021-pol2qm74	867	27	oatmeal	oatmeal	NN
cord-015021-pol2qm74	867	28	or	or	CC
cord-015021-pol2qm74	867	29	saline	saline	NN
cord-015021-pol2qm74	867	30	daily	daily	RB
cord-015021-pol2qm74	867	31	for	for	IN
cord-015021-pol2qm74	867	32	6	6	CD
cord-015021-pol2qm74	867	33	days	day	NNS
cord-015021-pol2qm74	867	34	prior	prior	RB
cord-015021-pol2qm74	867	35	to	to	IN
cord-015021-pol2qm74	867	36	the	the	DT
cord-015021-pol2qm74	867	37	operation	operation	NN
cord-015021-pol2qm74	867	38	.	.	.
cord-015021-pol2qm74	868	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	868	2	translocation	translocation	NN
cord-015021-pol2qm74	868	3	to	to	IN
cord-015021-pol2qm74	868	4	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	868	5	lymph	lymph	NN
cord-015021-pol2qm74	868	6	nodes	node	NNS
cord-015021-pol2qm74	868	7	(	(	-LRB-
cord-015021-pol2qm74	868	8	MLN	mln	NN
cord-015021-pol2qm74	868	9	)	)	-RRB-
cord-015021-pol2qm74	868	10	and	and	CC
cord-015021-pol2qm74	868	11	the	the	DT
cord-015021-pol2qm74	868	12	systemic	systemic	JJ
cord-015021-pol2qm74	868	13	circulation	circulation	NN
cord-015021-pol2qm74	868	14	was	be	VBD
cord-015021-pol2qm74	868	15	determined	determine	VBN
cord-015021-pol2qm74	868	16	,	,	,
cord-015021-pol2qm74	868	17	as	as	RB
cord-015021-pol2qm74	868	18	well	well	RB
cord-015021-pol2qm74	868	19	as	as	IN
cord-015021-pol2qm74	868	20	the	the	DT
cord-015021-pol2qm74	868	21	intestinal	intestinal	JJ
cord-015021-pol2qm74	868	22	bacterial	bacterial	JJ
cord-015021-pol2qm74	868	23	flora	flora	NNS
cord-015021-pol2qm74	868	24	and	and	CC
cord-015021-pol2qm74	868	25	enterocyte	enterocyte	NNP
cord-015021-pol2qm74	868	26	protein	protein	NN
cord-015021-pol2qm74	868	27	content	content	NN
cord-015021-pol2qm74	868	28	.	.	.
cord-015021-pol2qm74	869	1	The	the	DT
cord-015021-pol2qm74	869	2	incidence	incidence	NN
cord-015021-pol2qm74	869	3	of	of	IN
cord-015021-pol2qm74	869	4	bacterial	bacterial	JJ
cord-015021-pol2qm74	869	5	translocstion	translocstion	NN
cord-015021-pol2qm74	869	6	to	to	IN
cord-015021-pol2qm74	869	7	the	the	DT
cord-015021-pol2qm74	869	8	systemic	systemic	JJ
cord-015021-pol2qm74	869	9	circulation	circulation	NN
cord-015021-pol2qm74	869	10	was	be	VBD
cord-015021-pol2qm74	869	11	nit	nit	NN
cord-015021-pol2qm74	869	12	in	in	IN
cord-015021-pol2qm74	869	13	rats	rat	NNS
cord-015021-pol2qm74	869	14	subjected	subject	VBN
cord-015021-pol2qm74	869	15	to	to	IN
cord-015021-pol2qm74	869	16	sham	sham	JJ
cord-015021-pol2qm74	869	17	operation	operation	NN
cord-015021-pol2qm74	869	18	and	and	CC
cord-015021-pol2qm74	869	19	saline	saline	NN
cord-015021-pol2qm74	869	20	treatment	treatment	NN
cord-015021-pol2qm74	869	21	and	and	CC
cord-015021-pol2qm74	869	22	17	17	CD
cord-015021-pol2qm74	869	23	%	%	NN
cord-015021-pol2qm74	869	24	in	in	IN
cord-015021-pol2qm74	869	25	animals	animal	NNS
cord-015021-pol2qm74	869	26	subjected	subject	VBN
cord-015021-pol2qm74	869	27	to	to	IN
cord-015021-pol2qm74	869	28	90	90	CD
cord-015021-pol2qm74	869	29	%	%	NN
cord-015021-pol2qm74	869	30	bepatectomy	bepatectomy	NN
cord-015021-pol2qm74	869	31	and	and	CC
cord-015021-pol2qm74	869	32	lreatment	lreatment	NN
cord-015021-pol2qm74	869	33	with	with	IN
cord-015021-pol2qm74	869	34	fermented	ferment	VBN
cord-015021-pol2qm74	869	35	oatmeal	oatmeal	NN
cord-015021-pol2qm74	869	36	,	,	,
cord-015021-pol2qm74	869	37	while	while	IN
cord-015021-pol2qm74	869	38	80	80	CD
cord-015021-pol2qm74	869	39	-	-	SYM
cord-015021-pol2qm74	869	40	90	90	CD
cord-015021-pol2qm74	869	41	%	%	NN
cord-015021-pol2qm74	869	42	and	and	CC
cord-015021-pol2qm74	869	43	34	34	CD
cord-015021-pol2qm74	869	44	-	-	SYM
cord-015021-pol2qm74	869	45	50	50	CD
cord-015021-pol2qm74	869	46	%	%	NN
cord-015021-pol2qm74	869	47	,	,	,
cord-015021-pol2qm74	869	48	respectively	respectively	RB
cord-015021-pol2qm74	869	49	,	,	,
cord-015021-pol2qm74	869	50	in	in	IN
cord-015021-pol2qm74	869	51	rats	rat	NNS
cord-015021-pol2qm74	869	52	subjected	subject	VBN
cord-015021-pol2qm74	869	53	to	to	IN
cord-015021-pol2qm74	869	54	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	869	55	and	and	CC
cord-015021-pol2qm74	869	56	treatment	treatment	NN
cord-015021-pol2qm74	869	57	with	with	IN
cord-015021-pol2qm74	869	58	either	either	CC
cord-015021-pol2qm74	869	59	saline	saline	NN
cord-015021-pol2qm74	869	60	or	or	CC
cord-015021-pol2qm74	869	61	unfermented	unfermented	JJ
cord-015021-pol2qm74	869	62	oatmeal	oatmeal	NN
cord-015021-pol2qm74	869	63	.	.	.
cord-015021-pol2qm74	870	1	Only	only	RB
cord-015021-pol2qm74	870	2	one	one	CD
cord-015021-pol2qm74	870	3	rat	rat	NN
cord-015021-pol2qm74	870	4	with	with	IN
cord-015021-pol2qm74	870	5	fermented	ferment	VBN
cord-015021-pol2qm74	870	6	oatmeal	oatmeal	NN
cord-015021-pol2qm74	870	7	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	870	8	bacterial	bacterial	JJ
cord-015021-pol2qm74	870	9	growth	growth	NN
cord-015021-pol2qm74	870	10	in	in	IN
cord-015021-pol2qm74	870	11	MLN	mln	NN
cord-015021-pol2qm74	870	12	(	(	-LRB-
cord-015021-pol2qm74	870	13	p	p	NN
cord-015021-pol2qm74	870	14	<	<	XX
cord-015021-pol2qm74	870	15	0.05	0.05	CD
cord-015021-pol2qm74	870	16	vs	vs	IN
cord-015021-pol2qm74	870	17	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	870	18	and	and	CC
cord-015021-pol2qm74	870	19	treatment	treatment	NN
cord-015021-pol2qm74	870	20	with	with	IN
cord-015021-pol2qm74	870	21	saline	saline	NN
cord-015021-pol2qm74	870	22	or	or	CC
cord-015021-pol2qm74	870	23	unfermented	unfermented	JJ
cord-015021-pol2qm74	870	24	oatmeal	oatmeal	NN
cord-015021-pol2qm74	870	25	)	)	-RRB-
cord-015021-pol2qm74	870	26	.	.	.
cord-015021-pol2qm74	871	1	The	the	DT
cord-015021-pol2qm74	871	2	enterocyte	enterocyte	NNP
cord-015021-pol2qm74	871	3	protein	protein	NN
cord-015021-pol2qm74	871	4	content	content	NN
cord-015021-pol2qm74	871	5	significantly	significantly	RB
cord-015021-pol2qm74	871	6	decreased	decrease	VBD
cord-015021-pol2qm74	871	7	(	(	-LRB-
cord-015021-pol2qm74	871	8	p	p	NN
cord-015021-pol2qm74	871	9	<	<	XX
cord-015021-pol2qm74	871	10	0.01	0.01	CD
cord-015021-pol2qm74	871	11	)	)	-RRB-
cord-015021-pol2qm74	871	12	in	in	IN
cord-015021-pol2qm74	871	13	salinetreated	salinetreate	VBN
cord-015021-pol2qm74	871	14	animals	animal	NNS
cord-015021-pol2qm74	871	15	following	follow	VBG
cord-015021-pol2qm74	871	16	90	90	CD
cord-015021-pol2qm74	871	17	%	%	NN
cord-015021-pol2qm74	871	18	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	871	19	,	,	,
cord-015021-pol2qm74	871	20	while	while	IN
cord-015021-pol2qm74	871	21	there	there	EX
cord-015021-pol2qm74	871	22	was	be	VBD
cord-015021-pol2qm74	871	23	no	no	DT
cord-015021-pol2qm74	871	24	significant	significant	JJ
cord-015021-pol2qm74	871	25	difference	difference	NN
cord-015021-pol2qm74	871	26	between	between	IN
cord-015021-pol2qm74	871	27	bepatectomized	bepatectomized	JJ
cord-015021-pol2qm74	871	28	animals	animal	NNS
cord-015021-pol2qm74	871	29	with	with	IN
cord-015021-pol2qm74	871	30	oral	oral	JJ
cord-015021-pol2qm74	871	31	administration	administration	NN
cord-015021-pol2qm74	871	32	of	of	IN
cord-015021-pol2qm74	871	33	fermented	ferment	VBN
cord-015021-pol2qm74	871	34	or	or	CC
cord-015021-pol2qm74	871	35	unfermented	unfermented	JJ
cord-015021-pol2qm74	871	36	oatmeal	oatmeal	NN
cord-015021-pol2qm74	871	37	.	.	.
cord-015021-pol2qm74	872	1	The	the	DT
cord-015021-pol2qm74	872	2	number	number	NN
cord-015021-pol2qm74	872	3	of	of	IN
cord-015021-pol2qm74	872	4	anaerobic	anaerobic	JJ
cord-015021-pol2qm74	872	5	bacteria	bacteria	NNS
cord-015021-pol2qm74	872	6	,	,	,
cord-015021-pol2qm74	872	7	Gram	gram	NN
cord-015021-pol2qm74	872	8	-	-	HYPH
cord-015021-pol2qm74	872	9	negative	negative	JJ
cord-015021-pol2qm74	872	10	anaerobes	anaerobe	NNS
cord-015021-pol2qm74	872	11	and	and	CC
cord-015021-pol2qm74	872	12	Lactobacillus	lactobacillus	NN
cord-015021-pol2qm74	872	13	significantly	significantly	RB
cord-015021-pol2qm74	872	14	decreased	decrease	VBD
cord-015021-pol2qm74	872	15	and	and	CC
cord-015021-pol2qm74	872	16	the	the	DT
cord-015021-pol2qm74	872	17	number	number	NN
cord-015021-pol2qm74	872	18	of	of	IN
cord-015021-pol2qm74	872	19	E.cnli	E.cnli	NNS
cord-015021-pol2qm74	872	20	increased	increase	VBD
cord-015021-pol2qm74	872	21	in	in	IN
cord-015021-pol2qm74	872	22	the	the	DT
cord-015021-pol2qm74	872	23	distal	distal	JJ
cord-015021-pol2qm74	872	24	small	small	JJ
cord-015021-pol2qm74	872	25	intestine	intestine	NN
cord-015021-pol2qm74	872	26	and	and	CC
cord-015021-pol2qm74	872	27	colon	colon	NN
cord-015021-pol2qm74	872	28	in	in	IN
cord-015021-pol2qm74	872	29	hepatectomized	hepatectomized	JJ
cord-015021-pol2qm74	872	30	animals	animal	NNS
cord-015021-pol2qm74	872	31	with	with	IN
cord-015021-pol2qm74	872	32	enteral	enteral	JJ
cord-015021-pol2qm74	872	33	saline	saline	NN
cord-015021-pol2qm74	872	34	or	or	CC
cord-015021-pol2qm74	872	35	unfermented	unfermented	JJ
cord-015021-pol2qm74	872	36	oatmeal	oatmeal	NN
cord-015021-pol2qm74	872	37	as	as	IN
cord-015021-pol2qm74	872	38	compared	compare	VBN
cord-015021-pol2qm74	872	39	with	with	IN
cord-015021-pol2qm74	872	40	animals	animal	NNS
cord-015021-pol2qm74	872	41	subjected	subject	VBN
cord-015021-pol2qm74	872	42	to	to	IN
cord-015021-pol2qm74	872	43	sham	sham	JJ
cord-015021-pol2qm74	872	44	operation	operation	NN
cord-015021-pol2qm74	872	45	or	or	CC
cord-015021-pol2qm74	872	46	bepatectomy	bepatectomy	NN
cord-015021-pol2qm74	872	47	with	with	IN
cord-015021-pol2qm74	872	48	fermented	ferment	VBN
cord-015021-pol2qm74	872	49	oatmeal	oatmeal	NN
cord-015021-pol2qm74	872	50	.	.	.
cord-015021-pol2qm74	873	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	873	2	results	result	NNS
cord-015021-pol2qm74	873	3	thus	thus	RB
cord-015021-pol2qm74	873	4	show	show	VBP
cord-015021-pol2qm74	873	5	that	that	IN
cord-015021-pol2qm74	873	6	the	the	DT
cord-015021-pol2qm74	873	7	occurrence	occurrence	NN
cord-015021-pol2qm74	873	8	of	of	IN
cord-015021-pol2qm74	873	9	bacterial	bacterial	JJ
cord-015021-pol2qm74	873	10	translocatiou	translocatiou	NN
cord-015021-pol2qm74	873	11	from	from	IN
cord-015021-pol2qm74	873	12	the	the	DT
cord-015021-pol2qm74	873	13	gut	gut	NN
cord-015021-pol2qm74	873	14	in	in	IN
cord-015021-pol2qm74	873	15	90	90	CD
cord-015021-pol2qm74	873	16	%	%	NN
cord-015021-pol2qm74	873	17	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	873	18	-	-	HYPH
cord-015021-pol2qm74	873	19	induced	induce	VBN
cord-015021-pol2qm74	873	20	ALF	ALF	NNP
cord-015021-pol2qm74	873	21	could	could	MD
cord-015021-pol2qm74	873	22	be	be	VB
cord-015021-pol2qm74	873	23	prevented	prevent	VBN
cord-015021-pol2qm74	873	24	by	by	IN
cord-015021-pol2qm74	873	25	enteral	enteral	NNP
cord-015021-pol2qm74	873	26	administration	administration	NN
cord-015021-pol2qm74	873	27	of	of	IN
cord-015021-pol2qm74	873	28	fermented	ferment	VBN
cord-015021-pol2qm74	873	29	oatmeal	oatmeal	NN
cord-015021-pol2qm74	873	30	,	,	,
cord-015021-pol2qm74	873	31	maybe	maybe	RB
cord-015021-pol2qm74	873	32	partly	partly	RB
cord-015021-pol2qm74	873	33	due	due	JJ
cord-015021-pol2qm74	873	34	to	to	IN
cord-015021-pol2qm74	873	35	a	a	DT
cord-015021-pol2qm74	873	36	positive	positive	JJ
cord-015021-pol2qm74	873	37	effect	effect	NN
cord-015021-pol2qm74	873	38	on	on	IN
cord-015021-pol2qm74	873	39	the	the	DT
cord-015021-pol2qm74	873	40	enteric	enteric	JJ
cord-015021-pol2qm74	873	41	bacterial	bacterial	JJ
cord-015021-pol2qm74	873	42	ecology	ecology	NN
cord-015021-pol2qm74	873	43	.	.	.
cord-015021-pol2qm74	874	1	190_+20	190_+20	CD
cord-015021-pol2qm74	875	1	"	"	``
cord-015021-pol2qm74	875	2	16+_3	16+_3	CD
cord-015021-pol2qm74	876	1	"	"	``
cord-015021-pol2qm74	876	2	11.7	11.7	CD
cord-015021-pol2qm74	876	3	"	"	''
cord-015021-pol2qm74	876	4	Data=	Data=	NNS
cord-015021-pol2qm74	877	1	Mean_+SD	mean_+sd	RB
cord-015021-pol2qm74	877	2	,	,	,
cord-015021-pol2qm74	877	3	*	*	NFP
cord-015021-pol2qm74	877	4	stats	stat	VBZ
cord-015021-pol2qm74	877	5	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	877	6	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	877	7	vs	vs	IN
cord-015021-pol2qm74	877	8	control	control	NN
cord-015021-pol2qm74	877	9	.	.	.
cord-015021-pol2qm74	878	1	L+air	l+air	NN
cord-015021-pol2qm74	878	2	and	and	CC
cord-015021-pol2qm74	878	3	lap	lap	NN
cord-015021-pol2qm74	878	4	groups	group	NNS
cord-015021-pol2qm74	878	5	,	,	,
cord-015021-pol2qm74	878	6	both	both	DT
cord-015021-pol2qm74	878	7	exposed	expose	VBN
cord-015021-pol2qm74	878	8	to	to	IN
cord-015021-pol2qm74	878	9	exogenous	exogenous	JJ
cord-015021-pol2qm74	878	10	I.PS	i.ps	NN
cord-015021-pol2qm74	878	11	shnwm	shnwm	NN
cord-015021-pol2qm74	878	12	:	:	:
cord-015021-pol2qm74	878	13	t	t	NNP
cord-015021-pol2qm74	878	14	m	m	NNP
cord-015021-pol2qm74	878	15	significant	significant	JJ
cord-015021-pol2qm74	878	16	increase	increase	NN
cord-015021-pol2qm74	878	17	(	(	-LRB-
cord-015021-pol2qm74	878	18	p<.05	p<.05	NNP
cord-015021-pol2qm74	878	19	)	)	-RRB-
cord-015021-pol2qm74	878	20	in	in	IN
cord-015021-pol2qm74	878	21	LPS	LPS	NNP
cord-015021-pol2qm74	878	22	gut	gut	NN
cord-015021-pol2qm74	878	23	translocation	translocation	NN
cord-015021-pol2qm74	878	24	compared	compare	VBN
cord-015021-pol2qm74	878	25	to	to	IN
cord-015021-pol2qm74	878	26	control	control	NN
cord-015021-pol2qm74	878	27	and	and	CC
cord-015021-pol2qm74	878	28	L+CO2	L+CO2	NNP
cord-015021-pol2qm74	878	29	.	.	.
cord-015021-pol2qm74	879	1	This	this	DT
cord-015021-pol2qm74	879	2	correlated	correlate	VBD
cord-015021-pol2qm74	879	3	with	with	IN
cord-015021-pol2qm74	879	4	a	a	DT
cord-015021-pol2qm74	879	5	significant	significant	JJ
cord-015021-pol2qm74	879	6	increase	increase	NN
cord-015021-pol2qm74	879	7	in	in	IN
cord-015021-pol2qm74	879	8	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	879	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	879	10	responses	response	NNS
cord-015021-pol2qm74	879	11	(	(	-LRB-
cord-015021-pol2qm74	879	12	O2-,TNF	o2-,tnf	NN
cord-015021-pol2qm74	879	13	)	)	-RRB-
cord-015021-pol2qm74	879	14	above	above	IN
cord-015021-pol2qm74	879	15	that	that	DT
cord-015021-pol2qm74	879	16	of	of	IN
cord-015021-pol2qm74	879	17	the	the	DT
cord-015021-pol2qm74	879	18	control	control	NN
cord-015021-pol2qm74	879	19	and	and	CC
cord-015021-pol2qm74	879	20	L+CO2	L+CO2	NNP
cord-015021-pol2qm74	879	21	groups	group	NNS
cord-015021-pol2qm74	879	22	,	,	,
cord-015021-pol2qm74	879	23	while	while	IN
cord-015021-pol2qm74	879	24	Mac-1	Mac-1	NNP
cord-015021-pol2qm74	879	25	and	and	CC
cord-015021-pol2qm74	879	26	CR3	CR3	NNP
cord-015021-pol2qm74	879	27	opsonized	opsonize	VBN
cord-015021-pol2qm74	879	28	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	879	29	were	be	VBD
cord-015021-pol2qm74	879	30	significantly	significantly	RB
cord-015021-pol2qm74	879	31	impaired	impair	VBN
cord-015021-pol2qm74	879	32	.	.	.
cord-015021-pol2qm74	880	1	The	the	DT
cord-015021-pol2qm74	880	2	absence	absence	NN
cord-015021-pol2qm74	880	3	of	of	IN
cord-015021-pol2qm74	880	4	significant	significant	JJ
cord-015021-pol2qm74	880	5	differences	difference	NNS
cord-015021-pol2qm74	880	6	between	between	IN
cord-015021-pol2qm74	880	7	L+air	l+air	NN
cord-015021-pol2qm74	880	8	and	and	CC
cord-015021-pol2qm74	880	9	lap	lap	NN
cord-015021-pol2qm74	880	10	groups	group	NNS
cord-015021-pol2qm74	880	11	indicates	indicate	VBZ
cord-015021-pol2qm74	880	12	that	that	IN
cord-015021-pol2qm74	880	13	LPS	LPS	NNP
cord-015021-pol2qm74	880	14	rather	rather	RB
cord-015021-pol2qm74	880	15	than	than	IN
cord-015021-pol2qm74	880	16	wound	wound	NN
cord-015021-pol2qm74	880	17	factors	factor	NNS
cord-015021-pol2qm74	880	18	is	be	VBZ
cord-015021-pol2qm74	880	19	the	the	DT
cord-015021-pol2qm74	880	20	principle	principle	JJ
cord-015021-pol2qm74	880	21	mediator	mediator	NN
cord-015021-pol2qm74	880	22	.	.	.
cord-015021-pol2qm74	881	1	Thus	thus	RB
cord-015021-pol2qm74	881	2	,	,	,
cord-015021-pol2qm74	881	3	LPS	LPS	NNP
cord-015021-pol2qm74	881	4	plays	play	VBZ
cord-015021-pol2qm74	881	5	a	a	DT
cord-015021-pol2qm74	881	6	significant	significant	JJ
cord-015021-pol2qm74	881	7	role	role	NN
cord-015021-pol2qm74	881	8	in	in	IN
cord-015021-pol2qm74	881	9	regulating	regulate	VBG
cord-015021-pol2qm74	881	10	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	881	11	responses	response	NNS
cord-015021-pol2qm74	881	12	in	in	IN
cord-015021-pol2qm74	881	13	the	the	DT
cord-015021-pol2qm74	881	14	early	early	JJ
cord-015021-pol2qm74	881	15	post	post	JJ
cord-015021-pol2qm74	881	16	-	-	JJ
cord-015021-pol2qm74	881	17	operative	operative	JJ
cord-015021-pol2qm74	881	18	period	period	NN
cord-015021-pol2qm74	881	19	Dept	Dept	NNP
cord-015021-pol2qm74	881	20	of	of	IN
cord-015021-pol2qm74	881	21	Surgery	Surgery	NNP
cord-015021-pol2qm74	881	22	,	,	,
cord-015021-pol2qm74	881	23	RCSI	RCSI	NNP
cord-015021-pol2qm74	881	24	,	,	,
cord-015021-pol2qm74	881	25	Beaumont	Beaumont	NNP
cord-015021-pol2qm74	881	26	Hospital	Hospital	NNP
cord-015021-pol2qm74	881	27	,	,	,
cord-015021-pol2qm74	881	28	Dublin	Dublin	NNP
cord-015021-pol2qm74	881	29	9	9	CD
cord-015021-pol2qm74	881	30	,	,	,
cord-015021-pol2qm74	881	31	Ireland	Ireland	NNP
cord-015021-pol2qm74	881	32	Brlke	Brlke	NNP
cord-015021-pol2qm74	881	33	E	E	NNP
cord-015021-pol2qm74	881	34	,	,	,
cord-015021-pol2qm74	881	35	Berger	Berger	NNP
cord-015021-pol2qm74	881	36	D	D	NNP
cord-015021-pol2qm74	881	37	,	,	,
cord-015021-pol2qm74	881	38	Staneseu	Staneseu	NNP
cord-015021-pol2qm74	881	39	A	A	NNP
cord-015021-pol2qm74	881	40	,	,	,
cord-015021-pol2qm74	881	41	ButtenschSn	ButtenschSn	NNP
cord-015021-pol2qm74	881	42	K	K	NNP
cord-015021-pol2qm74	881	43	,	,	,
cord-015021-pol2qm74	881	44	Vasilescu	Vasilescu	NNP
cord-015021-pol2qm74	881	45	C	C	NNP
cord-015021-pol2qm74	881	46	,	,	,
cord-015021-pol2qm74	881	47	Seidelmann	Seidelmann	NNP
cord-015021-pol2qm74	881	48	M	M	NNP
cord-015021-pol2qm74	881	49	,	,	,
cord-015021-pol2qm74	881	50	Beger	Beger	NNP
cord-015021-pol2qm74	881	51	HG	HG	NNP
cord-015021-pol2qm74	882	1	In	in	IN
cord-015021-pol2qm74	882	2	32	32	CD
cord-015021-pol2qm74	882	3	patients	patient	NNS
cord-015021-pol2qm74	882	4	undergoing	undergo	VBG
cord-015021-pol2qm74	882	5	a	a	DT
cord-015021-pol2qm74	882	6	colonoscopy	colonoscopy	NN
cord-015021-pol2qm74	882	7	,	,	,
cord-015021-pol2qm74	882	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	882	9	,	,	,
cord-015021-pol2qm74	882	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	882	11	neutralizing	neutralize	VBG
cord-015021-pol2qm74	882	12	capacity	capacity	NN
cord-015021-pol2qm74	882	13	(	(	-LRB-
cord-015021-pol2qm74	882	14	ENC	ENC	NNP
cord-015021-pol2qm74	882	15	)	)	-RRB-
cord-015021-pol2qm74	882	16	,	,	,
cord-015021-pol2qm74	882	17	thromboxane	thromboxane	NN
cord-015021-pol2qm74	882	18	B	b	NN
cord-015021-pol2qm74	882	19	o	o	NN
cord-015021-pol2qm74	882	20	(	(	-LRB-
cord-015021-pol2qm74	882	21	stabile	stabile	JJ
cord-015021-pol2qm74	882	22	metabolite	metabolite	NN
cord-015021-pol2qm74	882	23	of	of	IN
cord-015021-pol2qm74	882	24	tbmomboxane	tbmomboxane	NNP
cord-015021-pol2qm74	882	25	~	~	NFP
cord-015021-pol2qm74	882	26	)	)	-RRB-
cord-015021-pol2qm74	882	27	,	,	,
cord-015021-pol2qm74	882	28	6-Keto	6-keto	CD
cord-015021-pol2qm74	882	29	-	-	HYPH
cord-015021-pol2qm74	882	30	prostaglanSin	prostaglanSin	NNP
cord-015021-pol2qm74	882	31	,	,	,
cord-015021-pol2qm74	882	32	leueotriene	leueotriene	NNP
cord-015021-pol2qm74	882	33	C4	C4	NNP
cord-015021-pol2qm74	882	34	,	,	,
cord-015021-pol2qm74	882	35	interleukin	interleukin	NN
cord-015021-pol2qm74	882	36	6	6	CD
cord-015021-pol2qm74	882	37	and	and	CC
cord-015021-pol2qm74	882	38	the	the	DT
cord-015021-pol2qm74	882	39	incidence	incidence	NN
cord-015021-pol2qm74	882	40	of	of	IN
cord-015021-pol2qm74	882	41	bacteremia	bacteremia	NN
cord-015021-pol2qm74	882	42	were	be	VBD
cord-015021-pol2qm74	882	43	determined	determine	VBN
cord-015021-pol2qm74	882	44	before	before	RB
cord-015021-pol2qm74	882	45	and	and	CC
cord-015021-pol2qm74	882	46	then	then	RB
cord-015021-pol2qm74	882	47	every	every	DT
cord-015021-pol2qm74	882	48	five	five	CD
cord-015021-pol2qm74	882	49	minutes	minute	NNS
cord-015021-pol2qm74	882	50	during	during	IN
cord-015021-pol2qm74	882	51	the	the	DT
cord-015021-pol2qm74	882	52	procedure	procedure	NN
cord-015021-pol2qm74	882	53	.	.	.
cord-015021-pol2qm74	883	1	Twenty	twenty	CD
cord-015021-pol2qm74	883	2	-	-	HYPH
cord-015021-pol2qm74	883	3	one	one	CD
cord-015021-pol2qm74	883	4	of	of	IN
cord-015021-pol2qm74	883	5	32	32	CD
cord-015021-pol2qm74	883	6	patients	patient	NNS
cord-015021-pol2qm74	883	7	showed	show	VBD
cord-015021-pol2qm74	883	8	a	a	DT
cord-015021-pol2qm74	883	9	significant	significant	JJ
cord-015021-pol2qm74	883	10	increase	increase	NN
cord-015021-pol2qm74	883	11	of	of	IN
cord-015021-pol2qm74	883	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	883	13	plasma	plasma	NN
cord-015021-pol2qm74	883	14	levels	level	NNS
cord-015021-pol2qm74	883	15	during	during	IN
cord-015021-pol2qm74	883	16	colonoscopy	colonoscopy	NN
cord-015021-pol2qm74	883	17	(	(	-LRB-
cord-015021-pol2qm74	883	18	p=0.003	p=0.003	NNP
cord-015021-pol2qm74	883	19	)	)	-RRB-
cord-015021-pol2qm74	883	20	,	,	,
cord-015021-pol2qm74	883	21	whereas	whereas	IN
cord-015021-pol2qm74	883	22	only	only	RB
cord-015021-pol2qm74	883	23	one	one	CD
cord-015021-pol2qm74	883	24	patient	patient	NN
cord-015021-pol2qm74	883	25	had	have	VBD
cord-015021-pol2qm74	883	26	a	a	DT
cord-015021-pol2qm74	883	27	positive	positive	JJ
cord-015021-pol2qm74	883	28	blood	blood	NN
cord-015021-pol2qm74	883	29	culture	culture	NN
cord-015021-pol2qm74	883	30	with	with	IN
cord-015021-pol2qm74	883	31	bacteria	bacteria	NNS
cord-015021-pol2qm74	883	32	obviously	obviously	RB
cord-015021-pol2qm74	883	33	derived	derive	VBN
cord-015021-pol2qm74	883	34	from	from	IN
cord-015021-pol2qm74	883	35	the	the	DT
cord-015021-pol2qm74	883	36	gastro	gastro	JJ
cord-015021-pol2qm74	883	37	-	-	JJ
cord-015021-pol2qm74	883	38	intestinal	intestinal	JJ
cord-015021-pol2qm74	883	39	tract	tract	NN
cord-015021-pol2qm74	883	40	.	.	.
cord-015021-pol2qm74	884	1	The	the	DT
cord-015021-pol2qm74	884	2	ENC	ENC	NNP
cord-015021-pol2qm74	884	3	decreased	decrease	VBD
cord-015021-pol2qm74	884	4	significantly	significantly	RB
cord-015021-pol2qm74	884	5	five	five	CD
cord-015021-pol2qm74	884	6	minutes	minute	NNS
cord-015021-pol2qm74	884	7	after	after	IN
cord-015021-pol2qm74	884	8	the	the	DT
cord-015021-pol2qm74	884	9	beginning	beginning	NN
cord-015021-pol2qm74	884	10	of	of	IN
cord-015021-pol2qm74	884	11	eolonoscopy	eolonoscopy	NN
cord-015021-pol2qm74	884	12	and	and	CC
cord-015021-pol2qm74	884	13	was	be	VBD
cord-015021-pol2qm74	884	14	diminished	diminish	VBN
cord-015021-pol2qm74	884	15	further	further	RB
cord-015021-pol2qm74	884	16	thereafter	thereafter	RB
cord-015021-pol2qm74	884	17	.	.	.
cord-015021-pol2qm74	885	1	The	the	DT
cord-015021-pol2qm74	885	2	baseline	baseline	JJ
cord-015021-pol2qm74	885	3	values	value	NNS
cord-015021-pol2qm74	885	4	were	be	VBD
cord-015021-pol2qm74	885	5	reached	reach	VBN
cord-015021-pol2qm74	885	6	after	after	IN
cord-015021-pol2qm74	885	7	24	24	CD
cord-015021-pol2qm74	885	8	hours	hour	NNS
cord-015021-pol2qm74	885	9	.	.	.
cord-015021-pol2qm74	886	1	~hromboxane	~hromboxane	NFP
cord-015021-pol2qm74	887	1	B	b	NN
cord-015021-pol2qm74	887	2	o	o	NN
cord-015021-pol2qm74	887	3	levels	level	NNS
cord-015021-pol2qm74	887	4	also	also	RB
cord-015021-pol2qm74	887	5	increased	increase	VBD
cord-015021-pol2qm74	887	6	after	after	IN
cord-015021-pol2qm74	887	7	five	five	CD
cord-015021-pol2qm74	887	8	min	min	NN
cord-015021-pol2qm74	887	9	.	.	.
cord-015021-pol2qm74	888	1	from	from	IN
cord-015021-pol2qm74	888	2	89	89	CD
cord-015021-pol2qm74	889	1	to	to	IN
cord-015021-pol2qm74	889	2	376	376	CD
cord-015021-pol2qm74	889	3	pgYml	pgyml	NN
cord-015021-pol2qm74	889	4	peaking	peak	VBG
cord-015021-pol2qm74	889	5	at	at	IN
cord-015021-pol2qm74	889	6	30	30	CD
cord-015021-pol2qm74	889	7	min	min	NN
cord-015021-pol2qm74	889	8	.	.	.
cord-015021-pol2qm74	890	1	with	with	IN
cord-015021-pol2qm74	890	2	1332	1332	CD
cord-015021-pol2qm74	890	3	pg	pg	NNP
cord-015021-pol2qm74	890	4	/	/	SYM
cord-015021-pol2qm74	890	5	ml	ml	NN
cord-015021-pol2qm74	890	6	.	.	.
cord-015021-pol2qm74	891	1	6-Keto	6-keto	CD
cord-015021-pol2qm74	892	1	-prostaglandin	-prostaglandin	.
cord-015021-pol2qm74	893	1	,	,	,
cord-015021-pol2qm74	893	2	leucotriene	leucotriene	NNP
cord-015021-pol2qm74	893	3	C	C	NNP
cord-015021-pol2qm74	893	4	4	4	CD
cord-015021-pol2qm74	893	5	,	,	,
cord-015021-pol2qm74	893	6	Ii-6	Ii-6	NNP
cord-015021-pol2qm74	893	7	and	and	CC
cord-015021-pol2qm74	893	8	CRP	CRP	NNP
cord-015021-pol2qm74	893	9	remained	remain	VBD
cord-015021-pol2qm74	893	10	unchanged	unchanged	JJ
cord-015021-pol2qm74	893	11	.	.	.
cord-015021-pol2qm74	894	1	A	a	DT
cord-015021-pol2qm74	894	2	control	control	NN
cord-015021-pol2qm74	894	3	group	group	NN
cord-015021-pol2qm74	894	4	of	of	IN
cord-015021-pol2qm74	894	5	i0	i0	NN
cord-015021-pol2qm74	894	6	volunteers	volunteer	NNS
cord-015021-pol2qm74	894	7	who	who	WP
cord-015021-pol2qm74	894	8	were	be	VBD
cord-015021-pol2qm74	894	9	not	not	RB
cord-015021-pol2qm74	894	10	subjected	subject	VBN
cord-015021-pol2qm74	894	11	to	to	IN
cord-015021-pol2qm74	894	12	endoscopy	endoscopy	NN
cord-015021-pol2qm74	894	13	,	,	,
cord-015021-pol2qm74	894	14	were	be	VBD
cord-015021-pol2qm74	894	15	prepared	prepare	VBN
cord-015021-pol2qm74	894	16	for	for	IN
cord-015021-pol2qm74	894	17	eolonoscopy	eolonoscopy	NNP
cord-015021-pol2qm74	894	18	by	by	IN
cord-015021-pol2qm74	894	19	orthograde	orthograde	NNP
cord-015021-pol2qm74	894	20	lavage	lavage	NN
cord-015021-pol2qm74	894	21	.	.	.
cord-015021-pol2qm74	895	1	The	the	DT
cord-015021-pol2qm74	895	2	blood	blood	NN
cord-015021-pol2qm74	895	3	sampling	sampling	NN
cord-015021-pol2qm74	895	4	procedure	procedure	NN
cord-015021-pol2qm74	895	5	remained	remain	VBD
cord-015021-pol2qm74	895	6	identical	identical	JJ
cord-015021-pol2qm74	895	7	.	.	.
cord-015021-pol2qm74	896	1	No	no	DT
cord-015021-pol2qm74	896	2	differences	difference	NNS
cord-015021-pol2qm74	896	3	were	be	VBD
cord-015021-pol2qm74	896	4	seen	see	VBN
cord-015021-pol2qm74	896	5	in	in	IN
cord-015021-pol2qm74	896	6	all	all	DT
cord-015021-pol2qm74	896	7	described	describe	VBN
cord-015021-pol2qm74	896	8	parameters	parameter	NNS
cord-015021-pol2qm74	896	9	for	for	IN
cord-015021-pol2qm74	896	10	the	the	DT
cord-015021-pol2qm74	896	11	controls	control	NNS
cord-015021-pol2qm74	896	12	.	.	.
cord-015021-pol2qm74	897	1	These	these	DT
cord-015021-pol2qm74	897	2	data	datum	NNS
cord-015021-pol2qm74	897	3	show	show	VBP
cord-015021-pol2qm74	897	4	that	that	IN
cord-015021-pol2qm74	897	5	the	the	DT
cord-015021-pol2qm74	897	6	gut	gut	NN
cord-015021-pol2qm74	897	7	barrier	barrier	NN
cord-015021-pol2qm74	897	8	can	can	MD
cord-015021-pol2qm74	897	9	be	be	VB
cord-015021-pol2qm74	897	10	compromised	compromise	VBN
cord-015021-pol2qm74	897	11	by	by	IN
cord-015021-pol2qm74	897	12	mininml	mininml	JJ
cord-015021-pol2qm74	897	13	invasive	invasive	JJ
cord-015021-pol2qm74	897	14	procedures	procedure	NNS
cord-015021-pol2qm74	897	15	,	,	,
cord-015021-pol2qm74	897	16	at	at	IN
cord-015021-pol2qm74	897	17	least	least	JJS
cord-015021-pol2qm74	897	18	,	,	,
cord-015021-pol2qm74	897	19	concerning	concern	VBG
cord-015021-pol2qm74	897	20	bacterial	bacterial	JJ
cord-015021-pol2qm74	897	21	products	product	NNS
cord-015021-pol2qm74	897	22	.	.	.
cord-015021-pol2qm74	898	1	Living	live	VBG
cord-015021-pol2qm74	898	2	bacteria	bacteria	NNS
cord-015021-pol2qm74	898	3	,	,	,
cord-015021-pol2qm74	898	4	on	on	IN
cord-015021-pol2qm74	898	5	the	the	DT
cord-015021-pol2qm74	898	6	contrary	contrary	NN
cord-015021-pol2qm74	898	7	,	,	,
cord-015021-pol2qm74	898	8	do	do	VB
cord-015021-pol2qm74	898	9	not	not	RB
cord-015021-pol2qm74	898	10	pass	pass	VB
cord-015021-pol2qm74	898	11	the	the	DT
cord-015021-pol2qm74	898	12	gastro	gastro	JJ
cord-015021-pol2qm74	898	13	-	-	JJ
cord-015021-pol2qm74	898	14	intestinal	intestinal	JJ
cord-015021-pol2qm74	898	15	wall	wall	NN
cord-015021-pol2qm74	898	16	.	.	.
cord-015021-pol2qm74	899	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	899	2	,	,	,
cord-015021-pol2qm74	899	3	when	when	WRB
cord-015021-pol2qm74	899	4	determined	determine	VBN
cord-015021-pol2qm74	899	5	by	by	IN
cord-015021-pol2qm74	899	6	ENC	ENC	NNP
cord-015021-pol2qm74	899	7	,	,	,
cord-015021-pol2qm74	899	8	is	be	VBZ
cord-015021-pol2qm74	899	9	more	more	RBR
cord-015021-pol2qm74	899	10	sensitive	sensitive	JJ
cord-015021-pol2qm74	899	11	than	than	IN
cord-015021-pol2qm74	899	12	the	the	DT
cord-015021-pol2qm74	899	13	conventional	conventional	JJ
cord-015021-pol2qm74	899	14	limulus	limulus	NN
cord-015021-pol2qm74	899	15	-	-	HYPH
cord-015021-pol2qm74	899	16	amebocyte	amebocyte	NN
cord-015021-pol2qm74	899	17	-	-	HYPH
cord-015021-pol2qm74	899	18	lysate	lysate	NN
cord-015021-pol2qm74	899	19	test	test	NN
cord-015021-pol2qm74	899	20	.	.	.
cord-015021-pol2qm74	900	1	No	no	DT
cord-015021-pol2qm74	900	2	acute	acute	JJ
cord-015021-pol2qm74	900	3	-	-	HYPH
cord-015021-pol2qm74	900	4	phase	phase	NN
cord-015021-pol2qm74	900	5	reaction	reaction	NN
cord-015021-pol2qm74	900	6	was	be	VBD
cord-015021-pol2qm74	900	7	induceri	induceri	JJ
cord-015021-pol2qm74	900	8	by	by	IN
cord-015021-pol2qm74	900	9	the	the	DT
cord-015021-pol2qm74	900	10	observed	observed	JJ
cord-015021-pol2qm74	900	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	900	12	translocation	translocation	NN
cord-015021-pol2qm74	900	13	.	.	.
cord-015021-pol2qm74	901	1	It	-PRON-	PRP
cord-015021-pol2qm74	901	2	can	can	MD
cord-015021-pol2qm74	901	3	be	be	VB
cord-015021-pol2qm74	901	4	speculated	speculate	VBN
cord-015021-pol2qm74	901	5	from	from	IN
cord-015021-pol2qm74	901	6	the	the	DT
cord-015021-pol2qm74	901	7	dramatically	dramatically	RB
cord-015021-pol2qm74	901	8	enhanced	enhance	VBN
cord-015021-pol2qm74	901	9	thromboxane	thromboxane	NN
cord-015021-pol2qm74	901	10	B	b	NN
cord-015021-pol2qm74	901	11	2	2	CD
cord-015021-pol2qm74	901	12	levels	level	NNS
cord-015021-pol2qm74	901	13	,	,	,
cord-015021-pol2qm74	901	14	together	together	RB
cord-015021-pol2qm74	901	15	with	with	IN
cord-015021-pol2qm74	901	16	its	-PRON-	PRP$
cord-015021-pol2qm74	901	17	hemodynamie	hemodynamie	NN
cord-015021-pol2qm74	901	18	effects	effect	NNS
cord-015021-pol2qm74	901	19	,	,	,
cord-015021-pol2qm74	901	20	that	that	IN
cord-015021-pol2qm74	901	21	the	the	DT
cord-015021-pol2qm74	901	22	thromboxane	thromboxane	NN
cord-015021-pol2qm74	901	23	release	release	NN
cord-015021-pol2qm74	901	24	may	may	MD
cord-015021-pol2qm74	901	25	support	support	VB
cord-015021-pol2qm74	901	26	translocation	translocation	NN
cord-015021-pol2qm74	901	27	of	of	IN
cord-015021-pol2qm74	901	28	bacterial	bacterial	JJ
cord-015021-pol2qm74	901	29	products	product	NNS
cord-015021-pol2qm74	901	30	.	.	.
cord-015021-pol2qm74	902	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	902	2	is	be	VBZ
cord-015021-pol2qm74	902	3	common	common	JJ
cord-015021-pol2qm74	902	4	after	after	IN
cord-015021-pol2qm74	902	5	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	902	6	shock	shock	NN
cord-015021-pol2qm74	902	7	.	.	.
cord-015021-pol2qm74	903	1	This	this	DT
cord-015021-pol2qm74	903	2	study	study	NN
cord-015021-pol2qm74	903	3	aims	aim	VBZ
cord-015021-pol2qm74	903	4	to	to	TO
cord-015021-pol2qm74	903	5	demonstrate	demonstrate	VB
cord-015021-pol2qm74	903	6	that	that	IN
cord-015021-pol2qm74	903	7	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	903	8	shock	shock	NN
cord-015021-pol2qm74	903	9	alone	alone	RB
cord-015021-pol2qm74	903	10	can	can	MD
cord-015021-pol2qm74	903	11	promote	promote	VB
cord-015021-pol2qm74	903	12	translocation	translocation	NN
cord-015021-pol2qm74	903	13	of	of	IN
cord-015021-pol2qm74	903	14	gut	gut	NN
cord-015021-pol2qm74	903	15	bacteria	bacteria	NNS
cord-015021-pol2qm74	903	16	from	from	IN
cord-015021-pol2qm74	903	17	intestinal	intestinal	JJ
cord-015021-pol2qm74	903	18	tract	tract	NN
cord-015021-pol2qm74	903	19	to	to	IN
cord-015021-pol2qm74	903	20	its	-PRON-	PRP$
cord-015021-pol2qm74	903	21	regional	regional	JJ
cord-015021-pol2qm74	903	22	nodes	node	NNS
cord-015021-pol2qm74	903	23	and	and	CC
cord-015021-pol2qm74	903	24	subsequently	subsequently	RB
cord-015021-pol2qm74	903	25	to	to	IN
cord-015021-pol2qm74	903	26	blood	blood	NN
cord-015021-pol2qm74	903	27	.	.	.
cord-015021-pol2qm74	904	1	One	one	CD
cord-015021-pol2qm74	904	2	hundred	hundred	CD
cord-015021-pol2qm74	904	3	twenty	twenty	CD
cord-015021-pol2qm74	904	4	mice	mouse	NNS
cord-015021-pol2qm74	904	5	,	,	,
cord-015021-pol2qm74	904	6	divided	divide	VBN
cord-015021-pol2qm74	904	7	into	into	IN
cord-015021-pol2qm74	904	8	4	4	CD
cord-015021-pol2qm74	904	9	groups	group	NNS
cord-015021-pol2qm74	904	10	were	be	VBD
cord-015021-pol2qm74	904	11	subjected	subject	VBN
cord-015021-pol2qm74	904	12	to	to	IN
cord-015021-pol2qm74	904	13	30	30	CD
cord-015021-pol2qm74	904	14	,	,	,
cord-015021-pol2qm74	904	15	60	60	CD
cord-015021-pol2qm74	904	16	and	and	CC
cord-015021-pol2qm74	904	17	120	120	CD
cord-015021-pol2qm74	904	18	minutes	minute	NNS
cord-015021-pol2qm74	904	19	of	of	IN
cord-015021-pol2qm74	904	20	20	20	CD
cord-015021-pol2qm74	904	21	%	%	NN
cord-015021-pol2qm74	904	22	,	,	,
cord-015021-pol2qm74	904	23	30	30	CD
cord-015021-pol2qm74	904	24	%	%	NN
cord-015021-pol2qm74	904	25	and	and	CC
cord-015021-pol2qm74	904	26	40	40	CD
cord-015021-pol2qm74	904	27	%	%	NN
cord-015021-pol2qm74	904	28	of	of	IN
cord-015021-pol2qm74	904	29	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	904	30	shock	shock	NN
cord-015021-pol2qm74	904	31	.	.	.
cord-015021-pol2qm74	905	1	On	on	IN
cord-015021-pol2qm74	905	2	the	the	DT
cord-015021-pol2qm74	905	3	specified	specify	VBN
cord-015021-pol2qm74	905	4	time	time	NN
cord-015021-pol2qm74	905	5	,	,	,
cord-015021-pol2qm74	905	6	blood	blood	NN
cord-015021-pol2qm74	905	7	cultures	culture	NNS
cord-015021-pol2qm74	905	8	were	be	VBD
cord-015021-pol2qm74	905	9	taken	take	VBN
cord-015021-pol2qm74	905	10	and	and	CC
cord-015021-pol2qm74	905	11	mice	mouse	NNS
cord-015021-pol2qm74	905	12	were	be	VBD
cord-015021-pol2qm74	905	13	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	905	14	.	.	.
cord-015021-pol2qm74	906	1	The	the	DT
cord-015021-pol2qm74	906	2	intestinal	intestinal	JJ
cord-015021-pol2qm74	906	3	tract	tract	NN
cord-015021-pol2qm74	906	4	were	be	VBD
cord-015021-pol2qm74	906	5	histologically	histologically	RB
cord-015021-pol2qm74	906	6	examined	examine	VBN
cord-015021-pol2qm74	906	7	for	for	IN
cord-015021-pol2qm74	906	8	any	any	DT
cord-015021-pol2qm74	906	9	changes	change	NNS
cord-015021-pol2qm74	906	10	which	which	WDT
cord-015021-pol2qm74	906	11	allows	allow	VBZ
cord-015021-pol2qm74	906	12	translocation	translocation	NN
cord-015021-pol2qm74	906	13	and	and	CC
cord-015021-pol2qm74	906	14	its	-PRON-	PRP$
cord-015021-pol2qm74	906	15	regional	regional	JJ
cord-015021-pol2qm74	906	16	nodes	node	NNS
cord-015021-pol2qm74	906	17	were	be	VBD
cord-015021-pol2qm74	906	18	quantitatively	quantitatively	RB
cord-015021-pol2qm74	906	19	cultured	culture	VBN
cord-015021-pol2qm74	906	20	for	for	IN
cord-015021-pol2qm74	906	21	translocated	translocate	VBN
cord-015021-pol2qm74	906	22	bacteria	bacteria	NNS
cord-015021-pol2qm74	906	23	.	.	.
cord-015021-pol2qm74	907	1	There	there	EX
cord-015021-pol2qm74	907	2	was	be	VBD
cord-015021-pol2qm74	907	3	a	a	DT
cord-015021-pol2qm74	907	4	direct	direct	JJ
cord-015021-pol2qm74	907	5	relationship	relationship	NN
cord-015021-pol2qm74	907	6	between	between	IN
cord-015021-pol2qm74	907	7	duration	duration	NN
cord-015021-pol2qm74	907	8	and	and	CC
cord-015021-pol2qm74	907	9	degree	degree	NN
cord-015021-pol2qm74	907	10	of	of	IN
cord-015021-pol2qm74	907	11	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	907	12	shock	shock	NN
cord-015021-pol2qm74	907	13	and	and	CC
cord-015021-pol2qm74	907	14	incidence	incidence	NN
cord-015021-pol2qm74	907	15	of	of	IN
cord-015021-pol2qm74	907	16	translocation	translocation	NN
cord-015021-pol2qm74	907	17	(	(	-LRB-
cord-015021-pol2qm74	907	18	p	p	NN
cord-015021-pol2qm74	907	19	0.05	0.05	CD
cord-015021-pol2qm74	907	20	)	)	-RRB-
cord-015021-pol2qm74	907	21	.	.	.
cord-015021-pol2qm74	908	1	There	there	EX
cord-015021-pol2qm74	908	2	was	be	VBD
cord-015021-pol2qm74	908	3	a	a	DT
cord-015021-pol2qm74	908	4	high	high	JJ
cord-015021-pol2qm74	908	5	incidence	incidence	NN
cord-015021-pol2qm74	908	6	of	of	IN
cord-015021-pol2qm74	908	7	gut	gut	NN
cord-015021-pol2qm74	908	8	bacterial	bacterial	JJ
cord-015021-pol2qm74	908	9	translocation	translocation	NN
cord-015021-pol2qm74	908	10	to	to	IN
cord-015021-pol2qm74	908	11	the	the	DT
cord-015021-pol2qm74	908	12	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	908	13	and	and	CC
cord-015021-pol2qm74	908	14	mesocolic	mesocolic	JJ
cord-015021-pol2qm74	908	15	nodes	node	NNS
cord-015021-pol2qm74	908	16	in	in	IN
cord-015021-pol2qm74	908	17	all	all	DT
cord-015021-pol2qm74	908	18	degrees	degree	NNS
cord-015021-pol2qm74	908	19	of	of	IN
cord-015021-pol2qm74	908	20	shock	shock	NN
cord-015021-pol2qm74	908	21	(	(	-LRB-
cord-015021-pol2qm74	908	22	p	p	NN
cord-015021-pol2qm74	908	23	0.05	0.05	CD
cord-015021-pol2qm74	908	24	)	)	-RRB-
cord-015021-pol2qm74	908	25	.	.	.
cord-015021-pol2qm74	909	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	909	2	growth	growth	NN
cord-015021-pol2qm74	909	3	in	in	IN
cord-015021-pol2qm74	909	4	the	the	DT
cord-015021-pol2qm74	909	5	regional	regional	JJ
cord-015021-pol2qm74	909	6	intestinal	intestinal	JJ
cord-015021-pol2qm74	909	7	nodes	node	NNS
cord-015021-pol2qm74	909	8	increased	increase	VBD
cord-015021-pol2qm74	909	9	and	and	CC
cord-015021-pol2qm74	909	10	blood	blood	NN
cord-015021-pol2qm74	909	11	cultures	culture	NNS
cord-015021-pol2qm74	909	12	were	be	VBD
cord-015021-pol2qm74	909	13	positive	positive	JJ
cord-015021-pol2qm74	909	14	in	in	IN
cord-015021-pol2qm74	909	15	direct	direct	JJ
cord-015021-pol2qm74	909	16	proportion	proportion	NN
cord-015021-pol2qm74	909	17	to	to	IN
cord-015021-pol2qm74	909	18	degree	degree	NN
cord-015021-pol2qm74	909	19	and	and	CC
cord-015021-pol2qm74	909	20	duration	duration	NN
cord-015021-pol2qm74	909	21	of	of	IN
cord-015021-pol2qm74	909	22	shock	shock	NN
cord-015021-pol2qm74	909	23	.	.	.
cord-015021-pol2qm74	910	1	Histologic	Histologic	NNP
cord-015021-pol2qm74	910	2	evaluation	evaluation	NN
cord-015021-pol2qm74	910	3	of	of	IN
cord-015021-pol2qm74	910	4	segments	segment	NNS
cord-015021-pol2qm74	910	5	of	of	IN
cord-015021-pol2qm74	910	6	GIT	GIT	NNP
cord-015021-pol2qm74	910	7	showed	show	VBD
cord-015021-pol2qm74	910	8	submucosal	submucosal	NNP
cord-015021-pol2qm74	910	9	congestion	congestion	NN
cord-015021-pol2qm74	910	10	to	to	TO
cord-015021-pol2qm74	910	11	allow	allow	VB
cord-015021-pol2qm74	910	12	bacteria	bacteria	NNS
cord-015021-pol2qm74	910	13	normally	normally	RB
cord-015021-pol2qm74	910	14	contained	contain	VBN
cord-015021-pol2qm74	910	15	within	within	IN
cord-015021-pol2qm74	910	16	the	the	DT
cord-015021-pol2qm74	910	17	gut	gut	NN
cord-015021-pol2qm74	910	18	to	to	TO
cord-015021-pol2qm74	910	19	cause	cause	VB
cord-015021-pol2qm74	910	20	systemic	systemic	JJ
cord-015021-pol2qm74	910	21	infections	infection	NNS
cord-015021-pol2qm74	910	22	.	.	.
cord-015021-pol2qm74	911	1	Translocation	translocation	NN
cord-015021-pol2qm74	911	2	of	of	IN
cord-015021-pol2qm74	911	3	gut	gut	NN
cord-015021-pol2qm74	911	4	bacteria	bacteria	NNS
cord-015021-pol2qm74	911	5	in	in	IN
cord-015021-pol2qm74	911	6	untreated	untreated	JJ
cord-015021-pol2qm74	911	7	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	911	8	shock	shock	NN
cord-015021-pol2qm74	911	9	is	be	VBZ
cord-015021-pol2qm74	911	10	clearly	clearly	RB
cord-015021-pol2qm74	911	11	shown	show	VBN
cord-015021-pol2qm74	911	12	in	in	IN
cord-015021-pol2qm74	911	13	this	this	DT
cord-015021-pol2qm74	911	14	study	study	NN
cord-015021-pol2qm74	911	15	on	on	IN
cord-015021-pol2qm74	911	16	animal	animal	NN
cord-015021-pol2qm74	911	17	models	model	NNS
cord-015021-pol2qm74	911	18	.	.	.
cord-015021-pol2qm74	912	1	In	in	IN
cord-015021-pol2qm74	912	2	this	this	DT
cord-015021-pol2qm74	912	3	study	study	NN
cord-015021-pol2qm74	912	4	,	,	,
cord-015021-pol2qm74	912	5	guotobiotic	guotobiotic	JJ
cord-015021-pol2qm74	912	6	rats	rat	NNS
cord-015021-pol2qm74	912	7	with	with	IN
cord-015021-pol2qm74	912	8	5	5	CD
cord-015021-pol2qm74	912	9	known	know	VBN
cord-015021-pol2qm74	912	10	species	specie	NNS
cord-015021-pol2qm74	912	11	of	of	IN
cord-015021-pol2qm74	912	12	bacteria	bacteria	NNS
cord-015021-pol2qm74	912	13	were	be	VBD
cord-015021-pol2qm74	912	14	subjected	subject	VBN
cord-015021-pol2qm74	912	15	to	to	TO
cord-015021-pol2qm74	912	16	total	total	VB
cord-015021-pol2qm74	912	17	parenteral	parenteral	JJ
cord-015021-pol2qm74	912	18	nutrition(TPN	nutrition(tpn	NN
cord-015021-pol2qm74	912	19	)	)	-RRB-
cord-015021-pol2qm74	912	20	and	and	CC
cord-015021-pol2qm74	912	21	subsequent	subsequent	JJ
cord-015021-pol2qm74	912	22	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	912	23	shock	shock	NN
cord-015021-pol2qm74	912	24	.	.	.
cord-015021-pol2qm74	913	1	The	the	DT
cord-015021-pol2qm74	913	2	purpose	purpose	NN
cord-015021-pol2qm74	913	3	of	of	IN
cord-015021-pol2qm74	913	4	the	the	DT
cord-015021-pol2qm74	913	5	study	study	NN
cord-015021-pol2qm74	913	6	was	be	VBD
cord-015021-pol2qm74	913	7	to	to	TO
cord-015021-pol2qm74	913	8	observe	observe	VB
cord-015021-pol2qm74	913	9	the	the	DT
cord-015021-pol2qm74	913	10	impairment	impairment	NN
cord-015021-pol2qm74	913	11	of	of	IN
cord-015021-pol2qm74	913	12	gut	gut	NN
cord-015021-pol2qm74	913	13	barrier	barrier	NN
cord-015021-pol2qm74	913	14	function	function	NN
cord-015021-pol2qm74	913	15	following	follow	VBG
cord-015021-pol2qm74	913	16	TPN	TPN	NNP
cord-015021-pol2qm74	913	17	and	and	CC
cord-015021-pol2qm74	913	18	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	913	19	shock	shock	NN
cord-015021-pol2qm74	913	20	and	and	CC
cord-015021-pol2qm74	913	21	to	to	TO
cord-015021-pol2qm74	913	22	study	study	VB
cord-015021-pol2qm74	913	23	the	the	DT
cord-015021-pol2qm74	913	24	mechanism	mechanism	NN
cord-015021-pol2qm74	913	25	of	of	IN
cord-015021-pol2qm74	913	26	enterogenic	enterogenic	NNP
cord-015021-pol2qm74	913	27	infection	infection	NN
cord-015021-pol2qm74	913	28	induced	induce	VBN
cord-015021-pol2qm74	913	29	by	by	IN
cord-015021-pol2qm74	913	30	TPN	TPN	NNP
cord-015021-pol2qm74	913	31	and	and	CC
cord-015021-pol2qm74	913	32	shock	shock	NN
cord-015021-pol2qm74	913	33	.	.	.
cord-015021-pol2qm74	914	1	The	the	DT
cord-015021-pol2qm74	914	2	results	result	NNS
cord-015021-pol2qm74	914	3	were	be	VBD
cord-015021-pol2qm74	914	4	as	as	IN
cord-015021-pol2qm74	914	5	follows	follow	VBZ
cord-015021-pol2qm74	914	6	:	:	:
cord-015021-pol2qm74	914	7	1.Long	1.long	CD
cord-015021-pol2qm74	914	8	term(8	term(8	CD
cord-015021-pol2qm74	914	9	-	-	SYM
cord-015021-pol2qm74	914	10	12	12	CD
cord-015021-pol2qm74	914	11	days	day	NNS
cord-015021-pol2qm74	914	12	)	)	-RRB-
cord-015021-pol2qm74	915	1	TPN	TPN	NNP
cord-015021-pol2qm74	915	2	induced	induce	VBN
cord-015021-pol2qm74	915	3	impairment	impairment	NN
cord-015021-pol2qm74	915	4	of	of	IN
cord-015021-pol2qm74	915	5	gut	gut	NN
cord-015021-pol2qm74	915	6	barrier	barrier	NN
cord-015021-pol2qm74	915	7	function	function	NN
cord-015021-pol2qm74	915	8	,	,	,
cord-015021-pol2qm74	915	9	evidenced	evidence	VBN
cord-015021-pol2qm74	915	10	by	by	IN
cord-015021-pol2qm74	915	11	atrophy	atrophy	NN
cord-015021-pol2qm74	915	12	of	of	IN
cord-015021-pol2qm74	915	13	intestinal	intestinal	JJ
cord-015021-pol2qm74	915	14	mucosa	mucosa	NN
cord-015021-pol2qm74	915	15	,	,	,
cord-015021-pol2qm74	915	16	significant	significant	JJ
cord-015021-pol2qm74	915	17	decrease	decrease	NN
cord-015021-pol2qm74	915	18	in	in	IN
cord-015021-pol2qm74	915	19	diamine	diamine	NN
cord-015021-pol2qm74	915	20	oxidase	oxidase	NN
cord-015021-pol2qm74	915	21	activity	activity	NN
cord-015021-pol2qm74	915	22	of	of	IN
cord-015021-pol2qm74	915	23	intestinal	intestinal	JJ
cord-015021-pol2qm74	915	24	mucosa	mucosa	NN
cord-015021-pol2qm74	915	25	and	and	CC
cord-015021-pol2qm74	915	26	blood	blood	NN
cord-015021-pol2qm74	915	27	,	,	,
cord-015021-pol2qm74	915	28	and	and	CC
cord-015021-pol2qm74	915	29	marked	mark	VBD
cord-015021-pol2qm74	915	30	microecologic	microecologic	JJ
cord-015021-pol2qm74	915	31	imbalance	imbalance	NN
cord-015021-pol2qm74	915	32	of	of	IN
cord-015021-pol2qm74	915	33	the	the	DT
cord-015021-pol2qm74	915	34	intestinal	intestinal	JJ
cord-015021-pol2qm74	915	35	mucosa	mucosa	NN
cord-015021-pol2qm74	915	36	flora	flora	NNS
cord-015021-pol2qm74	915	37	with	with	IN
cord-015021-pol2qm74	915	38	dorminant	dorminant	JJ
cord-015021-pol2qm74	915	39	growth	growth	NN
cord-015021-pol2qm74	915	40	of	of	IN
cord-015021-pol2qm74	915	41	aerobes	aerobe	NNS
cord-015021-pol2qm74	915	42	and	and	CC
cord-015021-pol2qm74	915	43	relative	relative	JJ
cord-015021-pol2qm74	915	44	decrease	decrease	NN
cord-015021-pol2qm74	915	45	in	in	IN
cord-015021-pol2qm74	915	46	anaerobes	anaerobe	NNS
cord-015021-pol2qm74	915	47	.	.	.
cord-015021-pol2qm74	916	1	The	the	DT
cord-015021-pol2qm74	916	2	degree	degree	NN
cord-015021-pol2qm74	916	3	of	of	IN
cord-015021-pol2qm74	916	4	mucosal	mucosal	JJ
cord-015021-pol2qm74	916	5	damage	damage	NN
cord-015021-pol2qm74	916	6	were	be	VBD
cord-015021-pol2qm74	916	7	proportional	proportional	JJ
cord-015021-pol2qm74	916	8	to	to	IN
cord-015021-pol2qm74	916	9	the	the	DT
cord-015021-pol2qm74	916	10	duration	duration	NN
cord-015021-pol2qm74	916	11	of	of	IN
cord-015021-pol2qm74	916	12	TPN	TPN	NNP
cord-015021-pol2qm74	916	13	.	.	.
cord-015021-pol2qm74	917	1	2.In	2.in	CD
cord-015021-pol2qm74	917	2	TPN+shock	TPN+shock	NNP
cord-015021-pol2qm74	917	3	groups	group	NNS
cord-015021-pol2qm74	917	4	,	,	,
cord-015021-pol2qm74	917	5	failure	failure	NN
cord-015021-pol2qm74	917	6	of	of	IN
cord-015021-pol2qm74	917	7	gut	gut	NN
cord-015021-pol2qm74	917	8	barrier	barrier	NN
cord-015021-pol2qm74	917	9	function	function	NN
cord-015021-pol2qm74	917	10	was	be	VBD
cord-015021-pol2qm74	917	11	found	find	VBN
cord-015021-pol2qm74	917	12	.	.	.
cord-015021-pol2qm74	918	1	ri,~ere	ri,~ere	NNP
cord-015021-pol2qm74	918	2	were	be	VBD
cord-015021-pol2qm74	918	3	further	further	JJ
cord-015021-pol2qm74	918	4	damage	damage	NN
cord-015021-pol2qm74	918	5	in	in	IN
cord-015021-pol2qm74	918	6	the	the	DT
cord-015021-pol2qm74	918	7	mucosa	mucosa	NN
cord-015021-pol2qm74	918	8	,	,	,
cord-015021-pol2qm74	918	9	with	with	IN
cord-015021-pol2qm74	918	10	a	a	DT
cord-015021-pol2qm74	918	11	large	large	JJ
cord-015021-pol2qm74	918	12	number	number	NN
cord-015021-pol2qm74	918	13	of	of	IN
cord-015021-pol2qm74	918	14	gramnegative	gramnegative	JJ
cord-015021-pol2qm74	918	15	organisms	organism	NNS
cord-015021-pol2qm74	918	16	invading	invade	VBG
cord-015021-pol2qm74	918	17	mucosa	mucosa	JJ
cord-015021-pol2qm74	918	18	and	and	CC
cord-015021-pol2qm74	918	19	submucosa	submucosa	NNS
cord-015021-pol2qm74	918	20	and	and	CC
cord-015021-pol2qm74	918	21	a	a	DT
cord-015021-pol2qm74	918	22	significant	significant	JJ
cord-015021-pol2qm74	918	23	decrease	decrease	NN
cord-015021-pol2qm74	918	24	in	in	IN
cord-015021-pol2qm74	918	25	DAO	DAO	NNP
cord-015021-pol2qm74	918	26	activity	activity	NN
cord-015021-pol2qm74	918	27	as	as	IN
cord-015021-pol2qm74	918	28	compared	compare	VBN
cord-015021-pol2qm74	918	29	with	with	IN
cord-015021-pol2qm74	918	30	each	each	DT
cord-015021-pol2qm74	918	31	relative	relative	JJ
cord-015021-pol2qm74	918	32	TPN	TPN	NNP
cord-015021-pol2qm74	918	33	groups	group	NNS
cord-015021-pol2qm74	918	34	.	.	.
cord-015021-pol2qm74	919	1	These	these	DT
cord-015021-pol2qm74	919	2	changes	change	NNS
cord-015021-pol2qm74	919	3	were	be	VBD
cord-015021-pol2qm74	919	4	significantly	significantly	RB
cord-015021-pol2qm74	919	5	correlated	correlate	VBN
cord-015021-pol2qm74	919	6	with	with	IN
cord-015021-pol2qm74	919	7	enhanced	enhanced	JJ
cord-015021-pol2qm74	919	8	bacterial	bacterial	JJ
cord-015021-pol2qm74	919	9	translocation	translocation	NN
cord-015021-pol2qm74	919	10	,	,	,
cord-015021-pol2qm74	919	11	elevation	elevation	NN
cord-015021-pol2qm74	919	12	of	of	IN
cord-015021-pol2qm74	919	13	LPS	LPS	NNP
cord-015021-pol2qm74	919	14	and	and	CC
cord-015021-pol2qm74	919	15	MDA	MDA	NNP
cord-015021-pol2qm74	919	16	levels	level	NNS
cord-015021-pol2qm74	919	17	in	in	IN
cord-015021-pol2qm74	919	18	the	the	DT
cord-015021-pol2qm74	919	19	plasma	plasma	NN
cord-015021-pol2qm74	919	20	.	.	.
cord-015021-pol2qm74	920	1	These	these	DT
cord-015021-pol2qm74	920	2	findings	finding	NNS
cord-015021-pol2qm74	920	3	suggested	suggest	VBD
cord-015021-pol2qm74	920	4	that	that	IN
cord-015021-pol2qm74	920	5	long	long	JJ
cord-015021-pol2qm74	920	6	term	term	NN
cord-015021-pol2qm74	920	7	standard	standard	JJ
cord-015021-pol2qm74	920	8	TPN	TPN	NNP
cord-015021-pol2qm74	920	9	impaired	impair	VBD
cord-015021-pol2qm74	920	10	the	the	DT
cord-015021-pol2qm74	920	11	gut	gut	NN
cord-015021-pol2qm74	920	12	barrier	barrier	NN
cord-015021-pol2qm74	920	13	function	function	NN
cord-015021-pol2qm74	920	14	,	,	,
cord-015021-pol2qm74	920	15	precipitating	precipitate	VBG
cord-015021-pol2qm74	920	16	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	920	17	gut	gut	NN
cord-015021-pol2qm74	920	18	barrier	barrier	NN
cord-015021-pol2qm74	920	19	failure	failure	NN
cord-015021-pol2qm74	920	20	.	.	.
cord-015021-pol2qm74	921	1	Thus	thus	RB
cord-015021-pol2qm74	921	2	infec	infec	IN
cord-015021-pol2qm74	921	3	.	.	.
cord-015021-pol2qm74	922	1	fion	fion	NNP
cord-015021-pol2qm74	922	2	following	follow	VBG
cord-015021-pol2qm74	922	3	shock	shock	NN
cord-015021-pol2qm74	922	4	might	may	MD
cord-015021-pol2qm74	922	5	be	be	VB
cord-015021-pol2qm74	922	6	oi'iginated	oi'iginate	VBN
cord-015021-pol2qm74	922	7	from	from	IN
cord-015021-pol2qm74	922	8	the	the	DT
cord-015021-pol2qm74	922	9	gut	gut	NN
cord-015021-pol2qm74	923	1	and	and	CC
cord-015021-pol2qm74	923	2	it	-PRON-	PRP
cord-015021-pol2qm74	923	3	was	be	VBD
cord-015021-pol2qm74	923	4	obviously	obviously	RB
cord-015021-pol2qm74	923	5	related	relate	VBN
cord-015021-pol2qm74	923	6	to	to	IN
cord-015021-pol2qm74	923	7	the	the	DT
cord-015021-pol2qm74	923	8	impaired	impair	VBN
cord-015021-pol2qm74	923	9	gut	gut	NN
cord-015021-pol2qm74	923	10	defence	defence	NN
cord-015021-pol2qm74	923	11	resulted	result	VBD
cord-015021-pol2qm74	923	12	from	from	IN
cord-015021-pol2qm74	923	13	antecedent	antecedent	JJ
cord-015021-pol2qm74	923	14	TPN	TPN	NNP
cord-015021-pol2qm74	923	15	.	.	.
cord-015021-pol2qm74	924	1	The	the	DT
cord-015021-pol2qm74	924	2	determination	determination	NN
cord-015021-pol2qm74	924	3	of	of	IN
cord-015021-pol2qm74	924	4	plasma	plasma	NN
cord-015021-pol2qm74	924	5	DAO	DAO	NNP
cord-015021-pol2qm74	924	6	activity	activity	NN
cord-015021-pol2qm74	924	7	might	may	MD
cord-015021-pol2qm74	924	8	provide	provide	VB
cord-015021-pol2qm74	924	9	a	a	DT
cord-015021-pol2qm74	924	10	valuable	valuable	JJ
cord-015021-pol2qm74	924	11	tool	tool	NN
cord-015021-pol2qm74	924	12	for	for	IN
cord-015021-pol2qm74	924	13	the	the	DT
cord-015021-pol2qm74	924	14	ear	ear	NN
cord-015021-pol2qm74	924	15	.	.	.
cord-015021-pol2qm74	925	1	ly	ly	IN
cord-015021-pol2qm74	925	2	diagnosis	diagnosis	NN
cord-015021-pol2qm74	925	3	of	of	IN
cord-015021-pol2qm74	925	4	gut	gut	NN
cord-015021-pol2qm74	926	1	injut;y	injut;y	NNP
cord-015021-pol2qm74	926	2	during	during	IN
cord-015021-pol2qm74	926	3	TPN	TPN	NNP
cord-015021-pol2qm74	926	4	and	and	CC
cord-015021-pol2qm74	926	5	after	after	IN
cord-015021-pol2qm74	926	6	trauma	trauma	NN
cord-015021-pol2qm74	926	7	.	.	.
cord-015021-pol2qm74	927	1	In	in	IN
cord-015021-pol2qm74	927	2	our	-PRON-	PRP$
cord-015021-pol2qm74	927	3	earlier	early	JJR
cord-015021-pol2qm74	927	4	studies	study	NNS
cord-015021-pol2qm74	927	5	we	-PRON-	PRP
cord-015021-pol2qm74	927	6	have	have	VBP
cord-015021-pol2qm74	927	7	investigated	investigate	VBN
cord-015021-pol2qm74	927	8	the	the	DT
cord-015021-pol2qm74	927	9	dynamics	dynamic	NNS
cord-015021-pol2qm74	927	10	of	of	IN
cord-015021-pol2qm74	927	11	granuloayte	granuloayte	JJ
cord-015021-pol2qm74	927	12	infiltration	infiltration	NN
cord-015021-pol2qm74	927	13	of	of	IN
cord-015021-pol2qm74	927	14	the	the	DT
cord-015021-pol2qm74	927	15	ischemic	ischemic	JJ
cord-015021-pol2qm74	927	16	/	/	SYM
cord-015021-pol2qm74	927	17	reperfused	reperfused	JJ
cord-015021-pol2qm74	927	18	s	s	NNP
cord-015021-pol2qm74	927	19	~	~	NFP
cord-015021-pol2qm74	927	20	all	all	DT
cord-015021-pol2qm74	927	21	intestine	intestine	NN
cord-015021-pol2qm74	927	22	(	(	-LRB-
cord-015021-pol2qm74	927	23	G.	G.	NNP
cord-015021-pol2qm74	927	24	Illy	Illy	NNP
cord-015021-pol2qm74	927	25	~	~	NNP
cord-015021-pol2qm74	927	26	s	s	NNP
cord-015021-pol2qm74	927	27	,	,	,
cord-015021-pol2qm74	927	28	J.	J.	NNP
cord-015021-pol2qm74	927	29	Hamar	Hamar	NNP
cord-015021-pol2qm74	927	30	Int	Int	NNP
cord-015021-pol2qm74	927	31	.	.	NNP
cord-015021-pol2qm74	927	32	J.	J.	NNP
cord-015021-pol2qm74	927	33	Exp	Exp	NNP
cord-015021-pol2qm74	927	34	.	.	.
cord-015021-pol2qm74	928	1	9athol	9athol	CD
cord-015021-pol2qm74	928	2	.	.	.
cord-015021-pol2qm74	929	1	73	73	CD
cord-015021-pol2qm74	929	2	.	.	.
cord-015021-pol2qm74	930	1	161	161	CD
cord-015021-pol2qm74	930	2	.	.	.
cord-015021-pol2qm74	930	3	1992	1992	CD
cord-015021-pol2qm74	930	4	.	.	.
cord-015021-pol2qm74	930	5	)	)	-RRB-
cord-015021-pol2qm74	930	6	.	.	.
cord-015021-pol2qm74	931	1	There	there	EX
cord-015021-pol2qm74	931	2	was	be	VBD
cord-015021-pol2qm74	931	3	a	a	DT
cord-015021-pol2qm74	931	4	increasing	increase	VBG
cord-015021-pol2qm74	931	5	infiltration	infiltration	NN
cord-015021-pol2qm74	931	6	of	of	IN
cord-015021-pol2qm74	931	7	the	the	DT
cord-015021-pol2qm74	931	8	mucosa	mucosa	JJ
cord-015021-pol2qm74	931	9	c111m	c111m	CD
cord-015021-pol2qm74	931	10	~	~	NFP
cord-015021-pol2qm74	931	11	nating	nate	VBG
cord-015021-pol2qm74	931	12	at	at	IN
cord-015021-pol2qm74	931	13	the	the	DT
cord-015021-pol2qm74	931	14	3d	3d	NNP
cord-015021-pol2qm74	931	15	to	to	IN
cord-015021-pol2qm74	931	16	4th	4th	JJ
cord-015021-pol2qm74	931	17	hours	hour	NNS
cord-015021-pol2qm74	931	18	of	of	IN
cord-015021-pol2qm74	931	19	reperfusion	reperfusion	NN
cord-015021-pol2qm74	931	20	.	.	.
cord-015021-pol2qm74	932	1	In	in	IN
cord-015021-pol2qm74	932	2	the	the	DT
cord-015021-pol2qm74	932	3	present	present	JJ
cord-015021-pol2qm74	932	4	series	series	NN
cord-015021-pol2qm74	932	5	we	-PRON-	PRP
cord-015021-pol2qm74	932	6	have	have	VBP
cord-015021-pol2qm74	932	7	studied	study	VBN
cord-015021-pol2qm74	932	8	sc	sc	NNP
cord-015021-pol2qm74	932	9	~	~	NNP
cord-015021-pol2qm74	932	10	e	e	NNP
cord-015021-pol2qm74	932	11	of	of	IN
cord-015021-pol2qm74	932	12	the	the	DT
cord-015021-pol2qm74	932	13	conseqn	conseqn	NNP
cord-015021-pol2qm74	932	14	/	/	SYM
cord-015021-pol2qm74	932	15	ences	ence	NNS
cord-015021-pol2qm74	932	16	and	and	CC
cord-015021-pol2qm74	932	17	the	the	DT
cord-015021-pol2qm74	932	18	possible	possible	JJ
cord-015021-pol2qm74	932	19	role	role	NN
cord-015021-pol2qm74	932	20	of	of	IN
cord-015021-pol2qm74	932	21	this	this	DT
cord-015021-pol2qm74	932	22	cellular	cellular	JJ
cord-015021-pol2qm74	932	23	reaction	reaction	NN
cord-015021-pol2qm74	932	24	.	.	.
cord-015021-pol2qm74	933	1	45	45	CD
cord-015021-pol2qm74	934	1	~in	~in	NNP
cord-015021-pol2qm74	934	2	isehemia	isehemia	NNP
cord-015021-pol2qm74	934	3	was	be	VBD
cord-015021-pol2qm74	934	4	followed	follow	VBN
cord-015021-pol2qm74	934	5	by	by	IN
cord-015021-pol2qm74	934	6	a	a	DT
cord-015021-pol2qm74	934	7	4	4	CD
cord-015021-pol2qm74	934	8	hour	hour	NN
cord-015021-pol2qm74	934	9	reperfusion	reperfusion	NN
cord-015021-pol2qm74	934	10	in	in	IN
cord-015021-pol2qm74	934	11	the	the	DT
cord-015021-pol2qm74	934	12	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	934	13	rat	rat	NN
cord-015021-pol2qm74	934	14	.	.	.
cord-015021-pol2qm74	935	1	Arterial	arterial	JJ
cord-015021-pol2qm74	935	2	~/ad	~/ad	CD
cord-015021-pol2qm74	935	3	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	935	4	venous	venous	JJ
cord-015021-pol2qm74	935	5	blood	blood	NN
cord-015021-pol2qm74	935	6	samples	sample	NNS
cord-015021-pol2qm74	935	7	were	be	VBD
cord-015021-pol2qm74	935	8	collected	collect	VBN
cord-015021-pol2qm74	935	9	at	at	IN
cord-015021-pol2qm74	935	10	5	5	CD
cord-015021-pol2qm74	935	11	m_in	m_in	NN
cord-015021-pol2qm74	935	12	,	,	,
cord-015021-pol2qm74	935	13	I	-PRON-	PRP
cord-015021-pol2qm74	935	14	,	,	,
cord-015021-pol2qm74	935	15	2~	2~	CD
cord-015021-pol2qm74	935	16	3	3	CD
cord-015021-pol2qm74	935	17	,	,	,
cord-015021-pol2qm74	935	18	and	and	CC
cord-015021-pol2qm74	935	19	4	4	CD
cord-015021-pol2qm74	935	20	hours	hour	NNS
cord-015021-pol2qm74	935	21	of	of	IN
cord-015021-pol2qm74	935	22	reperfusion	reperfusion	NN
cord-015021-pol2qm74	935	23	.	.	.
cord-015021-pol2qm74	936	1	Elastase	Elastase	NNP
cord-015021-pol2qm74	936	2	and	and	CC
cord-015021-pol2qm74	936	3	lactate	lactate	NN
cord-015021-pol2qm74	936	4	concentrations	concentration	NNS
cord-015021-pol2qm74	936	5	were	be	VBD
cord-015021-pol2qm74	936	6	determined	determined	JJ
cord-015021-pol2qm74	936	7	and	and	CC
cord-015021-pol2qm74	936	8	hamoculture	hamoculture	NN
cord-015021-pol2qm74	936	9	was	be	VBD
cord-015021-pol2qm74	936	10	carried	carry	VBN
cord-015021-pol2qm74	936	11	out	out	RP
cord-015021-pol2qm74	936	12	from	from	IN
cord-015021-pol2qm74	936	13	the	the	DT
cord-015021-pol2qm74	936	14	blood	blood	NN
cord-015021-pol2qm74	936	15	samples	sample	NNS
cord-015021-pol2qm74	936	16	,	,	,
cord-015021-pol2qm74	936	17	and	and	CC
cord-015021-pol2qm74	936	18	tissue	tissue	NN
cord-015021-pol2qm74	936	19	pieces	piece	NNS
cord-015021-pol2qm74	936	20	from	from	IN
cord-015021-pol2qm74	936	21	the	the	DT
cord-015021-pol2qm74	936	22	heart	heart	NN
cord-015021-pol2qm74	936	23	,	,	,
cord-015021-pol2qm74	936	24	lung	lung	NN
cord-015021-pol2qm74	936	25	,	,	,
cord-015021-pol2qm74	936	26	liver	liver	NN
cord-015021-pol2qm74	936	27	and	and	CC
cord-015021-pol2qm74	936	28	kidney	kidney	NN
cord-015021-pol2qm74	936	29	were	be	VBD
cord-015021-pol2qm74	936	30	collected	collect	VBN
cord-015021-pol2qm74	936	31	for	for	IN
cord-015021-pol2qm74	936	32	histological	histological	JJ
cord-015021-pol2qm74	936	33	analyses	analysis	NNS
cord-015021-pol2qm74	936	34	at	at	IN
cord-015021-pol2qm74	936	35	the	the	DT
cord-015021-pol2qm74	936	36	above	above	RB
cord-015021-pol2qm74	936	37	mentioned	mention	VBN
cord-015021-pol2qm74	936	38	times	time	NNS
cord-015021-pol2qm74	936	39	of	of	IN
cord-015021-pol2qm74	936	40	reperfusion	reperfusion	NN
cord-015021-pol2qm74	936	41	.	.	.
cord-015021-pol2qm74	937	1	All	all	DT
cord-015021-pol2qm74	937	2	blood	blood	NN
cord-015021-pol2qm74	937	3	samples	sample	NNS
cord-015021-pol2qm74	937	4	were	be	VBD
cord-015021-pol2qm74	937	5	free	free	JJ
cord-015021-pol2qm74	937	6	of	of	IN
cord-015021-pol2qm74	937	7	Cell	cell	NN
cord-015021-pol2qm74	937	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	937	9	.	.	.
cord-015021-pol2qm74	938	1	Staphylococci	staphylococcus	NNS
cord-015021-pol2qm74	938	2	appeared	appear	VBD
cord-015021-pol2qm74	938	3	only	only	RB
cord-015021-pol2qm74	938	4	occasionally	occasionally	RB
cord-015021-pol2qm74	938	5	at	at	IN
cord-015021-pol2qm74	938	6	the	the	DT
cord-015021-pol2qm74	938	7	4th	4th	JJ
cord-015021-pol2qm74	938	8	hour	hour	NN
cord-015021-pol2qm74	938	9	in	in	IN
cord-015021-pol2qm74	938	10	the	the	DT
cord-015021-pol2qm74	938	11	arterial	arterial	JJ
cord-015021-pol2qm74	938	12	blood	blood	NN
cord-015021-pol2qm74	938	13	.and	.and	.
cord-015021-pol2qm74	939	1	at	at	IN
cord-015021-pol2qm74	939	2	the	the	DT
cord-015021-pol2qm74	939	3	3d	3d	JJ
cord-015021-pol2qm74	939	4	and	and	CC
cord-015021-pol2qm74	939	5	4th	4th	JJ
cord-015021-pol2qm74	939	6	hours	hour	NNS
cord-015021-pol2qm74	939	7	in	in	IN
cord-015021-pol2qm74	939	8	the	the	DT
cord-015021-pol2qm74	939	9	venous	venous	JJ
cord-015021-pol2qm74	939	10	blood	blood	NN
cord-015021-pol2qm74	939	11	,	,	,
cord-015021-pol2qm74	939	12	respectively	respectively	RB
cord-015021-pol2qm74	939	13	.	.	.
cord-015021-pol2qm74	940	1	Arterial	arterial	JJ
cord-015021-pol2qm74	940	2	and	and	CC
cord-015021-pol2qm74	940	3	venous	venous	JJ
cord-015021-pol2qm74	940	4	elastase	elastase	NN
cord-015021-pol2qm74	940	5	activities	activity	NNS
cord-015021-pol2qm74	940	6	were	be	VBD
cord-015021-pol2qm74	940	7	high	high	JJ
cord-015021-pol2qm74	940	8	throughout	throughout	IN
cord-015021-pol2qm74	940	9	the	the	DT
cord-015021-pol2qm74	940	10	reperfusion	reperfusion	NN
cord-015021-pol2qm74	940	11	,	,	,
cord-015021-pol2qm74	940	12	venous	venous	JJ
cord-015021-pol2qm74	940	13	concentrations	concentration	NNS
cord-015021-pol2qm74	940	14	being	be	VBG
cord-015021-pol2qm74	940	15	higher	high	JJR
cord-015021-pol2qm74	940	16	at	at	IN
cord-015021-pol2qm74	940	17	all	all	DT
cord-015021-pol2qm74	940	18	times	time	NNS
cord-015021-pol2qm74	940	19	.	.	.
cord-015021-pol2qm74	941	1	Lactate	lactate	NN
cord-015021-pol2qm74	941	2	concentrations	concentration	NNS
cord-015021-pol2qm74	941	3	of	of	IN
cord-015021-pol2qm74	941	4	the	the	DT
cord-015021-pol2qm74	941	5	arterial	arterial	JJ
cord-015021-pol2qm74	941	6	and	and	CC
cord-015021-pol2qm74	941	7	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	941	8	venous	venous	JJ
cord-015021-pol2qm74	941	9	blood	blood	NN
cord-015021-pol2qm74	941	10	samples	sample	NNS
cord-015021-pol2qm74	941	11	increased	increase	VBD
cord-015021-pol2qm74	941	12	during	during	IN
cord-015021-pol2qm74	941	13	shock	shock	NN
cord-015021-pol2qm74	941	14	.	.	.
cord-015021-pol2qm74	942	1	~ranuloeyte	~ranuloeyte	XX
cord-015021-pol2qm74	943	1	infiltration	infiltration	NN
cord-015021-pol2qm74	943	2	of	of	IN
cord-015021-pol2qm74	943	3	all	all	DT
cord-015021-pol2qm74	943	4	organs	organ	NNS
cord-015021-pol2qm74	943	5	studied	study	VBN
cord-015021-pol2qm74	943	6	appeared	appear	VBD
cord-015021-pol2qm74	943	7	during	during	IN
cord-015021-pol2qm74	943	8	the	the	DT
cord-015021-pol2qm74	943	9	2d	2d	NNP
cord-015021-pol2qm74	943	10	hour	hour	NN
cord-015021-pol2qm74	943	11	and	and	CC
cord-015021-pol2qm74	943	12	it	-PRON-	PRP
cord-015021-pol2qm74	943	13	increased	increase	VBD
cord-015021-pol2qm74	943	14	at	at	IN
cord-015021-pol2qm74	943	15	later	later	JJ
cord-015021-pol2qm74	943	16	times	time	NNS
cord-015021-pol2qm74	943	17	of	of	IN
cord-015021-pol2qm74	943	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	943	19	.	.	.
cord-015021-pol2qm74	944	1	It	-PRON-	PRP
cord-015021-pol2qm74	944	2	is	be	VBZ
cord-015021-pol2qm74	944	3	concluded	conclude	VBN
cord-015021-pol2qm74	944	4	that	that	IN
cord-015021-pol2qm74	944	5	heavy	heavy	JJ
cord-015021-pol2qm74	944	6	infiltration	infiltration	NN
cord-015021-pol2qm74	944	7	of	of	IN
cord-015021-pol2qm74	944	8	the	the	DT
cord-015021-pol2qm74	944	9	intestinal	intestinal	JJ
cord-015021-pol2qm74	944	10	mucosa	mucosa	NN
cord-015021-pol2qm74	944	11	can	can	MD
cord-015021-pol2qm74	944	12	block	block	VB
cord-015021-pol2qm74	944	13	bacterial	bacterial	JJ
cord-015021-pol2qm74	944	14	translocation	translocation	NN
cord-015021-pol2qm74	944	15	in	in	IN
cord-015021-pol2qm74	944	16	most	most	JJS
cord-015021-pol2qm74	944	17	of	of	IN
cord-015021-pol2qm74	944	18	the	the	DT
cord-015021-pol2qm74	944	19	cases	case	NNS
cord-015021-pol2qm74	944	20	during	during	IN
cord-015021-pol2qm74	944	21	reperfusion	reperfusion	NN
cord-015021-pol2qm74	944	22	.	.	.
cord-015021-pol2qm74	945	1	Granulocytes	granulocyte	NNS
cord-015021-pol2qm74	945	2	activated	activate	VBN
cord-015021-pol2qm74	945	3	either	either	CC
cord-015021-pol2qm74	945	4	by	by	IN
cord-015021-pol2qm74	945	5	the	the	DT
cord-015021-pol2qm74	945	6	reperfused	reperfused	JJ
cord-015021-pol2qm74	945	7	area	area	NN
cord-015021-pol2qm74	945	8	or	or	CC
cord-015021-pol2qm74	945	9	by	by	IN
cord-015021-pol2qm74	945	10	the	the	DT
cord-015021-pol2qm74	945	11	released	release	VBN
cord-015021-pol2qm74	945	12	cytokines	cytokine	NNS
cord-015021-pol2qm74	945	13	infiltrate	infiltrate	VBP
cord-015021-pol2qm74	945	14	other	other	JJ
cord-015021-pol2qm74	945	15	organs	organ	NNS
cord-015021-pol2qm74	945	16	contributing	contribute	VBG
cord-015021-pol2qm74	945	17	by	by	IN
cord-015021-pol2qm74	945	18	this	this	DT
cord-015021-pol2qm74	945	19	way	way	NN
cord-015021-pol2qm74	945	20	to	to	IN
cord-015021-pol2qm74	945	21	the	the	DT
cord-015021-pol2qm74	945	22	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	945	23	shock	shock	NN
cord-015021-pol2qm74	945	24	s!rndrc	s!rndrc	NNP
cord-015021-pol2qm74	946	1	~e	~e	NNP
cord-015021-pol2qm74	946	2	.	.	.
cord-015021-pol2qm74	947	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	947	2	motility	motility	NN
cord-015021-pol2qm74	947	3	plays	play	VBZ
cord-015021-pol2qm74	947	4	an	an	DT
cord-015021-pol2qm74	947	5	important	important	JJ
cord-015021-pol2qm74	947	6	role	role	NN
cord-015021-pol2qm74	947	7	for	for	IN
cord-015021-pol2qm74	947	8	maintaining	maintain	VBG
cord-015021-pol2qm74	947	9	nutrient	nutrient	NN
cord-015021-pol2qm74	947	10	transport	transport	NN
cord-015021-pol2qm74	947	11	and	and	CC
cord-015021-pol2qm74	947	12	absorption	absorption	NN
cord-015021-pol2qm74	947	13	and	and	CC
cord-015021-pol2qm74	947	14	for	for	IN
cord-015021-pol2qm74	947	15	balancing	balance	VBG
cord-015021-pol2qm74	947	16	the	the	DT
cord-015021-pol2qm74	947	17	enteric	enteric	JJ
cord-015021-pol2qm74	947	18	bacterial	bacterial	JJ
cord-015021-pol2qm74	947	19	population	population	NN
cord-015021-pol2qm74	947	20	.	.	.
cord-015021-pol2qm74	948	1	Disturbances	disturbance	NNS
cord-015021-pol2qm74	948	2	of	of	IN
cord-015021-pol2qm74	948	3	intestinal	intestinal	JJ
cord-015021-pol2qm74	948	4	motility	motility	NN
cord-015021-pol2qm74	948	5	may	may	MD
cord-015021-pol2qm74	948	6	be	be	VB
cord-015021-pol2qm74	948	7	one	one	CD
cord-015021-pol2qm74	948	8	of	of	IN
cord-015021-pol2qm74	948	9	the	the	DT
cord-015021-pol2qm74	948	10	earliest	early	JJS
cord-015021-pol2qm74	948	11	notable	notable	JJ
cord-015021-pol2qm74	948	12	changes	change	NNS
cord-015021-pol2qm74	948	13	in	in	IN
cord-015021-pol2qm74	948	14	intestinal	intestinal	JJ
cord-015021-pol2qm74	948	15	function	function	NN
cord-015021-pol2qm74	948	16	.	.	.
cord-015021-pol2qm74	949	1	In	in	IN
cord-015021-pol2qm74	949	2	the	the	DT
cord-015021-pol2qm74	949	3	present	present	JJ
cord-015021-pol2qm74	949	4	study	study	NN
cord-015021-pol2qm74	949	5	,	,	,
cord-015021-pol2qm74	949	6	we	-PRON-	PRP
cord-015021-pol2qm74	949	7	aimed	aim	VBD
cord-015021-pol2qm74	949	8	at	at	IN
cord-015021-pol2qm74	949	9	determining	determine	VBG
cord-015021-pol2qm74	949	10	early	early	JJ
cord-015021-pol2qm74	949	11	alterations	alteration	NNS
cord-015021-pol2qm74	949	12	in	in	IN
cord-015021-pol2qm74	949	13	intestinal	intestinal	JJ
cord-015021-pol2qm74	949	14	transit	transit	NN
cord-015021-pol2qm74	949	15	time	time	NN
cord-015021-pol2qm74	949	16	following	follow	VBG
cord-015021-pol2qm74	949	17	ischemia	ischemia	NN
cord-015021-pol2qm74	949	18	-	-	HYPH
cord-015021-pol2qm74	949	19	reperfusion	reperfusion	NN
cord-015021-pol2qm74	949	20	injury	injury	NN
cord-015021-pol2qm74	949	21	induced	induce	VBN
cord-015021-pol2qm74	949	22	by	by	IN
cord-015021-pol2qm74	949	23	occlusion	occlusion	NN
cord-015021-pol2qm74	949	24	of	of	IN
cord-015021-pol2qm74	949	25	the	the	DT
cord-015021-pol2qm74	949	26	superior	superior	JJ
cord-015021-pol2qm74	949	27	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	949	28	artery	artery	NN
cord-015021-pol2qm74	949	29	in	in	IN
cord-015021-pol2qm74	949	30	the	the	DT
cord-015021-pol2qm74	949	31	rat	rat	NN
cord-015021-pol2qm74	949	32	.	.	.
cord-015021-pol2qm74	950	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	950	2	ischemia	ischemia	NN
cord-015021-pol2qm74	950	3	was	be	VBD
cord-015021-pol2qm74	950	4	induced	induce	VBN
cord-015021-pol2qm74	950	5	for	for	IN
cord-015021-pol2qm74	950	6	20	20	CD
cord-015021-pol2qm74	950	7	and	and	CC
cord-015021-pol2qm74	950	8	30	30	CD
cord-015021-pol2qm74	950	9	minutes	minute	NNS
cord-015021-pol2qm74	950	10	by	by	IN
cord-015021-pol2qm74	950	11	applying	apply	VBG
cord-015021-pol2qm74	950	12	a	a	DT
cord-015021-pol2qm74	950	13	microvascular	microvascular	JJ
cord-015021-pol2qm74	950	14	clip	clip	NN
cord-015021-pol2qm74	950	15	on	on	IN
cord-015021-pol2qm74	950	16	the	the	DT
cord-015021-pol2qm74	950	17	superior	superior	JJ
cord-015021-pol2qm74	950	18	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	950	19	artery	artery	NN
cord-015021-pol2qm74	950	20	followed	follow	VBN
cord-015021-pol2qm74	950	21	by	by	IN
cord-015021-pol2qm74	950	22	reperfusion	reperfusion	NN
cord-015021-pol2qm74	950	23	2	2	CD
cord-015021-pol2qm74	950	24	,	,	,
cord-015021-pol2qm74	950	25	4	4	CD
cord-015021-pol2qm74	950	26	and	and	CC
cord-015021-pol2qm74	950	27	6	6	CD
cord-015021-pol2qm74	950	28	hours	hour	NNS
cord-015021-pol2qm74	950	29	after	after	IN
cord-015021-pol2qm74	950	30	clip	clip	NN
cord-015021-pol2qm74	950	31	removal	removal	NN
cord-015021-pol2qm74	950	32	.	.	.
cord-015021-pol2qm74	951	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	951	2	transit	transit	NN
cord-015021-pol2qm74	951	3	time	time	NN
cord-015021-pol2qm74	951	4	was	be	VBD
cord-015021-pol2qm74	951	5	measured	measure	VBN
cord-015021-pol2qm74	951	6	by	by	IN
cord-015021-pol2qm74	951	7	the	the	DT
cord-015021-pol2qm74	951	8	propulsion	propulsion	NN
cord-015021-pol2qm74	951	9	of	of	IN
cord-015021-pol2qm74	951	10	a	a	DT
cord-015021-pol2qm74	951	11	radiolabelled	radiolabelled	JJ
cord-015021-pol2qm74	951	12	solution	solution	NN
cord-015021-pol2qm74	951	13	(	(	-LRB-
cord-015021-pol2qm74	951	14	Cr51	Cr51	NNP
cord-015021-pol2qm74	951	15	)	)	-RRB-
cord-015021-pol2qm74	951	16	.	.	.
cord-015021-pol2qm74	952	1	Light	light	JJ
cord-015021-pol2qm74	952	2	microscopy	microscopy	NN
cord-015021-pol2qm74	952	3	was	be	VBD
cord-015021-pol2qm74	952	4	performed	perform	VBN
cord-015021-pol2qm74	952	5	on	on	IN
cord-015021-pol2qm74	952	6	intestinal	intestinal	JJ
cord-015021-pol2qm74	952	7	samples	sample	NNS
cord-015021-pol2qm74	952	8	.	.	.
cord-015021-pol2qm74	953	1	Macroscopical	macroscopical	JJ
cord-015021-pol2qm74	953	2	pathological	pathological	JJ
cord-015021-pol2qm74	953	3	changes	change	NNS
cord-015021-pol2qm74	953	4	were	be	VBD
cord-015021-pol2qm74	953	5	not	not	RB
cord-015021-pol2qm74	953	6	observed	observe	VBN
cord-015021-pol2qm74	953	7	.	.	.
cord-015021-pol2qm74	954	1	However	however	RB
cord-015021-pol2qm74	954	2	,	,	,
cord-015021-pol2qm74	954	3	microscopically	microscopically	RB
cord-015021-pol2qm74	954	4	,	,	,
cord-015021-pol2qm74	954	5	mucosal	mucosal	JJ
cord-015021-pol2qm74	954	6	epithelial	epithelial	JJ
cord-015021-pol2qm74	954	7	oedema	oedema	NN
cord-015021-pol2qm74	954	8	,	,	,
cord-015021-pol2qm74	954	9	degeneration	degeneration	NN
cord-015021-pol2qm74	954	10	or	or	CC
cord-015021-pol2qm74	954	11	slight	slight	JJ
cord-015021-pol2qm74	954	12	ulceration	ulceration	NN
cord-015021-pol2qm74	954	13	occurred	occur	VBD
cord-015021-pol2qm74	954	14	in	in	IN
cord-015021-pol2qm74	954	15	rats	rat	NNS
cord-015021-pol2qm74	954	16	6	6	CD
cord-015021-pol2qm74	954	17	hours	hour	NNS
cord-015021-pol2qm74	954	18	after	after	IN
cord-015021-pol2qm74	954	19	reperfusion	reperfusion	NN
cord-015021-pol2qm74	954	20	in	in	IN
cord-015021-pol2qm74	954	21	ischemia-20	ischemia-20	CD
cord-015021-pol2qm74	954	22	rain	rain	NN
cord-015021-pol2qm74	954	23	group	group	NN
cord-015021-pol2qm74	954	24	and	and	CC
cord-015021-pol2qm74	954	25	4	4	CD
cord-015021-pol2qm74	954	26	and	and	CC
cord-015021-pol2qm74	954	27	6	6	CD
cord-015021-pol2qm74	954	28	hours	hour	NNS
cord-015021-pol2qm74	954	29	after	after	IN
cord-015021-pol2qm74	954	30	reperfusion	reperfusion	NN
cord-015021-pol2qm74	954	31	in	in	IN
cord-015021-pol2qm74	954	32	the	the	DT
cord-015021-pol2qm74	954	33	ischemia-40	ischemia-40	NNP
cord-015021-pol2qm74	954	34	rain	rain	NN
cord-015021-pol2qm74	954	35	group	group	NN
cord-015021-pol2qm74	954	36	.	.	.
cord-015021-pol2qm74	955	1	Delayed	delay	VBN
cord-015021-pol2qm74	955	2	small	small	JJ
cord-015021-pol2qm74	955	3	intestinal	intestinal	JJ
cord-015021-pol2qm74	955	4	transit	transit	NN
cord-015021-pol2qm74	955	5	time	time	NN
cord-015021-pol2qm74	955	6	was	be	VBD
cord-015021-pol2qm74	955	7	seen	see	VBN
cord-015021-pol2qm74	955	8	from	from	IN
cord-015021-pol2qm74	955	9	2	2	CD
cord-015021-pol2qm74	955	10	hours	hour	NNS
cord-015021-pol2qm74	955	11	and	and	CC
cord-015021-pol2qm74	955	12	on	on	IN
cord-015021-pol2qm74	955	13	after	after	IN
cord-015021-pol2qm74	955	14	intestinal	intestinal	JJ
cord-015021-pol2qm74	955	15	ischemia	ischemia	NN
cord-015021-pol2qm74	955	16	for	for	IN
cord-015021-pol2qm74	955	17	both	both	DT
cord-015021-pol2qm74	955	18	20	20	CD
cord-015021-pol2qm74	955	19	and	and	CC
cord-015021-pol2qm74	955	20	40	40	CD
cord-015021-pol2qm74	955	21	rain	rain	NN
cord-015021-pol2qm74	955	22	ischemia	ischemia	NN
cord-015021-pol2qm74	955	23	followed	follow	VBN
cord-015021-pol2qm74	955	24	by	by	IN
cord-015021-pol2qm74	955	25	reperfusion	reperfusion	NN
cord-015021-pol2qm74	955	26	.	.	.
cord-015021-pol2qm74	956	1	The	the	DT
cord-015021-pol2qm74	956	2	distribution	distribution	NN
cord-015021-pol2qm74	956	3	of	of	IN
cord-015021-pol2qm74	956	4	radioactivity	radioactivity	NN
cord-015021-pol2qm74	956	5	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	956	6	that	that	IN
cord-015021-pol2qm74	956	7	most	most	JJS
cord-015021-pol2qm74	956	8	radioactivity	radioactivity	NN
cord-015021-pol2qm74	956	9	was	be	VBD
cord-015021-pol2qm74	956	10	accumulated	accumulate	VBN
cord-015021-pol2qm74	956	11	in	in	IN
cord-015021-pol2qm74	956	12	the	the	DT
cord-015021-pol2qm74	956	13	first	first	JJ
cord-015021-pol2qm74	956	14	two	two	CD
cord-015021-pol2qm74	956	15	segments	segment	NNS
cord-015021-pol2qm74	956	16	following	follow	VBG
cord-015021-pol2qm74	956	17	intestinal	intestinal	JJ
cord-015021-pol2qm74	956	18	ischemia	ischemia	NN
cord-015021-pol2qm74	956	19	and	and	CC
cord-015021-pol2qm74	956	20	reperfusion	reperfusion	NN
cord-015021-pol2qm74	956	21	,	,	,
cord-015021-pol2qm74	956	22	significantly	significantly	RB
cord-015021-pol2qm74	956	23	differing	differ	VBG
cord-015021-pol2qm74	956	24	from	from	IN
cord-015021-pol2qm74	956	25	what	what	WP
cord-015021-pol2qm74	956	26	was	be	VBD
cord-015021-pol2qm74	956	27	seen	see	VBN
cord-015021-pol2qm74	956	28	in	in	IN
cord-015021-pol2qm74	956	29	animals	animal	NNS
cord-015021-pol2qm74	956	30	subjected	subject	VBN
cord-015021-pol2qm74	956	31	to	to	IN
cord-015021-pol2qm74	956	32	sham	sham	NN
cord-015021-pol2qm74	956	33	operation	operation	NN
cord-015021-pol2qm74	957	1	(	(	-LRB-
cord-015021-pol2qm74	957	2	p	p	NN
cord-015021-pol2qm74	957	3	<	<	XX
cord-015021-pol2qm74	957	4	0.01	0.01	CD
cord-015021-pol2qm74	957	5	)	)	-RRB-
cord-015021-pol2qm74	957	6	.	.	.
cord-015021-pol2qm74	958	1	The	the	DT
cord-015021-pol2qm74	958	2	distribution	distribution	NN
cord-015021-pol2qm74	958	3	of	of	IN
cord-015021-pol2qm74	958	4	radioactivity	radioactivity	NN
cord-015021-pol2qm74	958	5	in	in	IN
cord-015021-pol2qm74	958	6	segments	segment	NNS
cord-015021-pol2qm74	958	7	4	4	CD
cord-015021-pol2qm74	958	8	and	and	CC
cord-015021-pol2qm74	958	9	5	5	CD
cord-015021-pol2qm74	958	10	in	in	IN
cord-015021-pol2qm74	958	11	the	the	DT
cord-015021-pol2qm74	958	12	group	group	NN
cord-015021-pol2qm74	958	13	with	with	IN
cord-015021-pol2qm74	958	14	repeffusion	repeffusion	NN
cord-015021-pol2qm74	958	15	6	6	CD
cord-015021-pol2qm74	958	16	hours	hour	NNS
cord-015021-pol2qm74	958	17	after	after	IN
cord-015021-pol2qm74	958	18	intestinal	intestinal	JJ
cord-015021-pol2qm74	958	19	iscbemia	iscbemia	NN
cord-015021-pol2qm74	958	20	for	for	IN
cord-015021-pol2qm74	958	21	20	20	CD
cord-015021-pol2qm74	958	22	rain	rain	NN
cord-015021-pol2qm74	958	23	was	be	VBD
cord-015021-pol2qm74	958	24	significantly	significantly	RB
cord-015021-pol2qm74	958	25	higher	high	JJR
cord-015021-pol2qm74	958	26	than	than	IN
cord-015021-pol2qm74	958	27	that	that	DT
cord-015021-pol2qm74	958	28	noted	note	VBD
cord-015021-pol2qm74	958	29	in	in	IN
cord-015021-pol2qm74	958	30	the	the	DT
cord-015021-pol2qm74	958	31	group	group	NN
cord-015021-pol2qm74	958	32	with	with	IN
cord-015021-pol2qm74	958	33	repeffusion	repeffusion	NN
cord-015021-pol2qm74	958	34	6	6	CD
cord-015021-pol2qm74	958	35	hours	hour	NNS
cord-015021-pol2qm74	958	36	after	after	IN
cord-015021-pol2qm74	958	37	intestinal	intestinal	JJ
cord-015021-pol2qm74	958	38	ischemia	ischemia	NN
cord-015021-pol2qm74	958	39	for	for	IN
cord-015021-pol2qm74	958	40	40	40	CD
cord-015021-pol2qm74	958	41	min	min	NN
cord-015021-pol2qm74	958	42	(	(	-LRB-
cord-015021-pol2qm74	958	43	p	p	NN
cord-015021-pol2qm74	958	44	<	<	XX
cord-015021-pol2qm74	958	45	0.01	0.01	CD
cord-015021-pol2qm74	958	46	)	)	-RRB-
cord-015021-pol2qm74	958	47	.	.	.
cord-015021-pol2qm74	959	1	q'he	q'he	NN
cord-015021-pol2qm74	959	2	results	result	NNS
cord-015021-pol2qm74	959	3	indicate	indicate	VBP
cord-015021-pol2qm74	959	4	that	that	IN
cord-015021-pol2qm74	959	5	a	a	DT
cord-015021-pol2qm74	959	6	delayed	delay	VBN
cord-015021-pol2qm74	959	7	intestinal	intestinal	JJ
cord-015021-pol2qm74	959	8	transit	transit	NN
cord-015021-pol2qm74	959	9	time	time	NN
cord-015021-pol2qm74	959	10	may	may	MD
cord-015021-pol2qm74	959	11	be	be	VB
cord-015021-pol2qm74	959	12	one	one	CD
cord-015021-pol2qm74	959	13	of	of	IN
cord-015021-pol2qm74	959	14	the	the	DT
cord-015021-pol2qm74	959	15	earliest	early	JJS
cord-015021-pol2qm74	959	16	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	959	17	alterations	alteration	NNS
cord-015021-pol2qm74	959	18	noted	note	VBN
cord-015021-pol2qm74	959	19	,	,	,
cord-015021-pol2qm74	959	20	associated	associate	VBN
cord-015021-pol2qm74	959	21	with	with	IN
cord-015021-pol2qm74	959	22	duration	duration	NN
cord-015021-pol2qm74	959	23	of	of	IN
cord-015021-pol2qm74	959	24	gut	gut	NN
cord-015021-pol2qm74	959	25	ischemia	ischemia	NN
cord-015021-pol2qm74	959	26	,	,	,
cord-015021-pol2qm74	959	27	and	and	CC
cord-015021-pol2qm74	959	28	a	a	DT
cord-015021-pol2qm74	959	29	potential	potential	JJ
cord-015021-pol2qm74	959	30	factor	factor	NN
cord-015021-pol2qm74	959	31	for	for	IN
cord-015021-pol2qm74	959	32	the	the	DT
cord-015021-pol2qm74	959	33	development	development	NN
cord-015021-pol2qm74	959	34	of	of	IN
cord-015021-pol2qm74	959	35	bacterial	bacterial	JJ
cord-015021-pol2qm74	959	36	overgrowth	overgrowth	NN
cord-015021-pol2qm74	959	37	,	,	,
cord-015021-pol2qm74	959	38	gut	gut	NN
cord-015021-pol2qm74	959	39	barrier	barrier	NN
cord-015021-pol2qm74	959	40	failure	failure	NN
cord-015021-pol2qm74	959	41	and	and	CC
cord-015021-pol2qm74	959	42	bacterial	bacterial	JJ
cord-015021-pol2qm74	959	43	translocation	translocation	NN
cord-015021-pol2qm74	959	44	,	,	,
cord-015021-pol2qm74	959	45	in	in	IN
cord-015021-pol2qm74	959	46	hypovolemic	hypovolemic	JJ
cord-015021-pol2qm74	959	47	conditions	condition	NNS
cord-015021-pol2qm74	959	48	.	.	.
cord-015021-pol2qm74	960	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	960	2	infections	infection	NNS
cord-015021-pol2qm74	960	3	still	still	RB
cord-015021-pol2qm74	960	4	constitute	constitute	VBP
cord-015021-pol2qm74	960	5	a	a	DT
cord-015021-pol2qm74	960	6	major	major	JJ
cord-015021-pol2qm74	960	7	cause	cause	NN
cord-015021-pol2qm74	960	8	of	of	IN
cord-015021-pol2qm74	960	9	morbidity	morbidity	NN
cord-015021-pol2qm74	960	10	and	and	CC
cord-015021-pol2qm74	960	11	mortality	mortality	NN
cord-015021-pol2qm74	960	12	in	in	IN
cord-015021-pol2qm74	960	13	patients	patient	NNS
cord-015021-pol2qm74	960	14	with	with	IN
cord-015021-pol2qm74	960	15	acute	acute	JJ
cord-015021-pol2qm74	960	16	liver	liver	NN
cord-015021-pol2qm74	960	17	failure	failure	NN
cord-015021-pol2qm74	960	18	.	.	.
cord-015021-pol2qm74	961	1	The	the	DT
cord-015021-pol2qm74	961	2	present	present	JJ
cord-015021-pol2qm74	961	3	study	study	NN
cord-015021-pol2qm74	961	4	aimed	aim	VBN
cord-015021-pol2qm74	961	5	at	at	IN
cord-015021-pol2qm74	961	6	evaluating	evaluate	VBG
cord-015021-pol2qm74	961	7	the	the	DT
cord-015021-pol2qm74	961	8	effect	effect	NN
cord-015021-pol2qm74	961	9	of	of	IN
cord-015021-pol2qm74	961	10	ethylhydroxyethyl	ethylhydroxyethyl	NN
cord-015021-pol2qm74	961	11	cellulose	cellulose	NN
cord-015021-pol2qm74	961	12	(	(	-LRB-
cord-015021-pol2qm74	961	13	EHEC	EHEC	NNP
cord-015021-pol2qm74	961	14	)	)	-RRB-
cord-015021-pol2qm74	961	15	on	on	IN
cord-015021-pol2qm74	961	16	bacterial	bacterial	JJ
cord-015021-pol2qm74	961	17	translocation	translocation	NN
cord-015021-pol2qm74	961	18	following	follow	VBG
cord-015021-pol2qm74	961	19	surgically	surgically	RB
cord-015021-pol2qm74	961	20	induced	induce	VBN
cord-015021-pol2qm74	961	21	acute	acute	JJ
cord-015021-pol2qm74	961	22	liver	liver	NN
cord-015021-pol2qm74	961	23	failure	failure	NN
cord-015021-pol2qm74	961	24	.	.	.
cord-015021-pol2qm74	962	1	Acute	acute	JJ
cord-015021-pol2qm74	962	2	liver	liver	NN
cord-015021-pol2qm74	962	3	failure	failure	NN
cord-015021-pol2qm74	962	4	was	be	VBD
cord-015021-pol2qm74	962	5	induced	induce	VBN
cord-015021-pol2qm74	962	6	by	by	IN
cord-015021-pol2qm74	962	7	subtotal	subtotal	NN
cord-015021-pol2qm74	962	8	hepatectomy	hepatectomy	NNP
cord-015021-pol2qm74	962	9	(	(	-LRB-
cord-015021-pol2qm74	962	10	90	90	CD
cord-015021-pol2qm74	962	11	%	%	NN
cord-015021-pol2qm74	962	12	)	)	-RRB-
cord-015021-pol2qm74	962	13	in	in	IN
cord-015021-pol2qm74	962	14	the	the	DT
cord-015021-pol2qm74	962	15	rat	rat	NN
cord-015021-pol2qm74	962	16	.	.	.
cord-015021-pol2qm74	963	1	Water	water	NN
cord-015021-pol2qm74	963	2	-	-	HYPH
cord-015021-pol2qm74	963	3	soluble	soluble	JJ
cord-015021-pol2qm74	963	4	EHEC	EHEC	NNP
cord-015021-pol2qm74	963	5	was	be	VBD
cord-015021-pol2qm74	963	6	administered	administer	VBN
cord-015021-pol2qm74	963	7	orally	orally	RB
cord-015021-pol2qm74	963	8	1	1	CD
cord-015021-pol2qm74	963	9	and	and	CC
cord-015021-pol2qm74	963	10	12	12	CD
cord-015021-pol2qm74	963	11	hours	hour	NNS
cord-015021-pol2qm74	963	12	prior	prior	RB
cord-015021-pol2qm74	963	13	to	to	IN
cord-015021-pol2qm74	963	14	hepatectomy	hepatectomy	NNP
cord-015021-pol2qm74	963	15	.	.	.
cord-015021-pol2qm74	964	1	The	the	DT
cord-015021-pol2qm74	964	2	incidence	incidence	NN
cord-015021-pol2qm74	964	3	of	of	IN
cord-015021-pol2qm74	964	4	bacterial	bacterial	JJ
cord-015021-pol2qm74	964	5	translocation	translocation	NN
cord-015021-pol2qm74	964	6	from	from	IN
cord-015021-pol2qm74	964	7	the	the	DT
cord-015021-pol2qm74	964	8	gut	gut	NN
cord-015021-pol2qm74	964	9	to	to	IN
cord-015021-pol2qm74	964	10	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	964	11	lymph	lymph	NN
cord-015021-pol2qm74	964	12	nodes	node	NNS
cord-015021-pol2qm74	964	13	(	(	-LRB-
cord-015021-pol2qm74	964	14	MLNs	MLNs	NNP
cord-015021-pol2qm74	964	15	)	)	-RRB-
cord-015021-pol2qm74	964	16	and	and	CC
cord-015021-pol2qm74	964	17	systemic	systemic	JJ
cord-015021-pol2qm74	964	18	and	and	CC
cord-015021-pol2qm74	964	19	portal	portal	JJ
cord-015021-pol2qm74	964	20	circulation	circulation	NN
cord-015021-pol2qm74	964	21	was	be	VBD
cord-015021-pol2qm74	964	22	evaluated	evaluate	VBN
cord-015021-pol2qm74	964	23	and	and	CC
cord-015021-pol2qm74	964	24	the	the	DT
cord-015021-pol2qm74	964	25	number	number	NN
cord-015021-pol2qm74	964	26	of	of	IN
cord-015021-pol2qm74	964	27	isolated	isolate	VBN
cord-015021-pol2qm74	964	28	bacteria	bacteria	NNS
cord-015021-pol2qm74	964	29	from	from	IN
cord-015021-pol2qm74	964	30	these	these	DT
cord-015021-pol2qm74	964	31	samples	sample	NNS
cord-015021-pol2qm74	964	32	and	and	CC
cord-015021-pol2qm74	964	33	from	from	IN
cord-015021-pol2qm74	964	34	intestinal	intestinal	JJ
cord-015021-pol2qm74	964	35	content	content	NN
cord-015021-pol2qm74	964	36	were	be	VBD
cord-015021-pol2qm74	964	37	determined	determine	VBN
cord-015021-pol2qm74	964	38	.	.	.
cord-015021-pol2qm74	965	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	965	2	transit	transit	NN
cord-015021-pol2qm74	965	3	time	time	NN
cord-015021-pol2qm74	965	4	,	,	,
cord-015021-pol2qm74	965	5	bacterial	bacterial	JJ
cord-015021-pol2qm74	965	6	adherence	adherence	NN
cord-015021-pol2qm74	965	7	onto	onto	IN
cord-015021-pol2qm74	965	8	the	the	DT
cord-015021-pol2qm74	965	9	intestinal	intestinal	JJ
cord-015021-pol2qm74	965	10	surface	surface	NN
cord-015021-pol2qm74	965	11	,	,	,
cord-015021-pol2qm74	965	12	intestinal	intestinal	JJ
cord-015021-pol2qm74	965	13	mucosal	mucosal	JJ
cord-015021-pol2qm74	965	14	mass	mass	NN
cord-015021-pol2qm74	965	15	,	,	,
cord-015021-pol2qm74	965	16	bacterial	bacterial	JJ
cord-015021-pol2qm74	965	17	growth	growth	NN
cord-015021-pol2qm74	965	18	and	and	CC
cord-015021-pol2qm74	965	19	DNA	dna	NN
cord-015021-pol2qm74	965	20	synthesis	synthesis	NN
cord-015021-pol2qm74	965	21	,	,	,
cord-015021-pol2qm74	965	22	bacterial	bacterial	JJ
cord-015021-pol2qm74	965	23	surface	surface	NN
cord-015021-pol2qm74	965	24	characteristics	characteristic	NNS
cord-015021-pol2qm74	965	25	(	(	-LRB-
cord-015021-pol2qm74	965	26	hydrobiology	hydrobiology	NN
cord-015021-pol2qm74	965	27	:	:	:
cord-015021-pol2qm74	965	28	hydrophobicity	hydrophobicity	NN
cord-015021-pol2qm74	965	29	,	,	,
cord-015021-pol2qm74	965	30	hydrophilicity	hydrophilicity	NN
cord-015021-pol2qm74	965	31	and	and	CC
cord-015021-pol2qm74	965	32	neutrality	neutrality	NN
cord-015021-pol2qm74	965	33	;	;	:
cord-015021-pol2qm74	965	34	surface	surface	NN
cord-015021-pol2qm74	965	35	charges	charge	NNS
cord-015021-pol2qm74	965	36	:	:	:
cord-015021-pol2qm74	965	37	positive	positive	JJ
cord-015021-pol2qm74	965	38	,	,	,
cord-015021-pol2qm74	965	39	negative	negative	JJ
cord-015021-pol2qm74	965	40	and	and	CC
cord-015021-pol2qm74	965	41	neutral	neutral	JJ
cord-015021-pol2qm74	965	42	)	)	-RRB-
cord-015021-pol2qm74	965	43	were	be	VBD
cord-015021-pol2qm74	965	44	also	also	RB
cord-015021-pol2qm74	965	45	determined	determine	VBN
cord-015021-pol2qm74	965	46	.	.	.
cord-015021-pol2qm74	966	1	Hepatectomized	hepatectomized	JJ
cord-015021-pol2qm74	966	2	animals	animal	NNS
cord-015021-pol2qm74	966	3	showed	show	VBD
cord-015021-pol2qm74	966	4	a	a	DT
cord-015021-pol2qm74	966	5	80	80	CD
cord-015021-pol2qm74	966	6	-	-	SYM
cord-015021-pol2qm74	966	7	100	100	CD
cord-015021-pol2qm74	966	8	%	%	NN
cord-015021-pol2qm74	966	9	translocation	translocation	NN
cord-015021-pol2qm74	966	10	rate	rate	NN
cord-015021-pol2qm74	966	11	to	to	IN
cord-015021-pol2qm74	966	12	MLNs	mln	NNS
cord-015021-pol2qm74	966	13	or	or	CC
cord-015021-pol2qm74	966	14	blood	blood	NN
cord-015021-pol2qm74	966	15	2	2	CD
cord-015021-pol2qm74	966	16	and	and	CC
cord-015021-pol2qm74	966	17	4	4	CD
cord-015021-pol2qm74	966	18	hours	hour	NNS
cord-015021-pol2qm74	966	19	after	after	IN
cord-015021-pol2qm74	966	20	operation	operation	NN
cord-015021-pol2qm74	966	21	,	,	,
cord-015021-pol2qm74	966	22	while	while	IN
cord-015021-pol2qm74	966	23	only	only	RB
cord-015021-pol2qm74	966	24	0	0	CD
cord-015021-pol2qm74	966	25	-	-	SYM
cord-015021-pol2qm74	966	26	1	1	CD
cord-015021-pol2qm74	966	27	%	%	NN
cord-015021-pol2qm74	966	28	of	of	IN
cord-015021-pol2qm74	966	29	rats	rat	NNS
cord-015021-pol2qm74	966	30	subjected	subject	VBN
cord-015021-pol2qm74	966	31	to	to	IN
cord-015021-pol2qm74	966	32	sham	sham	JJ
cord-015021-pol2qm74	966	33	operation	operation	NN
cord-015021-pol2qm74	966	34	or	or	CC
cord-015021-pol2qm74	966	35	animals	animal	NNS
cord-015021-pol2qm74	966	36	with	with	IN
cord-015021-pol2qm74	966	37	90	90	CD
cord-015021-pol2qm74	966	38	%	%	NN
cord-015021-pol2qm74	966	39	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	966	40	and	and	CC
cord-015021-pol2qm74	966	41	pre	pre	JJ
cord-015021-pol2qm74	966	42	-	-	NN
cord-015021-pol2qm74	966	43	treatment	treatment	NN
cord-015021-pol2qm74	966	44	with	with	IN
cord-015021-pol2qm74	966	45	EHEC	EHEC	NNP
cord-015021-pol2qm74	966	46	(	(	-LRB-
cord-015021-pol2qm74	966	47	p	p	NN
cord-015021-pol2qm74	966	48	<	<	XX
cord-015021-pol2qm74	966	49	0.01	0.01	CD
cord-015021-pol2qm74	966	50	)	)	-RRB-
cord-015021-pol2qm74	966	51	.	.	.
cord-015021-pol2qm74	967	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	967	2	overgrowth	overgrowth	NN
cord-015021-pol2qm74	967	3	,	,	,
cord-015021-pol2qm74	967	4	increased	increase	VBN
cord-015021-pol2qm74	967	5	bacterial	bacterial	JJ
cord-015021-pol2qm74	967	6	adherence	adherence	NN
cord-015021-pol2qm74	967	7	onto	onto	IN
cord-015021-pol2qm74	967	8	the	the	DT
cord-015021-pol2qm74	967	9	intestinal	intestinal	JJ
cord-015021-pol2qm74	967	10	surface	surface	NN
cord-015021-pol2qm74	967	11	as	as	RB
cord-015021-pol2qm74	967	12	well	well	RB
cord-015021-pol2qm74	967	13	as	as	IN
cord-015021-pol2qm74	967	14	decreased	decrease	VBN
cord-015021-pol2qm74	967	15	intestinal	intestinal	JJ
cord-015021-pol2qm74	967	16	mucosal	mucosal	JJ
cord-015021-pol2qm74	967	17	masses	masse	NNS
cord-015021-pol2qm74	967	18	were	be	VBD
cord-015021-pol2qm74	967	19	observed	observe	VBN
cord-015021-pol2qm74	967	20	in	in	IN
cord-015021-pol2qm74	967	21	animals	animal	NNS
cord-015021-pol2qm74	967	22	with	with	IN
cord-015021-pol2qm74	967	23	subtotal	subtotal	NN
cord-015021-pol2qm74	967	24	liver	liver	NN
cord-015021-pol2qm74	967	25	resection	resection	NN
cord-015021-pol2qm74	967	26	alone	alone	RB
cord-015021-pol2qm74	967	27	,	,	,
cord-015021-pol2qm74	967	28	alterations	alteration	NNS
cord-015021-pol2qm74	967	29	that	that	WDT
cord-015021-pol2qm74	967	30	were	be	VBD
cord-015021-pol2qm74	967	31	prevented	prevent	VBN
cord-015021-pol2qm74	967	32	by	by	IN
cord-015021-pol2qm74	967	33	enteral	enteral	JJ
cord-015021-pol2qm74	967	34	EHEC	EHEC	NNP
cord-015021-pol2qm74	967	35	treatment	treatment	NN
cord-015021-pol2qm74	967	36	.	.	.
cord-015021-pol2qm74	968	1	A	a	DT
cord-015021-pol2qm74	968	2	delay	delay	NN
cord-015021-pol2qm74	968	3	in	in	IN
cord-015021-pol2qm74	968	4	intestinal	intestinal	JJ
cord-015021-pol2qm74	968	5	2-hour	2-hour	CD
cord-015021-pol2qm74	968	6	transit	transit	NN
cord-015021-pol2qm74	968	7	time	time	NN
cord-015021-pol2qm74	968	8	occurred	occur	VBD
cord-015021-pol2qm74	968	9	in	in	IN
cord-015021-pol2qm74	968	10	both	both	DT
cord-015021-pol2qm74	968	11	groups	group	NNS
cord-015021-pol2qm74	968	12	with	with	IN
cord-015021-pol2qm74	968	13	subtotal	subtotal	NN
cord-015021-pol2qm74	968	14	liver	liver	NN
cord-015021-pol2qm74	968	15	resection	resection	NN
cord-015021-pol2qm74	968	16	,	,	,
cord-015021-pol2qm74	968	17	with	with	IN
cord-015021-pol2qm74	968	18	or	or	CC
cord-015021-pol2qm74	968	19	without	without	IN
cord-015021-pol2qm74	968	20	enteral	enteral	JJ
cord-015021-pol2qm74	968	21	EHEC	EHEC	NNP
cord-015021-pol2qm74	968	22	.	.	.
cord-015021-pol2qm74	969	1	EHEC	EHEC	NNP
cord-015021-pol2qm74	969	2	inhibited	inhibit	VBD
cord-015021-pol2qm74	969	3	bacterial	bacterial	JJ
cord-015021-pol2qm74	969	4	growth	growth	NN
cord-015021-pol2qm74	969	5	and	and	CC
cord-015021-pol2qm74	969	6	DNA	dna	NN
cord-015021-pol2qm74	969	7	synthesis	synthesis	NN
cord-015021-pol2qm74	969	8	,	,	,
cord-015021-pol2qm74	969	9	and	and	CC
cord-015021-pol2qm74	969	10	altered	alter	VBN
cord-015021-pol2qm74	969	11	bacterial	bacterial	JJ
cord-015021-pol2qm74	969	12	surface	surface	NN
cord-015021-pol2qm74	969	13	properties	property	NNS
cord-015021-pol2qm74	969	14	following	follow	VBG
cord-015021-pol2qm74	969	15	1hour	1hour	CD
cord-015021-pol2qm74	969	16	incubation	incubation	NN
cord-015021-pol2qm74	969	17	with	with	IN
cord-015021-pol2qm74	969	18	bacteria	bacteria	NNS
cord-015021-pol2qm74	969	19	.	.	.
cord-015021-pol2qm74	970	1	In	in	IN
cord-015021-pol2qm74	970	2	conclusion	conclusion	NN
cord-015021-pol2qm74	970	3	,	,	,
cord-015021-pol2qm74	970	4	the	the	DT
cord-015021-pol2qm74	970	5	findings	finding	NNS
cord-015021-pol2qm74	970	6	in	in	IN
cord-015021-pol2qm74	970	7	the	the	DT
cord-015021-pol2qm74	970	8	present	present	JJ
cord-015021-pol2qm74	970	9	study	study	NN
cord-015021-pol2qm74	970	10	imply	imply	VBP
cord-015021-pol2qm74	970	11	that	that	IN
cord-015021-pol2qm74	970	12	EHEC	EHEC	NNP
cord-015021-pol2qm74	970	13	alters	alter	VBZ
cord-015021-pol2qm74	970	14	enterobacterial	enterobacterial	JJ
cord-015021-pol2qm74	970	15	capacities	capacity	NNS
cord-015021-pol2qm74	970	16	for	for	IN
cord-015021-pol2qm74	970	17	metabolism	metabolism	NN
cord-015021-pol2qm74	970	18	,	,	,
cord-015021-pol2qm74	970	19	proliferation	proliferation	NN
cord-015021-pol2qm74	970	20	and	and	CC
cord-015021-pol2qm74	970	21	invasion	invasion	NN
cord-015021-pol2qm74	970	22	by	by	IN
cord-015021-pol2qm74	970	23	effects	effect	NNS
cord-015021-pol2qm74	970	24	on	on	IN
cord-015021-pol2qm74	970	25	e.g.	e.g.	JJ
cord-015021-pol2qm74	970	26	bacterial	bacterial	JJ
cord-015021-pol2qm74	970	27	surface	surface	NN
cord-015021-pol2qm74	970	28	characteristics	characteristic	NNS
cord-015021-pol2qm74	970	29	.	.	.
cord-015021-pol2qm74	971	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	971	2	,	,	,
cord-015021-pol2qm74	971	3	EHEC	EHEC	NNP
cord-015021-pol2qm74	971	4	seems	seem	VBZ
cord-015021-pol2qm74	971	5	to	to	TO
cord-015021-pol2qm74	971	6	possess	possess	VB
cord-015021-pol2qm74	971	7	a	a	DT
cord-015021-pol2qm74	971	8	trophic	trophic	JJ
cord-015021-pol2qm74	971	9	action	action	NN
cord-015021-pol2qm74	971	10	on	on	IN
cord-015021-pol2qm74	971	11	the	the	DT
cord-015021-pol2qm74	971	12	intestine	intestine	NN
cord-015021-pol2qm74	971	13	,	,	,
cord-015021-pol2qm74	971	14	rather	rather	RB
cord-015021-pol2qm74	971	15	than	than	IN
cord-015021-pol2qm74	971	16	exerting	exert	VBG
cord-015021-pol2qm74	971	17	its	-PRON-	PRP$
cord-015021-pol2qm74	971	18	effect	effect	NN
cord-015021-pol2qm74	971	19	by	by	IN
cord-015021-pol2qm74	971	20	enhancing	enhance	VBG
cord-015021-pol2qm74	971	21	intestinal	intestinal	JJ
cord-015021-pol2qm74	971	22	motility	motility	NN
cord-015021-pol2qm74	971	23	.	.	.
cord-015021-pol2qm74	972	1	Department	Department	NNP
cord-015021-pol2qm74	972	2	of	of	IN
cord-015021-pol2qm74	972	3	Surgery	Surgery	NNP
cord-015021-pol2qm74	972	4	,	,	,
cord-015021-pol2qm74	972	5	Lund	Lund	NNP
cord-015021-pol2qm74	972	6	University	University	NNP
cord-015021-pol2qm74	972	7	Hospital	Hospital	NNP
cord-015021-pol2qm74	972	8	,	,	,
cord-015021-pol2qm74	972	9	S-221	s-221	NN
cord-015021-pol2qm74	972	10	85	85	CD
cord-015021-pol2qm74	972	11	Lund	Lund	NNP
cord-015021-pol2qm74	972	12	,	,	,
cord-015021-pol2qm74	972	13	Sweden	Sweden	NNP
cord-015021-pol2qm74	972	14	Disturbances	Disturbances	NNPS
cord-015021-pol2qm74	972	15	in	in	IN
cord-015021-pol2qm74	972	16	intracellular	intracellular	JJ
cord-015021-pol2qm74	972	17	calcium	calcium	NN
cord-015021-pol2qm74	972	18	signalling	signalling	NN
cord-015021-pol2qm74	972	19	can	can	MD
cord-015021-pol2qm74	972	20	potentially	potentially	RB
cord-015021-pol2qm74	972	21	result	result	VB
cord-015021-pol2qm74	972	22	in	in	IN
cord-015021-pol2qm74	972	23	impairments	impairment	NNS
cord-015021-pol2qm74	972	24	of	of	IN
cord-015021-pol2qm74	972	25	cellular	cellular	JJ
cord-015021-pol2qm74	972	26	responses	response	NNS
cord-015021-pol2qm74	972	27	vital	vital	JJ
cord-015021-pol2qm74	972	28	to	to	IN
cord-015021-pol2qm74	972	29	the	the	DT
cord-015021-pol2qm74	972	30	functional	functional	JJ
cord-015021-pol2qm74	972	31	integrity	integrity	NN
cord-015021-pol2qm74	972	32	of	of	IN
cord-015021-pol2qm74	972	33	both	both	DT
cord-015021-pol2qm74	972	34	immune	immune	JJ
cord-015021-pol2qm74	972	35	and	and	CC
cord-015021-pol2qm74	972	36	non	non	JJ
cord-015021-pol2qm74	972	37	-	-	JJ
cord-015021-pol2qm74	972	38	immune	immune	JJ
cord-015021-pol2qm74	972	39	cells	cell	NNS
cord-015021-pol2qm74	972	40	,	,	,
cord-015021-pol2qm74	972	41	and	and	CC
cord-015021-pol2qm74	972	42	thus	thus	RB
cord-015021-pol2qm74	972	43	contribute	contribute	VB
cord-015021-pol2qm74	972	44	to	to	IN
cord-015021-pol2qm74	972	45	a	a	DT
cord-015021-pol2qm74	972	46	decrease	decrease	NN
cord-015021-pol2qm74	972	47	in	in	IN
cord-015021-pol2qm74	972	48	host	host	NN
cord-015021-pol2qm74	972	49	resistance	resistance	NN
cord-015021-pol2qm74	972	50	against	against	IN
cord-015021-pol2qm74	972	51	infection	infection	NN
cord-015021-pol2qm74	972	52	and	and	CC
cord-015021-pol2qm74	972	53	to	to	IN
cord-015021-pol2qm74	972	54	multiple	multiple	JJ
cord-015021-pol2qm74	972	55	organ	organ	NN
cord-015021-pol2qm74	972	56	system	system	NN
cord-015021-pol2qm74	972	57	failure	failure	NN
cord-015021-pol2qm74	972	58	during	during	IN
cord-015021-pol2qm74	972	59	sepsis	sepsis	NN
cord-015021-pol2qm74	972	60	.	.	.
cord-015021-pol2qm74	973	1	Studies	study	NNS
cord-015021-pol2qm74	973	2	in	in	IN
cord-015021-pol2qm74	973	3	our	-PRON-	PRP$
cord-015021-pol2qm74	973	4	laboratory	laboratory	NN
cord-015021-pol2qm74	973	5	have	have	VBP
cord-015021-pol2qm74	973	6	focused	focus	VBN
cord-015021-pol2qm74	973	7	on	on	IN
cord-015021-pol2qm74	973	8	assessments	assessment	NNS
cord-015021-pol2qm74	973	9	of	of	IN
cord-015021-pol2qm74	973	10	intracellular	intracellular	JJ
cord-015021-pol2qm74	973	11	Ca	Ca	NNP
cord-015021-pol2qm74	973	12	2÷	2÷	CD
cord-015021-pol2qm74	973	13	regulation	regulation	NN
cord-015021-pol2qm74	973	14	and	and	CC
cord-015021-pol2qm74	973	15	Ca~+-depended	Ca~+-depended	NNP
cord-015021-pol2qm74	973	16	cellular	cellular	JJ
cord-015021-pol2qm74	973	17	responses	response	NNS
cord-015021-pol2qm74	973	18	in	in	IN
cord-015021-pol2qm74	973	19	the	the	DT
cord-015021-pol2qm74	973	20	liver	liver	NN
cord-015021-pol2qm74	973	21	,	,	,
cord-015021-pol2qm74	973	22	skeletal	skeletal	JJ
cord-015021-pol2qm74	973	23	muscle	muscle	NN
cord-015021-pol2qm74	973	24	and	and	CC
cord-015021-pol2qm74	973	25	splenic	splenic	JJ
cord-015021-pol2qm74	973	26	Tlymphocytes	Tlymphocytes	NNPS
cord-015021-pol2qm74	973	27	harvested	harvest	VBN
cord-015021-pol2qm74	973	28	from	from	IN
cord-015021-pol2qm74	973	29	rats	rat	NNS
cord-015021-pol2qm74	973	30	subjected	subject	VBN
cord-015021-pol2qm74	973	31	to	to	IN
cord-015021-pol2qm74	973	32	gram	gram	NN
cord-015021-pol2qm74	973	33	-	-	HYPH
cord-015021-pol2qm74	973	34	negative	negative	JJ
cord-015021-pol2qm74	973	35	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	973	36	sepsis	sepsis	NN
cord-015021-pol2qm74	973	37	.	.	.
cord-015021-pol2qm74	974	1	Cytosolic	Cytosolic	NNP
cord-015021-pol2qm74	975	1	Ca	ca	NN
cord-015021-pol2qm74	975	2	2	2	CD
cord-015021-pol2qm74	975	3	+	+	CC
cord-015021-pol2qm74	975	4	concentration	concentration	NN
cord-015021-pol2qm74	975	5	,	,	,
cord-015021-pol2qm74	975	6	[	[	-LRB-
cord-015021-pol2qm74	975	7	Ca2*]i	Ca2*]i	NNP
cord-015021-pol2qm74	975	8	,	,	,
cord-015021-pol2qm74	975	9	and	and	CC
cord-015021-pol2qm74	976	1	Ca	ca	NN
cord-015021-pol2qm74	976	2	2	2	CD
cord-015021-pol2qm74	976	3	+	+	CD
cord-015021-pol2qm74	976	4	fluxes	flux	NNS
cord-015021-pol2qm74	976	5	were	be	VBD
cord-015021-pol2qm74	976	6	measured	measure	VBN
cord-015021-pol2qm74	976	7	by	by	IN
cord-015021-pol2qm74	976	8	the	the	DT
cord-015021-pol2qm74	976	9	use	use	NN
cord-015021-pol2qm74	976	10	of	of	IN
cord-015021-pol2qm74	976	11	fluorescent	fluorescent	NN
cord-015021-pol2qm74	977	1	Ca	ca	NN
cord-015021-pol2qm74	977	2	2	2	CD
cord-015021-pol2qm74	977	3	+	+	SYM
cord-015021-pol2qm74	977	4	chelating	chelating	NN
cord-015021-pol2qm74	977	5	dyes	dye	NNS
cord-015021-pol2qm74	977	6	(	(	-LRB-
cord-015021-pol2qm74	977	7	Fura-2	Fura-2	NNP
cord-015021-pol2qm74	977	8	or	or	CC
cord-015021-pol2qm74	977	9	indo-1	indo-1	NNP
cord-015021-pol2qm74	977	10	)	)	-RRB-
cord-015021-pol2qm74	977	11	and	and	CC
cord-015021-pol2qm74	977	12	45	45	CD
cord-015021-pol2qm74	977	13	Ca	Ca	MD
cord-015021-pol2qm74	977	14	respectively	respectively	RB
cord-015021-pol2qm74	977	15	.	.	.
cord-015021-pol2qm74	978	1	To	to	TO
cord-015021-pol2qm74	978	2	assess	assess	VB
cord-015021-pol2qm74	978	3	sepsis	sepsis	NN
cord-015021-pol2qm74	978	4	-	-	HYPH
cord-015021-pol2qm74	978	5	related	relate	VBN
cord-015021-pol2qm74	978	6	changes	change	NNS
cord-015021-pol2qm74	978	7	in	in	IN
cord-015021-pol2qm74	978	8	Ca	Ca	NNP
cord-015021-pol2qm74	978	9	2	2	CD
cord-015021-pol2qm74	978	10	+	+	CC
cord-015021-pol2qm74	978	11	dependent	dependent	JJ
cord-015021-pol2qm74	978	12	cellular	cellular	JJ
cord-015021-pol2qm74	978	13	responses	response	NNS
cord-015021-pol2qm74	978	14	,	,	,
cord-015021-pol2qm74	978	15	we	-PRON-	PRP
cord-015021-pol2qm74	978	16	measured	measure	VBD
cord-015021-pol2qm74	978	17	the	the	DT
cord-015021-pol2qm74	978	18	acute	acute	JJ
cord-015021-pol2qm74	978	19	phase	phase	NN
cord-015021-pol2qm74	978	20	protein	protein	NN
cord-015021-pol2qm74	978	21	response	response	NN
cord-015021-pol2qm74	978	22	in	in	IN
cord-015021-pol2qm74	978	23	the	the	DT
cord-015021-pol2qm74	978	24	liver	liver	NN
cord-015021-pol2qm74	978	25	,	,	,
cord-015021-pol2qm74	978	26	the	the	DT
cord-015021-pol2qm74	978	27	regulation	regulation	NN
cord-015021-pol2qm74	978	28	of	of	IN
cord-015021-pol2qm74	978	29	protein	protein	NN
cord-015021-pol2qm74	978	30	and	and	CC
cord-015021-pol2qm74	978	31	sugar	sugar	NN
cord-015021-pol2qm74	978	32	metabolism	metabolism	NN
cord-015021-pol2qm74	978	33	in	in	IN
cord-015021-pol2qm74	978	34	the	the	DT
cord-015021-pol2qm74	978	35	skeletal	skeletal	JJ
cord-015021-pol2qm74	978	36	muscle	muscle	NN
cord-015021-pol2qm74	978	37	,	,	,
cord-015021-pol2qm74	978	38	and	and	CC
cord-015021-pol2qm74	978	39	the	the	DT
cord-015021-pol2qm74	978	40	proliferation	proliferation	NN
cord-015021-pol2qm74	978	41	response	response	NN
cord-015021-pol2qm74	978	42	in	in	IN
cord-015021-pol2qm74	978	43	the	the	DT
cord-015021-pol2qm74	978	44	splenic	splenic	JJ
cord-015021-pol2qm74	978	45	Tlymphocytes	Tlymphocytes	NNPS
cord-015021-pol2qm74	978	46	.	.	.
cord-015021-pol2qm74	979	1	Altered	alter	VBN
cord-015021-pol2qm74	979	2	Ca2	ca2	CD
cord-015021-pol2qm74	980	1	+	+	CC
cord-015021-pol2qm74	981	1	i	i	PRP
cord-015021-pol2qm74	981	2	signalling	signal	VBG
cord-015021-pol2qm74	981	3	with	with	IN
cord-015021-pol2qm74	981	4	sepsis	sepsis	NN
cord-015021-pol2qm74	981	5	was	be	VBD
cord-015021-pol2qm74	981	6	correlated	correlate	VBN
cord-015021-pol2qm74	981	7	with	with	IN
cord-015021-pol2qm74	981	8	an	an	DT
cord-015021-pol2qm74	981	9	exaggerated	exaggerated	JJ
cord-015021-pol2qm74	981	10	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	981	11	acute	acute	JJ
cord-015021-pol2qm74	981	12	phase	phase	NN
cord-015021-pol2qm74	981	13	protein	protein	NN
cord-015021-pol2qm74	981	14	response	response	NN
cord-015021-pol2qm74	981	15	(	(	-LRB-
cord-015021-pol2qm74	981	16	100	100	CD
cord-015021-pol2qm74	981	17	%	%	NN
cord-015021-pol2qm74	981	18	¢	¢	NNP
cord-015021-pol2qm74	981	19	)	)	-RRB-
cord-015021-pol2qm74	981	20	in	in	IN
cord-015021-pol2qm74	981	21	the	the	DT
cord-015021-pol2qm74	981	22	liver	liver	NN
cord-015021-pol2qm74	981	23	,	,	,
cord-015021-pol2qm74	981	24	and	and	CC
cord-015021-pol2qm74	981	25	a	a	DT
cord-015021-pol2qm74	981	26	blunted	blunt	VBN
cord-015021-pol2qm74	981	27	insulin	insulin	NN
cord-015021-pol2qm74	981	28	mediated	mediate	VBN
cord-015021-pol2qm74	981	29	sugar	sugar	NN
cord-015021-pol2qm74	981	30	utilization	utilization	NN
cord-015021-pol2qm74	981	31	(	(	-LRB-
cord-015021-pol2qm74	981	32	60	60	CD
cord-015021-pol2qm74	981	33	%	%	NN
cord-015021-pol2qm74	981	34	4	4	CD
cord-015021-pol2qm74	981	35	)	)	-RRB-
cord-015021-pol2qm74	981	36	and	and	CC
cord-015021-pol2qm74	981	37	increased	increase	VBN
cord-015021-pol2qm74	981	38	proteolysis	proteolysis	NN
cord-015021-pol2qm74	981	39	(	(	-LRB-
cord-015021-pol2qm74	981	40	50	50	CD
cord-015021-pol2qm74	981	41	%	%	NN
cord-015021-pol2qm74	981	42	~	~	CD
cord-015021-pol2qm74	981	43	)	)	-RRB-
cord-015021-pol2qm74	981	44	in	in	IN
cord-015021-pol2qm74	981	45	the	the	DT
cord-015021-pol2qm74	981	46	skeletal	skeletal	JJ
cord-015021-pol2qm74	981	47	muscle	muscle	NN
cord-015021-pol2qm74	981	48	.	.	.
cord-015021-pol2qm74	982	1	In	in	IN
cord-015021-pol2qm74	982	2	T	t	NN
cord-015021-pol2qm74	982	3	-	-	HYPH
cord-015021-pol2qm74	982	4	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	982	5	,	,	,
cord-015021-pol2qm74	982	6	a	a	DT
cord-015021-pol2qm74	982	7	decrease	decrease	NN
cord-015021-pol2qm74	982	8	in	in	IN
cord-015021-pol2qm74	982	9	mitogen	mitogen	NNP
cord-015021-pol2qm74	982	10	induced	induce	VBN
cord-015021-pol2qm74	982	11	elevation	elevation	NN
cord-015021-pol2qm74	982	12	of	of	IN
cord-015021-pol2qm74	982	13	[	[	-LRB-
cord-015021-pol2qm74	982	14	Ca2+]i	Ca2+]i	NNP
cord-015021-pol2qm74	982	15	by	by	IN
cord-015021-pol2qm74	982	16	35	35	CD
cord-015021-pol2qm74	982	17	-	-	SYM
cord-015021-pol2qm74	982	18	40	40	CD
cord-015021-pol2qm74	982	19	%	%	NN
cord-015021-pol2qm74	982	20	was	be	VBD
cord-015021-pol2qm74	982	21	correlated	correlate	VBN
cord-015021-pol2qm74	982	22	with	with	IN
cord-015021-pol2qm74	982	23	a	a	DT
cord-015021-pol2qm74	982	24	significant	significant	JJ
cord-015021-pol2qm74	982	25	depression	depression	NN
cord-015021-pol2qm74	982	26	in	in	IN
cord-015021-pol2qm74	982	27	their	-PRON-	PRP$
cord-015021-pol2qm74	982	28	proliferative	proliferative	JJ
cord-015021-pol2qm74	982	29	capacity	capacity	NN
cord-015021-pol2qm74	982	30	.	.	.
cord-015021-pol2qm74	983	1	These	these	DT
cord-015021-pol2qm74	983	2	studies	study	NNS
cord-015021-pol2qm74	983	3	clearly	clearly	RB
cord-015021-pol2qm74	983	4	suggest	suggest	VBP
cord-015021-pol2qm74	983	5	that	that	IN
cord-015021-pol2qm74	983	6	altered	alter	VBN
cord-015021-pol2qm74	983	7	calcium	calcium	NN
cord-015021-pol2qm74	983	8	signalling	signalling	NN
cord-015021-pol2qm74	983	9	is	be	VBZ
cord-015021-pol2qm74	983	10	correlated	correlate	VBN
cord-015021-pol2qm74	983	11	with	with	IN
cord-015021-pol2qm74	983	12	disturbances	disturbance	NNS
cord-015021-pol2qm74	983	13	in	in	IN
cord-015021-pol2qm74	983	14	cellular	cellular	JJ
cord-015021-pol2qm74	983	15	responses	response	NNS
cord-015021-pol2qm74	983	16	in	in	IN
cord-015021-pol2qm74	983	17	both	both	DT
cord-015021-pol2qm74	983	18	immune	immune	JJ
cord-015021-pol2qm74	983	19	and	and	CC
cord-015021-pol2qm74	983	20	non	non	JJ
cord-015021-pol2qm74	983	21	-	-	JJ
cord-015021-pol2qm74	983	22	immune	immune	JJ
cord-015021-pol2qm74	983	23	cells	cell	NNS
cord-015021-pol2qm74	983	24	during	during	IN
cord-015021-pol2qm74	983	25	sepsis	sepsis	NN
cord-015021-pol2qm74	983	26	.	.	.
cord-015021-pol2qm74	984	1	The	the	DT
cord-015021-pol2qm74	984	2	altered	altered	JJ
cord-015021-pol2qm74	984	3	cellular	cellular	JJ
cord-015021-pol2qm74	984	4	responses	response	NNS
cord-015021-pol2qm74	984	5	adversely	adversely	RB
cord-015021-pol2qm74	984	6	effect	effect	VBP
cord-015021-pol2qm74	984	7	the	the	DT
cord-015021-pol2qm74	984	8	outcome	outcome	NN
cord-015021-pol2qm74	984	9	of	of	IN
cord-015021-pol2qm74	984	10	the	the	DT
cord-015021-pol2qm74	984	11	septic	septic	JJ
cord-015021-pol2qm74	984	12	injury	injury	NN
cord-015021-pol2qm74	984	13	.	.	.
cord-015021-pol2qm74	985	1	(	(	-LRB-
cord-015021-pol2qm74	985	2	Supported	support	VBN
cord-015021-pol2qm74	985	3	by	by	IN
cord-015021-pol2qm74	985	4	NIH	NIH	NNP
cord-015021-pol2qm74	985	5	Grant	Grant	NNP
cord-015021-pol2qm74	985	6	GM	GM	NNP
cord-015021-pol2qm74	985	7	32288	32288	CD
cord-015021-pol2qm74	985	8	)	)	-RRB-
cord-015021-pol2qm74	985	9	.	.	.
cord-015021-pol2qm74	986	1	Alfred	Alfred	NNP
cord-015021-pol2qm74	986	2	Ayala	Ayala	NNP
cord-015021-pol2qm74	986	3	,	,	,
cord-015021-pol2qm74	986	4	Ping	Ping	NNP
cord-015021-pol2qm74	986	5	Wang	Wang	NNP
cord-015021-pol2qm74	986	6	and	and	CC
cord-015021-pol2qm74	986	7	Irshad	Irshad	NNP
cord-015021-pol2qm74	986	8	H.	H.	NNP
cord-015021-pol2qm74	986	9	Chaudry	Chaudry	NNP
cord-015021-pol2qm74	986	10	.	.	.
cord-015021-pol2qm74	987	1	Changes	change	NNS
cord-015021-pol2qm74	987	2	in	in	IN
cord-015021-pol2qm74	987	3	macrophage	macrophage	NN
cord-015021-pol2qm74	987	4	capacity	capacity	NN
cord-015021-pol2qm74	987	5	to	to	TO
cord-015021-pol2qm74	987	6	respond	respond	VB
cord-015021-pol2qm74	987	7	to	to	IN
cord-015021-pol2qm74	987	8	foreign	foreign	JJ
cord-015021-pol2qm74	987	9	pathogens	pathogen	NNS
cord-015021-pol2qm74	987	10	are	be	VBP
cord-015021-pol2qm74	987	11	thought	think	VBN
cord-015021-pol2qm74	987	12	to	to	TO
cord-015021-pol2qm74	987	13	be	be	VB
cord-015021-pol2qm74	987	14	central	central	JJ
cord-015021-pol2qm74	987	15	to	to	IN
cord-015021-pol2qm74	987	16	the	the	DT
cord-015021-pol2qm74	987	17	developing	develop	VBG
cord-015021-pol2qm74	987	18	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	987	19	associated	associate	VBN
cord-015021-pol2qm74	987	20	with	with	IN
cord-015021-pol2qm74	987	21	traumatic	traumatic	JJ
cord-015021-pol2qm74	987	22	injury	injury	NN
cord-015021-pol2qm74	987	23	.	.	.
cord-015021-pol2qm74	988	1	In	in	IN
cord-015021-pol2qm74	988	2	this	this	DT
cord-015021-pol2qm74	988	3	respect	respect	NN
cord-015021-pol2qm74	988	4	,	,	,
cord-015021-pol2qm74	988	5	the	the	DT
cord-015021-pol2qm74	988	6	suppression	suppression	NN
cord-015021-pol2qm74	988	7	seen	see	VBN
cord-015021-pol2qm74	988	8	in	in	IN
cord-015021-pol2qm74	988	9	M~	M~	NNP
cord-015021-pol2qm74	988	10	functions	function	NNS
cord-015021-pol2qm74	988	11	following	follow	VBG
cord-015021-pol2qm74	988	12	HEN	HEN	NNP
cord-015021-pol2qm74	988	13	(	(	-LRB-
cord-015021-pol2qm74	988	14	a	a	DT
cord-015021-pol2qm74	988	15	common	common	JJ
cord-015021-pol2qm74	988	16	component	component	NN
cord-015021-pol2qm74	988	17	of	of	IN
cord-015021-pol2qm74	988	18	traumatic	traumatic	JJ
cord-015021-pol2qm74	988	19	injury	injury	NN
cord-015021-pol2qm74	988	20	)	)	-RRB-
cord-015021-pol2qm74	988	21	may	may	MD
cord-015021-pol2qm74	988	22	be	be	VB
cord-015021-pol2qm74	988	23	mediated	mediate	VBN
cord-015021-pol2qm74	988	24	by	by	IN
cord-015021-pol2qm74	988	25	the	the	DT
cord-015021-pol2qm74	988	26	direct	direct	JJ
cord-015021-pol2qm74	988	27	or	or	CC
cord-015021-pol2qm74	988	28	indirect	indirect	JJ
cord-015021-pol2qm74	988	29	inhibition	inhibition	NN
cord-015021-pol2qm74	988	30	of	of	IN
cord-015021-pol2qm74	988	31	their	-PRON-	PRP$
cord-015021-pol2qm74	988	32	capacity	capacity	NN
cord-015021-pol2qm74	988	33	to	to	TO
cord-015021-pol2qm74	988	34	perceive	perceive	VB
cord-015021-pol2qm74	988	35	external	external	JJ
cord-015021-pol2qm74	988	36	stimuli	stimulus	NNS
cord-015021-pol2qm74	988	37	(	(	-LRB-
cord-015021-pol2qm74	988	38	e.g.	e.g.	RB
cord-015021-pol2qm74	988	39	,	,	,
cord-015021-pol2qm74	988	40	opsonized	opsonize	VBN
cord-015021-pol2qm74	988	41	&	&	CC
cord-015021-pol2qm74	988	42	non	non	JJ
cord-015021-pol2qm74	988	43	-	-	JJ
cord-015021-pol2qm74	988	44	opsonized	opsonized	JJ
cord-015021-pol2qm74	988	45	bacteria	bacteria	NNS
cord-015021-pol2qm74	988	46	,	,	,
cord-015021-pol2qm74	988	47	and	and	CC
cord-015021-pol2qm74	988	48	their	-PRON-	PRP$
cord-015021-pol2qm74	988	49	cellular	cellular	JJ
cord-015021-pol2qm74	988	50	components	component	NNS
cord-015021-pol2qm74	988	51	,	,	,
cord-015021-pol2qm74	988	52	etc	etc	FW
cord-015021-pol2qm74	988	53	.	.	.
cord-015021-pol2qm74	988	54	}	}	-RRB-
cord-015021-pol2qm74	989	1	due	due	IN
cord-015021-pol2qm74	989	2	to	to	IN
cord-015021-pol2qm74	989	3	the	the	DT
cord-015021-pol2qm74	989	4	breakdown	breakdown	NN
cord-015021-pol2qm74	989	5	of	of	IN
cord-015021-pol2qm74	989	6	the	the	DT
cord-015021-pol2qm74	989	7	receptormediated	receptormediated	JJ
cord-015021-pol2qm74	989	8	signal	signal	NN
cord-015021-pol2qm74	989	9	transduction	transduction	NN
cord-015021-pol2qm74	989	10	system	system	NN
cord-015021-pol2qm74	989	11	.	.	.
cord-015021-pol2qm74	990	1	Results	result	NNS
cord-015021-pol2qm74	990	2	of	of	IN
cord-015021-pol2qm74	990	3	a	a	DT
cord-015021-pol2qm74	990	4	number	number	NN
cord-015021-pol2qm74	990	5	of	of	IN
cord-015021-pol2qm74	990	6	studies	study	NNS
cord-015021-pol2qm74	990	7	by	by	IN
cord-015021-pol2qm74	990	8	our	-PRON-	PRP$
cord-015021-pol2qm74	990	9	laboratory	laboratory	NN
cord-015021-pol2qm74	990	10	and	and	CC
cord-015021-pol2qm74	990	11	others	other	NNS
cord-015021-pol2qm74	990	12	indicate	indicate	VBP
cord-015021-pol2qm74	990	13	that	that	IN
cord-015021-pol2qm74	990	14	this	this	DT
cord-015021-pol2qm74	990	15	inability	inability	NN
cord-015021-pol2qm74	990	16	to	to	TO
cord-015021-pol2qm74	990	17	respond	respond	VB
cord-015021-pol2qm74	990	18	to	to	IN
cord-015021-pol2qm74	990	19	external	external	JJ
cord-015021-pol2qm74	990	20	stimuli	stimulus	NNS
cord-015021-pol2qm74	990	21	is	be	VBZ
cord-015021-pol2qm74	990	22	in	in	IN
cord-015021-pol2qm74	990	23	part	part	NN
cord-015021-pol2qm74	990	24	due	due	IN
cord-015021-pol2qm74	990	25	to	to	IN
cord-015021-pol2qm74	990	26	the	the	DT
cord-015021-pol2qm74	990	27	loss	loss	NN
cord-015021-pol2qm74	990	28	of	of	IN
cord-015021-pol2qm74	990	29	cell	cell	NN
cord-015021-pol2qm74	990	30	surface	surface	NN
cord-015021-pol2qm74	990	31	receptors	receptor	NNS
cord-015021-pol2qm74	990	32	.	.	.
cord-015021-pol2qm74	991	1	Decreases	decrease	NNS
cord-015021-pol2qm74	991	2	have	have	VBP
cord-015021-pol2qm74	991	3	been	be	VBN
cord-015021-pol2qm74	991	4	documented	document	VBN
cord-015021-pol2qm74	991	5	for	for	IN
cord-015021-pol2qm74	991	6	not	not	RB
cord-015021-pol2qm74	991	7	only	only	RB
cord-015021-pol2qm74	991	8	la	la	JJ
cord-015021-pol2qm74	991	9	antigen	antigen	NNP
cord-015021-pol2qm74	991	10	,	,	,
cord-015021-pol2qm74	991	11	but	but	CC
cord-015021-pol2qm74	991	12	also	also	RB
cord-015021-pol2qm74	991	13	C3b	C3b	NNP
cord-015021-pol2qm74	991	14	,	,	,
cord-015021-pol2qm74	991	15	Fc	Fc	NNP
cord-015021-pol2qm74	991	16	,	,	,
cord-015021-pol2qm74	991	17	and	and	CC
cord-015021-pol2qm74	991	18	TNF	TNF	NNP
cord-015021-pol2qm74	991	19	receptors	receptor	NNS
cord-015021-pol2qm74	991	20	following	follow	VBG
cord-015021-pol2qm74	991	21	HEM	HEM	NNP
cord-015021-pol2qm74	991	22	in	in	IN
cord-015021-pol2qm74	991	23	mice	mouse	NNS
cord-015021-pol2qm74	991	24	.	.	.
cord-015021-pol2qm74	992	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	992	2	,	,	,
cord-015021-pol2qm74	992	3	studies	study	NNS
cord-015021-pol2qm74	992	4	which	which	WDT
cord-015021-pol2qm74	992	5	have	have	VBP
cord-015021-pol2qm74	992	6	examined	examine	VBN
cord-015021-pol2qm74	992	7	second	second	JJ
cord-015021-pol2qm74	992	8	messenger	messenger	NN
cord-015021-pol2qm74	992	9	generation	generation	NN
cord-015021-pol2qm74	992	10	in	in	IN
cord-015021-pol2qm74	992	11	these	these	DT
cord-015021-pol2qm74	992	12	cells	cell	NNS
cord-015021-pol2qm74	992	13	indicate	indicate	VBP
cord-015021-pol2qm74	992	14	that	that	IN
cord-015021-pol2qm74	992	15	M~	M~	NNP
cord-015021-pol2qm74	992	16	derived	derive	VBN
cord-015021-pol2qm74	992	17	from	from	IN
cord-015021-pol2qm74	992	18	the	the	DT
cord-015021-pol2qm74	992	19	peritoneum	peritoneum	NN
cord-015021-pol2qm74	992	20	and	and	CC
cord-015021-pol2qm74	992	21	spleen	spleen	NNS
cord-015021-pol2qm74	992	22	exhibit	exhibit	VBP
cord-015021-pol2qm74	992	23	a	a	DT
cord-015021-pol2qm74	992	24	decreased	decrease	VBN
cord-015021-pol2qm74	992	25	capacity	capacity	NN
cord-015021-pol2qm74	992	26	to	to	TO
cord-015021-pol2qm74	992	27	mobilize	mobilize	VB
cord-015021-pol2qm74	992	28	Ca	Ca	NNP
cord-015021-pol2qm74	992	29	+2	+2	NN
cord-015021-pol2qm74	992	30	from	from	IN
cord-015021-pol2qm74	992	31	intracellular	intracellular	JJ
cord-015021-pol2qm74	992	32	stores	store	NNS
cord-015021-pol2qm74	992	33	.	.	.
cord-015021-pol2qm74	993	1	This	this	DT
cord-015021-pol2qm74	993	2	protein	protein	NN
cord-015021-pol2qm74	993	3	kinase	kinase	VBZ
cord-015021-pol2qm74	993	4	dependent	dependent	JJ
cord-015021-pol2qm74	993	5	process	process	NN
cord-015021-pol2qm74	993	6	of	of	IN
cord-015021-pol2qm74	993	7	[	[	-LRB-
cord-015021-pol2qm74	993	8	Ca+2	Ca+2	NNP
cord-015021-pol2qm74	993	9	]	]	-RRB-
cord-015021-pol2qm74	994	1	i	i	PRP
cord-015021-pol2qm74	994	2	mobilization	mobilization	NN
cord-015021-pol2qm74	994	3	appears	appear	VBZ
cord-015021-pol2qm74	994	4	to	to	TO
cord-015021-pol2qm74	994	5	be	be	VB
cord-015021-pol2qm74	994	6	linked	link	VBN
cord-015021-pol2qm74	994	7	to	to	IN
cord-015021-pol2qm74	994	8	the	the	DT
cord-015021-pol2qm74	994	9	inability	inability	NN
cord-015021-pol2qm74	994	10	to	to	TO
cord-015021-pol2qm74	994	11	synthesize	synthesize	VB
cord-015021-pol2qm74	994	12	inositol	inositol	NN
cord-015021-pol2qm74	994	13	triphosphate	triphosphate	NN
cord-015021-pol2qm74	994	14	.	.	.
cord-015021-pol2qm74	995	1	Of	of	IN
cord-015021-pol2qm74	995	2	interest	interest	NN
cord-015021-pol2qm74	995	3	,	,	,
cord-015021-pol2qm74	995	4	the	the	DT
cord-015021-pol2qm74	995	5	depression	depression	NN
cord-015021-pol2qm74	995	6	in	in	IN
cord-015021-pol2qm74	995	7	Ca	Ca	NNP
cord-015021-pol2qm74	995	8	+2	+2	NN
cord-015021-pol2qm74	995	9	signal	signal	JJ
cord-015021-pol2qm74	995	10	generation	generation	NN
cord-015021-pol2qm74	995	11	appears	appear	VBZ
cord-015021-pol2qm74	995	12	to	to	TO
cord-015021-pol2qm74	995	13	be	be	VB
cord-015021-pol2qm74	995	14	inversely	inversely	RB
cord-015021-pol2qm74	995	15	related	relate	VBN
cord-015021-pol2qm74	995	16	to	to	IN
cord-015021-pol2qm74	995	17	presence	presence	NN
cord-015021-pol2qm74	995	18	of	of	IN
cord-015021-pol2qm74	995	19	elevated	elevated	JJ
cord-015021-pol2qm74	995	20	levels	level	NNS
cord-015021-pol2qm74	995	21	of	of	IN
cord-015021-pol2qm74	995	22	cAMP	camp	NN
cord-015021-pol2qm74	995	23	in	in	IN
cord-015021-pol2qm74	995	24	M~	M~	NNP
cord-015021-pol2qm74	995	25	from	from	IN
cord-015021-pol2qm74	995	26	HEN	HEN	NNP
cord-015021-pol2qm74	995	27	mice	mouse	NNS
cord-015021-pol2qm74	995	28	.	.	.
cord-015021-pol2qm74	996	1	We	-PRON-	PRP
cord-015021-pol2qm74	996	2	have	have	VBP
cord-015021-pol2qm74	996	3	reported	report	VBN
cord-015021-pol2qm74	996	4	that	that	IN
cord-015021-pol2qm74	996	5	M~	m~	IN
cord-015021-pol2qm74	996	6	priming	prime	VBG
cord-015021-pol2qm74	996	7	agents	agent	NNS
cord-015021-pol2qm74	996	8	,	,	,
cord-015021-pol2qm74	996	9	such	such	JJ
cord-015021-pol2qm74	996	10	as	as	IN
cord-015021-pol2qm74	996	11	IFN-7	IFN-7	NNP
cord-015021-pol2qm74	996	12	(	(	-LRB-
cord-015021-pol2qm74	996	13	which	which	WDT
cord-015021-pol2qm74	996	14	exhibits	exhibit	VBZ
cord-015021-pol2qm74	996	15	salutary	salutary	JJ
cord-015021-pol2qm74	996	16	effects	effect	NNS
cord-015021-pol2qm74	996	17	on	on	IN
cord-015021-pol2qm74	996	18	M~	m~	NN
cord-015021-pol2qm74	996	19	function	function	NN
cord-015021-pol2qm74	996	20	following	follow	VBG
cord-015021-pol2qm74	996	21	HEM	HEM	NNP
cord-015021-pol2qm74	996	22	)	)	-RRB-
cord-015021-pol2qm74	996	23	,	,	,
cord-015021-pol2qm74	996	24	appear	appear	VBP
cord-015021-pol2qm74	996	25	to	to	TO
cord-015021-pol2qm74	996	26	restore	restore	VB
cord-015021-pol2qm74	996	27	cell	cell	NN
cord-015021-pol2qm74	996	28	signal	signal	NN
cord-015021-pol2qm74	996	29	transductive	transductive	NNP
cord-015021-pol2qm74	996	30	capacity	capacity	NN
cord-015021-pol2qm74	996	31	while	while	IN
cord-015021-pol2qm74	996	32	reducing	reduce	VBG
cord-015021-pol2qm74	996	33	the	the	DT
cord-015021-pol2qm74	996	34	levels	level	NNS
cord-015021-pol2qm74	996	35	of	of	IN
cord-015021-pol2qm74	996	36	cAMP	camp	NN
cord-015021-pol2qm74	996	37	.	.	.
cord-015021-pol2qm74	997	1	Nonetheless	nonetheless	RB
cord-015021-pol2qm74	997	2	,	,	,
cord-015021-pol2qm74	997	3	the	the	DT
cord-015021-pol2qm74	997	4	extent	extent	NN
cord-015021-pol2qm74	997	5	to	to	TO
cord-015021-pol2qm74	997	6	which	which	WDT
cord-015021-pol2qm74	997	7	depressed	depressed	JJ
cord-015021-pol2qm74	997	8	receptor	receptor	NN
cord-015021-pol2qm74	997	9	signal	signal	NN
cord-015021-pol2qm74	997	10	transduction	transduction	NN
cord-015021-pol2qm74	997	11	in	in	IN
cord-015021-pol2qm74	997	12	HEM	HEM	NNP
cord-015021-pol2qm74	997	13	,	,	,
cord-015021-pol2qm74	997	14	is	be	VBZ
cord-015021-pol2qm74	997	15	due	due	JJ
cord-015021-pol2qm74	997	16	to	to	IN
cord-015021-pol2qm74	997	17	receptor	receptor	NN
cord-015021-pol2qm74	997	18	loss	loss	NN
cord-015021-pol2qm74	997	19	~	~	NFP
cord-015021-pol2qm74	997	20	dysfunction	dysfunction	NN
cord-015021-pol2qm74	997	21	or	or	CC
cord-015021-pol2qm74	997	22	elevated	elevate	VBN
cord-015021-pol2qm74	997	23	antagonistic	antagonistic	JJ
cord-015021-pol2qm74	997	24	second	second	JJ
cord-015021-pol2qm74	997	25	messenger	messenger	NN
cord-015021-pol2qm74	997	26	levels	level	NNS
cord-015021-pol2qm74	997	27	remains	remain	VBZ
cord-015021-pol2qm74	997	28	to	to	TO
cord-015021-pol2qm74	997	29	be	be	VB
cord-015021-pol2qm74	997	30	determined	determine	VBN
cord-015021-pol2qm74	997	31	.	.	.
cord-015021-pol2qm74	998	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	998	2	:	:	:
cord-015021-pol2qm74	999	1	Significant	significant	JJ
cord-015021-pol2qm74	999	2	impairment	impairment	NN
cord-015021-pol2qm74	999	3	of	of	IN
cord-015021-pol2qm74	999	4	calcium	calcium	NN
cord-015021-pol2qm74	999	5	signaling	signaling	NN
cord-015021-pol2qm74	999	6	occurs	occur	VBZ
cord-015021-pol2qm74	999	7	at	at	IN
cord-015021-pol2qm74	999	8	all	all	DT
cord-015021-pol2qm74	999	9	time	time	NN
cord-015021-pol2qm74	999	10	-	-	HYPH
cord-015021-pol2qm74	999	11	points	point	NNS
cord-015021-pol2qm74	999	12	prior	prior	RB
cord-015021-pol2qm74	999	13	to	to	IN
cord-015021-pol2qm74	999	14	and	and	CC
cord-015021-pol2qm74	999	15	following	follow	VBG
cord-015021-pol2qm74	999	16	PHA	PHA	NNP
cord-015021-pol2qm74	999	17	stimulation	stimulation	NN
cord-015021-pol2qm74	999	18	in	in	IN
cord-015021-pol2qm74	999	19	trauma	trauma	NN
cord-015021-pol2qm74	999	20	patients	patient	NNS
cord-015021-pol2qm74	999	21	.	.	.
cord-015021-pol2qm74	1000	1	Tcell	Tcell	NNP
cord-015021-pol2qm74	1000	2	activation	activation	NN
cord-015021-pol2qm74	1000	3	failure	failure	NN
cord-015021-pol2qm74	1000	4	can	can	MD
cord-015021-pol2qm74	1000	5	,	,	,
cord-015021-pol2qm74	1000	6	in	in	IN
cord-015021-pol2qm74	1000	7	part	part	NN
cord-015021-pol2qm74	1000	8	,	,	,
cord-015021-pol2qm74	1000	9	be	be	VB
cord-015021-pol2qm74	1000	10	explained	explain	VBN
cord-015021-pol2qm74	1000	11	by	by	IN
cord-015021-pol2qm74	1000	12	the	the	DT
cord-015021-pol2qm74	1000	13	inadequacy	inadequacy	NN
cord-015021-pol2qm74	1000	14	of	of	IN
cord-015021-pol2qm74	1000	15	this	this	DT
cord-015021-pol2qm74	1000	16	essential	essential	JJ
cord-015021-pol2qm74	1000	17	intracellular	intracellular	JJ
cord-015021-pol2qm74	1000	18	second	second	JJ
cord-015021-pol2qm74	1000	19	messenger	messenger	NN
cord-015021-pol2qm74	1000	20	system	system	NN
cord-015021-pol2qm74	1000	21	.	.	.
cord-015021-pol2qm74	1001	1	Restoration	restoration	NN
cord-015021-pol2qm74	1001	2	of	of	IN
cord-015021-pol2qm74	1001	3	immunocompetence	immunocompetence	NN
cord-015021-pol2qm74	1001	4	following	follow	VBG
cord-015021-pol2qm74	1001	5	trauma	trauma	NN
cord-015021-pol2qm74	1001	6	will	will	MD
cord-015021-pol2qm74	1001	7	have	have	VB
cord-015021-pol2qm74	1001	8	to	to	TO
cord-015021-pol2qm74	1001	9	address	address	VB
cord-015021-pol2qm74	1001	10	strategies	strategy	NNS
cord-015021-pol2qm74	1001	11	to	to	TO
cord-015021-pol2qm74	1001	12	better	better	RB
cord-015021-pol2qm74	1001	13	assess	assess	VB
cord-015021-pol2qm74	1001	14	and	and	CC
cord-015021-pol2qm74	1001	15	restore	restore	VB
cord-015021-pol2qm74	1001	16	this	this	DT
cord-015021-pol2qm74	1001	17	vital	vital	JJ
cord-015021-pol2qm74	1001	18	step	step	NN
cord-015021-pol2qm74	1001	19	in	in	IN
cord-015021-pol2qm74	1001	20	the	the	DT
cord-015021-pol2qm74	1001	21	activation	activation	NN
cord-015021-pol2qm74	1001	22	sequence	sequence	NN
cord-015021-pol2qm74	1001	23	leading	lead	VBG
cord-015021-pol2qm74	1001	24	to	to	IN
cord-015021-pol2qm74	1001	25	proliferation	proliferation	NN
cord-015021-pol2qm74	1001	26	during	during	IN
cord-015021-pol2qm74	1001	27	the	the	DT
cord-015021-pol2qm74	1001	28	antigen	antigen	NN
cord-015021-pol2qm74	1001	29	recognition	recognition	NN
cord-015021-pol2qm74	1001	30	process	process	NN
cord-015021-pol2qm74	1001	31	.	.	.
cord-015021-pol2qm74	1002	1	Patrick	Patrick	NNP
cord-015021-pol2qm74	1002	2	A.	a.	NN
cord-015021-pol2qm74	1002	3	Bseuerle	Bseuerle	NNP
cord-015021-pol2qm74	1002	4	Institute	Institute	NNP
cord-015021-pol2qm74	1002	5	01	01	CD
cord-015021-pol2qm74	1002	6	Biochemistry	Biochemistry	NNP
cord-015021-pol2qm74	1002	7	,	,	,
cord-015021-pol2qm74	1002	8	Albert	Albert	NNP
cord-015021-pol2qm74	1002	9	-	-	HYPH
cord-015021-pol2qm74	1002	10	Ludwigs	Ludwigs	NNP
cord-015021-pol2qm74	1002	11	-	-	HYPH
cord-015021-pol2qm74	1002	12	University	University	NNP
cord-015021-pol2qm74	1002	13	,	,	,
cord-015021-pol2qm74	1002	14	Hermann	Hermann	NNP
cord-015021-pol2qm74	1002	15	-	-	HYPH
cord-015021-pol2qm74	1002	16	Herder	Herder	NNP
cord-015021-pol2qm74	1002	17	-	-	HYPH
cord-015021-pol2qm74	1002	18	Str	Str	NNP
cord-015021-pol2qm74	1002	19	.	.	NNP
cord-015021-pol2qm74	1002	20	7	7	CD
cord-015021-pol2qm74	1002	21	,	,	,
cord-015021-pol2qm74	1002	22	D-79104	D-79104	NNP
cord-015021-pol2qm74	1002	23	Freiburg	Freiburg	NNP
cord-015021-pol2qm74	1002	24	,	,	,
cord-015021-pol2qm74	1002	25	Germany	Germany	NNP
cord-015021-pol2qm74	1003	1	The	the	DT
cord-015021-pol2qm74	1003	2	active	active	JJ
cord-015021-pol2qm74	1003	3	form	form	NN
cord-015021-pol2qm74	1003	4	of	of	IN
cord-015021-pol2qm74	1003	5	the	the	DT
cord-015021-pol2qm74	1003	6	transcriptional	transcriptional	JJ
cord-015021-pol2qm74	1003	7	activator	activator	NN
cord-015021-pol2qm74	1003	8	NF-~B	NF-~B	NNP
cord-015021-pol2qm74	1003	9	is	be	VBZ
cord-015021-pol2qm74	1003	10	a	a	DT
cord-015021-pol2qm74	1003	11	heteredimer	heteredimer	NN
cord-015021-pol2qm74	1003	12	composed	compose	VBN
cord-015021-pol2qm74	1003	13	of	of	IN
cord-015021-pol2qm74	1003	14	a	a	DT
cord-015021-pol2qm74	1003	15	50	50	CD
cord-015021-pol2qm74	1003	16	and	and	CC
cord-015021-pol2qm74	1003	17	65	65	CD
cord-015021-pol2qm74	1003	18	kDa	kDa	NNP
cord-015021-pol2qm74	1003	19	polypeptide	polypeptide	NN
cord-015021-pol2qm74	1003	20	.	.	.
cord-015021-pol2qm74	1004	1	In	in	IN
cord-015021-pol2qm74	1004	2	this	this	DT
cord-015021-pol2qm74	1004	3	form	form	NN
cord-015021-pol2qm74	1004	4	,	,	,
cord-015021-pol2qm74	1004	5	NF-'<B	NF-'<B	NNP
cord-015021-pol2qm74	1004	6	can	can	MD
cord-015021-pol2qm74	1004	7	bind	bind	VB
cord-015021-pol2qm74	1004	8	with	with	IN
cord-015021-pol2qm74	1004	9	high	high	JJ
cord-015021-pol2qm74	1004	10	affinity	affinity	NN
cord-015021-pol2qm74	1004	11	to	to	IN
cord-015021-pol2qm74	1004	12	decameric	decameric	JJ
cord-015021-pol2qm74	1004	13	sequence	sequence	NN
cord-015021-pol2qm74	1004	14	motifs	motif	NNS
cord-015021-pol2qm74	1004	15	(	(	-LRB-
cord-015021-pol2qm74	1004	16	consensus	consensus	NN
cord-015021-pol2qm74	1004	17	:	:	:
cord-015021-pol2qm74	1004	18	5"-GGGPuNNF'yPyCC-3	5"-gggpunnf'ypycc-3	CD
cord-015021-pol2qm74	1004	19	"	"	''
cord-015021-pol2qm74	1004	20	)	)	-RRB-
cord-015021-pol2qm74	1004	21	found	find	VBN
cord-015021-pol2qm74	1004	22	in	in	IN
cord-015021-pol2qm74	1004	23	enhancers	enhancer	NNS
cord-015021-pol2qm74	1004	24	and	and	CC
cord-015021-pol2qm74	1004	25	promoters	promoter	NNS
cord-015021-pol2qm74	1004	26	of	of	IN
cord-015021-pol2qm74	1004	27	many	many	JJ
cord-015021-pol2qm74	1004	28	genes	gene	NNS
cord-015021-pol2qm74	1004	29	activated	activate	VBN
cord-015021-pol2qm74	1004	30	upon	upon	IN
cord-015021-pol2qm74	1004	31	a	a	DT
cord-015021-pol2qm74	1004	32	wide	wide	JJ
cord-015021-pol2qm74	1004	33	variety	variety	NN
cord-015021-pol2qm74	1004	34	of	of	IN
cord-015021-pol2qm74	1004	35	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	1004	36	conditions	condition	NNS
cord-015021-pol2qm74	1004	37	,	,	,
cord-015021-pol2qm74	1004	38	including	include	VBG
cord-015021-pol2qm74	1004	39	viral	viral	JJ
cord-015021-pol2qm74	1004	40	and	and	CC
cord-015021-pol2qm74	1004	41	bactedaI	bactedai	CD
cord-015021-pol2qm74	1004	42	infections	infection	NNS
cord-015021-pol2qm74	1004	43	,	,	,
cord-015021-pol2qm74	1004	44	acute	acute	JJ
cord-015021-pol2qm74	1004	45	phase	phase	NN
cord-015021-pol2qm74	1004	46	response	response	NN
cord-015021-pol2qm74	1004	47	,	,	,
cord-015021-pol2qm74	1004	48	oxidative	oxidative	JJ
cord-015021-pol2qm74	1004	49	stress	stress	NN
cord-015021-pol2qm74	1004	50	and	and	CC
cord-015021-pol2qm74	1004	51	UV	uv	NN
cord-015021-pol2qm74	1004	52	and	and	CC
cord-015021-pol2qm74	1004	53	gamma	gamma	NN
cord-015021-pol2qm74	1004	54	irradation	irradation	NN
cord-015021-pol2qm74	1004	55	.	.	.
cord-015021-pol2qm74	1005	1	Clinically	clinically	RB
cord-015021-pol2qm74	1005	2	important	important	JJ
cord-015021-pol2qm74	1005	3	target	target	NN
cord-015021-pol2qm74	1005	4	genes	gene	NNS
cord-015021-pol2qm74	1005	5	for	for	IN
cord-015021-pol2qm74	1005	6	NF	nf	NN
cord-015021-pol2qm74	1005	7	-	-	HYPH
cord-015021-pol2qm74	1005	8	K	k	NN
cord-015021-pol2qm74	1006	1	:	:	:
cord-015021-pol2qm74	1006	2	B	b	NN
cord-015021-pol2qm74	1006	3	encode	encode	VB
cord-015021-pol2qm74	1006	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1006	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	1006	6	(	(	-LRB-
cord-015021-pol2qm74	1006	7	IL-1B	IL-1B	NNP
cord-015021-pol2qm74	1006	8	,	,	,
cord-015021-pol2qm74	1006	9	TNF	TNF	NNP
cord-015021-pol2qm74	1006	10	,	,	,
cord-015021-pol2qm74	1006	11	[	[	-LRB-
cord-015021-pol2qm74	1006	12	L-6	L-6	NNP
cord-015021-pol2qm74	1006	13	,	,	,
cord-015021-pol2qm74	1006	14	IL-8	IL-8	NNP
cord-015021-pol2qm74	1006	15	,	,	,
cord-015021-pol2qm74	1006	16	GM	GM	NNP
cord-015021-pol2qm74	1006	17	-	-	HYPH
cord-015021-pol2qm74	1006	18	CSF	CSF	NNP
cord-015021-pol2qm74	1006	19	etc	etc	NN
cord-015021-pol2qm74	1006	20	)	)	-RRB-
cord-015021-pol2qm74	1006	21	,	,	,
cord-015021-pol2qm74	1006	22	cell	cell	NN
cord-015021-pol2qm74	1006	23	adhesion	adhesion	NN
cord-015021-pol2qm74	1006	24	molecules	molecule	NNS
cord-015021-pol2qm74	1006	25	(	(	-LRB-
cord-015021-pol2qm74	1006	26	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1006	27	,	,	,
cord-015021-pol2qm74	1006	28	ELAM-1	ELAM-1	NNP
cord-015021-pol2qm74	1006	29	,	,	,
cord-015021-pol2qm74	1006	30	VCAM-1	VCAM-1	NNP
cord-015021-pol2qm74	1006	31	)	)	-RRB-
cord-015021-pol2qm74	1006	32	,	,	,
cord-015021-pol2qm74	1006	33	acute	acute	JJ
cord-015021-pol2qm74	1006	34	phase	phase	NN
cord-015021-pol2qm74	1006	35	proteins	protein	NNS
cord-015021-pol2qm74	1006	36	and	and	CC
cord-015021-pol2qm74	1006	37	immunoregulatory	immunoregulatory	JJ
cord-015021-pol2qm74	1006	38	ceil	ceil	NNP
cord-015021-pol2qm74	1006	39	surface	surface	NN
cord-015021-pol2qm74	1006	40	receptors	receptor	NNS
cord-015021-pol2qm74	1006	41	.	.	.
cord-015021-pol2qm74	1007	1	In	in	IN
cord-015021-pol2qm74	1007	2	most	most	JJS
cord-015021-pol2qm74	1007	3	cell	cell	NN
cord-015021-pol2qm74	1007	4	types	type	NNS
cord-015021-pol2qm74	1007	5	,	,	,
cord-015021-pol2qm74	1007	6	NF-~:B	NF-~:B	NNP
cord-015021-pol2qm74	1007	7	is	be	VBZ
cord-015021-pol2qm74	1007	8	sequestered	sequester	VBN
cord-015021-pol2qm74	1007	9	in	in	IN
cord-015021-pol2qm74	1007	10	the	the	DT
cord-015021-pol2qm74	1007	11	cytoplasm	cytoplasm	NN
cord-015021-pol2qm74	1007	12	and	and	CC
cord-015021-pol2qm74	1007	13	,	,	,
cord-015021-pol2qm74	1007	14	therefore	therefore	RB
cord-015021-pol2qm74	1007	15	,	,	,
cord-015021-pol2qm74	1007	16	unable	unable	JJ
cord-015021-pol2qm74	1007	17	to	to	TO
cord-015021-pol2qm74	1007	18	initiate	initiate	VB
cord-015021-pol2qm74	1007	19	transcription	transcription	NN
cord-015021-pol2qm74	1007	20	of	of	IN
cord-015021-pol2qm74	1007	21	these	these	DT
cord-015021-pol2qm74	1007	22	genes	gene	NNS
cord-015021-pol2qm74	1007	23	.	.	.
cord-015021-pol2qm74	1008	1	The	the	DT
cord-015021-pol2qm74	1008	2	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	1008	3	form	form	NN
cord-015021-pol2qm74	1008	4	of	of	IN
cord-015021-pol2qm74	1008	5	NF-~:B	NF-~:B	NNP
cord-015021-pol2qm74	1008	6	contains	contain	VBZ
cord-015021-pol2qm74	1008	7	one	one	CD
cord-015021-pol2qm74	1008	8	additionaI	additionaI	NNP
cord-015021-pol2qm74	1008	9	subunit	subunit	NN
cord-015021-pol2qm74	1008	10	,	,	,
cord-015021-pol2qm74	1008	11	referred	refer	VBD
cord-015021-pol2qm74	1008	12	to	to	IN
cord-015021-pol2qm74	1008	13	as	as	IN
cord-015021-pol2qm74	1008	14	h,;:B.	h,;:B.	NNP
cord-015021-pol2qm74	1009	1	I	-PRON-	PRP
cord-015021-pol2qm74	1010	1	~B	~B	NFP
cord-015021-pol2qm74	1010	2	can	can	MD
cord-015021-pol2qm74	1010	3	reversibly	reversibly	RB
cord-015021-pol2qm74	1010	4	suppress	suppress	VB
cord-015021-pol2qm74	1010	5	DNA	dna	NN
cord-015021-pol2qm74	1010	6	binding	binding	NN
cord-015021-pol2qm74	1010	7	and	and	CC
cord-015021-pol2qm74	1010	8	nuclear	nuclear	JJ
cord-015021-pol2qm74	1010	9	uptake	uptake	NN
cord-015021-pol2qm74	1010	10	of	of	IN
cord-015021-pol2qm74	1010	11	NF-~B	NF-~B	NNP
cord-015021-pol2qm74	1010	12	by	by	IN
cord-015021-pol2qm74	1010	13	virtue	virtue	NN
cord-015021-pol2qm74	1010	14	of	of	IN
cord-015021-pol2qm74	1010	15	its	-PRON-	PRP$
cord-015021-pol2qm74	1010	16	association	association	NN
cord-015021-pol2qm74	1010	17	with	with	IN
cord-015021-pol2qm74	1010	18	p65	p65	ADD
cord-015021-pol2qm74	1010	19	.	.	.
cord-015021-pol2qm74	1011	1	Upon	upon	IN
cord-015021-pol2qm74	1011	2	stimulation	stimulation	NN
cord-015021-pol2qm74	1011	3	of	of	IN
cord-015021-pol2qm74	1011	4	cells	cell	NNS
cord-015021-pol2qm74	1011	5	,	,	,
cord-015021-pol2qm74	1011	6	IKB	IKB	NNP
cord-015021-pol2qm74	1011	7	is	be	VBZ
cord-015021-pol2qm74	1011	8	proteolytically	proteolytically	RB
cord-015021-pol2qm74	1011	9	destroyed	destroy	VBN
cord-015021-pol2qm74	1011	10	,	,	,
cord-015021-pol2qm74	1011	11	allowing	allow	VBG
cord-015021-pol2qm74	1011	12	NF	NF	NNP
cord-015021-pol2qm74	1011	13	-	-	HYPH
cord-015021-pol2qm74	1011	14	KB	KB	NNP
cord-015021-pol2qm74	1011	15	to	to	TO
cord-015021-pol2qm74	1011	16	enter	enter	VB
cord-015021-pol2qm74	1011	17	the	the	DT
cord-015021-pol2qm74	1011	18	nucleus	nucleus	NN
cord-015021-pol2qm74	1011	19	and	and	CC
cord-015021-pol2qm74	1011	20	activate	activate	VB
cord-015021-pol2qm74	1011	21	genes	gene	NNS
cord-015021-pol2qm74	1011	22	upon	upon	IN
cord-015021-pol2qm74	1011	23	binding	bind	VBG
cord-015021-pol2qm74	1011	24	to	to	IN
cord-015021-pol2qm74	1011	25	transcriptional	transcriptional	JJ
cord-015021-pol2qm74	1011	26	enhancers	enhancer	NNS
cord-015021-pol2qm74	1011	27	.	.	.
cord-015021-pol2qm74	1012	1	We	-PRON-	PRP
cord-015021-pol2qm74	1012	2	have	have	VBP
cord-015021-pol2qm74	1012	3	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	1012	4	that	that	IN
cord-015021-pol2qm74	1012	5	various	various	JJ
cord-015021-pol2qm74	1012	6	antioxidative	antioxidative	JJ
cord-015021-pol2qm74	1012	7	compounds	compound	NNS
cord-015021-pol2qm74	1012	8	inhibit	inhibit	VBP
cord-015021-pol2qm74	1012	9	the	the	DT
cord-015021-pol2qm74	1012	10	activation	activation	NN
cord-015021-pol2qm74	1012	11	of	of	IN
cord-015021-pol2qm74	1012	12	NF-~B	NF-~B	NNP
cord-015021-pol2qm74	1012	13	in	in	IN
cord-015021-pol2qm74	1012	14	response	response	NN
cord-015021-pol2qm74	1012	15	to	to	IN
cord-015021-pol2qm74	1012	16	many	many	JJ
cord-015021-pol2qm74	1012	17	inducers	inducer	NNS
cord-015021-pol2qm74	1012	18	.	.	.
cord-015021-pol2qm74	1013	1	Moreover	moreover	RB
cord-015021-pol2qm74	1013	2	,	,	,
cord-015021-pol2qm74	1013	3	NF-~:B	NF-~:B	NNP
cord-015021-pol2qm74	1013	4	was	be	VBD
cord-015021-pol2qm74	1013	5	shown	show	VBN
cord-015021-pol2qm74	1013	6	to	to	TO
cord-015021-pol2qm74	1013	7	be	be	VB
cord-015021-pol2qm74	1013	8	activated	activate	VBN
cord-015021-pol2qm74	1013	9	upon	upon	IN
cord-015021-pol2qm74	1013	10	treatment	treatment	NN
cord-015021-pol2qm74	1013	11	of	of	IN
cord-015021-pol2qm74	1013	12	cell	cell	NN
cord-015021-pol2qm74	1013	13	cultures	culture	NNS
cord-015021-pol2qm74	1013	14	with	with	IN
cord-015021-pol2qm74	1013	15	p.	p.	NN
cord-015021-pol2qm74	1014	1	M	M	NNP
cord-015021-pol2qm74	1014	2	-	-	HYPH
cord-015021-pol2qm74	1014	3	amounts	amount	NNS
cord-015021-pol2qm74	1014	4	of	of	IN
cord-015021-pol2qm74	1014	5	hydrogen	hydrogen	NN
cord-015021-pol2qm74	1014	6	peroxide	peroxide	NN
cord-015021-pol2qm74	1014	7	.	.	.
cord-015021-pol2qm74	1015	1	These	these	DT
cord-015021-pol2qm74	1015	2	data	datum	NNS
cord-015021-pol2qm74	1015	3	suggested	suggest	VBD
cord-015021-pol2qm74	1015	4	that	that	IN
cord-015021-pol2qm74	1015	5	NF-~B	NF-~B	NNP
cord-015021-pol2qm74	1015	6	prinicipaliy	prinicipaliy	NNP
cord-015021-pol2qm74	1015	7	is	be	VBZ
cord-015021-pol2qm74	1015	8	an	an	DT
cord-015021-pol2qm74	1015	9	oxidative	oxidative	JJ
cord-015021-pol2qm74	1015	10	stress	stress	NN
cord-015021-pol2qm74	1015	11	-	-	HYPH
cord-015021-pol2qm74	1015	12	responsive	responsive	JJ
cord-015021-pol2qm74	1015	13	transcnption	transcnption	NN
cord-015021-pol2qm74	1015	14	factor	factor	NN
cord-015021-pol2qm74	1015	15	.	.	.
cord-015021-pol2qm74	1016	1	The	the	DT
cord-015021-pol2qm74	1016	2	notion	notion	NN
cord-015021-pol2qm74	1016	3	is	be	VBZ
cord-015021-pol2qm74	1016	4	supported	support	VBN
cord-015021-pol2qm74	1016	5	by	by	IN
cord-015021-pol2qm74	1016	6	numerous	numerous	JJ
cord-015021-pol2qm74	1016	7	reports	report	NNS
cord-015021-pol2qm74	1016	8	on	on	IN
cord-015021-pol2qm74	1016	9	the	the	DT
cord-015021-pol2qm74	1016	10	induction	induction	NN
cord-015021-pol2qm74	1016	11	of	of	IN
cord-015021-pol2qm74	1016	12	oxidative	oxidative	JJ
cord-015021-pol2qm74	1016	13	stress	stress	NN
cord-015021-pol2qm74	1016	14	by	by	IN
cord-015021-pol2qm74	1016	15	many	many	JJ
cord-015021-pol2qm74	1016	16	NF	nf	NN
cord-015021-pol2qm74	1016	17	-	-	HYPH
cord-015021-pol2qm74	1016	18	nB	nb	RB
cord-015021-pol2qm74	1016	19	-	-	HYPH
cord-015021-pol2qm74	1016	20	inducing	induce	VBG
cord-015021-pol2qm74	1016	21	agents	agent	NNS
cord-015021-pol2qm74	1016	22	.	.	.
cord-015021-pol2qm74	1017	1	NF-~B	nf-~b	JJ
cord-015021-pol2qm74	1017	2	activition	activition	NN
cord-015021-pol2qm74	1017	3	can	can	MD
cord-015021-pol2qm74	1017	4	likewise	likewise	RB
cord-015021-pol2qm74	1017	5	be	be	VB
cord-015021-pol2qm74	1017	6	suppressed	suppress	VBN
cord-015021-pol2qm74	1017	7	by	by	IN
cord-015021-pol2qm74	1017	8	protease	protease	NN
cord-015021-pol2qm74	1017	9	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	1017	10	.	.	.
cord-015021-pol2qm74	1018	1	These	these	DT
cord-015021-pol2qm74	1018	2	drugs	drug	NNS
cord-015021-pol2qm74	1018	3	apparently	apparently	RB
cord-015021-pol2qm74	1018	4	inhibit	inhibit	VBP
cord-015021-pol2qm74	1018	5	a	a	DT
cord-015021-pol2qm74	1018	6	yet	yet	RB
cord-015021-pol2qm74	1018	7	unidentified	unidentified	JJ
cord-015021-pol2qm74	1018	8	protease	protease	NN
cord-015021-pol2qm74	1018	9	responsible	responsible	JJ
cord-015021-pol2qm74	1018	10	for	for	IN
cord-015021-pol2qm74	1018	11	the	the	DT
cord-015021-pol2qm74	1018	12	inducible	inducible	JJ
cord-015021-pol2qm74	1018	13	decay	decay	NN
cord-015021-pol2qm74	1018	14	of	of	IN
cord-015021-pol2qm74	1018	15	InB.	InB.	NNP
cord-015021-pol2qm74	1019	1	We	-PRON-	PRP
cord-015021-pol2qm74	1019	2	propose	propose	VBP
cord-015021-pol2qm74	1019	3	to	to	TO
cord-015021-pol2qm74	1019	4	use	use	VB
cord-015021-pol2qm74	1019	5	NF	NF	NNP
cord-015021-pol2qm74	1019	6	-	-	HYPH
cord-015021-pol2qm74	1019	7	nB	nB	NNP
cord-015021-pol2qm74	1019	8	inhibifors	inhibifor	NNS
cord-015021-pol2qm74	1019	9	as	as	IN
cord-015021-pol2qm74	1019	10	novel	novel	JJ
cord-015021-pol2qm74	1019	11	drugs	drug	NNS
cord-015021-pol2qm74	1019	12	with	with	IN
cord-015021-pol2qm74	1019	13	a	a	DT
cord-015021-pol2qm74	1019	14	very	very	RB
cord-015021-pol2qm74	1019	15	broad	broad	JJ
cord-015021-pol2qm74	1019	16	application	application	NN
cord-015021-pol2qm74	1019	17	under	under	IN
cord-015021-pol2qm74	1019	18	acute	acute	JJ
cord-015021-pol2qm74	1019	19	phases	phase	NNS
cord-015021-pol2qm74	1019	20	el	el	NNP
cord-015021-pol2qm74	1019	21	inflammation	inflammation	NN
cord-015021-pol2qm74	1019	22	,	,	,
cord-015021-pol2qm74	1019	23	injury	injury	NN
cord-015021-pol2qm74	1019	24	and	and	CC
cord-015021-pol2qm74	1019	25	infection	infection	NN
cord-015021-pol2qm74	1019	26	.	.	.
cord-015021-pol2qm74	1020	1	Northern	northern	JJ
cord-015021-pol2qm74	1020	2	Blot	blot	NN
cord-015021-pol2qm74	1020	3	experiments	experiment	NNS
cord-015021-pol2qm74	1020	4	revealed	reveal	VBD
cord-015021-pol2qm74	1020	5	that	that	DT
cord-015021-pol2qm74	1020	6	expression	expression	NN
cord-015021-pol2qm74	1020	7	of	of	IN
cord-015021-pol2qm74	1020	8	the	the	DT
cord-015021-pol2qm74	1020	9	recently	recently	RB
cord-015021-pol2qm74	1020	10	discovered	discover	VBN
cord-015021-pol2qm74	1020	11	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-015021-pol2qm74	1020	12	Binding	Binding	NNP
cord-015021-pol2qm74	1020	13	Protein	Protein	NNP
cord-015021-pol2qm74	1020	14	(	(	-LRB-
cord-015021-pol2qm74	1020	15	LBP	LBP	NNP
cord-015021-pol2qm74	1020	16	)	)	-RRB-
cord-015021-pol2qm74	1020	17	,	,	,
cord-015021-pol2qm74	1020	18	a	a	DT
cord-015021-pol2qm74	1020	19	58/60	58/60	CD
cord-015021-pol2qm74	1020	20	kD	kD	NNP
cord-015021-pol2qm74	1020	21	Glycoprotein	Glycoprotein	NNP
cord-015021-pol2qm74	1020	22	,	,	,
cord-015021-pol2qm74	1020	23	in	in	IN
cord-015021-pol2qm74	1020	24	the	the	DT
cord-015021-pol2qm74	1020	25	liver	liver	NN
cord-015021-pol2qm74	1020	26	rises	rise	VBZ
cord-015021-pol2qm74	1020	27	substantially	substantially	RB
cord-015021-pol2qm74	1020	28	during	during	IN
cord-015021-pol2qm74	1020	29	the	the	DT
cord-015021-pol2qm74	1020	30	acute	acute	JJ
cord-015021-pol2qm74	1020	31	phase	phase	NN
cord-015021-pol2qm74	1020	32	response	response	NN
cord-015021-pol2qm74	1020	33	.	.	.
cord-015021-pol2qm74	1021	1	Experiments	experiment	NNS
cord-015021-pol2qm74	1021	2	with	with	IN
cord-015021-pol2qm74	1021	3	an	an	DT
cord-015021-pol2qm74	1021	4	in	in	IN
cord-015021-pol2qm74	1021	5	-	-	HYPH
cord-015021-pol2qm74	1021	6	vivo	vivo	NN
cord-015021-pol2qm74	1021	7	acute	acute	JJ
cord-015021-pol2qm74	1021	8	phase	phase	NN
cord-015021-pol2qm74	1021	9	model	model	NN
cord-015021-pol2qm74	1021	10	using	use	VBG
cord-015021-pol2qm74	1021	11	New	New	NNP
cord-015021-pol2qm74	1021	12	-	-	HYPH
cord-015021-pol2qm74	1021	13	Zealand	Zealand	NNP
cord-015021-pol2qm74	1021	14	-	-	HYPH
cord-015021-pol2qm74	1021	15	White	white	JJ
cord-015021-pol2qm74	1021	16	rabbits	rabbit	NNS
cord-015021-pol2qm74	1021	17	and	and	CC
cord-015021-pol2qm74	1021	18	also	also	RB
cord-015021-pol2qm74	1021	19	in	in	IN
cord-015021-pol2qm74	1021	20	-	-	HYPH
cord-015021-pol2qm74	1021	21	vitro	vitro	FW
cord-015021-pol2qm74	1021	22	experiments	experiment	NNS
cord-015021-pol2qm74	1021	23	employing	employ	VBG
cord-015021-pol2qm74	1021	24	stimulated	stimulate	VBN
cord-015021-pol2qm74	1021	25	Hep	Hep	NNP
cord-015021-pol2qm74	1021	26	-	-	HYPH
cord-015021-pol2qm74	1021	27	G2	G2	NNP
cord-015021-pol2qm74	1021	28	cells	cell	NNS
cord-015021-pol2qm74	1021	29	showed	show	VBD
cord-015021-pol2qm74	1021	30	that	that	IN
cord-015021-pol2qm74	1021	31	LBP	LBP	NNP
cord-015021-pol2qm74	1021	32	transcripts	transcript	NNS
cord-015021-pol2qm74	1021	33	could	could	MD
cord-015021-pol2qm74	1021	34	be	be	VB
cord-015021-pol2qm74	1021	35	induced	induce	VBN
cord-015021-pol2qm74	1021	36	10	10	CD
cord-015021-pol2qm74	1021	37	to	to	TO
cord-015021-pol2qm74	1021	38	100	100	CD
cord-015021-pol2qm74	1021	39	ford	ford	NN
cord-015021-pol2qm74	1021	40	within	within	IN
cord-015021-pol2qm74	1021	41	24	24	CD
cord-015021-pol2qm74	1021	42	hours	hour	NNS
cord-015021-pol2qm74	1021	43	after	after	IN
cord-015021-pol2qm74	1021	44	induction	induction	NN
cord-015021-pol2qm74	1021	45	with	with	IN
cord-015021-pol2qm74	1021	46	cytokines	cytokine	NNS
cord-015021-pol2qm74	1021	47	.	.	.
cord-015021-pol2qm74	1022	1	By	by	IN
cord-015021-pol2qm74	1022	2	using	use	VBG
cord-015021-pol2qm74	1022	3	a	a	DT
cord-015021-pol2qm74	1022	4	newly	newly	RB
cord-015021-pol2qm74	1022	5	established	establish	VBN
cord-015021-pol2qm74	1022	6	nonradioactive	nonradioactive	JJ
cord-015021-pol2qm74	1022	7	nuclear	nuclear	JJ
cord-015021-pol2qm74	1022	8	run	run	NN
cord-015021-pol2qm74	1022	9	-	-	HYPH
cord-015021-pol2qm74	1022	10	on	on	RP
cord-015021-pol2qm74	1022	11	technique	technique	NN
cord-015021-pol2qm74	1022	12	we	-PRON-	PRP
cord-015021-pol2qm74	1022	13	show	show	VBP
cord-015021-pol2qm74	1022	14	that	that	IN
cord-015021-pol2qm74	1022	15	induction	induction	NN
cord-015021-pol2qm74	1022	16	of	of	IN
cord-015021-pol2qm74	1022	17	LBP	LBP	NNP
cord-015021-pol2qm74	1022	18	during	during	IN
cord-015021-pol2qm74	1022	19	the	the	DT
cord-015021-pol2qm74	1022	20	acute	acute	JJ
cord-015021-pol2qm74	1022	21	phase	phase	NN
cord-015021-pol2qm74	1022	22	is	be	VBZ
cord-015021-pol2qm74	1022	23	transcriptionally	transcriptionally	RB
cord-015021-pol2qm74	1022	24	regulated	regulate	VBN
cord-015021-pol2qm74	1022	25	.	.	.
cord-015021-pol2qm74	1023	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	1023	2	we	-PRON-	PRP
cord-015021-pol2qm74	1023	3	screened	screen	VBD
cord-015021-pol2qm74	1023	4	a	a	DT
cord-015021-pol2qm74	1023	5	human	human	JJ
cord-015021-pol2qm74	1023	6	genomic	genomic	JJ
cord-015021-pol2qm74	1023	7	library	library	NN
cord-015021-pol2qm74	1023	8	and	and	CC
cord-015021-pol2qm74	1023	9	were	be	VBD
cord-015021-pol2qm74	1023	10	able	able	JJ
cord-015021-pol2qm74	1023	11	to	to	TO
cord-015021-pol2qm74	1023	12	clone	clone	VB
cord-015021-pol2qm74	1023	13	the	the	DT
cord-015021-pol2qm74	1023	14	LBP	LBP	NNP
cord-015021-pol2qm74	1023	15	gone	go	VBN
cord-015021-pol2qm74	1023	16	,	,	,
cord-015021-pol2qm74	1023	17	containing	contain	VBG
cord-015021-pol2qm74	1023	18	the	the	DT
cord-015021-pol2qm74	1023	19	promoter	promoter	NN
cord-015021-pol2qm74	1023	20	1.5	1.5	CD
cord-015021-pol2qm74	1023	21	kB	kb	CD
cord-015021-pol2qm74	1023	22	upstream	upstream	RB
cord-015021-pol2qm74	1023	23	.	.	.
cord-015021-pol2qm74	1024	1	Several	several	JJ
cord-015021-pol2qm74	1024	2	liver	liver	NN
cord-015021-pol2qm74	1024	3	-	-	HYPH
cord-015021-pol2qm74	1024	4	specific	specific	JJ
cord-015021-pol2qm74	1024	5	and	and	CC
cord-015021-pol2qm74	1024	6	"	"	``
cord-015021-pol2qm74	1024	7	acute	acute	JJ
cord-015021-pol2qm74	1024	8	-	-	HYPH
cord-015021-pol2qm74	1024	9	phase	phase	NN
cord-015021-pol2qm74	1024	10	-	-	HYPH
cord-015021-pol2qm74	1024	11	typical	typical	JJ
cord-015021-pol2qm74	1024	12	"	"	``
cord-015021-pol2qm74	1024	13	potential	potential	JJ
cord-015021-pol2qm74	1024	14	binding	binding	NN
cord-015021-pol2qm74	1024	15	sites	site	NNS
cord-015021-pol2qm74	1024	16	were	be	VBD
cord-015021-pol2qm74	1024	17	found	find	VBN
cord-015021-pol2qm74	1024	18	fn	fn	NNP
cord-015021-pol2qm74	1024	19	the	the	DT
cord-015021-pol2qm74	1024	20	promoter	promoter	NN
cord-015021-pol2qm74	1024	21	region	region	NN
cord-015021-pol2qm74	1024	22	and	and	CC
cord-015021-pol2qm74	1024	23	reporter	reporter	NN
cord-015021-pol2qm74	1024	24	gone	go	VBN
cord-015021-pol2qm74	1024	25	assays	assay	NNS
cord-015021-pol2qm74	1024	26	were	be	VBD
cord-015021-pol2qm74	1024	27	set	set	VBN
cord-015021-pol2qm74	1024	28	up	up	RP
cord-015021-pol2qm74	1024	29	.	.	.
cord-015021-pol2qm74	1025	1	Several	several	JJ
cord-015021-pol2qm74	1025	2	CAAT	CAAT	NNP
cord-015021-pol2qm74	1025	3	-	-	HYPH
cord-015021-pol2qm74	1025	4	boxes	box	NNS
cord-015021-pol2qm74	1025	5	,	,	,
cord-015021-pol2qm74	1025	6	the	the	DT
cord-015021-pol2qm74	1025	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	1025	8	responsive	responsive	JJ
cord-015021-pol2qm74	1025	9	elements	element	NNS
cord-015021-pol2qm74	1025	10	HSTF	HSTF	NNP
cord-015021-pol2qm74	1025	11	-	-	HYPH
cord-015021-pol2qm74	1025	12	hsp	hsp	NNP
cord-015021-pol2qm74	1025	13	70.5	70.5	CD
cord-015021-pol2qm74	1025	14	and	and	CC
cord-015021-pol2qm74	1025	15	H	H	NNP
cord-015021-pol2qm74	1025	16	-	-	HYPH
cord-015021-pol2qm74	1025	17	APF-1	APF-1	NNP
cord-015021-pol2qm74	1025	18	RS	rs	NN
cord-015021-pol2qm74	1025	19	as	as	RB
cord-015021-pol2qm74	1025	20	well	well	RB
cord-015021-pol2qm74	1025	21	as	as	IN
cord-015021-pol2qm74	1025	22	the	the	DT
cord-015021-pol2qm74	1025	23	transcription	transcription	NN
cord-015021-pol2qm74	1025	24	factor	factor	NN
cord-015021-pol2qm74	1025	25	HNF-5	HNF-5	NNPS
cord-015021-pol2qm74	1025	26	and	and	CC
cord-015021-pol2qm74	1025	27	the	the	DT
cord-015021-pol2qm74	1025	28	glucocrticoid	glucocrticoid	JJ
cord-015021-pol2qm74	1025	29	-	-	HYPH
cord-015021-pol2qm74	1025	30	responsive	responsive	JJ
cord-015021-pol2qm74	1025	31	elements	element	NNS
cord-015021-pol2qm74	1026	1	Oct-2-D	Oct-2-D	NNP
cord-015021-pol2qm74	1026	2	and	and	CC
cord-015021-pol2qm74	1026	3	GCRE	GCRE	NNP
cord-015021-pol2qm74	1026	4	were	be	VBD
cord-015021-pol2qm74	1026	5	found	find	VBN
cord-015021-pol2qm74	1026	6	,	,	,
cord-015021-pol2qm74	1026	7	which	which	WDT
cord-015021-pol2qm74	1026	8	correlates	correlate	VBZ
cord-015021-pol2qm74	1026	9	with	with	IN
cord-015021-pol2qm74	1026	10	the	the	DT
cord-015021-pol2qm74	1026	11	induction	induction	NN
cord-015021-pol2qm74	1026	12	pattern	pattern	NN
cord-015021-pol2qm74	1026	13	of	of	IN
cord-015021-pol2qm74	1026	14	LBP	LBP	NNP
cord-015021-pol2qm74	1026	15	mRNA	mrna	NN
cord-015021-pol2qm74	1026	16	in	in	IN
cord-015021-pol2qm74	1026	17	Hep	Hep	NNP
cord-015021-pol2qm74	1026	18	-	-	HYPH
cord-015021-pol2qm74	1026	19	G2	G2	NNP
cord-015021-pol2qm74	1026	20	cells	cell	NNS
cord-015021-pol2qm74	1026	21	by	by	IN
cord-015021-pol2qm74	1026	22	IL-6	IL-6	NNP
cord-015021-pol2qm74	1026	23	,	,	,
cord-015021-pol2qm74	1026	24	IL-1	IL-1	NNP
cord-015021-pol2qm74	1026	25	and	and	CC
cord-015021-pol2qm74	1026	26	Dexamethasone	Dexamethasone	NNP
cord-015021-pol2qm74	1026	27	.	.	.
cord-015021-pol2qm74	1027	1	PCR	PCR	NNP
cord-015021-pol2qm74	1027	2	-	-	HYPH
cord-015021-pol2qm74	1027	3	based	base	VBN
cord-015021-pol2qm74	1027	4	analysis	analysis	NN
cord-015021-pol2qm74	1027	5	of	of	IN
cord-015021-pol2qm74	1027	6	the	the	DT
cord-015021-pol2qm74	1027	7	exon	exon	NN
cord-015021-pol2qm74	1027	8	-	-	HYPH
cord-015021-pol2qm74	1027	9	intron	intron	NN
cord-015021-pol2qm74	1027	10	pattern	pattern	NN
cord-015021-pol2qm74	1027	11	of	of	IN
cord-015021-pol2qm74	1027	12	the	the	DT
cord-015021-pol2qm74	1027	13	LBP	LBP	NNP
cord-015021-pol2qm74	1027	14	gene	gene	NN
cord-015021-pol2qm74	1027	15	revealed	reveal	VBD
cord-015021-pol2qm74	1027	16	similarities	similarity	NNS
cord-015021-pol2qm74	1027	17	with	with	IN
cord-015021-pol2qm74	1027	18	the	the	DT
cord-015021-pol2qm74	1027	19	genes	gene	NNS
cord-015021-pol2qm74	1027	20	of	of	IN
cord-015021-pol2qm74	1027	21	two	two	CD
cord-015021-pol2qm74	1027	22	other	other	JJ
cord-015021-pol2qm74	1027	23	LPS	lp	NNS
cord-015021-pol2qm74	1027	24	binding	binding	NN
cord-015021-pol2qm74	1027	25	proteins	protein	NNS
cord-015021-pol2qm74	1027	26	,	,	,
cord-015021-pol2qm74	1027	27	namely	namely	RB
cord-015021-pol2qm74	1027	28	BPI	BPI	NNP
cord-015021-pol2qm74	1027	29	and	and	CC
cord-015021-pol2qm74	1027	30	CETP	CETP	NNP
cord-015021-pol2qm74	1027	31	.	.	.
cord-015021-pol2qm74	1028	1	Further	further	JJ
cord-015021-pol2qm74	1028	2	analysis	analysis	NN
cord-015021-pol2qm74	1028	3	of	of	IN
cord-015021-pol2qm74	1028	4	this	this	DT
cord-015021-pol2qm74	1028	5	novel	novel	JJ
cord-015021-pol2qm74	1028	6	acute	acute	JJ
cord-015021-pol2qm74	1028	7	phase	phase	NN
cord-015021-pol2qm74	1028	8	protein	protein	NN
cord-015021-pol2qm74	1028	9	,	,	,
cord-015021-pol2qm74	1028	10	that	that	WDT
cord-015021-pol2qm74	1028	11	also	also	RB
cord-015021-pol2qm74	1028	12	has	have	VBZ
cord-015021-pol2qm74	1028	13	an	an	DT
cord-015021-pol2qm74	1028	14	important	important	JJ
cord-015021-pol2qm74	1028	15	role	role	NN
cord-015021-pol2qm74	1028	16	in	in	IN
cord-015021-pol2qm74	1028	17	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	1028	18	recognition	recognition	NN
cord-015021-pol2qm74	1028	19	and	and	CC
cord-015021-pol2qm74	1028	20	immunomodulation	immunomodulation	NN
cord-015021-pol2qm74	1028	21	will	will	MD
cord-015021-pol2qm74	1028	22	help	help	VB
cord-015021-pol2qm74	1028	23	in	in	IN
cord-015021-pol2qm74	1028	24	understanding	understand	VBG
cord-015021-pol2qm74	1028	25	the	the	DT
cord-015021-pol2qm74	1028	26	complex	complex	JJ
cord-015021-pol2qm74	1028	27	acute	acute	JJ
cord-015021-pol2qm74	1028	28	phase	phase	NN
cord-015021-pol2qm74	1028	29	mechanism	mechanism	NN
cord-015021-pol2qm74	1028	30	and	and	CC
cord-015021-pol2qm74	1028	31	potentially	potentially	RB
cord-015021-pol2qm74	1028	32	lead	lead	VB
cord-015021-pol2qm74	1028	33	the	the	DT
cord-015021-pol2qm74	1028	34	way	way	NN
cord-015021-pol2qm74	1028	35	to	to	IN
cord-015021-pol2qm74	1028	36	new	new	JJ
cord-015021-pol2qm74	1028	37	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1028	38	strategies	strategy	NNS
cord-015021-pol2qm74	1028	39	.	.	.
cord-015021-pol2qm74	1029	1	LPS	LPS	NNP
cord-015021-pol2qm74	1029	2	ACTIVATION	ACTIVATION	NNP
cord-015021-pol2qm74	1029	3	OF	of	IN
cord-015021-pol2qm74	1029	4	NUCLE?/R	NUCLE?/R	NNP
cord-015021-pol2qm74	1029	5	FA	FA	NNP
cord-015021-pol2qm74	1029	6	-	-	HYPH
cord-015021-pol2qm74	1029	7	CTOR:~B	CTOR:~B	NNP
cord-015021-pol2qm74	1029	8	"	"	''
cord-015021-pol2qm74	1030	1	(	(	-LRB-
cord-015021-pol2qm74	1030	2	NF:~BJ"IN	NF:~BJ"IN	NNP
cord-015021-pol2qm74	1030	3	 	 	_SP
cord-015021-pol2qm74	1030	4	CD14.TRANSFECTED	CD14.TRANSFECTED	NNP
cord-015021-pol2qm74	1030	5	FI'BROBLASTS	FI'BROBLASTS	NNP
cord-015021-pol2qm74	1030	6	DOES	do	VBZ
cord-015021-pol2qm74	1030	7	NOT	not	RB
cord-015021-pol2qm74	1030	8	APPEAR	appear	VB
cord-015021-pol2qm74	1030	9	 	 	_SP
cord-015021-pol2qm74	1030	10	TO	to	TO
cord-015021-pol2qm74	1030	11	REQUIRE	require	VB
cord-015021-pol2qm74	1030	12	TYROSINE	TYROSINE	NNP
cord-015021-pol2qm74	1030	13	KINASE	kinase	JJ
cord-015021-pol2qm74	1030	14	ACTIVITY	activity	NN
cord-015021-pol2qm74	1030	15	 	 	_SP
cord-015021-pol2qm74	1030	16	D.	D.	NNP
cord-015021-pol2qm74	1030	17	T.	T.	NNP
cord-015021-pol2qm74	1030	18	Golenbock	Golenbock	NNP
cord-015021-pol2qm74	1030	19	,	,	,
cord-015021-pol2qm74	1030	20	R.	R.	NNP
cord-015021-pol2qm74	1030	21	DeLude	DeLude	NNP
cord-015021-pol2qm74	1030	22	,	,	,
cord-015021-pol2qm74	1030	23	R.	R.	NNP
cord-015021-pol2qm74	1030	24	Savedra	Savedra	NNP
cord-015021-pol2qm74	1030	25	,	,	,
cord-015021-pol2qm74	1030	26	S.	S.	NNP
cord-015021-pol2qm74	1030	27	Vogel	Vogel	NNP
cord-015021-pol2qm74	1030	28	and	and	CC
cord-015021-pol2qm74	1030	29	M.	M.	NNP
cord-015021-pol2qm74	1030	30	J.	J.	NNP
cord-015021-pol2qm74	1030	31	Fenton	Fenton	NNP
cord-015021-pol2qm74	1030	32	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-015021-pol2qm74	1030	33	(	(	-LRB-
cord-015021-pol2qm74	1030	34	LPS	LPS	NNP
cord-015021-pol2qm74	1030	35	)	)	-RRB-
cord-015021-pol2qm74	1031	1	is	be	VBZ
cord-015021-pol2qm74	1031	2	the	the	DT
cord-015021-pol2qm74	1031	3	major	major	JJ
cord-015021-pol2qm74	1031	4	constituent	constituent	NN
cord-015021-pol2qm74	1031	5	of	of	IN
cord-015021-pol2qm74	1031	6	the	the	DT
cord-015021-pol2qm74	1031	7	outer	outer	JJ
cord-015021-pol2qm74	1031	8	leaflet	leaflet	NN
cord-015021-pol2qm74	1031	9	of	of	IN
cord-015021-pol2qm74	1031	10	Gram	gram	NN
cord-015021-pol2qm74	1031	11	-	-	HYPH
cord-015021-pol2qm74	1031	12	negative	negative	JJ
cord-015021-pol2qm74	1031	13	bacteria	bacteria	NNS
cord-015021-pol2qm74	1031	14	.	.	.
cord-015021-pol2qm74	1032	1	During	during	IN
cord-015021-pol2qm74	1032	2	the	the	DT
cord-015021-pol2qm74	1032	3	course	course	NN
cord-015021-pol2qm74	1032	4	of	of	IN
cord-015021-pol2qm74	1032	5	serious	serious	JJ
cord-015021-pol2qm74	1032	6	infection	infection	NN
cord-015021-pol2qm74	1032	7	,	,	,
cord-015021-pol2qm74	1032	8	shock	shock	NN
cord-015021-pol2qm74	1032	9	may	may	MD
cord-015021-pol2qm74	1032	10	occur	occur	VB
cord-015021-pol2qm74	1032	11	as	as	IN
cord-015021-pol2qm74	1032	12	a	a	DT
cord-015021-pol2qm74	1032	13	result	result	NN
cord-015021-pol2qm74	1032	14	of	of	IN
cord-015021-pol2qm74	1032	15	the	the	DT
cord-015021-pol2qm74	1032	16	interaction	interaction	NN
cord-015021-pol2qm74	1032	17	of	of	IN
cord-015021-pol2qm74	1032	18	LPS	LPS	NNP
cord-015021-pol2qm74	1032	19	with	with	IN
cord-015021-pol2qm74	1032	20	macrophage	macrophage	NN
cord-015021-pol2qm74	1032	21	LPS	LPS	NNP
cord-015021-pol2qm74	1032	22	receptors	receptor	NNS
cord-015021-pol2qm74	1032	23	.	.	.
cord-015021-pol2qm74	1033	1	CD14	CD14	NNP
cord-015021-pol2qm74	1033	2	,	,	,
cord-015021-pol2qm74	1033	3	a	a	DT
cord-015021-pol2qm74	1033	4	55	55	CD
cord-015021-pol2qm74	1033	5	kDa	kDa	NNS
cord-015021-pol2qm74	1033	6	glycosyl	glycosyl	NN
cord-015021-pol2qm74	1033	7	phosphatidylinositol	phosphatidylinositol	NN
cord-015021-pol2qm74	1033	8	(	(	-LRB-
cord-015021-pol2qm74	1033	9	GPI)-linked	GPI)-linked	NNP
cord-015021-pol2qm74	1033	10	protein	protein	NN
cord-015021-pol2qm74	1033	11	,	,	,
cord-015021-pol2qm74	1033	12	functions	function	VBZ
cord-015021-pol2qm74	1033	13	as	as	IN
cord-015021-pol2qm74	1033	14	an	an	DT
cord-015021-pol2qm74	1033	15	LPS	LPS	NNP
cord-015021-pol2qm74	1033	16	receptor	receptor	NN
cord-015021-pol2qm74	1033	17	.	.	.
cord-015021-pol2qm74	1034	1	A	a	DT
cord-015021-pol2qm74	1034	2	critical	critical	JJ
cord-015021-pol2qm74	1034	3	issue	issue	NN
cord-015021-pol2qm74	1034	4	in	in	IN
cord-015021-pol2qm74	1034	5	LPS	LPS	NNP
cord-015021-pol2qm74	1034	6	activation	activation	NN
cord-015021-pol2qm74	1034	7	concerns	concern	VBZ
cord-015021-pol2qm74	1034	8	the	the	DT
cord-015021-pol2qm74	1034	9	mechanism	mechanism	NN
cord-015021-pol2qm74	1034	10	by	by	IN
cord-015021-pol2qm74	1034	11	which	which	WDT
cord-015021-pol2qm74	1034	12	CD14	CD14	NNP
cord-015021-pol2qm74	1034	13	,	,	,
cord-015021-pol2qm74	1034	14	which	which	WDT
cord-015021-pol2qm74	1034	15	has	have	VBZ
cord-015021-pol2qm74	1034	16	no	no	DT
cord-015021-pol2qm74	1034	17	transmernbrane	transmernbrane	NNP
cord-015021-pol2qm74	1034	18	domain	domain	NN
cord-015021-pol2qm74	1034	19	,	,	,
cord-015021-pol2qm74	1034	20	transduces	transduce	VBZ
cord-015021-pol2qm74	1034	21	a	a	DT
cord-015021-pol2qm74	1034	22	sig	sig	NN
cord-015021-pol2qm74	1034	23	,	,	,
cord-015021-pol2qm74	1034	24	nal	nal	JJ
cord-015021-pol2qm74	1034	25	after	after	IN
cord-015021-pol2qm74	1034	26	LPS	LPS	NNP
cord-015021-pol2qm74	1034	27	binding	bind	VBG
cord-015021-pol2qm74	1034	28	.	.	.
cord-015021-pol2qm74	1035	1	Evidence	evidence	NN
cord-015021-pol2qm74	1035	2	exists	exist	VBZ
cord-015021-pol2qm74	1035	3	which	which	WDT
cord-015021-pol2qm74	1035	4	suggests	suggest	VBZ
cord-015021-pol2qm74	1035	5	that	that	IN
cord-015021-pol2qm74	1035	6	CD14	CD14	NNP
cord-015021-pol2qm74	1035	7	may	may	MD
cord-015021-pol2qm74	1035	8	signal	signal	VB
cord-015021-pol2qm74	1035	9	cells	cell	NNS
cord-015021-pol2qm74	1035	10	after	after	IN
cord-015021-pol2qm74	1035	11	LPS	lp	NNS
cord-015021-pol2qm74	1035	12	binding	bind	VBG
cord-015021-pol2qm74	1035	13	by	by	IN
cord-015021-pol2qm74	1035	14	interacting	interact	VBG
cord-015021-pol2qm74	1035	15	with	with	IN
cord-015021-pol2qm74	1035	16	an	an	DT
cord-015021-pol2qm74	1035	17	LPS	LPS	NNP
cord-015021-pol2qm74	1035	18	signal	signal	NN
cord-015021-pol2qm74	1035	19	transducer	transducer	NN
cord-015021-pol2qm74	1035	20	with	with	IN
cord-015021-pol2qm74	1035	21	tyrosine	tyrosine	NN
cord-015021-pol2qm74	1035	22	kinase	kinase	NN
cord-015021-pol2qm74	1035	23	(	(	-LRB-
cord-015021-pol2qm74	1035	24	TK	TK	NNP
cord-015021-pol2qm74	1035	25	)	)	-RRB-
cord-015021-pol2qm74	1035	26	activity	activity	NN
cord-015021-pol2qm74	1035	27	.	.	.
cord-015021-pol2qm74	1036	1	Wild	wild	JJ
cord-015021-pol2qm74	1036	2	-	-	HYPH
cord-015021-pol2qm74	1036	3	type	type	NN
cord-015021-pol2qm74	1036	4	Chinese	chinese	JJ
cord-015021-pol2qm74	1036	5	Hamster	Hamster	NNP
cord-015021-pol2qm74	1036	6	Ovary	Ovary	NNP
cord-015021-pol2qm74	1036	7	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	1036	8	(	(	-LRB-
cord-015021-pol2qm74	1036	9	CHO	CHO	NNP
cord-015021-pol2qm74	1036	10	)	)	-RRB-
cord-015021-pol2qm74	1036	11	normally	normally	RB
cord-015021-pol2qm74	1036	12	do	do	VBP
cord-015021-pol2qm74	1036	13	not	not	RB
cord-015021-pol2qm74	1036	14	respond	respond	VB
cord-015021-pol2qm74	1036	15	to	to	IN
cord-015021-pol2qm74	1036	16	LPS	LPS	NNP
cord-015021-pol2qm74	1036	17	,	,	,
cord-015021-pol2qm74	1036	18	but	but	CC
cord-015021-pol2qm74	1036	19	can	can	MD
cord-015021-pol2qm74	1036	20	be	be	VB
cord-015021-pol2qm74	1036	21	activated	activate	VBN
cord-015021-pol2qm74	1036	22	following	follow	VBG
cord-015021-pol2qm74	1036	23	transfection	transfection	NN
cord-015021-pol2qm74	1036	24	with	with	IN
cord-015021-pol2qm74	1036	25	CD14	CD14	NNP
cord-015021-pol2qm74	1036	26	(	(	-LRB-
cord-015021-pol2qm74	1036	27	CHO	CHO	NNP
cord-015021-pol2qm74	1036	28	/	/	SYM
cord-015021-pol2qm74	1036	29	CD14	CD14	NNP
cord-015021-pol2qm74	1036	30	)	)	-RRB-
cord-015021-pol2qm74	1036	31	.	.	.
cord-015021-pol2qm74	1037	1	Stimulation	stimulation	NN
cord-015021-pol2qm74	1037	2	of	of	IN
cord-015021-pol2qm74	1037	3	CHO	CHO	NNP
cord-015021-pol2qm74	1037	4	/	/	SYM
cord-015021-pol2qm74	1037	5	CDI4	CDI4	NNP
cord-015021-pol2qm74	1037	6	with	with	IN
cord-015021-pol2qm74	1037	7	as	as	RB
cord-015021-pol2qm74	1037	8	little	little	JJ
cord-015021-pol2qm74	1037	9	as	as	IN
cord-015021-pol2qm74	1037	10	1	1	CD
cord-015021-pol2qm74	1037	11	ng	ng	NN
cord-015021-pol2qm74	1037	12	of	of	IN
cord-015021-pol2qm74	1037	13	LPS	LPS	NNP
cord-015021-pol2qm74	1037	14	/	/	SYM
cord-015021-pol2qm74	1037	15	ml	ml	NNS
cord-015021-pol2qm74	1037	16	resulted	result	VBD
cord-015021-pol2qm74	1037	17	in	in	IN
cord-015021-pol2qm74	1037	18	the	the	DT
cord-015021-pol2qm74	1037	19	release	release	NN
cord-015021-pol2qm74	1037	20	of	of	IN
cord-015021-pol2qm74	1037	21	3H	3h	CD
cord-015021-pol2qm74	1037	22	-	-	HYPH
cord-015021-pol2qm74	1037	23	arachidonic	arachidonic	NN
cord-015021-pol2qm74	1037	24	acid	acid	NN
cord-015021-pol2qm74	1037	25	(	(	-LRB-
cord-015021-pol2qm74	1037	26	3H-20:4	3h-20:4	CD
cord-015021-pol2qm74	1037	27	)	)	-RRB-
cord-015021-pol2qm74	1037	28	into	into	IN
cord-015021-pol2qm74	1037	29	the	the	DT
cord-015021-pol2qm74	1037	30	culture	culture	NN
cord-015021-pol2qm74	1037	31	supernatant	supernatant	JJ
cord-015021-pol2qm74	1037	32	.	.	.
cord-015021-pol2qm74	1038	1	In	in	IN
cord-015021-pol2qm74	1038	2	addition	addition	NN
cord-015021-pol2qm74	1038	3	to	to	IN
cord-015021-pol2qm74	1038	4	3H-20:4	3h-20:4	CD
cord-015021-pol2qm74	1038	5	release	release	NN
cord-015021-pol2qm74	1038	6	,	,	,
cord-015021-pol2qm74	1038	7	we	-PRON-	PRP
cord-015021-pol2qm74	1038	8	examined	examine	VBD
cord-015021-pol2qm74	1038	9	LPS	LPS	NNP
cord-015021-pol2qm74	1038	10	-	-	HYPH
cord-015021-pol2qm74	1038	11	imiuced	imiuced	JJ
cord-015021-pol2qm74	1038	12	activation	activation	NN
cord-015021-pol2qm74	1038	13	(	(	-LRB-
cord-015021-pol2qm74	1038	14	transl0cation	transl0cation	NNP
cord-015021-pol2qm74	1038	15	)	)	-RRB-
cord-015021-pol2qm74	1038	16	of	of	IN
cord-015021-pol2qm74	1038	17	the	the	DT
cord-015021-pol2qm74	1038	18	transcription	transcription	NN
cord-015021-pol2qm74	1038	19	factor	factor	NN
cord-015021-pol2qm74	1039	1	NF-~B.	NF-~B.	NNP
cord-015021-pol2qm74	1039	2	Similar	Similar	NNP
cord-015021-pol2qm74	1039	3	to	to	IN
cord-015021-pol2qm74	1039	4	LPS	LPS	NNP
cord-015021-pol2qm74	1039	5	-	-	HYPH
cord-015021-pol2qm74	1039	6	induced	induce	VBN
cord-015021-pol2qm74	1039	7	3H-20:4	3h-20:4	CD
cord-015021-pol2qm74	1039	8	release	release	NN
cord-015021-pol2qm74	1040	1	,	,	,
cord-015021-pol2qm74	1040	2	these	these	DT
cord-015021-pol2qm74	1040	3	responses	response	NNS
cord-015021-pol2qm74	1040	4	were	be	VBD
cord-015021-pol2qm74	1040	5	observed	observe	VBN
cord-015021-pol2qm74	1040	6	only	only	RB
cord-015021-pol2qm74	1040	7	in	in	IN
cord-015021-pol2qm74	1040	8	CHO	CHO	NNP
cord-015021-pol2qm74	1040	9	cells	cell	NNS
cord-015021-pol2qm74	1040	10	lransfected	lransfecte	VBN
cord-015021-pol2qm74	1040	11	with	with	IN
cord-015021-pol2qm74	1040	12	CD14	CD14	NNP
cord-015021-pol2qm74	1040	13	closely	closely	RB
cord-015021-pol2qm74	1040	14	resembling	resemble	VBG
cord-015021-pol2qm74	1040	15	the	the	DT
cord-015021-pol2qm74	1040	16	same	same	JJ
cord-015021-pol2qm74	1040	17	response	response	NN
cord-015021-pol2qm74	1040	18	in	in	IN
cord-015021-pol2qm74	1040	19	the	the	DT
cord-015021-pol2qm74	1040	20	marine	marine	JJ
cord-015021-pol2qm74	1040	21	macrophage	macrophage	NN
cord-015021-pol2qm74	1040	22	cell	cell	NN
cord-015021-pol2qm74	1040	23	line	line	NN
cord-015021-pol2qm74	1040	24	RAW	raw	JJ
cord-015021-pol2qm74	1040	25	264.7	264.7	CD
cord-015021-pol2qm74	1040	26	.	.	.
cord-015021-pol2qm74	1041	1	Maximum	maximum	JJ
cord-015021-pol2qm74	1041	2	NF-~cB	nf-~cb	JJ
cord-015021-pol2qm74	1041	3	expression	expression	NN
cord-015021-pol2qm74	1041	4	occurred	occur	VBD
cord-015021-pol2qm74	1041	5	at	at	IN
cord-015021-pol2qm74	1041	6	30	30	CD
cord-015021-pol2qm74	1041	7	minutes	minute	NNS
cord-015021-pol2qm74	1041	8	.	.	.
cord-015021-pol2qm74	1042	1	In	in	IN
cord-015021-pol2qm74	1042	2	contrast	contrast	NN
cord-015021-pol2qm74	1042	3	to	to	IN
cord-015021-pol2qm74	1042	4	LPS	LPS	NNP
cord-015021-pol2qm74	1042	5	-	-	HYPH
cord-015021-pol2qm74	1042	6	induced	induce	VBN
cord-015021-pol2qm74	1042	7	3H-20:4	3h-20:4	CD
cord-015021-pol2qm74	1042	8	release	release	NN
cord-015021-pol2qm74	1042	9	,	,	,
cord-015021-pol2qm74	1042	10	dexamethasone	dexamethasone	NN
cord-015021-pol2qm74	1042	11	,	,	,
cord-015021-pol2qm74	1042	12	cycloheximide	cycloheximide	NN
cord-015021-pol2qm74	1042	13	,	,	,
cord-015021-pol2qm74	1042	14	and	and	CC
cord-015021-pol2qm74	1042	15	actinomycin	actinomycin	NNS
cord-015021-pol2qm74	1042	16	D	D	NNP
cord-015021-pol2qm74	1042	17	had	have	VBD
cord-015021-pol2qm74	1042	18	no	no	DT
cord-015021-pol2qm74	1042	19	effect	effect	NN
cord-015021-pol2qm74	1042	20	on	on	IN
cord-015021-pol2qm74	1042	21	activation	activation	NN
cord-015021-pol2qm74	1042	22	of	of	IN
cord-015021-pol2qm74	1042	23	NF	nf	NN
cord-015021-pol2qm74	1042	24	-	-	HYPH
cord-015021-pol2qm74	1042	25	r	r	NN
cord-015021-pol2qm74	1042	26	,	,	,
cord-015021-pol2qm74	1042	27	.	.	.
cord-015021-pol2qm74	1043	1	B	B	NNP
cord-015021-pol2qm74	1043	2	in	in	IN
cord-015021-pol2qm74	1043	3	CHO	CHO	NNP
cord-015021-pol2qm74	1043	4	/	/	SYM
cord-015021-pol2qm74	1043	5	CD14	CD14	NNP
cord-015021-pol2qm74	1043	6	,	,	,
cord-015021-pol2qm74	1043	7	suggesting	suggest	VBG
cord-015021-pol2qm74	1043	8	that	that	IN
cord-015021-pol2qm74	1043	9	NF	nf	NN
cord-015021-pol2qm74	1043	10	-	-	HYPH
cord-015021-pol2qm74	1043	11	r	r	NN
cord-015021-pol2qm74	1043	12	,	,	,
cord-015021-pol2qm74	1043	13	B	b	NN
cord-015021-pol2qm74	1043	14	activation	activation	NN
cord-015021-pol2qm74	1043	15	begins	begin	VBZ
cord-015021-pol2qm74	1043	16	early	early	RB
cord-015021-pol2qm74	1043	17	after	after	IN
cord-015021-pol2qm74	1043	18	LPS	lp	NNS
cord-015021-pol2qm74	1043	19	binding	bind	VBG
cord-015021-pol2qm74	1043	20	to	to	IN
cord-015021-pol2qm74	1043	21	CD14	CD14	NNP
cord-015021-pol2qm74	1043	22	and	and	CC
cord-015021-pol2qm74	1043	23	does	do	VBZ
cord-015021-pol2qm74	1043	24	not	not	RB
cord-015021-pol2qm74	1043	25	require	require	VB
cord-015021-pol2qm74	1043	26	transcription	transcription	NN
cord-015021-pol2qm74	1043	27	or	or	CC
cord-015021-pol2qm74	1043	28	translation	translation	NN
cord-015021-pol2qm74	1043	29	.	.	.
cord-015021-pol2qm74	1044	1	We	-PRON-	PRP
cord-015021-pol2qm74	1044	2	then	then	RB
cord-015021-pol2qm74	1044	3	examined	examine	VBD
cord-015021-pol2qm74	1044	4	cells	cell	NNS
cord-015021-pol2qm74	1044	5	for	for	IN
cord-015021-pol2qm74	1044	6	LPS	LPS	NNP
cord-015021-pol2qm74	1044	7	-	-	HYPH
cord-015021-pol2qm74	1044	8	induced	induce	VBN
cord-015021-pol2qm74	1044	9	TK	TK	NNP
cord-015021-pol2qm74	1044	10	activity	activity	NN
cord-015021-pol2qm74	1044	11	by	by	IN
cord-015021-pol2qm74	1044	12	Western	western	JJ
cord-015021-pol2qm74	1044	13	blotting	blot	VBG
cord-015021-pol2qm74	1044	14	cellular	cellular	JJ
cord-015021-pol2qm74	1044	15	ly	ly	XX
cord-015021-pol2qm74	1044	16	~	~	NFP
cord-015021-pol2qm74	1044	17	ates	ates	NNP
cord-015021-pol2qm74	1044	18	with	with	IN
cord-015021-pol2qm74	1044	19	anti	anti	NNS
cord-015021-pol2qm74	1044	20	-	-	NNS
cord-015021-pol2qm74	1044	21	phcsphot-'rosin:~	phcsphot-'rosin:~	NNS
cord-015021-pol2qm74	1044	22	anl',bodie~	anl',bodie~	NNP
cord-015021-pol2qm74	1044	23	"	"	''
cord-015021-pol2qm74	1045	1	Although	although	IN
cord-015021-pol2qm74	1045	2	TK	TK	NNP
cord-015021-pol2qm74	1045	3	activity	activity	NN
cord-015021-pol2qm74	1045	4	was	be	VBD
cord-015021-pol2qm74	1045	5	seen	see	VBN
cord-015021-pol2qm74	1045	6	in	in	IN
cord-015021-pol2qm74	1045	7	LPS	LPS	NNP
cord-015021-pol2qm74	1045	8	-	-	HYPH
cord-015021-pol2qm74	1045	9	stimulated	stimulate	VBN
cord-015021-pol2qm74	1045	10	RAW	raw	JJ
cord-015021-pol2qm74	1045	11	cells	cell	NNS
cord-015021-pol2qm74	1045	12	and	and	CC
cord-015021-pol2qm74	1045	13	phorbol	phorbol	NNP
cord-015021-pol2qm74	1045	14	ester	ester	NNP
cord-015021-pol2qm74	1045	15	stimulated	stimulate	VBD
cord-015021-pol2qm74	1045	16	CHO	CHO	NNP
cord-015021-pol2qm74	1045	17	/	/	SYM
cord-015021-pol2qm74	1045	18	CD14	CD14	NNP
cord-015021-pol2qm74	1045	19	,	,	,
cord-015021-pol2qm74	1045	20	LPS	LPS	NNP
cord-015021-pol2qm74	1045	21	-	-	HYPH
cord-015021-pol2qm74	1045	22	induced	induce	VBN
cord-015021-pol2qm74	1045	23	TK	TK	NNP
cord-015021-pol2qm74	1045	24	activity	activity	NN
cord-015021-pol2qm74	1045	25	in	in	IN
cord-015021-pol2qm74	1045	26	CHO	CHO	NNP
cord-015021-pol2qm74	1045	27	/	/	SYM
cord-015021-pol2qm74	1045	28	CD14	CD14	NNP
cord-015021-pol2qm74	1045	29	was	be	VBD
cord-015021-pol2qm74	1045	30	not	not	RB
cord-015021-pol2qm74	1045	31	observed	observe	VBN
cord-015021-pol2qm74	1045	32	.	.	.
cord-015021-pol2qm74	1046	1	Although	although	IN
cord-015021-pol2qm74	1046	2	the	the	DT
cord-015021-pol2qm74	1046	3	TK	TK	NNP
cord-015021-pol2qm74	1046	4	inhibitor	inhibitor	NN
cord-015021-pol2qm74	1046	5	herbimycin	herbimycin	NNP
cord-015021-pol2qm74	1046	6	inhibited	inhibit	VBD
cord-015021-pol2qm74	1046	7	the	the	DT
cord-015021-pol2qm74	1046	8	release	release	NN
cord-015021-pol2qm74	1046	9	of	of	IN
cord-015021-pol2qm74	1046	10	3H-20:4	3h-20:4	CD
cord-015021-pol2qm74	1046	11	in	in	IN
cord-015021-pol2qm74	1046	12	CHO	CHO	NNP
cord-015021-pol2qm74	1046	13	/	/	SYM
cord-015021-pol2qm74	1046	14	CD14	CD14	NNP
cord-015021-pol2qm74	1046	15	and	and	CC
cord-015021-pol2qm74	1046	16	RAW	raw	JJ
cord-015021-pol2qm74	1046	17	cells	cell	NNS
cord-015021-pol2qm74	1046	18	,	,	,
cord-015021-pol2qm74	1046	19	neither	neither	CC
cord-015021-pol2qm74	1046	20	herbimycin	herbimycin	NN
cord-015021-pol2qm74	1046	21	nor	nor	CC
cord-015021-pol2qm74	1046	22	genestein	genestein	NNP
cord-015021-pol2qm74	1046	23	effectively	effectively	RB
cord-015021-pol2qm74	1046	24	blocked	block	VBD
cord-015021-pol2qm74	1046	25	NF	NF	NNP
cord-015021-pol2qm74	1046	26	-	-	HYPH
cord-015021-pol2qm74	1046	27	r	r	NN
cord-015021-pol2qm74	1046	28	,	,	,
cord-015021-pol2qm74	1046	29	B	b	NN
cord-015021-pol2qm74	1046	30	activation	activation	NN
cord-015021-pol2qm74	1046	31	in	in	IN
cord-015021-pol2qm74	1046	32	either	either	DT
cord-015021-pol2qm74	1046	33	cell	cell	NN
cord-015021-pol2qm74	1046	34	type	type	NN
cord-015021-pol2qm74	1046	35	.	.	.
cord-015021-pol2qm74	1047	1	These	these	DT
cord-015021-pol2qm74	1047	2	results	result	NNS
cord-015021-pol2qm74	1047	3	suggest	suggest	VBP
cord-015021-pol2qm74	1047	4	that	that	IN
cord-015021-pol2qm74	1047	5	TK	TK	NNP
cord-015021-pol2qm74	1047	6	activity	activity	NN
cord-015021-pol2qm74	1047	7	is	be	VBZ
cord-015021-pol2qm74	1047	8	involved	involve	VBN
cord-015021-pol2qm74	1047	9	in	in	IN
cord-015021-pol2qm74	1047	10	a	a	DT
cord-015021-pol2qm74	1047	11	portion	portion	NN
cord-015021-pol2qm74	1047	12	of	of	IN
cord-015021-pol2qm74	1047	13	the	the	DT
cord-015021-pol2qm74	1047	14	signaling	signal	VBG
cord-015021-pol2qm74	1047	15	pathway	pathway	NN
cord-015021-pol2qm74	1047	16	that	that	WDT
cord-015021-pol2qm74	1047	17	is	be	VBZ
cord-015021-pol2qm74	1047	18	distal	distal	JJ
cord-015021-pol2qm74	1047	19	to	to	IN
cord-015021-pol2qm74	1047	20	initial	initial	JJ
cord-015021-pol2qm74	1047	21	signal	signal	NN
cord-015021-pol2qm74	1047	22	transduction	transduction	NN
cord-015021-pol2qm74	1047	23	.	.	.
cord-015021-pol2qm74	1048	1	The	the	DT
cord-015021-pol2qm74	1048	2	absence	absence	NN
cord-015021-pol2qm74	1048	3	of	of	IN
cord-015021-pol2qm74	1048	4	observable	observable	JJ
cord-015021-pol2qm74	1048	5	LPS	LPS	NNP
cord-015021-pol2qm74	1048	6	-	-	HYPH
cord-015021-pol2qm74	1048	7	induced	induce	VBN
cord-015021-pol2qm74	1048	8	phosphotyrosine	phosphotyrosine	NN
cord-015021-pol2qm74	1048	9	residues	residue	NNS
cord-015021-pol2qm74	1048	10	in	in	IN
cord-015021-pol2qm74	1048	11	CHO	CHO	NNP
cord-015021-pol2qm74	1048	12	/	/	SYM
cord-015021-pol2qm74	1048	13	CD14	CD14	NNP
cord-015021-pol2qm74	1048	14	cells	cell	NNS
cord-015021-pol2qm74	1048	15	as	as	RB
cord-015021-pol2qm74	1048	16	well	well	RB
cord-015021-pol2qm74	1048	17	as	as	IN
cord-015021-pol2qm74	1048	18	the	the	DT
cord-015021-pol2qm74	1048	19	failure	failure	NN
cord-015021-pol2qm74	1048	20	of	of	IN
cord-015021-pol2qm74	1048	21	TK	TK	NNP
cord-015021-pol2qm74	1048	22	antagonists	antagonist	NNS
cord-015021-pol2qm74	1048	23	to	to	TO
cord-015021-pol2qm74	1048	24	inhibit	inhibit	VB
cord-015021-pol2qm74	1048	25	LPS	LPS	NNP
cord-015021-pol2qm74	1048	26	-	-	HYPH
cord-015021-pol2qm74	1048	27	induced	induce	VBN
cord-015021-pol2qm74	1048	28	NF-~cB	nf-~cb	JJ
cord-015021-pol2qm74	1048	29	activation	activation	NN
cord-015021-pol2qm74	1048	30	suggest	suggest	VBP
cord-015021-pol2qm74	1048	31	that	that	IN
cord-015021-pol2qm74	1048	32	the	the	DT
cord-015021-pol2qm74	1048	33	proposed	propose	VBN
cord-015021-pol2qm74	1048	34	CD14-related	CD14-related	NNP
cord-015021-pol2qm74	1048	35	LPS	LPS	NNP
cord-015021-pol2qm74	1048	36	signal	signal	NN
cord-015021-pol2qm74	1048	37	transducer	transducer	NN
cord-015021-pol2qm74	1048	38	in	in	IN
cord-015021-pol2qm74	1048	39	CHO	CHO	NNP
cord-015021-pol2qm74	1048	40	/	/	SYM
cord-015021-pol2qm74	1048	41	CD14	CD14	NNP
cord-015021-pol2qm74	1048	42	is	be	VBZ
cord-015021-pol2qm74	1048	43	not	not	RB
cord-015021-pol2qm74	1048	44	a	a	DT
cord-015021-pol2qm74	1048	45	tymsine	tymsine	NNP
cord-015021-pol2qm74	1048	46	ldnase	ldnase	NN
cord-015021-pol2qm74	1048	47	.	.	.
cord-015021-pol2qm74	1049	1	Dimished	dimished	JJ
cord-015021-pol2qm74	1049	2	cardiac	cardiac	NN
cord-015021-pol2qm74	1049	3	inotropic	inotropic	NN
cord-015021-pol2qm74	1049	4	function	function	NN
cord-015021-pol2qm74	1049	5	and	and	CC
cord-015021-pol2qm74	1049	6	response	response	NN
cord-015021-pol2qm74	1049	7	to	to	IN
cord-015021-pol2qm74	1049	8	13-adrenergic	13-adrenergic	CD
cord-015021-pol2qm74	1049	9	receptor	receptor	NN
cord-015021-pol2qm74	1049	10	(	(	-LRB-
cord-015021-pol2qm74	1049	11	13-AR	13-ar	CD
cord-015021-pol2qm74	1049	12	)	)	-RRB-
cord-015021-pol2qm74	1049	13	stimulation	stimulation	NN
cord-015021-pol2qm74	1049	14	are	be	VBP
cord-015021-pol2qm74	1049	15	frequently	frequently	RB
cord-015021-pol2qm74	1049	16	seen	see	VBN
cord-015021-pol2qm74	1049	17	in	in	IN
cord-015021-pol2qm74	1049	18	septic	septic	JJ
cord-015021-pol2qm74	1049	19	patients	patient	NNS
cord-015021-pol2qm74	1049	20	,	,	,
cord-015021-pol2qm74	1049	21	These	these	DT
cord-015021-pol2qm74	1049	22	cardiac	cardiac	JJ
cord-015021-pol2qm74	1049	23	defects	defect	NNS
cord-015021-pol2qm74	1049	24	are	be	VBP
cord-015021-pol2qm74	1049	25	also	also	RB
cord-015021-pol2qm74	1049	26	seen	see	VBN
cord-015021-pol2qm74	1049	27	in	in	IN
cord-015021-pol2qm74	1049	28	animal	animal	NN
cord-015021-pol2qm74	1049	29	models	model	NNS
cord-015021-pol2qm74	1049	30	of	of	IN
cord-015021-pol2qm74	1049	31	entoxemia	entoxemia	NNP
cord-015021-pol2qm74	1049	32	.	.	.
cord-015021-pol2qm74	1050	1	To	to	TO
cord-015021-pol2qm74	1050	2	determine	determine	VB
cord-015021-pol2qm74	1050	3	the	the	DT
cord-015021-pol2qm74	1050	4	characteristics	characteristic	NNS
cord-015021-pol2qm74	1050	5	of	of	IN
cord-015021-pol2qm74	1050	6	the	the	DT
cord-015021-pol2qm74	1050	7	decreased	decrease	VBN
cord-015021-pol2qm74	1050	8	transmembrane	transmembrane	NN
cord-015021-pol2qm74	1050	9	signal	signal	NN
cord-015021-pol2qm74	1050	10	associated	associate	VBN
cord-015021-pol2qm74	1050	11	with	with	IN
cord-015021-pol2qm74	1050	12	the	the	DT
cord-015021-pol2qm74	1050	13	decreased	decrease	VBN
cord-015021-pol2qm74	1050	14	beta	beta	JJ
cord-015021-pol2qm74	1050	15	adrenergic	adrenergic	JJ
cord-015021-pol2qm74	1050	16	response	response	NN
cord-015021-pol2qm74	1050	17	we	-PRON-	PRP
cord-015021-pol2qm74	1050	18	measured	measure	VBD
cord-015021-pol2qm74	1050	19	the	the	DT
cord-015021-pol2qm74	1050	20	force	force	NN
cord-015021-pol2qm74	1050	21	and	and	CC
cord-015021-pol2qm74	1050	22	rate	rate	NN
cord-015021-pol2qm74	1050	23	of	of	IN
cord-015021-pol2qm74	1050	24	contraction	contraction	NN
cord-015021-pol2qm74	1050	25	of	of	IN
cord-015021-pol2qm74	1050	26	atria	atria	NN
cord-015021-pol2qm74	1050	27	harvested	harvest	VBN
cord-015021-pol2qm74	1050	28	from	from	IN
cord-015021-pol2qm74	1050	29	Sprague	Sprague	NNP
cord-015021-pol2qm74	1050	30	-	-	HYPH
cord-015021-pol2qm74	1050	31	Dawley	Dawley	NNP
cord-015021-pol2qm74	1050	32	rats	rat	NNS
cord-015021-pol2qm74	1050	33	exposed	expose	VBN
cord-015021-pol2qm74	1050	34	to	to	IN
cord-015021-pol2qm74	1050	35	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1050	36	(	(	-LRB-
cord-015021-pol2qm74	1050	37	0:2	0:2	CD
cord-015021-pol2qm74	1050	38	gm	gm	NNP
cord-015021-pol2qm74	1050	39	/	/	SYM
cord-015021-pol2qm74	1050	40	kg	kg	NNP
cord-015021-pol2qm74	1050	41	)	)	-RRB-
cord-015021-pol2qm74	1050	42	.	.	.
cord-015021-pol2qm74	1051	1	To	to	TO
cord-015021-pol2qm74	1051	2	stimulate	stimulate	VB
cord-015021-pol2qm74	1051	3	various	various	JJ
cord-015021-pol2qm74	1051	4	components	component	NNS
cord-015021-pol2qm74	1051	5	of	of	IN
cord-015021-pol2qm74	1051	6	the	the	DT
cord-015021-pol2qm74	1051	7	transmembrane	transmembrane	NNP
cord-015021-pol2qm74	1051	8	signal	signal	NN
cord-015021-pol2qm74	1051	9	cascade	cascade	NN
cord-015021-pol2qm74	1051	10	of	of	IN
cord-015021-pol2qm74	1051	11	15-AR	15-ar	CD
cord-015021-pol2qm74	1051	12	was	be	VBD
cord-015021-pol2qm74	1051	13	isoproterenol	isoproterenol	NNP
cord-015021-pol2qm74	1051	14	(	(	-LRB-
cord-015021-pol2qm74	1051	15	I3-AR	i3-ar	CD
cord-015021-pol2qm74	1051	16	)	)	-RRB-
cord-015021-pol2qm74	1051	17	,	,	,
cord-015021-pol2qm74	1051	18	acetylcholine	acetylcholine	NN
cord-015021-pol2qm74	1051	19	(	(	-LRB-
cord-015021-pol2qm74	1051	20	M2ACH	M2ACH	NNP
cord-015021-pol2qm74	1051	21	receptor	receptor	NN
cord-015021-pol2qm74	1051	22	)	)	-RRB-
cord-015021-pol2qm74	1051	23	,	,	.
cord-015021-pol2qm74	1052	1	NaF(Gs	NaF(Gs	NNP
cord-015021-pol2qm74	1052	2	and	and	CC
cord-015021-pol2qm74	1052	3	Gi	Gi	NNP
cord-015021-pol2qm74	1052	4	proteins	protein	NNS
cord-015021-pol2qm74	1052	5	)	)	-RRB-
cord-015021-pol2qm74	1052	6	,	,	,
cord-015021-pol2qm74	1052	7	forskolin	forskolin	NN
cord-015021-pol2qm74	1052	8	(	(	-LRB-
cord-015021-pol2qm74	1052	9	adenylate	adenylate	NN
cord-015021-pol2qm74	1052	10	cyclase	cyclase	NN
cord-015021-pol2qm74	1052	11	)	)	-RRB-
cord-015021-pol2qm74	1052	12	,	,	,
cord-015021-pol2qm74	1052	13	and	and	CC
cord-015021-pol2qm74	1052	14	calcium	calcium	NN
cord-015021-pol2qm74	1052	15	(	(	-LRB-
cord-015021-pol2qm74	1052	16	intracellular	intracellular	JJ
cord-015021-pol2qm74	1052	17	contracttile	contracttile	NN
cord-015021-pol2qm74	1052	18	signal	signal	NN
cord-015021-pol2qm74	1052	19	)	)	-RRB-
cord-015021-pol2qm74	1052	20	were	be	VBD
cord-015021-pol2qm74	1052	21	used	use	VBN
cord-015021-pol2qm74	1052	22	.	.	.
cord-015021-pol2qm74	1053	1	To	to	TO
cord-015021-pol2qm74	1053	2	eliminate	eliminate	VB
cord-015021-pol2qm74	1053	3	the	the	DT
cord-015021-pol2qm74	1053	4	transmembrane	transmembrane	NN
cord-015021-pol2qm74	1053	5	control	control	NN
cord-015021-pol2qm74	1053	6	of	of	IN
cord-015021-pol2qm74	1053	7	calcium	calcium	NN
cord-015021-pol2qm74	1053	8	and	and	CC
cord-015021-pol2qm74	1053	9	test	test	VB
cord-015021-pol2qm74	1053	10	the	the	DT
cord-015021-pol2qm74	1053	11	intrinsic	intrinsic	JJ
cord-015021-pol2qm74	1053	12	contractile	contractile	JJ
cord-015021-pol2qm74	1053	13	response	response	NN
cord-015021-pol2qm74	1053	14	,	,	,
cord-015021-pol2qm74	1053	15	hypothermia	hypothermia	NN
cord-015021-pol2qm74	1053	16	(	(	-LRB-
cord-015021-pol2qm74	1053	17	22	22	CD
cord-015021-pol2qm74	1053	18	°	°	NN
cord-015021-pol2qm74	1053	19	C	c	NN
cord-015021-pol2qm74	1053	20	)	)	-RRB-
cord-015021-pol2qm74	1053	21	was	be	VBD
cord-015021-pol2qm74	1053	22	used	use	VBN
cord-015021-pol2qm74	1053	23	The	the	DT
cord-015021-pol2qm74	1053	24	results	result	NNS
cord-015021-pol2qm74	1053	25	showed	show	VBD
cord-015021-pol2qm74	1053	26	alterations	alteration	NNS
cord-015021-pol2qm74	1053	27	in	in	IN
cord-015021-pol2qm74	1053	28	the	the	DT
cord-015021-pol2qm74	1053	29	inotropic	inotropic	NNP
cord-015021-pol2qm74	1053	30	function	function	VBP
cord-015021-pol2qm74	1053	31	with	with	IN
cord-015021-pol2qm74	1053	32	no	no	DT
cord-015021-pol2qm74	1053	33	significant	significant	JJ
cord-015021-pol2qm74	1053	34	difference	difference	NN
cord-015021-pol2qm74	1053	35	in	in	IN
cord-015021-pol2qm74	1053	36	chronotropic	chronotropic	JJ
cord-015021-pol2qm74	1053	37	response	response	NN
cord-015021-pol2qm74	1053	38	.	.	.
cord-015021-pol2qm74	1054	1	The	the	DT
cord-015021-pol2qm74	1054	2	inotropic	inotropic	NNP
cord-015021-pol2qm74	1054	3	reponse	reponse	NN
cord-015021-pol2qm74	1054	4	for	for	IN
cord-015021-pol2qm74	1054	5	the	the	DT
cord-015021-pol2qm74	1054	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1054	7	exposed	expose	VBN
cord-015021-pol2qm74	1054	8	atria	atria	NN
cord-015021-pol2qm74	1054	9	and	and	CC
cord-015021-pol2qm74	1054	10	controls	control	NNS
cord-015021-pol2qm74	1054	11	is	be	VBZ
cord-015021-pol2qm74	1054	12	shown	show	VBN
cord-015021-pol2qm74	1054	13	below	below	IN
cord-015021-pol2qm74	1054	14	These	these	DT
cord-015021-pol2qm74	1054	15	results	result	NNS
cord-015021-pol2qm74	1054	16	show	show	VBP
cord-015021-pol2qm74	1054	17	that	that	IN
cord-015021-pol2qm74	1054	18	there	there	EX
cord-015021-pol2qm74	1054	19	is	be	VBZ
cord-015021-pol2qm74	1054	20	a	a	DT
cord-015021-pol2qm74	1054	21	transmembrane	transmembrane	NN
cord-015021-pol2qm74	1054	22	signal	signal	NN
cord-015021-pol2qm74	1054	23	defect	defect	NN
cord-015021-pol2qm74	1054	24	both	both	CC
cord-015021-pol2qm74	1054	25	for	for	IN
cord-015021-pol2qm74	1054	26	the	the	DT
cord-015021-pol2qm74	1054	27	I~-AR	i~-ar	JJ
cord-015021-pol2qm74	1054	28	signal	signal	NN
cord-015021-pol2qm74	1054	29	and	and	CC
cord-015021-pol2qm74	1054	30	for	for	IN
cord-015021-pol2qm74	1054	31	Ca	Ca	NNP
cord-015021-pol2qm74	1055	1	+	+	UH
cord-015021-pol2qm74	1055	2	.	.	.
cord-015021-pol2qm74	1056	1	These	these	DT
cord-015021-pol2qm74	1056	2	data	datum	NNS
cord-015021-pol2qm74	1056	3	indicate	indicate	VBP
cord-015021-pol2qm74	1056	4	that	that	IN
cord-015021-pol2qm74	1056	5	the	the	DT
cord-015021-pol2qm74	1056	6	level	level	NN
cord-015021-pol2qm74	1056	7	of	of	IN
cord-015021-pol2qm74	1056	8	the	the	DT
cord-015021-pol2qm74	1056	9	defect	defect	NN
cord-015021-pol2qm74	1056	10	appears	appear	VBZ
cord-015021-pol2qm74	1056	11	to	to	TO
cord-015021-pol2qm74	1056	12	be	be	VB
cord-015021-pol2qm74	1056	13	at	at	IN
cord-015021-pol2qm74	1056	14	the	the	DT
cord-015021-pol2qm74	1056	15	G	g	NN
cord-015021-pol2qm74	1056	16	proteins	protein	NNS
cord-015021-pol2qm74	1056	17	.	.	.
cord-015021-pol2qm74	1057	1	Ischemia	ischemia	NN
cord-015021-pol2qm74	1057	2	-	-	HYPH
cord-015021-pol2qm74	1057	3	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1057	4	of	of	IN
cord-015021-pol2qm74	1057	5	the	the	DT
cord-015021-pol2qm74	1057	6	rat	rat	NN
cord-015021-pol2qm74	1057	7	intestine	intestine	NN
cord-015021-pol2qm74	1057	8	produces	produce	VBZ
cord-015021-pol2qm74	1057	9	an	an	DT
cord-015021-pol2qm74	1057	10	injmry	injmry	NN
cord-015021-pol2qm74	1057	11	both	both	DT
cord-015021-pol2qm74	1057	12	to	to	IN
cord-015021-pol2qm74	1057	13	the	the	DT
cord-015021-pol2qm74	1057	14	intestine	intestine	NN
cord-015021-pol2qm74	1057	15	and	and	CC
cord-015021-pol2qm74	1057	16	to	to	IN
cord-015021-pol2qm74	1057	17	distal	distal	JJ
cord-015021-pol2qm74	1057	18	organs	organ	NNS
cord-015021-pol2qm74	1057	19	,	,	,
cord-015021-pol2qm74	1057	20	notably	notably	RB
cord-015021-pol2qm74	1057	21	the	the	DT
cord-015021-pol2qm74	1057	22	lungs	lung	NNS
cord-015021-pol2qm74	1057	23	and	and	CC
cord-015021-pol2qm74	1057	24	liver	liver	NN
cord-015021-pol2qm74	1057	25	.	.	.
cord-015021-pol2qm74	1058	1	Prior	prior	JJ
cord-015021-pol2qm74	1058	2	studies	study	NNS
cord-015021-pol2qm74	1058	3	have	have	VBP
cord-015021-pol2qm74	1058	4	shown	show	VBN
cord-015021-pol2qm74	1058	5	that	that	IN
cord-015021-pol2qm74	1058	6	1	1	CD
cord-015021-pol2qm74	1058	7	h	h	NN
cord-015021-pol2qm74	1058	8	of	of	IN
cord-015021-pol2qm74	1058	9	intestinal	intestinal	JJ
cord-015021-pol2qm74	1058	10	ischemia	ischemia	NN
cord-015021-pol2qm74	1058	11	leads	lead	VBZ
cord-015021-pol2qm74	1058	12	to	to	IN
cord-015021-pol2qm74	1058	13	a	a	DT
cord-015021-pol2qm74	1058	14	nemtrophil	nemtrophil	JJ
cord-015021-pol2qm74	1058	15	independent	independent	JJ
cord-015021-pol2qm74	1058	16	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1058	17	injury	injury	NN
cord-015021-pol2qm74	1058	18	of	of	IN
cord-015021-pol2qm74	1058	19	the	the	DT
cord-015021-pol2qm74	1058	20	gut	gut	NN
cord-015021-pol2qm74	1058	21	.	.	.
cord-015021-pol2qm74	1059	1	Thus	thus	RB
cord-015021-pol2qm74	1059	2	,	,	,
cord-015021-pol2qm74	1059	3	rats	rat	NNS
cord-015021-pol2qm74	1059	4	rendered	render	VBN
cord-015021-pol2qm74	1059	5	neutropenic	neutropenic	JJ
cord-015021-pol2qm74	1059	6	by	by	IN
cord-015021-pol2qm74	1059	7	Pl	Pl	NNP
cord-015021-pol2qm74	1059	8	~	~	NNP
cord-015021-pol2qm74	1059	9	l	l	NNP
cord-015021-pol2qm74	1059	10	antiserum	antiserum	NNP
cord-015021-pol2qm74	1059	11	have	have	VBP
cord-015021-pol2qm74	1059	12	been	be	VBN
cord-015021-pol2qm74	1059	13	shown	show	VBN
cord-015021-pol2qm74	1059	14	to	to	TO
cord-015021-pol2qm74	1059	15	express	express	VB
cord-015021-pol2qm74	1059	16	a	a	DT
cord-015021-pol2qm74	1059	17	severe	severe	JJ
cord-015021-pol2qm74	1059	18	local	local	JJ
cord-015021-pol2qm74	1059	19	gut	gut	NN
cord-015021-pol2qm74	1059	20	injury	injury	NN
cord-015021-pol2qm74	1059	21	when	when	WRB
cord-015021-pol2qm74	1059	22	subjected	subject	VBN
cord-015021-pol2qm74	1059	23	to	to	IN
cord-015021-pol2qm74	1059	24	ischemia	ischemia	NN
cord-015021-pol2qm74	1059	25	and	and	CC
cord-015021-pol2qm74	1059	26	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1059	27	.	.	.
cord-015021-pol2qm74	1060	1	This	this	DT
cord-015021-pol2qm74	1060	2	gut	gut	NN
cord-015021-pol2qm74	1060	3	injury	injury	NN
cord-015021-pol2qm74	1060	4	is	be	VBZ
cord-015021-pol2qm74	1060	5	postulated	postulate	VBN
cord-015021-pol2qm74	1060	6	to	to	IN
cord-015021-pol2qm74	1060	7	he	-PRON-	PRP
cord-015021-pol2qm74	1060	8	mediated	mediate	VBD
cord-015021-pol2qm74	1060	9	at	at	IN
cord-015021-pol2qm74	1060	10	least	least	JJS
cord-015021-pol2qm74	1060	11	in	in	IN
cord-015021-pol2qm74	1060	12	part	part	NN
cord-015021-pol2qm74	1060	13	by	by	IN
cord-015021-pol2qm74	1060	14	the	the	DT
cord-015021-pol2qm74	1060	15	complement	complement	NN
cord-015021-pol2qm74	1060	16	system	system	NN
cord-015021-pol2qm74	1060	17	.	.	.
cord-015021-pol2qm74	1061	1	The	the	DT
cord-015021-pol2qm74	1061	2	soluble	soluble	JJ
cord-015021-pol2qm74	1061	3	(	(	-LRB-
cord-015021-pol2qm74	1061	4	s	s	NNS
cord-015021-pol2qm74	1061	5	)	)	-RRB-
cord-015021-pol2qm74	1061	6	CRI	cri	NN
cord-015021-pol2qm74	1061	7	receptor	receptor	NN
cord-015021-pol2qm74	1061	8	which	which	WDT
cord-015021-pol2qm74	1061	9	binds	bind	VBZ
cord-015021-pol2qm74	1061	10	to	to	IN
cord-015021-pol2qm74	1061	11	C3b	C3b	NNP
cord-015021-pol2qm74	1061	12	and	and	CC
cord-015021-pol2qm74	1061	13	Cdb	Cdb	NNP
cord-015021-pol2qm74	1061	14	was	be	VBD
cord-015021-pol2qm74	1061	15	given	give	VBN
cord-015021-pol2qm74	1061	16	to	to	IN
cord-015021-pol2qm74	1061	17	rats	rat	NNS
cord-015021-pol2qm74	1061	18	at	at	IN
cord-015021-pol2qm74	1061	19	a	a	DT
cord-015021-pol2qm74	1061	20	dose	dose	NN
cord-015021-pol2qm74	1061	21	of	of	IN
cord-015021-pol2qm74	1061	22	12	12	CD
cord-015021-pol2qm74	1061	23	mg	mg	NNP
cord-015021-pol2qm74	1061	24	/	/	SYM
cord-015021-pol2qm74	1061	25	kg	kg	NNS
cord-015021-pol2qm74	1061	26	by	by	IN
cord-015021-pol2qm74	1061	27	intravenous	intravenous	JJ
cord-015021-pol2qm74	1061	28	bolus	bolus	NN
cord-015021-pol2qm74	1061	29	,	,	,
cord-015021-pol2qm74	1061	30	15	15	CD
cord-015021-pol2qm74	1061	31	min	min	NN
cord-015021-pol2qm74	1061	32	before	before	IN
cord-015021-pol2qm74	1061	33	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1061	34	of	of	IN
cord-015021-pol2qm74	1061	35	the	the	DT
cord-015021-pol2qm74	1061	36	ischemic	ischemic	JJ
cord-015021-pol2qm74	1061	37	gut	gut	NN
cord-015021-pol2qm74	1061	38	.	.	.
cord-015021-pol2qm74	1062	1	A	a	DT
cord-015021-pol2qm74	1062	2	control	control	NN
cord-015021-pol2qm74	1062	3	group	group	NN
cord-015021-pol2qm74	1062	4	was	be	VBD
cord-015021-pol2qm74	1062	5	given	give	VBN
cord-015021-pol2qm74	1062	6	PBS	PBS	NNP
cord-015021-pol2qm74	1062	7	buffer	buffer	NN
cord-015021-pol2qm74	1062	8	.	.	.
cord-015021-pol2qm74	1063	1	At	at	IN
cord-015021-pol2qm74	1063	2	4	4	CD
cord-015021-pol2qm74	1063	3	h	h	NN
cord-015021-pol2qm74	1063	4	of	of	IN
cord-015021-pol2qm74	1063	5	rmperfmsion	rmperfmsion	NN
cord-015021-pol2qm74	1063	6	the	the	DT
cord-015021-pol2qm74	1063	7	animals	animal	NNS
cord-015021-pol2qm74	1063	8	were	be	VBD
cord-015021-pol2qm74	1063	9	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	1063	10	.	.	.
cord-015021-pol2qm74	1064	1	PBS	PBS	NNP
cord-015021-pol2qm74	1064	2	treatment	treatment	NN
cord-015021-pol2qm74	1064	3	led	lead	VBD
cord-015021-pol2qm74	1064	4	to	to	IN
cord-015021-pol2qm74	1064	5	a	a	DT
cord-015021-pol2qm74	1064	6	significant	significant	JJ
cord-015021-pol2qm74	1064	7	activation	activation	NN
cord-015021-pol2qm74	1064	8	of	of	IN
cord-015021-pol2qm74	1064	9	both	both	DT
cord-015021-pol2qm74	1064	10	classical	classical	JJ
cord-015021-pol2qm74	1064	11	and	and	CC
cord-015021-pol2qm74	1064	12	alternate	alternate	JJ
cord-015021-pol2qm74	1064	13	complement	complement	NN
cord-015021-pol2qm74	1064	14	pathways	pathway	NNS
cord-015021-pol2qm74	1064	15	while	while	IN
cord-015021-pol2qm74	1064	16	sCRI	sCRI	VBG
cord-015021-pol2qm74	1064	17	inhibited	inhibit	VBD
cord-015021-pol2qm74	1064	18	both	both	DT
cord-015021-pol2qm74	1064	19	pathways	pathway	NNS
cord-015021-pol2qm74	1064	20	(	(	-LRB-
cord-015021-pol2qm74	1064	21	fall	fall	VB
cord-015021-pol2qm74	1064	22	to	to	IN
cord-015021-pol2qm74	1064	23	zero	zero	CD
cord-015021-pol2qm74	1064	24	of	of	IN
cord-015021-pol2qm74	1064	25	CHbo	CHbo	NNP
cord-015021-pol2qm74	1064	26	)	)	-RRB-
cord-015021-pol2qm74	1064	27	.	.	.
cord-015021-pol2qm74	1065	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	1065	2	mucosal	mucosal	JJ
cord-015021-pol2qm74	1065	3	injury	injury	NN
cord-015021-pol2qm74	1065	4	score	score	NN
cord-015021-pol2qm74	1065	5	,	,	,
cord-015021-pol2qm74	1065	6	assessed	assess	VBN
cord-015021-pol2qm74	1065	7	by	by	IN
cord-015021-pol2qm74	1065	8	histological	histological	JJ
cord-015021-pol2qm74	1065	9	grading	grading	NN
cord-015021-pol2qm74	1065	10	was	be	VBD
cord-015021-pol2qm74	1065	11	reduced	reduce	VBN
cord-015021-pol2qm74	1065	12	by	by	IN
cord-015021-pol2qm74	1065	13	sCRI	sCRI	VBG
cord-015021-pol2qm74	1065	14	(	(	-LRB-
cord-015021-pol2qm74	1065	15	2.49±0.22	2.49±0.22	CD
cord-015021-pol2qm74	1065	16	to	to	IN
cord-015021-pol2qm74	1065	17	1.73_+0.17,p<0.05	1.73_+0.17,p<0.05	CD
cord-015021-pol2qm74	1065	18	)	)	-RRB-
cord-015021-pol2qm74	1065	19	.	.	.
cord-015021-pol2qm74	1066	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	1066	2	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1066	3	sequestration	sequestration	NN
cord-015021-pol2qm74	1066	4	estimated	estimate	VBN
cord-015021-pol2qm74	1066	5	by	by	IN
cord-015021-pol2qm74	1066	6	assay	assay	NN
cord-015021-pol2qm74	1066	7	of	of	IN
cord-015021-pol2qm74	1066	8	myeleperoxidase	myeleperoxidase	NNP
cord-015021-pol2qm74	1066	9	was	be	VBD
cord-015021-pol2qm74	1066	10	also	also	RB
cord-015021-pol2qm74	1066	11	reduced	reduce	VBN
cord-015021-pol2qm74	1066	12	(	(	-LRB-
cord-015021-pol2qm74	1066	13	0.05	0.05	CD
cord-015021-pol2qm74	1066	14	±	±	CD
cord-015021-pol2qm74	1066	15	0.01	0.01	CD
cord-015021-pol2qm74	1066	16	to	to	IN
cord-015021-pol2qm74	1066	17	0.02	0.02	CD
cord-015021-pol2qm74	1066	18	±	±	CD
cord-015021-pol2qm74	1066	19	0.01	0.01	CD
cord-015021-pol2qm74	1066	20	U	U	NNP
cord-015021-pol2qm74	1066	21	/	/	SYM
cord-015021-pol2qm74	1066	22	g	g	NN
cord-015021-pol2qm74	1066	23	)	)	-RRB-
cord-015021-pol2qm74	1066	24	.	.	.
cord-015021-pol2qm74	1067	1	C3	C3	NNP
cord-015021-pol2qm74	1067	2	was	be	VBD
cord-015021-pol2qm74	1067	3	detected	detect	VBN
cord-015021-pol2qm74	1067	4	in	in	IN
cord-015021-pol2qm74	1067	5	the	the	DT
cord-015021-pol2qm74	1067	6	gut	gut	NN
cord-015021-pol2qm74	1068	1	hy	hy	NNP
cord-015021-pol2qm74	1069	1	i	i	PRP
cord-015021-pol2qm74	1069	2	~	~	CD
cord-015021-pol2qm74	1069	3	unohistochemistry	unohistochemistry	NNP
cord-015021-pol2qm74	1069	4	.	.	.
cord-015021-pol2qm74	1070	1	Remote	remote	JJ
cord-015021-pol2qm74	1070	2	organ	organ	NN
cord-015021-pol2qm74	1070	3	injury	injury	NN
cord-015021-pol2qm74	1070	4	was	be	VBD
cord-015021-pol2qm74	1070	5	modified	modify	VBN
cord-015021-pol2qm74	1070	6	that	that	WDT
cord-015021-pol2qm74	1070	7	is	be	VBZ
cord-015021-pol2qm74	1070	8	lung	lung	NN
cord-015021-pol2qm74	1070	9	permeability	permeability	NN
cord-015021-pol2qm74	1070	10	(	(	-LRB-
cord-015021-pol2qm74	1070	11	ration	ration	NN
cord-015021-pol2qm74	1070	12	of	of	IN
cord-015021-pol2qm74	1070	13	concentration	concentration	NN
cord-015021-pol2qm74	1070	14	of	of	IN
cord-015021-pol2qm74	1070	15	radiolabelled	radiolabelled	JJ
cord-015021-pol2qm74	1070	16	albumin	albumin	NN
cord-015021-pol2qm74	1070	17	in	in	IN
cord-015021-pol2qm74	1070	18	broncho	broncho	JJ
cord-015021-pol2qm74	1070	19	-	-	HYPH
cord-015021-pol2qm74	1070	20	alveolar	alveolar	NN
cord-015021-pol2qm74	1070	21	lavage	lavage	NN
cord-015021-pol2qm74	1070	22	fluid	fluid	NN
cord-015021-pol2qm74	1070	23	to	to	IN
cord-015021-pol2qm74	1070	24	that	that	DT
cord-015021-pol2qm74	1070	25	in	in	IN
cord-015021-pol2qm74	1070	26	blood	blood	NN
cord-015021-pol2qm74	1070	27	)	)	-RRB-
cord-015021-pol2qm74	1070	28	was	be	VBD
cord-015021-pol2qm74	1070	29	reduced	reduce	VBN
cord-015021-pol2qm74	1071	1	(	(	-LRB-
cord-015021-pol2qm74	1071	2	11.3±1.4	11.3±1.4	CD
cord-015021-pol2qm74	1071	3	x	x	SYM
cord-015021-pol2qm74	1071	4	i0	i0	NN
cord-015021-pol2qm74	1071	5	3	3	CD
cord-015021-pol2qm74	1071	6	to	to	IN
cord-015021-pol2qm74	1071	7	3.9±0.8	3.9±0.8	CD
cord-015021-pol2qm74	1071	8	x	x	SYM
cord-015021-pol2qm74	1071	9	103	103	CD
cord-015021-pol2qm74	1071	10	,	,	,
cord-015021-pol2qm74	1072	1	p	p	NN
cord-015021-pol2qm74	1072	2	<	<	XX
cord-015021-pol2qm74	1072	3	O.05	o.05	NN
cord-015021-pol2qm74	1072	4	)	)	-RRB-
cord-015021-pol2qm74	1072	5	.	.	.
cord-015021-pol2qm74	1073	1	However	however	RB
cord-015021-pol2qm74	1073	2	,	,	,
cord-015021-pol2qm74	1073	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1073	4	sequestration	sequestration	NN
cord-015021-pol2qm74	1073	5	by	by	IN
cord-015021-pol2qm74	1073	6	the	the	DT
cord-015021-pol2qm74	1073	7	lungs	lung	NNS
cord-015021-pol2qm74	1073	8	was	be	VBD
cord-015021-pol2qm74	1073	9	unaffected	unaffected	JJ
cord-015021-pol2qm74	1073	10	.	.	.
cord-015021-pol2qm74	1074	1	This	this	DT
cord-015021-pol2qm74	1074	2	remote	remote	JJ
cord-015021-pol2qm74	1074	3	protection	protection	NN
cord-015021-pol2qm74	1074	4	is	be	VBZ
cord-015021-pol2qm74	1074	5	thougth	thougth	VBN
cord-015021-pol2qm74	1074	6	to	to	TO
cord-015021-pol2qm74	1074	7	be	be	VB
cord-015021-pol2qm74	1074	8	related	relate	VBN
cord-015021-pol2qm74	1074	9	to	to	IN
cord-015021-pol2qm74	1074	10	prevention	prevention	NN
cord-015021-pol2qm74	1074	11	of	of	IN
cord-015021-pol2qm74	1074	12	iC3b	iC3b	NNP
cord-015021-pol2qm74	1074	13	deposition	deposition	NN
cord-015021-pol2qm74	1074	14	on	on	IN
cord-015021-pol2qm74	1074	15	Imng	Imng	NNP
cord-015021-pol2qm74	1074	16	andotheli~	andotheli~	NNP
cord-015021-pol2qm74	1074	17	which	which	WDT
cord-015021-pol2qm74	1074	18	activates	activate	VBZ
cord-015021-pol2qm74	1074	19	adherent	adherent	JJ
cord-015021-pol2qm74	1074	20	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1074	21	.	.	.
cord-015021-pol2qm74	1075	1	These	these	DT
cord-015021-pol2qm74	1075	2	findings	finding	NNS
cord-015021-pol2qm74	1075	3	support	support	VBP
cord-015021-pol2qm74	1075	4	the	the	DT
cord-015021-pol2qm74	1075	5	hypothesis	hypothesis	NN
cord-015021-pol2qm74	1075	6	of	of	IN
cord-015021-pol2qm74	1075	7	complement	complement	NN
cord-015021-pol2qm74	1075	8	mediated	mediate	VBN
cord-015021-pol2qm74	1075	9	local	local	JJ
cord-015021-pol2qm74	1075	10	and	and	CC
cord-015021-pol2qm74	1075	11	remote	remote	JJ
cord-015021-pol2qm74	1075	12	injury	injury	NN
cord-015021-pol2qm74	1075	13	.	.	.
cord-015021-pol2qm74	1076	1	We	-PRON-	PRP
cord-015021-pol2qm74	1076	2	postulate	postulate	VBP
cord-015021-pol2qm74	1076	3	that	that	IN
cord-015021-pol2qm74	1076	4	complement	complement	NN
cord-015021-pol2qm74	1076	5	fragments	fragment	NNS
cord-015021-pol2qm74	1076	6	may	may	MD
cord-015021-pol2qm74	1076	7	be	be	VB
cord-015021-pol2qm74	1076	8	deposited	deposit	VBN
cord-015021-pol2qm74	1076	9	either	either	CC
cord-015021-pol2qm74	1076	10	as	as	IN
cord-015021-pol2qm74	1076	11	a	a	DT
cord-015021-pol2qm74	1076	12	result	result	NN
cord-015021-pol2qm74	1076	13	of	of	IN
cord-015021-pol2qm74	1076	14	the	the	DT
cord-015021-pol2qm74	1076	15	ischemia	ischemia	NN
cord-015021-pol2qm74	1076	16	induced	induce	VBN
cord-015021-pol2qm74	1076	17	loss	loss	NN
cord-015021-pol2qm74	1076	18	of	of	IN
cord-015021-pol2qm74	1076	19	membrane	membrane	NN
cord-015021-pol2qm74	1076	20	bound	bind	VBN
cord-015021-pol2qm74	1076	21	complement	complement	VBP
cord-015021-pol2qm74	1076	22	regulatory	regulatory	JJ
cord-015021-pol2qm74	1076	23	proteins	protein	NNS
cord-015021-pol2qm74	1076	24	,	,	,
cord-015021-pol2qm74	1076	25	such	such	JJ
cord-015021-pol2qm74	1076	26	as	as	IN
cord-015021-pol2qm74	1076	27	decay	decay	NN
cord-015021-pol2qm74	1076	28	accelerating	accelerate	VBG
cord-015021-pol2qm74	1076	29	factor	factor	NN
cord-015021-pol2qm74	1076	30	or	or	CC
cord-015021-pol2qm74	1076	31	membrane	membrane	NN
cord-015021-pol2qm74	1076	32	cofactor	cofactor	NN
cord-015021-pol2qm74	1076	33	protein	protein	NN
cord-015021-pol2qm74	1076	34	,	,	,
cord-015021-pol2qm74	1076	35	which	which	WDT
cord-015021-pol2qm74	1076	36	allow	allow	VBP
cord-015021-pol2qm74	1076	37	complement	complement	NN
cord-015021-pol2qm74	1076	38	fragments	fragment	NNS
cord-015021-pol2qm74	1076	39	to	to	TO
cord-015021-pol2qm74	1076	40	accumulate	accumulate	VB
cord-015021-pol2qm74	1076	41	on	on	IN
cord-015021-pol2qm74	1076	42	the	the	DT
cord-015021-pol2qm74	1076	43	endothelial	endothelial	JJ
cord-015021-pol2qm74	1076	44	cell	cell	NN
cord-015021-pol2qm74	1076	45	surface	surface	NN
cord-015021-pol2qm74	1076	46	.	.	.
cord-015021-pol2qm74	1077	1	Alternatively	alternatively	RB
cord-015021-pol2qm74	1077	2	,	,	,
cord-015021-pol2qm74	1077	3	increased	increase	VBN
cord-015021-pol2qm74	1077	4	expression	expression	NN
cord-015021-pol2qm74	1077	5	of	of	IN
cord-015021-pol2qm74	1077	6	P	p	NN
cord-015021-pol2qm74	1077	7	-	-	HYPH
cord-015021-pol2qm74	1077	8	selectin	selectin	NNP
cord-015021-pol2qm74	1077	9	on	on	IN
cord-015021-pol2qm74	1077	10	the	the	DT
cord-015021-pol2qm74	1077	11	endothelial	endothelial	JJ
cord-015021-pol2qm74	1077	12	cell	cell	NN
cord-015021-pol2qm74	1077	13	surface	surface	NN
cord-015021-pol2qm74	1077	14	may	may	MD
cord-015021-pol2qm74	1077	15	,	,	,
cord-015021-pol2qm74	1077	16	by	by	IN
cord-015021-pol2qm74	1077	17	means	mean	NNS
cord-015021-pol2qm74	1077	18	of	of	IN
cord-015021-pol2qm74	1077	19	its	-PRON-	PRP$
cord-015021-pol2qm74	1077	20	complement	complement	NN
cord-015021-pol2qm74	1077	21	binding	bind	VBG
cord-015021-pol2qm74	1077	22	domains	domain	NNS
cord-015021-pol2qm74	1077	23	,	,	,
cord-015021-pol2qm74	1077	24	act	act	VB
cord-015021-pol2qm74	1077	25	as	as	IN
cord-015021-pol2qm74	1077	26	a	a	DT
cord-015021-pol2qm74	1077	27	lattice	lattice	NN
cord-015021-pol2qm74	1077	28	for	for	IN
cord-015021-pol2qm74	1077	29	complement	complement	JJ
cord-015021-pol2qm74	1077	30	deposition	deposition	NN
cord-015021-pol2qm74	1077	31	.	.	.
cord-015021-pol2qm74	1078	1	Indeed	indeed	RB
cord-015021-pol2qm74	1078	2	,	,	,
cord-015021-pol2qm74	1078	3	P	p	NN
cord-015021-pol2qm74	1078	4	-	-	HYPH
cord-015021-pol2qm74	1078	5	selectin	selectin	NNP
cord-015021-pol2qm74	1078	6	has	have	VBZ
cord-015021-pol2qm74	1078	7	been	be	VBN
cord-015021-pol2qm74	1078	8	detected	detect	VBN
cord-015021-pol2qm74	1078	9	on	on	IN
cord-015021-pol2qm74	1078	10	the	the	DT
cord-015021-pol2qm74	1078	11	surface	surface	NN
cord-015021-pol2qm74	1078	12	of	of	IN
cord-015021-pol2qm74	1078	13	endothelial	endothelial	JJ
cord-015021-pol2qm74	1078	14	cells	cell	NNS
cord-015021-pol2qm74	1078	15	ans	ans	POS
cord-015021-pol2qm74	1078	16	platelet	platelet	NN
cord-015021-pol2qm74	1078	17	-	-	HYPH
cord-015021-pol2qm74	1078	18	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1078	19	aggregates	aggregate	NNS
cord-015021-pol2qm74	1078	20	recovered	recover	VBD
cord-015021-pol2qm74	1078	21	from	from	IN
cord-015021-pol2qm74	1078	22	the	the	DT
cord-015021-pol2qm74	1078	23	intestine	intestine	NN
cord-015021-pol2qm74	1078	24	of	of	IN
cord-015021-pol2qm74	1078	25	these	these	DT
cord-015021-pol2qm74	1078	26	animals	animal	NNS
cord-015021-pol2qm74	1078	27	.	.	.
cord-015021-pol2qm74	1079	1	Ischemia	ischemia	NN
cord-015021-pol2qm74	1079	2	(	(	-LRB-
cord-015021-pol2qm74	1079	3	4hr	4hr	NNP
cord-015021-pol2qm74	1079	4	)	)	-RRB-
cord-015021-pol2qm74	1079	5	followed	follow	VBN
cord-015021-pol2qm74	1079	6	by	by	IN
cord-015021-pol2qm74	1079	7	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1079	8	(	(	-LRB-
cord-015021-pol2qm74	1079	9	dhr	dhr	NNP
cord-015021-pol2qm74	1079	10	)	)	-RRB-
cord-015021-pol2qm74	1079	11	of	of	IN
cord-015021-pol2qm74	1079	12	rat	rat	NN
cord-015021-pol2qm74	1079	13	hind	hind	NN
cord-015021-pol2qm74	1079	14	limbs	limb	NNS
cord-015021-pol2qm74	1079	15	resuits	resuit	NNS
cord-015021-pol2qm74	1079	16	in	in	IN
cord-015021-pol2qm74	1079	17	local	local	JJ
cord-015021-pol2qm74	1079	18	(	(	-LRB-
cord-015021-pol2qm74	1079	19	muscle	muscle	NN
cord-015021-pol2qm74	1079	20	)	)	-RRB-
cord-015021-pol2qm74	1079	21	injury	injury	NN
cord-015021-pol2qm74	1079	22	as	as	RB
cord-015021-pol2qm74	1079	23	well	well	RB
cord-015021-pol2qm74	1079	24	as	as	IN
cord-015021-pol2qm74	1079	25	in	in	IN
cord-015021-pol2qm74	1079	26	remote	remote	JJ
cord-015021-pol2qm74	1079	27	(	(	-LRB-
cord-015021-pol2qm74	1079	28	lung	lung	NN
cord-015021-pol2qm74	1079	29	)	)	-RRB-
cord-015021-pol2qm74	1079	30	injury	injury	NN
cord-015021-pol2qm74	1079	31	,	,	,
cord-015021-pol2qm74	1079	32	which	which	WDT
cord-015021-pol2qm74	1079	33	is	be	VBZ
cord-015021-pol2qm74	1079	34	characterized	characterize	VBN
cord-015021-pol2qm74	1079	35	by	by	IN
cord-015021-pol2qm74	1079	36	increased	increase	VBN
cord-015021-pol2qm74	1079	37	vascular	vascular	JJ
cord-015021-pol2qm74	1079	38	permeability	permeability	NN
cord-015021-pol2qm74	1079	39	(	(	-LRB-
cord-015021-pol2qm74	1079	40	leakage	leakage	NN
cord-015021-pol2qm74	1079	41	of	of	IN
cord-015021-pol2qm74	1079	42	J2Sl	J2Sl	NNP
cord-015021-pol2qm74	1079	43	labeled	label	VBN
cord-015021-pol2qm74	1079	44	albumin	albumin	NN
cord-015021-pol2qm74	1079	45	)	)	-RRB-
cord-015021-pol2qm74	1079	46	and	and	CC
cord-015021-pol2qm74	1079	47	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1079	48	accumulation	accumulation	NN
cord-015021-pol2qm74	1079	49	(	(	-LRB-
cord-015021-pol2qm74	1079	50	tissue	tissue	NN
cord-015021-pol2qm74	1079	51	content	content	NN
cord-015021-pol2qm74	1079	52	of	of	IN
cord-015021-pol2qm74	1079	53	myeloperoxidase	myeloperoxidase	NN
cord-015021-pol2qm74	1079	54	,	,	,
cord-015021-pol2qm74	1079	55	MPO	MPO	NNP
cord-015021-pol2qm74	1079	56	)	)	-RRB-
cord-015021-pol2qm74	1079	57	.	.	.
cord-015021-pol2qm74	1080	1	Within	within	IN
cord-015021-pol2qm74	1080	2	60	60	CD
cord-015021-pol2qm74	1080	3	minutes	minute	NNS
cord-015021-pol2qm74	1080	4	of	of	IN
cord-015021-pol2qm74	1080	5	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1080	6	following	follow	VBG
cord-015021-pol2qm74	1080	7	ischemia	ischemia	NN
cord-015021-pol2qm74	1080	8	,	,	,
cord-015021-pol2qm74	1080	9	tumor	tumor	NN
cord-015021-pol2qm74	1080	10	necrosis	necrosis	NN
cord-015021-pol2qm74	1080	11	factor	factor	NN
cord-015021-pol2qm74	1080	12	-	-	HYPH
cord-015021-pol2qm74	1080	13	o~	o~	NN
cord-015021-pol2qm74	1080	14	(	(	-LRB-
cord-015021-pol2qm74	1080	15	TNFc	TNFc	NNP
cord-015021-pol2qm74	1080	16	0	0	CD
cord-015021-pol2qm74	1080	17	,	,	,
cord-015021-pol2qm74	1080	18	interleukin	interleukin	NN
cord-015021-pol2qm74	1080	19	-	-	:
cord-015021-pol2qm74	1080	20	I	i	NN
cord-015021-pol2qm74	1080	21	(	(	-LRB-
cord-015021-pol2qm74	1080	22	1L	1l	CD
cord-015021-pol2qm74	1080	23	-	-	HYPH
cord-015021-pol2qm74	1080	24	I	i	NN
cord-015021-pol2qm74	1080	25	)	)	-RRB-
cord-015021-pol2qm74	1080	26	and	and	CC
cord-015021-pol2qm74	1080	27	IL-6	IL-6	NNP
cord-015021-pol2qm74	1080	28	plasma	plasma	NN
cord-015021-pol2qm74	1080	29	levels	level	NNS
cord-015021-pol2qm74	1080	30	increased	increase	VBD
cord-015021-pol2qm74	1080	31	significantly	significantly	RB
cord-015021-pol2qm74	1080	32	,	,	,
cord-015021-pol2qm74	1080	33	reaching	reach	VBG
cord-015021-pol2qm74	1080	34	maximum	maximum	JJ
cord-015021-pol2qm74	1080	35	levels	level	NNS
cord-015021-pol2qm74	1080	36	after	after	IN
cord-015021-pol2qm74	1080	37	2	2	CD
cord-015021-pol2qm74	1080	38	hours	hour	NNS
cord-015021-pol2qm74	1080	39	ofreperfusion	ofreperfusion	NN
cord-015021-pol2qm74	1080	40	.	.	.
cord-015021-pol2qm74	1081	1	Polyclonal	Polyclonal	NNP
cord-015021-pol2qm74	1081	2	antibodies	antibody	NNS
cord-015021-pol2qm74	1081	3	to	to	IN
cord-015021-pol2qm74	1081	4	TNFet	TNFet	NNP
cord-015021-pol2qm74	1081	5	and	and	CC
cord-015021-pol2qm74	1081	6	1L	1l	CD
cord-015021-pol2qm74	1082	1	-I	-i	DT
cord-015021-pol2qm74	1082	2	provided	provide	VBD
cord-015021-pol2qm74	1082	3	significant	significant	JJ
cord-015021-pol2qm74	1082	4	protection	protection	NN
cord-015021-pol2qm74	1082	5	against	against	IN
cord-015021-pol2qm74	1082	6	muscle	muscle	NN
cord-015021-pol2qm74	1082	7	and	and	CC
cord-015021-pol2qm74	1082	8	lung	lung	NN
cord-015021-pol2qm74	1082	9	injury	injury	NN
cord-015021-pol2qm74	1082	10	.	.	.
cord-015021-pol2qm74	1083	1	Muscle	muscle	NN
cord-015021-pol2qm74	1083	2	and	and	CC
cord-015021-pol2qm74	1083	3	lung	lung	NN
cord-015021-pol2qm74	1083	4	vascular	vascular	JJ
cord-015021-pol2qm74	1083	5	permeability	permeability	NN
cord-015021-pol2qm74	1083	6	decreased	decrease	VBD
cord-015021-pol2qm74	1083	7	in	in	IN
cord-015021-pol2qm74	1083	8	anti	anti	JJ
cord-015021-pol2qm74	1083	9	-	-	JJ
cord-015021-pol2qm74	1083	10	TNFct	TNFct	NNP
cord-015021-pol2qm74	1083	11	treated	treat	VBN
cord-015021-pol2qm74	1083	12	rats	rat	NNS
cord-015021-pol2qm74	1083	13	by	by	IN
cord-015021-pol2qm74	1083	14	41	41	CD
cord-015021-pol2qm74	1083	15	%	%	NN
cord-015021-pol2qm74	1083	16	and	and	CC
cord-015021-pol2qm74	1083	17	74	74	CD
cord-015021-pol2qm74	1083	18	%	%	NN
cord-015021-pol2qm74	1083	19	respectively	respectively	RB
cord-015021-pol2qm74	1083	20	and	and	CC
cord-015021-pol2qm74	1083	21	MPO	MPO	NNP
cord-015021-pol2qm74	1083	22	was	be	VBD
cord-015021-pol2qm74	1083	23	reduced	reduce	VBN
cord-015021-pol2qm74	1083	24	by	by	IN
cord-015021-pol2qm74	1083	25	72	72	CD
cord-015021-pol2qm74	1083	26	%	%	NN
cord-015021-pol2qm74	1083	27	and	and	CC
cord-015021-pol2qm74	1083	28	83	83	CD
cord-015021-pol2qm74	1083	29	%	%	NN
cord-015021-pol2qm74	1083	30	.	.	.
cord-015021-pol2qm74	1084	1	AntML-1	AntML-1	NNP
cord-015021-pol2qm74	1084	2	yielded	yield	VBD
cord-015021-pol2qm74	1084	3	a	a	DT
cord-015021-pol2qm74	1084	4	protection	protection	NN
cord-015021-pol2qm74	1084	5	in	in	IN
cord-015021-pol2qm74	1084	6	muscle	muscle	NN
cord-015021-pol2qm74	1084	7	and	and	CC
cord-015021-pol2qm74	1084	8	lung	lung	NN
cord-015021-pol2qm74	1084	9	vascular	vascular	JJ
cord-015021-pol2qm74	1084	10	permeability	permeability	NN
cord-015021-pol2qm74	1084	11	of	of	IN
cord-015021-pol2qm74	1084	12	24.7	24.7	CD
cord-015021-pol2qm74	1084	13	°	°	NNS
cord-015021-pol2qm74	1084	14	,4	,4	NNS
cord-015021-pol2qm74	1084	15	and	and	CC
cord-015021-pol2qm74	1084	16	52.4	52.4	CD
cord-015021-pol2qm74	1084	17	%	%	NN
cord-015021-pol2qm74	1084	18	respectively	respectively	RB
cord-015021-pol2qm74	1084	19	whereas	whereas	IN
cord-015021-pol2qm74	1084	20	muscle	muscle	NN
cord-015021-pol2qm74	1084	21	MPO	MPO	NNP
cord-015021-pol2qm74	1084	22	was	be	VBD
cord-015021-pol2qm74	1084	23	reduced	reduce	VBN
cord-015021-pol2qm74	1084	24	by	by	IN
cord-015021-pol2qm74	1084	25	46.4	46.4	CD
cord-015021-pol2qm74	1084	26	%	%	NN
cord-015021-pol2qm74	1084	27	and	and	CC
cord-015021-pol2qm74	1084	28	lung	lung	NN
cord-015021-pol2qm74	1084	29	MPO	MPO	NNP
cord-015021-pol2qm74	1084	30	by	by	IN
cord-015021-pol2qm74	1084	31	25.9	25.9	CD
cord-015021-pol2qm74	1084	32	°	°	NNS
cord-015021-pol2qm74	1084	33	,4	,4	NN
cord-015021-pol2qm74	1084	34	.	.	.
cord-015021-pol2qm74	1085	1	These	these	DT
cord-015021-pol2qm74	1085	2	results	result	NNS
cord-015021-pol2qm74	1085	3	were	be	VBD
cord-015021-pol2qm74	1085	4	confirmed	confirm	VBN
cord-015021-pol2qm74	1085	5	by	by	IN
cord-015021-pol2qm74	1085	6	the	the	DT
cord-015021-pol2qm74	1085	7	use	use	NN
cord-015021-pol2qm74	1085	8	of	of	IN
cord-015021-pol2qm74	1085	9	soluble	soluble	JJ
cord-015021-pol2qm74	1085	10	TNF~	tnf~	CD
cord-015021-pol2qm74	1085	11	receptor	receptor	NN
cord-015021-pol2qm74	1085	12	and	and	CC
cord-015021-pol2qm74	1085	13	IL	IL	NNP
cord-015021-pol2qm74	1085	14	-	-	:
cord-015021-pol2qm74	1085	15	I	-PRON-	PRP
cord-015021-pol2qm74	1085	16	receptor	receptor	NN
cord-015021-pol2qm74	1085	17	antagonist	antagonist	NN
cord-015021-pol2qm74	1085	18	(	(	-LRB-
cord-015021-pol2qm74	1085	19	IL	IL	NNP
cord-015021-pol2qm74	1085	20	-	-	HYPH
cord-015021-pol2qm74	1085	21	IRa	IRa	NNP
cord-015021-pol2qm74	1085	22	)	)	-RRB-
cord-015021-pol2qm74	1085	23	.	.	.
cord-015021-pol2qm74	1086	1	When	when	WRB
cord-015021-pol2qm74	1086	2	ICAM	ICAM	NNP
cord-015021-pol2qm74	1086	3	-	-	HYPH
cord-015021-pol2qm74	1086	4	I	-PRON-	PRP
cord-015021-pol2qm74	1086	5	expression	expression	NN
cord-015021-pol2qm74	1086	6	in	in	IN
cord-015021-pol2qm74	1086	7	vivo	vivo	NN
cord-015021-pol2qm74	1086	8	was	be	VBD
cord-015021-pol2qm74	1086	9	examined	examine	VBN
cord-015021-pol2qm74	1086	10	using	use	VBG
cord-015021-pol2qm74	1086	11	125Mabeled	125mabele	VBN
cord-015021-pol2qm74	1086	12	antMCAM	antMCAM	NNP
cord-015021-pol2qm74	1086	13	-	-	HYPH
cord-015021-pol2qm74	1086	14	I	I	NNP
cord-015021-pol2qm74	1086	15	,	,	,
cord-015021-pol2qm74	1086	16	constititive	constititive	JJ
cord-015021-pol2qm74	1086	17	expression	expression	NN
cord-015021-pol2qm74	1086	18	of	of	IN
cord-015021-pol2qm74	1086	19	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1086	20	was	be	VBD
cord-015021-pol2qm74	1086	21	evident	evident	JJ
cord-015021-pol2qm74	1086	22	only	only	RB
cord-015021-pol2qm74	1086	23	in	in	IN
cord-015021-pol2qm74	1086	24	lung	lung	NN
cord-015021-pol2qm74	1086	25	but	but	CC
cord-015021-pol2qm74	1086	26	not	not	RB
cord-015021-pol2qm74	1086	27	in	in	IN
cord-015021-pol2qm74	1086	28	muscle	muscle	NN
cord-015021-pol2qm74	1086	29	.	.	.
cord-015021-pol2qm74	1087	1	During	during	IN
cord-015021-pol2qm74	1087	2	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1087	3	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1087	4	expression	expression	NN
cord-015021-pol2qm74	1087	5	increased	increase	VBN
cord-015021-pol2qm74	1087	6	by	by	IN
cord-015021-pol2qm74	1087	7	98.2	98.2	CD
cord-015021-pol2qm74	1087	8	%	%	NN
cord-015021-pol2qm74	1087	9	.	.	.
cord-015021-pol2qm74	1088	1	Treatment	treatment	NN
cord-015021-pol2qm74	1088	2	with	with	IN
cord-015021-pol2qm74	1088	3	anti	anti	JJ
cord-015021-pol2qm74	1088	4	-	-	JJ
cord-015021-pol2qm74	1088	5	TNFcx	tnfcx	JJ
cord-015021-pol2qm74	1088	6	or	or	CC
cord-015021-pol2qm74	1088	7	IL	IL	NNP
cord-015021-pol2qm74	1088	8	-	-	HYPH
cord-015021-pol2qm74	1088	9	IRa	IRa	NNP
cord-015021-pol2qm74	1088	10	reduced	reduce	VBD
cord-015021-pol2qm74	1088	11	ICAM	ICAM	NNP
cord-015021-pol2qm74	1088	12	-	-	:
cord-015021-pol2qm74	1088	13	I	-PRON-	PRP
cord-015021-pol2qm74	1088	14	upregulation	upregulation	NN
cord-015021-pol2qm74	1088	15	by	by	IN
cord-015021-pol2qm74	1088	16	73.9	73.9	CD
cord-015021-pol2qm74	1088	17	°	°	NN
cord-015021-pol2qm74	1088	18	,4	,4	NN
cord-015021-pol2qm74	1088	19	and	and	CC
cord-015021-pol2qm74	1088	20	74.8	74.8	CD
cord-015021-pol2qm74	1088	21	%	%	NN
cord-015021-pol2qm74	1088	22	respectively	respectively	RB
cord-015021-pol2qm74	1088	23	.	.	.
cord-015021-pol2qm74	1089	1	Frozen	frozen	JJ
cord-015021-pol2qm74	1089	2	sections	section	NNS
cord-015021-pol2qm74	1089	3	of	of	IN
cord-015021-pol2qm74	1089	4	normal	normal	JJ
cord-015021-pol2qm74	1089	5	rat	rat	NN
cord-015021-pol2qm74	1089	6	lung	lung	NN
cord-015021-pol2qm74	1089	7	revealed	reveal	VBD
cord-015021-pol2qm74	1089	8	no	no	DT
cord-015021-pol2qm74	1089	9	evidence	evidence	NN
cord-015021-pol2qm74	1089	10	of	of	IN
cord-015021-pol2qm74	1089	11	E	e	NN
cord-015021-pol2qm74	1089	12	-	-	NN
cord-015021-pol2qm74	1089	13	selectin	selectin	JJ
cord-015021-pol2qm74	1089	14	expression	expression	NN
cord-015021-pol2qm74	1089	15	,	,	,
cord-015021-pol2qm74	1089	16	whereas	whereas	IN
cord-015021-pol2qm74	1089	17	lung	lung	NN
cord-015021-pol2qm74	1089	18	sections	section	NNS
cord-015021-pol2qm74	1089	19	obtained	obtain	VBN
cord-015021-pol2qm74	1089	20	after	after	IN
cord-015021-pol2qm74	1089	21	ischemia	ischemia	NN
cord-015021-pol2qm74	1089	22	and	and	CC
cord-015021-pol2qm74	1089	23	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1089	24	immunhistochemically	immunhistochemically	RB
cord-015021-pol2qm74	1089	25	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	1089	26	expression	expression	NN
cord-015021-pol2qm74	1089	27	of	of	IN
cord-015021-pol2qm74	1089	28	E	e	NN
cord-015021-pol2qm74	1089	29	-	-	NN
cord-015021-pol2qm74	1089	30	sdectin	sdectin	JJ
cord-015021-pol2qm74	1089	31	.	.	.
cord-015021-pol2qm74	1090	1	Lungs	lung	NNS
cord-015021-pol2qm74	1090	2	from	from	IN
cord-015021-pol2qm74	1090	3	rats	rat	NNS
cord-015021-pol2qm74	1090	4	pretreated	pretreate	VBN
cord-015021-pol2qm74	1090	5	with	with	IN
cord-015021-pol2qm74	1090	6	anti	anti	JJ
cord-015021-pol2qm74	1090	7	-	-	JJ
cord-015021-pol2qm74	1090	8	TNFct	TNFct	NNP
cord-015021-pol2qm74	1090	9	were	be	VBD
cord-015021-pol2qm74	1090	10	negative	negative	JJ
cord-015021-pol2qm74	1090	11	for	for	IN
cord-015021-pol2qm74	1090	12	E	e	NN
cord-015021-pol2qm74	1090	13	-	-	NN
cord-015021-pol2qm74	1090	14	selectin	selectin	JJ
cord-015021-pol2qm74	1090	15	staining	staining	NN
cord-015021-pol2qm74	1090	16	.	.	.
cord-015021-pol2qm74	1091	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	1091	2	data	datum	NNS
cord-015021-pol2qm74	1091	3	indicate	indicate	VBP
cord-015021-pol2qm74	1091	4	a	a	DT
cord-015021-pol2qm74	1091	5	role	role	NN
cord-015021-pol2qm74	1091	6	for	for	IN
cord-015021-pol2qm74	1091	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	1091	8	in	in	IN
cord-015021-pol2qm74	1091	9	the	the	DT
cord-015021-pol2qm74	1091	10	upregulation	upregulation	NN
cord-015021-pol2qm74	1091	11	of	of	IN
cord-015021-pol2qm74	1091	12	adhesion	adhesion	NN
cord-015021-pol2qm74	1091	13	molecules	molecule	NNS
cord-015021-pol2qm74	1091	14	in	in	IN
cord-015021-pol2qm74	1091	15	ischemia	ischemia	NN
cord-015021-pol2qm74	1091	16	/	/	SYM
cord-015021-pol2qm74	1091	17	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1091	18	injury	injury	NN
cord-015021-pol2qm74	1091	19	.	.	.
cord-015021-pol2qm74	1092	1	Adherence	adherence	NN
cord-015021-pol2qm74	1092	2	of	of	IN
cord-015021-pol2qm74	1092	3	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1092	4	to	to	IN
cord-015021-pol2qm74	1092	5	the	the	DT
cord-015021-pol2qm74	1092	6	coronary	coronary	JJ
cord-015021-pol2qm74	1092	7	endothelium	endothelium	NN
cord-015021-pol2qm74	1092	8	is	be	VBZ
cord-015021-pol2qm74	1092	9	associated	associate	VBN
cord-015021-pol2qm74	1092	10	with	with	IN
cord-015021-pol2qm74	1092	11	significant	significant	JJ
cord-015021-pol2qm74	1092	12	myocardial	myocardial	JJ
cord-015021-pol2qm74	1092	13	injury	injury	NN
cord-015021-pol2qm74	1092	14	following	follow	VBG
cord-015021-pol2qm74	1092	15	90	90	CD
cord-015021-pol2qm74	1092	16	min	min	NN
cord-015021-pol2qm74	1092	17	of	of	IN
cord-015021-pol2qm74	1092	18	ischemia	ischemia	NN
cord-015021-pol2qm74	1092	19	(	(	-LRB-
cord-015021-pol2qm74	1092	20	MI	MI	NNP
cord-015021-pol2qm74	1092	21	)	)	-RRB-
cord-015021-pol2qm74	1092	22	and	and	CC
cord-015021-pol2qm74	1092	23	4.5	4.5	CD
cord-015021-pol2qm74	1092	24	h	h	NN
cord-015021-pol2qm74	1092	25	of	of	IN
cord-015021-pol2qm74	1092	26	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1092	27	(	(	-LRB-
cord-015021-pol2qm74	1092	28	R	r	NN
cord-015021-pol2qm74	1092	29	)	)	-RRB-
cord-015021-pol2qm74	1092	30	.	.	.
cord-015021-pol2qm74	1093	1	P	p	NN
cord-015021-pol2qm74	1093	2	-	-	HYPH
cord-015021-pol2qm74	1093	3	selectin	selectin	NNP
cord-015021-pol2qm74	1093	4	is	be	VBZ
cord-015021-pol2qm74	1093	5	expressed	express	VBN
cord-015021-pol2qm74	1093	6	by	by	IN
cord-015021-pol2qm74	1093	7	activated	activate	VBN
cord-015021-pol2qm74	1093	8	endothelial	endothelial	JJ
cord-015021-pol2qm74	1093	9	ceils	ceil	NNS
cord-015021-pol2qm74	1093	10	and	and	CC
cord-015021-pol2qm74	1093	11	platelets	platelet	NNS
cord-015021-pol2qm74	1093	12	within	within	IN
cord-015021-pol2qm74	1093	13	10	10	CD
cord-015021-pol2qm74	1093	14	min	min	NN
cord-015021-pol2qm74	1093	15	and	and	CC
cord-015021-pol2qm74	1093	16	tethers	tether	NNS
cord-015021-pol2qm74	1093	17	polymorphonuclear	polymorphonuclear	NNP
cord-015021-pol2qm74	1093	18	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1093	19	(	(	-LRB-
cord-015021-pol2qm74	1093	20	PMNs	PMNs	NNP
cord-015021-pol2qm74	1093	21	)	)	-RRB-
cord-015021-pol2qm74	1093	22	to	to	IN
cord-015021-pol2qm74	1093	23	the	the	DT
cord-015021-pol2qm74	1093	24	endothelium	endothelium	NN
cord-015021-pol2qm74	1093	25	.	.	.
cord-015021-pol2qm74	1094	1	We	-PRON-	PRP
cord-015021-pol2qm74	1094	2	examined	examine	VBD
cord-015021-pol2qm74	1094	3	the	the	DT
cord-015021-pol2qm74	1094	4	cardioprotective	cardioprotective	JJ
cord-015021-pol2qm74	1094	5	effects	effect	NNS
cord-015021-pol2qm74	1094	6	of	of	IN
cord-015021-pol2qm74	1094	7	a	a	DT
cord-015021-pol2qm74	1094	8	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1094	9	antibody	antibody	NN
cord-015021-pol2qm74	1094	10	(	(	-LRB-
cord-015021-pol2qm74	1094	11	MAb	MAb	NNS
cord-015021-pol2qm74	1094	12	)	)	-RRB-
cord-015021-pol2qm74	1094	13	designated	designate	VBD
cord-015021-pol2qm74	1094	14	PB1.3	pb1.3	NN
cord-015021-pol2qm74	1094	15	to	to	IN
cord-015021-pol2qm74	1094	16	P	p	NN
cord-015021-pol2qm74	1094	17	-	-	HYPH
cord-015021-pol2qm74	1094	18	selectin	selectin	NN
cord-015021-pol2qm74	1094	19	in	in	IN
cord-015021-pol2qm74	1094	20	a	a	DT
cord-015021-pol2qm74	1094	21	feline	feline	JJ
cord-015021-pol2qm74	1094	22	model	model	NN
cord-015021-pol2qm74	1094	23	of	of	IN
cord-015021-pol2qm74	1094	24	MI+R.	MI+R.	NNS
cord-015021-pol2qm74	1094	25	PB	PB	NNP
cord-015021-pol2qm74	1094	26	1.3	1.3	CD
cord-015021-pol2qm74	1094	27	(	(	-LRB-
cord-015021-pol2qm74	1094	28	1	1	CD
cord-015021-pol2qm74	1094	29	mg	mg	NNP
cord-015021-pol2qm74	1094	30	/	/	SYM
cord-015021-pol2qm74	1094	31	kg	kg	NNP
cord-015021-pol2qm74	1094	32	)	)	-RRB-
cord-015021-pol2qm74	1094	33	administered	administer	VBD
cord-015021-pol2qm74	1094	34	80	80	CD
cord-015021-pol2qm74	1094	35	rain	rain	NN
cord-015021-pol2qm74	1094	36	post	post	NN
cord-015021-pol2qm74	1094	37	-	-	JJ
cord-015021-pol2qm74	1094	38	occlusion	occlusion	NN
cord-015021-pol2qm74	1094	39	(	(	-LRB-
cord-015021-pol2qm74	1094	40	10	10	CD
cord-015021-pol2qm74	1094	41	min	min	NN
cord-015021-pol2qm74	1094	42	prior	prior	RB
cord-015021-pol2qm74	1094	43	to	to	IN
cord-015021-pol2qm74	1094	44	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1094	45	)	)	-RRB-
cord-015021-pol2qm74	1094	46	significantly	significantly	RB
cord-015021-pol2qm74	1094	47	attenuated	attenuate	VBN
cord-015021-pol2qm74	1094	48	myocardial	myocardial	JJ
cord-015021-pol2qm74	1094	49	necrosis	necrosis	NN
cord-015021-pol2qm74	1094	50	compared	compare	VBN
cord-015021-pol2qm74	1094	51	to	to	IN
cord-015021-pol2qm74	1094	52	a	a	DT
cord-015021-pol2qm74	1094	53	non	non	JJ
cord-015021-pol2qm74	1094	54	-	-	JJ
cord-015021-pol2qm74	1094	55	blocking	blocking	JJ
cord-015021-pol2qm74	1094	56	MAb	MAb	NNS
cord-015021-pol2qm74	1094	57	(	(	-LRB-
cord-015021-pol2qm74	1094	58	NBP1.6	NBP1.6	NNP
cord-015021-pol2qm74	1094	59	)	)	-RRB-
cord-015021-pol2qm74	1094	60	for	for	IN
cord-015021-pol2qm74	1094	61	P	p	NN
cord-015021-pol2qm74	1094	62	-	-	HYPH
cord-015021-pol2qm74	1094	63	selectin	selectin	NNP
cord-015021-pol2qm74	1094	64	(	(	-LRB-
cord-015021-pol2qm74	1094	65	15	15	CD
cord-015021-pol2qm74	1094	66	+	+	SYM
cord-015021-pol2qm74	1094	67	3	3	CD
cord-015021-pol2qm74	1094	68	vs	vs	IN
cord-015021-pol2qm74	1094	69	33	33	CD
cord-015021-pol2qm74	1094	70	+	+	SYM
cord-015021-pol2qm74	1094	71	5	5	CD
cord-015021-pol2qm74	1094	72	%	%	NN
cord-015021-pol2qm74	1094	73	of	of	IN
cord-015021-pol2qm74	1094	74	area	area	NN
cord-015021-pol2qm74	1094	75	-	-	HYPH
cord-015021-pol2qm74	1094	76	at	at	IN
cord-015021-pol2qm74	1094	77	-	-	HYPH
cord-015021-pol2qm74	1094	78	risk	risk	NN
cord-015021-pol2qm74	1094	79	,	,	,
cord-015021-pol2qm74	1094	80	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	1094	81	)	)	-RRB-
cord-015021-pol2qm74	1094	82	.	.	.
cord-015021-pol2qm74	1095	1	Endothelial	endothelial	JJ
cord-015021-pol2qm74	1095	2	dependent	dependent	JJ
cord-015021-pol2qm74	1095	3	relaxation	relaxation	NN
cord-015021-pol2qm74	1095	4	to	to	IN
cord-015021-pol2qm74	1095	5	acetylcholine	acetylcholine	NN
cord-015021-pol2qm74	1095	6	was	be	VBD
cord-015021-pol2qm74	1095	7	also	also	RB
cord-015021-pol2qm74	1095	8	significantly	significantly	RB
cord-015021-pol2qm74	1095	9	preserved	preserve	VBN
cord-015021-pol2qm74	1095	10	in	in	IN
cord-015021-pol2qm74	1095	11	ischemic	ischemic	JJ
cord-015021-pol2qm74	1095	12	-	-	HYPH
cord-015021-pol2qm74	1095	13	reperfused	reperfused	JJ
cord-015021-pol2qm74	1095	14	coronary	coronary	JJ
cord-015021-pol2qm74	1095	15	arteries	artery	NNS
cord-015021-pol2qm74	1095	16	isolated	isolate	VBN
cord-015021-pol2qm74	1095	17	from	from	IN
cord-015021-pol2qm74	1095	18	cats	cat	NNS
cord-015021-pol2qm74	1095	19	treated	treat	VBN
cord-015021-pol2qm74	1095	20	with	with	IN
cord-015021-pol2qm74	1095	21	PB	PB	NNP
cord-015021-pol2qm74	1095	22	1.3	1.3	CD
cord-015021-pol2qm74	1095	23	compared	compare	VBN
cord-015021-pol2qm74	1095	24	to	to	IN
cord-015021-pol2qm74	1095	25	NBP1.6	NBP1.6	NNP
cord-015021-pol2qm74	1095	26	(	(	-LRB-
cord-015021-pol2qm74	1095	27	67	67	CD
cord-015021-pol2qm74	1095	28	+	+	SYM
cord-015021-pol2qm74	1095	29	6	6	CD
cord-015021-pol2qm74	1095	30	vs	vs	IN
cord-015021-pol2qm74	1095	31	11	11	CD
cord-015021-pol2qm74	1095	32	+	+	SYM
cord-015021-pol2qm74	1095	33	3	3	CD
cord-015021-pol2qm74	1095	34	,	,	,
cord-015021-pol2qm74	1095	35	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	1095	36	)	)	-RRB-
cord-015021-pol2qm74	1095	37	.	.	.
cord-015021-pol2qm74	1096	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	1096	2	,	,	,
cord-015021-pol2qm74	1096	3	PMN	PMN	NNP
cord-015021-pol2qm74	1096	4	adherence	adherence	NN
cord-015021-pol2qm74	1096	5	to	to	IN
cord-015021-pol2qm74	1096	6	ischemic	ischemic	JJ
cord-015021-pol2qm74	1096	7	-	-	HYPH
cord-015021-pol2qm74	1096	8	reperfused	reperfused	JJ
cord-015021-pol2qm74	1096	9	coronary	coronary	JJ
cord-015021-pol2qm74	1096	10	endothelium	endothelium	NN
cord-015021-pol2qm74	1096	11	was	be	VBD
cord-015021-pol2qm74	1096	12	significantly	significantly	RB
cord-015021-pol2qm74	1096	13	attenuated	attenuate	VBN
cord-015021-pol2qm74	1096	14	in	in	IN
cord-015021-pol2qm74	1096	15	PB1.3	PB1.3	NNP
cord-015021-pol2qm74	1096	16	treated	treat	VBN
cord-015021-pol2qm74	1096	17	cats	cat	NNS
cord-015021-pol2qm74	1096	18	(	(	-LRB-
cord-015021-pol2qm74	1096	19	64	64	CD
cord-015021-pol2qm74	1096	20	+	+	SYM
cord-015021-pol2qm74	1096	21	7	7	CD
cord-015021-pol2qm74	1096	22	vs	vs	IN
cord-015021-pol2qm74	1096	23	136	136	CD
cord-015021-pol2qm74	1096	24	+	+	SYM
cord-015021-pol2qm74	1096	25	12	12	CD
cord-015021-pol2qm74	1096	26	PMNs	pmn	NNS
cord-015021-pol2qm74	1096	27	/	/	SYM
cord-015021-pol2qm74	1096	28	mm	mm	NN
cord-015021-pol2qm74	1096	29	z	z	NNP
cord-015021-pol2qm74	1096	30	,	,	,
cord-015021-pol2qm74	1096	31	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	1096	32	)	)	-RRB-
cord-015021-pol2qm74	1096	33	.	.	.
cord-015021-pol2qm74	1097	1	Also	also	RB
cord-015021-pol2qm74	1097	2	,	,	,
cord-015021-pol2qm74	1097	3	normal	normal	JJ
cord-015021-pol2qm74	1097	4	coronary	coronary	JJ
cord-015021-pol2qm74	1097	5	endothelium	endothelium	NN
cord-015021-pol2qm74	1097	6	activated	activate	VBN
cord-015021-pol2qm74	1097	7	with	with	IN
cord-015021-pol2qm74	1097	8	thrombin	thrombin	NN
cord-015021-pol2qm74	1097	9	(	(	-LRB-
cord-015021-pol2qm74	1097	10	2	2	CD
cord-015021-pol2qm74	1097	11	U	U	NNP
cord-015021-pol2qm74	1097	12	/	/	SYM
cord-015021-pol2qm74	1097	13	mt	mt	NNP
cord-015021-pol2qm74	1097	14	)	)	-RRB-
cord-015021-pol2qm74	1097	15	had	have	VBD
cord-015021-pol2qm74	1097	16	increased	increase	VBN
cord-015021-pol2qm74	1097	17	PMN	PMN	NNP
cord-015021-pol2qm74	1097	18	adherence	adherence	NN
cord-015021-pol2qm74	1097	19	under	under	IN
cord-015021-pol2qm74	1097	20	conditions	condition	NNS
cord-015021-pol2qm74	1097	21	of	of	IN
cord-015021-pol2qm74	1097	22	shear	shear	NN
cord-015021-pol2qm74	1097	23	stress	stress	NN
cord-015021-pol2qm74	1097	24	,	,	,
cord-015021-pol2qm74	1097	25	an	an	DT
cord-015021-pol2qm74	1097	26	effect	effect	NN
cord-015021-pol2qm74	1097	27	which	which	WDT
cord-015021-pol2qm74	1097	28	was	be	VBD
cord-015021-pol2qm74	1097	29	significantly	significantly	RB
cord-015021-pol2qm74	1097	30	(	(	-LRB-
cord-015021-pol2qm74	1097	31	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	1097	32	)	)	-RRB-
cord-015021-pol2qm74	1097	33	blocked	block	VBN
cord-015021-pol2qm74	1097	34	by	by	IN
cord-015021-pol2qm74	1097	35	PB1.3	PB1.3	NNP
cord-015021-pol2qm74	1097	36	,	,	,
cord-015021-pol2qm74	1097	37	but	but	CC
cord-015021-pol2qm74	1097	38	not	not	RB
cord-015021-pol2qm74	1097	39	by	by	IN
cord-015021-pol2qm74	1097	40	NBP1.6	NBP1.6	NNP
cord-015021-pol2qm74	1098	1	.	.	.
cord-015021-pol2qm74	1099	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	1099	2	,	,	,
cord-015021-pol2qm74	1099	3	P	p	NN
cord-015021-pol2qm74	1099	4	-	-	HYPH
cord-015021-pol2qm74	1099	5	selectin	selectin	NNP
cord-015021-pol2qm74	1099	6	is	be	VBZ
cord-015021-pol2qm74	1099	7	markedly	markedly	RB
cord-015021-pol2qm74	1099	8	upregulated	upregulate	VBN
cord-015021-pol2qm74	1099	9	10	10	CD
cord-015021-pol2qm74	1099	10	-	-	SYM
cord-015021-pol2qm74	1099	11	20	20	CD
cord-015021-pol2qm74	1099	12	min	min	NN
cord-015021-pol2qm74	1099	13	post	post	NN
cord-015021-pol2qm74	1099	14	-	-	NN
cord-015021-pol2qm74	1099	15	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1099	16	in	in	IN
cord-015021-pol2qm74	1099	17	coronary	coronary	JJ
cord-015021-pol2qm74	1099	18	arterial	arterial	JJ
cord-015021-pol2qm74	1099	19	and	and	CC
cord-015021-pol2qm74	1099	20	venous	venous	JJ
cord-015021-pol2qm74	1099	21	endothelinm	endothelinm	NNP
cord-015021-pol2qm74	1099	22	.	.	.
cord-015021-pol2qm74	1100	1	Similar	similar	JJ
cord-015021-pol2qm74	1100	2	results	result	NNS
cord-015021-pol2qm74	1100	3	were	be	VBD
cord-015021-pol2qm74	1100	4	obtained	obtain	VBN
cord-015021-pol2qm74	1100	5	in	in	IN
cord-015021-pol2qm74	1100	6	a	a	DT
cord-015021-pol2qm74	1100	7	rat	rat	NN
cord-015021-pol2qm74	1100	8	model	model	NN
cord-015021-pol2qm74	1100	9	of	of	IN
cord-015021-pol2qm74	1100	10	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	1100	11	ischemia	ischemia	NN
cord-015021-pol2qm74	1100	12	/	/	SYM
cord-015021-pol2qm74	1100	13	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1100	14	,	,	,
cord-015021-pol2qm74	1100	15	including	include	VBG
cord-015021-pol2qm74	1100	16	upregulation	upregulation	NN
cord-015021-pol2qm74	1100	17	of	of	IN
cord-015021-pol2qm74	1100	18	P	p	NN
cord-015021-pol2qm74	1100	19	-	-	HYPH
cord-015021-pol2qm74	1100	20	selectin	selectin	NNP
cord-015021-pol2qm74	1100	21	on	on	IN
cord-015021-pol2qm74	1100	22	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	1100	23	vascular	vascular	JJ
cord-015021-pol2qm74	1100	24	endothelium	endothelium	NN
cord-015021-pol2qm74	1100	25	.	.	.
cord-015021-pol2qm74	1101	1	These	these	DT
cord-015021-pol2qm74	1101	2	results	result	NNS
cord-015021-pol2qm74	1101	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	1101	4	that	that	IN
cord-015021-pol2qm74	1101	5	tethering	tethering	NN
cord-015021-pol2qm74	1101	6	of	of	IN
cord-015021-pol2qm74	1101	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1101	8	to	to	IN
cord-015021-pol2qm74	1101	9	endethelium	endethelium	NNP
cord-015021-pol2qm74	1101	10	by	by	IN
cord-015021-pol2qm74	1101	11	P	p	NN
cord-015021-pol2qm74	1101	12	-	-	HYPH
cord-015021-pol2qm74	1101	13	selectin	selectin	NNP
cord-015021-pol2qm74	1101	14	is	be	VBZ
cord-015021-pol2qm74	1101	15	an	an	DT
cord-015021-pol2qm74	1101	16	important	important	JJ
cord-015021-pol2qm74	1101	17	early	early	JJ
cord-015021-pol2qm74	1101	18	consequence	consequence	NN
cord-015021-pol2qm74	1101	19	of	of	IN
cord-015021-pol2qm74	1101	20	reperfusien	reperfusien	NNP
cord-015021-pol2qm74	1101	21	injury	injury	NN
cord-015021-pol2qm74	1101	22	,	,	,
cord-015021-pol2qm74	1101	23	and	and	CC
cord-015021-pol2qm74	1101	24	a	a	DT
cord-015021-pol2qm74	1101	25	specific	specific	JJ
cord-015021-pol2qm74	1101	26	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1101	27	antibody	antibody	NN
cord-015021-pol2qm74	1101	28	to	to	IN
cord-015021-pol2qm74	1101	29	P	p	NN
cord-015021-pol2qm74	1101	30	-	-	HYPH
cord-015021-pol2qm74	1101	31	selectin	selectin	NNP
cord-015021-pol2qm74	1101	32	exerts	exert	VBZ
cord-015021-pol2qm74	1101	33	significant	significant	JJ
cord-015021-pol2qm74	1101	34	endothelial	endothelial	JJ
cord-015021-pol2qm74	1101	35	preservation	preservation	NN
cord-015021-pol2qm74	1101	36	and	and	CC
cord-015021-pol2qm74	1101	37	cardioprotection	cardioprotection	NN
cord-015021-pol2qm74	1101	38	in	in	IN
cord-015021-pol2qm74	1101	39	ischemia	ischemia	NN
cord-015021-pol2qm74	1101	40	and	and	CC
cord-015021-pol2qm74	1101	41	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1101	42	states	state	NNS
cord-015021-pol2qm74	1101	43	.	.	.
cord-015021-pol2qm74	1102	1	As	as	IN
cord-015021-pol2qm74	1102	2	recent	recent	JJ
cord-015021-pol2qm74	1102	3	interest	interest	NN
cord-015021-pol2qm74	1102	4	has	have	VBZ
cord-015021-pol2qm74	1102	5	increased	increase	VBN
cord-015021-pol2qm74	1102	6	in	in	IN
cord-015021-pol2qm74	1102	7	the	the	DT
cord-015021-pol2qm74	1102	8	role	role	NN
cord-015021-pol2qm74	1102	9	of	of	IN
cord-015021-pol2qm74	1102	10	extracellular	extracellular	JJ
cord-015021-pol2qm74	1102	11	matrix	matrix	NN
cord-015021-pol2qm74	1102	12	proteins	protein	NNS
cord-015021-pol2qm74	1102	13	in	in	IN
cord-015021-pol2qm74	1102	14	inflammation	inflammation	NN
cord-015021-pol2qm74	1102	15	,	,	,
cord-015021-pol2qm74	1102	16	we	-PRON-	PRP
cord-015021-pol2qm74	1102	17	examined	examine	VBD
cord-015021-pol2qm74	1102	18	the	the	DT
cord-015021-pol2qm74	1102	19	role	role	NN
cord-015021-pol2qm74	1102	20	and	and	CC
cord-015021-pol2qm74	1102	21	relationship	relationship	NN
cord-015021-pol2qm74	1102	22	of	of	IN
cord-015021-pol2qm74	1102	23	laminin	laminin	NN
cord-015021-pol2qm74	1102	24	and	and	CC
cord-015021-pol2qm74	1102	25	fibronectin	fibronectin	NN
cord-015021-pol2qm74	1102	26	to	to	IN
cord-015021-pol2qm74	1102	27	the	the	DT
cord-015021-pol2qm74	1102	28	processes	process	NNS
cord-015021-pol2qm74	1102	29	of	of	IN
cord-015021-pol2qm74	1102	30	cell	cell	NN
cord-015021-pol2qm74	1102	31	infiltration	infiltration	NN
cord-015021-pol2qm74	1102	32	in	in	IN
cord-015021-pol2qm74	1102	33	a	a	DT
cord-015021-pol2qm74	1102	34	rat	rat	NN
cord-015021-pol2qm74	1102	35	model	model	NN
cord-015021-pol2qm74	1102	36	of	of	IN
cord-015021-pol2qm74	1102	37	heart	heart	NN
cord-015021-pol2qm74	1102	38	isografts	isograft	NNS
cord-015021-pol2qm74	1102	39	.	.	.
cord-015021-pol2qm74	1103	1	Changes	change	NNS
cord-015021-pol2qm74	1103	2	occurring	occur	VBG
cord-015021-pol2qm74	1103	3	in	in	IN
cord-015021-pol2qm74	1103	4	this	this	DT
cord-015021-pol2qm74	1103	5	system	system	NN
cord-015021-pol2qm74	1103	6	are	be	VBP
cord-015021-pol2qm74	1103	7	on	on	IN
cord-015021-pol2qm74	1103	8	a	a	DT
cord-015021-pol2qm74	1103	9	nonimmunological	nonimmunological	JJ
cord-015021-pol2qm74	1103	10	basis	basis	NN
cord-015021-pol2qm74	1103	11	and	and	CC
cord-015021-pol2qm74	1103	12	may	may	MD
cord-015021-pol2qm74	1103	13	be	be	VB
cord-015021-pol2qm74	1103	14	an	an	DT
cord-015021-pol2qm74	1103	15	effect	effect	NN
cord-015021-pol2qm74	1103	16	of	of	IN
cord-015021-pol2qm74	1103	17	the	the	DT
cord-015021-pol2qm74	1103	18	initial	initial	JJ
cord-015021-pol2qm74	1103	19	surgical	surgical	JJ
cord-015021-pol2qm74	1103	20	manipulation	manipulation	NN
cord-015021-pol2qm74	1103	21	and	and	CC
cord-015021-pol2qm74	1103	22	the	the	DT
cord-015021-pol2qm74	1103	23	warm	warm	JJ
cord-015021-pol2qm74	1103	24	and	and	CC
cord-015021-pol2qm74	1103	25	cold	cold	JJ
cord-015021-pol2qm74	1103	26	ischemic	ischemic	JJ
cord-015021-pol2qm74	1103	27	times	time	NNS
cord-015021-pol2qm74	1103	28	of	of	IN
cord-015021-pol2qm74	1103	29	transplantation	transplantation	NN
cord-015021-pol2qm74	1103	30	.	.	.
cord-015021-pol2qm74	1104	1	Lewis	Lewis	NNP
cord-015021-pol2qm74	1104	2	(	(	-LRB-
cord-015021-pol2qm74	1104	3	LEW	LEW	NNP
cord-015021-pol2qm74	1104	4	)	)	-RRB-
cord-015021-pol2qm74	1104	5	donor	donor	NN
cord-015021-pol2qm74	1104	6	hearts	heart	NNS
cord-015021-pol2qm74	1104	7	were	be	VBD
cord-015021-pol2qm74	1104	8	transplanted	transplant	VBN
cord-015021-pol2qm74	1104	9	into	into	IN
cord-015021-pol2qm74	1104	10	LEW	LEW	NNP
cord-015021-pol2qm74	1104	11	recipients	recipient	NNS
cord-015021-pol2qm74	1104	12	,	,	,
cord-015021-pol2qm74	1104	13	naive	naive	JJ
cord-015021-pol2qm74	1104	14	LEW	LEW	NNP
cord-015021-pol2qm74	1104	15	acted	act	VBD
cord-015021-pol2qm74	1104	16	as	as	IN
cord-015021-pol2qm74	1104	17	naive	naive	JJ
cord-015021-pol2qm74	1104	18	controls	control	NNS
cord-015021-pol2qm74	1104	19	(	(	-LRB-
cord-015021-pol2qm74	1104	20	NC	NC	NNP
cord-015021-pol2qm74	1104	21	)	)	-RRB-
cord-015021-pol2qm74	1104	22	.	.	.
cord-015021-pol2qm74	1105	1	Grafts	graft	NNS
cord-015021-pol2qm74	1105	2	were	be	VBD
cord-015021-pol2qm74	1105	3	harvested	harvest	VBN
cord-015021-pol2qm74	1105	4	2	2	CD
cord-015021-pol2qm74	1105	5	,	,	,
cord-015021-pol2qm74	1105	6	4	4	CD
cord-015021-pol2qm74	1105	7	,	,	,
cord-015021-pol2qm74	1105	8	8	8	CD
cord-015021-pol2qm74	1105	9	,	,	,
cord-015021-pol2qm74	1105	10	16	16	CD
cord-015021-pol2qm74	1105	11	,	,	,
cord-015021-pol2qm74	1105	12	24	24	CD
cord-015021-pol2qm74	1105	13	,	,	,
cord-015021-pol2qm74	1105	14	48	48	CD
cord-015021-pol2qm74	1105	15	,	,	,
cord-015021-pol2qm74	1105	16	72	72	CD
cord-015021-pol2qm74	1105	17	,	,	,
cord-015021-pol2qm74	1105	18	120	120	CD
cord-015021-pol2qm74	1105	19	and	and	CC
cord-015021-pol2qm74	1105	20	168h	168h	CD
cord-015021-pol2qm74	1105	21	after	after	IN
cord-015021-pol2qm74	1105	22	transplantation	transplantation	NN
cord-015021-pol2qm74	1105	23	(	(	-LRB-
cord-015021-pol2qm74	1105	24	n=6	n=6	JJ
cord-015021-pol2qm74	1105	25	/	/	SYM
cord-015021-pol2qm74	1105	26	time	time	NN
cord-015021-pol2qm74	1105	27	point	point	NN
cord-015021-pol2qm74	1105	28	)	)	-RRB-
cord-015021-pol2qm74	1105	29	.	.	.
cord-015021-pol2qm74	1106	1	Snap	snap	VB
cord-015021-pol2qm74	1106	2	frozen	frozen	JJ
cord-015021-pol2qm74	1106	3	sections	section	NNS
cord-015021-pol2qm74	1106	4	of	of	IN
cord-015021-pol2qm74	1106	5	organs	organ	NNS
cord-015021-pol2qm74	1106	6	were	be	VBD
cord-015021-pol2qm74	1106	7	stained	stain	VBN
cord-015021-pol2qm74	1106	8	for	for	IN
cord-015021-pol2qm74	1106	9	CD-4	CD-4	NNP
cord-015021-pol2qm74	1106	10	(	(	-LRB-
cord-015021-pol2qm74	1106	11	W3/25	W3/25	NNP
cord-015021-pol2qm74	1106	12	)	)	-RRB-
cord-015021-pol2qm74	1106	13	,	,	.
cord-015021-pol2qm74	1107	1	CD-8	CD-8	NNP
cord-015021-pol2qm74	1108	1	(	(	-LRB-
cord-015021-pol2qm74	1108	2	OX8	OX8	NNP
cord-015021-pol2qm74	1108	3	)	)	-RRB-
cord-015021-pol2qm74	1108	4	,	,	,
cord-015021-pol2qm74	1108	5	T	T	NNP
cord-015021-pol2qm74	1108	6	-	-	HYPH
cord-015021-pol2qm74	1108	7	lymphecytes	lymphecytes	NNPS
cord-015021-pol2qm74	1108	8	(	(	-LRB-
cord-015021-pol2qm74	1108	9	TL	TL	NNP
cord-015021-pol2qm74	1108	10	)	)	-RRB-
cord-015021-pol2qm74	1108	11	(	(	-LRB-
cord-015021-pol2qm74	1108	12	OX-19	OX-19	NNP
cord-015021-pol2qm74	1108	13	)	)	-RRB-
cord-015021-pol2qm74	1108	14	,	,	,
cord-015021-pol2qm74	1108	15	macrophages	macrophage	NNS
cord-015021-pol2qm74	1108	16	(	(	-LRB-
cord-015021-pol2qm74	1108	17	ED1	ED1	NNP
cord-015021-pol2qm74	1108	18	,	,	,
cord-015021-pol2qm74	1108	19	ED2	ED2	NNP
cord-015021-pol2qm74	1108	20	)	)	-RRB-
cord-015021-pol2qm74	1108	21	,	,	,
cord-015021-pol2qm74	1108	22	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1108	23	(	(	-LRB-
cord-015021-pol2qm74	1108	24	PMN	pmn	NN
cord-015021-pol2qm74	1108	25	)	)	-RRB-
cord-015021-pol2qm74	1108	26	(	(	-LRB-
cord-015021-pol2qm74	1108	27	MOM	mom	NN
cord-015021-pol2qm74	1108	28	)	)	-RRB-
cord-015021-pol2qm74	1108	29	,	,	,
cord-015021-pol2qm74	1108	30	ICAM	ICAM	NNP
cord-015021-pol2qm74	1108	31	-	-	HYPH
cord-015021-pol2qm74	1108	32	I	I	NNP
cord-015021-pol2qm74	1108	33	(	(	-LRB-
cord-015021-pol2qm74	1108	34	IAP29	IAP29	NNP
cord-015021-pol2qm74	1108	35	)	)	-RRB-
cord-015021-pol2qm74	1108	36	,	,	,
cord-015021-pol2qm74	1108	37	laminin	laminin	NN
cord-015021-pol2qm74	1108	38	and	and	CC
cord-015021-pol2qm74	1108	39	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	1108	40	.	.	.
cord-015021-pol2qm74	1109	1	Results	result	NNS
cord-015021-pol2qm74	1109	2	were	be	VBD
cord-015021-pol2qm74	1109	3	evaluated	evaluate	VBN
cord-015021-pol2qm74	1109	4	visually	visually	RB
cord-015021-pol2qm74	1109	5	by	by	IN
cord-015021-pol2qm74	1109	6	counting	count	VBG
cord-015021-pol2qm74	1109	7	cells	cell	NNS
cord-015021-pol2qm74	1109	8	/	/	SYM
cord-015021-pol2qm74	1109	9	field	field	NN
cord-015021-pol2qm74	1109	10	of	of	IN
cord-015021-pol2qm74	1109	11	view	view	NN
cord-015021-pol2qm74	1109	12	(	(	-LRB-
cord-015021-pol2qm74	1109	13	CF	CF	NNP
cord-015021-pol2qm74	1109	14	)	)	-RRB-
cord-015021-pol2qm74	1109	15	for	for	IN
cord-015021-pol2qm74	1109	16	W3/25	W3/25	NNP
cord-015021-pol2qm74	1109	17	,	,	,
cord-015021-pol2qm74	1109	18	OX8	OX8	NNP
cord-015021-pol2qm74	1109	19	,	,	,
cord-015021-pol2qm74	1109	20	OX19	OX19	NNP
cord-015021-pol2qm74	1109	21	,	,	,
cord-015021-pol2qm74	1109	22	ED1	ED1	NNP
cord-015021-pol2qm74	1109	23	,	,	,
cord-015021-pol2qm74	1109	24	ED2	ED2	NNP
cord-015021-pol2qm74	1109	25	and	and	CC
cord-015021-pol2qm74	1109	26	MOM	MOM	NNP
cord-015021-pol2qm74	1109	27	,	,	,
cord-015021-pol2qm74	1109	28	staining	stain	VBG
cord-015021-pol2qm74	1109	29	for	for	IN
cord-015021-pol2qm74	1109	30	ICAM1	ICAM1	NNP
cord-015021-pol2qm74	1109	31	,	,	,
cord-015021-pol2qm74	1109	32	Lain	Lain	NNP
cord-015021-pol2qm74	1109	33	and	and	CC
cord-015021-pol2qm74	1109	34	Fib	Fib	NNP
cord-015021-pol2qm74	1109	35	was	be	VBD
cord-015021-pol2qm74	1109	36	assessed	assess	VBN
cord-015021-pol2qm74	1109	37	visually	visually	RB
cord-015021-pol2qm74	1109	38	using	use	VBG
cord-015021-pol2qm74	1109	39	a	a	DT
cord-015021-pol2qm74	1109	40	scale	scale	NN
cord-015021-pol2qm74	1109	41	(	(	-LRB-
cord-015021-pol2qm74	1109	42	VE=0	VE=0	NNP
cord-015021-pol2qm74	1109	43	-	-	HYPH
cord-015021-pol2qm74	1109	44	10	10	CD
cord-015021-pol2qm74	1109	45	)	)	-RRB-
cord-015021-pol2qm74	1109	46	.	.	.
cord-015021-pol2qm74	1110	1	As	as	RB
cord-015021-pol2qm74	1110	2	early	early	RB
cord-015021-pol2qm74	1110	3	as	as	IN
cord-015021-pol2qm74	1110	4	2h	2h	CD
cord-015021-pol2qm74	1110	5	after	after	IN
cord-015021-pol2qm74	1110	6	transplantation	transplantation	NN
cord-015021-pol2qm74	1110	7	,	,	,
cord-015021-pol2qm74	1110	8	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	1110	9	and	and	CC
cord-015021-pol2qm74	1110	10	laminin	laminin	NN
cord-015021-pol2qm74	1110	11	expression	expression	NN
cord-015021-pol2qm74	1110	12	increased	increase	VBD
cord-015021-pol2qm74	1110	13	in	in	IN
cord-015021-pol2qm74	1110	14	I	-PRON-	PRP
cord-015021-pol2qm74	1110	15	,	,	,
cord-015021-pol2qm74	1110	16	peaking	peak	VBG
cord-015021-pol2qm74	1110	17	8h	8h	CD
cord-015021-pol2qm74	1110	18	after	after	IN
cord-015021-pol2qm74	1110	19	transplantation	transplantation	NN
cord-015021-pol2qm74	1110	20	(	(	-LRB-
cord-015021-pol2qm74	1110	21	VE=	VE=	NNP
cord-015021-pol2qm74	1110	22	4.5	4.5	CD
cord-015021-pol2qm74	1110	23	;	;	:
cord-015021-pol2qm74	1110	24	NC	NC	NNP
cord-015021-pol2qm74	1110	25	:	:	:
cord-015021-pol2qm74	1110	26	VE	VE	NNP
cord-015021-pol2qm74	1110	27	=	=	SYM
cord-015021-pol2qm74	1110	28	I.5	i.5	NN
cord-015021-pol2qm74	1110	29	)	)	-RRB-
cord-015021-pol2qm74	1110	30	.	.	.
cord-015021-pol2qm74	1111	1	At	at	IN
cord-015021-pol2qm74	1111	2	16	16	CD
cord-015021-pol2qm74	1111	3	and	and	CC
cord-015021-pol2qm74	1111	4	24h	24h	NNS
cord-015021-pol2qm74	1111	5	in	in	IN
cord-015021-pol2qm74	1111	6	I	-PRON-	PRP
cord-015021-pol2qm74	1111	7	,	,	,
cord-015021-pol2qm74	1111	8	on	on	IN
cord-015021-pol2qm74	1111	9	both	both	DT
cord-015021-pol2qm74	1111	10	vessels	vessel	NNS
cord-015021-pol2qm74	1111	11	and	and	CC
cord-015021-pol2qm74	1111	12	interstitial	interstitial	JJ
cord-015021-pol2qm74	1111	13	cells	cell	NNS
cord-015021-pol2qm74	1111	14	laminin	laminin	NN
cord-015021-pol2qm74	1111	15	and	and	CC
cord-015021-pol2qm74	1111	16	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	1111	17	expression	expression	NN
cord-015021-pol2qm74	1111	18	had	have	VBD
cord-015021-pol2qm74	1111	19	declined	decline	VBN
cord-015021-pol2qm74	1111	20	to	to	TO
cord-015021-pol2qm74	1111	21	baseline	baseline	VB
cord-015021-pol2qm74	1111	22	(	(	-LRB-
cord-015021-pol2qm74	1111	23	VE	VE	NNP
cord-015021-pol2qm74	1111	24	=	=	SYM
cord-015021-pol2qm74	1111	25	I.5	I.5	NNP
cord-015021-pol2qm74	1111	26	)	)	-RRB-
cord-015021-pol2qm74	1111	27	but	but	CC
cord-015021-pol2qm74	1111	28	rose	rise	VBD
cord-015021-pol2qm74	1111	29	again	again	RB
cord-015021-pol2qm74	1111	30	at	at	IN
cord-015021-pol2qm74	1111	31	48h	48h	NNS
cord-015021-pol2qm74	1111	32	,	,	,
cord-015021-pol2qm74	1111	33	peaking	peak	VBG
cord-015021-pol2qm74	1111	34	at	at	IN
cord-015021-pol2qm74	1111	35	72h	72h	NNP
cord-015021-pol2qm74	1111	36	(	(	-LRB-
cord-015021-pol2qm74	1111	37	VE=4	VE=4	NNP
cord-015021-pol2qm74	1111	38	)	)	-RRB-
cord-015021-pol2qm74	1111	39	and	and	CC
cord-015021-pol2qm74	1111	40	remaining	remain	VBG
cord-015021-pol2qm74	1111	41	elevated	elevate	VBN
cord-015021-pol2qm74	1111	42	thereafter	thereafter	RB
cord-015021-pol2qm74	1111	43	(	(	-LRB-
cord-015021-pol2qm74	1111	44	VE=3	VE=3	NNP
cord-015021-pol2qm74	1111	45	)	)	-RRB-
cord-015021-pol2qm74	1111	46	.	.	.
cord-015021-pol2qm74	1112	1	The	the	DT
cord-015021-pol2qm74	1112	2	high	high	JJ
cord-015021-pol2qm74	1112	3	expression	expression	NN
cord-015021-pol2qm74	1112	4	at	at	IN
cord-015021-pol2qm74	1112	5	8h	8h	NNP
cord-015021-pol2qm74	1112	6	correlated	correlate	VBD
cord-015021-pol2qm74	1112	7	well	well	RB
cord-015021-pol2qm74	1112	8	with	with	IN
cord-015021-pol2qm74	1112	9	the	the	DT
cord-015021-pol2qm74	1112	10	maximal	maximal	JJ
cord-015021-pol2qm74	1112	11	PMN	PMN	NNP
cord-015021-pol2qm74	1112	12	infiltration	infiltration	NN
cord-015021-pol2qm74	1112	13	at	at	IN
cord-015021-pol2qm74	1112	14	that	that	DT
cord-015021-pol2qm74	1112	15	time	time	NN
cord-015021-pol2qm74	1113	1	(	(	-LRB-
cord-015021-pol2qm74	1113	2	CF=6	CF=6	NNP
cord-015021-pol2qm74	1113	3	)	)	-RRB-
cord-015021-pol2qm74	1113	4	in	in	IN
cord-015021-pol2qm74	1113	5	I	-PRON-	PRP
cord-015021-pol2qm74	1113	6	returning	return	VBG
cord-015021-pol2qm74	1113	7	to	to	IN
cord-015021-pol2qm74	1113	8	baseline	baseline	NN
cord-015021-pol2qm74	1113	9	at	at	IN
cord-015021-pol2qm74	1113	10	24h	24h	NNS
cord-015021-pol2qm74	1113	11	(	(	-LRB-
cord-015021-pol2qm74	1113	12	CF=0.5	CF=0.5	NNP
cord-015021-pol2qm74	1113	13	)	)	-RRB-
cord-015021-pol2qm74	1113	14	and	and	CC
cord-015021-pol2qm74	1113	15	thereafter	thereafter	RB
cord-015021-pol2qm74	1113	16	.	.	.
cord-015021-pol2qm74	1114	1	The	the	DT
cord-015021-pol2qm74	1114	2	second	second	JJ
cord-015021-pol2qm74	1114	3	peak	peak	NN
cord-015021-pol2qm74	1114	4	at	at	IN
cord-015021-pol2qm74	1114	5	72h	72h	NNS
cord-015021-pol2qm74	1114	6	correlated	correlate	VBN
cord-015021-pol2qm74	1114	7	with	with	IN
cord-015021-pol2qm74	1114	8	the	the	DT
cord-015021-pol2qm74	1114	9	onset	onset	NN
cord-015021-pol2qm74	1114	10	of	of	IN
cord-015021-pol2qm74	1114	11	macrophage	macrophage	NN
cord-015021-pol2qm74	1114	12	and	and	CC
cord-015021-pol2qm74	1114	13	T	t	NN
cord-015021-pol2qm74	1114	14	-	-	HYPH
cord-015021-pol2qm74	1114	15	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	1114	16	infiltration	infiltration	NN
cord-015021-pol2qm74	1114	17	.	.	.
cord-015021-pol2qm74	1115	1	Thus	thus	RB
cord-015021-pol2qm74	1115	2	,	,	,
cord-015021-pol2qm74	1115	3	laminin	laminin	NN
cord-015021-pol2qm74	1115	4	and	and	CC
cord-015021-pol2qm74	1115	5	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	1115	6	seem	seem	VBP
cord-015021-pol2qm74	1115	7	to	to	TO
cord-015021-pol2qm74	1115	8	guide	guide	VB
cord-015021-pol2qm74	1115	9	leucocyte	leucocyte	JJ
cord-015021-pol2qm74	1115	10	infiltration	infiltration	NN
cord-015021-pol2qm74	1115	11	following	follow	VBG
cord-015021-pol2qm74	1115	12	graft	graft	NN
cord-015021-pol2qm74	1115	13	ischemia	ischemia	NN
cord-015021-pol2qm74	1115	14	during	during	IN
cord-015021-pol2qm74	1115	15	the	the	DT
cord-015021-pol2qm74	1115	16	time	time	NN
cord-015021-pol2qm74	1115	17	of	of	IN
cord-015021-pol2qm74	1115	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1115	19	.	.	.
cord-015021-pol2qm74	1116	1	Background	background	NN
cord-015021-pol2qm74	1116	2	.	.	.
cord-015021-pol2qm74	1117	1	Reperfusion	reperfusion	NN
cord-015021-pol2qm74	1117	2	of	of	IN
cord-015021-pol2qm74	1117	3	ischemic	ischemic	JJ
cord-015021-pol2qm74	1117	4	kidneys	kidney	NNS
cord-015021-pol2qm74	1117	5	with	with	IN
cord-015021-pol2qm74	1117	6	xenogeneic	xenogeneic	NNS
cord-015021-pol2qm74	1117	7	blood	blood	NN
cord-015021-pol2qm74	1117	8	leads	lead	NNS
cord-015021-pol2qm74	1117	9	to	to	IN
cord-015021-pol2qm74	1117	10	activation	activation	NN
cord-015021-pol2qm74	1117	11	of	of	IN
cord-015021-pol2qm74	1117	12	endothelial	endothelial	JJ
cord-015021-pol2qm74	1117	13	cells	cell	NNS
cord-015021-pol2qm74	1117	14	and	and	CC
cord-015021-pol2qm74	1117	15	circulating	circulate	VBG
cord-015021-pol2qm74	1117	16	leucocytes	leucocyte	NNS
cord-015021-pol2qm74	1117	17	with	with	IN
cord-015021-pol2qm74	1117	18	the	the	DT
cord-015021-pol2qm74	1117	19	final	final	JJ
cord-015021-pol2qm74	1117	20	consequence	consequence	NN
cord-015021-pol2qm74	1117	21	of	of	IN
cord-015021-pol2qm74	1117	22	microvascular	microvascular	JJ
cord-015021-pol2qm74	1117	23	thrombosis	thrombosis	NN
cord-015021-pol2qm74	1117	24	.	.	.
cord-015021-pol2qm74	1118	1	In	in	IN
cord-015021-pol2qm74	1118	2	concordant	concordant	JJ
cord-015021-pol2qm74	1118	3	systems	system	NNS
cord-015021-pol2qm74	1118	4	,	,	,
cord-015021-pol2qm74	1118	5	the	the	DT
cord-015021-pol2qm74	1118	6	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1118	7	of	of	IN
cord-015021-pol2qm74	1118	8	rejection	rejection	NN
cord-015021-pol2qm74	1118	9	can	can	MD
cord-015021-pol2qm74	1118	10	be	be	VB
cord-015021-pol2qm74	1118	11	studied	study	VBN
cord-015021-pol2qm74	1118	12	due	due	IN
cord-015021-pol2qm74	1118	13	to	to	IN
cord-015021-pol2qm74	1118	14	cross	cross	NN
cord-015021-pol2qm74	1118	15	-	-	NN
cord-015021-pol2qm74	1118	16	reactivity	reactivity	NN
cord-015021-pol2qm74	1118	17	of	of	IN
cord-015021-pol2qm74	1118	18	mediators	mediator	NNS
cord-015021-pol2qm74	1118	19	with	with	IN
cord-015021-pol2qm74	1118	20	anti	anti	JJ
cord-015021-pol2qm74	1118	21	-	-	JJ
cord-015021-pol2qm74	1118	22	human	human	JJ
cord-015021-pol2qm74	1118	23	monoclona~	monoclona~	NNS
cord-015021-pol2qm74	1118	24	antibodies	antibody	NNS
cord-015021-pol2qm74	1118	25	.	.	.
cord-015021-pol2qm74	1119	1	Aim	Aim	NNP
cord-015021-pol2qm74	1119	2	of	of	IN
cord-015021-pol2qm74	1119	3	the	the	DT
cord-015021-pol2qm74	1119	4	study	study	NN
cord-015021-pol2qm74	1119	5	.	.	.
cord-015021-pol2qm74	1120	1	To	to	TO
cord-015021-pol2qm74	1120	2	obtain	obtain	VB
cord-015021-pol2qm74	1120	3	information	information	NN
cord-015021-pol2qm74	1120	4	about	about	IN
cord-015021-pol2qm74	1120	5	the	the	DT
cord-015021-pol2qm74	1120	6	kinetics	kinetic	NNS
cord-015021-pol2qm74	1120	7	of	of	IN
cord-015021-pol2qm74	1120	8	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	1120	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	1120	10	and	and	CC
cord-015021-pol2qm74	1120	11	production	production	NN
cord-015021-pol2qm74	1120	12	of	of	IN
cord-015021-pol2qm74	1120	13	soluble	soluble	JJ
cord-015021-pol2qm74	1120	14	adhesion	adhesion	NN
cord-015021-pol2qm74	1120	15	molecules	molecule	NNS
cord-015021-pol2qm74	1120	16	in	in	IN
cord-015021-pol2qm74	1120	17	the	the	DT
cord-015021-pol2qm74	1120	18	acute	acute	JJ
cord-015021-pol2qm74	1120	19	phase	phase	NN
cord-015021-pol2qm74	1120	20	of	of	IN
cord-015021-pol2qm74	1120	21	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1120	22	,	,	,
cord-015021-pol2qm74	1120	23	eight	eight	CD
cord-015021-pol2qm74	1120	24	kidneys	kidney	NNS
cord-015021-pol2qm74	1120	25	from	from	IN
cord-015021-pol2qm74	1120	26	rhesus	rhesu	NNS
cord-015021-pol2qm74	1120	27	monkeys	monkey	NNS
cord-015021-pol2qm74	1120	28	were	be	VBD
cord-015021-pol2qm74	1120	29	perfused	perfuse	VBN
cord-015021-pol2qm74	1120	30	ex	ex	NN
cord-015021-pol2qm74	1120	31	-	-	NN
cord-015021-pol2qm74	1120	32	vivo	vivo	JJ
cord-015021-pol2qm74	1120	33	with	with	IN
cord-015021-pol2qm74	1120	34	human	human	JJ
cord-015021-pol2qm74	1120	35	blood	blood	NN
cord-015021-pol2qm74	1120	36	(	(	-LRB-
cord-015021-pol2qm74	1120	37	group	group	NN
cord-015021-pol2qm74	1120	38	B	B	NNP
cord-015021-pol2qm74	1120	39	/	/	SYM
cord-015021-pol2qm74	1120	40	O	O	NNP
cord-015021-pol2qm74	1120	41	)	)	-RRB-
cord-015021-pol2qm74	1120	42	for	for	IN
cord-015021-pol2qm74	1120	43	one	one	CD
cord-015021-pol2qm74	1120	44	hour	hour	NN
cord-015021-pol2qm74	1120	45	in	in	IN
cord-015021-pol2qm74	1120	46	a	a	DT
cord-015021-pol2qm74	1120	47	closed	closed	JJ
cord-015021-pol2qm74	1120	48	system	system	NN
cord-015021-pol2qm74	1120	49	.	.	.
cord-015021-pol2qm74	1121	1	Blood	blood	NN
cord-015021-pol2qm74	1121	2	levels	level	NNS
cord-015021-pol2qm74	1121	3	of	of	IN
cord-015021-pol2qm74	1121	4	IL	IL	NNP
cord-015021-pol2qm74	1121	5	-	-	HYPH
cord-015021-pol2qm74	1121	6	lb	lb	NNP
cord-015021-pol2qm74	1121	7	,	,	,
cord-015021-pol2qm74	1121	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	1121	9	,	,	,
cord-015021-pol2qm74	1121	10	TNF	TNF	NNP
cord-015021-pol2qm74	1121	11	-	-	HYPH
cord-015021-pol2qm74	1121	12	a	a	DT
cord-015021-pol2qm74	1121	13	,	,	,
cord-015021-pol2qm74	1121	14	soluble	soluble	JJ
cord-015021-pol2qm74	1121	15	ICAM	ICAM	NNP
cord-015021-pol2qm74	1121	16	and	and	CC
cord-015021-pol2qm74	1121	17	E	E	NNP
cord-015021-pol2qm74	1121	18	-	-	:
cord-015021-pol2qm74	1121	19	Selectin	Selectin	NNP
cord-015021-pol2qm74	1121	20	were	be	VBD
cord-015021-pol2qm74	1121	21	measured	measure	VBN
cord-015021-pol2qm74	1121	22	in	in	IN
cord-015021-pol2qm74	1121	23	ELISA	ELISA	NNP
cord-015021-pol2qm74	1121	24	-	-	HYPH
cord-015021-pol2qm74	1121	25	technique	technique	NN
cord-015021-pol2qm74	1121	26	under	under	IN
cord-015021-pol2qm74	1121	27	steady	steady	JJ
cord-015021-pol2qm74	1121	28	-	-	HYPH
cord-015021-pol2qm74	1121	29	state	state	NN
cord-015021-pol2qm74	1121	30	conditions	condition	NNS
cord-015021-pol2qm74	1121	31	.	.	.
cord-015021-pol2qm74	1122	1	Results	result	NNS
cord-015021-pol2qm74	1122	2	.	.	.
cord-015021-pol2qm74	1123	1	Cytokine	cytokine	NN
cord-015021-pol2qm74	1123	2	levels	level	NNS
cord-015021-pol2qm74	1123	3	rose	rise	VBD
cord-015021-pol2qm74	1123	4	significantly	significantly	RB
cord-015021-pol2qm74	1123	5	within	within	IN
cord-015021-pol2qm74	1123	6	the	the	DT
cord-015021-pol2qm74	1123	7	60minute	60minute	JJ
cord-015021-pol2qm74	1123	8	interval	interval	NN
cord-015021-pol2qm74	1123	9	(	(	-LRB-
cord-015021-pol2qm74	1123	10	IL	IL	NNP
cord-015021-pol2qm74	1123	11	-	-	HYPH
cord-015021-pol2qm74	1123	12	lb	lb	NN
cord-015021-pol2qm74	1123	13	:	:	:
cord-015021-pol2qm74	1123	14	6,1__+2,6	6,1__+2,6	CD
cord-015021-pol2qm74	1123	15	to	to	IN
cord-015021-pol2qm74	1123	16	161,1__+98,5	161,1__+98,5	CD
cord-015021-pol2qm74	1123	17	pg	pg	NNP
cord-015021-pol2qm74	1123	18	/	/	SYM
cord-015021-pol2qm74	1123	19	ml	ml	XX
cord-015021-pol2qm74	1123	20	;	;	:
cord-015021-pol2qm74	1123	21	IL-6:30.24	IL-6:30.24	NNP
cord-015021-pol2qm74	1123	22	-	-	HYPH
cord-015021-pol2qm74	1123	23	7,7	7,7	CD
cord-015021-pol2qm74	1123	24	to	to	IN
cord-015021-pol2qm74	1123	25	274,2__+75,8	274,2__+75,8	CD
cord-015021-pol2qm74	1123	26	pg	pg	NN
cord-015021-pol2qm74	1123	27	/	/	SYM
cord-015021-pol2qm74	1123	28	ml	ml	NN
cord-015021-pol2qm74	1123	29	;	;	:
cord-015021-pol2qm74	1123	30	TNF	TNF	NNP
cord-015021-pol2qm74	1123	31	-	-	HYPH
cord-015021-pol2qm74	1123	32	a	a	NN
cord-015021-pol2qm74	1123	33	:	:	:
cord-015021-pol2qm74	1123	34	544,2__+363,6	544,2__+363,6	CD
cord-015021-pol2qm74	1124	1	to	to	IN
cord-015021-pol2qm74	1124	2	1651,0	1651,0	CD
cord-015021-pol2qm74	1124	3	+	+	CD
cord-015021-pol2qm74	1124	4	25,7	25,7	CD
cord-015021-pol2qm74	1124	5	pg	pg	NNP
cord-015021-pol2qm74	1124	6	/	/	SYM
cord-015021-pol2qm74	1124	7	ml	ml	NN
cord-015021-pol2qm74	1124	8	;	;	:
cord-015021-pol2qm74	1124	9	p<0.05	p<0.05	CD
cord-015021-pol2qm74	1124	10	)	)	-RRB-
cord-015021-pol2qm74	1124	11	.	.	.
cord-015021-pol2qm74	1125	1	Immediately	immediately	RB
cord-015021-pol2qm74	1125	2	after	after	IN
cord-015021-pol2qm74	1125	3	the	the	DT
cord-015021-pol2qm74	1125	4	beginning	beginning	NN
cord-015021-pol2qm74	1125	5	of	of	IN
cord-015021-pol2qm74	1125	6	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1125	7	,	,	,
cord-015021-pol2qm74	1125	8	soluble	soluble	JJ
cord-015021-pol2qm74	1125	9	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1125	10	and	and	CC
cord-015021-pol2qm74	1125	11	Selectin	Selectin	NNP
cord-015021-pol2qm74	1125	12	levels	level	NNS
cord-015021-pol2qm74	1125	13	were	be	VBD
cord-015021-pol2qm74	1125	14	abnormally	abnormally	RB
cord-015021-pol2qm74	1125	15	high	high	JJ
cord-015021-pol2qm74	1125	16	and	and	CC
cord-015021-pol2qm74	1125	17	constantly	constantly	RB
cord-015021-pol2qm74	1125	18	rising	rise	VBG
cord-015021-pol2qm74	1125	19	throughout	throughout	IN
cord-015021-pol2qm74	1125	20	the	the	DT
cord-015021-pol2qm74	1125	21	observation	observation	NN
cord-015021-pol2qm74	1125	22	period	period	NN
cord-015021-pol2qm74	1125	23	,	,	,
cord-015021-pol2qm74	1125	24	reaching	reach	VBG
cord-015021-pol2qm74	1125	25	significance	significance	NN
cord-015021-pol2qm74	1125	26	at	at	IN
cord-015021-pol2qm74	1125	27	60	60	CD
cord-015021-pol2qm74	1125	28	minutes	minute	NNS
cord-015021-pol2qm74	1125	29	.	.	.
cord-015021-pol2qm74	1126	1	Discussion	discussion	NN
cord-015021-pol2qm74	1126	2	.	.	.
cord-015021-pol2qm74	1127	1	High	high	JJ
cord-015021-pol2qm74	1127	2	levels	level	NNS
cord-015021-pol2qm74	1127	3	of	of	IN
cord-015021-pol2qm74	1127	4	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	1127	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	1127	6	may	may	MD
cord-015021-pol2qm74	1127	7	lead	lead	VB
cord-015021-pol2qm74	1127	8	to	to	IN
cord-015021-pol2qm74	1127	9	an	an	DT
cord-015021-pol2qm74	1127	10	induction	induction	NN
cord-015021-pol2qm74	1127	11	of	of	IN
cord-015021-pol2qm74	1127	12	adhesion	adhesion	NN
cord-015021-pol2qm74	1127	13	molecules	molecule	NNS
cord-015021-pol2qm74	1127	14	,	,	,
cord-015021-pol2qm74	1127	15	thus	thus	RB
cord-015021-pol2qm74	1127	16	upregulating	upregulate	VBG
cord-015021-pol2qm74	1127	17	the	the	DT
cord-015021-pol2qm74	1127	18	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1127	19	-	-	HYPH
cord-015021-pol2qm74	1127	20	endothelial	endothelial	JJ
cord-015021-pol2qm74	1127	21	interaction	interaction	NN
cord-015021-pol2qm74	1127	22	in	in	IN
cord-015021-pol2qm74	1127	23	an	an	DT
cord-015021-pol2qm74	1127	24	complement	complement	NN
cord-015021-pol2qm74	1127	25	-	-	HYPH
cord-015021-pol2qm74	1127	26	independent	independent	JJ
cord-015021-pol2qm74	1127	27	mechanism	mechanism	NN
cord-015021-pol2qm74	1127	28	.	.	.
cord-015021-pol2qm74	1128	1	Specific	specific	JJ
cord-015021-pol2qm74	1128	2	pretreatment	pretreatment	NN
cord-015021-pol2qm74	1128	3	with	with	IN
cord-015021-pol2qm74	1128	4	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1128	5	antibodies	antibody	NNS
cord-015021-pol2qm74	1128	6	against	against	IN
cord-015021-pol2qm74	1128	7	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1128	8	,	,	,
cord-015021-pol2qm74	1128	9	LFA-1	LFA-1	NNP
cord-015021-pol2qm74	1128	10	or	or	CC
cord-015021-pol2qm74	1128	11	other	other	JJ
cord-015021-pol2qm74	1128	12	soluble	soluble	JJ
cord-015021-pol2qm74	1128	13	mediators	mediator	NNS
cord-015021-pol2qm74	1128	14	may	may	MD
cord-015021-pol2qm74	1128	15	be	be	VB
cord-015021-pol2qm74	1128	16	useful	useful	JJ
cord-015021-pol2qm74	1128	17	in	in	IN
cord-015021-pol2qm74	1128	18	downregulating	downregulate	VBG
cord-015021-pol2qm74	1128	19	hyperacute	hyperacute	JJ
cord-015021-pol2qm74	1128	20	rejection	rejection	NN
cord-015021-pol2qm74	1128	21	in	in	IN
cord-015021-pol2qm74	1128	22	transspecies	transspecie	NNS
cord-015021-pol2qm74	1128	23	transplantation	transplantation	NN
cord-015021-pol2qm74	1128	24	.	.	.
cord-015021-pol2qm74	1129	1	Prolonged	prolonged	JJ
cord-015021-pol2qm74	1129	2	ischemia	ischemia	NN
cord-015021-pol2qm74	1129	3	has	have	VBZ
cord-015021-pol2qm74	1129	4	been	be	VBN
cord-015021-pol2qm74	1129	5	associated	associate	VBN
cord-015021-pol2qm74	1129	6	with	with	IN
cord-015021-pol2qm74	1129	7	later	later	JJ
cord-015021-pol2qm74	1129	8	dysfunction	dysfunction	NN
cord-015021-pol2qm74	1129	9	of	of	IN
cord-015021-pol2qm74	1129	10	solid	solid	JJ
cord-015021-pol2qm74	1129	11	organs	organ	NNS
cord-015021-pol2qm74	1129	12	as	as	IN
cord-015021-pol2qm74	1129	13	it	-PRON-	PRP
cord-015021-pol2qm74	1129	14	may	may	MD
cord-015021-pol2qm74	1129	15	cause	cause	VB
cord-015021-pol2qm74	1129	16	upregulation	upregulation	NN
cord-015021-pol2qm74	1129	17	of	of	IN
cord-015021-pol2qm74	1129	18	adhesion	adhesion	NN
cord-015021-pol2qm74	1129	19	molecules	molecule	NNS
cord-015021-pol2qm74	1129	20	,	,	,
cord-015021-pol2qm74	1129	21	production	production	NN
cord-015021-pol2qm74	1129	22	of	of	IN
cord-015021-pol2qm74	1129	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	1129	24	on	on	IN
cord-015021-pol2qm74	1129	25	vascular	vascular	JJ
cord-015021-pol2qm74	1129	26	endothelium	endothelium	NN
cord-015021-pol2qm74	1129	27	and	and	CC
cord-015021-pol2qm74	1129	28	migration	migration	NN
cord-015021-pol2qm74	1129	29	of	of	IN
cord-015021-pol2qm74	1129	30	host	host	NN
cord-015021-pol2qm74	1129	31	cells	cell	NNS
cord-015021-pol2qm74	1129	32	into	into	IN
cord-015021-pol2qm74	1129	33	the	the	DT
cord-015021-pol2qm74	1129	34	graft	graft	NN
cord-015021-pol2qm74	1129	35	.	.	.
cord-015021-pol2qm74	1130	1	These	these	DT
cord-015021-pol2qm74	1130	2	early	early	JJ
cord-015021-pol2qm74	1130	3	events	event	NNS
cord-015021-pol2qm74	1130	4	may	may	MD
cord-015021-pol2qm74	1130	5	lead	lead	VB
cord-015021-pol2qm74	1130	6	to	to	IN
cord-015021-pol2qm74	1130	7	irreversible	irreversible	JJ
cord-015021-pol2qm74	1130	8	organ	organ	NN
cord-015021-pol2qm74	1130	9	injury	injury	NN
cord-015021-pol2qm74	1130	10	.	.	.
cord-015021-pol2qm74	1131	1	This	this	DT
cord-015021-pol2qm74	1131	2	study	study	NN
cord-015021-pol2qm74	1131	3	evaluates	evaluate	VBZ
cord-015021-pol2qm74	1131	4	the	the	DT
cord-015021-pol2qm74	1131	5	effects	effect	NNS
cord-015021-pol2qm74	1131	6	of	of	IN
cord-015021-pol2qm74	1131	7	global	global	JJ
cord-015021-pol2qm74	1131	8	ischemia	ischemia	NN
cord-015021-pol2qm74	1131	9	on	on	IN
cord-015021-pol2qm74	1131	10	early	early	JJ
cord-015021-pol2qm74	1131	11	immunohistological	immunohistological	JJ
cord-015021-pol2qm74	1131	12	changes	change	NNS
cord-015021-pol2qm74	1131	13	in	in	IN
cord-015021-pol2qm74	1131	14	cardiac	cardiac	JJ
cord-015021-pol2qm74	1131	15	grafts	graft	NNS
cord-015021-pol2qm74	1131	16	transplanted	transplant	VBN
cord-015021-pol2qm74	1131	17	in	in	IN
cord-015021-pol2qm74	1131	18	rats	rat	NNS
cord-015021-pol2qm74	1131	19	.	.	.
cord-015021-pol2qm74	1132	1	Isografted	isografted	JJ
cord-015021-pol2qm74	1132	2	hearts	heart	NNS
cord-015021-pol2qm74	1132	3	(	(	-LRB-
cord-015021-pol2qm74	1132	4	Lewis->Lewis	Lewis->Lewis	NNP
cord-015021-pol2qm74	1132	5	)	)	-RRB-
cord-015021-pol2qm74	1132	6	were	be	VBD
cord-015021-pol2qm74	1132	7	were	be	VBD
cord-015021-pol2qm74	1132	8	divided	divide	VBN
cord-015021-pol2qm74	1132	9	into	into	IN
cord-015021-pol2qm74	1132	10	ischemic	ischemic	JJ
cord-015021-pol2qm74	1132	11	and	and	CC
cord-015021-pol2qm74	1132	12	non	non	JJ
cord-015021-pol2qm74	1132	13	-	-	JJ
cord-015021-pol2qm74	1132	14	ischemic	ischemic	JJ
cord-015021-pol2qm74	1132	15	groups	group	NNS
cord-015021-pol2qm74	1132	16	(	(	-LRB-
cord-015021-pol2qm74	1132	17	n=30	n=30	NNP
cord-015021-pol2qm74	1132	18	/	/	SYM
cord-015021-pol2qm74	1132	19	group	group	NN
cord-015021-pol2qm74	1132	20	)	)	-RRB-
cord-015021-pol2qm74	1132	21	.	.	.
cord-015021-pol2qm74	1133	1	All	all	DT
cord-015021-pol2qm74	1133	2	donor	donor	NN
cord-015021-pol2qm74	1133	3	hearts	heart	NNS
cord-015021-pol2qm74	1133	4	were	be	VBD
cord-015021-pol2qm74	1133	5	flushed	flush	VBN
cord-015021-pol2qm74	1133	6	immediately	immediately	RB
cord-015021-pol2qm74	1133	7	with	with	IN
cord-015021-pol2qm74	1133	8	cold	cold	JJ
cord-015021-pol2qm74	1133	9	saline	saline	NN
cord-015021-pol2qm74	1133	10	.	.	.
cord-015021-pol2qm74	1134	1	Non	non	JJ
cord-015021-pol2qm74	1134	2	-	-	JJ
cord-015021-pol2qm74	1134	3	ischemic	ischemic	JJ
cord-015021-pol2qm74	1134	4	hearts	heart	NNS
cord-015021-pol2qm74	1134	5	were	be	VBD
cord-015021-pol2qm74	1134	6	then	then	RB
cord-015021-pol2qm74	1134	7	transplanted	transplant	VBN
cord-015021-pol2qm74	1134	8	within	within	IN
cord-015021-pol2qm74	1134	9	30	30	CD
cord-015021-pol2qm74	1134	10	rain	rain	NN
cord-015021-pol2qm74	1134	11	,	,	,
cord-015021-pol2qm74	1134	12	ischemic	ischemic	JJ
cord-015021-pol2qm74	1134	13	hearts	heart	NNS
cord-015021-pol2qm74	1134	14	were	be	VBD
cord-015021-pol2qm74	1134	15	stored	store	VBN
cord-015021-pol2qm74	1134	16	in	in	IN
cord-015021-pol2qm74	1134	17	cold	cold	JJ
cord-015021-pol2qm74	1134	18	Ringer	Ringer	NNP
cord-015021-pol2qm74	1134	19	's	's	POS
cord-015021-pol2qm74	1134	20	solution	solution	NN
cord-015021-pol2qm74	1134	21	for	for	IN
cord-015021-pol2qm74	1134	22	3	3	CD
cord-015021-pol2qm74	1134	23	hours	hour	NNS
cord-015021-pol2qm74	1134	24	before	before	IN
cord-015021-pol2qm74	1134	25	revascularization	revascularization	NN
cord-015021-pol2qm74	1134	26	.	.	.
cord-015021-pol2qm74	1135	1	Representative	representative	JJ
cord-015021-pol2qm74	1135	2	grafts	graft	NNS
cord-015021-pol2qm74	1135	3	were	be	VBD
cord-015021-pol2qm74	1135	4	removed	remove	VBN
cord-015021-pol2qm74	1135	5	after	after	IN
cord-015021-pol2qm74	1135	6	12	12	CD
cord-015021-pol2qm74	1135	7	.	.	.
cord-015021-pol2qm74	1136	1	24	24	CD
cord-015021-pol2qm74	1136	2	,	,	,
cord-015021-pol2qm74	1136	3	72hrs	72hrs	NN
cord-015021-pol2qm74	1136	4	,	,	,
cord-015021-pol2qm74	1136	5	10	10	CD
cord-015021-pol2qm74	1136	6	and	and	CC
cord-015021-pol2qm74	1136	7	100	100	CD
cord-015021-pol2qm74	1136	8	days	day	NNS
cord-015021-pol2qm74	1136	9	,	,	,
cord-015021-pol2qm74	1136	10	and	and	CC
cord-015021-pol2qm74	1136	11	evaluated	evaluate	VBN
cord-015021-pol2qm74	1136	12	immunohistologically	immunohistologically	RB
cord-015021-pol2qm74	1136	13	(	(	-LRB-
cord-015021-pol2qm74	1136	14	cells	cell	NNS
cord-015021-pol2qm74	1136	15	/	/	SYM
cord-015021-pol2qm74	1136	16	field	field	NN
cord-015021-pol2qm74	1136	17	of	of	IN
cord-015021-pol2qm74	1136	18	view	view	NN
cord-015021-pol2qm74	1136	19	=	=	SYM
cord-015021-pol2qm74	1136	20	C	c	NN
cord-015021-pol2qm74	1136	21	/	/	SYM
cord-015021-pol2qm74	1136	22	F	F	NNP
cord-015021-pol2qm74	1136	23	)	)	-RRB-
cord-015021-pol2qm74	1136	24	.	.	.
cord-015021-pol2qm74	1137	1	Restitution	restitution	NN
cord-015021-pol2qm74	1137	2	of	of	IN
cord-015021-pol2qm74	1137	3	ventricular	ventricular	JJ
cord-015021-pol2qm74	1137	4	activity	activity	NN
cord-015021-pol2qm74	1137	5	was	be	VBD
cord-015021-pol2qm74	1137	6	significantly	significantly	RB
cord-015021-pol2qm74	1137	7	delayed	delay	VBN
cord-015021-pol2qm74	1137	8	in	in	IN
cord-015021-pol2qm74	1137	9	ischemic	ischemic	JJ
cord-015021-pol2qm74	1137	10	grafts	graft	NNS
cord-015021-pol2qm74	1137	11	(	(	-LRB-
cord-015021-pol2qm74	1137	12	5	5	CD
cord-015021-pol2qm74	1137	13	vs	vs	IN
cord-015021-pol2qm74	1137	14	1	1	CD
cord-015021-pol2qm74	1137	15	rain	rain	NN
cord-015021-pol2qm74	1137	16	)	)	-RRB-
cord-015021-pol2qm74	1137	17	.	.	.
cord-015021-pol2qm74	1138	1	After	after	IN
cord-015021-pol2qm74	1138	2	12	12	CD
cord-015021-pol2qm74	1138	3	hrs	hrs	NN
cord-015021-pol2qm74	1138	4	,	,	,
cord-015021-pol2qm74	1138	5	all	all	DT
cord-015021-pol2qm74	1138	6	ischemic	ischemic	JJ
cord-015021-pol2qm74	1138	7	grafts	graft	NNS
cord-015021-pol2qm74	1138	8	exhibited	exhibit	VBD
cord-015021-pol2qm74	1138	9	an	an	DT
cord-015021-pol2qm74	1138	10	extensive	extensive	JJ
cord-015021-pol2qm74	1138	11	interstitial	interstitial	JJ
cord-015021-pol2qm74	1138	12	edema	edema	NN
cord-015021-pol2qm74	1138	13	,	,	,
cord-015021-pol2qm74	1138	14	declining	decline	VBG
cord-015021-pol2qm74	1138	15	slowly	slowly	RB
cord-015021-pol2qm74	1138	16	thereafter	thereafter	RB
cord-015021-pol2qm74	1138	17	.	.	.
cord-015021-pol2qm74	1139	1	At	at	IN
cord-015021-pol2qm74	1139	2	the	the	DT
cord-015021-pol2qm74	1139	3	same	same	JJ
cord-015021-pol2qm74	1139	4	time	time	NN
cord-015021-pol2qm74	1139	5	,	,	,
cord-015021-pol2qm74	1139	6	numbers	number	NNS
cord-015021-pol2qm74	1139	7	of	of	IN
cord-015021-pol2qm74	1139	8	PMN	PMN	NNP
cord-015021-pol2qm74	1139	9	peaked	peak	VBD
cord-015021-pol2qm74	1139	10	(	(	-LRB-
cord-015021-pol2qm74	1139	11	3	3	CD
cord-015021-pol2qm74	1139	12	vs	vs	IN
cord-015021-pol2qm74	1139	13	1	1	CD
cord-015021-pol2qm74	1139	14	C	C	NNP
cord-015021-pol2qm74	1139	15	/	/	SYM
cord-015021-pol2qm74	1139	16	F	F	NNP
cord-015021-pol2qm74	1139	17	in	in	IN
cord-015021-pol2qm74	1139	18	non	non	JJ
cord-015021-pol2qm74	1139	19	-	-	JJ
cord-015021-pol2qm74	1139	20	ischemic	ischemic	JJ
cord-015021-pol2qm74	1139	21	grafts	graft	NNS
cord-015021-pol2qm74	1139	22	)	)	-RRB-
cord-015021-pol2qm74	1139	23	,	,	,
cord-015021-pol2qm74	1139	24	whereas	whereas	IN
cord-015021-pol2qm74	1139	25	EDl+macrophages	edl+macrophage	NNS
cord-015021-pol2qm74	1139	26	(	(	-LRB-
cord-015021-pol2qm74	1139	27	9	9	CD
cord-015021-pol2qm74	1139	28	vs	vs	IN
cord-015021-pol2qm74	1139	29	2	2	CD
cord-015021-pol2qm74	1139	30	C	C	NNP
cord-015021-pol2qm74	1139	31	/	/	SYM
cord-015021-pol2qm74	1139	32	F	F	NNP
cord-015021-pol2qm74	1139	33	)	)	-RRB-
cord-015021-pol2qm74	1139	34	and	and	CC
cord-015021-pol2qm74	1139	35	TNFe	TNFe	NNP
cord-015021-pol2qm74	1139	36	expression	expression	NN
cord-015021-pol2qm74	1139	37	peaked	peak	VBD
cord-015021-pol2qm74	1139	38	by	by	IN
cord-015021-pol2qm74	1139	39	24hrs	24hrs	NN
cord-015021-pol2qm74	1139	40	.	.	.
cord-015021-pol2qm74	1140	1	By	by	IN
cord-015021-pol2qm74	1140	2	72	72	CD
cord-015021-pol2qm74	1140	3	hrs	hrs	NN
cord-015021-pol2qm74	1140	4	T	t	NN
cord-015021-pol2qm74	1140	5	-	-	HYPH
cord-015021-pol2qm74	1140	6	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	1140	7	began	begin	VBD
cord-015021-pol2qm74	1140	8	to	to	TO
cord-015021-pol2qm74	1140	9	enter	enter	VB
cord-015021-pol2qm74	1140	10	ischemic	ischemic	JJ
cord-015021-pol2qm74	1140	11	myocardium	myocardium	NN
cord-015021-pol2qm74	1140	12	and	and	CC
cord-015021-pol2qm74	1140	13	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1140	14	was	be	VBD
cord-015021-pol2qm74	1140	15	moderately	moderately	RB
cord-015021-pol2qm74	1140	16	increased	increase	VBN
cord-015021-pol2qm74	1140	17	.	.	.
cord-015021-pol2qm74	1141	1	After	after	IN
cord-015021-pol2qm74	1141	2	10	10	CD
cord-015021-pol2qm74	1141	3	days	day	NNS
cord-015021-pol2qm74	1141	4	cellular	cellular	JJ
cord-015021-pol2qm74	1141	5	infiltration	infiltration	NN
cord-015021-pol2qm74	1141	6	had	have	VBD
cord-015021-pol2qm74	1141	7	returned	return	VBN
cord-015021-pol2qm74	1141	8	to	to	IN
cord-015021-pol2qm74	1141	9	baseline	baseline	NN
cord-015021-pol2qm74	1141	10	,	,	,
cord-015021-pol2qm74	1141	11	and	and	CC
cord-015021-pol2qm74	1141	12	no	no	DT
cord-015021-pol2qm74	1141	13	differences	difference	NNS
cord-015021-pol2qm74	1141	14	were	be	VBD
cord-015021-pol2qm74	1141	15	seen	see	VBN
cord-015021-pol2qm74	1141	16	among	among	IN
cord-015021-pol2qm74	1141	17	both	both	DT
cord-015021-pol2qm74	1141	18	groups	group	NNS
cord-015021-pol2qm74	1141	19	after	after	IN
cord-015021-pol2qm74	1141	20	100	100	CD
cord-015021-pol2qm74	1141	21	days	day	NNS
cord-015021-pol2qm74	1141	22	.	.	.
cord-015021-pol2qm74	1142	1	Global	global	JJ
cord-015021-pol2qm74	1142	2	myocardial	myocardial	JJ
cord-015021-pol2qm74	1142	3	ischemia	ischemia	NN
cord-015021-pol2qm74	1142	4	inhibits	inhibit	VBZ
cord-015021-pol2qm74	1142	5	initial	initial	JJ
cord-015021-pol2qm74	1142	6	graft	graft	NN
cord-015021-pol2qm74	1142	7	function	function	NN
cord-015021-pol2qm74	1142	8	,	,	,
cord-015021-pol2qm74	1142	9	and	and	CC
cord-015021-pol2qm74	1142	10	engenders	engender	VBZ
cord-015021-pol2qm74	1142	11	a	a	DT
cord-015021-pol2qm74	1142	12	brisk	brisk	JJ
cord-015021-pol2qm74	1142	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1142	14	reponse	reponse	NN
cord-015021-pol2qm74	1142	15	,	,	,
cord-015021-pol2qm74	1142	16	primarily	primarily	RB
cord-015021-pol2qm74	1142	17	PMN	PMN	NNP
cord-015021-pol2qm74	1142	18	and	and	CC
cord-015021-pol2qm74	1142	19	macrophages	macrophage	NNS
cord-015021-pol2qm74	1142	20	,	,	,
cord-015021-pol2qm74	1142	21	with	with	IN
cord-015021-pol2qm74	1142	22	increased	increase	VBN
cord-015021-pol2qm74	1142	23	MHC	MHC	NNP
cord-015021-pol2qm74	1142	24	Class	Class	NNP
cord-015021-pol2qm74	1142	25	II	II	NNP
cord-015021-pol2qm74	1142	26	and	and	CC
cord-015021-pol2qm74	1142	27	cytokine	cytokine	JJ
cord-015021-pol2qm74	1142	28	expression	expression	NN
cord-015021-pol2qm74	1142	29	.	.	.
cord-015021-pol2qm74	1143	1	Leukocyte	Leukocyte	NNP
cord-015021-pol2qm74	1143	2	-endothelial	-endothelial	.
cord-015021-pol2qm74	1144	1	interactions	interaction	NNS
cord-015021-pol2qm74	1144	2	are	be	VBP
cord-015021-pol2qm74	1144	3	the	the	DT
cord-015021-pol2qm74	1144	4	result	result	NN
cord-015021-pol2qm74	1144	5	of	of	IN
cord-015021-pol2qm74	1144	6	endothelial	endothelial	JJ
cord-015021-pol2qm74	1144	7	activation	activation	NN
cord-015021-pol2qm74	1144	8	,	,	,
cord-015021-pol2qm74	1144	9	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1144	10	activation	activation	NN
cord-015021-pol2qm74	1144	11	or	or	CC
cord-015021-pol2qm74	1144	12	combination	combination	NN
cord-015021-pol2qm74	1144	13	of	of	IN
cord-015021-pol2qm74	1144	14	both	both	DT
cord-015021-pol2qm74	1144	15	,	,	,
cord-015021-pol2qm74	1144	16	which	which	WDT
cord-015021-pol2qm74	1144	17	are	be	VBP
cord-015021-pol2qm74	1144	18	accompanied	accompany	VBN
cord-015021-pol2qm74	1144	19	by	by	IN
cord-015021-pol2qm74	1144	20	nee	nee	NN
cord-015021-pol2qm74	1144	21	-	-	HYPH
cord-015021-pol2qm74	1144	22	expression	expression	NN
cord-015021-pol2qm74	1144	23	,	,	,
cord-015021-pol2qm74	1144	24	upregulation	upregulation	NN
cord-015021-pol2qm74	1144	25	or	or	CC
cord-015021-pol2qm74	1144	26	shedding	shedding	NN
cord-015021-pol2qm74	1144	27	of	of	IN
cord-015021-pol2qm74	1144	28	adhesion	adhesion	NN
cord-015021-pol2qm74	1144	29	molecules	molecule	NNS
cord-015021-pol2qm74	1144	30	(	(	-LRB-
cord-015021-pol2qm74	1144	31	Selectins	Selectins	NNPS
cord-015021-pol2qm74	1144	32	,	,	,
cord-015021-pol2qm74	1144	33	Inlegrins	Inlegrins	NNP
cord-015021-pol2qm74	1144	34	)	)	-RRB-
cord-015021-pol2qm74	1144	35	.	.	.
cord-015021-pol2qm74	1145	1	Such	such	JJ
cord-015021-pol2qm74	1145	2	interactions	interaction	NNS
cord-015021-pol2qm74	1145	3	differ	differ	VBP
cord-015021-pol2qm74	1145	4	with	with	IN
cord-015021-pol2qm74	1145	5	regard	regard	NN
cord-015021-pol2qm74	1145	6	to	to	IN
cord-015021-pol2qm74	1145	7	the	the	DT
cord-015021-pol2qm74	1145	8	stimulus	stimulus	NN
cord-015021-pol2qm74	1145	9	(	(	-LRB-
cord-015021-pol2qm74	1145	10	e.g.	e.g.	IN
cord-015021-pol2qm74	1145	11	thrombin	thrombin	NN
cord-015021-pol2qm74	1145	12	or	or	CC
cord-015021-pol2qm74	1145	13	histamine	histamine	NN
cord-015021-pol2qm74	1145	14	for	for	IN
cord-015021-pol2qm74	1145	15	P	p	NN
cord-015021-pol2qm74	1145	16	-	-	HYPH
cord-015021-pol2qm74	1145	17	selectin	selectin	NN
cord-015021-pol2qm74	1145	18	,	,	,
cord-015021-pol2qm74	1145	19	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1145	20	or	or	CC
cord-015021-pol2qm74	1145	21	TNF	TNF	NNP
cord-015021-pol2qm74	1145	22	/	/	SYM
cord-015021-pol2qm74	1145	23	IL-1	IL-1	NNP
cord-015021-pol2qm74	1145	24	for	for	IN
cord-015021-pol2qm74	1145	25	E	E	NNP
cord-015021-pol2qm74	1145	26	-	-	NN
cord-015021-pol2qm74	1145	27	selectin	selectin	NNP
cord-015021-pol2qm74	1145	28	)	)	-RRB-
cord-015021-pol2qm74	1145	29	,	,	,
cord-015021-pol2qm74	1145	30	the	the	DT
cord-015021-pol2qm74	1145	31	time	time	NN
cord-015021-pol2qm74	1145	32	course	course	NN
cord-015021-pol2qm74	1145	33	of	of	IN
cord-015021-pol2qm74	1145	34	response	response	NN
cord-015021-pol2qm74	1145	35	(	(	-LRB-
cord-015021-pol2qm74	1145	36	minutes	minute	NNS
cord-015021-pol2qm74	1145	37	versus	versus	IN
cord-015021-pol2qm74	1145	38	hours	hour	NNS
cord-015021-pol2qm74	1145	39	)	)	-RRB-
cord-015021-pol2qm74	1145	40	and	and	CC
cord-015021-pol2qm74	1145	41	the	the	DT
cord-015021-pol2qm74	1145	42	localisation	localisation	NN
cord-015021-pol2qm74	1145	43	in	in	IN
cord-015021-pol2qm74	1145	44	different	different	JJ
cord-015021-pol2qm74	1145	45	organs	organ	NNS
cord-015021-pol2qm74	1145	46	.	.	.
cord-015021-pol2qm74	1146	1	Recently	recently	RB
cord-015021-pol2qm74	1146	2	assays	assay	NNS
cord-015021-pol2qm74	1146	3	are	be	VBP
cord-015021-pol2qm74	1146	4	available	available	JJ
cord-015021-pol2qm74	1146	5	for	for	IN
cord-015021-pol2qm74	1146	6	circulating	circulate	VBG
cord-015021-pol2qm74	1146	7	soluble	soluble	JJ
cord-015021-pol2qm74	1146	8	fragments	fragment	NNS
cord-015021-pol2qm74	1146	9	of	of	IN
cord-015021-pol2qm74	1146	10	the	the	DT
cord-015021-pol2qm74	1146	11	cell	cell	NN
cord-015021-pol2qm74	1146	12	bound	bind	VBN
cord-015021-pol2qm74	1146	13	adhesion	adhesion	NN
cord-015021-pol2qm74	1146	14	molecules	molecule	NNS
cord-015021-pol2qm74	1146	15	e.g.	e.g.	RB
cord-015021-pol2qm74	1146	16	sE	sE	NNP
cord-015021-pol2qm74	1146	17	-	-	HYPH
cord-015021-pol2qm74	1146	18	seleetin	seleetin	NNP
cord-015021-pol2qm74	1146	19	was	be	VBD
cord-015021-pol2qm74	1146	20	found	find	VBN
cord-015021-pol2qm74	1146	21	to	to	TO
cord-015021-pol2qm74	1146	22	be	be	VB
cord-015021-pol2qm74	1146	23	increased	increase	VBN
cord-015021-pol2qm74	1146	24	in	in	IN
cord-015021-pol2qm74	1146	25	plasma	plasma	NN
cord-015021-pol2qm74	1146	26	concurrent	concurrent	JJ
cord-015021-pol2qm74	1146	27	with	with	IN
cord-015021-pol2qm74	1146	28	high	high	JJ
cord-015021-pol2qm74	1146	29	circulating	circulate	VBG
cord-015021-pol2qm74	1146	30	endoloxin	endoloxin	NN
cord-015021-pol2qm74	1146	31	and	and	CC
cord-015021-pol2qm74	1146	32	cytokine	cytokine	NN
cord-015021-pol2qm74	1146	33	levels	level	NNS
cord-015021-pol2qm74	1146	34	.	.	.
cord-015021-pol2qm74	1147	1	The	the	DT
cord-015021-pol2qm74	1147	2	importance	importance	NN
cord-015021-pol2qm74	1147	3	of	of	IN
cord-015021-pol2qm74	1147	4	adhesion	adhesion	NN
cord-015021-pol2qm74	1147	5	molecules	molecule	NNS
cord-015021-pol2qm74	1147	6	for	for	IN
cord-015021-pol2qm74	1147	7	the	the	DT
cord-015021-pol2qm74	1147	8	sepsis	sepsis	NN
cord-015021-pol2qm74	1147	9	event	event	NN
cord-015021-pol2qm74	1147	10	is	be	VBZ
cord-015021-pol2qm74	1147	11	evident	evident	JJ
cord-015021-pol2qm74	1147	12	,	,	,
cord-015021-pol2qm74	1147	13	while	while	IN
cord-015021-pol2qm74	1147	14	effectiveness	effectiveness	NN
cord-015021-pol2qm74	1147	15	of	of	IN
cord-015021-pol2qm74	1147	16	anti	anti	JJ
cord-015021-pol2qm74	1147	17	-	-	JJ
cord-015021-pol2qm74	1147	18	adhesion	adhesion	JJ
cord-015021-pol2qm74	1147	19	inolecu]e	inolecu]e	NN
cord-015021-pol2qm74	1147	20	therapy	therapy	NN
cord-015021-pol2qm74	1147	21	is	be	VBZ
cord-015021-pol2qm74	1147	22	controversial	controversial	JJ
cord-015021-pol2qm74	1147	23	e.g.	e.g.	IN
cord-015021-pol2qm74	1147	24	beneficial	beneficial	JJ
cord-015021-pol2qm74	1147	25	anti	anti	JJ
cord-015021-pol2qm74	1147	26	-	-	JJ
cord-015021-pol2qm74	1147	27	E	e	JJ
cord-015021-pol2qm74	1147	28	-	-	HYPH
cord-015021-pol2qm74	1147	29	selectin	selectin	JJ
cord-015021-pol2qm74	1147	30	therapy	therapy	NN
cord-015021-pol2qm74	1147	31	in	in	IN
cord-015021-pol2qm74	1147	32	baboon	baboon	NN
cord-015021-pol2qm74	1147	33	bacleremia	bacleremia	NNP
cord-015021-pol2qm74	1147	34	but	but	CC
cord-015021-pol2qm74	1147	35	deleterious	deleterious	JJ
cord-015021-pol2qm74	1147	36	effects	effect	NNS
cord-015021-pol2qm74	1147	37	of	of	IN
cord-015021-pol2qm74	1147	38	amti	amti	JJ
cord-015021-pol2qm74	1147	39	-	-	HYPH
cord-015021-pol2qm74	1147	40	CD18	CD18	NNP
cord-015021-pol2qm74	1147	41	treatment	treatment	NN
cord-015021-pol2qm74	1147	42	in	in	IN
cord-015021-pol2qm74	1147	43	the	the	DT
cord-015021-pol2qm74	1147	44	same	same	JJ
cord-015021-pol2qm74	1147	45	model	model	NN
cord-015021-pol2qm74	1147	46	.	.	.
cord-015021-pol2qm74	1148	1	In	in	IN
cord-015021-pol2qm74	1148	2	other	other	JJ
cord-015021-pol2qm74	1148	3	species	specie	NNS
cord-015021-pol2qm74	1148	4	similar	similar	JJ
cord-015021-pol2qm74	1148	5	controversial	controversial	JJ
cord-015021-pol2qm74	1148	6	results	result	NNS
cord-015021-pol2qm74	1148	7	with	with	IN
cord-015021-pol2qm74	1148	8	anti	anti	JJ
cord-015021-pol2qm74	1148	9	-	-	JJ
cord-015021-pol2qm74	1148	10	CD18	cd18	JJ
cord-015021-pol2qm74	1148	11	therapy	therapy	NN
cord-015021-pol2qm74	1148	12	in	in	IN
cord-015021-pol2qm74	1148	13	sepsis	sepsis	NN
cord-015021-pol2qm74	1148	14	were	be	VBD
cord-015021-pol2qm74	1148	15	reported	report	VBN
cord-015021-pol2qm74	1148	16	.	.	.
cord-015021-pol2qm74	1149	1	Steven	Steven	NNP
cord-015021-pol2qm74	1149	2	L.	L.	NNP
cord-015021-pol2qm74	1149	3	Kunkel	Kunkel	NNP
cord-015021-pol2qm74	1149	4	,	,	,
cord-015021-pol2qm74	1149	5	Theodore	Theodore	NNP
cord-015021-pol2qm74	1149	6	Standiford	Standiford	NNP
cord-015021-pol2qm74	1149	7	*	*	NFP
cord-015021-pol2qm74	1149	8	and	and	CC
cord-015021-pol2qm74	1149	9	Robert	Robert	NNP
cord-015021-pol2qm74	1149	10	M.	M.	NNP
cord-015021-pol2qm74	1149	11	Stricter	Stricter	NNP
cord-015021-pol2qm74	1149	12	.	.	.
cord-015021-pol2qm74	1150	1	The	the	DT
cord-015021-pol2qm74	1150	2	migration	migration	NN
cord-015021-pol2qm74	1150	3	of	of	IN
cord-015021-pol2qm74	1150	4	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1150	5	to	to	IN
cord-015021-pol2qm74	1150	6	the	the	DT
cord-015021-pol2qm74	1150	7	lung	lung	NN
cord-015021-pol2qm74	1150	8	during	during	IN
cord-015021-pol2qm74	1150	9	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	1150	10	is	be	VBZ
cord-015021-pol2qm74	1150	11	dependent	dependent	JJ
cord-015021-pol2qm74	1150	12	upon	upon	IN
cord-015021-pol2qm74	1150	13	the	the	DT
cord-015021-pol2qm74	1150	14	coordinated	coordinated	JJ
cord-015021-pol2qm74	1150	15	expression	expression	NN
cord-015021-pol2qm74	1150	16	of	of	IN
cord-015021-pol2qm74	1150	17	lung	lung	NN
cord-015021-pol2qm74	1150	18	vascular	vascular	JJ
cord-015021-pol2qm74	1150	19	adhesion	adhesion	NN
cord-015021-pol2qm74	1150	20	molecules	molecule	NNS
cord-015021-pol2qm74	1150	21	and	and	CC
cord-015021-pol2qm74	1150	22	the	the	DT
cord-015021-pol2qm74	1150	23	subsequent	subsequent	JJ
cord-015021-pol2qm74	1150	24	production	production	NN
cord-015021-pol2qm74	1150	25	of	of	IN
cord-015021-pol2qm74	1150	26	appropriate	appropriate	JJ
cord-015021-pol2qm74	1150	27	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1150	28	chemotactic	chemotactic	VBN
cord-015021-pol2qm74	1150	29	proteins	protein	NNS
cord-015021-pol2qm74	1150	30	.	.	.
cord-015021-pol2qm74	1151	1	In	in	IN
cord-015021-pol2qm74	1151	2	experimental	experimental	JJ
cord-015021-pol2qm74	1151	3	animals	animal	NNS
cord-015021-pol2qm74	1151	4	,	,	,
cord-015021-pol2qm74	1151	5	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1151	6	accumulate	accumulate	VBP
cord-015021-pol2qm74	1151	7	within	within	IN
cord-015021-pol2qm74	1151	8	the	the	DT
cord-015021-pol2qm74	1151	9	lung	lung	NN
cord-015021-pol2qm74	1151	10	soon	soon	RB
cord-015021-pol2qm74	1151	11	after	after	IN
cord-015021-pol2qm74	1151	12	the	the	DT
cord-015021-pol2qm74	1151	13	administration	administration	NN
cord-015021-pol2qm74	1151	14	of	of	IN
cord-015021-pol2qm74	1151	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1151	16	,	,	,
cord-015021-pol2qm74	1151	17	while	while	IN
cord-015021-pol2qm74	1151	18	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	1151	19	cell	cell	NN
cord-015021-pol2qm74	1151	20	infiltration	infiltration	NN
cord-015021-pol2qm74	1151	21	occurs	occur	VBZ
cord-015021-pol2qm74	1151	22	in	in	IN
cord-015021-pol2qm74	1151	23	a	a	DT
cord-015021-pol2qm74	1151	24	more	more	RBR
cord-015021-pol2qm74	1151	25	distal	distal	JJ
cord-015021-pol2qm74	1151	26	manner	manner	NN
cord-015021-pol2qm74	1151	27	.	.	.
cord-015021-pol2qm74	1152	1	A	a	DT
cord-015021-pol2qm74	1152	2	kinetic	kinetic	JJ
cord-015021-pol2qm74	1152	3	analysis	analysis	NN
cord-015021-pol2qm74	1152	4	of	of	IN
cord-015021-pol2qm74	1152	5	lung	lung	NN
cord-015021-pol2qm74	1152	6	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1152	7	levels	level	NNS
cord-015021-pol2qm74	1152	8	revealed	reveal	VBD
cord-015021-pol2qm74	1152	9	a	a	DT
cord-015021-pol2qm74	1152	10	3-fold	3-fold	CD
cord-015021-pol2qm74	1152	11	increase	increase	NN
cord-015021-pol2qm74	1152	12	in	in	IN
cord-015021-pol2qm74	1152	13	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1152	14	numbers	number	NNS
cord-015021-pol2qm74	1152	15	associated	associate	VBN
cord-015021-pol2qm74	1152	16	with	with	IN
cord-015021-pol2qm74	1152	17	dispersed	disperse	VBN
cord-015021-pol2qm74	1152	18	lullg	lullg	JJ
cord-015021-pol2qm74	1152	19	tissues	tissue	NNS
cord-015021-pol2qm74	1152	20	2	2	CD
cord-015021-pol2qm74	1152	21	hours	hour	NNS
cord-015021-pol2qm74	1152	22	after	after	IN
cord-015021-pol2qm74	1152	23	LPS	LPS	NNP
cord-015021-pol2qm74	1152	24	treatment	treatment	NN
cord-015021-pol2qm74	1152	25	,	,	,
cord-015021-pol2qm74	1152	26	while	while	IN
cord-015021-pol2qm74	1152	27	macrophage	macrophage	NN
cord-015021-pol2qm74	1152	28	levels	level	NNS
cord-015021-pol2qm74	1152	29	increased	increase	VBN
cord-015021-pol2qm74	1152	30	by	by	IN
cord-015021-pol2qm74	1152	31	4-fold	4-fold	CD
cord-015021-pol2qm74	1152	32	at	at	IN
cord-015021-pol2qm74	1152	33	the	the	DT
cord-015021-pol2qm74	1152	34	24	24	CD
cord-015021-pol2qm74	1152	35	hour	hour	NN
cord-015021-pol2qm74	1152	36	time	time	NN
cord-015021-pol2qm74	1152	37	point	point	NN
cord-015021-pol2qm74	1152	38	.	.	.
cord-015021-pol2qm74	1153	1	Thus	thus	RB
cord-015021-pol2qm74	1153	2	,	,	,
cord-015021-pol2qm74	1153	3	the	the	DT
cord-015021-pol2qm74	1153	4	recruitment	recruitment	NN
cord-015021-pol2qm74	1153	5	of	of	IN
cord-015021-pol2qm74	1153	6	different	different	JJ
cord-015021-pol2qm74	1153	7	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1153	8	populations	population	NNS
cord-015021-pol2qm74	1153	9	to	to	IN
cord-015021-pol2qm74	1153	10	the	the	DT
cord-015021-pol2qm74	1153	11	lungs	lung	NNS
cord-015021-pol2qm74	1153	12	during	during	IN
cord-015021-pol2qm74	1153	13	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	1153	14	is	be	VBZ
cord-015021-pol2qm74	1153	15	likely	likely	RB
cord-015021-pol2qm74	1153	16	directed	direct	VBN
cord-015021-pol2qm74	1153	17	by	by	IN
cord-015021-pol2qm74	1153	18	different	different	JJ
cord-015021-pol2qm74	1153	19	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1153	20	.	.	.
cord-015021-pol2qm74	1154	1	Recent	recent	JJ
cord-015021-pol2qm74	1154	2	studies	study	NNS
cord-015021-pol2qm74	1154	3	have	have	VBP
cord-015021-pol2qm74	1154	4	identified	identify	VBN
cord-015021-pol2qm74	1154	5	a	a	DT
cord-015021-pol2qm74	1154	6	supergene	supergene	JJ
cord-015021-pol2qm74	1154	7	family	family	NN
cord-015021-pol2qm74	1154	8	of	of	IN
cord-015021-pol2qm74	1154	9	small	small	JJ
cord-015021-pol2qm74	1154	10	inducible	inducible	JJ
cord-015021-pol2qm74	1154	11	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	1154	12	cytokines	cytokine	NNS
cord-015021-pol2qm74	1154	13	(	(	-LRB-
cord-015021-pol2qm74	1154	14	chemukines	chemukines	NNP
cord-015021-pol2qm74	1154	15	)	)	-RRB-
cord-015021-pol2qm74	1154	16	which	which	WDT
cord-015021-pol2qm74	1154	17	possesses	possess	VBZ
cord-015021-pol2qm74	1154	18	chemotactic	chemotactic	VBN
cord-015021-pol2qm74	1154	19	and	and	CC
cord-015021-pol2qm74	1154	20	activating	activate	VBG
cord-015021-pol2qm74	1154	21	properties	property	NNS
cord-015021-pol2qm74	1154	22	for	for	IN
cord-015021-pol2qm74	1154	23	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1154	24	.	.	.
cord-015021-pol2qm74	1155	1	The	the	DT
cord-015021-pol2qm74	1155	2	prototype	prototype	NN
cord-015021-pol2qm74	1155	3	of	of	IN
cord-015021-pol2qm74	1155	4	this	this	DT
cord-015021-pol2qm74	1155	5	family	family	NN
cord-015021-pol2qm74	1155	6	is	be	VBZ
cord-015021-pol2qm74	1155	7	interleukin-8	interleukin-8	NNP
cord-015021-pol2qm74	1155	8	(	(	-LRB-
cord-015021-pol2qm74	1155	9	IL-8	IL-8	NNP
cord-015021-pol2qm74	1155	10	)	)	-RRB-
cord-015021-pol2qm74	1155	11	.	.	.
cord-015021-pol2qm74	1156	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	1156	2	,	,	,
cord-015021-pol2qm74	1156	3	a	a	DT
cord-015021-pol2qm74	1156	4	related	relate	VBN
cord-015021-pol2qm74	1156	5	supergene	supergene	JJ
cord-015021-pol2qm74	1156	6	family	family	NN
cord-015021-pol2qm74	1156	7	has	have	VBZ
cord-015021-pol2qm74	1156	8	been	be	VBN
cord-015021-pol2qm74	1156	9	identified	identify	VBN
cord-015021-pol2qm74	1156	10	which	which	WDT
cord-015021-pol2qm74	1156	11	possesses	possess	VBZ
cord-015021-pol2qm74	1156	12	activity	activity	NN
cord-015021-pol2qm74	1156	13	for	for	IN
cord-015021-pol2qm74	1156	14	recruiting	recruit	VBG
cord-015021-pol2qm74	1156	15	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	1156	16	cells	cell	NNS
cord-015021-pol2qm74	1156	17	.	.	.
cord-015021-pol2qm74	1157	1	Examples	example	NNS
cord-015021-pol2qm74	1157	2	of	of	IN
cord-015021-pol2qm74	1157	3	this	this	DT
cord-015021-pol2qm74	1157	4	group	group	NN
cord-015021-pol2qm74	1157	5	of	of	IN
cord-015021-pol2qm74	1157	6	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1157	7	chemukines	chemukine	NNS
cord-015021-pol2qm74	1157	8	are	be	VBP
cord-015021-pol2qm74	1157	9	monocyte	monocyte	NNP
cord-015021-pol2qm74	1157	10	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	1157	11	protein	protein	NN
cord-015021-pol2qm74	1157	12	-	-	:
cord-015021-pol2qm74	1157	13	i	i	NNP
cord-015021-pol2qm74	1157	14	(	(	-LRB-
cord-015021-pol2qm74	1157	15	MCP	MCP	NNP
cord-015021-pol2qm74	1157	16	-	-	HYPH
cord-015021-pol2qm74	1157	17	I	I	NNP
cord-015021-pol2qm74	1157	18	)	)	-RRB-
cord-015021-pol2qm74	1157	19	and	and	CC
cord-015021-pol2qm74	1157	20	macrophage	macrophage	VB
cord-015021-pol2qm74	1157	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1157	22	protein	protein	NN
cord-015021-pol2qm74	1157	23	-	-	:
cord-015021-pol2qm74	1157	24	i	i	PRP
cord-015021-pol2qm74	1157	25	alpha	alpha	NN
cord-015021-pol2qm74	1157	26	(	(	-LRB-
cord-015021-pol2qm74	1157	27	MIP	MIP	NNP
cord-015021-pol2qm74	1157	28	-	-	HYPH
cord-015021-pol2qm74	1157	29	I	I	NNP
cord-015021-pol2qm74	1157	30	)	)	-RRB-
cord-015021-pol2qm74	1157	31	.	.	.
cord-015021-pol2qm74	1158	1	In	in	IN
cord-015021-pol2qm74	1158	2	initial	initial	NN
cord-015021-pol2qm74	1158	3	in	in	IN
cord-015021-pol2qm74	1158	4	viva	viva	FW
cord-015021-pol2qm74	1158	5	studies	study	NNS
cord-015021-pol2qm74	1158	6	we	-PRON-	PRP
cord-015021-pol2qm74	1158	7	examined	examine	VBD
cord-015021-pol2qm74	1158	8	whether	whether	IN
cord-015021-pol2qm74	1158	9	MIP	MIP	NNP
cord-015021-pol2qm74	1158	10	-	-	HYPH
cord-015021-pol2qm74	1158	11	I	-PRON-	PRP
cord-015021-pol2qm74	1158	12	was	be	VBD
cord-015021-pol2qm74	1158	13	expressed	express	VBN
cord-015021-pol2qm74	1158	14	systemically	systemically	RB
cord-015021-pol2qm74	1158	15	or	or	CC
cord-015021-pol2qm74	1158	16	in	in	IN
cord-015021-pol2qm74	1158	17	a	a	DT
cord-015021-pol2qm74	1158	18	compartmentalized	compartmentalized	JJ
cord-015021-pol2qm74	1158	19	fashion	fashion	NN
cord-015021-pol2qm74	1158	20	post	post	NN
cord-015021-pol2qm74	1158	21	LPS	LPS	NNP
cord-015021-pol2qm74	1158	22	challenge	challenge	NN
cord-015021-pol2qm74	1158	23	.	.	.
cord-015021-pol2qm74	1159	1	Assessment	assessment	NN
cord-015021-pol2qm74	1159	2	of	of	IN
cord-015021-pol2qm74	1159	3	plasma	plasma	NN
cord-015021-pol2qm74	1159	4	cytokine	cytokine	NN
cord-015021-pol2qm74	1159	5	levels	level	NNS
cord-015021-pol2qm74	1159	6	revealed	reveal	VBD
cord-015021-pol2qm74	1159	7	maximal	maximal	JJ
cord-015021-pol2qm74	1159	8	TNF	TNF	NNP
cord-015021-pol2qm74	1159	9	levels	level	NNS
cord-015021-pol2qm74	1159	10	occurred	occur	VBD
cord-015021-pol2qm74	1159	11	I	-PRON-	PRP
cord-015021-pol2qm74	1159	12	hour	hour	VBP
cord-015021-pol2qm74	1159	13	post	post	NN
cord-015021-pol2qm74	1159	14	LPS	LPS	NNP
cord-015021-pol2qm74	1159	15	administration	administration	NN
cord-015021-pol2qm74	1159	16	,	,	,
cord-015021-pol2qm74	1159	17	returning	return	VBG
cord-015021-pol2qm74	1159	18	to	to	IN
cord-015021-pol2qm74	1159	19	baseline	baseline	NN
cord-015021-pol2qm74	1159	20	by	by	IN
cord-015021-pol2qm74	1159	21	4	4	CD
cord-015021-pol2qm74	1159	22	hours	hour	NNS
cord-015021-pol2qm74	1159	23	,	,	,
cord-015021-pol2qm74	1159	24	while	while	IN
cord-015021-pol2qm74	1159	25	MIP	MIP	NNP
cord-015021-pol2qm74	1159	26	-	-	HYPH
cord-015021-pol2qm74	1159	27	I	-PRON-	PRP
cord-015021-pol2qm74	1159	28	levels	level	NNS
cord-015021-pol2qm74	1159	29	were	be	VBD
cord-015021-pol2qm74	1159	30	maximal	maximal	JJ
cord-015021-pol2qm74	1159	31	at	at	IN
cord-015021-pol2qm74	1159	32	2	2	CD
cord-015021-pol2qm74	1159	33	hours	hour	NNS
cord-015021-pol2qm74	1159	34	(	(	-LRB-
cord-015021-pol2qm74	1159	35	2,5	2,5	CD
cord-015021-pol2qm74	1159	36	ng	ng	NN
cord-015021-pol2qm74	1159	37	/	/	SYM
cord-015021-pol2qm74	1159	38	ml	ml	NNP
cord-015021-pol2qm74	1159	39	)	)	-RRB-
cord-015021-pol2qm74	1159	40	,	,	,
cord-015021-pol2qm74	1159	41	with	with	IN
cord-015021-pol2qm74	1159	42	a	a	DT
cord-015021-pol2qm74	1159	43	second	second	JJ
cord-015021-pol2qm74	1159	44	peak	peak	NN
cord-015021-pol2qm74	1159	45	at	at	IN
cord-015021-pol2qm74	1159	46	24	24	CD
cord-015021-pol2qm74	1159	47	hours	hour	NNS
cord-015021-pol2qm74	1159	48	after	after	IN
cord-015021-pol2qm74	1159	49	LPS	LPS	NNP
cord-015021-pol2qm74	1159	50	challenge	challenge	NN
cord-015021-pol2qm74	1159	51	.	.	.
cord-015021-pol2qm74	1160	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	1160	2	,	,	,
cord-015021-pol2qm74	1160	3	aqueous	aqueous	JJ
cord-015021-pol2qm74	1160	4	extracts	extract	NNS
cord-015021-pol2qm74	1160	5	of	of	IN
cord-015021-pol2qm74	1160	6	liver	liver	NN
cord-015021-pol2qm74	1160	7	homogenates	homogenate	NNS
cord-015021-pol2qm74	1160	8	from	from	IN
cord-015021-pol2qm74	1160	9	LPS	LPS	NNP
cord-015021-pol2qm74	1160	10	treated	treat	VBN
cord-015021-pol2qm74	1160	11	animals	animal	NNS
cord-015021-pol2qm74	1160	12	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	1160	13	no	no	DT
cord-015021-pol2qm74	1160	14	MIP	MIP	NNP
cord-015021-pol2qm74	1160	15	-	-	HYPH
cord-015021-pol2qm74	1160	16	I	-PRON-	PRP
cord-015021-pol2qm74	1160	17	levels	level	NNS
cord-015021-pol2qm74	1160	18	,	,	,
cord-015021-pol2qm74	1160	19	while	while	IN
cord-015021-pol2qm74	1160	20	aqueous	aqueous	JJ
cord-015021-pol2qm74	1160	21	extracts	extract	NNS
cord-015021-pol2qm74	1160	22	of	of	IN
cord-015021-pol2qm74	1160	23	lung	lung	NN
cord-015021-pol2qm74	1160	24	revealed	reveal	VBD
cord-015021-pol2qm74	1160	25	a	a	DT
cord-015021-pol2qm74	1160	26	4-fold	4-fold	CD
cord-015021-pol2qm74	1160	27	increase	increase	NN
cord-015021-pol2qm74	1160	28	in	in	IN
cord-015021-pol2qm74	1160	29	MIP	MIP	NNP
cord-015021-pol2qm74	1160	30	-	-	HYPH
cord-015021-pol2qm74	1160	31	I	-PRON-	PRP
cord-015021-pol2qm74	1160	32	levels	level	NNS
cord-015021-pol2qm74	1160	33	over	over	IN
cord-015021-pol2qm74	1160	34	control	control	NN
cord-015021-pol2qm74	1160	35	lungs	lung	NNS
cord-015021-pol2qm74	1160	36	.	.	.
cord-015021-pol2qm74	1161	1	Immunohistochemical	immunohistochemical	JJ
cord-015021-pol2qm74	1161	2	analysis	analysis	NN
cord-015021-pol2qm74	1161	3	of	of	IN
cord-015021-pol2qm74	1161	4	the	the	DT
cord-015021-pol2qm74	1161	5	lungs	lung	NNS
cord-015021-pol2qm74	1161	6	from	from	IN
cord-015021-pol2qm74	1161	7	24	24	CD
cord-015021-pol2qm74	1161	8	hour	hour	NN
cord-015021-pol2qm74	1161	9	LPS	lp	NNS
cord-015021-pol2qm74	1161	10	treated	treat	VBN
cord-015021-pol2qm74	1161	11	animals	animal	NNS
cord-015021-pol2qm74	1161	12	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	1161	13	the	the	DT
cord-015021-pol2qm74	1161	14	alveolar	alveolar	JJ
cord-015021-pol2qm74	1161	15	macrophage	macrophage	NN
cord-015021-pol2qm74	1161	16	was	be	VBD
cord-015021-pol2qm74	1161	17	a	a	DT
cord-015021-pol2qm74	1161	18	rich	rich	JJ
cord-015021-pol2qm74	1161	19	source	source	NN
cord-015021-pol2qm74	1161	20	of	of	IN
cord-015021-pol2qm74	1161	21	MIP	MIP	NNP
cord-015021-pol2qm74	1161	22	-	-	HYPH
cord-015021-pol2qm74	1161	23	I	I	NNP
cord-015021-pol2qm74	1161	24	protein	protein	NN
cord-015021-pol2qm74	1161	25	.	.	.
cord-015021-pol2qm74	1162	1	Cell	cell	NN
cord-015021-pol2qm74	1162	2	-	-	HYPH
cord-015021-pol2qm74	1162	3	associated	associate	VBN
cord-015021-pol2qm74	1162	4	MIP	mip	NN
cord-015021-pol2qm74	1163	1	-I	-I	NNP
cord-015021-pol2qm74	1163	2	was	be	VBD
cord-015021-pol2qm74	1163	3	also	also	RB
cord-015021-pol2qm74	1163	4	expressed	express	VBN
cord-015021-pol2qm74	1163	5	by	by	IN
cord-015021-pol2qm74	1163	6	blood	blood	NN
cord-015021-pol2qm74	1163	7	monocytes	monocyte	NNS
cord-015021-pol2qm74	1163	8	adherent	adherent	JJ
cord-015021-pol2qm74	1163	9	to	to	IN
cord-015021-pol2qm74	1163	10	the	the	DT
cord-015021-pol2qm74	1163	11	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	1163	12	vascular	vascular	JJ
cord-015021-pol2qm74	1163	13	endotheliun	endotheliun	NN
cord-015021-pol2qm74	1163	14	,	,	,
cord-015021-pol2qm74	1163	15	however	however	RB
cord-015021-pol2qm74	1163	16	the	the	DT
cord-015021-pol2qm74	1163	17	expression	expression	NN
cord-015021-pol2qm74	1163	18	of	of	IN
cord-015021-pol2qm74	1163	19	monocyte	monocyte	NNP
cord-015021-pol2qm74	1163	20	-	-	HYPH
cord-015021-pol2qm74	1163	21	MIP	MIP	NNP
cord-015021-pol2qm74	1164	1	-i	-i	NNP
cord-015021-pol2qm74	1164	2	was	be	VBD
cord-015021-pol2qm74	1164	3	observed	observe	VBN
cord-015021-pol2qm74	1164	4	by	by	IN
cord-015021-pol2qm74	1164	5	2	2	CD
cord-015021-pol2qm74	1164	6	hours	hour	NNS
cord-015021-pol2qm74	1164	7	post	post	NN
cord-015021-pol2qm74	1164	8	LPS	LPS	NNP
cord-015021-pol2qm74	1164	9	administration	administration	NN
cord-015021-pol2qm74	1164	10	.	.	.
cord-015021-pol2qm74	1165	1	Immunohistochemical	immunohistochemical	JJ
cord-015021-pol2qm74	1165	2	analysis	analysis	NN
cord-015021-pol2qm74	1165	3	also	also	RB
cord-015021-pol2qm74	1165	4	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	1165	5	that	that	IN
cord-015021-pol2qm74	1165	6	MIP	MIP	NNP
cord-015021-pol2qm74	1165	7	-	-	HYPH
cord-015021-pol2qm74	1165	8	I	I	NNP
cord-015021-pol2qm74	1165	9	antigen	antigen	NN
cord-015021-pol2qm74	1165	10	is	be	VBZ
cord-015021-pol2qm74	1165	11	associated	associate	VBN
cord-015021-pol2qm74	1165	12	with	with	IN
cord-015021-pol2qm74	1165	13	the	the	DT
cord-015021-pol2qm74	1165	14	extracellular	extracellular	JJ
cord-015021-pol2qm74	1165	15	matrix	matrix	NN
cord-015021-pol2qm74	1165	16	on	on	IN
cord-015021-pol2qm74	1165	17	the	the	DT
cord-015021-pol2qm74	1165	18	interstitial	interstitial	JJ
cord-015021-pol2qm74	1165	19	side	side	NN
cord-015021-pol2qm74	1165	20	of	of	IN
cord-015021-pol2qm74	1165	21	the	the	DT
cord-015021-pol2qm74	1165	22	endothelium	endothelium	NN
cord-015021-pol2qm74	1165	23	.	.	.
cord-015021-pol2qm74	1166	1	This	this	DT
cord-015021-pol2qm74	1166	2	suggests	suggest	VBZ
cord-015021-pol2qm74	1166	3	that	that	IN
cord-015021-pol2qm74	1166	4	the	the	DT
cord-015021-pol2qm74	1166	5	extracellular	extracellular	JJ
cord-015021-pol2qm74	1166	6	matrix	matrix	NN
cord-015021-pol2qm74	1166	7	,	,	,
cord-015021-pol2qm74	1166	8	which	which	WDT
cord-015021-pol2qm74	1166	9	is	be	VBZ
cord-015021-pol2qm74	1166	10	produced	produce	VBN
cord-015021-pol2qm74	1166	11	during	during	IN
cord-015021-pol2qm74	1166	12	inflammation	inflammation	NN
cord-015021-pol2qm74	1166	13	,	,	,
cord-015021-pol2qm74	1166	14	can	can	MD
cord-015021-pol2qm74	1166	15	bind	bind	VB
cord-015021-pol2qm74	1166	16	MIP	MIP	NNP
cord-015021-pol2qm74	1166	17	-	-	HYPH
cord-015021-pol2qm74	1166	18	I	I	NNP
cord-015021-pol2qm74	1166	19	and	and	CC
cord-015021-pol2qm74	1166	20	this	this	DT
cord-015021-pol2qm74	1166	21	may	may	MD
cord-015021-pol2qm74	1166	22	serve	serve	VB
cord-015021-pol2qm74	1166	23	as	as	IN
cord-015021-pol2qm74	1166	24	a	a	DT
cord-015021-pol2qm74	1166	25	depot	depot	NN
cord-015021-pol2qm74	1166	26	for	for	IN
cord-015021-pol2qm74	1166	27	the	the	DT
cord-015021-pol2qm74	1166	28	prolonged	prolonged	JJ
cord-015021-pol2qm74	1166	29	presence	presence	NN
cord-015021-pol2qm74	1166	30	of	of	IN
cord-015021-pol2qm74	1166	31	NIP-1	NIP-1	NNP
cord-015021-pol2qm74	1166	32	.	.	.
cord-015021-pol2qm74	1167	1	In	in	IN
cord-015021-pol2qm74	1167	2	additional	additional	JJ
cord-015021-pol2qm74	1167	3	studies	study	NNS
cord-015021-pol2qm74	1167	4	we	-PRON-	PRP
cord-015021-pol2qm74	1167	5	have	have	VBP
cord-015021-pol2qm74	1167	6	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	1167	7	that	that	IN
cord-015021-pol2qm74	1167	8	the	the	DT
cord-015021-pol2qm74	1167	9	intratracheal	intratracheal	JJ
cord-015021-pol2qm74	1167	10	instillation	instillation	NN
cord-015021-pol2qm74	1167	11	of	of	IN
cord-015021-pol2qm74	1167	12	rMuI	rmui	DT
cord-015021-pol2qm74	1167	13	[	[	-LRB-
cord-015021-pol2qm74	1167	14	IP	IP	NNP
cord-015021-pol2qm74	1167	15	-	-	HYPH
cord-015021-pol2qm74	1167	16	l(lOOng	l(lOOng	NNP
cord-015021-pol2qm74	1167	17	)	)	-RRB-
cord-015021-pol2qm74	1167	18	 	 	_SP
cord-015021-pol2qm74	1167	19	Activation	Activation	NNP
cord-015021-pol2qm74	1167	20	of	of	IN
cord-015021-pol2qm74	1167	21	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	1167	22	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1167	23	by	by	IN
cord-015021-pol2qm74	1167	24	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1167	25	stimuli	stimulus	NNS
cord-015021-pol2qm74	1167	26	may	may	MD
cord-015021-pol2qm74	1167	27	contribute	contribute	VB
cord-015021-pol2qm74	1167	28	to	to	IN
cord-015021-pol2qm74	1167	29	the	the	DT
cord-015021-pol2qm74	1167	30	development	development	NN
cord-015021-pol2qm74	1167	31	of	of	IN
cord-015021-pol2qm74	1167	32	multiple	multiple	JJ
cord-015021-pol2qm74	1167	33	organ	organ	NN
cord-015021-pol2qm74	1167	34	failure	failure	NN
cord-015021-pol2qm74	1167	35	in	in	IN
cord-015021-pol2qm74	1167	36	septic	septic	JJ
cord-015021-pol2qm74	1167	37	patients	patient	NNS
cord-015021-pol2qm74	1167	38	.	.	.
cord-015021-pol2qm74	1168	1	Thereby	thereby	RB
cord-015021-pol2qm74	1168	2	PMNL	PMNL	NNP
cord-015021-pol2qm74	1168	3	are	be	VBP
cord-015021-pol2qm74	1168	4	proposed	propose	VBN
cord-015021-pol2qm74	1168	5	to	to	TO
cord-015021-pol2qm74	1168	6	avidly	avidly	RB
cord-015021-pol2qm74	1168	7	adhere	adhere	VB
cord-015021-pol2qm74	1168	8	to	to	IN
cord-015021-pol2qm74	1168	9	vascular	vascular	JJ
cord-015021-pol2qm74	1168	10	endothelium	endothelium	NN
cord-015021-pol2qm74	1168	11	causing	cause	VBG
cord-015021-pol2qm74	1168	12	damage	damage	NN
cord-015021-pol2qm74	1168	13	by	by	IN
cord-015021-pol2qm74	1168	14	the	the	DT
cord-015021-pol2qm74	1168	15	subsequent	subsequent	JJ
cord-015021-pol2qm74	1168	16	release	release	NN
cord-015021-pol2qm74	1168	17	of	of	IN
cord-015021-pol2qm74	1168	18	toxic	toxic	JJ
cord-015021-pol2qm74	1168	19	agents	agent	NNS
cord-015021-pol2qm74	1168	20	.	.	.
cord-015021-pol2qm74	1169	1	As	as	IN
cord-015021-pol2qm74	1169	2	cellular	cellular	JJ
cord-015021-pol2qm74	1169	3	adhesion	adhesion	NN
cord-015021-pol2qm74	1169	4	is	be	VBZ
cord-015021-pol2qm74	1169	5	primarily	primarily	RB
cord-015021-pol2qm74	1169	6	mediated	mediate	VBN
cord-015021-pol2qm74	1169	7	by	by	IN
cord-015021-pol2qm74	1169	8	62-integrins	62-integrins	CD
cord-015021-pol2qm74	1169	9	and	and	CC
cord-015021-pol2qm74	1169	10	Lselectins	Lselectins	NNP
cord-015021-pol2qm74	1169	11	,	,	,
cord-015021-pol2qm74	1169	12	the	the	DT
cord-015021-pol2qm74	1169	13	present	present	JJ
cord-015021-pol2qm74	1169	14	study	study	NN
cord-015021-pol2qm74	1169	15	compares	compare	VBZ
cord-015021-pol2qm74	1169	16	the	the	DT
cord-015021-pol2qm74	1169	17	expression	expression	NN
cord-015021-pol2qm74	1169	18	of	of	IN
cord-015021-pol2qm74	1169	19	these	these	DT
cord-015021-pol2qm74	1169	20	adhesionmolecules	adhesionmolecule	NNS
cord-015021-pol2qm74	1169	21	on	on	IN
cord-015021-pol2qm74	1169	22	PMNL	PMNL	NNP
cord-015021-pol2qm74	1169	23	in	in	IN
cord-015021-pol2qm74	1169	24	septic	septic	JJ
cord-015021-pol2qm74	1169	25	patients	patient	NNS
cord-015021-pol2qm74	1169	26	and	and	CC
cord-015021-pol2qm74	1169	27	healthy	healthy	JJ
cord-015021-pol2qm74	1169	28	volunteers	volunteer	NNS
cord-015021-pol2qm74	1169	29	.	.	.
cord-015021-pol2qm74	1170	1	Methods	method	NNS
cord-015021-pol2qm74	1170	2	:	:	:
cord-015021-pol2qm74	1170	3	Expression	expression	NN
cord-015021-pol2qm74	1170	4	of	of	IN
cord-015021-pol2qm74	1170	5	62-integrins	62-integrins	CD
cord-015021-pol2qm74	1170	6	and	and	CC
cord-015021-pol2qm74	1170	7	L	l	NN
cord-015021-pol2qm74	1170	8	-	-	HYPH
cord-015021-pol2qm74	1170	9	selectins	selectin	NNS
cord-015021-pol2qm74	1170	10	on	on	IN
cord-015021-pol2qm74	1170	11	PMNL	PMNL	NNP
cord-015021-pol2qm74	1170	12	was	be	VBD
cord-015021-pol2qm74	1170	13	measured	measure	VBN
cord-015021-pol2qm74	1170	14	in	in	IN
cord-015021-pol2qm74	1170	15	whole	whole	JJ
cord-015021-pol2qm74	1170	16	blood	blood	NN
cord-015021-pol2qm74	1170	17	by	by	IN
cord-015021-pol2qm74	1170	18	flow	flow	NN
cord-015021-pol2qm74	1170	19	cytometry	cytometry	NN
cord-015021-pol2qm74	1170	20	using	use	VBG
cord-015021-pol2qm74	1170	21	the	the	DT
cord-015021-pol2qm74	1170	22	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1170	23	antibodies	antibody	NNS
cord-015021-pol2qm74	1170	24	IB4	IB4	NNP
cord-015021-pol2qm74	1170	25	and	and	CC
cord-015021-pol2qm74	1170	26	Dreg	Dreg	NNP
cord-015021-pol2qm74	1170	27	200	200	CD
cord-015021-pol2qm74	1170	28	,	,	,
cord-015021-pol2qm74	1170	29	Baseline	baseline	JJ
cord-015021-pol2qm74	1170	30	values	value	NNS
cord-015021-pol2qm74	1170	31	were	be	VBD
cord-015021-pol2qm74	1170	32	determined	determine	VBN
cord-015021-pol2qm74	1170	33	immediatley	immediatley	RB
cord-015021-pol2qm74	1170	34	after	after	IN
cord-015021-pol2qm74	1170	35	drawing	draw	VBG
cord-015021-pol2qm74	1170	36	blood	blood	NN
cord-015021-pol2qm74	1170	37	.	.	.
cord-015021-pol2qm74	1171	1	In	in	IN
cord-015021-pol2qm74	1171	2	addition	addition	NN
cord-015021-pol2qm74	1171	3	cells	cell	NNS
cord-015021-pol2qm74	1171	4	were	be	VBD
cord-015021-pol2qm74	1171	5	incubated	incubate	VBN
cord-015021-pol2qm74	1171	6	45	45	CD
cord-015021-pol2qm74	1171	7	min	min	NN
cord-015021-pol2qm74	1171	8	at	at	IN
cord-015021-pol2qm74	1171	9	37	37	CD
cord-015021-pol2qm74	1171	10	°	°	NN
cord-015021-pol2qm74	1171	11	C	c	NN
cord-015021-pol2qm74	1171	12	to	to	TO
cord-015021-pol2qm74	1171	13	allow	allow	VB
cord-015021-pol2qm74	1171	14	for	for	IN
cord-015021-pol2qm74	1171	15	spontaneous	spontaneous	JJ
cord-015021-pol2qm74	1171	16	regulation	regulation	NN
cord-015021-pol2qm74	1171	17	of	of	IN
cord-015021-pol2qm74	1171	18	adhesion	adhesion	NN
cord-015021-pol2qm74	1171	19	molecules	molecule	NNS
cord-015021-pol2qm74	1171	20	.	.	.
cord-015021-pol2qm74	1172	1	55	55	CD
cord-015021-pol2qm74	1172	2	blood	blood	NN
cord-015021-pol2qm74	1172	3	specimens	specimen	NNS
cord-015021-pol2qm74	1172	4	from	from	IN
cord-015021-pol2qm74	1172	5	8	8	CD
cord-015021-pol2qm74	1172	6	septic	septic	JJ
cord-015021-pol2qm74	1172	7	patients	patient	NNS
cord-015021-pol2qm74	1172	8	were	be	VBD
cord-015021-pol2qm74	1172	9	obtained	obtain	VBN
cord-015021-pol2qm74	1172	10	during	during	IN
cord-015021-pol2qm74	1172	11	the	the	DT
cord-015021-pol2qm74	1172	12	course	course	NN
cord-015021-pol2qm74	1172	13	of	of	IN
cord-015021-pol2qm74	1172	14	their	-PRON-	PRP$
cord-015021-pol2qm74	1172	15	illness	illness	NN
cord-015021-pol2qm74	1172	16	.	.	.
cord-015021-pol2qm74	1173	1	Control	control	NN
cord-015021-pol2qm74	1173	2	values	value	NNS
cord-015021-pol2qm74	1173	3	were	be	VBD
cord-015021-pol2qm74	1173	4	determined	determine	VBN
cord-015021-pol2qm74	1173	5	in	in	IN
cord-015021-pol2qm74	1173	6	12	12	CD
cord-015021-pol2qm74	1173	7	healthy	healthy	JJ
cord-015021-pol2qm74	1173	8	volunteers	volunteer	NNS
cord-015021-pol2qm74	1173	9	.	.	.
cord-015021-pol2qm74	1174	1	Results	result	NNS
cord-015021-pol2qm74	1174	2	:	:	:
cord-015021-pol2qm74	1175	1	Baseline	baseline	JJ
cord-015021-pol2qm74	1175	2	expression	expression	NN
cord-015021-pol2qm74	1175	3	of	of	IN
cord-015021-pol2qm74	1175	4	62-integrins	62-integrins	CD
cord-015021-pol2qm74	1175	5	and	and	CC
cord-015021-pol2qm74	1175	6	L	l	NN
cord-015021-pol2qm74	1175	7	-	-	HYPH
cord-015021-pol2qm74	1175	8	selectins	selectins	NNP
cord-015021-pol2qm74	1175	9	was	be	VBD
cord-015021-pol2qm74	1175	10	not	not	RB
cord-015021-pol2qm74	1175	11	signifcantly	signifcantly	RB
cord-015021-pol2qm74	1175	12	different	different	JJ
cord-015021-pol2qm74	1175	13	in	in	IN
cord-015021-pol2qm74	1175	14	septic	septic	NN
cord-015021-pol2qm74	1175	15	and	and	CC
cord-015021-pol2qm74	1175	16	in	in	IN
cord-015021-pol2qm74	1175	17	healthy	healthy	JJ
cord-015021-pol2qm74	1175	18	subjects	subject	NNS
cord-015021-pol2qm74	1175	19	.	.	.
cord-015021-pol2qm74	1176	1	In	in	IN
cord-015021-pol2qm74	1176	2	contrast	contrast	NN
cord-015021-pol2qm74	1176	3	,	,	,
cord-015021-pol2qm74	1176	4	there	there	EX
cord-015021-pol2qm74	1176	5	was	be	VBD
cord-015021-pol2qm74	1176	6	a	a	DT
cord-015021-pol2qm74	1176	7	significant	significant	JJ
cord-015021-pol2qm74	1176	8	upregulation	upregulation	NN
cord-015021-pol2qm74	1176	9	of	of	IN
cord-015021-pol2qm74	1176	10	g2-integrins	g2-integrin	NNS
cord-015021-pol2qm74	1176	11	and	and	CC
cord-015021-pol2qm74	1176	12	shedding	shedding	NN
cord-015021-pol2qm74	1176	13	of	of	IN
cord-015021-pol2qm74	1176	14	L	l	NN
cord-015021-pol2qm74	1176	15	-	-	HYPH
cord-015021-pol2qm74	1176	16	selectins	selectin	NNS
cord-015021-pol2qm74	1176	17	of	of	IN
cord-015021-pol2qm74	1176	18	PMNL	PMNL	NNP
cord-015021-pol2qm74	1176	19	in	in	IN
cord-015021-pol2qm74	1176	20	septic	septic	JJ
cord-015021-pol2qm74	1176	21	patients	patient	NNS
cord-015021-pol2qm74	1176	22	(	(	-LRB-
cord-015021-pol2qm74	1176	23	SP	SP	NNP
cord-015021-pol2qm74	1176	24	)	)	-RRB-
cord-015021-pol2qm74	1176	25	compared	compare	VBN
cord-015021-pol2qm74	1176	26	to	to	IN
cord-015021-pol2qm74	1176	27	healthy	healthy	JJ
cord-015021-pol2qm74	1176	28	volunteers	volunteer	NNS
cord-015021-pol2qm74	1176	29	(	(	-LRB-
cord-015021-pol2qm74	1176	30	HV	HV	NNP
cord-015021-pol2qm74	1176	31	)	)	-RRB-
cord-015021-pol2qm74	1176	32	.	.	.
cord-015021-pol2qm74	1177	1	The	the	DT
cord-015021-pol2qm74	1177	2	local	local	JJ
cord-015021-pol2qm74	1177	3	or	or	CC
cord-015021-pol2qm74	1177	4	systemic	systemic	JJ
cord-015021-pol2qm74	1177	5	production	production	NN
cord-015021-pol2qm74	1177	6	of	of	IN
cord-015021-pol2qm74	1177	7	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1177	8	cytokines	cytokine	NNS
cord-015021-pol2qm74	1177	9	,	,	,
cord-015021-pol2qm74	1177	10	such	such	JJ
cord-015021-pol2qm74	1177	11	as	as	IN
cord-015021-pol2qm74	1177	12	tumor	tumor	NN
cord-015021-pol2qm74	1177	13	necrosis	necrosis	NN
cord-015021-pol2qm74	1177	14	factor	factor	NN
cord-015021-pol2qm74	1177	15	alpha	alpha	NN
cord-015021-pol2qm74	1177	16	(	(	-LRB-
cord-015021-pol2qm74	1177	17	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	1177	18	)	)	-RRB-
cord-015021-pol2qm74	1177	19	,	,	,
cord-015021-pol2qm74	1177	20	can	can	MD
cord-015021-pol2qm74	1177	21	serve	serve	VB
cord-015021-pol2qm74	1177	22	to	to	TO
cord-015021-pol2qm74	1177	23	modulate	modulate	VB
cord-015021-pol2qm74	1177	24	multiple	multiple	JJ
cord-015021-pol2qm74	1177	25	aspects	aspect	NNS
cord-015021-pol2qm74	1177	26	of	of	IN
cord-015021-pol2qm74	1177	27	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1177	28	function	function	NN
cord-015021-pol2qm74	1177	29	.	.	.
cord-015021-pol2qm74	1178	1	The	the	DT
cord-015021-pol2qm74	1178	2	ability	ability	NN
cord-015021-pol2qm74	1178	3	of	of	IN
cord-015021-pol2qm74	1178	4	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1178	5	to	to	TO
cord-015021-pol2qm74	1178	6	leave	leave	VB
cord-015021-pol2qm74	1178	7	the	the	DT
cord-015021-pol2qm74	1178	8	circulation	circulation	NN
cord-015021-pol2qm74	1178	9	and	and	CC
cord-015021-pol2qm74	1178	10	migrate	migrate	VB
cord-015021-pol2qm74	1178	11	to	to	IN
cord-015021-pol2qm74	1178	12	areas	area	NNS
cord-015021-pol2qm74	1178	13	of	of	IN
cord-015021-pol2qm74	1178	14	infection	infection	NN
cord-015021-pol2qm74	1178	15	is	be	VBZ
cord-015021-pol2qm74	1178	16	one	one	CD
cord-015021-pol2qm74	1178	17	essential	essential	JJ
cord-015021-pol2qm74	1178	18	component	component	NN
cord-015021-pol2qm74	1178	19	of	of	IN
cord-015021-pol2qm74	1178	20	host	host	NN
cord-015021-pol2qm74	1178	21	defense	defense	NN
cord-015021-pol2qm74	1178	22	.	.	.
cord-015021-pol2qm74	1179	1	L	L	NNP
cord-015021-pol2qm74	1179	2	-	-	HYPH
cord-015021-pol2qm74	1179	3	selectin	selectin	NNP
cord-015021-pol2qm74	1179	4	,	,	,
cord-015021-pol2qm74	1179	5	a	a	DT
cord-015021-pol2qm74	1179	6	leucocyte	leucocyte	RB
cord-015021-pol2qm74	1179	7	-	-	HYPH
cord-015021-pol2qm74	1179	8	associated	associate	VBN
cord-015021-pol2qm74	1179	9	adhesion	adhesion	NN
cord-015021-pol2qm74	1179	10	molecule	molecule	NN
cord-015021-pol2qm74	1179	11	,	,	,
cord-015021-pol2qm74	1179	12	is	be	VBZ
cord-015021-pol2qm74	1179	13	responsible	responsible	JJ
cord-015021-pol2qm74	1179	14	for	for	IN
cord-015021-pol2qm74	1179	15	the	the	DT
cord-015021-pol2qm74	1179	16	initial	initial	JJ
cord-015021-pol2qm74	1179	17	reversible	reversible	JJ
cord-015021-pol2qm74	1179	18	contact	contact	NN
cord-015021-pol2qm74	1179	19	between	between	IN
cord-015021-pol2qm74	1179	20	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1179	21	and	and	CC
cord-015021-pol2qm74	1179	22	endothelium	endothelium	NN
cord-015021-pol2qm74	1179	23	and	and	CC
cord-015021-pol2qm74	1179	24	the	the	DT
cord-015021-pol2qm74	1179	25	subsequent	subsequent	JJ
cord-015021-pol2qm74	1179	26	roiling	roil	VBG
cord-015021-pol2qm74	1179	27	action	action	NN
cord-015021-pol2qm74	1179	28	of	of	IN
cord-015021-pol2qm74	1179	29	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1179	30	along	along	IN
cord-015021-pol2qm74	1179	31	the	the	DT
cord-015021-pol2qm74	1179	32	vessel	vessel	NN
cord-015021-pol2qm74	1179	33	wall	wall	NN
cord-015021-pol2qm74	1179	34	.	.	.
cord-015021-pol2qm74	1180	1	In	in	IN
cord-015021-pol2qm74	1180	2	contrast	contrast	NN
cord-015021-pol2qm74	1180	3	to	to	IN
cord-015021-pol2qm74	1180	4	other	other	JJ
cord-015021-pol2qm74	1180	5	adhesion	adhesion	NN
cord-015021-pol2qm74	1180	6	molecules	molecule	NNS
cord-015021-pol2qm74	1180	7	,	,	,
cord-015021-pol2qm74	1180	8	L	L	NNP
cord-015021-pol2qm74	1180	9	-	-	HYPH
cord-015021-pol2qm74	1180	10	selectin	selectin	NNP
cord-015021-pol2qm74	1180	11	expression	expression	NN
cord-015021-pol2qm74	1180	12	is	be	VBZ
cord-015021-pol2qm74	1180	13	rapidly	rapidly	RB
cord-015021-pol2qm74	1180	14	down	down	RB
cord-015021-pol2qm74	1180	15	-	-	HYPH
cord-015021-pol2qm74	1180	16	regulated	regulate	VBN
cord-015021-pol2qm74	1180	17	after	after	IN
cord-015021-pol2qm74	1180	18	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1180	19	activation	activation	NN
cord-015021-pol2qm74	1180	20	.	.	.
cord-015021-pol2qm74	1181	1	The	the	DT
cord-015021-pol2qm74	1181	2	loss	loss	NN
cord-015021-pol2qm74	1181	3	of	of	IN
cord-015021-pol2qm74	1181	4	L	L	NNP
cord-015021-pol2qm74	1181	5	-	-	HYPH
cord-015021-pol2qm74	1181	6	seleclin	seleclin	NNP
cord-015021-pol2qm74	1181	7	may	may	MD
cord-015021-pol2qm74	1181	8	thus	thus	RB
cord-015021-pol2qm74	1181	9	be	be	VB
cord-015021-pol2qm74	1181	10	a	a	DT
cord-015021-pol2qm74	1181	11	critical	critical	JJ
cord-015021-pol2qm74	1181	12	determinant	determinant	NN
cord-015021-pol2qm74	1181	13	of	of	IN
cord-015021-pol2qm74	1181	14	how	how	WRB
cord-015021-pol2qm74	1181	15	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1181	16	become	become	VBP
cord-015021-pol2qm74	1181	17	unbound	unbound	JJ
cord-015021-pol2qm74	1181	18	from	from	IN
cord-015021-pol2qm74	1181	19	their	-PRON-	PRP$
cord-015021-pol2qm74	1181	20	endothelial	endothelial	JJ
cord-015021-pol2qm74	1181	21	attachments	attachment	NNS
cord-015021-pol2qm74	1181	22	and	and	CC
cord-015021-pol2qm74	1181	23	enabled	enable	VBD
cord-015021-pol2qm74	1181	24	to	to	TO
cord-015021-pol2qm74	1181	25	proceed	proceed	VB
cord-015021-pol2qm74	1181	26	towards	towards	IN
cord-015021-pol2qm74	1181	27	an	an	DT
cord-015021-pol2qm74	1181	28	underlying	underlie	VBG
cord-015021-pol2qm74	1181	29	extravascular	extravascular	JJ
cord-015021-pol2qm74	1181	30	area	area	NN
cord-015021-pol2qm74	1181	31	of	of	IN
cord-015021-pol2qm74	1181	32	infection	infection	NN
cord-015021-pol2qm74	1181	33	.	.	.
cord-015021-pol2qm74	1182	1	We	-PRON-	PRP
cord-015021-pol2qm74	1182	2	hypothesize	hypothesize	VBP
cord-015021-pol2qm74	1182	3	that	that	IN
cord-015021-pol2qm74	1182	4	the	the	DT
cord-015021-pol2qm74	1182	5	shedding	shedding	NN
cord-015021-pol2qm74	1182	6	of	of	IN
cord-015021-pol2qm74	1182	7	L	L	NNP
cord-015021-pol2qm74	1182	8	-	-	HYPH
cord-015021-pol2qm74	1182	9	selectin	selectin	NNP
cord-015021-pol2qm74	1182	10	is	be	VBZ
cord-015021-pol2qm74	1182	11	a	a	DT
cord-015021-pol2qm74	1182	12	strictly	strictly	RB
cord-015021-pol2qm74	1182	13	controlled	control	VBN
cord-015021-pol2qm74	1182	14	process	process	NN
cord-015021-pol2qm74	1182	15	,	,	,
cord-015021-pol2qm74	1182	16	occurring	occur	VBG
cord-015021-pol2qm74	1182	17	primarily	primarily	RB
cord-015021-pol2qm74	1182	18	at	at	IN
cord-015021-pol2qm74	1182	19	localized	localize	VBN
cord-015021-pol2qm74	1182	20	sites	site	NNS
cord-015021-pol2qm74	1182	21	of	of	IN
cord-015021-pol2qm74	1182	22	inflammation	inflammation	NN
cord-015021-pol2qm74	1182	23	,	,	,
cord-015021-pol2qm74	1182	24	which	which	WDT
cord-015021-pol2qm74	1182	25	may	may	MD
cord-015021-pol2qm74	1182	26	be	be	VB
cord-015021-pol2qm74	1182	27	modulated	modulate	VBN
cord-015021-pol2qm74	1182	28	by	by	IN
cord-015021-pol2qm74	1182	29	TNF~	tnf~	CD
cord-015021-pol2qm74	1182	30	,	,	,
cord-015021-pol2qm74	1182	31	A	a	DT
cord-015021-pol2qm74	1182	32	flow	flow	NN
cord-015021-pol2qm74	1182	33	cytometric	cytometric	NN
cord-015021-pol2qm74	1182	34	method	method	NN
cord-015021-pol2qm74	1182	35	of	of	IN
cord-015021-pol2qm74	1182	36	staining	stain	VBG
cord-015021-pol2qm74	1182	37	neutrophHs	neutrophh	NNS
cord-015021-pol2qm74	1182	38	by	by	IN
cord-015021-pol2qm74	1182	39	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1182	40	antibodies	antibody	NNS
cord-015021-pol2qm74	1182	41	in	in	IN
cord-015021-pol2qm74	1182	42	whole	whole	JJ
cord-015021-pol2qm74	1182	43	blood	blood	NN
cord-015021-pol2qm74	1182	44	is	be	VBZ
cord-015021-pol2qm74	1182	45	described	describe	VBN
cord-015021-pol2qm74	1182	46	whereby	whereby	WRB
cord-015021-pol2qm74	1182	47	the	the	DT
cord-015021-pol2qm74	1182	48	kinetics	kinetic	NNS
cord-015021-pol2qm74	1182	49	of	of	IN
cord-015021-pol2qm74	1182	50	L	L	NNP
cord-015021-pol2qm74	1182	51	-	-	HYPH
cord-015021-pol2qm74	1182	52	selectin	selectin	NNP
cord-015021-pol2qm74	1182	53	shedding	shedding	NN
cord-015021-pol2qm74	1182	54	may	may	MD
cord-015021-pol2qm74	1182	55	be	be	VB
cord-015021-pol2qm74	1182	56	followed	follow	VBN
cord-015021-pol2qm74	1182	57	in	in	IN
cord-015021-pol2qm74	1182	58	real	real	JJ
cord-015021-pol2qm74	1182	59	time	time	NN
cord-015021-pol2qm74	1182	60	.	.	.
cord-015021-pol2qm74	1183	1	The	the	DT
cord-015021-pol2qm74	1183	2	dose	dose	JJ
cord-015021-pol2qm74	1183	3	response	response	NN
cord-015021-pol2qm74	1183	4	and	and	CC
cord-015021-pol2qm74	1183	5	time	time	NN
cord-015021-pol2qm74	1183	6	course	course	NN
cord-015021-pol2qm74	1183	7	of	of	IN
cord-015021-pol2qm74	1183	8	in	in	IN
cord-015021-pol2qm74	1183	9	-	-	HYPH
cord-015021-pol2qm74	1183	10	vitro	vitro	FW
cord-015021-pol2qm74	1183	11	L	l	NN
cord-015021-pol2qm74	1183	12	-	-	HYPH
cord-015021-pol2qm74	1183	13	selectin	selectin	NNP
cord-015021-pol2qm74	1183	14	shedding	shed	VBG
cord-015021-pol2qm74	1183	15	by	by	IN
cord-015021-pol2qm74	1183	16	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1183	17	from	from	IN
cord-015021-pol2qm74	1183	18	normal	normal	JJ
cord-015021-pol2qm74	1183	19	human	human	JJ
cord-015021-pol2qm74	1183	20	subjects	subject	NNS
cord-015021-pol2qm74	1183	21	was	be	VBD
cord-015021-pol2qm74	1183	22	assayed	assay	VBN
cord-015021-pol2qm74	1183	23	after	after	IN
cord-015021-pol2qm74	1183	24	exposure	exposure	NN
cord-015021-pol2qm74	1183	25	to	to	IN
cord-015021-pol2qm74	1183	26	N	N	NNP
cord-015021-pol2qm74	1183	27	-	-	HYPH
cord-015021-pol2qm74	1183	28	formyl	formyl	NNP
cord-015021-pol2qm74	1183	29	-	-	HYPH
cord-015021-pol2qm74	1183	30	methionylleucyl	methionylleucyl	NN
cord-015021-pol2qm74	1183	31	-	-	HYPH
cord-015021-pol2qm74	1183	32	phenylalanine	phenylalanine	NN
cord-015021-pol2qm74	1183	33	(	(	-LRB-
cord-015021-pol2qm74	1183	34	FMLP	FMLP	NNP
cord-015021-pol2qm74	1183	35	)	)	-RRB-
cord-015021-pol2qm74	1183	36	and	and	CC
cord-015021-pol2qm74	1183	37	TNFc~.	TNFc~.	NNP
cord-015021-pol2qm74	1183	38	either	either	CC
cord-015021-pol2qm74	1183	39	singly	singly	RB
cord-015021-pol2qm74	1183	40	or	or	CC
cord-015021-pol2qm74	1183	41	in	in	IN
cord-015021-pol2qm74	1183	42	combination	combination	NN
cord-015021-pol2qm74	1184	1	,	,	,
cord-015021-pol2qm74	1184	2	Our	-PRON-	PRP$
cord-015021-pol2qm74	1184	3	results	result	NNS
cord-015021-pol2qm74	1184	4	show	show	VBP
cord-015021-pol2qm74	1184	5	that	that	IN
cord-015021-pol2qm74	1184	6	L	L	NNP
cord-015021-pol2qm74	1184	7	-	-	HYPH
cord-015021-pol2qm74	1184	8	selectin	selectin	NNP
cord-015021-pol2qm74	1184	9	shedding	shedding	NN
cord-015021-pol2qm74	1184	10	can	can	MD
cord-015021-pol2qm74	1184	11	be	be	VB
cord-015021-pol2qm74	1184	12	reliably	reliably	RB
cord-015021-pol2qm74	1184	13	followed	follow	VBN
cord-015021-pol2qm74	1184	14	over	over	IN
cord-015021-pol2qm74	1184	15	time	time	NN
cord-015021-pol2qm74	1184	16	.	.	.
cord-015021-pol2qm74	1185	1	A	a	DT
cord-015021-pol2qm74	1185	2	significant	significant	JJ
cord-015021-pol2qm74	1185	3	percentage	percentage	NN
cord-015021-pol2qm74	1185	4	of	of	IN
cord-015021-pol2qm74	1185	5	cells	cell	NNS
cord-015021-pol2qm74	1185	6	shed	shed	VBP
cord-015021-pol2qm74	1185	7	L	L	NNP
cord-015021-pol2qm74	1185	8	-	-	HYPH
cord-015021-pol2qm74	1185	9	selectin	selectin	NNP
cord-015021-pol2qm74	1185	10	after	after	IN
cord-015021-pol2qm74	1185	11	exposure	exposure	NN
cord-015021-pol2qm74	1185	12	to	to	IN
cord-015021-pol2qm74	1185	13	2000	2000	CD
cord-015021-pol2qm74	1185	14	pg	pg	NN
cord-015021-pol2qm74	1185	15	/	/	SYM
cord-015021-pol2qm74	1185	16	ml	ml	NNP
cord-015021-pol2qm74	1185	17	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	1185	18	or	or	CC
cord-015021-pol2qm74	1185	19	1000nM	1000nm	CD
cord-015021-pol2qm74	1185	20	FMLP	FMLP	NNP
cord-015021-pol2qm74	1185	21	(	(	-LRB-
cord-015021-pol2qm74	1186	1	but	but	CC
cord-015021-pol2qm74	1186	2	not	not	RB
cord-015021-pol2qm74	1186	3	at	at	IN
cord-015021-pol2qm74	1186	4	400pg/	400pg/	CD
cord-015021-pol2qm74	1187	1	ml	ml	NNP
cord-015021-pol2qm74	1188	1	TNFc~	tnfc~	CD
cord-015021-pol2qm74	1188	2	or	or	CC
cord-015021-pol2qm74	1188	3	200nM	200nM	VBN
cord-015021-pol2qm74	1188	4	FMLP	FMLP	NNP
cord-015021-pol2qm74	1188	5	)	)	-RRB-
cord-015021-pol2qm74	1188	6	.	.	.
cord-015021-pol2qm74	1189	1	Greater	great	JJR
cord-015021-pol2qm74	1189	2	numbers	number	NNS
cord-015021-pol2qm74	1189	3	of	of	IN
cord-015021-pol2qm74	1189	4	cells	cell	NNS
cord-015021-pol2qm74	1189	5	were	be	VBD
cord-015021-pol2qm74	1189	6	able	able	JJ
cord-015021-pol2qm74	1189	7	to	to	TO
cord-015021-pol2qm74	1189	8	shed	shed	VB
cord-015021-pol2qm74	1189	9	their	-PRON-	PRP$
cord-015021-pol2qm74	1189	10	L	l	NN
cord-015021-pol2qm74	1189	11	-	-	HYPH
cord-015021-pol2qm74	1189	12	selectin	selectin	NNP
cord-015021-pol2qm74	1189	13	when	when	WRB
cord-015021-pol2qm74	1189	14	FMLP	FMLP	NNP
cord-015021-pol2qm74	1189	15	and	and	CC
cord-015021-pol2qm74	1189	16	TNF	TNF	NNP
cord-015021-pol2qm74	1189	17	~	~	NFP
cord-015021-pol2qm74	1189	18	x	x	:
cord-015021-pol2qm74	1189	19	were	be	VBD
cord-015021-pol2qm74	1189	20	presented	present	VBN
cord-015021-pol2qm74	1189	21	in	in	IN
cord-015021-pol2qm74	1189	22	combination	combination	NN
cord-015021-pol2qm74	1189	23	rather	rather	RB
cord-015021-pol2qm74	1189	24	than	than	IN
cord-015021-pol2qm74	1189	25	alone	alone	JJ
cord-015021-pol2qm74	1189	26	.	.	.
cord-015021-pol2qm74	1190	1	High	high	JJ
cord-015021-pol2qm74	1190	2	levels	level	NNS
cord-015021-pol2qm74	1190	3	of	of	IN
cord-015021-pol2qm74	1190	4	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	1190	5	did	do	VBD
cord-015021-pol2qm74	1190	6	not	not	RB
cord-015021-pol2qm74	1190	7	appear	appear	VB
cord-015021-pol2qm74	1190	8	to	to	TO
cord-015021-pol2qm74	1190	9	alter	alter	VB
cord-015021-pol2qm74	1190	10	the	the	DT
cord-015021-pol2qm74	1190	11	threshold	threshold	NN
cord-015021-pol2qm74	1190	12	concentration	concentration	NN
cord-015021-pol2qm74	1190	13	of	of	IN
cord-015021-pol2qm74	1190	14	FMLP	FMLP	NNP
cord-015021-pol2qm74	1190	15	required	require	VBD
cord-015021-pol2qm74	1190	16	to	to	TO
cord-015021-pol2qm74	1190	17	induce	induce	VB
cord-015021-pol2qm74	1190	18	shedding	shed	VBG
cord-015021-pol2qm74	1190	19	,	,	,
cord-015021-pol2qm74	1190	20	We	-PRON-	PRP
cord-015021-pol2qm74	1190	21	conclude	conclude	VBP
cord-015021-pol2qm74	1190	22	that	that	IN
cord-015021-pol2qm74	1190	23	the	the	DT
cord-015021-pol2qm74	1190	24	extent	extent	NN
cord-015021-pol2qm74	1190	25	and	and	CC
cord-015021-pol2qm74	1190	26	rapidity	rapidity	NN
cord-015021-pol2qm74	1190	27	of	of	IN
cord-015021-pol2qm74	1190	28	L	L	NNP
cord-015021-pol2qm74	1190	29	-	-	HYPH
cord-015021-pol2qm74	1190	30	selectin	selectin	NNP
cord-015021-pol2qm74	1190	31	shedding	shedding	NN
cord-015021-pol2qm74	1190	32	may	may	MD
cord-015021-pol2qm74	1190	33	be	be	VB
cord-015021-pol2qm74	1190	34	modified	modify	VBN
cord-015021-pol2qm74	1190	35	by	by	IN
cord-015021-pol2qm74	1190	36	different	different	JJ
cord-015021-pol2qm74	1190	37	combinations	combination	NNS
cord-015021-pol2qm74	1190	38	of	of	IN
cord-015021-pol2qm74	1190	39	ligands	ligand	NNS
cord-015021-pol2qm74	1190	40	and	and	CC
cord-015021-pol2qm74	1190	41	that	that	IN
cord-015021-pol2qm74	1190	42	shedding	shedding	NN
cord-015021-pol2qm74	1190	43	,	,	,
cord-015021-pol2qm74	1190	44	by	by	IN
cord-015021-pol2qm74	1190	45	vidue	vidue	NNP
cord-015021-pol2qm74	1190	46	of	of	IN
cord-015021-pol2qm74	1190	47	the	the	DT
cord-015021-pol2qm74	1190	48	high	high	JJ
cord-015021-pol2qm74	1190	49	concentrations	concentration	NNS
cord-015021-pol2qm74	1190	50	of	of	IN
cord-015021-pol2qm74	1190	51	cytokines	cytokine	NNS
cord-015021-pol2qm74	1190	52	or	or	CC
cord-015021-pol2qm74	1190	53	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	1190	54	factors	factor	NNS
cord-015021-pol2qm74	1190	55	required	require	VBN
cord-015021-pol2qm74	1190	56	,	,	,
cord-015021-pol2qm74	1190	57	is	be	VBZ
cord-015021-pol2qm74	1190	58	a	a	DT
cord-015021-pol2qm74	1190	59	process	process	NN
cord-015021-pol2qm74	1190	60	localized	localize	VBN
cord-015021-pol2qm74	1190	61	to	to	IN
cord-015021-pol2qm74	1190	62	sites	site	NNS
cord-015021-pol2qm74	1190	63	of	of	IN
cord-015021-pol2qm74	1190	64	infection	infection	NN
cord-015021-pol2qm74	1190	65	or	or	CC
cord-015021-pol2qm74	1190	66	inflammation	inflammation	NN
cord-015021-pol2qm74	1190	67	.	.	.
cord-015021-pol2qm74	1191	1	We	-PRON-	PRP
cord-015021-pol2qm74	1191	2	prospectively	prospectively	RB
cord-015021-pol2qm74	1191	3	studied	study	VBD
cord-015021-pol2qm74	1191	4	23	23	CD
cord-015021-pol2qm74	1191	5	patients	patient	NNS
cord-015021-pol2qm74	1191	6	with	with	IN
cord-015021-pol2qm74	1191	7	severe	severe	JJ
cord-015021-pol2qm74	1191	8	sepsis	sepsis	NN
cord-015021-pol2qm74	1191	9	syndrome	syndrome	NN
cord-015021-pol2qm74	1191	10	;	;	:
cord-015021-pol2qm74	1191	11	Group	Group	NNP
cord-015021-pol2qm74	1191	12	A	A	NNP
cord-015021-pol2qm74	1191	13	:	:	:
cord-015021-pol2qm74	1191	14	Septic	septic	JJ
cord-015021-pol2qm74	1191	15	shock	shock	NN
cord-015021-pol2qm74	1191	16	with	with	IN
cord-015021-pol2qm74	1191	17	or	or	CC
cord-015021-pol2qm74	1191	18	without	without	IN
cord-015021-pol2qm74	1191	19	Adult	Adult	NNP
cord-015021-pol2qm74	1191	20	Respiratory	Respiratory	NNP
cord-015021-pol2qm74	1191	21	Distress	Distress	NNP
cord-015021-pol2qm74	1191	22	Syndrome	Syndrome	NNP
cord-015021-pol2qm74	1191	23	lARDS	lards	NN
cord-015021-pol2qm74	1191	24	)	)	-RRB-
cord-015021-pol2qm74	1192	1	(	(	-LRB-
cord-015021-pol2qm74	1192	2	n	n	NN
cord-015021-pol2qm74	1192	3	=	=	SYM
cord-015021-pol2qm74	1192	4	7	7	CD
cord-015021-pol2qm74	1192	5	,	,	,
cord-015021-pol2qm74	1192	6	bacteremia	bacteremia	NN
cord-015021-pol2qm74	1192	7	=	=	SYM
cord-015021-pol2qm74	1192	8	6	6	CD
cord-015021-pol2qm74	1192	9	)	)	-RRB-
cord-015021-pol2qm74	1192	10	;	;	:
cord-015021-pol2qm74	1192	11	Group	Group	NNP
cord-015021-pol2qm74	1192	12	B	B	NNP
cord-015021-pol2qm74	1192	13	:	:	:
cord-015021-pol2qm74	1193	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	1193	2	syndrome	syndrome	NN
cord-015021-pol2qm74	1193	3	without	without	IN
cord-015021-pol2qm74	1193	4	septic	septic	JJ
cord-015021-pol2qm74	1193	5	shock	shock	NN
cord-015021-pol2qm74	1193	6	(	(	-LRB-
cord-015021-pol2qm74	1193	7	n	n	NN
cord-015021-pol2qm74	1193	8	=	=	SYM
cord-015021-pol2qm74	1193	9	16	16	CD
cord-015021-pol2qm74	1193	10	,	,	,
cord-015021-pol2qm74	1193	11	bacteremia	bacteremia	NN
cord-015021-pol2qm74	1193	12	=	=	SYM
cord-015021-pol2qm74	1193	13	9	9	CD
cord-015021-pol2qm74	1193	14	)	)	-RRB-
cord-015021-pol2qm74	1193	15	.	.	.
cord-015021-pol2qm74	1194	1	Serial	serial	JJ
cord-015021-pol2qm74	1194	2	plasma	plasma	NN
cord-015021-pol2qm74	1194	3	samples	sample	NNS
cord-015021-pol2qm74	1194	4	obtained	obtain	VBN
cord-015021-pol2qm74	1194	5	on	on	IN
cord-015021-pol2qm74	1194	6	day	day	NN
cord-015021-pol2qm74	1194	7	0	0	CD
cord-015021-pol2qm74	1194	8	,	,	,
cord-015021-pol2qm74	1194	9	1	1	CD
cord-015021-pol2qm74	1194	10	,	,	,
cord-015021-pol2qm74	1194	11	3	3	CD
cord-015021-pol2qm74	1194	12	,	,	,
cord-015021-pol2qm74	1194	13	6	6	CD
cord-015021-pol2qm74	1194	14	,	,	,
cord-015021-pol2qm74	1194	15	10	10	CD
cord-015021-pol2qm74	1194	16	and	and	CC
cord-015021-pol2qm74	1194	17	14	14	CD
cord-015021-pol2qm74	1194	18	,	,	,
cord-015021-pol2qm74	1194	19	were	be	VBD
cord-015021-pol2qm74	1194	20	assayed	assay	VBN
cord-015021-pol2qm74	1194	21	using	use	VBG
cord-015021-pol2qm74	1194	22	ELISAs	elisa	NNS
cord-015021-pol2qm74	1194	23	method	method	NN
cord-015021-pol2qm74	1194	24	(	(	-LRB-
cord-015021-pol2qm74	1194	25	British	British	NNP
cord-015021-pol2qm74	1194	26	Biotechnology	Biotechnology	NNP
cord-015021-pol2qm74	1194	27	)	)	-RRB-
cord-015021-pol2qm74	1194	28	,	,	,
cord-015021-pol2qm74	1194	29	Normal	normal	JJ
cord-015021-pol2qm74	1194	30	control	control	NN
cord-015021-pol2qm74	1194	31	levels	level	NNS
cord-015021-pol2qm74	1194	32	of	of	IN
cord-015021-pol2qm74	1194	33	soluble	soluble	JJ
cord-015021-pol2qm74	1194	34	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1194	35	and	and	CC
cord-015021-pol2qm74	1194	36	E	E	NNP
cord-015021-pol2qm74	1194	37	-	-	NNP
cord-015021-pol2qm74	1194	38	Selectin	Selectin	NNP
cord-015021-pol2qm74	1194	39	,	,	,
cord-015021-pol2qm74	1194	40	obtained	obtain	VBN
cord-015021-pol2qm74	1194	41	from	from	IN
cord-015021-pol2qm74	1194	42	11	11	CD
cord-015021-pol2qm74	1194	43	healthy	healthy	JJ
cord-015021-pol2qm74	1194	44	volunteers	volunteer	NNS
cord-015021-pol2qm74	1194	45	,	,	,
cord-015021-pol2qm74	1194	46	were	be	VBD
cord-015021-pol2qm74	1194	47	respectively	respectively	RB
cord-015021-pol2qm74	1194	48	205	205	CD
cord-015021-pol2qm74	1194	49	±	±	CD
cord-015021-pol2qm74	1194	50	19.4	19.4	CD
cord-015021-pol2qm74	1194	51	ng	ng	NNP
cord-015021-pol2qm74	1194	52	/	/	SYM
cord-015021-pol2qm74	1194	53	ml	ml	NN
cord-015021-pol2qm74	1194	54	and	and	CC
cord-015021-pol2qm74	1194	55	45	45	CD
cord-015021-pol2qm74	1194	56	±	±	CD
cord-015021-pol2qm74	1194	57	5.7	5.7	CD
cord-015021-pol2qm74	1194	58	ng	ng	NN
cord-015021-pol2qm74	1194	59	/	/	SYM
cord-015021-pol2qm74	1194	60	ml	ml	NN
cord-015021-pol2qm74	1195	1	(	(	-LRB-
cord-015021-pol2qm74	1195	2	mean	mean	VB
cord-015021-pol2qm74	1195	3	_	_	NN
cord-015021-pol2qm74	1195	4	+	+	CC
cord-015021-pol2qm74	1195	5	SE	SE	NNP
cord-015021-pol2qm74	1195	6	)	)	-RRB-
cord-015021-pol2qm74	1195	7	,	,	,
cord-015021-pol2qm74	1195	8	Acute	acute	JJ
cord-015021-pol2qm74	1195	9	lung	lung	NN
cord-015021-pol2qm74	1195	10	injury	injury	NN
cord-015021-pol2qm74	1195	11	was	be	VBD
cord-015021-pol2qm74	1195	12	quantified	quantify	VBN
cord-015021-pol2qm74	1195	13	dally	dally	RB
cord-015021-pol2qm74	1195	14	on	on	IN
cord-015021-pol2qm74	1195	15	a	a	DT
cord-015021-pol2qm74	1195	16	tour	tour	NN
cord-015021-pol2qm74	1195	17	-	-	HYPH
cord-015021-pol2qm74	1195	18	point	point	NN
cord-015021-pol2qm74	1195	19	score	score	NN
cord-015021-pol2qm74	1195	20	system	system	NN
cord-015021-pol2qm74	1195	21	(	(	-LRB-
cord-015021-pol2qm74	1195	22	Murray	Murray	NNP
cord-015021-pol2qm74	1195	23	,	,	,
cord-015021-pol2qm74	1195	24	Am	Am	NNP
cord-015021-pol2qm74	1195	25	Rev	Rev	NNP
cord-015021-pol2qm74	1195	26	Respir	Respir	NNP
cord-015021-pol2qm74	1195	27	Dis,1989	dis,1989	CD
cord-015021-pol2qm74	1195	28	)	)	-RRB-
cord-015021-pol2qm74	1195	29	.	.	.
cord-015021-pol2qm74	1196	1	Compared	compare	VBN
cord-015021-pol2qm74	1196	2	to	to	TO
cord-015021-pol2qm74	1196	3	control	control	VB
cord-015021-pol2qm74	1196	4	mean	mean	JJ
cord-015021-pol2qm74	1196	5	values	value	NNS
cord-015021-pol2qm74	1196	6	,	,	,
cord-015021-pol2qm74	1196	7	initial	initial	JJ
cord-015021-pol2qm74	1196	8	levels	level	NNS
cord-015021-pol2qm74	1196	9	of	of	IN
cord-015021-pol2qm74	1196	10	groups	group	NNS
cord-015021-pol2qm74	1196	11	A	A	NNP
cord-015021-pol2qm74	1196	12	and	and	CC
cord-015021-pol2qm74	1196	13	B	B	NNP
cord-015021-pol2qm74	1196	14	were	be	VBD
cord-015021-pol2qm74	1196	15	significantly	significantly	RB
cord-015021-pol2qm74	1196	16	higher	high	JJR
cord-015021-pol2qm74	1196	17	for	for	IN
cord-015021-pol2qm74	1196	18	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1196	19	(	(	-LRB-
cord-015021-pol2qm74	1196	20	p	p	NN
cord-015021-pol2qm74	1196	21	<	<	XX
cord-015021-pol2qm74	1196	22	10	10	CD
cord-015021-pol2qm74	1196	23	-4	-4	CD
cord-015021-pol2qm74	1196	24	)	)	-RRB-
cord-015021-pol2qm74	1196	25	and	and	CC
cord-015021-pol2qm74	1196	26	E	E	NNP
cord-015021-pol2qm74	1196	27	-	-	NN
cord-015021-pol2qm74	1196	28	Selectin	Selectin	NNP
cord-015021-pol2qm74	1197	1	(	(	-LRB-
cord-015021-pol2qm74	1197	2	p	p	NN
cord-015021-pol2qm74	1197	3	<	<	XX
cord-015021-pol2qm74	1197	4	10	10	CD
cord-015021-pol2qm74	1197	5	-	-	SYM
cord-015021-pol2qm74	1197	6	3	3	CD
cord-015021-pol2qm74	1197	7	)	)	-RRB-
cord-015021-pol2qm74	1197	8	.	.	.
cord-015021-pol2qm74	1198	1	Comparisons	comparison	NNS
cord-015021-pol2qm74	1198	2	of	of	IN
cord-015021-pol2qm74	1198	3	group	group	NN
cord-015021-pol2qm74	1198	4	A	a	NN
cord-015021-pol2qm74	1199	1	and	and	CC
cord-015021-pol2qm74	1199	2	[	[	-LRB-
cord-015021-pol2qm74	1199	3	]	]	-RRB-
cord-015021-pol2qm74	1200	1	(	(	-LRB-
cord-015021-pol2qm74	1200	2	*	*	NFP
cord-015021-pol2qm74	1200	3	=	=	SYM
cord-015021-pol2qm74	1200	4	p<0.05	p<0.05	CD
cord-015021-pol2qm74	1201	1	;	;	:
cord-015021-pol2qm74	1202	1	*	*	NFP
cord-015021-pol2qm74	1202	2	*	*	NFP
cord-015021-pol2qm74	1202	3	=	=	NFP
cord-015021-pol2qm74	1203	1	p<0.00	p<0.00	JJ
cord-015021-pol2qm74	1204	1	t	t	NNP
cord-015021-pol2qm74	1204	2	)	)	-RRB-
cord-015021-pol2qm74	1205	1	Soluble	soluble	JJ
cord-015021-pol2qm74	1205	2	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1205	3	levels	level	NNS
cord-015021-pol2qm74	1205	4	of	of	IN
cord-015021-pol2qm74	1205	5	group	group	NN
cord-015021-pol2qm74	1205	6	A	a	NN
cord-015021-pol2qm74	1206	1	enhanced	enhance	VBN
cord-015021-pol2qm74	1206	2	significantly	significantly	RB
cord-015021-pol2qm74	1206	3	(	(	-LRB-
cord-015021-pol2qm74	1206	4	p<0.05	p<0.05	CD
cord-015021-pol2qm74	1206	5	)	)	-RRB-
cord-015021-pol2qm74	1207	1	during	during	IN
cord-015021-pol2qm74	1207	2	the	the	DT
cord-015021-pol2qm74	1207	3	first	first	JJ
cord-015021-pol2qm74	1207	4	24	24	CD
cord-015021-pol2qm74	1207	5	hours	hour	NNS
cord-015021-pol2qm74	1207	6	,	,	,
cord-015021-pol2qm74	1207	7	and	and	CC
cord-015021-pol2qm74	1207	8	a	a	DT
cord-015021-pol2qm74	1207	9	sustained	sustained	JJ
cord-015021-pol2qm74	1207	10	high	high	JJ
cord-015021-pol2qm74	1207	11	levels	level	NNS
cord-015021-pol2qm74	1207	12	was	be	VBD
cord-015021-pol2qm74	1207	13	of	of	IN
cord-015021-pol2qm74	1207	14	bad	bad	JJ
cord-015021-pol2qm74	1207	15	prognosis	prognosis	NN
cord-015021-pol2qm74	1207	16	(	(	-LRB-
cord-015021-pol2qm74	1207	17	25	25	CD
cord-015021-pol2qm74	1207	18	%	%	NN
cord-015021-pol2qm74	1207	19	of	of	IN
cord-015021-pol2qm74	1207	20	survivors	survivor	NNS
cord-015021-pol2qm74	1207	21	at	at	IN
cord-015021-pol2qm74	1207	22	day	day	NN
cord-015021-pol2qm74	1207	23	6	6	CD
cord-015021-pol2qm74	1207	24	)	)	-RRB-
cord-015021-pol2qm74	1207	25	.	.	.
cord-015021-pol2qm74	1208	1	The	the	DT
cord-015021-pol2qm74	1208	2	evolution	evolution	NN
cord-015021-pol2qm74	1208	3	of	of	IN
cord-015021-pol2qm74	1208	4	soluble	soluble	JJ
cord-015021-pol2qm74	1208	5	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1208	6	and	and	CC
cord-015021-pol2qm74	1208	7	E	E	NNP
cord-015021-pol2qm74	1208	8	-	-	HYPH
cord-015021-pol2qm74	1208	9	Selectin	Selectin	NNP
cord-015021-pol2qm74	1208	10	levels	level	NNS
cord-015021-pol2qm74	1208	11	were	be	VBD
cord-015021-pol2qm74	1208	12	significantly	significantly	RB
cord-015021-pol2qm74	1208	13	correlated	correlate	VBN
cord-015021-pol2qm74	1208	14	with	with	IN
cord-015021-pol2qm74	1208	15	Murray	Murray	NNP
cord-015021-pol2qm74	1208	16	's	's	POS
cord-015021-pol2qm74	1208	17	score	score	NN
cord-015021-pol2qm74	1208	18	(	(	-LRB-
cord-015021-pol2qm74	1208	19	Spearman	Spearman	NNP
cord-015021-pol2qm74	1208	20	test	test	NN
cord-015021-pol2qm74	1208	21	:	:	:
cord-015021-pol2qm74	1208	22	p	p	NN
cord-015021-pol2qm74	1208	23	<	<	XX
cord-015021-pol2qm74	1208	24	0.001	0.001	CD
cord-015021-pol2qm74	1208	25	)	)	-RRB-
cord-015021-pol2qm74	1208	26	.	.	.
cord-015021-pol2qm74	1209	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	1209	2	:	:	:
cord-015021-pol2qm74	1210	1	These	these	DT
cord-015021-pol2qm74	1210	2	results	result	NNS
cord-015021-pol2qm74	1210	3	suggest	suggest	VBP
cord-015021-pol2qm74	1210	4	that	that	IN
cord-015021-pol2qm74	1210	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	1210	6	adhesion	adhesion	NN
cord-015021-pol2qm74	1210	7	molecules	molecule	NNS
cord-015021-pol2qm74	1210	8	are	be	VBP
cord-015021-pol2qm74	1210	9	released	release	VBN
cord-015021-pol2qm74	1210	10	into	into	IN
cord-015021-pol2qm74	1210	11	the	the	DT
cord-015021-pol2qm74	1210	12	plasma	plasma	NN
cord-015021-pol2qm74	1210	13	of	of	IN
cord-015021-pol2qm74	1210	14	patients	patient	NNS
cord-015021-pol2qm74	1210	15	with	with	IN
cord-015021-pol2qm74	1210	16	severe	severe	JJ
cord-015021-pol2qm74	1210	17	sepsis	sepsis	NN
cord-015021-pol2qm74	1210	18	syndrome	syndrome	NN
cord-015021-pol2qm74	1210	19	.	.	.
cord-015021-pol2qm74	1211	1	Soluble	soluble	JJ
cord-015021-pol2qm74	1211	2	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1211	3	and	and	CC
cord-015021-pol2qm74	1211	4	E	E	NNP
cord-015021-pol2qm74	1211	5	-	-	:
cord-015021-pol2qm74	1211	6	Selectin	Selectin	NNP
cord-015021-pol2qm74	1211	7	are	be	VBP
cord-015021-pol2qm74	1211	8	correlated	correlate	VBN
cord-015021-pol2qm74	1211	9	with	with	IN
cord-015021-pol2qm74	1211	10	endothelial	endothelial	JJ
cord-015021-pol2qm74	1211	11	lung	lung	NN
cord-015021-pol2qm74	1211	12	damage	damage	NN
cord-015021-pol2qm74	1211	13	,	,	,
cord-015021-pol2qm74	1211	14	and	and	CC
cord-015021-pol2qm74	1211	15	lOAM-1	loam-1	NN
cord-015021-pol2qm74	1211	16	seems	seem	VBZ
cord-015021-pol2qm74	1211	17	to	to	TO
cord-015021-pol2qm74	1211	18	be	be	VB
cord-015021-pol2qm74	1211	19	a	a	DT
cord-015021-pol2qm74	1211	20	better	well	JJR
cord-015021-pol2qm74	1211	21	indicator	indicator	NN
cord-015021-pol2qm74	1211	22	of	of	IN
cord-015021-pol2qm74	1211	23	the	the	DT
cord-015021-pol2qm74	1211	24	severity	severity	NN
cord-015021-pol2qm74	1211	25	of	of	IN
cord-015021-pol2qm74	1211	26	endothelial	endothelial	JJ
cord-015021-pol2qm74	1211	27	injury	injury	NN
cord-015021-pol2qm74	1211	28	.	.	.
cord-015021-pol2qm74	1211	29	 	 	_SP
cord-015021-pol2qm74	1212	1	Introductory	introductory	JJ
cord-015021-pol2qm74	1212	2	remarks	remark	VBZ
cord-015021-pol2qm74	1212	3	to	to	IN
cord-015021-pol2qm74	1212	4	anti	anti	JJ
cord-015021-pol2qm74	1212	5	-	-	JJ
cord-015021-pol2qm74	1212	6	adhesion	adhesion	JJ
cord-015021-pol2qm74	1212	7	molecule	molecule	NN
cord-015021-pol2qm74	1212	8	strategies	strategy	NNS
cord-015021-pol2qm74	1212	9	as	as	IN
cord-015021-pol2qm74	1212	10	a	a	DT
cord-015021-pol2qm74	1212	11	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1212	12	modality	modality	NN
cord-015021-pol2qm74	1212	13	CH	CH	NNP
cord-015021-pol2qm74	1212	14	Wortel	Wortel	NNP
cord-015021-pol2qm74	1212	15	,	,	,
cord-015021-pol2qm74	1212	16	Repligen	Repligen	NNP
cord-015021-pol2qm74	1212	17	Corporation	Corporation	NNP
cord-015021-pol2qm74	1212	18	,	,	,
cord-015021-pol2qm74	1212	19	One	one	CD
cord-015021-pol2qm74	1212	20	Kendall	Kendall	NNP
cord-015021-pol2qm74	1212	21	Square	Square	NNP
cord-015021-pol2qm74	1212	22	,	,	,
cord-015021-pol2qm74	1212	23	Building	Building	NNP
cord-015021-pol2qm74	1212	24	700	700	CD
cord-015021-pol2qm74	1212	25	,	,	,
cord-015021-pol2qm74	1212	26	Cambridge	Cambridge	NNP
cord-015021-pol2qm74	1212	27	,	,	,
cord-015021-pol2qm74	1212	28	MA	MA	NNP
cord-015021-pol2qm74	1212	29	02139	02139	CD
cord-015021-pol2qm74	1212	30	,	,	,
cord-015021-pol2qm74	1212	31	USA	USA	NNP
cord-015021-pol2qm74	1212	32	.	.	.
cord-015021-pol2qm74	1213	1	The	the	DT
cord-015021-pol2qm74	1213	2	development	development	NN
cord-015021-pol2qm74	1213	3	of	of	IN
cord-015021-pol2qm74	1213	4	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	1213	5	therapy	therapy	NN
cord-015021-pol2qm74	1213	6	represented	represent	VBD
cord-015021-pol2qm74	1213	7	a	a	DT
cord-015021-pol2qm74	1213	8	major	major	JJ
cord-015021-pol2qm74	1213	9	breakthrough	breakthrough	NN
cord-015021-pol2qm74	1213	10	in	in	IN
cord-015021-pol2qm74	1213	11	the	the	DT
cord-015021-pol2qm74	1213	12	struggle	struggle	NN
cord-015021-pol2qm74	1213	13	against	against	IN
cord-015021-pol2qm74	1213	14	disease	disease	NN
cord-015021-pol2qm74	1213	15	.	.	.
cord-015021-pol2qm74	1214	1	It	-PRON-	PRP
cord-015021-pol2qm74	1214	2	strengthened	strengthen	VBD
cord-015021-pol2qm74	1214	3	the	the	DT
cord-015021-pol2qm74	1214	4	notion	notion	NN
cord-015021-pol2qm74	1214	5	that	that	IN
cord-015021-pol2qm74	1214	6	disease	disease	NN
cord-015021-pol2qm74	1214	7	could	could	MD
cord-015021-pol2qm74	1214	8	be	be	VB
cord-015021-pol2qm74	1214	9	overcome	overcome	VBN
cord-015021-pol2qm74	1214	10	by	by	IN
cord-015021-pol2qm74	1214	11	eliminating	eliminate	VBG
cord-015021-pol2qm74	1214	12	foreign	foreign	JJ
cord-015021-pol2qm74	1214	13	invaders	invader	NNS
cord-015021-pol2qm74	1214	14	threatening	threaten	VBG
cord-015021-pol2qm74	1214	15	the	the	DT
cord-015021-pol2qm74	1214	16	host	host	NN
cord-015021-pol2qm74	1214	17	.	.	.
cord-015021-pol2qm74	1215	1	This	this	DT
cord-015021-pol2qm74	1215	2	paradigm	paradigm	NN
cord-015021-pol2qm74	1215	3	has	have	VBZ
cord-015021-pol2qm74	1215	4	proven	prove	VBN
cord-015021-pol2qm74	1215	5	to	to	TO
cord-015021-pol2qm74	1215	6	be	be	VB
cord-015021-pol2qm74	1215	7	very	very	RB
cord-015021-pol2qm74	1215	8	successful	successful	JJ
cord-015021-pol2qm74	1215	9	,	,	,
cord-015021-pol2qm74	1215	10	the	the	DT
cord-015021-pol2qm74	1215	11	threat	threat	NN
cord-015021-pol2qm74	1215	12	of	of	IN
cord-015021-pol2qm74	1215	13	many	many	JJ
cord-015021-pol2qm74	1215	14	infectious	infectious	JJ
cord-015021-pol2qm74	1215	15	diseases	disease	NNS
cord-015021-pol2qm74	1215	16	has	have	VBZ
cord-015021-pol2qm74	1215	17	significantly	significantly	RB
cord-015021-pol2qm74	1215	18	changed	change	VBN
cord-015021-pol2qm74	1215	19	,	,	,
cord-015021-pol2qm74	1215	20	some	some	DT
cord-015021-pol2qm74	1215	21	have	have	VBP
cord-015021-pol2qm74	1215	22	even	even	RB
cord-015021-pol2qm74	1215	23	been	be	VBN
cord-015021-pol2qm74	1215	24	eradicated	eradicate	VBN
cord-015021-pol2qm74	1215	25	.	.	.
cord-015021-pol2qm74	1216	1	Nevertheless	nevertheless	RB
cord-015021-pol2qm74	1216	2	,	,	,
cord-015021-pol2qm74	1216	3	sepsis	sepsis	NN
cord-015021-pol2qm74	1216	4	has	have	VBZ
cord-015021-pol2qm74	1216	5	remained	remain	VBN
cord-015021-pol2qm74	1216	6	a	a	DT
cord-015021-pol2qm74	1216	7	severe	severe	JJ
cord-015021-pol2qm74	1216	8	condition	condition	NN
cord-015021-pol2qm74	1216	9	,	,	,
cord-015021-pol2qm74	1216	10	increasing	increase	VBG
cord-015021-pol2qm74	1216	11	in	in	IN
cord-015021-pol2qm74	1216	12	incidence	incidence	NN
cord-015021-pol2qm74	1216	13	while	while	IN
cord-015021-pol2qm74	1216	14	mortality	mortality	NN
cord-015021-pol2qm74	1216	15	remained	remain	VBD
cord-015021-pol2qm74	1216	16	very	very	RB
cord-015021-pol2qm74	1216	17	high	high	JJ
cord-015021-pol2qm74	1216	18	.	.	.
cord-015021-pol2qm74	1217	1	More	more	RBR
cord-015021-pol2qm74	1217	2	recently	recently	RB
cord-015021-pol2qm74	1217	3	,	,	,
cord-015021-pol2qm74	1217	4	it	-PRON-	PRP
cord-015021-pol2qm74	1217	5	has	have	VBZ
cord-015021-pol2qm74	1217	6	become	become	VBN
cord-015021-pol2qm74	1217	7	increasingly	increasingly	RB
cord-015021-pol2qm74	1217	8	clear	clear	JJ
cord-015021-pol2qm74	1217	9	that	that	IN
cord-015021-pol2qm74	1217	10	besides	besides	IN
cord-015021-pol2qm74	1217	11	the	the	DT
cord-015021-pol2qm74	1217	12	nature	nature	NN
cord-015021-pol2qm74	1217	13	and	and	CC
cord-015021-pol2qm74	1217	14	treatment	treatment	NN
cord-015021-pol2qm74	1217	15	of	of	IN
cord-015021-pol2qm74	1217	16	an	an	DT
cord-015021-pol2qm74	1217	17	exogenous	exogenous	JJ
cord-015021-pol2qm74	1217	18	agent	agent	NN
cord-015021-pol2qm74	1217	19	,	,	,
cord-015021-pol2qm74	1217	20	the	the	DT
cord-015021-pol2qm74	1217	21	reaction	reaction	NN
cord-015021-pol2qm74	1217	22	of	of	IN
cord-015021-pol2qm74	1217	23	the	the	DT
cord-015021-pol2qm74	1217	24	host	host	NN
cord-015021-pol2qm74	1217	25	defense	defense	NN
cord-015021-pol2qm74	1217	26	itself	-PRON-	PRP
cord-015021-pol2qm74	1217	27	plays	play	VBZ
cord-015021-pol2qm74	1217	28	a	a	DT
cord-015021-pol2qm74	1217	29	pivotal	pivotal	JJ
cord-015021-pol2qm74	1217	30	role	role	NN
cord-015021-pol2qm74	1217	31	in	in	IN
cord-015021-pol2qm74	1217	32	the	the	DT
cord-015021-pol2qm74	1217	33	outcome	outcome	NN
cord-015021-pol2qm74	1217	34	of	of	IN
cord-015021-pol2qm74	1217	35	the	the	DT
cord-015021-pol2qm74	1217	36	event	event	NN
cord-015021-pol2qm74	1217	37	.	.	.
cord-015021-pol2qm74	1218	1	Endogenous	endogenous	JJ
cord-015021-pol2qm74	1218	2	mediators	mediator	NNS
cord-015021-pol2qm74	1218	3	,	,	,
cord-015021-pol2qm74	1218	4	such	such	JJ
cord-015021-pol2qm74	1218	5	as	as	IN
cord-015021-pol2qm74	1218	6	TNF	TNF	NNP
cord-015021-pol2qm74	1218	7	,	,	,
cord-015021-pol2qm74	1218	8	IL	IL	NNP
cord-015021-pol2qm74	1218	9	-	-	HYPH
cord-015021-pol2qm74	1218	10	I	I	NNP
cord-015021-pol2qm74	1218	11	,	,	,
cord-015021-pol2qm74	1218	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	1218	13	and	and	CC
cord-015021-pol2qm74	1218	14	IL-8	IL-8	NNP
cord-015021-pol2qm74	1218	15	,	,	,
cord-015021-pol2qm74	1218	16	govem	govem	JJ
cord-015021-pol2qm74	1218	17	many	many	JJ
cord-015021-pol2qm74	1218	18	of	of	IN
cord-015021-pol2qm74	1218	19	the	the	DT
cord-015021-pol2qm74	1218	20	actions	action	NNS
cord-015021-pol2qm74	1218	21	of	of	IN
cord-015021-pol2qm74	1218	22	the	the	DT
cord-015021-pol2qm74	1218	23	host	host	NN
cord-015021-pol2qm74	1218	24	defense	defense	NN
cord-015021-pol2qm74	1218	25	system	system	NN
cord-015021-pol2qm74	1218	26	.	.	.
cord-015021-pol2qm74	1219	1	While	while	IN
cord-015021-pol2qm74	1219	2	the	the	DT
cord-015021-pol2qm74	1219	3	expression	expression	NN
cord-015021-pol2qm74	1219	4	of	of	IN
cord-015021-pol2qm74	1219	5	these	these	DT
cord-015021-pol2qm74	1219	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	1219	7	more	more	RBR
cord-015021-pol2qm74	1219	8	often	often	RB
cord-015021-pol2qm74	1219	9	than	than	IN
cord-015021-pol2qm74	1219	10	not	not	RB
cord-015021-pol2qm74	1219	11	benefit	benefit	VB
cord-015021-pol2qm74	1219	12	the	the	DT
cord-015021-pol2qm74	1219	13	host	host	NN
cord-015021-pol2qm74	1219	14	,	,	,
cord-015021-pol2qm74	1219	15	(	(	-LRB-
cord-015021-pol2qm74	1219	16	over)-expression	over)-expression	NN
cord-015021-pol2qm74	1219	17	can	can	MD
cord-015021-pol2qm74	1219	18	cause	cause	VB
cord-015021-pol2qm74	1219	19	severe	severe	JJ
cord-015021-pol2qm74	1219	20	damage	damage	NN
cord-015021-pol2qm74	1219	21	.	.	.
cord-015021-pol2qm74	1220	1	Based	base	VBN
cord-015021-pol2qm74	1220	2	on	on	IN
cord-015021-pol2qm74	1220	3	this	this	DT
cord-015021-pol2qm74	1220	4	hypothesis	hypothesis	NN
cord-015021-pol2qm74	1220	5	,	,	,
cord-015021-pol2qm74	1220	6	anticytokine	anticytokine	JJ
cord-015021-pol2qm74	1220	7	strategies	strategy	NNS
cord-015021-pol2qm74	1220	8	,	,	,
cord-015021-pol2qm74	1220	9	such	such	JJ
cord-015021-pol2qm74	1220	10	as	as	IN
cord-015021-pol2qm74	1220	11	those	those	DT
cord-015021-pol2qm74	1220	12	targeted	target	VBN
cord-015021-pol2qm74	1220	13	against	against	IN
cord-015021-pol2qm74	1220	14	TNF	TNF	NNP
cord-015021-pol2qm74	1220	15	or	or	CC
cord-015021-pol2qm74	1220	16	IL-1	IL-1	NNP
cord-015021-pol2qm74	1220	17	,	,	,
cord-015021-pol2qm74	1220	18	have	have	VBP
cord-015021-pol2qm74	1220	19	been	be	VBN
cord-015021-pol2qm74	1220	20	evaluated	evaluate	VBN
cord-015021-pol2qm74	1220	21	for	for	IN
cord-015021-pol2qm74	1220	22	the	the	DT
cord-015021-pol2qm74	1220	23	treatment	treatment	NN
cord-015021-pol2qm74	1220	24	of	of	IN
cord-015021-pol2qm74	1220	25	sepsis	sepsis	NN
cord-015021-pol2qm74	1220	26	.	.	.
cord-015021-pol2qm74	1221	1	Results	result	NNS
cord-015021-pol2qm74	1221	2	of	of	IN
cord-015021-pol2qm74	1221	3	these	these	DT
cord-015021-pol2qm74	1221	4	early	early	JJ
cord-015021-pol2qm74	1221	5	studies	study	NNS
cord-015021-pol2qm74	1221	6	have	have	VBP
cord-015021-pol2qm74	1221	7	not	not	RB
cord-015021-pol2qm74	1221	8	yet	yet	RB
cord-015021-pol2qm74	1221	9	indicated	indicate	VBN
cord-015021-pol2qm74	1221	10	success	success	NN
cord-015021-pol2qm74	1221	11	in	in	IN
cord-015021-pol2qm74	1221	12	improving	improve	VBG
cord-015021-pol2qm74	1221	13	the	the	DT
cord-015021-pol2qm74	1221	14	outcome	outcome	NN
cord-015021-pol2qm74	1221	15	of	of	IN
cord-015021-pol2qm74	1221	16	the	the	DT
cord-015021-pol2qm74	1221	17	disease	disease	NN
cord-015021-pol2qm74	1221	18	.	.	.
cord-015021-pol2qm74	1222	1	It	-PRON-	PRP
cord-015021-pol2qm74	1222	2	has	have	VBZ
cord-015021-pol2qm74	1222	3	been	be	VBN
cord-015021-pol2qm74	1222	4	difficult	difficult	JJ
cord-015021-pol2qm74	1222	5	to	to	TO
cord-015021-pol2qm74	1222	6	define	define	VB
cord-015021-pol2qm74	1222	7	a	a	DT
cord-015021-pol2qm74	1222	8	patient	patient	JJ
cord-015021-pol2qm74	1222	9	population	population	NN
cord-015021-pol2qm74	1222	10	where	where	WRB
cord-015021-pol2qm74	1222	11	a	a	DT
cord-015021-pol2qm74	1222	12	benefit	benefit	NN
cord-015021-pol2qm74	1222	13	could	could	MD
cord-015021-pol2qm74	1222	14	be	be	VB
cord-015021-pol2qm74	1222	15	reproducibly	reproducibly	RB
cord-015021-pol2qm74	1222	16	shown	show	VBN
cord-015021-pol2qm74	1222	17	.	.	.
cord-015021-pol2qm74	1223	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	1223	2	,	,	,
cord-015021-pol2qm74	1223	3	it	-PRON-	PRP
cord-015021-pol2qm74	1223	4	has	have	VBZ
cord-015021-pol2qm74	1223	5	been	be	VBN
cord-015021-pol2qm74	1223	6	documented	document	VBN
cord-015021-pol2qm74	1223	7	that	that	IN
cord-015021-pol2qm74	1223	8	synergy	synergy	NN
cord-015021-pol2qm74	1223	9	between	between	IN
cord-015021-pol2qm74	1223	10	cytokines	cytokine	NNS
cord-015021-pol2qm74	1223	11	occurs	occur	VBZ
cord-015021-pol2qm74	1223	12	,	,	,
cord-015021-pol2qm74	1223	13	but	but	CC
cord-015021-pol2qm74	1223	14	detailed	detailed	JJ
cord-015021-pol2qm74	1223	15	knowledge	knowledge	NN
cord-015021-pol2qm74	1223	16	of	of	IN
cord-015021-pol2qm74	1223	17	the	the	DT
cord-015021-pol2qm74	1223	18	cytokine	cytokine	NN
cord-015021-pol2qm74	1223	19	network	network	NN
cord-015021-pol2qm74	1223	20	is	be	VBZ
cord-015021-pol2qm74	1223	21	not	not	RB
cord-015021-pol2qm74	1223	22	yet	yet	RB
cord-015021-pol2qm74	1223	23	available	available	JJ
cord-015021-pol2qm74	1223	24	.	.	.
cord-015021-pol2qm74	1224	1	It	-PRON-	PRP
cord-015021-pol2qm74	1224	2	is	be	VBZ
cord-015021-pol2qm74	1224	3	conceivable	conceivable	JJ
cord-015021-pol2qm74	1224	4	,	,	,
cord-015021-pol2qm74	1224	5	that	that	DT
cord-015021-pol2qm74	1224	6	neutralization	neutralization	NN
cord-015021-pol2qm74	1224	7	of	of	IN
cord-015021-pol2qm74	1224	8	one	one	CD
cord-015021-pol2qm74	1224	9	cytokine	cytokine	NN
cord-015021-pol2qm74	1224	10	prompts	prompt	VBZ
cord-015021-pol2qm74	1224	11	the	the	DT
cord-015021-pol2qm74	1224	12	induction	induction	NN
cord-015021-pol2qm74	1224	13	of	of	IN
cord-015021-pol2qm74	1224	14	another	another	DT
cord-015021-pol2qm74	1224	15	which	which	WDT
cord-015021-pol2qm74	1224	16	will	will	MD
cord-015021-pol2qm74	1224	17	evoke	evoke	VB
cord-015021-pol2qm74	1224	18	the	the	DT
cord-015021-pol2qm74	1224	19	intended	intended	JJ
cord-015021-pol2qm74	1224	20	response	response	NN
cord-015021-pol2qm74	1224	21	in	in	IN
cord-015021-pol2qm74	1224	22	the	the	DT
cord-015021-pol2qm74	1224	23	host	host	NN
cord-015021-pol2qm74	1224	24	.	.	.
cord-015021-pol2qm74	1225	1	Recent	recent	JJ
cord-015021-pol2qm74	1225	2	data	datum	NNS
cord-015021-pol2qm74	1225	3	obtained	obtain	VBN
cord-015021-pol2qm74	1225	4	in	in	IN
cord-015021-pol2qm74	1225	5	human	human	JJ
cord-015021-pol2qm74	1225	6	endotoxemic	endotoxemic	JJ
cord-015021-pol2qm74	1225	7	volunteer	volunteer	NN
cord-015021-pol2qm74	1225	8	models	model	NNS
cord-015021-pol2qm74	1225	9	seem	seem	VBP
cord-015021-pol2qm74	1225	10	to	to	TO
cord-015021-pol2qm74	1225	11	confirm	confirm	VB
cord-015021-pol2qm74	1225	12	this	this	DT
cord-015021-pol2qm74	1225	13	.	.	.
cord-015021-pol2qm74	1226	1	If	if	IN
cord-015021-pol2qm74	1226	2	this	this	DT
cord-015021-pol2qm74	1226	3	turns	turn	VBZ
cord-015021-pol2qm74	1226	4	out	out	RP
cord-015021-pol2qm74	1226	5	to	to	TO
cord-015021-pol2qm74	1226	6	be	be	VB
cord-015021-pol2qm74	1226	7	the	the	DT
cord-015021-pol2qm74	1226	8	case	case	NN
cord-015021-pol2qm74	1226	9	,	,	,
cord-015021-pol2qm74	1226	10	neutralizing	neutralize	VBG
cord-015021-pol2qm74	1226	11	a	a	DT
cord-015021-pol2qm74	1226	12	single	single	JJ
cord-015021-pol2qm74	1226	13	cytokine	cytokine	NN
cord-015021-pol2qm74	1226	14	may	may	MD
cord-015021-pol2qm74	1226	15	not	not	RB
cord-015021-pol2qm74	1226	16	be	be	VB
cord-015021-pol2qm74	1226	17	a	a	DT
cord-015021-pol2qm74	1226	18	successful	successful	JJ
cord-015021-pol2qm74	1226	19	approach	approach	NN
cord-015021-pol2qm74	1226	20	.	.	.
cord-015021-pol2qm74	1227	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	1227	2	in	in	IN
cord-015021-pol2qm74	1227	3	tum	tum	NNP
cord-015021-pol2qm74	1227	4	,	,	,
cord-015021-pol2qm74	1227	5	induce	induce	VB
cord-015021-pol2qm74	1227	6	various	various	JJ
cord-015021-pol2qm74	1227	7	adhesion	adhesion	NN
cord-015021-pol2qm74	1227	8	molecules	molecule	NNS
cord-015021-pol2qm74	1227	9	,	,	,
cord-015021-pol2qm74	1227	10	such	such	JJ
cord-015021-pol2qm74	1227	11	as	as	IN
cord-015021-pol2qm74	1227	12	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1227	13	.	.	.
cord-015021-pol2qm74	1228	1	Such	such	JJ
cord-015021-pol2qm74	1228	2	molecules	molecule	NNS
cord-015021-pol2qm74	1228	3	regulate	regulate	VBP
cord-015021-pol2qm74	1228	4	for	for	IN
cord-015021-pol2qm74	1228	5	instance	instance	NN
cord-015021-pol2qm74	1228	6	the	the	DT
cord-015021-pol2qm74	1228	7	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1228	8	-	-	HYPH
cord-015021-pol2qm74	1228	9	endothelial	endothelial	JJ
cord-015021-pol2qm74	1228	10	cell	cell	NN
cord-015021-pol2qm74	1228	11	interactions	interaction	NNS
cord-015021-pol2qm74	1228	12	,	,	,
cord-015021-pol2qm74	1228	13	which	which	WDT
cord-015021-pol2qm74	1228	14	are	be	VBP
cord-015021-pol2qm74	1228	15	thought	think	VBN
cord-015021-pol2qm74	1228	16	to	to	TO
cord-015021-pol2qm74	1228	17	play	play	VB
cord-015021-pol2qm74	1228	18	an	an	DT
cord-015021-pol2qm74	1228	19	important	important	JJ
cord-015021-pol2qm74	1228	20	role	role	NN
cord-015021-pol2qm74	1228	21	in	in	IN
cord-015021-pol2qm74	1228	22	the	the	DT
cord-015021-pol2qm74	1228	23	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	1228	24	of	of	IN
cord-015021-pol2qm74	1228	25	systemic	systemic	JJ
cord-015021-pol2qm74	1228	26	organ	organ	NN
cord-015021-pol2qm74	1228	27	injury	injury	NN
cord-015021-pol2qm74	1228	28	.	.	.
cord-015021-pol2qm74	1229	1	The	the	DT
cord-015021-pol2qm74	1229	2	potential	potential	NN
cord-015021-pol2qm74	1229	3	for	for	IN
cord-015021-pol2qm74	1229	4	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1229	5	antibodies	antibody	NNS
cord-015021-pol2qm74	1229	6	to	to	TO
cord-015021-pol2qm74	1229	7	adhesion	adhesion	NN
cord-015021-pol2qm74	1229	8	proteins	protein	NNS
cord-015021-pol2qm74	1229	9	to	to	TO
cord-015021-pol2qm74	1229	10	reduce	reduce	VB
cord-015021-pol2qm74	1229	11	vascular	vascular	JJ
cord-015021-pol2qm74	1229	12	and	and	CC
cord-015021-pol2qm74	1229	13	tissue	tissue	NN
cord-015021-pol2qm74	1229	14	damage	damage	NN
cord-015021-pol2qm74	1229	15	has	have	VBZ
cord-015021-pol2qm74	1229	16	been	be	VBN
cord-015021-pol2qm74	1229	17	studied	study	VBN
cord-015021-pol2qm74	1229	18	in	in	IN
cord-015021-pol2qm74	1229	19	a	a	DT
cord-015021-pol2qm74	1229	20	large	large	JJ
cord-015021-pol2qm74	1229	21	number	number	NN
cord-015021-pol2qm74	1229	22	of	of	IN
cord-015021-pol2qm74	1229	23	experimental	experimental	JJ
cord-015021-pol2qm74	1229	24	models	model	NNS
cord-015021-pol2qm74	1229	25	.	.	.
cord-015021-pol2qm74	1230	1	Protective	protective	JJ
cord-015021-pol2qm74	1230	2	effects	effect	NNS
cord-015021-pol2qm74	1230	3	have	have	VBP
cord-015021-pol2qm74	1230	4	been	be	VBN
cord-015021-pol2qm74	1230	5	observed	observe	VBN
cord-015021-pol2qm74	1230	6	in	in	IN
cord-015021-pol2qm74	1230	7	a	a	DT
cord-015021-pol2qm74	1230	8	wide	wide	JJ
cord-015021-pol2qm74	1230	9	variety	variety	NN
cord-015021-pol2qm74	1230	10	of	of	IN
cord-015021-pol2qm74	1230	11	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1230	12	,	,	,
cord-015021-pol2qm74	1230	13	immune	immune	JJ
cord-015021-pol2qm74	1230	14	,	,	,
cord-015021-pol2qm74	1230	15	and	and	CC
cord-015021-pol2qm74	1230	16	ischemia	ischemia	NN
cord-015021-pol2qm74	1230	17	-	-	HYPH
cord-015021-pol2qm74	1230	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1230	19	injuries	injury	NNS
cord-015021-pol2qm74	1230	20	.	.	.
cord-015021-pol2qm74	1231	1	Thus	thus	RB
cord-015021-pol2qm74	1231	2	,	,	,
cord-015021-pol2qm74	1231	3	altering	alter	VBG
cord-015021-pol2qm74	1231	4	the	the	DT
cord-015021-pol2qm74	1231	5	host	host	NN
cord-015021-pol2qm74	1231	6	response	response	NN
cord-015021-pol2qm74	1231	7	by	by	IN
cord-015021-pol2qm74	1231	8	modulating	modulate	VBG
cord-015021-pol2qm74	1231	9	the	the	DT
cord-015021-pol2qm74	1231	10	function	function	NN
cord-015021-pol2qm74	1231	11	of	of	IN
cord-015021-pol2qm74	1231	12	adhesion	adhesion	NN
cord-015021-pol2qm74	1231	13	molecules	molecule	NNS
cord-015021-pol2qm74	1231	14	may	may	MD
cord-015021-pol2qm74	1231	15	attenuate	attenuate	VB
cord-015021-pol2qm74	1231	16	the	the	DT
cord-015021-pol2qm74	1231	17	inadvertent	inadvertent	JJ
cord-015021-pol2qm74	1231	18	injury	injury	NN
cord-015021-pol2qm74	1231	19	caused	cause	VBN
cord-015021-pol2qm74	1231	20	by	by	IN
cord-015021-pol2qm74	1231	21	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	1231	22	behavior	behavior	NN
cord-015021-pol2qm74	1231	23	of	of	IN
cord-015021-pol2qm74	1231	24	host	host	NN
cord-015021-pol2qm74	1231	25	defense	defense	NN
cord-015021-pol2qm74	1231	26	cells	cell	NNS
cord-015021-pol2qm74	1231	27	.	.	.
cord-015021-pol2qm74	1232	1	Targeting	target	VBG
cord-015021-pol2qm74	1232	2	cellular	cellular	JJ
cord-015021-pol2qm74	1232	3	surface	surface	NN
cord-015021-pol2qm74	1232	4	interactions	interaction	NNS
cord-015021-pol2qm74	1232	5	has	have	VBZ
cord-015021-pol2qm74	1232	6	been	be	VBN
cord-015021-pol2qm74	1232	7	added	add	VBN
cord-015021-pol2qm74	1232	8	to	to	IN
cord-015021-pol2qm74	1232	9	the	the	DT
cord-015021-pol2qm74	1232	10	efforts	effort	NNS
cord-015021-pol2qm74	1232	11	to	to	TO
cord-015021-pol2qm74	1232	12	change	change	VB
cord-015021-pol2qm74	1232	13	the	the	DT
cord-015021-pol2qm74	1232	14	outcome	outcome	NN
cord-015021-pol2qm74	1232	15	of	of	IN
cord-015021-pol2qm74	1232	16	disease	disease	NN
cord-015021-pol2qm74	1232	17	.	.	.
cord-015021-pol2qm74	1233	1	Modulation	modulation	NN
cord-015021-pol2qm74	1233	2	oftheseprocesses	oftheseprocesse	NNS
cord-015021-pol2qm74	1233	3	seems	seem	VBZ
cord-015021-pol2qm74	1233	4	very	very	RB
cord-015021-pol2qm74	1233	5	promising	promising	JJ
cord-015021-pol2qm74	1233	6	,	,	,
cord-015021-pol2qm74	1233	7	but	but	CC
cord-015021-pol2qm74	1233	8	may	may	MD
cord-015021-pol2qm74	1233	9	temporarily	temporarily	RB
cord-015021-pol2qm74	1233	10	leave	leave	VB
cord-015021-pol2qm74	1233	11	the	the	DT
cord-015021-pol2qm74	1233	12	host	host	NN
cord-015021-pol2qm74	1233	13	without	without	IN
cord-015021-pol2qm74	1233	14	effective	effective	JJ
cord-015021-pol2qm74	1233	15	defense	defense	NN
cord-015021-pol2qm74	1233	16	mechanism	mechanism	NN
cord-015021-pol2qm74	1233	17	.	.	.
cord-015021-pol2qm74	1234	1	Great	great	JJ
cord-015021-pol2qm74	1234	2	care	care	NN
cord-015021-pol2qm74	1234	3	therefore	therefore	RB
cord-015021-pol2qm74	1234	4	,	,	,
cord-015021-pol2qm74	1234	5	must	must	MD
cord-015021-pol2qm74	1234	6	be	be	VB
cord-015021-pol2qm74	1234	7	exerted	exert	VBN
cord-015021-pol2qm74	1234	8	when	when	WRB
cord-015021-pol2qm74	1234	9	studying	study	VBG
cord-015021-pol2qm74	1234	10	this	this	DT
cord-015021-pol2qm74	1234	11	powerful	powerful	JJ
cord-015021-pol2qm74	1234	12	two	two	CD
cord-015021-pol2qm74	1234	13	-	-	HYPH
cord-015021-pol2qm74	1234	14	edged	edge	VBN
cord-015021-pol2qm74	1234	15	sword	sword	NN
cord-015021-pol2qm74	1234	16	in	in	IN
cord-015021-pol2qm74	1234	17	a	a	DT
cord-015021-pol2qm74	1234	18	clinical	clinical	JJ
cord-015021-pol2qm74	1234	19	setting	setting	NN
cord-015021-pol2qm74	1234	20	.	.	.
cord-015021-pol2qm74	1235	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	1235	2	knowledge	knowledge	NN
cord-015021-pol2qm74	1235	3	of	of	IN
cord-015021-pol2qm74	1235	4	the	the	DT
cord-015021-pol2qm74	1235	5	role	role	NN
cord-015021-pol2qm74	1235	6	of	of	IN
cord-015021-pol2qm74	1235	7	adhesion	adhesion	NN
cord-015021-pol2qm74	1235	8	molecules	molecule	NNS
cord-015021-pol2qm74	1235	9	in	in	IN
cord-015021-pol2qm74	1235	10	the	the	DT
cord-015021-pol2qm74	1235	11	intlammatory	intlammatory	JJ
cord-015021-pol2qm74	1235	12	response	response	NN
cord-015021-pol2qm74	1235	13	has	have	VBZ
cord-015021-pol2qm74	1235	14	increased	increase	VBN
cord-015021-pol2qm74	1235	15	rapidly	rapidly	RB
cord-015021-pol2qm74	1235	16	due	due	IN
cord-015021-pol2qm74	1235	17	to	to	IN
cord-015021-pol2qm74	1235	18	the	the	DT
cord-015021-pol2qm74	1235	19	availability	availability	NN
cord-015021-pol2qm74	1235	20	of	of	IN
cord-015021-pol2qm74	1235	21	new	new	JJ
cord-015021-pol2qm74	1235	22	reagents	reagent	NNS
cord-015021-pol2qm74	1235	23	and	and	CC
cord-015021-pol2qm74	1235	24	mice	mouse	NNS
cord-015021-pol2qm74	1235	25	geneticly	geneticly	VBN
cord-015021-pol2qm74	1235	26	deficient	deficient	JJ
cord-015021-pol2qm74	1235	27	in	in	IN
cord-015021-pol2qm74	1235	28	adhesion	adhesion	NN
cord-015021-pol2qm74	1235	29	molecules	molecule	NNS
cord-015021-pol2qm74	1235	30	.	.	.
cord-015021-pol2qm74	1236	1	These	these	DT
cord-015021-pol2qm74	1236	2	molecules	molecule	NNS
cord-015021-pol2qm74	1236	3	are	be	VBP
cord-015021-pol2qm74	1236	4	important	important	JJ
cord-015021-pol2qm74	1236	5	in	in	IN
cord-015021-pol2qm74	1236	6	interactions	interaction	NNS
cord-015021-pol2qm74	1236	7	of	of	IN
cord-015021-pol2qm74	1236	8	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1236	9	with	with	IN
cord-015021-pol2qm74	1236	10	endothelial	endothelial	JJ
cord-015021-pol2qm74	1236	11	cells	cell	NNS
cord-015021-pol2qm74	1236	12	,	,	,
cord-015021-pol2qm74	1236	13	other	other	JJ
cord-015021-pol2qm74	1236	14	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1236	15	,	,	,
cord-015021-pol2qm74	1236	16	platelets	platelet	NNS
cord-015021-pol2qm74	1236	17	,	,	,
cord-015021-pol2qm74	1236	18	and	and	CC
cord-015021-pol2qm74	1236	19	epithelial	epithelial	JJ
cord-015021-pol2qm74	1236	20	cells	cell	NNS
cord-015021-pol2qm74	1236	21	.	.	.
cord-015021-pol2qm74	1237	1	When	when	WRB
cord-015021-pol2qm74	1237	2	these	these	DT
cord-015021-pol2qm74	1237	3	molecules	molecule	NNS
cord-015021-pol2qm74	1237	4	are	be	VBP
cord-015021-pol2qm74	1237	5	engaged	engage	VBN
cord-015021-pol2qm74	1237	6	,	,	,
cord-015021-pol2qm74	1237	7	they	-PRON-	PRP
cord-015021-pol2qm74	1237	8	can	can	MD
cord-015021-pol2qm74	1237	9	also	also	RB
cord-015021-pol2qm74	1237	10	play	play	VB
cord-015021-pol2qm74	1237	11	a	a	DT
cord-015021-pol2qm74	1237	12	role	role	NN
cord-015021-pol2qm74	1237	13	in	in	IN
cord-015021-pol2qm74	1237	14	activating	activate	VBG
cord-015021-pol2qm74	1237	15	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1237	16	and	and	CC
cord-015021-pol2qm74	1237	17	their	-PRON-	PRP$
cord-015021-pol2qm74	1237	18	effector	effector	NN
cord-015021-pol2qm74	1237	19	functions	function	NNS
cord-015021-pol2qm74	1237	20	.	.	.
cord-015021-pol2qm74	1238	1	In	in	IN
cord-015021-pol2qm74	1238	2	the	the	DT
cord-015021-pol2qm74	1238	3	venules	venule	NNS
cord-015021-pol2qm74	1238	4	of	of	IN
cord-015021-pol2qm74	1238	5	the	the	DT
cord-015021-pol2qm74	1238	6	systemic	systemic	JJ
cord-015021-pol2qm74	1238	7	circulation	circulation	NN
cord-015021-pol2qm74	1238	8	,	,	,
cord-015021-pol2qm74	1238	9	adhesion	adhesion	NN
cord-015021-pol2qm74	1238	10	often	often	RB
cord-015021-pol2qm74	1238	11	occurs	occur	VBZ
cord-015021-pol2qm74	1238	12	through	through	IN
cord-015021-pol2qm74	1238	13	a	a	DT
cord-015021-pol2qm74	1238	14	series	series	NN
cord-015021-pol2qm74	1238	15	of	of	IN
cord-015021-pol2qm74	1238	16	sequential	sequential	JJ
cord-015021-pol2qm74	1238	17	interactions	interaction	NNS
cord-015021-pol2qm74	1238	18	.	.	.
cord-015021-pol2qm74	1239	1	Initial	initial	JJ
cord-015021-pol2qm74	1239	2	interactions	interaction	NNS
cord-015021-pol2qm74	1239	3	are	be	VBP
cord-015021-pol2qm74	1239	4	mediated	mediate	VBN
cord-015021-pol2qm74	1239	5	by	by	IN
cord-015021-pol2qm74	1239	6	members	member	NNS
cord-015021-pol2qm74	1239	7	of	of	IN
cord-015021-pol2qm74	1239	8	the	the	DT
cord-015021-pol2qm74	1239	9	selectin	selectin	NNP
cord-015021-pol2qm74	1239	10	family	family	NN
cord-015021-pol2qm74	1239	11	to	to	TO
cord-015021-pol2qm74	1239	12	loosely	loosely	RB
cord-015021-pol2qm74	1239	13	associate	associate	VB
cord-015021-pol2qm74	1239	14	the	the	DT
cord-015021-pol2qm74	1239	15	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1239	16	with	with	IN
cord-015021-pol2qm74	1239	17	the	the	DT
cord-015021-pol2qm74	1239	18	endothelium	endothelium	NN
cord-015021-pol2qm74	1239	19	and	and	CC
cord-015021-pol2qm74	1239	20	are	be	VBP
cord-015021-pol2qm74	1239	21	followed	follow	VBN
cord-015021-pol2qm74	1239	22	by	by	IN
cord-015021-pol2qm74	1239	23	firm	firm	JJ
cord-015021-pol2qm74	1239	24	adhesion	adhesion	NN
cord-015021-pol2qm74	1239	25	requiring	require	VBG
cord-015021-pol2qm74	1239	26	members	member	NNS
cord-015021-pol2qm74	1239	27	of	of	IN
cord-015021-pol2qm74	1239	28	the	the	DT
cord-015021-pol2qm74	1239	29	integrin	integrin	NN
cord-015021-pol2qm74	1239	30	and	and	CC
cord-015021-pol2qm74	1239	31	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	1239	32	family	family	NN
cord-015021-pol2qm74	1239	33	.	.	.
cord-015021-pol2qm74	1240	1	Later	later	JJ
cord-015021-pol2qm74	1240	2	interactions	interaction	NNS
cord-015021-pol2qm74	1240	3	with	with	IN
cord-015021-pol2qm74	1240	4	endothelium	endothelium	NN
cord-015021-pol2qm74	1240	5	may	may	MD
cord-015021-pol2qm74	1240	6	require	require	VB
cord-015021-pol2qm74	1240	7	PECAM	PECAM	NNP
cord-015021-pol2qm74	1240	8	.	.	.
cord-015021-pol2qm74	1241	1	Adhesion	adhesion	NN
cord-015021-pol2qm74	1241	2	molecules	molecule	NNS
cord-015021-pol2qm74	1241	3	are	be	VBP
cord-015021-pol2qm74	1241	4	usually	usually	RB
cord-015021-pol2qm74	1241	5	required	require	VBN
cord-015021-pol2qm74	1241	6	for	for	IN
cord-015021-pol2qm74	1241	7	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1241	8	emigration	emigration	NN
cord-015021-pol2qm74	1241	9	in	in	IN
cord-015021-pol2qm74	1241	10	response	response	NN
cord-015021-pol2qm74	1241	11	to	to	IN
cord-015021-pol2qm74	1241	12	extravascular	extravascular	JJ
cord-015021-pol2qm74	1241	13	stimuli	stimulus	NNS
cord-015021-pol2qm74	1241	14	and	and	CC
cord-015021-pol2qm74	1241	15	for	for	IN
cord-015021-pol2qm74	1241	16	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1241	17	-	-	HYPH
cord-015021-pol2qm74	1241	18	mediated	mediate	VBN
cord-015021-pol2qm74	1241	19	endothelial	endothelial	JJ
cord-015021-pol2qm74	1241	20	cell	cell	NN
cord-015021-pol2qm74	1241	21	injury	injury	NN
cord-015021-pol2qm74	1241	22	.	.	.
cord-015021-pol2qm74	1242	1	They	-PRON-	PRP
cord-015021-pol2qm74	1242	2	are	be	VBP
cord-015021-pol2qm74	1242	3	critical	critical	JJ
cord-015021-pol2qm74	1242	4	for	for	IN
cord-015021-pol2qm74	1242	5	host	host	NN
cord-015021-pol2qm74	1242	6	response	response	NN
cord-015021-pol2qm74	1242	7	in	in	IN
cord-015021-pol2qm74	1242	8	many	many	JJ
cord-015021-pol2qm74	1242	9	diseases	disease	NNS
cord-015021-pol2qm74	1242	10	including	include	VBG
cord-015021-pol2qm74	1242	11	infections	infection	NNS
cord-015021-pol2qm74	1242	12	.	.	.
cord-015021-pol2qm74	1243	1	However	however	RB
cord-015021-pol2qm74	1243	2	,	,	,
cord-015021-pol2qm74	1243	3	when	when	WRB
cord-015021-pol2qm74	1243	4	the	the	DT
cord-015021-pol2qm74	1243	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1243	6	response	response	NN
cord-015021-pol2qm74	1243	7	results	result	NNS
cord-015021-pol2qm74	1243	8	in	in	IN
cord-015021-pol2qm74	1243	9	damage	damage	NN
cord-015021-pol2qm74	1243	10	to	to	IN
cord-015021-pol2qm74	1243	11	host	host	NN
cord-015021-pol2qm74	1243	12	tissues	tissue	NNS
cord-015021-pol2qm74	1243	13	,	,	,
cord-015021-pol2qm74	1243	14	patients	patient	NNS
cord-015021-pol2qm74	1243	15	may	may	MD
cord-015021-pol2qm74	1243	16	benefit	benefit	VB
cord-015021-pol2qm74	1243	17	from	from	IN
cord-015021-pol2qm74	1243	18	blocking	block	VBG
cord-015021-pol2qm74	1243	19	the	the	DT
cord-015021-pol2qm74	1243	20	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1243	21	response	response	NN
cord-015021-pol2qm74	1243	22	.	.	.
cord-015021-pol2qm74	1244	1	Anti	anti	JJ
cord-015021-pol2qm74	1244	2	-	-	JJ
cord-015021-pol2qm74	1244	3	adhesion	adhesion	NN
cord-015021-pol2qm74	1244	4	molecule	molecule	NN
cord-015021-pol2qm74	1244	5	agents	agent	NNS
cord-015021-pol2qm74	1244	6	are	be	VBP
cord-015021-pol2qm74	1244	7	an	an	DT
cord-015021-pol2qm74	1244	8	important	important	JJ
cord-015021-pol2qm74	1244	9	potential	potential	JJ
cord-015021-pol2qm74	1244	10	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	1244	11	therapy	therapy	NN
cord-015021-pol2qm74	1244	12	.	.	.
cord-015021-pol2qm74	1245	1	The	the	DT
cord-015021-pol2qm74	1245	2	focus	focus	NN
cord-015021-pol2qm74	1245	3	of	of	IN
cord-015021-pol2qm74	1245	4	anti	anti	JJ
cord-015021-pol2qm74	1245	5	-	-	JJ
cord-015021-pol2qm74	1245	6	adhesion	adhesion	JJ
cord-015021-pol2qm74	1245	7	therapy	therapy	NN
cord-015021-pol2qm74	1245	8	may	may	MD
cord-015021-pol2qm74	1245	9	be	be	VB
cord-015021-pol2qm74	1245	10	at	at	IN
cord-015021-pol2qm74	1245	11	any	any	DT
cord-015021-pol2qm74	1245	12	step	step	NN
cord-015021-pol2qm74	1245	13	of	of	IN
cord-015021-pol2qm74	1245	14	the	the	DT
cord-015021-pol2qm74	1245	15	sequence	sequence	NN
cord-015021-pol2qm74	1245	16	.	.	.
cord-015021-pol2qm74	1246	1	Diseases	disease	NNS
cord-015021-pol2qm74	1246	2	where	where	WRB
cord-015021-pol2qm74	1246	3	anti	anti	JJ
cord-015021-pol2qm74	1246	4	-	-	JJ
cord-015021-pol2qm74	1246	5	adhesion	adhesion	JJ
cord-015021-pol2qm74	1246	6	molecule	molecule	NN
cord-015021-pol2qm74	1246	7	therapy	therapy	NN
cord-015021-pol2qm74	1246	8	may	may	MD
cord-015021-pol2qm74	1246	9	benefit	benefit	VB
cord-015021-pol2qm74	1246	10	patients	patient	NNS
cord-015021-pol2qm74	1246	11	include	include	VBP
cord-015021-pol2qm74	1246	12	ischemia	ischemia	NN
cord-015021-pol2qm74	1246	13	/	/	SYM
cord-015021-pol2qm74	1246	14	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1246	15	injury	injury	NN
cord-015021-pol2qm74	1246	16	in	in	IN
cord-015021-pol2qm74	1246	17	many	many	JJ
cord-015021-pol2qm74	1246	18	organs	organ	NNS
cord-015021-pol2qm74	1246	19	,	,	,
cord-015021-pol2qm74	1246	20	ARDS	ARDS	NNP
cord-015021-pol2qm74	1246	21	and	and	CC
cord-015021-pol2qm74	1246	22	MOF	MOF	NNP
cord-015021-pol2qm74	1246	23	,	,	,
cord-015021-pol2qm74	1246	24	and	and	CC
cord-015021-pol2qm74	1246	25	transplantation	transplantation	NN
cord-015021-pol2qm74	1246	26	,	,	,
cord-015021-pol2qm74	1246	27	both	both	DT
cord-015021-pol2qm74	1246	28	to	to	TO
cord-015021-pol2qm74	1246	29	protect	protect	VB
cord-015021-pol2qm74	1246	30	the	the	DT
cord-015021-pol2qm74	1246	31	donor	donor	NN
cord-015021-pol2qm74	1246	32	organ	organ	NN
cord-015021-pol2qm74	1246	33	from	from	IN
cord-015021-pol2qm74	1246	34	ischemia	ischemia	NN
cord-015021-pol2qm74	1246	35	/	/	SYM
cord-015021-pol2qm74	1246	36	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1246	37	injury	injury	NN
cord-015021-pol2qm74	1246	38	and	and	CC
cord-015021-pol2qm74	1246	39	to	to	TO
cord-015021-pol2qm74	1246	40	inhibit	inhibit	VB
cord-015021-pol2qm74	1246	41	graft	graft	NN
cord-015021-pol2qm74	1246	42	vs	vs	IN
cord-015021-pol2qm74	1246	43	host	host	NN
cord-015021-pol2qm74	1246	44	disease	disease	NN
cord-015021-pol2qm74	1246	45	.	.	.
cord-015021-pol2qm74	1247	1	Many	many	JJ
cord-015021-pol2qm74	1247	2	strategies	strategy	NNS
cord-015021-pol2qm74	1247	3	have	have	VBP
cord-015021-pol2qm74	1247	4	been	be	VBN
cord-015021-pol2qm74	1247	5	considered	consider	VBN
cord-015021-pol2qm74	1247	6	and	and	CC
cord-015021-pol2qm74	1247	7	include	include	VBP
cord-015021-pol2qm74	1247	8	:	:	:
cord-015021-pol2qm74	1247	9	1	1	LS
cord-015021-pol2qm74	1247	10	)	)	-RRB-
cord-015021-pol2qm74	1247	11	blocking	block	VBG
cord-015021-pol2qm74	1247	12	the	the	DT
cord-015021-pol2qm74	1247	13	ability	ability	NN
cord-015021-pol2qm74	1247	14	of	of	IN
cord-015021-pol2qm74	1247	15	adhesion	adhesion	NN
cord-015021-pol2qm74	1247	16	molecules	molecule	NNS
cord-015021-pol2qm74	1247	17	to	to	TO
cord-015021-pol2qm74	1247	18	recognize	recognize	VB
cord-015021-pol2qm74	1247	19	their	-PRON-	PRP$
cord-015021-pol2qm74	1247	20	ligand	ligand	NN
cord-015021-pol2qm74	1247	21	using	use	VBG
cord-015021-pol2qm74	1247	22	antibodies	antibody	NNS
cord-015021-pol2qm74	1247	23	that	that	WDT
cord-015021-pol2qm74	1247	24	have	have	VBP
cord-015021-pol2qm74	1247	25	been	be	VBN
cord-015021-pol2qm74	1247	26	humanized	humanize	VBN
cord-015021-pol2qm74	1247	27	or	or	CC
cord-015021-pol2qm74	1247	28	soluble	soluble	JJ
cord-015021-pol2qm74	1247	29	receptors	receptor	NNS
cord-015021-pol2qm74	1247	30	linked	link	VBN
cord-015021-pol2qm74	1247	31	to	to	IN
cord-015021-pol2qm74	1247	32	IgG	IgG	NNP
cord-015021-pol2qm74	1247	33	to	to	TO
cord-015021-pol2qm74	1247	34	prolong	prolong	VB
cord-015021-pol2qm74	1247	35	their	-PRON-	PRP$
cord-015021-pol2qm74	1247	36	circulating	circulate	VBG
cord-015021-pol2qm74	1247	37	halflife	halflife	NN
cord-015021-pol2qm74	1247	38	,	,	,
cord-015021-pol2qm74	1247	39	2	2	LS
cord-015021-pol2qm74	1247	40	)	)	-RRB-
cord-015021-pol2qm74	1247	41	blocking	block	VBG
cord-015021-pol2qm74	1247	42	the	the	DT
cord-015021-pol2qm74	1247	43	ligands	ligand	NNS
cord-015021-pol2qm74	1247	44	for	for	IN
cord-015021-pol2qm74	1247	45	adhesion	adhesion	NN
cord-015021-pol2qm74	1247	46	molecules	molecule	NNS
cord-015021-pol2qm74	1247	47	using	use	VBG
cord-015021-pol2qm74	1247	48	soluble	soluble	JJ
cord-015021-pol2qm74	1247	49	adhesion	adhesion	NN
cord-015021-pol2qm74	1247	50	molecules	molecule	NNS
cord-015021-pol2qm74	1247	51	,	,	,
cord-015021-pol2qm74	1247	52	peptide	peptide	JJ
cord-015021-pol2qm74	1247	53	analogues	analogue	NNS
cord-015021-pol2qm74	1247	54	,	,	,
cord-015021-pol2qm74	1247	55	or	or	CC
cord-015021-pol2qm74	1247	56	oligosaccharides	oligosaccharide	NNS
cord-015021-pol2qm74	1247	57	,	,	,
cord-015021-pol2qm74	1247	58	and	and	CC
cord-015021-pol2qm74	1247	59	3	3	LS
cord-015021-pol2qm74	1247	60	)	)	-RRB-
cord-015021-pol2qm74	1247	61	blocking	block	VBG
cord-015021-pol2qm74	1247	62	the	the	DT
cord-015021-pol2qm74	1247	63	production	production	NN
cord-015021-pol2qm74	1247	64	of	of	IN
cord-015021-pol2qm74	1247	65	the	the	DT
cord-015021-pol2qm74	1247	66	adhesion	adhesion	NN
cord-015021-pol2qm74	1247	67	molecule	molecule	NN
cord-015021-pol2qm74	1247	68	using	use	VBG
cord-015021-pol2qm74	1247	69	anti	anti	JJ
cord-015021-pol2qm74	1247	70	-	-	JJ
cord-015021-pol2qm74	1247	71	sense	sense	JJ
cord-015021-pol2qm74	1247	72	oligonucleotides	oligonucleotide	NNS
cord-015021-pol2qm74	1247	73	.	.	.
cord-015021-pol2qm74	1248	1	Because	because	IN
cord-015021-pol2qm74	1248	2	the	the	DT
cord-015021-pol2qm74	1248	3	synthesis	synthesis	NN
cord-015021-pol2qm74	1248	4	of	of	IN
cord-015021-pol2qm74	1248	5	adhesion	adhesion	NN
cord-015021-pol2qm74	1248	6	molecules	molecule	NNS
cord-015021-pol2qm74	1248	7	is	be	VBZ
cord-015021-pol2qm74	1248	8	usually	usually	RB
cord-015021-pol2qm74	1248	9	regulated	regulate	VBN
cord-015021-pol2qm74	1248	10	by	by	IN
cord-015021-pol2qm74	1248	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	1248	12	,	,	,
cord-015021-pol2qm74	1248	13	inhibiting	inhibit	VBG
cord-015021-pol2qm74	1248	14	the	the	DT
cord-015021-pol2qm74	1248	15	action	action	NN
cord-015021-pol2qm74	1248	16	of	of	IN
cord-015021-pol2qm74	1248	17	cytokines	cytokine	NNS
cord-015021-pol2qm74	1248	18	is	be	VBZ
cord-015021-pol2qm74	1248	19	another	another	DT
cord-015021-pol2qm74	1248	20	potential	potential	JJ
cord-015021-pol2qm74	1248	21	site	site	NN
cord-015021-pol2qm74	1248	22	for	for	IN
cord-015021-pol2qm74	1248	23	interrupting	interrupt	VBG
cord-015021-pol2qm74	1248	24	the	the	DT
cord-015021-pol2qm74	1248	25	adhesion	adhesion	NN
cord-015021-pol2qm74	1248	26	process	process	NN
cord-015021-pol2qm74	1248	27	.	.	.
cord-015021-pol2qm74	1249	1	Although	although	IN
cord-015021-pol2qm74	1249	2	important	important	JJ
cord-015021-pol2qm74	1249	3	issues	issue	NNS
cord-015021-pol2qm74	1249	4	of	of	IN
cord-015021-pol2qm74	1249	5	safety	safety	NN
cord-015021-pol2qm74	1249	6	must	must	MD
cord-015021-pol2qm74	1249	7	be	be	VB
cord-015021-pol2qm74	1249	8	evaluated	evaluate	VBN
cord-015021-pol2qm74	1249	9	,	,	,
cord-015021-pol2qm74	1249	10	the	the	DT
cord-015021-pol2qm74	1249	11	potential	potential	NN
cord-015021-pol2qm74	1249	12	for	for	IN
cord-015021-pol2qm74	1249	13	modulating	modulate	VBG
cord-015021-pol2qm74	1249	14	the	the	DT
cord-015021-pol2qm74	1249	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1249	16	response	response	NN
cord-015021-pol2qm74	1249	17	make	make	VBP
cord-015021-pol2qm74	1249	18	this	this	DT
cord-015021-pol2qm74	1249	19	an	an	DT
cord-015021-pol2qm74	1249	20	exciting	exciting	JJ
cord-015021-pol2qm74	1249	21	area	area	NN
cord-015021-pol2qm74	1249	22	of	of	IN
cord-015021-pol2qm74	1249	23	improvement	improvement	NN
cord-015021-pol2qm74	1249	24	in	in	IN
cord-015021-pol2qm74	1249	25	health	health	NN
cord-015021-pol2qm74	1249	26	care	care	NN
cord-015021-pol2qm74	1249	27	delivery	delivery	NN
cord-015021-pol2qm74	1249	28	.	.	.
cord-015021-pol2qm74	1250	1	Claire	Claire	NNP
cord-015021-pol2qm74	1250	2	M.	M.	NNP
cord-015021-pol2qm74	1250	3	Doerschuk	Doerschuk	NNP
cord-015021-pol2qm74	1250	4	,	,	,
cord-015021-pol2qm74	1250	5	M.D.	M.D.	NNP
cord-015021-pol2qm74	1250	6	;	;	:
cord-015021-pol2qm74	1250	7	Riley	Riley	NNP
cord-015021-pol2qm74	1250	8	Hospital	Hospital	NNP
cord-015021-pol2qm74	1250	9	for	for	IN
cord-015021-pol2qm74	1250	10	Children	Children	NNP
cord-015021-pol2qm74	1250	11	,	,	,
cord-015021-pol2qm74	1250	12	Room	room	NN
cord-015021-pol2qm74	1250	13	2600	2600	CD
cord-015021-pol2qm74	1250	14	;	;	:
cord-015021-pol2qm74	1250	15	702	702	CD
cord-015021-pol2qm74	1250	16	Barnhill	Barnhill	NNP
cord-015021-pol2qm74	1250	17	Drive	Drive	NNP
cord-015021-pol2qm74	1250	18	;	;	:
cord-015021-pol2qm74	1250	19	Indianapolis	Indianapolis	NNP
cord-015021-pol2qm74	1250	20	,	,	,
cord-015021-pol2qm74	1250	21	IN	in	IN
cord-015021-pol2qm74	1250	22	46202	46202	CD
cord-015021-pol2qm74	1250	23	USA	USA	NNP
cord-015021-pol2qm74	1250	24	.	.	.
cord-015021-pol2qm74	1251	1	Modulation	modulation	NN
cord-015021-pol2qm74	1251	2	of	of	IN
cord-015021-pol2qm74	1251	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1251	4	-	-	HYPH
cord-015021-pol2qm74	1251	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	1251	6	cell	cell	NN
cord-015021-pol2qm74	1251	7	adhesion	adhesion	NN
cord-015021-pol2qm74	1251	8	with	with	IN
cord-015021-pol2qm74	1251	9	anti	anti	JJ
cord-015021-pol2qm74	1251	10	-	-	NNS
cord-015021-pol2qm74	1251	11	CDl	CDl	NNS
cord-015021-pol2qm74	1251	12	I	I	NNP
cord-015021-pol2qm74	1251	13	/	/	SYM
cord-015021-pol2qm74	1251	14	CD18	CD18	NNP
cord-015021-pol2qm74	1251	15	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1251	16	antibodies	antibody	NNS
cord-015021-pol2qm74	1251	17	as	as	IN
cord-015021-pol2qm74	1251	18	a	a	DT
cord-015021-pol2qm74	1251	19	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1251	20	modality	modality	NN
cord-015021-pol2qm74	1251	21	.	.	.
cord-015021-pol2qm74	1252	1	CH	CH	NNP
cord-015021-pol2qm74	1252	2	Wortel	Wortel	NNP
cord-015021-pol2qm74	1252	3	,	,	,
cord-015021-pol2qm74	1252	4	Repligen	Repligen	NNP
cord-015021-pol2qm74	1252	5	Corporation	Corporation	NNP
cord-015021-pol2qm74	1252	6	,	,	,
cord-015021-pol2qm74	1252	7	One	one	CD
cord-015021-pol2qm74	1252	8	Kendall	Kendall	NNP
cord-015021-pol2qm74	1252	9	Square	Square	NNP
cord-015021-pol2qm74	1252	10	,	,	,
cord-015021-pol2qm74	1252	11	Building	Building	NNP
cord-015021-pol2qm74	1252	12	700	700	CD
cord-015021-pol2qm74	1252	13	,	,	,
cord-015021-pol2qm74	1252	14	Cambridge	Cambridge	NNP
cord-015021-pol2qm74	1252	15	,	,	,
cord-015021-pol2qm74	1252	16	MA	MA	NNP
cord-015021-pol2qm74	1252	17	02139	02139	CD
cord-015021-pol2qm74	1252	18	,	,	,
cord-015021-pol2qm74	1252	19	USA	USA	NNP
cord-015021-pol2qm74	1252	20	.	.	.
cord-015021-pol2qm74	1253	1	The	the	DT
cord-015021-pol2qm74	1253	2	central	central	JJ
cord-015021-pol2qm74	1253	3	role	role	NN
cord-015021-pol2qm74	1253	4	of	of	IN
cord-015021-pol2qm74	1253	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1253	6	cells	cell	NNS
cord-015021-pol2qm74	1253	7	in	in	IN
cord-015021-pol2qm74	1253	8	the	the	DT
cord-015021-pol2qm74	1253	9	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	1253	10	of	of	IN
cord-015021-pol2qm74	1253	11	lung	lung	NN
cord-015021-pol2qm74	1253	12	and	and	CC
cord-015021-pol2qm74	1253	13	systemic	systemic	JJ
cord-015021-pol2qm74	1253	14	organ	organ	NN
cord-015021-pol2qm74	1253	15	injury	injury	NN
cord-015021-pol2qm74	1253	16	is	be	VBZ
cord-015021-pol2qm74	1253	17	well	well	RB
cord-015021-pol2qm74	1253	18	recognized	recognize	VBN
cord-015021-pol2qm74	1253	19	.	.	.
cord-015021-pol2qm74	1254	1	Binding	bind	VBG
cord-015021-pol2qm74	1254	2	of	of	IN
cord-015021-pol2qm74	1254	3	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1254	4	to	to	IN
cord-015021-pol2qm74	1254	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	1254	6	cells	cell	NNS
cord-015021-pol2qm74	1254	7	and	and	CC
cord-015021-pol2qm74	1254	8	migration	migration	NN
cord-015021-pol2qm74	1254	9	into	into	IN
cord-015021-pol2qm74	1254	10	the	the	DT
cord-015021-pol2qm74	1254	11	parenchyma	parenchyma	NN
cord-015021-pol2qm74	1254	12	are	be	VBP
cord-015021-pol2qm74	1254	13	largely	largely	RB
cord-015021-pol2qm74	1254	14	regulated	regulate	VBN
cord-015021-pol2qm74	1254	15	by	by	IN
cord-015021-pol2qm74	1254	16	complementary	complementary	JJ
cord-015021-pol2qm74	1254	17	adhesion	adhesion	NN
cord-015021-pol2qm74	1254	18	molecules	molecule	NNS
cord-015021-pol2qm74	1254	19	.	.	.
cord-015021-pol2qm74	1255	1	The	the	DT
cord-015021-pol2qm74	1255	2	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1255	3	integrins	integrin	NNS
cord-015021-pol2qm74	1255	4	are	be	VBP
cord-015021-pol2qm74	1255	5	glycoproteins	glycoprotein	NNS
cord-015021-pol2qm74	1255	6	expressed	express	VBN
cord-015021-pol2qm74	1255	7	on	on	IN
cord-015021-pol2qm74	1255	8	the	the	DT
cord-015021-pol2qm74	1255	9	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1255	10	surface	surface	NN
cord-015021-pol2qm74	1255	11	and	and	CC
cord-015021-pol2qm74	1255	12	in	in	IN
cord-015021-pol2qm74	1255	13	the	the	DT
cord-015021-pol2qm74	1255	14	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	1255	15	granules	granule	NNS
cord-015021-pol2qm74	1255	16	.	.	.
cord-015021-pol2qm74	1256	1	Integrins	integrin	NNS
cord-015021-pol2qm74	1256	2	consist	consist	VBP
cord-015021-pol2qm74	1256	3	of	of	IN
cord-015021-pol2qm74	1256	4	a	a	DT
cord-015021-pol2qm74	1256	5	common	common	JJ
cord-015021-pol2qm74	1256	6	beta2	beta2	NN
cord-015021-pol2qm74	1256	7	or	or	CC
cord-015021-pol2qm74	1256	8	cluster	cluster	NN
cord-015021-pol2qm74	1256	9	differentiation	differentiation	NN
cord-015021-pol2qm74	1257	1	(	(	-LRB-
cord-015021-pol2qm74	1257	2	CD)18	CD)18	NNP
cord-015021-pol2qm74	1257	3	chain	chain	VBP
cord-015021-pol2qm74	1257	4	covalently	covalently	RB
cord-015021-pol2qm74	1257	5	linked	link	VBN
cord-015021-pol2qm74	1257	6	to	to	IN
cord-015021-pol2qm74	1257	7	one	one	CD
cord-015021-pol2qm74	1257	8	of	of	IN
cord-015021-pol2qm74	1257	9	three	three	CD
cord-015021-pol2qm74	1257	10	different	different	JJ
cord-015021-pol2qm74	1257	11	alpha	alpha	NN
cord-015021-pol2qm74	1257	12	chains	chain	NNS
cord-015021-pol2qm74	1257	13	(	(	-LRB-
cord-015021-pol2qm74	1257	14	CDlla	CDlla	NNPS
cord-015021-pol2qm74	1257	15	,	,	,
cord-015021-pol2qm74	1257	16	CDllb	CDllb	NNP
cord-015021-pol2qm74	1257	17	,	,	,
cord-015021-pol2qm74	1257	18	CDIlc	CDIlc	NNP
cord-015021-pol2qm74	1257	19	)	)	-RRB-
cord-015021-pol2qm74	1257	20	and	and	CC
cord-015021-pol2qm74	1257	21	exist	exist	VB
cord-015021-pol2qm74	1257	22	on	on	IN
cord-015021-pol2qm74	1257	23	the	the	DT
cord-015021-pol2qm74	1257	24	cell	cell	NN
cord-015021-pol2qm74	1257	25	surface	surface	NN
cord-015021-pol2qm74	1257	26	as	as	IN
cord-015021-pol2qm74	1257	27	three	three	CD
cord-015021-pol2qm74	1257	28	distinct	distinct	JJ
cord-015021-pol2qm74	1257	29	heterodimers	heterodimer	NNS
cord-015021-pol2qm74	1257	30	.	.	.
cord-015021-pol2qm74	1258	1	CDlla/	CDlla/	NNPS
cord-015021-pol2qm74	1259	1	CD18	CD18	NNP
cord-015021-pol2qm74	1259	2	is	be	VBZ
cord-015021-pol2qm74	1259	3	expressed	express	VBN
cord-015021-pol2qm74	1259	4	on	on	IN
cord-015021-pol2qm74	1259	5	all	all	DT
cord-015021-pol2qm74	1259	6	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1259	7	,	,	,
cord-015021-pol2qm74	1259	8	whereas	whereas	IN
cord-015021-pol2qm74	1259	9	CD	CD	NNP
cord-015021-pol2qm74	1259	10	11	11	CD
cord-015021-pol2qm74	1259	11	b	b	NN
cord-015021-pol2qm74	1259	12	/	/	SYM
cord-015021-pol2qm74	1259	13	CD	CD	NNP
cord-015021-pol2qm74	1259	14	18	18	CD
cord-015021-pol2qm74	1259	15	and	and	CC
cord-015021-pol2qm74	1259	16	CD	CD	NNP
cord-015021-pol2qm74	1259	17	11	11	CD
cord-015021-pol2qm74	1260	1	c	c	NNP
cord-015021-pol2qm74	1260	2	/	/	SYM
cord-015021-pol2qm74	1260	3	CD	CD	NNP
cord-015021-pol2qm74	1260	4	1.8	1.8	CD
cord-015021-pol2qm74	1260	5	are	be	VBP
cord-015021-pol2qm74	1260	6	restricted	restrict	VBN
cord-015021-pol2qm74	1260	7	to	to	IN
cord-015021-pol2qm74	1260	8	cells	cell	NNS
cord-015021-pol2qm74	1260	9	of	of	IN
cord-015021-pol2qm74	1260	10	myeloid	myeloid	JJ
cord-015021-pol2qm74	1260	11	origin	origin	NN
cord-015021-pol2qm74	1260	12	.	.	.
cord-015021-pol2qm74	1261	1	CD	CD	NNP
cord-015021-pol2qm74	1262	1	i	i	PRP
cord-015021-pol2qm74	1262	2	1/	1/	CD
cord-015021-pol2qm74	1262	3	CD	CD	NNP
cord-015021-pol2qm74	1262	4	18	18	CD
cord-015021-pol2qm74	1262	5	interacts	interact	VBZ
cord-015021-pol2qm74	1262	6	with	with	IN
cord-015021-pol2qm74	1262	7	intracellular	intracellular	JJ
cord-015021-pol2qm74	1262	8	adhesion	adhesion	NN
cord-015021-pol2qm74	1262	9	molecule-1	molecule-1	NN
cord-015021-pol2qm74	1263	1	(	(	-LRB-
cord-015021-pol2qm74	1263	2	ICAM	ICAM	NNP
cord-015021-pol2qm74	1263	3	-	-	HYPH
cord-015021-pol2qm74	1263	4	I	I	NNP
cord-015021-pol2qm74	1263	5	)	)	-RRB-
cord-015021-pol2qm74	1263	6	,	,	,
cord-015021-pol2qm74	1263	7	its	-PRON-	PRP$
cord-015021-pol2qm74	1263	8	ligand	ligand	NN
cord-015021-pol2qm74	1263	9	on	on	IN
cord-015021-pol2qm74	1263	10	endothelial	endothelial	JJ
cord-015021-pol2qm74	1263	11	cells	cell	NNS
cord-015021-pol2qm74	1263	12	.	.	.
cord-015021-pol2qm74	1264	1	The	the	DT
cord-015021-pol2qm74	1264	2	potential	potential	NN
cord-015021-pol2qm74	1264	3	for	for	IN
cord-015021-pol2qm74	1264	4	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1264	5	antibodies	antibody	NNS
cord-015021-pol2qm74	1264	6	to	to	TO
cord-015021-pol2qm74	1264	7	adhesion	adhesion	NN
cord-015021-pol2qm74	1264	8	proteins	protein	NNS
cord-015021-pol2qm74	1264	9	to	to	TO
cord-015021-pol2qm74	1264	10	reduce	reduce	VB
cord-015021-pol2qm74	1264	11	vascular	vascular	JJ
cord-015021-pol2qm74	1264	12	and	and	CC
cord-015021-pol2qm74	1264	13	tissue	tissue	NN
cord-015021-pol2qm74	1264	14	damage	damage	NN
cord-015021-pol2qm74	1264	15	has	have	VBZ
cord-015021-pol2qm74	1264	16	been	be	VBN
cord-015021-pol2qm74	1264	17	studied	study	VBN
cord-015021-pol2qm74	1264	18	in	in	IN
cord-015021-pol2qm74	1264	19	a	a	DT
cord-015021-pol2qm74	1264	20	large	large	JJ
cord-015021-pol2qm74	1264	21	number	number	NN
cord-015021-pol2qm74	1264	22	of	of	IN
cord-015021-pol2qm74	1264	23	experimental	experimental	JJ
cord-015021-pol2qm74	1264	24	models	model	NNS
cord-015021-pol2qm74	1264	25	.	.	.
cord-015021-pol2qm74	1265	1	Protective	protective	JJ
cord-015021-pol2qm74	1265	2	effects	effect	NNS
cord-015021-pol2qm74	1265	3	with	with	IN
cord-015021-pol2qm74	1265	4	anti	anti	JJ
cord-015021-pol2qm74	1265	5	-	-	JJ
cord-015021-pol2qm74	1265	6	CD18	cd18	JJ
cord-015021-pol2qm74	1265	7	antibodies	antibody	NNS
cord-015021-pol2qm74	1265	8	have	have	VBP
cord-015021-pol2qm74	1265	9	been	be	VBN
cord-015021-pol2qm74	1265	10	observed	observe	VBN
cord-015021-pol2qm74	1265	11	in	in	IN
cord-015021-pol2qm74	1265	12	a	a	DT
cord-015021-pol2qm74	1265	13	wide	wide	JJ
cord-015021-pol2qm74	1265	14	variety	variety	NN
cord-015021-pol2qm74	1265	15	of	of	IN
cord-015021-pol2qm74	1265	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1265	17	,	,	,
cord-015021-pol2qm74	1265	18	immune	immune	JJ
cord-015021-pol2qm74	1265	19	,	,	,
cord-015021-pol2qm74	1265	20	and	and	CC
cord-015021-pol2qm74	1265	21	isehemia	isehemia	NN
cord-015021-pol2qm74	1265	22	-	-	HYPH
cord-015021-pol2qm74	1265	23	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1265	24	injuries	injury	NNS
cord-015021-pol2qm74	1265	25	,	,	,
cord-015021-pol2qm74	1265	26	such	such	JJ
cord-015021-pol2qm74	1265	27	as	as	IN
cord-015021-pol2qm74	1265	28	arthritis	arthritis	NN
cord-015021-pol2qm74	1265	29	,	,	,
cord-015021-pol2qm74	1265	30	burns	burn	NNS
cord-015021-pol2qm74	1265	31	,	,	,
cord-015021-pol2qm74	1265	32	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	1265	33	shock	shock	NN
cord-015021-pol2qm74	1265	34	,	,	,
cord-015021-pol2qm74	1265	35	bacterial	bacterial	JJ
cord-015021-pol2qm74	1265	36	meningitis	meningitis	NN
cord-015021-pol2qm74	1265	37	,	,	,
cord-015021-pol2qm74	1265	38	autoimmune	autoimmune	JJ
cord-015021-pol2qm74	1265	39	diabetes	diabetes	NN
cord-015021-pol2qm74	1265	40	,	,	,
cord-015021-pol2qm74	1265	41	nerve	nerve	NN
cord-015021-pol2qm74	1265	42	degenemrion	degenemrion	NN
cord-015021-pol2qm74	1265	43	,	,	,
cord-015021-pol2qm74	1265	44	allograft	allograft	NN
cord-015021-pol2qm74	1265	45	rejection	rejection	NN
cord-015021-pol2qm74	1265	46	,	,	,
cord-015021-pol2qm74	1265	47	allergic	allergic	JJ
cord-015021-pol2qm74	1265	48	asthma	asthma	NN
cord-015021-pol2qm74	1265	49	,	,	,
cord-015021-pol2qm74	1265	50	acute	acute	JJ
cord-015021-pol2qm74	1265	51	lung	lung	NN
cord-015021-pol2qm74	1265	52	inflammation	inflammation	NN
cord-015021-pol2qm74	1265	53	,	,	,
cord-015021-pol2qm74	1265	54	skin	skin	NN
cord-015021-pol2qm74	1265	55	lesions	lesion	NNS
cord-015021-pol2qm74	1265	56	,	,	,
cord-015021-pol2qm74	1265	57	and	and	CC
cord-015021-pol2qm74	1265	58	ischemia	ischemia	NN
cord-015021-pol2qm74	1265	59	-	-	HYPH
cord-015021-pol2qm74	1265	60	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1265	61	models	model	NNS
cord-015021-pol2qm74	1265	62	of	of	IN
cord-015021-pol2qm74	1265	63	the	the	DT
cord-015021-pol2qm74	1265	64	intestine	intestine	NN
cord-015021-pol2qm74	1265	65	,	,	,
cord-015021-pol2qm74	1265	66	myocardium	myocardium	NN
cord-015021-pol2qm74	1265	67	,	,	,
cord-015021-pol2qm74	1265	68	lung	lung	NN
cord-015021-pol2qm74	1265	69	,	,	,
cord-015021-pol2qm74	1265	70	skeletal	skeletal	JJ
cord-015021-pol2qm74	1265	71	muscle	muscle	NN
cord-015021-pol2qm74	1265	72	,	,	,
cord-015021-pol2qm74	1265	73	and	and	CC
cord-015021-pol2qm74	1265	74	central	central	JJ
cord-015021-pol2qm74	1265	75	nervous	nervous	JJ
cord-015021-pol2qm74	1265	76	system	system	NN
cord-015021-pol2qm74	1265	77	.	.	.
cord-015021-pol2qm74	1266	1	Protective	protective	JJ
cord-015021-pol2qm74	1266	2	effects	effect	NNS
cord-015021-pol2qm74	1266	3	have	have	VBP
cord-015021-pol2qm74	1266	4	also	also	RB
cord-015021-pol2qm74	1266	5	been	be	VBN
cord-015021-pol2qm74	1266	6	observed	observe	VBN
cord-015021-pol2qm74	1266	7	in	in	IN
cord-015021-pol2qm74	1266	8	animals	animal	NNS
cord-015021-pol2qm74	1266	9	resuscitated	resuscitate	VBD
cord-015021-pol2qm74	1266	10	following	follow	VBG
cord-015021-pol2qm74	1266	11	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	1266	12	shock	shock	NN
cord-015021-pol2qm74	1266	13	.	.	.
cord-015021-pol2qm74	1267	1	Blockage	blockage	NN
cord-015021-pol2qm74	1267	2	of	of	IN
cord-015021-pol2qm74	1267	3	CD18	CD18	NNP
cord-015021-pol2qm74	1267	4	,	,	,
cord-015021-pol2qm74	1267	5	however	however	RB
cord-015021-pol2qm74	1267	6	,	,	,
cord-015021-pol2qm74	1267	7	would	would	MD
cord-015021-pol2qm74	1267	8	affect	affect	VB
cord-015021-pol2qm74	1267	9	all	all	DT
cord-015021-pol2qm74	1267	10	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1267	11	,	,	,
cord-015021-pol2qm74	1267	12	as	as	IN
cord-015021-pol2qm74	1267	13	would	would	MD
cord-015021-pol2qm74	1267	14	antibodies	antibody	NNS
cord-015021-pol2qm74	1267	15	to	to	IN
cord-015021-pol2qm74	1267	16	CDlla	CDlla	NNP
cord-015021-pol2qm74	1267	17	/	/	SYM
cord-015021-pol2qm74	1267	18	CDI8	CDI8	NNP
cord-015021-pol2qm74	1267	19	.	.	.
cord-015021-pol2qm74	1268	1	Targeting	Targeting	NNP
cord-015021-pol2qm74	1268	2	CDllb	CDllb	NNP
cord-015021-pol2qm74	1268	3	/	/	SYM
cord-015021-pol2qm74	1268	4	CD18	CD18	NNP
cord-015021-pol2qm74	1268	5	would	would	MD
cord-015021-pol2qm74	1268	6	affect	affect	VB
cord-015021-pol2qm74	1268	7	cells	cell	NNS
cord-015021-pol2qm74	1268	8	of	of	IN
cord-015021-pol2qm74	1268	9	the	the	DT
cord-015021-pol2qm74	1268	10	myeloid	myeloid	JJ
cord-015021-pol2qm74	1268	11	lineage	lineage	NN
cord-015021-pol2qm74	1268	12	only	only	RB
cord-015021-pol2qm74	1268	13	,	,	,
cord-015021-pol2qm74	1268	14	which	which	WDT
cord-015021-pol2qm74	1268	15	could	could	MD
cord-015021-pol2qm74	1268	16	prove	prove	VB
cord-015021-pol2qm74	1268	17	to	to	TO
cord-015021-pol2qm74	1268	18	be	be	VB
cord-015021-pol2qm74	1268	19	beneficial	beneficial	JJ
cord-015021-pol2qm74	1268	20	.	.	.
cord-015021-pol2qm74	1269	1	CD11b/	CD11b/	NNS
cord-015021-pol2qm74	1270	1	CD18	CD18	NNP
cord-015021-pol2qm74	1270	2	is	be	VBZ
cord-015021-pol2qm74	1270	3	not	not	RB
cord-015021-pol2qm74	1270	4	only	only	RB
cord-015021-pol2qm74	1270	5	involved	involve	VBN
cord-015021-pol2qm74	1270	6	in	in	IN
cord-015021-pol2qm74	1270	7	transendothelial	transendothelial	JJ
cord-015021-pol2qm74	1270	8	migration	migration	NN
cord-015021-pol2qm74	1270	9	,	,	,
cord-015021-pol2qm74	1270	10	but	but	CC
cord-015021-pol2qm74	1270	11	is	be	VBZ
cord-015021-pol2qm74	1270	12	also	also	RB
cord-015021-pol2qm74	1270	13	implicated	implicate	VBN
cord-015021-pol2qm74	1270	14	in	in	IN
cord-015021-pol2qm74	1270	15	adherencedependent	adherencedependent	NN
cord-015021-pol2qm74	1270	16	formation	formation	NN
cord-015021-pol2qm74	1270	17	of	of	IN
cord-015021-pol2qm74	1270	18	reactive	reactive	JJ
cord-015021-pol2qm74	1270	19	oxygen	oxygen	NN
cord-015021-pol2qm74	1270	20	species	specie	NNS
cord-015021-pol2qm74	1270	21	.	.	.
cord-015021-pol2qm74	1271	1	Blocking	block	VBG
cord-015021-pol2qm74	1271	2	CD1	CD1	NNP
cord-015021-pol2qm74	1272	1	lb	lb	CD
cord-015021-pol2qm74	1272	2	/	/	SYM
cord-015021-pol2qm74	1272	3	CD18	CD18	NNP
cord-015021-pol2qm74	1272	4	may	may	MD
cord-015021-pol2qm74	1272	5	therefore	therefore	RB
cord-015021-pol2qm74	1272	6	not	not	RB
cord-015021-pol2qm74	1272	7	only	only	RB
cord-015021-pol2qm74	1272	8	reduce	reduce	VB
cord-015021-pol2qm74	1272	9	the	the	DT
cord-015021-pol2qm74	1272	10	numbe	numbe	NN
cord-015021-pol2qm74	1272	11	r	r	NN
cord-015021-pol2qm74	1272	12	of	of	IN
cord-015021-pol2qm74	1272	13	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1272	14	accumulating	accumulate	VBG
cord-015021-pol2qm74	1272	15	in	in	IN
cord-015021-pol2qm74	1272	16	the	the	DT
cord-015021-pol2qm74	1272	17	tissue	tissue	NN
cord-015021-pol2qm74	1272	18	,	,	,
cord-015021-pol2qm74	1272	19	but	but	CC
cord-015021-pol2qm74	1272	20	also	also	RB
cord-015021-pol2qm74	1272	21	attenuate	attenuate	VB
cord-015021-pol2qm74	1272	22	the	the	DT
cord-015021-pol2qm74	1272	23	oxidant	oxidant	JJ
cord-015021-pol2qm74	1272	24	stress	stress	NN
cord-015021-pol2qm74	1272	25	of	of	IN
cord-015021-pol2qm74	1272	26	infiltrated	infiltrate	VBN
cord-015021-pol2qm74	1272	27	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1272	28	.	.	.
cord-015021-pol2qm74	1273	1	Anti	anti	JJ
cord-015021-pol2qm74	1273	2	-	-	JJ
cord-015021-pol2qm74	1273	3	CD	CD	NNP
cord-015021-pol2qm74	1273	4	11	11	CD
cord-015021-pol2qm74	1273	5	b	b	NN
cord-015021-pol2qm74	1273	6	treatment	treatment	NN
cord-015021-pol2qm74	1273	7	has	have	VBZ
cord-015021-pol2qm74	1273	8	been	be	VBN
cord-015021-pol2qm74	1273	9	used	use	VBN
cord-015021-pol2qm74	1273	10	effectively	effectively	RB
cord-015021-pol2qm74	1273	11	to	to	TO
cord-015021-pol2qm74	1273	12	reduce	reduce	VB
cord-015021-pol2qm74	1273	13	tissue	tissue	NN
cord-015021-pol2qm74	1273	14	injury	injury	NN
cord-015021-pol2qm74	1273	15	initiated	initiate	VBN
cord-015021-pol2qm74	1273	16	by	by	IN
cord-015021-pol2qm74	1273	17	ischemia	ischemia	NN
cord-015021-pol2qm74	1273	18	-	-	HYPH
cord-015021-pol2qm74	1273	19	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1273	20	,	,	,
cord-015021-pol2qm74	1273	21	complement	complement	NN
cord-015021-pol2qm74	1273	22	activation	activation	NN
cord-015021-pol2qm74	1273	23	and	and	CC
cord-015021-pol2qm74	1273	24	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	1273	25	.	.	.
cord-015021-pol2qm74	1274	1	Altering	alter	VBG
cord-015021-pol2qm74	1274	2	the	the	DT
cord-015021-pol2qm74	1274	3	host	host	NN
cord-015021-pol2qm74	1274	4	response	response	NN
cord-015021-pol2qm74	1274	5	by	by	IN
cord-015021-pol2qm74	1274	6	modulating	modulate	VBG
cord-015021-pol2qm74	1274	7	the	the	DT
cord-015021-pol2qm74	1274	8	function	function	NN
cord-015021-pol2qm74	1274	9	of	of	IN
cord-015021-pol2qm74	1274	10	adhesion	adhesion	NN
cord-015021-pol2qm74	1274	11	molecules	molecule	NNS
cord-015021-pol2qm74	1274	12	may	may	MD
cord-015021-pol2qm74	1274	13	attenuate	attenuate	VB
cord-015021-pol2qm74	1274	14	the	the	DT
cord-015021-pol2qm74	1274	15	inadvertent	inadvertent	JJ
cord-015021-pol2qm74	1274	16	injury	injury	NN
cord-015021-pol2qm74	1274	17	caused	cause	VBN
cord-015021-pol2qm74	1274	18	by	by	IN
cord-015021-pol2qm74	1274	19	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1274	20	,	,	,
cord-015021-pol2qm74	1274	21	but	but	CC
cord-015021-pol2qm74	1274	22	may	may	MD
cord-015021-pol2qm74	1274	23	also	also	RB
cord-015021-pol2qm74	1274	24	temporarily	temporarily	RB
cord-015021-pol2qm74	1274	25	leave	leave	VB
cord-015021-pol2qm74	1274	26	the	the	DT
cord-015021-pol2qm74	1274	27	host	host	NN
cord-015021-pol2qm74	1274	28	without	without	IN
cord-015021-pol2qm74	1274	29	effective	effective	JJ
cord-015021-pol2qm74	1274	30	defense	defense	NN
cord-015021-pol2qm74	1274	31	machinery	machinery	NN
cord-015021-pol2qm74	1274	32	.	.	.
cord-015021-pol2qm74	1275	1	Overall	overall	RB
cord-015021-pol2qm74	1275	2	,	,	,
cord-015021-pol2qm74	1275	3	animal	animal	NN
cord-015021-pol2qm74	1275	4	studies	study	NNS
cord-015021-pol2qm74	1275	5	suggest	suggest	VBP
cord-015021-pol2qm74	1275	6	that	that	IN
cord-015021-pol2qm74	1275	7	it	-PRON-	PRP
cord-015021-pol2qm74	1275	8	may	may	MD
cord-015021-pol2qm74	1275	9	be	be	VB
cord-015021-pol2qm74	1275	10	safe	safe	JJ
cord-015021-pol2qm74	1275	11	to	to	TO
cord-015021-pol2qm74	1275	12	inhibit	inhibit	VB
cord-015021-pol2qm74	1275	13	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1275	14	adhesion	adhesion	NN
cord-015021-pol2qm74	1275	15	for	for	IN
cord-015021-pol2qm74	1275	16	a	a	DT
cord-015021-pol2qm74	1275	17	limited	limited	JJ
cord-015021-pol2qm74	1275	18	period	period	NN
cord-015021-pol2qm74	1275	19	of	of	IN
cord-015021-pol2qm74	1275	20	rime	rime	NN
cord-015021-pol2qm74	1275	21	.	.	.
cord-015021-pol2qm74	1276	1	These	these	DT
cord-015021-pol2qm74	1276	2	observations	observation	NNS
cord-015021-pol2qm74	1276	3	will	will	MD
cord-015021-pol2qm74	1276	4	have	have	VB
cord-015021-pol2qm74	1276	5	to	to	TO
cord-015021-pol2qm74	1276	6	be	be	VB
cord-015021-pol2qm74	1276	7	confirmed	confirm	VBN
cord-015021-pol2qm74	1276	8	in	in	IN
cord-015021-pol2qm74	1276	9	carefully	carefully	RB
cord-015021-pol2qm74	1276	10	designed	design	VBN
cord-015021-pol2qm74	1276	11	clinical	clinical	JJ
cord-015021-pol2qm74	1276	12	trials	trial	NNS
cord-015021-pol2qm74	1276	13	.	.	.
cord-015021-pol2qm74	1277	1	C	C	NNP
cord-015021-pol2qm74	1277	2	,	,	,
cord-015021-pol2qm74	1277	3	arbobydrams	arbobydram	NNS
cord-015021-pol2qm74	1277	4	are	be	VBP
cord-015021-pol2qm74	1277	5	ubiquizom	ubiquizom	JJ
cord-015021-pol2qm74	1277	6	constir	constir	NNP
cord-015021-pol2qm74	1278	1	~uts	~uts	NNP
cord-015021-pol2qm74	1278	2	of	of	IN
cord-015021-pol2qm74	1278	3	cell	cell	NN
cord-015021-pol2qm74	1278	4	sv.rfaees	sv.rfaee	NNS
cord-015021-pol2qm74	1278	5	,	,	,
cord-015021-pol2qm74	1278	6	and	and	CC
cord-015021-pol2qm74	1278	7	possess	possess	VBP
cord-015021-pol2qm74	1278	8	many	many	JJ
cord-015021-pol2qm74	1278	9	c	c	NN
cord-015021-pol2qm74	1278	10	~	~	NFP
cord-015021-pol2qm74	1278	11	xSsfies	xSsfies	NNP
cord-015021-pol2qm74	1279	1	ttm~	ttm~	CD
cord-015021-pol2qm74	1279	2	m~,e	m~,e	CD
cord-015021-pol2qm74	1279	3	~em	~em	XX
cord-015021-pol2qm74	1280	1	ide~.	ide~.	NNP
cord-015021-pol2qm74	1280	2	canaidates	canaidates	NNPS
cord-015021-pol2qm74	1280	3	for	for	IN
cord-015021-pol2qm74	1280	4	r	r	NNP
cord-015021-pol2qm74	1280	5	~	~	CD
cord-015021-pol2qm74	1280	6	ognifioa	ognifioa	NNP
cord-015021-pol2qm74	1280	7	mole	mole	NN
cord-015021-pol2qm74	1280	8	~	~	NFP
cord-015021-pol2qm74	1280	9	ule	ule	NNP
cord-015021-pol2qm74	1280	10	&	&	CC
cord-015021-pol2qm74	1281	1	In	in	IN
cord-015021-pol2qm74	1281	2	m	m	NN
cord-015021-pol2qm74	1282	1	~y	~y	NNP
cord-015021-pol2qm74	1282	2	systems	system	NNS
cord-015021-pol2qm74	1282	3	whe,~	whe,~	POS
cord-015021-pol2qm74	1282	4	ceR	cer	JJ
cord-015021-pol2qm74	1282	5	udhesioa	udhesioa	NNS
cord-015021-pol2qm74	1283	1	~lays	~lay	NNS
cord-015021-pol2qm74	1284	1	a	a	DT
cord-015021-pol2qm74	1284	2	critical	critical	JJ
cord-015021-pol2qm74	1284	3	ro~	ro~	JJ
cord-015021-pol2qm74	1284	4	car	car	NN
cord-015021-pol2qm74	1284	5	~	~	NFP
cord-015021-pol2qm74	1284	6	hydram	hydram	NNP
cord-015021-pol2qm74	1285	1	l:~dtag	l:~dtag	NNP
cord-015021-pol2qm74	1285	2	~otegas	~otegas	NFP
cord-015021-pol2qm74	1285	3	have	have	VBP
cord-015021-pol2qm74	1285	4	been	be	VBN
cord-015021-pol2qm74	1285	5	shown	show	VBN
cord-015021-pol2qm74	1285	6	to	to	IN
cord-015021-pol2qm74	1285	7	b	b	NN
cord-015021-pol2qm74	1285	8	~	~	NFP
cord-015021-pol2qm74	1285	9	ad	ad	NN
cord-015021-pol2qm74	1285	10	tocell	tocell	NNP
cord-015021-pol2qm74	1285	11	surfa~	surfa~	NNP
cord-015021-pol2qm74	1285	12	earbohydzaxes	earbohydzaxes	NNP
cord-015021-pol2qm74	1286	1	~nd	~nd	NNP
cord-015021-pol2qm74	1287	1	pZrl	pZrl	NNP
cord-015021-pol2qm74	1287	2	~	~	NFP
cord-015021-pol2qm74	1287	3	pate	pate	NN
cord-015021-pol2qm74	1287	4	in	in	IN
cord-015021-pol2qm74	1287	5	cell	cell	NN
cord-015021-pol2qm74	1287	6	-	-	HYPH
cord-015021-pol2qm74	1287	7	ceil	ceil	NN
cord-015021-pol2qm74	1287	8	Lumtaefion	Lumtaefion	NNP
cord-015021-pol2qm74	1287	9	&	&	CC
cord-015021-pol2qm74	1287	10	Such	Such	NNP
cord-015021-pol2qm74	1287	11	sys,.ems	sys,.ems	NNPS
cord-015021-pol2qm74	1287	12	include	include	VBP
cord-015021-pol2qm74	1287	13	~rti	~rti	XX
cord-015021-pol2qm74	1288	1	~za	~za	NNP
cord-015021-pol2qm74	1288	2	~	~	NNP
cord-015021-pol2qm74	1288	3	io=	io=	NNP
cord-015021-pol2qm74	1288	4	,	,	,
cord-015021-pol2qm74	1288	5	deveaopmeat	deveaopmeat	NNP
cord-015021-pol2qm74	1288	6	,	,	,
cord-015021-pol2qm74	1288	7	l	l	NNP
cord-015021-pol2qm74	1288	8	~	~	NFP
cord-015021-pol2qm74	1288	9	thoge~-hcet	thoge~-hcet	NNP
cord-015021-pol2qm74	1288	10	reeog	reeog	NN
cord-015021-pol2qm74	1288	11	--	--	:
cord-015021-pol2qm74	1288	12	ition	ition	NN
cord-015021-pol2qm74	1289	1	~d	~d	.
cord-015021-pol2qm74	1290	1	i	i	PRP
cord-015021-pol2qm74	1290	2	~	~	CD
cord-015021-pol2qm74	1290	3	zmmadon	zmmadon	NNP
cord-015021-pol2qm74	1290	4	_	_	NNP
cord-015021-pol2qm74	1291	1	In	in	IN
cord-015021-pol2qm74	1291	2	particular	particular	JJ
cord-015021-pol2qm74	1291	3	,	,	,
cord-015021-pol2qm74	1291	4	tb.z	tb.z	VBD
cord-015021-pol2qm74	1291	5	recent	recent	JJ
cord-015021-pol2qm74	1291	6	di%~ve~	di%~ve~	NN
cord-015021-pol2qm74	1291	7	of	of	IN
cord-015021-pol2qm74	1291	8	Lhe	Lhe	NNP
cord-015021-pol2qm74	1291	9	selec~	selec~	NNP
cord-015021-pol2qm74	1291	10	and	and	CC
cord-015021-pol2qm74	1291	11	th~	th~	NNP
cord-015021-pol2qm74	1291	12	impo.~a	impo.~a	NNP
cord-015021-pol2qm74	1292	1	~C~	~C~	VBN
cord-015021-pol2qm74	1292	2	in	in	IN
cord-015021-pol2qm74	1292	3	teukccy~	teukccy~	NNP
cord-015021-pol2qm74	1293	1	udo	udo	NNP
cord-015021-pol2qm74	1293	2	~	~	NNP
cord-015021-pol2qm74	1293	3	lelium	lelium	NNP
cord-015021-pol2qm74	1293	4	adh	adh	NNP
cord-015021-pol2qm74	1294	1	~ion	~ion	NNP
cord-015021-pol2qm74	1294	2	has	have	VBZ
cord-015021-pol2qm74	1294	3	-~f	-~f	CD
cord-015021-pol2qm74	1295	1	~M	~M	NFP
cord-015021-pol2qm74	1295	2	av.c	av.c	NNS
cord-015021-pol2qm74	1295	3	~	~	NFP
cord-015021-pol2qm74	1295	4	on	on	IN
cord-015021-pol2qm74	1295	5	OK	OK	NNP
cord-015021-pol2qm74	1295	6	l~	l~	XX
cord-015021-pol2qm74	1296	1	in	in	IN
cord-015021-pol2qm74	1296	2	m	m	NNP
cord-015021-pol2qm74	1296	3	~	~	NNP
cord-015021-pol2qm74	1296	4	ted	ted	NNP
cord-015021-pol2qm74	1296	5	cell	cell	NN
cord-015021-pol2qm74	1296	6	adhe	adhe	NNP
cord-015021-pol2qm74	1296	7	~	~	NFP
cord-015021-pol2qm74	1296	8	on	on	RB
cord-015021-pol2qm74	1296	9	.	.	.
cord-015021-pol2qm74	1297	1	S	S	NNP
cord-015021-pol2qm74	1298	1	~vere	~vere	NNP
cord-015021-pol2qm74	1298	2	/	/	SYM
cord-015021-pol2qm74	1298	3	poten	poten	NNP
cord-015021-pol2qm74	1298	4	~	~	NNP
cord-015021-pol2qm74	1298	5	s	s	NN
cord-015021-pol2qm74	1298	6	/	/	SYM
cord-015021-pol2qm74	1298	7	cs.rbohydr~	cs.rbohydr~	NNP
cord-015021-pol2qm74	1299	1	l	l	NNP
cord-015021-pol2qm74	1299	2	~	~	NNP
cord-015021-pol2qm74	1299	3	ga	ga	NNP
cord-015021-pol2qm74	1299	4	~	~	NFP
cord-015021-pol2qm74	1299	5	S	S	NNP
cord-015021-pol2qm74	1299	6	hRve	hrve	ADD
cord-015021-pol2qm74	1300	1	~e	~e	NNP
cord-015021-pol2qm74	1301	1	~l	~l	NNP
cord-015021-pol2qm74	1301	2	~u	~u	NFP
cord-015021-pol2qm74	1301	3	~	~	NFP
cord-015021-pol2qm74	1301	4	ilied	ilie	VBN
cord-015021-pol2qm74	1301	5	for	for	IN
cord-015021-pol2qm74	1301	6	~he	~he	NNP
cord-015021-pol2qm74	1301	7	s	s	NNP
cord-015021-pol2qm74	1301	8	~	~	NFP
cord-015021-pol2qm74	1301	9	lcc	lcc	NNP
cord-015021-pol2qm74	1301	10	~	~	NNP
cord-015021-pol2qm74	1301	11	ins	ins	NNP
cord-015021-pol2qm74	1301	12	.	.	.
cord-015021-pol2qm74	1302	1	The,~	the,~	CD
cord-015021-pol2qm74	1302	2	c	c	NNP
cord-015021-pol2qm74	1303	1	~u	~u	NNP
cord-015021-pol2qm74	1303	2	be	be	VB
cord-015021-pol2qm74	1303	3	broadly	broadly	RB
cord-015021-pol2qm74	1303	4	di,,Sded	di,,sded	JJ
cord-015021-pol2qm74	1304	1	La	La	NNP
cord-015021-pol2qm74	1305	1	~o	~o	NFP
cord-015021-pol2qm74	1305	2	~Wo	~Wo	NFP
cord-015021-pol2qm74	1305	3	m'oups	m'oups	NNP
cord-015021-pol2qm74	1305	4	-sibyl	-sibyl	HYPH
cord-015021-pol2qm74	1305	5	L	L	NNP
cord-015021-pol2qm74	1306	1	~wis	~wis	NNP
cord-015021-pol2qm74	1306	2	x	x	SYM
cord-015021-pol2qm74	1306	3	m~	m~	XX
cord-015021-pol2qm74	1306	4	mh~.~l	mh~.~l	''
cord-015021-pol2qm74	1307	1	Oligo	Oligo	NNP
cord-015021-pol2qm74	1307	2	~	~	NFP
cord-015021-pol2qm74	1307	3	chadd	chadd	NNP
cord-015021-pol2qm74	1307	4	~	~	NFP
cord-015021-pol2qm74	1307	5	s	s	NNP
cord-015021-pol2qm74	1307	6	,	,	,
cord-015021-pol2qm74	1308	1	~d	~d	.
cord-015021-pol2qm74	1309	1	sf/~	sf/~	NNP
cord-015021-pol2qm74	1309	2	ca~	ca~	NNP
cord-015021-pol2qm74	1310	1	ohydmma	ohydmma	NNP
cord-015021-pol2qm74	1310	2	,	,	,
cord-015021-pol2qm74	1310	3	All	all	DT
cord-015021-pol2qm74	1310	4	~:~	~:~	CD
cord-015021-pol2qm74	1311	1	~l	~l	NNP
cord-015021-pol2qm74	1312	1	~dns	~dns	NNP
cord-015021-pol2qm74	1312	2	bind	bind	VB
cord-015021-pol2qm74	1312	3	m	m	NN
cord-015021-pol2qm74	1313	1	siflyl	siflyl	NNP
cord-015021-pol2qm74	1313	2	L	L	NNP
cord-015021-pol2qm74	1313	3	~	~	NNP
cord-015021-pol2qm74	1313	4	wis	wis	NNP
cord-015021-pol2qm74	1313	5	x	x	NNP
cord-015021-pol2qm74	1313	6	(	(	-LRB-
cord-015021-pol2qm74	1313	7	sie$	sie$	XX
cord-015021-pol2qm74	1313	8	o!igos	o!igos	NNP
cord-015021-pol2qm74	1313	9	~	~	NFP
cord-015021-pol2qm74	1313	10	ccb.e.rkMs	ccb.e.rkms	XX
cord-015021-pol2qm74	1313	11	,	,	,
cord-015021-pol2qm74	1313	12	zlthou~	zlthou~	NNP
cord-015021-pol2qm74	1313	13	w~	w~	NNP
cord-015021-pol2qm74	1313	14	differing	differ	VBG
cord-015021-pol2qm74	1313	15	avi~	avi~	CD
cord-015021-pol2qm74	1314	1	Re~.	re~.	LS
cord-015021-pol2qm74	1314	2	'	'	``
cord-015021-pol2qm74	1314	3	We	-PRON-	PRP
cord-015021-pol2qm74	1314	4	have	have	VBP
cord-015021-pol2qm74	1314	5	i~¢n	i~¢n	NNS
cord-015021-pol2qm74	1314	6	~	~	NFP
cord-015021-pol2qm74	1314	7	ed	ed	XX
cord-015021-pol2qm74	1314	8	the	the	DT
cord-015021-pol2qm74	1314	9	functional	functional	JJ
cord-015021-pol2qm74	1314	10	g	g	NNP
cord-015021-pol2qm74	1314	11	~	~	NFP
cord-015021-pol2qm74	1314	12	oups	oups	NNP
cord-015021-pol2qm74	1314	13	0a	0a	NNP
cord-015021-pol2qm74	1315	1	s	s	NNP
cord-015021-pol2qm74	1315	2	~	~	CD
cord-015021-pol2qm74	1315	3	ex	ex	NN
cord-015021-pol2qm74	1315	4	~n~	~n~	XX
cord-015021-pol2qm74	1316	1	med	med	NNP
cord-015021-pol2qm74	1316	2	/	/	SYM
cord-015021-pol2qm74	1316	3	a~	a~	:
cord-015021-pol2qm74	1316	4	~he	~he	NNP
cord-015021-pol2qm74	1317	1	b	b	LS
cord-015021-pol2qm74	1317	2	~	~	NFP
cord-015021-pol2qm74	1317	3	u	u	NNP
cord-015021-pol2qm74	1317	4	~di	~di	NNP
cord-015021-pol2qm74	1317	5	~	~	NFP
cord-015021-pol2qm74	1317	6	g	g	NN
cord-015021-pol2qm74	1317	7	of	of	IN
cord-015021-pol2qm74	1317	8	~h~	~h~	ADD
cord-015021-pol2qm74	1317	9	c	c	NN
cord-015021-pol2qm74	1317	10	~	~	NFP
cord-015021-pol2qm74	1317	11	b0hydmm	b0hydmm	NNP
cord-015021-pol2qm74	1317	12	=	=	SYM
cord-015021-pol2qm74	1317	13	E	e	NN
cord-015021-pol2qm74	1317	14	-	-	HYPH
cord-015021-pol2qm74	1317	15	Se	se	JJ
cord-015021-pol2qm74	1317	16	/	/	SYM
cord-015021-pol2qm74	1317	17	sedm	sedm	NNP
cord-015021-pol2qm74	1318	1	We	-PRON-	PRP
cord-015021-pol2qm74	1318	2	have	have	VBP
cord-015021-pol2qm74	1318	3	used	use	VBN
cord-015021-pol2qm74	1318	4	~hat	~hat	NNP
cord-015021-pol2qm74	1318	5	iv.formation	iv.formation	NNP
cord-015021-pol2qm74	1318	6	to	to	IN
cord-015021-pol2qm74	1318	7	sya	sya	NNP
cord-015021-pol2qm74	1318	8	~	~	NFP
cord-015021-pol2qm74	1318	9	esize	esize	NNP
cord-015021-pol2qm74	1318	10	sLe	sLe	NNP
cord-015021-pol2qm74	1318	11	~	~	NFP
cord-015021-pol2qm74	1318	12	'	'	''
cord-015021-pol2qm74	1318	13	~mt0gs	~mt0gs	NNP
cord-015021-pol2qm74	1318	14	r.he	r.he	NNP
cord-015021-pol2qm74	1318	15	,	,	,
cord-015021-pol2qm74	1318	16	t	t	NNP
cord-015021-pol2qm74	1318	17	focus	focus	NN
cord-015021-pol2qm74	1318	18	on	on	IN
cord-015021-pol2qm74	1318	19	replacing	replace	VBG
cord-015021-pol2qm74	1318	20	sLslic	sLslic	NNP
cord-015021-pol2qm74	1319	1	~Sd	~Sd	NFP
cord-015021-pol2qm74	1320	1	~nd	~nd	NNP
cord-015021-pol2qm74	1321	1	fuc0s¢	fuc0s¢	VBG
cord-015021-pol2qm74	1321	2	wi~	wi~	RB
cord-015021-pol2qm74	1321	3	simpler	simple	JJR
cord-015021-pol2qm74	1321	4	,	,	,
cord-015021-pol2qm74	1321	5	more	more	RBR
cord-015021-pol2qm74	1321	6	stable	stable	JJ
cord-015021-pol2qm74	1321	7	strunt	strunt	NN
cord-015021-pol2qm74	1321	8	~	~	NFP
cord-015021-pol2qm74	1321	9	es	es	XX
cord-015021-pol2qm74	1321	10	.	.	.
cord-015021-pol2qm74	1322	1	A[~ou	A[~ou	NNP
cord-015021-pol2qm74	1323	1	~a	~a	NNS
cord-015021-pol2qm74	1323	2	~	~	NFP
cord-015021-pol2qm74	1323	3	proeer~	proeer~	NN
cord-015021-pol2qm74	1323	4	is	be	VBZ
cord-015021-pol2qm74	1323	5	ongoing	ongoing	JJ
cord-015021-pol2qm74	1323	6	,	,	,
cord-015021-pol2qm74	1323	7	we	-PRON-	PRP
cord-015021-pol2qm74	1323	8	hve	hve	VBP
cord-015021-pol2qm74	1323	9	been	be	VBN
cord-015021-pol2qm74	1324	1	~ucee,.~ful	~ucee,.~ful	NFP
cord-015021-pol2qm74	1325	1	a~	a~	:
cord-015021-pol2qm74	1326	1	rep	rep	NNP
cord-015021-pol2qm74	1326	2	~	~	NNP
cord-015021-pol2qm74	1326	3	aein8	aein8	NNP
cord-015021-pol2qm74	1327	1	t.ke	t.ke	NNP
cord-015021-pol2qm74	1328	1	si	si	NNP
cord-015021-pol2qm74	1328	2	~	~	NFP
cord-015021-pol2qm74	1328	3	ic	ic	NNP
cord-015021-pol2qm74	1328	4	a	a	NNP
cord-015021-pol2qm74	1328	5	~	~	NFP
cord-015021-pol2qm74	1328	6	id	id	NN
cord-015021-pol2qm74	1328	7	.	.	.
cord-015021-pol2qm74	1329	1	residue	residue	NNP
cord-015021-pol2qm74	1329	2	wi~	wi~	NN
cord-015021-pol2qm74	1329	3	std.fzte	std.fzte	NNP
cord-015021-pol2qm74	1329	4	.	.	.
cord-015021-pol2qm74	1330	1	~ce~	~ce~	NNP
cord-015021-pol2qm74	1331	1	or	or	CC
cord-015021-pol2qm74	1331	2	la	la	NNP
cord-015021-pol2qm74	1332	1	~c	~c	NFP
cord-015021-pol2qm74	1332	2	amd	amd	NNP
cord-015021-pol2qm74	1332	3	groupa	groupa	NNP
cord-015021-pol2qm74	1333	1	We	-PRON-	PRP
cord-015021-pol2qm74	1333	2	t'we	t'we	NNP
cord-015021-pol2qm74	1334	1	ex2aninad	ex2aninad	NNP
cord-015021-pol2qm74	1334	2	&	&	CC
cord-015021-pol2qm74	1334	3	e	e	NNP
cord-015021-pol2qm74	1334	4	ten	ten	CD
cord-015021-pol2qm74	1334	5	,	,	,
cord-015021-pol2qm74	1334	6	bunion	bunion	NN
cord-015021-pol2qm74	1334	7	of	of	IN
cord-015021-pol2qm74	1334	8	ezed~	ezed~	NNP
cord-015021-pol2qm74	1334	9	hydroxyl	hydroxyl	NN
cord-015021-pol2qm74	1334	10	group	group	NN
cord-015021-pol2qm74	1334	11	of	of	IN
cord-015021-pol2qm74	1334	12	the	the	DT
cord-015021-pol2qm74	1334	13	fizeose	fizeose	JJ
cord-015021-pol2qm74	1334	14	residue	residue	NN
cord-015021-pol2qm74	1334	15	~	~	NFP
cord-015021-pol2qm74	1335	1	billding	billding	NN
cord-015021-pol2qm74	1335	2	of	of	IN
cord-015021-pol2qm74	1335	3	E-	E-	NNP
cord-015021-pol2qm74	1335	4	,	,	,
cord-015021-pol2qm74	1335	5	L-~nd	l-~nd	NN
cord-015021-pol2qm74	1335	6	P	p	NN
cord-015021-pol2qm74	1335	7	-	-	,
cord-015021-pol2qm74	1335	8	SeleeS	selee	NNS
cord-015021-pol2qm74	1335	9	..	..	.
cord-015021-pol2qm74	1336	1	u.	u.	NNP
cord-015021-pol2qm74	1337	1	We	-PRON-	PRP
cord-015021-pol2qm74	1337	2	have	have	VBP
cord-015021-pol2qm74	1337	3	also	also	RB
cord-015021-pol2qm74	1337	4	found	find	VBN
cord-015021-pol2qm74	1337	5	m	m	NNP
cord-015021-pol2qm74	1337	6	~	~	CD
cord-015021-pol2qm74	1337	7	fi	fi	NN
cord-015021-pol2qm74	1337	8	~	~	NNP
cord-015021-pol2qm74	1337	9	fio~	fio~	CD
cord-015021-pol2qm74	1337	10	of	of	IN
cord-015021-pol2qm74	1337	11	the	the	DT
cord-015021-pol2qm74	1337	12	reducing	reduce	VBG
cord-015021-pol2qm74	1337	13	end	end	NN
cord-015021-pol2qm74	1338	1	~¢.cha'i~	~¢.cha'i~	NNP
cord-015021-pol2qm74	1339	1	~z	~z	NFP
cord-015021-pol2qm74	1339	2	increase	increase	VB
cord-015021-pol2qm74	1339	3	mtagovSst	mtagovsst	CD
cord-015021-pol2qm74	1339	4	activity	activity	NN
cord-015021-pol2qm74	1339	5	.	.	.
cord-015021-pol2qm74	1340	1	The	the	DT
cord-015021-pol2qm74	1340	2	,	,	,
cord-015021-pol2qm74	1340	3	M¢ond	m¢ond	NN
cord-015021-pol2qm74	1340	4	.	.	.
cord-015021-pol2qm74	1341	1	group	group	NN
cord-015021-pol2qm74	1341	2	of	of	IN
cord-015021-pol2qm74	1341	3	figs	fig	NNS
cord-015021-pol2qm74	1341	4	,	,	,
cord-015021-pol2qm74	1341	5	rids	rid	VBZ
cord-015021-pol2qm74	1341	6	a.	a.	NN
cord-015021-pol2qm74	1342	1	R	R	NNP
cord-015021-pol2qm74	1342	2	eontzin	eontzin	NNP
cord-015021-pol2qm74	1343	1	su	su	NNP
cord-015021-pol2qm74	1344	1	~a~	~a~	NFP
cord-015021-pol2qm74	1344	2	0u	0u	CD
cord-015021-pol2qm74	1345	1	a	a	DT
cord-015021-pol2qm74	1345	2	ea.rbohydr	ea.rbohydr	NN
cord-015021-pol2qm74	1345	3	~	~	NFP
cord-015021-pol2qm74	1345	4	t¢	t¢	NN
cord-015021-pol2qm74	1345	5	support	support	NN
cord-015021-pol2qm74	1345	6	,	,	,
cord-015021-pol2qm74	1345	7	,	,	,
cord-015021-pol2qm74	1345	8	und	und	RB
cord-015021-pol2qm74	1345	9	seem	seem	VB
cord-015021-pol2qm74	1345	10	to	to	IN
cord-015021-pol2qm74	1345	11	bi~.d	bi~.d	NNP
cord-015021-pol2qm74	1345	12	to	to	TO
cord-015021-pol2qm74	1345	13	t	t	VB
cord-015021-pol2qm74	1346	1	~e	~e	NFP
cord-015021-pol2qm74	1346	2	sele	sele	NNP
cord-015021-pol2qm74	1346	3	~	~	NFP
cord-015021-pol2qm74	1346	4	ti	ti	NNP
cord-015021-pol2qm74	1346	5	~	~	NNP
cord-015021-pol2qm74	1346	6	s	s	NNP
cord-015021-pol2qm74	1347	1	wi~	wi~	NNP
cord-015021-pol2qm74	1347	2	dLf	dLf	NNP
cord-015021-pol2qm74	1347	3	:	:	:
cord-015021-pol2qm74	1347	4	ferem	ferem	NNP
cord-015021-pol2qm74	1347	5	characteristics	characteristic	NNS
cord-015021-pol2qm74	1347	6	C0.an	C0.an	NNP
cord-015021-pol2qm74	1347	7	does	do	VBZ
cord-015021-pol2qm74	1347	8	sLe	sle	NN
cord-015021-pol2qm74	1347	9	:	:	:
cord-015021-pol2qm74	1347	10	,	,	,
cord-015021-pol2qm74	1347	11	S	s	NN
cord-015021-pol2qm74	1347	12	=	=	SYM
cord-015021-pol2qm74	1347	13	h	h	NN
cord-015021-pol2qm74	1347	14	compounds	compound	NNS
cord-015021-pol2qm74	1347	15	are	be	VBP
cord-015021-pol2qm74	1347	16	m2ogniz~	m2ogniz~	JJ
cord-015021-pol2qm74	1348	1	d	d	NNP
cord-015021-pol2qm74	1348	2	by	by	IN
cord-015021-pol2qm74	1348	3	L	L	NNP
cord-015021-pol2qm74	1348	4	-	-	HYPH
cord-015021-pol2qm74	1348	5	Selects	select	NNS
cord-015021-pol2qm74	1348	6	.	.	.
cord-015021-pol2qm74	1349	1	md	md	NNP
cord-015021-pol2qm74	1349	2	p	p	NNP
cord-015021-pol2qm74	1349	3	-	-	HYPH
cord-015021-pol2qm74	1349	4	Selectia	Selectia	NNP
cord-015021-pol2qm74	1349	5	,	,	,
cord-015021-pol2qm74	1349	6	bur	bur	NN
cord-015021-pol2qm74	1349	7	.	.	NNP
cord-015021-pol2qm74	1349	8	,	,	,
cord-015021-pol2qm74	1349	9	in	in	IN
cord-015021-pol2qm74	1349	10	genera/	genera/	NNP
cord-015021-pol2qm74	1349	11	,	,	,
cord-015021-pol2qm74	1349	12	not	not	RB
cord-015021-pol2qm74	1349	13	E	e	NN
cord-015021-pol2qm74	1349	14	,	,	,
cord-015021-pol2qm74	1349	15	Selecti~	Selecti~	.
cord-015021-pol2qm74	1349	16	These	these	DT
cord-015021-pol2qm74	1349	17	dam	dam	NN
cord-015021-pol2qm74	1349	18	may	may	NNP
cord-015021-pol2qm74	1349	19	mdicam	mdicam	NNP
cord-015021-pol2qm74	1350	1	r.hat	r.hat	DT
cord-015021-pol2qm74	1350	2	L	l	NN
cord-015021-pol2qm74	1350	3	-	-	:
cord-015021-pol2qm74	1350	4	and	and	CC
cord-015021-pol2qm74	1350	5	P	p	NN
cord-015021-pol2qm74	1350	6	-	-	HYPH
cord-015021-pol2qm74	1350	7	S~	S~	NNP
cord-015021-pol2qm74	1351	1	¢at~	¢at~	NNP
cord-015021-pol2qm74	1351	2	h	h	NNP
cord-015021-pol2qm74	1352	1	~d	~d	NFP
cord-015021-pol2qm74	1352	2	via	via	IN
cord-015021-pol2qm74	1352	3	o	o	NN
cord-015021-pol2qm74	1352	4	,	,	,
cord-015021-pol2qm74	1352	5	second	second	JJ
cord-015021-pol2qm74	1352	6	~te	~te	NNP
cord-015021-pol2qm74	1352	7	thaz	thaz	NNP
cord-015021-pol2qm74	1352	8	operates	operate	VBZ
cord-015021-pol2qm74	1352	9	Lu~.ead	Lu~.ead	NNP
cord-015021-pol2qm74	1352	10	of	of	IN
cord-015021-pol2qm74	1352	11	,	,	,
cord-015021-pol2qm74	1352	12	or	or	CC
cord-015021-pol2qm74	1352	13	in	in	IN
cord-015021-pol2qm74	1352	14	conjunction	conjunction	NN
cord-015021-pol2qm74	1352	15	with	with	IN
cord-015021-pol2qm74	1352	16	~tc	~tc	NNP
cord-015021-pol2qm74	1353	1	sLe	sLe	NNS
cord-015021-pol2qm74	1353	2	"	"	''
cord-015021-pol2qm74	1353	3	b	b	NN
cord-015021-pol2qm74	1353	4	~	~	NFP
cord-015021-pol2qm74	1353	5	ding	ding	NNP
cord-015021-pol2qm74	1353	6	~iite	~iite	NNP
cord-015021-pol2qm74	1353	7	.	.	.
cord-015021-pol2qm74	1354	1	Dam	Dam	NNP
cord-015021-pol2qm74	1354	2	rela~&~g	rela~&~g	NNP
cord-015021-pol2qm74	1354	3	to	to	IN
cord-015021-pol2qm74	1354	4	±e	±e	NNP
cord-015021-pol2qm74	1354	5	,	,	,
cord-015021-pol2qm74	1354	6	se	se	NNP
cord-015021-pol2qm74	1354	7	two	two	CD
cord-015021-pol2qm74	1354	8	types	type	NNS
cord-015021-pol2qm74	1354	9	of	of	IN
cord-015021-pol2qm74	1354	10	,	,	,
cord-015021-pol2qm74	1354	11	ml~	ml~	NNP
cord-015021-pol2qm74	1354	12	liga	liga	NNP
cord-015021-pol2qm74	1355	1	~ds	~ds	NNP
cord-015021-pol2qm74	1355	2	have	have	VBP
cord-015021-pol2qm74	1355	3	beam	beam	NN
cord-015021-pol2qm74	1355	4	t	t	NN
cord-015021-pol2qm74	1356	1	~ed	~ed	NNP
cord-015021-pol2qm74	1356	2	to	to	IN
cord-015021-pol2qm74	1356	3	desig~	desig~	NNP
cord-015021-pol2qm74	1356	4	potential	potential	JJ
cord-015021-pol2qm74	1356	5	the2~peutics	the2~peutic	NNS
cord-015021-pol2qm74	1356	6	for	for	IN
cord-015021-pol2qm74	1356	7	i	i	PRP
cord-015021-pol2qm74	1356	8	~	~	CD
cord-015021-pol2qm74	1356	9	fi	fi	NN
cord-015021-pol2qm74	1356	10	~	~	NFP
cord-015021-pol2qm74	1356	11	anmat0ry	anmat0ry	NNP
cord-015021-pol2qm74	1356	12	disease	disease	NN
cord-015021-pol2qm74	1356	13	.	.	.
cord-015021-pol2qm74	1357	1	Lr	Lr	NNP
cord-015021-pol2qm74	1357	2	:	:	:
cord-015021-pol2qm74	1357	3	rng	rng	NNP
cord-015021-pol2qm74	1357	4	maimaI	maimaI	NNP
cord-015021-pol2qm74	1357	5	models	model	NNS
cord-015021-pol2qm74	1357	6	of	of	IN
cord-015021-pol2qm74	1357	7	acute	acute	JJ
cord-015021-pol2qm74	1357	8	lung	lung	NN
cord-015021-pol2qm74	1357	9	Lu3ury	Lu3ury	NNP
cord-015021-pol2qm74	1357	10	we	-PRON-	PRP
cord-015021-pol2qm74	1357	11	can	can	MD
cord-015021-pol2qm74	1357	12	demo	demo	VB
cord-015021-pol2qm74	1357	13	~	~	NFP
cord-015021-pol2qm74	1357	14	trate	trate	NNP
cord-015021-pol2qm74	1357	15	that	that	DT
cord-015021-pol2qm74	1357	16	eompmmds	eompmmds	NNP
cord-015021-pol2qm74	1357	17	that	that	WDT
cord-015021-pol2qm74	1357	18	inhibit	inhibit	NNP
cord-015021-pol2qm74	1357	19	seleetiu	seleetiu	NNP
cord-015021-pol2qm74	1357	20	birding	birding	NN
cord-015021-pol2qm74	1358	1	~	~	NFP
cord-015021-pol2qm74	1358	2	~i~	~i~	NFP
cord-015021-pol2qm74	1359	1	o	o	UH
cord-015021-pol2qm74	1359	2	hzve	hzve	NNP
cord-015021-pol2qm74	1359	3	ber	ber	NNP
cord-015021-pol2qm74	1359	4	~	~	NFP
cord-015021-pol2qm74	1359	5	ficial	ficial	JJ
cord-015021-pol2qm74	1359	6	effects	effect	NNS
cord-015021-pol2qm74	1359	7	when	when	WRB
cord-015021-pol2qm74	1359	8	uc	uc	NNP
cord-015021-pol2qm74	1359	9	~	~	NNP
cord-015021-pol2qm74	1359	10	d	d	NNP
cord-015021-pol2qm74	1359	11	in	in	IN
cord-015021-pol2qm74	1359	12	rive	rive	NNP
cord-015021-pol2qm74	1359	13	.	.	.
cord-015021-pol2qm74	1360	1	Progressive	progressive	JJ
cord-015021-pol2qm74	1360	2	microvascular	microvascular	JJ
cord-015021-pol2qm74	1360	3	damage	damage	NN
cord-015021-pol2qm74	1360	4	in	in	IN
cord-015021-pol2qm74	1360	5	the	the	DT
cord-015021-pol2qm74	1360	6	tissue	tissue	NN
cord-015021-pol2qm74	1361	1	adjacent	adjacent	JJ
cord-015021-pol2qm74	1361	2	to	to	IN
cord-015021-pol2qm74	1361	3	a	a	DT
cord-015021-pol2qm74	1361	4	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	1361	5	burn	burn	NN
cord-015021-pol2qm74	1361	6	injury	injury	NN
cord-015021-pol2qm74	1361	7	results	result	NNS
cord-015021-pol2qm74	1361	8	in	in	IN
cord-015021-pol2qm74	1361	9	extension	extension	NN
cord-015021-pol2qm74	1361	10	of	of	IN
cord-015021-pol2qm74	1361	11	burn	burn	NN
cord-015021-pol2qm74	1361	12	size	size	NN
cord-015021-pol2qm74	1361	13	.	.	.
cord-015021-pol2qm74	1362	1	The	the	DT
cord-015021-pol2qm74	1362	2	role	role	NN
cord-015021-pol2qm74	1362	3	of	of	IN
cord-015021-pol2qm74	1362	4	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1362	5	in	in	IN
cord-015021-pol2qm74	1362	6	the	the	DT
cord-015021-pol2qm74	1362	7	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	1362	8	of	of	IN
cord-015021-pol2qm74	1362	9	microvascular	microvascular	JJ
cord-015021-pol2qm74	1362	10	injury	injury	NN
cord-015021-pol2qm74	1362	11	was	be	VBD
cord-015021-pol2qm74	1362	12	investigated	investigate	VBN
cord-015021-pol2qm74	1362	13	by	by	IN
cord-015021-pol2qm74	1362	14	inhibition	inhibition	NN
cord-015021-pol2qm74	1362	15	of	of	IN
cord-015021-pol2qm74	1362	16	their	-PRON-	PRP$
cord-015021-pol2qm74	1362	17	adherence	adherence	NN
cord-015021-pol2qm74	1362	18	to	to	IN
cord-015021-pol2qm74	1362	19	the	the	DT
cord-015021-pol2qm74	1362	20	microvascular	microvascular	JJ
cord-015021-pol2qm74	1362	21	endothelium	endothelium	NN
cord-015021-pol2qm74	1362	22	using	use	VBG
cord-015021-pol2qm74	1362	23	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1362	24	antibodies	antibody	NNS
cord-015021-pol2qm74	1362	25	directed	direct	VBN
cord-015021-pol2qm74	1362	26	to	to	IN
cord-015021-pol2qm74	1362	27	leukocyte	leukocyte	VB
cord-015021-pol2qm74	1362	28	CDI	CDI	NNP
cord-015021-pol2qm74	1362	29	8	8	CD
cord-015021-pol2qm74	1362	30	or	or	CC
cord-015021-pol2qm74	1362	31	its	-PRON-	PRP$
cord-015021-pol2qm74	1362	32	endothelial	endothelial	JJ
cord-015021-pol2qm74	1362	33	ligaud	ligaud	NN
cord-015021-pol2qm74	1362	34	,	,	,
cord-015021-pol2qm74	1362	35	intercellular	intercellular	JJ
cord-015021-pol2qm74	1362	36	adhesion	adhesion	NN
cord-015021-pol2qm74	1362	37	molecule-1	molecule-1	NN
cord-015021-pol2qm74	1363	1	(	(	-LRB-
cord-015021-pol2qm74	1363	2	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1363	3	,	,	,
cord-015021-pol2qm74	1363	4	CD54	CD54	NNP
cord-015021-pol2qm74	1363	5	)	)	-RRB-
cord-015021-pol2qm74	1363	6	.	.	.
cord-015021-pol2qm74	1364	1	A	a	DT
cord-015021-pol2qm74	1364	2	model	model	NN
cord-015021-pol2qm74	1364	3	of	of	IN
cord-015021-pol2qm74	1364	4	thermal	thermal	JJ
cord-015021-pol2qm74	1364	5	injury	injury	NN
cord-015021-pol2qm74	1364	6	was	be	VBD
cord-015021-pol2qm74	1364	7	developed	develop	VBN
cord-015021-pol2qm74	1364	8	using	use	VBG
cord-015021-pol2qm74	1364	9	New	New	NNP
cord-015021-pol2qm74	1364	10	Zealand	Zealand	NNP
cord-015021-pol2qm74	1364	11	White	white	JJ
cord-015021-pol2qm74	1364	12	rabbits	rabbit	NNS
cord-015021-pol2qm74	1364	13	.	.	.
cord-015021-pol2qm74	1365	1	Two	two	CD
cord-015021-pol2qm74	1365	2	sets	set	NNS
cord-015021-pol2qm74	1365	3	of	of	IN
cord-015021-pol2qm74	1365	4	three	three	CD
cord-015021-pol2qm74	1365	5	full	full	JJ
cord-015021-pol2qm74	1365	6	-	-	HYPH
cord-015021-pol2qm74	1365	7	thickness	thickness	NN
cord-015021-pol2qm74	1365	8	burns	burn	NNS
cord-015021-pol2qm74	1365	9	separated	separate	VBN
cord-015021-pol2qm74	1365	10	by	by	IN
cord-015021-pol2qm74	1365	11	two	two	CD
cord-015021-pol2qm74	1365	12	5	5	CD
cord-015021-pol2qm74	1365	13	x	x	SYM
cord-015021-pol2qm74	1365	14	30-mm	30-mm	CD
cord-015021-pol2qm74	1365	15	zones	zone	NNS
cord-015021-pol2qm74	1365	16	were	be	VBD
cord-015021-pol2qm74	1365	17	produced	produce	VBN
cord-015021-pol2qm74	1365	18	by	by	IN
cord-015021-pol2qm74	1365	19	applying	apply	VBG
cord-015021-pol2qm74	1365	20	brass	brass	NN
cord-015021-pol2qm74	1365	21	probes	probe	NNS
cord-015021-pol2qm74	1365	22	heated	heat	VBN
cord-015021-pol2qm74	1365	23	to	to	IN
cord-015021-pol2qm74	1365	24	100	100	CD
cord-015021-pol2qm74	1365	25	°	°	NN
cord-015021-pol2qm74	1365	26	C	c	NN
cord-015021-pol2qm74	1365	27	to	to	IN
cord-015021-pol2qm74	1365	28	the	the	DT
cord-015021-pol2qm74	1365	29	animals	animal	NNS
cord-015021-pol2qm74	1365	30	'	'	POS
cord-015021-pol2qm74	1365	31	backs	back	NNS
cord-015021-pol2qm74	1365	32	for	for	IN
cord-015021-pol2qm74	1365	33	30	30	CD
cord-015021-pol2qm74	1365	34	sec	sec	NNP
cord-015021-pol2qm74	1365	35	.	.	.
cord-015021-pol2qm74	1366	1	Cutaneous	cutaneous	JJ
cord-015021-pol2qm74	1366	2	blood	blood	NN
cord-015021-pol2qm74	1366	3	flow	flow	NN
cord-015021-pol2qm74	1366	4	determinations	determination	NNS
cord-015021-pol2qm74	1366	5	carried	carry	VBN
cord-015021-pol2qm74	1366	6	out	out	RP
cord-015021-pol2qm74	1366	7	with	with	IN
cord-015021-pol2qm74	1366	8	a	a	DT
cord-015021-pol2qm74	1366	9	laser	laser	NN
cord-015021-pol2qm74	1366	10	doppler	doppler	NN
cord-015021-pol2qm74	1366	11	blood	blood	NN
cord-015021-pol2qm74	1366	12	flowmeter	flowmeter	NN
cord-015021-pol2qm74	1366	13	were	be	VBD
cord-015021-pol2qm74	1366	14	obtained	obtain	VBN
cord-015021-pol2qm74	1366	15	for	for	IN
cord-015021-pol2qm74	1366	16	72	72	CD
cord-015021-pol2qm74	1366	17	hours	hour	NNS
cord-015021-pol2qm74	1366	18	.	.	.
cord-015021-pol2qm74	1367	1	There	there	EX
cord-015021-pol2qm74	1367	2	were	be	VBD
cord-015021-pol2qm74	1367	3	five	five	CD
cord-015021-pol2qm74	1367	4	experimental	experimental	JJ
cord-015021-pol2qm74	1367	5	groups	group	NNS
cord-015021-pol2qm74	1367	6	:	:	:
cord-015021-pol2qm74	1367	7	controls	control	NNS
cord-015021-pol2qm74	1367	8	given	give	VBN
cord-015021-pol2qm74	1367	9	saline	saline	NN
cord-015021-pol2qm74	1367	10	alone	alone	RB
cord-015021-pol2qm74	1367	11	;	;	:
cord-015021-pol2qm74	1367	12	animals	animal	NNS
cord-015021-pol2qm74	1367	13	given	give	VBN
cord-015021-pol2qm74	1367	14	monoelonal	monoelonal	JJ
cord-015021-pol2qm74	1367	15	antibody	antibody	NN
cord-015021-pol2qm74	1367	16	to	to	IN
cord-015021-pol2qm74	1367	17	the	the	DT
cord-015021-pol2qm74	1367	18	CD	CD	NNP
cord-015021-pol2qm74	1367	19	18	18	CD
cord-015021-pol2qm74	1367	20	R	r	NN
cord-015021-pol2qm74	1367	21	15.7	15.7	CD
cord-015021-pol2qm74	1367	22	prior	prior	RB
cord-015021-pol2qm74	1367	23	to	to	TO
cord-015021-pol2qm74	1367	24	burn	burn	VB
cord-015021-pol2qm74	1367	25	injury	injury	NN
cord-015021-pol2qm74	1367	26	(	(	-LRB-
cord-015021-pol2qm74	1367	27	pre	pre	JJ
cord-015021-pol2qm74	1367	28	-	-	JJ
cord-015021-pol2qm74	1367	29	R	R	NNP
cord-015021-pol2qm74	1367	30	15.7	15.7	CD
cord-015021-pol2qm74	1367	31	)	)	-RRB-
cord-015021-pol2qm74	1367	32	;	;	:
cord-015021-pol2qm74	1367	33	animals	animal	NNS
cord-015021-pol2qm74	1367	34	given	give	VBN
cord-015021-pol2qm74	1367	35	R	R	NNP
cord-015021-pol2qm74	1367	36	15.7	15.7	CD
cord-015021-pol2qm74	1367	37	30	30	CD
cord-015021-pol2qm74	1367	38	min	min	NN
cord-015021-pol2qm74	1367	39	after	after	IN
cord-015021-pol2qm74	1367	40	burn	burn	NN
cord-015021-pol2qm74	1367	41	injury	injury	NN
cord-015021-pol2qm74	1367	42	(	(	-LRB-
cord-015021-pol2qm74	1367	43	post	post	NN
cord-015021-pol2qm74	1367	44	-	-	JJ
cord-015021-pol2qm74	1367	45	R	r	JJ
cord-015021-pol2qm74	1367	46	15.7	15.7	CD
cord-015021-pol2qm74	1367	47	)	)	-RRB-
cord-015021-pol2qm74	1367	48	;	;	:
cord-015021-pol2qm74	1367	49	animals	animal	NNS
cord-015021-pol2qm74	1367	50	given	give	VBN
cord-015021-pol2qm74	1367	51	a	a	DT
cord-015021-pol2qm74	1367	52	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1367	53	antibody	antibody	NN
cord-015021-pol2qm74	1367	54	to	to	IN
cord-015021-pol2qm74	1367	55	ICAM	ICAM	NNP
cord-015021-pol2qm74	1367	56	-	-	HYPH
cord-015021-pol2qm74	1367	57	I	I	NNP
cord-015021-pol2qm74	1367	58	,	,	,
cord-015021-pol2qm74	1367	59	R	R	NNP
cord-015021-pol2qm74	1367	60	6.5	6.5	CD
cord-015021-pol2qm74	1367	61	prior	prior	RB
cord-015021-pol2qm74	1367	62	to	to	TO
cord-015021-pol2qm74	1367	63	burn	burn	VB
cord-015021-pol2qm74	1367	64	(	(	-LRB-
cord-015021-pol2qm74	1367	65	pre	pre	VB
cord-015021-pol2qm74	1367	66	-	-	JJ
cord-015021-pol2qm74	1367	67	R	R	NNP
cord-015021-pol2qm74	1367	68	6.5	6.5	CD
cord-015021-pol2qm74	1367	69	)	)	-RRB-
cord-015021-pol2qm74	1367	70	;	;	:
cord-015021-pol2qm74	1367	71	and	and	CC
cord-015021-pol2qm74	1367	72	animals	animal	NNS
cord-015021-pol2qm74	1367	73	given	give	VBN
cord-015021-pol2qm74	1367	74	the	the	DT
cord-015021-pol2qm74	1367	75	R	R	NNP
cord-015021-pol2qm74	1367	76	6.5	6.5	CD
cord-015021-pol2qm74	1367	77	30	30	CD
cord-015021-pol2qm74	1367	78	min	min	NN
cord-015021-pol2qm74	1367	79	postburn	postburn	NN
cord-015021-pol2qm74	1367	80	injury	injury	NN
cord-015021-pol2qm74	1367	81	(	(	-LRB-
cord-015021-pol2qm74	1367	82	post	post	NN
cord-015021-pol2qm74	1367	83	-	-	JJ
cord-015021-pol2qm74	1367	84	R	R	NNP
cord-015021-pol2qm74	1367	85	6.5	6.5	CD
cord-015021-pol2qm74	1367	86	)	)	-RRB-
cord-015021-pol2qm74	1367	87	.	.	.
cord-015021-pol2qm74	1368	1	Blood	blood	NN
cord-015021-pol2qm74	1368	2	flow	flow	NN
cord-015021-pol2qm74	1368	3	in	in	IN
cord-015021-pol2qm74	1368	4	the	the	DT
cord-015021-pol2qm74	1368	5	marginal	marginal	JJ
cord-015021-pol2qm74	1368	6	"	"	``
cord-015021-pol2qm74	1368	7	zone	zone	NN
cord-015021-pol2qm74	1368	8	of	of	IN
cord-015021-pol2qm74	1368	9	stasis	stasis	NN
cord-015021-pol2qm74	1368	10	"	"	''
cord-015021-pol2qm74	1368	11	between	between	IN
cord-015021-pol2qm74	1368	12	burn	burn	NN
cord-015021-pol2qm74	1368	13	contact	contact	NN
cord-015021-pol2qm74	1368	14	sites	site	NNS
cord-015021-pol2qm74	1368	15	was	be	VBD
cord-015021-pol2qm74	1368	16	significantly	significantly	RB
cord-015021-pol2qm74	1368	17	higher	high	JJR
cord-015021-pol2qm74	1368	18	in	in	IN
cord-015021-pol2qm74	1368	19	the	the	DT
cord-015021-pol2qm74	1368	20	antibody	antibody	NN
cord-015021-pol2qm74	1368	21	-	-	HYPH
cord-015021-pol2qm74	1368	22	treated	treat	VBN
cord-015021-pol2qm74	1368	23	animals	animal	NNS
cord-015021-pol2qm74	1368	24	.	.	.
cord-015021-pol2qm74	1369	1	Administration	administration	NN
cord-015021-pol2qm74	1369	2	of	of	IN
cord-015021-pol2qm74	1369	3	the	the	DT
cord-015021-pol2qm74	1369	4	antibodies	antibody	NNS
cord-015021-pol2qm74	1369	5	30	30	CD
cord-015021-pol2qm74	1369	6	min	min	NN
cord-015021-pol2qm74	1369	7	after	after	IN
cord-015021-pol2qm74	1369	8	injury	injury	NN
cord-015021-pol2qm74	1369	9	was	be	VBD
cord-015021-pol2qm74	1369	10	as	as	RB
cord-015021-pol2qm74	1369	11	effective	effective	JJ
cord-015021-pol2qm74	1369	12	as	as	IN
cord-015021-pol2qm74	1369	13	preburn	preburn	NNP
cord-015021-pol2qm74	1369	14	administration	administration	NN
cord-015021-pol2qm74	1369	15	in	in	IN
cord-015021-pol2qm74	1369	16	preserving	preserve	VBG
cord-015021-pol2qm74	1369	17	blood	blood	NN
cord-015021-pol2qm74	1369	18	flow	flow	NN
cord-015021-pol2qm74	1369	19	.	.	.
cord-015021-pol2qm74	1370	1	At	at	IN
cord-015021-pol2qm74	1370	2	72	72	CD
cord-015021-pol2qm74	1370	3	hr	hr	NN
cord-015021-pol2qm74	1370	4	post	post	NN
cord-015021-pol2qm74	1370	5	-	-	JJ
cord-015021-pol2qm74	1370	6	burn	burn	VB
cord-015021-pol2qm74	1371	1	all	all	DT
cord-015021-pol2qm74	1371	2	antibody	antibody	NN
cord-015021-pol2qm74	1371	3	-treated	-treate	VBD
cord-015021-pol2qm74	1371	4	animals	animal	NNS
cord-015021-pol2qm74	1371	5	had	have	VBD
cord-015021-pol2qm74	1371	6	blood	blood	NN
cord-015021-pol2qm74	1371	7	flow	flow	NN
cord-015021-pol2qm74	1371	8	in	in	IN
cord-015021-pol2qm74	1371	9	the	the	DT
cord-015021-pol2qm74	1371	10	areas	area	NNS
cord-015021-pol2qm74	1371	11	at	at	IN
cord-015021-pol2qm74	1371	12	risk	risk	NN
cord-015021-pol2qm74	1371	13	for	for	IN
cord-015021-pol2qm74	1371	14	progression	progression	NN
cord-015021-pol2qm74	1371	15	(	(	-LRB-
cord-015021-pol2qm74	1371	16	i.e.	i.e.	FW
cord-015021-pol2qm74	1371	17	,	,	,
cord-015021-pol2qm74	1371	18	the	the	DT
cord-015021-pol2qm74	1371	19	zone	zone	NN
cord-015021-pol2qm74	1371	20	of	of	IN
cord-015021-pol2qm74	1371	21	stasis	stasis	NN
cord-015021-pol2qm74	1371	22	)	)	-RRB-
cord-015021-pol2qm74	1371	23	at	at	IN
cord-015021-pol2qm74	1371	24	or	or	CC
cord-015021-pol2qm74	1371	25	above	above	IN
cord-015021-pol2qm74	1371	26	baseline	baseline	JJ
cord-015021-pol2qm74	1371	27	levels	level	NNS
cord-015021-pol2qm74	1371	28	while	while	IN
cord-015021-pol2qm74	1371	29	the	the	DT
cord-015021-pol2qm74	1371	30	control	control	NN
cord-015021-pol2qm74	1371	31	animals	animal	NNS
cord-015021-pol2qm74	1371	32	had	have	VBD
cord-015021-pol2qm74	1371	33	levels	level	NNS
cord-015021-pol2qm74	1371	34	equal	equal	JJ
cord-015021-pol2qm74	1371	35	to	to	IN
cord-015021-pol2qm74	1371	36	34.7	34.7	CD
cord-015021-pol2qm74	1371	37	_	_	NN
cord-015021-pol2qm74	1371	38	+	+	CC
cord-015021-pol2qm74	1372	1	12	12	CD
cord-015021-pol2qm74	1372	2	%	%	NN
cord-015021-pol2qm74	1372	3	of	of	IN
cord-015021-pol2qm74	1372	4	baseline	baseline	NN
cord-015021-pol2qm74	1372	5	(	(	-LRB-
cord-015021-pol2qm74	1372	6	P	p	NN
cord-015021-pol2qm74	1372	7	<	<	XX
cord-015021-pol2qm74	1372	8	0.05	0.05	CD
cord-015021-pol2qm74	1372	9	by	by	IN
cord-015021-pol2qm74	1372	10	analysis	analysis	NN
cord-015021-pol2qm74	1372	11	of	of	IN
cord-015021-pol2qm74	1372	12	variance	variance	NN
cord-015021-pol2qm74	1372	13	and	and	CC
cord-015021-pol2qm74	1372	14	Mann	Mann	NNP
cord-015021-pol2qm74	1372	15	-	-	HYPH
cord-015021-pol2qm74	1372	16	Whitney	Whitney	NNP
cord-015021-pol2qm74	1372	17	U	U	NNP
cord-015021-pol2qm74	1372	18	test	test	NN
cord-015021-pol2qm74	1372	19	)	)	-RRB-
cord-015021-pol2qm74	1372	20	.	.	.
cord-015021-pol2qm74	1373	1	These	these	DT
cord-015021-pol2qm74	1373	2	results	result	NNS
cord-015021-pol2qm74	1373	3	indicate	indicate	VBP
cord-015021-pol2qm74	1373	4	that	that	IN
cord-015021-pol2qm74	1373	5	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1373	6	play	play	VBP
cord-015021-pol2qm74	1373	7	an	an	DT
cord-015021-pol2qm74	1373	8	important	important	JJ
cord-015021-pol2qm74	1373	9	role	role	NN
cord-015021-pol2qm74	1373	10	in	in	IN
cord-015021-pol2qm74	1373	11	the	the	DT
cord-015021-pol2qm74	1373	12	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	1373	13	of	of	IN
cord-015021-pol2qm74	1373	14	burn	burn	NN
cord-015021-pol2qm74	1373	15	wound	wound	NN
cord-015021-pol2qm74	1373	16	progression	progression	NN
cord-015021-pol2qm74	1373	17	,	,	,
cord-015021-pol2qm74	1373	18	and	and	CC
cord-015021-pol2qm74	1373	19	that	that	IN
cord-015021-pol2qm74	1373	20	this	this	DT
cord-015021-pol2qm74	1373	21	progression	progression	NN
cord-015021-pol2qm74	1373	22	can	can	MD
cord-015021-pol2qm74	1373	23	be	be	VB
cord-015021-pol2qm74	1373	24	attenuated	attenuate	VBN
cord-015021-pol2qm74	1373	25	by	by	IN
cord-015021-pol2qm74	1373	26	moduIating	moduiate	VBG
cord-015021-pol2qm74	1373	27	adherence	adherence	NN
cord-015021-pol2qm74	1373	28	to	to	IN
cord-015021-pol2qm74	1373	29	endothelial	endothelial	JJ
cord-015021-pol2qm74	1373	30	cells	cell	NNS
cord-015021-pol2qm74	1373	31	.	.	.
cord-015021-pol2qm74	1374	1	A	a	DT
cord-015021-pol2qm74	1374	2	wealth	wealth	NN
cord-015021-pol2qm74	1374	3	of	of	IN
cord-015021-pol2qm74	1374	4	information	information	NN
cord-015021-pol2qm74	1374	5	now	now	RB
cord-015021-pol2qm74	1374	6	supports	support	VBZ
cord-015021-pol2qm74	1374	7	the	the	DT
cord-015021-pol2qm74	1374	8	hypothesis	hypothesis	NN
cord-015021-pol2qm74	1374	9	that	that	DT
cord-015021-pol2qm74	1374	10	inhibition	inhibition	NN
cord-015021-pol2qm74	1374	11	of	of	IN
cord-015021-pol2qm74	1374	12	cell	cell	NN
cord-015021-pol2qm74	1374	13	adhesive	adhesive	NN
cord-015021-pol2qm74	1374	14	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1374	15	will	will	MD
cord-015021-pol2qm74	1374	16	Nter	Nter	NNP
cord-015021-pol2qm74	1374	17	the	the	DT
cord-015021-pol2qm74	1374	18	course	course	NN
cord-015021-pol2qm74	1374	19	of	of	IN
cord-015021-pol2qm74	1374	20	immunologicand	immunologicand	JJ
cord-015021-pol2qm74	1374	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1374	22	processes	process	NNS
cord-015021-pol2qm74	1374	23	.	.	.
cord-015021-pol2qm74	1375	1	What	what	WP
cord-015021-pol2qm74	1375	2	remains	remain	VBZ
cord-015021-pol2qm74	1375	3	unclear	unclear	JJ
cord-015021-pol2qm74	1375	4	is	be	VBZ
cord-015021-pol2qm74	1375	5	whether	whether	IN
cord-015021-pol2qm74	1375	6	inhibition	inhibition	NN
cord-015021-pol2qm74	1375	7	of	of	IN
cord-015021-pol2qm74	1375	8	specific	specific	JJ
cord-015021-pol2qm74	1375	9	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1375	10	wfl	wfl	NNP
cord-015021-pol2qm74	1375	11	[	[	-LRB-
cord-015021-pol2qm74	1375	12	be	be	VB
cord-015021-pol2qm74	1375	13	of	of	IN
cord-015021-pol2qm74	1375	14	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1375	15	benefit	benefit	NN
cord-015021-pol2qm74	1375	16	in	in	IN
cord-015021-pol2qm74	1375	17	any	any	DT
cord-015021-pol2qm74	1375	18	specific	specific	JJ
cord-015021-pol2qm74	1375	19	human	human	JJ
cord-015021-pol2qm74	1375	20	disease	disease	NN
cord-015021-pol2qm74	1375	21	.	.	.
cord-015021-pol2qm74	1376	1	Current	current	JJ
cord-015021-pol2qm74	1376	2	data	datum	NNS
cord-015021-pol2qm74	1376	3	derived	derive	VBN
cord-015021-pol2qm74	1376	4	from	from	IN
cord-015021-pol2qm74	1376	5	animal	animal	NN
cord-015021-pol2qm74	1376	6	models	model	NNS
cord-015021-pol2qm74	1376	7	are	be	VBP
cord-015021-pol2qm74	1376	8	not	not	RB
cord-015021-pol2qm74	1376	9	inconsistent	inconsistent	JJ
cord-015021-pol2qm74	1376	10	with	with	IN
cord-015021-pol2qm74	1376	11	the	the	DT
cord-015021-pol2qm74	1376	12	hope	hope	NN
cord-015021-pol2qm74	1376	13	of	of	IN
cord-015021-pol2qm74	1376	14	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1376	15	benefit	benefit	NN
cord-015021-pol2qm74	1376	16	,	,	,
cord-015021-pol2qm74	1376	17	but	but	CC
cord-015021-pol2qm74	1376	18	techniques	technique	NNS
cord-015021-pol2qm74	1376	19	for	for	IN
cord-015021-pol2qm74	1376	20	inhibition	inhibition	NN
cord-015021-pol2qm74	1376	21	(	(	-LRB-
cord-015021-pol2qm74	1376	22	e.g.	e.g.	RB
cord-015021-pol2qm74	1376	23	,	,	,
cord-015021-pol2qm74	1376	24	antibodies	antibody	NNS
cord-015021-pol2qm74	1376	25	,	,	,
cord-015021-pol2qm74	1376	26	antisense	antisense	NN
cord-015021-pol2qm74	1376	27	oligonucleotides	oligonucleotide	NNS
cord-015021-pol2qm74	1376	28	,	,	,
cord-015021-pol2qm74	1376	29	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1376	30	peptides	peptide	NNS
cord-015021-pol2qm74	1376	31	,	,	,
cord-015021-pol2qm74	1376	32	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1376	33	carbohydrates	carbohydrate	NNS
cord-015021-pol2qm74	1376	34	,	,	,
cord-015021-pol2qm74	1376	35	smaII	smaii	JJ
cord-015021-pol2qm74	1376	36	synthetic	synthetic	JJ
cord-015021-pol2qm74	1376	37	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	1376	38	,	,	,
cord-015021-pol2qm74	1376	39	etc	etc	FW
cord-015021-pol2qm74	1376	40	)	)	-RRB-
cord-015021-pol2qm74	1376	41	,	,	,
cord-015021-pol2qm74	1376	42	tissue	tissue	NN
cord-015021-pol2qm74	1376	43	and	and	CC
cord-015021-pol2qm74	1376	44	species	species	NN
cord-015021-pol2qm74	1376	45	differences	difference	NNS
cord-015021-pol2qm74	1376	46	in	in	IN
cord-015021-pol2qm74	1376	47	the	the	DT
cord-015021-pol2qm74	1376	48	relative	relative	JJ
cord-015021-pol2qm74	1376	49	contributions	contribution	NNS
cord-015021-pol2qm74	1376	50	of	of	IN
cord-015021-pol2qm74	1376	51	adhesion	adhesion	NN
cord-015021-pol2qm74	1376	52	molecules	molecule	NNS
cord-015021-pol2qm74	1376	53	to	to	IN
cord-015021-pol2qm74	1376	54	the	the	DT
cord-015021-pol2qm74	1376	55	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1376	56	process	process	NN
cord-015021-pol2qm74	1376	57	,	,	,
cord-015021-pol2qm74	1376	58	and	and	CC
cord-015021-pol2qm74	1376	59	the	the	DT
cord-015021-pol2qm74	1376	60	casCade	casCade	NNP
cord-015021-pol2qm74	1376	61	model	model	NN
cord-015021-pol2qm74	1376	62	of	of	IN
cord-015021-pol2qm74	1376	63	adhesive	adhesive	JJ
cord-015021-pol2qm74	1376	64	interactions	interaction	NNS
cord-015021-pol2qm74	1376	65	are	be	VBP
cord-015021-pol2qm74	1376	66	all	all	DT
cord-015021-pol2qm74	1376	67	confounding	confound	VBG
cord-015021-pol2qm74	1376	68	issues	issue	NNS
cord-015021-pol2qm74	1376	69	,	,	,
cord-015021-pol2qm74	1376	70	making	make	VBG
cord-015021-pol2qm74	1376	71	predictions	prediction	NNS
cord-015021-pol2qm74	1376	72	of	of	IN
cord-015021-pol2qm74	1376	73	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1376	74	benefit	benefit	NN
cord-015021-pol2qm74	1376	75	in	in	IN
cord-015021-pol2qm74	1376	76	any	any	DT
cord-015021-pol2qm74	1376	77	specific	specific	JJ
cord-015021-pol2qm74	1376	78	human	human	JJ
cord-015021-pol2qm74	1376	79	disease	disease	NN
cord-015021-pol2qm74	1376	80	process	process	NN
cord-015021-pol2qm74	1376	81	very	very	RB
cord-015021-pol2qm74	1376	82	difficult	difficult	JJ
cord-015021-pol2qm74	1376	83	.	.	.
cord-015021-pol2qm74	1377	1	Additional	additional	JJ
cord-015021-pol2qm74	1377	2	concerns	concern	NNS
cord-015021-pol2qm74	1377	3	involve	involve	VBP
cord-015021-pol2qm74	1377	4	the	the	DT
cord-015021-pol2qm74	1377	5	potential	potential	JJ
cord-015021-pol2qm74	1377	6	roles	role	NNS
cord-015021-pol2qm74	1377	7	of	of	IN
cord-015021-pol2qm74	1377	8	adhesive	adhesive	JJ
cord-015021-pol2qm74	1377	9	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1377	10	in	in	IN
cord-015021-pol2qm74	1377	11	host	host	NN
cord-015021-pol2qm74	1377	12	resistance	resistance	NN
cord-015021-pol2qm74	1377	13	to	to	IN
cord-015021-pol2qm74	1377	14	infection	infection	NN
cord-015021-pol2qm74	1377	15	.	.	.
cord-015021-pol2qm74	1378	1	As	as	IN
cord-015021-pol2qm74	1378	2	human	human	JJ
cord-015021-pol2qm74	1378	3	therapeutictdals	therapeutictdal	NNS
cord-015021-pol2qm74	1378	4	are	be	VBP
cord-015021-pol2qm74	1378	5	initiated	initiate	VBN
cord-015021-pol2qm74	1378	6	,	,	,
cord-015021-pol2qm74	1378	7	more	more	RBR
cord-015021-pol2qm74	1378	8	exact	exact	JJ
cord-015021-pol2qm74	1378	9	information	information	NN
cord-015021-pol2qm74	1378	10	on	on	IN
cord-015021-pol2qm74	1378	11	the	the	DT
cord-015021-pol2qm74	1378	12	roles	role	NNS
cord-015021-pol2qm74	1378	13	qf	qf	NN
cord-015021-pol2qm74	1378	14	specific	specific	JJ
cord-015021-pol2qm74	1378	15	adhesion	adhesion	NN
cord-015021-pol2qm74	1378	16	molecules	molecule	NNS
cord-015021-pol2qm74	1378	17	in	in	IN
cord-015021-pol2qm74	1378	18	human	human	JJ
cord-015021-pol2qm74	1378	19	disease	disease	NN
cord-015021-pol2qm74	1378	20	should	should	MD
cord-015021-pol2qm74	1378	21	emerge	emerge	VB
cord-015021-pol2qm74	1378	22	.	.	.
cord-015021-pol2qm74	1379	1	Inhibition	inhibition	NN
cord-015021-pol2qm74	1379	2	of	of	IN
cord-015021-pol2qm74	1379	3	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1379	4	adherence	adherence	NN
cord-015021-pol2qm74	1379	5	to	to	IN
cord-015021-pol2qm74	1379	6	endothelial	endothelial	JJ
cord-015021-pol2qm74	1379	7	cells	cell	NNS
cord-015021-pol2qm74	1379	8	can	can	MD
cord-015021-pol2qm74	1379	9	represent	represent	VB
cord-015021-pol2qm74	1379	10	a	a	DT
cord-015021-pol2qm74	1379	11	novel	novel	JJ
cord-015021-pol2qm74	1379	12	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1379	13	approach	approach	NN
cord-015021-pol2qm74	1379	14	to	to	IN
cord-015021-pol2qm74	1379	15	septic	septic	JJ
cord-015021-pol2qm74	1379	16	shock	shock	NN
cord-015021-pol2qm74	1379	17	.	.	.
cord-015021-pol2qm74	1380	1	We	-PRON-	PRP
cord-015021-pol2qm74	1380	2	performed	perform	VBD
cord-015021-pol2qm74	1380	3	a	a	DT
cord-015021-pol2qm74	1380	4	pilot	pilot	NN
cord-015021-pol2qm74	1380	5	study	study	NN
cord-015021-pol2qm74	1380	6	to	to	TO
cord-015021-pol2qm74	1380	7	evaluate	evaluate	VB
cord-015021-pol2qm74	1380	8	the	the	DT
cord-015021-pol2qm74	1380	9	safety	safety	NN
cord-015021-pol2qm74	1380	10	and	and	CC
cord-015021-pol2qm74	1380	11	tolerability	tolerability	NN
cord-015021-pol2qm74	1380	12	to	to	IN
cord-015021-pol2qm74	1380	13	CY-1787	CY-1787	NNP
cord-015021-pol2qm74	1380	14	,	,	,
cord-015021-pol2qm74	1380	15	a	a	DT
cord-015021-pol2qm74	1380	16	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1380	17	antibody	antibody	NN
cord-015021-pol2qm74	1380	18	against	against	IN
cord-015021-pol2qm74	1380	19	human	human	JJ
cord-015021-pol2qm74	1380	20	E	E	NNP
cord-015021-pol2qm74	1380	21	-	-	NN
cord-015021-pol2qm74	1380	22	selectin	selectin	NNP
cord-015021-pol2qm74	1380	23	,	,	,
cord-015021-pol2qm74	1380	24	in	in	IN
cord-015021-pol2qm74	1380	25	patients	patient	NNS
cord-015021-pol2qm74	1380	26	with	with	IN
cord-015021-pol2qm74	1380	27	septic	septic	JJ
cord-015021-pol2qm74	1380	28	shock	shock	NN
cord-015021-pol2qm74	1380	29	.	.	.
cord-015021-pol2qm74	1381	1	Septic	septic	JJ
cord-015021-pol2qm74	1381	2	shock	shock	NN
cord-015021-pol2qm74	1381	3	was	be	VBD
cord-015021-pol2qm74	1381	4	defined	define	VBN
cord-015021-pol2qm74	1381	5	by	by	IN
cord-015021-pol2qm74	1381	6	clinical	clinical	JJ
cord-015021-pol2qm74	1381	7	signs	sign	NNS
cord-015021-pol2qm74	1381	8	of	of	IN
cord-015021-pol2qm74	1381	9	sepsis	sepsis	NN
cord-015021-pol2qm74	1381	10	,	,	,
cord-015021-pol2qm74	1381	11	a	a	DT
cord-015021-pol2qm74	1381	12	documented	document	VBN
cord-015021-pol2qm74	1381	13	source	source	NN
cord-015021-pol2qm74	1381	14	of	of	IN
cord-015021-pol2qm74	1381	15	infection	infection	NN
cord-015021-pol2qm74	1381	16	,	,	,
cord-015021-pol2qm74	1381	17	and	and	CC
cord-015021-pol2qm74	1381	18	fluid	fluid	JJ
cord-015021-pol2qm74	1381	19	-	-	HYPH
cord-015021-pol2qm74	1381	20	resistant	resistant	JJ
cord-015021-pol2qm74	1381	21	hypotension	hypotension	NN
cord-015021-pol2qm74	1381	22	requiring	require	VBG
cord-015021-pol2qm74	1381	23	the	the	DT
cord-015021-pol2qm74	1381	24	use	use	NN
cord-015021-pol2qm74	1381	25	of	of	IN
cord-015021-pol2qm74	1381	26	vasopressors	vasopressor	NNS
cord-015021-pol2qm74	1381	27	.	.	.
cord-015021-pol2qm74	1382	1	Eleven	eleven	CD
cord-015021-pol2qm74	1382	2	patients	patient	NNS
cord-015021-pol2qm74	1382	3	entered	enter	VBD
cord-015021-pol2qm74	1382	4	the	the	DT
cord-015021-pol2qm74	1382	5	study	study	NN
cord-015021-pol2qm74	1382	6	,	,	,
cord-015021-pol2qm74	1382	7	but	but	CC
cord-015021-pol2qm74	1382	8	2	2	CD
cord-015021-pol2qm74	1382	9	patients	patient	NNS
cord-015021-pol2qm74	1382	10	who	who	WP
cord-015021-pol2qm74	1382	11	died	die	VBD
cord-015021-pol2qm74	1382	12	during	during	IN
cord-015021-pol2qm74	1382	13	the	the	DT
cord-015021-pol2qm74	1382	14	first	first	JJ
cord-015021-pol2qm74	1382	15	24	24	CD
cord-015021-pol2qm74	1382	16	hours	hour	NNS
cord-015021-pol2qm74	1382	17	were	be	VBD
cord-015021-pol2qm74	1382	18	excluded	exclude	VBN
cord-015021-pol2qm74	1382	19	,	,	,
cord-015021-pol2qm74	1382	20	as	as	IN
cord-015021-pol2qm74	1382	21	this	this	DT
cord-015021-pol2qm74	1382	22	was	be	VBD
cord-015021-pol2qm74	1382	23	part	part	NN
cord-015021-pol2qm74	1382	24	of	of	IN
cord-015021-pol2qm74	1382	25	the	the	DT
cord-015021-pol2qm74	1382	26	protocol	protocol	NN
cord-015021-pol2qm74	1382	27	.	.	.
cord-015021-pol2qm74	1383	1	CY-1787	CY-1787	NNP
cord-015021-pol2qm74	1383	2	was	be	VBD
cord-015021-pol2qm74	1383	3	administered	administer	VBN
cord-015021-pol2qm74	1383	4	as	as	IN
cord-015021-pol2qm74	1383	5	a	a	DT
cord-015021-pol2qm74	1383	6	single	single	JJ
cord-015021-pol2qm74	1383	7	intravenous	intravenous	JJ
cord-015021-pol2qm74	1383	8	bolus	bolus	NN
cord-015021-pol2qm74	1383	9	of	of	IN
cord-015021-pol2qm74	1383	10	0.1	0.1	CD
cord-015021-pol2qm74	1383	11	mg	mg	NNP
cord-015021-pol2qm74	1383	12	/	/	SYM
cord-015021-pol2qm74	1383	13	kg	kg	NNP
cord-015021-pol2qm74	1383	14	(	(	-LRB-
cord-015021-pol2qm74	1383	15	N=3	N=3	NNP
cord-015021-pol2qm74	1383	16	)	)	-RRB-
cord-015021-pol2qm74	1383	17	,	,	,
cord-015021-pol2qm74	1383	18	0.33	0.33	CD
cord-015021-pol2qm74	1383	19	mg	mg	NNP
cord-015021-pol2qm74	1383	20	/	/	SYM
cord-015021-pol2qm74	1383	21	kg	kg	NNP
cord-015021-pol2qm74	1383	22	(	(	-LRB-
cord-015021-pol2qm74	1383	23	N=3	N=3	NNP
cord-015021-pol2qm74	1383	24	)	)	-RRB-
cord-015021-pol2qm74	1383	25	or	or	CC
cord-015021-pol2qm74	1384	1	i	i	PRP
cord-015021-pol2qm74	1385	1	mg	mg	NNP
cord-015021-pol2qm74	1385	2	/	/	SYM
cord-015021-pol2qm74	1385	3	kg	kg	NNP
cord-015021-pol2qm74	1386	1	(	(	-LRB-
cord-015021-pol2qm74	1386	2	N=3	N=3	NNP
cord-015021-pol2qm74	1386	3	)	)	-RRB-
cord-015021-pol2qm74	1386	4	mg	mg	NNP
cord-015021-pol2qm74	1386	5	/	/	SYM
cord-015021-pol2qm74	1386	6	kg	kg	NNP
cord-015021-pol2qm74	1386	7	.	.	.
cord-015021-pol2qm74	1387	1	The	the	DT
cord-015021-pol2qm74	1387	2	antibody	antibody	NN
cord-015021-pol2qm74	1387	3	was	be	VBD
cord-015021-pol2qm74	1387	4	well	well	RB
cord-015021-pol2qm74	1387	5	tolerated	tolerate	VBN
cord-015021-pol2qm74	1387	6	.	.	.
cord-015021-pol2qm74	1388	1	None	none	NN
cord-015021-pol2qm74	1388	2	of	of	IN
cord-015021-pol2qm74	1388	3	the	the	DT
cord-015021-pol2qm74	1388	4	9	9	CD
cord-015021-pol2qm74	1388	5	patients	patient	NNS
cord-015021-pol2qm74	1388	6	died	die	VBD
cord-015021-pol2qm74	1388	7	during	during	IN
cord-015021-pol2qm74	1388	8	the	the	DT
cord-015021-pol2qm74	1388	9	28	28	CD
cord-015021-pol2qm74	1388	10	day	day	NN
cord-015021-pol2qm74	1388	11	follow	follow	NN
cord-015021-pol2qm74	1388	12	-	-	HYPH
cord-015021-pol2qm74	1388	13	up	up	NN
cord-015021-pol2qm74	1388	14	period	period	NN
cord-015021-pol2qm74	1388	15	.	.	.
cord-015021-pol2qm74	1389	1	Organ	organ	NN
cord-015021-pol2qm74	1389	2	failure	failure	NN
cord-015021-pol2qm74	1389	3	was	be	VBD
cord-015021-pol2qm74	1389	4	assessed	assess	VBN
cord-015021-pol2qm74	1389	5	for	for	IN
cord-015021-pol2qm74	1389	6	5	5	CD
cord-015021-pol2qm74	1389	7	organs	organ	NNS
cord-015021-pol2qm74	1389	8	(	(	-LRB-
cord-015021-pol2qm74	1389	9	CNS	CNS	NNP
cord-015021-pol2qm74	1389	10	,	,	,
cord-015021-pol2qm74	1389	11	lungs	lung	NNS
cord-015021-pol2qm74	1389	12	,	,	,
cord-015021-pol2qm74	1389	13	liver	liver	NN
cord-015021-pol2qm74	1389	14	,	,	,
cord-015021-pol2qm74	1389	15	kidneys	kidney	NNS
cord-015021-pol2qm74	1389	16	and	and	CC
cord-015021-pol2qm74	1389	17	coagulation	coagulation	NN
cord-015021-pol2qm74	1389	18	)	)	-RRB-
cord-015021-pol2qm74	1389	19	.	.	.
cord-015021-pol2qm74	1390	1	The	the	DT
cord-015021-pol2qm74	1390	2	mean	mean	JJ
cord-015021-pol2qm74	1390	3	number	number	NN
cord-015021-pol2qm74	1390	4	of	of	IN
cord-015021-pol2qm74	1390	5	organs	organ	NNS
cord-015021-pol2qm74	1390	6	failing	fail	VBG
cord-015021-pol2qm74	1390	7	,	,	,
cord-015021-pol2qm74	1390	8	which	which	WDT
cord-015021-pol2qm74	1390	9	was	be	VBD
cord-015021-pol2qm74	1390	10	initially	initially	RB
cord-015021-pol2qm74	1390	11	2.7	2.7	CD
cord-015021-pol2qm74	1390	12	±	±	CD
cord-015021-pol2qm74	1390	13	1.2	1.2	CD
cord-015021-pol2qm74	1390	14	,	,	,
cord-015021-pol2qm74	1390	15	decreased	decrease	VBD
cord-015021-pol2qm74	1390	16	to	to	IN
cord-015021-pol2qm74	1390	17	0.2	0.2	CD
cord-015021-pol2qm74	1390	18	±	±	CD
cord-015021-pol2qm74	1390	19	0.4	0.4	CD
cord-015021-pol2qm74	1390	20	at	at	IN
cord-015021-pol2qm74	1390	21	the	the	DT
cord-015021-pol2qm74	1390	22	end	end	NN
cord-015021-pol2qm74	1390	23	of	of	IN
cord-015021-pol2qm74	1390	24	the	the	DT
cord-015021-pol2qm74	1390	25	study	study	NN
cord-015021-pol2qm74	1390	26	(	(	-LRB-
cord-015021-pol2qm74	1390	27	p	p	NN
cord-015021-pol2qm74	1390	28	<	<	XX
cord-015021-pol2qm74	1390	29	O.O01	o.o01	NN
cord-015021-pol2qm74	1390	30	)	)	-RRB-
cord-015021-pol2qm74	1390	31	.	.	.
cord-015021-pol2qm74	1391	1	These	these	DT
cord-015021-pol2qm74	1391	2	results	result	NNS
cord-015021-pol2qm74	1391	3	are	be	VBP
cord-015021-pol2qm74	1391	4	therefore	therefore	RB
cord-015021-pol2qm74	1391	5	encouraging	encouraging	JJ
cord-015021-pol2qm74	1391	6	.	.	.
cord-015021-pol2qm74	1392	1	Administration	administration	NN
cord-015021-pol2qm74	1392	2	of	of	IN
cord-015021-pol2qm74	1392	3	an	an	DT
cord-015021-pol2qm74	1392	4	antibody	antibody	NN
cord-015021-pol2qm74	1392	5	to	to	IN
cord-015021-pol2qm74	1392	6	E	E	NNP
cord-015021-pol2qm74	1392	7	-	-	NN
cord-015021-pol2qm74	1392	8	selectin	selectin	NNS
cord-015021-pol2qm74	1392	9	in	in	IN
cord-015021-pol2qm74	1392	10	patients	patient	NNS
cord-015021-pol2qm74	1392	11	with	with	IN
cord-015021-pol2qm74	1392	12	septic	septic	JJ
cord-015021-pol2qm74	1392	13	shock	shock	NN
cord-015021-pol2qm74	1392	14	requires	require	VBZ
cord-015021-pol2qm74	1392	15	further	further	JJ
cord-015021-pol2qm74	1392	16	study	study	NN
cord-015021-pol2qm74	1392	17	.	.	.
cord-015021-pol2qm74	1393	1	The	the	DT
cord-015021-pol2qm74	1393	2	importance	importance	NN
cord-015021-pol2qm74	1393	3	of	of	IN
cord-015021-pol2qm74	1393	4	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	1393	5	T	t	NN
cord-015021-pol2qm74	1393	6	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	1393	7	(	(	-LRB-
cord-015021-pol2qm74	1393	8	CTL	CTL	NNP
cord-015021-pol2qm74	1393	9	)	)	-RRB-
cord-015021-pol2qm74	1393	10	in	in	IN
cord-015021-pol2qm74	1393	11	the	the	DT
cord-015021-pol2qm74	1393	12	host	host	NN
cord-015021-pol2qm74	1393	13	defense	defense	NN
cord-015021-pol2qm74	1393	14	mechanism	mechanism	NN
cord-015021-pol2qm74	1393	15	against	against	IN
cord-015021-pol2qm74	1393	16	viral	viral	JJ
cord-015021-pol2qm74	1393	17	as	as	RB
cord-015021-pol2qm74	1393	18	well	well	RB
cord-015021-pol2qm74	1393	19	as	as	IN
cord-015021-pol2qm74	1393	20	parasitic	parasitic	JJ
cord-015021-pol2qm74	1393	21	and	and	CC
cord-015021-pol2qm74	1393	22	bacterial	bacterial	JJ
cord-015021-pol2qm74	1393	23	diseases	disease	NNS
cord-015021-pol2qm74	1393	24	is	be	VBZ
cord-015021-pol2qm74	1393	25	becoming	become	VBG
cord-015021-pol2qm74	1393	26	increasingly	increasingly	RB
cord-015021-pol2qm74	1393	27	appreciated	appreciate	VBN
cord-015021-pol2qm74	1393	28	.	.	.
cord-015021-pol2qm74	1394	1	The	the	DT
cord-015021-pol2qm74	1394	2	design	design	NN
cord-015021-pol2qm74	1394	3	of	of	IN
cord-015021-pol2qm74	1394	4	vaccines	vaccine	NNS
cord-015021-pol2qm74	1394	5	to	to	TO
cord-015021-pol2qm74	1394	6	generate	generate	VB
cord-015021-pol2qm74	1394	7	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	1394	8	T	t	NN
cord-015021-pol2qm74	1394	9	ceils	ceil	NNS
cord-015021-pol2qm74	1394	10	from	from	IN
cord-015021-pol2qm74	1394	11	nonviable	nonviable	JJ
cord-015021-pol2qm74	1394	12	or	or	CC
cord-015021-pol2qm74	1394	13	subunit	subunit	NN
cord-015021-pol2qm74	1394	14	constructs	construct	NNS
cord-015021-pol2qm74	1394	15	,	,	,
cord-015021-pol2qm74	1394	16	however	however	RB
cord-015021-pol2qm74	1394	17	,	,	,
cord-015021-pol2qm74	1394	18	poses	pose	VBZ
cord-015021-pol2qm74	1394	19	challenges	challenge	NNS
cord-015021-pol2qm74	1394	20	due	due	JJ
cord-015021-pol2qm74	1394	21	to	to	IN
cord-015021-pol2qm74	1394	22	the	the	DT
cord-015021-pol2qm74	1394	23	unique	unique	JJ
cord-015021-pol2qm74	1394	24	characteristics	characteristic	NNS
cord-015021-pol2qm74	1394	25	of	of	IN
cord-015021-pol2qm74	1394	26	antigen	antigen	NN
cord-015021-pol2qm74	1394	27	processing	processing	NN
cord-015021-pol2qm74	1394	28	and	and	CC
cord-015021-pol2qm74	1394	29	presentation	presentation	NN
cord-015021-pol2qm74	1394	30	by	by	IN
cord-015021-pol2qm74	1394	31	class	class	NN
cord-015021-pol2qm74	1395	1	I	-PRON-	PRP
cord-015021-pol2qm74	1395	2	major	major	JJ
cord-015021-pol2qm74	1395	3	histocompatibility	histocompatibility	NN
cord-015021-pol2qm74	1395	4	complex	complex	NN
cord-015021-pol2qm74	1395	5	(	(	-LRB-
cord-015021-pol2qm74	1395	6	MHC	MHC	NNP
cord-015021-pol2qm74	1395	7	)	)	-RRB-
cord-015021-pol2qm74	1395	8	molecules	molecule	NNS
cord-015021-pol2qm74	1395	9	.	.	.
cord-015021-pol2qm74	1396	1	Since	since	IN
cord-015021-pol2qm74	1396	2	the	the	DT
cord-015021-pol2qm74	1396	3	final	final	JJ
cord-015021-pol2qm74	1396	4	antigen	antigen	NN
cord-015021-pol2qm74	1396	5	recognized	recognize	VBN
cord-015021-pol2qm74	1396	6	by	by	IN
cord-015021-pol2qm74	1396	7	CTL	CTL	NNP
cord-015021-pol2qm74	1396	8	are	be	VBP
cord-015021-pol2qm74	1396	9	short	short	JJ
cord-015021-pol2qm74	1396	10	peptides	peptide	NNS
cord-015021-pol2qm74	1396	11	capable	capable	JJ
cord-015021-pol2qm74	1396	12	of	of	IN
cord-015021-pol2qm74	1396	13	high	high	JJ
cord-015021-pol2qm74	1396	14	affinity	affinity	NN
cord-015021-pol2qm74	1396	15	binding	bind	VBG
cord-015021-pol2qm74	1396	16	to	to	IN
cord-015021-pol2qm74	1396	17	class	class	NN
cord-015021-pol2qm74	1396	18	I	-PRON-	PRP
cord-015021-pol2qm74	1396	19	MHC	MHC	NNP
cord-015021-pol2qm74	1396	20	molecules	molecule	NNS
cord-015021-pol2qm74	1396	21	,	,	,
cord-015021-pol2qm74	1396	22	we	-PRON-	PRP
cord-015021-pol2qm74	1396	23	have	have	VBP
cord-015021-pol2qm74	1396	24	designed	design	VBN
cord-015021-pol2qm74	1396	25	strategies	strategy	NNS
cord-015021-pol2qm74	1396	26	:	:	:
cord-015021-pol2qm74	1396	27	a	a	LS
cord-015021-pol2qm74	1396	28	)	)	-RRB-
cord-015021-pol2qm74	1396	29	to	to	TO
cord-015021-pol2qm74	1396	30	define	define	VB
cord-015021-pol2qm74	1396	31	the	the	DT
cord-015021-pol2qm74	1396	32	structural	structural	JJ
cord-015021-pol2qm74	1396	33	characteristics	characteristic	NNS
cord-015021-pol2qm74	1396	34	of	of	IN
cord-015021-pol2qm74	1396	35	peptides	peptide	NNS
cord-015021-pol2qm74	1396	36	that	that	WDT
cord-015021-pol2qm74	1396	37	are	be	VBP
cord-015021-pol2qm74	1396	38	required	require	VBN
cord-015021-pol2qm74	1396	39	for	for	IN
cord-015021-pol2qm74	1396	40	their	-PRON-	PRP$
cord-015021-pol2qm74	1396	41	high	high	JJ
cord-015021-pol2qm74	1396	42	affinity	affinity	NN
cord-015021-pol2qm74	1396	43	binding	bind	VBG
cord-015021-pol2qm74	1396	44	to	to	IN
cord-015021-pol2qm74	1396	45	MHC	MHC	NNP
cord-015021-pol2qm74	1396	46	;	;	:
cord-015021-pol2qm74	1396	47	and	and	CC
cord-015021-pol2qm74	1396	48	b	b	LS
cord-015021-pol2qm74	1396	49	)	)	-RRB-
cord-015021-pol2qm74	1396	50	to	to	TO
cord-015021-pol2qm74	1396	51	formulate	formulate	VB
cord-015021-pol2qm74	1396	52	these	these	DT
cord-015021-pol2qm74	1396	53	peptides	peptide	NNS
cord-015021-pol2qm74	1396	54	into	into	IN
cord-015021-pol2qm74	1396	55	immunogenic	immunogenic	JJ
cord-015021-pol2qm74	1396	56	vaccines	vaccine	NNS
cord-015021-pol2qm74	1396	57	that	that	WDT
cord-015021-pol2qm74	1396	58	are	be	VBP
cord-015021-pol2qm74	1396	59	capable	capable	JJ
cord-015021-pol2qm74	1396	60	of	of	IN
cord-015021-pol2qm74	1396	61	generating	generate	VBG
cord-015021-pol2qm74	1396	62	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	1396	63	T	t	NN
cord-015021-pol2qm74	1396	64	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	1396	65	.	.	.
cord-015021-pol2qm74	1397	1	The	the	DT
cord-015021-pol2qm74	1397	2	strategy	strategy	NN
cord-015021-pol2qm74	1397	3	and	and	CC
cord-015021-pol2qm74	1397	4	results	result	VBZ
cord-015021-pol2qm74	1397	5	to	to	TO
cord-015021-pol2qm74	1397	6	accomplish	accomplish	VB
cord-015021-pol2qm74	1397	7	these	these	DT
cord-015021-pol2qm74	1397	8	two	two	CD
cord-015021-pol2qm74	1397	9	goals	goal	NNS
cord-015021-pol2qm74	1397	10	will	will	MD
cord-015021-pol2qm74	1397	11	be	be	VB
cord-015021-pol2qm74	1397	12	discussed	discuss	VBN
cord-015021-pol2qm74	1397	13	.	.	.
cord-015021-pol2qm74	1398	1	Amnon	Amnon	NNP
cord-015021-pol2qm74	1398	2	Altman	Altman	NNP
cord-015021-pol2qm74	1398	3	and	and	CC
cord-015021-pol2qm74	1398	4	Erich	Erich	NNP
cord-015021-pol2qm74	1398	5	Gulbins	Gulbins	NNP
cord-015021-pol2qm74	1398	6	Ras	Ras	NNP
cord-015021-pol2qm74	1398	7	proteins	protein	NNS
cord-015021-pol2qm74	1398	8	represent	represent	VBP
cord-015021-pol2qm74	1398	9	essential	essential	JJ
cord-015021-pol2qm74	1398	10	intermediates	intermediate	NNS
cord-015021-pol2qm74	1398	11	in	in	IN
cord-015021-pol2qm74	1398	12	receptor	receptor	NN
cord-015021-pol2qm74	1398	13	-	-	HYPH
cord-015021-pol2qm74	1398	14	mediated	mediate	VBN
cord-015021-pol2qm74	1398	15	growth	growth	NN
cord-015021-pol2qm74	1398	16	and	and	CC
cord-015021-pol2qm74	1398	17	differentiation	differentiation	NN
cord-015021-pol2qm74	1398	18	pathways	pathway	NNS
cord-015021-pol2qm74	1398	19	.	.	.
cord-015021-pol2qm74	1399	1	They	-PRON-	PRP
cord-015021-pol2qm74	1399	2	couple	couple	NN
cord-015021-pol2qm74	1399	3	signals	signal	NNS
cord-015021-pol2qm74	1399	4	initiated	initiate	VBN
cord-015021-pol2qm74	1399	5	by	by	IN
cord-015021-pol2qm74	1399	6	receptor	receptor	NN
cord-015021-pol2qm74	1399	7	or	or	CC
cord-015021-pol2qm74	1399	8	nonreceptor	nonreceptor	NN
cord-015021-pol2qm74	1399	9	protein	protein	NN
cord-015021-pol2qm74	1399	10	tyrosine	tyrosine	NN
cord-015021-pol2qm74	1399	11	kinases	kinase	NNS
cord-015021-pol2qm74	1399	12	(	(	-LRB-
cord-015021-pol2qm74	1399	13	PTKs	PTKs	NNP
cord-015021-pol2qm74	1399	14	)	)	-RRB-
cord-015021-pol2qm74	1399	15	at	at	IN
cord-015021-pol2qm74	1399	16	the	the	DT
cord-015021-pol2qm74	1399	17	cell	cell	NN
cord-015021-pol2qm74	1399	18	surface	surface	NN
cord-015021-pol2qm74	1399	19	to	to	IN
cord-015021-pol2qm74	1399	20	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	1399	21	targets	target	NNS
cord-015021-pol2qm74	1399	22	which	which	WDT
cord-015021-pol2qm74	1399	23	coordinate	coordinate	VBP
cord-015021-pol2qm74	1399	24	signal	signal	NN
cord-015021-pol2qm74	1399	25	transduciion	transduciion	NN
cord-015021-pol2qm74	1399	26	to	to	IN
cord-015021-pol2qm74	1399	27	the	the	DT
cord-015021-pol2qm74	1399	28	nucleus	nucleus	NN
cord-015021-pol2qm74	1399	29	.	.	.
cord-015021-pol2qm74	1400	1	Ras	Ras	NNP
cord-015021-pol2qm74	1400	2	also	also	RB
cord-015021-pol2qm74	1400	3	participates	participate	VBZ
cord-015021-pol2qm74	1400	4	in	in	IN
cord-015021-pol2qm74	1400	5	T	T	NNP
cord-015021-pol2qm74	1400	6	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	1400	7	activation	activation	NN
cord-015021-pol2qm74	1400	8	initiated	initiate	VBN
cord-015021-pol2qm74	1400	9	by	by	IN
cord-015021-pol2qm74	1400	10	the	the	DT
cord-015021-pol2qm74	1400	11	antigen	antigen	NN
cord-015021-pol2qm74	1400	12	-	-	HYPH
cord-015021-pol2qm74	1400	13	specific	specific	JJ
cord-015021-pol2qm74	1400	14	T	t	NN
cord-015021-pol2qm74	1400	15	cell	cell	NN
cord-015021-pol2qm74	1400	16	receptor	receptor	NN
cord-015021-pol2qm74	1400	17	(	(	-LRB-
cord-015021-pol2qm74	1400	18	TCR)/CD3	TCR)/CD3	NNP
cord-015021-pol2qm74	1400	19	complex	complex	NN
cord-015021-pol2qm74	1400	20	,	,	,
cord-015021-pol2qm74	1400	21	which	which	WDT
cord-015021-pol2qm74	1400	22	leads	lead	VBZ
cord-015021-pol2qm74	1400	23	to	to	IN
cord-015021-pol2qm74	1400	24	lymphokine	lymphokine	NN
cord-015021-pol2qm74	1400	25	production	production	NN
cord-015021-pol2qm74	1400	26	and	and	CC
cord-015021-pol2qm74	1400	27	proliferation	proliferation	NN
cord-015021-pol2qm74	1400	28	.	.	.
cord-015021-pol2qm74	1401	1	Receptor	receptor	NN
cord-015021-pol2qm74	1401	2	ligation	ligation	NN
cord-015021-pol2qm74	1401	3	causes	cause	VBZ
cord-015021-pol2qm74	1401	4	activation	activation	NN
cord-015021-pol2qm74	1401	5	of	of	IN
cord-015021-pol2qm74	1401	6	associated	associate	VBN
cord-015021-pol2qm74	1401	7	PTKs	PTKs	NNP
cord-015021-pol2qm74	1401	8	of	of	IN
cord-015021-pol2qm74	1401	9	the	the	DT
cord-015021-pol2qm74	1401	10	Src	Src	NNP
cord-015021-pol2qm74	1401	11	and	and	CC
cord-015021-pol2qm74	1401	12	Syk	Syk	NNP
cord-015021-pol2qm74	1401	13	families	family	NNS
cord-015021-pol2qm74	1401	14	as	as	IN
cord-015021-pol2qm74	1401	15	the	the	DT
cord-015021-pol2qm74	1401	16	earliest	early	JJS
cord-015021-pol2qm74	1401	17	identifiable	identifiable	JJ
cord-015021-pol2qm74	1401	18	event	event	NN
cord-015021-pol2qm74	1401	19	in	in	IN
cord-015021-pol2qm74	1401	20	this	this	DT
cord-015021-pol2qm74	1401	21	pathway	pathway	NN
cord-015021-pol2qm74	1401	22	.	.	.
cord-015021-pol2qm74	1402	1	The	the	DT
cord-015021-pol2qm74	1402	2	importance	importance	NN
cord-015021-pol2qm74	1402	3	of	of	IN
cord-015021-pol2qm74	1402	4	Ras	Ras	NNP
cord-015021-pol2qm74	1402	5	in	in	IN
cord-015021-pol2qm74	1402	6	T	T	NNP
cord-015021-pol2qm74	1402	7	cell	cell	NN
cord-015021-pol2qm74	1402	8	activation	activation	NN
cord-015021-pol2qm74	1402	9	is	be	VBZ
cord-015021-pol2qm74	1402	10	indicated	indicate	VBN
cord-015021-pol2qm74	1402	11	by	by	IN
cord-015021-pol2qm74	1402	12	the	the	DT
cord-015021-pol2qm74	1402	13	findings	finding	NNS
cord-015021-pol2qm74	1402	14	that	that	IN
cord-015021-pol2qm74	1402	15	an	an	DT
cord-015021-pol2qm74	1402	16	oncogenic	oncogenic	JJ
cord-015021-pol2qm74	1402	17	Ras	Ras	NNP
cord-015021-pol2qm74	1402	18	protein	protein	NN
cord-015021-pol2qm74	1402	19	activates	activate	VBZ
cord-015021-pol2qm74	1402	20	the	the	DT
cord-015021-pol2qm74	1402	21	interleukin-2	interleukin-2	NN
cord-015021-pol2qm74	1402	22	(	(	-LRB-
cord-015021-pol2qm74	1402	23	IL-2	IL-2	NNP
cord-015021-pol2qm74	1402	24	)	)	-RRB-
cord-015021-pol2qm74	1402	25	gene	gene	NN
cord-015021-pol2qm74	1402	26	promoter	promoter	NN
cord-015021-pol2qm74	1402	27	;	;	:
cord-015021-pol2qm74	1402	28	conversely	conversely	RB
cord-015021-pol2qm74	1402	29	,	,	,
cord-015021-pol2qm74	1402	30	a	a	DT
cord-015021-pol2qm74	1402	31	transdominant	transdominant	JJ
cord-015021-pol2qm74	1402	32	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1402	33	ras	ras	NNP
cord-015021-pol2qm74	1402	34	mutant	mutant	NN
cord-015021-pol2qm74	1402	35	inhibits	inhibit	VBZ
cord-015021-pol2qm74	1402	36	this	this	DT
cord-015021-pol2qm74	1402	37	event	event	NN
cord-015021-pol2qm74	1402	38	and	and	CC
cord-015021-pol2qm74	1402	39	the	the	DT
cord-015021-pol2qm74	1402	40	activation	activation	NN
cord-015021-pol2qm74	1402	41	of	of	IN
cord-015021-pol2qm74	1402	42	MAP	MAP	NNP
cord-015021-pol2qm74	1402	43	kinases	kinase	NNS
cord-015021-pol2qm74	1402	44	.	.	.
cord-015021-pol2qm74	1403	1	The	the	DT
cord-015021-pol2qm74	1403	2	rate	rate	NN
cord-015021-pol2qm74	1403	3	-	-	HYPH
cord-015021-pol2qm74	1403	4	limiting	limit	VBG
cord-015021-pol2qm74	1403	5	step	step	NN
cord-015021-pol2qm74	1403	6	in	in	IN
cord-015021-pol2qm74	1403	7	Ras	Ras	NNP
cord-015021-pol2qm74	1403	8	activation	activation	NN
cord-015021-pol2qm74	1403	9	is	be	VBZ
cord-015021-pol2qm74	1403	10	the	the	DT
cord-015021-pol2qm74	1403	11	exchange	exchange	NN
cord-015021-pol2qm74	1403	12	of	of	IN
cord-015021-pol2qm74	1403	13	bound	bind	VBN
cord-015021-pol2qm74	1403	14	GDP	GDP	NNP
cord-015021-pol2qm74	1403	15	for	for	IN
cord-015021-pol2qm74	1403	16	GTP	GTP	NNP
cord-015021-pol2qm74	1403	17	,	,	,
cord-015021-pol2qm74	1403	18	which	which	WDT
cord-015021-pol2qm74	1403	19	is	be	VBZ
cord-015021-pol2qm74	1403	20	catalysed	catalyse	VBN
cord-015021-pol2qm74	1403	21	by	by	IN
cord-015021-pol2qm74	1403	22	guanine	guanine	NN
cord-015021-pol2qm74	1403	23	nucleotide	nucleotide	JJ
cord-015021-pol2qm74	1403	24	exchange	exchange	NN
cord-015021-pol2qm74	1403	25	factors	factor	NNS
cord-015021-pol2qm74	1403	26	(	(	-LRB-
cord-015021-pol2qm74	1403	27	GEFs	GEFs	NNP
cord-015021-pol2qm74	1403	28	)	)	-RRB-
cord-015021-pol2qm74	1403	29	.	.	.
cord-015021-pol2qm74	1404	1	We	-PRON-	PRP
cord-015021-pol2qm74	1404	2	identified	identify	VBD
cord-015021-pol2qm74	1404	3	the	the	DT
cord-015021-pol2qm74	1404	4	SH2	SH2	NNP
cord-015021-pol2qm74	1404	5	/	/	SYM
cord-015021-pol2qm74	1404	6	SH3	SH3	NNP
cord-015021-pol2qm74	1404	7	domain	domain	NN
cord-015021-pol2qm74	1404	8	-	-	HYPH
cord-015021-pol2qm74	1404	9	containing	contain	VBG
cord-015021-pol2qm74	1404	10	Vav	Vav	NNP
cord-015021-pol2qm74	1404	11	protein	protein	NN
cord-015021-pol2qm74	1404	12	,	,	,
cord-015021-pol2qm74	1404	13	which	which	WDT
cord-015021-pol2qm74	1404	14	is	be	VBZ
cord-015021-pol2qm74	1404	15	selectively	selectively	RB
cord-015021-pol2qm74	1404	16	expressed	express	VBN
cord-015021-pol2qm74	1404	17	in	in	IN
cord-015021-pol2qm74	1404	18	hematopoietic	hematopoietic	JJ
cord-015021-pol2qm74	1404	19	cells	cell	NNS
cord-015021-pol2qm74	1404	20	,	,	,
cord-015021-pol2qm74	1404	21	as	as	IN
cord-015021-pol2qm74	1404	22	a	a	DT
cord-015021-pol2qm74	1404	23	Ras	Ras	NNP
cord-015021-pol2qm74	1404	24	-	-	HYPH
cord-015021-pol2qm74	1404	25	specific	specific	JJ
cord-015021-pol2qm74	1404	26	GEF	GEF	NNP
cord-015021-pol2qm74	1404	27	coupled	couple	VBN
cord-015021-pol2qm74	1404	28	to	to	IN
cord-015021-pol2qm74	1404	29	several	several	JJ
cord-015021-pol2qm74	1404	30	hematopoietic	hematopoietic	JJ
cord-015021-pol2qm74	1404	31	receptors	receptor	NNS
cord-015021-pol2qm74	1404	32	.	.	.
cord-015021-pol2qm74	1405	1	Vav	Vav	NNP
cord-015021-pol2qm74	1405	2	can	can	MD
cord-015021-pol2qm74	1405	3	be	be	VB
cord-015021-pol2qm74	1405	4	activated	activate	VBN
cord-015021-pol2qm74	1405	5	by	by	IN
cord-015021-pol2qm74	1405	6	two	two	CD
cord-015021-pol2qm74	1405	7	pathways	pathway	NNS
cord-015021-pol2qm74	1405	8	,	,	,
cord-015021-pol2qm74	1405	9	i.e.	i.e.	FW
cord-015021-pol2qm74	1405	10	,	,	,
cord-015021-pol2qm74	1405	11	by	by	IN
cord-015021-pol2qm74	1405	12	PTK	PTK	NNP
cord-015021-pol2qm74	1405	13	-	-	HYPH
cord-015021-pol2qm74	1405	14	mediated	mediate	VBN
cord-015021-pol2qm74	1405	15	phosphorylation	phosphorylation	NN
cord-015021-pol2qm74	1405	16	or	or	CC
cord-015021-pol2qm74	1405	17	by	by	IN
cord-015021-pol2qm74	1405	18	binding	bind	VBG
cord-015021-pol2qm74	1405	19	of	of	IN
cord-015021-pol2qm74	1405	20	diglyceride	diglyceride	NN
cord-015021-pol2qm74	1405	21	second	second	JJ
cord-015021-pol2qm74	1405	22	messengers	messenger	NNS
cord-015021-pol2qm74	1405	23	to	to	IN
cord-015021-pol2qm74	1405	24	a	a	DT
cord-015021-pol2qm74	1405	25	cysteine	cysteine	NN
cord-015021-pol2qm74	1405	26	-	-	HYPH
cord-015021-pol2qm74	1405	27	rich	rich	JJ
cord-015021-pol2qm74	1405	28	,	,	,
cord-015021-pol2qm74	1405	29	protein	protein	NN
cord-015021-pol2qm74	1405	30	kinase	kinase	NN
cord-015021-pol2qm74	1405	31	C	c	NN
cord-015021-pol2qm74	1405	32	(	(	-LRB-
cord-015021-pol2qm74	1405	33	PKC)homologous	PKC)homologous	NNP
cord-015021-pol2qm74	1405	34	Vav	Vav	NNP
cord-015021-pol2qm74	1405	35	domain	domain	NN
cord-015021-pol2qm74	1405	36	.	.	.
cord-015021-pol2qm74	1406	1	These	these	DT
cord-015021-pol2qm74	1406	2	pathways	pathway	NNS
cord-015021-pol2qm74	1406	3	are	be	VBP
cord-015021-pol2qm74	1406	4	independent	independent	JJ
cord-015021-pol2qm74	1406	5	as	as	IN
cord-015021-pol2qm74	1406	6	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	1406	7	by	by	IN
cord-015021-pol2qm74	1406	8	structure	structure	NN
cord-015021-pol2qm74	1406	9	/	/	SYM
cord-015021-pol2qm74	1406	10	function	function	NN
cord-015021-pol2qm74	1406	11	analysis	analysis	NN
cord-015021-pol2qm74	1406	12	and	and	CC
cord-015021-pol2qm74	1406	13	the	the	DT
cord-015021-pol2qm74	1406	14	use	use	NN
cord-015021-pol2qm74	1406	15	of	of	IN
cord-015021-pol2qm74	1406	16	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	1406	17	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	1406	18	.	.	.
cord-015021-pol2qm74	1407	1	The	the	DT
cord-015021-pol2qm74	1407	2	two	two	CD
cord-015021-pol2qm74	1407	3	activation	activation	NN
cord-015021-pol2qm74	1407	4	pathways	pathway	NNS
cord-015021-pol2qm74	1407	5	may	may	MD
cord-015021-pol2qm74	1407	6	enable	enable	VB
cord-015021-pol2qm74	1407	7	Vav	Vav	NNP
cord-015021-pol2qm74	1407	8	to	to	TO
cord-015021-pol2qm74	1407	9	integrate	integrate	VB
cord-015021-pol2qm74	1407	10	signals	signal	NNS
cord-015021-pol2qm74	1407	11	from	from	IN
cord-015021-pol2qm74	1407	12	distinct	distinct	JJ
cord-015021-pol2qm74	1407	13	hematopoietic	hematopoietic	JJ
cord-015021-pol2qm74	1407	14	cell	cell	NN
cord-015021-pol2qm74	1407	15	receptors	receptor	NNS
cord-015021-pol2qm74	1407	16	,	,	,
cord-015021-pol2qm74	1407	17	and	and	CC
cord-015021-pol2qm74	1407	18	couple	couple	VB
cord-015021-pol2qm74	1407	19	them	-PRON-	PRP
cord-015021-pol2qm74	1407	20	to	to	IN
cord-015021-pol2qm74	1407	21	Ras	Ras	NNP
cord-015021-pol2qm74	1407	22	.	.	.
cord-015021-pol2qm74	1408	1	T	T	NNP
cord-015021-pol2qm74	1408	2	cells	cell	NNS
cord-015021-pol2qm74	1408	3	express	express	VBP
cord-015021-pol2qm74	1408	4	another	another	DT
cord-015021-pol2qm74	1408	5	,	,	,
cord-015021-pol2qm74	1408	6	ubiquitous	ubiquitous	JJ
cord-015021-pol2qm74	1408	7	Ras	Ras	NNP
cord-015021-pol2qm74	1408	8	GEF	GEF	NNP
cord-015021-pol2qm74	1408	9	,	,	,
cord-015021-pol2qm74	1408	10	i.e.	i.e.	FW
cord-015021-pol2qm74	1408	11	,	,	,
cord-015021-pol2qm74	1408	12	Sos	Sos	NNP
cord-015021-pol2qm74	1408	13	,	,	,
cord-015021-pol2qm74	1408	14	which	which	WDT
cord-015021-pol2qm74	1408	15	is	be	VBZ
cord-015021-pol2qm74	1408	16	known	know	VBN
cord-015021-pol2qm74	1408	17	to	to	TO
cord-015021-pol2qm74	1408	18	be	be	VB
cord-015021-pol2qm74	1408	19	coupled	couple	VBN
cord-015021-pol2qm74	1408	20	to	to	IN
cord-015021-pol2qm74	1408	21	activated	activate	VBN
cord-015021-pol2qm74	1408	22	TPK	TPK	NNP
cord-015021-pol2qm74	1408	23	receptors	receptor	NNS
cord-015021-pol2qm74	1408	24	.	.	.
cord-015021-pol2qm74	1409	1	T	T	NNP
cord-015021-pol2qm74	1409	2	cell	cell	NN
cord-015021-pol2qm74	1409	3	activation	activation	NN
cord-015021-pol2qm74	1409	4	leads	lead	VBZ
cord-015021-pol2qm74	1409	5	to	to	IN
cord-015021-pol2qm74	1409	6	membrane	membrane	NNP
cord-015021-pol2qm74	1409	7	association	association	NNP
cord-015021-pol2qm74	1409	8	of	of	IN
cord-015021-pol2qm74	1409	9	a	a	DT
cord-015021-pol2qm74	1409	10	signaling	signal	VBG
cord-015021-pol2qm74	1409	11	complex	complex	NN
cord-015021-pol2qm74	1409	12	consisting	consisting	NN
cord-015021-pol2qm74	1409	13	of	of	IN
cord-015021-pol2qm74	1409	14	Sos	Sos	NNP
cord-015021-pol2qm74	1409	15	and	and	CC
cord-015021-pol2qm74	1409	16	two	two	CD
cord-015021-pol2qm74	1409	17	other	other	JJ
cord-015021-pol2qm74	1409	18	signaling	signal	VBG
cord-015021-pol2qm74	1409	19	proteins	protein	NNS
cord-015021-pol2qm74	1409	20	,	,	,
cord-015021-pol2qm74	1409	21	Grb-2	Grb-2	NNP
cord-015021-pol2qm74	1409	22	and	and	CC
cord-015021-pol2qm74	1409	23	Shc	Shc	NNP
cord-015021-pol2qm74	1409	24	,	,	,
cord-015021-pol2qm74	1409	25	via	via	IN
cord-015021-pol2qm74	1409	26	direct	direct	JJ
cord-015021-pol2qm74	1409	27	binding	binding	NN
cord-015021-pol2qm74	1409	28	of	of	IN
cord-015021-pol2qm74	1409	29	the	the	DT
cord-015021-pol2qm74	1409	30	Shc	Shc	NNP
cord-015021-pol2qm74	1409	31	SH2	SH2	NNP
cord-015021-pol2qm74	1409	32	domain	domain	NN
cord-015021-pol2qm74	1409	33	to	to	IN
cord-015021-pol2qm74	1409	34	the	the	DT
cord-015021-pol2qm74	1409	35	tyrosine	tyrosine	NN
cord-015021-pol2qm74	1409	36	-	-	HYPH
cord-015021-pol2qm74	1409	37	phosphorylated	phosphorylate	VBN
cord-015021-pol2qm74	1409	38	chain	chain	NN
cord-015021-pol2qm74	1409	39	of	of	IN
cord-015021-pol2qm74	1409	40	the	the	DT
cord-015021-pol2qm74	1409	41	TCR	TCR	NNP
cord-015021-pol2qm74	1409	42	/	/	SYM
cord-015021-pol2qm74	1409	43	CD3	CD3	NNP
cord-015021-pol2qm74	1409	44	complex	complex	NN
cord-015021-pol2qm74	1409	45	.	.	.
cord-015021-pol2qm74	1410	1	Thus	thus	RB
cord-015021-pol2qm74	1410	2	,	,	,
cord-015021-pol2qm74	1410	3	multiple	multiple	JJ
cord-015021-pol2qm74	1410	4	receptors	receptor	NNS
cord-015021-pol2qm74	1410	5	,	,	,
cord-015021-pol2qm74	1410	6	PTKs	PTKs	NNP
cord-015021-pol2qm74	1410	7	and	and	CC
cord-015021-pol2qm74	1410	8	Ras	Ras	NNP
cord-015021-pol2qm74	1410	9	activators	activator	NNS
cord-015021-pol2qm74	1410	10	participate	participate	VBP
cord-015021-pol2qm74	1410	11	in	in	IN
cord-015021-pol2qm74	1410	12	signaling	signal	VBG
cord-015021-pol2qm74	1410	13	pathways	pathway	NNS
cord-015021-pol2qm74	1410	14	that	that	WDT
cord-015021-pol2qm74	1410	15	lead	lead	VBP
cord-015021-pol2qm74	1410	16	to	to	IN
cord-015021-pol2qm74	1410	17	hematopoieitc	hematopoieitc	NN
cord-015021-pol2qm74	1410	18	cell	cell	NN
cord-015021-pol2qm74	1410	19	growth	growth	NN
cord-015021-pol2qm74	1410	20	and	and	CC
cord-015021-pol2qm74	1410	21	differentiation	differentiation	NN
cord-015021-pol2qm74	1410	22	.	.	.
cord-015021-pol2qm74	1411	1	The	the	DT
cord-015021-pol2qm74	1411	2	interactions	interaction	NNS
cord-015021-pol2qm74	1411	3	and	and	CC
cord-015021-pol2qm74	1411	4	function	function	NN
cord-015021-pol2qm74	1411	5	of	of	IN
cord-015021-pol2qm74	1411	6	these	these	DT
cord-015021-pol2qm74	1411	7	various	various	JJ
cord-015021-pol2qm74	1411	8	signal	signal	NN
cord-015021-pol2qm74	1411	9	transducers	transducer	NNS
cord-015021-pol2qm74	1411	10	will	will	MD
cord-015021-pol2qm74	1411	11	be	be	VB
cord-015021-pol2qm74	1411	12	reviewed	review	VBN
cord-015021-pol2qm74	1411	13	.	.	.
cord-015021-pol2qm74	1412	1	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	1412	2	.	.	.
cord-015021-pol2qm74	1413	1	Immunity	immunity	NN
cord-015021-pol2qm74	1413	2	is	be	VBZ
cord-015021-pol2qm74	1413	3	mediated	mediate	VBN
cord-015021-pol2qm74	1413	4	by	by	IN
cord-015021-pol2qm74	1413	5	specific	specific	JJ
cord-015021-pol2qm74	1413	6	T	t	NN
cord-015021-pol2qm74	1413	7	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	1413	8	,	,	,
cord-015021-pol2qm74	1413	9	Cytokines	Cytokines	NNP
cord-015021-pol2qm74	1413	10	produced	produce	VBN
cord-015021-pol2qm74	1413	11	by	by	IN
cord-015021-pol2qm74	1413	12	these	these	DT
cord-015021-pol2qm74	1413	13	specific	specific	JJ
cord-015021-pol2qm74	1413	14	T	t	NN
cord-015021-pol2qm74	1413	15	cells	cell	NNS
cord-015021-pol2qm74	1413	16	activate	activate	VBP
cord-015021-pol2qm74	1413	17	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	1413	18	capacities	capacity	NNS
cord-015021-pol2qm74	1413	19	in	in	IN
cord-015021-pol2qm74	1413	20	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	1413	21	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	1413	22	,	,	,
cord-015021-pol2qm74	1413	23	thus	thus	RB
cord-015021-pol2qm74	1413	24	contributing	contribute	VBG
cord-015021-pol2qm74	1413	25	to	to	IN
cord-015021-pol2qm74	1413	26	protection	protection	NN
cord-015021-pol2qm74	1413	27	.	.	.
cord-015021-pol2qm74	1414	1	Other	other	JJ
cord-015021-pol2qm74	1414	2	immune	immune	JJ
cord-015021-pol2qm74	1414	3	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1414	4	also	also	RB
cord-015021-pol2qm74	1414	5	participate	participate	VBP
cord-015021-pol2qm74	1414	6	in	in	IN
cord-015021-pol2qm74	1414	7	the	the	DT
cord-015021-pol2qm74	1414	8	acquisition	acquisition	NN
cord-015021-pol2qm74	1414	9	of	of	IN
cord-015021-pol2qm74	1414	10	resistance	resistance	NN
cord-015021-pol2qm74	1414	11	.	.	.
cord-015021-pol2qm74	1415	1	On	on	IN
cord-015021-pol2qm74	1415	2	the	the	DT
cord-015021-pol2qm74	1415	3	other	other	JJ
cord-015021-pol2qm74	1415	4	hand	hand	NN
cord-015021-pol2qm74	1415	5	,	,	,
cord-015021-pol2qm74	1415	6	T	t	NN
cord-015021-pol2qm74	1415	7	cells	cell	NNS
cord-015021-pol2qm74	1415	8	are	be	VBP
cord-015021-pol2qm74	1415	9	also	also	RB
cord-015021-pol2qm74	1415	10	crucial	crucial	JJ
cord-015021-pol2qm74	1415	11	for	for	IN
cord-015021-pol2qm74	1415	12	many	many	JJ
cord-015021-pol2qm74	1415	13	pathologic	pathologic	JJ
cord-015021-pol2qm74	1415	14	sequelae	sequela	NNS
cord-015021-pol2qm74	1415	15	of	of	IN
cord-015021-pol2qm74	1415	16	intracellular	intracellular	JJ
cord-015021-pol2qm74	1415	17	bacterial	bacterial	JJ
cord-015021-pol2qm74	1415	18	infections	infection	NNS
cord-015021-pol2qm74	1415	19	.	.	.
cord-015021-pol2qm74	1416	1	Although	although	IN
cord-015021-pol2qm74	1416	2	IFN	IFN	NNP
cord-015021-pol2qm74	1416	3	-	-	HYPH
cord-015021-pol2qm74	1416	4	y	y	NNP
cord-015021-pol2qm74	1416	5	is	be	VBZ
cord-015021-pol2qm74	1416	6	central	central	JJ
cord-015021-pol2qm74	1416	7	to	to	IN
cord-015021-pol2qm74	1416	8	macrophage	macrophage	NN
cord-015021-pol2qm74	1416	9	activation	activation	NN
cord-015021-pol2qm74	1416	10	,	,	,
cord-015021-pol2qm74	1416	11	synergistic	synergistic	JJ
cord-015021-pol2qm74	1416	12	and	and	CC
cord-015021-pol2qm74	1416	13	antagonistic	antagonistic	JJ
cord-015021-pol2qm74	1416	14	effects	effect	NNS
cord-015021-pol2qm74	1416	15	with	with	IN
cord-015021-pol2qm74	1416	16	other	other	JJ
cord-015021-pol2qm74	1416	17	cytokines	cytokine	NNS
cord-015021-pol2qm74	1416	18	occur	occur	VBP
cord-015021-pol2qm74	1416	19	.	.	.
cord-015021-pol2qm74	1417	1	The	the	DT
cord-015021-pol2qm74	1417	2	cd/3	cd/3	NN
cord-015021-pol2qm74	1417	3	T	t	NN
cord-015021-pol2qm74	1417	4	cells	cell	NNS
cord-015021-pol2qm74	1417	5	,	,	,
cord-015021-pol2qm74	1417	6	representing	represent	VBG
cord-015021-pol2qm74	1417	7	the	the	DT
cord-015021-pol2qm74	1417	8	major	major	JJ
cord-015021-pol2qm74	1417	9	T	T	NNP
cord-015021-pol2qm74	1417	10	cell	cell	NN
cord-015021-pol2qm74	1417	11	population	population	NN
cord-015021-pol2qm74	1417	12	in	in	IN
cord-015021-pol2qm74	1417	13	experimental	experimental	JJ
cord-015021-pol2qm74	1417	14	mice	mouse	NNS
cord-015021-pol2qm74	1417	15	,	,	,
cord-015021-pol2qm74	1417	16	are	be	VBP
cord-015021-pol2qm74	1417	17	the	the	DT
cord-015021-pol2qm74	1417	18	main	main	JJ
cord-015021-pol2qm74	1417	19	mediators	mediator	NNS
cord-015021-pol2qm74	1417	20	of	of	IN
cord-015021-pol2qm74	1417	21	antibacterial	antibacterial	JJ
cord-015021-pol2qm74	1417	22	immunity	immunity	NN
cord-015021-pol2qm74	1417	23	;	;	:
cord-015021-pol2qm74	1417	24	an	an	DT
cord-015021-pol2qm74	1417	25	auxiliary	auxiliary	JJ
cord-015021-pol2qm74	1417	26	role	role	NN
cord-015021-pol2qm74	1417	27	for	for	IN
cord-015021-pol2qm74	1417	28	y/~	y/~	NNP
cord-015021-pol2qm74	1417	29	T	T	NNP
cord-015021-pol2qm74	1417	30	cells	cell	NNS
cord-015021-pol2qm74	1417	31	appears	appear	VBZ
cord-015021-pol2qm74	1417	32	likely	likely	JJ
cord-015021-pol2qm74	1417	33	.	.	.
cord-015021-pol2qm74	1418	1	The	the	DT
cord-015021-pol2qm74	1418	2	c~//3	c~//3	NNP
cord-015021-pol2qm74	1418	3	T	t	NN
cord-015021-pol2qm74	1418	4	cell	cell	NN
cord-015021-pol2qm74	1418	5	population	population	NN
cord-015021-pol2qm74	1418	6	further	further	RB
cord-015021-pol2qm74	1418	7	segregates	segregate	VBZ
cord-015021-pol2qm74	1418	8	into	into	IN
cord-015021-pol2qm74	1418	9	CD4	CD4	NNP
cord-015021-pol2qm74	1418	10	T	T	NNP
cord-015021-pol2qm74	1418	11	cells	cell	NNS
cord-015021-pol2qm74	1418	12	which	which	WDT
cord-015021-pol2qm74	1418	13	recognize	recognize	VBP
cord-015021-pol2qm74	1418	14	microbial	microbial	JJ
cord-015021-pol2qm74	1418	15	peptides	peptide	NNS
cord-015021-pol2qm74	1418	16	in	in	IN
cord-015021-pol2qm74	1418	17	the	the	DT
cord-015021-pol2qm74	1418	18	context	context	NN
cord-015021-pol2qm74	1418	19	of	of	IN
cord-015021-pol2qm74	1418	20	gene	gene	NN
cord-015021-pol2qm74	1418	21	products	product	NNS
cord-015021-pol2qm74	1418	22	of	of	IN
cord-015021-pol2qm74	1418	23	the	the	DT
cord-015021-pol2qm74	1418	24	major	major	JJ
cord-015021-pol2qm74	1418	25	histocompatibility	histocompatibility	NN
cord-015021-pol2qm74	1418	26	complex	complex	NN
cord-015021-pol2qm74	1418	27	(	(	-LRB-
cord-015021-pol2qm74	1418	28	MHC	MHC	NNP
cord-015021-pol2qm74	1418	29	)	)	-RRB-
cord-015021-pol2qm74	1418	30	and	and	CC
cord-015021-pol2qm74	1418	31	CD8	CD8	NNP
cord-015021-pol2qm74	1418	32	T	T	NNP
cord-015021-pol2qm74	1418	33	cells	cell	NNS
cord-015021-pol2qm74	1418	34	which	which	WDT
cord-015021-pol2qm74	1418	35	see	see	VBP
cord-015021-pol2qm74	1418	36	their	-PRON-	PRP$
cord-015021-pol2qm74	1418	37	peptide	peptide	NN
cord-015021-pol2qm74	1418	38	in	in	IN
cord-015021-pol2qm74	1418	39	the	the	DT
cord-015021-pol2qm74	1418	40	context	context	NN
cord-015021-pol2qm74	1418	41	of	of	IN
cord-015021-pol2qm74	1418	42	MHC	MHC	NNP
cord-015021-pol2qm74	1418	43	class	class	NN
cord-015021-pol2qm74	1418	44	I.	i.	NN
cord-015021-pol2qm74	1419	1	The	the	DT
cord-015021-pol2qm74	1419	2	-y/~	-y/~	NN
cord-015021-pol2qm74	1419	3	T	t	NN
cord-015021-pol2qm74	1419	4	cells	cell	NNS
cord-015021-pol2qm74	1419	5	are	be	VBP
cord-015021-pol2qm74	1419	6	generally	generally	RB
cord-015021-pol2qm74	1419	7	double	double	JJ
cord-015021-pol2qm74	1419	8	-	-	HYPH
cord-015021-pol2qm74	1419	9	negative	negative	JJ
cord-015021-pol2qm74	1419	10	.	.	.
cord-015021-pol2qm74	1420	1	Knock	knock	VB
cord-015021-pol2qm74	1420	2	-	-	HYPH
cord-015021-pol2qm74	1420	3	out	out	RP
cord-015021-pol2qm74	1420	4	mice	mouse	NNS
cord-015021-pol2qm74	1420	5	in	in	IN
cord-015021-pol2qm74	1420	6	which	which	WDT
cord-015021-pol2qm74	1420	7	the	the	DT
cord-015021-pol2qm74	1420	8	genes	gene	NNS
cord-015021-pol2qm74	1420	9	for	for	IN
cord-015021-pol2qm74	1420	10	various	various	JJ
cord-015021-pol2qm74	1420	11	T	t	NN
cord-015021-pol2qm74	1420	12	cell	cell	NN
cord-015021-pol2qm74	1420	13	receptor	receptor	NN
cord-015021-pol2qm74	1420	14	chains	chain	NNS
cord-015021-pol2qm74	1420	15	,	,	,
cord-015021-pol2qm74	1420	16	for	for	IN
cord-015021-pol2qm74	1420	17	MHC	MHC	NNP
cord-015021-pol2qm74	1420	18	class	class	NN
cord-015021-pol2qm74	1420	19	I	I	NNP
cord-015021-pol2qm74	1420	20	or	or	CC
cord-015021-pol2qm74	1420	21	MHC	MHC	NNP
cord-015021-pol2qm74	1420	22	class	class	NN
cord-015021-pol2qm74	1420	23	II	II	NNP
cord-015021-pol2qm74	1420	24	molecules	molecule	NNS
cord-015021-pol2qm74	1420	25	,	,	,
cord-015021-pol2qm74	1420	26	for	for	IN
cord-015021-pol2qm74	1420	27	cytokines	cytokine	NNS
cord-015021-pol2qm74	1420	28	or	or	CC
cord-015021-pol2qm74	1420	29	cytokine	cytokine	NN
cord-015021-pol2qm74	1420	30	receptors	receptor	NNS
cord-015021-pol2qm74	1420	31	had	have	VBD
cord-015021-pol2qm74	1420	32	been	be	VBN
cord-015021-pol2qm74	1420	33	deleted	delete	VBN
cord-015021-pol2qm74	1420	34	,	,	,
cord-015021-pol2qm74	1420	35	have	have	VBP
cord-015021-pol2qm74	1420	36	provided	provide	VBN
cord-015021-pol2qm74	1420	37	extremely	extremely	RB
cord-015021-pol2qm74	1420	38	helpful	helpful	JJ
cord-015021-pol2qm74	1420	39	tools	tool	NNS
cord-015021-pol2qm74	1420	40	for	for	IN
cord-015021-pol2qm74	1420	41	analyzing	analyze	VBG
cord-015021-pol2qm74	1420	42	the	the	DT
cord-015021-pol2qm74	1420	43	role	role	NN
cord-015021-pol2qm74	1420	44	of	of	IN
cord-015021-pol2qm74	1420	45	T	T	NNP
cord-015021-pol2qm74	1420	46	cell	cell	NN
cord-015021-pol2qm74	1420	47	subsets	subset	NNS
cord-015021-pol2qm74	1420	48	and	and	CC
cord-015021-pol2qm74	1420	49	cytokines	cytokine	NNS
cord-015021-pol2qm74	1420	50	in	in	IN
cord-015021-pol2qm74	1420	51	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	1420	52	immunity	immunity	NN
cord-015021-pol2qm74	1420	53	.	.	.
cord-015021-pol2qm74	1421	1	Using	use	VBG
cord-015021-pol2qm74	1421	2	these	these	DT
cord-015021-pol2qm74	1421	3	mutant	mutant	JJ
cord-015021-pol2qm74	1421	4	mice	mouse	NNS
cord-015021-pol2qm74	1421	5	,	,	,
cord-015021-pol2qm74	1421	6	the	the	DT
cord-015021-pol2qm74	1421	7	role	role	NN
cord-015021-pol2qm74	1421	8	of	of	IN
cord-015021-pol2qm74	1421	9	distinct	distinct	JJ
cord-015021-pol2qm74	1421	10	T	t	NN
cord-015021-pol2qm74	1421	11	cell	cell	NN
cord-015021-pol2qm74	1421	12	subsets	subset	NNS
cord-015021-pol2qm74	1421	13	and	and	CC
cord-015021-pol2qm74	1421	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	1421	15	in	in	IN
cord-015021-pol2qm74	1421	16	bacterial	bacterial	JJ
cord-015021-pol2qm74	1421	17	elimination	elimination	NN
cord-015021-pol2qm74	1421	18	and	and	CC
cord-015021-pol2qm74	1421	19	granuloma	granuloma	NN
cord-015021-pol2qm74	1421	20	formation	formation	NN
cord-015021-pol2qm74	1421	21	was	be	VBD
cord-015021-pol2qm74	1421	22	analyzed	analyze	VBN
cord-015021-pol2qm74	1421	23	in	in	IN
cord-015021-pol2qm74	1421	24	detail	detail	NN
cord-015021-pol2qm74	1421	25	.	.	.
cord-015021-pol2qm74	1422	1	These	these	DT
cord-015021-pol2qm74	1422	2	studies	study	NNS
cord-015021-pol2qm74	1422	3	underline	underline	VBP
cord-015021-pol2qm74	1422	4	the	the	DT
cord-015021-pol2qm74	1422	5	central	central	JJ
cord-015021-pol2qm74	1422	6	role	role	NN
cord-015021-pol2qm74	1422	7	of	of	IN
cord-015021-pol2qm74	1422	8	a//3	a//3	,
cord-015021-pol2qm74	1422	9	T	T	NNP
cord-015021-pol2qm74	1422	10	cells	cell	NNS
cord-015021-pol2qm74	1422	11	and	and	CC
cord-015021-pol2qm74	1422	12	IFN	IFN	NNP
cord-015021-pol2qm74	1422	13	-	-	HYPH
cord-015021-pol2qm74	1422	14	y	y	NNP
cord-015021-pol2qm74	1422	15	in	in	IN
cord-015021-pol2qm74	1422	16	antibacterial	antibacterial	JJ
cord-015021-pol2qm74	1422	17	immunity	immunity	NN
cord-015021-pol2qm74	1422	18	and	and	CC
cord-015021-pol2qm74	1422	19	,	,	,
cord-015021-pol2qm74	1422	20	furthermore	furthermore	RB
cord-015021-pol2qm74	1422	21	,	,	,
cord-015021-pol2qm74	1422	22	show	show	VBP
cord-015021-pol2qm74	1422	23	a	a	DT
cord-015021-pol2qm74	1422	24	distinct	distinct	JJ
cord-015021-pol2qm74	1422	25	function	function	NN
cord-015021-pol2qm74	1422	26	of	of	IN
cord-015021-pol2qm74	1422	27	7/$	7/$	NNS
cord-015021-pol2qm74	1422	28	T	T	NNP
cord-015021-pol2qm74	1422	29	cells	cell	NNS
cord-015021-pol2qm74	1422	30	.	.	.
cord-015021-pol2qm74	1423	1	Moreover	moreover	RB
cord-015021-pol2qm74	1423	2	,	,	,
cord-015021-pol2qm74	1423	3	these	these	DT
cord-015021-pol2qm74	1423	4	studies	study	NNS
cord-015021-pol2qm74	1423	5	show	show	VBP
cord-015021-pol2qm74	1423	6	that	that	IN
cord-015021-pol2qm74	1423	7	the	the	DT
cord-015021-pol2qm74	1423	8	relative	relative	JJ
cord-015021-pol2qm74	1423	9	contribution	contribution	NN
cord-015021-pol2qm74	1423	10	of	of	IN
cord-015021-pol2qm74	1423	11	CD8	CD8	NNP
cord-015021-pol2qm74	1423	12	or	or	CC
cord-015021-pol2qm74	1423	13	CD4	CD4	NNP
cord-015021-pol2qm74	1423	14	T	T	NNP
cord-015021-pol2qm74	1423	15	cells	cell	NNS
cord-015021-pol2qm74	1423	16	to	to	IN
cord-015021-pol2qm74	1423	17	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	1423	18	immunity	immunity	NN
cord-015021-pol2qm74	1423	19	varies	vary	VBZ
cord-015021-pol2qm74	1423	20	in	in	IN
cord-015021-pol2qm74	1423	21	response	response	NN
cord-015021-pol2qm74	1423	22	to	to	IN
cord-015021-pol2qm74	1423	23	different	different	JJ
cord-015021-pol2qm74	1423	24	pathogens	pathogen	NNS
cord-015021-pol2qm74	1423	25	.	.	.
cord-015021-pol2qm74	1424	1	Apoptosis	apoptosis	NN
cord-015021-pol2qm74	1424	2	is	be	VBZ
cord-015021-pol2qm74	1424	3	an	an	DT
cord-015021-pol2qm74	1424	4	active	active	JJ
cord-015021-pol2qm74	1424	5	form	form	NN
cord-015021-pol2qm74	1424	6	of	of	IN
cord-015021-pol2qm74	1424	7	cell	cell	NN
cord-015021-pol2qm74	1424	8	death	death	NN
cord-015021-pol2qm74	1424	9	in	in	IN
cord-015021-pol2qm74	1424	10	which	which	WDT
cord-015021-pol2qm74	1424	11	the	the	DT
cord-015021-pol2qm74	1424	12	cell	cell	NN
cord-015021-pol2qm74	1424	13	participates	participate	VBZ
cord-015021-pol2qm74	1424	14	in	in	IN
cord-015021-pol2qm74	1424	15	its	-PRON-	PRP$
cord-015021-pol2qm74	1424	16	own	own	JJ
cord-015021-pol2qm74	1424	17	demise	demise	NN
cord-015021-pol2qm74	1424	18	,	,	,
cord-015021-pol2qm74	1424	19	providing	provide	VBG
cord-015021-pol2qm74	1424	20	the	the	DT
cord-015021-pol2qm74	1424	21	biochemical	biochemical	JJ
cord-015021-pol2qm74	1424	22	pathways	pathway	NNS
cord-015021-pol2qm74	1424	23	that	that	WDT
cord-015021-pol2qm74	1424	24	trigger	trigger	VBP
cord-015021-pol2qm74	1424	25	and	and	CC
cord-015021-pol2qm74	1424	26	mediate	mediate	VB
cord-015021-pol2qm74	1424	27	the	the	DT
cord-015021-pol2qm74	1424	28	complex	complex	JJ
cord-015021-pol2qm74	1424	29	events	event	NNS
cord-015021-pol2qm74	1424	30	of	of	IN
cord-015021-pol2qm74	1424	31	the	the	DT
cord-015021-pol2qm74	1424	32	process	process	NN
cord-015021-pol2qm74	1424	33	.	.	.
cord-015021-pol2qm74	1425	1	Although	although	IN
cord-015021-pol2qm74	1425	2	this	this	DT
cord-015021-pol2qm74	1425	3	phenomenon	phenomenon	NN
cord-015021-pol2qm74	1425	4	has	have	VBZ
cord-015021-pol2qm74	1425	5	been	be	VBN
cord-015021-pol2qm74	1425	6	studied	study	VBN
cord-015021-pol2qm74	1425	7	for	for	IN
cord-015021-pol2qm74	1425	8	many	many	JJ
cord-015021-pol2qm74	1425	9	years	year	NNS
cord-015021-pol2qm74	1425	10	,	,	,
cord-015021-pol2qm74	1425	11	it	-PRON-	PRP
cord-015021-pol2qm74	1425	12	is	be	VBZ
cord-015021-pol2qm74	1425	13	only	only	RB
cord-015021-pol2qm74	1425	14	recently	recently	RB
cord-015021-pol2qm74	1425	15	that	that	IN
cord-015021-pol2qm74	1425	16	significant	significant	JJ
cord-015021-pol2qm74	1425	17	progress	progress	NN
cord-015021-pol2qm74	1425	18	has	have	VBZ
cord-015021-pol2qm74	1425	19	been	be	VBN
cord-015021-pol2qm74	1425	20	made	make	VBN
cord-015021-pol2qm74	1425	21	towards	towards	IN
cord-015021-pol2qm74	1425	22	the	the	DT
cord-015021-pol2qm74	1425	23	elucidation	elucidation	NN
cord-015021-pol2qm74	1425	24	of	of	IN
cord-015021-pol2qm74	1425	25	the	the	DT
cord-015021-pol2qm74	1425	26	molecular	molecular	JJ
cord-015021-pol2qm74	1425	27	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1425	28	that	that	WDT
cord-015021-pol2qm74	1425	29	control	control	VBP
cord-015021-pol2qm74	1425	30	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1425	31	.	.	.
cord-015021-pol2qm74	1426	1	Once	once	IN
cord-015021-pol2qm74	1426	2	such	such	JJ
cord-015021-pol2qm74	1426	3	mechanism	mechanism	NN
cord-015021-pol2qm74	1426	4	came	come	VBD
cord-015021-pol2qm74	1426	5	as	as	IN
cord-015021-pol2qm74	1426	6	something	something	NN
cord-015021-pol2qm74	1426	7	of	of	IN
cord-015021-pol2qm74	1426	8	a	a	DT
cord-015021-pol2qm74	1426	9	surprise	surprise	NN
cord-015021-pol2qm74	1426	10	:	:	:
cord-015021-pol2qm74	1426	11	in	in	IN
cord-015021-pol2qm74	1426	12	a	a	DT
cord-015021-pol2qm74	1426	13	number	number	NN
cord-015021-pol2qm74	1426	14	of	of	IN
cord-015021-pol2qm74	1426	15	eases	ease	NNS
cord-015021-pol2qm74	1426	16	,	,	,
cord-015021-pol2qm74	1426	17	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1426	18	can	can	MD
cord-015021-pol2qm74	1426	19	be	be	VB
cord-015021-pol2qm74	1426	20	promoted	promote	VBN
cord-015021-pol2qm74	1426	21	by	by	IN
cord-015021-pol2qm74	1426	22	the	the	DT
cord-015021-pol2qm74	1426	23	action	action	NN
cord-015021-pol2qm74	1426	24	of	of	IN
cord-015021-pol2qm74	1426	25	the	the	DT
cord-015021-pol2qm74	1426	26	c	c	NNP
cord-015021-pol2qm74	1426	27	-	-	HYPH
cord-015021-pol2qm74	1426	28	Myc	Myc	NNP
cord-015021-pol2qm74	1426	29	protein	protein	NN
cord-015021-pol2qm74	1426	30	,	,	,
cord-015021-pol2qm74	1426	31	a	a	DT
cord-015021-pol2qm74	1426	32	protooncogene	protooncogene	JJ
cord-015021-pol2qm74	1426	33	product	product	NN
cord-015021-pol2qm74	1426	34	that	that	WDT
cord-015021-pol2qm74	1426	35	had	have	VBD
cord-015021-pol2qm74	1426	36	previously	previously	RB
cord-015021-pol2qm74	1426	37	been	be	VBN
cord-015021-pol2qm74	1426	38	associated	associate	VBN
cord-015021-pol2qm74	1426	39	only	only	RB
cord-015021-pol2qm74	1426	40	with	with	IN
cord-015021-pol2qm74	1426	41	cell	cell	NN
cord-015021-pol2qm74	1426	42	proliferation	proliferation	NN
cord-015021-pol2qm74	1426	43	(	(	-LRB-
cord-015021-pol2qm74	1426	44	and	and	CC
cord-015021-pol2qm74	1426	45	presumably	presumably	RB
cord-015021-pol2qm74	1426	46	,	,	,
cord-015021-pol2qm74	1426	47	survival	survival	NN
cord-015021-pol2qm74	1426	48	)	)	-RRB-
cord-015021-pol2qm74	1426	49	.	.	.
cord-015021-pol2qm74	1427	1	Expression	expression	NN
cord-015021-pol2qm74	1427	2	of	of	IN
cord-015021-pol2qm74	1427	3	c.	c.	NN
cord-015021-pol2qm74	1428	1	Myc	Myc	NNP
cord-015021-pol2qm74	1428	2	in	in	IN
cord-015021-pol2qm74	1428	3	cells	cell	NNS
cord-015021-pol2qm74	1428	4	can	can	MD
cord-015021-pol2qm74	1428	5	cause	cause	VB
cord-015021-pol2qm74	1428	6	them	-PRON-	PRP
cord-015021-pol2qm74	1428	7	to	to	TO
cord-015021-pol2qm74	1428	8	enter	enter	VB
cord-015021-pol2qm74	1428	9	an	an	DT
cord-015021-pol2qm74	1428	10	apoptotic	apoptotic	JJ
cord-015021-pol2qm74	1428	11	pathway	pathway	NN
cord-015021-pol2qm74	1428	12	or	or	CC
cord-015021-pol2qm74	1428	13	proliferate	proliferate	VBP
cord-015021-pol2qm74	1428	14	,	,	,
cord-015021-pol2qm74	1428	15	mad	mad	JJ
cord-015021-pol2qm74	1428	16	this	this	DT
cord-015021-pol2qm74	1428	17	"	"	``
cord-015021-pol2qm74	1428	18	decision	decision	NN
cord-015021-pol2qm74	1428	19	"	"	''
cord-015021-pol2qm74	1428	20	depends	depend	VBZ
cord-015021-pol2qm74	1428	21	upon	upon	IN
cord-015021-pol2qm74	1428	22	additional	additional	JJ
cord-015021-pol2qm74	1428	23	signals	signal	NNS
cord-015021-pol2qm74	1428	24	,	,	,
cord-015021-pol2qm74	1428	25	such	such	JJ
cord-015021-pol2qm74	1428	26	as	as	IN
cord-015021-pol2qm74	1428	27	growth	growth	NN
cord-015021-pol2qm74	1428	28	factors	factor	NNS
cord-015021-pol2qm74	1428	29	that	that	WDT
cord-015021-pol2qm74	1428	30	inhibit	inhibit	VBP
cord-015021-pol2qm74	1428	31	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1428	32	and	and	CC
cord-015021-pol2qm74	1428	33	allow	allow	VB
cord-015021-pol2qm74	1428	34	the	the	DT
cord-015021-pol2qm74	1428	35	ceils	ceil	NNS
cord-015021-pol2qm74	1428	36	to	to	TO
cord-015021-pol2qm74	1428	37	proliferate	proliferate	VB
cord-015021-pol2qm74	1428	38	.	.	.
cord-015021-pol2qm74	1429	1	Thus	thus	RB
cord-015021-pol2qm74	1429	2	,	,	,
cord-015021-pol2qm74	1429	3	c	c	NN
cord-015021-pol2qm74	1429	4	-	-	HYPH
cord-015021-pol2qm74	1429	5	Myc	Myc	NNP
cord-015021-pol2qm74	1429	6	directs	direct	VBZ
cord-015021-pol2qm74	1429	7	cells	cell	NNS
cord-015021-pol2qm74	1429	8	out	out	IN
cord-015021-pol2qm74	1429	9	of	of	IN
cord-015021-pol2qm74	1429	10	rest	rest	NN
cord-015021-pol2qm74	1429	11	and	and	CC
cord-015021-pol2qm74	1429	12	the	the	DT
cord-015021-pol2qm74	1429	13	choice	choice	NN
cord-015021-pol2qm74	1429	14	of	of	IN
cord-015021-pol2qm74	1429	15	proliferation	proliferation	NN
cord-015021-pol2qm74	1429	16	or	or	CC
cord-015021-pol2qm74	1429	17	death	death	NN
cord-015021-pol2qm74	1429	18	depends	depend	VBZ
cord-015021-pol2qm74	1429	19	upon	upon	IN
cord-015021-pol2qm74	1429	20	the	the	DT
cord-015021-pol2qm74	1429	21	presence	presence	NN
cord-015021-pol2qm74	1429	22	or	or	CC
cord-015021-pol2qm74	1429	23	absence	absence	NN
cord-015021-pol2qm74	1429	24	of	of	IN
cord-015021-pol2qm74	1429	25	survival	survival	NN
cord-015021-pol2qm74	1429	26	signals	signal	NNS
cord-015021-pol2qm74	1429	27	.	.	.
cord-015021-pol2qm74	1430	1	Other	other	JJ
cord-015021-pol2qm74	1430	2	survival	survival	NN
cord-015021-pol2qm74	1430	3	signals	signal	NNS
cord-015021-pol2qm74	1430	4	are	be	VBP
cord-015021-pol2qm74	1430	5	generated	generate	VBN
cord-015021-pol2qm74	1430	6	by	by	IN
cord-015021-pol2qm74	1430	7	oncogene	oncogene	NN
cord-015021-pol2qm74	1430	8	productS	productS	NNP
cord-015021-pol2qm74	1430	9	that	that	WDT
cord-015021-pol2qm74	1430	10	can	can	MD
cord-015021-pol2qm74	1430	11	cooperate	cooperate	VB
cord-015021-pol2qm74	1430	12	with	with	IN
cord-015021-pol2qm74	1430	13	My¢	My¢	NNS
cord-015021-pol2qm74	1430	14	,	,	,
cord-015021-pol2qm74	1430	15	including	include	VBG
cord-015021-pol2qm74	1430	16	Bcl-2	Bcl-2	NNP
cord-015021-pol2qm74	1430	17	and	and	CC
cord-015021-pol2qm74	1430	18	AbL	abl	NN
cord-015021-pol2qm74	1431	1	There	there	EX
cord-015021-pol2qm74	1431	2	are	be	VBP
cord-015021-pol2qm74	1431	3	implications	implication	NNS
cord-015021-pol2qm74	1431	4	of	of	IN
cord-015021-pol2qm74	1431	5	this	this	DT
cord-015021-pol2qm74	1431	6	interplay	interplay	NN
cord-015021-pol2qm74	1431	7	between	between	IN
cord-015021-pol2qm74	1431	8	apoptotie	apoptotie	NN
cord-015021-pol2qm74	1431	9	and	and	CC
cord-015021-pol2qm74	1431	10	anti	anti	JJ
cord-015021-pol2qm74	1431	11	-	-	JJ
cord-015021-pol2qm74	1431	12	apoptorlc	apoptorlc	JJ
cord-015021-pol2qm74	1431	13	signals	signal	NNS
cord-015021-pol2qm74	1431	14	in	in	IN
cord-015021-pol2qm74	1431	15	cell	cell	NN
cord-015021-pol2qm74	1431	16	Iransformation	Iransformation	NNP
cord-015021-pol2qm74	1431	17	and	and	CC
cord-015021-pol2qm74	1431	18	the	the	DT
cord-015021-pol2qm74	1431	19	resistance	resistance	NN
cord-015021-pol2qm74	1431	20	of	of	IN
cord-015021-pol2qm74	1431	21	some	some	DT
cord-015021-pol2qm74	1431	22	tumor	tumor	NN
cord-015021-pol2qm74	1431	23	ceils	ceil	NNS
cord-015021-pol2qm74	1431	24	to	to	IN
cord-015021-pol2qm74	1431	25	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1431	26	agents	agent	NNS
cord-015021-pol2qm74	1431	27	capable	capable	JJ
cord-015021-pol2qm74	1431	28	of	of	IN
cord-015021-pol2qm74	1431	29	inducing	induce	VBG
cord-015021-pol2qm74	1431	30	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1431	31	.	.	.
cord-015021-pol2qm74	1432	1	Oncogene	oncogene	NN
cord-015021-pol2qm74	1432	2	interactions	interaction	NNS
cord-015021-pol2qm74	1432	3	therefore	therefore	RB
cord-015021-pol2qm74	1432	4	control	control	VBP
cord-015021-pol2qm74	1432	5	the	the	DT
cord-015021-pol2qm74	1432	6	life	life	NN
cord-015021-pol2qm74	1432	7	or	or	CC
cord-015021-pol2qm74	1432	8	death	death	NN
cord-015021-pol2qm74	1432	9	of	of	IN
cord-015021-pol2qm74	1432	10	transformed	transformed	JJ
cord-015021-pol2qm74	1432	11	ceils	ceil	NNS
cord-015021-pol2qm74	1432	12	but	but	CC
cord-015021-pol2qm74	1432	13	also	also	RB
cord-015021-pol2qm74	1432	14	have	have	VBP
cord-015021-pol2qm74	1432	15	important	important	JJ
cord-015021-pol2qm74	1432	16	roles	role	NNS
cord-015021-pol2qm74	1432	17	in	in	IN
cord-015021-pol2qm74	1432	18	normal	normal	JJ
cord-015021-pol2qm74	1432	19	,	,	,
cord-015021-pol2qm74	1432	20	development	development	NN
cord-015021-pol2qm74	1432	21	processes	process	NNS
cord-015021-pol2qm74	1432	22	.	.	.
cord-015021-pol2qm74	1433	1	In	in	IN
cord-015021-pol2qm74	1433	2	the	the	DT
cord-015021-pol2qm74	1433	3	immune	immune	JJ
cord-015021-pol2qm74	1433	4	system	system	NN
cord-015021-pol2qm74	1433	5	,	,	,
cord-015021-pol2qm74	1433	6	developing	develop	VBG
cord-015021-pol2qm74	1433	7	T	T	NNP
cord-015021-pol2qm74	1433	8	ceils	ceil	NNS
cord-015021-pol2qm74	1433	9	are	be	VBP
cord-015021-pol2qm74	1433	10	"	"	``
cord-015021-pol2qm74	1433	11	screened	screen	VBN
cord-015021-pol2qm74	1433	12	"	"	''
cord-015021-pol2qm74	1433	13	for	for	IN
cord-015021-pol2qm74	1433	14	potential	potential	JJ
cord-015021-pol2qm74	1433	15	self	self	NN
cord-015021-pol2qm74	1433	16	-	-	HYPH
cord-015021-pol2qm74	1433	17	reactivity	reactivity	NN
cord-015021-pol2qm74	1433	18	by	by	IN
cord-015021-pol2qm74	1433	19	a	a	DT
cord-015021-pol2qm74	1433	20	process	process	NN
cord-015021-pol2qm74	1433	21	of	of	IN
cord-015021-pol2qm74	1433	22	negative	negative	JJ
cord-015021-pol2qm74	1433	23	selection	selection	NN
cord-015021-pol2qm74	1433	24	,	,	,
cord-015021-pol2qm74	1433	25	in	in	IN
cord-015021-pol2qm74	1433	26	which	which	WDT
cord-015021-pol2qm74	1433	27	activation	activation	NN
cord-015021-pol2qm74	1433	28	via	via	IN
cord-015021-pol2qm74	1433	29	the	the	DT
cord-015021-pol2qm74	1433	30	T	T	NNP
cord-015021-pol2qm74	1433	31	cell	cell	NN
cord-015021-pol2qm74	1433	32	receptor	receptor	NN
cord-015021-pol2qm74	1433	33	(	(	-LRB-
cord-015021-pol2qm74	1433	34	TCR	TCR	NNP
cord-015021-pol2qm74	1433	35	)	)	-RRB-
cord-015021-pol2qm74	1433	36	induces	induce	VBZ
cord-015021-pol2qm74	1433	37	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1433	38	.	.	.
cord-015021-pol2qm74	1434	1	This	this	DT
cord-015021-pol2qm74	1434	2	process	process	NN
cord-015021-pol2qm74	1434	3	can	can	MD
cord-015021-pol2qm74	1434	4	be	be	VB
cord-015021-pol2qm74	1434	5	mimicked	mimic	VBN
cord-015021-pol2qm74	1434	6	in	in	IN
cord-015021-pol2qm74	1434	7	T	T	NNP
cord-015021-pol2qm74	1434	8	cell	cell	NN
cord-015021-pol2qm74	1434	9	hybridomas	hybridomas	NN
cord-015021-pol2qm74	1434	10	,	,	,
cord-015021-pol2qm74	1434	11	and	and	CC
cord-015021-pol2qm74	1434	12	appears	appear	VBZ
cord-015021-pol2qm74	1434	13	to	to	TO
cord-015021-pol2qm74	1434	14	depend	depend	VB
cord-015021-pol2qm74	1434	15	upon	upon	IN
cord-015021-pol2qm74	1434	16	the	the	DT
cord-015021-pol2qm74	1434	17	expression	expression	NN
cord-015021-pol2qm74	1434	18	of	of	IN
cord-015021-pol2qm74	1434	19	the	the	DT
cord-015021-pol2qm74	1434	20	c	c	NNP
cord-015021-pol2qm74	1434	21	-	-	HYPH
cord-015021-pol2qm74	1434	22	Mye	Mye	NNP
cord-015021-pol2qm74	1434	23	protein	protein	NN
cord-015021-pol2qm74	1434	24	.	.	.
cord-015021-pol2qm74	1435	1	Evidence	evidence	NN
cord-015021-pol2qm74	1435	2	that	that	IN
cord-015021-pol2qm74	1435	3	this	this	DT
cord-015021-pol2qm74	1435	4	represents	represent	VBZ
cord-015021-pol2qm74	1435	5	a	a	DT
cord-015021-pol2qm74	1435	6	requirement	requirement	NN
cord-015021-pol2qm74	1435	7	for	for	IN
cord-015021-pol2qm74	1435	8	the	the	DT
cord-015021-pol2qm74	1435	9	Myc	Myc	NNP
cord-015021-pol2qm74	1435	10	/	/	SYM
cord-015021-pol2qm74	1435	11	Max	Max	NNP
cord-015021-pol2qm74	1435	12	heterodimer	heterodimer	NN
cord-015021-pol2qm74	1435	13	will	will	MD
cord-015021-pol2qm74	1435	14	be	be	VB
cord-015021-pol2qm74	1435	15	presented	present	VBN
cord-015021-pol2qm74	1435	16	.	.	.
cord-015021-pol2qm74	1436	1	As	as	IN
cord-015021-pol2qm74	1436	2	above	above	RB
cord-015021-pol2qm74	1436	3	,	,	,
cord-015021-pol2qm74	1436	4	these	these	DT
cord-015021-pol2qm74	1436	5	cells	cell	NNS
cord-015021-pol2qm74	1436	6	are	be	VBP
cord-015021-pol2qm74	1436	7	presented	present	VBN
cord-015021-pol2qm74	1436	8	with	with	IN
cord-015021-pol2qm74	1436	9	the	the	DT
cord-015021-pol2qm74	1436	10	"	"	``
cord-015021-pol2qm74	1436	11	choice	choice	NN
cord-015021-pol2qm74	1436	12	"	"	''
cord-015021-pol2qm74	1436	13	to	to	TO
cord-015021-pol2qm74	1436	14	proliferate	proliferate	VB
cord-015021-pol2qm74	1436	15	or	or	CC
cord-015021-pol2qm74	1436	16	die	die	VB
cord-015021-pol2qm74	1436	17	and	and	CC
cord-015021-pol2qm74	1436	18	this	this	DT
cord-015021-pol2qm74	1436	19	depends	depend	VBZ
cord-015021-pol2qm74	1436	20	not	not	RB
cord-015021-pol2qm74	1436	21	only	only	RB
cord-015021-pol2qm74	1436	22	upon	upon	IN
cord-015021-pol2qm74	1436	23	Myc	Myc	NNP
cord-015021-pol2qm74	1436	24	but	but	CC
cord-015021-pol2qm74	1436	25	also	also	RB
cord-015021-pol2qm74	1436	26	other	other	JJ
cord-015021-pol2qm74	1436	27	signals	signal	NNS
cord-015021-pol2qm74	1436	28	.	.	.
cord-015021-pol2qm74	1437	1	Thus	thus	RB
cord-015021-pol2qm74	1437	2	,	,	,
cord-015021-pol2qm74	1437	3	expression	expression	NN
cord-015021-pol2qm74	1437	4	of	of	IN
cord-015021-pol2qm74	1437	5	functional	functional	JJ
cord-015021-pol2qm74	1437	6	v	v	NN
cord-015021-pol2qm74	1437	7	-	-	:
cord-015021-pol2qm74	1437	8	AN	an	DT
cord-015021-pol2qm74	1437	9	kinase	kinase	NN
cord-015021-pol2qm74	1437	10	in	in	IN
cord-015021-pol2qm74	1437	11	these	these	DT
cord-015021-pol2qm74	1437	12	ceils	ceil	NNS
cord-015021-pol2qm74	1437	13	can	can	MD
cord-015021-pol2qm74	1437	14	render	render	VB
cord-015021-pol2qm74	1437	15	them	-PRON-	PRP
cord-015021-pol2qm74	1437	16	resistant	resistant	JJ
cord-015021-pol2qm74	1437	17	to	to	IN
cord-015021-pol2qm74	1437	18	the	the	DT
cord-015021-pol2qm74	1437	19	activation	activation	NN
cord-015021-pol2qm74	1437	20	of	of	IN
cord-015021-pol2qm74	1437	21	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1437	22	via	via	IN
cord-015021-pol2qm74	1437	23	TCR	TCR	NNP
cord-015021-pol2qm74	1437	24	ligation	ligation	NN
cord-015021-pol2qm74	1437	25	,	,	,
cord-015021-pol2qm74	1437	26	Surprisingly	surprisingly	RB
cord-015021-pol2qm74	1437	27	,	,	,
cord-015021-pol2qm74	1437	28	Bcl-2	Bcl-2	NNP
cord-015021-pol2qm74	1437	29	does	do	VBZ
cord-015021-pol2qm74	1437	30	not	not	RB
cord-015021-pol2qm74	1437	31	appear	appear	VB
cord-015021-pol2qm74	1437	32	to	to	TO
cord-015021-pol2qm74	1437	33	be	be	VB
cord-015021-pol2qm74	1437	34	capable	capable	JJ
cord-015021-pol2qm74	1437	35	of	of	IN
cord-015021-pol2qm74	1437	36	blocking	block	VBG
cord-015021-pol2qm74	1437	37	this	this	DT
cord-015021-pol2qm74	1437	38	form	form	NN
cord-015021-pol2qm74	1437	39	of	of	IN
cord-015021-pol2qm74	1437	40	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1437	41	,	,	,
cord-015021-pol2qm74	1437	42	and	and	CC
cord-015021-pol2qm74	1437	43	the	the	DT
cord-015021-pol2qm74	1437	44	reasons	reason	NNS
cord-015021-pol2qm74	1437	45	for	for	IN
cord-015021-pol2qm74	1437	46	this	this	DT
cord-015021-pol2qm74	1437	47	will	will	MD
cord-015021-pol2qm74	1437	48	provide	provide	VB
cord-015021-pol2qm74	1437	49	new	new	JJ
cord-015021-pol2qm74	1437	50	insights	insight	NNS
cord-015021-pol2qm74	1437	51	into	into	IN
cord-015021-pol2qm74	1437	52	the	the	DT
cord-015021-pol2qm74	1437	53	development	development	NN
cord-015021-pol2qm74	1437	54	of	of	IN
cord-015021-pol2qm74	1437	55	the	the	DT
cord-015021-pol2qm74	1437	56	immune	immune	JJ
cord-015021-pol2qm74	1437	57	system	system	NN
cord-015021-pol2qm74	1437	58	and	and	CC
cord-015021-pol2qm74	1437	59	the	the	DT
cord-015021-pol2qm74	1437	60	process	process	NN
cord-015021-pol2qm74	1437	61	of	of	IN
cord-015021-pol2qm74	1437	62	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1437	63	.	.	.
cord-015021-pol2qm74	1438	1	Although	although	IN
cord-015021-pol2qm74	1438	2	the	the	DT
cord-015021-pol2qm74	1438	3	oncogene	oncogene	NN
cord-015021-pol2qm74	1438	4	products	product	NNS
cord-015021-pol2qm74	1438	5	discussed	discuss	VBN
cord-015021-pol2qm74	1438	6	here	here	RB
cord-015021-pol2qm74	1438	7	probably	probably	RB
cord-015021-pol2qm74	1438	8	do	do	VBP
cord-015021-pol2qm74	1438	9	not	not	RB
cord-015021-pol2qm74	1438	10	directly	directly	RB
cord-015021-pol2qm74	1438	11	participate	participate	VB
cord-015021-pol2qm74	1438	12	in	in	IN
cord-015021-pol2qm74	1438	13	the	the	DT
cord-015021-pol2qm74	1438	14	biochemical	biochemical	JJ
cord-015021-pol2qm74	1438	15	process	process	NN
cord-015021-pol2qm74	1438	16	of	of	IN
cord-015021-pol2qm74	1438	17	apoptosis	apoptosis	NN
cord-015021-pol2qm74	1438	18	,	,	,
cord-015021-pol2qm74	1438	19	they	-PRON-	PRP
cord-015021-pol2qm74	1438	20	represent	represent	VBP
cord-015021-pol2qm74	1438	21	molecular	molecular	JJ
cord-015021-pol2qm74	1438	22	controls	control	NNS
cord-015021-pol2qm74	1438	23	on	on	IN
cord-015021-pol2qm74	1438	24	this	this	DT
cord-015021-pol2qm74	1438	25	complex	complex	JJ
cord-015021-pol2qm74	1438	26	mechanism	mechanism	NN
cord-015021-pol2qm74	1438	27	.	.	.
cord-015021-pol2qm74	1439	1	As	as	IN
cord-015021-pol2qm74	1439	2	such	such	JJ
cord-015021-pol2qm74	1439	3	,	,	,
cord-015021-pol2qm74	1439	4	they	-PRON-	PRP
cord-015021-pol2qm74	1439	5	gave	give	VBD
cord-015021-pol2qm74	1439	6	us	-PRON-	PRP
cord-015021-pol2qm74	1439	7	new	new	JJ
cord-015021-pol2qm74	1439	8	ways	way	NNS
cord-015021-pol2qm74	1439	9	to	to	TO
cord-015021-pol2qm74	1439	10	look	look	VB
cord-015021-pol2qm74	1439	11	at	at	IN
cord-015021-pol2qm74	1439	12	the	the	DT
cord-015021-pol2qm74	1439	13	life	life	NN
cord-015021-pol2qm74	1439	14	and	and	CC
cord-015021-pol2qm74	1439	15	death	death	NN
cord-015021-pol2qm74	1439	16	of	of	IN
cord-015021-pol2qm74	1439	17	a	a	DT
cord-015021-pol2qm74	1439	18	cell	cell	NN
cord-015021-pol2qm74	1440	1	Recent	recent	JJ
cord-015021-pol2qm74	1440	2	attention	attention	NN
cord-015021-pol2qm74	1440	3	has	have	VBZ
cord-015021-pol2qm74	1440	4	focused	focus	VBN
cord-015021-pol2qm74	1440	5	on	on	IN
cord-015021-pol2qm74	1440	6	macrophage	macrophage	NN
cord-015021-pol2qm74	1440	7	release	release	NN
cord-015021-pol2qm74	1440	8	of	of	IN
cord-015021-pol2qm74	1440	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	1440	10	,	,	,
cord-015021-pol2qm74	1440	11	such	such	JJ
cord-015021-pol2qm74	1440	12	as	as	IN
cord-015021-pol2qm74	1440	13	IL-1	IL-1	NNP
cord-015021-pol2qm74	1440	14	,	,	,
cord-015021-pol2qm74	1440	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	1440	16	and	and	CC
cord-015021-pol2qm74	1440	17	TNF	TNF	NNP
cord-015021-pol2qm74	1440	18	as	as	IN
cord-015021-pol2qm74	1440	19	important	important	JJ
cord-015021-pol2qm74	1440	20	mediators	mediator	NNS
cord-015021-pol2qm74	1440	21	of	of	IN
cord-015021-pol2qm74	1440	22	septic	septic	JJ
cord-015021-pol2qm74	1440	23	shock	shock	NN
cord-015021-pol2qm74	1440	24	.	.	.
cord-015021-pol2qm74	1441	1	However	however	RB
cord-015021-pol2qm74	1441	2	,	,	,
cord-015021-pol2qm74	1441	3	serum	serum	NN
cord-015021-pol2qm74	1441	4	cytokine	cytokine	NN
cord-015021-pol2qm74	1441	5	levels	level	NNS
cord-015021-pol2qm74	1441	6	have	have	VBP
cord-015021-pol2qm74	1441	7	correlated	correlate	VBN
cord-015021-pol2qm74	1441	8	poorly	poorly	RB
cord-015021-pol2qm74	1441	9	with	with	IN
cord-015021-pol2qm74	1441	10	outcome	outcome	NN
cord-015021-pol2qm74	1441	11	of	of	IN
cord-015021-pol2qm74	1441	12	septic	septic	JJ
cord-015021-pol2qm74	1441	13	shock	shock	NN
cord-015021-pol2qm74	1441	14	.	.	.
cord-015021-pol2qm74	1442	1	The	the	DT
cord-015021-pol2qm74	1442	2	purpose	purpose	NN
cord-015021-pol2qm74	1442	3	of	of	IN
cord-015021-pol2qm74	1442	4	this	this	DT
cord-015021-pol2qm74	1442	5	study	study	NN
cord-015021-pol2qm74	1442	6	was	be	VBD
cord-015021-pol2qm74	1442	7	to	to	TO
cord-015021-pol2qm74	1442	8	compare	compare	VB
cord-015021-pol2qm74	1442	9	the	the	DT
cord-015021-pol2qm74	1442	10	functional	functional	JJ
cord-015021-pol2qm74	1442	11	status	status	NN
cord-015021-pol2qm74	1442	12	of	of	IN
cord-015021-pol2qm74	1442	13	macrophages	macrophage	NNS
cord-015021-pol2qm74	1442	14	to	to	IN
cord-015021-pol2qm74	1442	15	serum	serum	VB
cord-015021-pol2qm74	1442	16	cytokine	cytokine	JJ
cord-015021-pol2qm74	1442	17	levels	level	NNS
cord-015021-pol2qm74	1442	18	in	in	IN
cord-015021-pol2qm74	1442	19	early	early	JJ
cord-015021-pol2qm74	1442	20	sepsis	sepsis	NN
cord-015021-pol2qm74	1442	21	by	by	IN
cord-015021-pol2qm74	1442	22	an	an	DT
cord-015021-pol2qm74	1442	23	analysis	analysis	NN
cord-015021-pol2qm74	1442	24	of	of	IN
cord-015021-pol2qm74	1442	25	splenic	splenic	JJ
cord-015021-pol2qm74	1442	26	macrophage	macrophage	NN
cord-015021-pol2qm74	1442	27	protein	protein	NN
cord-015021-pol2qm74	1442	28	synthesis	synthesis	NN
cord-015021-pol2qm74	1442	29	during	during	IN
cord-015021-pol2qm74	1442	30	abdominal	abdominal	JJ
cord-015021-pol2qm74	1442	31	sepsis	sepsis	NN
cord-015021-pol2qm74	1442	32	.	.	.
cord-015021-pol2qm74	1443	1	Macrophage	macrophage	NN
cord-015021-pol2qm74	1443	2	total	total	JJ
cord-015021-pol2qm74	1443	3	protein	protein	NN
cord-015021-pol2qm74	1443	4	distribution	distribution	NN
cord-015021-pol2qm74	1443	5	and	and	CC
cord-015021-pol2qm74	1443	6	biosynthetic	biosynthetic	JJ
cord-015021-pol2qm74	1443	7	activity	activity	NN
cord-015021-pol2qm74	1443	8	was	be	VBD
cord-015021-pol2qm74	1443	9	assessed	assess	VBN
cord-015021-pol2qm74	1443	10	by	by	IN
cord-015021-pol2qm74	1443	11	large	large	JJ
cord-015021-pol2qm74	1443	12	format	format	NN
cord-015021-pol2qm74	1443	13	2-D	2-D	NNP
cord-015021-pol2qm74	1443	14	PAGE	page	NN
cord-015021-pol2qm74	1443	15	,	,	,
cord-015021-pol2qm74	1443	16	autoradiography	autoradiography	NN
cord-015021-pol2qm74	1443	17	of	of	IN
cord-015021-pol2qm74	1443	18	35S	35S	NNP
cord-015021-pol2qm74	1443	19	-	-	HYPH
cord-015021-pol2qm74	1443	20	labeled	label	VBN
cord-015021-pol2qm74	1443	21	proteins	protein	NNS
cord-015021-pol2qm74	1443	22	and	and	CC
cord-015021-pol2qm74	1443	23	computer	computer	NN
cord-015021-pol2qm74	1443	24	assisted	assist	VBN
cord-015021-pol2qm74	1443	25	densitometric	densitometric	JJ
cord-015021-pol2qm74	1443	26	analysis	analysis	NN
cord-015021-pol2qm74	1443	27	.	.	.
cord-015021-pol2qm74	1444	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	1444	2	was	be	VBD
cord-015021-pol2qm74	1444	3	induced	induce	VBN
cord-015021-pol2qm74	1444	4	in	in	IN
cord-015021-pol2qm74	1444	5	Sprague	Sprague	NNP
cord-015021-pol2qm74	1444	6	Dawley	Dawley	NNP
cord-015021-pol2qm74	1444	7	mts	mts	NNP
cord-015021-pol2qm74	1444	8	by	by	IN
cord-015021-pol2qm74	1444	9	cecal	cecal	JJ
cord-015021-pol2qm74	1444	10	ligation	ligation	NN
cord-015021-pol2qm74	1444	11	and	and	CC
cord-015021-pol2qm74	1444	12	puncture	puncture	NN
cord-015021-pol2qm74	1444	13	(	(	-LRB-
cord-015021-pol2qm74	1444	14	CLP	CLP	NNP
cord-015021-pol2qm74	1444	15	)	)	-RRB-
cord-015021-pol2qm74	1444	16	.	.	.
cord-015021-pol2qm74	1445	1	Untreated	untreated	JJ
cord-015021-pol2qm74	1445	2	and	and	CC
cord-015021-pol2qm74	1445	3	sham	sham	NN
cord-015021-pol2qm74	1445	4	operated	operate	VBD
cord-015021-pol2qm74	1445	5	rats	rat	NNS
cord-015021-pol2qm74	1445	6	served	serve	VBD
cord-015021-pol2qm74	1445	7	as	as	IN
cord-015021-pol2qm74	1445	8	controls	control	NNS
cord-015021-pol2qm74	1445	9	.	.	.
cord-015021-pol2qm74	1446	1	Splenic	splenic	JJ
cord-015021-pol2qm74	1446	2	macrophages	macrophage	NNS
cord-015021-pol2qm74	1446	3	were	be	VBD
cord-015021-pol2qm74	1446	4	harvested	harvest	VBN
cord-015021-pol2qm74	1446	5	at	at	IN
cord-015021-pol2qm74	1446	6	3	3	CD
cord-015021-pol2qm74	1446	7	and	and	CC
cord-015021-pol2qm74	1446	8	24	24	CD
cord-015021-pol2qm74	1446	9	hrs	hrs	NN
cord-015021-pol2qm74	1446	10	.	.	.
cord-015021-pol2qm74	1447	1	following	follow	VBG
cord-015021-pol2qm74	1447	2	CLP	CLP	NNP
cord-015021-pol2qm74	1447	3	.	.	.
cord-015021-pol2qm74	1448	1	Serum	serum	NN
cord-015021-pol2qm74	1448	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	1448	3	levels	level	NNS
cord-015021-pol2qm74	1448	4	were	be	VBD
cord-015021-pol2qm74	1448	5	determined	determine	VBN
cord-015021-pol2qm74	1448	6	at	at	IN
cord-015021-pol2qm74	1448	7	3,12	3,12	CD
cord-015021-pol2qm74	1448	8	,	,	,
cord-015021-pol2qm74	1448	9	and	and	CC
cord-015021-pol2qm74	1448	10	24	24	CD
cord-015021-pol2qm74	1448	11	hours	hour	NNS
cord-015021-pol2qm74	1448	12	by	by	IN
cord-015021-pol2qm74	1448	13	the	the	DT
cord-015021-pol2qm74	1448	14	7	7	CD
cord-015021-pol2qm74	1448	15	TDI	TDI	NNP
cord-015021-pol2qm74	1448	16	bioassay	bioassay	NN
cord-015021-pol2qm74	1448	17	.	.	.
cord-015021-pol2qm74	1449	1	By	by	IN
cord-015021-pol2qm74	1449	2	12	12	CD
cord-015021-pol2qm74	1449	3	hrs	hrs	NN
cord-015021-pol2qm74	1449	4	.	.	.
cord-015021-pol2qm74	1450	1	100	100	CD
cord-015021-pol2qm74	1450	2	%	%	NN
cord-015021-pol2qm74	1450	3	of	of	IN
cord-015021-pol2qm74	1450	4	the	the	DT
cord-015021-pol2qm74	1450	5	CLP	CLP	NNP
cord-015021-pol2qm74	1450	6	mls	mls	NNP
cord-015021-pol2qm74	1450	7	exhibited	exhibit	VBD
cord-015021-pol2qm74	1450	8	multi	multi	JJ
cord-015021-pol2qm74	1450	9	-	-	JJ
cord-015021-pol2qm74	1450	10	microbiaJ	microbiaj	JJ
cord-015021-pol2qm74	1450	11	bacteremia	bacteremia	NN
cord-015021-pol2qm74	1450	12	.	.	.
cord-015021-pol2qm74	1451	1	Control	control	NN
cord-015021-pol2qm74	1451	2	or	or	CC
cord-015021-pol2qm74	1451	3	sham	sham	NN
cord-015021-pol2qm74	1451	4	operated	operate	VBD
cord-015021-pol2qm74	1451	5	rats	rat	NNS
cord-015021-pol2qm74	1451	6	did	do	VBD
cord-015021-pol2qm74	1451	7	not	not	RB
cord-015021-pol2qm74	1451	8	show	show	VB
cord-015021-pol2qm74	1451	9	bacteremia	bacteremia	NN
cord-015021-pol2qm74	1451	10	.	.	.
cord-015021-pol2qm74	1452	1	CLP	CLP	NNP
cord-015021-pol2qm74	1452	2	resulted	result	VBD
cord-015021-pol2qm74	1452	3	in	in	IN
cord-015021-pol2qm74	1452	4	a	a	DT
cord-015021-pol2qm74	1452	5	significant	significant	JJ
cord-015021-pol2qm74	1452	6	286	286	CD
cord-015021-pol2qm74	1452	7	%	%	NN
cord-015021-pol2qm74	1452	8	elevation	elevation	NN
cord-015021-pol2qm74	1452	9	(	(	-LRB-
cord-015021-pol2qm74	1452	10	p	p	NN
cord-015021-pol2qm74	1452	11	<	<	XX
cord-015021-pol2qm74	1452	12	0.05	0.05	CD
cord-015021-pol2qm74	1452	13	)	)	-RRB-
cord-015021-pol2qm74	1452	14	in	in	IN
cord-015021-pol2qm74	1452	15	serum	serum	NN
cord-015021-pol2qm74	1452	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	1452	17	levels	level	NNS
cord-015021-pol2qm74	1452	18	at	at	IN
cord-015021-pol2qm74	1452	19	12	12	CD
cord-015021-pol2qm74	1452	20	hrs	hrs	NN
cord-015021-pol2qm74	1452	21	.	.	.
cord-015021-pol2qm74	1453	1	There	there	EX
cord-015021-pol2qm74	1453	2	was	be	VBD
cord-015021-pol2qm74	1453	3	no	no	DT
cord-015021-pol2qm74	1453	4	difference	difference	NN
cord-015021-pol2qm74	1453	5	in	in	IN
cord-015021-pol2qm74	1453	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	1453	7	at	at	IN
cord-015021-pol2qm74	1453	8	3	3	CD
cord-015021-pol2qm74	1453	9	and	and	CC
cord-015021-pol2qm74	1453	10	24	24	CD
cord-015021-pol2qm74	1453	11	hrs	hrs	NN
cord-015021-pol2qm74	1453	12	.	.	.
cord-015021-pol2qm74	1454	1	when	when	WRB
cord-015021-pol2qm74	1454	2	compared	compare	VBN
cord-015021-pol2qm74	1454	3	to	to	IN
cord-015021-pol2qm74	1454	4	the	the	DT
cord-015021-pol2qm74	1454	5	control	control	NN
cord-015021-pol2qm74	1454	6	groups	group	NNS
cord-015021-pol2qm74	1454	7	.	.	.
cord-015021-pol2qm74	1455	1	2D	2D	NNP
cord-015021-pol2qm74	1455	2	PAGE	PAGE	NNP
cord-015021-pol2qm74	1455	3	studies	study	NNS
cord-015021-pol2qm74	1455	4	examined	examine	VBD
cord-015021-pol2qm74	1455	5	splenic	splenic	JJ
cord-015021-pol2qm74	1455	6	macrophage	macrophage	NN
cord-015021-pol2qm74	1455	7	total	total	JJ
cord-015021-pol2qm74	1455	8	protein	protein	NN
cord-015021-pol2qm74	1455	9	distribution	distribution	NN
cord-015021-pol2qm74	1455	10	and	and	CC
cord-015021-pol2qm74	1455	11	biosynthetic	biosynthetic	JJ
cord-015021-pol2qm74	1455	12	activity	activity	NN
cord-015021-pol2qm74	1455	13	at	at	IN
cord-015021-pol2qm74	1455	14	3	3	CD
cord-015021-pol2qm74	1455	15	and	and	CC
cord-015021-pol2qm74	1455	16	24	24	CD
cord-015021-pol2qm74	1455	17	hrs	hrs	NN
cord-015021-pol2qm74	1455	18	.	.	.
cord-015021-pol2qm74	1456	1	post	post	JJ
cord-015021-pol2qm74	1456	2	-	-	JJ
cord-015021-pol2qm74	1456	3	CLP	CLP	NNP
cord-015021-pol2qm74	1456	4	.	.	.
cord-015021-pol2qm74	1457	1	At	at	IN
cord-015021-pol2qm74	1457	2	3	3	CD
cord-015021-pol2qm74	1457	3	hrs	hrs	NN
cord-015021-pol2qm74	1457	4	.	.	.
cord-015021-pol2qm74	1458	1	macrophages	macrophage	NNS
cord-015021-pol2qm74	1458	2	from	from	IN
cord-015021-pol2qm74	1458	3	CLP	CLP	NNP
cord-015021-pol2qm74	1458	4	rats	rat	NNS
cord-015021-pol2qm74	1458	5	showed	show	VBD
cord-015021-pol2qm74	1458	6	a	a	DT
cord-015021-pol2qm74	1458	7	substantial	substantial	JJ
cord-015021-pol2qm74	1458	8	decrease	decrease	NN
cord-015021-pol2qm74	1458	9	in	in	IN
cord-015021-pol2qm74	1458	10	total	total	JJ
cord-015021-pol2qm74	1458	11	protein	protein	NN
cord-015021-pol2qm74	1458	12	pattern	pattern	NN
cord-015021-pol2qm74	1458	13	(	(	-LRB-
cord-015021-pol2qm74	1458	14	353	353	CD
cord-015021-pol2qm74	1458	15	protein	protein	NN
cord-015021-pol2qm74	1458	16	spots	spot	NNS
cord-015021-pol2qm74	1458	17	vs	vs	IN
cord-015021-pol2qm74	1458	18	503	503	CD
cord-015021-pol2qm74	1458	19	protein	protein	NN
cord-015021-pol2qm74	1458	20	spots	spot	NNS
cord-015021-pol2qm74	1458	21	)	)	-RRB-
cord-015021-pol2qm74	1458	22	when	when	WRB
cord-015021-pol2qm74	1458	23	compared	compare	VBN
cord-015021-pol2qm74	1458	24	to	to	IN
cord-015021-pol2qm74	1458	25	non	non	JJ
cord-015021-pol2qm74	1458	26	-	-	JJ
cord-015021-pol2qm74	1458	27	septic	septic	JJ
cord-015021-pol2qm74	1458	28	control	control	NN
cord-015021-pol2qm74	1458	29	macrophages	macrophage	NNS
cord-015021-pol2qm74	1458	30	.	.	.
cord-015021-pol2qm74	1459	1	A	a	DT
cord-015021-pol2qm74	1459	2	decrease	decrease	NN
cord-015021-pol2qm74	1459	3	in	in	IN
cord-015021-pol2qm74	1459	4	the	the	DT
cord-015021-pol2qm74	1459	5	number	number	NN
cord-015021-pol2qm74	1459	6	of	of	IN
cord-015021-pol2qm74	1459	7	lower	low	JJR
cord-015021-pol2qm74	1459	8	molecular	molecular	JJ
cord-015021-pol2qm74	1459	9	weight	weight	NN
cord-015021-pol2qm74	1459	10	proteins	protein	NNS
cord-015021-pol2qm74	1459	11	(	(	-LRB-
cord-015021-pol2qm74	1459	12	<	<	XX
cord-015021-pol2qm74	1459	13	40	40	CD
cord-015021-pol2qm74	1459	14	kD	kd	ADD
cord-015021-pol2qm74	1459	15	)	)	-RRB-
cord-015021-pol2qm74	1459	16	was	be	VBD
cord-015021-pol2qm74	1459	17	observed	observe	VBN
cord-015021-pol2qm74	1459	18	.	.	.
cord-015021-pol2qm74	1460	1	At	at	IN
cord-015021-pol2qm74	1460	2	24	24	CD
cord-015021-pol2qm74	1460	3	hrs	hrs	NN
cord-015021-pol2qm74	1460	4	.	.	.
cord-015021-pol2qm74	1461	1	post	post	JJ
cord-015021-pol2qm74	1461	2	-	-	JJ
cord-015021-pol2qm74	1461	3	CLP	clp	JJ
cord-015021-pol2qm74	1461	4	,	,	,
cord-015021-pol2qm74	1461	5	splenic	splenic	JJ
cord-015021-pol2qm74	1461	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	1461	7	from	from	IN
cord-015021-pol2qm74	1461	8	CLP	CLP	NNP
cord-015021-pol2qm74	1461	9	rats	rat	NNS
cord-015021-pol2qm74	1461	10	showed	show	VBD
cord-015021-pol2qm74	1461	11	a	a	DT
cord-015021-pol2qm74	1461	12	substantial	substantial	JJ
cord-015021-pol2qm74	1461	13	increase	increase	NN
cord-015021-pol2qm74	1461	14	in	in	IN
cord-015021-pol2qm74	1461	15	the	the	DT
cord-015021-pol2qm74	1461	16	synthesis	synthesis	NN
cord-015021-pol2qm74	1461	17	of	of	IN
cord-015021-pol2qm74	1461	18	low	low	JJ
cord-015021-pol2qm74	1461	19	molecular	molecular	JJ
cord-015021-pol2qm74	1461	20	weight	weight	NN
cord-015021-pol2qm74	1461	21	(	(	-LRB-
cord-015021-pol2qm74	1461	22	<	<	XX
cord-015021-pol2qm74	1461	23	40	40	CD
cord-015021-pol2qm74	1461	24	kD	kd	JJ
cord-015021-pol2qm74	1461	25	)	)	-RRB-
cord-015021-pol2qm74	1461	26	proteins	protein	NNS
cord-015021-pol2qm74	1461	27	,	,	,
cord-015021-pol2qm74	1461	28	when	when	WRB
cord-015021-pol2qm74	1461	29	compared	compare	VBN
cord-015021-pol2qm74	1461	30	to	to	IN
cord-015021-pol2qm74	1461	31	non	non	JJ
cord-015021-pol2qm74	1461	32	-	-	JJ
cord-015021-pol2qm74	1461	33	septic	septic	JJ
cord-015021-pol2qm74	1461	34	controls	control	NNS
cord-015021-pol2qm74	1461	35	.	.	.
cord-015021-pol2qm74	1462	1	We	-PRON-	PRP
cord-015021-pol2qm74	1462	2	conclude	conclude	VBP
cord-015021-pol2qm74	1462	3	that	that	DT
cord-015021-pol2qm74	1462	4	:	:	:
cord-015021-pol2qm74	1462	5	l	l	LS
cord-015021-pol2qm74	1462	6	)	)	-RRB-
cord-015021-pol2qm74	1462	7	fulminate	fulminate	VBP
cord-015021-pol2qm74	1462	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	1462	9	sepsis	sepsis	NN
cord-015021-pol2qm74	1462	10	induces	induce	VBZ
cord-015021-pol2qm74	1462	11	an	an	DT
cord-015021-pol2qm74	1462	12	early	early	JJ
cord-015021-pol2qm74	1462	13	(	(	-LRB-
cord-015021-pol2qm74	1462	14	3	3	CD
cord-015021-pol2qm74	1462	15	hrs	hrs	NN
cord-015021-pol2qm74	1462	16	.	.	.
cord-015021-pol2qm74	1462	17	)	)	-RRB-
cord-015021-pol2qm74	1463	1	Staining	stain	VBG
cord-015021-pol2qm74	1463	2	with	with	IN
cord-015021-pol2qm74	1463	3	CD14	CD14	NNP
cord-015021-pol2qm74	1463	4	and	and	CC
cord-015021-pol2qm74	1463	5	CD16	CD16	NNP
cord-015021-pol2qm74	1463	6	mAbs	mAbs	NNP
cord-015021-pol2qm74	1463	7	will	will	MD
cord-015021-pol2qm74	1463	8	identify	identify	VB
cord-015021-pol2qm74	1463	9	two	two	CD
cord-015021-pol2qm74	1463	10	monocyte	monocyte	NNP
cord-015021-pol2qm74	1463	11	subpopulations	subpopulation	NNS
cord-015021-pol2qm74	1463	12	in	in	IN
cord-015021-pol2qm74	1463	13	human	human	JJ
cord-015021-pol2qm74	1463	14	blood	blood	NN
cord-015021-pol2qm74	1463	15	:	:	:
cord-015021-pol2qm74	1463	16	A	a	DT
cord-015021-pol2qm74	1463	17	major	major	JJ
cord-015021-pol2qm74	1463	18	population	population	NN
cord-015021-pol2qm74	1463	19	of	of	IN
cord-015021-pol2qm74	1463	20	regular	regular	JJ
cord-015021-pol2qm74	1463	21	monocytes	monocyte	NNS
cord-015021-pol2qm74	1463	22	,	,	,
cord-015021-pol2qm74	1463	23	which	which	WDT
cord-015021-pol2qm74	1463	24	strongly	strongly	RB
cord-015021-pol2qm74	1463	25	expresses	express	VBZ
cord-015021-pol2qm74	1463	26	the	the	DT
cord-015021-pol2qm74	1463	27	CD14	CD14	NNP
cord-015021-pol2qm74	1463	28	antigen	antigen	NN
cord-015021-pol2qm74	1463	29	(	(	-LRB-
cord-015021-pol2qm74	1463	30	CD14++	cd14++	NN
cord-015021-pol2qm74	1463	31	)	)	-RRB-
cord-015021-pol2qm74	1463	32	and	and	CC
cord-015021-pol2qm74	1463	33	a	a	DT
cord-015021-pol2qm74	1463	34	minor	minor	JJ
cord-015021-pol2qm74	1463	35	population	population	NN
cord-015021-pol2qm74	1463	36	with	with	IN
cord-015021-pol2qm74	1463	37	weak	weak	JJ
cord-015021-pol2qm74	1463	38	expression	expression	NN
cord-015021-pol2qm74	1463	39	of	of	IN
cord-015021-pol2qm74	1463	40	CD14	CD14	NNP
cord-015021-pol2qm74	1463	41	and	and	CC
cord-015021-pol2qm74	1463	42	expression	expression	NN
cord-015021-pol2qm74	1463	43	of	of	IN
cord-015021-pol2qm74	1463	44	the	the	DT
cord-015021-pol2qm74	1463	45	CD16	CD16	NNP
cord-015021-pol2qm74	1463	46	antigen	antigen	NN
cord-015021-pol2qm74	1463	47	lCD14+/	lCD14+/	NNS
cord-015021-pol2qm74	1464	1	CD16	CD16	NNP
cord-015021-pol2qm74	1464	2	+	+	CC
cord-015021-pol2qm74	1464	3	cells	cell	NNS
cord-015021-pol2qm74	1464	4	)	)	-RRB-
cord-015021-pol2qm74	1464	5	.	.	.
cord-015021-pol2qm74	1465	1	In	in	IN
cord-015021-pol2qm74	1465	2	healthy	healthy	JJ
cord-015021-pol2qm74	1465	3	control	control	NN
cord-015021-pol2qm74	1465	4	donors(n=35	donors(n=35	IN
cord-015021-pol2qm74	1465	5	)	)	-RRB-
cord-015021-pol2qm74	1465	6	the	the	DT
cord-015021-pol2qm74	1465	7	latter	latter	JJ
cord-015021-pol2qm74	1465	8	cells	cell	NNS
cord-015021-pol2qm74	1465	9	account	account	VBP
cord-015021-pol2qm74	1465	10	for	for	IN
cord-015021-pol2qm74	1465	11	45	45	CD
cord-015021-pol2qm74	1465	12	+	+	SYM
cord-015021-pol2qm74	1465	13	22	22	CD
cord-015021-pol2qm74	1465	14	cells	cell	NNS
cord-015021-pol2qm74	1465	15	/	/	SYM
cord-015021-pol2qm74	1465	16	mm	mm	NNP
cord-015021-pol2qm74	1465	17	3	3	CD
cord-015021-pol2qm74	1465	18	and	and	CC
cord-015021-pol2qm74	1465	19	9%+5	9%+5	CD
cord-015021-pol2qm74	1465	20	%	%	NN
cord-015021-pol2qm74	1465	21	of	of	IN
cord-015021-pol2qm74	1465	22	the	the	DT
cord-015021-pol2qm74	1465	23	monocytes	monocyte	NNS
cord-015021-pol2qm74	1465	24	.	.	.
cord-015021-pol2qm74	1466	1	In	in	IN
cord-015021-pol2qm74	1466	2	sepsis	sepsis	NN
cord-015021-pol2qm74	1466	3	patients	patient	NNS
cord-015021-pol2qm74	1466	4	,	,	,
cord-015021-pol2qm74	1466	5	the	the	DT
cord-015021-pol2qm74	1466	6	CD]4+/CD16	cd]4+/cd16	NN
cord-015021-pol2qm74	1466	7	+	+	CC
cord-015021-pol2qm74	1466	8	cells	cell	NNS
cord-015021-pol2qm74	1466	9	can	can	MD
cord-015021-pol2qm74	1466	10	become	become	VB
cord-015021-pol2qm74	1466	11	a	a	DT
cord-015021-pol2qm74	1466	12	major	major	JJ
cord-015021-pol2qm74	1466	13	population	population	NN
cord-015021-pol2qm74	1466	14	with	with	IN
cord-015021-pol2qm74	1466	15	more	more	JJR
cord-015021-pol2qm74	1466	16	than	than	IN
cord-015021-pol2qm74	1466	17	50	50	CD
cord-015021-pol2qm74	1466	18	%	%	NN
cord-015021-pol2qm74	1466	19	of	of	IN
cord-015021-pol2qm74	1466	20	all	all	DT
cord-015021-pol2qm74	1466	21	monocytes	monocyte	NNS
cord-015021-pol2qm74	1466	22	in	in	IN
cord-015021-pol2qm74	1466	23	3	3	CD
cord-015021-pol2qm74	1466	24	of	of	IN
cord-015021-pol2qm74	1466	25	18	18	CD
cord-015021-pol2qm74	1466	26	patients	patient	NNS
cord-015021-pol2qm74	1466	27	and	and	CC
cord-015021-pol2qm74	1466	28	with	with	IN
cord-015021-pol2qm74	1466	29	more	more	JJR
cord-015021-pol2qm74	1466	30	than	than	IN
cord-015021-pol2qm74	1466	31	500	500	CD
cord-015021-pol2qm74	1466	32	cells	cell	NNS
cord-015021-pol2qm74	1466	33	/	/	SYM
cord-015021-pol2qm74	1466	34	mm	mm	NN
cord-015021-pol2qm74	1466	35	3	3	CD
cord-015021-pol2qm74	1466	36	in	in	IN
cord-015021-pol2qm74	1466	37	4	4	CD
cord-015021-pol2qm74	1466	38	of	of	IN
cord-015021-pol2qm74	1466	39	18	18	CD
cord-015021-pol2qm74	1466	40	cases	case	NNS
cord-015021-pol2qm74	1466	41	.	.	.
cord-015021-pol2qm74	1467	1	There	there	EX
cord-015021-pol2qm74	1467	2	was	be	VBD
cord-015021-pol2qm74	1467	3	no	no	DT
cord-015021-pol2qm74	1467	4	correlation	correlation	NN
cord-015021-pol2qm74	1467	5	of	of	IN
cord-015021-pol2qm74	1467	6	CD14+/	cd14+/	NN
cord-015021-pol2qm74	1468	1	CD16	CD16	NNP
cord-015021-pol2qm74	1468	2	+	+	CC
cord-015021-pol2qm74	1468	3	cells	cell	NNS
cord-015021-pol2qm74	1468	4	to	to	IN
cord-015021-pol2qm74	1468	5	any	any	DT
cord-015021-pol2qm74	1468	6	clinical	clinical	JJ
cord-015021-pol2qm74	1468	7	parameter	parameter	NN
cord-015021-pol2qm74	1468	8	except	except	IN
cord-015021-pol2qm74	1468	9	for	for	IN
cord-015021-pol2qm74	1468	10	CD14+/CD16	cd14+/cd16	NN
cord-015021-pol2qm74	1468	11	+	+	CC
cord-015021-pol2qm74	1468	12	percentage	percentage	NN
cord-015021-pol2qm74	1468	13	and	and	CC
cord-015021-pol2qm74	1468	14	body	body	NN
cord-015021-pol2qm74	1468	15	temperature	temperature	NN
cord-015021-pol2qm74	1468	16	(	(	-LRB-
cord-015021-pol2qm74	1468	17	p=	p=	NNP
cord-015021-pol2qm74	1468	18	0.013	0.013	CD
cord-015021-pol2qm74	1468	19	)	)	-RRB-
cord-015021-pol2qm74	1468	20	.	.	.
cord-015021-pol2qm74	1469	1	The	the	DT
cord-015021-pol2qm74	1469	2	CD14++	cd14++	CD
cord-015021-pol2qm74	1469	3	monocytes	monocyte	NNS
cord-015021-pol2qm74	1469	4	showed	show	VBD
cord-015021-pol2qm74	1469	5	a	a	DT
cord-015021-pol2qm74	1469	6	substanttial	substanttial	JJ
cord-015021-pol2qm74	1469	7	decrease	decrease	NN
cord-015021-pol2qm74	1469	8	in	in	IN
cord-015021-pol2qm74	1469	9	CD14	CD14	NNP
cord-015021-pol2qm74	1469	10	antigen	antigen	NN
cord-015021-pol2qm74	1469	11	density	density	NN
cord-015021-pol2qm74	1469	12	in	in	IN
cord-015021-pol2qm74	1469	13	9	9	CD
cord-015021-pol2qm74	1469	14	of	of	IN
cord-015021-pol2qm74	1469	15	11	11	CD
cord-015021-pol2qm74	1469	16	patients	patient	NNS
cord-015021-pol2qm74	1469	17	.	.	.
cord-015021-pol2qm74	1470	1	Three	three	CD
cord-015021-pol2qm74	1470	2	-	-	HYPH
cord-015021-pol2qm74	1470	3	color	color	NN
cord-015021-pol2qm74	1470	4	-	-	HYPH
cord-015021-pol2qm74	1470	5	IF	if	NN
cord-015021-pol2qm74	1470	6	shows	show	VBZ
cord-015021-pol2qm74	1470	7	that	that	IN
cord-015021-pol2qm74	1470	8	the	the	DT
cord-015021-pol2qm74	1470	9	CD14+/	CD14+/	NNP
cord-015021-pol2qm74	1470	10	CD16	CD16	NNP
cord-015021-pol2qm74	1470	11	+	+	CC
cord-015021-pol2qm74	1470	12	cells	cell	NNS
cord-015021-pol2qm74	1470	13	in	in	IN
cord-015021-pol2qm74	1470	14	sepsis	sepsis	NN
cord-015021-pol2qm74	1470	15	patients	patient	NNS
cord-015021-pol2qm74	1470	16	when	when	WRB
cord-015021-pol2qm74	1470	17	compared	compare	VBN
cord-015021-pol2qm74	1470	18	with	with	IN
cord-015021-pol2qm74	1471	1	the	the	DT
cord-015021-pol2qm74	1471	2	CD14++	cd14++	CD
cord-015021-pol2qm74	1471	3	monocytes	monocyte	VBZ
cord-015021-pol2qm74	1471	4	exhibit	exhibit	VBP
cord-015021-pol2qm74	1471	5	a	a	DT
cord-015021-pol2qm74	1471	6	higher	high	JJR
cord-015021-pol2qm74	1471	7	level	level	NN
cord-015021-pol2qm74	1471	8	of	of	IN
cord-015021-pol2qm74	1471	9	class	class	NN
cord-015021-pol2qm74	1471	10	II	II	NNP
cord-015021-pol2qm74	1471	11	antigen	antigen	NN
cord-015021-pol2qm74	1471	12	and	and	CC
cord-015021-pol2qm74	1471	13	a	a	DT
cord-015021-pol2qm74	1471	14	lower	low	JJR
cord-015021-pol2qm74	1471	15	level	level	NN
cord-015021-pol2qm74	1471	16	of	of	IN
cord-015021-pol2qm74	1471	17	CDIIb	CDIIb	NNS
cord-015021-pol2qm74	1471	18	and	and	CC
cord-015021-pol2qm74	1471	19	CD33	CD33	NNP
cord-015021-pol2qm74	1471	20	antigens	antigen	NNS
cord-015021-pol2qm74	1471	21	,	,	,
cord-015021-pol2qm74	1471	22	consistent	consistent	JJ
cord-015021-pol2qm74	1471	23	with	with	IN
cord-015021-pol2qm74	1471	24	a	a	DT
cord-015021-pol2qm74	1471	25	more	more	RBR
cord-015021-pol2qm74	1471	26	mature	mature	JJ
cord-015021-pol2qm74	1471	27	nature	nature	NN
cord-015021-pol2qm74	1471	28	of	of	IN
cord-015021-pol2qm74	1471	29	the	the	DT
cord-015021-pol2qm74	1471	30	CD14+/CD16	cd14+/cd16	NN
cord-015021-pol2qm74	1471	31	+	+	SYM
cord-015021-pol2qm74	1471	32	cells	cell	NNS
cord-015021-pol2qm74	1471	33	.	.	.
cord-015021-pol2qm74	1472	1	Levels	level	NNS
cord-015021-pol2qm74	1472	2	of	of	IN
cord-015021-pol2qm74	1472	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	1472	4	were	be	VBD
cord-015021-pol2qm74	1472	5	increased	increase	VBN
cord-015021-pol2qm74	1472	6	in	in	IN
cord-015021-pol2qm74	1472	7	sepsis	sepsis	NN
cord-015021-pol2qm74	1472	8	patients	patient	NNS
cord-015021-pol2qm74	1472	9	:	:	:
cord-015021-pol2qm74	1472	10	3	3	CD
cord-015021-pol2qm74	1472	11	of	of	IN
cord-015021-pol2qm74	1472	12	5	5	CD
cord-015021-pol2qm74	1472	13	patients	patient	NNS
cord-015021-pol2qm74	1472	14	with	with	IN
cord-015021-pol2qm74	1472	15	high	high	JJ
cord-015021-pol2qm74	1472	16	numbers	number	NNS
cord-015021-pol2qm74	1472	17	of	of	IN
cord-015021-pol2qm74	1472	18	CDI4+/CD16	cdi4+/cd16	NN
cord-015021-pol2qm74	1472	19	+	+	CC
cord-015021-pol2qm74	1472	20	cells	cell	NNS
cord-015021-pol2qm74	1472	21	(	(	-LRB-
cord-015021-pol2qm74	1472	22	200	200	CD
cord-015021-pol2qm74	1472	23	/	/	SYM
cord-015021-pol2qm74	1472	24	mm	mm	NN
cord-015021-pol2qm74	1472	25	3	3	CD
cord-015021-pol2qm74	1472	26	)	)	-RRB-
cord-015021-pol2qm74	1472	27	had	have	VBD
cord-015021-pol2qm74	1472	28	high	high	JJ
cord-015021-pol2qm74	1472	29	levels	level	NNS
cord-015021-pol2qm74	1472	30	of	of	IN
cord-015021-pol2qm74	1472	31	IL-6	IL-6	NNP
cord-015021-pol2qm74	1472	32	(	(	-LRB-
cord-015021-pol2qm74	1472	33	250U	250u	CD
cord-015021-pol2qm74	1472	34	/	/	SYM
cord-015021-pol2qm74	1472	35	ml	ml	NN
cord-015021-pol2qm74	1472	36	)	)	-RRB-
cord-015021-pol2qm74	1472	37	.	.	.
cord-015021-pol2qm74	1473	1	These	these	DT
cord-015021-pol2qm74	1473	2	data	datum	NNS
cord-015021-pol2qm74	1473	3	suggest	suggest	VBP
cord-015021-pol2qm74	1473	4	that	that	IN
cord-015021-pol2qm74	1473	5	septicemia	septicemia	NN
cord-015021-pol2qm74	1473	6	may	may	MD
cord-015021-pol2qm74	1473	7	lead	lead	VB
cord-015021-pol2qm74	1473	8	to	to	IN
cord-015021-pol2qm74	1473	9	substantial	substantial	JJ
cord-015021-pol2qm74	1473	10	changes	change	NNS
cord-015021-pol2qm74	1473	11	in	in	IN
cord-015021-pol2qm74	1473	12	blood	blood	NN
cord-015021-pol2qm74	1473	13	monocyte	monocyte	NNP
cord-015021-pol2qm74	1473	14	composition	composition	NN
cord-015021-pol2qm74	1473	15	and	and	CC
cord-015021-pol2qm74	1473	16	this	this	DT
cord-015021-pol2qm74	1473	17	may	may	MD
cord-015021-pol2qm74	1473	18	be	be	VB
cord-015021-pol2qm74	1473	19	related	relate	VBN
cord-015021-pol2qm74	1473	20	to	to	IN
cord-015021-pol2qm74	1473	21	elevated	elevated	JJ
cord-015021-pol2qm74	1473	22	levels	level	NNS
cord-015021-pol2qm74	1473	23	of	of	IN
cord-015021-pol2qm74	1473	24	cytokines	cytokine	NNS
cord-015021-pol2qm74	1473	25	such	such	JJ
cord-015021-pol2qm74	1473	26	as	as	IN
cord-015021-pol2qm74	1473	27	IL-6	IL-6	NNP
cord-015021-pol2qm74	1473	28	.	.	.
cord-015021-pol2qm74	1474	1	Human	human	JJ
cord-015021-pol2qm74	1474	2	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	1474	3	macrophages	macrophage	NNS
cord-015021-pol2qm74	1474	4	were	be	VBD
cord-015021-pol2qm74	1474	5	exposed	expose	VBN
cord-015021-pol2qm74	1474	6	to	to	IN
cord-015021-pol2qm74	1474	7	increasing	increase	VBG
cord-015021-pol2qm74	1474	8	doses	dose	NNS
cord-015021-pol2qm74	1474	9	of	of	IN
cord-015021-pol2qm74	1474	10	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-015021-pol2qm74	1474	11	(	(	-LRB-
cord-015021-pol2qm74	1474	12	LPS	LPS	NNP
cord-015021-pol2qm74	1474	13	)	)	-RRB-
cord-015021-pol2qm74	1474	14	or	or	CC
cord-015021-pol2qm74	1474	15	a	a	DT
cord-015021-pol2qm74	1474	16	synthetic	synthetic	JJ
cord-015021-pol2qm74	1474	17	Lipid	Lipid	NNP
cord-015021-pol2qm74	1474	18	A	a	DT
cord-015021-pol2qm74	1474	19	analogue	analogue	NN
cord-015021-pol2qm74	1474	20	(	(	-LRB-
cord-015021-pol2qm74	1474	21	MRL	MRL	NNP
cord-015021-pol2qm74	1474	22	953	953	CD
cord-015021-pol2qm74	1474	23	)	)	-RRB-
cord-015021-pol2qm74	1474	24	and	and	CC
cord-015021-pol2qm74	1474	25	production	production	NN
cord-015021-pol2qm74	1474	26	of	of	IN
cord-015021-pol2qm74	1474	27	the	the	DT
cord-015021-pol2qm74	1474	28	cytokines	cytokine	NNS
cord-015021-pol2qm74	1474	29	IL	IL	NNP
cord-015021-pol2qm74	1474	30	-	-	HYPH
cord-015021-pol2qm74	1474	31	lb	lb	NNP
cord-015021-pol2qm74	1474	32	,	,	,
cord-015021-pol2qm74	1474	33	iL-6	iL-6	NNP
cord-015021-pol2qm74	1474	34	,	,	,
cord-015021-pol2qm74	1474	35	TNF	TNF	NNP
cord-015021-pol2qm74	1474	36	-	-	:
cord-015021-pol2qm74	1474	37	a	a	NNP
cord-015021-pol2qm74	1474	38	and	and	CC
cord-015021-pol2qm74	1474	39	G	G	NNP
cord-015021-pol2qm74	1474	40	-	-	HYPH
cord-015021-pol2qm74	1474	41	CSF	CSF	NNP
cord-015021-pol2qm74	1474	42	was	be	VBD
cord-015021-pol2qm74	1474	43	assessed	assess	VBN
cord-015021-pol2qm74	1474	44	at	at	IN
cord-015021-pol2qm74	1474	45	the	the	DT
cord-015021-pol2qm74	1474	46	protein	protein	NN
cord-015021-pol2qm74	1474	47	-	-	:
cord-015021-pol2qm74	1474	48	and	and	CC
cord-015021-pol2qm74	1474	49	mRNAlevel	mRNAlevel	NNS
cord-015021-pol2qm74	1474	50	.	.	.
cord-015021-pol2qm74	1475	1	Cells	cell	NNS
cord-015021-pol2qm74	1475	2	were	be	VBD
cord-015021-pol2qm74	1475	3	also	also	RB
cord-015021-pol2qm74	1475	4	stimulated	stimulate	VBN
cord-015021-pol2qm74	1475	5	with	with	IN
cord-015021-pol2qm74	1475	6	low	low	JJ
cord-015021-pol2qm74	1475	7	doses	dose	NNS
cord-015021-pol2qm74	1475	8	of	of	IN
cord-015021-pol2qm74	1475	9	LPS	LPS	NNP
cord-015021-pol2qm74	1475	10	and	and	CC
cord-015021-pol2qm74	1475	11	MRL	MRL	NNP
cord-015021-pol2qm74	1475	12	953	953	CD
cord-015021-pol2qm74	1475	13	to	to	TO
cord-015021-pol2qm74	1475	14	study	study	VB
cord-015021-pol2qm74	1475	15	their	-PRON-	PRP$
cord-015021-pol2qm74	1475	16	"	"	``
cord-015021-pol2qm74	1475	17	adaptation	adaptation	NN
cord-015021-pol2qm74	1475	18	"	"	''
cord-015021-pol2qm74	1475	19	to	to	IN
cord-015021-pol2qm74	1475	20	a	a	DT
cord-015021-pol2qm74	1475	21	secondary	secondary	JJ
cord-015021-pol2qm74	1475	22	challenge	challenge	NN
cord-015021-pol2qm74	1475	23	with	with	IN
cord-015021-pol2qm74	1475	24	high	high	JJ
cord-015021-pol2qm74	1475	25	doses	dose	NNS
cord-015021-pol2qm74	1475	26	of	of	IN
cord-015021-pol2qm74	1475	27	LPS	lp	NNS
cord-015021-pol2qm74	1475	28	.	.	.
cord-015021-pol2qm74	1476	1	TNF	TNF	NNP
cord-015021-pol2qm74	1476	2	-	-	:
cord-015021-pol2qm74	1476	3	a	a	DT
cord-015021-pol2qm74	1476	4	production	production	NN
cord-015021-pol2qm74	1476	5	after	after	IN
cord-015021-pol2qm74	1476	6	stimulation	stimulation	NN
cord-015021-pol2qm74	1476	7	with	with	IN
cord-015021-pol2qm74	1476	8	LPS	LPS	NNP
cord-015021-pol2qm74	1476	9	could	could	MD
cord-015021-pol2qm74	1476	10	be	be	VB
cord-015021-pol2qm74	1476	11	almost	almost	RB
cord-015021-pol2qm74	1476	12	completely	completely	RB
cord-015021-pol2qm74	1476	13	relieved	relieve	VBN
cord-015021-pol2qm74	1476	14	by	by	IN
cord-015021-pol2qm74	1476	15	preincubation	preincubation	NN
cord-015021-pol2qm74	1476	16	of	of	IN
cord-015021-pol2qm74	1476	17	cells	cell	NNS
cord-015021-pol2qm74	1476	18	with	with	IN
cord-015021-pol2qm74	1476	19	low	low	JJ
cord-015021-pol2qm74	1476	20	doses	dose	NNS
cord-015021-pol2qm74	1476	21	of	of	IN
cord-015021-pol2qm74	1476	22	LPS	LPS	NNP
cord-015021-pol2qm74	1476	23	and	and	CC
cord-015021-pol2qm74	1476	24	similarly	similarly	RB
cord-015021-pol2qm74	1476	25	,	,	,
cord-015021-pol2qm74	1476	26	IL-6	IL-6	NNP
cord-015021-pol2qm74	1476	27	production	production	NN
cord-015021-pol2qm74	1476	28	was	be	VBD
cord-015021-pol2qm74	1476	29	suppressed	suppress	VBN
cord-015021-pol2qm74	1476	30	.	.	.
cord-015021-pol2qm74	1477	1	Surprisingly	surprisingly	RB
cord-015021-pol2qm74	1477	2	,	,	,
cord-015021-pol2qm74	1477	3	however	however	RB
cord-015021-pol2qm74	1477	4	,	,	,
cord-015021-pol2qm74	1477	5	"	"	``
cord-015021-pol2qm74	1477	6	adapted	adapt	VBN
cord-015021-pol2qm74	1477	7	"	"	''
cord-015021-pol2qm74	1477	8	cells	cell	NNS
cord-015021-pol2qm74	1477	9	were	be	VBD
cord-015021-pol2qm74	1477	10	able	able	JJ
cord-015021-pol2qm74	1477	11	to	to	TO
cord-015021-pol2qm74	1477	12	synthesize	synthesize	VB
cord-015021-pol2qm74	1477	13	even	even	RB
cord-015021-pol2qm74	1477	14	larger	large	JJR
cord-015021-pol2qm74	1477	15	quantities	quantity	NNS
cord-015021-pol2qm74	1477	16	of	of	IN
cord-015021-pol2qm74	1477	17	of	of	IN
cord-015021-pol2qm74	1477	18	G	G	NNP
cord-015021-pol2qm74	1477	19	-	-	HYPH
cord-015021-pol2qm74	1477	20	CSF	CSF	NNP
cord-015021-pol2qm74	1477	21	and	and	CC
cord-015021-pol2qm74	1477	22	IL	IL	NNP
cord-015021-pol2qm74	1477	23	-	-	HYPH
cord-015021-pol2qm74	1477	24	lb	lb	NNP
cord-015021-pol2qm74	1477	25	when	when	WRB
cord-015021-pol2qm74	1477	26	exposed	expose	VBN
cord-015021-pol2qm74	1477	27	to	to	IN
cord-015021-pol2qm74	1477	28	a	a	DT
cord-015021-pol2qm74	1477	29	secondary	secondary	JJ
cord-015021-pol2qm74	1477	30	LPS	LPS	NNP
cord-015021-pol2qm74	1477	31	challenge	challenge	NN
cord-015021-pol2qm74	1477	32	.	.	.
cord-015021-pol2qm74	1478	1	The	the	DT
cord-015021-pol2qm74	1478	2	changes	change	NNS
cord-015021-pol2qm74	1478	3	in	in	IN
cord-015021-pol2qm74	1478	4	TNF	TNF	NNP
cord-015021-pol2qm74	1478	5	-	-	HYPH
cord-015021-pol2qm74	1478	6	a	a	NNP
cord-015021-pol2qm74	1478	7	,	,	,
cord-015021-pol2qm74	1478	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	1478	9	and	and	CC
cord-015021-pol2qm74	1478	10	G	G	NNP
cord-015021-pol2qm74	1478	11	-	-	HYPH
cord-015021-pol2qm74	1478	12	CSF	CSF	NNP
cord-015021-pol2qm74	1478	13	protein	protein	NN
cord-015021-pol2qm74	1478	14	synthesis	synthesis	NN
cord-015021-pol2qm74	1478	15	could	could	MD
cord-015021-pol2qm74	1478	16	a	a	DT
cord-015021-pol2qm74	1478	17	/	/	SYM
cord-015021-pol2qm74	1478	18	so	so	RB
cord-015021-pol2qm74	1478	19	be	be	VB
cord-015021-pol2qm74	1478	20	detected	detect	VBN
cord-015021-pol2qm74	1478	21	on	on	IN
cord-015021-pol2qm74	1478	22	the	the	DT
cord-015021-pol2qm74	1478	23	mRNA	mRNA	NNP
cord-015021-pol2qm74	1478	24	level	level	NN
cord-015021-pol2qm74	1478	25	,	,	,
cord-015021-pol2qm74	1478	26	whereas	whereas	IN
cord-015021-pol2qm74	1478	27	transcript	transcript	NN
cord-015021-pol2qm74	1478	28	levels	level	NNS
cord-015021-pol2qm74	1478	29	for	for	IN
cord-015021-pol2qm74	1478	30	IL	IL	NNP
cord-015021-pol2qm74	1478	31	-	-	HYPH
cord-015021-pol2qm74	1478	32	lb	lb	NN
cord-015021-pol2qm74	1478	33	remained	remain	VBD
cord-015021-pol2qm74	1478	34	unaltered	unaltered	JJ
cord-015021-pol2qm74	1478	35	as	as	IN
cord-015021-pol2qm74	1478	36	assessed	assess	VBN
cord-015021-pol2qm74	1478	37	by	by	IN
cord-015021-pol2qm74	1478	38	Northern	northern	JJ
cord-015021-pol2qm74	1478	39	blot	blot	NN
cord-015021-pol2qm74	1478	40	analysis	analysis	NN
cord-015021-pol2qm74	1478	41	.	.	.
cord-015021-pol2qm74	1479	1	High	high	JJ
cord-015021-pol2qm74	1479	2	doses	dose	NNS
cord-015021-pol2qm74	1479	3	of	of	IN
cord-015021-pol2qm74	1479	4	the	the	DT
cord-015021-pol2qm74	1479	5	synthetic	synthetic	JJ
cord-015021-pol2qm74	1479	6	lipid	lipid	NN
cord-015021-pol2qm74	1480	1	A	a	DT
cord-015021-pol2qm74	1480	2	analogue	analogue	NN
cord-015021-pol2qm74	1480	3	MRL	MRL	NNP
cord-015021-pol2qm74	1480	4	953	953	CD
cord-015021-pol2qm74	1480	5	were	be	VBD
cord-015021-pol2qm74	1480	6	also	also	RB
cord-015021-pol2qm74	1480	7	able	able	JJ
cord-015021-pol2qm74	1480	8	to	to	TO
cord-015021-pol2qm74	1480	9	"	"	``
cord-015021-pol2qm74	1480	10	adapt	adapt	VB
cord-015021-pol2qm74	1480	11	"	"	''
cord-015021-pol2qm74	1480	12	macrophages	macrophage	NNS
cord-015021-pol2qm74	1480	13	for	for	IN
cord-015021-pol2qm74	1480	14	a	a	DT
cord-015021-pol2qm74	1480	15	secondary	secondary	JJ
cord-015021-pol2qm74	1480	16	LPS	LPS	NNP
cord-015021-pol2qm74	1480	17	challenge	challenge	NN
cord-015021-pol2qm74	1480	18	by	by	IN
cord-015021-pol2qm74	1480	19	downregulating	downregulate	VBG
cord-015021-pol2qm74	1480	20	TNFa	TNFa	NNP
cord-015021-pol2qm74	1480	21	-	-	:
cord-015021-pol2qm74	1480	22	and	and	CC
cord-015021-pol2qm74	1480	23	IL-6-production	il-6-production	NN
cord-015021-pol2qm74	1480	24	,	,	,
cord-015021-pol2qm74	1480	25	while	while	IN
cord-015021-pol2qm74	1480	26	priming	prime	VBG
cord-015021-pol2qm74	1480	27	secretion	secretion	NN
cord-015021-pol2qm74	1480	28	of	of	IN
cord-015021-pol2qm74	1480	29	G	G	NNP
cord-015021-pol2qm74	1480	30	-	-	HYPH
cord-015021-pol2qm74	1480	31	CSFand	CSFand	NNP
cord-015021-pol2qm74	1480	32	IL	IL	NNP
cord-015021-pol2qm74	1480	33	-	-	HYPH
cord-015021-pol2qm74	1480	34	lb	lb	NNP
cord-015021-pol2qm74	1480	35	as	as	RB
cord-015021-pol2qm74	1480	36	well	well	RB
cord-015021-pol2qm74	1480	37	.	.	.
cord-015021-pol2qm74	1481	1	Taken	take	VBN
cord-015021-pol2qm74	1481	2	together	together	RB
cord-015021-pol2qm74	1481	3	,	,	,
cord-015021-pol2qm74	1481	4	here	here	RB
cord-015021-pol2qm74	1481	5	we	-PRON-	PRP
cord-015021-pol2qm74	1481	6	describe	describe	VBP
cord-015021-pol2qm74	1481	7	for	for	IN
cord-015021-pol2qm74	1481	8	the	the	DT
cord-015021-pol2qm74	1481	9	first	first	JJ
cord-015021-pol2qm74	1481	10	time	time	NN
cord-015021-pol2qm74	1481	11	the	the	DT
cord-015021-pol2qm74	1481	12	discordant	discordant	JJ
cord-015021-pol2qm74	1481	13	adaptation	adaptation	NN
cord-015021-pol2qm74	1481	14	of	of	IN
cord-015021-pol2qm74	1481	15	human	human	JJ
cord-015021-pol2qm74	1481	16	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	1481	17	macrophages	macrophage	NNS
cord-015021-pol2qm74	1481	18	to	to	IN
cord-015021-pol2qm74	1481	19	a	a	DT
cord-015021-pol2qm74	1481	20	secondary	secondary	JJ
cord-015021-pol2qm74	1481	21	LPS	LPS	NNP
cord-015021-pol2qm74	1481	22	stimulus	stimulus	NN
cord-015021-pol2qm74	1481	23	in	in	IN
cord-015021-pol2qm74	1481	24	vitro	vitro	FW
cord-015021-pol2qm74	1481	25	.	.	.
cord-015021-pol2qm74	1482	1	These	these	DT
cord-015021-pol2qm74	1482	2	findings	finding	NNS
cord-015021-pol2qm74	1482	3	appear	appear	VBP
cord-015021-pol2qm74	1482	4	to	to	TO
cord-015021-pol2qm74	1482	5	bear	bear	VB
cord-015021-pol2qm74	1482	6	ramifications	ramification	NNS
cord-015021-pol2qm74	1482	7	for	for	IN
cord-015021-pol2qm74	1482	8	the	the	DT
cord-015021-pol2qm74	1482	9	in	in	IN
cord-015021-pol2qm74	1482	10	-	-	HYPH
cord-015021-pol2qm74	1482	11	vivo	vivo	NN
cord-015021-pol2qm74	1482	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1482	13	response	response	NN
cord-015021-pol2qm74	1482	14	during	during	IN
cord-015021-pol2qm74	1482	15	inflammation	inflammation	NN
cord-015021-pol2qm74	1482	16	and	and	CC
cord-015021-pol2qm74	1482	17	gramnegative	gramnegative	NN
cord-015021-pol2qm74	1482	18	septicemia	septicemia	NN
cord-015021-pol2qm74	1482	19	.	.	.
cord-015021-pol2qm74	1483	1	Shock	shock	NN
cord-015021-pol2qm74	1483	2	states	state	NNS
cord-015021-pol2qm74	1483	3	with	with	IN
cord-015021-pol2qm74	1483	4	inadequate	inadequate	JJ
cord-015021-pol2qm74	1483	5	cellular	cellular	JJ
cord-015021-pol2qm74	1483	6	oxygen	oxygen	NN
cord-015021-pol2qm74	1483	7	delivery	delivery	NN
cord-015021-pol2qm74	1483	8	may	may	MD
cord-015021-pol2qm74	1483	9	contribute	contribute	VB
cord-015021-pol2qm74	1483	10	to	to	IN
cord-015021-pol2qm74	1483	11	macrophage	macrophage	NN
cord-015021-pol2qm74	1483	12	(	(	-LRB-
cord-015021-pol2qm74	1483	13	MO	MO	NNP
cord-015021-pol2qm74	1483	14	)	)	-RRB-
cord-015021-pol2qm74	1483	15	activation	activation	NN
cord-015021-pol2qm74	1483	16	or	or	CC
cord-015021-pol2qm74	1483	17	dysregulation	dysregulation	NN
cord-015021-pol2qm74	1483	18	.	.	.
cord-015021-pol2qm74	1484	1	In	in	IN
cord-015021-pol2qm74	1484	2	this	this	DT
cord-015021-pol2qm74	1484	3	study	study	NN
cord-015021-pol2qm74	1484	4	we	-PRON-	PRP
cord-015021-pol2qm74	1484	5	compared	compare	VBD
cord-015021-pol2qm74	1484	6	the	the	DT
cord-015021-pol2qm74	1484	7	effect	effect	NN
cord-015021-pol2qm74	1484	8	of	of	IN
cord-015021-pol2qm74	1484	9	transient	transient	JJ
cord-015021-pol2qm74	1484	10	hypoxia	hypoxia	NN
cord-015021-pol2qm74	1484	11	and	and	CC
cord-015021-pol2qm74	1484	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1484	13	pretreatment	pretreatment	NN
cord-015021-pol2qm74	1484	14	(	(	-LRB-
cord-015021-pol2qm74	1484	15	LPS	LPS	NNP
cord-015021-pol2qm74	1484	16	1	1	CD
cord-015021-pol2qm74	1484	17	)	)	-RRB-
cord-015021-pol2qm74	1484	18	on	on	IN
cord-015021-pol2qm74	1484	19	MO	MO	NNP
cord-015021-pol2qm74	1484	20	mediator	mediator	NN
cord-015021-pol2qm74	1484	21	release	release	NN
cord-015021-pol2qm74	1484	22	with	with	IN
cord-015021-pol2qm74	1484	23	a	a	DT
cord-015021-pol2qm74	1484	24	second	second	JJ
cord-015021-pol2qm74	1484	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1484	26	stimulus	stimulus	NN
cord-015021-pol2qm74	1484	27	(	(	-LRB-
cord-015021-pol2qm74	1484	28	LPS2	LPS2	NNP
cord-015021-pol2qm74	1484	29	)	)	-RRB-
cord-015021-pol2qm74	1484	30	.	.	.
cord-015021-pol2qm74	1485	1	Methods	method	NNS
cord-015021-pol2qm74	1485	2	:	:	:
cord-015021-pol2qm74	1486	1	In	in	IN
cord-015021-pol2qm74	1486	2	vitro	vitro	FW
cord-015021-pol2qm74	1486	3	cultures	culture	NNS
cord-015021-pol2qm74	1486	4	of	of	IN
cord-015021-pol2qm74	1486	5	marine	marine	JJ
cord-015021-pol2qm74	1486	6	peritoneal	peritoneal	NN
cord-015021-pol2qm74	1486	7	exudate	exudate	NNP
cord-015021-pol2qm74	1486	8	MO	MO	NNP
cord-015021-pol2qm74	1486	9	were	be	VBD
cord-015021-pol2qm74	1486	10	exposed	expose	VBN
cord-015021-pol2qm74	1486	11	to	to	IN
cord-015021-pol2qm74	1486	12	2	2	CD
cord-015021-pol2qm74	1486	13	hr	hr	NN
cord-015021-pol2qm74	1486	14	.	.	.
cord-015021-pol2qm74	1487	1	of	of	IN
cord-015021-pol2qm74	1487	2	hypoxic	hypoxic	JJ
cord-015021-pol2qm74	1487	3	or	or	CC
cord-015021-pol2qm74	1487	4	normoxic	normoxic	JJ
cord-015021-pol2qm74	1487	5	conditions	condition	NNS
cord-015021-pol2qm74	1487	6	,	,	,
cord-015021-pol2qm74	1487	7	then	then	RB
cord-015021-pol2qm74	1487	8	incubated	incubate	VBD
cord-015021-pol2qm74	1487	9	22	22	CD
cord-015021-pol2qm74	1487	10	hr	hr	NN
cord-015021-pol2qm74	1487	11	under	under	IN
cord-015021-pol2qm74	1487	12	identical	identical	JJ
cord-015021-pol2qm74	1487	13	normoxic	normoxic	JJ
cord-015021-pol2qm74	1487	14	conditions	condition	NNS
cord-015021-pol2qm74	1487	15	_	_	NNP
cord-015021-pol2qm74	1488	1	+	+	SYM
cord-015021-pol2qm74	1488	2	10	10	CD
cord-015021-pol2qm74	1488	3	ng	ng	NN
cord-015021-pol2qm74	1488	4	/	/	SYM
cord-015021-pol2qm74	1488	5	ml	ml	NNS
cord-015021-pol2qm74	1488	6	of	of	IN
cord-015021-pol2qm74	1488	7	LPS	LPS	NNP
cord-015021-pol2qm74	1488	8	1	1	CD
cord-015021-pol2qm74	1488	9	pretreatment	pretreatment	NN
cord-015021-pol2qm74	1488	10	.	.	.
cord-015021-pol2qm74	1489	1	During	during	IN
cord-015021-pol2qm74	1489	2	the	the	DT
cord-015021-pol2qm74	1489	3	final	final	JJ
cord-015021-pol2qm74	1489	4	24	24	CD
cord-015021-pol2qm74	1489	5	hours	hour	NNS
cord-015021-pol2qm74	1489	6	all	all	DT
cord-015021-pol2qm74	1489	7	M	m	NN
cord-015021-pol2qm74	1490	1	~l	~l	NNP
cord-015021-pol2qm74	1490	2	were	be	VBD
cord-015021-pol2qm74	1490	3	exposed	expose	VBN
cord-015021-pol2qm74	1490	4	to	to	IN
cord-015021-pol2qm74	1490	5	a	a	DT
cord-015021-pol2qm74	1490	6	range	range	NN
cord-015021-pol2qm74	1490	7	of	of	IN
cord-015021-pol2qm74	1490	8	LPS	LPS	NNP
cord-015021-pol2qm74	1490	9	2	2	CD
cord-015021-pol2qm74	1490	10	concentrations	concentration	NNS
cord-015021-pol2qm74	1490	11	.	.	.
cord-015021-pol2qm74	1491	1	M	M	NNP
cord-015021-pol2qm74	1491	2	~	~	NFP
cord-015021-pol2qm74	1491	3	i	i	PRP
cord-015021-pol2qm74	1491	4	supernatants	supernatant	NNS
cord-015021-pol2qm74	1491	5	were	be	VBD
cord-015021-pol2qm74	1491	6	assayed	assay	VBN
cord-015021-pol2qm74	1491	7	for	for	IN
cord-015021-pol2qm74	1491	8	TNF	TNF	NNP
cord-015021-pol2qm74	1491	9	,	,	,
cord-015021-pol2qm74	1491	10	IL-1	IL-1	NNP
cord-015021-pol2qm74	1491	11	,	,	,
cord-015021-pol2qm74	1491	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	1491	13	,	,	,
cord-015021-pol2qm74	1491	14	PGE2	PGE2	NNP
cord-015021-pol2qm74	1491	15	,	,	,
cord-015021-pol2qm74	1491	16	nitric	nitric	JJ
cord-015021-pol2qm74	1491	17	oxide	oxide	NN
cord-015021-pol2qm74	1491	18	(	(	-LRB-
cord-015021-pol2qm74	1491	19	NO	no	UH
cord-015021-pol2qm74	1491	20	)	)	-RRB-
cord-015021-pol2qm74	1491	21	,	,	,
cord-015021-pol2qm74	1491	22	and	and	CC
cord-015021-pol2qm74	1491	23	superoxide	superoxide	NN
cord-015021-pol2qm74	1491	24	release	release	NN
cord-015021-pol2qm74	1491	25	.	.	.
cord-015021-pol2qm74	1492	1	Results	result	NNS
cord-015021-pol2qm74	1492	2	:	:	:
cord-015021-pol2qm74	1493	1	LPS	lp	NNS
cord-015021-pol2qm74	1493	2	1	1	CD
cord-015021-pol2qm74	1493	3	markedly	markedly	RB
cord-015021-pol2qm74	1493	4	inhibited	inhibit	VBN
cord-015021-pol2qm74	1493	5	MO	MO	NNP
cord-015021-pol2qm74	1493	6	TNF	TNF	NNP
cord-015021-pol2qm74	1493	7	release	release	NN
cord-015021-pol2qm74	1493	8	by	by	IN
cord-015021-pol2qm74	1493	9	LPS	LPS	NNP
cord-015021-pol2qm74	1493	10	2	2	CD
cord-015021-pol2qm74	1493	11	but	but	CC
cord-015021-pol2qm74	1493	12	hypoxia	hypoxia	NN
cord-015021-pol2qm74	1493	13	had	have	VBD
cord-015021-pol2qm74	1493	14	no	no	DT
cord-015021-pol2qm74	1493	15	effect	effect	NN
cord-015021-pol2qm74	1493	16	on	on	IN
cord-015021-pol2qm74	1493	17	LPS	LPS	NNP
cord-015021-pol2qm74	1493	18	2-triggered	2-triggered	CD
cord-015021-pol2qm74	1493	19	TNF	TNF	NNP
cord-015021-pol2qm74	1493	20	release	release	NN
cord-015021-pol2qm74	1493	21	.	.	.
cord-015021-pol2qm74	1494	1	Hypoxia	hypoxia	NN
cord-015021-pol2qm74	1494	2	increased	increase	VBD
cord-015021-pol2qm74	1494	3	MO	MO	NNP
cord-015021-pol2qm74	1494	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	1494	5	production	production	NN
cord-015021-pol2qm74	1494	6	in	in	IN
cord-015021-pol2qm74	1494	7	the	the	DT
cord-015021-pol2qm74	1494	8	absence	absence	NN
cord-015021-pol2qm74	1494	9	of	of	IN
cord-015021-pol2qm74	1494	10	LPS	LPS	NNP
cord-015021-pol2qm74	1494	11	1	1	CD
cord-015021-pol2qm74	1494	12	,	,	,
cord-015021-pol2qm74	1494	13	but	but	CC
cord-015021-pol2qm74	1494	14	inhibited	inhibited	JJ
cord-015021-pol2qm74	1494	15	LPS	LPS	NNP
cord-015021-pol2qm74	1494	16	1	1	CD
cord-015021-pol2qm74	1494	17	augmentation	augmentation	NN
cord-015021-pol2qm74	1494	18	seen	see	VBN
cord-015021-pol2qm74	1494	19	under	under	IN
cord-015021-pol2qm74	1494	20	normoxic	normoxic	JJ
cord-015021-pol2qm74	1494	21	conditions	condition	NNS
cord-015021-pol2qm74	1494	22	.	.	.
cord-015021-pol2qm74	1495	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	1495	2	with	with	IN
cord-015021-pol2qm74	1495	3	LPS	LPS	NNP
cord-015021-pol2qm74	1495	4	1	1	CD
cord-015021-pol2qm74	1495	5	increased	increase	VBD
cord-015021-pol2qm74	1495	6	NO	no	DT
cord-015021-pol2qm74	1495	7	production	production	NN
cord-015021-pol2qm74	1495	8	from	from	IN
cord-015021-pol2qm74	1495	9	LPS	LPS	NNP
cord-015021-pol2qm74	1495	10	2	2	CD
cord-015021-pol2qm74	1495	11	under	under	IN
cord-015021-pol2qm74	1495	12	normoxic	normoxic	JJ
cord-015021-pol2qm74	1495	13	conditions	condition	NNS
cord-015021-pol2qm74	1495	14	,	,	,
cord-015021-pol2qm74	1495	15	but	but	CC
cord-015021-pol2qm74	1495	16	bypoxiainhibited	bypoxiainhibite	VBD
cord-015021-pol2qm74	1495	17	this	this	DT
cord-015021-pol2qm74	1495	18	effect	effect	NN
cord-015021-pol2qm74	1495	19	.	.	.
cord-015021-pol2qm74	1496	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	1496	2	with	with	IN
cord-015021-pol2qm74	1496	3	LPS1	LPS1	NNP
cord-015021-pol2qm74	1496	4	signifcantly	signifcantly	RB
cord-015021-pol2qm74	1496	5	augmented	augment	VBD
cord-015021-pol2qm74	1496	6	MO	MO	NNP
cord-015021-pol2qm74	1496	7	release	release	NN
cord-015021-pol2qm74	1496	8	of	of	IN
cord-015021-pol2qm74	1496	9	IL	IL	NNP
cord-015021-pol2qm74	1496	10	-	-	HYPH
cord-015021-pol2qm74	1496	11	i	i	NNP
cord-015021-pol2qm74	1496	12	and	and	CC
cord-015021-pol2qm74	1496	13	PGE	PGE	NNP
cord-015021-pol2qm74	1496	14	2	2	CD
cord-015021-pol2qm74	1496	15	,	,	,
cord-015021-pol2qm74	1496	16	but	but	CC
cord-015021-pol2qm74	1496	17	hypoxia	hypoxia	NN
cord-015021-pol2qm74	1496	18	had	have	VBD
cord-015021-pol2qm74	1496	19	no	no	DT
cord-015021-pol2qm74	1496	20	significant	significant	JJ
cord-015021-pol2qm74	1496	21	effect	effect	NN
cord-015021-pol2qm74	1496	22	(	(	-LRB-
cord-015021-pol2qm74	1496	23	data	datum	NNS
cord-015021-pol2qm74	1496	24	not	not	RB
cord-015021-pol2qm74	1496	25	shown	show	VBN
cord-015021-pol2qm74	1496	26	)	)	-RRB-
cord-015021-pol2qm74	1497	1	Superoxide	superoxide	NN
cord-015021-pol2qm74	1497	2	production	production	NN
cord-015021-pol2qm74	1497	3	was	be	VBD
cord-015021-pol2qm74	1497	4	increased	increase	VBN
cord-015021-pol2qm74	1497	5	by	by	IN
cord-015021-pol2qm74	1497	6	LPS	LPS	NNP
cord-015021-pol2qm74	1497	7	1	1	CD
cord-015021-pol2qm74	1497	8	under	under	IN
cord-015021-pol2qm74	1497	9	normoxic	normoxic	JJ
cord-015021-pol2qm74	1497	10	conditions	condition	NNS
cord-015021-pol2qm74	1497	11	,	,	,
cord-015021-pol2qm74	1497	12	but	but	CC
cord-015021-pol2qm74	1497	13	hypoxia	hypoxia	NN
cord-015021-pol2qm74	1497	14	significantly	significantly	RB
cord-015021-pol2qm74	1497	15	inhibited	inhibit	VBN
cord-015021-pol2qm74	1497	16	superoxide	superoxide	NN
cord-015021-pol2qm74	1497	17	release	release	NN
cord-015021-pol2qm74	1497	18	(	(	-LRB-
cord-015021-pol2qm74	1497	19	not	not	RB
cord-015021-pol2qm74	1497	20	shown	show	VBN
cord-015021-pol2qm74	1497	21	A.	A.	NNP
cord-015021-pol2qm74	1497	22	Lepape	Lepape	NNP
cord-015021-pol2qm74	1497	23	,	,	,
cord-015021-pol2qm74	1497	24	C.	C.	NNP
cord-015021-pol2qm74	1497	25	Docile	Docile	NNP
cord-015021-pol2qm74	1497	26	,	,	,
cord-015021-pol2qm74	1497	27	F.	F.	NNP
cord-015021-pol2qm74	1497	28	Arpin	Arpin	NNP
cord-015021-pol2qm74	1497	29	,	,	,
cord-015021-pol2qm74	1497	30	M.	M.	NNP
cord-015021-pol2qm74	1497	31	C.	C.	NNP
cord-015021-pol2qm74	1497	32	Gutowski	Gutowski	NNP
cord-015021-pol2qm74	1497	33	,	,	,
cord-015021-pol2qm74	1497	34	V.	V.	NNP
cord-015021-pol2qm74	1497	35	Banssillon	Banssillon	NNP
cord-015021-pol2qm74	1497	36	and	and	CC
cord-015021-pol2qm74	1497	37	J.	J.	NNP
cord-015021-pol2qm74	1497	38	Bienvenu	Bienvenu	NNP
cord-015021-pol2qm74	1497	39	.	.	.
cord-015021-pol2qm74	1498	1	I	-PRON-	PRP
cord-015021-pol2qm74	1498	2	AIM	aim	VBP
cord-015021-pol2qm74	1498	3	OF	of	IN
cord-015021-pol2qm74	1498	4	THE	the	DT
cord-015021-pol2qm74	1498	5	STUDY	study	NN
cord-015021-pol2qm74	1498	6	.	.	.
cord-015021-pol2qm74	1499	1	Increased	increase	VBN
cord-015021-pol2qm74	1499	2	levels	level	NNS
cord-015021-pol2qm74	1499	3	of	of	IN
cord-015021-pol2qm74	1499	4	TNF	TNF	NNP
cord-015021-pol2qm74	1499	5	are	be	VBP
cord-015021-pol2qm74	1499	6	inconsistently	inconsistently	RB
cord-015021-pol2qm74	1499	7	correlated	correlate	VBN
cord-015021-pol2qm74	1499	8	with	with	IN
cord-015021-pol2qm74	1499	9	the	the	DT
cord-015021-pol2qm74	1499	10	severity	severity	NN
cord-015021-pol2qm74	1499	11	of	of	IN
cord-015021-pol2qm74	1499	12	sepsis	sepsis	NN
cord-015021-pol2qm74	1499	13	.	.	.
cord-015021-pol2qm74	1500	1	One	one	CD
cord-015021-pol2qm74	1500	2	possible	possible	JJ
cord-015021-pol2qm74	1500	3	explanation	explanation	NN
cord-015021-pol2qm74	1500	4	is	be	VBZ
cord-015021-pol2qm74	1500	5	a	a	DT
cord-015021-pol2qm74	1500	6	decrease	decrease	NN
cord-015021-pol2qm74	1500	7	ability	ability	NN
cord-015021-pol2qm74	1500	8	of	of	IN
cord-015021-pol2qm74	1500	9	ceils	ceil	NNS
cord-015021-pol2qm74	1500	10	to	to	TO
cord-015021-pol2qm74	1500	11	produce	produce	VB
cord-015021-pol2qm74	1500	12	eytokines	eytokine	NNS
cord-015021-pol2qm74	1500	13	.	.	.
cord-015021-pol2qm74	1501	1	The	the	DT
cord-015021-pol2qm74	1501	2	objectives	objective	NNS
cord-015021-pol2qm74	1501	3	of	of	IN
cord-015021-pol2qm74	1501	4	this	this	DT
cord-015021-pol2qm74	1501	5	study	study	NN
cord-015021-pol2qm74	1501	6	were	be	VBD
cord-015021-pol2qm74	1501	7	m	m	NNP
cord-015021-pol2qm74	1501	8	compare	compare	NN
cord-015021-pol2qm74	1501	9	at	at	IN
cord-015021-pol2qm74	1501	10	different	different	JJ
cord-015021-pol2qm74	1501	11	levels	level	NNS
cord-015021-pol2qm74	1501	12	of	of	IN
cord-015021-pol2qm74	1501	13	of	of	IN
cord-015021-pol2qm74	1501	14	clinical	clinical	JJ
cord-015021-pol2qm74	1501	15	severity	severity	NN
cord-015021-pol2qm74	1501	16	the	the	DT
cord-015021-pol2qm74	1501	17	responsiveness	responsiveness	NN
cord-015021-pol2qm74	1501	18	of	of	IN
cord-015021-pol2qm74	1501	19	cytokine	cytokine	NN
cord-015021-pol2qm74	1501	20	producing	produce	VBG
cord-015021-pol2qm74	1501	21	cells	cell	NNS
cord-015021-pol2qm74	1501	22	.	.	.
cord-015021-pol2qm74	1502	1	This	this	DT
cord-015021-pol2qm74	1502	2	was	be	VBD
cord-015021-pol2qm74	1502	3	evaluated	evaluate	VBN
cord-015021-pol2qm74	1502	4	by	by	IN
cord-015021-pol2qm74	1502	5	the	the	DT
cord-015021-pol2qm74	1502	6	response	response	NN
cord-015021-pol2qm74	1502	7	to	to	IN
cord-015021-pol2qm74	1502	8	a	a	DT
cord-015021-pol2qm74	1502	9	stimulation	stimulation	NN
cord-015021-pol2qm74	1502	10	by	by	IN
cord-015021-pol2qm74	1502	11	LPS	lp	NNS
cord-015021-pol2qm74	1502	12	as	as	RB
cord-015021-pol2qm74	1502	13	well	well	RB
cord-015021-pol2qm74	1502	14	as	as	IN
cord-015021-pol2qm74	1502	15	to	to	IN
cord-015021-pol2qm74	1502	16	the	the	DT
cord-015021-pol2qm74	1502	17	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1502	18	effect	effect	NN
cord-015021-pol2qm74	1502	19	of	of	IN
cord-015021-pol2qm74	1502	20	PTX	PTX	NNP
cord-015021-pol2qm74	1502	21	.	.	.
cord-015021-pol2qm74	1503	1	The	the	DT
cord-015021-pol2qm74	1503	2	technic	technic	NN
cord-015021-pol2qm74	1503	3	used	use	VBN
cord-015021-pol2qm74	1503	4	is	be	VBZ
cord-015021-pol2qm74	1503	5	a	a	DT
cord-015021-pol2qm74	1503	6	whole	whole	JJ
cord-015021-pol2qm74	1503	7	blood	blood	NN
cord-015021-pol2qm74	1503	8	ex	ex	NN
cord-015021-pol2qm74	1503	9	-	-	JJ
cord-015021-pol2qm74	1503	10	vivo	vivo	JJ
cord-015021-pol2qm74	1503	11	model	model	NN
cord-015021-pol2qm74	1503	12	,	,	,
cord-015021-pol2qm74	1503	13	as	as	IN
cord-015021-pol2qm74	1503	14	described	describe	VBN
cord-015021-pol2qm74	1503	15	by	by	IN
cord-015021-pol2qm74	1503	16	DESCH	DESCH	NNP
cord-015021-pol2qm74	1503	17	et	et	FW
cord-015021-pol2qm74	1503	18	al	al	NNP
cord-015021-pol2qm74	1503	19	.	.	.
cord-015021-pol2qm74	1504	1	(	(	-LRB-
cord-015021-pol2qm74	1504	2	1	1	CD
cord-015021-pol2qm74	1504	3	)	)	-RRB-
cord-015021-pol2qm74	1504	4	.	.	.
cord-015021-pol2qm74	1505	1	H	h	NN
cord-015021-pol2qm74	1505	2	MATERIALS	materials	NN
cord-015021-pol2qm74	1505	3	AND	and	CC
cord-015021-pol2qm74	1505	4	METHODS	methods	NN
cord-015021-pol2qm74	1505	5	.	.	.
cord-015021-pol2qm74	1506	1	Different	different	JJ
cord-015021-pol2qm74	1506	2	groups	group	NNS
cord-015021-pol2qm74	1506	3	of	of	IN
cord-015021-pol2qm74	1506	4	ICU	ICU	NNP
cord-015021-pol2qm74	1506	5	patients	patient	NNS
cord-015021-pol2qm74	1506	6	,	,	,
cord-015021-pol2qm74	1506	7	postoperative	postoperative	JJ
cord-015021-pol2qm74	1506	8	(	(	-LRB-
cord-015021-pol2qm74	1506	9	n=12	n=12	NNP
cord-015021-pol2qm74	1506	10	)	)	-RRB-
cord-015021-pol2qm74	1506	11	,	,	,
cord-015021-pol2qm74	1506	12	sepsis	sepsis	NN
cord-015021-pol2qm74	1506	13	(	(	-LRB-
cord-015021-pol2qm74	1506	14	n=12	n=12	NNP
cord-015021-pol2qm74	1506	15	)	)	-RRB-
cord-015021-pol2qm74	1506	16	,	,	,
cord-015021-pol2qm74	1506	17	septick	septick	NNP
cord-015021-pol2qm74	1506	18	shock	shock	NNP
cord-015021-pol2qm74	1506	19	(	(	-LRB-
cord-015021-pol2qm74	1506	20	n=13	n=13	NNP
cord-015021-pol2qm74	1506	21	)	)	-RRB-
cord-015021-pol2qm74	1506	22	,	,	,
cord-015021-pol2qm74	1506	23	and	and	CC
cord-015021-pol2qm74	1506	24	healthy	healthy	JJ
cord-015021-pol2qm74	1506	25	control	control	NN
cord-015021-pol2qm74	1506	26	(	(	-LRB-
cord-015021-pol2qm74	1506	27	n=10	n=10	NNP
cord-015021-pol2qm74	1506	28	)	)	-RRB-
cord-015021-pol2qm74	1506	29	,	,	,
cord-015021-pol2qm74	1506	30	were	be	VBD
cord-015021-pol2qm74	1506	31	studied	study	VBN
cord-015021-pol2qm74	1506	32	.	.	.
cord-015021-pol2qm74	1507	1	Blood	blood	NN
cord-015021-pol2qm74	1507	2	was	be	VBD
cord-015021-pol2qm74	1507	3	drawn	draw	VBN
cord-015021-pol2qm74	1507	4	in	in	IN
cord-015021-pol2qm74	1507	5	endotoxio	endotoxio	NNP
cord-015021-pol2qm74	1507	6	free	free	JJ
cord-015021-pol2qm74	1507	7	heparinized	heparinized	JJ
cord-015021-pol2qm74	1507	8	robes	robe	NNS
cord-015021-pol2qm74	1507	9	.	.	.
cord-015021-pol2qm74	1508	1	Stimulation	stimulation	NN
cord-015021-pol2qm74	1508	2	was	be	VBD
cord-015021-pol2qm74	1508	3	achieved	achieve	VBN
cord-015021-pol2qm74	1508	4	by	by	IN
cord-015021-pol2qm74	1508	5	addition	addition	NN
cord-015021-pol2qm74	1508	6	nf75	nf75	NNP
cord-015021-pol2qm74	1508	7	pl	pl	NNP
cord-015021-pol2qm74	1508	8	ofLPS	ofLPS	NNP
cord-015021-pol2qm74	1508	9	(	(	-LRB-
cord-015021-pol2qm74	1508	10	10ng	10ng	NNP
cord-015021-pol2qm74	1508	11	/	/	SYM
cord-015021-pol2qm74	1508	12	ml	ml	NN
cord-015021-pol2qm74	1508	13	)	)	-RRB-
cord-015021-pol2qm74	1508	14	to	to	IN
cord-015021-pol2qm74	1508	15	675	675	CD
cord-015021-pol2qm74	1508	16	I	-PRON-	PRP
cord-015021-pol2qm74	1508	17	d	d	NN
cord-015021-pol2qm74	1508	18	of	of	IN
cord-015021-pol2qm74	1508	19	whole	whole	JJ
cord-015021-pol2qm74	1508	20	blood	blood	NN
cord-015021-pol2qm74	1508	21	in	in	IN
cord-015021-pol2qm74	1508	22	presence	presence	NN
cord-015021-pol2qm74	1508	23	of	of	IN
cord-015021-pol2qm74	1508	24	various	various	JJ
cord-015021-pol2qm74	1508	25	concentrations	concentration	NNS
cord-015021-pol2qm74	1508	26	of	of	IN
cord-015021-pol2qm74	1508	27	PTX	PTX	NNP
cord-015021-pol2qm74	1508	28	(	(	-LRB-
cord-015021-pol2qm74	1508	29	0	0	CD
cord-015021-pol2qm74	1508	30	,	,	,
cord-015021-pol2qm74	1508	31	10	10	CD
cord-015021-pol2qm74	1508	32	"	"	``
cord-015021-pol2qm74	1508	33	5	5	CD
cord-015021-pol2qm74	1508	34	,	,	,
cord-015021-pol2qm74	1508	35	10	10	CD
cord-015021-pol2qm74	1508	36	-4	-4	NNS
cord-015021-pol2qm74	1508	37	,	,	,
cord-015021-pol2qm74	1508	38	10	10	CD
cord-015021-pol2qm74	1508	39	"	"	``
cord-015021-pol2qm74	1508	40	3	3	CD
cord-015021-pol2qm74	1508	41	,	,	,
cord-015021-pol2qm74	1508	42	I0"2	I0"2	NNP
cord-015021-pol2qm74	1508	43	M	M	NNP
cord-015021-pol2qm74	1508	44	)	)	-RRB-
cord-015021-pol2qm74	1508	45	.	.	.
cord-015021-pol2qm74	1509	1	After	after	IN
cord-015021-pol2qm74	1509	2	5	5	CD
cord-015021-pol2qm74	1509	3	hrs	hrs	NN
cord-015021-pol2qm74	1509	4	incubation	incubation	NN
cord-015021-pol2qm74	1509	5	at	at	IN
cord-015021-pol2qm74	1509	6	37	37	CD
cord-015021-pol2qm74	1509	7	°	°	NN
cord-015021-pol2qm74	1509	8	C	c	NN
cord-015021-pol2qm74	1509	9	,	,	,
cord-015021-pol2qm74	1509	10	the	the	DT
cord-015021-pol2qm74	1509	11	tubes	tube	NNS
cord-015021-pol2qm74	1509	12	were	be	VBD
cord-015021-pol2qm74	1509	13	centrifuged	centrifuge	VBN
cord-015021-pol2qm74	1509	14	and	and	CC
cord-015021-pol2qm74	1509	15	supematants	supematant	NNS
cord-015021-pol2qm74	1509	16	frozen	freeze	VBN
cord-015021-pol2qm74	1509	17	at	at	IN
cord-015021-pol2qm74	1509	18	-80	-80	NNP
cord-015021-pol2qm74	1509	19	°	°	NN
cord-015021-pol2qm74	1509	20	C	C	NNP
cord-015021-pol2qm74	1509	21	.	.	.
cord-015021-pol2qm74	1510	1	TNFa	TNFa	NNP
cord-015021-pol2qm74	1510	2	and	and	CC
cord-015021-pol2qm74	1510	3	/	/	SYM
cord-015021-pol2qm74	1510	4	L6	L6	NNP
cord-015021-pol2qm74	1510	5	were	be	VBD
cord-015021-pol2qm74	1510	6	measured	measure	VBN
cord-015021-pol2qm74	1510	7	by	by	IN
cord-015021-pol2qm74	1510	8	ELISA	ELISA	NNP
cord-015021-pol2qm74	1510	9	(	(	-LRB-
cord-015021-pol2qm74	1510	10	Medgenix	Medgenix	NNP
cord-015021-pol2qm74	1510	11	R	R	NNP
cord-015021-pol2qm74	1510	12	and	and	CC
cord-015021-pol2qm74	1510	13	Immunotech	Immunotech	NNP
cord-015021-pol2qm74	1510	14	R	R	NNP
cord-015021-pol2qm74	1510	15	respectively	respectively	RB
cord-015021-pol2qm74	1510	16	)	)	-RRB-
cord-015021-pol2qm74	1510	17	.	.	.
cord-015021-pol2qm74	1511	1	Monocytes	monocyte	NNS
cord-015021-pol2qm74	1511	2	were	be	VBD
cord-015021-pol2qm74	1511	3	quantified	quantify	VBN
cord-015021-pol2qm74	1511	4	on	on	IN
cord-015021-pol2qm74	1511	5	a	a	DT
cord-015021-pol2qm74	1511	6	Technicon	Technicon	NNP
cord-015021-pol2qm74	1511	7	H6000	h6000	NN
cord-015021-pol2qm74	1511	8	.	.	.
cord-015021-pol2qm74	1512	1	The	the	DT
cord-015021-pol2qm74	1512	2	results	result	NNS
cord-015021-pol2qm74	1512	3	are	be	VBP
cord-015021-pol2qm74	1512	4	expressed	express	VBN
cord-015021-pol2qm74	1512	5	as	as	IN
cord-015021-pol2qm74	1512	6	median	median	JJ
cord-015021-pol2qm74	1512	7	values	value	NNS
cord-015021-pol2qm74	1512	8	.	.	.
cord-015021-pol2qm74	1513	1	Non	non	JJ
cord-015021-pol2qm74	1513	2	parametric	parametric	JJ
cord-015021-pol2qm74	1513	3	tests	test	NNS
cord-015021-pol2qm74	1513	4	are	be	VBP
cord-015021-pol2qm74	1513	5	used	use	VBN
cord-015021-pol2qm74	1513	6	for	for	IN
cord-015021-pol2qm74	1513	7	testing	test	VBG
cord-015021-pol2qm74	1513	8	differences	difference	NNS
cord-015021-pol2qm74	1513	9	between	between	IN
cord-015021-pol2qm74	1513	10	groups	group	NNS
cord-015021-pol2qm74	1513	11	.	.	.
cord-015021-pol2qm74	1514	1	HI	HI	NNP
cord-015021-pol2qm74	1514	2	RESULTS	result	NNS
cord-015021-pol2qm74	1514	3	,	,	,
cord-015021-pol2qm74	1514	4	TNFtx	TNFtx	NNP
cord-015021-pol2qm74	1514	5	and	and	CC
cord-015021-pol2qm74	1514	6	11,6	11,6	CD
cord-015021-pol2qm74	1514	7	,	,	,
cord-015021-pol2qm74	1514	8	corrected	correct	VBN
cord-015021-pol2qm74	1514	9	for	for	IN
cord-015021-pol2qm74	1514	10	monocytes	monocyte	NNS
cord-015021-pol2qm74	1514	11	count	count	NN
cord-015021-pol2qm74	1514	12	,	,	,
cord-015021-pol2qm74	1514	13	are	be	VBP
cord-015021-pol2qm74	1514	14	given	give	VBN
cord-015021-pol2qm74	1514	15	as	as	IN
cord-015021-pol2qm74	1514	16	%	%	NN
cord-015021-pol2qm74	1514	17	of	of	IN
cord-015021-pol2qm74	1514	18	their	-PRON-	PRP$
cord-015021-pol2qm74	1514	19	initial	initial	JJ
cord-015021-pol2qm74	1514	20	value	value	NN
cord-015021-pol2qm74	1514	21	,	,	,
cord-015021-pol2qm74	1514	22	the	the	DT
cord-015021-pol2qm74	1514	23	baseline	baseline	NN
cord-015021-pol2qm74	1514	24	before	before	IN
cord-015021-pol2qm74	1514	25	stimulation	stimulation	NN
cord-015021-pol2qm74	1514	26	or	or	CC
cord-015021-pol2qm74	1514	27	inhibition	inhibition	NN
cord-015021-pol2qm74	1514	28	being	be	VBG
cord-015021-pol2qm74	1514	29	100	100	CD
cord-015021-pol2qm74	1514	30	%	%	NN
cord-015021-pol2qm74	1514	31	,	,	,
cord-015021-pol2qm74	1514	32	1	1	CD
cord-015021-pol2qm74	1514	33	)	)	-RRB-
cord-015021-pol2qm74	1514	34	STIMULATION	stimulation	NN
cord-015021-pol2qm74	1514	35	BY	by	IN
cord-015021-pol2qm74	1514	36	LPS	lp	NNS
cord-015021-pol2qm74	1514	37	.	.	.
cord-015021-pol2qm74	1515	1	The	the	DT
cord-015021-pol2qm74	1515	2	control	control	NN
cord-015021-pol2qm74	1515	3	group	group	NN
cord-015021-pol2qm74	1515	4	is	be	VBZ
cord-015021-pol2qm74	1515	5	much	much	RB
cord-015021-pol2qm74	1515	6	more	more	RBR
cord-015021-pol2qm74	1515	7	stimulated	stimulated	JJ
cord-015021-pol2qm74	1515	8	(	(	-LRB-
cord-015021-pol2qm74	1515	9	>	>	XX
cord-015021-pol2qm74	1516	1	21000	21000	CD
cord-015021-pol2qm74	1516	2	%	%	NN
cord-015021-pol2qm74	1516	3	for	for	IN
cord-015021-pol2qm74	1516	4	IL6	il6	NN
cord-015021-pol2qm74	1516	5	,	,	,
cord-015021-pol2qm74	1516	6	>	>	XX
cord-015021-pol2qm74	1516	7	8000	8000	CD
cord-015021-pol2qm74	1516	8	%	%	NN
cord-015021-pol2qm74	1516	9	for	for	IN
cord-015021-pol2qm74	1516	10	TNFa	TNFa	NNS
cord-015021-pol2qm74	1516	11	)	)	-RRB-
cord-015021-pol2qm74	1516	12	.	.	.
cord-015021-pol2qm74	1517	1	Blood	blood	NN
cord-015021-pol2qm74	1517	2	samples	sample	NNS
cord-015021-pol2qm74	1517	3	taken	take	VBN
cord-015021-pol2qm74	1517	4	postoperatively	postoperatively	RB
cord-015021-pol2qm74	1517	5	and	and	CC
cord-015021-pol2qm74	1517	6	in	in	IN
cord-015021-pol2qm74	1517	7	patients	patient	NNS
cord-015021-pol2qm74	1517	8	with	with	IN
cord-015021-pol2qm74	1517	9	simple	simple	JJ
cord-015021-pol2qm74	1517	10	sepsis	sepsis	NN
cord-015021-pol2qm74	1517	11	are	be	VBP
cord-015021-pol2qm74	1517	12	significantly	significantly	RB
cord-015021-pol2qm74	1517	13	less	less	RBR
cord-015021-pol2qm74	1517	14	stimulated	stimulate	VBN
cord-015021-pol2qm74	1517	15	(	(	-LRB-
cord-015021-pol2qm74	1517	16	>	>	NFP
cord-015021-pol2qm74	1517	17	1500	1500	CD
cord-015021-pol2qm74	1517	18	%	%	NN
cord-015021-pol2qm74	1517	19	for	for	IN
cord-015021-pol2qm74	1517	20	IL6	il6	NN
cord-015021-pol2qm74	1517	21	,	,	,
cord-015021-pol2qm74	1517	22	>	>	XX
cord-015021-pol2qm74	1517	23	600	600	CD
cord-015021-pol2qm74	1517	24	%	%	NN
cord-015021-pol2qm74	1517	25	for	for	IN
cord-015021-pol2qm74	1517	26	TNFa	TNFa	NNS
cord-015021-pol2qm74	1517	27	)	)	-RRB-
cord-015021-pol2qm74	1517	28	.	.	.
cord-015021-pol2qm74	1518	1	The	the	DT
cord-015021-pol2qm74	1518	2	lowest	low	JJS
cord-015021-pol2qm74	1518	3	stimulation	stimulation	NN
cord-015021-pol2qm74	1518	4	was	be	VBD
cord-015021-pol2qm74	1518	5	observed	observe	VBN
cord-015021-pol2qm74	1518	6	in	in	IN
cord-015021-pol2qm74	1518	7	patients	patient	NNS
cord-015021-pol2qm74	1518	8	with	with	IN
cord-015021-pol2qm74	1518	9	septic	septic	JJ
cord-015021-pol2qm74	1518	10	shock	shock	NN
cord-015021-pol2qm74	1518	11	(	(	-LRB-
cord-015021-pol2qm74	1518	12	median	median	NN
cord-015021-pol2qm74	1518	13	=	=	SYM
cord-015021-pol2qm74	1518	14	168	168	CD
cord-015021-pol2qm74	1518	15	%	%	NN
cord-015021-pol2qm74	1518	16	)	)	-RRB-
cord-015021-pol2qm74	1518	17	,	,	,
cord-015021-pol2qm74	1518	18	some	some	DT
cord-015021-pol2qm74	1518	19	patients	patient	NNS
cord-015021-pol2qm74	1518	20	being	be	VBG
cord-015021-pol2qm74	1518	21	not	not	RB
cord-015021-pol2qm74	1518	22	stimulated	stimulate	VBN
cord-015021-pol2qm74	1518	23	at	at	RB
cord-015021-pol2qm74	1518	24	all	all	RB
cord-015021-pol2qm74	1518	25	.	.	.
cord-015021-pol2qm74	1519	1	2)EFFECTS	2)effects	CD
cord-015021-pol2qm74	1520	1	OF	of	IN
cord-015021-pol2qm74	1520	2	PTX.The	PTX.The	NNP
cord-015021-pol2qm74	1520	3	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1520	4	effect	effect	NN
cord-015021-pol2qm74	1520	5	of	of	IN
cord-015021-pol2qm74	1520	6	PTX	PTX	NNP
cord-015021-pol2qm74	1520	7	on	on	IN
cord-015021-pol2qm74	1520	8	TNFtx	tnftx	DT
cord-015021-pol2qm74	1520	9	production	production	NN
cord-015021-pol2qm74	1520	10	is	be	VBZ
cord-015021-pol2qm74	1520	11	effective	effective	JJ
cord-015021-pol2qm74	1520	12	in	in	IN
cord-015021-pol2qm74	1520	13	all	all	DT
cord-015021-pol2qm74	1520	14	groups	group	NNS
cord-015021-pol2qm74	1520	15	at	at	IN
cord-015021-pol2qm74	1520	16	10	10	CD
cord-015021-pol2qm74	1520	17	-3	-3	NNP
cord-015021-pol2qm74	1520	18	M	M	NNP
cord-015021-pol2qm74	1520	19	(	(	-LRB-
cord-015021-pol2qm74	1520	20	reduction	reduction	NN
cord-015021-pol2qm74	1520	21	to	to	IN
cord-015021-pol2qm74	1520	22	less	less	JJR
cord-015021-pol2qm74	1520	23	than	than	IN
cord-015021-pol2qm74	1520	24	'	'	''
cord-015021-pol2qm74	1520	25	¼	¼	CD
cord-015021-pol2qm74	1520	26	of	of	IN
cord-015021-pol2qm74	1520	27	the	the	DT
cord-015021-pol2qm74	1520	28	median	median	JJ
cord-015021-pol2qm74	1520	29	values	value	NNS
cord-015021-pol2qm74	1520	30	)	)	-RRB-
cord-015021-pol2qm74	1520	31	,	,	,
cord-015021-pol2qm74	1520	32	and	and	CC
cord-015021-pol2qm74	1520	33	is	be	VBZ
cord-015021-pol2qm74	1520	34	almost	almost	RB
cord-015021-pol2qm74	1520	35	complete	complete	JJ
cord-015021-pol2qm74	1520	36	at	at	IN
cord-015021-pol2qm74	1520	37	10	10	CD
cord-015021-pol2qm74	1520	38	"	"	``
cord-015021-pol2qm74	1520	39	2	2	CD
cord-015021-pol2qm74	1520	40	M.	m.	NN
cord-015021-pol2qm74	1521	1	The	the	DT
cord-015021-pol2qm74	1521	2	septic	septic	JJ
cord-015021-pol2qm74	1521	3	shock	shock	NN
cord-015021-pol2qm74	1521	4	group	group	NN
cord-015021-pol2qm74	1521	5	has	have	VBZ
cord-015021-pol2qm74	1521	6	a	a	DT
cord-015021-pol2qm74	1521	7	decreased	decrease	VBN
cord-015021-pol2qm74	1521	8	sensitivity	sensitivity	NN
cord-015021-pol2qm74	1521	9	to	to	IN
cord-015021-pol2qm74	1521	10	PTX	PTX	NNP
cord-015021-pol2qm74	1521	11	.	.	.
cord-015021-pol2qm74	1522	1	IL6	il6	NN
cord-015021-pol2qm74	1522	2	production	production	NN
cord-015021-pol2qm74	1522	3	exhibits	exhibit	VBZ
cord-015021-pol2qm74	1522	4	a	a	DT
cord-015021-pol2qm74	1522	5	lesser	less	JJR
cord-015021-pol2qm74	1522	6	reduction	reduction	NN
cord-015021-pol2qm74	1522	7	at	at	IN
cord-015021-pol2qm74	1522	8	10	10	CD
cord-015021-pol2qm74	1522	9	-3	-3	NNP
cord-015021-pol2qm74	1522	10	M	M	NNP
cord-015021-pol2qm74	1522	11	(	(	-LRB-
cord-015021-pol2qm74	1522	12	~	~	NFP
cord-015021-pol2qm74	1522	13	'	'	''
cord-015021-pol2qm74	1522	14	A	a	DT
cord-015021-pol2qm74	1522	15	to	to	IN
cord-015021-pol2qm74	1522	16	½	½	NN
cord-015021-pol2qm74	1522	17	of	of	IN
cord-015021-pol2qm74	1522	18	the	the	DT
cord-015021-pol2qm74	1522	19	median	median	JJ
cord-015021-pol2qm74	1522	20	values	value	NNS
cord-015021-pol2qm74	1522	21	)	)	-RRB-
cord-015021-pol2qm74	1522	22	,	,	,
cord-015021-pol2qm74	1522	23	further	further	RB
cord-015021-pol2qm74	1522	24	increased	increase	VBD
cord-015021-pol2qm74	1522	25	at	at	IN
cord-015021-pol2qm74	1522	26	10	10	CD
cord-015021-pol2qm74	1522	27	-2	-2	NN
cord-015021-pol2qm74	1522	28	M.	m.	NN
cord-015021-pol2qm74	1523	1	The	the	DT
cord-015021-pol2qm74	1523	2	septic	septic	JJ
cord-015021-pol2qm74	1523	3	shock	shock	NN
cord-015021-pol2qm74	1523	4	group	group	NN
cord-015021-pol2qm74	1523	5	is	be	VBZ
cord-015021-pol2qm74	1523	6	again	again	RB
cord-015021-pol2qm74	1523	7	less	less	RBR
cord-015021-pol2qm74	1523	8	sensitive	sensitive	JJ
cord-015021-pol2qm74	1523	9	to	to	IN
cord-015021-pol2qm74	1523	10	PTX	PTX	NNP
cord-015021-pol2qm74	1523	11	.	.	.
cord-015021-pol2qm74	1524	1	IV	IV	NNP
cord-015021-pol2qm74	1524	2	CONCLUSION	CONCLUSION	NNP
cord-015021-pol2qm74	1524	3	:	:	:
cord-015021-pol2qm74	1525	1	The	the	DT
cord-015021-pol2qm74	1525	2	reduced	reduce	VBN
cord-015021-pol2qm74	1525	3	ability	ability	NN
cord-015021-pol2qm74	1525	4	of	of	IN
cord-015021-pol2qm74	1525	5	circulating	circulate	VBG
cord-015021-pol2qm74	1525	6	monocytes	monocyte	NNS
cord-015021-pol2qm74	1525	7	to	to	TO
cord-015021-pol2qm74	1525	8	produce	produce	VB
cord-015021-pol2qm74	1525	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	1525	10	during	during	IN
cord-015021-pol2qm74	1525	11	severe	severe	JJ
cord-015021-pol2qm74	1525	12	infections	infection	NNS
cord-015021-pol2qm74	1525	13	is	be	VBZ
cord-015021-pol2qm74	1525	14	confirmed	confirm	VBN
cord-015021-pol2qm74	1525	15	here	here	RB
cord-015021-pol2qm74	1525	16	.	.	.
cord-015021-pol2qm74	1526	1	PTX	PTX	NNP
cord-015021-pol2qm74	1526	2	is	be	VBZ
cord-015021-pol2qm74	1526	3	able	able	JJ
cord-015021-pol2qm74	1526	4	to	to	TO
cord-015021-pol2qm74	1526	5	reduce	reduce	VB
cord-015021-pol2qm74	1526	6	significantly	significantly	RB
cord-015021-pol2qm74	1526	7	TNFc~	tnfc~	CD
cord-015021-pol2qm74	1526	8	at	at	IN
cord-015021-pol2qm74	1526	9	10	10	CD
cord-015021-pol2qm74	1526	10	-3	-3	NNP
cord-015021-pol2qm74	1526	11	M	M	NNP
cord-015021-pol2qm74	1526	12	and	and	CC
cord-015021-pol2qm74	1526	13	the	the	DT
cord-015021-pol2qm74	1526	14	inhibition	inhibition	NN
cord-015021-pol2qm74	1526	15	is	be	VBZ
cord-015021-pol2qm74	1526	16	nearly	nearly	RB
cord-015021-pol2qm74	1526	17	complete	complete	JJ
cord-015021-pol2qm74	1526	18	at	at	IN
cord-015021-pol2qm74	1526	19	10	10	CD
cord-015021-pol2qm74	1526	20	-2	-2	NN
cord-015021-pol2qm74	1526	21	M.	m.	NN
cord-015021-pol2qm74	1527	1	Surprisingly	surprisingly	RB
cord-015021-pol2qm74	1527	2	,	,	,
cord-015021-pol2qm74	1527	3	there	there	EX
cord-015021-pol2qm74	1527	4	is	be	VBZ
cord-015021-pol2qm74	1527	5	a	a	DT
cord-015021-pol2qm74	1527	6	lesser	less	JJR
cord-015021-pol2qm74	1527	7	,	,	,
cord-015021-pol2qm74	1527	8	but	but	CC
cord-015021-pol2qm74	1527	9	significant	significant	JJ
cord-015021-pol2qm74	1527	10	suppressive	suppressive	JJ
cord-015021-pol2qm74	1527	11	action	action	NN
cord-015021-pol2qm74	1527	12	of	of	IN
cord-015021-pol2qm74	1527	13	PTX	PTX	NNP
cord-015021-pol2qm74	1527	14	on	on	IN
cord-015021-pol2qm74	1527	15	IL6	IL6	NNP
cord-015021-pol2qm74	1527	16	,	,	,
cord-015021-pol2qm74	1527	17	not	not	RB
cord-015021-pol2qm74	1527	18	found	find	VBN
cord-015021-pol2qm74	1527	19	in	in	IN
cord-015021-pol2qm74	1527	20	experiments	experiment	NNS
cord-015021-pol2qm74	1527	21	using	use	VBG
cord-015021-pol2qm74	1527	22	purified	purify	VBN
cord-015021-pol2qm74	1527	23	monocytes	monocyte	NNS
cord-015021-pol2qm74	1527	24	.	.	.
cord-015021-pol2qm74	1528	1	One	one	CD
cord-015021-pol2qm74	1528	2	possible	possible	JJ
cord-015021-pol2qm74	1528	3	explination	explination	NN
cord-015021-pol2qm74	1528	4	could	could	MD
cord-015021-pol2qm74	1528	5	be	be	VB
cord-015021-pol2qm74	1528	6	the	the	DT
cord-015021-pol2qm74	1528	7	interplay	interplay	NN
cord-015021-pol2qm74	1528	8	between	between	IN
cord-015021-pol2qm74	1528	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	1528	10	production	production	NN
cord-015021-pol2qm74	1528	11	.	.	.
cord-015021-pol2qm74	1529	1	(	(	-LRB-
cord-015021-pol2qm74	1529	2	1	1	CD
cord-015021-pol2qm74	1529	3	)	)	-RRB-
cord-015021-pol2qm74	1530	1	Lymphokine	lymphokine	NN
cord-015021-pol2qm74	1530	2	research	research	NN
cord-015021-pol2qm74	1530	3	(	(	-LRB-
cord-015021-pol2qm74	1531	1	1989	1989	LS
cord-015021-pol2qm74	1531	2	)	)	-RRB-
cord-015021-pol2qm74	1531	3	cDNA	cdna	NN
cord-015021-pol2qm74	1531	4	sequencing	sequencing	NN
cord-015021-pol2qm74	1531	5	constitutes	constitute	VBZ
cord-015021-pol2qm74	1531	6	a	a	DT
cord-015021-pol2qm74	1531	7	powerful	powerful	JJ
cord-015021-pol2qm74	1531	8	method	method	NN
cord-015021-pol2qm74	1531	9	of	of	IN
cord-015021-pol2qm74	1531	10	measuring	measure	VBG
cord-015021-pol2qm74	1531	11	steady	steady	JJ
cord-015021-pol2qm74	1531	12	-	-	HYPH
cord-015021-pol2qm74	1531	13	state	state	NN
cord-015021-pol2qm74	1531	14	mRNA	mrna	NN
cord-015021-pol2qm74	1531	15	levels	level	NNS
cord-015021-pol2qm74	1531	16	for	for	IN
cord-015021-pol2qm74	1531	17	all	all	DT
cord-015021-pol2qm74	1531	18	genes	gene	NNS
cord-015021-pol2qm74	1531	19	transcribed	transcribe	VBN
cord-015021-pol2qm74	1531	20	in	in	IN
cord-015021-pol2qm74	1531	21	a	a	DT
cord-015021-pol2qm74	1531	22	given	give	VBN
cord-015021-pol2qm74	1531	23	cell	cell	NN
cord-015021-pol2qm74	1531	24	or	or	CC
cord-015021-pol2qm74	1531	25	tissue	tissue	NN
cord-015021-pol2qm74	1531	26	at	at	IN
cord-015021-pol2qm74	1531	27	a	a	DT
cord-015021-pol2qm74	1531	28	particular	particular	JJ
cord-015021-pol2qm74	1531	29	stage	stage	NN
cord-015021-pol2qm74	1531	30	of	of	IN
cord-015021-pol2qm74	1531	31	differentiation	differentiation	NN
cord-015021-pol2qm74	1531	32	.	.	.
cord-015021-pol2qm74	1532	1	By	by	IN
cord-015021-pol2qm74	1532	2	comparing	compare	VBG
cord-015021-pol2qm74	1532	3	transcript	transcript	NN
cord-015021-pol2qm74	1532	4	abundance	abundance	NN
cord-015021-pol2qm74	1532	5	both	both	DT
cord-015021-pol2qm74	1532	6	prior	prior	RB
cord-015021-pol2qm74	1532	7	to	to	IN
cord-015021-pol2qm74	1532	8	and	and	CC
cord-015021-pol2qm74	1532	9	following	follow	VBG
cord-015021-pol2qm74	1532	10	differentiation	differentiation	NN
cord-015021-pol2qm74	1532	11	,	,	,
cord-015021-pol2qm74	1532	12	individual	individual	JJ
cord-015021-pol2qm74	1532	13	genes	gene	NNS
cord-015021-pol2qm74	1532	14	can	can	MD
cord-015021-pol2qm74	1532	15	be	be	VB
cord-015021-pol2qm74	1532	16	identified	identify	VBN
cord-015021-pol2qm74	1532	17	whose	whose	WP$
cord-015021-pol2qm74	1532	18	transcription	transcription	NN
cord-015021-pol2qm74	1532	19	is	be	VBZ
cord-015021-pol2qm74	1532	20	regulated	regulate	VBN
cord-015021-pol2qm74	1532	21	both	both	CC
cord-015021-pol2qm74	1532	22	positively	positively	RB
cord-015021-pol2qm74	1532	23	and	and	CC
cord-015021-pol2qm74	1532	24	negatively	negatively	RB
cord-015021-pol2qm74	1532	25	.	.	.
cord-015021-pol2qm74	1533	1	In	in	IN
cord-015021-pol2qm74	1533	2	order	order	NN
cord-015021-pol2qm74	1533	3	to	to	TO
cord-015021-pol2qm74	1533	4	examine	examine	VB
cord-015021-pol2qm74	1533	5	monocyte	monocyte	NNP
cord-015021-pol2qm74	1533	6	activation	activation	NN
cord-015021-pol2qm74	1533	7	,	,	,
cord-015021-pol2qm74	1533	8	the	the	DT
cord-015021-pol2qm74	1533	9	human	human	JJ
cord-015021-pol2qm74	1533	10	monocyte	monocyte	NNP
cord-015021-pol2qm74	1533	11	line	line	NN
cord-015021-pol2qm74	1533	12	THP-1	THP-1	NNP
cord-015021-pol2qm74	1533	13	was	be	VBD
cord-015021-pol2qm74	1533	14	induced	induce	VBN
cord-015021-pol2qm74	1533	15	with	with	IN
cord-015021-pol2qm74	1533	16	phorbol	phorbol	NNP
cord-015021-pol2qm74	1533	17	ester	ester	NNP
cord-015021-pol2qm74	1533	18	(	(	-LRB-
cord-015021-pol2qm74	1533	19	48	48	CD
cord-015021-pol2qm74	1533	20	h	h	NN
cord-015021-pol2qm74	1533	21	)	)	-RRB-
cord-015021-pol2qm74	1533	22	and	and	CC
cord-015021-pol2qm74	1533	23	activated	activate	VBD
cord-015021-pol2qm74	1533	24	for	for	IN
cord-015021-pol2qm74	1533	25	4	4	CD
cord-015021-pol2qm74	1533	26	h	h	NN
cord-015021-pol2qm74	1533	27	with	with	IN
cord-015021-pol2qm74	1533	28	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	1533	29	(	(	-LRB-
cord-015021-pol2qm74	1533	30	LPS	LPS	NNP
cord-015021-pol2qm74	1533	31	)	)	-RRB-
cord-015021-pol2qm74	1533	32	after	after	IN
cord-015021-pol2qm74	1533	33	which	which	WDT
cord-015021-pol2qm74	1533	34	polyA	polyA	NNP
cord-015021-pol2qm74	1533	35	+	+	CC
cord-015021-pol2qm74	1534	1	RNA	RNA	NNP
cord-015021-pol2qm74	1534	2	was	be	VBD
cord-015021-pol2qm74	1534	3	purified	purify	VBN
cord-015021-pol2qm74	1534	4	.	.	.
cord-015021-pol2qm74	1535	1	The	the	DT
cord-015021-pol2qm74	1535	2	RNA	RNA	NNP
cord-015021-pol2qm74	1535	3	from	from	IN
cord-015021-pol2qm74	1535	4	control	control	NN
cord-015021-pol2qm74	1535	5	and	and	CC
cord-015021-pol2qm74	1535	6	LPS	LPS	NNP
cord-015021-pol2qm74	1535	7	-	-	HYPH
cord-015021-pol2qm74	1535	8	treated	treat	VBN
cord-015021-pol2qm74	1535	9	cells	cell	NNS
cord-015021-pol2qm74	1535	10	were	be	VBD
cord-015021-pol2qm74	1535	11	each	each	DT
cord-015021-pol2qm74	1535	12	used	use	VBN
cord-015021-pol2qm74	1535	13	to	to	TO
cord-015021-pol2qm74	1535	14	construct	construct	VB
cord-015021-pol2qm74	1535	15	a	a	DT
cord-015021-pol2qm74	1535	16	cDNA	cdna	NN
cord-015021-pol2qm74	1535	17	library	library	NN
cord-015021-pol2qm74	1535	18	under	under	IN
cord-015021-pol2qm74	1535	19	identical	identical	JJ
cord-015021-pol2qm74	1535	20	conditions	condition	NNS
cord-015021-pol2qm74	1535	21	,	,	,
cord-015021-pol2qm74	1535	22	and	and	CC
cord-015021-pol2qm74	1535	23	all	all	DT
cord-015021-pol2qm74	1535	24	resulting	result	VBG
cord-015021-pol2qm74	1535	25	clones	clone	NNS
cord-015021-pol2qm74	1535	26	were	be	VBD
cord-015021-pol2qm74	1535	27	selected	select	VBN
cord-015021-pol2qm74	1535	28	for	for	IN
cord-015021-pol2qm74	1535	29	cDNA	cdna	NN
cord-015021-pol2qm74	1535	30	sequence	sequence	NN
cord-015021-pol2qm74	1535	31	analysis	analysis	NN
cord-015021-pol2qm74	1535	32	.	.	.
cord-015021-pol2qm74	1536	1	Each	each	DT
cord-015021-pol2qm74	1536	2	clone	clone	NN
cord-015021-pol2qm74	1536	3	sequence	sequence	NN
cord-015021-pol2qm74	1536	4	was	be	VBD
cord-015021-pol2qm74	1536	5	evaluated	evaluate	VBN
cord-015021-pol2qm74	1536	6	by	by	IN
cord-015021-pol2qm74	1536	7	matching	match	VBG
cord-015021-pol2qm74	1536	8	with	with	IN
cord-015021-pol2qm74	1536	9	both	both	DT
cord-015021-pol2qm74	1536	10	GenBank	GenBank	NNP
cord-015021-pol2qm74	1536	11	and	and	CC
cord-015021-pol2qm74	1536	12	our	-PRON-	PRP$
cord-015021-pol2qm74	1536	13	own	own	JJ
cord-015021-pol2qm74	1536	14	gene	gene	NN
cord-015021-pol2qm74	1536	15	databases	database	NNS
cord-015021-pol2qm74	1536	16	.	.	.
cord-015021-pol2qm74	1537	1	Very	very	RB
cord-015021-pol2qm74	1537	2	different	different	JJ
cord-015021-pol2qm74	1537	3	patterns	pattern	NNS
cord-015021-pol2qm74	1537	4	of	of	IN
cord-015021-pol2qm74	1537	5	gene	gene	NN
cord-015021-pol2qm74	1537	6	expression	expression	NN
cord-015021-pol2qm74	1537	7	were	be	VBD
cord-015021-pol2qm74	1537	8	seen	see	VBN
cord-015021-pol2qm74	1537	9	in	in	IN
cord-015021-pol2qm74	1537	10	the	the	DT
cord-015021-pol2qm74	1537	11	two	two	CD
cord-015021-pol2qm74	1537	12	libraries	library	NNS
cord-015021-pol2qm74	1537	13	,	,	,
cord-015021-pol2qm74	1537	14	the	the	DT
cord-015021-pol2qm74	1537	15	latter	latter	JJ
cord-015021-pol2qm74	1537	16	reflecting	reflect	VBG
cord-015021-pol2qm74	1537	17	very	very	RB
cord-015021-pol2qm74	1537	18	high	high	JJ
cord-015021-pol2qm74	1537	19	levels	level	NNS
cord-015021-pol2qm74	1537	20	of	of	IN
cord-015021-pol2qm74	1537	21	known	know	VBN
cord-015021-pol2qm74	1537	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1537	23	mediators	mediator	NNS
cord-015021-pol2qm74	1537	24	such	such	JJ
cord-015021-pol2qm74	1537	25	as	as	IN
cord-015021-pol2qm74	1537	26	IL-1	IL-1	NNP
cord-015021-pol2qm74	1537	27	and	and	CC
cord-015021-pol2qm74	1537	28	TNF	TNF	NNP
cord-015021-pol2qm74	1537	29	.	.	.
cord-015021-pol2qm74	1538	1	A	a	DT
cord-015021-pol2qm74	1538	2	second	second	JJ
cord-015021-pol2qm74	1538	3	set	set	NN
cord-015021-pol2qm74	1538	4	of	of	IN
cord-015021-pol2qm74	1538	5	libraries	library	NNS
cord-015021-pol2qm74	1538	6	were	be	VBD
cord-015021-pol2qm74	1538	7	made	make	VBN
cord-015021-pol2qm74	1538	8	from	from	IN
cord-015021-pol2qm74	1538	9	umbilical	umbilical	JJ
cord-015021-pol2qm74	1538	10	vein	vein	NN
cord-015021-pol2qm74	1538	11	endothelial	endothelial	JJ
cord-015021-pol2qm74	1538	12	cells	cell	NNS
cord-015021-pol2qm74	1538	13	(	(	-LRB-
cord-015021-pol2qm74	1538	14	HUVEC	HUVEC	NNP
cord-015021-pol2qm74	1538	15	)	)	-RRB-
cord-015021-pol2qm74	1538	16	,	,	,
cord-015021-pol2qm74	1538	17	both	both	CC
cord-015021-pol2qm74	1538	18	with	with	IN
cord-015021-pol2qm74	1538	19	and	and	CC
cord-015021-pol2qm74	1538	20	without	without	IN
cord-015021-pol2qm74	1538	21	LPS	LPS	NNP
cord-015021-pol2qm74	1538	22	stimulation	stimulation	NN
cord-015021-pol2qm74	1538	23	,	,	,
cord-015021-pol2qm74	1538	24	and	and	CC
cord-015021-pol2qm74	1538	25	were	be	VBD
cord-015021-pol2qm74	1538	26	analyzed	analyze	VBN
cord-015021-pol2qm74	1538	27	in	in	IN
cord-015021-pol2qm74	1538	28	a	a	DT
cord-015021-pol2qm74	1538	29	similar	similar	JJ
cord-015021-pol2qm74	1538	30	fashion	fashion	NN
cord-015021-pol2qm74	1538	31	.	.	.
cord-015021-pol2qm74	1539	1	The	the	DT
cord-015021-pol2qm74	1539	2	effects	effect	NNS
cord-015021-pol2qm74	1539	3	of	of	IN
cord-015021-pol2qm74	1539	4	LPS	LPS	NNP
cord-015021-pol2qm74	1539	5	induction	induction	NN
cord-015021-pol2qm74	1539	6	on	on	IN
cord-015021-pol2qm74	1539	7	specific	specific	JJ
cord-015021-pol2qm74	1539	8	gene	gene	NN
cord-015021-pol2qm74	1539	9	transcription	transcription	NN
cord-015021-pol2qm74	1539	10	in	in	IN
cord-015021-pol2qm74	1539	11	both	both	DT
cord-015021-pol2qm74	1539	12	cell	cell	NN
cord-015021-pol2qm74	1539	13	types	type	NNS
cord-015021-pol2qm74	1539	14	will	will	MD
cord-015021-pol2qm74	1539	15	be	be	VB
cord-015021-pol2qm74	1539	16	discussed	discuss	VBN
cord-015021-pol2qm74	1539	17	.	.	.
cord-015021-pol2qm74	1540	1	T.	T.	NNP
cord-015021-pol2qm74	1540	2	Tadros	Tadros	NNP
cord-015021-pol2qm74	1540	3	,	,	,
cord-015021-pol2qm74	1540	4	MD	MD	NNP
cord-015021-pol2qm74	1540	5	,	,	,
cord-015021-pol2qm74	1540	6	Th	Th	NNP
cord-015021-pol2qm74	1540	7	Wobbes	Wobbes	NNP
cord-015021-pol2qm74	1540	8	,	,	,
cord-015021-pol2qm74	1540	9	ME	ME	NNP
cord-015021-pol2qm74	1540	10	)	)	-RRB-
cord-015021-pol2qm74	1540	11	PhD	phd	NN
cord-015021-pol2qm74	1540	12	,	,	,
cord-015021-pol2qm74	1540	13	RJA	RJA	NNP
cord-015021-pol2qm74	1540	14	Goris	Goris	NNP
cord-015021-pol2qm74	1540	15	,	,	,
cord-015021-pol2qm74	1540	16	MD	MD	NNP
cord-015021-pol2qm74	1540	17	PhD	phd	NN
cord-015021-pol2qm74	1541	1	To	to	TO
cord-015021-pol2qm74	1541	2	investigate	investigate	VB
cord-015021-pol2qm74	1541	3	whether	whether	IN
cord-015021-pol2qm74	1541	4	the	the	DT
cord-015021-pol2qm74	1541	5	preactivation	preactivation	NN
cord-015021-pol2qm74	1541	6	of	of	IN
cord-015021-pol2qm74	1541	7	regional	regional	JJ
cord-015021-pol2qm74	1541	8	macrophuges	macrophuge	NNS
cord-015021-pol2qm74	1541	9	by	by	IN
cord-015021-pol2qm74	1541	10	liposomes	liposome	NNS
cord-015021-pol2qm74	1541	11	containing	contain	VBG
cord-015021-pol2qm74	1541	12	muramyl	muramyl	NNP
cord-015021-pol2qm74	1541	13	tripeptide	tripeptide	NNP
cord-015021-pol2qm74	1541	14	(	(	-LRB-
cord-015021-pol2qm74	1541	15	MTP	MTP	NNP
cord-015021-pol2qm74	1541	16	-	-	HYPH
cord-015021-pol2qm74	1541	17	PE	PE	NNP
cord-015021-pol2qm74	1541	18	)	)	-RRB-
cord-015021-pol2qm74	1541	19	can	can	MD
cord-015021-pol2qm74	1541	20	counteract	counteract	VB
cord-015021-pol2qm74	1541	21	the	the	DT
cord-015021-pol2qm74	1541	22	detrimental	detrimental	JJ
cord-015021-pol2qm74	1541	23	effect	effect	NN
cord-015021-pol2qm74	1541	24	of	of	IN
cord-015021-pol2qm74	1541	25	blood	blood	NN
cord-015021-pol2qm74	1541	26	transfusions	transfusion	NNS
cord-015021-pol2qm74	1541	27	on	on	IN
cord-015021-pol2qm74	1541	28	both	both	DT
cord-015021-pol2qm74	1541	29	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	1541	30	repair	repair	NN
cord-015021-pol2qm74	1541	31	and	and	CC
cord-015021-pol2qm74	1541	32	host	host	NN
cord-015021-pol2qm74	1541	33	susceptibility	susceptibility	NN
cord-015021-pol2qm74	1541	34	to	to	IN
cord-015021-pol2qm74	1541	35	infections	infection	NNS
cord-015021-pol2qm74	1541	36	.	.	.
cord-015021-pol2qm74	1542	1	Methods	Methods	NNPS
cord-015021-pol2qm74	1542	2	Eighty	eighty	CD
cord-015021-pol2qm74	1542	3	Lewis	Lewis	NNP
cord-015021-pol2qm74	1542	4	rats	rat	NNS
cord-015021-pol2qm74	1542	5	received	receive	VBD
cord-015021-pol2qm74	1542	6	lmg	lmg	NNP
cord-015021-pol2qm74	1542	7	/	/	SYM
cord-015021-pol2qm74	1542	8	kg	kg	NNS
cord-015021-pol2qm74	1542	9	of	of	IN
cord-015021-pol2qm74	1542	10	either	either	DT
cord-015021-pol2qm74	1542	11	empty	empty	JJ
cord-015021-pol2qm74	1542	12	or	or	CC
cord-015021-pol2qm74	1542	13	MTP	MTP	NNP
cord-015021-pol2qm74	1542	14	-	-	HYPH
cord-015021-pol2qm74	1542	15	PE	PE	NNP
cord-015021-pol2qm74	1542	16	encapsulated	encapsulate	VBN
cord-015021-pol2qm74	1542	17	Liposomes	Liposomes	NNP
cord-015021-pol2qm74	1542	18	,	,	,
cord-015021-pol2qm74	1542	19	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	1542	20	(	(	-LRB-
cord-015021-pol2qm74	1542	21	ip	ip	NN
cord-015021-pol2qm74	1542	22	)	)	-RRB-
cord-015021-pol2qm74	1542	23	.	.	.
cord-015021-pol2qm74	1543	1	Twenty	twenty	CD
cord-015021-pol2qm74	1543	2	-	-	HYPH
cord-015021-pol2qm74	1543	3	four	four	CD
cord-015021-pol2qm74	1543	4	hours	hour	NNS
cord-015021-pol2qm74	1543	5	thereafter	thereafter	RB
cord-015021-pol2qm74	1543	6	,	,	,
cord-015021-pol2qm74	1543	7	the	the	DT
cord-015021-pol2qm74	1543	8	animals	animal	NNS
cord-015021-pol2qm74	1543	9	underwent	undergo	VBD
cord-015021-pol2qm74	1543	10	resection	resection	NN
cord-015021-pol2qm74	1543	11	and	and	CC
cord-015021-pol2qm74	1543	12	anastomosis	anastomosis	NN
cord-015021-pol2qm74	1543	13	of	of	IN
cord-015021-pol2qm74	1543	14	both	both	DT
cord-015021-pol2qm74	1543	15	ileum	ileum	NN
cord-015021-pol2qm74	1543	16	and	and	CC
cord-015021-pol2qm74	1543	17	colon	colon	NN
cord-015021-pol2qm74	1543	18	,	,	,
cord-015021-pol2qm74	1543	19	and	and	CC
cord-015021-pol2qm74	1543	20	received	receive	VBD
cord-015021-pol2qm74	1543	21	3	3	CD
cord-015021-pol2qm74	1543	22	mL	ml	NN
cord-015021-pol2qm74	1543	23	of	of	IN
cord-015021-pol2qm74	1543	24	either	either	DT
cord-015021-pol2qm74	1543	25	saline	saline	NN
cord-015021-pol2qm74	1543	26	or	or	CC
cord-015021-pol2qm74	1543	27	blood	blood	NN
cord-015021-pol2qm74	1543	28	from	from	IN
cord-015021-pol2qm74	1543	29	brown	brown	JJ
cord-015021-pol2qm74	1543	30	Norway	Norway	NNP
cord-015021-pol2qm74	1543	31	donors	donor	NNS
cord-015021-pol2qm74	1543	32	,	,	,
cord-015021-pol2qm74	1544	1	iv	iv	LS
cord-015021-pol2qm74	1544	2	.	.	.
cord-015021-pol2qm74	1545	1	The	the	DT
cord-015021-pol2qm74	1545	2	animals	animal	NNS
cord-015021-pol2qm74	1545	3	were	be	VBD
cord-015021-pol2qm74	1545	4	killed	kill	VBN
cord-015021-pol2qm74	1545	5	3	3	CD
cord-015021-pol2qm74	1545	6	or	or	CC
cord-015021-pol2qm74	1545	7	7	7	CD
cord-015021-pol2qm74	1545	8	days	day	NNS
cord-015021-pol2qm74	1545	9	after	after	IN
cord-015021-pol2qm74	1545	10	surgery	surgery	NN
cord-015021-pol2qm74	1545	11	and	and	CC
cord-015021-pol2qm74	1545	12	examined	examine	VBD
cord-015021-pol2qm74	1545	13	for	for	IN
cord-015021-pol2qm74	1545	14	septic	septic	JJ
cord-015021-pol2qm74	1545	15	complications	complication	NNS
cord-015021-pol2qm74	1545	16	and	and	CC
cord-015021-pol2qm74	1545	17	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	1545	18	repair	repair	NN
cord-015021-pol2qm74	1545	19	.	.	.
cord-015021-pol2qm74	1546	1	The	the	DT
cord-015021-pol2qm74	1546	2	average	average	JJ
cord-015021-pol2qm74	1546	3	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	1546	4	strength	strength	NN
cord-015021-pol2qm74	1546	5	,	,	,
cord-015021-pol2qm74	1546	6	as	as	IN
cord-015021-pol2qm74	1546	7	assessed	assess	VBN
cord-015021-pol2qm74	1546	8	by	by	IN
cord-015021-pol2qm74	1546	9	bursting	burst	VBG
cord-015021-pol2qm74	1546	10	pressure	pressure	NN
cord-015021-pol2qm74	1546	11	(	(	-LRB-
cord-015021-pol2qm74	1546	12	+	+	CD
cord-015021-pol2qm74	1546	13	SD	sd	NN
cord-015021-pol2qm74	1546	14	)	)	-RRB-
cord-015021-pol2qm74	1546	15	,	,	,
cord-015021-pol2qm74	1546	16	was	be	VBD
cord-015021-pol2qm74	1546	17	significantly	significantly	RB
cord-015021-pol2qm74	1546	18	diminished	diminish	VBN
cord-015021-pol2qm74	1546	19	in	in	IN
cord-015021-pol2qm74	1546	20	the	the	DT
cord-015021-pol2qm74	1546	21	transfused	transfuse	VBN
cord-015021-pol2qm74	1546	22	animals	animal	NNS
cord-015021-pol2qm74	1546	23	,	,	,
cord-015021-pol2qm74	1546	24	as	as	IN
cord-015021-pol2qm74	1546	25	compared	compare	VBN
cord-015021-pol2qm74	1546	26	to	to	IN
cord-015021-pol2qm74	1546	27	the	the	DT
cord-015021-pol2qm74	1546	28	non	non	JJ
cord-015021-pol2qm74	1546	29	-	-	JJ
cord-015021-pol2qm74	1546	30	transfused	transfused	JJ
cord-015021-pol2qm74	1546	31	animals	animal	NNS
cord-015021-pol2qm74	1546	32	(	(	-LRB-
cord-015021-pol2qm74	1546	33	ileum;day	ileum;day	NN
cord-015021-pol2qm74	1546	34	3	3	CD
cord-015021-pol2qm74	1546	35	;	;	:
cord-015021-pol2qm74	1546	36	44-+8	44-+8	CD
cord-015021-pol2qm74	1546	37	vs	vs	IN
cord-015021-pol2qm74	1546	38	99	99	CD
cord-015021-pol2qm74	1546	39	+	+	SYM
cord-015021-pol2qm74	1546	40	7	7	CD
cord-015021-pol2qm74	1546	41	,	,	,
cord-015021-pol2qm74	1546	42	P<0.001	P<0.001	NNP
cord-015021-pol2qm74	1546	43	)	)	-RRB-
cord-015021-pol2qm74	1546	44	.	.	.
cord-015021-pol2qm74	1547	1	Transfused	transfuse	VBN
cord-015021-pol2qm74	1547	2	animals	animal	NNS
cord-015021-pol2qm74	1547	3	pretreated	pretreate	VBD
cord-015021-pol2qm74	1547	4	with	with	IN
cord-015021-pol2qm74	1547	5	MTP	MTP	NNP
cord-015021-pol2qm74	1547	6	-	-	HYPH
cord-015021-pol2qm74	1547	7	PE	PE	NNP
cord-015021-pol2qm74	1547	8	encapsulated	encapsulate	VBN
cord-015021-pol2qm74	1547	9	Liposomes	Liposomes	NNP
cord-015021-pol2qm74	1547	10	showed	show	VBD
cord-015021-pol2qm74	1547	11	a	a	DT
cord-015021-pol2qm74	1547	12	significant	significant	JJ
cord-015021-pol2qm74	1547	13	improvement	improvement	NN
cord-015021-pol2qm74	1547	14	of	of	IN
cord-015021-pol2qm74	1547	15	their	-PRON-	PRP$
cord-015021-pol2qm74	1547	16	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	1547	17	bursting	burst	VBG
cord-015021-pol2qm74	1547	18	pressure	pressure	NN
cord-015021-pol2qm74	1547	19	(	(	-LRB-
cord-015021-pol2qm74	1547	20	93	93	CD
cord-015021-pol2qm74	1547	21	+	+	SYM
cord-015021-pol2qm74	1547	22	9	9	CD
cord-015021-pol2qm74	1547	23	,	,	,
cord-015021-pol2qm74	1547	24	P<0.001	P<0.001	NNP
cord-015021-pol2qm74	1547	25	vs	vs	IN
cord-015021-pol2qm74	1547	26	transfusion	transfusion	NN
cord-015021-pol2qm74	1547	27	)	)	-RRB-
cord-015021-pol2qm74	1547	28	.	.	.
cord-015021-pol2qm74	1548	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	1548	2	with	with	IN
cord-015021-pol2qm74	1548	3	MTP	MTP	NNP
cord-015021-pol2qm74	1548	4	-	-	HYPH
cord-015021-pol2qm74	1548	5	PE	PE	NNP
cord-015021-pol2qm74	1548	6	encapsulated	encapsulate	VBN
cord-015021-pol2qm74	1548	7	Liposomes	Liposomes	NNP
cord-015021-pol2qm74	1548	8	decreased	decrease	VBD
cord-015021-pol2qm74	1548	9	significantly	significantly	RB
cord-015021-pol2qm74	1548	10	the	the	DT
cord-015021-pol2qm74	1548	11	incidence	incidence	NN
cord-015021-pol2qm74	1548	12	of	of	IN
cord-015021-pol2qm74	1548	13	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	1548	14	abscesses	abscess	NNS
cord-015021-pol2qm74	1548	15	in	in	IN
cord-015021-pol2qm74	1548	16	transfused	transfuse	VBN
cord-015021-pol2qm74	1548	17	animals	animal	NNS
cord-015021-pol2qm74	1548	18	(	(	-LRB-
cord-015021-pol2qm74	1548	19	from	from	IN
cord-015021-pol2qm74	1548	20	90	90	CD
cord-015021-pol2qm74	1548	21	%	%	NN
cord-015021-pol2qm74	1548	22	in	in	IN
cord-015021-pol2qm74	1548	23	ileum	ileum	NN
cord-015021-pol2qm74	1548	24	on	on	IN
cord-015021-pol2qm74	1548	25	day	day	NN
cord-015021-pol2qm74	1548	26	3	3	CD
cord-015021-pol2qm74	1548	27	to	to	TO
cord-015021-pol2qm74	1548	28	20	20	CD
cord-015021-pol2qm74	1548	29	%	%	NN
cord-015021-pol2qm74	1548	30	,	,	,
cord-015021-pol2qm74	1548	31	P<0.001	P<0.001	NNP
cord-015021-pol2qm74	1548	32	)	)	-RRB-
cord-015021-pol2qm74	1548	33	.	.	.
cord-015021-pol2qm74	1549	1	Conclusions	Conclusions	NNPS
cord-015021-pol2qm74	1549	2	Preactivation	Preactivation	NNP
cord-015021-pol2qm74	1549	3	of	of	IN
cord-015021-pol2qm74	1549	4	regional	regional	JJ
cord-015021-pol2qm74	1549	5	macrophges	macrophge	NNS
cord-015021-pol2qm74	1549	6	by	by	IN
cord-015021-pol2qm74	1549	7	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	1549	8	administration	administration	NN
cord-015021-pol2qm74	1549	9	of	of	IN
cord-015021-pol2qm74	1549	10	MTP	MTP	NNP
cord-015021-pol2qm74	1549	11	-	-	HYPH
cord-015021-pol2qm74	1549	12	PE	PE	NNP
cord-015021-pol2qm74	1549	13	encapsulated	encapsulate	VBN
cord-015021-pol2qm74	1549	14	Liposomes	Liposomes	NNP
cord-015021-pol2qm74	1549	15	prevents	prevent	VBZ
cord-015021-pol2qm74	1549	16	the	the	DT
cord-015021-pol2qm74	1549	17	detrimental	detrimental	JJ
cord-015021-pol2qm74	1549	18	effects	effect	NNS
cord-015021-pol2qm74	1549	19	of	of	IN
cord-015021-pol2qm74	1549	20	transfusions	transfusion	NNS
cord-015021-pol2qm74	1549	21	on	on	IN
cord-015021-pol2qm74	1549	22	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	1549	23	repair	repair	NN
cord-015021-pol2qm74	1549	24	and	and	CC
cord-015021-pol2qm74	1549	25	reduces	reduce	VBZ
cord-015021-pol2qm74	1549	26	the	the	DT
cord-015021-pol2qm74	1549	27	incidence	incidence	NN
cord-015021-pol2qm74	1549	28	of	of	IN
cord-015021-pol2qm74	1549	29	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	1549	30	sepsis	sepsis	NN
cord-015021-pol2qm74	1549	31	.	.	.
cord-015021-pol2qm74	1550	1	Academic	Academic	NNP
cord-015021-pol2qm74	1550	2	Hospital	Hospital	NNP
cord-015021-pol2qm74	1550	3	Nijmegen	Nijmegen	NNP
cord-015021-pol2qm74	1550	4	,	,	,
cord-015021-pol2qm74	1550	5	Dept	Dept	NNP
cord-015021-pol2qm74	1550	6	of	of	IN
cord-015021-pol2qm74	1550	7	General	General	NNP
cord-015021-pol2qm74	1550	8	Surgery	Surgery	NNP
cord-015021-pol2qm74	1550	9	,	,	,
cord-015021-pol2qm74	1550	10	PB	PB	NNP
cord-015021-pol2qm74	1550	11	910	910	CD
cord-015021-pol2qm74	1550	12	I	i	NN
cord-015021-pol2qm74	1550	13	,	,	,
cord-015021-pol2qm74	1550	14	6500	6500	CD
cord-015021-pol2qm74	1550	15	HB	HB	NNP
cord-015021-pol2qm74	1550	16	Nijmegen	Nijmegen	NNP
cord-015021-pol2qm74	1550	17	,	,	,
cord-015021-pol2qm74	1550	18	The	the	DT
cord-015021-pol2qm74	1550	19	Netherlands	Netherlands	NNP
cord-015021-pol2qm74	1550	20	.	.	.
cord-015021-pol2qm74	1551	1	LEUKEMIA	LEUKEMIA	NNP
cord-015021-pol2qm74	1551	2	CELL	cell	NN
cord-015021-pol2qm74	1551	3	LINE	line	NN
cord-015021-pol2qm74	1551	4	,	,	,
cord-015021-pol2qm74	1551	5	TEIP-1	TEIP-1	NNP
cord-015021-pol2qm74	1551	6	.	.	.
cord-015021-pol2qm74	1552	1	Robin	Robin	NNP
cord-015021-pol2qm74	1552	2	S.	S.	NNP
cord-015021-pol2qm74	1552	3	Wa	Wa	NNP
cord-015021-pol2qm74	1552	4	,	,	,
cord-015021-pol2qm74	1552	5	gner	gner	NNP
cord-015021-pol2qm74	1552	6	*	*	NFP
cord-015021-pol2qm74	1552	7	,	,	,
cord-015021-pol2qm74	1552	8	Perry	Perry	NNP
cord-015021-pol2qm74	1552	9	V.	V.	NNP
cord-015021-pol2qm74	1552	10	Halushka	Halushka	NNP
cord-015021-pol2qm74	1552	11	"	"	''
cord-015021-pol2qm74	1553	1	~	~	NFP
cord-015021-pol2qm74	1553	2	,	,	,
cord-015021-pol2qm74	1553	3	and	and	CC
cord-015021-pol2qm74	1553	4	James	James	NNP
cord-015021-pol2qm74	1553	5	A.	a.	NN
cord-015021-pol2qm74	1553	6	Cook	Cook	NNP
cord-015021-pol2qm74	1553	7	*	*	NFP
cord-015021-pol2qm74	1553	8	,	,	,
cord-015021-pol2qm74	1553	9	Departments	Departments	NNPS
cord-015021-pol2qm74	1553	10	of	of	IN
cord-015021-pol2qm74	1553	11	Physiology	Physiology	NNP
cord-015021-pol2qm74	1553	12	,	,	,
cord-015021-pol2qm74	1553	13	Pharmacology	Pharmacology	NNP
cord-015021-pol2qm74	1553	14	"	"	``
cord-015021-pol2qm74	1553	15	l	l	NN
cord-015021-pol2qm74	1553	16	"	"	''
cord-015021-pol2qm74	1553	17	and	and	CC
cord-015021-pol2qm74	1553	18	Medicine	Medicine	NNP
cord-015021-pol2qm74	1553	19	"	"	''
cord-015021-pol2qm74	1553	20	t	t	NNP
cord-015021-pol2qm74	1553	21	,	,	,
cord-015021-pol2qm74	1553	22	Medical	Medical	NNP
cord-015021-pol2qm74	1553	23	University	University	NNP
cord-015021-pol2qm74	1553	24	of	of	IN
cord-015021-pol2qm74	1553	25	South	South	NNP
cord-015021-pol2qm74	1553	26	Carolina	Carolina	NNP
cord-015021-pol2qm74	1553	27	,	,	,
cord-015021-pol2qm74	1553	28	Charleston	Charleston	NNP
cord-015021-pol2qm74	1553	29	,	,	,
cord-015021-pol2qm74	1553	30	S.C.	South Carolina	NNP
cord-015021-pol2qm74	1553	31	29425	29425	CD
cord-015021-pol2qm74	1553	32	.	.	.
cord-015021-pol2qm74	1554	1	Adherence	adherence	NN
cord-015021-pol2qm74	1554	2	of	of	IN
cord-015021-pol2qm74	1554	3	monoeytes	monoeyte	NNS
cord-015021-pol2qm74	1554	4	to	to	TO
cord-015021-pol2qm74	1554	5	endothelium	endothelium	NN
cord-015021-pol2qm74	1554	6	and	and	CC
cord-015021-pol2qm74	1554	7	extracella	extracella	NNP
cord-015021-pol2qm74	1554	8	/	/	SYM
cord-015021-pol2qm74	1554	9	ar	ar	NNP
cord-015021-pol2qm74	1554	10	matrix	matrix	NN
cord-015021-pol2qm74	1554	11	proteins	protein	NNS
cord-015021-pol2qm74	1554	12	is	be	VBZ
cord-015021-pol2qm74	1554	13	essential	essential	JJ
cord-015021-pol2qm74	1554	14	for	for	IN
cord-015021-pol2qm74	1554	15	accumulation	accumulation	NN
cord-015021-pol2qm74	1554	16	at	at	IN
cord-015021-pol2qm74	1554	17	sites	site	NNS
cord-015021-pol2qm74	1554	18	of	of	IN
cord-015021-pol2qm74	1554	19	inflammation	inflammation	NN
cord-015021-pol2qm74	1554	20	.	.	.
cord-015021-pol2qm74	1555	1	TXA2	TXA2	NNP
cord-015021-pol2qm74	1555	2	,	,	,
cord-015021-pol2qm74	1555	3	an	an	DT
cord-015021-pol2qm74	1555	4	arachidonic	arachidonic	JJ
cord-015021-pol2qm74	1555	5	acid	acid	NN
cord-015021-pol2qm74	1555	6	metabolite	metabolite	NN
cord-015021-pol2qm74	1555	7	,	,	,
cord-015021-pol2qm74	1555	8	inhibits	inhibit	VBZ
cord-015021-pol2qm74	1555	9	human	human	JJ
cord-015021-pol2qm74	1555	10	monocyte	monocyte	NNP
cord-015021-pol2qm74	1555	11	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	1555	12	responses	response	NNS
cord-015021-pol2qm74	1555	13	suggesting	suggest	VBG
cord-015021-pol2qm74	1555	14	that	that	IN
cord-015021-pol2qm74	1555	15	TXA	TXA	NNP
cord-015021-pol2qm74	1555	16	2	2	CD
cord-015021-pol2qm74	1555	17	may	may	MD
cord-015021-pol2qm74	1555	18	alter	alter	VB
cord-015021-pol2qm74	1555	19	monocyte	monocyte	JJ
cord-015021-pol2qm74	1555	20	adhesiveness	adhesiveness	NN
cord-015021-pol2qm74	1555	21	.	.	.
cord-015021-pol2qm74	1556	1	We	-PRON-	PRP
cord-015021-pol2qm74	1556	2	selected	select	VBD
cord-015021-pol2qm74	1556	3	the	the	DT
cord-015021-pol2qm74	1556	4	THP-1	THP-1	NNP
cord-015021-pol2qm74	1556	5	cell	cell	NN
cord-015021-pol2qm74	1556	6	line	line	NN
cord-015021-pol2qm74	1556	7	,	,	,
cord-015021-pol2qm74	1556	8	a	a	DT
cord-015021-pol2qm74	1556	9	human	human	JJ
cord-015021-pol2qm74	1556	10	monocytic	monocytic	JJ
cord-015021-pol2qm74	1556	11	leukemia	leukemia	NN
cord-015021-pol2qm74	1556	12	cell	cell	NN
cord-015021-pol2qm74	1556	13	line	line	NN
cord-015021-pol2qm74	1556	14	to	to	TO
cord-015021-pol2qm74	1556	15	further	further	RB
cord-015021-pol2qm74	1556	16	investigate	investigate	VB
cord-015021-pol2qm74	1556	17	the	the	DT
cord-015021-pol2qm74	1556	18	effect	effect	NN
cord-015021-pol2qm74	1556	19	of	of	IN
cord-015021-pol2qm74	1556	20	TXA	TXA	NNP
cord-015021-pol2qm74	1556	21	2	2	CD
cord-015021-pol2qm74	1556	22	on	on	IN
cord-015021-pol2qm74	1556	23	adhesion	adhesion	NN
cord-015021-pol2qm74	1556	24	.	.	.
cord-015021-pol2qm74	1557	1	We	-PRON-	PRP
cord-015021-pol2qm74	1557	2	tested	test	VBD
cord-015021-pol2qm74	1557	3	the	the	DT
cord-015021-pol2qm74	1557	4	hypothesis	hypothesis	NN
cord-015021-pol2qm74	1557	5	that	that	IN
cord-015021-pol2qm74	1557	6	TXA	TXA	NNP
cord-015021-pol2qm74	1557	7	2	2	CD
cord-015021-pol2qm74	1557	8	alters	alter	VBZ
cord-015021-pol2qm74	1557	9	LPSinduced	lpsinduced	JJ
cord-015021-pol2qm74	1557	10	adhesion	adhesion	NN
cord-015021-pol2qm74	1557	11	of	of	IN
cord-015021-pol2qm74	1557	12	THP-1	THP-1	NNP
cord-015021-pol2qm74	1557	13	cells	cell	NNS
cord-015021-pol2qm74	1557	14	and	and	CC
cord-015021-pol2qm74	1557	15	that	that	IN
cord-015021-pol2qm74	1557	16	TXA	TXA	NNP
cord-015021-pol2qm74	1557	17	2	2	CD
cord-015021-pol2qm74	1557	18	exerts	exert	VBZ
cord-015021-pol2qm74	1557	19	its	-PRON-	PRP$
cord-015021-pol2qm74	1557	20	effect	effect	NN
cord-015021-pol2qm74	1557	21	on	on	IN
cord-015021-pol2qm74	1557	22	adhesion	adhesion	NN
cord-015021-pol2qm74	1557	23	via	via	IN
cord-015021-pol2qm74	1557	24	a	a	DT
cord-015021-pol2qm74	1557	25	cAMP	camp	NN
cord-015021-pol2qm74	1557	26	dependent	dependent	JJ
cord-015021-pol2qm74	1557	27	mechanism	mechanism	NN
cord-015021-pol2qm74	1557	28	.	.	.
cord-015021-pol2qm74	1558	1	THP	THP	NNP
cord-015021-pol2qm74	1558	2	-	-	HYPH
cord-015021-pol2qm74	1558	3	I	-PRON-	PRP
cord-015021-pol2qm74	1558	4	cells	cell	NNS
cord-015021-pol2qm74	1558	5	were	be	VBD
cord-015021-pol2qm74	1558	6	exposed	expose	VBN
cord-015021-pol2qm74	1558	7	to	to	IN
cord-015021-pol2qm74	1558	8	S.	S.	NNP
cord-015021-pol2qm74	1558	9	enteritidis	enteritidis	NN
cord-015021-pol2qm74	1558	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1558	11	(	(	-LRB-
cord-015021-pol2qm74	1558	12	lp.g	lp.g	NNP
cord-015021-pol2qm74	1558	13	/	/	SYM
cord-015021-pol2qm74	1558	14	ml	ml	NN
cord-015021-pol2qm74	1558	15	)	)	-RRB-
cord-015021-pol2qm74	1559	1	_	_	NNP
cord-015021-pol2qm74	1560	1	+	+	CC
cord-015021-pol2qm74	1560	2	the	the	DT
cord-015021-pol2qm74	1560	3	cyelooxygenase	cyelooxygenase	JJ
cord-015021-pol2qm74	1560	4	inhibitor	inhibitor	NN
cord-015021-pol2qm74	1560	5	lndomethacin	lndomethacin	NNS
cord-015021-pol2qm74	1560	6	(	(	-LRB-
cord-015021-pol2qm74	1560	7	IN	in	IN
cord-015021-pol2qm74	1560	8	)	)	-RRB-
cord-015021-pol2qm74	1560	9	,	,	,
cord-015021-pol2qm74	1560	10	the	the	DT
cord-015021-pol2qm74	1560	11	TXA	TXA	NNP
cord-015021-pol2qm74	1560	12	2	2	CD
cord-015021-pol2qm74	1560	13	mimetic	mimetic	NN
cord-015021-pol2qm74	1560	14	I	I	NNP
cord-015021-pol2qm74	1560	15	-	-	HYPH
cord-015021-pol2qm74	1560	16	BOP	BOP	NNP
cord-015021-pol2qm74	1560	17	(	(	-LRB-
cord-015021-pol2qm74	1560	18	0.11.tM	0.11.tm	CD
cord-015021-pol2qm74	1560	19	,	,	,
cord-015021-pol2qm74	1560	20	)	)	-RRB-
cord-015021-pol2qm74	1560	21	or	or	CC
cord-015021-pol2qm74	1560	22	TXA	TXA	NNP
cord-015021-pol2qm74	1560	23	2	2	CD
cord-015021-pol2qm74	1560	24	receptor	receptor	NN
cord-015021-pol2qm74	1560	25	antagonists	antagonist	NNS
cord-015021-pol2qm74	1561	1	BMS180291	BMS180291	NNP
cord-015021-pol2qm74	1561	2	and	and	CC
cord-015021-pol2qm74	1561	3	L657925	L657925	NNP
cord-015021-pol2qm74	1561	4	(	(	-LRB-
cord-015021-pol2qm74	1561	5	10~M	10~m	CD
cord-015021-pol2qm74	1561	6	)	)	-RRB-
cord-015021-pol2qm74	1561	7	.	.	.
cord-015021-pol2qm74	1562	1	Cells	cell	NNS
cord-015021-pol2qm74	1562	2	were	be	VBD
cord-015021-pol2qm74	1562	3	allowed	allow	VBN
cord-015021-pol2qm74	1562	4	to	to	TO
cord-015021-pol2qm74	1562	5	adhere	adhere	VB
cord-015021-pol2qm74	1562	6	for	for	IN
cord-015021-pol2qm74	1562	7	24	24	CD
cord-015021-pol2qm74	1562	8	hours	hour	NNS
cord-015021-pol2qm74	1562	9	and	and	CC
cord-015021-pol2qm74	1562	10	adherent	adherent	JJ
cord-015021-pol2qm74	1562	11	protein/	protein/	XX
cord-015021-pol2qm74	1563	1	well	well	UH
cord-015021-pol2qm74	1563	2	was	be	VBD
cord-015021-pol2qm74	1563	3	determined	determine	VBN
cord-015021-pol2qm74	1563	4	.	.	.
cord-015021-pol2qm74	1564	1	LPS	LPS	NNP
cord-015021-pol2qm74	1564	2	-	-	HYPH
cord-015021-pol2qm74	1564	3	induced	induce	VBN
cord-015021-pol2qm74	1564	4	a	a	DT
cord-015021-pol2qm74	1564	5	significant	significant	JJ
cord-015021-pol2qm74	1564	6	(	(	-LRB-
cord-015021-pol2qm74	1564	7	p<0.05;n=7	p<0.05;n=7	NN
cord-015021-pol2qm74	1564	8	)	)	-RRB-
cord-015021-pol2qm74	1564	9	increase	increase	VB
cord-015021-pol2qm74	1564	10	in	in	IN
cord-015021-pol2qm74	1564	11	adherence	adherence	NN
cord-015021-pol2qm74	1564	12	of	of	IN
cord-015021-pol2qm74	1564	13	THP-1	THP-1	NNP
cord-015021-pol2qm74	1564	14	cells	cell	NNS
cord-015021-pol2qm74	1564	15	(	(	-LRB-
cord-015021-pol2qm74	1564	16	Basal	Basal	NNP
cord-015021-pol2qm74	1564	17	,	,	,
cord-015021-pol2qm74	1564	18	2.4	2.4	CD
cord-015021-pol2qm74	1564	19	+	+	SYM
cord-015021-pol2qm74	1564	20	0.85gg	0.85gg	CD
cord-015021-pol2qm74	1564	21	protein/	protein/	ADD
cord-015021-pol2qm74	1565	1	well	well	UH
cord-015021-pol2qm74	1565	2	;	;	:
cord-015021-pol2qm74	1565	3	LPS	LPS	NNP
cord-015021-pol2qm74	1565	4	,	,	,
cord-015021-pol2qm74	1566	1	20.4+_6.0p.g	20.4+_6.0p.g	CD
cord-015021-pol2qm74	1566	2	protein	protein	NN
cord-015021-pol2qm74	1566	3	/	/	SYM
cord-015021-pol2qm74	1566	4	well	well	RB
cord-015021-pol2qm74	1566	5	)	)	-RRB-
cord-015021-pol2qm74	1566	6	.	.	.
cord-015021-pol2qm74	1567	1	The	the	DT
cord-015021-pol2qm74	1567	2	amino	amino	NN
cord-015021-pol2qm74	1567	3	acid	acid	NN
cord-015021-pol2qm74	1567	4	glutamine	glutamine	NN
cord-015021-pol2qm74	1567	5	is	be	VBZ
cord-015021-pol2qm74	1567	6	an	an	DT
cord-015021-pol2qm74	1567	7	essential	essential	JJ
cord-015021-pol2qm74	1567	8	compound	compound	NN
cord-015021-pol2qm74	1567	9	for	for	IN
cord-015021-pol2qm74	1567	10	synthesis	synthesis	NN
cord-015021-pol2qm74	1567	11	of	of	IN
cord-015021-pol2qm74	1567	12	purine	purine	NNP
cord-015021-pol2qm74	1567	13	and	and	CC
cord-015021-pol2qm74	1567	14	pyrimidine	pyrimidine	JJ
cord-015021-pol2qm74	1567	15	basis	basis	NN
cord-015021-pol2qm74	1567	16	and	and	CC
cord-015021-pol2qm74	1567	17	therefore	therefore	RB
cord-015021-pol2qm74	1567	18	necessary	necessary	JJ
cord-015021-pol2qm74	1567	19	for	for	IN
cord-015021-pol2qm74	1567	20	RNA	RNA	NNP
cord-015021-pol2qm74	1567	21	-	-	:
cord-015021-pol2qm74	1567	22	and	and	CC
cord-015021-pol2qm74	1567	23	DNA	dna	NN
cord-015021-pol2qm74	1567	24	synthesis	synthesis	NN
cord-015021-pol2qm74	1567	25	.	.	.
cord-015021-pol2qm74	1568	1	In	in	IN
cord-015021-pol2qm74	1568	2	human	human	JJ
cord-015021-pol2qm74	1568	3	plasma	plasma	NN
cord-015021-pol2qm74	1568	4	the	the	DT
cord-015021-pol2qm74	1568	5	concentration	concentration	NN
cord-015021-pol2qm74	1568	6	of	of	IN
cord-015021-pol2qm74	1568	7	glutamine	glutamine	NN
cord-015021-pol2qm74	1568	8	is	be	VBZ
cord-015021-pol2qm74	1568	9	between	between	IN
cord-015021-pol2qm74	1568	10	0.5	0.5	CD
cord-015021-pol2qm74	1568	11	-0.6	-0.6	CD
cord-015021-pol2qm74	1568	12	mM	mm	NN
cord-015021-pol2qm74	1568	13	,	,	,
cord-015021-pol2qm74	1568	14	and	and	CC
cord-015021-pol2qm74	1568	15	is	be	VBZ
cord-015021-pol2qm74	1568	16	reduced	reduce	VBN
cord-015021-pol2qm74	1568	17	in	in	IN
cord-015021-pol2qm74	1568	18	septic	septic	JJ
cord-015021-pol2qm74	1568	19	patients	patient	NNS
cord-015021-pol2qm74	1568	20	up	up	RP
cord-015021-pol2qm74	1568	21	to	to	TO
cord-015021-pol2qm74	1568	22	80	80	CD
cord-015021-pol2qm74	1568	23	%	%	NN
cord-015021-pol2qm74	1568	24	(	(	-LRB-
cord-015021-pol2qm74	1568	25	0.1	0.1	CD
cord-015021-pol2qm74	1568	26	-0.2	-0.2	SYM
cord-015021-pol2qm74	1568	27	mM	mm	CD
cord-015021-pol2qm74	1568	28	)	)	-RRB-
cord-015021-pol2qm74	1568	29	.	.	.
cord-015021-pol2qm74	1569	1	Monocytes	monocyte	NNS
cord-015021-pol2qm74	1569	2	play	play	VBP
cord-015021-pol2qm74	1569	3	a	a	DT
cord-015021-pol2qm74	1569	4	central	central	JJ
cord-015021-pol2qm74	1569	5	part	part	NN
cord-015021-pol2qm74	1569	6	in	in	IN
cord-015021-pol2qm74	1569	7	the	the	DT
cord-015021-pol2qm74	1569	8	inunune	inunune	JJ
cord-015021-pol2qm74	1569	9	system	system	NN
cord-015021-pol2qm74	1569	10	and	and	CC
cord-015021-pol2qm74	1569	11	it	-PRON-	PRP
cord-015021-pol2qm74	1569	12	was	be	VBD
cord-015021-pol2qm74	1569	13	of	of	IN
cord-015021-pol2qm74	1569	14	interest	interest	NN
cord-015021-pol2qm74	1569	15	,	,	,
cord-015021-pol2qm74	1569	16	whether	whether	IN
cord-015021-pol2qm74	1569	17	glutamine	glutamine	NN
cord-015021-pol2qm74	1569	18	is	be	VBZ
cord-015021-pol2qm74	1569	19	involved	involve	VBN
cord-015021-pol2qm74	1569	20	in	in	IN
cord-015021-pol2qm74	1569	21	the	the	DT
cord-015021-pol2qm74	1569	22	modulation	modulation	NN
cord-015021-pol2qm74	1569	23	of	of	IN
cord-015021-pol2qm74	1569	24	cell	cell	NN
cord-015021-pol2qm74	1569	25	surface	surface	NN
cord-015021-pol2qm74	1569	26	markers	marker	NNS
cord-015021-pol2qm74	1569	27	and	and	CC
cord-015021-pol2qm74	1569	28	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	1569	29	of	of	IN
cord-015021-pol2qm74	1569	30	these	these	DT
cord-015021-pol2qm74	1569	31	cells	cell	NNS
cord-015021-pol2qm74	1569	32	.	.	.
cord-015021-pol2qm74	1570	1	Human	human	JJ
cord-015021-pol2qm74	1570	2	peripheral	peripheral	JJ
cord-015021-pol2qm74	1570	3	blood	blood	NN
cord-015021-pol2qm74	1570	4	mononuclear	mononuclear	FW
cord-015021-pol2qm74	1570	5	ceils	ceil	NNS
cord-015021-pol2qm74	1570	6	were	be	VBD
cord-015021-pol2qm74	1570	7	obtained	obtain	VBN
cord-015021-pol2qm74	1570	8	from	from	IN
cord-015021-pol2qm74	1570	9	500	500	CD
cord-015021-pol2qm74	1570	10	ml	ml	XX
cord-015021-pol2qm74	1570	11	heparinized	heparinize	VBN
cord-015021-pol2qm74	1570	12	blood	blood	NN
cord-015021-pol2qm74	1570	13	of	of	IN
cord-015021-pol2qm74	1570	14	apparently	apparently	RB
cord-015021-pol2qm74	1570	15	healthy	healthy	JJ
cord-015021-pol2qm74	1570	16	donors	donor	NNS
cord-015021-pol2qm74	1570	17	by	by	IN
cord-015021-pol2qm74	1570	18	Ficoll	Ficoll	NNP
cord-015021-pol2qm74	1570	19	-	-	HYPH
cord-015021-pol2qm74	1570	20	Paque	paque	JJ
cord-015021-pol2qm74	1570	21	density	density	NN
cord-015021-pol2qm74	1570	22	gradient	gradient	NN
cord-015021-pol2qm74	1570	23	and	and	CC
cord-015021-pol2qm74	1570	24	isolated	isolate	VBN
cord-015021-pol2qm74	1570	25	by	by	IN
cord-015021-pol2qm74	1570	26	counterflow	counterflow	NN
cord-015021-pol2qm74	1570	27	elutriation	elutriation	NN
cord-015021-pol2qm74	1570	28	.	.	.
cord-015021-pol2qm74	1571	1	The	the	DT
cord-015021-pol2qm74	1571	2	puritiy	puritiy	NNS
cord-015021-pol2qm74	1571	3	was	be	VBD
cord-015021-pol2qm74	1571	4	more	more	JJR
cord-015021-pol2qm74	1571	5	than	than	IN
cord-015021-pol2qm74	1571	6	90	90	CD
cord-015021-pol2qm74	1571	7	%	%	NN
cord-015021-pol2qm74	1571	8	.	.	.
cord-015021-pol2qm74	1572	1	Subsequently	subsequently	RB
cord-015021-pol2qm74	1572	2	cells	cell	NNS
cord-015021-pol2qm74	1572	3	were	be	VBD
cord-015021-pol2qm74	1572	4	cultured	culture	VBN
cord-015021-pol2qm74	1572	5	in	in	IN
cord-015021-pol2qm74	1572	6	phenolred	phenolre	VBN
cord-015021-pol2qm74	1572	7	-	-	HYPH
cord-015021-pol2qm74	1572	8	free	free	JJ
cord-015021-pol2qm74	1572	9	RPMI	RPMI	NNP
cord-015021-pol2qm74	1572	10	1640	1640	CD
cord-015021-pol2qm74	1572	11	medium	medium	NN
cord-015021-pol2qm74	1572	12	with	with	IN
cord-015021-pol2qm74	1572	13	various	various	JJ
cord-015021-pol2qm74	1572	14	concentrations	concentration	NNS
cord-015021-pol2qm74	1572	15	of	of	IN
cord-015021-pol2qm74	1572	16	glutamine	glutamine	NN
cord-015021-pol2qm74	1572	17	(	(	-LRB-
cord-015021-pol2qm74	1572	18	0.05	0.05	CD
cord-015021-pol2qm74	1572	19	,	,	,
cord-015021-pol2qm74	1572	20	0.1	0.1	CD
cord-015021-pol2qm74	1572	21	,	,	,
cord-015021-pol2qm74	1572	22	0.2	0.2	CD
cord-015021-pol2qm74	1572	23	,	,	,
cord-015021-pol2qm74	1572	24	0.3	0.3	CD
cord-015021-pol2qm74	1572	25	,	,	,
cord-015021-pol2qm74	1572	26	0.6	0.6	CD
cord-015021-pol2qm74	1572	27	,	,	,
cord-015021-pol2qm74	1572	28	1	1	CD
cord-015021-pol2qm74	1572	29	,	,	,
cord-015021-pol2qm74	1572	30	2	2	CD
cord-015021-pol2qm74	1572	31	mM	mm	CD
cord-015021-pol2qm74	1572	32	)	)	-RRB-
cord-015021-pol2qm74	1572	33	in	in	IN
cord-015021-pol2qm74	1572	34	teflon	teflon	NN
cord-015021-pol2qm74	1572	35	-	-	HYPH
cord-015021-pol2qm74	1572	36	fluorinated	fluorinate	VBN
cord-015021-pol2qm74	1572	37	ethylene	ethylene	NN
cord-015021-pol2qm74	1572	38	propylene	propylene	NN
cord-015021-pol2qm74	1572	39	bottles	bottle	NNS
cord-015021-pol2qm74	1572	40	to	to	TO
cord-015021-pol2qm74	1572	41	exclude	exclude	VB
cord-015021-pol2qm74	1572	42	cell	cell	NN
cord-015021-pol2qm74	1572	43	adhesion	adhesion	NN
cord-015021-pol2qm74	1572	44	and	and	CC
cord-015021-pol2qm74	1572	45	possible	possible	JJ
cord-015021-pol2qm74	1572	46	cell	cell	NN
cord-015021-pol2qm74	1572	47	activation	activation	NN
cord-015021-pol2qm74	1572	48	.	.	.
cord-015021-pol2qm74	1573	1	Aider	Aider	NNP
cord-015021-pol2qm74	1573	2	seven	seven	CD
cord-015021-pol2qm74	1573	3	days	day	NNS
cord-015021-pol2qm74	1573	4	culture	culture	NN
cord-015021-pol2qm74	1573	5	,	,	,
cord-015021-pol2qm74	1573	6	cell	cell	NN
cord-015021-pol2qm74	1573	7	viabilty	viabilty	NN
cord-015021-pol2qm74	1573	8	was	be	VBD
cord-015021-pol2qm74	1573	9	determined	determine	VBN
cord-015021-pol2qm74	1573	10	by	by	IN
cord-015021-pol2qm74	1573	11	trepan	trepan	NNP
cord-015021-pol2qm74	1573	12	blue	blue	JJ
cord-015021-pol2qm74	1573	13	exclusion	exclusion	NN
cord-015021-pol2qm74	1573	14	and	and	CC
cord-015021-pol2qm74	1573	15	varied	vary	VBN
cord-015021-pol2qm74	1573	16	between	between	IN
cord-015021-pol2qm74	1573	17	70	70	CD
cord-015021-pol2qm74	1573	18	and	and	CC
cord-015021-pol2qm74	1573	19	90	90	CD
cord-015021-pol2qm74	1573	20	%	%	NN
cord-015021-pol2qm74	1573	21	,	,	,
cord-015021-pol2qm74	1573	22	independent	independent	JJ
cord-015021-pol2qm74	1573	23	of	of	IN
cord-015021-pol2qm74	1573	24	glutamine	glutamine	NN
cord-015021-pol2qm74	1573	25	concentrations	concentration	NNS
cord-015021-pol2qm74	1573	26	.	.	.
cord-015021-pol2qm74	1574	1	Cell	cell	NN
cord-015021-pol2qm74	1574	2	surface	surface	NN
cord-015021-pol2qm74	1574	3	markers	marker	NNS
cord-015021-pol2qm74	1574	4	were	be	VBD
cord-015021-pol2qm74	1574	5	detected	detect	VBN
cord-015021-pol2qm74	1574	6	by	by	IN
cord-015021-pol2qm74	1574	7	flow	flow	NN
cord-015021-pol2qm74	1574	8	cytometry	cytometry	NN
cord-015021-pol2qm74	1574	9	,	,	,
cord-015021-pol2qm74	1574	10	noaspecifie	noaspecifie	NNP
cord-015021-pol2qm74	1574	11	phagoeytosis	phagoeytosis	NNP
cord-015021-pol2qm74	1574	12	was	be	VBD
cord-015021-pol2qm74	1574	13	measured	measure	VBN
cord-015021-pol2qm74	1574	14	with	with	IN
cord-015021-pol2qm74	1574	15	latex	latex	NN
cord-015021-pol2qm74	1574	16	beads	bead	NNS
cord-015021-pol2qm74	1574	17	and	and	CC
cord-015021-pol2qm74	1574	18	specific	specific	JJ
cord-015021-pol2qm74	1574	19	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	1574	20	with	with	IN
cord-015021-pol2qm74	1574	21	opsonizied	opsonizied	JJ
cord-015021-pol2qm74	1574	22	E.eoli	E.eoli	NNS
cord-015021-pol2qm74	1574	23	using	use	VBG
cord-015021-pol2qm74	1574	24	a	a	DT
cord-015021-pol2qm74	1574	25	FACScan	facscan	NN
cord-015021-pol2qm74	1574	26	.	.	.
cord-015021-pol2qm74	1575	1	Lower	low	JJR
cord-015021-pol2qm74	1575	2	concentrations	concentration	NNS
cord-015021-pol2qm74	1575	3	of	of	IN
cord-015021-pol2qm74	1575	4	glutamine	glutamine	NN
cord-015021-pol2qm74	1575	5	decreased	decrease	VBD
cord-015021-pol2qm74	1575	6	the	the	DT
cord-015021-pol2qm74	1575	7	expression	expression	NN
cord-015021-pol2qm74	1575	8	of	of	IN
cord-015021-pol2qm74	1575	9	HLA	HLA	NNP
cord-015021-pol2qm74	1575	10	-	-	HYPH
cord-015021-pol2qm74	1575	11	DR	DR	NNP
cord-015021-pol2qm74	1575	12	and	and	CC
cord-015021-pol2qm74	1575	13	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1575	14	/	/	SYM
cord-015021-pol2qm74	1575	15	CD54	CD54	NNP
cord-015021-pol2qm74	1575	16	on	on	IN
cord-015021-pol2qm74	1575	17	monocytes	monocyte	NNS
cord-015021-pol2qm74	1575	18	in	in	IN
cord-015021-pol2qm74	1575	19	a	a	DT
cord-015021-pol2qm74	1575	20	dose	dose	NN
cord-015021-pol2qm74	1575	21	-	-	HYPH
cord-015021-pol2qm74	1575	22	dependent	dependent	JJ
cord-015021-pol2qm74	1575	23	manner	manner	NN
cord-015021-pol2qm74	1575	24	.	.	.
cord-015021-pol2qm74	1576	1	The	the	DT
cord-015021-pol2qm74	1576	2	receptor	receptor	NN
cord-015021-pol2qm74	1576	3	for	for	IN
cord-015021-pol2qm74	1576	4	Fc'/RUCD64	Fc'/RUCD64	NNP
cord-015021-pol2qm74	1576	5	as	as	RB
cord-015021-pol2qm74	1576	6	well	well	RB
cord-015021-pol2qm74	1576	7	as	as	IN
cord-015021-pol2qm74	1576	8	the	the	DT
cord-015021-pol2qm74	1576	9	receptors	receptor	NNS
cord-015021-pol2qm74	1576	10	for	for	IN
cord-015021-pol2qm74	1576	11	complement	complement	JJ
cord-015021-pol2qm74	1576	12	CR3	CR3	NNP
cord-015021-pol2qm74	1576	13	/	/	SYM
cord-015021-pol2qm74	1576	14	CDllb	CDllb	NNP
cord-015021-pol2qm74	1576	15	and	and	CC
cord-015021-pol2qm74	1576	16	CR4	CR4	NNP
cord-015021-pol2qm74	1576	17	/	/	SYM
cord-015021-pol2qm74	1576	18	CDllc	CDllc	NNP
cord-015021-pol2qm74	1576	19	were	be	VBD
cord-015021-pol2qm74	1576	20	down	down	RB
cord-015021-pol2qm74	1576	21	-	-	HYPH
cord-015021-pol2qm74	1576	22	regulated	regulate	VBN
cord-015021-pol2qm74	1576	23	.	.	.
cord-015021-pol2qm74	1577	1	CR1	CR1	NNP
cord-015021-pol2qm74	1577	2	/	/	SYM
cord-015021-pol2qm74	1577	3	CD35	CD35	NNP
cord-015021-pol2qm74	1577	4	which	which	WDT
cord-015021-pol2qm74	1577	5	is	be	VBZ
cord-015021-pol2qm74	1577	6	only	only	RB
cord-015021-pol2qm74	1577	7	slightly	slightly	RB
cord-015021-pol2qm74	1577	8	expressed	express	VBN
cord-015021-pol2qm74	1577	9	on	on	IN
cord-015021-pol2qm74	1577	10	monocytes	monocyte	NNS
cord-015021-pol2qm74	1577	11	was	be	VBD
cord-015021-pol2qm74	1577	12	not	not	RB
cord-015021-pol2qm74	1577	13	influenced	influence	VBN
cord-015021-pol2qm74	1577	14	.	.	.
cord-015021-pol2qm74	1578	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	1578	2	,	,	,
cord-015021-pol2qm74	1578	3	no	no	DT
cord-015021-pol2qm74	1578	4	effects	effect	NNS
cord-015021-pol2qm74	1578	5	on	on	IN
cord-015021-pol2qm74	1578	6	the	the	DT
cord-015021-pol2qm74	1578	7	expression	expression	NN
cord-015021-pol2qm74	1578	8	of	of	IN
cord-015021-pol2qm74	1578	9	CDI4	CDI4	NNP
cord-015021-pol2qm74	1578	10	,	,	,
cord-015021-pol2qm74	1578	11	the	the	DT
cord-015021-pol2qm74	1578	12	receptor	receptor	NN
cord-015021-pol2qm74	1578	13	for	for	IN
cord-015021-pol2qm74	1578	14	transferrin	transferrin	NN
cord-015021-pol2qm74	1578	15	CD71	CD71	NNP
cord-015021-pol2qm74	1578	16	and	and	CC
cord-015021-pol2qm74	1578	17	Fc'fRIII	Fc'fRIII	NNP
cord-015021-pol2qm74	1578	18	/	/	SYM
cord-015021-pol2qm74	1578	19	CD16	CD16	NNP
cord-015021-pol2qm74	1578	20	were	be	VBD
cord-015021-pol2qm74	1578	21	seen	see	VBN
cord-015021-pol2qm74	1578	22	.	.	.
cord-015021-pol2qm74	1579	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	1579	2	data	datum	NNS
cord-015021-pol2qm74	1579	3	indicate	indicate	VBP
cord-015021-pol2qm74	1579	4	,	,	,
cord-015021-pol2qm74	1579	5	that	that	IN
cord-015021-pol2qm74	1579	6	lower	low	JJR
cord-015021-pol2qm74	1579	7	concentrations	concentration	NNS
cord-015021-pol2qm74	1579	8	of	of	IN
cord-015021-pol2qm74	1579	9	glutamme	glutamme	NN
cord-015021-pol2qm74	1579	10	influence	influence	VBP
cord-015021-pol2qm74	1579	11	the	the	DT
cord-015021-pol2qm74	1579	12	phenotype	phenotype	NN
cord-015021-pol2qm74	1579	13	of	of	IN
cord-015021-pol2qm74	1579	14	monocytes	monocyte	NNS
cord-015021-pol2qm74	1579	15	.	.	.
cord-015021-pol2qm74	1580	1	We	-PRON-	PRP
cord-015021-pol2qm74	1580	2	are	be	VBP
cord-015021-pol2qm74	1580	3	now	now	RB
cord-015021-pol2qm74	1580	4	interested	interested	JJ
cord-015021-pol2qm74	1580	5	to	to	TO
cord-015021-pol2qm74	1580	6	study	study	VB
cord-015021-pol2qm74	1580	7	whether	whether	IN
cord-015021-pol2qm74	1580	8	glutmnine	glutmnine	NNP
cord-015021-pol2qm74	1580	9	influences	influence	NNS
cord-015021-pol2qm74	1580	10	non	non	JJ
cord-015021-pol2qm74	1580	11	-	-	JJ
cord-015021-pol2qm74	1580	12	specific	specific	JJ
cord-015021-pol2qm74	1580	13	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	1580	14	,	,	,
cord-015021-pol2qm74	1580	15	or	or	CC
cord-015021-pol2qm74	1580	16	whether	whether	IN
cord-015021-pol2qm74	1580	17	specific	specific	JJ
cord-015021-pol2qm74	1580	18	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	1580	19	correlates	correlate	VBZ
cord-015021-pol2qm74	1580	20	with	with	IN
cord-015021-pol2qm74	1580	21	the	the	DT
cord-015021-pol2qm74	1580	22	decreased	decreased	JJ
cord-015021-pol2qm74	1580	23	expression	expression	NN
cord-015021-pol2qm74	1580	24	of	of	IN
cord-015021-pol2qm74	1580	25	Fc'/R	Fc'/R	NNS
cord-015021-pol2qm74	1580	26	and	and	CC
cord-015021-pol2qm74	1580	27	complement	complement	VB
cord-015021-pol2qm74	1580	28	receptors	receptor	NNS
cord-015021-pol2qm74	1580	29	.	.	.
cord-015021-pol2qm74	1581	1	We	-PRON-	PRP
cord-015021-pol2qm74	1581	2	investigated	investigate	VBD
cord-015021-pol2qm74	1581	3	immunologically	immunologically	RB
cord-015021-pol2qm74	1581	4	more	more	JJR
cord-015021-pol2qm74	1581	5	than	than	IN
cord-015021-pol2qm74	1581	6	300	300	CD
cord-015021-pol2qm74	1581	7	patients	patient	NNS
cord-015021-pol2qm74	1581	8	who	who	WP
cord-015021-pol2qm74	1581	9	were	be	VBD
cord-015021-pol2qm74	1581	10	admitted	admit	VBN
cord-015021-pol2qm74	1581	11	to	to	IN
cord-015021-pol2qm74	1581	12	ICU	ICU	NNP
cord-015021-pol2qm74	1581	13	because	because	IN
cord-015021-pol2qm74	1581	14	septic	septic	JJ
cord-015021-pol2qm74	1581	15	syndrom	syndrom	NN
cord-015021-pol2qm74	1581	16	during	during	IN
cord-015021-pol2qm74	1581	17	the	the	DT
cord-015021-pol2qm74	1581	18	last	last	JJ
cord-015021-pol2qm74	1581	19	four	four	CD
cord-015021-pol2qm74	1581	20	years	year	NNS
cord-015021-pol2qm74	1581	21	.	.	.
cord-015021-pol2qm74	1582	1	Patients	patient	NNS
cord-015021-pol2qm74	1582	2	were	be	VBD
cord-015021-pol2qm74	1582	3	immunologically	immunologically	RB
cord-015021-pol2qm74	1582	4	followed	follow	VBN
cord-015021-pol2qm74	1582	5	up	up	RP
cord-015021-pol2qm74	1582	6	2	2	CD
cord-015021-pol2qm74	1582	7	-	-	SYM
cord-015021-pol2qm74	1582	8	3	3	CD
cord-015021-pol2qm74	1582	9	times	time	NNS
cord-015021-pol2qm74	1582	10	per	per	IN
cord-015021-pol2qm74	1582	11	week	week	NN
cord-015021-pol2qm74	1582	12	until	until	IN
cord-015021-pol2qm74	1582	13	release	release	NN
cord-015021-pol2qm74	1582	14	from	from	IN
cord-015021-pol2qm74	1582	15	ICU	ICU	NNP
cord-015021-pol2qm74	1582	16	.	.	.
cord-015021-pol2qm74	1583	1	The	the	DT
cord-015021-pol2qm74	1583	2	expression	expression	NN
cord-015021-pol2qm74	1583	3	of	of	IN
cord-015021-pol2qm74	1583	4	HLA	HLA	NNP
cord-015021-pol2qm74	1583	5	-	-	HYPH
cord-015021-pol2qm74	1583	6	DR	DR	NNP
cord-015021-pol2qm74	1583	7	antigen	antigen	NN
cord-015021-pol2qm74	1583	8	on	on	IN
cord-015021-pol2qm74	1583	9	monocytes	monocyte	NNS
cord-015021-pol2qm74	1583	10	turned	turn	VBD
cord-015021-pol2qm74	1583	11	out	out	RP
cord-015021-pol2qm74	1583	12	to	to	TO
cord-015021-pol2qm74	1583	13	be	be	VB
cord-015021-pol2qm74	1583	14	the	the	DT
cord-015021-pol2qm74	1583	15	best	good	JJS
cord-015021-pol2qm74	1583	16	prognostic	prognostic	JJ
cord-015021-pol2qm74	1583	17	parameter	parameter	NN
cord-015021-pol2qm74	1583	18	.	.	.
cord-015021-pol2qm74	1584	1	The	the	DT
cord-015021-pol2qm74	1584	2	persistence	persistence	NN
cord-015021-pol2qm74	1584	3	(	(	-LRB-
cord-015021-pol2qm74	1584	4	>	>	NFP
cord-015021-pol2qm74	1584	5	5	5	CD
cord-015021-pol2qm74	1584	6	days	day	NNS
cord-015021-pol2qm74	1584	7	)	)	-RRB-
cord-015021-pol2qm74	1584	8	of	of	IN
cord-015021-pol2qm74	1584	9	low	low	JJ
cord-015021-pol2qm74	1584	10	HLA	HLA	NNP
cord-015021-pol2qm74	1584	11	-	-	HYPH
cord-015021-pol2qm74	1584	12	DR	DR	NNP
cord-015021-pol2qm74	1584	13	expression	expression	NN
cord-015021-pol2qm74	1584	14	(	(	-LRB-
cord-015021-pol2qm74	1584	15	<	<	NNP
cord-015021-pol2qm74	1584	16	30	30	CD
cord-015021-pol2qm74	1584	17	%	%	NN
cord-015021-pol2qm74	1584	18	)	)	-RRB-
cord-015021-pol2qm74	1584	19	predicts	predict	VBZ
cord-015021-pol2qm74	1584	20	fatal	fatal	JJ
cord-015021-pol2qm74	1584	21	outcome	outcome	NN
cord-015021-pol2qm74	1584	22	(	(	-LRB-
cord-015021-pol2qm74	1584	23	mortality	mortality	NN
cord-015021-pol2qm74	1584	24	>	>	XX
cord-015021-pol2qm74	1584	25	85	85	CD
cord-015021-pol2qm74	1584	26	%	%	NN
cord-015021-pol2qm74	1584	27	)	)	-RRB-
cord-015021-pol2qm74	1584	28	.	.	.
cord-015021-pol2qm74	1585	1	The	the	DT
cord-015021-pol2qm74	1585	2	altered	altered	JJ
cord-015021-pol2qm74	1585	3	phenotype	phenotype	NN
cord-015021-pol2qm74	1585	4	was	be	VBD
cord-015021-pol2qm74	1585	5	associated	associate	VBN
cord-015021-pol2qm74	1585	6	with	with	IN
cord-015021-pol2qm74	1585	7	a	a	DT
cord-015021-pol2qm74	1585	8	functional	functional	JJ
cord-015021-pol2qm74	1585	9	deactivation	deactivation	NN
cord-015021-pol2qm74	1585	10	of	of	IN
cord-015021-pol2qm74	1585	11	monocytes	monocyte	NNS
cord-015021-pol2qm74	1585	12	(	(	-LRB-
cord-015021-pol2qm74	1585	13	diminished	diminish	VBD
cord-015021-pol2qm74	1585	14	APC	APC	NNP
cord-015021-pol2qm74	1585	15	,	,	,
cord-015021-pol2qm74	1585	16	ROS	ROS	NNP
cord-015021-pol2qm74	1585	17	formation	formation	NN
cord-015021-pol2qm74	1585	18	,	,	,
cord-015021-pol2qm74	1585	19	cytokine	cytokine	JJ
cord-015021-pol2qm74	1585	20	secretion	secretion	NN
cord-015021-pol2qm74	1585	21	)	)	-RRB-
cord-015021-pol2qm74	1585	22	.	.	.
cord-015021-pol2qm74	1586	1	We	-PRON-	PRP
cord-015021-pol2qm74	1586	2	called	call	VBD
cord-015021-pol2qm74	1586	3	this	this	DT
cord-015021-pol2qm74	1586	4	phenomenon	phenomenon	NN
cord-015021-pol2qm74	1586	5	"	"	``
cord-015021-pol2qm74	1586	6	immunoparalysis	immunoparalysis	NN
cord-015021-pol2qm74	1586	7	"	"	''
cord-015021-pol2qm74	1586	8	.	.	.
cord-015021-pol2qm74	1587	1	IFN	IFN	NNP
cord-015021-pol2qm74	1587	2	-	-	HYPH
cord-015021-pol2qm74	1587	3	gamma	gamma	NN
cord-015021-pol2qm74	1587	4	and	and	CC
cord-015021-pol2qm74	1587	5	GM	GM	NNP
cord-015021-pol2qm74	1587	6	-	-	HYPH
cord-015021-pol2qm74	1587	7	CSF	CSF	NNP
cord-015021-pol2qm74	1587	8	were	be	VBD
cord-015021-pol2qm74	1587	9	able	able	JJ
cord-015021-pol2qm74	1587	10	to	to	TO
cord-015021-pol2qm74	1587	11	restore	restore	VB
cord-015021-pol2qm74	1587	12	the	the	DT
cord-015021-pol2qm74	1587	13	altered	altered	JJ
cord-015021-pol2qm74	1587	14	phenotype	phenotype	NN
cord-015021-pol2qm74	1587	15	and	and	CC
cord-015021-pol2qm74	1587	16	function	function	VB
cord-015021-pol2qm74	1587	17	in	in	IN
cord-015021-pol2qm74	1587	18	vitro	vitro	FW
cord-015021-pol2qm74	1587	19	.	.	.
cord-015021-pol2qm74	1588	1	However	however	RB
cord-015021-pol2qm74	1588	2	,	,	,
cord-015021-pol2qm74	1588	3	addition	addition	NN
cord-015021-pol2qm74	1588	4	of	of	IN
cord-015021-pol2qm74	1588	5	autologous	autologous	JJ
cord-015021-pol2qm74	1588	6	plasma	plasma	NN
cord-015021-pol2qm74	1588	7	from	from	IN
cord-015021-pol2qm74	1588	8	septic	septic	JJ
cord-015021-pol2qm74	1588	9	patients	patient	NNS
cord-015021-pol2qm74	1588	10	with	with	IN
cord-015021-pol2qm74	1588	11	"	"	``
cord-015021-pol2qm74	1588	12	immunoparalysis	immunoparalysis	NN
cord-015021-pol2qm74	1588	13	"	"	''
cord-015021-pol2qm74	1588	14	to	to	IN
cord-015021-pol2qm74	1588	15	these	these	DT
cord-015021-pol2qm74	1588	16	cultures	culture	NNS
cord-015021-pol2qm74	1588	17	prevented	prevent	VBD
cord-015021-pol2qm74	1588	18	the	the	DT
cord-015021-pol2qm74	1588	19	cytokine	cytokine	NN
cord-015021-pol2qm74	1588	20	-	-	HYPH
cord-015021-pol2qm74	1588	21	induced	induce	VBN
cord-015021-pol2qm74	1588	22	restitution	restitution	NN
cord-015021-pol2qm74	1588	23	.	.	.
cord-015021-pol2qm74	1589	1	The	the	DT
cord-015021-pol2qm74	1589	2	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1589	3	activity	activity	NN
cord-015021-pol2qm74	1589	4	could	could	MD
cord-015021-pol2qm74	1589	5	not	not	RB
cord-015021-pol2qm74	1589	6	be	be	VB
cord-015021-pol2qm74	1589	7	removed	remove	VBN
cord-015021-pol2qm74	1589	8	by	by	IN
cord-015021-pol2qm74	1589	9	dialysis	dialysis	NN
cord-015021-pol2qm74	1589	10	.	.	.
cord-015021-pol2qm74	1590	1	Therefore	therefore	RB
cord-015021-pol2qm74	1590	2	,	,	,
cord-015021-pol2qm74	1590	3	we	-PRON-	PRP
cord-015021-pol2qm74	1590	4	started	start	VBD
cord-015021-pol2qm74	1590	5	a	a	DT
cord-015021-pol2qm74	1590	6	study	study	NN
cord-015021-pol2qm74	1590	7	to	to	TO
cord-015021-pol2qm74	1590	8	prove	prove	VB
cord-015021-pol2qm74	1590	9	the	the	DT
cord-015021-pol2qm74	1590	10	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1590	11	efficacy	efficacy	NN
cord-015021-pol2qm74	1590	12	of	of	IN
cord-015021-pol2qm74	1590	13	plasmapheresis	plasmapheresis	NN
cord-015021-pol2qm74	1590	14	.	.	.
cord-015021-pol2qm74	1591	1	Indeed	indeed	RB
cord-015021-pol2qm74	1591	2	,	,	,
cord-015021-pol2qm74	1591	3	[	[	-LRB-
cord-015021-pol2qm74	1591	4	7	7	CD
cord-015021-pol2qm74	1591	5	of	of	IN
cord-015021-pol2qm74	1591	6	33	33	CD
cord-015021-pol2qm74	1591	7	patients	patient	NNS
cord-015021-pol2qm74	1591	8	recovered	recover	VBN
cord-015021-pol2qm74	1591	9	from	from	IN
cord-015021-pol2qm74	1591	10	"	"	``
cord-015021-pol2qm74	1591	11	immunoparalysis	immunoparalysis	NN
cord-015021-pol2qm74	1591	12	"	"	''
cord-015021-pol2qm74	1591	13	following	follow	VBG
cord-015021-pol2qm74	1591	14	repeated	repeat	VBN
cord-015021-pol2qm74	1591	15	plasmapheres	plasmaphere	NNS
cord-015021-pol2qm74	1591	16	;	;	:
cord-015021-pol2qm74	1591	17	16	16	CD
cord-015021-pol2qm74	1591	18	of	of	IN
cord-015021-pol2qm74	1591	19	them	-PRON-	PRP
cord-015021-pol2qm74	1591	20	survived	survive	VBD
cord-015021-pol2qm74	1591	21	(	(	-LRB-
cord-015021-pol2qm74	1591	22	46	46	CD
cord-015021-pol2qm74	1591	23	%	%	NN
cord-015021-pol2qm74	1591	24	)	)	-RRB-
cord-015021-pol2qm74	1591	25	.	.	.
cord-015021-pol2qm74	1592	1	7	7	CD
cord-015021-pol2qm74	1592	2	patients	patient	NNS
cord-015021-pol2qm74	1592	3	recovered	recover	VBD
cord-015021-pol2qm74	1592	4	temporarely	temporarely	RB
cord-015021-pol2qm74	1592	5	and	and	CC
cord-015021-pol2qm74	1592	6	9	9	CD
cord-015021-pol2qm74	1592	7	patients	patient	NNS
cord-015021-pol2qm74	1592	8	did	do	VBD
cord-015021-pol2qm74	1592	9	not	not	RB
cord-015021-pol2qm74	1592	10	respond	respond	VB
cord-015021-pol2qm74	1592	11	(	(	-LRB-
cord-015021-pol2qm74	1592	12	all	all	DT
cord-015021-pol2qm74	1592	13	16	16	CD
cord-015021-pol2qm74	1592	14	died	die	VBD
cord-015021-pol2qm74	1592	15	)	)	-RRB-
cord-015021-pol2qm74	1592	16	.	.	.
cord-015021-pol2qm74	1593	1	The	the	DT
cord-015021-pol2qm74	1593	2	survival	survival	NN
cord-015021-pol2qm74	1593	3	rate	rate	NN
cord-015021-pol2qm74	1593	4	in	in	IN
cord-015021-pol2qm74	1593	5	the	the	DT
cord-015021-pol2qm74	1593	6	control	control	NN
cord-015021-pol2qm74	1593	7	group	group	NN
cord-015021-pol2qm74	1593	8	of	of	IN
cord-015021-pol2qm74	1593	9	septic	septic	JJ
cord-015021-pol2qm74	1593	10	patients	patient	NNS
cord-015021-pol2qm74	1593	11	with	with	IN
cord-015021-pol2qm74	1593	12	persistent	persistent	JJ
cord-015021-pol2qm74	1593	13	"	"	``
cord-015021-pol2qm74	1593	14	immunoparalysis	immunoparalysis	NN
cord-015021-pol2qm74	1593	15	"	"	''
cord-015021-pol2qm74	1593	16	was	be	VBD
cord-015021-pol2qm74	1593	17	4	4	CD
cord-015021-pol2qm74	1593	18	of	of	IN
cord-015021-pol2qm74	1593	19	38	38	CD
cord-015021-pol2qm74	1593	20	(	(	-LRB-
cord-015021-pol2qm74	1593	21	11	11	CD
cord-015021-pol2qm74	1593	22	%	%	NN
cord-015021-pol2qm74	1593	23	;	;	,
cord-015021-pol2qm74	1593	24	p<0,01	p<0,01	NN
cord-015021-pol2qm74	1593	25	)	)	-RRB-
cord-015021-pol2qm74	1593	26	.	.	.
cord-015021-pol2qm74	1594	1	In	in	IN
cord-015021-pol2qm74	1594	2	summary	summary	NN
cord-015021-pol2qm74	1594	3	,	,	,
cord-015021-pol2qm74	1594	4	plasmapheresis	plasmapheresis	NN
cord-015021-pol2qm74	1594	5	in	in	IN
cord-015021-pol2qm74	1594	6	association	association	NN
cord-015021-pol2qm74	1594	7	with	with	IN
cord-015021-pol2qm74	1594	8	immune	immune	JJ
cord-015021-pol2qm74	1594	9	monitoring	monitoring	NN
cord-015021-pol2qm74	1594	10	may	may	MD
cord-015021-pol2qm74	1594	11	be	be	VB
cord-015021-pol2qm74	1594	12	an	an	DT
cord-015021-pol2qm74	1594	13	alternative	alternative	JJ
cord-015021-pol2qm74	1594	14	strategy	strategy	NN
cord-015021-pol2qm74	1594	15	to	to	TO
cord-015021-pol2qm74	1594	16	improve	improve	VB
cord-015021-pol2qm74	1594	17	survival	survival	NN
cord-015021-pol2qm74	1594	18	rate	rate	NN
cord-015021-pol2qm74	1594	19	in	in	IN
cord-015021-pol2qm74	1594	20	severe	severe	JJ
cord-015021-pol2qm74	1594	21	sepsis	sepsis	NN
cord-015021-pol2qm74	1594	22	.	.	.
cord-015021-pol2qm74	1595	1	Taurolidine	Taurolidine	NNP
cord-015021-pol2qm74	1595	2	,	,	,
cord-015021-pol2qm74	1595	3	a	a	DT
cord-015021-pol2qm74	1595	4	synthetic	synthetic	JJ
cord-015021-pol2qm74	1595	5	taurine	taurine	NN
cord-015021-pol2qm74	1595	6	-	-	HYPH
cord-015021-pol2qm74	1595	7	formaldehyde	formaldehyde	NN
cord-015021-pol2qm74	1595	8	derivative	derivative	NN
cord-015021-pol2qm74	1595	9	has	have	VBZ
cord-015021-pol2qm74	1595	10	antiadherent	antiadherent	NN
cord-015021-pol2qm74	1595	11	,	,	,
cord-015021-pol2qm74	1595	12	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	1595	13	and	and	CC
cord-015021-pol2qm74	1595	14	anti	anti	JJ
cord-015021-pol2qm74	1595	15	-	-	JJ
cord-015021-pol2qm74	1595	16	LPS	lps	JJ
cord-015021-pol2qm74	1595	17	properties	property	NNS
cord-015021-pol2qm74	1595	18	functioning	function	VBG
cord-015021-pol2qm74	1595	19	primarily	primarily	RB
cord-015021-pol2qm74	1595	20	through	through	IN
cord-015021-pol2qm74	1595	21	binding	binding	NN
cord-015021-pol2qm74	1595	22	of	of	IN
cord-015021-pol2qm74	1595	23	the	the	DT
cord-015021-pol2qm74	1595	24	lipid	lipid	NN
cord-015021-pol2qm74	1595	25	A	a	DT
cord-015021-pol2qm74	1595	26	region	region	NN
cord-015021-pol2qm74	1595	27	of	of	IN
cord-015021-pol2qm74	1595	28	the	the	DT
cord-015021-pol2qm74	1595	29	LPS	LPS	NNP
cord-015021-pol2qm74	1595	30	molecule	molecule	NN
cord-015021-pol2qm74	1595	31	.	.	.
cord-015021-pol2qm74	1596	1	The	the	DT
cord-015021-pol2qm74	1596	2	active	active	JJ
cord-015021-pol2qm74	1596	3	derivative	derivative	NN
cord-015021-pol2qm74	1596	4	of	of	IN
cord-015021-pol2qm74	1596	5	Taurolidine	Taurolidine	NNP
cord-015021-pol2qm74	1596	6	,	,	,
cord-015021-pol2qm74	1596	7	taurine	taurine	NN
cord-015021-pol2qm74	1596	8	,	,	,
cord-015021-pol2qm74	1596	9	modulates	modulate	VBZ
cord-015021-pol2qm74	1596	10	calcium	calcium	NN
cord-015021-pol2qm74	1596	11	channel	channel	NN
cord-015021-pol2qm74	1596	12	activity	activity	NN
cord-015021-pol2qm74	1596	13	,	,	,
cord-015021-pol2qm74	1596	14	critical	critical	JJ
cord-015021-pol2qm74	1596	15	to	to	IN
cord-015021-pol2qm74	1596	16	the	the	DT
cord-015021-pol2qm74	1596	17	initiation	initiation	NN
cord-015021-pol2qm74	1596	18	of	of	IN
cord-015021-pol2qm74	1596	19	a	a	DT
cord-015021-pol2qm74	1596	20	number	number	NN
cord-015021-pol2qm74	1596	21	of	of	IN
cord-015021-pol2qm74	1596	22	immunostimulatory	immunostimulatory	NNP
cord-015021-pol2qm74	1596	23	pathways	pathway	NNS
cord-015021-pol2qm74	1596	24	.	.	.
cord-015021-pol2qm74	1597	1	We	-PRON-	PRP
cord-015021-pol2qm74	1597	2	hypothesised	hypothesise	VBD
cord-015021-pol2qm74	1597	3	that	that	IN
cord-015021-pol2qm74	1597	4	Taurolidine	Taurolidine	NNP
cord-015021-pol2qm74	1597	5	may	may	MD
cord-015021-pol2qm74	1597	6	have	have	VB
cord-015021-pol2qm74	1597	7	direct	direct	JJ
cord-015021-pol2qm74	1597	8	immunostimulatory	immunostimulatory	NN
cord-015021-pol2qm74	1597	9	activity	activity	NN
cord-015021-pol2qm74	1597	10	.	.	.
cord-015021-pol2qm74	1598	1	The	the	DT
cord-015021-pol2qm74	1598	2	aim	aim	NN
cord-015021-pol2qm74	1598	3	of	of	IN
cord-015021-pol2qm74	1598	4	this	this	DT
cord-015021-pol2qm74	1598	5	study	study	NN
cord-015021-pol2qm74	1598	6	was	be	VBD
cord-015021-pol2qm74	1598	7	to	to	TO
cord-015021-pol2qm74	1598	8	investigate	investigate	VB
cord-015021-pol2qm74	1598	9	the	the	DT
cord-015021-pol2qm74	1598	10	immune	immune	JJ
cord-015021-pol2qm74	1598	11	effects	effect	NNS
cord-015021-pol2qm74	1598	12	of	of	IN
cord-015021-pol2qm74	1598	13	Taurolidine	Taurolidine	NNP
cord-015021-pol2qm74	1598	14	on	on	IN
cord-015021-pol2qm74	1598	15	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	1598	16	macrophage	macrophage	NN
cord-015021-pol2qm74	1598	17	(	(	-LRB-
cord-015021-pol2qm74	1598	18	PMO	PMO	NNP
cord-015021-pol2qm74	1598	19	)	)	-RRB-
cord-015021-pol2qm74	1598	20	function	function	NN
cord-015021-pol2qm74	1598	21	and	and	CC
cord-015021-pol2qm74	1598	22	then	then	RB
cord-015021-pol2qm74	1598	23	determine	determine	VB
cord-015021-pol2qm74	1598	24	the	the	DT
cord-015021-pol2qm74	1598	25	role	role	NN
cord-015021-pol2qm74	1598	26	of	of	IN
cord-015021-pol2qm74	1598	27	taurine	taurine	NN
cord-015021-pol2qm74	1598	28	in	in	IN
cord-015021-pol2qm74	1598	29	this	this	DT
cord-015021-pol2qm74	1598	30	response	response	NN
cord-015021-pol2qm74	1598	31	.	.	.
cord-015021-pol2qm74	1599	1	Study	study	NN
cord-015021-pol2qm74	1599	2	1	1	CD
cord-015021-pol2qm74	1599	3	:	:	:
cord-015021-pol2qm74	1600	1	In	in	IN
cord-015021-pol2qm74	1600	2	vivo	vivo	NN
cord-015021-pol2qm74	1600	3	stimulation	stimulation	NN
cord-015021-pol2qm74	1600	4	:	:	:
cord-015021-pol2qm74	1600	5	CD-1	CD-1	NNP
cord-015021-pol2qm74	1600	6	mice	mouse	NNS
cord-015021-pol2qm74	1600	7	(	(	-LRB-
cord-015021-pol2qm74	1600	8	n=35	n=35	NN
cord-015021-pol2qm74	1600	9	)	)	-RRB-
cord-015021-pol2qm74	1600	10	were	be	VBD
cord-015021-pol2qm74	1600	11	randomized	randomize	VBN
cord-015021-pol2qm74	1600	12	to	to	TO
cord-015021-pol2qm74	1600	13	receive	receive	VB
cord-015021-pol2qm74	1600	14	Taurolidine	Taurolidine	NNP
cord-015021-pol2qm74	1600	15	(	(	-LRB-
cord-015021-pol2qm74	1600	16	200mg	200mg	NNP
cord-015021-pol2qm74	1600	17	/	/	SYM
cord-015021-pol2qm74	1600	18	kg	kg	NNP
cord-015021-pol2qm74	1600	19	BW	BW	NNP
cord-015021-pol2qm74	1600	20	/	/	SYM
cord-015021-pol2qm74	1600	21	i.p	i.p	NNP
cord-015021-pol2qm74	1600	22	.	.	NNP
cord-015021-pol2qm74	1600	23	)	)	-RRB-
cord-015021-pol2qm74	1600	24	or	or	CC
cord-015021-pol2qm74	1600	25	saline	saline	NN
cord-015021-pol2qm74	1600	26	cor	cor	NNP
cord-015021-pol2qm74	1600	27	~	~	NNP
cord-015021-pol2qm74	1600	28	trol	trol	NNP
cord-015021-pol2qm74	1600	29	.	.	.
cord-015021-pol2qm74	1601	1	PeritoneaI	peritoneai	JJ
cord-015021-pol2qm74	1601	2	cells	cell	NNS
cord-015021-pol2qm74	1601	3	were	be	VBD
cord-015021-pol2qm74	1601	4	harvested	harvest	VBN
cord-015021-pol2qm74	1601	5	after	after	IN
cord-015021-pol2qm74	1601	6	24	24	CD
cord-015021-pol2qm74	1601	7	hours	hour	NNS
cord-015021-pol2qm74	1601	8	and	and	CC
cord-015021-pol2qm74	1601	9	were	be	VBD
cord-015021-pol2qm74	1601	10	assessed	assess	VBN
cord-015021-pol2qm74	1601	11	for	for	IN
cord-015021-pol2qm74	1601	12	PM0	pm0	NN
cord-015021-pol2qm74	1601	13	function	function	NN
cord-015021-pol2qm74	1601	14	[	[	-LRB-
cord-015021-pol2qm74	1601	15	Superoxide	superoxide	NN
cord-015021-pol2qm74	1601	16	anion	anion	NN
cord-015021-pol2qm74	1601	17	generation	generation	NN
cord-015021-pol2qm74	1601	18	(	(	-LRB-
cord-015021-pol2qm74	1601	19	O2-	o2-	UH
cord-015021-pol2qm74	1601	20	)	)	-RRB-
cord-015021-pol2qm74	1601	21	,	,	,
cord-015021-pol2qm74	1601	22	Nitric	nitric	NN
cord-015021-pol2qm74	1601	23	oxide	oxide	NN
cord-015021-pol2qm74	1601	24	(	(	-LRB-
cord-015021-pol2qm74	1601	25	NO	no	RB
cord-015021-pol2qm74	1601	26	)	)	-RRB-
cord-015021-pol2qm74	1601	27	,	,	,
cord-015021-pol2qm74	1601	28	Tumor	tumor	NN
cord-015021-pol2qm74	1601	29	necrosis	necrosis	NN
cord-015021-pol2qm74	1601	30	factor	factor	NN
cord-015021-pol2qm74	1601	31	(	(	-LRB-
cord-015021-pol2qm74	1601	32	TNF	TNF	NNP
cord-015021-pol2qm74	1601	33	)	)	-RRB-
cord-015021-pol2qm74	1601	34	,	,	,
cord-015021-pol2qm74	1601	35	Fc	Fc	NNP
cord-015021-pol2qm74	1601	36	/	/	SYM
cord-015021-pol2qm74	1601	37	CR3-mediated	cr3-mediate	VBN
cord-015021-pol2qm74	1601	38	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	1601	39	function	function	NN
cord-015021-pol2qm74	1601	40	(	(	-LRB-
cord-015021-pol2qm74	1601	41	Phago	Phago	NNP
cord-015021-pol2qm74	1601	42	)	)	-RRB-
cord-015021-pol2qm74	1601	43	Study	Study	NNP
cord-015021-pol2qm74	1601	44	2	2	CD
cord-015021-pol2qm74	1601	45	:	:	:
cord-015021-pol2qm74	1602	1	Control	Control	NNP
cord-015021-pol2qm74	1602	2	PM0	PM0	NNP
cord-015021-pol2qm74	1602	3	were	be	VBD
cord-015021-pol2qm74	1602	4	harvested	harvest	VBN
cord-015021-pol2qm74	1602	5	and	and	CC
cord-015021-pol2qm74	1602	6	cultured	culture	VBN
cord-015021-pol2qm74	1602	7	in	in	IN
cord-015021-pol2qm74	1602	8	vitro	vitro	FW
cord-015021-pol2qm74	1602	9	with	with	IN
cord-015021-pol2qm74	1602	10	taurine	taurine	NN
cord-015021-pol2qm74	1602	11	(	(	-LRB-
cord-015021-pol2qm74	1602	12	1.0mg	1.0mg	CD
cord-015021-pol2qm74	1602	13	/	/	SYM
cord-015021-pol2qm74	1602	14	ml	ml	NN
cord-015021-pol2qm74	1602	15	for	for	IN
cord-015021-pol2qm74	1602	16	10	10	CD
cord-015021-pol2qm74	1602	17	hrs	hrs	NN
cord-015021-pol2qm74	1602	18	)	)	-RRB-
cord-015021-pol2qm74	1602	19	,	,	,
cord-015021-pol2qm74	1602	20	after	after	IN
cord-015021-pol2qm74	1602	21	which	which	WDT
cord-015021-pol2qm74	1602	22	time	time	NN
cord-015021-pol2qm74	1602	23	they	-PRON-	PRP
cord-015021-pol2qm74	1602	24	were	be	VBD
cord-015021-pol2qm74	1602	25	assayed	assay	VBN
cord-015021-pol2qm74	1602	26	for	for	IN
cord-015021-pol2qm74	1602	27	0	0	CD
cord-015021-pol2qm74	1602	28	2-and	2-and	CD
cord-015021-pol2qm74	1602	29	TNF	TNF	NNP
cord-015021-pol2qm74	1602	30	release	release	NN
cord-015021-pol2qm74	1602	31	.	.	.
cord-015021-pol2qm74	1603	1	In	in	IN
cord-015021-pol2qm74	1603	2	vivo	vivo	NN
cord-015021-pol2qm74	1603	3	stimulation	stimulation	NN
cord-015021-pol2qm74	1603	4	with	with	IN
cord-015021-pol2qm74	1603	5	Taurolidine	Taurolidine	NNP
cord-015021-pol2qm74	1603	6	Taurolidine	Taurolidine	NNP
cord-015021-pol2qm74	1603	7	has	have	VBZ
cord-015021-pol2qm74	1603	8	specific	specific	JJ
cord-015021-pol2qm74	1603	9	immunological	immunological	JJ
cord-015021-pol2qm74	1603	10	effects	effect	NNS
cord-015021-pol2qm74	1603	11	on	on	IN
cord-015021-pol2qm74	1603	12	M0	m0	NN
cord-015021-pol2qm74	1603	13	.	.	.
cord-015021-pol2qm74	1604	1	Release	release	NN
cord-015021-pol2qm74	1604	2	of	of	IN
cord-015021-pol2qm74	1604	3	the	the	DT
cord-015021-pol2qm74	1604	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1604	5	mediators	mediator	NNS
cord-015021-pol2qm74	1604	6	0	0	CD
cord-015021-pol2qm74	1604	7	2-and	2-and	CD
cord-015021-pol2qm74	1604	8	TNF	TNF	NNP
cord-015021-pol2qm74	1604	9	,	,	,
cord-015021-pol2qm74	1604	10	and	and	CC
cord-015021-pol2qm74	1604	11	Fc	Fc	NNP
cord-015021-pol2qm74	1604	12	/	/	SYM
cord-015021-pol2qm74	1604	13	CR3-mediated	cr3-mediate	VBN
cord-015021-pol2qm74	1604	14	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	1604	15	were	be	VBD
cord-015021-pol2qm74	1604	16	significantly	significantly	RB
cord-015021-pol2qm74	1604	17	increased	increase	VBN
cord-015021-pol2qm74	1604	18	,	,	,
cord-015021-pol2qm74	1604	19	while	while	IN
cord-015021-pol2qm74	1604	20	release	release	NN
cord-015021-pol2qm74	1604	21	of	of	IN
cord-015021-pol2qm74	1604	22	the	the	DT
cord-015021-pol2qm74	1604	23	endothelial	endothelial	JJ
cord-015021-pol2qm74	1604	24	relaxing	relaxing	JJ
cord-015021-pol2qm74	1604	25	factor	factor	NN
cord-015021-pol2qm74	1604	26	NO	no	UH
cord-015021-pol2qm74	1604	27	was	be	VBD
cord-015021-pol2qm74	1604	28	significantly	significantly	RB
cord-015021-pol2qm74	1604	29	reduced	reduce	VBN
cord-015021-pol2qm74	1604	30	.	.	.
cord-015021-pol2qm74	1605	1	In	in	IN
cord-015021-pol2qm74	1605	2	addition	addition	NN
cord-015021-pol2qm74	1605	3	,	,	,
cord-015021-pol2qm74	1605	4	the	the	DT
cord-015021-pol2qm74	1605	5	amino	amino	NN
cord-015021-pol2qm74	1605	6	acid	acid	NN
cord-015021-pol2qm74	1605	7	taurine	taurine	NN
cord-015021-pol2qm74	1605	8	,	,	,
cord-015021-pol2qm74	1605	9	which	which	WDT
cord-015021-pol2qm74	1605	10	is	be	VBZ
cord-015021-pol2qm74	1605	11	released	release	VBN
cord-015021-pol2qm74	1605	12	as	as	IN
cord-015021-pol2qm74	1605	13	a	a	DT
cord-015021-pol2qm74	1605	14	byproduct	byproduct	NN
cord-015021-pol2qm74	1605	15	of	of	IN
cord-015021-pol2qm74	1605	16	Taurolidines	Taurolidines	NNPS
cord-015021-pol2qm74	1605	17	breakdown	breakdown	NN
cord-015021-pol2qm74	1605	18	has	have	VBZ
cord-015021-pol2qm74	1605	19	an	an	DT
cord-015021-pol2qm74	1605	20	immunostimulatory	immunostimulatory	JJ
cord-015021-pol2qm74	1605	21	effect	effect	NN
cord-015021-pol2qm74	1605	22	on	on	IN
cord-015021-pol2qm74	1605	23	PMO	PMO	NNP
cord-015021-pol2qm74	1605	24	and	and	CC
cord-015021-pol2qm74	1605	25	may	may	MD
cord-015021-pol2qm74	1605	26	be	be	VB
cord-015021-pol2qm74	1605	27	the	the	DT
cord-015021-pol2qm74	1605	28	active	active	JJ
cord-015021-pol2qm74	1605	29	moeity	moeity	NN
cord-015021-pol2qm74	1605	30	of	of	IN
cord-015021-pol2qm74	1605	31	the	the	DT
cord-015021-pol2qm74	1605	32	compound	compound	NN
cord-015021-pol2qm74	1605	33	Tanrolidine	Tanrolidine	NNP
cord-015021-pol2qm74	1605	34	.	.	.
cord-015021-pol2qm74	1606	1	In	in	IN
cord-015021-pol2qm74	1606	2	sepsis	sepsis	NN
cord-015021-pol2qm74	1606	3	,	,	,
cord-015021-pol2qm74	1606	4	a	a	DT
cord-015021-pol2qm74	1606	5	number	number	NN
cord-015021-pol2qm74	1606	6	of	of	IN
cord-015021-pol2qm74	1606	7	mediators	mediator	NNS
cord-015021-pol2qm74	1606	8	which	which	WDT
cord-015021-pol2qm74	1606	9	affect	affect	VBP
cord-015021-pol2qm74	1606	10	vasomotor	vasomotor	NN
cord-015021-pol2qm74	1606	11	tone	tone	NN
cord-015021-pol2qm74	1606	12	and	and	CC
cord-015021-pol2qm74	1606	13	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	1606	14	function	function	NN
cord-015021-pol2qm74	1606	15	are	be	VBP
cord-015021-pol2qm74	1606	16	produced	produce	VBN
cord-015021-pol2qm74	1606	17	.	.	.
cord-015021-pol2qm74	1607	1	Inasmuch	inasmuch	IN
cord-015021-pol2qm74	1607	2	as	as	IN
cord-015021-pol2qm74	1607	3	sepsis	sepsis	NN
cord-015021-pol2qm74	1607	4	causes	cause	VBZ
cord-015021-pol2qm74	1607	5	decrease	decrease	NN
cord-015021-pol2qm74	1607	6	in	in	IN
cord-015021-pol2qm74	1607	7	systemic	systemic	JJ
cord-015021-pol2qm74	1607	8	vascular	vascular	JJ
cord-015021-pol2qm74	1607	9	resistance	resistance	NN
cord-015021-pol2qm74	1607	10	(	(	-LRB-
cord-015021-pol2qm74	1607	11	SVR	SVR	NNP
cord-015021-pol2qm74	1607	12	)	)	-RRB-
cord-015021-pol2qm74	1607	13	,	,	,
cord-015021-pol2qm74	1607	14	attention	attention	NN
cord-015021-pol2qm74	1607	15	is	be	VBZ
cord-015021-pol2qm74	1607	16	usually	usually	RB
cord-015021-pol2qm74	1607	17	focussed	focusse	VBN
cord-015021-pol2qm74	1607	18	on	on	IN
cord-015021-pol2qm74	1607	19	vasodilators	vasodilator	NNS
cord-015021-pol2qm74	1607	20	such	such	JJ
cord-015021-pol2qm74	1607	21	as	as	IN
cord-015021-pol2qm74	1607	22	lactate	lactate	NN
cord-015021-pol2qm74	1607	23	,	,	,
cord-015021-pol2qm74	1607	24	tumor	tumor	NN
cord-015021-pol2qm74	1607	25	necrosis	necrosis	NN
cord-015021-pol2qm74	1607	26	factor	factor	NN
cord-015021-pol2qm74	1607	27	,	,	,
cord-015021-pol2qm74	1607	28	interleukin	interleukin	NN
cord-015021-pol2qm74	1607	29	-	-	:
cord-015021-pol2qm74	1607	30	i	i	PRP
cord-015021-pol2qm74	1607	31	&	&	CC
cord-015021-pol2qm74	1607	32	2	2	CD
cord-015021-pol2qm74	1607	33	,	,	,
cord-015021-pol2qm74	1607	34	and	and	CC
cord-015021-pol2qm74	1607	35	nitric	nitric	NN
cord-015021-pol2qm74	1607	36	oxide	oxide	NN
cord-015021-pol2qm74	1607	37	.	.	.
cord-015021-pol2qm74	1608	1	But	but	CC
cord-015021-pol2qm74	1608	2	injury	injury	NN
cord-015021-pol2qm74	1608	3	and	and	CC
cord-015021-pol2qm74	1608	4	inflammation	inflammation	NN
cord-015021-pol2qm74	1608	5	als0	als0	TO
cord-015021-pol2qm74	1608	6	cause	cause	VBP
cord-015021-pol2qm74	1608	7	production	production	NN
cord-015021-pol2qm74	1608	8	of	of	IN
cord-015021-pol2qm74	1608	9	several	several	JJ
cord-015021-pol2qm74	1608	10	vasoconstrictors	vasoconstrictor	NNS
cord-015021-pol2qm74	1608	11	whose	whose	WP$
cord-015021-pol2qm74	1608	12	effect	effect	NN
cord-015021-pol2qm74	1608	13	may	may	MD
cord-015021-pol2qm74	1608	14	not	not	RB
cord-015021-pol2qm74	1608	15	be	be	VB
cord-015021-pol2qm74	1608	16	evident	evident	JJ
cord-015021-pol2qm74	1608	17	in	in	IN
cord-015021-pol2qm74	1608	18	changed	change	VBN
cord-015021-pol2qm74	1608	19	SVR	SVR	NNP
cord-015021-pol2qm74	1608	20	,	,	,
cord-015021-pol2qm74	1608	21	but	but	CC
cord-015021-pol2qm74	1608	22	may	may	MD
cord-015021-pol2qm74	1608	23	significantly	significantly	RB
cord-015021-pol2qm74	1608	24	affect	affect	VB
cord-015021-pol2qm74	1608	25	organ	organ	NN
cord-015021-pol2qm74	1608	26	blood	blood	NN
cord-015021-pol2qm74	1608	27	flow	flow	NN
cord-015021-pol2qm74	1608	28	or	or	CC
cord-015021-pol2qm74	1608	29	function	function	VB
cord-015021-pol2qm74	1608	30	in	in	IN
cord-015021-pol2qm74	1608	31	the	the	DT
cord-015021-pol2qm74	1608	32	paracrine	paracrine	JJ
cord-015021-pol2qm74	1608	33	environment	environment	NN
cord-015021-pol2qm74	1608	34	.	.	.
cord-015021-pol2qm74	1609	1	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	1609	2	(	(	-LRB-
cord-015021-pol2qm74	1609	3	ET	ET	NNP
cord-015021-pol2qm74	1609	4	)	)	-RRB-
cord-015021-pol2qm74	1609	5	is	be	VBZ
cord-015021-pol2qm74	1609	6	a	a	DT
cord-015021-pol2qm74	1609	7	21	21	CD
cord-015021-pol2qm74	1609	8	amino	amino	NN
cord-015021-pol2qm74	1609	9	acid	acid	NN
cord-015021-pol2qm74	1609	10	peptide	peptide	NN
cord-015021-pol2qm74	1609	11	vasoconstrictor	vasoconstrictor	NN
cord-015021-pol2qm74	1609	12	produced	produce	VBN
cord-015021-pol2qm74	1609	13	by	by	IN
cord-015021-pol2qm74	1609	14	ischemic	ischemic	JJ
cord-015021-pol2qm74	1609	15	or	or	CC
cord-015021-pol2qm74	1609	16	injured	injured	JJ
cord-015021-pol2qm74	1609	17	endothelial	endothelial	JJ
cord-015021-pol2qm74	1609	18	cells	cell	NNS
cord-015021-pol2qm74	1609	19	(	(	-LRB-
cord-015021-pol2qm74	1609	20	EC	EC	NNP
cord-015021-pol2qm74	1609	21	's	's	POS
cord-015021-pol2qm74	1609	22	)	)	-RRB-
cord-015021-pol2qm74	1609	23	.	.	.
cord-015021-pol2qm74	1610	1	ET	ET	NNP
cord-015021-pol2qm74	1610	2	is	be	VBZ
cord-015021-pol2qm74	1610	3	also	also	RB
cord-015021-pol2qm74	1610	4	a	a	DT
cord-015021-pol2qm74	1610	5	potent	potent	JJ
cord-015021-pol2qm74	1610	6	constrictor	constrictor	NN
cord-015021-pol2qm74	1610	7	for	for	IN
cord-015021-pol2qm74	1610	8	renal	renal	JJ
cord-015021-pol2qm74	1610	9	mesangial	mesangial	JJ
cord-015021-pol2qm74	1610	10	and	and	CC
cord-015021-pol2qm74	1610	11	coronary	coronary	JJ
cord-015021-pol2qm74	1610	12	vessels	vessel	NNS
cord-015021-pol2qm74	1610	13	,	,	,
cord-015021-pol2qm74	1610	14	an	an	DT
cord-015021-pol2qm74	1610	15	endocrine	endocrine	JJ
cord-015021-pol2qm74	1610	16	regulator	regulator	NN
cord-015021-pol2qm74	1610	17	,	,	,
cord-015021-pol2qm74	1610	18	and	and	CC
cord-015021-pol2qm74	1610	19	a	a	DT
cord-015021-pol2qm74	1610	20	negative	negative	JJ
cord-015021-pol2qm74	1610	21	cardiac	cardiac	JJ
cord-015021-pol2qm74	1610	22	inotrope	inotrope	NN
cord-015021-pol2qm74	1610	23	.	.	.
cord-015021-pol2qm74	1611	1	Systemic	systemic	JJ
cord-015021-pol2qm74	1611	2	ET	ET	NNP
cord-015021-pol2qm74	1611	3	levels	level	NNS
cord-015021-pol2qm74	1611	4	increase	increase	VBP
cord-015021-pol2qm74	1611	5	significantly	significantly	RB
cord-015021-pol2qm74	1611	6	in	in	IN
cord-015021-pol2qm74	1611	7	hypoperfusion	hypoperfusion	NN
cord-015021-pol2qm74	1611	8	and	and	CC
cord-015021-pol2qm74	1611	9	ischemia	ischemia	NN
cord-015021-pol2qm74	1611	10	.	.	.
cord-015021-pol2qm74	1612	1	While	while	IN
cord-015021-pol2qm74	1612	2	ET	ET	NNP
cord-015021-pol2qm74	1612	3	is	be	VBZ
cord-015021-pol2qm74	1612	4	principally	principally	RB
cord-015021-pol2qm74	1612	5	produced	produce	VBN
cord-015021-pol2qm74	1612	6	by	by	IN
cord-015021-pol2qm74	1612	7	EC	EC	NNP
cord-015021-pol2qm74	1612	8	's	's	POS
cord-015021-pol2qm74	1612	9	,	,	,
cord-015021-pol2qm74	1612	10	we	-PRON-	PRP
cord-015021-pol2qm74	1612	11	asked	ask	VBD
cord-015021-pol2qm74	1612	12	if	if	IN
cord-015021-pol2qm74	1612	13	human	human	JJ
cord-015021-pol2qm74	1612	14	monocytes	monocyte	NNS
cord-015021-pol2qm74	1612	15	might	may	MD
cord-015021-pol2qm74	1612	16	also	also	RB
cord-015021-pol2qm74	1612	17	produce	produce	VB
cord-015021-pol2qm74	1612	18	ET	ET	NNP
cord-015021-pol2qm74	1612	19	and	and	CC
cord-015021-pol2qm74	1612	20	thereby	thereby	RB
cord-015021-pol2qm74	1612	21	regulate	regulate	VB
cord-015021-pol2qm74	1612	22	vasomotor	vasomotor	NN
cord-015021-pol2qm74	1612	23	tone	tone	NN
cord-015021-pol2qm74	1612	24	in	in	IN
cord-015021-pol2qm74	1612	25	areas	area	NNS
cord-015021-pol2qm74	1612	26	of	of	IN
cord-015021-pol2qm74	1612	27	inflammation	inflammation	NN
cord-015021-pol2qm74	1612	28	.	.	.
cord-015021-pol2qm74	1613	1	Monocytes	monocyte	NNS
cord-015021-pol2qm74	1613	2	from	from	IN
cord-015021-pol2qm74	1613	3	healthy	healthy	JJ
cord-015021-pol2qm74	1613	4	donors	donor	NNS
cord-015021-pol2qm74	1613	5	were	be	VBD
cord-015021-pol2qm74	1613	6	separated	separate	VBN
cord-015021-pol2qm74	1613	7	on	on	IN
cord-015021-pol2qm74	1613	8	Ficoll	Ficoll	NNP
cord-015021-pol2qm74	1613	9	,	,	,
cord-015021-pol2qm74	1613	10	resuspended	resuspend	VBD
cord-015021-pol2qm74	1613	11	in	in	IN
cord-015021-pol2qm74	1613	12	RPMI	RPMI	NNP
cord-015021-pol2qm74	1613	13	1640	1640	CD
cord-015021-pol2qm74	1613	14	+5	+5	CD
cord-015021-pol2qm74	1613	15	%	%	NN
cord-015021-pol2qm74	1613	16	fetal	fetal	JJ
cord-015021-pol2qm74	1613	17	calf	calf	NN
cord-015021-pol2qm74	1613	18	serum	serum	NN
cord-015021-pol2qm74	1613	19	and	and	CC
cord-015021-pol2qm74	1613	20	stimulated	stimulate	VBD
cord-015021-pol2qm74	1613	21	with	with	IN
cord-015021-pol2qm74	1613	22	i0	i0	NNP
cord-015021-pol2qm74	1613	23	ug	ug	NNP
cord-015021-pol2qm74	1613	24	/	/	SYM
cord-015021-pol2qm74	1613	25	ml	ml	NN
cord-015021-pol2qm74	1613	26	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1613	27	(	(	-LRB-
cord-015021-pol2qm74	1613	28	LPS	LPS	NNP
cord-015021-pol2qm74	1613	29	)	)	-RRB-
cord-015021-pol2qm74	1613	30	.	.	.
cord-015021-pol2qm74	1614	1	ET	ET	NNP
cord-015021-pol2qm74	1614	2	was	be	VBD
cord-015021-pol2qm74	1614	3	measured	measure	VBN
cord-015021-pol2qm74	1614	4	by	by	IN
cord-015021-pol2qm74	1614	5	radioimmunoassay	radioimmunoassay	JJ
cord-015021-pol2qm74	1614	6	.	.	.
cord-015021-pol2qm74	1615	1	LPS	LPS	NNP
cord-015021-pol2qm74	1615	2	-	-	HYPH
cord-015021-pol2qm74	1615	3	stimulated	stimulate	VBN
cord-015021-pol2qm74	1615	4	monocytes	monocyte	NNS
cord-015021-pol2qm74	1615	5	produced	produce	VBD
cord-015021-pol2qm74	1615	6	87	87	CD
cord-015021-pol2qm74	1615	7	!	!	.
cord-015021-pol2qm74	1616	1	6	6	CD
cord-015021-pol2qm74	1616	2	fM	fm	CD
cord-015021-pol2qm74	1616	3	of	of	IN
cord-015021-pol2qm74	1616	4	ET/106	et/106	NN
cord-015021-pol2qm74	1616	5	cells	cell	NNS
cord-015021-pol2qm74	1616	6	(	(	-LRB-
cord-015021-pol2qm74	1616	7	vs.	vs.	FW
cord-015021-pol2qm74	1616	8	unstimulated	unstimulated	JJ
cord-015021-pol2qm74	1616	9	controls	control	NNS
cord-015021-pol2qm74	1616	10	of	of	IN
cord-015021-pol2qm74	1616	11	<	<	$
cord-015021-pol2qm74	1616	12	25	25	CD
cord-015021-pol2qm74	1616	13	)	)	-RRB-
cord-015021-pol2qm74	1616	14	.	.	.
cord-015021-pol2qm74	1617	1	This	this	DT
cord-015021-pol2qm74	1617	2	calculates	calculate	VBZ
cord-015021-pol2qm74	1617	3	to	to	IN
cord-015021-pol2qm74	1617	4	15	15	CD
cord-015021-pol2qm74	1617	5	-	-	SYM
cord-015021-pol2qm74	1617	6	30	30	CD
cord-015021-pol2qm74	1617	7	%	%	NN
cord-015021-pol2qm74	1617	8	of	of	IN
cord-015021-pol2qm74	1617	9	the	the	DT
cord-015021-pol2qm74	1617	10	amount	amount	NN
cord-015021-pol2qm74	1617	11	of	of	IN
cord-015021-pol2qm74	1617	12	ET	ET	NNP
cord-015021-pol2qm74	1617	13	observed	observe	VBD
cord-015021-pol2qm74	1617	14	in	in	IN
cord-015021-pol2qm74	1617	15	patients	patient	NNS
cord-015021-pol2qm74	1617	16	with	with	IN
cord-015021-pol2qm74	1617	17	low	low	JJ
cord-015021-pol2qm74	1617	18	cardiac	cardiac	JJ
cord-015021-pol2qm74	1617	19	output	output	NN
cord-015021-pol2qm74	1617	20	,	,	,
cord-015021-pol2qm74	1617	21	sepsis	sepsis	NN
cord-015021-pol2qm74	1617	22	or	or	CC
cord-015021-pol2qm74	1617	23	ischemia	ischemia	NN
cord-015021-pol2qm74	1617	24	.	.	.
cord-015021-pol2qm74	1618	1	We	-PRON-	PRP
cord-015021-pol2qm74	1618	2	conclude	conclude	VBP
cord-015021-pol2qm74	1618	3	that	that	IN
cord-015021-pol2qm74	1618	4	ET	ET	NNP
cord-015021-pol2qm74	1618	5	is	be	VBZ
cord-015021-pol2qm74	1618	6	a	a	DT
cord-015021-pol2qm74	1618	7	cytokine	cytokine	NN
cord-015021-pol2qm74	1618	8	produced	produce	VBN
cord-015021-pol2qm74	1618	9	by	by	IN
cord-015021-pol2qm74	1618	10	both	both	DT
cord-015021-pol2qm74	1618	11	EC	EC	NNP
cord-015021-pol2qm74	1618	12	's	's	POS
cord-015021-pol2qm74	1618	13	and	and	CC
cord-015021-pol2qm74	1618	14	monocytes	monocyte	VBZ
cord-015021-pol2qm74	1618	15	with	with	IN
cord-015021-pol2qm74	1618	16	potent	potent	JJ
cord-015021-pol2qm74	1618	17	effects	effect	NNS
cord-015021-pol2qm74	1618	18	on	on	IN
cord-015021-pol2qm74	1618	19	numerous	numerous	JJ
cord-015021-pol2qm74	1618	20	cells	cell	NNS
cord-015021-pol2qm74	1618	21	and	and	CC
cord-015021-pol2qm74	1618	22	organs	organ	NNS
cord-015021-pol2qm74	1618	23	in	in	IN
cord-015021-pol2qm74	1618	24	the	the	DT
cord-015021-pol2qm74	1618	25	critically	critically	RB
cord-015021-pol2qm74	1618	26	ill	ill	JJ
cord-015021-pol2qm74	1618	27	.	.	.
cord-015021-pol2qm74	1619	1	Wuppertal	Wuppertal	NNP
cord-015021-pol2qm74	1619	2	5	5	CD
cord-015021-pol2qm74	1619	3	,	,	,
cord-015021-pol2qm74	1620	1	Germany	Germany	NNP
cord-015021-pol2qm74	1620	2	We	We	NNP
cord-015021-pol2qm74	1620	3	and	and	CC
cord-015021-pol2qm74	1620	4	other	other	JJ
cord-015021-pol2qm74	1620	5	authors	author	NNS
cord-015021-pol2qm74	1620	6	showed	show	VBD
cord-015021-pol2qm74	1620	7	that	that	IN
cord-015021-pol2qm74	1620	8	fatal	fatal	JJ
cord-015021-pol2qm74	1620	9	outcome	outcome	NN
cord-015021-pol2qm74	1620	10	in	in	IN
cord-015021-pol2qm74	1620	11	septic	septic	JJ
cord-015021-pol2qm74	1620	12	disease	disease	NN
cord-015021-pol2qm74	1620	13	is	be	VBZ
cord-015021-pol2qm74	1620	14	associated	associate	VBN
cord-015021-pol2qm74	1620	15	with	with	IN
cord-015021-pol2qm74	1620	16	a	a	DT
cord-015021-pol2qm74	1620	17	decreased	decrease	VBN
cord-015021-pol2qm74	1620	18	capacity	capacity	NN
cord-015021-pol2qm74	1620	19	of	of	IN
cord-015021-pol2qm74	1620	20	peripheral	peripheral	JJ
cord-015021-pol2qm74	1620	21	blood	blood	NN
cord-015021-pol2qm74	1620	22	monocytes	monocyte	NNS
cord-015021-pol2qm74	1620	23	for	for	IN
cord-015021-pol2qm74	1620	24	the	the	DT
cord-015021-pol2qm74	1620	25	in	in	FW
cord-015021-pol2qm74	1620	26	vitro	vitro	FW
cord-015021-pol2qm74	1620	27	production	production	NN
cord-015021-pol2qm74	1620	28	of	of	IN
cord-015021-pol2qm74	1620	29	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	1620	30	cytokines	cytokine	NNS
cord-015021-pol2qm74	1620	31	,	,	,
cord-015021-pol2qm74	1620	32	especially	especially	RB
cord-015021-pol2qm74	1620	33	TNF	tnf	NN
cord-015021-pol2qm74	1620	34	-	-	HYPH
cord-015021-pol2qm74	1620	35	alpha	alpha	NN
cord-015021-pol2qm74	1620	36	.	.	.
cord-015021-pol2qm74	1621	1	We	-PRON-	PRP
cord-015021-pol2qm74	1621	2	found	find	VBD
cord-015021-pol2qm74	1621	3	that	that	IN
cord-015021-pol2qm74	1621	4	this	this	DT
cord-015021-pol2qm74	1621	5	monocytic	monocytic	JJ
cord-015021-pol2qm74	1621	6	deactivation	deactivation	NN
cord-015021-pol2qm74	1621	7	is	be	VBZ
cord-015021-pol2qm74	1621	8	completed	complete	VBN
cord-015021-pol2qm74	1621	9	by	by	IN
cord-015021-pol2qm74	1621	10	a	a	DT
cord-015021-pol2qm74	1621	11	persistent	persistent	JJ
cord-015021-pol2qm74	1621	12	and	and	CC
cord-015021-pol2qm74	1621	13	marked	marked	JJ
cord-015021-pol2qm74	1621	14	decrease	decrease	NN
cord-015021-pol2qm74	1621	15	of	of	IN
cord-015021-pol2qm74	1621	16	HLA	HLA	NNP
cord-015021-pol2qm74	1621	17	-	-	HYPH
cord-015021-pol2qm74	1621	18	DR	DR	NNP
cord-015021-pol2qm74	1621	19	expression	expression	NN
cord-015021-pol2qm74	1621	20	on	on	IN
cord-015021-pol2qm74	1621	21	monocytes	monocyte	NNS
cord-015021-pol2qm74	1621	22	(	(	-LRB-
cord-015021-pol2qm74	1621	23	<	<	NNP
cord-015021-pol2qm74	1621	24	30	30	CD
cord-015021-pol2qm74	1621	25	%	%	NN
cord-015021-pol2qm74	1621	26	HLA	HLA	NNP
cord-015021-pol2qm74	1621	27	-	-	HYPH
cord-015021-pol2qm74	1621	28	DR+	DR+	NNP
cord-015021-pol2qm74	1621	29	monocytes	monocyte	NNS
cord-015021-pol2qm74	1621	30	)	)	-RRB-
cord-015021-pol2qm74	1621	31	and	and	CC
cord-015021-pol2qm74	1621	32	a	a	DT
cord-015021-pol2qm74	1621	33	diminished	diminished	JJ
cord-015021-pol2qm74	1621	34	antigen	antigen	NN
cord-015021-pol2qm74	1621	35	presenting	present	VBG
cord-015021-pol2qm74	1621	36	activity	activity	NN
cord-015021-pol2qm74	1621	37	whereas	whereas	IN
cord-015021-pol2qm74	1621	38	the	the	DT
cord-015021-pol2qm74	1621	39	capacity	capacity	NN
cord-015021-pol2qm74	1621	40	to	to	TO
cord-015021-pol2qm74	1621	41	form	form	VB
cord-015021-pol2qm74	1621	42	the	the	DT
cord-015021-pol2qm74	1621	43	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	1621	44	IL-1	IL-1	NNP
cord-015021-pol2qm74	1621	45	receptor	receptor	NN
cord-015021-pol2qm74	1621	46	antagonist	antagonist	NN
cord-015021-pol2qm74	1621	47	remains	remain	VBZ
cord-015021-pol2qm74	1621	48	high	high	JJ
cord-015021-pol2qm74	1621	49	.	.	.
cord-015021-pol2qm74	1622	1	In	in	IN
cord-015021-pol2qm74	1622	2	order	order	NN
cord-015021-pol2qm74	1622	3	to	to	TO
cord-015021-pol2qm74	1622	4	evaluate	evaluate	VB
cord-015021-pol2qm74	1622	5	the	the	DT
cord-015021-pol2qm74	1622	6	in	in	IN
cord-015021-pol2qm74	1622	7	vivo	vivo	NN
cord-015021-pol2qm74	1622	8	situation	situation	NN
cord-015021-pol2qm74	1622	9	and	and	CC
cord-015021-pol2qm74	1622	10	to	to	TO
cord-015021-pol2qm74	1622	11	determine	determine	VB
cord-015021-pol2qm74	1622	12	at	at	IN
cord-015021-pol2qm74	1622	13	which	which	WDT
cord-015021-pol2qm74	1622	14	level	level	NN
cord-015021-pol2qm74	1622	15	TNFproduction	tnfproduction	NN
cord-015021-pol2qm74	1622	16	/	/	,
cord-015021-pol2qm74	1622	17	secretion	secretion	NN
cord-015021-pol2qm74	1622	18	is	be	VBZ
cord-015021-pol2qm74	1622	19	altered	alter	VBN
cord-015021-pol2qm74	1622	20	we	-PRON-	PRP
cord-015021-pol2qm74	1622	21	assessed	assess	VBD
cord-015021-pol2qm74	1622	22	the	the	DT
cord-015021-pol2qm74	1622	23	TNF	TNF	NNP
cord-015021-pol2qm74	1622	24	-	-	HYPH
cord-015021-pol2qm74	1622	25	alpha	alpha	NN
cord-015021-pol2qm74	1622	26	mRNA	mRNA	NNP
cord-015021-pol2qm74	1622	27	expression	expression	NN
cord-015021-pol2qm74	1622	28	in	in	IN
cord-015021-pol2qm74	1622	29	freshly	freshly	RB
cord-015021-pol2qm74	1622	30	isolated	isolate	VBN
cord-015021-pol2qm74	1622	31	peripheral	peripheral	JJ
cord-015021-pol2qm74	1622	32	blood	blood	NN
cord-015021-pol2qm74	1622	33	mononuclear	mononuclear	NN
cord-015021-pol2qm74	1622	34	cells	cell	NNS
cord-015021-pol2qm74	1622	35	(	(	-LRB-
cord-015021-pol2qm74	1622	36	PBMNC	PBMNC	NNP
cord-015021-pol2qm74	1622	37	)	)	-RRB-
cord-015021-pol2qm74	1622	38	from	from	IN
cord-015021-pol2qm74	1622	39	septic	septic	JJ
cord-015021-pol2qm74	1622	40	patients	patient	NNS
cord-015021-pol2qm74	1622	41	.	.	.
cord-015021-pol2qm74	1623	1	TNF	TNF	NNP
cord-015021-pol2qm74	1623	2	-	-	HYPH
cord-015021-pol2qm74	1623	3	mRNA	mRNA	NNP
cord-015021-pol2qm74	1623	4	was	be	VBD
cord-015021-pol2qm74	1623	5	onty	onty	JJ
cord-015021-pol2qm74	1623	6	rarely	rarely	RB
cord-015021-pol2qm74	1623	7	detected	detect	VBN
cord-015021-pol2qm74	1623	8	by	by	IN
cord-015021-pol2qm74	1623	9	semiqaantitative	semiqaantitative	JJ
cord-015021-pol2qm74	1623	10	polymerase	polymerase	NN
cord-015021-pol2qm74	1623	11	chain	chain	NN
cord-015021-pol2qm74	1623	12	reaction	reaction	NN
cord-015021-pol2qm74	1623	13	in	in	IN
cord-015021-pol2qm74	1623	14	PBMNC	PBMNC	NNP
cord-015021-pol2qm74	1623	15	's	's	POS
cord-015021-pol2qm74	1623	16	from	from	IN
cord-015021-pol2qm74	1623	17	septic	septic	JJ
cord-015021-pol2qm74	1623	18	patients	patient	NNS
cord-015021-pol2qm74	1623	19	with	with	IN
cord-015021-pol2qm74	1623	20	monocyte	monocyte	NNP
cord-015021-pol2qm74	1623	21	deactivation	deactivation	NN
cord-015021-pol2qm74	1623	22	.	.	.
cord-015021-pol2qm74	1624	1	Meanwhile	meanwhile	RB
cord-015021-pol2qm74	1624	2	,	,	,
cord-015021-pol2qm74	1624	3	it	-PRON-	PRP
cord-015021-pol2qm74	1624	4	was	be	VBD
cord-015021-pol2qm74	1624	5	found	find	VBN
cord-015021-pol2qm74	1624	6	in	in	IN
cord-015021-pol2qm74	1624	7	almost	almost	RB
cord-015021-pol2qm74	1624	8	all	all	DT
cord-015021-pol2qm74	1624	9	PBMNCs	pbmnc	NNS
cord-015021-pol2qm74	1624	10	from	from	IN
cord-015021-pol2qm74	1624	11	septic	septic	JJ
cord-015021-pol2qm74	1624	12	patients	patient	NNS
cord-015021-pol2qm74	1624	13	without	without	IN
cord-015021-pol2qm74	1624	14	monocytic	monocytic	JJ
cord-015021-pol2qm74	1624	15	deactivation	deactivation	NN
cord-015021-pol2qm74	1624	16	.	.	.
cord-015021-pol2qm74	1625	1	We	-PRON-	PRP
cord-015021-pol2qm74	1625	2	wondered	wonder	VBD
cord-015021-pol2qm74	1625	3	,	,	,
cord-015021-pol2qm74	1625	4	whether	whether	IN
cord-015021-pol2qm74	1625	5	IL	IL	NNP
cord-015021-pol2qm74	1625	6	-	-	HYPH
cord-015021-pol2qm74	1625	7	I0	I0	NNP
cord-015021-pol2qm74	1625	8	,	,	,
cord-015021-pol2qm74	1625	9	which	which	WDT
cord-015021-pol2qm74	1625	10	,	,	,
cord-015021-pol2qm74	1625	11	is	be	VBZ
cord-015021-pol2qm74	1625	12	known	know	VBN
cord-015021-pol2qm74	1625	13	to	to	TO
cord-015021-pol2qm74	1625	14	depress	depress	VB
cord-015021-pol2qm74	1625	15	monocytic	monocytic	JJ
cord-015021-pol2qm74	1625	16	proinflammatoly	proinflammatoly	JJ
cord-015021-pol2qm74	1625	17	response	response	NN
cord-015021-pol2qm74	1625	18	and	and	CC
cord-015021-pol2qm74	1625	19	MHC	MHC	NNP
cord-015021-pol2qm74	1625	20	class	class	NN
cord-015021-pol2qm74	1625	21	II	II	NNP
cord-015021-pol2qm74	1625	22	expression	expression	NN
cord-015021-pol2qm74	1625	23	,	,	,
cord-015021-pol2qm74	1625	24	could	could	MD
cord-015021-pol2qm74	1625	25	be	be	VB
cord-015021-pol2qm74	1625	26	one	one	CD
cord-015021-pol2qm74	1625	27	of	of	IN
cord-015021-pol2qm74	1625	28	the	the	DT
cord-015021-pol2qm74	1625	29	mediators	mediator	NNS
cord-015021-pol2qm74	1625	30	in	in	IN
cord-015021-pol2qm74	1625	31	fatal	fatal	JJ
cord-015021-pol2qm74	1625	32	sepsis	sepsis	NN
cord-015021-pol2qm74	1625	33	.	.	.
cord-015021-pol2qm74	1626	1	In	in	IN
cord-015021-pol2qm74	1626	2	fact	fact	NN
cord-015021-pol2qm74	1626	3	,	,	,
cord-015021-pol2qm74	1626	4	we	-PRON-	PRP
cord-015021-pol2qm74	1626	5	found	find	VBD
cord-015021-pol2qm74	1626	6	that	that	IN
cord-015021-pol2qm74	1626	7	IL-10	IL-10	NNP
cord-015021-pol2qm74	1626	8	message	message	NN
cord-015021-pol2qm74	1626	9	in	in	IN
cord-015021-pol2qm74	1626	10	PBMNCs	pbmnc	NNS
cord-015021-pol2qm74	1626	11	of	of	IN
cord-015021-pol2qm74	1626	12	septic	septic	JJ
cord-015021-pol2qm74	1626	13	patients	patient	NNS
cord-015021-pol2qm74	1626	14	peaked	peak	VBD
cord-015021-pol2qm74	1626	15	in	in	IN
cord-015021-pol2qm74	1626	16	the	the	DT
cord-015021-pol2qm74	1626	17	beginning	beginning	NN
cord-015021-pol2qm74	1626	18	phase	phase	NN
cord-015021-pol2qm74	1626	19	of	of	IN
cord-015021-pol2qm74	1626	20	monocytic	monocytic	JJ
cord-015021-pol2qm74	1626	21	deactivation	deactivation	NN
cord-015021-pol2qm74	1626	22	.	.	.
cord-015021-pol2qm74	1627	1	In	in	IN
cord-015021-pol2qm74	1627	2	further	further	JJ
cord-015021-pol2qm74	1627	3	investigations	investigation	NNS
cord-015021-pol2qm74	1627	4	we	-PRON-	PRP
cord-015021-pol2qm74	1627	5	found	find	VBD
cord-015021-pol2qm74	1627	6	that	that	IN
cord-015021-pol2qm74	1627	7	TNF	TNF	NNP
cord-015021-pol2qm74	1627	8	-	-	HYPH
cord-015021-pol2qm74	1627	9	administration	administration	NN
cord-015021-pol2qm74	1627	10	can	can	MD
cord-015021-pol2qm74	1627	11	induce	induce	VB
cord-015021-pol2qm74	1627	12	monocytic	monocytic	JJ
cord-015021-pol2qm74	1627	13	deactivation	deactivation	NN
cord-015021-pol2qm74	1627	14	in	in	IN
cord-015021-pol2qm74	1627	15	a	a	DT
cord-015021-pol2qm74	1627	16	murine	murine	JJ
cord-015021-pol2qm74	1627	17	model	model	NN
cord-015021-pol2qm74	1627	18	/	/	SYM
cord-015021-pol2qm74	1627	19	n	n	NN
cord-015021-pol2qm74	1627	20	vivo	vivo	NN
cord-015021-pol2qm74	1627	21	and	and	CC
cord-015021-pol2qm74	1627	22	provoke	provoke	VB
cord-015021-pol2qm74	1627	23	IL-10	IL-10	NNP
cord-015021-pol2qm74	1627	24	message	message	NN
cord-015021-pol2qm74	1627	25	in	in	IN
cord-015021-pol2qm74	1627	26	human	human	JJ
cord-015021-pol2qm74	1627	27	PBMNCs	pbmnc	NNS
cord-015021-pol2qm74	1627	28	in	in	IN
cord-015021-pol2qm74	1627	29	vitro	vitro	FW
cord-015021-pol2qm74	1627	30	.	.	.
cord-015021-pol2qm74	1628	1	These	these	DT
cord-015021-pol2qm74	1628	2	results	result	NNS
cord-015021-pol2qm74	1628	3	support	support	VBP
cord-015021-pol2qm74	1628	4	our	-PRON-	PRP$
cord-015021-pol2qm74	1628	5	hypothesis	hypothesis	NN
cord-015021-pol2qm74	1628	6	that	that	IN
cord-015021-pol2qm74	1628	7	an	an	DT
cord-015021-pol2qm74	1628	8	excessive	excessive	JJ
cord-015021-pol2qm74	1628	9	delivery	delivery	NN
cord-015021-pol2qm74	1628	10	of	of	IN
cord-015021-pol2qm74	1628	11	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	1628	12	cytokines	cytokine	NNS
cord-015021-pol2qm74	1628	13	in	in	IN
cord-015021-pol2qm74	1628	14	a	a	DT
cord-015021-pol2qm74	1628	15	first	first	JJ
cord-015021-pol2qm74	1628	16	phase	phase	NN
cord-015021-pol2qm74	1628	17	can	can	MD
cord-015021-pol2qm74	1628	18	induce	induce	VB
cord-015021-pol2qm74	1628	19	an	an	DT
cord-015021-pol2qm74	1628	20	overwheiming	overwheiming	JJ
cord-015021-pol2qm74	1628	21	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1628	22	feedback	feedback	NN
cord-015021-pol2qm74	1628	23	,	,	,
cord-015021-pol2qm74	1628	24	mediated	mediate	VBN
cord-015021-pol2qm74	1628	25	by	by	IN
cord-015021-pol2qm74	1628	26	immuninhibitory	immuninhibitory	JJ
cord-015021-pol2qm74	1628	27	mediators	mediator	NNS
cord-015021-pol2qm74	1628	28	like	like	IN
cord-015021-pol2qm74	1628	29	IL	IL	NNP
cord-015021-pol2qm74	1628	30	-	-	HYPH
cord-015021-pol2qm74	1628	31	l0	l0	NNP
cord-015021-pol2qm74	1628	32	,	,	,
cord-015021-pol2qm74	1628	33	which	which	WDT
cord-015021-pol2qm74	1628	34	leads	lead	VBZ
cord-015021-pol2qm74	1628	35	to	to	TO
cord-015021-pol2qm74	1628	36	often	often	RB
cord-015021-pol2qm74	1628	37	fatal	fatal	JJ
cord-015021-pol2qm74	1628	38	monocytic	monocytic	JJ
cord-015021-pol2qm74	1628	39	deactivation	deactivation	NN
cord-015021-pol2qm74	1628	40	in	in	IN
cord-015021-pol2qm74	1628	41	a	a	DT
cord-015021-pol2qm74	1628	42	second	second	JJ
cord-015021-pol2qm74	1628	43	phase	phase	NN
cord-015021-pol2qm74	1628	44	.	.	.
cord-015021-pol2qm74	1629	1	Interferon	interferon	NN
cord-015021-pol2qm74	1629	2	-	-	HYPH
cord-015021-pol2qm74	1629	3	gamma	gamma	NN
cord-015021-pol2qm74	1629	4	which	which	WDT
cord-015021-pol2qm74	1629	5	is	be	VBZ
cord-015021-pol2qm74	1629	6	known	know	VBN
cord-015021-pol2qm74	1629	7	to	to	TO
cord-015021-pol2qm74	1629	8	counteract	counteract	VB
cord-015021-pol2qm74	1629	9	IL-10	IL-10	NNP
cord-015021-pol2qm74	1629	10	production	production	NN
cord-015021-pol2qm74	1629	11	and	and	CC
cord-015021-pol2qm74	1629	12	the	the	DT
cord-015021-pol2qm74	1629	13	effects	effect	NNS
cord-015021-pol2qm74	1629	14	of	of	IN
cord-015021-pol2qm74	1629	15	IL-10	IL-10	NNP
cord-015021-pol2qm74	1629	16	on	on	IN
cord-015021-pol2qm74	1629	17	monocytes	monocyte	NNS
cord-015021-pol2qm74	1629	18	restores	restore	VBZ
cord-015021-pol2qm74	1629	19	the	the	DT
cord-015021-pol2qm74	1629	20	function	function	NN
cord-015021-pol2qm74	1629	21	and	and	CC
cord-015021-pol2qm74	1629	22	phenotype	phenotype	NN
cord-015021-pol2qm74	1629	23	of	of	IN
cord-015021-pol2qm74	1629	24	monocytes	monocyte	NNS
cord-015021-pol2qm74	1629	25	from	from	IN
cord-015021-pol2qm74	1629	26	septic	septic	JJ
cord-015021-pol2qm74	1629	27	patients	patient	NNS
cord-015021-pol2qm74	1629	28	with	with	IN
cord-015021-pol2qm74	1629	29	monoq	monoq	NNP
cord-015021-pol2qm74	1629	30	,	,	,
cord-015021-pol2qm74	1629	31	te	te	NNP
cord-015021-pol2qm74	1629	32	deactivation	deactivation	NN
cord-015021-pol2qm74	1629	33	in	in	IN
cord-015021-pol2qm74	1629	34	vitro	vitro	FW
cord-015021-pol2qm74	1629	35	and	and	CC
cord-015021-pol2qm74	1629	36	could	could	MD
cord-015021-pol2qm74	1629	37	be	be	VB
cord-015021-pol2qm74	1629	38	a	a	DT
cord-015021-pol2qm74	1629	39	possible	possible	JJ
cord-015021-pol2qm74	1629	40	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1629	41	agent	agent	NN
cord-015021-pol2qm74	1629	42	in	in	IN
cord-015021-pol2qm74	1629	43	otherwise	otherwise	RB
cord-015021-pol2qm74	1629	44	fatal	fatal	JJ
cord-015021-pol2qm74	1629	45	sepsis	sepsis	NN
cord-015021-pol2qm74	1629	46	.	.	.
cord-015021-pol2qm74	1630	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	1630	2	laboratory	laboratory	NN
cord-015021-pol2qm74	1630	3	previously	previously	RB
cord-015021-pol2qm74	1630	4	reported	report	VBD
cord-015021-pol2qm74	1630	5	that	that	IN
cord-015021-pol2qm74	1630	6	LPS	LPS	NNP
cord-015021-pol2qm74	1630	7	dependent	dependent	JJ
cord-015021-pol2qm74	1630	8	macrophagederived	macrophagederive	VBD
cord-015021-pol2qm74	1630	9	TNF	TNF	NNP
cord-015021-pol2qm74	1630	10	-	-	:
cord-015021-pol2qm74	1630	11	a	a	DT
cord-015021-pol2qm74	1630	12	production	production	NN
cord-015021-pol2qm74	1630	13	can	can	MD
cord-015021-pol2qm74	1630	14	be	be	VB
cord-015021-pol2qm74	1630	15	enhanced	enhance	VBN
cord-015021-pol2qm74	1630	16	by	by	IN
cord-015021-pol2qm74	1630	17	pretreatment	pretreatment	NN
cord-015021-pol2qm74	1630	18	with	with	IN
cord-015021-pol2qm74	1630	19	LPS	LPS	NNP
cord-015021-pol2qm74	1630	20	at	at	IN
cord-015021-pol2qm74	1630	21	substimulatory	substimulatory	NN
cord-015021-pol2qm74	1630	22	LPS	lp	NNS
cord-015021-pol2qm74	1630	23	priming	prime	VBG
cord-015021-pol2qm74	1630	24	doses	dose	NNS
cord-015021-pol2qm74	1630	25	coincident	coincident	JJ
cord-015021-pol2qm74	1630	26	with	with	IN
cord-015021-pol2qm74	1630	27	a	a	DT
cord-015021-pol2qm74	1630	28	suppression	suppression	NN
cord-015021-pol2qm74	1630	29	of	of	IN
cord-015021-pol2qm74	1630	30	LPS	LPS	NNP
cord-015021-pol2qm74	1630	31	dependent	dependent	JJ
cord-015021-pol2qm74	1630	32	nitric	nitric	NN
cord-015021-pol2qm74	1630	33	oxide	oxide	NN
cord-015021-pol2qm74	1630	34	(	(	-LRB-
cord-015021-pol2qm74	1630	35	NO	no	UH
cord-015021-pol2qm74	1630	36	)	)	-RRB-
cord-015021-pol2qm74	1630	37	production	production	NN
cord-015021-pol2qm74	1630	38	(	(	-LRB-
cord-015021-pol2qm74	1630	39	Zhang	Zhang	NNP
cord-015021-pol2qm74	1630	40	and	and	CC
cord-015021-pol2qm74	1630	41	Morrison	Morrison	NNP
cord-015021-pol2qm74	1630	42	,	,	,
cord-015021-pol2qm74	1630	43	J.	J.	NNP
cord-015021-pol2qm74	1630	44	Exp	Exp	NNP
cord-015021-pol2qm74	1630	45	.	.	.
cord-015021-pol2qm74	1631	1	Med	Med	NNP
cord-015021-pol2qm74	1631	2	17:511	17:511	CD
cord-015021-pol2qm74	1631	3	,	,	,
cord-015021-pol2qm74	1631	4	1993	1993	CD
cord-015021-pol2qm74	1631	5	)	)	-RRB-
cord-015021-pol2qm74	1631	6	.	.	.
cord-015021-pol2qm74	1632	1	In	in	IN
cord-015021-pol2qm74	1632	2	order	order	NN
cord-015021-pol2qm74	1632	3	to	to	TO
cord-015021-pol2qm74	1632	4	extend	extend	VB
cord-015021-pol2qm74	1632	5	the	the	DT
cord-015021-pol2qm74	1632	6	characterization	characterization	NN
cord-015021-pol2qm74	1632	7	of	of	IN
cord-015021-pol2qm74	1632	8	these	these	DT
cord-015021-pol2qm74	1632	9	LPS	lp	NNS
cord-015021-pol2qm74	1632	10	priming	prime	VBG
cord-015021-pol2qm74	1632	11	effects	effect	NNS
cord-015021-pol2qm74	1632	12	in	in	IN
cord-015021-pol2qm74	1632	13	mouse	mouse	NN
cord-015021-pol2qm74	1632	14	macrophages	macrophage	NNS
cord-015021-pol2qm74	1632	15	,	,	,
cord-015021-pol2qm74	1632	16	we	-PRON-	PRP
cord-015021-pol2qm74	1632	17	examined	examine	VBD
cord-015021-pol2qm74	1632	18	the	the	DT
cord-015021-pol2qm74	1632	19	capacity	capacity	NN
cord-015021-pol2qm74	1632	20	of	of	IN
cord-015021-pol2qm74	1632	21	substimulatory	substimulatory	NN
cord-015021-pol2qm74	1632	22	LPS	LPS	NNP
cord-015021-pol2qm74	1632	23	to	to	TO
cord-015021-pol2qm74	1632	24	modify	modify	VB
cord-015021-pol2qm74	1632	25	LPS	LPS	NNP
cord-015021-pol2qm74	1632	26	dependent	dependent	JJ
cord-015021-pol2qm74	1632	27	IL-6	IL-6	NNP
cord-015021-pol2qm74	1632	28	production	production	NN
cord-015021-pol2qm74	1632	29	.	.	.
cord-015021-pol2qm74	1633	1	Macrophages	macrophage	NNS
cord-015021-pol2qm74	1633	2	were	be	VBD
cord-015021-pol2qm74	1633	3	obtained	obtain	VBN
cord-015021-pol2qm74	1633	4	from	from	IN
cord-015021-pol2qm74	1633	5	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	1633	6	exudate	exudate	NN
cord-015021-pol2qm74	1633	7	of	of	IN
cord-015021-pol2qm74	1633	8	thioglycollate	thioglycollate	NNP
cord-015021-pol2qm74	1633	9	treated	treat	VBN
cord-015021-pol2qm74	1633	10	C3Heb	C3Heb	NNP
cord-015021-pol2qm74	1633	11	/	/	SYM
cord-015021-pol2qm74	1633	12	FeJ	fej	NN
cord-015021-pol2qm74	1633	13	mice	mouse	NNS
cord-015021-pol2qm74	1633	14	and	and	CC
cord-015021-pol2qm74	1633	15	cultured	culture	VBN
cord-015021-pol2qm74	1633	16	in	in	IN
cord-015021-pol2qm74	1633	17	RPMI	RPMI	NNP
cord-015021-pol2qm74	1633	18	1640	1640	CD
cord-015021-pol2qm74	1633	19	medium	medium	NN
cord-015021-pol2qm74	1633	20	containing	contain	VBG
cord-015021-pol2qm74	1633	21	10	10	CD
cord-015021-pol2qm74	1633	22	%	%	NN
cord-015021-pol2qm74	1633	23	fetal	fetal	JJ
cord-015021-pol2qm74	1633	24	bovine	bovine	JJ
cord-015021-pol2qm74	1633	25	serum	serum	NN
cord-015021-pol2qm74	1633	26	.	.	.
cord-015021-pol2qm74	1634	1	Macrophages	macrophage	NNS
cord-015021-pol2qm74	1634	2	were	be	VBD
cord-015021-pol2qm74	1634	3	pretreated	pretreate	VBN
cord-015021-pol2qm74	1634	4	with	with	IN
cord-015021-pol2qm74	1634	5	various	various	JJ
cord-015021-pol2qm74	1634	6	subthreshold	subthreshold	NN
cord-015021-pol2qm74	1634	7	stimulatory	stimulatory	JJ
cord-015021-pol2qm74	1634	8	concentrations	concentration	NNS
cord-015021-pol2qm74	1634	9	of	of	IN
cord-015021-pol2qm74	1634	10	LPS	LPS	NNP
cord-015021-pol2qm74	1634	11	(	(	-LRB-
cord-015021-pol2qm74	1634	12	Olll	Olll	NNP
cord-015021-pol2qm74	1634	13	:	:	:
cord-015021-pol2qm74	1634	14	B4	B4	NNP
cord-015021-pol2qm74	1634	15	)	)	-RRB-
cord-015021-pol2qm74	1634	16	for	for	IN
cord-015021-pol2qm74	1634	17	6	6	CD
cord-015021-pol2qm74	1634	18	hours	hour	NNS
cord-015021-pol2qm74	1634	19	,	,	,
cord-015021-pol2qm74	1634	20	washed	wash	VBD
cord-015021-pol2qm74	1634	21	three	three	CD
cord-015021-pol2qm74	1634	22	times	time	NNS
cord-015021-pol2qm74	1634	23	,	,	,
cord-015021-pol2qm74	1634	24	and	and	CC
cord-015021-pol2qm74	1634	25	then	then	RB
cord-015021-pol2qm74	1634	26	stimulated	stimulate	VBD
cord-015021-pol2qm74	1634	27	with	with	IN
cord-015021-pol2qm74	1634	28	the	the	DT
cord-015021-pol2qm74	1634	29	effective	effective	JJ
cord-015021-pol2qm74	1634	30	stimulatory	stimulatory	JJ
cord-015021-pol2qm74	1634	31	concentration	concentration	NN
cord-015021-pol2qm74	1634	32	of	of	IN
cord-015021-pol2qm74	1634	33	LPS	LPS	NNP
cord-015021-pol2qm74	1634	34	for	for	IN
cord-015021-pol2qm74	1634	35	18	18	CD
cord-015021-pol2qm74	1634	36	hours	hour	NNS
cord-015021-pol2qm74	1634	37	.	.	.
cord-015021-pol2qm74	1635	1	The	the	DT
cord-015021-pol2qm74	1635	2	amount	amount	NN
cord-015021-pol2qm74	1635	3	of	of	IN
cord-015021-pol2qm74	1635	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	1635	5	in	in	IN
cord-015021-pol2qm74	1635	6	the	the	DT
cord-015021-pol2qm74	1635	7	supernatant	supernatant	NN
cord-015021-pol2qm74	1635	8	was	be	VBD
cord-015021-pol2qm74	1635	9	measured	measure	VBN
cord-015021-pol2qm74	1635	10	by	by	IN
cord-015021-pol2qm74	1635	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	1635	12	dependent	dependent	JJ
cord-015021-pol2qm74	1635	13	cell	cell	NN
cord-015021-pol2qm74	1635	14	line	line	NN
cord-015021-pol2qm74	1635	15	(	(	-LRB-
cord-015021-pol2qm74	1635	16	B9	b9	NN
cord-015021-pol2qm74	1635	17	and	and	CC
cord-015021-pol2qm74	1635	18	7TD1	7td1	CD
cord-015021-pol2qm74	1635	19	)	)	-RRB-
cord-015021-pol2qm74	1635	20	proliferation	proliferation	NN
cord-015021-pol2qm74	1635	21	assay	assay	NN
cord-015021-pol2qm74	1635	22	.	.	.
cord-015021-pol2qm74	1636	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	1636	2	was	be	VBD
cord-015021-pol2qm74	1636	3	produced	produce	VBN
cord-015021-pol2qm74	1636	4	by	by	IN
cord-015021-pol2qm74	1636	5	macrophages	macrophage	NNS
cord-015021-pol2qm74	1636	6	at	at	IN
cord-015021-pol2qm74	1636	7	lower	low	JJR
cord-015021-pol2qm74	1636	8	threshold	threshold	NN
cord-015021-pol2qm74	1636	9	doses	dose	NNS
cord-015021-pol2qm74	1636	10	of	of	IN
cord-015021-pol2qm74	1636	11	LPS	lp	NNS
cord-015021-pol2qm74	1636	12	than	than	IN
cord-015021-pol2qm74	1636	13	those	those	DT
cord-015021-pol2qm74	1636	14	required	require	VBN
cord-015021-pol2qm74	1636	15	for	for	IN
cord-015021-pol2qm74	1636	16	TNF	TNF	NNP
cord-015021-pol2qm74	1636	17	-	-	HYPH
cord-015021-pol2qm74	1636	18	o~	o~	NNP
cord-015021-pol2qm74	1636	19	or	or	CC
cord-015021-pol2qm74	1636	20	NO	no	DT
cord-015021-pol2qm74	1636	21	production	production	NN
cord-015021-pol2qm74	1636	22	.	.	.
cord-015021-pol2qm74	1637	1	Subthreshold	Subthreshold	NNP
cord-015021-pol2qm74	1637	2	doses	dose	NNS
cord-015021-pol2qm74	1637	3	of	of	IN
cord-015021-pol2qm74	1637	4	LPS	LPS	NNP
cord-015021-pol2qm74	1637	5	modulated	modulate	VBD
cord-015021-pol2qm74	1637	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	1637	7	production	production	NN
cord-015021-pol2qm74	1637	8	in	in	IN
cord-015021-pol2qm74	1637	9	a	a	DT
cord-015021-pol2qm74	1637	10	biphasic	biphasic	JJ
cord-015021-pol2qm74	1637	11	manner	manner	NN
cord-015021-pol2qm74	1637	12	characterized	characterize	VBN
cord-015021-pol2qm74	1637	13	by	by	IN
cord-015021-pol2qm74	1637	14	an	an	DT
cord-015021-pol2qm74	1637	15	initial	initial	JJ
cord-015021-pol2qm74	1637	16	suppression	suppression	NN
cord-015021-pol2qm74	1637	17	and	and	CC
cord-015021-pol2qm74	1637	18	then	then	RB
cord-015021-pol2qm74	1637	19	potentiation	potentiation	NN
cord-015021-pol2qm74	1637	20	.	.	.
cord-015021-pol2qm74	1638	1	Higher	high	JJR
cord-015021-pol2qm74	1638	2	doses	dose	NNS
cord-015021-pol2qm74	1638	3	resulted	result	VBD
cord-015021-pol2qm74	1638	4	in	in	IN
cord-015021-pol2qm74	1638	5	secretion	secretion	NN
cord-015021-pol2qm74	1638	6	of	of	IN
cord-015021-pol2qm74	1638	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	1638	8	during	during	IN
cord-015021-pol2qm74	1638	9	the	the	DT
cord-015021-pol2qm74	1638	10	initial	initial	JJ
cord-015021-pol2qm74	1638	11	incubation	incubation	NN
cord-015021-pol2qm74	1638	12	with	with	IN
cord-015021-pol2qm74	1638	13	LPS	LPS	NNP
cord-015021-pol2qm74	1638	14	and	and	CC
cord-015021-pol2qm74	1638	15	subsequent	subsequent	JJ
cord-015021-pol2qm74	1638	16	desensitization	desensitization	NN
cord-015021-pol2qm74	1638	17	.	.	.
cord-015021-pol2qm74	1639	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	1639	2	,	,	,
cord-015021-pol2qm74	1639	3	like	like	IN
cord-015021-pol2qm74	1639	4	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	1639	5	and	and	CC
cord-015021-pol2qm74	1639	6	NO	no	UH
cord-015021-pol2qm74	1639	7	,	,	,
cord-015021-pol2qm74	1639	8	is	be	VBZ
cord-015021-pol2qm74	1639	9	,	,	,
cord-015021-pol2qm74	1639	10	therefore	therefore	RB
cord-015021-pol2qm74	1639	11	,	,	,
cord-015021-pol2qm74	1639	12	also	also	RB
cord-015021-pol2qm74	1639	13	affected	affect	VBN
cord-015021-pol2qm74	1639	14	by	by	IN
cord-015021-pol2qm74	1639	15	LPS	LPS	NNP
cord-015021-pol2qm74	1639	16	pretreatment	pretreatment	NN
cord-015021-pol2qm74	1639	17	.	.	.
cord-015021-pol2qm74	1640	1	Moreover	moreover	RB
cord-015021-pol2qm74	1640	2	,	,	,
cord-015021-pol2qm74	1640	3	TNF	TNF	NNP
cord-015021-pol2qm74	1640	4	-	-	:
cord-015021-pol2qm74	1640	5	a	a	NNP
cord-015021-pol2qm74	1640	6	and	and	CC
cord-015021-pol2qm74	1640	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	1640	8	shared	share	VBD
cord-015021-pol2qm74	1640	9	the	the	DT
cord-015021-pol2qm74	1640	10	similar	similar	JJ
cord-015021-pol2qm74	1640	11	potentiational	potentiational	JJ
cord-015021-pol2qm74	1640	12	pathway	pathway	NN
cord-015021-pol2qm74	1640	13	,	,	,
cord-015021-pol2qm74	1640	14	but	but	CC
cord-015021-pol2qm74	1640	15	differed	differ	VBN
cord-015021-pol2qm74	1640	16	by	by	IN
cord-015021-pol2qm74	1640	17	the	the	DT
cord-015021-pol2qm74	1640	18	fact	fact	NN
cord-015021-pol2qm74	1640	19	that	that	IN
cord-015021-pol2qm74	1640	20	only	only	RB
cord-015021-pol2qm74	1640	21	IL-6	IL-6	NNP
cord-015021-pol2qm74	1640	22	was	be	VBD
cord-015021-pol2qm74	1640	23	inhibited	inhibit	VBN
cord-015021-pol2qm74	1640	24	.	.	.
cord-015021-pol2qm74	1641	1	(	(	-LRB-
cord-015021-pol2qm74	1641	2	Supported	support	VBN
cord-015021-pol2qm74	1641	3	by	by	IN
cord-015021-pol2qm74	1641	4	R37	R37	NNP
cord-015021-pol2qm74	1641	5	AI23447	AI23447	NNP
cord-015021-pol2qm74	1641	6	and	and	CC
cord-015021-pol2qm74	1641	7	PO1	PO1	NNP
cord-015021-pol2qm74	1641	8	A54474	A54474	NNP
cord-015021-pol2qm74	1641	9	.	.	.
cord-015021-pol2qm74	1641	10	)	)	-RRB-
cord-015021-pol2qm74	1642	1	Department	Department	NNP
cord-015021-pol2qm74	1642	2	of	of	IN
cord-015021-pol2qm74	1642	3	Microbiology	Microbiology	NNP
cord-015021-pol2qm74	1642	4	,	,	,
cord-015021-pol2qm74	1642	5	Molecular	Molecular	NNP
cord-015021-pol2qm74	1642	6	Genetics	Genetics	NNP
cord-015021-pol2qm74	1642	7	and	and	CC
cord-015021-pol2qm74	1642	8	Immunology	Immunology	NNP
cord-015021-pol2qm74	1642	9	and	and	CC
cord-015021-pol2qm74	1642	10	the	the	DT
cord-015021-pol2qm74	1642	11	Cancer	Cancer	NNP
cord-015021-pol2qm74	1642	12	Center	Center	NNP
cord-015021-pol2qm74	1642	13	,	,	,
cord-015021-pol2qm74	1642	14	1000	1000	CD
cord-015021-pol2qm74	1642	15	Wahl	Wahl	NNP
cord-015021-pol2qm74	1642	16	East	East	NNP
cord-015021-pol2qm74	1642	17	,	,	,
cord-015021-pol2qm74	1642	18	University	University	NNP
cord-015021-pol2qm74	1642	19	of	of	IN
cord-015021-pol2qm74	1642	20	Kansas	Kansas	NNP
cord-015021-pol2qm74	1642	21	Medical	Medical	NNP
cord-015021-pol2qm74	1642	22	Center	Center	NNP
cord-015021-pol2qm74	1642	23	,	,	,
cord-015021-pol2qm74	1642	24	Kansas	Kansas	NNP
cord-015021-pol2qm74	1642	25	City	City	NNP
cord-015021-pol2qm74	1642	26	,	,	,
cord-015021-pol2qm74	1642	27	KS	KS	NNP
cord-015021-pol2qm74	1642	28	66160	66160	CD
cord-015021-pol2qm74	1642	29	-	-	HYPH
cord-015021-pol2qm74	1642	30	7832	7832	CD
cord-015021-pol2qm74	1642	31	.	.	.
cord-015021-pol2qm74	1643	1	Korolenko	Korolenko	NNP
cord-015021-pol2qm74	1643	2	T.,Urazgaliev	T.,Urazgaliev	NNP
cord-015021-pol2qm74	1643	3	K.,and	K.,and	NNP
cord-015021-pol2qm74	1643	4	Arkhipov	Arkhipov	NNPS
cord-015021-pol2qm74	1643	5	S.	S.	NNP
cord-015021-pol2qm74	1644	1	The	the	DT
cord-015021-pol2qm74	1644	2	role	role	NN
cord-015021-pol2qm74	1644	3	of	of	IN
cord-015021-pol2qm74	1644	4	macrophage	macrophage	NN
cord-015021-pol2qm74	1644	5	(	(	-LRB-
cord-015021-pol2qm74	1644	6	Mph	Mph	NNP
cord-015021-pol2qm74	1644	7	)	)	-RRB-
cord-015021-pol2qm74	1644	8	stimulation	stimulation	NN
cord-015021-pol2qm74	1644	9	in	in	IN
cord-015021-pol2qm74	1644	10	mechanism	mechanism	NN
cord-015021-pol2qm74	1644	11	of	of	IN
cord-015021-pol2qm74	1644	12	protective	protective	JJ
cord-015021-pol2qm74	1644	13	effect	effect	NN
cord-015021-pol2qm74	1644	14	of	of	IN
cord-015021-pol2qm74	1644	15	new	new	JJ
cord-015021-pol2qm74	1644	16	immunomodulators	immunomodulator	NNS
cord-015021-pol2qm74	1644	17	yeast	yeast	NN
cord-015021-pol2qm74	1644	18	polysaccharides	polysaccharide	NNS
cord-015021-pol2qm74	1644	19	-heteropolysaccharide	-heteropolysaccharide	.
cord-015021-pol2qm74	1645	1	Cryelan	Cryelan	NNP
cord-015021-pol2qm74	1645	2	and	and	CC
cord-015021-pol2qm74	1645	3	homopolysaccharide	homopolysaccharide	NNP
cord-015021-pol2qm74	1645	4	mannan	mannan	NNP
cord-015021-pol2qm74	1645	5	Rhodexman	Rhodexman	NNP
cord-015021-pol2qm74	1645	6	(	(	-LRB-
cord-015021-pol2qm74	1645	7	both	both	DT
cord-015021-pol2qm74	1645	8	produced	produce	VBN
cord-015021-pol2qm74	1645	9	by	by	IN
cord-015021-pol2qm74	1645	10	Petersburg	Petersburg	NNP
cord-015021-pol2qm74	1645	11	Chem.-Pharm	Chem.-Pharm	NNP
cord-015021-pol2qm74	1645	12	.	.	.
cord-015021-pol2qm74	1646	1	Inst	Inst	NNP
cord-015021-pol2qm74	1646	2	.	.	.
cord-015021-pol2qm74	1646	3	)	)	-RRB-
cord-015021-pol2qm74	1646	4	was	be	VBD
cord-015021-pol2qm74	1646	5	studied	study	VBN
cord-015021-pol2qm74	1646	6	.	.	.
cord-015021-pol2qm74	1647	1	In	in	IN
cord-015021-pol2qm74	1647	2	vitro	vitro	FW
cord-015021-pol2qm74	1647	3	according	accord	VBG
cord-015021-pol2qm74	1647	4	to	to	IN
cord-015021-pol2qm74	1647	5	NST	NST	NNP
cord-015021-pol2qm74	1647	6	test	test	NN
cord-015021-pol2qm74	1647	7	incubation	incubation	NN
cord-015021-pol2qm74	1647	8	of	of	IN
cord-015021-pol2qm74	1647	9	murine	murine	JJ
cord-015021-pol2qm74	1647	10	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	1647	11	Mphs	Mphs	NNP
cord-015021-pol2qm74	1647	12	with	with	IN
cord-015021-pol2qm74	1647	13	Cryelan	Cryelan	NNP
cord-015021-pol2qm74	1647	14	or	or	CC
cord-015021-pol2qm74	1647	15	Rhodexman	Rhodexman	NNP
cord-015021-pol2qm74	1647	16	,	,	,
cord-015021-pol2qm74	1647	17	150	150	CD
cord-015021-pol2qm74	1647	18	~g	~g	NNP
cord-015021-pol2qm74	1647	19	/	/	SYM
cord-015021-pol2qm74	1647	20	ml,30	ml,30	NNP
cord-015021-pol2qm74	1647	21	min	min	NNP
cord-015021-pol2qm74	1647	22	was	be	VBD
cord-015021-pol2qm74	1647	23	followed	follow	VBN
cord-015021-pol2qm74	1647	24	by	by	IN
cord-015021-pol2qm74	1647	25	increase	increase	NN
cord-015021-pol2qm74	1647	26	of	of	IN
cord-015021-pol2qm74	1647	27	potencial	potencial	JJ
cord-015021-pol2qm74	1647	28	microbicidic	microbicidic	NN
cord-015021-pol2qm74	1647	29	activity	activity	NN
cord-015021-pol2qm74	1647	30	of	of	IN
cord-015021-pol2qm74	1647	31	Mphs	Mphs	NNP
cord-015021-pol2qm74	1647	32	.	.	.
cord-015021-pol2qm74	1648	1	In	in	IN
cord-015021-pol2qm74	1648	2	vivo	vivo	NN
cord-015021-pol2qm74	1648	3	Mph	mph	NN
cord-015021-pol2qm74	1648	4	stimulation	stimulation	NN
cord-015021-pol2qm74	1648	5	by	by	IN
cord-015021-pol2qm74	1648	6	immunomodulators	immunomodulator	NNS
cord-015021-pol2qm74	1648	7	studied	study	VBD
cord-015021-pol2qm74	1648	8	included	include	VBN
cord-015021-pol2qm74	1648	9	increase	increase	NN
cord-015021-pol2qm74	1648	10	rate	rate	NN
cord-015021-pol2qm74	1648	11	of	of	IN
cord-015021-pol2qm74	1648	12	carbon	carbon	NN
cord-015021-pol2qm74	1648	13	particles	particle	NNS
cord-015021-pol2qm74	1648	14	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	1648	15	during	during	IN
cord-015021-pol2qm74	1648	16	single	single	JJ
cord-015021-pol2qm74	1648	17	i.v	i.v	NNP
cord-015021-pol2qm74	1648	18	.	.	NNP
cord-015021-pol2qm74	1648	19	or	or	CC
cord-015021-pol2qm74	1648	20	i.p	i.p	NNP
cord-015021-pol2qm74	1648	21	.	.	NNP
cord-015021-pol2qm74	1648	22	mode	mode	NNP
cord-015021-pol2qm74	1648	23	of	of	IN
cord-015021-pol2qm74	1648	24	administration	administration	NN
cord-015021-pol2qm74	1648	25	to	to	IN
cord-015021-pol2qm74	1648	26	mice	mouse	NNS
cord-015021-pol2qm74	1648	27	1	1	CD
cord-015021-pol2qm74	1648	28	-	-	SYM
cord-015021-pol2qm74	1648	29	14	14	CD
cord-015021-pol2qm74	1648	30	days	day	NNS
cord-015021-pol2qm74	1648	31	after	after	IN
cord-015021-pol2qm74	1648	32	(	(	-LRB-
cord-015021-pol2qm74	1648	33	peak	peak	NN
cord-015021-pol2qm74	1648	34	at	at	IN
cord-015021-pol2qm74	1648	35	2nd	2nd	JJ
cord-015021-pol2qm74	1648	36	day	day	NN
cord-015021-pol2qm74	1648	37	for	for	IN
cord-015021-pol2qm74	1648	38	i.v	i.v	NNP
cord-015021-pol2qm74	1648	39	.	.	.
cord-015021-pol2qm74	1649	1	and	and	CC
cord-015021-pol2qm74	1649	2	5th	5th	JJ
cord-015021-pol2qm74	1649	3	day	day	NN
cord-015021-pol2qm74	1649	4	for	for	IN
cord-015021-pol2qm74	1649	5	i.p	i.p	NNP
cord-015021-pol2qm74	1649	6	.	.	NNP
cord-015021-pol2qm74	1649	7	mode	mode	NNP
cord-015021-pol2qm74	1649	8	of	of	IN
cord-015021-pol2qm74	1649	9	administration	administration	NN
cord-015021-pol2qm74	1649	10	of	of	IN
cord-015021-pol2qm74	1649	11	the	the	DT
cord-015021-pol2qm74	1649	12	same	same	JJ
cord-015021-pol2qm74	1649	13	dose	dose	NN
cord-015021-pol2qm74	1649	14	of	of	IN
cord-015021-pol2qm74	1649	15	5	5	CD
cord-015021-pol2qm74	1649	16	mg/100	mg/100	NNS
cord-015021-pol2qm74	1649	17	g	g	NNP
cord-015021-pol2qm74	1649	18	b.w.).The	b.w.).The	NNP
cord-015021-pol2qm74	1649	19	preliminary	preliminary	JJ
cord-015021-pol2qm74	1649	20	injection	injection	NN
cord-015021-pol2qm74	1649	21	of	of	IN
cord-015021-pol2qm74	1649	22	Cryelan	Cryelan	NNP
cord-015021-pol2qm74	1649	23	(	(	-LRB-
cord-015021-pol2qm74	1649	24	5	5	CD
cord-015021-pol2qm74	1649	25	mg/100	mg/100	NNS
cord-015021-pol2qm74	1649	26	g	g	NNP
cord-015021-pol2qm74	1649	27	,	,	,
cord-015021-pol2qm74	1649	28	24	24	CD
cord-015021-pol2qm74	1649	29	or	or	CC
cord-015021-pol2qm74	1649	30	48	48	CD
cord-015021-pol2qm74	1649	31	h	h	NN
cord-015021-pol2qm74	1649	32	before	before	IN
cord-015021-pol2qm74	1649	33	)	)	-RRB-
cord-015021-pol2qm74	1649	34	to	to	IN
cord-015021-pol2qm74	1649	35	mice	mouse	NNS
cord-015021-pol2qm74	1649	36	with	with	IN
cord-015021-pol2qm74	1649	37	acute	acute	JJ
cord-015021-pol2qm74	1649	38	cold	cold	JJ
cord-015021-pol2qm74	1649	39	stress	stress	NN
cord-015021-pol2qm74	1649	40	(	(	-LRB-
cord-015021-pol2qm74	1650	1	-10	-10	``
cord-015021-pol2qm74	1650	2	°	°	NNP
cord-015021-pol2qm74	1650	3	C	C	NNP
cord-015021-pol2qm74	1650	4	,	,	,
cord-015021-pol2qm74	1650	5	1	1	CD
cord-015021-pol2qm74	1650	6	h	h	NN
cord-015021-pol2qm74	1650	7	)	)	-RRB-
cord-015021-pol2qm74	1650	8	revealed	reveal	VBD
cord-015021-pol2qm74	1650	9	protective	protective	JJ
cord-015021-pol2qm74	1650	10	effect	effect	NN
cord-015021-pol2qm74	1650	11	restorating	restorate	VBG
cord-015021-pol2qm74	1650	12	the	the	DT
cord-015021-pol2qm74	1650	13	value	value	NN
cord-015021-pol2qm74	1650	14	of	of	IN
cord-015021-pol2qm74	1650	15	depressed	depressed	JJ
cord-015021-pol2qm74	1650	16	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	1650	17	up	up	RP
cord-015021-pol2qm74	1650	18	to	to	IN
cord-015021-pol2qm74	1650	19	the	the	DT
cord-015021-pol2qm74	1650	20	normal	normal	JJ
cord-015021-pol2qm74	1650	21	level;the	level;the	NNP
cord-015021-pol2qm74	1650	22	positive	positive	JJ
cord-015021-pol2qm74	1650	23	effect	effect	NN
cord-015021-pol2qm74	1650	24	on	on	IN
cord-015021-pol2qm74	1650	25	ultrastructure	ultrastructure	NN
cord-015021-pol2qm74	1650	26	of	of	IN
cord-015021-pol2qm74	1650	27	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	1650	28	was	be	VBD
cord-015021-pol2qm74	1650	29	noted	note	VBN
cord-015021-pol2qm74	1650	30	also	also	RB
cord-015021-pol2qm74	1650	31	.	.	.
cord-015021-pol2qm74	1651	1	There	there	EX
cord-015021-pol2qm74	1651	2	was	be	VBD
cord-015021-pol2qm74	1651	3	no	no	DT
cord-015021-pol2qm74	1651	4	changes	change	NNS
cord-015021-pol2qm74	1651	5	of	of	IN
cord-015021-pol2qm74	1651	6	plasma	plasma	NN
cord-015021-pol2qm74	1651	7	corticosterone	corticosterone	NN
cord-015021-pol2qm74	1651	8	level	level	NN
cord-015021-pol2qm74	1651	9	between	between	IN
cord-015021-pol2qm74	1651	10	group	group	NN
cord-015021-pol2qm74	1651	11	with	with	IN
cord-015021-pol2qm74	1651	12	acute	acute	JJ
cord-015021-pol2qm74	1651	13	cold	cold	JJ
cord-015021-pol2qm74	1651	14	stress	stress	NN
cord-015021-pol2qm74	1651	15	and	and	CC
cord-015021-pol2qm74	1651	16	mice	mouse	NNS
cord-015021-pol2qm74	1651	17	with	with	IN
cord-015021-pol2qm74	1651	18	Cryelan	Cryelan	NNP
cord-015021-pol2qm74	1651	19	+	+	CC
cord-015021-pol2qm74	1651	20	acute	acute	JJ
cord-015021-pol2qm74	1651	21	cold	cold	JJ
cord-015021-pol2qm74	1651	22	stress	stress	NN
cord-015021-pol2qm74	1651	23	(	(	-LRB-
cord-015021-pol2qm74	1651	24	several	several	JJ
cord-015021-pol2qm74	1651	25	fold	fold	JJ
cord-015021-pol2qm74	1651	26	increase	increase	NN
cord-015021-pol2qm74	1651	27	comparatively	comparatively	RB
cord-015021-pol2qm74	1651	28	to	to	IN
cord-015021-pol2qm74	1651	29	the	the	DT
cord-015021-pol2qm74	1651	30	control	control	NN
cord-015021-pol2qm74	1651	31	mice).As	mice).As	NNP
cord-015021-pol2qm74	1651	32	was	be	VBD
cord-015021-pol2qm74	1651	33	suggested	suggest	VBN
cord-015021-pol2qm74	1651	34	,	,	,
cord-015021-pol2qm74	1651	35	the	the	DT
cord-015021-pol2qm74	1651	36	mechanism	mechanism	NN
cord-015021-pol2qm74	1651	37	of	of	IN
cord-015021-pol2qm74	1651	38	protection	protection	NN
cord-015021-pol2qm74	1651	39	can	can	MD
cord-015021-pol2qm74	1651	40	include	include	VB
cord-015021-pol2qm74	1651	41	Mph	mph	NN
cord-015021-pol2qm74	1651	42	stimulation	stimulation	NN
cord-015021-pol2qm74	1651	43	and	and	CC
cord-015021-pol2qm74	1651	44	secretion	secretion	NN
cord-015021-pol2qm74	1651	45	of	of	IN
cord-015021-pol2qm74	1651	46	some	some	DT
cord-015021-pol2qm74	1651	47	acute	acute	JJ
cord-015021-pol2qm74	1651	48	phase	phase	NN
cord-015021-pol2qm74	1651	49	proteins	protein	NNS
cord-015021-pol2qm74	1651	50	responsible	responsible	JJ
cord-015021-pol2qm74	1651	51	for	for	IN
cord-015021-pol2qm74	1651	52	positive	positive	JJ
cord-015021-pol2qm74	1651	53	effect	effect	NN
cord-015021-pol2qm74	1651	54	of	of	IN
cord-015021-pol2qm74	1651	55	immunomodulators	immunomodulator	NNS
cord-015021-pol2qm74	1651	56	.	.	.
cord-015021-pol2qm74	1652	1	New	new	JJ
cord-015021-pol2qm74	1652	2	yeast	yeast	NN
cord-015021-pol2qm74	1652	3	polysaccharides	polysaccharide	NNS
cord-015021-pol2qm74	1653	1	Cryelan	Cryelan	NNP
cord-015021-pol2qm74	1653	2	and	and	CC
cord-015021-pol2qm74	1653	3	Rhodexman	Rhodexman	NNP
cord-015021-pol2qm74	1653	4	can	can	MD
cord-015021-pol2qm74	1653	5	be	be	VB
cord-015021-pol2qm74	1653	6	used	use	VBN
cord-015021-pol2qm74	1653	7	for	for	IN
cord-015021-pol2qm74	1653	8	macrophage	macrophage	NN
cord-015021-pol2qm74	1653	9	stimulation	stimulation	NN
cord-015021-pol2qm74	1653	10	,	,	,
cord-015021-pol2qm74	1653	11	especially	especially	RB
cord-015021-pol2qm74	1653	12	in	in	IN
cord-015021-pol2qm74	1653	13	pathological	pathological	JJ
cord-015021-pol2qm74	1653	14	states	state	NNS
cord-015021-pol2qm74	1653	15	.	.	.
cord-015021-pol2qm74	1654	1	Immunomodulators	immunomodulator	NNS
cord-015021-pol2qm74	1654	2	were	be	VBD
cord-015021-pol2qm74	1654	3	shown	show	VBN
cord-015021-pol2qm74	1654	4	to	to	TO
cord-015021-pol2qm74	1654	5	increase	increase	VB
cord-015021-pol2qm74	1654	6	production	production	NN
cord-015021-pol2qm74	1654	7	and	and	CC
cord-015021-pol2qm74	1654	8	secretion	secretion	NN
cord-015021-pol2qm74	1654	9	of	of	IN
cord-015021-pol2qm74	1654	10	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	1654	11	enzymes	enzyme	NNS
cord-015021-pol2qm74	1654	12	(	(	-LRB-
cord-015021-pol2qm74	1654	13	like	like	IN
cord-015021-pol2qm74	1654	14	zymosan	zymosan	NNP
cord-015021-pol2qm74	1654	15	)	)	-RRB-
cord-015021-pol2qm74	1654	16	.	.	.
cord-015021-pol2qm74	1655	1	Secreted	secrete	VBN
cord-015021-pol2qm74	1655	2	enzymes	enzyme	NNS
cord-015021-pol2qm74	1655	3	,	,	,
cord-015021-pol2qm74	1655	4	especially	especially	RB
cord-015021-pol2qm74	1655	5	cysteine	cysteine	NN
cord-015021-pol2qm74	1655	6	proteinasescathepsins	proteinasescathepsin	NNS
cord-015021-pol2qm74	1655	7	B	B	NNP
cord-015021-pol2qm74	1655	8	and	and	CC
cord-015021-pol2qm74	1655	9	L	L	NNP
cord-015021-pol2qm74	1655	10	-involve	-involve	NNP
cord-015021-pol2qm74	1656	1	in	in	IN
cord-015021-pol2qm74	1656	2	the	the	DT
cord-015021-pol2qm74	1656	3	process	process	NN
cord-015021-pol2qm74	1656	4	of	of	IN
cord-015021-pol2qm74	1656	5	inflammation;however	inflammation;however	NNP
cord-015021-pol2qm74	1656	6	,	,	,
cord-015021-pol2qm74	1656	7	excessive	excessive	JJ
cord-015021-pol2qm74	1656	8	release	release	NN
cord-015021-pol2qm74	1656	9	of	of	IN
cord-015021-pol2qm74	1656	10	these	these	DT
cord-015021-pol2qm74	1656	11	enzymes	enzyme	NNS
cord-015021-pol2qm74	1656	12	may	may	MD
cord-015021-pol2qm74	1656	13	lead	lead	VB
cord-015021-pol2qm74	1656	14	to	to	IN
cord-015021-pol2qm74	1656	15	noncontrolled	noncontrolled	JJ
cord-015021-pol2qm74	1656	16	proteolysis	proteolysis	NN
cord-015021-pol2qm74	1656	17	followed	follow	VBN
cord-015021-pol2qm74	1656	18	by	by	IN
cord-015021-pol2qm74	1656	19	tissue	tissue	NN
cord-015021-pol2qm74	1656	20	degradation	degradation	NN
cord-015021-pol2qm74	1657	1	(	(	-LRB-
cord-015021-pol2qm74	1657	2	Assfalg	Assfalg	NNP
cord-015021-pol2qm74	1657	3	-	-	HYPH
cord-015021-pol2qm74	1657	4	Machleidt	Machleidt	NNP
cord-015021-pol2qm74	1657	5	et	et	NNP
cord-015021-pol2qm74	1657	6	al	al	NNP
cord-015021-pol2qm74	1657	7	.	.	NNP
cord-015021-pol2qm74	1657	8	,1990	,1990	,
cord-015021-pol2qm74	1657	9	)	)	-RRB-
cord-015021-pol2qm74	1658	1	.The	.The	.
cord-015021-pol2qm74	1659	1	effect	effect	NN
cord-015021-pol2qm74	1659	2	of	of	IN
cord-015021-pol2qm74	1659	3	zymosan	zymosan	NNP
cord-015021-pol2qm74	1659	4	,	,	,
cord-015021-pol2qm74	1659	5	BCG	BCG	NNP
cord-015021-pol2qm74	1659	6	and	and	CC
cord-015021-pol2qm74	1659	7	new	new	JJ
cord-015021-pol2qm74	1659	8	immunomodulator	immunomodulator	NNP
cord-015021-pol2qm74	1659	9	carboxymethylglucan	carboxymethylglucan	NNP
cord-015021-pol2qm74	1659	10	(	(	-LRB-
cord-015021-pol2qm74	1659	11	CMG	CMG	NNP
cord-015021-pol2qm74	1659	12	)	)	-RRB-
cord-015021-pol2qm74	1659	13	,	,	,
cord-015021-pol2qm74	1659	14	second	second	JJ
cord-015021-pol2qm74	1659	15	fraction	fraction	NN
cord-015021-pol2qm74	1659	16	on	on	IN
cord-015021-pol2qm74	1659	17	secretion	secretion	NN
cord-015021-pol2qm74	1659	18	of	of	IN
cord-015021-pol2qm74	1659	19	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	1659	20	enzymes	enzyme	NNS
cord-015021-pol2qm74	1659	21	by	by	IN
cord-015021-pol2qm74	1659	22	murine	murine	JJ
cord-015021-pol2qm74	1659	23	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	1659	24	macrophages	macrophage	NNS
cord-015021-pol2qm74	1659	25	was	be	VBD
cord-015021-pol2qm74	1659	26	studied	study	VBN
cord-015021-pol2qm74	1659	27	.	.	.
cord-015021-pol2qm74	1660	1	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	1660	2	increased	increase	VBD
cord-015021-pol2qm74	1660	3	the	the	DT
cord-015021-pol2qm74	1660	4	secretion	secretion	NN
cord-015021-pol2qm74	1660	5	of	of	IN
cord-015021-pol2qm74	1660	6	N	n	CD
cord-015021-pol2qm74	1660	7	-	-	HYPH
cord-015021-pol2qm74	1660	8	acetyl-~-D	acetyl-~-D	NNP
cord-015021-pol2qm74	1660	9	-	-	HYPH
cord-015021-pol2qm74	1660	10	glucosaminidase	glucosaminidase	NN
cord-015021-pol2qm74	1660	11	and	and	CC
cord-015021-pol2qm74	1660	12	~-galactosidase	~-galactosidase	NFP
cord-015021-pol2qm74	1660	13	into	into	IN
cord-015021-pol2qm74	1660	14	the	the	DT
cord-015021-pol2qm74	1660	15	culture	culture	NN
cord-015021-pol2qm74	1660	16	medium	medium	NN
cord-015021-pol2qm74	1660	17	(	(	-LRB-
cord-015021-pol2qm74	1660	18	3	3	CD
cord-015021-pol2qm74	1660	19	-	-	SYM
cord-015021-pol2qm74	1660	20	4	4	CD
cord-015021-pol2qm74	1660	21	fold	fold	NN
cord-015021-pol2qm74	1660	22	)	)	-RRB-
cord-015021-pol2qm74	1660	23	;	;	:
cord-015021-pol2qm74	1660	24	BCG	BCG	NNP
cord-015021-pol2qm74	1660	25	possessed	possess	VBD
cord-015021-pol2qm74	1660	26	similar	similar	JJ
cord-015021-pol2qm74	1660	27	effect	effect	NN
cord-015021-pol2qm74	1660	28	.	.	.
cord-015021-pol2qm74	1661	1	CMG	CMG	NNP
cord-015021-pol2qm74	1661	2	in	in	IN
cord-015021-pol2qm74	1661	3	the	the	DT
cord-015021-pol2qm74	1661	4	same	same	JJ
cord-015021-pol2qm74	1661	5	concentrations	concentration	NNS
cord-015021-pol2qm74	1661	6	(	(	-LRB-
cord-015021-pol2qm74	1661	7	50	50	CD
cord-015021-pol2qm74	1661	8	/~g	/~g	,
cord-015021-pol2qm74	1661	9	/	/	SYM
cord-015021-pol2qm74	1661	10	ml	ml	NN
cord-015021-pol2qm74	1661	11	)	)	-RRB-
cord-015021-pol2qm74	1661	12	increased	increase	VBN
cord-015021-pol2qm74	1661	13	release	release	NN
cord-015021-pol2qm74	1661	14	of	of	IN
cord-015021-pol2qm74	1661	15	these	these	DT
cord-015021-pol2qm74	1661	16	enzymes	enzyme	NNS
cord-015021-pol2qm74	1662	1	only	only	RB
cord-015021-pol2qm74	1662	2	sAightly	sAightly	NNP
cord-015021-pol2qm74	1662	3	(	(	-LRB-
cord-015021-pol2qm74	1662	4	1.6	1.6	CD
cord-015021-pol2qm74	1662	5	times).It	times).it	NN
cord-015021-pol2qm74	1662	6	's	be	VBZ
cord-015021-pol2qm74	1662	7	known	know	VBN
cord-015021-pol2qm74	1662	8	that	that	IN
cord-015021-pol2qm74	1662	9	zymosan	zymosan	NN
cord-015021-pol2qm74	1662	10	-	-	HYPH
cord-015021-pol2qm74	1662	11	induced	induce	VBN
cord-015021-pol2qm74	1662	12	secretion	secretion	NN
cord-015021-pol2qm74	1662	13	reflects	reflect	VBZ
cord-015021-pol2qm74	1662	14	the	the	DT
cord-015021-pol2qm74	1662	15	enzyme	enzyme	NN
cord-015021-pol2qm74	1662	16	release	release	NN
cord-015021-pol2qm74	1662	17	from	from	IN
cord-015021-pol2qm74	1662	18	formed	form	VBN
cord-015021-pol2qm74	1662	19	lysosomes	lysosome	NNS
cord-015021-pol2qm74	1662	20	(	(	-LRB-
cord-015021-pol2qm74	1662	21	Warren,1989	Warren,1989	NNP
cord-015021-pol2qm74	1662	22	)	)	-RRB-
cord-015021-pol2qm74	1662	23	.It	.It	.
cord-015021-pol2qm74	1663	1	was	be	VBD
cord-015021-pol2qm74	1663	2	suggested	suggest	VBN
cord-015021-pol2qm74	1663	3	that	that	IN
cord-015021-pol2qm74	1663	4	CMG	CMG	NNP
cord-015021-pol2qm74	1663	5	activated	activate	VBD
cord-015021-pol2qm74	1663	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	1663	7	via	via	IN
cord-015021-pol2qm74	1663	8	interaction	interaction	NN
cord-015021-pol2qm74	1663	9	with	with	IN
cord-015021-pol2qm74	1663	10	scavenger	scavenger	NN
cord-015021-pol2qm74	1663	11	-	-	HYPH
cord-015021-pol2qm74	1663	12	receptors	receptor	NNS
cord-015021-pol2qm74	1663	13	,	,	,
cord-015021-pol2qm74	1663	14	followed	follow	VBN
cord-015021-pol2qm74	1663	15	by	by	IN
cord-015021-pol2qm74	1663	16	weak	weak	JJ
cord-015021-pol2qm74	1663	17	secretion	secretion	NN
cord-015021-pol2qm74	1663	18	of	of	IN
cord-015021-pol2qm74	1663	19	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	1663	20	enzymes	enzyme	NNS
cord-015021-pol2qm74	1663	21	and	and	CC
cord-015021-pol2qm74	1663	22	as	as	IN
cord-015021-pol2qm74	1663	23	a	a	DT
cord-015021-pol2qm74	1663	24	result	result	NN
cord-015021-pol2qm74	1663	25	decrease	decrease	NN
cord-015021-pol2qm74	1663	26	of	of	IN
cord-015021-pol2qm74	1663	27	tissue	tissue	NN
cord-015021-pol2qm74	1663	28	damage	damage	NN
cord-015021-pol2qm74	1663	29	.	.	.
cord-015021-pol2qm74	1664	1	In	in	IN
cord-015021-pol2qm74	1664	2	vivo	vivo	NNP
cord-015021-pol2qm74	1664	3	zymosan	zymosan	NNP
cord-015021-pol2qm74	1664	4	induced	induce	VBD
cord-015021-pol2qm74	1664	5	stimulation	stimulation	NN
cord-015021-pol2qm74	1664	6	of	of	IN
cord-015021-pol2qm74	1664	7	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	1664	8	system	system	NN
cord-015021-pol2qm74	1664	9	of	of	IN
cord-015021-pol2qm74	1664	10	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	1664	11	followed	follow	VBN
cord-015021-pol2qm74	1664	12	by	by	IN
cord-015021-pol2qm74	1664	13	increase	increase	NN
cord-015021-pol2qm74	1664	14	of	of	IN
cord-015021-pol2qm74	1664	15	cysteine	cysteine	NN
cord-015021-pol2qm74	1664	16	proteinases	proteinases	NNP
cord-015021-pol2qm74	1664	17	activity	activity	NN
cord-015021-pol2qm74	1664	18	in	in	IN
cord-015021-pol2qm74	1664	19	liver	liver	NN
cord-015021-pol2qm74	1664	20	at	at	IN
cord-015021-pol2qm74	1664	21	the	the	DT
cord-015021-pol2qm74	1664	22	5th	5th	JJ
cord-015021-pol2qm74	1664	23	day	day	NN
cord-015021-pol2qm74	1664	24	.	.	.
cord-015021-pol2qm74	1665	1	In	in	IN
cord-015021-pol2qm74	1665	2	the	the	DT
cord-015021-pol2qm74	1665	3	same	same	JJ
cord-015021-pol2qm74	1665	4	time	time	NN
cord-015021-pol2qm74	1665	5	in	in	IN
cord-015021-pol2qm74	1665	6	blood	blood	NN
cord-015021-pol2qm74	1665	7	N	n	CD
cord-015021-pol2qm74	1665	8	-	-	HYPH
cord-015021-pol2qm74	1665	9	acetyl-~-D	acetyl-~-D	NNP
cord-015021-pol2qm74	1665	10	-	-	HYPH
cord-015021-pol2qm74	1665	11	glucosaminidase	glucosaminidase	NN
cord-015021-pol2qm74	1665	12	and	and	CC
cord-015021-pol2qm74	1665	13	N	N	NNP
cord-015021-pol2qm74	1665	14	-	-	HYPH
cord-015021-pol2qm74	1665	15	acetyl-~-D	acetyl-~-d	NN
cord-015021-pol2qm74	1665	16	-	-	HYPH
cord-015021-pol2qm74	1665	17	galactosidase	galactosidase	NN
cord-015021-pol2qm74	1665	18	activity	activity	NN
cord-015021-pol2qm74	1665	19	increased	increase	VBD
cord-015021-pol2qm74	1665	20	2	2	CD
cord-015021-pol2qm74	1665	21	-	-	SYM
cord-015021-pol2qm74	1665	22	5	5	CD
cord-015021-pol2qm74	1665	23	fold	fold	NN
cord-015021-pol2qm74	1665	24	.	.	.
cord-015021-pol2qm74	1666	1	It	-PRON-	PRP
cord-015021-pol2qm74	1666	2	was	be	VBD
cord-015021-pol2qm74	1666	3	concluded	conclude	VBN
cord-015021-pol2qm74	1666	4	that	that	IN
cord-015021-pol2qm74	1666	5	in	in	IN
cord-015021-pol2qm74	1666	6	drug	drug	NN
cord-015021-pol2qm74	1666	7	design	design	NN
cord-015021-pol2qm74	1666	8	it	-PRON-	PRP
cord-015021-pol2qm74	1666	9	's	be	VBZ
cord-015021-pol2qm74	1666	10	possible	possible	JJ
cord-015021-pol2qm74	1666	11	to	to	TO
cord-015021-pol2qm74	1666	12	select	select	VB
cord-015021-pol2qm74	1666	13	such	such	JJ
cord-015021-pol2qm74	1666	14	immunomodulators	immunomodulator	NNS
cord-015021-pol2qm74	1666	15	,	,	,
cord-015021-pol2qm74	1666	16	e.g	e.g	NNP
cord-015021-pol2qm74	1666	17	.	.	NNP
cord-015021-pol2qm74	1666	18	CMG	CMG	NNP
cord-015021-pol2qm74	1666	19	,	,	,
cord-015021-pol2qm74	1666	20	which	which	WDT
cord-015021-pol2qm74	1666	21	can	can	MD
cord-015021-pol2qm74	1666	22	activate	activate	VB
cord-015021-pol2qm74	1666	23	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	1666	24	system	system	NN
cord-015021-pol2qm74	1666	25	of	of	IN
cord-015021-pol2qm74	1666	26	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	1666	27	and	and	CC
cord-015021-pol2qm74	1666	28	do	do	VBP
cord-015021-pol2qm74	1666	29	not	not	RB
cord-015021-pol2qm74	1666	30	damage	damage	VB
cord-015021-pol2qm74	1666	31	tissue	tissue	NN
cord-015021-pol2qm74	1666	32	.	.	.
cord-015021-pol2qm74	1667	1	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	1667	2	-	-	HYPH
cord-015021-pol2qm74	1667	3	i	i	NNP
cord-015021-pol2qm74	1667	4	(	(	-LRB-
cord-015021-pol2qm74	1667	5	ET	et	NN
cord-015021-pol2qm74	1667	6	-	-	HYPH
cord-015021-pol2qm74	1667	7	I	I	NNP
cord-015021-pol2qm74	1667	8	)	)	-RRB-
cord-015021-pol2qm74	1667	9	is	be	VBZ
cord-015021-pol2qm74	1667	10	produced	produce	VBN
cord-015021-pol2qm74	1667	11	by	by	IN
cord-015021-pol2qm74	1667	12	injured/	injured/	NN
cord-015021-pol2qm74	1667	13	ischemic	ischemic	JJ
cord-015021-pol2qm74	1667	14	endothelium	endothelium	NN
cord-015021-pol2qm74	1667	15	,	,	,
cord-015021-pol2qm74	1667	16	mobilizes	mobilize	VBZ
cord-015021-pol2qm74	1667	17	intracellular	intracellular	JJ
cord-015021-pol2qm74	1667	18	Ca	Ca	NNP
cord-015021-pol2qm74	1667	19	+	+	CC
cord-015021-pol2qm74	1668	1	+	+	CC
cord-015021-pol2qm74	1668	2	and	and	CC
cord-015021-pol2qm74	1668	3	is	be	VBZ
cord-015021-pol2qm74	1668	4	a	a	DT
cord-015021-pol2qm74	1668	5	potent	potent	JJ
cord-015021-pol2qm74	1668	6	vasoconstrictor	vasoconstrictor	NN
cord-015021-pol2qm74	1668	7	.	.	.
cord-015021-pol2qm74	1669	1	It	-PRON-	PRP
cord-015021-pol2qm74	1669	2	is	be	VBZ
cord-015021-pol2qm74	1669	3	also	also	RB
cord-015021-pol2qm74	1669	4	a	a	DT
cord-015021-pol2qm74	1669	5	Ca	Ca	NNP
cord-015021-pol2qm74	1669	6	+	+	CC
cord-015021-pol2qm74	1669	7	+	+	CC
cord-015021-pol2qm74	1669	8	agonist	agonist	NN
cord-015021-pol2qm74	1669	9	for	for	IN
cord-015021-pol2qm74	1669	10	anterior	anterior	JJ
cord-015021-pol2qm74	1669	11	pituitary	pituitary	NN
cord-015021-pol2qm74	1669	12	or	or	CC
cord-015021-pol2qm74	1669	13	renal	renal	JJ
cord-015021-pol2qm74	1669	14	mesangial	mesangial	JJ
cord-015021-pol2qm74	1669	15	cells	cell	NNS
cord-015021-pol2qm74	1669	16	and	and	CC
cord-015021-pol2qm74	1669	17	monocytes	monocyte	NNS
cord-015021-pol2qm74	1669	18	.	.	.
cord-015021-pol2qm74	1670	1	ET	ET	NNP
cord-015021-pol2qm74	1670	2	-	-	HYPH
cord-015021-pol2qm74	1670	3	I	-PRON-	PRP
cord-015021-pol2qm74	1670	4	causes	cause	VBZ
cord-015021-pol2qm74	1670	5	monocytes	monocyte	NNS
cord-015021-pol2qm74	1670	6	to	to	TO
cord-015021-pol2qm74	1670	7	produce	produce	VB
cord-015021-pol2qm74	1670	8	interleukin	interleukin	NN
cord-015021-pol2qm74	1670	9	-	-	HYPH
cord-015021-pol2qm74	1670	10	l	l	NN
cord-015021-pol2qm74	1670	11	,	,	,
cord-015021-pol2qm74	1670	12	6	6	CD
cord-015021-pol2qm74	1670	13	,	,	,
cord-015021-pol2qm74	1670	14	8	8	CD
cord-015021-pol2qm74	1670	15	,	,	,
cord-015021-pol2qm74	1670	16	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	1670	17	E2	e2	NN
cord-015021-pol2qm74	1670	18	,	,	,
cord-015021-pol2qm74	1670	19	and	and	CC
cord-015021-pol2qm74	1670	20	substances	substance	NNS
cord-015021-pol2qm74	1670	21	which	which	WDT
cord-015021-pol2qm74	1670	22	trigger	trigger	VBP
cord-015021-pol2qm74	1670	23	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1670	24	superoxide	superoxide	NN
cord-015021-pol2qm74	1670	25	production	production	NN
cord-015021-pol2qm74	1670	26	.	.	.
cord-015021-pol2qm74	1671	1	ET-	ET-	NNP
cord-015021-pol2qm74	1672	1	I	-PRON-	PRP
cord-015021-pol2qm74	1672	2	levels	level	NNS
cord-015021-pol2qm74	1672	3	increase	increase	VBP
cord-015021-pol2qm74	1672	4	in	in	IN
cord-015021-pol2qm74	1672	5	shock	shock	NN
cord-015021-pol2qm74	1672	6	and	and	CC
cord-015021-pol2qm74	1672	7	ET	ET	NNP
cord-015021-pol2qm74	1672	8	may	may	MD
cord-015021-pol2qm74	1672	9	play	play	VB
cord-015021-pol2qm74	1672	10	a	a	DT
cord-015021-pol2qm74	1672	11	role	role	NN
cord-015021-pol2qm74	1672	12	in	in	IN
cord-015021-pol2qm74	1672	13	activating	activate	VBG
cord-015021-pol2qm74	1672	14	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1672	15	post	post	NN
cord-015021-pol2qm74	1672	16	shock	shock	NN
cord-015021-pol2qm74	1672	17	causing	cause	VBG
cord-015021-pol2qm74	1672	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1672	19	injury	injury	NN
cord-015021-pol2qm74	1672	20	.	.	.
cord-015021-pol2qm74	1673	1	But	but	CC
cord-015021-pol2qm74	1673	2	blood	blood	NN
cord-015021-pol2qm74	1673	3	flow	flow	NN
cord-015021-pol2qm74	1673	4	experiments	experiment	NNS
cord-015021-pol2qm74	1673	5	suggest	suggest	VBP
cord-015021-pol2qm74	1673	6	splanchnic	splanchnic	JJ
cord-015021-pol2qm74	1673	7	circulation	circulation	NN
cord-015021-pol2qm74	1673	8	changes	change	NNS
cord-015021-pol2qm74	1673	9	more	more	RBR
cord-015021-pol2qm74	1673	10	profoundly	profoundly	RB
cord-015021-pol2qm74	1673	11	in	in	IN
cord-015021-pol2qm74	1673	12	shock	shock	NN
cord-015021-pol2qm74	1673	13	than	than	IN
cord-015021-pol2qm74	1673	14	peripheral	peripheral	JJ
cord-015021-pol2qm74	1673	15	circulation	circulation	NN
cord-015021-pol2qm74	1673	16	.	.	.
cord-015021-pol2qm74	1674	1	We	-PRON-	PRP
cord-015021-pol2qm74	1674	2	therefore	therefore	RB
cord-015021-pol2qm74	1674	3	asked	ask	VBD
cord-015021-pol2qm74	1674	4	if	if	IN
cord-015021-pol2qm74	1674	5	ET-4	ET-4	NNP
cord-015021-pol2qm74	1674	6	(	(	-LRB-
cord-015021-pol2qm74	1674	7	or	or	CC
cord-015021-pol2qm74	1674	8	VIC	VIC	NNP
cord-015021-pol2qm74	1674	9	)	)	-RRB-
cord-015021-pol2qm74	1674	10	,	,	,
cord-015021-pol2qm74	1674	11	the	the	DT
cord-015021-pol2qm74	1674	12	ET	ET	NNP
cord-015021-pol2qm74	1674	13	which	which	WDT
cord-015021-pol2qm74	1674	14	predominates	predominate	VBZ
cord-015021-pol2qm74	1674	15	in	in	IN
cord-015021-pol2qm74	1674	16	splanchnic	splanchnic	JJ
cord-015021-pol2qm74	1674	17	vessels	vessel	NNS
cord-015021-pol2qm74	1674	18	,	,	,
cord-015021-pol2qm74	1674	19	had	have	VBD
cord-015021-pol2qm74	1674	20	any	any	DT
cord-015021-pol2qm74	1674	21	effect	effect	NN
cord-015021-pol2qm74	1674	22	on	on	IN
cord-015021-pol2qm74	1674	23	monocyte	monocyte	NNP
cord-015021-pol2qm74	1674	24	cytokine	cytokine	NN
cord-015021-pol2qm74	1674	25	production	production	NN
cord-015021-pol2qm74	1674	26	.	.	.
cord-015021-pol2qm74	1675	1	Human	human	JJ
cord-015021-pol2qm74	1675	2	monocytes	monocyte	NNS
cord-015021-pol2qm74	1675	3	from	from	IN
cord-015021-pol2qm74	1675	4	health~	health~	NNP
cord-015021-pol2qm74	1675	5	blood	blood	NN
cord-015021-pol2qm74	1675	6	donors	donor	NNS
cord-015021-pol2qm74	1675	7	were	be	VBD
cord-015021-pol2qm74	1675	8	separated	separate	VBN
cord-015021-pol2qm74	1675	9	on	on	IN
cord-015021-pol2qm74	1675	10	Ficoll	Ficoll	NNP
cord-015021-pol2qm74	1675	11	.	.	.
cord-015021-pol2qm74	1676	1	0.5	0.5	CD
cord-015021-pol2qm74	1676	2	x	x	SYM
cord-015021-pol2qm74	1676	3	10Ucells/	10ucells/	CD
cord-015021-pol2qm74	1676	4	ml	ml	NNS
cord-015021-pol2qm74	1676	5	in	in	IN
cord-015021-pol2qm74	1676	6	RPMI	RPMI	NNP
cord-015021-pol2qm74	1677	1	1640	1640	CD
cord-015021-pol2qm74	1678	1	+	+	CC
cord-015021-pol2qm74	1679	1	10	10	CD
cord-015021-pol2qm74	1679	2	%	%	NN
cord-015021-pol2qm74	1679	3	FCS	FCS	NNP
cord-015021-pol2qm74	1679	4	were	be	VBD
cord-015021-pol2qm74	1679	5	incubated	incubate	VBN
cord-015021-pol2qm74	1679	6	i0	i0	NNP
cord-015021-pol2qm74	1679	7	min	min	NNP
cord-015021-pol2qm74	1679	8	.	.	.
cord-015021-pol2qm74	1680	1	,	,	,
cord-015021-pol2qm74	1680	2	6	6	CD
cord-015021-pol2qm74	1680	3	&	&	CC
cord-015021-pol2qm74	1680	4	24	24	CD
cord-015021-pol2qm74	1680	5	hrs	hrs	NN
cord-015021-pol2qm74	1680	6	.	.	.
cord-015021-pol2qm74	1681	1	with	with	IN
cord-015021-pol2qm74	1681	2	10	10	CD
cord-015021-pol2qm74	1681	3	-8	-8	NNP
cord-015021-pol2qm74	1681	4	M	M	NNP
cord-015021-pol2qm74	1681	5	ET	et	NN
cord-015021-pol2qm74	1681	6	-	-	HYPH
cord-015021-pol2qm74	1681	7	I	I	NNP
cord-015021-pol2qm74	1681	8	,	,	,
cord-015021-pol2qm74	1681	9	10	10	CD
cord-015021-pol2qm74	1681	10	-8	-8	NNP
cord-015021-pol2qm74	1681	11	M	M	NNP
cord-015021-pol2qm74	1681	12	VIC	VIC	NNP
cord-015021-pol2qm74	1681	13	or	or	CC
cord-015021-pol2qm74	1681	14	I0	I0	NNP
cord-015021-pol2qm74	1681	15	ug	ug	NNP
cord-015021-pol2qm74	1681	16	/	/	SYM
cord-015021-pol2qm74	1681	17	ml	ml	NN
cord-015021-pol2qm74	1681	18	of	of	IN
cord-015021-pol2qm74	1681	19	LPS	LPS	NNP
cord-015021-pol2qm74	1681	20	.	.	.
cord-015021-pol2qm74	1682	1	Supernatants	supernatant	NNS
cord-015021-pol2qm74	1682	2	were	be	VBD
cord-015021-pol2qm74	1682	3	assayed	assay	VBN
cord-015021-pol2qm74	1682	4	by	by	IN
cord-015021-pol2qm74	1682	5	ELISA	ELISA	NNP
cord-015021-pol2qm74	1682	6	.	.	.
cord-015021-pol2qm74	1683	1	We	-PRON-	PRP
cord-015021-pol2qm74	1683	2	have	have	VBP
cord-015021-pol2qm74	1683	3	shown	show	VBN
cord-015021-pol2qm74	1683	4	that	that	IN
cord-015021-pol2qm74	1683	5	low	low	JJ
cord-015021-pol2qm74	1683	6	dose	dose	NN
cord-015021-pol2qm74	1683	7	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1683	8	pretreatment	pretreatment	NN
cord-015021-pol2qm74	1683	9	(	(	-LRB-
cord-015021-pol2qm74	1683	10	LPS	LPS	NNP
cord-015021-pol2qm74	1683	11	1	1	CD
cord-015021-pol2qm74	1683	12	)	)	-RRB-
cord-015021-pol2qm74	1683	13	for	for	IN
cord-015021-pol2qm74	1683	14	24	24	CD
cord-015021-pol2qm74	1683	15	hrs	hrs	NN
cord-015021-pol2qm74	1683	16	markedly	markedly	RB
cord-015021-pol2qm74	1683	17	inhibits	inhibit	VBZ
cord-015021-pol2qm74	1683	18	the	the	DT
cord-015021-pol2qm74	1683	19	macrophage	macrophage	NN
cord-015021-pol2qm74	1683	20	(	(	-LRB-
cord-015021-pol2qm74	1683	21	MO	MO	NNP
cord-015021-pol2qm74	1683	22	)	)	-RRB-
cord-015021-pol2qm74	1683	23	release	release	NN
cord-015021-pol2qm74	1683	24	of	of	IN
cord-015021-pol2qm74	1683	25	tumor	tumor	NN
cord-015021-pol2qm74	1683	26	necrosis	necrosis	NN
cord-015021-pol2qm74	1683	27	factor	factor	NN
cord-015021-pol2qm74	1683	28	(	(	-LRB-
cord-015021-pol2qm74	1683	29	TNF	TNF	NNP
cord-015021-pol2qm74	1683	30	)	)	-RRB-
cord-015021-pol2qm74	1683	31	and	and	CC
cord-015021-pol2qm74	1683	32	increases	increase	VBZ
cord-015021-pol2qm74	1683	33	interleukin-1	interleukin-1	NNP
cord-015021-pol2qm74	1683	34	(	(	-LRB-
cord-015021-pol2qm74	1683	35	IL	IL	NNP
cord-015021-pol2qm74	1683	36	-	-	HYPH
cord-015021-pol2qm74	1683	37	I	I	NNP
cord-015021-pol2qm74	1683	38	)	)	-RRB-
cord-015021-pol2qm74	1683	39	in	in	IN
cord-015021-pol2qm74	1683	40	response	response	NN
cord-015021-pol2qm74	1683	41	to	to	IN
cord-015021-pol2qm74	1683	42	a	a	DT
cord-015021-pol2qm74	1683	43	subsequent	subsequent	JJ
cord-015021-pol2qm74	1683	44	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1683	45	stimulus	stimulus	NN
cord-015021-pol2qm74	1683	46	(	(	-LRB-
cord-015021-pol2qm74	1683	47	LPS2	LPS2	NNP
cord-015021-pol2qm74	1683	48	)	)	-RRB-
cord-015021-pol2qm74	1683	49	.	.	.
cord-015021-pol2qm74	1684	1	In	in	IN
cord-015021-pol2qm74	1684	2	this	this	DT
cord-015021-pol2qm74	1684	3	study	study	NN
cord-015021-pol2qm74	1684	4	we	-PRON-	PRP
cord-015021-pol2qm74	1684	5	examined	examine	VBD
cord-015021-pol2qm74	1684	6	the	the	DT
cord-015021-pol2qm74	1684	7	kinetics	kinetic	NNS
cord-015021-pol2qm74	1684	8	of	of	IN
cord-015021-pol2qm74	1684	9	LPS	LPS	NNP
cord-015021-pol2qm74	1684	10	1	1	CD
cord-015021-pol2qm74	1684	11	inhibition	inhibition	NN
cord-015021-pol2qm74	1684	12	of	of	IN
cord-015021-pol2qm74	1684	13	TNF	TNF	NNP
cord-015021-pol2qm74	1684	14	and	and	CC
cord-015021-pol2qm74	1684	15	augmentation	augmentation	NN
cord-015021-pol2qm74	1684	16	ofIL-1	ofil-1	CD
cord-015021-pol2qm74	1684	17	.	.	.
cord-015021-pol2qm74	1685	1	Methods	method	NNS
cord-015021-pol2qm74	1685	2	:	:	:
cord-015021-pol2qm74	1686	1	Murine	murine	JJ
cord-015021-pol2qm74	1686	2	peritoneal	peritoneal	NN
cord-015021-pol2qm74	1686	3	exudate	exudate	NN
cord-015021-pol2qm74	1686	4	MO	MO	NNP
cord-015021-pol2qm74	1686	5	from	from	IN
cord-015021-pol2qm74	1686	6	Balbc	Balbc	NNP
cord-015021-pol2qm74	1686	7	mice	mouse	NNS
cord-015021-pol2qm74	1686	8	were	be	VBD
cord-015021-pol2qm74	1686	9	exposed	expose	VBN
cord-015021-pol2qm74	1686	10	in	in	IN
cord-015021-pol2qm74	1686	11	vitro	vitro	FW
cord-015021-pol2qm74	1686	12	to	to	IN
cord-015021-pol2qm74	1686	13	medium	medium	NN
cord-015021-pol2qm74	1686	14	or	or	CC
cord-015021-pol2qm74	1686	15	10	10	CD
cord-015021-pol2qm74	1686	16	ng	ng	NN
cord-015021-pol2qm74	1686	17	/	/	SYM
cord-015021-pol2qm74	1686	18	ml	ml	NN
cord-015021-pol2qm74	1686	19	of	of	IN
cord-015021-pol2qm74	1686	20	LPS1	LPS1	NNP
cord-015021-pol2qm74	1686	21	for	for	IN
cord-015021-pol2qm74	1686	22	intervals	interval	NNS
cord-015021-pol2qm74	1686	23	of	of	IN
cord-015021-pol2qm74	1686	24	0	0	CD
cord-015021-pol2qm74	1686	25	to	to	TO
cord-015021-pol2qm74	1686	26	24	24	CD
cord-015021-pol2qm74	1686	27	hours	hour	NNS
cord-015021-pol2qm74	1686	28	.	.	.
cord-015021-pol2qm74	1687	1	Culture	culture	NN
cord-015021-pol2qm74	1687	2	medium	medium	NN
cord-015021-pol2qm74	1687	3	was	be	VBD
cord-015021-pol2qm74	1687	4	then	then	RB
cord-015021-pol2qm74	1687	5	replaced	replace	VBN
cord-015021-pol2qm74	1687	6	with	with	IN
cord-015021-pol2qm74	1687	7	0	0	CD
cord-015021-pol2qm74	1687	8	,	,	,
cord-015021-pol2qm74	1687	9	10	10	CD
cord-015021-pol2qm74	1687	10	or	or	CC
cord-015021-pol2qm74	1687	11	1000	1000	CD
cord-015021-pol2qm74	1687	12	ng	ng	NN
cord-015021-pol2qm74	1687	13	/	/	SYM
cord-015021-pol2qm74	1687	14	ml	ml	NN
cord-015021-pol2qm74	1687	15	of	of	IN
cord-015021-pol2qm74	1687	16	LPS2	LPS2	NNP
cord-015021-pol2qm74	1687	17	for	for	IN
cord-015021-pol2qm74	1687	18	24	24	CD
cord-015021-pol2qm74	1687	19	hrs	hrs	NN
cord-015021-pol2qm74	1687	20	.	.	.
cord-015021-pol2qm74	1688	1	TNF	TNF	NNP
cord-015021-pol2qm74	1688	2	and	and	CC
cord-015021-pol2qm74	1688	3	IL-1	IL-1	NNP
cord-015021-pol2qm74	1688	4	in	in	IN
cord-015021-pol2qm74	1688	5	MO	MO	NNP
cord-015021-pol2qm74	1688	6	supernatants	supernatant	NNS
cord-015021-pol2qm74	1688	7	were	be	VBD
cord-015021-pol2qm74	1688	8	measured	measure	VBN
cord-015021-pol2qm74	1688	9	by	by	IN
cord-015021-pol2qm74	1688	10	specific	specific	JJ
cord-015021-pol2qm74	1688	11	bioassays	bioassay	NNS
cord-015021-pol2qm74	1688	12	.	.	.
cord-015021-pol2qm74	1689	1	During	during	IN
cord-015021-pol2qm74	1689	2	sepsis	sepsis	NN
cord-015021-pol2qm74	1689	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1689	4	(	(	-LRB-
cord-015021-pol2qm74	1689	5	LPS	LPS	NNP
cord-015021-pol2qm74	1689	6	)	)	-RRB-
cord-015021-pol2qm74	1689	7	activates	activate	VBZ
cord-015021-pol2qm74	1689	8	macrophages	macrophage	NNS
cord-015021-pol2qm74	1689	9	(	(	-LRB-
cord-015021-pol2qm74	1689	10	MO	MO	NNP
cord-015021-pol2qm74	1689	11	)	)	-RRB-
cord-015021-pol2qm74	1689	12	to	to	TO
cord-015021-pol2qm74	1689	13	release	release	VB
cord-015021-pol2qm74	1689	14	mediators	mediator	NNS
cord-015021-pol2qm74	1689	15	such	such	JJ
cord-015021-pol2qm74	1689	16	as	as	IN
cord-015021-pol2qm74	1689	17	tumor	tumor	NN
cord-015021-pol2qm74	1689	18	necrosis	necrosis	NN
cord-015021-pol2qm74	1689	19	factor	factor	NN
cord-015021-pol2qm74	1689	20	(	(	-LRB-
cord-015021-pol2qm74	1689	21	TNF	TNF	NNP
cord-015021-pol2qm74	1689	22	)	)	-RRB-
cord-015021-pol2qm74	1689	23	,	,	.
cord-015021-pol2qm74	1690	1	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	1690	2	(	(	-LRB-
cord-015021-pol2qm74	1690	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	1690	4	)	)	-RRB-
cord-015021-pol2qm74	1690	5	,	,	,
cord-015021-pol2qm74	1690	6	interleukin	interleukin	NN
cord-015021-pol2qm74	1690	7	-	-	:
cord-015021-pol2qm74	1690	8	I	i	NN
cord-015021-pol2qm74	1690	9	(	(	-LRB-
cord-015021-pol2qm74	1690	10	IL	IL	NNP
cord-015021-pol2qm74	1690	11	-	-	HYPH
cord-015021-pol2qm74	1690	12	I	I	NNP
cord-015021-pol2qm74	1690	13	)	)	-RRB-
cord-015021-pol2qm74	1690	14	and	and	CC
cord-015021-pol2qm74	1690	15	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	1690	16	E2	e2	NN
cord-015021-pol2qm74	1690	17	(	(	-LRB-
cord-015021-pol2qm74	1690	18	PGE2	PGE2	NNP
cord-015021-pol2qm74	1690	19	)	)	-RRB-
cord-015021-pol2qm74	1690	20	.	.	.
cord-015021-pol2qm74	1691	1	We	-PRON-	PRP
cord-015021-pol2qm74	1691	2	showed	show	VBD
cord-015021-pol2qm74	1691	3	that	that	IN
cord-015021-pol2qm74	1691	4	preexposure	preexposure	NN
cord-015021-pol2qm74	1691	5	to	to	IN
cord-015021-pol2qm74	1691	6	LPS	LPS	NNP
cord-015021-pol2qm74	1691	7	(	(	-LRB-
cord-015021-pol2qm74	1691	8	LPS	LPS	NNP
cord-015021-pol2qm74	1691	9	1	1	CD
cord-015021-pol2qm74	1691	10	)	)	-RRB-
cord-015021-pol2qm74	1691	11	alters	alter	VBZ
cord-015021-pol2qm74	1691	12	the	the	DT
cord-015021-pol2qm74	1691	13	response	response	NN
cord-015021-pol2qm74	1691	14	of	of	IN
cord-015021-pol2qm74	1691	15	murine	murine	JJ
cord-015021-pol2qm74	1691	16	M	M	NNP
cord-015021-pol2qm74	1691	17	~	~	NFP
cord-015021-pol2qm74	1691	18	i	i	NN
cord-015021-pol2qm74	1691	19	to	to	IN
cord-015021-pol2qm74	1691	20	subsequent	subsequent	JJ
cord-015021-pol2qm74	1691	21	LPS	LPS	NNP
cord-015021-pol2qm74	1691	22	stimulation	stimulation	NN
cord-015021-pol2qm74	1691	23	(	(	-LRB-
cord-015021-pol2qm74	1691	24	LPS2	LPS2	NNP
cord-015021-pol2qm74	1691	25	)	)	-RRB-
cord-015021-pol2qm74	1691	26	.	.	.
cord-015021-pol2qm74	1692	1	We	-PRON-	PRP
cord-015021-pol2qm74	1692	2	hypothesized	hypothesize	VBD
cord-015021-pol2qm74	1692	3	that	that	IN
cord-015021-pol2qm74	1692	4	in	in	IN
cord-015021-pol2qm74	1692	5	vitro	vitro	FW
cord-015021-pol2qm74	1692	6	cytokine	cytokine	NN
cord-015021-pol2qm74	1692	7	release	release	NN
cord-015021-pol2qm74	1692	8	by	by	IN
cord-015021-pol2qm74	1692	9	LPS2	LPS2	NNP
cord-015021-pol2qm74	1692	10	in	in	IN
cord-015021-pol2qm74	1692	11	human	human	JJ
cord-015021-pol2qm74	1692	12	monocytes	monocyte	NNS
cord-015021-pol2qm74	1692	13	(	(	-LRB-
cord-015021-pol2qm74	1692	14	MO	MO	NNP
cord-015021-pol2qm74	1692	15	)	)	-RRB-
cord-015021-pol2qm74	1692	16	is	be	VBZ
cord-015021-pol2qm74	1692	17	also	also	RB
cord-015021-pol2qm74	1692	18	be	be	VB
cord-015021-pol2qm74	1692	19	altered	alter	VBN
cord-015021-pol2qm74	1692	20	by	by	IN
cord-015021-pol2qm74	1692	21	preexposure	preexposure	NN
cord-015021-pol2qm74	1692	22	to	to	IN
cord-015021-pol2qm74	1692	23	LPSI	LPSI	NNP
cord-015021-pol2qm74	1692	24	.	.	.
cord-015021-pol2qm74	1693	1	Methods	method	NNS
cord-015021-pol2qm74	1693	2	:	:	:
cord-015021-pol2qm74	1694	1	Human	human	JJ
cord-015021-pol2qm74	1694	2	peripheral	peripheral	JJ
cord-015021-pol2qm74	1694	3	blood	blood	NN
cord-015021-pol2qm74	1694	4	MO	MO	NNP
cord-015021-pol2qm74	1694	5	were	be	VBD
cord-015021-pol2qm74	1694	6	obtained	obtain	VBN
cord-015021-pol2qm74	1694	7	from	from	IN
cord-015021-pol2qm74	1694	8	healthy	healthy	JJ
cord-015021-pol2qm74	1694	9	volunteers	volunteer	NNS
cord-015021-pol2qm74	1694	10	(	(	-LRB-
cord-015021-pol2qm74	1694	11	N=8	N=8	NNP
cord-015021-pol2qm74	1694	12	)	)	-RRB-
cord-015021-pol2qm74	1694	13	,	,	,
cord-015021-pol2qm74	1694	14	cultured	culture	VBN
cord-015021-pol2qm74	1694	15	in	in	IN
cord-015021-pol2qm74	1694	16	vitro	vitro	JJ
cord-015021-pol2qm74	1694	17	24	24	CD
cord-015021-pol2qm74	1694	18	hrs	hrs	NN
cord-015021-pol2qm74	1694	19	,	,	,
cord-015021-pol2qm74	1694	20	then	then	RB
cord-015021-pol2qm74	1694	21	pretreated	pretreate	VBD
cord-015021-pol2qm74	1694	22	24	24	CD
cord-015021-pol2qm74	1694	23	hr	hr	NN
cord-015021-pol2qm74	1694	24	_	_	NN
cord-015021-pol2qm74	1695	1	+	+	CC
cord-015021-pol2qm74	1695	2	LPS	LPS	NNP
cord-015021-pol2qm74	1695	3	1-Cultures	1-Cultures	NNPS
cord-015021-pol2qm74	1695	4	were	be	VBD
cord-015021-pol2qm74	1695	5	then	then	RB
cord-015021-pol2qm74	1695	6	stimulated	stimulate	VBN
cord-015021-pol2qm74	1695	7	with	with	IN
cord-015021-pol2qm74	1695	8	LPS	LPS	NNP
cord-015021-pol2qm74	1695	9	2	2	CD
cord-015021-pol2qm74	1695	10	and	and	CC
cord-015021-pol2qm74	1695	11	mediators	mediator	NNS
cord-015021-pol2qm74	1695	12	in	in	IN
cord-015021-pol2qm74	1695	13	MO	MO	NNP
cord-015021-pol2qm74	1695	14	supernatant	supernatant	NN
cord-015021-pol2qm74	1695	15	measured	measure	VBN
cord-015021-pol2qm74	1695	16	:	:	:
cord-015021-pol2qm74	1695	17	TNF	TNF	NNP
cord-015021-pol2qm74	1695	18	,	,	,
cord-015021-pol2qm74	1695	19	IL	IL	NNP
cord-015021-pol2qm74	1695	20	-	-	HYPH
cord-015021-pol2qm74	1695	21	I	I	NNP
cord-015021-pol2qm74	1695	22	,	,	,
cord-015021-pol2qm74	1695	23	and	and	CC
cord-015021-pol2qm74	1695	24	IL-6	IL-6	NNP
cord-015021-pol2qm74	1695	25	by	by	IN
cord-015021-pol2qm74	1695	26	specific	specific	JJ
cord-015021-pol2qm74	1695	27	bioassays	bioassay	NNS
cord-015021-pol2qm74	1695	28	,	,	,
cord-015021-pol2qm74	1695	29	PGE2	PGE2	NNP
cord-015021-pol2qm74	1695	30	by	by	IN
cord-015021-pol2qm74	1695	31	immunoassay	immunoassay	JJ
cord-015021-pol2qm74	1695	32	kit	kit	NN
cord-015021-pol2qm74	1695	33	.	.	.
cord-015021-pol2qm74	1696	1	Serum	serum	NN
cord-015021-pol2qm74	1696	2	cytokine	cytokine	NN
cord-015021-pol2qm74	1696	3	levels	level	NNS
cord-015021-pol2qm74	1696	4	(	(	-LRB-
cord-015021-pol2qm74	1696	5	specific	specific	JJ
cord-015021-pol2qm74	1696	6	ELISA	ELISA	NNP
cord-015021-pol2qm74	1696	7	kits	kit	NNS
cord-015021-pol2qm74	1696	8	)	)	-RRB-
cord-015021-pol2qm74	1696	9	were	be	VBD
cord-015021-pol2qm74	1696	10	compared	compare	VBN
cord-015021-pol2qm74	1696	11	to	to	IN
cord-015021-pol2qm74	1696	12	in	in	FW
cord-015021-pol2qm74	1696	13	vitro	vitro	FW
cord-015021-pol2qm74	1696	14	supernatant	supernatant	JJ
cord-015021-pol2qm74	1696	15	levels	level	NNS
cord-015021-pol2qm74	1696	16	.	.	.
cord-015021-pol2qm74	1697	1	Data	Data	NNP
cord-015021-pol2qm74	1697	2	is	be	VBZ
cord-015021-pol2qm74	1697	3	expressed	express	VBN
cord-015021-pol2qm74	1697	4	as	as	IN
cord-015021-pol2qm74	1697	5	%	%	NN
cord-015021-pol2qm74	1697	6	control_+SEM	control_+sem	NN
cord-015021-pol2qm74	1697	7	,	,	,
cord-015021-pol2qm74	1697	8	LPS2=	LPS2=	JJS
cord-015021-pol2qm74	1697	9	1000	1000	CD
cord-015021-pol2qm74	1697	10	ng	ng	NNP
cord-015021-pol2qm74	1697	11	/	/	SYM
cord-015021-pol2qm74	1697	12	mh	mh	NN
cord-015021-pol2qm74	1698	1	The	the	DT
cord-015021-pol2qm74	1698	2	table	table	NN
cord-015021-pol2qm74	1698	3	shows	show	VBZ
cord-015021-pol2qm74	1698	4	that	that	IN
cord-015021-pol2qm74	1698	5	all	all	DT
cord-015021-pol2qm74	1698	6	mediators	mediator	NNS
cord-015021-pol2qm74	1698	7	were	be	VBD
cord-015021-pol2qm74	1698	8	increased	increase	VBN
cord-015021-pol2qm74	1698	9	,	,	,
cord-015021-pol2qm74	1698	10	in	in	IN
cord-015021-pol2qm74	1698	11	the	the	DT
cord-015021-pol2qm74	1698	12	absence	absence	NN
cord-015021-pol2qm74	1698	13	of	of	IN
cord-015021-pol2qm74	1698	14	LPS	LPS	NNP
cord-015021-pol2qm74	1698	15	1	1	CD
cord-015021-pol2qm74	1698	16	.	.	.
cord-015021-pol2qm74	1699	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	1699	2	with	with	IN
cord-015021-pol2qm74	1699	3	LPS	LPS	NNP
cord-015021-pol2qm74	1699	4	1	1	CD
cord-015021-pol2qm74	1699	5	resulted	result	VBD
cord-015021-pol2qm74	1699	6	in	in	IN
cord-015021-pol2qm74	1699	7	complete	complete	JJ
cord-015021-pol2qm74	1699	8	inhibition	inhibition	NN
cord-015021-pol2qm74	1699	9	of	of	IN
cord-015021-pol2qm74	1699	10	LPS2-triggered	LPS2-triggered	NNP
cord-015021-pol2qm74	1699	11	TNF	TNF	NNP
cord-015021-pol2qm74	1699	12	release	release	NN
cord-015021-pol2qm74	1699	13	.	.	.
cord-015021-pol2qm74	1700	1	In	in	IN
cord-015021-pol2qm74	1700	2	contrast	contrast	NN
cord-015021-pol2qm74	1700	3	,	,	,
cord-015021-pol2qm74	1700	4	LPS	LPS	NNP
cord-015021-pol2qm74	1700	5	1	1	CD
cord-015021-pol2qm74	1700	6	significantly	significantly	RB
cord-015021-pol2qm74	1700	7	increased	increase	VBD
cord-015021-pol2qm74	1700	8	MO	MO	NNP
cord-015021-pol2qm74	1700	9	secretion	secretion	NN
cord-015021-pol2qm74	1700	10	of	of	IN
cord-015021-pol2qm74	1700	11	IL-1	IL-1	NNP
cord-015021-pol2qm74	1700	12	,	,	,
cord-015021-pol2qm74	1700	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	1700	14	and	and	CC
cord-015021-pol2qm74	1700	15	PGE	PGE	NNP
cord-015021-pol2qm74	1700	16	2	2	CD
cord-015021-pol2qm74	1700	17	(	(	-LRB-
cord-015021-pol2qm74	1700	18	data	datum	NNS
cord-015021-pol2qm74	1700	19	not	not	RB
cord-015021-pol2qm74	1700	20	shown	show	VBN
cord-015021-pol2qm74	1700	21	)	)	-RRB-
cord-015021-pol2qm74	1700	22	.	.	.
cord-015021-pol2qm74	1701	1	Serum	serum	NN
cord-015021-pol2qm74	1701	2	cytokine	cytokine	NN
cord-015021-pol2qm74	1701	3	levels	level	NNS
cord-015021-pol2qm74	1701	4	were	be	VBD
cord-015021-pol2qm74	1701	5	as	as	IN
cord-015021-pol2qm74	1701	6	follows	follow	VBZ
cord-015021-pol2qm74	1701	7	:	:	:
cord-015021-pol2qm74	1702	1	TNF	TNF	NNP
cord-015021-pol2qm74	1702	2	407_+21	407_+21	NNP
cord-015021-pol2qm74	1702	3	,	,	,
cord-015021-pol2qm74	1702	4	IL	IL	NNP
cord-015021-pol2qm74	1702	5	-	-	:
cord-015021-pol2qm74	1702	6	I	I	NNP
cord-015021-pol2qm74	1702	7	241	241	CD
cord-015021-pol2qm74	1702	8	+	+	SYM
cord-015021-pol2qm74	1702	9	208	208	CD
cord-015021-pol2qm74	1702	10	,	,	,
cord-015021-pol2qm74	1702	11	and	and	CC
cord-015021-pol2qm74	1702	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	1702	13	8.0-+2.5	8.0-+2.5	NNP
cord-015021-pol2qm74	1702	14	ng	ng	NNP
cord-015021-pol2qm74	1702	15	/	/	SYM
cord-015021-pol2qm74	1702	16	ml	ml	NN
cord-015021-pol2qm74	1702	17	.	.	.
cord-015021-pol2qm74	1703	1	These	these	DT
cord-015021-pol2qm74	1703	2	serum	serum	NN
cord-015021-pol2qm74	1703	3	levels	level	NNS
cord-015021-pol2qm74	1703	4	were	be	VBD
cord-015021-pol2qm74	1703	5	low	low	JJ
cord-015021-pol2qm74	1703	6	,	,	,
cord-015021-pol2qm74	1703	7	showed	show	VBD
cord-015021-pol2qm74	1703	8	an	an	DT
cord-015021-pol2qm74	1703	9	extremely	extremely	RB
cord-015021-pol2qm74	1703	10	wide	wide	JJ
cord-015021-pol2qm74	1703	11	variation	variation	NN
cord-015021-pol2qm74	1703	12	,	,	,
cord-015021-pol2qm74	1703	13	and	and	CC
cord-015021-pol2qm74	1703	14	did	do	VBD
cord-015021-pol2qm74	1703	15	not	not	RB
cord-015021-pol2qm74	1703	16	correlate	correlate	VB
cord-015021-pol2qm74	1703	17	with	with	IN
cord-015021-pol2qm74	1703	18	in	in	IN
cord-015021-pol2qm74	1703	19	vitro	vitro	FW
cord-015021-pol2qm74	1703	20	LPS2-triggered	lps2-triggered	JJ
cord-015021-pol2qm74	1703	21	mediator	mediator	NN
cord-015021-pol2qm74	1703	22	production	production	NN
cord-015021-pol2qm74	1703	23	.	.	.
cord-015021-pol2qm74	1704	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	1704	2	:	:	:
cord-015021-pol2qm74	1704	3	Human	human	JJ
cord-015021-pol2qm74	1704	4	monoeyte	monoeyte	JJ
cord-015021-pol2qm74	1704	5	mediator	mediator	NN
cord-015021-pol2qm74	1704	6	production	production	NN
cord-015021-pol2qm74	1704	7	is	be	VBZ
cord-015021-pol2qm74	1704	8	differentially	differentially	RB
cord-015021-pol2qm74	1704	9	regulated	regulate	VBN
cord-015021-pol2qm74	1704	10	by	by	IN
cord-015021-pol2qm74	1704	11	preexposure	preexposure	NN
cord-015021-pol2qm74	1704	12	to	to	IN
cord-015021-pol2qm74	1704	13	LPS	LPS	NNP
cord-015021-pol2qm74	1704	14	1	1	CD
cord-015021-pol2qm74	1704	15	.	.	.
cord-015021-pol2qm74	1705	1	Provocative	provocative	JJ
cord-015021-pol2qm74	1705	2	in	in	IN
cord-015021-pol2qm74	1705	3	vitro	vitro	FW
cord-015021-pol2qm74	1705	4	testing	testing	NN
cord-015021-pol2qm74	1705	5	of	of	IN
cord-015021-pol2qm74	1705	6	monocytes	monocyte	NNS
cord-015021-pol2qm74	1705	7	may	may	MD
cord-015021-pol2qm74	1705	8	ultimately	ultimately	RB
cord-015021-pol2qm74	1705	9	be	be	VB
cord-015021-pol2qm74	1705	10	clinically	clinically	RB
cord-015021-pol2qm74	1705	11	useful	useful	JJ
cord-015021-pol2qm74	1705	12	to	to	TO
cord-015021-pol2qm74	1705	13	identify	identify	VB
cord-015021-pol2qm74	1705	14	prior	prior	RB
cord-015021-pol2qm74	1705	15	in	in	IN
cord-015021-pol2qm74	1705	16	vivo	vivo	NNP
cord-015021-pol2qm74	1705	17	LPS	LPS	NNP
cord-015021-pol2qm74	1705	18	exposure	exposure	NN
cord-015021-pol2qm74	1705	19	or	or	CC
cord-015021-pol2qm74	1705	20	MO	MO	NNP
cord-015021-pol2qm74	1705	21	Macrophages	macrophage	NNS
cord-015021-pol2qm74	1706	1	release	release	VB
cord-015021-pol2qm74	1706	2	numerous	numerous	JJ
cord-015021-pol2qm74	1706	3	secretory	secretory	JJ
cord-015021-pol2qm74	1706	4	products	product	NNS
cord-015021-pol2qm74	1706	5	involved	involve	VBN
cord-015021-pol2qm74	1706	6	in	in	IN
cord-015021-pol2qm74	1706	7	host	host	NN
cord-015021-pol2qm74	1706	8	defense	defense	NN
cord-015021-pol2qm74	1706	9	and	and	CC
cord-015021-pol2qm74	1706	10	inflammation	inflammation	NN
cord-015021-pol2qm74	1706	11	.	.	.
cord-015021-pol2qm74	1707	1	Activated	activate	VBN
cord-015021-pol2qm74	1707	2	macrophages	macrophage	NNS
cord-015021-pol2qm74	1707	3	with	with	IN
cord-015021-pol2qm74	1707	4	cytokines	cytokine	NNS
cord-015021-pol2qm74	1707	5	produced	produce	VBN
cord-015021-pol2qm74	1707	6	have	have	VBP
cord-015021-pol2qm74	1707	7	been	be	VBN
cord-015021-pol2qm74	1707	8	implicated	implicate	VBN
cord-015021-pol2qm74	1707	9	in	in	IN
cord-015021-pol2qm74	1707	10	tissue	tissue	NN
cord-015021-pol2qm74	1707	11	damage	damage	NN
cord-015021-pol2qm74	1707	12	in	in	IN
cord-015021-pol2qm74	1707	13	sepsis	sepsis	NN
cord-015021-pol2qm74	1707	14	and	and	CC
cord-015021-pol2qm74	1707	15	multiple	multiple	JJ
cord-015021-pol2qm74	1707	16	organ	organ	NN
cord-015021-pol2qm74	1707	17	dysfunction	dysfunction	NN
cord-015021-pol2qm74	1707	18	.	.	.
cord-015021-pol2qm74	1708	1	Aimed	aim	VBN
cord-015021-pol2qm74	1708	2	to	to	TO
cord-015021-pol2qm74	1708	3	elucidate	elucidate	VB
cord-015021-pol2qm74	1708	4	the	the	DT
cord-015021-pol2qm74	1708	5	organ	organ	NN
cord-015021-pol2qm74	1708	6	-	-	HYPH
cord-015021-pol2qm74	1708	7	association	association	NN
cord-015021-pol2qm74	1708	8	phenomena	phenomena	NN
cord-015021-pol2qm74	1708	9	,	,	,
cord-015021-pol2qm74	1708	10	this	this	DT
cord-015021-pol2qm74	1708	11	study	study	NN
cord-015021-pol2qm74	1708	12	is	be	VBZ
cord-015021-pol2qm74	1708	13	to	to	TO
cord-015021-pol2qm74	1708	14	compare	compare	VB
cord-015021-pol2qm74	1708	15	peritoneal	peritoneal	NN
cord-015021-pol2qm74	1708	16	macrophage(PM),alveolar	macrophage(PM),alveolar	NNP
cord-015021-pol2qm74	1708	17	macrophage(AM	macrophage(AM	NNP
cord-015021-pol2qm74	1708	18	)	)	-RRB-
cord-015021-pol2qm74	1708	19	,	,	,
cord-015021-pol2qm74	1708	20	and	and	CC
cord-015021-pol2qm74	1708	21	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	1708	22	cells(KC	cells(kc	CD
cord-015021-pol2qm74	1708	23	)	)	-RRB-
cord-015021-pol2qm74	1709	1	during	during	IN
cord-015021-pol2qm74	1709	2	sepsis	sepsis	NN
cord-015021-pol2qm74	1709	3	in	in	IN
cord-015021-pol2qm74	1709	4	terms	term	NNS
cord-015021-pol2qm74	1709	5	of	of	IN
cord-015021-pol2qm74	1709	6	cellular	cellular	JJ
cord-015021-pol2qm74	1709	7	protein	protein	NN
cord-015021-pol2qm74	1709	8	contents	content	NNS
cord-015021-pol2qm74	1709	9	as	as	IN
cord-015021-pol2qm74	1709	10	symbol	symbol	NN
cord-015021-pol2qm74	1709	11	of	of	IN
cord-015021-pol2qm74	1709	12	activation	activation	NN
cord-015021-pol2qm74	1709	13	by	by	IN
cord-015021-pol2qm74	1709	14	flow	flow	NN
cord-015021-pol2qm74	1709	15	cytometry	cytometry	NN
cord-015021-pol2qm74	1709	16	analysis	analysis	NN
cord-015021-pol2qm74	1709	17	.	.	.
cord-015021-pol2qm74	1710	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	1710	2	were	be	VBD
cord-015021-pol2qm74	1710	3	produced	produce	VBN
cord-015021-pol2qm74	1710	4	by	by	IN
cord-015021-pol2qm74	1710	5	cecal	cecal	JJ
cord-015021-pol2qm74	1710	6	ligatien	ligatien	NNP
cord-015021-pol2qm74	1710	7	and	and	CC
cord-015021-pol2qm74	1710	8	perforation	perforation	NN
cord-015021-pol2qm74	1710	9	(	(	-LRB-
cord-015021-pol2qm74	1710	10	CLP	CLP	NNP
cord-015021-pol2qm74	1710	11	)	)	-RRB-
cord-015021-pol2qm74	1710	12	in	in	IN
cord-015021-pol2qm74	1710	13	Wistar	Wistar	NNP
cord-015021-pol2qm74	1710	14	rats	rat	NNS
cord-015021-pol2qm74	1710	15	weighing	weigh	VBG
cord-015021-pol2qm74	1710	16	210	210	CD
cord-015021-pol2qm74	1710	17	-	-	SYM
cord-015021-pol2qm74	1710	18	290	290	CD
cord-015021-pol2qm74	1710	19	g	g	NN
cord-015021-pol2qm74	1710	20	.	.	.
cord-015021-pol2qm74	1711	1	PM	pm	NN
cord-015021-pol2qm74	1711	2	were	be	VBD
cord-015021-pol2qm74	1711	3	obtained	obtain	VBN
cord-015021-pol2qm74	1711	4	by	by	IN
cord-015021-pol2qm74	1711	5	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	1711	6	lavage	lavage	NN
cord-015021-pol2qm74	1711	7	,	,	,
cord-015021-pol2qm74	1711	8	AM	am	NN
cord-015021-pol2qm74	1711	9	by	by	IN
cord-015021-pol2qm74	1711	10	bronchial	bronchial	JJ
cord-015021-pol2qm74	1711	11	lavage	lavage	NN
cord-015021-pol2qm74	1711	12	and	and	CC
cord-015021-pol2qm74	1711	13	KC	KC	NNP
cord-015021-pol2qm74	1711	14	by	by	IN
cord-015021-pol2qm74	1711	15	incubating	incubate	VBG
cord-015021-pol2qm74	1711	16	the	the	DT
cord-015021-pol2qm74	1711	17	collegenase	collegenase	NNP
cord-015021-pol2qm74	1711	18	digested	digest	VBN
cord-015021-pol2qm74	1711	19	liver	liver	NN
cord-015021-pol2qm74	1711	20	with	with	IN
cord-015021-pol2qm74	1711	21	pronase	pronase	NNP
cord-015021-pol2qm74	1711	22	-	-	HYPH
cord-015021-pol2qm74	1711	23	E.	E.	NNP
cord-015021-pol2qm74	1711	24	Leukocytes	Leukocytes	NNP
cord-015021-pol2qm74	1711	25	have	have	VBP
cord-015021-pol2qm74	1711	26	been	be	VBN
cord-015021-pol2qm74	1711	27	implicated	implicate	VBN
cord-015021-pol2qm74	1711	28	as	as	IN
cord-015021-pol2qm74	1711	29	a	a	DT
cord-015021-pol2qm74	1711	30	mediator	mediator	NN
cord-015021-pol2qm74	1711	31	of	of	IN
cord-015021-pol2qm74	1711	32	the	the	DT
cord-015021-pol2qm74	1711	33	microvascular	microvascular	JJ
cord-015021-pol2qm74	1711	34	dysfunction	dysfunction	NN
cord-015021-pol2qm74	1711	35	associated	associate	VBN
cord-015021-pol2qm74	1711	36	with	with	IN
cord-015021-pol2qm74	1711	37	reperfasion	reperfasion	NN
cord-015021-pol2qm74	1711	38	of	of	IN
cord-015021-pol2qm74	1711	39	ischemic	ischemic	JJ
cord-015021-pol2qm74	1711	40	tissues	tissue	NNS
cord-015021-pol2qm74	1711	41	.	.	.
cord-015021-pol2qm74	1712	1	A	a	DT
cord-015021-pol2qm74	1712	2	role	role	NN
cord-015021-pol2qm74	1712	3	for	for	IN
cord-015021-pol2qm74	1712	4	Ieukocytes	Ieukocytes	NNPS
cord-015021-pol2qm74	1712	5	is	be	VBZ
cord-015021-pol2qm74	1712	6	largely	largely	RB
cord-015021-pol2qm74	1712	7	based	base	VBN
cord-015021-pol2qm74	1712	8	on	on	IN
cord-015021-pol2qm74	1712	9	observations	observation	NNS
cord-015021-pol2qm74	1712	10	that	that	IN
cord-015021-pol2qm74	1712	11	rendering	render	VBG
cord-015021-pol2qm74	1712	12	animals	animal	NNS
cord-015021-pol2qm74	1712	13	anutropenic	anutropenic	JJ
cord-015021-pol2qm74	1712	14	with	with	IN
cord-015021-pol2qm74	1712	15	anti	anti	JJ
cord-015021-pol2qm74	1712	16	-	-	JJ
cord-015021-pol2qm74	1712	17	neutrophil	neutrophil	JJ
cord-015021-pol2qm74	1712	18	serum	serum	NN
cord-015021-pol2qm74	1712	19	or	or	CC
cord-015021-pol2qm74	1712	20	preventing	prevent	VBG
cord-015021-pol2qm74	1712	21	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1712	22	adhesion	adhesion	NN
cord-015021-pol2qm74	1712	23	with	with	IN
cord-015021-pol2qm74	1712	24	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1712	25	antibodies	antibody	NNS
cord-015021-pol2qm74	1712	26	attenuates	attenuate	VBZ
cord-015021-pol2qm74	1712	27	the	the	DT
cord-015021-pol2qm74	1712	28	increased	increase	VBN
cord-015021-pol2qm74	1712	29	fluid	fluid	NN
cord-015021-pol2qm74	1712	30	and	and	CC
cord-015021-pol2qm74	1712	31	protein	protein	NN
cord-015021-pol2qm74	1712	32	leakage	leakage	NN
cord-015021-pol2qm74	1712	33	from	from	IN
cord-015021-pol2qm74	1712	34	the	the	DT
cord-015021-pol2qm74	1712	35	vaseulature	vaseulature	NN
cord-015021-pol2qm74	1712	36	that	that	WDT
cord-015021-pol2qm74	1712	37	is	be	VBZ
cord-015021-pol2qm74	1712	38	normally	normally	RB
cord-015021-pol2qm74	1712	39	observed	observe	VBN
cord-015021-pol2qm74	1712	40	in	in	IN
cord-015021-pol2qm74	1712	41	postischemic	postischemic	JJ
cord-015021-pol2qm74	1712	42	tissues	tissue	NNS
cord-015021-pol2qm74	1712	43	.	.	.
cord-015021-pol2qm74	1713	1	We	-PRON-	PRP
cord-015021-pol2qm74	1713	2	have	have	VBP
cord-015021-pol2qm74	1713	3	recently	recently	RB
cord-015021-pol2qm74	1713	4	undertaken	undertake	VBN
cord-015021-pol2qm74	1713	5	studies	study	NNS
cord-015021-pol2qm74	1713	6	designed	design	VBN
cord-015021-pol2qm74	1713	7	to	to	TO
cord-015021-pol2qm74	1713	8	determine	determine	VB
cord-015021-pol2qm74	1713	9	the	the	DT
cord-015021-pol2qm74	1713	10	relationship	relationship	NN
cord-015021-pol2qm74	1713	11	between	between	IN
cord-015021-pol2qm74	1713	12	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1713	13	-	-	HYPH
cord-015021-pol2qm74	1713	14	endothelial	endothelial	JJ
cord-015021-pol2qm74	1713	15	cell	cell	NN
cord-015021-pol2qm74	1713	16	adhesion	adhesion	NN
cord-015021-pol2qm74	1713	17	and	and	CC
cord-015021-pol2qm74	1713	18	albumin	albumin	NN
cord-015021-pol2qm74	1713	19	leakage	leakage	NN
cord-015021-pol2qm74	1713	20	ia	ia	NNP
cord-015021-pol2qm74	1713	21	rat	rat	NNP
cord-015021-pol2qm74	1713	22	mesenterlc	mesenterlc	NNP
cord-015021-pol2qm74	1713	23	venules	venule	NNS
cord-015021-pol2qm74	1713	24	exposed	expose	VBN
cord-015021-pol2qm74	1714	1	~o	~o	NFP
cord-015021-pol2qm74	1714	2	ischemia	ischemia	NN
cord-015021-pol2qm74	1714	3	-	-	HYPH
cord-015021-pol2qm74	1714	4	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1714	5	(	(	-LRB-
cord-015021-pol2qm74	1714	6	I	i	NN
cord-015021-pol2qm74	1714	7	/	/	SYM
cord-015021-pol2qm74	1714	8	R	r	NN
cord-015021-pol2qm74	1714	9	)	)	-RRB-
cord-015021-pol2qm74	1714	10	.	.	.
cord-015021-pol2qm74	1715	1	Leukocyte	Leukocyte	NNP
cord-015021-pol2qm74	1715	2	adherence	adherence	NN
cord-015021-pol2qm74	1715	3	and	and	CC
cord-015021-pol2qm74	1715	4	emigration	emigration	NN
cord-015021-pol2qm74	1715	5	as	as	RB
cord-015021-pol2qm74	1715	6	well	well	RB
cord-015021-pol2qm74	1715	7	as	as	IN
cord-015021-pol2qm74	1715	8	albumin	albumin	NN
cord-015021-pol2qm74	1715	9	extravasafion	extravasafion	NN
cord-015021-pol2qm74	1715	10	were	be	VBD
cord-015021-pol2qm74	1715	11	monitored	monitor	VBN
cord-015021-pol2qm74	1715	12	in	in	IN
cord-015021-pol2qm74	1715	13	single	single	JJ
cord-015021-pol2qm74	1715	14	postcapillary	postcapillary	JJ
cord-015021-pol2qm74	1715	15	venules	venule	NNS
cord-015021-pol2qm74	1715	16	using	use	VBG
cord-015021-pol2qm74	1715	17	iatravital	iatravital	JJ
cord-015021-pol2qm74	1715	18	fluorescence	fluorescence	NN
cord-015021-pol2qm74	1715	19	microscopy	microscopy	NN
cord-015021-pol2qm74	1715	20	,	,	,
cord-015021-pol2qm74	1715	21	lschemia	lschemia	NNP
cord-015021-pol2qm74	1715	22	was	be	VBD
cord-015021-pol2qm74	1715	23	induced	induce	VBN
cord-015021-pol2qm74	1715	24	by	by	IN
cord-015021-pol2qm74	1715	25	complete	complete	JJ
cord-015021-pol2qm74	1715	26	occ!usion	occ!usion	NN
cord-015021-pol2qm74	1715	27	of	of	IN
cord-015021-pol2qm74	1715	28	the	the	DT
cord-015021-pol2qm74	1715	29	superior	superior	JJ
cord-015021-pol2qm74	1715	30	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	1715	31	artery	artery	NN
cord-015021-pol2qm74	1715	32	and	and	CC
cord-015021-pol2qm74	1716	1	~dl	~dl	NN
cord-015021-pol2qm74	1716	2	parameters	parameter	NNS
cord-015021-pol2qm74	1716	3	were	be	VBD
cord-015021-pol2qm74	1716	4	monitored	monitor	VBN
cord-015021-pol2qm74	1716	5	at	at	IN
cord-015021-pol2qm74	1716	6	various	various	JJ
cord-015021-pol2qm74	1716	7	intervals	interval	NNS
cord-015021-pol2qm74	1716	8	following	follow	VBG
cord-015021-pol2qm74	1716	9	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1716	10	.	.	.
cord-015021-pol2qm74	1717	1	The	the	DT
cord-015021-pol2qm74	1717	2	magnitude	magnitude	NN
cord-015021-pol2qm74	1717	3	of	of	IN
cord-015021-pol2qm74	1717	4	the	the	DT
cord-015021-pol2qm74	1717	5	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1717	6	adherence	adherence	NN
cord-015021-pol2qm74	1717	7	and	and	CC
cord-015021-pol2qm74	1717	8	emigration	emigration	NN
cord-015021-pol2qm74	1717	9	,	,	,
cord-015021-pol2qm74	1717	10	and	and	CC
cord-015021-pol2qm74	1717	11	albumin	albumin	NN
cord-015021-pol2qm74	1717	12	leakage	leakage	NN
cord-015021-pol2qm74	1717	13	elicited	elicit	VBN
cord-015021-pol2qm74	1717	14	by	by	IN
cord-015021-pol2qm74	1717	15	I	I	NNP
cord-015021-pol2qm74	1717	16	/	/	SYM
cord-015021-pol2qm74	1717	17	R	R	NNP
cord-015021-pol2qm74	1717	18	was	be	VBD
cord-015021-pol2qm74	1717	19	positively	positively	RB
cord-015021-pol2qm74	1717	20	con	con	JJ
cord-015021-pol2qm74	1717	21	-	-	HYPH
cord-015021-pol2qm74	1717	22	elated	elated	JJ
cord-015021-pol2qm74	1717	23	with	with	IN
cord-015021-pol2qm74	1717	24	the	the	DT
cord-015021-pol2qm74	1717	25	duration	duration	NN
cord-015021-pol2qm74	1717	26	of	of	IN
cord-015021-pol2qm74	1717	27	ischemia	ischemia	NN
cord-015021-pol2qm74	1717	28	.	.	.
cord-015021-pol2qm74	1718	1	The	the	DT
cord-015021-pol2qm74	1718	2	albumin	albumin	NN
cord-015021-pol2qm74	1718	3	leakage	leakage	NN
cord-015021-pol2qm74	1718	4	response	response	NN
cord-015021-pol2qm74	1718	5	was	be	VBD
cord-015021-pol2qm74	1718	6	also	also	RB
cord-015021-pol2qm74	1718	7	highly	highly	RB
cord-015021-pol2qm74	1718	8	correlated	correlate	VBN
cord-015021-pol2qm74	1718	9	with	with	IN
cord-015021-pol2qm74	1718	10	the	the	DT
cord-015021-pol2qm74	1718	11	number	number	NN
cord-015021-pol2qm74	1718	12	of	of	IN
cord-015021-pol2qm74	1718	13	adherent	adherent	JJ
cord-015021-pol2qm74	1718	14	and	and	CC
cord-015021-pol2qm74	1718	15	emigrated	emigrate	VBD
cord-015021-pol2qm74	1718	16	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1718	17	.	.	.
cord-015021-pol2qm74	1719	1	Monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1719	2	antibodies	antibody	NNS
cord-015021-pol2qm74	1719	3	against	against	IN
cord-015021-pol2qm74	1719	4	the	the	DT
cord-015021-pol2qm74	1719	5	adhesion	adhesion	NN
cord-015021-pol2qm74	1719	6	glycoproteins	glycoprotein	NNS
cord-015021-pol2qm74	1719	7	CD18	CD18	NNP
cord-015021-pol2qm74	1719	8	,	,	,
cord-015021-pol2qm74	1719	9	CDllb	CDllb	NNP
cord-015021-pol2qm74	1719	10	,	,	,
cord-015021-pol2qm74	1719	11	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1719	12	and	and	CC
cord-015021-pol2qm74	1719	13	L	L	NNP
cord-015021-pol2qm74	1719	14	-	-	HYPH
cord-015021-pol2qm74	1719	15	selectin	selectin	NNP
cord-015021-pol2qm74	1719	16	,	,	,
cord-015021-pol2qm74	1719	17	but	but	CC
cord-015021-pol2qm74	1719	18	not	not	RB
cord-015021-pol2qm74	1719	19	P	p	NN
cord-015021-pol2qm74	1719	20	-	-	,
cord-015021-pol2qm74	1719	21	or	or	CC
cord-015021-pol2qm74	1719	22	E	e	NN
cord-015021-pol2qm74	1719	23	-	-	NN
cord-015021-pol2qm74	1719	24	selecdn	selecdn	JJ
cord-015021-pol2qm74	1719	25	,	,	,
cord-015021-pol2qm74	1719	26	reduced	reduce	VBN
cord-015021-pol2qm74	1719	27	I	I	NNP
cord-015021-pol2qm74	1719	28	/	/	SYM
cord-015021-pol2qm74	1719	29	R	r	NN
cord-015021-pol2qm74	1719	30	-	-	HYPH
cord-015021-pol2qm74	1719	31	induced	induce	VBN
cord-015021-pol2qm74	1719	32	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1719	33	adherence	adherence	NN
cord-015021-pol2qm74	1719	34	and	and	CC
cord-015021-pol2qm74	1719	35	emigration	emigration	NN
cord-015021-pol2qm74	1719	36	as	as	RB
cord-015021-pol2qm74	1719	37	well	well	RB
cord-015021-pol2qm74	1719	38	as	as	IN
cord-015021-pol2qm74	1719	39	albumin	albumin	NN
cord-015021-pol2qm74	1719	40	leakage	leakage	NN
cord-015021-pol2qm74	1719	41	.	.	.
cord-015021-pol2qm74	1720	1	PhaUoidln	PhaUoidln	NNP
cord-015021-pol2qm74	1720	2	,	,	,
cord-015021-pol2qm74	1720	3	an	an	DT
cord-015021-pol2qm74	1720	4	F	F	NNP
cord-015021-pol2qm74	1720	5	-	-	HYPH
cord-015021-pol2qm74	1720	6	aetin	aetin	NNP
cord-015021-pol2qm74	1720	7	stabilizer	stabilizer	NN
cord-015021-pol2qm74	1720	8	,	,	,
cord-015021-pol2qm74	1720	9	largely	largely	RB
cord-015021-pol2qm74	1720	10	prevented	prevent	VBD
cord-015021-pol2qm74	1720	11	the	the	DT
cord-015021-pol2qm74	1720	12	emigration	emigration	NN
cord-015021-pol2qm74	1720	13	(	(	-LRB-
cord-015021-pol2qm74	1720	14	but	but	CC
cord-015021-pol2qm74	1720	15	not	not	RB
cord-015021-pol2qm74	1720	16	adherence	adherence	NN
cord-015021-pol2qm74	1720	17	)	)	-RRB-
cord-015021-pol2qm74	1720	18	of	of	IN
cord-015021-pol2qm74	1720	19	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1720	20	and	and	CC
cord-015021-pol2qm74	1720	21	greatly	greatly	RB
cord-015021-pol2qm74	1720	22	reduced	reduce	VBN
cord-015021-pol2qm74	1720	23	,	,	,
cord-015021-pol2qm74	1720	24	the	the	DT
cord-015021-pol2qm74	1720	25	raicrovascular	raicrovascular	JJ
cord-015021-pol2qm74	1720	26	protein	protein	NN
cord-015021-pol2qm74	1720	27	leakage	leakage	NN
cord-015021-pol2qm74	1720	28	.	.	.
cord-015021-pol2qm74	1721	1	Plateletleukocyte	Plateletleukocyte	NNP
cord-015021-pol2qm74	1721	2	aggregates	aggregate	NNS
cord-015021-pol2qm74	1721	3	were	be	VBD
cord-015021-pol2qm74	1721	4	formed	form	VBN
cord-015021-pol2qm74	1721	5	in	in	IN
cord-015021-pol2qm74	1721	6	postischemic	postischemic	NNP
cord-015021-pol2qm74	1721	7	vemdes	vemde	NNS
cord-015021-pol2qm74	1721	8	;	;	:
cord-015021-pol2qm74	1721	9	the	the	DT
cord-015021-pol2qm74	1721	10	number	number	NN
cord-015021-pol2qm74	1721	11	of	of	IN
cord-015021-pol2qm74	1721	12	aggregates	aggregate	NNS
cord-015021-pol2qm74	1721	13	was	be	VBD
cord-015021-pol2qm74	1721	14	reduced	reduce	VBN
cord-015021-pol2qm74	1721	15	by	by	IN
cord-015021-pol2qm74	1721	16	antibodies	antibody	NNS
cord-015021-pol2qm74	1721	17	against	against	IN
cord-015021-pol2qm74	1721	18	P	p	NN
cord-015021-pol2qm74	1721	19	-	-	HYPH
cord-015021-pol2qm74	1721	20	selecdh	selecdh	NNP
cord-015021-pol2qm74	1721	21	,	,	,
cord-015021-pol2qm74	1721	22	CDIlb	CDIlb	NNP
cord-015021-pol2qm74	1721	23	,	,	,
cord-015021-pol2qm74	1721	24	CD18	CD18	NNP
cord-015021-pol2qm74	1721	25	,	,	,
cord-015021-pol2qm74	1721	26	and	and	CC
cord-015021-pol2qm74	1721	27	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1721	28	,	,	,
cord-015021-pol2qm74	1721	29	but	but	CC
cord-015021-pol2qm74	1721	30	not	not	RB
cord-015021-pol2qm74	1721	31	E	e	NN
cord-015021-pol2qm74	1721	32	-	-	NN
cord-015021-pol2qm74	1721	33	selectin	selectin	JJ
cord-015021-pol2qm74	1721	34	or	or	CC
cord-015021-pol2qm74	1721	35	Lselectin	Lselectin	NNP
cord-015021-pol2qm74	1721	36	.	.	.
cord-015021-pol2qm74	1722	1	A	a	DT
cord-015021-pol2qm74	1722	2	significant	significant	JJ
cord-015021-pol2qm74	1722	3	fraction	fraction	NN
cord-015021-pol2qm74	1722	4	of	of	IN
cord-015021-pol2qm74	1722	5	the	the	DT
cord-015021-pol2qm74	1722	6	mast	mast	NN
cord-015021-pol2qm74	1722	7	ceils	ceil	NNS
cord-015021-pol2qm74	1722	8	surrounding	surround	VBG
cord-015021-pol2qm74	1722	9	the	the	DT
cord-015021-pol2qm74	1722	10	posteapillary	posteapillary	JJ
cord-015021-pol2qm74	1722	11	venules	venule	NNS
cord-015021-pol2qm74	1722	12	degranulated	degranulate	VBN
cord-015021-pol2qm74	1722	13	in	in	IN
cord-015021-pol2qm74	1722	14	response	response	NN
cord-015021-pol2qm74	1722	15	to	to	IN
cord-015021-pol2qm74	1722	16	ischemia	ischemia	NN
cord-015021-pol2qm74	1722	17	/	/	SYM
cord-015021-pol2qm74	1722	18	repeffusion	repeffusion	NN
cord-015021-pol2qm74	1722	19	,	,	,
cord-015021-pol2qm74	1722	20	but	but	CC
cord-015021-pol2qm74	1722	21	mast	mast	JJ
cord-015021-pol2qm74	1722	22	cell	cell	NN
cord-015021-pol2qm74	1722	23	stabilizers	stabilizer	NNS
cord-015021-pol2qm74	1722	24	did	do	VBD
cord-015021-pol2qm74	1722	25	not	not	RB
cord-015021-pol2qm74	1722	26	afford	afford	VB
cord-015021-pol2qm74	1722	27	protection	protection	NN
cord-015021-pol2qm74	1722	28	against	against	IN
cord-015021-pol2qm74	1722	29	the	the	DT
cord-015021-pol2qm74	1722	30	albumin	albumin	NN
cord-015021-pol2qm74	1722	31	leakage	leakage	NN
cord-015021-pol2qm74	1722	32	elicited	elicit	VBN
cord-015021-pol2qm74	1722	33	by	by	IN
cord-015021-pol2qm74	1723	1	I	I	NNP
cord-015021-pol2qm74	1723	2	/	/	SYM
cord-015021-pol2qm74	1723	3	R.	R.	NNP
cord-015021-pol2qm74	1723	4	These	these	DT
cord-015021-pol2qm74	1723	5	results	result	NNS
cord-015021-pol2qm74	1723	6	indicate	indicate	VBP
cord-015021-pol2qm74	1723	7	that	that	IN
cord-015021-pol2qm74	1723	8	reperfusloninduced	reperfusloninduce	VBN
cord-015021-pol2qm74	1723	9	albumin	albumin	NN
cord-015021-pol2qm74	1723	10	leakage	leakage	NN
cord-015021-pol2qm74	1723	11	is	be	VBZ
cord-015021-pol2qm74	1723	12	tightly	tightly	RB
cord-015021-pol2qm74	1723	13	coupled	couple	VBN
cord-015021-pol2qm74	1723	14	to	to	IN
cord-015021-pol2qm74	1723	15	the	the	DT
cord-015021-pol2qm74	1723	16	adherence	adherence	NN
cord-015021-pol2qm74	1723	17	and	and	CC
cord-015021-pol2qm74	1723	18	emigration	emigration	NN
cord-015021-pol2qm74	1723	19	of	of	IN
cord-015021-pol2qm74	1723	20	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1723	21	in	in	IN
cord-015021-pol2qm74	1723	22	posteapillary	posteapillary	NNP
cord-015021-pol2qm74	1723	23	venules	venule	NNS
cord-015021-pol2qm74	1723	24	.	.	.
cord-015021-pol2qm74	1724	1	This	this	DT
cord-015021-pol2qm74	1724	2	adhesiomdependent	adhesiomdependent	NN
cord-015021-pol2qm74	1724	3	injury	injury	NN
cord-015021-pol2qm74	1724	4	response	response	NN
cord-015021-pol2qm74	1724	5	is	be	VBZ
cord-015021-pol2qm74	1724	6	primarily	primarily	RB
cord-015021-pol2qm74	1724	7	mediated	mediate	VBN
cord-015021-pol2qm74	1724	8	by	by	IN
cord-015021-pol2qm74	1724	9	CDllb	CDllb	NNP
cord-015021-pol2qm74	1724	10	/	/	SYM
cord-015021-pol2qm74	1724	11	CDI8	CDI8	NNP
cord-015021-pol2qm74	1724	12	on	on	IN
cord-015021-pol2qm74	1724	13	activated	activate	VBN
cord-015021-pol2qm74	1724	14	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1724	15	and	and	CC
cord-015021-pol2qm74	1724	16	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1724	17	on	on	IN
cord-015021-pol2qm74	1724	18	venular	venular	JJ
cord-015021-pol2qm74	1724	19	endothellum	endothellum	NN
cord-015021-pol2qm74	1724	20	,	,	,
cord-015021-pol2qm74	1724	21	and	and	CC
cord-015021-pol2qm74	1724	22	appears	appear	VBZ
cord-015021-pol2qm74	1724	23	to	to	TO
cord-015021-pol2qm74	1724	24	require	require	VB
cord-015021-pol2qm74	1724	25	L	L	NNP
cord-015021-pol2qm74	1724	26	-	-	HYPH
cord-015021-pol2qm74	1724	27	selecda	selecda	NNP
cord-015021-pol2qm74	1724	28	dependent	dependent	JJ
cord-015021-pol2qm74	1724	29	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1724	30	rolling	rolling	NN
cord-015021-pol2qm74	1724	31	.	.	.
cord-015021-pol2qm74	1725	1	Mast	mast	JJ
cord-015021-pol2qm74	1725	2	cell	cell	NN
cord-015021-pol2qm74	1725	3	degranulation	degranulation	NN
cord-015021-pol2qm74	1725	4	does	do	VBZ
cord-015021-pol2qm74	1725	5	not	not	RB
cord-015021-pol2qm74	1725	6	appear	appear	VB
cord-015021-pol2qm74	1725	7	to	to	TO
cord-015021-pol2qm74	1725	8	conwibate	conwibate	VB
cord-015021-pol2qm74	1725	9	to	to	IN
cord-015021-pol2qm74	1725	10	the	the	DT
cord-015021-pol2qm74	1725	11	vascular	vascular	JJ
cord-015021-pol2qm74	1725	12	pathology	pathology	NN
cord-015021-pol2qm74	1725	13	associated	associate	VBN
cord-015021-pol2qm74	1725	14	with	with	IN
cord-015021-pol2qm74	1725	15	I	I	NNP
cord-015021-pol2qm74	1725	16	/	/	SYM
cord-015021-pol2qm74	1725	17	R.	R.	NNP
cord-015021-pol2qm74	1725	18	M.D.	M.D.	NNP
cord-015021-pol2qm74	1725	19	Rod	Rod	NNP
cord-015021-pol2qm74	1725	20	=	=	SYM
cord-015021-pol2qm74	1725	21	iek	iek	NNP
cord-015021-pol2qm74	1725	22	,	,	,
cord-015021-pol2qm74	1725	23	Boston	Boston	NNP
cord-015021-pol2qm74	1725	24	,	,	,
cord-015021-pol2qm74	1725	25	MA	MA	NNP
cord-015021-pol2qm74	1725	26	,	,	,
cord-015021-pol2qm74	1725	27	USA	USA	NNP
cord-015021-pol2qm74	1726	1	The	the	DT
cord-015021-pol2qm74	1726	2	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	1726	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1726	4	(	(	-LRB-
cord-015021-pol2qm74	1726	5	PMN	PMN	NNP
cord-015021-pol2qm74	1726	6	)	)	-RRB-
cord-015021-pol2qm74	1726	7	has	have	VBZ
cord-015021-pol2qm74	1726	8	long	long	RB
cord-015021-pol2qm74	1726	9	been	be	VBN
cord-015021-pol2qm74	1726	10	known	know	VBN
cord-015021-pol2qm74	1726	11	to	to	IN
cord-015021-pol2qm74	1726	12	pa	pa	NNP
cord-015021-pol2qm74	1727	1	~tlcipats	~tlcipats	XX
cord-015021-pol2qm74	1727	2	in	in	IN
cord-015021-pol2qm74	1727	3	the	the	DT
cord-015021-pol2qm74	1727	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1727	5	reBpons~	reBpons~	NNP
cord-015021-pol2qm74	1727	6	as	as	IN
cord-015021-pol2qm74	1727	7	a	a	DT
cord-015021-pol2qm74	1727	8	phagocyte	phagocyte	NN
cord-015021-pol2qm74	1727	9	and	and	CC
cord-015021-pol2qm74	1727	10	killer	killer	NN
cord-015021-pol2qm74	1727	11	Of	of	IN
cord-015021-pol2qm74	1727	12	invading	invade	VBG
cord-015021-pol2qm74	1727	13	organisms	organism	NNS
cord-015021-pol2qm74	1727	14	,	,	,
cord-015021-pol2qm74	1727	15	but	but	CC
cord-015021-pol2qm74	1727	16	little	little	JJ
cord-015021-pol2qm74	1727	17	attention	attention	NN
cord-015021-pol2qm74	1727	18	has	have	VBZ
cord-015021-pol2qm74	1727	19	been	be	VBN
cord-015021-pol2qm74	1727	20	given	give	VBN
cord-015021-pol2qm74	1727	21	to	to	IN
cord-015021-pol2qm74	1727	22	its	-PRON-	PRP$
cord-015021-pol2qm74	1727	23	potential	potential	NN
cord-015021-pol2qm74	1727	24	as	as	IN
cord-015021-pol2qm74	1727	25	a	a	DT
cord-015021-pol2qm74	1727	26	participant	participant	NN
cord-015021-pol2qm74	1727	27	in	in	IN
cord-015021-pol2qm74	1727	28	the	the	DT
cord-015021-pol2qm74	1727	29	in	in	IN
cord-015021-pol2qm74	1727	30	~	~	CD
cord-015021-pol2qm74	1727	31	une	une	FW
cord-015021-pol2qm74	1727	32	interaction	interaction	NN
cord-015021-pol2qm74	1727	33	of	of	IN
cord-015021-pol2qm74	1727	34	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	1727	35	and	and	CC
cord-015021-pol2qm74	1727	36	macrophages	macrophage	NNS
cord-015021-pol2qm74	1727	37	.	.	.
cord-015021-pol2qm74	1728	1	We	-PRON-	PRP
cord-015021-pol2qm74	1728	2	and	and	CC
cord-015021-pol2qm74	1728	3	others	other	NNS
cord-015021-pol2qm74	1728	4	have	have	VBP
cord-015021-pol2qm74	1728	5	shown	show	VBN
cord-015021-pol2qm74	1728	6	that	that	IN
cord-015021-pol2qm74	1728	7	the	the	DT
cord-015021-pol2qm74	1728	8	PMN	PMN	NNP
cord-015021-pol2qm74	1728	9	may	may	MD
cord-015021-pol2qm74	1728	10	have	have	VB
cord-015021-pol2qm74	1728	11	i	i	PRP
cord-015021-pol2qm74	1728	12	~	~	CD
cord-015021-pol2qm74	1728	13	m~/nomcdulatory	m~/nomcdulatory	CD
cord-015021-pol2qm74	1728	14	effects	effect	NNS
cord-015021-pol2qm74	1728	15	both	both	DT
cord-015021-pol2qm74	1728	16	in	in	IN
cord-015021-pol2qm74	1728	17	vitro	vitro	FW
cord-015021-pol2qm74	1728	18	and	and	CC
cord-015021-pol2qm74	1728	19	in	in	IN
cord-015021-pol2qm74	1728	20	vlvo	vlvo	NNP
cord-015021-pol2qm74	1728	21	.	.	.
cord-015021-pol2qm74	1729	1	More	more	RBR
cord-015021-pol2qm74	1729	2	recently	recently	RB
cord-015021-pol2qm74	1729	3	it	-PRON-	PRP
cord-015021-pol2qm74	1729	4	has	have	VBZ
cord-015021-pol2qm74	1729	5	been	be	VBN
cord-015021-pol2qm74	1729	6	proven	prove	VBN
cord-015021-pol2qm74	1729	7	that	that	IN
cord-015021-pol2qm74	1729	8	the	the	DT
cord-015021-pol2qm74	1729	9	PMN	PMN	NNP
cord-015021-pol2qm74	1729	10	can	can	MD
cord-015021-pol2qm74	1729	11	make	make	VB
cord-015021-pol2qm74	1729	12	mRNA	mrna	NN
cord-015021-pol2qm74	1729	13	for	for	IN
cord-015021-pol2qm74	1729	14	and	and	CC
cord-015021-pol2qm74	1729	15	secrete	secrete	VB
cord-015021-pol2qm74	1729	16	the	the	DT
cord-015021-pol2qm74	1729	17	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	1729	18	oytokines	oytokine	NNS
cord-015021-pol2qm74	1729	19	ILla	ILla	NNP
cord-015021-pol2qm74	1729	20	,	,	,
cord-015021-pol2qm74	1729	21	IL	IL	NNP
cord-015021-pol2qm74	1729	22	-	-	HYPH
cord-015021-pol2qm74	1729	23	IB	IB	NNP
cord-015021-pol2qm74	1729	24	,	,	,
cord-015021-pol2qm74	1729	25	TNFS	TNFS	NNP
cord-015021-pol2qm74	1729	26	,	,	,
cord-015021-pol2qm74	1729	27	IL-6	IL-6	NNP
cord-015021-pol2qm74	1729	28	and	and	CC
cord-015021-pol2qm74	1729	29	IL-8	IL-8	NNP
cord-015021-pol2qm74	1729	30	as	as	IN
cord-015021-pol2qm74	1729	31	does	do	VBZ
cord-015021-pol2qm74	1729	32	the	the	DT
cord-015021-pol2qm74	1729	33	other	other	JJ
cord-015021-pol2qm74	1729	34	major	major	JJ
cord-015021-pol2qm74	1729	35	circulating	circulate	VBG
cord-015021-pol2qm74	1729	36	phagocyte	phagocyte	NNP
cord-015021-pol2qm74	1729	37	,	,	,
cord-015021-pol2qm74	1729	38	the	the	DT
cord-015021-pol2qm74	1729	39	monocyte	monocyte	NNP
cord-015021-pol2qm74	1729	40	/	/	SYM
cord-015021-pol2qm74	1729	41	macrophags	macrophags	NNP
cord-015021-pol2qm74	1729	42	.	.	.
cord-015021-pol2qm74	1730	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	1730	2	it	-PRON-	PRP
cord-015021-pol2qm74	1730	3	has	have	VBZ
cord-015021-pol2qm74	1730	4	been	be	VBN
cord-015021-pol2qm74	1730	5	shown	show	VBN
cord-015021-pol2qm74	1730	6	to	to	TO
cord-015021-pol2qm74	1730	7	make	make	VB
cord-015021-pol2qm74	1730	8	the	the	DT
cord-015021-pol2qm74	1730	9	potentially	potentially	RB
cord-015021-pol2qm74	1730	10	autoregulatory	autoregulatory	NNP
cord-015021-pol2qm74	1730	11	oytokines	oytokines	NNP
cord-015021-pol2qm74	1730	12	GCSF	GCSF	NNP
cord-015021-pol2qm74	1730	13	and	and	CC
cord-015021-pol2qm74	1730	14	GMCSF	GMCSF	NNP
cord-015021-pol2qm74	1730	15	.	.	.
cord-015021-pol2qm74	1731	1	These	these	DT
cord-015021-pol2qm74	1731	2	functional	functional	JJ
cord-015021-pol2qm74	1731	3	capabilities	capability	NNS
cord-015021-pol2qm74	1731	4	suggest	suggest	VBP
cord-015021-pol2qm74	1731	5	that	that	IN
cord-015021-pol2qm74	1731	6	the	the	DT
cord-015021-pol2qm74	1731	7	PMN	PMN	NNP
cord-015021-pol2qm74	1731	8	is	be	VBZ
cord-015021-pol2qm74	1731	9	not	not	RB
cord-015021-pol2qm74	1731	10	an	an	DT
cord-015021-pol2qm74	1731	11	Wend	Wend	NNP
cord-015021-pol2qm74	1731	12	cell	cell	NN
cord-015021-pol2qm74	1731	13	~	~	NFP
cord-015021-pol2qm74	1731	14	,	,	,
cord-015021-pol2qm74	1731	15	but	but	CC
cord-015021-pol2qm74	1731	16	one	one	NN
cord-015021-pol2qm74	1731	17	which	which	WDT
cord-015021-pol2qm74	1731	18	has	have	VBZ
cord-015021-pol2qm74	1731	19	a	a	DT
cord-015021-pol2qm74	1731	20	potential	potential	JJ
cord-015021-pol2qm74	1731	21	role	role	NN
cord-015021-pol2qm74	1731	22	in	in	IN
cord-015021-pol2qm74	1731	23	regulation	regulation	NN
cord-015021-pol2qm74	1731	24	cf	cf	NN
cord-015021-pol2qm74	1732	1	~he	~he	NNP
cord-015021-pol2qm74	1732	2	immune	immune	JJ
cord-015021-pol2qm74	1732	3	response	response	NN
cord-015021-pol2qm74	1732	4	and	and	CC
cord-015021-pol2qm74	1732	5	that	that	IN
cord-015021-pol2qm74	1732	6	this	this	DT
cord-015021-pol2qm74	1732	7	potential	potential	NN
cord-015021-pol2qm74	1732	8	~cle	~cle	NNP
cord-015021-pol2qm74	1732	9	should	should	MD
cord-015021-pol2qm74	1732	10	no	no	RB
cord-015021-pol2qm74	1732	11	longer	longer	RB
cord-015021-pol2qm74	1732	12	be	be	VB
cord-015021-pol2qm74	1732	13	ignored	ignore	VBN
cord-015021-pol2qm74	1732	14	when	when	WRB
cord-015021-pol2qm74	1732	15	considering	consider	VBG
cord-015021-pol2qm74	1732	16	the	the	DT
cord-015021-pol2qm74	1732	17	immune	immune	JJ
cord-015021-pol2qm74	1732	18	abnormalities	abnormality	NNS
cord-015021-pol2qm74	1732	19	existing	exist	VBG
cord-015021-pol2qm74	1732	20	in	in	IN
cord-015021-pol2qm74	1732	21	patients	patient	NNS
cord-015021-pol2qm74	1732	22	following	follow	VBG
cord-015021-pol2qm74	1732	23	maJo~	majo~	CD
cord-015021-pol2qm74	1732	24	injury	injury	NN
cord-015021-pol2qm74	1732	25	or	or	CC
cord-015021-pol2qm74	1732	26	surgery	surgery	NN
cord-015021-pol2qm74	1732	27	.	.	.
cord-015021-pol2qm74	1733	1	We	-PRON-	PRP
cord-015021-pol2qm74	1733	2	have	have	VBP
cord-015021-pol2qm74	1733	3	investigated	investigate	VBN
cord-015021-pol2qm74	1733	4	the	the	DT
cord-015021-pol2qm74	1733	5	proinflaznmatory	proinflaznmatory	JJ
cord-015021-pol2qm74	1733	6	oytokine	oytokine	JJ
cord-015021-pol2qm74	1733	7	secretion	secretion	NN
cord-015021-pol2qm74	1733	8	patter~	patter~	VBN
cord-015021-pol2qm74	1733	9	by	by	IN
cord-015021-pol2qm74	1733	10	PMN	PMN	NNP
cord-015021-pol2qm74	1733	11	in	in	IN
cord-015021-pol2qm74	1733	12	patients	patient	NNS
cord-015021-pol2qm74	1733	13	following	follow	VBG
cord-015021-pol2qm74	1733	14	major	major	JJ
cord-015021-pol2qm74	1733	15	~hermal	~hermal	NNP
cord-015021-pol2qm74	1733	16	or	or	CC
cord-015021-pol2qm74	1733	17	tra	tra	NNP
cord-015021-pol2qm74	1733	18	~	~	NNP
cord-015021-pol2qm74	1733	19	matic	matic	NNP
cord-015021-pol2qm74	1733	20	injury	injury	NN
cord-015021-pol2qm74	1733	21	and	and	CC
cord-015021-pol2qm74	1733	22	in	in	IN
cord-015021-pol2qm74	1733	23	volunteers	volunteer	NNS
cord-015021-pol2qm74	1733	24	fellowinq	fellowinq	NN
cord-015021-pol2qm74	1733	25	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	1733	26	.	.	.
cord-015021-pol2qm74	1733	27	?	?	.
cord-015021-pol2qm74	1734	1	ollowing	ollowe	VBG
cord-015021-pol2qm74	1734	2	major	major	JJ
cord-015021-pol2qm74	1734	3	injury	injury	NN
cord-015021-pol2qm74	1734	4	there	there	EX
cord-015021-pol2qm74	1734	5	is	be	VBZ
cord-015021-pol2qm74	1734	6	variable	variable	JJ
cord-015021-pol2qm74	1734	7	PMN	PMN	NNP
cord-015021-pol2qm74	1734	8	secretion	secretion	NN
cord-015021-pol2qm74	1734	9	of	of	IN
cord-015021-pol2qm74	1734	10	these	these	DT
cord-015021-pol2qm74	1734	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	1734	12	when	when	WRB
cord-015021-pol2qm74	1734	13	stimulated	stimulate	VBN
cord-015021-pol2qm74	1734	14	in	in	IN
cord-015021-pol2qm74	1734	15	vlero	vlero	NNP
cord-015021-pol2qm74	1734	16	.	.	.
cord-015021-pol2qm74	1735	1	Following	follow	VBG
cord-015021-pol2qm74	1735	2	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	1735	3	in	in	IN
cord-015021-pol2qm74	1735	4	a	a	DT
cord-015021-pol2qm74	1735	5	group	group	NN
cord-015021-pol2qm74	1735	6	of	of	IN
cord-015021-pol2qm74	1735	7	human	human	JJ
cord-015021-pol2qm74	1735	8	volunteers	volunteer	NNS
cord-015021-pol2qm74	1735	9	PMN	PMN	NNP
cord-015021-pol2qm74	1735	10	showed	show	VBD
cord-015021-pol2qm74	1735	11	a	a	DT
cord-015021-pol2qm74	1735	12	hypo	hypo	NN
cord-015021-pol2qm74	1736	1	=	=	SYM
cord-015021-pol2qm74	1736	2	esponsivenesa	esponsivenesa	VBN
cord-015021-pol2qm74	1736	3	to	to	IN
cord-015021-pol2qm74	1736	4	LPS	LPS	NNP
cord-015021-pol2qm74	1736	5	4	4	CD
cord-015021-pol2qm74	1736	6	hrs	hrs	NN
cord-015021-pol2qm74	1736	7	following	follow	VBG
cord-015021-pol2qm74	1736	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1736	9	infusion	infusion	NN
cord-015021-pol2qm74	1736	10	followed	follow	VBD
cord-015021-pol2qm74	1736	11	at	at	IN
cord-015021-pol2qm74	1736	12	24	24	CD
cord-015021-pol2qm74	1736	13	hre	hre	NNP
cord-015021-pol2qm74	1736	14	by	by	IN
cord-015021-pol2qm74	1736	15	an	an	DT
cord-015021-pol2qm74	1736	16	overshoot	overshoot	NN
cord-015021-pol2qm74	1736	17	.	.	.
cord-015021-pol2qm74	1737	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	1737	2	with	with	IN
cord-015021-pol2qm74	1737	3	steroids	steroid	NNS
cord-015021-pol2qm74	1737	4	modulated	modulate	VBN
cord-015021-pol2qm74	1737	5	this	this	DT
cord-015021-pol2qm74	1737	6	overshoot	overshoot	NN
cord-015021-pol2qm74	1737	7	phenomenon	phenomenon	NN
cord-015021-pol2qm74	1737	8	,	,	,
cord-015021-pol2qm74	1737	9	suggesting	suggest	VBG
cord-015021-pol2qm74	1737	10	that	that	IN
cord-015021-pol2qm74	1737	11	receptors	receptor	NNS
cord-015021-pol2qm74	1737	12	for	for	IN
cord-015021-pol2qm74	1737	13	steroids	steroid	NNS
cord-015021-pol2qm74	1737	14	are	be	VBP
cord-015021-pol2qm74	1737	15	involved	involve	VBN
cord-015021-pol2qm74	1737	16	in	in	IN
cord-015021-pol2qm74	1737	17	the	the	DT
cord-015021-pol2qm74	1737	18	regulation	regulation	NN
cord-015021-pol2qm74	1737	19	of	of	IN
cord-015021-pol2qm74	1737	20	cytokin	cytokin	NNP
cord-015021-pol2qm74	1738	1	®	®	NNP
cord-015021-pol2qm74	1738	2	secretlon	secretlon	NNP
cord-015021-pol2qm74	1738	3	by	by	IN
cord-015021-pol2qm74	1738	4	FMN	FMN	NNP
cord-015021-pol2qm74	1738	5	.	.	.
cord-015021-pol2qm74	1739	1	These	these	DT
cord-015021-pol2qm74	1739	2	results	result	NNS
cord-015021-pol2qm74	1739	3	sugges~	sugges~	JJ
cord-015021-pol2qm74	1739	4	that	that	IN
cord-015021-pol2qm74	1739	5	the	the	DT
cord-015021-pol2qm74	1739	6	PMN	PMN	NNP
cord-015021-pol2qm74	1739	7	,	,	,
cord-015021-pol2qm74	1739	8	the	the	DT
cord-015021-pol2qm74	1739	9	most	most	RBS
cord-015021-pol2qm74	1739	10	numerous	numerous	JJ
cord-015021-pol2qm74	1739	11	cell	cell	NN
cord-015021-pol2qm74	1739	12	in	in	IN
cord-015021-pol2qm74	1739	13	the	the	DT
cord-015021-pol2qm74	1739	14	circulation	circulation	NN
cord-015021-pol2qm74	1739	15	and	and	CC
cord-015021-pol2qm74	1739	16	the	the	DT
cord-015021-pol2qm74	1739	17	first	first	JJ
cord-015021-pol2qm74	1739	18	to	to	TO
cord-015021-pol2qm74	1739	19	respond	respond	VB
cord-015021-pol2qm74	1739	20	to	to	IN
cord-015021-pol2qm74	1739	21	an	an	DT
cord-015021-pol2qm74	1739	22	ins	in	NNS
cord-015021-pol2qm74	1739	23	~	~	NFP
cord-015021-pol2qm74	1739	24	l~	l~	XX
cord-015021-pol2qm74	1739	25	may	may	MD
cord-015021-pol2qm74	1739	26	be	be	VB
cord-015021-pol2qm74	1739	27	a	a	DT
cord-015021-pol2qm74	1739	28	so	so	RB
cord-015021-pol2qm74	1740	1	~rce	~rce	NNP
cord-015021-pol2qm74	1740	2	of	of	IN
cord-015021-pol2qm74	1740	3	the	the	DT
cord-015021-pol2qm74	1740	4	prolnflammatory	prolnflammatory	NNP
cord-015021-pol2qm74	1740	5	cytokine	cytokine	NN
cord-015021-pol2qm74	1740	6	cascade	cascade	NN
cord-015021-pol2qm74	1740	7	following	follow	VBG
cord-015021-pol2qm74	1740	8	injury	injury	NN
cord-015021-pol2qm74	1740	9	that	that	WDT
cord-015021-pol2qm74	1740	10	has	have	VBZ
cord-015021-pol2qm74	1740	11	been	be	VBN
cord-015021-pol2qm74	1740	12	recognized	recognize	VBN
cord-015021-pol2qm74	1740	13	as	as	RB
cord-015021-pol2qm74	1740	14	significant	significant	JJ
cord-015021-pol2qm74	1740	15	in	in	IN
cord-015021-pol2qm74	1740	16	the	the	DT
cord-015021-pol2qm74	1740	17	process	process	NN
cord-015021-pol2qm74	1740	18	which	which	WDT
cord-015021-pol2qm74	1740	19	often	often	RB
cord-015021-pol2qm74	1740	20	leads	lead	VBZ
cord-015021-pol2qm74	1740	21	to	to	IN
cord-015021-pol2qm74	1740	22	multiple	multiple	JJ
cord-015021-pol2qm74	1740	23	o;gan	o;gan	NNP
cord-015021-pol2qm74	1740	24	failure	failure	NN
cord-015021-pol2qm74	1740	25	,	,	,
cord-015021-pol2qm74	1740	26	The	the	DT
cord-015021-pol2qm74	1740	27	immunosuppresslon	immunosuppresslon	NN
cord-015021-pol2qm74	1740	28	which	which	WDT
cord-015021-pol2qm74	1740	29	occurs	occur	VBZ
cord-015021-pol2qm74	1740	30	following	follow	VBG
cord-015021-pol2qm74	1740	31	major	major	JJ
cord-015021-pol2qm74	1740	32	thermal	thermal	JJ
cord-015021-pol2qm74	1740	33	Injury	injury	NN
cord-015021-pol2qm74	1740	34	may	may	MD
cord-015021-pol2qm74	1740	35	predispose	predispose	VB
cord-015021-pol2qm74	1740	36	these	these	DT
cord-015021-pol2qm74	1740	37	individuals	individual	NNS
cord-015021-pol2qm74	1740	38	to	to	IN
cord-015021-pol2qm74	1740	39	infection	infection	NN
cord-015021-pol2qm74	1740	40	and	and	CC
cord-015021-pol2qm74	1740	41	sepsis	sepsis	NN
cord-015021-pol2qm74	1740	42	,	,	,
cord-015021-pol2qm74	1740	43	which	which	WDT
cord-015021-pol2qm74	1740	44	remain	remain	VBP
cord-015021-pol2qm74	1740	45	a	a	DT
cord-015021-pol2qm74	1740	46	significant	significant	JJ
cord-015021-pol2qm74	1740	47	cause	cause	NN
cord-015021-pol2qm74	1740	48	of	of	IN
cord-015021-pol2qm74	1740	49	morbidity	morbidity	NN
cord-015021-pol2qm74	1740	50	and	and	CC
cord-015021-pol2qm74	1740	51	mortality	mortality	NN
cord-015021-pol2qm74	1740	52	.	.	.
cord-015021-pol2qm74	1741	1	Included	include	VBN
cord-015021-pol2qm74	1741	2	among	among	IN
cord-015021-pol2qm74	1741	3	the	the	DT
cord-015021-pol2qm74	1741	4	many	many	JJ
cord-015021-pol2qm74	1741	5	Immune	immune	JJ
cord-015021-pol2qm74	1741	6	aheratlons	aheratlon	NNS
cord-015021-pol2qm74	1741	7	are	be	VBP
cord-015021-pol2qm74	1741	8	the	the	DT
cord-015021-pol2qm74	1741	9	p2	p2	NNP
cord-015021-pol2qm74	1741	10	Integrln	Integrln	NNP
cord-015021-pol2qm74	1741	11	(	(	-LRB-
cord-015021-pol2qm74	1741	12	CDlla	CDlla	NNP
cord-015021-pol2qm74	1741	13	,	,	,
cord-015021-pol2qm74	1741	14	b	b	NN
cord-015021-pol2qm74	1741	15	,	,	,
cord-015021-pol2qm74	1741	16	c	c	NNP
cord-015021-pol2qm74	1741	17	/	/	SYM
cord-015021-pol2qm74	1741	18	CD18	CD18	NNP
cord-015021-pol2qm74	1741	19	)	)	-RRB-
cord-015021-pol2qm74	1741	20	dependent	dependent	JJ
cord-015021-pol2qm74	1741	21	activities	activity	NNS
cord-015021-pol2qm74	1741	22	of	of	IN
cord-015021-pol2qm74	1741	23	adhesion	adhesion	NN
cord-015021-pol2qm74	1741	24	,	,	,
cord-015021-pol2qm74	1741	25	chemotaxls	chemotaxls	NNP
cord-015021-pol2qm74	1741	26	,	,	,
cord-015021-pol2qm74	1741	27	diapodesls	diapodesls	NN
cord-015021-pol2qm74	1741	28	,	,	,
cord-015021-pol2qm74	1741	29	and	and	CC
cord-015021-pol2qm74	1741	30	phagocytosls	phagocytosl	NNS
cord-015021-pol2qm74	1741	31	.	.	.
cord-015021-pol2qm74	1742	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	1742	2	Investigations	investigation	NNS
cord-015021-pol2qm74	1742	3	indicate	indicate	VBP
cord-015021-pol2qm74	1742	4	that	that	IN
cord-015021-pol2qm74	1742	5	,	,	,
cord-015021-pol2qm74	1742	6	following	follow	VBG
cord-015021-pol2qm74	1742	7	major	major	JJ
cord-015021-pol2qm74	1742	8	thermal	thermal	JJ
cord-015021-pol2qm74	1742	9	injuries	injury	NNS
cord-015021-pol2qm74	1742	10	,	,	,
cord-015021-pol2qm74	1742	11	the	the	DT
cord-015021-pol2qm74	1742	12	expression	expression	NN
cord-015021-pol2qm74	1742	13	of	of	IN
cord-015021-pol2qm74	1742	14	the	the	DT
cord-015021-pol2qm74	1742	15	[	[	-LRB-
cord-015021-pol2qm74	1742	16	~2	~2	NNP
cord-015021-pol2qm74	1742	17	Integrlns	Integrlns	NNP
cord-015021-pol2qm74	1742	18	,	,	,
cord-015021-pol2qm74	1742	19	but	but	CC
cord-015021-pol2qm74	1742	20	not	not	RB
cord-015021-pol2qm74	1742	21	CD14	CD14	NNP
cord-015021-pol2qm74	1742	22	,	,	,
cord-015021-pol2qm74	1742	23	is	be	VBZ
cord-015021-pol2qm74	1742	24	significantly	significantly	RB
cord-015021-pol2qm74	1742	25	decreased	decrease	VBN
cord-015021-pol2qm74	1742	26	on	on	IN
cord-015021-pol2qm74	1742	27	neutrophlls	neutrophll	NNS
cord-015021-pol2qm74	1742	28	(	(	-LRB-
cord-015021-pol2qm74	1742	29	PMNs	PMNs	NNP
cord-015021-pol2qm74	1742	30	)	)	-RRB-
cord-015021-pol2qm74	1742	31	.	.	.
cord-015021-pol2qm74	1743	1	It	-PRON-	PRP
cord-015021-pol2qm74	1743	2	remains	remain	VBZ
cord-015021-pol2qm74	1743	3	unclear	unclear	JJ
cord-015021-pol2qm74	1743	4	if	if	IN
cord-015021-pol2qm74	1743	5	PMNs	pmn	NNS
cord-015021-pol2qm74	1743	6	from	from	IN
cord-015021-pol2qm74	1743	7	thermally	thermally	RB
cord-015021-pol2qm74	1743	8	Injured	injure	VBN
cord-015021-pol2qm74	1743	9	patients	patient	NNS
cord-015021-pol2qm74	1743	10	respond	respond	VBP
cord-015021-pol2qm74	1743	11	normally	normally	RB
cord-015021-pol2qm74	1743	12	to	to	IN
cord-015021-pol2qm74	1743	13	LPS	LPS	NNP
cord-015021-pol2qm74	1743	14	,	,	,
cord-015021-pol2qm74	1743	15	The	the	DT
cord-015021-pol2qm74	1743	16	effects	effect	NNS
cord-015021-pol2qm74	1743	17	of	of	IN
cord-015021-pol2qm74	1743	18	treatment	treatment	NN
cord-015021-pol2qm74	1743	19	in	in	IN
cord-015021-pol2qm74	1743	20	vitro	vitro	FW
cord-015021-pol2qm74	1743	21	with	with	IN
cord-015021-pol2qm74	1743	22	LPS	LPS	NNP
cord-015021-pol2qm74	1743	23	and	and	CC
cord-015021-pol2qm74	1743	24	f	f	NNP
cord-015021-pol2qm74	1743	25	-	-	HYPH
cord-015021-pol2qm74	1743	26	met	meet	VBN
cord-015021-pol2qm74	1743	27	-	-	HYPH
cord-015021-pol2qm74	1743	28	leu	leu	NN
cord-015021-pol2qm74	1743	29	-	-	HYPH
cord-015021-pol2qm74	1743	30	phe	phe	NNP
cord-015021-pol2qm74	1743	31	(	(	-LRB-
cord-015021-pol2qm74	1743	32	fMLP	fMLP	NNP
cord-015021-pol2qm74	1743	33	)	)	-RRB-
cord-015021-pol2qm74	1743	34	on	on	IN
cord-015021-pol2qm74	1743	35	the	the	DT
cord-015021-pol2qm74	1743	36	expression	expression	NN
cord-015021-pol2qm74	1743	37	of	of	IN
cord-015021-pol2qm74	1743	38	CDtlb	CDtlb	NNP
cord-015021-pol2qm74	1743	39	was	be	VBD
cord-015021-pol2qm74	1743	40	examlned	examlne	VBN
cord-015021-pol2qm74	1743	41	on	on	IN
cord-015021-pol2qm74	1743	42	PMNs	pmn	NNS
cord-015021-pol2qm74	1743	43	from	from	IN
cord-015021-pol2qm74	1743	44	the	the	DT
cord-015021-pol2qm74	1743	45	peripheral	peripheral	JJ
cord-015021-pol2qm74	1743	46	blood	blood	NN
cord-015021-pol2qm74	1743	47	of	of	IN
cord-015021-pol2qm74	1743	48	healthy	healthy	JJ
cord-015021-pol2qm74	1743	49	volunteers	volunteer	NNS
cord-015021-pol2qm74	1743	50	and	and	CC
cord-015021-pol2qm74	1743	51	non	non	JJ
cord-015021-pol2qm74	1743	52	-	-	JJ
cord-015021-pol2qm74	1743	53	septic	septic	JJ
cord-015021-pol2qm74	1743	54	burn	burn	NN
cord-015021-pol2qm74	1743	55	patients	patient	NNS
cord-015021-pol2qm74	1743	56	(	(	-LRB-
cord-015021-pol2qm74	1743	57	>	>	NFP
cord-015021-pol2qm74	1743	58	30~	30~	CD
cord-015021-pol2qm74	1743	59	;	;	:
cord-015021-pol2qm74	1743	60	total	total	JJ
cord-015021-pol2qm74	1743	61	body	body	NN
cord-015021-pol2qm74	1743	62	surface	surface	NN
cord-015021-pol2qm74	1743	63	area	area	NN
cord-015021-pol2qm74	1743	64	,	,	,
cord-015021-pol2qm74	1743	65	>	>	XX
cord-015021-pol2qm74	1744	1	lS~	lS~	NNP
cord-015021-pol2qm74	1744	2	full	full	JJ
cord-015021-pol2qm74	1744	3	thickness	thickness	NN
cord-015021-pol2qm74	1744	4	)	)	-RRB-
cord-015021-pol2qm74	1745	1	,	,	,
cord-015021-pol2qm74	1745	2	The	the	DT
cord-015021-pol2qm74	1745	3	PMNs	pmn	NNS
cord-015021-pol2qm74	1745	4	were	be	VBD
cord-015021-pol2qm74	1745	5	Incubated	incubate	VBN
cord-015021-pol2qm74	1745	6	with	with	IN
cord-015021-pol2qm74	1745	7	LPS	LPS	NNP
cord-015021-pol2qm74	1745	8	(	(	-LRB-
cord-015021-pol2qm74	1745	9	]	]	-RRB-
cord-015021-pol2qm74	1745	10	ng-10p.g	ng-10p.g	JJ
cord-015021-pol2qm74	1745	11	/	/	SYM
cord-015021-pol2qm74	1745	12	ml	ml	NN
cord-015021-pol2qm74	1745	13	)	)	-RRB-
cord-015021-pol2qm74	1745	14	or	or	CC
cord-015021-pol2qm74	1745	15	f'MLP	f'MLP	NNP
cord-015021-pol2qm74	1745	16	(	(	-LRB-
cord-015021-pol2qm74	1745	17	10	10	CD
cord-015021-pol2qm74	1745	18	"	"	``
cord-015021-pol2qm74	1745	19	1	1	CD
cord-015021-pol2qm74	1745	20	1	1	CD
cord-015021-pol2qm74	1745	21	to	to	IN
cord-015021-pol2qm74	1745	22	10"6	10"6	CD
cord-015021-pol2qm74	1745	23	M	M	NNP
cord-015021-pol2qm74	1745	24	)	)	-RRB-
cord-015021-pol2qm74	1745	25	et	et	FW
cord-015021-pol2qm74	1745	26	37oc	37oc	NN
cord-015021-pol2qm74	1745	27	for	for	IN
cord-015021-pol2qm74	1745	28	30	30	CD
cord-015021-pol2qm74	1745	29	mln	mln	NNS
cord-015021-pol2qm74	1745	30	,	,	,
cord-015021-pol2qm74	1745	31	In	in	IN
cord-015021-pol2qm74	1745	32	1~	1~	CD
cord-015021-pol2qm74	1745	33	;	;	:
cord-015021-pol2qm74	1745	34	human	human	JJ
cord-015021-pol2qm74	1745	35	AB	AB	NNP
cord-015021-pol2qm74	1745	36	serum	serum	NN
cord-015021-pol2qm74	1745	37	,	,	,
cord-015021-pol2qm74	1745	38	The	the	DT
cord-015021-pol2qm74	1745	39	expression	expression	NN
cord-015021-pol2qm74	1745	40	of	of	IN
cord-015021-pol2qm74	1745	41	the	the	DT
cord-015021-pol2qm74	1745	42	132	132	CD
cord-015021-pol2qm74	1745	43	]	]	-RRB-
cord-015021-pol2qm74	1745	44	ntegrins	ntegrin	NNS
cord-015021-pol2qm74	1745	45	was	be	VBD
cord-015021-pol2qm74	1745	46	detected	detect	VBN
cord-015021-pol2qm74	1745	47	using	use	VBG
cord-015021-pol2qm74	1745	48	monoclonat	monoclonat	NNP
cord-015021-pol2qm74	1745	49	antibodies	antibody	NNS
cord-015021-pol2qm74	1745	50	and	and	CC
cord-015021-pol2qm74	1745	51	flow	flow	NN
cord-015021-pol2qm74	1745	52	cytometry	cytometry	NN
cord-015021-pol2qm74	1745	53	.	.	.
cord-015021-pol2qm74	1746	1	LPS	LPS	NNP
cord-015021-pol2qm74	1746	2	and	and	CC
cord-015021-pol2qm74	1746	3	f'MLP	f'MLP	NNP
cord-015021-pol2qm74	1746	4	resulted	result	VBD
cord-015021-pol2qm74	1746	5	In	in	IN
cord-015021-pol2qm74	1746	6	a	a	DT
cord-015021-pol2qm74	1746	7	slight	slight	JJ
cord-015021-pol2qm74	1746	8	Increase	increase	NN
cord-015021-pol2qm74	1746	9	(	(	-LRB-
cord-015021-pol2qm74	1746	10	3	3	CD
cord-015021-pol2qm74	1746	11	fold	fold	VB
cord-015021-pol2qm74	1746	12	)	)	-RRB-
cord-015021-pol2qm74	1746	13	In	in	IN
cord-015021-pol2qm74	1746	14	the	the	DT
cord-015021-pol2qm74	1746	15	expression	expression	NN
cord-015021-pol2qm74	1746	16	of	of	IN
cord-015021-pol2qm74	1746	17	CD11b	CD11b	NNS
cord-015021-pol2qm74	1746	18	on	on	IN
cord-015021-pol2qm74	1746	19	PMNS	PMNS	NNP
cord-015021-pol2qm74	1746	20	from	from	IN
cord-015021-pol2qm74	1746	21	burned	burn	VBN
cord-015021-pol2qm74	1746	22	patients	patient	NNS
cord-015021-pol2qm74	1746	23	compared	compare	VBN
cord-015021-pol2qm74	1746	24	to	to	IN
cord-015021-pol2qm74	1746	25	an	an	DT
cord-015021-pol2qm74	1746	26	8	8	CD
cord-015021-pol2qm74	1746	27	and	and	CC
cord-015021-pol2qm74	1746	28	14	14	CD
cord-015021-pol2qm74	1746	29	fold	fold	JJ
cord-015021-pol2qm74	1746	30	increase	increase	NN
cord-015021-pol2qm74	1746	31	,	,	,
cord-015021-pol2qm74	1746	32	respectively	respectively	RB
cord-015021-pol2qm74	1746	33	,	,	,
cord-015021-pol2qm74	1746	34	on	on	IN
cord-015021-pol2qm74	1746	35	PMNs	pmn	NNS
cord-015021-pol2qm74	1746	36	from	from	IN
cord-015021-pol2qm74	1746	37	healthy	healthy	JJ
cord-015021-pol2qm74	1746	38	individuals	individual	NNS
cord-015021-pol2qm74	1746	39	.	.	.
cord-015021-pol2qm74	1747	1	This	this	DT
cord-015021-pol2qm74	1747	2	Inability	Inability	NNP
cord-015021-pol2qm74	1747	3	of	of	IN
cord-015021-pol2qm74	1747	4	LPS	LPS	NNP
cord-015021-pol2qm74	1747	5	or	or	CC
cord-015021-pol2qm74	1747	6	fMLP	fmlp	NN
cord-015021-pol2qm74	1747	7	to	to	TO
cord-015021-pol2qm74	1747	8	increase	increase	VB
cord-015021-pol2qm74	1747	9	CD11	CD11	NNP
cord-015021-pol2qm74	1747	10	b	b	CD
cord-015021-pol2qm74	1747	11	expression	expression	NN
cord-015021-pol2qm74	1747	12	was	be	VBD
cord-015021-pol2qm74	1747	13	not	not	RB
cord-015021-pol2qm74	1747	14	due	due	JJ
cord-015021-pol2qm74	1747	15	to	to	IN
cord-015021-pol2qm74	1747	16	the	the	DT
cord-015021-pol2qm74	1747	17	amount	amount	NN
cord-015021-pol2qm74	1747	18	of	of	IN
cord-015021-pol2qm74	1747	19	LPS	lp	NNS
cord-015021-pol2qm74	1747	20	bound	bind	VBN
cord-015021-pol2qm74	1747	21	to	to	IN
cord-015021-pol2qm74	1747	22	the	the	DT
cord-015021-pol2qm74	1747	23	two	two	CD
cord-015021-pol2qm74	1747	24	cell	cell	NN
cord-015021-pol2qm74	1747	25	populations	population	NNS
cord-015021-pol2qm74	1747	26	.	.	.
cord-015021-pol2qm74	1748	1	Because	because	IN
cord-015021-pol2qm74	1748	2	the	the	DT
cord-015021-pol2qm74	1748	3	same	same	JJ
cord-015021-pol2qm74	1748	4	defect	defect	NN
cord-015021-pol2qm74	1748	5	Is	be	VBZ
cord-015021-pol2qm74	1748	6	seen	see	VBN
cord-015021-pol2qm74	1748	7	after	after	IN
cord-015021-pol2qm74	1748	8	either	either	DT
cord-015021-pol2qm74	1748	9	LPS	LPS	NNP
cord-015021-pol2qm74	1748	10	or	or	CC
cord-015021-pol2qm74	1748	11	fMLP	fmlp	JJ
cord-015021-pol2qm74	1748	12	stimulation	stimulation	NN
cord-015021-pol2qm74	1748	13	,	,	,
cord-015021-pol2qm74	1748	14	It	-PRON-	PRP
cord-015021-pol2qm74	1748	15	Is	be	VBZ
cord-015021-pol2qm74	1748	16	speculated	speculate	VBN
cord-015021-pol2qm74	1748	17	that	that	IN
cord-015021-pol2qm74	1748	18	the	the	DT
cord-015021-pol2qm74	1748	19	defect	defect	NN
cord-015021-pol2qm74	1748	20	must	must	MD
cord-015021-pol2qm74	1748	21	be	be	VB
cord-015021-pol2qm74	1748	22	in	in	IN
cord-015021-pol2qm74	1748	23	the	the	DT
cord-015021-pol2qm74	1748	24	amount	amount	NN
cord-015021-pol2qm74	1748	25	of	of	IN
cord-015021-pol2qm74	1748	26	preformed	preformed	JJ
cord-015021-pol2qm74	1748	27	CD1	CD1	NNP
cord-015021-pol2qm74	1748	28	]	]	-RRB-
cord-015021-pol2qm74	1748	29	b	b	NN
cord-015021-pol2qm74	1748	30	or	or	CC
cord-015021-pol2qm74	1748	31	Its	-PRON-	PRP$
cord-015021-pol2qm74	1748	32	transport	transport	NN
cord-015021-pol2qm74	1748	33	to	to	IN
cord-015021-pol2qm74	1748	34	the	the	DT
cord-015021-pol2qm74	1748	35	plasma	plasma	NN
cord-015021-pol2qm74	1748	36	membrane	membrane	NN
cord-015021-pol2qm74	1748	37	.	.	.
cord-015021-pol2qm74	1749	1	Platelet	platelet	NN
cord-015021-pol2qm74	1749	2	-	-	HYPH
cord-015021-pol2qm74	1749	3	activating	activate	VBG
cord-015021-pol2qm74	1749	4	factor	factor	NN
cord-015021-pol2qm74	1749	5	(	(	-LRB-
cord-015021-pol2qm74	1749	6	PAF	PAF	NNP
cord-015021-pol2qm74	1749	7	)	)	-RRB-
cord-015021-pol2qm74	1749	8	and	and	CC
cord-015021-pol2qm74	1749	9	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1749	10	have	have	VBP
cord-015021-pol2qm74	1749	11	been	be	VBN
cord-015021-pol2qm74	1749	12	implicated	implicate	VBN
cord-015021-pol2qm74	1749	13	in	in	IN
cord-015021-pol2qm74	1749	14	the	the	DT
cord-015021-pol2qm74	1749	15	patbophysiology	patbophysiology	NN
cord-015021-pol2qm74	1749	16	of	of	IN
cord-015021-pol2qm74	1749	17	ischemia	ischemia	NN
cord-015021-pol2qm74	1749	18	-	-	HYPH
cord-015021-pol2qm74	1749	19	repeffusion	repeffusion	NN
cord-015021-pol2qm74	1749	20	injury	injury	NN
cord-015021-pol2qm74	1749	21	,	,	,
cord-015021-pol2qm74	1749	22	In	in	IN
cord-015021-pol2qm74	1749	23	addition	addition	NN
cord-015021-pol2qm74	1749	24	,	,	,
cord-015021-pol2qm74	1749	25	PAF	PAF	NNP
cord-015021-pol2qm74	1749	26	stimulates	stimulate	VBZ
cord-015021-pol2qm74	1749	27	neutrophi	neutrophi	RB
cord-015021-pol2qm74	1749	28	[	[	-LRB-
cord-015021-pol2qm74	1749	29	(	(	-LRB-
cord-015021-pol2qm74	1749	30	PMN	pmn	NN
cord-015021-pol2qm74	1749	31	)	)	-RRB-
cord-015021-pol2qm74	1749	32	oxidative	oxidative	JJ
cord-015021-pol2qm74	1749	33	metabolism	metabolism	NN
cord-015021-pol2qm74	1749	34	in	in	IN
cord-015021-pol2qm74	1749	35	vitro	vitro	FW
cord-015021-pol2qm74	1749	36	.	.	.
cord-015021-pol2qm74	1750	1	The	the	DT
cord-015021-pol2qm74	1750	2	present	present	JJ
cord-015021-pol2qm74	1750	3	study	study	NN
cord-015021-pol2qm74	1750	4	examined	examine	VBD
cord-015021-pol2qm74	1750	5	the	the	DT
cord-015021-pol2qm74	1750	6	potential	potential	JJ
cord-015021-pol2qm74	1750	7	role	role	NN
cord-015021-pol2qm74	1750	8	of	of	IN
cord-015021-pol2qm74	1750	9	PAF	PAF	NNP
cord-015021-pol2qm74	1750	10	in	in	IN
cord-015021-pol2qm74	1750	11	repeffusion	repeffusion	NN
cord-015021-pol2qm74	1750	12	injury	injury	NN
cord-015021-pol2qm74	1750	13	in	in	IN
cord-015021-pol2qm74	1750	14	an	an	DT
cord-015021-pol2qm74	1750	15	in	in	IN
cord-015021-pol2qm74	1750	16	viva	viva	FW
cord-015021-pol2qm74	1750	17	rabbit	rabbit	NN
cord-015021-pol2qm74	1750	18	model	model	NN
cord-015021-pol2qm74	1750	19	.	.	.
cord-015021-pol2qm74	1751	1	Eight	eight	CD
cord-015021-pol2qm74	1751	2	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	1751	3	rabbi~	rabbi~	NNS
cord-015021-pol2qm74	1752	1	s	s	POS
cord-015021-pol2qm74	1752	2	underwent	undergo	VBD
cord-015021-pol2qm74	1752	3	retroperitoneal	retroperitoneal	JJ
cord-015021-pol2qm74	1752	4	exposure	exposure	NN
cord-015021-pol2qm74	1752	5	of	of	IN
cord-015021-pol2qm74	1752	6	the	the	DT
cord-015021-pol2qm74	1752	7	infrarenal	infrarenal	JJ
cord-015021-pol2qm74	1752	8	abdominal	abdominal	NNP
cord-015021-pol2qm74	1752	9	aorta	aorta	NN
cord-015021-pol2qm74	1752	10	after	after	IN
cord-015021-pol2qm74	1752	11	percutaneous	percutaneous	JJ
cord-015021-pol2qm74	1752	12	insertion	insertion	NN
cord-015021-pol2qm74	1752	13	of	of	IN
cord-015021-pol2qm74	1752	14	a	a	DT
cord-015021-pol2qm74	1752	15	catheter	catheter	NN
cord-015021-pol2qm74	1752	16	through	through	IN
cord-015021-pol2qm74	1752	17	the	the	DT
cord-015021-pol2qm74	1752	18	jugular	jugular	NN
cord-015021-pol2qm74	1752	19	vein	vein	NN
cord-015021-pol2qm74	1752	20	into	into	IN
cord-015021-pol2qm74	1752	21	the	the	DT
cord-015021-pol2qm74	1752	22	infrahepatic	infrahepatic	JJ
cord-015021-pol2qm74	1752	23	inferior	inferior	JJ
cord-015021-pol2qm74	1752	24	vena	vena	FW
cord-015021-pol2qm74	1752	25	cava	cava	NN
cord-015021-pol2qm74	1752	26	.	.	.
cord-015021-pol2qm74	1753	1	Doppler	Doppler	NNP
cord-015021-pol2qm74	1753	2	flow	flow	NN
cord-015021-pol2qm74	1753	3	probes	probe	NNS
cord-015021-pol2qm74	1753	4	were	be	VBD
cord-015021-pol2qm74	1753	5	placed	place	VBN
cord-015021-pol2qm74	1753	6	around	around	IN
cord-015021-pol2qm74	1753	7	the	the	DT
cord-015021-pol2qm74	1753	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	1753	9	aorta	aorta	NN
cord-015021-pol2qm74	1753	10	and	and	CC
cord-015021-pol2qm74	1753	11	the	the	DT
cord-015021-pol2qm74	1753	12	right	right	JJ
cord-015021-pol2qm74	1753	13	common	common	JJ
cord-015021-pol2qm74	1753	14	femoral	femoral	JJ
cord-015021-pol2qm74	1753	15	artery	artery	NN
cord-015021-pol2qm74	1753	16	to	to	TO
cord-015021-pol2qm74	1753	17	assess	assess	VB
cord-015021-pol2qm74	1753	18	flow	flow	NN
cord-015021-pol2qm74	1753	19	through	through	IN
cord-015021-pol2qm74	1753	20	these	these	DT
cord-015021-pol2qm74	1753	21	vessels	vessel	NNS
cord-015021-pol2qm74	1753	22	.	.	.
cord-015021-pol2qm74	1754	1	An	an	DT
cord-015021-pol2qm74	1754	2	occlusive	occlusive	JJ
cord-015021-pol2qm74	1754	3	ligature	ligature	NN
cord-015021-pol2qm74	1754	4	was	be	VBD
cord-015021-pol2qm74	1754	5	placed	place	VBN
cord-015021-pol2qm74	1754	6	around	around	IN
cord-015021-pol2qm74	1754	7	the	the	DT
cord-015021-pol2qm74	1754	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	1754	9	aorta	aorta	NN
cord-015021-pol2qm74	1754	10	(	(	-LRB-
cord-015021-pol2qm74	1754	11	superior	superior	JJ
cord-015021-pol2qm74	1754	12	to	to	IN
cord-015021-pol2qm74	1754	13	the	the	DT
cord-015021-pol2qm74	1754	14	flow	flow	NN
cord-015021-pol2qm74	1754	15	probe	probe	NN
cord-015021-pol2qm74	1754	16	)	)	-RRB-
cord-015021-pol2qm74	1754	17	at	at	IN
cord-015021-pol2qm74	1754	18	t	t	NN
cord-015021-pol2qm74	1754	19	=	=	SYM
cord-015021-pol2qm74	1754	20	0	0	CD
cord-015021-pol2qm74	1754	21	and	and	CC
cord-015021-pol2qm74	1754	22	total	total	JJ
cord-015021-pol2qm74	1754	23	occlusion	occlusion	NN
cord-015021-pol2qm74	1754	24	of	of	IN
cord-015021-pol2qm74	1754	25	blood	blood	NN
cord-015021-pol2qm74	1754	26	flow	flow	NN
cord-015021-pol2qm74	1754	27	to	to	IN
cord-015021-pol2qm74	1754	28	the	the	DT
cord-015021-pol2qm74	1754	29	lower	low	JJR
cord-015021-pol2qm74	1754	30	extremities	extremity	NNS
cord-015021-pol2qm74	1754	31	was	be	VBD
cord-015021-pol2qm74	1754	32	maintained	maintain	VBN
cord-015021-pol2qm74	1754	33	for	for	IN
cord-015021-pol2qm74	1754	34	g0	g0	NN
cord-015021-pol2qm74	1754	35	mins	min	NNS
cord-015021-pol2qm74	1754	36	.	.	.
cord-015021-pol2qm74	1755	1	,	,	,
cord-015021-pol2qm74	1755	2	after	after	IN
cord-015021-pol2qm74	1755	3	which	which	WDT
cord-015021-pol2qm74	1755	4	the	the	DT
cord-015021-pol2qm74	1755	5	ligature	ligature	NN
cord-015021-pol2qm74	1755	6	was	be	VBD
cord-015021-pol2qm74	1755	7	released	release	VBN
cord-015021-pol2qm74	1755	8	allowing	allow	VBG
cord-015021-pol2qm74	1755	9	for	for	IN
cord-015021-pol2qm74	1755	10	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1755	11	of	of	IN
cord-015021-pol2qm74	1755	12	the	the	DT
cord-015021-pol2qm74	1755	13	ischemic	ischemic	JJ
cord-015021-pol2qm74	1755	14	lower	low	JJR
cord-015021-pol2qm74	1755	15	limbs	limb	NNS
cord-015021-pol2qm74	1755	16	.	.	.
cord-015021-pol2qm74	1756	1	Effluent	effluent	JJ
cord-015021-pol2qm74	1756	2	blood	blood	NN
cord-015021-pol2qm74	1756	3	from	from	IN
cord-015021-pol2qm74	1756	4	the	the	DT
cord-015021-pol2qm74	1756	5	ischemic	ischemic	JJ
cord-015021-pol2qm74	1756	6	hind	hind	NN
cord-015021-pol2qm74	1756	7	-	-	HYPH
cord-015021-pol2qm74	1756	8	limbs	limb	NNS
cord-015021-pol2qm74	1756	9	was	be	VBD
cord-015021-pol2qm74	1756	10	collected	collect	VBN
cord-015021-pol2qm74	1756	11	through	through	IN
cord-015021-pol2qm74	1756	12	the	the	DT
cord-015021-pol2qm74	1756	13	IVC	IVC	NNP
cord-015021-pol2qm74	1756	14	catheter	catheter	NN
cord-015021-pol2qm74	1756	15	at	at	IN
cord-015021-pol2qm74	1756	16	the	the	DT
cord-015021-pol2qm74	1756	17	times	time	NNS
cord-015021-pol2qm74	1756	18	indicated	indicate	VBN
cord-015021-pol2qm74	1756	19	below	below	RB
cord-015021-pol2qm74	1756	20	and	and	CC
cord-015021-pol2qm74	1756	21	assayed	assay	VBN
cord-015021-pol2qm74	1756	22	for	for	IN
cord-015021-pol2qm74	1756	23	PAF	PAF	NNP
cord-015021-pol2qm74	1756	24	by	by	IN
cord-015021-pol2qm74	1756	25	a	a	DT
cord-015021-pol2qm74	1756	26	direct	direct	JJ
cord-015021-pol2qm74	1756	27	radioimmunoassay	radioimmunoassay	NN
cord-015021-pol2qm74	1756	28	.	.	.
cord-015021-pol2qm74	1757	1	In	in	IN
cord-015021-pol2qm74	1757	2	addition	addition	NN
cord-015021-pol2qm74	1757	3	,	,	,
cord-015021-pol2qm74	1757	4	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1757	5	H202	h202	NN
cord-015021-pol2qm74	1757	6	production	production	NN
cord-015021-pol2qm74	1757	7	was	be	VBD
cord-015021-pol2qm74	1757	8	determined	determine	VBN
cord-015021-pol2qm74	1757	9	by	by	IN
cord-015021-pol2qm74	1757	10	a	a	DT
cord-015021-pol2qm74	1757	11	previously	previously	RB
cord-015021-pol2qm74	1757	12	described	describe	VBN
cord-015021-pol2qm74	1757	13	2'7'-dichlorofluorescein	2'7'-dichlorofluorescein	CD
cord-015021-pol2qm74	1757	14	flowcytametric	flowcytametric	JJ
cord-015021-pol2qm74	1757	15	assay	assay	NN
cord-015021-pol2qm74	1757	16	.	.	.
cord-015021-pol2qm74	1758	1	185	185	CD
cord-015021-pol2qm74	1758	2	_	_	NN
cord-015021-pol2qm74	1758	3	+	+	SYM
cord-015021-pol2qm74	1758	4	53	53	CD
cord-015021-pol2qm74	1758	5	amean	amean	NNP
cord-015021-pol2qm74	1759	1	_	_	NNP
cord-015021-pol2qm74	1759	2	+	+	CC
cord-015021-pol2qm74	1760	1	s.e.m	s.e.m	NNP
cord-015021-pol2qm74	1760	2	,	,	,
cord-015021-pol2qm74	1760	3	pg	pg	NNP
cord-015021-pol2qm74	1760	4	/	/	SYM
cord-015021-pol2qm74	1760	5	ml	ml	IN
cord-015021-pol2qm74	1760	6	blood	blood	NN
cord-015021-pol2qm74	1760	7	;	;	:
cord-015021-pol2qm74	1760	8	brelative	brelative	NNP
cord-015021-pol2qm74	1760	9	fluoresenee	fluoresenee	NNP
cord-015021-pol2qm74	1760	10	(	(	-LRB-
cord-015021-pol2qm74	1760	11	%	%	NN
cord-015021-pol2qm74	1760	12	of	of	IN
cord-015021-pol2qm74	1760	13	baseline	baseline	NN
cord-015021-pol2qm74	1760	14	)	)	-RRB-
cord-015021-pol2qm74	1760	15	;	;	:
cord-015021-pol2qm74	1760	16	Caortic	caortic	JJ
cord-015021-pol2qm74	1760	17	and	and	CC
cord-015021-pol2qm74	1760	18	femoral	femoral	JJ
cord-015021-pol2qm74	1760	19	artery	artery	NN
cord-015021-pol2qm74	1760	20	flow	flow	NN
cord-015021-pol2qm74	1760	21	(	(	-LRB-
cord-015021-pol2qm74	1760	22	%	%	NN
cord-015021-pol2qm74	1760	23	of	of	IN
cord-015021-pol2qm74	1760	24	baseline	baseline	NN
cord-015021-pol2qm74	1760	25	)	)	-RRB-
cord-015021-pol2qm74	1760	26	;	;	:
cord-015021-pol2qm74	1761	1	*	*	NFP
cord-015021-pol2qm74	1761	2	p	p	XX
cord-015021-pol2qm74	1761	3	<	<	XX
cord-015021-pol2qm74	1761	4	0.01	0.01	CD
cord-015021-pol2qm74	1761	5	vs.	vs.	IN
cord-015021-pol2qm74	1761	6	baseline	baseline	NN
cord-015021-pol2qm74	1761	7	;	;	:
cord-015021-pol2qm74	1761	8	1"p	1"p	CD
cord-015021-pol2qm74	1761	9	<	<	XX
cord-015021-pol2qm74	1761	10	0.05	0.05	CD
cord-015021-pol2qm74	1761	11	vs.	vs.	IN
cord-015021-pol2qm74	1761	12	baseline	baseline	NN
cord-015021-pol2qm74	1761	13	.	.	.
cord-015021-pol2qm74	1762	1	A	a	DT
cord-015021-pol2qm74	1762	2	significant	significant	JJ
cord-015021-pol2qm74	1762	3	elevation	elevation	NN
cord-015021-pol2qm74	1762	4	of	of	IN
cord-015021-pol2qm74	1762	5	PAF	PAF	NNP
cord-015021-pol2qm74	1762	6	was	be	VBD
cord-015021-pol2qm74	1762	7	observed	observe	VBN
cord-015021-pol2qm74	1762	8	in	in	IN
cord-015021-pol2qm74	1762	9	ischemic	ischemic	JJ
cord-015021-pol2qm74	1762	10	hind	hind	JJ
cord-015021-pol2qm74	1762	11	-	-	HYPH
cord-015021-pol2qm74	1762	12	limb	limb	NN
cord-015021-pol2qm74	1762	13	effluent	effluent	NN
cord-015021-pol2qm74	1762	14	blood	blood	NN
cord-015021-pol2qm74	1762	15	at	at	IN
cord-015021-pol2qm74	1762	16	15	15	CD
cord-015021-pol2qm74	1762	17	min	min	NN
cord-015021-pol2qm74	1762	18	.	.	.
cord-015021-pol2qm74	1763	1	after	after	IN
cord-015021-pol2qm74	1763	2	release	release	NN
cord-015021-pol2qm74	1763	3	of	of	IN
cord-015021-pol2qm74	1763	4	the	the	DT
cord-015021-pol2qm74	1763	5	aortic	aortic	JJ
cord-015021-pol2qm74	1763	6	ligature	ligature	NN
cord-015021-pol2qm74	1763	7	during	during	IN
cord-015021-pol2qm74	1763	8	the	the	DT
cord-015021-pol2qm74	1763	9	repeffusion	repeffusion	NN
cord-015021-pol2qm74	1763	10	phase	phase	NN
cord-015021-pol2qm74	1763	11	,	,	,
cord-015021-pol2qm74	1763	12	as	as	IN
cord-015021-pol2qm74	1763	13	compared	compare	VBN
cord-015021-pol2qm74	1763	14	to	to	IN
cord-015021-pol2qm74	1763	15	baseline	baseline	JJ
cord-015021-pol2qm74	1763	16	levels	level	NNS
cord-015021-pol2qm74	1763	17	.	.	.
cord-015021-pol2qm74	1764	1	In	in	IN
cord-015021-pol2qm74	1764	2	addition	addition	NN
cord-015021-pol2qm74	1764	3	,	,	,
cord-015021-pol2qm74	1764	4	PMN	PMN	NNP
cord-015021-pol2qm74	1764	5	H20	H20	NNP
cord-015021-pol2qm74	1764	6	2	2	CD
cord-015021-pol2qm74	1764	7	production	production	NN
cord-015021-pol2qm74	1764	8	was	be	VBD
cord-015021-pol2qm74	1764	9	increased	increase	VBN
cord-015021-pol2qm74	1764	10	by	by	IN
cord-015021-pol2qm74	1764	11	2.3-fold	2.3-fold	CD
cord-015021-pol2qm74	1764	12	above	above	IN
cord-015021-pol2qm74	1764	13	baseline	baseline	JJ
cord-015021-pol2qm74	1764	14	values	value	NNS
cord-015021-pol2qm74	1764	15	by	by	IN
cord-015021-pol2qm74	1764	16	1	1	CD
cord-015021-pol2qm74	1764	17	hour	hour	NN
cord-015021-pol2qm74	1764	18	after	after	IN
cord-015021-pol2qm74	1764	19	ligature	ligature	NN
cord-015021-pol2qm74	1764	20	release	release	NN
cord-015021-pol2qm74	1764	21	during	during	IN
cord-015021-pol2qm74	1764	22	the	the	DT
cord-015021-pol2qm74	1764	23	reperfusion	reperfusion	NN
cord-015021-pol2qm74	1764	24	phase	phase	NN
cord-015021-pol2qm74	1764	25	.	.	.
cord-015021-pol2qm74	1765	1	Both	both	DT
cord-015021-pol2qm74	1765	2	of	of	IN
cord-015021-pol2qm74	1765	3	these	these	DT
cord-015021-pol2qm74	1765	4	elevations	elevation	NNS
cord-015021-pol2qm74	1765	5	were	be	VBD
cord-015021-pol2qm74	1765	6	transient	transient	JJ
cord-015021-pol2qm74	1765	7	and	and	CC
cord-015021-pol2qm74	1765	8	returned	return	VBD
cord-015021-pol2qm74	1765	9	toward	toward	IN
cord-015021-pol2qm74	1765	10	baseline	baseline	NN
cord-015021-pol2qm74	1765	11	by	by	IN
cord-015021-pol2qm74	1765	12	2	2	CD
cord-015021-pol2qm74	1765	13	hours	hour	NNS
cord-015021-pol2qm74	1765	14	post	post	NN
cord-015021-pol2qm74	1765	15	-	-	NN
cord-015021-pol2qm74	1765	16	isehemia	isehemia	JJ
cord-015021-pol2qm74	1765	17	.	.	.
cord-015021-pol2qm74	1766	1	Tatar	Tatar	NNP
cord-015021-pol2qm74	1766	2	occlusion	occlusion	NN
cord-015021-pol2qm74	1766	3	of	of	IN
cord-015021-pol2qm74	1766	4	hind	hind	JJ
cord-015021-pol2qm74	1766	5	-	-	HYPH
cord-015021-pol2qm74	1766	6	limb	limb	NN
cord-015021-pol2qm74	1766	7	flow	flow	NN
cord-015021-pol2qm74	1766	8	was	be	VBD
cord-015021-pol2qm74	1766	9	achieved	achieve	VBN
cord-015021-pol2qm74	1766	10	as	as	IN
cord-015021-pol2qm74	1766	11	evidenced	evidence	VBN
cord-015021-pol2qm74	1766	12	by	by	IN
cord-015021-pol2qm74	1766	13	the	the	DT
cord-015021-pol2qm74	1766	14	absence	absence	NN
cord-015021-pol2qm74	1766	15	of	of	IN
cord-015021-pol2qm74	1766	16	aortic	aortic	JJ
cord-015021-pol2qm74	1766	17	or	or	CC
cord-015021-pol2qm74	1766	18	femorat	femorat	NN
cord-015021-pol2qm74	1766	19	flow	flow	NN
cord-015021-pol2qm74	1766	20	at	at	IN
cord-015021-pol2qm74	1766	21	90	90	CD
cord-015021-pol2qm74	1766	22	rain	rain	NN
cord-015021-pol2qm74	1766	23	.	.	.
cord-015021-pol2qm74	1767	1	post	post	JJ
cord-015021-pol2qm74	1767	2	-	-	JJ
cord-015021-pol2qm74	1767	3	ischemia	ischemia	JJ
cord-015021-pol2qm74	1767	4	,	,	,
cord-015021-pol2qm74	1767	5	however	however	RB
cord-015021-pol2qm74	1767	6	after	after	IN
cord-015021-pol2qm74	1767	7	release	release	NN
cord-015021-pol2qm74	1767	8	01	01	CD
cord-015021-pol2qm74	1767	9	the	the	DT
cord-015021-pol2qm74	1767	10	ligature	ligature	NN
cord-015021-pol2qm74	1767	11	a	a	DT
cord-015021-pol2qm74	1767	12	significant	significant	JJ
cord-015021-pol2qm74	1767	13	reactive	reactive	JJ
cord-015021-pol2qm74	1767	14	hyperemia	hyperemia	NN
cord-015021-pol2qm74	1767	15	was	be	VBD
cord-015021-pol2qm74	1767	16	observed	observe	VBN
cord-015021-pol2qm74	1767	17	by	by	IN
cord-015021-pol2qm74	1767	18	15	15	CD
cord-015021-pol2qm74	1767	19	mln	mln	NNS
cord-015021-pol2qm74	1767	20	.	.	.
cord-015021-pol2qm74	1768	1	into	into	IN
cord-015021-pol2qm74	1768	2	the	the	DT
cord-015021-pol2qm74	1768	3	rapeffusion	rapeffusion	NN
cord-015021-pol2qm74	1768	4	phase	phase	NN
cord-015021-pol2qm74	1768	5	.	.	.
cord-015021-pol2qm74	1769	1	Histolog[c	histolog[c	NN
cord-015021-pol2qm74	1769	2	examination	examination	NN
cord-015021-pol2qm74	1769	3	of	of	IN
cord-015021-pol2qm74	1769	4	reper[used	reper[used	JJ
cord-015021-pol2qm74	1769	5	gastrocnemius	gastrocnemius	NN
cord-015021-pol2qm74	1769	6	muscle	muscle	NN
cord-015021-pol2qm74	1769	7	revealed	reveal	VBD
cord-015021-pol2qm74	1769	8	moderate	moderate	JJ
cord-015021-pol2qm74	1769	9	PMN	PMN	NNP
cord-015021-pol2qm74	1769	10	infiltration	infiltration	NN
cord-015021-pol2qm74	1769	11	into	into	IN
cord-015021-pol2qm74	1769	12	the	the	DT
cord-015021-pol2qm74	1769	13	interstitium	interstitium	NN
cord-015021-pol2qm74	1769	14	.	.	.
cord-015021-pol2qm74	1770	1	In	in	IN
cord-015021-pol2qm74	1770	2	conclusion	conclusion	NN
cord-015021-pol2qm74	1770	3	,	,	,
cord-015021-pol2qm74	1770	4	these	these	DT
cord-015021-pol2qm74	1770	5	data	datum	NNS
cord-015021-pol2qm74	1770	6	indicate	indicate	VBP
cord-015021-pol2qm74	1770	7	that	that	IN
cord-015021-pol2qm74	1770	8	PAF	PAF	NNP
cord-015021-pol2qm74	1770	9	is	be	VBZ
cord-015021-pol2qm74	1770	10	released	release	VBN
cord-015021-pol2qm74	1770	11	into	into	IN
cord-015021-pol2qm74	1770	12	the	the	DT
cord-015021-pol2qm74	1770	13	circulation	circulation	NN
cord-015021-pol2qm74	1770	14	during	during	IN
cord-015021-pol2qm74	1770	15	repeffusion	repeffusion	NN
cord-015021-pol2qm74	1770	16	,	,	,
cord-015021-pol2qm74	1770	17	and	and	CC
cord-015021-pol2qm74	1770	18	is	be	VBZ
cord-015021-pol2qm74	1770	19	likely	likely	RB
cord-015021-pol2qm74	1770	20	involved	involve	VBN
cord-015021-pol2qm74	1770	21	as	as	IN
cord-015021-pol2qm74	1770	22	a	a	DT
cord-015021-pol2qm74	1770	23	mediator	mediator	NN
cord-015021-pol2qm74	1770	24	in	in	IN
cord-015021-pol2qm74	1770	25	the	the	DT
cord-015021-pol2qm74	1770	26	observed	observe	VBN
cord-015021-pol2qm74	1770	27	PMN	PMN	NNP
cord-015021-pol2qm74	1770	28	oxidative	oxidative	JJ
cord-015021-pol2qm74	1770	29	burst	burst	NN
cord-015021-pol2qm74	1770	30	activity	activity	NN
cord-015021-pol2qm74	1770	31	,	,	,
cord-015021-pol2qm74	1770	32	thereby	thereby	RB
cord-015021-pol2qm74	1770	33	contributing	contribute	VBG
cord-015021-pol2qm74	1770	34	to	to	IN
cord-015021-pol2qm74	1770	35	reperfusien	reperfusien	NNP
cord-015021-pol2qm74	1770	36	injury	injury	NN
cord-015021-pol2qm74	1770	37	.	.	.
cord-015021-pol2qm74	1771	1	Following	follow	VBG
cord-015021-pol2qm74	1771	2	thermal	thermal	JJ
cord-015021-pol2qm74	1771	3	Injury	injury	NN
cord-015021-pol2qm74	1771	4	and	and	CC
cord-015021-pol2qm74	1771	5	Infection	Infection	NNP
cord-015021-pol2qm74	1771	6	granulocyte	granulocyte	NN
cord-015021-pol2qm74	1771	7	function	function	NN
cord-015021-pol2qm74	1771	8	ts	ts	XX
cord-015021-pol2qm74	1771	9	abnormal	abnormal	JJ
cord-015021-pol2qm74	1771	10	.	.	.
cord-015021-pol2qm74	1772	1	To	to	TO
cord-015021-pol2qm74	1772	2	elucidate	elucidate	VB
cord-015021-pol2qm74	1772	3	the	the	DT
cord-015021-pol2qm74	1772	4	mechanism	mechanism	NN
cord-015021-pol2qm74	1772	5	by	by	IN
cord-015021-pol2qm74	1772	6	which	which	WDT
cord-015021-pol2qm74	1772	7	thermal	thermal	JJ
cord-015021-pol2qm74	1772	8	injury	injury	NN
cord-015021-pol2qm74	1772	9	and	and	CC
cord-015021-pol2qm74	1772	10	Infection	Infection	NNP
cord-015021-pol2qm74	1772	11	affect	affect	VBP
cord-015021-pol2qm74	1772	12	the	the	DT
cord-015021-pol2qm74	1772	13	granulocyte	granulocyte	NN
cord-015021-pol2qm74	1772	14	's	's	POS
cord-015021-pol2qm74	1772	15	ability	ability	NN
cord-015021-pol2qm74	1772	16	to	to	TO
cord-015021-pol2qm74	1772	17	polymerize	polymerize	VB
cord-015021-pol2qm74	1772	18	and	and	CC
cord-015021-pol2qm74	1772	19	depolymedze	depolymedze	NNP
cord-015021-pol2qm74	1772	20	actin	actin	NNP
cord-015021-pol2qm74	1772	21	,	,	,
cord-015021-pol2qm74	1772	22	we	-PRON-	PRP
cord-015021-pol2qm74	1772	23	serially	serially	RB
cord-015021-pol2qm74	1772	24	measured	measure	VBD
cord-015021-pol2qm74	1772	25	F	F	NNP
cord-015021-pol2qm74	1772	26	-	-	HYPH
cord-015021-pol2qm74	1772	27	Actin	Actin	NNP
cord-015021-pol2qm74	1772	28	levels	level	NNS
cord-015021-pol2qm74	1772	29	in	in	IN
cord-015021-pol2qm74	1772	30	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1772	31	from	from	IN
cord-015021-pol2qm74	1772	32	14	14	CD
cord-015021-pol2qm74	1772	33	burned	burn	VBN
cord-015021-pol2qm74	1772	34	patients	patient	NNS
cord-015021-pol2qm74	1772	35	(	(	-LRB-
cord-015021-pol2qm74	1772	36	mean	mean	VB
cord-015021-pol2qm74	1772	37	age	age	NN
cord-015021-pol2qm74	1772	38	42,1	42,1	CD
cord-015021-pol2qm74	1773	1	+	+	CC
cord-015021-pol2qm74	1774	1	_	_	NN
cord-015021-pol2qm74	1774	2	17.7	17.7	CD
cord-015021-pol2qm74	1774	3	years	year	NNS
cord-015021-pol2qm74	1774	4	,	,	,
cord-015021-pol2qm74	1774	5	mean	mean	VB
cord-015021-pol2qm74	1774	6	burn	burn	NN
cord-015021-pol2qm74	1774	7	size	size	NN
cord-015021-pol2qm74	1774	8	39.8	39.8	CD
cord-015021-pol2qm74	1774	9	%	%	NN
cord-015021-pol2qm74	1775	1	_	_	NN
cord-015021-pol2qm74	1775	2	+	+	SYM
cord-015021-pol2qm74	1775	3	22.2	22.2	CD
cord-015021-pol2qm74	1775	4	%	%	NN
cord-015021-pol2qm74	1775	5	)	)	-RRB-
cord-015021-pol2qm74	1775	6	during	during	IN
cord-015021-pol2qm74	1775	7	the	the	DT
cord-015021-pol2qm74	1775	8	first	first	JJ
cord-015021-pol2qm74	1775	9	S	S	NNP
cord-015021-pol2qm74	1775	10	weeks	week	NNS
cord-015021-pol2qm74	1775	11	post	post	NN
cord-015021-pol2qm74	1775	12	injury	injury	NN
cord-015021-pol2qm74	1775	13	.	.	.
cord-015021-pol2qm74	1776	1	Six	six	CD
cord-015021-pol2qm74	1776	2	of	of	IN
cord-015021-pol2qm74	1776	3	the	the	DT
cord-015021-pol2qm74	1776	4	patients	patient	NNS
cord-015021-pol2qm74	1776	5	had	have	VBD
cord-015021-pol2qm74	1776	6	infections	infection	NNS
cord-015021-pol2qm74	1776	7	during	during	IN
cord-015021-pol2qm74	1776	8	the	the	DT
cord-015021-pol2qm74	1776	9	course	course	NN
cord-015021-pol2qm74	1776	10	of	of	IN
cord-015021-pol2qm74	1776	11	the	the	DT
cord-015021-pol2qm74	1776	12	study	study	NN
cord-015021-pol2qm74	1776	13	,	,	,
cord-015021-pol2qm74	1776	14	(	(	-LRB-
cord-015021-pol2qm74	1776	15	septicemia	septicemia	NN
cord-015021-pol2qm74	1776	16	,	,	,
cord-015021-pol2qm74	1776	17	wound	wound	JJ
cord-015021-pol2qm74	1776	18	Invasion	invasion	NN
cord-015021-pol2qm74	1776	19	and	and	CC
cord-015021-pol2qm74	1776	20	pneumonia	pneumonia	NN
cord-015021-pol2qm74	1776	21	)	)	-RRB-
cord-015021-pol2qm74	1776	22	.	.	.
cord-015021-pol2qm74	1777	1	Actin	actin	NN
cord-015021-pol2qm74	1777	2	levels	level	NNS
cord-015021-pol2qm74	1778	1	In	in	IN
cord-015021-pol2qm74	1778	2	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1778	3	from	from	IN
cord-015021-pol2qm74	1778	4	eleven	eleven	CD
cord-015021-pol2qm74	1778	5	healthy	healthy	JJ
cord-015021-pol2qm74	1778	6	volunteers	volunteer	NNS
cord-015021-pol2qm74	1778	7	(	(	-LRB-
cord-015021-pol2qm74	1778	8	mean	mean	VB
cord-015021-pol2qm74	1778	9	age	age	NN
cord-015021-pol2qm74	1778	10	34	34	CD
cord-015021-pol2qm74	1778	11	years	year	NNS
cord-015021-pol2qm74	1778	12	)	)	-RRB-
cord-015021-pol2qm74	1778	13	were	be	VBD
cord-015021-pol2qm74	1778	14	measured	measure	VBN
cord-015021-pol2qm74	1778	15	repeatedly	repeatedly	RB
cord-015021-pol2qm74	1778	16	and	and	CC
cord-015021-pol2qm74	1778	17	served	serve	VBD
cord-015021-pol2qm74	1778	18	as	as	IN
cord-015021-pol2qm74	1778	19	controls	control	NNS
cord-015021-pol2qm74	1778	20	.	.	.
cord-015021-pol2qm74	1779	1	Lysecl	Lysecl	NNP
cord-015021-pol2qm74	1779	2	white	white	JJ
cord-015021-pol2qm74	1779	3	blood	blood	NN
cord-015021-pol2qm74	1779	4	cell	cell	NN
cord-015021-pol2qm74	1779	5	preparations	preparation	NNS
cord-015021-pol2qm74	1779	6	were	be	VBD
cord-015021-pol2qm74	1779	7	brought	bring	VBN
cord-015021-pol2qm74	1779	8	to	to	IN
cord-015021-pol2qm74	1779	9	370C	370c	CD
cord-015021-pol2qm74	1779	10	and	and	CC
cord-015021-pol2qm74	1779	11	incubated	incubate	VBN
cord-015021-pol2qm74	1779	12	with	with	IN
cord-015021-pol2qm74	1779	13	N	N	NNP
cord-015021-pol2qm74	1779	14	-	-	HYPH
cord-015021-pol2qm74	1779	15	formyl	formyl	NNP
cord-015021-pol2qm74	1779	16	-	-	HYPH
cord-015021-pol2qm74	1779	17	met	met	NNP
cord-015021-pol2qm74	1779	18	-	-	HYPH
cord-015021-pol2qm74	1779	19	leu	leu	NN
cord-015021-pol2qm74	1779	20	-	-	HYPH
cord-015021-pol2qm74	1779	21	phe	phe	NNP
cord-015021-pol2qm74	1779	22	(	(	-LRB-
cord-015021-pol2qm74	1779	23	STIM	STIM	NNP
cord-015021-pol2qm74	1779	24	)	)	-RRB-
cord-015021-pol2qm74	1779	25	or	or	CC
cord-015021-pol2qm74	1779	26	with	with	IN
cord-015021-pol2qm74	1779	27	Dulbecco	Dulbecco	NNP
cord-015021-pol2qm74	1779	28	's	's	POS
cord-015021-pol2qm74	1779	29	phosphate	phosphate	NN
cord-015021-pol2qm74	1779	30	unbuffered	unbuffered	JJ
cord-015021-pol2qm74	1779	31	sellne	sellne	NNP
cord-015021-pol2qm74	1779	32	(	(	-LRB-
cord-015021-pol2qm74	1779	33	UNSTIM	UNSTIM	NNP
cord-015021-pol2qm74	1779	34	)	)	-RRB-
cord-015021-pol2qm74	1779	35	.	.	.
cord-015021-pol2qm74	1780	1	The	the	DT
cord-015021-pol2qm74	1780	2	cells	cell	NNS
cord-015021-pol2qm74	1780	3	were	be	VBD
cord-015021-pol2qm74	1780	4	concomitantly	concomitantly	RB
cord-015021-pol2qm74	1780	5	stained	stain	VBN
cord-015021-pol2qm74	1780	6	and	and	CC
cord-015021-pol2qm74	1780	7	fixed	fix	VBN
cord-015021-pol2qm74	1780	8	with	with	IN
cord-015021-pol2qm74	1780	9	formaldehyde	formaldehyde	NN
cord-015021-pol2qm74	1780	10	,	,	,
cord-015021-pol2qm74	1780	11	lysoleclthln	lysoleclthln	NNP
cord-015021-pol2qm74	1780	12	and	and	CC
cord-015021-pol2qm74	1780	13	fiuoresceln	fiuoresceln	NNP
cord-015021-pol2qm74	1780	14	phafioidin	phafioidin	NNP
cord-015021-pol2qm74	1780	15	.	.	.
cord-015021-pol2qm74	1781	1	Actin	actin	NN
cord-015021-pol2qm74	1781	2	depolymedzation	depolymedzation	NN
cord-015021-pol2qm74	1781	3	(	(	-LRB-
cord-015021-pol2qm74	1781	4	DEPOL	DEPOL	NNP
cord-015021-pol2qm74	1781	5	)	)	-RRB-
cord-015021-pol2qm74	1781	6	was	be	VBD
cord-015021-pol2qm74	1781	7	measured	measure	VBN
cord-015021-pol2qm74	1781	8	by	by	IN
cord-015021-pol2qm74	1781	9	Incubating	incubate	VBG
cord-015021-pol2qm74	1781	10	stimulated	stimulated	JJ
cord-015021-pol2qm74	1781	11	cells	cell	NNS
cord-015021-pol2qm74	1781	12	at	at	IN
cord-015021-pol2qm74	1781	13	0	0	CD
cord-015021-pol2qm74	1781	14	°	°	NN
cord-015021-pol2qm74	1781	15	C	c	NN
cord-015021-pol2qm74	1781	16	before	before	IN
cord-015021-pol2qm74	1781	17	the	the	DT
cord-015021-pol2qm74	1781	18	stain	stain	NN
cord-015021-pol2qm74	1781	19	-	-	HYPH
cord-015021-pol2qm74	1781	20	fixative	fixative	NN
cord-015021-pol2qm74	1781	21	was	be	VBD
cord-015021-pol2qm74	1781	22	added	add	VBN
cord-015021-pol2qm74	1781	23	.	.	.
cord-015021-pol2qm74	1782	1	Baseline	baseline	JJ
cord-015021-pol2qm74	1782	2	(	(	-LRB-
cord-015021-pol2qm74	1782	3	BASE	base	NN
cord-015021-pol2qm74	1782	4	)	)	-RRB-
cord-015021-pol2qm74	1783	1	F	F	NNP
cord-015021-pol2qm74	1783	2	-	-	HYPH
cord-015021-pol2qm74	1783	3	actln	actln	NN
cord-015021-pol2qm74	1783	4	levels	level	NNS
cord-015021-pol2qm74	1783	5	were	be	VBD
cord-015021-pol2qm74	1783	6	assessed	assess	VBN
cord-015021-pol2qm74	1783	7	by	by	IN
cord-015021-pol2qm74	1783	8	adding	add	VBG
cord-015021-pol2qm74	1783	9	stsln	stsln	NN
cord-015021-pol2qm74	1783	10	-	-	HYPH
cord-015021-pol2qm74	1783	11	fixatlve	fixatlve	NN
cord-015021-pol2qm74	1783	12	to	to	IN
cord-015021-pol2qm74	1783	13	Icecold	Icecold	NNP
cord-015021-pol2qm74	1783	14	unstimulated	unstimulated	JJ
cord-015021-pol2qm74	1783	15	cells	cell	NNS
cord-015021-pol2qm74	1783	16	.	.	.
cord-015021-pol2qm74	1784	1	Fluorescence	fluorescence	NN
cord-015021-pol2qm74	1784	2	was	be	VBD
cord-015021-pol2qm74	1784	3	estimated	estimate	VBN
cord-015021-pol2qm74	1784	4	In	in	IN
cord-015021-pol2qm74	1784	5	a	a	DT
cord-015021-pol2qm74	1784	6	FACSCAN	FACSCAN	NNP
cord-015021-pol2qm74	1784	7	and	and	CC
cord-015021-pol2qm74	1784	8	expressed	express	VBD
cord-015021-pol2qm74	1784	9	as	as	IN
cord-015021-pol2qm74	1784	10	Ilnesr	Ilnesr	NNP
cord-015021-pol2qm74	1784	11	mean	mean	VBP
cord-015021-pol2qm74	1784	12	channel	channel	NNP
cord-015021-pol2qm74	1784	13	fluorescence_+	fluorescence_+	VBZ
cord-015021-pol2qm74	1784	14	SEM	SEM	NNP
cord-015021-pol2qm74	1784	15	(	(	-LRB-
cord-015021-pol2qm74	1784	16	MCF	MCF	NNP
cord-015021-pol2qm74	1784	17	)	)	-RRB-
cord-015021-pol2qm74	1784	18	.	.	.
cord-015021-pol2qm74	1785	1	Figure	figure	NN
cord-015021-pol2qm74	1785	2	1	1	CD
cord-015021-pol2qm74	1785	3	displays	display	NNS
cord-015021-pol2qm74	1786	1	granulecyle	granulecyle	NNP
cord-015021-pol2qm74	1786	2	Fectln	Fectln	NNP
cord-015021-pol2qm74	1786	3	levels	level	NNS
cord-015021-pol2qm74	1786	4	In	in	IN
cord-015021-pol2qm74	1786	5	Infected	infected	JJ
cord-015021-pol2qm74	1786	6	and	and	CC
cord-015021-pol2qm74	1786	7	uninfected	uninfected	JJ
cord-015021-pol2qm74	1786	8	patients	patient	NNS
cord-015021-pol2qm74	1787	1	as	as	IN
cord-015021-pol2qm74	1787	2	compared	compare	VBN
cord-015021-pol2qm74	1787	3	to	to	IN
cord-015021-pol2qm74	1787	4	controls	control	NNS
cord-015021-pol2qm74	1787	5	.	.	.
cord-015021-pol2qm74	1788	1	F	F	NNP
cord-015021-pol2qm74	1788	2	-	-	HYPH
cord-015021-pol2qm74	1788	3	actln	actln	NN
cord-015021-pol2qm74	1788	4	levels	level	NNS
cord-015021-pol2qm74	1788	5	were	be	VBD
cord-015021-pol2qm74	1788	6	consistently	consistently	RB
cord-015021-pol2qm74	1788	7	lower	low	JJR
cord-015021-pol2qm74	1788	8	In	in	IN
cord-015021-pol2qm74	1788	9	control	control	NN
cord-015021-pol2qm74	1788	10	cells	cell	NNS
cord-015021-pol2qm74	1788	11	than	than	IN
cord-015021-pol2qm74	1788	12	In	in	IN
cord-015021-pol2qm74	1788	13	those	those	DT
cord-015021-pol2qm74	1788	14	from	from	IN
cord-015021-pol2qm74	1788	15	burned	burn	VBN
cord-015021-pol2qm74	1788	16	or	or	CC
cord-015021-pol2qm74	1788	17	burn	burn	VB
cord-015021-pol2qm74	1788	18	-	-	HYPH
cord-015021-pol2qm74	1788	19	infected	infect	VBN
cord-015021-pol2qm74	1788	20	patients	patient	NNS
cord-015021-pol2qm74	1788	21	under	under	IN
cord-015021-pol2qm74	1788	22	all	all	DT
cord-015021-pol2qm74	1788	23	measured	measure	VBN
cord-015021-pol2qm74	1788	24	conditions	condition	NNS
cord-015021-pol2qm74	1788	25	.	.	.
cord-015021-pol2qm74	1789	1	Granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1789	2	from	from	IN
cord-015021-pol2qm74	1789	3	Infected	Infected	NNP
cord-015021-pol2qm74	1789	4	burned	burn	VBN
cord-015021-pol2qm74	1789	5	patients	patient	NNS
cord-015021-pol2qm74	1789	6	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	1789	7	a	a	DT
cord-015021-pol2qm74	1789	8	significant	significant	JJ
cord-015021-pol2qm74	1789	9	decrement	decrement	NN
cord-015021-pol2qm74	1789	10	In	in	IN
cord-015021-pol2qm74	1789	11	their	-PRON-	PRP$
cord-015021-pol2qm74	1789	12	ability	ability	NN
cord-015021-pol2qm74	1789	13	to	to	TO
cord-015021-pol2qm74	1789	14	depofymerlze	depofymerlze	NNP
cord-015021-pol2qm74	1789	15	F.actin	F.actin	NNP
cord-015021-pol2qm74	1789	16	compared	compare	VBN
cord-015021-pol2qm74	1789	17	to	to	IN
cord-015021-pol2qm74	1789	18	both	both	DT
cord-015021-pol2qm74	1789	19	uninfected	uninfected	JJ
cord-015021-pol2qm74	1789	20	burned	burn	VBD
cord-015021-pol2qm74	1789	21	patients	patient	NNS
cord-015021-pol2qm74	1789	22	and	and	CC
cord-015021-pol2qm74	1789	23	controls	control	NNS
cord-015021-pol2qm74	1789	24	,	,	,
cord-015021-pol2qm74	1789	25	while	while	IN
cord-015021-pol2qm74	1789	26	there	there	EX
cord-015021-pol2qm74	1789	27	were	be	VBD
cord-015021-pol2qm74	1789	28	no	no	DT
cord-015021-pol2qm74	1789	29	significant	significant	JJ
cord-015021-pol2qm74	1789	30	differences	difference	NNS
cord-015021-pol2qm74	1789	31	between	between	IN
cord-015021-pol2qm74	1789	32	Infected	Infected	NNP
cord-015021-pol2qm74	1789	33	and	and	CC
cord-015021-pol2qm74	1789	34	1,~	1,~	CD
cord-015021-pol2qm74	1789	35	uninfected	uninfected	JJ
cord-015021-pol2qm74	1789	36	patients	patient	NNS
cord-015021-pol2qm74	1789	37	In	in	IN
cord-015021-pol2qm74	1789	38	the	the	DT
cord-015021-pol2qm74	1789	39	baseline	baseline	NN
cord-015021-pol2qm74	1789	40	,	,	,
cord-015021-pol2qm74	1789	41	unstlmuleted	unstlmuleted	JJ
cord-015021-pol2qm74	1789	42	and	and	CC
cord-015021-pol2qm74	1789	43	stimulated	stimulate	VBN
cord-015021-pol2qm74	1789	44	conditions	condition	NNS
cord-015021-pol2qm74	1789	45	.	.	.
cord-015021-pol2qm74	1790	1	Those	those	DT
cord-015021-pol2qm74	1790	2	results	result	NNS
cord-015021-pol2qm74	1790	3	Indicate	indicate	VBP
cord-015021-pol2qm74	1790	4	la5	la5	NNS
cord-015021-pol2qm74	1790	5	that	that	DT
cord-015021-pol2qm74	1790	6	grsnulocytas	grsnulocytas	NN
cord-015021-pol2qm74	1790	7	from	from	IN
cord-015021-pol2qm74	1790	8	burned	burned	JJ
cord-015021-pol2qm74	1790	9	and	and	CC
cord-015021-pol2qm74	1790	10	bum	bum	NN
cord-015021-pol2qm74	1790	11	-	-	HYPH
cord-015021-pol2qm74	1790	12	Infected	infect	VBN
cord-015021-pol2qm74	1790	13	patients	patient	NNS
cord-015021-pol2qm74	1790	14	contain	contain	VBP
cord-015021-pol2qm74	1790	15	higher	high	JJR
cord-015021-pol2qm74	1790	16	levels	level	NNS
cord-015021-pol2qm74	1790	17	of	of	IN
cord-015021-pol2qm74	1790	18	polymerized	polymerize	VBN
cord-015021-pol2qm74	1790	19	actln	actln	NN
cord-015021-pol2qm74	1790	20	than	than	IN
cord-015021-pol2qm74	1790	21	~	~	CD
cord-015021-pol2qm74	1790	22	,	,	,
cord-015021-pol2qm74	1790	23	2S	2s	CD
cord-015021-pol2qm74	1790	24	control	control	NN
cord-015021-pol2qm74	1790	25	cells	cell	NNS
cord-015021-pol2qm74	1790	26	.	.	.
cord-015021-pol2qm74	1791	1	In	in	IN
cord-015021-pol2qm74	1791	2	order	order	NN
cord-015021-pol2qm74	1791	3	to	to	TO
cord-015021-pol2qm74	1791	4	study	study	VB
cord-015021-pol2qm74	1791	5	tumor	tumor	NN
cord-015021-pol2qm74	1791	6	necrosis	necrosis	NN
cord-015021-pol2qm74	1791	7	factor	factor	NN
cord-015021-pol2qm74	1791	8	(	(	-LRB-
cord-015021-pol2qm74	1791	9	TNF	TNF	NNP
cord-015021-pol2qm74	1791	10	)	)	-RRB-
cord-015021-pol2qm74	1791	11	receptor	receptor	NN
cord-015021-pol2qm74	1791	12	sensitivity	sensitivity	NN
cord-015021-pol2qm74	1791	13	in	in	IN
cord-015021-pol2qm74	1791	14	septic	septic	NN
cord-015021-pol2qm74	1791	15	critically	critically	RB
cord-015021-pol2qm74	1791	16	ill	ill	JJ
cord-015021-pol2qm74	1791	17	patients	patient	NNS
cord-015021-pol2qm74	1791	18	we	-PRON-	PRP
cord-015021-pol2qm74	1791	19	investigated	investigate	VBD
cord-015021-pol2qm74	1791	20	20	20	CD
cord-015021-pol2qm74	1791	21	blood	blood	NN
cord-015021-pol2qm74	1791	22	samples	sample	NNS
cord-015021-pol2qm74	1791	23	of	of	IN
cord-015021-pol2qm74	1791	24	such	such	JJ
cord-015021-pol2qm74	1791	25	people	people	NNS
cord-015021-pol2qm74	1791	26	in	in	IN
cord-015021-pol2qm74	1791	27	reaction	reaction	NN
cord-015021-pol2qm74	1791	28	of	of	IN
cord-015021-pol2qm74	1791	29	leucocyte	leucocyte	NNP
cord-015021-pol2qm74	1791	30	migration	migration	NN
cord-015021-pol2qm74	1791	31	inhibition	inhibition	NN
cord-015021-pol2qm74	1791	32	.	.	.
cord-015021-pol2qm74	1792	1	Migration	migration	NN
cord-015021-pol2qm74	1792	2	of	of	IN
cord-015021-pol2qm74	1792	3	their	-PRON-	PRP$
cord-015021-pol2qm74	1792	4	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	1792	5	leucocytes	leucocytes	NNP
cord-015021-pol2qm74	1792	6	(	(	-LRB-
cord-015021-pol2qm74	1792	7	PMNs	PMNs	NNP
cord-015021-pol2qm74	1792	8	)	)	-RRB-
cord-015021-pol2qm74	1792	9	was	be	VBD
cord-015021-pol2qm74	1792	10	studied	study	VBN
cord-015021-pol2qm74	1792	11	with	with	IN
cord-015021-pol2qm74	1792	12	stimulation	stimulation	NN
cord-015021-pol2qm74	1792	13	with	with	IN
cord-015021-pol2qm74	1792	14	human	human	JJ
cord-015021-pol2qm74	1792	15	recombinant	recombinant	JJ
cord-015021-pol2qm74	1792	16	TNF	TNF	NNP
cord-015021-pol2qm74	1792	17	in	in	IN
cord-015021-pol2qm74	1792	18	concentration	concentration	NN
cord-015021-pol2qm74	1792	19	of	of	IN
cord-015021-pol2qm74	1792	20	166.7	166.7	CD
cord-015021-pol2qm74	1792	21	U	U	NNP
cord-015021-pol2qm74	1792	22	/	/	SYM
cord-015021-pol2qm74	1792	23	ml	ml	NN
cord-015021-pol2qm74	1792	24	(	(	-LRB-
cord-015021-pol2qm74	1792	25	recommended	recommend	VBN
cord-015021-pol2qm74	1792	26	by	by	IN
cord-015021-pol2qm74	1792	27	manufacturer	manufacturer	NN
cord-015021-pol2qm74	1792	28	is	be	VBZ
cord-015021-pol2qm74	1792	29	the	the	DT
cord-015021-pol2qm74	1792	30	range	range	NN
cord-015021-pol2qm74	1792	31	of	of	IN
cord-015021-pol2qm74	1792	32	10	10	CD
cord-015021-pol2qm74	1792	33	-	-	SYM
cord-015021-pol2qm74	1792	34	200	200	CD
cord-015021-pol2qm74	1792	35	O	o	NN
cord-015021-pol2qm74	1792	36	/	/	SYM
cord-015021-pol2qm74	1792	37	ml	ml	NN
cord-015021-pol2qm74	1792	38	)	)	-RRB-
cord-015021-pol2qm74	1792	39	and	and	CC
cord-015021-pol2qm74	1792	40	without	without	IN
cord-015021-pol2qm74	1792	41	such	such	JJ
cord-015021-pol2qm74	1792	42	.	.	.
cord-015021-pol2qm74	1793	1	Ten	ten	CD
cord-015021-pol2qm74	1793	2	healthy	healthy	JJ
cord-015021-pol2qm74	1793	3	blood	blood	NN
cord-015021-pol2qm74	1793	4	donors	donor	NNS
cord-015021-pol2qm74	1793	5	formed	form	VBD
cord-015021-pol2qm74	1793	6	control	control	NN
cord-015021-pol2qm74	1793	7	group	group	NN
cord-015021-pol2qm74	1793	8	.	.	.
cord-015021-pol2qm74	1794	1	The	the	DT
cord-015021-pol2qm74	1794	2	results	result	NNS
cord-015021-pol2qm74	1794	3	obtained	obtain	VBN
cord-015021-pol2qm74	1794	4	showed	show	VBD
cord-015021-pol2qm74	1794	5	diminished	diminish	VBN
cord-015021-pol2qm74	1794	6	PMN	PMN	NNP
cord-015021-pol2qm74	1794	7	reactivity	reactivity	NN
cord-015021-pol2qm74	1794	8	to	to	IN
cord-015021-pol2qm74	1794	9	TNF	TNF	NNP
cord-015021-pol2qm74	1794	10	in	in	IN
cord-015021-pol2qm74	1794	11	patients	patient	NNS
cord-015021-pol2qm74	1794	12	(	(	-LRB-
cord-015021-pol2qm74	1794	13	migration	migration	NN
cord-015021-pol2qm74	1794	14	inhibition	inhibition	NN
cord-015021-pol2qm74	1794	15	was	be	VBD
cord-015021-pol2qm74	1794	16	absent	absent	JJ
cord-015021-pol2qm74	1794	17	)	)	-RRB-
cord-015021-pol2qm74	1794	18	oscaring	oscare	VBG
cord-015021-pol2qm74	1794	19	with	with	IN
cord-015021-pol2qm74	1794	20	significantly	significantly	RB
cord-015021-pol2qm74	1794	21	increased	increase	VBN
cord-015021-pol2qm74	1794	22	migration	migration	NN
cord-015021-pol2qm74	1794	23	ability	ability	NN
cord-015021-pol2qm74	1794	24	of	of	IN
cord-015021-pol2qm74	1794	25	their	-PRON-	PRP$
cord-015021-pol2qm74	1794	26	PMNs	pmn	NNS
cord-015021-pol2qm74	1794	27	(	(	-LRB-
cord-015021-pol2qm74	1794	28	107.2	107.2	CD
cord-015021-pol2qm74	1794	29	%	%	NN
cord-015021-pol2qm74	1794	30	of	of	IN
cord-015021-pol2qm74	1794	31	that	that	DT
cord-015021-pol2qm74	1794	32	in	in	IN
cord-015021-pol2qm74	1794	33	control	control	NN
cord-015021-pol2qm74	1794	34	group	group	NN
cord-015021-pol2qm74	1794	35	)	)	-RRB-
cord-015021-pol2qm74	1794	36	.	.	.
cord-015021-pol2qm74	1795	1	At	at	IN
cord-015021-pol2qm74	1795	2	the	the	DT
cord-015021-pol2qm74	1795	3	same	same	JJ
cord-015021-pol2qm74	1795	4	time	time	NN
cord-015021-pol2qm74	1795	5	normal	normal	JJ
cord-015021-pol2qm74	1795	6	PMNs	pmn	NNS
cord-015021-pol2qm74	1795	7	in	in	IN
cord-015021-pol2qm74	1795	8	control	control	NN
cord-015021-pol2qm74	1795	9	group	group	NN
cord-015021-pol2qm74	1795	10	did	do	VBD
cord-015021-pol2qm74	1795	11	show	show	VB
cord-015021-pol2qm74	1795	12	migration	migration	NN
cord-015021-pol2qm74	1795	13	changes	change	NNS
cord-015021-pol2qm74	1795	14	upon	upon	IN
cord-015021-pol2qm74	1795	15	TNF	TNF	NNP
cord-015021-pol2qm74	1795	16	stimulation	stimulation	NN
cord-015021-pol2qm74	1795	17	.	.	.
cord-015021-pol2qm74	1796	1	Considering	consider	VBG
cord-015021-pol2qm74	1796	2	all	all	PDT
cord-015021-pol2qm74	1796	3	the	the	DT
cord-015021-pol2qm74	1796	4	above	above	IN
cord-015021-pol2qm74	1796	5	we	-PRON-	PRP
cord-015021-pol2qm74	1796	6	come	come	VBP
cord-015021-pol2qm74	1796	7	to	to	IN
cord-015021-pol2qm74	1796	8	a	a	DT
cord-015021-pol2qm74	1796	9	conclusion	conclusion	NN
cord-015021-pol2qm74	1796	10	that	that	IN
cord-015021-pol2qm74	1796	11	externally	externally	RB
cord-015021-pol2qm74	1796	12	added	add	VBD
cord-015021-pol2qm74	1796	13	TNF	TNF	NNP
cord-015021-pol2qm74	1796	14	fails	fail	VBZ
cord-015021-pol2qm74	1796	15	to	to	TO
cord-015021-pol2qm74	1796	16	activate	activate	VB
cord-015021-pol2qm74	1796	17	PMNs	pmn	NNS
cord-015021-pol2qm74	1796	18	in	in	IN
cord-015021-pol2qm74	1796	19	critically	critically	RB
cord-015021-pol2qm74	1796	20	ill	ill	JJ
cord-015021-pol2qm74	1796	21	patients	patient	NNS
cord-015021-pol2qm74	1796	22	more	more	RBR
cord-015021-pol2qm74	1796	23	than	than	IN
cord-015021-pol2qm74	1796	24	they	-PRON-	PRP
cord-015021-pol2qm74	1796	25	are	be	VBP
cord-015021-pol2qm74	1796	26	by	by	IN
cord-015021-pol2qm74	1796	27	their	-PRON-	PRP$
cord-015021-pol2qm74	1796	28	endogenous	endogenous	JJ
cord-015021-pol2qm74	1796	29	TNF	TNF	NNP
cord-015021-pol2qm74	1796	30	.	.	.
cord-015021-pol2qm74	1797	1	Moreover	moreover	RB
cord-015021-pol2qm74	1797	2	,	,	,
cord-015021-pol2qm74	1797	3	this	this	DT
cord-015021-pol2qm74	1797	4	TNF	tnf	NN
cord-015021-pol2qm74	1797	5	no	no	RB
cord-015021-pol2qm74	1797	6	longer	long	RBR
cord-015021-pol2qm74	1797	7	serves	serve	VBZ
cord-015021-pol2qm74	1797	8	a	a	DT
cord-015021-pol2qm74	1797	9	positive	positive	JJ
cord-015021-pol2qm74	1797	10	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	1797	11	factor	factor	NN
cord-015021-pol2qm74	1797	12	for	for	IN
cord-015021-pol2qm74	1797	13	such	such	JJ
cord-015021-pol2qm74	1797	14	PMNs	pmn	NNS
cord-015021-pol2qm74	1797	15	.	.	.
cord-015021-pol2qm74	1798	1	These	these	DT
cord-015021-pol2qm74	1798	2	findings	finding	NNS
cord-015021-pol2qm74	1798	3	may	may	MD
cord-015021-pol2qm74	1798	4	suggest	suggest	VB
cord-015021-pol2qm74	1798	5	that	that	IN
cord-015021-pol2qm74	1798	6	in	in	IN
cord-015021-pol2qm74	1798	7	critically	critically	RB
cord-015021-pol2qm74	1798	8	ill	ill	JJ
cord-015021-pol2qm74	1798	9	septic	septic	JJ
cord-015021-pol2qm74	1798	10	patients	patient	NNS
cord-015021-pol2qm74	1798	11	reactivity	reactivity	NN
cord-015021-pol2qm74	1798	12	of	of	IN
cord-015021-pol2qm74	1798	13	PMNs	pmn	NNS
cord-015021-pol2qm74	1798	14	to	to	IN
cord-015021-pol2qm74	1798	15	TNF	TNF	NNP
cord-015021-pol2qm74	1798	16	is	be	VBZ
cord-015021-pol2qm74	1798	17	deeply	deeply	RB
cord-015021-pol2qm74	1798	18	altered	alter	VBN
cord-015021-pol2qm74	1798	19	.	.	.
cord-015021-pol2qm74	1799	1	TNF	TNF	NNP
cord-015021-pol2qm74	1799	2	receptors	receptor	NNS
cord-015021-pol2qm74	1799	3	of	of	IN
cord-015021-pol2qm74	1799	4	PMNs	pmn	NNS
cord-015021-pol2qm74	1799	5	are	be	VBP
cord-015021-pol2qm74	1799	6	either	either	RB
cord-015021-pol2qm74	1799	7	exhausted	exhaust	VBN
cord-015021-pol2qm74	1799	8	as	as	IN
cord-015021-pol2qm74	1799	9	such	such	JJ
cord-015021-pol2qm74	1799	10	by	by	IN
cord-015021-pol2qm74	1799	11	excessive	excessive	JJ
cord-015021-pol2qm74	1799	12	stimulation	stimulation	NN
cord-015021-pol2qm74	1799	13	with	with	IN
cord-015021-pol2qm74	1799	14	endogenous	endogenous	JJ
cord-015021-pol2qm74	1799	15	TNF	TNF	NNP
cord-015021-pol2qm74	1799	16	or	or	CC
cord-015021-pol2qm74	1799	17	further	further	JJ
cord-015021-pol2qm74	1799	18	transmission	transmission	NN
cord-015021-pol2qm74	1799	19	of	of	IN
cord-015021-pol2qm74	1799	20	their	-PRON-	PRP$
cord-015021-pol2qm74	1799	21	message	message	NN
cord-015021-pol2qm74	1799	22	is	be	VBZ
cord-015021-pol2qm74	1799	23	impossible	impossible	JJ
cord-015021-pol2qm74	1799	24	due	due	IN
cord-015021-pol2qm74	1799	25	to	to	IN
cord-015021-pol2qm74	1799	26	"	"	``
cord-015021-pol2qm74	1799	27	fatigue	fatigue	NN
cord-015021-pol2qm74	1799	28	"	"	''
cord-015021-pol2qm74	1799	29	of	of	IN
cord-015021-pol2qm74	1799	30	the	the	DT
cord-015021-pol2qm74	1799	31	cell	cell	NN
cord-015021-pol2qm74	1799	32	's	's	POS
cord-015021-pol2qm74	1799	33	activation	activation	NN
cord-015021-pol2qm74	1799	34	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1799	35	.	.	.
cord-015021-pol2qm74	1800	1	We	-PRON-	PRP
cord-015021-pol2qm74	1800	2	express	express	VBP
cord-015021-pol2qm74	1800	3	our	-PRON-	PRP$
cord-015021-pol2qm74	1800	4	gratitude	gratitude	NN
cord-015021-pol2qm74	1800	5	to	to	IN
cord-015021-pol2qm74	1800	6	REANAL	REANAL	NNP
cord-015021-pol2qm74	1800	7	Factory	Factory	NNP
cord-015021-pol2qm74	1800	8	of	of	IN
cord-015021-pol2qm74	1800	9	Laboratory	Laboratory	NNP
cord-015021-pol2qm74	1800	10	Chemicals	Chemicals	NNPS
cord-015021-pol2qm74	1800	11	for	for	IN
cord-015021-pol2qm74	1800	12	generously	generously	RB
cord-015021-pol2qm74	1800	13	providing	provide	VBG
cord-015021-pol2qm74	1800	14	us	-PRON-	PRP
cord-015021-pol2qm74	1800	15	with	with	IN
cord-015021-pol2qm74	1800	16	a	a	DT
cord-015021-pol2qm74	1800	17	TNF	tnf	NN
cord-015021-pol2qm74	1800	18	com	com	NN
cord-015021-pol2qm74	1800	19	~	~	NFP
cord-015021-pol2qm74	1800	20	rcial	rcial	JJ
cord-015021-pol2qm74	1800	21	sample	sample	NN
cord-015021-pol2qm74	1800	22	.	.	.
cord-015021-pol2qm74	1801	1	~-SANGUIS	~-SANGUIS	NFP
cord-015021-pol2qm74	1801	2	Medical	medical	JJ
cord-015021-pol2qm74	1801	3	,	,	,
cord-015021-pol2qm74	1801	4	Ekaterineburg	Ekaterineburg	NNP
cord-015021-pol2qm74	1801	5	Russia	Russia	NNP
cord-015021-pol2qm74	1801	6	;	;	:
cord-015021-pol2qm74	1801	7	S	S	NNP
cord-015021-pol2qm74	1801	8	-	-	HYPH
cord-015021-pol2qm74	1801	9	Urals	Urals	NNP
cord-015021-pol2qm74	1801	10	Med.lnst	Med.lnst	NNP
cord-015021-pol2qm74	1801	11	.	.	.
cord-015021-pol2qm74	1802	1	Activated	activate	VBN
cord-015021-pol2qm74	1802	2	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1802	3	infiltrating	infiltrate	VBG
cord-015021-pol2qm74	1802	4	the	the	DT
cord-015021-pol2qm74	1802	5	local	local	JJ
cord-015021-pol2qm74	1802	6	site	site	NN
cord-015021-pol2qm74	1802	7	of	of	IN
cord-015021-pol2qm74	1802	8	inflammation	inflammation	NN
cord-015021-pol2qm74	1802	9	following	follow	VBG
cord-015021-pol2qm74	1802	10	trauma	trauma	NN
cord-015021-pol2qm74	1802	11	release	release	VBP
cord-015021-pol2qm74	1802	12	high	high	JJ
cord-015021-pol2qm74	1802	13	amounts	amount	NNS
cord-015021-pol2qm74	1802	14	of	of	IN
cord-015021-pol2qm74	1802	15	destructive	destructive	JJ
cord-015021-pol2qm74	1802	16	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	1802	17	enzymes	enzyme	NNS
cord-015021-pol2qm74	1802	18	into	into	IN
cord-015021-pol2qm74	1802	19	the	the	DT
cord-015021-pol2qm74	1802	20	extracellular	extracellular	JJ
cord-015021-pol2qm74	1802	21	space	space	NN
cord-015021-pol2qm74	1802	22	.	.	.
cord-015021-pol2qm74	1803	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	1803	2	were	be	VBD
cord-015021-pol2qm74	1803	3	discussed	discuss	VBN
cord-015021-pol2qm74	1803	4	to	to	TO
cord-015021-pol2qm74	1803	5	be	be	VB
cord-015021-pol2qm74	1803	6	involved	involve	VBN
cord-015021-pol2qm74	1803	7	in	in	IN
cord-015021-pol2qm74	1803	8	regulation	regulation	NN
cord-015021-pol2qm74	1803	9	of	of	IN
cord-015021-pol2qm74	1803	10	this	this	DT
cord-015021-pol2qm74	1803	11	early	early	JJ
cord-015021-pol2qm74	1803	12	process	process	NN
cord-015021-pol2qm74	1803	13	.	.	.
cord-015021-pol2qm74	1804	1	The	the	DT
cord-015021-pol2qm74	1804	2	task	task	NN
cord-015021-pol2qm74	1804	3	of	of	IN
cord-015021-pol2qm74	1804	4	this	this	DT
cord-015021-pol2qm74	1804	5	investigation	investigation	NN
cord-015021-pol2qm74	1804	6	was	be	VBD
cord-015021-pol2qm74	1804	7	to	to	TO
cord-015021-pol2qm74	1804	8	evaluate	evaluate	VB
cord-015021-pol2qm74	1804	9	the	the	DT
cord-015021-pol2qm74	1804	10	possible	possible	JJ
cord-015021-pol2qm74	1804	11	regulatory	regulatory	JJ
cord-015021-pol2qm74	1804	12	role	role	NN
cord-015021-pol2qm74	1804	13	of	of	IN
cord-015021-pol2qm74	1804	14	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	1804	15	(	(	-LRB-
cord-015021-pol2qm74	1804	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	1804	17	)	)	-RRB-
cord-015021-pol2qm74	1804	18	and	and	CC
cord-015021-pol2qm74	1804	19	its	-PRON-	PRP$
cord-015021-pol2qm74	1804	20	potential	potential	JJ
cord-015021-pol2qm74	1804	21	immunosupressive	immunosupressive	JJ
cord-015021-pol2qm74	1804	22	opponent	opponent	NN
cord-015021-pol2qm74	1804	23	,	,	,
cord-015021-pol2qm74	1804	24	the	the	DT
cord-015021-pol2qm74	1804	25	transforming	transform	VBG
cord-015021-pol2qm74	1804	26	growth	growth	NN
cord-015021-pol2qm74	1804	27	factor-	factor-	NNP
cord-015021-pol2qm74	1804	28	&	&	CC
cord-015021-pol2qm74	1804	29	,	,	,
cord-015021-pol2qm74	1804	30	in	in	IN
cord-015021-pol2qm74	1804	31	regulation	regulation	NN
cord-015021-pol2qm74	1804	32	of	of	IN
cord-015021-pol2qm74	1804	33	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1804	34	degranulation	degranulation	NN
cord-015021-pol2qm74	1804	35	.	.	.
cord-015021-pol2qm74	1805	1	We	-PRON-	PRP
cord-015021-pol2qm74	1805	2	analysed	analyse	VBD
cord-015021-pol2qm74	1805	3	the	the	DT
cord-015021-pol2qm74	1805	4	concentration	concentration	NN
cord-015021-pol2qm74	1805	5	of	of	IN
cord-015021-pol2qm74	1805	6	the	the	DT
cord-015021-pol2qm74	1805	7	al	al	NNP
cord-015021-pol2qm74	1805	8	-	-	HYPH
cord-015021-pol2qm74	1805	9	proteinase	proteinase	NN
cord-015021-pol2qm74	1805	10	-	-	HYPH
cord-015021-pol2qm74	1805	11	inhibitor	inhibitor	NN
cord-015021-pol2qm74	1805	12	complex	complex	NN
cord-015021-pol2qm74	1805	13	of	of	IN
cord-015021-pol2qm74	1805	14	the	the	DT
cord-015021-pol2qm74	1805	15	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	1805	16	elastase	elastase	NN
cord-015021-pol2qm74	1805	17	as	as	IN
cord-015021-pol2qm74	1805	18	marker	marker	NN
cord-015021-pol2qm74	1805	19	for	for	IN
cord-015021-pol2qm74	1805	20	the	the	DT
cord-015021-pol2qm74	1805	21	degranulation	degranulation	NN
cord-015021-pol2qm74	1805	22	of	of	IN
cord-015021-pol2qm74	1805	23	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1805	24	as	as	RB
cord-015021-pol2qm74	1805	25	well	well	RB
cord-015021-pol2qm74	1805	26	as	as	IN
cord-015021-pol2qm74	1805	27	the	the	DT
cord-015021-pol2qm74	1805	28	levels	level	NNS
cord-015021-pol2qm74	1805	29	of	of	IN
cord-015021-pol2qm74	1805	30	IL-6	IL-6	NNP
cord-015021-pol2qm74	1805	31	and	and	CC
cord-015021-pol2qm74	1805	32	TGF-61	TGF-61	NNP
cord-015021-pol2qm74	1805	33	in	in	IN
cord-015021-pol2qm74	1805	34	the	the	DT
cord-015021-pol2qm74	1805	35	plasma	plasma	NN
cord-015021-pol2qm74	1805	36	probes	probe	NNS
cord-015021-pol2qm74	1805	37	of	of	IN
cord-015021-pol2qm74	1805	38	patients	patient	NNS
cord-015021-pol2qm74	1805	39	undergoing	undergo	VBG
cord-015021-pol2qm74	1805	40	multiple	multiple	JJ
cord-015021-pol2qm74	1805	41	trauma	trauma	NN
cord-015021-pol2qm74	1805	42	and	and	CC
cord-015021-pol2qm74	1805	43	severe	severe	JJ
cord-015021-pol2qm74	1805	44	surgeries	surgery	NNS
cord-015021-pol2qm74	1805	45	.	.	.
cord-015021-pol2qm74	1806	1	The	the	DT
cord-015021-pol2qm74	1806	2	time	time	NN
cord-015021-pol2qm74	1806	3	courses	course	NNS
cord-015021-pol2qm74	1806	4	of	of	IN
cord-015021-pol2qm74	1806	5	IL-6	IL-6	NNP
cord-015021-pol2qm74	1806	6	and	and	CC
cord-015021-pol2qm74	1806	7	elastase	elastase	NN
cord-015021-pol2qm74	1806	8	were	be	VBD
cord-015021-pol2qm74	1806	9	found	find	VBN
cord-015021-pol2qm74	1806	10	to	to	TO
cord-015021-pol2qm74	1806	11	be	be	VB
cord-015021-pol2qm74	1806	12	highly	highly	RB
cord-015021-pol2qm74	1806	13	correlated	correlate	VBN
cord-015021-pol2qm74	1806	14	,	,	,
cord-015021-pol2qm74	1806	15	wheras	whera	VBZ
cord-015021-pol2qm74	1806	16	the	the	DT
cord-015021-pol2qm74	1806	17	concentrations	concentration	NNS
cord-015021-pol2qm74	1806	18	of	of	IN
cord-015021-pol2qm74	1806	19	the	the	DT
cord-015021-pol2qm74	1806	20	cytokine	cytokine	NN
cord-015021-pol2qm74	1806	21	TGF	TGF	NNP
cord-015021-pol2qm74	1806	22	-	-	HYPH
cord-015021-pol2qm74	1806	23	E~	E~	NNS
cord-015021-pol2qm74	1806	24	were	be	VBD
cord-015021-pol2qm74	1806	25	found	find	VBN
cord-015021-pol2qm74	1806	26	to	to	TO
cord-015021-pol2qm74	1806	27	be	be	VB
cord-015021-pol2qm74	1806	28	not	not	RB
cord-015021-pol2qm74	1806	29	significantly	significantly	RB
cord-015021-pol2qm74	1806	30	altered	alter	VBN
cord-015021-pol2qm74	1806	31	in	in	IN
cord-015021-pol2qm74	1806	32	comparison	comparison	NN
cord-015021-pol2qm74	1806	33	to	to	IN
cord-015021-pol2qm74	1806	34	the	the	DT
cord-015021-pol2qm74	1806	35	control	control	NN
cord-015021-pol2qm74	1806	36	group	group	NN
cord-015021-pol2qm74	1806	37	.	.	.
cord-015021-pol2qm74	1807	1	This	this	DT
cord-015021-pol2qm74	1807	2	close	close	JJ
cord-015021-pol2qm74	1807	3	temporal	temporal	JJ
cord-015021-pol2qm74	1807	4	correlationship	correlationship	NN
cord-015021-pol2qm74	1807	5	was	be	VBD
cord-015021-pol2qm74	1807	6	confirmed	confirm	VBN
cord-015021-pol2qm74	1807	7	by	by	IN
cord-015021-pol2qm74	1807	8	investigation	investigation	NN
cord-015021-pol2qm74	1807	9	of	of	IN
cord-015021-pol2qm74	1807	10	fluids	fluid	NNS
cord-015021-pol2qm74	1807	11	derived	derive	VBN
cord-015021-pol2qm74	1807	12	from	from	IN
cord-015021-pol2qm74	1807	13	sites	site	NNS
cord-015021-pol2qm74	1807	14	of	of	IN
cord-015021-pol2qm74	1807	15	inflammation	inflammation	NN
cord-015021-pol2qm74	1807	16	.	.	.
cord-015021-pol2qm74	1808	1	Interstingly	interstingly	RB
cord-015021-pol2qm74	1808	2	,	,	,
cord-015021-pol2qm74	1808	3	the	the	DT
cord-015021-pol2qm74	1808	4	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1808	5	potential	potential	NN
cord-015021-pol2qm74	1808	6	(	(	-LRB-
cord-015021-pol2qm74	1808	7	~zcproteinase	~zcproteinase	CD
cord-015021-pol2qm74	1808	8	inhibitor	inhibitor	NN
cord-015021-pol2qm74	1808	9	,	,	,
cord-015021-pol2qm74	1808	10	antithrombin	antithrombin	NN
cord-015021-pol2qm74	1808	11	III	III	NNP
cord-015021-pol2qm74	1808	12	)	)	-RRB-
cord-015021-pol2qm74	1808	13	was	be	VBD
cord-015021-pol2qm74	1808	14	dramatically	dramatically	RB
cord-015021-pol2qm74	1808	15	reduced	reduce	VBN
cord-015021-pol2qm74	1808	16	in	in	IN
cord-015021-pol2qm74	1808	17	the	the	DT
cord-015021-pol2qm74	1808	18	early	early	JJ
cord-015021-pol2qm74	1808	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1808	20	phase	phase	NN
cord-015021-pol2qm74	1808	21	.	.	.
cord-015021-pol2qm74	1809	1	To	to	TO
cord-015021-pol2qm74	1809	2	prove	prove	VB
cord-015021-pol2qm74	1809	3	this	this	DT
cord-015021-pol2qm74	1809	4	in	in	IN
cord-015021-pol2qm74	1809	5	vivo	vivo	NN
cord-015021-pol2qm74	1809	6	findings	finding	NNS
cord-015021-pol2qm74	1809	7	,	,	,
cord-015021-pol2qm74	1809	8	the	the	DT
cord-015021-pol2qm74	1809	9	effects	effect	NNS
cord-015021-pol2qm74	1809	10	of	of	IN
cord-015021-pol2qm74	1809	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	1809	12	and	and	CC
cord-015021-pol2qm74	1809	13	TGF	TGF	NNP
cord-015021-pol2qm74	1809	14	-	-	HYPH
cord-015021-pol2qm74	1809	15	I~	I~	NNP
cord-015021-pol2qm74	1809	16	1	1	CD
cord-015021-pol2qm74	1809	17	on	on	IN
cord-015021-pol2qm74	1809	18	the	the	DT
cord-015021-pol2qm74	1809	19	degranulation	degranulation	NN
cord-015021-pol2qm74	1809	20	of	of	IN
cord-015021-pol2qm74	1809	21	isolated	isolate	VBN
cord-015021-pol2qm74	1809	22	human	human	JJ
cord-015021-pol2qm74	1809	23	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1809	24	of	of	IN
cord-015021-pol2qm74	1809	25	healthy	healthy	JJ
cord-015021-pol2qm74	1809	26	donors	donor	NNS
cord-015021-pol2qm74	1809	27	was	be	VBD
cord-015021-pol2qm74	1809	28	investigated	investigate	VBN
cord-015021-pol2qm74	1809	29	in	in	IN
cord-015021-pol2qm74	1809	30	vitro	vitro	FW
cord-015021-pol2qm74	1809	31	.	.	.
cord-015021-pol2qm74	1810	1	Pathological	pathological	JJ
cord-015021-pol2qm74	1810	2	high	high	JJ
cord-015021-pol2qm74	1810	3	concentrations	concentration	NNS
cord-015021-pol2qm74	1810	4	of	of	IN
cord-015021-pol2qm74	1810	5	rhlL-6	rhlL-6	VBG
cord-015021-pol2qm74	1810	6	up	up	IN
cord-015021-pol2qm74	1810	7	to	to	IN
cord-015021-pol2qm74	1810	8	104U	104u	CD
cord-015021-pol2qm74	1811	1	/ml	/ml	.
cord-015021-pol2qm74	1811	2	(	(	-LRB-
cord-015021-pol2qm74	1812	1	as	as	IN
cord-015021-pol2qm74	1812	2	detected	detect	VBN
cord-015021-pol2qm74	1812	3	in	in	IN
cord-015021-pol2qm74	1812	4	fluids	fluid	NNS
cord-015021-pol2qm74	1812	5	derived	derive	VBN
cord-015021-pol2qm74	1812	6	from	from	IN
cord-015021-pol2qm74	1812	7	local	local	JJ
cord-015021-pol2qm74	1812	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1812	9	site	site	NN
cord-015021-pol2qm74	1812	10	)	)	-RRB-
cord-015021-pol2qm74	1812	11	were	be	VBD
cord-015021-pol2qm74	1812	12	found	find	VBN
cord-015021-pol2qm74	1812	13	to	to	TO
cord-015021-pol2qm74	1812	14	be	be	VB
cord-015021-pol2qm74	1812	15	capable	capable	JJ
cord-015021-pol2qm74	1812	16	to	to	TO
cord-015021-pol2qm74	1812	17	induce	induce	VB
cord-015021-pol2qm74	1812	18	a	a	DT
cord-015021-pol2qm74	1812	19	significant	significant	JJ
cord-015021-pol2qm74	1812	20	release	release	NN
cord-015021-pol2qm74	1812	21	of	of	IN
cord-015021-pol2qm74	1812	22	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	1812	23	elastase	elastase	NN
cord-015021-pol2qm74	1812	24	in	in	IN
cord-015021-pol2qm74	1812	25	a	a	DT
cord-015021-pol2qm74	1812	26	concentration	concentration	NN
cord-015021-pol2qm74	1812	27	-	-	HYPH
cord-015021-pol2qm74	1812	28	dependent	dependent	JJ
cord-015021-pol2qm74	1812	29	manner	manner	NN
cord-015021-pol2qm74	1812	30	,	,	,
cord-015021-pol2qm74	1812	31	whereas	whereas	IN
cord-015021-pol2qm74	1812	32	the	the	DT
cord-015021-pol2qm74	1812	33	degranulation	degranulation	NN
cord-015021-pol2qm74	1812	34	of	of	IN
cord-015021-pol2qm74	1812	35	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1812	36	was	be	VBD
cord-015021-pol2qm74	1812	37	uneffected	uneffecte	VBN
cord-015021-pol2qm74	1812	38	by	by	IN
cord-015021-pol2qm74	1812	39	TGF-61	TGF-61	NNP
cord-015021-pol2qm74	1812	40	.	.	.
cord-015021-pol2qm74	1813	1	In	in	IN
cord-015021-pol2qm74	1813	2	conclusion	conclusion	NN
cord-015021-pol2qm74	1813	3	,	,	,
cord-015021-pol2qm74	1813	4	these	these	DT
cord-015021-pol2qm74	1813	5	data	datum	NNS
cord-015021-pol2qm74	1813	6	suggest	suggest	VBP
cord-015021-pol2qm74	1813	7	a	a	DT
cord-015021-pol2qm74	1813	8	contribution	contribution	NN
cord-015021-pol2qm74	1813	9	of	of	IN
cord-015021-pol2qm74	1813	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	1813	11	in	in	IN
cord-015021-pol2qm74	1813	12	regulation	regulation	NN
cord-015021-pol2qm74	1813	13	of	of	IN
cord-015021-pol2qm74	1813	14	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1813	15	activation	activation	NN
cord-015021-pol2qm74	1813	16	at	at	IN
cord-015021-pol2qm74	1813	17	sides	side	NNS
cord-015021-pol2qm74	1813	18	of	of	IN
cord-015021-pol2qm74	1813	19	inflammation	inflammation	NN
cord-015021-pol2qm74	1813	20	.	.	.
cord-015021-pol2qm74	1814	1	The	the	DT
cord-015021-pol2qm74	1814	2	immunosuppressive	immunosuppressive	JJ
cord-015021-pol2qm74	1814	3	cytokine	cytokine	NN
cord-015021-pol2qm74	1814	4	TGF	TGF	NNP
cord-015021-pol2qm74	1814	5	-	-	HYPH
cord-015021-pol2qm74	1814	6	I&~	I&~	NNP
cord-015021-pol2qm74	1814	7	seems	seem	VBZ
cord-015021-pol2qm74	1814	8	to	to	TO
cord-015021-pol2qm74	1814	9	have	have	VB
cord-015021-pol2qm74	1814	10	no	no	DT
cord-015021-pol2qm74	1814	11	direct	direct	JJ
cord-015021-pol2qm74	1814	12	regulatory	regulatory	JJ
cord-015021-pol2qm74	1814	13	effect	effect	NN
cord-015021-pol2qm74	1814	14	beside	beside	IN
cord-015021-pol2qm74	1814	15	its	-PRON-	PRP$
cord-015021-pol2qm74	1814	16	described	described	JJ
cord-015021-pol2qm74	1814	17	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	1814	18	function	function	NN
cord-015021-pol2qm74	1814	19	on	on	IN
cord-015021-pol2qm74	1814	20	neutrephils	neutrephils	NNP
cord-015021-pol2qm74	1814	21	.	.	.
cord-015021-pol2qm74	1815	1	Postirradiation	Postirradiation	NNP
cord-015021-pol2qm74	1815	2	chan	chan	NNP
cord-015021-pol2qm74	1815	3	~	~	NFP
cord-015021-pol2qm74	1815	4	es	es	NNP
cord-015021-pol2qm74	1815	5	of	of	IN
cord-015021-pol2qm74	1815	6	adhesive	adhesive	JJ
cord-015021-pol2qm74	1815	7	properties	property	NNS
cord-015021-pol2qm74	1815	8	arid	arid	JJ
cord-015021-pol2qm74	1815	9	supercoiled	supercoile	VBN
cord-015021-pol2qm74	1815	10	nucleoid	nucleoid	NNP
cord-015021-pol2qm74	1815	11	DNA	DNA	NNP
cord-015021-pol2qm74	1815	12	structure	structure	NN
cord-015021-pol2qm74	1815	13	of	of	IN
cord-015021-pol2qm74	1815	14	blood	blood	NN
cord-015021-pol2qm74	1815	15	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1815	16	were	be	VBD
cord-015021-pol2qm74	1815	17	studied	study	VBN
cord-015021-pol2qm74	1815	18	in	in	IN
cord-015021-pol2qm74	1815	19	Macaca	Macaca	NNP
cord-015021-pol2qm74	1815	20	nemestrina	nemestrina	NNP
cord-015021-pol2qm74	1815	21	andrats	andrat	NNS
cord-015021-pol2qm74	1815	22	.	.	.
cord-015021-pol2qm74	1816	1	The	the	DT
cord-015021-pol2qm74	1816	2	dynamics	dynamic	NNS
cord-015021-pol2qm74	1816	3	of	of	IN
cord-015021-pol2qm74	1816	4	membrane	membrane	NN
cord-015021-pol2qm74	1816	5	chan	chan	NNP
cord-015021-pol2qm74	1816	6	~	~	NFP
cord-015021-pol2qm74	1816	7	es	es	XX
cord-015021-pol2qm74	1816	8	after	after	IN
cord-015021-pol2qm74	1816	9	nonlethal	nonlethal	JJ
cord-015021-pol2qm74	1816	10	irradiation	irradiation	NN
cord-015021-pol2qm74	1816	11	of	of	IN
cord-015021-pol2qm74	1816	12	rats	rat	NNS
cord-015021-pol2qm74	1816	13	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	1816	14	the	the	DT
cord-015021-pol2qm74	1816	15	temporary	temporary	JJ
cord-015021-pol2qm74	1816	16	increase	increase	NN
cord-015021-pol2qm74	1816	17	of	of	IN
cord-015021-pol2qm74	1816	18	the	the	DT
cord-015021-pol2qm74	1816	19	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1816	20	adherence	adherence	NN
cord-015021-pol2qm74	1816	21	at	at	IN
cord-015021-pol2qm74	1816	22	24	24	CD
cord-015021-pol2qm74	1816	23	h	h	NN
cord-015021-pol2qm74	1816	24	followed	follow	VBN
cord-015021-pol2qm74	1816	25	by	by	IN
cord-015021-pol2qm74	1816	26	return	return	NN
cord-015021-pol2qm74	1816	27	of	of	IN
cord-015021-pol2qm74	1816	28	this	this	DT
cord-015021-pol2qm74	1816	29	parameter	parameter	NN
cord-015021-pol2qm74	1816	30	to	to	IN
cord-015021-pol2qm74	1816	31	normal	normal	JJ
cord-015021-pol2qm74	1816	32	levels	level	NNS
cord-015021-pol2qm74	1816	33	at	at	IN
cord-015021-pol2qm74	1816	34	48	48	CD
cord-015021-pol2qm74	1816	35	h.	h.	NN
cord-015021-pol2qm74	1817	1	After	after	IN
cord-015021-pol2qm74	1817	2	lethal	lethal	JJ
cord-015021-pol2qm74	1817	3	irradiation	irradiation	NN
cord-015021-pol2qm74	1817	4	of	of	IN
cord-015021-pol2qm74	1817	5	both	both	DT
cord-015021-pol2qm74	1817	6	animal	animal	NN
cord-015021-pol2qm74	1817	7	species	species	VBP
cord-015021-pol2qm74	1817	8	the	the	DT
cord-015021-pol2qm74	1817	9	increase	increase	NN
cord-015021-pol2qm74	1817	10	in	in	IN
cord-015021-pol2qm74	1817	11	adhesive	adhesive	JJ
cord-015021-pol2qm74	1817	12	leukooytes	leukooytes	NNP
cord-015021-pol2qm74	1817	13	fraction	fraction	NN
cord-015021-pol2qm74	1817	14	was	be	VBD
cord-015021-pol2qm74	1817	15	detected	detect	VBN
cord-015021-pol2qm74	1817	16	as	as	RB
cord-015021-pol2qm74	1817	17	early	early	RB
cord-015021-pol2qm74	1817	18	as	as	IN
cord-015021-pol2qm74	1817	19	at	at	IN
cord-015021-pol2qm74	1817	20	3	3	CD
cord-015021-pol2qm74	1817	21	h.	h.	NN
cord-015021-pol2qm74	1818	1	This	this	DT
cord-015021-pol2qm74	1819	1	hi	hi	UH
cord-015021-pol2qm74	1820	1	~her	~her	NNP
cord-015021-pol2qm74	1820	2	index	index	NN
cord-015021-pol2qm74	1820	3	persisted	persist	VBD
cord-015021-pol2qm74	1820	4	until	until	IN
cord-015021-pol2qm74	1820	5	the	the	DT
cord-015021-pol2qm74	1820	6	end	end	NN
cord-015021-pol2qm74	1820	7	of	of	IN
cord-015021-pol2qm74	1820	8	experiments	experiment	NNS
cord-015021-pol2qm74	1820	9	(	(	-LRB-
cord-015021-pol2qm74	1820	10	5	5	CD
cord-015021-pol2qm74	1820	11	days	day	NNS
cord-015021-pol2qm74	1820	12	)	)	-RRB-
cord-015021-pol2qm74	1820	13	.	.	.
cord-015021-pol2qm74	1821	1	The	the	DT
cord-015021-pol2qm74	1821	2	early	early	JJ
cord-015021-pol2qm74	1821	3	(	(	-LRB-
cord-015021-pol2qm74	1821	4	3	3	CD
cord-015021-pol2qm74	1821	5	-	-	HYPH
cord-015021-pol2qm74	1821	6	5h	5h	LS
cord-015021-pol2qm74	1821	7	)	)	-RRB-
cord-015021-pol2qm74	1821	8	temporary	temporary	JJ
cord-015021-pol2qm74	1821	9	loosin~	loosin~	NNP
cord-015021-pol2qm74	1821	10	of	of	IN
cord-015021-pol2qm74	1821	11	supercoiled	supercoiled	JJ
cord-015021-pol2qm74	1821	12	DNA	dna	NN
cord-015021-pol2qm74	1821	13	structure	structure	NN
cord-015021-pol2qm74	1821	14	was	be	VBD
cord-015021-pol2qm74	1821	15	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	1821	16	in	in	IN
cord-015021-pol2qm74	1821	17	the	the	DT
cord-015021-pol2qm74	1821	18	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1821	19	of	of	IN
cord-015021-pol2qm74	1821	20	nonlethally	nonlethally	RB
cord-015021-pol2qm74	1821	21	irradiated	irradiate	VBN
cord-015021-pol2qm74	1821	22	animals	animal	NNS
cord-015021-pol2qm74	1821	23	.	.	.
cord-015021-pol2qm74	1822	1	This	this	DT
cord-015021-pol2qm74	1822	2	phenomenon	phenomenon	NN
cord-015021-pol2qm74	1822	3	seems	seem	VBZ
cord-015021-pol2qm74	1822	4	to	to	TO
cord-015021-pol2qm74	1822	5	be	be	VB
cord-015021-pol2qm74	1822	6	connected	connect	VBN
cord-015021-pol2qm74	1822	7	with	with	IN
cord-015021-pol2qm74	1822	8	the	the	DT
cord-015021-pol2qm74	1822	9	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	1822	10	fraction	fraction	NN
cord-015021-pol2qm74	1822	11	chan~	chan~	NNP
cord-015021-pol2qm74	1823	1	es	es	NNP
cord-015021-pol2qm74	1823	2	.	.	.
cord-015021-pol2qm74	1824	1	This	this	DT
cord-015021-pol2qm74	1824	2	process	process	NN
cord-015021-pol2qm74	1824	3	was	be	VBD
cord-015021-pol2qm74	1824	4	not	not	RB
cord-015021-pol2qm74	1824	5	dependent	dependent	JJ
cord-015021-pol2qm74	1824	6	on	on	IN
cord-015021-pol2qm74	1824	7	altered	altered	JJ
cord-015021-pol2qm74	1824	8	adhesive	adhesive	JJ
cord-015021-pol2qm74	1824	9	properties	property	NNS
cord-015021-pol2qm74	1824	10	of	of	IN
cord-015021-pol2qm74	1824	11	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1824	12	membranes	membrane	NNS
cord-015021-pol2qm74	1824	13	.	.	.
cord-015021-pol2qm74	1825	1	The	the	DT
cord-015021-pol2qm74	1825	2	membrane	membrane	NN
cord-015021-pol2qm74	1825	3	chan	chan	NNP
cord-015021-pol2qm74	1825	4	~	~	NFP
cord-015021-pol2qm74	1825	5	es	es	XX
cord-015021-pol2qm74	1825	6	of	of	IN
cord-015021-pol2qm74	1825	7	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1825	8	preceded	precede	VBD
cord-015021-pol2qm74	1825	9	decondensation	decondensation	NN
cord-015021-pol2qm74	1825	10	of	of	IN
cord-015021-pol2qm74	1825	11	supercoiled	supercoiled	JJ
cord-015021-pol2qm74	1825	12	DNA	dna	NN
cord-015021-pol2qm74	1825	13	after	after	IN
cord-015021-pol2qm74	1825	14	lethal	lethal	JJ
cord-015021-pol2qm74	1825	15	irradiation	irradiation	NN
cord-015021-pol2qm74	1825	16	of	of	IN
cord-015021-pol2qm74	1825	17	animals	animal	NNS
cord-015021-pol2qm74	1825	18	,	,	.
cord-015021-pol2qm74	1826	1	In	in	IN
cord-015021-pol2qm74	1826	2	this	this	DT
cord-015021-pol2qm74	1826	3	case	case	NN
cord-015021-pol2qm74	1826	4	loosin~	loosin~	NNP
cord-015021-pol2qm74	1826	5	of	of	IN
cord-015021-pol2qm74	1826	6	supercoiled	supercoiled	JJ
cord-015021-pol2qm74	1826	7	DNA	DNA	NNP
cord-015021-pol2qm74	1826	8	pro-~ressively	pro-~ressively	NN
cord-015021-pol2qm74	1826	9	increased	increase	VBD
cord-015021-pol2qm74	1826	10	at	at	IN
cord-015021-pol2qm74	1826	11	24	24	CD
cord-015021-pol2qm74	1826	12	h	h	NN
cord-015021-pol2qm74	1826	13	and	and	CC
cord-015021-pol2qm74	1826	14	at	at	IN
cord-015021-pol2qm74	1826	15	the	the	DT
cord-015021-pol2qm74	1826	16	later	later	JJ
cord-015021-pol2qm74	1826	17	terms	term	NNS
cord-015021-pol2qm74	1826	18	of	of	IN
cord-015021-pol2qm74	1826	19	postirradiation	postirradiation	NN
cord-015021-pol2qm74	1826	20	period	period	NN
cord-015021-pol2qm74	1826	21	.	.	.
cord-015021-pol2qm74	1827	1	The	the	DT
cord-015021-pol2qm74	1827	2	systemic	systemic	JJ
cord-015021-pol2qm74	1827	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1827	4	response	response	NN
cord-015021-pol2qm74	1827	5	syndrome	syndrome	NN
cord-015021-pol2qm74	1827	6	(	(	-LRB-
cord-015021-pol2qm74	1827	7	SIRS	SIRS	NNP
cord-015021-pol2qm74	1827	8	)	)	-RRB-
cord-015021-pol2qm74	1827	9	involves	involve	VBZ
cord-015021-pol2qm74	1827	10	many	many	JJ
cord-015021-pol2qm74	1827	11	inanunological	inanunological	JJ
cord-015021-pol2qm74	1827	12	reactions	reaction	NNS
cord-015021-pol2qm74	1827	13	of	of	IN
cord-015021-pol2qm74	1827	14	the	the	DT
cord-015021-pol2qm74	1827	15	host	host	NN
cord-015021-pol2qm74	1827	16	including	include	VBG
cord-015021-pol2qm74	1827	17	acfivatinn	acfivatinn	NNP
cord-015021-pol2qm74	1827	18	of	of	IN
cord-015021-pol2qm74	1827	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1827	20	mediator	mediator	NN
cord-015021-pol2qm74	1827	21	cascades	cascade	NNS
cord-015021-pol2qm74	1827	22	and	and	CC
cord-015021-pol2qm74	1827	23	depression	depression	NN
cord-015021-pol2qm74	1827	24	of	of	IN
cord-015021-pol2qm74	1827	25	cellular	cellular	JJ
cord-015021-pol2qm74	1827	26	reactivity	reactivity	NN
cord-015021-pol2qm74	1827	27	in	in	IN
cord-015021-pol2qm74	1827	28	T	T	NNP
cord-015021-pol2qm74	1827	29	-	-	HYPH
cord-015021-pol2qm74	1827	30	lymphecytes	lymphecytes	NNPS
cord-015021-pol2qm74	1827	31	(	(	-LRB-
cord-015021-pol2qm74	1827	32	1	1	CD
cord-015021-pol2qm74	1827	33	)	)	-RRB-
cord-015021-pol2qm74	1827	34	.	.	.
cord-015021-pol2qm74	1828	1	There	there	EX
cord-015021-pol2qm74	1828	2	are	be	VBP
cord-015021-pol2qm74	1828	3	reports	report	NNS
cord-015021-pol2qm74	1828	4	of	of	IN
cord-015021-pol2qm74	1828	5	nentrophil	nentrophil	JJ
cord-015021-pol2qm74	1828	6	dysfunction	dysfunction	NN
cord-015021-pol2qm74	1828	7	in	in	IN
cord-015021-pol2qm74	1828	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1828	9	disorders	disorder	NNS
cord-015021-pol2qm74	1828	10	of	of	IN
cord-015021-pol2qm74	1828	11	the	the	DT
cord-015021-pol2qm74	1828	12	skin	skin	NN
cord-015021-pol2qm74	1828	13	(	(	-LRB-
cord-015021-pol2qm74	1828	14	2	2	CD
cord-015021-pol2qm74	1828	15	)	)	-RRB-
cord-015021-pol2qm74	1828	16	,	,	,
cord-015021-pol2qm74	1828	17	Are	be	VBP
cord-015021-pol2qm74	1828	18	there	there	EX
cord-015021-pol2qm74	1828	19	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	1828	20	concerning	concern	VBG
cord-015021-pol2qm74	1828	21	the	the	DT
cord-015021-pol2qm74	1828	22	unspecific	unspecific	JJ
cord-015021-pol2qm74	1828	23	host	host	NN
cord-015021-pol2qm74	1828	24	defense	defense	NN
cord-015021-pol2qm74	1828	25	in	in	IN
cord-015021-pol2qm74	1828	26	SIRS	SIRS	NNP
cord-015021-pol2qm74	1828	27	,	,	,
cord-015021-pol2qm74	1828	28	as	as	RB
cord-015021-pol2qm74	1828	29	well	well	RB
cord-015021-pol2qm74	1828	30	?	?	.
cord-015021-pol2qm74	1829	1	In	in	IN
cord-015021-pol2qm74	1829	2	this	this	DT
cord-015021-pol2qm74	1829	3	study	study	NN
cord-015021-pol2qm74	1829	4	,	,	,
cord-015021-pol2qm74	1829	5	we	-PRON-	PRP
cord-015021-pol2qm74	1829	6	examined	examine	VBD
cord-015021-pol2qm74	1829	7	the	the	DT
cord-015021-pol2qm74	1829	8	reactivity	reactivity	NN
cord-015021-pol2qm74	1829	9	of	of	IN
cord-015021-pol2qm74	1829	10	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1829	11	granolocytes	granolocyte	NNS
cord-015021-pol2qm74	1829	12	from	from	IN
cord-015021-pol2qm74	1829	13	patients	patient	NNS
cord-015021-pol2qm74	1829	14	suffering	suffer	VBG
cord-015021-pol2qm74	1829	15	from	from	IN
cord-015021-pol2qm74	1829	16	SIRS	SIRS	NNP
cord-015021-pol2qm74	1829	17	.	.	.
cord-015021-pol2qm74	1830	1	Twenty	twenty	CD
cord-015021-pol2qm74	1830	2	-	-	HYPH
cord-015021-pol2qm74	1830	3	one	one	CD
cord-015021-pol2qm74	1830	4	patients	patient	NNS
cord-015021-pol2qm74	1830	5	(	(	-LRB-
cord-015021-pol2qm74	1830	6	APACHE	APACHE	NNP
cord-015021-pol2qm74	1830	7	II	II	NNP
cord-015021-pol2qm74	1830	8	-	-	HYPH
cord-015021-pol2qm74	1830	9	score	score	NN
cord-015021-pol2qm74	1830	10	21±5	21±5	CD
cord-015021-pol2qm74	1830	11	)	)	-RRB-
cord-015021-pol2qm74	1830	12	with	with	IN
cord-015021-pol2qm74	1830	13	diagnosis	diagnosis	NN
cord-015021-pol2qm74	1830	14	of	of	IN
cord-015021-pol2qm74	1830	15	SIRS	SIRS	NNP
cord-015021-pol2qm74	1830	16	entered	enter	VBD
cord-015021-pol2qm74	1830	17	the	the	DT
cord-015021-pol2qm74	1830	18	study	study	NN
cord-015021-pol2qm74	1830	19	.	.	.
cord-015021-pol2qm74	1831	1	Granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1831	2	were	be	VBD
cord-015021-pol2qm74	1831	3	prepared	prepare	VBN
cord-015021-pol2qm74	1831	4	as	as	IN
cord-015021-pol2qm74	1831	5	reported	report	VBN
cord-015021-pol2qm74	1831	6	previously	previously	RB
cord-015021-pol2qm74	1831	7	(	(	-LRB-
cord-015021-pol2qm74	1831	8	2	2	CD
cord-015021-pol2qm74	1831	9	)	)	-RRB-
cord-015021-pol2qm74	1831	10	.	.	.
cord-015021-pol2qm74	1832	1	In	in	IN
cord-015021-pol2qm74	1832	2	parallel	parallel	NN
cord-015021-pol2qm74	1832	3	,	,	,
cord-015021-pol2qm74	1832	4	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1832	5	from	from	IN
cord-015021-pol2qm74	1832	6	20	20	CD
cord-015021-pol2qm74	1832	7	healthy	healthy	JJ
cord-015021-pol2qm74	1832	8	individuals	individual	NNS
cord-015021-pol2qm74	1832	9	were	be	VBD
cord-015021-pol2qm74	1832	10	tested	test	VBN
cord-015021-pol2qm74	1832	11	.	.	.
cord-015021-pol2qm74	1833	1	Two	two	CD
cord-015021-pol2qm74	1833	2	granulocyte	granulocyte	NN
cord-015021-pol2qm74	1833	3	functians	functian	NNS
cord-015021-pol2qm74	1833	4	were	be	VBD
cord-015021-pol2qm74	1833	5	studied	study	VBN
cord-015021-pol2qm74	1833	6	in	in	IN
cord-015021-pol2qm74	1833	7	vitro	vitro	FW
cord-015021-pol2qm74	1833	8	:	:	:
cord-015021-pol2qm74	1833	9	1	1	CD
cord-015021-pol2qm74	1833	10	.	.	.
cord-015021-pol2qm74	1834	1	Migration	migration	NN
cord-015021-pol2qm74	1834	2	of	of	IN
cord-015021-pol2qm74	1834	3	the	the	DT
cord-015021-pol2qm74	1834	4	ceils	ceil	NNS
cord-015021-pol2qm74	1834	5	in	in	IN
cord-015021-pol2qm74	1834	6	a	a	DT
cord-015021-pol2qm74	1834	7	boyden	boyden	NNP
cord-015021-pol2qm74	1834	8	chamber	chamber	NN
cord-015021-pol2qm74	1834	9	through	through	IN
cord-015021-pol2qm74	1834	10	a	a	DT
cord-015021-pol2qm74	1834	11	filter	filter	NN
cord-015021-pol2qm74	1834	12	matrix	matrix	NN
cord-015021-pol2qm74	1834	13	following	follow	VBG
cord-015021-pol2qm74	1834	14	stimulation	stimulation	NN
cord-015021-pol2qm74	1834	15	with	with	IN
cord-015021-pol2qm74	1834	16	5	5	CD
cord-015021-pol2qm74	1834	17	different	different	JJ
cord-015021-pol2qm74	1834	18	receptor	receptor	NN
cord-015021-pol2qm74	1834	19	dependent	dependent	JJ
cord-015021-pol2qm74	1834	20	stimuli	stimulus	NNS
cord-015021-pol2qm74	1834	21	(	(	-LRB-
cord-015021-pol2qm74	1834	22	C5a	C5a	NNS
cord-015021-pol2qm74	1834	23	,	,	,
cord-015021-pol2qm74	1834	24	Intefleukin-8	Intefleukin-8	NNP
cord-015021-pol2qm74	1834	25	,	,	,
cord-015021-pol2qm74	1834	26	Platelet	platelet	NN
cord-015021-pol2qm74	1834	27	-	-	HYPH
cord-015021-pol2qm74	1834	28	activating	activate	VBG
cord-015021-pol2qm74	1834	29	-	-	HYPH
cord-015021-pol2qm74	1834	30	factor	factor	NN
cord-015021-pol2qm74	1834	31	,	,	,
cord-015021-pol2qm74	1834	32	Leukotrien	Leukotrien	NNP
cord-015021-pol2qm74	1834	33	B4	B4	NNP
cord-015021-pol2qm74	1834	34	,	,	,
cord-015021-pol2qm74	1834	35	FMLP	FMLP	NNP
cord-015021-pol2qm74	1834	36	)	)	-RRB-
cord-015021-pol2qm74	1834	37	.	.	.
cord-015021-pol2qm74	1835	1	2	2	LS
cord-015021-pol2qm74	1835	2	.	.	.
cord-015021-pol2qm74	1836	1	Release	release	NN
cord-015021-pol2qm74	1836	2	of	of	IN
cord-015021-pol2qm74	1836	3	13glucuronidase	13glucuronidase	CD
cord-015021-pol2qm74	1836	4	following	follow	VBG
cord-015021-pol2qm74	1836	5	stimulation	stimulation	NN
cord-015021-pol2qm74	1836	6	with	with	IN
cord-015021-pol2qm74	1836	7	the	the	DT
cord-015021-pol2qm74	1836	8	aforementioned	aforementioned	JJ
cord-015021-pol2qm74	1836	9	activators	activator	NNS
cord-015021-pol2qm74	1836	10	.	.	.
cord-015021-pol2qm74	1837	1	The	the	DT
cord-015021-pol2qm74	1837	2	results	result	NNS
cord-015021-pol2qm74	1837	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	1837	4	,	,	,
cord-015021-pol2qm74	1837	5	that	that	IN
cord-015021-pol2qm74	1837	6	the	the	DT
cord-015021-pol2qm74	1837	7	release	release	NN
cord-015021-pol2qm74	1837	8	of	of	IN
cord-015021-pol2qm74	1837	9	13-glucuronidase	13-glucuronidase	CD
cord-015021-pol2qm74	1837	10	in	in	IN
cord-015021-pol2qm74	1837	11	patients	patient	NNS
cord-015021-pol2qm74	1837	12	suffering	suffer	VBG
cord-015021-pol2qm74	1837	13	from	from	IN
cord-015021-pol2qm74	1837	14	SIRS	SIRS	NNP
cord-015021-pol2qm74	1837	15	was	be	VBD
cord-015021-pol2qm74	1837	16	comparable	comparable	JJ
cord-015021-pol2qm74	1837	17	to	to	IN
cord-015021-pol2qm74	1837	18	the	the	DT
cord-015021-pol2qm74	1837	19	enzyme	enzyme	NN
cord-015021-pol2qm74	1837	20	release	release	NN
cord-015021-pol2qm74	1837	21	of	of	IN
cord-015021-pol2qm74	1837	22	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1837	23	prepared	prepare	VBN
cord-015021-pol2qm74	1837	24	from	from	IN
cord-015021-pol2qm74	1837	25	healthy	healthy	JJ
cord-015021-pol2qm74	1837	26	individuals	individual	NNS
cord-015021-pol2qm74	1837	27	.	.	.
cord-015021-pol2qm74	1838	1	Each	each	DT
cord-015021-pol2qm74	1838	2	stimulant	stimulant	NN
cord-015021-pol2qm74	1838	3	induced	induce	VBN
cord-015021-pol2qm74	1838	4	release	release	NN
cord-015021-pol2qm74	1838	5	of	of	IN
cord-015021-pol2qm74	1838	6	p	p	NN
cord-015021-pol2qm74	1838	7	-	-	HYPH
cord-015021-pol2qm74	1838	8	glucuronidase	glucuronidase	NN
cord-015021-pol2qm74	1838	9	in	in	IN
cord-015021-pol2qm74	1838	10	a	a	DT
cord-015021-pol2qm74	1838	11	characteristic	characteristic	JJ
cord-015021-pol2qm74	1838	12	dose	dose	NN
cord-015021-pol2qm74	1838	13	dependent	dependent	JJ
cord-015021-pol2qm74	1838	14	fashion	fashion	NN
cord-015021-pol2qm74	1838	15	.	.	.
cord-015021-pol2qm74	1839	1	All	all	DT
cord-015021-pol2qm74	1839	2	granulocyte	granulocyte	NN
cord-015021-pol2qm74	1839	3	preparations	preparation	NNS
cord-015021-pol2qm74	1839	4	from	from	IN
cord-015021-pol2qm74	1839	5	the	the	DT
cord-015021-pol2qm74	1839	6	healthy	healthy	JJ
cord-015021-pol2qm74	1839	7	donors	donor	NNS
cord-015021-pol2qm74	1839	8	showed	show	VBD
cord-015021-pol2qm74	1839	9	a	a	DT
cord-015021-pol2qm74	1839	10	positive	positive	JJ
cord-015021-pol2qm74	1839	11	chemotaxis	chemotaxis	NN
cord-015021-pol2qm74	1839	12	response	response	NN
cord-015021-pol2qm74	1839	13	in	in	IN
cord-015021-pol2qm74	1839	14	the	the	DT
cord-015021-pol2qm74	1839	15	migration	migration	NN
cord-015021-pol2qm74	1839	16	-	-	HYPH
cord-015021-pol2qm74	1839	17	assay	assay	NN
cord-015021-pol2qm74	1839	18	.	.	.
cord-015021-pol2qm74	1840	1	In	in	IN
cord-015021-pol2qm74	1840	2	contrast	contrast	NN
cord-015021-pol2qm74	1840	3	,	,	,
cord-015021-pol2qm74	1840	4	only	only	RB
cord-015021-pol2qm74	1840	5	ten	ten	CD
cord-015021-pol2qm74	1840	6	out	out	IN
cord-015021-pol2qm74	1840	7	of	of	IN
cord-015021-pol2qm74	1840	8	twenty	twenty	CD
cord-015021-pol2qm74	1840	9	-	-	HYPH
cord-015021-pol2qm74	1840	10	one	one	CD
cord-015021-pol2qm74	1840	11	patients	patient	NNS
cord-015021-pol2qm74	1840	12	had	have	VBD
cord-015021-pol2qm74	1840	13	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1840	14	migrating	migrate	VBG
cord-015021-pol2qm74	1840	15	after	after	IN
cord-015021-pol2qm74	1840	16	stimulation	stimulation	NN
cord-015021-pol2qm74	1840	17	.	.	.
cord-015021-pol2qm74	1841	1	The	the	DT
cord-015021-pol2qm74	1841	2	two	two	CD
cord-015021-pol2qm74	1841	3	groups	group	NNS
cord-015021-pol2qm74	1841	4	of	of	IN
cord-015021-pol2qm74	1841	5	patients	patient	NNS
cord-015021-pol2qm74	1841	6	displaying	display	VBG
cord-015021-pol2qm74	1841	7	reactive	reactive	JJ
cord-015021-pol2qm74	1841	8	or	or	CC
cord-015021-pol2qm74	1841	9	non	non	JJ
cord-015021-pol2qm74	1841	10	-	-	JJ
cord-015021-pol2qm74	1841	11	reactive	reactive	JJ
cord-015021-pol2qm74	1841	12	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1841	13	differed	differ	VBD
cord-015021-pol2qm74	1841	14	clinically	clinically	RB
cord-015021-pol2qm74	1841	15	:	:	:
cord-015021-pol2qm74	1841	16	The	the	DT
cord-015021-pol2qm74	1841	17	nonreactive	nonreactive	JJ
cord-015021-pol2qm74	1841	18	group	group	NN
cord-015021-pol2qm74	1841	19	consisted	consist	VBD
cord-015021-pol2qm74	1841	20	of	of	IN
cord-015021-pol2qm74	1841	21	patients	patient	NNS
cord-015021-pol2qm74	1841	22	with	with	IN
cord-015021-pol2qm74	1841	23	multiple	multiple	JJ
cord-015021-pol2qm74	1841	24	organ	organ	NN
cord-015021-pol2qm74	1841	25	failure	failure	NN
cord-015021-pol2qm74	1841	26	(	(	-LRB-
cord-015021-pol2qm74	1841	27	10/11	10/11	CD
cord-015021-pol2qm74	1841	28	)	)	-RRB-
cord-015021-pol2qm74	1841	29	and	and	CC
cord-015021-pol2qm74	1841	30	nonsurvivors	nonsurvivors	NNP
cord-015021-pol2qm74	1841	31	(	(	-LRB-
cord-015021-pol2qm74	1841	32	8/11	8/11	CD
cord-015021-pol2qm74	1841	33	)	)	-RRB-
cord-015021-pol2qm74	1841	34	,	,	,
cord-015021-pol2qm74	1841	35	whereas	whereas	IN
cord-015021-pol2qm74	1841	36	8/10	8/10	CD
cord-015021-pol2qm74	1841	37	patients	patient	NNS
cord-015021-pol2qm74	1841	38	in	in	IN
cord-015021-pol2qm74	1841	39	the	the	DT
cord-015021-pol2qm74	1841	40	reactive	reactive	JJ
cord-015021-pol2qm74	1841	41	group	group	NN
cord-015021-pol2qm74	1841	42	survived	survive	VBD
cord-015021-pol2qm74	1841	43	.	.	.
cord-015021-pol2qm74	1842	1	Thus	thus	RB
cord-015021-pol2qm74	1842	2	,	,	,
cord-015021-pol2qm74	1842	3	the	the	DT
cord-015021-pol2qm74	1842	4	in	in	FW
cord-015021-pol2qm74	1842	5	vitro	vitro	FW
cord-015021-pol2qm74	1842	6	chemotaxis	chemotaxis	NN
cord-015021-pol2qm74	1842	7	of	of	IN
cord-015021-pol2qm74	1842	8	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	1842	9	is	be	VBZ
cord-015021-pol2qm74	1842	10	impaired	impair	VBN
cord-015021-pol2qm74	1842	11	in	in	IN
cord-015021-pol2qm74	1842	12	a	a	DT
cord-015021-pol2qm74	1842	13	subgroup	subgroup	NN
cord-015021-pol2qm74	1842	14	of	of	IN
cord-015021-pol2qm74	1842	15	patients	patient	NNS
cord-015021-pol2qm74	1842	16	with	with	IN
cord-015021-pol2qm74	1842	17	SIRS	SIRS	NNP
cord-015021-pol2qm74	1842	18	.	.	.
cord-015021-pol2qm74	1843	1	This	this	DT
cord-015021-pol2qm74	1843	2	defect	defect	NN
cord-015021-pol2qm74	1843	3	of	of	IN
cord-015021-pol2qm74	1843	4	the	the	DT
cord-015021-pol2qm74	1843	5	non	non	JJ
cord-015021-pol2qm74	1843	6	-	-	JJ
cord-015021-pol2qm74	1843	7	specific	specific	JJ
cord-015021-pol2qm74	1843	8	host	host	NN
cord-015021-pol2qm74	1843	9	defense	defense	NN
cord-015021-pol2qm74	1843	10	may	may	MD
cord-015021-pol2qm74	1843	11	contribute	contribute	VB
cord-015021-pol2qm74	1843	12	to	to	IN
cord-015021-pol2qm74	1843	13	poor	poor	JJ
cord-015021-pol2qm74	1843	14	prognosis	prognosis	NN
cord-015021-pol2qm74	1843	15	and	and	CC
cord-015021-pol2qm74	1843	16	outcome	outcome	NN
cord-015021-pol2qm74	1843	17	of	of	IN
cord-015021-pol2qm74	1843	18	these	these	DT
cord-015021-pol2qm74	1843	19	patients	patient	NNS
cord-015021-pol2qm74	1843	20	.	.	.
cord-015021-pol2qm74	1844	1	Dermatol	Dermatol	NNP
cord-015021-pol2qm74	1844	2	.	.	.
cord-015021-pol2qm74	1845	1	85	85	CD
cord-015021-pol2qm74	1845	2	:	:	:
cord-015021-pol2qm74	1845	3	194	194	CD
cord-015021-pol2qm74	1845	4	-	-	SYM
cord-015021-pol2qm74	1845	5	198	198	CD
cord-015021-pol2qm74	1845	6	,	,	,
cord-015021-pol2qm74	1845	7	1985	1985	CD
cord-015021-pol2qm74	1845	8	Klinik	Klinik	NNP
cord-015021-pol2qm74	1845	9	ffir	ffir	NN
cord-015021-pol2qm74	1845	10	An~	An~	NNP
cord-015021-pol2qm74	1846	1	isthesiologie	isthesiologie	NNP
cord-015021-pol2qm74	1846	2	und	und	NNP
cord-015021-pol2qm74	1847	1	Operative	Operative	NNP
cord-015021-pol2qm74	1847	2	Intensivmedizin	Intensivmedizin	NNP
cord-015021-pol2qm74	1847	3	der	der	NNP
cord-015021-pol2qm74	1847	4	CAU	CAU	NNP
cord-015021-pol2qm74	1847	5	Kiel	Kiel	NNP
cord-015021-pol2qm74	1847	6	,	,	,
cord-015021-pol2qm74	1847	7	Schwanenweg	Schwanenweg	NNP
cord-015021-pol2qm74	1847	8	21	21	CD
cord-015021-pol2qm74	1847	9	,	,	,
cord-015021-pol2qm74	1847	10	24105	24105	CD
cord-015021-pol2qm74	1847	11	Kiel	Kiel	NNP
cord-015021-pol2qm74	1847	12	,	,	,
cord-015021-pol2qm74	1847	13	Germany	Germany	NNP
cord-015021-pol2qm74	1847	14	.	.	.
cord-015021-pol2qm74	1848	1	Objectives	objective	NNS
cord-015021-pol2qm74	1848	2	of	of	IN
cord-015021-pol2qm74	1848	3	the	the	DT
cord-015021-pol2qm74	1848	4	study	study	NN
cord-015021-pol2qm74	1848	5	:	:	:
cord-015021-pol2qm74	1848	6	Major	major	JJ
cord-015021-pol2qm74	1848	7	emphasis	emphasis	NN
cord-015021-pol2qm74	1848	8	has	have	VBZ
cord-015021-pol2qm74	1848	9	been	be	VBN
cord-015021-pol2qm74	1848	10	given	give	VBN
cord-015021-pol2qm74	1848	11	to	to	IN
cord-015021-pol2qm74	1848	12	the	the	DT
cord-015021-pol2qm74	1848	13	analysis	analysis	NN
cord-015021-pol2qm74	1848	14	of	of	IN
cord-015021-pol2qm74	1848	15	interactions	interaction	NNS
cord-015021-pol2qm74	1848	16	of	of	IN
cord-015021-pol2qm74	1848	17	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	1848	18	with	with	IN
cord-015021-pol2qm74	1848	19	microorganisms	microorganism	NNS
cord-015021-pol2qm74	1848	20	.	.	.
cord-015021-pol2qm74	1849	1	Effects	effect	NNS
cord-015021-pol2qm74	1849	2	of	of	IN
cord-015021-pol2qm74	1849	3	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	1849	4	on	on	IN
cord-015021-pol2qm74	1849	5	cells	cell	NNS
cord-015021-pol2qm74	1849	6	of	of	IN
cord-015021-pol2qm74	1849	7	primary	primary	JJ
cord-015021-pol2qm74	1849	8	host	host	NN
cord-015021-pol2qm74	1849	9	defense	defense	NN
cord-015021-pol2qm74	1849	10	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1849	11	,	,	,
cord-015021-pol2qm74	1849	12	such	such	JJ
cord-015021-pol2qm74	1849	13	as	as	IN
cord-015021-pol2qm74	1849	14	the	the	DT
cord-015021-pol2qm74	1849	15	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1849	16	,	,	,
cord-015021-pol2qm74	1849	17	are	be	VBP
cord-015021-pol2qm74	1849	18	less	less	RBR
cord-015021-pol2qm74	1849	19	well	well	RB
cord-015021-pol2qm74	1849	20	known	known	JJ
cord-015021-pol2qm74	1849	21	.	.	.
cord-015021-pol2qm74	1850	1	Therefore	therefore	RB
cord-015021-pol2qm74	1850	2	,	,	,
cord-015021-pol2qm74	1850	3	attention	attention	NN
cord-015021-pol2qm74	1850	4	has	have	VBZ
cord-015021-pol2qm74	1850	5	been	be	VBN
cord-015021-pol2qm74	1850	6	focused	focus	VBN
cord-015021-pol2qm74	1850	7	on	on	IN
cord-015021-pol2qm74	1850	8	clindamycin	clindamycin	NN
cord-015021-pol2qm74	1850	9	,	,	,
cord-015021-pol2qm74	1850	10	a	a	DT
cord-015021-pol2qm74	1850	11	member	member	NN
cord-015021-pol2qm74	1850	12	of	of	IN
cord-015021-pol2qm74	1850	13	the	the	DT
cord-015021-pol2qm74	1850	14	lincoseamide	lincoseamide	NNP
cord-015021-pol2qm74	1850	15	family	family	NN
cord-015021-pol2qm74	1850	16	.	.	.
cord-015021-pol2qm74	1851	1	Materials	material	NNS
cord-015021-pol2qm74	1851	2	and	and	CC
cord-015021-pol2qm74	1851	3	methods	method	NNS
cord-015021-pol2qm74	1851	4	:	:	:
cord-015021-pol2qm74	1852	1	The	the	DT
cord-015021-pol2qm74	1852	2	effect	effect	NN
cord-015021-pol2qm74	1852	3	of	of	IN
cord-015021-pol2qm74	1852	4	clindamycin	clindamycin	NN
cord-015021-pol2qm74	1852	5	(	(	-LRB-
cord-015021-pol2qm74	1852	6	i	i	PRP
cord-015021-pol2qm74	1852	7	-i00	-i00	VBD
cord-015021-pol2qm74	1853	1	~g	~g	NNP
cord-015021-pol2qm74	1854	1	/ml	/ml	NFP
cord-015021-pol2qm74	1854	2	)	)	-RRB-
cord-015021-pol2qm74	1854	3	on	on	IN
cord-015021-pol2qm74	1854	4	8	8	CD
cord-015021-pol2qm74	1854	5	granulocyte	granulocyte	NN
cord-015021-pol2qm74	1854	6	functions	function	NNS
cord-015021-pol2qm74	1854	7	(	(	-LRB-
cord-015021-pol2qm74	1854	8	healthy	healthy	JJ
cord-015021-pol2qm74	1854	9	volunteers	volunteer	NNS
cord-015021-pol2qm74	1854	10	)	)	-RRB-
cord-015021-pol2qm74	1854	11	such	such	JJ
cord-015021-pol2qm74	1854	12	as	as	IN
cord-015021-pol2qm74	1854	13	random	random	JJ
cord-015021-pol2qm74	1854	14	migration	migration	NN
cord-015021-pol2qm74	1854	15	,	,	,
cord-015021-pol2qm74	1854	16	chemotaxis	chemotaxis	NN
cord-015021-pol2qm74	1854	17	(	(	-LRB-
cord-015021-pol2qm74	1854	18	agarose	agarose	JJ
cord-015021-pol2qm74	1854	19	method	method	NN
cord-015021-pol2qm74	1854	20	)	)	-RRB-
cord-015021-pol2qm74	1854	21	,	,	,
cord-015021-pol2qm74	1854	22	ingestion	ingestion	NN
cord-015021-pol2qm74	1854	23	(	(	-LRB-
cord-015021-pol2qm74	1854	24	radiometric	radiometric	JJ
cord-015021-pol2qm74	1854	25	assay	assay	NN
cord-015021-pol2qm74	1854	26	)	)	-RRB-
cord-015021-pol2qm74	1854	27	,	,	,
cord-015021-pol2qm74	1854	28	superoxide	superoxide	NN
cord-015021-pol2qm74	1854	29	(	(	-LRB-
cord-015021-pol2qm74	1854	30	cytochrom	cytochrom	NNP
cord-015021-pol2qm74	1854	31	c	c	NNP
cord-015021-pol2qm74	1854	32	reduction	reduction	NN
cord-015021-pol2qm74	1854	33	)	)	-RRB-
cord-015021-pol2qm74	1854	34	and	and	CC
cord-015021-pol2qm74	1854	35	hydrogen	hydrogen	NN
cord-015021-pol2qm74	1854	36	peroxide	peroxide	NN
cord-015021-pol2qm74	1854	37	production	production	NN
cord-015021-pol2qm74	1854	38	(	(	-LRB-
cord-015021-pol2qm74	1854	39	phenol	phenol	NN
cord-015021-pol2qm74	1854	40	red	red	JJ
cord-015021-pol2qm74	1854	41	oxidation	oxidation	NN
cord-015021-pol2qm74	1854	42	)	)	-RRB-
cord-015021-pol2qm74	1854	43	,	,	,
cord-015021-pol2qm74	1854	44	lucigenin	lucigenin	NNP
cord-015021-pol2qm74	1854	45	-	-	HYPH
cord-015021-pol2qm74	1854	46	and	and	CC
cord-015021-pol2qm74	1854	47	luminol	luminol	NN
cord-015021-pol2qm74	1854	48	-	-	HYPH
cord-015021-pol2qm74	1854	49	amplified	amplify	VBN
cord-015021-pol2qm74	1854	50	chemiluminescence	chemiluminescence	NN
cord-015021-pol2qm74	1854	51	(	(	-LRB-
cord-015021-pol2qm74	1854	52	luminometry	luminometry	NNP
cord-015021-pol2qm74	1854	53	)	)	-RRB-
cord-015021-pol2qm74	1854	54	and	and	CC
cord-015021-pol2qm74	1854	55	degranulation	degranulation	NN
cord-015021-pol2qm74	1854	56	(	(	-LRB-
cord-015021-pol2qm74	1854	57	turbidometry	turbidometry	NN
cord-015021-pol2qm74	1854	58	with	with	IN
cord-015021-pol2qm74	1854	59	Micrococcus	Micrococcus	NNP
cord-015021-pol2qm74	1854	60	lysodeicticus	lysodeicticus	NNP
cord-015021-pol2qm74	1854	61	)	)	-RRB-
cord-015021-pol2qm74	1854	62	were	be	VBD
cord-015021-pol2qm74	1854	63	investigated	investigate	VBN
cord-015021-pol2qm74	1854	64	in	in	IN
cord-015021-pol2qm74	1854	65	vitro	vitro	FW
cord-015021-pol2qm74	1854	66	.	.	.
cord-015021-pol2qm74	1855	1	Results	result	NNS
cord-015021-pol2qm74	1855	2	:	:	:
cord-015021-pol2qm74	1856	1	Motility	motility	NN
cord-015021-pol2qm74	1856	2	and	and	CC
cord-015021-pol2qm74	1856	3	degranulation	degranulation	NN
cord-015021-pol2qm74	1856	4	were	be	VBD
cord-015021-pol2qm74	1856	5	inhibited	inhibit	VBN
cord-015021-pol2qm74	1856	6	,	,	,
cord-015021-pol2qm74	1856	7	ingestion	ingestion	NN
cord-015021-pol2qm74	1856	8	of	of	IN
cord-015021-pol2qm74	1856	9	Saccharomyces	Saccharomyces	NNP
cord-015021-pol2qm74	1856	10	cerevisiae	cerevisiae	NNS
cord-015021-pol2qm74	1856	11	,	,	,
cord-015021-pol2qm74	1856	12	zymosan	zymosan	NNP
cord-015021-pol2qm74	1856	13	-	-	HYPH
cord-015021-pol2qm74	1856	14	induced	induce	VBN
cord-015021-pol2qm74	1856	15	lucigenin	lucigenin	NNP
cord-015021-pol2qm74	1856	16	-	-	HYPH
cord-015021-pol2qm74	1856	17	and	and	CC
cord-015021-pol2qm74	1856	18	luminol	luminol	NN
cord-015021-pol2qm74	1856	19	-	-	HYPH
cord-015021-pol2qm74	1856	20	amplified	amplify	VBN
cord-015021-pol2qm74	1856	21	chemiluminescence	chemiluminescence	NN
cord-015021-pol2qm74	1856	22	,	,	,
cord-015021-pol2qm74	1856	23	superoxide	superoxide	NN
cord-015021-pol2qm74	1856	24	and	and	CC
cord-015021-pol2qm74	1856	25	hydrogen	hydrogen	NN
cord-015021-pol2qm74	1856	26	peroxide	peroxide	NN
cord-015021-pol2qm74	1856	27	production	production	NN
cord-015021-pol2qm74	1856	28	were	be	VBD
cord-015021-pol2qm74	1856	29	stimulated	stimulate	VBN
cord-015021-pol2qm74	1856	30	in	in	IN
cord-015021-pol2qm74	1856	31	a	a	DT
cord-015021-pol2qm74	1856	32	dose	dose	JJ
cord-015021-pol2qm74	1856	33	dependent	dependent	JJ
cord-015021-pol2qm74	1856	34	fashion	fashion	NN
cord-015021-pol2qm74	1856	35	.	.	.
cord-015021-pol2qm74	1857	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	1857	2	:	:	:
cord-015021-pol2qm74	1858	1	Clindamycin	Clindamycin	NNP
cord-015021-pol2qm74	1858	2	has	have	VBZ
cord-015021-pol2qm74	1858	3	granulocyte	granulocyte	NN
cord-015021-pol2qm74	1858	4	function	function	NN
cord-015021-pol2qm74	1858	5	modulating	modulate	VBG
cord-015021-pol2qm74	1858	6	properties	property	NNS
cord-015021-pol2qm74	1858	7	.	.	.
cord-015021-pol2qm74	1859	1	Recognition	recognition	NN
cord-015021-pol2qm74	1859	2	of	of	IN
cord-015021-pol2qm74	1859	3	immunomodulating	immunomodulating	JJ
cord-015021-pol2qm74	1859	4	effects	effect	NNS
cord-015021-pol2qm74	1859	5	of	of	IN
cord-015021-pol2qm74	1859	6	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	1859	7	may	may	MD
cord-015021-pol2qm74	1859	8	have	have	VB
cord-015021-pol2qm74	1859	9	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	1859	10	significance	significance	NN
cord-015021-pol2qm74	1859	11	,	,	,
cord-015021-pol2qm74	1859	12	especially	especially	RB
cord-015021-pol2qm74	1859	13	in	in	IN
cord-015021-pol2qm74	1859	14	patients	patient	NNS
cord-015021-pol2qm74	1859	15	with	with	IN
cord-015021-pol2qm74	1859	16	long	long	JJ
cord-015021-pol2qm74	1859	17	-	-	HYPH
cord-015021-pol2qm74	1859	18	term	term	NN
cord-015021-pol2qm74	1859	19	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	1859	20	therapy	therapy	NN
cord-015021-pol2qm74	1859	21	or	or	CC
cord-015021-pol2qm74	1859	22	immune	immune	JJ
cord-015021-pol2qm74	1859	23	deficiencies	deficiency	NNS
cord-015021-pol2qm74	1859	24	.	.	.
cord-015021-pol2qm74	1860	1	The	the	DT
cord-015021-pol2qm74	1860	2	intense	intense	JJ
cord-015021-pol2qm74	1860	3	muscle	muscle	NN
cord-015021-pol2qm74	1860	4	activity	activity	NN
cord-015021-pol2qm74	1860	5	(	(	-LRB-
cord-015021-pol2qm74	1860	6	EA	EA	NNP
cord-015021-pol2qm74	1860	7	)	)	-RRB-
cord-015021-pol2qm74	1860	8	of	of	IN
cord-015021-pol2qm74	1860	9	rats	rat	NNS
cord-015021-pol2qm74	1860	10	resulted	result	VBD
cord-015021-pol2qm74	1860	11	in	in	IN
cord-015021-pol2qm74	1860	12	increase	increase	NN
cord-015021-pol2qm74	1860	13	of	of	IN
cord-015021-pol2qm74	1860	14	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1860	15	influx	influx	NN
cord-015021-pol2qm74	1860	16	in	in	IN
cord-015021-pol2qm74	1860	17	muscles	muscle	NNS
cord-015021-pol2qm74	1860	18	during	during	IN
cord-015021-pol2qm74	1860	19	the	the	DT
cord-015021-pol2qm74	1860	20	recovery	recovery	NN
cord-015021-pol2qm74	1860	21	.	.	.
cord-015021-pol2qm74	1861	1	We	-PRON-	PRP
cord-015021-pol2qm74	1861	2	investigated	investigate	VBD
cord-015021-pol2qm74	1861	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1861	4	proteinases	proteinases	NNP
cord-015021-pol2qm74	1861	5	involvement	involvement	NN
cord-015021-pol2qm74	1861	6	in	in	IN
cord-015021-pol2qm74	1861	7	neutral	neutral	JJ
cord-015021-pol2qm74	1861	8	proteinases	proteinases	JJ
cord-015021-pol2qm74	1861	9	balance	balance	NN
cord-015021-pol2qm74	1861	10	of	of	IN
cord-015021-pol2qm74	1861	11	skeletal	skeletal	JJ
cord-015021-pol2qm74	1861	12	muscles	muscle	NNS
cord-015021-pol2qm74	1861	13	by	by	IN
cord-015021-pol2qm74	1861	14	NA	NA	NNP
cord-015021-pol2qm74	1861	15	.	.	.
cord-015021-pol2qm74	1862	1	The	the	DT
cord-015021-pol2qm74	1862	2	rats	rat	NNS
cord-015021-pol2qm74	1862	3	were	be	VBD
cord-015021-pol2qm74	1862	4	submited	submit	VBN
cord-015021-pol2qm74	1862	5	to	to	TO
cord-015021-pol2qm74	1862	6	swim	swim	VB
cord-015021-pol2qm74	1862	7	with	with	IN
cord-015021-pol2qm74	1862	8	the	the	DT
cord-015021-pol2qm74	1862	9	load	load	NN
cord-015021-pol2qm74	1862	10	(	(	-LRB-
cord-015021-pol2qm74	1862	11	8	8	CD
cord-015021-pol2qm74	1862	12	%	%	NN
cord-015021-pol2qm74	1862	13	of	of	IN
cord-015021-pol2qm74	1862	14	body	body	NN
cord-015021-pol2qm74	1862	15	mass	mass	NN
cord-015021-pol2qm74	1862	16	)	)	-RRB-
cord-015021-pol2qm74	1862	17	till	till	IN
cord-015021-pol2qm74	1862	18	exhaustion	exhaustion	NN
cord-015021-pol2qm74	1862	19	.	.	.
cord-015021-pol2qm74	1863	1	Immediately	immediately	RB
cord-015021-pol2qm74	1863	2	after	after	IN
cord-015021-pol2qm74	1863	3	NA	NA	NNP
cord-015021-pol2qm74	1863	4	the	the	DT
cord-015021-pol2qm74	1863	5	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1863	6	antiserum	antiserum	NN
cord-015021-pol2qm74	1863	7	was	be	VBD
cord-015021-pol2qm74	1863	8	injected	inject	VBN
cord-015021-pol2qm74	1863	9	i.p	i.p	NNP
cord-015021-pol2qm74	1863	10	.	.	NNP
cord-015021-pol2qm74	1863	11	to	to	IN
cord-015021-pol2qm74	1863	12	rats	rat	NNS
cord-015021-pol2qm74	1863	13	of	of	IN
cord-015021-pol2qm74	1863	14	experimental	experimental	JJ
cord-015021-pol2qm74	1863	15	group	group	NN
cord-015021-pol2qm74	1863	16	.	.	.
cord-015021-pol2qm74	1864	1	Saline	Saline	NNP
cord-015021-pol2qm74	1864	2	was	be	VBD
cord-015021-pol2qm74	1864	3	injected	inject	VBN
cord-015021-pol2qm74	1864	4	to	to	TO
cord-015021-pol2qm74	1864	5	control	control	VB
cord-015021-pol2qm74	1864	6	animals	animal	NNS
cord-015021-pol2qm74	1864	7	°	°	NNS
cord-015021-pol2qm74	1864	8	Injections	injection	NNS
cord-015021-pol2qm74	1864	9	were	be	VBD
cord-015021-pol2qm74	1864	10	repeated	repeat	VBN
cord-015021-pol2qm74	1864	11	in	in	IN
cord-015021-pol2qm74	1864	12	12	12	CD
cord-015021-pol2qm74	1864	13	h	h	NN
cord-015021-pol2qm74	1864	14	of	of	IN
cord-015021-pol2qm74	1864	15	the	the	DT
cord-015021-pol2qm74	1864	16	recovery	recovery	NN
cord-015021-pol2qm74	1864	17	and	and	CC
cord-015021-pol2qm74	1864	18	cytosol	cytosol	NN
cord-015021-pol2qm74	1864	19	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	1864	20	activity	activity	NN
cord-015021-pol2qm74	1864	21	(	(	-LRB-
cord-015021-pol2qm74	1864	22	pH	pH	NNP
cord-015021-pol2qm74	1864	23	7.4	7.4	CD
cord-015021-pol2qm74	1864	24	;	;	:
cord-015021-pol2qm74	1864	25	FITC	FITC	NNP
cord-015021-pol2qm74	1864	26	-	-	HYPH
cord-015021-pol2qm74	1864	27	casein	casein	NN
cord-015021-pol2qm74	1864	28	)	)	-RRB-
cord-015021-pol2qm74	1864	29	was	be	VBD
cord-015021-pol2qm74	1864	30	determined	determine	VBN
cord-015021-pol2qm74	1864	31	.	.	.
cord-015021-pol2qm74	1865	1	Isolated	isolated	JJ
cord-015021-pol2qm74	1865	2	soleus	soleus	NN
cord-015021-pol2qm74	1865	3	muscles	muscle	NNS
cord-015021-pol2qm74	1865	4	were	be	VBD
cord-015021-pol2qm74	1865	5	incubated	incubate	VBN
cord-015021-pol2qm74	1865	6	also	also	RB
cord-015021-pol2qm74	1865	7	in	in	IN
cord-015021-pol2qm74	1865	8	vitro	vitro	FW
cord-015021-pol2qm74	1865	9	and	and	CC
cord-015021-pol2qm74	1865	10	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	1865	11	activity	activity	NN
cord-015021-pol2qm74	1865	12	of	of	IN
cord-015021-pol2qm74	1865	13	incubation	incubation	NN
cord-015021-pol2qm74	1865	14	media	medium	NNS
cord-015021-pol2qm74	1865	15	was	be	VBD
cord-015021-pol2qm74	1865	16	measured	measure	VBN
cord-015021-pol2qm74	1865	17	.	.	.
cord-015021-pol2qm74	1866	1	It	-PRON-	PRP
cord-015021-pol2qm74	1866	2	was	be	VBD
cord-015021-pol2qm74	1866	3	found	find	VBN
cord-015021-pol2qm74	1866	4	that	that	IN
cord-015021-pol2qm74	1866	5	there	there	EX
cord-015021-pol2qm74	1866	6	was	be	VBD
cord-015021-pol2qm74	1866	7	2	2	CD
cord-015021-pol2qm74	1866	8	-	-	SYM
cord-015021-pol2qm74	1866	9	3	3	CD
cord-015021-pol2qm74	1866	10	-fold	-fold	NN
cord-015021-pol2qm74	1866	11	proteinases	proteinase	NNS
cord-015021-pol2qm74	1866	12	activity	activity	NN
cord-015021-pol2qm74	1866	13	increase	increase	NN
cord-015021-pol2qm74	1866	14	in	in	IN
cord-015021-pol2qm74	1866	15	cytosols	cytosol	NNS
cord-015021-pol2qm74	1866	16	of	of	IN
cord-015021-pol2qm74	1866	17	all	all	DT
cord-015021-pol2qm74	1866	18	investigated	investigate	VBN
cord-015021-pol2qm74	1866	19	muscles	muscle	NNS
cord-015021-pol2qm74	1866	20	(	(	-LRB-
cord-015021-pol2qm74	1866	21	soleus	soleus	NN
cord-015021-pol2qm74	1866	22	,	,	,
cord-015021-pol2qm74	1866	23	white	white	JJ
cord-015021-pol2qm74	1866	24	and	and	CC
cord-015021-pol2qm74	1866	25	red	red	JJ
cord-015021-pol2qm74	1866	26	portions	portion	NNS
cord-015021-pol2qm74	1866	27	of	of	IN
cord-015021-pol2qm74	1866	28	quadriceps	quadricep	NNS
cord-015021-pol2qm74	1866	29	)	)	-RRB-
cord-015021-pol2qm74	1866	30	of	of	IN
cord-015021-pol2qm74	1866	31	control	control	NN
cord-015021-pol2qm74	1866	32	animals	animal	NNS
cord-015021-pol2qm74	1866	33	by	by	IN
cord-015021-pol2qm74	1866	34	6	6	CD
cord-015021-pol2qm74	1866	35	h	h	NN
cord-015021-pol2qm74	1866	36	of	of	IN
cord-015021-pol2qm74	1866	37	the	the	DT
cord-015021-pol2qm74	1866	38	recovery	recovery	NN
cord-015021-pol2qm74	1866	39	(	(	-LRB-
cord-015021-pol2qm74	1866	40	the	the	DT
cord-015021-pol2qm74	1866	41	comparison	comparison	NN
cord-015021-pol2qm74	1866	42	was	be	VBD
cord-015021-pol2qm74	1866	43	done	do	VBN
cord-015021-pol2qm74	1866	44	with	with	IN
cord-015021-pol2qm74	1866	45	the	the	DT
cord-015021-pol2qm74	1866	46	sedentary	sedentary	JJ
cord-015021-pol2qm74	1866	47	rats	rat	NNS
cord-015021-pol2qm74	1866	48	)	)	-RRB-
cord-015021-pol2qm74	1866	49	.	.	.
cord-015021-pol2qm74	1867	1	In	in	IN
cord-015021-pol2qm74	1867	2	12	12	CD
cord-015021-pol2qm74	1867	3	h	h	NN
cord-015021-pol2qm74	1867	4	cytosol	cytosol	NN
cord-015021-pol2qm74	1867	5	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	1867	6	activity	activity	NN
cord-015021-pol2qm74	1867	7	decreased	decrease	VBD
cord-015021-pol2qm74	1867	8	and	and	CC
cord-015021-pol2qm74	1867	9	then	then	RB
cord-015021-pol2qm74	1867	10	increased	increase	VBD
cord-015021-pol2qm74	1867	11	again	again	RB
cord-015021-pol2qm74	1867	12	by	by	IN
cord-015021-pol2qm74	1867	13	24	24	CD
cord-015021-pol2qm74	1867	14	h	h	NN
cord-015021-pol2qm74	1867	15	of	of	IN
cord-015021-pol2qm74	1867	16	the	the	DT
cord-015021-pol2qm74	1867	17	fast	fast	NN
cord-015021-pol2qm74	1867	18	.	.	.
cord-015021-pol2qm74	1868	1	Antiserum	antiserum	NN
cord-015021-pol2qm74	1868	2	injections	injection	NNS
cord-015021-pol2qm74	1868	3	resulted	result	VBD
cord-015021-pol2qm74	1868	4	in	in	IN
cord-015021-pol2qm74	1868	5	relible	relible	JJ
cord-015021-pol2qm74	1868	6	decrease	decrease	NN
cord-015021-pol2qm74	1868	7	of	of	IN
cord-015021-pol2qm74	1868	8	the	the	DT
cord-015021-pol2qm74	1868	9	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	1868	10	activities	activity	NNS
cord-015021-pol2qm74	1868	11	at	at	IN
cord-015021-pol2qm74	1868	12	every	every	DT
cord-015021-pol2qm74	1868	13	investigated	investigate	VBN
cord-015021-pol2qm74	1868	14	time	time	NN
cord-015021-pol2qm74	1868	15	.	.	.
cord-015021-pol2qm74	1869	1	When	when	WRB
cord-015021-pol2qm74	1869	2	incubating	incubate	VBG
cord-015021-pol2qm74	1869	3	m.	m.	NN
cord-015021-pol2qm74	1869	4	soleus	soleus	NN
cord-015021-pol2qm74	1869	5	in	in	IN
cord-015021-pol2qm74	1869	6	vitro	vitro	FW
cord-015021-pol2qm74	1869	7	the	the	DT
cord-015021-pol2qm74	1869	8	activities	activity	NNS
cord-015021-pol2qm74	1869	9	of	of	IN
cord-015021-pol2qm74	1869	10	proteinases	proteinases	NNP
cord-015021-pol2qm74	1869	11	in	in	IN
cord-015021-pol2qm74	1869	12	incubation	incubation	NN
cord-015021-pol2qm74	1869	13	media	medium	NNS
cord-015021-pol2qm74	1869	14	turned	turn	VBD
cord-015021-pol2qm74	1869	15	out	out	RP
cord-015021-pol2qm74	1869	16	reliably	reliably	RB
cord-015021-pol2qm74	1869	17	less	less	RBR
cord-015021-pol2qm74	1869	18	if	if	IN
cord-015021-pol2qm74	1869	19	soleus	soleus	NN
cord-015021-pol2qm74	1869	20	muscles	muscle	NNS
cord-015021-pol2qm74	1869	21	were	be	VBD
cord-015021-pol2qm74	1869	22	isolated	isolate	VBN
cord-015021-pol2qm74	1869	23	from	from	IN
cord-015021-pol2qm74	1869	24	the	the	DT
cord-015021-pol2qm74	1869	25	animals	animal	NNS
cord-015021-pol2qm74	1869	26	to	to	TO
cord-015021-pol2qm74	1869	27	which	which	WDT
cord-015021-pol2qm74	1869	28	antiserum	antiserum	NN
cord-015021-pol2qm74	1869	29	was	be	VBD
cord-015021-pol2qm74	1869	30	injected	inject	VBN
cord-015021-pol2qm74	1869	31	.	.	.
cord-015021-pol2qm74	1870	1	The	the	DT
cord-015021-pol2qm74	1870	2	conclusion	conclusion	NN
cord-015021-pol2qm74	1870	3	is	be	VBZ
cord-015021-pol2qm74	1870	4	that	that	IN
cord-015021-pol2qm74	1870	5	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1870	6	proteinases	proteinase	NNS
cord-015021-pol2qm74	1870	7	can	can	MD
cord-015021-pol2qm74	1870	8	be	be	VB
cord-015021-pol2qm74	1870	9	involved	involve	VBN
cord-015021-pol2qm74	1870	10	in	in	IN
cord-015021-pol2qm74	1870	11	the	the	DT
cord-015021-pol2qm74	1870	12	balance	balance	NN
cord-015021-pol2qm74	1870	13	of	of	IN
cord-015021-pol2qm74	1870	14	rat	rat	NN
cord-015021-pol2qm74	1870	15	skeletal	skeletal	JJ
cord-015021-pol2qm74	1870	16	muscle	muscle	NN
cord-015021-pol2qm74	1870	17	neutral	neutral	JJ
cord-015021-pol2qm74	1870	18	proteinases	proteinase	NNS
cord-015021-pol2qm74	1870	19	after	after	IN
cord-015021-pol2qm74	1870	20	~A.	~a.	JJ
cord-015021-pol2qm74	1871	1	A	a	DT
cord-015021-pol2qm74	1871	2	lot	lot	NN
cord-015021-pol2qm74	1871	3	and	and	CC
cord-015021-pol2qm74	1871	4	new	new	JJ
cord-015021-pol2qm74	1871	5	clinical	clinical	JJ
cord-015021-pol2qm74	1871	6	problems	problem	NNS
cord-015021-pol2qm74	1871	7	complicating	complicate	VBG
cord-015021-pol2qm74	1871	8	the	the	DT
cord-015021-pol2qm74	1871	9	outcome	outcome	NN
cord-015021-pol2qm74	1871	10	of	of	IN
cord-015021-pol2qm74	1871	11	polytrauma	polytrauma	NNP
cord-015021-pol2qm74	1871	12	,	,	,
cord-015021-pol2qm74	1871	13	burn	burn	VB
cord-015021-pol2qm74	1871	14	and	and	CC
cord-015021-pol2qm74	1871	15	septic	septic	JJ
cord-015021-pol2qm74	1871	16	patients	patient	NNS
cord-015021-pol2qm74	1871	17	in	in	IN
cord-015021-pol2qm74	1871	18	Surgical	Surgical	NNP
cord-015021-pol2qm74	1871	19	Intensive	Intensive	NNP
cord-015021-pol2qm74	1871	20	Care	Care	NNP
cord-015021-pol2qm74	1871	21	Units	Units	NNPS
cord-015021-pol2qm74	1871	22	,	,	,
cord-015021-pol2qm74	1871	23	have	have	VBP
cord-015021-pol2qm74	1871	24	arisen	arise	VBN
cord-015021-pol2qm74	1871	25	as	as	IN
cord-015021-pol2qm74	1871	26	the	the	DT
cord-015021-pol2qm74	1871	27	care	care	NN
cord-015021-pol2qm74	1871	28	improvement	improvement	NN
cord-015021-pol2qm74	1871	29	prolonged	prolong	VBD
cord-015021-pol2qm74	1871	30	the	the	DT
cord-015021-pol2qm74	1871	31	patient	patient	NN
cord-015021-pol2qm74	1871	32	's	's	POS
cord-015021-pol2qm74	1871	33	survival	survival	NN
cord-015021-pol2qm74	1871	34	:	:	:
cord-015021-pol2qm74	1871	35	a	a	DT
cord-015021-pol2qm74	1871	36	progressive	progressive	JJ
cord-015021-pol2qm74	1871	37	degradation	degradation	NN
cord-015021-pol2qm74	1871	38	of	of	IN
cord-015021-pol2qm74	1871	39	organ	organ	NN
cord-015021-pol2qm74	1871	40	and	and	CC
cord-015021-pol2qm74	1871	41	system	system	NN
cord-015021-pol2qm74	1871	42	functions	function	NNS
cord-015021-pol2qm74	1871	43	often	often	RB
cord-015021-pol2qm74	1871	44	develops	develop	VBZ
cord-015021-pol2qm74	1871	45	,	,	,
cord-015021-pol2qm74	1871	46	usually	usually	RB
cord-015021-pol2qm74	1871	47	making	make	VBG
cord-015021-pol2qm74	1871	48	its	-PRON-	PRP$
cord-015021-pol2qm74	1871	49	first	first	JJ
cord-015021-pol2qm74	1871	50	clinical	clinical	JJ
cord-015021-pol2qm74	1871	51	appearance	appearance	NN
cord-015021-pol2qm74	1871	52	by	by	IN
cord-015021-pol2qm74	1871	53	ARDS	ARDS	NNP
cord-015021-pol2qm74	1871	54	,	,	,
cord-015021-pol2qm74	1871	55	followed	follow	VBN
cord-015021-pol2qm74	1871	56	by	by	IN
cord-015021-pol2qm74	1871	57	the	the	DT
cord-015021-pol2qm74	1871	58	other	other	JJ
cord-015021-pol2qm74	1871	59	organ	organ	NN
cord-015021-pol2qm74	1871	60	failure	failure	NN
cord-015021-pol2qm74	1871	61	(	(	-LRB-
cord-015021-pol2qm74	1871	62	MOF	MOF	NNP
cord-015021-pol2qm74	1871	63	)	)	-RRB-
cord-015021-pol2qm74	1871	64	and	and	CC
cord-015021-pol2qm74	1871	65	sepsis	sepsis	NN
cord-015021-pol2qm74	1871	66	symptoms	symptom	NNS
cord-015021-pol2qm74	1871	67	.	.	.
cord-015021-pol2qm74	1872	1	The	the	DT
cord-015021-pol2qm74	1872	2	clinical	clinical	JJ
cord-015021-pol2qm74	1872	3	picture	picture	NN
cord-015021-pol2qm74	1872	4	is	be	VBZ
cord-015021-pol2qm74	1872	5	polymorphic	polymorphic	JJ
cord-015021-pol2qm74	1872	6	,	,	,
cord-015021-pol2qm74	1872	7	the	the	DT
cord-015021-pol2qm74	1872	8	end	end	NN
cord-015021-pol2qm74	1872	9	result	result	NN
cord-015021-pol2qm74	1872	10	of	of	IN
cord-015021-pol2qm74	1872	11	a	a	DT
cord-015021-pol2qm74	1872	12	complex	complex	JJ
cord-015021-pol2qm74	1872	13	systemic	systemic	JJ
cord-015021-pol2qm74	1872	14	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	1872	15	reaction	reaction	NN
cord-015021-pol2qm74	1872	16	trigg	trigg	NNP
cord-015021-pol2qm74	1872	17	~	~	NFP
cord-015021-pol2qm74	1872	18	ed	ed	NNP
cord-015021-pol2qm74	1872	19	off	off	RP
cord-015021-pol2qm74	1872	20	by	by	IN
cord-015021-pol2qm74	1872	21	trauma	trauma	NN
cord-015021-pol2qm74	1872	22	consequences	consequence	NNS
cord-015021-pol2qm74	1872	23	(	(	-LRB-
cord-015021-pol2qm74	1872	24	tissues	tissue	NNS
cord-015021-pol2qm74	1872	25	disruption	disruption	NN
cord-015021-pol2qm74	1872	26	,	,	,
cord-015021-pol2qm74	1872	27	hypo	hypo	NNP
cord-015021-pol2qm74	1872	28	~	~	NFP
cord-015021-pol2qm74	1872	29	xygenatiun	xygenatiun	NNP
cord-015021-pol2qm74	1872	30	and	and	CC
cord-015021-pol2qm74	1872	31	necrosis	necrosis	NN
cord-015021-pol2qm74	1872	32	)	)	-RRB-
cord-015021-pol2qm74	1872	33	.	.	.
cord-015021-pol2qm74	1873	1	Nowadays	nowadays	RB
cord-015021-pol2qm74	1873	2	there	there	EX
cord-015021-pol2qm74	1873	3	is	be	VBZ
cord-015021-pol2qm74	1873	4	not	not	RB
cord-015021-pol2qm74	1873	5	a	a	DT
cord-015021-pol2qm74	1873	6	preventi~	preventi~	JJ
cord-015021-pol2qm74	1873	7	or	or	CC
cord-015021-pol2qm74	1873	8	specific	specific	JJ
cord-015021-pol2qm74	1873	9	therapy	therapy	NN
cord-015021-pol2qm74	1873	10	to	to	TO
cord-015021-pol2qm74	1873	11	lower	lower	VB
cord-015021-pol2qm74	1873	12	the	the	DT
cord-015021-pol2qm74	1873	13	mortality	mortality	NN
cord-015021-pol2qm74	1873	14	rate	rate	NN
cord-015021-pol2qm74	1873	15	(	(	-LRB-
cord-015021-pol2qm74	1873	16	70	70	CD
cord-015021-pol2qm74	1873	17	-	-	SYM
cord-015021-pol2qm74	1873	18	80	80	CD
cord-015021-pol2qm74	1873	19	%	%	NN
cord-015021-pol2qm74	1873	20	)	)	-RRB-
cord-015021-pol2qm74	1874	1	and-'mdy	and-'mdy	NNP
cord-015021-pol2qm74	1874	2	-	-	:
cord-015021-pol2qm74	1874	3	a~	a~	''
cord-015021-pol2qm74	1875	1	early	early	RB
cord-015021-pol2qm74	1875	2	,	,	,
cord-015021-pol2qm74	1875	3	aggressive	aggressive	JJ
cord-015021-pol2qm74	1875	4	surgical	surgical	JJ
cord-015021-pol2qm74	1875	5	approach	approach	NN
cord-015021-pol2qm74	1875	6	.-evacuating	.-evacuating	.
cord-015021-pol2qm74	1876	1	haematomas	haematomas	NNP
cord-015021-pol2qm74	1876	2	,	,	,
cord-015021-pol2qm74	1876	3	stopping	stop	VBG
cord-015021-pol2qm74	1876	4	bleeding	bleed	VBG
cord-015021-pol2qm74	1876	5	,	,	,
cord-015021-pol2qm74	1876	6	toileting	toilete	VBG
cord-015021-pol2qm74	1876	7	all	all	DT
cord-015021-pol2qm74	1876	8	septic	septic	JJ
cord-015021-pol2qm74	1876	9	,	,	,
cord-015021-pol2qm74	1876	10	necrotic	necrotic	JJ
cord-015021-pol2qm74	1876	11	foci	foci	NN
cord-015021-pol2qm74	1876	12	and	and	CC
cord-015021-pol2qm74	1876	13	restoring	restore	VBG
cord-015021-pol2qm74	1876	14	anatomic	anatomic	JJ
cord-015021-pol2qm74	1876	15	continuity-	continuity-	NN
cord-015021-pol2qm74	1876	16	,	,	,
cord-015021-pol2qm74	1876	17	seems	seem	VBZ
cord-015021-pol2qm74	1876	18	to	to	TO
cord-015021-pol2qm74	1876	19	be	be	VB
cord-015021-pol2qm74	1876	20	of	of	IN
cord-015021-pol2qm74	1876	21	some	some	DT
cord-015021-pol2qm74	1876	22	help	help	NN
cord-015021-pol2qm74	1876	23	This	this	DT
cord-015021-pol2qm74	1876	24	complex	complex	JJ
cord-015021-pol2qm74	1876	25	clinical	clinical	JJ
cord-015021-pol2qm74	1876	26	entity	entity	NN
cord-015021-pol2qm74	1876	27	has	have	VBZ
cord-015021-pol2qm74	1876	28	not	not	RB
cord-015021-pol2qm74	1876	29	an	an	DT
cord-015021-pol2qm74	1876	30	univocal	univocal	JJ
cord-015021-pol2qm74	1876	31	denomination	denomination	NN
cord-015021-pol2qm74	1876	32	yet	yet	RB
cord-015021-pol2qm74	1876	33	.	.	.
cord-015021-pol2qm74	1877	1	The	the	DT
cord-015021-pol2qm74	1877	2	proper	proper	JJ
cord-015021-pol2qm74	1877	3	labelling	labelling	NN
cord-015021-pol2qm74	1877	4	of	of	IN
cord-015021-pol2qm74	1877	5	an	an	DT
cord-015021-pol2qm74	1877	6	illness	illness	NN
cord-015021-pol2qm74	1877	7	should	should	MD
cord-015021-pol2qm74	1877	8	come	come	VB
cord-015021-pol2qm74	1877	9	from	from	IN
cord-015021-pol2qm74	1877	10	the	the	DT
cord-015021-pol2qm74	1877	11	full	full	JJ
cord-015021-pol2qm74	1877	12	understanding	understanding	NN
cord-015021-pol2qm74	1877	13	of	of	IN
cord-015021-pol2qm74	1877	14	its	-PRON-	PRP$
cord-015021-pol2qm74	1877	15	pathopysiology	pathopysiology	NN
cord-015021-pol2qm74	1877	16	and	and	CC
cord-015021-pol2qm74	1877	17	suggest	suggest	VBP
cord-015021-pol2qm74	1877	18	the	the	DT
cord-015021-pol2qm74	1877	19	proper	proper	JJ
cord-015021-pol2qm74	1877	20	treatment	treatment	NN
cord-015021-pol2qm74	1877	21	choice	choice	NN
cord-015021-pol2qm74	1877	22	.	.	.
cord-015021-pol2qm74	1878	1	Clinical	clinical	JJ
cord-015021-pol2qm74	1878	2	and	and	CC
cord-015021-pol2qm74	1878	3	experimental	experimental	JJ
cord-015021-pol2qm74	1878	4	studies	study	NNS
cord-015021-pol2qm74	1878	5	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	1878	6	that	that	IN
cord-015021-pol2qm74	1878	7	pathophysiologic	pathophysiologic	NN
cord-015021-pol2qm74	1878	8	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1878	9	involved	involve	VBN
cord-015021-pol2qm74	1878	10	in	in	IN
cord-015021-pol2qm74	1878	11	the	the	DT
cord-015021-pol2qm74	1878	12	past	past	JJ
cord-015021-pol2qm74	1878	13	-	-	HYPH
cord-015021-pol2qm74	1878	14	traumatic	traumatic	JJ
cord-015021-pol2qm74	1878	15	illness	illness	NN
cord-015021-pol2qm74	1878	16	,	,	,
cord-015021-pol2qm74	1878	17	share	share	VB
cord-015021-pol2qm74	1878	18	the	the	DT
cord-015021-pol2qm74	1878	19	same	same	JJ
cord-015021-pol2qm74	1878	20	anatomo	anatomo	NN
cord-015021-pol2qm74	1878	21	-	-	HYPH
cord-015021-pol2qm74	1878	22	pathological	pathological	JJ
cord-015021-pol2qm74	1878	23	elemem	elemem	NNS
cord-015021-pol2qm74	1878	24	:	:	:
cord-015021-pol2qm74	1878	25	the	the	DT
cord-015021-pol2qm74	1878	26	interstitial	interstitial	JJ
cord-015021-pol2qm74	1878	27	edema	edema	NN
cord-015021-pol2qm74	1878	28	,	,	,
cord-015021-pol2qm74	1878	29	due	due	IN
cord-015021-pol2qm74	1878	30	to	to	IN
cord-015021-pol2qm74	1878	31	a	a	DT
cord-015021-pol2qm74	1878	32	generalised	generalised	JJ
cord-015021-pol2qm74	1878	33	endothelial	endothelial	JJ
cord-015021-pol2qm74	1878	34	micro	micro	JJ
cord-015021-pol2qm74	1878	35	circulatory	circulatory	JJ
cord-015021-pol2qm74	1878	36	injury	injury	NN
cord-015021-pol2qm74	1878	37	.	.	.
cord-015021-pol2qm74	1879	1	This	this	DT
cord-015021-pol2qm74	1879	2	alteration	alteration	NN
cord-015021-pol2qm74	1879	3	,	,	,
cord-015021-pol2qm74	1879	4	as	as	IN
cord-015021-pol2qm74	1879	5	constantly	constantly	RB
cord-015021-pol2qm74	1879	6	seen	see	VBN
cord-015021-pol2qm74	1879	7	in	in	IN
cord-015021-pol2qm74	1879	8	polytrauma	polytrauma	NN
cord-015021-pol2qm74	1879	9	patients	patient	NNS
cord-015021-pol2qm74	1879	10	,	,	,
cord-015021-pol2qm74	1879	11	develops	develop	VBZ
cord-015021-pol2qm74	1879	12	in	in	IN
cord-015021-pol2qm74	1879	13	a	a	DT
cord-015021-pol2qm74	1879	14	few	few	JJ
cord-015021-pol2qm74	1879	15	hours	hour	NNS
cord-015021-pol2qm74	1879	16	after	after	IN
cord-015021-pol2qm74	1879	17	trauma	trauma	NN
cord-015021-pol2qm74	1879	18	as	as	IN
cord-015021-pol2qm74	1879	19	a	a	DT
cord-015021-pol2qm74	1879	20	consequence	consequence	NN
cord-015021-pol2qm74	1879	21	of	of	IN
cord-015021-pol2qm74	1879	22	the	the	DT
cord-015021-pol2qm74	1879	23	deregulation	deregulation	NN
cord-015021-pol2qm74	1879	24	of	of	IN
cord-015021-pol2qm74	1879	25	the	the	DT
cord-015021-pol2qm74	1879	26	homoeostatic	homoeostatic	JJ
cord-015021-pol2qm74	1879	27	and	and	CC
cord-015021-pol2qm74	1879	28	immune	immune	JJ
cord-015021-pol2qm74	1879	29	mechanisms	mechanism	NNS
cord-015021-pol2qm74	1879	30	.	.	.
cord-015021-pol2qm74	1880	1	In	in	IN
cord-015021-pol2qm74	1880	2	fact	fact	NN
cord-015021-pol2qm74	1880	3	the	the	DT
cord-015021-pol2qm74	1880	4	overproduced	overproduced	JJ
cord-015021-pol2qm74	1880	5	oxygen	oxygen	NN
cord-015021-pol2qm74	1880	6	free	free	JJ
cord-015021-pol2qm74	1880	7	radicals	radical	NNS
cord-015021-pol2qm74	1880	8	and	and	CC
cord-015021-pol2qm74	1880	9	r	r	NNP
cord-015021-pol2qm74	1880	10	~	~	NFP
cord-015021-pol2qm74	1880	11	ombinam	ombinam	NNP
cord-015021-pol2qm74	1880	12	cytokines	cytokine	NNS
cord-015021-pol2qm74	1880	13	(	(	-LRB-
cord-015021-pol2qm74	1880	14	IL1,TNF	IL1,TNF	NNP
cord-015021-pol2qm74	1880	15	)	)	-RRB-
cord-015021-pol2qm74	1880	16	,	,	,
cord-015021-pol2qm74	1880	17	together	together	RB
cord-015021-pol2qm74	1880	18	with	with	IN
cord-015021-pol2qm74	1880	19	the	the	DT
cord-015021-pol2qm74	1880	20	complement	complement	JJ
cord-015021-pol2qm74	1880	21	degradation	degradation	NN
cord-015021-pol2qm74	1880	22	fragments	fragment	NNS
cord-015021-pol2qm74	1880	23	,	,	,
cord-015021-pol2qm74	1880	24	the	the	DT
cord-015021-pol2qm74	1880	25	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	1880	26	enzymes	enzyme	NNS
cord-015021-pol2qm74	1880	27	and	and	CC
cord-015021-pol2qm74	1880	28	many	many	JJ
cord-015021-pol2qm74	1880	29	other	other	JJ
cord-015021-pol2qm74	1880	30	mediators	mediator	NNS
cord-015021-pol2qm74	1880	31	are	be	VBP
cord-015021-pol2qm74	1880	32	all	all	DT
cord-015021-pol2qm74	1880	33	strongly	strongly	RB
cord-015021-pol2qm74	1880	34	h	h	NN
cord-015021-pol2qm74	1881	1	~l	~l	NNP
cord-015021-pol2qm74	1881	2	~	~	NFP
cord-015021-pol2qm74	1881	3	,	,	,
cord-015021-pol2qm74	1881	4	_	_	NNP
cord-015021-pol2qm74	1881	5	he	-PRON-	PRP
cord-015021-pol2qm74	1881	6	e,,j	e,,j	NN
cord-015021-pol2qm74	1881	7	,	,	,
cord-015021-pol2qm74	1881	8	yheha	yheha	NNP
cord-015021-pol2qm74	1881	9	!	!	.
cord-015021-pol2qm74	1882	1	ceils	ceils	NNP
cord-015021-pol2qm74	1882	2	.	.	.
cord-015021-pol2qm74	1883	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	1883	2	~	~	CD
cord-015021-pol2qm74	1883	3	osect	osect	NN
cord-015021-pol2qm74	1883	4	,	,	,
cord-015021-pol2qm74	1883	5	atim~,-bnsed	atim~,-bnse	VBN
cord-015021-pol2qm74	1883	6	on	on	IN
cord-015021-pol2qm74	1883	7	examination	examination	NN
cord-015021-pol2qm74	1883	8	of	of	IN
cord-015021-pol2qm74	1883	9	autopsical	autopsical	JJ
cord-015021-pol2qm74	1883	10	specimens	specimen	NNS
cord-015021-pol2qm74	1883	11	from	from	IN
cord-015021-pol2qm74	1883	12	85	85	CD
cord-015021-pol2qm74	1883	13	polytraanm	polytraanm	NN
cord-015021-pol2qm74	1883	14	patients	patient	NNS
cord-015021-pol2qm74	1883	15	,	,	,
cord-015021-pol2qm74	1883	16	showed	show	VBD
cord-015021-pol2qm74	1883	17	that	that	IN
cord-015021-pol2qm74	1883	18	such	such	JJ
cord-015021-pol2qm74	1883	19	endothelial	endothelial	JJ
cord-015021-pol2qm74	1883	20	damage	damage	NN
cord-015021-pol2qm74	1883	21	,	,	,
cord-015021-pol2qm74	1883	22	supporting	support	VBG
cord-015021-pol2qm74	1883	23	the	the	DT
cord-015021-pol2qm74	1883	24	interstitial	interstitial	JJ
cord-015021-pol2qm74	1883	25	edema	edema	NN
cord-015021-pol2qm74	1883	26	,	,	,
cord-015021-pol2qm74	1883	27	is	be	VBZ
cord-015021-pol2qm74	1883	28	widely	widely	RB
cord-015021-pol2qm74	1883	29	and	and	CC
cord-015021-pol2qm74	1883	30	simultaneensly	simultaneensly	RB
cord-015021-pol2qm74	1883	31	distributed	distribute	VBN
cord-015021-pol2qm74	1883	32	,	,	,
cord-015021-pol2qm74	1883	33	ensues	ensue	VBZ
cord-015021-pol2qm74	1883	34	shortly	shortly	RB
cord-015021-pol2qm74	1883	35	aRer	aRer	NNP
cord-015021-pol2qm74	1883	36	trauma	trauma	NN
cord-015021-pol2qm74	1883	37	and	and	CC
cord-015021-pol2qm74	1883	38	shows	show	VBZ
cord-015021-pol2qm74	1883	39	its	-PRON-	PRP$
cord-015021-pol2qm74	1883	40	effects	effect	NNS
cord-015021-pol2qm74	1883	41	in	in	IN
cord-015021-pol2qm74	1883	42	different	different	JJ
cord-015021-pol2qm74	1883	43	organs	organ	NNS
cord-015021-pol2qm74	1883	44	at	at	IN
cord-015021-pol2qm74	1883	45	different	different	JJ
cord-015021-pol2qm74	1883	46	times	time	NNS
cord-015021-pol2qm74	1883	47	,	,	,
cord-015021-pol2qm74	1883	48	only	only	RB
cord-015021-pol2qm74	1883	49	because	because	IN
cord-015021-pol2qm74	1883	50	each	each	DT
cord-015021-pol2qm74	1883	51	apparatus	apparatus	NN
cord-015021-pol2qm74	1883	52	has	have	VBZ
cord-015021-pol2qm74	1883	53	different	different	JJ
cord-015021-pol2qm74	1883	54	fimctienal	fimctienal	JJ
cord-015021-pol2qm74	1883	55	reserves	reserve	NNS
cord-015021-pol2qm74	1883	56	:	:	:
cord-015021-pol2qm74	1883	57	the	the	DT
cord-015021-pol2qm74	1883	58	lung	lung	NN
cord-015021-pol2qm74	1883	59	is	be	VBZ
cord-015021-pol2qm74	1883	60	the	the	DT
cord-015021-pol2qm74	1883	61	first	first	JJ
cord-015021-pol2qm74	1883	62	organ	organ	NN
cord-015021-pol2qm74	1883	63	to	to	TO
cord-015021-pol2qm74	1883	64	fail	fail	VB
cord-015021-pol2qm74	1883	65	just	just	RB
cord-015021-pol2qm74	1883	66	because	because	IN
cord-015021-pol2qm74	1883	67	its	-PRON-	PRP$
cord-015021-pol2qm74	1883	68	ah	ah	UH
cord-015021-pol2qm74	1883	69	,	,	,
cord-015021-pol2qm74	1883	70	celocapillary	celocapillary	NN
cord-015021-pol2qm74	1883	71	membrane	membrane	NN
cord-015021-pol2qm74	1883	72	is	be	VBZ
cord-015021-pol2qm74	1883	73	one	one	CD
cord-015021-pol2qm74	1883	74	of	of	IN
cord-015021-pol2qm74	1883	75	the	the	DT
cord-015021-pol2qm74	1883	76	most	most	RBS
cord-015021-pol2qm74	1883	77	delicate	delicate	JJ
cord-015021-pol2qm74	1883	78	bodily	bodily	JJ
cord-015021-pol2qm74	1883	79	structure	structure	NN
cord-015021-pol2qm74	1883	80	,	,	,
cord-015021-pol2qm74	1883	81	and	and	CC
cord-015021-pol2qm74	1883	82	its	-PRON-	PRP$
cord-015021-pol2qm74	1883	83	function	function	NN
cord-015021-pol2qm74	1883	84	is	be	VBZ
cord-015021-pol2qm74	1883	85	irroplace	irroplace	NNP
cord-015021-pol2qm74	1883	86	~	~	NNP
cord-015021-pol2qm74	1883	87	le	le	NNP
cord-015021-pol2qm74	1883	88	.	.	.
cord-015021-pol2qm74	1884	1	We	-PRON-	PRP
cord-015021-pol2qm74	1884	2	think	think	VBP
cord-015021-pol2qm74	1884	3	it	-PRON-	PRP
cord-015021-pol2qm74	1884	4	will	will	MD
cord-015021-pol2qm74	1884	5	be	be	VB
cord-015021-pol2qm74	1884	6	of	of	IN
cord-015021-pol2qm74	1884	7	a	a	DT
cord-015021-pol2qm74	1884	8	great	great	JJ
cord-015021-pol2qm74	1884	9	help	help	NN
cord-015021-pol2qm74	1884	10	,	,	,
cord-015021-pol2qm74	1884	11	in	in	IN
cord-015021-pol2qm74	1884	12	planning	plan	VBG
cord-015021-pol2qm74	1884	13	a	a	DT
cord-015021-pol2qm74	1884	14	preventive	preventive	JJ
cord-015021-pol2qm74	1884	15	therapy	therapy	NN
cord-015021-pol2qm74	1884	16	,	,	,
cord-015021-pol2qm74	1884	17	to	to	TO
cord-015021-pol2qm74	1884	18	chose	chose	VB
cord-015021-pol2qm74	1884	19	a	a	DT
cord-015021-pol2qm74	1884	20	denomination	denomination	NN
cord-015021-pol2qm74	1884	21	focusing	focus	VBG
cord-015021-pol2qm74	1884	22	the	the	DT
cord-015021-pol2qm74	1884	23	physician	physician	NN
cord-015021-pol2qm74	1884	24	's	's	POS
cord-015021-pol2qm74	1884	25	attention	attention	NN
cord-015021-pol2qm74	1884	26	on	on	IN
cord-015021-pol2qm74	1884	27	the	the	DT
cord-015021-pol2qm74	1884	28	earl	earl	NNP
cord-015021-pol2qm74	1884	29	)	)	-RRB-
cord-015021-pol2qm74	1884	30	"	"	``
cord-015021-pol2qm74	1884	31	generalized	generalize	VBD
cord-015021-pol2qm74	1884	32	endothelial	endothelial	JJ
cord-015021-pol2qm74	1884	33	injury	injury	NN
cord-015021-pol2qm74	1884	34	and	and	CC
cord-015021-pol2qm74	1884	35	its	-PRON-	PRP$
cord-015021-pol2qm74	1884	36	effects	effect	NNS
cord-015021-pol2qm74	1884	37	,	,	,
cord-015021-pol2qm74	1884	38	as	as	IN
cord-015021-pol2qm74	1884	39	in	in	IN
cord-015021-pol2qm74	1884	40	trauma	trauma	NN
cord-015021-pol2qm74	1884	41	patients	patient	NNS
cord-015021-pol2qm74	1884	42	it	-PRON-	PRP
cord-015021-pol2qm74	1884	43	is	be	VBZ
cord-015021-pol2qm74	1884	44	present	present	JJ
cord-015021-pol2qm74	1885	1	-even	-even	VBN
cord-015021-pol2qm74	1886	1	if	if	IN
cord-015021-pol2qm74	1886	2	latenflysince	latenflysince	NNP
cord-015021-pol2qm74	1886	3	the	the	DT
cord-015021-pol2qm74	1886	4	first	first	JJ
cord-015021-pol2qm74	1886	5	few	few	JJ
cord-015021-pol2qm74	1886	6	hours	hour	NNS
cord-015021-pol2qm74	1886	7	.	.	.
cord-015021-pol2qm74	1887	1	We	-PRON-	PRP
cord-015021-pol2qm74	1887	2	would	would	MD
cord-015021-pol2qm74	1887	3	like	like	VB
cord-015021-pol2qm74	1887	4	to	to	TO
cord-015021-pol2qm74	1887	5	see	see	VB
cord-015021-pol2qm74	1887	6	the	the	DT
cord-015021-pol2qm74	1887	7	generalised	generalised	JJ
cord-015021-pol2qm74	1887	8	endothelial	endothelial	JJ
cord-015021-pol2qm74	1887	9	microcircolatory	microcircolatory	NNP
cord-015021-pol2qm74	1887	10	injury	injury	NN
cord-015021-pol2qm74	1887	11	properly	properly	RB
cord-015021-pol2qm74	1887	12	highlighted	highlight	VBD
cord-015021-pol2qm74	1887	13	when	when	WRB
cord-015021-pol2qm74	1887	14	considering	consider	VBG
cord-015021-pol2qm74	1887	15	the	the	DT
cord-015021-pol2qm74	1887	16	best	good	JJS
cord-015021-pol2qm74	1887	17	definition	definition	NN
cord-015021-pol2qm74	1887	18	and	and	CC
cord-015021-pol2qm74	1887	19	the	the	DT
cord-015021-pol2qm74	1887	20	optimal	optimal	JJ
cord-015021-pol2qm74	1887	21	nomenclature	nomenclature	NN
cord-015021-pol2qm74	1887	22	for	for	IN
cord-015021-pol2qm74	1887	23	the	the	DT
cord-015021-pol2qm74	1887	24	post	post	JJ
cord-015021-pol2qm74	1887	25	-	-	JJ
cord-015021-pol2qm74	1887	26	traumatic	traumatic	JJ
cord-015021-pol2qm74	1887	27	s3mdrome	s3mdrome	NNS
cord-015021-pol2qm74	1887	28	.	.	.
cord-015021-pol2qm74	1888	1	The	the	DT
cord-015021-pol2qm74	1888	2	presence	presence	NN
cord-015021-pol2qm74	1888	3	of	of	IN
cord-015021-pol2qm74	1888	4	interleukin	interleukin	NN
cord-015021-pol2qm74	1888	5	(	(	-LRB-
cord-015021-pol2qm74	1888	6	IL)-8	IL)-8	NNP
cord-015021-pol2qm74	1888	7	in	in	IN
cord-015021-pol2qm74	1888	8	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	1888	9	lavage	lavage	NN
cord-015021-pol2qm74	1888	10	fluid	fluid	NN
cord-015021-pol2qm74	1888	11	of	of	IN
cord-015021-pol2qm74	1888	12	critically	critically	RB
cord-015021-pol2qm74	1888	13	ill	ill	JJ
cord-015021-pol2qm74	1888	14	patients	patient	NNS
cord-015021-pol2qm74	1888	15	correlates	correlate	VBZ
cord-015021-pol2qm74	1888	16	clinically	clinically	RB
cord-015021-pol2qm74	1888	17	with	with	IN
cord-015021-pol2qm74	1888	18	the	the	DT
cord-015021-pol2qm74	1888	19	development	development	NN
cord-015021-pol2qm74	1888	20	of	of	IN
cord-015021-pol2qm74	1888	21	the	the	DT
cord-015021-pol2qm74	1888	22	adult	adult	NN
cord-015021-pol2qm74	1888	23	respiratory	respiratory	JJ
cord-015021-pol2qm74	1888	24	distress	distress	NN
cord-015021-pol2qm74	1888	25	syndrome	syndrome	NN
cord-015021-pol2qm74	1888	26	lARDS	lARDS	NNP
cord-015021-pol2qm74	1888	27	)	)	-RRB-
cord-015021-pol2qm74	1888	28	,	,	,
cord-015021-pol2qm74	1888	29	and	and	CC
cord-015021-pol2qm74	1888	30	inhibition	inhibition	NN
cord-015021-pol2qm74	1888	31	of	of	IN
cord-015021-pol2qm74	1888	32	IL-8	il-8	NN
cord-015021-pol2qm74	1888	33	in	in	IN
cord-015021-pol2qm74	1888	34	animal	animal	NN
cord-015021-pol2qm74	1888	35	models	model	NNS
cord-015021-pol2qm74	1888	36	can	can	MD
cord-015021-pol2qm74	1888	37	attenuate	attenuate	VB
cord-015021-pol2qm74	1888	38	lung	lung	NN
cord-015021-pol2qm74	1888	39	injury	injury	NN
cord-015021-pol2qm74	1888	40	.	.	.
cord-015021-pol2qm74	1889	1	Collectively	collectively	RB
cord-015021-pol2qm74	1889	2	,	,	,
cord-015021-pol2qm74	1889	3	evidence	evidence	NN
cord-015021-pol2qm74	1889	4	to	to	IN
cord-015021-pol2qm74	1889	5	date	date	NN
cord-015021-pol2qm74	1889	6	suggests	suggest	VBZ
cord-015021-pol2qm74	1889	7	that	that	IN
cord-015021-pol2qm74	1889	8	IL-8	IL-8	NNP
cord-015021-pol2qm74	1889	9	attracts	attract	VBZ
cord-015021-pol2qm74	1889	10	and	and	CC
cord-015021-pol2qm74	1889	11	activates	activate	VBZ
cord-015021-pol2qm74	1889	12	neutrophiis	neutrophiis	JJ
cord-015021-pol2qm74	1889	13	(	(	-LRB-
cord-015021-pol2qm74	1889	14	PMN	PMN	NNP
cord-015021-pol2qm74	1889	15	)	)	-RRB-
cord-015021-pol2qm74	1889	16	,	,	,
cord-015021-pol2qm74	1889	17	which	which	WDT
cord-015021-pol2qm74	1889	18	are	be	VBP
cord-015021-pol2qm74	1889	19	then	then	RB
cord-015021-pol2qm74	1889	20	responsible	responsible	JJ
cord-015021-pol2qm74	1889	21	for	for	IN
cord-015021-pol2qm74	1889	22	the	the	DT
cord-015021-pol2qm74	1889	23	capillary	capillary	JJ
cord-015021-pol2qm74	1889	24	leak	leak	NN
cord-015021-pol2qm74	1889	25	of	of	IN
cord-015021-pol2qm74	1889	26	ARDS	ARDS	NNP
cord-015021-pol2qm74	1889	27	.	.	.
cord-015021-pol2qm74	1890	1	However	however	RB
cord-015021-pol2qm74	1890	2	,	,	,
cord-015021-pol2qm74	1890	3	an	an	DT
cord-015021-pol2qm74	1890	4	alternative	alternative	JJ
cord-015021-pol2qm74	1890	5	explanation	explanation	NN
cord-015021-pol2qm74	1890	6	is	be	VBZ
cord-015021-pol2qm74	1890	7	that	that	IN
cord-015021-pol2qm74	1890	8	IL-8	IL-8	NNP
cord-015021-pol2qm74	1890	9	is	be	VBZ
cord-015021-pol2qm74	1890	10	directly	directly	RB
cord-015021-pol2qm74	1890	11	toxic	toxic	JJ
cord-015021-pol2qm74	1890	12	to	to	IN
cord-015021-pol2qm74	1890	13	the	the	DT
cord-015021-pol2qm74	1890	14	endothelial	endothelial	JJ
cord-015021-pol2qm74	1890	15	cell	cell	NN
cord-015021-pol2qm74	1890	16	(	(	-LRB-
cord-015021-pol2qm74	1890	17	EC	EC	NNP
cord-015021-pol2qm74	1890	18	)	)	-RRB-
cord-015021-pol2qm74	1890	19	.	.	.
cord-015021-pol2qm74	1891	1	In	in	IN
cord-015021-pol2qm74	1891	2	this	this	DT
cord-015021-pol2qm74	1891	3	study	study	NN
cord-015021-pol2qm74	1891	4	,	,	,
cord-015021-pol2qm74	1891	5	we	-PRON-	PRP
cord-015021-pol2qm74	1891	6	have	have	VBP
cord-015021-pol2qm74	1891	7	hypothesized	hypothesize	VBN
cord-015021-pol2qm74	1891	8	that	that	IN
cord-015021-pol2qm74	1891	9	IL-8	IL-8	NNP
cord-015021-pol2qm74	1891	10	can	can	MD
cord-015021-pol2qm74	1891	11	disrupt	disrupt	VB
cord-015021-pol2qm74	1891	12	endothelial	endothelial	JJ
cord-015021-pol2qm74	1891	13	integrity	integrity	NN
cord-015021-pol2qm74	1891	14	independent	independent	JJ
cord-015021-pol2qm74	1891	15	of	of	IN
cord-015021-pol2qm74	1891	16	PMN	PMN	NNP
cord-015021-pol2qm74	1891	17	.	.	.
cord-015021-pol2qm74	1892	1	Meth	meth	JJ
cord-015021-pol2qm74	1892	2	ods	od	NNS
cord-015021-pol2qm74	1892	3	:	:	:
cord-015021-pol2qm74	1892	4	Human	human	JJ
cord-015021-pol2qm74	1892	5	umbilical	umbilical	JJ
cord-015021-pol2qm74	1892	6	vein	vein	NN
cord-015021-pol2qm74	1892	7	(	(	-LRB-
cord-015021-pol2qm74	1892	8	HUV	HUV	NNP
cord-015021-pol2qm74	1892	9	)	)	-RRB-
cord-015021-pol2qm74	1892	10	EC	EC	NNP
cord-015021-pol2qm74	1892	11	monolayers	monolayer	NNS
cord-015021-pol2qm74	1892	12	were	be	VBD
cord-015021-pol2qm74	1892	13	cultured	cultured	JJ
cord-015021-pol2qm74	1892	14	to	to	IN
cord-015021-pol2qm74	1892	15	confluency	confluency	NN
cord-015021-pol2qm74	1892	16	on	on	IN
cord-015021-pol2qm74	1892	17	collagen	collagen	NN
cord-015021-pol2qm74	1892	18	-	-	HYPH
cord-015021-pol2qm74	1892	19	coated	coat	VBN
cord-015021-pol2qm74	1892	20	micropore	micropore	NN
cord-015021-pol2qm74	1892	21	filters	filter	NNS
cord-015021-pol2qm74	1892	22	.	.	.
cord-015021-pol2qm74	1893	1	To	to	TO
cord-015021-pol2qm74	1893	2	assess	assess	VB
cord-015021-pol2qm74	1893	3	EC	EC	NNP
cord-015021-pol2qm74	1893	4	integrity	integrity	NN
cord-015021-pol2qm74	1893	5	,	,	,
cord-015021-pol2qm74	1893	6	1251.albumi	1251.albumi	CD
cord-015021-pol2qm74	1893	7	n	n	CD
cord-015021-pol2qm74	1893	8	leak	leak	NN
cord-015021-pol2qm74	1893	9	was	be	VBD
cord-015021-pol2qm74	1893	10	quantitated	quantitate	VBN
cord-015021-pol2qm74	1893	11	by	by	IN
cord-015021-pol2qm74	1893	12	measuring	measure	VBG
cord-015021-pol2qm74	1893	13	the	the	DT
cord-015021-pol2qm74	1893	14	1251	1251	CD
cord-015021-pol2qm74	1893	15	counts	count	NNS
cord-015021-pol2qm74	1893	16	which	which	WDT
cord-015021-pol2qm74	1893	17	crossed	cross	VBD
cord-015021-pol2qm74	1893	18	the	the	DT
cord-015021-pol2qm74	1893	19	monolayer	monolayer	NN
cord-015021-pol2qm74	1893	20	,	,	,
cord-015021-pol2qm74	1893	21	using	use	VBG
cord-015021-pol2qm74	1893	22	a	a	DT
cord-015021-pol2qm74	1893	23	gamma	gamma	NN
cord-015021-pol2qm74	1893	24	counter	counter	NN
cord-015021-pol2qm74	1893	25	.	.	.
cord-015021-pol2qm74	1894	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	1895	1	(	(	-LRB-
cord-015021-pol2qm74	1895	2	lpg	lpg	NNP
cord-015021-pol2qm74	1895	3	/	/	SYM
cord-015021-pol2qm74	1895	4	ml	ml	NNP
cord-015021-pol2qm74	1895	5	)	)	-RRB-
cord-015021-pol2qm74	1895	6	was	be	VBD
cord-015021-pol2qm74	1895	7	incubated	incubate	VBN
cord-015021-pol2qm74	1895	8	in	in	IN
cord-015021-pol2qm74	1895	9	the	the	DT
cord-015021-pol2qm74	1895	10	culture	culture	NN
cord-015021-pol2qm74	1895	11	medium	medium	NN
cord-015021-pol2qm74	1895	12	with	with	IN
cord-015021-pol2qm74	1895	13	1251.albumi	1251.albumi	CD
cord-015021-pol2qm74	1895	14	n	n	NN
cord-015021-pol2qm74	1895	15	for	for	IN
cord-015021-pol2qm74	1895	16	21	21	CD
cord-015021-pol2qm74	1895	17	hrs	hrs	NN
cord-015021-pol2qm74	1895	18	.	.	.
cord-015021-pol2qm74	1896	1	The	the	DT
cord-015021-pol2qm74	1896	2	IL-8	IL-8	NNP
cord-015021-pol2qm74	1896	3	dose	dose	NN
cord-015021-pol2qm74	1896	4	was	be	VBD
cord-015021-pol2qm74	1896	5	not	not	RB
cord-015021-pol2qm74	1896	6	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	1896	7	.	.	.
cord-015021-pol2qm74	1897	1	To	to	TO
cord-015021-pol2qm74	1897	2	determine	determine	VB
cord-015021-pol2qm74	1897	3	the	the	DT
cord-015021-pol2qm74	1897	4	involvement	involvement	NN
cord-015021-pol2qm74	1897	5	of	of	IN
cord-015021-pol2qm74	1897	6	protein	protein	NN
cord-015021-pol2qm74	1897	7	synthesis	synthesis	NN
cord-015021-pol2qm74	1897	8	in	in	IN
cord-015021-pol2qm74	1897	9	this	this	DT
cord-015021-pol2qm74	1897	10	process	process	NN
cord-015021-pol2qm74	1897	11	,	,	,
cord-015021-pol2qm74	1897	12	selected	select	VBN
cord-015021-pol2qm74	1897	13	monolayers	monolayer	NNS
cord-015021-pol2qm74	1897	14	were	be	VBD
cord-015021-pol2qm74	1897	15	pretreated	pretreate	VBN
cord-015021-pol2qm74	1897	16	with	with	IN
cord-015021-pol2qm74	1897	17	cycloheximide	cycloheximide	NN
cord-015021-pol2qm74	1897	18	(	(	-LRB-
cord-015021-pol2qm74	1897	19	CH	CH	NNP
cord-015021-pol2qm74	1897	20	)	)	-RRB-
cord-015021-pol2qm74	1897	21	prior	prior	RB
cord-015021-pol2qm74	1897	22	to	to	IN
cord-015021-pol2qm74	1897	23	11.-8	11.-8	CD
cord-015021-pol2qm74	1897	24	addition	addition	NN
cord-015021-pol2qm74	1897	25	.	.	.
cord-015021-pol2qm74	1898	1	Statistical	statistical	JJ
cord-015021-pol2qm74	1898	2	analysis	analysis	NN
cord-015021-pol2qm74	1898	3	was	be	VBD
cord-015021-pol2qm74	1898	4	performed	perform	VBN
cord-015021-pol2qm74	1898	5	using	use	VBG
cord-015021-pol2qm74	1898	6	ANOVMFisher	ANOVMFisher	NNP
cord-015021-pol2qm74	1898	7	PLSD	PLSD	NNP
cord-015021-pol2qm74	1898	8	.	.	.
cord-015021-pol2qm74	1899	1	We	-PRON-	PRP
cord-015021-pol2qm74	1899	2	have	have	VBP
cord-015021-pol2qm74	1899	3	previously	previously	RB
cord-015021-pol2qm74	1899	4	shown	show	VBN
cord-015021-pol2qm74	1899	5	that	that	IN
cord-015021-pol2qm74	1899	6	Platelet	platelet	NN
cord-015021-pol2qm74	1899	7	Activating	Activating	NNP
cord-015021-pol2qm74	1899	8	Factor	Factor	NNP
cord-015021-pol2qm74	1899	9	(	(	-LRB-
cord-015021-pol2qm74	1899	10	PAF	PAF	NNP
cord-015021-pol2qm74	1899	11	)	)	-RRB-
cord-015021-pol2qm74	1899	12	enhances	enhance	VBZ
cord-015021-pol2qm74	1899	13	CDt8	cdt8	JJ
cord-015021-pol2qm74	1899	14	expression	expression	NN
cord-015021-pol2qm74	1899	15	and	and	CC
cord-015021-pol2qm74	1899	16	primes	prime	VBZ
cord-015021-pol2qm74	1899	17	PMN	PMN	NNP
cord-015021-pol2qm74	1899	18	's	's	POS
cord-015021-pol2qm74	1899	19	for	for	IN
cord-015021-pol2qm74	1899	20	subsequent	subsequent	JJ
cord-015021-pol2qm74	1899	21	02generation	02generation	NN
cord-015021-pol2qm74	1899	22	.	.	.
cord-015021-pol2qm74	1900	1	Both	both	DT
cord-015021-pol2qm74	1900	2	are	be	VBP
cord-015021-pol2qm74	1900	3	important	important	JJ
cord-015021-pol2qm74	1900	4	steps	step	NNS
cord-015021-pol2qm74	1900	5	in	in	IN
cord-015021-pol2qm74	1900	6	PMN	PMN	NNP
cord-015021-pol2qm74	1900	7	mediated	mediate	VBD
cord-015021-pol2qm74	1900	8	injury	injury	NN
cord-015021-pol2qm74	1900	9	and	and	CC
cord-015021-pol2qm74	1900	10	are	be	VBP
cord-015021-pol2qm74	1900	11	assumed	assume	VBN
cord-015021-pol2qm74	1900	12	to	to	TO
cord-015021-pol2qm74	1900	13	occur	occur	VB
cord-015021-pol2qm74	1900	14	in	in	IN
cord-015021-pol2qm74	1900	15	concert	concert	NN
cord-015021-pol2qm74	1900	16	.	.	.
cord-015021-pol2qm74	1901	1	Following	follow	VBG
cord-015021-pol2qm74	1901	2	major	major	JJ
cord-015021-pol2qm74	1901	3	trauma	trauma	NN
cord-015021-pol2qm74	1901	4	non	non	JJ
cord-015021-pol2qm74	1901	5	-	-	JJ
cord-015021-pol2qm74	1901	6	specific	specific	JJ
cord-015021-pol2qm74	1901	7	PMN	PMN	NNP
cord-015021-pol2qm74	1901	8	inflammation	inflammation	NN
cord-015021-pol2qm74	1901	9	is	be	VBZ
cord-015021-pol2qm74	1901	10	activated	activate	VBN
cord-015021-pol2qm74	1901	11	,	,	,
cord-015021-pol2qm74	1901	12	however	however	RB
cord-015021-pol2qm74	1901	13	,	,	,
cord-015021-pol2qm74	1901	14	unbridled	unbridled	JJ
cord-015021-pol2qm74	1901	15	systemic	systemic	JJ
cord-015021-pol2qm74	1901	16	PMN	pmn	NN
cord-015021-pol2qm74	1901	17	activity	activity	NN
cord-015021-pol2qm74	1901	18	needs	need	VBZ
cord-015021-pol2qm74	1901	19	to	to	TO
cord-015021-pol2qm74	1901	20	be	be	VB
cord-015021-pol2qm74	1901	21	minimized	minimize	VBN
cord-015021-pol2qm74	1901	22	.	.	.
cord-015021-pol2qm74	1902	1	Since	since	IN
cord-015021-pol2qm74	1902	2	circulating	circulate	VBG
cord-015021-pol2qm74	1902	3	catecholamines	catecholamine	NNS
cord-015021-pol2qm74	1902	4	are	be	VBP
cord-015021-pol2qm74	1902	5	high	high	JJ
cord-015021-pol2qm74	1902	6	early	early	JJ
cord-015021-pol2qm74	1902	7	post	post	JJ
cord-015021-pol2qm74	1902	8	-	-	JJ
cord-015021-pol2qm74	1902	9	injury	injury	NN
cord-015021-pol2qm74	1902	10	,	,	,
cord-015021-pol2qm74	1902	11	we	-PRON-	PRP
cord-015021-pol2qm74	1902	12	hypothesised	hypothesise	VBD
cord-015021-pol2qm74	1902	13	that	that	IN
cord-015021-pol2qm74	1902	14	they	-PRON-	PRP
cord-015021-pol2qm74	1902	15	downregu	downregu	RB
cord-015021-pol2qm74	1902	16	/	/	SYM
cord-015021-pol2qm74	1902	17	ate	eat	VBD
cord-015021-pol2qm74	1902	18	CD	CD	NNP
cord-015021-pol2qm74	1902	19	18	18	CD
cord-015021-pol2qm74	1902	20	expression	expression	NN
cord-015021-pol2qm74	1902	21	and	and	CC
cord-015021-pol2qm74	1902	22	PMN	PMN	NNP
cord-015021-pol2qm74	1902	23	priming	prime	VBG
cord-015021-pol2qm74	1902	24	via	via	IN
cord-015021-pol2qm74	1902	25	the	the	DT
cord-015021-pol2qm74	1902	26	[	[	-LRB-
cord-015021-pol2qm74	1902	27	3	3	CD
cord-015021-pol2qm74	1902	28	adrenergic	adrenergic	NN
cord-015021-pol2qm74	1902	29	signal	signal	NN
cord-015021-pol2qm74	1902	30	transduction	transduction	NN
cord-015021-pol2qm74	1902	31	pathway	pathway	NN
cord-015021-pol2qm74	1902	32	.	.	.
cord-015021-pol2qm74	1903	1	Methods	method	NNS
cord-015021-pol2qm74	1903	2	:	:	:
cord-015021-pol2qm74	1903	3	Normal	normal	JJ
cord-015021-pol2qm74	1903	4	human	human	JJ
cord-015021-pol2qm74	1903	5	PMNs	pmn	NNS
cord-015021-pol2qm74	1903	6	were	be	VBD
cord-015021-pol2qm74	1903	7	primed	prime	VBN
cord-015021-pol2qm74	1903	8	with	with	IN
cord-015021-pol2qm74	1903	9	PAF	PAF	NNP
cord-015021-pol2qm74	1903	10	(	(	-LRB-
cord-015021-pol2qm74	1903	11	10ng	10ng	NN
cord-015021-pol2qm74	1903	12	/	/	SYM
cord-015021-pol2qm74	1903	13	ml	ml	NN
cord-015021-pol2qm74	1903	14	for	for	IN
cord-015021-pol2qm74	1903	15	5	5	CD
cord-015021-pol2qm74	1903	16	min	min	NNP
cord-015021-pol2qm74	1903	17	)	)	-RRB-
cord-015021-pol2qm74	1903	18	or	or	CC
cord-015021-pol2qm74	1903	19	pre	pre	VB
cord-015021-pol2qm74	1903	20	-	-	VBN
cord-015021-pol2qm74	1903	21	treated	treat	VBN
cord-015021-pol2qm74	1903	22	with	with	IN
cord-015021-pol2qm74	1903	23	10	10	CD
cord-015021-pol2qm74	1903	24	-	-	SYM
cord-015021-pol2qm74	1903	25	5	5	CD
cord-015021-pol2qm74	1903	26	M	M	NNP
cord-015021-pol2qm74	1903	27	of	of	IN
cord-015021-pol2qm74	1903	28	Isoproterenol	Isoproterenol	NNP
cord-015021-pol2qm74	1903	29	(	(	-LRB-
cord-015021-pol2qm74	1903	30	I	i	NN
cord-015021-pol2qm74	1903	31	)	)	-RRB-
cord-015021-pol2qm74	1903	32	or	or	CC
cord-015021-pol2qm74	1903	33	Forskoklin	Forskoklin	NNP
cord-015021-pol2qm74	1903	34	(	(	-LRB-
cord-015021-pol2qm74	1903	35	F	F	NNP
cord-015021-pol2qm74	1903	36	)	)	-RRB-
cord-015021-pol2qm74	1903	37	for	for	IN
cord-015021-pol2qm74	1903	38	5	5	CD
cord-015021-pol2qm74	1903	39	rain	rain	NN
cord-015021-pol2qm74	1903	40	and	and	CC
cord-015021-pol2qm74	1903	41	then	then	RB
cord-015021-pol2qm74	1903	42	primed	prime	VBN
cord-015021-pol2qm74	1903	43	with	with	IN
cord-015021-pol2qm74	1903	44	PAF	PAF	NNP
cord-015021-pol2qm74	1903	45	.	.	.
cord-015021-pol2qm74	1904	1	CD18	CD18	NNP
cord-015021-pol2qm74	1904	2	expression	expression	NN
cord-015021-pol2qm74	1904	3	was	be	VBD
cord-015021-pol2qm74	1904	4	measured	measure	VBN
cord-015021-pol2qm74	1904	5	by	by	IN
cord-015021-pol2qm74	1904	6	flow	flow	NN
cord-015021-pol2qm74	1904	7	cytometry	cytometry	NN
cord-015021-pol2qm74	1904	8	(	(	-LRB-
cord-015021-pol2qm74	1904	9	Fig.l	Fig.l	NNP
cord-015021-pol2qm74	1904	10	)	)	-RRB-
cord-015021-pol2qm74	1904	11	and	and	CC
cord-015021-pol2qm74	1904	12	02-generation	02-generation	CD
cord-015021-pol2qm74	1905	1	in	in	IN
cord-015021-pol2qm74	1905	2	response	response	NN
cord-015021-pol2qm74	1905	3	to	to	IN
cord-015021-pol2qm74	1905	4	10-rM	10-rm	CD
cord-015021-pol2qm74	1905	5	fMLP	fMLP	NNS
cord-015021-pol2qm74	1905	6	was	be	VBD
cord-015021-pol2qm74	1905	7	determined	determine	VBN
cord-015021-pol2qm74	1905	8	as	as	IN
cord-015021-pol2qm74	1905	9	SOD	SOD	NNP
cord-015021-pol2qm74	1905	10	inhibitable	inhibitable	JJ
cord-015021-pol2qm74	1905	11	reduction	reduction	NN
cord-015021-pol2qm74	1905	12	of	of	IN
cord-015021-pol2qm74	1905	13	cytochrome	cytochrome	NN
cord-015021-pol2qm74	1905	14	C	c	NN
cord-015021-pol2qm74	1905	15	(	(	-LRB-
cord-015021-pol2qm74	1905	16	Fig.2	Fig.2	NNP
cord-015021-pol2qm74	1906	1	Holler	Holler	NNP
cord-015021-pol2qm74	1907	1	*	*	NFP
cord-015021-pol2qm74	1907	2	*	*	NFP
cord-015021-pol2qm74	1907	3	and	and	CC
cord-015021-pol2qm74	1907	4	Georg	Georg	NNP
cord-015021-pol2qm74	1907	5	W.	W.	NNP
cord-015021-pol2qm74	1907	6	Bornkamm	Bornkamm	NNP
cord-015021-pol2qm74	1908	1	*	*	NFP
cord-015021-pol2qm74	1908	2	Lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	1908	3	-	-	HYPH
cord-015021-pol2qm74	1908	4	endothelial	endothelial	JJ
cord-015021-pol2qm74	1908	5	interactions	interaction	NNS
cord-015021-pol2qm74	1908	6	are	be	VBP
cord-015021-pol2qm74	1908	7	crucial	crucial	JJ
cord-015021-pol2qm74	1908	8	for	for	IN
cord-015021-pol2qm74	1908	9	various	various	JJ
cord-015021-pol2qm74	1908	10	immune	immune	JJ
cord-015021-pol2qm74	1908	11	responses	response	NNS
cord-015021-pol2qm74	1908	12	,	,	,
cord-015021-pol2qm74	1908	13	including	include	VBG
cord-015021-pol2qm74	1908	14	cytokine	cytokine	NN
cord-015021-pol2qm74	1908	15	driven	drive	VBD
cord-015021-pol2qm74	1908	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1908	17	processes	process	NNS
cord-015021-pol2qm74	1908	18	.	.	.
cord-015021-pol2qm74	1909	1	Protein	protein	NN
cord-015021-pol2qm74	1909	2	kinase	kinase	NN
cord-015021-pol2qm74	1909	3	C	C	NNP
cord-015021-pol2qm74	1909	4	(	(	-LRB-
cord-015021-pol2qm74	1909	5	PKC)-inhibitors	pkc)-inhibitor	NNS
cord-015021-pol2qm74	1909	6	on	on	IN
cord-015021-pol2qm74	1909	7	the	the	DT
cord-015021-pol2qm74	1909	8	other	other	JJ
cord-015021-pol2qm74	1909	9	hand	hand	NN
cord-015021-pol2qm74	1909	10	are	be	VBP
cord-015021-pol2qm74	1909	11	discussed	discuss	VBN
cord-015021-pol2qm74	1909	12	as	as	IN
cord-015021-pol2qm74	1909	13	potential	potential	JJ
cord-015021-pol2qm74	1909	14	cytokine	cytokine	NN
cord-015021-pol2qm74	1909	15	antagonists	antagonist	NNS
cord-015021-pol2qm74	1909	16	.	.	.
cord-015021-pol2qm74	1910	1	In	in	IN
cord-015021-pol2qm74	1910	2	the	the	DT
cord-015021-pol2qm74	1910	3	present	present	JJ
cord-015021-pol2qm74	1910	4	study	study	NN
cord-015021-pol2qm74	1910	5	we	-PRON-	PRP
cord-015021-pol2qm74	1910	6	investigated	investigate	VBD
cord-015021-pol2qm74	1910	7	the	the	DT
cord-015021-pol2qm74	1910	8	influence	influence	NN
cord-015021-pol2qm74	1910	9	of	of	IN
cord-015021-pol2qm74	1910	10	the	the	DT
cord-015021-pol2qm74	1910	11	PKC	PKC	NNP
cord-015021-pol2qm74	1910	12	-	-	HYPH
cord-015021-pol2qm74	1910	13	inhibitor	inhibitor	NN
cord-015021-pol2qm74	1910	14	GF109203X	GF109203X	NNP
cord-015021-pol2qm74	1910	15	on	on	IN
cord-015021-pol2qm74	1910	16	cytokine	cytokine	NN
cord-015021-pol2qm74	1910	17	-	-	HYPH
cord-015021-pol2qm74	1910	18	and	and	CC
cord-015021-pol2qm74	1910	19	endotoxin	endotoxin	NN
cord-015021-pol2qm74	1910	20	induced	induce	VBN
cord-015021-pol2qm74	1910	21	expression	expression	NN
cord-015021-pol2qm74	1910	22	of	of	IN
cord-015021-pol2qm74	1910	23	intercellular	intercellular	JJ
cord-015021-pol2qm74	1910	24	adhesion	adhesion	NN
cord-015021-pol2qm74	1910	25	molecule	molecule	NN
cord-015021-pol2qm74	1910	26	1	1	CD
cord-015021-pol2qm74	1910	27	(	(	-LRB-
cord-015021-pol2qm74	1910	28	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	1910	29	)	)	-RRB-
cord-015021-pol2qm74	1910	30	and	and	CC
cord-015021-pol2qm74	1910	31	on	on	IN
cord-015021-pol2qm74	1910	32	adhesion	adhesion	NN
cord-015021-pol2qm74	1910	33	of	of	IN
cord-015021-pol2qm74	1910	34	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	1910	35	to	to	TO
cord-015021-pol2qm74	1910	36	cytokine	cytokine	VB
cord-015021-pol2qm74	1910	37	activated	activate	VBN
cord-015021-pol2qm74	1910	38	endothelial	endothelial	JJ
cord-015021-pol2qm74	1910	39	cells	cell	NNS
cord-015021-pol2qm74	1910	40	.	.	.
cord-015021-pol2qm74	1911	1	We	-PRON-	PRP
cord-015021-pol2qm74	1911	2	found	find	VBD
cord-015021-pol2qm74	1911	3	that	that	IN
cord-015021-pol2qm74	1911	4	Tumor	tumor	NN
cord-015021-pol2qm74	1911	5	necrosis	necrosis	NN
cord-015021-pol2qm74	1911	6	factor	factor	NN
cord-015021-pol2qm74	1911	7	alpha	alpha	NN
cord-015021-pol2qm74	1912	1	(	(	-LRB-
cord-015021-pol2qm74	1912	2	TNFo0-and	tnfo0-and	DT
cord-015021-pol2qm74	1913	1	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-015021-pol2qm74	1913	2	(	(	-LRB-
cord-015021-pol2qm74	1913	3	LPS)-induced	lps)-induced	JJ
cord-015021-pol2qm74	1913	4	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1913	5	expression	expression	NN
cord-015021-pol2qm74	1913	6	on	on	IN
cord-015021-pol2qm74	1913	7	human	human	JJ
cord-015021-pol2qm74	1913	8	endothelioma	endothelioma	NNS
cord-015021-pol2qm74	1913	9	celts	celts	NNPS
cord-015021-pol2qm74	1913	10	(	(	-LRB-
cord-015021-pol2qm74	1913	11	EAhy926	EAhy926	NNP
cord-015021-pol2qm74	1913	12	)	)	-RRB-
cord-015021-pol2qm74	1913	13	were	be	VBD
cord-015021-pol2qm74	1913	14	unaffected	unaffected	JJ
cord-015021-pol2qm74	1913	15	by	by	IN
cord-015021-pol2qm74	1913	16	the	the	DT
cord-015021-pol2qm74	1913	17	PKC	PKC	NNP
cord-015021-pol2qm74	1913	18	-	-	HYPH
cord-015021-pol2qm74	1913	19	inhibitor	inhibitor	NN
cord-015021-pol2qm74	1913	20	and	and	CC
cord-015021-pol2qm74	1913	21	thus	thus	RB
cord-015021-pol2qm74	1913	22	appeared	appear	VBD
cord-015021-pol2qm74	1913	23	to	to	TO
cord-015021-pol2qm74	1913	24	be	be	VB
cord-015021-pol2qm74	1913	25	independent	independent	JJ
cord-015021-pol2qm74	1913	26	of	of	IN
cord-015021-pol2qm74	1913	27	PKC	PKC	NNP
cord-015021-pol2qm74	1913	28	activation	activation	NN
cord-015021-pol2qm74	1913	29	.	.	.
cord-015021-pol2qm74	1914	1	In	in	IN
cord-015021-pol2qm74	1914	2	contrast	contrast	NN
cord-015021-pol2qm74	1914	3	,	,	,
cord-015021-pol2qm74	1914	4	GF109203X	GF109203X	NNP
cord-015021-pol2qm74	1914	5	significantly	significantly	RB
cord-015021-pol2qm74	1914	6	reduced	reduce	VBN
cord-015021-pol2qm74	1914	7	ICAM-1	icam-1	NN
cord-015021-pol2qm74	1914	8	expression	expression	NN
cord-015021-pol2qm74	1914	9	induced	induce	VBN
cord-015021-pol2qm74	1914	10	by	by	IN
cord-015021-pol2qm74	1914	11	Interferon	Interferon	NNP
cord-015021-pol2qm74	1914	12	-	-	HYPH
cord-015021-pol2qm74	1914	13	y	y	NNP
cord-015021-pol2qm74	1914	14	(	(	-LRB-
cord-015021-pol2qm74	1914	15	IFN-	IFN-	NNP
cord-015021-pol2qm74	1914	16	?	?	.
cord-015021-pol2qm74	1914	17	)	)	-RRB-
cord-015021-pol2qm74	1915	1	and	and	CC
cord-015021-pol2qm74	1915	2	Interleukin-1	Interleukin-1	NNP
cord-015021-pol2qm74	1915	3	(	(	-LRB-
cord-015021-pol2qm74	1915	4	IL-1	IL-1	NNP
cord-015021-pol2qm74	1915	5	)	)	-RRB-
cord-015021-pol2qm74	1915	6	.	.	.
cord-015021-pol2qm74	1916	1	The	the	DT
cord-015021-pol2qm74	1916	2	functional	functional	JJ
cord-015021-pol2qm74	1916	3	relevance	relevance	NN
cord-015021-pol2qm74	1916	4	of	of	IN
cord-015021-pol2qm74	1916	5	these	these	DT
cord-015021-pol2qm74	1916	6	findings	finding	NNS
cord-015021-pol2qm74	1916	7	was	be	VBD
cord-015021-pol2qm74	1916	8	evaluated	evaluate	VBN
cord-015021-pol2qm74	1916	9	in	in	IN
cord-015021-pol2qm74	1916	10	an	an	DT
cord-015021-pol2qm74	1916	11	adhesion	adhesion	NN
cord-015021-pol2qm74	1916	12	assay	assay	NN
cord-015021-pol2qm74	1916	13	using	use	VBG
cord-015021-pol2qm74	1916	14	human	human	JJ
cord-015021-pol2qm74	1916	15	umbilical	umbilical	JJ
cord-015021-pol2qm74	1916	16	vene	vene	NNP
cord-015021-pol2qm74	1916	17	endothelial	endothelial	JJ
cord-015021-pol2qm74	1916	18	cells	cell	NNS
cord-015021-pol2qm74	1916	19	(	(	-LRB-
cord-015021-pol2qm74	1916	20	HUVEC	HUVEC	NNP
cord-015021-pol2qm74	1916	21	)	)	-RRB-
cord-015021-pol2qm74	1916	22	and	and	CC
cord-015021-pol2qm74	1916	23	peripheral	peripheral	JJ
cord-015021-pol2qm74	1916	24	blood	blood	NN
cord-015021-pol2qm74	1916	25	mononuclear	mononuclear	NN
cord-015021-pol2qm74	1916	26	cells	cell	NNS
cord-015021-pol2qm74	1916	27	(	(	-LRB-
cord-015021-pol2qm74	1916	28	PBMC	PBMC	NNP
cord-015021-pol2qm74	1916	29	)	)	-RRB-
cord-015021-pol2qm74	1916	30	.	.	.
cord-015021-pol2qm74	1917	1	In	in	IN
cord-015021-pol2qm74	1917	2	fact	fact	NN
cord-015021-pol2qm74	1917	3	,	,	,
cord-015021-pol2qm74	1917	4	the	the	DT
cord-015021-pol2qm74	1917	5	IFN-	IFN-	NNP
cord-015021-pol2qm74	1917	6	?	?	.
cord-015021-pol2qm74	1917	7	and	and	CC
cord-015021-pol2qm74	1917	8	IL-1	IL-1	NNP
cord-015021-pol2qm74	1917	9	induced	induce	VBD
cord-015021-pol2qm74	1917	10	adhesion	adhesion	NN
cord-015021-pol2qm74	1917	11	of	of	IN
cord-015021-pol2qm74	1917	12	PBMC	PBMC	NNP
cord-015021-pol2qm74	1917	13	to	to	TO
cord-015021-pol2qm74	1917	14	cytokine	cytokine	VB
cord-015021-pol2qm74	1917	15	treated	treat	VBN
cord-015021-pol2qm74	1917	16	HUVEC	HUVEC	NNP
cord-015021-pol2qm74	1917	17	could	could	MD
cord-015021-pol2qm74	1917	18	be	be	VB
cord-015021-pol2qm74	1917	19	downregulated	downregulate	VBN
cord-015021-pol2qm74	1917	20	by	by	IN
cord-015021-pol2qm74	1917	21	the	the	DT
cord-015021-pol2qm74	1917	22	PKC	PKC	NNP
cord-015021-pol2qm74	1917	23	-	-	HYPH
cord-015021-pol2qm74	1917	24	inhibitor	inhibitor	NN
cord-015021-pol2qm74	1917	25	,	,	,
cord-015021-pol2qm74	1917	26	whereas	whereas	IN
cord-015021-pol2qm74	1917	27	TNFc~-and	TNFc~-and	NNP
cord-015021-pol2qm74	1917	28	LPS	LPS	NNP
cord-015021-pol2qm74	1917	29	-	-	HYPH
cord-015021-pol2qm74	1917	30	mediated	mediate	VBN
cord-015021-pol2qm74	1917	31	adhesion	adhesion	NN
cord-015021-pol2qm74	1917	32	was	be	VBD
cord-015021-pol2qm74	1917	33	not	not	RB
cord-015021-pol2qm74	1917	34	influenced	influence	VBN
cord-015021-pol2qm74	1917	35	.	.	.
cord-015021-pol2qm74	1918	1	Additionally	additionally	RB
cord-015021-pol2qm74	1918	2	,	,	,
cord-015021-pol2qm74	1918	3	the	the	DT
cord-015021-pol2qm74	1918	4	IL-1	IL-1	NNP
cord-015021-pol2qm74	1918	5	driven	drive	VBD
cord-015021-pol2qm74	1918	6	ICAM-1	ICAM-1	JJR
cord-015021-pol2qm74	1918	7	expression	expression	NN
cord-015021-pol2qm74	1918	8	on	on	IN
cord-015021-pol2qm74	1918	9	EAhy926	EAhy926	NNP
cord-015021-pol2qm74	1918	10	cells	cell	NNS
cord-015021-pol2qm74	1918	11	as	as	RB
cord-015021-pol2qm74	1918	12	well	well	RB
cord-015021-pol2qm74	1918	13	as	as	IN
cord-015021-pol2qm74	1918	14	the	the	DT
cord-015021-pol2qm74	1918	15	IL-1	IL-1	NNP
cord-015021-pol2qm74	1918	16	induced	induce	VBD
cord-015021-pol2qm74	1918	17	adhesion	adhesion	NN
cord-015021-pol2qm74	1918	18	of	of	IN
cord-015021-pol2qm74	1918	19	PBMC	PBMC	NNS
cord-015021-pol2qm74	1918	20	to	to	IN
cord-015021-pol2qm74	1918	21	HUVEC	HUVEC	NNP
cord-015021-pol2qm74	1918	22	was	be	VBD
cord-015021-pol2qm74	1918	23	found	find	VBN
cord-015021-pol2qm74	1918	24	to	to	TO
cord-015021-pol2qm74	1918	25	be	be	VB
cord-015021-pol2qm74	1918	26	TNF	tnf	NN
cord-015021-pol2qm74	1918	27	-	-	HYPH
cord-015021-pol2qm74	1918	28	dependent	dependent	JJ
cord-015021-pol2qm74	1918	29	,	,	,
cord-015021-pol2qm74	1918	30	since	since	IN
cord-015021-pol2qm74	1918	31	both	both	DT
cord-015021-pol2qm74	1918	32	effects	effect	NNS
cord-015021-pol2qm74	1918	33	could	could	MD
cord-015021-pol2qm74	1918	34	be	be	VB
cord-015021-pol2qm74	1918	35	inhibited	inhibit	VBN
cord-015021-pol2qm74	1918	36	by	by	IN
cord-015021-pol2qm74	1918	37	an	an	DT
cord-015021-pol2qm74	1918	38	anti	anti	JJ
cord-015021-pol2qm74	1918	39	-	-	JJ
cord-015021-pol2qm74	1918	40	TNF	tnf	JJ
cord-015021-pol2qm74	1918	41	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	1918	42	antibody	antibody	NN
cord-015021-pol2qm74	1918	43	(	(	-LRB-
cord-015021-pol2qm74	1918	44	195F	195f	CD
cord-015021-pol2qm74	1918	45	)	)	-RRB-
cord-015021-pol2qm74	1918	46	.	.	.
cord-015021-pol2qm74	1919	1	These	these	DT
cord-015021-pol2qm74	1919	2	in	in	IN
cord-015021-pol2qm74	1919	3	vitro	vitro	FW
cord-015021-pol2qm74	1919	4	data	data	NN
cord-015021-pol2qm74	1919	5	further	far	RBR
cord-015021-pol2qm74	1919	6	support	support	VBP
cord-015021-pol2qm74	1919	7	the	the	DT
cord-015021-pol2qm74	1919	8	idea	idea	NN
cord-015021-pol2qm74	1919	9	of	of	IN
cord-015021-pol2qm74	1919	10	examining	examine	VBG
cord-015021-pol2qm74	1919	11	PKC	PKC	NNP
cord-015021-pol2qm74	1919	12	-	-	HYPH
cord-015021-pol2qm74	1919	13	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	1919	14	,	,	,
cord-015021-pol2qm74	1919	15	such	such	JJ
cord-015021-pol2qm74	1919	16	as	as	IN
cord-015021-pol2qm74	1919	17	GF109203X	GF109203X	NNP
cord-015021-pol2qm74	1919	18	,	,	,
cord-015021-pol2qm74	1919	19	for	for	IN
cord-015021-pol2qm74	1919	20	their	-PRON-	PRP$
cord-015021-pol2qm74	1919	21	biological	biological	JJ
cord-015021-pol2qm74	1919	22	relevance	relevance	NN
cord-015021-pol2qm74	1919	23	in	in	IN
cord-015021-pol2qm74	1919	24	cytokine	cytokine	JJ
cord-015021-pol2qm74	1919	25	related	related	JJ
cord-015021-pol2qm74	1919	26	dysregulations	dysregulation	NNS
cord-015021-pol2qm74	1919	27	.	.	.
cord-015021-pol2qm74	1920	1	Seiffge	Seiffge	NNP
cord-015021-pol2qm74	1920	2	,	,	,
cord-015021-pol2qm74	1920	3	D.	D.	NNP
cord-015021-pol2qm74	1920	4	,	,	,
cord-015021-pol2qm74	1920	5	Bissinger	Bissinger	NNP
cord-015021-pol2qm74	1920	6	,	,	,
cord-015021-pol2qm74	1920	7	T.	T.	NNP
cord-015021-pol2qm74	1920	8	,	,	,
cord-015021-pol2qm74	1920	9	Laux	Laux	NNP
cord-015021-pol2qm74	1920	10	,	,	,
cord-015021-pol2qm74	1920	11	V.	V.	NNP
cord-015021-pol2qm74	1920	12	,	,	,
cord-015021-pol2qm74	1920	13	During	during	IN
cord-015021-pol2qm74	1920	14	inflammation	inflammation	NN
cord-015021-pol2qm74	1920	15	there	there	EX
cord-015021-pol2qm74	1920	16	are	be	VBP
cord-015021-pol2qm74	1920	17	some	some	DT
cord-015021-pol2qm74	1920	18	key	key	JJ
cord-015021-pol2qm74	1920	19	processes	process	NNS
cord-015021-pol2qm74	1920	20	,	,	,
cord-015021-pol2qm74	1920	21	which	which	WDT
cord-015021-pol2qm74	1920	22	occur	occur	VBP
cord-015021-pol2qm74	1920	23	in	in	IN
cord-015021-pol2qm74	1920	24	the	the	DT
cord-015021-pol2qm74	1920	25	microcirculation	microcirculation	NN
cord-015021-pol2qm74	1920	26	:	:	:
cord-015021-pol2qm74	1921	1	The	the	DT
cord-015021-pol2qm74	1921	2	release	release	NN
cord-015021-pol2qm74	1921	3	of	of	IN
cord-015021-pol2qm74	1921	4	mediators	mediator	NNS
cord-015021-pol2qm74	1921	5	from	from	IN
cord-015021-pol2qm74	1921	6	various	various	JJ
cord-015021-pol2qm74	1921	7	cell	cell	NN
cord-015021-pol2qm74	1921	8	types	type	NNS
cord-015021-pol2qm74	1921	9	,	,	,
cord-015021-pol2qm74	1921	10	the	the	DT
cord-015021-pol2qm74	1921	11	migration	migration	NN
cord-015021-pol2qm74	1921	12	of	of	IN
cord-015021-pol2qm74	1921	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1921	14	cells	cell	NNS
cord-015021-pol2qm74	1921	15	towards	towards	IN
cord-015021-pol2qm74	1921	16	a	a	DT
cord-015021-pol2qm74	1921	17	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	1921	18	stimulus	stimulus	NN
cord-015021-pol2qm74	1921	19	in	in	IN
cord-015021-pol2qm74	1921	20	the	the	DT
cord-015021-pol2qm74	1921	21	tissue	tissue	NN
cord-015021-pol2qm74	1921	22	,	,	,
cord-015021-pol2qm74	1921	23	the	the	DT
cord-015021-pol2qm74	1921	24	expression	expression	NN
cord-015021-pol2qm74	1921	25	of	of	IN
cord-015021-pol2qm74	1921	26	adhesion	adhesion	NN
cord-015021-pol2qm74	1921	27	molecules	molecule	NNS
cord-015021-pol2qm74	1921	28	on	on	IN
cord-015021-pol2qm74	1921	29	different	different	JJ
cord-015021-pol2qm74	1921	30	cells	cell	NNS
cord-015021-pol2qm74	1921	31	,	,	,
cord-015021-pol2qm74	1921	32	and	and	CC
cord-015021-pol2qm74	1921	33	the	the	DT
cord-015021-pol2qm74	1921	34	extravasation	extravasation	NN
cord-015021-pol2qm74	1921	35	of	of	IN
cord-015021-pol2qm74	1921	36	plasma	plasma	NN
cord-015021-pol2qm74	1921	37	proteins	protein	NNS
cord-015021-pol2qm74	1921	38	.	.	.
cord-015021-pol2qm74	1922	1	The	the	DT
cord-015021-pol2qm74	1922	2	aim	aim	NN
cord-015021-pol2qm74	1922	3	of	of	IN
cord-015021-pol2qm74	1922	4	the	the	DT
cord-015021-pol2qm74	1922	5	present	present	JJ
cord-015021-pol2qm74	1922	6	study	study	NN
cord-015021-pol2qm74	1922	7	was	be	VBD
cord-015021-pol2qm74	1922	8	to	to	TO
cord-015021-pol2qm74	1922	9	elucidate	elucidate	VB
cord-015021-pol2qm74	1922	10	the	the	DT
cord-015021-pol2qm74	1922	11	mediator	mediator	NN
cord-015021-pol2qm74	1922	12	induced	induce	VBN
cord-015021-pol2qm74	1922	13	interaction	interaction	NN
cord-015021-pol2qm74	1922	14	of	of	IN
cord-015021-pol2qm74	1922	15	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1922	16	adhesion	adhesion	NN
cord-015021-pol2qm74	1922	17	and	and	CC
cord-015021-pol2qm74	1922	18	plasma	plasma	NN
cord-015021-pol2qm74	1922	19	leakage	leakage	NN
cord-015021-pol2qm74	1922	20	in	in	IN
cord-015021-pol2qm74	1922	21	postcapillary	postcapillary	NNP
cord-015021-pol2qm74	1922	22	venules	venule	NNS
cord-015021-pol2qm74	1922	23	.	.	.
cord-015021-pol2qm74	1923	1	Using	use	VBG
cord-015021-pol2qm74	1923	2	an	an	DT
cord-015021-pol2qm74	1923	3	analogous	analogous	JJ
cord-015021-pol2qm74	1923	4	video	video	NN
cord-015021-pol2qm74	1923	5	-	-	HYPH
cord-015021-pol2qm74	1923	6	image	image	NN
cord-015021-pol2qm74	1923	7	analysing	analysing	NN
cord-015021-pol2qm74	1923	8	system	system	NN
cord-015021-pol2qm74	1923	9	we	-PRON-	PRP
cord-015021-pol2qm74	1923	10	have	have	VBP
cord-015021-pol2qm74	1923	11	studied	study	VBN
cord-015021-pol2qm74	1923	12	the	the	DT
cord-015021-pol2qm74	1923	13	effect	effect	NN
cord-015021-pol2qm74	1923	14	of	of	IN
cord-015021-pol2qm74	1923	15	different	different	JJ
cord-015021-pol2qm74	1923	16	mediators	mediator	NNS
cord-015021-pol2qm74	1923	17	on	on	IN
cord-015021-pol2qm74	1923	18	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1923	19	adhesion	adhesion	NN
cord-015021-pol2qm74	1923	20	and	and	CC
cord-015021-pol2qm74	1923	21	macromolecular	macromolecular	JJ
cord-015021-pol2qm74	1923	22	permeability	permeability	NN
cord-015021-pol2qm74	1923	23	in	in	IN
cord-015021-pol2qm74	1923	24	the	the	DT
cord-015021-pol2qm74	1923	25	mesentery	mesentery	NN
cord-015021-pol2qm74	1923	26	of	of	IN
cord-015021-pol2qm74	1923	27	the	the	DT
cord-015021-pol2qm74	1923	28	rat	rat	NN
cord-015021-pol2qm74	1923	29	.	.	.
cord-015021-pol2qm74	1924	1	The	the	DT
cord-015021-pol2qm74	1924	2	increase	increase	NN
cord-015021-pol2qm74	1924	3	in	in	IN
cord-015021-pol2qm74	1924	4	permeability	permeability	NN
cord-015021-pol2qm74	1924	5	was	be	VBD
cord-015021-pol2qm74	1924	6	measured	measure	VBN
cord-015021-pol2qm74	1924	7	as	as	IN
cord-015021-pol2qm74	1924	8	changes	change	NNS
cord-015021-pol2qm74	1924	9	in	in	IN
cord-015021-pol2qm74	1924	10	optical	optical	JJ
cord-015021-pol2qm74	1924	11	density	density	NN
cord-015021-pol2qm74	1924	12	.	.	.
cord-015021-pol2qm74	1925	1	We	-PRON-	PRP
cord-015021-pol2qm74	1925	2	found	find	VBD
cord-015021-pol2qm74	1925	3	that	that	IN
cord-015021-pol2qm74	1925	4	topical	topical	JJ
cord-015021-pol2qm74	1925	5	administration	administration	NN
cord-015021-pol2qm74	1925	6	of	of	IN
cord-015021-pol2qm74	1925	7	leneotriene	leneotriene	NNP
cord-015021-pol2qm74	1925	8	B	B	NNP
cord-015021-pol2qm74	1925	9	4	4	CD
cord-015021-pol2qm74	1926	1	(	(	-LRB-
cord-015021-pol2qm74	1926	2	LTB4	LTB4	NNP
cord-015021-pol2qm74	1926	3	,	,	,
cord-015021-pol2qm74	1926	4	5x10	5x10	CD
cord-015021-pol2qm74	1926	5	"	"	``
cord-015021-pol2qm74	1926	6	6	6	CD
cord-015021-pol2qm74	1926	7	tool	tool	NN
cord-015021-pol2qm74	1926	8	/	/	SYM
cord-015021-pol2qm74	1926	9	l	l	NN
cord-015021-pol2qm74	1926	10	)	)	-RRB-
cord-015021-pol2qm74	1926	11	or	or	CC
cord-015021-pol2qm74	1926	12	intravenous	intravenous	JJ
cord-015021-pol2qm74	1926	13	injection	injection	NN
cord-015021-pol2qm74	1926	14	of	of	IN
cord-015021-pol2qm74	1926	15	interleuldn-2	interleuldn-2	NNP
cord-015021-pol2qm74	1927	1	(	(	-LRB-
cord-015021-pol2qm74	1927	2	IL-2	IL-2	NNP
cord-015021-pol2qm74	1927	3	,	,	,
cord-015021-pol2qm74	1927	4	5	5	CD
cord-015021-pol2qm74	1927	5	-	-	SYM
cord-015021-pol2qm74	1927	6	106	106	CD
cord-015021-pol2qm74	1927	7	IU	IU	NNP
cord-015021-pol2qm74	1927	8	/	/	SYM
cord-015021-pol2qm74	1927	9	kg	kg	NN
cord-015021-pol2qm74	1927	10	b.w	b.w	NNP
cord-015021-pol2qm74	1927	11	.	.	.
cord-015021-pol2qm74	1928	1	)	)	-RRB-
cord-015021-pol2qm74	1928	2	and	and	CC
cord-015021-pol2qm74	1928	3	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	1928	4	(	(	-LRB-
cord-015021-pol2qm74	1928	5	LPS	LPS	NNP
cord-015021-pol2qm74	1928	6	,	,	,
cord-015021-pol2qm74	1928	7	15	15	CD
cord-015021-pol2qm74	1928	8	mg	mg	NNP
cord-015021-pol2qm74	1928	9	/	/	SYM
cord-015021-pol2qm74	1928	10	kg	kg	NNP
cord-015021-pol2qm74	1928	11	b.w	b.w	NNP
cord-015021-pol2qm74	1928	12	.	.	NNP
cord-015021-pol2qm74	1928	13	)	)	-RRB-
cord-015021-pol2qm74	1928	14	resulted	result	VBD
cord-015021-pol2qm74	1928	15	in	in	IN
cord-015021-pol2qm74	1928	16	a	a	DT
cord-015021-pol2qm74	1928	17	significant	significant	JJ
cord-015021-pol2qm74	1928	18	extravasation	extravasation	NN
cord-015021-pol2qm74	1928	19	of	of	IN
cord-015021-pol2qm74	1928	20	FITC	FITC	NNP
cord-015021-pol2qm74	1928	21	-	-	HYPH
cord-015021-pol2qm74	1928	22	labelled	label	VBN
cord-015021-pol2qm74	1928	23	rat	rat	NN
cord-015021-pol2qm74	1928	24	serum	serum	NN
cord-015021-pol2qm74	1928	25	albumin	albumin	NN
cord-015021-pol2qm74	1928	26	(	(	-LRB-
cord-015021-pol2qm74	1928	27	FITC	FITC	NNP
cord-015021-pol2qm74	1928	28	-	-	HYPH
cord-015021-pol2qm74	1928	29	RSA	RSA	NNP
cord-015021-pol2qm74	1928	30	)	)	-RRB-
cord-015021-pol2qm74	1928	31	in	in	IN
cord-015021-pol2qm74	1928	32	venules	venule	NNS
cord-015021-pol2qm74	1928	33	but	but	CC
cord-015021-pol2qm74	1928	34	not	not	RB
cord-015021-pol2qm74	1928	35	in	in	IN
cord-015021-pol2qm74	1928	36	arterioles	arteriole	NNS
cord-015021-pol2qm74	1928	37	.	.	.
cord-015021-pol2qm74	1929	1	We	-PRON-	PRP
cord-015021-pol2qm74	1929	2	could	could	MD
cord-015021-pol2qm74	1929	3	correlate	correlate	VB
cord-015021-pol2qm74	1929	4	the	the	DT
cord-015021-pol2qm74	1929	5	changes	change	NNS
cord-015021-pol2qm74	1929	6	in	in	IN
cord-015021-pol2qm74	1929	7	vascular	vascular	JJ
cord-015021-pol2qm74	1929	8	permeability	permeability	NN
cord-015021-pol2qm74	1929	9	with	with	IN
cord-015021-pol2qm74	1929	10	a	a	DT
cord-015021-pol2qm74	1929	11	locally	locally	RB
cord-015021-pol2qm74	1929	12	increased	increase	VBN
cord-015021-pol2qm74	1929	13	number	number	NN
cord-015021-pol2qm74	1929	14	of	of	IN
cord-015021-pol2qm74	1929	15	rolling	roll	VBG
cord-015021-pol2qm74	1929	16	and	and	CC
cord-015021-pol2qm74	1929	17	sticking	stick	VBG
cord-015021-pol2qm74	1929	18	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1929	19	in	in	IN
cord-015021-pol2qm74	1929	20	venules	venule	NNS
cord-015021-pol2qm74	1929	21	.	.	.
cord-015021-pol2qm74	1930	1	Both	both	DT
cord-015021-pol2qm74	1930	2	effects	effect	NNS
cord-015021-pol2qm74	1930	3	were	be	VBD
cord-015021-pol2qm74	1930	4	dose	dose	VBN
cord-015021-pol2qm74	1930	5	dependently	dependently	RB
cord-015021-pol2qm74	1930	6	inhibited	inhibit	VBN
cord-015021-pol2qm74	1930	7	by	by	IN
cord-015021-pol2qm74	1930	8	different	different	JJ
cord-015021-pol2qm74	1930	9	drugs	drug	NNS
cord-015021-pol2qm74	1930	10	.	.	.
cord-015021-pol2qm74	1931	1	Pentoxlfylline	Pentoxlfylline	NNP
cord-015021-pol2qm74	1931	2	inhibits	inhibit	VBZ
cord-015021-pol2qm74	1931	3	LPS	LPS	NNP
cord-015021-pol2qm74	1931	4	-	-	HYPH
cord-015021-pol2qm74	1931	5	indueed	indueed	NN
cord-015021-pol2qm74	1931	6	FITC	FITC	NNP
cord-015021-pol2qm74	1931	7	-	-	HYPH
cord-015021-pol2qm74	1931	8	RSA	rsa	NN
cord-015021-pol2qm74	1931	9	extravasation	extravasation	NN
cord-015021-pol2qm74	1931	10	and	and	CC
cord-015021-pol2qm74	1931	11	leukocyte	leukocyte	NN
cord-015021-pol2qm74	1931	12	adhesion	adhesion	NN
cord-015021-pol2qm74	1931	13	at	at	IN
cord-015021-pol2qm74	1931	14	a	a	DT
cord-015021-pol2qm74	1931	15	dose	dose	NN
cord-015021-pol2qm74	1931	16	of	of	IN
cord-015021-pol2qm74	1931	17	3	3	CD
cord-015021-pol2qm74	1931	18	mg	mg	NNP
cord-015021-pol2qm74	1931	19	/	/	SYM
cord-015021-pol2qm74	1931	20	kg	kg	NNP
cord-015021-pol2qm74	1931	21	b.w	b.w	NNP
cord-015021-pol2qm74	1931	22	.	.	.
cord-015021-pol2qm74	1932	1	,	,	,
cord-015021-pol2qm74	1932	2	superoxid	superoxid	NN
cord-015021-pol2qm74	1932	3	-	-	HYPH
cord-015021-pol2qm74	1932	4	dismutase	dismutase	NN
cord-015021-pol2qm74	1932	5	(	(	-LRB-
cord-015021-pol2qm74	1932	6	SOD	SOD	NNP
cord-015021-pol2qm74	1932	7	,	,	,
cord-015021-pol2qm74	1932	8	10.000	10.000	CD
cord-015021-pol2qm74	1932	9	IU	IU	NNP
cord-015021-pol2qm74	1932	10	/	/	SYM
cord-015021-pol2qm74	1932	11	kg	kg	NN
cord-015021-pol2qm74	1932	12	b.w	b.w	NNP
cord-015021-pol2qm74	1932	13	.	.	NNP
cord-015021-pol2qm74	1932	14	)	)	-RRB-
cord-015021-pol2qm74	1932	15	was	be	VBD
cord-015021-pol2qm74	1932	16	able	able	JJ
cord-015021-pol2qm74	1932	17	to	to	TO
cord-015021-pol2qm74	1932	18	decrease	decrease	VB
cord-015021-pol2qm74	1932	19	the	the	DT
cord-015021-pol2qm74	1932	20	LTB	LTB	NNP
cord-015021-pol2qm74	1932	21	4	4	CD
cord-015021-pol2qm74	1932	22	effect	effect	NN
cord-015021-pol2qm74	1932	23	,	,	,
cord-015021-pol2qm74	1932	24	and	and	CC
cord-015021-pol2qm74	1932	25	the	the	DT
cord-015021-pol2qm74	1932	26	immuumodulating	immuumodulate	VBG
cord-015021-pol2qm74	1932	27	drug	drug	NNP
cord-015021-pol2qm74	1932	28	leflunomide	leflunomide	NNP
cord-015021-pol2qm74	1932	29	(	(	-LRB-
cord-015021-pol2qm74	1932	30	HWA	HWA	NNP
cord-015021-pol2qm74	1932	31	486	486	CD
cord-015021-pol2qm74	1932	32	)	)	-RRB-
cord-015021-pol2qm74	1932	33	exerted	exert	VBD
cord-015021-pol2qm74	1932	34	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	1932	35	effects	effect	NNS
cord-015021-pol2qm74	1932	36	on	on	IN
cord-015021-pol2qm74	1932	37	IL-2-induced	il-2-induced	CD
cord-015021-pol2qm74	1932	38	permeability	permeability	NN
cord-015021-pol2qm74	1932	39	at	at	IN
cord-015021-pol2qm74	1932	40	a	a	DT
cord-015021-pol2qm74	1932	41	dose	dose	NN
cord-015021-pol2qm74	1932	42	of	of	IN
cord-015021-pol2qm74	1932	43	3	3	CD
cord-015021-pol2qm74	1932	44	mg	mg	NNP
cord-015021-pol2qm74	1932	45	/	/	SYM
cord-015021-pol2qm74	1932	46	kg	kg	NNP
cord-015021-pol2qm74	1932	47	b.w.i.v	b.w.i.v	NNP
cord-015021-pol2qm74	1932	48	.	.	.
cord-015021-pol2qm74	1933	1	The	the	DT
cord-015021-pol2qm74	1933	2	obtained	obtain	VBN
cord-015021-pol2qm74	1933	3	results	result	NNS
cord-015021-pol2qm74	1933	4	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	1933	5	that	that	IN
cord-015021-pol2qm74	1933	6	LPS	LPS	NNP
cord-015021-pol2qm74	1933	7	,	,	,
cord-015021-pol2qm74	1933	8	LTB	LTB	NNP
cord-015021-pol2qm74	1933	9	4	4	CD
cord-015021-pol2qm74	1933	10	or	or	CC
cord-015021-pol2qm74	1933	11	IL-2	IL-2	NNP
cord-015021-pol2qm74	1933	12	induced	induce	VBD
cord-015021-pol2qm74	1933	13	extravasation	extravasation	NN
cord-015021-pol2qm74	1933	14	of	of	IN
cord-015021-pol2qm74	1933	15	FITC	FITC	NNP
cord-015021-pol2qm74	1933	16	-	-	HYPH
cord-015021-pol2qm74	1933	17	RSA	RSA	NNP
cord-015021-pol2qm74	1933	18	is	be	VBZ
cord-015021-pol2qm74	1933	19	mediated	mediate	VBN
cord-015021-pol2qm74	1933	20	by	by	IN
cord-015021-pol2qm74	1933	21	activated	activate	VBN
cord-015021-pol2qm74	1933	22	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	1933	23	and	and	CC
cord-015021-pol2qm74	1933	24	can	can	MD
cord-015021-pol2qm74	1933	25	be	be	VB
cord-015021-pol2qm74	1933	26	deminished	deminishe	VBN
cord-015021-pol2qm74	1933	27	following	follow	VBG
cord-015021-pol2qm74	1933	28	administration	administration	NN
cord-015021-pol2qm74	1933	29	of	of	IN
cord-015021-pol2qm74	1933	30	different	different	JJ
cord-015021-pol2qm74	1933	31	drugs	drug	NNS
cord-015021-pol2qm74	1933	32	.	.	.
cord-015021-pol2qm74	1934	1	Platelet	platelet	NN
cord-015021-pol2qm74	1934	2	-	-	HYPH
cord-015021-pol2qm74	1934	3	endothelial	endothelial	JJ
cord-015021-pol2qm74	1934	4	cell	cell	NN
cord-015021-pol2qm74	1934	5	adhesion	adhesion	NN
cord-015021-pol2qm74	1934	6	molecule-	molecule-	NN
cord-015021-pol2qm74	1935	1	i	i	PRP
cord-015021-pol2qm74	1935	2	(	(	-LRB-
cord-015021-pol2qm74	1935	3	PECAM	PECAM	NNP
cord-015021-pol2qm74	1935	4	-	-	HYPH
cord-015021-pol2qm74	1935	5	I	I	NNP
cord-015021-pol2qm74	1935	6	)	)	-RRB-
cord-015021-pol2qm74	1935	7	,	,	,
cord-015021-pol2qm74	1935	8	a	a	DT
cord-015021-pol2qm74	1935	9	member	member	NN
cord-015021-pol2qm74	1935	10	of	of	IN
cord-015021-pol2qm74	1935	11	the	the	DT
cord-015021-pol2qm74	1935	12	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	1935	13	superfamily	superfamily	NN
cord-015021-pol2qm74	1935	14	,	,	,
cord-015021-pol2qm74	1935	15	is	be	VBZ
cord-015021-pol2qm74	1935	16	constitutively	constitutively	RB
cord-015021-pol2qm74	1935	17	expressed	express	VBN
cord-015021-pol2qm74	1935	18	at	at	IN
cord-015021-pol2qm74	1935	19	high	high	JJ
cord-015021-pol2qm74	1935	20	levels	level	NNS
cord-015021-pol2qm74	1935	21	on	on	IN
cord-015021-pol2qm74	1935	22	the	the	DT
cord-015021-pol2qm74	1935	23	endothelial	endothelial	JJ
cord-015021-pol2qm74	1935	24	cell	cell	NN
cord-015021-pol2qm74	1935	25	surface	surface	NN
cord-015021-pol2qm74	1935	26	.	.	.
cord-015021-pol2qm74	1936	1	In	in	IN
cord-015021-pol2qm74	1936	2	vitro	vitro	FW
cord-015021-pol2qm74	1936	3	data	datum	NNS
cord-015021-pol2qm74	1936	4	have	have	VBP
cord-015021-pol2qm74	1936	5	suggested	suggest	VBN
cord-015021-pol2qm74	1936	6	that	that	IN
cord-015021-pol2qm74	1936	7	PECAM	PECAM	NNP
cord-015021-pol2qm74	1936	8	-	-	HYPH
cord-015021-pol2qm74	1936	9	I	-PRON-	PRP
cord-015021-pol2qm74	1936	10	functions	function	VBZ
cord-015021-pol2qm74	1936	11	as	as	IN
cord-015021-pol2qm74	1936	12	a	a	DT
cord-015021-pol2qm74	1936	13	vascular	vascular	JJ
cord-015021-pol2qm74	1936	14	adhesion	adhesion	NN
cord-015021-pol2qm74	1936	15	molecule	molecule	NN
cord-015021-pol2qm74	1936	16	,	,	,
cord-015021-pol2qm74	1936	17	specifically	specifically	RB
cord-015021-pol2qm74	1936	18	in	in	IN
cord-015021-pol2qm74	1936	19	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1936	20	transmigration	transmigration	NN
cord-015021-pol2qm74	1936	21	across	across	IN
cord-015021-pol2qm74	1936	22	the	the	DT
cord-015021-pol2qm74	1936	23	endothelium	endothelium	NN
cord-015021-pol2qm74	1936	24	.	.	.
cord-015021-pol2qm74	1937	1	This	this	DT
cord-015021-pol2qm74	1937	2	current	current	JJ
cord-015021-pol2qm74	1937	3	work	work	NN
cord-015021-pol2qm74	1937	4	is	be	VBZ
cord-015021-pol2qm74	1937	5	the	the	DT
cord-015021-pol2qm74	1937	6	first	first	RB
cord-015021-pol2qm74	1937	7	demonstrating	demonstrate	VBG
cord-015021-pol2qm74	1937	8	the	the	DT
cord-015021-pol2qm74	1937	9	in	in	IN
cord-015021-pol2qm74	1937	10	vivo	vivo	NN
cord-015021-pol2qm74	1937	11	role	role	NN
cord-015021-pol2qm74	1937	12	of	of	IN
cord-015021-pol2qm74	1937	13	PECAM-1	PECAM-1	NNP
cord-015021-pol2qm74	1937	14	in	in	IN
cord-015021-pol2qm74	1937	15	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1937	16	migration	migration	NN
cord-015021-pol2qm74	1937	17	.	.	.
cord-015021-pol2qm74	1938	1	Blocking	block	VBG
cord-015021-pol2qm74	1938	2	antibodies	antibody	NNS
cord-015021-pol2qm74	1938	3	to	to	IN
cord-015021-pol2qm74	1938	4	human	human	JJ
cord-015021-pol2qm74	1938	5	PECAM-1	PECAM-1	NNP
cord-015021-pol2qm74	1938	6	,	,	,
cord-015021-pol2qm74	1938	7	in	in	IN
cord-015021-pol2qm74	1938	8	which	which	WDT
cord-015021-pol2qm74	1938	9	the	the	DT
cord-015021-pol2qm74	1938	10	antibodies	antibody	NNS
cord-015021-pol2qm74	1938	11	are	be	VBP
cord-015021-pol2qm74	1938	12	crossreactive	crossreactive	JJ
cord-015021-pol2qm74	1938	13	with	with	IN
cord-015021-pol2qm74	1938	14	rat	rat	NN
cord-015021-pol2qm74	1938	15	PECAM-1	PECAM-1	NNP
cord-015021-pol2qm74	1938	16	,	,	,
cord-015021-pol2qm74	1938	17	were	be	VBD
cord-015021-pol2qm74	1938	18	able	able	JJ
cord-015021-pol2qm74	1938	19	to	to	TO
cord-015021-pol2qm74	1938	20	block	block	VB
cord-015021-pol2qm74	1938	21	the	the	DT
cord-015021-pol2qm74	1938	22	movement	movement	NN
cord-015021-pol2qm74	1938	23	of	of	IN
cord-015021-pol2qm74	1938	24	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1938	25	into	into	IN
cord-015021-pol2qm74	1938	26	the	the	DT
cord-015021-pol2qm74	1938	27	rat	rat	NN
cord-015021-pol2qm74	1938	28	lungs	lung	NNS
cord-015021-pol2qm74	1938	29	after	after	IN
cord-015021-pol2qm74	1938	30	IgG	IgG	NNP
cord-015021-pol2qm74	1938	31	immune	immune	VBP
cord-015021-pol2qm74	1938	32	complex	complex	JJ
cord-015021-pol2qm74	1938	33	deposition	deposition	NN
cord-015021-pol2qm74	1938	34	.	.	.
cord-015021-pol2qm74	1939	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	1939	2	,	,	,
cord-015021-pol2qm74	1939	3	when	when	WRB
cord-015021-pol2qm74	1939	4	human	human	JJ
cord-015021-pol2qm74	1939	5	foreskin	foreskin	NN
cord-015021-pol2qm74	1939	6	was	be	VBD
cord-015021-pol2qm74	1939	7	transplanted	transplant	VBN
cord-015021-pol2qm74	1939	8	into	into	IN
cord-015021-pol2qm74	1939	9	mice	mouse	NNS
cord-015021-pol2qm74	1939	10	with	with	IN
cord-015021-pol2qm74	1939	11	severe	severe	JJ
cord-015021-pol2qm74	1939	12	combined	combine	VBN
cord-015021-pol2qm74	1939	13	immunodeficiency	immunodeficiency	NN
cord-015021-pol2qm74	1939	14	and	and	CC
cord-015021-pol2qm74	1939	15	the	the	DT
cord-015021-pol2qm74	1939	16	site	site	NN
cord-015021-pol2qm74	1939	17	injected	inject	VBN
cord-015021-pol2qm74	1939	18	with	with	IN
cord-015021-pol2qm74	1939	19	TNF	TNF	NNP
cord-015021-pol2qm74	1939	20	-	-	HYPH
cord-015021-pol2qm74	1939	21	alpha	alpha	NNP
cord-015021-pol2qm74	1939	22	,	,	,
cord-015021-pol2qm74	1939	23	anti	anti	JJ
cord-015021-pol2qm74	1939	24	-	-	JJ
cord-015021-pol2qm74	1939	25	PECAM	PECAM	NNP
cord-015021-pol2qm74	1939	26	-	-	HYPH
cord-015021-pol2qm74	1939	27	I	-PRON-	PRP
cord-015021-pol2qm74	1939	28	blocked	block	VBD
cord-015021-pol2qm74	1939	29	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1939	30	emigration	emigration	NN
cord-015021-pol2qm74	1939	31	into	into	IN
cord-015021-pol2qm74	1939	32	the	the	DT
cord-015021-pol2qm74	1939	33	dermal	dermal	JJ
cord-015021-pol2qm74	1939	34	interstitium	interstitium	NN
cord-015021-pol2qm74	1939	35	.	.	.
cord-015021-pol2qm74	1940	1	It	-PRON-	PRP
cord-015021-pol2qm74	1940	2	has	have	VBZ
cord-015021-pol2qm74	1940	3	already	already	RB
cord-015021-pol2qm74	1940	4	been	be	VBN
cord-015021-pol2qm74	1940	5	established	establish	VBN
cord-015021-pol2qm74	1940	6	that	that	IN
cord-015021-pol2qm74	1940	7	neutrophil	neutrophil	NN
cord-015021-pol2qm74	1940	8	recruitment	recruitment	NN
cord-015021-pol2qm74	1940	9	is	be	VBZ
cord-015021-pol2qm74	1940	10	dependent	dependent	JJ
cord-015021-pol2qm74	1940	11	upon	upon	IN
cord-015021-pol2qm74	1940	12	selectin	selectin	NNP
cord-015021-pol2qm74	1940	13	mediated	mediate	VBN
cord-015021-pol2qm74	1940	14	rolling	rolling	NN
cord-015021-pol2qm74	1940	15	,	,	,
cord-015021-pol2qm74	1940	16	followed	follow	VBN
cord-015021-pol2qm74	1940	17	by	by	IN
cord-015021-pol2qm74	1940	18	firm	firm	JJ
cord-015021-pol2qm74	1940	19	adherence	adherence	NN
cord-015021-pol2qm74	1940	20	that	that	WDT
cord-015021-pol2qm74	1940	21	is	be	VBZ
cord-015021-pol2qm74	1940	22	ICAM-1/	ICAM-1/	NNP
cord-015021-pol2qm74	1940	23	integrin	integrin	NN
cord-015021-pol2qm74	1940	24	mediated	mediate	VBN
cord-015021-pol2qm74	1940	25	.	.	.
cord-015021-pol2qm74	1941	1	These	these	DT
cord-015021-pol2qm74	1941	2	data	datum	NNS
cord-015021-pol2qm74	1941	3	suggest	suggest	VBP
cord-015021-pol2qm74	1941	4	,	,	,
cord-015021-pol2qm74	1941	5	for	for	IN
cord-015021-pol2qm74	1941	6	the	the	DT
cord-015021-pol2qm74	1941	7	first	first	JJ
cord-015021-pol2qm74	1941	8	time	time	NN
cord-015021-pol2qm74	1941	9	,	,	,
cord-015021-pol2qm74	1941	10	that	that	IN
cord-015021-pol2qm74	1941	11	a	a	DT
cord-015021-pol2qm74	1941	12	third	third	JJ
cord-015021-pol2qm74	1941	13	endothelial	endothelial	JJ
cord-015021-pol2qm74	1941	14	adhesion	adhesion	NN
cord-015021-pol2qm74	1941	15	molecule	molecule	NN
cord-015021-pol2qm74	1941	16	(	(	-LRB-
cord-015021-pol2qm74	1941	17	PECAM	PECAM	NNP
cord-015021-pol2qm74	1941	18	-	-	HYPH
cord-015021-pol2qm74	1941	19	I	I	NNP
cord-015021-pol2qm74	1941	20	)	)	-RRB-
cord-015021-pol2qm74	1941	21	is	be	VBZ
cord-015021-pol2qm74	1941	22	involved	involve	VBN
cord-015021-pol2qm74	1941	23	in	in	IN
cord-015021-pol2qm74	1941	24	the	the	DT
cord-015021-pol2qm74	1941	25	coordinated	coordinated	JJ
cord-015021-pol2qm74	1941	26	recruitment	recruitment	NN
cord-015021-pol2qm74	1941	27	of	of	IN
cord-015021-pol2qm74	1941	28	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	1941	29	in	in	IN
cord-015021-pol2qm74	1941	30	vivo	vivo	NNP
cord-015021-pol2qm74	1941	31	.	.	.
cord-015021-pol2qm74	1942	1	To	to	TO
cord-015021-pol2qm74	1942	2	test	test	VB
cord-015021-pol2qm74	1942	3	whether	whether	IN
cord-015021-pol2qm74	1942	4	trauma	trauma	NN
cord-015021-pol2qm74	1942	5	causes	cause	NNS
cord-015021-pol2qm74	1942	6	generalized	generalized	JJ
cord-015021-pol2qm74	1942	7	activation	activation	NN
cord-015021-pol2qm74	1942	8	or	or	CC
cord-015021-pol2qm74	1942	9	priming	priming	NN
cord-015021-pol2qm74	1942	10	of	of	IN
cord-015021-pol2qm74	1942	11	PMNs	pmn	NNS
cord-015021-pol2qm74	1942	12	,	,	,
cord-015021-pol2qm74	1942	13	CDI8	CDI8	NNP
cord-015021-pol2qm74	1942	14	adherence	adherence	NN
cord-015021-pol2qm74	1942	15	receptors	receptor	NNS
cord-015021-pol2qm74	1942	16	were	be	VBD
cord-015021-pol2qm74	1942	17	measured	measure	VBN
cord-015021-pol2qm74	1942	18	with	with	IN
cord-015021-pol2qm74	1942	19	iinmunomonitoring	iinmunomonitore	VBG
cord-015021-pol2qm74	1942	20	in	in	IN
cord-015021-pol2qm74	1942	21	whole	whole	JJ
cord-015021-pol2qm74	1942	22	blood	blood	NN
cord-015021-pol2qm74	1942	23	after	after	IN
cord-015021-pol2qm74	1942	24	LPS	LPS	NNP
cord-015021-pol2qm74	1942	25	stimulation	stimulation	NN
cord-015021-pol2qm74	1942	26	ex	ex	NN
cord-015021-pol2qm74	1942	27	vivo	vivo	NN
cord-015021-pol2qm74	1942	28	.	.	.
cord-015021-pol2qm74	1943	1	Anesthetized	anesthetized	JJ
cord-015021-pol2qm74	1943	2	(	(	-LRB-
cord-015021-pol2qm74	1943	3	Fentanyl	fentanyl	NN
cord-015021-pol2qm74	1943	4	)	)	-RRB-
cord-015021-pol2qm74	1943	5	mongrel	mongrel	JJ
cord-015021-pol2qm74	1943	6	pigs	pig	NNS
cord-015021-pol2qm74	1943	7	(	(	-LRB-
cord-015021-pol2qm74	1943	8	15	15	CD
cord-015021-pol2qm74	1943	9	-	-	SYM
cord-015021-pol2qm74	1943	10	25	25	CD
cord-015021-pol2qm74	1943	11	kg	kg	NNS
cord-015021-pol2qm74	1943	12	)	)	-RRB-
cord-015021-pol2qm74	1943	13	were	be	VBD
cord-015021-pol2qm74	1943	14	subjected	subject	VBN
cord-015021-pol2qm74	1943	15	to	to	IN
cord-015021-pol2qm74	1943	16	40	40	CD
cord-015021-pol2qm74	1943	17	%	%	NN
cord-015021-pol2qm74	1943	18	arterial	arterial	JJ
cord-015021-pol2qm74	1943	19	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	1943	20	+	+	CC
cord-015021-pol2qm74	1943	21	soft	soft	JJ
cord-015021-pol2qm74	1943	22	tissue	tissue	NN
cord-015021-pol2qm74	1943	23	injury	injury	NN
cord-015021-pol2qm74	1943	24	and	and	CC
cord-015021-pol2qm74	1943	25	after	after	IN
cord-015021-pol2qm74	1943	26	liar	liar	NN
cord-015021-pol2qm74	1943	27	,	,	,
cord-015021-pol2qm74	1943	28	resuscitated	resuscitate	VBD
cord-015021-pol2qm74	1943	29	with	with	IN
cord-015021-pol2qm74	1943	30	all	all	PDT
cord-015021-pol2qm74	1943	31	the	the	DT
cord-015021-pol2qm74	1943	32	shed	shed	JJ
cord-015021-pol2qm74	1943	33	blood	blood	NN
cord-015021-pol2qm74	1943	34	+	+	CC
cord-015021-pol2qm74	1943	35	supplemental	supplemental	JJ
cord-015021-pol2qm74	1943	36	fluid	fluid	NN
cord-015021-pol2qm74	1943	37	.	.	.
cord-015021-pol2qm74	1944	1	Blood	blood	NN
cord-015021-pol2qm74	1944	2	was	be	VBD
cord-015021-pol2qm74	1944	3	collected	collect	VBN
cord-015021-pol2qm74	1944	4	at	at	IN
cord-015021-pol2qm74	1944	5	24hr	24hr	JJ
cord-015021-pol2qm74	1944	6	intervals	interval	NNS
cord-015021-pol2qm74	1944	7	from	from	IN
cord-015021-pol2qm74	1944	8	unanesthetized	unanesthetized	JJ
cord-015021-pol2qm74	1944	9	animals	animal	NNS
cord-015021-pol2qm74	1944	10	with	with	IN
cord-015021-pol2qm74	1944	11	indwelling	indwell	VBG
cord-015021-pol2qm74	1944	12	catheters	catheter	NNS
cord-015021-pol2qm74	1944	13	,	,	,
cord-015021-pol2qm74	1944	14	PMNs	pmn	NNS
cord-015021-pol2qm74	1944	15	were	be	VBD
cord-015021-pol2qm74	1944	16	counted	count	VBN
cord-015021-pol2qm74	1944	17	,	,	,
cord-015021-pol2qm74	1944	18	and	and	CC
cord-015021-pol2qm74	1944	19	LPS	LPS	NNP
cord-015021-pol2qm74	1944	20	was	be	VBD
cord-015021-pol2qm74	1944	21	added	add	VBN
cord-015021-pol2qm74	1944	22	(	(	-LRB-
cord-015021-pol2qm74	1944	23	0,1,5,10	0,1,5,10	JJ
cord-015021-pol2qm74	1944	24	I.tg/ml	i.tg/ml	CD
cord-015021-pol2qm74	1944	25	)	)	-RRB-
cord-015021-pol2qm74	1944	26	ex	ex	NN
cord-015021-pol2qm74	1944	27	vivo	vivo	NN
cord-015021-pol2qm74	1944	28	.	.	.
cord-015021-pol2qm74	1945	1	After	after	IN
cord-015021-pol2qm74	1945	2	3hr	3hr	JJ
cord-015021-pol2qm74	1945	3	incubation	incubation	NN
cord-015021-pol2qm74	1945	4	at	at	IN
cord-015021-pol2qm74	1945	5	22	22	CD
cord-015021-pol2qm74	1945	6	-	-	SYM
cord-015021-pol2qm74	1945	7	24	24	CD
cord-015021-pol2qm74	1945	8	°	°	NN
cord-015021-pol2qm74	1945	9	C	c	NN
cord-015021-pol2qm74	1945	10	,	,	,
cord-015021-pol2qm74	1945	11	%	%	NN
cord-015021-pol2qm74	1945	12	CD18	CD18	NNP
cord-015021-pol2qm74	1945	13	(	(	-LRB-
cord-015021-pol2qm74	1945	14	+	+	NNS
cord-015021-pol2qm74	1945	15	)	)	-RRB-
cord-015021-pol2qm74	1945	16	PMNs	pmn	NNS
cord-015021-pol2qm74	1945	17	were	be	VBD
cord-015021-pol2qm74	1945	18	determined	determine	VBN
cord-015021-pol2qm74	1945	19	with	with	IN
cord-015021-pol2qm74	1945	20	FITC	FITC	NNP
cord-015021-pol2qm74	1945	21	-	-	HYPH
cord-015021-pol2qm74	1945	22	IB4	ib4	NN
cord-015021-pol2qm74	1945	23	and	and	CC
cord-015021-pol2qm74	1945	24	flow	flow	VB
cord-015021-pol2qm74	1945	25	cytometry	cytometry	NN
cord-015021-pol2qm74	1945	26	from	from	IN
cord-015021-pol2qm74	1945	27	mean	mean	JJ
cord-015021-pol2qm74	1945	28	channel	channel	NN
cord-015021-pol2qm74	1945	29	fluorescence	fluorescence	NN
cord-015021-pol2qm74	1945	30	histograms	histogram	NNS
cord-015021-pol2qm74	1945	31	.	.	.
cord-015021-pol2qm74	1946	1	49±8	49±8	CD
cord-015021-pol2qm74	1946	2	#	#	$
cord-015021-pol2qm74	1946	3	p<0.05	p<0.05	NN
cord-015021-pol2qm74	1946	4	vs	vs	IN
cord-015021-pol2qm74	1946	5	BASELINE	BASELINE	NNS
cord-015021-pol2qm74	1947	1	*	*	NFP
cord-015021-pol2qm74	1947	2	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	1947	3	vs	vs	IN
cord-015021-pol2qm74	1947	4	sham	sham	JJ
cord-015021-pol2qm74	1947	5	$	$	$
cord-015021-pol2qm74	1947	6	p<0.05	p<0.05	CD
cord-015021-pol2qm74	1948	1	vs	vs	IN
cord-015021-pol2qm74	1948	2	no	no	DT
cord-015021-pol2qm74	1948	3	anesthesia	anesthesia	NN
cord-015021-pol2qm74	1948	4	These	these	DT
cord-015021-pol2qm74	1948	5	observations	observation	NNS
cord-015021-pol2qm74	1948	6	provide	provide	VBP
cord-015021-pol2qm74	1948	7	direct	direct	JJ
cord-015021-pol2qm74	1948	8	evidence	evidence	NN
cord-015021-pol2qm74	1948	9	for	for	IN
cord-015021-pol2qm74	1948	10	time	time	NN
cord-015021-pol2qm74	1948	11	-	-	HYPH
cord-015021-pol2qm74	1948	12	dependent	dependent	JJ
cord-015021-pol2qm74	1948	13	changes	change	NNS
cord-015021-pol2qm74	1948	14	in	in	IN
cord-015021-pol2qm74	1948	15	PMN	pmn	NN
cord-015021-pol2qm74	1948	16	priming	prime	VBG
cord-015021-pol2qm74	1948	17	following	follow	VBG
cord-015021-pol2qm74	1948	18	major	major	JJ
cord-015021-pol2qm74	1948	19	injury	injury	NN
cord-015021-pol2qm74	1948	20	because	because	IN
cord-015021-pol2qm74	1948	21	CD18	CD18	NNP
cord-015021-pol2qm74	1948	22	expression	expression	NN
cord-015021-pol2qm74	1948	23	was	be	VBD
cord-015021-pol2qm74	1948	24	depressed	depressed	JJ
cord-015021-pol2qm74	1948	25	for	for	IN
cord-015021-pol2qm74	1948	26	at	at	IN
cord-015021-pol2qm74	1948	27	]	]	-RRB-
cord-015021-pol2qm74	1949	1	east	east	NNP
cord-015021-pol2qm74	1949	2	24hr	24hr	NNP
cord-015021-pol2qm74	1949	3	after	after	IN
cord-015021-pol2qm74	1949	4	trauma	trauma	NN
cord-015021-pol2qm74	1950	1	relative	relative	JJ
cord-015021-pol2qm74	1950	2	to	to	IN
cord-015021-pol2qm74	1950	3	sham	sham	NN
cord-015021-pol2qm74	1950	4	but	but	CC
cord-015021-pol2qm74	1950	5	by	by	IN
cord-015021-pol2qm74	1950	6	72hr	72hr	NNP
cord-015021-pol2qm74	1950	7	,	,	,
cord-015021-pol2qm74	1950	8	was	be	VBD
cord-015021-pol2qm74	1950	9	enhanced	enhance	VBN
cord-015021-pol2qm74	1950	10	,	,	,
cord-015021-pol2qm74	1950	11	relative	relative	JJ
cord-015021-pol2qm74	1950	12	to	to	IN
cord-015021-pol2qm74	1950	13	sham	sham	NN
cord-015021-pol2qm74	1950	14	,	,	,
cord-015021-pol2qm74	1950	15	and	and	CC
cord-015021-pol2qm74	1950	16	because	because	IN
cord-015021-pol2qm74	1950	17	fentanyl	fentanyl	NN
cord-015021-pol2qm74	1950	18	anesthesia	anesthesia	NN
cord-015021-pol2qm74	1950	19	at	at	IN
cord-015021-pol2qm74	1950	20	72hr	72hr	NNP
cord-015021-pol2qm74	1950	21	had	have	VBD
cord-015021-pol2qm74	1950	22	a	a	DT
cord-015021-pol2qm74	1950	23	greater	great	JJR
cord-015021-pol2qm74	1950	24	effect	effect	NN
cord-015021-pol2qm74	1950	25	on	on	IN
cord-015021-pol2qm74	1950	26	CD18	CD18	NNP
cord-015021-pol2qm74	1950	27	expression	expression	NN
cord-015021-pol2qm74	1950	28	in	in	IN
cord-015021-pol2qm74	1950	29	trauma	trauma	NN
cord-015021-pol2qm74	1950	30	vs	vs	IN
cord-015021-pol2qm74	1950	31	sham	sham	NN
cord-015021-pol2qm74	1950	32	.	.	.
cord-015021-pol2qm74	1951	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	1951	2	(	(	-LRB-
cord-015021-pol2qm74	1951	3	PMN	pmn	NN
cord-015021-pol2qm74	1951	4	)	)	-RRB-
cord-015021-pol2qm74	1951	5	adhesion	adhesion	NN
cord-015021-pol2qm74	1951	6	to	to	IN
cord-015021-pol2qm74	1951	7	vascular	vascular	JJ
cord-015021-pol2qm74	1951	8	endothelial	endothelial	JJ
cord-015021-pol2qm74	1951	9	cells	cell	NNS
cord-015021-pol2qm74	1951	10	(	(	-LRB-
cord-015021-pol2qm74	1951	11	•C	•c	NN
cord-015021-pol2qm74	1951	12	)	)	-RRB-
cord-015021-pol2qm74	1951	13	is	be	VBZ
cord-015021-pol2qm74	1951	14	a	a	DT
cord-015021-pol2qm74	1951	15	key	key	JJ
cord-015021-pol2qm74	1951	16	element	element	NN
cord-015021-pol2qm74	1951	17	in	in	IN
cord-015021-pol2qm74	1951	18	the	the	DT
cord-015021-pol2qm74	1951	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1951	20	response	response	NN
cord-015021-pol2qm74	1951	21	and	and	CC
cord-015021-pol2qm74	1951	22	tissue	tissue	NN
cord-015021-pol2qm74	1951	23	injury	injury	NN
cord-015021-pol2qm74	1951	24	.	.	.
cord-015021-pol2qm74	1952	1	Inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1952	2	mediators	mediator	NNS
cord-015021-pol2qm74	1952	3	such	such	JJ
cord-015021-pol2qm74	1952	4	as	as	IN
cord-015021-pol2qm74	1952	5	LPS	LPS	NNP
cord-015021-pol2qm74	1952	6	(	(	-LRB-
cord-015021-pol2qm74	1952	7	exogenous	exogenous	JJ
cord-015021-pol2qm74	1952	8	)	)	-RRB-
cord-015021-pol2qm74	1952	9	and	and	CC
cord-015021-pol2qm74	1952	10	TNF	TNF	NNP
cord-015021-pol2qm74	1952	11	(	(	-LRB-
cord-015021-pol2qm74	1952	12	endogenous	endogenous	JJ
cord-015021-pol2qm74	1952	13	)	)	-RRB-
cord-015021-pol2qm74	1952	14	can	can	MD
cord-015021-pol2qm74	1952	15	promote	promote	VB
cord-015021-pol2qm74	1952	16	PMN	PMN	NNP
cord-015021-pol2qm74	1952	17	-	-	HYPH
cord-015021-pol2qm74	1952	18	EC	EC	NNP
cord-015021-pol2qm74	1952	19	interaction	interaction	NN
cord-015021-pol2qm74	1952	20	which	which	WDT
cord-015021-pol2qm74	1952	21	is	be	VBZ
cord-015021-pol2qm74	1952	22	believed	believe	VBN
cord-015021-pol2qm74	1952	23	to	to	TO
cord-015021-pol2qm74	1952	24	be	be	VB
cord-015021-pol2qm74	1952	25	responsible	responsible	JJ
cord-015021-pol2qm74	1952	26	for	for	IN
cord-015021-pol2qm74	1952	27	capillary	capillary	JJ
cord-015021-pol2qm74	1952	28	leakage	leakage	NN
cord-015021-pol2qm74	1952	29	and	and	CC
cord-015021-pol2qm74	1952	30	subsequent	subsequent	JJ
cord-015021-pol2qm74	1952	31	organ	organ	NN
cord-015021-pol2qm74	1952	32	injury	injury	NN
cord-015021-pol2qm74	1952	33	.	.	.
cord-015021-pol2qm74	1953	1	However	however	RB
cord-015021-pol2qm74	1953	2	,	,	,
cord-015021-pol2qm74	1953	3	the	the	DT
cord-015021-pol2qm74	1953	4	mechanism	mechanism	NN
cord-015021-pol2qm74	1953	5	of	of	IN
cord-015021-pol2qm74	1953	6	this	this	DT
cord-015021-pol2qm74	1953	7	injury	injury	NN
cord-015021-pol2qm74	1953	8	remains	remain	VBZ
cord-015021-pol2qm74	1953	9	unclear	unclear	JJ
cord-015021-pol2qm74	1953	10	.	.	.
cord-015021-pol2qm74	1954	1	We	-PRON-	PRP
cord-015021-pol2qm74	1954	2	hypothesised	hypothesise	VBD
cord-015021-pol2qm74	1954	3	that	that	IN
cord-015021-pol2qm74	1954	4	the	the	DT
cord-015021-pol2qm74	1954	5	mechanism	mechanism	NN
cord-015021-pol2qm74	1954	6	of	of	IN
cord-015021-pol2qm74	1954	7	tissue	tissue	NN
cord-015021-pol2qm74	1954	8	injury	injury	NN
cord-015021-pol2qm74	1954	9	is	be	VBZ
cord-015021-pol2qm74	1954	10	due	due	JJ
cord-015021-pol2qm74	1954	11	to	to	IN
cord-015021-pol2qm74	1954	12	EC	EC	NNP
cord-015021-pol2qm74	1954	13	necrosis	necrosis	NN
cord-015021-pol2qm74	1954	14	with	with	IN
cord-015021-pol2qm74	1954	15	release	release	NN
cord-015021-pol2qm74	1954	16	of	of	IN
cord-015021-pol2qm74	1954	17	toxic	toxic	JJ
cord-015021-pol2qm74	1954	18	products	product	NNS
cord-015021-pol2qm74	1954	19	and	and	CC
cord-015021-pol2qm74	1954	20	that	that	DT
cord-015021-pol2qm74	1954	21	activated	activate	VBN
cord-015021-pol2qm74	1954	22	PMN	PMN	NNP
cord-015021-pol2qm74	1954	23	are	be	VBP
cord-015021-pol2qm74	1954	24	responsible	responsible	JJ
cord-015021-pol2qm74	1954	25	.	.	.
cord-015021-pol2qm74	1955	1	Human	Human	NNP
cord-015021-pol2qm74	1955	2	PMN	PMN	NNP
cord-015021-pol2qm74	1955	3	were	be	VBD
cord-015021-pol2qm74	1955	4	obtained	obtain	VBN
cord-015021-pol2qm74	1955	5	from	from	IN
cord-015021-pol2qm74	1955	6	healthy	healthy	JJ
cord-015021-pol2qm74	1955	7	donors	donor	NNS
cord-015021-pol2qm74	1955	8	,	,	,
cord-015021-pol2qm74	1955	9	separated	separate	VBN
cord-015021-pol2qm74	1955	10	by	by	IN
cord-015021-pol2qm74	1955	11	density	density	NN
cord-015021-pol2qm74	1955	12	gradient	gradient	NN
cord-015021-pol2qm74	1955	13	,	,	,
cord-015021-pol2qm74	1955	14	and	and	CC
cord-015021-pol2qm74	1955	15	activated	activate	VBN
cord-015021-pol2qm74	1955	16	with	with	IN
cord-015021-pol2qm74	1955	17	LPS	LPS	NNP
cord-015021-pol2qm74	1955	18	(	(	-LRB-
cord-015021-pol2qm74	1955	19	50ng	50ng	NNP
cord-015021-pol2qm74	1955	20	/	/	SYM
cord-015021-pol2qm74	1955	21	ml	ml	NN
cord-015021-pol2qm74	1955	22	)	)	-RRB-
cord-015021-pol2qm74	1955	23	,	,	,
cord-015021-pol2qm74	1955	24	TNF(10ng	TNF(10ng	NNP
cord-015021-pol2qm74	1955	25	/	/	SYM
cord-015021-pol2qm74	1955	26	ml	ml	NNP
cord-015021-pol2qm74	1955	27	)	)	-RRB-
cord-015021-pol2qm74	1955	28	,	,	,
cord-015021-pol2qm74	1955	29	and	and	CC
cord-015021-pol2qm74	1955	30	LPS	LPS	NNP
cord-015021-pol2qm74	1955	31	/	/	SYM
cord-015021-pol2qm74	1955	32	TNF(25ng/10ng	TNF(25ng/10ng	NNP
cord-015021-pol2qm74	1955	33	/	/	SYM
cord-015021-pol2qm74	1955	34	ml	ml	NN
cord-015021-pol2qm74	1955	35	)	)	-RRB-
cord-015021-pol2qm74	1955	36	.	.	.
cord-015021-pol2qm74	1956	1	Cultures	culture	NNS
cord-015021-pol2qm74	1956	2	of	of	IN
cord-015021-pol2qm74	1956	3	the	the	DT
cord-015021-pol2qm74	1956	4	human	human	JJ
cord-015021-pol2qm74	1956	5	EC	EC	NNP
cord-015021-pol2qm74	1956	6	tine(ECV-304	tine(ECV-304	NNP
cord-015021-pol2qm74	1956	7	)	)	-RRB-
cord-015021-pol2qm74	1956	8	were	be	VBD
cord-015021-pol2qm74	1956	9	used	use	VBN
cord-015021-pol2qm74	1956	10	as	as	IN
cord-015021-pol2qm74	1956	11	surrogates	surrogate	NNS
cord-015021-pol2qm74	1956	12	of	of	IN
cord-015021-pol2qm74	1956	13	the	the	DT
cord-015021-pol2qm74	1956	14	microvasculature	microvasculature	NN
cord-015021-pol2qm74	1956	15	,	,	,
cord-015021-pol2qm74	1956	16	were	be	VBD
cord-015021-pol2qm74	1956	17	exposed	expose	VBN
cord-015021-pol2qm74	1956	18	to	to	IN
cord-015021-pol2qm74	1956	19	either	either	CC
cord-015021-pol2qm74	1956	20	LPS	LPS	NNP
cord-015021-pol2qm74	1956	21	,	,	,
cord-015021-pol2qm74	1956	22	TNF	TNF	NNP
cord-015021-pol2qm74	1956	23	,	,	,
cord-015021-pol2qm74	1956	24	LPS	LPS	NNP
cord-015021-pol2qm74	1956	25	/	/	SYM
cord-015021-pol2qm74	1956	26	TNF	TNF	NNP
cord-015021-pol2qm74	1956	27	and	and	CC
cord-015021-pol2qm74	1956	28	PMN	PMN	NNP
cord-015021-pol2qm74	1956	29	activated	activate	VBD
cord-015021-pol2qm74	1956	30	with	with	IN
cord-015021-pol2qm74	1956	31	LPS	LPS	NNP
cord-015021-pol2qm74	1956	32	,	,	,
cord-015021-pol2qm74	1956	33	TNF	TNF	NNP
cord-015021-pol2qm74	1956	34	,	,	,
cord-015021-pol2qm74	1956	35	LPS	LPS	NNP
cord-015021-pol2qm74	1956	36	/	/	SYM
cord-015021-pol2qm74	1956	37	TNF	TNF	NNP
cord-015021-pol2qm74	1956	38	and	and	CC
cord-015021-pol2qm74	1956	39	incubated	incubate	VBN
cord-015021-pol2qm74	1956	40	for	for	IN
cord-015021-pol2qm74	1956	41	6	6	CD
cord-015021-pol2qm74	1956	42	,	,	,
cord-015021-pol2qm74	1956	43	12	12	CD
cord-015021-pol2qm74	1956	44	,	,	,
cord-015021-pol2qm74	1956	45	18	18	CD
cord-015021-pol2qm74	1956	46	,	,	,
cord-015021-pol2qm74	1956	47	and	and	CC
cord-015021-pol2qm74	1956	48	24hrs	24hrs	NN
cord-015021-pol2qm74	1956	49	.	.	.
cord-015021-pol2qm74	1957	1	EC	EC	NNP
cord-015021-pol2qm74	1957	2	necrosis	necrosis	NN
cord-015021-pol2qm74	1957	3	was	be	VBD
cord-015021-pol2qm74	1957	4	assessed	assess	VBN
cord-015021-pol2qm74	1957	5	by	by	IN
cord-015021-pol2qm74	1957	6	a	a	DT
cord-015021-pol2qm74	1957	7	51Cr	51cr	CD
cord-015021-pol2qm74	1957	8	release	release	NN
cord-015021-pol2qm74	1957	9	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	1957	10	assay	assay	NN
cord-015021-pol2qm74	1957	11	.	.	.
cord-015021-pol2qm74	1958	1	PMN	pmn	NN
cord-015021-pol2qm74	1958	2	activation	activation	NN
cord-015021-pol2qm74	1958	3	was	be	VBD
cord-015021-pol2qm74	1958	4	assessed	assess	VBN
cord-015021-pol2qm74	1958	5	by	by	IN
cord-015021-pol2qm74	1958	6	CD1	CD1	NNP
cord-015021-pol2qm74	1958	7	lb	lb	JJ
cord-015021-pol2qm74	1958	8	receptor	receptor	NN
cord-015021-pol2qm74	1958	9	expression	expression	NN
cord-015021-pol2qm74	1958	10	and	and	CC
cord-015021-pol2qm74	1958	11	respiratory	respiratory	JJ
cord-015021-pol2qm74	1958	12	burst	burst	NN
cord-015021-pol2qm74	1958	13	activity	activity	NN
cord-015021-pol2qm74	1959	1	6hr	6hr	NN
cord-015021-pol2qm74	1959	2	0_+0	0_+0	CD
cord-015021-pol2qm74	1960	1	1.7-+	1.7-+	NNP
cord-015021-pol2qm74	1960	2	1	1	CD
cord-015021-pol2qm74	1961	1	0-+0	0-+0	CD
cord-015021-pol2qm74	1961	2	3.2_+	3.2_+	NN
cord-015021-pol2qm74	1961	3	1	1	CD
cord-015021-pol2qm74	1961	4	0_+0	0_+0	CD
cord-015021-pol2qm74	1961	5	4.4_+	4.4_+	CD
cord-015021-pol2qm74	1961	6	1	1	CD
cord-015021-pol2qm74	1961	7	0_+0	0_+0	CD
cord-015021-pol2qm74	1962	1	2.3_+0.9	2.3_+0.9	CD
cord-015021-pol2qm74	1962	2	12hr	12hr	NN
cord-015021-pol2qm74	1962	3	0	0	CD
cord-015021-pol2qm74	1962	4	+	+	SYM
cord-015021-pol2qm74	1962	5	0	0	CD
cord-015021-pol2qm74	1963	1	3.24_3	3.24_3	LS
cord-015021-pol2qm74	1963	2	0_+0	0_+0	CD
cord-015021-pol2qm74	1964	1	9.3_+3	9.3_+3	CD
cord-015021-pol2qm74	1964	2	0_+0	0_+0	CD
cord-015021-pol2qm74	1964	3	11_+3	11_+3	CD
cord-015021-pol2qm74	1965	1	"	"	``
cord-015021-pol2qm74	1965	2	0+_0	0+_0	CD
cord-015021-pol2qm74	1965	3	12	12	CD
cord-015021-pol2qm74	1966	1	+	+	LS
cord-015021-pol2qm74	1966	2	--2.1	--2.1	:
cord-015021-pol2qm74	1966	3	"	"	''
cord-015021-pol2qm74	1966	4	lghr	lghr	NNP
cord-015021-pol2qm74	1966	5	04	04	CD
cord-015021-pol2qm74	1966	6	-	-	SYM
cord-015021-pol2qm74	1966	7	0	0	CD
cord-015021-pol2qm74	1966	8	0.9_+2	0.9_+2	CD
cord-015021-pol2qm74	1966	9	0+_0	0+_0	CD
cord-015021-pol2qm74	1967	1	284	284	CD
cord-015021-pol2qm74	1967	2	-	-	SYM
cord-015021-pol2qm74	1967	3	12	12	CD
cord-015021-pol2qm74	1968	1	"	"	``
cord-015021-pol2qm74	1968	2	O	o	UH
cord-015021-pol2qm74	1968	3	:	:	:
cord-015021-pol2qm74	1968	4	fO	fO	.
cord-015021-pol2qm74	1969	1	25,12	25,12	CD
cord-015021-pol2qm74	1969	2	"	"	``
cord-015021-pol2qm74	1969	3	0~0	0~0	CD
cord-015021-pol2qm74	1969	4	30	30	CD
cord-015021-pol2qm74	1970	1	+	+	CC
cord-015021-pol2qm74	1970	2	-9.5	-9.5	NN
cord-015021-pol2qm74	1971	1	*	*	NFP
cord-015021-pol2qm74	1971	2	24hr	24hr	NN
cord-015021-pol2qm74	1971	3	0_+0	0_+0	CD
cord-015021-pol2qm74	1972	1	4.14	4.14	CD
cord-015021-pol2qm74	1972	2	-	-	SYM
cord-015021-pol2qm74	1972	3	4	4	CD
cord-015021-pol2qm74	1973	1	0-+0	0-+0	CD
cord-015021-pol2qm74	1973	2	33+_3	33+_3	CD
cord-015021-pol2qm74	1974	1	*	*	NFP
cord-015021-pol2qm74	1974	2	0_+0	0_+0	CD
cord-015021-pol2qm74	1974	3	30_+9	30_+9	CD
cord-015021-pol2qm74	1975	1	*	*	NFP
cord-015021-pol2qm74	1975	2	0_+0	0_+0	NFP
cord-015021-pol2qm74	1975	3	32_+10	32_+10	CD
cord-015021-pol2qm74	1975	4	"	"	``
cord-015021-pol2qm74	1975	5	Data	data	NN
cord-015021-pol2qm74	1975	6	=	=	SYM
cord-015021-pol2qm74	1975	7	EC	EC	NNP
cord-015021-pol2qm74	1975	8	%	%	NN
cord-015021-pol2qm74	1975	9	necrosis	necrosis	NN
cord-015021-pol2qm74	1976	1	mean_+SD	mean_+SD	NNP
cord-015021-pol2qm74	1976	2	Stats	stat	NNS
cord-015021-pol2qm74	1976	3	:	:	:
cord-015021-pol2qm74	1976	4	Student	student	NN
cord-015021-pol2qm74	1976	5	's	's	POS
cord-015021-pol2qm74	1976	6	t	t	NN
cord-015021-pol2qm74	1976	7	-	-	HYPH
cord-015021-pol2qm74	1976	8	test	test	NN
cord-015021-pol2qm74	1976	9	with	with	IN
cord-015021-pol2qm74	1976	10	significance	significance	NN
cord-015021-pol2qm74	1977	1	(	(	-LRB-
cord-015021-pol2qm74	1977	2	*	*	NFP
cord-015021-pol2qm74	1977	3	)	)	-RRB-
cord-015021-pol2qm74	1977	4	set	set	VBN
cord-015021-pol2qm74	1977	5	at	at	IN
cord-015021-pol2qm74	1977	6	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	1977	7	vs	vs	IN
cord-015021-pol2qm74	1977	8	control	control	NN
cord-015021-pol2qm74	1977	9	.	.	.
cord-015021-pol2qm74	1978	1	(	(	-LRB-
cord-015021-pol2qm74	1978	2	Our	-PRON-	PRP$
cord-015021-pol2qm74	1978	3	previous	previous	JJ
cord-015021-pol2qm74	1978	4	studies	study	NNS
cord-015021-pol2qm74	1978	5	have	have	VBP
cord-015021-pol2qm74	1978	6	indicated	indicate	VBN
cord-015021-pol2qm74	1978	7	that	that	IN
cord-015021-pol2qm74	1978	8	despite	despite	IN
cord-015021-pol2qm74	1978	9	the	the	DT
cord-015021-pol2qm74	1978	10	increased	increase	VBN
cord-015021-pol2qm74	1978	11	cardiac	cardiac	JJ
cord-015021-pol2qm74	1978	12	output	output	NN
cord-015021-pol2qm74	1978	13	and	and	CC
cord-015021-pol2qm74	1978	14	maintenance	maintenance	NN
cord-015021-pol2qm74	1978	15	of	of	IN
cord-015021-pol2qm74	1978	16	tissue	tissue	NN
cord-015021-pol2qm74	1978	17	perfusion	perfusion	NN
cord-015021-pol2qm74	1978	18	,	,	,
cord-015021-pol2qm74	1978	19	hepatoceliular	hepatoceliular	JJ
cord-015021-pol2qm74	1978	20	dysfunction	dysfunction	NN
cord-015021-pol2qm74	1978	21	occurs	occur	VBZ
cord-015021-pol2qm74	1978	22	during	during	IN
cord-015021-pol2qm74	1978	23	early	early	JJ
cord-015021-pol2qm74	1978	24	sepsis	sepsis	NN
cord-015021-pol2qm74	1978	25	.	.	.
cord-015021-pol2qm74	1979	1	Nonetheless	nonetheless	RB
cord-015021-pol2qm74	1979	2	,	,	,
cord-015021-pol2qm74	1979	3	it	-PRON-	PRP
cord-015021-pol2qm74	1979	4	remains	remain	VBZ
cord-015021-pol2qm74	1979	5	unknown	unknown	JJ
cord-015021-pol2qm74	1979	6	whether	whether	IN
cord-015021-pol2qm74	1979	7	vascular	vascular	JJ
cord-015021-pol2qm74	1979	8	endothelial	endothelial	JJ
cord-015021-pol2qm74	1979	9	cell	cell	NN
cord-015021-pol2qm74	1979	10	function	function	NN
cord-015021-pol2qm74	1979	11	(	(	-LRB-
cord-015021-pol2qm74	1979	12	i.e.	i.e.	FW
cord-015021-pol2qm74	1979	13	,	,	,
cord-015021-pol2qm74	1979	14	the	the	DT
cord-015021-pol2qm74	1979	15	release	release	NN
cord-015021-pol2qm74	1979	16	of	of	IN
cord-015021-pol2qm74	1979	17	endothelium	endothelium	NN
cord-015021-pol2qm74	1979	18	-	-	HYPH
cord-015021-pol2qm74	1979	19	derived	derive	VBN
cord-015021-pol2qm74	1979	20	relaxing	relax	VBG
cord-015021-pol2qm74	1979	21	factor	factor	NN
cord-015021-pol2qm74	1979	22	/	/	SYM
cord-015021-pol2qm74	1979	23	nitric	nitric	NN
cord-015021-pol2qm74	1979	24	oxide	oxide	NN
cord-015021-pol2qm74	1979	25	)	)	-RRB-
cord-015021-pol2qm74	1979	26	is	be	VBZ
cord-015021-pol2qm74	1979	27	depressed	depress	VBN
cord-015021-pol2qm74	1979	28	under	under	IN
cord-015021-pol2qm74	1979	29	such	such	JJ
cord-015021-pol2qm74	1979	30	conditions	condition	NNS
cord-015021-pol2qm74	1979	31	and	and	CC
cord-015021-pol2qm74	1979	32	,	,	,
cord-015021-pol2qm74	1979	33	if	if	IN
cord-015021-pol2qm74	1979	34	so	so	RB
cord-015021-pol2qm74	1979	35	,	,	,
cord-015021-pol2qm74	1979	36	whether	whether	IN
cord-015021-pol2qm74	1979	37	endothelial	endothelial	JJ
cord-015021-pol2qm74	1979	38	cell	cell	NN
cord-015021-pol2qm74	1979	39	dysfunction	dysfunction	NN
cord-015021-pol2qm74	1979	40	also	also	RB
cord-015021-pol2qm74	1979	41	occurs	occur	VBZ
cord-015021-pol2qm74	1979	42	at	at	IN
cord-015021-pol2qm74	1979	43	the	the	DT
cord-015021-pol2qm74	1979	44	microcirculatory	microcirculatory	JJ
cord-015021-pol2qm74	1979	45	level	level	NN
cord-015021-pol2qm74	1979	46	.	.	.
cord-015021-pol2qm74	1980	1	To	to	TO
cord-015021-pol2qm74	1980	2	determine	determine	VB
cord-015021-pol2qm74	1980	3	this	this	DT
cord-015021-pol2qm74	1980	4	,	,	,
cord-015021-pol2qm74	1980	5	rats	rat	NNS
cord-015021-pol2qm74	1980	6	were	be	VBD
cord-015021-pol2qm74	1980	7	subjected	subject	VBN
cord-015021-pol2qm74	1980	8	to	to	IN
cord-015021-pol2qm74	1980	9	sepsis	sepsis	NN
cord-015021-pol2qm74	1980	10	by	by	IN
cord-015021-pol2qm74	1980	11	cecal	cecal	JJ
cord-015021-pol2qm74	1980	12	ligation	ligation	NN
cord-015021-pol2qm74	1980	13	and	and	CC
cord-015021-pol2qm74	1980	14	puncture	puncture	NN
cord-015021-pol2qm74	1980	15	(	(	-LRB-
cord-015021-pol2qm74	1980	16	CLP	CLP	NNP
cord-015021-pol2qm74	1980	17	)	)	-RRB-
cord-015021-pol2qm74	1980	18	,	,	,
cord-015021-pol2qm74	1980	19	following	follow	VBG
cord-015021-pol2qm74	1980	20	which	which	WDT
cord-015021-pol2qm74	1980	21	these	these	DT
cord-015021-pol2qm74	1980	22	and	and	CC
cord-015021-pol2qm74	1980	23	corresponding	corresponding	JJ
cord-015021-pol2qm74	1980	24	shams	sham	NNS
cord-015021-pol2qm74	1980	25	received	receive	VBD
cord-015021-pol2qm74	1980	26	3	3	CD
cord-015021-pol2qm74	1980	27	ml/100	ml/100	NNS
cord-015021-pol2qm74	1980	28	g	g	NNP
cord-015021-pol2qm74	1980	29	BW	BW	NNP
cord-015021-pol2qm74	1980	30	normal	normal	JJ
cord-015021-pol2qm74	1980	31	saline	saline	NN
cord-015021-pol2qm74	1980	32	.	.	.
cord-015021-pol2qm74	1981	1	At	at	IN
cord-015021-pol2qm74	1981	2	5	5	CD
cord-015021-pol2qm74	1981	3	hr	hr	NN
cord-015021-pol2qm74	1981	4	after	after	IN
cord-015021-pol2qm74	1981	5	CLP	CLP	NNP
cord-015021-pol2qm74	1981	6	(	(	-LRB-
cord-015021-pol2qm74	1981	7	hyperdynamic	hyperdynamic	NNP
cord-015021-pol2qm74	1981	8	sepsis	sepsis	NN
cord-015021-pol2qm74	1981	9	)	)	-RRB-
cord-015021-pol2qm74	1981	10	or	or	CC
cord-015021-pol2qm74	1981	11	sham	sham	JJ
cord-015021-pol2qm74	1981	12	operation	operation	NN
cord-015021-pol2qm74	1981	13	,	,	,
cord-015021-pol2qm74	1981	14	the	the	DT
cord-015021-pol2qm74	1981	15	thoracic	thoracic	JJ
cord-015021-pol2qm74	1981	16	aorta	aorta	NN
cord-015021-pol2qm74	1981	17	was	be	VBD
cord-015021-pol2qm74	1981	18	isolated	isolate	VBN
cord-015021-pol2qm74	1981	19	,	,	,
cord-015021-pol2qm74	1981	20	cut	cut	VBN
cord-015021-pol2qm74	1981	21	into	into	IN
cord-015021-pol2qm74	1981	22	rings	ring	NNS
cord-015021-pol2qm74	1981	23	,	,	,
cord-015021-pol2qm74	1981	24	and	and	CC
cord-015021-pol2qm74	1981	25	placed	place	VBN
cord-015021-pol2qm74	1981	26	in	in	IN
cord-015021-pol2qm74	1981	27	organ	organ	NN
cord-015021-pol2qm74	1981	28	chambers	chamber	NNS
cord-015021-pol2qm74	1981	29	.	.	.
cord-015021-pol2qm74	1982	1	Norepinephrine	Norepinephrine	NNP
cord-015021-pol2qm74	1982	2	(	(	-LRB-
cord-015021-pol2qm74	1982	3	NE	NE	NNP
cord-015021-pol2qm74	1982	4	,	,	,
cord-015021-pol2qm74	1982	5	2xI0	2xi0	CD
cord-015021-pol2qm74	1982	6	-7	-7	NNP
cord-015021-pol2qm74	1982	7	M	M	NNP
cord-015021-pol2qm74	1982	8	)	)	-RRB-
cord-015021-pol2qm74	1982	9	was	be	VBD
cord-015021-pol2qm74	1982	10	used	use	VBN
cord-015021-pol2qm74	1982	11	to	to	TO
cord-015021-pol2qm74	1982	12	achieve	achieve	VB
cord-015021-pol2qm74	1982	13	near	near	RB
cord-015021-pol2qm74	1982	14	-	-	HYPH
cord-015021-pol2qm74	1982	15	maximal	maximal	JJ
cord-015021-pol2qm74	1982	16	contraction	contraction	NN
cord-015021-pol2qm74	1982	17	.	.	.
cord-015021-pol2qm74	1983	1	Responses	response	NNS
cord-015021-pol2qm74	1983	2	for	for	IN
cord-015021-pol2qm74	1983	3	an	an	DT
cord-015021-pol2qm74	1983	4	endothelium	endothelium	NN
cord-015021-pol2qm74	1983	5	-	-	HYPH
cord-015021-pol2qm74	1983	6	dependeut	dependeut	VBN
cord-015021-pol2qm74	1983	7	vasodilator	vasodilator	NN
cord-015021-pol2qm74	1983	8	,	,	,
cord-015021-pol2qm74	1983	9	acetylcholine	acetylcholine	NN
cord-015021-pol2qm74	1983	10	(	(	-LRB-
cord-015021-pol2qm74	1983	11	ACh	ACh	NNP
cord-015021-pol2qm74	1983	12	,	,	,
cord-015021-pol2qm74	1983	13	via	via	IN
cord-015021-pol2qm74	1983	14	nitric	nitric	NN
cord-015021-pol2qm74	1983	15	oxide	oxide	NN
cord-015021-pol2qm74	1983	16	)	)	-RRB-
cord-015021-pol2qm74	1983	17	,	,	,
cord-015021-pol2qm74	1983	18	were	be	VBD
cord-015021-pol2qm74	1983	19	determined	determine	VBN
cord-015021-pol2qm74	1983	20	.	.	.
cord-015021-pol2qm74	1984	1	In	in	IN
cord-015021-pol2qm74	1984	2	additional	additional	JJ
cord-015021-pol2qm74	1984	3	studies	study	NNS
cord-015021-pol2qm74	1984	4	,	,	,
cord-015021-pol2qm74	1984	5	the	the	DT
cord-015021-pol2qm74	1984	6	small	small	JJ
cord-015021-pol2qm74	1984	7	gut	gut	NN
cord-015021-pol2qm74	1984	8	was	be	VBD
cord-015021-pol2qm74	1984	9	isolated	isolate	VBN
cord-015021-pol2qm74	1984	10	at	at	IN
cord-015021-pol2qm74	1984	11	5	5	CD
cord-015021-pol2qm74	1984	12	hr	hr	NN
cord-015021-pol2qm74	1984	13	post	post	NN
cord-015021-pol2qm74	1984	14	-	-	JJ
cord-015021-pol2qm74	1984	15	CLP	clp	NN
cord-015021-pol2qm74	1984	16	.	.	.
cord-015021-pol2qm74	1985	1	After	after	IN
cord-015021-pol2qm74	1985	2	pre	pre	JJ
cord-015021-pol2qm74	1985	3	-	-	NN
cord-015021-pol2qm74	1985	4	contraction	contraction	NN
cord-015021-pol2qm74	1985	5	of	of	IN
cord-015021-pol2qm74	1985	6	blood	blood	NN
cord-015021-pol2qm74	1985	7	vessels	vessel	NNS
cord-015021-pol2qm74	1985	8	in	in	IN
cord-015021-pol2qm74	1985	9	the	the	DT
cord-015021-pol2qm74	1985	10	isolated	isolate	VBN
cord-015021-pol2qm74	1985	11	gut	gut	NN
cord-015021-pol2qm74	1985	12	with	with	IN
cord-015021-pol2qm74	1985	13	5xl04	5xl04	CD
cord-015021-pol2qm74	1985	14	M	M	NNP
cord-015021-pol2qm74	1985	15	NE	NE	NNP
cord-015021-pol2qm74	1985	16	,	,	,
cord-015021-pol2qm74	1985	17	vascular	vascular	JJ
cord-015021-pol2qm74	1985	18	responses	response	NNS
cord-015021-pol2qm74	1985	19	to	to	IN
cord-015021-pol2qm74	1985	20	ACh	ACh	NNP
cord-015021-pol2qm74	1985	21	(	(	-LRB-
cord-015021-pol2qm74	1985	22	5x10	5x10	CD
cord-015021-pol2qm74	1985	23	6	6	CD
cord-015021-pol2qm74	1985	24	M	M	NNP
cord-015021-pol2qm74	1985	25	)	)	-RRB-
cord-015021-pol2qm74	1985	26	and	and	CC
cord-015021-pol2qm74	1985	27	an	an	DT
cord-015021-pol2qm74	1985	28	endotheliumindependent	endotheliumindependent	NN
cord-015021-pol2qm74	1985	29	vasodiiator	vasodiiator	NN
cord-015021-pol2qm74	1985	30	,	,	,
cord-015021-pol2qm74	1985	31	nitroglycerine	nitroglycerine	NN
cord-015021-pol2qm74	1985	32	(	(	-LRB-
cord-015021-pol2qm74	1985	33	NTG	NTG	NNP
cord-015021-pol2qm74	1985	34	,	,	,
cord-015021-pol2qm74	1985	35	5xl0	5xl0	CD
cord-015021-pol2qm74	1985	36	-7	-7	IN
cord-015021-pol2qm74	1985	37	M	M	NNP
cord-015021-pol2qm74	1985	38	)	)	-RRB-
cord-015021-pol2qm74	1985	39	,	,	,
cord-015021-pol2qm74	1985	40	were	be	VBD
cord-015021-pol2qm74	1985	41	determined	determine	VBN
cord-015021-pol2qm74	1985	42	.	.	.
cord-015021-pol2qm74	1986	1	Total	total	JJ
cord-015021-pol2qm74	1986	2	vascular	vascular	JJ
cord-015021-pol2qm74	1986	3	resistance	resistance	NN
cord-015021-pol2qm74	1986	4	(	(	-LRB-
cord-015021-pol2qm74	1986	5	TVR	TVR	NNP
cord-015021-pol2qm74	1986	6	,	,	,
cord-015021-pol2qm74	1986	7	mmHg	mmHg	NNP
cord-015021-pol2qm74	1986	8	/	/	SYM
cord-015021-pol2qm74	1986	9	mi	mi	NNP
cord-015021-pol2qm74	1986	10	/	/	SYM
cord-015021-pol2qm74	1986	11	min/100	min/100	NNS
cord-015021-pol2qm74	1986	12	g	g	NNP
cord-015021-pol2qm74	1986	13	)	)	-RRB-
cord-015021-pol2qm74	1986	14	was	be	VBD
cord-015021-pol2qm74	1986	15	then	then	RB
cord-015021-pol2qm74	1986	16	calculated	calculate	VBN
cord-015021-pol2qm74	1986	17	as	as	IN
cord-015021-pol2qm74	1986	18	pressure/	pressure/	CD
cord-015021-pol2qm74	1986	19	perfusinn	perfusinn	NN
cord-015021-pol2qm74	1986	20	rate	rate	NN
cord-015021-pol2qm74	1986	21	.	.	.
cord-015021-pol2qm74	1987	1	ACh	ACh	NNP
cord-015021-pol2qm74	1987	2	-	-	HYPH
cord-015021-pol2qm74	1987	3	induced	induce	VBN
cord-015021-pol2qm74	1987	4	relaxation	relaxation	NN
cord-015021-pol2qm74	1987	5	(	(	-LRB-
cord-015021-pol2qm74	1987	6	%	%	NN
cord-015021-pol2qm74	1987	7	,	,	,
cord-015021-pol2qm74	1987	8	n=6	n=6	JJ
cord-015021-pol2qm74	1987	9	/	/	SYM
cord-015021-pol2qm74	1987	10	group	group	NN
cord-015021-pol2qm74	1987	11	)	)	-RRB-
cord-015021-pol2qm74	1987	12	in	in	IN
cord-015021-pol2qm74	1987	13	the	the	DT
cord-015021-pol2qm74	1987	14	aortic	aortic	JJ
cord-015021-pol2qm74	1987	15	rings	ring	NNS
cord-015021-pol2qm74	1987	16	were	be	VBD
cord-015021-pol2qm74	1987	17	:	:	:
cord-015021-pol2qm74	1988	1	ACh	ACh	NNP
cord-015021-pol2qm74	1988	2	lxl0	lxl0	NNP
cord-015021-pol2qm74	1988	3	i	i	NNP
cord-015021-pol2qm74	1988	4	~	~	NFP
cord-015021-pol2qm74	1988	5	s	s	NNP
cord-015021-pol2qm74	1988	6	,	,	,
cord-015021-pol2qm74	1989	1	sT	sT	NNP
cord-015021-pol2qm74	1989	2	-	-	HYPH
cord-015021-pol2qm74	1989	3	in	in	IN
cord-015021-pol2qm74	1989	4	~	~	NFP
cord-015021-pol2qm74	1989	5	~	~	NFP
cord-015021-pol2qm74	1989	6	significantly	significantly	RB
cord-015021-pol2qm74	1989	7	at	at	IN
cord-015021-pol2qm74	1989	8	5	5	CD
cord-015021-pol2qm74	1989	9	hr	hr	NN
cord-015021-pol2qm74	1989	10	post	post	NN
cord-015021-pol2qm74	1989	11	-	-	JJ
cord-015021-pol2qm74	1989	12	CLP	clp	NN
cord-015021-pol2qm74	1989	13	(	(	-LRB-
cord-015021-pol2qm74	1989	14	i.e.	i.e.	FW
cord-015021-pol2qm74	1989	15	,	,	,
cord-015021-pol2qm74	1989	16	increased	increase	VBN
cord-015021-pol2qm74	1989	17	*	*	NFP
cord-015021-pol2qm74	1989	18	P(O	p(o	NN
cord-015021-pol2qm74	1989	19	05	05	CD
cord-015021-pol2qm74	1989	20	vs.	vs.	IN
cord-015021-pol2qm74	1989	21	Sham	Sham	NNP
cord-015021-pol2qm74	1989	22	;	;	:
cord-015021-pol2qm74	1989	23	N-4	N-4	NNP
cord-015021-pol2qm74	1989	24	per	per	IN
cord-015021-pol2qm74	1989	25	group	group	NN
cord-015021-pol2qm74	1989	26	.	.	.
cord-015021-pol2qm74	1990	1	TVR	TVR	NNP
cord-015021-pol2qm74	1990	2	)	)	-RRB-
cord-015021-pol2qm74	1991	1	in	in	IN
cord-015021-pol2qm74	1991	2	the	the	DT
cord-015021-pol2qm74	1991	3	absence	absence	NN
cord-015021-pol2qm74	1991	4	of	of	IN
cord-015021-pol2qm74	1991	5	any	any	DT
cord-015021-pol2qm74	1991	6	changes	change	NNS
cord-015021-pol2qm74	1991	7	in	in	IN
cord-015021-pol2qm74	1991	8	NTGinduced	ntginduced	JJ
cord-015021-pol2qm74	1991	9	relaxation	relaxation	NN
cord-015021-pol2qm74	1991	10	(	(	-LRB-
cord-015021-pol2qm74	1991	11	Fig	fig	NN
cord-015021-pol2qm74	1991	12	.	.	.
cord-015021-pol2qm74	1992	1	A	a	LS
cord-015021-pol2qm74	1992	2	)	)	-RRB-
cord-015021-pol2qm74	1992	3	.	.	.
cord-015021-pol2qm74	1993	1	Thus	thus	RB
cord-015021-pol2qm74	1993	2	,	,	,
cord-015021-pol2qm74	1993	3	the	the	DT
cord-015021-pol2qm74	1993	4	vascular	vascular	JJ
cord-015021-pol2qm74	1993	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	1993	6	cell	cell	NN
cord-015021-pol2qm74	1993	7	dysfunction	dysfunction	NN
cord-015021-pol2qm74	1993	8	observed	observe	VBN
cord-015021-pol2qm74	1993	9	in	in	IN
cord-015021-pol2qm74	1993	10	the	the	DT
cord-015021-pol2qm74	1993	11	aorta	aorta	NN
cord-015021-pol2qm74	1993	12	in	in	IN
cord-015021-pol2qm74	1993	13	early	early	JJ
cord-015021-pol2qm74	1993	14	sepsis	sepsis	NN
cord-015021-pol2qm74	1993	15	also	also	RB
cord-015021-pol2qm74	1993	16	occurs	occur	VBZ
cord-015021-pol2qm74	1993	17	at	at	IN
cord-015021-pol2qm74	1993	18	the	the	DT
cord-015021-pol2qm74	1993	19	microcirculatory	microcirculatory	JJ
cord-015021-pol2qm74	1993	20	level	level	NN
cord-015021-pol2qm74	1993	21	.	.	.
cord-015021-pol2qm74	1993	22	 	 	_SP
cord-015021-pol2qm74	1994	1	Introduction	introduction	NN
cord-015021-pol2qm74	1994	2	:	:	:
cord-015021-pol2qm74	1995	1	The	the	DT
cord-015021-pol2qm74	1995	2	cytokine	cytokine	NN
cord-015021-pol2qm74	1995	3	-	-	HYPH
cord-015021-pol2qm74	1995	4	mediated	mediate	VBN
cord-015021-pol2qm74	1995	5	adherence	adherence	NN
cord-015021-pol2qm74	1995	6	of	of	IN
cord-015021-pol2qm74	1995	7	leulcooytes	leulcooyte	NNS
cord-015021-pol2qm74	1995	8	to	to	IN
cord-015021-pol2qm74	1995	9	vascular	vascular	JJ
cord-015021-pol2qm74	1995	10	endothelium	endothelium	NN
cord-015021-pol2qm74	1995	11	is	be	VBZ
cord-015021-pol2qm74	1995	12	considered	consider	VBN
cord-015021-pol2qm74	1995	13	as	as	IN
cord-015021-pol2qm74	1995	14	an	an	DT
cord-015021-pol2qm74	1995	15	early	early	JJ
cord-015021-pol2qm74	1995	16	step	step	NN
cord-015021-pol2qm74	1995	17	in	in	IN
cord-015021-pol2qm74	1995	18	the	the	DT
cord-015021-pol2qm74	1995	19	cascade	cascade	NN
cord-015021-pol2qm74	1995	20	of	of	IN
cord-015021-pol2qm74	1995	21	pathologic	pathologic	JJ
cord-015021-pol2qm74	1995	22	reactions	reaction	NNS
cord-015021-pol2qm74	1995	23	culminating	culminate	VBG
cord-015021-pol2qm74	1995	24	in	in	IN
cord-015021-pol2qm74	1995	25	the	the	DT
cord-015021-pol2qm74	1995	26	"	"	``
cord-015021-pol2qm74	1995	27	systemic	systemic	JJ
cord-015021-pol2qm74	1995	28	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	1995	29	response	response	NN
cord-015021-pol2qm74	1995	30	syndrome	syndrome	NN
cord-015021-pol2qm74	1995	31	"	"	''
cord-015021-pol2qm74	1995	32	(	(	-LRB-
cord-015021-pol2qm74	1995	33	SIRS	sirs	UH
cord-015021-pol2qm74	1995	34	)	)	-RRB-
cord-015021-pol2qm74	1995	35	;	;	:
cord-015021-pol2qm74	1995	36	The	the	DT
cord-015021-pol2qm74	1995	37	purpose	purpose	NN
cord-015021-pol2qm74	1995	38	of	of	IN
cord-015021-pol2qm74	1995	39	this	this	DT
cord-015021-pol2qm74	1995	40	study	study	NN
cord-015021-pol2qm74	1995	41	was	be	VBD
cord-015021-pol2qm74	1995	42	to	to	TO
cord-015021-pol2qm74	1995	43	evaluate	evaluate	VB
cord-015021-pol2qm74	1995	44	the	the	DT
cord-015021-pol2qm74	1995	45	influence	influence	NN
cord-015021-pol2qm74	1995	46	of	of	IN
cord-015021-pol2qm74	1995	47	interleakin-1	interleakin-1	NNP
cord-015021-pol2qm74	1995	48	on	on	IN
cord-015021-pol2qm74	1995	49	leukooyteendothelial	leukooyteendothelial	JJ
cord-015021-pol2qm74	1995	50	cell	cell	NN
cord-015021-pol2qm74	1995	51	-	-	HYPH
cord-015021-pol2qm74	1995	52	interactions	interaction	NNS
cord-015021-pol2qm74	1995	53	and	and	CC
cord-015021-pol2qm74	1995	54	microoirculation	microoirculation	NN
cord-015021-pol2qm74	1995	55	in	in	IN
cord-015021-pol2qm74	1995	56	the	the	DT
cord-015021-pol2qm74	1995	57	liver	liver	NN
cord-015021-pol2qm74	1995	58	after	after	IN
cord-015021-pol2qm74	1995	59	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	1995	60	shock	shock	NN
cord-015021-pol2qm74	1995	61	by	by	IN
cord-015021-pol2qm74	1995	62	means	mean	NNS
cord-015021-pol2qm74	1995	63	of	of	IN
cord-015021-pol2qm74	1995	64	intravital	intravital	JJ
cord-015021-pol2qm74	1995	65	microscopy	microscopy	NNS
cord-015021-pol2qm74	1995	66	.	.	.
cord-015021-pol2qm74	1996	1	Methods	method	NNS
cord-015021-pol2qm74	1996	2	:	:	:
cord-015021-pol2qm74	1996	3	In	in	IN
cord-015021-pol2qm74	1996	4	anesthetized	anesthetized	JJ
cord-015021-pol2qm74	1996	5	female	female	JJ
cord-015021-pol2qm74	1996	6	SPRDrats	sprdrat	NNS
cord-015021-pol2qm74	1996	7	Co.w	Co.w	NNP
cord-015021-pol2qm74	1996	8	.	.	.
cord-015021-pol2qm74	1997	1	200	200	CD
cord-015021-pol2qm74	1997	2	-	-	SYM
cord-015021-pol2qm74	1997	3	230	230	CD
cord-015021-pol2qm74	1997	4	g	g	NN
cord-015021-pol2qm74	1997	5	)	)	-RRB-
cord-015021-pol2qm74	1997	6	shook	shake	VBD
cord-015021-pol2qm74	1997	7	was	be	VBD
cord-015021-pol2qm74	1997	8	induced	induce	VBN
cord-015021-pol2qm74	1997	9	by	by	IN
cord-015021-pol2qm74	1997	10	fractionated	fractionate	VBN
cord-015021-pol2qm74	1997	11	withdrawl	withdrawl	NN
cord-015021-pol2qm74	1997	12	of	of	IN
cord-015021-pol2qm74	1997	13	arterial	arterial	JJ
cord-015021-pol2qm74	1997	14	blood	blood	NN
cord-015021-pol2qm74	1997	15	within	within	IN
cord-015021-pol2qm74	1997	16	5	5	CD
cord-015021-pol2qm74	1997	17	rain	rain	NN
cord-015021-pol2qm74	1997	18	and	and	CC
cord-015021-pol2qm74	1997	19	maintained	maintain	VBD
cord-015021-pol2qm74	1997	20	for	for	IN
cord-015021-pol2qm74	1997	21	1	1	CD
cord-015021-pol2qm74	1997	22	h	h	NN
cord-015021-pol2qm74	1997	23	(	(	-LRB-
cord-015021-pol2qm74	1997	24	MAP	MAP	NNP
cord-015021-pol2qm74	1997	25	at	at	IN
cord-015021-pol2qm74	1997	26	40	40	CD
cord-015021-pol2qm74	1997	27	mm	mm	CD
cord-015021-pol2qm74	1997	28	Hg	Hg	NNP
cord-015021-pol2qm74	1997	29	,	,	,
cord-015021-pol2qm74	1997	30	Cardiac	cardiac	JJ
cord-015021-pol2qm74	1997	31	output	output	NN
cord-015021-pol2qm74	1997	32	50	50	CD
cord-015021-pol2qm74	1997	33	%	%	NN
cord-015021-pol2qm74	1997	34	of	of	IN
cord-015021-pol2qm74	1997	35	baseline	baseline	NN
cord-015021-pol2qm74	1997	36	)	)	-RRB-
cord-015021-pol2qm74	1997	37	.	.	.
cord-015021-pol2qm74	1998	1	Rats	rat	NNS
cord-015021-pol2qm74	1998	2	were	be	VBD
cord-015021-pol2qm74	1998	3	adequately	adequately	RB
cord-015021-pol2qm74	1998	4	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	1998	5	with	with	IN
cord-015021-pol2qm74	1998	6	60	60	CD
cord-015021-pol2qm74	1998	7	%	%	NN
cord-015021-pol2qm74	1998	8	of	of	IN
cord-015021-pol2qm74	1998	9	shed	shed	JJ
cord-015021-pol2qm74	1998	10	blood	blood	NN
cord-015021-pol2qm74	1998	11	and	and	CC
cord-015021-pol2qm74	1998	12	twice	twice	PDT
cord-015021-pol2qm74	1998	13	the	the	DT
cord-015021-pol2qm74	1998	14	volume	volume	NN
cord-015021-pol2qm74	1998	15	in	in	IN
cord-015021-pol2qm74	1998	16	Ringer	Ringer	NNP
cord-015021-pol2qm74	1998	17	's	's	POS
cord-015021-pol2qm74	1998	18	solution	solution	NN
cord-015021-pol2qm74	1998	19	additionally	additionally	RB
cord-015021-pol2qm74	1998	20	.	.	.
cord-015021-pol2qm74	1999	1	Following	follow	VBG
cord-015021-pol2qm74	1999	2	5	5	CD
cord-015021-pol2qm74	1999	3	h	h	NN
cord-015021-pol2qm74	1999	4	of	of	IN
cord-015021-pol2qm74	1999	5	reperfusinn	reperfusinn	NNP
cord-015021-pol2qm74	1999	6	(	(	-LRB-
cord-015021-pol2qm74	1999	7	MAP	MAP	NNP
cord-015021-pol2qm74	1999	8	>	>	XX
cord-015021-pol2qm74	2000	1	100	100	CD
cord-015021-pol2qm74	2000	2	mm	mm	CD
cord-015021-pol2qm74	2000	3	Hg	Hg	NNP
cord-015021-pol2qm74	2000	4	,	,	,
cord-015021-pol2qm74	2000	5	CO	co	NN
cord-015021-pol2qm74	2000	6	>	>	XX
cord-015021-pol2qm74	2000	7	120	120	CD
cord-015021-pol2qm74	2000	8	%	%	NN
cord-015021-pol2qm74	2000	9	of	of	IN
cord-015021-pol2qm74	2000	10	baseline	baseline	NN
cord-015021-pol2qm74	2000	11	)	)	-RRB-
cord-015021-pol2qm74	2001	1	the	the	DT
cord-015021-pol2qm74	2001	2	microcirculation	microcirculation	NN
cord-015021-pol2qm74	2001	3	in	in	IN
cord-015021-pol2qm74	2001	4	liver	liver	NN
cord-015021-pol2qm74	2001	5	lobules	lobule	NNS
cord-015021-pol2qm74	2001	6	was	be	VBD
cord-015021-pol2qm74	2001	7	examined	examine	VBN
cord-015021-pol2qm74	2001	8	by	by	IN
cord-015021-pol2qm74	2001	9	intravital	intravital	JJ
cord-015021-pol2qm74	2001	10	fluorescence	fluorescence	NN
cord-015021-pol2qm74	2001	11	microscopy	microscopy	NNS
cord-015021-pol2qm74	2001	12	after	after	IN
cord-015021-pol2qm74	2001	13	labelling	labelling	NN
cord-015021-pol2qm74	2001	14	of	of	IN
cord-015021-pol2qm74	2001	15	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2001	16	.	.	.
cord-015021-pol2qm74	2002	1	Continuous	continuous	JJ
cord-015021-pol2qm74	2002	2	administration	administration	NN
cord-015021-pol2qm74	2002	3	of	of	IN
cord-015021-pol2qm74	2002	4	IL	IL	NNP
cord-015021-pol2qm74	2002	5	-	-	HYPH
cord-015021-pol2qm74	2002	6	lra	lra	NNP
cord-015021-pol2qm74	2002	7	(	(	-LRB-
cord-015021-pol2qm74	2002	8	Synergen	Synergen	NNP
cord-015021-pol2qm74	2002	9	,	,	,
cord-015021-pol2qm74	2002	10	Boulder	Boulder	NNP
cord-015021-pol2qm74	2002	11	,	,	,
cord-015021-pol2qm74	2002	12	Colorado	Colorado	NNP
cord-015021-pol2qm74	2002	13	,	,	,
cord-015021-pol2qm74	2002	14	5mg	5mg	NN
cord-015021-pol2qm74	2002	15	/	/	SYM
cord-015021-pol2qm74	2002	16	kg	kg	NNP
cord-015021-pol2qm74	2002	17	/	/	SYM
cord-015021-pol2qm74	2002	18	h	h	NN
cord-015021-pol2qm74	2002	19	)	)	-RRB-
cord-015021-pol2qm74	2002	20	was	be	VBD
cord-015021-pol2qm74	2002	21	started	start	VBN
cord-015021-pol2qm74	2002	22	at	at	IN
cord-015021-pol2qm74	2002	23	different	different	JJ
cord-015021-pol2qm74	2002	24	time	time	NN
cord-015021-pol2qm74	2002	25	points	point	NNS
cord-015021-pol2qm74	2002	26	in	in	IN
cord-015021-pol2qm74	2002	27	a	a	DT
cord-015021-pol2qm74	2002	28	randomized	randomized	JJ
cord-015021-pol2qm74	2002	29	and	and	CC
cord-015021-pol2qm74	2002	30	blinded	blinded	JJ
cord-015021-pol2qm74	2002	31	manner	manner	NN
cord-015021-pol2qm74	2002	32	.	.	.
cord-015021-pol2qm74	2003	1	The	the	DT
cord-015021-pol2qm74	2003	2	animals	animal	NNS
cord-015021-pol2qm74	2003	3	in	in	IN
cord-015021-pol2qm74	2003	4	group	group	NN
cord-015021-pol2qm74	2003	5	P	p	NN
cord-015021-pol2qm74	2003	6	(	(	-LRB-
cord-015021-pol2qm74	2003	7	n=6	n=6	NNP
cord-015021-pol2qm74	2003	8	)	)	-RRB-
cord-015021-pol2qm74	2003	9	received	receive	VBD
cord-015021-pol2qm74	2003	10	the	the	DT
cord-015021-pol2qm74	2003	11	IL	IL	NNP
cord-015021-pol2qm74	2003	12	-	-	HYPH
cord-015021-pol2qm74	2003	13	lra	lra	NNP
cord-015021-pol2qm74	2003	14	as	as	IN
cord-015021-pol2qm74	2003	15	pretreatment	pretreatment	NN
cord-015021-pol2qm74	2003	16	beginning	begin	VBG
cord-015021-pol2qm74	2003	17	5	5	CD
cord-015021-pol2qm74	2003	18	min	min	NN
cord-015021-pol2qm74	2003	19	prior	prior	RB
cord-015021-pol2qm74	2003	20	to	to	IN
cord-015021-pol2qm74	2003	21	shock	shock	NN
cord-015021-pol2qm74	2003	22	induction	induction	NN
cord-015021-pol2qm74	2003	23	.	.	.
cord-015021-pol2qm74	2004	1	In	in	IN
cord-015021-pol2qm74	2004	2	the	the	DT
cord-015021-pol2qm74	2004	3	group	group	NN
cord-015021-pol2qm74	2004	4	T	T	NNP
cord-015021-pol2qm74	2004	5	(	(	-LRB-
cord-015021-pol2qm74	2004	6	n=6	n=6	NNP
cord-015021-pol2qm74	2004	7	)	)	-RRB-
cord-015021-pol2qm74	2004	8	the	the	DT
cord-015021-pol2qm74	2004	9	application	application	NN
cord-015021-pol2qm74	2004	10	of	of	IN
cord-015021-pol2qm74	2004	11	IL	IL	NNP
cord-015021-pol2qm74	2004	12	-	-	HYPH
cord-015021-pol2qm74	2004	13	lm	lm	NNP
cord-015021-pol2qm74	2004	14	started	start	VBD
cord-015021-pol2qm74	2004	15	at	at	IN
cord-015021-pol2qm74	2004	16	the	the	DT
cord-015021-pol2qm74	2004	17	beginning	beginning	NN
cord-015021-pol2qm74	2004	18	of	of	IN
cord-015021-pol2qm74	2004	19	the	the	DT
cord-015021-pol2qm74	2004	20	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2004	21	period	period	NN
cord-015021-pol2qm74	2004	22	with	with	IN
cord-015021-pol2qm74	2004	23	a	a	DT
cord-015021-pol2qm74	2004	24	bolus	bolus	NN
cord-015021-pol2qm74	2004	25	injection	injection	NN
cord-015021-pol2qm74	2004	26	of	of	IN
cord-015021-pol2qm74	2004	27	5	5	CD
cord-015021-pol2qm74	2004	28	mg	mg	NNP
cord-015021-pol2qm74	2004	29	/	/	SYM
cord-015021-pol2qm74	2004	30	kg	kg	NNP
cord-015021-pol2qm74	2004	31	and	and	CC
cord-015021-pol2qm74	2004	32	was	be	VBD
cord-015021-pol2qm74	2004	33	followed	follow	VBN
cord-015021-pol2qm74	2004	34	by	by	IN
cord-015021-pol2qm74	2004	35	continuons	continuon	NNS
cord-015021-pol2qm74	2004	36	administration	administration	NN
cord-015021-pol2qm74	2004	37	of	of	IN
cord-015021-pol2qm74	2004	38	5	5	CD
cord-015021-pol2qm74	2004	39	mg	mg	NNP
cord-015021-pol2qm74	2004	40	/	/	SYM
cord-015021-pol2qm74	2004	41	kg	kg	NNP
cord-015021-pol2qm74	2004	42	/	/	SYM
cord-015021-pol2qm74	2004	43	h	h	NN
cord-015021-pol2qm74	2004	44	.	.	.
cord-015021-pol2qm74	2005	1	The	the	DT
cord-015021-pol2qm74	2005	2	control	control	NN
cord-015021-pol2qm74	2005	3	group	group	NN
cord-015021-pol2qm74	2005	4	C	C	NNP
cord-015021-pol2qm74	2005	5	(	(	-LRB-
cord-015021-pol2qm74	2005	6	n=4	n=4	NNP
cord-015021-pol2qm74	2005	7	)	)	-RRB-
cord-015021-pol2qm74	2005	8	received	receive	VBD
cord-015021-pol2qm74	2005	9	equal	equal	JJ
cord-015021-pol2qm74	2005	10	volumes	volume	NNS
cord-015021-pol2qm74	2005	11	in	in	IN
cord-015021-pol2qm74	2005	12	NaC10,9	nac10,9	CD
cord-015021-pol2qm74	2005	13	%	%	NN
cord-015021-pol2qm74	2005	14	,	,	,
cord-015021-pol2qm74	2005	15	the	the	DT
cord-015021-pol2qm74	2005	16	sham	sham	NN
cord-015021-pol2qm74	2005	17	-	-	HYPH
cord-015021-pol2qm74	2005	18	operated	operate	VBN
cord-015021-pol2qm74	2005	19	group	group	NN
cord-015021-pol2qm74	2005	20	S	S	NNP
cord-015021-pol2qm74	2005	21	(	(	-LRB-
cord-015021-pol2qm74	2005	22	n=4	n=4	NNP
cord-015021-pol2qm74	2005	23	)	)	-RRB-
cord-015021-pol2qm74	2005	24	was	be	VBD
cord-015021-pol2qm74	2005	25	not	not	RB
cord-015021-pol2qm74	2005	26	exposed	expose	VBN
cord-015021-pol2qm74	2005	27	to	to	IN
cord-015021-pol2qm74	2005	28	shock	shock	NN
cord-015021-pol2qm74	2005	29	.	.	.
cord-015021-pol2qm74	2006	1	Results	result	NNS
cord-015021-pol2qm74	2006	2	:	:	:
cord-015021-pol2qm74	2007	1	Macrohemodynamics	macrohemodynamic	NNS
cord-015021-pol2qm74	2007	2	were	be	VBD
cord-015021-pol2qm74	2007	3	comparable	comparable	JJ
cord-015021-pol2qm74	2007	4	in	in	IN
cord-015021-pol2qm74	2007	5	all	all	DT
cord-015021-pol2qm74	2007	6	shook	shake	VBD
cord-015021-pol2qm74	2007	7	groups	group	NNS
cord-015021-pol2qm74	2007	8	.	.	.
cord-015021-pol2qm74	2008	1	The	the	DT
cord-015021-pol2qm74	2008	2	increased	increase	VBN
cord-015021-pol2qm74	2008	3	percentage	percentage	NN
cord-015021-pol2qm74	2008	4	of	of	IN
cord-015021-pol2qm74	2008	5	permanendy	permanendy	NNP
cord-015021-pol2qm74	2008	6	adherent	adherent	JJ
cord-015021-pol2qm74	2008	7	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2008	8	after	after	IN
cord-015021-pol2qm74	2008	9	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	2008	10	shook	shake	VBD
cord-015021-pol2qm74	2008	11	(	(	-LRB-
cord-015021-pol2qm74	2008	12	S	s	NN
cord-015021-pol2qm74	2008	13	:	:	:
cord-015021-pol2qm74	2008	14	9,1	9,1	CD
cord-015021-pol2qm74	2008	15	%	%	NN
cord-015021-pol2qm74	2008	16	+1,1	+1,1	CD
cord-015021-pol2qm74	2008	17	%	%	NN
cord-015021-pol2qm74	2008	18	;	;	:
cord-015021-pol2qm74	2008	19	C	c	NN
cord-015021-pol2qm74	2008	20	:	:	:
cord-015021-pol2qm74	2008	21	42,1	42,1	CD
cord-015021-pol2qm74	2008	22	%	%	NN
cord-015021-pol2qm74	2008	23	_	_	NN
cord-015021-pol2qm74	2008	24	+5,4	+5,4	CD
cord-015021-pol2qm74	2008	25	%	%	NN
cord-015021-pol2qm74	2008	26	)	)	-RRB-
cord-015021-pol2qm74	2008	27	was	be	VBD
cord-015021-pol2qm74	2008	28	significantly	significantly	RB
cord-015021-pol2qm74	2008	29	reduced	reduce	VBN
cord-015021-pol2qm74	2008	30	by	by	IN
cord-015021-pol2qm74	2008	31	pretreatment	pretreatment	NN
cord-015021-pol2qm74	2008	32	or	or	CC
cord-015021-pol2qm74	2008	33	treatment	treatment	NN
cord-015021-pol2qm74	2008	34	with	with	IN
cord-015021-pol2qm74	2008	35	IL	IL	NNP
cord-015021-pol2qm74	2008	36	-	-	HYPH
cord-015021-pol2qm74	2008	37	lra	lra	NNP
cord-015021-pol2qm74	2008	38	(	(	-LRB-
cord-015021-pol2qm74	2008	39	P	p	NN
cord-015021-pol2qm74	2008	40	:	:	:
cord-015021-pol2qm74	2008	41	16,9	16,9	CD
cord-015021-pol2qm74	2008	42	%	%	NN
cord-015021-pol2qm74	2008	43	-+1,9	-+1,9	:
cord-015021-pol2qm74	2008	44	%	%	NN
cord-015021-pol2qm74	2008	45	;	;	,
cord-015021-pol2qm74	2008	46	p<0.001	p<0.001	CD
cord-015021-pol2qm74	2008	47	,	,	,
cord-015021-pol2qm74	2008	48	T	t	NN
cord-015021-pol2qm74	2008	49	:	:	:
cord-015021-pol2qm74	2008	50	28,8	28,8	CD
cord-015021-pol2qm74	2008	51	%	%	NN
cord-015021-pol2qm74	2008	52	-+3,6	-+3,6	CD
cord-015021-pol2qm74	2008	53	%	%	NN
cord-015021-pol2qm74	2008	54	,	,	,
cord-015021-pol2qm74	2008	55	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	2008	56	,	,	,
cord-015021-pol2qm74	2008	57	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	2008	58	)	)	-RRB-
cord-015021-pol2qm74	2008	59	.	.	.
cord-015021-pol2qm74	2009	1	Temporary	temporary	JJ
cord-015021-pol2qm74	2009	2	adhesion	adhesion	NN
cord-015021-pol2qm74	2009	3	of	of	IN
cord-015021-pol2qm74	2009	4	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2009	5	was	be	VBD
cord-015021-pol2qm74	2009	6	unaffected	unaffected	JJ
cord-015021-pol2qm74	2009	7	by	by	IN
cord-015021-pol2qm74	2009	8	application	application	NN
cord-015021-pol2qm74	2009	9	of	of	IN
cord-015021-pol2qm74	2009	10	IL	IL	NNP
cord-015021-pol2qm74	2009	11	-	-	HYPH
cord-015021-pol2qm74	2009	12	lra	lra	NNP
cord-015021-pol2qm74	2009	13	.	.	.
cord-015021-pol2qm74	2010	1	Liver	liver	NN
cord-015021-pol2qm74	2010	2	microcirculation	microcirculation	NN
cord-015021-pol2qm74	2010	3	measured	measure	VBN
cord-015021-pol2qm74	2010	4	by	by	IN
cord-015021-pol2qm74	2010	5	volumetric	volumetric	JJ
cord-015021-pol2qm74	2010	6	blood	blood	NN
cord-015021-pol2qm74	2010	7	flow	flow	NN
cord-015021-pol2qm74	2010	8	in	in	IN
cord-015021-pol2qm74	2010	9	liver	liver	NN
cord-015021-pol2qm74	2010	10	sinusoids	sinusoid	NNS
cord-015021-pol2qm74	2010	11	and	and	CC
cord-015021-pol2qm74	2010	12	sinusoidal	sinusoidal	JJ
cord-015021-pol2qm74	2010	13	diameters	diameter	NNS
cord-015021-pol2qm74	2010	14	was	be	VBD
cord-015021-pol2qm74	2010	15	impaired	impair	VBN
cord-015021-pol2qm74	2010	16	after	after	IN
cord-015021-pol2qm74	2010	17	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	2010	18	shock	shock	NN
cord-015021-pol2qm74	2010	19	in	in	IN
cord-015021-pol2qm74	2010	20	all	all	DT
cord-015021-pol2qm74	2010	21	groups	group	NNS
cord-015021-pol2qm74	2010	22	and	and	CC
cord-015021-pol2qm74	2010	23	was	be	VBD
cord-015021-pol2qm74	2010	24	not	not	RB
cord-015021-pol2qm74	2010	25	affected	affect	VBN
cord-015021-pol2qm74	2011	1	(	(	-LRB-
cord-015021-pol2qm74	2011	2	C	C	NNP
cord-015021-pol2qm74	2011	3	:	:	:
cord-015021-pol2qm74	2011	4	31993iam3	31993iam3	CD
cord-015021-pol2qm74	2011	5	/	/	SYM
cord-015021-pol2qm74	2011	6	s	s	NNP
cord-015021-pol2qm74	2011	7	+40971um3	+40971um3	NNP
cord-015021-pol2qm74	2011	8	/	/	SYM
cord-015021-pol2qm74	2011	9	s	s	NNP
cord-015021-pol2qm74	2011	10	,	,	,
cord-015021-pol2qm74	2011	11	P	p	NN
cord-015021-pol2qm74	2011	12	:	:	:
cord-015021-pol2qm74	2012	1	32768llm3	32768llm3	NNP
cord-015021-pol2qm74	2012	2	/	/	SYM
cord-015021-pol2qm74	2012	3	s	s	POS
cord-015021-pol2qm74	2012	4	+4445}am3	+4445}am3	NNP
cord-015021-pol2qm74	2012	5	/	/	SYM
cord-015021-pol2qm74	2012	6	s	s	NNP
cord-015021-pol2qm74	2012	7	,	,	,
cord-015021-pol2qm74	2012	8	T	T	NNP
cord-015021-pol2qm74	2012	9	:	:	:
cord-015021-pol2qm74	2012	10	326211amS	326211ams	CD
cord-015021-pol2qm74	2012	11	/	/	SYM
cord-015021-pol2qm74	2012	12	s	s	NN
cord-015021-pol2qm74	2013	1	-+2998	-+2998	JJ
cord-015021-pol2qm74	2014	1	lam3	lam3	NNP
cord-015021-pol2qm74	2014	2	/	/	SYM
cord-015021-pol2qm74	2014	3	s	s	NNP
cord-015021-pol2qm74	2014	4	,	,	,
cord-015021-pol2qm74	2014	5	S	S	NNP
cord-015021-pol2qm74	2014	6	:	:	:
cord-015021-pol2qm74	2015	1	390201am3	390201am3	LS
cord-015021-pol2qm74	2015	2	/	/	SYM
cord-015021-pol2qm74	2015	3	s	s	POS
cord-015021-pol2qm74	2015	4	-+39041am3	-+39041am3	NNP
cord-015021-pol2qm74	2015	5	/	/	SYM
cord-015021-pol2qm74	2015	6	s	s	NN
cord-015021-pol2qm74	2015	7	)	)	-RRB-
cord-015021-pol2qm74	2015	8	.	.	.
cord-015021-pol2qm74	2016	1	Di.seu	Di.seu	NNP
cord-015021-pol2qm74	2016	2	~	~	NNP
cord-015021-pol2qm74	2016	3	sinn	sinn	NNP
cord-015021-pol2qm74	2016	4	:	:	:
cord-015021-pol2qm74	2016	5	The	the	DT
cord-015021-pol2qm74	2016	6	results	result	NNS
cord-015021-pol2qm74	2016	7	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2016	8	that	that	IN
cord-015021-pol2qm74	2016	9	permanent	permanent	JJ
cord-015021-pol2qm74	2016	10	adherence	adherence	NN
cord-015021-pol2qm74	2016	11	of	of	IN
cord-015021-pol2qm74	2016	12	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2016	13	to	to	IN
cord-015021-pol2qm74	2016	14	endothelium	endothelium	NN
cord-015021-pol2qm74	2016	15	is	be	VBZ
cord-015021-pol2qm74	2016	16	in	in	IN
cord-015021-pol2qm74	2016	17	part	part	NN
cord-015021-pol2qm74	2016	18	regulated	regulate	VBN
cord-015021-pol2qm74	2016	19	by	by	IN
cord-015021-pol2qm74	2016	20	IL-1	IL-1	NNP
cord-015021-pol2qm74	2016	21	.	.	.
cord-015021-pol2qm74	2017	1	Pathological	pathological	JJ
cord-015021-pol2qm74	2017	2	adherence	adherence	NN
cord-015021-pol2qm74	2017	3	could	could	MD
cord-015021-pol2qm74	2017	4	be	be	VB
cord-015021-pol2qm74	2017	5	reduced	reduce	VBN
cord-015021-pol2qm74	2017	6	by	by	IN
cord-015021-pol2qm74	2017	7	application	application	NN
cord-015021-pol2qm74	2017	8	of	of	IN
cord-015021-pol2qm74	2017	9	ILlra	ILlra	NNP
cord-015021-pol2qm74	2017	10	,	,	,
cord-015021-pol2qm74	2017	11	even	even	RB
cord-015021-pol2qm74	2017	12	given	give	VBN
cord-015021-pol2qm74	2017	13	at	at	IN
cord-015021-pol2qm74	2017	14	die	die	JJ
cord-015021-pol2qm74	2017	15	time	time	NN
cord-015021-pol2qm74	2017	16	of	of	IN
cord-015021-pol2qm74	2017	17	resuscitation	resuscitation	NN
cord-015021-pol2qm74	2017	18	.	.	.
cord-015021-pol2qm74	2018	1	The	the	DT
cord-015021-pol2qm74	2018	2	effect	effect	NN
cord-015021-pol2qm74	2018	3	of	of	IN
cord-015021-pol2qm74	2018	4	lL	lL	NNP
cord-015021-pol2qm74	2018	5	-	-	HYPH
cord-015021-pol2qm74	2018	6	lm	lm	NNP
cord-015021-pol2qm74	2018	7	on	on	IN
cord-015021-pol2qm74	2018	8	permanent	permanent	JJ
cord-015021-pol2qm74	2018	9	adhesion	adhesion	NN
cord-015021-pol2qm74	2018	10	is	be	VBZ
cord-015021-pol2qm74	2018	11	a	a	DT
cord-015021-pol2qm74	2018	12	specific	specific	JJ
cord-015021-pol2qm74	2018	13	event	event	NN
cord-015021-pol2qm74	2018	14	and	and	CC
cord-015021-pol2qm74	2018	15	might	may	MD
cord-015021-pol2qm74	2018	16	be	be	VB
cord-015021-pol2qm74	2018	17	caused	cause	VBN
cord-015021-pol2qm74	2018	18	by	by	IN
cord-015021-pol2qm74	2018	19	reduced	reduce	VBN
cord-015021-pol2qm74	2018	20	expression	expression	NN
cord-015021-pol2qm74	2018	21	of	of	IN
cord-015021-pol2qm74	2018	22	specific	specific	JJ
cord-015021-pol2qm74	2018	23	receptors	receptor	NNS
cord-015021-pol2qm74	2018	24	on	on	IN
cord-015021-pol2qm74	2018	25	sinusoidal	sinusoidal	JJ
cord-015021-pol2qm74	2018	26	endothelial	endothelial	JJ
cord-015021-pol2qm74	2018	27	cens	cen	NNS
cord-015021-pol2qm74	2018	28	and	and	CC
cord-015021-pol2qm74	2018	29	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2018	30	.	.	.
cord-015021-pol2qm74	2019	1	Objectives	objective	NNS
cord-015021-pol2qm74	2019	2	of	of	IN
cord-015021-pol2qm74	2019	3	the	the	DT
cord-015021-pol2qm74	2019	4	study	study	NN
cord-015021-pol2qm74	2019	5	.	.	.
cord-015021-pol2qm74	2020	1	The	the	DT
cord-015021-pol2qm74	2020	2	adhesion	adhesion	NN
cord-015021-pol2qm74	2020	3	of	of	IN
cord-015021-pol2qm74	2020	4	activated	activate	VBN
cord-015021-pol2qm74	2020	5	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2020	6	(	(	-LRB-
cord-015021-pol2qm74	2020	7	PMN	PMN	NNP
cord-015021-pol2qm74	2020	8	)	)	-RRB-
cord-015021-pol2qm74	2020	9	to	to	IN
cord-015021-pol2qm74	2020	10	endothelial	endothelial	JJ
cord-015021-pol2qm74	2020	11	ceils	ceil	NNS
cord-015021-pol2qm74	2020	12	(	(	-LRB-
cord-015021-pol2qm74	2020	13	EC	EC	NNP
cord-015021-pol2qm74	2020	14	)	)	-RRB-
cord-015021-pol2qm74	2020	15	and	and	CC
cord-015021-pol2qm74	2020	16	the	the	DT
cord-015021-pol2qm74	2020	17	concomitant	concomitant	JJ
cord-015021-pol2qm74	2020	18	production	production	NN
cord-015021-pol2qm74	2020	19	of	of	IN
cord-015021-pol2qm74	2020	20	reactive	reactive	JJ
cord-015021-pol2qm74	2020	21	oxygen	oxygen	NN
cord-015021-pol2qm74	2020	22	metabolites	metabolite	NNS
cord-015021-pol2qm74	2020	23	(	(	-LRB-
cord-015021-pol2qm74	2020	24	ROM	rom	NN
cord-015021-pol2qm74	2020	25	)	)	-RRB-
cord-015021-pol2qm74	2020	26	initiates	initiate	VBZ
cord-015021-pol2qm74	2020	27	organ	organ	NN
cord-015021-pol2qm74	2020	28	damage	damage	NN
cord-015021-pol2qm74	2020	29	after	after	IN
cord-015021-pol2qm74	2020	30	trauma	trauma	NN
cord-015021-pol2qm74	2020	31	,	,	,
cord-015021-pol2qm74	2020	32	sepsis	sepsis	NN
cord-015021-pol2qm74	2020	33	,	,	,
cord-015021-pol2qm74	2020	34	shock	shock	NN
cord-015021-pol2qm74	2020	35	and	and	CC
cord-015021-pol2qm74	2020	36	organ	organ	NN
cord-015021-pol2qm74	2020	37	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2020	38	.	.	.
cord-015021-pol2qm74	2021	1	Aien	Aien	NNP
cord-015021-pol2qm74	2021	2	of	of	IN
cord-015021-pol2qm74	2021	3	this	this	DT
cord-015021-pol2qm74	2021	4	study	study	NN
cord-015021-pol2qm74	2021	5	was	be	VBD
cord-015021-pol2qm74	2021	6	to	to	TO
cord-015021-pol2qm74	2021	7	investigate	investigate	VB
cord-015021-pol2qm74	2021	8	the	the	DT
cord-015021-pol2qm74	2021	9	effect	effect	NN
cord-015021-pol2qm74	2021	10	on	on	IN
cord-015021-pol2qm74	2021	11	adhesion	adhesion	NN
cord-015021-pol2qm74	2021	12	and	and	CC
cord-015021-pol2qm74	2021	13	ROM	rom	NN
cord-015021-pol2qm74	2021	14	production	production	NN
cord-015021-pol2qm74	2021	15	of	of	IN
cord-015021-pol2qm74	2021	16	the	the	DT
cord-015021-pol2qm74	2021	17	highly	highly	RB
cord-015021-pol2qm74	2021	18	water	water	NN
cord-015021-pol2qm74	2021	19	-	-	HYPH
cord-015021-pol2qm74	2021	20	soluble	soluble	JJ
cord-015021-pol2qm74	2021	21	,	,	,
cord-015021-pol2qm74	2021	22	membrane	membrane	NN
cord-015021-pol2qm74	2021	23	-	-	HYPH
cord-015021-pol2qm74	2021	24	permeable	permeable	JJ
cord-015021-pol2qm74	2021	25	and	and	CC
cord-015021-pol2qm74	2021	26	physiological	physiological	JJ
cord-015021-pol2qm74	2021	27	ascorbic	ascorbic	NN
cord-015021-pol2qm74	2021	28	acid	acid	NN
cord-015021-pol2qm74	2021	29	(	(	-LRB-
cord-015021-pol2qm74	2021	30	ASC	ASC	NNP
cord-015021-pol2qm74	2021	31	)	)	-RRB-
cord-015021-pol2qm74	2021	32	.	.	.
cord-015021-pol2qm74	2022	1	Materials	material	NNS
cord-015021-pol2qm74	2022	2	and	and	CC
cord-015021-pol2qm74	2022	3	methods	method	NNS
cord-015021-pol2qm74	2022	4	.	.	.
cord-015021-pol2qm74	2023	1	Adhesion	adhesion	NN
cord-015021-pol2qm74	2023	2	of	of	IN
cord-015021-pol2qm74	2023	3	PMN	PMN	NNP
cord-015021-pol2qm74	2023	4	to	to	TO
cord-015021-pol2qm74	2023	5	nylon	nylon	VB
cord-015021-pol2qm74	2023	6	fiber	fiber	NN
cord-015021-pol2qm74	2023	7	(	(	-LRB-
cord-015021-pol2qm74	2023	8	cell	cell	NN
cord-015021-pol2qm74	2023	9	count	count	NN
cord-015021-pol2qm74	2023	10	)	)	-RRB-
cord-015021-pol2qm74	2023	11	and	and	CC
cord-015021-pol2qm74	2023	12	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	2023	13	ROM	rom	NN
cord-015021-pol2qm74	2023	14	production	production	NN
cord-015021-pol2qm74	2023	15	(	(	-LRB-
cord-015021-pol2qm74	2023	16	chemiluminescence	chemiluminescence	NNP
cord-015021-pol2qm74	2023	17	-	-	HYPH
cord-015021-pol2qm74	2023	18	CL	cl	NN
cord-015021-pol2qm74	2023	19	-	-	HYPH
cord-015021-pol2qm74	2023	20	response	response	NN
cord-015021-pol2qm74	2023	21	)	)	-RRB-
cord-015021-pol2qm74	2023	22	were	be	VBD
cord-015021-pol2qm74	2023	23	measured	measure	VBN
cord-015021-pol2qm74	2023	24	up	up	RP
cord-015021-pol2qm74	2023	25	to	to	IN
cord-015021-pol2qm74	2023	26	6	6	CD
cord-015021-pol2qm74	2023	27	retool/1	retool/1	VBN
cord-015021-pol2qm74	2023	28	ASC	ASC	NNP
cord-015021-pol2qm74	2023	29	as	as	RB
cord-015021-pol2qm74	2023	30	well	well	RB
cord-015021-pol2qm74	2023	31	as	as	IN
cord-015021-pol2qm74	2023	32	adhesion	adhesion	NN
cord-015021-pol2qm74	2023	33	,	,	,
cord-015021-pol2qm74	2023	34	ROM	rom	NN
cord-015021-pol2qm74	2023	35	production	production	NN
cord-015021-pol2qm74	2023	36	and	and	CC
cord-015021-pol2qm74	2023	37	EC	EC	NNP
cord-015021-pol2qm74	2023	38	damage	damage	NN
cord-015021-pol2qm74	2023	39	(	(	-LRB-
cord-015021-pol2qm74	2023	40	lllln	lllln	NNP
cord-015021-pol2qm74	2023	41	-	-	HYPH
cord-015021-pol2qm74	2023	42	release	release	NN
cord-015021-pol2qm74	2023	43	from	from	IN
cord-015021-pol2qm74	2023	44	labeled	label	VBN
cord-015021-pol2qm74	2023	45	EC	EC	NNP
cord-015021-pol2qm74	2023	46	)	)	-RRB-
cord-015021-pol2qm74	2023	47	of	of	IN
cord-015021-pol2qm74	2023	48	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2023	49	-	-	HYPH
cord-015021-pol2qm74	2023	50	activated	activate	VBN
cord-015021-pol2qm74	2023	51	PMN	PMN	NNP
cord-015021-pol2qm74	2023	52	to	to	IN
cord-015021-pol2qm74	2023	53	cultered	cultere	VBN
cord-015021-pol2qm74	2023	54	EC	EC	NNP
cord-015021-pol2qm74	2023	55	moanlayers	moanlayer	NNS
cord-015021-pol2qm74	2023	56	.	.	.
cord-015021-pol2qm74	2024	1	In	in	IN
cord-015021-pol2qm74	2024	2	an	an	DT
cord-015021-pol2qm74	2024	3	in	in	IN
cord-015021-pol2qm74	2024	4	vivo	vivo	NN
cord-015021-pol2qm74	2024	5	animal	animal	NN
cord-015021-pol2qm74	2024	6	model	model	NN
cord-015021-pol2qm74	2024	7	(	(	-LRB-
cord-015021-pol2qm74	2024	8	sheep	sheep	NN
cord-015021-pol2qm74	2024	9	with	with	IN
cord-015021-pol2qm74	2024	10	lung	lung	NN
cord-015021-pol2qm74	2024	11	lymph	lymph	NN
cord-015021-pol2qm74	2024	12	fistulas	fistula	NNS
cord-015021-pol2qm74	2024	13	)	)	-RRB-
cord-015021-pol2qm74	2024	14	the	the	DT
cord-015021-pol2qm74	2024	15	effect	effect	NN
cord-015021-pol2qm74	2024	16	of	of	IN
cord-015021-pol2qm74	2024	17	ASC	ASC	NNP
cord-015021-pol2qm74	2024	18	(	(	-LRB-
cord-015021-pol2qm74	2024	19	1	1	CD
cord-015021-pol2qm74	2024	20	g	g	NN
cord-015021-pol2qm74	2024	21	/	/	SYM
cord-015021-pol2qm74	2024	22	kg	kg	NNP
cord-015021-pol2qm74	2024	23	bw	bw	NNP
cord-015021-pol2qm74	2024	24	bolus	bolus	NN
cord-015021-pol2qm74	2024	25	,	,	,
cord-015021-pol2qm74	2024	26	followed	follow	VBN
cord-015021-pol2qm74	2024	27	by	by	IN
cord-015021-pol2qm74	2024	28	0.2	0.2	CD
cord-015021-pol2qm74	2024	29	g/	g/	NNP
cord-015021-pol2qm74	2024	30	kg	kg	NNP
cord-015021-pol2qm74	2024	31	-	-	HYPH
cord-015021-pol2qm74	2024	32	h	h	NN
cord-015021-pol2qm74	2024	33	infusion	infusion	NN
cord-015021-pol2qm74	2024	34	)	)	-RRB-
cord-015021-pol2qm74	2024	35	on	on	IN
cord-015021-pol2qm74	2024	36	the	the	DT
cord-015021-pol2qm74	2024	37	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2024	38	-	-	HYPH
cord-015021-pol2qm74	2024	39	induced	induce	VBN
cord-015021-pol2qm74	2024	40	(	(	-LRB-
cord-015021-pol2qm74	2024	41	0.5	0.5	CD
cord-015021-pol2qm74	2024	42	Ixg	Ixg	NNP
cord-015021-pol2qm74	2024	43	/	/	SYM
cord-015021-pol2qm74	2024	44	kg	kg	NNP
cord-015021-pol2qm74	2024	45	bw	bw	NNP
cord-015021-pol2qm74	2024	46	)	)	-RRB-
cord-015021-pol2qm74	2024	47	neutropenia	neutropenia	NNP
cord-015021-pol2qm74	2024	48	(	(	-LRB-
cord-015021-pol2qm74	2024	49	cell	cell	NN
cord-015021-pol2qm74	2024	50	count	count	NN
cord-015021-pol2qm74	2024	51	)	)	-RRB-
cord-015021-pol2qm74	2024	52	,	,	,
cord-015021-pol2qm74	2024	53	lung	lung	NN
cord-015021-pol2qm74	2024	54	capillary	capillary	JJ
cord-015021-pol2qm74	2024	55	permeability	permeability	NN
cord-015021-pol2qm74	2024	56	damage	damage	NN
cord-015021-pol2qm74	2024	57	(	(	-LRB-
cord-015021-pol2qm74	2024	58	lung	lung	NN
cord-015021-pol2qm74	2024	59	lymph	lymph	NN
cord-015021-pol2qm74	2024	60	protein	protein	NN
cord-015021-pol2qm74	2024	61	clearance	clearance	NN
cord-015021-pol2qm74	2024	62	)	)	-RRB-
cord-015021-pol2qm74	2024	63	and	and	CC
cord-015021-pol2qm74	2024	64	ROM	rom	NN
cord-015021-pol2qm74	2024	65	production	production	NN
cord-015021-pol2qm74	2024	66	of	of	IN
cord-015021-pol2qm74	2024	67	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2024	68	(	(	-LRB-
cord-015021-pol2qm74	2024	69	zymosan	zymosan	NNP
cord-015021-pol2qm74	2024	70	-	-	HYPH
cord-015021-pol2qm74	2024	71	induced	induce	VBN
cord-015021-pol2qm74	2024	72	CL	CL	NNP
cord-015021-pol2qm74	2024	73	response	response	NN
cord-015021-pol2qm74	2024	74	)	)	-RRB-
cord-015021-pol2qm74	2024	75	was	be	VBD
cord-015021-pol2qm74	2024	76	measured	measure	VBN
cord-015021-pol2qm74	2024	77	.	.	.
cord-015021-pol2qm74	2025	1	Results	result	NNS
cord-015021-pol2qm74	2025	2	.	.	.
cord-015021-pol2qm74	2026	1	ASC	ASC	NNP
cord-015021-pol2qm74	2026	2	scavenged	scavenge	VBD
cord-015021-pol2qm74	2026	3	ROM	rom	NN
cord-015021-pol2qm74	2026	4	dose	dose	NN
cord-015021-pol2qm74	2026	5	-	-	:
cord-015021-pol2qm74	2026	6	dependently	dependently	RB
cord-015021-pol2qm74	2026	7	during	during	IN
cord-015021-pol2qm74	2026	8	adhesion	adhesion	NN
cord-015021-pol2qm74	2026	9	of	of	IN
cord-015021-pol2qm74	2026	10	PMN	PMN	NNP
cord-015021-pol2qm74	2026	11	to	to	TO
cord-015021-pol2qm74	2026	12	nylon	nylon	VB
cord-015021-pol2qm74	2026	13	fiber	fiber	NN
cord-015021-pol2qm74	2026	14	(	(	-LRB-
cord-015021-pol2qm74	2026	15	p<0.0005	p<0.0005	CC
cord-015021-pol2qm74	2026	16	at	at	IN
cord-015021-pol2qm74	2026	17	6	6	CD
cord-015021-pol2qm74	2026	18	mmol	mmol	JJ
cord-015021-pol2qm74	2026	19	/	/	SYM
cord-015021-pol2qm74	2026	20	l	l	NNP
cord-015021-pol2qm74	2026	21	ASC	ASC	NNP
cord-015021-pol2qm74	2026	22	)	)	-RRB-
cord-015021-pol2qm74	2026	23	,	,	,
cord-015021-pol2qm74	2026	24	adhesion	adhesion	NN
cord-015021-pol2qm74	2026	25	itself	-PRON-	PRP
cord-015021-pol2qm74	2026	26	was	be	VBD
cord-015021-pol2qm74	2026	27	unchanged	unchanged	JJ
cord-015021-pol2qm74	2026	28	.	.	.
cord-015021-pol2qm74	2027	1	During	during	IN
cord-015021-pol2qm74	2027	2	the	the	DT
cord-015021-pol2qm74	2027	3	activated	activate	VBN
cord-015021-pol2qm74	2027	4	PMN	PMN	NNP
cord-015021-pol2qm74	2027	5	/	/	SYM
cord-015021-pol2qm74	2027	6	EC	EC	NNP
cord-015021-pol2qm74	2027	7	interaction	interaction	NN
cord-015021-pol2qm74	2027	8	ASC	ASC	NNP
cord-015021-pol2qm74	2027	9	scavenged	scavenge	VBD
cord-015021-pol2qm74	2027	10	ROM	rom	NN
cord-015021-pol2qm74	2027	11	(	(	-LRB-
cord-015021-pol2qm74	2027	12	p<0.025	p<0.025	NNP
cord-015021-pol2qm74	2027	13	at	at	IN
cord-015021-pol2qm74	2027	14	6	6	CD
cord-015021-pol2qm74	2027	15	mmol	mmol	JJ
cord-015021-pol2qm74	2027	16	/	/	SYM
cord-015021-pol2qm74	2027	17	l	l	NNP
cord-015021-pol2qm74	2027	18	ASC	ASC	NNP
cord-015021-pol2qm74	2027	19	)	)	-RRB-
cord-015021-pol2qm74	2027	20	and	and	CC
cord-015021-pol2qm74	2027	21	reduced	reduce	VBD
cord-015021-pol2qm74	2027	22	the	the	DT
cord-015021-pol2qm74	2027	23	adhesion	adhesion	NN
cord-015021-pol2qm74	2027	24	dose	dose	NN
cord-015021-pol2qm74	2027	25	-	-	:
cord-015021-pol2qm74	2027	26	dependently	dependently	RB
cord-015021-pol2qm74	2027	27	(	(	-LRB-
cord-015021-pol2qm74	2027	28	p<0.0005	p<0.0005	CC
cord-015021-pol2qm74	2027	29	at	at	IN
cord-015021-pol2qm74	2027	30	6	6	CD
cord-015021-pol2qm74	2027	31	mmol	mmol	JJ
cord-015021-pol2qm74	2027	32	/	/	SYM
cord-015021-pol2qm74	2027	33	l	l	NNP
cord-015021-pol2qm74	2027	34	ASC	ASC	NNP
cord-015021-pol2qm74	2027	35	)	)	-RRB-
cord-015021-pol2qm74	2027	36	;	;	:
cord-015021-pol2qm74	2027	37	EC	EC	NNP
cord-015021-pol2qm74	2027	38	damage	damage	NN
cord-015021-pol2qm74	2027	39	was	be	VBD
cord-015021-pol2qm74	2027	40	also	also	RB
cord-015021-pol2qm74	2027	41	reduced	reduce	VBN
cord-015021-pol2qm74	2027	42	(	(	-LRB-
cord-015021-pol2qm74	2027	43	p<0.0005	p<0.0005	CC
cord-015021-pol2qm74	2027	44	at	at	IN
cord-015021-pol2qm74	2027	45	6	6	CD
cord-015021-pol2qm74	2027	46	retool/1	retool/1	VBN
cord-015021-pol2qm74	2027	47	ASC	ASC	NNP
cord-015021-pol2qm74	2027	48	)	)	-RRB-
cord-015021-pol2qm74	2027	49	.	.	.
cord-015021-pol2qm74	2028	1	In	in	IN
cord-015021-pol2qm74	2028	2	the	the	DT
cord-015021-pol2qm74	2028	3	in	in	IN
cord-015021-pol2qm74	2028	4	rive	rive	NNP
cord-015021-pol2qm74	2028	5	model	model	NN
cord-015021-pol2qm74	2028	6	ASC	ASC	NNP
cord-015021-pol2qm74	2028	7	increased	increase	VBD
cord-015021-pol2qm74	2028	8	the	the	DT
cord-015021-pol2qm74	2028	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2028	10	-	-	HYPH
cord-015021-pol2qm74	2028	11	induced	induce	VBN
cord-015021-pol2qm74	2028	12	blood	blood	NN
cord-015021-pol2qm74	2028	13	PMN	PMN	NNP
cord-015021-pol2qm74	2028	14	decrease	decrease	NN
cord-015021-pol2qm74	2028	15	(	(	-LRB-
cord-015021-pol2qm74	2028	16	p<0.05	p<0.05	CD
cord-015021-pol2qm74	2028	17	)	)	-RRB-
cord-015021-pol2qm74	2028	18	,	,	,
cord-015021-pol2qm74	2028	19	decreased	decrease	VBD
cord-015021-pol2qm74	2028	20	the	the	DT
cord-015021-pol2qm74	2028	21	protein	protein	NN
cord-015021-pol2qm74	2028	22	clearance	clearance	NN
cord-015021-pol2qm74	2028	23	(	(	-LRB-
cord-015021-pol2qm74	2028	24	p<0.05	p<0.05	CD
cord-015021-pol2qm74	2028	25	)	)	-RRB-
cord-015021-pol2qm74	2028	26	as	as	RB
cord-015021-pol2qm74	2028	27	well	well	RB
cord-015021-pol2qm74	2028	28	as	as	IN
cord-015021-pol2qm74	2028	29	the	the	DT
cord-015021-pol2qm74	2028	30	zymosan	zymosan	NNP
cord-015021-pol2qm74	2028	31	-	-	HYPH
cord-015021-pol2qm74	2028	32	induced	induce	VBN
cord-015021-pol2qm74	2028	33	ROM	rom	NN
cord-015021-pol2qm74	2028	34	production	production	NN
cord-015021-pol2qm74	2028	35	(	(	-LRB-
cord-015021-pol2qm74	2028	36	p<0.03	p<0.03	NN
cord-015021-pol2qm74	2028	37	)	)	-RRB-
cord-015021-pol2qm74	2028	38	,	,	,
cord-015021-pol2qm74	2028	39	indicating	indicate	VBG
cord-015021-pol2qm74	2028	40	the	the	DT
cord-015021-pol2qm74	2028	41	ASC	ASC	NNP
cord-015021-pol2qm74	2028	42	-	-	HYPH
cord-015021-pol2qm74	2028	43	mediated	mediate	VBN
cord-015021-pol2qm74	2028	44	reduction	reduction	NN
cord-015021-pol2qm74	2028	45	of	of	IN
cord-015021-pol2qm74	2028	46	adhesion	adhesion	NN
cord-015021-pol2qm74	2028	47	,	,	,
cord-015021-pol2qm74	2028	48	ROM	rom	NN
cord-015021-pol2qm74	2028	49	production	production	NN
cord-015021-pol2qm74	2028	50	and	and	CC
cord-015021-pol2qm74	2028	51	lung	lung	NN
cord-015021-pol2qm74	2028	52	tissue	tissue	NN
cord-015021-pol2qm74	2028	53	damage	damage	NN
cord-015021-pol2qm74	2028	54	processes	process	NNS
cord-015021-pol2qm74	2028	55	.	.	.
cord-015021-pol2qm74	2029	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	2029	2	.	.	.
cord-015021-pol2qm74	2030	1	By	by	IN
cord-015021-pol2qm74	2030	2	in	in	IN
cord-015021-pol2qm74	2030	3	vitro	vitro	FW
cord-015021-pol2qm74	2030	4	and	and	CC
cord-015021-pol2qm74	2030	5	in	in	IN
cord-015021-pol2qm74	2030	6	rive	rive	NNP
cord-015021-pol2qm74	2030	7	experiments	experiment	NNS
cord-015021-pol2qm74	2030	8	ascorbic	ascorbic	NN
cord-015021-pol2qm74	2030	9	acid	acid	NN
cord-015021-pol2qm74	2030	10	reduced	reduce	VBD
cord-015021-pol2qm74	2030	11	the	the	DT
cord-015021-pol2qm74	2030	12	adhesion	adhesion	NN
cord-015021-pol2qm74	2030	13	-	-	HYPH
cord-015021-pol2qm74	2030	14	and	and	CC
cord-015021-pol2qm74	2030	15	ROM	rom	NN
cord-015021-pol2qm74	2030	16	production	production	NN
cord-015021-pol2qm74	2030	17	-	-	HYPH
cord-015021-pol2qm74	2030	18	initiated	initiate	VBN
cord-015021-pol2qm74	2030	19	tissue	tissue	NN
cord-015021-pol2qm74	2030	20	damage	damage	NN
cord-015021-pol2qm74	2030	21	.	.	.
cord-015021-pol2qm74	2031	1	Therefore	therefore	RB
cord-015021-pol2qm74	2031	2	,	,	,
cord-015021-pol2qm74	2031	3	i.v	i.v	NNP
cord-015021-pol2qm74	2031	4	.	.	NNP
cord-015021-pol2qm74	2031	5	administration	administration	NN
cord-015021-pol2qm74	2031	6	of	of	IN
cord-015021-pol2qm74	2031	7	ascorbic	ascorbic	NNP
cord-015021-pol2qm74	2031	8	acid	acid	NN
cord-015021-pol2qm74	2031	9	is	be	VBZ
cord-015021-pol2qm74	2031	10	recommended	recommend	VBN
cord-015021-pol2qm74	2031	11	for	for	IN
cord-015021-pol2qm74	2031	12	oxidative	oxidative	JJ
cord-015021-pol2qm74	2031	13	stress	stress	NN
cord-015021-pol2qm74	2031	14	-	-	HYPH
cord-015021-pol2qm74	2031	15	associated	associate	VBN
cord-015021-pol2qm74	2031	16	states	state	NNS
cord-015021-pol2qm74	2031	17	after	after	IN
cord-015021-pol2qm74	2031	18	trauma	trauma	NN
cord-015021-pol2qm74	2031	19	,	,	,
cord-015021-pol2qm74	2031	20	sepsis	sepsis	NN
cord-015021-pol2qm74	2031	21	,	,	,
cord-015021-pol2qm74	2031	22	shock	shock	NN
cord-015021-pol2qm74	2031	23	and	and	CC
cord-015021-pol2qm74	2031	24	organ	organ	NN
cord-015021-pol2qm74	2031	25	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2031	26	.	.	.
cord-015021-pol2qm74	2032	1	for	for	IN
cord-015021-pol2qm74	2032	2	neut	neut	NNP
cord-015021-pol2qm74	2032	3	rophi	rophi	NNP
cord-015021-pol2qm74	2032	4	l	l	NNP
cord-015021-pol2qm74	2032	5	-	-	HYPH
cord-015021-pol2qm74	2032	6	accumulat	accumulat	NNP
cord-015021-pol2qm74	2032	7	ion	ion	NN
cord-015021-pol2qm74	2032	8	and	and	CC
cord-015021-pol2qm74	2032	9	activation	activation	NN
cord-015021-pol2qm74	2032	10	.	.	.
cord-015021-pol2qm74	2033	1	We	-PRON-	PRP
cord-015021-pol2qm74	2033	2	investigated	investigate	VBD
cord-015021-pol2qm74	2033	3	the	the	DT
cord-015021-pol2qm74	2033	4	influence	influence	NN
cord-015021-pol2qm74	2033	5	of	of	IN
cord-015021-pol2qm74	2033	6	OR	or	CC
cord-015021-pol2qm74	2033	7	to	to	IN
cord-015021-pol2qm74	2033	8	the	the	DT
cord-015021-pol2qm74	2033	9	activation	activation	NN
cord-015021-pol2qm74	2033	10	and	and	CC
cord-015021-pol2qm74	2033	11	the	the	DT
cord-015021-pol2qm74	2033	12	expression	expression	NN
cord-015021-pol2qm74	2033	13	of	of	IN
cord-015021-pol2qm74	2033	14	LECAM	LECAM	NNP
cord-015021-pol2qm74	2033	15	-	-	:
cord-015021-pol2qm74	2033	16	I	I	NNP
cord-015021-pol2qm74	2033	17	and	and	CC
cord-015021-pol2qm74	2033	18	CDIIb	CDIIb	NNS
cord-015021-pol2qm74	2033	19	,	,	,
cord-015021-pol2qm74	2033	20	CDI8	CDI8	NNP
cord-015021-pol2qm74	2033	21	on	on	IN
cord-015021-pol2qm74	2033	22	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2033	23	and	and	CC
cord-015021-pol2qm74	2033	24	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2033	25	.	.	.
cord-015021-pol2qm74	2034	1	Methods	method	NNS
cord-015021-pol2qm74	2034	2	:	:	:
cord-015021-pol2qm74	2035	1	From	from	IN
cord-015021-pol2qm74	2035	2	blood	blood	NN
cord-015021-pol2qm74	2035	3	samples	sample	NNS
cord-015021-pol2qm74	2035	4	(	(	-LRB-
cord-015021-pol2qm74	2035	5	n=5	n=5	RB
cord-015021-pol2qm74	2035	6	)	)	-RRB-
cord-015021-pol2qm74	2036	1	all	all	DT
cord-015021-pol2qm74	2036	2	white	white	JJ
cord-015021-pol2qm74	2036	3	blood	blood	NN
cord-015021-pol2qm74	2036	4	cells	cell	NNS
cord-015021-pol2qm74	2036	5	(	(	-LRB-
cord-015021-pol2qm74	2036	6	WBC	WBC	NNP
cord-015021-pol2qm74	2036	7	)	)	-RRB-
cord-015021-pol2qm74	2036	8	and	and	CC
cord-015021-pol2qm74	2036	9	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2036	10	(	(	-LRB-
cord-015021-pol2qm74	2036	11	NC	NC	NNP
cord-015021-pol2qm74	2036	12	)	)	-RRB-
cord-015021-pol2qm74	2036	13	were	be	VBD
cord-015021-pol2qm74	2036	14	isolated	isolate	VBN
cord-015021-pol2qm74	2036	15	and	and	CC
cord-015021-pol2qm74	2036	16	cultured	cultured	JJ
cord-015021-pol2qm74	2036	17	.	.	.
cord-015021-pol2qm74	2037	1	OR	or	CC
cord-015021-pol2qm74	2037	2	were	be	VBD
cord-015021-pol2qm74	2037	3	produced	produce	VBN
cord-015021-pol2qm74	2037	4	via	via	IN
cord-015021-pol2qm74	2037	5	the	the	DT
cord-015021-pol2qm74	2037	6	xanthine	xanthine	NN
cord-015021-pol2qm74	2037	7	oxidase	oxidase	NN
cord-015021-pol2qm74	2037	8	/	/	SYM
cord-015021-pol2qm74	2037	9	hypoxanthine	hypoxanthine	NN
cord-015021-pol2qm74	2037	10	system	system	NN
cord-015021-pol2qm74	2037	11	.	.	.
cord-015021-pol2qm74	2038	1	After	after	IN
cord-015021-pol2qm74	2038	2	0,5	0,5	CD
cord-015021-pol2qm74	2038	3	,	,	,
cord-015021-pol2qm74	2038	4	15,30,60	15,30,60	CD
cord-015021-pol2qm74	2038	5	and	and	CC
cord-015021-pol2qm74	2038	6	120	120	CD
cord-015021-pol2qm74	2038	7	minutes	minute	NNS
cord-015021-pol2qm74	2038	8	a	a	DT
cord-015021-pol2qm74	2038	9	Giemsa	Giemsa	NNP
cord-015021-pol2qm74	2038	10	-	-	HYPH
cord-015021-pol2qm74	2038	11	staining	staining	NN
cord-015021-pol2qm74	2038	12	to	to	TO
cord-015021-pol2qm74	2038	13	determine	determine	VB
cord-015021-pol2qm74	2038	14	the	the	DT
cord-015021-pol2qm74	2038	15	granulation	granulation	NN
cord-015021-pol2qm74	2038	16	of	of	IN
cord-015021-pol2qm74	2038	17	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2038	18	(	(	-LRB-
cord-015021-pol2qm74	2038	19	n	n	CC
cord-015021-pol2qm74	2038	20	:	:	:
cord-015021-pol2qm74	2038	21	normal	normal	JJ
cord-015021-pol2qm74	2038	22	,	,	,
cord-015021-pol2qm74	2038	23	r	r	NN
cord-015021-pol2qm74	2038	24	:	:	:
cord-015021-pol2qm74	2038	25	reduced	reduce	VBN
cord-015021-pol2qm74	2038	26	)	)	-RRB-
cord-015021-pol2qm74	2038	27	and	and	CC
cord-015021-pol2qm74	2038	28	a	a	DT
cord-015021-pol2qm74	2038	29	FACS	FACS	NNP
cord-015021-pol2qm74	2038	30	-	-	HYPH
cord-015021-pol2qm74	2038	31	analysis	analysis	NN
cord-015021-pol2qm74	2038	32	with	with	IN
cord-015021-pol2qm74	2038	33	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	2038	34	antibodies	antibody	NNS
cord-015021-pol2qm74	2038	35	detecting	detect	VBG
cord-015021-pol2qm74	2038	36	CDIIb	CDIIb	NNS
cord-015021-pol2qm74	2038	37	,	,	,
cord-015021-pol2qm74	2038	38	CDI8	CDI8	NNP
cord-015021-pol2qm74	2038	39	and	and	CC
cord-015021-pol2qm74	2038	40	LECAM	LECAM	NNP
cord-015021-pol2qm74	2038	41	-	-	:
cord-015021-pol2qm74	2038	42	I	-PRON-	PRP
cord-015021-pol2qm74	2038	43	was	be	VBD
cord-015021-pol2qm74	2038	44	performed	perform	VBN
cord-015021-pol2qm74	2038	45	.	.	.
cord-015021-pol2qm74	2039	1	Results	result	NNS
cord-015021-pol2qm74	2039	2	:	:	:
cord-015021-pol2qm74	2040	1	under	under	IN
cord-015021-pol2qm74	2040	2	the	the	DT
cord-015021-pol2qm74	2040	3	influence	influence	NN
cord-015021-pol2qm74	2040	4	of	of	IN
cord-015021-pol2qm74	2040	5	OR	or	CC
cord-015021-pol2qm74	2040	6	a	a	DT
cord-015021-pol2qm74	2040	7	degranulation	degranulation	NN
cord-015021-pol2qm74	2040	8	of	of	IN
cord-015021-pol2qm74	2040	9	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2040	10	starting	start	VBG
cord-015021-pol2qm74	2040	11	at	at	IN
cord-015021-pol2qm74	2040	12	15min	15min	NNP
cord-015021-pol2qm74	2040	13	was	be	VBD
cord-015021-pol2qm74	2040	14	observed	observe	VBN
cord-015021-pol2qm74	2040	15	in	in	IN
cord-015021-pol2qm74	2040	16	WBC	WBC	NNP
cord-015021-pol2qm74	2040	17	-	-	HYPH
cord-015021-pol2qm74	2040	18	cultures	culture	NNS
cord-015021-pol2qm74	2040	19	(	(	-LRB-
cord-015021-pol2qm74	2040	20	n	n	NN
cord-015021-pol2qm74	2040	21	/	/	SYM
cord-015021-pol2qm74	2040	22	r	r	NN
cord-015021-pol2qm74	2040	23	:	:	:
cord-015021-pol2qm74	2040	24	0min	0min	CD
cord-015021-pol2qm74	2040	25	91/9	91/9	CD
cord-015021-pol2qm74	2040	26	,	,	,
cord-015021-pol2qm74	2040	27	15min	15min	NNP
cord-015021-pol2qm74	2040	28	76/24	76/24	CD
cord-015021-pol2qm74	2040	29	,	,	,
cord-015021-pol2qm74	2040	30	30min	30min	NN
cord-015021-pol2qm74	2040	31	68/32	68/32	CD
cord-015021-pol2qm74	2040	32	,	,	,
cord-015021-pol2qm74	2040	33	60min	60min	JJ
cord-015021-pol2qm74	2040	34	52/48	52/48	CD
cord-015021-pol2qm74	2040	35	,	,	,
cord-015021-pol2qm74	2040	36	120min	120min	CD
cord-015021-pol2qm74	2040	37	49/51	49/51	CD
cord-015021-pol2qm74	2040	38	)	)	-RRB-
cord-015021-pol2qm74	2040	39	.	.	.
cord-015021-pol2qm74	2041	1	These	these	DT
cord-015021-pol2qm74	2041	2	data	datum	NNS
cord-015021-pol2qm74	2041	3	were	be	VBD
cord-015021-pol2qm74	2041	4	confirmed	confirm	VBN
cord-015021-pol2qm74	2041	5	in	in	IN
cord-015021-pol2qm74	2041	6	the	the	DT
cord-015021-pol2qm74	2041	7	dot	dot	NN
cord-015021-pol2qm74	2041	8	-	-	HYPH
cord-015021-pol2qm74	2041	9	plots	plot	NNS
cord-015021-pol2qm74	2041	10	of	of	IN
cord-015021-pol2qm74	2041	11	FACS	FACS	NNP
cord-015021-pol2qm74	2041	12	-	-	HYPH
cord-015021-pol2qm74	2041	13	analysis	analysis	NN
cord-015021-pol2qm74	2041	14	.	.	.
cord-015021-pol2qm74	2042	1	Only	only	RB
cord-015021-pol2qm74	2042	2	in	in	IN
cord-015021-pol2qm74	2042	3	WBC	WBC	NNP
cord-015021-pol2qm74	2042	4	-	-	HYPH
cord-015021-pol2qm74	2042	5	cultures	culture	NNS
cord-015021-pol2qm74	2042	6	OR	or	CC
cord-015021-pol2qm74	2042	7	induced	induce	VBD
cord-015021-pol2qm74	2042	8	a	a	DT
cord-015021-pol2qm74	2042	9	significant	significant	JJ
cord-015021-pol2qm74	2042	10	increase	increase	NN
cord-015021-pol2qm74	2042	11	of	of	IN
cord-015021-pol2qm74	2042	12	LECAM	LECAM	NNP
cord-015021-pol2qm74	2042	13	-	-	:
cord-015021-pol2qm74	2042	14	I	-PRON-	PRP
cord-015021-pol2qm74	2042	15	expression	expression	NN
cord-015021-pol2qm74	2042	16	on	on	IN
cord-015021-pol2qm74	2042	17	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2042	18	up	up	RP
cord-015021-pol2qm74	2042	19	to	to	IN
cord-015021-pol2qm74	2042	20	30min	30min	NN
cord-015021-pol2qm74	2042	21	followed	follow	VBN
cord-015021-pol2qm74	2042	22	by	by	IN
cord-015021-pol2qm74	2042	23	a	a	DT
cord-015021-pol2qm74	2042	24	decrease	decrease	NN
cord-015021-pol2qm74	2042	25	to	to	IN
cord-015021-pol2qm74	2042	26	normal	normal	JJ
cord-015021-pol2qm74	2042	27	values	value	NNS
cord-015021-pol2qm74	2042	28	at	at	IN
cord-015021-pol2qm74	2042	29	60min	60min	NN
cord-015021-pol2qm74	2042	30	.	.	.
cord-015021-pol2qm74	2043	1	LECAM	LECAM	NNP
cord-015021-pol2qm74	2043	2	-	-	:
cord-015021-pol2qm74	2043	3	I	-PRON-	PRP
cord-015021-pol2qm74	2043	4	on	on	IN
cord-015021-pol2qm74	2043	5	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2043	6	disappeared	disappear	VBD
cord-015021-pol2qm74	2043	7	totally	totally	RB
cord-015021-pol2qm74	2043	8	during	during	IN
cord-015021-pol2qm74	2043	9	the	the	DT
cord-015021-pol2qm74	2043	10	observed	observed	JJ
cord-015021-pol2qm74	2043	11	period	period	NN
cord-015021-pol2qm74	2043	12	.	.	.
cord-015021-pol2qm74	2044	1	CDllb	CDllb	NNP
cord-015021-pol2qm74	2044	2	,	,	,
cord-015021-pol2qm74	2044	3	CDl8-expression	CDl8-expression	NNP
cord-015021-pol2qm74	2044	4	was	be	VBD
cord-015021-pol2qm74	2044	5	not	not	RB
cord-015021-pol2qm74	2044	6	altered	alter	VBN
cord-015021-pol2qm74	2044	7	.	.	.
cord-015021-pol2qm74	2045	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	2045	2	:	:	:
cord-015021-pol2qm74	2046	1	Increased	increase	VBN
cord-015021-pol2qm74	2046	2	LECAM	LECAM	NNP
cord-015021-pol2qm74	2046	3	-	-	:
cord-015021-pol2qm74	2046	4	I	-PRON-	PRP
cord-015021-pol2qm74	2046	5	expression	expression	NN
cord-015021-pol2qm74	2046	6	on	on	IN
cord-015021-pol2qm74	2046	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2046	8	due	due	IN
cord-015021-pol2qm74	2046	9	to	to	IN
cord-015021-pol2qm74	2046	10	OR	or	CC
cord-015021-pol2qm74	2046	11	could	could	MD
cord-015021-pol2qm74	2046	12	enhance	enhance	VB
cord-015021-pol2qm74	2046	13	the	the	DT
cord-015021-pol2qm74	2046	14	'	'	``
cord-015021-pol2qm74	2046	15	rolling	rolling	NN
cord-015021-pol2qm74	2046	16	'	'	''
cord-015021-pol2qm74	2046	17	of	of	IN
cord-015021-pol2qm74	2046	18	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2046	19	along	along	IN
cord-015021-pol2qm74	2046	20	the	the	DT
cord-015021-pol2qm74	2046	21	endothelium	endothelium	NN
cord-015021-pol2qm74	2046	22	which	which	WDT
cord-015021-pol2qm74	2046	23	is	be	VBZ
cord-015021-pol2qm74	2046	24	a	a	DT
cord-015021-pol2qm74	2046	25	prerequisite	prerequisite	NN
cord-015021-pol2qm74	2046	26	for	for	IN
cord-015021-pol2qm74	2046	27	neutrophil	neutrophil	NN
cord-015021-pol2qm74	2046	28	sticking	sticking	NN
cord-015021-pol2qm74	2046	29	and	and	CC
cord-015021-pol2qm74	2046	30	migration	migration	NN
cord-015021-pol2qm74	2046	31	.	.	.
cord-015021-pol2qm74	2047	1	Further	further	JJ
cord-015021-pol2qm74	2047	2	OR	or	CC
cord-015021-pol2qm74	2047	3	are	be	VBP
cord-015021-pol2qm74	2047	4	able	able	JJ
cord-015021-pol2qm74	2047	5	to	to	TO
cord-015021-pol2qm74	2047	6	activate	activate	VB
cord-015021-pol2qm74	2047	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2047	8	without	without	IN
cord-015021-pol2qm74	2047	9	endothelium	endothelium	NN
cord-015021-pol2qm74	2047	10	.	.	.
cord-015021-pol2qm74	2048	1	These	these	DT
cord-015021-pol2qm74	2048	2	changes	change	NNS
cord-015021-pol2qm74	2048	3	seem	seem	VBP
cord-015021-pol2qm74	2048	4	to	to	TO
cord-015021-pol2qm74	2048	5	be	be	VB
cord-015021-pol2qm74	2048	6	mediated	mediate	VBN
cord-015021-pol2qm74	2048	7	by	by	IN
cord-015021-pol2qm74	2048	8	other	other	JJ
cord-015021-pol2qm74	2048	9	WBC	WBC	NNP
cord-015021-pol2qm74	2048	10	.	.	.
cord-015021-pol2qm74	2049	1	Introduction	introduction	NN
cord-015021-pol2qm74	2049	2	.	.	.
cord-015021-pol2qm74	2050	1	Multiple	multiple	JJ
cord-015021-pol2qm74	2050	2	Organ	Organ	NNP
cord-015021-pol2qm74	2050	3	Failure	failure	NN
cord-015021-pol2qm74	2050	4	(	(	-LRB-
cord-015021-pol2qm74	2050	5	MOF	MOF	NNP
cord-015021-pol2qm74	2050	6	)	)	-RRB-
cord-015021-pol2qm74	2050	7	has	have	VBZ
cord-015021-pol2qm74	2050	8	been	be	VBN
cord-015021-pol2qm74	2050	9	hypothesized	hypothesize	VBN
cord-015021-pol2qm74	2050	10	to	to	TO
cord-015021-pol2qm74	2050	11	be	be	VB
cord-015021-pol2qm74	2050	12	the	the	DT
cord-015021-pol2qm74	2050	13	result	result	NN
cord-015021-pol2qm74	2050	14	of	of	IN
cord-015021-pol2qm74	2050	15	an	an	DT
cord-015021-pol2qm74	2050	16	excessive	excessive	JJ
cord-015021-pol2qm74	2050	17	uncontrolled	uncontrolled	JJ
cord-015021-pol2qm74	2050	18	autedestructive	autedestructive	JJ
cord-015021-pol2qm74	2050	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2050	20	response	response	NN
cord-015021-pol2qm74	2050	21	.	.	.
cord-015021-pol2qm74	2051	1	Since	since	IN
cord-015021-pol2qm74	2051	2	the	the	DT
cord-015021-pol2qm74	2051	3	complement	complement	NN
cord-015021-pol2qm74	2051	4	system	system	NN
cord-015021-pol2qm74	2051	5	is	be	VBZ
cord-015021-pol2qm74	2051	6	an	an	DT
cord-015021-pol2qm74	2051	7	important	important	JJ
cord-015021-pol2qm74	2051	8	mediator	mediator	NN
cord-015021-pol2qm74	2051	9	and	and	CC
cord-015021-pol2qm74	2051	10	initiator	initiator	NN
cord-015021-pol2qm74	2051	11	of	of	IN
cord-015021-pol2qm74	2051	12	the	the	DT
cord-015021-pol2qm74	2051	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2051	14	response	response	NN
cord-015021-pol2qm74	2051	15	,	,	,
cord-015021-pol2qm74	2051	16	interruption	interruption	NN
cord-015021-pol2qm74	2051	17	of	of	IN
cord-015021-pol2qm74	2051	18	this	this	DT
cord-015021-pol2qm74	2051	19	cascade	cascade	NN
cord-015021-pol2qm74	2051	20	could	could	MD
cord-015021-pol2qm74	2051	21	theoretically	theoretically	RB
cord-015021-pol2qm74	2051	22	lead	lead	VB
cord-015021-pol2qm74	2051	23	to	to	IN
cord-015021-pol2qm74	2051	24	an	an	DT
cord-015021-pol2qm74	2051	25	attenuation	attenuation	NN
cord-015021-pol2qm74	2051	26	of	of	IN
cord-015021-pol2qm74	2051	27	MOF	MOF	NNP
cord-015021-pol2qm74	2051	28	.	.	.
cord-015021-pol2qm74	2052	1	In	in	IN
cord-015021-pol2qm74	2052	2	order	order	NN
cord-015021-pol2qm74	2052	3	to	to	TO
cord-015021-pol2qm74	2052	4	test	test	VB
cord-015021-pol2qm74	2052	5	this	this	DT
cord-015021-pol2qm74	2052	6	hypothesis	hypothesis	NN
cord-015021-pol2qm74	2052	7	we	-PRON-	PRP
cord-015021-pol2qm74	2052	8	evaluated	evaluate	VBD
cord-015021-pol2qm74	2052	9	the	the	DT
cord-015021-pol2qm74	2052	10	response	response	NN
cord-015021-pol2qm74	2052	11	of	of	IN
cord-015021-pol2qm74	2052	12	C5-delicient	c5-delicient	NN
cord-015021-pol2qm74	2052	13	mice	mouse	NNS
cord-015021-pol2qm74	2052	14	in	in	IN
cord-015021-pol2qm74	2052	15	a	a	DT
cord-015021-pol2qm74	2052	16	model	model	NN
cord-015021-pol2qm74	2052	17	of	of	IN
cord-015021-pol2qm74	2052	18	zymesan	zymesan	NNP
cord-015021-pol2qm74	2052	19	indt	indt	NNP
cord-015021-pol2qm74	2052	20	~	~	NFP
cord-015021-pol2qm74	2052	21	ed	ed	NNP
cord-015021-pol2qm74	2052	22	MOF	MOF	NNP
cord-015021-pol2qm74	2052	23	.	.	.
cord-015021-pol2qm74	2053	1	Materials	material	NNS
cord-015021-pol2qm74	2053	2	and	and	CC
cord-015021-pol2qm74	2053	3	Methods	method	NNS
cord-015021-pol2qm74	2053	4	.	.	.
cord-015021-pol2qm74	2054	1	25	25	CD
cord-015021-pol2qm74	2054	2	C5-deficient	c5-deficient	NN
cord-015021-pol2qm74	2054	3	B2D10	B2D10	NNP
cord-015021-pol2qm74	2054	4	/	/	SYM
cord-015021-pol2qm74	2054	5	OId	OId	NNS
cord-015021-pol2qm74	2054	6	and	and	CC
cord-015021-pol2qm74	2054	7	25	25	CD
cord-015021-pol2qm74	2054	8	C5-sufficient	c5-sufficient	NN
cord-015021-pol2qm74	2054	9	B2D10/	B2D10/	NNS
cord-015021-pol2qm74	2055	1	New	new	JJ
cord-015021-pol2qm74	2055	2	mice	mouse	NNS
cord-015021-pol2qm74	2055	3	were	be	VBD
cord-015021-pol2qm74	2055	4	used	use	VBN
cord-015021-pol2qm74	2055	5	in	in	IN
cord-015021-pol2qm74	2055	6	this	this	DT
cord-015021-pol2qm74	2055	7	study	study	NN
cord-015021-pol2qm74	2055	8	.	.	.
cord-015021-pol2qm74	2056	1	On	on	IN
cord-015021-pol2qm74	2056	2	day	day	NN
cord-015021-pol2qm74	2056	3	0	0	NFP
cord-015021-pol2qm74	2056	4	all	all	DT
cord-015021-pol2qm74	2056	5	mice	mouse	NNS
cord-015021-pol2qm74	2056	6	received	receive	VBD
cord-015021-pol2qm74	2056	7	an	an	DT
cord-015021-pol2qm74	2056	8	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	2056	9	injection	injection	NN
cord-015021-pol2qm74	2056	10	with	with	IN
cord-015021-pol2qm74	2056	11	zymosan	zymosan	NNP
cord-015021-pol2qm74	2056	12	suspended	suspend	VBN
cord-015021-pol2qm74	2056	13	in	in	IN
cord-015021-pol2qm74	2056	14	paraffin	paraffin	NN
cord-015021-pol2qm74	2056	15	in	in	IN
cord-015021-pol2qm74	2056	16	a	a	DT
cord-015021-pol2qm74	2056	17	dose	dose	NN
cord-015021-pol2qm74	2056	18	of	of	IN
cord-015021-pol2qm74	2056	19	1	1	CD
cord-015021-pol2qm74	2056	20	mg	mg	NNP
cord-015021-pol2qm74	2056	21	/	/	SYM
cord-015021-pol2qm74	2056	22	g	g	NN
cord-015021-pol2qm74	2056	23	body	body	NN
cord-015021-pol2qm74	2056	24	weight	weight	NN
cord-015021-pol2qm74	2056	25	.	.	.
cord-015021-pol2qm74	2057	1	Between	between	IN
cord-015021-pol2qm74	2057	2	day	day	NN
cord-015021-pol2qm74	2057	3	0	0	CD
cord-015021-pol2qm74	2057	4	and	and	CC
cord-015021-pol2qm74	2057	5	12	12	CD
cord-015021-pol2qm74	2057	6	,	,	,
cord-015021-pol2qm74	2057	7	biological	biological	JJ
cord-015021-pol2qm74	2057	8	parameters	parameter	NNS
cord-015021-pol2qm74	2057	9	(	(	-LRB-
cord-015021-pol2qm74	2057	10	temperature	temperature	NN
cord-015021-pol2qm74	2057	11	,	,	,
cord-015021-pol2qm74	2057	12	body	body	NN
cord-015021-pol2qm74	2057	13	weight	weight	NN
cord-015021-pol2qm74	2057	14	and	and	CC
cord-015021-pol2qm74	2057	15	clinical	clinical	JJ
cord-015021-pol2qm74	2057	16	condition	condition	NN
cord-015021-pol2qm74	2057	17	)	)	-RRB-
cord-015021-pol2qm74	2057	18	were	be	VBD
cord-015021-pol2qm74	2057	19	measured	measure	VBN
cord-015021-pol2qm74	2057	20	daily	daily	RB
cord-015021-pol2qm74	2057	21	and	and	CC
cord-015021-pol2qm74	2057	22	mortality	mortality	NN
cord-015021-pol2qm74	2057	23	was	be	VBD
cord-015021-pol2qm74	2057	24	monitored	monitor	VBN
cord-015021-pol2qm74	2057	25	.	.	.
cord-015021-pol2qm74	2058	1	Clinical	clinical	JJ
cord-015021-pol2qm74	2058	2	condition	condition	NN
cord-015021-pol2qm74	2058	3	was	be	VBD
cord-015021-pol2qm74	2058	4	assessed	assess	VBN
cord-015021-pol2qm74	2058	5	by	by	IN
cord-015021-pol2qm74	2058	6	blindly	blindly	RB
cord-015021-pol2qm74	2058	7	grading	grade	VBG
cord-015021-pol2qm74	2058	8	the	the	DT
cord-015021-pol2qm74	2058	9	degree	degree	NN
cord-015021-pol2qm74	2058	10	of	of	IN
cord-015021-pol2qm74	2058	11	lethargy	lethargy	NN
cord-015021-pol2qm74	2058	12	,	,	,
cord-015021-pol2qm74	2058	13	conjunctivitis	conjunctivitis	NN
cord-015021-pol2qm74	2058	14	,	,	,
cord-015021-pol2qm74	2058	15	diarrhea	diarrhea	NN
cord-015021-pol2qm74	2058	16	,	,	,
cord-015021-pol2qm74	2058	17	and	and	CC
cord-015021-pol2qm74	2058	18	ruffled	ruffled	JJ
cord-015021-pol2qm74	2058	19	fur	fur	NN
cord-015021-pol2qm74	2058	20	of	of	IN
cord-015021-pol2qm74	2058	21	each	each	DT
cord-015021-pol2qm74	2058	22	mouse	mouse	NN
cord-015021-pol2qm74	2058	23	on	on	IN
cord-015021-pol2qm74	2058	24	a	a	DT
cord-015021-pol2qm74	2058	25	two	two	CD
cord-015021-pol2qm74	2058	26	point	point	NN
cord-015021-pol2qm74	2058	27	scale	scale	NN
cord-015021-pol2qm74	2058	28	(	(	-LRB-
cord-015021-pol2qm74	2058	29	maximum	maximum	JJ
cord-015021-pol2qm74	2058	30	score=4	score=4	NNS
cord-015021-pol2qm74	2058	31	)	)	-RRB-
cord-015021-pol2qm74	2058	32	.	.	.
cord-015021-pol2qm74	2059	1	On	on	IN
cord-015021-pol2qm74	2059	2	day	day	NN
cord-015021-pol2qm74	2059	3	12	12	CD
cord-015021-pol2qm74	2059	4	all	all	DT
cord-015021-pol2qm74	2059	5	surviving	survive	VBG
cord-015021-pol2qm74	2059	6	mice	mouse	NNS
cord-015021-pol2qm74	2059	7	were	be	VBD
cord-015021-pol2qm74	2059	8	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	2059	9	and	and	CC
cord-015021-pol2qm74	2059	10	relative	relative	JJ
cord-015021-pol2qm74	2059	11	organ	organ	NN
cord-015021-pol2qm74	2059	12	weights	weight	NNS
cord-015021-pol2qm74	2059	13	of	of	IN
cord-015021-pol2qm74	2059	14	lungs	lung	NNS
cord-015021-pol2qm74	2059	15	,	,	,
cord-015021-pol2qm74	2059	16	liver	liver	NN
cord-015021-pol2qm74	2059	17	,	,	,
cord-015021-pol2qm74	2059	18	spleen	spleen	NN
cord-015021-pol2qm74	2059	19	and	and	CC
cord-015021-pol2qm74	2059	20	kidneys	kidney	NNS
cord-015021-pol2qm74	2059	21	(	(	-LRB-
cord-015021-pol2qm74	2059	22	relative	relative	JJ
cord-015021-pol2qm74	2059	23	organ	organ	NN
cord-015021-pol2qm74	2059	24	weight=	weight=	NN
cord-015021-pol2qm74	2059	25	(	(	-LRB-
cord-015021-pol2qm74	2059	26	organ	organ	NN
cord-015021-pol2qm74	2059	27	weight	weight	NN
cord-015021-pol2qm74	2059	28	/	/	SYM
cord-015021-pol2qm74	2059	29	body	body	NN
cord-015021-pol2qm74	2059	30	weight)x100	weight)x100	NFP
cord-015021-pol2qm74	2059	31	)	)	-RRB-
cord-015021-pol2qm74	2059	32	wore	wear	VBD
cord-015021-pol2qm74	2059	33	calculated	calculate	VBN
cord-015021-pol2qm74	2059	34	.	.	.
cord-015021-pol2qm74	2060	1	Earlier	early	JJR
cord-015021-pol2qm74	2060	2	experiments	experiment	NNS
cord-015021-pol2qm74	2060	3	with	with	IN
cord-015021-pol2qm74	2060	4	our	-PRON-	PRP$
cord-015021-pol2qm74	2060	5	model	model	NN
cord-015021-pol2qm74	2060	6	have	have	VBP
cord-015021-pol2qm74	2060	7	shown	show	VBN
cord-015021-pol2qm74	2060	8	a	a	DT
cord-015021-pol2qm74	2060	9	good	good	JJ
cord-015021-pol2qm74	2060	10	correlation	correlation	NN
cord-015021-pol2qm74	2060	11	between	between	IN
cord-015021-pol2qm74	2060	12	histological	histological	JJ
cord-015021-pol2qm74	2060	13	organ	organ	NN
cord-015021-pol2qm74	2060	14	damage	damage	NN
cord-015021-pol2qm74	2060	15	and	and	CC
cord-015021-pol2qm74	2060	16	relative	relative	JJ
cord-015021-pol2qm74	2060	17	organ	organ	NN
cord-015021-pol2qm74	2060	18	weights	weight	NNS
cord-015021-pol2qm74	2060	19	.	.	.
cord-015021-pol2qm74	2061	1	Statistical	statistical	JJ
cord-015021-pol2qm74	2061	2	analysis	analysis	NN
cord-015021-pol2qm74	2061	3	of	of	IN
cord-015021-pol2qm74	2061	4	biological	biological	JJ
cord-015021-pol2qm74	2061	5	parameter	parameter	NN
cord-015021-pol2qm74	2061	6	was	be	VBD
cord-015021-pol2qm74	2061	7	performed	perform	VBN
cord-015021-pol2qm74	2061	8	using	use	VBG
cord-015021-pol2qm74	2061	9	the	the	DT
cord-015021-pol2qm74	2061	10	Koziol	Koziol	NNP
cord-015021-pol2qm74	2061	11	curve	curve	NN
cord-015021-pol2qm74	2061	12	analysis	analysis	NN
cord-015021-pol2qm74	2061	13	.	.	.
cord-015021-pol2qm74	2062	1	Analysis	analysis	NN
cord-015021-pol2qm74	2062	2	was	be	VBD
cord-015021-pol2qm74	2062	3	divided	divide	VBN
cord-015021-pol2qm74	2062	4	in	in	IN
cord-015021-pol2qm74	2062	5	an	an	DT
cord-015021-pol2qm74	2062	6	acute	acute	JJ
cord-015021-pol2qm74	2062	7	phase	phase	NN
cord-015021-pol2qm74	2062	8	(	(	-LRB-
cord-015021-pol2qm74	2062	9	day	day	NN
cord-015021-pol2qm74	2062	10	0	0	CD
cord-015021-pol2qm74	2062	11	-	-	SYM
cord-015021-pol2qm74	2062	12	4	4	CD
cord-015021-pol2qm74	2062	13	)	)	-RRB-
cord-015021-pol2qm74	2062	14	and	and	CC
cord-015021-pol2qm74	2062	15	a	a	DT
cord-015021-pol2qm74	2062	16	late	late	JJ
cord-015021-pol2qm74	2062	17	phase	phase	NN
cord-015021-pol2qm74	2062	18	(	(	-LRB-
cord-015021-pol2qm74	2062	19	day	day	NN
cord-015021-pol2qm74	2062	20	8	8	CD
cord-015021-pol2qm74	2062	21	-	-	SYM
cord-015021-pol2qm74	2062	22	12	12	CD
cord-015021-pol2qm74	2062	23	)	)	-RRB-
cord-015021-pol2qm74	2062	24	.	.	.
cord-015021-pol2qm74	2063	1	Relative	relative	JJ
cord-015021-pol2qm74	2063	2	organ	organ	NN
cord-015021-pol2qm74	2063	3	weights	weight	NNS
cord-015021-pol2qm74	2063	4	were	be	VBD
cord-015021-pol2qm74	2063	5	analyzed	analyze	VBN
cord-015021-pol2qm74	2063	6	using	use	VBG
cord-015021-pol2qm74	2063	7	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	2063	8	's	's	POS
cord-015021-pol2qm74	2063	9	test	test	NN
cord-015021-pol2qm74	2063	10	and	and	CC
cord-015021-pol2qm74	2063	11	mortality	mortality	NN
cord-015021-pol2qm74	2063	12	rate	rate	NN
cord-015021-pol2qm74	2063	13	using	use	VBG
cord-015021-pol2qm74	2063	14	Fischor	Fischor	NNP
cord-015021-pol2qm74	2063	15	's	's	POS
cord-015021-pol2qm74	2063	16	exact	exact	JJ
cord-015021-pol2qm74	2063	17	test	test	NN
cord-015021-pol2qm74	2063	18	.	.	.
cord-015021-pol2qm74	2064	1	Results	result	NNS
cord-015021-pol2qm74	2064	2	.	.	.
cord-015021-pol2qm74	2065	1	All	all	DT
cord-015021-pol2qm74	2065	2	zymosan	zymosan	NNP
cord-015021-pol2qm74	2065	3	injected	inject	VBD
cord-015021-pol2qm74	2065	4	mice	mouse	NNS
cord-015021-pol2qm74	2066	1	showed	show	VBD
cord-015021-pol2qm74	2066	2	a	a	DT
cord-015021-pol2qm74	2066	3	typical	typical	JJ
cord-015021-pol2qm74	2066	4	triphesic	triphesic	NN
cord-015021-pol2qm74	2066	5	illness	illness	NN
cord-015021-pol2qm74	2066	6	.	.	.
cord-015021-pol2qm74	2067	1	Deterioration	deterioration	NN
cord-015021-pol2qm74	2067	2	of	of	IN
cord-015021-pol2qm74	2067	3	the	the	DT
cord-015021-pol2qm74	2067	4	clinical	clinical	JJ
cord-015021-pol2qm74	2067	5	condition	condition	NN
cord-015021-pol2qm74	2067	6	as	as	IN
cord-015021-pol2qm74	2067	7	indicated	indicate	VBN
cord-015021-pol2qm74	2067	8	by	by	IN
cord-015021-pol2qm74	2067	9	the	the	DT
cord-015021-pol2qm74	2067	10	symptom	symptom	NN
cord-015021-pol2qm74	2067	11	score	score	NN
cord-015021-pol2qm74	2067	12	and	and	CC
cord-015021-pol2qm74	2067	13	the	the	DT
cord-015021-pol2qm74	2067	14	decrease	decrease	NN
cord-015021-pol2qm74	2067	15	in	in	IN
cord-015021-pol2qm74	2067	16	temperature	temperature	NN
cord-015021-pol2qm74	2067	17	and	and	CC
cord-015021-pol2qm74	2067	18	body	body	NN
cord-015021-pol2qm74	2067	19	weight	weight	NN
cord-015021-pol2qm74	2067	20	in	in	IN
cord-015021-pol2qm74	2067	21	the	the	DT
cord-015021-pol2qm74	2067	22	acute	acute	JJ
cord-015021-pol2qm74	2067	23	phase	phase	NN
cord-015021-pol2qm74	2067	24	were	be	VBD
cord-015021-pol2qm74	2067	25	all	all	DT
cord-015021-pol2qm74	2067	26	significantly	significantly	RB
cord-015021-pol2qm74	2067	27	lass	lass	JJ
cord-015021-pol2qm74	2067	28	severe	severe	JJ
cord-015021-pol2qm74	2067	29	in	in	IN
cord-015021-pol2qm74	2067	30	C5	c5	NN
cord-015021-pol2qm74	2067	31	deficient	deficient	JJ
cord-015021-pol2qm74	2067	32	mice	mouse	NNS
cord-015021-pol2qm74	2067	33	(	(	-LRB-
cord-015021-pol2qm74	2067	34	all	all	DT
cord-015021-pol2qm74	2067	35	p<0.005	p<0.005	JJ
cord-015021-pol2qm74	2067	36	)	)	-RRB-
cord-015021-pol2qm74	2067	37	.	.	.
cord-015021-pol2qm74	2068	1	In	in	IN
cord-015021-pol2qm74	2068	2	the	the	DT
cord-015021-pol2qm74	2068	3	late	late	JJ
cord-015021-pol2qm74	2068	4	phase	phase	NN
cord-015021-pol2qm74	2068	5	no	no	DT
cord-015021-pol2qm74	2068	6	differences	difference	NNS
cord-015021-pol2qm74	2068	7	could	could	MD
cord-015021-pol2qm74	2068	8	be	be	VB
cord-015021-pol2qm74	2068	9	noticed	notice	VBN
cord-015021-pol2qm74	2068	10	in	in	IN
cord-015021-pol2qm74	2068	11	the	the	DT
cord-015021-pol2qm74	2068	12	courses	course	NNS
cord-015021-pol2qm74	2068	13	of	of	IN
cord-015021-pol2qm74	2068	14	biological	biological	JJ
cord-015021-pol2qm74	2068	15	parameters	parameter	NNS
cord-015021-pol2qm74	2068	16	.	.	.
cord-015021-pol2qm74	2069	1	Overall	overall	JJ
cord-015021-pol2qm74	2069	2	mortality	mortality	NN
cord-015021-pol2qm74	2069	3	was	be	VBD
cord-015021-pol2qm74	2069	4	2/25	2/25	CD
cord-015021-pol2qm74	2069	5	(	(	-LRB-
cord-015021-pol2qm74	2069	6	8	8	CD
cord-015021-pol2qm74	2069	7	%	%	NN
cord-015021-pol2qm74	2069	8	)	)	-RRB-
cord-015021-pol2qm74	2069	9	in	in	IN
cord-015021-pol2qm74	2069	10	C5	c5	NN
cord-015021-pol2qm74	2069	11	deficient	deficient	JJ
cord-015021-pol2qm74	2069	12	mice	mouse	NNS
cord-015021-pol2qm74	2069	13	and	and	CC
cord-015021-pol2qm74	2069	14	8/25	8/25	CD
cord-015021-pol2qm74	2069	15	(	(	-LRB-
cord-015021-pol2qm74	2069	16	32	32	CD
cord-015021-pol2qm74	2069	17	%	%	NN
cord-015021-pol2qm74	2069	18	)	)	-RRB-
cord-015021-pol2qm74	2070	1	Jn	Jn	NNP
cord-015021-pol2qm74	2070	2	C5	C5	NNP
cord-015021-pol2qm74	2070	3	sufficient	sufficient	JJ
cord-015021-pol2qm74	2070	4	mice	mouse	NNS
cord-015021-pol2qm74	2070	5	(	(	-LRB-
cord-015021-pol2qm74	2070	6	p=0.049	p=0.049	NNP
cord-015021-pol2qm74	2070	7	)	)	-RRB-
cord-015021-pol2qm74	2070	8	,	,	,
cord-015021-pol2qm74	2070	9	a	a	DT
cord-015021-pol2qm74	2070	10	difference	difference	NN
cord-015021-pol2qm74	2070	11	mainly	mainly	RB
cord-015021-pol2qm74	2070	12	due	due	IN
cord-015021-pol2qm74	2070	13	to	to	IN
cord-015021-pol2qm74	2070	14	a	a	DT
cord-015021-pol2qm74	2070	15	difference	difference	NN
cord-015021-pol2qm74	2070	16	in	in	IN
cord-015021-pol2qm74	2070	17	the	the	DT
cord-015021-pol2qm74	2070	18	acute	acute	JJ
cord-015021-pol2qm74	2070	19	phase	phase	NN
cord-015021-pol2qm74	2070	20	.	.	.
cord-015021-pol2qm74	2071	1	Organ	organ	NN
cord-015021-pol2qm74	2071	2	damage	damage	NN
cord-015021-pol2qm74	2071	3	assessed	assess	VBN
cord-015021-pol2qm74	2071	4	as	as	IN
cord-015021-pol2qm74	2071	5	the	the	DT
cord-015021-pol2qm74	2071	6	relative	relative	JJ
cord-015021-pol2qm74	2071	7	organ	organ	NN
cord-015021-pol2qm74	2071	8	weights	weight	NNS
cord-015021-pol2qm74	2071	9	did	do	VBD
cord-015021-pol2qm74	2071	10	not	not	RB
cord-015021-pol2qm74	2071	11	show	show	VB
cord-015021-pol2qm74	2071	12	any	any	DT
cord-015021-pol2qm74	2071	13	statistical	statistical	JJ
cord-015021-pol2qm74	2071	14	differences	difference	NNS
cord-015021-pol2qm74	2071	15	for	for	IN
cord-015021-pol2qm74	2071	16	any	any	DT
cord-015021-pol2qm74	2071	17	organ	organ	NN
cord-015021-pol2qm74	2071	18	between	between	IN
cord-015021-pol2qm74	2071	19	both	both	DT
cord-015021-pol2qm74	2071	20	strains	strain	NNS
cord-015021-pol2qm74	2071	21	.	.	.
cord-015021-pol2qm74	2072	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	2072	2	.	.	.
cord-015021-pol2qm74	2073	1	Complement	complement	NN
cord-015021-pol2qm74	2073	2	factor	factor	NN
cord-015021-pol2qm74	2073	3	C5	C5	NNP
cord-015021-pol2qm74	2073	4	appears	appear	VBZ
cord-015021-pol2qm74	2073	5	to	to	TO
cord-015021-pol2qm74	2073	6	play	play	VB
cord-015021-pol2qm74	2073	7	an	an	DT
cord-015021-pol2qm74	2073	8	important	important	JJ
cord-015021-pol2qm74	2073	9	role	role	NN
cord-015021-pol2qm74	2073	10	in	in	IN
cord-015021-pol2qm74	2073	11	the	the	DT
cord-015021-pol2qm74	2073	12	acute	acute	JJ
cord-015021-pol2qm74	2073	13	hyperdynamic	hyperdynamic	JJ
cord-015021-pol2qm74	2073	14	septic	septic	JJ
cord-015021-pol2qm74	2073	15	response	response	NN
cord-015021-pol2qm74	2073	16	in	in	IN
cord-015021-pol2qm74	2073	17	this	this	DT
cord-015021-pol2qm74	2073	18	model	model	NN
cord-015021-pol2qm74	2073	19	but	but	CC
cord-015021-pol2qm74	2073	20	deficiency	deficiency	NN
cord-015021-pol2qm74	2073	21	of	of	IN
cord-015021-pol2qm74	2073	22	C5	C5	NNP
cord-015021-pol2qm74	2073	23	could	could	MD
cord-015021-pol2qm74	2073	24	not	not	RB
cord-015021-pol2qm74	2073	25	prevent	prevent	VB
cord-015021-pol2qm74	2073	26	organ	organ	NN
cord-015021-pol2qm74	2073	27	damage	damage	NN
cord-015021-pol2qm74	2073	28	in	in	IN
cord-015021-pol2qm74	2073	29	the	the	DT
cord-015021-pol2qm74	2073	30	late	late	JJ
cord-015021-pol2qm74	2073	31	MOF	MOF	NNP
cord-015021-pol2qm74	2073	32	phase	phase	NN
cord-015021-pol2qm74	2073	33	.	.	.
cord-015021-pol2qm74	2074	1	This	this	DT
cord-015021-pol2qm74	2074	2	suggests	suggest	VBZ
cord-015021-pol2qm74	2074	3	that	that	IN
cord-015021-pol2qm74	2074	4	other	other	JJ
cord-015021-pol2qm74	2074	5	factors	factor	NNS
cord-015021-pol2qm74	2074	6	could	could	MD
cord-015021-pol2qm74	2074	7	be	be	VB
cord-015021-pol2qm74	2074	8	more	more	RBR
cord-015021-pol2qm74	2074	9	important	important	JJ
cord-015021-pol2qm74	2074	10	in	in	IN
cord-015021-pol2qm74	2074	11	the	the	DT
cord-015021-pol2qm74	2074	12	development	development	NN
cord-015021-pol2qm74	2074	13	of	of	IN
cord-015021-pol2qm74	2074	14	the	the	DT
cord-015021-pol2qm74	2074	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2074	16	response	response	NN
cord-015021-pol2qm74	2074	17	leading	lead	VBG
cord-015021-pol2qm74	2074	18	to	to	IN
cord-015021-pol2qm74	2074	19	MOF	MOF	NNP
cord-015021-pol2qm74	2074	20	.	.	.
cord-015021-pol2qm74	2075	1	Proinflammatory	proinflammatory	NN
cord-015021-pol2qm74	2075	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	2075	3	are	be	VBP
cord-015021-pol2qm74	2075	4	thought	think	VBN
cord-015021-pol2qm74	2075	5	to	to	TO
cord-015021-pol2qm74	2075	6	play	play	VB
cord-015021-pol2qm74	2075	7	a	a	DT
cord-015021-pol2qm74	2075	8	critical	critical	JJ
cord-015021-pol2qm74	2075	9	role	role	NN
cord-015021-pol2qm74	2075	10	in	in	IN
cord-015021-pol2qm74	2075	11	the	the	DT
cord-015021-pol2qm74	2075	12	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	2075	13	of	of	IN
cord-015021-pol2qm74	2075	14	Multiple	Multiple	NNP
cord-015021-pol2qm74	2075	15	Organ	Organ	NNP
cord-015021-pol2qm74	2075	16	Failure	Failure	NNP
cord-015021-pol2qm74	2075	17	(	(	-LRB-
cord-015021-pol2qm74	2075	18	MOF	MOF	NNP
cord-015021-pol2qm74	2075	19	)	)	-RRB-
cord-015021-pol2qm74	2075	20	.	.	.
cord-015021-pol2qm74	2076	1	In	in	IN
cord-015021-pol2qm74	2076	2	mice	mouse	NNS
cord-015021-pol2qm74	2076	3	,	,	,
cord-015021-pol2qm74	2076	4	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	2076	5	-	-	HYPH
cord-015021-pol2qm74	2076	6	lnduced	lnduce	VBN
cord-015021-pol2qm74	2076	7	Generalized	Generalized	NNP
cord-015021-pol2qm74	2076	8	Inflammation	Inflammation	NNP
cord-015021-pol2qm74	2076	9	(	(	-LRB-
cord-015021-pol2qm74	2076	10	ZtGI	ZtGI	NNP
cord-015021-pol2qm74	2076	11	)	)	-RRB-
cord-015021-pol2qm74	2076	12	leads	lead	VBZ
cord-015021-pol2qm74	2076	13	to	to	IN
cord-015021-pol2qm74	2076	14	MOF	MOF	NNP
cord-015021-pol2qm74	2076	15	.	.	.
cord-015021-pol2qm74	2077	1	Therefore	therefore	RB
cord-015021-pol2qm74	2077	2	we	-PRON-	PRP
cord-015021-pol2qm74	2077	3	performed	perform	VBD
cord-015021-pol2qm74	2077	4	a	a	DT
cord-015021-pol2qm74	2077	5	sequential	sequential	JJ
cord-015021-pol2qm74	2077	6	study	study	NN
cord-015021-pol2qm74	2077	7	into	into	IN
cord-015021-pol2qm74	2077	8	plasma	plasma	NN
cord-015021-pol2qm74	2077	9	levels	level	NNS
cord-015021-pol2qm74	2077	10	of	of	IN
cord-015021-pol2qm74	2077	11	,	,	,
cord-015021-pol2qm74	2077	12	and	and	CC
cord-015021-pol2qm74	2077	13	macrophage	macrophage	NN
cord-015021-pol2qm74	2077	14	production	production	NN
cord-015021-pol2qm74	2077	15	capacity	capacity	NN
cord-015021-pol2qm74	2077	16	for	for	IN
cord-015021-pol2qm74	2077	17	,	,	,
cord-015021-pol2qm74	2077	18	four	four	CD
cord-015021-pol2qm74	2077	19	cytokines	cytokine	NNS
cord-015021-pol2qm74	2077	20	during	during	IN
cord-015021-pol2qm74	2077	21	the	the	DT
cord-015021-pol2qm74	2077	22	development	development	NN
cord-015021-pol2qm74	2077	23	of	of	IN
cord-015021-pol2qm74	2077	24	MOF	MOF	NNP
cord-015021-pol2qm74	2077	25	in	in	IN
cord-015021-pol2qm74	2077	26	the	the	DT
cord-015021-pol2qm74	2077	27	ZIGI	ZIGI	NNP
cord-015021-pol2qm74	2077	28	model	model	NN
cord-015021-pol2qm74	2077	29	.	.	.
cord-015021-pol2qm74	2078	1	Male	male	JJ
cord-015021-pol2qm74	2078	2	young	young	JJ
cord-015021-pol2qm74	2078	3	-	-	HYPH
cord-015021-pol2qm74	2078	4	adult	adult	NN
cord-015021-pol2qm74	2078	5	C57BL/6	C57BL/6	NNP
cord-015021-pol2qm74	2078	6	mice	mouse	NNS
cord-015021-pol2qm74	2078	7	received	receive	VBD
cord-015021-pol2qm74	2078	8	zymosan	zymosan	NNP
cord-015021-pol2qm74	2078	9	(	(	-LRB-
cord-015021-pol2qm74	2078	10	1	1	CD
cord-015021-pol2qm74	2078	11	mg	mg	NNP
cord-015021-pol2qm74	2078	12	/	/	SYM
cord-015021-pol2qm74	2078	13	g	g	NN
cord-015021-pol2qm74	2078	14	body	body	NN
cord-015021-pol2qm74	2078	15	weight	weight	NN
cord-015021-pol2qm74	2078	16	)	)	-RRB-
cord-015021-pol2qm74	2078	17	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	2078	18	.	.	.
cord-015021-pol2qm74	2079	1	Groups	group	NNS
cord-015021-pol2qm74	2079	2	of	of	IN
cord-015021-pol2qm74	2079	3	14	14	CD
cord-015021-pol2qm74	2079	4	animals	animal	NNS
cord-015021-pol2qm74	2079	5	were	be	VBD
cord-015021-pol2qm74	2079	6	killed	kill	VBN
cord-015021-pol2qm74	2079	7	after	after	IN
cord-015021-pol2qm74	2079	8	3	3	CD
cord-015021-pol2qm74	2079	9	,	,	,
cord-015021-pol2qm74	2079	10	6	6	CD
cord-015021-pol2qm74	2079	11	,	,	,
cord-015021-pol2qm74	2079	12	8	8	CD
cord-015021-pol2qm74	2079	13	,	,	,
cord-015021-pol2qm74	2079	14	18	18	CD
cord-015021-pol2qm74	2079	15	and	and	CC
cord-015021-pol2qm74	2079	16	24h	24h	NNS
cord-015021-pol2qm74	2079	17	and	and	CC
cord-015021-pol2qm74	2079	18	subsequently	subsequently	RB
cord-015021-pol2qm74	2079	19	at	at	IN
cord-015021-pol2qm74	2079	20	each	each	DT
cord-015021-pol2qm74	2079	21	day	day	NN
cord-015021-pol2qm74	2079	22	until	until	IN
cord-015021-pol2qm74	2079	23	day	day	NN
cord-015021-pol2qm74	2079	24	12	12	CD
cord-015021-pol2qm74	2079	25	.	.	.
cord-015021-pol2qm74	2080	1	Plasma	plasma	NN
cord-015021-pol2qm74	2080	2	was	be	VBD
cord-015021-pol2qm74	2080	3	collected	collect	VBN
cord-015021-pol2qm74	2080	4	and	and	CC
cord-015021-pol2qm74	2080	5	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	2080	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	2080	7	were	be	VBD
cord-015021-pol2qm74	2080	8	isolated	isolate	VBN
cord-015021-pol2qm74	2080	9	and	and	CC
cord-015021-pol2qm74	2080	10	cultured	cultured	JJ
cord-015021-pol2qm74	2080	11	overnight	overnight	RB
cord-015021-pol2qm74	2080	12	with	with	IN
cord-015021-pol2qm74	2080	13	or	or	CC
cord-015021-pol2qm74	2080	14	without	without	IN
cord-015021-pol2qm74	2080	15	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	2080	16	(	(	-LRB-
cord-015021-pol2qm74	2080	17	LPS	LPS	NNP
cord-015021-pol2qm74	2080	18	)	)	-RRB-
cord-015021-pol2qm74	2080	19	.	.	.
cord-015021-pol2qm74	2081	1	Interleukin	interleukin	NN
cord-015021-pol2qm74	2081	2	1-ct	1-ct	CD
cord-015021-pol2qm74	2081	3	,	,	,
cord-015021-pol2qm74	2081	4	and	and	CC
cord-015021-pol2qm74	2081	5	-6	-6	NNP
cord-015021-pol2qm74	2082	1	(	(	-LRB-
cord-015021-pol2qm74	2082	2	IL	IL	NNP
cord-015021-pol2qm74	2082	3	-	-	HYPH
cord-015021-pol2qm74	2082	4	lc~,~	lc~,~	NNP
cord-015021-pol2qm74	2082	5	,	,	,
cord-015021-pol2qm74	2082	6	)	)	-RRB-
cord-015021-pol2qm74	2082	7	,	,	,
cord-015021-pol2qm74	2082	8	and	and	CC
cord-015021-pol2qm74	2082	9	tumour	tumour	NN
cord-015021-pol2qm74	2082	10	necrosis	necrosis	NN
cord-015021-pol2qm74	2082	11	factor	factor	NN
cord-015021-pol2qm74	2082	12	-	-	HYPH
cord-015021-pol2qm74	2082	13	o~	o~	XX
cord-015021-pol2qm74	2083	1	(	(	-LRB-
cord-015021-pol2qm74	2083	2	TNF	TNF	NNP
cord-015021-pol2qm74	2083	3	-	-	HYPH
cord-015021-pol2qm74	2083	4	c	c	NNP
cord-015021-pol2qm74	2083	5	0	0	CD
cord-015021-pol2qm74	2083	6	were	be	VBD
cord-015021-pol2qm74	2083	7	measured	measure	VBN
cord-015021-pol2qm74	2083	8	in	in	IN
cord-015021-pol2qm74	2083	9	plasma	plasma	NN
cord-015021-pol2qm74	2083	10	and	and	CC
cord-015021-pol2qm74	2083	11	culture	culture	NN
cord-015021-pol2qm74	2083	12	fluid	fluid	NN
cord-015021-pol2qm74	2083	13	by	by	IN
cord-015021-pol2qm74	2083	14	means	mean	NNS
cord-015021-pol2qm74	2083	15	of	of	IN
cord-015021-pol2qm74	2083	16	a	a	DT
cord-015021-pol2qm74	2083	17	RIA	RIA	NNP
cord-015021-pol2qm74	2083	18	(	(	-LRB-
cord-015021-pol2qm74	2083	19	detection	detection	NN
cord-015021-pol2qm74	2083	20	limit	limit	NN
cord-015021-pol2qm74	2083	21	0.1	0.1	CD
cord-015021-pol2qm74	2083	22	ng	ng	NN
cord-015021-pol2qm74	2083	23	/	/	SYM
cord-015021-pol2qm74	2083	24	ml	ml	NN
cord-015021-pol2qm74	2083	25	)	)	-RRB-
cord-015021-pol2qm74	2083	26	.	.	.
cord-015021-pol2qm74	2084	1	Interleukin-6	Interleukin-6	NNP
cord-015021-pol2qm74	2084	2	(	(	-LRB-
cord-015021-pol2qm74	2084	3	IL~	IL~	NNP
cord-015021-pol2qm74	2084	4	)	)	-RRB-
cord-015021-pol2qm74	2084	5	levels	level	NNS
cord-015021-pol2qm74	2084	6	were	be	VBD
cord-015021-pol2qm74	2084	7	assayed	assay	VBN
cord-015021-pol2qm74	2084	8	using	use	VBG
cord-015021-pol2qm74	2084	9	the	the	DT
cord-015021-pol2qm74	2084	10	B9	B9	NNP
cord-015021-pol2qm74	2084	11	hybddoma	hybddoma	NNP
cord-015021-pol2qm74	2084	12	cell	cell	NN
cord-015021-pol2qm74	2084	13	proliferation	proliferation	NN
cord-015021-pol2qm74	2084	14	assay	assay	NN
cord-015021-pol2qm74	2084	15	.	.	.
cord-015021-pol2qm74	2085	1	Zymosan	Zymosan	NNP
cord-015021-pol2qm74	2085	2	induces	induce	VBZ
cord-015021-pol2qm74	2085	3	a	a	DT
cord-015021-pol2qm74	2085	4	three	three	CD
cord-015021-pol2qm74	2085	5	-	-	HYPH
cord-015021-pol2qm74	2085	6	phase	phase	NN
cord-015021-pol2qm74	2085	7	disease	disease	NN
cord-015021-pol2qm74	2085	8	in	in	IN
cord-015021-pol2qm74	2085	9	mice	mouse	NNS
cord-015021-pol2qm74	2085	10	.	.	.
cord-015021-pol2qm74	2086	1	After	after	IN
cord-015021-pol2qm74	2086	2	an	an	DT
cord-015021-pol2qm74	2086	3	acute	acute	JJ
cord-015021-pol2qm74	2086	4	phase	phase	NN
cord-015021-pol2qm74	2086	5	the	the	DT
cord-015021-pol2qm74	2086	6	animals	animal	NNS
cord-015021-pol2qm74	2086	7	recover	recover	VBP
cord-015021-pol2qm74	2086	8	.	.	.
cord-015021-pol2qm74	2087	1	Around	around	IN
cord-015021-pol2qm74	2087	2	day	day	NN
cord-015021-pol2qm74	2087	3	7	7	CD
cord-015021-pol2qm74	2087	4	,	,	,
cord-015021-pol2qm74	2087	5	they	-PRON-	PRP
cord-015021-pol2qm74	2087	6	start	start	VBP
cord-015021-pol2qm74	2087	7	to	to	TO
cord-015021-pol2qm74	2087	8	develop	develop	VB
cord-015021-pol2qm74	2087	9	clinical	clinical	JJ
cord-015021-pol2qm74	2087	10	signs	sign	NNS
cord-015021-pol2qm74	2087	11	which	which	WDT
cord-015021-pol2qm74	2087	12	resemble	resemble	VBP
cord-015021-pol2qm74	2087	13	MOF	MOF	NNP
cord-015021-pol2qm74	2087	14	.	.	.
cord-015021-pol2qm74	2088	1	Plasma	plasma	NN
cord-015021-pol2qm74	2088	2	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	2088	3	peaked	peak	VBD
cord-015021-pol2qm74	2088	4	within	within	IN
cord-015021-pol2qm74	2088	5	3h	3h	CD
cord-015021-pol2qm74	2088	6	after	after	IN
cord-015021-pol2qm74	2088	7	zymosan	zymosan	NNP
cord-015021-pol2qm74	2088	8	injection	injection	NNP
cord-015021-pol2qm74	2088	9	and	and	CC
cord-015021-pol2qm74	2088	10	disappeared	disappear	VBD
cord-015021-pol2qm74	2088	11	within	within	IN
cord-015021-pol2qm74	2088	12	8h	8h	CD
cord-015021-pol2qm74	2088	13	.	.	.
cord-015021-pol2qm74	2089	1	From	from	IN
cord-015021-pol2qm74	2089	2	day	day	NN
cord-015021-pol2qm74	2089	3	8	8	CD
cord-015021-pol2qm74	2089	4	onwards	onwards	RB
cord-015021-pol2qm74	2089	5	,	,	,
cord-015021-pol2qm74	2089	6	TNF	TNF	NNP
cord-015021-pol2qm74	2089	7	levels	level	NNS
cord-015021-pol2qm74	2089	8	started	start	VBD
cord-015021-pol2qm74	2089	9	to	to	TO
cord-015021-pol2qm74	2089	10	rise	rise	VB
cord-015021-pol2qm74	2089	11	again	again	RB
cord-015021-pol2qm74	2089	12	.	.	.
cord-015021-pol2qm74	2090	1	Plasma	Plasma	NNP
cord-015021-pol2qm74	2090	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	2090	3	behaved	behave	VBD
cord-015021-pol2qm74	2090	4	almost	almost	RB
cord-015021-pol2qm74	2090	5	similarly	similarly	RB
cord-015021-pol2qm74	2090	6	in	in	IN
cord-015021-pol2qm74	2090	7	the	the	DT
cord-015021-pol2qm74	2090	8	acute	acute	JJ
cord-015021-pol2qm74	2090	9	phase	phase	NN
cord-015021-pol2qm74	2090	10	,	,	,
cord-015021-pol2qm74	2090	11	but	but	CC
cord-015021-pol2qm74	2090	12	in	in	IN
cord-015021-pol2qm74	2090	13	the	the	DT
cord-015021-pol2qm74	2090	14	MOF	MOF	NNP
cord-015021-pol2qm74	2090	15	phase	phase	NN
cord-015021-pol2qm74	2090	16	plasma	plasma	NN
cord-015021-pol2qm74	2090	17	IL-6	IL-6	NNP
cord-015021-pol2qm74	2090	18	remained	remain	VBD
cord-015021-pol2qm74	2090	19	low	low	JJ
cord-015021-pol2qm74	2090	20	.	.	.
cord-015021-pol2qm74	2091	1	No	no	DT
cord-015021-pol2qm74	2091	2	circulating	circulate	VBG
cord-015021-pol2qm74	2091	3	IL-16	IL-16	NNP
cord-015021-pol2qm74	2091	4	could	could	MD
cord-015021-pol2qm74	2091	5	be	be	VB
cord-015021-pol2qm74	2091	6	detected	detect	VBN
cord-015021-pol2qm74	2091	7	at	at	IN
cord-015021-pol2qm74	2091	8	any	any	DT
cord-015021-pol2qm74	2091	9	time	time	NN
cord-015021-pol2qm74	2091	10	point	point	NN
cord-015021-pol2qm74	2091	11	.	.	.
cord-015021-pol2qm74	2092	1	Macrophage	macrophage	NN
cord-015021-pol2qm74	2092	2	LPS	LPS	NNP
cord-015021-pol2qm74	2092	3	-	-	HYPH
cord-015021-pol2qm74	2092	4	stimulated	stimulate	VBN
cord-015021-pol2qm74	2092	5	production	production	NN
cord-015021-pol2qm74	2092	6	of	of	IN
cord-015021-pol2qm74	2092	7	IL	IL	NNP
cord-015021-pol2qm74	2092	8	-	-	HYPH
cord-015021-pol2qm74	2092	9	lcq	lcq	NNP
cord-015021-pol2qm74	2092	10	IL-11~	IL-11~	NNP
cord-015021-pol2qm74	2092	11	and	and	CC
cord-015021-pol2qm74	2092	12	TNF	TNF	NNP
cord-015021-pol2qm74	2092	13	--	--	:
cord-015021-pol2qm74	2092	14	c~	c~	NNP
cord-015021-pol2qm74	2092	15	was	be	VBD
cord-015021-pol2qm74	2092	16	suppressed	suppress	VBN
cord-015021-pol2qm74	2092	17	immediately	immediately	RB
cord-015021-pol2qm74	2092	18	after	after	IN
cord-015021-pol2qm74	2092	19	zymosan	zymosan	NNP
cord-015021-pol2qm74	2092	20	injection	injection	NN
cord-015021-pol2qm74	2092	21	.	.	.
cord-015021-pol2qm74	2093	1	Production	production	NN
cord-015021-pol2qm74	2093	2	of	of	IN
cord-015021-pol2qm74	2093	3	IL-16	IL-16	NNP
cord-015021-pol2qm74	2093	4	and	and	CC
cord-015021-pol2qm74	2093	5	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	2093	6	was	be	VBD
cord-015021-pol2qm74	2093	7	normalized	normalize	VBN
cord-015021-pol2qm74	2093	8	within	within	IN
cord-015021-pol2qm74	2093	9	6h	6h	CD
cord-015021-pol2qm74	2093	10	,	,	,
cord-015021-pol2qm74	2093	11	while	while	IN
cord-015021-pol2qm74	2093	12	production	production	NN
cord-015021-pol2qm74	2093	13	of	of	IN
cord-015021-pol2qm74	2093	14	IL	IL	NNP
cord-015021-pol2qm74	2093	15	-	-	HYPH
cord-015021-pol2qm74	2093	16	lc~	lc~	NNP
cord-015021-pol2qm74	2093	17	remained	remain	VBD
cord-015021-pol2qm74	2093	18	lower	low	JJR
cord-015021-pol2qm74	2093	19	than	than	IN
cord-015021-pol2qm74	2093	20	that	that	DT
cord-015021-pol2qm74	2093	21	in	in	IN
cord-015021-pol2qm74	2093	22	macrophages	macrophage	NNS
cord-015021-pol2qm74	2093	23	from	from	IN
cord-015021-pol2qm74	2093	24	untreated	untreated	JJ
cord-015021-pol2qm74	2093	25	control	control	NN
cord-015021-pol2qm74	2093	26	mice	mouse	NNS
cord-015021-pol2qm74	2093	27	.	.	.
cord-015021-pol2qm74	2094	1	Only	only	RB
cord-015021-pol2qm74	2094	2	at	at	IN
cord-015021-pol2qm74	2094	3	day	day	NN
cord-015021-pol2qm74	2094	4	6	6	CD
cord-015021-pol2qm74	2094	5	did	do	VBD
cord-015021-pol2qm74	2094	6	production	production	NN
cord-015021-pol2qm74	2094	7	of	of	IN
cord-015021-pol2qm74	2094	8	IL	IL	NNP
cord-015021-pol2qm74	2094	9	-	-	HYPH
cord-015021-pol2qm74	2094	10	I~	I~	NNP
cord-015021-pol2qm74	2094	11	reach	reach	VB
cord-015021-pol2qm74	2094	12	control	control	NN
cord-015021-pol2qm74	2094	13	values	value	NNS
cord-015021-pol2qm74	2094	14	.	.	.
cord-015021-pol2qm74	2095	1	IL-16	IL-16	NNP
cord-015021-pol2qm74	2095	2	production	production	NN
cord-015021-pol2qm74	2095	3	was	be	VBD
cord-015021-pol2qm74	2095	4	higher	high	JJR
cord-015021-pol2qm74	2095	5	than	than	IN
cord-015021-pol2qm74	2095	6	control	control	NN
cord-015021-pol2qm74	2095	7	values	value	NNS
cord-015021-pol2qm74	2095	8	from	from	IN
cord-015021-pol2qm74	2095	9	day	day	NN
cord-015021-pol2qm74	2095	10	3	3	CD
cord-015021-pol2qm74	2095	11	onwards	onwards	RB
cord-015021-pol2qm74	2095	12	.	.	.
cord-015021-pol2qm74	2096	1	IL6	il6	NN
cord-015021-pol2qm74	2096	2	production	production	NN
cord-015021-pol2qm74	2096	3	was	be	VBD
cord-015021-pol2qm74	2096	4	similar	similar	JJ
cord-015021-pol2qm74	2096	5	to	to	IN
cord-015021-pol2qm74	2096	6	that	that	DT
cord-015021-pol2qm74	2096	7	of	of	IN
cord-015021-pol2qm74	2096	8	ILI	ILI	NNP
cord-015021-pol2qm74	2096	9	-	-	HYPH
cord-015021-pol2qm74	2096	10	IL	IL	NNP
cord-015021-pol2qm74	2097	1	The	the	DT
cord-015021-pol2qm74	2097	2	production	production	NN
cord-015021-pol2qm74	2097	3	of	of	IN
cord-015021-pol2qm74	2097	4	TNF	TNF	NNP
cord-015021-pol2qm74	2097	5	-	-	HYPH
cord-015021-pol2qm74	2097	6	ct	ct	NNP
cord-015021-pol2qm74	2097	7	was	be	VBD
cord-015021-pol2qm74	2097	8	strongly	strongly	RB
cord-015021-pol2qm74	2097	9	elevated	elevate	VBN
cord-015021-pol2qm74	2097	10	between	between	IN
cord-015021-pol2qm74	2097	11	days	day	NNS
cord-015021-pol2qm74	2097	12	1	1	CD
cord-015021-pol2qm74	2097	13	and	and	CC
cord-015021-pol2qm74	2097	14	6	6	CD
cord-015021-pol2qm74	2097	15	and	and	CC
cord-015021-pol2qm74	2097	16	again	again	RB
cord-015021-pol2qm74	2097	17	during	during	IN
cord-015021-pol2qm74	2097	18	days	day	NNS
cord-015021-pol2qm74	2097	19	10	10	CD
cord-015021-pol2qm74	2097	20	to	to	TO
cord-015021-pol2qm74	2097	21	12	12	CD
cord-015021-pol2qm74	2097	22	.	.	.
cord-015021-pol2qm74	2098	1	The	the	DT
cord-015021-pol2qm74	2098	2	development	development	NN
cord-015021-pol2qm74	2098	3	of	of	IN
cord-015021-pol2qm74	2098	4	MOF	MOF	NNP
cord-015021-pol2qm74	2098	5	-	-	HYPH
cord-015021-pol2qm74	2098	6	like	like	JJ
cord-015021-pol2qm74	2098	7	symptoms	symptom	NNS
cord-015021-pol2qm74	2098	8	during	during	IN
cord-015021-pol2qm74	2098	9	ZlGI	ZlGI	NNP
cord-015021-pol2qm74	2098	10	in	in	IN
cord-015021-pol2qm74	2098	11	mice	mouse	NNS
cord-015021-pol2qm74	2098	12	is	be	VBZ
cord-015021-pol2qm74	2098	13	accompanied	accompany	VBN
cord-015021-pol2qm74	2098	14	by	by	IN
cord-015021-pol2qm74	2098	15	increased	increase	VBN
cord-015021-pol2qm74	2098	16	plasma	plasma	NN
cord-015021-pol2qm74	2098	17	levels	level	NNS
cord-015021-pol2qm74	2098	18	of	of	IN
cord-015021-pol2qm74	2098	19	TNF	TNF	NNP
cord-015021-pol2qm74	2098	20	-	-	HYPH
cord-015021-pol2qm74	2098	21	ct	ct	NNP
cord-015021-pol2qm74	2098	22	without	without	IN
cord-015021-pol2qm74	2098	23	enhanced	enhance	VBN
cord-015021-pol2qm74	2098	24	IL-16	IL-16	NNP
cord-015021-pol2qm74	2098	25	or	or	CC
cord-015021-pol2qm74	2098	26	IL-6	IL-6	NNP
cord-015021-pol2qm74	2098	27	.	.	.
cord-015021-pol2qm74	2099	1	Also	also	RB
cord-015021-pol2qm74	2099	2	,	,	,
cord-015021-pol2qm74	2099	3	the	the	DT
cord-015021-pol2qm74	2099	4	ability	ability	NN
cord-015021-pol2qm74	2099	5	of	of	IN
cord-015021-pol2qm74	2099	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	2099	7	to	to	TO
cord-015021-pol2qm74	2099	8	produce	produce	VB
cord-015021-pol2qm74	2099	9	excessive	excessive	JJ
cord-015021-pol2qm74	2099	10	amounts	amount	NNS
cord-015021-pol2qm74	2099	11	of	of	IN
cord-015021-pol2qm74	2099	12	IL-16	IL-16	NNP
cord-015021-pol2qm74	2099	13	and	and	CC
cord-015021-pol2qm74	2099	14	TNF--~	TNF--~	NNP
cord-015021-pol2qm74	2099	15	,	,	,
cord-015021-pol2qm74	2099	16	as	as	RB
cord-015021-pol2qm74	2099	17	well	well	RB
cord-015021-pol2qm74	2099	18	as	as	IN
cord-015021-pol2qm74	2099	19	the	the	DT
cord-015021-pol2qm74	2099	20	suppressed	suppress	VBN
cord-015021-pol2qm74	2099	21	capacity	capacity	NN
cord-015021-pol2qm74	2099	22	to	to	TO
cord-015021-pol2qm74	2099	23	produce	produce	VB
cord-015021-pol2qm74	2099	24	IL	IL	NNP
cord-015021-pol2qm74	2099	25	-	-	HYPH
cord-015021-pol2qm74	2099	26	lcq	lcq	NN
cord-015021-pol2qm74	2099	27	could	could	MD
cord-015021-pol2qm74	2099	28	be	be	VB
cord-015021-pol2qm74	2099	29	important	important	JJ
cord-015021-pol2qm74	2099	30	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2099	31	in	in	IN
cord-015021-pol2qm74	2099	32	the	the	DT
cord-015021-pol2qm74	2099	33	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	2099	34	of	of	IN
cord-015021-pol2qm74	2099	35	MOF	MOF	NNP
cord-015021-pol2qm74	2099	36	.	.	.
cord-015021-pol2qm74	2100	1	When	when	WRB
cord-015021-pol2qm74	2100	2	conjugated	conjugate	VBN
cord-015021-pol2qm74	2100	3	to	to	IN
cord-015021-pol2qm74	2100	4	an	an	DT
cord-015021-pol2qm74	2100	5	asialoglycoprotein	asialoglycoprotein	NN
cord-015021-pol2qm74	2100	6	,	,	,
cord-015021-pol2qm74	2100	7	DNA	dna	NN
cord-015021-pol2qm74	2100	8	and	and	CC
cord-015021-pol2qm74	2100	9	oligonucleotides	oligonucleotide	NNS
cord-015021-pol2qm74	2100	10	are	be	VBP
cord-015021-pol2qm74	2100	11	specifically	specifically	RB
cord-015021-pol2qm74	2100	12	taken	take	VBN
cord-015021-pol2qm74	2100	13	up	up	RP
cord-015021-pol2qm74	2100	14	by	by	IN
cord-015021-pol2qm74	2100	15	the	the	DT
cord-015021-pol2qm74	2100	16	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	2100	17	via	via	IN
cord-015021-pol2qm74	2100	18	the	the	DT
cord-015021-pol2qm74	2100	19	asialoglyccprotein	asialoglyccprotein	NNP
cord-015021-pol2qm74	2100	20	receptor	receptor	NN
cord-015021-pol2qm74	2100	21	which	which	WDT
cord-015021-pol2qm74	2100	22	is	be	VBZ
cord-015021-pol2qm74	2100	23	unique	unique	JJ
cord-015021-pol2qm74	2100	24	to	to	IN
cord-015021-pol2qm74	2100	25	the	the	DT
cord-015021-pol2qm74	2100	26	liver	liver	NN
cord-015021-pol2qm74	2100	27	.	.	.
cord-015021-pol2qm74	2101	1	Human	human	JJ
cord-015021-pol2qm74	2101	2	asialoglycoprotein	asialoglycoprotein	NNP
cord-015021-pol2qm74	2101	3	(	(	-LRB-
cord-015021-pol2qm74	2101	4	~1-acid	~1-acid	NNP
cord-015021-pol2qm74	2101	5	,	,	,
cord-015021-pol2qm74	2101	6	ASGP	ASGP	NNP
cord-015021-pol2qm74	2101	7	)	)	-RRB-
cord-015021-pol2qm74	2101	8	was	be	VBD
cord-015021-pol2qm74	2101	9	derivatized	derivatize	VBN
cord-015021-pol2qm74	2101	10	with	with	IN
cord-015021-pol2qm74	2101	11	low	low	JJ
cord-015021-pol2qm74	2101	12	molecular	molecular	JJ
cord-015021-pol2qm74	2101	13	weight	weight	NN
cord-015021-pol2qm74	2101	14	poly(L)lysine(PLL	poly(L)lysine(PLL	NNP
cord-015021-pol2qm74	2101	15	)	)	-RRB-
cord-015021-pol2qm74	2101	16	and	and	CC
cord-015021-pol2qm74	2101	17	complexed	complexe	VBN
cord-015021-pol2qm74	2101	18	with	with	IN
cord-015021-pol2qm74	2101	19	5	5	CD
cord-015021-pol2qm74	2101	20	antisense	antisense	NN
cord-015021-pol2qm74	2101	21	DNA	DNA	NNP
cord-015021-pol2qm74	2101	22	's	's	POS
cord-015021-pol2qm74	2101	23	(	(	-LRB-
cord-015021-pol2qm74	2101	24	AS	AS	NNP
cord-015021-pol2qm74	2101	25	)	)	-RRB-
cord-015021-pol2qm74	2101	26	complementary	complementary	JJ
cord-015021-pol2qm74	2101	27	to	to	IN
cord-015021-pol2qm74	2101	28	the	the	DT
cord-015021-pol2qm74	2101	29	5	5	CD
cord-015021-pol2qm74	2101	30	'	'	POS
cord-015021-pol2qm74	2101	31	region	region	NN
cord-015021-pol2qm74	2101	32	of	of	IN
cord-015021-pol2qm74	2101	33	the	the	DT
cord-015021-pol2qm74	2101	34	IL-6	IL-6	NNP
cord-015021-pol2qm74	2101	35	gpl30	gpl30	NNP
cord-015021-pol2qm74	2101	36	receptor	receptor	NN
cord-015021-pol2qm74	2101	37	.	.	.
cord-015021-pol2qm74	2102	1	The	the	DT
cord-015021-pol2qm74	2102	2	antisense	antisense	NN
cord-015021-pol2qm74	2102	3	were	be	VBD
cord-015021-pol2qm74	2102	4	5'-AGTTTAGGGATGAGG-3	5'-agtttagggatgagg-3	CD
cord-015021-pol2qm74	2102	5	'	'	''
cord-015021-pol2qm74	2102	6	(	(	-LRB-
cord-015021-pol2qm74	2102	7	ASl	ASl	NNS
cord-015021-pol2qm74	2102	8	)	)	-RRB-
cord-015021-pol2qm74	2102	9	,	,	,
cord-015021-pol2qm74	2102	10	5'-ATCTTCATCTTCTGAAT-3	5'-atcttcatcttctgaat-3	CD
cord-015021-pol2qm74	2102	11	'	'	''
cord-015021-pol2qm74	2102	12	(	(	-LRB-
cord-015021-pol2qm74	2102	13	AS2	AS2	NNP
cord-015021-pol2qm74	2102	14	)	)	-RRB-
cord-015021-pol2qm74	2102	15	,	,	,
cord-015021-pol2qm74	2102	16	5'-AAGTGAATGATTAAAACACT-3	5'-aagtgaatgattaaaacact-3	CD
cord-015021-pol2qm74	2102	17	'	'	''
cord-015021-pol2qm74	2102	18	(	(	-LRB-
cord-015021-pol2qm74	2102	19	AS3	AS3	NNP
cord-015021-pol2qm74	2102	20	)	)	-RRB-
cord-015021-pol2qm74	2102	21	,	,	,
cord-015021-pol2qm74	2102	22	5'-AAACCTTTATAGGCG-3	5'-AAACCTTTATAGGCG-3	NNP
cord-015021-pol2qm74	2102	23	'	'	''
cord-015021-pol2qm74	2102	24	(	(	-LRB-
cord-015021-pol2qm74	2102	25	AS4	AS4	NNP
cord-015021-pol2qm74	2102	26	)	)	-RRB-
cord-015021-pol2qm74	2102	27	,	,	,
cord-015021-pol2qm74	2102	28	and	and	CC
cord-015021-pol2qm74	2102	29	5'-CGTTCTACAACTGCAACGT-3	5'-cgttctacaactgcaacgt-3	CD
cord-015021-pol2qm74	2102	30	'	'	''
cord-015021-pol2qm74	2102	31	(	(	-LRB-
cord-015021-pol2qm74	2102	32	AS5	AS5	NNP
cord-015021-pol2qm74	2102	33	)	)	-RRB-
cord-015021-pol2qm74	2102	34	.	.	.
cord-015021-pol2qm74	2103	1	Using	use	VBG
cord-015021-pol2qm74	2103	2	HepG2	HepG2	NNP
cord-015021-pol2qm74	2103	3	,	,	,
cord-015021-pol2qm74	2103	4	the	the	DT
cord-015021-pol2qm74	2103	5	biological	biological	JJ
cord-015021-pol2qm74	2103	6	effects	effect	NNS
cord-015021-pol2qm74	2103	7	of	of	IN
cord-015021-pol2qm74	2103	8	these	these	DT
cord-015021-pol2qm74	2103	9	antisense	antisense	NN
cord-015021-pol2qm74	2103	10	complexes	complex	NNS
cord-015021-pol2qm74	2103	11	on	on	IN
cord-015021-pol2qm74	2103	12	the	the	DT
cord-015021-pol2qm74	2103	13	high	high	JJ
cord-015021-pol2qm74	2103	14	affinity	affinity	NN
cord-015021-pol2qm74	2103	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	2103	16	receptor	receptor	NN
cord-015021-pol2qm74	2103	17	were	be	VBD
cord-015021-pol2qm74	2103	18	evaluated	evaluate	VBN
cord-015021-pol2qm74	2103	19	by	by	IN
cord-015021-pol2qm74	2103	20	Scatchard	Scatchard	NNP
cord-015021-pol2qm74	2103	21	analysis	analysis	NN
cord-015021-pol2qm74	2103	22	,	,	,
cord-015021-pol2qm74	2103	23	cellular	cellular	JJ
cord-015021-pol2qm74	2103	24	proliferation	proliferation	NN
cord-015021-pol2qm74	2103	25	,	,	,
cord-015021-pol2qm74	2103	26	and	and	CC
cord-015021-pol2qm74	2103	27	acute	acute	JJ
cord-015021-pol2qm74	2103	28	phase	phase	NN
cord-015021-pol2qm74	2103	29	protein	protein	NN
cord-015021-pol2qm74	2103	30	expression	expression	NN
cord-015021-pol2qm74	2103	31	by	by	IN
cord-015021-pol2qm74	2103	32	radioimmunoprecipitation	radioimmunoprecipitation	NN
cord-015021-pol2qm74	2103	33	and	and	CC
cord-015021-pol2qm74	2103	34	two	two	CD
cord-015021-pol2qm74	2103	35	dimensional	dimensional	JJ
cord-015021-pol2qm74	2103	36	gel	gel	NN
cord-015021-pol2qm74	2103	37	electrophoresis	electrophoresis	NN
cord-015021-pol2qm74	2103	38	.	.	.
cord-015021-pol2qm74	2104	1	Scatchard	Scatchard	NNP
cord-015021-pol2qm74	2104	2	analysis	analysis	NN
cord-015021-pol2qm74	2104	3	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	2104	4	that	that	IN
cord-015021-pol2qm74	2104	5	high	high	JJ
cord-015021-pol2qm74	2104	6	affinity	affinity	NN
cord-015021-pol2qm74	2104	7	receptor	receptor	NN
cord-015021-pol2qm74	2104	8	expression	expression	NN
cord-015021-pol2qm74	2104	9	was	be	VBD
cord-015021-pol2qm74	2104	10	inhibited	inhibit	VBN
cord-015021-pol2qm74	2104	11	by	by	IN
cord-015021-pol2qm74	2104	12	incubation	incubation	NN
cord-015021-pol2qm74	2104	13	of	of	IN
cord-015021-pol2qm74	2104	14	cells	cell	NNS
cord-015021-pol2qm74	2104	15	with	with	IN
cord-015021-pol2qm74	2104	16	ASGP	ASGP	NNP
cord-015021-pol2qm74	2104	17	-	-	HYPH
cord-015021-pol2qm74	2104	18	PLL	PLL	NNP
cord-015021-pol2qm74	2104	19	-	-	HYPH
cord-015021-pol2qm74	2104	20	ASI	ASI	NNP
cord-015021-pol2qm74	2105	1	For	for	IN
cord-015021-pol2qm74	2105	2	24	24	CD
cord-015021-pol2qm74	2105	3	h.	h.	NN
cord-015021-pol2qm74	2105	4	Underivatized	Underivatized	NNP
cord-015021-pol2qm74	2105	5	ASl	ASl	NNS
cord-015021-pol2qm74	2105	6	was	be	VBD
cord-015021-pol2qm74	2105	7	less	less	RBR
cord-015021-pol2qm74	2105	8	effective	effective	JJ
cord-015021-pol2qm74	2105	9	and	and	CC
cord-015021-pol2qm74	2106	1	the	the	DT
cord-015021-pol2qm74	2106	2	complex	complex	NN
cord-015021-pol2qm74	2106	3	,	,	,
cord-015021-pol2qm74	2106	4	ASGP	ASGP	NNP
cord-015021-pol2qm74	2106	5	-	-	HYPH
cord-015021-pol2qm74	2106	6	PLL	PLL	NNP
cord-015021-pol2qm74	2106	7	-	-	HYPH
cord-015021-pol2qm74	2106	8	AS2	AS2	NNP
cord-015021-pol2qm74	2106	9	,	,	,
cord-015021-pol2qm74	2106	10	had	have	VBD
cord-015021-pol2qm74	2106	11	minimal	minimal	JJ
cord-015021-pol2qm74	2106	12	effects	effect	NNS
cord-015021-pol2qm74	2106	13	on	on	IN
cord-015021-pol2qm74	2106	14	high	high	JJ
cord-015021-pol2qm74	2106	15	affinity	affinity	NN
cord-015021-pol2qm74	2106	16	binding	binding	NN
cord-015021-pol2qm74	2106	17	.	.	.
cord-015021-pol2qm74	2107	1	When	when	WRB
cord-015021-pol2qm74	2107	2	the	the	DT
cord-015021-pol2qm74	2107	3	cells	cell	NNS
cord-015021-pol2qm74	2107	4	were	be	VBD
cord-015021-pol2qm74	2107	5	treated	treat	VBN
cord-015021-pol2qm74	2107	6	with	with	IN
cord-015021-pol2qm74	2107	7	the	the	DT
cord-015021-pol2qm74	2107	8	conjugates	conjugate	NNS
cord-015021-pol2qm74	2107	9	and	and	CC
cord-015021-pol2qm74	2107	10	stimulated	stimulate	VBN
cord-015021-pol2qm74	2107	11	with	with	IN
cord-015021-pol2qm74	2107	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	2107	13	(	(	-LRB-
cord-015021-pol2qm74	2107	14	i00	i00	JJ
cord-015021-pol2qm74	2107	15	units	unit	NNS
cord-015021-pol2qm74	2107	16	)	)	-RRB-
cord-015021-pol2qm74	2108	1	ASGP	ASGP	NNP
cord-015021-pol2qm74	2108	2	-	-	HYPH
cord-015021-pol2qm74	2108	3	PLL	PLL	NNP
cord-015021-pol2qm74	2108	4	-	-	HYPH
cord-015021-pol2qm74	2108	5	ASI	ASI	NNP
cord-015021-pol2qm74	2108	6	alone	alone	RB
cord-015021-pol2qm74	2108	7	showed	show	VBD
cord-015021-pol2qm74	2108	8	a	a	DT
cord-015021-pol2qm74	2108	9	dose	dose	NN
cord-015021-pol2qm74	2108	10	dependent	dependent	JJ
cord-015021-pol2qm74	2108	11	(	(	-LRB-
cord-015021-pol2qm74	2108	12	0.i-0.4	0.i-0.4	CD
cord-015021-pol2qm74	2109	1	~M	~M	NFP
cord-015021-pol2qm74	2109	2	)	)	-RRB-
cord-015021-pol2qm74	2109	3	inhibition	inhibition	NN
cord-015021-pol2qm74	2109	4	of	of	IN
cord-015021-pol2qm74	2109	5	3SS	3ss	CD
cord-015021-pol2qm74	2109	6	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	2109	7	synthesis	synthesis	NN
cord-015021-pol2qm74	2109	8	.	.	.
cord-015021-pol2qm74	2110	1	Two	two	CD
cord-015021-pol2qm74	2110	2	dimensional	dimensional	JJ
cord-015021-pol2qm74	2110	3	gel	gel	NN
cord-015021-pol2qm74	2110	4	electrophoresis	electrophoresis	NN
cord-015021-pol2qm74	2110	5	showed	show	VBD
cord-015021-pol2qm74	2110	6	that	that	IN
cord-015021-pol2qm74	2110	7	expression	expression	NN
cord-015021-pol2qm74	2110	8	of	of	IN
cord-015021-pol2qm74	2110	9	other	other	JJ
cord-015021-pol2qm74	2110	10	acute	acute	JJ
cord-015021-pol2qm74	2110	11	phase	phase	NN
cord-015021-pol2qm74	2110	12	proteins	protein	NNS
cord-015021-pol2qm74	2110	13	was	be	VBD
cord-015021-pol2qm74	2110	14	also	also	RB
cord-015021-pol2qm74	2110	15	blocked	block	VBN
cord-015021-pol2qm74	2110	16	.	.	.
cord-015021-pol2qm74	2111	1	These	these	DT
cord-015021-pol2qm74	2111	2	results	result	NNS
cord-015021-pol2qm74	2111	3	indicate	indicate	VBP
cord-015021-pol2qm74	2111	4	that	that	IN
cord-015021-pol2qm74	2111	5	the	the	DT
cord-015021-pol2qm74	2111	6	targeted	target	VBN
cord-015021-pol2qm74	2111	7	delivery	delivery	NN
cord-015021-pol2qm74	2111	8	of	of	IN
cord-015021-pol2qm74	2111	9	antisense	antisense	NN
cord-015021-pol2qm74	2111	10	molecules	molecule	NNS
cord-015021-pol2qm74	2111	11	via	via	IN
cord-015021-pol2qm74	2111	12	conjugates	conjugate	NNS
cord-015021-pol2qm74	2111	13	recognized	recognize	VBN
cord-015021-pol2qm74	2111	14	by	by	IN
cord-015021-pol2qm74	2111	15	the	the	DT
cord-015021-pol2qm74	2111	16	asialoglycoprotein	asialoglycoprotein	NNP
cord-015021-pol2qm74	2111	17	receptor	receptor	NN
cord-015021-pol2qm74	2111	18	can	can	MD
cord-015021-pol2qm74	2111	19	block	block	VB
cord-015021-pol2qm74	2111	20	the	the	DT
cord-015021-pol2qm74	2111	21	cytokine	cytokine	NN
cord-015021-pol2qm74	2111	22	stimulated	stimulate	VBD
cord-015021-pol2qm74	2111	23	acute	acute	JJ
cord-015021-pol2qm74	2111	24	phase	phase	NN
cord-015021-pol2qm74	2111	25	protein	protein	NN
cord-015021-pol2qm74	2111	26	response	response	NN
cord-015021-pol2qm74	2111	27	in	in	IN
cord-015021-pol2qm74	2111	28	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	2111	29	,	,	,
cord-015021-pol2qm74	2111	30	This	this	DT
cord-015021-pol2qm74	2111	31	approach	approach	NN
cord-015021-pol2qm74	2111	32	may	may	MD
cord-015021-pol2qm74	2111	33	be	be	VB
cord-015021-pol2qm74	2111	34	relevant	relevant	JJ
cord-015021-pol2qm74	2111	35	to	to	IN
cord-015021-pol2qm74	2111	36	the	the	DT
cord-015021-pol2qm74	2111	37	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	2111	38	management	management	NN
cord-015021-pol2qm74	2111	39	of	of	IN
cord-015021-pol2qm74	2111	40	patients	patient	NNS
cord-015021-pol2qm74	2111	41	with	with	IN
cord-015021-pol2qm74	2111	42	severe	severe	JJ
cord-015021-pol2qm74	2111	43	injury	injury	NN
cord-015021-pol2qm74	2111	44	and	and	CC
cord-015021-pol2qm74	2111	45	sepsis	sepsis	NN
cord-015021-pol2qm74	2111	46	.	.	.
cord-015021-pol2qm74	2112	1	It	-PRON-	PRP
cord-015021-pol2qm74	2112	2	has	have	VBZ
cord-015021-pol2qm74	2112	3	been	be	VBN
cord-015021-pol2qm74	2112	4	established	establish	VBN
cord-015021-pol2qm74	2112	5	that	that	IN
cord-015021-pol2qm74	2112	6	immune	immune	JJ
cord-015021-pol2qm74	2112	7	cells	cell	NNS
cord-015021-pol2qm74	2112	8	are	be	VBP
cord-015021-pol2qm74	2112	9	able	able	JJ
cord-015021-pol2qm74	2112	10	to	to	TO
cord-015021-pol2qm74	2112	11	express	express	VB
cord-015021-pol2qm74	2112	12	neuropeptide	neuropeptide	NN
cord-015021-pol2qm74	2112	13	genes	gene	NNS
cord-015021-pol2qm74	2112	14	and	and	CC
cord-015021-pol2qm74	2112	15	to	to	TO
cord-015021-pol2qm74	2112	16	release	release	VB
cord-015021-pol2qm74	2112	17	products	product	NNS
cord-015021-pol2qm74	2112	18	that	that	WDT
cord-015021-pol2qm74	2112	19	were	be	VBD
cord-015021-pol2qm74	2112	20	considered	consider	VBN
cord-015021-pol2qm74	2112	21	to	to	TO
cord-015021-pol2qm74	2112	22	be	be	VB
cord-015021-pol2qm74	2112	23	of	of	IN
cord-015021-pol2qm74	2112	24	neuroendocrine	neuroendocrine	JJ
cord-015021-pol2qm74	2112	25	origin	origin	NN
cord-015021-pol2qm74	2112	26	.	.	.
cord-015021-pol2qm74	2113	1	We	-PRON-	PRP
cord-015021-pol2qm74	2113	2	have	have	VBP
cord-015021-pol2qm74	2113	3	shown	show	VBN
cord-015021-pol2qm74	2113	4	that	that	IN
cord-015021-pol2qm74	2113	5	Proenkephalin	Proenkephalin	NNP
cord-015021-pol2qm74	2113	6	(	(	-LRB-
cord-015021-pol2qm74	2113	7	PENK	PENK	NNP
cord-015021-pol2qm74	2113	8	)	)	-RRB-
cord-015021-pol2qm74	2113	9	,	,	,
cord-015021-pol2qm74	2113	10	a	a	DT
cord-015021-pol2qm74	2113	11	neuropeptide	neuropeptide	NN
cord-015021-pol2qm74	2113	12	encoding	encoding	NN
cord-015021-pol2qm74	2113	13	gene	gene	NN
cord-015021-pol2qm74	2113	14	,	,	,
cord-015021-pol2qm74	2113	15	is	be	VBZ
cord-015021-pol2qm74	2113	16	expressed	express	VBN
cord-015021-pol2qm74	2113	17	in	in	IN
cord-015021-pol2qm74	2113	18	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	2113	19	cells	cell	NNS
cord-015021-pol2qm74	2113	20	in	in	IN
cord-015021-pol2qm74	2113	21	culture	culture	NN
cord-015021-pol2qm74	2113	22	.	.	.
cord-015021-pol2qm74	2114	1	To	to	TO
cord-015021-pol2qm74	2114	2	study	study	VB
cord-015021-pol2qm74	2114	3	the	the	DT
cord-015021-pol2qm74	2114	4	physiological	physiological	JJ
cord-015021-pol2qm74	2114	5	significance	significance	NN
cord-015021-pol2qm74	2114	6	of	of	IN
cord-015021-pol2qm74	2114	7	these	these	DT
cord-015021-pol2qm74	2114	8	observations	observation	NNS
cord-015021-pol2qm74	2114	9	we	-PRON-	PRP
cord-015021-pol2qm74	2114	10	have	have	VBP
cord-015021-pol2qm74	2114	11	used	use	VBN
cord-015021-pol2qm74	2114	12	the	the	DT
cord-015021-pol2qm74	2114	13	model	model	NN
cord-015021-pol2qm74	2114	14	of	of	IN
cord-015021-pol2qm74	2114	15	experimental	experimental	JJ
cord-015021-pol2qm74	2114	16	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2114	17	.	.	.
cord-015021-pol2qm74	2115	1	In	in	IN
cord-015021-pol2qm74	2115	2	this	this	DT
cord-015021-pol2qm74	2115	3	model	model	NN
cord-015021-pol2qm74	2115	4	,	,	,
cord-015021-pol2qm74	2115	5	a	a	DT
cord-015021-pol2qm74	2115	6	disease	disease	NN
cord-015021-pol2qm74	2115	7	state	state	NN
cord-015021-pol2qm74	2115	8	is	be	VBZ
cord-015021-pol2qm74	2115	9	induced	induce	VBN
cord-015021-pol2qm74	2115	10	by	by	IN
cord-015021-pol2qm74	2115	11	bacterial	bacterial	JJ
cord-015021-pol2qm74	2115	12	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	2115	13	(	(	-LRB-
cord-015021-pol2qm74	2115	14	LPS	LPS	NNP
cord-015021-pol2qm74	2115	15	)	)	-RRB-
cord-015021-pol2qm74	2115	16	,	,	,
cord-015021-pol2qm74	2115	17	that	that	WDT
cord-015021-pol2qm74	2115	18	activates	activate	VBZ
cord-015021-pol2qm74	2115	19	the	the	DT
cord-015021-pol2qm74	2115	20	immune	immune	JJ
cord-015021-pol2qm74	2115	21	system	system	NN
cord-015021-pol2qm74	2115	22	,	,	,
cord-015021-pol2qm74	2115	23	the	the	DT
cord-015021-pol2qm74	2115	24	adrenocortical	adrenocortical	JJ
cord-015021-pol2qm74	2115	25	axis	axis	NN
cord-015021-pol2qm74	2115	26	and	and	CC
cord-015021-pol2qm74	2115	27	the	the	DT
cord-015021-pol2qm74	2115	28	nervous	nervous	JJ
cord-015021-pol2qm74	2115	29	system	system	NN
cord-015021-pol2qm74	2115	30	.	.	.
cord-015021-pol2qm74	2116	1	We	-PRON-	PRP
cord-015021-pol2qm74	2116	2	found	find	VBD
cord-015021-pol2qm74	2116	3	that	that	IN
cord-015021-pol2qm74	2116	4	the	the	DT
cord-015021-pol2qm74	2116	5	expression	expression	NN
cord-015021-pol2qm74	2116	6	of	of	IN
cord-015021-pol2qm74	2116	7	PENKmRNA	penkmrna	NN
cord-015021-pol2qm74	2116	8	is	be	VBZ
cord-015021-pol2qm74	2116	9	markedly	markedly	RB
cord-015021-pol2qm74	2116	10	enhanced	enhance	VBN
cord-015021-pol2qm74	2116	11	in	in	IN
cord-015021-pol2qm74	2116	12	vivo	vivo	NN
cord-015021-pol2qm74	2116	13	immediately	immediately	RB
cord-015021-pol2qm74	2116	14	after	after	IN
cord-015021-pol2qm74	2116	15	LPS	lp	NNS
cord-015021-pol2qm74	2116	16	injection	injection	NN
cord-015021-pol2qm74	2116	17	both	both	CC
cord-015021-pol2qm74	2116	18	in	in	IN
cord-015021-pol2qm74	2116	19	the	the	DT
cord-015021-pol2qm74	2116	20	adrenal	adrenal	JJ
cord-015021-pol2qm74	2116	21	glands	gland	NNS
cord-015021-pol2qm74	2116	22	and	and	CC
cord-015021-pol2qm74	2116	23	in	in	IN
cord-015021-pol2qm74	2116	24	the	the	DT
cord-015021-pol2qm74	2116	25	lymph	lymph	NN
cord-015021-pol2qm74	2116	26	nodes	node	NNS
cord-015021-pol2qm74	2116	27	.	.	.
cord-015021-pol2qm74	2117	1	In	in	IN
cord-015021-pol2qm74	2117	2	situ	situ	JJ
cord-015021-pol2qm74	2117	3	hybridization	hybridization	NN
cord-015021-pol2qm74	2117	4	analysis	analysis	NN
cord-015021-pol2qm74	2117	5	combined	combine	VBN
cord-015021-pol2qm74	2117	6	with	with	IN
cord-015021-pol2qm74	2117	7	immunohisto	immunohisto	NN
cord-015021-pol2qm74	2117	8	-	-	HYPH
cord-015021-pol2qm74	2117	9	chemistry	chemistry	NNP
cord-015021-pol2qm74	2117	10	indicated	indicate	VBD
cord-015021-pol2qm74	2117	11	that	that	IN
cord-015021-pol2qm74	2117	12	the	the	DT
cord-015021-pol2qm74	2117	13	induced	induce	VBN
cord-015021-pol2qm74	2117	14	PENK	PENK	NNP
cord-015021-pol2qm74	2117	15	expression	expression	NN
cord-015021-pol2qm74	2117	16	is	be	VBZ
cord-015021-pol2qm74	2117	17	confined	confine	VBN
cord-015021-pol2qm74	2117	18	to	to	IN
cord-015021-pol2qm74	2117	19	macrephages	macrephage	NNS
cord-015021-pol2qm74	2117	20	within	within	IN
cord-015021-pol2qm74	2117	21	the	the	DT
cord-015021-pol2qm74	2117	22	lymph	lymph	NN
cord-015021-pol2qm74	2117	23	nodes	node	NNS
cord-015021-pol2qm74	2117	24	and	and	CC
cord-015021-pol2qm74	2117	25	chromaffin	chromaffin	NN
cord-015021-pol2qm74	2117	26	cells	cell	NNS
cord-015021-pol2qm74	2117	27	in	in	IN
cord-015021-pol2qm74	2117	28	the	the	DT
cord-015021-pol2qm74	2117	29	adrenal	adrenal	JJ
cord-015021-pol2qm74	2117	30	medulla	medulla	NN
cord-015021-pol2qm74	2117	31	.	.	.
cord-015021-pol2qm74	2118	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2118	2	,	,	,
cord-015021-pol2qm74	2118	3	this	this	DT
cord-015021-pol2qm74	2118	4	expression	expression	NN
cord-015021-pol2qm74	2118	5	in	in	IN
cord-015021-pol2qm74	2118	6	lymph	lymph	NN
cord-015021-pol2qm74	2118	7	nodes	node	NNS
cord-015021-pol2qm74	2118	8	is	be	VBZ
cord-015021-pol2qm74	2118	9	modulated	modulate	VBN
cord-015021-pol2qm74	2118	10	by	by	IN
cord-015021-pol2qm74	2118	11	ligands	ligand	NNS
cord-015021-pol2qm74	2118	12	of	of	IN
cord-015021-pol2qm74	2118	13	the	the	DT
cord-015021-pol2qm74	2118	14	adrenergic	adrenergic	JJ
cord-015021-pol2qm74	2118	15	system	system	NN
cord-015021-pol2qm74	2118	16	.	.	.
cord-015021-pol2qm74	2119	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2119	2	results	result	NNS
cord-015021-pol2qm74	2119	3	strongly	strongly	RB
cord-015021-pol2qm74	2119	4	support	support	VBP
cord-015021-pol2qm74	2119	5	the	the	DT
cord-015021-pol2qm74	2119	6	notion	notion	NN
cord-015021-pol2qm74	2119	7	that	that	IN
cord-015021-pol2qm74	2119	8	immune	immune	JJ
cord-015021-pol2qm74	2119	9	derived	derive	VBN
cord-015021-pol2qm74	2119	10	opioids	opioid	NNS
cord-015021-pol2qm74	2119	11	participate	participate	VBP
cord-015021-pol2qm74	2119	12	in	in	IN
cord-015021-pol2qm74	2119	13	the	the	DT
cord-015021-pol2qm74	2119	14	bidirectional	bidirectional	JJ
cord-015021-pol2qm74	2119	15	communication	communication	NN
cord-015021-pol2qm74	2119	16	between	between	IN
cord-015021-pol2qm74	2119	17	the	the	DT
cord-015021-pol2qm74	2119	18	nervous	nervous	JJ
cord-015021-pol2qm74	2119	19	and	and	CC
cord-015021-pol2qm74	2119	20	immune	immune	JJ
cord-015021-pol2qm74	2119	21	systems	system	NNS
cord-015021-pol2qm74	2119	22	.	.	.
cord-015021-pol2qm74	2120	1	of	of	IN
cord-015021-pol2qm74	2120	2	Neurology	Neurology	NNP
cord-015021-pol2qm74	2120	3	Hadassah	Hadassah	NNP
cord-015021-pol2qm74	2120	4	University	University	NNP
cord-015021-pol2qm74	2120	5	Hospital	Hospital	NNP
cord-015021-pol2qm74	2120	6	,	,	,
cord-015021-pol2qm74	2120	7	Jerusalem	Jerusalem	NNP
cord-015021-pol2qm74	2120	8	91120	91120	CD
cord-015021-pol2qm74	2120	9	,	,	,
cord-015021-pol2qm74	2120	10	Israel	Israel	NNP
cord-015021-pol2qm74	2120	11	.	.	.
cord-015021-pol2qm74	2121	1	Objectives	objective	NNS
cord-015021-pol2qm74	2121	2	of	of	IN
cord-015021-pol2qm74	2121	3	the	the	DT
cord-015021-pol2qm74	2121	4	study	study	NN
cord-015021-pol2qm74	2121	5	:	:	:
cord-015021-pol2qm74	2121	6	Multiple	multiple	JJ
cord-015021-pol2qm74	2121	7	-	-	HYPH
cord-015021-pol2qm74	2121	8	organ	organ	NN
cord-015021-pol2qm74	2121	9	-	-	HYPH
cord-015021-pol2qm74	2121	10	failure	failure	NN
cord-015021-pol2qm74	2121	11	is	be	VBZ
cord-015021-pol2qm74	2121	12	recognized	recognize	VBN
cord-015021-pol2qm74	2121	13	as	as	IN
cord-015021-pol2qm74	2121	14	the	the	DT
cord-015021-pol2qm74	2121	15	most	most	RBS
cord-015021-pol2qm74	2121	16	severe	severe	JJ
cord-015021-pol2qm74	2121	17	,	,	,
cord-015021-pol2qm74	2121	18	and	and	CC
cord-015021-pol2qm74	2121	19	often	often	RB
cord-015021-pol2qm74	2121	20	lethal	lethal	JJ
cord-015021-pol2qm74	2121	21	,	,	,
cord-015021-pol2qm74	2121	22	complication	complication	NN
cord-015021-pol2qm74	2121	23	after	after	IN
cord-015021-pol2qm74	2121	24	multiple	multiple	JJ
cord-015021-pol2qm74	2121	25	trauma	trauma	NN
cord-015021-pol2qm74	2121	26	.	.	.
cord-015021-pol2qm74	2122	1	However	however	RB
cord-015021-pol2qm74	2122	2	there	there	EX
cord-015021-pol2qm74	2122	3	is	be	VBZ
cord-015021-pol2qm74	2122	4	no	no	DT
cord-015021-pol2qm74	2122	5	adeqate	adeqate	NNP
cord-015021-pol2qm74	2122	6	animal	animal	NN
cord-015021-pol2qm74	2122	7	model	model	NN
cord-015021-pol2qm74	2122	8	available	available	JJ
cord-015021-pol2qm74	2122	9	.	.	.
cord-015021-pol2qm74	2123	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2123	2	goal	goal	NN
cord-015021-pol2qm74	2123	3	was	be	VBD
cord-015021-pol2qm74	2123	4	to	to	TO
cord-015021-pol2qm74	2123	5	develop	develop	VB
cord-015021-pol2qm74	2123	6	an	an	DT
cord-015021-pol2qm74	2123	7	animal	animal	NN
cord-015021-pol2qm74	2123	8	model	model	NN
cord-015021-pol2qm74	2123	9	,	,	,
cord-015021-pol2qm74	2123	10	in	in	IN
cord-015021-pol2qm74	2123	11	which	which	WDT
cord-015021-pol2qm74	2123	12	reproducable	reproducable	JJ
cord-015021-pol2qm74	2123	13	irreversible	irreversible	JJ
cord-015021-pol2qm74	2123	14	failure	failure	NN
cord-015021-pol2qm74	2123	15	of	of	IN
cord-015021-pol2qm74	2123	16	parenchymal	parenchymal	JJ
cord-015021-pol2qm74	2123	17	organs	organ	NNS
cord-015021-pol2qm74	2123	18	is	be	VBZ
cord-015021-pol2qm74	2123	19	achieved	achieve	VBN
cord-015021-pol2qm74	2123	20	in	in	IN
cord-015021-pol2qm74	2123	21	the	the	DT
cord-015021-pol2qm74	2123	22	late	late	JJ
cord-015021-pol2qm74	2123	23	phase	phase	NN
cord-015021-pol2qm74	2123	24	after	after	IN
cord-015021-pol2qm74	2123	25	insults	insult	NNS
cord-015021-pol2qm74	2123	26	in	in	IN
cord-015021-pol2qm74	2123	27	the	the	DT
cord-015021-pol2qm74	2123	28	early	early	JJ
cord-015021-pol2qm74	2123	29	phase	phase	NN
cord-015021-pol2qm74	2123	30	(	(	-LRB-
cord-015021-pol2qm74	2123	31	trauma	trauma	NN
cord-015021-pol2qm74	2123	32	)	)	-RRB-
cord-015021-pol2qm74	2123	33	.	.	.
cord-015021-pol2qm74	2124	1	Materials	material	NNS
cord-015021-pol2qm74	2124	2	and	and	CC
cord-015021-pol2qm74	2124	3	methods	method	NNS
cord-015021-pol2qm74	2124	4	:	:	:
cord-015021-pol2qm74	2124	5	l0	l0	NNP
cord-015021-pol2qm74	2124	6	female	female	NNP
cord-015021-pol2qm74	2124	7	Merino	Merino	NNP
cord-015021-pol2qm74	2124	8	-	-	HYPH
cord-015021-pol2qm74	2124	9	sheep	sheep	NN
cord-015021-pol2qm74	2124	10	were	be	VBD
cord-015021-pol2qm74	2124	11	included	include	VBN
cord-015021-pol2qm74	2124	12	(	(	-LRB-
cord-015021-pol2qm74	2124	13	mean	mean	VB
cord-015021-pol2qm74	2124	14	weight	weight	NN
cord-015021-pol2qm74	2124	15	:	:	:
cord-015021-pol2qm74	2124	16	30	30	CD
cord-015021-pol2qm74	2124	17	kg	kg	NN
cord-015021-pol2qm74	2124	18	)	)	-RRB-
cord-015021-pol2qm74	2124	19	.	.	.
cord-015021-pol2qm74	2125	1	day	day	NN
cord-015021-pol2qm74	2125	2	0	0	CD
cord-015021-pol2qm74	2125	3	:	:	:
cord-015021-pol2qm74	2125	4	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	2125	5	shock	shock	NN
cord-015021-pol2qm74	2125	6	(	(	-LRB-
cord-015021-pol2qm74	2125	7	mean	mean	VB
cord-015021-pol2qm74	2125	8	arterial	arterial	JJ
cord-015021-pol2qm74	2125	9	pressure	pressure	NN
cord-015021-pol2qm74	2125	10	(	(	-LRB-
cord-015021-pol2qm74	2125	11	MAP	MAP	NNP
cord-015021-pol2qm74	2125	12	)	)	-RRB-
cord-015021-pol2qm74	2125	13	50mmHg	50mmhg	CD
cord-015021-pol2qm74	2125	14	for	for	IN
cord-015021-pol2qm74	2125	15	2	2	CD
cord-015021-pol2qm74	2125	16	hrs	hrs	NN
cord-015021-pol2qm74	2125	17	.	.	.
cord-015021-pol2qm74	2125	18	)	)	-RRB-
cord-015021-pol2qm74	2125	19	,	,	,
cord-015021-pol2qm74	2125	20	closed	closed	JJ
cord-015021-pol2qm74	2125	21	femoral	femoral	JJ
cord-015021-pol2qm74	2125	22	nailing	nailing	NN
cord-015021-pol2qm74	2125	23	(	(	-LRB-
cord-015021-pol2qm74	2125	24	AO	ao	NN
cord-015021-pol2qm74	2125	25	-	-	HYPH
cord-015021-pol2qm74	2125	26	technique	technique	NN
cord-015021-pol2qm74	2125	27	)	)	-RRB-
cord-015021-pol2qm74	2125	28	,	,	,
cord-015021-pol2qm74	2125	29	day	day	NN
cord-015021-pol2qm74	2125	30	1	1	CD
cord-015021-pol2qm74	2125	31	-	-	SYM
cord-015021-pol2qm74	2125	32	5	5	CD
cord-015021-pol2qm74	2125	33	:	:	:
cord-015021-pol2qm74	2126	1	bolusinjection	bolusinjection	NN
cord-015021-pol2qm74	2126	2	of	of	IN
cord-015021-pol2qm74	2126	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2126	4	(	(	-LRB-
cord-015021-pol2qm74	2126	5	ET	et	NN
cord-015021-pol2qm74	2126	6	)	)	-RRB-
cord-015021-pol2qm74	2127	1	(	(	-LRB-
cord-015021-pol2qm74	2127	2	0,75~tg	0,75~tg	CD
cord-015021-pol2qm74	2127	3	/	/	SYM
cord-015021-pol2qm74	2127	4	kgBW	kgBW	NNP
cord-015021-pol2qm74	2127	5	)	)	-RRB-
cord-015021-pol2qm74	2128	1	und	und	NNP
cord-015021-pol2qm74	2128	2	zymosan	zymosan	NNP
cord-015021-pol2qm74	2128	3	-	-	HYPH
cord-015021-pol2qm74	2128	4	activated	activate	VBN
cord-015021-pol2qm74	2128	5	plasma	plasma	NN
cord-015021-pol2qm74	2128	6	(	(	-LRB-
cord-015021-pol2qm74	2128	7	ZAP	ZAP	NNP
cord-015021-pol2qm74	2128	8	)	)	-RRB-
cord-015021-pol2qm74	2128	9	(	(	-LRB-
cord-015021-pol2qm74	2128	10	20ml	20ml	LS
cord-015021-pol2qm74	2128	11	)	)	-RRB-
cord-015021-pol2qm74	2129	1	every	every	DT
cord-015021-pol2qm74	2129	2	12hrs	12hrs	NN
cord-015021-pol2qm74	2129	3	.	.	.
cord-015021-pol2qm74	2130	1	,	,	,
cord-015021-pol2qm74	2130	2	day	day	NN
cord-015021-pol2qm74	2130	3	6	6	CD
cord-015021-pol2qm74	2130	4	-	-	SYM
cord-015021-pol2qm74	2130	5	10	10	CD
cord-015021-pol2qm74	2130	6	:	:	:
cord-015021-pol2qm74	2130	7	observation	observation	NN
cord-015021-pol2qm74	2130	8	.	.	.
cord-015021-pol2qm74	2131	1	Bronchoalveolar	Bronchoalveolar	NNP
cord-015021-pol2qm74	2131	2	lavage	lavage	NN
cord-015021-pol2qm74	2131	3	(	(	-LRB-
cord-015021-pol2qm74	2131	4	BAL	bal	NN
cord-015021-pol2qm74	2131	5	)	)	-RRB-
cord-015021-pol2qm74	2131	6	:	:	:
cord-015021-pol2qm74	2131	7	day	day	NN
cord-015021-pol2qm74	2131	8	1	1	CD
cord-015021-pol2qm74	2131	9	,	,	,
cord-015021-pol2qm74	2131	10	6	6	CD
cord-015021-pol2qm74	2131	11	,	,	,
cord-015021-pol2qm74	2131	12	10	10	CD
cord-015021-pol2qm74	2131	13	.	.	.
cord-015021-pol2qm74	2132	1	The	the	DT
cord-015021-pol2qm74	2132	2	course	course	NN
cord-015021-pol2qm74	2132	3	of	of	IN
cord-015021-pol2qm74	2132	4	representative	representative	JJ
cord-015021-pol2qm74	2132	5	parameters	parameter	NNS
cord-015021-pol2qm74	2132	6	of	of	IN
cord-015021-pol2qm74	2132	7	organ	organ	NN
cord-015021-pol2qm74	2132	8	function	function	NN
cord-015021-pol2qm74	2132	9	was	be	VBD
cord-015021-pol2qm74	2132	10	documented	document	VBN
cord-015021-pol2qm74	2132	11	:	:	:
cord-015021-pol2qm74	2132	12	COcardiac	COcardiac	NNP
cord-015021-pol2qm74	2132	13	output	output	NN
cord-015021-pol2qm74	2132	14	(	(	-LRB-
cord-015021-pol2qm74	2132	15	I	i	NN
cord-015021-pol2qm74	2132	16	/	/	SYM
cord-015021-pol2qm74	2132	17	min	min	NNP
cord-015021-pol2qm74	2132	18	)	)	-RRB-
cord-015021-pol2qm74	2132	19	,	,	,
cord-015021-pol2qm74	2132	20	SVR	SVR	NNP
cord-015021-pol2qm74	2132	21	-systemic	-systemic	JJ
cord-015021-pol2qm74	2132	22	vascular	vascular	JJ
cord-015021-pol2qm74	2132	23	resistence	resistence	NN
cord-015021-pol2qm74	2132	24	(	(	-LRB-
cord-015021-pol2qm74	2132	25	dyn	dyn	NNP
cord-015021-pol2qm74	2132	26	~	~	NNP
cord-015021-pol2qm74	2132	27	s	s	NNP
cord-015021-pol2qm74	2132	28	cm-5	cm-5	NN
cord-015021-pol2qm74	2132	29	)	)	-RRB-
cord-015021-pol2qm74	2133	1	,	,	,
cord-015021-pol2qm74	2133	2	PAP	pap	NN
cord-015021-pol2qm74	2133	3	-putm.art.pressure	-putm.art.pressure	NN
cord-015021-pol2qm74	2133	4	(	(	-LRB-
cord-015021-pol2qm74	2133	5	mmHg	mmHg	NNP
cord-015021-pol2qm74	2133	6	)	)	-RRB-
cord-015021-pol2qm74	2133	7	,	,	,
cord-015021-pol2qm74	2133	8	PaP2	pap2	JJ
cord-015021-pol2qm74	2133	9	-arterial	-arterial	JJ
cord-015021-pol2qm74	2133	10	oxygen	oxygen	NN
cord-015021-pol2qm74	2133	11	pressure	pressure	NN
cord-015021-pol2qm74	2133	12	(	(	-LRB-
cord-015021-pol2qm74	2133	13	mmHg	mmHg	NNP
cord-015021-pol2qm74	2133	14	)	)	-RRB-
cord-015021-pol2qm74	2133	15	,	,	.
cord-015021-pol2qm74	2134	1	Bill	Bill	NNP
cord-015021-pol2qm74	2134	2	-Bilirubin	-Bilirubin	.
cord-015021-pol2qm74	2135	1	(	(	-LRB-
cord-015021-pol2qm74	2135	2	;	;	:
cord-015021-pol2qm74	2135	3	xmoV1	xmov1	ADD
cord-015021-pol2qm74	2135	4	)	)	-RRB-
cord-015021-pol2qm74	2135	5	,	,	,
cord-015021-pol2qm74	2135	6	CrCI	CrCI	NNP
cord-015021-pol2qm74	2135	7	-Creatinin	-Creatinin	VBZ
cord-015021-pol2qm74	2135	8	Clearence	Clearence	NNP
cord-015021-pol2qm74	2135	9	(	(	-LRB-
cord-015021-pol2qm74	2135	10	ml	ml	NN
cord-015021-pol2qm74	2135	11	/	/	SYM
cord-015021-pol2qm74	2135	12	min	min	NN
cord-015021-pol2qm74	2135	13	)	)	-RRB-
cord-015021-pol2qm74	2136	1	Statistics	statistic	NNS
cord-015021-pol2qm74	2136	2	:	:	:
cord-015021-pol2qm74	2136	3	Data	datum	NNS
cord-015021-pol2qm74	2136	4	as	as	IN
cord-015021-pol2qm74	2136	5	means+SEM	means+SEM	NNP
cord-015021-pol2qm74	2136	6	,	,	,
cord-015021-pol2qm74	2136	7	*	*	NFP
cord-015021-pol2qm74	2136	8	significant	significant	JJ
cord-015021-pol2qm74	2136	9	from	from	IN
cord-015021-pol2qm74	2136	10	baseline	baseline	JJ
cord-015021-pol2qm74	2136	11	(	(	-LRB-
cord-015021-pol2qm74	2136	12	Wileoxon	Wileoxon	NNP
cord-015021-pol2qm74	2136	13	Test	test	NN
cord-015021-pol2qm74	2136	14	;	;	.
cord-015021-pol2qm74	2137	1	p<0005	p<0005	NNP
cord-015021-pol2qm74	2137	2	)	)	-RRB-
cord-015021-pol2qm74	2137	3	Results	result	VBZ
cord-015021-pol2qm74	2137	4	:	:	:
cord-015021-pol2qm74	2137	5	baseline	baseline	JJ
cord-015021-pol2qm74	2137	6	day	day	NN
cord-015021-pol2qm74	2137	7	4	4	CD
cord-015021-pol2qm74	2137	8	day	day	NN
cord-015021-pol2qm74	2137	9	6	6	CD
cord-015021-pol2qm74	2137	10	day	day	NN
cord-015021-pol2qm74	2137	11	8	8	CD
cord-015021-pol2qm74	2137	12	day	day	NN
cord-015021-pol2qm74	2137	13	10	10	CD
cord-015021-pol2qm74	2137	14	heart	heart	NN
cord-015021-pol2qm74	2137	15	:	:	:
cord-015021-pol2qm74	2137	16	CO	CO	NNP
cord-015021-pol2qm74	2137	17	4,96_+0,32	4,96_+0,32	CD
cord-015021-pol2qm74	2138	1	5,33_+0,36	5,33_+0,36	CD
cord-015021-pol2qm74	2139	1	5,4_+0,2	5,4_+0,2	CD
cord-015021-pol2qm74	2139	2	7,30_+0,77	7,30_+0,77	CD
cord-015021-pol2qm74	2140	1	*	*	NFP
cord-015021-pol2qm74	2141	1	7,98_+0,66	7,98_+0,66	LS
cord-015021-pol2qm74	2142	1	*	*	NFP
cord-015021-pol2qm74	2142	2	SVR1520_+134	SVR1520_+134	NNP
cord-015021-pol2qm74	2142	3	1395	1395	CD
cord-015021-pol2qm74	2142	4	+	+	SYM
cord-015021-pol2qm74	2142	5	141	141	CD
cord-015021-pol2qm74	2142	6	1403_+89	1403_+89	CD
cord-015021-pol2qm74	2142	7	1119+_122	1119+_122	CD
cord-015021-pol2qm74	2142	8	"	"	''
cord-015021-pol2qm74	2143	1	1089	1089	CD
cord-015021-pol2qm74	2143	2	+	+	SYM
cord-015021-pol2qm74	2143	3	-91	-91	NN
cord-015021-pol2qm74	2143	4	"	"	``
cord-015021-pol2qm74	2143	5	lung	lung	NN
cord-015021-pol2qm74	2143	6	:	:	:
cord-015021-pol2qm74	2143	7	PAP	PAP	NNP
cord-015021-pol2qm74	2143	8	17,0_-20,7	17,0_-20,7	CD
cord-015021-pol2qm74	2143	9	19,6_+1,6	19,6_+1,6	CD
cord-015021-pol2qm74	2143	10	"	"	''
cord-015021-pol2qm74	2143	11	22,0	22,0	CD
cord-015021-pol2qm74	2144	1	+	+	CC
cord-015021-pol2qm74	2145	1	-1,2"25,8	-1,2"25,8	XX
cord-015021-pol2qm74	2146	1	+2,0	+2,0	DT
cord-015021-pol2qm74	2147	1	"	"	``
cord-015021-pol2qm74	2147	2	28,8	28,8	CD
cord-015021-pol2qm74	2147	3	+	+	CC
cord-015021-pol2qm74	2148	1	-1,7	-1,7	:
cord-015021-pol2qm74	2148	2	'	'	''
cord-015021-pol2qm74	2149	1	PaP2	PaP2	NNP
cord-015021-pol2qm74	2150	1	103,1	103,1	CD
cord-015021-pol2qm74	2150	2	+	+	CC
cord-015021-pol2qm74	2150	3	1,5101,5	1,5101,5	CD
cord-015021-pol2qm74	2151	1	+	+	CC
cord-015021-pol2qm74	2151	2	-5,7	-5,7	.
cord-015021-pol2qm74	2152	1	97,3_+4,7	97,3_+4,7	CD
cord-015021-pol2qm74	2153	1	91,9	91,9	LS
cord-015021-pol2qm74	2153	2	+	+	CC
cord-015021-pol2qm74	2154	1	-5,6	-5,6	NNP
cord-015021-pol2qm74	2155	1	89,8+_3,9	89,8+_3,9	LS
cord-015021-pol2qm74	2155	2	*	*	NFP
cord-015021-pol2qm74	2155	3	liver	liver	NN
cord-015021-pol2qm74	2155	4	:	:	:
cord-015021-pol2qm74	2155	5	Bill	Bill	NNP
cord-015021-pol2qm74	2155	6	2	2	CD
cord-015021-pol2qm74	2155	7	,	,	,
cord-015021-pol2qm74	2155	8	94_+0	94_+0	CD
cord-015021-pol2qm74	2155	9	,	,	,
cord-015021-pol2qm74	2155	10	344	344	CD
cord-015021-pol2qm74	2155	11	,	,	,
cord-015021-pol2qm74	2155	12	82_+1	82_+1	CD
cord-015021-pol2qm74	2155	13	,	,	,
cord-015021-pol2qm74	2155	14	34	34	CD
cord-015021-pol2qm74	2155	15	'	'	POS
cord-015021-pol2qm74	2155	16	5	5	CD
cord-015021-pol2qm74	2155	17	,	,	,
cord-015021-pol2qm74	2155	18	13_+0	13_+0	CD
cord-015021-pol2qm74	2155	19	,	,	,
cord-015021-pol2qm74	2155	20	68'6	68'6	CD
cord-015021-pol2qm74	2155	21	,	,	,
cord-015021-pol2qm74	2155	22	13_+0	13_+0	CD
cord-015021-pol2qm74	2155	23	,	,	,
cord-015021-pol2qm74	2155	24	7	7	CD
cord-015021-pol2qm74	2155	25	"	"	``
cord-015021-pol2qm74	2155	26	7	7	CD
cord-015021-pol2qm74	2155	27	,	,	,
cord-015021-pol2qm74	2155	28	19_+0	19_+0	CD
cord-015021-pol2qm74	2155	29	,	,	,
cord-015021-pol2qm74	2155	30	91	91	CD
cord-015021-pol2qm74	2155	31	"	"	``
cord-015021-pol2qm74	2155	32	kidney	kidney	NN
cord-015021-pol2qm74	2155	33	:	:	:
cord-015021-pol2qm74	2155	34	CrCl	CrCl	NNP
cord-015021-pol2qm74	2155	35	86	86	CD
cord-015021-pol2qm74	2155	36	,	,	,
cord-015021-pol2qm74	2155	37	5+_30	5+_30	NNP
cord-015021-pol2qm74	2155	38	,	,	,
cord-015021-pol2qm74	2155	39	9	9	CD
cord-015021-pol2qm74	2155	40	109	109	CD
cord-015021-pol2qm74	2155	41	,	,	,
cord-015021-pol2qm74	2155	42	[	[	-LRB-
cord-015021-pol2qm74	2155	43	8	8	CD
cord-015021-pol2qm74	2155	44	]	]	-RRB-
cord-015021-pol2qm74	2155	45	[	[	-LRB-
cord-015021-pol2qm74	2155	46	9	9	CD
cord-015021-pol2qm74	2155	47	]	]	-RRB-
cord-015021-pol2qm74	2156	1	[	[	-LRB-
cord-015021-pol2qm74	2156	2	10	10	CD
cord-015021-pol2qm74	2156	3	]	]	-RRB-
cord-015021-pol2qm74	2156	4	[	[	-LRB-
cord-015021-pol2qm74	2156	5	11	11	CD
cord-015021-pol2qm74	2156	6	]	]	-RRB-
cord-015021-pol2qm74	2156	7	[	[	-LRB-
cord-015021-pol2qm74	2156	8	12	12	CD
cord-015021-pol2qm74	2156	9	]	]	-RRB-
cord-015021-pol2qm74	2156	10	[	[	-LRB-
cord-015021-pol2qm74	2156	11	13	13	CD
cord-015021-pol2qm74	2156	12	]	]	-RRB-
cord-015021-pol2qm74	2157	1	[	[	-LRB-
cord-015021-pol2qm74	2157	2	14	14	CD
cord-015021-pol2qm74	2157	3	]	]	-RRB-
cord-015021-pol2qm74	2158	1	[	[	-LRB-
cord-015021-pol2qm74	2158	2	15	15	CD
cord-015021-pol2qm74	2158	3	]	]	-RRB-
cord-015021-pol2qm74	2158	4	[	[	-LRB-
cord-015021-pol2qm74	2158	5	16	16	CD
cord-015021-pol2qm74	2158	6	]	]	-RRB-
cord-015021-pol2qm74	2158	7	[	[	-LRB-
cord-015021-pol2qm74	2158	8	17	17	CD
cord-015021-pol2qm74	2158	9	]	]	-RRB-
cord-015021-pol2qm74	2158	10	[	[	-LRB-
cord-015021-pol2qm74	2158	11	18	18	CD
cord-015021-pol2qm74	2158	12	]	]	-RRB-
cord-015021-pol2qm74	2158	13	[	[	-LRB-
cord-015021-pol2qm74	2158	14	19	19	CD
cord-015021-pol2qm74	2158	15	]	]	-RRB-
cord-015021-pol2qm74	2158	16	4	4	CD
cord-015021-pol2qm74	2158	17	74	74	CD
cord-015021-pol2qm74	2158	18	,	,	,
cord-015021-pol2qm74	2158	19	7_+10	7_+10	CD
cord-015021-pol2qm74	2158	20	,	,	,
cord-015021-pol2qm74	2158	21	868	868	CD
cord-015021-pol2qm74	2158	22	,	,	,
cord-015021-pol2qm74	2158	23	8	8	CD
cord-015021-pol2qm74	2158	24	+	+	SYM
cord-015021-pol2qm74	2158	25	14	14	CD
cord-015021-pol2qm74	2158	26	,	,	,
cord-015021-pol2qm74	2158	27	1	1	CD
cord-015021-pol2qm74	2158	28	53	53	CD
cord-015021-pol2qm74	2158	29	,	,	,
cord-015021-pol2qm74	2158	30	1	1	CD
cord-015021-pol2qm74	2158	31	+	+	SYM
cord-015021-pol2qm74	2158	32	17	17	CD
cord-015021-pol2qm74	2158	33	,	,	,
cord-015021-pol2qm74	2158	34	6	6	CD
cord-015021-pol2qm74	2158	35	Histologic	Histologic	NNP
cord-015021-pol2qm74	2158	36	specimens	specimen	NNS
cord-015021-pol2qm74	2158	37	showed	show	VBD
cord-015021-pol2qm74	2158	38	all	all	DT
cord-015021-pol2qm74	2158	39	signs	sign	NNS
cord-015021-pol2qm74	2158	40	of	of	IN
cord-015021-pol2qm74	2158	41	fulminant	fulminant	JJ
cord-015021-pol2qm74	2158	42	MOF	MOF	NNP
cord-015021-pol2qm74	2158	43	.	.	.
cord-015021-pol2qm74	2159	1	Combination	combination	NN
cord-015021-pol2qm74	2159	2	of	of	IN
cord-015021-pol2qm74	2159	3	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	2159	4	shock	shock	NN
cord-015021-pol2qm74	2159	5	,	,	,
cord-015021-pol2qm74	2159	6	femoral	femoral	JJ
cord-015021-pol2qm74	2159	7	nailing	nailing	NN
cord-015021-pol2qm74	2159	8	,	,	,
cord-015021-pol2qm74	2159	9	ET	ET	NNP
cord-015021-pol2qm74	2159	10	und	und	IN
cord-015021-pol2qm74	2159	11	ZAP	ZAP	NNP
cord-015021-pol2qm74	2159	12	(	(	-LRB-
cord-015021-pol2qm74	2159	13	insults	insult	NNS
cord-015021-pol2qm74	2159	14	in	in	IN
cord-015021-pol2qm74	2159	15	the	the	DT
cord-015021-pol2qm74	2159	16	early	early	JJ
cord-015021-pol2qm74	2159	17	phase	phase	NN
cord-015021-pol2qm74	2159	18	)	)	-RRB-
cord-015021-pol2qm74	2159	19	lead	lead	NN
cord-015021-pol2qm74	2159	20	to	to	IN
cord-015021-pol2qm74	2159	21	an	an	DT
cord-015021-pol2qm74	2159	22	irreversible	irreversible	JJ
cord-015021-pol2qm74	2159	23	organ	organ	NN
cord-015021-pol2qm74	2159	24	failure	failure	NN
cord-015021-pol2qm74	2159	25	in	in	IN
cord-015021-pol2qm74	2159	26	the	the	DT
cord-015021-pol2qm74	2159	27	late	late	JJ
cord-015021-pol2qm74	2159	28	phase	phase	NN
cord-015021-pol2qm74	2159	29	.	.	.
cord-015021-pol2qm74	2160	1	Prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	2160	2	E	e	NN
cord-015021-pol2qm74	2160	3	(	(	-LRB-
cord-015021-pol2qm74	2160	4	PGE	PGE	NNP
cord-015021-pol2qm74	2160	5	)	)	-RRB-
cord-015021-pol2qm74	2160	6	levels	level	NNS
cord-015021-pol2qm74	2160	7	are	be	VBP
cord-015021-pol2qm74	2160	8	elevated	elevate	VBN
cord-015021-pol2qm74	2160	9	by	by	IN
cord-015021-pol2qm74	2160	10	trauma	trauma	NN
cord-015021-pol2qm74	2160	11	,	,	,
cord-015021-pol2qm74	2160	12	shock	shock	NN
cord-015021-pol2qm74	2160	13	or	or	CC
cord-015021-pol2qm74	2160	14	sepsis	sepsis	NN
cord-015021-pol2qm74	2160	15	and	and	CC
cord-015021-pol2qm74	2160	16	can	can	MD
cord-015021-pol2qm74	2160	17	profoundly	profoundly	RB
cord-015021-pol2qm74	2160	18	affect	affect	VB
cord-015021-pol2qm74	2160	19	the	the	DT
cord-015021-pol2qm74	2160	20	immune	immune	JJ
cord-015021-pol2qm74	2160	21	response	response	NN
cord-015021-pol2qm74	2160	22	.	.	.
cord-015021-pol2qm74	2161	1	PGE2	PGE2	NNP
cord-015021-pol2qm74	2161	2	is	be	VBZ
cord-015021-pol2qm74	2161	3	produced	produce	VBN
cord-015021-pol2qm74	2161	4	by	by	IN
cord-015021-pol2qm74	2161	5	many	many	JJ
cord-015021-pol2qm74	2161	6	cell	cell	NN
cord-015021-pol2qm74	2161	7	types	type	NNS
cord-015021-pol2qm74	2161	8	including	include	VBG
cord-015021-pol2qm74	2161	9	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	2161	10	,	,	,
cord-015021-pol2qm74	2161	11	macrophages	macrophage	NNS
cord-015021-pol2qm74	2161	12	,	,	,
cord-015021-pol2qm74	2161	13	monoeytes	monoeyte	NNS
cord-015021-pol2qm74	2161	14	,	,	,
cord-015021-pol2qm74	2161	15	follicular	follicular	JJ
cord-015021-pol2qm74	2161	16	dendritic	dendritic	JJ
cord-015021-pol2qm74	2161	17	cells	cell	NNS
cord-015021-pol2qm74	2161	18	,	,	,
cord-015021-pol2qm74	2161	19	and	and	CC
cord-015021-pol2qm74	2161	20	epithelial	epithelial	JJ
cord-015021-pol2qm74	2161	21	cells	cell	NNS
cord-015021-pol2qm74	2161	22	and	and	CC
cord-015021-pol2qm74	2161	23	is	be	VBZ
cord-015021-pol2qm74	2161	24	induced	induce	VBN
cord-015021-pol2qm74	2161	25	by	by	IN
cord-015021-pol2qm74	2161	26	IL	IL	NNP
cord-015021-pol2qm74	2161	27	-	-	HYPH
cord-015021-pol2qm74	2161	28	I	I	NNP
cord-015021-pol2qm74	2161	29	,	,	,
cord-015021-pol2qm74	2161	30	bacterial	bacterial	JJ
cord-015021-pol2qm74	2161	31	LPS	lp	NNS
cord-015021-pol2qm74	2161	32	,	,	,
cord-015021-pol2qm74	2161	33	components	component	NNS
cord-015021-pol2qm74	2161	34	of	of	IN
cord-015021-pol2qm74	2161	35	the	the	DT
cord-015021-pol2qm74	2161	36	complement	complement	NN
cord-015021-pol2qm74	2161	37	cascade	cascade	NN
cord-015021-pol2qm74	2161	38	,	,	,
cord-015021-pol2qm74	2161	39	TNF	TNF	NNP
cord-015021-pol2qm74	2161	40	,	,	,
cord-015021-pol2qm74	2161	41	IL-6	IL-6	NNP
cord-015021-pol2qm74	2161	42	and	and	CC
cord-015021-pol2qm74	2161	43	crosslinking	crosslinking	NN
cord-015021-pol2qm74	2161	44	of	of	IN
cord-015021-pol2qm74	2161	45	surface	surface	NN
cord-015021-pol2qm74	2161	46	Fc	Fc	NNP
cord-015021-pol2qm74	2161	47	receptors	receptor	NNS
cord-015021-pol2qm74	2161	48	for	for	IN
cord-015021-pol2qm74	2161	49	IgG	IgG	NNP
cord-015021-pol2qm74	2161	50	,	,	,
cord-015021-pol2qm74	2161	51	IgA	IgA	NNP
cord-015021-pol2qm74	2161	52	and	and	CC
cord-015021-pol2qm74	2162	1	IgE.	ige.	NN
cord-015021-pol2qm74	2163	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2163	2	research	research	NN
cord-015021-pol2qm74	2163	3	has	have	VBZ
cord-015021-pol2qm74	2163	4	shown	show	VBN
cord-015021-pol2qm74	2163	5	that	that	IN
cord-015021-pol2qm74	2163	6	PGE	PGE	NNP
cord-015021-pol2qm74	2163	7	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2163	8	B	b	NN
cord-015021-pol2qm74	2163	9	cell	cell	NN
cord-015021-pol2qm74	2163	10	activation	activation	NN
cord-015021-pol2qm74	2163	11	(	(	-LRB-
cord-015021-pol2qm74	2163	12	specifically	specifically	RB
cord-015021-pol2qm74	2163	13	enlargement	enlargement	NN
cord-015021-pol2qm74	2163	14	,	,	,
cord-015021-pol2qm74	2163	15	class	class	NN
cord-015021-pol2qm74	2163	16	II	II	NNP
cord-015021-pol2qm74	2163	17	~C	~C	NFP
cord-015021-pol2qm74	2163	18	and	and	CC
cord-015021-pol2qm74	2163	19	Fc~	Fc~	NNP
cord-015021-pol2qm74	2163	20	RII	RII	NNP
cord-015021-pol2qm74	2163	21	expression	expression	NN
cord-015021-pol2qm74	2163	22	)	)	-RRB-
cord-015021-pol2qm74	2163	23	,	,	,
cord-015021-pol2qm74	2163	24	proliferation	proliferation	NN
cord-015021-pol2qm74	2163	25	,	,	,
cord-015021-pol2qm74	2163	26	IgM	IgM	NNP
cord-015021-pol2qm74	2163	27	and	and	CC
cord-015021-pol2qm74	2163	28	IgG3	IgG3	NNP
cord-015021-pol2qm74	2163	29	responses	response	NNS
cord-015021-pol2qm74	2163	30	,	,	,
cord-015021-pol2qm74	2163	31	T	t	NN
cord-015021-pol2qm74	2163	32	cell	cell	NN
cord-015021-pol2qm74	2163	33	proliferation	proliferation	NN
cord-015021-pol2qm74	2163	34	,	,	,
cord-015021-pol2qm74	2163	35	and	and	CC
cord-015021-pol2qm74	2163	36	IL-2	IL-2	NNP
cord-015021-pol2qm74	2163	37	synthesis	synthesis	NN
cord-015021-pol2qm74	2163	38	in	in	IN
cord-015021-pol2qm74	2163	39	the	the	DT
cord-015021-pol2qm74	2163	40	mouse	mouse	NN
cord-015021-pol2qm74	2163	41	model	model	NN
cord-015021-pol2qm74	2163	42	.	.	.
cord-015021-pol2qm74	2164	1	In	in	IN
cord-015021-pol2qm74	2164	2	contrast	contrast	NN
cord-015021-pol2qm74	2164	3	,	,	,
cord-015021-pol2qm74	2164	4	PGE	PGE	NNP
cord-015021-pol2qm74	2164	5	greatly	greatly	RB
cord-015021-pol2qm74	2164	6	promotes	promote	VBZ
cord-015021-pol2qm74	2164	7	class	class	NN
cord-015021-pol2qm74	2164	8	switching	switch	VBG
cord-015021-pol2qm74	2164	9	to	to	IN
cord-015021-pol2qm74	2164	10	IgE	IgE	NNP
cord-015021-pol2qm74	2164	11	,	,	,
cord-015021-pol2qm74	2164	12	the	the	DT
cord-015021-pol2qm74	2164	13	isotype	isotype	NN
cord-015021-pol2qm74	2164	14	responsible	responsible	JJ
cord-015021-pol2qm74	2164	15	for	for	IN
cord-015021-pol2qm74	2164	16	Type	type	NN
cord-015021-pol2qm74	2164	17	I	-PRON-	PRP
cord-015021-pol2qm74	2164	18	allergic	allergic	JJ
cord-015021-pol2qm74	2164	19	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	2164	20	.	.	.
cord-015021-pol2qm74	2165	1	Thus	thus	RB
cord-015021-pol2qm74	2165	2	,	,	,
cord-015021-pol2qm74	2165	3	our	-PRON-	PRP$
cord-015021-pol2qm74	2165	4	model	model	NN
cord-015021-pol2qm74	2165	5	mirrors	mirror	VBZ
cord-015021-pol2qm74	2165	6	th~	th~	NNP
cord-015021-pol2qm74	2165	7	general	general	JJ
cord-015021-pol2qm74	2165	8	immunosuppression	immunosuppression	NNP
cord-015021-pol2qm74	2165	9	and	and	CC
cord-015021-pol2qm74	2165	10	elevated	elevated	JJ
cord-015021-pol2qm74	2165	11	IgE	IgE	NNP
cord-015021-pol2qm74	2165	12	titers	titer	NNS
cord-015021-pol2qm74	2165	13	of	of	IN
cord-015021-pol2qm74	2165	14	the	the	DT
cord-015021-pol2qm74	2165	15	trauma	trauma	NN
cord-015021-pol2qm74	2165	16	or	or	CC
cord-015021-pol2qm74	2165	17	sepsis	sepsis	NN
cord-015021-pol2qm74	2165	18	patient	patient	NN
cord-015021-pol2qm74	2165	19	.	.	.
cord-015021-pol2qm74	2166	1	PGE	PGE	NNP
cord-015021-pol2qm74	2166	2	increases	increase	VBZ
cord-015021-pol2qm74	2166	3	the	the	DT
cord-015021-pol2qm74	2166	4	number	number	NN
cord-015021-pol2qm74	2166	5	of	of	IN
cord-015021-pol2qm74	2166	6	cells	cell	NNS
cord-015021-pol2qm74	2166	7	secreting	secrete	VBG
cord-015021-pol2qm74	2166	8	IgE	IgE	NNP
cord-015021-pol2qm74	2166	9	and	and	CC
cord-015021-pol2qm74	2166	10	IgGl	IgGl	NNP
cord-015021-pol2qm74	2166	11	,	,	,
cord-015021-pol2qm74	2166	12	acts	act	VBZ
cord-015021-pol2qm74	2166	13	on	on	IN
cord-015021-pol2qm74	2166	14	surface	surface	NN
cord-015021-pol2qm74	2166	15	IgM	IgM	NNP
cord-015021-pol2qm74	2166	16	positive	positive	JJ
cord-015021-pol2qm74	2166	17	B	B	NNP
cord-015021-pol2qm74	2166	18	cells	cell	NNS
cord-015021-pol2qm74	2166	19	,	,	,
cord-015021-pol2qm74	2166	20	synergizes	synergize	VBZ
cord-015021-pol2qm74	2166	21	with	with	IN
cord-015021-pol2qm74	2166	22	IL-4	IL-4	NNP
cord-015021-pol2qm74	2166	23	and	and	CC
cord-015021-pol2qm74	2166	24	LP$	LP$	NNP
cord-015021-pol2qm74	2166	25	to	to	TO
cord-015021-pol2qm74	2166	26	induce	induce	VB
cord-015021-pol2qm74	2166	27	preswitch	preswitch	NN
cord-015021-pol2qm74	2166	28	germline	germline	NN
cord-015021-pol2qm74	2166	29	transcripts	transcript	NNS
cord-015021-pol2qm74	2166	30	,	,	,
cord-015021-pol2qm74	2166	31	and	and	CC
cord-015021-pol2qm74	2166	32	induces	induce	VBZ
cord-015021-pol2qm74	2166	33	more	more	RBR
cord-015021-pol2qm74	2166	34	rapid	rapid	JJ
cord-015021-pol2qm74	2166	35	expression	expression	NN
cord-015021-pol2qm74	2166	36	of	of	IN
cord-015021-pol2qm74	2166	37	mature	mature	JJ
cord-015021-pol2qm74	2166	38	VDJ~	VDJ~	NNP
cord-015021-pol2qm74	2166	39	mP	mP	.
cord-015021-pol2qm74	2167	1	~A	~A	NFP
cord-015021-pol2qm74	2167	2	than	than	IN
cord-015021-pol2qm74	2167	3	in	in	IN
cord-015021-pol2qm74	2167	4	eontro~	eontro~	NNP
cord-015021-pol2qm74	2167	5	PGE	PGE	NNP
cord-015021-pol2qm74	2167	6	intracellular	intracellular	JJ
cord-015021-pol2qm74	2167	7	signalling	signalling	NN
cord-015021-pol2qm74	2167	8	occurs	occur	VBZ
cord-015021-pol2qm74	2167	9	through	through	IN
cord-015021-pol2qm74	2167	10	cyclic	cyclic	JJ
cord-015021-pol2qm74	2167	11	adenosine	adenosine	NN
cord-015021-pol2qm74	2167	12	monophosphate	monophosphate	NN
cord-015021-pol2qm74	2167	13	(	(	-LRB-
cord-015021-pol2qm74	2167	14	cAMP	camp	NN
cord-015021-pol2qm74	2167	15	)	)	-RRB-
cord-015021-pol2qm74	2167	16	levels	level	NNS
cord-015021-pol2qm74	2167	17	and	and	CC
cord-015021-pol2qm74	2167	18	can	can	MD
cord-015021-pol2qm74	2167	19	be	be	VB
cord-015021-pol2qm74	2167	20	mimicked	mimic	VBN
cord-015021-pol2qm74	2167	21	by	by	IN
cord-015021-pol2qm74	2167	22	cAMP	camp	NN
cord-015021-pol2qm74	2167	23	-	-	HYPH
cord-015021-pol2qm74	2167	24	inducing	induce	VBG
cord-015021-pol2qm74	2167	25	agents	agent	NNS
cord-015021-pol2qm74	2167	26	and	and	CC
cord-015021-pol2qm74	2167	27	blocl	blocl	NNS
cord-015021-pol2qm74	2168	1	~ed	~ed	NNP
cord-015021-pol2qm74	2168	2	by	by	IN
cord-015021-pol2qm74	2168	3	an	an	DT
cord-015021-pol2qm74	2168	4	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2168	5	of	of	IN
cord-015021-pol2qm74	2168	6	cAMPdependent	cAMPdependent	NNP
cord-015021-pol2qm74	2168	7	protein	protein	NN
cord-015021-pol2qm74	2168	8	kinase	kinase	NN
cord-015021-pol2qm74	2168	9	A.	A.	NNP
cord-015021-pol2qm74	2168	10	PGE	PGE	NNP
cord-015021-pol2qm74	2168	11	action	action	NN
cord-015021-pol2qm74	2168	12	requires	require	VBZ
cord-015021-pol2qm74	2169	1	de	de	NNP
cord-015021-pol2qm74	2169	2	novo	novo	NNP
cord-015021-pol2qm74	2169	3	protein	protein	NNP
cord-015021-pol2qm74	2169	4	synthesis	synthesis	NN
cord-015021-pol2qm74	2169	5	and	and	CC
cord-015021-pol2qm74	2169	6	candidate	candidate	NN
cord-015021-pol2qm74	2169	7	PGE	PGE	NNP
cord-015021-pol2qm74	2169	8	-	-	HYPH
cord-015021-pol2qm74	2169	9	inducible	inducible	JJ
cord-015021-pol2qm74	2169	10	regulatory	regulatory	JJ
cord-015021-pol2qm74	2169	11	proteins	protein	NNS
cord-015021-pol2qm74	2169	12	have	have	VBP
cord-015021-pol2qm74	2169	13	been	be	VBN
cord-015021-pol2qm74	2169	14	identified	identify	VBN
cord-015021-pol2qm74	2169	15	by	by	IN
cord-015021-pol2qm74	2169	16	2D	2D	NNP
cord-015021-pol2qm74	2169	17	gel	gel	NNP
cord-015021-pol2qm74	2169	18	eleetrophoresis	eleetrophoresis	NNP
cord-015021-pol2qm74	2169	19	.	.	.
cord-015021-pol2qm74	2170	1	Thus	thus	RB
cord-015021-pol2qm74	2170	2	,	,	,
cord-015021-pol2qm74	2170	3	PGE	PGE	NNP
cord-015021-pol2qm74	2170	4	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2170	5	a	a	DT
cord-015021-pol2qm74	2170	6	number	number	NN
cord-015021-pol2qm74	2170	7	of	of	IN
cord-015021-pol2qm74	2170	8	immune	immune	JJ
cord-015021-pol2qm74	2170	9	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2170	10	while	while	IN
cord-015021-pol2qm74	2170	11	promoting	promote	VBG
cord-015021-pol2qm74	2170	12	IgE	IgE	NNP
cord-015021-pol2qm74	2170	13	production	production	NN
cord-015021-pol2qm74	2170	14	.	.	.
cord-015021-pol2qm74	2171	1	A	a	DT
cord-015021-pol2qm74	2171	2	deeper	deep	JJR
cord-015021-pol2qm74	2171	3	understanding	understanding	NN
cord-015021-pol2qm74	2171	4	of	of	IN
cord-015021-pol2qm74	2171	5	PGE	PGE	NNP
cord-015021-pol2qm74	2171	6	immune	immune	JJ
cord-015021-pol2qm74	2171	7	regulation	regulation	NN
cord-015021-pol2qm74	2171	8	may	may	MD
cord-015021-pol2qm74	2171	9	lead	lead	VB
cord-015021-pol2qm74	2171	10	to	to	IN
cord-015021-pol2qm74	2171	11	more	more	RBR
cord-015021-pol2qm74	2171	12	effective	effective	JJ
cord-015021-pol2qm74	2171	13	treatment	treatment	NN
cord-015021-pol2qm74	2171	14	of	of	IN
cord-015021-pol2qm74	2171	15	immune	immune	JJ
cord-015021-pol2qm74	2171	16	perturbations	perturbation	NNS
cord-015021-pol2qm74	2171	17	as	as	IN
cord-015021-pol2qm74	2171	18	sequelae	sequela	NNS
cord-015021-pol2qm74	2171	19	of	of	IN
cord-015021-pol2qm74	2171	20	trauma	trauma	NN
cord-015021-pol2qm74	2171	21	,	,	,
cord-015021-pol2qm74	2171	22	shock	shock	NN
cord-015021-pol2qm74	2171	23	or	or	CC
cord-015021-pol2qm74	2171	24	sepsis	sepsis	NN
cord-015021-pol2qm74	2171	25	.	.	.
cord-015021-pol2qm74	2172	1	During	during	IN
cord-015021-pol2qm74	2172	2	infrarenai	infrarenai	JJ
cord-015021-pol2qm74	2172	3	aortic	aortic	JJ
cord-015021-pol2qm74	2172	4	surgery	surgery	NN
cord-015021-pol2qm74	2172	5	mesetueric	mesetueric	NNP
cord-015021-pol2qm74	2172	6	traction	traction	NN
cord-015021-pol2qm74	2172	7	(	(	-LRB-
cord-015021-pol2qm74	2172	8	re.t	re.t	CD
cord-015021-pol2qm74	2172	9	.	.	.
cord-015021-pol2qm74	2172	10	)	)	-RRB-
cord-015021-pol2qm74	2173	1	results	result	NNS
cord-015021-pol2qm74	2173	2	in	in	IN
cord-015021-pol2qm74	2173	3	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	2173	4	(	(	-LRB-
cord-015021-pol2qm74	2173	5	PGI	PGI	NNP
cord-015021-pol2qm74	2173	6	:	:	:
cord-015021-pol2qm74	2173	7	)	)	-RRB-
cord-015021-pol2qm74	2174	1	release	release	VB
cord-015021-pol2qm74	2174	2	and	and	CC
cord-015021-pol2qm74	2174	3	consecutively	consecutively	RB
cord-015021-pol2qm74	2174	4	in	in	IN
cord-015021-pol2qm74	2174	5	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	2174	6	disturbances	disturbance	NNS
cord-015021-pol2qm74	2174	7	(	(	-LRB-
cord-015021-pol2qm74	2174	8	decreased	decrease	VBD
cord-015021-pol2qm74	2174	9	systemic	systemic	JJ
cord-015021-pol2qm74	2174	10	vascular	vascular	JJ
cord-015021-pol2qm74	2174	11	resisteace	resisteace	NN
cord-015021-pol2qm74	2174	12	,	,	,
cord-015021-pol2qm74	2174	13	mean	mean	VB
cord-015021-pol2qm74	2174	14	arterial	arterial	JJ
cord-015021-pol2qm74	2174	15	pressure	pressure	NN
cord-015021-pol2qm74	2174	16	;	;	,
cord-015021-pol2qm74	2174	17	increased	increase	VBN
cord-015021-pol2qm74	2174	18	cardiac	cardiac	JJ
cord-015021-pol2qm74	2174	19	output	output	NN
cord-015021-pol2qm74	2174	20	,	,	,
cord-015021-pol2qm74	2174	21	heartrate	heartrate	NN
cord-015021-pol2qm74	2174	22	)	)	-RRB-
cord-015021-pol2qm74	2174	23	.	.	.
cord-015021-pol2qm74	2175	1	These	these	DT
cord-015021-pol2qm74	2175	2	symptomes	symptome	NNS
cord-015021-pol2qm74	2175	3	are	be	VBP
cord-015021-pol2qm74	2175	4	bypassed	bypass	VBN
cord-015021-pol2qm74	2175	5	by	by	IN
cord-015021-pol2qm74	2175	6	cyclooxygenase	cyclooxygenase	NN
cord-015021-pol2qm74	2175	7	inhibition	inhibition	NN
cord-015021-pol2qm74	2175	8	.	.	.
cord-015021-pol2qm74	2176	1	Hemodynamic	Hemodynamic	NNP
cord-015021-pol2qm74	2176	2	symptoms	symptom	NNS
cord-015021-pol2qm74	2176	3	vanish	vanish	VBP
cord-015021-pol2qm74	2176	4	after	after	IN
cord-015021-pol2qm74	2176	5	30	30	CD
cord-015021-pol2qm74	2176	6	-	-	SYM
cord-015021-pol2qm74	2176	7	45	45	CD
cord-015021-pol2qm74	2176	8	rain	rain	NN
cord-015021-pol2qm74	2176	9	even	even	RB
cord-015021-pol2qm74	2176	10	without	without	IN
cord-015021-pol2qm74	2176	11	cyclooxygenase	cyclooxygenase	JJ
cord-015021-pol2qm74	2176	12	inhibition	inhibition	NN
cord-015021-pol2qm74	2176	13	although	although	IN
cord-015021-pol2qm74	2176	14	PGI2	PGI2	NNP
cord-015021-pol2qm74	2176	15	levels	level	NNS
cord-015021-pol2qm74	2176	16	remain	remain	VBP
cord-015021-pol2qm74	2176	17	elevated	elevated	JJ
cord-015021-pol2qm74	2176	18	.	.	.
cord-015021-pol2qm74	2177	1	To	to	TO
cord-015021-pol2qm74	2177	2	study	study	VB
cord-015021-pol2qm74	2177	3	the	the	DT
cord-015021-pol2qm74	2177	4	endocrine	endocrine	JJ
cord-015021-pol2qm74	2177	5	vasopressor	vasopressor	NN
cord-015021-pol2qm74	2177	6	system	system	NN
cord-015021-pol2qm74	2177	7	in	in	IN
cord-015021-pol2qm74	2177	8	a	a	DT
cord-015021-pol2qm74	2177	9	prospective	prospective	JJ
cord-015021-pol2qm74	2177	10	double	double	JJ
cord-015021-pol2qm74	2177	11	blinded	blind	VBN
cord-015021-pol2qm74	2177	12	protocol	protocol	NN
cord-015021-pol2qm74	2177	13	,	,	,
cord-015021-pol2qm74	2177	14	we	-PRON-	PRP
cord-015021-pol2qm74	2177	15	investigated	investigate	VBD
cord-015021-pol2qm74	2177	16	26	26	CD
cord-015021-pol2qm74	2177	17	patients	patient	NNS
cord-015021-pol2qm74	2177	18	undergoing	undergo	VBG
cord-015021-pol2qm74	2177	19	major	major	JJ
cord-015021-pol2qm74	2177	20	abdominal	abdominal	JJ
cord-015021-pol2qm74	2177	21	surgery	surgery	NN
cord-015021-pol2qm74	2177	22	as	as	IN
cord-015021-pol2qm74	2177	23	compared	compare	VBN
cord-015021-pol2qm74	2177	24	to	to	IN
cord-015021-pol2qm74	2177	25	26	26	CD
cord-015021-pol2qm74	2177	26	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	2177	27	(	(	-LRB-
cord-015021-pol2qm74	2177	28	400	400	CD
cord-015021-pol2qm74	2177	29	rag	rag	NN
cord-015021-pol2qm74	2177	30	,	,	,
cord-015021-pol2qm74	2177	31	i.v	i.v	NNP
cord-015021-pol2qm74	2177	32	.	.	.
cord-015021-pol2qm74	2177	33	)	)	-RRB-
cord-015021-pol2qm74	2178	1	pretreated	pretreate	VBN
cord-015021-pol2qm74	2178	2	(	(	-LRB-
cord-015021-pol2qm74	2178	3	ibu	ibu	NNP
cord-015021-pol2qm74	2178	4	)	)	-RRB-
cord-015021-pol2qm74	2178	5	patients	patient	NNS
cord-015021-pol2qm74	2178	6	.	.	.
cord-015021-pol2qm74	2179	1	The	the	DT
cord-015021-pol2qm74	2179	2	surgeon	surgeon	NN
cord-015021-pol2qm74	2179	3	applied	apply	VBD
cord-015021-pol2qm74	2179	4	m.t	m.t	NNP
cord-015021-pol2qm74	2179	5	.	.	NNP
cord-015021-pol2qm74	2179	6	in	in	IN
cord-015021-pol2qm74	2179	7	a	a	DT
cord-015021-pol2qm74	2179	8	uniform	uniform	JJ
cord-015021-pol2qm74	2179	9	fashion	fashion	NN
cord-015021-pol2qm74	2179	10	.	.	.
cord-015021-pol2qm74	2180	1	We	-PRON-	PRP
cord-015021-pol2qm74	2180	2	chose	choose	VBD
cord-015021-pol2qm74	2180	3	a	a	DT
cord-015021-pol2qm74	2180	4	general	general	JJ
cord-015021-pol2qm74	2180	5	anesthesia	anesthesia	NN
cord-015021-pol2qm74	2180	6	combined	combine	VBN
cord-015021-pol2qm74	2180	7	with	with	IN
cord-015021-pol2qm74	2180	8	a	a	DT
cord-015021-pol2qm74	2180	9	supplemental	supplemental	JJ
cord-015021-pol2qm74	2180	10	thoracic	thoracic	JJ
cord-015021-pol2qm74	2180	11	epidural	epidural	NN
cord-015021-pol2qm74	2180	12	anesthesia	anesthesia	NN
cord-015021-pol2qm74	2180	13	.	.	.
cord-015021-pol2qm74	2181	1	At	at	IN
cord-015021-pol2qm74	2181	2	the	the	DT
cord-015021-pol2qm74	2181	3	points	point	NNS
cord-015021-pol2qm74	2181	4	in	in	IN
cord-015021-pol2qm74	2181	5	time	time	NN
cord-015021-pol2qm74	2181	6	5	5	CD
cord-015021-pol2qm74	2181	7	,	,	,
cord-015021-pol2qm74	2181	8	15	15	CD
cord-015021-pol2qm74	2181	9	,	,	,
cord-015021-pol2qm74	2181	10	30	30	CD
cord-015021-pol2qm74	2181	11	,	,	,
cord-015021-pol2qm74	2181	12	45	45	CD
cord-015021-pol2qm74	2181	13	,	,	,
cord-015021-pol2qm74	2181	14	90	90	CD
cord-015021-pol2qm74	2181	15	,	,	,
cord-015021-pol2qm74	2181	16	180	180	CD
cord-015021-pol2qm74	2181	17	,	,	,
cord-015021-pol2qm74	2181	18	360	360	CD
cord-015021-pol2qm74	2181	19	,	,	,
cord-015021-pol2qm74	2181	20	1440	1440	CD
cord-015021-pol2qm74	2181	21	rain	rain	NN
cord-015021-pol2qm74	2181	22	after	after	IN
cord-015021-pol2qm74	2181	23	and	and	CC
cord-015021-pol2qm74	2181	24	before	before	RB
cord-015021-pol2qm74	2181	25	(	(	-LRB-
cord-015021-pol2qm74	2181	26	to	to	IN
cord-015021-pol2qm74	2181	27	)	)	-RRB-
cord-015021-pol2qm74	2182	1	mesentzrie	mesentzrie	NNP
cord-015021-pol2qm74	2182	2	traction	traction	NNP
cord-015021-pol2qm74	2183	1	we	-PRON-	PRP
cord-015021-pol2qm74	2183	2	determined	determine	VBD
cord-015021-pol2qm74	2183	3	the	the	DT
cord-015021-pol2qm74	2183	4	plasma	plasma	NN
cord-015021-pol2qm74	2183	5	concentrations	concentration	NNS
cord-015021-pol2qm74	2183	6	(	(	-LRB-
cord-015021-pol2qm74	2183	7	pc	pc	NNP
cord-015021-pol2qm74	2183	8	)	)	-RRB-
cord-015021-pol2qm74	2183	9	of	of	IN
cord-015021-pol2qm74	2183	10	6-keto	6-keto	CD
cord-015021-pol2qm74	2183	11	-	-	HYPH
cord-015021-pol2qm74	2183	12	PGF	PGF	NNP
cord-015021-pol2qm74	2184	1	~o	~o	NFP
cord-015021-pol2qm74	2184	2	~	~	NFP
cord-015021-pol2qm74	2184	3	pr~	pr~	XX
cord-015021-pol2qm74	2184	4	,	,	,
cord-015021-pol2qm74	2184	5	epinephrine	epinephrine	NN
cord-015021-pol2qm74	2184	6	,	,	,
cord-015021-pol2qm74	2184	7	norepinephrine	norepinephrine	NN
cord-015021-pol2qm74	2184	8	,	,	,
cord-015021-pol2qm74	2184	9	dopamine	dopamine	NN
cord-015021-pol2qm74	2184	10	,	,	,
cord-015021-pol2qm74	2184	11	renin	renin	NN
cord-015021-pol2qm74	2184	12	,	,	,
cord-015021-pol2qm74	2184	13	aldosterone	aldosterone	NN
cord-015021-pol2qm74	2184	14	,	,	,
cord-015021-pol2qm74	2184	15	ADH	ADH	NNP
cord-015021-pol2qm74	2184	16	and	and	CC
cord-015021-pol2qm74	2184	17	cortisol	cortisol	NN
cord-015021-pol2qm74	2184	18	.	.	.
cord-015021-pol2qm74	2185	1	Pc	pc	NN
cord-015021-pol2qm74	2185	2	of	of	IN
cord-015021-pol2qm74	2185	3	6-k	6-k	CD
cord-015021-pol2qm74	2185	4	-	-	HYPH
cord-015021-pol2qm74	2185	5	PGF~,tp~	PGF~,tp~	NNPS
cord-015021-pol2qm74	2185	6	,	,	,
cord-015021-pol2qm74	2185	7	peaked	peak	VBD
cord-015021-pol2qm74	2185	8	5	5	CD
cord-015021-pol2qm74	2185	9	minutes	minute	NNS
cord-015021-pol2qm74	2185	10	after	after	IN
cord-015021-pol2qm74	2185	11	m.t	m.t	NNP
cord-015021-pol2qm74	2185	12	.	.	.
cord-015021-pol2qm74	2186	1	(	(	-LRB-
cord-015021-pol2qm74	2186	2	2274_+284	2274_+284	CD
cord-015021-pol2qm74	2186	3	,	,	,
cord-015021-pol2qm74	2186	4	ibu	ibu	NNP
cord-015021-pol2qm74	2186	5	:	:	:
cord-015021-pol2qm74	2186	6	102_+12	102_+12	NNP
cord-015021-pol2qm74	2186	7	,	,	,
cord-015021-pol2qm74	2186	8	to	to	IN
cord-015021-pol2qm74	2186	9	:	:	:
cord-015021-pol2qm74	2186	10	60+I	60+i	CD
cord-015021-pol2qm74	2186	11	ng	ng	NNP
cord-015021-pol2qm74	2186	12	/	/	SYM
cord-015021-pol2qm74	2186	13	l	l	NN
cord-015021-pol2qm74	2186	14	)	)	-RRB-
cord-015021-pol2qm74	2186	15	and	and	CC
cord-015021-pol2qm74	2186	16	declined	decline	VBD
cord-015021-pol2qm74	2186	17	monotonously	monotonously	RB
cord-015021-pol2qm74	2186	18	over	over	IN
cord-015021-pol2qm74	2186	19	6	6	CD
cord-015021-pol2qm74	2186	20	h	h	NN
cord-015021-pol2qm74	2186	21	(	(	-LRB-
cord-015021-pol2qm74	2186	22	203	203	CD
cord-015021-pol2qm74	2186	23	+	+	CC
cord-015021-pol2qm74	2186	24	_	_	NN
cord-015021-pol2qm74	2186	25	42	42	CD
cord-015021-pol2qm74	2186	26	,	,	,
cord-015021-pol2qm74	2186	27	ibu	ibu	NNP
cord-015021-pol2qm74	2186	28	:	:	:
cord-015021-pol2qm74	2186	29	84_+	84_+	CD
cord-015021-pol2qm74	2186	30	12	12	CD
cord-015021-pol2qm74	2186	31	ng/1	ng/1	NNS
cord-015021-pol2qm74	2186	32	)	)	-RRB-
cord-015021-pol2qm74	2186	33	.	.	.
cord-015021-pol2qm74	2187	1	Catecholamine	Catecholamine	NNP
cord-015021-pol2qm74	2187	2	pc	pc	NN
cord-015021-pol2qm74	2187	3	"	"	''
cord-015021-pol2qm74	2187	4	s	s	NN
cord-015021-pol2qm74	2187	5	did	do	VBD
cord-015021-pol2qm74	2187	6	not	not	RB
cord-015021-pol2qm74	2187	7	exceed	exceed	VB
cord-015021-pol2qm74	2187	8	the	the	DT
cord-015021-pol2qm74	2187	9	reference	reference	NN
cord-015021-pol2qm74	2187	10	range	range	NN
cord-015021-pol2qm74	2187	11	during	during	IN
cord-015021-pol2qm74	2187	12	the	the	DT
cord-015021-pol2qm74	2187	13	observation	observation	NN
cord-015021-pol2qm74	2187	14	period	period	NN
cord-015021-pol2qm74	2187	15	.	.	.
cord-015021-pol2qm74	2188	1	Reninpc	Reninpc	NNP
cord-015021-pol2qm74	2188	2	peaked	peak	VBD
cord-015021-pol2qm74	2188	3	after	after	IN
cord-015021-pol2qm74	2188	4	45	45	CD
cord-015021-pol2qm74	2188	5	rain	rain	NN
cord-015021-pol2qm74	2188	6	(	(	-LRB-
cord-015021-pol2qm74	2188	7	66_+23	66_+23	CD
cord-015021-pol2qm74	2188	8	,	,	,
cord-015021-pol2qm74	2188	9	ibu	ibu	NN
cord-015021-pol2qm74	2188	10	:	:	:
cord-015021-pol2qm74	2189	1	18	18	CD
cord-015021-pol2qm74	2189	2	+	+	SYM
cord-015021-pol2qm74	2189	3	3	3	CD
cord-015021-pol2qm74	2189	4	,	,	,
cord-015021-pol2qm74	2189	5	to	to	IN
cord-015021-pol2qm74	2189	6	:	:	:
cord-015021-pol2qm74	2189	7	16-+2/~U	16-+2/~u	LS
cord-015021-pol2qm74	2189	8	/	/	SYM
cord-015021-pol2qm74	2189	9	ml	ml	NN
cord-015021-pol2qm74	2189	10	)	)	-RRB-
cord-015021-pol2qm74	2189	11	;	;	:
cord-015021-pol2qm74	2189	12	aldosteronc	aldosteronc	NNP
cord-015021-pol2qm74	2189	13	also	also	RB
cord-015021-pol2qm74	2189	14	presented	present	VBD
cord-015021-pol2qm74	2189	15	a	a	DT
cord-015021-pol2qm74	2189	16	maximum	maximum	NN
cord-015021-pol2qm74	2189	17	after	after	IN
cord-015021-pol2qm74	2189	18	45	45	CD
cord-015021-pol2qm74	2189	19	rain	rain	NN
cord-015021-pol2qm74	2189	20	(	(	-LRB-
cord-015021-pol2qm74	2189	21	110	110	CD
cord-015021-pol2qm74	2189	22	+	+	SYM
cord-015021-pol2qm74	2189	23	12	12	CD
cord-015021-pol2qm74	2189	24	,	,	,
cord-015021-pol2qm74	2189	25	ibu	ibu	NNP
cord-015021-pol2qm74	2189	26	:	:	:
cord-015021-pol2qm74	2189	27	66-+	66-+	CD
cord-015021-pol2qm74	2189	28	15	15	CD
cord-015021-pol2qm74	2189	29	,	,	,
cord-015021-pol2qm74	2189	30	to	to	IN
cord-015021-pol2qm74	2189	31	:	:	:
cord-015021-pol2qm74	2189	32	56	56	CD
cord-015021-pol2qm74	2189	33	+	+	SYM
cord-015021-pol2qm74	2189	34	-7	-7	CD
cord-015021-pol2qm74	2189	35	pg	pg	NNP
cord-015021-pol2qm74	2189	36	/	/	SYM
cord-015021-pol2qm74	2189	37	ml	ml	NNP
cord-015021-pol2qm74	2189	38	)	)	-RRB-
cord-015021-pol2qm74	2189	39	,	,	,
cord-015021-pol2qm74	2189	40	whereas	whereas	IN
cord-015021-pol2qm74	2189	41	cortisol	cortisol	NN
cord-015021-pol2qm74	2189	42	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	2189	43	irrespectively	irrespectively	RB
cord-015021-pol2qm74	2189	44	of	of	IN
cord-015021-pol2qm74	2189	45	circadian	circadian	NN
cord-015021-pol2qm74	2189	46	rhythms	rhythm	VBZ
cord-015021-pol2qm74	2189	47	a	a	DT
cord-015021-pol2qm74	2189	48	maximum	maximum	JJ
cord-015021-pol2qm74	2189	49	6	6	CD
cord-015021-pol2qm74	2189	50	h	h	NN
cord-015021-pol2qm74	2189	51	after	after	IN
cord-015021-pol2qm74	2189	52	m.t	m.t	NNP
cord-015021-pol2qm74	2189	53	.	.	.
cord-015021-pol2qm74	2190	1	(	(	-LRB-
cord-015021-pol2qm74	2190	2	26+_1	26+_1	CD
cord-015021-pol2qm74	2190	3	,	,	,
cord-015021-pol2qm74	2190	4	ibu	ibu	NNP
cord-015021-pol2qm74	2190	5	:	:	:
cord-015021-pol2qm74	2190	6	24-+3	24-+3	CD
cord-015021-pol2qm74	2190	7	,	,	,
cord-015021-pol2qm74	2190	8	to	to	IN
cord-015021-pol2qm74	2190	9	:	:	:
cord-015021-pol2qm74	2190	10	10+_1	10+_1	CD
cord-015021-pol2qm74	2190	11	~g/1	~g/1	NFP
cord-015021-pol2qm74	2190	12	)	)	-RRB-
cord-015021-pol2qm74	2190	13	.	.	.
cord-015021-pol2qm74	2191	1	ADH	ADH	NNP
cord-015021-pol2qm74	2191	2	pc	pc	NN
cord-015021-pol2qm74	2191	3	peaked	peak	VBD
cord-015021-pol2qm74	2191	4	5	5	CD
cord-015021-pol2qm74	2191	5	min	min	NN
cord-015021-pol2qm74	2191	6	after	after	IN
cord-015021-pol2qm74	2191	7	m.t	m.t	NNP
cord-015021-pol2qm74	2191	8	.	.	.
cord-015021-pol2qm74	2192	1	(	(	-LRB-
cord-015021-pol2qm74	2192	2	71	71	CD
cord-015021-pol2qm74	2192	3	+	+	SYM
cord-015021-pol2qm74	2192	4	7	7	CD
cord-015021-pol2qm74	2192	5	,	,	,
cord-015021-pol2qm74	2192	6	ibu	ibu	NNP
cord-015021-pol2qm74	2192	7	:	:	:
cord-015021-pol2qm74	2193	1	20-+6	20-+6	CD
cord-015021-pol2qm74	2193	2	,	,	,
cord-015021-pol2qm74	2193	3	to	to	IN
cord-015021-pol2qm74	2193	4	:	:	:
cord-015021-pol2qm74	2193	5	5+_1	5+_1	CD
cord-015021-pol2qm74	2193	6	pg	pg	NNP
cord-015021-pol2qm74	2193	7	/	/	SYM
cord-015021-pol2qm74	2193	8	ml	ml	NNP
cord-015021-pol2qm74	2193	9	)	)	-RRB-
cord-015021-pol2qm74	2193	10	and	and	CC
cord-015021-pol2qm74	2193	11	showed	show	VBD
cord-015021-pol2qm74	2193	12	analogously	analogously	RB
cord-015021-pol2qm74	2193	13	to	to	IN
cord-015021-pol2qm74	2193	14	6-k	6-k	CD
cord-015021-pol2qm74	2193	15	-	-	HYPH
cord-015021-pol2qm74	2193	16	PGFt	PGFt	NNS
cord-015021-pol2qm74	2193	17	~	~	NFP
cord-015021-pol2qm74	2193	18	j~	j~	UH
cord-015021-pol2qm74	2193	19	pc	pc	VB
cord-015021-pol2qm74	2193	20	a	a	DT
cord-015021-pol2qm74	2193	21	monotone	monotone	JJ
cord-015021-pol2qm74	2193	22	decline	decline	NN
cord-015021-pol2qm74	2193	23	over	over	IN
cord-015021-pol2qm74	2193	24	the	the	DT
cord-015021-pol2qm74	2193	25	observation	observation	NN
cord-015021-pol2qm74	2193	26	period	period	NN
cord-015021-pol2qm74	2193	27	.	.	.
cord-015021-pol2qm74	2194	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2194	2	data	datum	NNS
cord-015021-pol2qm74	2194	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2194	4	a	a	DT
cord-015021-pol2qm74	2194	5	counteractive	counteractive	JJ
cord-015021-pol2qm74	2194	6	reaction	reaction	NN
cord-015021-pol2qm74	2194	7	to	to	IN
cord-015021-pol2qm74	2194	8	PGIz	PGIz	NNS
cord-015021-pol2qm74	2194	9	mediated	mediate	VBN
cord-015021-pol2qm74	2194	10	vasodilation	vasodilation	NN
cord-015021-pol2qm74	2194	11	via	via	IN
cord-015021-pol2qm74	2194	12	ADH	ADH	NNP
cord-015021-pol2qm74	2194	13	secretion	secretion	NN
cord-015021-pol2qm74	2194	14	.	.	.
cord-015021-pol2qm74	2195	1	The	the	DT
cord-015021-pol2qm74	2195	2	second	second	JJ
cord-015021-pol2qm74	2195	3	regulative	regulative	NN
cord-015021-pol2qm74	2195	4	is	be	VBZ
cord-015021-pol2qm74	2195	5	the	the	DT
cord-015021-pol2qm74	2195	6	renin	renin	NN
cord-015021-pol2qm74	2195	7	-	-	HYPH
cord-015021-pol2qm74	2195	8	angiotensin	angiotensin	NN
cord-015021-pol2qm74	2195	9	-	-	HYPH
cord-015021-pol2qm74	2195	10	aldosterone	aldosterone	NN
cord-015021-pol2qm74	2195	11	system	system	NN
cord-015021-pol2qm74	2195	12	(	(	-LRB-
cord-015021-pol2qm74	2195	13	RAAS	RAAS	NNP
cord-015021-pol2qm74	2195	14	)	)	-RRB-
cord-015021-pol2qm74	2195	15	,	,	,
cord-015021-pol2qm74	2195	16	which	which	WDT
cord-015021-pol2qm74	2195	17	is	be	VBZ
cord-015021-pol2qm74	2195	18	activated	activate	VBN
cord-015021-pol2qm74	2195	19	45	45	CD
cord-015021-pol2qm74	2195	20	min	min	NN
cord-015021-pol2qm74	2195	21	after	after	IN
cord-015021-pol2qm74	2195	22	m.t	m.t	NNP
cord-015021-pol2qm74	2195	23	.	.	NNP
cord-015021-pol2qm74	2195	24	,	,	,
cord-015021-pol2qm74	2195	25	the	the	DT
cord-015021-pol2qm74	2195	26	aldosterone	aldosterone	NN
cord-015021-pol2qm74	2195	27	pc	pc	NN
cord-015021-pol2qm74	2195	28	does	do	VBZ
cord-015021-pol2qm74	2195	29	not	not	RB
cord-015021-pol2qm74	2195	30	paratlel	paratlel	VBZ
cord-015021-pol2qm74	2195	31	the	the	DT
cord-015021-pol2qm74	2195	32	cortisol	cortisol	NN
cord-015021-pol2qm74	2195	33	pc	pc	NN
cord-015021-pol2qm74	2195	34	,	,	,
cord-015021-pol2qm74	2195	35	which	which	WDT
cord-015021-pol2qm74	2195	36	peaked	peak	VBD
cord-015021-pol2qm74	2195	37	post	post	NN
cord-015021-pol2qm74	2195	38	operafionem	operafionem	NN
cord-015021-pol2qm74	2195	39	in	in	IN
cord-015021-pol2qm74	2195	40	both	both	DT
cord-015021-pol2qm74	2195	41	groups	group	NNS
cord-015021-pol2qm74	2195	42	,	,	,
cord-015021-pol2qm74	2195	43	probably	probably	RB
cord-015021-pol2qm74	2195	44	due	due	IN
cord-015021-pol2qm74	2195	45	to	to	IN
cord-015021-pol2qm74	2195	46	the	the	DT
cord-015021-pol2qm74	2195	47	end	end	NN
cord-015021-pol2qm74	2195	48	of	of	IN
cord-015021-pol2qm74	2195	49	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	2195	50	.	.	.
cord-015021-pol2qm74	2196	1	A	a	DT
cord-015021-pol2qm74	2196	2	regulative	regulative	JJ
cord-015021-pol2qm74	2196	3	release	release	NN
cord-015021-pol2qm74	2196	4	of	of	IN
cord-015021-pol2qm74	2196	5	catecholamines	catecholamine	NNS
cord-015021-pol2qm74	2196	6	could	could	MD
cord-015021-pol2qm74	2196	7	not	not	RB
cord-015021-pol2qm74	2196	8	be	be	VB
cord-015021-pol2qm74	2196	9	documented	document	VBN
cord-015021-pol2qm74	2196	10	.	.	.
cord-015021-pol2qm74	2197	1	The	the	DT
cord-015021-pol2qm74	2197	2	activation	activation	NN
cord-015021-pol2qm74	2197	3	of	of	IN
cord-015021-pol2qm74	2197	4	ADH	ADH	NNP
cord-015021-pol2qm74	2197	5	and	and	CC
cord-015021-pol2qm74	2197	6	RAAS	RAAS	NNP
cord-015021-pol2qm74	2197	7	after	after	IN
cord-015021-pol2qm74	2197	8	MT	MT	NNP
cord-015021-pol2qm74	2197	9	is	be	VBZ
cord-015021-pol2qm74	2197	10	not	not	RB
cord-015021-pol2qm74	2197	11	a	a	DT
cord-015021-pol2qm74	2197	12	hormonal	hormonal	JJ
cord-015021-pol2qm74	2197	13	response	response	NN
cord-015021-pol2qm74	2197	14	primaryly	primaryly	NN
cord-015021-pol2qm74	2197	15	related	relate	VBN
cord-015021-pol2qm74	2197	16	to	to	IN
cord-015021-pol2qm74	2197	17	surgical	surgical	JJ
cord-015021-pol2qm74	2197	18	trauma	trauma	NN
cord-015021-pol2qm74	2197	19	and/or	and/or	CC
cord-015021-pol2qm74	2197	20	stress	stress	NN
cord-015021-pol2qm74	2197	21	but	but	CC
cord-015021-pol2qm74	2197	22	a	a	DT
cord-015021-pol2qm74	2197	23	counterregulation	counterregulation	NN
cord-015021-pol2qm74	2197	24	to	to	IN
cord-015021-pol2qm74	2197	25	systemic	systemic	JJ
cord-015021-pol2qm74	2197	26	vasoditafion	vasoditafion	NN
cord-015021-pol2qm74	2197	27	induced	induce	VBN
cord-015021-pol2qm74	2197	28	by	by	IN
cord-015021-pol2qm74	2197	29	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	2197	30	.	.	.
cord-015021-pol2qm74	2198	1	Although	although	IN
cord-015021-pol2qm74	2198	2	ADH	ADH	NNP
cord-015021-pol2qm74	2198	3	and	and	CC
cord-015021-pol2qm74	2198	4	RAAS	RAAS	NNP
cord-015021-pol2qm74	2198	5	support	support	VBP
cord-015021-pol2qm74	2198	6	systemic	systemic	JJ
cord-015021-pol2qm74	2198	7	circulation	circulation	NN
cord-015021-pol2qm74	2198	8	,	,	,
cord-015021-pol2qm74	2198	9	angiotensin	angiotensin	NN
cord-015021-pol2qm74	2198	10	and	and	CC
cord-015021-pol2qm74	2198	11	vasopressin	vasopressin	NN
cord-015021-pol2qm74	2198	12	may	may	MD
cord-015021-pol2qm74	2198	13	compromise	compromise	VB
cord-015021-pol2qm74	2198	14	local	local	JJ
cord-015021-pol2qm74	2198	15	organ	organ	NN
cord-015021-pol2qm74	2198	16	blood	blood	NN
cord-015021-pol2qm74	2198	17	flow	flow	NN
cord-015021-pol2qm74	2198	18	(	(	-LRB-
cord-015021-pol2qm74	2199	1	e.g.	e.g.	IN
cord-015021-pol2qm74	2199	2	splancimic	splancimic	JJ
cord-015021-pol2qm74	2199	3	vascular	vascular	JJ
cord-015021-pol2qm74	2199	4	bed	bed	NN
cord-015021-pol2qm74	2199	5	)	)	-RRB-
cord-015021-pol2qm74	2199	6	.	.	.
cord-015021-pol2qm74	2200	1	Insfitut	Insfitut	NNP
cord-015021-pol2qm74	2200	2	f.	f.	NN
cord-015021-pol2qm74	2200	3	Klin	Klin	NNP
cord-015021-pol2qm74	2200	4	.	.	.
cord-015021-pol2qm74	2201	1	Chemic	Chemic	NNP
cord-015021-pol2qm74	2201	2	,	,	,
cord-015021-pol2qm74	2201	3	Anaesthesiologie	Anaesthesiologie	NNP
cord-015021-pol2qm74	2201	4	~	~	NFP
cord-015021-pol2qm74	2201	5	,	,	,
cord-015021-pol2qm74	2201	6	Chirurgie	Chirurgie	NNP
cord-015021-pol2qm74	2201	7	l	l	NNP
cord-015021-pol2qm74	2201	8	*	*	NFP
cord-015021-pol2qm74	2201	9	,	,	,
cord-015021-pol2qm74	2201	10	Univ	Univ	NNP
cord-015021-pol2qm74	2201	11	.	.	.
cord-015021-pol2qm74	2202	1	Ulm	Ulm	NNP
cord-015021-pol2qm74	2202	2	,	,	,
cord-015021-pol2qm74	2202	3	89070	89070	CD
cord-015021-pol2qm74	2202	4	Elm	Elm	NNP
cord-015021-pol2qm74	2202	5	,	,	,
cord-015021-pol2qm74	2202	6	Expression	expression	NN
cord-015021-pol2qm74	2202	7	of	of	IN
cord-015021-pol2qm74	2202	8	c	c	NNP
cord-015021-pol2qm74	2202	9	-	-	HYPH
cord-015021-pol2qm74	2202	10	fos	fos	NNP
cord-015021-pol2qm74	2202	11	protein	protein	NN
cord-015021-pol2qm74	2202	12	in	in	IN
cord-015021-pol2qm74	2202	13	rat	rat	NN
cord-015021-pol2qm74	2202	14	brain	brain	NN
cord-015021-pol2qm74	2202	15	following	follow	VBG
cord-015021-pol2qm74	2202	16	occlusion	occlusion	NN
cord-015021-pol2qm74	2202	17	of	of	IN
cord-015021-pol2qm74	2202	18	superior	superior	JJ
cord-015021-pol2qm74	2202	19	mesenterie	mesenterie	NNP
cord-015021-pol2qm74	2202	20	artery	artery	NN
cord-015021-pol2qm74	2202	21	.	.	.
cord-015021-pol2qm74	2203	1	Takanobu	Takanobu	NNP
cord-015021-pol2qm74	2203	2	There	there	EX
cord-015021-pol2qm74	2203	3	is	be	VBZ
cord-015021-pol2qm74	2203	4	general	general	JJ
cord-015021-pol2qm74	2203	5	agreement	agreement	NN
cord-015021-pol2qm74	2203	6	that	that	WDT
cord-015021-pol2qm74	2203	7	neurologic	neurologic	JJ
cord-015021-pol2qm74	2203	8	abnormalities	abnormality	NNS
cord-015021-pol2qm74	2203	9	are	be	VBP
cord-015021-pol2qm74	2203	10	seen	see	VBN
cord-015021-pol2qm74	2203	11	in	in	IN
cord-015021-pol2qm74	2203	12	sepsis	sepsis	NN
cord-015021-pol2qm74	2203	13	.	.	.
cord-015021-pol2qm74	2204	1	The	the	DT
cord-015021-pol2qm74	2204	2	aim	aim	NN
cord-015021-pol2qm74	2204	3	of	of	IN
cord-015021-pol2qm74	2204	4	this	this	DT
cord-015021-pol2qm74	2204	5	study	study	NN
cord-015021-pol2qm74	2204	6	is	be	VBZ
cord-015021-pol2qm74	2204	7	to	to	TO
cord-015021-pol2qm74	2204	8	examine	examine	VB
cord-015021-pol2qm74	2204	9	what	what	WDT
cord-015021-pol2qm74	2204	10	effect	effect	NN
cord-015021-pol2qm74	2204	11	does	do	VBZ
cord-015021-pol2qm74	2204	12	the	the	DT
cord-015021-pol2qm74	2204	13	brain	brain	NN
cord-015021-pol2qm74	2204	14	receive	receive	VB
cord-015021-pol2qm74	2204	15	in	in	IN
cord-015021-pol2qm74	2204	16	case	case	NN
cord-015021-pol2qm74	2204	17	of	of	IN
cord-015021-pol2qm74	2204	18	SMA	SMA	NNP
cord-015021-pol2qm74	2204	19	occlusion	occlusion	NN
cord-015021-pol2qm74	2204	20	by	by	IN
cord-015021-pol2qm74	2204	21	immunohistochemistry	immunohistochemistry	NN
cord-015021-pol2qm74	2204	22	using	use	VBG
cord-015021-pol2qm74	2204	23	antibody	antibody	NN
cord-015021-pol2qm74	2204	24	to	to	IN
cord-015021-pol2qm74	2204	25	c	c	NNP
cord-015021-pol2qm74	2204	26	-	-	HYPH
cord-015021-pol2qm74	2204	27	fos	fos	NNP
cord-015021-pol2qm74	2204	28	,	,	,
cord-015021-pol2qm74	2204	29	an	an	DT
cord-015021-pol2qm74	2204	30	immediate	immediate	JJ
cord-015021-pol2qm74	2204	31	early	early	JJ
cord-015021-pol2qm74	2204	32	gene	gene	NN
cord-015021-pol2qm74	2204	33	,	,	,
cord-015021-pol2qm74	2204	34	which	which	WDT
cord-015021-pol2qm74	2204	35	is	be	VBZ
cord-015021-pol2qm74	2204	36	recently	recently	RB
cord-015021-pol2qm74	2204	37	recognized	recognize	VBN
cord-015021-pol2qm74	2204	38	as	as	IN
cord-015021-pol2qm74	2204	39	a	a	DT
cord-015021-pol2qm74	2204	40	genetic	genetic	JJ
cord-015021-pol2qm74	2204	41	marker	marker	NN
cord-015021-pol2qm74	2204	42	of	of	IN
cord-015021-pol2qm74	2204	43	activated	activate	VBN
cord-015021-pol2qm74	2204	44	neurons	neuron	NNS
cord-015021-pol2qm74	2204	45	.	.	.
cord-015021-pol2qm74	2205	1	Moreover	moreover	RB
cord-015021-pol2qm74	2205	2	,	,	,
cord-015021-pol2qm74	2205	3	we	-PRON-	PRP
cord-015021-pol2qm74	2205	4	investigated	investigate	VBD
cord-015021-pol2qm74	2205	5	the	the	DT
cord-015021-pol2qm74	2205	6	correlation	correlation	NN
cord-015021-pol2qm74	2205	7	between	between	IN
cord-015021-pol2qm74	2205	8	c	c	NNP
cord-015021-pol2qm74	2205	9	-	-	HYPH
cord-015021-pol2qm74	2205	10	fos	fos	NNP
cord-015021-pol2qm74	2205	11	induction	induction	NN
cord-015021-pol2qm74	2205	12	in	in	IN
cord-015021-pol2qm74	2205	13	the	the	DT
cord-015021-pol2qm74	2205	14	brain	brain	NN
cord-015021-pol2qm74	2205	15	and	and	CC
cord-015021-pol2qm74	2205	16	plasma	plasma	NN
cord-015021-pol2qm74	2205	17	endotoxiu	endotoxiu	JJ
cord-015021-pol2qm74	2205	18	level	level	NN
cord-015021-pol2qm74	2205	19	.	.	.
cord-015021-pol2qm74	2206	1	20	20	CD
cord-015021-pol2qm74	2206	2	rats	rat	NNS
cord-015021-pol2qm74	2206	3	of	of	IN
cord-015021-pol2qm74	2206	4	them	-PRON-	PRP
cord-015021-pol2qm74	2206	5	received	receive	VBD
cord-015021-pol2qm74	2206	6	SMA	SMA	NNP
cord-015021-pol2qm74	2206	7	clipping	clip	VBG
cord-015021-pol2qm74	2206	8	and	and	CC
cord-015021-pol2qm74	2206	9	others	other	NNS
cord-015021-pol2qm74	2206	10	wee	wee	VBP
cord-015021-pol2qm74	2206	11	used	use	VBN
cord-015021-pol2qm74	2206	12	as	as	IN
cord-015021-pol2qm74	2206	13	control	control	NN
cord-015021-pol2qm74	2206	14	.	.	.
cord-015021-pol2qm74	2207	1	Control	control	NN
cord-015021-pol2qm74	2207	2	and	and	CC
cord-015021-pol2qm74	2207	3	treated	treat	VBD
cord-015021-pol2qm74	2207	4	rats	rat	NNS
cord-015021-pol2qm74	2207	5	at	at	IN
cord-015021-pol2qm74	2207	6	2	2	CD
cord-015021-pol2qm74	2207	7	,	,	,
cord-015021-pol2qm74	2207	8	4	4	CD
cord-015021-pol2qm74	2207	9	,	,	,
cord-015021-pol2qm74	2207	10	6	6	CD
cord-015021-pol2qm74	2207	11	,	,	,
cord-015021-pol2qm74	2207	12	8	8	CD
cord-015021-pol2qm74	2207	13	hours	hour	NNS
cord-015021-pol2qm74	2207	14	were	be	VBD
cord-015021-pol2qm74	2207	15	perfused	perfuse	VBN
cord-015021-pol2qm74	2207	16	and	and	CC
cord-015021-pol2qm74	2207	17	fixed	fix	VBN
cord-015021-pol2qm74	2207	18	.	.	.
cord-015021-pol2qm74	2208	1	The	the	DT
cord-015021-pol2qm74	2208	2	brain	brain	NN
cord-015021-pol2qm74	2208	3	were	be	VBD
cord-015021-pol2qm74	2208	4	sectioned	section	VBN
cord-015021-pol2qm74	2208	5	at	at	IN
cord-015021-pol2qm74	2208	6	20	20	CD
cord-015021-pol2qm74	2208	7	pm	pm	NN
cord-015021-pol2qm74	2208	8	and	and	CC
cord-015021-pol2qm74	2208	9	stained	stain	VBN
cord-015021-pol2qm74	2208	10	by	by	IN
cord-015021-pol2qm74	2208	11	ABC	ABC	NNP
cord-015021-pol2qm74	2208	12	method	method	NN
cord-015021-pol2qm74	2208	13	using	use	VBG
cord-015021-pol2qm74	2208	14	c	c	NN
cord-015021-pol2qm74	2208	15	-	-	HYPH
cord-015021-pol2qm74	2208	16	fos	fos	NNP
cord-015021-pol2qm74	2208	17	antibody	antibody	NN
cord-015021-pol2qm74	2208	18	.	.	.
cord-015021-pol2qm74	2209	1	Plasma	plasma	NN
cord-015021-pol2qm74	2209	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2209	3	level	level	NN
cord-015021-pol2qm74	2209	4	of	of	IN
cord-015021-pol2qm74	2209	5	5	5	CD
cord-015021-pol2qm74	2209	6	rats	rat	NNS
cord-015021-pol2qm74	2209	7	were	be	VBD
cord-015021-pol2qm74	2209	8	measured	measure	VBN
cord-015021-pol2qm74	2209	9	at	at	IN
cord-015021-pol2qm74	2209	10	0	0	CD
cord-015021-pol2qm74	2209	11	,	,	,
cord-015021-pol2qm74	2209	12	2	2	CD
cord-015021-pol2qm74	2209	13	,	,	,
cord-015021-pol2qm74	2209	14	4	4	CD
cord-015021-pol2qm74	2209	15	,	,	,
cord-015021-pol2qm74	2209	16	6	6	CD
cord-015021-pol2qm74	2209	17	,	,	,
cord-015021-pol2qm74	2209	18	8	8	CD
cord-015021-pol2qm74	2209	19	hours	hour	NNS
cord-015021-pol2qm74	2209	20	after	after	IN
cord-015021-pol2qm74	2209	21	the	the	DT
cord-015021-pol2qm74	2209	22	treatment	treatment	NN
cord-015021-pol2qm74	2209	23	by	by	IN
cord-015021-pol2qm74	2209	24	chromogenic	chromogenic	NNP
cord-015021-pol2qm74	2209	25	limulus	limulus	NNP
cord-015021-pol2qm74	2209	26	method	method	NN
cord-015021-pol2qm74	2209	27	.	.	.
cord-015021-pol2qm74	2210	1	Immunohistochemical	Immunohistochemical	NNP
cord-015021-pol2qm74	2210	2	study	study	NN
cord-015021-pol2qm74	2210	3	showed	show	VBD
cord-015021-pol2qm74	2210	4	scarcely	scarcely	RB
cord-015021-pol2qm74	2210	5	no	no	DT
cord-015021-pol2qm74	2210	6	immunoreactivity	immunoreactivity	NN
cord-015021-pol2qm74	2210	7	in	in	IN
cord-015021-pol2qm74	2210	8	control	control	NN
cord-015021-pol2qm74	2210	9	rat	rat	NN
cord-015021-pol2qm74	2210	10	brain	brain	NN
cord-015021-pol2qm74	2210	11	.	.	.
cord-015021-pol2qm74	2211	1	In	in	IN
cord-015021-pol2qm74	2211	2	treated	treated	JJ
cord-015021-pol2qm74	2211	3	rat	rat	NN
cord-015021-pol2qm74	2211	4	brain	brain	NN
cord-015021-pol2qm74	2211	5	,	,	,
cord-015021-pol2qm74	2211	6	the	the	DT
cord-015021-pol2qm74	2211	7	significant	significant	JJ
cord-015021-pol2qm74	2211	8	expression	expression	NN
cord-015021-pol2qm74	2211	9	of	of	IN
cord-015021-pol2qm74	2211	10	c	c	NNP
cord-015021-pol2qm74	2211	11	-	-	:
cord-015021-pol2qm74	2211	12	los	los	NNP
cord-015021-pol2qm74	2211	13	was	be	VBD
cord-015021-pol2qm74	2211	14	detected	detect	VBN
cord-015021-pol2qm74	2211	15	in	in	IN
cord-015021-pol2qm74	2211	16	specific	specific	JJ
cord-015021-pol2qm74	2211	17	nuclei	nucleus	NNS
cord-015021-pol2qm74	2211	18	including	include	VBG
cord-015021-pol2qm74	2211	19	the	the	DT
cord-015021-pol2qm74	2211	20	habenula	habenula	NN
cord-015021-pol2qm74	2211	21	,	,	,
cord-015021-pol2qm74	2211	22	some	some	DT
cord-015021-pol2qm74	2211	23	hypothalamie	hypothalamie	NNP
cord-015021-pol2qm74	2211	24	nuclei	nucleus	NNS
cord-015021-pol2qm74	2211	25	,	,	,
cord-015021-pol2qm74	2211	26	amygdala	amygdala	NN
cord-015021-pol2qm74	2211	27	,	,	,
cord-015021-pol2qm74	2211	28	locus	locus	NN
cord-015021-pol2qm74	2211	29	ceruleus	ceruleu	NNS
cord-015021-pol2qm74	2211	30	and	and	CC
cord-015021-pol2qm74	2211	31	nucleus	nucleus	NN
cord-015021-pol2qm74	2211	32	tractus	tractus	NNP
cord-015021-pol2qm74	2211	33	solitarii	solitarii	NNP
cord-015021-pol2qm74	2211	34	.	.	.
cord-015021-pol2qm74	2212	1	Such	such	JJ
cord-015021-pol2qm74	2212	2	immunoreactivities	immunoreactivitie	NNS
cord-015021-pol2qm74	2212	3	were	be	VBD
cord-015021-pol2qm74	2212	4	increased	increase	VBN
cord-015021-pol2qm74	2212	5	in	in	IN
cord-015021-pol2qm74	2212	6	time	time	NN
cord-015021-pol2qm74	2212	7	curse	curse	NN
cord-015021-pol2qm74	2212	8	,	,	,
cord-015021-pol2qm74	2212	9	which	which	WDT
cord-015021-pol2qm74	2212	10	well	well	RB
cord-015021-pol2qm74	2212	11	corresponded	correspond	VBD
cord-015021-pol2qm74	2212	12	plasma	plasma	NN
cord-015021-pol2qm74	2212	13	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2212	14	levels	level	NNS
cord-015021-pol2qm74	2212	15	.	.	.
cord-015021-pol2qm74	2213	1	The	the	DT
cord-015021-pol2qm74	2213	2	mean	mean	JJ
cord-015021-pol2qm74	2213	3	plasma	plasma	NN
cord-015021-pol2qm74	2213	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2213	5	level	level	NN
cord-015021-pol2qm74	2213	6	of	of	IN
cord-015021-pol2qm74	2213	7	0	0	CD
cord-015021-pol2qm74	2213	8	,	,	,
cord-015021-pol2qm74	2213	9	2,4	2,4	CD
cord-015021-pol2qm74	2213	10	,	,	,
cord-015021-pol2qm74	2213	11	6	6	CD
cord-015021-pol2qm74	2213	12	,	,	,
cord-015021-pol2qm74	2213	13	8	8	CD
cord-015021-pol2qm74	2213	14	hours	hour	NNS
cord-015021-pol2qm74	2213	15	after	after	IN
cord-015021-pol2qm74	2213	16	the	the	DT
cord-015021-pol2qm74	2213	17	treatment	treatment	NN
cord-015021-pol2qm74	2213	18	were	be	VBD
cord-015021-pol2qm74	2213	19	6.48	6.48	CD
cord-015021-pol2qm74	2213	20	±	±	CD
cord-015021-pol2qm74	2213	21	5.57	5.57	CD
cord-015021-pol2qm74	2213	22	,	,	,
cord-015021-pol2qm74	2213	23	15.0	15.0	CD
cord-015021-pol2qm74	2213	24	_	_	NN
cord-015021-pol2qm74	2213	25	-4	-4	NNP
cord-015021-pol2qm74	2213	26	-	-	HYPH
cord-015021-pol2qm74	2213	27	4.37	4.37	CD
cord-015021-pol2qm74	2213	28	,	,	,
cord-015021-pol2qm74	2213	29	10.0	10.0	CD
cord-015021-pol2qm74	2213	30	_	_	NN
cord-015021-pol2qm74	2213	31	+	+	SYM
cord-015021-pol2qm74	2213	32	4.18	4.18	CD
cord-015021-pol2qm74	2213	33	,	,	,
cord-015021-pol2qm74	2213	34	14.4	14.4	CD
cord-015021-pol2qm74	2213	35	±	±	CD
cord-015021-pol2qm74	2213	36	3.52	3.52	CD
cord-015021-pol2qm74	2213	37	and	and	CC
cord-015021-pol2qm74	2213	38	58.4	58.4	CD
cord-015021-pol2qm74	2213	39	±	±	CD
cord-015021-pol2qm74	2213	40	28	28	CD
cord-015021-pol2qm74	2213	41	.6	.6	CD
cord-015021-pol2qm74	2213	42	pg	pg	NNP
cord-015021-pol2qm74	2213	43	/	/	SYM
cord-015021-pol2qm74	2213	44	ml	ml	NNS
cord-015021-pol2qm74	2213	45	,	,	,
cord-015021-pol2qm74	2213	46	respectively	respectively	RB
cord-015021-pol2qm74	2213	47	.	.	.
cord-015021-pol2qm74	2214	1	The	the	DT
cord-015021-pol2qm74	2214	2	results	result	NNS
cord-015021-pol2qm74	2214	3	indicate	indicate	VBP
cord-015021-pol2qm74	2214	4	that	that	IN
cord-015021-pol2qm74	2214	5	limbic	limbic	JJ
cord-015021-pol2qm74	2214	6	and	and	CC
cord-015021-pol2qm74	2214	7	hypothalamic	hypothalamic	JJ
cord-015021-pol2qm74	2214	8	-	-	HYPH
cord-015021-pol2qm74	2214	9	brainstem	brainstem	NN
cord-015021-pol2qm74	2214	10	systems	system	NNS
cord-015021-pol2qm74	2214	11	are	be	VBP
cord-015021-pol2qm74	2214	12	involved	involve	VBN
cord-015021-pol2qm74	2214	13	in	in	IN
cord-015021-pol2qm74	2214	14	SMA	SMA	NNP
cord-015021-pol2qm74	2214	15	occlusion	occlusion	NN
cord-015021-pol2qm74	2214	16	,	,	,
cord-015021-pol2qm74	2214	17	and	and	CC
cord-015021-pol2qm74	2214	18	suggest	suggest	VBP
cord-015021-pol2qm74	2214	19	that	that	IN
cord-015021-pol2qm74	2214	20	such	such	JJ
cord-015021-pol2qm74	2214	21	neuronal	neuronal	JJ
cord-015021-pol2qm74	2214	22	actival.jon	actival.jon	NNP
cord-015021-pol2qm74	2214	23	may	may	MD
cord-015021-pol2qm74	2214	24	precede	precede	VB
cord-015021-pol2qm74	2214	25	the	the	DT
cord-015021-pol2qm74	2214	26	elevation	elevation	NN
cord-015021-pol2qm74	2214	27	of	of	IN
cord-015021-pol2qm74	2214	28	plasma	plasma	NN
cord-015021-pol2qm74	2214	29	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2214	30	Icy.el	icy.el	NN
cord-015021-pol2qm74	2214	31	.	.	.
cord-015021-pol2qm74	2215	1	systemic	systemic	JJ
cord-015021-pol2qm74	2215	2	vascular	vascular	JJ
cord-015021-pol2qm74	2215	3	resistance	resistance	NN
cord-015021-pol2qm74	2215	4	and	and	CC
cord-015021-pol2qm74	2215	5	increased	increase	VBN
cord-015021-pol2qm74	2215	6	cardiac	cardiac	JJ
cord-015021-pol2qm74	2215	7	output	output	NN
cord-015021-pol2qm74	2215	8	accompanied	accompany	VBN
cord-015021-pol2qm74	2215	9	presumingly	presumingly	RB
cord-015021-pol2qm74	2215	10	by	by	IN
cord-015021-pol2qm74	2215	11	a	a	DT
cord-015021-pol2qm74	2215	12	increased	increase	VBN
cord-015021-pol2qm74	2215	13	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2215	14	shunt	shunt	NN
cord-015021-pol2qm74	2215	15	(	(	-LRB-
cord-015021-pol2qm74	2215	16	Qs	Qs	NNP
cord-015021-pol2qm74	2215	17	/	/	SYM
cord-015021-pol2qm74	2215	18	Qt	qt	NN
cord-015021-pol2qm74	2215	19	)	)	-RRB-
cord-015021-pol2qm74	2215	20	.	.	.
cord-015021-pol2qm74	2216	1	This	this	DT
cord-015021-pol2qm74	2216	2	response	response	NN
cord-015021-pol2qm74	2216	3	is	be	VBZ
cord-015021-pol2qm74	2216	4	induced	induce	VBN
cord-015021-pol2qm74	2216	5	by	by	IN
cord-015021-pol2qm74	2216	6	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	2216	7	(	(	-LRB-
cord-015021-pol2qm74	2216	8	PGI2	PGI2	NNP
cord-015021-pol2qm74	2216	9	)	)	-RRB-
cord-015021-pol2qm74	2216	10	.	.	.
cord-015021-pol2qm74	2217	1	We	-PRON-	PRP
cord-015021-pol2qm74	2217	2	examined	examine	VBD
cord-015021-pol2qm74	2217	3	oxygen	oxygen	NN
cord-015021-pol2qm74	2217	4	transport	transport	NN
cord-015021-pol2qm74	2217	5	after	after	IN
cord-015021-pol2qm74	2217	6	traction	traction	NN
cord-015021-pol2qm74	2217	7	on	on	IN
cord-015021-pol2qm74	2217	8	the	the	DT
cord-015021-pol2qm74	2217	9	mesentery	mesentery	NN
cord-015021-pol2qm74	2217	10	root	root	NN
cord-015021-pol2qm74	2217	11	and	and	CC
cord-015021-pol2qm74	2217	12	the	the	DT
cord-015021-pol2qm74	2217	13	transpulmonary	transpulmonary	JJ
cord-015021-pol2qm74	2217	14	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	2217	15	levels	level	NNS
cord-015021-pol2qm74	2217	16	in	in	IN
cord-015021-pol2qm74	2217	17	a	a	DT
cord-015021-pol2qm74	2217	18	prospective	prospective	JJ
cord-015021-pol2qm74	2217	19	placebo	placebo	NN
cord-015021-pol2qm74	2217	20	controlled	control	VBN
cord-015021-pol2qm74	2217	21	study	study	NN
cord-015021-pol2qm74	2217	22	with	with	IN
cord-015021-pol2qm74	2217	23	intravenous	intravenous	JJ
cord-015021-pol2qm74	2217	24	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	2217	25	.	.	.
cord-015021-pol2qm74	2218	1	METHODS	methods	NN
cord-015021-pol2qm74	2218	2	:	:	:
cord-015021-pol2qm74	2219	1	With	with	IN
cord-015021-pol2qm74	2219	2	approval	approval	NN
cord-015021-pol2qm74	2219	3	of	of	IN
cord-015021-pol2qm74	2219	4	the	the	DT
cord-015021-pol2qm74	2219	5	Human	human	JJ
cord-015021-pol2qm74	2219	6	[	[	-LRB-
cord-015021-pol2qm74	2219	7	nvestigadon	nvestigadon	NNP
cord-015021-pol2qm74	2219	8	Review	Review	NNP
cord-015021-pol2qm74	2219	9	Board	Board	NNP
cord-015021-pol2qm74	2219	10	we	-PRON-	PRP
cord-015021-pol2qm74	2219	11	studied	study	VBD
cord-015021-pol2qm74	2219	12	52	52	CD
cord-015021-pol2qm74	2219	13	patients	patient	NNS
cord-015021-pol2qm74	2219	14	in	in	IN
cord-015021-pol2qm74	2219	15	a	a	DT
cord-015021-pol2qm74	2219	16	prospective	prospective	NN
cord-015021-pol2qm74	2219	17	,	,	,
cord-015021-pol2qm74	2219	18	randomized	randomized	JJ
cord-015021-pol2qm74	2219	19	double	double	JJ
cord-015021-pol2qm74	2219	20	-	-	HYPH
cord-015021-pol2qm74	2219	21	blinded	blinded	JJ
cord-015021-pol2qm74	2219	22	protocol	protocol	NN
cord-015021-pol2qm74	2219	23	who	who	WP
cord-015021-pol2qm74	2219	24	were	be	VBD
cord-015021-pol2qm74	2219	25	scheduled	schedule	VBN
cord-015021-pol2qm74	2219	26	for	for	IN
cord-015021-pol2qm74	2219	27	major	major	JJ
cord-015021-pol2qm74	2219	28	abdominal	abdominal	JJ
cord-015021-pol2qm74	2219	29	surgery	surgery	NN
cord-015021-pol2qm74	2219	30	.	.	.
cord-015021-pol2qm74	2220	1	Ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	2220	2	(	(	-LRB-
cord-015021-pol2qm74	2220	3	400	400	CD
cord-015021-pol2qm74	2220	4	mg	mg	NNP
cord-015021-pol2qm74	2220	5	i.v	i.v	NNP
cord-015021-pol2qm74	2220	6	.	.	NNP
cord-015021-pol2qm74	2220	7	)	)	-RRB-
cord-015021-pol2qm74	2220	8	or	or	CC
cord-015021-pol2qm74	2220	9	a	a	DT
cord-015021-pol2qm74	2220	10	placebo	placebo	NN
cord-015021-pol2qm74	2220	11	equivalent	equivalent	NN
cord-015021-pol2qm74	2220	12	was	be	VBD
cord-015021-pol2qm74	2220	13	administered	administer	VBN
cord-015021-pol2qm74	2220	14	15	15	CD
cord-015021-pol2qm74	2220	15	minutes	minute	NNS
cord-015021-pol2qm74	2220	16	before	before	IN
cord-015021-pol2qm74	2220	17	skin	skin	NN
cord-015021-pol2qm74	2220	18	incision	incision	NN
cord-015021-pol2qm74	2220	19	.	.	.
cord-015021-pol2qm74	2221	1	Pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2221	2	artery	artery	NN
cord-015021-pol2qm74	2221	3	thermodilution	thermodilution	NN
cord-015021-pol2qm74	2221	4	and	and	CC
cord-015021-pol2qm74	2221	5	radial	radial	JJ
cord-015021-pol2qm74	2221	6	artery	artery	NN
cord-015021-pol2qm74	2221	7	catheters	catheter	NNS
cord-015021-pol2qm74	2221	8	were	be	VBD
cord-015021-pol2qm74	2221	9	placed	place	VBN
cord-015021-pol2qm74	2221	10	after	after	IN
cord-015021-pol2qm74	2221	11	induction	induction	NN
cord-015021-pol2qm74	2221	12	of	of	IN
cord-015021-pol2qm74	2221	13	anesthesia	anesthesia	NN
cord-015021-pol2qm74	2221	14	.	.	.
cord-015021-pol2qm74	2222	1	MT	MT	NNP
cord-015021-pol2qm74	2222	2	was	be	VBD
cord-015021-pol2qm74	2222	3	applied	apply	VBN
cord-015021-pol2qm74	2222	4	in	in	IN
cord-015021-pol2qm74	2222	5	a	a	DT
cord-015021-pol2qm74	2222	6	uniform	uniform	JJ
cord-015021-pol2qm74	2222	7	fashion	fashion	NN
cord-015021-pol2qm74	2222	8	.	.	.
cord-015021-pol2qm74	2223	1	Baseline	baseline	JJ
cord-015021-pol2qm74	2223	2	values	value	NNS
cord-015021-pol2qm74	2223	3	preceded	precede	VBD
cord-015021-pol2qm74	2223	4	the	the	DT
cord-015021-pol2qm74	2223	5	incision	incision	NN
cord-015021-pol2qm74	2223	6	of	of	IN
cord-015021-pol2qm74	2223	7	the	the	DT
cord-015021-pol2qm74	2223	8	peritoneum	peritoneum	NN
cord-015021-pol2qm74	2223	9	(	(	-LRB-
cord-015021-pol2qm74	2223	10	tO	to	IN
cord-015021-pol2qm74	2223	11	)	)	-RRB-
cord-015021-pol2qm74	2223	12	.	.	.
cord-015021-pol2qm74	2224	1	Fulther	Fulther	NNP
cord-015021-pol2qm74	2224	2	assessments	assessment	NNS
cord-015021-pol2qm74	2224	3	followed	follow	VBD
cord-015021-pol2qm74	2224	4	5	5	CD
cord-015021-pol2qm74	2224	5	,	,	,
cord-015021-pol2qm74	2224	6	15	15	CD
cord-015021-pol2qm74	2224	7	,	,	,
cord-015021-pol2qm74	2224	8	30	30	CD
cord-015021-pol2qm74	2224	9	,	,	,
cord-015021-pol2qm74	2224	10	45	45	CD
cord-015021-pol2qm74	2224	11	,	,	,
cord-015021-pol2qm74	2224	12	.	.	.
cord-015021-pol2qm74	2225	1	Tile	tile	NN
cord-015021-pol2qm74	2225	2	plasma	plasma	NN
cord-015021-pol2qm74	2225	3	concentrations	concentration	NNS
cord-015021-pol2qm74	2225	4	(	(	-LRB-
cord-015021-pol2qm74	2225	5	pc	pc	NNP
cord-015021-pol2qm74	2225	6	)	)	-RRB-
cord-015021-pol2qm74	2225	7	of	of	IN
cord-015021-pol2qm74	2225	8	6-keto	6-keto	CD
cord-015021-pol2qm74	2225	9	-	-	HYPH
cord-015021-pol2qm74	2225	10	PGFt	PGFt	NNS
cord-015021-pol2qm74	2225	11	,	,	,
cord-015021-pol2qm74	2225	12	(	(	-LRB-
cord-015021-pol2qm74	2225	13	stable	stable	JJ
cord-015021-pol2qm74	2225	14	metabolite	metabolite	NN
cord-015021-pol2qm74	2225	15	of	of	IN
cord-015021-pol2qm74	2225	16	PGI2	PGI2	NNP
cord-015021-pol2qm74	2225	17	)	)	-RRB-
cord-015021-pol2qm74	2225	18	were	be	VBD
cord-015021-pol2qm74	2225	19	determined	determine	VBN
cord-015021-pol2qm74	2225	20	in	in	IN
cord-015021-pol2qm74	2225	21	arterial	arterial	JJ
cord-015021-pol2qm74	2225	22	and	and	CC
cord-015021-pol2qm74	2225	23	mixed	mixed	JJ
cord-015021-pol2qm74	2225	24	venous	venous	JJ
cord-015021-pol2qm74	2225	25	blood	blood	NN
cord-015021-pol2qm74	2225	26	by	by	IN
cord-015021-pol2qm74	2225	27	radioimmunoassay	radioimmunoassay	NN
cord-015021-pol2qm74	2225	28	.	.	.
cord-015021-pol2qm74	2226	1	At	at	IN
cord-015021-pol2qm74	2226	2	all	all	DT
cord-015021-pol2qm74	2226	3	points	point	NNS
cord-015021-pol2qm74	2226	4	in	in	IN
cord-015021-pol2qm74	2226	5	time	time	NN
cord-015021-pol2qm74	2226	6	we	-PRON-	PRP
cord-015021-pol2qm74	2226	7	measured	measure	VBD
cord-015021-pol2qm74	2226	8	arterial	arterial	JJ
cord-015021-pol2qm74	2226	9	and	and	CC
cord-015021-pol2qm74	2226	10	mixed	mixed	JJ
cord-015021-pol2qm74	2226	11	venous	venous	JJ
cord-015021-pol2qm74	2226	12	blood	blood	NN
cord-015021-pol2qm74	2226	13	gases	gas	NNS
cord-015021-pol2qm74	2226	14	.	.	.
cord-015021-pol2qm74	2227	1	Qs	Qs	NNP
cord-015021-pol2qm74	2227	2	/	/	SYM
cord-015021-pol2qm74	2227	3	Qt	Qt	NNP
cord-015021-pol2qm74	2227	4	was	be	VBD
cord-015021-pol2qm74	2227	5	calculated	calculate	VBN
cord-015021-pol2qm74	2227	6	by	by	IN
cord-015021-pol2qm74	2227	7	standard	standard	JJ
cord-015021-pol2qm74	2227	8	formula	formula	NN
cord-015021-pol2qm74	2227	9	.	.	.
cord-015021-pol2qm74	2228	1	Data	datum	NNS
cord-015021-pol2qm74	2228	2	are	be	VBP
cord-015021-pol2qm74	2228	3	given	give	VBN
cord-015021-pol2qm74	2228	4	as	as	IN
cord-015021-pol2qm74	2228	5	median	median	NN
cord-015021-pol2qm74	2228	6	(	(	-LRB-
cord-015021-pol2qm74	2228	7	p	p	NN
cord-015021-pol2qm74	2228	8	<	<	XX
cord-015021-pol2qm74	2228	9	0.05	0.05	CD
cord-015021-pol2qm74	2228	10	placebo	placebo	NN
cord-015021-pol2qm74	2228	11	vs.	vs.	IN
cord-015021-pol2qm74	2228	12	[	[	-LRB-
cord-015021-pol2qm74	2228	13	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	2228	14	]	]	-RRB-
cord-015021-pol2qm74	2228	15	[	[	-LRB-
cord-015021-pol2qm74	2228	16	117	117	CD
cord-015021-pol2qm74	2228	17	]	]	-RRB-
cord-015021-pol2qm74	2228	18	mmHg	mmHg	NNPS
cord-015021-pol2qm74	2228	19	(	(	-LRB-
cord-015021-pol2qm74	2228	20	*	*	NFP
cord-015021-pol2qm74	2228	21	p	p	XX
cord-015021-pol2qm74	2228	22	<	<	XX
cord-015021-pol2qm74	2228	23	0.0i	0.0i	CD
cord-015021-pol2qm74	2228	24	)	)	-RRB-
cord-015021-pol2qm74	2228	25	.	.	.
cord-015021-pol2qm74	2229	1	These	these	DT
cord-015021-pol2qm74	2229	2	changes	change	NNS
cord-015021-pol2qm74	2229	3	were	be	VBD
cord-015021-pol2qm74	2229	4	accompanied	accompany	VBN
cord-015021-pol2qm74	2229	5	by	by	IN
cord-015021-pol2qm74	2229	6	a	a	DT
cord-015021-pol2qm74	2229	7	marked	marked	JJ
cord-015021-pol2qm74	2229	8	increase	increase	NN
cord-015021-pol2qm74	2229	9	of	of	IN
cord-015021-pol2qm74	2230	1	6-keto	6-keto	CD
cord-015021-pol2qm74	2230	2	-	-	SYM
cord-015021-pol2qm74	2230	3	PGF~	pgf~	NN
cord-015021-pol2qm74	2230	4	pc	pc	VBP
cord-015021-pol2qm74	2230	5	up	up	IN
cord-015021-pol2qm74	2230	6	to	to	TO
cord-015021-pol2qm74	2230	7	180	180	CD
cord-015021-pol2qm74	2230	8	rain	rain	NN
cord-015021-pol2qm74	2230	9	after	after	IN
cord-015021-pol2qm74	2230	10	MT	MT	NNP
cord-015021-pol2qm74	2230	11	in	in	IN
cord-015021-pol2qm74	2230	12	arterial	arterial	JJ
cord-015021-pol2qm74	2230	13	and	and	CC
cord-015021-pol2qm74	2230	14	mixed	mixed	JJ
cord-015021-pol2qm74	2230	15	venous	venous	JJ
cord-015021-pol2qm74	2230	16	blood	blood	NN
cord-015021-pol2qm74	2230	17	of	of	IN
cord-015021-pol2qm74	2230	18	untreated	untreated	JJ
cord-015021-pol2qm74	2230	19	patients	patient	NNS
cord-015021-pol2qm74	2230	20	with	with	IN
cord-015021-pol2qm74	2230	21	a	a	DT
cord-015021-pol2qm74	2230	22	peak	peak	NN
cord-015021-pol2qm74	2230	23	of	of	IN
cord-015021-pol2qm74	2230	24	2450*[60	2450*[60	CD
cord-015021-pol2qm74	2230	25	]	]	-RRB-
cord-015021-pol2qm74	2231	1	ng	ng	NNP
cord-015021-pol2qm74	2231	2	/	/	SYM
cord-015021-pol2qm74	2231	3	l	l	NNP
cord-015021-pol2qm74	2231	4	tl	tl	NNP
cord-015021-pol2qm74	2232	1	(	(	-LRB-
cord-015021-pol2qm74	2232	2	*	*	NFP
cord-015021-pol2qm74	2232	3	p	p	XX
cord-015021-pol2qm74	2232	4	<	<	XX
cord-015021-pol2qm74	2232	5	0.00Ol	0.00Ol	NFP
cord-015021-pol2qm74	2232	6	)	)	-RRB-
cord-015021-pol2qm74	2232	7	.	.	.
cord-015021-pol2qm74	2233	1	There	there	EX
cord-015021-pol2qm74	2233	2	was	be	VBD
cord-015021-pol2qm74	2233	3	no	no	DT
cord-015021-pol2qm74	2233	4	difference	difference	NN
cord-015021-pol2qm74	2233	5	between	between	IN
cord-015021-pol2qm74	2233	6	arterial	arterial	NN
cord-015021-pol2qm74	2233	7	and	and	CC
cord-015021-pol2qm74	2233	8	mixed	mixed	JJ
cord-015021-pol2qm74	2233	9	venous	venous	JJ
cord-015021-pol2qm74	2233	10	pc	pc	NN
cord-015021-pol2qm74	2233	11	.	.	.
cord-015021-pol2qm74	2234	1	Ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	2234	2	pretreated	pretreate	VBD
cord-015021-pol2qm74	2234	3	patients	patient	NNS
cord-015021-pol2qm74	2234	4	(	(	-LRB-
cord-015021-pol2qm74	2234	5	n	n	NN
cord-015021-pol2qm74	2234	6	=	=	SYM
cord-015021-pol2qm74	2234	7	zr	zr	NNP
cord-015021-pol2qm74	2234	8	)	)	-RRB-
cord-015021-pol2qm74	2234	9	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	2234	10	stabile	stabile	JJ
cord-015021-pol2qm74	2234	11	Qs	Qs	NNP
cord-015021-pol2qm74	2234	12	/	/	SYM
cord-015021-pol2qm74	2234	13	Qt	qt	NN
cord-015021-pol2qm74	2234	14	and	and	CC
cord-015021-pol2qm74	2234	15	paO2	pao2	NN
cord-015021-pol2qm74	2234	16	while	while	IN
cord-015021-pol2qm74	2234	17	6-keto	6-keto	CD
cord-015021-pol2qm74	2234	18	-	-	HYPH
cord-015021-pol2qm74	2234	19	PGF~	PGF~	NNP
cord-015021-pol2qm74	2234	20	pc	pc	NN
cord-015021-pol2qm74	2234	21	remained	remain	VBD
cord-015021-pol2qm74	2234	22	within	within	IN
cord-015021-pol2qm74	2234	23	the	the	DT
cord-015021-pol2qm74	2234	24	normal	normal	JJ
cord-015021-pol2qm74	2234	25	range	range	NN
cord-015021-pol2qm74	2234	26	.	.	.
cord-015021-pol2qm74	2235	1	DISCUSSION	discussion	NN
cord-015021-pol2qm74	2235	2	:	:	:
cord-015021-pol2qm74	2236	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2236	2	data	datum	NNS
cord-015021-pol2qm74	2236	3	clearly	clearly	RB
cord-015021-pol2qm74	2236	4	indicate	indicate	VBP
cord-015021-pol2qm74	2236	5	that	that	IN
cord-015021-pol2qm74	2236	6	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	2236	7	traction	traction	NN
cord-015021-pol2qm74	2236	8	response	response	NN
cord-015021-pol2qm74	2236	9	includes	include	VBZ
cord-015021-pol2qm74	2236	10	a	a	DT
cord-015021-pol2qm74	2236	11	critical	critical	JJ
cord-015021-pol2qm74	2236	12	rise	rise	NN
cord-015021-pol2qm74	2236	13	in	in	IN
cord-015021-pol2qm74	2236	14	Qs	Qs	NNP
cord-015021-pol2qm74	2236	15	/	/	SYM
cord-015021-pol2qm74	2236	16	Qt	Qt	NNP
cord-015021-pol2qm74	2236	17	followed	follow	VBN
cord-015021-pol2qm74	2236	18	by	by	IN
cord-015021-pol2qm74	2236	19	significant	significant	JJ
cord-015021-pol2qm74	2236	20	decrease	decrease	NN
cord-015021-pol2qm74	2236	21	of	of	IN
cord-015021-pol2qm74	2236	22	paOv	paov	NN
cord-015021-pol2qm74	2236	23	Stable	stable	JJ
cord-015021-pol2qm74	2236	24	oxygen	oxygen	NN
cord-015021-pol2qm74	2236	25	transport	transport	NN
cord-015021-pol2qm74	2236	26	determinants	determinant	NNS
cord-015021-pol2qm74	2236	27	following	follow	VBG
cord-015021-pol2qm74	2236	28	cyclooxygenase	cyclooxygenase	NN
cord-015021-pol2qm74	2236	29	inhibition	inhibition	NN
cord-015021-pol2qm74	2236	30	signify	signify	VBP
cord-015021-pol2qm74	2236	31	an	an	DT
cord-015021-pol2qm74	2236	32	action	action	NN
cord-015021-pol2qm74	2236	33	mediated	mediate	VBN
cord-015021-pol2qm74	2236	34	by	by	IN
cord-015021-pol2qm74	2236	35	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	2236	36	.	.	.
cord-015021-pol2qm74	2237	1	An	an	DT
cord-015021-pol2qm74	2237	2	indicative	indicative	JJ
cord-015021-pol2qm74	2237	3	transpulmonary	transpulmonary	JJ
cord-015021-pol2qm74	2237	4	gradient	gradient	NN
cord-015021-pol2qm74	2237	5	for	for	IN
cord-015021-pol2qm74	2238	1	6-keto	6-keto	NNP
cord-015021-pol2qm74	2238	2	-	-	:
cord-015021-pol2qm74	2238	3	PGFt~	PGFt~	NNP
cord-015021-pol2qm74	2238	4	was	be	VBD
cord-015021-pol2qm74	2238	5	not	not	RB
cord-015021-pol2qm74	2238	6	detectable	detectable	JJ
cord-015021-pol2qm74	2238	7	.	.	.
cord-015021-pol2qm74	2239	1	A	a	DT
cord-015021-pol2qm74	2239	2	splanchnic	splanchnic	JJ
cord-015021-pol2qm74	2239	3	vascular	vascular	JJ
cord-015021-pol2qm74	2239	4	source	source	NN
cord-015021-pol2qm74	2239	5	for	for	IN
cord-015021-pol2qm74	2239	6	PGI2	PGI2	NNP
cord-015021-pol2qm74	2239	7	release	release	NN
cord-015021-pol2qm74	2239	8	seems	seem	VBZ
cord-015021-pol2qm74	2239	9	to	to	TO
cord-015021-pol2qm74	2239	10	be	be	VB
cord-015021-pol2qm74	2239	11	likely	likely	JJ
cord-015021-pol2qm74	2239	12	,	,	,
cord-015021-pol2qm74	2239	13	but	but	CC
cord-015021-pol2qm74	2239	14	could	could	MD
cord-015021-pol2qm74	2239	15	not	not	RB
cord-015021-pol2qm74	2239	16	be	be	VB
cord-015021-pol2qm74	2239	17	proved	prove	VBN
cord-015021-pol2qm74	2239	18	by	by	IN
cord-015021-pol2qm74	2239	19	our	-PRON-	PRP$
cord-015021-pol2qm74	2239	20	current	current	JJ
cord-015021-pol2qm74	2239	21	data	datum	NNS
cord-015021-pol2qm74	2239	22	.	.	.
cord-015021-pol2qm74	2240	1	Department	Department	NNP
cord-015021-pol2qm74	2240	2	of	of	IN
cord-015021-pol2qm74	2240	3	Anesthesiology	Anesthesiology	NNP
cord-015021-pol2qm74	2240	4	,	,	,
cord-015021-pol2qm74	2240	5	Cliu	Cliu	NNP
cord-015021-pol2qm74	2240	6	.	.	.
cord-015021-pol2qm74	2241	1	Chemistry	chemistry	NN
cord-015021-pol2qm74	2241	2	*	*	NFP
cord-015021-pol2qm74	2241	3	and	and	CC
cord-015021-pol2qm74	2241	4	Surgery	surgery	NN
cord-015021-pol2qm74	2241	5	*	*	NFP
cord-015021-pol2qm74	2241	6	;	;	:
cord-015021-pol2qm74	2241	7	University	University	NNP
cord-015021-pol2qm74	2241	8	Clinics	Clinics	NNPS
cord-015021-pol2qm74	2241	9	UIm	UIm	NNS
cord-015021-pol2qm74	2241	10	,	,	,
cord-015021-pol2qm74	2241	11	Prittwitzstral]e	Prittwitzstral]e	NNP
cord-015021-pol2qm74	2241	12	43	43	CD
cord-015021-pol2qm74	2241	13	,	,	,
cord-015021-pol2qm74	2241	14	89075	89075	CD
cord-015021-pol2qm74	2241	15	Ulm	Ulm	NNP
cord-015021-pol2qm74	2241	16	,	,	,
cord-015021-pol2qm74	2241	17	Germany	Germany	NNP
cord-015021-pol2qm74	2242	1	It	-PRON-	PRP
cord-015021-pol2qm74	2242	2	is	be	VBZ
cord-015021-pol2qm74	2242	3	unclear	unclear	JJ
cord-015021-pol2qm74	2242	4	whether	whether	IN
cord-015021-pol2qm74	2242	5	injuries	injury	NNS
cord-015021-pol2qm74	2242	6	like	like	IN
cord-015021-pol2qm74	2242	7	bums	bum	NNS
cord-015021-pol2qm74	2242	8	,	,	,
cord-015021-pol2qm74	2242	9	in	in	IN
cord-015021-pol2qm74	2242	10	general	general	JJ
cord-015021-pol2qm74	2242	11	,	,	,
cord-015021-pol2qm74	2242	12	directly	directly	RB
cord-015021-pol2qm74	2242	13	result	result	VB
cord-015021-pol2qm74	2242	14	in	in	IN
cord-015021-pol2qm74	2242	15	alterations	alteration	NNS
cord-015021-pol2qm74	2242	16	of	of	IN
cord-015021-pol2qm74	2242	17	cell	cell	NN
cord-015021-pol2qm74	2242	18	-	-	HYPH
cord-015021-pol2qm74	2242	19	mediated	mediate	VBN
cord-015021-pol2qm74	2242	20	immunity	immunity	NN
cord-015021-pol2qm74	2242	21	that	that	WDT
cord-015021-pol2qm74	2242	22	,	,	,
cord-015021-pol2qm74	2242	23	in	in	IN
cord-015021-pol2qm74	2242	24	turn	turn	NN
cord-015021-pol2qm74	2242	25	,	,	,
cord-015021-pol2qm74	2242	26	promote	promote	VB
cord-015021-pol2qm74	2242	27	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	2242	28	and	and	CC
cord-015021-pol2qm74	2242	29	bacterial	bacterial	JJ
cord-015021-pol2qm74	2242	30	translocation	translocation	NN
cord-015021-pol2qm74	2242	31	or	or	CC
cord-015021-pol2qm74	2242	32	,	,	,
cord-015021-pol2qm74	2242	33	alternatively	alternatively	RB
cord-015021-pol2qm74	2242	34	,	,	,
cord-015021-pol2qm74	2242	35	whether	whether	IN
cord-015021-pol2qm74	2242	36	these	these	DT
cord-015021-pol2qm74	2242	37	conditions	condition	NNS
cord-015021-pol2qm74	2242	38	allow	allow	VBP
cord-015021-pol2qm74	2242	39	increased	increase	VBN
cord-015021-pol2qm74	2242	40	bacterial	bacterial	JJ
cord-015021-pol2qm74	2242	41	invasion	invasion	NN
cord-015021-pol2qm74	2242	42	that	that	WDT
cord-015021-pol2qm74	2242	43	,	,	,
cord-015021-pol2qm74	2242	44	in	in	IN
cord-015021-pol2qm74	2242	45	turn	turn	NN
cord-015021-pol2qm74	2242	46	,	,	,
cord-015021-pol2qm74	2242	47	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2242	48	CMI	CMI	NNP
cord-015021-pol2qm74	2242	49	.	.	.
cord-015021-pol2qm74	2243	1	Aim	aim	VB
cord-015021-pol2qm74	2243	2	:	:	:
cord-015021-pol2qm74	2243	3	To	to	TO
cord-015021-pol2qm74	2243	4	determine	determine	VB
cord-015021-pol2qm74	2243	5	whether	whether	IN
cord-015021-pol2qm74	2243	6	infectious	infectious	JJ
cord-015021-pol2qm74	2243	7	challenge	challenge	NN
cord-015021-pol2qm74	2243	8	,	,	,
cord-015021-pol2qm74	2243	9	as	as	IN
cord-015021-pol2qm74	2243	10	CLP	CLP	NNP
cord-015021-pol2qm74	2243	11	alone	alone	RB
cord-015021-pol2qm74	2243	12	or	or	CC
cord-015021-pol2qm74	2243	13	combined	combine	VBN
cord-015021-pol2qm74	2243	14	with	with	IN
cord-015021-pol2qm74	2243	15	TI	TI	NNP
cord-015021-pol2qm74	2243	16	causes	cause	VBZ
cord-015021-pol2qm74	2243	17	further	further	JJ
cord-015021-pol2qm74	2243	18	immune	immune	JJ
cord-015021-pol2qm74	2243	19	abnormalities	abnormality	NNS
cord-015021-pol2qm74	2243	20	in	in	IN
cord-015021-pol2qm74	2243	21	the	the	DT
cord-015021-pol2qm74	2243	22	days	day	NNS
cord-015021-pol2qm74	2243	23	following	follow	VBG
cord-015021-pol2qm74	2243	24	CLP	CLP	NNP
cord-015021-pol2qm74	2243	25	.	.	.
cord-015021-pol2qm74	2244	1	Study	study	NN
cord-015021-pol2qm74	2244	2	Plan	Plan	NNP
cord-015021-pol2qm74	2244	3	:	:	:
cord-015021-pol2qm74	2244	4	On	on	IN
cord-015021-pol2qm74	2244	5	day	day	NN
cord-015021-pol2qm74	2244	6	1	1	CD
cord-015021-pol2qm74	2244	7	,	,	,
cord-015021-pol2qm74	2244	8	two	two	CD
cord-015021-pol2qm74	2244	9	groups	group	NNS
cord-015021-pol2qm74	2244	10	of	of	IN
cord-015021-pol2qm74	2244	11	n=36	n=36	NNS
cord-015021-pol2qm74	2244	12	8	8	CD
cord-015021-pol2qm74	2244	13	week	week	NN
cord-015021-pol2qm74	2244	14	old	old	JJ
cord-015021-pol2qm74	2244	15	AJ	AJ	NNP
cord-015021-pol2qm74	2244	16	mice	mouse	NNS
cord-015021-pol2qm74	2244	17	were	be	VBD
cord-015021-pol2qm74	2244	18	subjected	subject	VBN
cord-015021-pol2qm74	2244	19	to	to	IN
cord-015021-pol2qm74	2244	20	either	either	CC
cord-015021-pol2qm74	2244	21	a	a	DT
cord-015021-pol2qm74	2244	22	20	20	CD
cord-015021-pol2qm74	2244	23	%	%	NN
cord-015021-pol2qm74	2244	24	scold	scold	NN
cord-015021-pol2qm74	2244	25	burn	burn	NN
cord-015021-pol2qm74	2244	26	(	(	-LRB-
cord-015021-pol2qm74	2244	27	TI	TI	NNP
cord-015021-pol2qm74	2244	28	)	)	-RRB-
cord-015021-pol2qm74	2244	29	,	,	,
cord-015021-pol2qm74	2244	30	or	or	CC
cord-015021-pol2qm74	2244	31	were	be	VBD
cord-015021-pol2qm74	2244	32	untreated	untreated	JJ
cord-015021-pol2qm74	2244	33	(	(	-LRB-
cord-015021-pol2qm74	2244	34	C	C	NNP
cord-015021-pol2qm74	2244	35	)	)	-RRB-
cord-015021-pol2qm74	2244	36	n=18	n=18	RB
cord-015021-pol2qm74	2244	37	.	.	.
cord-015021-pol2qm74	2245	1	On	on	IN
cord-015021-pol2qm74	2245	2	day	day	NN
cord-015021-pol2qm74	2245	3	10	10	CD
cord-015021-pol2qm74	2245	4	,	,	,
cord-015021-pol2qm74	2245	5	18	18	CD
cord-015021-pol2qm74	2245	6	mice	mouse	NNS
cord-015021-pol2qm74	2245	7	(	(	-LRB-
cord-015021-pol2qm74	2245	8	TI+CLP	TI+CLP	NNP
cord-015021-pol2qm74	2245	9	)	)	-RRB-
cord-015021-pol2qm74	2245	10	and	and	CC
cord-015021-pol2qm74	2245	11	24	24	CD
cord-015021-pol2qm74	2245	12	mice	mouse	NNS
cord-015021-pol2qm74	2245	13	(	(	-LRB-
cord-015021-pol2qm74	2245	14	CLP	CLP	NNP
cord-015021-pol2qm74	2245	15	)	)	-RRB-
cord-015021-pol2qm74	2245	16	were	be	VBD
cord-015021-pol2qm74	2245	17	subjected	subject	VBN
cord-015021-pol2qm74	2245	18	to	to	IN
cord-015021-pol2qm74	2245	19	CLP	CLP	NNP
cord-015021-pol2qm74	2245	20	.	.	.
cord-015021-pol2qm74	2246	1	The	the	DT
cord-015021-pol2qm74	2246	2	two	two	CD
cord-015021-pol2qm74	2246	3	other	other	JJ
cord-015021-pol2qm74	2246	4	groups	group	NNS
cord-015021-pol2qm74	2246	5	(	(	-LRB-
cord-015021-pol2qm74	2246	6	TI	TI	NNP
cord-015021-pol2qm74	2246	7	and	and	CC
cord-015021-pol2qm74	2246	8	C	C	NNP
cord-015021-pol2qm74	2246	9	)	)	-RRB-
cord-015021-pol2qm74	2246	10	were	be	VBD
cord-015021-pol2qm74	2246	11	untreated	untreated	JJ
cord-015021-pol2qm74	2246	12	.	.	.
cord-015021-pol2qm74	2247	1	At	at	IN
cord-015021-pol2qm74	2247	2	days	day	NNS
cord-015021-pol2qm74	2247	3	11	11	CD
cord-015021-pol2qm74	2247	4	,	,	,
cord-015021-pol2qm74	2247	5	12	12	CD
cord-015021-pol2qm74	2247	6	and	and	CC
cord-015021-pol2qm74	2247	7	13	13	CD
cord-015021-pol2qm74	2247	8	after	after	IN
cord-015021-pol2qm74	2247	9	thermal	thermal	JJ
cord-015021-pol2qm74	2247	10	injury	injury	NN
cord-015021-pol2qm74	2247	11	splenocytes	splenocytes	FW
cord-015021-pol2qm74	2247	12	(	(	-LRB-
cord-015021-pol2qm74	2247	13	SP	SP	NNP
cord-015021-pol2qm74	2247	14	)	)	-RRB-
cord-015021-pol2qm74	2247	15	were	be	VBD
cord-015021-pol2qm74	2247	16	harvested	harvest	VBN
cord-015021-pol2qm74	2247	17	and	and	CC
cord-015021-pol2qm74	2247	18	cultured	culture	VBN
cord-015021-pol2qm74	2247	19	with	with	IN
cord-015021-pol2qm74	2247	20	ConA	ConA	NNP
cord-015021-pol2qm74	2247	21	for	for	IN
cord-015021-pol2qm74	2247	22	an	an	DT
cord-015021-pol2qm74	2247	23	assay	assay	NN
cord-015021-pol2qm74	2247	24	of	of	IN
cord-015021-pol2qm74	2247	25	IL-2	il-2	NN
cord-015021-pol2qm74	2247	26	and	and	CC
cord-015021-pol2qm74	2247	27	adherent	adherent	JJ
cord-015021-pol2qm74	2247	28	splenocytes	splenocytes	NNP
cord-015021-pol2qm74	2247	29	(	(	-LRB-
cord-015021-pol2qm74	2247	30	AS	AS	NNP
cord-015021-pol2qm74	2247	31	)	)	-RRB-
cord-015021-pol2qm74	2247	32	were	be	VBD
cord-015021-pol2qm74	2247	33	cultured	culture	VBN
cord-015021-pol2qm74	2247	34	with	with	IN
cord-015021-pol2qm74	2247	35	LPS	LPS	NNP
cord-015021-pol2qm74	2247	36	for	for	IN
cord-015021-pol2qm74	2247	37	IL-1	IL-1	NNP
cord-015021-pol2qm74	2247	38	,	,	,
cord-015021-pol2qm74	2247	39	TNF	TNF	NNP
cord-015021-pol2qm74	2247	40	,	,	,
cord-015021-pol2qm74	2247	41	IL-6	IL-6	NNP
cord-015021-pol2qm74	2247	42	and	and	CC
cord-015021-pol2qm74	2247	43	PGE2	PGE2	NNP
cord-015021-pol2qm74	2247	44	.	.	.
cord-015021-pol2qm74	2248	1	Results	result	NNS
cord-015021-pol2qm74	2248	2	:	:	:
cord-015021-pol2qm74	2249	1	Either	either	CC
cord-015021-pol2qm74	2249	2	TI	TI	NNP
cord-015021-pol2qm74	2249	3	+	+	CC
cord-015021-pol2qm74	2249	4	CLP	clp	NN
cord-015021-pol2qm74	2249	5	or	or	CC
cord-015021-pol2qm74	2249	6	CLP	CLP	NNP
cord-015021-pol2qm74	2249	7	alone	alone	RB
cord-015021-pol2qm74	2249	8	result	result	VBP
cord-015021-pol2qm74	2249	9	in	in	IN
cord-015021-pol2qm74	2249	10	significantly	significantly	RB
cord-015021-pol2qm74	2249	11	decreased	decrease	VBD
cord-015021-pol2qm74	2249	12	secretion	secretion	NN
cord-015021-pol2qm74	2249	13	of	of	IN
cord-015021-pol2qm74	2249	14	all	all	DT
cord-015021-pol2qm74	2249	15	cytokines	cytokine	NNS
cord-015021-pol2qm74	2249	16	tested	test	VBN
cord-015021-pol2qm74	2249	17	.	.	.
cord-015021-pol2qm74	2250	1	In	in	IN
cord-015021-pol2qm74	2250	2	the	the	DT
cord-015021-pol2qm74	2250	3	TI	TI	NNP
cord-015021-pol2qm74	2250	4	group	group	NN
cord-015021-pol2qm74	2250	5	almost	almost	RB
cord-015021-pol2qm74	2250	6	every	every	DT
cord-015021-pol2qm74	2250	7	cytokine	cytokine	NN
cord-015021-pol2qm74	2250	8	production	production	NN
cord-015021-pol2qm74	2250	9	determined	determine	VBN
cord-015021-pol2qm74	2250	10	was	be	VBD
cord-015021-pol2qm74	2250	11	elevated	elevate	VBN
cord-015021-pol2qm74	2250	12	in	in	IN
cord-015021-pol2qm74	2250	13	comparison	comparison	NN
cord-015021-pol2qm74	2250	14	to	to	IN
cord-015021-pol2qm74	2250	15	TI	TI	NNP
cord-015021-pol2qm74	2250	16	+	+	CC
cord-015021-pol2qm74	2250	17	CLP	clp	NN
cord-015021-pol2qm74	2250	18	and	and	CC
cord-015021-pol2qm74	2250	19	Prosmcyclin	Prosmcyclin	NNP
cord-015021-pol2qm74	2250	20	(	(	-LRB-
cord-015021-pol2qm74	2250	21	PGI2	PGI2	NNP
cord-015021-pol2qm74	2250	22	)	)	-RRB-
cord-015021-pol2qm74	2250	23	has	have	VBZ
cord-015021-pol2qm74	2250	24	been	be	VBN
cord-015021-pol2qm74	2250	25	implicated	implicate	VBN
cord-015021-pol2qm74	2250	26	in	in	IN
cord-015021-pol2qm74	2250	27	the	the	DT
cord-015021-pol2qm74	2250	28	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	2250	29	of	of	IN
cord-015021-pol2qm74	2250	30	septic	septic	JJ
cord-015021-pol2qm74	2250	31	shock	shock	NN
cord-015021-pol2qm74	2250	32	.	.	.
cord-015021-pol2qm74	2251	1	However	however	RB
cord-015021-pol2qm74	2251	2	,	,	,
cord-015021-pol2qm74	2251	3	PGI~	PGI~	NNP
cord-015021-pol2qm74	2251	4	's	's	POS
cord-015021-pol2qm74	2251	5	role	role	NN
cord-015021-pol2qm74	2251	6	in	in	IN
cord-015021-pol2qm74	2251	7	the	the	DT
cord-015021-pol2qm74	2251	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2251	9	response	response	NN
cord-015021-pol2qm74	2251	10	to	to	IN
cord-015021-pol2qm74	2251	11	sepsis	sepsis	NN
cord-015021-pol2qm74	2251	12	is	be	VBZ
cord-015021-pol2qm74	2251	13	not	not	RB
cord-015021-pol2qm74	2251	14	well	well	RB
cord-015021-pol2qm74	2251	15	-	-	HYPH
cord-015021-pol2qm74	2251	16	defined	define	VBN
cord-015021-pol2qm74	2251	17	.	.	.
cord-015021-pol2qm74	2252	1	The	the	DT
cord-015021-pol2qm74	2252	2	purpose	purpose	NN
cord-015021-pol2qm74	2252	3	of	of	IN
cord-015021-pol2qm74	2252	4	this	this	DT
cord-015021-pol2qm74	2252	5	study	study	NN
cord-015021-pol2qm74	2252	6	was	be	VBD
cord-015021-pol2qm74	2252	7	to	to	TO
cord-015021-pol2qm74	2252	8	identify	identify	VB
cord-015021-pol2qm74	2252	9	which	which	WDT
cord-015021-pol2qm74	2252	10	acute	acute	JJ
cord-015021-pol2qm74	2252	11	septic	septic	JJ
cord-015021-pol2qm74	2252	12	events	event	NNS
cord-015021-pol2qm74	2252	13	are	be	VBP
cord-015021-pol2qm74	2252	14	mediated	mediate	VBN
cord-015021-pol2qm74	2252	15	by	by	IN
cord-015021-pol2qm74	2252	16	PGI	PGI	NNP
cord-015021-pol2qm74	2252	17	2	2	CD
cord-015021-pol2qm74	2252	18	during	during	IN
cord-015021-pol2qm74	2252	19	graded	grade	VBN
cord-015021-pol2qm74	2252	20	bacteremia	bacteremia	NN
cord-015021-pol2qm74	2252	21	.	.	.
cord-015021-pol2qm74	2253	1	METHODS	methods	NN
cord-015021-pol2qm74	2253	2	:	:	:
cord-015021-pol2qm74	2254	1	Eleven	Eleven	NNP
cord-015021-pol2qm74	2254	2	~nesrhetized	~nesrhetized	XX
cord-015021-pol2qm74	2254	3	,	,	,
cord-015021-pol2qm74	2254	4	hemodynamically	hemodynamically	RB
cord-015021-pol2qm74	2254	5	monitored	monitor	VBD
cord-015021-pol2qm74	2254	6	adult	adult	NN
cord-015021-pol2qm74	2254	7	swine	swine	NN
cord-015021-pol2qm74	2254	8	were	be	VBD
cord-015021-pol2qm74	2254	9	infused	infuse	VBN
cord-015021-pol2qm74	2254	10	IV	IV	NNP
cord-015021-pol2qm74	2254	11	with	with	IN
cord-015021-pol2qm74	2254	12	Aeromonas	Aeromonas	NNP
cord-015021-pol2qm74	2254	13	h.	h.	NNP
cord-015021-pol2qm74	2254	14	(	(	-LRB-
cord-015021-pol2qm74	2254	15	109	109	CD
cord-015021-pol2qm74	2254	16	/	/	SYM
cord-015021-pol2qm74	2254	17	ml	ml	NN
cord-015021-pol2qm74	2254	18	)	)	-RRB-
cord-015021-pol2qm74	2254	19	at	at	IN
cord-015021-pol2qm74	2254	20	rates	rate	NNS
cord-015021-pol2qm74	2254	21	increased	increase	VBD
cord-015021-pol2qm74	2254	22	incrementally	incrementally	RB
cord-015021-pol2qm74	2254	23	from	from	IN
cord-015021-pol2qm74	2254	24	0.2	0.2	CD
cord-015021-pol2qm74	2254	25	to	to	IN
cord-015021-pol2qm74	2254	26	4.0	4.0	CD
cord-015021-pol2qm74	2254	27	mI	mI	NNS
cord-015021-pol2qm74	2254	28	/	/	SYM
cord-015021-pol2qm74	2254	29	kg	kg	NN
cord-015021-pol2qm74	2254	30	/	/	SYM
cord-015021-pol2qm74	2254	31	hr	hr	NN
cord-015021-pol2qm74	2254	32	over	over	IN
cord-015021-pol2qm74	2254	33	4	4	CD
cord-015021-pol2qm74	2254	34	hours	hour	NNS
cord-015021-pol2qm74	2254	35	.	.	.
cord-015021-pol2qm74	2255	1	Animals	animal	NNS
cord-015021-pol2qm74	2255	2	were	be	VBD
cord-015021-pol2qm74	2255	3	studied	study	VBN
cord-015021-pol2qm74	2255	4	in	in	IN
cord-015021-pol2qm74	2255	5	two	two	CD
cord-015021-pol2qm74	2255	6	groups	group	NNS
cord-015021-pol2qm74	2255	7	:	:	:
cord-015021-pol2qm74	2255	8	septic	septic	JJ
cord-015021-pol2qm74	2255	9	control	control	NN
cord-015021-pol2qm74	2255	10	(	(	-LRB-
cord-015021-pol2qm74	2255	11	SC	SC	NNP
cord-015021-pol2qm74	2255	12	)	)	-RRB-
cord-015021-pol2qm74	2255	13	,	,	,
cord-015021-pol2qm74	2255	14	graded	grade	VBN
cord-015021-pol2qm74	2255	15	bacteremia	bacteremia	NN
cord-015021-pol2qm74	2255	16	only	only	RB
cord-015021-pol2qm74	2255	17	(	(	-LRB-
cord-015021-pol2qm74	2255	18	n=6	n=6	NNP
cord-015021-pol2qm74	2255	19	)	)	-RRB-
cord-015021-pol2qm74	2255	20	;	;	:
cord-015021-pol2qm74	2255	21	PGA	PGA	NNP
cord-015021-pol2qm74	2255	22	(	(	-LRB-
cord-015021-pol2qm74	2255	23	n=5	n=5	NNP
cord-015021-pol2qm74	2255	24	)	)	-RRB-
cord-015021-pol2qm74	2255	25	,	,	,
cord-015021-pol2qm74	2255	26	graded	grade	VBN
cord-015021-pol2qm74	2255	27	bacteremta	bacteremta	NNP
cord-015021-pol2qm74	2255	28	plus	plus	CC
cord-015021-pol2qm74	2255	29	anti	anti	JJ
cord-015021-pol2qm74	2255	30	-	-	JJ
cord-015021-pol2qm74	2255	31	PGIz	pgiz	JJ
cord-015021-pol2qm74	2255	32	antibody	antibody	NN
cord-015021-pol2qm74	2255	33	,	,	,
cord-015021-pol2qm74	2255	34	50	50	CD
cord-015021-pol2qm74	2255	35	ml	ml	NNS
cord-015021-pol2qm74	2255	36	/	/	SYM
cord-015021-pol2qm74	2255	37	hr	hr	NN
cord-015021-pol2qm74	2255	38	IV	IV	NNP
cord-015021-pol2qm74	2255	39	,	,	,
cord-015021-pol2qm74	2255	40	beginning	begin	VBG
cord-015021-pol2qm74	2255	41	at	at	IN
cord-015021-pol2qm74	2255	42	2	2	CD
cord-015021-pol2qm74	2255	43	hours	hour	NNS
cord-015021-pol2qm74	2255	44	.	.	.
cord-015021-pol2qm74	2256	1	Mean	mean	JJ
cord-015021-pol2qm74	2256	2	systemic	systemic	JJ
cord-015021-pol2qm74	2256	3	(	(	-LRB-
cord-015021-pol2qm74	2256	4	MAP	map	NN
cord-015021-pol2qm74	2256	5	)	)	-RRB-
cord-015021-pol2qm74	2256	6	and	and	CC
cord-015021-pol2qm74	2256	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2256	8	arterial	arterial	NN
cord-015021-pol2qm74	2256	9	(	(	-LRB-
cord-015021-pol2qm74	2256	10	PAP	pap	NN
cord-015021-pol2qm74	2256	11	)	)	-RRB-
cord-015021-pol2qm74	2256	12	pressures	pressure	NNS
cord-015021-pol2qm74	2256	13	and	and	CC
cord-015021-pol2qm74	2256	14	arterial	arterial	JJ
cord-015021-pol2qm74	2256	15	pO2	po2	NN
cord-015021-pol2qm74	2256	16	,	,	,
cord-015021-pol2qm74	2256	17	mmHg	mmHg	NNP
cord-015021-pol2qm74	2256	18	,	,	,
cord-015021-pol2qm74	2256	19	cardiac	cardiac	JJ
cord-015021-pol2qm74	2256	20	index	index	NN
cord-015021-pol2qm74	2256	21	(	(	-LRB-
cord-015021-pol2qm74	2256	22	CI	CI	NNP
cord-015021-pol2qm74	2256	23	)	)	-RRB-
cord-015021-pol2qm74	2256	24	,	,	,
cord-015021-pol2qm74	2256	25	L	L	NNP
cord-015021-pol2qm74	2256	26	/	/	SYM
cord-015021-pol2qm74	2256	27	min	min	NNP
cord-015021-pol2qm74	2256	28	/	/	SYM
cord-015021-pol2qm74	2256	29	M2	M2	NNP
cord-015021-pol2qm74	2256	30	,	,	,
cord-015021-pol2qm74	2256	31	oxygen	oxygen	NN
cord-015021-pol2qm74	2256	32	delivery	delivery	NN
cord-015021-pol2qm74	2256	33	index	index	NN
cord-015021-pol2qm74	2256	34	(	(	-LRB-
cord-015021-pol2qm74	2256	35	DO2I	do2i	NN
cord-015021-pol2qm74	2256	36	)	)	-RRB-
cord-015021-pol2qm74	2256	37	and	and	CC
cord-015021-pol2qm74	2256	38	consumption	consumption	NN
cord-015021-pol2qm74	2256	39	index	index	NN
cord-015021-pol2qm74	2256	40	(	(	-LRB-
cord-015021-pol2qm74	2256	41	VOzI	VOzI	NNP
cord-015021-pol2qm74	2256	42	)	)	-RRB-
cord-015021-pol2qm74	2256	43	,	,	,
cord-015021-pol2qm74	2256	44	ml	ml	NN
cord-015021-pol2qm74	2256	45	/	/	SYM
cord-015021-pol2qm74	2256	46	min	min	NNP
cord-015021-pol2qm74	2256	47	/	/	SYM
cord-015021-pol2qm74	2256	48	M2	M2	NNP
cord-015021-pol2qm74	2256	49	,	,	,
cord-015021-pol2qm74	2256	50	and	and	CC
cord-015021-pol2qm74	2256	51	oxygen	oxygen	NN
cord-015021-pol2qm74	2256	52	extraction	extraction	NN
cord-015021-pol2qm74	2256	53	(	(	-LRB-
cord-015021-pol2qm74	2256	54	ER	ER	NNP
cord-015021-pol2qm74	2256	55	)	)	-RRB-
cord-015021-pol2qm74	2256	56	,	,	,
cord-015021-pol2qm74	2256	57	%	%	NN
cord-015021-pol2qm74	2256	58	,	,	,
cord-015021-pol2qm74	2256	59	)	)	-RRB-
cord-015021-pol2qm74	2256	60	latelet	latelet	NNP
cord-015021-pol2qm74	2256	61	aggregometry	aggregometry	NNP
cord-015021-pol2qm74	2256	62	(	(	-LRB-
cord-015021-pol2qm74	2256	63	PLT	PLT	NNP
cord-015021-pol2qm74	2256	64	)	)	-RRB-
cord-015021-pol2qm74	2256	65	,	,	,
cord-015021-pol2qm74	2256	66	%	%	NN
cord-015021-pol2qm74	2256	67	max	max	NN
cord-015021-pol2qm74	2256	68	.	.	.
cord-015021-pol2qm74	2257	1	,	,	,
cord-015021-pol2qm74	2257	2	plasma	plasma	NNP
cord-015021-pol2qm74	2257	3	PG6-keto	PG6-keto	NNP
cord-015021-pol2qm74	2257	4	F1	f1	NN
cord-015021-pol2qm74	2257	5	alpha	alpha	NN
cord-015021-pol2qm74	2257	6	;	;	.
cord-015021-pol2qm74	2257	7	In	in	IN
cord-015021-pol2qm74	2257	8	the	the	DT
cord-015021-pol2qm74	2257	9	first	first	JJ
cord-015021-pol2qm74	2257	10	instance~	instance~	NNP
cord-015021-pol2qm74	2257	11	peak	peak	NN
cord-015021-pol2qm74	2257	12	values	value	NNS
cord-015021-pol2qm74	2257	13	of	of	IN
cord-015021-pol2qm74	2257	14	LT	LT	NNP
cord-015021-pol2qm74	2257	15	~4	~4	CD
cord-015021-pol2qm74	2257	16	after	after	IN
cord-015021-pol2qm74	2257	17	i~	i~	CD
cord-015021-pol2qm74	2257	18	hrs	hrs	NN
cord-015021-pol2qm74	2257	19	post	post	NN
cord-015021-pol2qm74	2257	20	infarction	infarction	NN
cord-015021-pol2qm74	2257	21	were	be	VBD
cord-015021-pol2qm74	2257	22	6	6	CD
cord-015021-pol2qm74	2257	23	times	time	NNS
cord-015021-pol2qm74	2257	24	higher	high	JJR
cord-015021-pol2qm74	2257	25	than	than	IN
cord-015021-pol2qm74	2257	26	in	in	IN
cord-015021-pol2qm74	2257	27	the	the	DT
cord-015021-pol2qm74	2257	28	controls	control	NNS
cord-015021-pol2qm74	2257	29	and	and	CC
cord-015021-pol2qm74	2257	30	excess	excess	JJ
cord-015021-pol2qm74	2257	31	leucocyte	leucocyte	JJ
cord-015021-pol2qm74	2257	32	infiltration	infiltration	NN
cord-015021-pol2qm74	2257	33	was	be	VBD
cord-015021-pol2qm74	2257	34	noted	note	VBN
cord-015021-pol2qm74	2257	35	at	at	IN
cord-015021-pol2qm74	2257	36	the	the	DT
cord-015021-pol2qm74	2257	37	infarction	infarction	NN
cord-015021-pol2qm74	2257	38	zone	zone	NN
cord-015021-pol2qm74	2257	39	.	.	.
cord-015021-pol2qm74	2258	1	In	in	IN
cord-015021-pol2qm74	2258	2	second	second	JJ
cord-015021-pol2qm74	2258	3	instance	instance	NN
cord-015021-pol2qm74	2258	4	two	two	CD
cord-015021-pol2qm74	2258	5	levels	level	NNS
cord-015021-pol2qm74	2258	6	of	of	IN
cord-015021-pol2qm74	2258	7	LT	LT	NNP
cord-015021-pol2qm74	2258	8	B4	B4	NNP
cord-015021-pol2qm74	2258	9	led	lead	VBD
cord-015021-pol2qm74	2258	10	to	to	IN
cord-015021-pol2qm74	2258	11	weak	weak	JJ
cord-015021-pol2qm74	2258	12	infiltration	infiltration	NN
cord-015021-pol2qm74	2258	13	of	of	IN
cord-015021-pol2qm74	2258	14	the	the	DT
cord-015021-pol2qm74	2258	15	infarction	infarction	NN
cord-015021-pol2qm74	2258	16	zone	zone	NN
cord-015021-pol2qm74	2258	17	by	by	IN
cord-015021-pol2qm74	2258	18	leucocytes	leucocytes	NNP
cord-015021-pol2qm74	2258	19	.	.	.
cord-015021-pol2qm74	2259	1	A.	A.	NNP
cord-015021-pol2qm74	2259	2	Mo	Mo	NNP
cord-015021-pol2qm74	2260	1	~e	~e	NNP
cord-015021-pol2qm74	2260	2	~	~	NFP
cord-015021-pol2qm74	2260	3	o	o	UH
cord-015021-pol2qm74	2260	4	,	,	,
cord-015021-pol2qm74	2260	5	In~.~P	in~.~p	NN
cord-015021-pol2qm74	2260	6	~	~	NFP
cord-015021-pol2qm74	2260	7	siolo~,D	siolo~,D	NNP
cord-015021-pol2qm74	2260	8	~	~	NFP
cord-015021-pol2qm74	2260	9	t	t	NN
cord-015021-pol2qm74	2260	10	.	.	.
cord-015021-pol2qm74	2261	1	E~.Cardiolo~,Bogotsolets4	E~.Cardiolo~,Bogotsolets4	NNP
cord-015021-pol2qm74	2261	2	,	,	,
cord-015021-pol2qm74	2261	3	~ev252024	~ev252024	NNP
cord-015021-pol2qm74	2261	4	,	,	,
cord-015021-pol2qm74	2261	5	Ukrmne	Ukrmne	NNP
cord-015021-pol2qm74	2261	6	Systemic	Systemic	NNP
cord-015021-pol2qm74	2262	1	lesion$of	lesion$of	CC
cord-015021-pol2qm74	2262	2	erythron	erythron	NNP
cord-015021-pol2qm74	2262	3	in	in	IN
cord-015021-pol2qm74	2262	4	traumatic	traumatic	JJ
cord-015021-pol2qm74	2262	5	disease	disease	NN
cord-015021-pol2qm74	2262	6	and	and	CC
cord-015021-pol2qm74	2262	7	possibilities	possibility	NNS
cord-015021-pol2qm74	2262	8	of	of	IN
cord-015021-pol2qm74	2262	9	their	-PRON-	PRP$
cord-015021-pol2qm74	2262	10	regulation	regulation	NN
cord-015021-pol2qm74	2262	11	by	by	IN
cord-015021-pol2qm74	2262	12	opioid	opioid	JJ
cord-015021-pol2qm74	2262	13	peptides	peptide	NNS
cord-015021-pol2qm74	2262	14	.	.	.
cord-015021-pol2qm74	2263	1	Redkin	Redkin	NNP
cord-015021-pol2qm74	2263	2	Y.	Y.	NNP
cord-015021-pol2qm74	2263	3	V.	V.	NNP
cord-015021-pol2qm74	2263	4	,	,	,
cord-015021-pol2qm74	2263	5	Fominih	Fominih	NNP
cord-015021-pol2qm74	2263	6	S.	S.	NNP
cord-015021-pol2qm74	2263	7	G.	G.	NNP
cord-015021-pol2qm74	2264	1	Using	use	VBG
cord-015021-pol2qm74	2264	2	clinical	clinical	JJ
cord-015021-pol2qm74	2264	3	(	(	-LRB-
cord-015021-pol2qm74	2264	4	121	121	CD
cord-015021-pol2qm74	2264	5	patients	patient	NNS
cord-015021-pol2qm74	2264	6	)	)	-RRB-
cord-015021-pol2qm74	2264	7	and	and	CC
cord-015021-pol2qm74	2264	8	experimental	experimental	JJ
cord-015021-pol2qm74	2264	9	material(128	material(128	JJ
cord-015021-pol2qm74	2264	10	rats	rat	NNS
cord-015021-pol2qm74	2264	11	and	and	CC
cord-015021-pol2qm74	2264	12	74	74	CD
cord-015021-pol2qm74	2264	13	dogs	dog	NNS
cord-015021-pol2qm74	2264	14	)	)	-RRB-
cord-015021-pol2qm74	2264	15	we	-PRON-	PRP
cord-015021-pol2qm74	2264	16	revealed	reveal	VBD
cord-015021-pol2qm74	2264	17	general	general	JJ
cord-015021-pol2qm74	2264	18	regularities	regularity	NNS
cord-015021-pol2qm74	2264	19	of	of	IN
cord-015021-pol2qm74	2264	20	erythron	erythron	NNP
cord-015021-pol2qm74	2264	21	lesions	lesion	NNS
cord-015021-pol2qm74	2264	22	after	after	IN
cord-015021-pol2qm74	2264	23	hard	hard	JJ
cord-015021-pol2qm74	2264	24	mechanical	mechanical	JJ
cord-015021-pol2qm74	2264	25	trauma	trauma	NN
cord-015021-pol2qm74	2264	26	of	of	IN
cord-015021-pol2qm74	2264	27	various	various	JJ
cord-015021-pol2qm74	2264	28	genesis	genesis	NN
cord-015021-pol2qm74	2264	29	as	as	RB
cord-015021-pol2qm74	2264	30	well	well	RB
cord-015021-pol2qm74	2264	31	as	as	IN
cord-015021-pol2qm74	2264	32	some	some	DT
cord-015021-pol2qm74	2264	33	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2264	34	of	of	IN
cord-015021-pol2qm74	2264	35	development	development	NN
cord-015021-pol2qm74	2264	36	of	of	IN
cord-015021-pol2qm74	2264	37	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	2264	38	anemia	anemia	NN
cord-015021-pol2qm74	2264	39	and	and	CC
cord-015021-pol2qm74	2264	40	possibilities	possibility	NNS
cord-015021-pol2qm74	2264	41	of	of	IN
cord-015021-pol2qm74	2264	42	its	-PRON-	PRP$
cord-015021-pol2qm74	2264	43	correction	correction	NN
cord-015021-pol2qm74	2264	44	with	with	IN
cord-015021-pol2qm74	2264	45	preparations	preparation	NNS
cord-015021-pol2qm74	2264	46	of	of	IN
cord-015021-pol2qm74	2264	47	opioid	opioid	JJ
cord-015021-pol2qm74	2264	48	peptides	peptide	NNS
cord-015021-pol2qm74	2264	49	.	.	.
cord-015021-pol2qm74	2265	1	The	the	DT
cord-015021-pol2qm74	2265	2	condition	condition	NN
cord-015021-pol2qm74	2265	3	of	of	IN
cord-015021-pol2qm74	2265	4	central	central	JJ
cord-015021-pol2qm74	2265	5	and	and	CC
cord-015021-pol2qm74	2265	6	peripheral	peripheral	JJ
cord-015021-pol2qm74	2265	7	compartments	compartment	NNS
cord-015021-pol2qm74	2265	8	of	of	IN
cord-015021-pol2qm74	2265	9	erythron	erythron	NNP
cord-015021-pol2qm74	2265	10	was	be	VBD
cord-015021-pol2qm74	2265	11	studied	study	VBN
cord-015021-pol2qm74	2265	12	with	with	IN
cord-015021-pol2qm74	2265	13	unified	unified	JJ
cord-015021-pol2qm74	2265	14	morphologic	morphologic	JJ
cord-015021-pol2qm74	2265	15	,	,	,
cord-015021-pol2qm74	2265	16	immunogematological	immunogematological	JJ
cord-015021-pol2qm74	2265	17	,	,	,
cord-015021-pol2qm74	2265	18	biochemical	biochemical	JJ
cord-015021-pol2qm74	2265	19	and	and	CC
cord-015021-pol2qm74	2265	20	radiological	radiological	JJ
cord-015021-pol2qm74	2265	21	methods	method	NNS
cord-015021-pol2qm74	2265	22	.	.	.
cord-015021-pol2qm74	2266	1	It	-PRON-	PRP
cord-015021-pol2qm74	2266	2	was	be	VBD
cord-015021-pol2qm74	2266	3	revealed	reveal	VBN
cord-015021-pol2qm74	2266	4	that	that	IN
cord-015021-pol2qm74	2266	5	irrespective	irrespective	RB
cord-015021-pol2qm74	2266	6	of	of	IN
cord-015021-pol2qm74	2266	7	the	the	DT
cord-015021-pol2qm74	2266	8	experimental	experimental	JJ
cord-015021-pol2qm74	2266	9	animal	animal	NN
cord-015021-pol2qm74	2266	10	species	specie	NNS
cord-015021-pol2qm74	2266	11	(	(	-LRB-
cord-015021-pol2qm74	2266	12	dogs	dog	NNS
cord-015021-pol2qm74	2266	13	,	,	,
cord-015021-pol2qm74	2266	14	rats	rat	NNS
cord-015021-pol2qm74	2266	15	)	)	-RRB-
cord-015021-pol2qm74	2266	16	or	or	CC
cord-015021-pol2qm74	2266	17	in	in	IN
cord-015021-pol2qm74	2266	18	clinical	clinical	JJ
cord-015021-pol2qm74	2266	19	experiments	experiment	NNS
cord-015021-pol2qm74	2266	20	(	(	-LRB-
cord-015021-pol2qm74	2266	21	patients	patient	NNS
cord-015021-pol2qm74	2266	22	)	)	-RRB-
cord-015021-pol2qm74	2266	23	and	and	CC
cord-015021-pol2qm74	2266	24	irrespective	irrespective	RB
cord-015021-pol2qm74	2266	25	of	of	IN
cord-015021-pol2qm74	2266	26	the	the	DT
cord-015021-pol2qm74	2266	27	injuring	injure	VBG
cord-015021-pol2qm74	2266	28	factor	factor	NN
cord-015021-pol2qm74	2266	29	type	type	NN
cord-015021-pol2qm74	2266	30	(	(	-LRB-
cord-015021-pol2qm74	2266	31	skeletal	skeletal	JJ
cord-015021-pol2qm74	2266	32	trauma	trauma	NN
cord-015021-pol2qm74	2266	33	,	,	,
cord-015021-pol2qm74	2266	34	craniocerebral	craniocerebral	NNP
cord-015021-pol2qm74	2266	35	trauma	trauma	NN
cord-015021-pol2qm74	2266	36	,	,	,
cord-015021-pol2qm74	2266	37	loss	loss	NN
cord-015021-pol2qm74	2266	38	of	of	IN
cord-015021-pol2qm74	2266	39	blood	blood	NN
cord-015021-pol2qm74	2266	40	)	)	-RRB-
cord-015021-pol2qm74	2266	41	in	in	IN
cord-015021-pol2qm74	2266	42	erythron	erythron	NNP
cord-015021-pol2qm74	2266	43	can	can	MD
cord-015021-pol2qm74	2266	44	be	be	VB
cord-015021-pol2qm74	2266	45	observed	observe	VBN
cord-015021-pol2qm74	2266	46	one	one	CD
cord-015021-pol2qm74	2266	47	-	-	HYPH
cord-015021-pol2qm74	2266	48	directed	direct	VBN
cord-015021-pol2qm74	2266	49	unspecific	unspecific	JJ
cord-015021-pol2qm74	2266	50	reaction	reaction	NN
cord-015021-pol2qm74	2266	51	realized	realize	VBN
cord-015021-pol2qm74	2266	52	by	by	IN
cord-015021-pol2qm74	2266	53	the	the	DT
cord-015021-pol2qm74	2266	54	considerable	considerable	JJ
cord-015021-pol2qm74	2266	55	lowering	lowering	NN
cord-015021-pol2qm74	2266	56	of	of	IN
cord-015021-pol2qm74	2266	57	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	2266	58	concentration	concentration	NN
cord-015021-pol2qm74	2266	59	,	,	,
cord-015021-pol2qm74	2266	60	erythrocytes	erythrocyte	VBZ
cord-015021-pol2qm74	2266	61	number	number	NN
cord-015021-pol2qm74	2266	62	and	and	CC
cord-015021-pol2qm74	2266	63	hematocrit	hematocrit	NN
cord-015021-pol2qm74	2266	64	.	.	.
cord-015021-pol2qm74	2267	1	In	in	IN
cord-015021-pol2qm74	2267	2	the	the	DT
cord-015021-pol2qm74	2267	3	initial	initial	JJ
cord-015021-pol2qm74	2267	4	period	period	NN
cord-015021-pol2qm74	2267	5	(	(	-LRB-
cord-015021-pol2qm74	2267	6	1	1	CD
cord-015021-pol2qm74	2267	7	-	-	SYM
cord-015021-pol2qm74	2267	8	7	7	CD
cord-015021-pol2qm74	2267	9	days	day	NNS
cord-015021-pol2qm74	2267	10	)	)	-RRB-
cord-015021-pol2qm74	2267	11	in	in	IN
cord-015021-pol2qm74	2267	12	the	the	DT
cord-015021-pol2qm74	2267	13	system	system	NN
cord-015021-pol2qm74	2267	14	of	of	IN
cord-015021-pol2qm74	2267	15	erythron	erythron	NNP
cord-015021-pol2qm74	2267	16	prevail	prevail	VBP
cord-015021-pol2qm74	2267	17	processes	process	NNS
cord-015021-pol2qm74	2267	18	of	of	IN
cord-015021-pol2qm74	2267	19	distraction	distraction	NN
cord-015021-pol2qm74	2267	20	and	and	CC
cord-015021-pol2qm74	2267	21	elimination	elimination	NN
cord-015021-pol2qm74	2267	22	of	of	IN
cord-015021-pol2qm74	2267	23	er	er	UH
cord-015021-pol2qm74	2267	24	~	~	NFP
cord-015021-pol2qm74	2267	25	zthrocytes	zthrocytes	XX
cord-015021-pol2qm74	2267	26	relatively	relatively	RB
cord-015021-pol2qm74	2267	27	to	to	IN
cord-015021-pol2qm74	2267	28	the	the	DT
cord-015021-pol2qm74	2267	29	general	general	JJ
cord-015021-pol2qm74	2267	30	production	production	NN
cord-015021-pol2qm74	2267	31	of	of	IN
cord-015021-pol2qm74	2267	32	stimulated	stimulate	VBN
cord-015021-pol2qm74	2267	33	erythropoiesis	erythropoiesis	NN
cord-015021-pol2qm74	2267	34	.	.	.
cord-015021-pol2qm74	2268	1	The	the	DT
cord-015021-pol2qm74	2268	2	primary	primary	JJ
cord-015021-pol2qm74	2268	3	alterating	alterating	NN
cord-015021-pol2qm74	2268	4	factor	factor	NN
cord-015021-pol2qm74	2268	5	is	be	VBZ
cord-015021-pol2qm74	2268	6	the	the	DT
cord-015021-pol2qm74	2268	7	prolonged	prolonged	JJ
cord-015021-pol2qm74	2268	8	intensification	intensification	NN
cord-015021-pol2qm74	2268	9	of	of	IN
cord-015021-pol2qm74	2268	10	peroxydation	peroxydation	NN
cord-015021-pol2qm74	2268	11	of	of	IN
cord-015021-pol2qm74	2268	12	membrane	membrane	NN
cord-015021-pol2qm74	2268	13	iipids	iipid	NNS
cord-015021-pol2qm74	2268	14	of	of	IN
cord-015021-pol2qm74	2268	15	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	2268	16	with	with	IN
cord-015021-pol2qm74	2268	17	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	2268	18	lowering	lowering	NN
cord-015021-pol2qm74	2268	19	of	of	IN
cord-015021-pol2qm74	2268	20	reserves	reserve	NNS
cord-015021-pol2qm74	2268	21	of	of	IN
cord-015021-pol2qm74	2268	22	reduced	reduce	VBN
cord-015021-pol2qm74	2268	23	glutathione	glutathione	NN
cord-015021-pol2qm74	2268	24	.	.	.
cord-015021-pol2qm74	2269	1	The	the	DT
cord-015021-pol2qm74	2269	2	distraction	distraction	NN
cord-015021-pol2qm74	2269	3	of	of	IN
cord-015021-pol2qm74	2269	4	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	2269	5	is	be	VBZ
cord-015021-pol2qm74	2269	6	supported	support	VBN
cord-015021-pol2qm74	2269	7	by	by	IN
cord-015021-pol2qm74	2269	8	the	the	DT
cord-015021-pol2qm74	2269	9	developing	develop	VBG
cord-015021-pol2qm74	2269	10	phenomena	phenomenon	NNS
cord-015021-pol2qm74	2269	11	of	of	IN
cord-015021-pol2qm74	2269	12	autoallergization	autoallergization	NN
cord-015021-pol2qm74	2269	13	of	of	IN
cord-015021-pol2qm74	2269	14	organism	organism	NN
cord-015021-pol2qm74	2269	15	that	that	WDT
cord-015021-pol2qm74	2269	16	becomes	become	VBZ
cord-015021-pol2qm74	2269	17	apparent	apparent	JJ
cord-015021-pol2qm74	2269	18	by	by	IN
cord-015021-pol2qm74	2269	19	the	the	DT
cord-015021-pol2qm74	2269	20	appearance	appearance	NN
cord-015021-pol2qm74	2269	21	of	of	IN
cord-015021-pol2qm74	2269	22	sensitized	sensitize	VBN
cord-015021-pol2qm74	2269	23	T	T	NNP
cord-015021-pol2qm74	2269	24	cells	cell	NNS
cord-015021-pol2qm74	2269	25	and	and	CC
cord-015021-pol2qm74	2269	26	antierythrocyte	antierythrocyte	NNP
cord-015021-pol2qm74	2269	27	antibodies	antibody	NNS
cord-015021-pol2qm74	2269	28	.	.	.
cord-015021-pol2qm74	2270	1	The	the	DT
cord-015021-pol2qm74	2270	2	intensified	intensify	VBN
cord-015021-pol2qm74	2270	3	production	production	NN
cord-015021-pol2qm74	2270	4	of	of	IN
cord-015021-pol2qm74	2270	5	erythropoietin	erythropoietin	NN
cord-015021-pol2qm74	2270	6	rules	rule	NNS
cord-015021-pol2qm74	2270	7	to	to	IN
cord-015021-pol2qm74	2270	8	the	the	DT
cord-015021-pol2qm74	2270	9	realization	realization	NN
cord-015021-pol2qm74	2270	10	of	of	IN
cord-015021-pol2qm74	2270	11	he	-PRON-	PRP
cord-015021-pol2qm74	2270	12	program	program	NN
cord-015021-pol2qm74	2270	13	of	of	IN
cord-015021-pol2qm74	2270	14	fetal	fetal	JJ
cord-015021-pol2qm74	2270	15	and	and	CC
cord-015021-pol2qm74	2270	16	terminal	terminal	JJ
cord-015021-pol2qm74	2270	17	(	(	-LRB-
cord-015021-pol2qm74	2270	18	reserved	reserved	JJ
cord-015021-pol2qm74	2270	19	)	)	-RRB-
cord-015021-pol2qm74	2270	20	erythropoiesis	erythropoiesis	NN
cord-015021-pol2qm74	2270	21	.	.	.
cord-015021-pol2qm74	2271	1	Failure	failure	NN
cord-015021-pol2qm74	2271	2	of	of	IN
cord-015021-pol2qm74	2271	3	erythropoiesis	erythropoiesis	NN
cord-015021-pol2qm74	2271	4	function	function	NN
cord-015021-pol2qm74	2271	5	is	be	VBZ
cord-015021-pol2qm74	2271	6	supported	support	VBN
cord-015021-pol2qm74	2271	7	by	by	IN
cord-015021-pol2qm74	2271	8	disturbances	disturbance	NNS
cord-015021-pol2qm74	2271	9	of	of	IN
cord-015021-pol2qm74	2271	10	the	the	DT
cord-015021-pol2qm74	2271	11	processes	process	NNS
cord-015021-pol2qm74	2271	12	of	of	IN
cord-015021-pol2qm74	2271	13	the	the	DT
cord-015021-pol2qm74	2271	14	injuring	injuring	NN
cord-015021-pol2qm74	2271	15	of	of	IN
cord-015021-pol2qm74	2271	16	cell	cell	NN
cord-015021-pol2qm74	2271	17	metabolic	metabolic	JJ
cord-015021-pol2qm74	2271	18	apparatus	apparatus	NN
cord-015021-pol2qm74	2271	19	.	.	.
cord-015021-pol2qm74	2272	1	Using	use	VBG
cord-015021-pol2qm74	2272	2	of	of	IN
cord-015021-pol2qm74	2272	3	dalargin	dalargin	NNP
cord-015021-pol2qm74	2272	4	(	(	-LRB-
cord-015021-pol2qm74	2272	5	15	15	CD
cord-015021-pol2qm74	2272	6	microgram	microgram	NN
cord-015021-pol2qm74	2272	7	per	per	IN
cord-015021-pol2qm74	2272	8	kilogram	kilogram	NN
cord-015021-pol2qm74	2272	9	of	of	IN
cord-015021-pol2qm74	2272	10	body	body	NN
cord-015021-pol2qm74	2272	11	mass	mass	NN
cord-015021-pol2qm74	2272	12	intrap'eritoneally	intrap'eritoneally	NN
cord-015021-pol2qm74	2272	13	within	within	IN
cord-015021-pol2qm74	2272	14	5	5	CD
cord-015021-pol2qm74	2272	15	days	day	NNS
cord-015021-pol2qm74	2272	16	after	after	IN
cord-015021-pol2qm74	2272	17	the	the	DT
cord-015021-pol2qm74	2272	18	trauma	trauma	NN
cord-015021-pol2qm74	2272	19	)	)	-RRB-
cord-015021-pol2qm74	2272	20	showed	show	VBD
cord-015021-pol2qm74	2272	21	the	the	DT
cord-015021-pol2qm74	2272	22	precise	precise	JJ
cord-015021-pol2qm74	2272	23	pharmacotherapeutic	pharmacotherapeutic	JJ
cord-015021-pol2qm74	2272	24	effect	effect	NN
cord-015021-pol2qm74	2272	25	revealed	reveal	VBN
cord-015021-pol2qm74	2272	26	by	by	IN
cord-015021-pol2qm74	2272	27	the	the	DT
cord-015021-pol2qm74	2272	28	diminishing	diminishing	NN
cord-015021-pol2qm74	2272	29	of	of	IN
cord-015021-pol2qm74	2272	30	anemia	anemia	NN
cord-015021-pol2qm74	2272	31	of	of	IN
cord-015021-pol2qm74	2272	32	experimental	experimental	JJ
cord-015021-pol2qm74	2272	33	rats	rat	NNS
cord-015021-pol2qm74	2272	34	,	,	,
cord-015021-pol2qm74	2272	35	more	more	JJR
cord-015021-pol2qm74	2272	36	.	.	.
cord-015021-pol2qm74	2273	1	Fiberbronohoscopic	Fiberbronohoscopic	NNP
cord-015021-pol2qm74	2273	2	procedures	procedure	NNS
cord-015021-pol2qm74	2273	3	are	be	VBP
cord-015021-pol2qm74	2273	4	known	know	VBN
cord-015021-pol2qm74	2273	5	to	to	TO
cord-015021-pol2qm74	2273	6	produce	produce	VB
cord-015021-pol2qm74	2273	7	"	"	``
cord-015021-pol2qm74	2273	8	PEEP	peep	NN
cord-015021-pol2qm74	2273	9	-	-	HYPH
cord-015021-pol2qm74	2273	10	like	like	JJ
cord-015021-pol2qm74	2273	11	"	"	``
cord-015021-pol2qm74	2273	12	effects	effect	NNS
cord-015021-pol2qm74	2273	13	and	and	CC
cord-015021-pol2qm74	2273	14	to	to	TO
cord-015021-pol2qm74	2273	15	increase	increase	VB
cord-015021-pol2qm74	2273	16	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2273	17	artery	artery	NN
cord-015021-pol2qm74	2273	18	(	(	-LRB-
cord-015021-pol2qm74	2273	19	PA	PA	NNP
cord-015021-pol2qm74	2273	20	)	)	-RRB-
cord-015021-pol2qm74	2273	21	resistance	resistance	NN
cord-015021-pol2qm74	2273	22	[	[	-LRB-
cord-015021-pol2qm74	2273	23	2	2	CD
cord-015021-pol2qm74	2273	24	]	]	-RRB-
cord-015021-pol2qm74	2273	25	.	.	.
cord-015021-pol2qm74	2274	1	PEEP	PEEP	NNP
cord-015021-pol2qm74	2274	2	can	can	MD
cord-015021-pol2qm74	2274	3	affect	affect	VB
cord-015021-pol2qm74	2274	4	RV	RV	NNP
cord-015021-pol2qm74	2274	5	function	function	NN
cord-015021-pol2qm74	2274	6	by	by	IN
cord-015021-pol2qm74	2274	7	reducing	reduce	VBG
cord-015021-pol2qm74	2274	8	preload	preload	NN
cord-015021-pol2qm74	2274	9	and	and	CC
cord-015021-pol2qm74	2274	10	ejection	ejection	NN
cord-015021-pol2qm74	2274	11	fraction	fraction	NN
cord-015021-pol2qm74	2274	12	(	(	-LRB-
cord-015021-pol2qm74	2274	13	EF	EF	NNP
cord-015021-pol2qm74	2274	14	)	)	-RRB-
cord-015021-pol2qm74	2274	15	[	[	-LRB-
cord-015021-pol2qm74	2274	16	3	3	CD
cord-015021-pol2qm74	2274	17	]	]	-RRB-
cord-015021-pol2qm74	2274	18	.	.	.
cord-015021-pol2qm74	2275	1	Since	since	IN
cord-015021-pol2qm74	2275	2	changes	change	NNS
cord-015021-pol2qm74	2275	3	of	of	IN
cord-015021-pol2qm74	2275	4	RV	RV	NNP
cord-015021-pol2qm74	2275	5	function	function	NN
cord-015021-pol2qm74	2275	6	during	during	IN
cord-015021-pol2qm74	2275	7	bronchoscopy	bronchoscopy	NN
cord-015021-pol2qm74	2275	8	in	in	IN
cord-015021-pol2qm74	2275	9	septic	septic	JJ
cord-015021-pol2qm74	2275	10	patients	patient	NNS
cord-015021-pol2qm74	2275	11	are	be	VBP
cord-015021-pol2qm74	2275	12	not	not	RB
cord-015021-pol2qm74	2275	13	reported	report	VBN
cord-015021-pol2qm74	2275	14	,	,	,
cord-015021-pol2qm74	2275	15	we	-PRON-	PRP
cord-015021-pol2qm74	2275	16	measured	measure	VBD
cord-015021-pol2qm74	2275	17	RV	RV	NNP
cord-015021-pol2qm74	2275	18	parameters	parameter	NNS
cord-015021-pol2qm74	2275	19	before	before	RB
cord-015021-pol2qm74	2275	20	,	,	,
cord-015021-pol2qm74	2275	21	during	during	IN
cord-015021-pol2qm74	2275	22	and	and	CC
cord-015021-pol2qm74	2275	23	after	after	IN
cord-015021-pol2qm74	2275	24	fiberoptic	fiberoptic	JJ
cord-015021-pol2qm74	2275	25	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	2275	26	lavage	lavage	NN
cord-015021-pol2qm74	2275	27	(	(	-LRB-
cord-015021-pol2qm74	2275	28	BAL	BAL	NNP
cord-015021-pol2qm74	2275	29	)	)	-RRB-
cord-015021-pol2qm74	2275	30	.	.	.
cord-015021-pol2qm74	2276	1	Method	method	NN
cord-015021-pol2qm74	2276	2	:	:	:
cord-015021-pol2qm74	2277	1	This	this	DT
cord-015021-pol2qm74	2277	2	34-year	34-year	JJ
cord-015021-pol2qm74	2277	3	-	-	HYPH
cord-015021-pol2qm74	2277	4	old	old	JJ
cord-015021-pol2qm74	2277	5	patient	patient	NN
cord-015021-pol2qm74	2277	6	(	(	-LRB-
cord-015021-pol2qm74	2277	7	APACHE	APACHE	NNP
cord-015021-pol2qm74	2277	8	-	-	HYPH
cord-015021-pol2qm74	2277	9	II:24	II:24	NNP
cord-015021-pol2qm74	2277	10	)	)	-RRB-
cord-015021-pol2qm74	2277	11	developed	develop	VBD
cord-015021-pol2qm74	2277	12	a	a	DT
cord-015021-pol2qm74	2277	13	hyperdynanlic	hyperdynanlic	JJ
cord-015021-pol2qm74	2277	14	septic	septic	JJ
cord-015021-pol2qm74	2277	15	state	state	NN
cord-015021-pol2qm74	2277	16	due	due	JJ
cord-015021-pol2qm74	2277	17	to	to	IN
cord-015021-pol2qm74	2277	18	Staphylococcus	Staphylococcus	NNP
cord-015021-pol2qm74	2277	19	aureus	aureus	NN
cord-015021-pol2qm74	2277	20	(	(	-LRB-
cord-015021-pol2qm74	2277	21	blood	blood	NN
cord-015021-pol2qm74	2277	22	culture	culture	NN
cord-015021-pol2qm74	2277	23	)	)	-RRB-
cord-015021-pol2qm74	2277	24	.	.	.
cord-015021-pol2qm74	2278	1	We	-PRON-	PRP
cord-015021-pol2qm74	2278	2	inserted	insert	VBD
cord-015021-pol2qm74	2278	3	a	a	DT
cord-015021-pol2qm74	2278	4	"	"	``
cord-015021-pol2qm74	2278	5	fast	fast	JJ
cord-015021-pol2qm74	2278	6	response	response	NN
cord-015021-pol2qm74	2278	7	"	"	''
cord-015021-pol2qm74	2278	8	thermistor	thermistor	NN
cord-015021-pol2qm74	2278	9	PA	PA	NNP
cord-015021-pol2qm74	2278	10	-	-	HYPH
cord-015021-pol2qm74	2278	11	catheter	catheter	NNP
cord-015021-pol2qm74	2278	12	(	(	-LRB-
cord-015021-pol2qm74	2278	13	Baxter	Baxter	NNP
cord-015021-pol2qm74	2278	14	-	-	HYPH
cord-015021-pol2qm74	2278	15	Edwards	Edwards	NNP
cord-015021-pol2qm74	2278	16	)	)	-RRB-
cord-015021-pol2qm74	2278	17	to	to	TO
cord-015021-pol2qm74	2278	18	evaluate	evaluate	VB
cord-015021-pol2qm74	2278	19	RV	rv	NN
cord-015021-pol2qm74	2278	20	performance	performance	NN
cord-015021-pol2qm74	2278	21	[	[	-LRB-
cord-015021-pol2qm74	2278	22	4	4	CD
cord-015021-pol2qm74	2278	23	]	]	-RRB-
cord-015021-pol2qm74	2278	24	.	.	.
cord-015021-pol2qm74	2279	1	The	the	DT
cord-015021-pol2qm74	2279	2	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	2279	3	procedure	procedure	NN
cord-015021-pol2qm74	2279	4	included	include	VBD
cord-015021-pol2qm74	2279	5	volume	volume	NN
cord-015021-pol2qm74	2279	6	replacement	replacement	NN
cord-015021-pol2qm74	2279	7	,	,	,
cord-015021-pol2qm74	2279	8	vasopressors	vasopressor	NNS
cord-015021-pol2qm74	2279	9	(	(	-LRB-
cord-015021-pol2qm74	2279	10	dopamine	dopamine	NN
cord-015021-pol2qm74	2279	11	5	5	CD
cord-015021-pol2qm74	2279	12	,	,	,
cord-015021-pol2qm74	2279	13	dobutamine	dobutamine	NNP
cord-015021-pol2qm74	2279	14	3	3	CD
cord-015021-pol2qm74	2279	15	gg	gg	NNP
cord-015021-pol2qm74	2279	16	/	/	SYM
cord-015021-pol2qm74	2279	17	kg	kg	NNP
cord-015021-pol2qm74	2279	18	/	/	SYM
cord-015021-pol2qm74	2279	19	min	min	NN
cord-015021-pol2qm74	2279	20	.	.	.
cord-015021-pol2qm74	2279	21	IV	IV	NNP
cord-015021-pol2qm74	2279	22	)	)	-RRB-
cord-015021-pol2qm74	2279	23	and	and	CC
cord-015021-pol2qm74	2280	1	analgosedatior/.	analgosedatior/.	CC
cord-015021-pol2qm74	2280	2	Before	before	IN
cord-015021-pol2qm74	2280	3	bronchoscopy	bronchoscopy	NN
cord-015021-pol2qm74	2280	4	(	(	-LRB-
cord-015021-pol2qm74	2280	5	Olympus	Olympus	NNP
cord-015021-pol2qm74	2280	6	BF-30	BF-30	NNP
cord-015021-pol2qm74	2280	7	,	,	,
cord-015021-pol2qm74	2280	8	OD=6	OD=6	NNP
cord-015021-pol2qm74	2280	9	mm	mm	NNP
cord-015021-pol2qm74	2280	10	)	)	-RRB-
cord-015021-pol2qm74	2280	11	the	the	DT
cord-015021-pol2qm74	2280	12	patient	patient	NN
cord-015021-pol2qm74	2280	13	received	receive	VBD
cord-015021-pol2qm74	2280	14	pancmonium	pancmonium	NN
cord-015021-pol2qm74	2280	15	for	for	IN
cord-015021-pol2qm74	2280	16	muscle	muscle	NN
cord-015021-pol2qm74	2280	17	relaxation	relaxation	NN
cord-015021-pol2qm74	2280	18	.	.	.
cord-015021-pol2qm74	2281	1	Ventilation	ventilation	NN
cord-015021-pol2qm74	2281	2	was	be	VBD
cord-015021-pol2qm74	2281	3	not	not	RB
cord-015021-pol2qm74	2281	4	changed	change	VBN
cord-015021-pol2qm74	2281	5	during	during	IN
cord-015021-pol2qm74	2281	6	the	the	DT
cord-015021-pol2qm74	2281	7	procedure	procedure	NN
cord-015021-pol2qm74	2281	8	(	(	-LRB-
cord-015021-pol2qm74	2281	9	endotracheal	endotracheal	NN
cord-015021-pol2qm74	2281	10	tube	tube	NN
cord-015021-pol2qm74	2281	11	:	:	:
cord-015021-pol2qm74	2281	12	ID=8	id=8	NN
cord-015021-pol2qm74	2281	13	ram	ram	NN
cord-015021-pol2qm74	2281	14	,	,	,
cord-015021-pol2qm74	2281	15	Bennett	Bennett	NNP
cord-015021-pol2qm74	2281	16	7200a	7200a	CD
cord-015021-pol2qm74	2281	17	,	,	,
cord-015021-pol2qm74	2281	18	pressure	pressure	NN
cord-015021-pol2qm74	2281	19	controlled	control	VBN
cord-015021-pol2qm74	2281	20	mode	mode	NN
cord-015021-pol2qm74	2281	21	,	,	,
cord-015021-pol2qm74	2282	1	Pm	pm	NN
cord-015021-pol2qm74	2282	2	~	~	CD
cord-015021-pol2qm74	2282	3	x=25	x=25	NN
cord-015021-pol2qm74	2282	4	mbar	mbar	NN
cord-015021-pol2qm74	2282	5	,	,	,
cord-015021-pol2qm74	2282	6	PEEP=8	peep=8	NN
cord-015021-pol2qm74	2282	7	mbar	mbar	NN
cord-015021-pol2qm74	2282	8	,	,	,
cord-015021-pol2qm74	2282	9	I	i	NN
cord-015021-pol2qm74	2282	10	:	:	:
cord-015021-pol2qm74	2282	11	E	e	NN
cord-015021-pol2qm74	2282	12	=	=	NN
cord-015021-pol2qm74	2282	13	I	i	NN
cord-015021-pol2qm74	2282	14	:	:	:
cord-015021-pol2qm74	2282	15	I	-PRON-	PRP
cord-015021-pol2qm74	2282	16	,	,	,
cord-015021-pol2qm74	2282	17	FiO2=1.0	FiO2=1.0	NNP
cord-015021-pol2qm74	2282	18	)	)	-RRB-
cord-015021-pol2qm74	2282	19	.	.	.
cord-015021-pol2qm74	2283	1	We	-PRON-	PRP
cord-015021-pol2qm74	2283	2	measured	measure	VBD
cord-015021-pol2qm74	2283	3	RV	RV	NNP
cord-015021-pol2qm74	2283	4	enddiastolic	enddiastolic	NN
cord-015021-pol2qm74	2283	5	volume	volume	NN
cord-015021-pol2qm74	2283	6	(	(	-LRB-
cord-015021-pol2qm74	2283	7	EDV	EDV	NNP
cord-015021-pol2qm74	2283	8	)	)	-RRB-
cord-015021-pol2qm74	2283	9	,	,	,
cord-015021-pol2qm74	2283	10	stroke	stroke	NN
cord-015021-pol2qm74	2283	11	volume	volume	NN
cord-015021-pol2qm74	2283	12	(	(	-LRB-
cord-015021-pol2qm74	2283	13	SV	SV	NNP
cord-015021-pol2qm74	2283	14	)	)	-RRB-
cord-015021-pol2qm74	2283	15	,	,	,
cord-015021-pol2qm74	2283	16	EF	EF	NNP
cord-015021-pol2qm74	2283	17	,	,	,
cord-015021-pol2qm74	2283	18	heart	heart	NN
cord-015021-pol2qm74	2283	19	rate	rate	NN
cord-015021-pol2qm74	2283	20	(	(	-LRB-
cord-015021-pol2qm74	2283	21	HR	HR	NNP
cord-015021-pol2qm74	2283	22	)	)	-RRB-
cord-015021-pol2qm74	2283	23	,	,	.
cord-015021-pol2qm74	2284	1	cardiac	cardiac	JJ
cord-015021-pol2qm74	2284	2	index	index	NN
cord-015021-pol2qm74	2284	3	(	(	-LRB-
cord-015021-pol2qm74	2284	4	CI	CI	NNP
cord-015021-pol2qm74	2284	5	)	)	-RRB-
cord-015021-pol2qm74	2284	6	and	and	CC
cord-015021-pol2qm74	2284	7	mean	mean	VB
cord-015021-pol2qm74	2284	8	PA	PA	NNP
cord-015021-pol2qm74	2284	9	pressure	pressure	NN
cord-015021-pol2qm74	2284	10	(	(	-LRB-
cord-015021-pol2qm74	2284	11	MPAP	MPAP	NNP
cord-015021-pol2qm74	2284	12	Gerlach	Gerlach	NNP
cord-015021-pol2qm74	2284	13	H	H	NNP
cord-015021-pol2qm74	2284	14	,	,	,
cord-015021-pol2qm74	2284	15	Gerlach	Gerlach	NNP
cord-015021-pol2qm74	2284	16	M	M	NNP
cord-015021-pol2qm74	2284	17	,	,	,
cord-015021-pol2qm74	2284	18	Clauss	Clauss	NNP
cord-015021-pol2qm74	2284	19	M	M	NNP
cord-015021-pol2qm74	2284	20	,	,	,
cord-015021-pol2qm74	2284	21	Falke	Falke	NNP
cord-015021-pol2qm74	2284	22	KJ	KJ	NNP
cord-015021-pol2qm74	2284	23	Renal	renal	JJ
cord-015021-pol2qm74	2284	24	hypoxia	hypoxia	NN
cord-015021-pol2qm74	2284	25	and/or	and/or	CC
cord-015021-pol2qm74	2284	26	ischemia	ischemia	NN
cord-015021-pol2qm74	2284	27	initiates	initiate	VBZ
cord-015021-pol2qm74	2284	28	the	the	DT
cord-015021-pol2qm74	2284	29	development	development	NN
cord-015021-pol2qm74	2284	30	of	of	IN
cord-015021-pol2qm74	2284	31	a	a	DT
cord-015021-pol2qm74	2284	32	deteriorated	deteriorate	VBN
cord-015021-pol2qm74	2284	33	medullary	medullary	JJ
cord-015021-pol2qm74	2284	34	perfusion	perfusion	NN
cord-015021-pol2qm74	2284	35	based	base	VBN
cord-015021-pol2qm74	2284	36	on	on	IN
cord-015021-pol2qm74	2284	37	fibrin	fibrin	NN
cord-015021-pol2qm74	2284	38	deposition	deposition	NN
cord-015021-pol2qm74	2284	39	in	in	IN
cord-015021-pol2qm74	2284	40	the	the	DT
cord-015021-pol2qm74	2284	41	peritubular	peritubular	JJ
cord-015021-pol2qm74	2284	42	capillaries	capillary	NNS
cord-015021-pol2qm74	2284	43	,	,	,
cord-015021-pol2qm74	2284	44	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	2284	45	,	,	,
cord-015021-pol2qm74	2284	46	and	and	CC
cord-015021-pol2qm74	2284	47	perivascular	perivascular	JJ
cord-015021-pol2qm74	2284	48	edema	edema	NN
cord-015021-pol2qm74	2284	49	,	,	,
cord-015021-pol2qm74	2284	50	which	which	WDT
cord-015021-pol2qm74	2284	51	is	be	VBZ
cord-015021-pol2qm74	2284	52	followed	follow	VBN
cord-015021-pol2qm74	2284	53	by	by	IN
cord-015021-pol2qm74	2284	54	a	a	DT
cord-015021-pol2qm74	2284	55	swelling	swelling	NN
cord-015021-pol2qm74	2284	56	of	of	IN
cord-015021-pol2qm74	2284	57	the	the	DT
cord-015021-pol2qm74	2284	58	tubular	tubular	JJ
cord-015021-pol2qm74	2284	59	epithelial	epithelial	JJ
cord-015021-pol2qm74	2284	60	ceils	ceil	NNS
cord-015021-pol2qm74	2284	61	,	,	,
cord-015021-pol2qm74	2284	62	intraluminal	intraluminal	JJ
cord-015021-pol2qm74	2284	63	tubular	tubular	JJ
cord-015021-pol2qm74	2284	64	obstruction	obstruction	NN
cord-015021-pol2qm74	2284	65	,	,	,
cord-015021-pol2qm74	2284	66	and	and	CC
cord-015021-pol2qm74	2284	67	a	a	DT
cord-015021-pol2qm74	2284	68	backleak	backleak	NN
cord-015021-pol2qm74	2284	69	of	of	IN
cord-015021-pol2qm74	2284	70	fluid	fluid	NN
cord-015021-pol2qm74	2284	71	through	through	IN
cord-015021-pol2qm74	2284	72	the	the	DT
cord-015021-pol2qm74	2284	73	injured	injure	VBN
cord-015021-pol2qm74	2284	74	tubules	tubule	NNS
cord-015021-pol2qm74	2284	75	into	into	IN
cord-015021-pol2qm74	2284	76	the	the	DT
cord-015021-pol2qm74	2284	77	renal	renal	JJ
cord-015021-pol2qm74	2284	78	interstitium	interstitium	NN
cord-015021-pol2qm74	2284	79	,	,	,
cord-015021-pol2qm74	2284	80	finally	finally	RB
cord-015021-pol2qm74	2284	81	leading	lead	VBG
cord-015021-pol2qm74	2284	82	to	to	IN
cord-015021-pol2qm74	2284	83	an	an	DT
cord-015021-pol2qm74	2284	84	acute	acute	JJ
cord-015021-pol2qm74	2284	85	tubular	tubular	JJ
cord-015021-pol2qm74	2284	86	necrosis	necrosis	NN
cord-015021-pol2qm74	2284	87	(	(	-LRB-
cord-015021-pol2qm74	2284	88	ATN	ATN	NNP
cord-015021-pol2qm74	2284	89	)	)	-RRB-
cord-015021-pol2qm74	2284	90	[	[	-LRB-
cord-015021-pol2qm74	2284	91	1	1	CD
cord-015021-pol2qm74	2284	92	]	]	-RRB-
cord-015021-pol2qm74	2284	93	,	,	,
cord-015021-pol2qm74	2284	94	clinically	clinically	RB
cord-015021-pol2qm74	2284	95	diagnosed	diagnose	VBN
cord-015021-pol2qm74	2284	96	as	as	IN
cord-015021-pol2qm74	2284	97	acute	acute	JJ
cord-015021-pol2qm74	2284	98	renal	renal	JJ
cord-015021-pol2qm74	2284	99	failure	failure	NN
cord-015021-pol2qm74	2284	100	(	(	-LRB-
cord-015021-pol2qm74	2284	101	ARF	ARF	NNP
cord-015021-pol2qm74	2284	102	)	)	-RRB-
cord-015021-pol2qm74	2284	103	.	.	.
cord-015021-pol2qm74	2285	1	One	one	CD
cord-015021-pol2qm74	2285	2	important	important	JJ
cord-015021-pol2qm74	2285	3	pathway	pathway	NN
cord-015021-pol2qm74	2285	4	for	for	IN
cord-015021-pol2qm74	2285	5	induction	induction	NN
cord-015021-pol2qm74	2285	6	of	of	IN
cord-015021-pol2qm74	2285	7	enhanced	enhanced	JJ
cord-015021-pol2qm74	2285	8	vascular	vascular	JJ
cord-015021-pol2qm74	2285	9	procoagulant	procoagulant	JJ
cord-015021-pol2qm74	2285	10	activity	activity	NN
cord-015021-pol2qm74	2285	11	and	and	CC
cord-015021-pol2qm74	2285	12	permeability	permeability	NN
cord-015021-pol2qm74	2285	13	is	be	VBZ
cord-015021-pol2qm74	2285	14	based	base	VBN
cord-015021-pol2qm74	2285	15	on	on	IN
cord-015021-pol2qm74	2285	16	the	the	DT
cord-015021-pol2qm74	2285	17	synthesis	synthesis	NN
cord-015021-pol2qm74	2285	18	and	and	CC
cord-015021-pol2qm74	2285	19	expression	expression	NN
cord-015021-pol2qm74	2285	20	of	of	IN
cord-015021-pol2qm74	2285	21	macrophage	macrophage	NN
cord-015021-pol2qm74	2285	22	-	-	HYPH
cord-015021-pol2qm74	2285	23	derived	derive	VBN
cord-015021-pol2qm74	2285	24	cytokines	cytokine	NNS
cord-015021-pol2qm74	2285	25	,	,	,
cord-015021-pol2qm74	2285	26	which	which	WDT
cord-015021-pol2qm74	2285	27	bind	bind	VBP
cord-015021-pol2qm74	2285	28	to	to	IN
cord-015021-pol2qm74	2285	29	specific	specific	JJ
cord-015021-pol2qm74	2285	30	endothelial	endothelial	JJ
cord-015021-pol2qm74	2285	31	cell	cell	NN
cord-015021-pol2qm74	2285	32	surface	surface	NN
cord-015021-pol2qm74	2285	33	receptors	receptor	NNS
cord-015021-pol2qm74	2285	34	.	.	.
cord-015021-pol2qm74	2286	1	We	-PRON-	PRP
cord-015021-pol2qm74	2286	2	recently	recently	RB
cord-015021-pol2qm74	2286	3	described	describe	VBD
cord-015021-pol2qm74	2286	4	the	the	DT
cord-015021-pol2qm74	2286	5	identification	identification	NN
cord-015021-pol2qm74	2286	6	and	and	CC
cord-015021-pol2qm74	2286	7	purification	purification	NN
cord-015021-pol2qm74	2286	8	.of	.of	.
cord-015021-pol2qm74	2287	1	a	a	DT
cord-015021-pol2qm74	2287	2	new	new	JJ
cord-015021-pol2qm74	2287	3	55,000	55,000	CD
cord-015021-pol2qm74	2287	4	Dalton	Dalton	NNP
cord-015021-pol2qm74	2287	5	polypeptide	polypeptide	NN
cord-015021-pol2qm74	2287	6	,	,	,
cord-015021-pol2qm74	2287	7	which	which	WDT
cord-015021-pol2qm74	2287	8	is	be	VBZ
cord-015021-pol2qm74	2287	9	synthesized	synthesize	VBN
cord-015021-pol2qm74	2287	10	and	and	CC
cord-015021-pol2qm74	2287	11	expressed	express	VBN
cord-015021-pol2qm74	2287	12	by	by	IN
cord-015021-pol2qm74	2287	13	murine	murine	JJ
cord-015021-pol2qm74	2287	14	macrophages	macrophage	NNS
cord-015021-pol2qm74	2287	15	after	after	IN
cord-015021-pol2qm74	2287	16	stimulation	stimulation	NN
cord-015021-pol2qm74	2287	17	with	with	IN
cord-015021-pol2qm74	2287	18	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	2287	19	,	,	,
cord-015021-pol2qm74	2287	20	and	and	CC
cord-015021-pol2qm74	2287	21	exerts	exert	VBZ
cord-015021-pol2qm74	2287	22	procoagulant	procoagulant	JJ
cord-015021-pol2qm74	2287	23	activity	activity	NN
cord-015021-pol2qm74	2287	24	on	on	IN
cord-015021-pol2qm74	2287	25	cultured	cultured	JJ
cord-015021-pol2qm74	2287	26	endothelial	endothelial	JJ
cord-015021-pol2qm74	2287	27	cells	cell	NNS
cord-015021-pol2qm74	2287	28	[	[	-LRB-
cord-015021-pol2qm74	2287	29	2	2	CD
cord-015021-pol2qm74	2287	30	]	]	-RRB-
cord-015021-pol2qm74	2287	31	.	.	.
cord-015021-pol2qm74	2288	1	In	in	IN
cord-015021-pol2qm74	2288	2	the	the	DT
cord-015021-pol2qm74	2288	3	presented	present	VBN
cord-015021-pol2qm74	2288	4	study	study	NN
cord-015021-pol2qm74	2288	5	,	,	,
cord-015021-pol2qm74	2288	6	we	-PRON-	PRP
cord-015021-pol2qm74	2288	7	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2288	8	that	that	IN
cord-015021-pol2qm74	2288	9	the	the	DT
cord-015021-pol2qm74	2288	10	new	new	JJ
cord-015021-pol2qm74	2288	11	polypeptid	polypeptid	NN
cord-015021-pol2qm74	2288	12	is	be	VBZ
cord-015021-pol2qm74	2288	13	also	also	RB
cord-015021-pol2qm74	2288	14	synthesized	synthesize	VBN
cord-015021-pol2qm74	2288	15	by	by	IN
cord-015021-pol2qm74	2288	16	macrophages	macrophage	NNS
cord-015021-pol2qm74	2288	17	under	under	IN
cord-015021-pol2qm74	2288	18	hypoxic	hypoxic	JJ
cord-015021-pol2qm74	2288	19	conditions	condition	NNS
cord-015021-pol2qm74	2288	20	.	.	.
cord-015021-pol2qm74	2289	1	The	the	DT
cord-015021-pol2qm74	2289	2	protein	protein	NN
cord-015021-pol2qm74	2289	3	binds	bind	VBZ
cord-015021-pol2qm74	2289	4	to	to	IN
cord-015021-pol2qm74	2289	5	specific	specific	JJ
cord-015021-pol2qm74	2289	6	receptors	receptor	NNS
cord-015021-pol2qm74	2289	7	,	,	,
cord-015021-pol2qm74	2289	8	which	which	WDT
cord-015021-pol2qm74	2289	9	are	be	VBP
cord-015021-pol2qm74	2289	10	expressed	express	VBN
cord-015021-pol2qm74	2289	11	by	by	IN
cord-015021-pol2qm74	2289	12	endothelial	endothelial	JJ
cord-015021-pol2qm74	2289	13	cells	cell	NNS
cord-015021-pol2qm74	2289	14	dependent	dependent	JJ
cord-015021-pol2qm74	2289	15	on	on	IN
cord-015021-pol2qm74	2289	16	the	the	DT
cord-015021-pol2qm74	2289	17	environmental	environmental	JJ
cord-015021-pol2qm74	2289	18	oxygen	oxygen	NN
cord-015021-pol2qm74	2289	19	tension	tension	NN
cord-015021-pol2qm74	2289	20	.	.	.
cord-015021-pol2qm74	2290	1	Animal	animal	NN
cord-015021-pol2qm74	2290	2	studies	study	NNS
cord-015021-pol2qm74	2290	3	were	be	VBD
cord-015021-pol2qm74	2290	4	performed	perform	VBN
cord-015021-pol2qm74	2290	5	after	after	IN
cord-015021-pol2qm74	2290	6	approval	approval	NN
cord-015021-pol2qm74	2290	7	by	by	IN
cord-015021-pol2qm74	2290	8	the	the	DT
cord-015021-pol2qm74	2290	9	local	local	JJ
cord-015021-pol2qm74	2290	10	committee	committee	NN
cord-015021-pol2qm74	2290	11	for	for	IN
cord-015021-pol2qm74	2290	12	animal	animal	NNP
cord-015021-pol2qm74	2290	13	safety	safety	NN
cord-015021-pol2qm74	2290	14	;	;	:
cord-015021-pol2qm74	2290	15	the	the	DT
cord-015021-pol2qm74	2290	16	animals	animal	NNS
cord-015021-pol2qm74	2290	17	were	be	VBD
cord-015021-pol2qm74	2290	18	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	2290	19	,	,	,
cord-015021-pol2qm74	2290	20	treated	treat	VBN
cord-015021-pol2qm74	2290	21	and	and	CC
cord-015021-pol2qm74	2290	22	supervised	supervise	VBN
cord-015021-pol2qm74	2290	23	in	in	IN
cord-015021-pol2qm74	2290	24	accordance	accordance	NN
cord-015021-pol2qm74	2290	25	with	with	IN
cord-015021-pol2qm74	2290	26	the	the	DT
cord-015021-pol2qm74	2290	27	guidelines	guideline	NNS
cord-015021-pol2qm74	2290	28	of	of	IN
cord-015021-pol2qm74	2290	29	this	this	DT
cord-015021-pol2qm74	2290	30	committee	committee	NN
cord-015021-pol2qm74	2290	31	.	.	.
cord-015021-pol2qm74	2291	1	In	in	IN
cord-015021-pol2qm74	2291	2	contrast	contrast	NN
cord-015021-pol2qm74	2291	3	to	to	IN
cord-015021-pol2qm74	2291	4	other	other	JJ
cord-015021-pol2qm74	2291	5	authors	author	NNS
cord-015021-pol2qm74	2291	6	,	,	,
cord-015021-pol2qm74	2291	7	who	who	WP
cord-015021-pol2qm74	2291	8	performed	perform	VBD
cord-015021-pol2qm74	2291	9	long	long	JJ
cord-015021-pol2qm74	2291	10	-	-	HYPH
cord-015021-pol2qm74	2291	11	term	term	NN
cord-015021-pol2qm74	2291	12	hypoxia	hypoxia	NN
cord-015021-pol2qm74	2291	13	experiments	experiment	NNS
cord-015021-pol2qm74	2291	14	in	in	IN
cord-015021-pol2qm74	2291	15	awake	awake	JJ
cord-015021-pol2qm74	2291	16	animals	animal	NNS
cord-015021-pol2qm74	2291	17	,	,	,
cord-015021-pol2qm74	2291	18	we	-PRON-	PRP
cord-015021-pol2qm74	2291	19	preferred	prefer	VBD
cord-015021-pol2qm74	2291	20	to	to	TO
cord-015021-pol2qm74	2291	21	implement	implement	VB
cord-015021-pol2qm74	2291	22	the	the	DT
cord-015021-pol2qm74	2291	23	studies	study	NNS
cord-015021-pol2qm74	2291	24	under	under	IN
cord-015021-pol2qm74	2291	25	anesthesia	anesthesia	NN
cord-015021-pol2qm74	2291	26	for	for	IN
cord-015021-pol2qm74	2291	27	ethical	ethical	JJ
cord-015021-pol2qm74	2291	28	reasons	reason	NNS
cord-015021-pol2qm74	2291	29	,	,	,
cord-015021-pol2qm74	2291	30	although	although	IN
cord-015021-pol2qm74	2291	31	regulatory	regulatory	JJ
cord-015021-pol2qm74	2291	32	functions	function	NNS
cord-015021-pol2qm74	2291	33	for	for	IN
cord-015021-pol2qm74	2291	34	ventilation	ventilation	NN
cord-015021-pol2qm74	2291	35	might	may	MD
cord-015021-pol2qm74	2291	36	be	be	VB
cord-015021-pol2qm74	2291	37	influenced	influence	VBN
cord-015021-pol2qm74	2291	38	.	.	.
cord-015021-pol2qm74	2292	1	Animal	animal	NN
cord-015021-pol2qm74	2292	2	studies	study	NNS
cord-015021-pol2qm74	2292	3	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	2292	4	that	that	IN
cord-015021-pol2qm74	2292	5	the	the	DT
cord-015021-pol2qm74	2292	6	intravenous	intravenous	JJ
cord-015021-pol2qm74	2292	7	injection	injection	NN
cord-015021-pol2qm74	2292	8	of	of	IN
cord-015021-pol2qm74	2292	9	the	the	DT
cord-015021-pol2qm74	2292	10	polypeptide	polypeptide	NN
cord-015021-pol2qm74	2292	11	initiates	initiate	VBZ
cord-015021-pol2qm74	2292	12	fibrin	fibrin	NN
cord-015021-pol2qm74	2292	13	formation	formation	NN
cord-015021-pol2qm74	2292	14	in	in	IN
cord-015021-pol2qm74	2292	15	the	the	DT
cord-015021-pol2qm74	2292	16	peritubular	peritubular	JJ
cord-015021-pol2qm74	2292	17	vessels	vessel	NNS
cord-015021-pol2qm74	2292	18	.	.	.
cord-015021-pol2qm74	2293	1	Keeping	keep	VBG
cord-015021-pol2qm74	2293	2	the	the	DT
cord-015021-pol2qm74	2293	3	animals	animal	NNS
cord-015021-pol2qm74	2293	4	under	under	IN
cord-015021-pol2qm74	2293	5	hypoxic	hypoxic	JJ
cord-015021-pol2qm74	2293	6	conditions	condition	NNS
cord-015021-pol2qm74	2293	7	induces	induce	VBZ
cord-015021-pol2qm74	2293	8	similar	similar	JJ
cord-015021-pol2qm74	2293	9	effects	effect	NNS
cord-015021-pol2qm74	2293	10	,	,	,
cord-015021-pol2qm74	2293	11	which	which	WDT
cord-015021-pol2qm74	2293	12	are	be	VBP
cord-015021-pol2qm74	2293	13	reduced	reduce	VBN
cord-015021-pol2qm74	2293	14	by	by	IN
cord-015021-pol2qm74	2293	15	a	a	DT
cord-015021-pol2qm74	2293	16	rabbit	rabbit	NN
cord-015021-pol2qm74	2293	17	-	-	HYPH
cord-015021-pol2qm74	2293	18	antiserum	antiserum	NN
cord-015021-pol2qm74	2293	19	against	against	IN
cord-015021-pol2qm74	2293	20	the	the	DT
cord-015021-pol2qm74	2293	21	new	new	JJ
cord-015021-pol2qm74	2293	22	protein	protein	NN
cord-015021-pol2qm74	2293	23	.	.	.
cord-015021-pol2qm74	2294	1	In	in	IN
cord-015021-pol2qm74	2294	2	conclusion	conclusion	NN
cord-015021-pol2qm74	2294	3	,	,	,
cord-015021-pol2qm74	2294	4	the	the	DT
cord-015021-pol2qm74	2294	5	new	new	JJ
cord-015021-pol2qm74	2294	6	polypeptide	polypeptide	NN
cord-015021-pol2qm74	2294	7	obviously	obviously	RB
cord-015021-pol2qm74	2294	8	contributes	contribute	VBZ
cord-015021-pol2qm74	2294	9	to	to	IN
cord-015021-pol2qm74	2294	10	the	the	DT
cord-015021-pol2qm74	2294	11	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	2294	12	of	of	IN
cord-015021-pol2qm74	2294	13	acute	acute	JJ
cord-015021-pol2qm74	2294	14	renal	renal	JJ
cord-015021-pol2qm74	2294	15	failure	failure	NN
cord-015021-pol2qm74	2294	16	by	by	IN
cord-015021-pol2qm74	2294	17	tubular	tubular	JJ
cord-015021-pol2qm74	2294	18	necrosis	necrosis	NN
cord-015021-pol2qm74	2294	19	during	during	IN
cord-015021-pol2qm74	2294	20	and	and	CC
cord-015021-pol2qm74	2294	21	after	after	IN
cord-015021-pol2qm74	2294	22	hypoxic	hypoxic	JJ
cord-015021-pol2qm74	2294	23	events	event	NNS
cord-015021-pol2qm74	2294	24	.	.	.
cord-015021-pol2qm74	2295	1	The	the	DT
cord-015021-pol2qm74	2295	2	use	use	NN
cord-015021-pol2qm74	2295	3	of	of	IN
cord-015021-pol2qm74	2295	4	verapamil	verapamil	NN
cord-015021-pol2qm74	2295	5	as	as	IN
cord-015021-pol2qm74	2295	6	cardioprotective	cardioprotective	JJ
cord-015021-pol2qm74	2295	7	agents	agent	NNS
cord-015021-pol2qm74	2295	8	for	for	IN
cord-015021-pol2qm74	2295	9	management	management	NN
cord-015021-pol2qm74	2295	10	of	of	IN
cord-015021-pol2qm74	2295	11	patients	patient	NNS
cord-015021-pol2qm74	2295	12	with	with	IN
cord-015021-pol2qm74	2295	13	acute	acute	JJ
cord-015021-pol2qm74	2295	14	ischemic	ischemic	JJ
cord-015021-pol2qm74	2295	15	/	/	SYM
cord-015021-pol2qm74	2295	16	reperfused	reperfused	JJ
cord-015021-pol2qm74	2295	17	heart	heart	NN
cord-015021-pol2qm74	2295	18	is	be	VBZ
cord-015021-pol2qm74	2295	19	based	base	VBN
cord-015021-pol2qm74	2295	20	on	on	IN
cord-015021-pol2qm74	2295	21	the	the	DT
cord-015021-pol2qm74	2295	22	assumption	assumption	NN
cord-015021-pol2qm74	2295	23	that	that	IN
cord-015021-pol2qm74	2295	24	the	the	DT
cord-015021-pol2qm74	2295	25	increased	increase	VBN
cord-015021-pol2qm74	2295	26	intracellular	intracellular	JJ
cord-015021-pol2qm74	2295	27	Ca+	Ca+	NNP
cord-015021-pol2qm74	2295	28	level	level	NN
cord-015021-pol2qm74	2295	29	is	be	VBZ
cord-015021-pol2qm74	2295	30	a	a	DT
cord-015021-pol2qm74	2295	31	key	key	JJ
cord-015021-pol2qm74	2295	32	factor	factor	NN
cord-015021-pol2qm74	2295	33	in	in	IN
cord-015021-pol2qm74	2295	34	causing	cause	VBG
cord-015021-pol2qm74	2295	35	cell	cell	NN
cord-015021-pol2qm74	2295	36	death	death	NN
cord-015021-pol2qm74	2295	37	.	.	.
cord-015021-pol2qm74	2296	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2296	2	in	in	FW
cord-015021-pol2qm74	2296	3	vitro	vitro	FW
cord-015021-pol2qm74	2296	4	study	study	NN
cord-015021-pol2qm74	2296	5	was	be	VBD
cord-015021-pol2qm74	2296	6	designed	design	VBN
cord-015021-pol2qm74	2296	7	to	to	TO
cord-015021-pol2qm74	2296	8	focus	focus	VB
cord-015021-pol2qm74	2296	9	on	on	IN
cord-015021-pol2qm74	2296	10	effects	effect	NNS
cord-015021-pol2qm74	2296	11	of	of	IN
cord-015021-pol2qm74	2296	12	verapamil	verapamil	NN
cord-015021-pol2qm74	2296	13	on	on	IN
cord-015021-pol2qm74	2296	14	the	the	DT
cord-015021-pol2qm74	2296	15	metabolic	metabolic	JJ
cord-015021-pol2qm74	2296	16	potential	potential	NN
cord-015021-pol2qm74	2296	17	of	of	IN
cord-015021-pol2qm74	2296	18	cardiac	cardiac	JJ
cord-015021-pol2qm74	2296	19	slices	slice	NNS
cord-015021-pol2qm74	2296	20	after	after	IN
cord-015021-pol2qm74	2296	21	reversible	reversible	JJ
cord-015021-pol2qm74	2296	22	ischemia	ischemia	NN
cord-015021-pol2qm74	2296	23	in	in	IN
cord-015021-pol2qm74	2296	24	rats	rat	NNS
cord-015021-pol2qm74	2296	25	.	.	.
cord-015021-pol2qm74	2297	1	The	the	DT
cord-015021-pol2qm74	2297	2	material	material	NN
cord-015021-pol2qm74	2297	3	consisted	consist	VBD
cord-015021-pol2qm74	2297	4	of	of	IN
cord-015021-pol2qm74	2297	5	two	two	CD
cord-015021-pol2qm74	2297	6	main	main	JJ
cord-015021-pol2qm74	2297	7	groups	group	NNS
cord-015021-pol2qm74	2297	8	:	:	:
cord-015021-pol2qm74	2297	9	group	group	NN
cord-015021-pol2qm74	2297	10	A	A	NNP
cord-015021-pol2qm74	2297	11	(	(	-LRB-
cord-015021-pol2qm74	2297	12	non	non	FW
cord-015021-pol2qm74	2297	13	ischemia	ischemia	NN
cord-015021-pol2qm74	2297	14	/	/	SYM
cord-015021-pol2qm74	2297	15	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2297	16	group	group	NN
cord-015021-pol2qm74	2297	17	)	)	-RRB-
cord-015021-pol2qm74	2297	18	and	and	CC
cord-015021-pol2qm74	2297	19	group	group	NN
cord-015021-pol2qm74	2297	20	B	B	NNP
cord-015021-pol2qm74	2297	21	(	(	-LRB-
cord-015021-pol2qm74	2297	22	ischemia	ischemia	NN
cord-015021-pol2qm74	2297	23	/	/	SYM
cord-015021-pol2qm74	2297	24	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2297	25	group	group	NN
cord-015021-pol2qm74	2297	26	)	)	-RRB-
cord-015021-pol2qm74	2297	27	,	,	,
cord-015021-pol2qm74	2297	28	Each	each	DT
cord-015021-pol2qm74	2297	29	is	be	VBZ
cord-015021-pol2qm74	2297	30	subdivided	subdivide	VBN
cord-015021-pol2qm74	2297	31	into	into	IN
cord-015021-pol2qm74	2297	32	two	two	CD
cord-015021-pol2qm74	2297	33	subgroups	subgroup	NNS
cord-015021-pol2qm74	2297	34	(	(	-LRB-
cord-015021-pol2qm74	2297	35	a	a	NN
cord-015021-pol2qm74	2297	36	and	and	CC
cord-015021-pol2qm74	2297	37	b	b	LS
cord-015021-pol2qm74	2297	38	)	)	-RRB-
cord-015021-pol2qm74	2297	39	.	.	.
cord-015021-pol2qm74	2298	1	Each	each	DT
cord-015021-pol2qm74	2298	2	subgroup	subgroup	NN
cord-015021-pol2qm74	2298	3	included	include	VBD
cord-015021-pol2qm74	2298	4	10	10	CD
cord-015021-pol2qm74	2298	5	rat	rat	NN
cord-015021-pol2qm74	2298	6	hearts	heart	NNS
cord-015021-pol2qm74	2298	7	.	.	.
cord-015021-pol2qm74	2299	1	Group	Group	NNP
cord-015021-pol2qm74	2299	2	Aa	Aa	NNP
cord-015021-pol2qm74	2299	3	is	be	VBZ
cord-015021-pol2qm74	2299	4	the	the	DT
cord-015021-pol2qm74	2299	5	control	control	NN
cord-015021-pol2qm74	2299	6	group	group	NN
cord-015021-pol2qm74	2299	7	,	,	,
cord-015021-pol2qm74	2299	8	Group	Group	NNP
cord-015021-pol2qm74	2299	9	Ab	Ab	NNP
cord-015021-pol2qm74	2300	1	is	be	VBZ
cord-015021-pol2qm74	2300	2	verapami	verapami	NNP
cord-015021-pol2qm74	2300	3	]	]	-RRB-
cord-015021-pol2qm74	2300	4	added	add	VBN
cord-015021-pol2qm74	2300	5	group	group	NN
cord-015021-pol2qm74	2300	6	.	.	.
cord-015021-pol2qm74	2301	1	Group	Group	NNP
cord-015021-pol2qm74	2301	2	Ba	Ba	NNP
cord-015021-pol2qm74	2301	3	is	be	VBZ
cord-015021-pol2qm74	2301	4	ischemia	ischemia	NN
cord-015021-pol2qm74	2301	5	group	group	NN
cord-015021-pol2qm74	2301	6	without	without	IN
cord-015021-pol2qm74	2301	7	verapamil	verapamil	NN
cord-015021-pol2qm74	2301	8	.	.	.
cord-015021-pol2qm74	2302	1	Group	Group	NNP
cord-015021-pol2qm74	2302	2	Bb	Bb	NNP
cord-015021-pol2qm74	2302	3	is	be	VBZ
cord-015021-pol2qm74	2302	4	verapamil	verapamil	NN
cord-015021-pol2qm74	2302	5	added	add	VBN
cord-015021-pol2qm74	2302	6	group	group	NN
cord-015021-pol2qm74	2302	7	.	.	.
cord-015021-pol2qm74	2303	1	Ischemic	ischemic	JJ
cord-015021-pol2qm74	2303	2	cardiac	cardiac	JJ
cord-015021-pol2qm74	2303	3	slices	slice	NNS
cord-015021-pol2qm74	2303	4	were	be	VBD
cord-015021-pol2qm74	2303	5	obtained	obtain	VBN
cord-015021-pol2qm74	2303	6	from	from	IN
cord-015021-pol2qm74	2303	7	rats	rat	NNS
cord-015021-pol2qm74	2303	8	subjected	subject	VBN
cord-015021-pol2qm74	2303	9	to	to	IN
cord-015021-pol2qm74	2303	10	15	15	CD
cord-015021-pol2qm74	2303	11	min	min	NN
cord-015021-pol2qm74	2303	12	.	.	.
cord-015021-pol2qm74	2304	1	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	2304	2	to	to	TO
cord-015021-pol2qm74	2304	3	induce	induce	VB
cord-015021-pol2qm74	2304	4	reversible	reversible	JJ
cord-015021-pol2qm74	2304	5	global	global	JJ
cord-015021-pol2qm74	2304	6	ischemia	ischemia	NN
cord-015021-pol2qm74	2304	7	.	.	.
cord-015021-pol2qm74	2305	1	Both	both	DT
cord-015021-pol2qm74	2305	2	nonischemic	nonischemic	JJ
cord-015021-pol2qm74	2305	3	and	and	CC
cord-015021-pol2qm74	2305	4	ischemic	ischemic	JJ
cord-015021-pol2qm74	2305	5	cardiac	cardiac	JJ
cord-015021-pol2qm74	2305	6	slices	slice	NNS
cord-015021-pol2qm74	2305	7	were	be	VBD
cord-015021-pol2qm74	2305	8	placed	place	VBN
cord-015021-pol2qm74	2305	9	in	in	IN
cord-015021-pol2qm74	2305	10	well	well	RB
cord-015021-pol2qm74	2305	11	oxygenated	oxygenated	JJ
cord-015021-pol2qm74	2305	12	krebs	krebs	NNP
cord-015021-pol2qm74	2305	13	Ringer	Ringer	NNP
cord-015021-pol2qm74	2305	14	phosphate	phosphate	NN
cord-015021-pol2qm74	2305	15	buffer	buffer	NN
cord-015021-pol2qm74	2305	16	containing	contain	VBG
cord-015021-pol2qm74	2305	17	150	150	CD
cord-015021-pol2qm74	2305	18	mg%	mg%	CD
cord-015021-pol2qm74	2305	19	glucose	glucose	NN
cord-015021-pol2qm74	2305	20	&	&	CC
cord-015021-pol2qm74	2305	21	5	5	CD
cord-015021-pol2qm74	2305	22	gm%	gm%	CD
cord-015021-pol2qm74	2305	23	bovine	bovine	JJ
cord-015021-pol2qm74	2305	24	albumin	albumin	NN
cord-015021-pol2qm74	2305	25	and	and	CC
cord-015021-pol2qm74	2305	26	incubated	incubate	VBN
cord-015021-pol2qm74	2305	27	in	in	IN
cord-015021-pol2qm74	2305	28	Dubnoff	Dubnoff	NNP
cord-015021-pol2qm74	2305	29	shaking	shake	VBG
cord-015021-pol2qm74	2305	30	water	water	NN
cord-015021-pol2qm74	2305	31	bath	bath	NN
cord-015021-pol2qm74	2305	32	for	for	IN
cord-015021-pol2qm74	2305	33	60min	60min	NN
cord-015021-pol2qm74	2305	34	at	at	IN
cord-015021-pol2qm74	2305	35	37	37	CD
cord-015021-pol2qm74	2305	36	°	°	NN
cord-015021-pol2qm74	2305	37	C	c	NN
cord-015021-pol2qm74	2306	1	The	the	DT
cord-015021-pol2qm74	2306	2	results	result	NNS
cord-015021-pol2qm74	2306	3	revealed	reveal	VBD
cord-015021-pol2qm74	2306	4	that	that	IN
cord-015021-pol2qm74	2306	5	there	there	EX
cord-015021-pol2qm74	2306	6	was	be	VBD
cord-015021-pol2qm74	2306	7	an	an	DT
cord-015021-pol2qm74	2306	8	enhancement	enhancement	NN
cord-015021-pol2qm74	2306	9	in	in	IN
cord-015021-pol2qm74	2306	10	release	release	NN
cord-015021-pol2qm74	2306	11	of	of	IN
cord-015021-pol2qm74	2306	12	free	free	JJ
cord-015021-pol2qm74	2306	13	fatty	fatty	JJ
cord-015021-pol2qm74	2306	14	acids	acid	NNS
cord-015021-pol2qm74	2306	15	(	(	-LRB-
cord-015021-pol2qm74	2306	16	FFA	FFA	NNP
cord-015021-pol2qm74	2306	17	)	)	-RRB-
cord-015021-pol2qm74	2306	18	(	(	-LRB-
cord-015021-pol2qm74	2306	19	240	240	CD
cord-015021-pol2qm74	2306	20	%	%	NN
cord-015021-pol2qm74	2306	21	)	)	-RRB-
cord-015021-pol2qm74	2306	22	and	and	CC
cord-015021-pol2qm74	2306	23	lactate	lactate	NN
cord-015021-pol2qm74	2306	24	(	(	-LRB-
cord-015021-pol2qm74	2306	25	163	163	CD
cord-015021-pol2qm74	2306	26	%	%	NN
cord-015021-pol2qm74	2306	27	)	)	-RRB-
cord-015021-pol2qm74	2306	28	and	and	CC
cord-015021-pol2qm74	2306	29	in	in	IN
cord-015021-pol2qm74	2306	30	glucose	glucose	NN
cord-015021-pol2qm74	2306	31	uptake	uptake	NN
cord-015021-pol2qm74	2306	32	(	(	-LRB-
cord-015021-pol2qm74	2306	33	160	160	CD
cord-015021-pol2qm74	2306	34	%	%	NN
cord-015021-pol2qm74	2306	35	)	)	-RRB-
cord-015021-pol2qm74	2306	36	in	in	IN
cord-015021-pol2qm74	2306	37	group	group	NN
cord-015021-pol2qm74	2306	38	Ba	Ba	NNP
cord-015021-pol2qm74	2306	39	as	as	IN
cord-015021-pol2qm74	2306	40	compared	compare	VBN
cord-015021-pol2qm74	2306	41	with	with	IN
cord-015021-pol2qm74	2306	42	group	group	NN
cord-015021-pol2qm74	2306	43	Aa	Aa	NNP
cord-015021-pol2qm74	2306	44	.	.	.
cord-015021-pol2qm74	2307	1	These	these	DT
cord-015021-pol2qm74	2307	2	metabolic	metabolic	JJ
cord-015021-pol2qm74	2307	3	alternations	alternation	NNS
cord-015021-pol2qm74	2307	4	produced	produce	VBN
cord-015021-pol2qm74	2307	5	by	by	IN
cord-015021-pol2qm74	2307	6	ischemic	ischemic	JJ
cord-015021-pol2qm74	2307	7	cardiac	cardiac	JJ
cord-015021-pol2qm74	2307	8	slices	slice	NNS
cord-015021-pol2qm74	2307	9	were	be	VBD
cord-015021-pol2qm74	2307	10	reversed	reverse	VBN
cord-015021-pol2qm74	2307	11	by	by	IN
cord-015021-pol2qm74	2307	12	verapamil	verapamil	NN
cord-015021-pol2qm74	2307	13	addition	addition	NN
cord-015021-pol2qm74	2307	14	(	(	-LRB-
cord-015021-pol2qm74	2307	15	200	200	CD
cord-015021-pol2qm74	2307	16	ml%	ml%	NN
cord-015021-pol2qm74	2307	17	)	)	-RRB-
cord-015021-pol2qm74	2307	18	but	but	CC
cord-015021-pol2qm74	2307	19	in	in	IN
cord-015021-pol2qm74	2307	20	group	group	NN
cord-015021-pol2qm74	2307	21	Ab	Ab	NNP
cord-015021-pol2qm74	2307	22	verpamil	verpamil	NNP
cord-015021-pol2qm74	2307	23	did	do	VBD
cord-015021-pol2qm74	2307	24	not	not	RB
cord-015021-pol2qm74	2307	25	alter	alter	VB
cord-015021-pol2qm74	2307	26	the	the	DT
cord-015021-pol2qm74	2307	27	release	release	NN
cord-015021-pol2qm74	2307	28	of	of	IN
cord-015021-pol2qm74	2307	29	FFA	FFA	NNP
cord-015021-pol2qm74	2307	30	&	&	CC
cord-015021-pol2qm74	2307	31	lactate	lactate	NN
cord-015021-pol2qm74	2307	32	from	from	IN
cord-015021-pol2qm74	2307	33	non	non	JJ
cord-015021-pol2qm74	2307	34	-	-	JJ
cord-015021-pol2qm74	2307	35	ischemic	ischemic	JJ
cord-015021-pol2qm74	2307	36	cardiac	cardiac	JJ
cord-015021-pol2qm74	2307	37	slices	slice	NNS
cord-015021-pol2qm74	2307	38	,	,	,
cord-015021-pol2qm74	2307	39	whereas	whereas	IN
cord-015021-pol2qm74	2307	40	it	-PRON-	PRP
cord-015021-pol2qm74	2307	41	inhibited	inhibit	VBD
cord-015021-pol2qm74	2307	42	glucose	glucose	NN
cord-015021-pol2qm74	2307	43	uptake	uptake	NN
cord-015021-pol2qm74	2307	44	from	from	IN
cord-015021-pol2qm74	2307	45	these	these	DT
cord-015021-pol2qm74	2307	46	slices	slice	NNS
cord-015021-pol2qm74	2307	47	by	by	IN
cord-015021-pol2qm74	2307	48	67	67	CD
cord-015021-pol2qm74	2307	49	%	%	NN
cord-015021-pol2qm74	2307	50	.	.	.
cord-015021-pol2qm74	2308	1	The	the	DT
cord-015021-pol2qm74	2308	2	improvement	improvement	NN
cord-015021-pol2qm74	2308	3	of	of	IN
cord-015021-pol2qm74	2308	4	the	the	DT
cord-015021-pol2qm74	2308	5	metabolic	metabolic	JJ
cord-015021-pol2qm74	2308	6	intervention	intervention	NN
cord-015021-pol2qm74	2308	7	of	of	IN
cord-015021-pol2qm74	2308	8	ischemic	ischemic	JJ
cord-015021-pol2qm74	2308	9	myocardium	myocardium	NN
cord-015021-pol2qm74	2308	10	indicates	indicate	VBZ
cord-015021-pol2qm74	2308	11	that	that	IN
cord-015021-pol2qm74	2308	12	verapamil	verapamil	NN
cord-015021-pol2qm74	2308	13	may	may	MD
cord-015021-pol2qm74	2308	14	be	be	VB
cord-015021-pol2qm74	2308	15	of	of	IN
cord-015021-pol2qm74	2308	16	importance	importance	NN
cord-015021-pol2qm74	2308	17	in	in	IN
cord-015021-pol2qm74	2308	18	reducing	reduce	VBG
cord-015021-pol2qm74	2308	19	the	the	DT
cord-015021-pol2qm74	2308	20	extent	extent	NN
cord-015021-pol2qm74	2308	21	and	and	CC
cord-015021-pol2qm74	2308	22	severity	severity	NN
cord-015021-pol2qm74	2308	23	of	of	IN
cord-015021-pol2qm74	2308	24	acute	acute	JJ
cord-015021-pol2qm74	2308	25	myocardial	myocardial	JJ
cord-015021-pol2qm74	2308	26	ischemic	ischemic	JJ
cord-015021-pol2qm74	2308	27	injury	injury	NN
cord-015021-pol2qm74	2308	28	in	in	IN
cord-015021-pol2qm74	2308	29	acute	acute	JJ
cord-015021-pol2qm74	2308	30	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	2308	31	.	.	.
cord-015021-pol2qm74	2309	1	Severe	severe	JJ
cord-015021-pol2qm74	2309	2	endothelial	endothelial	JJ
cord-015021-pol2qm74	2309	3	dysfunction	dysfunction	NN
cord-015021-pol2qm74	2309	4	occurs	occur	VBZ
cord-015021-pol2qm74	2309	5	following	follow	VBG
cord-015021-pol2qm74	2309	6	injury	injury	NN
cord-015021-pol2qm74	2309	7	to	to	IN
cord-015021-pol2qm74	2309	8	carotid	carotid	JJ
cord-015021-pol2qm74	2309	9	arteries	artery	NNS
cord-015021-pol2qm74	2309	10	which	which	WDT
cord-015021-pol2qm74	2309	11	is	be	VBZ
cord-015021-pol2qm74	2309	12	characterized	characterize	VBN
cord-015021-pol2qm74	2309	13	by	by	IN
cord-015021-pol2qm74	2309	14	a	a	DT
cord-015021-pol2qm74	2309	15	decreased	decrease	VBN
cord-015021-pol2qm74	2309	16	ability	ability	NN
cord-015021-pol2qm74	2309	17	of	of	IN
cord-015021-pol2qm74	2309	18	these	these	DT
cord-015021-pol2qm74	2309	19	arteries	artery	NNS
cord-015021-pol2qm74	2309	20	to	to	TO
cord-015021-pol2qm74	2309	21	dilate	dilate	VB
cord-015021-pol2qm74	2309	22	when	when	WRB
cord-015021-pol2qm74	2309	23	challenged	challenge	VBN
cord-015021-pol2qm74	2309	24	with	with	IN
cord-015021-pol2qm74	2309	25	ACh	ACh	NNP
cord-015021-pol2qm74	2309	26	or	or	CC
cord-015021-pol2qm74	2309	27	A23187	A23187	NNP
cord-015021-pol2qm74	2309	28	,	,	,
cord-015021-pol2qm74	2309	29	but	but	CC
cord-015021-pol2qm74	2309	30	not	not	RB
cord-015021-pol2qm74	2309	31	with	with	IN
cord-015021-pol2qm74	2309	32	a	a	DT
cord-015021-pol2qm74	2309	33	direct	direct	JJ
cord-015021-pol2qm74	2309	34	vasodilator	vasodilator	NN
cord-015021-pol2qm74	2309	35	(	(	-LRB-
cord-015021-pol2qm74	2309	36	NaNO2	NaNO2	NNP
cord-015021-pol2qm74	2309	37	)	)	-RRB-
cord-015021-pol2qm74	2309	38	.	.	.
cord-015021-pol2qm74	2310	1	This	this	DT
cord-015021-pol2qm74	2310	2	failure	failure	NN
cord-015021-pol2qm74	2310	3	to	to	TO
cord-015021-pol2qm74	2310	4	relax	relax	VB
cord-015021-pol2qm74	2310	5	to	to	IN
cord-015021-pol2qm74	2310	6	ACh	ACh	NNP
cord-015021-pol2qm74	2310	7	and	and	CC
cord-015021-pol2qm74	2310	8	A23187	A23187	NNP
cord-015021-pol2qm74	2310	9	reflects	reflect	VBZ
cord-015021-pol2qm74	2310	10	an	an	DT
cord-015021-pol2qm74	2310	11	inability	inability	NN
cord-015021-pol2qm74	2310	12	of	of	IN
cord-015021-pol2qm74	2310	13	endothelium	endothelium	NN
cord-015021-pol2qm74	2310	14	to	to	TO
cord-015021-pol2qm74	2310	15	generate	generate	VB
cord-015021-pol2qm74	2310	16	EDRF	EDRF	NNP
cord-015021-pol2qm74	2310	17	,	,	,
cord-015021-pol2qm74	2310	18	but	but	CC
cord-015021-pol2qm74	2310	19	relaxation	relaxation	NN
cord-015021-pol2qm74	2310	20	recovers	recover	VBZ
cord-015021-pol2qm74	2310	21	gradually	gradually	RB
cord-015021-pol2qm74	2310	22	to	to	TO
cord-015021-pol2qm74	2310	23	control	control	VB
cord-015021-pol2qm74	2310	24	values	value	NNS
cord-015021-pol2qm74	2310	25	by	by	IN
cord-015021-pol2qm74	2310	26	2	2	CD
cord-015021-pol2qm74	2310	27	weeks	week	NNS
cord-015021-pol2qm74	2310	28	.	.	.
cord-015021-pol2qm74	2311	1	Exogenous	exogenous	JJ
cord-015021-pol2qm74	2311	2	NO	no	DT
cord-015021-pol2qm74	2311	3	donors	donor	NNS
cord-015021-pol2qm74	2311	4	(	(	-LRB-
cord-015021-pol2qm74	2311	5	e.g.	e.g.	RB
cord-015021-pol2qm74	2311	6	,	,	,
cord-015021-pol2qm74	2311	7	C87	C87	NNP
cord-015021-pol2qm74	2311	8	-	-	HYPH
cord-015021-pol2qm74	2311	9	3754	3754	CD
cord-015021-pol2qm74	2311	10	or	or	CC
cord-015021-pol2qm74	2311	11	SPM-5185	SPM-5185	NNP
cord-015021-pol2qm74	2311	12	)	)	-RRB-
cord-015021-pol2qm74	2311	13	,	,	,
cord-015021-pol2qm74	2311	14	accelerate	accelerate	VB
cord-015021-pol2qm74	2311	15	the	the	DT
cord-015021-pol2qm74	2311	16	recovery	recovery	NN
cord-015021-pol2qm74	2311	17	of	of	IN
cord-015021-pol2qm74	2311	18	the	the	DT
cord-015021-pol2qm74	2311	19	injured	injured	JJ
cord-015021-pol2qm74	2311	20	endothelium	endothelium	NN
cord-015021-pol2qm74	2311	21	in	in	IN
cord-015021-pol2qm74	2311	22	rat	rat	NN
cord-015021-pol2qm74	2311	23	carotid	carotid	JJ
cord-015021-pol2qm74	2311	24	arteries	artery	NNS
cord-015021-pol2qm74	2311	25	.	.	.
cord-015021-pol2qm74	2312	1	Intravenous	intravenous	JJ
cord-015021-pol2qm74	2312	2	infusion	infusion	NN
cord-015021-pol2qm74	2312	3	of	of	IN
cord-015021-pol2qm74	2312	4	an	an	DT
cord-015021-pol2qm74	2312	5	NO	no	JJ
cord-015021-pol2qm74	2312	6	donor	donor	NN
cord-015021-pol2qm74	2312	7	(	(	-LRB-
cord-015021-pol2qm74	2312	8	30	30	CD
cord-015021-pol2qm74	2312	9	p.g	p.g	NNP
cord-015021-pol2qm74	2312	10	/	/	SYM
cord-015021-pol2qm74	2312	11	day	day	NN
cord-015021-pol2qm74	2312	12	)	)	-RRB-
cord-015021-pol2qm74	2312	13	with	with	IN
cord-015021-pol2qm74	2312	14	an	an	DT
cord-015021-pol2qm74	2312	15	implanted	implant	VBN
cord-015021-pol2qm74	2312	16	osmotic	osmotic	JJ
cord-015021-pol2qm74	2312	17	pump	pump	NN
cord-015021-pol2qm74	2312	18	significantly	significantly	RB
cord-015021-pol2qm74	2312	19	accelerated	accelerate	VBD
cord-015021-pol2qm74	2312	20	the	the	DT
cord-015021-pol2qm74	2312	21	recovery	recovery	NN
cord-015021-pol2qm74	2312	22	of	of	IN
cord-015021-pol2qm74	2312	23	regenerated	regenerated	JJ
cord-015021-pol2qm74	2312	24	endothelium	endothelium	NN
cord-015021-pol2qm74	2312	25	to	to	TO
cord-015021-pol2qm74	2312	26	produce	produce	VB
cord-015021-pol2qm74	2312	27	EDRF	EDRF	NNP
cord-015021-pol2qm74	2312	28	at	at	IN
cord-015021-pol2qm74	2312	29	7	7	CD
cord-015021-pol2qm74	2312	30	days	day	NNS
cord-015021-pol2qm74	2312	31	.	.	.
cord-015021-pol2qm74	2313	1	Rat	rat	NN
cord-015021-pol2qm74	2313	2	carotid	carotid	JJ
cord-015021-pol2qm74	2313	3	artery	artery	NN
cord-015021-pol2qm74	2313	4	rings	ring	NNS
cord-015021-pol2qm74	2313	5	relaxed	relax	VBN
cord-015021-pol2qm74	2313	6	only	only	RB
cord-015021-pol2qm74	2313	7	17	17	CD
cord-015021-pol2qm74	2313	8	+	+	SYM
cord-015021-pol2qm74	2313	9	5	5	CD
cord-015021-pol2qm74	2313	10	%	%	NN
cord-015021-pol2qm74	2313	11	and	and	CC
cord-015021-pol2qm74	2313	12	15	15	CD
cord-015021-pol2qm74	2313	13	+	+	CD
cord-015021-pol2qm74	2314	1	5	5	CD
cord-015021-pol2qm74	2314	2	%	%	NN
cord-015021-pol2qm74	2314	3	to	to	TO
cord-015021-pol2qm74	2314	4	10	10	CD
cord-015021-pol2qm74	2314	5	gM	gm	NN
cord-015021-pol2qm74	2314	6	ACh	ACh	NNP
cord-015021-pol2qm74	2314	7	in	in	IN
cord-015021-pol2qm74	2314	8	vehicle	vehicle	NN
cord-015021-pol2qm74	2314	9	treated	treat	VBD
cord-015021-pol2qm74	2314	10	rats	rat	NNS
cord-015021-pol2qm74	2314	11	and	and	CC
cord-015021-pol2qm74	2314	12	in	in	IN
cord-015021-pol2qm74	2314	13	inactive	inactive	JJ
cord-015021-pol2qm74	2314	14	NO	no	DT
cord-015021-pol2qm74	2314	15	donor	donor	NN
cord-015021-pol2qm74	2314	16	treated	treat	VBN
cord-015021-pol2qm74	2314	17	rats	rat	NNS
cord-015021-pol2qm74	2314	18	respectively	respectively	RB
cord-015021-pol2qm74	2314	19	7	7	CD
cord-015021-pol2qm74	2314	20	days	day	NNS
cord-015021-pol2qm74	2314	21	following	follow	VBG
cord-015021-pol2qm74	2314	22	injury	injury	NN
cord-015021-pol2qm74	2314	23	compared	compare	VBN
cord-015021-pol2qm74	2314	24	with	with	IN
cord-015021-pol2qm74	2314	25	67	67	CD
cord-015021-pol2qm74	2314	26	+	+	SYM
cord-015021-pol2qm74	2314	27	6	6	CD
cord-015021-pol2qm74	2314	28	%	%	NN
cord-015021-pol2qm74	2314	29	in	in	IN
cord-015021-pol2qm74	2314	30	NO	no	DT
cord-015021-pol2qm74	2314	31	donor	donor	NN
cord-015021-pol2qm74	2314	32	rats	rat	NNS
cord-015021-pol2qm74	2314	33	(	(	-LRB-
cord-015021-pol2qm74	2314	34	p<0.001	p<0.001	CD
cord-015021-pol2qm74	2314	35	)	)	-RRB-
cord-015021-pol2qm74	2314	36	.	.	.
cord-015021-pol2qm74	2315	1	Relaxation	relaxation	NN
cord-015021-pol2qm74	2315	2	to	to	IN
cord-015021-pol2qm74	2315	3	100	100	CD
cord-015021-pol2qm74	2316	1	gM	gM	NNP
cord-015021-pol2qm74	2317	1	NAN02	NAN02	NNP
cord-015021-pol2qm74	2317	2	was	be	VBD
cord-015021-pol2qm74	2317	3	normal	normal	JJ
cord-015021-pol2qm74	2317	4	in	in	IN
cord-015021-pol2qm74	2317	5	all	all	DT
cord-015021-pol2qm74	2317	6	groups	group	NNS
cord-015021-pol2qm74	2317	7	indicating	indicate	VBG
cord-015021-pol2qm74	2317	8	that	that	IN
cord-015021-pol2qm74	2317	9	the	the	DT
cord-015021-pol2qm74	2317	10	differences	difference	NNS
cord-015021-pol2qm74	2317	11	in	in	IN
cord-015021-pol2qm74	2317	12	relaxation	relaxation	NN
cord-015021-pol2qm74	2317	13	were	be	VBD
cord-015021-pol2qm74	2317	14	not	not	RB
cord-015021-pol2qm74	2317	15	the	the	DT
cord-015021-pol2qm74	2317	16	result	result	NN
cord-015021-pol2qm74	2317	17	of	of	IN
cord-015021-pol2qm74	2317	18	damage	damage	NN
cord-015021-pol2qm74	2317	19	to	to	IN
cord-015021-pol2qm74	2317	20	vascular	vascular	JJ
cord-015021-pol2qm74	2317	21	smooth	smooth	JJ
cord-015021-pol2qm74	2317	22	muscle	muscle	NN
cord-015021-pol2qm74	2317	23	.	.	.
cord-015021-pol2qm74	2318	1	Contraction	contraction	NN
cord-015021-pol2qm74	2318	2	to	to	IN
cord-015021-pol2qm74	2318	3	L	l	NN
cord-015021-pol2qm74	2318	4	-	-	HYPH
cord-015021-pol2qm74	2318	5	NAME	NAME	NNP
cord-015021-pol2qm74	2318	6	(	(	-LRB-
cord-015021-pol2qm74	2318	7	1	1	CD
cord-015021-pol2qm74	2318	8	mM	mm	CD
cord-015021-pol2qm74	2318	9	)	)	-RRB-
cord-015021-pol2qm74	2318	10	was	be	VBD
cord-015021-pol2qm74	2318	11	markedly	markedly	RB
cord-015021-pol2qm74	2318	12	reduced	reduce	VBN
cord-015021-pol2qm74	2318	13	by	by	IN
cord-015021-pol2qm74	2318	14	injury	injury	NN
cord-015021-pol2qm74	2318	15	,	,	,
cord-015021-pol2qm74	2318	16	but	but	CC
cord-015021-pol2qm74	2318	17	was	be	VBD
cord-015021-pol2qm74	2318	18	protected	protect	VBN
cord-015021-pol2qm74	2318	19	by	by	IN
cord-015021-pol2qm74	2318	20	NO	no	DT
cord-015021-pol2qm74	2318	21	donors	donor	NNS
cord-015021-pol2qm74	2318	22	(	(	-LRB-
cord-015021-pol2qm74	2318	23	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	2318	24	)	)	-RRB-
cord-015021-pol2qm74	2318	25	.	.	.
cord-015021-pol2qm74	2319	1	Thus	thus	RB
cord-015021-pol2qm74	2319	2	,	,	,
cord-015021-pol2qm74	2319	3	exogenous	exogenous	JJ
cord-015021-pol2qm74	2319	4	NO	no	DT
cord-015021-pol2qm74	2319	5	donors	donor	NNS
cord-015021-pol2qm74	2319	6	enhance	enhance	VBP
cord-015021-pol2qm74	2319	7	the	the	DT
cord-015021-pol2qm74	2319	8	ability	ability	NN
cord-015021-pol2qm74	2319	9	of	of	IN
cord-015021-pol2qm74	2319	10	the	the	DT
cord-015021-pol2qm74	2319	11	endothelium	endothelium	NN
cord-015021-pol2qm74	2319	12	to	to	TO
cord-015021-pol2qm74	2319	13	regenerate	regenerate	VB
cord-015021-pol2qm74	2319	14	and	and	CC
cord-015021-pol2qm74	2319	15	to	to	TO
cord-015021-pol2qm74	2319	16	release	release	VB
cord-015021-pol2qm74	2319	17	EDRF	EDRF	NNP
cord-015021-pol2qm74	2319	18	in	in	IN
cord-015021-pol2qm74	2319	19	response	response	NN
cord-015021-pol2qm74	2319	20	to	to	IN
cord-015021-pol2qm74	2319	21	endothelium	endothelium	NN
cord-015021-pol2qm74	2319	22	-	-	HYPH
cord-015021-pol2qm74	2319	23	dependent	dependent	JJ
cord-015021-pol2qm74	2319	24	vasodilators	vasodilator	NNS
cord-015021-pol2qm74	2319	25	.	.	.
cord-015021-pol2qm74	2320	1	This	this	DT
cord-015021-pol2qm74	2320	2	may	may	MD
cord-015021-pol2qm74	2320	3	be	be	VB
cord-015021-pol2qm74	2320	4	due	due	JJ
cord-015021-pol2qm74	2320	5	to	to	IN
cord-015021-pol2qm74	2320	6	an	an	DT
cord-015021-pol2qm74	2320	7	anti	anti	JJ
cord-015021-pol2qm74	2320	8	-	-	JJ
cord-015021-pol2qm74	2320	9	proliferative	proliferative	JJ
cord-015021-pol2qm74	2320	10	and	and	CC
cord-015021-pol2qm74	2320	11	anti	anti	JJ
cord-015021-pol2qm74	2320	12	-	-	JJ
cord-015021-pol2qm74	2320	13	mitogenic	mitogenic	JJ
cord-015021-pol2qm74	2320	14	effect	effect	NN
cord-015021-pol2qm74	2320	15	of	of	IN
cord-015021-pol2qm74	2320	16	NO	no	DT
cord-015021-pol2qm74	2320	17	on	on	IN
cord-015021-pol2qm74	2320	18	vascular	vascular	JJ
cord-015021-pol2qm74	2320	19	smooth	smooth	JJ
cord-015021-pol2qm74	2320	20	muscle	muscle	NN
cord-015021-pol2qm74	2320	21	cells	cell	NNS
cord-015021-pol2qm74	2320	22	,	,	,
cord-015021-pol2qm74	2320	23	allowing	allow	VBG
cord-015021-pol2qm74	2320	24	the	the	DT
cord-015021-pol2qm74	2320	25	endothelium	endothelium	NN
cord-015021-pol2qm74	2320	26	to	to	TO
cord-015021-pol2qm74	2320	27	regenerate	regenerate	VB
cord-015021-pol2qm74	2320	28	without	without	IN
cord-015021-pol2qm74	2320	29	intimal	intimal	JJ
cord-015021-pol2qm74	2320	30	thickening	thickening	NN
cord-015021-pol2qm74	2320	31	.	.	.
cord-015021-pol2qm74	2321	1	NO	no	RB
cord-015021-pol2qm74	2321	2	also	also	RB
cord-015021-pol2qm74	2321	3	has	have	VBZ
cord-015021-pol2qm74	2321	4	been	be	VBN
cord-015021-pol2qm74	2321	5	shown	show	VBN
cord-015021-pol2qm74	2321	6	to	to	TO
cord-015021-pol2qm74	2321	7	inhibit	inhibit	VB
cord-015021-pol2qm74	2321	8	platelet	platelet	NN
cord-015021-pol2qm74	2321	9	aggregation	aggregation	NN
cord-015021-pol2qm74	2321	10	,	,	,
cord-015021-pol2qm74	2321	11	and	and	CC
cord-015021-pol2qm74	2321	12	to	to	TO
cord-015021-pol2qm74	2321	13	attenuate	attenuate	VB
cord-015021-pol2qm74	2321	14	neutrophil	neutrophil	NN
cord-015021-pol2qm74	2321	15	adherence	adherence	NN
cord-015021-pol2qm74	2321	16	and	and	CC
cord-015021-pol2qm74	2321	17	activation	activation	NN
cord-015021-pol2qm74	2321	18	.	.	.
cord-015021-pol2qm74	2322	1	The	the	DT
cord-015021-pol2qm74	2322	2	superoxide	superoxide	NN
cord-015021-pol2qm74	2322	3	scavenging	scavenging	NN
cord-015021-pol2qm74	2322	4	effect	effect	NN
cord-015021-pol2qm74	2322	5	of	of	IN
cord-015021-pol2qm74	2322	6	NO	no	DT
cord-015021-pol2qm74	2322	7	is	be	VBZ
cord-015021-pol2qm74	2322	8	not	not	RB
cord-015021-pol2qm74	2322	9	the	the	DT
cord-015021-pol2qm74	2322	10	basis	basis	NN
cord-015021-pol2qm74	2322	11	for	for	IN
cord-015021-pol2qm74	2322	12	these	these	DT
cord-015021-pol2qm74	2322	13	effects	effect	NNS
cord-015021-pol2qm74	2322	14	since	since	IN
cord-015021-pol2qm74	2322	15	hSOD	hSOD	NNP
cord-015021-pol2qm74	2322	16	is	be	VBZ
cord-015021-pol2qm74	2322	17	inactive	inactive	JJ
cord-015021-pol2qm74	2322	18	in	in	IN
cord-015021-pol2qm74	2322	19	preserving	preserve	VBG
cord-015021-pol2qm74	2322	20	endothelial	endothelial	JJ
cord-015021-pol2qm74	2322	21	function	function	NN
cord-015021-pol2qm74	2322	22	in	in	IN
cord-015021-pol2qm74	2322	23	injured	injure	VBN
cord-015021-pol2qm74	2322	24	arteries	artery	NNS
cord-015021-pol2qm74	2322	25	.	.	.
cord-015021-pol2qm74	2323	1	Thus	thus	RB
cord-015021-pol2qm74	2323	2	,	,	,
cord-015021-pol2qm74	2323	3	NO	no	DT
cord-015021-pol2qm74	2323	4	exerts	exert	VBZ
cord-015021-pol2qm74	2323	5	a	a	DT
cord-015021-pol2qm74	2323	6	variety	variety	NN
cord-015021-pol2qm74	2323	7	of	of	IN
cord-015021-pol2qm74	2323	8	cytoprotective	cytoprotective	JJ
cord-015021-pol2qm74	2323	9	effects	effect	NNS
cord-015021-pol2qm74	2323	10	which	which	WDT
cord-015021-pol2qm74	2323	11	may	may	MD
cord-015021-pol2qm74	2323	12	be	be	VB
cord-015021-pol2qm74	2323	13	of	of	IN
cord-015021-pol2qm74	2323	14	importance	importance	NN
cord-015021-pol2qm74	2323	15	in	in	IN
cord-015021-pol2qm74	2323	16	protecting	protect	VBG
cord-015021-pol2qm74	2323	17	against	against	IN
cord-015021-pol2qm74	2323	18	vascular	vascular	JJ
cord-015021-pol2qm74	2323	19	injury	injury	NN
cord-015021-pol2qm74	2323	20	.	.	.
cord-015021-pol2qm74	2324	1	Much	much	JJ
cord-015021-pol2qm74	2324	2	evidence	evidence	NN
cord-015021-pol2qm74	2324	3	has	have	VBZ
cord-015021-pol2qm74	2324	4	now	now	RB
cord-015021-pol2qm74	2324	5	accumulated	accumulate	VBN
cord-015021-pol2qm74	2324	6	to	to	TO
cord-015021-pol2qm74	2324	7	show	show	VB
cord-015021-pol2qm74	2324	8	that	that	IN
cord-015021-pol2qm74	2324	9	the	the	DT
cord-015021-pol2qm74	2324	10	excess	excess	JJ
cord-015021-pol2qm74	2324	11	production	production	NN
cord-015021-pol2qm74	2324	12	of	of	IN
cord-015021-pol2qm74	2324	13	the	the	DT
cord-015021-pol2qm74	2324	14	vasodilator	vasodilator	NN
cord-015021-pol2qm74	2324	15	nitric	nitric	NN
cord-015021-pol2qm74	2324	16	oxide	oxide	NN
cord-015021-pol2qm74	2324	17	(	(	-LRB-
cord-015021-pol2qm74	2324	18	NO	no	UH
cord-015021-pol2qm74	2324	19	)	)	-RRB-
cord-015021-pol2qm74	2324	20	in	in	IN
cord-015021-pol2qm74	2324	21	sepsis	sepsis	NN
cord-015021-pol2qm74	2324	22	is	be	VBZ
cord-015021-pol2qm74	2324	23	an	an	DT
cord-015021-pol2qm74	2324	24	important	important	JJ
cord-015021-pol2qm74	2324	25	contributor	contributor	NN
cord-015021-pol2qm74	2324	26	to	to	IN
cord-015021-pol2qm74	2324	27	the	the	DT
cord-015021-pol2qm74	2324	28	hypotension	hypotension	NN
cord-015021-pol2qm74	2324	29	and	and	CC
cord-015021-pol2qm74	2324	30	multiorgan	multiorgan	NN
cord-015021-pol2qm74	2324	31	failure	failure	NN
cord-015021-pol2qm74	2324	32	characteristic	characteristic	JJ
cord-015021-pol2qm74	2324	33	of	of	IN
cord-015021-pol2qm74	2324	34	this	this	DT
cord-015021-pol2qm74	2324	35	condition	condition	NN
cord-015021-pol2qm74	2324	36	.	.	.
cord-015021-pol2qm74	2325	1	Various	various	JJ
cord-015021-pol2qm74	2325	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	2325	3	play	play	VBP
cord-015021-pol2qm74	2325	4	an	an	DT
cord-015021-pol2qm74	2325	5	important	important	JJ
cord-015021-pol2qm74	2325	6	role	role	NN
cord-015021-pol2qm74	2325	7	in	in	IN
cord-015021-pol2qm74	2325	8	this	this	DT
cord-015021-pol2qm74	2325	9	process	process	NN
cord-015021-pol2qm74	2325	10	through	through	IN
cord-015021-pol2qm74	2325	11	their	-PRON-	PRP$
cord-015021-pol2qm74	2325	12	ability	ability	NN
cord-015021-pol2qm74	2325	13	to	to	TO
cord-015021-pol2qm74	2325	14	induce	induce	VB
cord-015021-pol2qm74	2325	15	the	the	DT
cord-015021-pol2qm74	2325	16	production	production	NN
cord-015021-pol2qm74	2325	17	of	of	IN
cord-015021-pol2qm74	2325	18	one	one	CD
cord-015021-pol2qm74	2325	19	of	of	IN
cord-015021-pol2qm74	2325	20	the	the	DT
cord-015021-pol2qm74	2325	21	enzymes	enzyme	NNS
cord-015021-pol2qm74	2325	22	responsible	responsible	JJ
cord-015021-pol2qm74	2325	23	for	for	IN
cord-015021-pol2qm74	2325	24	NO	no	DT
cord-015021-pol2qm74	2325	25	synthesis	synthesis	NN
cord-015021-pol2qm74	2325	26	,	,	,
cord-015021-pol2qm74	2325	27	the	the	DT
cord-015021-pol2qm74	2325	28	inducible	inducible	JJ
cord-015021-pol2qm74	2325	29	NO	no	DT
cord-015021-pol2qm74	2325	30	synthase	synthase	NN
cord-015021-pol2qm74	2325	31	(	(	-LRB-
cord-015021-pol2qm74	2325	32	iNOS	inos	NN
cord-015021-pol2qm74	2325	33	)	)	-RRB-
cord-015021-pol2qm74	2325	34	.	.	.
cord-015021-pol2qm74	2326	1	We	-PRON-	PRP
cord-015021-pol2qm74	2326	2	have	have	VBP
cord-015021-pol2qm74	2326	3	studied	study	VBN
cord-015021-pol2qm74	2326	4	the	the	DT
cord-015021-pol2qm74	2326	5	effects	effect	NNS
cord-015021-pol2qm74	2326	6	of	of	IN
cord-015021-pol2qm74	2326	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	2326	8	on	on	IN
cord-015021-pol2qm74	2326	9	the	the	DT
cord-015021-pol2qm74	2326	10	induction	induction	NN
cord-015021-pol2qm74	2326	11	of	of	IN
cord-015021-pol2qm74	2326	12	this	this	DT
cord-015021-pol2qm74	2326	13	enzyme	enzyme	NN
cord-015021-pol2qm74	2326	14	both	both	DT
cord-015021-pol2qm74	2326	15	in	in	IN
cord-015021-pol2qm74	2326	16	vitro	vitro	FW
cord-015021-pol2qm74	2326	17	using	use	VBG
cord-015021-pol2qm74	2326	18	vascular	vascular	JJ
cord-015021-pol2qm74	2326	19	smooth	smooth	JJ
cord-015021-pol2qm74	2326	20	muscle	muscle	NN
cord-015021-pol2qm74	2326	21	cells	cell	NNS
cord-015021-pol2qm74	2326	22	,	,	,
cord-015021-pol2qm74	2326	23	and	and	CC
cord-015021-pol2qm74	2326	24	in	in	IN
cord-015021-pol2qm74	2326	25	a	a	DT
cord-015021-pol2qm74	2326	26	murine	murine	JJ
cord-015021-pol2qm74	2326	27	model	model	NN
cord-015021-pol2qm74	2326	28	of	of	IN
cord-015021-pol2qm74	2326	29	Gram	gram	NN
cord-015021-pol2qm74	2326	30	-	-	HYPH
cord-015021-pol2qm74	2326	31	negative	negative	JJ
cord-015021-pol2qm74	2326	32	sepsis	sepsis	NN
cord-015021-pol2qm74	2326	33	.	.	.
cord-015021-pol2qm74	2327	1	tn	tn	NNP
cord-015021-pol2qm74	2327	2	smooth	smooth	JJ
cord-015021-pol2qm74	2327	3	muscle	muscle	NN
cord-015021-pol2qm74	2327	4	ceils	ceil	NNS
cord-015021-pol2qm74	2327	5	,	,	,
cord-015021-pol2qm74	2327	6	the	the	DT
cord-015021-pol2qm74	2327	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	2327	8	IL-1	IL-1	NNP
cord-015021-pol2qm74	2327	9	,	,	,
cord-015021-pol2qm74	2327	10	IFNq	IFNq	NNS
cord-015021-pol2qm74	2327	11	'	'	''
cord-015021-pol2qm74	2327	12	,	,	,
cord-015021-pol2qm74	2327	13	and	and	CC
cord-015021-pol2qm74	2327	14	TNF	TNF	NNP
cord-015021-pol2qm74	2327	15	-	-	HYPH
cord-015021-pol2qm74	2327	16	oc	oc	NNP
cord-015021-pol2qm74	2327	17	show	show	VBP
cord-015021-pol2qm74	2327	18	strong	strong	JJ
cord-015021-pol2qm74	2327	19	synergy	synergy	NN
cord-015021-pol2qm74	2327	20	with	with	IN
cord-015021-pol2qm74	2327	21	one	one	CD
cord-015021-pol2qm74	2327	22	another	another	DT
cord-015021-pol2qm74	2327	23	in	in	IN
cord-015021-pol2qm74	2327	24	the	the	DT
cord-015021-pol2qm74	2327	25	production	production	NN
cord-015021-pol2qm74	2327	26	of	of	IN
cord-015021-pol2qm74	2327	27	iNOS	inos	NN
cord-015021-pol2qm74	2327	28	.	.	.
cord-015021-pol2qm74	2328	1	In	in	IN
cord-015021-pol2qm74	2328	2	order	order	NN
cord-015021-pol2qm74	2328	3	to	to	TO
cord-015021-pol2qm74	2328	4	define	define	VB
cord-015021-pol2qm74	2328	5	the	the	DT
cord-015021-pol2qm74	2328	6	molecular	molecular	JJ
cord-015021-pol2qm74	2328	7	basis	basis	NN
cord-015021-pol2qm74	2328	8	for	for	IN
cord-015021-pol2qm74	2328	9	this	this	DT
cord-015021-pol2qm74	2328	10	synergic	synergic	JJ
cord-015021-pol2qm74	2328	11	effect	effect	NN
cord-015021-pol2qm74	2328	12	,	,	,
cord-015021-pol2qm74	2328	13	we	-PRON-	PRP
cord-015021-pol2qm74	2328	14	have	have	VBP
cord-015021-pol2qm74	2328	15	linked	link	VBN
cord-015021-pol2qm74	2328	16	the	the	DT
cord-015021-pol2qm74	2328	17	promoter	promoter	NN
cord-015021-pol2qm74	2328	18	of	of	IN
cord-015021-pol2qm74	2328	19	the	the	DT
cord-015021-pol2qm74	2328	20	iNOS	inos	JJ
cord-015021-pol2qm74	2328	21	gene	gene	NN
cord-015021-pol2qm74	2328	22	to	to	IN
cord-015021-pol2qm74	2328	23	a	a	DT
cord-015021-pol2qm74	2328	24	"	"	``
cord-015021-pol2qm74	2328	25	reporter	reporter	NN
cord-015021-pol2qm74	2328	26	"	"	''
cord-015021-pol2qm74	2328	27	gene	gene	NN
cord-015021-pol2qm74	2328	28	,	,	,
cord-015021-pol2qm74	2328	29	chloramphenicol	chloramphenicol	NN
cord-015021-pol2qm74	2328	30	acetyl	acetyl	NN
cord-015021-pol2qm74	2328	31	transferase	transferase	NN
cord-015021-pol2qm74	2328	32	(	(	-LRB-
cord-015021-pol2qm74	2328	33	CAT	CAT	NNP
cord-015021-pol2qm74	2328	34	)	)	-RRB-
cord-015021-pol2qm74	2328	35	,	,	,
cord-015021-pol2qm74	2328	36	and	and	CC
cord-015021-pol2qm74	2328	37	transfected	transfecte	VBD
cord-015021-pol2qm74	2328	38	these	these	DT
cord-015021-pol2qm74	2328	39	constructs	construct	NNS
cord-015021-pol2qm74	2328	40	into	into	IN
cord-015021-pol2qm74	2328	41	vascular	vascular	JJ
cord-015021-pol2qm74	2328	42	smooth	smooth	JJ
cord-015021-pol2qm74	2328	43	muscle	muscle	NN
cord-015021-pol2qm74	2328	44	cells	cell	NNS
cord-015021-pol2qm74	2328	45	.	.	.
cord-015021-pol2qm74	2329	1	Assays	assay	NNS
cord-015021-pol2qm74	2329	2	of	of	IN
cord-015021-pol2qm74	2329	3	CAT	cat	NN
cord-015021-pol2qm74	2329	4	activity	activity	NN
cord-015021-pol2qm74	2329	5	reflect	reflect	VBP
cord-015021-pol2qm74	2329	6	the	the	DT
cord-015021-pol2qm74	2329	7	activity	activity	NN
cord-015021-pol2qm74	2329	8	of	of	IN
cord-015021-pol2qm74	2329	9	the	the	DT
cord-015021-pol2qm74	2329	10	promoter	promoter	NN
cord-015021-pol2qm74	2329	11	in	in	IN
cord-015021-pol2qm74	2329	12	this	this	DT
cord-015021-pol2qm74	2329	13	system	system	NN
cord-015021-pol2qm74	2329	14	,	,	,
cord-015021-pol2qm74	2329	15	and	and	CC
cord-015021-pol2qm74	2329	16	by	by	IN
cord-015021-pol2qm74	2329	17	generating	generate	VBG
cord-015021-pol2qm74	2329	18	sets	set	NNS
cord-015021-pol2qm74	2329	19	of	of	IN
cord-015021-pol2qm74	2329	20	deletion	deletion	NN
cord-015021-pol2qm74	2329	21	mutants	mutant	NNS
cord-015021-pol2qm74	2329	22	of	of	IN
cord-015021-pol2qm74	2329	23	the	the	DT
cord-015021-pol2qm74	2329	24	promoter	promoter	NN
cord-015021-pol2qm74	2329	25	sequence	sequence	NN
cord-015021-pol2qm74	2329	26	we	-PRON-	PRP
cord-015021-pol2qm74	2329	27	have	have	VBP
cord-015021-pol2qm74	2329	28	been	be	VBN
cord-015021-pol2qm74	2329	29	able	able	JJ
cord-015021-pol2qm74	2329	30	to	to	TO
cord-015021-pol2qm74	2329	31	define	define	VB
cord-015021-pol2qm74	2329	32	the	the	DT
cord-015021-pol2qm74	2329	33	area	area	NN
cord-015021-pol2qm74	2329	34	within	within	IN
cord-015021-pol2qm74	2329	35	the	the	DT
cord-015021-pol2qm74	2329	36	promoter	promoter	NN
cord-015021-pol2qm74	2329	37	which	which	WDT
cord-015021-pol2qm74	2329	38	mediates	mediate	VBZ
cord-015021-pol2qm74	2329	39	the	the	DT
cord-015021-pol2qm74	2329	40	synergic	synergic	JJ
cord-015021-pol2qm74	2329	41	effect	effect	NN
cord-015021-pol2qm74	2329	42	of	of	IN
cord-015021-pol2qm74	2329	43	these	these	DT
cord-015021-pol2qm74	2329	44	cytokines	cytokine	NNS
cord-015021-pol2qm74	2329	45	.	.	.
cord-015021-pol2qm74	2330	1	In	in	IN
cord-015021-pol2qm74	2330	2	addition	addition	NN
cord-015021-pol2qm74	2330	3	to	to	IN
cord-015021-pol2qm74	2330	4	stimufatory	stimufatory	JJ
cord-015021-pol2qm74	2330	5	effects	effect	NNS
cord-015021-pol2qm74	2330	6	on	on	IN
cord-015021-pol2qm74	2330	7	iNOS	inos	JJ
cord-015021-pol2qm74	2330	8	production	production	NN
cord-015021-pol2qm74	2330	9	,	,	,
cord-015021-pol2qm74	2330	10	certain	certain	JJ
cord-015021-pol2qm74	2330	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	2330	12	are	be	VBP
cord-015021-pol2qm74	2330	13	able	able	JJ
cord-015021-pol2qm74	2330	14	to	to	TO
cord-015021-pol2qm74	2330	15	down	down	VB
cord-015021-pol2qm74	2330	16	-	-	HYPH
cord-015021-pol2qm74	2330	17	regulate	regulate	VB
cord-015021-pol2qm74	2330	18	the	the	DT
cord-015021-pol2qm74	2330	19	production	production	NN
cord-015021-pol2qm74	2330	20	of	of	IN
cord-015021-pol2qm74	2330	21	iNOS	inos	NN
cord-015021-pol2qm74	2330	22	in	in	IN
cord-015021-pol2qm74	2330	23	vascular	vascular	JJ
cord-015021-pol2qm74	2330	24	smooth	smooth	JJ
cord-015021-pol2qm74	2330	25	muscle	muscle	NN
cord-015021-pol2qm74	2330	26	cells	cell	NNS
cord-015021-pol2qm74	2330	27	,	,	,
cord-015021-pol2qm74	2330	28	and	and	CC
cord-015021-pol2qm74	2330	29	the	the	DT
cord-015021-pol2qm74	2330	30	effects	effect	NNS
cord-015021-pol2qm74	2330	31	of	of	IN
cord-015021-pol2qm74	2330	32	these	these	DT
cord-015021-pol2qm74	2330	33	counterregulatory	counterregulatory	JJ
cord-015021-pol2qm74	2330	34	cytokines	cytokine	NNS
cord-015021-pol2qm74	2330	35	will	will	MD
cord-015021-pol2qm74	2330	36	be	be	VB
cord-015021-pol2qm74	2330	37	discussed	discuss	VBN
cord-015021-pol2qm74	2330	38	.	.	.
cord-015021-pol2qm74	2331	1	The	the	DT
cord-015021-pol2qm74	2331	2	interaction	interaction	NN
cord-015021-pol2qm74	2331	3	of	of	IN
cord-015021-pol2qm74	2331	4	these	these	DT
cord-015021-pol2qm74	2331	5	cytokine	cytokine	JJ
cord-015021-pol2qm74	2331	6	effects	effect	NNS
cord-015021-pol2qm74	2331	7	in	in	IN
cord-015021-pol2qm74	2331	8	the	the	DT
cord-015021-pol2qm74	2331	9	whole	whole	JJ
cord-015021-pol2qm74	2331	10	organism	organism	NN
cord-015021-pol2qm74	2331	11	has	have	VBZ
cord-015021-pol2qm74	2331	12	been	be	VBN
cord-015021-pol2qm74	2331	13	studied	study	VBN
cord-015021-pol2qm74	2331	14	in	in	IN
cord-015021-pol2qm74	2331	15	a	a	DT
cord-015021-pol2qm74	2331	16	murine	murine	JJ
cord-015021-pol2qm74	2331	17	model	model	NN
cord-015021-pol2qm74	2331	18	of	of	IN
cord-015021-pol2qm74	2331	19	Gramnegative	Gramnegative	NNP
cord-015021-pol2qm74	2331	20	sepsis	sepsis	NN
cord-015021-pol2qm74	2331	21	.	.	.
cord-015021-pol2qm74	2332	1	Widespread	widespread	JJ
cord-015021-pol2qm74	2332	2	induction	induction	NN
cord-015021-pol2qm74	2332	3	of	of	IN
cord-015021-pol2qm74	2332	4	iNOS	inos	NN
cord-015021-pol2qm74	2332	5	occurs	occur	NNS
cord-015021-pol2qm74	2332	6	in	in	IN
cord-015021-pol2qm74	2332	7	this	this	DT
cord-015021-pol2qm74	2332	8	model	model	NN
cord-015021-pol2qm74	2332	9	as	as	IN
cord-015021-pol2qm74	2332	10	assayed	assay	VBN
cord-015021-pol2qm74	2332	11	by	by	IN
cord-015021-pol2qm74	2332	12	enzyme	enzyme	NN
cord-015021-pol2qm74	2332	13	activity	activity	NN
cord-015021-pol2qm74	2332	14	and	and	CC
cord-015021-pol2qm74	2332	15	through	through	IN
cord-015021-pol2qm74	2332	16	use	use	NN
cord-015021-pol2qm74	2332	17	of	of	IN
cord-015021-pol2qm74	2332	18	specific	specific	JJ
cord-015021-pol2qm74	2332	19	antisera	antisera	NN
cord-015021-pol2qm74	2332	20	to	to	IN
cord-015021-pol2qm74	2332	21	iNOS	inos	NN
cord-015021-pol2qm74	2332	22	.	.	.
cord-015021-pol2qm74	2333	1	Neutralizing	neutralize	VBG
cord-015021-pol2qm74	2333	2	antibodies	antibody	NNS
cord-015021-pol2qm74	2333	3	to	to	IN
cord-015021-pol2qm74	2333	4	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	2333	5	and	and	CC
cord-015021-pol2qm74	2333	6	tFN	tFN	NNP
cord-015021-pol2qm74	2333	7	-	-	HYPH
cord-015021-pol2qm74	2333	8	y	y	NNP
cord-015021-pol2qm74	2333	9	are	be	VBP
cord-015021-pol2qm74	2333	10	both	both	DT
cord-015021-pol2qm74	2333	11	able	able	JJ
cord-015021-pol2qm74	2333	12	to	to	TO
cord-015021-pol2qm74	2333	13	prevent	prevent	VB
cord-015021-pol2qm74	2333	14	death	death	NN
cord-015021-pol2qm74	2333	15	in	in	IN
cord-015021-pol2qm74	2333	16	this	this	DT
cord-015021-pol2qm74	2333	17	model	model	NN
cord-015021-pol2qm74	2333	18	,	,	,
cord-015021-pol2qm74	2333	19	but	but	CC
cord-015021-pol2qm74	2333	20	it	-PRON-	PRP
cord-015021-pol2qm74	2333	21	is	be	VBZ
cord-015021-pol2qm74	2333	22	only	only	RB
cord-015021-pol2qm74	2333	23	the	the	DT
cord-015021-pol2qm74	2333	24	anti	anti	JJ
cord-015021-pol2qm74	2333	25	-	-	JJ
cord-015021-pol2qm74	2333	26	IFN	IFN	NNP
cord-015021-pol2qm74	2333	27	-	-	HYPH
cord-015021-pol2qm74	2333	28	y	y	NNP
cord-015021-pol2qm74	2333	29	which	which	WDT
cord-015021-pol2qm74	2333	30	attenuates	attenuate	VBZ
cord-015021-pol2qm74	2333	31	the	the	DT
cord-015021-pol2qm74	2333	32	induction	induction	NN
cord-015021-pol2qm74	2333	33	of	of	IN
cord-015021-pol2qm74	2333	34	iNOS	inos	JJ
cord-015021-pol2qm74	2333	35	assayed	assay	VBN
cord-015021-pol2qm74	2333	36	in	in	IN
cord-015021-pol2qm74	2333	37	the	the	DT
cord-015021-pol2qm74	2333	38	liver	liver	NN
cord-015021-pol2qm74	2333	39	.	.	.
cord-015021-pol2qm74	2334	1	Clearly	clearly	RB
cord-015021-pol2qm74	2334	2	there	there	EX
cord-015021-pol2qm74	2334	3	is	be	VBZ
cord-015021-pol2qm74	2334	4	some	some	DT
cord-015021-pol2qm74	2334	5	redundancy	redundancy	NN
cord-015021-pol2qm74	2334	6	in	in	IN
cord-015021-pol2qm74	2334	7	the	the	DT
cord-015021-pol2qm74	2334	8	effects	effect	NNS
cord-015021-pol2qm74	2334	9	of	of	IN
cord-015021-pol2qm74	2334	10	cytokines	cytokine	NNS
cord-015021-pol2qm74	2334	11	on	on	IN
cord-015021-pol2qm74	2334	12	the	the	DT
cord-015021-pol2qm74	2334	13	production	production	NN
cord-015021-pol2qm74	2334	14	of	of	IN
cord-015021-pol2qm74	2334	15	iNOS	inos	NN
cord-015021-pol2qm74	2334	16	in	in	IN
cord-015021-pol2qm74	2334	17	sepsis	sepsis	NN
cord-015021-pol2qm74	2334	18	,	,	,
cord-015021-pol2qm74	2334	19	and	and	CC
cord-015021-pol2qm74	2334	20	greater	great	JJR
cord-015021-pol2qm74	2334	21	understanding	understanding	NN
cord-015021-pol2qm74	2334	22	of	of	IN
cord-015021-pol2qm74	2334	23	the	the	DT
cord-015021-pol2qm74	2334	24	most	most	RBS
cord-015021-pol2qm74	2334	25	important	important	JJ
cord-015021-pol2qm74	2334	26	factors	factor	NNS
cord-015021-pol2qm74	2334	27	in	in	IN
cord-015021-pol2qm74	2334	28	iNOS	inos	JJ
cord-015021-pol2qm74	2334	29	production	production	NN
cord-015021-pol2qm74	2334	30	is	be	VBZ
cord-015021-pol2qm74	2334	31	required	require	VBN
cord-015021-pol2qm74	2334	32	in	in	IN
cord-015021-pol2qm74	2334	33	order	order	NN
cord-015021-pol2qm74	2334	34	to	to	TO
cord-015021-pol2qm74	2334	35	target	target	VB
cord-015021-pol2qm74	2334	36	anti	anti	JJ
cord-015021-pol2qm74	2334	37	-	-	JJ
cord-015021-pol2qm74	2334	38	cytokine	cytokine	JJ
cord-015021-pol2qm74	2334	39	therapy	therapy	NN
cord-015021-pol2qm74	2334	40	most	most	RBS
cord-015021-pol2qm74	2334	41	appropriately	appropriately	RB
cord-015021-pol2qm74	2334	42	.	.	.
cord-015021-pol2qm74	2334	43	 	 	_SP
cord-015021-pol2qm74	2335	1	Effects	effect	NNS
cord-015021-pol2qm74	2335	2	of	of	IN
cord-015021-pol2qm74	2335	3	nitric	nitric	NN
cord-015021-pol2qm74	2335	4	oxide	oxide	NN
cord-015021-pol2qm74	2335	5	on	on	IN
cord-015021-pol2qm74	2335	6	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	2335	7	metabolism	metabolism	NN
cord-015021-pol2qm74	2335	8	in	in	IN
cord-015021-pol2qm74	2335	9	inflammation	inflammation	NN
cord-015021-pol2qm74	2335	10	.	.	.
cord-015021-pol2qm74	2336	1	J.	J.	NNP
cord-015021-pol2qm74	2336	2	Stadler	Stadler	NNP
cord-015021-pol2qm74	2336	3	,	,	,
cord-015021-pol2qm74	2336	4	Department	Department	NNP
cord-015021-pol2qm74	2336	5	of	of	IN
cord-015021-pol2qm74	2336	6	Surgery	Surgery	NNP
cord-015021-pol2qm74	2336	7	,	,	,
cord-015021-pol2qm74	2336	8	TU	TU	NNP
cord-015021-pol2qm74	2336	9	MQnchen	MQnchen	NNP
cord-015021-pol2qm74	2336	10	,	,	,
cord-015021-pol2qm74	2336	11	FRG	FRG	NNP
cord-015021-pol2qm74	2336	12	Hepatocellular	Hepatocellular	NNP
cord-015021-pol2qm74	2336	13	nitric	nitric	NN
cord-015021-pol2qm74	2336	14	oxide	oxide	NN
cord-015021-pol2qm74	2337	1	(	(	-LRB-
cord-015021-pol2qm74	2337	2	NO	no	DT
cord-015021-pol2qm74	2337	3	)	)	-RRB-
cord-015021-pol2qm74	2337	4	synthesis	synthesis	NN
cord-015021-pol2qm74	2337	5	is	be	VBZ
cord-015021-pol2qm74	2337	6	induced	induce	VBN
cord-015021-pol2qm74	2337	7	by	by	IN
cord-015021-pol2qm74	2337	8	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	2337	9	mediators	mediator	NNS
cord-015021-pol2qm74	2337	10	such	such	JJ
cord-015021-pol2qm74	2337	11	as	as	IN
cord-015021-pol2qm74	2337	12	tumor	tumor	NN
cord-015021-pol2qm74	2337	13	necrosis	necrosis	NN
cord-015021-pol2qm74	2337	14	factor	factor	NN
cord-015021-pol2qm74	2337	15	,	,	,
cord-015021-pol2qm74	2337	16	interleukin-1	interleukin-1	NN
cord-015021-pol2qm74	2337	17	and	and	CC
cord-015021-pol2qm74	2337	18	interferon	interferon	NN
cord-015021-pol2qm74	2337	19	gamma	gamma	NN
cord-015021-pol2qm74	2337	20	or	or	CC
cord-015021-pol2qm74	2337	21	by	by	IN
cord-015021-pol2qm74	2337	22	bacterial	bacterial	JJ
cord-015021-pol2qm74	2337	23	toxins	toxin	NNS
cord-015021-pol2qm74	2337	24	such	such	JJ
cord-015021-pol2qm74	2337	25	as	as	IN
cord-015021-pol2qm74	2337	26	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	2337	27	.	.	.
cord-015021-pol2qm74	2338	1	Stimulation	stimulation	NN
cord-015021-pol2qm74	2338	2	of	of	IN
cord-015021-pol2qm74	2338	3	the	the	DT
cord-015021-pol2qm74	2338	4	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	2338	5	(	(	-LRB-
cord-015021-pol2qm74	2338	6	HC	HC	NNP
cord-015021-pol2qm74	2338	7	)	)	-RRB-
cord-015021-pol2qm74	2338	8	with	with	IN
cord-015021-pol2qm74	2338	9	a	a	DT
cord-015021-pol2qm74	2338	10	combination	combination	NN
cord-015021-pol2qm74	2338	11	of	of	IN
cord-015021-pol2qm74	2338	12	these	these	DT
cord-015021-pol2qm74	2338	13	agents	agent	NNS
cord-015021-pol2qm74	2338	14	leads	lead	VBZ
cord-015021-pol2qm74	2338	15	to	to	IN
cord-015021-pol2qm74	2338	16	an	an	DT
cord-015021-pol2qm74	2338	17	output	output	NN
cord-015021-pol2qm74	2338	18	of	of	IN
cord-015021-pol2qm74	2338	19	NO	no	DT
cord-015021-pol2qm74	2338	20	in	in	IN
cord-015021-pol2qm74	2338	21	quantities	quantity	NNS
cord-015021-pol2qm74	2338	22	which	which	WDT
cord-015021-pol2qm74	2338	23	are	be	VBP
cord-015021-pol2qm74	2338	24	not	not	RB
cord-015021-pol2qm74	2338	25	seen	see	VBN
cord-015021-pol2qm74	2338	26	in	in	IN
cord-015021-pol2qm74	2338	27	any	any	DT
cord-015021-pol2qm74	2338	28	other	other	JJ
cord-015021-pol2qm74	2338	29	celltype	celltype	NN
cord-015021-pol2qm74	2338	30	.	.	.
cord-015021-pol2qm74	2339	1	It	-PRON-	PRP
cord-015021-pol2qm74	2339	2	has	have	VBZ
cord-015021-pol2qm74	2339	3	been	be	VBN
cord-015021-pol2qm74	2339	4	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2339	5	by	by	IN
cord-015021-pol2qm74	2339	6	various	various	JJ
cord-015021-pol2qm74	2339	7	investigators	investigator	NNS
cord-015021-pol2qm74	2339	8	that	that	IN
cord-015021-pol2qm74	2339	9	important	important	JJ
cord-015021-pol2qm74	2339	10	effects	effect	NNS
cord-015021-pol2qm74	2339	11	of	of	IN
cord-015021-pol2qm74	2339	12	these	these	DT
cord-015021-pol2qm74	2339	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	2339	14	and	and	CC
cord-015021-pol2qm74	2339	15	bacterial	bacterial	JJ
cord-015021-pol2qm74	2339	16	toxins	toxin	NNS
cord-015021-pol2qm74	2339	17	on	on	IN
cord-015021-pol2qm74	2339	18	HC	HC	NNP
cord-015021-pol2qm74	2339	19	metabolism	metabolism	NN
cord-015021-pol2qm74	2339	20	can	can	MD
cord-015021-pol2qm74	2339	21	be	be	VB
cord-015021-pol2qm74	2339	22	attributed	attribute	VBN
cord-015021-pol2qm74	2339	23	to	to	IN
cord-015021-pol2qm74	2339	24	the	the	DT
cord-015021-pol2qm74	2339	25	action	action	NN
cord-015021-pol2qm74	2339	26	of	of	IN
cord-015021-pol2qm74	2339	27	NO	no	NN
cord-015021-pol2qm74	2339	28	.	.	.
cord-015021-pol2qm74	2340	1	In	in	IN
cord-015021-pol2qm74	2340	2	contrast	contrast	NN
cord-015021-pol2qm74	2340	3	to	to	IN
cord-015021-pol2qm74	2340	4	other	other	JJ
cord-015021-pol2qm74	2340	5	celltypes	celltype	NNS
cord-015021-pol2qm74	2340	6	HC	HC	NNP
cord-015021-pol2qm74	2340	7	seem	seem	VBP
cord-015021-pol2qm74	2340	8	to	to	TO
cord-015021-pol2qm74	2340	9	be	be	VB
cord-015021-pol2qm74	2340	10	relatively	relatively	RB
cord-015021-pol2qm74	2340	11	resistant	resistant	JJ
cord-015021-pol2qm74	2340	12	to	to	IN
cord-015021-pol2qm74	2340	13	suppression	suppression	NN
cord-015021-pol2qm74	2340	14	of	of	IN
cord-015021-pol2qm74	2340	15	basic	basic	JJ
cord-015021-pol2qm74	2340	16	metabolic	metabolic	JJ
cord-015021-pol2qm74	2340	17	functions	function	NNS
cord-015021-pol2qm74	2340	18	such	such	JJ
cord-015021-pol2qm74	2340	19	as	as	IN
cord-015021-pol2qm74	2340	20	energy	energy	NN
cord-015021-pol2qm74	2340	21	metabolism	metabolism	NN
cord-015021-pol2qm74	2340	22	by	by	IN
cord-015021-pol2qm74	2340	23	NO	no	NN
cord-015021-pol2qm74	2340	24	.	.	.
cord-015021-pol2qm74	2341	1	Therefore	therefore	RB
cord-015021-pol2qm74	2341	2	,	,	,
cord-015021-pol2qm74	2341	3	cell	cell	NN
cord-015021-pol2qm74	2341	4	damage	damage	NN
cord-015021-pol2qm74	2341	5	has	have	VBZ
cord-015021-pol2qm74	2341	6	not	not	RB
cord-015021-pol2qm74	2341	7	been	be	VBN
cord-015021-pol2qm74	2341	8	described	describe	VBN
cord-015021-pol2qm74	2341	9	to	to	IN
cord-015021-pol2qm74	2341	10	a	a	DT
cord-015021-pol2qm74	2341	11	significant	significant	JJ
cord-015021-pol2qm74	2341	12	extent	extent	NN
cord-015021-pol2qm74	2341	13	following	follow	VBG
cord-015021-pol2qm74	2341	14	exposure	exposure	NN
cord-015021-pol2qm74	2341	15	to	to	IN
cord-015021-pol2qm74	2341	16	NO	no	NN
cord-015021-pol2qm74	2341	17	.	.	.
cord-015021-pol2qm74	2342	1	However	however	RB
cord-015021-pol2qm74	2342	2	,	,	,
cord-015021-pol2qm74	2342	3	NO	NO	NNP
cord-015021-pol2qm74	2342	4	does	do	VBZ
cord-015021-pol2qm74	2342	5	inhibit	inhibit	VB
cord-015021-pol2qm74	2342	6	total	total	JJ
cord-015021-pol2qm74	2342	7	protein	protein	NN
cord-015021-pol2qm74	2342	8	synthesis	synthesis	NN
cord-015021-pol2qm74	2342	9	.	.	.
cord-015021-pol2qm74	2343	1	The	the	DT
cord-015021-pol2qm74	2343	2	exact	exact	JJ
cord-015021-pol2qm74	2343	3	biochemical	biochemical	JJ
cord-015021-pol2qm74	2343	4	mechanism	mechanism	NN
cord-015021-pol2qm74	2343	5	of	of	IN
cord-015021-pol2qm74	2343	6	this	this	DT
cord-015021-pol2qm74	2343	7	phenomenon	phenomenon	NN
cord-015021-pol2qm74	2343	8	has	have	VBZ
cord-015021-pol2qm74	2343	9	not	not	RB
cord-015021-pol2qm74	2343	10	been	be	VBN
cord-015021-pol2qm74	2343	11	uncovered	uncover	VBN
cord-015021-pol2qm74	2343	12	yet	yet	RB
cord-015021-pol2qm74	2343	13	,	,	,
cord-015021-pol2qm74	2343	14	but	but	CC
cord-015021-pol2qm74	2343	15	it	-PRON-	PRP
cord-015021-pol2qm74	2343	16	has	have	VBZ
cord-015021-pol2qm74	2343	17	been	be	VBN
cord-015021-pol2qm74	2343	18	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2343	19	for	for	IN
cord-015021-pol2qm74	2343	20	some	some	DT
cord-015021-pol2qm74	2343	21	specific	specific	JJ
cord-015021-pol2qm74	2343	22	proteins	protein	NNS
cord-015021-pol2qm74	2343	23	that	that	IN
cord-015021-pol2qm74	2343	24	their	-PRON-	PRP$
cord-015021-pol2qm74	2343	25	production	production	NN
cord-015021-pol2qm74	2343	26	is	be	VBZ
cord-015021-pol2qm74	2343	27	inhibited	inhibit	VBN
cord-015021-pol2qm74	2343	28	at	at	IN
cord-015021-pol2qm74	2343	29	a	a	DT
cord-015021-pol2qm74	2343	30	posttransscriptional	posttransscriptional	JJ
cord-015021-pol2qm74	2343	31	level	level	NN
cord-015021-pol2qm74	2343	32	.	.	.
cord-015021-pol2qm74	2344	1	As	as	IN
cord-015021-pol2qm74	2344	2	in	in	IN
cord-015021-pol2qm74	2344	3	many	many	JJ
cord-015021-pol2qm74	2344	4	other	other	JJ
cord-015021-pol2qm74	2344	5	celltypes	celltype	NNS
cord-015021-pol2qm74	2344	6	cGMP	cGMP	NNP
cord-015021-pol2qm74	2344	7	generation	generation	NN
cord-015021-pol2qm74	2344	8	is	be	VBZ
cord-015021-pol2qm74	2344	9	elevated	elevate	VBN
cord-015021-pol2qm74	2344	10	in	in	IN
cord-015021-pol2qm74	2344	11	HC	HC	NNP
cord-015021-pol2qm74	2344	12	by	by	IN
cord-015021-pol2qm74	2344	13	NO	no	DT
cord-015021-pol2qm74	2344	14	through	through	IN
cord-015021-pol2qm74	2344	15	activation	activation	NN
cord-015021-pol2qm74	2344	16	of	of	IN
cord-015021-pol2qm74	2344	17	the	the	DT
cord-015021-pol2qm74	2344	18	soluble	soluble	JJ
cord-015021-pol2qm74	2344	19	guanylate	guanylate	NN
cord-015021-pol2qm74	2344	20	cyclase	cyclase	NN
cord-015021-pol2qm74	2344	21	.	.	.
cord-015021-pol2qm74	2345	1	Cyclic	cyclic	JJ
cord-015021-pol2qm74	2345	2	GMP	GMP	NNP
cord-015021-pol2qm74	2345	3	may	may	MD
cord-015021-pol2qm74	2345	4	possibly	possibly	RB
cord-015021-pol2qm74	2345	5	exert	exert	VB
cord-015021-pol2qm74	2345	6	a	a	DT
cord-015021-pol2qm74	2345	7	plethora	plethora	NN
cord-015021-pol2qm74	2345	8	of	of	IN
cord-015021-pol2qm74	2345	9	metabolic	metabolic	JJ
cord-015021-pol2qm74	2345	10	functions	function	NNS
cord-015021-pol2qm74	2345	11	,	,	,
cord-015021-pol2qm74	2345	12	but	but	CC
cord-015021-pol2qm74	2345	13	it	-PRON-	PRP
cord-015021-pol2qm74	2345	14	is	be	VBZ
cord-015021-pol2qm74	2345	15	interesting	interesting	JJ
cord-015021-pol2qm74	2345	16	to	to	TO
cord-015021-pol2qm74	2345	17	note	note	VB
cord-015021-pol2qm74	2345	18	that	that	IN
cord-015021-pol2qm74	2345	19	most	most	JJS
cord-015021-pol2qm74	2345	20	of	of	IN
cord-015021-pol2qm74	2345	21	the	the	DT
cord-015021-pol2qm74	2345	22	cGMP	cGMP	NNP
cord-015021-pol2qm74	2345	23	seems	seem	VBZ
cord-015021-pol2qm74	2345	24	to	to	TO
cord-015021-pol2qm74	2345	25	be	be	VB
cord-015021-pol2qm74	2345	26	transported	transport	VBN
cord-015021-pol2qm74	2345	27	out	out	IN
cord-015021-pol2qm74	2345	28	of	of	IN
cord-015021-pol2qm74	2345	29	the	the	DT
cord-015021-pol2qm74	2345	30	cell	cell	NN
cord-015021-pol2qm74	2345	31	.	.	.
cord-015021-pol2qm74	2346	1	Some	some	DT
cord-015021-pol2qm74	2346	2	very	very	RB
cord-015021-pol2qm74	2346	3	specific	specific	JJ
cord-015021-pol2qm74	2346	4	effects	effect	NNS
cord-015021-pol2qm74	2346	5	of	of	IN
cord-015021-pol2qm74	2346	6	NO	no	NN
cord-015021-pol2qm74	2346	7	on	on	IN
cord-015021-pol2qm74	2346	8	HC	HC	NNP
cord-015021-pol2qm74	2346	9	metabolism	metabolism	NN
cord-015021-pol2qm74	2346	10	include	include	VBP
cord-015021-pol2qm74	2346	11	the	the	DT
cord-015021-pol2qm74	2346	12	inhibition	inhibition	NN
cord-015021-pol2qm74	2346	13	of	of	IN
cord-015021-pol2qm74	2346	14	the	the	DT
cord-015021-pol2qm74	2346	15	glyceraldehyde-3-phosphate	glyceraldehyde-3-phosphate	NNP
cord-015021-pol2qm74	2346	16	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	2346	17	(	(	-LRB-
cord-015021-pol2qm74	2346	18	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2346	19	)	)	-RRB-
cord-015021-pol2qm74	2346	20	and	and	CC
cord-015021-pol2qm74	2346	21	the	the	DT
cord-015021-pol2qm74	2346	22	cytochrome	cytochrome	NN
cord-015021-pol2qm74	2346	23	P450	p450	NN
cord-015021-pol2qm74	2346	24	(	(	-LRB-
cord-015021-pol2qm74	2346	25	CYP	CYP	NNP
cord-015021-pol2qm74	2346	26	)	)	-RRB-
cord-015021-pol2qm74	2346	27	enzymes	enzyme	NNS
cord-015021-pol2qm74	2346	28	.	.	.
cord-015021-pol2qm74	2347	1	Inhibition	inhibition	NN
cord-015021-pol2qm74	2347	2	of	of	IN
cord-015021-pol2qm74	2347	3	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2347	4	activity	activity	NN
cord-015021-pol2qm74	2347	5	is	be	VBZ
cord-015021-pol2qm74	2347	6	mediated	mediate	VBN
cord-015021-pol2qm74	2347	7	through	through	IN
cord-015021-pol2qm74	2347	8	nitrosylation	nitrosylation	NN
cord-015021-pol2qm74	2347	9	of	of	IN
cord-015021-pol2qm74	2347	10	critical	critical	JJ
cord-015021-pol2qm74	2347	11	domains	domain	NNS
cord-015021-pol2qm74	2347	12	of	of	IN
cord-015021-pol2qm74	2347	13	the	the	DT
cord-015021-pol2qm74	2347	14	enzymes	enzyme	NNS
cord-015021-pol2qm74	2347	15	by	by	IN
cord-015021-pol2qm74	2347	16	NO	no	DT
cord-015021-pol2qm74	2347	17	which	which	WDT
cord-015021-pol2qm74	2347	18	enhances	enhance	VBZ
cord-015021-pol2qm74	2347	19	auto	auto	NN
cord-015021-pol2qm74	2347	20	-	-	HYPH
cord-015021-pol2qm74	2347	21	ADPribosylation	adpribosylation	NN
cord-015021-pol2qm74	2347	22	.	.	.
cord-015021-pol2qm74	2348	1	This	this	DT
cord-015021-pol2qm74	2348	2	effect	effect	NN
cord-015021-pol2qm74	2348	3	on	on	IN
cord-015021-pol2qm74	2348	4	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2348	5	activity	activity	NN
cord-015021-pol2qm74	2348	6	might	may	MD
cord-015021-pol2qm74	2348	7	be	be	VB
cord-015021-pol2qm74	2348	8	responsible	responsible	JJ
cord-015021-pol2qm74	2348	9	for	for	IN
cord-015021-pol2qm74	2348	10	the	the	DT
cord-015021-pol2qm74	2348	11	inhibition	inhibition	NN
cord-015021-pol2qm74	2348	12	of	of	IN
cord-015021-pol2qm74	2348	13	gluconeogenesis	gluconeogenesis	NN
cord-015021-pol2qm74	2348	14	by	by	IN
cord-015021-pol2qm74	2348	15	NO	NO	NNP
cord-015021-pol2qm74	2348	16	,	,	,
cord-015021-pol2qm74	2348	17	which	which	WDT
cord-015021-pol2qm74	2348	18	has	have	VBZ
cord-015021-pol2qm74	2348	19	been	be	VBN
cord-015021-pol2qm74	2348	20	described	describe	VBN
cord-015021-pol2qm74	2348	21	recently	recently	RB
cord-015021-pol2qm74	2348	22	.	.	.
cord-015021-pol2qm74	2349	1	Finally	finally	RB
cord-015021-pol2qm74	2349	2	,	,	,
cord-015021-pol2qm74	2349	3	NO	no	RB
cord-015021-pol2qm74	2349	4	-	-	HYPH
cord-015021-pol2qm74	2349	5	mediated	mediate	VBN
cord-015021-pol2qm74	2349	6	inhibition	inhibition	NN
cord-015021-pol2qm74	2349	7	of	of	IN
cord-015021-pol2qm74	2349	8	CYPs	cyps	NN
cord-015021-pol2qm74	2349	9	may	may	MD
cord-015021-pol2qm74	2349	10	help	help	VB
cord-015021-pol2qm74	2349	11	to	to	TO
cord-015021-pol2qm74	2349	12	explain	explain	VB
cord-015021-pol2qm74	2349	13	the	the	DT
cord-015021-pol2qm74	2349	14	suppression	suppression	NN
cord-015021-pol2qm74	2349	15	of	of	IN
cord-015021-pol2qm74	2349	16	hiotransformation	hiotransformation	NN
cord-015021-pol2qm74	2349	17	processes	process	NNS
cord-015021-pol2qm74	2349	18	which	which	WDT
cord-015021-pol2qm74	2349	19	is	be	VBZ
cord-015021-pol2qm74	2349	20	a	a	DT
cord-015021-pol2qm74	2349	21	characteristic	characteristic	JJ
cord-015021-pol2qm74	2349	22	featur,'~	featur,'~	NN
cord-015021-pol2qm74	2349	23	r	r	NN
cord-015021-pol2qm74	2350	1	~	~	NFP
cord-015021-pol2qm74	2350	2	"	"	``
cord-015021-pol2qm74	2350	3	~flamed	~flame	VBN
cord-015021-pol2qm74	2351	1	liver	liver	NN
cord-015021-pol2qm74	2351	2	.	.	.
cord-015021-pol2qm74	2352	1	Nitric	nitric	NN
cord-015021-pol2qm74	2352	2	oxide	oxide	NN
cord-015021-pol2qm74	2352	3	(	(	-LRB-
cord-015021-pol2qm74	2352	4	NO	no	UH
cord-015021-pol2qm74	2352	5	)	)	-RRB-
cord-015021-pol2qm74	2352	6	is	be	VBZ
cord-015021-pol2qm74	2352	7	an	an	DT
cord-015021-pol2qm74	2352	8	endogenous	endogenous	JJ
cord-015021-pol2qm74	2352	9	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2352	10	of	of	IN
cord-015021-pol2qm74	2352	11	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	2352	12	leukocyte	leukocyte	NN
cord-015021-pol2qm74	2352	13	(	(	-LRB-
cord-015021-pol2qm74	2352	14	PMN	PMN	NNP
cord-015021-pol2qm74	2352	15	)	)	-RRB-
cord-015021-pol2qm74	2352	16	adhesion	adhesion	NN
cord-015021-pol2qm74	2352	17	which	which	WDT
cord-015021-pol2qm74	2352	18	limits	limit	VBZ
cord-015021-pol2qm74	2352	19	PMN	pmn	NN
cord-015021-pol2qm74	2352	20	-	-	HYPH
cord-015021-pol2qm74	2352	21	endothelial	endothelial	JJ
cord-015021-pol2qm74	2352	22	cell	cell	NN
cord-015021-pol2qm74	2352	23	interactions	interaction	NNS
cord-015021-pol2qm74	2352	24	under	under	IN
cord-015021-pol2qm74	2352	25	normal	normal	JJ
cord-015021-pol2qm74	2352	26	conditions	condition	NNS
cord-015021-pol2qm74	2352	27	.	.	.
cord-015021-pol2qm74	2353	1	We	-PRON-	PRP
cord-015021-pol2qm74	2353	2	have	have	VBP
cord-015021-pol2qm74	2353	3	previously	previously	RB
cord-015021-pol2qm74	2353	4	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2353	5	that	that	IN
cord-015021-pol2qm74	2353	6	following	follow	VBG
cord-015021-pol2qm74	2353	7	ischemia	ischemia	NN
cord-015021-pol2qm74	2353	8	,	,	,
cord-015021-pol2qm74	2353	9	NO	no	DT
cord-015021-pol2qm74	2353	10	production	production	NN
cord-015021-pol2qm74	2353	11	by	by	IN
cord-015021-pol2qm74	2353	12	the	the	DT
cord-015021-pol2qm74	2353	13	vascular	vascular	JJ
cord-015021-pol2qm74	2353	14	endothelinm	endothelinm	NNP
cord-015021-pol2qm74	2353	15	is	be	VBZ
cord-015021-pol2qm74	2353	16	dramatically	dramatically	RB
cord-015021-pol2qm74	2353	17	reduced	reduce	VBN
cord-015021-pol2qm74	2353	18	.	.	.
cord-015021-pol2qm74	2354	1	Accordingly	accordingly	RB
cord-015021-pol2qm74	2354	2	,	,	,
cord-015021-pol2qm74	2354	3	we	-PRON-	PRP
cord-015021-pol2qm74	2354	4	investigated	investigate	VBD
cord-015021-pol2qm74	2354	5	the	the	DT
cord-015021-pol2qm74	2354	6	effects	effect	NNS
cord-015021-pol2qm74	2354	7	of	of	IN
cord-015021-pol2qm74	2354	8	NO	NO	NNP
cord-015021-pol2qm74	2354	9	-	-	HYPH
cord-015021-pol2qm74	2354	10	Donors	donor	NNS
cord-015021-pol2qm74	2354	11	on	on	IN
cord-015021-pol2qm74	2354	12	PMN	PMN	NNP
cord-015021-pol2qm74	2354	13	accumulation	accumulation	NN
cord-015021-pol2qm74	2354	14	and	and	CC
cord-015021-pol2qm74	2354	15	tissue	tissue	NN
cord-015021-pol2qm74	2354	16	injury	injury	NN
cord-015021-pol2qm74	2354	17	following	follow	VBG
cord-015021-pol2qm74	2354	18	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	2354	19	shock	shock	NN
cord-015021-pol2qm74	2354	20	and	and	CC
cord-015021-pol2qm74	2354	21	ischemia	ischemia	NN
cord-015021-pol2qm74	2354	22	.	.	.
cord-015021-pol2qm74	2355	1	Hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	2355	2	shock	shock	NN
cord-015021-pol2qm74	2355	3	was	be	VBD
cord-015021-pol2qm74	2355	4	induced	induce	VBN
cord-015021-pol2qm74	2355	5	in	in	IN
cord-015021-pol2qm74	2355	6	anesthetized	anesthetized	JJ
cord-015021-pol2qm74	2355	7	rats	rat	NNS
cord-015021-pol2qm74	2355	8	by	by	IN
cord-015021-pol2qm74	2355	9	bleeding	bleed	VBG
cord-015021-pol2qm74	2355	10	to	to	IN
cord-015021-pol2qm74	2355	11	35	35	CD
cord-015021-pol2qm74	2355	12	mmHg	mmHg	NNS
cord-015021-pol2qm74	2355	13	for	for	IN
cord-015021-pol2qm74	2355	14	3	3	CD
cord-015021-pol2qm74	2355	15	hours	hour	NNS
cord-015021-pol2qm74	2355	16	followed	follow	VBN
cord-015021-pol2qm74	2355	17	by	by	IN
cord-015021-pol2qm74	2355	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2355	19	.	.	.
cord-015021-pol2qm74	2356	1	Segments	segment	NNS
cord-015021-pol2qm74	2356	2	of	of	IN
cord-015021-pol2qm74	2356	3	superior	superior	JJ
cord-015021-pol2qm74	2356	4	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	2356	5	artery	artery	NN
cord-015021-pol2qm74	2356	6	(	(	-LRB-
cord-015021-pol2qm74	2356	7	SMA	SMA	NNP
cord-015021-pol2qm74	2356	8	)	)	-RRB-
cord-015021-pol2qm74	2356	9	were	be	VBD
cord-015021-pol2qm74	2356	10	isolated	isolate	VBN
cord-015021-pol2qm74	2356	11	and	and	CC
cord-015021-pol2qm74	2356	12	suspended	suspend	VBN
cord-015021-pol2qm74	2356	13	in	in	IN
cord-015021-pol2qm74	2356	14	organ	organ	NN
cord-015021-pol2qm74	2356	15	baths	bath	NNS
cord-015021-pol2qm74	2356	16	.	.	.
cord-015021-pol2qm74	2357	1	In	in	IN
cord-015021-pol2qm74	2357	2	rats	rat	NNS
cord-015021-pol2qm74	2357	3	receiving	receive	VBG
cord-015021-pol2qm74	2357	4	saline	saline	JJ
cord-015021-pol2qm74	2357	5	SMA	sma	JJ
cord-015021-pol2qm74	2357	6	relaxation	relaxation	NN
cord-015021-pol2qm74	2357	7	to	to	IN
cord-015021-pol2qm74	2357	8	acetylcholine	acetylcholine	NN
cord-015021-pol2qm74	2357	9	(	(	-LRB-
cord-015021-pol2qm74	2357	10	ACh	ACh	NNP
cord-015021-pol2qm74	2357	11	,	,	,
cord-015021-pol2qm74	2357	12	100	100	CD
cord-015021-pol2qm74	2357	13	nM	nm	NN
cord-015021-pol2qm74	2357	14	)	)	-RRB-
cord-015021-pol2qm74	2357	15	was	be	VBD
cord-015021-pol2qm74	2357	16	reduced	reduce	VBN
cord-015021-pol2qm74	2357	17	by	by	IN
cord-015021-pol2qm74	2357	18	80	80	CD
cord-015021-pol2qm74	2357	19	%	%	NN
cord-015021-pol2qm74	2357	20	compared	compare	VBN
cord-015021-pol2qm74	2357	21	to	to	TO
cord-015021-pol2qm74	2357	22	control	control	VB
cord-015021-pol2qm74	2357	23	SMA	sma	JJ
cord-015021-pol2qm74	2357	24	segments	segment	NNS
cord-015021-pol2qm74	2357	25	(	(	-LRB-
cord-015021-pol2qm74	2357	26	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	2357	27	)	)	-RRB-
cord-015021-pol2qm74	2357	28	while	while	IN
cord-015021-pol2qm74	2357	29	relaxation	relaxation	NN
cord-015021-pol2qm74	2357	30	to	to	IN
cord-015021-pol2qm74	2357	31	sodium	sodium	NN
cord-015021-pol2qm74	2357	32	nitrite	nitrite	NN
cord-015021-pol2qm74	2357	33	(	(	-LRB-
cord-015021-pol2qm74	2357	34	100	100	CD
cord-015021-pol2qm74	2357	35	gM	gm	NN
cord-015021-pol2qm74	2357	36	)	)	-RRB-
cord-015021-pol2qm74	2357	37	was	be	VBD
cord-015021-pol2qm74	2357	38	unaffected	unaffected	JJ
cord-015021-pol2qm74	2357	39	.	.	.
cord-015021-pol2qm74	2358	1	In	in	IN
cord-015021-pol2qm74	2358	2	addition	addition	NN
cord-015021-pol2qm74	2358	3	,	,	,
cord-015021-pol2qm74	2358	4	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	2358	5	tissue	tissue	NN
cord-015021-pol2qm74	2358	6	PMN	PMN	NNP
cord-015021-pol2qm74	2358	7	accumulation	accumulation	NN
cord-015021-pol2qm74	2358	8	as	as	IN
cord-015021-pol2qm74	2358	9	determined	determine	VBN
cord-015021-pol2qm74	2358	10	by	by	IN
cord-015021-pol2qm74	2358	11	myeloperoxidase	myeloperoxidase	NNP
cord-015021-pol2qm74	2358	12	(	(	-LRB-
cord-015021-pol2qm74	2358	13	MPO	MPO	NNP
cord-015021-pol2qm74	2358	14	)	)	-RRB-
cord-015021-pol2qm74	2358	15	activity	activity	NN
cord-015021-pol2qm74	2358	16	was	be	VBD
cord-015021-pol2qm74	2358	17	significantly	significantly	RB
cord-015021-pol2qm74	2358	18	elevated	elevate	VBN
cord-015021-pol2qm74	2358	19	compared	compare	VBN
cord-015021-pol2qm74	2358	20	to	to	IN
cord-015021-pol2qm74	2358	21	controls	control	NNS
cord-015021-pol2qm74	2358	22	(	(	-LRB-
cord-015021-pol2qm74	2358	23	p<0.0l	p<0.0l	NNP
cord-015021-pol2qm74	2358	24	)	)	-RRB-
cord-015021-pol2qm74	2358	25	.	.	.
cord-015021-pol2qm74	2359	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	2359	2	,	,	,
cord-015021-pol2qm74	2359	3	treatment	treatment	NN
cord-015021-pol2qm74	2359	4	with	with	IN
cord-015021-pol2qm74	2359	5	the	the	DT
cord-015021-pol2qm74	2359	6	NO	no	RB
cord-015021-pol2qm74	2359	7	-	-	HYPH
cord-015021-pol2qm74	2359	8	donating	donate	VBG
cord-015021-pol2qm74	2359	9	agent	agent	NN
cord-015021-pol2qm74	2359	10	,	,	,
cord-015021-pol2qm74	2359	11	S	S	NNP
cord-015021-pol2qm74	2359	12	-	-	HYPH
cord-015021-pol2qm74	2359	13	nitroso	nitroso	NNP
cord-015021-pol2qm74	2359	14	-	-	HYPH
cord-015021-pol2qm74	2359	15	N	N	NNP
cord-015021-pol2qm74	2359	16	-	-	HYPH
cord-015021-pol2qm74	2359	17	acetylpenicillamine	acetylpenicillamine	NNP
cord-015021-pol2qm74	2359	18	(	(	-LRB-
cord-015021-pol2qm74	2359	19	SNAP	snap	VB
cord-015021-pol2qm74	2359	20	)	)	-RRB-
cord-015021-pol2qm74	2359	21	significantly	significantly	RB
cord-015021-pol2qm74	2359	22	preserved	preserve	VBN
cord-015021-pol2qm74	2359	23	SMA	sma	JJ
cord-015021-pol2qm74	2359	24	relaxation	relaxation	NN
cord-015021-pol2qm74	2359	25	(	(	-LRB-
cord-015021-pol2qm74	2359	26	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	2359	27	)	)	-RRB-
cord-015021-pol2qm74	2359	28	,	,	,
cord-015021-pol2qm74	2359	29	attenuated	attenuated	JJ
cord-015021-pol2qm74	2359	30	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	2359	31	MPO	MPO	NNP
cord-015021-pol2qm74	2359	32	(	(	-LRB-
cord-015021-pol2qm74	2359	33	p<0.05	p<0.05	CD
cord-015021-pol2qm74	2359	34	)	)	-RRB-
cord-015021-pol2qm74	2359	35	activity	activity	NN
cord-015021-pol2qm74	2359	36	,	,	,
cord-015021-pol2qm74	2359	37	and	and	CC
cord-015021-pol2qm74	2359	38	significantly	significantly	RB
cord-015021-pol2qm74	2359	39	improved	improve	VBN
cord-015021-pol2qm74	2359	40	survival	survival	NN
cord-015021-pol2qm74	2359	41	compared	compare	VBN
cord-015021-pol2qm74	2359	42	to	to	IN
cord-015021-pol2qm74	2359	43	saline	saline	NN
cord-015021-pol2qm74	2359	44	vehicle	vehicle	NN
cord-015021-pol2qm74	2359	45	.	.	.
cord-015021-pol2qm74	2360	1	In	in	IN
cord-015021-pol2qm74	2360	2	anesthetized	anesthetized	JJ
cord-015021-pol2qm74	2360	3	,	,	,
cord-015021-pol2qm74	2360	4	open	open	JJ
cord-015021-pol2qm74	2360	5	-	-	HYPH
cord-015021-pol2qm74	2360	6	chest	chest	NN
cord-015021-pol2qm74	2360	7	dogs	dog	NNS
cord-015021-pol2qm74	2360	8	we	-PRON-	PRP
cord-015021-pol2qm74	2360	9	investigated	investigate	VBD
cord-015021-pol2qm74	2360	10	the	the	DT
cord-015021-pol2qm74	2360	11	cardioprotective	cardioprotective	JJ
cord-015021-pol2qm74	2360	12	actions	action	NNS
cord-015021-pol2qm74	2360	13	of	of	IN
cord-015021-pol2qm74	2360	14	a	a	DT
cord-015021-pol2qm74	2360	15	novel	novel	JJ
cord-015021-pol2qm74	2360	16	NO	NO	NNP
cord-015021-pol2qm74	2360	17	-	-	HYPH
cord-015021-pol2qm74	2360	18	Donor	Donor	NNP
cord-015021-pol2qm74	2360	19	,	,	,
cord-015021-pol2qm74	2360	20	SPM-5185	SPM-5185	NNP
cord-015021-pol2qm74	2360	21	(	(	-LRB-
cord-015021-pol2qm74	2360	22	Schwarz	Schwarz	NNP
cord-015021-pol2qm74	2360	23	Pharma	Pharma	NNP
cord-015021-pol2qm74	2360	24	)	)	-RRB-
cord-015021-pol2qm74	2360	25	,	,	,
cord-015021-pol2qm74	2360	26	following	follow	VBG
cord-015021-pol2qm74	2360	27	regional	regional	JJ
cord-015021-pol2qm74	2360	28	myocardial	myocardial	JJ
cord-015021-pol2qm74	2360	29	ischemia	ischemia	NN
cord-015021-pol2qm74	2360	30	(	(	-LRB-
cord-015021-pol2qm74	2360	31	1	1	CD
cord-015021-pol2qm74	2360	32	hour	hour	NN
cord-015021-pol2qm74	2360	33	)	)	-RRB-
cord-015021-pol2qm74	2360	34	and	and	CC
cord-015021-pol2qm74	2360	35	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2360	36	(	(	-LRB-
cord-015021-pol2qm74	2360	37	4.5	4.5	CD
cord-015021-pol2qm74	2360	38	hours	hour	NNS
cord-015021-pol2qm74	2360	39	)	)	-RRB-
cord-015021-pol2qm74	2360	40	.	.	.
cord-015021-pol2qm74	2361	1	Treatment	treatment	NN
cord-015021-pol2qm74	2361	2	with	with	IN
cord-015021-pol2qm74	2361	3	SPM-5185	SPM-5185	NNPS
cord-015021-pol2qm74	2361	4	(	(	-LRB-
cord-015021-pol2qm74	2361	5	500	500	CD
cord-015021-pol2qm74	2361	6	riM	rim	CD
cord-015021-pol2qm74	2361	7	)	)	-RRB-
cord-015021-pol2qm74	2361	8	significantly	significantly	RB
cord-015021-pol2qm74	2361	9	reduced	reduce	VBN
cord-015021-pol2qm74	2361	10	myocardial	myocardial	JJ
cord-015021-pol2qm74	2361	11	necrosis	necrosis	NN
cord-015021-pol2qm74	2361	12	by	by	IN
cord-015021-pol2qm74	2361	13	70	70	CD
cord-015021-pol2qm74	2361	14	%	%	NN
cord-015021-pol2qm74	2361	15	(	(	-LRB-
cord-015021-pol2qm74	2361	16	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	2361	17	)	)	-RRB-
cord-015021-pol2qm74	2361	18	compared	compare	VBN
cord-015021-pol2qm74	2361	19	to	to	IN
cord-015021-pol2qm74	2361	20	an	an	DT
cord-015021-pol2qm74	2361	21	NO	no	RB
cord-015021-pol2qm74	2361	22	-	-	HYPH
cord-015021-pol2qm74	2361	23	deficient	deficient	JJ
cord-015021-pol2qm74	2361	24	analog	analog	NN
cord-015021-pol2qm74	2361	25	of	of	IN
cord-015021-pol2qm74	2361	26	SPM-5185	SPM-5185	NNP
cord-015021-pol2qm74	2361	27	,	,	,
cord-015021-pol2qm74	2361	28	SPM-5267	SPM-5267	NNP
cord-015021-pol2qm74	2361	29	.	.	.
cord-015021-pol2qm74	2362	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2362	2	,	,	,
cord-015021-pol2qm74	2362	3	MPO	MPO	NNP
cord-015021-pol2qm74	2362	4	activity	activity	NN
cord-015021-pol2qm74	2362	5	within	within	IN
cord-015021-pol2qm74	2362	6	the	the	DT
cord-015021-pol2qm74	2362	7	ischemic	ischemic	JJ
cord-015021-pol2qm74	2362	8	-	-	HYPH
cord-015021-pol2qm74	2362	9	reperfused	reperfused	JJ
cord-015021-pol2qm74	2362	10	zone	zone	NN
cord-015021-pol2qm74	2362	11	was	be	VBD
cord-015021-pol2qm74	2362	12	also	also	RB
cord-015021-pol2qm74	2362	13	significantly	significantly	RB
cord-015021-pol2qm74	2362	14	(	(	-LRB-
cord-015021-pol2qm74	2362	15	p<0.01	p<0.01	JJ
cord-015021-pol2qm74	2362	16	)	)	-RRB-
cord-015021-pol2qm74	2362	17	reduced	reduce	VBN
cord-015021-pol2qm74	2362	18	following	follow	VBG
cord-015021-pol2qm74	2362	19	treatment	treatment	NN
cord-015021-pol2qm74	2362	20	with	with	IN
cord-015021-pol2qm74	2362	21	SPM-5185	SPM-5185	NNPS
cord-015021-pol2qm74	2362	22	compared	compare	VBN
cord-015021-pol2qm74	2362	23	to	to	IN
cord-015021-pol2qm74	2362	24	SPM-5267	SPM-5267	NNP
cord-015021-pol2qm74	2362	25	(	(	-LRB-
cord-015021-pol2qm74	2362	26	1.6	1.6	CD
cord-015021-pol2qm74	2362	27	+	+	SYM
cord-015021-pol2qm74	2362	28	0.5	0.5	CD
cord-015021-pol2qm74	2362	29	vs.	vs.	CC
cord-015021-pol2qm74	2362	30	3.8	3.8	CD
cord-015021-pol2qm74	2362	31	+	+	SYM
cord-015021-pol2qm74	2362	32	0.3	0.3	CD
cord-015021-pol2qm74	2362	33	U/100	U/100	NNS
cord-015021-pol2qm74	2362	34	mg	mg	CD
cord-015021-pol2qm74	2362	35	tissue	tissue	NN
cord-015021-pol2qm74	2362	36	)	)	-RRB-
cord-015021-pol2qm74	2362	37	.	.	.
cord-015021-pol2qm74	2363	1	These	these	DT
cord-015021-pol2qm74	2363	2	data	datum	NNS
cord-015021-pol2qm74	2363	3	strongly	strongly	RB
cord-015021-pol2qm74	2363	4	suggest	suggest	VBP
cord-015021-pol2qm74	2363	5	that	that	IN
cord-015021-pol2qm74	2363	6	NO	no	DT
cord-015021-pol2qm74	2363	7	is	be	VBZ
cord-015021-pol2qm74	2363	8	a	a	DT
cord-015021-pol2qm74	2363	9	potent	potent	JJ
cord-015021-pol2qm74	2363	10	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2363	11	of	of	IN
cord-015021-pol2qm74	2363	12	PMN	pmn	NN
cord-015021-pol2qm74	2363	13	-	-	HYPH
cord-015021-pol2qm74	2363	14	mediated	mediate	VBN
cord-015021-pol2qm74	2363	15	tissue	tissue	NN
cord-015021-pol2qm74	2363	16	injury	injury	NN
cord-015021-pol2qm74	2363	17	following	follow	VBG
cord-015021-pol2qm74	2363	18	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	2363	19	shock	shock	NN
cord-015021-pol2qm74	2363	20	as	as	RB
cord-015021-pol2qm74	2363	21	well	well	RB
cord-015021-pol2qm74	2363	22	as	as	IN
cord-015021-pol2qm74	2363	23	in	in	IN
cord-015021-pol2qm74	2363	24	acute	acute	JJ
cord-015021-pol2qm74	2363	25	myocardial	myocardial	JJ
cord-015021-pol2qm74	2363	26	ischemia	ischemia	NN
cord-015021-pol2qm74	2363	27	-	-	HYPH
cord-015021-pol2qm74	2363	28	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2363	29	injury	injury	NN
cord-015021-pol2qm74	2363	30	.	.	.
cord-015021-pol2qm74	2364	1	Overproduction	overproduction	NN
cord-015021-pol2qm74	2364	2	of	of	IN
cord-015021-pol2qm74	2364	3	nitdc	nitdc	NNS
cord-015021-pol2qm74	2364	4	oxide	oxide	NN
cord-015021-pol2qm74	2364	5	(	(	-LRB-
cord-015021-pol2qm74	2364	6	NO	no	UH
cord-015021-pol2qm74	2364	7	'	'	''
cord-015021-pol2qm74	2364	8	)	)	-RRB-
cord-015021-pol2qm74	2364	9	may	may	MD
cord-015021-pol2qm74	2364	10	contribute	contribute	VB
cord-015021-pol2qm74	2364	11	to	to	IN
cord-015021-pol2qm74	2364	12	sepsis	sepsis	NN
cord-015021-pol2qm74	2364	13	-	-	HYPH
cord-015021-pol2qm74	2364	14	induced	induce	VBN
cord-015021-pol2qm74	2364	15	hypotension	hypotension	NN
cord-015021-pol2qm74	2364	16	.	.	.
cord-015021-pol2qm74	2365	1	During	during	IN
cord-015021-pol2qm74	2365	2	septic	septic	JJ
cord-015021-pol2qm74	2365	3	shock	shock	NN
cord-015021-pol2qm74	2365	4	,	,	,
cord-015021-pol2qm74	2365	5	excess	excess	JJ
cord-015021-pol2qm74	2365	6	NO	no	NN
cord-015021-pol2qm74	2365	7	"	"	''
cord-015021-pol2qm74	2365	8	is	be	VBZ
cord-015021-pol2qm74	2365	9	produced	produce	VBN
cord-015021-pol2qm74	2365	10	by	by	IN
cord-015021-pol2qm74	2365	11	an	an	DT
cord-015021-pol2qm74	2365	12	isoform	isoform	NN
cord-015021-pol2qm74	2365	13	of	of	IN
cord-015021-pol2qm74	2365	14	nitric	nitric	JJ
cord-015021-pol2qm74	2365	15	oxide	oxide	NN
cord-015021-pol2qm74	2365	16	synthase	synthase	NN
cord-015021-pol2qm74	2365	17	(	(	-LRB-
cord-015021-pol2qm74	2365	18	NOS	NOS	NNP
cord-015021-pol2qm74	2365	19	)	)	-RRB-
cord-015021-pol2qm74	2365	20	which	which	WDT
cord-015021-pol2qm74	2365	21	is	be	VBZ
cord-015021-pol2qm74	2365	22	induced	induce	VBN
cord-015021-pol2qm74	2365	23	by	by	IN
cord-015021-pol2qm74	2365	24	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2365	25	mediators	mediator	NNS
cord-015021-pol2qm74	2365	26	.	.	.
cord-015021-pol2qm74	2366	1	Nonselective	nonselective	JJ
cord-015021-pol2qm74	2366	2	NOS	NOS	NNP
cord-015021-pol2qm74	2366	3	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	2366	4	have	have	VBP
cord-015021-pol2qm74	2366	5	been	be	VBN
cord-015021-pol2qm74	2366	6	proposed	propose	VBN
cord-015021-pol2qm74	2366	7	as	as	IN
cord-015021-pol2qm74	2366	8	a	a	DT
cord-015021-pol2qm74	2366	9	new	new	JJ
cord-015021-pol2qm74	2366	10	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	2366	11	approach	approach	NN
cord-015021-pol2qm74	2366	12	to	to	IN
cord-015021-pol2qm74	2366	13	treating	treat	VBG
cord-015021-pol2qm74	2366	14	hypotension	hypotension	NN
cord-015021-pol2qm74	2366	15	in	in	IN
cord-015021-pol2qm74	2366	16	septic	septic	JJ
cord-015021-pol2qm74	2366	17	shock	shock	NN
cord-015021-pol2qm74	2366	18	.	.	.
cord-015021-pol2qm74	2367	1	We	-PRON-	PRP
cord-015021-pol2qm74	2367	2	studied	study	VBD
cord-015021-pol2qm74	2367	3	the	the	DT
cord-015021-pol2qm74	2367	4	differential	differential	JJ
cord-015021-pol2qm74	2367	5	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	2367	6	effects	effect	NNS
cord-015021-pol2qm74	2367	7	of	of	IN
cord-015021-pol2qm74	2367	8	N~-methyI	N~-methyI	NNP
cord-015021-pol2qm74	2367	9	-	-	HYPH
cord-015021-pol2qm74	2367	10	L	l	NN
cord-015021-pol2qm74	2367	11	-	-	HYPH
cord-015021-pol2qm74	2367	12	arginine	arginine	NN
cord-015021-pol2qm74	2367	13	(	(	-LRB-
cord-015021-pol2qm74	2367	14	L	L	NNP
cord-015021-pol2qm74	2367	15	-	-	HYPH
cord-015021-pol2qm74	2367	16	NMA	NMA	NNP
cord-015021-pol2qm74	2367	17	)	)	-RRB-
cord-015021-pol2qm74	2367	18	,	,	,
cord-015021-pol2qm74	2367	19	a	a	DT
cord-015021-pol2qm74	2367	20	NOS	NOS	NNP
cord-015021-pol2qm74	2367	21	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2367	22	,	,	,
cord-015021-pol2qm74	2367	23	in	in	IN
cord-015021-pol2qm74	2367	24	normal	normal	JJ
cord-015021-pol2qm74	2367	25	canines	canine	NNS
cord-015021-pol2qm74	2367	26	versus	versus	IN
cord-015021-pol2qm74	2367	27	those	those	DT
cord-015021-pol2qm74	2367	28	challenged	challenge	VBN
cord-015021-pol2qm74	2367	29	with	with	IN
cord-015021-pol2qm74	2367	30	endotexin	endotexin	NNP
cord-015021-pol2qm74	2367	31	(	(	-LRB-
cord-015021-pol2qm74	2367	32	LPS	LPS	NNP
cord-015021-pol2qm74	2367	33	)	)	-RRB-
cord-015021-pol2qm74	2367	34	and	and	CC
cord-015021-pol2qm74	2367	35	compared	compare	VBD
cord-015021-pol2qm74	2367	36	the	the	DT
cord-015021-pol2qm74	2367	37	activity	activity	NN
cord-015021-pol2qm74	2367	38	of	of	IN
cord-015021-pol2qm74	2367	39	this	this	DT
cord-015021-pol2qm74	2367	40	drug	drug	NN
cord-015021-pol2qm74	2367	41	across	across	IN
cord-015021-pol2qm74	2367	42	the	the	DT
cord-015021-pol2qm74	2367	43	venous	venous	JJ
cord-015021-pol2qm74	2367	44	,	,	,
cord-015021-pol2qm74	2367	45	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2367	46	and	and	CC
cord-015021-pol2qm74	2367	47	systemic	systemic	JJ
cord-015021-pol2qm74	2367	48	vascular	vascular	JJ
cord-015021-pol2qm74	2367	49	beds	bed	NNS
cord-015021-pol2qm74	2367	50	.	.	.
cord-015021-pol2qm74	2368	1	Awake	awake	JJ
cord-015021-pol2qm74	2368	2	canines	canine	NNS
cord-015021-pol2qm74	2368	3	were	be	VBD
cord-015021-pol2qm74	2368	4	challenged	challenge	VBN
cord-015021-pol2qm74	2368	5	with	with	IN
cord-015021-pol2qm74	2368	6	LPS	LPS	NNP
cord-015021-pol2qm74	2368	7	(	(	-LRB-
cord-015021-pol2qm74	2368	8	0	0	NFP
cord-015021-pol2qm74	2368	9	mg	mg	NNP
cord-015021-pol2qm74	2368	10	/	/	SYM
cord-015021-pol2qm74	2368	11	kg	kg	NNP
cord-015021-pol2qm74	2368	12	,	,	,
cord-015021-pol2qm74	2368	13	n=15:8	n=15:8	NNP
cord-015021-pol2qm74	2368	14	mg	mg	NNP
cord-015021-pol2qm74	2368	15	/	/	SYM
cord-015021-pol2qm74	2368	16	kg	kg	NNP
cord-015021-pol2qm74	2368	17	,	,	,
cord-015021-pol2qm74	2368	18	n=21	n=21	NN
cord-015021-pol2qm74	2368	19	;	;	:
cord-015021-pol2qm74	2368	20	or	or	CC
cord-015021-pol2qm74	2368	21	16	16	CD
cord-015021-pol2qm74	2368	22	mg	mg	NNP
cord-015021-pol2qm74	2368	23	/	/	SYM
cord-015021-pol2qm74	2368	24	kg	kg	NNP
cord-015021-pol2qm74	2368	25	,	,	,
cord-015021-pol2qm74	2368	26	n=30	n=30	NNP
cord-015021-pol2qm74	2368	27	)	)	-RRB-
cord-015021-pol2qm74	2368	28	and	and	CC
cord-015021-pol2qm74	2368	29	treated	treat	VBN
cord-015021-pol2qm74	2368	30	with	with	IN
cord-015021-pol2qm74	2368	31	L	L	NNP
cord-015021-pol2qm74	2368	32	-	-	HYPH
cord-015021-pol2qm74	2368	33	NMA	NMA	NNP
cord-015021-pol2qm74	2368	34	(	(	-LRB-
cord-015021-pol2qm74	2368	35	0	0	NFP
cord-015021-pol2qm74	2368	36	,	,	,
cord-015021-pol2qm74	2368	37	1,2	1,2	CD
cord-015021-pol2qm74	2368	38	,	,	,
cord-015021-pol2qm74	2368	39	4,10	4,10	CD
cord-015021-pol2qm74	2368	40	mg	mg	NNP
cord-015021-pol2qm74	2368	41	/	/	SYM
cord-015021-pol2qm74	2368	42	kg	kg	NNP
cord-015021-pol2qm74	2368	43	/	/	SYM
cord-015021-pol2qm74	2368	44	hr	hr	NN
cord-015021-pol2qm74	2368	45	)	)	-RRB-
cord-015021-pol2qm74	2368	46	for	for	IN
cord-015021-pol2qm74	2368	47	22	22	CD
cord-015021-pol2qm74	2368	48	hours	hour	NNS
cord-015021-pol2qm74	2368	49	following	follow	VBG
cord-015021-pol2qm74	2368	50	a	a	DT
cord-015021-pol2qm74	2368	51	0	0	CD
cord-015021-pol2qm74	2368	52	,	,	,
cord-015021-pol2qm74	2368	53	10	10	CD
cord-015021-pol2qm74	2368	54	,	,	,
cord-015021-pol2qm74	2368	55	or40	or40	NNP
cord-015021-pol2qm74	2368	56	mg	mg	NNP
cord-015021-pol2qm74	2368	57	/	/	SYM
cord-015021-pol2qm74	2368	58	kg	kg	NNP
cord-015021-pol2qm74	2368	59	loading	loading	NN
cord-015021-pol2qm74	2368	60	dose	dose	NN
cord-015021-pol2qm74	2368	61	.	.	.
cord-015021-pol2qm74	2369	1	Animals	animal	NNS
cord-015021-pol2qm74	2369	2	were	be	VBD
cord-015021-pol2qm74	2369	3	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	2369	4	with	with	IN
cord-015021-pol2qm74	2369	5	IV	IV	NNP
cord-015021-pol2qm74	2369	6	Ringers	Ringers	NNPS
cord-015021-pol2qm74	2369	7	solution	solution	NN
cord-015021-pol2qm74	2369	8	(	(	-LRB-
cord-015021-pol2qm74	2369	9	10	10	CD
cord-015021-pol2qm74	2369	10	ml	ml	NN
cord-015021-pol2qm74	2369	11	/	/	SYM
cord-015021-pol2qm74	2369	12	kg	kg	NNP
cord-015021-pol2qm74	2369	13	/	/	SYM
cord-015021-pol2qm74	2369	14	hr	hr	NN
cord-015021-pol2qm74	2369	15	)	)	-RRB-
cord-015021-pol2qm74	2369	16	.	.	.
cord-015021-pol2qm74	2370	1	Hemodynamic	Hemodynamic	NNP
cord-015021-pol2qm74	2370	2	data	datum	NNS
cord-015021-pol2qm74	2370	3	were	be	VBD
cord-015021-pol2qm74	2370	4	collected	collect	VBN
cord-015021-pol2qm74	2370	5	at	at	IN
cord-015021-pol2qm74	2370	6	0	0	CD
cord-015021-pol2qm74	2370	7	,	,	,
cord-015021-pol2qm74	2370	8	2	2	CD
cord-015021-pol2qm74	2370	9	,	,	,
cord-015021-pol2qm74	2370	10	6	6	CD
cord-015021-pol2qm74	2370	11	,	,	,
cord-015021-pol2qm74	2370	12	10	10	CD
cord-015021-pol2qm74	2370	13	,	,	,
cord-015021-pol2qm74	2370	14	14	14	CD
cord-015021-pol2qm74	2370	15	,	,	,
cord-015021-pol2qm74	2370	16	and	and	CC
cord-015021-pol2qm74	2370	17	22	22	CD
cord-015021-pol2qm74	2370	18	hours	hour	NNS
cord-015021-pol2qm74	2370	19	using	use	VBG
cord-015021-pol2qm74	2370	20	intravascular	intravascular	JJ
cord-015021-pol2qm74	2370	21	catheters	catheter	NNS
cord-015021-pol2qm74	2370	22	and	and	CC
cord-015021-pol2qm74	2370	23	radionuclide	radionuclide	NN
cord-015021-pol2qm74	2370	24	heart	heart	NN
cord-015021-pol2qm74	2370	25	scans	scan	NNS
cord-015021-pol2qm74	2370	26	and	and	CC
cord-015021-pol2qm74	2370	27	analyzed	analyze	VBN
cord-015021-pol2qm74	2370	28	by	by	IN
cord-015021-pol2qm74	2370	29	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	2370	30	.	.	.
cord-015021-pol2qm74	2371	1	In	in	IN
cord-015021-pol2qm74	2371	2	both	both	CC
cord-015021-pol2qm74	2371	3	normal	normal	JJ
cord-015021-pol2qm74	2371	4	and	and	CC
cord-015021-pol2qm74	2371	5	endotoxemic	endotoxemic	JJ
cord-015021-pol2qm74	2371	6	animals	animal	NNS
cord-015021-pol2qm74	2371	7	,	,	,
cord-015021-pol2qm74	2371	8	L	L	NNP
cord-015021-pol2qm74	2371	9	-	-	HYPH
cord-015021-pol2qm74	2371	10	NMA	NMA	NNP
cord-015021-pol2qm74	2371	11	at	at	IN
cord-015021-pol2qm74	2371	12	all	all	DT
cord-015021-pol2qm74	2371	13	doses	dose	NNS
cord-015021-pol2qm74	2371	14	studied	study	VBD
cord-015021-pol2qm74	2371	15	similarly	similarly	RB
cord-015021-pol2qm74	2371	16	increased	increase	VBD
cord-015021-pol2qm74	2371	17	mean	mean	JJ
cord-015021-pol2qm74	2371	18	arterial	arterial	JJ
cord-015021-pol2qm74	2371	19	pressure	pressure	NN
cord-015021-pol2qm74	2371	20	(	(	-LRB-
cord-015021-pol2qm74	2371	21	p=0.07	p=0.07	NNP
cord-015021-pol2qm74	2371	22	)	)	-RRB-
cord-015021-pol2qm74	2371	23	,	,	,
cord-015021-pol2qm74	2371	24	and	and	CC
cord-015021-pol2qm74	2371	25	systemic	systemic	JJ
cord-015021-pol2qm74	2371	26	vascular	vascular	JJ
cord-015021-pol2qm74	2371	27	resistance	resistance	NN
cord-015021-pol2qm74	2371	28	index	index	NN
cord-015021-pol2qm74	2371	29	(	(	-LRB-
cord-015021-pol2qm74	2371	30	p=0.Ol	p=0.ol	XX
cord-015021-pol2qm74	2371	31	)	)	-RRB-
cord-015021-pol2qm74	2371	32	and	and	CC
cord-015021-pol2qm74	2371	33	decreased	decrease	VBD
cord-015021-pol2qm74	2371	34	cardiac	cardiac	JJ
cord-015021-pol2qm74	2371	35	index	index	NN
cord-015021-pol2qm74	2371	36	(	(	-LRB-
cord-015021-pol2qm74	2371	37	p=0.05	p=0.05	NNP
cord-015021-pol2qm74	2371	38	)	)	-RRB-
cord-015021-pol2qm74	2371	39	and	and	CC
cord-015021-pol2qm74	2371	40	oxygen	oxygen	NN
cord-015021-pol2qm74	2371	41	delivery	delivery	NN
cord-015021-pol2qm74	2371	42	index	index	NN
cord-015021-pol2qm74	2371	43	(	(	-LRB-
cord-015021-pol2qm74	2371	44	p=0.01	p=0.01	NNP
cord-015021-pol2qm74	2371	45	)	)	-RRB-
cord-015021-pol2qm74	2371	46	.	.	.
cord-015021-pol2qm74	2372	1	In	in	IN
cord-015021-pol2qm74	2372	2	contrast	contrast	NN
cord-015021-pol2qm74	2372	3	,	,	,
cord-015021-pol2qm74	2372	4	the	the	DT
cord-015021-pol2qm74	2372	5	effect	effect	NN
cord-015021-pol2qm74	2372	6	of	of	IN
cord-015021-pol2qm74	2372	7	L	L	NNP
cord-015021-pol2qm74	2372	8	-	-	HYPH
cord-015021-pol2qm74	2372	9	NMA	NMA	NNP
cord-015021-pol2qm74	2372	10	on	on	IN
cord-015021-pol2qm74	2372	11	mean	mean	JJ
cord-015021-pol2qm74	2372	12	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2372	13	artery	artery	NN
cord-015021-pol2qm74	2372	14	pressure	pressure	NN
cord-015021-pol2qm74	2372	15	,	,	,
cord-015021-pol2qm74	2372	16	central	central	JJ
cord-015021-pol2qm74	2372	17	venous	venous	JJ
cord-015021-pol2qm74	2372	18	pressure	pressure	NN
cord-015021-pol2qm74	2372	19	,	,	,
cord-015021-pol2qm74	2372	20	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2372	21	capillary	capillary	JJ
cord-015021-pol2qm74	2372	22	wedge	wedge	NN
cord-015021-pol2qm74	2372	23	pressure	pressure	NN
cord-015021-pol2qm74	2372	24	,	,	,
cord-015021-pol2qm74	2372	25	and	and	CC
cord-015021-pol2qm74	2372	26	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2372	27	vascular	vascular	JJ
cord-015021-pol2qm74	2372	28	resistance	resistance	NN
cord-015021-pol2qm74	2372	29	index	index	NN
cord-015021-pol2qm74	2372	30	was	be	VBD
cord-015021-pol2qm74	2372	31	greater	great	JJR
cord-015021-pol2qm74	2372	32	in	in	IN
cord-015021-pol2qm74	2372	33	LPS	LPS	NNP
cord-015021-pol2qm74	2372	34	-	-	HYPH
cord-015021-pol2qm74	2372	35	challenged	challenge	VBN
cord-015021-pol2qm74	2372	36	canines	canine	NNS
cord-015021-pol2qm74	2372	37	compared	compare	VBN
cord-015021-pol2qm74	2372	38	to	to	IN
cord-015021-pol2qm74	2372	39	normal	normal	JJ
cord-015021-pol2qm74	2372	40	animals	animal	NNS
cord-015021-pol2qm74	2372	41	(	(	-LRB-
cord-015021-pol2qm74	2372	42	p<0.05	p<0.05	CD
cord-015021-pol2qm74	2372	43	)	)	-RRB-
cord-015021-pol2qm74	2372	44	,	,	,
cord-015021-pol2qm74	2372	45	but	but	CC
cord-015021-pol2qm74	2372	46	this	this	DT
cord-015021-pol2qm74	2372	47	differential	differential	JJ
cord-015021-pol2qm74	2372	48	effect	effect	NN
cord-015021-pol2qm74	2372	49	on	on	IN
cord-015021-pol2qm74	2372	50	the	the	DT
cord-015021-pol2qm74	2372	51	venous	venous	JJ
cord-015021-pol2qm74	2372	52	and	and	CC
cord-015021-pol2qm74	2372	53	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2372	54	circulation	circulation	NN
cord-015021-pol2qm74	2372	55	occurred	occur	VBD
cord-015021-pol2qm74	2372	56	,	,	,
cord-015021-pol2qm74	2372	57	>	>	XX
cord-015021-pol2qm74	2372	58	6	6	CD
cord-015021-pol2qm74	2372	59	hours	hour	NNS
cord-015021-pol2qm74	2372	60	after	after	IN
cord-015021-pol2qm74	2372	61	LPS	LPS	NNP
cord-015021-pol2qm74	2372	62	challenge	challenge	NN
cord-015021-pol2qm74	2372	63	.	.	.
cord-015021-pol2qm74	2373	1	L	L	NNP
cord-015021-pol2qm74	2373	2	-	-	HYPH
cord-015021-pol2qm74	2373	3	NMA	NMA	NNP
cord-015021-pol2qm74	2373	4	did	do	VBD
cord-015021-pol2qm74	2373	5	not	not	RB
cord-015021-pol2qm74	2373	6	significantly	significantly	RB
cord-015021-pol2qm74	2373	7	increase	increase	VB
cord-015021-pol2qm74	2373	8	survival	survival	NN
cord-015021-pol2qm74	2373	9	rates	rate	NNS
cord-015021-pol2qm74	2373	10	or	or	CC
cord-015021-pol2qm74	2373	11	times	time	NNS
cord-015021-pol2qm74	2373	12	at	at	IN
cord-015021-pol2qm74	2373	13	any	any	DT
cord-015021-pol2qm74	2373	14	of	of	IN
cord-015021-pol2qm74	2373	15	the	the	DT
cord-015021-pol2qm74	2373	16	doses	dose	NNS
cord-015021-pol2qm74	2373	17	studied	study	VBN
cord-015021-pol2qm74	2373	18	(	(	-LRB-
cord-015021-pol2qm74	2373	19	1	1	CD
cord-015021-pol2qm74	2373	20	,	,	,
cord-015021-pol2qm74	2373	21	2	2	CD
cord-015021-pol2qm74	2373	22	,	,	,
cord-015021-pol2qm74	2373	23	4	4	CD
cord-015021-pol2qm74	2373	24	,	,	,
cord-015021-pol2qm74	2373	25	or	or	CC
cord-015021-pol2qm74	2373	26	10	10	CD
cord-015021-pol2qm74	2373	27	mg	mg	NNP
cord-015021-pol2qm74	2373	28	/	/	SYM
cord-015021-pol2qm74	2373	29	kg	kg	NNP
cord-015021-pol2qm74	2373	30	/	/	SYM
cord-015021-pol2qm74	2373	31	h	h	NN
cord-015021-pol2qm74	2373	32	)	)	-RRB-
cord-015021-pol2qm74	2373	33	in	in	IN
cord-015021-pol2qm74	2373	34	either	either	CC
cord-015021-pol2qm74	2373	35	the	the	DT
cord-015021-pol2qm74	2373	36	low	low	JJ
cord-015021-pol2qm74	2373	37	(	(	-LRB-
cord-015021-pol2qm74	2373	38	8	8	CD
cord-015021-pol2qm74	2373	39	mg	mg	NNP
cord-015021-pol2qm74	2373	40	/	/	SYM
cord-015021-pol2qm74	2373	41	kg	kg	NNP
cord-015021-pol2qm74	2373	42	)	)	-RRB-
cord-015021-pol2qm74	2373	43	or	or	CC
cord-015021-pol2qm74	2373	44	high	high	JJ
cord-015021-pol2qm74	2373	45	dose	dose	NN
cord-015021-pol2qm74	2373	46	(	(	-LRB-
cord-015021-pol2qm74	2373	47	16	16	CD
cord-015021-pol2qm74	2373	48	mg	mg	NNP
cord-015021-pol2qm74	2373	49	/	/	SYM
cord-015021-pol2qm74	2373	50	kg	kg	NNP
cord-015021-pol2qm74	2373	51	)	)	-RRB-
cord-015021-pol2qm74	2373	52	LPS	LPS	NNP
cord-015021-pol2qm74	2373	53	-	-	HYPH
cord-015021-pol2qm74	2373	54	challenge	challenge	NN
cord-015021-pol2qm74	2373	55	groups	group	NNS
cord-015021-pol2qm74	2373	56	.	.	.
cord-015021-pol2qm74	2374	1	A	a	DT
cord-015021-pol2qm74	2374	2	nonsignificant	nonsignificant	JJ
cord-015021-pol2qm74	2374	3	(	(	-LRB-
cord-015021-pol2qm74	2374	4	p>0.2	p>0.2	JJ
cord-015021-pol2qm74	2374	5	)	)	-RRB-
cord-015021-pol2qm74	2374	6	trend	trend	NN
cord-015021-pol2qm74	2374	7	toward	toward	IN
cord-015021-pol2qm74	2374	8	a	a	DT
cord-015021-pol2qm74	2374	9	beneficial	beneficial	JJ
cord-015021-pol2qm74	2374	10	effect	effect	NN
cord-015021-pol2qm74	2374	11	on	on	IN
cord-015021-pol2qm74	2374	12	survival	survival	NN
cord-015021-pol2qm74	2374	13	ol	old	IN
cord-015021-pol2qm74	2374	14	low	low	JJ
cord-015021-pol2qm74	2374	15	dose	dose	NN
cord-015021-pol2qm74	2374	16	L	L	NNP
cord-015021-pol2qm74	2374	17	-	-	HYPH
cord-015021-pol2qm74	2374	18	NMA	NMA	NNP
cord-015021-pol2qm74	2374	19	(	(	-LRB-
cord-015021-pol2qm74	2374	20	1	1	CD
cord-015021-pol2qm74	2374	21	mg	mg	NNP
cord-015021-pol2qm74	2374	22	/	/	SYM
cord-015021-pol2qm74	2374	23	kg	kg	NNP
cord-015021-pol2qm74	2374	24	/	/	SYM
cord-015021-pol2qm74	2374	25	h	h	NN
cord-015021-pol2qm74	2374	26	)	)	-RRB-
cord-015021-pol2qm74	2374	27	in	in	IN
cord-015021-pol2qm74	2374	28	animals	animal	NNS
cord-015021-pol2qm74	2375	1	given	give	VBN
cord-015021-pol2qm74	2375	2	the	the	DT
cord-015021-pol2qm74	2375	3	8	8	CD
cord-015021-pol2qm74	2375	4	mg	mg	NNP
cord-015021-pol2qm74	2375	5	/	/	SYM
cord-015021-pol2qm74	2375	6	kg	kg	NNP
cord-015021-pol2qm74	2375	7	LPS	LPS	NNP
cord-015021-pol2qm74	2375	8	-	-	HYPH
cord-015021-pol2qm74	2375	9	cha[lenge	cha[lenge	NNP
cord-015021-pol2qm74	2376	1	was	be	VBD
cord-015021-pol2qm74	2376	2	not	not	RB
cord-015021-pol2qm74	2376	3	enhanced	enhance	VBN
cord-015021-pol2qm74	2376	4	by	by	IN
cord-015021-pol2qm74	2376	5	increasing	increase	VBG
cord-015021-pol2qm74	2376	6	the	the	DT
cord-015021-pol2qm74	2376	7	lethality	lethality	NN
cord-015021-pol2qm74	2376	8	of	of	IN
cord-015021-pol2qm74	2376	9	the	the	DT
cord-015021-pol2qm74	2376	10	model	model	NN
cord-015021-pol2qm74	2376	11	or	or	CC
cord-015021-pol2qm74	2376	12	by	by	IN
cord-015021-pol2qm74	2376	13	administering	administer	VBG
cord-015021-pol2qm74	2376	14	higher	high	JJR
cord-015021-pol2qm74	2376	15	L	L	NNP
cord-015021-pol2qm74	2376	16	-	-	HYPH
cord-015021-pol2qm74	2376	17	NMA	NMA	NNP
cord-015021-pol2qm74	2376	18	doses	dose	NNS
cord-015021-pol2qm74	2376	19	.	.	.
cord-015021-pol2qm74	2377	1	At	at	IN
cord-015021-pol2qm74	2377	2	the	the	DT
cord-015021-pol2qm74	2377	3	highest	high	JJS
cord-015021-pol2qm74	2377	4	L	L	NNP
cord-015021-pol2qm74	2377	5	-	-	HYPH
cord-015021-pol2qm74	2377	6	NMA	NMA	NNP
cord-015021-pol2qm74	2377	7	dose	dose	NN
cord-015021-pol2qm74	2377	8	used	use	VBN
cord-015021-pol2qm74	2377	9	in	in	IN
cord-015021-pol2qm74	2377	10	this	this	DT
cord-015021-pol2qm74	2377	11	study	study	NN
cord-015021-pol2qm74	2377	12	(	(	-LRB-
cord-015021-pol2qm74	2377	13	10	10	CD
cord-015021-pol2qm74	2377	14	mg	mg	NNP
cord-015021-pol2qm74	2377	15	/	/	SYM
cord-015021-pol2qm74	2377	16	kg	kg	NNP
cord-015021-pol2qm74	2377	17	/	/	SYM
cord-015021-pol2qm74	2377	18	h	h	NNP
cord-015021-pol2qm74	2377	19	)	)	-RRB-
cord-015021-pol2qm74	2377	20	,	,	,
cord-015021-pol2qm74	2377	21	survival	survival	NN
cord-015021-pol2qm74	2377	22	time	time	NN
cord-015021-pol2qm74	2377	23	decreased	decrease	VBD
cord-015021-pol2qm74	2377	24	significantly	significantly	RB
cord-015021-pol2qm74	2377	25	for	for	IN
cord-015021-pol2qm74	2377	26	both	both	CC
cord-015021-pol2qm74	2377	27	the	the	DT
cord-015021-pol2qm74	2377	28	low	low	JJ
cord-015021-pol2qm74	2377	29	and	and	CC
cord-015021-pol2qm74	2377	30	high	high	JJ
cord-015021-pol2qm74	2377	31	dose	dose	NN
cord-015021-pol2qm74	2377	32	LPS	LPS	NNP
cord-015021-pol2qm74	2377	33	-	-	HYPH
cord-015021-pol2qm74	2377	34	challenge	challenge	NN
cord-015021-pol2qm74	2377	35	animals	animal	NNS
cord-015021-pol2qm74	2377	36	(	(	-LRB-
cord-015021-pol2qm74	2377	37	p<0.05	p<0.05	CD
cord-015021-pol2qm74	2377	38	)	)	-RRB-
cord-015021-pol2qm74	2377	39	.	.	.
cord-015021-pol2qm74	2378	1	This	this	DT
cord-015021-pol2qm74	2378	2	increased	increase	VBN
cord-015021-pol2qm74	2378	3	mortality	mortality	NN
cord-015021-pol2qm74	2378	4	was	be	VBD
cord-015021-pol2qm74	2378	5	not	not	RB
cord-015021-pol2qm74	2378	6	explained	explain	VBN
cord-015021-pol2qm74	2378	7	by	by	IN
cord-015021-pol2qm74	2378	8	changes	change	NNS
cord-015021-pol2qm74	2378	9	in	in	IN
cord-015021-pol2qm74	2378	10	plasma	plasma	NN
cord-015021-pol2qm74	2378	11	concentrations	concentration	NNS
cord-015021-pol2qm74	2378	12	of	of	IN
cord-015021-pol2qm74	2378	13	either	either	DT
cord-015021-pol2qm74	2378	14	LPS	LPS	NNP
cord-015021-pol2qm74	2378	15	or	or	CC
cord-015021-pol2qm74	2378	16	TNFc~.	TNFc~.	NNP
cord-015021-pol2qm74	2379	1	Thus	thus	RB
cord-015021-pol2qm74	2379	2	,	,	,
cord-015021-pol2qm74	2379	3	L	L	NNP
cord-015021-pol2qm74	2379	4	-	-	HYPH
cord-015021-pol2qm74	2379	5	NMA	NMA	NNP
cord-015021-pol2qm74	2379	6	did	do	VBD
cord-015021-pol2qm74	2379	7	not	not	RB
cord-015021-pol2qm74	2379	8	have	have	VB
cord-015021-pol2qm74	2379	9	a	a	DT
cord-015021-pol2qm74	2379	10	greater	great	JJR
cord-015021-pol2qm74	2379	11	effect	effect	NN
cord-015021-pol2qm74	2379	12	on	on	IN
cord-015021-pol2qm74	2379	13	the	the	DT
cord-015021-pol2qm74	2379	14	systemic	systemic	JJ
cord-015021-pol2qm74	2379	15	arterial	arterial	JJ
cord-015021-pol2qm74	2379	16	circulation	circulation	NN
cord-015021-pol2qm74	2379	17	in	in	IN
cord-015021-pol2qm74	2379	18	endotoxemic	endotoxemic	NNP
cord-015021-pol2qm74	2379	19	compared	compare	VBN
cord-015021-pol2qm74	2379	20	to	to	IN
cord-015021-pol2qm74	2379	21	normal	normal	JJ
cord-015021-pol2qm74	2379	22	canines	canine	NNS
cord-015021-pol2qm74	2379	23	.	.	.
cord-015021-pol2qm74	2380	1	However	however	RB
cord-015021-pol2qm74	2380	2	,	,	,
cord-015021-pol2qm74	2380	3	in	in	IN
cord-015021-pol2qm74	2380	4	the	the	DT
cord-015021-pol2qm74	2380	5	venous	venous	JJ
cord-015021-pol2qm74	2380	6	and	and	CC
cord-015021-pol2qm74	2380	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2380	8	vascular	vascular	JJ
cord-015021-pol2qm74	2380	9	beds	bed	NNS
cord-015021-pol2qm74	2380	10	,	,	,
cord-015021-pol2qm74	2380	11	the	the	DT
cord-015021-pol2qm74	2380	12	effect	effect	NN
cord-015021-pol2qm74	2380	13	of	of	IN
cord-015021-pol2qm74	2380	14	L	L	NNP
cord-015021-pol2qm74	2380	15	-	-	HYPH
cord-015021-pol2qm74	2380	16	NMA	NMA	NNP
cord-015021-pol2qm74	2380	17	increased	increase	VBD
cord-015021-pol2qm74	2380	18	with	with	IN
cord-015021-pol2qm74	2380	19	time	time	NN
cord-015021-pol2qm74	2380	20	after	after	IN
cord-015021-pol2qm74	2380	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2380	22	-	-	HYPH
cord-015021-pol2qm74	2380	23	challenge	challenge	NN
cord-015021-pol2qm74	2380	24	These	these	DT
cord-015021-pol2qm74	2380	25	data	datum	NNS
cord-015021-pol2qm74	2380	26	suggest	suggest	VBP
cord-015021-pol2qm74	2380	27	the	the	DT
cord-015021-pol2qm74	2380	28	induction	induction	NN
cord-015021-pol2qm74	2380	29	of	of	IN
cord-015021-pol2qm74	2380	30	NOS	NOS	NNP
cord-015021-pol2qm74	2380	31	activity	activity	NN
cord-015021-pol2qm74	2380	32	by	by	IN
cord-015021-pol2qm74	2380	33	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2380	34	in	in	IN
cord-015021-pol2qm74	2380	35	canines	canine	NNS
cord-015021-pol2qm74	2380	36	may	may	MD
cord-015021-pol2qm74	2380	37	be	be	VB
cord-015021-pol2qm74	2380	38	relatively	relatively	RB
cord-015021-pol2qm74	2380	39	greater	great	JJR
cord-015021-pol2qm74	2380	40	in	in	IN
cord-015021-pol2qm74	2380	41	venous	venous	JJ
cord-015021-pol2qm74	2380	42	and	and	CC
cord-015021-pol2qm74	2380	43	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2380	44	vessels	vessel	NNS
cord-015021-pol2qm74	2380	45	compared	compare	VBN
cord-015021-pol2qm74	2380	46	to	to	IN
cord-015021-pol2qm74	2380	47	systernic	systernic	JJ
cord-015021-pol2qm74	2380	48	arteries	artery	NNS
cord-015021-pol2qm74	2380	49	.	.	.
cord-015021-pol2qm74	2381	1	L	L	NNP
cord-015021-pol2qm74	2381	2	-	-	HYPH
cord-015021-pol2qm74	2381	3	NMA	NMA	NNP
cord-015021-pol2qm74	2381	4	,	,	,
cord-015021-pol2qm74	2381	5	a	a	DT
cord-015021-pol2qm74	2381	6	nonselective	nonselective	JJ
cord-015021-pol2qm74	2381	7	NOS	NOS	NNP
cord-015021-pol2qm74	2381	8	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2381	9	,	,	,
cord-015021-pol2qm74	2381	10	did	do	VBD
cord-015021-pol2qm74	2381	11	not	not	RB
cord-015021-pol2qm74	2381	12	decrease	decrease	VB
cord-015021-pol2qm74	2381	13	mortality	mortality	NN
cord-015021-pol2qm74	2381	14	in	in	IN
cord-015021-pol2qm74	2381	15	endoloxemic	endoloxemic	JJ
cord-015021-pol2qm74	2381	16	canines	canines	NNPS
cord-015021-pol2qm74	2381	17	and	and	CC
cord-015021-pol2qm74	2381	18	the	the	DT
cord-015021-pol2qm74	2381	19	highest	high	JJS
cord-015021-pol2qm74	2381	20	dose	dose	NN
cord-015021-pol2qm74	2381	21	studied	study	VBN
cord-015021-pol2qm74	2381	22	was	be	VBD
cord-015021-pol2qm74	2381	23	harmful	harmful	JJ
cord-015021-pol2qm74	2381	24	.	.	.
cord-015021-pol2qm74	2382	1	Pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2382	2	hypertension	hypertension	NN
cord-015021-pol2qm74	2382	3	(	(	-LRB-
cord-015021-pol2qm74	2382	4	PH	PH	NNP
cord-015021-pol2qm74	2382	5	)	)	-RRB-
cord-015021-pol2qm74	2382	6	and	and	CC
cord-015021-pol2qm74	2382	7	arterial	arterial	JJ
cord-015021-pol2qm74	2382	8	hypoxemia	hypoxemia	NN
cord-015021-pol2qm74	2382	9	are	be	VBP
cord-015021-pol2qm74	2382	10	characteristic	characteristic	JJ
cord-015021-pol2qm74	2382	11	features	feature	NNS
cord-015021-pol2qm74	2382	12	of	of	IN
cord-015021-pol2qm74	2382	13	the	the	DT
cord-015021-pol2qm74	2382	14	adult	adult	NN
cord-015021-pol2qm74	2382	15	respiratory	respiratory	JJ
cord-015021-pol2qm74	2382	16	distress	distress	NN
cord-015021-pol2qm74	2382	17	syndrome	syndrome	NN
cord-015021-pol2qm74	2382	18	(	(	-LRB-
cord-015021-pol2qm74	2382	19	ARDS	ARDS	NNP
cord-015021-pol2qm74	2382	20	)	)	-RRB-
cord-015021-pol2qm74	2382	21	.	.	.
cord-015021-pol2qm74	2383	1	Reducing	reduce	VBG
cord-015021-pol2qm74	2383	2	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2383	3	vascular	vascular	JJ
cord-015021-pol2qm74	2383	4	pressures	pressure	NNS
cord-015021-pol2qm74	2383	5	may	may	MD
cord-015021-pol2qm74	2383	6	promote	promote	VB
cord-015021-pol2qm74	2383	7	the	the	DT
cord-015021-pol2qm74	2383	8	resolution	resolution	NN
cord-015021-pol2qm74	2383	9	of	of	IN
cord-015021-pol2qm74	2383	10	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2383	11	edema	edema	NN
cord-015021-pol2qm74	2383	12	.	.	.
cord-015021-pol2qm74	2384	1	Intravenously	intravenously	RB
cord-015021-pol2qm74	2384	2	infused	infuse	VBN
cord-015021-pol2qm74	2384	3	vasodilators	vasodilator	NNS
cord-015021-pol2qm74	2384	4	lower	low	JJR
cord-015021-pol2qm74	2384	5	PH	PH	NNP
cord-015021-pol2qm74	2384	6	in	in	IN
cord-015021-pol2qm74	2384	7	ARDS	ARDS	NNP
cord-015021-pol2qm74	2384	8	,	,	,
cord-015021-pol2qm74	2384	9	but	but	CC
cord-015021-pol2qm74	2384	10	,	,	,
cord-015021-pol2qm74	2384	11	as	as	IN
cord-015021-pol2qm74	2384	12	a	a	DT
cord-015021-pol2qm74	2384	13	result	result	NN
cord-015021-pol2qm74	2384	14	of	of	IN
cord-015021-pol2qm74	2384	15	their	-PRON-	PRP$
cord-015021-pol2qm74	2384	16	general	general	JJ
cord-015021-pol2qm74	2384	17	vasodilatatory	vasodilatatory	NN
cord-015021-pol2qm74	2384	18	effects	effect	NNS
cord-015021-pol2qm74	2384	19	,	,	,
cord-015021-pol2qm74	2384	20	systemic	systemic	JJ
cord-015021-pol2qm74	2384	21	mean	mean	JJ
cord-015021-pol2qm74	2384	22	arterial	arterial	JJ
cord-015021-pol2qm74	2384	23	pressure	pressure	NN
cord-015021-pol2qm74	2384	24	may	may	MD
cord-015021-pol2qm74	2384	25	also	also	RB
cord-015021-pol2qm74	2384	26	decrease	decrease	VB
cord-015021-pol2qm74	2384	27	.	.	.
cord-015021-pol2qm74	2385	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2385	2	,	,	,
cord-015021-pol2qm74	2385	3	blood	blood	NN
cord-015021-pol2qm74	2385	4	flow	flow	NN
cord-015021-pol2qm74	2385	5	may	may	MD
cord-015021-pol2qm74	2385	6	be	be	VB
cord-015021-pol2qm74	2385	7	increased	increase	VBN
cord-015021-pol2qm74	2385	8	to	to	IN
cord-015021-pol2qm74	2385	9	non	non	JJ
cord-015021-pol2qm74	2385	10	-	-	JJ
cord-015021-pol2qm74	2385	11	ventilated	ventilated	JJ
cord-015021-pol2qm74	2385	12	or	or	CC
cord-015021-pol2qm74	2385	13	poorly	poorly	RB
cord-015021-pol2qm74	2385	14	ventilated	ventilate	VBN
cord-015021-pol2qm74	2385	15	lung	lung	NN
cord-015021-pol2qm74	2385	16	areas	area	NNS
cord-015021-pol2qm74	2385	17	resulting	result	VBG
cord-015021-pol2qm74	2385	18	in	in	IN
cord-015021-pol2qm74	2385	19	a	a	DT
cord-015021-pol2qm74	2385	20	rise	rise	NN
cord-015021-pol2qm74	2385	21	of	of	IN
cord-015021-pol2qm74	2385	22	intrapulmonary	intrapulmonary	JJ
cord-015021-pol2qm74	2385	23	shunt	shunt	NN
cord-015021-pol2qm74	2385	24	,	,	,
cord-015021-pol2qm74	2385	25	thus	thus	RB
cord-015021-pol2qm74	2385	26	causing	cause	VBG
cord-015021-pol2qm74	2385	27	a	a	DT
cord-015021-pol2qm74	2385	28	further	further	JJ
cord-015021-pol2qm74	2385	29	fall	fall	NN
cord-015021-pol2qm74	2385	30	in	in	IN
cord-015021-pol2qm74	2385	31	PaD	pad	NN
cord-015021-pol2qm74	2385	32	2	2	CD
cord-015021-pol2qm74	2385	33	.	.	.
cord-015021-pol2qm74	2386	1	Recently	recently	RB
cord-015021-pol2qm74	2386	2	,	,	,
cord-015021-pol2qm74	2386	3	short	short	JJ
cord-015021-pol2qm74	2386	4	term	term	NN
cord-015021-pol2qm74	2386	5	inhalation	inhalation	NN
cord-015021-pol2qm74	2386	6	of	of	IN
cord-015021-pol2qm74	2386	7	low	low	JJ
cord-015021-pol2qm74	2386	8	concentrations	concentration	NNS
cord-015021-pol2qm74	2386	9	of	of	IN
cord-015021-pol2qm74	2386	10	the	the	DT
cord-015021-pol2qm74	2386	11	gas	gas	NN
cord-015021-pol2qm74	2386	12	nitric	nitric	NN
cord-015021-pol2qm74	2386	13	oxide	oxide	NN
cord-015021-pol2qm74	2386	14	(	(	-LRB-
cord-015021-pol2qm74	2386	15	NO	no	UH
cord-015021-pol2qm74	2386	16	)	)	-RRB-
cord-015021-pol2qm74	2386	17	,	,	,
cord-015021-pol2qm74	2386	18	an	an	DT
cord-015021-pol2qm74	2386	19	endogenous	endogenous	JJ
cord-015021-pol2qm74	2386	20	endothelium	endothelium	NN
cord-015021-pol2qm74	2386	21	derived	derive	VBN
cord-015021-pol2qm74	2386	22	relaxing	relax	VBG
cord-015021-pol2qm74	2386	23	factor	factor	NN
cord-015021-pol2qm74	2386	24	,	,	,
cord-015021-pol2qm74	2386	25	which	which	WDT
cord-015021-pol2qm74	2386	26	is	be	VBZ
cord-015021-pol2qm74	2386	27	rapidly	rapidly	RB
cord-015021-pol2qm74	2386	28	inactivated	inactivate	VBN
cord-015021-pol2qm74	2386	29	in	in	IN
cord-015021-pol2qm74	2386	30	blood	blood	NN
cord-015021-pol2qm74	2386	31	by	by	IN
cord-015021-pol2qm74	2386	32	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	2386	33	,	,	,
cord-015021-pol2qm74	2386	34	was	be	VBD
cord-015021-pol2qm74	2386	35	reported	report	VBN
cord-015021-pol2qm74	2386	36	to	to	TO
cord-015021-pol2qm74	2386	37	decrease	decrease	VB
cord-015021-pol2qm74	2386	38	PH	PH	NNP
cord-015021-pol2qm74	2386	39	without	without	IN
cord-015021-pol2qm74	2386	40	causing	cause	VBG
cord-015021-pol2qm74	2386	41	systemic	systemic	JJ
cord-015021-pol2qm74	2386	42	vasodilation	vasodilation	NN
cord-015021-pol2qm74	2386	43	in	in	IN
cord-015021-pol2qm74	2386	44	sheep	sheep	NN
cord-015021-pol2qm74	2386	45	[	[	-LRB-
cord-015021-pol2qm74	2386	46	1	1	CD
cord-015021-pol2qm74	2386	47	]	]	-RRB-
cord-015021-pol2qm74	2386	48	.	.	.
cord-015021-pol2qm74	2387	1	Similar	similar	JJ
cord-015021-pol2qm74	2387	2	changes	change	NNS
cord-015021-pol2qm74	2387	3	have	have	VBP
cord-015021-pol2qm74	2387	4	been	be	VBN
cord-015021-pol2qm74	2387	5	observed	observe	VBN
cord-015021-pol2qm74	2387	6	in	in	IN
cord-015021-pol2qm74	2387	7	patients	patient	NNS
cord-015021-pol2qm74	2387	8	with	with	IN
cord-015021-pol2qm74	2387	9	severe	severe	JJ
cord-015021-pol2qm74	2387	10	ARDS	ARDS	NNP
cord-015021-pol2qm74	2387	11	during	during	IN
cord-015021-pol2qm74	2387	12	repeated	repeat	VBN
cord-015021-pol2qm74	2387	13	short	short	JJ
cord-015021-pol2qm74	2387	14	term	term	NN
cord-015021-pol2qm74	2387	15	inhalation	inhalation	NN
cord-015021-pol2qm74	2387	16	of	of	IN
cord-015021-pol2qm74	2387	17	NO	NO	NNP
cord-015021-pol2qm74	2387	18	(	(	-LRB-
cord-015021-pol2qm74	2387	19	18	18	CD
cord-015021-pol2qm74	2387	20	and	and	CC
cord-015021-pol2qm74	2387	21	36	36	CD
cord-015021-pol2qm74	2387	22	ppm	ppm	NN
cord-015021-pol2qm74	2387	23	)	)	-RRB-
cord-015021-pol2qm74	2387	24	,	,	,
cord-015021-pol2qm74	2387	25	which	which	WDT
cord-015021-pol2qm74	2387	26	rapidly	rapidly	RB
cord-015021-pol2qm74	2387	27	and	and	CC
cord-015021-pol2qm74	2387	28	selectively	selectively	RB
cord-015021-pol2qm74	2387	29	decreased	decrease	VBD
cord-015021-pol2qm74	2387	30	the	the	DT
cord-015021-pol2qm74	2387	31	mean	mean	JJ
cord-015021-pol2qm74	2387	32	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2387	33	artery	artery	NN
cord-015021-pol2qm74	2387	34	pressure	pressure	NN
cord-015021-pol2qm74	2387	35	(	(	-LRB-
cord-015021-pol2qm74	2387	36	PAP	pap	NN
cord-015021-pol2qm74	2387	37	)	)	-RRB-
cord-015021-pol2qm74	2387	38	and	and	CC
cord-015021-pol2qm74	2387	39	,	,	,
cord-015021-pol2qm74	2387	40	in	in	IN
cord-015021-pol2qm74	2387	41	contrast	contrast	NN
cord-015021-pol2qm74	2387	42	to	to	IN
cord-015021-pol2qm74	2387	43	intravenously	intravenously	RB
cord-015021-pol2qm74	2387	44	infused	infuse	VBN
cord-015021-pol2qm74	2387	45	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	2387	46	,	,	,
cord-015021-pol2qm74	2387	47	induced	induce	VBD
cord-015021-pol2qm74	2387	48	a	a	DT
cord-015021-pol2qm74	2387	49	remarkable	remarkable	JJ
cord-015021-pol2qm74	2387	50	increase	increase	NN
cord-015021-pol2qm74	2387	51	of	of	IN
cord-015021-pol2qm74	2387	52	PaD2	PaD2	NNS
cord-015021-pol2qm74	2387	53	[	[	-LRB-
cord-015021-pol2qm74	2387	54	2	2	CD
cord-015021-pol2qm74	2387	55	]	]	-RRB-
cord-015021-pol2qm74	2387	56	.	.	.
cord-015021-pol2qm74	2388	1	This	this	DT
cord-015021-pol2qm74	2388	2	improvement	improvement	NN
cord-015021-pol2qm74	2388	3	in	in	IN
cord-015021-pol2qm74	2388	4	oxygenation	oxygenation	NN
cord-015021-pol2qm74	2388	5	was	be	VBD
cord-015021-pol2qm74	2388	6	caused	cause	VBN
cord-015021-pol2qm74	2388	7	by	by	IN
cord-015021-pol2qm74	2388	8	a	a	DT
cord-015021-pol2qm74	2388	9	redistribution	redistribution	NN
cord-015021-pol2qm74	2388	10	in	in	IN
cord-015021-pol2qm74	2388	11	blood	blood	NN
cord-015021-pol2qm74	2388	12	flow	flow	NN
cord-015021-pol2qm74	2388	13	away	away	RB
cord-015021-pol2qm74	2388	14	from	from	IN
cord-015021-pol2qm74	2388	15	intrapulmonary	intrapulmonary	JJ
cord-015021-pol2qm74	2388	16	shunt	shunt	NN
cord-015021-pol2qm74	2388	17	areas	area	NNS
cord-015021-pol2qm74	2388	18	to	to	IN
cord-015021-pol2qm74	2388	19	normal	normal	JJ
cord-015021-pol2qm74	2388	20	ventilated	ventilate	VBN
cord-015021-pol2qm74	2388	21	lung	lung	NN
cord-015021-pol2qm74	2388	22	regions	region	NNS
cord-015021-pol2qm74	2388	23	.	.	.
cord-015021-pol2qm74	2389	1	Continuous	continuous	JJ
cord-015021-pol2qm74	2389	2	NO	no	DT
cord-015021-pol2qm74	2389	3	inhalation	inhalation	NN
cord-015021-pol2qm74	2389	4	(	(	-LRB-
cord-015021-pol2qm74	2389	5	5	5	CD
cord-015021-pol2qm74	2389	6	-	-	SYM
cord-015021-pol2qm74	2389	7	20	20	CD
cord-015021-pol2qm74	2389	8	ppm	ppm	NN
cord-015021-pol2qm74	2389	9	)	)	-RRB-
cord-015021-pol2qm74	2389	10	consistently	consistently	RB
cord-015021-pol2qm74	2389	11	lowered	lower	VBD
cord-015021-pol2qm74	2389	12	the	the	DT
cord-015021-pol2qm74	2389	13	PAP	pap	NN
cord-015021-pol2qm74	2389	14	and	and	CC
cord-015021-pol2qm74	2389	15	augmented	augment	VBD
cord-015021-pol2qm74	2389	16	the	the	DT
cord-015021-pol2qm74	2389	17	PaO2	PaO2	NNPS
cord-015021-pol2qm74	2389	18	/	/	SYM
cord-015021-pol2qm74	2389	19	F.O	f.o	NN
cord-015021-pol2qm74	2389	20	2	2	CD
cord-015021-pol2qm74	2389	21	for	for	IN
cord-015021-pol2qm74	2389	22	up	up	IN
cord-015021-pol2qm74	2389	23	to	to	TO
cord-015021-pol2qm74	2389	24	53	53	CD
cord-015021-pol2qm74	2389	25	days	day	NNS
cord-015021-pol2qm74	2389	26	.	.	.
cord-015021-pol2qm74	2390	1	No	no	DT
cord-015021-pol2qm74	2390	2	negative	negative	JJ
cord-015021-pol2qm74	2390	3	side	side	NN
cord-015021-pol2qm74	2390	4	effects	effect	NNS
cord-015021-pol2qm74	2390	5	were	be	VBD
cord-015021-pol2qm74	2390	6	observed	observe	VBN
cord-015021-pol2qm74	2390	7	during	during	IN
cord-015021-pol2qm74	2390	8	the	the	DT
cord-015021-pol2qm74	2390	9	whole	whole	JJ
cord-015021-pol2qm74	2390	10	time	time	NN
cord-015021-pol2qm74	2390	11	span	span	NN
cord-015021-pol2qm74	2390	12	examined	examine	VBN
cord-015021-pol2qm74	2390	13	.	.	.
cord-015021-pol2qm74	2391	1	In	in	IN
cord-015021-pol2qm74	2391	2	particular	particular	JJ
cord-015021-pol2qm74	2391	3	methemoglobin	methemoglobin	JJ
cord-015021-pol2qm74	2391	4	levels	level	NNS
cord-015021-pol2qm74	2391	5	always	always	RB
cord-015021-pol2qm74	2391	6	remained	remain	VBD
cord-015021-pol2qm74	2391	7	below	below	IN
cord-015021-pol2qm74	2391	8	1.5	1.5	CD
cord-015021-pol2qm74	2391	9	%	%	NN
cord-015021-pol2qm74	2391	10	.	.	.
cord-015021-pol2qm74	2392	1	Following	follow	VBG
cord-015021-pol2qm74	2392	2	these	these	DT
cord-015021-pol2qm74	2392	3	investigations	investigation	NNS
cord-015021-pol2qm74	2392	4	,	,	,
cord-015021-pol2qm74	2392	5	it	-PRON-	PRP
cord-015021-pol2qm74	2392	6	could	could	MD
cord-015021-pol2qm74	2392	7	be	be	VB
cord-015021-pol2qm74	2392	8	shown	show	VBN
cord-015021-pol2qm74	2392	9	that	that	IN
cord-015021-pol2qm74	2392	10	these	these	DT
cord-015021-pol2qm74	2392	11	effects	effect	NNS
cord-015021-pol2qm74	2392	12	may	may	MD
cord-015021-pol2qm74	2392	13	also	also	RB
cord-015021-pol2qm74	2392	14	occur	occur	VB
cord-015021-pol2qm74	2392	15	using	use	VBG
cord-015021-pol2qm74	2392	16	concentrations	concentration	NNS
cord-015021-pol2qm74	2392	17	in	in	IN
cord-015021-pol2qm74	2392	18	the	the	DT
cord-015021-pol2qm74	2392	19	parts	part	NNS
cord-015021-pol2qm74	2392	20	per	per	IN
cord-015021-pol2qm74	2392	21	billion	billion	CD
cord-015021-pol2qm74	2392	22	range	range	NN
cord-015021-pol2qm74	2392	23	[	[	-LRB-
cord-015021-pol2qm74	2392	24	3	3	CD
cord-015021-pol2qm74	2392	25	]	]	-RRB-
cord-015021-pol2qm74	2392	26	,	,	,
cord-015021-pol2qm74	2392	27	which	which	WDT
cord-015021-pol2qm74	2392	28	may	may	MD
cord-015021-pol2qm74	2392	29	reduce	reduce	VB
cord-015021-pol2qm74	2392	30	possible	possible	JJ
cord-015021-pol2qm74	2392	31	toxic	toxic	JJ
cord-015021-pol2qm74	2392	32	side	side	NN
cord-015021-pol2qm74	2392	33	effects	effect	NNS
cord-015021-pol2qm74	2392	34	.	.	.
cord-015021-pol2qm74	2393	1	However	however	RB
cord-015021-pol2qm74	2393	2	,	,	,
cord-015021-pol2qm74	2393	3	in	in	IN
cord-015021-pol2qm74	2393	4	the	the	DT
cord-015021-pol2qm74	2393	5	same	same	JJ
cord-015021-pol2qm74	2393	6	study	study	NN
cord-015021-pol2qm74	2393	7	it	-PRON-	PRP
cord-015021-pol2qm74	2393	8	was	be	VBD
cord-015021-pol2qm74	2393	9	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2393	10	that	that	IN
cord-015021-pol2qm74	2393	11	the	the	DT
cord-015021-pol2qm74	2393	12	dose	dose	NN
cord-015021-pol2qm74	2393	13	-	-	HYPH
cord-015021-pol2qm74	2393	14	response	response	NN
cord-015021-pol2qm74	2393	15	curves	curve	NNS
cord-015021-pol2qm74	2393	16	for	for	IN
cord-015021-pol2qm74	2393	17	Pa02	Pa02	NNP
cord-015021-pol2qm74	2393	18	and	and	CC
cord-015021-pol2qm74	2393	19	PAP	pap	NN
cord-015021-pol2qm74	2393	20	have	have	VBP
cord-015021-pol2qm74	2393	21	different	different	JJ
cord-015021-pol2qm74	2393	22	patterns	pattern	NNS
cord-015021-pol2qm74	2393	23	.	.	.
cord-015021-pol2qm74	2394	1	Whereas	whereas	IN
cord-015021-pol2qm74	2394	2	PAP	PAP	NNP
cord-015021-pol2qm74	2394	3	presented	present	VBD
cord-015021-pol2qm74	2394	4	a	a	DT
cord-015021-pol2qm74	2394	5	continuous	continuous	JJ
cord-015021-pol2qm74	2394	6	dose	dose	NN
cord-015021-pol2qm74	2394	7	-	-	HYPH
cord-015021-pol2qm74	2394	8	dependent	dependent	JJ
cord-015021-pol2qm74	2394	9	downward	downward	JJ
cord-015021-pol2qm74	2394	10	tendency	tendency	NN
cord-015021-pol2qm74	2394	11	with	with	IN
cord-015021-pol2qm74	2394	12	an	an	DT
cord-015021-pol2qm74	2394	13	EDs	EDs	NNP
cord-015021-pol2qm74	2394	14	o	o	NN
cord-015021-pol2qm74	2394	15	of	of	IN
cord-015021-pol2qm74	2394	16	approximately	approximately	RB
cord-015021-pol2qm74	2394	17	2	2	CD
cord-015021-pol2qm74	2394	18	-	-	SYM
cord-015021-pol2qm74	2394	19	3	3	CD
cord-015021-pol2qm74	2394	20	ppm	ppm	NN
cord-015021-pol2qm74	2394	21	,	,	,
cord-015021-pol2qm74	2394	22	the	the	DT
cord-015021-pol2qm74	2394	23	improvement	improvement	NN
cord-015021-pol2qm74	2394	24	of	of	IN
cord-015021-pol2qm74	2394	25	oxygenation	oxygenation	NN
cord-015021-pol2qm74	2394	26	had	have	VBD
cord-015021-pol2qm74	2394	27	a	a	DT
cord-015021-pol2qm74	2394	28	maximum	maximum	NN
cord-015021-pol2qm74	2394	29	at	at	IN
cord-015021-pol2qm74	2394	30	10	10	CD
cord-015021-pol2qm74	2394	31	ppm	ppm	NN
cord-015021-pol2qm74	2394	32	and	and	CC
cord-015021-pol2qm74	2394	33	,	,	,
cord-015021-pol2qm74	2394	34	at	at	IN
cord-015021-pol2qm74	2394	35	higher	high	JJR
cord-015021-pol2qm74	2394	36	doses	dose	NNS
cord-015021-pol2qm74	2394	37	,	,	,
cord-015021-pol2qm74	2394	38	drifted	drift	VBD
cord-015021-pol2qm74	2394	39	back	back	RB
cord-015021-pol2qm74	2394	40	towards	towards	IN
cord-015021-pol2qm74	2394	41	the	the	DT
cord-015021-pol2qm74	2394	42	baseline	baseline	JJ
cord-015021-pol2qm74	2394	43	data	datum	NNS
cord-015021-pol2qm74	2394	44	.	.	.
cord-015021-pol2qm74	2395	1	The	the	DT
cord-015021-pol2qm74	2395	2	ED	ED	NNP
cord-015021-pol2qm74	2395	3	~	~	NFP
cord-015021-pol2qm74	2395	4	o	o	NNP
cord-015021-pol2qm74	2395	5	was	be	VBD
cord-015021-pol2qm74	2395	6	estimated	estimate	VBN
cord-015021-pol2qm74	2395	7	at	at	IN
cord-015021-pol2qm74	2395	8	approximately	approximately	RB
cord-015021-pol2qm74	2395	9	100	100	CD
cord-015021-pol2qm74	2395	10	ppb	ppb	NN
cord-015021-pol2qm74	2395	11	,	,	,
cord-015021-pol2qm74	2395	12	i.e.	i.e.	FW
cord-015021-pol2qm74	2395	13	more	more	JJR
cord-015021-pol2qm74	2395	14	than	than	IN
cord-015021-pol2qm74	2395	15	ten	ten	CD
cord-015021-pol2qm74	2395	16	times	time	NNS
cord-015021-pol2qm74	2395	17	lower	low	JJR
cord-015021-pol2qm74	2395	18	than	than	IN
cord-015021-pol2qm74	2395	19	for	for	IN
cord-015021-pol2qm74	2395	20	the	the	DT
cord-015021-pol2qm74	2395	21	reduction	reduction	NN
cord-015021-pol2qm74	2395	22	of	of	IN
cord-015021-pol2qm74	2395	23	PAP	pap	NN
cord-015021-pol2qm74	2395	24	.	.	.
cord-015021-pol2qm74	2396	1	In	in	IN
cord-015021-pol2qm74	2396	2	conclusion	conclusion	NN
cord-015021-pol2qm74	2396	3	,	,	,
cord-015021-pol2qm74	2396	4	inhalation	inhalation	NN
cord-015021-pol2qm74	2396	5	of	of	IN
cord-015021-pol2qm74	2396	6	NO	no	NN
cord-015021-pol2qm74	2396	7	by	by	IN
cord-015021-pol2qm74	2396	8	patients	patient	NNS
cord-015021-pol2qm74	2396	9	with	with	IN
cord-015021-pol2qm74	2396	10	severe	severe	JJ
cord-015021-pol2qm74	2396	11	ARDS	ARDS	NNP
cord-015021-pol2qm74	2396	12	may	may	MD
cord-015021-pol2qm74	2396	13	result	result	VB
cord-015021-pol2qm74	2396	14	in	in	IN
cord-015021-pol2qm74	2396	15	persistent	persistent	JJ
cord-015021-pol2qm74	2396	16	and	and	CC
cord-015021-pol2qm74	2396	17	reproducible	reproducible	JJ
cord-015021-pol2qm74	2396	18	decreases	decrease	NNS
cord-015021-pol2qm74	2396	19	in	in	IN
cord-015021-pol2qm74	2396	20	PAP	pap	NN
cord-015021-pol2qm74	2396	21	associated	associate	VBN
cord-015021-pol2qm74	2396	22	with	with	IN
cord-015021-pol2qm74	2396	23	an	an	DT
cord-015021-pol2qm74	2396	24	evident	evident	JJ
cord-015021-pol2qm74	2396	25	improvement	improvement	NN
cord-015021-pol2qm74	2396	26	in	in	IN
cord-015021-pol2qm74	2396	27	PAD2	PAD2	NNP
cord-015021-pol2qm74	2396	28	,	,	,
cord-015021-pol2qm74	2396	29	thus	thus	RB
cord-015021-pol2qm74	2396	30	allowing	allow	VBG
cord-015021-pol2qm74	2396	31	reduction	reduction	NN
cord-015021-pol2qm74	2396	32	of	of	IN
cord-015021-pol2qm74	2396	33	the	the	DT
cord-015021-pol2qm74	2396	34	F.O	F.O	NNP
cord-015021-pol2qm74	2396	35	2	2	CD
cord-015021-pol2qm74	2396	36	.	.	.
cord-015021-pol2qm74	2397	1	NO	no	DT
cord-015021-pol2qm74	2397	2	inhalation	inhalation	NN
cord-015021-pol2qm74	2397	3	should	should	MD
cord-015021-pol2qm74	2397	4	be	be	VB
cord-015021-pol2qm74	2397	5	performed	perform	VBN
cord-015021-pol2qm74	2397	6	using	use	VBG
cord-015021-pol2qm74	2397	7	low	low	JJ
cord-015021-pol2qm74	2397	8	concentrations	concentration	NNS
cord-015021-pol2qm74	2397	9	which	which	WDT
cord-015021-pol2qm74	2397	10	are	be	VBP
cord-015021-pol2qm74	2397	11	less	less	RBR
cord-015021-pol2qm74	2397	12	toxic	toxic	JJ
cord-015021-pol2qm74	2397	13	,	,	,
cord-015021-pol2qm74	2397	14	although	although	IN
cord-015021-pol2qm74	2397	15	any	any	DT
cord-015021-pol2qm74	2397	16	possible	possible	JJ
cord-015021-pol2qm74	2397	17	risks	risk	NNS
cord-015021-pol2qm74	2397	18	still	still	RB
cord-015021-pol2qm74	2397	19	have	have	VBP
cord-015021-pol2qm74	2397	20	to	to	TO
cord-015021-pol2qm74	2397	21	be	be	VB
cord-015021-pol2qm74	2397	22	considered	consider	VBN
cord-015021-pol2qm74	2397	23	carefully	carefully	RB
cord-015021-pol2qm74	2397	24	.	.	.
cord-015021-pol2qm74	2398	1	Dose	dose	JJ
cord-015021-pol2qm74	2398	2	-	-	HYPH
cord-015021-pol2qm74	2398	3	response	response	NN
cord-015021-pol2qm74	2398	4	studies	study	NNS
cord-015021-pol2qm74	2398	5	for	for	IN
cord-015021-pol2qm74	2398	6	the	the	DT
cord-015021-pol2qm74	2398	7	individual	individual	JJ
cord-015021-pol2qm74	2398	8	patients	patient	NNS
cord-015021-pol2qm74	2398	9	are	be	VBP
cord-015021-pol2qm74	2398	10	recommended	recommend	VBN
cord-015021-pol2qm74	2398	11	urgently	urgently	RB
cord-015021-pol2qm74	2398	12	.	.	.
cord-015021-pol2qm74	2399	1	Finally	finally	RB
cord-015021-pol2qm74	2399	2	,	,	,
cord-015021-pol2qm74	2399	3	controlled	control	VBN
cord-015021-pol2qm74	2399	4	randomized	randomized	JJ
cord-015021-pol2qm74	2399	5	studies	study	NNS
cord-015021-pol2qm74	2399	6	are	be	VBP
cord-015021-pol2qm74	2399	7	required	require	VBN
cord-015021-pol2qm74	2399	8	to	to	TO
cord-015021-pol2qm74	2399	9	demonstrate	demonstrate	VB
cord-015021-pol2qm74	2399	10	that	that	IN
cord-015021-pol2qm74	2399	11	additional	additional	JJ
cord-015021-pol2qm74	2399	12	NO	no	DT
cord-015021-pol2qm74	2399	13	inhalation	inhalation	NN
cord-015021-pol2qm74	2399	14	is	be	VBZ
cord-015021-pol2qm74	2399	15	able	able	JJ
cord-015021-pol2qm74	2399	16	to	to	TO
cord-015021-pol2qm74	2399	17	reduce	reduce	VB
cord-015021-pol2qm74	2399	18	mortality	mortality	NN
cord-015021-pol2qm74	2399	19	of	of	IN
cord-015021-pol2qm74	2399	20	ARDS	ARDS	NNP
cord-015021-pol2qm74	2399	21	.	.	.
cord-015021-pol2qm74	2400	1	Inhibition	inhibition	NN
cord-015021-pol2qm74	2400	2	of	of	IN
cord-015021-pol2qm74	2400	3	the	the	DT
cord-015021-pol2qm74	2400	4	activity	activity	NN
cord-015021-pol2qm74	2400	5	of	of	IN
cord-015021-pol2qm74	2400	6	glyceraldehyd-3-phosphate	glyceraldehyd-3-phosphate	JJ
cord-015021-pol2qm74	2400	7	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	2400	8	(	(	-LRB-
cord-015021-pol2qm74	2400	9	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2400	10	)	)	-RRB-
cord-015021-pol2qm74	2400	11	,	,	,
cord-015021-pol2qm74	2400	12	an	an	DT
cord-015021-pol2qm74	2400	13	enzyme	enzyme	NN
cord-015021-pol2qm74	2400	14	of	of	IN
cord-015021-pol2qm74	2400	15	the	the	DT
cord-015021-pol2qm74	2400	16	glycolysis	glycolysis	NN
cord-015021-pol2qm74	2400	17	/	/	SYM
cord-015021-pol2qm74	2400	18	gluconeogenetic	gluconeogenetic	NNP
cord-015021-pol2qm74	2400	19	pathway	pathway	NN
cord-015021-pol2qm74	2400	20	,	,	,
cord-015021-pol2qm74	2400	21	through	through	IN
cord-015021-pol2qm74	2400	22	ADP	adp	NN
cord-015021-pol2qm74	2400	23	-	-	HYPH
cord-015021-pol2qm74	2400	24	ribosylation	ribosylation	NN
cord-015021-pol2qm74	2400	25	is	be	VBZ
cord-015021-pol2qm74	2400	26	promoted	promote	VBN
cord-015021-pol2qm74	2400	27	by	by	IN
cord-015021-pol2qm74	2400	28	nitric	nitric	NN
cord-015021-pol2qm74	2400	29	oxide	oxide	NN
cord-015021-pol2qm74	2400	30	(	(	-LRB-
cord-015021-pol2qm74	2400	31	NO	no	RB
cord-015021-pol2qm74	2400	32	)	)	-RRB-
cord-015021-pol2qm74	2400	33	.	.	.
cord-015021-pol2qm74	2401	1	Since	since	IN
cord-015021-pol2qm74	2401	2	NO	no	DT
cord-015021-pol2qm74	2401	3	is	be	VBZ
cord-015021-pol2qm74	2401	4	produced	produce	VBN
cord-015021-pol2qm74	2401	5	in	in	IN
cord-015021-pol2qm74	2401	6	the	the	DT
cord-015021-pol2qm74	2401	7	septic	septic	JJ
cord-015021-pol2qm74	2401	8	liver	liver	NN
cord-015021-pol2qm74	2401	9	and	and	CC
cord-015021-pol2qm74	2401	10	hypoglycemia	hypoglycemia	NN
cord-015021-pol2qm74	2401	11	is	be	VBZ
cord-015021-pol2qm74	2401	12	a	a	DT
cord-015021-pol2qm74	2401	13	major	major	JJ
cord-015021-pol2qm74	2401	14	problem	problem	NN
cord-015021-pol2qm74	2401	15	of	of	IN
cord-015021-pol2qm74	2401	16	late	late	JJ
cord-015021-pol2qm74	2401	17	sepsis	sepsis	NN
cord-015021-pol2qm74	2401	18	,	,	,
cord-015021-pol2qm74	2401	19	it	-PRON-	PRP
cord-015021-pol2qm74	2401	20	was	be	VBD
cord-015021-pol2qm74	2401	21	investigated	investigate	VBN
cord-015021-pol2qm74	2401	22	whether	whether	IN
cord-015021-pol2qm74	2401	23	NO	no	DT
cord-015021-pol2qm74	2401	24	interferes	interfere	VBZ
cord-015021-pol2qm74	2401	25	with	with	IN
cord-015021-pol2qm74	2401	26	gluconeogenesis	gluconeogenesis	NN
cord-015021-pol2qm74	2401	27	of	of	IN
cord-015021-pol2qm74	2401	28	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	2401	29	.	.	.
cord-015021-pol2qm74	2402	1	Hepatocytes	Hepatocytes	NNP
cord-015021-pol2qm74	2402	2	(	(	-LRB-
cord-015021-pol2qm74	2402	3	HC	HC	NNP
cord-015021-pol2qm74	2402	4	)	)	-RRB-
cord-015021-pol2qm74	2402	5	were	be	VBD
cord-015021-pol2qm74	2402	6	isolated	isolate	VBN
cord-015021-pol2qm74	2402	7	from	from	IN
cord-015021-pol2qm74	2402	8	Sprague	Sprague	NNP
cord-015021-pol2qm74	2402	9	-	-	HYPH
cord-015021-pol2qm74	2402	10	Dawley	Dawley	NNP
cord-015021-pol2qm74	2402	11	rats	rat	NNS
cord-015021-pol2qm74	2402	12	using	use	VBG
cord-015021-pol2qm74	2402	13	a	a	DT
cord-015021-pol2qm74	2402	14	collagenase	collagenase	NN
cord-015021-pol2qm74	2402	15	perfusion	perfusion	NN
cord-015021-pol2qm74	2402	16	technique	technique	NN
cord-015021-pol2qm74	2402	17	and	and	CC
cord-015021-pol2qm74	2402	18	differential	differential	JJ
cord-015021-pol2qm74	2402	19	centrifugation	centrifugation	NN
cord-015021-pol2qm74	2402	20	.	.	.
cord-015021-pol2qm74	2403	1	Exogenous	exogenous	JJ
cord-015021-pol2qm74	2403	2	NO	NO	NNP
cord-015021-pol2qm74	2403	3	was	be	VBD
cord-015021-pol2qm74	2403	4	applied	apply	VBN
cord-015021-pol2qm74	2403	5	by	by	IN
cord-015021-pol2qm74	2403	6	incubation	incubation	NN
cord-015021-pol2qm74	2403	7	with	with	IN
cord-015021-pol2qm74	2403	8	the	the	DT
cord-015021-pol2qm74	2403	9	NO	NO	NNP
cord-015021-pol2qm74	2403	10	-	-	HYPH
cord-015021-pol2qm74	2403	11	donors	donor	NNS
cord-015021-pol2qm74	2403	12	S	s	NN
cord-015021-pol2qm74	2403	13	-	-	HYPH
cord-015021-pol2qm74	2403	14	nitrosyl	nitrosyl	NNP
cord-015021-pol2qm74	2403	15	-	-	HYPH
cord-015021-pol2qm74	2403	16	acetylpenicillamine	acetylpenicillamine	NN
cord-015021-pol2qm74	2403	17	and	and	CC
cord-015021-pol2qm74	2403	18	sodium	sodium	NN
cord-015021-pol2qm74	2403	19	-	-	HYPH
cord-015021-pol2qm74	2403	20	nitroprusside	nitroprusside	RB
cord-015021-pol2qm74	2403	21	.	.	.
cord-015021-pol2qm74	2404	1	Endogenous	endogenous	JJ
cord-015021-pol2qm74	2404	2	NO	no	DT
cord-015021-pol2qm74	2404	3	synthesis	synthesis	NN
cord-015021-pol2qm74	2404	4	was	be	VBD
cord-015021-pol2qm74	2404	5	induced	induce	VBN
cord-015021-pol2qm74	2404	6	by	by	IN
cord-015021-pol2qm74	2404	7	incubation	incubation	NN
cord-015021-pol2qm74	2404	8	with	with	IN
cord-015021-pol2qm74	2404	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	2404	10	(	(	-LRB-
cord-015021-pol2qm74	2404	11	TNFcq	TNFcq	NNP
cord-015021-pol2qm74	2404	12	IL-1	IL-1	NNP
cord-015021-pol2qm74	2404	13	,	,	,
cord-015021-pol2qm74	2404	14	IFNJ	IFNJ	NNP
cord-015021-pol2qm74	2404	15	and	and	CC
cord-015021-pol2qm74	2404	16	lipopolysacchafide	lipopolysacchafide	NNP
cord-015021-pol2qm74	2404	17	(	(	-LRB-
cord-015021-pol2qm74	2404	18	LPS	LPS	NNP
cord-015021-pol2qm74	2404	19	)	)	-RRB-
cord-015021-pol2qm74	2404	20	.	.	.
cord-015021-pol2qm74	2405	1	24	24	CD
cord-015021-pol2qm74	2405	2	hrs	hrs	NN
cord-015021-pol2qm74	2405	3	later	later	RB
cord-015021-pol2qm74	2405	4	the	the	DT
cord-015021-pol2qm74	2405	5	incubation	incubation	NN
cord-015021-pol2qm74	2405	6	medium	medium	NN
cord-015021-pol2qm74	2405	7	was	be	VBD
cord-015021-pol2qm74	2405	8	changed	change	VBN
cord-015021-pol2qm74	2405	9	to	to	IN
cord-015021-pol2qm74	2405	10	a	a	DT
cord-015021-pol2qm74	2405	11	solution	solution	NN
cord-015021-pol2qm74	2405	12	containing	contain	VBG
cord-015021-pol2qm74	2405	13	lactate	lactate	NN
cord-015021-pol2qm74	2405	14	,	,	,
cord-015021-pol2qm74	2405	15	ornithine	ornithine	NN
cord-015021-pol2qm74	2405	16	,	,	,
cord-015021-pol2qm74	2405	17	lysine	lysine	NN
cord-015021-pol2qm74	2405	18	,	,	,
cord-015021-pol2qm74	2405	19	ammoniumchloride	ammoniumchloride	NN
cord-015021-pol2qm74	2405	20	and	and	CC
cord-015021-pol2qm74	2405	21	glucagon	glucagon	NN
cord-015021-pol2qm74	2405	22	for	for	IN
cord-015021-pol2qm74	2405	23	optimal	optimal	JJ
cord-015021-pol2qm74	2405	24	conditions	condition	NNS
cord-015021-pol2qm74	2405	25	of	of	IN
cord-015021-pol2qm74	2405	26	gluconeogenesis	gluconeogenesis	NN
cord-015021-pol2qm74	2405	27	.	.	.
cord-015021-pol2qm74	2406	1	After	after	IN
cord-015021-pol2qm74	2406	2	3	3	CD
cord-015021-pol2qm74	2406	3	more	more	JJR
cord-015021-pol2qm74	2406	4	hrs	hrs	NN
cord-015021-pol2qm74	2406	5	glucose	glucose	NN
cord-015021-pol2qm74	2406	6	and	and	CC
cord-015021-pol2qm74	2406	7	nitrite	nitrite	NN
cord-015021-pol2qm74	2406	8	levels	level	NNS
cord-015021-pol2qm74	2406	9	were	be	VBD
cord-015021-pol2qm74	2406	10	determined	determine	VBN
cord-015021-pol2qm74	2406	11	spectrophotometrically	spectrophotometrically	RB
cord-015021-pol2qm74	2406	12	.	.	.
cord-015021-pol2qm74	2407	1	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2407	2	activity	activity	NN
cord-015021-pol2qm74	2407	3	was	be	VBD
cord-015021-pol2qm74	2407	4	measured	measure	VBN
cord-015021-pol2qm74	2407	5	by	by	IN
cord-015021-pol2qm74	2407	6	the	the	DT
cord-015021-pol2qm74	2407	7	NADH	NADH	NNP
cord-015021-pol2qm74	2407	8	-	-	HYPH
cord-015021-pol2qm74	2407	9	dependent	dependent	JJ
cord-015021-pol2qm74	2407	10	conversion	conversion	NN
cord-015021-pol2qm74	2407	11	of	of	IN
cord-015021-pol2qm74	2407	12	1,3-diphosphoglycerate	1,3-diphosphoglycerate	CD
cord-015021-pol2qm74	2407	13	to	to	IN
cord-015021-pol2qm74	2407	14	glyceraldehyde-3-phosphate	glyceraldehyde-3-phosphate	NNP
cord-015021-pol2qm74	2407	15	.	.	.
cord-015021-pol2qm74	2408	1	Incubation	Incubation	NNP
cord-015021-pol2qm74	2408	2	of	of	IN
cord-015021-pol2qm74	2408	3	HC	HC	NNP
cord-015021-pol2qm74	2408	4	with	with	IN
cord-015021-pol2qm74	2408	5	NO	no	DT
cord-015021-pol2qm74	2408	6	-	-	HYPH
cord-015021-pol2qm74	2408	7	donors	donor	NNS
cord-015021-pol2qm74	2408	8	led	lead	VBD
cord-015021-pol2qm74	2408	9	to	to	IN
cord-015021-pol2qm74	2408	10	a	a	DT
cord-015021-pol2qm74	2408	11	concentrationdependent	concentrationdependent	NN
cord-015021-pol2qm74	2408	12	inhibition	inhibition	NN
cord-015021-pol2qm74	2408	13	of	of	IN
cord-015021-pol2qm74	2408	14	gluconeogenesis	gluconeogenesis	NN
cord-015021-pol2qm74	2408	15	and	and	CC
cord-015021-pol2qm74	2408	16	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2408	17	activity	activity	NN
cord-015021-pol2qm74	2408	18	.	.	.
cord-015021-pol2qm74	2409	1	However	however	RB
cord-015021-pol2qm74	2409	2	,	,	,
cord-015021-pol2qm74	2409	3	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2409	4	activity	activity	NN
cord-015021-pol2qm74	2409	5	was	be	VBD
cord-015021-pol2qm74	2409	6	about	about	RB
cord-015021-pol2qm74	2409	7	5	5	CD
cord-015021-pol2qm74	2409	8	times	time	NNS
cord-015021-pol2qm74	2409	9	more	more	RBR
cord-015021-pol2qm74	2409	10	sensitive	sensitive	JJ
cord-015021-pol2qm74	2409	11	to	to	IN
cord-015021-pol2qm74	2409	12	the	the	DT
cord-015021-pol2qm74	2409	13	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	2409	14	effect	effect	NN
cord-015021-pol2qm74	2409	15	of	of	IN
cord-015021-pol2qm74	2409	16	exogenous	exogenous	JJ
cord-015021-pol2qm74	2409	17	NO	no	NN
cord-015021-pol2qm74	2409	18	.	.	.
cord-015021-pol2qm74	2409	19	incubation	incubation	NN
cord-015021-pol2qm74	2409	20	of	of	IN
cord-015021-pol2qm74	2409	21	HC	HC	NNP
cord-015021-pol2qm74	2409	22	with	with	IN
cord-015021-pol2qm74	2409	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	2409	24	and	and	CC
cord-015021-pol2qm74	2409	25	LPS	LPS	NNP
cord-015021-pol2qm74	2409	26	induced	induce	VBD
cord-015021-pol2qm74	2409	27	NQ	NQ	NNP
cord-015021-pol2qm74	2409	28	synthesis	synthesis	NN
cord-015021-pol2qm74	2409	29	as	as	IN
cord-015021-pol2qm74	2409	30	measured	measure	VBN
cord-015021-pol2qm74	2409	31	by	by	IN
cord-015021-pol2qm74	2409	32	an	an	DT
cord-015021-pol2qm74	2409	33	increase	increase	NN
cord-015021-pol2qm74	2409	34	in	in	IN
cord-015021-pol2qm74	2409	35	nitrite	nitrite	NN
cord-015021-pol2qm74	2409	36	concentrations	concentration	NNS
cord-015021-pol2qm74	2409	37	.	.	.
cord-015021-pol2qm74	2410	1	Endogenously	Endogenously	NNP
cord-015021-pol2qm74	2410	2	produced	produce	VBD
cord-015021-pol2qm74	2410	3	NO	no	DT
cord-015021-pol2qm74	2410	4	suppressed	suppress	VBN
cord-015021-pol2qm74	2410	5	gluconeogenesis	gluconeogenesis	NN
cord-015021-pol2qm74	2410	6	by	by	IN
cord-015021-pol2qm74	2410	7	49_+3	49_+3	CD
cord-015021-pol2qm74	2410	8	%	%	NN
cord-015021-pol2qm74	2410	9	.	.	.
cord-015021-pol2qm74	2411	1	In	in	IN
cord-015021-pol2qm74	2411	2	contrast	contrast	NN
cord-015021-pol2qm74	2411	3	to	to	IN
cord-015021-pol2qm74	2411	4	exogenously	exogenously	RB
cord-015021-pol2qm74	2411	5	applied	apply	VBN
cord-015021-pol2qm74	2411	6	NO	no	RB
cord-015021-pol2qm74	2411	7	,	,	,
cord-015021-pol2qm74	2411	8	the	the	DT
cord-015021-pol2qm74	2411	9	effect	effect	NN
cord-015021-pol2qm74	2411	10	of	of	IN
cord-015021-pol2qm74	2411	11	endogenous	endogenous	JJ
cord-015021-pol2qm74	2411	12	NO	no	DT
cord-015021-pol2qm74	2411	13	synthesis	synthesis	NN
cord-015021-pol2qm74	2411	14	was	be	VBD
cord-015021-pol2qm74	2411	15	less	less	JJR
cord-015021-pol2qm74	2411	16	on	on	IN
cord-015021-pol2qm74	2411	17	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2411	18	activity	activity	NN
cord-015021-pol2qm74	2411	19	resulting	result	VBG
cord-015021-pol2qm74	2411	20	in	in	IN
cord-015021-pol2qm74	2411	21	an	an	DT
cord-015021-pol2qm74	2411	22	inhibition	inhibition	NN
cord-015021-pol2qm74	2411	23	of	of	IN
cord-015021-pol2qm74	2411	24	only	only	RB
cord-015021-pol2qm74	2411	25	32_+12	32_+12	CD
cord-015021-pol2qm74	2411	26	%	%	NN
cord-015021-pol2qm74	2411	27	.	.	.
cord-015021-pol2qm74	2412	1	In	in	IN
cord-015021-pol2qm74	2412	2	conclusion	conclusion	NN
cord-015021-pol2qm74	2412	3	,	,	,
cord-015021-pol2qm74	2412	4	exogenous	exogenous	JJ
cord-015021-pol2qm74	2412	5	and	and	CC
cord-015021-pol2qm74	2412	6	endogenous	endogenous	JJ
cord-015021-pol2qm74	2412	7	NO	no	DT
cord-015021-pol2qm74	2412	8	inhibited	inhibited	JJ
cord-015021-pol2qm74	2412	9	gluconeogenesis	gluconeogenesis	NN
cord-015021-pol2qm74	2412	10	as	as	RB
cord-015021-pol2qm74	2412	11	well	well	RB
cord-015021-pol2qm74	2412	12	as	as	IN
cord-015021-pol2qm74	2412	13	GAPDH	GAPDH	NNP
cord-015021-pol2qm74	2412	14	activity	activity	NN
cord-015021-pol2qm74	2412	15	.	.	.
cord-015021-pol2qm74	2413	1	However	however	RB
cord-015021-pol2qm74	2413	2	,	,	,
cord-015021-pol2qm74	2413	3	there	there	EX
cord-015021-pol2qm74	2413	4	was	be	VBD
cord-015021-pol2qm74	2413	5	no	no	DT
cord-015021-pol2qm74	2413	6	correlation	correlation	NN
cord-015021-pol2qm74	2413	7	between	between	IN
cord-015021-pol2qm74	2413	8	the	the	DT
cord-015021-pol2qm74	2413	9	extent	extent	NN
cord-015021-pol2qm74	2413	10	of	of	IN
cord-015021-pol2qm74	2413	11	inhibition	inhibition	NN
cord-015021-pol2qm74	2413	12	of	of	IN
cord-015021-pol2qm74	2413	13	these	these	DT
cord-015021-pol2qm74	2413	14	two	two	CD
cord-015021-pol2qm74	2413	15	parameters	parameter	NNS
cord-015021-pol2qm74	2413	16	of	of	IN
cord-015021-pol2qm74	2413	17	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	2413	18	glucose	glucose	NN
cord-015021-pol2qm74	2413	19	metabolism	metabolism	NN
cord-015021-pol2qm74	2413	20	.	.	.
cord-015021-pol2qm74	2414	1	We	-PRON-	PRP
cord-015021-pol2qm74	2414	2	have	have	VBP
cord-015021-pol2qm74	2414	3	shown	show	VBN
cord-015021-pol2qm74	2414	4	that	that	DT
cord-015021-pol2qm74	2414	5	inhibition	inhibition	NN
cord-015021-pol2qm74	2414	6	of	of	IN
cord-015021-pol2qm74	2414	7	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	2414	8	(	(	-LRB-
cord-015021-pol2qm74	2414	9	HEP	HEP	NNP
cord-015021-pol2qm74	2414	10	)	)	-RRB-
cord-015021-pol2qm74	2414	11	synthesis	synthesis	NN
cord-015021-pol2qm74	2414	12	of	of	IN
cord-015021-pol2qm74	2414	13	nitric	nitric	NN
cord-015021-pol2qm74	2414	14	oxide	oxide	NN
cord-015021-pol2qm74	2414	15	(	(	-LRB-
cord-015021-pol2qm74	2414	16	NO	no	UH
cord-015021-pol2qm74	2414	17	)	)	-RRB-
cord-015021-pol2qm74	2414	18	potentiates	potentiate	VBZ
cord-015021-pol2qm74	2414	19	cell	cell	NN
cord-015021-pol2qm74	2414	20	injury	injury	NN
cord-015021-pol2qm74	2414	21	in	in	IN
cord-015021-pol2qm74	2414	22	a	a	DT
cord-015021-pol2qm74	2414	23	model	model	NN
cord-015021-pol2qm74	2414	24	of	of	IN
cord-015021-pol2qm74	2414	25	acetaminopheninduced	acetaminopheninduced	JJ
cord-015021-pol2qm74	2414	26	oxidative	oxidative	JJ
cord-015021-pol2qm74	2414	27	stress	stress	NN
cord-015021-pol2qm74	2414	28	and	and	CC
cord-015021-pol2qm74	2414	29	the	the	DT
cord-015021-pol2qm74	2414	30	extent	extent	NN
cord-015021-pol2qm74	2414	31	of	of	IN
cord-015021-pol2qm74	2414	32	damage	damage	NN
cord-015021-pol2qm74	2414	33	was	be	VBD
cord-015021-pol2qm74	2414	34	paralleled	parallel	VBN
cord-015021-pol2qm74	2414	35	by	by	IN
cord-015021-pol2qm74	2414	36	depletion	depletion	NN
cord-015021-pol2qm74	2414	37	of	of	IN
cord-015021-pol2qm74	2414	38	reduced	reduce	VBN
cord-015021-pol2qm74	2414	39	glutathione	glutathione	NN
cord-015021-pol2qm74	2414	40	(	(	-LRB-
cord-015021-pol2qm74	2414	41	GSH	GSH	NNP
cord-015021-pol2qm74	2414	42	)	)	-RRB-
cord-015021-pol2qm74	2414	43	stores	store	NNS
cord-015021-pol2qm74	2414	44	.	.	.
cord-015021-pol2qm74	2415	1	To	to	TO
cord-015021-pol2qm74	2415	2	clarify	clarify	VB
cord-015021-pol2qm74	2415	3	the	the	DT
cord-015021-pol2qm74	2415	4	role	role	NN
cord-015021-pol2qm74	2415	5	of	of	IN
cord-015021-pol2qm74	2415	6	NO	no	DT
cord-015021-pol2qm74	2415	7	in	in	IN
cord-015021-pol2qm74	2415	8	modulating	modulate	VBG
cord-015021-pol2qm74	2415	9	the	the	DT
cord-015021-pol2qm74	2415	10	redox	redox	JJ
cord-015021-pol2qm74	2415	11	state	state	NN
cord-015021-pol2qm74	2415	12	of	of	IN
cord-015021-pol2qm74	2415	13	HEP	HEP	NNP
cord-015021-pol2qm74	2415	14	,	,	,
cord-015021-pol2qm74	2415	15	we	-PRON-	PRP
cord-015021-pol2qm74	2415	16	studied	study	VBD
cord-015021-pol2qm74	2415	17	the	the	DT
cord-015021-pol2qm74	2415	18	effect	effect	NN
cord-015021-pol2qm74	2415	19	of	of	IN
cord-015021-pol2qm74	2415	20	inhibition	inhibition	NN
cord-015021-pol2qm74	2415	21	of	of	IN
cord-015021-pol2qm74	2415	22	cytokine	cytokine	NN
cord-015021-pol2qm74	2415	23	-	-	HYPH
cord-015021-pol2qm74	2415	24	mediated	mediate	VBN
cord-015021-pol2qm74	2415	25	NO	no	DT
cord-015021-pol2qm74	2415	26	production	production	NN
cord-015021-pol2qm74	2415	27	on	on	IN
cord-015021-pol2qm74	2415	28	HEP	HEP	NNP
cord-015021-pol2qm74	2415	29	GSH	GSH	NNP
cord-015021-pol2qm74	2415	30	stores	store	NNS
cord-015021-pol2qm74	2415	31	,	,	,
cord-015021-pol2qm74	2415	32	in	in	IN
cord-015021-pol2qm74	2415	33	a	a	DT
cord-015021-pol2qm74	2415	34	system	system	NN
cord-015021-pol2qm74	2415	35	of	of	IN
cord-015021-pol2qm74	2415	36	isolated	isolate	VBN
cord-015021-pol2qm74	2415	37	rat	rat	NN
cord-015021-pol2qm74	2415	38	HEP	hep	NN
cord-015021-pol2qm74	2415	39	in	in	IN
cord-015021-pol2qm74	2415	40	primary	primary	JJ
cord-015021-pol2qm74	2415	41	culture	culture	NN
cord-015021-pol2qm74	2415	42	,	,	,
cord-015021-pol2qm74	2415	43	NO	no	DT
cord-015021-pol2qm74	2415	44	synthesis	synthesis	NN
cord-015021-pol2qm74	2415	45	was	be	VBD
cord-015021-pol2qm74	2415	46	induced	induce	VBN
cord-015021-pol2qm74	2415	47	(	(	-LRB-
cord-015021-pol2qm74	2415	48	STIM	STIM	NNP
cord-015021-pol2qm74	2415	49	)	)	-RRB-
cord-015021-pol2qm74	2415	50	by	by	IN
cord-015021-pol2qm74	2415	51	exposure	exposure	NN
cord-015021-pol2qm74	2415	52	to	to	IN
cord-015021-pol2qm74	2415	53	IL-1	IL-1	NNP
cord-015021-pol2qm74	2415	54	,	,	,
cord-015021-pol2qm74	2415	55	TNF	TNF	NNP
cord-015021-pol2qm74	2415	56	,	,	,
cord-015021-pol2qm74	2415	57	IFN	IFN	NNP
cord-015021-pol2qm74	2415	58	,	,	,
cord-015021-pol2qm74	2415	59	and	and	CC
cord-015021-pol2qm74	2415	60	LPS	LPS	NNP
cord-015021-pol2qm74	2415	61	for	for	IN
cord-015021-pol2qm74	2415	62	16	16	CD
cord-015021-pol2qm74	2415	63	hours	hour	NNS
cord-015021-pol2qm74	2415	64	.	.	.
cord-015021-pol2qm74	2416	1	20	20	CD
cord-015021-pol2qm74	2416	2	,	,	,
cord-015021-pol2qm74	2416	3	60	60	CD
cord-015021-pol2qm74	2416	4	,	,	,
cord-015021-pol2qm74	2416	5	120	120	CD
cord-015021-pol2qm74	2416	6	and	and	CC
cord-015021-pol2qm74	2416	7	200	200	CD
cord-015021-pol2qm74	2416	8	~M	~M	NFP
cord-015021-pol2qm74	2416	9	of	of	IN
cord-015021-pol2qm74	2416	10	N	n	CD
cord-015021-pol2qm74	2416	11	-	-	HYPH
cord-015021-pol2qm74	2416	12	monomethyI	monomethyI	NNP
cord-015021-pol2qm74	2416	13	-	-	HYPH
cord-015021-pol2qm74	2416	14	L	l	NN
cord-015021-pol2qm74	2416	15	-	-	HYPH
cord-015021-pol2qm74	2416	16	arginine	arginine	NN
cord-015021-pol2qm74	2416	17	(	(	-LRB-
cord-015021-pol2qm74	2416	18	NMMA	NMMA	NNP
cord-015021-pol2qm74	2416	19	)	)	-RRB-
cord-015021-pol2qm74	2416	20	,	,	,
cord-015021-pol2qm74	2416	21	a	a	DT
cord-015021-pol2qm74	2416	22	specific	specific	JJ
cord-015021-pol2qm74	2416	23	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2416	24	of	of	IN
cord-015021-pol2qm74	2416	25	NO	no	DT
cord-015021-pol2qm74	2416	26	synthesis	synthesis	NN
cord-015021-pol2qm74	2416	27	,	,	,
cord-015021-pol2qm74	2416	28	was	be	VBD
cord-015021-pol2qm74	2416	29	added	add	VBN
cord-015021-pol2qm74	2416	30	.	.	.
cord-015021-pol2qm74	2417	1	Cells	cell	NNS
cord-015021-pol2qm74	2417	2	incubated	incubate	VBN
cord-015021-pol2qm74	2417	3	in	in	IN
cord-015021-pol2qm74	2417	4	media	medium	NNS
cord-015021-pol2qm74	2417	5	alone	alone	RB
cord-015021-pol2qm74	2417	6	served	serve	VBD
cord-015021-pol2qm74	2417	7	as	as	IN
cord-015021-pol2qm74	2417	8	controls	control	NNS
cord-015021-pol2qm74	2417	9	(	(	-LRB-
cord-015021-pol2qm74	2417	10	CONT	CONT	NNP
cord-015021-pol2qm74	2417	11	)	)	-RRB-
cord-015021-pol2qm74	2417	12	.	.	.
cord-015021-pol2qm74	2418	1	The	the	DT
cord-015021-pol2qm74	2418	2	NO	no	DT
cord-015021-pol2qm74	2418	3	metabolite	metabolite	NN
cord-015021-pol2qm74	2418	4	(	(	-LRB-
cord-015021-pol2qm74	2418	5	NO2	NO2	NNP
cord-015021-pol2qm74	2418	6	)	)	-RRB-
cord-015021-pol2qm74	2418	7	;	;	:
cord-015021-pol2qm74	2418	8	aspartate	aspartate	NNP
cord-015021-pol2qm74	2418	9	aminotransferase	aminotransferase	NN
cord-015021-pol2qm74	2418	10	(	(	-LRB-
cord-015021-pol2qm74	2418	11	AST	AST	NNP
cord-015021-pol2qm74	2418	12	)	)	-RRB-
cord-015021-pol2qm74	2418	13	,	,	,
cord-015021-pol2qm74	2418	14	an	an	DT
cord-015021-pol2qm74	2418	15	indicator	indicator	NN
cord-015021-pol2qm74	2418	16	of	of	IN
cord-015021-pol2qm74	2418	17	cell	cell	NN
cord-015021-pol2qm74	2418	18	injury	injury	NN
cord-015021-pol2qm74	2418	19	;	;	,
cord-015021-pol2qm74	2418	20	and	and	CC
cord-015021-pol2qm74	2418	21	GSH	GSH	NNP
cord-015021-pol2qm74	2418	22	were	be	VBD
cord-015021-pol2qm74	2418	23	assayed	assay	VBN
cord-015021-pol2qm74	2418	24	.	.	.
cord-015021-pol2qm74	2419	1	(	(	-LRB-
cord-015021-pol2qm74	2419	2	Data	datum	NNS
cord-015021-pol2qm74	2419	3	presented	present	VBN
cord-015021-pol2qm74	2419	4	as	as	IN
cord-015021-pol2qm74	2419	5	mean	mean	JJ
cord-015021-pol2qm74	2419	6	+	+	CC
cord-015021-pol2qm74	2419	7	SEM	sem	NN
cord-015021-pol2qm74	2419	8	;	;	,
cord-015021-pol2qm74	2419	9	n=4	n=4	JJ
cord-015021-pol2qm74	2419	10	.	.	.
cord-015021-pol2qm74	2419	11	)	)	-RRB-
cord-015021-pol2qm74	2420	1	GSH	GSH	NNP
cord-015021-pol2qm74	2420	2	(	(	-LRB-
cord-015021-pol2qm74	2420	3	nmoVma	nmoVma	NNP
cord-015021-pol2qm74	2420	4	orotein	orotein	NNP
cord-015021-pol2qm74	2420	5	)	)	-RRB-
cord-015021-pol2qm74	2420	6	..	..	.
cord-015021-pol2qm74	2421	1	~	~	NFP
cord-015021-pol2qm74	2421	2	(	(	-LRB-
cord-015021-pol2qm74	2421	3	nmol	nmol	NNP
cord-015021-pol2qm74	2421	4	/	/	SYM
cord-015021-pol2qm74	2421	5	ma	ma	NNP
cord-015021-pol2qm74	2421	6	orotein	orotein	NNP
cord-015021-pol2qm74	2421	7	)	)	-RRB-
cord-015021-pol2qm74	2421	8	CONT	CONT	NNP
cord-015021-pol2qm74	2421	9	14.1	14.1	CD
cord-015021-pol2qm74	2421	10	+	+	SYM
cord-015021-pol2qm74	2421	11	0.3	0.3	CD
cord-015021-pol2qm74	2421	12	32	32	CD
cord-015021-pol2qm74	2421	13	+	+	SYM
cord-015021-pol2qm74	2421	14	4.0	4.0	CD
cord-015021-pol2qm74	2421	15	#	#	NN
cord-015021-pol2qm74	2421	16	STIM	STIM	NNP
cord-015021-pol2qm74	2421	17	13.4	13.4	CD
cord-015021-pol2qm74	2421	18	+	+	SYM
cord-015021-pol2qm74	2421	19	0.6	0.6	CD
cord-015021-pol2qm74	2421	20	139	139	CD
cord-015021-pol2qm74	2421	21	+	+	CD
cord-015021-pol2qm74	2422	1	12	12	CD
cord-015021-pol2qm74	2422	2	STIM+2O	STIM+2O	NNS
cord-015021-pol2qm74	2422	3	tzM	tzM	NNP
cord-015021-pol2qm74	2422	4	NMMA	NMMA	NNP
cord-015021-pol2qm74	2422	5	12.7	12.7	CD
cord-015021-pol2qm74	2422	6	+	+	SYM
cord-015021-pol2qm74	2422	7	1.1	1.1	CD
cord-015021-pol2qm74	2422	8	88	88	CD
cord-015021-pol2qm74	2422	9	+	+	SYM
cord-015021-pol2qm74	2422	10	5.0	5.0	CD
cord-015021-pol2qm74	2422	11	#	#	NN
cord-015021-pol2qm74	2422	12	STIM+60	stim+60	NN
cord-015021-pol2qm74	2423	1	~M	~M	NFP
cord-015021-pol2qm74	2423	2	NMMA	NMMA	NNP
cord-015021-pol2qm74	2423	3	9.9	9.9	CD
cord-015021-pol2qm74	2423	4	_	_	NNP
cord-015021-pol2qm74	2423	5	..	..	.
cord-015021-pol2qm74	2424	1	+	+	CC
cord-015021-pol2qm74	2424	2	0.4	0.4	CD
cord-015021-pol2qm74	2424	3	*	*	NFP
cord-015021-pol2qm74	2424	4	68	68	CD
cord-015021-pol2qm74	2424	5	+	+	SYM
cord-015021-pol2qm74	2424	6	4.5	4.5	CD
cord-015021-pol2qm74	2424	7	#	#	NN
cord-015021-pol2qm74	2424	8	STIM+120	stim+120	CD
cord-015021-pol2qm74	2424	9	pM	pm	NN
cord-015021-pol2qm74	2424	10	NMMA	NMMA	NNP
cord-015021-pol2qm74	2424	11	7.6	7.6	CD
cord-015021-pol2qm74	2424	12	+	+	SYM
cord-015021-pol2qm74	2424	13	0.6	0.6	CD
cord-015021-pol2qm74	2424	14	*	*	NFP
cord-015021-pol2qm74	2424	15	57	57	CD
cord-015021-pol2qm74	2424	16	+	+	SYM
cord-015021-pol2qm74	2424	17	3.0	3.0	CD
cord-015021-pol2qm74	2424	18	#	#	NN
cord-015021-pol2qm74	2424	19	STIM+200	stim+200	CD
cord-015021-pol2qm74	2424	20	)	)	-RRB-
cord-015021-pol2qm74	2425	1	lM	lM	NNP
cord-015021-pol2qm74	2426	1	NMMA	NMMA	NNP
cord-015021-pol2qm74	2426	2	5.0	5.0	CD
cord-015021-pol2qm74	2426	3	+	+	SYM
cord-015021-pol2qm74	2426	4	0.5	0.5	CD
cord-015021-pol2qm74	2427	1	*	*	NFP
cord-015021-pol2qm74	2427	2	37	37	CD
cord-015021-pol2qm74	2427	3	+	+	SYM
cord-015021-pol2qm74	2427	4	2.5	2.5	CD
cord-015021-pol2qm74	2427	5	#	#	NN
cord-015021-pol2qm74	2427	6	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	2428	1	0,0002	0,0002	$
cord-015021-pol2qm74	2428	2	0.0001	0.0001	CD
cord-015021-pol2qm74	2429	1	(	(	-LRB-
cord-015021-pol2qm74	2429	2	*	*	NFP
cord-015021-pol2qm74	2429	3	p	p	XX
cord-015021-pol2qm74	2429	4	<	<	XX
cord-015021-pol2qm74	2429	5	0.05	0.05	CD
cord-015021-pol2qm74	2429	6	versus	versus	IN
cord-015021-pol2qm74	2429	7	STIM	STIM	NNP
cord-015021-pol2qm74	2429	8	,	,	,
cord-015021-pol2qm74	2429	9	#	#	NN
cord-015021-pol2qm74	2429	10	p	p	NN
cord-015021-pol2qm74	2429	11	<	<	XX
cord-015021-pol2qm74	2429	12	0.01	0.01	CD
cord-015021-pol2qm74	2429	13	versus	versus	IN
cord-015021-pol2qm74	2429	14	STIM	STIM	NNP
cord-015021-pol2qm74	2429	15	;	;	:
cord-015021-pol2qm74	2429	16	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	2429	17	with	with	IN
cord-015021-pol2qm74	2429	18	Neuman	Neuman	NNP
cord-015021-pol2qm74	2429	19	-	-	HYPH
cord-015021-pol2qm74	2429	20	Keuls	Keuls	NNP
cord-015021-pol2qm74	2429	21	)	)	-RRB-
cord-015021-pol2qm74	2429	22	GSH	GSH	NNP
cord-015021-pol2qm74	2429	23	in	in	IN
cord-015021-pol2qm74	2429	24	CONT+120	CONT+120	NNP
cord-015021-pol2qm74	2430	1	I	-PRON-	PRP
cord-015021-pol2qm74	2431	1	~M	~M	NFP
cord-015021-pol2qm74	2431	2	L	L	NNP
cord-015021-pol2qm74	2431	3	-	-	HYPH
cord-015021-pol2qm74	2431	4	NMMA	NMMA	NNP
cord-015021-pol2qm74	2431	5	was	be	VBD
cord-015021-pol2qm74	2431	6	equivalent	equivalent	JJ
cord-015021-pol2qm74	2431	7	to	to	IN
cord-015021-pol2qm74	2431	8	that	that	DT
cord-015021-pol2qm74	2431	9	of	of	IN
cord-015021-pol2qm74	2431	10	CONT	CONT	NNP
cord-015021-pol2qm74	2431	11	(	(	-LRB-
cord-015021-pol2qm74	2431	12	13.3	13.3	CD
cord-015021-pol2qm74	2431	13	vs.14.1	vs.14.1	NNP
cord-015021-pol2qm74	2431	14	)	)	-RRB-
cord-015021-pol2qm74	2431	15	.	.	.
cord-015021-pol2qm74	2432	1	AST	AST	NNP
cord-015021-pol2qm74	2432	2	release	release	NN
cord-015021-pol2qm74	2432	3	was	be	VBD
cord-015021-pol2qm74	2432	4	equivalent	equivalent	JJ
cord-015021-pol2qm74	2432	5	in	in	IN
cord-015021-pol2qm74	2432	6	all	all	DT
cord-015021-pol2qm74	2432	7	treatment	treatment	NN
cord-015021-pol2qm74	2432	8	groups	group	NNS
cord-015021-pol2qm74	2432	9	.	.	.
cord-015021-pol2qm74	2433	1	These	these	DT
cord-015021-pol2qm74	2433	2	data	datum	NNS
cord-015021-pol2qm74	2433	3	show	show	VBP
cord-015021-pol2qm74	2433	4	that	that	IN
cord-015021-pol2qm74	2433	5	inhibition	inhibition	NN
cord-015021-pol2qm74	2433	6	of	of	IN
cord-015021-pol2qm74	2433	7	HEP	HEP	NNP
cord-015021-pol2qm74	2433	8	synthesis	synthesis	NN
cord-015021-pol2qm74	2433	9	of	of	IN
cord-015021-pol2qm74	2433	10	NO	no	DT
cord-015021-pol2qm74	2433	11	depletes	deplete	VBZ
cord-015021-pol2qm74	2433	12	intracellular	intracellular	JJ
cord-015021-pol2qm74	2433	13	stores	store	NNS
cord-015021-pol2qm74	2433	14	of	of	IN
cord-015021-pol2qm74	2433	15	reduced	reduce	VBN
cord-015021-pol2qm74	2433	16	GSH	GSH	NNP
cord-015021-pol2qm74	2433	17	.	.	.
cord-015021-pol2qm74	2434	1	We	-PRON-	PRP
cord-015021-pol2qm74	2434	2	conclude	conclude	VBP
cord-015021-pol2qm74	2434	3	that	that	IN
cord-015021-pol2qm74	2434	4	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	2434	5	NO	no	DT
cord-015021-pol2qm74	2434	6	production	production	NN
cord-015021-pol2qm74	2434	7	modulates	modulate	VBZ
cord-015021-pol2qm74	2434	8	cellular	cellular	JJ
cord-015021-pol2qm74	2434	9	GSH	GSH	NNP
cord-015021-pol2qm74	2434	10	homeostasis	homeostasis	NN
cord-015021-pol2qm74	2434	11	and	and	CC
cord-015021-pol2qm74	2434	12	as	as	IN
cord-015021-pol2qm74	2434	13	a	a	DT
cord-015021-pol2qm74	2434	14	result	result	NN
cord-015021-pol2qm74	2434	15	,	,	,
cord-015021-pol2qm74	2434	16	may	may	MD
cord-015021-pol2qm74	2434	17	be	be	VB
cord-015021-pol2qm74	2434	18	hepatoprotective	hepatoprotective	JJ
cord-015021-pol2qm74	2434	19	in	in	IN
cord-015021-pol2qm74	2434	20	oxidative	oxidative	JJ
cord-015021-pol2qm74	2434	21	injury	injury	NN
cord-015021-pol2qm74	2434	22	.	.	.
cord-015021-pol2qm74	2434	23	 	 	_SP
cord-015021-pol2qm74	2435	1	Nitric	nitric	NN
cord-015021-pol2qm74	2435	2	oxide	oxide	NN
cord-015021-pol2qm74	2435	3	(	(	-LRB-
cord-015021-pol2qm74	2435	4	NO	no	UH
cord-015021-pol2qm74	2435	5	)	)	-RRB-
cord-015021-pol2qm74	2435	6	is	be	VBZ
cord-015021-pol2qm74	2435	7	a	a	DT
cord-015021-pol2qm74	2435	8	modulator	modulator	NN
cord-015021-pol2qm74	2435	9	of	of	IN
cord-015021-pol2qm74	2435	10	immune	immune	JJ
cord-015021-pol2qm74	2435	11	response	response	NN
cord-015021-pol2qm74	2435	12	and	and	CC
cord-015021-pol2qm74	2435	13	may	may	MD
cord-015021-pol2qm74	2435	14	be	be	VB
cord-015021-pol2qm74	2435	15	involved	involve	VBN
cord-015021-pol2qm74	2435	16	in	in	IN
cord-015021-pol2qm74	2435	17	thE	the	DT
cord-015021-pol2qm74	2435	18	changes	change	NNS
cord-015021-pol2qm74	2435	19	in	in	IN
cord-015021-pol2qm74	2435	20	immune	immune	JJ
cord-015021-pol2qm74	2435	21	reactivity	reactivity	NN
cord-015021-pol2qm74	2435	22	after	after	IN
cord-015021-pol2qm74	2435	23	major	major	JJ
cord-015021-pol2qm74	2435	24	trauma	trauma	NN
cord-015021-pol2qm74	2435	25	and	and	CC
cord-015021-pol2qm74	2435	26	operations	operation	NNS
cord-015021-pol2qm74	2435	27	.	.	.
cord-015021-pol2qm74	2436	1	We	-PRON-	PRP
cord-015021-pol2qm74	2436	2	investigated	investigate	VBD
cord-015021-pol2qm74	2436	3	NO	no	JJ
cord-015021-pol2qm74	2436	4	-	-	HYPH
cord-015021-pol2qm74	2436	5	generation	generation	NN
cord-015021-pol2qm74	2436	6	in	in	IN
cord-015021-pol2qm74	2436	7	rat	rat	NN
cord-015021-pol2qm74	2436	8	and	and	CC
cord-015021-pol2qm74	2436	9	mice	mice	NN
cord-015021-pol2qm74	2436	10	spleen	spleen	NN
cord-015021-pol2qm74	2436	11	cells	cell	NNS
cord-015021-pol2qm74	2436	12	(	(	-LRB-
cord-015021-pol2qm74	2436	13	SC	SC	NNP
cord-015021-pol2qm74	2436	14	)	)	-RRB-
cord-015021-pol2qm74	2436	15	after	after	IN
cord-015021-pol2qm74	2436	16	partial	partial	JJ
cord-015021-pol2qm74	2436	17	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	2436	18	(	(	-LRB-
cord-015021-pol2qm74	2436	19	PH	PH	NNP
cord-015021-pol2qm74	2436	20	)	)	-RRB-
cord-015021-pol2qm74	2436	21	.	.	.
cord-015021-pol2qm74	2437	1	C57BL/6	C57BL/6	NNP
cord-015021-pol2qm74	2437	2	mice	mouse	NNS
cord-015021-pol2qm74	2437	3	and	and	CC
cord-015021-pol2qm74	2437	4	LEW	LEW	NNP
cord-015021-pol2qm74	2437	5	rats	rat	NNS
cord-015021-pol2qm74	2437	6	underwent	undergo	VBD
cord-015021-pol2qm74	2437	7	a	a	DT
cord-015021-pol2qm74	2437	8	50	50	CD
cord-015021-pol2qm74	2437	9	%	%	NN
cord-015021-pol2qm74	2437	10	and	and	CC
cord-015021-pol2qm74	2437	11	70	70	CD
cord-015021-pol2qm74	2437	12	%	%	NN
cord-015021-pol2qm74	2437	13	PH	ph	NN
cord-015021-pol2qm74	2437	14	,	,	,
cord-015021-pol2qm74	2437	15	respectively	respectively	RB
cord-015021-pol2qm74	2437	16	.	.	.
cord-015021-pol2qm74	2438	1	SC	SC	NNP
cord-015021-pol2qm74	2438	2	were	be	VBD
cord-015021-pol2qm74	2438	3	prepared	prepared	JJ
cord-015021-pol2qm74	2438	4	1	1	CD
cord-015021-pol2qm74	2438	5	-	-	SYM
cord-015021-pol2qm74	2438	6	6	6	CD
cord-015021-pol2qm74	2438	7	days	day	NNS
cord-015021-pol2qm74	2438	8	after	after	IN
cord-015021-pol2qm74	2438	9	PH	PH	NNP
cord-015021-pol2qm74	2438	10	and	and	CC
cord-015021-pol2qm74	2438	11	plated	plate	VBD
cord-015021-pol2qm74	2438	12	at	at	IN
cord-015021-pol2qm74	2438	13	1	1	CD
cord-015021-pol2qm74	2438	14	to	to	IN
cord-015021-pol2qm74	2438	15	2	2	CD
cord-015021-pol2qm74	2438	16	x	x	SYM
cord-015021-pol2qm74	2438	17	10ecells	10ecells	CD
cord-015021-pol2qm74	2438	18	per	per	IN
cord-015021-pol2qm74	2438	19	well	well	RB
cord-015021-pol2qm74	2438	20	.	.	.
cord-015021-pol2qm74	2439	1	After	after	IN
cord-015021-pol2qm74	2439	2	20	20	CD
cord-015021-pol2qm74	2439	3	h	h	NN
cord-015021-pol2qm74	2439	4	incubation	incubation	NN
cord-015021-pol2qm74	2439	5	at	at	IN
cord-015021-pol2qm74	2439	6	37	37	CD
cord-015021-pol2qm74	2439	7	°	°	NN
cord-015021-pol2qm74	2439	8	C	c	NN
cord-015021-pol2qm74	2439	9	,	,	,
cord-015021-pol2qm74	2439	10	NO	no	JJ
cord-015021-pol2qm74	2439	11	-	-	HYPH
cord-015021-pol2qm74	2439	12	production	production	NN
cord-015021-pol2qm74	2439	13	was	be	VBD
cord-015021-pol2qm74	2439	14	measured	measure	VBN
cord-015021-pol2qm74	2439	15	as	as	IN
cord-015021-pol2qm74	2439	16	nitrite	nitrite	NN
cord-015021-pol2qm74	2439	17	levels	level	NNS
cord-015021-pol2qm74	2439	18	(	(	-LRB-
cord-015021-pol2qm74	2439	19	Griess	Griess	NNP
cord-015021-pol2qm74	2439	20	reagent	reagent	NN
cord-015021-pol2qm74	2439	21	)	)	-RRB-
cord-015021-pol2qm74	2439	22	.	.	.
cord-015021-pol2qm74	2440	1	Normal	normal	JJ
cord-015021-pol2qm74	2440	2	mouse	mouse	NN
cord-015021-pol2qm74	2440	3	SC	SC	NNP
cord-015021-pol2qm74	2440	4	did	do	VBD
cord-015021-pol2qm74	2440	5	not	not	RB
cord-015021-pol2qm74	2440	6	produce	produce	VB
cord-015021-pol2qm74	2440	7	NO	no	NN
cord-015021-pol2qm74	2440	8	,	,	,
cord-015021-pol2qm74	2440	9	neither	neither	CC
cord-015021-pol2qm74	2440	10	basal	basal	NN
cord-015021-pol2qm74	2440	11	nor	nor	CC
cord-015021-pol2qm74	2440	12	in	in	IN
cord-015021-pol2qm74	2440	13	response	response	NN
cord-015021-pol2qm74	2440	14	to	to	IN
cord-015021-pol2qm74	2440	15	LPS	LPS	NNP
cord-015021-pol2qm74	2440	16	or	or	CC
cord-015021-pol2qm74	2440	17	Con	Con	NNP
cord-015021-pol2qm74	2440	18	A	a	NN
cord-015021-pol2qm74	2441	1	Starting	start	VBG
cord-015021-pol2qm74	2441	2	at	at	IN
cord-015021-pol2qm74	2441	3	the	the	DT
cord-015021-pol2qm74	2441	4	second	second	JJ
cord-015021-pol2qm74	2441	5	day	day	NN
cord-015021-pol2qm74	2441	6	after	after	IN
cord-015021-pol2qm74	2441	7	PH	PH	NNP
cord-015021-pol2qm74	2441	8	,	,	,
cord-015021-pol2qm74	2441	9	we	-PRON-	PRP
cord-015021-pol2qm74	2441	10	found	find	VBD
cord-015021-pol2qm74	2441	11	a	a	DT
cord-015021-pol2qm74	2441	12	substantial	substantial	JJ
cord-015021-pol2qm74	2441	13	production	production	NN
cord-015021-pol2qm74	2441	14	of	of	IN
cord-015021-pol2qm74	2441	15	NO	no	NN
cord-015021-pol2qm74	2441	16	.	.	.
cord-015021-pol2qm74	2442	1	In	in	IN
cord-015021-pol2qm74	2442	2	rats	rat	NNS
cord-015021-pol2qm74	2442	3	,	,	,
cord-015021-pol2qm74	2442	4	also	also	RB
cord-015021-pol2qm74	2442	5	SC	SC	NNP
cord-015021-pol2qm74	2442	6	from	from	IN
cord-015021-pol2qm74	2442	7	control	control	NN
cord-015021-pol2qm74	2442	8	animals	animal	NNS
cord-015021-pol2qm74	2442	9	were	be	VBD
cord-015021-pol2qm74	2442	10	able	able	JJ
cord-015021-pol2qm74	2442	11	to	to	TO
cord-015021-pol2qm74	2442	12	generate	generate	VB
cord-015021-pol2qm74	2442	13	NO	no	DT
cord-015021-pol2qm74	2442	14	;	;	:
cord-015021-pol2qm74	2442	15	both	both	DT
cord-015021-pol2qm74	2442	16	basal	basal	NN
cord-015021-pol2qm74	2442	17	and	and	CC
cord-015021-pol2qm74	2442	18	stimulated	stimulate	VBD
cord-015021-pol2qm74	2442	19	NO	no	JJ
cord-015021-pol2qm74	2442	20	-	-	HYPH
cord-015021-pol2qm74	2442	21	generation	generation	NN
cord-015021-pol2qm74	2442	22	were	be	VBD
cord-015021-pol2qm74	2442	23	further	further	RB
cord-015021-pol2qm74	2442	24	enhanced	enhance	VBN
cord-015021-pol2qm74	2442	25	after	after	IN
cord-015021-pol2qm74	2442	26	PH	PH	NNP
cord-015021-pol2qm74	2442	27	(	(	-LRB-
cord-015021-pol2qm74	2442	28	Table	table	NN
cord-015021-pol2qm74	2442	29	,	,	,
cord-015021-pol2qm74	2442	30	values	value	NNS
cord-015021-pol2qm74	2442	31	expressed	express	VBN
cord-015021-pol2qm74	2442	32	as	as	IN
cord-015021-pol2qm74	2442	33	mean	mean	JJ
cord-015021-pol2qm74	2442	34	--SE	--SE	NNP
cord-015021-pol2qm74	2442	35	)	)	-RRB-
cord-015021-pol2qm74	2442	36	.	.	.
cord-015021-pol2qm74	2443	1	After	after	IN
cord-015021-pol2qm74	2443	2	shame	shame	NN
cord-015021-pol2qm74	2443	3	operation	operation	NN
cord-015021-pol2qm74	2443	4	,	,	,
cord-015021-pol2qm74	2443	5	there	there	EX
cord-015021-pol2qm74	2443	6	was	be	VBD
cord-015021-pol2qm74	2443	7	only	only	RB
cord-015021-pol2qm74	2443	8	a	a	DT
cord-015021-pol2qm74	2443	9	modest	modest	JJ
cord-015021-pol2qm74	2443	10	elevation	elevation	NN
cord-015021-pol2qm74	2443	11	of	of	IN
cord-015021-pol2qm74	2443	12	NOproduction	NOproduction	NNP
cord-015021-pol2qm74	2443	13	in	in	IN
cord-015021-pol2qm74	2443	14	rat	rat	NN
cord-015021-pol2qm74	2443	15	and	and	CC
cord-015021-pol2qm74	2443	16	mouse	mouse	NN
cord-015021-pol2qm74	2443	17	SC	SC	NNP
cord-015021-pol2qm74	2443	18	.	.	.
cord-015021-pol2qm74	2444	1	In	in	IN
cord-015021-pol2qm74	2444	2	first	first	JJ
cord-015021-pol2qm74	2444	3	experiments	experiment	NNS
cord-015021-pol2qm74	2444	4	we	-PRON-	PRP
cord-015021-pol2qm74	2444	5	could	could	MD
cord-015021-pol2qm74	2444	6	demonstrate	demonstrate	VB
cord-015021-pol2qm74	2444	7	NO	NO	NNP
cord-015021-pol2qm74	2444	8	-	-	HYPH
cord-015021-pol2qm74	2444	9	production	production	NN
cord-015021-pol2qm74	2444	10	also	also	RB
cord-015021-pol2qm74	2444	11	in	in	IN
cord-015021-pol2qm74	2444	12	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	2444	13	from	from	IN
cord-015021-pol2qm74	2444	14	a	a	DT
cord-015021-pol2qm74	2444	15	patient	patient	JJ
cord-015021-pol2qm74	2444	16	3	3	CD
cord-015021-pol2qm74	2444	17	days	day	NNS
cord-015021-pol2qm74	2444	18	aider	aider	NN
cord-015021-pol2qm74	2444	19	liver	liver	NN
cord-015021-pol2qm74	2444	20	partial	partial	JJ
cord-015021-pol2qm74	2444	21	resection	resection	NN
cord-015021-pol2qm74	2444	22	(	(	-LRB-
cord-015021-pol2qm74	2444	23	1.4	1.4	CD
cord-015021-pol2qm74	2444	24	nmol	nmol	JJ
cord-015021-pol2qm74	2444	25	nitrite/106	nitrite/106	NNP
cord-015021-pol2qm74	2444	26	cells	cell	NNS
cord-015021-pol2qm74	2444	27	)	)	-RRB-
cord-015021-pol2qm74	2445	1	Enhanced	enhanced	JJ
cord-015021-pol2qm74	2445	2	NO	no	JJ
cord-015021-pol2qm74	2445	3	-	-	HYPH
cord-015021-pol2qm74	2445	4	production	production	NN
cord-015021-pol2qm74	2445	5	in	in	IN
cord-015021-pol2qm74	2445	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	2445	7	may	may	MD
cord-015021-pol2qm74	2445	8	contribute	contribute	VB
cord-015021-pol2qm74	2445	9	to	to	IN
cord-015021-pol2qm74	2445	10	the	the	DT
cord-015021-pol2qm74	2445	11	changes	change	NNS
cord-015021-pol2qm74	2445	12	of	of	IN
cord-015021-pol2qm74	2445	13	immune	immune	JJ
cord-015021-pol2qm74	2445	14	reactivity	reactivity	NN
cord-015021-pol2qm74	2445	15	after	after	IN
cord-015021-pol2qm74	2445	16	partial	partial	JJ
cord-015021-pol2qm74	2445	17	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	2445	18	.	.	.
cord-015021-pol2qm74	2446	1	Nitric	nitric	NN
cord-015021-pol2qm74	2446	2	oxide	oxide	NN
cord-015021-pol2qm74	2446	3	(	(	-LRB-
cord-015021-pol2qm74	2446	4	NO	no	UH
cord-015021-pol2qm74	2446	5	)	)	-RRB-
cord-015021-pol2qm74	2446	6	is	be	VBZ
cord-015021-pol2qm74	2446	7	recognized	recognize	VBN
cord-015021-pol2qm74	2446	8	as	as	IN
cord-015021-pol2qm74	2446	9	an	an	DT
cord-015021-pol2qm74	2446	10	important	important	JJ
cord-015021-pol2qm74	2446	11	mediator	mediator	NN
cord-015021-pol2qm74	2446	12	in	in	IN
cord-015021-pol2qm74	2446	13	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2446	14	and	and	CC
cord-015021-pol2qm74	2446	15	sepsis	sepsis	NN
cord-015021-pol2qm74	2446	16	.	.	.
cord-015021-pol2qm74	2447	1	Increased	increase	VBN
cord-015021-pol2qm74	2447	2	synthesis	synthesis	NN
cord-015021-pol2qm74	2447	3	of	of	IN
cord-015021-pol2qm74	2447	4	NO	no	DT
cord-015021-pol2qm74	2447	5	has	have	VBZ
cord-015021-pol2qm74	2447	6	been	be	VBN
cord-015021-pol2qm74	2447	7	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2447	8	in	in	IN
cord-015021-pol2qm74	2447	9	septic	septic	JJ
cord-015021-pol2qm74	2447	10	humans	human	NNS
cord-015021-pol2qm74	2447	11	and	and	CC
cord-015021-pol2qm74	2447	12	animals	animal	NNS
cord-015021-pol2qm74	2447	13	,	,	,
cord-015021-pol2qm74	2447	14	and	and	CC
cord-015021-pol2qm74	2447	15	NO	no	DT
cord-015021-pol2qm74	2447	16	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	2447	17	have	have	VBP
cord-015021-pol2qm74	2447	18	been	be	VBN
cord-015021-pol2qm74	2447	19	used	use	VBN
cord-015021-pol2qm74	2447	20	in	in	IN
cord-015021-pol2qm74	2447	21	the	the	DT
cord-015021-pol2qm74	2447	22	treatment	treatment	NN
cord-015021-pol2qm74	2447	23	of	of	IN
cord-015021-pol2qm74	2447	24	septic	septic	JJ
cord-015021-pol2qm74	2447	25	shock	shock	NN
cord-015021-pol2qm74	2447	26	.	.	.
cord-015021-pol2qm74	2448	1	Recent	recent	JJ
cord-015021-pol2qm74	2448	2	reports	report	NNS
cord-015021-pol2qm74	2448	3	have	have	VBP
cord-015021-pol2qm74	2448	4	,	,	,
cord-015021-pol2qm74	2448	5	however	however	RB
cord-015021-pol2qm74	2448	6	,	,	,
cord-015021-pol2qm74	2448	7	suggested	suggest	VBD
cord-015021-pol2qm74	2448	8	that	that	IN
cord-015021-pol2qm74	2448	9	this	this	DT
cord-015021-pol2qm74	2448	10	form	form	NN
cord-015021-pol2qm74	2448	11	of	of	IN
cord-015021-pol2qm74	2448	12	therapy	therapy	NN
cord-015021-pol2qm74	2448	13	may	may	MD
cord-015021-pol2qm74	2448	14	cause	cause	VB
cord-015021-pol2qm74	2448	15	serious	serious	JJ
cord-015021-pol2qm74	2448	16	organ	organ	NN
cord-015021-pol2qm74	2448	17	damage	damage	NN
cord-015021-pol2qm74	2448	18	.	.	.
cord-015021-pol2qm74	2449	1	In	in	IN
cord-015021-pol2qm74	2449	2	the	the	DT
cord-015021-pol2qm74	2449	3	present	present	JJ
cord-015021-pol2qm74	2449	4	investigation	investigation	NN
cord-015021-pol2qm74	2449	5	circulatory	circulatory	JJ
cord-015021-pol2qm74	2449	6	and	and	CC
cord-015021-pol2qm74	2449	7	metabolic	metabolic	JJ
cord-015021-pol2qm74	2449	8	changes	change	NNS
cord-015021-pol2qm74	2449	9	in	in	IN
cord-015021-pol2qm74	2449	10	the	the	DT
cord-015021-pol2qm74	2449	11	liver	liver	NN
cord-015021-pol2qm74	2449	12	were	be	VBD
cord-015021-pol2qm74	2449	13	studied	study	VBN
cord-015021-pol2qm74	2449	14	during	during	IN
cord-015021-pol2qm74	2449	15	treatment	treatment	NN
cord-015021-pol2qm74	2449	16	with	with	IN
cord-015021-pol2qm74	2449	17	the	the	DT
cord-015021-pol2qm74	2449	18	NO	no	JJ
cord-015021-pol2qm74	2449	19	-	-	HYPH
cord-015021-pol2qm74	2449	20	synthase	synthase	NN
cord-015021-pol2qm74	2449	21	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2449	22	N	N	NNP
cord-015021-pol2qm74	2449	23	-	-	HYPH
cord-015021-pol2qm74	2449	24	nitro	nitro	NNP
cord-015021-pol2qm74	2449	25	-	-	HYPH
cord-015021-pol2qm74	2449	26	L	l	NN
cord-015021-pol2qm74	2449	27	-	-	HYPH
cord-015021-pol2qm74	2449	28	arginine	arginine	NN
cord-015021-pol2qm74	2449	29	-	-	HYPH
cord-015021-pol2qm74	2449	30	methyl	methyl	NN
cord-015021-pol2qm74	2449	31	ester	ester	NN
cord-015021-pol2qm74	2449	32	(	(	-LRB-
cord-015021-pol2qm74	2449	33	L	l	NN
cord-015021-pol2qm74	2449	34	-	-	HYPH
cord-015021-pol2qm74	2449	35	NAME	NAME	NNP
cord-015021-pol2qm74	2449	36	)	)	-RRB-
cord-015021-pol2qm74	2449	37	in	in	IN
cord-015021-pol2qm74	2449	38	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2449	39	.	.	.
cord-015021-pol2qm74	2450	1	Methods	method	NNS
cord-015021-pol2qm74	2450	2	:	:	:
cord-015021-pol2qm74	2450	3	Juvenile	juvenile	JJ
cord-015021-pol2qm74	2450	4	pigs	pig	NNS
cord-015021-pol2qm74	2450	5	were	be	VBD
cord-015021-pol2qm74	2450	6	randomized	randomize	VBN
cord-015021-pol2qm74	2450	7	to	to	IN
cord-015021-pol2qm74	2450	8	one	one	CD
cord-015021-pol2qm74	2450	9	of	of	IN
cord-015021-pol2qm74	2450	10	the	the	DT
cord-015021-pol2qm74	2450	11	following	following	JJ
cord-015021-pol2qm74	2450	12	treatment	treatment	NN
cord-015021-pol2qm74	2450	13	groups	group	NNS
cord-015021-pol2qm74	2450	14	:	:	:
cord-015021-pol2qm74	2450	15	1	1	LS
cord-015021-pol2qm74	2450	16	)	)	-RRB-
cord-015021-pol2qm74	2451	1	Encletoxin	Encletoxin	NNP
cord-015021-pol2qm74	2451	2	and	and	CC
cord-015021-pol2qm74	2451	3	L	L	NNP
cord-015021-pol2qm74	2451	4	-	-	HYPH
cord-015021-pol2qm74	2451	5	NAME	NAME	NNP
cord-015021-pol2qm74	2451	6	,	,	,
cord-015021-pol2qm74	2451	7	2	2	CD
cord-015021-pol2qm74	2451	8	)	)	-RRB-
cord-015021-pol2qm74	2451	9	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	2451	10	,	,	,
cord-015021-pol2qm74	2451	11	3	3	CD
cord-015021-pol2qm74	2451	12	)	)	-RRB-
cord-015021-pol2qm74	2451	13	NaCI	NaCI	NNP
cord-015021-pol2qm74	2451	14	and	and	CC
cord-015021-pol2qm74	2451	15	L	L	NNP
cord-015021-pol2qm74	2451	16	-	-	HYPH
cord-015021-pol2qm74	2451	17	NAME	NAME	NNP
cord-015021-pol2qm74	2451	18	,	,	,
cord-015021-pol2qm74	2451	19	4	4	CD
cord-015021-pol2qm74	2451	20	)	)	-RRB-
cord-015021-pol2qm74	2451	21	NaCh	nach	NN
cord-015021-pol2qm74	2451	22	Preliminary	preliminary	JJ
cord-015021-pol2qm74	2451	23	results	result	NNS
cord-015021-pol2qm74	2451	24	from	from	IN
cord-015021-pol2qm74	2451	25	groups	group	NNS
cord-015021-pol2qm74	2451	26	1	1	CD
cord-015021-pol2qm74	2451	27	(	(	-LRB-
cord-015021-pol2qm74	2451	28	n=7	n=7	NNS
cord-015021-pol2qm74	2451	29	)	)	-RRB-
cord-015021-pol2qm74	2451	30	and	and	CC
cord-015021-pol2qm74	2451	31	2	2	LS
cord-015021-pol2qm74	2451	32	(	(	-LRB-
cord-015021-pol2qm74	2451	33	n=8	n=8	NN
cord-015021-pol2qm74	2451	34	)	)	-RRB-
cord-015021-pol2qm74	2451	35	are	be	VBP
cord-015021-pol2qm74	2451	36	presented	present	VBN
cord-015021-pol2qm74	2451	37	.	.	.
cord-015021-pol2qm74	2452	1	Catheters	catheter	NNS
cord-015021-pol2qm74	2452	2	for	for	IN
cord-015021-pol2qm74	2452	3	pressure	pressure	NN
cord-015021-pol2qm74	2452	4	measurement	measurement	NN
cord-015021-pol2qm74	2452	5	were	be	VBD
cord-015021-pol2qm74	2452	6	introduced	introduce	VBN
cord-015021-pol2qm74	2452	7	into	into	IN
cord-015021-pol2qm74	2452	8	the	the	DT
cord-015021-pol2qm74	2452	9	aorta	aorta	NN
cord-015021-pol2qm74	2452	10	,	,	,
cord-015021-pol2qm74	2452	11	hepatic	hepatic	JJ
cord-015021-pol2qm74	2452	12	and	and	CC
cord-015021-pol2qm74	2452	13	portal	portal	JJ
cord-015021-pol2qm74	2452	14	veins	vein	NNS
cord-015021-pol2qm74	2452	15	and	and	CC
cord-015021-pol2qm74	2452	16	ultrasonic	ultrasonic	JJ
cord-015021-pol2qm74	2452	17	transit	transit	NN
cord-015021-pol2qm74	2452	18	time	time	NN
cord-015021-pol2qm74	2452	19	flow	flow	NN
cord-015021-pol2qm74	2452	20	probes	probe	NNS
cord-015021-pol2qm74	2452	21	were	be	VBD
cord-015021-pol2qm74	2452	22	placed	place	VBN
cord-015021-pol2qm74	2452	23	on	on	IN
cord-015021-pol2qm74	2452	24	the	the	DT
cord-015021-pol2qm74	2452	25	hepatic	hepatic	JJ
cord-015021-pol2qm74	2452	26	artery	artery	NN
cord-015021-pol2qm74	2452	27	and	and	CC
cord-015021-pol2qm74	2452	28	portal	portal	JJ
cord-015021-pol2qm74	2452	29	vein	vein	NN
cord-015021-pol2qm74	2452	30	.	.	.
cord-015021-pol2qm74	2453	1	A	a	DT
cord-015021-pol2qm74	2453	2	catheter	catheter	NN
cord-015021-pol2qm74	2453	3	was	be	VBD
cord-015021-pol2qm74	2453	4	introduced	introduce	VBN
cord-015021-pol2qm74	2453	5	into	into	IN
cord-015021-pol2qm74	2453	6	the	the	DT
cord-015021-pol2qm74	2453	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2453	8	artery	artery	NN
cord-015021-pol2qm74	2453	9	.	.	.
cord-015021-pol2qm74	2454	1	Endotoxin	Endotoxin	NNP
cord-015021-pol2qm74	2454	2	(	(	-LRB-
cord-015021-pol2qm74	2454	3	1.7	1.7	CD
cord-015021-pol2qm74	2454	4	gg	gg	NNP
cord-015021-pol2qm74	2454	5	/	/	SYM
cord-015021-pol2qm74	2454	6	kg	kg	NNP
cord-015021-pol2qm74	2454	7	/	/	SYM
cord-015021-pol2qm74	2454	8	h	h	NN
cord-015021-pol2qm74	2454	9	)	)	-RRB-
cord-015021-pol2qm74	2454	10	was	be	VBD
cord-015021-pol2qm74	2454	11	given	give	VBN
cord-015021-pol2qm74	2454	12	as	as	IN
cord-015021-pol2qm74	2454	13	a	a	DT
cord-015021-pol2qm74	2454	14	continous	continous	JJ
cord-015021-pol2qm74	2454	15	portal	portal	JJ
cord-015021-pol2qm74	2454	16	infusion	infusion	NN
cord-015021-pol2qm74	2454	17	over	over	IN
cord-015021-pol2qm74	2454	18	the	the	DT
cord-015021-pol2qm74	2454	19	entire	entire	JJ
cord-015021-pol2qm74	2454	20	observation	observation	NN
cord-015021-pol2qm74	2454	21	period	period	NN
cord-015021-pol2qm74	2454	22	of	of	IN
cord-015021-pol2qm74	2454	23	8	8	CD
cord-015021-pol2qm74	2454	24	hrs	hrs	NN
cord-015021-pol2qm74	2454	25	.	.	.
cord-015021-pol2qm74	2455	1	L	l	NN
cord-015021-pol2qm74	2455	2	-	-	HYPH
cord-015021-pol2qm74	2455	3	NAME	NAME	NNP
cord-015021-pol2qm74	2455	4	(	(	-LRB-
cord-015021-pol2qm74	2455	5	25	25	CD
cord-015021-pol2qm74	2455	6	mg	mg	NNP
cord-015021-pol2qm74	2455	7	/	/	SYM
cord-015021-pol2qm74	2455	8	kg	kg	NNP
cord-015021-pol2qm74	2455	9	)	)	-RRB-
cord-015021-pol2qm74	2455	10	was	be	VBD
cord-015021-pol2qm74	2455	11	given	give	VBN
cord-015021-pol2qm74	2455	12	as	as	IN
cord-015021-pol2qm74	2455	13	a	a	DT
cord-015021-pol2qm74	2455	14	bolus	bolus	NN
cord-015021-pol2qm74	2455	15	after	after	IN
cord-015021-pol2qm74	2455	16	3	3	CD
cord-015021-pol2qm74	2455	17	hrs	hrs	NN
cord-015021-pol2qm74	2455	18	.	.	.
cord-015021-pol2qm74	2456	1	of	of	IN
cord-015021-pol2qm74	2456	2	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2456	3	.	.	.
cord-015021-pol2qm74	2457	1	Results	result	NNS
cord-015021-pol2qm74	2457	2	:	:	:
cord-015021-pol2qm74	2458	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	2458	2	transiently	transiently	RB
cord-015021-pol2qm74	2458	3	reduced	reduce	VBD
cord-015021-pol2qm74	2458	4	portal	portal	JJ
cord-015021-pol2qm74	2458	5	vein	vein	NN
cord-015021-pol2qm74	2458	6	flow	flow	NN
cord-015021-pol2qm74	2458	7	(	(	-LRB-
cord-015021-pol2qm74	2458	8	PVF	PVF	NNP
cord-015021-pol2qm74	2458	9	)	)	-RRB-
cord-015021-pol2qm74	2458	10	by	by	IN
cord-015021-pol2qm74	2458	11	25	25	CD
cord-015021-pol2qm74	2458	12	%	%	NN
cord-015021-pol2qm74	2458	13	*	*	NFP
cord-015021-pol2qm74	2458	14	and	and	CC
cord-015021-pol2qm74	2458	15	hepatic	hepatic	JJ
cord-015021-pol2qm74	2458	16	artery	artery	NN
cord-015021-pol2qm74	2458	17	flow	flow	NN
cord-015021-pol2qm74	2458	18	(	(	-LRB-
cord-015021-pol2qm74	2458	19	HAl	hal	JJ
cord-015021-pol2qm74	2458	20	e	e	NN
cord-015021-pol2qm74	2458	21	)	)	-RRB-
cord-015021-pol2qm74	2458	22	by	by	IN
cord-015021-pol2qm74	2458	23	45	45	CD
cord-015021-pol2qm74	2458	24	%	%	NN
cord-015021-pol2qm74	2459	1	*	*	NFP
cord-015021-pol2qm74	2459	2	,	,	,
cord-015021-pol2qm74	2459	3	while	while	IN
cord-015021-pol2qm74	2459	4	L	l	NN
cord-015021-pol2qm74	2459	5	-	-	HYPH
cord-015021-pol2qm74	2459	6	NAME	NAME	NNP
cord-015021-pol2qm74	2459	7	caused	cause	VBD
cord-015021-pol2qm74	2459	8	a	a	DT
cord-015021-pol2qm74	2459	9	further	further	JJ
cord-015021-pol2qm74	2459	10	and	and	CC
cord-015021-pol2qm74	2459	11	lasting	lasting	JJ
cord-015021-pol2qm74	2459	12	reduction	reduction	NN
cord-015021-pol2qm74	2459	13	in	in	IN
cord-015021-pol2qm74	2459	14	flow	flow	NN
cord-015021-pol2qm74	2459	15	(	(	-LRB-
cord-015021-pol2qm74	2459	16	PVF	PVF	NNP
cord-015021-pol2qm74	2459	17	78	78	CD
cord-015021-pol2qm74	2459	18	%	%	NN
cord-015021-pol2qm74	2459	19	,	,	,
cord-015021-pol2qm74	2459	20	HAF	HAF	NNP
cord-015021-pol2qm74	2459	21	90	90	CD
cord-015021-pol2qm74	2459	22	%	%	NN
cord-015021-pol2qm74	2459	23	)	)	-RRB-
cord-015021-pol2qm74	2460	1	*	*	NFP
cord-015021-pol2qm74	2460	2	.	.	.
cord-015021-pol2qm74	2461	1	Transhepatic	Transhepatic	NNP
cord-015021-pol2qm74	2461	2	(	(	-LRB-
cord-015021-pol2qm74	2461	3	portal	portal	JJ
cord-015021-pol2qm74	2461	4	-	-	HYPH
cord-015021-pol2qm74	2461	5	hepatic	hepatic	JJ
cord-015021-pol2qm74	2461	6	vein	vein	NN
cord-015021-pol2qm74	2461	7	)	)	-RRB-
cord-015021-pol2qm74	2462	1	vascular	vascular	JJ
cord-015021-pol2qm74	2462	2	resistance	resistance	NN
cord-015021-pol2qm74	2462	3	increased	increase	VBD
cord-015021-pol2qm74	2462	4	to	to	IN
cord-015021-pol2qm74	2462	5	3	3	CD
cord-015021-pol2qm74	2462	6	times	time	NNS
cord-015021-pol2qm74	2462	7	baseline	baseline	JJ
cord-015021-pol2qm74	2462	8	value	value	NN
cord-015021-pol2qm74	2462	9	during	during	IN
cord-015021-pol2qm74	2462	10	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2462	11	while	while	IN
cord-015021-pol2qm74	2462	12	L	l	NN
cord-015021-pol2qm74	2462	13	-	-	HYPH
cord-015021-pol2qm74	2462	14	NAME	NAME	NNP
cord-015021-pol2qm74	2462	15	caused	cause	VBD
cord-015021-pol2qm74	2462	16	a	a	DT
cord-015021-pol2qm74	2462	17	further	further	RB
cord-015021-pol2qm74	2462	18	marked	mark	VBN
cord-015021-pol2qm74	2462	19	increase	increase	NN
cord-015021-pol2qm74	2462	20	in	in	IN
cord-015021-pol2qm74	2462	21	resistance	resistance	NN
cord-015021-pol2qm74	2462	22	to	to	IN
cord-015021-pol2qm74	2462	23	12	12	CD
cord-015021-pol2qm74	2462	24	times	time	NNS
cord-015021-pol2qm74	2462	25	initial	initial	JJ
cord-015021-pol2qm74	2462	26	value	value	NN
cord-015021-pol2qm74	2462	27	.	.	.
cord-015021-pol2qm74	2463	1	Portal	portal	JJ
cord-015021-pol2qm74	2463	2	oxygen	oxygen	NN
cord-015021-pol2qm74	2463	3	saturation	saturation	NN
cord-015021-pol2qm74	2463	4	(	(	-LRB-
cord-015021-pol2qm74	2463	5	SO2	SO2	NNP
cord-015021-pol2qm74	2463	6	)	)	-RRB-
cord-015021-pol2qm74	2463	7	decreased	decrease	VBD
cord-015021-pol2qm74	2463	8	by	by	IN
cord-015021-pol2qm74	2463	9	60	60	CD
cord-015021-pol2qm74	2463	10	%	%	NN
cord-015021-pol2qm74	2463	11	*	*	NFP
cord-015021-pol2qm74	2463	12	during	during	IN
cord-015021-pol2qm74	2463	13	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2463	14	.	.	.
cord-015021-pol2qm74	2464	1	L	l	NN
cord-015021-pol2qm74	2464	2	-	-	HYPH
cord-015021-pol2qm74	2464	3	NAME	name	NN
cord-015021-pol2qm74	2464	4	caused	cause	VBD
cord-015021-pol2qm74	2464	5	a	a	DT
cord-015021-pol2qm74	2464	6	reduction	reduction	NN
cord-015021-pol2qm74	2464	7	in	in	IN
cord-015021-pol2qm74	2464	8	portal	portal	JJ
cord-015021-pol2qm74	2464	9	SO2	SO2	NNP
cord-015021-pol2qm74	2464	10	by	by	IN
cord-015021-pol2qm74	2464	11	87	87	CD
cord-015021-pol2qm74	2464	12	%	%	NN
cord-015021-pol2qm74	2465	1	*	*	NFP
cord-015021-pol2qm74	2465	2	.	.	.
cord-015021-pol2qm74	2466	1	Arterial	arterial	JJ
cord-015021-pol2qm74	2466	2	SO2	SO2	NNP
cord-015021-pol2qm74	2466	3	was	be	VBD
cord-015021-pol2qm74	2466	4	unchanged	unchanged	JJ
cord-015021-pol2qm74	2466	5	in	in	IN
cord-015021-pol2qm74	2466	6	both	both	DT
cord-015021-pol2qm74	2466	7	groups	group	NNS
cord-015021-pol2qm74	2466	8	.	.	.
cord-015021-pol2qm74	2467	1	Hepatic	hepatic	JJ
cord-015021-pol2qm74	2467	2	oxygen	oxygen	NN
cord-015021-pol2qm74	2467	3	uptake	uptake	NN
cord-015021-pol2qm74	2467	4	was	be	VBD
cord-015021-pol2qm74	2467	5	not	not	RB
cord-015021-pol2qm74	2467	6	changed	change	VBN
cord-015021-pol2qm74	2467	7	by	by	IN
cord-015021-pol2qm74	2467	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2467	9	,	,	,
cord-015021-pol2qm74	2467	10	but	but	CC
cord-015021-pol2qm74	2467	11	was	be	VBD
cord-015021-pol2qm74	2467	12	markedly	markedly	RB
cord-015021-pol2qm74	2467	13	reduced	reduce	VBN
cord-015021-pol2qm74	2467	14	after	after	IN
cord-015021-pol2qm74	2467	15	addition	addition	NN
cord-015021-pol2qm74	2467	16	of	of	IN
cord-015021-pol2qm74	2467	17	L	l	NN
cord-015021-pol2qm74	2467	18	-	-	HYPH
cord-015021-pol2qm74	2467	19	NAME	NAME	NNP
cord-015021-pol2qm74	2467	20	.	.	.
cord-015021-pol2qm74	2468	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	2468	2	caused	cause	VBD
cord-015021-pol2qm74	2468	3	a	a	DT
cord-015021-pol2qm74	2468	4	27	27	CD
cord-015021-pol2qm74	2468	5	%	%	NN
cord-015021-pol2qm74	2468	6	reduction	reduction	NN
cord-015021-pol2qm74	2468	7	in	in	IN
cord-015021-pol2qm74	2468	8	cardiac	cardiac	JJ
cord-015021-pol2qm74	2468	9	output	output	NN
cord-015021-pol2qm74	2468	10	(	(	-LRB-
cord-015021-pol2qm74	2468	11	CO	CO	NNP
cord-015021-pol2qm74	2468	12	)	)	-RRB-
cord-015021-pol2qm74	2468	13	.	.	.
cord-015021-pol2qm74	2469	1	The	the	DT
cord-015021-pol2qm74	2469	2	addition	addition	NN
cord-015021-pol2qm74	2469	3	of	of	IN
cord-015021-pol2qm74	2469	4	L	l	NN
cord-015021-pol2qm74	2469	5	-	-	HYPH
cord-015021-pol2qm74	2469	6	NAME	NAME	NNP
cord-015021-pol2qm74	2469	7	reduced	reduce	VBN
cord-015021-pol2qm74	2469	8	CO	CO	NNP
cord-015021-pol2qm74	2469	9	by	by	IN
cord-015021-pol2qm74	2469	10	a	a	DT
cord-015021-pol2qm74	2469	11	total	total	NN
cord-015021-pol2qm74	2469	12	of	of	IN
cord-015021-pol2qm74	2469	13	71	71	CD
cord-015021-pol2qm74	2469	14	%	%	NN
cord-015021-pol2qm74	2469	15	*	*	NFP
cord-015021-pol2qm74	2469	16	.	.	.
cord-015021-pol2qm74	2470	1	*	*	NFP
cord-015021-pol2qm74	2470	2	:	:	:
cord-015021-pol2qm74	2470	3	p	p	NN
cord-015021-pol2qm74	2470	4	<	<	XX
cord-015021-pol2qm74	2470	5	0.05	0.05	CD
cord-015021-pol2qm74	2470	6	.	.	.
cord-015021-pol2qm74	2471	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	2471	2	:	:	:
cord-015021-pol2qm74	2471	3	Is	be	VBZ
cord-015021-pol2qm74	2471	4	the	the	DT
cord-015021-pol2qm74	2471	5	present	present	JJ
cord-015021-pol2qm74	2471	6	model	model	NN
cord-015021-pol2qm74	2471	7	of	of	IN
cord-015021-pol2qm74	2471	8	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2471	9	treatment	treatment	NN
cord-015021-pol2qm74	2471	10	with	with	IN
cord-015021-pol2qm74	2471	11	the	the	DT
cord-015021-pol2qm74	2471	12	nitric	nitric	NN
cord-015021-pol2qm74	2471	13	oxide	oxide	NN
cord-015021-pol2qm74	2471	14	synthase	synthase	NN
cord-015021-pol2qm74	2471	15	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2471	16	L	l	NN
cord-015021-pol2qm74	2471	17	-	-	HYPH
cord-015021-pol2qm74	2471	18	NAME	name	NN
cord-015021-pol2qm74	2471	19	markedly	markedly	RB
cord-015021-pol2qm74	2471	20	reduced	reduce	VBD
cord-015021-pol2qm74	2471	21	liver	liver	NN
cord-015021-pol2qm74	2471	22	perfusion	perfusion	NN
cord-015021-pol2qm74	2471	23	and	and	CC
cord-015021-pol2qm74	2471	24	portal	portal	JJ
cord-015021-pol2qm74	2471	25	oxygen	oxygen	NN
cord-015021-pol2qm74	2471	26	supply	supply	NN
cord-015021-pol2qm74	2471	27	.	.	.
cord-015021-pol2qm74	2472	1	This	this	DT
cord-015021-pol2qm74	2472	2	might	may	MD
cord-015021-pol2qm74	2472	3	explain	explain	VB
cord-015021-pol2qm74	2472	4	the	the	DT
cord-015021-pol2qm74	2472	5	increased	increase	VBN
cord-015021-pol2qm74	2472	6	liver	liver	NN
cord-015021-pol2qm74	2472	7	damage	damage	NN
cord-015021-pol2qm74	2472	8	reported	report	VBN
cord-015021-pol2qm74	2472	9	in	in	IN
cord-015021-pol2qm74	2472	10	previous	previous	JJ
cord-015021-pol2qm74	2472	11	studies	study	NNS
cord-015021-pol2qm74	2472	12	using	use	VBG
cord-015021-pol2qm74	2472	13	NO	NO	NNP
cord-015021-pol2qm74	2472	14	-	-	HYPH
cord-015021-pol2qm74	2472	15	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	2472	16	.	.	.
cord-015021-pol2qm74	2473	1	The	the	DT
cord-015021-pol2qm74	2473	2	increase	increase	NN
cord-015021-pol2qm74	2473	3	in	in	IN
cord-015021-pol2qm74	2473	4	transhepatic	transhepatic	JJ
cord-015021-pol2qm74	2473	5	resistance	resistance	NN
cord-015021-pol2qm74	2473	6	found	find	VBN
cord-015021-pol2qm74	2473	7	after	after	IN
cord-015021-pol2qm74	2473	8	L	l	NN
cord-015021-pol2qm74	2473	9	-	-	HYPH
cord-015021-pol2qm74	2473	10	NAME	name	NN
cord-015021-pol2qm74	2473	11	treatment	treatment	NN
cord-015021-pol2qm74	2473	12	will	will	MD
cord-015021-pol2qm74	2473	13	tend	tend	VB
cord-015021-pol2qm74	2473	14	to	to	TO
cord-015021-pol2qm74	2473	15	cause	cause	VB
cord-015021-pol2qm74	2473	16	pooling	pooling	NN
cord-015021-pol2qm74	2473	17	of	of	IN
cord-015021-pol2qm74	2473	18	blood	blood	NN
cord-015021-pol2qm74	2473	19	in	in	IN
cord-015021-pol2qm74	2473	20	the	the	DT
cord-015021-pol2qm74	2473	21	splanchnic	splanchnic	JJ
cord-015021-pol2qm74	2473	22	veins	vein	NNS
cord-015021-pol2qm74	2473	23	,	,	,
cord-015021-pol2qm74	2473	24	resulting	result	VBG
cord-015021-pol2qm74	2473	25	in	in	IN
cord-015021-pol2qm74	2473	26	reduced	reduce	VBN
cord-015021-pol2qm74	2473	27	filling	filling	NN
cord-015021-pol2qm74	2473	28	of	of	IN
cord-015021-pol2qm74	2473	29	the	the	DT
cord-015021-pol2qm74	2473	30	heart	heart	NN
cord-015021-pol2qm74	2473	31	and	and	CC
cord-015021-pol2qm74	2473	32	thus	thus	RB
cord-015021-pol2qm74	2473	33	contribute	contribute	VB
cord-015021-pol2qm74	2473	34	to	to	IN
cord-015021-pol2qm74	2473	35	the	the	DT
cord-015021-pol2qm74	2473	36	observed	observed	JJ
cord-015021-pol2qm74	2473	37	reduction	reduction	NN
cord-015021-pol2qm74	2473	38	in	in	IN
cord-015021-pol2qm74	2473	39	cardiac	cardiac	JJ
cord-015021-pol2qm74	2473	40	output	output	NN
cord-015021-pol2qm74	2473	41	.	.	.
cord-015021-pol2qm74	2474	1	Institute	Institute	NNP
cord-015021-pol2qm74	2474	2	for	for	IN
cord-015021-pol2qm74	2474	3	Surgical	Surgical	NNP
cord-015021-pol2qm74	2474	4	Research	Research	NNP
cord-015021-pol2qm74	2474	5	,	,	,
cord-015021-pol2qm74	2474	6	Rikshospitalet	Rikshospitalet	NNP
cord-015021-pol2qm74	2474	7	,	,	,
cord-015021-pol2qm74	2474	8	The	the	DT
cord-015021-pol2qm74	2474	9	National	National	NNP
cord-015021-pol2qm74	2474	10	Hospital	Hospital	NNP
cord-015021-pol2qm74	2474	11	,	,	,
cord-015021-pol2qm74	2474	12	University	University	NNP
cord-015021-pol2qm74	2474	13	of	of	IN
cord-015021-pol2qm74	2474	14	Oslo	Oslo	NNP
cord-015021-pol2qm74	2474	15	,	,	,
cord-015021-pol2qm74	2474	16	0027	0027	CD
cord-015021-pol2qm74	2474	17	Oslo	Oslo	NNP
cord-015021-pol2qm74	2474	18	,	,	,
cord-015021-pol2qm74	2474	19	Norway	Norway	NNP
cord-015021-pol2qm74	2474	20	.	.	.
cord-015021-pol2qm74	2475	1	We	-PRON-	PRP
cord-015021-pol2qm74	2475	2	have	have	VBP
cord-015021-pol2qm74	2475	3	investigated	investigate	VBN
cord-015021-pol2qm74	2475	4	the	the	DT
cord-015021-pol2qm74	2475	5	role	role	NN
cord-015021-pol2qm74	2475	6	of	of	IN
cord-015021-pol2qm74	2475	7	tumour	tumour	NN
cord-015021-pol2qm74	2475	8	necrosis	necrosis	NN
cord-015021-pol2qm74	2475	9	factor	factor	NN
cord-015021-pol2qm74	2475	10	(	(	-LRB-
cord-015021-pol2qm74	2475	11	TNF	TNF	NNP
cord-015021-pol2qm74	2475	12	)	)	-RRB-
cord-015021-pol2qm74	2475	13	and	and	CC
cord-015021-pol2qm74	2475	14	interleukin	interleukin	NN
cord-015021-pol2qm74	2475	15	-	-	:
cord-015021-pol2qm74	2475	16	i	i	JJ
cord-015021-pol2qm74	2475	17	(	(	-LRB-
cord-015021-pol2qm74	2475	18	IL	IL	NNP
cord-015021-pol2qm74	2475	19	-	-	:
cord-015021-pol2qm74	2475	20	I	I	NNP
cord-015021-pol2qm74	2475	21	)	)	-RRB-
cord-015021-pol2qm74	2475	22	in	in	IN
cord-015021-pol2qm74	2475	23	the	the	DT
cord-015021-pol2qm74	2475	24	induction	induction	NN
cord-015021-pol2qm74	2475	25	of	of	IN
cord-015021-pol2qm74	2475	26	nitric	nitric	JJ
cord-015021-pol2qm74	2475	27	oxide	oxide	NN
cord-015021-pol2qm74	2475	28	synthase	synthase	NN
cord-015021-pol2qm74	2475	29	(	(	-LRB-
cord-015021-pol2qm74	2475	30	NOS	NOS	NNP
cord-015021-pol2qm74	2475	31	)	)	-RRB-
cord-015021-pol2qm74	2475	32	by	by	IN
cord-015021-pol2qm74	2475	33	bacterial	bacterial	JJ
cord-015021-pol2qm74	2475	34	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2476	1	(	(	-LRB-
cord-015021-pol2qm74	2476	2	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	2476	3	;	;	:
cord-015021-pol2qm74	2476	4	LPS	lp	NNS
cord-015021-pol2qm74	2476	5	;	;	:
cord-015021-pol2qm74	2476	6	2	2	CD
cord-015021-pol2qm74	2476	7	mg	mg	NNP
cord-015021-pol2qm74	2476	8	kg	kg	NNP
cord-015021-pol2qm74	2476	9	-I	-I	NNP
cord-015021-pol2qm74	2476	10	i.v	i.v	NNP
cord-015021-pol2qm74	2476	11	.	.	.
cord-015021-pol2qm74	2476	12	)	)	-RRB-
cord-015021-pol2qm74	2477	1	in	in	IN
cord-015021-pol2qm74	2477	2	vivo	vivo	NNP
cord-015021-pol2qm74	2477	3	.	.	.
cord-015021-pol2qm74	2478	1	In	in	IN
cord-015021-pol2qm74	2478	2	anaesthetized	anaesthetized	JJ
cord-015021-pol2qm74	2478	3	rats	rat	NNS
cord-015021-pol2qm74	2478	4	,	,	,
cord-015021-pol2qm74	2478	5	pretreatment	pretreatment	NN
cord-015021-pol2qm74	2478	6	with	with	IN
cord-015021-pol2qm74	2478	7	a	a	DT
cord-015021-pol2qm74	2478	8	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	2478	9	antibody	antibody	NN
cord-015021-pol2qm74	2478	10	for	for	IN
cord-015021-pol2qm74	2478	11	TNF	TNF	NNP
cord-015021-pol2qm74	2479	1	(	(	-LRB-
cord-015021-pol2qm74	2479	2	TNFab	tnfab	RB
cord-015021-pol2qm74	2479	3	;	;	:
cord-015021-pol2qm74	2479	4	20	20	CD
cord-015021-pol2qm74	2479	5	mg	mg	NN
cord-015021-pol2qm74	2479	6	kg	kg	NNP
cord-015021-pol2qm74	2479	7	-I	-I	NNP
cord-015021-pol2qm74	2479	8	s.c	s.c	NNP
cord-015021-pol2qm74	2479	9	.	.	NNP
cord-015021-pol2qm74	2479	10	,	,	,
cord-015021-pol2qm74	2479	11	at	at	IN
cord-015021-pol2qm74	2479	12	16	16	CD
cord-015021-pol2qm74	2479	13	h	h	NN
cord-015021-pol2qm74	2479	14	prior	prior	RB
cord-015021-pol2qm74	2479	15	to	to	IN
cord-015021-pol2qm74	2479	16	LPS	LPS	NNP
cord-015021-pol2qm74	2479	17	)	)	-RRB-
cord-015021-pol2qm74	2479	18	or	or	CC
cord-015021-pol2qm74	2479	19	with	with	IN
cord-015021-pol2qm74	2479	20	an	an	DT
cord-015021-pol2qm74	2479	21	IL	IL	NNP
cord-015021-pol2qm74	2479	22	-	-	HYPH
cord-015021-pol2qm74	2479	23	I	i	NN
cord-015021-pol2qm74	2479	24	receptor	receptor	NN
cord-015021-pol2qm74	2479	25	antagonist	antagonist	NN
cord-015021-pol2qm74	2479	26	(	(	-LRB-
cord-015021-pol2qm74	2479	27	IL	IL	NNP
cord-015021-pol2qm74	2479	28	-	-	HYPH
cord-015021-pol2qm74	2479	29	Ira	Ira	NNP
cord-015021-pol2qm74	2479	30	;	;	:
cord-015021-pol2qm74	2479	31	16	16	CD
cord-015021-pol2qm74	2479	32	mg	mg	NNP
cord-015021-pol2qm74	2479	33	/	/	SYM
cord-015021-pol2qm74	2479	34	kg	kg	NN
cord-015021-pol2qm74	2479	35	bolus	bolus	NN
cord-015021-pol2qm74	2479	36	and	and	CC
cord-015021-pol2qm74	2479	37	2.4	2.4	CD
cord-015021-pol2qm74	2479	38	mg	mg	NNP
cord-015021-pol2qm74	2479	39	/	/	SYM
cord-015021-pol2qm74	2479	40	kg	kg	NNP
cord-015021-pol2qm74	2479	41	/	/	SYM
cord-015021-pol2qm74	2479	42	h	h	NN
cord-015021-pol2qm74	2479	43	infusion	infusion	NN
cord-015021-pol2qm74	2479	44	)	)	-RRB-
cord-015021-pol2qm74	2479	45	ameliorated	ameliorate	VBD
cord-015021-pol2qm74	2479	46	the	the	DT
cord-015021-pol2qm74	2479	47	fall	fall	NN
cord-015021-pol2qm74	2479	48	in	in	IN
cord-015021-pol2qm74	2479	49	mean	mean	JJ
cord-015021-pol2qm74	2479	50	arterial	arterial	JJ
cord-015021-pol2qm74	2479	51	blood	blood	NN
cord-015021-pol2qm74	2479	52	pressure	pressure	NN
cord-015021-pol2qm74	2479	53	(	(	-LRB-
cord-015021-pol2qm74	2479	54	MAP	MAP	NNP
cord-015021-pol2qm74	2479	55	)	)	-RRB-
cord-015021-pol2qm74	2479	56	at	at	IN
cord-015021-pol2qm74	2479	57	90	90	CD
cord-015021-pol2qm74	2479	58	-	-	SYM
cord-015021-pol2qm74	2479	59	180	180	CD
cord-015021-pol2qm74	2479	60	min	min	NN
cord-015021-pol2qm74	2479	61	after	after	IN
cord-015021-pol2qm74	2479	62	LPS	lp	NNS
cord-015021-pol2qm74	2479	63	.	.	.
cord-015021-pol2qm74	2480	1	For	for	IN
cord-015021-pol2qm74	2480	2	instance	instance	NN
cord-015021-pol2qm74	2480	3	,	,	,
cord-015021-pol2qm74	2480	4	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	2480	5	for	for	IN
cord-015021-pol2qm74	2480	6	180	180	CD
cord-015021-pol2qm74	2480	7	min	min	NN
cord-015021-pol2qm74	2480	8	resulted	result	VBD
cord-015021-pol2qm74	2480	9	in	in	IN
cord-015021-pol2qm74	2480	10	a	a	DT
cord-015021-pol2qm74	2480	11	fall	fall	NN
cord-015021-pol2qm74	2480	12	in	in	IN
cord-015021-pol2qm74	2480	13	MAP	MAP	NNP
cord-015021-pol2qm74	2480	14	from	from	IN
cord-015021-pol2qm74	2480	15	114-+6	114-+6	CD
cord-015021-pol2qm74	2480	16	(	(	-LRB-
cord-015021-pol2qm74	2480	17	control	control	NN
cord-015021-pol2qm74	2480	18	)	)	-RRB-
cord-015021-pol2qm74	2480	19	to	to	IN
cord-015021-pol2qm74	2480	20	79-+4	79-+4	CD
cord-015021-pol2qm74	2480	21	mmHg	mmHg	NNS
cord-015021-pol2qm74	2480	22	(	(	-LRB-
cord-015021-pol2qm74	2480	23	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	2480	24	;	;	,
cord-015021-pol2qm74	2480	25	n=8	n=8	NN
cord-015021-pol2qm74	2480	26	)	)	-RRB-
cord-015021-pol2qm74	2480	27	.	.	.
cord-015021-pol2qm74	2481	1	In	in	IN
cord-015021-pol2qm74	2481	2	contrast	contrast	NN
cord-015021-pol2qm74	2481	3	,	,	,
cord-015021-pol2qm74	2481	4	animals	animal	NNS
cord-015021-pol2qm74	2481	5	pretreated	pretreate	VBN
cord-015021-pol2qm74	2481	6	with	with	IN
cord-015021-pol2qm74	2481	7	TNFab	TNFab	NNP
cord-015021-pol2qm74	2481	8	or	or	CC
cord-015021-pol2qm74	2481	9	IL	IL	NNP
cord-015021-pol2qm74	2481	10	-	-	HYPH
cord-015021-pol2qm74	2481	11	ira	ira	NNP
cord-015021-pol2qm74	2481	12	prior	prior	RB
cord-015021-pol2qm74	2481	13	to	to	IN
cord-015021-pol2qm74	2481	14	LPS	LPS	NNP
cord-015021-pol2qm74	2481	15	injection	injection	NN
cord-015021-pol2qm74	2481	16	maintained	maintain	VBD
cord-015021-pol2qm74	2481	17	significantly	significantly	RB
cord-015021-pol2qm74	2481	18	higher	high	JJR
cord-015021-pol2qm74	2481	19	MAP	map	NN
cord-015021-pol2qm74	2481	20	at	at	IN
cord-015021-pol2qm74	2481	21	180	180	CD
cord-015021-pol2qm74	2481	22	min	min	NN
cord-015021-pol2qm74	2481	23	when	when	WRB
cord-015021-pol2qm74	2481	24	compared	compare	VBN
cord-015021-pol2qm74	2481	25	to	to	IN
cord-015021-pol2qm74	2481	26	LPS	LPS	NNP
cord-015021-pol2qm74	2481	27	-	-	HYPH
cord-015021-pol2qm74	2481	28	control	control	NN
cord-015021-pol2qm74	2481	29	:	:	:
cord-015021-pol2qm74	2481	30	118-+3	118-+3	LS
cord-015021-pol2qm74	2481	31	mmEg	mmEg	NNS
cord-015021-pol2qm74	2481	32	(	(	-LRB-
cord-015021-pol2qm74	2481	33	n=5	n=5	NNP
cord-015021-pol2qm74	2481	34	)	)	-RRB-
cord-015021-pol2qm74	2481	35	and	and	CC
cord-015021-pol2qm74	2481	36	103-+7	103-+7	CD
cord-015021-pol2qm74	2481	37	mmHg	mmHg	NNS
cord-015021-pol2qm74	2481	38	(	(	-LRB-
cord-015021-pol2qm74	2481	39	n=5	n=5	NNP
cord-015021-pol2qm74	2481	40	)	)	-RRB-
cord-015021-pol2qm74	2481	41	,	,	,
cord-015021-pol2qm74	2481	42	respectively	respectively	RB
cord-015021-pol2qm74	2481	43	(	(	-LRB-
cord-015021-pol2qm74	2481	44	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	2481	45	)	)	-RRB-
cord-015021-pol2qm74	2481	46	.	.	.
cord-015021-pol2qm74	2482	1	Three	three	CD
cord-015021-pol2qm74	2482	2	hours	hour	NNS
cord-015021-pol2qm74	2482	3	of	of	IN
cord-015021-pol2qm74	2482	4	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	2482	5	significantly	significantly	RB
cord-015021-pol2qm74	2482	6	reduced	reduce	VBD
cord-015021-pol2qm74	2482	7	the	the	DT
cord-015021-pol2qm74	2482	8	contractile	contractile	JJ
cord-015021-pol2qm74	2482	9	effects	effect	NNS
cord-015021-pol2qm74	2482	10	of	of	IN
cord-015021-pol2qm74	2482	11	noradrenaline	noradrenaline	NN
cord-015021-pol2qm74	2482	12	(	(	-LRB-
cord-015021-pol2qm74	2482	13	NA	NA	NNP
cord-015021-pol2qm74	2482	14	)	)	-RRB-
cord-015021-pol2qm74	2482	15	in	in	IN
cord-015021-pol2qm74	2482	16	the	the	DT
cord-015021-pol2qm74	2482	17	thoracic	thoracic	JJ
cord-015021-pol2qm74	2482	18	aorta	aorta	NNP
cord-015021-pol2qm74	2482	19	ex	ex	NN
cord-015021-pol2qm74	2482	20	vivo	vivo	NN
cord-015021-pol2qm74	2482	21	.	.	.
cord-015021-pol2qm74	2483	1	The	the	DT
cord-015021-pol2qm74	2483	2	hyporeactivity	hyporeactivity	NN
cord-015021-pol2qm74	2483	3	to	to	IN
cord-015021-pol2qm74	2483	4	NA	NA	NNP
cord-015021-pol2qm74	2483	5	was	be	VBD
cord-015021-pol2qm74	2483	6	partially	partially	RB
cord-015021-pol2qm74	2483	7	restored	restore	VBN
cord-015021-pol2qm74	2483	8	by	by	IN
cord-015021-pol2qm74	2483	9	in	in	IN
cord-015021-pol2qm74	2483	10	vitro	vitro	FW
cord-015021-pol2qm74	2483	11	treatment	treatment	NN
cord-015021-pol2qm74	2483	12	of	of	IN
cord-015021-pol2qm74	2483	13	the	the	DT
cord-015021-pol2qm74	2483	14	vessels	vessel	NNS
cord-015021-pol2qm74	2483	15	with	with	IN
cord-015021-pol2qm74	2483	16	NG	NG	NNP
cord-015021-pol2qm74	2483	17	-	-	HYPH
cord-015021-pol2qm74	2483	18	nitro	nitro	NNP
cord-015021-pol2qm74	2483	19	-	-	HYPH
cord-015021-pol2qm74	2483	20	L	l	NN
cord-015021-pol2qm74	2483	21	-	-	HYPH
cord-015021-pol2qm74	2483	22	arginine	arginine	NN
cord-015021-pol2qm74	2483	23	methyl	methyl	NN
cord-015021-pol2qm74	2483	24	ester	ester	NN
cord-015021-pol2qm74	2483	25	(	(	-LRB-
cord-015021-pol2qm74	2483	26	L	l	NN
cord-015021-pol2qm74	2483	27	-	-	HYPH
cord-015021-pol2qm74	2483	28	NAME	NAME	NNP
cord-015021-pol2qm74	2483	29	,	,	,
cord-015021-pol2qm74	2483	30	20	20	CD
cord-015021-pol2qm74	2483	31	min	min	NN
cord-015021-pol2qm74	2483	32	,	,	,
cord-015021-pol2qm74	2483	33	3x10	3x10	CD
cord-015021-pol2qm74	2483	34	-4	-4	NNP
cord-015021-pol2qm74	2483	35	M	M	NNP
cord-015021-pol2qm74	2483	36	)	)	-RRB-
cord-015021-pol2qm74	2483	37	.	.	.
cord-015021-pol2qm74	2484	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	2484	2	of	of	IN
cord-015021-pol2qm74	2484	3	rats	rat	NNS
cord-015021-pol2qm74	2484	4	with	with	IN
cord-015021-pol2qm74	2484	5	TNFab	TNFab	NNP
cord-015021-pol2qm74	2484	6	or	or	CC
cord-015021-pol2qm74	2484	7	IL	IL	NNP
cord-015021-pol2qm74	2484	8	-	-	:
cord-015021-pol2qm74	2484	9	Ira	Ira	NNP
cord-015021-pol2qm74	2484	10	significantly	significantly	RB
cord-015021-pol2qm74	2484	11	(	(	-LRB-
cord-015021-pol2qm74	2484	12	p<0.05	p<0.05	JJ
cord-015021-pol2qm74	2484	13	)	)	-RRB-
cord-015021-pol2qm74	2484	14	prevented	prevent	VBD
cord-015021-pol2qm74	2484	15	the	the	DT
cord-015021-pol2qm74	2484	16	LPS	LPS	NNP
cord-015021-pol2qm74	2484	17	-	-	HYPH
cord-015021-pol2qm74	2484	18	induced	induce	VBN
cord-015021-pol2qm74	2484	19	hyporeactivity	hyporeactivity	NN
cord-015021-pol2qm74	2484	20	of	of	IN
cord-015021-pol2qm74	2484	21	rat	rat	NN
cord-015021-pol2qm74	2484	22	aortic	aortic	JJ
cord-015021-pol2qm74	2484	23	rings	ring	NNS
cord-015021-pol2qm74	2484	24	ex	ex	NN
cord-015021-pol2qm74	2484	25	vivo	vivo	NN
cord-015021-pol2qm74	2484	26	.	.	.
cord-015021-pol2qm74	2485	1	L	L	NNP
cord-015021-pol2qm74	2485	2	-	-	HYPH
cord-015021-pol2qm74	2485	3	NAME	NAME	NNP
cord-015021-pol2qm74	2485	4	did	do	VBD
cord-015021-pol2qm74	2485	5	not	not	RB
cord-015021-pol2qm74	2485	6	alter	alter	VB
cord-015021-pol2qm74	2485	7	or	or	CC
cord-015021-pol2qm74	2485	8	only	only	RB
cord-015021-pol2qm74	2485	9	slightly	slightly	RB
cord-015021-pol2qm74	2485	10	enhanced	enhance	VBD
cord-015021-pol2qm74	2485	11	the	the	DT
cord-015021-pol2qm74	2485	12	contractions	contraction	NNS
cord-015021-pol2qm74	2485	13	of	of	IN
cord-015021-pol2qm74	2485	14	aortic	aortic	JJ
cord-015021-pol2qm74	2485	15	rings	ring	NNS
cord-015021-pol2qm74	2485	16	obtained	obtain	VBN
cord-015021-pol2qm74	2485	17	from	from	IN
cord-015021-pol2qm74	2485	18	TNFab	TNFab	NNP
cord-015021-pol2qm74	2485	19	or	or	CC
cord-015021-pol2qm74	2485	20	IL	IL	NNP
cord-015021-pol2qm74	2485	21	-	-	HYPH
cord-015021-pol2qm74	2485	22	ira	ira	NNP
cord-015021-pol2qm74	2485	23	treated	treat	VBD
cord-015021-pol2qm74	2485	24	LPS	LPS	NNP
cord-015021-pol2qm74	2485	25	-	-	HYPH
cord-015021-pol2qm74	2485	26	rats	rat	NNS
cord-015021-pol2qm74	2485	27	,	,	,
cord-015021-pol2qm74	2485	28	respectively	respectively	RB
cord-015021-pol2qm74	2485	29	.	.	.
cord-015021-pol2qm74	2486	1	At	at	IN
cord-015021-pol2qm74	2486	2	180	180	CD
cord-015021-pol2qm74	2486	3	min	min	NN
cord-015021-pol2qm74	2486	4	after	after	IN
cord-015021-pol2qm74	2486	5	LPS	LPS	NNP
cord-015021-pol2qm74	2486	6	there	there	EX
cord-015021-pol2qm74	2486	7	was	be	VBD
cord-015021-pol2qm74	2486	8	an	an	DT
cord-015021-pol2qm74	2486	9	induction	induction	NN
cord-015021-pol2qm74	2486	10	of	of	IN
cord-015021-pol2qm74	2486	11	calcium	calcium	NN
cord-015021-pol2qm74	2486	12	-	-	HYPH
cord-015021-pol2qm74	2486	13	independent	independent	JJ
cord-015021-pol2qm74	2486	14	NOS	NOS	NNP
cord-015021-pol2qm74	2486	15	activity	activity	NN
cord-015021-pol2qm74	2486	16	in	in	IN
cord-015021-pol2qm74	2486	17	the	the	DT
cord-015021-pol2qm74	2486	18	lung	lung	NN
cord-015021-pol2qm74	2486	19	(	(	-LRB-
cord-015021-pol2qm74	2486	20	5.14-+0.57	5.14-+0.57	CD
cord-015021-pol2qm74	2486	21	pmol	pmol	JJ
cord-015021-pol2qm74	2486	22	citrulline	citrulline	NNP
cord-015021-pol2qm74	2486	23	/	/	SYM
cord-015021-pol2qm74	2486	24	mg	mg	NNP
cord-015021-pol2qm74	2486	25	/	/	SYM
cord-015021-pol2qm74	2486	26	min	min	NNP
cord-015021-pol2qm74	2486	27	,	,	,
cord-015021-pol2qm74	2486	28	n=8	n=8	NNP
cord-015021-pol2qm74	2486	29	)	)	-RRB-
cord-015021-pol2qm74	2486	30	,	,	,
cord-015021-pol2qm74	2486	31	which	which	WDT
cord-015021-pol2qm74	2486	32	was	be	VBD
cord-015021-pol2qm74	2486	33	attenuated	attenuate	VBN
cord-015021-pol2qm74	2486	34	by	by	IN
cord-015021-pol2qm74	2486	35	TNFab	TNFab	NNP
cord-015021-pol2qm74	2486	36	and	and	CC
cord-015021-pol2qm74	2486	37	!	!	.
cord-015021-pol2qm74	2487	1	L	L	NNP
cord-015021-pol2qm74	2487	2	-	-	HYPH
cord-015021-pol2qm74	2487	3	ira	ira	NNP
cord-015021-pol2qm74	2487	4	by	by	IN
cord-015021-pol2qm74	2487	5	37-+6	37-+6	CD
cord-015021-pol2qm74	2487	6	%	%	NN
cord-015021-pol2qm74	2487	7	and	and	CC
cord-015021-pol2qm74	2487	8	46-+6	46-+6	CD
cord-015021-pol2qm74	2487	9	%	%	NN
cord-015021-pol2qm74	2487	10	,	,	,
cord-015021-pol2qm74	2487	11	respectively	respectively	RB
cord-015021-pol2qm74	2487	12	(	(	-LRB-
cord-015021-pol2qm74	2487	13	n=5	n=5	JJ
cord-015021-pol2qm74	2487	14	;	;	:
cord-015021-pol2qm74	2487	15	p<0.05	p<0.05	CD
cord-015021-pol2qm74	2487	16	)	)	-RRB-
cord-015021-pol2qm74	2487	17	.	.	.
cord-015021-pol2qm74	2488	1	Thus	thus	RB
cord-015021-pol2qm74	2488	2	,	,	,
cord-015021-pol2qm74	2488	3	the	the	DT
cord-015021-pol2qm74	2488	4	production	production	NN
cord-015021-pol2qm74	2488	5	of	of	IN
cord-015021-pol2qm74	2488	6	both	both	CC
cord-015021-pol2qm74	2488	7	TNF	TNF	NNP
cord-015021-pol2qm74	2488	8	and	and	CC
cord-015021-pol2qm74	2488	9	IL	IL	NNP
cord-015021-pol2qm74	2488	10	-	-	:
cord-015021-pol2qm74	2488	11	I	-PRON-	PRP
cord-015021-pol2qm74	2488	12	contributes	contribute	VBZ
cord-015021-pol2qm74	2488	13	to	to	IN
cord-015021-pol2qm74	2488	14	the	the	DT
cord-015021-pol2qm74	2488	15	induction	induction	NN
cord-015021-pol2qm74	2488	16	of	of	IN
cord-015021-pol2qm74	2488	17	NOS	NOS	NNP
cord-015021-pol2qm74	2488	18	by	by	IN
cord-015021-pol2qm74	2488	19	LPS	LPS	NNP
cord-015021-pol2qm74	2488	20	in	in	IN
cord-015021-pol2qm74	2488	21	vivo	vivo	NN
cord-015021-pol2qm74	2488	22	.	.	.
cord-015021-pol2qm74	2489	1	The	the	DT
cord-015021-pol2qm74	2489	2	protective	protective	JJ
cord-015021-pol2qm74	2489	3	effect	effect	NN
cord-015021-pol2qm74	2489	4	of	of	IN
cord-015021-pol2qm74	2489	5	agents	agent	NNS
cord-015021-pol2qm74	2489	6	which	which	WDT
cord-015021-pol2qm74	2489	7	inhibit	inhibit	VBP
cord-015021-pol2qm74	2489	8	the	the	DT
cord-015021-pol2qm74	2489	9	release	release	NN
cord-015021-pol2qm74	2489	10	or	or	CC
cord-015021-pol2qm74	2489	11	action	action	NN
cord-015021-pol2qm74	2489	12	of	of	IN
cord-015021-pol2qm74	2489	13	TNF	TNF	NNP
cord-015021-pol2qm74	2489	14	or	or	CC
cord-015021-pol2qm74	2489	15	IL	IL	NNP
cord-015021-pol2qm74	2489	16	-	-	:
cord-015021-pol2qm74	2489	17	I	-PRON-	PRP
cord-015021-pol2qm74	2489	18	in	in	IN
cord-015021-pol2qm74	2489	19	shock	shock	NN
cord-015021-pol2qm74	2489	20	may	may	MD
cord-015021-pol2qm74	2489	21	be	be	VB
cord-015021-pol2qm74	2489	22	,	,	,
cord-015021-pol2qm74	2489	23	in	in	IN
cord-015021-pol2qm74	2489	24	part	part	NN
cord-015021-pol2qm74	2489	25	,	,	,
cord-015021-pol2qm74	2489	26	due	due	IN
cord-015021-pol2qm74	2489	27	to	to	IN
cord-015021-pol2qm74	2489	28	inhibition	inhibition	NN
cord-015021-pol2qm74	2489	29	of	of	IN
cord-015021-pol2qm74	2489	30	NOS	NOS	NNP
cord-015021-pol2qm74	2489	31	induction	induction	NN
cord-015021-pol2qm74	2489	32	.	.	.
cord-015021-pol2qm74	2490	1	Neal	Neal	NNP
cord-015021-pol2qm74	2490	2	Garrison	Garrison	NNP
cord-015021-pol2qm74	2490	3	,	,	,
cord-015021-pol2qm74	2490	4	MD	MD	NNP
cord-015021-pol2qm74	2490	5	Objective	Objective	NNP
cord-015021-pol2qm74	2490	6	:	:	:
cord-015021-pol2qm74	2491	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	2491	2	is	be	VBZ
cord-015021-pol2qm74	2491	3	often	often	RB
cord-015021-pol2qm74	2491	4	accompanied	accompany	VBN
cord-015021-pol2qm74	2491	5	by	by	IN
cord-015021-pol2qm74	2491	6	organ	organ	NN
cord-015021-pol2qm74	2491	7	dysfunction	dysfunction	NN
cord-015021-pol2qm74	2491	8	,	,	,
cord-015021-pol2qm74	2491	9	in	in	IN
cord-015021-pol2qm74	2491	10	part	part	NN
cord-015021-pol2qm74	2491	11	due	due	IN
cord-015021-pol2qm74	2491	12	to	to	IN
cord-015021-pol2qm74	2491	13	impaired	impaired	JJ
cord-015021-pol2qm74	2491	14	microvascular	microvascular	JJ
cord-015021-pol2qm74	2491	15	perfusion	perfusion	NN
cord-015021-pol2qm74	2491	16	.	.	.
cord-015021-pol2qm74	2492	1	Recently	recently	RB
cord-015021-pol2qm74	2492	2	,	,	,
cord-015021-pol2qm74	2492	3	nitric	nitric	JJ
cord-015021-pol2qm74	2492	4	oxide	oxide	NN
cord-015021-pol2qm74	2492	5	(	(	-LRB-
cord-015021-pol2qm74	2492	6	NO	no	UH
cord-015021-pol2qm74	2492	7	)	)	-RRB-
cord-015021-pol2qm74	2492	8	has	have	VBZ
cord-015021-pol2qm74	2492	9	been	be	VBN
cord-015021-pol2qm74	2492	10	described	describe	VBN
cord-015021-pol2qm74	2492	11	as	as	IN
cord-015021-pol2qm74	2492	12	an	an	DT
cord-015021-pol2qm74	2492	13	important	important	JJ
cord-015021-pol2qm74	2492	14	mediator	mediator	NN
cord-015021-pol2qm74	2492	15	of	of	IN
cord-015021-pol2qm74	2492	16	the	the	DT
cord-015021-pol2qm74	2492	17	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	2492	18	changes	change	NNS
cord-015021-pol2qm74	2492	19	of	of	IN
cord-015021-pol2qm74	2492	20	sepsis	sepsis	NN
cord-015021-pol2qm74	2492	21	,	,	,
cord-015021-pol2qm74	2492	22	and	and	CC
cord-015021-pol2qm74	2492	23	NO	no	DT
cord-015021-pol2qm74	2492	24	synthase	synthase	NN
cord-015021-pol2qm74	2492	25	(	(	-LRB-
cord-015021-pol2qm74	2492	26	NO	NO	NNP
cord-015021-pol2qm74	2492	27	-	-	HYPH
cord-015021-pol2qm74	2492	28	S	S	NNP
cord-015021-pol2qm74	2492	29	)	)	-RRB-
cord-015021-pol2qm74	2492	30	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	2492	31	have	have	VBP
cord-015021-pol2qm74	2492	32	been	be	VBN
cord-015021-pol2qm74	2492	33	advocated	advocate	VBN
cord-015021-pol2qm74	2492	34	for	for	IN
cord-015021-pol2qm74	2492	35	treatment	treatment	NN
cord-015021-pol2qm74	2492	36	of	of	IN
cord-015021-pol2qm74	2492	37	septic	septic	JJ
cord-015021-pol2qm74	2492	38	shock	shock	NN
cord-015021-pol2qm74	2492	39	,	,	,
cord-015021-pol2qm74	2492	40	but	but	CC
cord-015021-pol2qm74	2492	41	their	-PRON-	PRP$
cord-015021-pol2qm74	2492	42	visceral	visceral	JJ
cord-015021-pol2qm74	2492	43	microcirculatory	microcirculatory	JJ
cord-015021-pol2qm74	2492	44	effects	effect	NNS
cord-015021-pol2qm74	2492	45	are	be	VBP
cord-015021-pol2qm74	2492	46	inadequately	inadequately	RB
cord-015021-pol2qm74	2492	47	characterized	characterize	VBN
cord-015021-pol2qm74	2492	48	.	.	.
cord-015021-pol2qm74	2493	1	We	-PRON-	PRP
cord-015021-pol2qm74	2493	2	postulated	postulate	VBD
cord-015021-pol2qm74	2493	3	that	that	IN
cord-015021-pol2qm74	2493	4	NO	NO	NNP
cord-015021-pol2qm74	2493	5	-	-	HYPH
cord-015021-pol2qm74	2493	6	S	s	NN
cord-015021-pol2qm74	2493	7	inhibition	inhibition	NN
cord-015021-pol2qm74	2493	8	would	would	MD
cord-015021-pol2qm74	2493	9	EXaCErbatE	EXaCErbatE	NNP
cord-015021-pol2qm74	2493	10	the	the	DT
cord-015021-pol2qm74	2493	11	impaired	impaired	JJ
cord-015021-pol2qm74	2493	12	organ	organ	NN
cord-015021-pol2qm74	2493	13	pErfusion	perfusion	NN
cord-015021-pol2qm74	2493	14	of	of	IN
cord-015021-pol2qm74	2493	15	sepsis	sepsis	NN
cord-015021-pol2qm74	2493	16	.	.	.
cord-015021-pol2qm74	2494	1	Methods	method	NNS
cord-015021-pol2qm74	2494	2	:	:	:
cord-015021-pol2qm74	2494	3	Six	six	CD
cord-015021-pol2qm74	2494	4	groups	group	NNS
cord-015021-pol2qm74	2494	5	ofdecerebratE	ofdecerebrate	VBP
cord-015021-pol2qm74	2494	6	rats	rat	NNS
cord-015021-pol2qm74	2494	7	were	be	VBD
cord-015021-pol2qm74	2494	8	studied	study	VBN
cord-015021-pol2qm74	2494	9	.	.	.
cord-015021-pol2qm74	2495	1	Bacteremia	Bacteremia	NNP
cord-015021-pol2qm74	2495	2	was	be	VBD
cord-015021-pol2qm74	2495	3	induced	induce	VBN
cord-015021-pol2qm74	2495	4	with	with	IN
cord-015021-pol2qm74	2495	5	109	109	CD
cord-015021-pol2qm74	2495	6	live	live	JJ
cord-015021-pol2qm74	2495	7	E.	E.	NNP
cord-015021-pol2qm74	2495	8	coli	coli	NNS
cord-015021-pol2qm74	2495	9	,	,	,
cord-015021-pol2qm74	2495	10	which	which	WDT
cord-015021-pol2qm74	2495	11	consistently	consistently	RB
cord-015021-pol2qm74	2495	12	increased	increase	VBD
cord-015021-pol2qm74	2495	13	cardiac	cardiac	JJ
cord-015021-pol2qm74	2495	14	output	output	NN
cord-015021-pol2qm74	2495	15	15	15	CD
cord-015021-pol2qm74	2495	16	-	-	SYM
cord-015021-pol2qm74	2495	17	20	20	CD
cord-015021-pol2qm74	2495	18	%	%	NN
cord-015021-pol2qm74	2495	19	above	above	IN
cord-015021-pol2qm74	2495	20	baseline	baseline	NN
cord-015021-pol2qm74	2495	21	(	(	-LRB-
cord-015021-pol2qm74	2495	22	BL	BL	NNP
cord-015021-pol2qm74	2495	23	)	)	-RRB-
cord-015021-pol2qm74	2495	24	.	.	.
cord-015021-pol2qm74	2496	1	The	the	DT
cord-015021-pol2qm74	2496	2	NO	NO	NNP
cord-015021-pol2qm74	2496	3	-	-	HYPH
cord-015021-pol2qm74	2496	4	S	s	NN
cord-015021-pol2qm74	2496	5	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2496	6	Nm	Nm	NNP
cord-015021-pol2qm74	2496	7	-	-	HYPH
cord-015021-pol2qm74	2496	8	nitro	nitro	NNP
cord-015021-pol2qm74	2496	9	-	-	HYPH
cord-015021-pol2qm74	2496	10	Larginine	larginine	JJ
cord-015021-pol2qm74	2496	11	methyl	methyl	NN
cord-015021-pol2qm74	2496	12	ester	ester	NN
cord-015021-pol2qm74	2496	13	(	(	-LRB-
cord-015021-pol2qm74	2496	14	L	L	NNP
cord-015021-pol2qm74	2496	15	-	-	HYPH
cord-015021-pol2qm74	2496	16	NAME,1	NAME,1	NNP
cord-015021-pol2qm74	2496	17	mg	mg	NNP
cord-015021-pol2qm74	2496	18	/	/	SYM
cord-015021-pol2qm74	2496	19	kg	kg	NNP
cord-015021-pol2qm74	2496	20	IV	IV	NNP
cord-015021-pol2qm74	2496	21	)	)	-RRB-
cord-015021-pol2qm74	2496	22	,	,	,
cord-015021-pol2qm74	2496	23	prevented	prevent	VBD
cord-015021-pol2qm74	2496	24	this	this	DT
cord-015021-pol2qm74	2496	25	increase	increase	NN
cord-015021-pol2qm74	2496	26	and	and	CC
cord-015021-pol2qm74	2496	27	elevated	elevated	JJ
cord-015021-pol2qm74	2496	28	MAP	map	NN
cord-015021-pol2qm74	2496	29	by	by	IN
cord-015021-pol2qm74	2496	30	25	25	CD
cord-015021-pol2qm74	2496	31	-	-	SYM
cord-015021-pol2qm74	2496	32	30	30	CD
cord-015021-pol2qm74	2496	33	%	%	NN
cord-015021-pol2qm74	2496	34	.	.	.
cord-015021-pol2qm74	2497	1	In	in	IN
cord-015021-pol2qm74	2497	2	the	the	DT
cord-015021-pol2qm74	2497	3	first	first	JJ
cord-015021-pol2qm74	2497	4	3	3	CD
cord-015021-pol2qm74	2497	5	groups	group	NNS
cord-015021-pol2qm74	2497	6	,	,	,
cord-015021-pol2qm74	2497	7	total	total	JJ
cord-015021-pol2qm74	2497	8	hepatic	hepatic	JJ
cord-015021-pol2qm74	2497	9	blood	blood	NN
cord-015021-pol2qm74	2497	10	flow	flow	NN
cord-015021-pol2qm74	2497	11	(	(	-LRB-
cord-015021-pol2qm74	2497	12	THBF	THBF	NNP
cord-015021-pol2qm74	2497	13	,	,	,
cord-015021-pol2qm74	2497	14	ml	ml	NN
cord-015021-pol2qm74	2497	15	/	/	SYM
cord-015021-pol2qm74	2497	16	min	min	NN
cord-015021-pol2qm74	2497	17	by	by	IN
cord-015021-pol2qm74	2497	18	time	time	NN
cord-015021-pol2qm74	2497	19	transit	transit	NNP
cord-015021-pol2qm74	2497	20	flowmetry	flowmetry	NNP
cord-015021-pol2qm74	2497	21	)	)	-RRB-
cord-015021-pol2qm74	2497	22	and	and	CC
cord-015021-pol2qm74	2497	23	microvascular	microvascular	JJ
cord-015021-pol2qm74	2497	24	perfusion	perfusion	NN
cord-015021-pol2qm74	2497	25	(	(	-LRB-
cord-015021-pol2qm74	2497	26	MI	MI	NNP
cord-015021-pol2qm74	2497	27	-	-	HYPH
cord-015021-pol2qm74	2497	28	IBF	IBF	NNP
cord-015021-pol2qm74	2497	29	,	,	,
cord-015021-pol2qm74	2497	30	¼	¼	NN
cord-015021-pol2qm74	2497	31	BL	bl	NN
cord-015021-pol2qm74	2497	32	by	by	IN
cord-015021-pol2qm74	2497	33	laser	laser	NN
cord-015021-pol2qm74	2497	34	Doppler	doppler	NN
cord-015021-pol2qm74	2497	35	flux	flux	NN
cord-015021-pol2qm74	2497	36	)	)	-RRB-
cord-015021-pol2qm74	2497	37	were	be	VBD
cord-015021-pol2qm74	2497	38	measured	measure	VBN
cord-015021-pol2qm74	2497	39	.	.	.
cord-015021-pol2qm74	2498	1	In	in	IN
cord-015021-pol2qm74	2498	2	the	the	DT
cord-015021-pol2qm74	2498	3	other	other	JJ
cord-015021-pol2qm74	2498	4	3	3	CD
cord-015021-pol2qm74	2498	5	groups	group	NNS
cord-015021-pol2qm74	2498	6	,	,	,
cord-015021-pol2qm74	2498	7	in	in	IN
cord-015021-pol2qm74	2498	8	vivo	vivo	NNP
cord-015021-pol2qm74	2498	9	videomicroscopy	videomicroscopy	NNP
cord-015021-pol2qm74	2498	10	was	be	VBD
cord-015021-pol2qm74	2498	11	used	use	VBN
cord-015021-pol2qm74	2498	12	to	to	TO
cord-015021-pol2qm74	2498	13	observe	observe	VB
cord-015021-pol2qm74	2498	14	renal	renal	JJ
cord-015021-pol2qm74	2498	15	microvascular	microvascular	JJ
cord-015021-pol2qm74	2498	16	responses	response	NNS
cord-015021-pol2qm74	2498	17	(	(	-LRB-
cord-015021-pol2qm74	2498	18	ILA	ILA	NNP
cord-015021-pol2qm74	2498	19	=	=	SYM
cord-015021-pol2qm74	2498	20	interlobular	interlobular	JJ
cord-015021-pol2qm74	2498	21	artery	artery	NN
cord-015021-pol2qm74	2498	22	,	,	,
cord-015021-pol2qm74	2498	23	AFF	AFF	NNP
cord-015021-pol2qm74	2498	24	=	=	SYM
cord-015021-pol2qm74	2498	25	afferent	afferent	NN
cord-015021-pol2qm74	2498	26	arteriole	arteriole	NN
cord-015021-pol2qm74	2498	27	,	,	,
cord-015021-pol2qm74	2498	28	EFF	eff	NN
cord-015021-pol2qm74	2498	29	=	=	SYM
cord-015021-pol2qm74	2498	30	efferent	efferent	JJ
cord-015021-pol2qm74	2498	31	arteriole	arteriole	NN
cord-015021-pol2qm74	2498	32	;	;	:
cord-015021-pol2qm74	2498	33	%	%	NN
cord-015021-pol2qm74	2498	34	BL	bl	NN
cord-015021-pol2qm74	2498	35	for	for	IN
cord-015021-pol2qm74	2498	36	all	all	DT
cord-015021-pol2qm74	2498	37	)	)	-RRB-
cord-015021-pol2qm74	2498	38	.	.	.
cord-015021-pol2qm74	2499	1	Results	result	NNS
cord-015021-pol2qm74	2499	2	:	:	:
cord-015021-pol2qm74	2500	1	Data	datum	NNS
cord-015021-pol2qm74	2500	2	are	be	VBP
cord-015021-pol2qm74	2500	3	60	60	CD
cord-015021-pol2qm74	2500	4	rains	rain	NNS
cord-015021-pol2qm74	2500	5	after	after	IN
cord-015021-pol2qm74	2500	6	E.	E.	NNP
cord-015021-pol2qm74	2500	7	coB.	coB.	VBD
cord-015021-pol2qm74	2500	8	N=5	N=5	NNP
cord-015021-pol2qm74	2500	9	-	-	HYPH
cord-015021-pol2qm74	2500	10	7	7	CD
cord-015021-pol2qm74	2500	11	/	/	SYM
cord-015021-pol2qm74	2500	12	group	group	NN
cord-015021-pol2qm74	2500	13	.	.	.
cord-015021-pol2qm74	2501	1	*	*	NFP
cord-015021-pol2qm74	2501	2	p<0.05	p<0.05	NN
cord-015021-pol2qm74	2501	3	vs	vs	IN
cord-015021-pol2qm74	2501	4	BL	BL	NNP
cord-015021-pol2qm74	2501	5	by	by	IN
cord-015021-pol2qm74	2501	6	REMANOVA	REMANOVA	NNP
cord-015021-pol2qm74	2501	7	and	and	CC
cord-015021-pol2qm74	2501	8	§	§	CD
cord-015021-pol2qm74	2501	9	p<0.05	p<0.05	NN
cord-015021-pol2qm74	2501	10	vs	vs	IN
cord-015021-pol2qm74	2501	11	E.	E.	NNP
cord-015021-pol2qm74	2501	12	coli	coli	NNS
cord-015021-pol2qm74	2501	13	alone	alone	JJ
cord-015021-pol2qm74	2501	14	by	by	IN
cord-015021-pol2qm74	2501	15	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	2501	16	.	.	.
cord-015021-pol2qm74	2502	1	EC+L	EC+L	NNP
cord-015021-pol2qm74	2502	2	-	-	HYPH
cord-015021-pol2qm74	2502	3	NAME	NAME	NNP
cord-015021-pol2qm74	2503	1	11-+2	11-+2	CD
cord-015021-pol2qm74	2503	2	-57_+10	-57_+10	NN
cord-015021-pol2qm74	2503	3	"	"	''
cord-015021-pol2qm74	2504	1	§	§	.
cord-015021-pol2qm74	2505	1	-45_+4	-45_+4	NNP
cord-015021-pol2qm74	2506	1	*	*	NFP
cord-015021-pol2qm74	2506	2	§	§	NFP
cord-015021-pol2qm74	2506	3	-89_+3	-89_+3	:
cord-015021-pol2qm74	2507	1	*	*	NFP
cord-015021-pol2qm74	2507	2	§	§	,
cord-015021-pol2qm74	2507	3	-33	-33	NNP
cord-015021-pol2qm74	2508	1	+5	+5	NFP
cord-015021-pol2qm74	2509	1	*	*	NFP
cord-015021-pol2qm74	2509	2	-20	-20	NFP
cord-015021-pol2qm74	2509	3	+	+	.
cord-015021-pol2qm74	2510	1	5	5	LS
cord-015021-pol2qm74	2511	1	*	*	NFP
cord-015021-pol2qm74	2511	2	§	§	.
cord-015021-pol2qm74	2511	3	Conclusions	conclusion	NNS
cord-015021-pol2qm74	2511	4	:	:	:
cord-015021-pol2qm74	2511	5	L	L	NNP
cord-015021-pol2qm74	2511	6	-	-	HYPH
cord-015021-pol2qm74	2511	7	NAME	NAME	NNP
cord-015021-pol2qm74	2511	8	administration	administration	NN
cord-015021-pol2qm74	2511	9	in	in	IN
cord-015021-pol2qm74	2511	10	controls	control	NNS
cord-015021-pol2qm74	2511	11	decreased	decrease	VBD
cord-015021-pol2qm74	2511	12	renal	renal	JJ
cord-015021-pol2qm74	2511	13	blood	blood	NN
cord-015021-pol2qm74	2511	14	flow	flow	NN
cord-015021-pol2qm74	2511	15	,	,	,
cord-015021-pol2qm74	2511	16	indicating	indicate	VBG
cord-015021-pol2qm74	2511	17	NO	no	DT
cord-015021-pol2qm74	2511	18	contributes	contribute	VBZ
cord-015021-pol2qm74	2511	19	to	to	IN
cord-015021-pol2qm74	2511	20	basal	basal	NN
cord-015021-pol2qm74	2511	21	renal	renal	JJ
cord-015021-pol2qm74	2511	22	tone	tone	NN
cord-015021-pol2qm74	2511	23	.	.	.
cord-015021-pol2qm74	2512	1	Bacteremia	Bacteremia	NNP
cord-015021-pol2qm74	2512	2	decreased	decrease	VBD
cord-015021-pol2qm74	2512	3	MtlBF	MtlBF	NNS
cord-015021-pol2qm74	2512	4	but	but	CC
cord-015021-pol2qm74	2512	5	not	not	RB
cord-015021-pol2qm74	2512	6	THBF	THBF	NNP
cord-015021-pol2qm74	2512	7	,	,	,
cord-015021-pol2qm74	2512	8	and	and	CC
cord-015021-pol2qm74	2512	9	MI	MI	NNP
cord-015021-pol2qm74	2512	10	-	-	HYPH
cord-015021-pol2qm74	2512	11	IBF	IBF	NNP
cord-015021-pol2qm74	2512	12	was	be	VBD
cord-015021-pol2qm74	2512	13	further	further	RB
cord-015021-pol2qm74	2512	14	impaired	impair	VBN
cord-015021-pol2qm74	2512	15	by	by	IN
cord-015021-pol2qm74	2512	16	NO	no	DT
cord-015021-pol2qm74	2512	17	-	-	HYPH
cord-015021-pol2qm74	2512	18	S	s	NN
cord-015021-pol2qm74	2512	19	inhibition	inhibition	NN
cord-015021-pol2qm74	2512	20	.	.	.
cord-015021-pol2qm74	2513	1	E.	E.	NNP
cord-015021-pol2qm74	2513	2	coli	coli	NNS
cord-015021-pol2qm74	2513	3	caused	cause	VBD
cord-015021-pol2qm74	2513	4	renal	renal	JJ
cord-015021-pol2qm74	2513	5	preglomemlar	preglomemlar	NN
cord-015021-pol2qm74	2513	6	,	,	,
cord-015021-pol2qm74	2513	7	but	but	CC
cord-015021-pol2qm74	2513	8	not	not	RB
cord-015021-pol2qm74	2513	9	postglomerular	postglomerular	JJ
cord-015021-pol2qm74	2513	10	constriction	constriction	NN
cord-015021-pol2qm74	2513	11	and	and	CC
cord-015021-pol2qm74	2513	12	reduced	reduced	JJ
cord-015021-pol2qm74	2513	13	flow	flow	NN
cord-015021-pol2qm74	2513	14	.	.	.
cord-015021-pol2qm74	2514	1	L	l	NN
cord-015021-pol2qm74	2514	2	-	-	HYPH
cord-015021-pol2qm74	2514	3	NAME	name	NN
cord-015021-pol2qm74	2514	4	exacerbated	exacerbate	VBD
cord-015021-pol2qm74	2514	5	these	these	DT
cord-015021-pol2qm74	2514	6	E.	E.	NNP
cord-015021-pol2qm74	2514	7	coli	coli	NNS
cord-015021-pol2qm74	2514	8	-	-	HYPH
cord-015021-pol2qm74	2514	9	induced	induce	VBN
cord-015021-pol2qm74	2514	10	alterations	alteration	NNS
cord-015021-pol2qm74	2514	11	and	and	CC
cord-015021-pol2qm74	2514	12	caused	cause	VBD
cord-015021-pol2qm74	2514	13	EFF	eff	NN
cord-015021-pol2qm74	2514	14	constriction	constriction	NN
cord-015021-pol2qm74	2514	15	.	.	.
cord-015021-pol2qm74	2515	1	These	these	DT
cord-015021-pol2qm74	2515	2	data	datum	NNS
cord-015021-pol2qm74	2515	3	indicate	indicate	VBP
cord-015021-pol2qm74	2515	4	that	that	IN
cord-015021-pol2qm74	2515	5	NO	NO	NNP
cord-015021-pol2qm74	2515	6	-	-	HYPH
cord-015021-pol2qm74	2515	7	S	s	NN
cord-015021-pol2qm74	2515	8	inhibition	inhibition	NN
cord-015021-pol2qm74	2515	9	exacerbates	exacerbate	VBZ
cord-015021-pol2qm74	2515	10	bacteremia	bacteremia	NN
cord-015021-pol2qm74	2515	11	-	-	HYPH
cord-015021-pol2qm74	2515	12	induced	induce	VBN
cord-015021-pol2qm74	2515	13	impairment	impairment	NN
cord-015021-pol2qm74	2515	14	of	of	IN
cord-015021-pol2qm74	2515	15	renal	renal	JJ
cord-015021-pol2qm74	2515	16	and	and	CC
cord-015021-pol2qm74	2515	17	hepatic	hepatic	JJ
cord-015021-pol2qm74	2515	18	blood	blood	NN
cord-015021-pol2qm74	2515	19	flow	flow	NN
cord-015021-pol2qm74	2515	20	,	,	,
cord-015021-pol2qm74	2515	21	suggesting	suggest	VBG
cord-015021-pol2qm74	2515	22	that	that	IN
cord-015021-pol2qm74	2515	23	NO	no	DT
cord-015021-pol2qm74	2515	24	is	be	VBZ
cord-015021-pol2qm74	2515	25	an	an	DT
cord-015021-pol2qm74	2515	26	importam	importam	NNP
cord-015021-pol2qm74	2515	27	compensatory	compensatory	JJ
cord-015021-pol2qm74	2515	28	dilator	dilator	NN
cord-015021-pol2qm74	2515	29	mechanism	mechanism	NN
cord-015021-pol2qm74	2515	30	in	in	IN
cord-015021-pol2qm74	2515	31	these	these	DT
cord-015021-pol2qm74	2515	32	organs	organ	NNS
cord-015021-pol2qm74	2515	33	during	during	IN
cord-015021-pol2qm74	2515	34	sepsis	sepsis	NN
cord-015021-pol2qm74	2515	35	.	.	.
cord-015021-pol2qm74	2516	1	IRF	IRF	NNP
cord-015021-pol2qm74	2516	2	(	(	-LRB-
cord-015021-pol2qm74	2516	3	iron	iron	NN
cord-015021-pol2qm74	2516	4	responsive	responsive	JJ
cord-015021-pol2qm74	2516	5	factor	factor	NN
cord-015021-pol2qm74	2516	6	)	)	-RRB-
cord-015021-pol2qm74	2516	7	is	be	VBZ
cord-015021-pol2qm74	2516	8	the	the	DT
cord-015021-pol2qm74	2516	9	central	central	JJ
cord-015021-pol2qm74	2516	10	regulatory	regulatory	JJ
cord-015021-pol2qm74	2516	11	protein	protein	NN
cord-015021-pol2qm74	2516	12	of	of	IN
cord-015021-pol2qm74	2516	13	intracellular	intracellular	JJ
cord-015021-pol2qm74	2516	14	iron	iron	NN
cord-015021-pol2qm74	2516	15	metabolism	metabolism	NN
cord-015021-pol2qm74	2516	16	able	able	JJ
cord-015021-pol2qm74	2516	17	to	to	TO
cord-015021-pol2qm74	2516	18	bind	bind	VB
cord-015021-pol2qm74	2516	19	to	to	IN
cord-015021-pol2qm74	2516	20	responsive	responsive	JJ
cord-015021-pol2qm74	2516	21	RNA	RNA	NNP
cord-015021-pol2qm74	2516	22	elements	element	NNS
cord-015021-pol2qm74	2516	23	(	(	-LRB-
cord-015021-pol2qm74	2516	24	IREs	IREs	NNP
cord-015021-pol2qm74	2516	25	)	)	-RRB-
cord-015021-pol2qm74	2516	26	present	present	VBP
cord-015021-pol2qm74	2516	27	atthe	atthe	DT
cord-015021-pol2qm74	2516	28	5'untranslated	5'untranslated	CD
cord-015021-pol2qm74	2516	29	region	region	NN
cord-015021-pol2qm74	2516	30	(	(	-LRB-
cord-015021-pol2qm74	2516	31	UTR	UTR	NNP
cord-015021-pol2qm74	2516	32	)	)	-RRB-
cord-015021-pol2qm74	2516	33	of	of	IN
cord-015021-pol2qm74	2516	34	ferritin	ferritin	NNP
cord-015021-pol2qm74	2516	35	mRNA	mRNA	NNP
cord-015021-pol2qm74	2516	36	and	and	CC
cord-015021-pol2qm74	2516	37	3'UTR	3'utr	CD
cord-015021-pol2qm74	2516	38	of	of	IN
cord-015021-pol2qm74	2516	39	transferrin	transferrin	NN
cord-015021-pol2qm74	2516	40	receptor	receptor	NN
cord-015021-pol2qm74	2516	41	mRNA	mRNA	NNP
cord-015021-pol2qm74	2516	42	.	.	.
cord-015021-pol2qm74	2517	1	Binding	bind	VBG
cord-015021-pol2qm74	2517	2	of	of	IN
cord-015021-pol2qm74	2517	3	IRF	IRF	NNP
cord-015021-pol2qm74	2517	4	to	to	IN
cord-015021-pol2qm74	2517	5	IREs	ires	NN
cord-015021-pol2qm74	2517	6	results	result	NNS
cord-015021-pol2qm74	2517	7	in	in	IN
cord-015021-pol2qm74	2517	8	repression	repression	NN
cord-015021-pol2qm74	2517	9	of	of	IN
cord-015021-pol2qm74	2517	10	ferritin	ferritin	NN
cord-015021-pol2qm74	2517	11	mRNA	mRNA	NNP
cord-015021-pol2qm74	2517	12	translation	translation	NN
cord-015021-pol2qm74	2517	13	and	and	CC
cord-015021-pol2qm74	2517	14	increased	increase	VBN
cord-015021-pol2qm74	2517	15	stability	stability	NN
cord-015021-pol2qm74	2517	16	of	of	IN
cord-015021-pol2qm74	2517	17	transferrin	transferrin	NN
cord-015021-pol2qm74	2517	18	receptor	receptor	NN
cord-015021-pol2qm74	2517	19	mRNA	mrna	NN
cord-015021-pol2qm74	2517	20	leading	lead	VBG
cord-015021-pol2qm74	2517	21	to	to	IN
cord-015021-pol2qm74	2517	22	enhancement	enhancement	NN
cord-015021-pol2qm74	2517	23	of	of	IN
cord-015021-pol2qm74	2517	24	transferrin	transferrin	NN
cord-015021-pol2qm74	2517	25	receptor	receptor	NN
cord-015021-pol2qm74	2517	26	translation	translation	NN
cord-015021-pol2qm74	2517	27	.	.	.
cord-015021-pol2qm74	2518	1	We	-PRON-	PRP
cord-015021-pol2qm74	2518	2	describe	describe	VBP
cord-015021-pol2qm74	2518	3	here	here	RB
cord-015021-pol2qm74	2518	4	that	that	IN
cord-015021-pol2qm74	2518	5	either	either	CC
cord-015021-pol2qm74	2518	6	tetrahydrobiopterin	tetrahydrobiopterin	NN
cord-015021-pol2qm74	2518	7	dependent	dependent	JJ
cord-015021-pol2qm74	2518	8	stimulation	stimulation	NN
cord-015021-pol2qm74	2518	9	as	as	RB
cord-015021-pol2qm74	2518	10	well	well	RB
cord-015021-pol2qm74	2518	11	as	as	IN
cord-015021-pol2qm74	2518	12	cytokine	cytokine	NN
cord-015021-pol2qm74	2518	13	(	(	-LRB-
cord-015021-pol2qm74	2518	14	IFN-~)/lipopolysaccharidemediated	ifn-~)/lipopolysaccharidemediated	JJ
cord-015021-pol2qm74	2518	15	induction	induction	NN
cord-015021-pol2qm74	2518	16	of	of	IN
cord-015021-pol2qm74	2518	17	nitric	nitric	JJ
cord-015021-pol2qm74	2518	18	oxide	oxide	NN
cord-015021-pol2qm74	2518	19	synthase	synthase	NN
cord-015021-pol2qm74	2518	20	activates	activate	VBZ
cord-015021-pol2qm74	2518	21	IRF	IRF	NNP
cord-015021-pol2qm74	2518	22	,	,	,
cord-015021-pol2qm74	2518	23	which	which	WDT
cord-015021-pol2qm74	2518	24	is	be	VBZ
cord-015021-pol2qm74	2518	25	due	due	JJ
cord-015021-pol2qm74	2518	26	to	to	IN
cord-015021-pol2qm74	2518	27	direct	direct	JJ
cord-015021-pol2qm74	2518	28	interaction	interaction	NN
cord-015021-pol2qm74	2518	29	of	of	IN
cord-015021-pol2qm74	2518	30	nitric	nitric	NN
cord-015021-pol2qm74	2518	31	oxide	oxide	NN
cord-015021-pol2qm74	2518	32	with	with	IN
cord-015021-pol2qm74	2518	33	the	the	DT
cord-015021-pol2qm74	2518	34	iron	iron	NN
cord-015021-pol2qm74	2518	35	-	-	HYPH
cord-015021-pol2qm74	2518	36	sulphur	sulphur	NN
cord-015021-pol2qm74	2518	37	-	-	HYPH
cord-015021-pol2qm74	2518	38	cluster	cluster	NN
cord-015021-pol2qm74	2518	39	of	of	IN
cord-015021-pol2qm74	2518	40	IRF	IRF	NNP
cord-015021-pol2qm74	2518	41	.	.	.
cord-015021-pol2qm74	2519	1	This	this	DT
cord-015021-pol2qm74	2519	2	was	be	VBD
cord-015021-pol2qm74	2519	3	shown	show	VBN
cord-015021-pol2qm74	2519	4	by	by	IN
cord-015021-pol2qm74	2519	5	gene	gene	NN
cord-015021-pol2qm74	2519	6	expression	expression	NN
cord-015021-pol2qm74	2519	7	studies	study	NNS
cord-015021-pol2qm74	2519	8	using	use	VBG
cord-015021-pol2qm74	2519	9	a	a	DT
cord-015021-pol2qm74	2519	10	plasmid	plasmid	NN
cord-015021-pol2qm74	2519	11	containing	contain	VBG
cord-015021-pol2qm74	2519	12	a	a	DT
cord-015021-pol2qm74	2519	13	ferritin	ferritin	NN
cord-015021-pol2qm74	2519	14	IRE	ire	NN
cord-015021-pol2qm74	2519	15	and	and	CC
cord-015021-pol2qm74	2519	16	a	a	DT
cord-015021-pol2qm74	2519	17	CAT	cat	NN
cord-015021-pol2qm74	2519	18	indicator	indicator	NN
cord-015021-pol2qm74	2519	19	box	box	NN
cord-015021-pol2qm74	2519	20	which	which	WDT
cord-015021-pol2qm74	2519	21	was	be	VBD
cord-015021-pol2qm74	2519	22	transfected	transfecte	VBN
cord-015021-pol2qm74	2519	23	into	into	IN
cord-015021-pol2qm74	2519	24	K562	k562	CD
cord-015021-pol2qm74	2519	25	myelomonocytic	myelomonocytic	JJ
cord-015021-pol2qm74	2519	26	cells	cell	NNS
cord-015021-pol2qm74	2519	27	,	,	,
cord-015021-pol2qm74	2519	28	which	which	WDT
cord-015021-pol2qm74	2519	29	were	be	VBD
cord-015021-pol2qm74	2519	30	shown	show	VBN
cord-015021-pol2qm74	2519	31	to	to	TO
cord-015021-pol2qm74	2519	32	have	have	VB
cord-015021-pol2qm74	2519	33	a	a	DT
cord-015021-pol2qm74	2519	34	constitutive	constitutive	JJ
cord-015021-pol2qm74	2519	35	form	form	NN
cord-015021-pol2qm74	2519	36	of	of	IN
cord-015021-pol2qm74	2519	37	nitric	nitric	NN
cord-015021-pol2qm74	2519	38	oxide	oxide	NN
cord-015021-pol2qm74	2519	39	synthase	synthase	NN
cord-015021-pol2qm74	2519	40	(	(	-LRB-
cord-015021-pol2qm74	2519	41	NOS	NOS	NNP
cord-015021-pol2qm74	2519	42	)	)	-RRB-
cord-015021-pol2qm74	2519	43	.	.	.
cord-015021-pol2qm74	2520	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2520	2	,	,	,
cord-015021-pol2qm74	2520	3	the	the	DT
cord-015021-pol2qm74	2520	4	increased	increase	VBN
cord-015021-pol2qm74	2520	5	binding	binding	NN
cord-015021-pol2qm74	2520	6	of	of	IN
cord-015021-pol2qm74	2520	7	1RE	1re	CD
cord-015021-pol2qm74	2520	8	to	to	IN
cord-015021-pol2qm74	2520	9	IRF	IRF	NNP
cord-015021-pol2qm74	2520	10	due	due	IN
cord-015021-pol2qm74	2520	11	to	to	IN
cord-015021-pol2qm74	2520	12	IRF	IRF	NNP
cord-015021-pol2qm74	2520	13	activation	activation	NN
cord-015021-pol2qm74	2520	14	of	of	IN
cord-015021-pol2qm74	2520	15	IRF	IRF	NNP
cord-015021-pol2qm74	2520	16	by	by	IN
cord-015021-pol2qm74	2520	17	nitric	nitric	NN
cord-015021-pol2qm74	2520	18	oxide	oxide	NN
cord-015021-pol2qm74	2520	19	was	be	VBD
cord-015021-pol2qm74	2520	20	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2520	21	by	by	IN
cord-015021-pol2qm74	2520	22	gel	gel	NN
cord-015021-pol2qm74	2520	23	shift	shift	NN
cord-015021-pol2qm74	2520	24	assays	assay	NNS
cord-015021-pol2qm74	2520	25	.	.	.
cord-015021-pol2qm74	2521	1	IRF	IRF	NNP
cord-015021-pol2qm74	2521	2	activity	activity	NN
cord-015021-pol2qm74	2521	3	was	be	VBD
cord-015021-pol2qm74	2521	4	much	much	RB
cord-015021-pol2qm74	2521	5	more	more	RBR
cord-015021-pol2qm74	2521	6	increased	increase	VBN
cord-015021-pol2qm74	2521	7	in	in	IN
cord-015021-pol2qm74	2521	8	cellular	cellular	JJ
cord-015021-pol2qm74	2521	9	extracts	extract	NNS
cord-015021-pol2qm74	2521	10	from	from	IN
cord-015021-pol2qm74	2521	11	murine	murine	JJ
cord-015021-pol2qm74	2521	12	macrophages	macrophage	NNS
cord-015021-pol2qm74	2521	13	(	(	-LRB-
cord-015021-pol2qm74	2521	14	J774	J774	NNS
cord-015021-pol2qm74	2521	15	)	)	-RRB-
cord-015021-pol2qm74	2521	16	where	where	WRB
cord-015021-pol2qm74	2521	17	a	a	DT
cord-015021-pol2qm74	2521	18	cytokine	cytokine	NN
cord-015021-pol2qm74	2521	19	inducible	inducible	JJ
cord-015021-pol2qm74	2521	20	form	form	NN
cord-015021-pol2qm74	2521	21	of	of	IN
cord-015021-pol2qm74	2521	22	NOS	NOS	NNP
cord-015021-pol2qm74	2521	23	has	have	VBZ
cord-015021-pol2qm74	2521	24	been	be	VBN
cord-015021-pol2qm74	2521	25	characterized	characterize	VBN
cord-015021-pol2qm74	2521	26	earlier	early	RBR
cord-015021-pol2qm74	2521	27	as	as	IN
cord-015021-pol2qm74	2521	28	compared	compare	VBN
cord-015021-pol2qm74	2521	29	with	with	IN
cord-015021-pol2qm74	2521	30	IRF	IRF	NNP
cord-015021-pol2qm74	2521	31	activity	activity	NN
cord-015021-pol2qm74	2521	32	in	in	IN
cord-015021-pol2qm74	2521	33	K562	k562	CD
cord-015021-pol2qm74	2521	34	cells	cell	NNS
cord-015021-pol2qm74	2521	35	,	,	,
cord-015021-pol2qm74	2521	36	where	where	WRB
cord-015021-pol2qm74	2521	37	NOS	NOS	NNP
cord-015021-pol2qm74	2521	38	was	be	VBD
cord-015021-pol2qm74	2521	39	stimulated	stimulate	VBN
cord-015021-pol2qm74	2521	40	by	by	IN
cord-015021-pol2qm74	2521	41	increasing	increase	VBG
cord-015021-pol2qm74	2521	42	the	the	DT
cord-015021-pol2qm74	2521	43	availability	availability	NN
cord-015021-pol2qm74	2521	44	of	of	IN
cord-015021-pol2qm74	2521	45	the	the	DT
cord-015021-pol2qm74	2521	46	essential	essential	JJ
cord-015021-pol2qm74	2521	47	NOS	NOS	NNP
cord-015021-pol2qm74	2521	48	cofactor	cofactor	NN
cord-015021-pol2qm74	2521	49	5,6,7,8-tetrahydrobiopterin	5,6,7,8-tetrahydrobiopterin	CD
cord-015021-pol2qm74	2521	50	.	.	.
cord-015021-pol2qm74	2522	1	We	-PRON-	PRP
cord-015021-pol2qm74	2522	2	then	then	RB
cord-015021-pol2qm74	2522	3	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	2522	4	that	that	IN
cord-015021-pol2qm74	2522	5	activation	activation	NN
cord-015021-pol2qm74	2522	6	of	of	IN
cord-015021-pol2qm74	2522	7	IRF	IRF	NNP
cord-015021-pol2qm74	2522	8	by	by	IN
cord-015021-pol2qm74	2522	9	nitric	nitric	NN
cord-015021-pol2qm74	2522	10	oxide	oxide	NN
cord-015021-pol2qm74	2522	11	is	be	VBZ
cord-015021-pol2qm74	2522	12	accompanied	accompany	VBN
cord-015021-pol2qm74	2522	13	by	by	IN
cord-015021-pol2qm74	2522	14	alterations	alteration	NNS
cord-015021-pol2qm74	2522	15	in	in	IN
cord-015021-pol2qm74	2522	16	ferritin	ferritin	NN
cord-015021-pol2qm74	2522	17	translation	translation	NN
cord-015021-pol2qm74	2522	18	as	as	IN
cord-015021-pol2qm74	2522	19	checked	check	VBN
cord-015021-pol2qm74	2522	20	by	by	IN
cord-015021-pol2qm74	2522	21	metabolic	metabolic	JJ
cord-015021-pol2qm74	2522	22	labeling	labeling	NN
cord-015021-pol2qm74	2522	23	and	and	CC
cord-015021-pol2qm74	2522	24	immunoprecipitation	immunoprecipitation	NN
cord-015021-pol2qm74	2522	25	.	.	.
cord-015021-pol2qm74	2523	1	These	these	DT
cord-015021-pol2qm74	2523	2	results	result	NNS
cord-015021-pol2qm74	2523	3	suggest	suggest	VBP
cord-015021-pol2qm74	2523	4	a	a	DT
cord-015021-pol2qm74	2523	5	reasonable	reasonable	JJ
cord-015021-pol2qm74	2523	6	mechanism	mechanism	NN
cord-015021-pol2qm74	2523	7	for	for	IN
cord-015021-pol2qm74	2523	8	the	the	DT
cord-015021-pol2qm74	2523	9	regulation	regulation	NN
cord-015021-pol2qm74	2523	10	of	of	IN
cord-015021-pol2qm74	2523	11	iron	iron	NN
cord-015021-pol2qm74	2523	12	disturbances	disturbance	NNS
cord-015021-pol2qm74	2523	13	under	under	IN
cord-015021-pol2qm74	2523	14	chronic	chronic	JJ
cord-015021-pol2qm74	2523	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2523	16	disorders	disorder	NNS
cord-015021-pol2qm74	2523	17	,	,	,
cord-015021-pol2qm74	2523	18	characterized	characterize	VBN
cord-015021-pol2qm74	2523	19	by	by	IN
cord-015021-pol2qm74	2523	20	increased	increase	VBN
cord-015021-pol2qm74	2523	21	concentration	concentration	NN
cord-015021-pol2qm74	2523	22	of	of	IN
cord-015021-pol2qm74	2523	23	immune	immune	JJ
cord-015021-pol2qm74	2523	24	activation	activation	NN
cord-015021-pol2qm74	2523	25	parameters	parameter	NNS
cord-015021-pol2qm74	2523	26	like	like	IN
cord-015021-pol2qm74	2523	27	IFN-5or	IFN-5or	NNP
cord-015021-pol2qm74	2523	28	neopterin	neopterin	NN
cord-015021-pol2qm74	2523	29	and	and	CC
cord-015021-pol2qm74	2523	30	low	low	JJ
cord-015021-pol2qm74	2523	31	serum	serum	NN
cord-015021-pol2qm74	2523	32	iron	iron	NN
cord-015021-pol2qm74	2523	33	and	and	CC
cord-015021-pol2qm74	2523	34	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	2523	35	concentrations	concentration	NNS
cord-015021-pol2qm74	2523	36	.	.	.
cord-015021-pol2qm74	2524	1	Taken	take	VBN
cord-015021-pol2qm74	2524	2	Nitric	Nitric	NNP
cord-015021-pol2qm74	2524	3	oxide	oxide	NN
cord-015021-pol2qm74	2524	4	,	,	,
cord-015021-pol2qm74	2524	5	NO	no	UH
cord-015021-pol2qm74	2524	6	,	,	,
cord-015021-pol2qm74	2524	7	the	the	DT
cord-015021-pol2qm74	2524	8	putative	putative	JJ
cord-015021-pol2qm74	2524	9	endothelial	endothelial	JJ
cord-015021-pol2qm74	2524	10	derived	derive	VBN
cord-015021-pol2qm74	2524	11	relaxant	relaxant	NN
cord-015021-pol2qm74	2524	12	factor	factor	NN
cord-015021-pol2qm74	2524	13	,	,	,
cord-015021-pol2qm74	2524	14	EDRF	EDRF	NNP
cord-015021-pol2qm74	2524	15	,	,	,
cord-015021-pol2qm74	2524	16	has	have	VBZ
cord-015021-pol2qm74	2524	17	been	be	VBN
cord-015021-pol2qm74	2524	18	shown	show	VBN
cord-015021-pol2qm74	2524	19	to	to	TO
cord-015021-pol2qm74	2524	20	be	be	VB
cord-015021-pol2qm74	2524	21	a	a	DT
cord-015021-pol2qm74	2524	22	potent	potent	JJ
cord-015021-pol2qm74	2524	23	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2524	24	ofplatelet	ofplatelet	NN
cord-015021-pol2qm74	2524	25	aggregation	aggregation	NN
cord-015021-pol2qm74	2524	26	in	in	IN
cord-015021-pol2qm74	2524	27	vitro	vitro	FW
cord-015021-pol2qm74	2524	28	.	.	.
cord-015021-pol2qm74	2525	1	In	in	IN
cord-015021-pol2qm74	2525	2	vivo	vivo	NN
cord-015021-pol2qm74	2525	3	evidence	evidence	NN
cord-015021-pol2qm74	2525	4	however	however	RB
cord-015021-pol2qm74	2525	5	,	,	,
cord-015021-pol2qm74	2525	6	is	be	VBZ
cord-015021-pol2qm74	2525	7	scarce	scarce	JJ
cord-015021-pol2qm74	2525	8	.	.	.
cord-015021-pol2qm74	2526	1	Accumulation	accumulation	NN
cord-015021-pol2qm74	2526	2	of	of	IN
cord-015021-pol2qm74	2526	3	platelets	platelet	NNS
cord-015021-pol2qm74	2526	4	in	in	IN
cord-015021-pol2qm74	2526	5	the	the	DT
cord-015021-pol2qm74	2526	6	lungs	lung	NNS
cord-015021-pol2qm74	2526	7	has	have	VBZ
cord-015021-pol2qm74	2526	8	been	be	VBN
cord-015021-pol2qm74	2526	9	shown	show	VBN
cord-015021-pol2qm74	2526	10	to	to	TO
cord-015021-pol2qm74	2526	11	occur	occur	VB
cord-015021-pol2qm74	2526	12	during	during	IN
cord-015021-pol2qm74	2526	13	extracorporeal	extracorporeal	JJ
cord-015021-pol2qm74	2526	14	circulation	circulation	NN
cord-015021-pol2qm74	2526	15	.	.	.
cord-015021-pol2qm74	2527	1	The	the	DT
cord-015021-pol2qm74	2527	2	aim	aim	NN
cord-015021-pol2qm74	2527	3	of	of	IN
cord-015021-pol2qm74	2527	4	the	the	DT
cord-015021-pol2qm74	2527	5	present	present	JJ
cord-015021-pol2qm74	2527	6	study	study	NN
cord-015021-pol2qm74	2527	7	was	be	VBD
cord-015021-pol2qm74	2527	8	to	to	TO
cord-015021-pol2qm74	2527	9	investigate	investigate	VB
cord-015021-pol2qm74	2527	10	the	the	DT
cord-015021-pol2qm74	2527	11	effect	effect	NN
cord-015021-pol2qm74	2527	12	of	of	IN
cord-015021-pol2qm74	2527	13	inhaled	inhale	VBN
cord-015021-pol2qm74	2527	14	NO	no	RB
cord-015021-pol2qm74	2527	15	on	on	IN
cord-015021-pol2qm74	2527	16	this	this	DT
cord-015021-pol2qm74	2527	17	reaction	reaction	NN
cord-015021-pol2qm74	2527	18	.	.	.
cord-015021-pol2qm74	2528	1	Materials	material	NNS
cord-015021-pol2qm74	2528	2	and	and	CC
cord-015021-pol2qm74	2528	3	methods	method	NNS
cord-015021-pol2qm74	2528	4	:	:	:
cord-015021-pol2qm74	2528	5	The	the	DT
cord-015021-pol2qm74	2528	6	animals	animal	NNS
cord-015021-pol2qm74	2528	7	were	be	VBD
cord-015021-pol2qm74	2528	8	divided	divide	VBN
cord-015021-pol2qm74	2528	9	into	into	IN
cord-015021-pol2qm74	2528	10	two	two	CD
cord-015021-pol2qm74	2528	11	groups	group	NNS
cord-015021-pol2qm74	2528	12	,	,	,
cord-015021-pol2qm74	2528	13	each	each	DT
cord-015021-pol2qm74	2528	14	consisting	consist	VBG
cord-015021-pol2qm74	2528	15	of	of	IN
cord-015021-pol2qm74	2528	16	7	7	CD
cord-015021-pol2qm74	2528	17	pigs	pig	NNS
cord-015021-pol2qm74	2528	18	.	.	.
cord-015021-pol2qm74	2529	1	Platelets	platelet	NNS
cord-015021-pol2qm74	2529	2	were	be	VBD
cord-015021-pol2qm74	2529	3	selectively	selectively	RB
cord-015021-pol2qm74	2529	4	labelled	label	VBN
cord-015021-pol2qm74	2529	5	with	with	IN
cord-015021-pol2qm74	2529	6	lUln	luln	NN
cord-015021-pol2qm74	2529	7	-	-	HYPH
cord-015021-pol2qm74	2529	8	oxine	oxine	NN
cord-015021-pol2qm74	2529	9	.	.	.
cord-015021-pol2qm74	2530	1	Dialysis	dialysis	NN
cord-015021-pol2qm74	2530	2	was	be	VBD
cord-015021-pol2qm74	2530	3	instituted	institute	VBN
cord-015021-pol2qm74	2530	4	via	via	IN
cord-015021-pol2qm74	2530	5	catheters	catheter	NNS
cord-015021-pol2qm74	2530	6	in	in	IN
cord-015021-pol2qm74	2530	7	the	the	DT
cord-015021-pol2qm74	2530	8	femoral	femoral	JJ
cord-015021-pol2qm74	2530	9	vessels	vessel	NNS
cord-015021-pol2qm74	2530	10	.	.	.
cord-015021-pol2qm74	2531	1	In	in	IN
cord-015021-pol2qm74	2531	2	group	group	NN
cord-015021-pol2qm74	2531	3	1	1	CD
cord-015021-pol2qm74	2531	4	,	,	,
cord-015021-pol2qm74	2531	5	NO	no	UH
cord-015021-pol2qm74	2531	6	,	,	,
cord-015021-pol2qm74	2531	7	50	50	CD
cord-015021-pol2qm74	2531	8	ppm	ppm	NN
cord-015021-pol2qm74	2531	9	,	,	,
cord-015021-pol2qm74	2531	10	was	be	VBD
cord-015021-pol2qm74	2531	11	added	add	VBN
cord-015021-pol2qm74	2531	12	to	to	IN
cord-015021-pol2qm74	2531	13	the	the	DT
cord-015021-pol2qm74	2531	14	inhaled	inhale	VBN
cord-015021-pol2qm74	2531	15	gas	gas	NN
cord-015021-pol2qm74	2531	16	from	from	IN
cord-015021-pol2qm74	2531	17	the	the	DT
cord-015021-pol2qm74	2531	18	start	start	NN
cord-015021-pol2qm74	2531	19	of	of	IN
cord-015021-pol2qm74	2531	20	dialysis	dialysis	NN
cord-015021-pol2qm74	2531	21	.	.	.
cord-015021-pol2qm74	2532	1	In	in	IN
cord-015021-pol2qm74	2532	2	group	group	NN
cord-015021-pol2qm74	2532	3	2	2	CD
cord-015021-pol2qm74	2532	4	NO	no	NN
cord-015021-pol2qm74	2532	5	was	be	VBD
cord-015021-pol2qm74	2532	6	not	not	RB
cord-015021-pol2qm74	2532	7	given	give	VBN
cord-015021-pol2qm74	2532	8	.	.	.
cord-015021-pol2qm74	2533	1	The	the	DT
cord-015021-pol2qm74	2533	2	activity	activity	NN
cord-015021-pol2qm74	2533	3	over	over	IN
cord-015021-pol2qm74	2533	4	the	the	DT
cord-015021-pol2qm74	2533	5	lungs	lung	NNS
cord-015021-pol2qm74	2533	6	was	be	VBD
cord-015021-pol2qm74	2533	7	followed	follow	VBN
cord-015021-pol2qm74	2533	8	dynamically	dynamically	RB
cord-015021-pol2qm74	2533	9	with	with	IN
cord-015021-pol2qm74	2533	10	a	a	DT
cord-015021-pol2qm74	2533	11	gamma	gamma	JJ
cord-015021-pol2qm74	2533	12	camera	camera	NN
cord-015021-pol2qm74	2533	13	.	.	.
cord-015021-pol2qm74	2534	1	Central	central	JJ
cord-015021-pol2qm74	2534	2	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	2534	3	was	be	VBD
cord-015021-pol2qm74	2534	4	monitored	monitor	VBN
cord-015021-pol2qm74	2534	5	via	via	IN
cord-015021-pol2qm74	2534	6	a	a	DT
cord-015021-pol2qm74	2534	7	Swan	Swan	NNP
cord-015021-pol2qm74	2534	8	-Ganz	-Ganz	NNP
cord-015021-pol2qm74	2534	9	catheter	catheter	NN
cord-015021-pol2qm74	2534	10	.	.	.
cord-015021-pol2qm74	2535	1	Results	result	NNS
cord-015021-pol2qm74	2535	2	:	:	:
cord-015021-pol2qm74	2536	1	The	the	DT
cord-015021-pol2qm74	2536	2	activity	activity	NN
cord-015021-pol2qm74	2536	3	was	be	VBD
cord-015021-pol2qm74	2536	4	significantly	significantly	RB
cord-015021-pol2qm74	2536	5	lower	low	JJR
cord-015021-pol2qm74	2536	6	in	in	IN
cord-015021-pol2qm74	2536	7	group	group	NN
cord-015021-pol2qm74	2536	8	1	1	CD
cord-015021-pol2qm74	2536	9	,	,	,
cord-015021-pol2qm74	2536	10	from	from	IN
cord-015021-pol2qm74	2536	11	2	2	CD
cord-015021-pol2qm74	2536	12	minutes	minute	NNS
cord-015021-pol2qm74	2536	13	after	after	IN
cord-015021-pol2qm74	2536	14	start	start	NN
cord-015021-pol2qm74	2536	15	of	of	IN
cord-015021-pol2qm74	2536	16	dialysis	dialysis	NN
cord-015021-pol2qm74	2536	17	and	and	CC
cord-015021-pol2qm74	2536	18	onwards	onwards	RB
cord-015021-pol2qm74	2536	19	,	,	,
cord-015021-pol2qm74	2536	20	indicating	indicate	VBG
cord-015021-pol2qm74	2536	21	diminished	diminish	VBN
cord-015021-pol2qm74	2536	22	accumulation	accumulation	NN
cord-015021-pol2qm74	2536	23	of	of	IN
cord-015021-pol2qm74	2536	24	platelets	platelet	NNS
cord-015021-pol2qm74	2536	25	in	in	IN
cord-015021-pol2qm74	2536	26	the	the	DT
cord-015021-pol2qm74	2536	27	lungs	lung	NNS
cord-015021-pol2qm74	2536	28	.	.	.
cord-015021-pol2qm74	2537	1	Parallel	parallel	JJ
cord-015021-pol2qm74	2537	2	to	to	IN
cord-015021-pol2qm74	2537	3	this	this	DT
cord-015021-pol2qm74	2537	4	the	the	DT
cord-015021-pol2qm74	2537	5	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	2537	6	response	response	NN
cord-015021-pol2qm74	2537	7	in	in	IN
cord-015021-pol2qm74	2537	8	terms	term	NNS
cord-015021-pol2qm74	2537	9	of	of	IN
cord-015021-pol2qm74	2537	10	increased	increase	VBN
cord-015021-pol2qm74	2537	11	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2537	12	artery	artery	NN
cord-015021-pol2qm74	2537	13	pressure	pressure	NN
cord-015021-pol2qm74	2537	14	and	and	CC
cord-015021-pol2qm74	2537	15	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2537	16	vascular	vascular	JJ
cord-015021-pol2qm74	2537	17	resistance	resistance	NN
cord-015021-pol2qm74	2537	18	was	be	VBD
cord-015021-pol2qm74	2537	19	blunted	blunt	VBN
cord-015021-pol2qm74	2537	20	in	in	IN
cord-015021-pol2qm74	2537	21	this	this	DT
cord-015021-pol2qm74	2537	22	group	group	NN
cord-015021-pol2qm74	2537	23	Conclusion	conclusion	NN
cord-015021-pol2qm74	2537	24	:	:	:
cord-015021-pol2qm74	2537	25	Inhaled	inhale	VBN
cord-015021-pol2qm74	2537	26	NO	no	RB
cord-015021-pol2qm74	2537	27	in	in	IN
cord-015021-pol2qm74	2537	28	this	this	DT
cord-015021-pol2qm74	2537	29	model	model	NN
cord-015021-pol2qm74	2537	30	seems	seem	VBZ
cord-015021-pol2qm74	2537	31	to	to	TO
cord-015021-pol2qm74	2537	32	affect	affect	VB
cord-015021-pol2qm74	2537	33	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2537	34	platelet	platelet	NN
cord-015021-pol2qm74	2537	35	sequestration	sequestration	NN
cord-015021-pol2qm74	2537	36	.	.	.
cord-015021-pol2qm74	2538	1	An	an	DT
cord-015021-pol2qm74	2538	2	associated	associate	VBN
cord-015021-pol2qm74	2538	3	attenuation	attenuation	NN
cord-015021-pol2qm74	2538	4	of	of	IN
cord-015021-pol2qm74	2538	5	the	the	DT
cord-015021-pol2qm74	2538	6	changes	change	NNS
cord-015021-pol2qm74	2538	7	in	in	IN
cord-015021-pol2qm74	2538	8	central	central	JJ
cord-015021-pol2qm74	2538	9	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	2538	10	was	be	VBD
cord-015021-pol2qm74	2538	11	also	also	RB
cord-015021-pol2qm74	2538	12	seen	see	VBN
cord-015021-pol2qm74	2538	13	.	.	.
cord-015021-pol2qm74	2539	1	Previous	previous	JJ
cord-015021-pol2qm74	2539	2	studies	study	NNS
cord-015021-pol2qm74	2539	3	from	from	IN
cord-015021-pol2qm74	2539	4	our	-PRON-	PRP$
cord-015021-pol2qm74	2539	5	laboratory	laboratory	NN
cord-015021-pol2qm74	2539	6	have	have	VBP
cord-015021-pol2qm74	2539	7	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2539	8	that	that	IN
cord-015021-pol2qm74	2539	9	vascular	vascular	JJ
cord-015021-pol2qm74	2539	10	contractility	contractility	NN
cord-015021-pol2qm74	2539	11	decreased	decrease	VBD
cord-015021-pol2qm74	2539	12	in	in	IN
cord-015021-pol2qm74	2539	13	endothelium	endothelium	NN
cord-015021-pol2qm74	2539	14	-	-	HYPH
cord-015021-pol2qm74	2539	15	intact	intact	JJ
cord-015021-pol2qm74	2539	16	blood	blood	NN
cord-015021-pol2qm74	2539	17	vessel	vessel	NN
cord-015021-pol2qm74	2539	18	rings	ring	VBZ
cord-015021-pol2qm74	2539	19	in	in	IN
cord-015021-pol2qm74	2539	20	early	early	JJ
cord-015021-pol2qm74	2539	21	and	and	CC
cord-015021-pol2qm74	2539	22	late	late	JJ
cord-015021-pol2qm74	2539	23	stages	stage	NNS
cord-015021-pol2qm74	2539	24	of	of	IN
cord-015021-pol2qm74	2539	25	sepsis	sepsis	NN
cord-015021-pol2qm74	2539	26	.	.	.
cord-015021-pol2qm74	2540	1	Although	although	IN
cord-015021-pol2qm74	2540	2	endothelium	endothelium	NN
cord-015021-pol2qm74	2540	3	removal	removal	NN
cord-015021-pol2qm74	2540	4	in	in	IN
cord-015021-pol2qm74	2540	5	early	early	JJ
cord-015021-pol2qm74	2540	6	sepsis	sepsis	NN
cord-015021-pol2qm74	2540	7	restored	restore	VBD
cord-015021-pol2qm74	2540	8	vascular	vascular	JJ
cord-015021-pol2qm74	2540	9	contraction	contraction	NN
cord-015021-pol2qm74	2540	10	,	,	,
cord-015021-pol2qm74	2540	11	the	the	DT
cord-015021-pol2qm74	2540	12	depressed	depressed	JJ
cord-015021-pol2qm74	2540	13	smooth	smooth	JJ
cord-015021-pol2qm74	2540	14	muscle	muscle	NN
cord-015021-pol2qm74	2540	15	contractility	contractility	NN
cord-015021-pol2qm74	2540	16	observed	observe	VBN
cord-015021-pol2qm74	2540	17	in	in	IN
cord-015021-pol2qm74	2540	18	late	late	JJ
cord-015021-pol2qm74	2540	19	sepsis	sepsis	NN
cord-015021-pol2qm74	2540	20	was	be	VBD
cord-015021-pol2qm74	2540	21	not	not	RB
cord-015021-pol2qm74	2540	22	restored	restore	VBN
cord-015021-pol2qm74	2540	23	by	by	IN
cord-015021-pol2qm74	2540	24	endothelium	endothelium	NN
cord-015021-pol2qm74	2540	25	removal	removal	NN
cord-015021-pol2qm74	2540	26	.	.	.
cord-015021-pol2qm74	2541	1	This	this	DT
cord-015021-pol2qm74	2541	2	indicates	indicate	VBZ
cord-015021-pol2qm74	2541	3	that	that	IN
cord-015021-pol2qm74	2541	4	impairment	impairment	NN
cord-015021-pol2qm74	2541	5	of	of	IN
cord-015021-pol2qm74	2541	6	smooth	smooth	JJ
cord-015021-pol2qm74	2541	7	muscleper	muscleper	NN
cord-015021-pol2qm74	2541	8	se	se	FW
cord-015021-pol2qm74	2541	9	may	may	MD
cord-015021-pol2qm74	2541	10	be	be	VB
cord-015021-pol2qm74	2541	11	responsible	responsible	JJ
cord-015021-pol2qm74	2541	12	for	for	IN
cord-015021-pol2qm74	2541	13	such	such	JJ
cord-015021-pol2qm74	2541	14	dysfunction	dysfunction	NN
cord-015021-pol2qm74	2541	15	in	in	IN
cord-015021-pol2qm74	2541	16	late	late	JJ
cord-015021-pol2qm74	2541	17	sepsis	sepsis	NN
cord-015021-pol2qm74	2541	18	.	.	.
cord-015021-pol2qm74	2542	1	The	the	DT
cord-015021-pol2qm74	2542	2	aim	aim	NN
cord-015021-pol2qm74	2542	3	of	of	IN
cord-015021-pol2qm74	2542	4	this	this	DT
cord-015021-pol2qm74	2542	5	study	study	NN
cord-015021-pol2qm74	2542	6	,	,	,
cord-015021-pol2qm74	2542	7	therefore	therefore	RB
cord-015021-pol2qm74	2542	8	,	,	,
cord-015021-pol2qm74	2542	9	was	be	VBD
cord-015021-pol2qm74	2542	10	to	to	TO
cord-015021-pol2qm74	2542	11	determine	determine	VB
cord-015021-pol2qm74	2542	12	whether	whether	IN
cord-015021-pol2qm74	2542	13	or	or	CC
cord-015021-pol2qm74	2542	14	not	not	RB
cord-015021-pol2qm74	2542	15	smooth	smooth	JJ
cord-015021-pol2qm74	2542	16	muscle	muscle	NN
cord-015021-pol2qm74	2542	17	-	-	HYPH
cord-015021-pol2qm74	2542	18	derived	derive	VBN
cord-015021-pol2qm74	2542	19	nitric	nitric	NN
cord-015021-pol2qm74	2542	20	oxide	oxide	NN
cord-015021-pol2qm74	2542	21	(	(	-LRB-
cord-015021-pol2qm74	2542	22	NO	no	UH
cord-015021-pol2qm74	2542	23	)	)	-RRB-
cord-015021-pol2qm74	2542	24	plays	play	VBZ
cord-015021-pol2qm74	2542	25	a	a	DT
cord-015021-pol2qm74	2542	26	role	role	NN
cord-015021-pol2qm74	2542	27	in	in	IN
cord-015021-pol2qm74	2542	28	producing	produce	VBG
cord-015021-pol2qm74	2542	29	vascular	vascular	JJ
cord-015021-pol2qm74	2542	30	smooth	smooth	JJ
cord-015021-pol2qm74	2542	31	muscle	muscle	NN
cord-015021-pol2qm74	2542	32	dysfunction	dysfunction	NN
cord-015021-pol2qm74	2542	33	during	during	IN
cord-015021-pol2qm74	2542	34	late	late	JJ
cord-015021-pol2qm74	2542	35	stages	stage	NNS
cord-015021-pol2qm74	2542	36	of	of	IN
cord-015021-pol2qm74	2542	37	sepsis	sepsis	NN
cord-015021-pol2qm74	2542	38	.	.	.
cord-015021-pol2qm74	2543	1	To	to	TO
cord-015021-pol2qm74	2543	2	study	study	VB
cord-015021-pol2qm74	2543	3	this	this	DT
cord-015021-pol2qm74	2543	4	,	,	,
cord-015021-pol2qm74	2543	5	rats	rat	NNS
cord-015021-pol2qm74	2543	6	(	(	-LRB-
cord-015021-pol2qm74	2543	7	250	250	CD
cord-015021-pol2qm74	2543	8	-	-	SYM
cord-015021-pol2qm74	2543	9	300	300	CD
cord-015021-pol2qm74	2543	10	g	g	NN
cord-015021-pol2qm74	2543	11	,	,	,
cord-015021-pol2qm74	2543	12	n=4	n=4	JJ
cord-015021-pol2qm74	2543	13	-	-	HYPH
cord-015021-pol2qm74	2543	14	5	5	CD
cord-015021-pol2qm74	2543	15	/	/	SYM
cord-015021-pol2qm74	2543	16	group	group	NN
cord-015021-pol2qm74	2543	17	)	)	-RRB-
cord-015021-pol2qm74	2543	18	were	be	VBD
cord-015021-pol2qm74	2543	19	subjected	subject	VBN
cord-015021-pol2qm74	2543	20	to	to	IN
cord-015021-pol2qm74	2543	21	sepsis	sepsis	NN
cord-015021-pol2qm74	2543	22	by	by	IN
cord-015021-pol2qm74	2543	23	cecal	cecal	JJ
cord-015021-pol2qm74	2543	24	ligation	ligation	NN
cord-015021-pol2qm74	2543	25	and	and	CC
cord-015021-pol2qm74	2543	26	puncture	puncture	NN
cord-015021-pol2qm74	2543	27	(	(	-LRB-
cord-015021-pol2qm74	2543	28	CLP	CLP	NNP
cord-015021-pol2qm74	2543	29	)	)	-RRB-
cord-015021-pol2qm74	2543	30	.	.	.
cord-015021-pol2qm74	2544	1	Septic	septic	JJ
cord-015021-pol2qm74	2544	2	and	and	CC
cord-015021-pol2qm74	2544	3	shamoperated	shamoperated	JJ
cord-015021-pol2qm74	2544	4	rats	rat	NNS
cord-015021-pol2qm74	2544	5	then	then	RB
cord-015021-pol2qm74	2544	6	received	receive	VBD
cord-015021-pol2qm74	2544	7	3	3	CD
cord-015021-pol2qm74	2544	8	rrd/100	rrd/100	NNS
cord-015021-pol2qm74	2544	9	g	g	NNP
cord-015021-pol2qm74	2544	10	BW	BW	NNP
cord-015021-pol2qm74	2544	11	normal	normal	JJ
cord-015021-pol2qm74	2544	12	saline	saline	NN
cord-015021-pol2qm74	2544	13	.	.	.
cord-015021-pol2qm74	2545	1	The	the	DT
cord-015021-pol2qm74	2545	2	animals	animal	NNS
cord-015021-pol2qm74	2545	3	were	be	VBD
cord-015021-pol2qm74	2545	4	killed	kill	VBN
cord-015021-pol2qm74	2545	5	at	at	IN
cord-015021-pol2qm74	2545	6	10	10	CD
cord-015021-pol2qm74	2545	7	,	,	,
cord-015021-pol2qm74	2545	8	20	20	CD
cord-015021-pol2qm74	2545	9	,	,	,
cord-015021-pol2qm74	2545	10	or	or	CC
cord-015021-pol2qm74	2545	11	35	35	CD
cord-015021-pol2qm74	2545	12	h	h	NN
cord-015021-pol2qm74	2545	13	post	post	NN
cord-015021-pol2qm74	2545	14	-	-	JJ
cord-015021-pol2qm74	2545	15	CLP	CLP	NNP
cord-015021-pol2qm74	2545	16	(	(	-LRB-
cord-015021-pol2qm74	2545	17	10	10	CD
cord-015021-pol2qm74	2545	18	h	h	NN
cord-015021-pol2qm74	2545	19	post	post	NN
cord-015021-pol2qm74	2545	20	-	-	JJ
cord-015021-pol2qm74	2545	21	CLP	clp	NN
cord-015021-pol2qm74	2545	22	=	=	SYM
cord-015021-pol2qm74	2545	23	early	early	JJ
cord-015021-pol2qm74	2545	24	sepsis	sepsis	NN
cord-015021-pol2qm74	2545	25	;	;	:
cord-015021-pol2qm74	2545	26	20	20	CD
cord-015021-pol2qm74	2545	27	-	-	SYM
cord-015021-pol2qm74	2545	28	35	35	CD
cord-015021-pol2qm74	2545	29	h	h	NN
cord-015021-pol2qm74	2545	30	post	post	NN
cord-015021-pol2qm74	2545	31	-	-	JJ
cord-015021-pol2qm74	2545	32	CLP	clp	JJ
cord-015021-pol2qm74	2545	33	=	=	SYM
cord-015021-pol2qm74	2545	34	late	late	JJ
cord-015021-pol2qm74	2545	35	sepsis	sepsis	NN
cord-015021-pol2qm74	2545	36	)	)	-RRB-
cord-015021-pol2qm74	2545	37	,	,	,
cord-015021-pol2qm74	2545	38	and	and	CC
cord-015021-pol2qm74	2545	39	thoracic	thoracic	JJ
cord-015021-pol2qm74	2545	40	aortic	aortic	JJ
cord-015021-pol2qm74	2545	41	rings	ring	NNS
cord-015021-pol2qm74	2545	42	were	be	VBD
cord-015021-pol2qm74	2545	43	prepared	prepare	VBN
cord-015021-pol2qm74	2545	44	for	for	IN
cord-015021-pol2qm74	2545	45	contraction	contraction	NN
cord-015021-pol2qm74	2545	46	studies	study	NNS
cord-015021-pol2qm74	2545	47	using	use	VBG
cord-015021-pol2qm74	2545	48	organ	organ	NN
cord-015021-pol2qm74	2545	49	chambers	chamber	NNS
cord-015021-pol2qm74	2545	50	.	.	.
cord-015021-pol2qm74	2546	1	The	the	DT
cord-015021-pol2qm74	2546	2	complete	complete	JJ
cord-015021-pol2qm74	2546	3	removal	removal	NN
cord-015021-pol2qm74	2546	4	of	of	IN
cord-015021-pol2qm74	2546	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	2546	6	cells	cell	NNS
cord-015021-pol2qm74	2546	7	was	be	VBD
cord-015021-pol2qm74	2546	8	tested	test	VBN
cord-015021-pol2qm74	2546	9	by	by	IN
cord-015021-pol2qm74	2546	10	the	the	DT
cord-015021-pol2qm74	2546	11	absence	absence	NN
cord-015021-pol2qm74	2546	12	of	of	IN
cord-015021-pol2qm74	2546	13	any	any	DT
cord-015021-pol2qm74	2546	14	significant	significant	JJ
cord-015021-pol2qm74	2546	15	acetylcholine	acetylcholine	NN
cord-015021-pol2qm74	2546	16	-	-	HYPH
cord-015021-pol2qm74	2546	17	induced	induce	VBN
cord-015021-pol2qm74	2546	18	vascular	vascular	JJ
cord-015021-pol2qm74	2546	19	relaxation	relaxation	NN
cord-015021-pol2qm74	2546	20	.	.	.
cord-015021-pol2qm74	2547	1	Contractile	Contractile	NNP
cord-015021-pol2qm74	2547	2	responses	response	NNS
cord-015021-pol2qm74	2547	3	to	to	IN
cord-015021-pol2qm74	2547	4	norepinephrine	norepinephrine	NN
cord-015021-pol2qm74	2547	5	(	(	-LRB-
cord-015021-pol2qm74	2547	6	NE	NE	NNP
cord-015021-pol2qm74	2547	7	,	,	,
cord-015021-pol2qm74	2547	8	10	10	CD
cord-015021-pol2qm74	2547	9	9	9	CD
cord-015021-pol2qm74	2547	10	to	to	TO
cord-015021-pol2qm74	2547	11	10	10	CD
cord-015021-pol2qm74	2547	12	-5	-5	NNP
cord-015021-pol2qm74	2547	13	M	M	NNP
cord-015021-pol2qm74	2547	14	)	)	-RRB-
cord-015021-pol2qm74	2547	15	were	be	VBD
cord-015021-pol2qm74	2547	16	determined	determine	VBN
cord-015021-pol2qm74	2547	17	in	in	IN
cord-015021-pol2qm74	2547	18	the	the	DT
cord-015021-pol2qm74	2547	19	aortic	aortic	JJ
cord-015021-pol2qm74	2547	20	rings	ring	NNS
cord-015021-pol2qm74	2547	21	without	without	IN
cord-015021-pol2qm74	2547	22	intact	intact	JJ
cord-015021-pol2qm74	2547	23	endothelium	endothelium	NN
cord-015021-pol2qm74	2547	24	.	.	.
cord-015021-pol2qm74	2548	1	NG	NG	NNP
cord-015021-pol2qm74	2548	2	-	-	HYPH
cord-015021-pol2qm74	2548	3	monomethyl	monomethyl	NNP
cord-015021-pol2qm74	2549	1	-L	-L	:
cord-015021-pol2qm74	2549	2	-	-	HYPH
cord-015021-pol2qm74	2549	3	arginine	arginine	NN
cord-015021-pol2qm74	2550	1	(	(	-LRB-
cord-015021-pol2qm74	2550	2	L	L	NNP
cord-015021-pol2qm74	2550	3	-	-	HYPH
cord-015021-pol2qm74	2550	4	NMMA	NMMA	NNP
cord-015021-pol2qm74	2550	5	,	,	,
cord-015021-pol2qm74	2550	6	300/~M	300/~m	CD
cord-015021-pol2qm74	2550	7	,	,	,
cord-015021-pol2qm74	2550	8	an	an	DT
cord-015021-pol2qm74	2550	9	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2550	10	of	of	IN
cord-015021-pol2qm74	2550	11	NO	no	DT
cord-015021-pol2qm74	2550	12	synthase	synthase	NN
cord-015021-pol2qm74	2550	13	)	)	-RRB-
cord-015021-pol2qm74	2550	14	was	be	VBD
cord-015021-pol2qm74	2550	15	then	then	RB
cord-015021-pol2qm74	2550	16	added	add	VBN
cord-015021-pol2qm74	2550	17	to	to	IN
cord-015021-pol2qm74	2550	18	the	the	DT
cord-015021-pol2qm74	2550	19	organ	organ	NN
cord-015021-pol2qm74	2550	20	chamber	chamber	NN
cord-015021-pol2qm74	2550	21	and	and	CC
cord-015021-pol2qm74	2550	22	NE	NE	NNP
cord-015021-pol2qm74	2550	23	-	-	HYPH
cord-015021-pol2qm74	2550	24	induced	induce	VBN
cord-015021-pol2qm74	2550	25	peak	peak	NN
cord-015021-pol2qm74	2550	26	contraction	contraction	NN
cord-015021-pol2qm74	2550	27	was	be	VBD
cord-015021-pol2qm74	2550	28	determined	determine	VBN
cord-015021-pol2qm74	2550	29	before	before	IN
cord-015021-pol2qm74	2550	30	and	and	CC
cord-015021-pol2qm74	2550	31	after	after	IN
cord-015021-pol2qm74	2550	32	the	the	DT
cord-015021-pol2qm74	2550	33	addition	addition	NN
cord-015021-pol2qm74	2550	34	of	of	IN
cord-015021-pol2qm74	2550	35	L	L	NNP
cord-015021-pol2qm74	2550	36	-	-	HYPH
cord-015021-pol2qm74	2550	37	NMMA	NMMA	NNP
cord-015021-pol2qm74	2550	38	.	.	.
cord-015021-pol2qm74	2551	1	The	the	DT
cord-015021-pol2qm74	2551	2	peak	peak	NN
cord-015021-pol2qm74	2551	3	contraction	contraction	NN
cord-015021-pol2qm74	2551	4	(	(	-LRB-
cord-015021-pol2qm74	2551	5	rag	rag	NN
cord-015021-pol2qm74	2551	6	/	/	SYM
cord-015021-pol2qm74	2551	7	rag	rag	NN
cord-015021-pol2qm74	2551	8	tissue	tissue	NN
cord-015021-pol2qm74	2551	9	,	,	,
cord-015021-pol2qm74	2551	10	mean_+SEM	mean_+SEM	NNP
cord-015021-pol2qm74	2551	11	)	)	-RRB-
cord-015021-pol2qm74	2551	12	is	be	VBZ
cord-015021-pol2qm74	2551	13	shown	show	VBN
cord-015021-pol2qm74	2551	14	below	below	IN
cord-015021-pol2qm74	2551	15	:	:	:
cord-015021-pol2qm74	2551	16	The	the	DT
cord-015021-pol2qm74	2551	17	results	result	NNS
cord-015021-pol2qm74	2551	18	indicate	indicate	VBP
cord-015021-pol2qm74	2551	19	that	that	IN
cord-015021-pol2qm74	2551	20	the	the	DT
cord-015021-pol2qm74	2551	21	addition	addition	NN
cord-015021-pol2qm74	2551	22	of	of	IN
cord-015021-pol2qm74	2551	23	L	L	NNP
cord-015021-pol2qm74	2551	24	-	-	HYPH
cord-015021-pol2qm74	2551	25	NMMA	NMMA	NNP
cord-015021-pol2qm74	2551	26	did	do	VBD
cord-015021-pol2qm74	2551	27	not	not	RB
cord-015021-pol2qm74	2551	28	significantly	significantly	RB
cord-015021-pol2qm74	2551	29	affect	affect	VB
cord-015021-pol2qm74	2551	30	NE	NE	NNP
cord-015021-pol2qm74	2551	31	-	-	HYPH
cord-015021-pol2qm74	2551	32	lnduced	lnduce	VBN
cord-015021-pol2qm74	2551	33	peak	peak	NN
cord-015021-pol2qm74	2551	34	contraction	contraction	NN
cord-015021-pol2qm74	2551	35	in	in	IN
cord-015021-pol2qm74	2551	36	endothelium	endothelium	NN
cord-015021-pol2qm74	2551	37	-	-	HYPH
cord-015021-pol2qm74	2551	38	denuded	denude	VBN
cord-015021-pol2qm74	2551	39	vessel	vessel	NN
cord-015021-pol2qm74	2551	40	rings	ring	NNS
cord-015021-pol2qm74	2551	41	at	at	IN
cord-015021-pol2qm74	2551	42	10	10	CD
cord-015021-pol2qm74	2551	43	and	and	CC
cord-015021-pol2qm74	2551	44	20	20	CD
cord-015021-pol2qm74	2551	45	h	h	NN
cord-015021-pol2qm74	2551	46	after	after	IN
cord-015021-pol2qm74	2551	47	CLP	CLP	NNP
cord-015021-pol2qm74	2551	48	.	.	.
cord-015021-pol2qm74	2552	1	In	in	IN
cord-015021-pol2qm74	2552	2	contrast	contrast	NN
cord-015021-pol2qm74	2552	3	,	,	,
cord-015021-pol2qm74	2552	4	L	L	NNP
cord-015021-pol2qm74	2552	5	-	-	HYPH
cord-015021-pol2qm74	2552	6	NMMA	NMMA	NNP
cord-015021-pol2qm74	2552	7	administration	administration	NN
cord-015021-pol2qm74	2552	8	produces	produce	VBZ
cord-015021-pol2qm74	2552	9	an	an	DT
cord-015021-pol2qm74	2552	10	18	18	CD
cord-015021-pol2qm74	2552	11	%	%	NN
cord-015021-pol2qm74	2552	12	increase	increase	NN
cord-015021-pol2qm74	2552	13	(	(	-LRB-
cord-015021-pol2qm74	2552	14	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	2552	15	)	)	-RRB-
cord-015021-pol2qm74	2552	16	in	in	IN
cord-015021-pol2qm74	2552	17	peak	peak	NN
cord-015021-pol2qm74	2552	18	contraction	contraction	NN
cord-015021-pol2qm74	2552	19	during	during	IN
cord-015021-pol2qm74	2552	20	late	late	JJ
cord-015021-pol2qm74	2552	21	sepsis	sepsis	NN
cord-015021-pol2qm74	2552	22	.	.	.
cord-015021-pol2qm74	2553	1	Therefore	therefore	RB
cord-015021-pol2qm74	2553	2	,	,	,
cord-015021-pol2qm74	2553	3	the	the	DT
cord-015021-pol2qm74	2553	4	vascular	vascular	JJ
cord-015021-pol2qm74	2553	5	smooth	smooth	JJ
cord-015021-pol2qm74	2553	6	muscle	muscle	NN
cord-015021-pol2qm74	2553	7	contractile	contractile	JJ
cord-015021-pol2qm74	2553	8	dysfunction	dysfunction	NN
cord-015021-pol2qm74	2553	9	observed	observe	VBD
cord-015021-pol2qm74	2553	10	at	at	IN
cord-015021-pol2qm74	2553	11	35	35	CD
cord-015021-pol2qm74	2553	12	h	h	NN
cord-015021-pol2qm74	2553	13	post	post	NN
cord-015021-pol2qm74	2553	14	-	-	NN
cord-015021-pol2qm74	2553	15	CLP	CLP	NNP
cord-015021-pol2qm74	2553	16	is	be	VBZ
cord-015021-pol2qm74	2553	17	partially	partially	RB
cord-015021-pol2qm74	2553	18	due	due	JJ
cord-015021-pol2qm74	2553	19	to	to	IN
cord-015021-pol2qm74	2553	20	smooth	smooth	JJ
cord-015021-pol2qm74	2553	21	muscle	muscle	NN
cord-015021-pol2qm74	2553	22	-	-	HYPH
cord-015021-pol2qm74	2553	23	derived	derive	VBN
cord-015021-pol2qm74	2553	24	NO	no	RB
cord-015021-pol2qm74	2553	25	over	over	IN
cord-015021-pol2qm74	2553	26	-	-	HYPH
cord-015021-pol2qm74	2553	27	production	production	NN
cord-015021-pol2qm74	2553	28	.	.	.
cord-015021-pol2qm74	2554	1	Thus	thus	RB
cord-015021-pol2qm74	2554	2	,	,	,
cord-015021-pol2qm74	2554	3	unlike	unlike	IN
cord-015021-pol2qm74	2554	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	2554	5	in	in	IN
cord-015021-pol2qm74	2554	6	which	which	WDT
cord-015021-pol2qm74	2554	7	inducible	inducible	JJ
cord-015021-pol2qm74	2554	8	nitric	nitric	NN
cord-015021-pol2qm74	2554	9	oxide	oxide	NN
cord-015021-pol2qm74	2554	10	synthase	synthase	NN
cord-015021-pol2qm74	2554	11	(	(	-LRB-
cord-015021-pol2qm74	2554	12	iNOS	inos	NN
cord-015021-pol2qm74	2554	13	)	)	-RRB-
cord-015021-pol2qm74	2554	14	is	be	VBZ
cord-015021-pol2qm74	2554	15	observed	observe	VBN
cord-015021-pol2qm74	2554	16	in	in	IN
cord-015021-pol2qm74	2554	17	early	early	JJ
cord-015021-pol2qm74	2554	18	sepsis	sepsis	NN
cord-015021-pol2qm74	2554	19	,	,	,
cord-015021-pol2qm74	2554	20	the	the	DT
cord-015021-pol2qm74	2554	21	iNOS	inos	NN
cord-015021-pol2qm74	2554	22	in	in	IN
cord-015021-pol2qm74	2554	23	vascular	vascular	JJ
cord-015021-pol2qm74	2554	24	smooth	smooth	JJ
cord-015021-pol2qm74	2554	25	muscle	muscle	NN
cord-015021-pol2qm74	2554	26	appears	appear	VBZ
cord-015021-pol2qm74	2554	27	prominent	prominent	JJ
cord-015021-pol2qm74	2554	28	only	only	RB
cord-015021-pol2qm74	2554	29	in	in	IN
cord-015021-pol2qm74	2554	30	the	the	DT
cord-015021-pol2qm74	2554	31	late	late	JJ
cord-015021-pol2qm74	2554	32	stages	stage	NNS
cord-015021-pol2qm74	2554	33	of	of	IN
cord-015021-pol2qm74	2554	34	sepsis	sepsis	NN
cord-015021-pol2qm74	2554	35	.	.	.
cord-015021-pol2qm74	2555	1	In	in	IN
cord-015021-pol2qm74	2555	2	three	three	CD
cord-015021-pol2qm74	2555	3	cases	case	NNS
cord-015021-pol2qm74	2555	4	of	of	IN
cord-015021-pol2qm74	2555	5	human	human	JJ
cord-015021-pol2qm74	2555	6	septic	septic	JJ
cord-015021-pol2qm74	2555	7	shock	shock	NN
cord-015021-pol2qm74	2555	8	in	in	IN
cord-015021-pol2qm74	2555	9	which	which	WDT
cord-015021-pol2qm74	2555	10	NG	NG	NNP
cord-015021-pol2qm74	2555	11	-	-	HYPH
cord-015021-pol2qm74	2555	12	monomethyI	monomethyI	NNP
cord-015021-pol2qm74	2555	13	-	-	HYPH
cord-015021-pol2qm74	2555	14	L	l	NN
cord-015021-pol2qm74	2555	15	-	-	HYPH
cord-015021-pol2qm74	2555	16	Arginine	Arginine	NNP
cord-015021-pol2qm74	2555	17	,	,	,
cord-015021-pol2qm74	2555	18	(	(	-LRB-
cord-015021-pol2qm74	2555	19	L	L	NNP
cord-015021-pol2qm74	2555	20	-	-	HYPH
cord-015021-pol2qm74	2555	21	NMMA	NMMA	NNP
cord-015021-pol2qm74	2555	22	)	)	-RRB-
cord-015021-pol2qm74	2556	1	a	a	DT
cord-015021-pol2qm74	2556	2	nitric	nitric	NN
cord-015021-pol2qm74	2556	3	-	-	HYPH
cord-015021-pol2qm74	2556	4	oxide	oxide	NN
cord-015021-pol2qm74	2556	5	-	-	HYPH
cord-015021-pol2qm74	2556	6	synthase	synthase	NN
cord-015021-pol2qm74	2556	7	-	-	HYPH
cord-015021-pol2qm74	2556	8	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2556	9	was	be	VBD
cord-015021-pol2qm74	2556	10	applied	apply	VBN
cord-015021-pol2qm74	2556	11	,	,	,
cord-015021-pol2qm74	2556	12	we	-PRON-	PRP
cord-015021-pol2qm74	2556	13	isolated	isolate	VBD
cord-015021-pol2qm74	2556	14	three	three	CD
cord-015021-pol2qm74	2556	15	completely	completely	RB
cord-015021-pol2qm74	2556	16	different	different	JJ
cord-015021-pol2qm74	2556	17	types	type	NNS
cord-015021-pol2qm74	2556	18	of	of	IN
cord-015021-pol2qm74	2556	19	pathogens	pathogen	NNS
cord-015021-pol2qm74	2556	20	:	:	:
cord-015021-pol2qm74	2556	21	Candida	Candida	NNP
cord-015021-pol2qm74	2556	22	,	,	,
cord-015021-pol2qm74	2556	23	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	2556	24	aeruginose	aeruginose	NNP
cord-015021-pol2qm74	2556	25	and	and	CC
cord-015021-pol2qm74	2556	26	multiresistant	multiresistant	NN
cord-015021-pol2qm74	2556	27	coagulase	coagulase	NN
cord-015021-pol2qm74	2556	28	-	-	HYPH
cord-015021-pol2qm74	2556	29	negative	negative	JJ
cord-015021-pol2qm74	2556	30	staphylococci	staphylococcus	NNS
cord-015021-pol2qm74	2556	31	.	.	.
cord-015021-pol2qm74	2557	1	This	this	DT
cord-015021-pol2qm74	2557	2	observation	observation	NN
cord-015021-pol2qm74	2557	3	suggests	suggest	VBZ
cord-015021-pol2qm74	2557	4	that	that	IN
cord-015021-pol2qm74	2557	5	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2557	6	alone	alone	RB
cord-015021-pol2qm74	2557	7	is	be	VBZ
cord-015021-pol2qm74	2557	8	not	not	RB
cord-015021-pol2qm74	2557	9	the	the	DT
cord-015021-pol2qm74	2557	10	main	main	JJ
cord-015021-pol2qm74	2557	11	factor	factor	NN
cord-015021-pol2qm74	2557	12	triggering	trigger	VBG
cord-015021-pol2qm74	2557	13	hypotension	hypotension	NN
cord-015021-pol2qm74	2557	14	in	in	IN
cord-015021-pol2qm74	2557	15	septic	septic	JJ
cord-015021-pol2qm74	2557	16	shock	shock	NN
cord-015021-pol2qm74	2557	17	by	by	IN
cord-015021-pol2qm74	2557	18	the	the	DT
cord-015021-pol2qm74	2557	19	nitric	nitric	NN
cord-015021-pol2qm74	2557	20	oxide	oxide	NN
cord-015021-pol2qm74	2557	21	pathway	pathway	NN
cord-015021-pol2qm74	2557	22	.	.	.
cord-015021-pol2qm74	2558	1	In	in	IN
cord-015021-pol2qm74	2558	2	a	a	DT
cord-015021-pol2qm74	2558	3	68-years	68-years	CD
cord-015021-pol2qm74	2558	4	-	-	HYPH
cord-015021-pol2qm74	2558	5	old	old	JJ
cord-015021-pol2qm74	2558	6	woman	woman	NN
cord-015021-pol2qm74	2558	7	in	in	IN
cord-015021-pol2qm74	2558	8	severe	severe	JJ
cord-015021-pol2qm74	2558	9	septic	septic	JJ
cord-015021-pol2qm74	2558	10	shock	shock	NN
cord-015021-pol2qm74	2558	11	due	due	IN
cord-015021-pol2qm74	2558	12	to	to	IN
cord-015021-pol2qm74	2558	13	a	a	DT
cord-015021-pol2qm74	2558	14	Candida	Candida	NNP
cord-015021-pol2qm74	2558	15	and	and	CC
cord-015021-pol2qm74	2558	16	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	2558	17	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	2558	18	infection	infection	NN
cord-015021-pol2qm74	2558	19	complicated	complicate	VBN
cord-015021-pol2qm74	2558	20	by	by	IN
cord-015021-pol2qm74	2558	21	adult	adult	NN
cord-015021-pol2qm74	2558	22	-	-	HYPH
cord-015021-pol2qm74	2558	23	respiratorydistress	respiratorydistress	NN
cord-015021-pol2qm74	2558	24	-	-	HYPH
cord-015021-pol2qm74	2558	25	syndrome	syndrome	NN
cord-015021-pol2qm74	2558	26	conditions	condition	NNS
cord-015021-pol2qm74	2558	27	deteriorated	deteriorate	VBD
cord-015021-pol2qm74	2558	28	despite	despite	IN
cord-015021-pol2qm74	2558	29	adequate	adequate	JJ
cord-015021-pol2qm74	2558	30	conventional	conventional	JJ
cord-015021-pol2qm74	2558	31	therapy	therapy	NN
cord-015021-pol2qm74	2558	32	.	.	.
cord-015021-pol2qm74	2559	1	In	in	IN
cord-015021-pol2qm74	2559	2	this	this	DT
cord-015021-pol2qm74	2559	3	trial	trial	NN
cord-015021-pol2qm74	2559	4	,	,	,
cord-015021-pol2qm74	2559	5	effects	effect	NNS
cord-015021-pol2qm74	2559	6	of	of	IN
cord-015021-pol2qm74	2559	7	L	L	NNP
cord-015021-pol2qm74	2559	8	-	-	HYPH
cord-015021-pol2qm74	2559	9	NMMA	NMMA	NNP
cord-015021-pol2qm74	2559	10	on	on	IN
cord-015021-pol2qm74	2559	11	cytokin	cytokin	NN
cord-015021-pol2qm74	2559	12	-	-	HYPH
cord-015021-pol2qm74	2559	13	levels	level	NNS
cord-015021-pol2qm74	2559	14	were	be	VBD
cord-015021-pol2qm74	2559	15	investigated	investigate	VBN
cord-015021-pol2qm74	2559	16	.	.	.
cord-015021-pol2qm74	2560	1	The	the	DT
cord-015021-pol2qm74	2560	2	study	study	NN
cord-015021-pol2qm74	2560	3	-	-	HYPH
cord-015021-pol2qm74	2560	4	protocol	protocol	NN
cord-015021-pol2qm74	2560	5	was	be	VBD
cord-015021-pol2qm74	2560	6	approved	approve	VBN
cord-015021-pol2qm74	2560	7	by	by	IN
cord-015021-pol2qm74	2560	8	the	the	DT
cord-015021-pol2qm74	2560	9	ethical	ethical	JJ
cord-015021-pol2qm74	2560	10	committee	committee	NN
cord-015021-pol2qm74	2560	11	of	of	IN
cord-015021-pol2qm74	2560	12	the	the	DT
cord-015021-pol2qm74	2560	13	Department	Department	NNP
cord-015021-pol2qm74	2560	14	of	of	IN
cord-015021-pol2qm74	2560	15	Surgery	Surgery	NNP
cord-015021-pol2qm74	2560	16	.	.	.
cord-015021-pol2qm74	2561	1	After	after	IN
cord-015021-pol2qm74	2561	2	two	two	CD
cord-015021-pol2qm74	2561	3	boll	boll	NNS
cord-015021-pol2qm74	2561	4	of	of	IN
cord-015021-pol2qm74	2561	5	200	200	CD
cord-015021-pol2qm74	2561	6	mg	mg	NN
cord-015021-pol2qm74	2561	7	of	of	IN
cord-015021-pol2qm74	2561	8	L	L	NNP
cord-015021-pol2qm74	2561	9	-	-	HYPH
cord-015021-pol2qm74	2561	10	NMMA	NMMA	NNP
cord-015021-pol2qm74	2561	11	,	,	,
cord-015021-pol2qm74	2561	12	a	a	DT
cord-015021-pol2qm74	2561	13	continuous	continuous	JJ
cord-015021-pol2qm74	2561	14	infusion	infusion	NN
cord-015021-pol2qm74	2561	15	was	be	VBD
cord-015021-pol2qm74	2561	16	installed	instal	VBN
cord-015021-pol2qm74	2561	17	(	(	-LRB-
cord-015021-pol2qm74	2561	18	0.05	0.05	CD
cord-015021-pol2qm74	2561	19	mg	mg	NNP
cord-015021-pol2qm74	2561	20	/	/	SYM
cord-015021-pol2qm74	2561	21	minute	minute	NN
cord-015021-pol2qm74	2561	22	and	and	CC
cord-015021-pol2qm74	2561	23	kg	kg	NN
cord-015021-pol2qm74	2561	24	body	body	NN
cord-015021-pol2qm74	2561	25	weight	weight	NN
cord-015021-pol2qm74	2561	26	L	L	NNP
cord-015021-pol2qm74	2561	27	-	-	HYPH
cord-015021-pol2qm74	2561	28	NMMA	NMMA	NNP
cord-015021-pol2qm74	2561	29	)	)	-RRB-
cord-015021-pol2qm74	2561	30	.	.	.
cord-015021-pol2qm74	2562	1	As	as	IN
cord-015021-pol2qm74	2562	2	expected	expect	VBN
cord-015021-pol2qm74	2562	3	mean	mean	VBP
cord-015021-pol2qm74	2562	4	arterial	arterial	JJ
cord-015021-pol2qm74	2562	5	blood	blood	NN
cord-015021-pol2qm74	2562	6	pressure	pressure	NN
cord-015021-pol2qm74	2562	7	rose	rise	VBD
cord-015021-pol2qm74	2562	8	(	(	-LRB-
cord-015021-pol2qm74	2562	9	62	62	CD
cord-015021-pol2qm74	2562	10	to	to	TO
cord-015021-pol2qm74	2562	11	134	134	CD
cord-015021-pol2qm74	2562	12	mmHg	mmHg	NNS
cord-015021-pol2qm74	2562	13	}	}	-RRB-
cord-015021-pol2qm74	2562	14	,	,	,
cord-015021-pol2qm74	2562	15	heart	heart	NN
cord-015021-pol2qm74	2562	16	rate	rate	NN
cord-015021-pol2qm74	2562	17	stayed	stay	VBD
cord-015021-pol2qm74	2562	18	stable	stable	JJ
cord-015021-pol2qm74	2562	19	(	(	-LRB-
cord-015021-pol2qm74	2562	20	124	124	CD
cord-015021-pol2qm74	2562	21	+	+	SYM
cord-015021-pol2qm74	2562	22	4	4	CD
cord-015021-pol2qm74	2562	23	b	b	NN
cord-015021-pol2qm74	2562	24	/	/	SYM
cord-015021-pol2qm74	2562	25	rain	rain	NN
cord-015021-pol2qm74	2562	26	)	)	-RRB-
cord-015021-pol2qm74	2562	27	,	,	,
cord-015021-pol2qm74	2562	28	systemic	systemic	JJ
cord-015021-pol2qm74	2562	29	vascular	vascular	JJ
cord-015021-pol2qm74	2562	30	resistance	resistance	NN
cord-015021-pol2qm74	2562	31	increased	increase	VBD
cord-015021-pol2qm74	2562	32	(	(	-LRB-
cord-015021-pol2qm74	2562	33	225	225	CD
cord-015021-pol2qm74	2562	34	to	to	IN
cord-015021-pol2qm74	2562	35	354	354	CD
cord-015021-pol2qm74	2562	36	dyne.sec/cm5	dyne.sec/cm5	NNP
cord-015021-pol2qm74	2562	37	)	)	-RRB-
cord-015021-pol2qm74	2562	38	,	,	,
cord-015021-pol2qm74	2562	39	cardiac	cardiac	JJ
cord-015021-pol2qm74	2562	40	output	output	NN
cord-015021-pol2qm74	2562	41	decreased	decrease	VBD
cord-015021-pol2qm74	2562	42	(	(	-LRB-
cord-015021-pol2qm74	2562	43	17	17	CD
cord-015021-pol2qm74	2562	44	to	to	IN
cord-015021-pol2qm74	2562	45	15.2	15.2	CD
cord-015021-pol2qm74	2562	46	L	l	NN
cord-015021-pol2qm74	2562	47	/	/	SYM
cord-015021-pol2qm74	2562	48	rain	rain	NN
cord-015021-pol2qm74	2562	49	)	)	-RRB-
cord-015021-pol2qm74	2562	50	,	,	,
cord-015021-pol2qm74	2562	51	and	and	CC
cord-015021-pol2qm74	2562	52	cardiac	cardiac	JJ
cord-015021-pol2qm74	2562	53	index	index	NN
cord-015021-pol2qm74	2562	54	declined	decline	VBD
cord-015021-pol2qm74	2562	55	(	(	-LRB-
cord-015021-pol2qm74	2562	56	9.94	9.94	CD
cord-015021-pol2qm74	2562	57	to	to	IN
cord-015021-pol2qm74	2562	58	8.63	8.63	CD
cord-015021-pol2qm74	2562	59	L	L	NNP
cord-015021-pol2qm74	2562	60	/	/	SYM
cord-015021-pol2qm74	2562	61	min	min	NNP
cord-015021-pol2qm74	2562	62	/	/	SYM
cord-015021-pol2qm74	2562	63	m2	m2	NNP
cord-015021-pol2qm74	2562	64	}	}	-RRB-
cord-015021-pol2qm74	2562	65	.	.	.
cord-015021-pol2qm74	2563	1	Before	before	IN
cord-015021-pol2qm74	2563	2	and	and	CC
cord-015021-pol2qm74	2563	3	after	after	IN
cord-015021-pol2qm74	2563	4	90	90	CD
cord-015021-pol2qm74	2563	5	minutes	minute	NNS
cord-015021-pol2qm74	2563	6	while	while	IN
cord-015021-pol2qm74	2563	7	the	the	DT
cord-015021-pol2qm74	2563	8	infusion	infusion	NN
cord-015021-pol2qm74	2563	9	of	of	IN
cord-015021-pol2qm74	2563	10	L	L	NNP
cord-015021-pol2qm74	2563	11	-	-	HYPH
cord-015021-pol2qm74	2563	12	NMMA	NMMA	NNP
cord-015021-pol2qm74	2563	13	,	,	,
cord-015021-pol2qm74	2563	14	blood	blood	NN
cord-015021-pol2qm74	2563	15	samples	sample	NNS
cord-015021-pol2qm74	2563	16	for	for	IN
cord-015021-pol2qm74	2563	17	immunological	immunological	JJ
cord-015021-pol2qm74	2563	18	measurements	measurement	NNS
cord-015021-pol2qm74	2563	19	were	be	VBD
cord-015021-pol2qm74	2563	20	taken	take	VBN
cord-015021-pol2qm74	2563	21	and	and	CC
cord-015021-pol2qm74	2563	22	processed	process	VBN
cord-015021-pol2qm74	2563	23	together	together	RB
cord-015021-pol2qm74	2563	24	.	.	.
cord-015021-pol2qm74	2564	1	Pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2564	2	-	-	HYPH
cord-015021-pol2qm74	2564	3	shunt	shunt	NN
cord-015021-pol2qm74	2564	4	-	-	HYPH
cord-015021-pol2qm74	2564	5	volume	volume	NN
cord-015021-pol2qm74	2564	6	was	be	VBD
cord-015021-pol2qm74	2564	7	observed	observe	VBN
cord-015021-pol2qm74	2564	8	before	before	IN
cord-015021-pol2qm74	2564	9	the	the	DT
cord-015021-pol2qm74	2564	10	application	application	NN
cord-015021-pol2qm74	2564	11	of	of	IN
cord-015021-pol2qm74	2564	12	L	L	NNP
cord-015021-pol2qm74	2564	13	-	-	HYPH
cord-015021-pol2qm74	2564	14	NMMA	NMMA	NNP
cord-015021-pol2qm74	2564	15	,	,	,
cord-015021-pol2qm74	2564	16	after	after	IN
cord-015021-pol2qm74	2564	17	one	one	CD
cord-015021-pol2qm74	2564	18	hour	hour	NN
cord-015021-pol2qm74	2564	19	and	and	CC
cord-015021-pol2qm74	2564	20	after	after	IN
cord-015021-pol2qm74	2564	21	140	140	CD
cord-015021-pol2qm74	2564	22	matutes	matute	NNS
cord-015021-pol2qm74	2564	23	.	.	.
cord-015021-pol2qm74	2565	1	Neopterine	Neopterine	NNP
cord-015021-pol2qm74	2565	2	increased	increase	VBD
cord-015021-pol2qm74	2565	3	from	from	IN
cord-015021-pol2qm74	2565	4	16.51	16.51	CD
cord-015021-pol2qm74	2565	5	to	to	IN
cord-015021-pol2qm74	2565	6	32.55	32.55	CD
cord-015021-pol2qm74	2565	7	ng	ng	NN
cord-015021-pol2qm74	2565	8	/	/	SYM
cord-015021-pol2qm74	2565	9	ml	ml	NN
cord-015021-pol2qm74	2565	10	,	,	,
cord-015021-pol2qm74	2565	11	tumour	tumour	NN
cord-015021-pol2qm74	2565	12	-	-	HYPH
cord-015021-pol2qm74	2565	13	necrosis	necrosis	NN
cord-015021-pol2qm74	2565	14	-	-	HYPH
cord-015021-pol2qm74	2565	15	factor	factor	NN
cord-015021-pol2qm74	2565	16	-	-	:
cord-015021-pol2qm74	2565	17	a	a	DT
cord-015021-pol2qm74	2565	18	increased	increase	VBD
cord-015021-pol2qm74	2565	19	from	from	IN
cord-015021-pol2qm74	2565	20	24.16	24.16	CD
cord-015021-pol2qm74	2565	21	to	to	IN
cord-015021-pol2qm74	2565	22	36.61	36.61	CD
cord-015021-pol2qm74	2565	23	pg	pg	NNS
cord-015021-pol2qm74	2565	24	/	/	SYM
cord-015021-pol2qm74	2565	25	ml	ml	NNP
cord-015021-pol2qm74	2565	26	and	and	CC
cord-015021-pol2qm74	2565	27	intedeukin-6	intedeukin-6	NNP
cord-015021-pol2qm74	2565	28	increased	increase	VBD
cord-015021-pol2qm74	2565	29	from	from	IN
cord-015021-pol2qm74	2565	30	61.9	61.9	CD
cord-015021-pol2qm74	2565	31	to	to	IN
cord-015021-pol2qm74	2565	32	98.2	98.2	CD
cord-015021-pol2qm74	2565	33	pg	pg	NN
cord-015021-pol2qm74	2565	34	/	/	SYM
cord-015021-pol2qm74	2565	35	ml	ml	NN
cord-015021-pol2qm74	2565	36	.	.	.
cord-015021-pol2qm74	2566	1	Immunoglobulines	Immunoglobulines	NNP
cord-015021-pol2qm74	2566	2	A	A	NNP
cord-015021-pol2qm74	2566	3	,	,	,
cord-015021-pol2qm74	2566	4	G	g	NN
cord-015021-pol2qm74	2566	5	,	,	,
cord-015021-pol2qm74	2566	6	and	and	CC
cord-015021-pol2qm74	2566	7	M	M	NNP
cord-015021-pol2qm74	2566	8	(	(	-LRB-
cord-015021-pol2qm74	2566	9	3.2	3.2	CD
cord-015021-pol2qm74	2566	10	to	to	IN
cord-015021-pol2qm74	2566	11	2.9	2.9	CD
cord-015021-pol2qm74	2566	12	,	,	,
cord-015021-pol2qm74	2566	13	8.1	8.1	CD
cord-015021-pol2qm74	2566	14	to	to	IN
cord-015021-pol2qm74	2566	15	7.6	7.6	CD
cord-015021-pol2qm74	2566	16	,	,	,
cord-015021-pol2qm74	2566	17	1.1	1.1	CD
cord-015021-pol2qm74	2566	18	to	to	TO
cord-015021-pol2qm74	2566	19	0.9	0.9	CD
cord-015021-pol2qm74	2566	20	g	g	NN
cord-015021-pol2qm74	2566	21	/	/	SYM
cord-015021-pol2qm74	2566	22	I	i	NN
cord-015021-pol2qm74	2566	23	)	)	-RRB-
cord-015021-pol2qm74	2566	24	,	,	,
cord-015021-pol2qm74	2566	25	Complement	Complement	NNP
cord-015021-pol2qm74	2566	26	factor	factor	NN
cord-015021-pol2qm74	2566	27	C-3c	c-3c	NN
cord-015021-pol2qm74	2566	28	and	and	CC
cord-015021-pol2qm74	2566	29	C-4	C-4	NNP
cord-015021-pol2qm74	2566	30	(	(	-LRB-
cord-015021-pol2qm74	2566	31	0.54	0.54	CD
cord-015021-pol2qm74	2566	32	to	to	IN
cord-015021-pol2qm74	2566	33	0.50	0.50	CD
cord-015021-pol2qm74	2566	34	,	,	,
cord-015021-pol2qm74	2566	35	0.22	0.22	CD
cord-015021-pol2qm74	2566	36	to	to	IN
cord-015021-pol2qm74	2566	37	0.23	0.23	CD
cord-015021-pol2qm74	2566	38	g	g	NN
cord-015021-pol2qm74	2566	39	/	/	SYM
cord-015021-pol2qm74	2566	40	I	i	NN
cord-015021-pol2qm74	2566	41	)	)	-RRB-
cord-015021-pol2qm74	2566	42	,	,	,
cord-015021-pol2qm74	2566	43	alpha	alpha	NN
cord-015021-pol2qm74	2566	44	-	-	HYPH
cord-015021-pol2qm74	2566	45	l	l	NN
cord-015021-pol2qm74	2566	46	-	-	HYPH
cord-015021-pol2qm74	2566	47	antitrypsine	antitrypsine	NNP
cord-015021-pol2qm74	2566	48	(	(	-LRB-
cord-015021-pol2qm74	2566	49	3.86	3.86	CD
cord-015021-pol2qm74	2566	50	to	to	TO
cord-015021-pol2qm74	2566	51	3.83	3.83	CD
cord-015021-pol2qm74	2566	52	g	g	NN
cord-015021-pol2qm74	2566	53	/	/	SYM
cord-015021-pol2qm74	2566	54	I	i	NN
cord-015021-pol2qm74	2566	55	)	)	-RRB-
cord-015021-pol2qm74	2566	56	,	,	,
cord-015021-pol2qm74	2566	57	C	c	NN
cord-015021-pol2qm74	2566	58	-	-	HYPH
cord-015021-pol2qm74	2566	59	reactive	reactive	JJ
cord-015021-pol2qm74	2566	60	-	-	HYPH
cord-015021-pol2qm74	2566	61	protein	protein	NN
cord-015021-pol2qm74	2566	62	(	(	-LRB-
cord-015021-pol2qm74	2566	63	111.1	111.1	CD
cord-015021-pol2qm74	2566	64	to	to	IN
cord-015021-pol2qm74	2566	65	105.6	105.6	CD
cord-015021-pol2qm74	2566	66	rag	rag	NN
cord-015021-pol2qm74	2566	67	/	/	,
cord-015021-pol2qm74	2566	68	I	i	NN
cord-015021-pol2qm74	2566	69	)	)	-RRB-
cord-015021-pol2qm74	2566	70	,	,	,
cord-015021-pol2qm74	2566	71	interleukin-1	interleukin-1	NN
cord-015021-pol2qm74	2566	72	(	(	-LRB-
cord-015021-pol2qm74	2566	73	0	0	CD
cord-015021-pol2qm74	2566	74	pg	pg	NN
cord-015021-pol2qm74	2566	75	/	/	SYM
cord-015021-pol2qm74	2566	76	ml	ml	NN
cord-015021-pol2qm74	2566	77	)	)	-RRB-
cord-015021-pol2qm74	2566	78	and	and	CC
cord-015021-pol2qm74	2566	79	soluble	soluble	JJ
cord-015021-pol2qm74	2566	80	interleukin-2	interleukin-2	IN
cord-015021-pol2qm74	2566	81	(	(	-LRB-
cord-015021-pol2qm74	2566	82	2128	2128	CD
cord-015021-pol2qm74	2566	83	to	to	IN
cord-015021-pol2qm74	2566	84	1983	1983	CD
cord-015021-pol2qm74	2566	85	Units	Units	NNP
cord-015021-pol2qm74	2566	86	/	/	SYM
cord-015021-pol2qm74	2566	87	ml	ml	NN
cord-015021-pol2qm74	2566	88	)	)	-RRB-
cord-015021-pol2qm74	2566	89	did	do	VBD
cord-015021-pol2qm74	2566	90	not	not	RB
cord-015021-pol2qm74	2566	91	change	change	VB
cord-015021-pol2qm74	2566	92	significantly	significantly	RB
cord-015021-pol2qm74	2566	93	.	.	.
cord-015021-pol2qm74	2567	1	Pulmonary	Pulmonary	NNP
cord-015021-pol2qm74	2567	2	-	-	HYPH
cord-015021-pol2qm74	2567	3	shuntvolume	shuntvolume	NN
cord-015021-pol2qm74	2567	4	decreased	decrease	VBD
cord-015021-pol2qm74	2567	5	from	from	IN
cord-015021-pol2qm74	2567	6	54.1	54.1	CD
cord-015021-pol2qm74	2567	7	%	%	NN
cord-015021-pol2qm74	2567	8	to	to	IN
cord-015021-pol2qm74	2567	9	35.4	35.4	CD
cord-015021-pol2qm74	2567	10	%	%	NN
cord-015021-pol2qm74	2567	11	within	within	IN
cord-015021-pol2qm74	2567	12	one	one	CD
cord-015021-pol2qm74	2567	13	hour	hour	NN
cord-015021-pol2qm74	2567	14	and	and	CC
cord-015021-pol2qm74	2567	15	to	to	IN
cord-015021-pol2qm74	2567	16	36.6	36.6	CD
cord-015021-pol2qm74	2567	17	%	%	NN
cord-015021-pol2qm74	2567	18	after	after	IN
cord-015021-pol2qm74	2567	19	140	140	CD
cord-015021-pol2qm74	2567	20	minutes	minute	NNS
cord-015021-pol2qm74	2567	21	.	.	.
cord-015021-pol2qm74	2568	1	In	in	IN
cord-015021-pol2qm74	2568	2	septic	septic	JJ
cord-015021-pol2qm74	2568	3	shock	shock	NN
cord-015021-pol2qm74	2568	4	blocking	block	VBG
cord-015021-pol2qm74	2568	5	nitric	nitric	NN
cord-015021-pol2qm74	2568	6	oxide	oxide	NN
cord-015021-pol2qm74	2568	7	as	as	IN
cord-015021-pol2qm74	2568	8	an	an	DT
cord-015021-pol2qm74	2568	9	intervention	intervention	NN
cord-015021-pol2qm74	2568	10	at	at	IN
cord-015021-pol2qm74	2568	11	the	the	DT
cord-015021-pol2qm74	2568	12	end	end	NN
cord-015021-pol2qm74	2568	13	of	of	IN
cord-015021-pol2qm74	2568	14	a	a	DT
cord-015021-pol2qm74	2568	15	not	not	RB
cord-015021-pol2qm74	2568	16	~,et	~,et	JJ
cord-015021-pol2qm74	2569	1	ful!y	ful!y	NNP
cord-015021-pol2qm74	2569	2	understood	understand	VBD
cord-015021-pol2qm74	2569	3	cascade	cascade	NN
cord-015021-pol2qm74	2569	4	might	may	MD
cord-015021-pol2qm74	2569	5	have	have	VB
cord-015021-pol2qm74	2569	6	important	important	JJ
cord-015021-pol2qm74	2569	7	influences	influence	NNS
cord-015021-pol2qm74	2569	8	on	on	IN
cord-015021-pol2qm74	2569	9	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2569	10	-	-	HYPH
cord-015021-pol2qm74	2569	11	shunt	shunt	NN
cord-015021-pol2qm74	2569	12	-	-	HYPH
cord-015021-pol2qm74	2569	13	volume	volume	NN
cord-015021-pol2qm74	2569	14	and	and	CC
cord-015021-pol2qm74	2569	15	inter	inter	JJ
cord-015021-pol2qm74	2569	16	-	-	JJ
cord-015021-pol2qm74	2569	17	cell	cell	NN
cord-015021-pol2qm74	2569	18	-	-	HYPH
cord-015021-pol2qm74	2569	19	communication	communication	NN
cord-015021-pol2qm74	2569	20	.	.	.
cord-015021-pol2qm74	2570	1	Department	Department	NNP
cord-015021-pol2qm74	2570	2	of	of	IN
cord-015021-pol2qm74	2570	3	Surgery	Surgery	NNP
cord-015021-pol2qm74	2570	4	,	,	,
cord-015021-pol2qm74	2570	5	Pharmacy	Pharmacy	NNP
cord-015021-pol2qm74	2570	6	*	*	NFP
cord-015021-pol2qm74	2570	7	and	and	CC
cord-015021-pol2qm74	2570	8	Immunology	Immunology	NNP
cord-015021-pol2qm74	2571	1	*	*	NFP
cord-015021-pol2qm74	2571	2	*	*	NFP
cord-015021-pol2qm74	2571	3	,	,	,
cord-015021-pol2qm74	2571	4	University	University	NNP
cord-015021-pol2qm74	2571	5	Hospital	Hospital	NNP
cord-015021-pol2qm74	2571	6	of	of	IN
cord-015021-pol2qm74	2571	7	Zurich	Zurich	NNP
cord-015021-pol2qm74	2571	8	,	,	,
cord-015021-pol2qm74	2572	1	R	R	NNP
cord-015021-pol2qm74	2572	2	~	~	CD
cord-015021-pol2qm74	2572	3	imistrasse	imistrasse	NNP
cord-015021-pol2qm74	2572	4	100	100	CD
cord-015021-pol2qm74	2572	5	,	,	,
cord-015021-pol2qm74	2572	6	8091	8091	CD
cord-015021-pol2qm74	2572	7	Zurich	Zurich	NNP
cord-015021-pol2qm74	2572	8	,	,	,
cord-015021-pol2qm74	2572	9	Switzerland	Switzerland	NNP
cord-015021-pol2qm74	2573	1	We	-PRON-	PRP
cord-015021-pol2qm74	2573	2	previously	previously	RB
cord-015021-pol2qm74	2573	3	reported	report	VBD
cord-015021-pol2qm74	2573	4	that	that	IN
cord-015021-pol2qm74	2573	5	hypoferremic	hypoferremic	NN
cord-015021-pol2qm74	2573	6	CBA	CBA	NNP
cord-015021-pol2qm74	2573	7	mice	mouse	NNS
cord-015021-pol2qm74	2573	8	had	have	VBD
cord-015021-pol2qm74	2573	9	an	an	DT
cord-015021-pol2qm74	2573	10	increased	increase	VBN
cord-015021-pol2qm74	2573	11	resistance	resistance	NN
cord-015021-pol2qm74	2573	12	to	to	IN
cord-015021-pol2qm74	2573	13	Salmonella	salmonella	NN
cord-015021-pol2qm74	2573	14	infection	infection	NN
cord-015021-pol2qm74	2573	15	,	,	,
cord-015021-pol2qm74	2573	16	and	and	CC
cord-015021-pol2qm74	2573	17	that	that	DT
cord-015021-pol2qm74	2573	18	injection	injection	NN
cord-015021-pol2qm74	2573	19	of	of	IN
cord-015021-pol2qm74	2573	20	Ammonium	Ammonium	NNP
cord-015021-pol2qm74	2573	21	Ferric	Ferric	NNP
cord-015021-pol2qm74	2573	22	Citrate	Citrate	NNP
cord-015021-pol2qm74	2573	23	(	(	-LRB-
cord-015021-pol2qm74	2573	24	AFC	AFC	NNP
cord-015021-pol2qm74	2573	25	)	)	-RRB-
cord-015021-pol2qm74	2573	26	to	to	IN
cord-015021-pol2qm74	2573	27	these	these	DT
cord-015021-pol2qm74	2573	28	mice	mouse	NNS
cord-015021-pol2qm74	2573	29	led	lead	VBD
cord-015021-pol2qm74	2573	30	to	to	IN
cord-015021-pol2qm74	2573	31	enhanced	enhance	VBN
cord-015021-pol2qm74	2573	32	infection	infection	NN
cord-015021-pol2qm74	2573	33	(	(	-LRB-
cord-015021-pol2qm74	2573	34	Ganthier	Ganthier	NNP
cord-015021-pol2qm74	2573	35	et	et	NNP
cord-015021-pol2qm74	2573	36	at	at	IN
cord-015021-pol2qm74	2573	37	.	.	.
cord-015021-pol2qm74	2573	38	1986	1986	CD
cord-015021-pol2qm74	2573	39	.	.	.
cord-015021-pol2qm74	2574	1	Microbiol	Microbiol	NNP
cord-015021-pol2qm74	2574	2	.	.	.
cord-015021-pol2qm74	2575	1	Immuno130:425	Immuno130:425	NNP
cord-015021-pol2qm74	2575	2	)	)	-RRB-
cord-015021-pol2qm74	2575	3	.	.	.
cord-015021-pol2qm74	2576	1	Because	because	IN
cord-015021-pol2qm74	2576	2	Nitric	nitric	NN
cord-015021-pol2qm74	2576	3	Oxide	Oxide	NNP
cord-015021-pol2qm74	2576	4	(	(	-LRB-
cord-015021-pol2qm74	2576	5	NO	no	UH
cord-015021-pol2qm74	2576	6	)	)	-RRB-
cord-015021-pol2qm74	2576	7	is	be	VBZ
cord-015021-pol2qm74	2576	8	involved	involve	VBN
cord-015021-pol2qm74	2576	9	in	in	IN
cord-015021-pol2qm74	2576	10	the	the	DT
cord-015021-pol2qm74	2576	11	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	2576	12	activity	activity	NN
cord-015021-pol2qm74	2576	13	of	of	IN
cord-015021-pol2qm74	2576	14	routine	routine	JJ
cord-015021-pol2qm74	2576	15	macmphages	macmphage	NNS
cord-015021-pol2qm74	2576	16	towards	towards	IN
cord-015021-pol2qm74	2576	17	various	various	JJ
cord-015021-pol2qm74	2576	18	inttacellular	inttacellular	JJ
cord-015021-pol2qm74	2576	19	pathogens	pathogen	NNS
cord-015021-pol2qm74	2576	20	,	,	,
cord-015021-pol2qm74	2576	21	we	-PRON-	PRP
cord-015021-pol2qm74	2576	22	investigated	investigate	VBD
cord-015021-pol2qm74	2576	23	the	the	DT
cord-015021-pol2qm74	2576	24	influence	influence	NN
cord-015021-pol2qm74	2576	25	of	of	IN
cord-015021-pol2qm74	2576	26	iron	iron	NN
cord-015021-pol2qm74	2576	27	on	on	IN
cord-015021-pol2qm74	2576	28	the	the	DT
cord-015021-pol2qm74	2576	29	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	2576	30	activity	activity	NN
cord-015021-pol2qm74	2576	31	of	of	IN
cord-015021-pol2qm74	2576	32	CBA	CBA	NNP
cord-015021-pol2qm74	2576	33	mouse	mouse	NN
cord-015021-pol2qm74	2576	34	macrophages	macrophage	NNS
cord-015021-pol2qm74	2576	35	towards	towards	IN
cord-015021-pol2qm74	2576	36	S.typhimurium	s.typhimurium	NN
cord-015021-pol2qm74	2576	37	and	and	CC
cord-015021-pol2qm74	2576	38	on	on	IN
cord-015021-pol2qm74	2576	39	the	the	DT
cord-015021-pol2qm74	2576	40	production	production	NN
cord-015021-pol2qm74	2576	41	and	and	CC
cord-015021-pol2qm74	2576	42	activity	activity	NN
cord-015021-pol2qm74	2576	43	of	of	IN
cord-015021-pol2qm74	2576	44	Reactive	Reactive	NNP
cord-015021-pol2qm74	2576	45	Nitrogen	Nitrogen	NNP
cord-015021-pol2qm74	2576	46	Intermediates	Intermediates	NNPS
cord-015021-pol2qm74	2576	47	(	(	-LRB-
cord-015021-pol2qm74	2576	48	RNI	RNI	NNP
cord-015021-pol2qm74	2576	49	)	)	-RRB-
cord-015021-pol2qm74	2576	50	.	.	.
cord-015021-pol2qm74	2577	1	Peritoneal	peritoneal	JJ
cord-015021-pol2qm74	2577	2	macrophages	macrophage	NNS
cord-015021-pol2qm74	2577	3	hum	hum	VBP
cord-015021-pol2qm74	2577	4	CBA	CBA	NNP
cord-015021-pol2qm74	2577	5	mice	mouse	NNS
cord-015021-pol2qm74	2577	6	were	be	VBD
cord-015021-pol2qm74	2577	7	cultured	culture	VBN
cord-015021-pol2qm74	2577	8	in	in	IN
cord-015021-pol2qm74	2577	9	the	the	DT
cord-015021-pol2qm74	2577	10	presence	presence	NN
cord-015021-pol2qm74	2577	11	(	(	-LRB-
cord-015021-pol2qm74	2577	12	or	or	CC
cord-015021-pol2qm74	2577	13	not	not	RB
cord-015021-pol2qm74	2577	14	)	)	-RRB-
cord-015021-pol2qm74	2577	15	of	of	IN
cord-015021-pol2qm74	2577	16	AFC	AFC	NNP
cord-015021-pol2qm74	2577	17	50	50	CD
cord-015021-pol2qm74	2577	18	,	,	,
cord-015021-pol2qm74	2577	19	uM	um	UH
cord-015021-pol2qm74	2577	20	,	,	,
cord-015021-pol2qm74	2577	21	IFN-,/250	IFN-,/250	NNP
cord-015021-pol2qm74	2577	22	U	U	NNP
cord-015021-pol2qm74	2577	23	/	/	SYM
cord-015021-pol2qm74	2577	24	ml	ml	XX
cord-015021-pol2qm74	2577	25	,	,	,
cord-015021-pol2qm74	2577	26	LPS	LPS	NNP
cord-015021-pol2qm74	2577	27	1	1	CD
cord-015021-pol2qm74	2577	28	fig	fig	NN
cord-015021-pol2qm74	2577	29	/	/	SYM
cord-015021-pol2qm74	2577	30	m/	m/	JJ
cord-015021-pol2qm74	2577	31	,	,	,
cord-015021-pol2qm74	2577	32	NGMonomethyl	NGMonomethyl	NNP
cord-015021-pol2qm74	2577	33	-	-	HYPH
cord-015021-pol2qm74	2577	34	L	l	NN
cord-015021-pol2qm74	2577	35	--	--	:
cord-015021-pol2qm74	2577	36	Arginine	arginine	NN
cord-015021-pol2qm74	2577	37	(	(	-LRB-
cord-015021-pol2qm74	2577	38	MMLA	MMLA	NNP
cord-015021-pol2qm74	2577	39	)	)	-RRB-
cord-015021-pol2qm74	2578	1	2raM.	2ram.	CD
cord-015021-pol2qm74	2579	1	Nitrite	nitrite	NN
cord-015021-pol2qm74	2579	2	(	(	-LRB-
cord-015021-pol2qm74	2579	3	NO2-	NO2-	NNP
cord-015021-pol2qm74	2579	4	)	)	-RRB-
cord-015021-pol2qm74	2579	5	content	content	NN
cord-015021-pol2qm74	2579	6	of	of	IN
cord-015021-pol2qm74	2579	7	the	the	DT
cord-015021-pol2qm74	2579	8	supematants	supematant	NNS
cord-015021-pol2qm74	2579	9	was	be	VBD
cord-015021-pol2qm74	2579	10	determined	determine	VBN
cord-015021-pol2qm74	2579	11	by	by	IN
cord-015021-pol2qm74	2579	12	a	a	DT
cord-015021-pol2qm74	2579	13	standard	standard	JJ
cord-015021-pol2qm74	2579	14	Griess	Griess	NNP
cord-015021-pol2qm74	2579	15	reaction	reaction	NN
cord-015021-pol2qm74	2579	16	,	,	,
cord-015021-pol2qm74	2579	17	and	and	CC
cord-015021-pol2qm74	2579	18	H202	h202	NN
cord-015021-pol2qm74	2579	19	release	release	NN
cord-015021-pol2qm74	2579	20	was	be	VBD
cord-015021-pol2qm74	2579	21	measured	measure	VBN
cord-015021-pol2qm74	2579	22	by	by	IN
cord-015021-pol2qm74	2579	23	the	the	DT
cord-015021-pol2qm74	2579	24	peroxidese	peroxidese	JJ
cord-015021-pol2qm74	2579	25	dependant	dependant	JJ
cord-015021-pol2qm74	2579	26	oxidation	oxidation	NN
cord-015021-pol2qm74	2579	27	of	of	IN
cord-015021-pol2qm74	2579	28	phenol	phenol	NN
cord-015021-pol2qm74	2579	29	red	red	NN
cord-015021-pol2qm74	2579	30	.	.	.
cord-015021-pol2qm74	2580	1	For	for	IN
cord-015021-pol2qm74	2580	2	intracellular	intracellular	JJ
cord-015021-pol2qm74	2580	3	killing	killing	NN
cord-015021-pol2qm74	2580	4	,	,	,
cord-015021-pol2qm74	2580	5	macrophages	macrophages	NN
cord-015021-pol2qm74	2580	6	monolayers	monolayer	NNS
cord-015021-pol2qm74	2580	7	were	be	VBD
cord-015021-pol2qm74	2580	8	infected	infect	VBN
cord-015021-pol2qm74	2580	9	,	,	,
cord-015021-pol2qm74	2580	10	and	and	CC
cord-015021-pol2qm74	2580	11	,	,	,
cord-015021-pol2qm74	2580	12	at	at	IN
cord-015021-pol2qm74	2580	13	various	various	JJ
cord-015021-pol2qm74	2580	14	intervals	interval	NNS
cord-015021-pol2qm74	2580	15	,	,	,
cord-015021-pol2qm74	2580	16	lysed	lyse	VBN
cord-015021-pol2qm74	2580	17	by	by	IN
cord-015021-pol2qm74	2580	18	Triton	Triton	NNP
cord-015021-pol2qm74	2580	19	X-100	x-100	NN
cord-015021-pol2qm74	2580	20	,	,	,
cord-015021-pol2qm74	2580	21	and	and	CC
cord-015021-pol2qm74	2580	22	surviving	survive	VBG
cord-015021-pol2qm74	2580	23	bacteria	bacteria	NNS
cord-015021-pol2qm74	2580	24	enumerated	enumerate	VBN
cord-015021-pol2qm74	2580	25	by	by	IN
cord-015021-pol2qm74	2580	26	colony	colony	NN
cord-015021-pol2qm74	2580	27	counting	counting	NN
cord-015021-pol2qm74	2580	28	on	on	IN
cord-015021-pol2qm74	2580	29	agar	agar	NN
cord-015021-pol2qm74	2580	30	.	.	.
cord-015021-pol2qm74	2581	1	For	for	IN
cord-015021-pol2qm74	2581	2	in	in	IN
cord-015021-pol2qm74	2581	3	vivo	vivo	NN
cord-015021-pol2qm74	2581	4	experiments	experiment	NNS
cord-015021-pol2qm74	2581	5	,	,	,
cord-015021-pol2qm74	2581	6	mice	mouse	NNS
cord-015021-pol2qm74	2581	7	were	be	VBD
cord-015021-pol2qm74	2581	8	infected	infect	VBN
cord-015021-pol2qm74	2581	9	IP	ip	NN
cord-015021-pol2qm74	2581	10	with	with	IN
cord-015021-pol2qm74	2581	11	0.5	0.5	CD
cord-015021-pol2qm74	2581	12	ml	ml	NNS
cord-015021-pol2qm74	2581	13	of	of	IN
cord-015021-pol2qm74	2581	14	a	a	DT
cord-015021-pol2qm74	2581	15	suspension	suspension	NN
cord-015021-pol2qm74	2581	16	of	of	IN
cord-015021-pol2qm74	2581	17	5.10	5.10	CD
cord-015021-pol2qm74	2581	18	~	~	NFP
cord-015021-pol2qm74	2581	19	"	"	''
cord-015021-pol2qm74	2581	20	S.typhimurium	s.typhimurium	NN
cord-015021-pol2qm74	2581	21	,	,	,
cord-015021-pol2qm74	2581	22	strain	strain	VB
cord-015021-pol2qm74	2581	23	C5	c5	NN
cord-015021-pol2qm74	2581	24	,	,	,
cord-015021-pol2qm74	2581	25	and	and	CC
cord-015021-pol2qm74	2581	26	injected	inject	VBN
cord-015021-pol2qm74	2581	27	with	with	IN
cord-015021-pol2qm74	2581	28	Aminoguanidine	Aminoguanidine	NNP
cord-015021-pol2qm74	2581	29	(	(	-LRB-
cord-015021-pol2qm74	2581	30	AG	AG	NNP
cord-015021-pol2qm74	2581	31	)	)	-RRB-
cord-015021-pol2qm74	2581	32	1	1	CD
cord-015021-pol2qm74	2581	33	mg	mg	NNP
cord-015021-pol2qm74	2581	34	/	/	SYM
cord-015021-pol2qm74	2581	35	ml	ml	NN
cord-015021-pol2qm74	2581	36	in	in	IN
cord-015021-pol2qm74	2581	37	saline	saline	NN
cord-015021-pol2qm74	2581	38	.	.	.
cord-015021-pol2qm74	2582	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2582	2	results	result	NNS
cord-015021-pol2qm74	2582	3	show	show	VBP
cord-015021-pol2qm74	2582	4	that	that	IN
cord-015021-pol2qm74	2582	5	the	the	DT
cord-015021-pol2qm74	2582	6	RN	rn	NN
cord-015021-pol2qm74	2582	7	[	[	-LRB-
cord-015021-pol2qm74	2582	8	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2582	9	AG	AG	NNP
cord-015021-pol2qm74	2582	10	strongly	strongly	RB
cord-015021-pol2qm74	2582	11	accelerates	accelerate	VBZ
cord-015021-pol2qm74	2582	12	the	the	DT
cord-015021-pol2qm74	2582	13	mortality	mortality	NN
cord-015021-pol2qm74	2582	14	of	of	IN
cord-015021-pol2qm74	2582	15	infected	infected	JJ
cord-015021-pol2qm74	2582	16	mice	mouse	NNS
cord-015021-pol2qm74	2582	17	,	,	,
cord-015021-pol2qm74	2582	18	the	the	DT
cord-015021-pol2qm74	2582	19	survival	survival	NN
cord-015021-pol2qm74	2582	20	rate	rate	NN
cord-015021-pol2qm74	2582	21	decreasing	decrease	VBG
cord-015021-pol2qm74	2582	22	from	from	IN
cord-015021-pol2qm74	2582	23	60	60	CD
cord-015021-pol2qm74	2582	24	%	%	NN
cord-015021-pol2qm74	2582	25	in	in	IN
cord-015021-pol2qm74	2582	26	the	the	DT
cord-015021-pol2qm74	2582	27	control	control	NN
cord-015021-pol2qm74	2582	28	group	group	NN
cord-015021-pol2qm74	2582	29	to	to	IN
cord-015021-pol2qm74	2582	30	20	20	CD
cord-015021-pol2qm74	2582	31	%	%	NN
cord-015021-pol2qm74	2582	32	in	in	IN
cord-015021-pol2qm74	2582	33	the	the	DT
cord-015021-pol2qm74	2582	34	treated	treated	JJ
cord-015021-pol2qm74	2582	35	group	group	NN
cord-015021-pol2qm74	2582	36	,	,	,
cord-015021-pol2qm74	2582	37	10	10	CD
cord-015021-pol2qm74	2582	38	days	day	NNS
cord-015021-pol2qm74	2582	39	after	after	IN
cord-015021-pol2qm74	2582	40	challenge	challenge	NN
cord-015021-pol2qm74	2582	41	.	.	.
cord-015021-pol2qm74	2583	1	Correlatively	correlatively	RB
cord-015021-pol2qm74	2583	2	the	the	DT
cord-015021-pol2qm74	2583	3	RNI	RNI	NNP
cord-015021-pol2qm74	2583	4	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2583	5	MMLA	MMLA	NNP
cord-015021-pol2qm74	2583	6	induces	induce	VBZ
cord-015021-pol2qm74	2583	7	in	in	IN
cord-015021-pol2qm74	2583	8	vitro	vitro	FW
cord-015021-pol2qm74	2583	9	a	a	DT
cord-015021-pol2qm74	2583	10	decrease	decrease	NN
cord-015021-pol2qm74	2583	11	in	in	IN
cord-015021-pol2qm74	2583	12	the	the	DT
cord-015021-pol2qm74	2583	13	rate	rate	NN
cord-015021-pol2qm74	2583	14	of	of	IN
cord-015021-pol2qm74	2583	15	bacterial	bacterial	JJ
cord-015021-pol2qm74	2583	16	killing	killing	NN
cord-015021-pol2qm74	2583	17	,	,	,
cord-015021-pol2qm74	2583	18	fxom	fxom	NNP
cord-015021-pol2qm74	2583	19	78	78	CD
cord-015021-pol2qm74	2583	20	%	%	NN
cord-015021-pol2qm74	2583	21	to	to	IN
cord-015021-pol2qm74	2583	22	57	57	CD
cord-015021-pol2qm74	2583	23	%	%	NN
cord-015021-pol2qm74	2583	24	,	,	,
cord-015021-pol2qm74	2583	25	in	in	IN
cord-015021-pol2qm74	2583	26	macrophages	macrophage	NNS
cord-015021-pol2qm74	2583	27	triggered	trigger	VBN
cord-015021-pol2qm74	2583	28	with	with	IN
cord-015021-pol2qm74	2583	29	IFN-	IFN-	NNP
cord-015021-pol2qm74	2583	30	?	?	.
cord-015021-pol2qm74	2583	31	+	+	NFP
cord-015021-pol2qm74	2583	32	LPS	lp	NNS
cord-015021-pol2qm74	2583	33	.	.	.
cord-015021-pol2qm74	2584	1	The	the	DT
cord-015021-pol2qm74	2584	2	cultivation	cultivation	NN
cord-015021-pol2qm74	2584	3	of	of	IN
cord-015021-pol2qm74	2584	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	2584	5	in	in	IN
cord-015021-pol2qm74	2584	6	the	the	DT
cord-015021-pol2qm74	2584	7	presence	presence	NN
cord-015021-pol2qm74	2584	8	of	of	IN
cord-015021-pol2qm74	2584	9	AFC	AFC	NNP
cord-015021-pol2qm74	2584	10	leads	lead	VBZ
cord-015021-pol2qm74	2584	11	to	to	IN
cord-015021-pol2qm74	2584	12	a	a	DT
cord-015021-pol2qm74	2584	13	decreased	decrease	VBN
cord-015021-pol2qm74	2584	14	NO	no	DT
cord-015021-pol2qm74	2584	15	2-accumulation	2-accumulation	CD
cord-015021-pol2qm74	2584	16	,	,	,
cord-015021-pol2qm74	2584	17	4.7	4.7	CD
cord-015021-pol2qm74	2584	18	nmole	nmole	NNP
cord-015021-pol2qm74	2584	19	/	/	SYM
cord-015021-pol2qm74	2584	20	well	well	RB
cord-015021-pol2qm74	2584	21	v.s.	v.s.	NNP
cord-015021-pol2qm74	2584	22	21	21	CD
cord-015021-pol2qm74	2584	23	nmole/	nmole/	ADD
cord-015021-pol2qm74	2585	1	well	well	UH
cord-015021-pol2qm74	2585	2	.	.	.
cord-015021-pol2qm74	2586	1	Conversely	conversely	RB
cord-015021-pol2qm74	2586	2	H202	h202	NN
cord-015021-pol2qm74	2586	3	production	production	NN
cord-015021-pol2qm74	2586	4	is	be	VBZ
cord-015021-pol2qm74	2586	5	enhanced	enhance	VBN
cord-015021-pol2qm74	2586	6	from	from	IN
cord-015021-pol2qm74	2586	7	09	09	CD
cord-015021-pol2qm74	2586	8	nmole/	nmole/	ADD
cord-015021-pol2qm74	2587	1	well	well	UH
cord-015021-pol2qm74	2587	2	up	up	IN
cord-015021-pol2qm74	2587	3	to	to	IN
cord-015021-pol2qm74	2587	4	2,33	2,33	CD
cord-015021-pol2qm74	2587	5	nmole/	nmole/	ADD
cord-015021-pol2qm74	2588	1	well	well	UH
cord-015021-pol2qm74	2588	2	.	.	.
cord-015021-pol2qm74	2589	1	Nevertheless	nevertheless	RB
cord-015021-pol2qm74	2589	2	,	,	,
cord-015021-pol2qm74	2589	3	macrophages	macrophage	NNS
cord-015021-pol2qm74	2589	4	cultivated	cultivate	VBN
cord-015021-pol2qm74	2589	5	in	in	IN
cord-015021-pol2qm74	2589	6	the	the	DT
cord-015021-pol2qm74	2589	7	presence	presence	NN
cord-015021-pol2qm74	2589	8	of	of	IN
cord-015021-pol2qm74	2589	9	AFC	AFC	NNP
cord-015021-pol2qm74	2589	10	exhibit	exhibit	VB
cord-015021-pol2qm74	2589	11	an	an	DT
cord-015021-pol2qm74	2589	12	increased	increase	VBN
cord-015021-pol2qm74	2589	13	tale	tale	NN
cord-015021-pol2qm74	2589	14	of	of	IN
cord-015021-pol2qm74	2589	15	intracellular	intracellular	JJ
cord-015021-pol2qm74	2589	16	killing	killing	NN
cord-015021-pol2qm74	2589	17	,	,	,
cord-015021-pol2qm74	2589	18	77	77	CD
cord-015021-pol2qm74	2589	19	%	%	NN
cord-015021-pol2qm74	2589	20	in	in	IN
cord-015021-pol2qm74	2589	21	iron	iron	NN
cord-015021-pol2qm74	2589	22	exposed	expose	VBN
cord-015021-pol2qm74	2589	23	macrophages	macrophage	NNS
cord-015021-pol2qm74	2589	24	v.s	v.s	NNP
cord-015021-pol2qm74	2589	25	,	,	,
cord-015021-pol2qm74	2589	26	68	68	CD
cord-015021-pol2qm74	2589	27	%	%	NN
cord-015021-pol2qm74	2589	28	in	in	IN
cord-015021-pol2qm74	2589	29	control	control	NN
cord-015021-pol2qm74	2589	30	macrophages	macrophage	NNS
cord-015021-pol2qm74	2589	31	.	.	.
cord-015021-pol2qm74	2590	1	When	when	WRB
cord-015021-pol2qm74	2590	2	triggered	trigger	VBN
cord-015021-pol2qm74	2590	3	with	with	IN
cord-015021-pol2qm74	2590	4	IFN-~	IFN-~	NNP
cord-015021-pol2qm74	2590	5	,	,	,
cord-015021-pol2qm74	2590	6	alone	alone	RB
cord-015021-pol2qm74	2590	7	,	,	,
cord-015021-pol2qm74	2590	8	macrophages	macrophage	NNS
cord-015021-pol2qm74	2590	9	have	have	VBP
cord-015021-pol2qm74	2590	10	a	a	DT
cord-015021-pol2qm74	2590	11	reduced	reduce	VBN
cord-015021-pol2qm74	2590	12	antibacterial	antibacterial	JJ
cord-015021-pol2qm74	2590	13	activity	activity	NN
cord-015021-pol2qm74	2590	14	(	(	-LRB-
cord-015021-pol2qm74	2590	15	57	57	CD
cord-015021-pol2qm74	2590	16	%	%	NN
cord-015021-pol2qm74	2590	17	v.s.	v.s.	NNP
cord-015021-pol2qm74	2590	18	68	68	CD
cord-015021-pol2qm74	2590	19	%	%	NN
cord-015021-pol2qm74	2590	20	)	)	-RRB-
cord-015021-pol2qm74	2590	21	whereas	whereas	IN
cord-015021-pol2qm74	2590	22	the	the	DT
cord-015021-pol2qm74	2590	23	addition	addition	NN
cord-015021-pol2qm74	2590	24	of	of	IN
cord-015021-pol2qm74	2590	25	AFC	AFC	NNP
cord-015021-pol2qm74	2590	26	to	to	IN
cord-015021-pol2qm74	2590	27	these	these	DT
cord-015021-pol2qm74	2590	28	macrophagas	macrophagas	NN
cord-015021-pol2qm74	2590	29	restores	restore	VBZ
cord-015021-pol2qm74	2590	30	an	an	DT
cord-015021-pol2qm74	2590	31	elevated	elevated	JJ
cord-015021-pol2qm74	2590	32	(	(	-LRB-
cord-015021-pol2qm74	2590	33	72	72	CD
cord-015021-pol2qm74	2590	34	%	%	NN
cord-015021-pol2qm74	2590	35	)	)	-RRB-
cord-015021-pol2qm74	2590	36	rate	rate	NN
cord-015021-pol2qm74	2590	37	of	of	IN
cord-015021-pol2qm74	2590	38	killing	killing	NN
cord-015021-pol2qm74	2590	39	.	.	.
cord-015021-pol2qm74	2591	1	In	in	IN
cord-015021-pol2qm74	2591	2	conclusion	conclusion	NN
cord-015021-pol2qm74	2591	3	,	,	,
cord-015021-pol2qm74	2591	4	the	the	DT
cord-015021-pol2qm74	2591	5	results	result	NNS
cord-015021-pol2qm74	2591	6	show	show	VBP
cord-015021-pol2qm74	2591	7	that	that	IN
cord-015021-pol2qm74	2591	8	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	2591	9	activity	activity	NN
cord-015021-pol2qm74	2591	10	of	of	IN
cord-015021-pol2qm74	2591	11	CBA	CBA	NNP
cord-015021-pol2qm74	2591	12	macrophages	macrophage	NNS
cord-015021-pol2qm74	2591	13	towards	towards	IN
cord-015021-pol2qm74	2591	14	S.typhimurium	s.typhimurium	NN
cord-015021-pol2qm74	2591	15	depends	depend	VBZ
cord-015021-pol2qm74	2591	16	on	on	IN
cord-015021-pol2qm74	2591	17	the	the	DT
cord-015021-pol2qm74	2591	18	production	production	NN
cord-015021-pol2qm74	2591	19	of	of	IN
cord-015021-pol2qm74	2591	20	NO	no	NN
cord-015021-pol2qm74	2591	21	by	by	IN
cord-015021-pol2qm74	2591	22	these	these	DT
cord-015021-pol2qm74	2591	23	macrophages	macrophage	NNS
cord-015021-pol2qm74	2591	24	;	;	:
cord-015021-pol2qm74	2591	25	but	but	CC
cord-015021-pol2qm74	2591	26	they	-PRON-	PRP
cord-015021-pol2qm74	2591	27	also	also	RB
cord-015021-pol2qm74	2591	28	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2591	29	that	that	IN
cord-015021-pol2qm74	2591	30	NO	no	NN
cord-015021-pol2qm74	2591	31	is	be	VBZ
cord-015021-pol2qm74	2591	32	not	not	RB
cord-015021-pol2qm74	2591	33	the	the	DT
cord-015021-pol2qm74	2591	34	only	only	JJ
cord-015021-pol2qm74	2591	35	reactive	reactive	JJ
cord-015021-pol2qm74	2591	36	species	specie	NNS
cord-015021-pol2qm74	2591	37	involved	involve	VBN
cord-015021-pol2qm74	2591	38	in	in	IN
cord-015021-pol2qm74	2591	39	the	the	DT
cord-015021-pol2qm74	2591	40	intracellular	intracellular	JJ
cord-015021-pol2qm74	2591	41	kil	kil	NN
cord-015021-pol2qm74	2591	42	/	/	SYM
cord-015021-pol2qm74	2591	43	ing	ing	NN
cord-015021-pol2qm74	2591	44	of	of	IN
cord-015021-pol2qm74	2591	45	S.thyphimurium	s.thyphimurium	NN
cord-015021-pol2qm74	2591	46	;	;	:
cord-015021-pol2qm74	2591	47	indeed	indeed	RB
cord-015021-pol2qm74	2591	48	AFC	AFC	NNP
cord-015021-pol2qm74	2591	49	which	which	WDT
cord-015021-pol2qm74	2591	50	strongly	strongly	RB
cord-015021-pol2qm74	2591	51	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2591	52	RNI	RNI	NNP
cord-015021-pol2qm74	2591	53	production	production	NN
cord-015021-pol2qm74	2591	54	,	,	,
cord-015021-pol2qm74	2591	55	stimulates	stimulate	VBZ
cord-015021-pol2qm74	2591	56	H20	H20	NNP
cord-015021-pol2qm74	2591	57	2	2	CD
cord-015021-pol2qm74	2591	58	release	release	NN
cord-015021-pol2qm74	2591	59	by	by	IN
cord-015021-pol2qm74	2591	60	these	these	DT
cord-015021-pol2qm74	2591	61	macrophages	macrophage	NNS
cord-015021-pol2qm74	2591	62	and	and	CC
cord-015021-pol2qm74	2591	63	increase	increase	VB
cord-015021-pol2qm74	2591	64	their	-PRON-	PRP$
cord-015021-pol2qm74	2591	65	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	2591	66	activity	activity	NN
cord-015021-pol2qm74	2591	67	in	in	IN
cord-015021-pol2qm74	2591	68	vitro	vitro	FW
cord-015021-pol2qm74	2591	69	.	.	.
cord-015021-pol2qm74	2592	1	Nevertheless	nevertheless	RB
cord-015021-pol2qm74	2592	2	AFC	AFC	NNP
cord-015021-pol2qm74	2592	3	may	may	MD
cord-015021-pol2qm74	2592	4	promote	promote	VB
cord-015021-pol2qm74	2592	5	bacterial	bacterial	JJ
cord-015021-pol2qm74	2592	6	growth	growth	NN
cord-015021-pol2qm74	2592	7	in	in	IN
cord-015021-pol2qm74	2592	8	vivo	vivo	NN
cord-015021-pol2qm74	2592	9	.	.	.
cord-015021-pol2qm74	2593	1	CRSSA	CRSSA	NNP
cord-015021-pol2qm74	2593	2	.	.	.
cord-015021-pol2qm74	2594	1	Unit4	Unit4	NNP
cord-015021-pol2qm74	2594	2	de	de	NNP
cord-015021-pol2qm74	2594	3	Microbiologie	Microbiologie	NNP
cord-015021-pol2qm74	2594	4	.	.	.
cord-015021-pol2qm74	2595	1	BP	BP	NNP
cord-015021-pol2qm74	2595	2	87	87	CD
cord-015021-pol2qm74	2595	3	.	.	.
cord-015021-pol2qm74	2596	1	38702	38702	CD
cord-015021-pol2qm74	2597	1	La	La	NNP
cord-015021-pol2qm74	2597	2	Tronche	Tronche	NNP
cord-015021-pol2qm74	2597	3	Cedex	Cedex	NNP
cord-015021-pol2qm74	2597	4	FRANCE	FRANCE	NNP
cord-015021-pol2qm74	2597	5	.	.	.
cord-015021-pol2qm74	2598	1	Henning	Henning	NNP
cord-015021-pol2qm74	2598	2	Jahr	Jahr	NNP
cord-015021-pol2qm74	2598	3	,	,	,
cord-015021-pol2qm74	2598	4	Ulrike	Ulrike	NNP
cord-015021-pol2qm74	2598	5	Noack	Noack	NNP
cord-015021-pol2qm74	2598	6	,	,	,
cord-015021-pol2qm74	2598	7	Karin	Karin	NNP
cord-015021-pol2qm74	2598	8	Braun	Braun	NNP
cord-015021-pol2qm74	2599	1	The	the	DT
cord-015021-pol2qm74	2599	2	large	large	JJ
cord-015021-pol2qm74	2599	3	amounts	amount	NNS
cord-015021-pol2qm74	2599	4	of	of	IN
cord-015021-pol2qm74	2599	5	NO	no	DT
cord-015021-pol2qm74	2599	6	produced	produce	VBN
cord-015021-pol2qm74	2599	7	by	by	IN
cord-015021-pol2qm74	2599	8	the	the	DT
cord-015021-pol2qm74	2599	9	inducible	inducible	JJ
cord-015021-pol2qm74	2599	10	NO	no	DT
cord-015021-pol2qm74	2599	11	synthase	synthase	NN
cord-015021-pol2qm74	2599	12	in	in	IN
cord-015021-pol2qm74	2599	13	rat	rat	NN
cord-015021-pol2qm74	2599	14	macrophages	macrophage	NNS
cord-015021-pol2qm74	2599	15	have	have	VBP
cord-015021-pol2qm74	2599	16	direct	direct	JJ
cord-015021-pol2qm74	2599	17	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	2599	18	effects	effect	NNS
cord-015021-pol2qm74	2599	19	,	,	,
cord-015021-pol2qm74	2599	20	but	but	CC
cord-015021-pol2qm74	2599	21	inhibit	inhibit	VB
cord-015021-pol2qm74	2599	22	the	the	DT
cord-015021-pol2qm74	2599	23	activation	activation	NN
cord-015021-pol2qm74	2599	24	of	of	IN
cord-015021-pol2qm74	2599	25	the	the	DT
cord-015021-pol2qm74	2599	26	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	2599	27	-	-	HYPH
cord-015021-pol2qm74	2599	28	dependent	dependent	JJ
cord-015021-pol2qm74	2599	29	host	host	NN
cord-015021-pol2qm74	2599	30	defense	defense	NN
cord-015021-pol2qm74	2599	31	system	system	NN
cord-015021-pol2qm74	2599	32	.	.	.
cord-015021-pol2qm74	2600	1	The	the	DT
cord-015021-pol2qm74	2600	2	aim	aim	NN
cord-015021-pol2qm74	2600	3	of	of	IN
cord-015021-pol2qm74	2600	4	this	this	DT
cord-015021-pol2qm74	2600	5	study	study	NN
cord-015021-pol2qm74	2600	6	was	be	VBD
cord-015021-pol2qm74	2600	7	to	to	TO
cord-015021-pol2qm74	2600	8	investigate	investigate	VB
cord-015021-pol2qm74	2600	9	if	if	IN
cord-015021-pol2qm74	2600	10	complement	complement	JJ
cord-015021-pol2qm74	2600	11	activation	activation	NN
cord-015021-pol2qm74	2600	12	influences	influence	NNS
cord-015021-pol2qm74	2600	13	NO	no	NN
cord-015021-pol2qm74	2600	14	-	-	HYPH
cord-015021-pol2qm74	2600	15	generation	generation	NN
cord-015021-pol2qm74	2600	16	.	.	.
cord-015021-pol2qm74	2601	1	Spleen	spleen	NN
cord-015021-pol2qm74	2601	2	cells	cell	NNS
cord-015021-pol2qm74	2601	3	from	from	IN
cord-015021-pol2qm74	2601	4	LEW	LEW	NNP
cord-015021-pol2qm74	2601	5	rats	rat	NNS
cord-015021-pol2qm74	2601	6	were	be	VBD
cord-015021-pol2qm74	2601	7	incubated	incubate	VBN
cord-015021-pol2qm74	2601	8	at	at	IN
cord-015021-pol2qm74	2601	9	37	37	CD
cord-015021-pol2qm74	2601	10	°	°	NNS
cord-015021-pol2qm74	2601	11	in	in	IN
cord-015021-pol2qm74	2601	12	TCM-199/5	TCM-199/5	NNP
cord-015021-pol2qm74	2601	13	%	%	NN
cord-015021-pol2qm74	2601	14	FCS	FCS	NNP
cord-015021-pol2qm74	2601	15	,	,	,
cord-015021-pol2qm74	2601	16	with	with	IN
cord-015021-pol2qm74	2601	17	or	or	CC
cord-015021-pol2qm74	2601	18	without	without	IN
cord-015021-pol2qm74	2601	19	additional	additional	JJ
cord-015021-pol2qm74	2601	20	rat	rat	NN
cord-015021-pol2qm74	2601	21	serum	serum	NN
cord-015021-pol2qm74	2601	22	.	.	.
cord-015021-pol2qm74	2602	1	After	after	IN
cord-015021-pol2qm74	2602	2	20	20	CD
cord-015021-pol2qm74	2602	3	h	h	NN
cord-015021-pol2qm74	2602	4	,	,	,
cord-015021-pol2qm74	2602	5	nitrite	nitrite	NN
cord-015021-pol2qm74	2602	6	(	(	-LRB-
cord-015021-pol2qm74	2602	7	end	end	NN
cord-015021-pol2qm74	2602	8	product	product	NN
cord-015021-pol2qm74	2602	9	from	from	IN
cord-015021-pol2qm74	2602	10	NO	no	DT
cord-015021-pol2qm74	2602	11	metabolism	metabolism	NN
cord-015021-pol2qm74	2602	12	)	)	-RRB-
cord-015021-pol2qm74	2602	13	was	be	VBD
cord-015021-pol2qm74	2602	14	measured	measure	VBN
cord-015021-pol2qm74	2602	15	by	by	IN
cord-015021-pol2qm74	2602	16	Oriess	Oriess	NNP
cord-015021-pol2qm74	2602	17	reagent	reagent	NN
cord-015021-pol2qm74	2602	18	.	.	.
cord-015021-pol2qm74	2603	1	In	in	IN
cord-015021-pol2qm74	2603	2	rat	rat	NN
cord-015021-pol2qm74	2603	3	spleen	spleen	NN
cord-015021-pol2qm74	2603	4	cell	cell	NN
cord-015021-pol2qm74	2603	5	preparations	preparation	NNS
cord-015021-pol2qm74	2603	6	,	,	,
cord-015021-pol2qm74	2603	7	most	most	JJS
cord-015021-pol2qm74	2603	8	of	of	IN
cord-015021-pol2qm74	2603	9	the	the	DT
cord-015021-pol2qm74	2603	10	NO	no	NN
cord-015021-pol2qm74	2603	11	is	be	VBZ
cord-015021-pol2qm74	2603	12	produced	produce	VBN
cord-015021-pol2qm74	2603	13	by	by	IN
cord-015021-pol2qm74	2603	14	macrophages	macrophage	NNS
cord-015021-pol2qm74	2603	15	.	.	.
cord-015021-pol2qm74	2604	1	Complement	complement	JJ
cord-015021-pol2qm74	2604	2	activation	activation	NN
cord-015021-pol2qm74	2604	3	in	in	IN
cord-015021-pol2qm74	2604	4	vivo	vivo	NN
cord-015021-pol2qm74	2604	5	was	be	VBD
cord-015021-pol2qm74	2604	6	carried	carry	VBN
cord-015021-pol2qm74	2604	7	out	out	RP
cord-015021-pol2qm74	2604	8	by	by	IN
cord-015021-pol2qm74	2604	9	i.v	i.v	NNP
cord-015021-pol2qm74	2604	10	.	.	.
cord-015021-pol2qm74	2604	11	injections	injection	NNS
cord-015021-pol2qm74	2604	12	of	of	IN
cord-015021-pol2qm74	2604	13	240	240	CD
cord-015021-pol2qm74	2604	14	U	U	NNP
cord-015021-pol2qm74	2604	15	cobra	cobra	NN
cord-015021-pol2qm74	2604	16	venom	venom	NN
cord-015021-pol2qm74	2604	17	factor	factor	NN
cord-015021-pol2qm74	2604	18	/	/	SYM
cord-015021-pol2qm74	2604	19	kg	kg	NN
cord-015021-pol2qm74	2604	20	b.w	b.w	NNP
cord-015021-pol2qm74	2604	21	.	.	.
cord-015021-pol2qm74	2605	1	at	at	IN
cord-015021-pol2qm74	2605	2	days	day	NNS
cord-015021-pol2qm74	2605	3	0	0	CD
cord-015021-pol2qm74	2605	4	and	and	CC
cord-015021-pol2qm74	2605	5	2	2	CD
cord-015021-pol2qm74	2605	6	.	.	.
cord-015021-pol2qm74	2606	1	Significantly	significantly	RB
cord-015021-pol2qm74	2606	2	higher	high	JJR
cord-015021-pol2qm74	2607	1	(	(	-LRB-
cord-015021-pol2qm74	2607	2	P	p	NN
cord-015021-pol2qm74	2607	3	<	<	XX
cord-015021-pol2qm74	2607	4	O.O1	o.o1	NN
cord-015021-pol2qm74	2607	5	)	)	-RRB-
cord-015021-pol2qm74	2607	6	LPS	lps	NN
cord-015021-pol2qm74	2607	7	-	-	HYPH
cord-015021-pol2qm74	2607	8	stimulated	stimulate	VBN
cord-015021-pol2qm74	2607	9	NO	no	NN
cord-015021-pol2qm74	2607	10	-	-	HYPH
cord-015021-pol2qm74	2607	11	generation	generation	NN
cord-015021-pol2qm74	2607	12	was	be	VBD
cord-015021-pol2qm74	2607	13	found	find	VBN
cord-015021-pol2qm74	2607	14	in	in	IN
cord-015021-pol2qm74	2607	15	spleen	spleen	NN
cord-015021-pol2qm74	2607	16	cells	cell	NNS
cord-015021-pol2qm74	2607	17	prepared	prepare	VBN
cord-015021-pol2qm74	2607	18	at	at	IN
cord-015021-pol2qm74	2607	19	day	day	NN
cord-015021-pol2qm74	2607	20	4	4	CD
cord-015021-pol2qm74	2607	21	(	(	-LRB-
cord-015021-pol2qm74	2607	22	13.0	13.0	CD
cord-015021-pol2qm74	2607	23	4	4	CD
cord-015021-pol2qm74	2607	24	-	-	SYM
cord-015021-pol2qm74	2607	25	1.3	1.3	CD
cord-015021-pol2qm74	2607	26	nmol	nmol	NN
cord-015021-pol2qm74	2607	27	nitrite/106	nitrite/106	NNP
cord-015021-pol2qm74	2607	28	cells	cell	NNS
cord-015021-pol2qm74	2607	29	,	,	,
cord-015021-pol2qm74	2607	30	n=6	n=6	JJ
cord-015021-pol2qm74	2607	31	)	)	-RRB-
cord-015021-pol2qm74	2607	32	compared	compare	VBN
cord-015021-pol2qm74	2607	33	to	to	IN
cord-015021-pol2qm74	2607	34	spleen	spleen	NN
cord-015021-pol2qm74	2607	35	cells	cell	NNS
cord-015021-pol2qm74	2607	36	from	from	IN
cord-015021-pol2qm74	2607	37	non	non	JJ
cord-015021-pol2qm74	2607	38	-	-	JJ
cord-015021-pol2qm74	2607	39	treated	treat	VBN
cord-015021-pol2qm74	2607	40	animals	animal	NNS
cord-015021-pol2qm74	2607	41	(	(	-LRB-
cord-015021-pol2qm74	2607	42	3.6	3.6	CD
cord-015021-pol2qm74	2607	43	±	±	CD
cord-015021-pol2qm74	2607	44	1.3	1.3	CD
cord-015021-pol2qm74	2607	45	nmol	nmol	NN
cord-015021-pol2qm74	2607	46	,	,	,
cord-015021-pol2qm74	2607	47	n=6	n=6	JJ
cord-015021-pol2qm74	2607	48	)	)	-RRB-
cord-015021-pol2qm74	2608	1	Complement	complement	JJ
cord-015021-pol2qm74	2608	2	activation	activation	NN
cord-015021-pol2qm74	2608	3	was	be	VBD
cord-015021-pol2qm74	2608	4	effective	effective	JJ
cord-015021-pol2qm74	2608	5	also	also	RB
cord-015021-pol2qm74	2608	6	in	in	IN
cord-015021-pol2qm74	2608	7	vitro	vitro	FW
cord-015021-pol2qm74	2608	8	.	.	.
cord-015021-pol2qm74	2609	1	When	when	WRB
cord-015021-pol2qm74	2609	2	incubated	incubate	VBN
cord-015021-pol2qm74	2609	3	in	in	IN
cord-015021-pol2qm74	2609	4	25	25	CD
cord-015021-pol2qm74	2609	5	%	%	NN
cord-015021-pol2qm74	2609	6	zymosan	zymosan	NNP
cord-015021-pol2qm74	2609	7	-	-	HYPH
cord-015021-pol2qm74	2609	8	activated	activate	VBN
cord-015021-pol2qm74	2609	9	rat	rat	NN
cord-015021-pol2qm74	2609	10	serum	serum	NN
cord-015021-pol2qm74	2609	11	,	,	,
cord-015021-pol2qm74	2609	12	both	both	CC
cord-015021-pol2qm74	2609	13	basal	basal	NN
cord-015021-pol2qm74	2609	14	and	and	CC
cord-015021-pol2qm74	2609	15	LPS	LPS	NNP
cord-015021-pol2qm74	2609	16	-	-	HYPH
cord-015021-pol2qm74	2609	17	stimulated	stimulate	VBN
cord-015021-pol2qm74	2609	18	NOproduction	NOproduction	NNP
cord-015021-pol2qm74	2609	19	were	be	VBD
cord-015021-pol2qm74	2609	20	enhanced	enhance	VBN
cord-015021-pol2qm74	2609	21	in	in	IN
cord-015021-pol2qm74	2609	22	spleen	spleen	NN
cord-015021-pol2qm74	2609	23	cells	cell	NNS
cord-015021-pol2qm74	2609	24	(	(	-LRB-
cord-015021-pol2qm74	2609	25	Table	table	NN
cord-015021-pol2qm74	2609	26	,	,	,
cord-015021-pol2qm74	2609	27	values	value	NNS
cord-015021-pol2qm74	2609	28	Increased	increase	VBN
cord-015021-pol2qm74	2609	29	production	production	NN
cord-015021-pol2qm74	2609	30	of	of	IN
cord-015021-pol2qm74	2609	31	Nitric	nitric	NN
cord-015021-pol2qm74	2609	32	Oxide	oxide	NN
cord-015021-pol2qm74	2610	1	(	(	-LRB-
cord-015021-pol2qm74	2610	2	NO	no	UH
cord-015021-pol2qm74	2610	3	)	)	-RRB-
cord-015021-pol2qm74	2610	4	is	be	VBZ
cord-015021-pol2qm74	2610	5	associated	associate	VBN
cord-015021-pol2qm74	2610	6	with	with	IN
cord-015021-pol2qm74	2610	7	sepsis	sepsis	NN
cord-015021-pol2qm74	2610	8	,	,	,
cord-015021-pol2qm74	2610	9	however	however	RB
cord-015021-pol2qm74	2610	10	,	,	,
cord-015021-pol2qm74	2610	11	the	the	DT
cord-015021-pol2qm74	2610	12	effect	effect	NN
cord-015021-pol2qm74	2610	13	of	of	IN
cord-015021-pol2qm74	2610	14	NO	no	DT
cord-015021-pol2qm74	2610	15	inhibition	inhibition	NN
cord-015021-pol2qm74	2610	16	on	on	IN
cord-015021-pol2qm74	2610	17	survival	survival	NN
cord-015021-pol2qm74	2610	18	during	during	IN
cord-015021-pol2qm74	2610	19	sepsis	sepsis	NN
cord-015021-pol2qm74	2610	20	is	be	VBZ
cord-015021-pol2qm74	2610	21	unclear	unclear	JJ
cord-015021-pol2qm74	2610	22	.	.	.
cord-015021-pol2qm74	2611	1	We	-PRON-	PRP
cord-015021-pol2qm74	2611	2	examined	examine	VBD
cord-015021-pol2qm74	2611	3	the	the	DT
cord-015021-pol2qm74	2611	4	effect	effect	NN
cord-015021-pol2qm74	2611	5	of	of	IN
cord-015021-pol2qm74	2611	6	NO	no	DT
cord-015021-pol2qm74	2611	7	inhibition	inhibition	NN
cord-015021-pol2qm74	2611	8	on	on	IN
cord-015021-pol2qm74	2611	9	host	host	NN
cord-015021-pol2qm74	2611	10	's	's	POS
cord-015021-pol2qm74	2611	11	ability	ability	NN
cord-015021-pol2qm74	2611	12	to	to	TO
cord-015021-pol2qm74	2611	13	eliminate	eliminate	VB
cord-015021-pol2qm74	2611	14	bacteria	bacteria	NNS
cord-015021-pol2qm74	2611	15	and	and	CC
cord-015021-pol2qm74	2611	16	survival	survival	NN
cord-015021-pol2qm74	2611	17	in	in	IN
cord-015021-pol2qm74	2611	18	mice	mouse	NNS
cord-015021-pol2qm74	2611	19	sepsis	sepsis	NN
cord-015021-pol2qm74	2611	20	model	model	NN
cord-015021-pol2qm74	2611	21	.	.	.
cord-015021-pol2qm74	2612	1	Sixty	sixty	CD
cord-015021-pol2qm74	2612	2	female	female	NN
cord-015021-pol2qm74	2612	3	Balb	Balb	NNP
cord-015021-pol2qm74	2612	4	/	/	SYM
cord-015021-pol2qm74	2612	5	c	c	NN
cord-015021-pol2qm74	2612	6	mice	mouse	NNS
cord-015021-pol2qm74	2612	7	were	be	VBD
cord-015021-pol2qm74	2612	8	injected	inject	VBN
cord-015021-pol2qm74	2612	9	with	with	IN
cord-015021-pol2qm74	2612	10	E.coli	E.coli	NNS
cord-015021-pol2qm74	2612	11	(	(	-LRB-
cord-015021-pol2qm74	2612	12	10qbody	10qbody	CD
cord-015021-pol2qm74	2612	13	)	)	-RRB-
cord-015021-pol2qm74	2612	14	into	into	IN
cord-015021-pol2qm74	2612	15	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	2612	16	cavity	cavity	NN
cord-015021-pol2qm74	2612	17	.	.	.
cord-015021-pol2qm74	2613	1	The	the	DT
cord-015021-pol2qm74	2613	2	treated	treated	JJ
cord-015021-pol2qm74	2613	3	group	group	NN
cord-015021-pol2qm74	2613	4	received	receive	VBD
cord-015021-pol2qm74	2613	5	N	N	NNP
cord-015021-pol2qm74	2613	6	-	-	HYPH
cord-015021-pol2qm74	2613	7	ultro	ultro	NNP
cord-015021-pol2qm74	2613	8	-	-	HYPH
cord-015021-pol2qm74	2613	9	l	l	NN
cord-015021-pol2qm74	2613	10	-	-	HYPH
cord-015021-pol2qm74	2613	11	arginine	arginine	NN
cord-015021-pol2qm74	2613	12	-	-	HYPH
cord-015021-pol2qm74	2613	13	methyl	methyl	NN
cord-015021-pol2qm74	2613	14	-	-	HYPH
cord-015021-pol2qm74	2613	15	ester	ester	NN
cord-015021-pol2qm74	2613	16	(	(	-LRB-
cord-015021-pol2qm74	2613	17	L	l	NN
cord-015021-pol2qm74	2613	18	-	-	HYPH
cord-015021-pol2qm74	2613	19	NAME	NAME	NNP
cord-015021-pol2qm74	2613	20	)	)	-RRB-
cord-015021-pol2qm74	2613	21	,	,	,
cord-015021-pol2qm74	2613	22	an	an	DT
cord-015021-pol2qm74	2613	23	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2613	24	of	of	IN
cord-015021-pol2qm74	2613	25	NOS	NOS	NNP
cord-015021-pol2qm74	2613	26	,	,	,
cord-015021-pol2qm74	2613	27	one	one	CD
cord-015021-pol2qm74	2613	28	hour	hour	NN
cord-015021-pol2qm74	2613	29	before	before	IN
cord-015021-pol2qm74	2613	30	bacterial	bacterial	JJ
cord-015021-pol2qm74	2613	31	challenge	challenge	NN
cord-015021-pol2qm74	2613	32	.	.	.
cord-015021-pol2qm74	2614	1	Thirty	thirty	CD
cord-015021-pol2qm74	2614	2	mice	mouse	NNS
cord-015021-pol2qm74	2614	3	were	be	VBD
cord-015021-pol2qm74	2614	4	observed	observe	VBN
cord-015021-pol2qm74	2614	5	for	for	IN
cord-015021-pol2qm74	2614	6	survival	survival	NN
cord-015021-pol2qm74	2614	7	after	after	IN
cord-015021-pol2qm74	2614	8	E.coli	e.coli	NN
cord-015021-pol2qm74	2614	9	challenge	challenge	NN
cord-015021-pol2qm74	2614	10	and	and	CC
cord-015021-pol2qm74	2614	11	the	the	DT
cord-015021-pol2qm74	2614	12	other	other	JJ
cord-015021-pol2qm74	2614	13	mice	mouse	NNS
cord-015021-pol2qm74	2614	14	were	be	VBD
cord-015021-pol2qm74	2614	15	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	2614	16	at	at	IN
cord-015021-pol2qm74	2614	17	4	4	CD
cord-015021-pol2qm74	2614	18	hours	hour	NNS
cord-015021-pol2qm74	2614	19	.	.	.
cord-015021-pol2qm74	2615	1	Blood	blood	NN
cord-015021-pol2qm74	2615	2	was	be	VBD
cord-015021-pol2qm74	2615	3	obtained	obtain	VBN
cord-015021-pol2qm74	2615	4	by	by	IN
cord-015021-pol2qm74	2615	5	cardiac	cardiac	JJ
cord-015021-pol2qm74	2615	6	puncture	puncture	NN
cord-015021-pol2qm74	2615	7	and	and	CC
cord-015021-pol2qm74	2615	8	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	2615	9	lavage	lavage	NN
cord-015021-pol2qm74	2615	10	fluid	fluid	NN
cord-015021-pol2qm74	2615	11	(	(	-LRB-
cord-015021-pol2qm74	2615	12	PLF	PLF	NNP
cord-015021-pol2qm74	2615	13	)	)	-RRB-
cord-015021-pol2qm74	2615	14	,	,	,
cord-015021-pol2qm74	2615	15	liver	liver	NN
cord-015021-pol2qm74	2615	16	and	and	CC
cord-015021-pol2qm74	2615	17	lung	lung	NN
cord-015021-pol2qm74	2615	18	were	be	VBD
cord-015021-pol2qm74	2615	19	harvested	harvest	VBN
cord-015021-pol2qm74	2615	20	.	.	.
cord-015021-pol2qm74	2616	1	The	the	DT
cord-015021-pol2qm74	2616	2	number	number	NN
cord-015021-pol2qm74	2616	3	of	of	IN
cord-015021-pol2qm74	2616	4	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	2616	5	exudative	exudative	JJ
cord-015021-pol2qm74	2616	6	cell	cell	NN
cord-015021-pol2qm74	2616	7	(	(	-LRB-
cord-015021-pol2qm74	2616	8	PEC	PEC	NNP
cord-015021-pol2qm74	2616	9	)	)	-RRB-
cord-015021-pol2qm74	2616	10	was	be	VBD
cord-015021-pol2qm74	2616	11	counted	count	VBN
cord-015021-pol2qm74	2616	12	and	and	CC
cord-015021-pol2qm74	2616	13	colony	colony	NN
cord-015021-pol2qm74	2616	14	forming	form	VBG
cord-015021-pol2qm74	2616	15	units	unit	NNS
cord-015021-pol2qm74	2616	16	(	(	-LRB-
cord-015021-pol2qm74	2616	17	CFLD	CFLD	NNP
cord-015021-pol2qm74	2616	18	of	of	IN
cord-015021-pol2qm74	2616	19	bacteria	bacteria	NNS
cord-015021-pol2qm74	2616	20	in	in	IN
cord-015021-pol2qm74	2616	21	the	the	DT
cord-015021-pol2qm74	2616	22	tissues	tissue	NNS
cord-015021-pol2qm74	2616	23	,	,	,
cord-015021-pol2qm74	2616	24	blood	blood	NN
cord-015021-pol2qm74	2616	25	,	,	,
cord-015021-pol2qm74	2616	26	and	and	CC
cord-015021-pol2qm74	2616	27	PLF	PLF	NNP
cord-015021-pol2qm74	2616	28	were	be	VBD
cord-015021-pol2qm74	2616	29	also	also	RB
cord-015021-pol2qm74	2616	30	determined	determine	VBN
cord-015021-pol2qm74	2616	31	.	.	.
cord-015021-pol2qm74	2617	1	In	in	IN
cord-015021-pol2qm74	2617	2	addition	addition	NN
cord-015021-pol2qm74	2617	3	,	,	,
cord-015021-pol2qm74	2617	4	PEC	PEC	NNP
cord-015021-pol2qm74	2617	5	was	be	VBD
cord-015021-pol2qm74	2617	6	cultured	culture	VBN
cord-015021-pol2qm74	2617	7	in	in	IN
cord-015021-pol2qm74	2617	8	vitro	vitro	FW
cord-015021-pol2qm74	2617	9	with	with	IN
cord-015021-pol2qm74	2617	10	or	or	CC
cord-015021-pol2qm74	2617	11	without	without	IN
cord-015021-pol2qm74	2617	12	lipopolysaecharide	lipopolysaecharide	NN
cord-015021-pol2qm74	2617	13	(	(	-LRB-
cord-015021-pol2qm74	2617	14	LPS	LPS	NNP
cord-015021-pol2qm74	2617	15	)	)	-RRB-
cord-015021-pol2qm74	2617	16	.	.	.
cord-015021-pol2qm74	2618	1	TNF	TNF	NNP
cord-015021-pol2qm74	2618	2	levels	level	NNS
cord-015021-pol2qm74	2618	3	in	in	IN
cord-015021-pol2qm74	2618	4	the	the	DT
cord-015021-pol2qm74	2618	5	blood	blood	NN
cord-015021-pol2qm74	2618	6	,	,	,
cord-015021-pol2qm74	2618	7	PLF	PLF	NNP
cord-015021-pol2qm74	2618	8	,	,	,
cord-015021-pol2qm74	2618	9	and	and	CC
cord-015021-pol2qm74	2618	10	supematants	supematant	NNS
cord-015021-pol2qm74	2618	11	of	of	IN
cord-015021-pol2qm74	2618	12	cultured	cultured	JJ
cord-015021-pol2qm74	2618	13	PEC	PEC	NNP
cord-015021-pol2qm74	2618	14	were	be	VBD
cord-015021-pol2qm74	2618	15	measured	measure	VBN
cord-015021-pol2qm74	2618	16	by	by	IN
cord-015021-pol2qm74	2618	17	L929	l929	CD
cord-015021-pol2qm74	2618	18	bioassay	bioassay	NN
cord-015021-pol2qm74	2618	19	.	.	.
cord-015021-pol2qm74	2619	1	Survival	survival	NN
cord-015021-pol2qm74	2619	2	Rate	rate	NN
cord-015021-pol2qm74	2619	3	(	(	-LRB-
cord-015021-pol2qm74	2619	4	%	%	NN
cord-015021-pol2qm74	2619	5	)	)	-RRB-
cord-015021-pol2qm74	2620	1	Qrql/,p	Qrql/,p	NNP
cord-015021-pol2qm74	2620	2	n	n	NN
cord-015021-pol2qm74	2620	3	8	8	CD
cord-015021-pol2qm74	2620	4	hr	hr	NN
cord-015021-pol2qm74	2620	5	24	24	CD
cord-015021-pol2qm74	2620	6	hr	hr	NN
cord-015021-pol2qm74	2620	7	4	4	CD
cord-015021-pol2qm74	2620	8	dav	dav	NN
cord-015021-pol2qm74	2620	9	control	control	NN
cord-015021-pol2qm74	2620	10	(	(	-LRB-
cord-015021-pol2qm74	2620	11	normal	normal	JJ
cord-015021-pol2qm74	2620	12	saline	saline	NN
cord-015021-pol2qm74	2620	13	0.1ml	0.1ml	CD
cord-015021-pol2qm74	2620	14	/	/	SYM
cord-015021-pol2qm74	2620	15	body	body	NN
cord-015021-pol2qm74	2620	16	i.p	i.p	NNP
cord-015021-pol2qm74	2620	17	.	.	NNP
cord-015021-pol2qm74	2620	18	)	)	-RRB-
cord-015021-pol2qm74	2620	19	10	10	CD
cord-015021-pol2qm74	2620	20	100	100	CD
cord-015021-pol2qm74	2621	1	50	50	CD
cord-015021-pol2qm74	2621	2	40	40	CD
cord-015021-pol2qm74	2621	3	N10	N10	NNP
cord-015021-pol2qm74	2621	4	(	(	-LRB-
cord-015021-pol2qm74	2621	5	L	L	NNP
cord-015021-pol2qm74	2621	6	-	-	HYPH
cord-015021-pol2qm74	2621	7	NAME	NAME	NNP
cord-015021-pol2qm74	2621	8	10mg	10mg	NNP
cord-015021-pol2qm74	2621	9	/	/	SYM
cord-015021-pol2qm74	2621	10	kg	kg	NNP
cord-015021-pol2qm74	2621	11	i.	i.	NNP
cord-015021-pol2qm74	2621	12	Administration	Administration	NNP
cord-015021-pol2qm74	2621	13	of	of	IN
cord-015021-pol2qm74	2621	14	L	L	NNP
cord-015021-pol2qm74	2621	15	-	-	HYPH
cord-015021-pol2qm74	2621	16	NAME	name	NN
cord-015021-pol2qm74	2621	17	before	before	IN
cord-015021-pol2qm74	2621	18	E.coli	E.coli	NNS
cord-015021-pol2qm74	2621	19	injection	injection	NN
cord-015021-pol2qm74	2621	20	increased	increase	VBD
cord-015021-pol2qm74	2621	21	the	the	DT
cord-015021-pol2qm74	2621	22	number	number	NN
cord-015021-pol2qm74	2621	23	of	of	IN
cord-015021-pol2qm74	2621	24	bacteria	bacteria	NNS
cord-015021-pol2qm74	2621	25	in	in	IN
cord-015021-pol2qm74	2621	26	PLF	PLF	NNP
cord-015021-pol2qm74	2621	27	and	and	CC
cord-015021-pol2qm74	2621	28	TNF	TNF	NNP
cord-015021-pol2qm74	2621	29	level	level	NN
cord-015021-pol2qm74	2621	30	in	in	IN
cord-015021-pol2qm74	2621	31	plasma	plasma	NN
cord-015021-pol2qm74	2621	32	,	,	,
cord-015021-pol2qm74	2621	33	The	the	DT
cord-015021-pol2qm74	2621	34	result	result	NN
cord-015021-pol2qm74	2621	35	suggests	suggest	VBZ
cord-015021-pol2qm74	2621	36	that	that	IN
cord-015021-pol2qm74	2621	37	NOS	NOS	NNP
cord-015021-pol2qm74	2621	38	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2621	39	may	may	MD
cord-015021-pol2qm74	2621	40	depress	depress	VB
cord-015021-pol2qm74	2621	41	the	the	DT
cord-015021-pol2qm74	2621	42	host	host	NN
cord-015021-pol2qm74	2621	43	's	's	POS
cord-015021-pol2qm74	2621	44	ability	ability	NN
cord-015021-pol2qm74	2621	45	to	to	TO
cord-015021-pol2qm74	2621	46	kill	kill	VB
cord-015021-pol2qm74	2621	47	the	the	DT
cord-015021-pol2qm74	2621	48	injected	inject	VBN
cord-015021-pol2qm74	2621	49	bacteria	bacteria	NNS
cord-015021-pol2qm74	2621	50	and	and	CC
cord-015021-pol2qm74	2621	51	that	that	IN
cord-015021-pol2qm74	2621	52	it	-PRON-	PRP
cord-015021-pol2qm74	2621	53	may	may	MD
cord-015021-pol2qm74	2621	54	induce	induce	VB
cord-015021-pol2qm74	2621	55	greater	great	JJR
cord-015021-pol2qm74	2621	56	systemic	systemic	JJ
cord-015021-pol2qm74	2621	57	TNF	tnf	NN
cord-015021-pol2qm74	2621	58	production	production	NN
cord-015021-pol2qm74	2621	59	.	.	.
cord-015021-pol2qm74	2622	1	We	-PRON-	PRP
cord-015021-pol2qm74	2622	2	conclude	conclude	VBP
cord-015021-pol2qm74	2622	3	that	that	IN
cord-015021-pol2qm74	2622	4	NOS	NOS	NNP
cord-015021-pol2qm74	2622	5	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2622	6	is	be	VBZ
cord-015021-pol2qm74	2622	7	detrimental	detrimental	JJ
cord-015021-pol2qm74	2622	8	to	to	IN
cord-015021-pol2qm74	2622	9	animals	animal	NNS
cord-015021-pol2qm74	2622	10	in	in	IN
cord-015021-pol2qm74	2622	11	sepsis	sepsis	NN
cord-015021-pol2qm74	2622	12	.	.	.
cord-015021-pol2qm74	2623	1	The	the	DT
cord-015021-pol2qm74	2623	2	hypothesis	hypothesis	NN
cord-015021-pol2qm74	2623	3	that	that	IN
cord-015021-pol2qm74	2623	4	SOD	SOD	NNP
cord-015021-pol2qm74	2623	5	prevents	prevent	VBZ
cord-015021-pol2qm74	2623	6	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2623	7	injury	injury	NN
cord-015021-pol2qm74	2623	8	to	to	IN
cord-015021-pol2qm74	2623	9	the	the	DT
cord-015021-pol2qm74	2623	10	liver	liver	NN
cord-015021-pol2qm74	2623	11	by	by	IN
cord-015021-pol2qm74	2623	12	protecting	protect	VBG
cord-015021-pol2qm74	2623	13	the	the	DT
cord-015021-pol2qm74	2623	14	endogenous	endogenous	JJ
cord-015021-pol2qm74	2623	15	endothelium	endothelium	NN
cord-015021-pol2qm74	2623	16	derived	derive	VBN
cord-015021-pol2qm74	2623	17	vascular	vascular	JJ
cord-015021-pol2qm74	2623	18	relaxing	relaxing	JJ
cord-015021-pol2qm74	2623	19	factor	factor	NN
cord-015021-pol2qm74	2623	20	(	(	-LRB-
cord-015021-pol2qm74	2623	21	NO	no	UH
cord-015021-pol2qm74	2623	22	)	)	-RRB-
cord-015021-pol2qm74	2623	23	from	from	IN
cord-015021-pol2qm74	2623	24	being	be	VBG
cord-015021-pol2qm74	2623	25	inactivated	inactivate	VBN
cord-015021-pol2qm74	2623	26	by	by	IN
cord-015021-pol2qm74	2623	27	oxygen	oxygen	NN
cord-015021-pol2qm74	2623	28	free	free	JJ
cord-015021-pol2qm74	2623	29	radicals	radical	NNS
cord-015021-pol2qm74	2623	30	should	should	MD
cord-015021-pol2qm74	2623	31	be	be	VB
cord-015021-pol2qm74	2623	32	investigated	investigate	VBN
cord-015021-pol2qm74	2623	33	.	.	.
cord-015021-pol2qm74	2624	1	Male	male	JJ
cord-015021-pol2qm74	2624	2	Wistar	Wistar	NNP
cord-015021-pol2qm74	2624	3	rats	rat	NNS
cord-015021-pol2qm74	2624	4	were	be	VBD
cord-015021-pol2qm74	2624	5	subjected	subject	VBN
cord-015021-pol2qm74	2624	6	to	to	IN
cord-015021-pol2qm74	2624	7	60	60	CD
cord-015021-pol2qm74	2624	8	min	min	NN
cord-015021-pol2qm74	2624	9	of	of	IN
cord-015021-pol2qm74	2624	10	partial	partial	JJ
cord-015021-pol2qm74	2624	11	liver	liver	NN
cord-015021-pol2qm74	2624	12	ischemia	ischemia	NN
cord-015021-pol2qm74	2624	13	(	(	-LRB-
cord-015021-pol2qm74	2624	14	70	70	CD
cord-015021-pol2qm74	2624	15	%	%	NN
cord-015021-pol2qm74	2624	16	)	)	-RRB-
cord-015021-pol2qm74	2624	17	and	and	CC
cord-015021-pol2qm74	2624	18	30	30	CD
cord-015021-pol2qm74	2624	19	min	min	NN
cord-015021-pol2qm74	2624	20	of	of	IN
cord-015021-pol2qm74	2624	21	consecutive	consecutive	JJ
cord-015021-pol2qm74	2624	22	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2624	23	in	in	IN
cord-015021-pol2qm74	2624	24	situ	situ	NN
cord-015021-pol2qm74	2624	25	.	.	.
cord-015021-pol2qm74	2625	1	Some	some	DT
cord-015021-pol2qm74	2625	2	rats	rat	NNS
cord-015021-pol2qm74	2625	3	were	be	VBD
cord-015021-pol2qm74	2625	4	pretreated	pretreate	VBN
cord-015021-pol2qm74	2625	5	with	with	IN
cord-015021-pol2qm74	2625	6	the	the	DT
cord-015021-pol2qm74	2625	7	NO	no	DT
cord-015021-pol2qm74	2625	8	synthase	synthase	NN
cord-015021-pol2qm74	2625	9	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2625	10	nitro	nitro	NN
cord-015021-pol2qm74	2625	11	-	-	HYPH
cord-015021-pol2qm74	2625	12	L	L	NNP
cord-015021-pol2qm74	2625	13	-	-	HYPH
cord-015021-pol2qm74	2625	14	Arginin	Arginin	NNP
cord-015021-pol2qm74	2625	15	(	(	-LRB-
cord-015021-pol2qm74	2625	16	NLA	NLA	NNP
cord-015021-pol2qm74	2625	17	:	:	:
cord-015021-pol2qm74	2625	18	I0	I0	NNP
cord-015021-pol2qm74	2625	19	mg	mg	NNP
cord-015021-pol2qm74	2625	20	/	/	SYM
cord-015021-pol2qm74	2625	21	kg	kg	NNP
cord-015021-pol2qm74	2625	22	)	)	-RRB-
cord-015021-pol2qm74	2625	23	.	.	.
cord-015021-pol2qm74	2626	1	SOD	SOD	NNP
cord-015021-pol2qm74	2626	2	,	,	,
cord-015021-pol2qm74	2626	3	when	when	WRB
cord-015021-pol2qm74	2626	4	used	use	VBN
cord-015021-pol2qm74	2626	5	,	,	,
cord-015021-pol2qm74	2626	6	was	be	VBD
cord-015021-pol2qm74	2626	7	given	give	VBN
cord-015021-pol2qm74	2626	8	as	as	IN
cord-015021-pol2qm74	2626	9	Mn	Mn	NNP
cord-015021-pol2qm74	2626	10	-	-	HYPH
cord-015021-pol2qm74	2626	11	containing	contain	VBG
cord-015021-pol2qm74	2626	12	preparation	preparation	NN
cord-015021-pol2qm74	2626	13	at	at	IN
cord-015021-pol2qm74	2626	14	a	a	DT
cord-015021-pol2qm74	2626	15	dose	dose	NN
cord-015021-pol2qm74	2626	16	of	of	IN
cord-015021-pol2qm74	2626	17	6000	6000	CD
cord-015021-pol2qm74	2626	18	U.	U.	NNP
cord-015021-pol2qm74	2626	19	i.v	i.v	NNP
cord-015021-pol2qm74	2626	20	.	.	.
cord-015021-pol2qm74	2626	21	i0	i0	NNP
cord-015021-pol2qm74	2626	22	min	min	NNP
cord-015021-pol2qm74	2626	23	prior	prior	RB
cord-015021-pol2qm74	2626	24	to	to	IN
cord-015021-pol2qm74	2626	25	ischemia	ischemia	NN
cord-015021-pol2qm74	2626	26	.	.	.
cord-015021-pol2qm74	2627	1	Results	result	NNS
cord-015021-pol2qm74	2627	2	(	(	-LRB-
cord-015021-pol2qm74	2627	3	SOD/	SOD/	NNP
cord-015021-pol2qm74	2627	4	NLA+SOD/	nla+sod/	CD
cord-015021-pol2qm74	2627	5	NI~	NI~	NNP
cord-015021-pol2qm74	2627	6	,	,	,
cord-015021-pol2qm74	2627	7	,	,	,
cord-015021-pol2qm74	2627	8	respectively	respectively	RB
cord-015021-pol2qm74	2627	9	)	)	-RRB-
cord-015021-pol2qm74	2627	10	:	:	:
cord-015021-pol2qm74	2628	1	Bile	bile	NN
cord-015021-pol2qm74	2628	2	flow	flow	NN
cord-015021-pol2qm74	2628	3	(	(	-LRB-
cord-015021-pol2qm74	2629	1	~i	~i	NNP
cord-015021-pol2qm74	2629	2	/	/	SYM
cord-015021-pol2qm74	2629	3	g	g	NN
cord-015021-pol2qm74	2629	4	/	/	SYM
cord-015021-pol2qm74	2629	5	min	min	NN
cord-015021-pol2qm74	2629	6	)	)	-RRB-
cord-015021-pol2qm74	2629	7	:	:	:
cord-015021-pol2qm74	2630	1	0.93±0.11"#/	0.93±0.11"#/	CD
cord-015021-pol2qm74	2630	2	0.52±0.08/	0.52±0.08/	CD
cord-015021-pol2qm74	2631	1	0.48±0.05	0.48±0.05	CD
cord-015021-pol2qm74	2631	2	.	.	.
cord-015021-pol2qm74	2632	1	ALT	ALT	NNP
cord-015021-pol2qm74	2632	2	(	(	-LRB-
cord-015021-pol2qm74	2632	3	U/2	U/2	NNP
cord-015021-pol2qm74	2632	4	)	)	-RRB-
cord-015021-pol2qm74	2633	1	•	•	NNP
cord-015021-pol2qm74	2634	1	171±40~#/	171±40~#/	CD
cord-015021-pol2qm74	2635	1	477±173/	477±173/	CD
cord-015021-pol2qm74	2635	2	506±182	506±182	CD
cord-015021-pol2qm74	2635	3	.	.	.
cord-015021-pol2qm74	2636	1	GLDH	GLDH	NNP
cord-015021-pol2qm74	2637	1	(	(	-LRB-
cord-015021-pol2qm74	2637	2	U	U	NNP
cord-015021-pol2qm74	2637	3	/	/	SYM
cord-015021-pol2qm74	2637	4	l	l	NN
cord-015021-pol2qm74	2637	5	)	)	-RRB-
cord-015021-pol2qm74	2637	6	:	:	:
cord-015021-pol2qm74	2638	1	5.2±1.2e#/	5.2±1.2e#/	CD
cord-015021-pol2qm74	2638	2	10.7±4.2#/	10.7±4.2#/	CD
cord-015021-pol2qm74	2638	3	24.3±9.1	24.3±9.1	CD
cord-015021-pol2qm74	2638	4	.	.	.
cord-015021-pol2qm74	2639	1	In	in	IN
cord-015021-pol2qm74	2639	2	absence	absence	NN
cord-015021-pol2qm74	2639	3	of	of	IN
cord-015021-pol2qm74	2639	4	NLA	NLA	NNP
cord-015021-pol2qm74	2639	5	,	,	,
cord-015021-pol2qm74	2639	6	SOD	SOD	NNP
cord-015021-pol2qm74	2639	7	enhanced	enhance	VBN
cord-015021-pol2qm74	2639	8	postischemic	postischemic	JJ
cord-015021-pol2qm74	2639	9	bile	bile	NN
cord-015021-pol2qm74	2639	10	flow	flow	NN
cord-015021-pol2qm74	2639	11	and	and	CC
cord-015021-pol2qm74	2639	12	reduced	reduce	VBN
cord-015021-pol2qm74	2639	13	leakage	leakage	NN
cord-015021-pol2qm74	2639	14	of	of	IN
cord-015021-pol2qm74	2639	15	ALT	alt	NN
cord-015021-pol2qm74	2639	16	and	and	CC
cord-015021-pol2qm74	2639	17	GLDH	GLDH	NNP
cord-015021-pol2qm74	2639	18	into	into	IN
cord-015021-pol2qm74	2639	19	the	the	DT
cord-015021-pol2qm74	2639	20	plasma	plasma	NN
cord-015021-pol2qm74	2639	21	,	,	,
cord-015021-pol2qm74	2639	22	while	while	IN
cord-015021-pol2qm74	2639	23	the	the	DT
cord-015021-pol2qm74	2639	24	effects	effect	NNS
cord-015021-pol2qm74	2639	25	of	of	IN
cord-015021-pol2qm74	2639	26	SOD	SOD	NNP
cord-015021-pol2qm74	2639	27	disappeared	disappear	VBD
cord-015021-pol2qm74	2639	28	,	,	,
cord-015021-pol2qm74	2639	29	when	when	WRB
cord-015021-pol2qm74	2639	30	endogenous	endogenous	JJ
cord-015021-pol2qm74	2639	31	140~synthesis	140~synthesis	CD
cord-015021-pol2qm74	2639	32	was	be	VBD
cord-015021-pol2qm74	2639	33	inhibited	inhibit	VBN
cord-015021-pol2qm74	2639	34	by	by	IN
cord-015021-pol2qm74	2639	35	NLA	NLA	NNP
cord-015021-pol2qm74	2639	36	.	.	.
cord-015021-pol2qm74	2640	1	NLA	NLA	NNP
cord-015021-pol2qm74	2640	2	had	have	VBD
cord-015021-pol2qm74	2640	3	no	no	DT
cord-015021-pol2qm74	2640	4	~ffect	~ffect	XX
cord-015021-pol2qm74	2640	5	on	on	IN
cord-015021-pol2qm74	2640	6	untreated	untreated	JJ
cord-015021-pol2qm74	2640	7	animals	animal	NNS
cord-015021-pol2qm74	2640	8	submitted	submit	VBN
cord-015021-pol2qm74	2640	9	to	to	IN
cord-015021-pol2qm74	2640	10	the	the	DT
cord-015021-pol2qm74	2640	11	same	same	JJ
cord-015021-pol2qm74	2640	12	protocol	protocol	NN
cord-015021-pol2qm74	2640	13	.	.	.
cord-015021-pol2qm74	2641	1	These	these	DT
cord-015021-pol2qm74	2641	2	results	result	NNS
cord-015021-pol2qm74	2641	3	may	may	MD
cord-015021-pol2qm74	2641	4	suggest	suggest	VB
cord-015021-pol2qm74	2641	5	,	,	,
cord-015021-pol2qm74	2641	6	that	that	IN
cord-015021-pol2qm74	2641	7	oxygen	oxygen	NN
cord-015021-pol2qm74	2641	8	free	free	JJ
cord-015021-pol2qm74	2641	9	radicals	radical	NNS
cord-015021-pol2qm74	2641	10	interfe~:e	interfe~:e	XX
cord-015021-pol2qm74	2641	11	with	with	IN
cord-015021-pol2qm74	2641	12	the	the	DT
cord-015021-pol2qm74	2641	13	endogenous	endogenous	JJ
cord-015021-pol2qm74	2641	14	vasodilator	vasodilator	NN
cord-015021-pol2qm74	2641	15	NO	no	UH
cord-015021-pol2qm74	2641	16	and	and	CC
cord-015021-pol2qm74	2641	17	that	that	IN
cord-015021-pol2qm74	2641	18	the	the	DT
cord-015021-pol2qm74	2641	19	benefit	benefit	NN
cord-015021-pol2qm74	2641	20	of	of	IN
cord-015021-pol2qm74	2641	21	SOD	SOD	NNP
cord-015021-pol2qm74	2641	22	can	can	MD
cord-015021-pol2qm74	2641	23	be	be	VB
cord-015021-pol2qm74	2641	24	attribuated	attribuate	VBN
cord-015021-pol2qm74	2641	25	in	in	IN
cord-015021-pol2qm74	2641	26	large	large	JJ
cord-015021-pol2qm74	2641	27	part	part	NN
cord-015021-pol2qm74	2641	28	to	to	IN
cord-015021-pol2qm74	2641	29	a	a	DT
cord-015021-pol2qm74	2641	30	protection	protection	NN
cord-015021-pol2qm74	2641	31	of	of	IN
cord-015021-pol2qm74	2641	32	NO	no	DT
cord-015021-pol2qm74	2641	33	during	during	IN
cord-015021-pol2qm74	2641	34	reperfusion	reperfusion	NN
cord-015021-pol2qm74	2641	35	.	.	.
cord-015021-pol2qm74	2642	1	Nitric	nitric	NN
cord-015021-pol2qm74	2642	2	oxide	oxide	NN
cord-015021-pol2qm74	2642	3	(	(	-LRB-
cord-015021-pol2qm74	2642	4	NO	no	RB
cord-015021-pol2qm74	2642	5	)	)	-RRB-
cord-015021-pol2qm74	2642	6	reduces	reduce	VBZ
cord-015021-pol2qm74	2642	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	2642	8	vascular	vascular	JJ
cord-015021-pol2qm74	2642	9	resistance	resistance	NN
cord-015021-pol2qm74	2642	10	and	and	CC
cord-015021-pol2qm74	2642	11	increases	increase	VBZ
cord-015021-pol2qm74	2642	12	oxygenation	oxygenation	NN
cord-015021-pol2qm74	2642	13	by	by	IN
cord-015021-pol2qm74	2642	14	inhalation	inhalation	NN
cord-015021-pol2qm74	2642	15	in	in	IN
cord-015021-pol2qm74	2642	16	ARDS	ARDS	NNP
cord-015021-pol2qm74	2642	17	patients	patient	NNS
cord-015021-pol2qm74	2642	18	[	[	-LRB-
cord-015021-pol2qm74	2642	19	1	1	CD
cord-015021-pol2qm74	2642	20	]	]	-RRB-
cord-015021-pol2qm74	2642	21	.	.	.
cord-015021-pol2qm74	2643	1	Animal	animal	NN
cord-015021-pol2qm74	2643	2	studies	study	NNS
cord-015021-pol2qm74	2643	3	on	on	IN
cord-015021-pol2qm74	2643	4	the	the	DT
cord-015021-pol2qm74	2643	5	endogeneous	endogeneous	JJ
cord-015021-pol2qm74	2643	6	NO	no	DT
cord-015021-pol2qm74	2643	7	production	production	NN
cord-015021-pol2qm74	2643	8	proved	prove	VBD
cord-015021-pol2qm74	2643	9	that	that	IN
cord-015021-pol2qm74	2643	10	NO	no	DT
cord-015021-pol2qm74	2643	11	is	be	VBZ
cord-015021-pol2qm74	2643	12	exhaled	exhale	VBN
cord-015021-pol2qm74	2643	13	after	after	IN
cord-015021-pol2qm74	2643	14	synthesis	synthesis	NN
cord-015021-pol2qm74	2643	15	in	in	IN
cord-015021-pol2qm74	2643	16	the	the	DT
cord-015021-pol2qm74	2643	17	respiratory	respiratory	JJ
cord-015021-pol2qm74	2643	18	tract	tract	NN
cord-015021-pol2qm74	2643	19	[	[	-LRB-
cord-015021-pol2qm74	2643	20	2	2	CD
cord-015021-pol2qm74	2643	21	]	]	-RRB-
cord-015021-pol2qm74	2643	22	.	.	.
cord-015021-pol2qm74	2644	1	With	with	IN
cord-015021-pol2qm74	2644	2	approval	approval	NN
cord-015021-pol2qm74	2644	3	by	by	IN
cord-015021-pol2qm74	2644	4	the	the	DT
cord-015021-pol2qm74	2644	5	hospital	hospital	NN
cord-015021-pol2qm74	2644	6	ethics	ethic	NNS
cord-015021-pol2qm74	2644	7	committee	committee	NNP
cord-015021-pol2qm74	2644	8	,	,	,
cord-015021-pol2qm74	2644	9	we	-PRON-	PRP
cord-015021-pol2qm74	2644	10	studied	study	VBD
cord-015021-pol2qm74	2644	11	healthy	healthy	JJ
cord-015021-pol2qm74	2644	12	volunteers	volunteer	NNS
cord-015021-pol2qm74	2644	13	and	and	CC
cord-015021-pol2qm74	2644	14	ventilated	ventilate	VBN
cord-015021-pol2qm74	2644	15	patients	patient	NNS
cord-015021-pol2qm74	2644	16	by	by	IN
cord-015021-pol2qm74	2644	17	measurement	measurement	NN
cord-015021-pol2qm74	2644	18	of	of	IN
cord-015021-pol2qm74	2644	19	inand	inand	NN
cord-015021-pol2qm74	2644	20	exhaled	exhale	VBN
cord-015021-pol2qm74	2644	21	NO	no	RB
cord-015021-pol2qm74	2644	22	by	by	IN
cord-015021-pol2qm74	2644	23	NO	no	NN
cord-015021-pol2qm74	2644	24	/	/	SYM
cord-015021-pol2qm74	2644	25	NO2-chemiluminescence	no2-chemiluminescence	NN
cord-015021-pol2qm74	2644	26	in	in	IN
cord-015021-pol2qm74	2644	27	segments	segment	NNS
cord-015021-pol2qm74	2644	28	of	of	IN
cord-015021-pol2qm74	2644	29	the	the	DT
cord-015021-pol2qm74	2644	30	upper	upper	JJ
cord-015021-pol2qm74	2644	31	respiratory	respiratory	JJ
cord-015021-pol2qm74	2644	32	tract	tract	NN
cord-015021-pol2qm74	2644	33	.	.	.
cord-015021-pol2qm74	2645	1	We	-PRON-	PRP
cord-015021-pol2qm74	2645	2	found	find	VBD
cord-015021-pol2qm74	2645	3	that	that	IN
cord-015021-pol2qm74	2645	4	NO	no	NN
cord-015021-pol2qm74	2645	5	is	be	VBZ
cord-015021-pol2qm74	2645	6	synthesized	synthesize	VBN
cord-015021-pol2qm74	2645	7	predominantly	predominantly	RB
cord-015021-pol2qm74	2645	8	in	in	IN
cord-015021-pol2qm74	2645	9	the	the	DT
cord-015021-pol2qm74	2645	10	nose	nose	NN
cord-015021-pol2qm74	2645	11	and	and	CC
cord-015021-pol2qm74	2645	12	in	in	IN
cord-015021-pol2qm74	2645	13	the	the	DT
cord-015021-pol2qm74	2645	14	upper	upper	JJ
cord-015021-pol2qm74	2645	15	nasopharynx	nasopharynx	NN
cord-015021-pol2qm74	2645	16	,	,	,
cord-015021-pol2qm74	2645	17	leading	lead	VBG
cord-015021-pol2qm74	2645	18	to	to	IN
cord-015021-pol2qm74	2645	19	inspiratory	inspiratory	JJ
cord-015021-pol2qm74	2645	20	tracheal	tracheal	NN
cord-015021-pol2qm74	2645	21	NO	no	DT
cord-015021-pol2qm74	2645	22	concentrations	concentration	NNS
cord-015021-pol2qm74	2645	23	of	of	IN
cord-015021-pol2qm74	2645	24	0.07	0.07	CD
cord-015021-pol2qm74	2645	25	-	-	HYPH
cord-015021-pol2qm74	2645	26	0.13	0.13	CD
cord-015021-pol2qm74	2645	27	parts	part	NNS
cord-015021-pol2qm74	2645	28	per	per	IN
cord-015021-pol2qm74	2645	29	million	million	CD
cord-015021-pol2qm74	2645	30	in	in	IN
cord-015021-pol2qm74	2645	31	non	non	JJ
cord-015021-pol2qm74	2645	32	-	-	JJ
cord-015021-pol2qm74	2645	33	smoking	smoking	JJ
cord-015021-pol2qm74	2645	34	volunteers	volunteer	NNS
cord-015021-pol2qm74	2645	35	;	;	:
cord-015021-pol2qm74	2645	36	data	datum	NNS
cord-015021-pol2qm74	2645	37	during	during	IN
cord-015021-pol2qm74	2645	38	mask	mask	NN
cord-015021-pol2qm74	2645	39	ventilation	ventilation	NN
cord-015021-pol2qm74	2645	40	per	per	IN
cord-015021-pol2qm74	2645	41	nose	nose	NN
cord-015021-pol2qm74	2645	42	were	be	VBD
cord-015021-pol2qm74	2645	43	as	as	IN
cord-015021-pol2qm74	2645	44	follows	follow	VBZ
cord-015021-pol2qm74	2645	45	:	:	:
cord-015021-pol2qm74	2646	1	Non	non	JJ
cord-015021-pol2qm74	2646	2	0.089	0.089	CD
cord-015021-pol2qm74	2646	3	0.0422	0.0422	CD
cord-015021-pol2qm74	2647	1	0.0721	0.0721	CD
cord-015021-pol2qm74	2647	2	0.0311,2	0.0311,2	CD
cord-015021-pol2qm74	2648	1	Parts	part	NNS
cord-015021-pol2qm74	2648	2	per	per	IN
cord-015021-pol2qm74	2648	3	million	million	CD
cord-015021-pol2qm74	2648	4	(	(	-LRB-
cord-015021-pol2qm74	2648	5	ppm	ppm	NN
cord-015021-pol2qm74	2648	6	)	)	-RRB-
cord-015021-pol2qm74	2649	1	NO	no	UH
cord-015021-pol2qm74	2649	2	,	,	,
cord-015021-pol2qm74	2649	3	mean	mean	UH
cord-015021-pol2qm74	2649	4	,	,	,
cord-015021-pol2qm74	2649	5	n	n	NN
cord-015021-pol2qm74	2649	6	=	=	SYM
cord-015021-pol2qm74	2649	7	10	10	CD
cord-015021-pol2qm74	2649	8	;	;	:
cord-015021-pol2qm74	2649	9	~	~	CD
cord-015021-pol2qm74	2649	10	p	p	NN
cord-015021-pol2qm74	2649	11	<	<	XX
cord-015021-pol2qm74	2649	12	0.05	0.05	CD
cord-015021-pol2qm74	2649	13	(	(	-LRB-
cord-015021-pol2qm74	2649	14	t	t	NN
cord-015021-pol2qm74	2649	15	-	-	HYPH
cord-015021-pol2qm74	2649	16	test	test	NN
cord-015021-pol2qm74	2649	17	)	)	-RRB-
cord-015021-pol2qm74	2649	18	between	between	IN
cord-015021-pol2qm74	2649	19	smokers	smoker	NNS
cord-015021-pol2qm74	2649	20	and	and	CC
cord-015021-pol2qm74	2649	21	non	non	NNS
cord-015021-pol2qm74	2649	22	-	-	NNS
cord-015021-pol2qm74	2649	23	smokers	smoker	NNS
cord-015021-pol2qm74	2649	24	;	;	:
cord-015021-pol2qm74	2649	25	2	2	CD
cord-015021-pol2qm74	2649	26	p	p	NN
cord-015021-pol2qm74	2649	27	<	<	XX
cord-015021-pol2qm74	2649	28	0.05	0.05	CD
cord-015021-pol2qm74	2649	29	(	(	-LRB-
cord-015021-pol2qm74	2649	30	t	t	NN
cord-015021-pol2qm74	2649	31	-	-	HYPH
cord-015021-pol2qm74	2649	32	test	test	NN
cord-015021-pol2qm74	2649	33	)	)	-RRB-
cord-015021-pol2qm74	2649	34	between	between	IN
cord-015021-pol2qm74	2649	35	in	in	IN
cord-015021-pol2qm74	2649	36	-	-	HYPH
cord-015021-pol2qm74	2649	37	and	and	CC
cord-015021-pol2qm74	2649	38	expiration	expiration	NN
cord-015021-pol2qm74	2649	39	.	.	.
cord-015021-pol2qm74	2650	1	About	about	RB
cord-015021-pol2qm74	2650	2	50	50	CD
cord-015021-pol2qm74	2650	3	%	%	NN
cord-015021-pol2qm74	2650	4	of	of	IN
cord-015021-pol2qm74	2650	5	NO	no	DT
cord-015021-pol2qm74	2650	6	is	be	VBZ
cord-015021-pol2qm74	2650	7	resorbe.d	resorbe.d	NN
cord-015021-pol2qm74	2650	8	by	by	IN
cord-015021-pol2qm74	2650	9	the	the	DT
cord-015021-pol2qm74	2650	10	lung	lung	NN
cord-015021-pol2qm74	2650	11	,	,	,
cord-015021-pol2qm74	2650	12	and	and	CC
cord-015021-pol2qm74	2650	13	the	the	DT
cord-015021-pol2qm74	2650	14	exhaled	exhale	VBN
cord-015021-pol2qm74	2650	15	NO	no	NN
cord-015021-pol2qm74	2650	16	-in	-in	IN
cord-015021-pol2qm74	2650	17	contrast	contrast	NN
cord-015021-pol2qm74	2650	18	to	to	IN
cord-015021-pol2qm74	2650	19	former	former	JJ
cord-015021-pol2qm74	2650	20	presumptions	presumption	NNS
cord-015021-pol2qm74	2650	21	-is	-is	NFP
cord-015021-pol2qm74	2650	22	the	the	DT
cord-015021-pol2qm74	2650	23	remaining	remain	VBG
cord-015021-pol2qm74	2650	24	part	part	NN
cord-015021-pol2qm74	2650	25	of	of	IN
cord-015021-pol2qm74	2651	1	the	the	DT
cord-015021-pol2qm74	2651	2	autoinhaled	autoinhaled	JJ
cord-015021-pol2qm74	2651	3	NO	no	NN
cord-015021-pol2qm74	2651	4	.	.	.
cord-015021-pol2qm74	2652	1	Intubated	intubated	JJ
cord-015021-pol2qm74	2652	2	and	and	CC
cord-015021-pol2qm74	2652	3	ventilated	ventilate	VBN
cord-015021-pol2qm74	2652	4	patients	patient	NNS
cord-015021-pol2qm74	2652	5	are	be	VBP
cord-015021-pol2qm74	2652	6	deprived	deprive	VBN
cord-015021-pol2qm74	2652	7	of	of	IN
cord-015021-pol2qm74	2652	8	NO	no	DT
cord-015021-pol2qm74	2652	9	autoinhalation	autoinhalation	NN
cord-015021-pol2qm74	2652	10	,	,	,
cord-015021-pol2qm74	2652	11	and	and	CC
cord-015021-pol2qm74	2652	12	the	the	DT
cord-015021-pol2qm74	2652	13	exhaled	exhaled	JJ
cord-015021-pol2qm74	2652	14	NO	no	NN
cord-015021-pol2qm74	2652	15	in	in	IN
cord-015021-pol2qm74	2652	16	the	the	DT
cord-015021-pol2qm74	2652	17	trachea	trachea	NN
cord-015021-pol2qm74	2652	18	decreases	decrease	VBZ
cord-015021-pol2qm74	2652	19	more	more	JJR
cord-015021-pol2qm74	2652	20	than	than	IN
cord-015021-pol2qm74	2652	21	95	95	CD
cord-015021-pol2qm74	2652	22	%	%	NN
cord-015021-pol2qm74	2652	23	{	{	-LRB-
cord-015021-pol2qm74	2652	24	O.043	O.043	NNP
cord-015021-pol2qm74	2652	25	ppm	ppm	NN
cord-015021-pol2qm74	2652	26	before	before	IN
cord-015021-pol2qm74	2652	27	intubation	intubation	NN
cord-015021-pol2qm74	2652	28	vs.	vs.	CC
cord-015021-pol2qm74	2652	29	0.003	0.003	CD
cord-015021-pol2qm74	2652	30	ppm	ppm	NN
cord-015021-pol2qm74	2652	31	after	after	IN
cord-015021-pol2qm74	2652	32	intubation	intubation	NN
cord-015021-pol2qm74	2652	33	,	,	,
cord-015021-pol2qm74	2652	34	~	~	NFP
cord-015021-pol2qm74	2652	35	,	,	,
cord-015021-pol2qm74	2652	36	<	<	XX
cord-015021-pol2qm74	2652	37	0.01	0.01	CD
cord-015021-pol2qm74	2652	38	)	)	-RRB-
cord-015021-pol2qm74	2652	39	,	,	,
cord-015021-pol2qm74	2652	40	whereas	whereas	IN
cord-015021-pol2qm74	2652	41	the	the	DT
cord-015021-pol2qm74	2652	42	nasal	nasal	NN
cord-015021-pol2qm74	2652	43	NO	no	DT
cord-015021-pol2qm74	2652	44	concentration	concentration	NN
cord-015021-pol2qm74	2652	45	increases	increase	NNS
cord-015021-pol2qm74	2652	46	by	by	IN
cord-015021-pol2qm74	2652	47	cumulation	cumulation	NN
cord-015021-pol2qm74	2652	48	.	.	.
cord-015021-pol2qm74	2653	1	Hence	hence	RB
cord-015021-pol2qm74	2653	2	,	,	,
cord-015021-pol2qm74	2653	3	low	low	JJ
cord-015021-pol2qm74	2653	4	-	-	HYPH
cord-015021-pol2qm74	2653	5	dose	dose	NN
cord-015021-pol2qm74	2653	6	NO	no	DT
cord-015021-pol2qm74	2653	7	inhalation	inhalation	NN
cord-015021-pol2qm74	2653	8	in	in	IN
cord-015021-pol2qm74	2653	9	ARDS	ARDS	NNP
cord-015021-pol2qm74	2653	10	patients	patient	NNS
cord-015021-pol2qm74	2653	11	might	may	MD
cord-015021-pol2qm74	2653	12	be	be	VB
cord-015021-pol2qm74	2653	13	considered	consider	VBN
cord-015021-pol2qm74	2653	14	as	as	IN
cord-015021-pol2qm74	2653	15	a	a	DT
cord-015021-pol2qm74	2653	16	NO	no	DT
cord-015021-pol2qm74	2653	17	replacement	replacement	NN
cord-015021-pol2qm74	2653	18	,	,	,
cord-015021-pol2qm74	2653	19	especially	especially	RB
cord-015021-pol2qm74	2653	20	since	since	IN
cord-015021-pol2qm74	2653	21	the	the	DT
cord-015021-pol2qm74	2653	22	tracheal	tracheal	NN
cord-015021-pol2qm74	2654	1	NO	no	DT
cord-015021-pol2qm74	2654	2	concentrations	concentration	NNS
cord-015021-pol2qm74	2654	3	we	-PRON-	PRP
cord-015021-pol2qm74	2654	4	measured	measure	VBD
cord-015021-pol2qm74	2654	5	in	in	IN
cord-015021-pol2qm74	2654	6	volunteers	volunteer	NNS
cord-015021-pol2qm74	2654	7	are	be	VBP
cord-015021-pol2qm74	2654	8	similar	similar	JJ
cord-015021-pol2qm74	2654	9	to	to	IN
cord-015021-pol2qm74	2654	10	those	those	DT
cord-015021-pol2qm74	2654	11	which	which	WDT
cord-015021-pol2qm74	2654	12	could	could	MD
cord-015021-pol2qm74	2654	13	be	be	VB
cord-015021-pol2qm74	2654	14	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2654	15	to	to	TO
cord-015021-pol2qm74	2654	16	be	be	VB
cord-015021-pol2qm74	2654	17	effective	effective	JJ
cord-015021-pol2qm74	2654	18	for	for	IN
cord-015021-pol2qm74	2654	19	ARDS	ARDS	NNP
cord-015021-pol2qm74	2654	20	in	in	IN
cord-015021-pol2qm74	2654	21	former	former	JJ
cord-015021-pol2qm74	2654	22	studies	study	NNS
cord-015021-pol2qm74	2654	23	[	[	-LRB-
cord-015021-pol2qm74	2654	24	3	3	CD
cord-015021-pol2qm74	2654	25	]	]	-RRB-
cord-015021-pol2qm74	2654	26	.	.	.
cord-015021-pol2qm74	2655	1	The	the	DT
cord-015021-pol2qm74	2655	2	data	datum	NNS
cord-015021-pol2qm74	2655	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2655	4	that	that	IN
cord-015021-pol2qm74	2655	5	NO	no	NN
cord-015021-pol2qm74	2655	6	is	be	VBZ
cord-015021-pol2qm74	2655	7	synthesized	synthesize	VBN
cord-015021-pol2qm74	2655	8	in	in	IN
cord-015021-pol2qm74	2655	9	the	the	DT
cord-015021-pol2qm74	2655	10	nose	nose	NN
cord-015021-pol2qm74	2655	11	,	,	,
cord-015021-pol2qm74	2655	12	and	and	CC
cord-015021-pol2qm74	2655	13	inhaled	inhale	VBN
cord-015021-pol2qm74	2655	14	and	and	CC
cord-015021-pol2qm74	2655	15	resorbed	resorb	VBN
cord-015021-pol2qm74	2655	16	by	by	IN
cord-015021-pol2qm74	2655	17	the	the	DT
cord-015021-pol2qm74	2655	18	lung	lung	NN
cord-015021-pol2qm74	2655	19	.	.	.
cord-015021-pol2qm74	2656	1	This	this	DT
cord-015021-pol2qm74	2656	2	phenomenon	phenomenon	NN
cord-015021-pol2qm74	2656	3	of	of	IN
cord-015021-pol2qm74	2656	4	NO	no	DT
cord-015021-pol2qm74	2656	5	autoinhalation	autoinhalation	NN
cord-015021-pol2qm74	2656	6	,	,	,
cord-015021-pol2qm74	2656	7	which	which	WDT
cord-015021-pol2qm74	2656	8	is	be	VBZ
cord-015021-pol2qm74	2656	9	reduced	reduce	VBN
cord-015021-pol2qm74	2656	10	in	in	IN
cord-015021-pol2qm74	2656	11	smokers	smoker	NNS
cord-015021-pol2qm74	2656	12	and	and	CC
cord-015021-pol2qm74	2656	13	in	in	IN
cord-015021-pol2qm74	2656	14	ventilated	ventilate	VBN
cord-015021-pol2qm74	2656	15	patients	patient	NNS
cord-015021-pol2qm74	2656	16	,	,	,
cord-015021-pol2qm74	2656	17	does	do	VBZ
cord-015021-pol2qm74	2656	18	possibly	possibly	RB
cord-015021-pol2qm74	2656	19	contribute	contribute	VB
cord-015021-pol2qm74	2656	20	to	to	IN
cord-015021-pol2qm74	2656	21	the	the	DT
cord-015021-pol2qm74	2656	22	regulation	regulation	NN
cord-015021-pol2qm74	2656	23	of	of	IN
cord-015021-pol2qm74	2656	24	the	the	DT
cord-015021-pol2qm74	2656	25	ventilation	ventilation	NN
cord-015021-pol2qm74	2656	26	-	-	HYPH
cord-015021-pol2qm74	2656	27	perfusion	perfusion	NN
cord-015021-pol2qm74	2656	28	ratio	ratio	NN
cord-015021-pol2qm74	2656	29	in	in	IN
cord-015021-pol2qm74	2656	30	the	the	DT
cord-015021-pol2qm74	2656	31	lung	lung	NN
cord-015021-pol2qm74	2656	32	.	.	.
cord-015021-pol2qm74	2656	33	 	 	_SP
cord-015021-pol2qm74	2657	1	Kikuchi	Kikuchi	NNP
cord-015021-pol2qm74	2657	2	1	1	CD
cord-015021-pol2qm74	2657	3	,	,	,
cord-015021-pol2qm74	2657	4	Yoshihiro	Yoshihiro	NNP
cord-015021-pol2qm74	2657	5	Inoue	Inoue	NNP
cord-015021-pol2qm74	2657	6	1	1	CD
cord-015021-pol2qm74	2657	7	,	,	,
cord-015021-pol2qm74	2657	8	Masao	Masao	NNP
cord-015021-pol2qm74	2657	9	Yoshida	Yoshida	NNP
cord-015021-pol2qm74	2657	10	2	2	CD
cord-015021-pol2qm74	2657	11	1	1	CD
cord-015021-pol2qm74	2657	12	Critical	Critical	NNP
cord-015021-pol2qm74	2657	13	Care	Care	NNP
cord-015021-pol2qm74	2657	14	and	and	CC
cord-015021-pol2qm74	2657	15	Emergency	Emergency	NNP
cord-015021-pol2qm74	2657	16	Center	Center	NNP
cord-015021-pol2qm74	2657	17	,	,	,
cord-015021-pol2qm74	2657	18	and	and	CC
cord-015021-pol2qm74	2657	19	2Department	2department	CD
cord-015021-pol2qm74	2657	20	of	of	IN
cord-015021-pol2qm74	2657	21	Bacteriology	Bacteriology	NNP
cord-015021-pol2qm74	2657	22	,	,	,
cord-015021-pol2qm74	2657	23	Iwate	Iwate	NNP
cord-015021-pol2qm74	2657	24	Medical	Medical	NNP
cord-015021-pol2qm74	2657	25	University	University	NNP
cord-015021-pol2qm74	2657	26	.	.	.
cord-015021-pol2qm74	2658	1	Nitric	nitric	NN
cord-015021-pol2qm74	2658	2	oxide	oxide	NN
cord-015021-pol2qm74	2658	3	(	(	-LRB-
cord-015021-pol2qm74	2658	4	NO	no	UH
cord-015021-pol2qm74	2658	5	)	)	-RRB-
cord-015021-pol2qm74	2658	6	is	be	VBZ
cord-015021-pol2qm74	2658	7	produced	produce	VBN
cord-015021-pol2qm74	2658	8	by	by	IN
cord-015021-pol2qm74	2658	9	macrophages	macrophage	NNS
cord-015021-pol2qm74	2658	10	and	and	CC
cord-015021-pol2qm74	2658	11	vascular	vascular	JJ
cord-015021-pol2qm74	2658	12	endothelial	endothelial	JJ
cord-015021-pol2qm74	2658	13	cells	cell	NNS
cord-015021-pol2qm74	2658	14	.	.	.
cord-015021-pol2qm74	2659	1	It	-PRON-	PRP
cord-015021-pol2qm74	2659	2	is	be	VBZ
cord-015021-pol2qm74	2659	3	thought	think	VBN
cord-015021-pol2qm74	2659	4	to	to	TO
cord-015021-pol2qm74	2659	5	be	be	VB
cord-015021-pol2qm74	2659	6	the	the	DT
cord-015021-pol2qm74	2659	7	true	true	JJ
cord-015021-pol2qm74	2659	8	form	form	NN
cord-015021-pol2qm74	2659	9	of	of	IN
cord-015021-pol2qm74	2659	10	endotheliumderived	endotheliumderived	JJ
cord-015021-pol2qm74	2659	11	relaxing	relaxing	NN
cord-015021-pol2qm74	2659	12	factor	factor	NN
cord-015021-pol2qm74	2659	13	,	,	,
cord-015021-pol2qm74	2659	14	and	and	CC
cord-015021-pol2qm74	2659	15	to	to	TO
cord-015021-pol2qm74	2659	16	be	be	VB
cord-015021-pol2qm74	2659	17	involved	involve	VBN
cord-015021-pol2qm74	2659	18	in	in	IN
cord-015021-pol2qm74	2659	19	the	the	DT
cord-015021-pol2qm74	2659	20	fall	fall	NN
cord-015021-pol2qm74	2659	21	of	of	IN
cord-015021-pol2qm74	2659	22	blood	blood	NN
cord-015021-pol2qm74	2659	23	pressure	pressure	NN
cord-015021-pol2qm74	2659	24	during	during	IN
cord-015021-pol2qm74	2659	25	septic	septic	JJ
cord-015021-pol2qm74	2659	26	shock	shock	NN
cord-015021-pol2qm74	2659	27	.	.	.
cord-015021-pol2qm74	2660	1	We	-PRON-	PRP
cord-015021-pol2qm74	2660	2	have	have	VBP
cord-015021-pol2qm74	2660	3	reported	report	VBN
cord-015021-pol2qm74	2660	4	previously	previously	RB
cord-015021-pol2qm74	2660	5	that	that	IN
cord-015021-pol2qm74	2660	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2660	7	(	(	-LRB-
cord-015021-pol2qm74	2660	8	LPS	LPS	NNP
cord-015021-pol2qm74	2660	9	)	)	-RRB-
cord-015021-pol2qm74	2660	10	,	,	,
cord-015021-pol2qm74	2660	11	TNF	TNF	NNP
cord-015021-pol2qm74	2660	12	-	-	HYPH
cord-015021-pol2qm74	2660	13	c~	c~	NNP
cord-015021-pol2qm74	2660	14	and	and	CC
cord-015021-pol2qm74	2660	15	IL-2	IL-2	NNP
cord-015021-pol2qm74	2660	16	contribute	contribute	VBP
cord-015021-pol2qm74	2660	17	to	to	IN
cord-015021-pol2qm74	2660	18	the	the	DT
cord-015021-pol2qm74	2660	19	occurrence	occurrence	NN
cord-015021-pol2qm74	2660	20	of	of	IN
cord-015021-pol2qm74	2660	21	septic	septic	JJ
cord-015021-pol2qm74	2660	22	shock	shock	NN
cord-015021-pol2qm74	2660	23	(	(	-LRB-
cord-015021-pol2qm74	2660	24	Circ	Circ	NNP
cord-015021-pol2qm74	2660	25	Shock	Shock	NNP
cord-015021-pol2qm74	2660	26	38:264	38:264	CD
cord-015021-pol2qm74	2660	27	;	;	:
cord-015021-pol2qm74	2660	28	.	.	.
cord-015021-pol2qm74	2661	1	The	the	DT
cord-015021-pol2qm74	2661	2	present	present	JJ
cord-015021-pol2qm74	2661	3	study	study	NN
cord-015021-pol2qm74	2661	4	investigated	investigate	VBD
cord-015021-pol2qm74	2661	5	the	the	DT
cord-015021-pol2qm74	2661	6	in	in	FW
cord-015021-pol2qm74	2661	7	vitro	vitro	FW
cord-015021-pol2qm74	2661	8	effects	effect	NNS
cord-015021-pol2qm74	2661	9	of	of	IN
cord-015021-pol2qm74	2661	10	LPS	LPS	NNP
cord-015021-pol2qm74	2661	11	,	,	,
cord-015021-pol2qm74	2661	12	TNF	TNF	NNP
cord-015021-pol2qm74	2661	13	-	-	HYPH
cord-015021-pol2qm74	2661	14	o~	o~	NNP
cord-015021-pol2qm74	2661	15	,	,	,
cord-015021-pol2qm74	2661	16	IL-2	IL-2	NNP
cord-015021-pol2qm74	2661	17	and	and	CC
cord-015021-pol2qm74	2661	18	IFN-'I	ifn-'i	NN
cord-015021-pol2qm74	2661	19	on	on	IN
cord-015021-pol2qm74	2661	20	the	the	DT
cord-015021-pol2qm74	2661	21	production	production	NN
cord-015021-pol2qm74	2661	22	of	of	IN
cord-015021-pol2qm74	2661	23	NO	no	NN
cord-015021-pol2qm74	2661	24	by	by	IN
cord-015021-pol2qm74	2661	25	macrophages	macrophage	NNS
cord-015021-pol2qm74	2661	26	.	.	.
cord-015021-pol2qm74	2662	1	Peritoneal	peritoneal	JJ
cord-015021-pol2qm74	2662	2	macrophages	macrophage	NNS
cord-015021-pol2qm74	2662	3	were	be	VBD
cord-015021-pol2qm74	2662	4	cultured	culture	VBN
cord-015021-pol2qm74	2662	5	with	with	IN
cord-015021-pol2qm74	2662	6	LPS	LPS	NNP
cord-015021-pol2qm74	2662	7	,	,	,
cord-015021-pol2qm74	2662	8	IL-2	IL-2	NNP
cord-015021-pol2qm74	2662	9	,	,	,
cord-015021-pol2qm74	2662	10	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	2662	11	and	and	CC
cord-015021-pol2qm74	2662	12	IFN-¥.	ifn-¥.	NN
cord-015021-pol2qm74	2663	1	In	in	IN
cord-015021-pol2qm74	2663	2	culture	culture	NN
cord-015021-pol2qm74	2663	3	with	with	IN
cord-015021-pol2qm74	2663	4	LPS	LPS	NNP
cord-015021-pol2qm74	2663	5	,	,	,
cord-015021-pol2qm74	2663	6	NO	NO	NNP
cord-015021-pol2qm74	2663	7	was	be	VBD
cord-015021-pol2qm74	2663	8	produced	produce	VBN
cord-015021-pol2qm74	2663	9	in	in	IN
cord-015021-pol2qm74	2663	10	a	a	DT
cord-015021-pol2qm74	2663	11	dose	dose	NN
cord-015021-pol2qm74	2663	12	-	-	HYPH
cord-015021-pol2qm74	2663	13	dependent	dependent	JJ
cord-015021-pol2qm74	2663	14	manner	manner	NN
cord-015021-pol2qm74	2663	15	,	,	,
cord-015021-pol2qm74	2663	16	and	and	CC
cord-015021-pol2qm74	2663	17	the	the	DT
cord-015021-pol2qm74	2663	18	production	production	NN
cord-015021-pol2qm74	2663	19	was	be	VBD
cord-015021-pol2qm74	2663	20	suppressed	suppress	VBN
cord-015021-pol2qm74	2663	21	by	by	IN
cord-015021-pol2qm74	2663	22	a	a	DT
cord-015021-pol2qm74	2663	23	NO	no	JJ
cord-015021-pol2qm74	2663	24	production	production	NN
cord-015021-pol2qm74	2663	25	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2663	26	,	,	,
cord-015021-pol2qm74	2663	27	L	L	NNP
cord-015021-pol2qm74	2663	28	-	-	HYPH
cord-015021-pol2qm74	2663	29	NMMA	NMMA	NNP
cord-015021-pol2qm74	2663	30	.	.	.
cord-015021-pol2qm74	2664	1	IFN	IFN	NNP
cord-015021-pol2qm74	2664	2	-	-	HYPH
cord-015021-pol2qm74	2664	3	Y	Y	NNP
cord-015021-pol2qm74	2664	4	,	,	,
cord-015021-pol2qm74	2664	5	IL-2	IL-2	NNP
cord-015021-pol2qm74	2664	6	and	and	CC
cord-015021-pol2qm74	2664	7	TNF	TNF	NNP
cord-015021-pol2qm74	2664	8	-	-	HYPH
cord-015021-pol2qm74	2664	9	c~	c~	NNP
cord-015021-pol2qm74	2664	10	used	use	VBN
cord-015021-pol2qm74	2664	11	alone	alone	RB
cord-015021-pol2qm74	2664	12	did	do	VBD
cord-015021-pol2qm74	2664	13	not	not	RB
cord-015021-pol2qm74	2664	14	promote	promote	VB
cord-015021-pol2qm74	2664	15	the	the	DT
cord-015021-pol2qm74	2664	16	production	production	NN
cord-015021-pol2qm74	2664	17	of	of	IN
cord-015021-pol2qm74	2664	18	NO	no	NN
cord-015021-pol2qm74	2664	19	,	,	,
cord-015021-pol2qm74	2664	20	but	but	CC
cord-015021-pol2qm74	2664	21	helped	help	VBD
cord-015021-pol2qm74	2664	22	LPS	LPS	NNP
cord-015021-pol2qm74	2664	23	to	to	TO
cord-015021-pol2qm74	2664	24	facilitate	facilitate	VB
cord-015021-pol2qm74	2664	25	NO	no	DT
cord-015021-pol2qm74	2664	26	production	production	NN
cord-015021-pol2qm74	2664	27	.	.	.
cord-015021-pol2qm74	2665	1	A	a	DT
cord-015021-pol2qm74	2665	2	combination	combination	NN
cord-015021-pol2qm74	2665	3	of	of	IN
cord-015021-pol2qm74	2665	4	IL-2	IL-2	NNP
cord-015021-pol2qm74	2665	5	and	and	CC
cord-015021-pol2qm74	2665	6	TNF	TNF	NNP
cord-015021-pol2qm74	2665	7	-	-	HYPH
cord-015021-pol2qm74	2665	8	c	c	NNP
cord-015021-pol2qm74	2665	9	(	(	-LRB-
cord-015021-pol2qm74	2665	10	enhanced	enhanced	JJ
cord-015021-pol2qm74	2665	11	LPS	LPS	NNP
cord-015021-pol2qm74	2665	12	-	-	HYPH
cord-015021-pol2qm74	2665	13	facilitated	facilitate	VBN
cord-015021-pol2qm74	2665	14	NO	no	DT
cord-015021-pol2qm74	2665	15	production	production	NN
cord-015021-pol2qm74	2665	16	to	to	IN
cord-015021-pol2qm74	2665	17	a	a	DT
cord-015021-pol2qm74	2665	18	greater	great	JJR
cord-015021-pol2qm74	2665	19	extent	extent	NN
cord-015021-pol2qm74	2665	20	than	than	IN
cord-015021-pol2qm74	2666	1	IL-2	IL-2	NNP
cord-015021-pol2qm74	2666	2	or	or	CC
cord-015021-pol2qm74	2666	3	TNF	TNF	NNP
cord-015021-pol2qm74	2666	4	-	-	:
cord-015021-pol2qm74	2666	5	c~	c~	NNP
cord-015021-pol2qm74	2666	6	alone	alone	RB
cord-015021-pol2qm74	2666	7	.	.	.
cord-015021-pol2qm74	2667	1	The	the	DT
cord-015021-pol2qm74	2667	2	above	above	JJ
cord-015021-pol2qm74	2667	3	results	result	NNS
cord-015021-pol2qm74	2667	4	suggest	suggest	VBP
cord-015021-pol2qm74	2667	5	that	that	IN
cord-015021-pol2qm74	2667	6	these	these	DT
cord-015021-pol2qm74	2667	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	2667	8	are	be	VBP
cord-015021-pol2qm74	2667	9	involved	involve	VBN
cord-015021-pol2qm74	2667	10	in	in	IN
cord-015021-pol2qm74	2667	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2667	12	shock	shock	NN
cord-015021-pol2qm74	2667	13	through	through	IN
cord-015021-pol2qm74	2667	14	the	the	DT
cord-015021-pol2qm74	2667	15	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2667	16	that	that	WDT
cord-015021-pol2qm74	2667	17	facilitate	facilitate	VBP
cord-015021-pol2qm74	2667	18	NO	no	DT
cord-015021-pol2qm74	2667	19	production	production	NN
cord-015021-pol2qm74	2667	20	.	.	.
cord-015021-pol2qm74	2668	1	19	19	CD
cord-015021-pol2qm74	2668	2	-	-	SYM
cord-015021-pol2qm74	2668	3	1	1	CD
cord-015021-pol2qm74	2668	4	Uchimaru	Uchimaru	NNP
cord-015021-pol2qm74	2668	5	,	,	,
cord-015021-pol2qm74	2668	6	Morioka	Morioka	NNP
cord-015021-pol2qm74	2668	7	020	020	CD
cord-015021-pol2qm74	2668	8	.	.	.
cord-015021-pol2qm74	2669	1	Japan	Japan	NNP
cord-015021-pol2qm74	2669	2	.	.	.
cord-015021-pol2qm74	2670	1	T.	T.	NNP
cord-015021-pol2qm74	2670	2	Yolk	yolk	NN
cord-015021-pol2qm74	2670	3	1,2	1,2	CD
cord-015021-pol2qm74	2670	4	,	,	,
cord-015021-pol2qm74	2670	5	I.	I.	NNP
cord-015021-pol2qm74	2670	6	Ioannidis	Ioannidis	NNP
cord-015021-pol2qm74	2670	7	1	1	CD
cord-015021-pol2qm74	2670	8	,	,	,
cord-015021-pol2qm74	2670	9	W.J.	W.J.	NNP
cord-015021-pol2qm74	2670	10	Kox	Kox	NNP
cord-015021-pol2qm74	2670	11	2	2	CD
cord-015021-pol2qm74	2670	12	and	and	CC
cord-015021-pol2qm74	2671	1	H.	H.	NNP
cord-015021-pol2qm74	2671	2	de	de	NNP
cord-015021-pol2qm74	2671	3	Groot	Groot	NNP
cord-015021-pol2qm74	2671	4	1	1	CD
cord-015021-pol2qm74	2671	5	Objectives	Objectives	NNPS
cord-015021-pol2qm74	2671	6	:	:	:
cord-015021-pol2qm74	2672	1	Nitric	nitric	NN
cord-015021-pol2qm74	2672	2	Oxide	oxide	NN
cord-015021-pol2qm74	2672	3	(	(	-LRB-
cord-015021-pol2qm74	2672	4	NO	no	UH
cord-015021-pol2qm74	2672	5	.	.	.
cord-015021-pol2qm74	2672	6	)	)	-RRB-
cord-015021-pol2qm74	2672	7	is	be	VBZ
cord-015021-pol2qm74	2672	8	known	know	VBN
cord-015021-pol2qm74	2672	9	to	to	TO
cord-015021-pol2qm74	2672	10	play	play	VB
cord-015021-pol2qm74	2672	11	an	an	DT
cord-015021-pol2qm74	2672	12	important	important	JJ
cord-015021-pol2qm74	2672	13	role	role	NN
cord-015021-pol2qm74	2672	14	in	in	IN
cord-015021-pol2qm74	2672	15	neurotransmission	neurotransmission	NN
cord-015021-pol2qm74	2672	16	,	,	,
cord-015021-pol2qm74	2672	17	vasoregulation	vasoregulation	NN
cord-015021-pol2qm74	2672	18	,	,	,
cord-015021-pol2qm74	2672	19	and	and	CC
cord-015021-pol2qm74	2672	20	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	2672	21	as	as	RB
cord-015021-pol2qm74	2672	22	well	well	RB
cord-015021-pol2qm74	2672	23	as	as	IN
cord-015021-pol2qm74	2672	24	tumoricidal	tumoricidal	NNP
cord-015021-pol2qm74	2672	25	cellular	cellular	JJ
cord-015021-pol2qm74	2672	26	defense	defense	NN
cord-015021-pol2qm74	2672	27	systems	system	NNS
cord-015021-pol2qm74	2672	28	.	.	.
cord-015021-pol2qm74	2673	1	By	by	IN
cord-015021-pol2qm74	2673	2	means	mean	NNS
cord-015021-pol2qm74	2673	3	of	of	IN
cord-015021-pol2qm74	2673	4	NO	no	RB
cord-015021-pol2qm74	2673	5	-	-	HYPH
cord-015021-pol2qm74	2673	6	donating	donate	VBG
cord-015021-pol2qm74	2673	7	agents	agent	NNS
cord-015021-pol2qm74	2673	8	we	-PRON-	PRP
cord-015021-pol2qm74	2673	9	studied	study	VBD
cord-015021-pol2qm74	2673	10	the	the	DT
cord-015021-pol2qm74	2673	11	mechanism	mechanism	NN
cord-015021-pol2qm74	2673	12	of	of	IN
cord-015021-pol2qm74	2673	13	NO	no	RB
cord-015021-pol2qm74	2673	14	-	-	HYPH
cord-015021-pol2qm74	2673	15	mediated	mediate	VBN
cord-015021-pol2qm74	2673	16	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	2673	17	against	against	IN
cord-015021-pol2qm74	2673	18	rat	rat	NN
cord-015021-pol2qm74	2673	19	liver	liver	NN
cord-015021-pol2qm74	2673	20	microvascular	microvascular	JJ
cord-015021-pol2qm74	2673	21	endothelial	endothelial	JJ
cord-015021-pol2qm74	2673	22	cells	cell	NNS
cord-015021-pol2qm74	2673	23	.	.	.
cord-015021-pol2qm74	2674	1	Materials	material	NNS
cord-015021-pol2qm74	2674	2	and	and	CC
cord-015021-pol2qm74	2674	3	methods	method	NNS
cord-015021-pol2qm74	2674	4	:	:	:
cord-015021-pol2qm74	2674	5	3-morphoiinosydnonimine	3-morphoiinosydnonimine	CD
cord-015021-pol2qm74	2674	6	-	-	HYPH
cord-015021-pol2qm74	2674	7	N	N	NNP
cord-015021-pol2qm74	2674	8	-	-	HYPH
cord-015021-pol2qm74	2674	9	ethylcarbamide	ethylcarbamide	NN
cord-015021-pol2qm74	2674	10	(	(	-LRB-
cord-015021-pol2qm74	2674	11	SIN	sin	NN
cord-015021-pol2qm74	2674	12	-	-	HYPH
cord-015021-pol2qm74	2674	13	l	l	NN
cord-015021-pol2qm74	2674	14	)	)	-RRB-
cord-015021-pol2qm74	2674	15	and	and	CC
cord-015021-pol2qm74	2674	16	sodium	sodium	NN
cord-015021-pol2qm74	2674	17	nitroprusside	nitroprusside	NN
cord-015021-pol2qm74	2674	18	(	(	-LRB-
cord-015021-pol2qm74	2674	19	SNP	SNP	NNP
cord-015021-pol2qm74	2674	20	)	)	-RRB-
cord-015021-pol2qm74	2674	21	were	be	VBD
cord-015021-pol2qm74	2674	22	used	use	VBN
cord-015021-pol2qm74	2674	23	as	as	IN
cord-015021-pol2qm74	2674	24	NO	no	RB
cord-015021-pol2qm74	2674	25	.	.	.
cord-015021-pol2qm74	2675	1	donators	donator	NNS
cord-015021-pol2qm74	2675	2	,	,	,
cord-015021-pol2qm74	2675	3	LDH	LDH	NNP
cord-015021-pol2qm74	2675	4	release	release	NN
cord-015021-pol2qm74	2675	5	and	and	CC
cord-015021-pol2qm74	2675	6	trypan	trypan	NNP
cord-015021-pol2qm74	2675	7	blue	blue	JJ
cord-015021-pol2qm74	2675	8	exclusion	exclusion	NN
cord-015021-pol2qm74	2675	9	were	be	VBD
cord-015021-pol2qm74	2675	10	applied	apply	VBN
cord-015021-pol2qm74	2675	11	to	to	TO
cord-015021-pol2qm74	2675	12	indicate	indicate	VB
cord-015021-pol2qm74	2675	13	cell	cell	NN
cord-015021-pol2qm74	2675	14	viability	viability	NN
cord-015021-pol2qm74	2675	15	.	.	.
cord-015021-pol2qm74	2676	1	Results	result	NNS
cord-015021-pol2qm74	2676	2	:	:	:
cord-015021-pol2qm74	2676	3	SIN-1	SIN-1	NNP
cord-015021-pol2qm74	2676	4	(	(	-LRB-
cord-015021-pol2qm74	2676	5	5mM	5mm	CD
cord-015021-pol2qm74	2676	6	)	)	-RRB-
cord-015021-pol2qm74	2676	7	,	,	,
cord-015021-pol2qm74	2676	8	which	which	WDT
cord-015021-pol2qm74	2676	9	releases	release	VBZ
cord-015021-pol2qm74	2676	10	both	both	CC
cord-015021-pol2qm74	2676	11	NO	no	NN
cord-015021-pol2qm74	2676	12	.	.	.
cord-015021-pol2qm74	2676	13	and	and	CC
cord-015021-pol2qm74	2676	14	O2-	o2-	UH
cord-015021-pol2qm74	2676	15	.	.	.
cord-015021-pol2qm74	2676	16	,	,	,
cord-015021-pol2qm74	2676	17	caused	cause	VBD
cord-015021-pol2qm74	2676	18	a	a	DT
cord-015021-pol2qm74	2676	19	time	time	NN
cord-015021-pol2qm74	2676	20	-	-	HYPH
cord-015021-pol2qm74	2676	21	dependent	dependent	JJ
cord-015021-pol2qm74	2676	22	cytoreduction	cytoreduction	NN
cord-015021-pol2qm74	2676	23	of	of	IN
cord-015021-pol2qm74	2676	24	60	60	CD
cord-015021-pol2qm74	2676	25	%	%	NN
cord-015021-pol2qm74	2676	26	and	and	CC
cord-015021-pol2qm74	2676	27	80	80	CD
cord-015021-pol2qm74	2676	28	%	%	NN
cord-015021-pol2qm74	2676	29	after	after	IN
cord-015021-pol2qm74	2676	30	3	3	CD
cord-015021-pol2qm74	2676	31	and	and	CC
cord-015021-pol2qm74	2676	32	6	6	CD
cord-015021-pol2qm74	2676	33	hrs	hrs	NN
cord-015021-pol2qm74	2676	34	,	,	,
cord-015021-pol2qm74	2676	35	respectively	respectively	RB
cord-015021-pol2qm74	2676	36	.	.	.
cord-015021-pol2qm74	2677	1	This	this	DT
cord-015021-pol2qm74	2677	2	effect	effect	NN
cord-015021-pol2qm74	2677	3	was	be	VBD
cord-015021-pol2qm74	2677	4	not	not	RB
cord-015021-pol2qm74	2677	5	inhibited	inhibit	VBN
cord-015021-pol2qm74	2677	6	by	by	IN
cord-015021-pol2qm74	2677	7	superoxide	superoxide	NN
cord-015021-pol2qm74	2677	8	dismutase	dismutase	NN
cord-015021-pol2qm74	2677	9	(	(	-LRB-
cord-015021-pol2qm74	2677	10	SOD	SOD	NNP
cord-015021-pol2qm74	2677	11	)	)	-RRB-
cord-015021-pol2qm74	2677	12	,	,	,
cord-015021-pol2qm74	2677	13	which	which	WDT
cord-015021-pol2qm74	2677	14	removes	remove	VBZ
cord-015021-pol2qm74	2677	15	02	02	CD
cord-015021-pol2qm74	2677	16	-	-	SYM
cord-015021-pol2qm74	2677	17	-to	-to	JJS
cord-015021-pol2qm74	2677	18	form	form	NN
cord-015021-pol2qm74	2677	19	H202	h202	NN
cord-015021-pol2qm74	2677	20	and	and	CC
cord-015021-pol2qm74	2677	21	02	02	CD
cord-015021-pol2qm74	2677	22	.	.	.
cord-015021-pol2qm74	2678	1	In	in	IN
cord-015021-pol2qm74	2678	2	contrast	contrast	NN
cord-015021-pol2qm74	2678	3	,	,	,
cord-015021-pol2qm74	2678	4	the	the	DT
cord-015021-pol2qm74	2678	5	addition	addition	NN
cord-015021-pol2qm74	2678	6	of	of	IN
cord-015021-pol2qm74	2678	7	catalase	catalase	NN
cord-015021-pol2qm74	2678	8	(	(	-LRB-
cord-015021-pol2qm74	2678	9	CAT	CAT	NNP
cord-015021-pol2qm74	2678	10	)	)	-RRB-
cord-015021-pol2qm74	2678	11	,	,	,
cord-015021-pol2qm74	2678	12	which	which	WDT
cord-015021-pol2qm74	2678	13	removes	remove	VBZ
cord-015021-pol2qm74	2678	14	H202	h202	NN
cord-015021-pol2qm74	2678	15	to	to	TO
cord-015021-pol2qm74	2678	16	form	form	VB
cord-015021-pol2qm74	2678	17	H20	H20	NNP
cord-015021-pol2qm74	2678	18	and	and	CC
cord-015021-pol2qm74	2678	19	02	02	CD
cord-015021-pol2qm74	2678	20	,	,	,
cord-015021-pol2qm74	2678	21	diminished	diminish	VBD
cord-015021-pol2qm74	2678	22	the	the	DT
cord-015021-pol2qm74	2678	23	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	2678	24	effect	effect	NN
cord-015021-pol2qm74	2678	25	ot	ot	NN
cord-015021-pol2qm74	2678	26	SIN-1	SIN-1	NNP
cord-015021-pol2qm74	2678	27	to	to	IN
cord-015021-pol2qm74	2678	28	30	30	CD
cord-015021-pol2qm74	2678	29	%	%	NN
cord-015021-pol2qm74	2678	30	,	,	,
cord-015021-pol2qm74	2678	31	equivalent	equivalent	JJ
cord-015021-pol2qm74	2678	32	to	to	IN
cord-015021-pol2qm74	2678	33	high	high	JJ
cord-015021-pol2qm74	2678	34	concentrations	concentration	NNS
cord-015021-pol2qm74	2678	35	of	of	IN
cord-015021-pol2qm74	2678	36	SNP	SNP	NNP
cord-015021-pol2qm74	2678	37	(	(	-LRB-
cord-015021-pol2qm74	2678	38	20mM	20mm	CD
cord-015021-pol2qm74	2678	39	)	)	-RRB-
cord-015021-pol2qm74	2678	40	,	,	,
cord-015021-pol2qm74	2678	41	which	which	WDT
cord-015021-pol2qm74	2678	42	solely	solely	RB
cord-015021-pol2qm74	2678	43	releases	release	VBZ
cord-015021-pol2qm74	2678	44	NO	no	DT
cord-015021-pol2qm74	2678	45	..	..	.
cord-015021-pol2qm74	2679	1	In	in	IN
cord-015021-pol2qm74	2679	2	addition	addition	NN
cord-015021-pol2qm74	2679	3	,	,	,
cord-015021-pol2qm74	2679	4	the	the	DT
cord-015021-pol2qm74	2679	5	amount	amount	NN
cord-015021-pol2qm74	2679	6	of	of	IN
cord-015021-pol2qm74	2679	7	H202	h202	NN
cord-015021-pol2qm74	2679	8	formed	form	VBN
cord-015021-pol2qm74	2679	9	by	by	IN
cord-015021-pol2qm74	2679	10	5mM	5mm	CD
cord-015021-pol2qm74	2679	11	SIN-1	SIN-1	NNP
cord-015021-pol2qm74	2679	12	equaled	equal	VBD
cord-015021-pol2qm74	2679	13	the	the	DT
cord-015021-pol2qm74	2679	14	amount	amount	NN
cord-015021-pol2qm74	2679	15	ot	ot	NNP
cord-015021-pol2qm74	2679	16	enzymaticany	enzymaticany	NNP
cord-015021-pol2qm74	2679	17	produced	produce	VBD
cord-015021-pol2qm74	2679	18	H202	h202	NN
cord-015021-pol2qm74	2679	19	by	by	IN
cord-015021-pol2qm74	2679	20	5mU	5mu	CD
cord-015021-pol2qm74	2679	21	/	/	SYM
cord-015021-pol2qm74	2679	22	L	l	NN
cord-015021-pol2qm74	2679	23	glucose	glucose	NN
cord-015021-pol2qm74	2679	24	oxidase	oxidase	NN
cord-015021-pol2qm74	2679	25	(	(	-LRB-
cord-015021-pol2qm74	2679	26	GOD	GOD	NNP
cord-015021-pol2qm74	2679	27	)	)	-RRB-
cord-015021-pol2qm74	2679	28	.	.	.
cord-015021-pol2qm74	2680	1	Whereas	whereas	IN
cord-015021-pol2qm74	2680	2	GOD	GOD	NNP
cord-015021-pol2qm74	2680	3	in	in	IN
cord-015021-pol2qm74	2680	4	this	this	DT
cord-015021-pol2qm74	2680	5	concentration	concentration	NN
cord-015021-pol2qm74	2680	6	and	and	CC
cord-015021-pol2qm74	2680	7	SNP	SNP	NNP
cord-015021-pol2qm74	2680	8	in	in	IN
cord-015021-pol2qm74	2680	9	low	low	JJ
cord-015021-pol2qm74	2680	10	concentration	concentration	NN
cord-015021-pol2qm74	2680	11	(	(	-LRB-
cord-015021-pol2qm74	2680	12	5mM	5mm	CD
cord-015021-pol2qm74	2680	13	)	)	-RRB-
cord-015021-pol2qm74	2680	14	alone	alone	RB
cord-015021-pol2qm74	2680	15	were	be	VBD
cord-015021-pol2qm74	2680	16	not	not	RB
cord-015021-pol2qm74	2680	17	toxic	toxic	JJ
cord-015021-pol2qm74	2680	18	to	to	IN
cord-015021-pol2qm74	2680	19	endothelial	endothelial	JJ
cord-015021-pol2qm74	2680	20	cells	cell	NNS
cord-015021-pol2qm74	2680	21	,	,	,
cord-015021-pol2qm74	2680	22	the	the	DT
cord-015021-pol2qm74	2680	23	combination	combination	NN
cord-015021-pol2qm74	2680	24	caused	cause	VBD
cord-015021-pol2qm74	2680	25	an	an	DT
cord-015021-pol2qm74	2680	26	80	80	CD
cord-015021-pol2qm74	2680	27	%	%	NN
cord-015021-pol2qm74	2680	28	reduction	reduction	NN
cord-015021-pol2qm74	2680	29	of	of	IN
cord-015021-pol2qm74	2680	30	viability	viability	NN
cord-015021-pol2qm74	2680	31	,	,	,
cord-015021-pol2qm74	2680	32	comparable	comparable	JJ
cord-015021-pol2qm74	2680	33	to	to	IN
cord-015021-pol2qm74	2680	34	the	the	DT
cord-015021-pol2qm74	2680	35	effect	effect	NN
cord-015021-pol2qm74	2680	36	observed	observe	VBN
cord-015021-pol2qm74	2680	37	with	with	IN
cord-015021-pol2qm74	2680	38	SIN-1	SIN-1	NNP
cord-015021-pol2qm74	2680	39	(	(	-LRB-
cord-015021-pol2qm74	2680	40	5mM	5mm	CD
cord-015021-pol2qm74	2680	41	)	)	-RRB-
cord-015021-pol2qm74	2680	42	alone	alone	RB
cord-015021-pol2qm74	2680	43	.	.	.
cord-015021-pol2qm74	2681	1	Moreover	moreover	RB
cord-015021-pol2qm74	2681	2	,	,	,
cord-015021-pol2qm74	2681	3	toxicity	toxicity	NN
cord-015021-pol2qm74	2681	4	mediated	mediate	VBN
cord-015021-pol2qm74	2681	5	by	by	IN
cord-015021-pol2qm74	2681	6	high	high	JJ
cord-015021-pol2qm74	2681	7	concentrations	concentration	NNS
cord-015021-pol2qm74	2681	8	of	of	IN
cord-015021-pol2qm74	2681	9	SNP	SNP	NNP
cord-015021-pol2qm74	2681	10	(	(	-LRB-
cord-015021-pol2qm74	2681	11	20mM	20mm	CD
cord-015021-pol2qm74	2681	12	and	and	CC
cord-015021-pol2qm74	2681	13	50raM	50ram	CD
cord-015021-pol2qm74	2681	14	)	)	-RRB-
cord-015021-pol2qm74	2681	15	was	be	VBD
cord-015021-pol2qm74	2681	16	reduced	reduce	VBN
cord-015021-pol2qm74	2681	17	by	by	IN
cord-015021-pol2qm74	2681	18	20	20	CD
cord-015021-pol2qm74	2681	19	%	%	NN
cord-015021-pol2qm74	2681	20	under	under	IN
cord-015021-pol2qm74	2681	21	hypoxic	hypoxic	JJ
cord-015021-pol2qm74	2681	22	conditions	condition	NNS
cord-015021-pol2qm74	2681	23	indicating	indicate	VBG
cord-015021-pol2qm74	2681	24	synergism	synergism	NN
cord-015021-pol2qm74	2681	25	with	with	IN
cord-015021-pol2qm74	2681	26	NO	no	NN
cord-015021-pol2qm74	2681	27	-	-	HYPH
cord-015021-pol2qm74	2681	28	and	and	CC
cord-015021-pol2qm74	2681	29	02	02	CD
cord-015021-pol2qm74	2681	30	.	.	.
cord-015021-pol2qm74	2682	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	2682	2	:	:	:
cord-015021-pol2qm74	2683	1	We	-PRON-	PRP
cord-015021-pol2qm74	2683	2	conclude	conclude	VBP
cord-015021-pol2qm74	2683	3	,	,	,
cord-015021-pol2qm74	2683	4	that	that	IN
cord-015021-pol2qm74	2683	5	NO.-induced	no.-induced	JJ
cord-015021-pol2qm74	2683	6	toxicity	toxicity	NN
cord-015021-pol2qm74	2683	7	against	against	IN
cord-015021-pol2qm74	2683	8	endothelial	endothelial	JJ
cord-015021-pol2qm74	2683	9	cells	cell	NNS
cord-015021-pol2qm74	2683	10	is	be	VBZ
cord-015021-pol2qm74	2683	11	enhanced	enhance	VBN
cord-015021-pol2qm74	2683	12	slightly	slightly	RB
cord-015021-pol2qm74	2683	13	in	in	IN
cord-015021-pol2qm74	2683	14	the	the	DT
cord-015021-pol2qm74	2683	15	presence	presence	NN
cord-015021-pol2qm74	2683	16	of	of	IN
cord-015021-pol2qm74	2683	17	oxygen	oxygen	NN
cord-015021-pol2qm74	2683	18	and	and	CC
cord-015021-pol2qm74	2683	19	is	be	VBZ
cord-015021-pol2qm74	2683	20	not	not	RB
cord-015021-pol2qm74	2683	21	due	due	JJ
cord-015021-pol2qm74	2683	22	to	to	IN
cord-015021-pol2qm74	2683	23	an	an	DT
cord-015021-pol2qm74	2683	24	interaction	interaction	NN
cord-015021-pol2qm74	2683	25	with	with	IN
cord-015021-pol2qm74	2683	26	02-	02-	NNP
cord-015021-pol2qm74	2683	27	.	.	.
cord-015021-pol2qm74	2684	1	However	however	RB
cord-015021-pol2qm74	2684	2	,	,	,
cord-015021-pol2qm74	2684	3	toxicity	toxicity	NN
cord-015021-pol2qm74	2684	4	increases	increase	NNS
cord-015021-pol2qm74	2684	5	dramatically	dramatically	RB
cord-015021-pol2qm74	2684	6	in	in	IN
cord-015021-pol2qm74	2684	7	the	the	DT
cord-015021-pol2qm74	2684	8	presence	presence	NN
cord-015021-pol2qm74	2684	9	of	of	IN
cord-015021-pol2qm74	2684	10	H202	H202	NNP
cord-015021-pol2qm74	2684	11	.	.	.
cord-015021-pol2qm74	2685	1	This	this	DT
cord-015021-pol2qm74	2685	2	may	may	MD
cord-015021-pol2qm74	2685	3	possibly	possibly	RB
cord-015021-pol2qm74	2685	4	occur	occur	VB
cord-015021-pol2qm74	2685	5	either	either	RB
cord-015021-pol2qm74	2685	6	by	by	IN
cord-015021-pol2qm74	2685	7	a	a	DT
cord-015021-pol2qm74	2685	8	chemical	chemical	JJ
cord-015021-pol2qm74	2685	9	formation	formation	NN
cord-015021-pol2qm74	2685	10	of	of	IN
cord-015021-pol2qm74	2685	11	more	more	RBR
cord-015021-pol2qm74	2685	12	potent	potent	JJ
cord-015021-pol2qm74	2685	13	reactive	reactive	JJ
cord-015021-pol2qm74	2685	14	hydroxyl	hydroxyl	NN
cord-015021-pol2qm74	2685	15	radicals	radical	NNS
cord-015021-pol2qm74	2685	16	or	or	CC
cord-015021-pol2qm74	2685	17	by	by	IN
cord-015021-pol2qm74	2685	18	independent	independent	JJ
cord-015021-pol2qm74	2685	19	actions	action	NNS
cord-015021-pol2qm74	2685	20	on	on	IN
cord-015021-pol2qm74	2685	21	different	different	JJ
cord-015021-pol2qm74	2685	22	cellular	cellular	JJ
cord-015021-pol2qm74	2685	23	targets	target	NNS
cord-015021-pol2qm74	2685	24	.	.	.
cord-015021-pol2qm74	2685	25	 	 	_SP
cord-015021-pol2qm74	2686	1	Although	although	IN
cord-015021-pol2qm74	2686	2	it	-PRON-	PRP
cord-015021-pol2qm74	2686	3	is	be	VBZ
cord-015021-pol2qm74	2686	4	becoming	become	VBG
cord-015021-pol2qm74	2686	5	increasingly	increasingly	RB
cord-015021-pol2qm74	2686	6	clear	clear	JJ
cord-015021-pol2qm74	2686	7	that	that	IN
cord-015021-pol2qm74	2686	8	Nitric	nitric	NN
cord-015021-pol2qm74	2686	9	Oxide	oxide	NN
cord-015021-pol2qm74	2686	10	(	(	-LRB-
cord-015021-pol2qm74	2686	11	NO	no	UH
cord-015021-pol2qm74	2686	12	)	)	-RRB-
cord-015021-pol2qm74	2686	13	is	be	VBZ
cord-015021-pol2qm74	2686	14	associated	associate	VBN
cord-015021-pol2qm74	2686	15	with	with	IN
cord-015021-pol2qm74	2686	16	otxan	otxan	JJ
cord-015021-pol2qm74	2686	17	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	2686	18	in	in	IN
cord-015021-pol2qm74	2686	19	septic	septic	JJ
cord-015021-pol2qm74	2686	20	patients	patient	NNS
cord-015021-pol2qm74	2686	21	,	,	,
cord-015021-pol2qm74	2686	22	little	little	JJ
cord-015021-pol2qm74	2686	23	is	be	VBZ
cord-015021-pol2qm74	2686	24	known	know	VBN
cord-015021-pol2qm74	2686	25	as	as	IN
cord-015021-pol2qm74	2686	26	to	to	TO
cord-015021-pol2qm74	2686	27	die	die	VB
cord-015021-pol2qm74	2686	28	kinetics	kinetic	NNS
cord-015021-pol2qm74	2686	29	of	of	IN
cord-015021-pol2qm74	2686	30	NO	no	DT
cord-015021-pol2qm74	2686	31	production	production	NN
cord-015021-pol2qm74	2686	32	in	in	IN
cord-015021-pol2qm74	2686	33	these	these	DT
cord-015021-pol2qm74	2686	34	patients	patient	NNS
cord-015021-pol2qm74	2686	35	To	to	TO
cord-015021-pol2qm74	2686	36	clarify	clarify	VB
cord-015021-pol2qm74	2686	37	these	these	DT
cord-015021-pol2qm74	2686	38	kinetics	kinetic	NNS
cord-015021-pol2qm74	2686	39	,	,	,
cord-015021-pol2qm74	2686	40	we	-PRON-	PRP
cord-015021-pol2qm74	2686	41	have	have	VBP
cord-015021-pol2qm74	2686	42	investegated	investegate	VBN
cord-015021-pol2qm74	2686	43	serum	serum	NN
cord-015021-pol2qm74	2686	44	arid	arid	JJ
cord-015021-pol2qm74	2686	45	monocyte	monocyte	NNP
cord-015021-pol2qm74	2686	46	associated	associate	VBD
cord-015021-pol2qm74	2686	47	NO	no	RB
cord-015021-pol2qm74	2686	48	in	in	IN
cord-015021-pol2qm74	2686	49	septic	septic	JJ
cord-015021-pol2qm74	2686	50	patients	patient	NNS
cord-015021-pol2qm74	2686	51	.	.	.
cord-015021-pol2qm74	2687	1	Five	five	CD
cord-015021-pol2qm74	2687	2	patients	patient	NNS
cord-015021-pol2qm74	2687	3	who	who	WP
cord-015021-pol2qm74	2687	4	had	have	VBD
cord-015021-pol2qm74	2687	5	undergone	undergo	VBN
cord-015021-pol2qm74	2687	6	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	2687	7	surgeries	surgery	NNS
cord-015021-pol2qm74	2687	8	mid	mid	NNP
cord-015021-pol2qm74	2687	9	were	be	VBD
cord-015021-pol2qm74	2687	10	complicated	complicated	JJ
cord-015021-pol2qm74	2687	11	postoperatively	postoperatively	RB
cord-015021-pol2qm74	2687	12	with	with	IN
cord-015021-pol2qm74	2687	13	severe	severe	JJ
cord-015021-pol2qm74	2687	14	sepsis	sepsis	NN
cord-015021-pol2qm74	2687	15	served	serve	VBD
cord-015021-pol2qm74	2687	16	as	as	IN
cord-015021-pol2qm74	2687	17	the	the	DT
cord-015021-pol2qm74	2687	18	subjects	subject	NNS
cord-015021-pol2qm74	2687	19	in	in	IN
cord-015021-pol2qm74	2687	20	this	this	DT
cord-015021-pol2qm74	2687	21	study	study	NN
cord-015021-pol2qm74	2687	22	(	(	-LRB-
cord-015021-pol2qm74	2687	23	Sgroup	Sgroup	NNP
cord-015021-pol2qm74	2687	24	)	)	-RRB-
cord-015021-pol2qm74	2687	25	,	,	,
cord-015021-pol2qm74	2687	26	using	use	VBG
cord-015021-pol2qm74	2687	27	twelve	twelve	CD
cord-015021-pol2qm74	2687	28	healthy	healthy	JJ
cord-015021-pol2qm74	2687	29	volunteers	volunteer	NNS
cord-015021-pol2qm74	2687	30	as	as	IN
cord-015021-pol2qm74	2687	31	a	a	DT
cord-015021-pol2qm74	2687	32	control	control	NN
cord-015021-pol2qm74	2687	33	group	group	NN
cord-015021-pol2qm74	2687	34	(	(	-LRB-
cord-015021-pol2qm74	2687	35	C	C	NNP
cord-015021-pol2qm74	2687	36	group	group	NN
cord-015021-pol2qm74	2687	37	)	)	-RRB-
cord-015021-pol2qm74	2687	38	.	.	.
cord-015021-pol2qm74	2688	1	Serum	serum	NN
cord-015021-pol2qm74	2688	2	NO2	NO2	NNP
cord-015021-pol2qm74	2688	3	and	and	CC
cord-015021-pol2qm74	2688	4	NO3	NO3	NNP
cord-015021-pol2qm74	2688	5	levels	level	NNS
cord-015021-pol2qm74	2688	6	were	be	VBD
cord-015021-pol2qm74	2688	7	measul*d	measul*d	NNP
cord-015021-pol2qm74	2688	8	sliectrophotometricallyMonocyte	sliectrophotometricallyMonocyte	NNP
cord-015021-pol2qm74	2688	9	cultures	culture	NNS
cord-015021-pol2qm74	2688	10	were	be	VBD
cord-015021-pol2qm74	2688	11	done	do	VBN
cord-015021-pol2qm74	2688	12	for	for	IN
cord-015021-pol2qm74	2688	13	24	24	CD
cord-015021-pol2qm74	2688	14	Itrs	Itrs	NNP
cord-015021-pol2qm74	2688	15	with	with	IN
cord-015021-pol2qm74	2688	16	or	or	CC
cord-015021-pol2qm74	2688	17	without	without	IN
cord-015021-pol2qm74	2688	18	LPS+IFN	lps+ifn	NN
cord-015021-pol2qm74	2688	19	-	-	HYPH
cord-015021-pol2qm74	2688	20	T	t	NN
cord-015021-pol2qm74	2688	21	stimulation	stimulation	NN
cord-015021-pol2qm74	2688	22	mid	mid	IN
cord-015021-pol2qm74	2688	23	NO2	NO2	NNP
cord-015021-pol2qm74	2688	24	and	and	CC
cord-015021-pol2qm74	2688	25	NO3	NO3	NNP
cord-015021-pol2qm74	2688	26	levels	level	NNS
cord-015021-pol2qm74	2688	27	in	in	IN
cord-015021-pol2qm74	2688	28	the	the	DT
cord-015021-pol2qm74	2688	29	supernat,'utts	supernat,'utts	NN
cord-015021-pol2qm74	2688	30	were	be	VBD
cord-015021-pol2qm74	2688	31	also	also	RB
cord-015021-pol2qm74	2688	32	measured	measure	VBN
cord-015021-pol2qm74	2688	33	spectrophotometrically	spectrophotometrically	RB
cord-015021-pol2qm74	2688	34	.	.	.
cord-015021-pol2qm74	2689	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2689	2	,	,	,
cord-015021-pol2qm74	2689	3	using	use	VBG
cord-015021-pol2qm74	2689	4	an	an	DT
cord-015021-pol2qm74	2689	5	NO	no	DT
cord-015021-pol2qm74	2689	6	selective	selective	JJ
cord-015021-pol2qm74	2689	7	electrode	electrode	NN
cord-015021-pol2qm74	2689	8	,	,	,
cord-015021-pol2qm74	2689	9	time	time	NN
cord-015021-pol2qm74	2689	10	course	course	NN
cord-015021-pol2qm74	2689	11	of	of	IN
cord-015021-pol2qm74	2689	12	the	the	DT
cord-015021-pol2qm74	2689	13	LPS+IFN	LPS+IFN	NNP
cord-015021-pol2qm74	2689	14	-	-	HYPH
cord-015021-pol2qm74	2689	15	T	T	NNP
cord-015021-pol2qm74	2689	16	induced	induce	VBD
cord-015021-pol2qm74	2689	17	NO	no	DT
cord-015021-pol2qm74	2689	18	production	production	NN
cord-015021-pol2qm74	2689	19	by	by	IN
cord-015021-pol2qm74	2689	20	monocytes	monocyte	NNS
cord-015021-pol2qm74	2689	21	was	be	VBD
cord-015021-pol2qm74	2689	22	studied	study	VBN
cord-015021-pol2qm74	2689	23	.	.	.
cord-015021-pol2qm74	2690	1	l	l	LS
cord-015021-pol2qm74	2690	2	)	)	-RRB-
cord-015021-pol2qm74	2690	3	Serum	serum	NN
cord-015021-pol2qm74	2690	4	NO2	NO2	NNP
cord-015021-pol2qm74	2690	5	levels	level	NNS
cord-015021-pol2qm74	2690	6	in	in	IN
cord-015021-pol2qm74	2690	7	S	S	NNP
cord-015021-pol2qm74	2690	8	group	group	NN
cord-015021-pol2qm74	2690	9	were	be	VBD
cord-015021-pol2qm74	2690	10	slightly	slightly	RB
cord-015021-pol2qm74	2690	11	lfigher	lfigh	JJR
cord-015021-pol2qm74	2690	12	than	than	IN
cord-015021-pol2qm74	2690	13	dmse	dmse	NNP
cord-015021-pol2qm74	2690	14	in	in	IN
cord-015021-pol2qm74	2690	15	C	C	NNP
cord-015021-pol2qm74	2690	16	group	group	NN
cord-015021-pol2qm74	2690	17	,	,	,
cord-015021-pol2qm74	2690	18	bnt	bnt	VBP
cord-015021-pol2qm74	2690	19	there	there	EX
cord-015021-pol2qm74	2690	20	were	be	VBD
cord-015021-pol2qm74	2690	21	no	no	DT
cord-015021-pol2qm74	2690	22	significoatt	significoatt	JJ
cord-015021-pol2qm74	2690	23	differences	difference	NNS
cord-015021-pol2qm74	2690	24	between	between	IN
cord-015021-pol2qm74	2690	25	the	the	DT
cord-015021-pol2qm74	2690	26	two	two	CD
cord-015021-pol2qm74	2690	27	.	.	.
cord-015021-pol2qm74	2691	1	2)Both	2)both	CD
cord-015021-pol2qm74	2691	2	NO2	NO2	NNP
cord-015021-pol2qm74	2691	3	levels	level	NNS
cord-015021-pol2qm74	2691	4	in	in	IN
cord-015021-pol2qm74	2691	5	the	the	DT
cord-015021-pol2qm74	2691	6	supematmlts	supematmlts	NN
cord-015021-pol2qm74	2691	7	of	of	IN
cord-015021-pol2qm74	2691	8	monocytes	monocyte	NNS
cord-015021-pol2qm74	2691	9	cultured	culture	VBN
cord-015021-pol2qm74	2691	10	with	with	IN
cord-015021-pol2qm74	2691	11	LPS+IFN	LPS+IFN	NNP
cord-015021-pol2qm74	2691	12	-	-	HYPH
cord-015021-pol2qm74	2691	13	T	T	NNP
cord-015021-pol2qm74	2691	14	mid	mid	NN
cord-015021-pol2qm74	2691	15	NO2	NO2	NNP
cord-015021-pol2qm74	2691	16	,	,	,
cord-015021-pol2qm74	2691	17	NO3	NO3	NNP
cord-015021-pol2qm74	2691	18	levels	level	NNS
cord-015021-pol2qm74	2692	1	ill	ill	NNP
cord-015021-pol2qm74	2692	2	lhe	lhe	NNP
cord-015021-pol2qm74	2692	3	supernatants	supernatant	NNS
cord-015021-pol2qm74	2692	4	of	of	IN
cord-015021-pol2qm74	2692	5	monocytes	monocyte	NNS
cord-015021-pol2qm74	2692	6	cultured	culture	VBN
cord-015021-pol2qm74	2692	7	without	without	IN
cord-015021-pol2qm74	2692	8	LPS+IFN	LPS+IFN	NNP
cord-015021-pol2qm74	2692	9	-	-	HYPH
cord-015021-pol2qm74	2692	10	Y	Y	NNP
cord-015021-pol2qm74	2692	11	were	be	VBD
cord-015021-pol2qm74	2692	12	significantly	significantly	RB
cord-015021-pol2qm74	2692	13	higher	high	JJR
cord-015021-pol2qm74	2692	14	in	in	IN
cord-015021-pol2qm74	2692	15	S	S	NNP
cord-015021-pol2qm74	2692	16	group	group	NN
cord-015021-pol2qm74	2692	17	.	.	.
cord-015021-pol2qm74	2693	1	Further	further	RB
cord-015021-pol2qm74	2693	2	,	,	,
cord-015021-pol2qm74	2693	3	the	the	DT
cord-015021-pol2qm74	2693	4	time	time	NN
cord-015021-pol2qm74	2693	5	required	require	VBN
cord-015021-pol2qm74	2693	6	for	for	IN
cord-015021-pol2qm74	2693	7	the	the	DT
cord-015021-pol2qm74	2693	8	NO	no	JJ
cord-015021-pol2qm74	2693	9	production	production	NN
cord-015021-pol2qm74	2693	10	by	by	IN
cord-015021-pol2qm74	2693	11	enltnred	enltnred	NNP
cord-015021-pol2qm74	2693	12	monoeytes	monoeytes	NNPS
cord-015021-pol2qm74	2693	13	was	be	VBD
cord-015021-pol2qm74	2693	14	siglfificantly	siglfificantly	RB
cord-015021-pol2qm74	2693	15	shorter	short	JJR
cord-015021-pol2qm74	2693	16	also	also	RB
cord-015021-pol2qm74	2693	17	in	in	IN
cord-015021-pol2qm74	2693	18	S	S	NNP
cord-015021-pol2qm74	2693	19	groap	groap	NN
cord-015021-pol2qm74	2693	20	.	.	.
cord-015021-pol2qm74	2694	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	2694	2	l)In	l)In	VBD
cord-015021-pol2qm74	2694	3	severe	severe	JJ
cord-015021-pol2qm74	2694	4	septic	septic	JJ
cord-015021-pol2qm74	2694	5	patients	patient	NNS
cord-015021-pol2qm74	2694	6	,	,	,
cord-015021-pol2qm74	2694	7	monocyte	monocyte	NNP
cord-015021-pol2qm74	2694	8	NO	NO	NNP
cord-015021-pol2qm74	2694	9	productions	production	NNS
cord-015021-pol2qm74	2695	1	wei~	wei~	NNP
cord-015021-pol2qm74	2695	2	not	not	RB
cord-015021-pol2qm74	2695	3	only	only	RB
cord-015021-pol2qm74	2695	4	primed	prime	VBN
cord-015021-pol2qm74	2695	5	,	,	,
cord-015021-pol2qm74	2695	6	but	but	CC
cord-015021-pol2qm74	2695	7	also	also	RB
cord-015021-pol2qm74	2695	8	activated	activate	VBN
cord-015021-pol2qm74	2695	9	concomitantly	concomitantly	RB
cord-015021-pol2qm74	2695	10	,	,	,
cord-015021-pol2qm74	2695	11	suggesting	suggest	VBG
cord-015021-pol2qm74	2695	12	that	that	IN
cord-015021-pol2qm74	2695	13	these	these	DT
cord-015021-pol2qm74	2695	14	monocyte	monocyte	NNP
cord-015021-pol2qm74	2695	15	activations	activation	NNS
cord-015021-pol2qm74	2695	16	m'e	m'e	RB
cord-015021-pol2qm74	2695	17	strongly	strongly	RB
cord-015021-pol2qm74	2695	18	associated	associate	VBN
cord-015021-pol2qm74	2695	19	with	with	IN
cord-015021-pol2qm74	2695	20	organ	organ	NN
cord-015021-pol2qm74	2695	21	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	2695	22	in	in	IN
cord-015021-pol2qm74	2695	23	sepsis	sepsis	NN
cord-015021-pol2qm74	2695	24	.	.	.
cord-015021-pol2qm74	2696	1	2)Based	2)based	CD
cord-015021-pol2qm74	2696	2	on	on	IN
cord-015021-pol2qm74	2696	3	the	the	DT
cord-015021-pol2qm74	2696	4	restdts	restdts	NNP
cord-015021-pol2qm74	2696	5	of	of	IN
cord-015021-pol2qm74	2696	6	serum	serum	NN
cord-015021-pol2qm74	2696	7	NO	no	DT
cord-015021-pol2qm74	2696	8	nteasuremeuts	nteasuremeut	NNS
cord-015021-pol2qm74	2696	9	,	,	,
cord-015021-pol2qm74	2696	10	it	-PRON-	PRP
cord-015021-pol2qm74	2696	11	can	can	MD
cord-015021-pol2qm74	2696	12	be	be	VB
cord-015021-pol2qm74	2696	13	deduced	deduce	VBN
cord-015021-pol2qm74	2696	14	that	that	IN
cord-015021-pol2qm74	2696	15	NO	no	DT
cord-015021-pol2qm74	2696	16	p~'oduced	p~'oduce	VBN
cord-015021-pol2qm74	2696	17	by	by	IN
cord-015021-pol2qm74	2696	18	monocytes	monocyte	NNS
cord-015021-pol2qm74	2696	19	in	in	IN
cord-015021-pol2qm74	2696	20	septic	septic	JJ
cord-015021-pol2qm74	2696	21	patients	patient	NNS
cord-015021-pol2qm74	2696	22	affects	affect	VBZ
cord-015021-pol2qm74	2696	23	tissues	tissue	NNS
cord-015021-pol2qm74	2696	24	and	and	CC
cord-015021-pol2qm74	2696	25	org	org	NN
cord-015021-pol2qm74	2696	26	~	~	NNP
cord-015021-pol2qm74	2696	27	s	s	XX
cord-015021-pol2qm74	2696	28	Ioeoregiomflly	Ioeoregiomflly	NNP
cord-015021-pol2qm74	2696	29	.	.	.
cord-015021-pol2qm74	2697	1	Objectives	objective	NNS
cord-015021-pol2qm74	2697	2	of	of	IN
cord-015021-pol2qm74	2697	3	the	the	DT
cord-015021-pol2qm74	2697	4	study	study	NN
cord-015021-pol2qm74	2697	5	:	:	:
cord-015021-pol2qm74	2697	6	Nitric	nitric	NN
cord-015021-pol2qm74	2697	7	Oxide	oxide	NN
cord-015021-pol2qm74	2697	8	(	(	-LRB-
cord-015021-pol2qm74	2697	9	NO	no	UH
cord-015021-pol2qm74	2697	10	)	)	-RRB-
cord-015021-pol2qm74	2697	11	is	be	VBZ
cord-015021-pol2qm74	2697	12	an	an	DT
cord-015021-pol2qm74	2697	13	important	important	JJ
cord-015021-pol2qm74	2697	14	messenger	messenger	NN
cord-015021-pol2qm74	2697	15	which	which	WDT
cord-015021-pol2qm74	2697	16	accounts	account	VBZ
cord-015021-pol2qm74	2697	17	for	for	IN
cord-015021-pol2qm74	2697	18	a	a	DT
cord-015021-pol2qm74	2697	19	wide	wide	JJ
cord-015021-pol2qm74	2697	20	spectrum	spectrum	NN
cord-015021-pol2qm74	2697	21	of	of	IN
cord-015021-pol2qm74	2697	22	physiological	physiological	JJ
cord-015021-pol2qm74	2697	23	and	and	CC
cord-015021-pol2qm74	2697	24	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	2697	25	processes	process	NNS
cord-015021-pol2qm74	2697	26	,	,	,
cord-015021-pol2qm74	2697	27	e.g.	e.g.	RB
cord-015021-pol2qm74	2697	28	mediating	mediate	VBG
cord-015021-pol2qm74	2697	29	vasodilation	vasodilation	NN
cord-015021-pol2qm74	2697	30	in	in	IN
cord-015021-pol2qm74	2697	31	endoloxin	endoloxin	NN
cord-015021-pol2qm74	2697	32	shock	shock	NN
cord-015021-pol2qm74	2697	33	Investigating	investigate	VBG
cord-015021-pol2qm74	2697	34	the	the	DT
cord-015021-pol2qm74	2697	35	signal	signal	NN
cord-015021-pol2qm74	2697	36	lransducfion	lransducfion	NN
cord-015021-pol2qm74	2697	37	pathways	pathway	NNS
cord-015021-pol2qm74	2697	38	involved	involve	VBN
cord-015021-pol2qm74	2697	39	in	in	IN
cord-015021-pol2qm74	2697	40	the	the	DT
cord-015021-pol2qm74	2697	41	regulation	regulation	NN
cord-015021-pol2qm74	2697	42	of	of	IN
cord-015021-pol2qm74	2697	43	the	the	DT
cord-015021-pol2qm74	2697	44	inducible	inducible	JJ
cord-015021-pol2qm74	2697	45	nitric	nitric	NN
cord-015021-pol2qm74	2697	46	oxide	oxide	NN
cord-015021-pol2qm74	2697	47	synthase	synthase	NN
cord-015021-pol2qm74	2697	48	(	(	-LRB-
cord-015021-pol2qm74	2697	49	iNOS	inos	NN
cord-015021-pol2qm74	2697	50	)	)	-RRB-
cord-015021-pol2qm74	2697	51	,	,	,
cord-015021-pol2qm74	2697	52	we	-PRON-	PRP
cord-015021-pol2qm74	2697	53	report	report	VBP
cord-015021-pol2qm74	2697	54	the	the	DT
cord-015021-pol2qm74	2697	55	involvement	involvement	NN
cord-015021-pol2qm74	2697	56	of	of	IN
cord-015021-pol2qm74	2697	57	phosphatidylcholinespecific	phosphatidylcholinespecific	NNP
cord-015021-pol2qm74	2697	58	phospholipase	phospholipase	NNP
cord-015021-pol2qm74	2697	59	C	C	NNP
cord-015021-pol2qm74	2697	60	(	(	-LRB-
cord-015021-pol2qm74	2697	61	PC	PC	NNP
cord-015021-pol2qm74	2697	62	-	-	HYPH
cord-015021-pol2qm74	2697	63	PLC	PLC	NNP
cord-015021-pol2qm74	2697	64	)	)	-RRB-
cord-015021-pol2qm74	2697	65	and	and	CC
cord-015021-pol2qm74	2697	66	proteinkinase	proteinkinase	NNP
cord-015021-pol2qm74	2697	67	C	C	NNP
cord-015021-pol2qm74	2697	68	(	(	-LRB-
cord-015021-pol2qm74	2697	69	PKC	PKC	NNP
cord-015021-pol2qm74	2697	70	)	)	-RRB-
cord-015021-pol2qm74	2697	71	.	.	.
cord-015021-pol2qm74	2698	1	Materials	material	NNS
cord-015021-pol2qm74	2698	2	and	and	CC
cord-015021-pol2qm74	2698	3	Methods	method	NNS
cord-015021-pol2qm74	2698	4	:	:	:
cord-015021-pol2qm74	2698	5	NO	no	JJ
cord-015021-pol2qm74	2698	6	-	-	HYPH
cord-015021-pol2qm74	2698	7	production	production	NN
cord-015021-pol2qm74	2698	8	was	be	VBD
cord-015021-pol2qm74	2698	9	induced	induce	VBN
cord-015021-pol2qm74	2698	10	in	in	IN
cord-015021-pol2qm74	2698	11	the	the	DT
cord-015021-pol2qm74	2698	12	murine	murine	JJ
cord-015021-pol2qm74	2698	13	macrophage	macrophage	NN
cord-015021-pol2qm74	2698	14	cell	cell	NN
cord-015021-pol2qm74	2698	15	line	line	NN
cord-015021-pol2qm74	2698	16	J774	J774	NNS
cord-015021-pol2qm74	2698	17	with	with	IN
cord-015021-pol2qm74	2698	18	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	2698	19	(	(	-LRB-
cord-015021-pol2qm74	2698	20	LPS	LPS	NNP
cord-015021-pol2qm74	2698	21	)	)	-RRB-
cord-015021-pol2qm74	2698	22	[	[	-LRB-
cord-015021-pol2qm74	2698	23	llJg	lljg	NN
cord-015021-pol2qm74	2698	24	/	/	SYM
cord-015021-pol2qm74	2698	25	ml	ml	NN
cord-015021-pol2qm74	2698	26	]	]	-RRB-
cord-015021-pol2qm74	2698	27	and	and	CC
cord-015021-pol2qm74	2698	28	interferon	interferon	NN
cord-015021-pol2qm74	2698	29	;	;	:
cord-015021-pol2qm74	2698	30	f	f	LS
cord-015021-pol2qm74	2698	31	(	(	-LRB-
cord-015021-pol2qm74	2698	32	IFNy	IFNy	NNP
cord-015021-pol2qm74	2698	33	)	)	-RRB-
cord-015021-pol2qm74	2699	1	[	[	-LRB-
cord-015021-pol2qm74	2699	2	200U	200u	CD
cord-015021-pol2qm74	2699	3	/	/	SYM
cord-015021-pol2qm74	2699	4	ml	ml	NN
cord-015021-pol2qm74	2699	5	]	]	-RRB-
cord-015021-pol2qm74	2699	6	.	.	.
cord-015021-pol2qm74	2700	1	After	after	IN
cord-015021-pol2qm74	2700	2	18	18	CD
cord-015021-pol2qm74	2700	3	hours	hour	NNS
cord-015021-pol2qm74	2700	4	of	of	IN
cord-015021-pol2qm74	2700	5	incubation	incubation	NN
cord-015021-pol2qm74	2700	6	NO	no	NN
cord-015021-pol2qm74	2700	7	-	-	HYPH
cord-015021-pol2qm74	2700	8	release	release	NN
cord-015021-pol2qm74	2700	9	was	be	VBD
cord-015021-pol2qm74	2700	10	determined	determine	VBN
cord-015021-pol2qm74	2700	11	as	as	IN
cord-015021-pol2qm74	2700	12	nitrite	nitrite	NN
cord-015021-pol2qm74	2700	13	(	(	-LRB-
cord-015021-pol2qm74	2700	14	NO2	NO2	NNP
cord-015021-pol2qm74	2700	15	)	)	-RRB-
cord-015021-pol2qm74	2700	16	by	by	IN
cord-015021-pol2qm74	2700	17	using	use	VBG
cord-015021-pol2qm74	2700	18	a	a	DT
cord-015021-pol2qm74	2700	19	colorimetric	colorimetric	JJ
cord-015021-pol2qm74	2700	20	assay	assay	NN
cord-015021-pol2qm74	2700	21	based	base	VBN
cord-015021-pol2qm74	2700	22	on	on	IN
cord-015021-pol2qm74	2700	23	the	the	DT
cord-015021-pol2qm74	2700	24	Griess	Griess	NNP
cord-015021-pol2qm74	2700	25	-	-	HYPH
cord-015021-pol2qm74	2700	26	reaetion	reaetion	NN
cord-015021-pol2qm74	2700	27	.	.	.
cord-015021-pol2qm74	2701	1	Results	result	NNS
cord-015021-pol2qm74	2701	2	:	:	:
cord-015021-pol2qm74	2701	3	Preincubation	preincubation	NN
cord-015021-pol2qm74	2701	4	of	of	IN
cord-015021-pol2qm74	2701	5	cells	cell	NNS
cord-015021-pol2qm74	2701	6	with	with	IN
cord-015021-pol2qm74	2701	7	the	the	DT
cord-015021-pol2qm74	2701	8	PKC	PKC	NNP
cord-015021-pol2qm74	2701	9	-	-	HYPH
cord-015021-pol2qm74	2701	10	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	2701	11	staurosporine	staurosporine	JJ
cord-015021-pol2qm74	2701	12	(	(	-LRB-
cord-015021-pol2qm74	2701	13	STP	STP	NNP
cord-015021-pol2qm74	2701	14	)	)	-RRB-
cord-015021-pol2qm74	2701	15	,	,	,
cord-015021-pol2qm74	2701	16	chelerythrine	chelerythrine	NN
cord-015021-pol2qm74	2701	17	,	,	,
cord-015021-pol2qm74	2701	18	bisindolylmaleimide	bisindolylmaleimide	JJ
cord-015021-pol2qm74	2701	19	(	(	-LRB-
cord-015021-pol2qm74	2701	20	BIM	BIM	NNP
cord-015021-pol2qm74	2701	21	)	)	-RRB-
cord-015021-pol2qm74	2701	22	and	and	CC
cord-015021-pol2qm74	2701	23	D609	D609	NNP
cord-015021-pol2qm74	2701	24	,	,	,
cord-015021-pol2qm74	2701	25	that	that	WDT
cord-015021-pol2qm74	2701	26	recently	recently	RB
cord-015021-pol2qm74	2701	27	has	have	VBZ
cord-015021-pol2qm74	2701	28	been	be	VBN
cord-015021-pol2qm74	2701	29	identified	identify	VBN
cord-015021-pol2qm74	2701	30	as	as	IN
cord-015021-pol2qm74	2701	31	a	a	DT
cord-015021-pol2qm74	2701	32	selective	selective	JJ
cord-015021-pol2qm74	2701	33	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2701	34	of	of	IN
cord-015021-pol2qm74	2701	35	PC	PC	NNP
cord-015021-pol2qm74	2701	36	-	-	HYPH
cord-015021-pol2qm74	2701	37	PLC	PLC	NNP
cord-015021-pol2qm74	2701	38	,	,	,
cord-015021-pol2qm74	2701	39	diminished	diminish	VBD
cord-015021-pol2qm74	2701	40	significantly	significantly	RB
cord-015021-pol2qm74	2701	41	LPSand	LPSand	NNP
cord-015021-pol2qm74	2701	42	]	]	-RRB-
cord-015021-pol2qm74	2701	43	FNT	fnt	NN
cord-015021-pol2qm74	2701	44	-	-	HYPH
cord-015021-pol2qm74	2701	45	induced	induce	VBN
cord-015021-pol2qm74	2701	46	NO2-production	no2-production	NN
cord-015021-pol2qm74	2701	47	(	(	-LRB-
cord-015021-pol2qm74	2701	48	p	p	NN
cord-015021-pol2qm74	2701	49	<	<	XX
cord-015021-pol2qm74	2701	50	O,001	O,001	NNP
cord-015021-pol2qm74	2701	51	)	)	-RRB-
cord-015021-pol2qm74	2701	52	.	.	.
cord-015021-pol2qm74	2702	1	Although	although	IN
cord-015021-pol2qm74	2702	2	we	-PRON-	PRP
cord-015021-pol2qm74	2702	3	observed	observe	VBD
cord-015021-pol2qm74	2702	4	no	no	DT
cord-015021-pol2qm74	2702	5	toxic	toxic	JJ
cord-015021-pol2qm74	2702	6	effect	effect	NN
cord-015021-pol2qm74	2702	7	on	on	IN
cord-015021-pol2qm74	2702	8	cell	cell	NN
cord-015021-pol2qm74	2702	9	viability	viability	NN
cord-015021-pol2qm74	2702	10	,	,	,
cord-015021-pol2qm74	2702	11	NO2-production	no2-production	NN
cord-015021-pol2qm74	2702	12	was	be	VBD
cord-015021-pol2qm74	2702	13	related	relate	VBN
cord-015021-pol2qm74	2702	14	to	to	IN
cord-015021-pol2qm74	2702	15	protein	protein	NN
cord-015021-pol2qm74	2702	16	concentrations	concentration	NNS
cord-015021-pol2qm74	2702	17	to	to	TO
cord-015021-pol2qm74	2702	18	exclude	exclude	VB
cord-015021-pol2qm74	2702	19	any	any	DT
cord-015021-pol2qm74	2702	20	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	2702	21	effect	effect	NN
cord-015021-pol2qm74	2702	22	on	on	IN
cord-015021-pol2qm74	2702	23	celt	celt	JJ
cord-015021-pol2qm74	2702	24	growth	growth	NN
cord-015021-pol2qm74	2702	25	.	.	.
cord-015021-pol2qm74	2703	1	Celts	Celts	NNPS
cord-015021-pol2qm74	2703	2	preincubated	preincubate	VBD
cord-015021-pol2qm74	2703	3	with	with	IN
cord-015021-pol2qm74	2703	4	STP	STP	NNP
cord-015021-pol2qm74	2703	5	[	[	-LRB-
cord-015021-pol2qm74	2703	6	lO0nM	lO0nM	NNP
cord-015021-pol2qm74	2703	7	]	]	-RRB-
cord-015021-pol2qm74	2703	8	released	release	VBN
cord-015021-pol2qm74	2703	9	20	20	CD
cord-015021-pol2qm74	2703	10	%	%	NN
cord-015021-pol2qm74	2703	11	less	less	JJR
cord-015021-pol2qm74	2703	12	NO	no	DT
cord-015021-pol2qm74	2703	13	2	2	CD
cord-015021-pol2qm74	2703	14	in	in	IN
cord-015021-pol2qm74	2703	15	response	response	NN
cord-015021-pol2qm74	2703	16	to	to	IN
cord-015021-pol2qm74	2703	17	LPS	LPS	NNP
cord-015021-pol2qm74	2703	18	and	and	CC
cord-015021-pol2qm74	2703	19	IFN	IFN	NNP
cord-015021-pol2qm74	2703	20	,	,	,
cord-015021-pol2qm74	2703	21	[	[	-LRB-
cord-015021-pol2qm74	2703	22	compared	compare	VBN
cord-015021-pol2qm74	2703	23	to	to	TO
cord-015021-pol2qm74	2703	24	control	control	NN
cord-015021-pol2qm74	2703	25	cells	cell	NNS
cord-015021-pol2qm74	2703	26	cultured	culture	VBN
cord-015021-pol2qm74	2703	27	without	without	IN
cord-015021-pol2qm74	2703	28	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2703	29	.	.	.
cord-015021-pol2qm74	2704	1	Chelerythrine	Chelerythrine	NNP
cord-015021-pol2qm74	2704	2	[	[	-LRB-
cord-015021-pol2qm74	2704	3	30}JM	30}jm	CD
cord-015021-pol2qm74	2704	4	]	]	-RRB-
cord-015021-pol2qm74	2704	5	and	and	CC
cord-015021-pol2qm74	2704	6	BIM	BIM	NNP
cord-015021-pol2qm74	2704	7	[	[	-LRB-
cord-015021-pol2qm74	2704	8	IOIJM	IOIJM	NNP
cord-015021-pol2qm74	2704	9	]	]	-RRB-
cord-015021-pol2qm74	2704	10	reduced	reduce	VBD
cord-015021-pol2qm74	2704	11	the	the	DT
cord-015021-pol2qm74	2704	12	NO2-formation	no2-formation	NN
cord-015021-pol2qm74	2704	13	by	by	IN
cord-015021-pol2qm74	2704	14	50	50	CD
cord-015021-pol2qm74	2704	15	%	%	NN
cord-015021-pol2qm74	2704	16	and	and	CC
cord-015021-pol2qm74	2704	17	85	85	CD
cord-015021-pol2qm74	2704	18	%	%	NN
cord-015021-pol2qm74	2704	19	,	,	,
cord-015021-pol2qm74	2704	20	respectively	respectively	RB
cord-015021-pol2qm74	2704	21	.	.	.
cord-015021-pol2qm74	2705	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	2705	2	,	,	,
cord-015021-pol2qm74	2705	3	the	the	DT
cord-015021-pol2qm74	2705	4	most	most	RBS
cord-015021-pol2qm74	2705	5	potent	potent	JJ
cord-015021-pol2qm74	2705	6	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2705	7	of	of	IN
cord-015021-pol2qm74	2705	8	NO	no	JJ
cord-015021-pol2qm74	2705	9	-	-	HYPH
cord-015021-pol2qm74	2705	10	production	production	NN
cord-015021-pol2qm74	2705	11	turned	turn	VBD
cord-015021-pol2qm74	2705	12	out	out	RP
cord-015021-pol2qm74	2705	13	to	to	TO
cord-015021-pol2qm74	2705	14	be	be	VB
cord-015021-pol2qm74	2705	15	the	the	DT
cord-015021-pol2qm74	2705	16	xanthate	xanthate	NNP
cord-015021-pol2qm74	2705	17	D609	D609	NNP
cord-015021-pol2qm74	2705	18	Cells	Cells	NNP
cord-015021-pol2qm74	2705	19	pretreated	pretreate	VBD
cord-015021-pol2qm74	2705	20	with	with	IN
cord-015021-pol2qm74	2705	21	D609	D609	NNPS
cord-015021-pol2qm74	2705	22	[	[	-LRB-
cord-015021-pol2qm74	2705	23	301~g	301~g	CD
cord-015021-pol2qm74	2705	24	/	/	SYM
cord-015021-pol2qm74	2705	25	mt	mt	NNP
cord-015021-pol2qm74	2705	26	]	]	-RRB-
cord-015021-pol2qm74	2705	27	released	release	VBD
cord-015021-pol2qm74	2705	28	96	96	CD
cord-015021-pol2qm74	2705	29	%	%	NN
cord-015021-pol2qm74	2705	30	less	less	JJR
cord-015021-pol2qm74	2705	31	NO	no	DT
cord-015021-pol2qm74	2705	32	2	2	CD
cord-015021-pol2qm74	2705	33	than	than	IN
cord-015021-pol2qm74	2705	34	stimulated	stimulated	JJ
cord-015021-pol2qm74	2705	35	controls	control	NNS
cord-015021-pol2qm74	2706	1	The	the	DT
cord-015021-pol2qm74	2706	2	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	2706	3	effect	effect	NN
cord-015021-pol2qm74	2706	4	on	on	IN
cord-015021-pol2qm74	2706	5	NO	no	DT
cord-015021-pol2qm74	2706	6	2production	2production	CD
cord-015021-pol2qm74	2706	7	decreased	decrease	VBD
cord-015021-pol2qm74	2706	8	the	the	DT
cord-015021-pol2qm74	2706	9	later	later	RB
cord-015021-pol2qm74	2706	10	the	the	DT
cord-015021-pol2qm74	2706	11	inhibitore	inhibitore	NN
cord-015021-pol2qm74	2706	12	were	be	VBD
cord-015021-pol2qm74	2706	13	added	add	VBN
cord-015021-pol2qm74	2706	14	after	after	IN
cord-015021-pol2qm74	2706	15	stimulation	stimulation	NN
cord-015021-pol2qm74	2706	16	;	;	:
cord-015021-pol2qm74	2706	17	e.g.	e.g.	RB
cord-015021-pol2qm74	2706	18	BIM	BIM	NNP
cord-015021-pol2qm74	2706	19	added	add	VBD
cord-015021-pol2qm74	2706	20	6	6	CD
cord-015021-pol2qm74	2706	21	and	and	CC
cord-015021-pol2qm74	2706	22	12	12	CD
cord-015021-pol2qm74	2706	23	hours	hour	NNS
cord-015021-pol2qm74	2706	24	after	after	IN
cord-015021-pol2qm74	2706	25	stimulation	stimulation	NN
cord-015021-pol2qm74	2706	26	reduced	reduce	VBD
cord-015021-pol2qm74	2706	27	NO2-production	no2-production	NN
cord-015021-pol2qm74	2706	28	only	only	RB
cord-015021-pol2qm74	2706	29	by	by	IN
cord-015021-pol2qm74	2706	30	50	50	CD
cord-015021-pol2qm74	2706	31	%	%	NN
cord-015021-pol2qm74	2706	32	and	and	CC
cord-015021-pol2qm74	2706	33	12	12	CD
cord-015021-pol2qm74	2706	34	%	%	NN
cord-015021-pol2qm74	2706	35	,	,	,
cord-015021-pol2qm74	2706	36	respectively	respectively	RB
cord-015021-pol2qm74	2706	37	.	.	.
cord-015021-pol2qm74	2707	1	Accordingly	accordingly	RB
cord-015021-pol2qm74	2707	2	,	,	,
cord-015021-pol2qm74	2707	3	iNQS	inqs	JJ
cord-015021-pol2qm74	2707	4	activity	activity	NN
cord-015021-pol2qm74	2707	5	present	present	NN
cord-015021-pol2qm74	2707	6	in	in	IN
cord-015021-pol2qm74	2707	7	stimulated	stimulated	JJ
cord-015021-pol2qm74	2707	8	cell	cell	NN
cord-015021-pol2qm74	2707	9	lysates	lysate	NNS
cord-015021-pol2qm74	2707	10	supplemented	supplement	VBN
cord-015021-pol2qm74	2707	11	with	with	IN
cord-015021-pol2qm74	2707	12	L	l	NN
cord-015021-pol2qm74	2707	13	-	-	HYPH
cord-015021-pol2qm74	2707	14	arginine	arginine	NN
cord-015021-pol2qm74	2707	15	and	and	CC
cord-015021-pol2qm74	2707	16	co	co	NNS
cord-015021-pol2qm74	2707	17	-	-	NNS
cord-015021-pol2qm74	2707	18	factors	factor	NNS
cord-015021-pol2qm74	2707	19	was	be	VBD
cord-015021-pol2qm74	2707	20	not	not	RB
cord-015021-pol2qm74	2707	21	suppressed	suppress	VBN
cord-015021-pol2qm74	2707	22	by	by	IN
cord-015021-pol2qm74	2707	23	the	the	DT
cord-015021-pol2qm74	2707	24	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	2707	25	tested	test	VBN
cord-015021-pol2qm74	2707	26	.	.	.
cord-015021-pol2qm74	2708	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	2708	2	:	:	:
cord-015021-pol2qm74	2709	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2709	2	findings	finding	NNS
cord-015021-pol2qm74	2709	3	suggest	suggest	VBP
cord-015021-pol2qm74	2709	4	,	,	,
cord-015021-pol2qm74	2709	5	that	that	IN
cord-015021-pol2qm74	2709	6	the	the	DT
cord-015021-pol2qm74	2709	7	induction	induction	NN
cord-015021-pol2qm74	2709	8	of	of	IN
cord-015021-pol2qm74	2709	9	iNOS	inos	NN
cord-015021-pol2qm74	2709	10	but	but	CC
cord-015021-pol2qm74	2709	11	not	not	RB
cord-015021-pol2qm74	2709	12	its	-PRON-	PRP$
cord-015021-pol2qm74	2709	13	activity	activity	NN
cord-015021-pol2qm74	2709	14	is	be	VBZ
cord-015021-pol2qm74	2709	15	a	a	DT
cord-015021-pol2qm74	2709	16	PKC	PKC	NNP
cord-015021-pol2qm74	2709	17	and	and	CC
cord-015021-pol2qm74	2709	18	particularly	particularly	RB
cord-015021-pol2qm74	2709	19	PC	PC	NNP
cord-015021-pol2qm74	2709	20	-	-	HYPH
cord-015021-pol2qm74	2709	21	PLC	plc	NN
cord-015021-pol2qm74	2709	22	dependent	dependent	JJ
cord-015021-pol2qm74	2709	23	process	process	NN
cord-015021-pol2qm74	2709	24	.	.	.
cord-015021-pol2qm74	2710	1	Dr.	Dr.	NNP
cord-015021-pol2qm74	2710	2	K	K	NNP
cord-015021-pol2qm74	2710	3	Tschaikowsky	Tschaikowsky	NNP
cord-015021-pol2qm74	2710	4	,	,	,
cord-015021-pol2qm74	2710	5	Institut	Institut	NNP
cord-015021-pol2qm74	2710	6	for	for	IN
cord-015021-pol2qm74	2710	7	Anaesthesiologie	Anaesthesiologie	NNP
cord-015021-pol2qm74	2710	8	,	,	,
cord-015021-pol2qm74	2710	9	Universital	Universital	NNP
cord-015021-pol2qm74	2710	10	Erlangen	Erlangen	NNP
cord-015021-pol2qm74	2710	11	--	--	:
cord-015021-pol2qm74	2710	12	NQrnberg	NQrnberg	NNP
cord-015021-pol2qm74	2710	13	,	,	,
cord-015021-pol2qm74	2710	14	Krankenhausstr	Krankenhausstr	NNP
cord-015021-pol2qm74	2710	15	12	12	CD
cord-015021-pol2qm74	2710	16	,	,	,
cord-015021-pol2qm74	2710	17	91054	91054	CD
cord-015021-pol2qm74	2710	18	Erlangen	Erlangen	NNP
cord-015021-pol2qm74	2710	19	Interleukin-1	Interleukin-1	NNP
cord-015021-pol2qm74	2710	20	(	(	-LRB-
cord-015021-pol2qm74	2710	21	IL-1	IL-1	NNP
cord-015021-pol2qm74	2710	22	)	)	-RRB-
cord-015021-pol2qm74	2710	23	affects	affect	VBZ
cord-015021-pol2qm74	2710	24	nearly	nearly	RB
cord-015021-pol2qm74	2710	25	every	every	DT
cord-015021-pol2qm74	2710	26	cell	cell	NN
cord-015021-pol2qm74	2710	27	type	type	NN
cord-015021-pol2qm74	2710	28	by	by	IN
cord-015021-pol2qm74	2710	29	increasing	increase	VBG
cord-015021-pol2qm74	2710	30	the	the	DT
cord-015021-pol2qm74	2710	31	expression	expression	NN
cord-015021-pol2qm74	2710	32	of	of	IN
cord-015021-pol2qm74	2710	33	a	a	DT
cord-015021-pol2qm74	2710	34	variety	variety	NN
cord-015021-pol2qm74	2710	35	of	of	IN
cord-015021-pol2qm74	2710	36	genes	gene	NNS
cord-015021-pol2qm74	2710	37	associated	associate	VBN
cord-015021-pol2qm74	2710	38	with	with	IN
cord-015021-pol2qm74	2710	39	the	the	DT
cord-015021-pol2qm74	2710	40	promotion	promotion	NN
cord-015021-pol2qm74	2710	41	of	of	IN
cord-015021-pol2qm74	2710	42	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2710	43	processes	process	NNS
cord-015021-pol2qm74	2710	44	.	.	.
cord-015021-pol2qm74	2711	1	These	these	DT
cord-015021-pol2qm74	2711	2	include	include	VBP
cord-015021-pol2qm74	2711	3	upregulation	upregulation	NN
cord-015021-pol2qm74	2711	4	of	of	IN
cord-015021-pol2qm74	2711	5	cyclooxygenase	cyclooxygenase	NN
cord-015021-pol2qm74	2711	6	and	and	CC
cord-015021-pol2qm74	2711	7	nitric	nitric	JJ
cord-015021-pol2qm74	2711	8	acid	acid	NN
cord-015021-pol2qm74	2711	9	synthases	synthase	NNS
cord-015021-pol2qm74	2711	10	.	.	.
cord-015021-pol2qm74	2712	1	The	the	DT
cord-015021-pol2qm74	2712	2	IL-1RI	IL-1RI	NNP
cord-015021-pol2qm74	2712	3	transmits	transmit	VBZ
cord-015021-pol2qm74	2712	4	a	a	DT
cord-015021-pol2qm74	2712	5	signal(s	signal(s	NNP
cord-015021-pol2qm74	2712	6	)	)	-RRB-
cord-015021-pol2qm74	2712	7	through	through	IN
cord-015021-pol2qm74	2712	8	the	the	DT
cord-015021-pol2qm74	2712	9	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	2712	10	domain	domain	NN
cord-015021-pol2qm74	2712	11	which	which	WDT
cord-015021-pol2qm74	2712	12	is	be	VBZ
cord-015021-pol2qm74	2712	13	structurally	structurally	RB
cord-015021-pol2qm74	2712	14	related	related	JJ
cord-015021-pol2qm74	2712	15	to	to	IN
cord-015021-pol2qm74	2712	16	the	the	DT
cord-015021-pol2qm74	2712	17	fruit	fruit	NN
cord-015021-pol2qm74	2712	18	fly	fly	VB
cord-015021-pol2qm74	2712	19	Toll	toll	NN
cord-015021-pol2qm74	2712	20	protein	protein	NN
cord-015021-pol2qm74	2712	21	.	.	.
cord-015021-pol2qm74	2713	1	We	-PRON-	PRP
cord-015021-pol2qm74	2713	2	have	have	VBP
cord-015021-pol2qm74	2713	3	recently	recently	RB
cord-015021-pol2qm74	2713	4	cloned	clone	VBN
cord-015021-pol2qm74	2713	5	the	the	DT
cord-015021-pol2qm74	2713	6	promotor	promotor	NN
cord-015021-pol2qm74	2713	7	most	most	RBS
cord-015021-pol2qm74	2713	8	proximal	proximal	JJ
cord-015021-pol2qm74	2713	9	to	to	IN
cord-015021-pol2qm74	2713	10	the	the	DT
cord-015021-pol2qm74	2713	11	5	5	CD
cord-015021-pol2qm74	2713	12	'	'	POS
cord-015021-pol2qm74	2713	13	UTR	UTR	NNP
cord-015021-pol2qm74	2713	14	of	of	IN
cord-015021-pol2qm74	2713	15	the	the	DT
cord-015021-pol2qm74	2713	16	human	human	JJ
cord-015021-pol2qm74	2713	17	IL-1RI	IL-1RI	NNP
cord-015021-pol2qm74	2713	18	gene	gene	NN
cord-015021-pol2qm74	2713	19	.	.	.
cord-015021-pol2qm74	2714	1	The	the	DT
cord-015021-pol2qm74	2714	2	genomic	genomic	JJ
cord-015021-pol2qm74	2714	3	sequences	sequence	NNS
cord-015021-pol2qm74	2714	4	reveal	reveal	VBP
cord-015021-pol2qm74	2714	5	a	a	DT
cord-015021-pol2qm74	2714	6	lack	lack	NN
cord-015021-pol2qm74	2714	7	of	of	IN
cord-015021-pol2qm74	2714	8	TATA	TATA	NNP
cord-015021-pol2qm74	2714	9	and	and	CC
cord-015021-pol2qm74	2714	10	CAAT	CAAT	NNP
cord-015021-pol2qm74	2714	11	boxes	box	NNS
cord-015021-pol2qm74	2714	12	but	but	CC
cord-015021-pol2qm74	2714	13	rather	rather	RB
cord-015021-pol2qm74	2714	14	a	a	DT
cord-015021-pol2qm74	2714	15	considerable	considerable	JJ
cord-015021-pol2qm74	2714	16	(	(	-LRB-
cord-015021-pol2qm74	2714	17	75	75	CD
cord-015021-pol2qm74	2714	18	%	%	NN
cord-015021-pol2qm74	2714	19	)	)	-RRB-
cord-015021-pol2qm74	2715	1	GC	GC	NNP
cord-015021-pol2qm74	2715	2	rich	rich	JJ
cord-015021-pol2qm74	2715	3	region	region	NN
cord-015021-pol2qm74	2715	4	.	.	.
cord-015021-pol2qm74	2716	1	The	the	DT
cord-015021-pol2qm74	2716	2	translation	translation	NN
cord-015021-pol2qm74	2716	3	of	of	IN
cord-015021-pol2qm74	2716	4	the	the	DT
cord-015021-pol2qm74	2716	5	type	type	NN
cord-015021-pol2qm74	2717	1	I	-PRON-	PRP
cord-015021-pol2qm74	2717	2	IL-1R	il-1r	VBP
cord-015021-pol2qm74	2717	3	appears	appear	VBZ
cord-015021-pol2qm74	2717	4	under	under	IN
cord-015021-pol2qm74	2717	5	a	a	DT
cord-015021-pol2qm74	2717	6	significant	significant	JJ
cord-015021-pol2qm74	2717	7	suppression	suppression	NN
cord-015021-pol2qm74	2717	8	and	and	CC
cord-015021-pol2qm74	2717	9	may	may	MD
cord-015021-pol2qm74	2717	10	limit	limit	VB
cord-015021-pol2qm74	2717	11	the	the	DT
cord-015021-pol2qm74	2717	12	biological	biological	JJ
cord-015021-pol2qm74	2717	13	activities	activity	NNS
cord-015021-pol2qm74	2717	14	of	of	IN
cord-015021-pol2qm74	2717	15	IL-1	IL-1	NNP
cord-015021-pol2qm74	2717	16	by	by	IN
cord-015021-pol2qm74	2717	17	low	low	JJ
cord-015021-pol2qm74	2717	18	level	level	NN
cord-015021-pol2qm74	2717	19	of	of	IN
cord-015021-pol2qm74	2717	20	expression	expression	NN
cord-015021-pol2qm74	2717	21	.	.	.
cord-015021-pol2qm74	2718	1	On	on	IN
cord-015021-pol2qm74	2718	2	the	the	DT
cord-015021-pol2qm74	2718	3	other	other	JJ
cord-015021-pol2qm74	2718	4	hand	hand	NN
cord-015021-pol2qm74	2718	5	,	,	,
cord-015021-pol2qm74	2718	6	the	the	DT
cord-015021-pol2qm74	2718	7	type	type	NN
cord-015021-pol2qm74	2718	8	II	II	NNP
cord-015021-pol2qm74	2718	9	IL-1R	IL-1R	NNP
cord-015021-pol2qm74	2718	10	,	,	,
cord-015021-pol2qm74	2718	11	lacking	lack	VBG
cord-015021-pol2qm74	2718	12	a	a	DT
cord-015021-pol2qm74	2718	13	significant	significant	JJ
cord-015021-pol2qm74	2718	14	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	2718	15	domain	domain	NN
cord-015021-pol2qm74	2718	16	,	,	,
cord-015021-pol2qm74	2718	17	does	do	VBZ
cord-015021-pol2qm74	2718	18	not	not	RB
cord-015021-pol2qm74	2718	19	transmit	transmit	VB
cord-015021-pol2qm74	2718	20	a	a	DT
cord-015021-pol2qm74	2718	21	signal	signal	NN
cord-015021-pol2qm74	2718	22	and	and	CC
cord-015021-pol2qm74	2718	23	acts	act	VBZ
cord-015021-pol2qm74	2718	24	as	as	IN
cord-015021-pol2qm74	2718	25	a	a	DT
cord-015021-pol2qm74	2718	26	decoy	decoy	NN
cord-015021-pol2qm74	2718	27	receptor	receptor	NN
cord-015021-pol2qm74	2718	28	preventing	prevent	VBG
cord-015021-pol2qm74	2718	29	the	the	DT
cord-015021-pol2qm74	2718	30	binding	binding	NN
cord-015021-pol2qm74	2718	31	to	to	IN
cord-015021-pol2qm74	2718	32	the	the	DT
cord-015021-pol2qm74	2718	33	type	type	NN
cord-015021-pol2qm74	2718	34	I	-PRON-	PRP
cord-015021-pol2qm74	2718	35	receptor	receptor	NN
cord-015021-pol2qm74	2718	36	.	.	.
cord-015021-pol2qm74	2719	1	There	there	EX
cord-015021-pol2qm74	2719	2	are	be	VBP
cord-015021-pol2qm74	2719	3	several	several	JJ
cord-015021-pol2qm74	2719	4	approaches	approach	NNS
cord-015021-pol2qm74	2719	5	to	to	IN
cord-015021-pol2qm74	2719	6	reducing	reduce	VBG
cord-015021-pol2qm74	2719	7	IL-1	IL-1	NNP
cord-015021-pol2qm74	2719	8	activity	activity	NN
cord-015021-pol2qm74	2719	9	;	;	:
cord-015021-pol2qm74	2719	10	inhibition	inhibition	NN
cord-015021-pol2qm74	2719	11	of	of	IN
cord-015021-pol2qm74	2719	12	IL-1	IL-1	NNP
cord-015021-pol2qm74	2719	13	converting	convert	VBG
cord-015021-pol2qm74	2719	14	enzyme	enzyme	NN
cord-015021-pol2qm74	2719	15	which	which	WDT
cord-015021-pol2qm74	2719	16	cleaves	cleave	VBZ
cord-015021-pol2qm74	2719	17	pro	pro	JJ
cord-015021-pol2qm74	2719	18	-	-	JJ
cord-015021-pol2qm74	2719	19	IL	IL	NNP
cord-015021-pol2qm74	2719	20	-	-	HYPH
cord-015021-pol2qm74	2719	21	l[3	l[3	JJ
cord-015021-pol2qm74	2719	22	,	,	,
cord-015021-pol2qm74	2719	23	anti	anti	JJ
cord-015021-pol2qm74	2719	24	-	-	NNP
cord-015021-pol2qm74	2719	25	IL-1RI	il-1ri	JJ
cord-015021-pol2qm74	2719	26	,	,	,
cord-015021-pol2qm74	2719	27	the	the	DT
cord-015021-pol2qm74	2719	28	IL	IL	NNP
cord-015021-pol2qm74	2719	29	-	-	HYPH
cord-015021-pol2qm74	2719	30	I	I	NNP
cord-015021-pol2qm74	2719	31	receptor	receptor	NN
cord-015021-pol2qm74	2719	32	antagonist	antagonist	NN
cord-015021-pol2qm74	2719	33	(	(	-LRB-
cord-015021-pol2qm74	2719	34	IL-1Ra	il-1ra	NN
cord-015021-pol2qm74	2719	35	)	)	-RRB-
cord-015021-pol2qm74	2719	36	and	and	CC
cord-015021-pol2qm74	2719	37	soluble	soluble	JJ
cord-015021-pol2qm74	2719	38	(	(	-LRB-
cord-015021-pol2qm74	2719	39	extracellular	extracellular	JJ
cord-015021-pol2qm74	2719	40	)	)	-RRB-
cord-015021-pol2qm74	2719	41	IL-1RI	il-1ri	NN
cord-015021-pol2qm74	2719	42	and	and	CC
cord-015021-pol2qm74	2719	43	IL-1RII	IL-1RII	NNP
cord-015021-pol2qm74	2719	44	.	.	.
cord-015021-pol2qm74	2720	1	IL-1Ra	il-1ra	NN
cord-015021-pol2qm74	2720	2	is	be	VBZ
cord-015021-pol2qm74	2720	3	structurally	structurally	RB
cord-015021-pol2qm74	2720	4	related	related	JJ
cord-015021-pol2qm74	2720	5	to	to	IN
cord-015021-pol2qm74	2720	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	2720	7	and	and	CC
cord-015021-pol2qm74	2720	8	binds	bind	VBZ
cord-015021-pol2qm74	2720	9	at	at	IN
cord-015021-pol2qm74	2720	10	4	4	CD
cord-015021-pol2qm74	2720	11	°	°	NN
cord-015021-pol2qm74	2720	12	C	c	NN
cord-015021-pol2qm74	2720	13	to	to	IN
cord-015021-pol2qm74	2720	14	the	the	DT
cord-015021-pol2qm74	2720	15	IL-1RI	IL-1RI	NNP
cord-015021-pol2qm74	2720	16	with	with	IN
cord-015021-pol2qm74	2720	17	near	near	IN
cord-015021-pol2qm74	2720	18	equal	equal	JJ
cord-015021-pol2qm74	2720	19	affinity	affinity	NN
cord-015021-pol2qm74	2720	20	as	as	IN
cord-015021-pol2qm74	2720	21	that	that	DT
cord-015021-pol2qm74	2720	22	of	of	IN
cord-015021-pol2qm74	2720	23	bona	bona	FW
cord-015021-pol2qm74	2720	24	fide	fide	FW
cord-015021-pol2qm74	2720	25	IL	il	NN
cord-015021-pol2qm74	2720	26	-	-	HYPH
cord-015021-pol2qm74	2720	27	I	I	NNP
cord-015021-pol2qm74	2720	28	;	;	:
cord-015021-pol2qm74	2720	29	however	however	RB
cord-015021-pol2qm74	2720	30	,	,	,
cord-015021-pol2qm74	2720	31	IL-1Ra	IL-1Ra	NNP
cord-015021-pol2qm74	2720	32	does	do	VBZ
cord-015021-pol2qm74	2720	33	not	not	RB
cord-015021-pol2qm74	2720	34	transduce	transduce	VB
cord-015021-pol2qm74	2720	35	a	a	DT
cord-015021-pol2qm74	2720	36	signal	signal	NN
cord-015021-pol2qm74	2720	37	.	.	.
cord-015021-pol2qm74	2721	1	IL-1Ra	il-1ra	NN
cord-015021-pol2qm74	2721	2	has	have	VBZ
cord-015021-pol2qm74	2721	3	been	be	VBN
cord-015021-pol2qm74	2721	4	given	give	VBN
cord-015021-pol2qm74	2721	5	to	to	IN
cord-015021-pol2qm74	2721	6	humans	human	NNS
cord-015021-pol2qm74	2721	7	in	in	IN
cord-015021-pol2qm74	2721	8	pharmacologic	pharmacologic	JJ
cord-015021-pol2qm74	2721	9	levels	level	NNS
cord-015021-pol2qm74	2721	10	(	(	-LRB-
cord-015021-pol2qm74	2721	11	mean	mean	VB
cord-015021-pol2qm74	2721	12	plasma	plasma	NN
cord-015021-pol2qm74	2721	13	levels	level	NNS
cord-015021-pol2qm74	2721	14	of	of	IN
cord-015021-pol2qm74	2721	15	30gg	30gg	NN
cord-015021-pol2qm74	2721	16	/	/	SYM
cord-015021-pol2qm74	2721	17	ml	ml	NN
cord-015021-pol2qm74	2721	18	)	)	-RRB-
cord-015021-pol2qm74	2721	19	without	without	IN
cord-015021-pol2qm74	2721	20	evidence	evidence	NN
cord-015021-pol2qm74	2721	21	of	of	IN
cord-015021-pol2qm74	2721	22	agonist	agonist	NN
cord-015021-pol2qm74	2721	23	activity	activity	NN
cord-015021-pol2qm74	2721	24	.	.	.
cord-015021-pol2qm74	2722	1	In	in	IN
cord-015021-pol2qm74	2722	2	addition	addition	NN
cord-015021-pol2qm74	2722	3	,	,	,
cord-015021-pol2qm74	2722	4	there	there	EX
cord-015021-pol2qm74	2722	5	has	have	VBZ
cord-015021-pol2qm74	2722	6	been	be	VBN
cord-015021-pol2qm74	2722	7	no	no	DT
cord-015021-pol2qm74	2722	8	affect	affect	NN
cord-015021-pol2qm74	2722	9	on	on	IN
cord-015021-pol2qm74	2722	10	normal	normal	JJ
cord-015021-pol2qm74	2722	11	homeostatic	homeostatic	JJ
cord-015021-pol2qm74	2722	12	parameters	parameter	NNS
cord-015021-pol2qm74	2722	13	,	,	,
cord-015021-pol2qm74	2722	14	suggesting	suggest	VBG
cord-015021-pol2qm74	2722	15	that	that	IN
cord-015021-pol2qm74	2722	16	IL	IL	NNP
cord-015021-pol2qm74	2722	17	-	-	:
cord-015021-pol2qm74	2722	18	I	-PRON-	PRP
cord-015021-pol2qm74	2722	19	does	do	VBZ
cord-015021-pol2qm74	2722	20	not	not	RB
cord-015021-pol2qm74	2722	21	play	play	VB
cord-015021-pol2qm74	2722	22	a	a	DT
cord-015021-pol2qm74	2722	23	role	role	NN
cord-015021-pol2qm74	2722	24	in	in	IN
cord-015021-pol2qm74	2722	25	health	health	NN
cord-015021-pol2qm74	2722	26	.	.	.
cord-015021-pol2qm74	2723	1	In	in	IN
cord-015021-pol2qm74	2723	2	healthy	healthy	JJ
cord-015021-pol2qm74	2723	3	humans	human	NNS
cord-015021-pol2qm74	2723	4	given	give	VBN
cord-015021-pol2qm74	2723	5	intravenous	intravenous	JJ
cord-015021-pol2qm74	2723	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2723	7	,	,	,
cord-015021-pol2qm74	2723	8	IL	IL	NNP
cord-015021-pol2qm74	2723	9	-	-	HYPH
cord-015021-pol2qm74	2723	10	IRa	IRa	NNP
cord-015021-pol2qm74	2723	11	reduced	reduce	VBD
cord-015021-pol2qm74	2723	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2723	13	-	-	HYPH
cord-015021-pol2qm74	2723	14	associated	associate	VBN
cord-015021-pol2qm74	2723	15	neutrophilia	neutrophilia	NNS
cord-015021-pol2qm74	2723	16	by	by	IN
cord-015021-pol2qm74	2723	17	50	50	CD
cord-015021-pol2qm74	2723	18	%	%	NN
cord-015021-pol2qm74	2723	19	and	and	CC
cord-015021-pol2qm74	2723	20	completely	completely	RB
cord-015021-pol2qm74	2723	21	reversed	reverse	VBN
cord-015021-pol2qm74	2723	22	endoloxin	endoloxin	JJ
cord-015021-pol2qm74	2723	23	-	-	HYPH
cord-015021-pol2qm74	2723	24	iuduced	iuduced	JJ
cord-015021-pol2qm74	2723	25	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	2723	26	,	,	,
cord-015021-pol2qm74	2723	27	IL	IL	NNP
cord-015021-pol2qm74	2723	28	-	-	HYPH
cord-015021-pol2qm74	2723	29	tRa	tRa	NNP
cord-015021-pol2qm74	2723	30	is	be	VBZ
cord-015021-pol2qm74	2723	31	produced	produce	VBN
cord-015021-pol2qm74	2723	32	naturally	naturally	RB
cord-015021-pol2qm74	2723	33	and	and	CC
cord-015021-pol2qm74	2723	34	is	be	VBZ
cord-015021-pol2qm74	2723	35	elevated	elevate	VBN
cord-015021-pol2qm74	2723	36	in	in	IN
cord-015021-pol2qm74	2723	37	the	the	DT
cord-015021-pol2qm74	2723	38	circulation	circulation	NN
cord-015021-pol2qm74	2723	39	in	in	IN
cord-015021-pol2qm74	2723	40	several	several	JJ
cord-015021-pol2qm74	2723	41	diseases	disease	NNS
cord-015021-pol2qm74	2723	42	.	.	.
cord-015021-pol2qm74	2724	1	In	in	IN
cord-015021-pol2qm74	2724	2	a	a	DT
cord-015021-pol2qm74	2724	3	variety	variety	NN
cord-015021-pol2qm74	2724	4	of	of	IN
cord-015021-pol2qm74	2724	5	diseases	disease	NNS
cord-015021-pol2qm74	2724	6	,	,	,
cord-015021-pol2qm74	2724	7	plasma	plasma	NN
cord-015021-pol2qm74	2724	8	levels	level	NNS
cord-015021-pol2qm74	2724	9	of	of	IN
cord-015021-pol2qm74	2724	10	IL-1Ra	IL-1Ra	NNP
cord-015021-pol2qm74	2724	11	are	be	VBP
cord-015021-pol2qm74	2724	12	in	in	IN
cord-015021-pol2qm74	2724	13	100-fold	100-fold	CD
cord-015021-pol2qm74	2724	14	molar	molar	JJ
cord-015021-pol2qm74	2724	15	excess	excess	NN
cord-015021-pol2qm74	2724	16	to	to	IN
cord-015021-pol2qm74	2724	17	those	those	DT
cord-015021-pol2qm74	2724	18	of	of	IN
cord-015021-pol2qm74	2724	19	IL	IL	NNP
cord-015021-pol2qm74	2724	20	-	-	:
cord-015021-pol2qm74	2724	21	I	I	NNP
cord-015021-pol2qm74	2724	22	[	[	-LRB-
cord-015021-pol2qm74	2724	23	3	3	CD
cord-015021-pol2qm74	2724	24	.	.	.
cord-015021-pol2qm74	2725	1	It	-PRON-	PRP
cord-015021-pol2qm74	2725	2	is	be	VBZ
cord-015021-pol2qm74	2725	3	unclear	unclear	JJ
cord-015021-pol2qm74	2725	4	whether	whether	IN
cord-015021-pol2qm74	2725	5	these	these	DT
cord-015021-pol2qm74	2725	6	endogenous	endogenous	JJ
cord-015021-pol2qm74	2725	7	levels	level	NNS
cord-015021-pol2qm74	2725	8	of	of	IN
cord-015021-pol2qm74	2725	9	IL-1Ra	IL-1Ra	NNP
cord-015021-pol2qm74	2725	10	are	be	VBP
cord-015021-pol2qm74	2725	11	sufficient	sufficient	JJ
cord-015021-pol2qm74	2725	12	to	to	TO
cord-015021-pol2qm74	2725	13	block	block	VB
cord-015021-pol2qm74	2725	14	IL-1	IL-1	NNP
cord-015021-pol2qm74	2725	15	activity	activity	NN
cord-015021-pol2qm74	2725	16	in	in	IN
cord-015021-pol2qm74	2725	17	disease	disease	NN
cord-015021-pol2qm74	2725	18	.	.	.
cord-015021-pol2qm74	2726	1	A	a	DT
cord-015021-pol2qm74	2726	2	single	single	JJ
cord-015021-pol2qm74	2726	3	injection	injection	NN
cord-015021-pol2qm74	2726	4	of	of	IN
cord-015021-pol2qm74	2726	5	]	]	-RRB-
cord-015021-pol2qm74	2726	6	L-6	L-6	NNP
cord-015021-pol2qm74	2726	7	or	or	CC
cord-015021-pol2qm74	2726	8	IFNa	IFNa	NNS
cord-015021-pol2qm74	2726	9	in	in	IN
cord-015021-pol2qm74	2726	10	humans	human	NNS
cord-015021-pol2qm74	2726	11	does	do	VBZ
cord-015021-pol2qm74	2726	12	not	not	RB
cord-015021-pol2qm74	2726	13	induce	induce	VB
cord-015021-pol2qm74	2726	14	IL-1	IL-1	NNP
cord-015021-pol2qm74	2726	15	but	but	CC
cord-015021-pol2qm74	2726	16	rather	rather	RB
cord-015021-pol2qm74	2726	17	high	high	JJ
cord-015021-pol2qm74	2726	18	levels	level	NNS
cord-015021-pol2qm74	2726	19	of	of	IN
cord-015021-pol2qm74	2726	20	IL-1Ra	IL-1Ra	NNP
cord-015021-pol2qm74	2726	21	(	(	-LRB-
cord-015021-pol2qm74	2726	22	10ng	10ng	NNP
cord-015021-pol2qm74	2726	23	/	/	SYM
cord-015021-pol2qm74	2726	24	ml	ml	NN
cord-015021-pol2qm74	2726	25	)	)	-RRB-
cord-015021-pol2qm74	2726	26	.	.	.
cord-015021-pol2qm74	2727	1	Prof.dr	Prof.dr	NNP
cord-015021-pol2qm74	2727	2	.	.	.
cord-015021-pol2qm74	2728	1	L.A.	L.A.	NNP
cord-015021-pol2qm74	2728	2	Aarden	Aarden	NNP
cord-015021-pol2qm74	2728	3	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	2728	4	6	6	CD
cord-015021-pol2qm74	2728	5	(	(	-LRB-
cord-015021-pol2qm74	2728	6	IL6	il6	NN
cord-015021-pol2qm74	2728	7	)	)	-RRB-
cord-015021-pol2qm74	2728	8	is	be	VBZ
cord-015021-pol2qm74	2728	9	a	a	DT
cord-015021-pol2qm74	2728	10	multifunctionaI	multifunctionaI	NNP
cord-015021-pol2qm74	2728	11	cytokine	cytokine	NN
cord-015021-pol2qm74	2728	12	with	with	IN
cord-015021-pol2qm74	2728	13	a	a	DT
cord-015021-pol2qm74	2728	14	central	central	JJ
cord-015021-pol2qm74	2728	15	role	role	NN
cord-015021-pol2qm74	2728	16	in	in	IN
cord-015021-pol2qm74	2728	17	host	host	NN
cord-015021-pol2qm74	2728	18	defense	defense	NN
cord-015021-pol2qm74	2728	19	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2728	20	and	and	CC
cord-015021-pol2qm74	2728	21	consequently	consequently	RB
cord-015021-pol2qm74	2728	22	in	in	IN
cord-015021-pol2qm74	2728	23	inflammation	inflammation	NN
cord-015021-pol2qm74	2728	24	.	.	.
cord-015021-pol2qm74	2729	1	IL6	IL6	NNP
cord-015021-pol2qm74	2729	2	is	be	VBZ
cord-015021-pol2qm74	2729	3	thought	think	VBN
cord-015021-pol2qm74	2729	4	to	to	TO
cord-015021-pol2qm74	2729	5	be	be	VB
cord-015021-pol2qm74	2729	6	involved	involve	VBN
cord-015021-pol2qm74	2729	7	in	in	IN
cord-015021-pol2qm74	2729	8	the	the	DT
cord-015021-pol2qm74	2729	9	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	2729	10	of	of	IN
cord-015021-pol2qm74	2729	11	various	various	JJ
cord-015021-pol2qm74	2729	12	diseases	disease	NNS
cord-015021-pol2qm74	2729	13	.	.	.
cord-015021-pol2qm74	2730	1	Therefore	therefore	RB
cord-015021-pol2qm74	2730	2	,	,	,
cord-015021-pol2qm74	2730	3	specific	specific	JJ
cord-015021-pol2qm74	2730	4	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	2730	5	could	could	MD
cord-015021-pol2qm74	2730	6	have	have	VB
cord-015021-pol2qm74	2730	7	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	2730	8	value	value	NN
cord-015021-pol2qm74	2730	9	.	.	.
cord-015021-pol2qm74	2731	1	A	a	DT
cord-015021-pol2qm74	2731	2	human	human	JJ
cord-015021-pol2qm74	2731	3	-	-	HYPH
cord-015021-pol2qm74	2731	4	mouse	mouse	NN
cord-015021-pol2qm74	2731	5	chimeric	chimeric	JJ
cord-015021-pol2qm74	2731	6	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	2731	7	antibody	antibody	NN
cord-015021-pol2qm74	2731	8	to	to	IN
cord-015021-pol2qm74	2731	9	IL6	IL6	NNP
cord-015021-pol2qm74	2731	10	has	have	VBZ
cord-015021-pol2qm74	2731	11	been	be	VBN
cord-015021-pol2qm74	2731	12	applied	apply	VBN
cord-015021-pol2qm74	2731	13	in	in	IN
cord-015021-pol2qm74	2731	14	a	a	DT
cord-015021-pol2qm74	2731	15	phaseI	phaseI	NNP
cord-015021-pol2qm74	2731	16	clinical	clinical	JJ
cord-015021-pol2qm74	2731	17	trial	trial	NN
cord-015021-pol2qm74	2731	18	in	in	IN
cord-015021-pol2qm74	2731	19	patients	patient	NNS
cord-015021-pol2qm74	2731	20	with	with	IN
cord-015021-pol2qm74	2731	21	multiple	multiple	JJ
cord-015021-pol2qm74	2731	22	myeloma	myeloma	NN
cord-015021-pol2qm74	2731	23	and	and	CC
cord-015021-pol2qm74	2731	24	in	in	IN
cord-015021-pol2qm74	2731	25	primate	primate	JJ
cord-015021-pol2qm74	2731	26	models	model	NNS
cord-015021-pol2qm74	2731	27	of	of	IN
cord-015021-pol2qm74	2731	28	sepsis	sepsis	NN
cord-015021-pol2qm74	2731	29	.	.	.
cord-015021-pol2qm74	2732	1	No	no	DT
cord-015021-pol2qm74	2732	2	toxicity	toxicity	NN
cord-015021-pol2qm74	2732	3	was	be	VBD
cord-015021-pol2qm74	2732	4	observed	observe	VBN
cord-015021-pol2qm74	2732	5	and	and	CC
cord-015021-pol2qm74	2732	6	the	the	DT
cord-015021-pol2qm74	2732	7	most	most	RBS
cord-015021-pol2qm74	2732	8	remarkable	remarkable	JJ
cord-015021-pol2qm74	2732	9	outcome	outcome	NN
cord-015021-pol2qm74	2732	10	of	of	IN
cord-015021-pol2qm74	2732	11	this	this	DT
cord-015021-pol2qm74	2732	12	study	study	NN
cord-015021-pol2qm74	2732	13	was	be	VBD
cord-015021-pol2qm74	2732	14	the	the	DT
cord-015021-pol2qm74	2732	15	build	build	NN
cord-015021-pol2qm74	2732	16	up	up	RP
cord-015021-pol2qm74	2732	17	in	in	IN
cord-015021-pol2qm74	2732	18	the	the	DT
cord-015021-pol2qm74	2732	19	circulation	circulation	NN
cord-015021-pol2qm74	2732	20	of	of	IN
cord-015021-pol2qm74	2732	21	IL6-anti	IL6-anti	NNP
cord-015021-pol2qm74	2732	22	-	-	HYPH
cord-015021-pol2qm74	2732	23	IL6	il6	NN
cord-015021-pol2qm74	2732	24	complexes	complex	NNS
cord-015021-pol2qm74	2732	25	,	,	,
cord-015021-pol2qm74	2732	26	suggesting	suggest	VBG
cord-015021-pol2qm74	2732	27	that	that	IN
cord-015021-pol2qm74	2732	28	plasma	plasma	NN
cord-015021-pol2qm74	2732	29	IL6	il6	NN
cord-015021-pol2qm74	2732	30	measurements	measurement	NNS
cord-015021-pol2qm74	2732	31	represent	represent	VBP
cord-015021-pol2qm74	2732	32	a	a	DT
cord-015021-pol2qm74	2732	33	gross	gross	JJ
cord-015021-pol2qm74	2732	34	underestimation	underestimation	NN
cord-015021-pol2qm74	2732	35	of	of	IN
cord-015021-pol2qm74	2732	36	IL6	il6	NN
cord-015021-pol2qm74	2732	37	production	production	NN
cord-015021-pol2qm74	2732	38	in	in	IN
cord-015021-pol2qm74	2732	39	the	the	DT
cord-015021-pol2qm74	2732	40	patient	patient	NN
cord-015021-pol2qm74	2732	41	.	.	.
cord-015021-pol2qm74	2733	1	Until	until	IN
cord-015021-pol2qm74	2733	2	now	now	RB
cord-015021-pol2qm74	2733	3	no	no	DT
cord-015021-pol2qm74	2733	4	natural	natural	JJ
cord-015021-pol2qm74	2733	5	antagonists	antagonist	NNS
cord-015021-pol2qm74	2733	6	of	of	IN
cord-015021-pol2qm74	2733	7	IL6	IL6	NNP
cord-015021-pol2qm74	2733	8	have	have	VBP
cord-015021-pol2qm74	2733	9	been	be	VBN
cord-015021-pol2qm74	2733	10	described	describe	VBN
cord-015021-pol2qm74	2733	11	.	.	.
cord-015021-pol2qm74	2734	1	The	the	DT
cord-015021-pol2qm74	2734	2	biological	biological	JJ
cord-015021-pol2qm74	2734	3	activities	activity	NNS
cord-015021-pol2qm74	2734	4	of	of	IN
cord-015021-pol2qm74	2734	5	IL6	il6	NN
cord-015021-pol2qm74	2734	6	results	result	VBZ
cord-015021-pol2qm74	2734	7	from	from	IN
cord-015021-pol2qm74	2734	8	binding	bind	VBG
cord-015021-pol2qm74	2734	9	to	to	IN
cord-015021-pol2qm74	2734	10	a	a	DT
cord-015021-pol2qm74	2734	11	lowaffinity	lowaffinity	NN
cord-015021-pol2qm74	2734	12	IL6-receptor	il6-receptor	NN
cord-015021-pol2qm74	2734	13	(	(	-LRB-
cord-015021-pol2qm74	2734	14	IL6R	il6r	NN
cord-015021-pol2qm74	2734	15	)	)	-RRB-
cord-015021-pol2qm74	2734	16	.	.	.
cord-015021-pol2qm74	2735	1	The	the	DT
cord-015021-pol2qm74	2735	2	IL6	IL6	NNP
cord-015021-pol2qm74	2735	3	/	/	SYM
cord-015021-pol2qm74	2735	4	IL6R	IL6R	NNP
cord-015021-pol2qm74	2735	5	complex	complex	NN
cord-015021-pol2qm74	2735	6	induces	induce	VBZ
cord-015021-pol2qm74	2735	7	disulfide	disulfide	RB
cord-015021-pol2qm74	2735	8	-	-	HYPH
cord-015021-pol2qm74	2735	9	linked	link	VBN
cord-015021-pol2qm74	2735	10	homodimerization	homodimerization	NN
cord-015021-pol2qm74	2735	11	of	of	IN
cord-015021-pol2qm74	2735	12	the	the	DT
cord-015021-pol2qm74	2735	13	signal	signal	NN
cord-015021-pol2qm74	2735	14	transducing	transduce	VBG
cord-015021-pol2qm74	2735	15	receptor	receptor	NN
cord-015021-pol2qm74	2735	16	component	component	NN
cord-015021-pol2qm74	2735	17	,	,	,
cord-015021-pol2qm74	2735	18	gp130	gp130	NNS
cord-015021-pol2qm74	2735	19	.	.	.
cord-015021-pol2qm74	2736	1	Studies	study	NNS
cord-015021-pol2qm74	2736	2	on	on	IN
cord-015021-pol2qm74	2736	3	the	the	DT
cord-015021-pol2qm74	2736	4	structure	structure	NN
cord-015021-pol2qm74	2736	5	-	-	HYPH
cord-015021-pol2qm74	2736	6	function	function	NN
cord-015021-pol2qm74	2736	7	relation	relation	NN
cord-015021-pol2qm74	2736	8	of	of	IN
cord-015021-pol2qm74	2736	9	IL6	il6	NN
cord-015021-pol2qm74	2736	10	revealed	reveal	VBD
cord-015021-pol2qm74	2736	11	that	that	IN
cord-015021-pol2qm74	2736	12	disruption	disruption	NN
cord-015021-pol2qm74	2736	13	of	of	IN
cord-015021-pol2qm74	2736	14	the	the	DT
cord-015021-pol2qm74	2736	15	gpl30-interaction	gpl30-interaction	NN
cord-015021-pol2qm74	2736	16	site	site	NN
cord-015021-pol2qm74	2736	17	on	on	IN
cord-015021-pol2qm74	2736	18	IL6	IL6	NNP
cord-015021-pol2qm74	2736	19	gives	give	VBZ
cord-015021-pol2qm74	2736	20	rise	rise	NN
cord-015021-pol2qm74	2736	21	to	to	IN
cord-015021-pol2qm74	2736	22	a	a	DT
cord-015021-pol2qm74	2736	23	mutant	mutant	JJ
cord-015021-pol2qm74	2736	24	IL6	il6	NN
cord-015021-pol2qm74	2736	25	that	that	IN
cord-015021-pol2qm74	2736	26	,	,	,
cord-015021-pol2qm74	2736	27	by	by	IN
cord-015021-pol2qm74	2736	28	virtue	virtue	NN
cord-015021-pol2qm74	2736	29	of	of	IN
cord-015021-pol2qm74	2736	30	its	-PRON-	PRP$
cord-015021-pol2qm74	2736	31	intact	intact	JJ
cord-015021-pol2qm74	2736	32	binding	bind	VBG
cord-015021-pol2qm74	2736	33	to	to	IN
cord-015021-pol2qm74	2736	34	the	the	DT
cord-015021-pol2qm74	2736	35	IL6R	il6r	NN
cord-015021-pol2qm74	2736	36	,	,	,
cord-015021-pol2qm74	2736	37	acts	act	VBZ
cord-015021-pol2qm74	2736	38	as	as	IN
cord-015021-pol2qm74	2736	39	a	a	DT
cord-015021-pol2qm74	2736	40	potent	potent	JJ
cord-015021-pol2qm74	2736	41	antagonist	antagonist	NN
cord-015021-pol2qm74	2736	42	on	on	IN
cord-015021-pol2qm74	2736	43	human	human	JJ
cord-015021-pol2qm74	2736	44	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	2736	45	and	and	CC
cord-015021-pol2qm74	2736	46	on	on	IN
cord-015021-pol2qm74	2736	47	human	human	JJ
cord-015021-pol2qm74	2736	48	B	b	NN
cord-015021-pol2qm74	2736	49	cells	cell	NNS
cord-015021-pol2qm74	2736	50	.	.	.
cord-015021-pol2qm74	2737	1	In	in	IN
cord-015021-pol2qm74	2737	2	vivo	vivo	NN
cord-015021-pol2qm74	2737	3	studies	study	NNS
cord-015021-pol2qm74	2737	4	using	use	VBG
cord-015021-pol2qm74	2737	5	this	this	DT
cord-015021-pol2qm74	2737	6	molecule	molecule	NN
cord-015021-pol2qm74	2737	7	will	will	MD
cord-015021-pol2qm74	2737	8	be	be	VB
cord-015021-pol2qm74	2737	9	initiated	initiate	VBN
cord-015021-pol2qm74	2737	10	in	in	IN
cord-015021-pol2qm74	2737	11	the	the	DT
cord-015021-pol2qm74	2737	12	near	near	JJ
cord-015021-pol2qm74	2737	13	future	future	NN
cord-015021-pol2qm74	2737	14	.	.	.
cord-015021-pol2qm74	2738	1	The	the	DT
cord-015021-pol2qm74	2738	2	evolution	evolution	NN
cord-015021-pol2qm74	2738	3	of	of	IN
cord-015021-pol2qm74	2738	4	infla	infla	NNP
cord-015021-pol2qm74	2738	5	~	~	NFP
cord-015021-pol2qm74	2738	6	ation	ation	NN
cord-015021-pol2qm74	2738	7	involves	involve	VBZ
cord-015021-pol2qm74	2738	8	a	a	DT
cord-015021-pol2qm74	2738	9	dynamic	dynamic	JJ
cord-015021-pol2qm74	2738	10	series	series	NN
cord-015021-pol2qm74	2738	11	of	of	IN
cord-015021-pol2qm74	2738	12	cellular	cellular	JJ
cord-015021-pol2qm74	2738	13	events	event	NNS
cord-015021-pol2qm74	2738	14	controlled	control	VBN
cord-015021-pol2qm74	2738	15	by	by	IN
cord-015021-pol2qm74	2738	16	specific	specific	JJ
cord-015021-pol2qm74	2738	17	signals	signal	NNS
cord-015021-pol2qm74	2738	18	which	which	WDT
cord-015021-pol2qm74	2738	19	are	be	VBP
cord-015021-pol2qm74	2738	20	important	important	JJ
cord-015021-pol2qm74	2738	21	to	to	IN
cord-015021-pol2qm74	2738	22	the	the	DT
cord-015021-pol2qm74	2738	23	initiation	initiation	NN
cord-015021-pol2qm74	2738	24	,	,	,
cord-015021-pol2qm74	2738	25	maintenance	maintenance	NN
cord-015021-pol2qm74	2738	26	,	,	,
cord-015021-pol2qm74	2738	27	and	and	CC
cord-015021-pol2qm74	2738	28	final	final	JJ
cord-015021-pol2qm74	2738	29	resolution	resolution	NN
cord-015021-pol2qm74	2738	30	of	of	IN
cord-015021-pol2qm74	2738	31	the	the	DT
cord-015021-pol2qm74	2738	32	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2738	33	response	response	NN
cord-015021-pol2qm74	2738	34	.	.	.
cord-015021-pol2qm74	2739	1	The	the	DT
cord-015021-pol2qm74	2739	2	various	various	JJ
cord-015021-pol2qm74	2739	3	phases	phase	NNS
cord-015021-pol2qm74	2739	4	of	of	IN
cord-015021-pol2qm74	2739	5	inflammation	inflammation	NN
cord-015021-pol2qm74	2739	6	are	be	VBP
cord-015021-pol2qm74	2739	7	influenced	influence	VBN
cord-015021-pol2qm74	2739	8	via	via	IN
cord-015021-pol2qm74	2739	9	the	the	DT
cord-015021-pol2qm74	2739	10	expression	expression	NN
cord-015021-pol2qm74	2739	11	and	and	CC
cord-015021-pol2qm74	2739	12	subsequent	subsequent	JJ
cord-015021-pol2qm74	2739	13	regulation	regulation	NN
cord-015021-pol2qm74	2739	14	of	of	IN
cord-015021-pol2qm74	2739	15	a	a	DT
cord-015021-pol2qm74	2739	16	number	number	NN
cord-015021-pol2qm74	2739	17	of	of	IN
cord-015021-pol2qm74	2739	18	key	key	JJ
cord-015021-pol2qm74	2739	19	mediators	mediator	NNS
cord-015021-pol2qm74	2739	20	which	which	WDT
cord-015021-pol2qm74	2739	21	play	play	VBP
cord-015021-pol2qm74	2739	22	a	a	DT
cord-015021-pol2qm74	2739	23	predominant	predominant	JJ
cord-015021-pol2qm74	2739	24	role	role	NN
cord-015021-pol2qm74	2739	25	during	during	IN
cord-015021-pol2qm74	2739	26	each	each	DT
cord-015021-pol2qm74	2739	27	particular	particular	JJ
cord-015021-pol2qm74	2739	28	stage	stage	NN
cord-015021-pol2qm74	2739	29	of	of	IN
cord-015021-pol2qm74	2739	30	the	the	DT
cord-015021-pol2qm74	2739	31	developing	develop	VBG
cord-015021-pol2qm74	2739	32	lesion	lesion	NN
cord-015021-pol2qm74	2739	33	.	.	.
cord-015021-pol2qm74	2740	1	For	for	IN
cord-015021-pol2qm74	2740	2	example	example	NN
cord-015021-pol2qm74	2740	3	,	,	,
cord-015021-pol2qm74	2740	4	the	the	DT
cord-015021-pol2qm74	2740	5	initial	initial	JJ
cord-015021-pol2qm74	2740	6	elicitation	elicitation	NN
cord-015021-pol2qm74	2740	7	of	of	IN
cord-015021-pol2qm74	2740	8	blood	blood	NN
cord-015021-pol2qm74	2740	9	born	bear	VBN
cord-015021-pol2qm74	2740	10	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2740	11	to	to	IN
cord-015021-pol2qm74	2740	12	on	on	IN
cord-015021-pol2qm74	2740	13	inflamed	inflamed	JJ
cord-015021-pol2qm74	2740	14	area	area	NN
cord-015021-pol2qm74	2740	15	is	be	VBZ
cord-015021-pol2qm74	2740	16	a	a	DT
cord-015021-pol2qm74	2740	17	complex	complex	JJ
cord-015021-pol2qm74	2740	18	system	system	NN
cord-015021-pol2qm74	2740	19	that	that	WDT
cord-015021-pol2qm74	2740	20	is	be	VBZ
cord-015021-pol2qm74	2740	21	dependent	dependent	JJ
cord-015021-pol2qm74	2740	22	upon	upon	IN
cord-015021-pol2qm74	2740	23	the	the	DT
cord-015021-pol2qm74	2740	24	expression	expression	NN
cord-015021-pol2qm74	2740	25	of	of	IN
cord-015021-pol2qm74	2740	26	early	early	JJ
cord-015021-pol2qm74	2740	27	response	response	NN
cord-015021-pol2qm74	2740	28	cytokineSo	cytokineSo	NFP
cord-015021-pol2qm74	2740	29	These	these	DT
cord-015021-pol2qm74	2740	30	proximal	proximal	JJ
cord-015021-pol2qm74	2740	31	mediators	mediator	NNS
cord-015021-pol2qm74	2740	32	,	,	,
cord-015021-pol2qm74	2740	33	including	include	VBG
cord-015021-pol2qm74	2740	34	both	both	CC
cord-015021-pol2qm74	2740	35	interleukin	interleukin	NN
cord-015021-pol2qm74	2740	36	-	-	:
cord-015021-pol2qm74	2740	37	i	i	JJ
cord-015021-pol2qm74	2740	38	(	(	-LRB-
cord-015021-pol2qm74	2740	39	IL	IL	NNP
cord-015021-pol2qm74	2740	40	-	-	HYPH
cord-015021-pol2qm74	2740	41	I	I	NNP
cord-015021-pol2qm74	2740	42	)	)	-RRB-
cord-015021-pol2qm74	2740	43	and	and	CC
cord-015021-pol2qm74	2740	44	tumor	tumor	NN
cord-015021-pol2qm74	2740	45	necroisis	necroisis	NN
cord-015021-pol2qm74	2740	46	factor	factor	NN
cord-015021-pol2qm74	2740	47	(	(	-LRB-
cord-015021-pol2qm74	2740	48	TNF	TNF	NNP
cord-015021-pol2qm74	2740	49	)	)	-RRB-
cord-015021-pol2qm74	2740	50	,	,	,
cord-015021-pol2qm74	2740	51	are	be	VBP
cord-015021-pol2qm74	2740	52	important	important	JJ
cord-015021-pol2qm74	2740	53	in	in	IN
cord-015021-pol2qm74	2740	54	the	the	DT
cord-015021-pol2qm74	2740	55	initiation	initiation	NN
cord-015021-pol2qm74	2740	56	phase	phase	NN
cord-015021-pol2qm74	2740	57	by	by	IN
cord-015021-pol2qm74	2740	58	activating	activate	VBG
cord-015021-pol2qm74	2740	59	both	both	DT
cord-015021-pol2qm74	2740	60	immune	immune	JJ
cord-015021-pol2qm74	2740	61	and	and	CC
cord-015021-pol2qm74	2740	62	non	non	JJ
cord-015021-pol2qm74	2740	63	-	-	JJ
cord-015021-pol2qm74	2740	64	immune	immune	JJ
cord-015021-pol2qm74	2740	65	cells	cell	NNS
cord-015021-pol2qm74	2740	66	and	and	CC
cord-015021-pol2qm74	2740	67	establishing	establish	VBG
cord-015021-pol2qm74	2740	68	a	a	DT
cord-015021-pol2qm74	2740	69	series	series	NN
cord-015021-pol2qm74	2740	70	of	of	IN
cord-015021-pol2qm74	2740	71	cytokine	cytokine	NN
cord-015021-pol2qm74	2740	72	networks	network	NNS
cord-015021-pol2qm74	2740	73	,	,	,
cord-015021-pol2qm74	2740	74	Thus	thus	RB
cord-015021-pol2qm74	2740	75	,	,	,
cord-015021-pol2qm74	2740	76	the	the	DT
cord-015021-pol2qm74	2740	77	above	above	JJ
cord-015021-pol2qm74	2740	78	proximal	proximal	JJ
cord-015021-pol2qm74	2740	79	mediators	mediator	NNS
cord-015021-pol2qm74	2740	80	can	can	MD
cord-015021-pol2qm74	2740	81	stimulate	stimulate	VB
cord-015021-pol2qm74	2740	82	endothelial	endothelial	JJ
cord-015021-pol2qm74	2740	83	cells	cell	NNS
cord-015021-pol2qm74	2740	84	,	,	,
cord-015021-pol2qm74	2740	85	epithelial	epithelial	JJ
cord-015021-pol2qm74	2740	86	cells	cell	NNS
cord-015021-pol2qm74	2740	87	,	,	,
cord-015021-pol2qm74	2740	88	smooth	smooth	JJ
cord-015021-pol2qm74	2740	89	muscle	muscle	NN
cord-015021-pol2qm74	2740	90	cells	cell	NNS
cord-015021-pol2qm74	2740	91	,	,	,
cord-015021-pol2qm74	2740	92	and	and	CC
cord-015021-pol2qm74	2740	93	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	2740	94	to	to	TO
cord-015021-pol2qm74	2740	95	generate	generate	VB
cord-015021-pol2qm74	2740	96	more	more	JJR
cord-015021-pol2qm74	2740	97	distal	distal	JJ
cord-015021-pol2qm74	2740	98	cytokines	cytokine	NNS
cord-015021-pol2qm74	2740	99	.	.	.
cord-015021-pol2qm74	2741	1	These	these	DT
cord-015021-pol2qm74	2741	2	latter	latter	JJ
cord-015021-pol2qm74	2741	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	2741	4	include	include	VBP
cord-015021-pol2qm74	2741	5	interleukin-8	interleukin-8	NNP
cord-015021-pol2qm74	2741	6	(	(	-LRB-
cord-015021-pol2qm74	2741	7	IL-8	IL-8	NNP
cord-015021-pol2qm74	2741	8	)	)	-RRB-
cord-015021-pol2qm74	2741	9	,	,	,
cord-015021-pol2qm74	2741	10	macrophage	macrophage	NN
cord-015021-pol2qm74	2741	11	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2741	12	protein	protein	NN
cord-015021-pol2qm74	2741	13	-	-	:
cord-015021-pol2qm74	2741	14	i	i	NNP
cord-015021-pol2qm74	2741	15	(	(	-LRB-
cord-015021-pol2qm74	2741	16	MIP	MIP	NNP
cord-015021-pol2qm74	2741	17	-	-	HYPH
cord-015021-pol2qm74	2741	18	I	I	NNP
cord-015021-pol2qm74	2741	19	)	)	-RRB-
cord-015021-pol2qm74	2741	20	,	,	,
cord-015021-pol2qm74	2741	21	and	and	CC
cord-015021-pol2qm74	2741	22	monocyte	monocyte	NNP
cord-015021-pol2qm74	2741	23	cbemoattractant	cbemoattractant	NNP
cord-015021-pol2qm74	2741	24	protein	protein	NNP
cord-015021-pol2qm74	2742	1	-i	-i	NFP
cord-015021-pol2qm74	2742	2	(	(	-LRB-
cord-015021-pol2qm74	2742	3	MCP	MCP	NNP
cord-015021-pol2qm74	2742	4	-	-	HYPH
cord-015021-pol2qm74	2742	5	I	I	NNP
cord-015021-pol2qm74	2742	6	)	)	-RRB-
cord-015021-pol2qm74	2742	7	.	.	.
cord-015021-pol2qm74	2743	1	The	the	DT
cord-015021-pol2qm74	2743	2	importance	importance	NN
cord-015021-pol2qm74	2743	3	of	of	IN
cord-015021-pol2qm74	2743	4	the	the	DT
cord-015021-pol2qm74	2743	5	above	above	JJ
cord-015021-pol2qm74	2743	6	chemukines	chemukine	NNS
cord-015021-pol2qm74	2743	7	can	can	MD
cord-015021-pol2qm74	2743	8	be	be	VB
cord-015021-pol2qm74	2743	9	found	find	VBN
cord-015021-pol2qm74	2743	10	in	in	IN
cord-015021-pol2qm74	2743	11	the	the	DT
cord-015021-pol2qm74	2743	12	role	role	NN
cord-015021-pol2qm74	2743	13	they	-PRON-	PRP
cord-015021-pol2qm74	2743	14	play	play	VBP
cord-015021-pol2qm74	2743	15	in	in	IN
cord-015021-pol2qm74	2743	16	leukocyte	leukocyte	NN
cord-015021-pol2qm74	2743	17	elicitation	elicitation	NN
cord-015021-pol2qm74	2743	18	,	,	,
cord-015021-pol2qm74	2743	19	as	as	RB
cord-015021-pol2qm74	2743	20	well	well	RB
cord-015021-pol2qm74	2743	21	as	as	IN
cord-015021-pol2qm74	2743	22	wound	wound	NN
cord-015021-pol2qm74	2743	23	repair	repair	NN
cord-015021-pol2qm74	2743	24	.	.	.
cord-015021-pol2qm74	2744	1	Numerous	numerous	JJ
cord-015021-pol2qm74	2744	2	investigations	investigation	NNS
cord-015021-pol2qm74	2744	3	have	have	VBP
cord-015021-pol2qm74	2744	4	shown	show	VBN
cord-015021-pol2qm74	2744	5	the	the	DT
cord-015021-pol2qm74	2744	6	diverse	diverse	JJ
cord-015021-pol2qm74	2744	7	cellular	cellular	JJ
cord-015021-pol2qm74	2744	8	sources	source	NNS
cord-015021-pol2qm74	2744	9	of	of	IN
cord-015021-pol2qm74	2744	10	IL-8	IL-8	NNP
cord-015021-pol2qm74	2744	11	and	and	CC
cord-015021-pol2qm74	2744	12	the	the	DT
cord-015021-pol2qm74	2744	13	ability	ability	NN
cord-015021-pol2qm74	2744	14	of	of	IN
cord-015021-pol2qm74	2744	15	IL-8	IL-8	NNP
cord-015021-pol2qm74	2744	16	to	to	TO
cord-015021-pol2qm74	2744	17	elicit	elicit	VB
cord-015021-pol2qm74	2744	18	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2744	19	in	in	IN
cord-015021-pol2qm74	2744	20	vitro	vitro	FW
cord-015021-pol2qm74	2744	21	at	at	IN
cord-015021-pol2qm74	2744	22	pM	pm	NN
cord-015021-pol2qm74	2744	23	to	to	IN
cord-015021-pol2qm74	2744	24	nM	nm	CD
cord-015021-pol2qm74	2744	25	concentrations	concentration	NNS
cord-015021-pol2qm74	2744	26	,	,	,
cord-015021-pol2qm74	2744	27	however	however	RB
cord-015021-pol2qm74	2744	28	,	,	,
cord-015021-pol2qm74	2744	29	recent	recent	JJ
cord-015021-pol2qm74	2744	30	studies	study	NNS
cord-015021-pol2qm74	2744	31	have	have	VBP
cord-015021-pol2qm74	2744	32	sho%~	sho%~	CD
cord-015021-pol2qm74	2744	33	an	an	DT
cord-015021-pol2qm74	2744	34	additional	additional	JJ
cord-015021-pol2qm74	2744	35	role	role	NN
cord-015021-pol2qm74	2744	36	for	for	IN
cord-015021-pol2qm74	2744	37	IL-8	IL-8	NNP
cord-015021-pol2qm74	2744	38	during	during	IN
cord-015021-pol2qm74	2744	39	the	the	DT
cord-015021-pol2qm74	2744	40	resolution	resolution	NN
cord-015021-pol2qm74	2744	41	phase	phase	NN
cord-015021-pol2qm74	2744	42	of	of	IN
cord-015021-pol2qm74	2744	43	the	the	DT
cord-015021-pol2qm74	2744	44	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2744	45	process	process	NN
cord-015021-pol2qm74	2744	46	.	.	.
cord-015021-pol2qm74	2745	1	Using	use	VBG
cord-015021-pol2qm74	2745	2	corneal	corneal	JJ
cord-015021-pol2qm74	2745	3	pocket	pocket	NN
cord-015021-pol2qm74	2745	4	animal	animal	NN
cord-015021-pol2qm74	2745	5	models	model	NNS
cord-015021-pol2qm74	2745	6	of	of	IN
cord-015021-pol2qm74	2745	7	angiogenesis	angiogenesis	NN
cord-015021-pol2qm74	2745	8	/	/	SYM
cord-015021-pol2qm74	2745	9	neovascularization	neovascularization	NN
cord-015021-pol2qm74	2745	10	,	,	,
cord-015021-pol2qm74	2745	11	IL-8	IL-8	NNP
cord-015021-pol2qm74	2745	12	was	be	VBD
cord-015021-pol2qm74	2745	13	found	find	VBN
cord-015021-pol2qm74	2745	14	to	to	TO
cord-015021-pol2qm74	2745	15	be	be	VB
cord-015021-pol2qm74	2745	16	a	a	DT
cord-015021-pol2qm74	2745	17	potent	potent	JJ
cord-015021-pol2qm74	2745	18	angiogenic	angiogenic	JJ
cord-015021-pol2qm74	2745	19	factor	factor	NN
cord-015021-pol2qm74	2745	20	at	at	IN
cord-015021-pol2qm74	2745	21	concentrations	concentration	NNS
cord-015021-pol2qm74	2745	22	ranging	range	VBG
cord-015021-pol2qm74	2745	23	from	from	IN
cord-015021-pol2qm74	2745	24	2	2	CD
cord-015021-pol2qm74	2745	25	-	-	HYPH
cord-015021-pol2qm74	2745	26	40ng	40ng	JJ
cord-015021-pol2qm74	2745	27	/	/	SYM
cord-015021-pol2qm74	2745	28	ml	ml	NN
cord-015021-pol2qm74	2745	29	.	.	.
cord-015021-pol2qm74	2746	1	Sequential	sequential	JJ
cord-015021-pol2qm74	2746	2	fluorescein	fluorescein	NNP
cord-015021-pol2qm74	2746	3	angiograms	angiogram	NNS
cord-015021-pol2qm74	2746	4	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	2746	5	that	that	IN
cord-015021-pol2qm74	2746	6	IL-8	IL-8	NNP
cord-015021-pol2qm74	2746	7	induced	induce	VBD
cord-015021-pol2qm74	2746	8	neovascularization	neovascularization	NN
cord-015021-pol2qm74	2746	9	by	by	IN
cord-015021-pol2qm74	2746	10	14	14	CD
cord-015021-pol2qm74	2746	11	days	day	NNS
cord-015021-pol2qm74	2746	12	,	,	,
cord-015021-pol2qm74	2746	13	which	which	WDT
cord-015021-pol2qm74	2746	14	regressed	regress	VBD
cord-015021-pol2qm74	2746	15	by	by	IN
cord-015021-pol2qm74	2746	16	6	6	CD
cord-015021-pol2qm74	2746	17	weeks	week	NNS
cord-015021-pol2qm74	2746	18	.	.	.
cord-015021-pol2qm74	2747	1	In	in	IN
cord-015021-pol2qm74	2747	2	further	further	JJ
cord-015021-pol2qm74	2747	3	analyses	analysis	NNS
cord-015021-pol2qm74	2747	4	,	,	,
cord-015021-pol2qm74	2747	5	both	both	DT
cord-015021-pol2qm74	2747	6	conditioned	condition	VBN
cord-015021-pol2qm74	2747	7	media	medium	NNS
cord-015021-pol2qm74	2747	8	recovered	recover	VBD
cord-015021-pol2qm74	2747	9	from	from	IN
cord-015021-pol2qm74	2747	10	either	either	CC
cord-015021-pol2qm74	2747	11	inflamed	inflamed	JJ
cord-015021-pol2qm74	2747	12	human	human	JJ
cord-015021-pol2qm74	2747	13	heumatoid	heumatoid	NN
cord-015021-pol2qm74	2747	14	synovial	synovial	JJ
cord-015021-pol2qm74	2747	15	tissue	tissue	NN
cord-015021-pol2qm74	2747	16	macrophages	macrophage	NNS
cord-015021-pol2qm74	2747	17	or	or	CC
cord-015021-pol2qm74	2747	18	LPS	LPS	NNP
cord-015021-pol2qm74	2747	19	-	-	HYPH
cord-015021-pol2qm74	2747	20	stimulated	stimulate	VBN
cord-015021-pol2qm74	2747	21	peripheral	peripheral	JJ
cord-015021-pol2qm74	2747	22	blood	blood	NN
cord-015021-pol2qm74	2747	23	monocytes	monocyte	NNS
cord-015021-pol2qm74	2747	24	were	be	VBD
cord-015021-pol2qm74	2747	25	found	find	VBN
cord-015021-pol2qm74	2747	26	to	to	TO
cord-015021-pol2qm74	2747	27	possess	possess	VB
cord-015021-pol2qm74	2747	28	potent	potent	JJ
cord-015021-pol2qm74	2747	29	angiogenic	angiogenic	JJ
cord-015021-pol2qm74	2747	30	activity	activity	NN
cord-015021-pol2qm74	2747	31	,	,	,
cord-015021-pol2qm74	2747	32	which	which	WDT
cord-015021-pol2qm74	2747	33	was	be	VBD
cord-015021-pol2qm74	2747	34	effectively	effectively	RB
cord-015021-pol2qm74	2747	35	blocked	block	VBN
cord-015021-pol2qm74	2747	36	by	by	IN
cord-015021-pol2qm74	2747	37	neutralizing	neutralize	VBG
cord-015021-pol2qm74	2747	38	antibodies	antibody	NNS
cord-015021-pol2qm74	2747	39	directed	direct	VBN
cord-015021-pol2qm74	2747	40	against	against	IN
cord-015021-pol2qm74	2747	41	human	human	JJ
cord-015021-pol2qm74	2747	42	IL-8	il-8	NN
cord-015021-pol2qm74	2747	43	.	.	.
cord-015021-pol2qm74	2748	1	In	in	IN
cord-015021-pol2qm74	2748	2	addition	addition	NN
cord-015021-pol2qm74	2748	3	,	,	,
cord-015021-pol2qm74	2748	4	an	an	DT
cord-015021-pol2qm74	2748	5	IL-8	IL-8	NNP
cord-015021-pol2qm74	2748	6	antisense	antisense	NN
cord-015021-pol2qm74	2748	7	nligomunclentide	nligomunclentide	NN
cord-015021-pol2qm74	2748	8	blocked	block	VBD
cord-015021-pol2qm74	2748	9	the	the	DT
cord-015021-pol2qm74	2748	10	expression	expression	NN
cord-015021-pol2qm74	2748	11	of	of	IN
cord-015021-pol2qm74	2748	12	a	a	DT
cord-015021-pol2qm74	2748	13	functionally	functionally	RB
cord-015021-pol2qm74	2748	14	active	active	JJ
cord-015021-pol2qm74	2748	15	angiogenic	angiogenic	JJ
cord-015021-pol2qm74	2748	16	factor	factor	NN
cord-015021-pol2qm74	2748	17	from	from	IN
cord-015021-pol2qm74	2748	18	LPS	LPS	NNP
cord-015021-pol2qm74	2748	19	treated	treat	VBN
cord-015021-pol2qm74	2748	20	monocytes	monocyte	NNS
cord-015021-pol2qm74	2748	21	.	.	.
cord-015021-pol2qm74	2749	1	The	the	DT
cord-015021-pol2qm74	2749	2	above	above	JJ
cord-015021-pol2qm74	2749	3	data	datum	NNS
cord-015021-pol2qm74	2749	4	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2749	5	that	that	IN
cord-015021-pol2qm74	2749	6	IL-8	IL-8	NNP
cord-015021-pol2qm74	2749	7	has	have	VBZ
cord-015021-pol2qm74	2749	8	multifumctional	multifumctional	JJ
cord-015021-pol2qm74	2749	9	activities	activity	NNS
cord-015021-pol2qm74	2749	10	during	during	IN
cord-015021-pol2qm74	2749	11	the	the	DT
cord-015021-pol2qm74	2749	12	initiation	initiation	NN
cord-015021-pol2qm74	2749	13	,	,	,
cord-015021-pol2qm74	2749	14	maintenance	maintenance	NN
cord-015021-pol2qm74	2749	15	,	,	,
cord-015021-pol2qm74	2749	16	and	and	CC
cord-015021-pol2qm74	2749	17	resolution	resolution	NN
cord-015021-pol2qm74	2749	18	of	of	IN
cord-015021-pol2qm74	2749	19	a	a	DT
cord-015021-pol2qm74	2749	20	local	local	JJ
cord-015021-pol2qm74	2749	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2749	22	response	response	NN
cord-015021-pol2qm74	2749	23	.	.	.
cord-015021-pol2qm74	2750	1	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2750	2	specific	specific	JJ
cord-015021-pol2qm74	2750	3	T	t	NN
cord-015021-pol2qm74	2750	4	-	-	HYPH
cord-015021-pol2qm74	2750	5	cell	cell	NN
cord-015021-pol2qm74	2750	6	responses	response	NNS
cord-015021-pol2qm74	2750	7	to	to	IN
cord-015021-pol2qm74	2750	8	soluble	soluble	JJ
cord-015021-pol2qm74	2750	9	protein	protein	NN
cord-015021-pol2qm74	2750	10	antigens	antigen	NNS
cord-015021-pol2qm74	2750	11	and	and	CC
cord-015021-pol2qm74	2750	12	alloantigens	alloantigen	NNS
cord-015021-pol2qm74	2750	13	.	.	.
cord-015021-pol2qm74	2751	1	The	the	DT
cord-015021-pol2qm74	2751	2	proliferative	proliferative	JJ
cord-015021-pol2qm74	2751	3	responses	response	NNS
cord-015021-pol2qm74	2751	4	of	of	IN
cord-015021-pol2qm74	2751	5	Th0	th0	CD
cord-015021-pol2qm74	2751	6	,	,	,
cord-015021-pol2qm74	2751	7	Thl	Thl	NNP
cord-015021-pol2qm74	2751	8	and	and	CC
cord-015021-pol2qm74	2751	9	Th2	th2	CD
cord-015021-pol2qm74	2751	10	CD4	CD4	NNP
cord-015021-pol2qm74	2751	11	÷	÷	NNP
cord-015021-pol2qm74	2751	12	T	T	NNP
cord-015021-pol2qm74	2751	13	-	-	HYPH
cord-015021-pol2qm74	2751	14	cell	cell	NN
cord-015021-pol2qm74	2751	15	clones	clone	NNS
cord-015021-pol2qm74	2751	16	and	and	CC
cord-015021-pol2qm74	2751	17	cytokine	cytokine	NN
cord-015021-pol2qm74	2751	18	production	production	NN
cord-015021-pol2qm74	2751	19	by	by	IN
cord-015021-pol2qm74	2751	20	these	these	DT
cord-015021-pol2qm74	2751	21	T	t	NN
cord-015021-pol2qm74	2751	22	-	-	HYPH
cord-015021-pol2qm74	2751	23	cell	cell	NN
cord-015021-pol2qm74	2751	24	subsets	subset	NNS
cord-015021-pol2qm74	2751	25	are	be	VBP
cord-015021-pol2qm74	2751	26	equally	equally	RB
cord-015021-pol2qm74	2751	27	well	well	RB
cord-015021-pol2qm74	2751	28	inhibited	inhibited	JJ
cord-015021-pol2qm74	2751	29	.	.	.
cord-015021-pol2qm74	2752	1	The	the	DT
cord-015021-pol2qm74	2752	2	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	2752	3	effects	effect	NNS
cord-015021-pol2qm74	2752	4	of	of	IN
cord-015021-pol2qm74	2752	5	IL-10	IL-10	NNP
cord-015021-pol2qm74	2752	6	are	be	VBP
cord-015021-pol2qm74	2752	7	indirect	indirect	JJ
cord-015021-pol2qm74	2752	8	and	and	CC
cord-015021-pol2qm74	2752	9	related	relate	VBN
cord-015021-pol2qm74	2752	10	to	to	IN
cord-015021-pol2qm74	2752	11	inhibition	inhibition	NN
cord-015021-pol2qm74	2752	12	of	of	IN
cord-015021-pol2qm74	2752	13	antigen	antigen	NN
cord-015021-pol2qm74	2752	14	-	-	HYPH
cord-015021-pol2qm74	2752	15	presenting	present	VBG
cord-015021-pol2qm74	2752	16	capacity	capacity	NN
cord-015021-pol2qm74	2752	17	and	and	CC
cord-015021-pol2qm74	2752	18	accessory	accessory	NN
cord-015021-pol2qm74	2752	19	function	function	NN
cord-015021-pol2qm74	2752	20	of	of	IN
cord-015021-pol2qm74	2752	21	the	the	DT
cord-015021-pol2qm74	2752	22	antigen	antigen	NN
cord-015021-pol2qm74	2752	23	-	-	HYPH
cord-015021-pol2qm74	2752	24	presenting	present	VBG
cord-015021-pol2qm74	2752	25	cells	cell	NNS
cord-015021-pol2qm74	2752	26	(	(	-LRB-
cord-015021-pol2qm74	2752	27	APC	APC	NNP
cord-015021-pol2qm74	2752	28	)	)	-RRB-
cord-015021-pol2qm74	2752	29	.	.	.
cord-015021-pol2qm74	2753	1	However	however	RB
cord-015021-pol2qm74	2753	2	,	,	,
cord-015021-pol2qm74	2753	3	IL-10	IL-10	NNP
cord-015021-pol2qm74	2753	4	also	also	RB
cord-015021-pol2qm74	2753	5	directly	directly	RB
cord-015021-pol2qm74	2753	6	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2753	7	T	t	NN
cord-015021-pol2qm74	2753	8	-	-	HYPH
cord-015021-pol2qm74	2753	9	cell	cell	NN
cord-015021-pol2qm74	2753	10	proli	proli	NN
cord-015021-pol2qm74	2753	11	/	/	SYM
cord-015021-pol2qm74	2753	12	eration	eration	NN
cord-015021-pol2qm74	2753	13	induced	induce	VBN
cord-015021-pol2qm74	2753	14	by	by	IN
cord-015021-pol2qm74	2753	15	cross]inked	cross]inked	``
cord-015021-pol2qm74	2753	16	anti	anti	NNP
cord-015021-pol2qm74	2753	17	-	-	JJ
cord-015021-pol2qm74	2753	18	CD3	cd3	JJ
cord-015021-pol2qm74	2753	19	or	or	CC
cord-015021-pol2qm74	2753	20	anti	anti	JJ
cord-015021-pol2qm74	2753	21	-	-	NNP
cord-015021-pol2qm74	2753	22	CD2	CD2	NNP
cord-015021-pol2qm74	2753	23	mAbs	mAbs	NNP
cord-015021-pol2qm74	2754	1	(	(	-LRB-
cord-015021-pol2qm74	2754	2	e.g.	e.g.	RB
cord-015021-pol2qm74	2754	3	in	in	IN
cord-015021-pol2qm74	2754	4	the	the	DT
cord-015021-pol2qm74	2754	5	absence	absence	NN
cord-015021-pol2qm74	2754	6	of	of	IN
cord-015021-pol2qm74	2754	7	professional	professional	JJ
cord-015021-pol2qm74	2754	8	APC	APC	NNP
cord-015021-pol2qm74	2754	9	)	)	-RRB-
cord-015021-pol2qm74	2754	10	,	,	,
cord-015021-pol2qm74	2754	11	by	by	IN
cord-015021-pol2qm74	2754	12	specifically	specifically	RB
cord-015021-pol2qm74	2754	13	inhibiting	inhibit	VBG
cord-015021-pol2qm74	2754	14	IL-2	il-2	NN
cord-015021-pol2qm74	2754	15	gene	gene	NN
cord-015021-pol2qm74	2754	16	transcription	transcription	NN
cord-015021-pol2qm74	2754	17	and	and	CC
cord-015021-pol2qm74	2754	18	IL-2	IL-2	NNP
cord-015021-pol2qm74	2754	19	protein	protein	NN
cord-015021-pol2qm74	2754	20	production	production	NN
cord-015021-pol2qm74	2754	21	.	.	.
cord-015021-pol2qm74	2754	22	IL-10	IL-10	NNP
cord-015021-pol2qm74	2754	23	also	also	RB
cord-015021-pol2qm74	2754	24	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2754	25	the	the	DT
cord-015021-pol2qm74	2754	26	production	production	NN
cord-015021-pol2qm74	2754	27	of	of	IN
cord-015021-pol2qm74	2754	28	the	the	DT
cord-015021-pol2qm74	2754	29	pro	pro	JJ
cord-015021-pol2qm74	2754	30	-	-	JJ
cord-015021-pol2qm74	2754	31	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2754	32	cytokines	cytokine	NNS
cord-015021-pol2qm74	2754	33	IL	IL	NNP
cord-015021-pol2qm74	2754	34	-	-	HYPH
cord-015021-pol2qm74	2754	35	l	l	NN
cord-015021-pol2qm74	2754	36	-	-	HYPH
cord-015021-pol2qm74	2754	37	a	a	NN
cord-015021-pol2qm74	2754	38	,	,	,
cord-015021-pol2qm74	2754	39	~	~	NFP
cord-015021-pol2qm74	2754	40	,	,	,
cord-015021-pol2qm74	2754	41	IL-6	IL-6	NNP
cord-015021-pol2qm74	2754	42	,	,	,
cord-015021-pol2qm74	2754	43	and	and	CC
cord-015021-pol2qm74	2754	44	TNF	TNF	NNP
cord-015021-pol2qm74	2754	45	-	-	,
cord-015021-pol2qm74	2754	46	a	a	NNP
cord-015021-pol2qm74	2754	47	and	and	CC
cord-015021-pol2qm74	2754	48	the	the	DT
cord-015021-pol2qm74	2754	49	chemokines	chemokine	NNS
cord-015021-pol2qm74	2754	50	IL-8	IL-8	NNP
cord-015021-pol2qm74	2754	51	and	and	CC
cord-015021-pol2qm74	2754	52	MIP	MIP	NNP
cord-015021-pol2qm74	2754	53	-	-	HYPH
cord-015021-pol2qm74	2754	54	I	I	NNP
cord-015021-pol2qm74	2754	55	-	-	HYPH
cord-015021-pol2qm74	2754	56	u	u	NNP
cord-015021-pol2qm74	2754	57	,	,	,
cord-015021-pol2qm74	2754	58	which	which	WDT
cord-015021-pol2qm74	2754	59	are	be	VBP
cord-015021-pol2qm74	2754	60	strong	strong	JJ
cord-015021-pol2qm74	2754	61	chemo	chemo	NN
cord-015021-pol2qm74	2754	62	attractants	attractant	NNS
cord-015021-pol2qm74	2754	63	for	for	IN
cord-015021-pol2qm74	2754	64	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2754	65	and	and	CC
cord-015021-pol2qm74	2754	66	macrophage	macrophage	NN
cord-015021-pol2qm74	2754	67	,	,	,
cord-015021-pol2qm74	2754	68	respectively	respectively	RB
cord-015021-pol2qm74	2754	69	.	.	.
cord-015021-pol2qm74	2755	1	In	in	IN
cord-015021-pol2qm74	2755	2	contrast	contrast	NN
cord-015021-pol2qm74	2755	3	,	,	,
cord-015021-pol2qm74	2755	4	IL-10	IL-10	NNP
cord-015021-pol2qm74	2755	5	enhances	enhance	VBZ
cord-015021-pol2qm74	2755	6	the	the	DT
cord-015021-pol2qm74	2755	7	production	production	NN
cord-015021-pol2qm74	2755	8	of	of	IN
cord-015021-pol2qm74	2755	9	the	the	DT
cord-015021-pol2qm74	2755	10	IL-1	IL-1	NNP
cord-015021-pol2qm74	2755	11	receptor	receptor	NN
cord-015021-pol2qm74	2755	12	antagonist	antagonist	NN
cord-015021-pol2qm74	2755	13	,	,	,
cord-015021-pol2qm74	2755	14	a	a	DT
cord-015021-pol2qm74	2755	15	cytokine	cytokine	NN
cord-015021-pol2qm74	2755	16	with	with	IN
cord-015021-pol2qm74	2755	17	anti	anti	JJ
cord-015021-pol2qm74	2755	18	-	-	JJ
cord-015021-pol2qm74	2755	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2755	20	activity	activity	NN
cord-015021-pol2qm74	2755	21	.	.	.
cord-015021-pol2qm74	2756	1	IL	IL	NNP
cord-015021-pol2qm74	2756	2	-	-	HYPH
cord-015021-pol2qm74	2756	3	l0	l0	NNP
cord-015021-pol2qm74	2756	4	produced	produce	VBN
cord-015021-pol2qm74	2756	5	by	by	IN
cord-015021-pol2qm74	2756	6	monocytes	monocyte	NNS
cord-015021-pol2qm74	2756	7	downregulates	downregulate	VBZ
cord-015021-pol2qm74	2756	8	class	class	NN
cord-015021-pol2qm74	2756	9	II	II	NNP
cord-015021-pol2qm74	2756	10	MHC	MHC	NNP
cord-015021-pol2qm74	2756	11	expression	expression	NN
cord-015021-pol2qm74	2756	12	and	and	CC
cord-015021-pol2qm74	2756	13	IL-10	IL-10	NNP
cord-015021-pol2qm74	2756	14	production	production	NN
cord-015021-pol2qm74	2756	15	by	by	IN
cord-015021-pol2qm74	2756	16	these	these	DT
cord-015021-pol2qm74	2756	17	cells	cell	NNS
cord-015021-pol2qm74	2756	18	in	in	IN
cord-015021-pol2qm74	2756	19	an	an	DT
cord-015021-pol2qm74	2756	20	autoregulatory	autoregulatory	JJ
cord-015021-pol2qm74	2756	21	fashion	fashion	NN
cord-015021-pol2qm74	2756	22	.	.	.
cord-015021-pol2qm74	2757	1	Collectively	collectively	RB
cord-015021-pol2qm74	2757	2	,	,	,
cord-015021-pol2qm74	2757	3	these	these	DT
cord-015021-pol2qm74	2757	4	in	in	IN
cord-015021-pol2qm74	2757	5	vitro	vitro	FW
cord-015021-pol2qm74	2757	6	data	datum	NNS
cord-015021-pol2qm74	2757	7	indicate	indicate	VBP
cord-015021-pol2qm74	2757	8	that	that	IN
cord-015021-pol2qm74	2757	9	IL-10	IL-10	NNP
cord-015021-pol2qm74	2757	10	is	be	VBZ
cord-015021-pol2qm74	2757	11	a	a	DT
cord-015021-pol2qm74	2757	12	powerful	powerful	JJ
cord-015021-pol2qm74	2757	13	suppressor	suppressor	NN
cord-015021-pol2qm74	2757	14	factor	factor	NN
cord-015021-pol2qm74	2757	15	for	for	IN
cord-015021-pol2qm74	2757	16	immune	immune	NN
cord-015021-pol2qm74	2757	17	-	-	HYPH
cord-015021-pol2qm74	2757	18	and	and	CC
cord-015021-pol2qm74	2757	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2757	20	responses	response	NNS
cord-015021-pol2qm74	2757	21	and	and	CC
cord-015021-pol2qm74	2757	22	therefore	therefore	RB
cord-015021-pol2qm74	2757	23	may	may	MD
cord-015021-pol2qm74	2757	24	have	have	VB
cord-015021-pol2qm74	2757	25	potential	potential	JJ
cord-015021-pol2qm74	2757	26	clinical	clinical	JJ
cord-015021-pol2qm74	2757	27	utility	utility	NN
cord-015021-pol2qm74	2757	28	as	as	IN
cord-015021-pol2qm74	2757	29	an	an	DT
cord-015021-pol2qm74	2757	30	anti	anti	JJ
cord-015021-pol2qm74	2757	31	-	-	JJ
cord-015021-pol2qm74	2757	32	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2757	33	agent	agent	NN
cord-015021-pol2qm74	2757	34	.	.	.
cord-015021-pol2qm74	2758	1	This	this	DT
cord-015021-pol2qm74	2758	2	notion	notion	NN
cord-015021-pol2qm74	2758	3	is	be	VBZ
cord-015021-pol2qm74	2758	4	supported	support	VBN
cord-015021-pol2qm74	2758	5	by	by	IN
cord-015021-pol2qm74	2758	6	recent	recent	JJ
cord-015021-pol2qm74	2758	7	studies	study	NNS
cord-015021-pol2qm74	2758	8	which	which	WDT
cord-015021-pol2qm74	2758	9	indicated	indicate	VBD
cord-015021-pol2qm74	2758	10	that	that	IN
cord-015021-pol2qm74	2758	11	IL-10	IL-10	NNP
cord-015021-pol2qm74	2758	12	also	also	RB
cord-015021-pol2qm74	2758	13	prevents	prevent	VBZ
cord-015021-pol2qm74	2758	14	lethal	lethal	JJ
cord-015021-pol2qm74	2758	15	LPS	lp	NNS
cord-015021-pol2qm74	2758	16	-	-	HYPH
cord-015021-pol2qm74	2758	17	induced	induce	VBN
cord-015021-pol2qm74	2758	18	toxic	toxic	JJ
cord-015021-pol2qm74	2758	19	shock	shock	NN
cord-015021-pol2qm74	2758	20	in	in	IN
cord-015021-pol2qm74	2758	21	mice	mouse	NNS
cord-015021-pol2qm74	2758	22	.	.	.
cord-015021-pol2qm74	2759	1	Five	five	CD
cord-015021-pol2qm74	2759	2	of	of	IN
cord-015021-pol2qm74	2759	3	the	the	DT
cord-015021-pol2qm74	2759	4	chamekines	chamekine	NNS
cord-015021-pol2qm74	2759	5	(	(	-LRB-
cord-015021-pol2qm74	2759	6	HIP	HIP	NNP
cord-015021-pol2qm74	2759	7	-	-	HYPH
cord-015021-pol2qm74	2759	8	I~,eRA	I~,eRA	NNP
cord-015021-pol2qm74	2759	9	~	~	NFP
cord-015021-pol2qm74	2759	10	TES	TES	NNP
cord-015021-pol2qm74	2759	11	.	.	.
cord-015021-pol2qm74	2760	1	IP	IP	NNP
cord-015021-pol2qm74	2760	2	-	-	HYPH
cord-015021-pol2qm74	2760	3	IO	IO	NNP
cord-015021-pol2qm74	2760	4	and	and	CC
cord-015021-pol2qm74	2760	5	IL	IL	NNP
cord-015021-pol2qm74	2760	6	8)	8)	NNP
cord-015021-pol2qm74	2760	7	also	also	RB
cord-015021-pol2qm74	2760	8	chemoattraet	chemoattraet	NNP
cord-015021-pol2qm74	2760	9	T	t	NN
cord-015021-pol2qm74	2760	10	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2760	11	,	,	,
cord-015021-pol2qm74	2760	12	while	while	IN
cord-015021-pol2qm74	2760	13	others	other	NNS
cord-015021-pol2qm74	2760	14	act	act	VBP
cord-015021-pol2qm74	2760	15	on	on	IN
cord-015021-pol2qm74	2760	16	mast	mast	NN
cord-015021-pol2qm74	2760	17	cells	cell	NNS
cord-015021-pol2qm74	2760	18	.	.	.
cord-015021-pol2qm74	2761	1	We	-PRON-	PRP
cord-015021-pol2qm74	2761	2	have	have	VBP
cord-015021-pol2qm74	2761	3	studied	study	VBN
cord-015021-pol2qm74	2761	4	the	the	DT
cord-015021-pol2qm74	2761	5	effaces	efface	NNS
cord-015021-pol2qm74	2761	6	of	of	IN
cord-015021-pol2qm74	2761	7	these	these	DT
cord-015021-pol2qm74	2761	8	chemokines	chemokine	NNS
cord-015021-pol2qm74	2761	9	on	on	IN
cord-015021-pol2qm74	2761	10	T	T	NNP
cord-015021-pol2qm74	2761	11	cell	cell	NN
cord-015021-pol2qm74	2761	12	subsets	subset	NNS
cord-015021-pol2qm74	2761	13	.	.	.
cord-015021-pol2qm74	2762	1	IL	IL	NNP
cord-015021-pol2qm74	2762	2	8	8	CD
cord-015021-pol2qm74	2762	3	preferentially	preferentially	RB
cord-015021-pol2qm74	2762	4	chemoattracts	chemoattract	VBZ
cord-015021-pol2qm74	2762	5	uns	uns	NNPS
cord-015021-pol2qm74	2762	6	~	~	NFP
cord-015021-pol2qm74	2762	7	imulated	imulated	JJ
cord-015021-pol2qm74	2762	8	T	T	NNP
cord-015021-pol2qm74	2762	9	Cells	Cells	NNPS
cord-015021-pol2qm74	2762	10	.	.	.
cord-015021-pol2qm74	2763	1	RAISES	raise	VBZ
cord-015021-pol2qm74	2763	2	~ttracte	~ttracte	NFP
cord-015021-pol2qm74	2763	3	resting	rest	VBG
cord-015021-pol2qm74	2763	4	as	as	RB
cord-015021-pol2qm74	2763	5	well	well	RB
cord-015021-pol2qm74	2763	6	as	as	IN
cord-015021-pol2qm74	2763	7	activated	activate	VBN
cord-015021-pol2qm74	2763	8	CD4	CD4	NNP
cord-015021-pol2qm74	2763	9	and	and	CC
cord-015021-pol2qm74	2763	10	CD8	CD8	NNP
cord-015021-pol2qm74	2763	11	memory	memory	NN
cord-015021-pol2qm74	2763	12	T	T	NNP
cord-015021-pol2qm74	2763	13	cells	cell	NNS
cord-015021-pol2qm74	2763	14	.	.	.
cord-015021-pol2qm74	2764	1	IP-10	IP-10	NNP
cord-015021-pol2qm74	2764	2	chemoattracts	chemoattract	VBZ
cord-015021-pol2qm74	2764	3	only	only	RB
cord-015021-pol2qm74	2764	4	preactivated	preactivate	VBN
cord-015021-pol2qm74	2764	5	(	(	-LRB-
cord-015021-pol2qm74	2764	6	not	not	RB
cord-015021-pol2qm74	2764	7	resting	rest	VBG
cord-015021-pol2qm74	2764	8	)	)	-RRB-
cord-015021-pol2qm74	2765	1	CD4	CD4	NNP
cord-015021-pol2qm74	2765	2	or	or	CC
cord-015021-pol2qm74	2765	3	CD8	CD8	NNP
cord-015021-pol2qm74	2765	4	T	T	NNP
cord-015021-pol2qm74	2765	5	cells	cell	NNS
cord-015021-pol2qm74	2765	6	.	.	.
cord-015021-pol2qm74	2766	1	HIP	HIP	NNP
cord-015021-pol2qm74	2766	2	-	-	HYPH
cord-015021-pol2qm74	2766	3	l~	l~	XX
cord-015021-pol2qm74	2766	4	preferentially	preferentially	RB
cord-015021-pol2qm74	2766	5	chemoattracts	chemoattract	VBZ
cord-015021-pol2qm74	2766	6	GD8	GD8	NNP
cord-015021-pol2qm74	2766	7	T	T	NNP
cord-015021-pol2qm74	2766	8	calla	calla	NN
cord-015021-pol2qm74	2766	9	,	,	,
cord-015021-pol2qm74	2766	10	while	while	IN
cord-015021-pol2qm74	2766	11	HIP-18	HIP-18	NNP
cord-015021-pol2qm74	2766	12	more	more	RBR
cord-015021-pol2qm74	2766	13	readily	readily	RB
cord-015021-pol2qm74	2766	14	attracts	attract	VBZ
cord-015021-pol2qm74	2766	15	the	the	DT
cord-015021-pol2qm74	2766	16	CD4	CD4	NNP
cord-015021-pol2qm74	2766	17	T	T	NNP
cord-015021-pol2qm74	2766	18	call	call	NN
cord-015021-pol2qm74	2766	19	subset	subset	JJ
cord-015021-pol2qm74	2766	20	.	.	.
cord-015021-pol2qm74	2767	1	The	the	DT
cord-015021-pol2qm74	2767	2	8	8	CD
cord-015021-pol2qm74	2767	3	chemoklnes	chemoklne	NNS
cord-015021-pol2qm74	2767	4	and	and	CC
cord-015021-pol2qm74	2767	5	IP	IP	NNP
cord-015021-pol2qm74	2767	6	-	-	HYPH
cord-015021-pol2qm74	2767	7	IO	IO	NNP
cord-015021-pol2qm74	2767	8	were	be	VBD
cord-015021-pol2qm74	2767	9	also	also	RB
cord-015021-pol2qm74	2767	10	sho	sho	NNP
cord-015021-pol2qm74	2767	11	~	~	NFP
cord-015021-pol2qm74	2767	12	rn	rn	NN
cord-015021-pol2qm74	2767	13	to	to	TO
cord-015021-pol2qm74	2767	14	promote	promote	VB
cord-015021-pol2qm74	2767	15	the	the	DT
cord-015021-pol2qm74	2767	16	adherence	adherence	NN
cord-015021-pol2qm74	2767	17	of	of	IN
cord-015021-pol2qm74	2767	18	~he	~he	JJ
cord-015021-pol2qm74	2767	19	same	same	JJ
cord-015021-pol2qm74	2767	20	subsets	subset	NNS
cord-015021-pol2qm74	2767	21	of	of	IN
cord-015021-pol2qm74	2767	22	anti	anti	JJ
cord-015021-pol2qm74	2767	23	-	-	NNP
cord-015021-pol2qm74	2767	24	CD3	CD3	NNP
cord-015021-pol2qm74	2767	25	activated	activate	VBN
cord-015021-pol2qm74	2767	26	T	T	NNP
cord-015021-pol2qm74	2767	27	cells	cell	NNS
cord-015021-pol2qm74	2767	28	to	to	IN
cord-015021-pol2qm74	2767	29	ILI	ILI	NNP
cord-015021-pol2qm74	2767	30	activated	activate	VBD
cord-015021-pol2qm74	2767	31	human	human	JJ
cord-015021-pol2qm74	2767	32	umbilical	umbilical	JJ
cord-015021-pol2qm74	2767	33	vein	vein	NN
cord-015021-pol2qm74	2767	34	endothelial	endothelial	JJ
cord-015021-pol2qm74	2767	35	cells	cell	NNS
cord-015021-pol2qm74	2767	36	(	(	-LRB-
cord-015021-pol2qm74	2767	37	HITVEC	HITVEC	NNP
cord-015021-pol2qm74	2767	38	)	)	-RRB-
cord-015021-pol2qm74	2767	39	.	.	.
cord-015021-pol2qm74	2768	1	This	this	DT
cord-015021-pol2qm74	2768	2	was	be	VBD
cord-015021-pol2qm74	2768	3	not	not	RB
cord-015021-pol2qm74	2768	4	associated	associate	VBN
cord-015021-pol2qm74	2768	5	with	with	IN
cord-015021-pol2qm74	2768	6	a	a	DT
cord-015021-pol2qm74	2768	7	~	~	NNP
cord-015021-pol2qm74	2768	8	y	y	NNP
cord-015021-pol2qm74	2768	9	i~	i~	CD
cord-015021-pol2qm74	2769	1	crease	crease	VB
cord-015021-pol2qm74	2769	2	in	in	IN
cord-015021-pol2qm74	2769	3	the	the	DT
cord-015021-pol2qm74	2769	4	number	number	NN
cord-015021-pol2qm74	2769	5	of	of	IN
cord-015021-pol2qm74	2769	6	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	2769	7	adhesion	adhesion	NN
cord-015021-pol2qm74	2769	8	molecules	molecule	NNS
cord-015021-pol2qm74	2769	9	,	,	,
cord-015021-pol2qm74	2769	10	bu~	bu~	FW
cord-015021-pol2qm74	2769	11	could	could	MD
cord-015021-pol2qm74	2769	12	be	be	VB
cord-015021-pol2qm74	2769	13	inhibited	inhibit	VBN
cord-015021-pol2qm74	2769	14	by	by	IN
cord-015021-pol2qm74	2769	15	neutralizing	neutralize	VBG
cord-015021-pol2qm74	2769	16	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	2769	17	antibodies	antibody	NNS
cord-015021-pol2qm74	2769	18	re	re	IN
cord-015021-pol2qm74	2769	19	LFA	LFA	NNP
cord-015021-pol2qm74	2769	20	-	-	HYPH
cord-015021-pol2qm74	2769	21	I	I	NNP
cord-015021-pol2qm74	2769	22	and	and	CC
cord-015021-pol2qm74	2769	23	VLA-4	VLA-4	NNP
cord-015021-pol2qm74	2769	24	.	.	.
cord-015021-pol2qm74	2770	1	These	these	DT
cord-015021-pol2qm74	2770	2	chemokines	chemokine	NNS
cord-015021-pol2qm74	2770	3	also	also	RB
cord-015021-pol2qm74	2770	4	rapidly	rapidly	RB
cord-015021-pol2qm74	2770	5	increased	increase	VBD
cord-015021-pol2qm74	2770	6	~ha	~ha	JJ
cord-015021-pol2qm74	2770	7	adhesion	adhesion	NN
cord-015021-pol2qm74	2770	8	of	of	IN
cord-015021-pol2qm74	2770	9	resting	rest	VBG
cord-015021-pol2qm74	2770	10	T	T	NNP
cord-015021-pol2qm74	2770	11	l	l	NNP
cord-015021-pol2qm74	2770	12	~	~	NFP
cord-015021-pol2qm74	2770	13	phoeytes	phoeyte	NNS
cord-015021-pol2qm74	2770	14	to	to	IN
cord-015021-pol2qm74	2770	15	plates	plate	NNS
cord-015021-pol2qm74	2770	16	coated	coat	VBD
cord-015021-pol2qm74	2770	17	wi	wi	NNP
cord-015021-pol2qm74	2771	1	~h	~h	NNP
cord-015021-pol2qm74	2771	2	8	8	CD
cord-015021-pol2qm74	2771	3	integrlns	integrln	NNS
cord-015021-pol2qm74	2771	4	(	(	-LRB-
cord-015021-pol2qm74	2771	5	I	I	NNP
cord-015021-pol2qm74	2771	6	-	-	HYPH
cord-015021-pol2qm74	2771	7	CAM	CAM	NNP
cord-015021-pol2qm74	2771	8	or	or	CC
cord-015021-pol2qm74	2771	9	V	v	NN
cord-015021-pol2qm74	2771	10	-	-	HYPH
cord-015021-pol2qm74	2771	11	CAM	cam	NN
cord-015021-pol2qm74	2771	12	)	)	-RRB-
cord-015021-pol2qm74	2771	13	or	or	CC
cord-015021-pol2qm74	2771	14	matrix	matrix	NN
cord-015021-pol2qm74	2771	15	proteins	protein	NNS
cord-015021-pol2qm74	2771	16	such	such	JJ
cord-015021-pol2qm74	2771	17	as	as	IN
cord-015021-pol2qm74	2771	18	f	f	NNP
cord-015021-pol2qm74	2771	19	~	~	NFP
cord-015021-pol2qm74	2771	20	bronectln	bronectln	NNP
cord-015021-pol2qm74	2771	21	.	.	.
cord-015021-pol2qm74	2772	1	This	this	DT
cord-015021-pol2qm74	2772	2	induction	induction	NN
cord-015021-pol2qm74	2772	3	of	of	IN
cord-015021-pol2qm74	2772	4	adhesion	adhesion	NN
cord-015021-pol2qm74	2772	5	began	begin	VBD
cord-015021-pol2qm74	2772	6	wiEhln	wiEhln	NNP
cord-015021-pol2qm74	2772	7	30	30	CD
cord-015021-pol2qm74	2772	8	'	'	''
cord-015021-pol2qm74	2772	9	,	,	,
cord-015021-pol2qm74	2772	10	peaked	peak	VBD
cord-015021-pol2qm74	2772	11	by	by	IN
cord-015021-pol2qm74	2772	12	1	1	CD
cord-015021-pol2qm74	2772	13	hr	hr	NN
cord-015021-pol2qm74	2772	14	and	and	CC
cord-015021-pol2qm74	2772	15	was	be	VBD
cord-015021-pol2qm74	2772	16	completed	complete	VBN
cord-015021-pol2qm74	2772	17	in	in	IN
cord-015021-pol2qm74	2772	18	3	3	CD
cord-015021-pol2qm74	2772	19	hr	hr	NN
cord-015021-pol2qm74	2772	20	.	.	.
cord-015021-pol2qm74	2773	1	This	this	DT
cord-015021-pol2qm74	2773	2	suggests	suggest	VBZ
cord-015021-pol2qm74	2773	3	that	that	IN
cord-015021-pol2qm74	2773	4	chemoklnee	chemoklnee	FW
cord-015021-pol2qm74	2773	5	rapldly	rapldly	RB
cord-015021-pol2qm74	2773	6	increase	increase	VBP
cord-015021-pol2qm74	2773	7	the	the	DT
cord-015021-pol2qm74	2773	8	binding	bind	VBG
cord-015021-pol2qm74	2773	9	affinity	affinity	NN
cord-015021-pol2qm74	2773	10	of	of	IN
cord-015021-pol2qm74	2773	11	adhesion	adhesion	NN
cord-015021-pol2qm74	2773	12	prote	prote	NNP
cord-015021-pol2qm74	2773	13	~	~	NFP
cord-015021-pol2qm74	2773	14	ns	ns	XX
cord-015021-pol2qm74	2773	15	on	on	IN
cord-015021-pol2qm74	2773	16	T	t	NN
cord-015021-pol2qm74	2773	17	cells	cell	NNS
cord-015021-pol2qm74	2773	18	.	.	.
cord-015021-pol2qm74	2774	1	We	-PRON-	PRP
cord-015021-pol2qm74	2774	2	also	also	RB
cord-015021-pol2qm74	2774	3	recently	recently	RB
cord-015021-pol2qm74	2774	4	observed	observe	VBD
cord-015021-pol2qm74	2774	5	~hat	~hat	XX
cord-015021-pol2qm74	2775	1	MCAF	MCAF	NNP
cord-015021-pol2qm74	2775	2	/	/	SYM
cord-015021-pol2qm74	2775	3	MCPI	MCPI	NNP
cord-015021-pol2qm74	2775	4	and	and	CC
cord-015021-pol2qm74	2775	5	RANTES	RANTES	NNP
cord-015021-pol2qm74	2775	6	chemoattract	chemoattract	NNP
cord-015021-pol2qm74	2775	7	unatimulated	unatimulate	VBN
cord-015021-pol2qm74	2775	8	mast	mast	NN
cord-015021-pol2qm74	2775	9	calls	call	NNS
cord-015021-pol2qm74	2775	10	.	.	.
cord-015021-pol2qm74	2776	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2776	2	,	,	,
cord-015021-pol2qm74	2776	3	IgS	IgS	NNP
cord-015021-pol2qm74	2776	4	actlvared	actlvared	JJ
cord-015021-pol2qm74	2776	5	mast	mast	NN
cord-015021-pol2qm74	2776	6	calls	call	NNS
cord-015021-pol2qm74	2776	7	were	be	VBD
cord-015021-pol2qm74	2776	8	chemoattraeted	chemoattraete	VBN
cord-015021-pol2qm74	2776	9	by	by	IN
cord-015021-pol2qm74	2776	10	MCAF	MCAF	NNP
cord-015021-pol2qm74	2776	11	,	,	,
cord-015021-pol2qm74	2776	12	RA	RA	NNP
cord-015021-pol2qm74	2776	13	~	~	NNP
cord-015021-pol2qm74	2776	14	TES	TES	NNP
cord-015021-pol2qm74	2776	15	,	,	,
cord-015021-pol2qm74	2776	16	PF4	pf4	NN
cord-015021-pol2qm74	2776	17	and	and	CC
cord-015021-pol2qm74	2776	18	MIP.I~.	mip.i~.	NN
cord-015021-pol2qm74	2776	19	However	however	RB
cord-015021-pol2qm74	2776	20	.	.	.
cord-015021-pol2qm74	2777	1	~he	~he	NNP
cord-015021-pol2qm74	2777	2	chemoklnee	chemoklnee	NNP
cord-015021-pol2qm74	2777	3	did	do	VBD
cord-015021-pol2qm74	2777	4	not	not	RB
cord-015021-pol2qm74	2777	5	induce	induce	VB
cord-015021-pol2qm74	2777	6	mast	mast	NN
cord-015021-pol2qm74	2777	7	cells	cell	NNS
cord-015021-pol2qm74	2777	8	~o	~o	NNP
cord-015021-pol2qm74	2777	9	release	release	NN
cord-015021-pol2qm74	2777	10	histamines	histamine	NNS
cord-015021-pol2qm74	2777	11	.	.	.
cord-015021-pol2qm74	2778	1	Presumably	presumably	RB
cord-015021-pol2qm74	2778	2	,	,	,
cord-015021-pol2qm74	2778	3	chemokines	chemokine	NNS
cord-015021-pol2qm74	2778	4	as	as	IN
cord-015021-pol2qm74	2778	5	regulators	regulator	NNS
cord-015021-pol2qm74	2778	6	of	of	IN
cord-015021-pol2qm74	2778	7	the	the	DT
cord-015021-pol2qm74	2778	8	adhesion	adhesion	NN
cord-015021-pol2qm74	2778	9	,	,	,
cord-015021-pol2qm74	2778	10	migration	migration	NN
cord-015021-pol2qm74	2778	11	and	and	CC
cord-015021-pol2qm74	2778	12	homing	homing	NN
cord-015021-pol2qm74	2778	13	of	of	IN
cord-015021-pol2qm74	2778	14	all	all	DT
cord-015021-pol2qm74	2778	15	kinds	kind	NNS
cord-015021-pol2qm74	2778	16	of	of	IN
cord-015021-pol2qm74	2778	17	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2778	18	participate	participate	VBP
cord-015021-pol2qm74	2778	19	in	in	IN
cord-015021-pol2qm74	2778	20	many	many	JJ
cord-015021-pol2qm74	2778	21	types	type	NNS
cord-015021-pol2qm74	2778	22	of	of	IN
cord-015021-pol2qm74	2778	23	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2778	24	diseases	disease	NNS
cord-015021-pol2qm74	2778	25	.	.	.
cord-015021-pol2qm74	2779	1	Natural	natural	JJ
cord-015021-pol2qm74	2779	2	killer	killer	NN
cord-015021-pol2qm74	2779	3	cell	cell	NN
cord-015021-pol2qm74	2779	4	stimulatory	stimulatory	JJ
cord-015021-pol2qm74	2779	5	factor	factor	NN
cord-015021-pol2qm74	2779	6	or	or	CC
cord-015021-pol2qm74	2779	7	interleukin-12	interleukin-12	XX
cord-015021-pol2qm74	2779	8	(	(	-LRB-
cord-015021-pol2qm74	2779	9	IL-12	IL-12	NNP
cord-015021-pol2qm74	2779	10	)	)	-RRB-
cord-015021-pol2qm74	2779	11	is	be	VBZ
cord-015021-pol2qm74	2779	12	an	an	DT
cord-015021-pol2qm74	2779	13	heterodimerie	heterodimerie	NNP
cord-015021-pol2qm74	2779	14	cytokine	cytokine	NN
cord-015021-pol2qm74	2779	15	formed	form	VBN
cord-015021-pol2qm74	2779	16	by	by	IN
cord-015021-pol2qm74	2779	17	two	two	CD
cord-015021-pol2qm74	2779	18	covalently	covalently	RB
cord-015021-pol2qm74	2779	19	linked	link	VBN
cord-015021-pol2qm74	2779	20	glycosylated	glycosylated	JJ
cord-015021-pol2qm74	2779	21	chains	chain	NNS
cord-015021-pol2qm74	2779	22	of	of	IN
cord-015021-pol2qm74	2779	23	35kD	35kd	CD
cord-015021-pol2qm74	2779	24	and	and	CC
cord-015021-pol2qm74	2779	25	40	40	CD
cord-015021-pol2qm74	2779	26	kD.	kd.	NN
cord-015021-pol2qm74	2779	27	IL-12	IL-12	NNP
cord-015021-pol2qm74	2779	28	was	be	VBD
cord-015021-pol2qm74	2779	29	originally	originally	RB
cord-015021-pol2qm74	2779	30	purified	purify	VBN
cord-015021-pol2qm74	2779	31	from	from	IN
cord-015021-pol2qm74	2779	32	the	the	DT
cord-015021-pol2qm74	2779	33	supermatant	supermatant	JJ
cord-015021-pol2qm74	2779	34	fluids	fluid	NNS
cord-015021-pol2qm74	2779	35	of	of	IN
cord-015021-pol2qm74	2779	36	EBV	EBV	NNP
cord-015021-pol2qm74	2779	37	-	-	HYPH
cord-015021-pol2qm74	2779	38	transformed	transform	VBN
cord-015021-pol2qm74	2779	39	human	human	NN
cord-015021-pol2qm74	2779	40	B	b	NN
cord-015021-pol2qm74	2779	41	ly	ly	NNP
cord-015021-pol2qm74	2779	42	~	~	NFP
cord-015021-pol2qm74	2779	43	phobiastoid	phobiastoid	NNP
cord-015021-pol2qm74	2779	44	cell	cell	NN
cord-015021-pol2qm74	2779	45	lines	line	NNS
cord-015021-pol2qm74	2779	46	.	.	.
cord-015021-pol2qm74	2780	1	However	however	RB
cord-015021-pol2qm74	2780	2	,	,	,
cord-015021-pol2qm74	2780	3	in	in	IN
cord-015021-pol2qm74	2780	4	addition	addition	NN
cord-015021-pol2qm74	2780	5	to	to	IN
cord-015021-pol2qm74	2780	6	B	b	NN
cord-015021-pol2qm74	2780	7	cells	cell	NNS
cord-015021-pol2qm74	2780	8	,	,	,
cord-015021-pol2qm74	2780	9	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2780	10	cells	cell	NNS
cord-015021-pol2qm74	2780	11	,	,	,
cord-015021-pol2qm74	2780	12	i.e.	i.e.	FW
cord-015021-pol2qm74	2780	13	monocytes	monocyte	NNS
cord-015021-pol2qm74	2780	14	,	,	,
cord-015021-pol2qm74	2780	15	macrophages	macrophage	NNS
cord-015021-pol2qm74	2780	16	,	,	,
cord-015021-pol2qm74	2780	17	and	and	CC
cord-015021-pol2qm74	2780	18	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2780	19	,	,	,
cord-015021-pol2qm74	2780	20	have	have	VBP
cord-015021-pol2qm74	2780	21	been	be	VBN
cord-015021-pol2qm74	2780	22	identified	identify	VBN
cord-015021-pol2qm74	2780	23	as	as	IN
cord-015021-pol2qm74	2780	24	the	the	DT
cord-015021-pol2qm74	2780	25	major	major	JJ
cord-015021-pol2qm74	2780	26	physiological	physiological	JJ
cord-015021-pol2qm74	2780	27	producers	producer	NNS
cord-015021-pol2qm74	2780	28	of	of	IN
cord-015021-pol2qm74	2780	29	IL-12	IL-12	NNP
cord-015021-pol2qm74	2780	30	.	.	.
cord-015021-pol2qm74	2781	1	Phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2781	2	cells	cell	NNS
cord-015021-pol2qm74	2781	3	produce	produce	VBP
cord-015021-pol2qm74	2781	4	IL-12	IL-12	NNP
cord-015021-pol2qm74	2781	5	in	in	IN
cord-015021-pol2qm74	2781	6	response	response	NN
cord-015021-pol2qm74	2781	7	to	to	IN
cord-015021-pol2qm74	2781	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	2781	9	,	,	,
cord-015021-pol2qm74	2781	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	2781	11	products	product	NNS
cord-015021-pol2qm74	2781	12	such	such	JJ
cord-015021-pol2qm74	2781	13	as	as	IN
cord-015021-pol2qm74	2781	14	LPS	LPS	NNP
cord-015021-pol2qm74	2781	15	,	,	,
cord-015021-pol2qm74	2781	16	and	and	CC
cord-015021-pol2qm74	2781	17	intracellular	intracellular	JJ
cord-015021-pol2qm74	2781	18	parasites	parasite	NNS
cord-015021-pol2qm74	2781	19	.	.	.
cord-015021-pol2qm74	2782	1	The	the	DT
cord-015021-pol2qm74	2782	2	cell	cell	NN
cord-015021-pol2qm74	2782	3	types	type	NNS
cord-015021-pol2qm74	2782	4	on	on	IN
cord-015021-pol2qm74	2782	5	which	which	WDT
cord-015021-pol2qm74	2782	6	IL-12	IL-12	NNP
cord-015021-pol2qm74	2782	7	exert	exert	VB
cord-015021-pol2qm74	2782	8	biological	biological	JJ
cord-015021-pol2qm74	2782	9	activity	activity	NN
cord-015021-pol2qm74	2782	10	are	be	VBP
cord-015021-pol2qm74	2782	11	T	T	NNP
cord-015021-pol2qm74	2782	12	and	and	CC
cord-015021-pol2qm74	2782	13	NK	NK	NNP
cord-015021-pol2qm74	2782	14	cells	cell	NNS
cord-015021-pol2qm74	2782	15	.	.	.
cord-015021-pol2qm74	2783	1	The	the	DT
cord-015021-pol2qm74	2783	2	major	major	JJ
cord-015021-pol2qm74	2783	3	direct	direct	JJ
cord-015021-pol2qm74	2783	4	biological	biological	JJ
cord-015021-pol2qm74	2783	5	function	function	NN
cord-015021-pol2qm74	2783	6	of	of	IN
cord-015021-pol2qm74	2783	7	IL-12	IL-12	NNP
cord-015021-pol2qm74	2783	8	on	on	IN
cord-015021-pol2qm74	2783	9	these	these	DT
cord-015021-pol2qm74	2783	10	cell	cell	NN
cord-015021-pol2qm74	2783	11	types	type	NNS
cord-015021-pol2qm74	2783	12	are	be	VBP
cord-015021-pol2qm74	2783	13	the	the	DT
cord-015021-pol2qm74	2783	14	induction	induction	NN
cord-015021-pol2qm74	2783	15	of	of	IN
cord-015021-pol2qm74	2783	16	cytokine	cytokine	NN
cord-015021-pol2qm74	2783	17	production	production	NN
cord-015021-pol2qm74	2783	18	,	,	,
cord-015021-pol2qm74	2783	19	primarily	primarily	RB
cord-015021-pol2qm74	2783	20	IFN	IFN	NNP
cord-015021-pol2qm74	2783	21	-	-	HYPH
cord-015021-pol2qm74	2783	22	y	y	NNP
cord-015021-pol2qm74	2783	23	,	,	,
cord-015021-pol2qm74	2783	24	the	the	DT
cord-015021-pol2qm74	2783	25	enhancement	enhancement	NN
cord-015021-pol2qm74	2783	26	of	of	IN
cord-015021-pol2qm74	2783	27	a	a	DT
cord-015021-pol2qm74	2783	28	generation	generation	NN
cord-015021-pol2qm74	2783	29	of	of	IN
cord-015021-pol2qm74	2783	30	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	2783	31	cells	cell	NNS
cord-015021-pol2qm74	2783	32	,	,	,
cord-015021-pol2qm74	2783	33	and	and	CC
cord-015021-pol2qm74	2783	34	a	a	DT
cord-015021-pol2qm74	2783	35	mitogenic	mitogenic	JJ
cord-015021-pol2qm74	2783	36	effect	effect	NN
cord-015021-pol2qm74	2783	37	on	on	IN
cord-015021-pol2qm74	2783	38	antlgen	antlgen	NN
cord-015021-pol2qm74	2783	39	-	-	HYPH
cord-015021-pol2qm74	2783	40	activated	activate	VBN
cord-015021-pol2qm74	2783	41	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2783	42	.	.	.
cord-015021-pol2qm74	2784	1	In	in	IN
cord-015021-pol2qm74	2784	2	part	part	NN
cord-015021-pol2qm74	2784	3	thromgh	thromgh	VBZ
cord-015021-pol2qm74	2784	4	its	-PRON-	PRP$
cord-015021-pol2qm74	2784	5	ability	ability	NN
cord-015021-pol2qm74	2784	6	to	to	TO
cord-015021-pol2qm74	2784	7	induce	induce	VB
cord-015021-pol2qm74	2784	8	IFN	IFN	NNP
cord-015021-pol2qm74	2784	9	-	-	HYPH
cord-015021-pol2qm74	2784	10	y	y	NNP
cord-015021-pol2qm74	2784	11	production	production	NN
cord-015021-pol2qm74	2784	12	,	,	,
cord-015021-pol2qm74	2785	1	IL-12	IL-12	NNP
cord-015021-pol2qm74	2785	2	,	,	,
cord-015021-pol2qm74	2785	3	produced	produce	VBN
cord-015021-pol2qm74	2785	4	in	in	IN
cord-015021-pol2qm74	2785	5	response	response	NN
cord-015021-pol2qm74	2785	6	to	to	IN
cord-015021-pol2qm74	2785	7	infections	infection	NNS
cord-015021-pol2qm74	2785	8	,	,	,
cord-015021-pol2qm74	2785	9	represents	represent	VBZ
cord-015021-pol2qm74	2785	10	an	an	DT
cord-015021-pol2qm74	2785	11	important	important	JJ
cord-015021-pol2qm74	2785	12	functional	functional	JJ
cord-015021-pol2qm74	2785	13	link	link	NN
cord-015021-pol2qm74	2785	14	between	between	IN
cord-015021-pol2qm74	2785	15	effector	effector	NN
cord-015021-pol2qm74	2785	16	cells	cell	NNS
cord-015021-pol2qm74	2785	17	of	of	IN
cord-015021-pol2qm74	2785	18	innate	innate	JJ
cord-015021-pol2qm74	2785	19	resistance	resistance	NN
cord-015021-pol2qm74	2785	20	,	,	,
cord-015021-pol2qm74	2785	21	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2785	22	cells	cell	NNS
cord-015021-pol2qm74	2785	23	and	and	CC
cord-015021-pol2qm74	2785	24	NK	NK	NNP
cord-015021-pol2qm74	2785	25	cells	cell	NNS
cord-015021-pol2qm74	2785	26	,	,	,
cord-015021-pol2qm74	2785	27	and	and	CC
cord-015021-pol2qm74	2785	28	effector	effector	NN
cord-015021-pol2qm74	2785	29	cells	cell	NNS
cord-015021-pol2qm74	2785	30	of	of	IN
cord-015021-pol2qm74	2785	31	adaptiye	adaptiye	JJ
cord-015021-pol2qm74	2785	32	resistance	resistance	NN
cord-015021-pol2qm74	2785	33	,	,	,
cord-015021-pol2qm74	2785	34	T	T	NNP
cord-015021-pol2qm74	2785	35	and	and	CC
cord-015021-pol2qm74	2785	36	B	b	NN
cord-015021-pol2qm74	2785	37	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2785	38	.	.	.
cord-015021-pol2qm74	2786	1	The	the	DT
cord-015021-pol2qm74	2786	2	ability	ability	NN
cord-015021-pol2qm74	2786	3	of	of	IN
cord-015021-pol2qm74	2786	4	IL-12	IL-12	NNP
cord-015021-pol2qm74	2786	5	to	to	TO
cord-015021-pol2qm74	2786	6	induce	induce	VB
cord-015021-pol2qm74	2786	7	IFN	IFN	NNP
cord-015021-pol2qm74	2786	8	-	-	HYPH
cord-015021-pol2qm74	2786	9	y	y	NNP
cord-015021-pol2qm74	2786	10	production	production	NN
cord-015021-pol2qm74	2786	11	from	from	IN
cord-015021-pol2qm74	2786	12	circulating	circulate	VBG
cord-015021-pol2qm74	2786	13	.	.	.
cord-015021-pol2qm74	2787	1	NK	NK	NNP
cord-015021-pol2qm74	2787	2	cells	cell	NNS
cord-015021-pol2qm74	2787	3	and	and	CC
cord-015021-pol2qm74	2787	4	at	at	IN
cord-015021-pol2qm74	2787	5	least	least	JJS
cord-015021-pol2qm74	2787	6	a	a	DT
cord-015021-pol2qm74	2787	7	proportion	proportion	NN
cord-015021-pol2qm74	2787	8	of	of	IN
cord-015021-pol2qm74	2787	9	T	t	NN
cord-015021-pol2qm74	2787	10	cells	cell	NNS
cord-015021-pol2qm74	2787	11	determines	determine	VBZ
cord-015021-pol2qm74	2787	12	a	a	DT
cord-015021-pol2qm74	2787	13	rapid	rapid	JJ
cord-015021-pol2qm74	2787	14	,	,	,
cord-015021-pol2qm74	2787	15	antigen	antigen	NN
cord-015021-pol2qm74	2787	16	-	-	HYPH
cord-015021-pol2qm74	2787	17	independet	independet	JJ
cord-015021-pol2qm74	2787	18	production	production	NN
cord-015021-pol2qm74	2787	19	of	of	IN
cord-015021-pol2qm74	2787	20	IFN	IFN	NNP
cord-015021-pol2qm74	2787	21	-	-	HYPH
cord-015021-pol2qm74	2787	22	y	y	NNP
cord-015021-pol2qm74	2787	23	during	during	IN
cord-015021-pol2qm74	2787	24	infections	infection	NNS
cord-015021-pol2qm74	2787	25	.	.	.
cord-015021-pol2qm74	2788	1	IFN	IFN	NNP
cord-015021-pol2qm74	2788	2	-	-	HYPH
cord-015021-pol2qm74	2788	3	y	y	NNP
cord-015021-pol2qm74	2788	4	acts	act	VBZ
cord-015021-pol2qm74	2788	5	as	as	IN
cord-015021-pol2qm74	2788	6	a	a	DT
cord-015021-pol2qm74	2788	7	potent	potent	JJ
cord-015021-pol2qm74	2788	8	enhancer	enhancer	NN
cord-015021-pol2qm74	2788	9	of	of	IN
cord-015021-pol2qm74	2788	10	phagocytic	phagocytic	NN
cord-015021-pol2qm74	2788	11	and	and	CC
cord-015021-pol2qm74	2788	12	bacteriocidal	bacteriocidal	JJ
cord-015021-pol2qm74	2788	13	activity	activity	NN
cord-015021-pol2qm74	2788	14	of	of	IN
cord-015021-pol2qm74	2788	15	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2788	16	cells	cell	NNS
cord-015021-pol2qm74	2788	17	,	,	,
cord-015021-pol2qm74	2788	18	participating	participate	VBG
cord-015021-pol2qm74	2788	19	early	early	RB
cord-015021-pol2qm74	2788	20	in	in	IN
cord-015021-pol2qm74	2788	21	infection	infection	NN
cord-015021-pol2qm74	2788	22	to	to	TO
cord-015021-pol2qm74	2788	23	activate	activate	VB
cord-015021-pol2qm74	2788	24	some	some	DT
cord-015021-pol2qm74	2788	25	of	of	IN
cord-015021-pol2qm74	2788	26	the	the	DT
cord-015021-pol2qm74	2788	27	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2788	28	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2788	29	that	that	WDT
cord-015021-pol2qm74	2788	30	represent	represent	VBP
cord-015021-pol2qm74	2788	31	the	the	DT
cord-015021-pol2qm74	2788	32	first	first	JJ
cord-015021-pol2qm74	2788	33	innate	innate	JJ
cord-015021-pol2qm74	2788	34	resistance	resistance	NN
cord-015021-pol2qm74	2788	35	against	against	IN
cord-015021-pol2qm74	2788	36	infection	infection	NN
cord-015021-pol2qm74	2788	37	.	.	.
cord-015021-pol2qm74	2789	1	This	this	DT
cord-015021-pol2qm74	2789	2	antigem	antigem	NNS
cord-015021-pol2qm74	2789	3	-	-	HYPH
cord-015021-pol2qm74	2789	4	independet	independet	JJ
cord-015021-pol2qm74	2789	5	activation	activation	NN
cord-015021-pol2qm74	2789	6	of	of	IN
cord-015021-pol2qm74	2789	7	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2789	8	cells	cell	NNS
cord-015021-pol2qm74	2789	9	that	that	WDT
cord-015021-pol2qm74	2789	10	involves	involve	VBZ
cord-015021-pol2qm74	2789	11	,	,	,
cord-015021-pol2qm74	2789	12	in	in	IN
cord-015021-pol2qm74	2789	13	addition	addition	NN
cord-015021-pol2qm74	2789	14	to	to	IN
cord-015021-pol2qm74	2789	15	IL-12	IL-12	NNP
cord-015021-pol2qm74	2789	16	,	,	,
cord-015021-pol2qm74	2789	17	other	other	JJ
cord-015021-pol2qm74	2789	18	monocyte	monocyte	NNP
cord-015021-pol2qm74	2789	19	derived	derive	VBD
cord-015021-pol2qm74	2789	20	cytokines	cytokine	NNS
cord-015021-pol2qm74	2789	21	such	such	JJ
cord-015021-pol2qm74	2789	22	as	as	IN
cord-015021-pol2qm74	2789	23	TNF	TNF	NNP
cord-015021-pol2qm74	2789	24	and	and	CC
cord-015021-pol2qm74	2789	25	IL	IL	NNP
cord-015021-pol2qm74	2789	26	-	-	HYPH
cord-015021-pol2qm74	2789	27	l	l	NNP
cord-015021-pol2qm74	2789	28	,	,	,
cord-015021-pol2qm74	2789	29	has	have	VBZ
cord-015021-pol2qm74	2789	30	been	be	VBN
cord-015021-pol2qm74	2789	31	shown	show	VBN
cord-015021-pol2qm74	2789	32	to	to	TO
cord-015021-pol2qm74	2789	33	be	be	VB
cord-015021-pol2qm74	2789	34	important	important	JJ
cord-015021-pol2qm74	2789	35	in	in	IN
cord-015021-pol2qm74	2789	36	experimental	experimental	JJ
cord-015021-pol2qm74	2789	37	animals	animal	NNS
cord-015021-pol2qm74	2789	38	for	for	IN
cord-015021-pol2qm74	2789	39	the	the	DT
cord-015021-pol2qm74	2789	40	resistance	resistance	NN
cord-015021-pol2qm74	2789	41	against	against	IN
cord-015021-pol2qm74	2789	42	infection	infection	NN
cord-015021-pol2qm74	2789	43	by	by	IN
cord-015021-pol2qm74	2789	44	microorganisms	microorganism	NNS
cord-015021-pol2qm74	2789	45	such	such	JJ
cord-015021-pol2qm74	2789	46	as	as	IN
cord-015021-pol2qm74	2789	47	Limteria	Limteria	NNP
cord-015021-pol2qm74	2789	48	monocytogens	monocytogens	NN
cord-015021-pol2qm74	2789	49	and	and	CC
cord-015021-pol2qm74	2789	50	Toxoplasma	toxoplasma	NN
cord-015021-pol2qm74	2789	51	gondii	gondii	NN
cord-015021-pol2qm74	2789	52	.	.	.
cord-015021-pol2qm74	2790	1	In	in	IN
cord-015021-pol2qm74	2790	2	addition	addition	NN
cord-015021-pol2qm74	2790	3	to	to	IN
cord-015021-pol2qm74	2790	4	this	this	DT
cord-015021-pol2qm74	2790	5	role	role	NN
cord-015021-pol2qm74	2790	6	,	,	,
cord-015021-pol2qm74	2790	7	early	early	RB
cord-015021-pol2qm74	2790	8	in	in	IN
cord-015021-pol2qm74	2790	9	infection	infection	NN
cord-015021-pol2qm74	2790	10	in	in	IN
cord-015021-pol2qm74	2790	11	the	the	DT
cord-015021-pol2qm74	2790	12	antigen	antigen	NN
cord-015021-pol2qm74	2790	13	-	-	HYPH
cord-015021-pol2qm74	2790	14	independet	independet	JJ
cord-015021-pol2qm74	2790	15	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2790	16	cell	cell	NN
cord-015021-pol2qm74	2790	17	activation	activation	NN
cord-015021-pol2qm74	2790	18	,	,	,
cord-015021-pol2qm74	2790	19	IL-12	IL-12	NNP
cord-015021-pol2qm74	2790	20	has	have	VBZ
cord-015021-pol2qm74	2790	21	a	a	DT
cord-015021-pol2qm74	2790	22	major	major	JJ
cord-015021-pol2qm74	2790	23	effect	effect	NN
cord-015021-pol2qm74	2790	24	in	in	IN
cord-015021-pol2qm74	2790	25	the	the	DT
cord-015021-pol2qm74	2790	26	ensuing	ensue	VBG
cord-015021-pol2qm74	2790	27	antigenspecific	antigenspecific	NNP
cord-015021-pol2qm74	2790	28	admptive	admptive	NNP
cord-015021-pol2qm74	2790	29	immune	immune	JJ
cord-015021-pol2qm74	2790	30	response	response	NN
cord-015021-pol2qm74	2790	31	by	by	IN
cord-015021-pol2qm74	2790	32	facilitating	facilitate	VBG
cord-015021-pol2qm74	2790	33	the	the	DT
cord-015021-pol2qm74	2790	34	generation	generation	NN
cord-015021-pol2qm74	2790	35	of	of	IN
cord-015021-pol2qm74	2790	36	T	T	NNP
cord-015021-pol2qm74	2790	37	helper	helper	NN
cord-015021-pol2qm74	2790	38	type	type	NN
cord-015021-pol2qm74	2790	39	1	1	CD
cord-015021-pol2qm74	2790	40	(	(	-LRB-
cord-015021-pol2qm74	2790	41	TH	TH	NNP
cord-015021-pol2qm74	2790	42	-	-	HYPH
cord-015021-pol2qm74	2790	43	I	i	NN
cord-015021-pol2qm74	2790	44	)	)	-RRB-
cord-015021-pol2qm74	2790	45	response	response	NN
cord-015021-pol2qm74	2790	46	and	and	CC
cord-015021-pol2qm74	2790	47	suppressing	suppress	VBG
cord-015021-pol2qm74	2790	48	a	a	DT
cord-015021-pol2qm74	2790	49	Th-2	Th-2	NNP
cord-015021-pol2qm74	2790	50	response	response	NN
cord-015021-pol2qm74	2790	51	.	.	.
cord-015021-pol2qm74	2791	1	The	the	DT
cord-015021-pol2qm74	2791	2	presence	presence	NN
cord-015021-pol2qm74	2791	3	of	of	IN
cord-015021-pol2qm74	2791	4	IL-12	IL-12	NNP
cord-015021-pol2qm74	2791	5	during	during	IN
cord-015021-pol2qm74	2791	6	antigen	antigen	NN
cord-015021-pol2qm74	2791	7	stimulation	stimulation	NN
cord-015021-pol2qm74	2791	8	in	in	IN
cord-015021-pol2qm74	2791	9	vitro	vitro	FW
cord-015021-pol2qm74	2791	10	using	use	VBG
cord-015021-pol2qm74	2791	11	human	human	JJ
cord-015021-pol2qm74	2791	12	peripheral	peripheral	JJ
cord-015021-pol2qm74	2791	13	blood	blood	NN
cord-015021-pol2qm74	2791	14	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2791	15	,	,	,
cord-015021-pol2qm74	2791	16	or	or	CC
cord-015021-pol2qm74	2791	17	both	both	CC
cord-015021-pol2qm74	2791	18	in	in	IN
cord-015021-pol2qm74	2791	19	vivo	vivo	NN
cord-015021-pol2qm74	2791	20	and	and	CC
cord-015021-pol2qm74	2791	21	in	in	IN
cord-015021-pol2qm74	2791	22	vitro	vitro	FW
cord-015021-pol2qm74	2791	23	in	in	IN
cord-015021-pol2qm74	2791	24	experimental	experimental	JJ
cord-015021-pol2qm74	2791	25	animals	animal	NNS
cord-015021-pol2qm74	2791	26	,	,	,
cord-015021-pol2qm74	2791	27	induces	induce	VBZ
cord-015021-pol2qm74	2791	28	generation	generation	NN
cord-015021-pol2qm74	2791	29	of	of	IN
cord-015021-pol2qm74	2791	30	Th	Th	NNP
cord-015021-pol2qm74	2791	31	-	-	HYPH
cord-015021-pol2qm74	2791	32	i	i	PRP
cord-015021-pol2qm74	2791	33	cells	cell	NNS
cord-015021-pol2qm74	2791	34	producing	produce	VBG
cord-015021-pol2qm74	2791	35	IFN	IFN	NNP
cord-015021-pol2qm74	2791	36	-	-	HYPH
cord-015021-pol2qm74	2791	37	y	y	NNP
cord-015021-pol2qm74	2791	38	and	and	CC
cord-015021-pol2qm74	2791	39	IL-2	IL-2	NNP
cord-015021-pol2qm74	2791	40	,	,	,
cord-015021-pol2qm74	2791	41	and	and	CC
cord-015021-pol2qm74	2791	42	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2791	43	the	the	DT
cord-015021-pol2qm74	2791	44	generation	generation	NN
cord-015021-pol2qm74	2791	45	of	of	IN
cord-015021-pol2qm74	2791	46	Th-2	Th-2	NNP
cord-015021-pol2qm74	2791	47	cells	cell	NNS
cord-015021-pol2qm74	2791	48	producing	produce	VBG
cord-015021-pol2qm74	2791	49	IL-4	IL-4	NNP
cord-015021-pol2qm74	2791	50	.	.	.
cord-015021-pol2qm74	2791	51	IL-12	IL-12	NNP
cord-015021-pol2qm74	2791	52	induces	induce	VBZ
cord-015021-pol2qm74	2791	53	a	a	DT
cord-015021-pol2qm74	2791	54	direct	direct	JJ
cord-015021-pol2qm74	2791	55	differentiative	differentiative	JJ
cord-015021-pol2qm74	2791	56	effect	effect	NN
cord-015021-pol2qm74	2791	57	on	on	IN
cord-015021-pol2qm74	2791	58	Th	Th	NNP
cord-015021-pol2qm74	2791	59	-	-	HYPH
cord-015021-pol2qm74	2791	60	cells	cell	NNS
cord-015021-pol2qm74	2791	61	,	,	,
cord-015021-pol2qm74	2791	62	priming	prime	VBG
cord-015021-pol2qm74	2791	63	them	-PRON-	PRP
cord-015021-pol2qm74	2791	64	for	for	IN
cord-015021-pol2qm74	2791	65	high	high	JJ
cord-015021-pol2qm74	2791	66	IFN	IFN	NNP
cord-015021-pol2qm74	2791	67	-	-	HYPH
cord-015021-pol2qm74	2791	68	y	y	NNP
cord-015021-pol2qm74	2791	69	production	production	NN
cord-015021-pol2qm74	2791	70	.	.	.
cord-015021-pol2qm74	2792	1	~is	~is	NFP
cord-015021-pol2qm74	2792	2	priming	prime	VBG
cord-015021-pol2qm74	2792	3	effect	effect	NN
cord-015021-pol2qm74	2792	4	is	be	VBZ
cord-015021-pol2qm74	2792	5	stable	stable	JJ
cord-015021-pol2qm74	2792	6	and	and	CC
cord-015021-pol2qm74	2792	7	maintained	maintain	VBD
cord-015021-pol2qm74	2792	8	even	even	RB
cord-015021-pol2qm74	2792	9	when	when	WRB
cord-015021-pol2qm74	2792	10	T	T	NNP
cord-015021-pol2qm74	2792	11	cell	cell	NN
cord-015021-pol2qm74	2792	12	clones	clone	NNS
cord-015021-pol2qm74	2792	13	are	be	VBP
cord-015021-pol2qm74	2792	14	cultured	culture	VBN
cord-015021-pol2qm74	2792	15	for	for	IN
cord-015021-pol2qm74	2792	16	extended	extended	JJ
cord-015021-pol2qm74	2792	17	periods	period	NNS
cord-015021-pol2qm74	2792	18	in	in	IN
cord-015021-pol2qm74	2792	19	the	the	DT
cord-015021-pol2qm74	2792	20	absence	absence	NN
cord-015021-pol2qm74	2792	21	of	of	IN
cord-015021-pol2qm74	2792	22	IL-12	IL-12	NNP
cord-015021-pol2qm74	2792	23	,	,	,
cord-015021-pol2qm74	2792	24	however	however	RB
cord-015021-pol2qm74	2792	25	,	,	,
cord-015021-pol2qm74	2792	26	IL-12	IL-12	NNP
cord-015021-pol2qm74	2792	27	needs	need	VBZ
cord-015021-pol2qm74	2792	28	to	to	TO
cord-015021-pol2qm74	2792	29	be	be	VB
cord-015021-pol2qm74	2792	30	present	present	JJ
cord-015021-pol2qm74	2792	31	during	during	IN
cord-015021-pol2qm74	2792	32	the	the	DT
cord-015021-pol2qm74	2792	33	first	first	JJ
cord-015021-pol2qm74	2792	34	few	few	JJ
cord-015021-pol2qm74	2792	35	days	day	NNS
cord-015021-pol2qm74	2792	36	after	after	IN
cord-015021-pol2qm74	2792	37	stimulation	stimulation	NN
cord-015021-pol2qm74	2792	38	with	with	IN
cord-015021-pol2qm74	2792	39	antigen	antigen	NN
cord-015021-pol2qm74	2792	40	or	or	CC
cord-015021-pol2qm74	2792	41	mitogen	mitogen	NNP
cord-015021-pol2qm74	2792	42	and	and	CC
cord-015021-pol2qm74	2792	43	established	establish	VBD
cord-015021-pol2qm74	2792	44	Th	Th	NNP
cord-015021-pol2qm74	2792	45	clones	clone	NNS
cord-015021-pol2qm74	2792	46	are	be	VBP
cord-015021-pol2qm74	2792	47	resistant	resistant	JJ
cord-015021-pol2qm74	2792	48	to	to	IN
cord-015021-pol2qm74	2792	49	the	the	DT
cord-015021-pol2qm74	2792	50	priming	priming	NN
cord-015021-pol2qm74	2792	51	effect	effect	NN
cord-015021-pol2qm74	2792	52	of	of	IN
cord-015021-pol2qm74	2792	53	IFN	IFN	NNP
cord-015021-pol2qm74	2792	54	-	-	HYPH
cord-015021-pol2qm74	2792	55	y	y	NNP
cord-015021-pol2qm74	2792	56	.	.	.
cord-015021-pol2qm74	2793	1	Unlike	unlike	IN
cord-015021-pol2qm74	2793	2	the	the	DT
cord-015021-pol2qm74	2793	3	generation	generation	NN
cord-015021-pol2qm74	2793	4	of	of	IN
cord-015021-pol2qm74	2793	5	high	high	JJ
cord-015021-pol2qm74	2793	6	IFN	IFN	NNP
cord-015021-pol2qm74	2793	7	-	-	HYPH
cord-015021-pol2qm74	2793	8	y	y	NNP
cord-015021-pol2qm74	2793	9	producing	produce	VBG
cord-015021-pol2qm74	2793	10	clones	clone	NNS
cord-015021-pol2qm74	2793	11	,	,	,
cord-015021-pol2qm74	2793	12	the	the	DT
cord-015021-pol2qm74	2793	13	IL-12-mediated	il-12-mediated	JJ
cord-015021-pol2qm74	2793	14	inhibition	inhibition	NN
cord-015021-pol2qm74	2793	15	of	of	IN
cord-015021-pol2qm74	2793	16	IL-4	IL-4	NNP
cord-015021-pol2qm74	2793	17	producing	produce	VBG
cord-015021-pol2qm74	2793	18	cells	cell	NNS
cord-015021-pol2qm74	2793	19	in	in	IN
cord-015021-pol2qm74	2793	20	probably	probably	RB
cord-015021-pol2qm74	2793	21	due	due	JJ
cord-015021-pol2qm74	2793	22	to	to	IN
cord-015021-pol2qm74	2793	23	selective	selective	JJ
cord-015021-pol2qm74	2793	24	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2793	25	,	,	,
cord-015021-pol2qm74	2793	26	which	which	WDT
cord-015021-pol2qm74	2793	27	may	may	MD
cord-015021-pol2qm74	2793	28	include	include	VB
cord-015021-pol2qm74	2793	29	a	a	DT
cord-015021-pol2qm74	2793	30	selective	selective	JJ
cord-015021-pol2qm74	2793	31	mitegenic	mitegenic	JJ
cord-015021-pol2qm74	2793	32	effect	effect	NN
cord-015021-pol2qm74	2793	33	of	of	IN
cord-015021-pol2qm74	2793	34	IL-12	IL-12	NNP
cord-015021-pol2qm74	2793	35	for	for	IN
cord-015021-pol2qm74	2793	36	Thl	Thl	NNP
cord-015021-pol2qm74	2793	37	cells	cell	NNS
cord-015021-pol2qm74	2793	38	and	and	CC
cord-015021-pol2qm74	2793	39	an	an	DT
cord-015021-pol2qm74	2793	40	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	2793	41	effect	effect	NN
cord-015021-pol2qm74	2793	42	of	of	IN
cord-015021-pol2qm74	2793	43	IFN	IFN	NNP
cord-015021-pol2qm74	2793	44	-	-	HYPH
cord-015021-pol2qm74	2793	45	y	y	NNP
cord-015021-pol2qm74	2793	46	on	on	IN
cord-015021-pol2qm74	2793	47	Th2	Th2	NNP
cord-015021-pol2qm74	2793	48	cell	cell	NN
cord-015021-pol2qm74	2793	49	proliferation	proliferation	NN
cord-015021-pol2qm74	2793	50	.	.	.
cord-015021-pol2qm74	2794	1	In	in	IN
cord-015021-pol2qm74	2794	2	several	several	JJ
cord-015021-pol2qm74	2794	3	experimental	experimental	JJ
cord-015021-pol2qm74	2794	4	systems	system	NNS
cord-015021-pol2qm74	2794	5	,	,	,
cord-015021-pol2qm74	2794	6	it	-PRON-	PRP
cord-015021-pol2qm74	2794	7	has	have	VBZ
cord-015021-pol2qm74	2794	8	been	be	VBN
cord-015021-pol2qm74	2794	9	shown	show	VBN
cord-015021-pol2qm74	2794	10	that	that	IN
cord-015021-pol2qm74	2794	11	the	the	DT
cord-015021-pol2qm74	2794	12	enhancing	enhance	VBG
cord-015021-pol2qm74	2794	13	effect	effect	NN
cord-015021-pol2qm74	2794	14	of	of	IN
cord-015021-pol2qm74	2794	15	IL-12	IL-12	NNP
cord-015021-pol2qm74	2794	16	on	on	IN
cord-015021-pol2qm74	2794	17	Th	Th	NNP
cord-015021-pol2qm74	2794	18	-	-	HYPH
cord-015021-pol2qm74	2794	19	i	i	PRP
cord-015021-pol2qm74	2794	20	responses	response	NNS
cord-015021-pol2qm74	2794	21	is	be	VBZ
cord-015021-pol2qm74	2794	22	dependent	dependent	JJ
cord-015021-pol2qm74	2794	23	on	on	IN
cord-015021-pol2qm74	2794	24	production	production	NN
cord-015021-pol2qm74	2794	25	of	of	IN
cord-015021-pol2qm74	2794	26	IF~-y	IF~-y	NNP
cord-015021-pol2qm74	2794	27	and	and	CC
cord-015021-pol2qm74	2794	28	on	on	IN
cord-015021-pol2qm74	2794	29	the	the	DT
cord-015021-pol2qm74	2794	30	presence	presence	NN
cord-015021-pol2qm74	2794	31	of	of	IN
cord-015021-pol2qm74	2794	32	NK	NK	NNP
cord-015021-pol2qm74	2794	33	cells	cell	NNS
cord-015021-pol2qm74	2794	34	,	,	,
cord-015021-pol2qm74	2794	35	possibly	possibly	RB
cord-015021-pol2qm74	2794	36	needed	need	VBN
cord-015021-pol2qm74	2794	37	for	for	IN
cord-015021-pol2qm74	2794	38	the	the	DT
cord-015021-pol2qm74	2794	39	early	early	JJ
cord-015021-pol2qm74	2794	40	production	production	NN
cord-015021-pol2qm74	2794	41	of	of	IN
cord-015021-pol2qm74	2794	42	IFN	IFN	NNP
cord-015021-pol2qm74	2794	43	-	-	HYPH
cord-015021-pol2qm74	2794	44	y	y	NNP
cord-015021-pol2qm74	2794	45	.	.	.
cord-015021-pol2qm74	2795	1	The	the	DT
cord-015021-pol2qm74	2795	2	importance	importance	NN
cord-015021-pol2qm74	2795	3	of	of	IN
cord-015021-pol2qm74	2795	4	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2795	5	cells	cell	NNS
cord-015021-pol2qm74	2795	6	and	and	CC
cord-015021-pol2qm74	2795	7	NK	NK	NNP
cord-015021-pol2qm74	2795	8	cells	cell	NNS
cord-015021-pol2qm74	2795	9	in	in	IN
cord-015021-pol2qm74	2795	10	determining	determine	VBG
cord-015021-pol2qm74	2795	11	the	the	DT
cord-015021-pol2qm74	2795	12	characteristics	characteristic	NNS
cord-015021-pol2qm74	2795	13	of	of	IN
cord-015021-pol2qm74	2795	14	the	the	DT
cord-015021-pol2qm74	2795	15	Th	Th	NNP
cord-015021-pol2qm74	2795	16	response	response	NN
cord-015021-pol2qm74	2795	17	during	during	IN
cord-015021-pol2qm74	2795	18	antigenic	antigenic	JJ
cord-015021-pol2qm74	2795	19	stimulation	stimulation	NN
cord-015021-pol2qm74	2795	20	indicated	indicate	VBD
cord-015021-pol2qm74	2795	21	that	that	IN
cord-015021-pol2qm74	2795	22	the	the	DT
cord-015021-pol2qm74	2795	23	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2795	24	of	of	IN
cord-015021-pol2qm74	2795	25	innate	innate	JJ
cord-015021-pol2qm74	2795	26	resistance	resistance	NN
cord-015021-pol2qm74	2795	27	have	have	VBP
cord-015021-pol2qm74	2795	28	a	a	DT
cord-015021-pol2qm74	2795	29	determining	determine	VBG
cord-015021-pol2qm74	2795	30	influence	influence	NN
cord-015021-pol2qm74	2795	31	on	on	IN
cord-015021-pol2qm74	2795	32	the	the	DT
cord-015021-pol2qm74	2795	33	subsequent	subsequent	JJ
cord-015021-pol2qm74	2795	34	antigen	antigen	NN
cord-015021-pol2qm74	2795	35	-	-	HYPH
cord-015021-pol2qm74	2795	36	specific	specific	JJ
cord-015021-pol2qm74	2795	37	immune	immune	JJ
cord-015021-pol2qm74	2795	38	response	response	NN
cord-015021-pol2qm74	2795	39	:	:	:
cord-015021-pol2qm74	2795	40	IL-12	IL-12	NNP
cord-015021-pol2qm74	2795	41	appears	appear	VBZ
cord-015021-pol2qm74	2795	42	to	to	TO
cord-015021-pol2qm74	2795	43	have	have	VB
cord-015021-pol2qm74	2795	44	a	a	DT
cord-015021-pol2qm74	2795	45	key	key	JJ
cord-015021-pol2qm74	2795	46	role	role	NN
cord-015021-pol2qm74	2795	47	in	in	IN
cord-015021-pol2qm74	2795	48	mediating	mediate	VBG
cord-015021-pol2qm74	2795	49	the	the	DT
cord-015021-pol2qm74	2795	50	interaction	interaction	NN
cord-015021-pol2qm74	2795	51	between	between	IN
cord-015021-pol2qm74	2795	52	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	2795	53	cells	cell	NNS
cord-015021-pol2qm74	2795	54	.	.	.
cord-015021-pol2qm74	2796	1	NK	NK	NNP
cord-015021-pol2qm74	2796	2	cells	cell	NNS
cord-015021-pol2qm74	2796	3	,	,	,
cord-015021-pol2qm74	2796	4	and	and	CC
cord-015021-pol2qm74	2796	5	T	T	NNP
cord-015021-pol2qm74	2796	6	lympocytes	lympocyte	NNS
cord-015021-pol2qm74	2796	7	in	in	IN
cord-015021-pol2qm74	2796	8	these	these	DT
cord-015021-pol2qm74	2796	9	proccessem	proccessem	NN
cord-015021-pol2qm74	2796	10	.	.	.
cord-015021-pol2qm74	2797	1	Trinchieri	Trinchieri	NNP
cord-015021-pol2qm74	2797	2	,	,	,
cord-015021-pol2qm74	2797	3	G.	G.	NNP
cord-015021-pol2qm74	2797	4	1993	1993	CD
cord-015021-pol2qm74	2797	5	,	,	,
cord-015021-pol2qm74	2797	6	Interleukin-12	Interleukin-12	NNP
cord-015021-pol2qm74	2797	7	and	and	CC
cord-015021-pol2qm74	2797	8	its	-PRON-	PRP$
cord-015021-pol2qm74	2797	9	role	role	NN
cord-015021-pol2qm74	2797	10	in	in	IN
cord-015021-pol2qm74	2797	11	the	the	DT
cord-015021-pol2qm74	2797	12	generation	generation	NN
cord-015021-pol2qm74	2797	13	of	of	IN
cord-015021-pol2qm74	2797	14	T	t	NN
cord-015021-pol2qm74	2797	15	E	e	NN
cord-015021-pol2qm74	2797	16	1	1	CD
cord-015021-pol2qm74	2797	17	cells	cell	NNS
cord-015021-pol2qm74	2797	18	,	,	,
cord-015021-pol2qm74	2797	19	Imm	Imm	NNP
cord-015021-pol2qm74	2797	20	~	~	NFP
cord-015021-pol2qm74	2797	21	ol	ol	UH
cord-015021-pol2qm74	2797	22	.	.	.
cord-015021-pol2qm74	2798	1	On	on	IN
cord-015021-pol2qm74	2798	2	peripheral	peripheral	JJ
cord-015021-pol2qm74	2798	3	blood	blood	NN
cord-015021-pol2qm74	2798	4	monocyte	monocyte	NNP
cord-015021-pol2qm74	2798	5	/	/	SYM
cord-015021-pol2qm74	2798	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	2798	7	,	,	,
cord-015021-pol2qm74	2798	8	IL-13	IL-13	NNP
cord-015021-pol2qm74	2798	9	behaves	behave	VBZ
cord-015021-pol2qm74	2798	10	like	like	IN
cord-015021-pol2qm74	2798	11	IL-4	IL-4	NNP
cord-015021-pol2qm74	2798	12	in	in	IN
cord-015021-pol2qm74	2798	13	a	a	DT
cord-015021-pol2qm74	2798	14	variety	variety	NN
cord-015021-pol2qm74	2798	15	of	of	IN
cord-015021-pol2qm74	2798	16	assays	assay	NNS
cord-015021-pol2qm74	2798	17	,	,	,
cord-015021-pol2qm74	2798	18	and	and	CC
cord-015021-pol2qm74	2798	19	shows	show	VBZ
cord-015021-pol2qm74	2798	20	both	both	CC
cord-015021-pol2qm74	2798	21	similar	similar	JJ
cord-015021-pol2qm74	2798	22	and	and	CC
cord-015021-pol2qm74	2798	23	contrasting	contrasting	JJ
cord-015021-pol2qm74	2798	24	,	,	,
cord-015021-pol2qm74	2798	25	activties	activtie	NNS
cord-015021-pol2qm74	2798	26	with	with	IN
cord-015021-pol2qm74	2798	27	either	either	CC
cord-015021-pol2qm74	2798	28	IL-10	IL-10	NNP
cord-015021-pol2qm74	2798	29	or	or	CC
cord-015021-pol2qm74	2798	30	IFN	IFN	NNP
cord-015021-pol2qm74	2798	31	-	-	HYPH
cord-015021-pol2qm74	2798	32	y	y	NNP
cord-015021-pol2qm74	2798	33	.	.	.
cord-015021-pol2qm74	2799	1	IL-13	IL-13	NNP
cord-015021-pol2qm74	2799	2	reduces	reduce	VBZ
cord-015021-pol2qm74	2799	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2799	4	monokine	monokine	NN
cord-015021-pol2qm74	2799	5	and	and	CC
cord-015021-pol2qm74	2799	6	IL-10	IL-10	NNP
cord-015021-pol2qm74	2799	7	production	production	NN
cord-015021-pol2qm74	2799	8	.	.	.
cord-015021-pol2qm74	2800	1	It	-PRON-	PRP
cord-015021-pol2qm74	2800	2	reduces	reduce	VBZ
cord-015021-pol2qm74	2800	3	the	the	DT
cord-015021-pol2qm74	2800	4	pyrogen	pyrogen	NN
cord-015021-pol2qm74	2800	5	-	-	HYPH
cord-015021-pol2qm74	2800	6	induced	induce	VBN
cord-015021-pol2qm74	2800	7	expression	expression	NN
cord-015021-pol2qm74	2800	8	of	of	IN
cord-015021-pol2qm74	2800	9	tissue	tissue	NN
cord-015021-pol2qm74	2800	10	factor	factor	NN
cord-015021-pol2qm74	2801	1	(	(	-LRB-
cord-015021-pol2qm74	2801	2	Herbert	Herbert	NNP
cord-015021-pol2qm74	2801	3	et	et	NNP
cord-015021-pol2qm74	2801	4	el	el	NNP
cord-015021-pol2qm74	2801	5	,	,	,
cord-015021-pol2qm74	2801	6	1993	1993	CD
cord-015021-pol2qm74	2801	7	,	,	,
cord-015021-pol2qm74	2801	8	FEBS	FEBS	NNP
cord-015021-pol2qm74	2801	9	Lett	Lett	NNP
cord-015021-pol2qm74	2801	10	.	.	.
cord-015021-pol2qm74	2802	1	328	328	CD
cord-015021-pol2qm74	2802	2	,	,	,
cord-015021-pol2qm74	2802	3	268	268	CD
cord-015021-pol2qm74	2802	4	)	)	-RRB-
cord-015021-pol2qm74	2802	5	.	.	.
cord-015021-pol2qm74	2803	1	It	-PRON-	PRP
cord-015021-pol2qm74	2803	2	mpregulates	mpregulate	VBZ
cord-015021-pol2qm74	2803	3	manmose	manmose	JJ
cord-015021-pol2qm74	2803	4	receptor	receptor	NN
cord-015021-pol2qm74	2803	5	and	and	CC
cord-015021-pol2qm74	2803	6	~C	~C	NFP
cord-015021-pol2qm74	2803	7	class	class	NN
cord-015021-pol2qm74	2803	8	II	ii	CD
cord-015021-pol2qm74	2803	9	expression	expression	NN
cord-015021-pol2qm74	2803	10	,	,	,
cord-015021-pol2qm74	2803	11	while	while	IN
cord-015021-pol2qm74	2803	12	reducing	reduce	VBG
cord-015021-pol2qm74	2803	13	CDI4	CDI4	NNP
cord-015021-pol2qm74	2803	14	expression	expression	NN
cord-015021-pol2qm74	2803	15	.	.	.
cord-015021-pol2qm74	2804	1	IL-13	IL-13	NNP
cord-015021-pol2qm74	2804	2	produces	produce	VBZ
cord-015021-pol2qm74	2804	3	morphological	morphological	JJ
cord-015021-pol2qm74	2804	4	changes	change	NNS
cord-015021-pol2qm74	2804	5	(	(	-LRB-
cord-015021-pol2qm74	2804	6	extensive	extensive	JJ
cord-015021-pol2qm74	2804	7	cell	cell	NN
cord-015021-pol2qm74	2804	8	processes	process	NNS
cord-015021-pol2qm74	2804	9	,	,	,
cord-015021-pol2qm74	2804	10	aggregation	aggregation	NN
cord-015021-pol2qm74	2804	11	,	,	,
cord-015021-pol2qm74	2804	12	giant	giant	JJ
cord-015021-pol2qm74	2804	13	cell	cell	NN
cord-015021-pol2qm74	2804	14	formation	formation	NN
cord-015021-pol2qm74	2804	15	)	)	-RRB-
cord-015021-pol2qm74	2804	16	which	which	WDT
cord-015021-pol2qm74	2804	17	have	have	VBP
cord-015021-pol2qm74	2804	18	previously	previously	RB
cord-015021-pol2qm74	2804	19	been	be	VBN
cord-015021-pol2qm74	2804	20	observed	observe	VBN
cord-015021-pol2qm74	2804	21	with	with	IN
cord-015021-pol2qm74	2804	22	IL-4	IL-4	NNP
cord-015021-pol2qm74	2804	23	.	.	.
cord-015021-pol2qm74	2805	1	It	-PRON-	PRP
cord-015021-pol2qm74	2805	2	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2805	3	NIV	NIV	NNP
cord-015021-pol2qm74	2805	4	-	-	HYPH
cord-015021-pol2qm74	2805	5	I	i	NN
cord-015021-pol2qm74	2805	6	production	production	NN
cord-015021-pol2qm74	2805	7	(	(	-LRB-
cord-015021-pol2qm74	2805	8	Montaner	Montaner	NNP
cord-015021-pol2qm74	2805	9	et	et	FW
cord-015021-pol2qm74	2805	10	el	el	NNP
cord-015021-pol2qm74	2805	11	,	,	,
cord-015021-pol2qm74	2805	12	1993	1993	CD
cord-015021-pol2qm74	2805	13	,	,	,
cord-015021-pol2qm74	2805	14	I.	I.	NNP
cord-015021-pol2qm74	2805	15	Exp	Exp	NNP
cord-015021-pol2qm74	2805	16	.	.	.
cord-015021-pol2qm74	2806	1	Mad	mad	JJ
cord-015021-pol2qm74	2806	2	.	.	.
cord-015021-pol2qm74	2807	1	178	178	CD
cord-015021-pol2qm74	2807	2	,	,	,
cord-015021-pol2qm74	2807	3	743	743	CD
cord-015021-pol2qm74	2807	4	)	)	-RRB-
cord-015021-pol2qm74	2807	5	,	,	,
cord-015021-pol2qm74	2807	6	and	and	CC
cord-015021-pol2qm74	2807	7	interferes	interfere	VBZ
cord-015021-pol2qm74	2807	8	with	with	IN
cord-015021-pol2qm74	2807	9	HIV	HIV	NNP
cord-015021-pol2qm74	2807	10	-	-	HYPH
cord-015021-pol2qm74	2807	11	induced	induce	VBN
cord-015021-pol2qm74	2807	12	cell	cell	NN
cord-015021-pol2qm74	2807	13	fusion	fusion	NN
cord-015021-pol2qm74	2807	14	.	.	.
cord-015021-pol2qm74	2808	1	The	the	DT
cord-015021-pol2qm74	2808	2	activities	activity	NNS
cord-015021-pol2qm74	2808	3	of	of	IN
cord-015021-pol2qm74	2808	4	IL-13	IL-13	NNP
cord-015021-pol2qm74	2808	5	and	and	CC
cord-015021-pol2qm74	2808	6	IL-4	IL-4	NNP
cord-015021-pol2qm74	2808	7	differ	differ	VBP
cord-015021-pol2qm74	2808	8	on	on	IN
cord-015021-pol2qm74	2808	9	T	T	NNP
cord-015021-pol2qm74	2808	10	-	-	HYPH
cord-015021-pol2qm74	2808	11	ly•ocyte	ly•ocyte	NNP
cord-015021-pol2qm74	2808	12	and	and	CC
cord-015021-pol2qm74	2808	13	large	large	JJ
cord-015021-pol2qm74	2808	14	granular	granular	JJ
cord-015021-pol2qm74	2808	15	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	2808	16	population	population	NN
cord-015021-pol2qm74	2808	17	.	.	.
cord-015021-pol2qm74	2809	1	In	in	IN
cord-015021-pol2qm74	2809	2	particular	particular	JJ
cord-015021-pol2qm74	2809	3	IL-13	IL-13	NNP
cord-015021-pol2qm74	2809	4	does	do	VBZ
cord-015021-pol2qm74	2809	5	not	not	RB
cord-015021-pol2qm74	2809	6	exhibit	exhibit	VB
cord-015021-pol2qm74	2809	7	the	the	DT
cord-015021-pol2qm74	2809	8	suppressive	suppressive	JJ
cord-015021-pol2qm74	2809	9	effects	effect	NNS
cord-015021-pol2qm74	2809	10	of	of	IN
cord-015021-pol2qm74	2809	11	IL-4	IL-4	NNP
cord-015021-pol2qm74	2809	12	on	on	IN
cord-015021-pol2qm74	2809	13	THl	THl	NNP
cord-015021-pol2qm74	2809	14	-	-	HYPH
cord-015021-pol2qm74	2809	15	type	type	NN
cord-015021-pol2qm74	2809	16	-	-	HYPH
cord-015021-pol2qm74	2809	17	helper	helper	NN
cord-015021-pol2qm74	2809	18	functions	function	NNS
cord-015021-pol2qm74	2809	19	(	(	-LRB-
cord-015021-pol2qm74	2809	20	IFNy	IFNy	NNP
cord-015021-pol2qm74	2809	21	production	production	NN
cord-015021-pol2qm74	2809	22	)	)	-RRB-
cord-015021-pol2qm74	2809	23	and	and	CC
cord-015021-pol2qm74	2809	24	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	2809	25	functions	function	NNS
cord-015021-pol2qm74	2809	26	(	(	-LRB-
cord-015021-pol2qm74	2809	27	perforin	perforin	NNP
cord-015021-pol2qm74	2809	28	production	production	NN
cord-015021-pol2qm74	2809	29	)	)	-RRB-
cord-015021-pol2qm74	2809	30	.	.	.
cord-015021-pol2qm74	2810	1	Data	datum	NNS
cord-015021-pol2qm74	2810	2	will	will	MD
cord-015021-pol2qm74	2810	3	be	be	VB
cord-015021-pol2qm74	2810	4	presented	present	VBN
cord-015021-pol2qm74	2810	5	showing	show	VBG
cord-015021-pol2qm74	2810	6	that	that	IN
cord-015021-pol2qm74	2810	7	IL-4	IL-4	NNP
cord-015021-pol2qm74	2810	8	and	and	CC
cord-015021-pol2qm74	2810	9	IL	IL	NNP
cord-015021-pol2qm74	2810	10	-	-	HYPH
cord-015021-pol2qm74	2810	11	l3	l3	NNP
cord-015021-pol2qm74	2810	12	share	share	VBP
cord-015021-pol2qm74	2810	13	a	a	DT
cord-015021-pol2qm74	2810	14	common	common	JJ
cord-015021-pol2qm74	2810	15	receptor	receptor	NN
cord-015021-pol2qm74	2810	16	on	on	IN
cord-015021-pol2qm74	2810	17	a	a	DT
cord-015021-pol2qm74	2810	18	nu	nu	NN
cord-015021-pol2qm74	2810	19	~	~	NNP
cord-015021-pol2qm74	2810	20	er	er	UH
cord-015021-pol2qm74	2810	21	of	of	IN
cord-015021-pol2qm74	2810	22	cell	cell	NN
cord-015021-pol2qm74	2810	23	types	type	NNS
cord-015021-pol2qm74	2810	24	,	,	,
cord-015021-pol2qm74	2810	25	but	but	CC
cord-015021-pol2qm74	2810	26	not	not	RB
cord-015021-pol2qm74	2810	27	on	on	IN
cord-015021-pol2qm74	2810	28	T	T	NNP
cord-015021-pol2qm74	2810	29	-	-	HYPH
cord-015021-pol2qm74	2810	30	lympocytes	lympocytes	NNP
cord-015021-pol2qm74	2810	31	(	(	-LRB-
cord-015021-pol2qm74	2810	32	see	see	VB
cord-015021-pol2qm74	2810	33	also	also	RB
cord-015021-pol2qm74	2810	34	Zmrawski	Zmrawski	NNP
cord-015021-pol2qm74	2810	35	st	st	NNP
cord-015021-pol2qm74	2810	36	el	el	NNP
cord-015021-pol2qm74	2810	37	.	.	NNP
cord-015021-pol2qm74	2810	38	1993	1993	CD
cord-015021-pol2qm74	2810	39	,	,	,
cord-015021-pol2qm74	2810	40	EMBO	EMBO	NNP
cord-015021-pol2qm74	2810	41	J.7	J.7	NNP
cord-015021-pol2qm74	2810	42	.	.	.
cord-015021-pol2qm74	2811	1	2663	2663	CD
cord-015021-pol2qm74	2811	2	-	-	HYPH
cord-015021-pol2qm74	2811	3	2670	2670	CD
cord-015021-pol2qm74	2811	4	)	)	-RRB-
cord-015021-pol2qm74	2811	5	,	,	,
cord-015021-pol2qm74	2811	6	explaining	explain	VBG
cord-015021-pol2qm74	2811	7	both	both	CC
cord-015021-pol2qm74	2811	8	thai	thai	JJ
cord-015021-pol2qm74	2811	9	common	common	JJ
cord-015021-pol2qm74	2811	10	and	and	CC
cord-015021-pol2qm74	2811	11	divergent	divergent	JJ
cord-015021-pol2qm74	2811	12	activities	activity	NNS
cord-015021-pol2qm74	2811	13	.	.	.
cord-015021-pol2qm74	2812	1	The	the	DT
cord-015021-pol2qm74	2812	2	levels	level	NNS
cord-015021-pol2qm74	2812	3	of	of	IN
cord-015021-pol2qm74	2812	4	IL-13~A	il-13~a	NN
cord-015021-pol2qm74	2812	5	in	in	IN
cord-015021-pol2qm74	2812	6	activated	activate	VBN
cord-015021-pol2qm74	2812	7	peripheral	peripheral	JJ
cord-015021-pol2qm74	2812	8	blood	blood	NN
cord-015021-pol2qm74	2812	9	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2812	10	are	be	VBP
cord-015021-pol2qm74	2812	11	greater	great	JJR
cord-015021-pol2qm74	2812	12	than	than	IN
cord-015021-pol2qm74	2812	13	or	or	CC
cord-015021-pol2qm74	2812	14	equivalent	equivalent	JJ
cord-015021-pol2qm74	2812	15	to	to	IN
cord-015021-pol2qm74	2812	16	those	those	DT
cord-015021-pol2qm74	2812	17	of	of	IN
cord-015021-pol2qm74	2812	18	IL-4	IL-4	NNP
cord-015021-pol2qm74	2812	19	mP	mP	.
cord-015021-pol2qm74	2813	1	~JA	~JA	NFP
cord-015021-pol2qm74	2813	2	and	and	CC
cord-015021-pol2qm74	2813	3	the	the	DT
cord-015021-pol2qm74	2813	4	two	two	CD
cord-015021-pol2qm74	2813	5	ml{NAs	ml{nas	CD
cord-015021-pol2qm74	2813	6	are	be	VBP
cord-015021-pol2qm74	2813	7	expressed	express	VBN
cord-015021-pol2qm74	2813	8	by	by	IN
cord-015021-pol2qm74	2813	9	different	different	JJ
cord-015021-pol2qm74	2813	10	T	T	NNP
cord-015021-pol2qm74	2813	11	lympocyte	lympocyte	NNP
cord-015021-pol2qm74	2813	12	population	population	NN
cord-015021-pol2qm74	2813	13	:	:	:
cord-015021-pol2qm74	2813	14	in	in	IN
cord-015021-pol2qm74	2813	15	particular	particular	JJ
cord-015021-pol2qm74	2813	16	,	,	,
cord-015021-pol2qm74	2813	17	T8	T8	NNP
cord-015021-pol2qm74	2813	18	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	2813	19	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2813	20	express	express	VBP
cord-015021-pol2qm74	2813	21	markedly	markedly	RB
cord-015021-pol2qm74	2813	22	higher	high	JJR
cord-015021-pol2qm74	2813	23	levels	level	NNS
cord-015021-pol2qm74	2813	24	of	of	IN
cord-015021-pol2qm74	2813	25	IL-13~RNA	IL-13~RNA	NNPS
cord-015021-pol2qm74	2813	26	.	.	.
cord-015021-pol2qm74	2814	1	In	in	IN
cord-015021-pol2qm74	2814	2	vivo	vivo	NN
cord-015021-pol2qm74	2814	3	,	,	,
cord-015021-pol2qm74	2814	4	IL-13	IL-13	NNP
cord-015021-pol2qm74	2814	5	may	may	MD
cord-015021-pol2qm74	2814	6	thus	thus	RB
cord-015021-pol2qm74	2814	7	be	be	VB
cord-015021-pol2qm74	2814	8	contributing	contribute	VBG
cord-015021-pol2qm74	2814	9	,	,	,
cord-015021-pol2qm74	2814	10	significantly	significantly	RB
cord-015021-pol2qm74	2814	11	to	to	IN
cord-015021-pol2qm74	2814	12	some	some	DT
cord-015021-pol2qm74	2814	13	of	of	IN
cord-015021-pol2qm74	2814	14	the	the	DT
cord-015021-pol2qm74	2814	15	activites	activite	NNS
cord-015021-pol2qm74	2814	16	previously	previously	RB
cord-015021-pol2qm74	2814	17	ascribed	ascribe	VBN
cord-015021-pol2qm74	2814	18	to	to	IN
cord-015021-pol2qm74	2814	19	IL-4	IL-4	NNP
cord-015021-pol2qm74	2814	20	IL-10	IL-10	NNP
cord-015021-pol2qm74	2814	21	.	.	.
cord-015021-pol2qm74	2815	1	Recently	recently	RB
cord-015021-pol2qm74	2815	2	,	,	,
cord-015021-pol2qm74	2815	3	we	-PRON-	PRP
cord-015021-pol2qm74	2815	4	cloned	clone	VBD
cord-015021-pol2qm74	2815	5	the	the	DT
cord-015021-pol2qm74	2815	6	human	human	JJ
cord-015021-pol2qm74	2815	7	cDNA	cdna	NN
cord-015021-pol2qm74	2815	8	encoding	encode	VBG
cord-015021-pol2qm74	2815	9	Interleukin-13	Interleukin-13	NNP
cord-015021-pol2qm74	2815	10	(	(	-LRB-
cord-015021-pol2qm74	2815	11	IL-13	IL-13	NNP
cord-015021-pol2qm74	2815	12	)	)	-RRB-
cord-015021-pol2qm74	2815	13	.	.	.
cord-015021-pol2qm74	2816	1	Human	Human	NNP
cord-015021-pol2qm74	2816	2	IL-13	IL-13	NNP
cord-015021-pol2qm74	2816	3	is	be	VBZ
cord-015021-pol2qm74	2816	4	a	a	DT
cord-015021-pol2qm74	2816	5	non	non	JJ
cord-015021-pol2qm74	2816	6	-	-	JJ
cord-015021-pol2qm74	2816	7	glycosylated	glycosylated	JJ
cord-015021-pol2qm74	2816	8	protein	protein	NN
cord-015021-pol2qm74	2816	9	of	of	IN
cord-015021-pol2qm74	2816	10	132	132	CD
cord-015021-pol2qm74	2816	11	aa	aa	NN
cord-015021-pol2qm74	2816	12	with	with	IN
cord-015021-pol2qm74	2816	13	a	a	DT
cord-015021-pol2qm74	2816	14	molecular	molecular	JJ
cord-015021-pol2qm74	2816	15	mass	mass	NN
cord-015021-pol2qm74	2816	16	(	(	-LRB-
cord-015021-pol2qm74	2816	17	Mr	Mr	NNP
cord-015021-pol2qm74	2816	18	)	)	-RRB-
cord-015021-pol2qm74	2816	19	of	of	IN
cord-015021-pol2qm74	2816	20	10	10	CD
cord-015021-pol2qm74	2816	21	kD	kD	NNS
cord-015021-pol2qm74	2816	22	and	and	CC
cord-015021-pol2qm74	2816	23	has	have	VBZ
cord-015021-pol2qm74	2816	24	biological	biological	JJ
cord-015021-pol2qm74	2816	25	activities	activity	NNS
cord-015021-pol2qm74	2816	26	on	on	IN
cord-015021-pol2qm74	2816	27	monocytes	monocyte	NNS
cord-015021-pol2qm74	2816	28	and	and	CC
cord-015021-pol2qm74	2816	29	B	b	NN
cord-015021-pol2qm74	2816	30	cells	cell	NNS
cord-015021-pol2qm74	2816	31	,	,	,
cord-015021-pol2qm74	2816	32	IL-13	IL-13	NNP
cord-015021-pol2qm74	2816	33	,	,	,
cord-015021-pol2qm74	2816	34	like	like	IN
cord-015021-pol2qm74	2816	35	IL-4	IL-4	NNP
cord-015021-pol2qm74	2816	36	,	,	,
cord-015021-pol2qm74	2816	37	strongly	strongly	RB
cord-015021-pol2qm74	2816	38	enhanced	enhance	VBD
cord-015021-pol2qm74	2816	39	the	the	DT
cord-015021-pol2qm74	2816	40	expression	expression	NN
cord-015021-pol2qm74	2816	41	of	of	IN
cord-015021-pol2qm74	2816	42	class	class	NN
cord-015021-pol2qm74	2816	43	II	II	NNP
cord-015021-pol2qm74	2816	44	MHC	MHC	NNP
cord-015021-pol2qm74	2816	45	antigens	antigen	NNS
cord-015021-pol2qm74	2816	46	on	on	IN
cord-015021-pol2qm74	2816	47	monocytes	monocyte	NNS
cord-015021-pol2qm74	2816	48	and	and	CC
cord-015021-pol2qm74	2816	49	induced	induce	VBN
cord-015021-pol2qm74	2816	50	expression	expression	NN
cord-015021-pol2qm74	2816	51	of	of	IN
cord-015021-pol2qm74	2816	52	CD23	CD23	NNP
cord-015021-pol2qm74	2816	53	(	(	-LRB-
cord-015021-pol2qm74	2816	54	Fc	Fc	NNP
cord-015021-pol2qm74	2816	55	~	~	NNP
cord-015021-pol2qm74	2816	56	RII	RII	NNP
cord-015021-pol2qm74	2816	57	)	)	-RRB-
cord-015021-pol2qm74	2816	58	.	.	.
cord-015021-pol2qm74	2817	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2817	2	,	,	,
cord-015021-pol2qm74	2817	3	IL-13	IL-13	NNP
cord-015021-pol2qm74	2817	4	,	,	,
cord-015021-pol2qm74	2817	5	like	like	IN
cord-015021-pol2qm74	2817	6	IL-4	IL-4	NNP
cord-015021-pol2qm74	2817	7	and	and	CC
cord-015021-pol2qm74	2817	8	IL~10	IL~10	NNP
cord-015021-pol2qm74	2817	9	,	,	,
cord-015021-pol2qm74	2817	10	inhibited	inhibit	VBD
cord-015021-pol2qm74	2817	11	the	the	DT
cord-015021-pol2qm74	2817	12	production	production	NN
cord-015021-pol2qm74	2817	13	of	of	IN
cord-015021-pol2qm74	2817	14	pro	pro	JJ
cord-015021-pol2qm74	2817	15	-	-	JJ
cord-015021-pol2qm74	2817	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2817	17	cytokines	cytokine	NNS
cord-015021-pol2qm74	2817	18	IL-1	IL-1	NNP
cord-015021-pol2qm74	2817	19	,	,	,
cord-015021-pol2qm74	2817	20	]	]	-RRB-
cord-015021-pol2qm74	2817	21	L-6	L-6	NNP
cord-015021-pol2qm74	2817	22	,	,	,
cord-015021-pol2qm74	2817	23	TNFo~	TNFo~	NNP
cord-015021-pol2qm74	2817	24	and	and	CC
cord-015021-pol2qm74	2817	25	chemokines	chemokine	NNS
cord-015021-pol2qm74	2817	26	MIPlc~	miplc~	NN
cord-015021-pol2qm74	2817	27	and	and	CC
cord-015021-pol2qm74	2817	28	tL-8	tl-8	NN
cord-015021-pol2qm74	2817	29	by	by	IN
cord-015021-pol2qm74	2817	30	LPS	LPS	NNP
cord-015021-pol2qm74	2817	31	activated	activate	VBN
cord-015021-pol2qm74	2817	32	monocytes	monocyte	NNS
cord-015021-pol2qm74	2817	33	.	.	.
cord-015021-pol2qm74	2818	1	Both	both	CC
cord-015021-pol2qm74	2818	2	IL-13	IL-13	NNP
cord-015021-pol2qm74	2818	3	and	and	CC
cord-015021-pol2qm74	2818	4	IL-4	IL-4	NNP
cord-015021-pol2qm74	2818	5	enhanced	enhance	VBD
cord-015021-pol2qm74	2818	6	the	the	DT
cord-015021-pol2qm74	2818	7	production	production	NN
cord-015021-pol2qm74	2818	8	of	of	IN
cord-015021-pol2qm74	2818	9	IL	IL	NNP
cord-015021-pol2qm74	2818	10	-	-	HYPH
cord-015021-pol2qm74	2818	11	lra	lra	NNP
cord-015021-pol2qm74	2818	12	by	by	IN
cord-015021-pol2qm74	2818	13	monocytes	monocyte	NNS
cord-015021-pol2qm74	2818	14	.	.	.
cord-015021-pol2qm74	2819	1	In	in	IN
cord-015021-pol2qm74	2819	2	contrast	contrast	NN
cord-015021-pol2qm74	2819	3	,	,	,
cord-015021-pol2qm74	2819	4	IL-13	IL-13	NNP
cord-015021-pol2qm74	2819	5	lacked	lack	VBD
cord-015021-pol2qm74	2819	6	the	the	DT
cord-015021-pol2qm74	2819	7	T	t	NN
cord-015021-pol2qm74	2819	8	cell	cell	NN
cord-015021-pol2qm74	2819	9	stimulating	stimulate	VBG
cord-015021-pol2qm74	2819	10	activities	activity	NNS
cord-015021-pol2qm74	2819	11	of	of	IN
cord-015021-pol2qm74	2819	12	IL-4	IL-4	NNP
cord-015021-pol2qm74	2819	13	.	.	.
cord-015021-pol2qm74	2820	1	The	the	DT
cord-015021-pol2qm74	2820	2	responses	response	NNS
cord-015021-pol2qm74	2820	3	of	of	IN
cord-015021-pol2qm74	2820	4	monocytes	monocyte	NNS
cord-015021-pol2qm74	2820	5	to	to	IN
cord-015021-pol2qm74	2820	6	IL-13	IL-13	NNP
cord-015021-pol2qm74	2820	7	and	and	CC
cord-015021-pol2qm74	2820	8	IL-4	IL-4	NNP
cord-015021-pol2qm74	2820	9	were	be	VBD
cord-015021-pol2qm74	2820	10	not	not	RB
cord-015021-pol2qm74	2820	11	additive	additive	JJ
cord-015021-pol2qm74	2820	12	or	or	CC
cord-015021-pol2qm74	2820	13	synergistic	synergistic	JJ
cord-015021-pol2qm74	2820	14	,	,	,
cord-015021-pol2qm74	2820	15	supporting	support	VBG
cord-015021-pol2qm74	2820	16	the	the	DT
cord-015021-pol2qm74	2820	17	hypothesis	hypothesis	NN
cord-015021-pol2qm74	2820	18	that	that	IN
cord-015021-pol2qm74	2820	19	IL-13	IL-13	NNP
cord-015021-pol2qm74	2820	20	and	and	CC
cord-015021-pol2qm74	2820	21	IL-4	IL-4	NNP
cord-015021-pol2qm74	2820	22	receptors	receptor	NNS
cord-015021-pol2qm74	2820	23	are	be	VBP
cord-015021-pol2qm74	2820	24	complex	complex	JJ
cord-015021-pol2qm74	2820	25	and	and	CC
cord-015021-pol2qm74	2820	26	share	share	VBP
cord-015021-pol2qm74	2820	27	a	a	DT
cord-015021-pol2qm74	2820	28	common	common	JJ
cord-015021-pol2qm74	2820	29	component	component	NN
cord-015021-pol2qm74	2820	30	which	which	WDT
cord-015021-pol2qm74	2820	31	is	be	VBZ
cord-015021-pol2qm74	2820	32	important	important	JJ
cord-015021-pol2qm74	2820	33	for	for	IN
cord-015021-pol2qm74	2820	34	signal	signal	NN
cord-015021-pol2qm74	2820	35	transduction	transduction	NN
cord-015021-pol2qm74	2820	36	,	,	,
cord-015021-pol2qm74	2820	37	Taken	take	VBN
cord-015021-pol2qm74	2820	38	together	together	RB
cord-015021-pol2qm74	2820	39	,	,	,
cord-015021-pol2qm74	2820	40	these	these	DT
cord-015021-pol2qm74	2820	41	data	datum	NNS
cord-015021-pol2qm74	2820	42	indicate	indicate	VBP
cord-015021-pol2qm74	2820	43	that	that	IN
cord-015021-pol2qm74	2820	44	IL-13	IL-13	NNP
cord-015021-pol2qm74	2820	45	,	,	,
cord-015021-pol2qm74	2820	46	IL~4	IL~4	NNP
cord-015021-pol2qm74	2820	47	and	and	CC
cord-015021-pol2qm74	2820	48	IL-10	IL-10	NNP
cord-015021-pol2qm74	2820	49	have	have	VBP
cord-015021-pol2qm74	2820	50	important	important	JJ
cord-015021-pol2qm74	2820	51	anti	anti	JJ
cord-015021-pol2qm74	2820	52	-	-	JJ
cord-015021-pol2qm74	2820	53	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2820	54	activities	activity	NNS
cord-015021-pol2qm74	2820	55	on	on	IN
cord-015021-pol2qm74	2820	56	human	human	JJ
cord-015021-pol2qm74	2820	57	monocytes	monocyte	NNS
cord-015021-pol2qm74	2820	58	.	.	.
cord-015021-pol2qm74	2821	1	In	in	IN
cord-015021-pol2qm74	2821	2	addition	addition	NN
cord-015021-pol2qm74	2821	3	,	,	,
cord-015021-pol2qm74	2821	4	these	these	DT
cord-015021-pol2qm74	2821	5	results	result	NNS
cord-015021-pol2qm74	2821	6	indicate	indicate	VBP
cord-015021-pol2qm74	2821	7	that	that	IN
cord-015021-pol2qm74	2821	8	IL-13	IL-13	NNP
cord-015021-pol2qm74	2821	9	is	be	VBZ
cord-015021-pol2qm74	2821	10	unique	unique	JJ
cord-015021-pol2qm74	2821	11	in	in	IN
cord-015021-pol2qm74	2821	12	that	that	IN
cord-015021-pol2qm74	2821	13	it	-PRON-	PRP
cord-015021-pol2qm74	2821	14	can	can	MD
cord-015021-pol2qm74	2821	15	modify	modify	VB
cord-015021-pol2qm74	2821	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2821	17	reactions	reaction	NNS
cord-015021-pol2qm74	2821	18	without	without	IN
cord-015021-pol2qm74	2821	19	stimulating	stimulate	VBG
cord-015021-pol2qm74	2821	20	(	(	-LRB-
cord-015021-pol2qm74	2821	21	as	as	IN
cord-015021-pol2qm74	2821	22	does	do	VBZ
cord-015021-pol2qm74	2821	23	IL-4	IL-4	NNP
cord-015021-pol2qm74	2821	24	)	)	-RRB-
cord-015021-pol2qm74	2821	25	or	or	CC
cord-015021-pol2qm74	2821	26	inhibiting	inhibit	VBG
cord-015021-pol2qm74	2821	27	(	(	-LRB-
cord-015021-pol2qm74	2821	28	as	as	IN
cord-015021-pol2qm74	2821	29	does	do	VBZ
cord-015021-pol2qm74	2821	30	IL-10	IL-10	NNP
cord-015021-pol2qm74	2821	31	)	)	-RRB-
cord-015021-pol2qm74	2821	32	T	t	NN
cord-015021-pol2qm74	2821	33	cell	cell	NN
cord-015021-pol2qm74	2821	34	responses	response	NNS
cord-015021-pol2qm74	2821	35	.	.	.
cord-015021-pol2qm74	2822	1	Transforming	transform	VBG
cord-015021-pol2qm74	2822	2	growth	growth	NN
cord-015021-pol2qm74	2822	3	factor	factor	NN
cord-015021-pol2qm74	2822	4	beta	beta	NN
cord-015021-pol2qm74	2822	5	I	i	NN
cord-015021-pol2qm74	2822	6	(	(	-LRB-
cord-015021-pol2qm74	2822	7	TGF	TGF	NNP
cord-015021-pol2qm74	2822	8	-	-	HYPH
cord-015021-pol2qm74	2822	9	fll	fll	NNP
cord-015021-pol2qm74	2822	10	)	)	-RRB-
cord-015021-pol2qm74	2822	11	belongs	belong	VBZ
cord-015021-pol2qm74	2822	12	to	to	IN
cord-015021-pol2qm74	2822	13	a	a	DT
cord-015021-pol2qm74	2822	14	family	family	NN
cord-015021-pol2qm74	2822	15	of	of	IN
cord-015021-pol2qm74	2822	16	proteins	protein	NNS
cord-015021-pol2qm74	2822	17	that	that	WDT
cord-015021-pol2qm74	2822	18	have	have	VBP
cord-015021-pol2qm74	2822	19	potent	potent	JJ
cord-015021-pol2qm74	2822	20	immunoregulatory	immunoregulatory	JJ
cord-015021-pol2qm74	2822	21	properties	property	NNS
cord-015021-pol2qm74	2822	22	ranging	range	VBG
cord-015021-pol2qm74	2822	23	ftom	ftom	JJ
cord-015021-pol2qm74	2822	24	effects	effect	NNS
cord-015021-pol2qm74	2822	25	on	on	IN
cord-015021-pol2qm74	2822	26	the	the	DT
cord-015021-pol2qm74	2822	27	growth	growth	NN
cord-015021-pol2qm74	2822	28	and	and	CC
cord-015021-pol2qm74	2822	29	dfflerentiafion	dfflerentiafion	NN
cord-015021-pol2qm74	2822	30	of	of	IN
cord-015021-pol2qm74	2822	31	primitive	primitive	JJ
cord-015021-pol2qm74	2822	32	stem	stem	NN
cord-015021-pol2qm74	2822	33	cells	cell	NNS
cord-015021-pol2qm74	2822	34	to	to	IN
cord-015021-pol2qm74	2822	35	the	the	DT
cord-015021-pol2qm74	2822	36	differentiated	differentiated	JJ
cord-015021-pol2qm74	2822	37	functions	function	NNS
cord-015021-pol2qm74	2822	38	of	of	IN
cord-015021-pol2qm74	2822	39	immune	immune	JJ
cord-015021-pol2qm74	2822	40	system	system	NN
cord-015021-pol2qm74	2822	41	effector	effector	NN
cord-015021-pol2qm74	2822	42	cells	cell	NNS
cord-015021-pol2qm74	2822	43	.	.	.
cord-015021-pol2qm74	2823	1	TGF	TGF	NNP
cord-015021-pol2qm74	2823	2	-	-	HYPH
cord-015021-pol2qm74	2823	3	I	I	NNP
cord-015021-pol2qm74	2824	1	~I	~I	NFP
cord-015021-pol2qm74	2824	2	is	be	VBZ
cord-015021-pol2qm74	2824	3	synthesized	synthesize	VBN
cord-015021-pol2qm74	2824	4	as	as	IN
cord-015021-pol2qm74	2824	5	a	a	DT
cord-015021-pol2qm74	2824	6	large	large	JJ
cord-015021-pol2qm74	2824	7	secretory	secretory	JJ
cord-015021-pol2qm74	2824	8	precursor	precursor	NN
cord-015021-pol2qm74	2824	9	polypeptide	polypeptide	NN
cord-015021-pol2qm74	2824	10	of	of	IN
cord-015021-pol2qm74	2824	11	390	390	CD
cord-015021-pol2qm74	2824	12	amino	amino	JJ
cord-015021-pol2qm74	2824	13	acids	acid	NNS
cord-015021-pol2qm74	2824	14	that	that	WDT
cord-015021-pol2qm74	2824	15	is	be	VBZ
cord-015021-pol2qm74	2824	16	inactive	inactive	JJ
cord-015021-pol2qm74	2824	17	until	until	IN
cord-015021-pol2qm74	2824	18	processed	process	VBN
cord-015021-pol2qm74	2824	19	to	to	IN
cord-015021-pol2qm74	2824	20	a	a	DT
cord-015021-pol2qm74	2824	21	disulfide	disulfide	NN
cord-015021-pol2qm74	2824	22	linked	link	VBN
cord-015021-pol2qm74	2824	23	homodimeric	homodimeric	JJ
cord-015021-pol2qm74	2824	24	molecule	molecule	NN
cord-015021-pol2qm74	2824	25	of	of	IN
cord-015021-pol2qm74	2824	26	1t2	1t2	CD
cord-015021-pol2qm74	2824	27	amino	amino	NN
cord-015021-pol2qm74	2824	28	acids	acid	NNS
cord-015021-pol2qm74	2824	29	each	each	DT
cord-015021-pol2qm74	2824	30	.	.	.
cord-015021-pol2qm74	2825	1	Recently	recently	RB
cord-015021-pol2qm74	2825	2	it	-PRON-	PRP
cord-015021-pol2qm74	2825	3	has	have	VBZ
cord-015021-pol2qm74	2825	4	been	be	VBN
cord-015021-pol2qm74	2825	5	found	find	VBN
cord-015021-pol2qm74	2825	6	that	that	IN
cord-015021-pol2qm74	2825	7	TGF-[~I	tgf-[~i	NN
cord-015021-pol2qm74	2825	8	can	can	MD
cord-015021-pol2qm74	2825	9	have	have	VB
cord-015021-pol2qm74	2825	10	autocrine	autocrine	NN
cord-015021-pol2qm74	2825	11	as	as	RB
cord-015021-pol2qm74	2825	12	well	well	RB
cord-015021-pol2qm74	2825	13	as	as	IN
cord-015021-pol2qm74	2825	14	paracrine	paracrine	JJ
cord-015021-pol2qm74	2825	15	effects	effect	NNS
cord-015021-pol2qm74	2825	16	on	on	IN
cord-015021-pol2qm74	2825	17	the	the	DT
cord-015021-pol2qm74	2825	18	immune	immune	JJ
cord-015021-pol2qm74	2825	19	system	system	NN
cord-015021-pol2qm74	2825	20	indicating	indicate	VBG
cord-015021-pol2qm74	2825	21	that	that	IN
cord-015021-pol2qm74	2825	22	immune	immune	JJ
cord-015021-pol2qm74	2825	23	cells	cell	NNS
cord-015021-pol2qm74	2825	24	can	can	MD
cord-015021-pol2qm74	2825	25	activate	activate	VB
cord-015021-pol2qm74	2825	26	the	the	DT
cord-015021-pol2qm74	2825	27	inactive	inactive	JJ
cord-015021-pol2qm74	2825	28	secreted	secrete	VBN
cord-015021-pol2qm74	2825	29	form	form	NN
cord-015021-pol2qm74	2825	30	of	of	IN
cord-015021-pol2qm74	2825	31	TGI~-~I.	TGI~-~I.	NNP
cord-015021-pol2qm74	2826	1	In	in	IN
cord-015021-pol2qm74	2826	2	addition	addition	NN
cord-015021-pol2qm74	2826	3	,	,	,
cord-015021-pol2qm74	2826	4	TGF	TGF	NNP
cord-015021-pol2qm74	2826	5	-	-	HYPH
cord-015021-pol2qm74	2826	6	I	I	NNP
cord-015021-pol2qm74	2826	7	~	~	NFP
cord-015021-pol2qm74	2826	8	I	-PRON-	PRP
cord-015021-pol2qm74	2826	9	has	have	VBZ
cord-015021-pol2qm74	2826	10	differential	differential	JJ
cord-015021-pol2qm74	2826	11	intraceUular	intraceuular	JJ
cord-015021-pol2qm74	2826	12	effects	effect	NNS
cord-015021-pol2qm74	2826	13	on	on	IN
cord-015021-pol2qm74	2826	14	cell	cell	NN
cord-015021-pol2qm74	2826	15	surface	surface	NN
cord-015021-pol2qm74	2826	16	receptor	receptor	NN
cord-015021-pol2qm74	2826	17	modulation	modulation	NN
cord-015021-pol2qm74	2826	18	,	,	,
cord-015021-pol2qm74	2826	19	tyrosine	tyrosine	NN
cord-015021-pol2qm74	2826	20	phosphorylation	phosphorylation	NN
cord-015021-pol2qm74	2826	21	and	and	CC
cord-015021-pol2qm74	2826	22	cytokine	cytokine	NN
cord-015021-pol2qm74	2826	23	gene	gene	NN
cord-015021-pol2qm74	2826	24	transcription	transcription	NN
cord-015021-pol2qm74	2826	25	as	as	RB
cord-015021-pol2qm74	2826	26	well	well	RB
cord-015021-pol2qm74	2826	27	as	as	IN
cord-015021-pol2qm74	2826	28	cell	cell	NN
cord-015021-pol2qm74	2826	29	mediated	mediate	VBN
cord-015021-pol2qm74	2826	30	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	2826	31	.	.	.
cord-015021-pol2qm74	2827	1	The	the	DT
cord-015021-pol2qm74	2827	2	systemic	systemic	JJ
cord-015021-pol2qm74	2827	3	administration	administration	NN
cord-015021-pol2qm74	2827	4	of	of	IN
cord-015021-pol2qm74	2827	5	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2827	6	has	have	VBZ
cord-015021-pol2qm74	2827	7	proven	prove	VBN
cord-015021-pol2qm74	2827	8	beneficial	beneficial	JJ
cord-015021-pol2qm74	2827	9	in	in	IN
cord-015021-pol2qm74	2827	10	a	a	DT
cord-015021-pol2qm74	2827	11	variety	variety	NN
cord-015021-pol2qm74	2827	12	of	of	IN
cord-015021-pol2qm74	2827	13	animal	animal	NN
cord-015021-pol2qm74	2827	14	models	model	NNS
cord-015021-pol2qm74	2827	15	such	such	JJ
cord-015021-pol2qm74	2827	16	as	as	IN
cord-015021-pol2qm74	2827	17	septic	septic	JJ
cord-015021-pol2qm74	2827	18	shock	shock	NN
cord-015021-pol2qm74	2827	19	,	,	,
cord-015021-pol2qm74	2827	20	allograft	allograft	NN
cord-015021-pol2qm74	2827	21	rejection	rejection	NN
cord-015021-pol2qm74	2827	22	and	and	CC
cord-015021-pol2qm74	2827	23	experimental	experimental	JJ
cord-015021-pol2qm74	2827	24	forms	form	NNS
cord-015021-pol2qm74	2827	25	of	of	IN
cord-015021-pol2qm74	2827	26	autoimmunity	autoimmunity	NN
cord-015021-pol2qm74	2827	27	including	include	VBG
cord-015021-pol2qm74	2827	28	collagen	collagen	NN
cord-015021-pol2qm74	2827	29	induced	induce	VBN
cord-015021-pol2qm74	2827	30	arthritis	arthritis	NN
cord-015021-pol2qm74	2827	31	and	and	CC
cord-015021-pol2qm74	2827	32	experimental	experimental	JJ
cord-015021-pol2qm74	2827	33	autoimmune	autoimmune	JJ
cord-015021-pol2qm74	2827	34	encephalomyelitis	encephalomyelitis	NN
cord-015021-pol2qm74	2827	35	.	.	.
cord-015021-pol2qm74	2828	1	Moreover	moreover	RB
cord-015021-pol2qm74	2828	2	the	the	DT
cord-015021-pol2qm74	2828	3	increased	increase	VBN
cord-015021-pol2qm74	2828	4	levels	level	NNS
cord-015021-pol2qm74	2828	5	of	of	IN
cord-015021-pol2qm74	2828	6	TGF	TGF	NNP
cord-015021-pol2qm74	2829	1	-Ill	-Ill	:
cord-015021-pol2qm74	2829	2	and	and	CC
cord-015021-pol2qm74	2829	3	other	other	JJ
cord-015021-pol2qm74	2829	4	TGF-13	tgf-13	CD
cord-015021-pol2qm74	2829	5	isoforms	isoform	NNS
cord-015021-pol2qm74	2829	6	found	find	VBN
cord-015021-pol2qm74	2829	7	in	in	IN
cord-015021-pol2qm74	2829	8	several	several	JJ
cord-015021-pol2qm74	2829	9	disease	disease	NN
cord-015021-pol2qm74	2829	10	states	state	NNS
cord-015021-pol2qm74	2829	11	associated	associate	VBN
cord-015021-pol2qm74	2829	12	with	with	IN
cord-015021-pol2qm74	2829	13	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	2829	14	such	such	JJ
cord-015021-pol2qm74	2829	15	as	as	IN
cord-015021-pol2qm74	2829	16	different	different	JJ
cord-015021-pol2qm74	2829	17	forms	form	NNS
cord-015021-pol2qm74	2829	18	of	of	IN
cord-015021-pol2qm74	2829	19	malignancy	malignancy	NN
cord-015021-pol2qm74	2829	20	,	,	,
cord-015021-pol2qm74	2829	21	chronic	chronic	JJ
cord-015021-pol2qm74	2829	22	degenerative	degenerative	JJ
cord-015021-pol2qm74	2829	23	diseases	disease	NNS
cord-015021-pol2qm74	2829	24	and	and	CC
cord-015021-pol2qm74	2829	25	AIDS	AIDS	NNP
cord-015021-pol2qm74	2829	26	implicate	implicate	VBP
cord-015021-pol2qm74	2829	27	the	the	DT
cord-015021-pol2qm74	2829	28	involvement	involvement	NN
cord-015021-pol2qm74	2829	29	of	of	IN
cord-015021-pol2qm74	2829	30	TGt~-I~	TGt~-I~	NNP
cord-015021-pol2qm74	2829	31	in	in	IN
cord-015021-pol2qm74	2829	32	the	the	DT
cord-015021-pol2qm74	2829	33	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	2829	34	of	of	IN
cord-015021-pol2qm74	2829	35	some	some	DT
cord-015021-pol2qm74	2829	36	diseases	disease	NNS
cord-015021-pol2qm74	2829	37	.	.	.
cord-015021-pol2qm74	2830	1	Hopefully	hopefully	RB
cord-015021-pol2qm74	2830	2	,	,	,
cord-015021-pol2qm74	2830	3	well	well	RB
cord-015021-pol2qm74	2830	4	designed	design	VBN
cord-015021-pol2qm74	2830	5	clinical	clinical	JJ
cord-015021-pol2qm74	2830	6	trials	trial	NNS
cord-015021-pol2qm74	2830	7	will	will	MD
cord-015021-pol2qm74	2830	8	define	define	VB
cord-015021-pol2qm74	2830	9	the	the	DT
cord-015021-pol2qm74	2830	10	potential	potential	JJ
cord-015021-pol2qm74	2830	11	roles	role	NNS
cord-015021-pol2qm74	2830	12	of	of	IN
cord-015021-pol2qm74	2830	13	the	the	DT
cord-015021-pol2qm74	2830	14	TGF-[3	TGF-[3	NNP
cord-015021-pol2qm74	2830	15	family	family	NN
cord-015021-pol2qm74	2830	16	of	of	IN
cord-015021-pol2qm74	2830	17	proteins	protein	NNS
cord-015021-pol2qm74	2830	18	in	in	IN
cord-015021-pol2qm74	2830	19	the	the	DT
cord-015021-pol2qm74	2830	20	treatment	treatment	NN
cord-015021-pol2qm74	2830	21	of	of	IN
cord-015021-pol2qm74	2830	22	diseases	disease	NNS
cord-015021-pol2qm74	2830	23	of	of	IN
cord-015021-pol2qm74	2830	24	man	man	NN
cord-015021-pol2qm74	2830	25	.	.	.
cord-015021-pol2qm74	2831	1	Patient	patient	JJ
cord-015021-pol2qm74	2831	2	development	development	NN
cord-015021-pol2qm74	2831	3	of	of	IN
cord-015021-pol2qm74	2831	4	systemic	systemic	JJ
cord-015021-pol2qm74	2831	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2831	6	response	response	NN
cord-015021-pol2qm74	2831	7	syndrome	syndrome	NN
cord-015021-pol2qm74	2831	8	(	(	-LRB-
cord-015021-pol2qm74	2831	9	SIS	SIS	NNP
cord-015021-pol2qm74	2831	10	)	)	-RRB-
cord-015021-pol2qm74	2831	11	after	after	IN
cord-015021-pol2qm74	2831	12	severe	severe	JJ
cord-015021-pol2qm74	2831	13	trauma	trauma	NN
cord-015021-pol2qm74	2831	14	is	be	VBZ
cord-015021-pol2qm74	2831	15	accompanied	accompany	VBN
cord-015021-pol2qm74	2831	16	by	by	IN
cord-015021-pol2qm74	2831	17	a	a	DT
cord-015021-pol2qm74	2831	18	wide	wide	JJ
cord-015021-pol2qm74	2831	19	range	range	NN
cord-015021-pol2qm74	2831	20	of	of	IN
cord-015021-pol2qm74	2831	21	immune	immune	JJ
cord-015021-pol2qm74	2831	22	aberrations	aberration	NNS
cord-015021-pol2qm74	2831	23	and	and	CC
cord-015021-pol2qm74	2831	24	altered	alter	VBN
cord-015021-pol2qm74	2831	25	cytokine	cytokine	NN
cord-015021-pol2qm74	2831	26	production	production	NN
cord-015021-pol2qm74	2831	27	.	.	.
cord-015021-pol2qm74	2832	1	In	in	IN
cord-015021-pol2qm74	2832	2	particular	particular	JJ
cord-015021-pol2qm74	2832	3	,	,	,
cord-015021-pol2qm74	2832	4	T	t	NN
cord-015021-pol2qm74	2832	5	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	2832	6	proliferation	proliferation	NN
cord-015021-pol2qm74	2832	7	and	and	CC
cord-015021-pol2qm74	2832	8	IFN	IFN	NNP
cord-015021-pol2qm74	2832	9	,	,	,
cord-015021-pol2qm74	2832	10	t	t	NN
cord-015021-pol2qm74	2832	11	production	production	NN
cord-015021-pol2qm74	2832	12	is	be	VBZ
cord-015021-pol2qm74	2832	13	suppressed	suppress	VBN
cord-015021-pol2qm74	2832	14	while	while	IN
cord-015021-pol2qm74	2832	15	monocyte	monocyte	NNP
cord-015021-pol2qm74	2832	16	(	(	-LRB-
cord-015021-pol2qm74	2832	17	MO	MO	NNP
cord-015021-pol2qm74	2832	18	)	)	-RRB-
cord-015021-pol2qm74	2833	1	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	2833	2	,	,	,
cord-015021-pol2qm74	2833	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	2833	4	,	,	,
cord-015021-pol2qm74	2833	5	PGE2	PGE2	NNP
cord-015021-pol2qm74	2833	6	and	and	CC
cord-015021-pol2qm74	2833	7	TGF~	TGF~	NNP
cord-015021-pol2qm74	2833	8	production	production	NN
cord-015021-pol2qm74	2833	9	is	be	VBZ
cord-015021-pol2qm74	2833	10	massively	massively	RB
cord-015021-pol2qm74	2833	11	increased	increase	VBN
cord-015021-pol2qm74	2833	12	concomitant	concomitant	JJ
cord-015021-pol2qm74	2833	13	to	to	IN
cord-015021-pol2qm74	2833	14	decreased	decrease	VBN
cord-015021-pol2qm74	2833	15	antigen	antigen	NN
cord-015021-pol2qm74	2833	16	presenting	present	VBG
cord-015021-pol2qm74	2833	17	capacity	capacity	NN
cord-015021-pol2qm74	2833	18	.	.	.
cord-015021-pol2qm74	2834	1	Recently	recently	RB
cord-015021-pol2qm74	2834	2	,	,	,
cord-015021-pol2qm74	2834	3	two	two	CD
cord-015021-pol2qm74	2834	4	new	new	JJ
cord-015021-pol2qm74	2834	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	2834	6	,	,	,
cord-015021-pol2qm74	2834	7	IL-10	IL-10	NNP
cord-015021-pol2qm74	2834	8	and	and	CC
cord-015021-pol2qm74	2834	9	IL-12	IL-12	NNP
cord-015021-pol2qm74	2834	10	,	,	,
cord-015021-pol2qm74	2834	11	have	have	VBP
cord-015021-pol2qm74	2834	12	been	be	VBN
cord-015021-pol2qm74	2834	13	characterized	characterize	VBN
cord-015021-pol2qm74	2834	14	as	as	IN
cord-015021-pol2qm74	2834	15	critical	critical	JJ
cord-015021-pol2qm74	2834	16	in	in	IN
cord-015021-pol2qm74	2834	17	regulation	regulation	NN
cord-015021-pol2qm74	2834	18	of	of	IN
cord-015021-pol2qm74	2834	19	MO	MO	NNP
cord-015021-pol2qm74	2834	20	TNFa	TNFa	NNP
cord-015021-pol2qm74	2834	21	and	and	CC
cord-015021-pol2qm74	2834	22	IL-6	IL-6	NNP
cord-015021-pol2qm74	2834	23	,	,	,
cord-015021-pol2qm74	2834	24	as	as	RB
cord-015021-pol2qm74	2834	25	well	well	RB
cord-015021-pol2qm74	2834	26	as	as	IN
cord-015021-pol2qm74	2834	27	in	in	IN
cord-015021-pol2qm74	2834	28	induction	induction	NN
cord-015021-pol2qm74	2834	29	of	of	IN
cord-015021-pol2qm74	2834	30	T	t	NN
cord-015021-pol2qm74	2834	31	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	2834	32	proliferation	proliferation	NN
cord-015021-pol2qm74	2834	33	and	and	CC
cord-015021-pol2qm74	2834	34	IFN	IFN	NNP
cord-015021-pol2qm74	2834	35	7	7	CD
cord-015021-pol2qm74	2834	36	production	production	NN
cord-015021-pol2qm74	2834	37	.	.	.
cord-015021-pol2qm74	2835	1	In	in	IN
cord-015021-pol2qm74	2835	2	this	this	DT
cord-015021-pol2qm74	2835	3	study	study	NN
cord-015021-pol2qm74	2835	4	,	,	,
cord-015021-pol2qm74	2835	5	peripheral	peripheral	JJ
cord-015021-pol2qm74	2835	6	blood	blood	NN
cord-015021-pol2qm74	2835	7	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2835	8	(	(	-LRB-
cord-015021-pol2qm74	2835	9	PBL	PBL	NNP
cord-015021-pol2qm74	2835	10	)	)	-RRB-
cord-015021-pol2qm74	2835	11	from	from	IN
cord-015021-pol2qm74	2835	12	severe	severe	JJ
cord-015021-pol2qm74	2835	13	trauma	trauma	NN
cord-015021-pol2qm74	2835	14	patients	patient	NNS
cord-015021-pol2qm74	2835	15	(	(	-LRB-
cord-015021-pol2qm74	2835	16	Injury	injury	NN
cord-015021-pol2qm74	2835	17	Severity	severity	NN
cord-015021-pol2qm74	2835	18	Score	score	NN
cord-015021-pol2qm74	2835	19	>	>	XX
cord-015021-pol2qm74	2835	20	35	35	CD
cord-015021-pol2qm74	2835	21	)	)	-RRB-
cord-015021-pol2qm74	2835	22	were	be	VBD
cord-015021-pol2qm74	2835	23	analyzed	analyze	VBN
cord-015021-pol2qm74	2835	24	for	for	IN
cord-015021-pol2qm74	2835	25	their	-PRON-	PRP$
cord-015021-pol2qm74	2835	26	IL-10	IL-10	NNP
cord-015021-pol2qm74	2835	27	levels	level	NNS
cord-015021-pol2qm74	2835	28	,	,	,
cord-015021-pol2qm74	2835	29	their	-PRON-	PRP$
cord-015021-pol2qm74	2835	30	in	in	FW
cord-015021-pol2qm74	2835	31	vitro	vitro	FW
cord-015021-pol2qm74	2835	32	proliferation	proliferation	NN
cord-015021-pol2qm74	2835	33	to	to	IN
cord-015021-pol2qm74	2835	34	mitogen	mitogen	NNP
cord-015021-pol2qm74	2835	35	(	(	-LRB-
cord-015021-pol2qm74	2835	36	PHA	PHA	NNP
cord-015021-pol2qm74	2835	37	)	)	-RRB-
cord-015021-pol2qm74	2835	38	and	and	CC
cord-015021-pol2qm74	2835	39	their	-PRON-	PRP$
cord-015021-pol2qm74	2835	40	response	response	NN
cord-015021-pol2qm74	2835	41	after	after	IN
cord-015021-pol2qm74	2835	42	IL-12	IL-12	NNP
cord-015021-pol2qm74	2835	43	addition	addition	NN
cord-015021-pol2qm74	2835	44	.	.	.
cord-015021-pol2qm74	2836	1	Since	since	IN
cord-015021-pol2qm74	2836	2	IL-10	IL-10	NNP
cord-015021-pol2qm74	2836	3	produced	produce	VBD
cord-015021-pol2qm74	2836	4	either	either	CC
cord-015021-pol2qm74	2836	5	by	by	IN
cord-015021-pol2qm74	2836	6	MO	MO	NNP
cord-015021-pol2qm74	2836	7	or	or	CC
cord-015021-pol2qm74	2836	8	by	by	IN
cord-015021-pol2qm74	2836	9	T	T	NNP
cord-015021-pol2qm74	2836	10	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2836	11	can	can	MD
cord-015021-pol2qm74	2836	12	depress	depress	VB
cord-015021-pol2qm74	2836	13	M~	M~	NNP
cord-015021-pol2qm74	2836	14	antigen	antigen	NN
cord-015021-pol2qm74	2836	15	presenting	present	VBG
cord-015021-pol2qm74	2836	16	capacity	capacity	NN
cord-015021-pol2qm74	2836	17	,	,	,
cord-015021-pol2qm74	2836	18	inhibit	inhibit	VB
cord-015021-pol2qm74	2836	19	T	t	NN
cord-015021-pol2qm74	2836	20	cell	cell	NN
cord-015021-pol2qm74	2836	21	IFN,/production	ifn,/production	NN
cord-015021-pol2qm74	2836	22	and	and	CC
cord-015021-pol2qm74	2836	23	directly	directly	RB
cord-015021-pol2qm74	2836	24	diminish	diminish	VB
cord-015021-pol2qm74	2836	25	T	t	NN
cord-015021-pol2qm74	2836	26	cell	cell	NN
cord-015021-pol2qm74	2836	27	proliferation	proliferation	NN
cord-015021-pol2qm74	2836	28	,	,	,
cord-015021-pol2qm74	2836	29	it	-PRON-	PRP
cord-015021-pol2qm74	2836	30	might	may	MD
cord-015021-pol2qm74	2836	31	be	be	VB
cord-015021-pol2qm74	2836	32	suggested	suggest	VBN
cord-015021-pol2qm74	2836	33	that	that	IN
cord-015021-pol2qm74	2836	34	immunosuppressed	immunosuppressed	JJ
cord-015021-pol2qm74	2836	35	patients	patient	NNS
cord-015021-pol2qm74	2836	36	'	'	POS
cord-015021-pol2qm74	2836	37	MO	MO	NNP
cord-015021-pol2qm74	2836	38	and/or	and/or	CC
cord-015021-pol2qm74	2836	39	T	T	NNP
cord-015021-pol2qm74	2836	40	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2836	41	would	would	MD
cord-015021-pol2qm74	2836	42	have	have	VB
cord-015021-pol2qm74	2836	43	increased	increase	VBN
cord-015021-pol2qm74	2836	44	IL-10	IL-10	NNP
cord-015021-pol2qm74	2836	45	levels	level	NNS
cord-015021-pol2qm74	2836	46	.	.	.
cord-015021-pol2qm74	2837	1	Increased	increase	VBN
cord-015021-pol2qm74	2837	2	patient	patient	NN
cord-015021-pol2qm74	2837	3	IL-10	IL-10	NNP
cord-015021-pol2qm74	2837	4	production	production	NN
cord-015021-pol2qm74	2837	5	might	may	MD
cord-015021-pol2qm74	2837	6	also	also	RB
cord-015021-pol2qm74	2837	7	be	be	VB
cord-015021-pol2qm74	2837	8	resulting	result	VBG
cord-015021-pol2qm74	2837	9	from	from	IN
cord-015021-pol2qm74	2837	10	the	the	DT
cord-015021-pol2qm74	2837	11	high	high	JJ
cord-015021-pol2qm74	2837	12	levels	level	NNS
cord-015021-pol2qm74	2837	13	of	of	IN
cord-015021-pol2qm74	2837	14	TNFa	TNFa	NNS
cord-015021-pol2qm74	2837	15	a	a	DT
cord-015021-pol2qm74	2837	16	known	know	VBN
cord-015021-pol2qm74	2837	17	stimulator	stimulator	NN
cord-015021-pol2qm74	2837	18	of	of	IN
cord-015021-pol2qm74	2837	19	IL-10	IL-10	NNP
cord-015021-pol2qm74	2837	20	.	.	.
cord-015021-pol2qm74	2838	1	Conversely	conversely	RB
cord-015021-pol2qm74	2838	2	,	,	,
cord-015021-pol2qm74	2838	3	since	since	IN
cord-015021-pol2qm74	2838	4	IL-12	IL-12	NNP
cord-015021-pol2qm74	2838	5	augments	augment	VBZ
cord-015021-pol2qm74	2838	6	MO	MO	NNP
cord-015021-pol2qm74	2838	7	antigenpresenting	antigenpresenting	NN
cord-015021-pol2qm74	2838	8	capacity	capacity	NN
cord-015021-pol2qm74	2838	9	,	,	,
cord-015021-pol2qm74	2838	10	Thl	Thl	NNP
cord-015021-pol2qm74	2838	11	induction	induction	NN
cord-015021-pol2qm74	2838	12	and	and	CC
cord-015021-pol2qm74	2838	13	proliferation	proliferation	NN
cord-015021-pol2qm74	2838	14	,	,	,
cord-015021-pol2qm74	2838	15	post	post	JJ
cord-015021-pol2qm74	2838	16	-	-	JJ
cord-015021-pol2qm74	2838	17	trauma	trauma	JJ
cord-015021-pol2qm74	2838	18	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2838	19	might	may	MD
cord-015021-pol2qm74	2838	20	be	be	VB
cord-015021-pol2qm74	2838	21	IL-12	IL-12	NNP
cord-015021-pol2qm74	2838	22	deficient	deficient	JJ
cord-015021-pol2qm74	2838	23	.	.	.
cord-015021-pol2qm74	2839	1	PBL	PBL	NNP
cord-015021-pol2qm74	2839	2	of	of	IN
cord-015021-pol2qm74	2839	3	trauma	trauma	NN
cord-015021-pol2qm74	2839	4	patients	patient	NNS
cord-015021-pol2qm74	2839	5	were	be	VBD
cord-015021-pol2qm74	2839	6	compared	compare	VBN
cord-015021-pol2qm74	2839	7	to	to	IN
cord-015021-pol2qm74	2839	8	normals	normal	NNS
cord-015021-pol2qm74	2839	9	'	'	POS
cord-015021-pol2qm74	2839	10	PBL	PBL	NNP
cord-015021-pol2qm74	2839	11	,	,	,
cord-015021-pol2qm74	2839	12	either	either	CC
cord-015021-pol2qm74	2839	13	unstimulated	unstimulated	JJ
cord-015021-pol2qm74	2839	14	or	or	CC
cord-015021-pol2qm74	2839	15	PttA	PttA	NNP
cord-015021-pol2qm74	2839	16	induced	induce	VBN
cord-015021-pol2qm74	2839	17	,	,	,
cord-015021-pol2qm74	2839	18	and	and	CC
cord-015021-pol2qm74	2839	19	their	-PRON-	PRP$
cord-015021-pol2qm74	2839	20	levels	level	NNS
cord-015021-pol2qm74	2839	21	of	of	IN
cord-015021-pol2qm74	2839	22	IL-10	IL-10	NNP
cord-015021-pol2qm74	2839	23	found	find	VBD
cord-015021-pol2qm74	2839	24	to	to	TO
cord-015021-pol2qm74	2839	25	be	be	VB
cord-015021-pol2qm74	2839	26	dramatically	dramatically	RB
cord-015021-pol2qm74	2839	27	and	and	CC
cord-015021-pol2qm74	2839	28	significantly	significantly	RB
cord-015021-pol2qm74	2839	29	reduced	reduce	VBN
cord-015021-pol2qm74	2839	30	.	.	.
cord-015021-pol2qm74	2840	1	Patients	patient	NNS
cord-015021-pol2qm74	2840	2	'	'	POS
cord-015021-pol2qm74	2840	3	isolated	isolate	VBN
cord-015021-pol2qm74	2840	4	M~	m~	NN
cord-015021-pol2qm74	2840	5	,	,	,
cord-015021-pol2qm74	2840	6	either	either	CC
cord-015021-pol2qm74	2840	7	stimulated	stimulate	VBN
cord-015021-pol2qm74	2840	8	with	with	IN
cord-015021-pol2qm74	2840	9	the	the	DT
cord-015021-pol2qm74	2840	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	2840	11	cell	cell	NN
cord-015021-pol2qm74	2840	12	wall	wall	NN
cord-015021-pol2qm74	2840	13	analogue	analogue	NNP
cord-015021-pol2qm74	2840	14	,	,	,
cord-015021-pol2qm74	2840	15	MDP	MDP	NNP
cord-015021-pol2qm74	2840	16	,	,	,
cord-015021-pol2qm74	2840	17	or	or	CC
cord-015021-pol2qm74	2840	18	unstimulated	unstimulated	JJ
cord-015021-pol2qm74	2840	19	,	,	,
cord-015021-pol2qm74	2840	20	also	also	RB
cord-015021-pol2qm74	2840	21	had	have	VBD
cord-015021-pol2qm74	2840	22	depressed	depress	VBN
cord-015021-pol2qm74	2840	23	IL-10	IL-10	NNP
cord-015021-pol2qm74	2840	24	production	production	NN
cord-015021-pol2qm74	2840	25	concomitant	concomitant	JJ
cord-015021-pol2qm74	2840	26	to	to	IN
cord-015021-pol2qm74	2840	27	elevated	elevated	JJ
cord-015021-pol2qm74	2840	28	TNFa	TNFa	NNS
cord-015021-pol2qm74	2840	29	production	production	NN
cord-015021-pol2qm74	2840	30	when	when	WRB
cord-015021-pol2qm74	2840	31	compared	compare	VBN
cord-015021-pol2qm74	2840	32	to	to	IN
cord-015021-pol2qm74	2840	33	normals	normal	NNS
cord-015021-pol2qm74	2840	34	'	'	POS
cord-015021-pol2qm74	2840	35	MO	MO	NNP
cord-015021-pol2qm74	2840	36	.	.	.
cord-015021-pol2qm74	2841	1	Mechanisms	mechanism	NNS
cord-015021-pol2qm74	2841	2	for	for	IN
cord-015021-pol2qm74	2841	3	the	the	DT
cord-015021-pol2qm74	2841	4	depressed	depressed	JJ
cord-015021-pol2qm74	2841	5	patients	patient	NNS
cord-015021-pol2qm74	2841	6	'	'	POS
cord-015021-pol2qm74	2841	7	MO	MO	NNP
cord-015021-pol2qm74	2841	8	IL-10	IL-10	NNP
cord-015021-pol2qm74	2841	9	were	be	VBD
cord-015021-pol2qm74	2841	10	explored	explore	VBN
cord-015021-pol2qm74	2841	11	.	.	.
cord-015021-pol2qm74	2842	1	Increases	increase	NNS
cord-015021-pol2qm74	2842	2	in	in	IN
cord-015021-pol2qm74	2842	3	TGF[3	TGF[3	NNP
cord-015021-pol2qm74	2842	4	may	may	MD
cord-015021-pol2qm74	2842	5	have	have	VB
cord-015021-pol2qm74	2842	6	partially	partially	RB
cord-015021-pol2qm74	2842	7	contributed	contribute	VBN
cord-015021-pol2qm74	2842	8	to	to	IN
cord-015021-pol2qm74	2842	9	the	the	DT
cord-015021-pol2qm74	2842	10	patients	patient	NNS
cord-015021-pol2qm74	2842	11	'	'	POS
cord-015021-pol2qm74	2842	12	depressed	depressed	JJ
cord-015021-pol2qm74	2842	13	IL-10	IL-10	NNP
cord-015021-pol2qm74	2842	14	level	level	NN
cord-015021-pol2qm74	2842	15	,	,	,
cord-015021-pol2qm74	2842	16	but	but	CC
cord-015021-pol2qm74	2842	17	elevated	elevated	JJ
cord-015021-pol2qm74	2842	18	PGE2	PGE2	NNP
cord-015021-pol2qm74	2842	19	had	have	VBD
cord-015021-pol2qm74	2842	20	no	no	DT
cord-015021-pol2qm74	2842	21	effect	effect	NN
cord-015021-pol2qm74	2842	22	.	.	.
cord-015021-pol2qm74	2843	1	Addition	addition	NN
cord-015021-pol2qm74	2843	2	of	of	IN
cord-015021-pol2qm74	2843	3	IL-12	IL-12	NNP
cord-015021-pol2qm74	2843	4	to	to	IN
cord-015021-pol2qm74	2843	5	patients	patient	NNS
cord-015021-pol2qm74	2843	6	'	'	POS
cord-015021-pol2qm74	2843	7	PBL	PBL	NNP
cord-015021-pol2qm74	2843	8	significantly	significantly	RB
cord-015021-pol2qm74	2843	9	increased	increase	VBD
cord-015021-pol2qm74	2843	10	their	-PRON-	PRP$
cord-015021-pol2qm74	2843	11	mitogen	mitogen	NN
cord-015021-pol2qm74	2843	12	responses	response	NNS
cord-015021-pol2qm74	2843	13	.	.	.
cord-015021-pol2qm74	2844	1	These	these	DT
cord-015021-pol2qm74	2844	2	data	datum	NNS
cord-015021-pol2qm74	2844	3	imply	imply	VBP
cord-015021-pol2qm74	2844	4	that	that	IN
cord-015021-pol2qm74	2844	5	SIS	SIS	NNP
cord-015021-pol2qm74	2844	6	is	be	VBZ
cord-015021-pol2qm74	2844	7	characterized	characterize	VBN
cord-015021-pol2qm74	2844	8	by	by	IN
cord-015021-pol2qm74	2844	9	disruption	disruption	NN
cord-015021-pol2qm74	2844	10	in	in	IN
cord-015021-pol2qm74	2844	11	the	the	DT
cord-015021-pol2qm74	2844	12	interactions	interaction	NNS
cord-015021-pol2qm74	2844	13	between	between	IN
cord-015021-pol2qm74	2844	14	MCi	MCi	NNS
cord-015021-pol2qm74	2844	15	and	and	CC
cord-015021-pol2qm74	2844	16	T	t	NN
cord-015021-pol2qm74	2844	17	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2844	18	so	so	IN
cord-015021-pol2qm74	2844	19	that	that	IN
cord-015021-pol2qm74	2844	20	patients	patient	NNS
cord-015021-pol2qm74	2844	21	'	'	POS
cord-015021-pol2qm74	2844	22	M	m	NN
cord-015021-pol2qm74	2845	1	~i	~i	NNP
cord-015021-pol2qm74	2845	2	produce	produce	VB
cord-015021-pol2qm74	2845	3	excesses	excess	NNS
cord-015021-pol2qm74	2845	4	of	of	IN
cord-015021-pol2qm74	2845	5	some	some	DT
cord-015021-pol2qm74	2845	6	mediators	mediator	NNS
cord-015021-pol2qm74	2845	7	(	(	-LRB-
cord-015021-pol2qm74	2845	8	TNFa	TNFa	NNP
cord-015021-pol2qm74	2845	9	,	,	,
cord-015021-pol2qm74	2845	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	2845	11	,	,	,
cord-015021-pol2qm74	2845	12	PGE2	PGE2	NNP
cord-015021-pol2qm74	2845	13	)	)	-RRB-
cord-015021-pol2qm74	2845	14	and	and	CC
cord-015021-pol2qm74	2845	15	a	a	DT
cord-015021-pol2qm74	2845	16	dearth	dearth	NN
cord-015021-pol2qm74	2845	17	of	of	IN
cord-015021-pol2qm74	2845	18	other	other	JJ
cord-015021-pol2qm74	2845	19	monokines	monokine	NNS
cord-015021-pol2qm74	2845	20	(	(	-LRB-
cord-015021-pol2qm74	2845	21	IL-12	IL-12	NNP
cord-015021-pol2qm74	2845	22	,	,	,
cord-015021-pol2qm74	2845	23	IL	IL	NNP
cord-015021-pol2qm74	2845	24	-	-	HYPH
cord-015021-pol2qm74	2845	25	IO	IO	NNP
cord-015021-pol2qm74	2845	26	)	)	-RRB-
cord-015021-pol2qm74	2845	27	.	.	.
cord-015021-pol2qm74	2846	1	T	T	NNP
cord-015021-pol2qm74	2846	2	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2846	3	are	be	VBP
cord-015021-pol2qm74	2846	4	not	not	RB
cord-015021-pol2qm74	2846	5	activated	activate	VBN
cord-015021-pol2qm74	2846	6	and	and	CC
cord-015021-pol2qm74	2846	7	,	,	,
cord-015021-pol2qm74	2846	8	therefore	therefore	RB
cord-015021-pol2qm74	2846	9	,	,	,
cord-015021-pol2qm74	2846	10	unable	unable	JJ
cord-015021-pol2qm74	2846	11	to	to	TO
cord-015021-pol2qm74	2846	12	function	function	VB
cord-015021-pol2qm74	2846	13	in	in	IN
cord-015021-pol2qm74	2846	14	both	both	DT
cord-015021-pol2qm74	2846	15	immune	immune	JJ
cord-015021-pol2qm74	2846	16	defense	defense	NN
cord-015021-pol2qm74	2846	17	and	and	CC
cord-015021-pol2qm74	2846	18	monocyte	monocyte	NNP
cord-015021-pol2qm74	2846	19	regulation	regulation	NN
cord-015021-pol2qm74	2846	20	.	.	.
cord-015021-pol2qm74	2847	1	It	-PRON-	PRP
cord-015021-pol2qm74	2847	2	is	be	VBZ
cord-015021-pol2qm74	2847	3	known	know	VBN
cord-015021-pol2qm74	2847	4	that	that	IN
cord-015021-pol2qm74	2847	5	lgE	lge	JJ
cord-015021-pol2qm74	2847	6	receptor	receptor	NN
cord-015021-pol2qm74	2847	7	-	-	HYPH
cord-015021-pol2qm74	2847	8	mediated	mediate	VBN
cord-015021-pol2qm74	2847	9	or	or	CC
cord-015021-pol2qm74	2847	10	Ca	Ca	NNP
cord-015021-pol2qm74	2847	11	-	-	HYPH
cord-015021-pol2qm74	2847	12	ionophore	ionophore	RB
cord-015021-pol2qm74	2847	13	-	-	HYPH
cord-015021-pol2qm74	2847	14	induced	induce	VBN
cord-015021-pol2qm74	2847	15	activation	activation	NN
cord-015021-pol2qm74	2847	16	of	of	IN
cord-015021-pol2qm74	2847	17	mouse	mouse	NN
cord-015021-pol2qm74	2847	18	bone	bone	NN
cord-015021-pol2qm74	2847	19	marrow	marrow	NN
cord-015021-pol2qm74	2847	20	-	-	HYPH
cord-015021-pol2qm74	2847	21	derived	derive	VBN
cord-015021-pol2qm74	2847	22	mast	mast	NN
cord-015021-pol2qm74	2847	23	cells	cell	NNS
cord-015021-pol2qm74	2847	24	(	(	-LRB-
cord-015021-pol2qm74	2847	25	13MMC	13mmc	CD
cord-015021-pol2qm74	2847	26	)	)	-RRB-
cord-015021-pol2qm74	2847	27	may	may	MD
cord-015021-pol2qm74	2847	28	result	result	VB
cord-015021-pol2qm74	2847	29	in	in	IN
cord-015021-pol2qm74	2847	30	the	the	DT
cord-015021-pol2qm74	2847	31	production	production	NN
cord-015021-pol2qm74	2847	32	of	of	IN
cord-015021-pol2qm74	2847	33	different	different	JJ
cord-015021-pol2qm74	2847	34	cytokines	cytokine	NNS
cord-015021-pol2qm74	2847	35	including	include	VBG
cord-015021-pol2qm74	2847	36	the	the	DT
cord-015021-pol2qm74	2847	37	interleukins	interleukin	NNS
cord-015021-pol2qm74	2847	38	(	(	-LRB-
cord-015021-pol2qm74	2847	39	IL	IL	NNP
cord-015021-pol2qm74	2847	40	)	)	-RRB-
cord-015021-pol2qm74	2847	41	3	3	CD
cord-015021-pol2qm74	2847	42	,	,	,
cord-015021-pol2qm74	2847	43	4	4	CD
cord-015021-pol2qm74	2847	44	,	,	,
cord-015021-pol2qm74	2847	45	5	5	CD
cord-015021-pol2qm74	2847	46	,	,	,
cord-015021-pol2qm74	2847	47	and	and	CC
cord-015021-pol2qm74	2847	48	6	6	CD
cord-015021-pol2qm74	2847	49	as	as	RB
cord-015021-pol2qm74	2847	50	well	well	RB
cord-015021-pol2qm74	2847	51	as	as	IN
cord-015021-pol2qm74	2847	52	GM	GM	NNP
cord-015021-pol2qm74	2847	53	-	-	HYPH
cord-015021-pol2qm74	2847	54	CSF	CSF	NNP
cord-015021-pol2qm74	2847	55	and	and	CC
cord-015021-pol2qm74	2847	56	TNF	TNF	NNP
cord-015021-pol2qm74	2847	57	-	-	HYPH
cord-015021-pol2qm74	2847	58	a	a	NNP
cord-015021-pol2qm74	2847	59	.	.	.
cord-015021-pol2qm74	2848	1	In	in	IN
cord-015021-pol2qm74	2848	2	the	the	DT
cord-015021-pol2qm74	2848	3	present	present	JJ
cord-015021-pol2qm74	2848	4	study	study	NN
cord-015021-pol2qm74	2848	5	we	-PRON-	PRP
cord-015021-pol2qm74	2848	6	analyzed	analyze	VBD
cord-015021-pol2qm74	2848	7	the	the	DT
cord-015021-pol2qm74	2848	8	effects	effect	NNS
cord-015021-pol2qm74	2848	9	of	of	IN
cord-015021-pol2qm74	2848	10	exogeneously	exogeneously	NN
cord-015021-pol2qm74	2848	11	applied	apply	VBN
cord-015021-pol2qm74	2848	12	pro	pro	JJ
cord-015021-pol2qm74	2848	13	-	-	JJ
cord-015021-pol2qm74	2848	14	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2848	15	cytokines	cytokine	NNS
cord-015021-pol2qm74	2848	16	(	(	-LRB-
cord-015021-pol2qm74	2848	17	IL-1	IL-1	NNP
cord-015021-pol2qm74	2848	18	,	,	,
cord-015021-pol2qm74	2848	19	1L-6	1l-6	CD
cord-015021-pol2qm74	2848	20	,	,	,
cord-015021-pol2qm74	2848	21	TNF	TNF	NNP
cord-015021-pol2qm74	2848	22	-	-	HYPH
cord-015021-pol2qm74	2848	23	c	c	NNP
cord-015021-pol2qm74	2848	24	0	0	NFP
cord-015021-pol2qm74	2848	25	as	as	RB
cord-015021-pol2qm74	2848	26	well	well	RB
cord-015021-pol2qm74	2848	27	as	as	IN
cord-015021-pol2qm74	2848	28	various	various	JJ
cord-015021-pol2qm74	2848	29	mast	mast	JJ
cord-015021-pol2qm74	2848	30	cell	cell	NN
cord-015021-pol2qm74	2848	31	growth	growth	NN
cord-015021-pol2qm74	2848	32	factors	factor	NNS
cord-015021-pol2qm74	2848	33	(	(	-LRB-
cord-015021-pol2qm74	2848	34	IL-3	IL-3	NNP
cord-015021-pol2qm74	2848	35	,	,	,
cord-015021-pol2qm74	2848	36	IL-4	IL-4	NNP
cord-015021-pol2qm74	2848	37	,	,	,
cord-015021-pol2qm74	2848	38	IL-9	IL-9	NNP
cord-015021-pol2qm74	2848	39	,	,	,
cord-015021-pol2qm74	2848	40	IL-10	IL-10	NNP
cord-015021-pol2qm74	2848	41	,	,	,
cord-015021-pol2qm74	2848	42	NGF	NGF	NNP
cord-015021-pol2qm74	2848	43	,	,	,
cord-015021-pol2qm74	2848	44	KL	KL	NNP
cord-015021-pol2qm74	2848	45	(	(	-LRB-
cord-015021-pol2qm74	2848	46	kit	kit	NN
cord-015021-pol2qm74	2848	47	ligand	ligand	NN
cord-015021-pol2qm74	2848	48	)	)	-RRB-
cord-015021-pol2qm74	2848	49	)	)	-RRB-
cord-015021-pol2qm74	2848	50	on	on	IN
cord-015021-pol2qm74	2848	51	cytokine	cytokine	NN
cord-015021-pol2qm74	2848	52	production	production	NN
cord-015021-pol2qm74	2848	53	in	in	IN
cord-015021-pol2qm74	2848	54	primary	primary	JJ
cord-015021-pol2qm74	2848	55	mouse	mouse	NN
cord-015021-pol2qm74	2848	56	BMMC	BMMC	NNP
cord-015021-pol2qm74	2848	57	using	use	VBG
cord-015021-pol2qm74	2848	58	a	a	DT
cord-015021-pol2qm74	2848	59	standard	standard	JJ
cord-015021-pol2qm74	2848	60	activation	activation	NN
cord-015021-pol2qm74	2848	61	protocol	protocol	NN
cord-015021-pol2qm74	2848	62	(	(	-LRB-
cord-015021-pol2qm74	2848	63	lxl06	lxl06	NNP
cord-015021-pol2qm74	2848	64	BMMC	BMMC	NNP
cord-015021-pol2qm74	2848	65	/	/	SYM
cord-015021-pol2qm74	2848	66	ml	ml	XX
cord-015021-pol2qm74	2848	67	;	;	:
cord-015021-pol2qm74	2848	68	ll.uM	ll.um	ADD
cord-015021-pol2qm74	2848	69	ionomycin	ionomycin	NNS
cord-015021-pol2qm74	2848	70	;	;	:
cord-015021-pol2qm74	2848	71	24	24	CD
cord-015021-pol2qm74	2848	72	-	-	HYPH
cord-015021-pol2qm74	2848	73	48h	48h	CD
cord-015021-pol2qm74	2848	74	)	)	-RRB-
cord-015021-pol2qm74	2848	75	.	.	.
cord-015021-pol2qm74	2849	1	The	the	DT
cord-015021-pol2qm74	2849	2	actixdties	actixdtie	NNS
cord-015021-pol2qm74	2849	3	of	of	IN
cord-015021-pol2qm74	2849	4	BMMC	BMMC	NNP
cord-015021-pol2qm74	2849	5	supernatants	supernatant	NNS
cord-015021-pol2qm74	2849	6	were	be	VBD
cord-015021-pol2qm74	2849	7	assessed	assess	VBN
cord-015021-pol2qm74	2849	8	in	in	IN
cord-015021-pol2qm74	2849	9	specific	specific	JJ
cord-015021-pol2qm74	2849	10	biological	biological	JJ
cord-015021-pol2qm74	2849	11	(	(	-LRB-
cord-015021-pol2qm74	2849	12	IL-3	IL-3	NNP
cord-015021-pol2qm74	2849	13	,	,	,
cord-015021-pol2qm74	2849	14	IL-4	IL-4	NNP
cord-015021-pol2qm74	2849	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	2849	16	,	,	,
cord-015021-pol2qm74	2849	17	1L-9	1l-9	CD
cord-015021-pol2qm74	2849	18	)	)	-RRB-
cord-015021-pol2qm74	2850	1	and/or	and/or	CC
cord-015021-pol2qm74	2851	1	ELISA	ELISA	NNP
cord-015021-pol2qm74	2851	2	assays	assay	NNS
cord-015021-pol2qm74	2851	3	(	(	-LRB-
cord-015021-pol2qm74	2851	4	IL-5	IL-5	NNP
cord-015021-pol2qm74	2851	5	,	,	,
cord-015021-pol2qm74	2851	6	IL-9	IL-9	NNP
cord-015021-pol2qm74	2851	7	)	)	-RRB-
cord-015021-pol2qm74	2851	8	.	.	.
cord-015021-pol2qm74	2852	1	Here	here	RB
cord-015021-pol2qm74	2852	2	we	-PRON-	PRP
cord-015021-pol2qm74	2852	3	show	show	VBP
cord-015021-pol2qm74	2852	4	that	that	IN
cord-015021-pol2qm74	2852	5	homogeneous	homogeneous	JJ
cord-015021-pol2qm74	2852	6	populations	population	NNS
cord-015021-pol2qm74	2852	7	of	of	IN
cord-015021-pol2qm74	2852	8	BMMC	BMMC	NNP
cord-015021-pol2qm74	2853	1	(	(	-LRB-
cord-015021-pol2qm74	2853	2	>	>	NFP
cord-015021-pol2qm74	2853	3	97%Alcian	97%alcian	CD
cord-015021-pol2qm74	2853	4	blue+/Safranln-	blue+/Safranln-	NNP
cord-015021-pol2qm74	2853	5	;	;	:
cord-015021-pol2qm74	2853	6	in	in	IN
cord-015021-pol2qm74	2853	7	vitro	vitro	FW
cord-015021-pol2qm74	2853	8	age	age	NN
cord-015021-pol2qm74	2853	9	:	:	:
cord-015021-pol2qm74	2853	10	4	4	CD
cord-015021-pol2qm74	2853	11	weeks	week	NNS
cord-015021-pol2qm74	2853	12	)	)	-RRB-
cord-015021-pol2qm74	2853	13	generated	generate	VBN
cord-015021-pol2qm74	2853	14	in	in	IN
cord-015021-pol2qm74	2853	15	the	the	DT
cord-015021-pol2qm74	2853	16	presence	presence	NN
cord-015021-pol2qm74	2853	17	of	of	IN
cord-015021-pol2qm74	2853	18	recombinant	recombinant	JJ
cord-015021-pol2qm74	2853	19	(	(	-LRB-
cord-015021-pol2qm74	2853	20	r	r	NN
cord-015021-pol2qm74	2853	21	)	)	-RRB-
cord-015021-pol2qm74	2853	22	raiL-3	rail-3	XX
cord-015021-pol2qm74	2853	23	from	from	IN
cord-015021-pol2qm74	2853	24	normal	normal	JJ
cord-015021-pol2qm74	2853	25	BALB	BALB	NNP
cord-015021-pol2qm74	2853	26	/	/	SYM
cord-015021-pol2qm74	2853	27	c	c	NN
cord-015021-pol2qm74	2853	28	mice	mouse	NNS
cord-015021-pol2qm74	2853	29	produced	produce	VBD
cord-015021-pol2qm74	2853	30	modest	modest	JJ
cord-015021-pol2qm74	2853	31	amounts	amount	NNS
cord-015021-pol2qm74	2853	32	of	of	IN
cord-015021-pol2qm74	2853	33	1L-6	1l-6	CD
cord-015021-pol2qm74	2853	34	and	and	CC
cord-015021-pol2qm74	2853	35	low	low	JJ
cord-015021-pol2qm74	2853	36	or	or	CC
cord-015021-pol2qm74	2853	37	undetectable	undetectable	JJ
cord-015021-pol2qm74	2853	38	levels	level	NNS
cord-015021-pol2qm74	2853	39	of	of	IN
cord-015021-pol2qm74	2853	40	IL-3	IL-3	NNP
cord-015021-pol2qm74	2853	41	,	,	,
cord-015021-pol2qm74	2853	42	-5	-5	NNP
cord-015021-pol2qm74	2853	43	,	,	,
cord-015021-pol2qm74	2853	44	and	and	CC
cord-015021-pol2qm74	2853	45	-9	-9	NN
cord-015021-pol2qm74	2853	46	after	after	IN
cord-015021-pol2qm74	2853	47	induction	induction	NN
cord-015021-pol2qm74	2853	48	with	with	IN
cord-015021-pol2qm74	2853	49	lp	lp	NNP
cord-015021-pol2qm74	2853	50	.	.	.
cord-015021-pol2qm74	2854	1	M	M	NNP
cord-015021-pol2qm74	2854	2	ionomycin	ionomycin	VBZ
cord-015021-pol2qm74	2854	3	only	only	RB
cord-015021-pol2qm74	2854	4	.	.	.
cord-015021-pol2qm74	2855	1	However	however	RB
cord-015021-pol2qm74	2855	2	,	,	,
cord-015021-pol2qm74	2855	3	a	a	DT
cord-015021-pol2qm74	2855	4	dramatic	dramatic	JJ
cord-015021-pol2qm74	2855	5	increase	increase	NN
cord-015021-pol2qm74	2855	6	(	(	-LRB-
cord-015021-pol2qm74	2855	7	5-to	5-to	CD
cord-015021-pol2qm74	2855	8	10-fold	10-fold	CD
cord-015021-pol2qm74	2855	9	)	)	-RRB-
cord-015021-pol2qm74	2855	10	of	of	IN
cord-015021-pol2qm74	2855	11	these	these	DT
cord-015021-pol2qm74	2855	12	cytokine	cytokine	NN
cord-015021-pol2qm74	2855	13	activities	activity	NNS
cord-015021-pol2qm74	2855	14	was	be	VBD
cord-015021-pol2qm74	2855	15	noted	note	VBN
cord-015021-pol2qm74	2855	16	,	,	,
cord-015021-pol2qm74	2855	17	when	when	WRB
cord-015021-pol2qm74	2855	18	in	in	IN
cord-015021-pol2qm74	2855	19	addition	addition	NN
cord-015021-pol2qm74	2855	20	to	to	IN
cord-015021-pol2qm74	2855	21	ionomycin	ionomycin	NNP
cord-015021-pol2qm74	2855	22	also	also	RB
cord-015021-pol2qm74	2855	23	human	human	JJ
cord-015021-pol2qm74	2855	24	(	(	-LRB-
cord-015021-pol2qm74	2855	25	11	11	CD
cord-015021-pol2qm74	2855	26	)	)	-RRB-
cord-015021-pol2qm74	2855	27	rlL	rlL	NNS
cord-015021-pol2qm74	2855	28	-	-	:
cord-015021-pol2qm74	2855	29	la	la	NNP
cord-015021-pol2qm74	2855	30	was	be	VBD
cord-015021-pol2qm74	2855	31	provided	provide	VBN
cord-015021-pol2qm74	2855	32	during	during	IN
cord-015021-pol2qm74	2855	33	the	the	DT
cord-015021-pol2qm74	2855	34	induction	induction	NN
cord-015021-pol2qm74	2855	35	period	period	NN
cord-015021-pol2qm74	2855	36	.	.	.
cord-015021-pol2qm74	2856	1	This	this	DT
cord-015021-pol2qm74	2856	2	IL-1	IL-1	NNP
cord-015021-pol2qm74	2856	3	effect	effect	NN
cord-015021-pol2qm74	2856	4	was	be	VBD
cord-015021-pol2qm74	2856	5	dose	dose	JJ
cord-015021-pol2qm74	2856	6	dependent	dependent	JJ
cord-015021-pol2qm74	2856	7	with	with	IN
cord-015021-pol2qm74	2856	8	a	a	DT
cord-015021-pol2qm74	2856	9	maximgm	maximgm	NN
cord-015021-pol2qm74	2856	10	at	at	IN
cord-015021-pol2qm74	2856	11	2	2	CD
cord-015021-pol2qm74	2856	12	-	-	SYM
cord-015021-pol2qm74	2856	13	10	10	CD
cord-015021-pol2qm74	2856	14	U	U	NNP
cord-015021-pol2qm74	2856	15	/	/	SYM
cord-015021-pol2qm74	2856	16	ml	ml	NNS
cord-015021-pol2qm74	2856	17	hrlL	hrlL	NNP
cord-015021-pol2qm74	2856	18	-	-	HYPH
cord-015021-pol2qm74	2856	19	la	la	NN
cord-015021-pol2qm74	2856	20	and	and	CC
cord-015021-pol2qm74	2856	21	specific	specific	JJ
cord-015021-pol2qm74	2856	22	,	,	,
cord-015021-pol2qm74	2856	23	as	as	IN
cord-015021-pol2qm74	2856	24	pre	pre	JJ
cord-015021-pol2qm74	2856	25	-	-	NN
cord-015021-pol2qm74	2856	26	incubation	incubation	JJ
cord-015021-pol2qm74	2856	27	(	(	-LRB-
cord-015021-pol2qm74	2856	28	lh	lh	NNP
cord-015021-pol2qm74	2856	29	)	)	-RRB-
cord-015021-pol2qm74	2856	30	of	of	IN
cord-015021-pol2qm74	2856	31	BMMC	BMMC	NNP
cord-015021-pol2qm74	2857	1	with	with	IN
cord-015021-pol2qm74	2857	2	20	20	CD
cord-015021-pol2qm74	2857	3	ng	ng	NN
cord-015021-pol2qm74	2857	4	/	/	SYM
cord-015021-pol2qm74	2857	5	ml	ml	NN
cord-015021-pol2qm74	2858	1	hrlL-1	hrlL-1	NNP
cord-015021-pol2qm74	2858	2	receptor	receptor	NN
cord-015021-pol2qm74	2858	3	antagonist	antagonist	NN
cord-015021-pol2qm74	2858	4	abolished	abolish	VBD
cord-015021-pol2qm74	2858	5	the	the	DT
cord-015021-pol2qm74	2858	6	action	action	NN
cord-015021-pol2qm74	2858	7	of	of	IN
cord-015021-pol2qm74	2858	8	2	2	CD
cord-015021-pol2qm74	2858	9	U	U	NNP
cord-015021-pol2qm74	2858	10	/	/	SYM
cord-015021-pol2qm74	2858	11	ml	ml	IN
cord-015021-pol2qm74	2858	12	hrlL	hrlL	NNP
cord-015021-pol2qm74	2858	13	-	-	HYPH
cord-015021-pol2qm74	2858	14	lcc	lcc	NNP
cord-015021-pol2qm74	2858	15	Similar	similar	JJ
cord-015021-pol2qm74	2858	16	effects	effect	NNS
cord-015021-pol2qm74	2858	17	were	be	VBD
cord-015021-pol2qm74	2858	18	noted	note	VBN
cord-015021-pol2qm74	2858	19	with	with	IN
cord-015021-pol2qm74	2858	20	hrlL	hrlL	NNS
cord-015021-pol2qm74	2858	21	-	-	HYPH
cord-015021-pol2qm74	2858	22	lg	lg	NN
cord-015021-pol2qm74	2858	23	or	or	CC
cord-015021-pol2qm74	2858	24	rurlL	rurlL	NNP
cord-015021-pol2qm74	2858	25	-	-	HYPH
cord-015021-pol2qm74	2858	26	lB	lb	NN
cord-015021-pol2qm74	2859	1	(	(	-LRB-
cord-015021-pol2qm74	2859	2	lng	lng	NNP
cord-015021-pol2qm74	2859	3	/	/	SYM
cord-015021-pol2qm74	2859	4	ml	ml	NNP
cord-015021-pol2qm74	2859	5	,	,	,
cord-015021-pol2qm74	2859	6	respectively	respectively	RB
cord-015021-pol2qm74	2859	7	)	)	-RRB-
cord-015021-pol2qm74	2859	8	,	,	,
cord-015021-pol2qm74	2859	9	but	but	CC
cord-015021-pol2qm74	2859	10	not	not	RB
cord-015021-pol2qm74	2859	11	with	with	IN
cord-015021-pol2qm74	2859	12	rhlL-6	rhll-6	CD
cord-015021-pol2qm74	2859	13	or	or	CC
cord-015021-pol2qm74	2859	14	rmTNF-~.	rmtnf-~.	NN
cord-015021-pol2qm74	2860	1	Both	both	DT
cord-015021-pol2qm74	2860	2	mrlL-10	mrlL-10	NNP
cord-015021-pol2qm74	2860	3	and	and	CC
cord-015021-pol2qm74	2860	4	hrlL-10	hrlL-10	NNP
cord-015021-pol2qm74	2860	5	substantially	substantially	RB
cord-015021-pol2qm74	2860	6	enhanced	enhance	VBN
cord-015021-pol2qm74	2860	7	ionomycin	ionomycin	NN
cord-015021-pol2qm74	2860	8	-	-	HYPH
cord-015021-pol2qm74	2860	9	induced	induce	VBN
cord-015021-pol2qm74	2860	10	1L-6	1l-6	CD
cord-015021-pol2qm74	2860	11	production	production	NN
cord-015021-pol2qm74	2860	12	of	of	IN
cord-015021-pol2qm74	2860	13	BMMC	BMMC	NNP
cord-015021-pol2qm74	2860	14	in	in	IN
cord-015021-pol2qm74	2860	15	the	the	DT
cord-015021-pol2qm74	2860	16	absence	absence	NN
cord-015021-pol2qm74	2860	17	or	or	CC
cord-015021-pol2qm74	2860	18	presence	presence	NN
cord-015021-pol2qm74	2860	19	of	of	IN
cord-015021-pol2qm74	2860	20	IL-1	IL-1	NNP
cord-015021-pol2qm74	2860	21	.	.	.
cord-015021-pol2qm74	2860	22	IL-10	IL-10	NNP
cord-015021-pol2qm74	2860	23	significantly	significantly	RB
cord-015021-pol2qm74	2860	24	enhanced	enhance	VBD
cord-015021-pol2qm74	2860	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	2860	26	and	and	CC
cord-015021-pol2qm74	2860	27	IL-9	IL-9	NNP
cord-015021-pol2qm74	2860	28	production	production	NN
cord-015021-pol2qm74	2860	29	while	while	IN
cord-015021-pol2qm74	2860	30	decreasing	decrease	VBG
cord-015021-pol2qm74	2860	31	IL-3	IL-3	NNP
cord-015021-pol2qm74	2860	32	activities	activity	NNS
cord-015021-pol2qm74	2860	33	to	to	TO
cord-015021-pol2qm74	2860	34	abont	abont	VB
cord-015021-pol2qm74	2860	35	50	50	CD
cord-015021-pol2qm74	2860	36	-	-	SYM
cord-015021-pol2qm74	2860	37	90	90	CD
cord-015021-pol2qm74	2860	38	%	%	NN
cord-015021-pol2qm74	2860	39	of	of	IN
cord-015021-pol2qm74	2860	40	control	control	NN
cord-015021-pol2qm74	2860	41	levels	level	NNS
cord-015021-pol2qm74	2860	42	,	,	,
cord-015021-pol2qm74	2860	43	when	when	WRB
cord-015021-pol2qm74	2860	44	IL	IL	NNP
cord-015021-pol2qm74	2860	45	-	-	HYPH
cord-015021-pol2qm74	2860	46	I0	I0	NNP
cord-015021-pol2qm74	2860	47	was	be	VBD
cord-015021-pol2qm74	2860	48	provided	provide	VBN
cord-015021-pol2qm74	2860	49	in	in	IN
cord-015021-pol2qm74	2860	50	the	the	DT
cord-015021-pol2qm74	2860	51	presence	presence	NN
cord-015021-pol2qm74	2860	52	of	of	IN
cord-015021-pol2qm74	2860	53	IL	IL	NNP
cord-015021-pol2qm74	2860	54	-	-	HYPH
cord-015021-pol2qm74	2860	55	l	l	NNP
cord-015021-pol2qm74	2860	56	/	/	SYM
cord-015021-pol2qm74	2860	57	ionomycin	ionomycin	NNS
cord-015021-pol2qm74	2860	58	.	.	.
cord-015021-pol2qm74	2861	1	A	a	DT
cord-015021-pol2qm74	2861	2	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	2861	3	anti	anti	JJ
cord-015021-pol2qm74	2861	4	-	-	JJ
cord-015021-pol2qm74	2861	5	nfiL	nfil	JJ
cord-015021-pol2qm74	2861	6	-	-	HYPH
cord-015021-pol2qm74	2861	7	t0	t0	NNP
cord-015021-pol2qm74	2861	8	antibody	antibody	NN
cord-015021-pol2qm74	2861	9	(	(	-LRB-
cord-015021-pol2qm74	2861	10	ascites	ascite	NNS
cord-015021-pol2qm74	2861	11	1:200	1:200	CD
cord-015021-pol2qm74	2861	12	)	)	-RRB-
cord-015021-pol2qm74	2861	13	abrogated	abrogate	VBD
cord-015021-pol2qm74	2861	14	the	the	DT
cord-015021-pol2qm74	2861	15	effects	effect	NNS
cord-015021-pol2qm74	2861	16	of	of	IN
cord-015021-pol2qm74	2861	17	mrlL-10	mrlL-10	NNP
cord-015021-pol2qm74	2861	18	.	.	.
cord-015021-pol2qm74	2862	1	Other	other	JJ
cord-015021-pol2qm74	2862	2	mast	mast	JJ
cord-015021-pol2qm74	2862	3	cell	cell	NN
cord-015021-pol2qm74	2862	4	-	-	HYPH
cord-015021-pol2qm74	2862	5	active	active	JJ
cord-015021-pol2qm74	2862	6	cy	cy	NNP
cord-015021-pol2qm74	2862	7	~	~	CD
cord-015021-pol2qm74	2862	8	okines	okines	NNP
cord-015021-pol2qm74	2862	9	(	(	-LRB-
cord-015021-pol2qm74	2862	10	]	]	-RRB-
cord-015021-pol2qm74	2862	11	1,-3	1,-3	NNP
cord-015021-pol2qm74	2862	12	,	,	,
cord-015021-pol2qm74	2862	13	IL-4	IL-4	NNP
cord-015021-pol2qm74	2862	14	,	,	,
cord-015021-pol2qm74	2862	15	1L-9	1l-9	CD
cord-015021-pol2qm74	2862	16	,	,	,
cord-015021-pol2qm74	2862	17	NGF	NGF	NNP
cord-015021-pol2qm74	2862	18	,	,	,
cord-015021-pol2qm74	2862	19	or	or	CC
cord-015021-pol2qm74	2862	20	KL	KL	NNP
cord-015021-pol2qm74	2862	21	)	)	-RRB-
cord-015021-pol2qm74	2862	22	added	add	VBD
cord-015021-pol2qm74	2862	23	to	to	IN
cord-015021-pol2qm74	2862	24	ionomycia	ionomycia	NNP
cord-015021-pol2qm74	2862	25	-	-	,
cord-015021-pol2qm74	2862	26	or	or	CC
cord-015021-pol2qm74	2862	27	1L-1	1l-1	CD
cord-015021-pol2qm74	2862	28	/	/	SYM
cord-015021-pol2qm74	2862	29	ionomycin	ionomycin	NNS
cord-015021-pol2qm74	2862	30	-	-	HYPH
cord-015021-pol2qm74	2862	31	treated	treat	VBN
cord-015021-pol2qm74	2862	32	BMMC	BMMC	NNP
cord-015021-pol2qm74	2862	33	had	have	VBD
cord-015021-pol2qm74	2862	34	no	no	DT
cord-015021-pol2qm74	2862	35	major	major	JJ
cord-015021-pol2qm74	2862	36	effects	effect	NNS
cord-015021-pol2qm74	2862	37	on	on	IN
cord-015021-pol2qm74	2862	38	cytokine	cytokine	NN
cord-015021-pol2qm74	2862	39	production	production	NN
cord-015021-pol2qm74	2862	40	.	.	.
cord-015021-pol2qm74	2863	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	2863	2	and	and	CC
cord-015021-pol2qm74	2863	3	IL	IL	NNP
cord-015021-pol2qm74	2863	4	-	-	HYPH
cord-015021-pol2qm74	2863	5	I0	I0	NNP
cord-015021-pol2qm74	2863	6	did	do	VBD
cord-015021-pol2qm74	2863	7	not	not	RB
cord-015021-pol2qm74	2863	8	induce	induce	VB
cord-015021-pol2qm74	2863	9	significant	significant	JJ
cord-015021-pol2qm74	2863	10	cytokine	cytokine	NN
cord-015021-pol2qm74	2863	11	release	release	NN
cord-015021-pol2qm74	2863	12	in	in	IN
cord-015021-pol2qm74	2863	13	the	the	DT
cord-015021-pol2qm74	2863	14	absence	absence	NN
cord-015021-pol2qm74	2863	15	of	of	IN
cord-015021-pol2qm74	2863	16	ionomycin	ionomycin	NNS
cord-015021-pol2qm74	2863	17	suggesting	suggest	VBG
cord-015021-pol2qm74	2863	18	tlmt	tlmt	IN
cord-015021-pol2qm74	2863	19	Cadependent	Cadependent	NNP
cord-015021-pol2qm74	2863	20	signalling	signalling	NN
cord-015021-pol2qm74	2863	21	was	be	VBD
cord-015021-pol2qm74	2863	22	required	require	VBN
cord-015021-pol2qm74	2863	23	.	.	.
cord-015021-pol2qm74	2864	1	At	at	IN
cord-015021-pol2qm74	2864	2	doses	dose	NNS
cord-015021-pol2qm74	2864	3	of	of	IN
cord-015021-pol2qm74	2864	4	10"6	10"6	CD
cord-015021-pol2qm74	2864	5	M	M	NNP
cord-015021-pol2qm74	2864	6	,	,	,
cord-015021-pol2qm74	2864	7	dexamethasone	dexamethasone	NN
cord-015021-pol2qm74	2864	8	,	,	,
cord-015021-pol2qm74	2864	9	corticosterone	corticosterone	NN
cord-015021-pol2qm74	2864	10	,	,	,
cord-015021-pol2qm74	2864	11	or	or	CC
cord-015021-pol2qm74	2864	12	hydrocortisone	hydrocortisone	NN
cord-015021-pol2qm74	2864	13	almost	almost	RB
cord-015021-pol2qm74	2864	14	completely	completely	RB
cord-015021-pol2qm74	2864	15	abolished	abolish	VBN
cord-015021-pol2qm74	2864	16	ionomycin	ionomycin	NNS
cord-015021-pol2qm74	2864	17	/	/	SYM
cord-015021-pol2qm74	2864	18	IL-1	IL-1	NNP
cord-015021-pol2qm74	2864	19	/	/	SYM
cord-015021-pol2qm74	2864	20	lL-10induced	ll-10induced	CD
cord-015021-pol2qm74	2864	21	cytokine	cytokine	NN
cord-015021-pol2qm74	2864	22	production	production	NN
cord-015021-pol2qm74	2864	23	.	.	.
cord-015021-pol2qm74	2865	1	The	the	DT
cord-015021-pol2qm74	2865	2	inducer	inducer	NN
cord-015021-pol2qm74	2865	3	cocktails	cocktail	NNS
cord-015021-pol2qm74	2865	4	per	per	FW
cord-015021-pol2qm74	2865	5	se	se	FW
cord-015021-pol2qm74	2865	6	did	do	VBD
cord-015021-pol2qm74	2865	7	not	not	RB
cord-015021-pol2qm74	2865	8	interfere	interfere	VB
cord-015021-pol2qm74	2865	9	with	with	IN
cord-015021-pol2qm74	2865	10	the	the	DT
cord-015021-pol2qm74	2865	11	cytokine	cytokine	NN
cord-015021-pol2qm74	2865	12	bio	bio	NN
cord-015021-pol2qm74	2865	13	-	-	HYPH
cord-015021-pol2qm74	2865	14	assays	assay	NNS
cord-015021-pol2qm74	2865	15	.	.	.
cord-015021-pol2qm74	2866	1	In	in	IN
cord-015021-pol2qm74	2866	2	case	case	NN
cord-015021-pol2qm74	2866	3	of	of	IN
cord-015021-pol2qm74	2866	4	IL-9	IL-9	NNP
cord-015021-pol2qm74	2866	5	inducibility	inducibility	NN
cord-015021-pol2qm74	2866	6	of	of	IN
cord-015021-pol2qm74	2866	7	this	this	DT
cord-015021-pol2qm74	2866	8	cytokine	cytokine	NN
cord-015021-pol2qm74	2866	9	in	in	IN
cord-015021-pol2qm74	2866	10	BMMC	BMMC	NNP
cord-015021-pol2qm74	2866	11	was	be	VBD
cord-015021-pol2qm74	2866	12	confirmed	confirm	VBN
cord-015021-pol2qm74	2866	13	at	at	IN
cord-015021-pol2qm74	2866	14	the	the	DT
cord-015021-pol2qm74	2866	15	mRNA	mRNA	NNP
cord-015021-pol2qm74	2866	16	level	level	NN
cord-015021-pol2qm74	2866	17	by	by	IN
cord-015021-pol2qm74	2866	18	Northern	northern	JJ
cord-015021-pol2qm74	2866	19	blot	blot	NN
cord-015021-pol2qm74	2866	20	analysis	analysis	NN
cord-015021-pol2qm74	2866	21	.	.	.
cord-015021-pol2qm74	2867	1	Hence	hence	RB
cord-015021-pol2qm74	2867	2	our	-PRON-	PRP$
cord-015021-pol2qm74	2867	3	data	datum	NNS
cord-015021-pol2qm74	2867	4	show	show	VBP
cord-015021-pol2qm74	2867	5	that	that	IN
cord-015021-pol2qm74	2867	6	activated	activate	VBN
cord-015021-pol2qm74	2867	7	mast	mast	NN
cord-015021-pol2qm74	2867	8	cells	cell	NNS
cord-015021-pol2qm74	2867	9	are	be	VBP
cord-015021-pol2qm74	2867	10	a	a	DT
cord-015021-pol2qm74	2867	11	source	source	NN
cord-015021-pol2qm74	2867	12	of	of	IN
cord-015021-pol2qm74	2867	13	IL-9	IL-9	NNP
cord-015021-pol2qm74	2867	14	previously	previously	RB
cord-015021-pol2qm74	2867	15	recognized	recognize	VBD
cord-015021-pol2qm74	2867	16	as	as	IN
cord-015021-pol2qm74	2867	17	a	a	DT
cord-015021-pol2qm74	2867	18	product	product	NN
cord-015021-pol2qm74	2867	19	of	of	IN
cord-015021-pol2qm74	2867	20	TH2type	TH2type	NNP
cord-015021-pol2qm74	2867	21	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2867	22	only	only	RB
cord-015021-pol2qm74	2867	23	.	.	.
cord-015021-pol2qm74	2868	1	Moreover	moreover	RB
cord-015021-pol2qm74	2868	2	,	,	,
cord-015021-pol2qm74	2868	3	our	-PRON-	PRP$
cord-015021-pol2qm74	2868	4	study	study	NN
cord-015021-pol2qm74	2868	5	reveals	reveal	VBZ
cord-015021-pol2qm74	2868	6	novel	novel	JJ
cord-015021-pol2qm74	2868	7	functional	functional	JJ
cord-015021-pol2qm74	2868	8	roles	role	NNS
cord-015021-pol2qm74	2868	9	for	for	IN
cord-015021-pol2qm74	2868	10	I	I	NNP
cord-015021-pol2qm74	2868	11	-	-	HYPH
cord-015021-pol2qm74	2868	12	L	l	NN
cord-015021-pol2qm74	2868	13	-	-	:
cord-015021-pol2qm74	2868	14	I	I	NNP
cord-015021-pol2qm74	2868	15	,	,	,
cord-015021-pol2qm74	2868	16	IL-10	IL-10	NNP
cord-015021-pol2qm74	2868	17	,	,	,
cord-015021-pol2qm74	2868	18	and	and	CC
cord-015021-pol2qm74	2868	19	ghicecorticoids	ghicecorticoid	NNS
cord-015021-pol2qm74	2868	20	in	in	IN
cord-015021-pol2qm74	2868	21	the	the	DT
cord-015021-pol2qm74	2868	22	regulation	regulation	NN
cord-015021-pol2qm74	2868	23	of	of	IN
cord-015021-pol2qm74	2868	24	cytoldne	cytoldne	NNP
cord-015021-pol2qm74	2868	25	production	production	NN
cord-015021-pol2qm74	2868	26	in	in	IN
cord-015021-pol2qm74	2868	27	mast	mast	JJ
cord-015021-pol2qm74	2868	28	ceils	ceil	NNS
cord-015021-pol2qm74	2868	29	.	.	.
cord-015021-pol2qm74	2869	1	Accumulating	accumulate	VBG
cord-015021-pol2qm74	2869	2	data	datum	NNS
cord-015021-pol2qm74	2869	3	suggests	suggest	VBZ
cord-015021-pol2qm74	2869	4	that	that	IN
cord-015021-pol2qm74	2869	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	2869	6	,	,	,
cord-015021-pol2qm74	2869	7	peptides	peptide	NNS
cord-015021-pol2qm74	2869	8	involved	involve	VBN
cord-015021-pol2qm74	2869	9	in	in	IN
cord-015021-pol2qm74	2869	10	regulation	regulation	NN
cord-015021-pol2qm74	2869	11	of	of	IN
cord-015021-pol2qm74	2869	12	both	both	DT
cord-015021-pol2qm74	2869	13	physiological	physiological	JJ
cord-015021-pol2qm74	2869	14	and	and	CC
cord-015021-pol2qm74	2869	15	pathological	pathological	JJ
cord-015021-pol2qm74	2869	16	immunological	immunological	JJ
cord-015021-pol2qm74	2869	17	responses	response	NNS
cord-015021-pol2qm74	2869	18	,	,	,
cord-015021-pol2qm74	2869	19	predominantly	predominantly	RB
cord-015021-pol2qm74	2869	20	are	be	VBP
cord-015021-pol2qm74	2869	21	produced	produce	VBN
cord-015021-pol2qm74	2869	22	at	at	IN
cord-015021-pol2qm74	2869	23	the	the	DT
cord-015021-pol2qm74	2869	24	local	local	JJ
cord-015021-pol2qm74	2869	25	site	site	NN
cord-015021-pol2qm74	2869	26	of	of	IN
cord-015021-pol2qm74	2869	27	antigen	antigen	NN
cord-015021-pol2qm74	2869	28	stimulation	stimulation	NN
cord-015021-pol2qm74	2869	29	.	.	.
cord-015021-pol2qm74	2870	1	A	a	DT
cord-015021-pol2qm74	2870	2	new	new	JJ
cord-015021-pol2qm74	2870	3	method	method	NN
cord-015021-pol2qm74	2870	4	was	be	VBD
cord-015021-pol2qm74	2870	5	used	use	VBN
cord-015021-pol2qm74	2870	6	to	to	TO
cord-015021-pol2qm74	2870	7	detect	detect	VB
cord-015021-pol2qm74	2870	8	cytokine	cytokine	NN
cord-015021-pol2qm74	2870	9	-	-	HYPH
cord-015021-pol2qm74	2870	10	producing	produce	VBG
cord-015021-pol2qm74	2870	11	cells	cell	NNS
cord-015021-pol2qm74	2870	12	in	in	IN
cord-015021-pol2qm74	2870	13	haman	haman	NNP
cord-015021-pol2qm74	2870	14	tissue	tissue	NN
cord-015021-pol2qm74	2870	15	at	at	IN
cord-015021-pol2qm74	2870	16	the	the	DT
cord-015021-pol2qm74	2870	17	protein	protein	NN
cord-015021-pol2qm74	2870	18	level	level	NN
cord-015021-pol2qm74	2870	19	.	.	.
cord-015021-pol2qm74	2871	1	Single	single	JJ
cord-015021-pol2qm74	2871	2	-	-	HYPH
cord-015021-pol2qm74	2871	3	cell	cell	NN
cord-015021-pol2qm74	2871	4	production	production	NN
cord-015021-pol2qm74	2871	5	of	of	IN
cord-015021-pol2qm74	2871	6	17	17	CD
cord-015021-pol2qm74	2871	7	different	different	JJ
cord-015021-pol2qm74	2871	8	httman	httman	NN
cord-015021-pol2qm74	2871	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	2871	10	,	,	,
cord-015021-pol2qm74	2871	11	ILia	ILia	NNP
cord-015021-pol2qm74	2871	12	,	,	,
cord-015021-pol2qm74	2871	13	ILl	ILl	NNP
cord-015021-pol2qm74	2871	14	[	[	-LRB-
cord-015021-pol2qm74	2871	15	3	3	CD
cord-015021-pol2qm74	2871	16	,	,	,
cord-015021-pol2qm74	2871	17	ILlra	ILlra	NNP
cord-015021-pol2qm74	2871	18	,	,	,
cord-015021-pol2qm74	2871	19	IL2	IL2	NNP
cord-015021-pol2qm74	2871	20	,	,	,
cord-015021-pol2qm74	2871	21	IL3	IL3	NNP
cord-015021-pol2qm74	2871	22	,	,	,
cord-015021-pol2qm74	2871	23	IL4	IL4	NNP
cord-015021-pol2qm74	2871	24	,	,	,
cord-015021-pol2qm74	2871	25	IL5	IL5	NNP
cord-015021-pol2qm74	2871	26	,	,	,
cord-015021-pol2qm74	2871	27	IL6	IL6	NNP
cord-015021-pol2qm74	2871	28	,	,	,
cord-015021-pol2qm74	2871	29	ILS	ILS	NNP
cord-015021-pol2qm74	2871	30	,	,	,
cord-015021-pol2qm74	2871	31	ILl0	ILl0	NNP
cord-015021-pol2qm74	2871	32	,	,	,
cord-015021-pol2qm74	2871	33	GM	GM	NNP
cord-015021-pol2qm74	2871	34	-	-	HYPH
cord-015021-pol2qm74	2871	35	CSF	CSF	NNP
cord-015021-pol2qm74	2871	36	,	,	,
cord-015021-pol2qm74	2871	37	TNFa	TNFa	NNP
cord-015021-pol2qm74	2871	38	,	,	,
cord-015021-pol2qm74	2871	39	IFN	IFN	NNP
cord-015021-pol2qm74	2871	40	7	7	CD
cord-015021-pol2qm74	2871	41	and	and	CC
cord-015021-pol2qm74	2871	42	TGF[31.3	TGF[31.3	NNP
cord-015021-pol2qm74	2871	43	,	,	,
cord-015021-pol2qm74	2871	44	was	be	VBD
cord-015021-pol2qm74	2871	45	identified	identify	VBN
cord-015021-pol2qm74	2871	46	by	by	IN
cord-015021-pol2qm74	2871	47	indirect	indirect	JJ
cord-015021-pol2qm74	2871	48	immunohistochemical	immunohistochemical	JJ
cord-015021-pol2qm74	2871	49	staining	stain	VBG
cord-015021-pol2qm74	2871	50	procedures	procedure	NNS
cord-015021-pol2qm74	2871	51	and	and	CC
cord-015021-pol2qm74	2871	52	use	use	NN
cord-015021-pol2qm74	2871	53	of	of	IN
cord-015021-pol2qm74	2871	54	carefully	carefully	RB
cord-015021-pol2qm74	2871	55	selected	select	VBN
cord-015021-pol2qm74	2871	56	cytokine	cytokine	JJ
cord-015021-pol2qm74	2871	57	-	-	HYPH
cord-015021-pol2qm74	2871	58	specific	specific	JJ
cord-015021-pol2qm74	2871	59	mAb	mab	NN
cord-015021-pol2qm74	2871	60	's	's	POS
cord-015021-pol2qm74	2871	61	.	.	.
cord-015021-pol2qm74	2872	1	Frozen	frozen	JJ
cord-015021-pol2qm74	2872	2	sections	section	NNS
cord-015021-pol2qm74	2872	3	were	be	VBD
cord-015021-pol2qm74	2872	4	fixed	fix	VBN
cord-015021-pol2qm74	2872	5	with	with	IN
cord-015021-pol2qm74	2872	6	4	4	CD
cord-015021-pol2qm74	2872	7	%	%	NN
cord-015021-pol2qm74	2872	8	paraformaldehyde	paraformaldehyde	JJ
cord-015021-pol2qm74	2872	9	and	and	CC
cord-015021-pol2qm74	2872	10	permeabilized	permeabilize	VBN
cord-015021-pol2qm74	2872	11	by	by	IN
cord-015021-pol2qm74	2872	12	0.1	0.1	CD
cord-015021-pol2qm74	2872	13	%	%	NN
cord-015021-pol2qm74	2872	14	saponin	saponin	NN
cord-015021-pol2qm74	2872	15	treatment	treatment	NN
cord-015021-pol2qm74	2872	16	,	,	,
cord-015021-pol2qm74	2872	17	eluting	elute	VBG
cord-015021-pol2qm74	2872	18	cholesterol	cholesterol	NN
cord-015021-pol2qm74	2872	19	from	from	IN
cord-015021-pol2qm74	2872	20	the	the	DT
cord-015021-pol2qm74	2872	21	membranes	membrane	NNS
cord-015021-pol2qm74	2872	22	.	.	.
cord-015021-pol2qm74	2873	1	The	the	DT
cord-015021-pol2qm74	2873	2	intracellular	intracellular	JJ
cord-015021-pol2qm74	2873	3	presence	presence	NN
cord-015021-pol2qm74	2873	4	of	of	IN
cord-015021-pol2qm74	2873	5	all	all	DT
cord-015021-pol2qm74	2873	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	2873	7	except	except	IN
cord-015021-pol2qm74	2873	8	ILl	ILl	NNP
cord-015021-pol2qm74	2873	9	,	,	,
cord-015021-pol2qm74	2873	10	ILlra	ILlra	NNP
cord-015021-pol2qm74	2873	11	(	(	-LRB-
cord-015021-pol2qm74	2873	12	late	late	JJ
cord-015021-pol2qm74	2873	13	)	)	-RRB-
cord-015021-pol2qm74	2873	14	and	and	CC
cord-015021-pol2qm74	2873	15	TFG[31_3	TFG[31_3	NNP
cord-015021-pol2qm74	2873	16	,	,	,
cord-015021-pol2qm74	2873	17	could	could	MD
cord-015021-pol2qm74	2873	18	be	be	VB
cord-015021-pol2qm74	2873	19	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	2873	20	by	by	IN
cord-015021-pol2qm74	2873	21	a	a	DT
cord-015021-pol2qm74	2873	22	characteristic	characteristic	JJ
cord-015021-pol2qm74	2873	23	perinuclear	perinuclear	NN
cord-015021-pol2qm74	2873	24	configuration	configuration	NN
cord-015021-pol2qm74	2873	25	in	in	IN
cord-015021-pol2qm74	2873	26	producer	producer	NN
cord-015021-pol2qm74	2873	27	cells	cell	NNS
cord-015021-pol2qm74	2873	28	.	.	.
cord-015021-pol2qm74	2874	1	In	in	IN
cord-015021-pol2qm74	2874	2	addition	addition	NN
cord-015021-pol2qm74	2874	3	,	,	,
cord-015021-pol2qm74	2874	4	the	the	DT
cord-015021-pol2qm74	2874	5	immunoreactivity	immunoreactivity	NN
cord-015021-pol2qm74	2874	6	extended	extend	VBD
cord-015021-pol2qm74	2874	7	over	over	IN
cord-015021-pol2qm74	2874	8	a	a	DT
cord-015021-pol2qm74	2874	9	large	large	JJ
cord-015021-pol2qm74	2874	10	extracellular	extracellular	JJ
cord-015021-pol2qm74	2874	11	area	area	NN
cord-015021-pol2qm74	2874	12	encompassing	encompass	VBG
cord-015021-pol2qm74	2874	13	the	the	DT
cord-015021-pol2qm74	2874	14	producer	producer	NN
cord-015021-pol2qm74	2874	15	cell	cell	NN
cord-015021-pol2qm74	2874	16	.	.	.
cord-015021-pol2qm74	2875	1	A	a	DT
cord-015021-pol2qm74	2875	2	localization	localization	NN
cord-015021-pol2qm74	2875	3	of	of	IN
cord-015021-pol2qm74	2875	4	the	the	DT
cord-015021-pol2qm74	2875	5	cytokine	cytokine	NN
cord-015021-pol2qm74	2875	6	to	to	IN
cord-015021-pol2qm74	2875	7	the	the	DT
cord-015021-pol2qm74	2875	8	Golgi	Golgi	NNP
cord-015021-pol2qm74	2875	9	-	-	HYPH
cord-015021-pol2qm74	2875	10	organelle	organelle	NN
cord-015021-pol2qm74	2875	11	was	be	VBD
cord-015021-pol2qm74	2875	12	established	establish	VBN
cord-015021-pol2qm74	2875	13	by	by	IN
cord-015021-pol2qm74	2875	14	use	use	NN
cord-015021-pol2qm74	2875	15	of	of	IN
cord-015021-pol2qm74	2875	16	two	two	CD
cord-015021-pol2qm74	2875	17	culour	culour	NN
cord-015021-pol2qm74	2875	18	staining	stain	VBG
cord-015021-pol2qm74	2875	19	including	include	VBG
cord-015021-pol2qm74	2875	20	a	a	DT
cord-015021-pol2qm74	2875	21	haman	haman	NNP
cord-015021-pol2qm74	2875	22	Golgi	Golgi	NNP
cord-015021-pol2qm74	2875	23	complex	complex	JJ
cord-015021-pol2qm74	2875	24	specific	specific	JJ
cord-015021-pol2qm74	2875	25	mAb	mab	NN
cord-015021-pol2qm74	2875	26	.	.	.
cord-015021-pol2qm74	2876	1	This	this	DT
cord-015021-pol2qm74	2876	2	staining	staining	NN
cord-015021-pol2qm74	2876	3	pattern	pattern	NN
cord-015021-pol2qm74	2876	4	was	be	VBD
cord-015021-pol2qm74	2876	5	only	only	RB
cord-015021-pol2qm74	2876	6	evident	evident	JJ
cord-015021-pol2qm74	2876	7	in	in	IN
cord-015021-pol2qm74	2876	8	producer	producer	NN
cord-015021-pol2qm74	2876	9	cells	cell	NNS
cord-015021-pol2qm74	2876	10	because	because	IN
cord-015021-pol2qm74	2876	11	injection	injection	NN
cord-015021-pol2qm74	2876	12	of	of	IN
cord-015021-pol2qm74	2876	13	recombinant	recombinant	JJ
cord-015021-pol2qm74	2876	14	human	human	JJ
cord-015021-pol2qm74	2876	15	cytgkines	cytgkine	NNS
cord-015021-pol2qm74	2876	16	into	into	IN
cord-015021-pol2qm74	2876	17	the	the	DT
cord-015021-pol2qm74	2876	18	tissue	tissue	NN
cord-015021-pol2qm74	2876	19	caused	cause	VBD
cord-015021-pol2qm74	2876	20	a	a	DT
cord-015021-pol2qm74	2876	21	membraneous	membraneous	JJ
cord-015021-pol2qm74	2876	22	and	and	CC
cord-015021-pol2qm74	2876	23	extracellular	extracellular	JJ
cord-015021-pol2qm74	2876	24	staining	staining	NN
cord-015021-pol2qm74	2876	25	pattern	pattern	NN
cord-015021-pol2qm74	2876	26	.	.	.
cord-015021-pol2qm74	2877	1	Both	both	DT
cord-015021-pol2qm74	2877	2	the	the	DT
cord-015021-pol2qm74	2877	3	extra	extra	JJ
cord-015021-pol2qm74	2877	4	-	-	:
cord-015021-pol2qm74	2877	5	and	and	CC
cord-015021-pol2qm74	2877	6	the	the	DT
cord-015021-pol2qm74	2877	7	intracellular	intracellular	JJ
cord-015021-pol2qm74	2877	8	types	type	NNS
cord-015021-pol2qm74	2877	9	of	of	IN
cord-015021-pol2qm74	2877	10	staining	stain	VBG
cord-015021-pol2qm74	2877	11	reaction	reaction	NN
cord-015021-pol2qm74	2877	12	could	could	MD
cord-015021-pol2qm74	2877	13	,	,	,
cord-015021-pol2qm74	2877	14	however	however	RB
cord-015021-pol2qm74	2877	15	,	,	,
cord-015021-pol2qm74	2877	16	be	be	VB
cord-015021-pol2qm74	2877	17	blocked	block	VBN
cord-015021-pol2qm74	2877	18	by	by	IN
cord-015021-pol2qm74	2877	19	preincubating	preincubate	VBG
cord-015021-pol2qm74	2877	20	the	the	DT
cord-015021-pol2qm74	2877	21	cytokine	cytokine	JJ
cord-015021-pol2qm74	2877	22	specific	specific	JJ
cord-015021-pol2qm74	2877	23	mAb	mab	NN
cord-015021-pol2qm74	2877	24	with	with	IN
cord-015021-pol2qm74	2877	25	pure	pure	JJ
cord-015021-pol2qm74	2877	26	human	human	JJ
cord-015021-pol2qm74	2877	27	interleukins	interleukin	NNS
cord-015021-pol2qm74	2877	28	.	.	.
cord-015021-pol2qm74	2878	1	Oxygen	oxygen	NN
cord-015021-pol2qm74	2878	2	radicals	radical	NNS
cord-015021-pol2qm74	2878	3	(	(	-LRB-
cord-015021-pol2qm74	2878	4	OR	or	CC
cord-015021-pol2qm74	2878	5	)	)	-RRB-
cord-015021-pol2qm74	2878	6	directly	directly	RB
cord-015021-pol2qm74	2878	7	induce	induce	VB
cord-015021-pol2qm74	2878	8	lipid	lipid	NN
cord-015021-pol2qm74	2878	9	peroxidation	peroxidation	NN
cord-015021-pol2qm74	2878	10	,	,	,
cord-015021-pol2qm74	2878	11	indirectly	indirectly	RB
cord-015021-pol2qm74	2878	12	they	-PRON-	PRP
cord-015021-pol2qm74	2878	13	trigger	trigger	VBP
cord-015021-pol2qm74	2878	14	adhesion	adhesion	NN
cord-015021-pol2qm74	2878	15	and	and	CC
cord-015021-pol2qm74	2878	16	activation	activation	NN
cord-015021-pol2qm74	2878	17	of	of	IN
cord-015021-pol2qm74	2878	18	PMN	PMN	NNP
cord-015021-pol2qm74	2878	19	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2878	20	.	.	.
cord-015021-pol2qm74	2879	1	We	-PRON-	PRP
cord-015021-pol2qm74	2879	2	investigated	investigate	VBD
cord-015021-pol2qm74	2879	3	whether	whether	IN
cord-015021-pol2qm74	2879	4	OR	or	CC
cord-015021-pol2qm74	2879	5	also	also	RB
cord-015021-pol2qm74	2879	6	lead	lead	VB
cord-015021-pol2qm74	2879	7	to	to	IN
cord-015021-pol2qm74	2879	8	a	a	DT
cord-015021-pol2qm74	2879	9	release	release	NN
cord-015021-pol2qm74	2879	10	of	of	IN
cord-015021-pol2qm74	2879	11	acute	acute	JJ
cord-015021-pol2qm74	2879	12	-	-	HYPH
cord-015021-pol2qm74	2879	13	phase	phase	NN
cord-015021-pol2qm74	2879	14	response	response	NN
cord-015021-pol2qm74	2879	15	cytokins	cytokin	NNS
cord-015021-pol2qm74	2879	16	such	such	JJ
cord-015021-pol2qm74	2879	17	as	as	IN
cord-015021-pol2qm74	2879	18	TNF	tnf	NN
cord-015021-pol2qm74	2879	19	-	-	HYPH
cord-015021-pol2qm74	2879	20	alpha	alpha	NN
cord-015021-pol2qm74	2879	21	,	,	,
cord-015021-pol2qm74	2879	22	IL	IL	NNP
cord-015021-pol2qm74	2879	23	-	-	:
cord-015021-pol2qm74	2879	24	I	I	NNP
cord-015021-pol2qm74	2879	25	beta	beta	NN
cord-015021-pol2qm74	2879	26	or	or	CC
cord-015021-pol2qm74	2880	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	2880	2	in	in	IN
cord-015021-pol2qm74	2880	3	whole	whole	JJ
cord-015021-pol2qm74	2880	4	blood	blood	NN
cord-015021-pol2qm74	2880	5	cultures	culture	NNS
cord-015021-pol2qm74	2880	6	to	to	TO
cord-015021-pol2qm74	2880	7	maintain	maintain	VB
cord-015021-pol2qm74	2880	8	the	the	DT
cord-015021-pol2qm74	2880	9	induced	induce	VBN
cord-015021-pol2qm74	2880	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2880	11	reaction	reaction	NN
cord-015021-pol2qm74	2880	12	.	.	.
cord-015021-pol2qm74	2881	1	Methods	method	NNS
cord-015021-pol2qm74	2881	2	:	:	:
cord-015021-pol2qm74	2881	3	Blood	blood	NN
cord-015021-pol2qm74	2881	4	samples	sample	NNS
cord-015021-pol2qm74	2881	5	from	from	IN
cord-015021-pol2qm74	2881	6	healthy	healthy	JJ
cord-015021-pol2qm74	2881	7	volunteers	volunteer	NNS
cord-015021-pol2qm74	2881	8	(	(	-LRB-
cord-015021-pol2qm74	2881	9	n=10	n=10	NNP
cord-015021-pol2qm74	2881	10	)	)	-RRB-
cord-015021-pol2qm74	2881	11	were	be	VBD
cord-015021-pol2qm74	2881	12	incubated	incubate	VBN
cord-015021-pol2qm74	2881	13	at	at	IN
cord-015021-pol2qm74	2881	14	37	37	CD
cord-015021-pol2qm74	2881	15	°	°	NN
cord-015021-pol2qm74	2881	16	C	c	NN
cord-015021-pol2qm74	2881	17	.	.	.
cord-015021-pol2qm74	2882	1	OR	or	CC
cord-015021-pol2qm74	2882	2	were	be	VBD
cord-015021-pol2qm74	2882	3	produced	produce	VBN
cord-015021-pol2qm74	2882	4	by	by	IN
cord-015021-pol2qm74	2882	5	the	the	DT
cord-015021-pol2qm74	2882	6	xanthine	xanthine	NN
cord-015021-pol2qm74	2882	7	oxidase	oxidase	NN
cord-015021-pol2qm74	2882	8	(	(	-LRB-
cord-015021-pol2qm74	2882	9	XO)/	XO)/	NNP
cord-015021-pol2qm74	2882	10	hypoxanthine	hypoxanthine	NNP
cord-015021-pol2qm74	2882	11	(	(	-LRB-
cord-015021-pol2qm74	2882	12	HX	HX	NNP
cord-015021-pol2qm74	2882	13	)	)	-RRB-
cord-015021-pol2qm74	2882	14	system	system	NN
cord-015021-pol2qm74	2882	15	.	.	.
cord-015021-pol2qm74	2883	1	After	after	IN
cord-015021-pol2qm74	2883	2	0,30,60,120,240	0,30,60,120,240	CD
cord-015021-pol2qm74	2883	3	and	and	CC
cord-015021-pol2qm74	2883	4	360	360	CD
cord-015021-pol2qm74	2883	5	minutes	minute	NNS
cord-015021-pol2qm74	2883	6	plasma	plasma	NN
cord-015021-pol2qm74	2883	7	levels	level	NNS
cord-015021-pol2qm74	2883	8	of	of	IN
cord-015021-pol2qm74	2883	9	TNF	tnf	NN
cord-015021-pol2qm74	2883	10	-	-	HYPH
cord-015021-pol2qm74	2883	11	alpha	alpha	NN
cord-015021-pol2qm74	2883	12	,	,	,
cord-015021-pol2qm74	2883	13	IL	IL	NNP
cord-015021-pol2qm74	2883	14	-	-	:
cord-015021-pol2qm74	2883	15	I	I	NNP
cord-015021-pol2qm74	2883	16	beta	beta	NN
cord-015021-pol2qm74	2883	17	and	and	CC
cord-015021-pol2qm74	2884	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	2884	2	were	be	VBD
cord-015021-pol2qm74	2884	3	determined	determine	VBN
cord-015021-pol2qm74	2884	4	with	with	IN
cord-015021-pol2qm74	2884	5	ELISA	ELISA	NNP
cord-015021-pol2qm74	2884	6	kits	kit	NNS
cord-015021-pol2qm74	2884	7	.	.	.
cord-015021-pol2qm74	2885	1	Results	result	NNS
cord-015021-pol2qm74	2885	2	:	:	:
cord-015021-pol2qm74	2886	1	Under	under	IN
cord-015021-pol2qm74	2886	2	the	the	DT
cord-015021-pol2qm74	2886	3	influence	influence	NN
cord-015021-pol2qm74	2886	4	of	of	IN
cord-015021-pol2qm74	2886	5	OR	OR	NNP
cord-015021-pol2qm74	2886	6	TNF	TNF	NNP
cord-015021-pol2qm74	2886	7	-	-	HYPH
cord-015021-pol2qm74	2886	8	alpha	alpha	NN
cord-015021-pol2qm74	2886	9	plasma	plasma	NN
cord-015021-pol2qm74	2886	10	levels	level	NNS
cord-015021-pol2qm74	2886	11	increased	increase	VBD
cord-015021-pol2qm74	2886	12	from	from	IN
cord-015021-pol2qm74	2886	13	0,5	0,5	CD
cord-015021-pol2qm74	2886	14	pg	pg	NNP
cord-015021-pol2qm74	2886	15	/	/	SYM
cord-015021-pol2qm74	2886	16	ml	ml	XX
cord-015021-pol2qm74	2886	17	at	at	IN
cord-015021-pol2qm74	2886	18	0min	0min	CD
cord-015021-pol2qm74	2886	19	to	to	IN
cord-015021-pol2qm74	2887	1	14pg	14pg	NNP
cord-015021-pol2qm74	2887	2	/	/	SYM
cord-015021-pol2qm74	2887	3	ml	ml	NN
cord-015021-pol2qm74	2887	4	,	,	,
cord-015021-pol2qm74	2887	5	236pg	236pg	NNP
cord-015021-pol2qm74	2887	6	/	/	SYM
cord-015021-pol2qm74	2887	7	ml	ml	NN
cord-015021-pol2qm74	2887	8	,	,	,
cord-015021-pol2qm74	2887	9	343pg	343pg	NNP
cord-015021-pol2qm74	2887	10	/	/	SYM
cord-015021-pol2qm74	2887	11	ml	ml	NN
cord-015021-pol2qm74	2887	12	after	after	IN
cord-015021-pol2qm74	2887	13	60	60	CD
cord-015021-pol2qm74	2887	14	,	,	,
cord-015021-pol2qm74	2887	15	120	120	CD
cord-015021-pol2qm74	2887	16	and	and	CC
cord-015021-pol2qm74	2887	17	240	240	CD
cord-015021-pol2qm74	2887	18	min	min	NN
cord-015021-pol2qm74	2887	19	.	.	.
cord-015021-pol2qm74	2888	1	IL	IL	NNP
cord-015021-pol2qm74	2888	2	-	-	HYPH
cord-015021-pol2qm74	2888	3	ibeta	ibeta	NNP
cord-015021-pol2qm74	2888	4	(	(	-LRB-
cord-015021-pol2qm74	2888	5	0,3pg	0,3pg	CD
cord-015021-pol2qm74	2888	6	/	/	SYM
cord-015021-pol2qm74	2888	7	ml	ml	NN
cord-015021-pol2qm74	2888	8	,	,	,
cord-015021-pol2qm74	2888	9	0,6pg	0,6pg	CD
cord-015021-pol2qm74	2889	1	/ml	/ml	NFP
cord-015021-pol2qm74	2889	2	,	,	,
cord-015021-pol2qm74	2889	3	1,5pg	1,5pg	CD
cord-015021-pol2qm74	2889	4	/	/	SYM
cord-015021-pol2qm74	2889	5	ml	ml	NN
cord-015021-pol2qm74	2889	6	,	,	,
cord-015021-pol2qm74	2889	7	81pg	81pg	NNP
cord-015021-pol2qm74	2889	8	/	/	SYM
cord-015021-pol2qm74	2889	9	ml	ml	NN
cord-015021-pol2qm74	2889	10	and	and	CC
cord-015021-pol2qm74	2889	11	169pg	169pg	NNP
cord-015021-pol2qm74	2889	12	/	/	SYM
cord-015021-pol2qm74	2889	13	ml	ml	XX
cord-015021-pol2qm74	2889	14	after	after	IN
cord-015021-pol2qm74	2889	15	0,60,120,240	0,60,120,240	CD
cord-015021-pol2qm74	2889	16	and	and	CC
cord-015021-pol2qm74	2889	17	360min	360min	CD
cord-015021-pol2qm74	2889	18	)	)	-RRB-
cord-015021-pol2qm74	2889	19	and	and	CC
cord-015021-pol2qm74	2890	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	2890	2	(	(	-LRB-
cord-015021-pol2qm74	2890	3	0,2pg	0,2pg	CD
cord-015021-pol2qm74	2890	4	/	/	SYM
cord-015021-pol2qm74	2890	5	ml	ml	NN
cord-015021-pol2qm74	2890	6	,	,	,
cord-015021-pol2qm74	2890	7	l	l	NNP
cord-015021-pol2qm74	2890	8	,	,	,
cord-015021-pol2qm74	2890	9	lpg	lpg	NNP
cord-015021-pol2qm74	2890	10	/	/	SYM
cord-015021-pol2qm74	2890	11	ml	ml	XX
cord-015021-pol2qm74	2890	12	,	,	,
cord-015021-pol2qm74	2891	1	4,1pg	4,1pg	CD
cord-015021-pol2qm74	2891	2	/	/	SYM
cord-015021-pol2qm74	2891	3	ml	ml	NN
cord-015021-pol2qm74	2891	4	,	,	,
cord-015021-pol2qm74	2891	5	58pg	58pg	NN
cord-015021-pol2qm74	2891	6	/	/	SYM
cord-015021-pol2qm74	2891	7	ml	ml	NN
cord-015021-pol2qm74	2891	8	and	and	CC
cord-015021-pol2qm74	2891	9	72,9pg	72,9pg	NNP
cord-015021-pol2qm74	2891	10	/	/	SYM
cord-015021-pol2qm74	2891	11	ml	ml	XX
cord-015021-pol2qm74	2891	12	after	after	IN
cord-015021-pol2qm74	2891	13	0,60,120,240	0,60,120,240	CD
cord-015021-pol2qm74	2892	1	and	and	CC
cord-015021-pol2qm74	2892	2	360min	360min	CD
cord-015021-pol2qm74	2892	3	)	)	-RRB-
cord-015021-pol2qm74	2893	1	plasma	plasma	NN
cord-015021-pol2qm74	2893	2	levels	level	NNS
cord-015021-pol2qm74	2893	3	were	be	VBD
cord-015021-pol2qm74	2893	4	increased	increase	VBN
cord-015021-pol2qm74	2893	5	60min	60min	NN
cord-015021-pol2qm74	2893	6	later	later	RB
cord-015021-pol2qm74	2893	7	than	than	IN
cord-015021-pol2qm74	2893	8	TNF	tnf	NN
cord-015021-pol2qm74	2893	9	-	-	HYPH
cord-015021-pol2qm74	2893	10	alpha	alpha	NN
cord-015021-pol2qm74	2893	11	.	.	.
cord-015021-pol2qm74	2894	1	Summary	summary	NN
cord-015021-pol2qm74	2894	2	:	:	:
cord-015021-pol2qm74	2895	1	These	these	DT
cord-015021-pol2qm74	2895	2	data	datum	NNS
cord-015021-pol2qm74	2895	3	suggest	suggest	VBP
cord-015021-pol2qm74	2895	4	that	that	IN
cord-015021-pol2qm74	2895	5	OR	or	CC
cord-015021-pol2qm74	2895	6	do	do	VBP
cord-015021-pol2qm74	2895	7	not	not	RB
cord-015021-pol2qm74	2895	8	only	only	RB
cord-015021-pol2qm74	2895	9	play	play	VB
cord-015021-pol2qm74	2895	10	an	an	DT
cord-015021-pol2qm74	2895	11	important	important	JJ
cord-015021-pol2qm74	2895	12	role	role	NN
cord-015021-pol2qm74	2895	13	in	in	IN
cord-015021-pol2qm74	2895	14	initial	initial	JJ
cord-015021-pol2qm74	2895	15	accumulation	accumulation	NN
cord-015021-pol2qm74	2895	16	and	and	CC
cord-015021-pol2qm74	2895	17	activation	activation	NN
cord-015021-pol2qm74	2895	18	of	of	IN
cord-015021-pol2qm74	2895	19	PMN	PMN	NNP
cord-015021-pol2qm74	2895	20	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	2895	21	but	but	CC
cord-015021-pol2qm74	2895	22	also	also	RB
cord-015021-pol2qm74	2895	23	lead	lead	VBP
cord-015021-pol2qm74	2895	24	to	to	IN
cord-015021-pol2qm74	2895	25	a	a	DT
cord-015021-pol2qm74	2895	26	stimulation	stimulation	NN
cord-015021-pol2qm74	2895	27	of	of	IN
cord-015021-pol2qm74	2895	28	monocytes	monocyte	NNS
cord-015021-pol2qm74	2895	29	to	to	TO
cord-015021-pol2qm74	2895	30	produce	produce	VB
cord-015021-pol2qm74	2895	31	the	the	DT
cord-015021-pol2qm74	2895	32	acute	acute	JJ
cord-015021-pol2qm74	2895	33	phase	phase	NN
cord-015021-pol2qm74	2895	34	reaction	reaction	NN
cord-015021-pol2qm74	2895	35	cytokins	cytokins	NNP
cord-015021-pol2qm74	2895	36	TNF	TNF	NNP
cord-015021-pol2qm74	2895	37	-	-	HYPH
cord-015021-pol2qm74	2895	38	alpha	alpha	NN
cord-015021-pol2qm74	2895	39	,	,	,
cord-015021-pol2qm74	2895	40	IL	IL	NNP
cord-015021-pol2qm74	2895	41	-	-	:
cord-015021-pol2qm74	2895	42	I	I	NNP
cord-015021-pol2qm74	2895	43	beta	beta	NN
cord-015021-pol2qm74	2895	44	and	and	CC
cord-015021-pol2qm74	2895	45	IL-6	IL-6	NNP
cord-015021-pol2qm74	2895	46	to	to	TO
cord-015021-pol2qm74	2895	47	maintain	maintain	VB
cord-015021-pol2qm74	2895	48	and	and	CC
cord-015021-pol2qm74	2895	49	strengthen	strengthen	VB
cord-015021-pol2qm74	2895	50	the	the	DT
cord-015021-pol2qm74	2895	51	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2895	52	reaction	reaction	NN
cord-015021-pol2qm74	2895	53	.	.	.
cord-015021-pol2qm74	2896	1	Department	Department	NNP
cord-015021-pol2qm74	2896	2	of	of	IN
cord-015021-pol2qm74	2896	3	General	General	NNP
cord-015021-pol2qm74	2896	4	Surgery	Surgery	NNP
cord-015021-pol2qm74	2896	5	,	,	,
cord-015021-pol2qm74	2896	6	SteinhSvelstr.9	SteinhSvelstr.9	NNP
cord-015021-pol2qm74	2896	7	,	,	,
cord-015021-pol2qm74	2896	8	89070	89070	CD
cord-015021-pol2qm74	2896	9	Ulm	Ulm	NNP
cord-015021-pol2qm74	2896	10	,	,	,
cord-015021-pol2qm74	2896	11	Germany	Germany	NNP
cord-015021-pol2qm74	2896	12	Jan	Jan	NNP
cord-015021-pol2qm74	2896	13	K.	K.	NNP
cord-015021-pol2qm74	2896	14	Horn	Horn	NNP
cord-015021-pol2qm74	2896	15	MD	MD	NNP
cord-015021-pol2qm74	2896	16	,	,	,
cord-015021-pol2qm74	2896	17	Greg	Greg	NNP
cord-015021-pol2qm74	2896	18	A.	a.	NN
cord-015021-pol2qm74	2896	19	Hamon	Hamon	NNP
cord-015021-pol2qm74	2896	20	MD	MD	NNP
cord-015021-pol2qm74	2896	21	,	,	,
cord-015021-pol2qm74	2896	22	Robert	Robert	NNP
cord-015021-pol2qm74	2896	23	H.	H.	NNP
cord-015021-pol2qm74	2896	24	Mulloy	Mulloy	NNP
cord-015021-pol2qm74	2896	25	MD	MD	NNP
cord-015021-pol2qm74	2896	26	,	,	,
cord-015021-pol2qm74	2896	27	Greg	Greg	NNP
cord-015021-pol2qm74	2896	28	Chen	Chen	NNP
cord-015021-pol2qm74	2896	29	BS	BS	NNP
cord-015021-pol2qm74	2896	30	,	,	,
cord-015021-pol2qm74	2896	31	Rebecca	Rebecca	NNP
cord-015021-pol2qm74	2896	32	Chow	Chow	NNP
cord-015021-pol2qm74	2896	33	BS	BS	NNP
cord-015021-pol2qm74	2896	34	,	,	,
cord-015021-pol2qm74	2896	35	and	and	CC
cord-015021-pol2qm74	2896	36	Christof	Christof	NNP
cord-015021-pol2qm74	2896	37	Birkenmaier	Birkenmaier	NNP
cord-015021-pol2qm74	2896	38	MD	MD	NNP
cord-015021-pol2qm74	2896	39	.	.	.
cord-015021-pol2qm74	2897	1	Transforming	transform	VBG
cord-015021-pol2qm74	2897	2	growth	growth	NN
cord-015021-pol2qm74	2897	3	factor	factor	NN
cord-015021-pol2qm74	2897	4	-	-	:
cord-015021-pol2qm74	2897	5	I	i	NN
cord-015021-pol2qm74	2898	1	~l	~l	NNP
cord-015021-pol2qm74	2898	2	(	(	-LRB-
cord-015021-pol2qm74	2898	3	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2898	4	)	)	-RRB-
cord-015021-pol2qm74	2898	5	is	be	VBZ
cord-015021-pol2qm74	2898	6	released	release	VBN
cord-015021-pol2qm74	2898	7	from	from	IN
cord-015021-pol2qm74	2898	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2898	9	ceils	ceil	NNS
cord-015021-pol2qm74	2898	10	following	follow	VBG
cord-015021-pol2qm74	2898	11	injury	injury	NN
cord-015021-pol2qm74	2898	12	and	and	CC
cord-015021-pol2qm74	2898	13	in	in	IN
cord-015021-pol2qm74	2898	14	sepsis	sepsis	NN
cord-015021-pol2qm74	2898	15	.	.	.
cord-015021-pol2qm74	2899	1	In	in	IN
cord-015021-pol2qm74	2899	2	vitro	vitro	FW
cord-015021-pol2qm74	2899	3	experiments	experiment	NNS
cord-015021-pol2qm74	2899	4	have	have	VBP
cord-015021-pol2qm74	2899	5	confirmed	confirm	VBN
cord-015021-pol2qm74	2899	6	that	that	IN
cord-015021-pol2qm74	2899	7	low	low	JJ
cord-015021-pol2qm74	2899	8	concentrations	concentration	NNS
cord-015021-pol2qm74	2899	9	of	of	IN
cord-015021-pol2qm74	2899	10	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2899	11	(	(	-LRB-
cord-015021-pol2qm74	2899	12	0.1	0.1	CD
cord-015021-pol2qm74	2899	13	-	-	SYM
cord-015021-pol2qm74	2899	14	1.0	1.0	CD
cord-015021-pol2qm74	2899	15	ng	ng	NN
cord-015021-pol2qm74	2899	16	/	/	SYM
cord-015021-pol2qm74	2899	17	ml	ml	NN
cord-015021-pol2qm74	2899	18	)	)	-RRB-
cord-015021-pol2qm74	2899	19	are	be	VBP
cord-015021-pol2qm74	2899	20	chemoattractive	chemoattractive	JJ
cord-015021-pol2qm74	2899	21	for	for	IN
cord-015021-pol2qm74	2899	22	monocytes	monocyte	NNS
cord-015021-pol2qm74	2899	23	,	,	,
cord-015021-pol2qm74	2899	24	whereas	whereas	IN
cord-015021-pol2qm74	2899	25	higher	high	JJR
cord-015021-pol2qm74	2899	26	levels	level	NNS
cord-015021-pol2qm74	2899	27	of	of	IN
cord-015021-pol2qm74	2899	28	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2899	29	(	(	-LRB-
cord-015021-pol2qm74	2899	30	>	>	NFP
cord-015021-pol2qm74	2899	31	5.0	5.0	CD
cord-015021-pol2qm74	2899	32	ng	ng	NN
cord-015021-pol2qm74	2899	33	/	/	SYM
cord-015021-pol2qm74	2899	34	ml	ml	NN
cord-015021-pol2qm74	2899	35	)	)	-RRB-
cord-015021-pol2qm74	2899	36	potentiate	potentiate	VBP
cord-015021-pol2qm74	2899	37	production	production	NN
cord-015021-pol2qm74	2899	38	of	of	IN
cord-015021-pol2qm74	2899	39	the	the	DT
cord-015021-pol2qm74	2899	40	immunedepressive	immunedepressive	JJ
cord-015021-pol2qm74	2899	41	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	2899	42	E	e	NN
cord-015021-pol2qm74	2899	43	2	2	CD
cord-015021-pol2qm74	2899	44	.	.	.
cord-015021-pol2qm74	2900	1	Other	other	JJ
cord-015021-pol2qm74	2900	2	investigators	investigator	NNS
cord-015021-pol2qm74	2900	3	have	have	VBP
cord-015021-pol2qm74	2900	4	shown	show	VBN
cord-015021-pol2qm74	2900	5	that	that	IN
cord-015021-pol2qm74	2900	6	TGF-]31	tgf-]31	DT
cord-015021-pol2qm74	2900	7	can	can	MD
cord-015021-pol2qm74	2900	8	cause	cause	VB
cord-015021-pol2qm74	2900	9	the	the	DT
cord-015021-pol2qm74	2900	10	appearance	appearance	NN
cord-015021-pol2qm74	2900	11	of	of	IN
cord-015021-pol2qm74	2900	12	CD16	CD16	NNP
cord-015021-pol2qm74	2900	13	(	(	-LRB-
cord-015021-pol2qm74	2900	14	Fc	Fc	NNP
cord-015021-pol2qm74	2900	15	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	2900	16	receptor	receptor	NN
cord-015021-pol2qm74	2900	17	)	)	-RRB-
cord-015021-pol2qm74	2900	18	on	on	IN
cord-015021-pol2qm74	2900	19	monocytes	monocyte	NNS
cord-015021-pol2qm74	2900	20	exposed	expose	VBN
cord-015021-pol2qm74	2900	21	to	to	IN
cord-015021-pol2qm74	2900	22	10	10	CD
cord-015021-pol2qm74	2900	23	ng	ng	NN
cord-015021-pol2qm74	2900	24	/	/	SYM
cord-015021-pol2qm74	2900	25	ml	ml	NNS
cord-015021-pol2qm74	2900	26	of	of	IN
cord-015021-pol2qm74	2900	27	TGF-[~I	tgf-[~i	NN
cord-015021-pol2qm74	2900	28	for	for	IN
cord-015021-pol2qm74	2900	29	24	24	CD
cord-015021-pol2qm74	2900	30	hours	hour	NNS
cord-015021-pol2qm74	2900	31	.	.	.
cord-015021-pol2qm74	2901	1	Monocytes	monocyte	NNS
cord-015021-pol2qm74	2901	2	also	also	RB
cord-015021-pol2qm74	2901	3	express	express	VBP
cord-015021-pol2qm74	2901	4	on	on	IN
cord-015021-pol2qm74	2901	5	their	-PRON-	PRP$
cord-015021-pol2qm74	2901	6	surface	surface	NN
cord-015021-pol2qm74	2901	7	a	a	DT
cord-015021-pol2qm74	2901	8	glycoprotein	glycoprotein	NN
cord-015021-pol2qm74	2901	9	that	that	WDT
cord-015021-pol2qm74	2901	10	binds	bind	VBZ
cord-015021-pol2qm74	2901	11	complexes	complex	NNS
cord-015021-pol2qm74	2901	12	of	of	IN
cord-015021-pol2qm74	2901	13	lipopolysaceharide	lipopolysaceharide	NN
cord-015021-pol2qm74	2901	14	(	(	-LRB-
cord-015021-pol2qm74	2901	15	LPS	LPS	NNP
cord-015021-pol2qm74	2901	16	)	)	-RRB-
cord-015021-pol2qm74	2901	17	and	and	CC
cord-015021-pol2qm74	2901	18	LPSbinding	lpsbinde	VBG
cord-015021-pol2qm74	2901	19	protein	protein	NN
cord-015021-pol2qm74	2901	20	(	(	-LRB-
cord-015021-pol2qm74	2901	21	LBP	LBP	NNP
cord-015021-pol2qm74	2901	22	)	)	-RRB-
cord-015021-pol2qm74	2901	23	.	.	.
cord-015021-pol2qm74	2902	1	Such	such	JJ
cord-015021-pol2qm74	2902	2	binding	binding	NN
cord-015021-pol2qm74	2902	3	is	be	VBZ
cord-015021-pol2qm74	2902	4	associated	associate	VBN
cord-015021-pol2qm74	2902	5	with	with	IN
cord-015021-pol2qm74	2902	6	generation	generation	NN
cord-015021-pol2qm74	2902	7	of	of	IN
cord-015021-pol2qm74	2902	8	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	2902	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	2902	10	such	such	JJ
cord-015021-pol2qm74	2902	11	as	as	IN
cord-015021-pol2qm74	2902	12	tumor	tumor	NN
cord-015021-pol2qm74	2902	13	necrosis	necrosis	NN
cord-015021-pol2qm74	2902	14	factor	factor	NN
cord-015021-pol2qm74	2902	15	alpha	alpha	NN
cord-015021-pol2qm74	2902	16	.	.	.
cord-015021-pol2qm74	2903	1	We	-PRON-	PRP
cord-015021-pol2qm74	2903	2	have	have	VBP
cord-015021-pol2qm74	2903	3	shown	show	VBN
cord-015021-pol2qm74	2903	4	that	that	IN
cord-015021-pol2qm74	2903	5	CD14	CD14	NNP
cord-015021-pol2qm74	2903	6	is	be	VBZ
cord-015021-pol2qm74	2903	7	depressed	depress	VBN
cord-015021-pol2qm74	2903	8	in	in	IN
cord-015021-pol2qm74	2903	9	septic	septic	JJ
cord-015021-pol2qm74	2903	10	patients	patient	NNS
cord-015021-pol2qm74	2903	11	and	and	CC
cord-015021-pol2qm74	2903	12	therefore	therefore	RB
cord-015021-pol2qm74	2903	13	we	-PRON-	PRP
cord-015021-pol2qm74	2903	14	hypothesized	hypothesize	VBD
cord-015021-pol2qm74	2903	15	that	that	IN
cord-015021-pol2qm74	2903	16	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2903	17	could	could	MD
cord-015021-pol2qm74	2903	18	account	account	VB
cord-015021-pol2qm74	2903	19	for	for	IN
cord-015021-pol2qm74	2903	20	the	the	DT
cord-015021-pol2qm74	2903	21	down	down	JJ
cord-015021-pol2qm74	2903	22	-	-	HYPH
cord-015021-pol2qm74	2903	23	regulation	regulation	NN
cord-015021-pol2qm74	2903	24	of	of	IN
cord-015021-pol2qm74	2903	25	CD14	CD14	NNP
cord-015021-pol2qm74	2903	26	observed	observe	VBD
cord-015021-pol2qm74	2903	27	in	in	IN
cord-015021-pol2qm74	2903	28	these	these	DT
cord-015021-pol2qm74	2903	29	individuals	individual	NNS
cord-015021-pol2qm74	2903	30	.	.	.
cord-015021-pol2qm74	2904	1	We	-PRON-	PRP
cord-015021-pol2qm74	2904	2	incubated	incubate	VBD
cord-015021-pol2qm74	2904	3	normal	normal	JJ
cord-015021-pol2qm74	2904	4	human	human	JJ
cord-015021-pol2qm74	2904	5	monocytes	monocyte	NNS
cord-015021-pol2qm74	2904	6	with	with	IN
cord-015021-pol2qm74	2904	7	platelet	platelet	NN
cord-015021-pol2qm74	2904	8	-	-	HYPH
cord-015021-pol2qm74	2904	9	derived	derive	VBN
cord-015021-pol2qm74	2904	10	TGF-[31	tgf-[31	RB
cord-015021-pol2qm74	2904	11	for	for	IN
cord-015021-pol2qm74	2904	12	2	2	CD
cord-015021-pol2qm74	2904	13	and	and	CC
cord-015021-pol2qm74	2904	14	24	24	CD
cord-015021-pol2qm74	2904	15	hours	hour	NNS
cord-015021-pol2qm74	2904	16	at	at	IN
cord-015021-pol2qm74	2904	17	37	37	CD
cord-015021-pol2qm74	2904	18	°	°	NN
cord-015021-pol2qm74	2904	19	C	c	NN
cord-015021-pol2qm74	2904	20	and	and	CC
cord-015021-pol2qm74	2904	21	examined	examine	VBD
cord-015021-pol2qm74	2904	22	ceils	ceil	NNS
cord-015021-pol2qm74	2904	23	for	for	IN
cord-015021-pol2qm74	2904	24	CD14	CD14	NNP
cord-015021-pol2qm74	2904	25	and	and	CC
cord-015021-pol2qm74	2904	26	CD16	CD16	NNP
cord-015021-pol2qm74	2904	27	expression	expression	NN
cord-015021-pol2qm74	2904	28	using	use	VBG
cord-015021-pol2qm74	2904	29	flow	flow	NN
cord-015021-pol2qm74	2904	30	cytometry	cytometry	NN
cord-015021-pol2qm74	2904	31	after	after	IN
cord-015021-pol2qm74	2904	32	immunnfluoreseent	immunnfluoreseent	NN
cord-015021-pol2qm74	2904	33	staining	stain	VBG
cord-015021-pol2qm74	2904	34	with	with	IN
cord-015021-pol2qm74	2904	35	appropriate	appropriate	JJ
cord-015021-pol2qm74	2904	36	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	2904	37	antibodies	antibody	NNS
cord-015021-pol2qm74	2904	38	.	.	.
cord-015021-pol2qm74	2905	1	Monocytes	monocyte	NNS
cord-015021-pol2qm74	2905	2	were	be	VBD
cord-015021-pol2qm74	2905	3	selected	select	VBN
cord-015021-pol2qm74	2905	4	on	on	IN
cord-015021-pol2qm74	2905	5	the	the	DT
cord-015021-pol2qm74	2905	6	by	by	IN
cord-015021-pol2qm74	2905	7	usual	usual	JJ
cord-015021-pol2qm74	2905	8	criteria	criterion	NNS
cord-015021-pol2qm74	2905	9	for	for	IN
cord-015021-pol2qm74	2905	10	size	size	NN
cord-015021-pol2qm74	2905	11	and	and	CC
cord-015021-pol2qm74	2905	12	granularity	granularity	NN
cord-015021-pol2qm74	2905	13	.	.	.
cord-015021-pol2qm74	2906	1	Non	non	JJ
cord-015021-pol2qm74	2906	2	-	-	JJ
cord-015021-pol2qm74	2906	3	viable	viable	JJ
cord-015021-pol2qm74	2906	4	ceils	ceil	NNS
cord-015021-pol2qm74	2906	5	were	be	VBD
cord-015021-pol2qm74	2906	6	excluded	exclude	VBN
cord-015021-pol2qm74	2906	7	with	with	IN
cord-015021-pol2qm74	2906	8	the	the	DT
cord-015021-pol2qm74	2906	9	use	use	NN
cord-015021-pol2qm74	2906	10	of	of	IN
cord-015021-pol2qm74	2906	11	propidium	propidium	NN
cord-015021-pol2qm74	2906	12	iodide	iodide	NN
cord-015021-pol2qm74	2906	13	.	.	.
cord-015021-pol2qm74	2907	1	Two	two	CD
cord-015021-pol2qm74	2907	2	populations	population	NNS
cord-015021-pol2qm74	2907	3	of	of	IN
cord-015021-pol2qm74	2907	4	monocytes	monocyte	NNS
cord-015021-pol2qm74	2907	5	could	could	MD
cord-015021-pol2qm74	2907	6	be	be	VB
cord-015021-pol2qm74	2907	7	found	find	VBN
cord-015021-pol2qm74	2907	8	afcer	afcer	NNP
cord-015021-pol2qm74	2907	9	incubation	incubation	NN
cord-015021-pol2qm74	2907	10	at	at	IN
cord-015021-pol2qm74	2907	11	37	37	CD
cord-015021-pol2qm74	2907	12	°	°	NN
cord-015021-pol2qm74	2907	13	C	c	NN
cord-015021-pol2qm74	2907	14	alone	alone	RB
cord-015021-pol2qm74	2907	15	.	.	.
cord-015021-pol2qm74	2908	1	One	one	CD
cord-015021-pol2qm74	2908	2	displaying	display	VBG
cord-015021-pol2qm74	2908	3	high	high	JJ
cord-015021-pol2qm74	2908	4	density	density	NN
cord-015021-pol2qm74	2908	5	of	of	IN
cord-015021-pol2qm74	2908	6	CD14	CD14	NNP
cord-015021-pol2qm74	2908	7	had	have	VBD
cord-015021-pol2qm74	2908	8	increased	increase	VBN
cord-015021-pol2qm74	2908	9	fluorescence	fluorescence	NN
cord-015021-pol2qm74	2908	10	over	over	IN
cord-015021-pol2qm74	2908	11	the	the	DT
cord-015021-pol2qm74	2908	12	homogeneous	homogeneous	JJ
cord-015021-pol2qm74	2908	13	expression	expression	NN
cord-015021-pol2qm74	2908	14	of	of	IN
cord-015021-pol2qm74	2908	15	CD14	CD14	NNP
cord-015021-pol2qm74	2908	16	in	in	IN
cord-015021-pol2qm74	2908	17	cells	cell	NNS
cord-015021-pol2qm74	2908	18	maintained	maintain	VBD
cord-015021-pol2qm74	2908	19	at	at	IN
cord-015021-pol2qm74	2908	20	4	4	CD
cord-015021-pol2qm74	2908	21	°	°	NN
cord-015021-pol2qm74	2908	22	C	c	NN
cord-015021-pol2qm74	2908	23	(	(	-LRB-
cord-015021-pol2qm74	2908	24	baseline	baseline	NN
cord-015021-pol2qm74	2908	25	)	)	-RRB-
cord-015021-pol2qm74	2908	26	.	.	.
cord-015021-pol2qm74	2909	1	The	the	DT
cord-015021-pol2qm74	2909	2	other	other	JJ
cord-015021-pol2qm74	2909	3	population	population	NN
cord-015021-pol2qm74	2909	4	displayed	display	VBD
cord-015021-pol2qm74	2909	5	decreased	decrease	VBN
cord-015021-pol2qm74	2909	6	CD14	CD14	NNP
cord-015021-pol2qm74	2909	7	expression	expression	NN
cord-015021-pol2qm74	2909	8	relative	relative	JJ
cord-015021-pol2qm74	2909	9	to	to	IN
cord-015021-pol2qm74	2909	10	the	the	DT
cord-015021-pol2qm74	2909	11	baseline	baseline	JJ
cord-015021-pol2qm74	2909	12	cells	cell	NNS
cord-015021-pol2qm74	2909	13	.	.	.
cord-015021-pol2qm74	2910	1	TGF	TGF	NNP
cord-015021-pol2qm74	2910	2	-	-	HYPH
cord-015021-pol2qm74	2910	3	I	I	NNP
cord-015021-pol2qm74	2911	1	~I	~I	NFP
cord-015021-pol2qm74	2911	2	(	(	-LRB-
cord-015021-pol2qm74	2911	3	10	10	CD
cord-015021-pol2qm74	2911	4	-	-	SYM
cord-015021-pol2qm74	2911	5	50	50	CD
cord-015021-pol2qm74	2911	6	ng	ng	NN
cord-015021-pol2qm74	2911	7	/	/	SYM
cord-015021-pol2qm74	2911	8	ml	ml	NN
cord-015021-pol2qm74	2911	9	)	)	-RRB-
cord-015021-pol2qm74	2911	10	caused	cause	VBD
cord-015021-pol2qm74	2911	11	a	a	DT
cord-015021-pol2qm74	2911	12	shift	shift	NN
cord-015021-pol2qm74	2911	13	of	of	IN
cord-015021-pol2qm74	2911	14	ceils	ceil	NNS
cord-015021-pol2qm74	2911	15	from	from	IN
cord-015021-pol2qm74	2911	16	the	the	DT
cord-015021-pol2qm74	2911	17	high	high	JJ
cord-015021-pol2qm74	2911	18	density	density	NN
cord-015021-pol2qm74	2911	19	into	into	IN
cord-015021-pol2qm74	2911	20	the	the	DT
cord-015021-pol2qm74	2911	21	low	low	JJ
cord-015021-pol2qm74	2911	22	density	density	NN
cord-015021-pol2qm74	2911	23	CD14	CD14	NNP
cord-015021-pol2qm74	2911	24	population	population	NN
cord-015021-pol2qm74	2911	25	.	.	.
cord-015021-pol2qm74	2912	1	This	this	DT
cord-015021-pol2qm74	2912	2	trend	trend	NN
cord-015021-pol2qm74	2912	3	was	be	VBD
cord-015021-pol2qm74	2912	4	observed	observe	VBN
cord-015021-pol2qm74	2912	5	within	within	IN
cord-015021-pol2qm74	2912	6	2	2	CD
cord-015021-pol2qm74	2912	7	hours	hour	NNS
cord-015021-pol2qm74	2912	8	of	of	IN
cord-015021-pol2qm74	2912	9	incubation	incubation	NN
cord-015021-pol2qm74	2912	10	and	and	CC
cord-015021-pol2qm74	2912	11	was	be	VBD
cord-015021-pol2qm74	2912	12	complete	complete	JJ
cord-015021-pol2qm74	2912	13	by	by	IN
cord-015021-pol2qm74	2912	14	24	24	CD
cord-015021-pol2qm74	2912	15	hours	hour	NNS
cord-015021-pol2qm74	2912	16	.	.	.
cord-015021-pol2qm74	2913	1	We	-PRON-	PRP
cord-015021-pol2qm74	2913	2	observed	observe	VBD
cord-015021-pol2qm74	2913	3	a	a	DT
cord-015021-pol2qm74	2913	4	net	net	JJ
cord-015021-pol2qm74	2913	5	decrease	decrease	NN
cord-015021-pol2qm74	2913	6	in	in	IN
cord-015021-pol2qm74	2913	7	CD14	CD14	NNP
cord-015021-pol2qm74	2913	8	expression	expression	NN
cord-015021-pol2qm74	2913	9	0f32	0f32	CD
cord-015021-pol2qm74	2913	10	%	%	NN
cord-015021-pol2qm74	2913	11	for	for	IN
cord-015021-pol2qm74	2913	12	all	all	DT
cord-015021-pol2qm74	2913	13	subjects	subject	NNS
cord-015021-pol2qm74	2913	14	studied	study	VBD
cord-015021-pol2qm74	2913	15	(	(	-LRB-
cord-015021-pol2qm74	2913	16	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	2913	17	vs	vs	IN
cord-015021-pol2qm74	2913	18	controls	control	NNS
cord-015021-pol2qm74	2913	19	)	)	-RRB-
cord-015021-pol2qm74	2913	20	.	.	.
cord-015021-pol2qm74	2914	1	Phorbol	Phorbol	NNP
cord-015021-pol2qm74	2914	2	myristate	myristate	NN
cord-015021-pol2qm74	2914	3	acetate	acetate	NN
cord-015021-pol2qm74	2914	4	(	(	-LRB-
cord-015021-pol2qm74	2914	5	100	100	CD
cord-015021-pol2qm74	2914	6	ng	ng	NN
cord-015021-pol2qm74	2914	7	/	/	SYM
cord-015021-pol2qm74	2914	8	ml	ml	NN
cord-015021-pol2qm74	2914	9	)	)	-RRB-
cord-015021-pol2qm74	2914	10	also	also	RB
cord-015021-pol2qm74	2914	11	caused	cause	VBD
cord-015021-pol2qm74	2914	12	down	down	NN
cord-015021-pol2qm74	2914	13	-	-	HYPH
cord-015021-pol2qm74	2914	14	regulation	regulation	NN
cord-015021-pol2qm74	2914	15	of	of	IN
cord-015021-pol2qm74	2914	16	CD14	CD14	NNP
cord-015021-pol2qm74	2914	17	to	to	IN
cord-015021-pol2qm74	2914	18	a	a	DT
cord-015021-pol2qm74	2914	19	similar	similar	JJ
cord-015021-pol2qm74	2914	20	degree	degree	NN
cord-015021-pol2qm74	2914	21	as	as	IN
cord-015021-pol2qm74	2914	22	TFG	TFG	NNP
cord-015021-pol2qm74	2914	23	-	-	HYPH
cord-015021-pol2qm74	2914	24	I~	I~	NNP
cord-015021-pol2qm74	2915	1	I.	i.	LS
cord-015021-pol2qm74	2915	2	We	-PRON-	PRP
cord-015021-pol2qm74	2915	3	also	also	RB
cord-015021-pol2qm74	2915	4	confirmed	confirm	VBD
cord-015021-pol2qm74	2915	5	that	that	IN
cord-015021-pol2qm74	2915	6	monocytes	monocyte	NNS
cord-015021-pol2qm74	2915	7	could	could	MD
cord-015021-pol2qm74	2915	8	be	be	VB
cord-015021-pol2qm74	2915	9	induced	induce	VBN
cord-015021-pol2qm74	2915	10	to	to	TO
cord-015021-pol2qm74	2915	11	express	express	VB
cord-015021-pol2qm74	2915	12	CD16	CD16	NNP
cord-015021-pol2qm74	2915	13	after	after	IN
cord-015021-pol2qm74	2915	14	incubation	incubation	NN
cord-015021-pol2qm74	2915	15	with	with	IN
cord-015021-pol2qm74	2915	16	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2915	17	(	(	-LRB-
cord-015021-pol2qm74	2915	18	10	10	CD
cord-015021-pol2qm74	2915	19	ng	ng	NN
cord-015021-pol2qm74	2915	20	/	/	SYM
cord-015021-pol2qm74	2915	21	ml	ml	NN
cord-015021-pol2qm74	2915	22	)	)	-RRB-
cord-015021-pol2qm74	2915	23	for	for	IN
cord-015021-pol2qm74	2915	24	24	24	CD
cord-015021-pol2qm74	2915	25	hours	hour	NNS
cord-015021-pol2qm74	2915	26	.	.	.
cord-015021-pol2qm74	2916	1	These	these	DT
cord-015021-pol2qm74	2916	2	studies	study	NNS
cord-015021-pol2qm74	2916	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2916	4	that	that	IN
cord-015021-pol2qm74	2916	5	monocytes	monocyte	NNS
cord-015021-pol2qm74	2916	6	incubated	incubate	VBN
cord-015021-pol2qm74	2916	7	with	with	IN
cord-015021-pol2qm74	2916	8	immunodepressive	immunodepressive	JJ
cord-015021-pol2qm74	2916	9	levels	level	NNS
cord-015021-pol2qm74	2916	10	of	of	IN
cord-015021-pol2qm74	2916	11	regulation	regulation	NN
cord-015021-pol2qm74	2916	12	of	of	IN
cord-015021-pol2qm74	2916	13	CD14	CD14	NNP
cord-015021-pol2qm74	2916	14	by	by	IN
cord-015021-pol2qm74	2916	15	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2916	16	deplete	deplete	VBP
cord-015021-pol2qm74	2916	17	their	-PRON-	PRP$
cord-015021-pol2qm74	2916	18	surface	surface	NN
cord-015021-pol2qm74	2916	19	expression	expression	NN
cord-015021-pol2qm74	2916	20	of	of	IN
cord-015021-pol2qm74	2916	21	CD14	CD14	NNP
cord-015021-pol2qm74	2916	22	while	while	IN
cord-015021-pol2qm74	2916	23	generating	generate	VBG
cord-015021-pol2qm74	2916	24	CD16	CD16	NNP
cord-015021-pol2qm74	2916	25	.	.	.
cord-015021-pol2qm74	2917	1	This	this	DT
cord-015021-pol2qm74	2917	2	down	down	JJ
cord-015021-pol2qm74	2917	3	-	-	HYPH
cord-015021-pol2qm74	2917	4	regulation	regulation	NN
cord-015021-pol2qm74	2917	5	of	of	IN
cord-015021-pol2qm74	2917	6	CD14	CD14	NNP
cord-015021-pol2qm74	2917	7	by	by	IN
cord-015021-pol2qm74	2917	8	TGF-131	TGF-131	NNP
cord-015021-pol2qm74	2917	9	correlates	correlate	VBZ
cord-015021-pol2qm74	2917	10	with	with	IN
cord-015021-pol2qm74	2917	11	our	-PRON-	PRP$
cord-015021-pol2qm74	2917	12	clinical	clinical	JJ
cord-015021-pol2qm74	2917	13	observations	observation	NNS
cord-015021-pol2qm74	2917	14	of	of	IN
cord-015021-pol2qm74	2917	15	lower	low	JJR
cord-015021-pol2qm74	2917	16	CD14	CD14	NNP
cord-015021-pol2qm74	2917	17	expression	expression	NN
cord-015021-pol2qm74	2917	18	on	on	IN
cord-015021-pol2qm74	2917	19	monocytes	monocyte	NNS
cord-015021-pol2qm74	2917	20	obtained	obtain	VBN
cord-015021-pol2qm74	2917	21	from	from	IN
cord-015021-pol2qm74	2917	22	septic	septic	JJ
cord-015021-pol2qm74	2917	23	patients	patient	NNS
cord-015021-pol2qm74	2917	24	.	.	.
cord-015021-pol2qm74	2918	1	For	for	IN
cord-015021-pol2qm74	2918	2	over	over	IN
cord-015021-pol2qm74	2918	3	25	25	CD
cord-015021-pol2qm74	2918	4	years	year	NNS
cord-015021-pol2qm74	2918	5	,	,	,
cord-015021-pol2qm74	2918	6	activated	activate	VBD
cord-015021-pol2qm74	2918	7	T	t	NN
cord-015021-pol2qm74	2918	8	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2918	9	have	have	VBP
cord-015021-pol2qm74	2918	10	been	be	VBN
cord-015021-pol2qm74	2918	11	considered	consider	VBN
cord-015021-pol2qm74	2918	12	to	to	TO
cord-015021-pol2qm74	2918	13	be	be	VB
cord-015021-pol2qm74	2918	14	the	the	DT
cord-015021-pol2qm74	2918	15	cellular	cellular	JJ
cord-015021-pol2qm74	2918	16	source	source	NN
cord-015021-pol2qm74	2918	17	of	of	IN
cord-015021-pol2qm74	2918	18	MIF	MIF	NNP
cord-015021-pol2qm74	2918	19	.	.	.
cord-015021-pol2qm74	2919	1	We	-PRON-	PRP
cord-015021-pol2qm74	2919	2	recently	recently	RB
cord-015021-pol2qm74	2919	3	isolated	isolate	VBD
cord-015021-pol2qm74	2919	4	and	and	CC
cord-015021-pol2qm74	2919	5	cloned	clone	VBN
cord-015021-pol2qm74	2919	6	the	the	DT
cord-015021-pol2qm74	2919	7	murine	murine	JJ
cord-015021-pol2qm74	2919	8	homolog	homolog	NN
cord-015021-pol2qm74	2919	9	of	of	IN
cord-015021-pol2qm74	2919	10	MIF	MIF	NNP
cord-015021-pol2qm74	2919	11	after	after	IN
cord-015021-pol2qm74	2919	12	identifying	identify	VBG
cord-015021-pol2qm74	2919	13	the	the	DT
cord-015021-pol2qm74	2919	14	specific	specific	JJ
cord-015021-pol2qm74	2919	15	secretion	secretion	NN
cord-015021-pol2qm74	2919	16	of	of	IN
cord-015021-pol2qm74	2919	17	this	this	DT
cord-015021-pol2qm74	2919	18	protein	protein	NN
cord-015021-pol2qm74	2919	19	by	by	IN
cord-015021-pol2qm74	2919	20	LPSstimulated	lpsstimulated	JJ
cord-015021-pol2qm74	2919	21	pituitary	pituitary	NN
cord-015021-pol2qm74	2919	22	cells	cell	NNS
cord-015021-pol2qm74	2919	23	in	in	IN
cord-015021-pol2qm74	2919	24	vitro	vitro	FW
cord-015021-pol2qm74	2919	25	and	and	CC
cord-015021-pol2qm74	2919	26	in	in	IN
cord-015021-pol2qm74	2919	27	vivo	vivo	NNP
cord-015021-pol2qm74	2919	28	.	.	.
cord-015021-pol2qm74	2920	1	However	however	RB
cord-015021-pol2qm74	2920	2	,	,	,
cord-015021-pol2qm74	2920	3	further	further	JJ
cord-015021-pol2qm74	2920	4	experiments	experiment	NNS
cord-015021-pol2qm74	2920	5	showed	show	VBD
cord-015021-pol2qm74	2920	6	that	that	IN
cord-015021-pol2qm74	2920	7	MIF	MIF	NNP
cord-015021-pol2qm74	2920	8	protein	protein	NN
cord-015021-pol2qm74	2920	9	is	be	VBZ
cord-015021-pol2qm74	2920	10	detectable	detectable	JJ
cord-015021-pol2qm74	2920	11	both	both	DT
cord-015021-pol2qm74	2920	12	in	in	IN
cord-015021-pol2qm74	2920	13	T	t	NN
cord-015021-pol2qm74	2920	14	-	-	HYPH
cord-015021-pol2qm74	2920	15	cell	cell	NN
cord-015021-pol2qm74	2920	16	deficient	deficient	JJ
cord-015021-pol2qm74	2920	17	(	(	-LRB-
cord-015021-pol2qm74	2920	18	nude	nude	JJ
cord-015021-pol2qm74	2920	19	)	)	-RRB-
cord-015021-pol2qm74	2920	20	and	and	CC
cord-015021-pol2qm74	2920	21	hypophyseetomized	hypophyseetomize	VBN
cord-015021-pol2qm74	2920	22	mice	mouse	NNS
cord-015021-pol2qm74	2920	23	,	,	,
cord-015021-pol2qm74	2920	24	suggesting	suggest	VBG
cord-015021-pol2qm74	2920	25	that	that	IN
cord-015021-pol2qm74	2920	26	yet	yet	RB
cord-015021-pol2qm74	2920	27	additional	additional	JJ
cord-015021-pol2qm74	2920	28	cell	cell	NN
cord-015021-pol2qm74	2920	29	types	type	NNS
cord-015021-pol2qm74	2920	30	may	may	MD
cord-015021-pol2qm74	2920	31	produce	produce	VB
cord-015021-pol2qm74	2920	32	MIF	MIF	NNP
cord-015021-pol2qm74	2920	33	in	in	IN
cord-015021-pol2qm74	2920	34	vivo	vivo	NN
cord-015021-pol2qm74	2920	35	.	.	.
cord-015021-pol2qm74	2921	1	Since	since	IN
cord-015021-pol2qm74	2921	2	monocytes	monocyte	NNS
cord-015021-pol2qm74	2921	3	/	/	SYM
cord-015021-pol2qm74	2921	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	2921	5	are	be	VBP
cord-015021-pol2qm74	2921	6	a	a	DT
cord-015021-pol2qm74	2921	7	major	major	JJ
cord-015021-pol2qm74	2921	8	source	source	NN
cord-015021-pol2qm74	2921	9	of	of	IN
cord-015021-pol2qm74	2921	10	the	the	DT
cord-015021-pol2qm74	2921	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	2921	12	that	that	WDT
cord-015021-pol2qm74	2921	13	appear	appear	VBP
cord-015021-pol2qm74	2921	14	in	in	IN
cord-015021-pol2qm74	2921	15	response	response	NN
cord-015021-pol2qm74	2921	16	to	to	IN
cord-015021-pol2qm74	2921	17	LPS	LPS	NNP
cord-015021-pol2qm74	2921	18	administration	administration	NN
cord-015021-pol2qm74	2921	19	,	,	,
cord-015021-pol2qm74	2921	20	we	-PRON-	PRP
cord-015021-pol2qm74	2921	21	examined	examine	VBD
cord-015021-pol2qm74	2921	22	the	the	DT
cord-015021-pol2qm74	2921	23	possibility	possibility	NN
cord-015021-pol2qm74	2921	24	that	that	IN
cord-015021-pol2qm74	2921	25	MIF	MIF	NNP
cord-015021-pol2qm74	2921	26	also	also	RB
cord-015021-pol2qm74	2921	27	is	be	VBZ
cord-015021-pol2qm74	2921	28	expressed	express	VBN
cord-015021-pol2qm74	2921	29	in	in	IN
cord-015021-pol2qm74	2921	30	cells	cell	NNS
cord-015021-pol2qm74	2921	31	of	of	IN
cord-015021-pol2qm74	2921	32	the	the	DT
cord-015021-pol2qm74	2921	33	monocyte	monocyte	NNP
cord-015021-pol2qm74	2921	34	/	/	SYM
cord-015021-pol2qm74	2921	35	macrophage	macrophage	NN
cord-015021-pol2qm74	2921	36	lineage	lineage	NN
cord-015021-pol2qm74	2921	37	.	.	.
cord-015021-pol2qm74	2922	1	We	-PRON-	PRP
cord-015021-pol2qm74	2922	2	found	find	VBD
cord-015021-pol2qm74	2922	3	that	that	IN
cord-015021-pol2qm74	2922	4	MIF	MIF	NNP
cord-015021-pol2qm74	2922	5	is	be	VBZ
cord-015021-pol2qm74	2922	6	expressed	express	VBN
cord-015021-pol2qm74	2922	7	constitutively	constitutively	RB
cord-015021-pol2qm74	2922	8	in	in	IN
cord-015021-pol2qm74	2922	9	the	the	DT
cord-015021-pol2qm74	2922	10	murine	murine	JJ
cord-015021-pol2qm74	2922	11	macrophage	macrophage	NN
cord-015021-pol2qm74	2922	12	-	-	HYPH
cord-015021-pol2qm74	2922	13	line	line	NN
cord-015021-pol2qm74	2922	14	RAW264.7	RAW264.7	NNP
cord-015021-pol2qm74	2922	15	and	and	CC
cord-015021-pol2qm74	2922	16	in	in	IN
cord-015021-pol2qm74	2922	17	thioglycollate	thioglycollate	RB
cord-015021-pol2qm74	2922	18	-	-	HYPH
cord-015021-pol2qm74	2922	19	elicited	elicit	VBN
cord-015021-pol2qm74	2922	20	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	2922	21	macrophages	macrophage	NNS
cord-015021-pol2qm74	2922	22	.	.	.
cord-015021-pol2qm74	2923	1	Significant	significant	JJ
cord-015021-pol2qm74	2923	2	amounts	amount	NNS
cord-015021-pol2qm74	2923	3	of	of	IN
cord-015021-pol2qm74	2923	4	MIF	MIF	NNP
cord-015021-pol2qm74	2923	5	mRNA	mRNA	NNP
cord-015021-pol2qm74	2923	6	(	(	-LRB-
cord-015021-pol2qm74	2923	7	RT	RT	NNP
cord-015021-pol2qm74	2923	8	-	-	HYPH
cord-015021-pol2qm74	2923	9	PCR	PCR	NNP
cord-015021-pol2qm74	2923	10	)	)	-RRB-
cord-015021-pol2qm74	2923	11	and	and	CC
cord-015021-pol2qm74	2923	12	protein	protein	NN
cord-015021-pol2qm74	2923	13	(	(	-LRB-
cord-015021-pol2qm74	2923	14	Western	western	JJ
cord-015021-pol2qm74	2923	15	blotting	blotting	NN
cord-015021-pol2qm74	2923	16	)	)	-RRB-
cord-015021-pol2qm74	2923	17	were	be	VBD
cord-015021-pol2qm74	2923	18	observed	observe	VBN
cord-015021-pol2qm74	2923	19	in	in	IN
cord-015021-pol2qm74	2923	20	cell	cell	NN
cord-015021-pol2qm74	2923	21	lysates	lysate	NNS
cord-015021-pol2qm74	2923	22	.	.	.
cord-015021-pol2qm74	2924	1	In	in	IN
cord-015021-pol2qm74	2924	2	RAW	raw	JJ
cord-015021-pol2qm74	2924	3	264.7	264.7	CD
cord-015021-pol2qm74	2924	4	cells	cell	NNS
cord-015021-pol2qm74	2924	5	,	,	,
cord-015021-pol2qm74	2924	6	MIF	MIF	NNP
cord-015021-pol2qm74	2924	7	secretion	secretion	NN
cord-015021-pol2qm74	2924	8	was	be	VBD
cord-015021-pol2qm74	2924	9	induced	induce	VBN
cord-015021-pol2qm74	2924	10	by	by	IN
cord-015021-pol2qm74	2924	11	as	as	RB
cord-015021-pol2qm74	2924	12	little	little	JJ
cord-015021-pol2qm74	2924	13	as	as	IN
cord-015021-pol2qm74	2924	14	10	10	CD
cord-015021-pol2qm74	2924	15	pg	pg	NN
cord-015021-pol2qm74	2924	16	/	/	SYM
cord-015021-pol2qm74	2924	17	ml	ml	NNS
cord-015021-pol2qm74	2924	18	of	of	IN
cord-015021-pol2qm74	2924	19	LPS	LPS	NNP
cord-015021-pol2qm74	2924	20	(	(	-LRB-
cord-015021-pol2qm74	2924	21	E.coli	E.coli	NNS
cord-015021-pol2qm74	2924	22	011	011	CD
cord-015021-pol2qm74	2924	23	l	l	NN
cord-015021-pol2qm74	2924	24	:	:	:
cord-015021-pol2qm74	2924	25	B4	B4	NNP
cord-015021-pol2qm74	2924	26	)	)	-RRB-
cord-015021-pol2qm74	2924	27	,	,	,
cord-015021-pol2qm74	2924	28	peaked	peak	VBD
cord-015021-pol2qm74	2924	29	at	at	IN
cord-015021-pol2qm74	2924	30	1	1	CD
cord-015021-pol2qm74	2924	31	ng	ng	NN
cord-015021-pol2qm74	2924	32	/	/	SYM
cord-015021-pol2qm74	2924	33	ml	ml	XX
cord-015021-pol2qm74	2924	34	,	,	,
cord-015021-pol2qm74	2924	35	but	but	CC
cord-015021-pol2qm74	2924	36	was	be	VBD
cord-015021-pol2qm74	2924	37	not	not	RB
cord-015021-pol2qm74	2924	38	detectable	detectable	JJ
cord-015021-pol2qm74	2924	39	at	at	IN
cord-015021-pol2qm74	2924	40	LPS	LPS	NNP
cord-015021-pol2qm74	2924	41	concentrations	concentration	NNS
cord-015021-pol2qm74	2925	1	>	>	XX
cord-015021-pol2qm74	2926	1	1	1	CD
cord-015021-pol2qm74	2926	2	txg	txg	NNP
cord-015021-pol2qm74	2926	3	/	/	SYM
cord-015021-pol2qm74	2926	4	ml	ml	NN
cord-015021-pol2qm74	2926	5	.	.	.
cord-015021-pol2qm74	2927	1	Similar	similar	JJ
cord-015021-pol2qm74	2927	2	data	datum	NNS
cord-015021-pol2qm74	2927	3	were	be	VBD
cord-015021-pol2qm74	2927	4	obtained	obtain	VBN
cord-015021-pol2qm74	2927	5	with	with	IN
cord-015021-pol2qm74	2927	6	elicited	elicit	VBN
cord-015021-pol2qm74	2927	7	macrophages	macrophage	NNS
cord-015021-pol2qm74	2927	8	,	,	,
cord-015021-pol2qm74	2927	9	but	but	CC
cord-015021-pol2qm74	2927	10	higher	high	JJR
cord-015021-pol2qm74	2927	11	LPS	LPS	NNP
cord-015021-pol2qm74	2927	12	concentrations	concentration	NNS
cord-015021-pol2qm74	2927	13	were	be	VBD
cord-015021-pol2qm74	2927	14	required	require	VBN
cord-015021-pol2qm74	2927	15	,	,	,
cord-015021-pol2qm74	2927	16	unless	unless	IN
cord-015021-pol2qm74	2927	17	the	the	DT
cord-015021-pol2qm74	2927	18	cells	cell	NNS
cord-015021-pol2qm74	2927	19	had	have	VBD
cord-015021-pol2qm74	2927	20	been	be	VBN
cord-015021-pol2qm74	2927	21	preincubated	preincubate	VBN
cord-015021-pol2qm74	2927	22	with	with	IN
cord-015021-pol2qm74	2927	23	IFN	IFN	NNP
cord-015021-pol2qm74	2927	24	7	7	CD
cord-015021-pol2qm74	2927	25	.	.	.
cord-015021-pol2qm74	2928	1	Production	production	NN
cord-015021-pol2qm74	2928	2	of	of	IN
cord-015021-pol2qm74	2928	3	MIF	MIF	NNP
cord-015021-pol2qm74	2928	4	by	by	IN
cord-015021-pol2qm74	2928	5	LPS	LPS	NNP
cord-015021-pol2qm74	2928	6	-	-	HYPH
cord-015021-pol2qm74	2928	7	stimulated	stimulate	VBN
cord-015021-pol2qm74	2928	8	(	(	-LRB-
cord-015021-pol2qm74	2928	9	l	l	NNP
cord-015021-pol2qm74	2928	10	ng	ng	NNP
cord-015021-pol2qm74	2928	11	/	/	SYM
cord-015021-pol2qm74	2928	12	ml	ml	NN
cord-015021-pol2qm74	2928	13	)	)	-RRB-
cord-015021-pol2qm74	2928	14	macrophages	macrophage	NNS
cord-015021-pol2qm74	2928	15	peaked	peak	VBD
cord-015021-pol2qm74	2928	16	at	at	IN
cord-015021-pol2qm74	2928	17	12	12	CD
cord-015021-pol2qm74	2928	18	hr	hr	NN
cord-015021-pol2qm74	2928	19	.	.	.
cord-015021-pol2qm74	2929	1	Expression	expression	NN
cord-015021-pol2qm74	2929	2	ofMIF	ofmif	JJ
cord-015021-pol2qm74	2930	1	mRNA	mRNA	NNP
cord-015021-pol2qm74	2930	2	and	and	CC
cord-015021-pol2qm74	2931	1	TNF	TNF	NNP
cord-015021-pol2qm74	2931	2	mRNA	mRNA	NNP
cord-015021-pol2qm74	2932	1	by	by	IN
cord-015021-pol2qm74	2932	2	LPS	LPS	NNP
cord-015021-pol2qm74	2932	3	-	-	HYPH
cord-015021-pol2qm74	2932	4	stimulated	stimulate	VBN
cord-015021-pol2qm74	2932	5	RAW	raw	JJ
cord-015021-pol2qm74	2932	6	264.7	264.7	CD
cord-015021-pol2qm74	2932	7	macrophages	macrophage	NNS
cord-015021-pol2qm74	2932	8	was	be	VBD
cord-015021-pol2qm74	2932	9	investigated	investigate	VBN
cord-015021-pol2qm74	2932	10	by	by	IN
cord-015021-pol2qm74	2932	11	RT	RT	NNP
cord-015021-pol2qm74	2932	12	-	-	HYPH
cord-015021-pol2qm74	2932	13	PCR	PCR	NNP
cord-015021-pol2qm74	2932	14	.	.	.
cord-015021-pol2qm74	2933	1	As	as	IN
cord-015021-pol2qm74	2933	2	expected	expect	VBN
cord-015021-pol2qm74	2933	3	TNF	TNF	NNP
cord-015021-pol2qm74	2933	4	mRNA	mrna	NN
cord-015021-pol2qm74	2933	5	expression	expression	NN
cord-015021-pol2qm74	2933	6	increased	increase	VBD
cord-015021-pol2qm74	2933	7	over	over	IN
cord-015021-pol2qm74	2933	8	the	the	DT
cord-015021-pol2qm74	2933	9	range	range	NN
cord-015021-pol2qm74	2933	10	of	of	IN
cord-015021-pol2qm74	2933	11	LPS	LPS	NNP
cord-015021-pol2qm74	2933	12	concentrations	concentration	NNS
cord-015021-pol2qm74	2933	13	(	(	-LRB-
cord-015021-pol2qm74	2933	14	1	1	CD
cord-015021-pol2qm74	2933	15	pg	pg	NN
cord-015021-pol2qm74	2933	16	/	/	SYM
cord-015021-pol2qm74	2933	17	ml	ml	NN
cord-015021-pol2qm74	2933	18	to	to	IN
cord-015021-pol2qm74	2933	19	1	1	CD
cord-015021-pol2qm74	2933	20	p_g	p_g	NNP
cord-015021-pol2qm74	2933	21	/	/	SYM
cord-015021-pol2qm74	2933	22	ml	ml	NN
cord-015021-pol2qm74	2933	23	)	)	-RRB-
cord-015021-pol2qm74	2933	24	.	.	.
cord-015021-pol2qm74	2934	1	In	in	IN
cord-015021-pol2qm74	2934	2	contrast	contrast	NN
cord-015021-pol2qm74	2934	3	,	,	,
cord-015021-pol2qm74	2934	4	levels	level	NNS
cord-015021-pol2qm74	2934	5	of	of	IN
cord-015021-pol2qm74	2934	6	MIF	MIF	NNP
cord-015021-pol2qm74	2934	7	mRNA	mRNA	NNP
cord-015021-pol2qm74	2934	8	correlated	correlate	VBD
cord-015021-pol2qm74	2934	9	inversely	inversely	RB
cord-015021-pol2qm74	2934	10	with	with	IN
cord-015021-pol2qm74	2934	11	LPS	LPS	NNP
cord-015021-pol2qm74	2934	12	concentration	concentration	NN
cord-015021-pol2qm74	2934	13	.	.	.
cord-015021-pol2qm74	2935	1	By	by	IN
cord-015021-pol2qm74	2935	2	competitive	competitive	JJ
cord-015021-pol2qm74	2935	3	PCR	PCR	NNP
cord-015021-pol2qm74	2935	4	,	,	,
cord-015021-pol2qm74	2935	5	MIF	MIF	NNP
cord-015021-pol2qm74	2935	6	mRNA	mRNA	NNP
cord-015021-pol2qm74	2935	7	was	be	VBD
cord-015021-pol2qm74	2935	8	observed	observe	VBN
cord-015021-pol2qm74	2935	9	to	to	TO
cord-015021-pol2qm74	2935	10	increase	increase	VB
cord-015021-pol2qm74	2935	11	approximately	approximately	RB
cord-015021-pol2qm74	2935	12	2-fold	2-fold	CD
cord-015021-pol2qm74	2935	13	after	after	IN
cord-015021-pol2qm74	2935	14	LPS	LPS	NNP
cord-015021-pol2qm74	2935	15	induction	induction	NN
cord-015021-pol2qm74	2935	16	(	(	-LRB-
cord-015021-pol2qm74	2935	17	100	100	CD
cord-015021-pol2qm74	2935	18	pg	pg	NN
cord-015021-pol2qm74	2935	19	/	/	SYM
cord-015021-pol2qm74	2935	20	ml	ml	NNP
cord-015021-pol2qm74	2935	21	)	)	-RRB-
cord-015021-pol2qm74	2935	22	.	.	.
cord-015021-pol2qm74	2936	1	MIF	MIF	NNP
cord-015021-pol2qm74	2936	2	secretion	secretion	NN
cord-015021-pol2qm74	2936	3	also	also	RB
cord-015021-pol2qm74	2936	4	was	be	VBD
cord-015021-pol2qm74	2936	5	induced	induce	VBN
cord-015021-pol2qm74	2936	6	by	by	IN
cord-015021-pol2qm74	2936	7	TNFoc	TNFoc	NNP
cord-015021-pol2qm74	2936	8	(	(	-LRB-
cord-015021-pol2qm74	2936	9	1	1	CD
cord-015021-pol2qm74	2936	10	ng	ng	NN
cord-015021-pol2qm74	2936	11	/	/	SYM
cord-015021-pol2qm74	2936	12	ml	ml	NN
cord-015021-pol2qm74	2936	13	)	)	-RRB-
cord-015021-pol2qm74	2936	14	and	and	CC
cord-015021-pol2qm74	2936	15	IFN	IFN	NNP
cord-015021-pol2qm74	2936	16	?	?	.
cord-015021-pol2qm74	2937	1	(	(	-LRB-
cord-015021-pol2qm74	2937	2	10	10	CD
cord-015021-pol2qm74	2937	3	IU	IU	NNP
cord-015021-pol2qm74	2937	4	/	/	SYM
cord-015021-pol2qm74	2937	5	ml	ml	NN
cord-015021-pol2qm74	2937	6	)	)	-RRB-
cord-015021-pol2qm74	2937	7	,	,	,
cord-015021-pol2qm74	2937	8	but	but	CC
cord-015021-pol2qm74	2937	9	not	not	RB
cord-015021-pol2qm74	2937	10	by	by	IN
cord-015021-pol2qm74	2938	1	IL-113	IL-113	NNP
cord-015021-pol2qm74	2938	2	and	and	CC
cord-015021-pol2qm74	2938	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	2938	4	(	(	-LRB-
cord-015021-pol2qm74	2938	5	up	up	IN
cord-015021-pol2qm74	2938	6	to	to	TO
cord-015021-pol2qm74	2938	7	10	10	CD
cord-015021-pol2qm74	2938	8	ng	ng	NN
cord-015021-pol2qm74	2938	9	/	/	SYM
cord-015021-pol2qm74	2938	10	ml	ml	NN
cord-015021-pol2qm74	2938	11	)	)	-RRB-
cord-015021-pol2qm74	2938	12	.	.	.
cord-015021-pol2qm74	2939	1	LPS	LPS	NNP
cord-015021-pol2qm74	2939	2	and	and	CC
cord-015021-pol2qm74	2939	3	IFN	IFN	NNP
cord-015021-pol2qm74	2939	4	7	7	CD
cord-015021-pol2qm74	2939	5	had	have	VBD
cord-015021-pol2qm74	2939	6	additive	additive	NN
cord-015021-pol2qm74	2939	7	effects	effect	NNS
cord-015021-pol2qm74	2939	8	in	in	IN
cord-015021-pol2qm74	2939	9	inducing	induce	VBG
cord-015021-pol2qm74	2939	10	MIF	MIF	NNP
cord-015021-pol2qm74	2939	11	secretion	secretion	NN
cord-015021-pol2qm74	2939	12	.	.	.
cord-015021-pol2qm74	2940	1	In	in	IN
cord-015021-pol2qm74	2940	2	separate	separate	JJ
cord-015021-pol2qm74	2940	3	experiments	experiment	NNS
cord-015021-pol2qm74	2940	4	,	,	,
cord-015021-pol2qm74	2940	5	macrophages	macrophage	NNS
cord-015021-pol2qm74	2940	6	stimulated	stimulate	VBN
cord-015021-pol2qm74	2940	7	with	with	IN
cord-015021-pol2qm74	2940	8	recombinant	recombinant	JJ
cord-015021-pol2qm74	2940	9	mouse	mouse	NN
cord-015021-pol2qm74	2940	10	MIF	MIF	NNP
cord-015021-pol2qm74	2940	11	(	(	-LRB-
cord-015021-pol2qm74	2940	12	1	1	CD
cord-015021-pol2qm74	2940	13	gg	gg	NNP
cord-015021-pol2qm74	2940	14	/	/	SYM
cord-015021-pol2qm74	2940	15	ml	ml	NN
cord-015021-pol2qm74	2940	16	)	)	-RRB-
cord-015021-pol2qm74	2940	17	were	be	VBD
cord-015021-pol2qm74	2940	18	found	find	VBN
cord-015021-pol2qm74	2940	19	to	to	TO
cord-015021-pol2qm74	2940	20	secrete	secrete	VB
cord-015021-pol2qm74	2940	21	bioactive	bioactive	JJ
cord-015021-pol2qm74	2940	22	TNF~	tnf~	PRP
cord-015021-pol2qm74	2940	23	(	(	-LRB-
cord-015021-pol2qm74	2940	24	>	>	NFP
cord-015021-pol2qm74	2940	25	750	750	CD
cord-015021-pol2qm74	2940	26	pg	pg	NN
cord-015021-pol2qm74	2940	27	/	/	SYM
cord-015021-pol2qm74	2940	28	ml	ml	NNS
cord-015021-pol2qm74	2940	29	by	by	IN
cord-015021-pol2qm74	2940	30	L929	l929	CD
cord-015021-pol2qm74	2940	31	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	2940	32	)	)	-RRB-
cord-015021-pol2qm74	2940	33	.	.	.
cord-015021-pol2qm74	2941	1	We	-PRON-	PRP
cord-015021-pol2qm74	2941	2	conclude	conclude	VBP
cord-015021-pol2qm74	2941	3	that	that	IN
cord-015021-pol2qm74	2941	4	the	the	DT
cord-015021-pol2qm74	2941	5	macrophage	macrophage	NN
cord-015021-pol2qm74	2941	6	is	be	VBZ
cord-015021-pol2qm74	2941	7	an	an	DT
cord-015021-pol2qm74	2941	8	important	important	JJ
cord-015021-pol2qm74	2941	9	albeit	albeit	IN
cord-015021-pol2qm74	2941	10	overlooked	overlook	VBN
cord-015021-pol2qm74	2941	11	cellular	cellular	JJ
cord-015021-pol2qm74	2941	12	source	source	NN
cord-015021-pol2qm74	2941	13	of	of	IN
cord-015021-pol2qm74	2941	14	MIF	MIF	NNP
cord-015021-pol2qm74	2941	15	in	in	IN
cord-015021-pol2qm74	2941	16	vivo	vivo	NNP
cord-015021-pol2qm74	2941	17	.	.	.
cord-015021-pol2qm74	2942	1	MIF	MIF	NNP
cord-015021-pol2qm74	2942	2	secretion	secretion	NN
cord-015021-pol2qm74	2942	3	is	be	VBZ
cord-015021-pol2qm74	2942	4	induced	induce	VBN
cord-015021-pol2qm74	2942	5	by	by	IN
cord-015021-pol2qm74	2942	6	LPS	LPS	NNP
cord-015021-pol2qm74	2942	7	,	,	,
cord-015021-pol2qm74	2942	8	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	2942	9	and	and	CC
cord-015021-pol2qm74	2942	10	IFN	IFN	NNP
cord-015021-pol2qm74	2942	11	?	?	.
cord-015021-pol2qm74	2942	12	.	.	.
cord-015021-pol2qm74	2943	1	MIF	MIF	NNP
cord-015021-pol2qm74	2943	2	also	also	RB
cord-015021-pol2qm74	2943	3	stimulates	stimulate	VBZ
cord-015021-pol2qm74	2943	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	2943	5	to	to	TO
cord-015021-pol2qm74	2943	6	secrete	secrete	VB
cord-015021-pol2qm74	2943	7	TNF	TNF	NNP
cord-015021-pol2qm74	2943	8	.	.	.
cord-015021-pol2qm74	2944	1	Taken	take	VBN
cord-015021-pol2qm74	2944	2	together	together	RB
cord-015021-pol2qm74	2944	3	with	with	IN
cord-015021-pol2qm74	2944	4	previous	previous	JJ
cord-015021-pol2qm74	2944	5	observations	observation	NNS
cord-015021-pol2qm74	2944	6	that	that	IN
cord-015021-pol2qm74	2944	7	anti	anti	JJ
cord-015021-pol2qm74	2944	8	-	-	JJ
cord-015021-pol2qm74	2944	9	MIF	mif	JJ
cord-015021-pol2qm74	2944	10	antibody	antibody	NN
cord-015021-pol2qm74	2944	11	protects	protect	VBZ
cord-015021-pol2qm74	2944	12	against	against	IN
cord-015021-pol2qm74	2944	13	lethal	lethal	JJ
cord-015021-pol2qm74	2944	14	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	2944	15	,	,	,
cord-015021-pol2qm74	2944	16	these	these	DT
cord-015021-pol2qm74	2944	17	data	datum	NNS
cord-015021-pol2qm74	2944	18	implicate	implicate	VBP
cord-015021-pol2qm74	2944	19	MIF	MIF	NNP
cord-015021-pol2qm74	2944	20	as	as	IN
cord-015021-pol2qm74	2944	21	a	a	DT
cord-015021-pol2qm74	2944	22	critical	critical	JJ
cord-015021-pol2qm74	2944	23	mediator	mediator	NN
cord-015021-pol2qm74	2944	24	of	of	IN
cord-015021-pol2qm74	2944	25	inflammation	inflammation	NN
cord-015021-pol2qm74	2944	26	and	and	CC
cord-015021-pol2qm74	2944	27	septic	septic	JJ
cord-015021-pol2qm74	2944	28	shock	shock	NN
cord-015021-pol2qm74	2944	29	.	.	.
cord-015021-pol2qm74	2945	1	Inflammation	inflammation	NN
cord-015021-pol2qm74	2945	2	is	be	VBZ
cord-015021-pol2qm74	2945	3	characterized	characterize	VBN
cord-015021-pol2qm74	2945	4	by	by	IN
cord-015021-pol2qm74	2945	5	an	an	DT
cord-015021-pol2qm74	2945	6	exacerbation	exacerbation	NN
cord-015021-pol2qm74	2945	7	of	of	IN
cord-015021-pol2qm74	2945	8	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	2945	9	cytokine	cytokine	NN
cord-015021-pol2qm74	2945	10	production	production	NN
cord-015021-pol2qm74	2945	11	.	.	.
cord-015021-pol2qm74	2946	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	2946	2	such	such	JJ
cord-015021-pol2qm74	2946	3	as	as	IN
cord-015021-pol2qm74	2946	4	IL-4	IL-4	NNP
cord-015021-pol2qm74	2946	5	,	,	,
cord-015021-pol2qm74	2946	6	IL-10	IL-10	NNP
cord-015021-pol2qm74	2946	7	,	,	,
cord-015021-pol2qm74	2946	8	and	and	CC
cord-015021-pol2qm74	2946	9	TGF8	TGF8	NNP
cord-015021-pol2qm74	2946	10	,	,	,
cord-015021-pol2qm74	2946	11	have	have	VBP
cord-015021-pol2qm74	2946	12	been	be	VBN
cord-015021-pol2qm74	2946	13	identified	identify	VBN
cord-015021-pol2qm74	2946	14	as	as	IN
cord-015021-pol2qm74	2946	15	anti	anti	JJ
cord-015021-pol2qm74	2946	16	-	-	JJ
cord-015021-pol2qm74	2946	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2946	18	mediators	mediator	NNS
cord-015021-pol2qm74	2946	19	thanks	thank	NNS
cord-015021-pol2qm74	2946	20	to	to	IN
cord-015021-pol2qm74	2946	21	their	-PRON-	PRP$
cord-015021-pol2qm74	2946	22	ability	ability	NN
cord-015021-pol2qm74	2946	23	to	to	TO
cord-015021-pol2qm74	2946	24	down	down	RB
cord-015021-pol2qm74	2946	25	regulate	regulate	VB
cord-015021-pol2qm74	2946	26	the	the	DT
cord-015021-pol2qm74	2946	27	production	production	NN
cord-015021-pol2qm74	2946	28	of	of	IN
cord-015021-pol2qm74	2946	29	IL-1	IL-1	NNP
cord-015021-pol2qm74	2946	30	,	,	,
cord-015021-pol2qm74	2946	31	IL-6	IL-6	NNP
cord-015021-pol2qm74	2946	32	,	,	,
cord-015021-pol2qm74	2947	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	2947	2	,	,	,
cord-015021-pol2qm74	2947	3	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	2947	4	by	by	IN
cord-015021-pol2qm74	2947	5	activated	activate	VBN
cord-015021-pol2qm74	2947	6	monocytes	monocyte	NNS
cord-015021-pol2qm74	2947	7	/	/	SYM
cord-015021-pol2qm74	2947	8	macrophages	macrophage	NNS
cord-015021-pol2qm74	2947	9	.	.	.
cord-015021-pol2qm74	2948	1	However	however	RB
cord-015021-pol2qm74	2948	2	,	,	,
cord-015021-pol2qm74	2948	3	other	other	JJ
cord-015021-pol2qm74	2948	4	cells	cell	NNS
cord-015021-pol2qm74	2948	5	,	,	,
cord-015021-pol2qm74	2948	6	including	include	VBG
cord-015021-pol2qm74	2948	7	polymorphonuclear	polymorphonuclear	NN
cord-015021-pol2qm74	2948	8	cells	cell	NNS
cord-015021-pol2qm74	2948	9	(	(	-LRB-
cord-015021-pol2qm74	2948	10	PMN	pmn	NN
cord-015021-pol2qm74	2948	11	)	)	-RRB-
cord-015021-pol2qm74	2948	12	do	do	VBP
cord-015021-pol2qm74	2948	13	contribute	contribute	VB
cord-015021-pol2qm74	2948	14	to	to	IN
cord-015021-pol2qm74	2948	15	the	the	DT
cord-015021-pol2qm74	2948	16	release	release	NN
cord-015021-pol2qm74	2948	17	of	of	IN
cord-015021-pol2qm74	2948	18	pro	pro	JJ
cord-015021-pol2qm74	2948	19	-	-	JJ
cord-015021-pol2qm74	2948	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2948	21	cytokines	cytokine	NNS
cord-015021-pol2qm74	2948	22	.	.	.
cord-015021-pol2qm74	2949	1	We	-PRON-	PRP
cord-015021-pol2qm74	2949	2	investigated	investigate	VBD
cord-015021-pol2qm74	2949	3	the	the	DT
cord-015021-pol2qm74	2949	4	capacity	capacity	NN
cord-015021-pol2qm74	2949	5	of	of	IN
cord-015021-pol2qm74	2949	6	the	the	DT
cord-015021-pol2qm74	2949	7	so	so	RB
cord-015021-pol2qm74	2949	8	-	-	HYPH
cord-015021-pol2qm74	2949	9	called	call	VBN
cord-015021-pol2qm74	2949	10	anti	anti	JJ
cord-015021-pol2qm74	2949	11	-	-	JJ
cord-015021-pol2qm74	2949	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	2949	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	2949	14	to	to	TO
cord-015021-pol2qm74	2949	15	control	control	VB
cord-015021-pol2qm74	2949	16	the	the	DT
cord-015021-pol2qm74	2949	17	release	release	NN
cord-015021-pol2qm74	2949	18	of	of	IN
cord-015021-pol2qm74	2949	19	IL-8	IL-8	NNP
cord-015021-pol2qm74	2949	20	by	by	IN
cord-015021-pol2qm74	2949	21	activated	activate	VBN
cord-015021-pol2qm74	2949	22	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	2949	23	.	.	.
cord-015021-pol2qm74	2950	1	Human	Human	NNP
cord-015021-pol2qm74	2950	2	PMN	PMN	NNP
cord-015021-pol2qm74	2950	3	were	be	VBD
cord-015021-pol2qm74	2950	4	purified	purify	VBN
cord-015021-pol2qm74	2950	5	following	follow	VBG
cord-015021-pol2qm74	2950	6	glucose	glucose	NN
cord-015021-pol2qm74	2950	7	-	-	HYPH
cord-015021-pol2qm74	2950	8	dextran	dextran	NN
cord-015021-pol2qm74	2950	9	sedimentation	sedimentation	NN
cord-015021-pol2qm74	2950	10	and	and	CC
cord-015021-pol2qm74	2950	11	FicolI	ficoli	RB
cord-015021-pol2qm74	2950	12	-	-	HYPH
cord-015021-pol2qm74	2950	13	Hypaque	hypaque	NN
cord-015021-pol2qm74	2950	14	centrifugation	centrifugation	NN
cord-015021-pol2qm74	2950	15	.	.	.
cord-015021-pol2qm74	2951	1	The	the	DT
cord-015021-pol2qm74	2951	2	cells	cell	NNS
cord-015021-pol2qm74	2951	3	were	be	VBD
cord-015021-pol2qm74	2951	4	cultured	culture	VBN
cord-015021-pol2qm74	2951	5	at	at	IN
cord-015021-pol2qm74	2951	6	37	37	CD
cord-015021-pol2qm74	2951	7	°	°	NN
cord-015021-pol2qm74	2951	8	C	c	NN
cord-015021-pol2qm74	2951	9	for	for	IN
cord-015021-pol2qm74	2951	10	24h	24h	NNS
cord-015021-pol2qm74	2951	11	in	in	IN
cord-015021-pol2qm74	2951	12	the	the	DT
cord-015021-pol2qm74	2951	13	absence	absence	NN
cord-015021-pol2qm74	2951	14	or	or	CC
cord-015021-pol2qm74	2951	15	presence	presence	NN
cord-015021-pol2qm74	2951	16	of	of	IN
cord-015021-pol2qm74	2951	17	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	2951	18	(	(	-LRB-
cord-015021-pol2qm74	2951	19	LPS	LPS	NNP
cord-015021-pol2qm74	2951	20	)	)	-RRB-
cord-015021-pol2qm74	2951	21	or	or	CC
cord-015021-pol2qm74	2951	22	TNFa	TNFa	NNS
cord-015021-pol2qm74	2951	23	.	.	.
cord-015021-pol2qm74	2952	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	2952	2	release	release	NN
cord-015021-pol2qm74	2952	3	was	be	VBD
cord-015021-pol2qm74	2952	4	measured	measure	VBN
cord-015021-pol2qm74	2952	5	in	in	IN
cord-015021-pol2qm74	2952	6	the	the	DT
cord-015021-pol2qm74	2952	7	supernatants	supernatant	NNS
cord-015021-pol2qm74	2952	8	using	use	VBG
cord-015021-pol2qm74	2952	9	a	a	DT
cord-015021-pol2qm74	2952	10	specific	specific	JJ
cord-015021-pol2qm74	2952	11	ELISA	ELISA	NNP
cord-015021-pol2qm74	2952	12	.	.	.
cord-015021-pol2qm74	2953	1	Among	among	IN
cord-015021-pol2qm74	2953	2	tested	test	VBN
cord-015021-pol2qm74	2953	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	2953	4	,	,	,
cord-015021-pol2qm74	2953	5	IL-10	IL-10	NNP
cord-015021-pol2qm74	2953	6	was	be	VBD
cord-015021-pol2qm74	2953	7	the	the	DT
cord-015021-pol2qm74	2953	8	most	most	RBS
cord-015021-pol2qm74	2953	9	efficient	efficient	JJ
cord-015021-pol2qm74	2953	10	inhibitor	inhibitor	NN
cord-015021-pol2qm74	2953	11	of	of	IN
cord-015021-pol2qm74	2953	12	IL-8	IL-8	NNP
cord-015021-pol2qm74	2953	13	production	production	NN
cord-015021-pol2qm74	2953	14	by	by	IN
cord-015021-pol2qm74	2953	15	LPS	LPS	NNP
cord-015021-pol2qm74	2953	16	-	-	HYPH
cord-015021-pol2qm74	2953	17	activated	activate	VBN
cord-015021-pol2qm74	2953	18	PMN	PMN	NNP
cord-015021-pol2qm74	2953	19	.	.	.
cord-015021-pol2qm74	2954	1	IL-4	IL-4	NNP
cord-015021-pol2qm74	2954	2	was	be	VBD
cord-015021-pol2qm74	2954	3	also	also	RB
cord-015021-pol2qm74	2954	4	active	active	JJ
cord-015021-pol2qm74	2954	5	,	,	,
cord-015021-pol2qm74	2954	6	whereas	whereas	IN
cord-015021-pol2qm74	2954	7	no	no	DT
cord-015021-pol2qm74	2954	8	down	down	JJ
cord-015021-pol2qm74	2954	9	regulation	regulation	NN
cord-015021-pol2qm74	2954	10	was	be	VBD
cord-015021-pol2qm74	2954	11	noticed	notice	VBN
cord-015021-pol2qm74	2954	12	with	with	IN
cord-015021-pol2qm74	2954	13	TGFP	TGFP	NNP
cord-015021-pol2qm74	2954	14	~	~	NFP
cord-015021-pol2qm74	2954	15	I.	i.	NN
cord-015021-pol2qm74	2955	1	When	when	WRB
cord-015021-pol2qm74	2955	2	TNFa	TNFa	NNP
cord-015021-pol2qm74	2955	3	was	be	VBD
cord-015021-pol2qm74	2955	4	used	use	VBN
cord-015021-pol2qm74	2955	5	as	as	IN
cord-015021-pol2qm74	2955	6	a	a	DT
cord-015021-pol2qm74	2955	7	triggering	trigger	VBG
cord-015021-pol2qm74	2955	8	agent	agent	NN
cord-015021-pol2qm74	2955	9	,	,	,
cord-015021-pol2qm74	2955	10	none	none	NN
cord-015021-pol2qm74	2955	11	of	of	IN
cord-015021-pol2qm74	2955	12	the	the	DT
cord-015021-pol2qm74	2955	13	cytokine	cytokine	NN
cord-015021-pol2qm74	2955	14	could	could	MD
cord-015021-pol2qm74	2955	15	prevent	prevent	VB
cord-015021-pol2qm74	2955	16	IL-8	il-8	NN
cord-015021-pol2qm74	2955	17	production	production	NN
cord-015021-pol2qm74	2955	18	.	.	.
cord-015021-pol2qm74	2956	1	Northern	northern	JJ
cord-015021-pol2qm74	2956	2	analysis	analysis	NN
cord-015021-pol2qm74	2956	3	are	be	VBP
cord-015021-pol2qm74	2956	4	under	under	IN
cord-015021-pol2qm74	2956	5	investigation	investigation	NN
cord-015021-pol2qm74	2956	6	to	to	TO
cord-015021-pol2qm74	2956	7	precise	precise	VB
cord-015021-pol2qm74	2956	8	the	the	DT
cord-015021-pol2qm74	2956	9	level	level	NN
cord-015021-pol2qm74	2956	10	of	of	IN
cord-015021-pol2qm74	2956	11	the	the	DT
cord-015021-pol2qm74	2956	12	IL-4-and	IL-4-and	NNP
cord-015021-pol2qm74	2956	13	IL-10-induced	il-10-induced	JJ
cord-015021-pol2qm74	2956	14	inhibition	inhibition	NN
cord-015021-pol2qm74	2956	15	of	of	IN
cord-015021-pol2qm74	2956	16	IL-8	il-8	NN
cord-015021-pol2qm74	2956	17	production	production	NN
cord-015021-pol2qm74	2956	18	by	by	IN
cord-015021-pol2qm74	2956	19	PMN	PMN	NNP
cord-015021-pol2qm74	2956	20	.	.	.
cord-015021-pol2qm74	2957	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2957	2	data	datum	NNS
cord-015021-pol2qm74	2957	3	illustrate	illustrate	VBP
cord-015021-pol2qm74	2957	4	that	that	IN
cord-015021-pol2qm74	2957	5	IL-10	IL-10	NNP
cord-015021-pol2qm74	2957	6	and	and	CC
cord-015021-pol2qm74	2957	7	IL-4	IL-4	NNP
cord-015021-pol2qm74	2957	8	possess	possess	VBP
cord-015021-pol2qm74	2957	9	the	the	DT
cord-015021-pol2qm74	2957	10	capacity	capacity	NN
cord-015021-pol2qm74	2957	11	to	to	TO
cord-015021-pol2qm74	2957	12	down	down	RB
cord-015021-pol2qm74	2957	13	regulate	regulate	VB
cord-015021-pol2qm74	2957	14	the	the	DT
cord-015021-pol2qm74	2957	15	production	production	NN
cord-015021-pol2qm74	2957	16	of	of	IN
cord-015021-pol2qm74	2957	17	IL-8	IL-8	NNP
cord-015021-pol2qm74	2957	18	by	by	IN
cord-015021-pol2qm74	2957	19	both	both	DT
cord-015021-pol2qm74	2957	20	monocytes	monocyte	NNS
cord-015021-pol2qm74	2957	21	and	and	CC
cord-015021-pol2qm74	2957	22	PMN	PMN	NNP
cord-015021-pol2qm74	2957	23	,	,	,
cord-015021-pol2qm74	2957	24	whereas	whereas	IN
cord-015021-pol2qm74	2957	25	TGFB	TGFB	NNP
cord-015021-pol2qm74	2957	26	has	have	VBZ
cord-015021-pol2qm74	2957	27	a	a	DT
cord-015021-pol2qm74	2957	28	more	more	RBR
cord-015021-pol2qm74	2957	29	limited	limited	JJ
cord-015021-pol2qm74	2957	30	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	2957	31	activity	activity	NN
cord-015021-pol2qm74	2957	32	.	.	.
cord-015021-pol2qm74	2958	1	Ciliary	ciliary	JJ
cord-015021-pol2qm74	2958	2	neurotrophic	neurotrophic	NN
cord-015021-pol2qm74	2958	3	factor	factor	NN
cord-015021-pol2qm74	2958	4	(	(	-LRB-
cord-015021-pol2qm74	2958	5	CNTF	CNTF	NNP
cord-015021-pol2qm74	2958	6	)	)	-RRB-
cord-015021-pol2qm74	2958	7	,	,	,
cord-015021-pol2qm74	2958	8	a	a	DT
cord-015021-pol2qm74	2958	9	member	member	NN
cord-015021-pol2qm74	2958	10	of	of	IN
cord-015021-pol2qm74	2958	11	the	the	DT
cord-015021-pol2qm74	2958	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	2958	13	superfamily	superfamily	NN
cord-015021-pol2qm74	2958	14	,	,	,
cord-015021-pol2qm74	2958	15	has	have	VBZ
cord-015021-pol2qm74	2958	16	recently	recently	RB
cord-015021-pol2qm74	2958	17	been	be	VBN
cord-015021-pol2qm74	2958	18	shown	show	VBN
cord-015021-pol2qm74	2958	19	to	to	TO
cord-015021-pol2qm74	2958	20	promote	promote	VB
cord-015021-pol2qm74	2958	21	axonal	axonal	JJ
cord-015021-pol2qm74	2958	22	growth	growth	NN
cord-015021-pol2qm74	2958	23	and	and	CC
cord-015021-pol2qm74	2958	24	neuronal	neuronal	JJ
cord-015021-pol2qm74	2958	25	healing	healing	NN
cord-015021-pol2qm74	2958	26	.	.	.
cord-015021-pol2qm74	2959	1	CNTF	cntf	NN
cord-015021-pol2qm74	2959	2	production	production	NN
cord-015021-pol2qm74	2959	3	is	be	VBZ
cord-015021-pol2qm74	2959	4	also	also	RB
cord-015021-pol2qm74	2959	5	increased	increase	VBN
cord-015021-pol2qm74	2959	6	during	during	IN
cord-015021-pol2qm74	2959	7	neuronal	neuronal	JJ
cord-015021-pol2qm74	2959	8	and	and	CC
cord-015021-pol2qm74	2959	9	muscle	muscle	NN
cord-015021-pol2qm74	2959	10	damage	damage	NN
cord-015021-pol2qm74	2959	11	,	,	,
cord-015021-pol2qm74	2959	12	associated	associate	VBN
cord-015021-pol2qm74	2959	13	with	with	IN
cord-015021-pol2qm74	2959	14	soft	soft	JJ
cord-015021-pol2qm74	2959	15	tissue	tissue	NN
cord-015021-pol2qm74	2959	16	injury	injury	NN
cord-015021-pol2qm74	2959	17	or	or	CC
cord-015021-pol2qm74	2959	18	trauma	trauma	NN
cord-015021-pol2qm74	2959	19	.	.	.
cord-015021-pol2qm74	2960	1	We	-PRON-	PRP
cord-015021-pol2qm74	2960	2	postulated	postulate	VBD
cord-015021-pol2qm74	2960	3	that	that	IN
cord-015021-pol2qm74	2960	4	production	production	NN
cord-015021-pol2qm74	2960	5	of	of	IN
cord-015021-pol2qm74	2960	6	CNTF	CNTF	NNP
cord-015021-pol2qm74	2960	7	may	may	MD
cord-015021-pol2qm74	2960	8	explain	explain	VB
cord-015021-pol2qm74	2960	9	the	the	DT
cord-015021-pol2qm74	2960	10	loss	loss	NN
cord-015021-pol2qm74	2960	11	of	of	IN
cord-015021-pol2qm74	2960	12	skeletal	skeletal	JJ
cord-015021-pol2qm74	2960	13	muscM	muscM	NNP
cord-015021-pol2qm74	2960	14	protein	protein	NN
cord-015021-pol2qm74	2960	15	that	that	WDT
cord-015021-pol2qm74	2960	16	occurs	occur	VBZ
cord-015021-pol2qm74	2960	17	in	in	IN
cord-015021-pol2qm74	2960	18	inflammation	inflammation	NN
cord-015021-pol2qm74	2960	19	.	.	.
cord-015021-pol2qm74	2961	1	40	40	CD
cord-015021-pol2qm74	2961	2	female	female	NN
cord-015021-pol2qm74	2961	3	,	,	,
cord-015021-pol2qm74	2961	4	Wistar	Wistar	NNP
cord-015021-pol2qm74	2961	5	(	(	-LRB-
cord-015021-pol2qm74	2961	6	175	175	CD
cord-015021-pol2qm74	2961	7	-	-	SYM
cord-015021-pol2qm74	2961	8	200	200	CD
cord-015021-pol2qm74	2961	9	gm	gm	NNP
cord-015021-pol2qm74	2961	10	)	)	-RRB-
cord-015021-pol2qm74	2961	11	rats	rat	NNS
cord-015021-pol2qm74	2961	12	received	receive	VBD
cord-015021-pol2qm74	2961	13	either	either	CC
cord-015021-pol2qm74	2961	14	250	250	CD
cord-015021-pol2qm74	2961	15	or	or	CC
cord-015021-pol2qm74	2961	16	25	25	CD
cord-015021-pol2qm74	2961	17	pg	pg	NN
cord-015021-pol2qm74	2961	18	/	/	SYM
cord-015021-pol2qm74	2961	19	kg	kg	NNP
cord-015021-pol2qm74	2961	20	BW	BW	NNP
cord-015021-pol2qm74	2961	21	s.c	s.c	NNP
cord-015021-pol2qm74	2961	22	.	.	.
cord-015021-pol2qm74	2961	23	injections	injection	NNS
cord-015021-pol2qm74	2961	24	of	of	IN
cord-015021-pol2qm74	2961	25	recombinant	recombinant	JJ
cord-015021-pol2qm74	2961	26	rat	rat	NN
cord-015021-pol2qm74	2961	27	CNTF	CNTF	NNP
cord-015021-pol2qm74	2961	28	for	for	IN
cord-015021-pol2qm74	2961	29	seven	seven	CD
cord-015021-pol2qm74	2961	30	days	day	NNS
cord-015021-pol2qm74	2961	31	,	,	,
cord-015021-pol2qm74	2961	32	or	or	CC
cord-015021-pol2qm74	2961	33	received	receive	VBD
cord-015021-pol2qm74	2961	34	sham	sham	JJ
cord-015021-pol2qm74	2961	35	injections	injection	NNS
cord-015021-pol2qm74	2961	36	and	and	CC
cord-015021-pol2qm74	2961	37	were	be	VBD
cord-015021-pol2qm74	2961	38	freely	freely	RB
cord-015021-pol2qm74	2961	39	-	-	HYPH
cord-015021-pol2qm74	2961	40	fed	feed	VBN
cord-015021-pol2qm74	2961	41	.	.	.
cord-015021-pol2qm74	2962	1	Additional	additional	JJ
cord-015021-pol2qm74	2962	2	animals	animal	NNS
cord-015021-pol2qm74	2962	3	were	be	VBD
cord-015021-pol2qm74	2962	4	pretreated	pretreate	VBN
cord-015021-pol2qm74	2962	5	with	with	IN
cord-015021-pol2qm74	2962	6	10	10	CD
cord-015021-pol2qm74	2962	7	mg	mg	NNP
cord-015021-pol2qm74	2962	8	/	/	SYM
cord-015021-pol2qm74	2962	9	kg	kg	NNP
cord-015021-pol2qm74	2962	10	ibuprofen	ibuprofen	NNP
cord-015021-pol2qm74	2962	11	Lp	Lp	NNP
cord-015021-pol2qm74	2962	12	prior	prior	RB
cord-015021-pol2qm74	2962	13	to	to	IN
cord-015021-pol2qm74	2962	14	250	250	CD
cord-015021-pol2qm74	2962	15	pg	pg	NN
cord-015021-pol2qm74	2962	16	/	/	SYM
cord-015021-pol2qm74	2962	17	kg	kg	NNP
cord-015021-pol2qm74	2962	18	BW	BW	NNP
cord-015021-pol2qm74	2962	19	CNTF	CNTF	NNP
cord-015021-pol2qm74	2962	20	.	.	.
cord-015021-pol2qm74	2963	1	Rats	rat	NNS
cord-015021-pol2qm74	2963	2	treated	treat	VBN
cord-015021-pol2qm74	2963	3	with	with	IN
cord-015021-pol2qm74	2963	4	250	250	CD
cord-015021-pol2qm74	2963	5	,	,	,
cord-015021-pol2qm74	2963	6	ug	ug	NNP
cord-015021-pol2qm74	2963	7	/	/	SYM
cord-015021-pol2qm74	2963	8	kg	kg	NNP
cord-015021-pol2qm74	2963	9	BW	BW	NNP
cord-015021-pol2qm74	2963	10	CNTF	CNTF	NNP
cord-015021-pol2qm74	2963	11	lost	lose	VBD
cord-015021-pol2qm74	2963	12	6.8_+0.4	6.8_+0.4	CD
cord-015021-pol2qm74	2963	13	gms	gms	NNP
cord-015021-pol2qm74	2963	14	BW	BW	NNP
cord-015021-pol2qm74	2963	15	as	as	IN
cord-015021-pol2qm74	2963	16	compared	compare	VBN
cord-015021-pol2qm74	2963	17	to	to	IN
cord-015021-pol2qm74	2963	18	freely	freely	RB
cord-015021-pol2qm74	2963	19	-	-	HYPH
cord-015021-pol2qm74	2963	20	fed	feed	VBN
cord-015021-pol2qm74	2963	21	controls	control	NNS
cord-015021-pol2qm74	2963	22	which	which	WDT
cord-015021-pol2qm74	2963	23	gained	gain	VBD
cord-015021-pol2qm74	2963	24	17.0_+3.1	17.0_+3.1	CD
cord-015021-pol2qm74	2963	25	gms	gms	NNP
cord-015021-pol2qm74	2963	26	(	(	-LRB-
cord-015021-pol2qm74	2963	27	p	p	NN
cord-015021-pol2qm74	2963	28	<	<	XX
cord-015021-pol2qm74	2963	29	O.001	o.001	XX
cord-015021-pol2qm74	2963	30	by	by	IN
cord-015021-pol2qm74	2963	31	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	2963	32	and	and	CC
cord-015021-pol2qm74	2963	33	LSD	LSD	NNP
cord-015021-pol2qm74	2963	34	)	)	-RRB-
cord-015021-pol2qm74	2963	35	,	,	,
cord-015021-pol2qm74	2963	36	and	and	CC
cord-015021-pol2qm74	2963	37	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	2963	38	treatment	treatment	NN
cord-015021-pol2qm74	2963	39	had	have	VBD
cord-015021-pol2qm74	2963	40	no	no	DT
cord-015021-pol2qm74	2963	41	effect	effect	NN
cord-015021-pol2qm74	2963	42	on	on	IN
cord-015021-pol2qm74	2963	43	CNTF	CNTF	NNP
cord-015021-pol2qm74	2963	44	-	-	HYPH
cord-015021-pol2qm74	2963	45	induced	induce	VBN
cord-015021-pol2qm74	2963	46	weight	weight	NN
cord-015021-pol2qm74	2963	47	loss	loss	NN
cord-015021-pol2qm74	2963	48	(	(	-LRB-
cord-015021-pol2qm74	2963	49	-5.8_+0.7	-5.8_+0.7	NN
cord-015021-pol2qm74	2963	50	)	)	-RRB-
cord-015021-pol2qm74	2963	51	.	.	.
cord-015021-pol2qm74	2964	1	Animals	animal	NNS
cord-015021-pol2qm74	2964	2	pair	pair	VBP
cord-015021-pol2qm74	2964	3	fed	feed	VBN
cord-015021-pol2qm74	2964	4	to	to	IN
cord-015021-pol2qm74	2964	5	the	the	DT
cord-015021-pol2qm74	2964	6	high	high	JJ
cord-015021-pol2qm74	2964	7	dose	dose	NN
cord-015021-pol2qm74	2965	1	CNTF	CNTF	NNP
cord-015021-pol2qm74	2965	2	gained	gain	VBD
cord-015021-pol2qm74	2965	3	body	body	NN
cord-015021-pol2qm74	2965	4	weight	weight	NN
cord-015021-pol2qm74	2965	5	(	(	-LRB-
cord-015021-pol2qm74	2965	6	10.2-+3.5	10.2-+3.5	CD
cord-015021-pol2qm74	2965	7	)	)	-RRB-
cord-015021-pol2qm74	2965	8	,	,	,
cord-015021-pol2qm74	2965	9	although	although	IN
cord-015021-pol2qm74	2965	10	weight	weight	NN
cord-015021-pol2qm74	2965	11	gain	gain	NN
cord-015021-pol2qm74	2965	12	was	be	VBD
cord-015021-pol2qm74	2965	13	less	less	JJR
cord-015021-pol2qm74	2965	14	than	than	IN
cord-015021-pol2qm74	2965	15	seen	see	VBN
cord-015021-pol2qm74	2965	16	in	in	IN
cord-015021-pol2qm74	2965	17	freely	freely	RB
cord-015021-pol2qm74	2965	18	-	-	HYPH
cord-015021-pol2qm74	2965	19	fed	feed	VBN
cord-015021-pol2qm74	2965	20	controls	control	NNS
cord-015021-pol2qm74	2965	21	.	.	.
cord-015021-pol2qm74	2966	1	Rats	rat	NNS
cord-015021-pol2qm74	2966	2	treated	treat	VBN
cord-015021-pol2qm74	2966	3	with	with	IN
cord-015021-pol2qm74	2966	4	25	25	CD
cord-015021-pol2qm74	2966	5	pg	pg	NN
cord-015021-pol2qm74	2966	6	/	/	SYM
cord-015021-pol2qm74	2966	7	kg	kg	NNP
cord-015021-pol2qm74	2967	1	BW	BW	NNP
cord-015021-pol2qm74	2967	2	had	have	VBD
cord-015021-pol2qm74	2967	3	reduced	reduce	VBN
cord-015021-pol2qm74	2967	4	body	body	NN
cord-015021-pol2qm74	2967	5	weight	weight	NN
cord-015021-pol2qm74	2967	6	gain	gain	NN
cord-015021-pol2qm74	2967	7	(	(	-LRB-
cord-015021-pol2qm74	2967	8	+7.8+_4.4	+7.8+_4.4	NFP
cord-015021-pol2qm74	2967	9	gin	gin	NN
cord-015021-pol2qm74	2967	10	)	)	-RRB-
cord-015021-pol2qm74	2967	11	.	.	.
cord-015021-pol2qm74	2968	1	Food	food	NN
cord-015021-pol2qm74	2968	2	intake	intake	NN
cord-015021-pol2qm74	2968	3	was	be	VBD
cord-015021-pol2qm74	2968	4	also	also	RB
cord-015021-pol2qm74	2968	5	reduced	reduce	VBN
cord-015021-pol2qm74	2968	6	by	by	IN
cord-015021-pol2qm74	2968	7	29	29	CD
cord-015021-pol2qm74	2968	8	%	%	NN
cord-015021-pol2qm74	2968	9	in	in	IN
cord-015021-pol2qm74	2968	10	250	250	CD
cord-015021-pol2qm74	2968	11	pg	pg	NN
cord-015021-pol2qm74	2968	12	/	/	SYM
cord-015021-pol2qm74	2968	13	kg	kg	NNP
cord-015021-pol2qm74	2968	14	CNTF	CNTF	NNP
cord-015021-pol2qm74	2968	15	(	(	-LRB-
cord-015021-pol2qm74	2968	16	from	from	IN
cord-015021-pol2qm74	2968	17	23.7+_0.7	23.7+_0.7	CD
cord-015021-pol2qm74	2968	18	gm	gm	NNP
cord-015021-pol2qm74	2968	19	/	/	SYM
cord-015021-pol2qm74	2968	20	day	day	NN
cord-015021-pol2qm74	2968	21	to	to	IN
cord-015021-pol2qm74	2968	22	16.8_+0.6	16.8_+0.6	CD
cord-015021-pol2qm74	2968	23	gm	gm	NNP
cord-015021-pol2qm74	2968	24	/	/	SYM
cord-015021-pol2qm74	2968	25	day	day	NN
cord-015021-pol2qm74	2968	26	;	;	:
cord-015021-pol2qm74	2968	27	p	p	NN
cord-015021-pol2qm74	2968	28	<	<	XX
cord-015021-pol2qm74	2968	29	O.05	o.05	NN
cord-015021-pol2qm74	2968	30	)	)	-RRB-
cord-015021-pol2qm74	2968	31	and	and	CC
cord-015021-pol2qm74	2968	32	was	be	VBD
cord-015021-pol2qm74	2968	33	also	also	RB
cord-015021-pol2qm74	2968	34	unaffected	unaffected	JJ
cord-015021-pol2qm74	2968	35	by	by	IN
cord-015021-pol2qm74	2968	36	prior	prior	JJ
cord-015021-pol2qm74	2968	37	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	2968	38	treatment	treatment	NN
cord-015021-pol2qm74	2968	39	(	(	-LRB-
cord-015021-pol2qm74	2968	40	18.4	18.4	CD
cord-015021-pol2qm74	2968	41	+	+	SYM
cord-015021-pol2qm74	2968	42	-0.6	-0.6	CD
cord-015021-pol2qm74	2968	43	gm	gm	NNP
cord-015021-pol2qm74	2968	44	/	/	SYM
cord-015021-pol2qm74	2968	45	day	day	NN
cord-015021-pol2qm74	2968	46	)	)	-RRB-
cord-015021-pol2qm74	2968	47	.	.	.
cord-015021-pol2qm74	2969	1	Despite	despite	IN
cord-015021-pol2qm74	2969	2	the	the	DT
cord-015021-pol2qm74	2969	3	loss	loss	NN
cord-015021-pol2qm74	2969	4	in	in	IN
cord-015021-pol2qm74	2969	5	body	body	NN
cord-015021-pol2qm74	2969	6	weight	weight	NN
cord-015021-pol2qm74	2969	7	noted	note	VBN
cord-015021-pol2qm74	2969	8	in	in	IN
cord-015021-pol2qm74	2969	9	the	the	DT
cord-015021-pol2qm74	2969	10	high	high	JJ
cord-015021-pol2qm74	2969	11	dose	dose	NN
cord-015021-pol2qm74	2969	12	CNTF	CNTF	NNP
cord-015021-pol2qm74	2969	13	animals	animal	NNS
cord-015021-pol2qm74	2969	14	,	,	,
cord-015021-pol2qm74	2969	15	there	there	EX
cord-015021-pol2qm74	2969	16	was	be	VBD
cord-015021-pol2qm74	2969	17	no	no	DT
cord-015021-pol2qm74	2969	18	appreciable	appreciable	JJ
cord-015021-pol2qm74	2969	19	hepatic	hepatic	JJ
cord-015021-pol2qm74	2969	20	acute	acute	JJ
cord-015021-pol2qm74	2969	21	phase	phase	NN
cord-015021-pol2qm74	2969	22	response	response	NN
cord-015021-pol2qm74	2969	23	,	,	,
cord-015021-pol2qm74	2969	24	since	since	IN
cord-015021-pol2qm74	2969	25	liver	liver	NN
cord-015021-pol2qm74	2969	26	weight	weight	NN
cord-015021-pol2qm74	2969	27	(	(	-LRB-
cord-015021-pol2qm74	2969	28	8.6	8.6	CD
cord-015021-pol2qm74	2969	29	+	+	SYM
cord-015021-pol2qm74	2969	30	0,1	0,1	CD
cord-015021-pol2qm74	2969	31	gms	gms	NN
cord-015021-pol2qm74	2969	32	vs.	vs.	FW
cord-015021-pol2qm74	2969	33	9.4_+0.3	9.4_+0.3	CD
cord-015021-pol2qm74	2969	34	gins	gin	NNS
cord-015021-pol2qm74	2969	35	)	)	-RRB-
cord-015021-pol2qm74	2969	36	,	,	,
cord-015021-pol2qm74	2969	37	total	total	JJ
cord-015021-pol2qm74	2969	38	protein	protein	NN
cord-015021-pol2qm74	2969	39	(	(	-LRB-
cord-015021-pol2qm74	2969	40	54.5	54.5	CD
cord-015021-pol2qm74	2969	41	+	+	SYM
cord-015021-pol2qm74	2969	42	-2.9	-2.9	CD
cord-015021-pol2qm74	2969	43	gms	gms	NNP
cord-015021-pol2qm74	2969	44	/	/	SYM
cord-015021-pol2qm74	2969	45	L	l	NN
cord-015021-pol2qm74	2969	46	vs	vs	IN
cord-015021-pol2qm74	2969	47	44.8	44.8	CD
cord-015021-pol2qm74	2969	48	+	+	CC
cord-015021-pol2qm74	2969	49	-3.6	-3.6	NNP
cord-015021-pol2qm74	2969	50	gins	gin	NNS
cord-015021-pol2qm74	2969	51	/	/	SYM
cord-015021-pol2qm74	2969	52	L	L	NNP
cord-015021-pol2qm74	2969	53	)	)	-RRB-
cord-015021-pol2qm74	2969	54	and	and	CC
cord-015021-pol2qm74	2969	55	albumin	albumin	NN
cord-015021-pol2qm74	2969	56	(	(	-LRB-
cord-015021-pol2qm74	2969	57	29.0	29.0	CD
cord-015021-pol2qm74	2969	58	+	+	SYM
cord-015021-pol2qm74	2969	59	1.5	1.5	CD
cord-015021-pol2qm74	2969	60	gms	gms	NN
cord-015021-pol2qm74	2969	61	/	/	SYM
cord-015021-pol2qm74	2969	62	L	l	NN
cord-015021-pol2qm74	2969	63	vs.	vs.	NN
cord-015021-pol2qm74	2969	64	26.0+_1.6	26.0+_1.6	CD
cord-015021-pol2qm74	2969	65	gms	gms	NNP
cord-015021-pol2qm74	2969	66	/	/	SYM
cord-015021-pol2qm74	2969	67	L	L	NNP
cord-015021-pol2qm74	2969	68	)	)	-RRB-
cord-015021-pol2qm74	2969	69	were	be	VBD
cord-015021-pol2qm74	2969	70	not	not	RB
cord-015021-pol2qm74	2969	71	different	different	JJ
cord-015021-pol2qm74	2969	72	between	between	IN
cord-015021-pol2qm74	2969	73	CNTF	CNTF	NNP
cord-015021-pol2qm74	2969	74	and	and	CC
cord-015021-pol2qm74	2969	75	freely	freely	RB
cord-015021-pol2qm74	2969	76	fed	feed	VBD
cord-015021-pol2qm74	2969	77	animals	animal	NNS
cord-015021-pol2qm74	2969	78	.	.	.
cord-015021-pol2qm74	2970	1	We	-PRON-	PRP
cord-015021-pol2qm74	2970	2	conclude	conclude	VBP
cord-015021-pol2qm74	2970	3	that	that	IN
cord-015021-pol2qm74	2970	4	CNTF	CNTF	NNP
cord-015021-pol2qm74	2970	5	causes	cause	VBZ
cord-015021-pol2qm74	2970	6	anorexia	anorexia	NN
cord-015021-pol2qm74	2970	7	,	,	,
cord-015021-pol2qm74	2970	8	and	and	CC
cord-015021-pol2qm74	2970	9	increases	increase	VBZ
cord-015021-pol2qm74	2970	10	body	body	NN
cord-015021-pol2qm74	2970	11	weight	weight	NN
cord-015021-pol2qm74	2970	12	loss	loss	NN
cord-015021-pol2qm74	2970	13	in	in	IN
cord-015021-pol2qm74	2970	14	excess	excess	NN
cord-015021-pol2qm74	2970	15	of	of	IN
cord-015021-pol2qm74	2970	16	the	the	DT
cord-015021-pol2qm74	2970	17	associated	associate	VBN
cord-015021-pol2qm74	2970	18	anorexia	anorexia	NN
cord-015021-pol2qm74	2970	19	.	.	.
cord-015021-pol2qm74	2971	1	Unlike	unlike	IN
cord-015021-pol2qm74	2971	2	the	the	DT
cord-015021-pol2qm74	2971	3	cachexia	cachexia	NN
cord-015021-pol2qm74	2971	4	associated	associate	VBN
cord-015021-pol2qm74	2971	5	with	with	IN
cord-015021-pol2qm74	2971	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	2971	7	and	and	CC
cord-015021-pol2qm74	2971	8	TNF	TNF	NNP
cord-015021-pol2qm74	2971	9	infusions	infusion	NNS
cord-015021-pol2qm74	2971	10	,	,	,
cord-015021-pol2qm74	2971	11	which	which	WDT
cord-015021-pol2qm74	2971	12	is	be	VBZ
cord-015021-pol2qm74	2971	13	associated	associate	VBN
cord-015021-pol2qm74	2971	14	with	with	IN
cord-015021-pol2qm74	2971	15	an	an	DT
cord-015021-pol2qm74	2971	16	acute	acute	JJ
cord-015021-pol2qm74	2971	17	phase	phase	NN
cord-015021-pol2qm74	2971	18	response	response	NN
cord-015021-pol2qm74	2971	19	,	,	,
cord-015021-pol2qm74	2971	20	CNTF	CNTF	NNP
cord-015021-pol2qm74	2971	21	acts	act	VBZ
cord-015021-pol2qm74	2971	22	predominantly	predominantly	RB
cord-015021-pol2qm74	2971	23	on	on	IN
cord-015021-pol2qm74	2971	24	food	food	NN
cord-015021-pol2qm74	2971	25	intake	intake	NN
cord-015021-pol2qm74	2971	26	and	and	CC
cord-015021-pol2qm74	2971	27	carcass	carcass	NN
cord-015021-pol2qm74	2971	28	weight	weight	NN
cord-015021-pol2qm74	2971	29	through	through	IN
cord-015021-pol2qm74	2971	30	a	a	DT
cord-015021-pol2qm74	2971	31	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	2971	32	-	-	HYPH
cord-015021-pol2qm74	2971	33	independent	independent	JJ
cord-015021-pol2qm74	2971	34	mechanism	mechanism	NN
cord-015021-pol2qm74	2971	35	and	and	CC
cord-015021-pol2qm74	2971	36	has	have	VBZ
cord-015021-pol2qm74	2971	37	only	only	RB
cord-015021-pol2qm74	2971	38	minimal	minimal	JJ
cord-015021-pol2qm74	2971	39	acute	acute	JJ
cord-015021-pol2qm74	2971	40	phase	phase	NN
cord-015021-pol2qm74	2971	41	inducing	induce	VBG
cord-015021-pol2qm74	2971	42	properties	property	NNS
cord-015021-pol2qm74	2971	43	,	,	,
cord-015021-pol2qm74	2971	44	N.	N.	NNP
cord-015021-pol2qm74	2971	45	Joseph	Joseph	NNP
cord-015021-pol2qm74	2971	46	Espat	Espat	NNP
cord-015021-pol2qm74	2971	47	,	,	,
cord-015021-pol2qm74	2971	48	MD	MD	NNP
cord-015021-pol2qm74	2971	49	.	.	.
cord-015021-pol2qm74	2972	1	University	University	NNP
cord-015021-pol2qm74	2972	2	of	of	IN
cord-015021-pol2qm74	2972	3	Florida	Florida	NNP
cord-015021-pol2qm74	2972	4	,	,	,
cord-015021-pol2qm74	2972	5	Department	Department	NNP
cord-015021-pol2qm74	2972	6	of	of	IN
cord-015021-pol2qm74	2972	7	Surgery	Surgery	NNP
cord-015021-pol2qm74	2972	8	,	,	,
cord-015021-pol2qm74	2972	9	J	J	NNP
cord-015021-pol2qm74	2972	10	-	-	HYPH
cord-015021-pol2qm74	2972	11	Box	Box	NNP
cord-015021-pol2qm74	2972	12	100286	100286	CD
cord-015021-pol2qm74	2972	13	,	,	,
cord-015021-pol2qm74	2972	14	Gainesville	Gainesville	NNP
cord-015021-pol2qm74	2972	15	,	,	,
cord-015021-pol2qm74	2972	16	FL	FL	NNP
cord-015021-pol2qm74	2972	17	.	.	.
cord-015021-pol2qm74	2973	1	32610	32610	CD
cord-015021-pol2qm74	2973	2	.	.	.
cord-015021-pol2qm74	2974	1	OF	of	IN
cord-015021-pol2qm74	2974	2	CYTOKINES	CYTOKINES	NNP
cord-015021-pol2qm74	2975	1	BY	by	IN
cord-015021-pol2qm74	2975	2	NEUROTROPHIC	NEUROTROPHIC	NNP
cord-015021-pol2qm74	2975	3	FACTORS	factors	NN
cord-015021-pol2qm74	2975	4	,	,	,
cord-015021-pol2qm74	2976	1	THE	the	DT
cord-015021-pol2qm74	2976	2	NEUROENDOCRINE	NEUROENDOCRINE	NNP
cord-015021-pol2qm74	2976	3	SYSTEM	system	NN
cord-015021-pol2qm74	2976	4	AND	and	CC
cord-015021-pol2qm74	2976	5	PHENOTIAZINES	PHENOTIAZINES	NNP
cord-015021-pol2qm74	2976	6	.	.	.
cord-015021-pol2qm74	2977	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	2977	2	,	,	,
cord-015021-pol2qm74	2977	3	including	include	VBG
cord-015021-pol2qm74	2977	4	TNF	TNF	NNP
cord-015021-pol2qm74	2977	5	and	and	CC
cord-015021-pol2qm74	2977	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	2977	7	,	,	,
cord-015021-pol2qm74	2977	8	have	have	VBP
cord-015021-pol2qm74	2977	9	a	a	DT
cord-015021-pol2qm74	2977	10	pathogenetic	pathogenetic	JJ
cord-015021-pol2qm74	2977	11	role	role	NN
cord-015021-pol2qm74	2977	12	in	in	IN
cord-015021-pol2qm74	2977	13	various	various	JJ
cord-015021-pol2qm74	2977	14	diseases	disease	NNS
cord-015021-pol2qm74	2977	15	related	relate	VBN
cord-015021-pol2qm74	2977	16	to	to	IN
cord-015021-pol2qm74	2977	17	infection	infection	NN
cord-015021-pol2qm74	2977	18	and	and	CC
cord-015021-pol2qm74	2977	19	inflammation	inflammation	NN
cord-015021-pol2qm74	2977	20	.	.	.
cord-015021-pol2qm74	2978	1	The	the	DT
cord-015021-pol2qm74	2978	2	action	action	NN
cord-015021-pol2qm74	2978	3	and/or	and/or	CC
cord-015021-pol2qm74	2978	4	production	production	NN
cord-015021-pol2qm74	2978	5	of	of	IN
cord-015021-pol2qm74	2978	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	2978	7	can	can	MD
cord-015021-pol2qm74	2978	8	be	be	VB
cord-015021-pol2qm74	2978	9	regulated	regulate	VBN
cord-015021-pol2qm74	2978	10	by	by	IN
cord-015021-pol2qm74	2978	11	drugs	drug	NNS
cord-015021-pol2qm74	2978	12	or	or	CC
cord-015021-pol2qm74	2978	13	endogenous	endogenous	JJ
cord-015021-pol2qm74	2978	14	mechanisms	mechanism	NNS
cord-015021-pol2qm74	2978	15	that	that	WDT
cord-015021-pol2qm74	2978	16	involve	involve	VBP
cord-015021-pol2qm74	2978	17	the	the	DT
cord-015021-pol2qm74	2978	18	cetral	cetral	JJ
cord-015021-pol2qm74	2978	19	nervous	nervous	JJ
cord-015021-pol2qm74	2978	20	system	system	NN
cord-015021-pol2qm74	2978	21	(	(	-LRB-
cord-015021-pol2qm74	2978	22	CNS	CNS	NNP
cord-015021-pol2qm74	2978	23	)	)	-RRB-
cord-015021-pol2qm74	2979	1	We	-PRON-	PRP
cord-015021-pol2qm74	2979	2	found	find	VBD
cord-015021-pol2qm74	2979	3	that	that	IN
cord-015021-pol2qm74	2979	4	the	the	DT
cord-015021-pol2qm74	2979	5	antipsychotic	antipsychotic	JJ
cord-015021-pol2qm74	2979	6	chlorpromazine	chlorpromazine	NN
cord-015021-pol2qm74	2979	7	(	(	-LRB-
cord-015021-pol2qm74	2979	8	CPZ	CPZ	NNP
cord-015021-pol2qm74	2979	9	)	)	-RRB-
cord-015021-pol2qm74	2979	10	potently	potently	RB
cord-015021-pol2qm74	2979	11	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2979	12	TNF	tnf	NN
cord-015021-pol2qm74	2979	13	production	production	NN
cord-015021-pol2qm74	2979	14	and	and	CC
cord-015021-pol2qm74	2979	15	protects	protect	VBZ
cord-015021-pol2qm74	2979	16	mice	mouse	NNS
cord-015021-pol2qm74	2979	17	against	against	IN
cord-015021-pol2qm74	2979	18	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	2979	19	shock	shock	NN
cord-015021-pol2qm74	2979	20	.	.	.
cord-015021-pol2qm74	2980	1	CPZ	CPZ	NNP
cord-015021-pol2qm74	2980	2	also	also	RB
cord-015021-pol2qm74	2980	3	inhibits	inhibit	VBZ
cord-015021-pol2qm74	2980	4	brain	brain	NN
cord-015021-pol2qm74	2980	5	TNF	TNF	NNP
cord-015021-pol2qm74	2980	6	production	production	NN
cord-015021-pol2qm74	2980	7	in	in	IN
cord-015021-pol2qm74	2980	8	mice	mice	NN
cord-015021-pol2qm74	2980	9	intracerebrally	intracerebrally	RB
cord-015021-pol2qm74	2980	10	injected	inject	VBN
cord-015021-pol2qm74	2980	11	with	with	IN
cord-015021-pol2qm74	2980	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2980	13	,	,	,
cord-015021-pol2qm74	2980	14	whereas	whereas	IN
cord-015021-pol2qm74	2980	15	CPZ	CPZ	NNP
cord-015021-pol2qm74	2980	16	analogs	analog	NNS
cord-015021-pol2qm74	2980	17	that	that	WDT
cord-015021-pol2qm74	2980	18	do	do	VBP
cord-015021-pol2qm74	2980	19	not	not	RB
cord-015021-pol2qm74	2980	20	cross	cross	VB
cord-015021-pol2qm74	2980	21	the	the	DT
cord-015021-pol2qm74	2980	22	blood	blood	NN
cord-015021-pol2qm74	2980	23	-	-	HYPH
cord-015021-pol2qm74	2980	24	brain	brain	NN
cord-015021-pol2qm74	2980	25	barrier	barrier	NN
cord-015021-pol2qm74	2980	26	inhibit	inhibit	VBP
cord-015021-pol2qm74	2980	27	only	only	RB
cord-015021-pol2qm74	2980	28	perypheral	perypheral	JJ
cord-015021-pol2qm74	2980	29	,	,	,
cord-015021-pol2qm74	2980	30	not	not	RB
cord-015021-pol2qm74	2980	31	brain	brain	NN
cord-015021-pol2qm74	2980	32	,	,	,
cord-015021-pol2qm74	2980	33	TNF	TNF	NNP
cord-015021-pol2qm74	2980	34	.	.	.
cord-015021-pol2qm74	2981	1	TNF	tnf	NN
cord-015021-pol2qm74	2981	2	production	production	NN
cord-015021-pol2qm74	2981	3	and	and	CC
cord-015021-pol2qm74	2981	4	susceptibility	susceptibility	NN
cord-015021-pol2qm74	2981	5	to	to	IN
cord-015021-pol2qm74	2981	6	the	the	DT
cord-015021-pol2qm74	2981	7	toxicity	toxicity	NN
cord-015021-pol2qm74	2981	8	of	of	IN
cord-015021-pol2qm74	2981	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2981	10	,	,	,
cord-015021-pol2qm74	2981	11	TNF	TNF	NNP
cord-015021-pol2qm74	2981	12	and	and	CC
cord-015021-pol2qm74	2981	13	IL-1	IL-1	NNP
cord-015021-pol2qm74	2981	14	are	be	VBP
cord-015021-pol2qm74	2981	15	increased	increase	VBN
cord-015021-pol2qm74	2981	16	in	in	IN
cord-015021-pol2qm74	2981	17	adrenalectomized	adrenalectomize	VBN
cord-015021-pol2qm74	2981	18	mice	mouse	NNS
cord-015021-pol2qm74	2981	19	,	,	,
cord-015021-pol2qm74	2981	20	indicating	indicate	VBG
cord-015021-pol2qm74	2981	21	that	that	IN
cord-015021-pol2qm74	2981	22	endogenous	endogenous	JJ
cord-015021-pol2qm74	2981	23	corticosterone	corticosterone	NN
cord-015021-pol2qm74	2981	24	(	(	-LRB-
cord-015021-pol2qm74	2981	25	CS	CS	NNP
cord-015021-pol2qm74	2981	26	)	)	-RRB-
cord-015021-pol2qm74	2981	27	controls	control	VBZ
cord-015021-pol2qm74	2981	28	cytokine	cytokine	NN
cord-015021-pol2qm74	2981	29	production	production	NN
cord-015021-pol2qm74	2981	30	and	and	CC
cord-015021-pol2qm74	2981	31	toxicity	toxicity	NN
cord-015021-pol2qm74	2981	32	,	,	,
cord-015021-pol2qm74	2981	33	in	in	IN
cord-015021-pol2qm74	2981	34	a	a	DT
cord-015021-pol2qm74	2981	35	feedback	feedback	NN
cord-015021-pol2qm74	2981	36	fashion	fashion	NN
cord-015021-pol2qm74	2981	37	since	since	IN
cord-015021-pol2qm74	2981	38	endotoxin	endotoxin	NN
cord-015021-pol2qm74	2981	39	and	and	CC
cord-015021-pol2qm74	2981	40	cytokines	cytokine	NNS
cord-015021-pol2qm74	2981	41	increase	increase	VBP
cord-015021-pol2qm74	2981	42	serum	serum	NN
cord-015021-pol2qm74	2981	43	CS	cs	NN
cord-015021-pol2qm74	2981	44	.	.	.
cord-015021-pol2qm74	2982	1	Increased	increase	VBN
cord-015021-pol2qm74	2982	2	TNF	TNF	NNP
cord-015021-pol2qm74	2982	3	production	production	NN
cord-015021-pol2qm74	2982	4	was	be	VBD
cord-015021-pol2qm74	2982	5	also	also	RB
cord-015021-pol2qm74	2982	6	observed	observe	VBN
cord-015021-pol2qm74	2982	7	in	in	IN
cord-015021-pol2qm74	2982	8	mice	mouse	NNS
cord-015021-pol2qm74	2982	9	where	where	WRB
cord-015021-pol2qm74	2982	10	the	the	DT
cord-015021-pol2qm74	2982	11	hypothalamus	hypothalamus	NN
cord-015021-pol2qm74	2982	12	-	-	HYPH
cord-015021-pol2qm74	2982	13	pituitary	pituitary	NN
cord-015021-pol2qm74	2982	14	-	-	HYPH
cord-015021-pol2qm74	2982	15	adrenal	adrenal	NN
cord-015021-pol2qm74	2982	16	axis	axis	NN
cord-015021-pol2qm74	2982	17	was	be	VBD
cord-015021-pol2qm74	2982	18	blocked	block	VBN
cord-015021-pol2qm74	2982	19	by	by	IN
cord-015021-pol2qm74	2982	20	chronic	chronic	JJ
cord-015021-pol2qm74	2982	21	administration	administration	NN
cord-015021-pol2qm74	2982	22	of	of	IN
cord-015021-pol2qm74	2982	23	dexamethasone	dexamethasone	NNP
cord-015021-pol2qm74	2982	24	,	,	,
cord-015021-pol2qm74	2982	25	following	follow	VBG
cord-015021-pol2qm74	2982	26	a	a	DT
cord-015021-pol2qm74	2982	27	two	two	CD
cord-015021-pol2qm74	2982	28	-	-	HYPH
cord-015021-pol2qm74	2982	29	day	day	NN
cord-015021-pol2qm74	2982	30	washout	washout	NN
cord-015021-pol2qm74	2982	31	.	.	.
cord-015021-pol2qm74	2983	1	Administration	administration	NN
cord-015021-pol2qm74	2983	2	of	of	IN
cord-015021-pol2qm74	2983	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	2983	4	acting	act	VBG
cord-015021-pol2qm74	2983	5	through	through	IN
cord-015021-pol2qm74	2983	6	the	the	DT
cord-015021-pol2qm74	2983	7	gp130	gp130	NNP
cord-015021-pol2qm74	2983	8	signal	signal	NN
cord-015021-pol2qm74	2983	9	transd	transd	NN
cord-015021-pol2qm74	2983	10	,	,	,
cord-015021-pol2qm74	2983	11	uction	uction	NNP
cord-015021-pol2qm74	2983	12	protein	protein	NN
cord-015021-pol2qm74	2983	13	,	,	,
cord-015021-pol2qm74	2983	14	including	include	VBG
cord-015021-pol2qm74	2983	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	2983	16	and	and	CC
cord-015021-pol2qm74	2983	17	ciliary	ciliary	NN
cord-015021-pol2qm74	2983	18	neurotrophic	neurotrophic	NN
cord-015021-pol2qm74	2983	19	factor	factor	NN
cord-015021-pol2qm74	2983	20	,	,	,
cord-015021-pol2qm74	2983	21	CNTF	CNTF	NNP
cord-015021-pol2qm74	2983	22	potentiated	potentiate	VBD
cord-015021-pol2qm74	2983	23	IL	IL	NNP
cord-015021-pol2qm74	2983	24	-	-	HYPH
cord-015021-pol2qm74	2983	25	l	l	NN
cord-015021-pol2qm74	2983	26	-	-	HYPH
cord-015021-pol2qm74	2983	27	induced	induce	VBN
cord-015021-pol2qm74	2983	28	elevation	elevation	NN
cord-015021-pol2qm74	2983	29	of	of	IN
cord-015021-pol2qm74	2983	30	CS	CS	NNP
cord-015021-pol2qm74	2983	31	.	.	.
cord-015021-pol2qm74	2984	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	2984	2	and	and	CC
cord-015021-pol2qm74	2984	3	CNTF	CNTF	NNP
cord-015021-pol2qm74	2984	4	also	also	RB
cord-015021-pol2qm74	2984	5	induced	induce	VBD
cord-015021-pol2qm74	2984	6	hepatic	hepatic	JJ
cord-015021-pol2qm74	2984	7	acute	acute	JJ
cord-015021-pol2qm74	2984	8	-	-	HYPH
cord-015021-pol2qm74	2984	9	phase	phase	NN
cord-015021-pol2qm74	2984	10	proteins	protein	NNS
cord-015021-pol2qm74	2984	11	.	.	.
cord-015021-pol2qm74	2985	1	Thus	thus	RB
cord-015021-pol2qm74	2985	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	2985	3	and	and	CC
cord-015021-pol2qm74	2985	4	CNTF	CNTF	NNP
cord-015021-pol2qm74	2985	5	might	may	MD
cord-015021-pol2qm74	2985	6	have	have	VB
cord-015021-pol2qm74	2985	7	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	2985	8	activity	activity	NN
cord-015021-pol2qm74	2985	9	,	,	,
cord-015021-pol2qm74	2985	10	by	by	IN
cord-015021-pol2qm74	2985	11	potentiating	potentiate	VBG
cord-015021-pol2qm74	2985	12	the	the	DT
cord-015021-pol2qm74	2985	13	feedback	feedback	NN
cord-015021-pol2qm74	2985	14	responses	response	NNS
cord-015021-pol2qm74	2985	15	of	of	IN
cord-015021-pol2qm74	2985	16	the	the	DT
cord-015021-pol2qm74	2985	17	neuroendocrine	neuroendocrine	JJ
cord-015021-pol2qm74	2985	18	axis	axis	NN
cord-015021-pol2qm74	2985	19	.	.	.
cord-015021-pol2qm74	2986	1	These	these	DT
cord-015021-pol2qm74	2986	2	data	datum	NNS
cord-015021-pol2qm74	2986	3	indicate	indicate	VBP
cord-015021-pol2qm74	2986	4	how	how	WRB
cord-015021-pol2qm74	2986	5	complex	complex	JJ
cord-015021-pol2qm74	2986	6	can	can	MD
cord-015021-pol2qm74	2986	7	be	be	VB
cord-015021-pol2qm74	2986	8	the	the	DT
cord-015021-pol2qm74	2986	9	interregulatory	interregulatory	JJ
cord-015021-pol2qm74	2986	10	relationships	relationship	NNS
cord-015021-pol2qm74	2986	11	between	between	IN
cord-015021-pol2qm74	2986	12	the	the	DT
cord-015021-pol2qm74	2986	13	brain	brain	NN
cord-015021-pol2qm74	2986	14	and	and	CC
cord-015021-pol2qm74	2986	15	the	the	DT
cord-015021-pol2qm74	2986	16	immune	immune	JJ
cord-015021-pol2qm74	2986	17	system	system	NN
cord-015021-pol2qm74	2986	18	,	,	,
cord-015021-pol2qm74	2986	19	how	how	WRB
cord-015021-pol2qm74	2986	20	they	-PRON-	PRP
cord-015021-pol2qm74	2986	21	can	can	MD
cord-015021-pol2qm74	2986	22	be	be	VB
cord-015021-pol2qm74	2986	23	used	use	VBN
cord-015021-pol2qm74	2986	24	to	to	IN
cord-015021-pol2qm74	2986	25	pharmacomodulate	pharmacomodulate	NNP
cord-015021-pol2qm74	2986	26	cytokine	cytokine	JJ
cord-015021-pol2qm74	2986	27	action	action	NN
cord-015021-pol2qm74	2986	28	and	and	CC
cord-015021-pol2qm74	2986	29	how	how	WRB
cord-015021-pol2qm74	2986	30	their	-PRON-	PRP$
cord-015021-pol2qm74	2986	31	disregulation	disregulation	NN
cord-015021-pol2qm74	2986	32	might	may	MD
cord-015021-pol2qm74	2986	33	exacerbate	exacerbate	VB
cord-015021-pol2qm74	2986	34	IL-1-and	IL-1-and	NNP
cord-015021-pol2qm74	2986	35	TNF	TNF	NNP
cord-015021-pol2qm74	2986	36	-	-	HYPH
cord-015021-pol2qm74	2986	37	mediated	mediate	VBN
cord-015021-pol2qm74	2986	38	pathologies	pathology	NNS
cord-015021-pol2qm74	2986	39	.	.	.
cord-015021-pol2qm74	2987	1	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-015021-pol2qm74	2987	2	(	(	-LRB-
cord-015021-pol2qm74	2987	3	LPS	LPS	NNP
cord-015021-pol2qm74	2987	4	)	)	-RRB-
cord-015021-pol2qm74	2987	5	constitutes	constitute	VBZ
cord-015021-pol2qm74	2987	6	a	a	DT
cord-015021-pol2qm74	2987	7	well	well	RB
cord-015021-pol2qm74	2987	8	established	establish	VBN
cord-015021-pol2qm74	2987	9	activator	activator	NN
cord-015021-pol2qm74	2987	10	of	of	IN
cord-015021-pol2qm74	2987	11	monocytes/	monocytes/	CD
cord-015021-pol2qm74	2987	12	macrophages	macrophage	NNS
cord-015021-pol2qm74	2987	13	(	(	-LRB-
cord-015021-pol2qm74	2987	14	MIZI	MIZI	NNP
cord-015021-pol2qm74	2987	15	)	)	-RRB-
cord-015021-pol2qm74	2987	16	and	and	CC
cord-015021-pol2qm74	2987	17	murine	murine	JJ
cord-015021-pol2qm74	2987	18	B	b	NN
cord-015021-pol2qm74	2987	19	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	2987	20	.	.	.
cord-015021-pol2qm74	2988	1	The	the	DT
cord-015021-pol2qm74	2988	2	hydrophobic	hydrophobic	JJ
cord-015021-pol2qm74	2988	3	part	part	NN
cord-015021-pol2qm74	2988	4	of	of	IN
cord-015021-pol2qm74	2988	5	LPS	LPS	NNP
cord-015021-pol2qm74	2988	6	,	,	,
cord-015021-pol2qm74	2988	7	termed	term	VBD
cord-015021-pol2qm74	2988	8	lipid	lipid	NN
cord-015021-pol2qm74	2988	9	A	a	NN
cord-015021-pol2qm74	2988	10	,	,	,
cord-015021-pol2qm74	2988	11	represents	represent	VBZ
cord-015021-pol2qm74	2988	12	the	the	DT
cord-015021-pol2qm74	2988	13	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	2988	14	principle	principle	NN
cord-015021-pol2qm74	2988	15	of	of	IN
cord-015021-pol2qm74	2988	16	LPS	LPS	NNP
cord-015021-pol2qm74	2988	17	.	.	.
cord-015021-pol2qm74	2989	1	We	-PRON-	PRP
cord-015021-pol2qm74	2989	2	now	now	RB
cord-015021-pol2qm74	2989	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	2989	4	that	that	IN
cord-015021-pol2qm74	2989	5	LPS	LPS	NNP
cord-015021-pol2qm74	2989	6	is	be	VBZ
cord-015021-pol2qm74	2989	7	also	also	RB
cord-015021-pol2qm74	2989	8	capable	capable	JJ
cord-015021-pol2qm74	2989	9	of	of	IN
cord-015021-pol2qm74	2989	10	inducing	induce	VBG
cord-015021-pol2qm74	2989	11	proliferation	proliferation	NN
cord-015021-pol2qm74	2989	12	of	of	IN
cord-015021-pol2qm74	2989	13	human	human	JJ
cord-015021-pol2qm74	2989	14	T	t	NN
cord-015021-pol2qm74	2989	15	cells	cell	NNS
cord-015021-pol2qm74	2989	16	at	at	IN
cord-015021-pol2qm74	2989	17	a	a	DT
cord-015021-pol2qm74	2989	18	dose	dose	NN
cord-015021-pol2qm74	2989	19	of	of	IN
cord-015021-pol2qm74	2989	20	10	10	CD
cord-015021-pol2qm74	2989	21	to	to	TO
cord-015021-pol2qm74	2989	22	1000	1000	CD
cord-015021-pol2qm74	2989	23	pg	pg	NN
cord-015021-pol2qm74	2989	24	/	/	SYM
cord-015021-pol2qm74	2989	25	ml	ml	NN
cord-015021-pol2qm74	2989	26	.	.	.
cord-015021-pol2qm74	2990	1	The	the	DT
cord-015021-pol2qm74	2990	2	specificity	specificity	NN
cord-015021-pol2qm74	2990	3	of	of	IN
cord-015021-pol2qm74	2990	4	this	this	DT
cord-015021-pol2qm74	2990	5	stimulation	stimulation	NN
cord-015021-pol2qm74	2990	6	was	be	VBD
cord-015021-pol2qm74	2990	7	analysed	analyse	VBN
cord-015021-pol2qm74	2990	8	by	by	IN
cord-015021-pol2qm74	2990	9	the	the	DT
cord-015021-pol2qm74	2990	10	following	follow	VBG
cord-015021-pol2qm74	2990	11	experiments	experiment	NNS
cord-015021-pol2qm74	2990	12	:	:	:
cord-015021-pol2qm74	2990	13	i	i	NN
cord-015021-pol2qm74	2990	14	)	)	-RRB-
cord-015021-pol2qm74	2991	1	The	the	DT
cord-015021-pol2qm74	2991	2	synthetic	synthetic	JJ
cord-015021-pol2qm74	2991	3	hexaacyl	hexaacyl	NNP
cord-015021-pol2qm74	2991	4	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	2991	5	coiltype	coiltype	NN
cord-015021-pol2qm74	2991	6	lipid	lipid	NN
cord-015021-pol2qm74	2991	7	A	a	DT
cord-015021-pol2qm74	2991	8	(	(	-LRB-
cord-015021-pol2qm74	2991	9	compound	compound	NN
cord-015021-pol2qm74	2991	10	506	506	CD
cord-015021-pol2qm74	2991	11	)	)	-RRB-
cord-015021-pol2qm74	2991	12	also	also	RB
cord-015021-pol2qm74	2991	13	stimulated	stimulate	VBD
cord-015021-pol2qm74	2991	14	human	human	JJ
cord-015021-pol2qm74	2991	15	T	t	NN
cord-015021-pol2qm74	2991	16	cells	cell	NNS
cord-015021-pol2qm74	2991	17	;	;	:
cord-015021-pol2qm74	2991	18	ii	ii	LS
cord-015021-pol2qm74	2991	19	)	)	-RRB-
cord-015021-pol2qm74	2991	20	the	the	DT
cord-015021-pol2qm74	2991	21	synthetic	synthetic	JJ
cord-015021-pol2qm74	2991	22	tetraacyl	tetraacyl	NNP
cord-015021-pol2qm74	2991	23	lipid	lipid	NN
cord-015021-pol2qm74	2991	24	A	a	DT
cord-015021-pol2qm74	2991	25	precursor	precursor	NN
cord-015021-pol2qm74	2991	26	(	(	-LRB-
cord-015021-pol2qm74	2991	27	compound	compound	NN
cord-015021-pol2qm74	2991	28	406	406	CD
cord-015021-pol2qm74	2991	29	)	)	-RRB-
cord-015021-pol2qm74	2991	30	or	or	CC
cord-015021-pol2qm74	2991	31	the	the	DT
cord-015021-pol2qm74	2991	32	1phosphono	1phosphono	CD
cord-015021-pol2qm74	2991	33	-	-	HYPH
cord-015021-pol2qm74	2991	34	oxyethyl	oxyethyl	NN
cord-015021-pol2qm74	2991	35	analogue	analogue	NN
cord-015021-pol2qm74	2991	36	PE-4	PE-4	NNP
cord-015021-pol2qm74	2991	37	,	,	,
cord-015021-pol2qm74	2991	38	structures	structure	NNS
cord-015021-pol2qm74	2991	39	known	know	VBN
cord-015021-pol2qm74	2991	40	to	to	TO
cord-015021-pol2qm74	2991	41	antagonize	antagonize	VB
cord-015021-pol2qm74	2991	42	LPS	LPS	NNP
cord-015021-pol2qm74	2991	43	-	-	HYPH
cord-015021-pol2qm74	2991	44	induced	induce	VBN
cord-015021-pol2qm74	2991	45	monokine	monokine	NN
cord-015021-pol2qm74	2991	46	production	production	NN
cord-015021-pol2qm74	2991	47	in	in	IN
cord-015021-pol2qm74	2991	48	human	human	JJ
cord-015021-pol2qm74	2991	49	MZ	MZ	NNP
cord-015021-pol2qm74	2991	50	,	,	,
cord-015021-pol2qm74	2991	51	also	also	RB
cord-015021-pol2qm74	2991	52	inhibited	inhibit	VBD
cord-015021-pol2qm74	2991	53	LPSinduced	LPSinduced	NNP
cord-015021-pol2qm74	2991	54	T	t	NN
cord-015021-pol2qm74	2991	55	-	-	HYPH
cord-015021-pol2qm74	2991	56	cell	cell	NN
cord-015021-pol2qm74	2991	57	proliferation	proliferation	NN
cord-015021-pol2qm74	2991	58	.	.	.
cord-015021-pol2qm74	2992	1	The	the	DT
cord-015021-pol2qm74	2992	2	T	t	NN
cord-015021-pol2qm74	2992	3	-	-	HYPH
cord-015021-pol2qm74	2992	4	cell	cell	NN
cord-015021-pol2qm74	2992	5	proliferation	proliferation	NN
cord-015021-pol2qm74	2992	6	expressed	express	VBD
cord-015021-pol2qm74	2992	7	the	the	DT
cord-015021-pol2qm74	2992	8	following	follow	VBG
cord-015021-pol2qm74	2992	9	features	feature	NNS
cord-015021-pol2qm74	2992	10	:	:	:
cord-015021-pol2qm74	2992	11	i	i	LS
cord-015021-pol2qm74	2992	12	)	)	-RRB-
cord-015021-pol2qm74	2992	13	CD4	CD4	NNP
cord-015021-pol2qm74	2992	14	÷-as	÷-as	POS
cord-015021-pol2qm74	2992	15	welt	welt	NN
cord-015021-pol2qm74	2992	16	as	as	IN
cord-015021-pol2qm74	2992	17	CD8	CD8	NNP
cord-015021-pol2qm74	2992	18	÷	÷	NNP
cord-015021-pol2qm74	2992	19	T	T	NNP
cord-015021-pol2qm74	2992	20	cells	cell	NNS
cord-015021-pol2qm74	2992	21	proliferate	proliferate	VBP
cord-015021-pol2qm74	2992	22	in	in	IN
cord-015021-pol2qm74	2992	23	response	response	NN
cord-015021-pol2qm74	2992	24	to	to	IN
cord-015021-pol2qm74	2992	25	LPS	LPS	NNP
cord-015021-pol2qm74	2992	26	,	,	,
cord-015021-pol2qm74	2992	27	ii	ii	NN
cord-015021-pol2qm74	2992	28	)	)	-RRB-
cord-015021-pol2qm74	2992	29	limiting	limit	VBG
cord-015021-pol2qm74	2992	30	dilution	dilution	NN
cord-015021-pol2qm74	2992	31	analyses	analysis	NNS
cord-015021-pol2qm74	2992	32	reveal	reveal	VBP
cord-015021-pol2qm74	2992	33	that	that	IN
cord-015021-pol2qm74	2992	34	the	the	DT
cord-015021-pol2qm74	2992	35	frequency	frequency	NN
cord-015021-pol2qm74	2992	36	of	of	IN
cord-015021-pol2qm74	2992	37	responding	respond	VBG
cord-015021-pol2qm74	2992	38	cells	cell	NNS
cord-015021-pol2qm74	2992	39	was	be	VBD
cord-015021-pol2qm74	2992	40	between	between	IN
cord-015021-pol2qm74	2992	41	1/500	1/500	CD
cord-015021-pol2qm74	2992	42	to	to	TO
cord-015021-pol2qm74	2992	43	1/1000	1/1000	CD
cord-015021-pol2qm74	2992	44	cells	cell	NNS
cord-015021-pol2qm74	2992	45	;	;	:
cord-015021-pol2qm74	2992	46	iii	iii	LS
cord-015021-pol2qm74	2992	47	)	)	-RRB-
cord-015021-pol2qm74	2992	48	purified	purify	VBN
cord-015021-pol2qm74	2992	49	T	t	NN
cord-015021-pol2qm74	2992	50	cells	cell	NNS
cord-015021-pol2qm74	2992	51	alone	alone	RB
cord-015021-pol2qm74	2992	52	can	can	MD
cord-015021-pol2qm74	2992	53	not	not	RB
cord-015021-pol2qm74	2992	54	be	be	VB
cord-015021-pol2qm74	2992	55	stimulated	stimulate	VBN
cord-015021-pol2qm74	2992	56	by	by	IN
cord-015021-pol2qm74	2992	57	LPS	LPS	NNP
cord-015021-pol2qm74	2992	58	,	,	,
cord-015021-pol2qm74	2992	59	but	but	CC
cord-015021-pol2qm74	2992	60	need	need	VBP
cord-015021-pol2qm74	2992	61	the	the	DT
cord-015021-pol2qm74	2992	62	help	help	NN
cord-015021-pol2qm74	2992	63	of	of	IN
cord-015021-pol2qm74	2992	64	monocytes	monocyte	NNS
cord-015021-pol2qm74	2992	65	.	.	.
cord-015021-pol2qm74	2993	1	This	this	DT
cord-015021-pol2qm74	2993	2	help	help	NN
cord-015021-pol2qm74	2993	3	can	can	MD
cord-015021-pol2qm74	2993	4	not	not	RB
cord-015021-pol2qm74	2993	5	be	be	VB
cord-015021-pol2qm74	2993	6	replaced	replace	VBN
cord-015021-pol2qm74	2993	7	by	by	IN
cord-015021-pol2qm74	2993	8	B	b	NN
cord-015021-pol2qm74	2993	9	cells	cell	NNS
cord-015021-pol2qm74	2993	10	or	or	CC
cord-015021-pol2qm74	2993	11	fixed	fix	VBN
cord-015021-pol2qm74	2993	12	monocytes	monocyte	NNS
cord-015021-pol2qm74	2993	13	.	.	.
cord-015021-pol2qm74	2994	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	2994	2	,	,	,
cord-015021-pol2qm74	2994	3	for	for	IN
cord-015021-pol2qm74	2994	4	activation	activation	NN
cord-015021-pol2qm74	2994	5	a	a	DT
cord-015021-pol2qm74	2994	6	direct	direct	JJ
cord-015021-pol2qm74	2994	7	cell	cell	NN
cord-015021-pol2qm74	2994	8	-	-	HYPH
cord-015021-pol2qm74	2994	9	to	to	IN
cord-015021-pol2qm74	2994	10	-	-	HYPH
cord-015021-pol2qm74	2994	11	cell	cell	NN
cord-015021-pol2qm74	2994	12	contact	contact	NN
cord-015021-pol2qm74	2994	13	between	between	IN
cord-015021-pol2qm74	2994	14	T	t	NN
cord-015021-pol2qm74	2994	15	cells	cell	NNS
cord-015021-pol2qm74	2994	16	and	and	CC
cord-015021-pol2qm74	2994	17	monocyte	monocyte	NNP
cord-015021-pol2qm74	2994	18	is	be	VBZ
cord-015021-pol2qm74	2994	19	neccessary	neccessary	JJ
cord-015021-pol2qm74	2994	20	;	;	:
cord-015021-pol2qm74	2994	21	iv	iv	LS
cord-015021-pol2qm74	2994	22	)	)	-RRB-
cord-015021-pol2qm74	2994	23	T	t	NN
cord-015021-pol2qm74	2994	24	cells	cell	NNS
cord-015021-pol2qm74	2994	25	stimulated	stimulate	VBN
cord-015021-pol2qm74	2994	26	with	with	IN
cord-015021-pol2qm74	2994	27	LPS	LPS	NNP
cord-015021-pol2qm74	2994	28	express	express	VBP
cord-015021-pol2qm74	2994	29	mRNA	mrna	NN
cord-015021-pol2qm74	2994	30	for	for	IN
cord-015021-pol2qm74	2994	31	IL-2	IL-2	NNP
cord-015021-pol2qm74	2994	32	and	and	CC
cord-015021-pol2qm74	2994	33	IFNF	IFNF	NNP
cord-015021-pol2qm74	2994	34	,	,	,
cord-015021-pol2qm74	2994	35	but	but	CC
cord-015021-pol2qm74	2994	36	not	not	RB
cord-015021-pol2qm74	2994	37	for	for	IN
cord-015021-pol2qm74	2994	38	IL-4	IL-4	NNP
cord-015021-pol2qm74	2994	39	or	or	CC
cord-015021-pol2qm74	2994	40	IL-5	IL-5	NNP
cord-015021-pol2qm74	2994	41	(	(	-LRB-
cord-015021-pol2qm74	2994	42	determined	determine	VBN
cord-015021-pol2qm74	2994	43	by	by	IN
cord-015021-pol2qm74	2994	44	PCR	PCR	NNP
cord-015021-pol2qm74	2994	45	)	)	-RRB-
cord-015021-pol2qm74	2994	46	.	.	.
cord-015021-pol2qm74	2995	1	In	in	IN
cord-015021-pol2qm74	2995	2	supernatants	supernatant	NNS
cord-015021-pol2qm74	2995	3	,	,	,
cord-015021-pol2qm74	2995	4	IFNF	IFNF	NNP
cord-015021-pol2qm74	2995	5	was	be	VBD
cord-015021-pol2qm74	2995	6	detectable	detectable	JJ
cord-015021-pol2qm74	2995	7	(	(	-LRB-
cord-015021-pol2qm74	2995	8	ELISA	ELISA	NNP
cord-015021-pol2qm74	2995	9	)	)	-RRB-
cord-015021-pol2qm74	2995	10	;	;	:
cord-015021-pol2qm74	2995	11	v	v	LS
cord-015021-pol2qm74	2995	12	)	)	-RRB-
cord-015021-pol2qm74	2995	13	LPS	LPS	NNP
cord-015021-pol2qm74	2995	14	-	-	HYPH
cord-015021-pol2qm74	2995	15	activated	activate	VBN
cord-015021-pol2qm74	2995	16	CD4	CD4	NNP
cord-015021-pol2qm74	2995	17	÷	÷	NNP
cord-015021-pol2qm74	2995	18	as	as	RB
cord-015021-pol2qm74	2995	19	well	well	RB
cord-015021-pol2qm74	2995	20	as	as	IN
cord-015021-pol2qm74	2995	21	CD8	CD8	NNP
cord-015021-pol2qm74	2995	22	+	+	CC
cord-015021-pol2qm74	2995	23	T	T	NNP
cord-015021-pol2qm74	2995	24	cells	cell	NNS
cord-015021-pol2qm74	2995	25	express	express	VBP
cord-015021-pol2qm74	2995	26	CD25	CD25	NNP
cord-015021-pol2qm74	2995	27	,	,	,
cord-015021-pol2qm74	2995	28	the	the	DT
cord-015021-pol2qm74	2995	29	high	high	JJ
cord-015021-pol2qm74	2995	30	affinity	affinity	NN
cord-015021-pol2qm74	2995	31	IL-2	il-2	NN
cord-015021-pol2qm74	2995	32	receptor	receptor	NN
cord-015021-pol2qm74	2995	33	.	.	.
cord-015021-pol2qm74	2996	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	2996	2	results	result	NNS
cord-015021-pol2qm74	2996	3	indicate	indicate	VBP
cord-015021-pol2qm74	2996	4	that	that	IN
cord-015021-pol2qm74	2996	5	in	in	IN
cord-015021-pol2qm74	2996	6	contrast	contrast	NN
cord-015021-pol2qm74	2996	7	to	to	IN
cord-015021-pol2qm74	2996	8	previous	previous	JJ
cord-015021-pol2qm74	2996	9	reports	report	NNS
cord-015021-pol2qm74	2996	10	human	human	JJ
cord-015021-pol2qm74	2996	11	T	T	NNP
cord-015021-pol2qm74	2996	12	cells	cell	NNS
cord-015021-pol2qm74	2996	13	respond	respond	VBP
cord-015021-pol2qm74	2996	14	to	to	IN
cord-015021-pol2qm74	2996	15	LPS	LPS	NNP
cord-015021-pol2qm74	2996	16	with	with	IN
cord-015021-pol2qm74	2996	17	IL-2	IL-2	NNP
cord-015021-pol2qm74	2996	18	receptor	receptor	NN
cord-015021-pol2qm74	2996	19	expression	expression	NN
cord-015021-pol2qm74	2996	20	,	,	,
cord-015021-pol2qm74	2996	21	lymphokine	lymphokine	NN
cord-015021-pol2qm74	2996	22	production	production	NN
cord-015021-pol2qm74	2996	23	,	,	,
cord-015021-pol2qm74	2996	24	and	and	CC
cord-015021-pol2qm74	2996	25	proliferation	proliferation	NN
cord-015021-pol2qm74	2996	26	.	.	.
cord-015021-pol2qm74	2997	1	The	the	DT
cord-015021-pol2qm74	2997	2	reactive	reactive	JJ
cord-015021-pol2qm74	2997	3	cells	cell	NNS
cord-015021-pol2qm74	2997	4	appear	appear	VBP
cord-015021-pol2qm74	2997	5	to	to	TO
cord-015021-pol2qm74	2997	6	belong	belong	VB
cord-015021-pol2qm74	2997	7	to	to	IN
cord-015021-pol2qm74	2997	8	the	the	DT
cord-015021-pol2qm74	2997	9	T,1	t,1	CD
cord-015021-pol2qm74	2997	10	cell	cell	NN
cord-015021-pol2qm74	2997	11	type	type	NN
cord-015021-pol2qm74	2997	12	,	,	,
cord-015021-pol2qm74	2997	13	The	the	DT
cord-015021-pol2qm74	2997	14	finding	finding	NN
cord-015021-pol2qm74	2997	15	that	that	IN
cord-015021-pol2qm74	2997	16	human	human	JJ
cord-015021-pol2qm74	2997	17	T	t	NN
cord-015021-pol2qm74	2997	18	cells	cell	NNS
cord-015021-pol2qm74	2997	19	can	can	MD
cord-015021-pol2qm74	2997	20	be	be	VB
cord-015021-pol2qm74	2997	21	activated	activate	VBN
cord-015021-pol2qm74	2997	22	by	by	IN
cord-015021-pol2qm74	2997	23	LPS	LPS	NNP
cord-015021-pol2qm74	2997	24	is	be	VBZ
cord-015021-pol2qm74	2997	25	of	of	IN
cord-015021-pol2qm74	2997	26	important	important	JJ
cord-015021-pol2qm74	2997	27	relevance	relevance	NN
cord-015021-pol2qm74	2997	28	for	for	IN
cord-015021-pol2qm74	2997	29	the	the	DT
cord-015021-pol2qm74	2997	30	understanding	understanding	NN
cord-015021-pol2qm74	2997	31	of	of	IN
cord-015021-pol2qm74	2997	32	the	the	DT
cord-015021-pol2qm74	2997	33	pathomechanisms	pathomechanism	NNS
cord-015021-pol2qm74	2997	34	of	of	IN
cord-015021-pol2qm74	2997	35	infections	infection	NNS
cord-015021-pol2qm74	2997	36	by	by	IN
cord-015021-pol2qm74	2997	37	Gramnegative	Gramnegative	NNP
cord-015021-pol2qm74	2997	38	bacteria	bacteria	NNS
cord-015021-pol2qm74	2997	39	.	.	.
cord-015021-pol2qm74	2998	1	This	this	DT
cord-015021-pol2qm74	2998	2	may	may	MD
cord-015021-pol2qm74	2998	3	lead	lead	VB
cord-015021-pol2qm74	2998	4	to	to	IN
cord-015021-pol2qm74	2998	5	new	new	JJ
cord-015021-pol2qm74	2998	6	strategies	strategy	NNS
cord-015021-pol2qm74	2998	7	for	for	IN
cord-015021-pol2qm74	2998	8	the	the	DT
cord-015021-pol2qm74	2998	9	therapy	therapy	NN
cord-015021-pol2qm74	2998	10	of	of	IN
cord-015021-pol2qm74	2998	11	sepsis	sepsis	NN
cord-015021-pol2qm74	2998	12	.	.	.
cord-015021-pol2qm74	2999	1	We	-PRON-	PRP
cord-015021-pol2qm74	2999	2	have	have	VBP
cord-015021-pol2qm74	2999	3	recently	recently	RB
cord-015021-pol2qm74	2999	4	shown	show	VBN
cord-015021-pol2qm74	2999	5	that	that	IN
cord-015021-pol2qm74	2999	6	human	human	JJ
cord-015021-pol2qm74	2999	7	eosinophils	eosinophil	NNS
cord-015021-pol2qm74	2999	8	produce	produce	VBP
cord-015021-pol2qm74	2999	9	mRNA	mrna	NN
cord-015021-pol2qm74	2999	10	for	for	IN
cord-015021-pol2qm74	2999	11	interleukin	interleukin	NN
cord-015021-pol2qm74	2999	12	(	(	-LRB-
cord-015021-pol2qm74	2999	13	IL)-8	il)-8	RB
cord-015021-pol2qm74	2999	14	when	when	WRB
cord-015021-pol2qm74	2999	15	stimulated	stimulate	VBN
cord-015021-pol2qm74	2999	16	with	with	IN
cord-015021-pol2qm74	2999	17	calcium	calcium	NN
cord-015021-pol2qm74	2999	18	ionophore	ionophore	NNP
cord-015021-pol2qm74	2999	19	(	(	-LRB-
cord-015021-pol2qm74	2999	20	Eur	Eur	NNP
cord-015021-pol2qm74	2999	21	.	.	.
cord-015021-pol2qm74	2999	22	J.	J.	NNP
cord-015021-pol2qm74	2999	23	Immunol	Immunol	NNP
cord-015021-pol2qm74	2999	24	.	.	.
cord-015021-pol2qm74	3000	1	23	23	CD
cord-015021-pol2qm74	3000	2	(	(	-LRB-
cord-015021-pol2qm74	3000	3	1993	1993	CD
cord-015021-pol2qm74	3000	4	)	)	-RRB-
cord-015021-pol2qm74	3000	5	,	,	,
cord-015021-pol2qm74	3000	6	956	956	CD
cord-015021-pol2qm74	3000	7	)	)	-RRB-
cord-015021-pol2qm74	3000	8	.	.	.
cord-015021-pol2qm74	3001	1	We	-PRON-	PRP
cord-015021-pol2qm74	3001	2	now	now	RB
cord-015021-pol2qm74	3001	3	present	present	VBP
cord-015021-pol2qm74	3001	4	evidence	evidence	NN
cord-015021-pol2qm74	3001	5	that	that	IN
cord-015021-pol2qm74	3001	6	human	human	JJ
cord-015021-pol2qm74	3001	7	eosinophils	eosinophil	NNS
cord-015021-pol2qm74	3001	8	contain	contain	VBP
cord-015021-pol2qm74	3001	9	preformed	preform	VBN
cord-015021-pol2qm74	3001	10	IL-8	IL-8	NNP
cord-015021-pol2qm74	3001	11	protein	protein	NN
cord-015021-pol2qm74	3001	12	although	although	IN
cord-015021-pol2qm74	3001	13	they	-PRON-	PRP
cord-015021-pol2qm74	3001	14	do	do	VBP
cord-015021-pol2qm74	3001	15	not	not	RB
cord-015021-pol2qm74	3001	16	express	express	VB
cord-015021-pol2qm74	3001	17	mRNA	mrna	NN
cord-015021-pol2qm74	3001	18	for	for	IN
cord-015021-pol2qm74	3001	19	IL-8	IL-8	NNP
cord-015021-pol2qm74	3001	20	as	as	IN
cord-015021-pol2qm74	3001	21	measured	measure	VBN
cord-015021-pol2qm74	3001	22	by	by	IN
cord-015021-pol2qm74	3001	23	RT	RT	NNP
cord-015021-pol2qm74	3001	24	-	-	HYPH
cord-015021-pol2qm74	3001	25	PCR	PCR	NNP
cord-015021-pol2qm74	3001	26	.	.	.
cord-015021-pol2qm74	3002	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	3003	1	protein	protein	NN
cord-015021-pol2qm74	3003	2	expression	expression	NN
cord-015021-pol2qm74	3003	3	was	be	VBD
cord-015021-pol2qm74	3003	4	determined	determine	VBN
cord-015021-pol2qm74	3003	5	using	use	VBG
cord-015021-pol2qm74	3003	6	specific	specific	JJ
cord-015021-pol2qm74	3003	7	anti	anti	JJ
cord-015021-pol2qm74	3003	8	-	-	JJ
cord-015021-pol2qm74	3003	9	human	human	JJ
cord-015021-pol2qm74	3003	10	IL-8	il-8	NN
cord-015021-pol2qm74	3003	11	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	3003	12	antibodies	antibody	NNS
cord-015021-pol2qm74	3003	13	by	by	IN
cord-015021-pol2qm74	3003	14	Western	western	JJ
cord-015021-pol2qm74	3003	15	blotting	blotting	NN
cord-015021-pol2qm74	3003	16	,	,	,
cord-015021-pol2qm74	3003	17	FACS	FACS	NNP
cord-015021-pol2qm74	3003	18	analysis	analysis	NN
cord-015021-pol2qm74	3003	19	and	and	CC
cord-015021-pol2qm74	3003	20	immunohistochemistry	immunohistochemistry	NN
cord-015021-pol2qm74	3003	21	.	.	.
cord-015021-pol2qm74	3004	1	Moreover	moreover	RB
cord-015021-pol2qm74	3004	2	,	,	,
cord-015021-pol2qm74	3004	3	preformed	preformed	JJ
cord-015021-pol2qm74	3004	4	IL-8	IL-8	NNP
cord-015021-pol2qm74	3004	5	was	be	VBD
cord-015021-pol2qm74	3004	6	re	re	VBN
cord-015021-pol2qm74	3004	7	/	/	NN
cord-015021-pol2qm74	3004	8	eased	ease	VBD
cord-015021-pol2qm74	3004	9	into	into	IN
cord-015021-pol2qm74	3004	10	supernatant	supernatant	NN
cord-015021-pol2qm74	3004	11	by	by	IN
cord-015021-pol2qm74	3004	12	99	99	CD
cord-015021-pol2qm74	3004	13	%	%	NN
cord-015021-pol2qm74	3004	14	pure	pure	JJ
cord-015021-pol2qm74	3004	15	eosinophils	eosinophil	NNS
cord-015021-pol2qm74	3004	16	after	after	IN
cord-015021-pol2qm74	3004	17	priming	prime	VBG
cord-015021-pol2qm74	3004	18	with	with	IN
cord-015021-pol2qm74	3004	19	GM	GM	NNP
cord-015021-pol2qm74	3004	20	-	-	HYPH
cord-015021-pol2qm74	3004	21	CSF	CSF	NNP
cord-015021-pol2qm74	3004	22	or	or	CC
cord-015021-pol2qm74	3005	1	IL-5	IL-5	NNP
cord-015021-pol2qm74	3005	2	and	and	CC
cord-015021-pol2qm74	3005	3	subsequent	subsequent	JJ
cord-015021-pol2qm74	3005	4	25-min	25-min	CD
cord-015021-pol2qm74	3005	5	stimulation	stimulation	NN
cord-015021-pol2qm74	3005	6	with	with	IN
cord-015021-pol2qm74	3005	7	PAF	PAF	NNP
cord-015021-pol2qm74	3005	8	,	,	,
cord-015021-pol2qm74	3005	9	RANTES	RANTES	NNP
cord-015021-pol2qm74	3005	10	,	,	,
cord-015021-pol2qm74	3005	11	ionomycin	ionomycin	NNS
cord-015021-pol2qm74	3005	12	or	or	CC
cord-015021-pol2qm74	3005	13	PMA	PMA	NNP
cord-015021-pol2qm74	3005	14	,	,	,
cord-015021-pol2qm74	3005	15	however	however	RB
cord-015021-pol2qm74	3005	16	not	not	RB
cord-015021-pol2qm74	3005	17	with	with	IN
cord-015021-pol2qm74	3006	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	3006	2	or	or	CC
cord-015021-pol2qm74	3006	3	IL-2	IL-2	NNP
cord-015021-pol2qm74	3006	4	,	,	,
cord-015021-pol2qm74	3006	5	as	as	IN
cord-015021-pol2qm74	3006	6	measured	measure	VBN
cord-015021-pol2qm74	3006	7	by	by	IN
cord-015021-pol2qm74	3006	8	ELISA	ELISA	NNP
cord-015021-pol2qm74	3006	9	.	.	.
cord-015021-pol2qm74	3007	1	This	this	DT
cord-015021-pol2qm74	3007	2	observation	observation	NN
cord-015021-pol2qm74	3007	3	implies	imply	VBZ
cord-015021-pol2qm74	3007	4	that	that	IN
cord-015021-pol2qm74	3007	5	activation	activation	NN
cord-015021-pol2qm74	3007	6	of	of	IN
cord-015021-pol2qm74	3007	7	protein	protein	NN
cord-015021-pol2qm74	3007	8	kinase	kinase	NN
cord-015021-pol2qm74	3007	9	C	c	NN
cord-015021-pol2qm74	3007	10	and/or	and/or	CC
cord-015021-pol2qm74	3007	11	intracellular	intracellular	JJ
cord-015021-pol2qm74	3007	12	calcium	calcium	NN
cord-015021-pol2qm74	3007	13	mobilization	mobilization	NN
cord-015021-pol2qm74	3007	14	are	be	VBP
cord-015021-pol2qm74	3007	15	necessary	necessary	JJ
cord-015021-pol2qm74	3007	16	events	event	NNS
cord-015021-pol2qm74	3007	17	for	for	IN
cord-015021-pol2qm74	3007	18	IL-8	IL-8	NNP
cord-015021-pol2qm74	3007	19	release	release	NN
cord-015021-pol2qm74	3007	20	in	in	IN
cord-015021-pol2qm74	3007	21	human	human	JJ
cord-015021-pol2qm74	3007	22	eosinophils	eosinophil	NNS
cord-015021-pol2qm74	3007	23	.	.	.
cord-015021-pol2qm74	3008	1	The	the	DT
cord-015021-pol2qm74	3008	2	determined	determined	JJ
cord-015021-pol2qm74	3008	3	amounts	amount	NNS
cord-015021-pol2qm74	3008	4	of	of	IN
cord-015021-pol2qm74	3008	5	preformed	preformed	JJ
cord-015021-pol2qm74	3008	6	IL-8	IL-8	NNP
cord-015021-pol2qm74	3008	7	protein	protein	NN
cord-015021-pol2qm74	3008	8	was	be	VBD
cord-015021-pol2qm74	3008	9	higher	high	JJR
cord-015021-pol2qm74	3008	10	in	in	IN
cord-015021-pol2qm74	3008	11	patients	patient	NNS
cord-015021-pol2qm74	3008	12	with	with	IN
cord-015021-pol2qm74	3008	13	asthma	asthma	NN
cord-015021-pol2qm74	3008	14	compared	compare	VBN
cord-015021-pol2qm74	3008	15	to	to	IN
cord-015021-pol2qm74	3008	16	normal	normal	JJ
cord-015021-pol2qm74	3008	17	individuals	individual	NNS
cord-015021-pol2qm74	3008	18	suggesting	suggest	VBG
cord-015021-pol2qm74	3008	19	a	a	DT
cord-015021-pol2qm74	3008	20	role	role	NN
cord-015021-pol2qm74	3008	21	for	for	IN
cord-015021-pol2qm74	3008	22	eosinonhi	eosinonhi	NNP
cord-015021-pol2qm74	3008	23	!	!	.
cord-015021-pol2qm74	3009	1	derived	derive	VBN
cord-015021-pol2qm74	3009	2	IL-8	IL-8	NNP
cord-015021-pol2qm74	3009	3	in	in	IN
cord-015021-pol2qm74	3009	4	asthma	asthma	NN
cord-015021-pol2qm74	3009	5	.	.	.
cord-015021-pol2qm74	3010	1	Since	since	IN
cord-015021-pol2qm74	3010	2	the	the	DT
cord-015021-pol2qm74	3010	3	eosinopnit	eosinopnit	NNP
cord-015021-pol2qm74	3010	4	is	be	VBZ
cord-015021-pol2qm74	3010	5	the	the	DT
cord-015021-pol2qm74	3010	6	,	,	,
cord-015021-pol2qm74	3010	7	,	,	,
cord-015021-pol2qm74	3010	8	r~:=z	r~:=z	NNP
cord-015021-pol2qm74	3010	9	~	~	NFP
cord-015021-pol2qm74	3010	10	mmant	mmant	JJ
cord-015021-pol2qm74	3010	11	cell	cell	NN
cord-015021-pol2qm74	3010	12	in	in	IN
cord-015021-pol2qm74	3010	13	the	the	DT
cord-015021-pol2qm74	3010	14	asthmatic	asthmatic	JJ
cord-015021-pol2qm74	3010	15	airways	airways	NNP
cord-015021-pol2qm74	3010	16	,	,	,
cord-015021-pol2qm74	3010	17	we	-PRON-	PRP
cord-015021-pol2qm74	3010	18	determined	determine	VBD
cord-015021-pol2qm74	3010	19	IL-8	IL-8	NNP
cord-015021-pol2qm74	3010	20	concentrations	concentration	NNS
cord-015021-pol2qm74	3010	21	in	in	IN
cord-015021-pol2qm74	3010	22	bronchoaIveolar	bronchoaiveolar	JJ
cord-015021-pol2qm74	3010	23	lavage	lavage	NN
cord-015021-pol2qm74	3010	24	(	(	-LRB-
cord-015021-pol2qm74	3010	25	BAL	bal	NN
cord-015021-pol2qm74	3010	26	.	.	.
cord-015021-pol2qm74	3011	1	~ids	~id	NNS
cord-015021-pol2qm74	3011	2	from	from	IN
cord-015021-pol2qm74	3011	3	normal	normal	JJ
cord-015021-pol2qm74	3011	4	!	!	.
cord-015021-pol2qm74	3012	1	i~.~iJvtduals	i~.~ijvtdual	NNS
cord-015021-pol2qm74	3012	2	and	and	CC
cord-015021-pol2qm74	3012	3	asthmatic	asthmatic	JJ
cord-015021-pol2qm74	3012	4	patients	patient	NNS
cord-015021-pol2qm74	3012	5	.	.	.
cord-015021-pol2qm74	3013	1	Indeed	indeed	RB
cord-015021-pol2qm74	3013	2	,	,	,
cord-015021-pol2qm74	3013	3	IL-8	IL-8	NNP
cord-015021-pol2qm74	3013	4	concentrations	concentration	NNS
cord-015021-pol2qm74	3013	5	in	in	IN
cord-015021-pol2qm74	3013	6	BALs	bal	NNS
cord-015021-pol2qm74	3013	7	from	from	IN
cord-015021-pol2qm74	3013	8	both	both	DT
cord-015021-pol2qm74	3013	9	groups	group	NNS
cord-015021-pol2qm74	3013	10	were	be	VBD
cord-015021-pol2qm74	3013	11	similar	similar	JJ
cord-015021-pol2qm74	3013	12	to	to	IN
cord-015021-pol2qm74	3013	13	those	those	DT
cord-015021-pol2qm74	3013	14	seen	see	VBN
cord-015021-pol2qm74	3013	15	in	in	IN
cord-015021-pol2qm74	3013	16	the	the	DT
cord-015021-pol2qm74	3013	17	supernatants	supernatant	NNS
cord-015021-pol2qm74	3013	18	released	release	VBN
cord-015021-pol2qm74	3013	19	by	by	IN
cord-015021-pol2qm74	3013	20	activated	activate	VBN
cord-015021-pol2qm74	3013	21	eosinophils	eosinophil	NNS
cord-015021-pol2qm74	3013	22	.	.	.
cord-015021-pol2qm74	3014	1	The	the	DT
cord-015021-pol2qm74	3014	2	role	role	NN
cord-015021-pol2qm74	3014	3	for	for	IN
cord-015021-pol2qm74	3014	4	IL-8	IL-8	NNP
cord-015021-pol2qm74	3014	5	in	in	IN
cord-015021-pol2qm74	3014	6	asthma	asthma	NN
cord-015021-pol2qm74	3014	7	remains	remain	VBZ
cord-015021-pol2qm74	3014	8	to	to	TO
cord-015021-pol2qm74	3014	9	be	be	VB
cord-015021-pol2qm74	3014	10	determined	determine	VBN
cord-015021-pol2qm74	3014	11	.	.	.
cord-015021-pol2qm74	3014	12	 	 	_SP
cord-015021-pol2qm74	3015	1	Based	base	VBN
cord-015021-pol2qm74	3015	2	on	on	IN
cord-015021-pol2qm74	3015	3	a	a	DT
cord-015021-pol2qm74	3015	4	well	well	RB
cord-015021-pol2qm74	3015	5	established	establish	VBN
cord-015021-pol2qm74	3015	6	rat	rat	NN
cord-015021-pol2qm74	3015	7	model	model	NN
cord-015021-pol2qm74	3015	8	named	name	VBN
cord-015021-pol2qm74	3015	9	activity	activity	NN
cord-015021-pol2qm74	3015	10	-	-	HYPH
cord-015021-pol2qm74	3015	11	induced	induce	VBN
cord-015021-pol2qm74	3015	12	ulceration	ulceration	NN
cord-015021-pol2qm74	3015	13	(	(	-LRB-
cord-015021-pol2qm74	3015	14	ASU	ASU	NNP
cord-015021-pol2qm74	3015	15	)	)	-RRB-
cord-015021-pol2qm74	3015	16	or	or	CC
cord-015021-pol2qm74	3015	17	activity	activity	NN
cord-015021-pol2qm74	3015	18	based	base	VBN
cord-015021-pol2qm74	3015	19	anorexia	anorexia	NN
cord-015021-pol2qm74	3015	20	(	(	-LRB-
cord-015021-pol2qm74	3015	21	ABA	ABA	NNP
cord-015021-pol2qm74	3015	22	)	)	-RRB-
cord-015021-pol2qm74	3015	23	,	,	,
cord-015021-pol2qm74	3015	24	we	-PRON-	PRP
cord-015021-pol2qm74	3015	25	have	have	VBP
cord-015021-pol2qm74	3015	26	developed	develop	VBN
cord-015021-pol2qm74	3015	27	a	a	DT
cord-015021-pol2qm74	3015	28	rat	rat	NN
cord-015021-pol2qm74	3015	29	model	model	NN
cord-015021-pol2qm74	3015	30	for	for	IN
cord-015021-pol2qm74	3015	31	chronic	chronic	JJ
cord-015021-pol2qm74	3015	32	stress	stress	NN
cord-015021-pol2qm74	3015	33	.	.	.
cord-015021-pol2qm74	3016	1	Male	male	JJ
cord-015021-pol2qm74	3016	2	rats	rat	NNS
cord-015021-pol2qm74	3016	3	were	be	VBD
cord-015021-pol2qm74	3016	4	exposed	expose	VBN
cord-015021-pol2qm74	3016	5	to	to	IN
cord-015021-pol2qm74	3016	6	a	a	DT
cord-015021-pol2qm74	3016	7	feeding	feeding	NN
cord-015021-pol2qm74	3016	8	schedule	schedule	NN
cord-015021-pol2qm74	3016	9	in	in	IN
cord-015021-pol2qm74	3016	10	order	order	NN
cord-015021-pol2qm74	3016	11	to	to	TO
cord-015021-pol2qm74	3016	12	reduce	reduce	VB
cord-015021-pol2qm74	3016	13	body	body	NN
cord-015021-pol2qm74	3016	14	weight	weight	NN
cord-015021-pol2qm74	3016	15	by	by	IN
cord-015021-pol2qm74	3016	16	20	20	CD
cord-015021-pol2qm74	3016	17	-	-	SYM
cord-015021-pol2qm74	3016	18	30	30	CD
cord-015021-pol2qm74	3016	19	%	%	NN
cord-015021-pol2qm74	3016	20	within	within	IN
cord-015021-pol2qm74	3016	21	14	14	CD
cord-015021-pol2qm74	3016	22	days	day	NNS
cord-015021-pol2qm74	3016	23	.	.	.
cord-015021-pol2qm74	3017	1	While	while	IN
cord-015021-pol2qm74	3017	2	one	one	CD
cord-015021-pol2qm74	3017	3	group	group	NN
cord-015021-pol2qm74	3017	4	of	of	IN
cord-015021-pol2qm74	3017	5	rats	rat	NNS
cord-015021-pol2qm74	3017	6	was	be	VBD
cord-015021-pol2qm74	3017	7	kept	keep	VBN
cord-015021-pol2qm74	3017	8	sedentary	sedentary	JJ
cord-015021-pol2qm74	3017	9	,	,	,
cord-015021-pol2qm74	3017	10	the	the	DT
cord-015021-pol2qm74	3017	11	other	other	JJ
cord-015021-pol2qm74	3017	12	had	have	VBD
cord-015021-pol2qm74	3017	13	access	access	NN
cord-015021-pol2qm74	3017	14	to	to	IN
cord-015021-pol2qm74	3017	15	a	a	DT
cord-015021-pol2qm74	3017	16	running	run	VBG
cord-015021-pol2qm74	3017	17	wheel	wheel	NN
cord-015021-pol2qm74	3017	18	.	.	.
cord-015021-pol2qm74	3018	1	Food	food	NN
cord-015021-pol2qm74	3018	2	restricted	restrict	VBN
cord-015021-pol2qm74	3018	3	rats	rat	NNS
cord-015021-pol2qm74	3018	4	allowed	allow	VBN
cord-015021-pol2qm74	3018	5	to	to	TO
cord-015021-pol2qm74	3018	6	exercise	exercise	VB
cord-015021-pol2qm74	3018	7	developed	develop	VBN
cord-015021-pol2qm74	3018	8	highly	highly	RB
cord-015021-pol2qm74	3018	9	increased	increase	VBN
cord-015021-pol2qm74	3018	10	activity	activity	NN
cord-015021-pol2qm74	3018	11	as	as	IN
cord-015021-pol2qm74	3018	12	compared	compare	VBN
cord-015021-pol2qm74	3018	13	to	to	IN
cord-015021-pol2qm74	3018	14	ad	ad	NN
cord-015021-pol2qm74	3018	15	libitum	libitum	FW
cord-015021-pol2qm74	3018	16	fed	feed	VBD
cord-015021-pol2qm74	3018	17	rats	rat	NNS
cord-015021-pol2qm74	3018	18	in	in	IN
cord-015021-pol2qm74	3018	19	wheels	wheel	NNS
cord-015021-pol2qm74	3018	20	(	(	-LRB-
cord-015021-pol2qm74	3018	21	ca	ca	UH
cord-015021-pol2qm74	3018	22	.	.	.
cord-015021-pol2qm74	3019	1	15	15	CD
cord-015021-pol2qm74	3020	1	versus	versus	IN
cord-015021-pol2qm74	3020	2	2	2	CD
cord-015021-pol2qm74	3020	3	kin	kin	NNP
cord-015021-pol2qm74	3020	4	/	/	SYM
cord-015021-pol2qm74	3020	5	day	day	NN
cord-015021-pol2qm74	3020	6	)	)	-RRB-
cord-015021-pol2qm74	3020	7	.	.	.
cord-015021-pol2qm74	3021	1	They	-PRON-	PRP
cord-015021-pol2qm74	3021	2	developed	develop	VBD
cord-015021-pol2qm74	3021	3	elevated	elevated	JJ
cord-015021-pol2qm74	3021	4	plasma	plasma	NN
cord-015021-pol2qm74	3021	5	corticosterone	corticosterone	NN
cord-015021-pol2qm74	3021	6	levels	level	NNS
cord-015021-pol2qm74	3021	7	(	(	-LRB-
cord-015021-pol2qm74	3021	8	30_+5gg	30_+5gg	NNP
cord-015021-pol2qm74	3021	9	/	/	SYM
cord-015021-pol2qm74	3021	10	dl	dl	NNP
cord-015021-pol2qm74	3021	11	)	)	-RRB-
cord-015021-pol2qm74	3021	12	at	at	IN
cord-015021-pol2qm74	3021	13	their	-PRON-	PRP$
cord-015021-pol2qm74	3021	14	circadian	circadian	NN
cord-015021-pol2qm74	3021	15	peak	peak	NN
cord-015021-pol2qm74	3021	16	,	,	,
cord-015021-pol2qm74	3021	17	increased	increased	JJ
cord-015021-pol2qm74	3021	18	adrenal	adrenal	JJ
cord-015021-pol2qm74	3021	19	weight	weight	NN
cord-015021-pol2qm74	3021	20	and	and	CC
cord-015021-pol2qm74	3021	21	decreased	decrease	VBD
cord-015021-pol2qm74	3021	22	thymus	thymus	NN
cord-015021-pol2qm74	3021	23	and	and	CC
cord-015021-pol2qm74	3021	24	spleen	spleen	NN
cord-015021-pol2qm74	3021	25	weight	weight	NN
cord-015021-pol2qm74	3021	26	as	as	IN
cord-015021-pol2qm74	3021	27	compared	compare	VBN
cord-015021-pol2qm74	3021	28	to	to	TO
cord-015021-pol2qm74	3021	29	control	control	VB
cord-015021-pol2qm74	3021	30	rats	rat	NNS
cord-015021-pol2qm74	3021	31	and	and	CC
cord-015021-pol2qm74	3021	32	weight	weight	NN
cord-015021-pol2qm74	3021	33	matched	match	VBD
cord-015021-pol2qm74	3021	34	sedentary	sedentary	JJ
cord-015021-pol2qm74	3021	35	rats	rat	NNS
cord-015021-pol2qm74	3021	36	,	,	,
cord-015021-pol2qm74	3021	37	establishing	establish	VBG
cord-015021-pol2qm74	3021	38	this	this	DT
cord-015021-pol2qm74	3021	39	paradigm	paradigm	NN
cord-015021-pol2qm74	3021	40	as	as	IN
cord-015021-pol2qm74	3021	41	a	a	DT
cord-015021-pol2qm74	3021	42	model	model	NN
cord-015021-pol2qm74	3021	43	of	of	IN
cord-015021-pol2qm74	3021	44	chronic	chronic	JJ
cord-015021-pol2qm74	3021	45	stress	stress	NN
cord-015021-pol2qm74	3021	46	.	.	.
cord-015021-pol2qm74	3022	1	No	no	DT
cord-015021-pol2qm74	3022	2	differences	difference	NNS
cord-015021-pol2qm74	3022	3	in	in	IN
cord-015021-pol2qm74	3022	4	plasma	plasma	NN
cord-015021-pol2qm74	3022	5	ACTH	ACTH	NNP
cord-015021-pol2qm74	3022	6	were	be	VBD
cord-015021-pol2qm74	3022	7	seen	see	VBN
cord-015021-pol2qm74	3022	8	among	among	IN
cord-015021-pol2qm74	3022	9	the	the	DT
cord-015021-pol2qm74	3022	10	various	various	JJ
cord-015021-pol2qm74	3022	11	groups	group	NNS
cord-015021-pol2qm74	3022	12	,	,	,
cord-015021-pol2qm74	3022	13	suggesting	suggest	VBG
cord-015021-pol2qm74	3022	14	increased	increase	VBN
cord-015021-pol2qm74	3022	15	sensitivity	sensitivity	NN
cord-015021-pol2qm74	3022	16	of	of	IN
cord-015021-pol2qm74	3022	17	the	the	DT
cord-015021-pol2qm74	3022	18	adrenal	adrenal	JJ
cord-015021-pol2qm74	3022	19	glands	gland	NNS
cord-015021-pol2qm74	3022	20	to	to	IN
cord-015021-pol2qm74	3022	21	ACTH	ACTH	NNP
cord-015021-pol2qm74	3022	22	.	.	.
cord-015021-pol2qm74	3023	1	The	the	DT
cord-015021-pol2qm74	3023	2	effect	effect	NN
cord-015021-pol2qm74	3023	3	of	of	IN
cord-015021-pol2qm74	3023	4	chronic	chronic	JJ
cord-015021-pol2qm74	3023	5	stress	stress	NN
cord-015021-pol2qm74	3023	6	accompanied	accompany	VBN
cord-015021-pol2qm74	3023	7	by	by	IN
cord-015021-pol2qm74	3023	8	hypercorticism	hypercorticism	NN
cord-015021-pol2qm74	3023	9	on	on	IN
cord-015021-pol2qm74	3023	10	baseline	baseline	NN
cord-015021-pol2qm74	3023	11	and	and	CC
cord-015021-pol2qm74	3023	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3023	13	-	-	HYPH
cord-015021-pol2qm74	3023	14	induced	induce	VBN
cord-015021-pol2qm74	3023	15	cytokine	cytokine	NN
cord-015021-pol2qm74	3023	16	levels	level	NNS
cord-015021-pol2qm74	3023	17	was	be	VBD
cord-015021-pol2qm74	3023	18	studied	study	VBN
cord-015021-pol2qm74	3023	19	in	in	IN
cord-015021-pol2qm74	3023	20	this	this	DT
cord-015021-pol2qm74	3023	21	model	model	NN
cord-015021-pol2qm74	3023	22	.	.	.
cord-015021-pol2qm74	3024	1	Under	under	IN
cord-015021-pol2qm74	3024	2	baseline	baseline	JJ
cord-015021-pol2qm74	3024	3	conditions	condition	NNS
cord-015021-pol2qm74	3024	4	,	,	,
cord-015021-pol2qm74	3024	5	splenic	splenic	JJ
cord-015021-pol2qm74	3025	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	3025	2	a	a	DT
cord-015021-pol2qm74	3025	3	was	be	VBD
cord-015021-pol2qm74	3025	4	suppressed	suppress	VBN
cord-015021-pol2qm74	3025	5	in	in	IN
cord-015021-pol2qm74	3025	6	both	both	DT
cord-015021-pol2qm74	3025	7	food	food	NN
cord-015021-pol2qm74	3025	8	-	-	HYPH
cord-015021-pol2qm74	3025	9	restricted	restrict	VBN
cord-015021-pol2qm74	3025	10	groups	group	NNS
cord-015021-pol2qm74	3025	11	.	.	.
cord-015021-pol2qm74	3026	1	This	this	DT
cord-015021-pol2qm74	3026	2	was	be	VBD
cord-015021-pol2qm74	3026	3	more	more	RBR
cord-015021-pol2qm74	3026	4	pronounced	pronounce	VBN
cord-015021-pol2qm74	3026	5	in	in	IN
cord-015021-pol2qm74	3026	6	rats	rat	NNS
cord-015021-pol2qm74	3026	7	with	with	IN
cord-015021-pol2qm74	3026	8	access	access	NN
cord-015021-pol2qm74	3026	9	to	to	IN
cord-015021-pol2qm74	3026	10	a	a	DT
cord-015021-pol2qm74	3026	11	running	run	VBG
cord-015021-pol2qm74	3026	12	wheel	wheel	NN
cord-015021-pol2qm74	3026	13	.	.	.
cord-015021-pol2qm74	3027	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3027	2	and	and	CC
cord-015021-pol2qm74	3027	3	TNF	TNF	NNP
cord-015021-pol2qm74	3027	4	activity	activity	NN
cord-015021-pol2qm74	3027	5	in	in	IN
cord-015021-pol2qm74	3027	6	plasma	plasma	NN
cord-015021-pol2qm74	3027	7	was	be	VBD
cord-015021-pol2qm74	3027	8	not	not	RB
cord-015021-pol2qm74	3027	9	affected	affect	VBN
cord-015021-pol2qm74	3027	10	.	.	.
cord-015021-pol2qm74	3028	1	After	after	IN
cord-015021-pol2qm74	3028	2	administration	administration	NN
cord-015021-pol2qm74	3028	3	of	of	IN
cord-015021-pol2qm74	3028	4	1001.tg/kg	1001.tg/kg	NNP
cord-015021-pol2qm74	3028	5	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3028	6	(	(	-LRB-
cord-015021-pol2qm74	3028	7	LPS	LPS	NNP
cord-015021-pol2qm74	3028	8	)	)	-RRB-
cord-015021-pol2qm74	3028	9	,	,	,
cord-015021-pol2qm74	3029	1	TNF	tnf	NN
cord-015021-pol2qm74	3029	2	activity	activity	NN
cord-015021-pol2qm74	3029	3	in	in	IN
cord-015021-pol2qm74	3029	4	plasma	plasma	NN
cord-015021-pol2qm74	3029	5	was	be	VBD
cord-015021-pol2qm74	3029	6	suppressed	suppress	VBN
cord-015021-pol2qm74	3029	7	by	by	IN
cord-015021-pol2qm74	3029	8	food	food	NN
cord-015021-pol2qm74	3029	9	restriction	restriction	NN
cord-015021-pol2qm74	3029	10	but	but	CC
cord-015021-pol2qm74	3029	11	there	there	EX
cord-015021-pol2qm74	3029	12	were	be	VBD
cord-015021-pol2qm74	3029	13	no	no	DT
cord-015021-pol2qm74	3029	14	differences	difference	NNS
cord-015021-pol2qm74	3029	15	between	between	IN
cord-015021-pol2qm74	3029	16	sedentary	sedentary	JJ
cord-015021-pol2qm74	3029	17	or	or	CC
cord-015021-pol2qm74	3029	18	exercising	exercise	VBG
cord-015021-pol2qm74	3029	19	rats	rat	NNS
cord-015021-pol2qm74	3029	20	.	.	.
cord-015021-pol2qm74	3030	1	In	in	IN
cord-015021-pol2qm74	3030	2	addition	addition	NN
cord-015021-pol2qm74	3030	3	,	,	,
cord-015021-pol2qm74	3030	4	no	no	DT
cord-015021-pol2qm74	3030	5	differences	difference	NNS
cord-015021-pol2qm74	3030	6	were	be	VBD
cord-015021-pol2qm74	3030	7	found	find	VBN
cord-015021-pol2qm74	3030	8	among	among	IN
cord-015021-pol2qm74	3030	9	groups	group	NNS
cord-015021-pol2qm74	3030	10	for	for	IN
cord-015021-pol2qm74	3030	11	corticosterone	corticosterone	NN
cord-015021-pol2qm74	3030	12	,	,	,
cord-015021-pol2qm74	3030	13	spleen	spleen	NNS
cord-015021-pol2qm74	3030	14	IL	il	NN
cord-015021-pol2qm74	3030	15	-	-	HYPH
cord-015021-pol2qm74	3030	16	lc~	lc~	NN
cord-015021-pol2qm74	3030	17	and	and	CC
cord-015021-pol2qm74	3030	18	plasma	plasma	NN
cord-015021-pol2qm74	3030	19	IL-6	IL-6	NNP
cord-015021-pol2qm74	3030	20	activity	activity	NN
cord-015021-pol2qm74	3030	21	.	.	.
cord-015021-pol2qm74	3031	1	We	-PRON-	PRP
cord-015021-pol2qm74	3031	2	conclude	conclude	VBP
cord-015021-pol2qm74	3031	3	,	,	,
cord-015021-pol2qm74	3031	4	that	that	IN
cord-015021-pol2qm74	3031	5	the	the	DT
cord-015021-pol2qm74	3031	6	food	food	NN
cord-015021-pol2qm74	3031	7	restriction	restriction	NN
cord-015021-pol2qm74	3031	8	-	-	HYPH
cord-015021-pol2qm74	3031	9	induced	induce	VBN
cord-015021-pol2qm74	3031	10	hyperactive	hyperactive	JJ
cord-015021-pol2qm74	3031	11	rat	rat	NN
cord-015021-pol2qm74	3031	12	model	model	NN
cord-015021-pol2qm74	3031	13	is	be	VBZ
cord-015021-pol2qm74	3031	14	a	a	DT
cord-015021-pol2qm74	3031	15	useful	useful	JJ
cord-015021-pol2qm74	3031	16	model	model	NN
cord-015021-pol2qm74	3031	17	for	for	IN
cord-015021-pol2qm74	3031	18	studies	study	NNS
cord-015021-pol2qm74	3031	19	on	on	IN
cord-015021-pol2qm74	3031	20	the	the	DT
cord-015021-pol2qm74	3031	21	effects	effect	NNS
cord-015021-pol2qm74	3031	22	of	of	IN
cord-015021-pol2qm74	3031	23	chronic	chronic	JJ
cord-015021-pol2qm74	3031	24	stress	stress	NN
cord-015021-pol2qm74	3031	25	.	.	.
cord-015021-pol2qm74	3032	1	In	in	IN
cord-015021-pol2qm74	3032	2	this	this	DT
cord-015021-pol2qm74	3032	3	model	model	NN
cord-015021-pol2qm74	3032	4	,	,	,
cord-015021-pol2qm74	3032	5	under	under	IN
cord-015021-pol2qm74	3032	6	basal	basal	NN
cord-015021-pol2qm74	3032	7	conditions	condition	NNS
cord-015021-pol2qm74	3032	8	IL	IL	NNP
cord-015021-pol2qm74	3032	9	-	-	HYPH
cord-015021-pol2qm74	3032	10	le~	le~	NN
cord-015021-pol2qm74	3032	11	in	in	IN
cord-015021-pol2qm74	3032	12	tissues	tissue	NNS
cord-015021-pol2qm74	3032	13	may	may	MD
cord-015021-pol2qm74	3032	14	be	be	VB
cord-015021-pol2qm74	3032	15	subject	subject	JJ
cord-015021-pol2qm74	3032	16	to	to	IN
cord-015021-pol2qm74	3032	17	downregulation	downregulation	NN
cord-015021-pol2qm74	3032	18	by	by	IN
cord-015021-pol2qm74	3032	19	glucocorticoids	glucocorticoid	NNS
cord-015021-pol2qm74	3032	20	,	,	,
cord-015021-pol2qm74	3032	21	whereas	whereas	IN
cord-015021-pol2qm74	3032	22	after	after	IN
cord-015021-pol2qm74	3032	23	LPS	lps	NN
cord-015021-pol2qm74	3032	24	-	-	HYPH
cord-015021-pol2qm74	3032	25	stimulation	stimulation	NN
cord-015021-pol2qm74	3032	26	of	of	IN
cord-015021-pol2qm74	3032	27	cytokine	cytokine	NN
cord-015021-pol2qm74	3032	28	production	production	NN
cord-015021-pol2qm74	3032	29	only	only	RB
cord-015021-pol2qm74	3032	30	TNF	TNF	NNP
cord-015021-pol2qm74	3032	31	activity	activity	NN
cord-015021-pol2qm74	3032	32	is	be	VBZ
cord-015021-pol2qm74	3032	33	regulated	regulate	VBN
cord-015021-pol2qm74	3032	34	by	by	IN
cord-015021-pol2qm74	3032	35	fast	fast	JJ
cord-015021-pol2qm74	3032	36	acting	acting	NN
cord-015021-pol2qm74	3032	37	feedback	feedback	NN
cord-015021-pol2qm74	3032	38	loop	loop	NN
cord-015021-pol2qm74	3032	39	between	between	IN
cord-015021-pol2qm74	3032	40	cytokines	cytokine	NNS
cord-015021-pol2qm74	3032	41	and	and	CC
cord-015021-pol2qm74	3032	42	the	the	DT
cord-015021-pol2qm74	3032	43	hypothalamo	hypothalamo	JJ
cord-015021-pol2qm74	3032	44	-	-	HYPH
cord-015021-pol2qm74	3032	45	pituitary	pituitary	NN
cord-015021-pol2qm74	3032	46	-	-	HYPH
cord-015021-pol2qm74	3032	47	adrenal	adrenal	NN
cord-015021-pol2qm74	3032	48	axis	axis	NN
cord-015021-pol2qm74	3032	49	(	(	-LRB-
cord-015021-pol2qm74	3032	50	HPA	HPA	NNP
cord-015021-pol2qm74	3032	51	-	-	HYPH
cord-015021-pol2qm74	3032	52	axis	axis	NN
cord-015021-pol2qm74	3032	53	)	)	-RRB-
cord-015021-pol2qm74	3032	54	.	.	.
cord-015021-pol2qm74	3033	1	This	this	DT
cord-015021-pol2qm74	3033	2	is	be	VBZ
cord-015021-pol2qm74	3033	3	supported	support	VBN
cord-015021-pol2qm74	3033	4	by	by	IN
cord-015021-pol2qm74	3033	5	strong	strong	JJ
cord-015021-pol2qm74	3033	6	correlations	correlation	NNS
cord-015021-pol2qm74	3033	7	between	between	IN
cord-015021-pol2qm74	3033	8	plasma	plasma	NN
cord-015021-pol2qm74	3033	9	TNF	TNF	NNP
cord-015021-pol2qm74	3033	10	activity	activity	NN
cord-015021-pol2qm74	3033	11	and	and	CC
cord-015021-pol2qm74	3033	12	corticosterone	corticosterone	NN
cord-015021-pol2qm74	3033	13	in	in	IN
cord-015021-pol2qm74	3033	14	stressed	stressed	JJ
cord-015021-pol2qm74	3033	15	rats	rat	NNS
cord-015021-pol2qm74	3033	16	.	.	.
cord-015021-pol2qm74	3034	1	Cytokine	cytokine	NN
cord-015021-pol2qm74	3034	2	antagonists	antagonist	NNS
cord-015021-pol2qm74	3034	3	modulate	modulate	VBP
cord-015021-pol2qm74	3034	4	cytokine	cytokine	JJ
cord-015021-pol2qm74	3034	5	actions	action	NNS
cord-015021-pol2qm74	3034	6	and	and	CC
cord-015021-pol2qm74	3034	7	it	-PRON-	PRP
cord-015021-pol2qm74	3034	8	appears	appear	VBZ
cord-015021-pol2qm74	3034	9	that	that	IN
cord-015021-pol2qm74	3034	10	a	a	DT
cord-015021-pol2qm74	3034	11	balance	balance	NN
cord-015021-pol2qm74	3034	12	between	between	IN
cord-015021-pol2qm74	3034	13	production	production	NN
cord-015021-pol2qm74	3034	14	of	of	IN
cord-015021-pol2qm74	3034	15	cytokines	cytokine	NNS
cord-015021-pol2qm74	3034	16	and	and	CC
cord-015021-pol2qm74	3034	17	cytokine	cytokine	NN
cord-015021-pol2qm74	3034	18	antagonists	antagonist	NNS
cord-015021-pol2qm74	3034	19	is	be	VBZ
cord-015021-pol2qm74	3034	20	important	important	JJ
cord-015021-pol2qm74	3034	21	to	to	TO
cord-015021-pol2qm74	3034	22	control	control	NN
cord-015021-pol2qm74	3034	23	of	of	IN
cord-015021-pol2qm74	3034	24	host	host	NN
cord-015021-pol2qm74	3034	25	responses	response	NNS
cord-015021-pol2qm74	3034	26	.	.	.
cord-015021-pol2qm74	3035	1	Recent	recent	JJ
cord-015021-pol2qm74	3035	2	observations	observation	NNS
cord-015021-pol2qm74	3035	3	show	show	VBP
cord-015021-pol2qm74	3035	4	that	that	IN
cord-015021-pol2qm74	3035	5	during	during	IN
cord-015021-pol2qm74	3035	6	myocardial	myocardial	JJ
cord-015021-pol2qm74	3035	7	infarction	infarction	NN
cord-015021-pol2qm74	3035	8	there	there	EX
cord-015021-pol2qm74	3035	9	is	be	VBZ
cord-015021-pol2qm74	3035	10	an	an	DT
cord-015021-pol2qm74	3035	11	increase	increase	NN
cord-015021-pol2qm74	3035	12	in	in	IN
cord-015021-pol2qm74	3035	13	circulating	circulate	VBG
cord-015021-pol2qm74	3035	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	3035	15	such	such	JJ
cord-015021-pol2qm74	3035	16	as	as	IN
cord-015021-pol2qm74	3035	17	tumor	tumor	NN
cord-015021-pol2qm74	3035	18	necrosis	necrosis	NN
cord-015021-pol2qm74	3035	19	factor	factor	NN
cord-015021-pol2qm74	3035	20	(	(	-LRB-
cord-015021-pol2qm74	3035	21	TNF	TNF	NNP
cord-015021-pol2qm74	3035	22	)	)	-RRB-
cord-015021-pol2qm74	3035	23	and	and	CC
cord-015021-pol2qm74	3035	24	interleukin	interleukin	NN
cord-015021-pol2qm74	3035	25	6	6	CD
cord-015021-pol2qm74	3035	26	(	(	-LRB-
cord-015021-pol2qm74	3035	27	IL-6	IL-6	NNP
cord-015021-pol2qm74	3035	28	)	)	-RRB-
cord-015021-pol2qm74	3035	29	.	.	.
cord-015021-pol2qm74	3036	1	We	-PRON-	PRP
cord-015021-pol2qm74	3036	2	tested	test	VBD
cord-015021-pol2qm74	3036	3	the	the	DT
cord-015021-pol2qm74	3036	4	idea	idea	NN
cord-015021-pol2qm74	3036	5	that	that	IN
cord-015021-pol2qm74	3036	6	compensatory	compensatory	JJ
cord-015021-pol2qm74	3036	7	increases	increase	NNS
cord-015021-pol2qm74	3036	8	in	in	IN
cord-015021-pol2qm74	3036	9	cytokine	cytokine	NN
cord-015021-pol2qm74	3036	10	antagonists	antagonist	NNS
cord-015021-pol2qm74	3036	11	likewise	likewise	RB
cord-015021-pol2qm74	3036	12	occur	occur	VBP
cord-015021-pol2qm74	3036	13	and	and	CC
cord-015021-pol2qm74	3036	14	investigated	investigate	VBN
cord-015021-pol2qm74	3036	15	changes	change	NNS
cord-015021-pol2qm74	3036	16	in	in	IN
cord-015021-pol2qm74	3036	17	plasma	plasma	NN
cord-015021-pol2qm74	3036	18	concentrations	concentration	NNS
cord-015021-pol2qm74	3036	19	of	of	IN
cord-015021-pol2qm74	3036	20	TNF	TNF	NNP
cord-015021-pol2qm74	3036	21	and	and	CC
cord-015021-pol2qm74	3036	22	interleukin	interleukin	NN
cord-015021-pol2qm74	3036	23	i	i	NNP
cord-015021-pol2qm74	3036	24	(	(	-LRB-
cord-015021-pol2qm74	3036	25	IL-1	IL-1	NNP
cord-015021-pol2qm74	3036	26	)	)	-RRB-
cord-015021-pol2qm74	3036	27	and	and	CC
cord-015021-pol2qm74	3036	28	those	those	DT
cord-015021-pol2qm74	3036	29	of	of	IN
cord-015021-pol2qm74	3036	30	their	-PRON-	PRP$
cord-015021-pol2qm74	3036	31	specific	specific	JJ
cord-015021-pol2qm74	3036	32	antagonists	antagonist	NNS
cord-015021-pol2qm74	3036	33	interleukin-1	interleukin-1	NNP
cord-015021-pol2qm74	3036	34	receptor	receptor	NN
cord-015021-pol2qm74	3036	35	antagonist	antagonist	NN
cord-015021-pol2qm74	3036	36	(	(	-LRB-
cord-015021-pol2qm74	3036	37	IL-1	IL-1	NNP
cord-015021-pol2qm74	3036	38	ra	ra	NNP
cord-015021-pol2qm74	3036	39	)	)	-RRB-
cord-015021-pol2qm74	3036	40	and	and	CC
cord-015021-pol2qm74	3036	41	soluble	soluble	JJ
cord-015021-pol2qm74	3036	42	tumor	tumor	NN
cord-015021-pol2qm74	3036	43	necrosis	necrosis	NN
cord-015021-pol2qm74	3036	44	factor	factor	NN
cord-015021-pol2qm74	3036	45	receptor	receptor	NN
cord-015021-pol2qm74	3036	46	type	type	NN
cord-015021-pol2qm74	3036	47	I	-PRON-	PRP
cord-015021-pol2qm74	3036	48	(	(	-LRB-
cord-015021-pol2qm74	3036	49	s	s	VBZ
cord-015021-pol2qm74	3036	50	TNF	TNF	NNP
cord-015021-pol2qm74	3036	51	r	r	NN
cord-015021-pol2qm74	3036	52	-	-	:
cord-015021-pol2qm74	3036	53	I	I	NNP
cord-015021-pol2qm74	3036	54	)	)	-RRB-
cord-015021-pol2qm74	3036	55	.	.	.
cord-015021-pol2qm74	3037	1	We	-PRON-	PRP
cord-015021-pol2qm74	3037	2	also	also	RB
cord-015021-pol2qm74	3037	3	measured	measure	VBD
cord-015021-pol2qm74	3037	4	plasma	plasma	NN
cord-015021-pol2qm74	3037	5	concentrations	concentration	NNS
cord-015021-pol2qm74	3037	6	of	of	IN
cord-015021-pol2qm74	3037	7	~-melanocyte	~-melanocyte	RB
cord-015021-pol2qm74	3037	8	-	-	HYPH
cord-015021-pol2qm74	3037	9	stimulating	stimulate	VBG
cord-015021-pol2qm74	3037	10	hormone	hormone	NN
cord-015021-pol2qm74	3037	11	(	(	-LRB-
cord-015021-pol2qm74	3037	12	~-MSH	~-MSH	NNP
cord-015021-pol2qm74	3037	13	)	)	-RRB-
cord-015021-pol2qm74	3037	14	,	,	,
cord-015021-pol2qm74	3037	15	an	an	DT
cord-015021-pol2qm74	3037	16	endogenous	endogenous	JJ
cord-015021-pol2qm74	3037	17	neuropeptide	neuropeptide	NN
cord-015021-pol2qm74	3037	18	that	that	WDT
cord-015021-pol2qm74	3037	19	occurs	occur	VBZ
cord-015021-pol2qm74	3037	20	in	in	IN
cord-015021-pol2qm74	3037	21	pituitary	pituitary	NN
cord-015021-pol2qm74	3037	22	,	,	,
cord-015021-pol2qm74	3037	23	brain	brain	NN
cord-015021-pol2qm74	3037	24	,	,	,
cord-015021-pol2qm74	3037	25	skin	skin	NN
cord-015021-pol2qm74	3037	26	,	,	,
cord-015021-pol2qm74	3037	27	gut	gut	NN
cord-015021-pol2qm74	3037	28	and	and	CC
cord-015021-pol2qm74	3037	29	other	other	JJ
cord-015021-pol2qm74	3037	30	tissues	tissue	NNS
cord-015021-pol2qm74	3037	31	.	.	.
cord-015021-pol2qm74	3038	1	When	when	WRB
cord-015021-pol2qm74	3038	2	administered	administer	VBN
cord-015021-pol2qm74	3038	3	to	to	IN
cord-015021-pol2qm74	3038	4	laboratory	laboratory	NN
cord-015021-pol2qm74	3038	5	animals	animal	NNS
cord-015021-pol2qm74	3038	6	,	,	,
cord-015021-pol2qm74	3038	7	this	this	DT
cord-015021-pol2qm74	3038	8	peptide	peptide	NN
cord-015021-pol2qm74	3038	9	has	have	VBZ
cord-015021-pol2qm74	3038	10	potent	potent	JJ
cord-015021-pol2qm74	3038	11	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	3038	12	and	and	CC
cord-015021-pol2qm74	3038	13	antipyretic	antipyretic	JJ
cord-015021-pol2qm74	3038	14	activity	activity	NN
cord-015021-pol2qm74	3038	15	,	,	,
cord-015021-pol2qm74	3038	16	perhaps	perhaps	RB
cord-015021-pol2qm74	3038	17	by	by	IN
cord-015021-pol2qm74	3038	18	mimicking	mimic	VBG
cord-015021-pol2qm74	3038	19	an	an	DT
cord-015021-pol2qm74	3038	20	endogenous	endogenous	JJ
cord-015021-pol2qm74	3038	21	modulatory	modulatory	JJ
cord-015021-pol2qm74	3038	22	influence	influence	NN
cord-015021-pol2qm74	3038	23	on	on	IN
cord-015021-pol2qm74	3038	24	cytokine	cytokine	JJ
cord-015021-pol2qm74	3038	25	actions	action	NNS
cord-015021-pol2qm74	3038	26	.	.	.
cord-015021-pol2qm74	3039	1	Samples	sample	NNS
cord-015021-pol2qm74	3039	2	were	be	VBD
cord-015021-pol2qm74	3039	3	obtained	obtain	VBN
cord-015021-pol2qm74	3039	4	from	from	IN
cord-015021-pol2qm74	3039	5	20	20	CD
cord-015021-pol2qm74	3039	6	patients	patient	NNS
cord-015021-pol2qm74	3039	7	with	with	IN
cord-015021-pol2qm74	3039	8	acute	acute	JJ
cord-015021-pol2qm74	3039	9	myocardial	myocardial	JJ
cord-015021-pol2qm74	3039	10	infarction	infarction	NN
cord-015021-pol2qm74	3039	11	at	at	IN
cord-015021-pol2qm74	3039	12	presentation	presentation	NN
cord-015021-pol2qm74	3039	13	in	in	IN
cord-015021-pol2qm74	3039	14	the	the	DT
cord-015021-pol2qm74	3039	15	Coronary	Coronary	NNP
cord-015021-pol2qm74	3039	16	Unit	Unit	NNP
cord-015021-pol2qm74	3039	17	,	,	,
cord-015021-pol2qm74	3039	18	every	every	DT
cord-015021-pol2qm74	3039	19	three	three	CD
cord-015021-pol2qm74	3039	20	hours	hour	NNS
cord-015021-pol2qm74	3039	21	for	for	IN
cord-015021-pol2qm74	3039	22	24	24	CD
cord-015021-pol2qm74	3039	23	hours	hour	NNS
cord-015021-pol2qm74	3039	24	,	,	,
cord-015021-pol2qm74	3039	25	and	and	CC
cord-015021-pol2qm74	3039	26	daily	daily	RB
cord-015021-pol2qm74	3039	27	thereafter	thereafter	RB
cord-015021-pol2qm74	3039	28	until	until	IN
cord-015021-pol2qm74	3039	29	discharge	discharge	NN
cord-015021-pol2qm74	3039	30	.	.	.
cord-015021-pol2qm74	3040	1	We	-PRON-	PRP
cord-015021-pol2qm74	3040	2	found	find	VBD
cord-015021-pol2qm74	3040	3	elevations	elevation	NNS
cord-015021-pol2qm74	3040	4	in	in	IN
cord-015021-pol2qm74	3040	5	the	the	DT
cord-015021-pol2qm74	3040	6	plasma	plasma	NN
cord-015021-pol2qm74	3040	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	3040	8	IL-1	IL-1	NNP
cord-015021-pol2qm74	3040	9	and	and	CC
cord-015021-pol2qm74	3040	10	TNF	TNF	NNP
cord-015021-pol2qm74	3040	11	only	only	RB
cord-015021-pol2qm74	3040	12	in	in	IN
cord-015021-pol2qm74	3040	13	a	a	DT
cord-015021-pol2qm74	3040	14	proportion	proportion	NN
cord-015021-pol2qm74	3040	15	of	of	IN
cord-015021-pol2qm74	3040	16	subjects	subject	NNS
cord-015021-pol2qm74	3040	17	whereas	whereas	IN
cord-015021-pol2qm74	3040	18	cytokine	cytokine	NN
cord-015021-pol2qm74	3040	19	antagonists	antagonist	NNS
cord-015021-pol2qm74	3040	20	c~-MSH	c~-msh	VBP
cord-015021-pol2qm74	3040	21	,	,	,
cord-015021-pol2qm74	3040	22	IL	IL	NNP
cord-015021-pol2qm74	3040	23	-	-	HYPH
cord-015021-pol2qm74	3040	24	lra	lra	NNP
cord-015021-pol2qm74	3040	25	,	,	,
cord-015021-pol2qm74	3040	26	and	and	CC
cord-015021-pol2qm74	3040	27	sTNFr	stnfr	CD
cord-015021-pol2qm74	3040	28	were	be	VBD
cord-015021-pol2qm74	3040	29	elevated	elevate	VBN
cord-015021-pol2qm74	3040	30	in	in	IN
cord-015021-pol2qm74	3040	31	all	all	DT
cord-015021-pol2qm74	3040	32	patients	patient	NNS
cord-015021-pol2qm74	3040	33	,	,	,
cord-015021-pol2qm74	3040	34	o~-MSH	o~-MSH	NNP
cord-015021-pol2qm74	3040	35	was	be	VBD
cord-015021-pol2qm74	3040	36	elevated	elevate	VBN
cord-015021-pol2qm74	3040	37	at	at	IN
cord-015021-pol2qm74	3040	38	presentation	presentation	NN
cord-015021-pol2qm74	3040	39	but	but	CC
cord-015021-pol2qm74	3040	40	it	-PRON-	PRP
cord-015021-pol2qm74	3040	41	decreased	decrease	VBD
cord-015021-pol2qm74	3040	42	progressively	progressively	RB
cord-015021-pol2qm74	3040	43	in	in	IN
cord-015021-pol2qm74	3040	44	successive	successive	JJ
cord-015021-pol2qm74	3040	45	tests	test	NNS
cord-015021-pol2qm74	3040	46	,	,	,
cord-015021-pol2qm74	3040	47	reaching	reach	VBG
cord-015021-pol2qm74	3040	48	normal	normal	JJ
cord-015021-pol2qm74	3040	49	values	value	NNS
cord-015021-pol2qm74	3040	50	within	within	IN
cord-015021-pol2qm74	3040	51	24	24	CD
cord-015021-pol2qm74	3040	52	hr	hr	NN
cord-015021-pol2qm74	3040	53	whereas	whereas	IN
cord-015021-pol2qm74	3040	54	sTNFr	stnfr	XX
cord-015021-pol2qm74	3040	55	and	and	CC
cord-015021-pol2qm74	3040	56	1L	1l	CD
cord-015021-pol2qm74	3040	57	-	-	HYPH
cord-015021-pol2qm74	3040	58	lra	lra	NNP
cord-015021-pol2qm74	3040	59	peaked	peak	VBD
cord-015021-pol2qm74	3040	60	at	at	IN
cord-015021-pol2qm74	3040	61	3	3	CD
cord-015021-pol2qm74	3040	62	-	-	SYM
cord-015021-pol2qm74	3040	63	6	6	CD
cord-015021-pol2qm74	3040	64	hr	hr	NN
cord-015021-pol2qm74	3040	65	or	or	CC
cord-015021-pol2qm74	3040	66	later	later	RB
cord-015021-pol2qm74	3040	67	.	.	.
cord-015021-pol2qm74	3041	1	There	there	EX
cord-015021-pol2qm74	3041	2	were	be	VBD
cord-015021-pol2qm74	3041	3	significant	significant	JJ
cord-015021-pol2qm74	3041	4	correlations	correlation	NNS
cord-015021-pol2qm74	3041	5	between	between	IN
cord-015021-pol2qm74	3041	6	plasma	plasma	NN
cord-015021-pol2qm74	3041	7	concentrations	concentration	NNS
cord-015021-pol2qm74	3041	8	of	of	IN
cord-015021-pol2qm74	3041	9	cytokine	cytokine	JJ
cord-015021-pol2qm74	3041	10	antagonists	antagonist	NNS
cord-015021-pol2qm74	3041	11	and	and	CC
cord-015021-pol2qm74	3041	12	enzymes	enzyme	NNS
cord-015021-pol2qm74	3041	13	released	release	VBN
cord-015021-pol2qm74	3041	14	from	from	IN
cord-015021-pol2qm74	3041	15	injured	injured	JJ
cord-015021-pol2qm74	3041	16	myocardium	myocardium	NN
cord-015021-pol2qm74	3041	17	,	,	,
cord-015021-pol2qm74	3041	18	including	include	VBG
cord-015021-pol2qm74	3041	19	creatine	creatine	NN
cord-015021-pol2qm74	3041	20	kinase	kinase	NN
cord-015021-pol2qm74	3041	21	(	(	-LRB-
cord-015021-pol2qm74	3041	22	CK	CK	NNP
cord-015021-pol2qm74	3041	23	)	)	-RRB-
cord-015021-pol2qm74	3041	24	,	,	,
cord-015021-pol2qm74	3041	25	aspartate	aspartate	NN
cord-015021-pol2qm74	3041	26	serum	serum	NN
cord-015021-pol2qm74	3041	27	transferase	transferase	NN
cord-015021-pol2qm74	3041	28	(	(	-LRB-
cord-015021-pol2qm74	3041	29	AST	AST	NNP
cord-015021-pol2qm74	3041	30	)	)	-RRB-
cord-015021-pol2qm74	3041	31	,	,	,
cord-015021-pol2qm74	3041	32	and	and	CC
cord-015021-pol2qm74	3041	33	lactate	lactate	NN
cord-015021-pol2qm74	3041	34	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	3041	35	(	(	-LRB-
cord-015021-pol2qm74	3041	36	LDH	LDH	NNP
cord-015021-pol2qm74	3041	37	)	)	-RRB-
cord-015021-pol2qm74	3041	38	.	.	.
cord-015021-pol2qm74	3042	1	The	the	DT
cord-015021-pol2qm74	3042	2	data	datum	NNS
cord-015021-pol2qm74	3042	3	show	show	VBP
cord-015021-pol2qm74	3042	4	that	that	IN
cord-015021-pol2qm74	3042	5	cytokine	cytokine	NN
cord-015021-pol2qm74	3042	6	antagonists	antagonist	NNS
cord-015021-pol2qm74	3042	7	increase	increase	VBP
cord-015021-pol2qm74	3042	8	in	in	IN
cord-015021-pol2qm74	3042	9	the	the	DT
cord-015021-pol2qm74	3042	10	circulation	circulation	NN
cord-015021-pol2qm74	3042	11	of	of	IN
cord-015021-pol2qm74	3042	12	patients	patient	NNS
cord-015021-pol2qm74	3042	13	with	with	IN
cord-015021-pol2qm74	3042	14	acute	acute	JJ
cord-015021-pol2qm74	3042	15	myocardial	myocardial	JJ
cord-015021-pol2qm74	3042	16	infarction	infarction	NN
cord-015021-pol2qm74	3042	17	likely	likely	JJ
cord-015021-pol2qm74	3042	18	to	to	TO
cord-015021-pol2qm74	3042	19	modulate	modulate	VB
cord-015021-pol2qm74	3042	20	prninflammatory	prninflammatory	NN
cord-015021-pol2qm74	3042	21	effects	effect	NNS
cord-015021-pol2qm74	3042	22	of	of	IN
cord-015021-pol2qm74	3042	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	3042	24	.	.	.
cord-015021-pol2qm74	3043	1	Objects	object	NNS
cord-015021-pol2qm74	3043	2	of	of	IN
cord-015021-pol2qm74	3043	3	the	the	DT
cord-015021-pol2qm74	3043	4	study	study	NN
cord-015021-pol2qm74	3043	5	:	:	:
cord-015021-pol2qm74	3043	6	Interleukin-6	Interleukin-6	NNP
cord-015021-pol2qm74	3043	7	(	(	-LRB-
cord-015021-pol2qm74	3043	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	3043	9	)	)	-RRB-
cord-015021-pol2qm74	3043	10	is	be	VBZ
cord-015021-pol2qm74	3043	11	a	a	DT
cord-015021-pol2qm74	3043	12	multifunctionai	multifunctionai	JJ
cord-015021-pol2qm74	3043	13	cytokine	cytokine	NN
cord-015021-pol2qm74	3043	14	known	know	VBN
cord-015021-pol2qm74	3043	15	to	to	TO
cord-015021-pol2qm74	3043	16	be	be	VB
cord-015021-pol2qm74	3043	17	involved	involve	VBN
cord-015021-pol2qm74	3043	18	in	in	IN
cord-015021-pol2qm74	3043	19	important	important	JJ
cord-015021-pol2qm74	3043	20	homeostatic	homeostatic	JJ
cord-015021-pol2qm74	3043	21	processes	process	NNS
cord-015021-pol2qm74	3043	22	.	.	.
cord-015021-pol2qm74	3044	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3044	2	levels	level	NNS
cord-015021-pol2qm74	3044	3	are	be	VBP
cord-015021-pol2qm74	3044	4	increased	increase	VBN
cord-015021-pol2qm74	3044	5	in	in	IN
cord-015021-pol2qm74	3044	6	many	many	JJ
cord-015021-pol2qm74	3044	7	pathological	pathological	JJ
cord-015021-pol2qm74	3044	8	situations	situation	NNS
cord-015021-pol2qm74	3044	9	,	,	,
cord-015021-pol2qm74	3044	10	and	and	CC
cord-015021-pol2qm74	3044	11	correlates	correlate	VBZ
cord-015021-pol2qm74	3044	12	with	with	IN
cord-015021-pol2qm74	3044	13	disease	disease	NN
cord-015021-pol2qm74	3044	14	activity	activity	NN
cord-015021-pol2qm74	3044	15	and	and	CC
cord-015021-pol2qm74	3044	16	patient	patient	NN
cord-015021-pol2qm74	3044	17	outcome	outcome	NN
cord-015021-pol2qm74	3044	18	.	.	.
cord-015021-pol2qm74	3045	1	To	to	TO
cord-015021-pol2qm74	3045	2	exert	exert	VB
cord-015021-pol2qm74	3045	3	its	-PRON-	PRP$
cord-015021-pol2qm74	3045	4	effect	effect	NN
cord-015021-pol2qm74	3045	5	IL-6	IL-6	NNP
cord-015021-pol2qm74	3045	6	binds	bind	VBZ
cord-015021-pol2qm74	3045	7	to	to	IN
cord-015021-pol2qm74	3045	8	its	-PRON-	PRP$
cord-015021-pol2qm74	3045	9	receptor	receptor	NN
cord-015021-pol2qm74	3045	10	on	on	IN
cord-015021-pol2qm74	3045	11	the	the	DT
cord-015021-pol2qm74	3045	12	membrane	membrane	NN
cord-015021-pol2qm74	3045	13	of	of	IN
cord-015021-pol2qm74	3045	14	its	-PRON-	PRP$
cord-015021-pol2qm74	3045	15	target	target	NN
cord-015021-pol2qm74	3045	16	cell	cell	NN
cord-015021-pol2qm74	3045	17	.	.	.
cord-015021-pol2qm74	3046	1	This	this	DT
cord-015021-pol2qm74	3046	2	receptor	receptor	NN
cord-015021-pol2qm74	3046	3	is	be	VBZ
cord-015021-pol2qm74	3046	4	also	also	RB
cord-015021-pol2qm74	3046	5	present	present	JJ
cord-015021-pol2qm74	3046	6	in	in	IN
cord-015021-pol2qm74	3046	7	a	a	DT
cord-015021-pol2qm74	3046	8	soluble	soluble	JJ
cord-015021-pol2qm74	3046	9	form	form	NN
cord-015021-pol2qm74	3046	10	in	in	IN
cord-015021-pol2qm74	3046	11	plasma	plasma	NN
cord-015021-pol2qm74	3046	12	and	and	CC
cord-015021-pol2qm74	3046	13	in	in	IN
cord-015021-pol2qm74	3046	14	urine	urine	NN
cord-015021-pol2qm74	3046	15	.	.	.
cord-015021-pol2qm74	3047	1	In	in	IN
cord-015021-pol2qm74	3047	2	this	this	DT
cord-015021-pol2qm74	3047	3	study	study	NN
cord-015021-pol2qm74	3047	4	we	-PRON-	PRP
cord-015021-pol2qm74	3047	5	quantitatively	quantitatively	RB
cord-015021-pol2qm74	3047	6	measured	measure	VBD
cord-015021-pol2qm74	3047	7	the	the	DT
cord-015021-pol2qm74	3047	8	availability	availability	NN
cord-015021-pol2qm74	3047	9	of	of	IN
cord-015021-pol2qm74	3047	10	soluble	soluble	JJ
cord-015021-pol2qm74	3047	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	3047	12	receptor	receptor	NN
cord-015021-pol2qm74	3047	13	(	(	-LRB-
cord-015021-pol2qm74	3047	14	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3047	15	)	)	-RRB-
cord-015021-pol2qm74	3047	16	in	in	IN
cord-015021-pol2qm74	3047	17	biological	biological	JJ
cord-015021-pol2qm74	3047	18	fluids	fluid	NNS
cord-015021-pol2qm74	3047	19	in	in	IN
cord-015021-pol2qm74	3047	20	healthy	healthy	JJ
cord-015021-pol2qm74	3047	21	volunteers	volunteer	NNS
cord-015021-pol2qm74	3047	22	.	.	.
cord-015021-pol2qm74	3048	1	Materials	material	NNS
cord-015021-pol2qm74	3048	2	and	and	CC
cord-015021-pol2qm74	3048	3	methods	method	NNS
cord-015021-pol2qm74	3048	4	:	:	:
cord-015021-pol2qm74	3048	5	Blood	blood	NN
cord-015021-pol2qm74	3048	6	,	,	,
cord-015021-pol2qm74	3048	7	urine	urine	NN
cord-015021-pol2qm74	3048	8	,	,	,
cord-015021-pol2qm74	3048	9	cerebrospinal	cerebrospinal	JJ
cord-015021-pol2qm74	3048	10	fluid	fluid	NN
cord-015021-pol2qm74	3048	11	(	(	-LRB-
cord-015021-pol2qm74	3048	12	CSF	CSF	NNP
cord-015021-pol2qm74	3048	13	)	)	-RRB-
cord-015021-pol2qm74	3048	14	,	,	,
cord-015021-pol2qm74	3048	15	and	and	CC
cord-015021-pol2qm74	3048	16	synovial	synovial	JJ
cord-015021-pol2qm74	3048	17	fluid	fluid	NN
cord-015021-pol2qm74	3048	18	(	(	-LRB-
cord-015021-pol2qm74	3048	19	SF	SF	NNP
cord-015021-pol2qm74	3048	20	)	)	-RRB-
cord-015021-pol2qm74	3048	21	are	be	VBP
cord-015021-pol2qm74	3048	22	obtained	obtain	VBN
cord-015021-pol2qm74	3048	23	from	from	IN
cord-015021-pol2qm74	3048	24	healthy	healthy	JJ
cord-015021-pol2qm74	3048	25	volunteers	volunteer	NNS
cord-015021-pol2qm74	3048	26	,	,	,
cord-015021-pol2qm74	3048	27	sIL-6R	sIL-6R	NNP
cord-015021-pol2qm74	3048	28	and	and	CC
cord-015021-pol2qm74	3048	29	IL-6	IL-6	NNP
cord-015021-pol2qm74	3048	30	are	be	VBP
cord-015021-pol2qm74	3048	31	measured	measure	VBN
cord-015021-pol2qm74	3048	32	using	use	VBG
cord-015021-pol2qm74	3048	33	ELISA	ELISA	NNP
cord-015021-pol2qm74	3048	34	's	's	POS
cord-015021-pol2qm74	3048	35	.	.	.
cord-015021-pol2qm74	3049	1	Both	both	DT
cord-015021-pol2qm74	3049	2	ELISA	ELISA	NNP
cord-015021-pol2qm74	3049	3	's	's	POS
cord-015021-pol2qm74	3049	4	are	be	VBP
cord-015021-pol2qm74	3049	5	tested	test	VBN
cord-015021-pol2qm74	3049	6	for	for	IN
cord-015021-pol2qm74	3049	7	interference	interference	NN
cord-015021-pol2qm74	3049	8	of	of	IN
cord-015021-pol2qm74	3049	9	sIL-6R	sil-6r	NN
cord-015021-pol2qm74	3049	10	mid	mid	NNP
cord-015021-pol2qm74	3049	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	3049	12	.	.	.
cord-015021-pol2qm74	3050	1	The	the	DT
cord-015021-pol2qm74	3050	2	effect	effect	NN
cord-015021-pol2qm74	3050	3	of	of	IN
cord-015021-pol2qm74	3050	4	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3050	5	in	in	IN
cord-015021-pol2qm74	3050	6	the	the	DT
cord-015021-pol2qm74	3050	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	3050	8	bio	bio	NN
cord-015021-pol2qm74	3050	9	-	-	HYPH
cord-015021-pol2qm74	3050	10	assay	assay	NNP
cord-015021-pol2qm74	3050	11	(	(	-LRB-
cord-015021-pol2qm74	3050	12	B9	B9	NNP
cord-015021-pol2qm74	3050	13	)	)	-RRB-
cord-015021-pol2qm74	3050	14	is	be	VBZ
cord-015021-pol2qm74	3050	15	tested	test	VBN
cord-015021-pol2qm74	3050	16	.	.	.
cord-015021-pol2qm74	3051	1	Results	result	NNS
cord-015021-pol2qm74	3051	2	:	:	:
cord-015021-pol2qm74	3052	1	Baseline	baseline	JJ
cord-015021-pol2qm74	3052	2	levels	level	NNS
cord-015021-pol2qm74	3052	3	are	be	VBP
cord-015021-pol2qm74	3052	4	(	(	-LRB-
cord-015021-pol2qm74	3052	5	mean	mean	VB
cord-015021-pol2qm74	3052	6	+	+	CC
cord-015021-pol2qm74	3052	7	SD	sd	NN
cord-015021-pol2qm74	3052	8	)	)	-RRB-
cord-015021-pol2qm74	3052	9	:	:	:
cord-015021-pol2qm74	3052	10	76.6	76.6	CD
cord-015021-pol2qm74	3052	11	-+	-+	NNP
cord-015021-pol2qm74	3052	12	19.3	19.3	CD
cord-015021-pol2qm74	3052	13	ng	ng	NNP
cord-015021-pol2qm74	3052	14	/	/	SYM
cord-015021-pol2qm74	3052	15	ml	ml	NN
cord-015021-pol2qm74	3052	16	in	in	IN
cord-015021-pol2qm74	3052	17	serum	serum	NN
cord-015021-pol2qm74	3052	18	,	,	,
cord-015021-pol2qm74	3052	19	3.7	3.7	CD
cord-015021-pol2qm74	3052	20	-+	-+	NFP
cord-015021-pol2qm74	3052	21	1.3	1.3	CD
cord-015021-pol2qm74	3052	22	ng	ng	NN
cord-015021-pol2qm74	3052	23	/	/	SYM
cord-015021-pol2qm74	3052	24	ml	ml	NN
cord-015021-pol2qm74	3052	25	in	in	IN
cord-015021-pol2qm74	3052	26	urine	urine	NN
cord-015021-pol2qm74	3052	27	,	,	,
cord-015021-pol2qm74	3052	28	1.64	1.64	CD
cord-015021-pol2qm74	3052	29	_	_	NN
cord-015021-pol2qm74	3052	30	+	+	SYM
cord-015021-pol2qm74	3052	31	0.4	0.4	CD
cord-015021-pol2qm74	3052	32	ng	ng	NN
cord-015021-pol2qm74	3052	33	/	/	SYM
cord-015021-pol2qm74	3052	34	ml	ml	NN
cord-015021-pol2qm74	3052	35	in	in	IN
cord-015021-pol2qm74	3052	36	CSF	CSF	NNP
cord-015021-pol2qm74	3052	37	and	and	CC
cord-015021-pol2qm74	3052	38	11.6	11.6	CD
cord-015021-pol2qm74	3052	39	+	+	SYM
cord-015021-pol2qm74	3052	40	3.3	3.3	CD
cord-015021-pol2qm74	3052	41	ng	ng	NN
cord-015021-pol2qm74	3052	42	/	/	SYM
cord-015021-pol2qm74	3052	43	ml	ml	NN
cord-015021-pol2qm74	3052	44	in	in	IN
cord-015021-pol2qm74	3052	45	SF	SF	NNP
cord-015021-pol2qm74	3052	46	.	.	.
cord-015021-pol2qm74	3053	1	There	there	EX
cord-015021-pol2qm74	3053	2	is	be	VBZ
cord-015021-pol2qm74	3053	3	no	no	DT
cord-015021-pol2qm74	3053	4	interference	interference	NN
cord-015021-pol2qm74	3053	5	of	of	IN
cord-015021-pol2qm74	3053	6	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3053	7	in	in	IN
cord-015021-pol2qm74	3053	8	the	the	DT
cord-015021-pol2qm74	3053	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	3053	10	ELISA	ELISA	NNP
cord-015021-pol2qm74	3053	11	or	or	CC
cord-015021-pol2qm74	3053	12	bio	bio	NN
cord-015021-pol2qm74	3053	13	-	-	HYPH
cord-015021-pol2qm74	3053	14	assay	assay	NN
cord-015021-pol2qm74	3053	15	and	and	CC
cord-015021-pol2qm74	3053	16	no	no	DT
cord-015021-pol2qm74	3053	17	interference	interference	NN
cord-015021-pol2qm74	3053	18	of	of	IN
cord-015021-pol2qm74	3053	19	1L-6	1l-6	CD
cord-015021-pol2qm74	3053	20	in	in	IN
cord-015021-pol2qm74	3053	21	the	the	DT
cord-015021-pol2qm74	3053	22	sIL-6R	sil-6r	NN
cord-015021-pol2qm74	3053	23	ELISA	ELISA	NNP
cord-015021-pol2qm74	3053	24	.	.	.
cord-015021-pol2qm74	3054	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3054	2	:	:	:
cord-015021-pol2qm74	3055	1	In	in	IN
cord-015021-pol2qm74	3055	2	all	all	DT
cord-015021-pol2qm74	3055	3	investigated	investigate	VBN
cord-015021-pol2qm74	3055	4	biological	biological	JJ
cord-015021-pol2qm74	3055	5	fluids	fluid	NNS
cord-015021-pol2qm74	3055	6	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3055	7	can	can	MD
cord-015021-pol2qm74	3055	8	be	be	VB
cord-015021-pol2qm74	3055	9	found	find	VBN
cord-015021-pol2qm74	3055	10	.	.	.
cord-015021-pol2qm74	3056	1	These	these	DT
cord-015021-pol2qm74	3056	2	data	datum	NNS
cord-015021-pol2qm74	3056	3	provide	provide	VBP
cord-015021-pol2qm74	3056	4	baseline	baseline	JJ
cord-015021-pol2qm74	3056	5	values	value	NNS
cord-015021-pol2qm74	3056	6	for	for	IN
cord-015021-pol2qm74	3056	7	investigations	investigation	NNS
cord-015021-pol2qm74	3056	8	concerning	concern	VBG
cord-015021-pol2qm74	3056	9	pathological	pathological	JJ
cord-015021-pol2qm74	3056	10	situations	situation	NNS
cord-015021-pol2qm74	3056	11	.	.	.
cord-015021-pol2qm74	3057	1	Both	both	DT
cord-015021-pol2qm74	3057	2	ELISA	ELISA	NNP
cord-015021-pol2qm74	3057	3	's	's	POS
cord-015021-pol2qm74	3057	4	described	describe	VBN
cord-015021-pol2qm74	3057	5	are	be	VBP
cord-015021-pol2qm74	3057	6	useful	useful	JJ
cord-015021-pol2qm74	3057	7	tools	tool	NNS
cord-015021-pol2qm74	3057	8	to	to	TO
cord-015021-pol2qm74	3057	9	do	do	VB
cord-015021-pol2qm74	3057	10	these	these	DT
cord-015021-pol2qm74	3057	11	investigations	investigation	NNS
cord-015021-pol2qm74	3057	12	.	.	.
cord-015021-pol2qm74	3058	1	Trauma	trauma	NN
cord-015021-pol2qm74	3058	2	-	-	HYPH
cord-015021-pol2qm74	3058	3	associated	associate	VBN
cord-015021-pol2qm74	3058	4	immune	immune	JJ
cord-015021-pol2qm74	3058	5	aberrations	aberration	NNS
cord-015021-pol2qm74	3058	6	coincide	coincide	VBP
cord-015021-pol2qm74	3058	7	with	with	IN
cord-015021-pol2qm74	3058	8	augmented	augment	VBN
cord-015021-pol2qm74	3058	9	release	release	NN
cord-015021-pol2qm74	3058	10	of	of	IN
cord-015021-pol2qm74	3058	11	immunoregulatory	immunoregulatory	JJ
cord-015021-pol2qm74	3058	12	and	and	CC
cord-015021-pol2qm74	3058	13	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3058	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	3058	15	.	.	.
cord-015021-pol2qm74	3059	1	The	the	DT
cord-015021-pol2qm74	3059	2	present	present	JJ
cord-015021-pol2qm74	3059	3	study	study	NN
cord-015021-pol2qm74	3059	4	examines	examine	VBZ
cord-015021-pol2qm74	3059	5	the	the	DT
cord-015021-pol2qm74	3059	6	effect	effect	NN
cord-015021-pol2qm74	3059	7	of	of	IN
cord-015021-pol2qm74	3059	8	thermal	thermal	JJ
cord-015021-pol2qm74	3059	9	trauma	trauma	NN
cord-015021-pol2qm74	3059	10	on	on	IN
cord-015021-pol2qm74	3059	11	the	the	DT
cord-015021-pol2qm74	3059	12	capacity	capacity	NN
cord-015021-pol2qm74	3059	13	for	for	IN
cord-015021-pol2qm74	3059	14	specific	specific	JJ
cord-015021-pol2qm74	3059	15	(	(	-LRB-
cord-015021-pol2qm74	3059	16	receptormediated	receptormediated	JJ
cord-015021-pol2qm74	3059	17	)	)	-RRB-
cord-015021-pol2qm74	3059	18	response	response	NN
cord-015021-pol2qm74	3059	19	of	of	IN
cord-015021-pol2qm74	3059	20	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	3059	21	cells	cell	NNS
cord-015021-pol2qm74	3059	22	to	to	IN
cord-015021-pol2qm74	3059	23	interleukin	interleukin	NN
cord-015021-pol2qm74	3059	24	1	1	CD
cord-015021-pol2qm74	3059	25	(	(	-LRB-
cord-015021-pol2qm74	3059	26	IL	IL	NNP
cord-015021-pol2qm74	3059	27	1	1	CD
cord-015021-pol2qm74	3059	28	)	)	-RRB-
cord-015021-pol2qm74	3059	29	and	and	CC
cord-015021-pol2qm74	3059	30	to	to	TO
cord-015021-pol2qm74	3059	31	turnout	turnout	VB
cord-015021-pol2qm74	3059	32	necrosis	necrosis	NN
cord-015021-pol2qm74	3059	33	factor	factor	NN
cord-015021-pol2qm74	3060	1	~x	~x	NNP
cord-015021-pol2qm74	3061	1	(	(	-LRB-
cord-015021-pol2qm74	3061	2	TNFc0	TNFc0	NNP
cord-015021-pol2qm74	3061	3	.	.	.
cord-015021-pol2qm74	3061	4	Methods	method	NNS
cord-015021-pol2qm74	3061	5	.	.	.
cord-015021-pol2qm74	3062	1	Bum	bum	NN
cord-015021-pol2qm74	3062	2	patients	patient	NNS
cord-015021-pol2qm74	3062	3	(	(	-LRB-
cord-015021-pol2qm74	3062	4	N=24	N=24	NNP
cord-015021-pol2qm74	3062	5	,	,	,
cord-015021-pol2qm74	3062	6	25->75	25->75	CD
cord-015021-pol2qm74	3062	7	%	%	NN
cord-015021-pol2qm74	3062	8	total	total	JJ
cord-015021-pol2qm74	3062	9	body	body	NN
cord-015021-pol2qm74	3062	10	surface	surface	NN
cord-015021-pol2qm74	3062	11	area	area	NN
cord-015021-pol2qm74	3062	12	)	)	-RRB-
cord-015021-pol2qm74	3062	13	were	be	VBD
cord-015021-pol2qm74	3062	14	studied	study	VBN
cord-015021-pol2qm74	3062	15	weekly	weekly	RB
cord-015021-pol2qm74	3062	16	up	up	IN
cord-015021-pol2qm74	3062	17	to	to	TO
cord-015021-pol2qm74	3062	18	42	42	CD
cord-015021-pol2qm74	3062	19	days	day	NNS
cord-015021-pol2qm74	3062	20	post	post	NN
cord-015021-pol2qm74	3062	21	-	-	JJ
cord-015021-pol2qm74	3062	22	injury	injury	NN
cord-015021-pol2qm74	3062	23	.	.	.
cord-015021-pol2qm74	3063	1	The	the	DT
cord-015021-pol2qm74	3063	2	Limulus	Limulus	NNP
cord-015021-pol2qm74	3063	3	Amoebocyte	Amoebocyte	NNP
cord-015021-pol2qm74	3063	4	Lysate	Lysate	NNP
cord-015021-pol2qm74	3063	5	(	(	-LRB-
cord-015021-pol2qm74	3063	6	LAL	LAL	NNP
cord-015021-pol2qm74	3063	7	)	)	-RRB-
cord-015021-pol2qm74	3063	8	test	test	NN
cord-015021-pol2qm74	3063	9	was	be	VBD
cord-015021-pol2qm74	3063	10	used	use	VBN
cord-015021-pol2qm74	3063	11	to	to	TO
cord-015021-pol2qm74	3063	12	measure	measure	VB
cord-015021-pol2qm74	3063	13	plasma	plasma	NN
cord-015021-pol2qm74	3063	14	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3063	15	levels	level	NNS
cord-015021-pol2qm74	3063	16	.	.	.
cord-015021-pol2qm74	3064	1	The	the	DT
cord-015021-pol2qm74	3064	2	percentage	percentage	NN
cord-015021-pol2qm74	3064	3	of	of	IN
cord-015021-pol2qm74	3064	4	IL	IL	NNP
cord-015021-pol2qm74	3064	5	1~-and	1~-and	CD
cord-015021-pol2qm74	3064	6	TNFcz	TNFcz	NNP
cord-015021-pol2qm74	3064	7	-	-	HYPH
cord-015021-pol2qm74	3064	8	binding	bind	VBG
cord-015021-pol2qm74	3064	9	T(CD	T(CD	NNP
cord-015021-pol2qm74	3064	10	5	5	CD
cord-015021-pol2qm74	3064	11	)	)	-RRB-
cord-015021-pol2qm74	3064	12	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	3064	13	was	be	VBD
cord-015021-pol2qm74	3064	14	assessed	assess	VBN
cord-015021-pol2qm74	3064	15	by	by	IN
cord-015021-pol2qm74	3064	16	flow	flow	NN
cord-015021-pol2qm74	3064	17	cytometry	cytometry	NN
cord-015021-pol2qm74	3064	18	analysis	analysis	NN
cord-015021-pol2qm74	3064	19	.	.	.
cord-015021-pol2qm74	3065	1	Levels	level	NNS
cord-015021-pol2qm74	3065	2	of	of	IN
cord-015021-pol2qm74	3065	3	IL	IL	NNP
cord-015021-pol2qm74	3065	4	1	1	CD
cord-015021-pol2qm74	3065	5	receptor	receptor	NN
cord-015021-pol2qm74	3065	6	antagonist	antagonist	NN
cord-015021-pol2qm74	3065	7	(	(	-LRB-
cord-015021-pol2qm74	3065	8	IL	IL	NNP
cord-015021-pol2qm74	3065	9	lra	lra	NNP
cord-015021-pol2qm74	3065	10	)	)	-RRB-
cord-015021-pol2qm74	3065	11	in	in	IN
cord-015021-pol2qm74	3065	12	patients	patient	NNS
cord-015021-pol2qm74	3065	13	'	'	POS
cord-015021-pol2qm74	3065	14	plasma	plasma	NN
cord-015021-pol2qm74	3065	15	and	and	CC
cord-015021-pol2qm74	3065	16	cultures	culture	NNS
cord-015021-pol2qm74	3065	17	of	of	IN
cord-015021-pol2qm74	3065	18	peripheral	peripheral	JJ
cord-015021-pol2qm74	3065	19	blood	blood	NN
cord-015021-pol2qm74	3065	20	ceils	ceil	NNS
cord-015021-pol2qm74	3065	21	(	(	-LRB-
cord-015021-pol2qm74	3065	22	PBC	PBC	NNP
cord-015021-pol2qm74	3065	23	)	)	-RRB-
cord-015021-pol2qm74	3065	24	were	be	VBD
cord-015021-pol2qm74	3065	25	determined	determine	VBN
cord-015021-pol2qm74	3065	26	by	by	IN
cord-015021-pol2qm74	3065	27	immunoassay	immunoassay	NN
cord-015021-pol2qm74	3065	28	.	.	.
cord-015021-pol2qm74	3066	1	Results	result	NNS
cord-015021-pol2qm74	3066	2	.	.	.
cord-015021-pol2qm74	3067	1	Plasma	plasma	NN
cord-015021-pol2qm74	3067	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3067	3	concentrations	concentration	NNS
cord-015021-pol2qm74	3067	4	were	be	VBD
cord-015021-pol2qm74	3067	5	significantly	significantly	RB
cord-015021-pol2qm74	3067	6	(	(	-LRB-
cord-015021-pol2qm74	3067	7	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	3067	8	)	)	-RRB-
cord-015021-pol2qm74	3067	9	increased	increase	VBD
cord-015021-pol2qm74	3067	10	up	up	RB
cord-015021-pol2qm74	3067	11	to	to	TO
cord-015021-pol2qm74	3067	12	3	3	CD
cord-015021-pol2qm74	3067	13	weeks	week	NNS
cord-015021-pol2qm74	3067	14	post	post	JJ
cord-015021-pol2qm74	3067	15	-	-	JJ
cord-015021-pol2qm74	3067	16	bum	bum	JJ
cord-015021-pol2qm74	3067	17	(	(	-LRB-
cord-015021-pol2qm74	3067	18	means	mean	VBZ
cord-015021-pol2qm74	3067	19	3.5	3.5	CD
cord-015021-pol2qm74	3067	20	+	+	SYM
cord-015021-pol2qm74	3067	21	1	1	CD
cord-015021-pol2qm74	3067	22	in	in	IN
cord-015021-pol2qm74	3067	23	non	non	JJ
cord-015021-pol2qm74	3067	24	-	-	JJ
cord-015021-pol2qm74	3067	25	surviving	surviving	JJ
cord-015021-pol2qm74	3067	26	and	and	CC
cord-015021-pol2qm74	3067	27	2.6	2.6	CD
cord-015021-pol2qm74	3067	28	+	+	SYM
cord-015021-pol2qm74	3067	29	0.6	0.6	CD
cord-015021-pol2qm74	3067	30	U	u	NN
cord-015021-pol2qm74	3067	31	/	/	SYM
cord-015021-pol2qm74	3067	32	ml	ml	XX
cord-015021-pol2qm74	3067	33	in	in	IN
cord-015021-pol2qm74	3067	34	surviving	survive	VBG
cord-015021-pol2qm74	3067	35	patients	patient	NNS
cord-015021-pol2qm74	3067	36	vs	vs	IN
cord-015021-pol2qm74	3067	37	<	<	XX
cord-015021-pol2qm74	3067	38	1U	1U	NNP
cord-015021-pol2qm74	3067	39	/	/	SYM
cord-015021-pol2qm74	3067	40	ml	ml	XX
cord-015021-pol2qm74	3067	41	in	in	IN
cord-015021-pol2qm74	3067	42	the	the	DT
cord-015021-pol2qm74	3067	43	control	control	NN
cord-015021-pol2qm74	3067	44	)	)	-RRB-
cord-015021-pol2qm74	3067	45	.	.	.
cord-015021-pol2qm74	3068	1	Within	within	IN
cord-015021-pol2qm74	3068	2	2	2	CD
cord-015021-pol2qm74	3068	3	weeks	week	NNS
cord-015021-pol2qm74	3068	4	of	of	IN
cord-015021-pol2qm74	3068	5	bum	bum	NN
cord-015021-pol2qm74	3068	6	,	,	,
cord-015021-pol2qm74	3068	7	the	the	DT
cord-015021-pol2qm74	3068	8	percentage	percentage	NN
cord-015021-pol2qm74	3068	9	ofT	oft	VBP
cord-015021-pol2qm74	3068	10	ceils	ceil	NNS
cord-015021-pol2qm74	3068	11	expressing	express	VBG
cord-015021-pol2qm74	3068	12	receptors	receptor	NNS
cord-015021-pol2qm74	3068	13	for	for	IN
cord-015021-pol2qm74	3068	14	TNFa	TNFa	NNS
cord-015021-pol2qm74	3068	15	and	and	CC
cord-015021-pol2qm74	3068	16	IL	IL	NNP
cord-015021-pol2qm74	3068	17	1[~	1[~	NNP
cord-015021-pol2qm74	3068	18	constitutively	constitutively	RB
cord-015021-pol2qm74	3068	19	was	be	VBD
cord-015021-pol2qm74	3068	20	elevated	elevate	VBN
cord-015021-pol2qm74	3068	21	(	(	-LRB-
cord-015021-pol2qm74	3068	22	by	by	IN
cord-015021-pol2qm74	3068	23	10	10	CD
cord-015021-pol2qm74	3068	24	-	-	SYM
cord-015021-pol2qm74	3068	25	15	15	CD
cord-015021-pol2qm74	3068	26	fold	fold	NN
cord-015021-pol2qm74	3068	27	)	)	-RRB-
cord-015021-pol2qm74	3068	28	.	.	.
cord-015021-pol2qm74	3069	1	In	in	IN
cord-015021-pol2qm74	3069	2	contrast	contrast	NN
cord-015021-pol2qm74	3069	3	,	,	,
cord-015021-pol2qm74	3069	4	the	the	DT
cord-015021-pol2qm74	3069	5	capacity	capacity	NN
cord-015021-pol2qm74	3069	6	for	for	IN
cord-015021-pol2qm74	3069	7	de	de	NNP
cord-015021-pol2qm74	3069	8	novo	novo	NNP
cord-015021-pol2qm74	3069	9	receptor	receptor	NN
cord-015021-pol2qm74	3069	10	expression	expression	NN
cord-015021-pol2qm74	3069	11	by	by	IN
cord-015021-pol2qm74	3069	12	activated	activate	VBN
cord-015021-pol2qm74	3069	13	PBC	PBC	NNP
cord-015021-pol2qm74	3069	14	was	be	VBD
cord-015021-pol2qm74	3069	15	reduced	reduce	VBN
cord-015021-pol2qm74	3069	16	.	.	.
cord-015021-pol2qm74	3070	1	Serum	serum	NN
cord-015021-pol2qm74	3070	2	levels	level	NNS
cord-015021-pol2qm74	3070	3	of	of	IN
cord-015021-pol2qm74	3070	4	IL	IL	NNP
cord-015021-pol2qm74	3070	5	Ira	Ira	NNP
cord-015021-pol2qm74	3070	6	were	be	VBD
cord-015021-pol2qm74	3070	7	significantly	significantly	RB
cord-015021-pol2qm74	3070	8	increased	increase	VBN
cord-015021-pol2qm74	3070	9	(	(	-LRB-
cord-015021-pol2qm74	3070	10	range	range	VB
cord-015021-pol2qm74	3070	11	2.5	2.5	CD
cord-015021-pol2qm74	3070	12	-	-	HYPH
cord-015021-pol2qm74	3070	13	40x10	40x10	CD
cord-015021-pol2qm74	3070	14	J	J	NNP
cord-015021-pol2qm74	3070	15	pg	pg	NNP
cord-015021-pol2qm74	3070	16	/	/	SYM
cord-015021-pol2qm74	3070	17	ml	ml	XX
cord-015021-pol2qm74	3070	18	vs	vs	IN
cord-015021-pol2qm74	3070	19	<	<	XX
cord-015021-pol2qm74	3070	20	0.2x10	0.2x10	CD
cord-015021-pol2qm74	3070	21	J	J	NNP
cord-015021-pol2qm74	3070	22	pg	pg	NNP
cord-015021-pol2qm74	3070	23	/	/	SYM
cord-015021-pol2qm74	3070	24	ml	ml	XX
cord-015021-pol2qm74	3070	25	in	in	IN
cord-015021-pol2qm74	3070	26	the	the	DT
cord-015021-pol2qm74	3070	27	control	control	NN
cord-015021-pol2qm74	3070	28	)	)	-RRB-
cord-015021-pol2qm74	3070	29	.	.	.
cord-015021-pol2qm74	3071	1	In	in	IN
cord-015021-pol2qm74	3071	2	all	all	DT
cord-015021-pol2qm74	3071	3	patients	patient	NNS
cord-015021-pol2qm74	3071	4	,	,	,
cord-015021-pol2qm74	3071	5	high	high	JJ
cord-015021-pol2qm74	3071	6	concentrations	concentration	NNS
cord-015021-pol2qm74	3071	7	of	of	IN
cord-015021-pol2qm74	3071	8	IL	IL	NNP
cord-015021-pol2qm74	3071	9	lm	lm	NNP
cord-015021-pol2qm74	3071	10	were	be	VBD
cord-015021-pol2qm74	3071	11	released	release	VBN
cord-015021-pol2qm74	3071	12	spontaneously	spontaneously	RB
cord-015021-pol2qm74	3071	13	in	in	IN
cord-015021-pol2qm74	3071	14	unstimulated	unstimulated	JJ
cord-015021-pol2qm74	3071	15	cultures	culture	NNS
cord-015021-pol2qm74	3071	16	of	of	IN
cord-015021-pol2qm74	3071	17	adherent	adherent	JJ
cord-015021-pol2qm74	3071	18	ceils	ceil	NNS
cord-015021-pol2qm74	3071	19	(	(	-LRB-
cord-015021-pol2qm74	3071	20	range	range	VBP
cord-015021-pol2qm74	3071	21	20	20	CD
cord-015021-pol2qm74	3071	22	-	-	SYM
cord-015021-pol2qm74	3071	23	30x10	30x10	CD
cord-015021-pol2qm74	3071	24	-3	-3	NNP
cord-015021-pol2qm74	3071	25	pg	pg	NNP
cord-015021-pol2qm74	3071	26	/	/	SYM
cord-015021-pol2qm74	3071	27	ml	ml	NN
cord-015021-pol2qm74	3071	28	vs	vs	IN
cord-015021-pol2qm74	3071	29	4	4	CD
cord-015021-pol2qm74	3071	30	-	-	SYM
cord-015021-pol2qm74	3071	31	8x10J	8x10j	CD
cord-015021-pol2qm74	3071	32	pg	pg	NNP
cord-015021-pol2qm74	3071	33	/	/	SYM
cord-015021-pol2qm74	3071	34	ml	ml	XX
cord-015021-pol2qm74	3071	35	in	in	IN
cord-015021-pol2qm74	3071	36	the	the	DT
cord-015021-pol2qm74	3071	37	control	control	NN
cord-015021-pol2qm74	3071	38	)	)	-RRB-
cord-015021-pol2qm74	3071	39	.	.	.
cord-015021-pol2qm74	3072	1	However	however	RB
cord-015021-pol2qm74	3072	2	,	,	,
cord-015021-pol2qm74	3072	3	its	-PRON-	PRP$
cord-015021-pol2qm74	3072	4	secretion	secretion	NN
cord-015021-pol2qm74	3072	5	was	be	VBD
cord-015021-pol2qm74	3072	6	decreased	decrease	VBN
cord-015021-pol2qm74	3072	7	in	in	IN
cord-015021-pol2qm74	3072	8	LPS	LPS	NNP
cord-015021-pol2qm74	3072	9	-	-	HYPH
cord-015021-pol2qm74	3072	10	stimulated	stimulate	VBN
cord-015021-pol2qm74	3072	11	parallel	parallel	JJ
cord-015021-pol2qm74	3072	12	preparations	preparation	NNS
cord-015021-pol2qm74	3072	13	.	.	.
cord-015021-pol2qm74	3073	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3073	2	.	.	.
cord-015021-pol2qm74	3074	1	In	in	IN
cord-015021-pol2qm74	3074	2	the	the	DT
cord-015021-pol2qm74	3074	3	bum	bum	NN
cord-015021-pol2qm74	3074	4	patient	patient	NN
cord-015021-pol2qm74	3074	5	,	,	,
cord-015021-pol2qm74	3074	6	susceptibility	susceptibility	NN
cord-015021-pol2qm74	3074	7	to	to	IN
cord-015021-pol2qm74	3074	8	the	the	DT
cord-015021-pol2qm74	3074	9	immunoregulatory	immunoregulatory	JJ
cord-015021-pol2qm74	3074	10	effect	effect	NN
cord-015021-pol2qm74	3074	11	of	of	IN
cord-015021-pol2qm74	3074	12	TNFcz	TNFcz	NNP
cord-015021-pol2qm74	3074	13	and	and	CC
cord-015021-pol2qm74	3074	14	tL	tL	NNP
cord-015021-pol2qm74	3074	15	1~	1~	CD
cord-015021-pol2qm74	3074	16	may	may	MD
cord-015021-pol2qm74	3074	17	be	be	VB
cord-015021-pol2qm74	3074	18	modulated	modulate	VBN
cord-015021-pol2qm74	3074	19	by	by	IN
cord-015021-pol2qm74	3074	20	infection	infection	NN
cord-015021-pol2qm74	3074	21	-	-	HYPH
cord-015021-pol2qm74	3074	22	related	relate	VBN
cord-015021-pol2qm74	3074	23	products	product	NNS
cord-015021-pol2qm74	3074	24	.	.	.
cord-015021-pol2qm74	3075	1	Alterations	alteration	NNS
cord-015021-pol2qm74	3075	2	in	in	IN
cord-015021-pol2qm74	3075	3	the	the	DT
cord-015021-pol2qm74	3075	4	capacity	capacity	NN
cord-015021-pol2qm74	3075	5	for	for	IN
cord-015021-pol2qm74	3075	6	receptor	receptor	NN
cord-015021-pol2qm74	3075	7	expression	expression	NN
cord-015021-pol2qm74	3075	8	and	and	CC
cord-015021-pol2qm74	3075	9	secretion	secretion	NN
cord-015021-pol2qm74	3075	10	of	of	IN
cord-015021-pol2qm74	3075	11	1L	1l	CD
cord-015021-pol2qm74	3076	1	lra	lra	NNP
cord-015021-pol2qm74	3076	2	may	may	MD
cord-015021-pol2qm74	3076	3	affect	affect	VB
cord-015021-pol2qm74	3076	4	IL	IL	NNP
cord-015021-pol2qm74	3076	5	1-regulated	1-regulated	CD
cord-015021-pol2qm74	3076	6	biological	biological	JJ
cord-015021-pol2qm74	3076	7	responses	response	NNS
cord-015021-pol2qm74	3076	8	including	include	VBG
cord-015021-pol2qm74	3076	9	specific	specific	JJ
cord-015021-pol2qm74	3076	10	immune	immune	JJ
cord-015021-pol2qm74	3076	11	reactions	reaction	NNS
cord-015021-pol2qm74	3076	12	.	.	.
cord-015021-pol2qm74	3077	1	While	while	IN
cord-015021-pol2qm74	3077	2	studies	study	NNS
cord-015021-pol2qm74	3077	3	suggest	suggest	VBP
cord-015021-pol2qm74	3077	4	that	that	IN
cord-015021-pol2qm74	3077	5	IL-10	IL-10	NNP
cord-015021-pol2qm74	3077	6	is	be	VBZ
cord-015021-pol2qm74	3077	7	an	an	DT
cord-015021-pol2qm74	3077	8	important	important	JJ
cord-015021-pol2qm74	3077	9	lymphokine	lymphokine	NN
cord-015021-pol2qm74	3077	10	involved	involve	VBN
cord-015021-pol2qm74	3077	11	in	in	IN
cord-015021-pol2qm74	3077	12	cell	cell	NN
cord-015021-pol2qm74	3077	13	-	-	HYPH
cord-015021-pol2qm74	3077	14	mediated	mediate	VBN
cord-015021-pol2qm74	3077	15	immunity	immunity	NN
cord-015021-pol2qm74	3077	16	,	,	,
cord-015021-pol2qm74	3077	17	little	little	JJ
cord-015021-pol2qm74	3077	18	is	be	VBZ
cord-015021-pol2qm74	3077	19	known	know	VBN
cord-015021-pol2qm74	3077	20	about	about	IN
cord-015021-pol2qm74	3077	21	this	this	DT
cord-015021-pol2qm74	3077	22	mediator	mediator	NN
cord-015021-pol2qm74	3077	23	's	's	POS
cord-015021-pol2qm74	3077	24	role	role	NN
cord-015021-pol2qm74	3077	25	in	in	IN
cord-015021-pol2qm74	3077	26	HEM	HEM	NNP
cord-015021-pol2qm74	3077	27	-	-	HYPH
cord-015021-pol2qm74	3077	28	induced	induce	VBN
cord-015021-pol2qm74	3077	29	immunesuppression	immunesuppression	NN
cord-015021-pol2qm74	3077	30	.	.	.
cord-015021-pol2qm74	3078	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3078	2	aims	aim	NNS
cord-015021-pol2qm74	3078	3	,	,	,
cord-015021-pol2qm74	3078	4	therefore	therefore	RB
cord-015021-pol2qm74	3078	5	,	,	,
cord-015021-pol2qm74	3078	6	were	be	VBD
cord-015021-pol2qm74	3078	7	to	to	TO
cord-015021-pol2qm74	3078	8	determine	determine	VB
cord-015021-pol2qm74	3078	9	:	:	:
cord-015021-pol2qm74	3079	1	I	-PRON-	PRP
cord-015021-pol2qm74	3079	2	)	)	-RRB-
cord-015021-pol2qm74	3079	3	if	if	IN
cord-015021-pol2qm74	3079	4	IL-10	IL-10	NNP
cord-015021-pol2qm74	3079	5	contributes	contribute	VBZ
cord-015021-pol2qm74	3079	6	to	to	IN
cord-015021-pol2qm74	3079	7	depressed	depressed	JJ
cord-015021-pol2qm74	3079	8	T	t	NN
cord-015021-pol2qm74	3079	9	-	-	HYPH
cord-015021-pol2qm74	3079	10	cell	cell	NN
cord-015021-pol2qm74	3079	11	responses	response	NNS
cord-015021-pol2qm74	3079	12	seen	see	VBN
cord-015021-pol2qm74	3079	13	following	follow	VBG
cord-015021-pol2qm74	3079	14	HEM	HEM	NNP
cord-015021-pol2qm74	3079	15	;	;	:
cord-015021-pol2qm74	3079	16	and	and	CC
cord-015021-pol2qm74	3079	17	2	2	LS
cord-015021-pol2qm74	3079	18	)	)	-RRB-
cord-015021-pol2qm74	3080	1	how	how	WRB
cord-015021-pol2qm74	3080	2	other	other	JJ
cord-015021-pol2qm74	3080	3	agents	agent	NNS
cord-015021-pol2qm74	3080	4	,	,	,
cord-015021-pol2qm74	3080	5	known	know	VBN
cord-015021-pol2qm74	3080	6	to	to	TO
cord-015021-pol2qm74	3080	7	play	play	VB
cord-015021-pol2qm74	3080	8	a	a	DT
cord-015021-pol2qm74	3080	9	role	role	NN
cord-015021-pol2qm74	3080	10	in	in	IN
cord-015021-pol2qm74	3080	11	HEM	HEM	NNP
cord-015021-pol2qm74	3080	12	,	,	,
cord-015021-pol2qm74	3080	13	effect	effect	NN
cord-015021-pol2qm74	3080	14	IL-10	IL-10	NNP
cord-015021-pol2qm74	3080	15	release	release	NN
cord-015021-pol2qm74	3080	16	.	.	.
cord-015021-pol2qm74	3081	1	To	to	TO
cord-015021-pol2qm74	3081	2	study	study	VB
cord-015021-pol2qm74	3081	3	this	this	DT
cord-015021-pol2qm74	3081	4	,	,	,
cord-015021-pol2qm74	3081	5	C3H	c3h	JJ
cord-015021-pol2qm74	3081	6	/	/	SYM
cord-015021-pol2qm74	3081	7	HeN	hen	JJ
cord-015021-pol2qm74	3081	8	mice	mouse	NNS
cord-015021-pol2qm74	3081	9	were	be	VBD
cord-015021-pol2qm74	3081	10	bled	bleed	VBN
cord-015021-pol2qm74	3081	11	to	to	IN
cord-015021-pol2qm74	3081	12	and	and	CC
cord-015021-pol2qm74	3081	13	maintained	maintain	VBD
cord-015021-pol2qm74	3081	14	at	at	IN
cord-015021-pol2qm74	3081	15	a	a	DT
cord-015021-pol2qm74	3081	16	MAP	map	NN
cord-015021-pol2qm74	3081	17	of	of	IN
cord-015021-pol2qm74	3081	18	35	35	CD
cord-015021-pol2qm74	3081	19	mmHg	mmHg	NNS
cord-015021-pol2qm74	3081	20	for	for	IN
cord-015021-pol2qm74	3081	21	1	1	CD
cord-015021-pol2qm74	3081	22	h	h	NN
cord-015021-pol2qm74	3081	23	and	and	CC
cord-015021-pol2qm74	3081	24	then	then	RB
cord-015021-pol2qm74	3081	25	adequately	adequately	RB
cord-015021-pol2qm74	3081	26	resuscitated	resuscitate	VBD
cord-015021-pol2qm74	3081	27	.	.	.
cord-015021-pol2qm74	3082	1	Mice	mouse	NNS
cord-015021-pol2qm74	3082	2	were	be	VBD
cord-015021-pol2qm74	3082	3	killed	kill	VBN
cord-015021-pol2qm74	3082	4	2	2	CD
cord-015021-pol2qm74	3082	5	h	h	NN
cord-015021-pol2qm74	3082	6	post	post	NN
cord-015021-pol2qm74	3082	7	-	-	JJ
cord-015021-pol2qm74	3082	8	HEM	HEM	NNP
cord-015021-pol2qm74	3082	9	to	to	TO
cord-015021-pol2qm74	3082	10	obtain	obtain	VB
cord-015021-pol2qm74	3082	11	splenic	splenic	JJ
cord-015021-pol2qm74	3082	12	T	t	NN
cord-015021-pol2qm74	3082	13	-	-	HYPH
cord-015021-pol2qm74	3082	14	cells	cell	NNS
cord-015021-pol2qm74	3082	15	(	(	-LRB-
cord-015021-pol2qm74	3082	16	nylon	nylon	NN
cord-015021-pol2qm74	3082	17	-	-	HYPH
cord-015021-pol2qm74	3082	18	wool	wool	NN
cord-015021-pol2qm74	3082	19	purified	purify	VBN
cord-015021-pol2qm74	3082	20	)	)	-RRB-
cord-015021-pol2qm74	3082	21	.	.	.
cord-015021-pol2qm74	3083	1	IL-10	IL-10	NNP
cord-015021-pol2qm74	3083	2	's	's	POS
cord-015021-pol2qm74	3083	3	immunosuppressant	immunosuppressant	JJ
cord-015021-pol2qm74	3083	4	role	role	NN
cord-015021-pol2qm74	3083	5	was	be	VBD
cord-015021-pol2qm74	3083	6	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3083	7	by	by	IN
cord-015021-pol2qm74	3083	8	the	the	DT
cord-015021-pol2qm74	3083	9	ability	ability	NN
cord-015021-pol2qm74	3083	10	of	of	IN
cord-015021-pol2qm74	3083	11	monoclenal	monoclenal	JJ
cord-015021-pol2qm74	3083	12	antibody	antibody	NN
cord-015021-pol2qm74	3083	13	(	(	-LRB-
cord-015021-pol2qm74	3083	14	Mab	Mab	NNP
cord-015021-pol2qm74	3083	15	)	)	-RRB-
cord-015021-pol2qm74	3083	16	to	to	IN
cord-015021-pol2qm74	3083	17	IL-10	IL-10	NNP
cord-015021-pol2qm74	3083	18	to	to	TO
cord-015021-pol2qm74	3083	19	markedly	markedly	RB
cord-015021-pol2qm74	3083	20	improve	improve	VB
cord-015021-pol2qm74	3083	21	the	the	DT
cord-015021-pol2qm74	3083	22	T	t	NN
cord-015021-pol2qm74	3083	23	-	-	HYPH
cord-015021-pol2qm74	3083	24	cell	cell	NN
cord-015021-pol2qm74	3083	25	proliferative	proliferative	JJ
cord-015021-pol2qm74	3083	26	response	response	NN
cord-015021-pol2qm74	3083	27	[	[	-LRB-
cord-015021-pol2qm74	3083	28	2.5	2.5	CD
cord-015021-pol2qm74	3083	29	#	#	NN
cord-015021-pol2qm74	3083	30	g	g	NN
cord-015021-pol2qm74	3084	1	The	the	DT
cord-015021-pol2qm74	3084	2	marked	marked	JJ
cord-015021-pol2qm74	3084	3	increase	increase	NN
cord-015021-pol2qm74	3084	4	in	in	IN
cord-015021-pol2qm74	3084	5	capacity	capacity	NN
cord-015021-pol2qm74	3084	6	of	of	IN
cord-015021-pol2qm74	3084	7	T	t	NN
cord-015021-pol2qm74	3084	8	-	-	HYPH
cord-015021-pol2qm74	3084	9	cells	cell	NNS
cord-015021-pol2qm74	3084	10	from	from	IN
cord-015021-pol2qm74	3084	11	HEM	HEM	NNP
cord-015021-pol2qm74	3084	12	mice	mouse	NNS
cord-015021-pol2qm74	3084	13	to	to	TO
cord-015021-pol2qm74	3084	14	produce	produce	VB
cord-015021-pol2qm74	3084	15	IL-10	IL-10	NNP
cord-015021-pol2qm74	3084	16	was	be	VBD
cord-015021-pol2qm74	3084	17	significantly	significantly	RB
cord-015021-pol2qm74	3084	18	reduced	reduce	VBN
cord-015021-pol2qm74	3084	19	by	by	IN
cord-015021-pol2qm74	3084	20	treatment	treatment	NN
cord-015021-pol2qm74	3084	21	with	with	IN
cord-015021-pol2qm74	3084	22	either	either	CC
cord-015021-pol2qm74	3084	23	IBU	IBU	NNP
cord-015021-pol2qm74	3084	24	or	or	CC
cord-015021-pol2qm74	3084	25	Mabs	Mabs	NNP
cord-015021-pol2qm74	3084	26	.	.	.
cord-015021-pol2qm74	3085	1	Since	since	IN
cord-015021-pol2qm74	3085	2	IBU	IBU	NNP
cord-015021-pol2qm74	3085	3	,	,	,
cord-015021-pol2qm74	3085	4	TGF-~	TGF-~	NNP
cord-015021-pol2qm74	3085	5	,	,	,
cord-015021-pol2qm74	3085	6	as	as	RB
cord-015021-pol2qm74	3085	7	well	well	RB
cord-015021-pol2qm74	3085	8	as	as	IN
cord-015021-pol2qm74	3085	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	3085	10	are	be	VBP
cord-015021-pol2qm74	3085	11	all	all	DT
cord-015021-pol2qm74	3085	12	reported	report	VBN
cord-015021-pol2qm74	3085	13	to	to	IN
cord-015021-pol2qm74	3085	14	directly	directly	RB
cord-015021-pol2qm74	3085	15	/	/	SYM
cord-015021-pol2qm74	3085	16	indirectly	indirectly	RB
cord-015021-pol2qm74	3085	17	influence	influence	VBP
cord-015021-pol2qm74	3085	18	prostanoid	prostanoid	NNP
cord-015021-pol2qm74	3085	19	synthesis	synthesis	NN
cord-015021-pol2qm74	3085	20	,	,	,
cord-015021-pol2qm74	3085	21	this	this	DT
cord-015021-pol2qm74	3085	22	implies	imply	VBZ
cord-015021-pol2qm74	3085	23	that	that	IN
cord-015021-pol2qm74	3085	24	eicosanoids	eicosanoid	NNS
cord-015021-pol2qm74	3085	25	play	play	VBP
cord-015021-pol2qm74	3085	26	a	a	DT
cord-015021-pol2qm74	3085	27	major	major	JJ
cord-015021-pol2qm74	3085	28	role	role	NN
cord-015021-pol2qm74	3085	29	in	in	IN
cord-015021-pol2qm74	3085	30	inducing	induce	VBG
cord-015021-pol2qm74	3085	31	IL-10	IL-10	NNP
cord-015021-pol2qm74	3085	32	release	release	NN
cord-015021-pol2qm74	3085	33	by	by	IN
cord-015021-pol2qm74	3085	34	T	T	NNP
cord-015021-pol2qm74	3085	35	-	-	HYPH
cord-015021-pol2qm74	3085	36	cells	cell	NNS
cord-015021-pol2qm74	3085	37	following	follow	VBG
cord-015021-pol2qm74	3085	38	HEM	HEM	NNP
cord-015021-pol2qm74	3085	39	which	which	WDT
cord-015021-pol2qm74	3085	40	depresses	depress	VBZ
cord-015021-pol2qm74	3085	41	T	t	NN
cord-015021-pol2qm74	3085	42	-	-	HYPH
cord-015021-pol2qm74	3085	43	cell	cell	NN
cord-015021-pol2qm74	3085	44	function	function	NN
cord-015021-pol2qm74	3085	45	.	.	.
cord-015021-pol2qm74	3086	1	The	the	DT
cord-015021-pol2qm74	3086	2	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3086	3	underlying	underlie	VBG
cord-015021-pol2qm74	3086	4	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	3086	5	induced	induce	VBN
cord-015021-pol2qm74	3086	6	by	by	IN
cord-015021-pol2qm74	3086	7	thermal	thermal	JJ
cord-015021-pol2qm74	3086	8	injury	injury	NN
cord-015021-pol2qm74	3086	9	and	and	CC
cord-015021-pol2qm74	3086	10	alcohol	alcohol	NN
cord-015021-pol2qm74	3086	11	ingestion	ingestion	NN
cord-015021-pol2qm74	3086	12	are	be	VBP
cord-015021-pol2qm74	3086	13	in	in	IN
cord-015021-pol2qm74	3086	14	part	part	NN
cord-015021-pol2qm74	3086	15	due	due	IN
cord-015021-pol2qm74	3086	16	to	to	IN
cord-015021-pol2qm74	3086	17	cytokine	cytokine	JJ
cord-015021-pol2qm74	3086	18	dysregulatinn	dysregulatinn	NN
cord-015021-pol2qm74	3086	19	.	.	.
cord-015021-pol2qm74	3087	1	IL-10	IL-10	NNP
cord-015021-pol2qm74	3088	1	down	down	RB
cord-015021-pol2qm74	3088	2	-	-	HYPH
cord-015021-pol2qm74	3088	3	regulates	regulate	VBZ
cord-015021-pol2qm74	3088	4	production	production	NN
cord-015021-pol2qm74	3088	5	of	of	IN
cord-015021-pol2qm74	3088	6	eytokines	eytokines	NNP
cord-015021-pol2qm74	3088	7	by	by	IN
cord-015021-pol2qm74	3088	8	maerophages	maerophage	NNS
cord-015021-pol2qm74	3088	9	and	and	CC
cord-015021-pol2qm74	3088	10	may	may	MD
cord-015021-pol2qm74	3088	11	be	be	VB
cord-015021-pol2qm74	3088	12	an	an	DT
cord-015021-pol2qm74	3088	13	important	important	JJ
cord-015021-pol2qm74	3088	14	regulator	regulator	NN
cord-015021-pol2qm74	3088	15	of	of	IN
cord-015021-pol2qm74	3088	16	the	the	DT
cord-015021-pol2qm74	3088	17	initiation	initiation	NN
cord-015021-pol2qm74	3088	18	of	of	IN
cord-015021-pol2qm74	3088	19	the	the	DT
cord-015021-pol2qm74	3088	20	immune	immune	JJ
cord-015021-pol2qm74	3088	21	response	response	NN
cord-015021-pol2qm74	3088	22	.	.	.
cord-015021-pol2qm74	3089	1	IL-10	IL-10	NNP
cord-015021-pol2qm74	3089	2	has	have	VBZ
cord-015021-pol2qm74	3089	3	also	also	RB
cord-015021-pol2qm74	3089	4	been	be	VBN
cord-015021-pol2qm74	3089	5	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3089	6	to	to	TO
cord-015021-pol2qm74	3089	7	inhibit	inhibit	VB
cord-015021-pol2qm74	3089	8	the	the	DT
cord-015021-pol2qm74	3089	9	production	production	NN
cord-015021-pol2qm74	3089	10	of	of	IN
cord-015021-pol2qm74	3089	11	NO	no	NN
cord-015021-pol2qm74	3089	12	by	by	IN
cord-015021-pol2qm74	3089	13	macrophages	macrophage	NNS
cord-015021-pol2qm74	3089	14	.	.	.
cord-015021-pol2qm74	3090	1	This	this	DT
cord-015021-pol2qm74	3090	2	study	study	NN
cord-015021-pol2qm74	3090	3	examined	examine	VBD
cord-015021-pol2qm74	3090	4	the	the	DT
cord-015021-pol2qm74	3090	5	alterations	alteration	NNS
cord-015021-pol2qm74	3090	6	in	in	IN
cord-015021-pol2qm74	3090	7	eytokine	eytokine	JJ
cord-015021-pol2qm74	3090	8	production	production	NN
cord-015021-pol2qm74	3090	9	and	and	CC
cord-015021-pol2qm74	3090	10	effect	effect	NN
cord-015021-pol2qm74	3090	11	of	of	IN
cord-015021-pol2qm74	3090	12	inhibition	inhibition	NN
cord-015021-pol2qm74	3090	13	of	of	IN
cord-015021-pol2qm74	3090	14	NO	no	DT
cord-015021-pol2qm74	3090	15	production	production	NN
cord-015021-pol2qm74	3090	16	on	on	IN
cord-015021-pol2qm74	3090	17	immunologic	immunologic	JJ
cord-015021-pol2qm74	3090	18	function	function	NN
cord-015021-pol2qm74	3090	19	in	in	IN
cord-015021-pol2qm74	3090	20	a	a	DT
cord-015021-pol2qm74	3090	21	routine	routine	JJ
cord-015021-pol2qm74	3090	22	thermal	thermal	JJ
cord-015021-pol2qm74	3090	23	injury	injury	NN
cord-015021-pol2qm74	3090	24	model	model	NN
cord-015021-pol2qm74	3090	25	.	.	.
cord-015021-pol2qm74	3091	1	METHODS	methods	NN
cord-015021-pol2qm74	3091	2	:	:	:
cord-015021-pol2qm74	3092	1	Balb	Balb	NNP
cord-015021-pol2qm74	3092	2	/	/	SYM
cord-015021-pol2qm74	3092	3	c	c	NN
cord-015021-pol2qm74	3092	4	mice	mouse	NNS
cord-015021-pol2qm74	3092	5	(	(	-LRB-
cord-015021-pol2qm74	3092	6	n=40	n=40	NNP
cord-015021-pol2qm74	3092	7	)	)	-RRB-
cord-015021-pol2qm74	3092	8	were	be	VBD
cord-015021-pol2qm74	3092	9	randomized	randomize	VBN
cord-015021-pol2qm74	3092	10	to	to	IN
cord-015021-pol2qm74	3092	11	4	4	CD
cord-015021-pol2qm74	3092	12	groups	group	NNS
cord-015021-pol2qm74	3092	13	:	:	:
cord-015021-pol2qm74	3093	1	Saline	Saline	NNP
cord-015021-pol2qm74	3093	2	-	-	HYPH
cord-015021-pol2qm74	3093	3	Sham(NS	Sham(NS	NNP
cord-015021-pol2qm74	3093	4	-	-	HYPH
cord-015021-pol2qm74	3093	5	Sham	Sham	NNP
cord-015021-pol2qm74	3093	6	)	)	-RRB-
cord-015021-pol2qm74	3093	7	,	,	,
cord-015021-pol2qm74	3093	8	Alcohol	Alcohol	NNP
cord-015021-pol2qm74	3093	9	-	-	HYPH
cord-015021-pol2qm74	3093	10	Sham(EtOH	Sham(EtOH	NNP
cord-015021-pol2qm74	3093	11	-	-	HYPH
cord-015021-pol2qm74	3093	12	Sham	Sham	NNP
cord-015021-pol2qm74	3093	13	)	)	-RRB-
cord-015021-pol2qm74	3093	14	,	,	,
cord-015021-pol2qm74	3093	15	NS	NS	NNP
cord-015021-pol2qm74	3093	16	-	-	HYPH
cord-015021-pol2qm74	3093	17	Bum	Bum	NNP
cord-015021-pol2qm74	3093	18	,	,	,
cord-015021-pol2qm74	3093	19	EtOH	EtOH	NNP
cord-015021-pol2qm74	3093	20	-	-	HYPH
cord-015021-pol2qm74	3093	21	Bum	Bum	NNP
cord-015021-pol2qm74	3093	22	.	.	.
cord-015021-pol2qm74	3094	1	Animals	animal	NNS
cord-015021-pol2qm74	3094	2	received	receive	VBD
cord-015021-pol2qm74	3094	3	20	20	CD
cord-015021-pol2qm74	3094	4	%	%	NN
cord-015021-pol2qm74	3094	5	EtOH	EtOH	NNP
cord-015021-pol2qm74	3094	6	or	or	CC
cord-015021-pol2qm74	3094	7	NS	NS	NNP
cord-015021-pol2qm74	3094	8	daily	daily	RB
cord-015021-pol2qm74	3094	9	for	for	IN
cord-015021-pol2qm74	3094	10	14	14	CD
cord-015021-pol2qm74	3094	11	days	day	NNS
cord-015021-pol2qm74	3094	12	by	by	IN
cord-015021-pol2qm74	3094	13	gavage	gavage	NN
cord-015021-pol2qm74	3094	14	.	.	.
cord-015021-pol2qm74	3095	1	A	a	DT
cord-015021-pol2qm74	3095	2	30	30	CD
cord-015021-pol2qm74	3095	3	%	%	NN
cord-015021-pol2qm74	3095	4	full	full	JJ
cord-015021-pol2qm74	3095	5	thickness	thickness	NN
cord-015021-pol2qm74	3095	6	bum	bum	NN
cord-015021-pol2qm74	3095	7	was	be	VBD
cord-015021-pol2qm74	3095	8	induced	induce	VBN
cord-015021-pol2qm74	3095	9	4	4	CD
cord-015021-pol2qm74	3095	10	hrs	hrs	NN
cord-015021-pol2qm74	3095	11	after	after	IN
cord-015021-pol2qm74	3095	12	the	the	DT
cord-015021-pol2qm74	3095	13	last	last	JJ
cord-015021-pol2qm74	3095	14	dose	dose	NN
cord-015021-pol2qm74	3095	15	of	of	IN
cord-015021-pol2qm74	3095	16	EtOH	EtOH	NNP
cord-015021-pol2qm74	3095	17	or	or	CC
cord-015021-pol2qm74	3095	18	NS	NS	NNP
cord-015021-pol2qm74	3095	19	.	.	.
cord-015021-pol2qm74	3096	1	Animals	animal	NNS
cord-015021-pol2qm74	3096	2	were	be	VBD
cord-015021-pol2qm74	3096	3	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	3096	4	,	,	,
cord-015021-pol2qm74	3096	5	then	then	RB
cord-015021-pol2qm74	3096	6	sacrificed	sacrifice	VBD
cord-015021-pol2qm74	3096	7	4	4	CD
cord-015021-pol2qm74	3096	8	days	day	NNS
cord-015021-pol2qm74	3096	9	post	post	VBP
cord-015021-pol2qm74	3096	10	bum	bum	NN
cord-015021-pol2qm74	3096	11	.	.	.
cord-015021-pol2qm74	3097	1	Splenic	splenic	JJ
cord-015021-pol2qm74	3097	2	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	3097	3	were	be	VBD
cord-015021-pol2qm74	3097	4	cultured	culture	VBN
cord-015021-pol2qm74	3097	5	for	for	IN
cord-015021-pol2qm74	3097	6	5	5	CD
cord-015021-pol2qm74	3097	7	days	day	NNS
cord-015021-pol2qm74	3097	8	with	with	IN
cord-015021-pol2qm74	3097	9	LPS	LPS	NNP
cord-015021-pol2qm74	3097	10	,	,	,
cord-015021-pol2qm74	3097	11	and	and	CC
cord-015021-pol2qm74	3097	12	LPS	lp	NNS
cord-015021-pol2qm74	3097	13	with	with	IN
cord-015021-pol2qm74	3097	14	two	two	CD
cord-015021-pol2qm74	3097	15	concentrations	concentration	NNS
cord-015021-pol2qm74	3097	16	of	of	IN
cord-015021-pol2qm74	3097	17	N	n	CD
cord-015021-pol2qm74	3097	18	-	-	HYPH
cord-015021-pol2qm74	3097	19	Monomethyl	Monomethyl	NNP
cord-015021-pol2qm74	3097	20	-	-	HYPH
cord-015021-pol2qm74	3097	21	L	L	NNP
cord-015021-pol2qm74	3097	22	-	-	HYPH
cord-015021-pol2qm74	3097	23	Arginine	Arginine	NNP
cord-015021-pol2qm74	3097	24	,	,	,
cord-015021-pol2qm74	3097	25	a	a	DT
cord-015021-pol2qm74	3097	26	nitric	nitric	NN
cord-015021-pol2qm74	3097	27	oxide	oxide	NN
cord-015021-pol2qm74	3097	28	inhibitor	inhibitor	NN
cord-015021-pol2qm74	3097	29	(	(	-LRB-
cord-015021-pol2qm74	3097	30	L	L	NNP
cord-015021-pol2qm74	3097	31	-	-	HYPH
cord-015021-pol2qm74	3097	32	NMMA	NMMA	NNP
cord-015021-pol2qm74	3097	33	2.5ug	2.5ug	CD
cord-015021-pol2qm74	3097	34	/	/	SYM
cord-015021-pol2qm74	3097	35	ml	ml	NN
cord-015021-pol2qm74	3097	36	,	,	,
cord-015021-pol2qm74	3097	37	10ug	10ug	NN
cord-015021-pol2qm74	3097	38	/	/	SYM
cord-015021-pol2qm74	3097	39	ml	ml	NN
cord-015021-pol2qm74	3097	40	)	)	-RRB-
cord-015021-pol2qm74	3097	41	.	.	.
cord-015021-pol2qm74	3098	1	Splenocyte	splenocyte	JJ
cord-015021-pol2qm74	3098	2	production	production	NN
cord-015021-pol2qm74	3098	3	of	of	IN
cord-015021-pol2qm74	3098	4	IL-10	IL-10	NNP
cord-015021-pol2qm74	3098	5	,	,	,
cord-015021-pol2qm74	3098	6	Interferon	interferon	NN
cord-015021-pol2qm74	3098	7	-	-	HYPH
cord-015021-pol2qm74	3098	8	gamma	gamma	NN
cord-015021-pol2qm74	3098	9	,	,	,
cord-015021-pol2qm74	3099	1	IL-2	IL-2	NNP
cord-015021-pol2qm74	3099	2	,	,	,
cord-015021-pol2qm74	3099	3	PGE2	PGE2	NNP
cord-015021-pol2qm74	3099	4	were	be	VBD
cord-015021-pol2qm74	3099	5	measured	measure	VBN
cord-015021-pol2qm74	3099	6	,	,	,
cord-015021-pol2qm74	3099	7	and	and	CC
cord-015021-pol2qm74	3099	8	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	3099	9	proliferative	proliferative	JJ
cord-015021-pol2qm74	3099	10	response	response	NN
cord-015021-pol2qm74	3099	11	examined	examine	VBD
cord-015021-pol2qm74	3099	12	.	.	.
cord-015021-pol2qm74	3100	1	RESULTS	result	NNS
cord-015021-pol2qm74	3100	2	:	:	:
cord-015021-pol2qm74	3100	3	IL-10	IL-10	NNP
cord-015021-pol2qm74	3101	1	production	production	NN
cord-015021-pol2qm74	3101	2	was	be	VBD
cord-015021-pol2qm74	3101	3	significantly	significantly	RB
cord-015021-pol2qm74	3101	4	suppressed	suppress	VBN
cord-015021-pol2qm74	3101	5	in	in	IN
cord-015021-pol2qm74	3101	6	thermal	thermal	JJ
cord-015021-pol2qm74	3101	7	injury	injury	NN
cord-015021-pol2qm74	3101	8	.	.	.
cord-015021-pol2qm74	3102	1	Exogenous	exogenous	JJ
cord-015021-pol2qm74	3102	2	L	L	NNP
cord-015021-pol2qm74	3102	3	-	-	HYPH
cord-015021-pol2qm74	3102	4	NMMA	NMMA	NNP
cord-015021-pol2qm74	3102	5	normalized	normalize	VBD
cord-015021-pol2qm74	3102	6	the	the	DT
cord-015021-pol2qm74	3102	7	suppression	suppression	NN
cord-015021-pol2qm74	3102	8	of	of	IN
cord-015021-pol2qm74	3102	9	11.-10	11.-10	CD
cord-015021-pol2qm74	3102	10	in	in	IN
cord-015021-pol2qm74	3102	11	a	a	DT
cord-015021-pol2qm74	3102	12	dose	dose	NN
cord-015021-pol2qm74	3102	13	-	-	HYPH
cord-015021-pol2qm74	3102	14	dependent	dependent	JJ
cord-015021-pol2qm74	3102	15	manner	manner	NN
cord-015021-pol2qm74	3102	16	,	,	,
cord-015021-pol2qm74	3102	17	indicating	indicate	VBG
cord-015021-pol2qm74	3102	18	nitric	nitric	JJ
cord-015021-pol2qm74	3102	19	oxide	oxide	NN
cord-015021-pol2qm74	3102	20	may	may	MD
cord-015021-pol2qm74	3102	21	modulate	modulate	VB
cord-015021-pol2qm74	3102	22	IL-10	IL-10	NNP
cord-015021-pol2qm74	3102	23	and	and	CC
cord-015021-pol2qm74	3102	24	Interferon	Interferon	NNP
cord-015021-pol2qm74	3102	25	-	-	HYPH
cord-015021-pol2qm74	3102	26	gamma	gamma	NN
cord-015021-pol2qm74	3102	27	production	production	NN
cord-015021-pol2qm74	3102	28	in	in	IN
cord-015021-pol2qm74	3102	29	thermal	thermal	JJ
cord-015021-pol2qm74	3102	30	injury	injury	NN
cord-015021-pol2qm74	3102	31	.	.	.
cord-015021-pol2qm74	3103	1	IL-10	IL-10	NNP
cord-015021-pol2qm74	3103	2	production	production	NN
cord-015021-pol2qm74	3103	3	is	be	VBZ
cord-015021-pol2qm74	3103	4	normal	normal	JJ
cord-015021-pol2qm74	3103	5	in	in	IN
cord-015021-pol2qm74	3103	6	EtOH	etoh	NN
cord-015021-pol2qm74	3103	7	-	-	HYPH
cord-015021-pol2qm74	3103	8	Burn	burn	NN
cord-015021-pol2qm74	3103	9	animals	animal	NNS
cord-015021-pol2qm74	3103	10	.	.	.
cord-015021-pol2qm74	3104	1	CONCLUSION	conclusion	NN
cord-015021-pol2qm74	3104	2	:	:	:
cord-015021-pol2qm74	3104	3	IL-10	IL-10	NNP
cord-015021-pol2qm74	3104	4	and	and	CC
cord-015021-pol2qm74	3104	5	Interferon	Interferon	NNP
cord-015021-pol2qm74	3104	6	-	-	HYPH
cord-015021-pol2qm74	3104	7	gamma	gamma	NN
cord-015021-pol2qm74	3104	8	production	production	NN
cord-015021-pol2qm74	3104	9	is	be	VBZ
cord-015021-pol2qm74	3104	10	altered	alter	VBN
cord-015021-pol2qm74	3104	11	in	in	IN
cord-015021-pol2qm74	3104	12	this	this	DT
cord-015021-pol2qm74	3104	13	murine	murine	JJ
cord-015021-pol2qm74	3104	14	thermal	thermal	JJ
cord-015021-pol2qm74	3104	15	injury	injury	NN
cord-015021-pol2qm74	3104	16	model	model	NN
cord-015021-pol2qm74	3104	17	,	,	,
cord-015021-pol2qm74	3104	18	and	and	CC
cord-015021-pol2qm74	3104	19	may	may	MD
cord-015021-pol2qm74	3104	20	contribute	contribute	VB
cord-015021-pol2qm74	3104	21	to	to	IN
cord-015021-pol2qm74	3104	22	this	this	DT
cord-015021-pol2qm74	3104	23	injury	injury	NN
cord-015021-pol2qm74	3104	24	-	-	HYPH
cord-015021-pol2qm74	3104	25	induced	induce	VBN
cord-015021-pol2qm74	3104	26	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	3104	27	.	.	.
cord-015021-pol2qm74	3105	1	Inhibition	inhibition	NN
cord-015021-pol2qm74	3105	2	of	of	IN
cord-015021-pol2qm74	3105	3	NO	no	DT
cord-015021-pol2qm74	3105	4	synthesis	synthesis	NN
cord-015021-pol2qm74	3105	5	normalizes	normalize	VBZ
cord-015021-pol2qm74	3105	6	IL-10	IL-10	NNP
cord-015021-pol2qm74	3105	7	production	production	NN
cord-015021-pol2qm74	3105	8	and	and	CC
cord-015021-pol2qm74	3105	9	should	should	MD
cord-015021-pol2qm74	3105	10	be	be	VB
cord-015021-pol2qm74	3105	11	investigated	investigate	VBN
cord-015021-pol2qm74	3105	12	further	further	RB
cord-015021-pol2qm74	3105	13	as	as	IN
cord-015021-pol2qm74	3105	14	an	an	DT
cord-015021-pol2qm74	3105	15	immanomodalator	immanomodalator	NN
cord-015021-pol2qm74	3105	16	in	in	IN
cord-015021-pol2qm74	3105	17	thermal	thermal	JJ
cord-015021-pol2qm74	3105	18	injury	injury	NN
cord-015021-pol2qm74	3105	19	.	.	.
cord-015021-pol2qm74	3106	1	Surgery	surgery	NN
cord-015021-pol2qm74	3106	2	,	,	,
cord-015021-pol2qm74	3106	3	infection	infection	NN
cord-015021-pol2qm74	3106	4	and	and	CC
cord-015021-pol2qm74	3106	5	inflammation	inflammation	NN
cord-015021-pol2qm74	3106	6	results	result	NNS
cord-015021-pol2qm74	3106	7	in	in	IN
cord-015021-pol2qm74	3106	8	the	the	DT
cord-015021-pol2qm74	3106	9	production	production	NN
cord-015021-pol2qm74	3106	10	of	of	IN
cord-015021-pol2qm74	3106	11	pro	pro	JJ
cord-015021-pol2qm74	3106	12	-	-	JJ
cord-015021-pol2qm74	3106	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3106	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	3106	15	which	which	WDT
cord-015021-pol2qm74	3106	16	mediate	mediate	VBP
cord-015021-pol2qm74	3106	17	metabolic	metabolic	JJ
cord-015021-pol2qm74	3106	18	and	and	CC
cord-015021-pol2qm74	3106	19	immunologic	immunologic	JJ
cord-015021-pol2qm74	3106	20	host	host	NN
cord-015021-pol2qm74	3106	21	responses	response	NNS
cord-015021-pol2qm74	3106	22	.	.	.
cord-015021-pol2qm74	3107	1	The	the	DT
cord-015021-pol2qm74	3107	2	aim	aim	NN
cord-015021-pol2qm74	3107	3	of	of	IN
cord-015021-pol2qm74	3107	4	this	this	DT
cord-015021-pol2qm74	3107	5	study	study	NN
cord-015021-pol2qm74	3107	6	was	be	VBD
cord-015021-pol2qm74	3107	7	to	to	TO
cord-015021-pol2qm74	3107	8	characterise	characterise	VB
cord-015021-pol2qm74	3107	9	the	the	DT
cord-015021-pol2qm74	3107	10	elaboration	elaboration	NN
cord-015021-pol2qm74	3107	11	of	of	IN
cord-015021-pol2qm74	3107	12	cytokine	cytokine	NN
cord-015021-pol2qm74	3107	13	release	release	NN
cord-015021-pol2qm74	3107	14	following	follow	VBG
cord-015021-pol2qm74	3107	15	a	a	DT
cord-015021-pol2qm74	3107	16	variety	variety	NN
cord-015021-pol2qm74	3107	17	of	of	IN
cord-015021-pol2qm74	3107	18	surgical	surgical	JJ
cord-015021-pol2qm74	3107	19	procedures	procedure	NNS
cord-015021-pol2qm74	3107	20	.	.	.
cord-015021-pol2qm74	3108	1	Twenty	twenty	CD
cord-015021-pol2qm74	3108	2	one	one	CD
cord-015021-pol2qm74	3108	3	patients	patient	NNS
cord-015021-pol2qm74	3108	4	undergoing	undergo	VBG
cord-015021-pol2qm74	3108	5	elective	elective	JJ
cord-015021-pol2qm74	3108	6	intermediate	intermediate	JJ
cord-015021-pol2qm74	3108	7	,	,	,
cord-015021-pol2qm74	3108	8	hip	hip	NN
cord-015021-pol2qm74	3108	9	,	,	,
cord-015021-pol2qm74	3108	10	knee	knee	NN
cord-015021-pol2qm74	3108	11	and	and	CC
cord-015021-pol2qm74	3108	12	major	major	JJ
cord-015021-pol2qm74	3108	13	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	3108	14	surgery	surgery	NN
cord-015021-pol2qm74	3108	15	were	be	VBD
cord-015021-pol2qm74	3108	16	studied	study	VBN
cord-015021-pol2qm74	3108	17	.	.	.
cord-015021-pol2qm74	3109	1	Levels	level	NNS
cord-015021-pol2qm74	3109	2	of	of	IN
cord-015021-pol2qm74	3109	3	interleukin-1	interleukin-1	NN
cord-015021-pol2qm74	3109	4	(	(	-LRB-
cord-015021-pol2qm74	3109	5	I1	i1	NN
cord-015021-pol2qm74	3109	6	-	-	HYPH
cord-015021-pol2qm74	3109	7	1	1	CD
cord-015021-pol2qm74	3109	8	)	)	-RRB-
cord-015021-pol2qm74	3109	9	,	,	,
cord-015021-pol2qm74	3109	10	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	3109	11	(	(	-LRB-
cord-015021-pol2qm74	3109	12	I1	I1	NNP
cord-015021-pol2qm74	3109	13	-	-	HYPH
cord-015021-pol2qm74	3109	14	6	6	CD
cord-015021-pol2qm74	3109	15	)	)	-RRB-
cord-015021-pol2qm74	3109	16	,	,	,
cord-015021-pol2qm74	3109	17	the	the	DT
cord-015021-pol2qm74	3109	18	interleukin-1	interleukin-1	NNP
cord-015021-pol2qm74	3109	19	receptor	receptor	NN
cord-015021-pol2qm74	3109	20	antagonist	antagonist	NN
cord-015021-pol2qm74	3109	21	(	(	-LRB-
cord-015021-pol2qm74	3109	22	I1	I1	NNP
cord-015021-pol2qm74	3109	23	-	-	HYPH
cord-015021-pol2qm74	3109	24	1RA	1RA	NNP
cord-015021-pol2qm74	3109	25	)	)	-RRB-
cord-015021-pol2qm74	3109	26	and	and	CC
cord-015021-pol2qm74	3109	27	the	the	DT
cord-015021-pol2qm74	3109	28	acute	acute	JJ
cord-015021-pol2qm74	3109	29	phase	phase	NN
cord-015021-pol2qm74	3109	30	C	c	NN
cord-015021-pol2qm74	3109	31	-	-	HYPH
cord-015021-pol2qm74	3109	32	reactive	reactive	JJ
cord-015021-pol2qm74	3109	33	protein	protein	NN
cord-015021-pol2qm74	3109	34	(	(	-LRB-
cord-015021-pol2qm74	3109	35	CRP	CRP	NNP
cord-015021-pol2qm74	3109	36	)	)	-RRB-
cord-015021-pol2qm74	3109	37	were	be	VBD
cord-015021-pol2qm74	3109	38	measured	measure	VBN
cord-015021-pol2qm74	3109	39	in	in	IN
cord-015021-pol2qm74	3109	40	bloods	blood	NNS
cord-015021-pol2qm74	3109	41	drawn	draw	VBN
cord-015021-pol2qm74	3109	42	0	0	CD
cord-015021-pol2qm74	3109	43	,	,	,
cord-015021-pol2qm74	3109	44	1	1	CD
cord-015021-pol2qm74	3109	45	,	,	,
cord-015021-pol2qm74	3109	46	2	2	CD
cord-015021-pol2qm74	3109	47	,	,	,
cord-015021-pol2qm74	3109	48	4	4	CD
cord-015021-pol2qm74	3109	49	,	,	,
cord-015021-pol2qm74	3109	50	6	6	CD
cord-015021-pol2qm74	3109	51	,	,	,
cord-015021-pol2qm74	3109	52	12	12	CD
cord-015021-pol2qm74	3109	53	,	,	,
cord-015021-pol2qm74	3109	54	24	24	CD
cord-015021-pol2qm74	3109	55	and	and	CC
cord-015021-pol2qm74	3109	56	48	48	CD
cord-015021-pol2qm74	3109	57	hours	hour	NNS
cord-015021-pol2qm74	3109	58	following	follow	VBG
cord-015021-pol2qm74	3109	59	operation	operation	NN
cord-015021-pol2qm74	3109	60	.	.	.
cord-015021-pol2qm74	3110	1	A	a	DT
cord-015021-pol2qm74	3110	2	portion	portion	NN
cord-015021-pol2qm74	3110	3	of	of	IN
cord-015021-pol2qm74	3110	4	the	the	DT
cord-015021-pol2qm74	3110	5	results	result	NNS
cord-015021-pol2qm74	3110	6	are	be	VBP
cord-015021-pol2qm74	3110	7	shown	show	VBN
cord-015021-pol2qm74	3110	8	(	(	-LRB-
cord-015021-pol2qm74	3110	9	mean	mean	VB
cord-015021-pol2qm74	3110	10	-+	-+	NNP
cord-015021-pol2qm74	3110	11	sem	sem	NNP
cord-015021-pol2qm74	3110	12	)	)	-RRB-
cord-015021-pol2qm74	3110	13	.	.	.
cord-015021-pol2qm74	3111	1	135	135	CD
cord-015021-pol2qm74	3111	2	+	+	SYM
cord-015021-pol2qm74	3111	3	37	37	CD
cord-015021-pol2qm74	3111	4	1738-+843	1738-+843	CD
cord-015021-pol2qm74	3112	1	145_+24	145_+24	LS
cord-015021-pol2qm74	3112	2	One	one	CD
cord-015021-pol2qm74	3112	3	and	and	CC
cord-015021-pol2qm74	3112	4	two	two	CD
cord-015021-pol2qm74	3112	5	factor	factor	NN
cord-015021-pol2qm74	3112	6	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	3112	7	;	;	:
cord-015021-pol2qm74	3113	1	*	*	NFP
cord-015021-pol2qm74	3113	2	p<0.0002	p<0.0002	NNP
cord-015021-pol2qm74	3113	3	,	,	,
cord-015021-pol2qm74	3113	4	#	#	NN
cord-015021-pol2qm74	3113	5	p<0.0001	p<0.0001	XX
cord-015021-pol2qm74	3113	6	,	,	,
cord-015021-pol2qm74	3113	7	§	§	NN
cord-015021-pol2qm74	3113	8	p<0.0009	p<0.0009	NNP
cord-015021-pol2qm74	3113	9	,	,	,
cord-015021-pol2qm74	3114	1	¶p<0.0014	¶p<0.0014	.
cord-015021-pol2qm74	3115	1	,	,	,
cord-015021-pol2qm74	3115	2	for	for	IN
cord-015021-pol2qm74	3115	3	differences	difference	NNS
cord-015021-pol2qm74	3115	4	between	between	IN
cord-015021-pol2qm74	3115	5	groups	group	NNS
cord-015021-pol2qm74	3115	6	I1	I1	NNP
cord-015021-pol2qm74	3115	7	-	-	HYPH
cord-015021-pol2qm74	3115	8	1	1	NNP
cord-015021-pol2qm74	3115	9	was	be	VBD
cord-015021-pol2qm74	3115	10	not	not	RB
cord-015021-pol2qm74	3115	11	detected	detect	VBN
cord-015021-pol2qm74	3115	12	at	at	IN
cord-015021-pol2qm74	3115	13	any	any	DT
cord-015021-pol2qm74	3115	14	time	time	NN
cord-015021-pol2qm74	3115	15	point	point	NN
cord-015021-pol2qm74	3115	16	.	.	.
cord-015021-pol2qm74	3116	1	Both	both	DT
cord-015021-pol2qm74	3116	2	II	II	NNP
cord-015021-pol2qm74	3116	3	-	-	HYPH
cord-015021-pol2qm74	3116	4	IRA	IRA	NNP
cord-015021-pol2qm74	3116	5	and	and	CC
cord-015021-pol2qm74	3116	6	I1	I1	NNP
cord-015021-pol2qm74	3116	7	-	-	HYPH
cord-015021-pol2qm74	3116	8	6	6	CD
cord-015021-pol2qm74	3116	9	increased	increase	VBD
cord-015021-pol2qm74	3116	10	after	after	IN
cord-015021-pol2qm74	3116	11	surgery	surgery	NN
cord-015021-pol2qm74	3116	12	.	.	.
cord-015021-pol2qm74	3117	1	Maximum	maximum	JJ
cord-015021-pol2qm74	3117	2	responses	response	NNS
cord-015021-pol2qm74	3117	3	occurred	occur	VBD
cord-015021-pol2qm74	3117	4	following	follow	VBG
cord-015021-pol2qm74	3117	5	major	major	JJ
cord-015021-pol2qm74	3117	6	GIT	git	NN
cord-015021-pol2qm74	3117	7	and	and	CC
cord-015021-pol2qm74	3117	8	hip	hip	NN
cord-015021-pol2qm74	3117	9	surgery	surgery	NN
cord-015021-pol2qm74	3117	10	,	,	,
cord-015021-pol2qm74	3117	11	minimal	minimal	JJ
cord-015021-pol2qm74	3117	12	responses	response	NNS
cord-015021-pol2qm74	3117	13	were	be	VBD
cord-015021-pol2qm74	3117	14	seen	see	VBN
cord-015021-pol2qm74	3117	15	after	after	IN
cord-015021-pol2qm74	3117	16	intermediate	intermediate	JJ
cord-015021-pol2qm74	3117	17	and	and	CC
cord-015021-pol2qm74	3117	18	knee	knee	NN
cord-015021-pol2qm74	3117	19	surgery	surgery	NN
cord-015021-pol2qm74	3117	20	.	.	.
cord-015021-pol2qm74	3118	1	II	II	NNP
cord-015021-pol2qm74	3118	2	-	-	HYPH
cord-015021-pol2qm74	3118	3	IRA	IRA	NNP
cord-015021-pol2qm74	3118	4	levels	level	NNS
cord-015021-pol2qm74	3118	5	increased	increase	VBD
cord-015021-pol2qm74	3118	6	within	within	IN
cord-015021-pol2qm74	3118	7	two	two	CD
cord-015021-pol2qm74	3118	8	hours	hour	NNS
cord-015021-pol2qm74	3118	9	and	and	CC
cord-015021-pol2qm74	3118	10	remained	remain	VBD
cord-015021-pol2qm74	3118	11	elevated	elevated	JJ
cord-015021-pol2qm74	3118	12	for	for	IN
cord-015021-pol2qm74	3118	13	24	24	CD
cord-015021-pol2qm74	3118	14	hours	hour	NNS
cord-015021-pol2qm74	3118	15	;	;	:
cord-015021-pol2qm74	3118	16	the	the	DT
cord-015021-pol2qm74	3118	17	B	B	NNP
cord-015021-pol2qm74	3118	18	-	-	HYPH
cord-015021-pol2qm74	3118	19	IRA	IRA	NNP
cord-015021-pol2qm74	3118	20	increase	increase	NN
cord-015021-pol2qm74	3118	21	was	be	VBD
cord-015021-pol2qm74	3118	22	a	a	DT
cord-015021-pol2qm74	3118	23	thousand	thousand	CD
cord-015021-pol2qm74	3118	24	fold	fold	VB
cord-015021-pol2qm74	3118	25	greater	great	JJR
cord-015021-pol2qm74	3118	26	than	than	IN
cord-015021-pol2qm74	3118	27	the	the	DT
cord-015021-pol2qm74	3118	28	rise	rise	NN
cord-015021-pol2qm74	3118	29	in	in	IN
cord-015021-pol2qm74	3118	30	I1	i1	NN
cord-015021-pol2qm74	3118	31	-	-	HYPH
cord-015021-pol2qm74	3118	32	6	6	CD
cord-015021-pol2qm74	3118	33	levels	level	NNS
cord-015021-pol2qm74	3118	34	.	.	.
cord-015021-pol2qm74	3119	1	I1	i1	NN
cord-015021-pol2qm74	3119	2	-	-	HYPH
cord-015021-pol2qm74	3119	3	6	6	CD
cord-015021-pol2qm74	3119	4	levels	level	NNS
cord-015021-pol2qm74	3119	5	increased	increase	VBD
cord-015021-pol2qm74	3119	6	up	up	RB
cord-015021-pol2qm74	3119	7	to	to	TO
cord-015021-pol2qm74	3119	8	24	24	CD
cord-015021-pol2qm74	3119	9	hours	hour	NNS
cord-015021-pol2qm74	3119	10	after	after	IN
cord-015021-pol2qm74	3119	11	surgery	surgery	NN
cord-015021-pol2qm74	3119	12	.	.	.
cord-015021-pol2qm74	3120	1	CRP	CRP	NNP
cord-015021-pol2qm74	3120	2	levels	level	NNS
cord-015021-pol2qm74	3120	3	reflected	reflect	VBD
cord-015021-pol2qm74	3120	4	maximum	maximum	JJ
cord-015021-pol2qm74	3120	5	II	II	NNP
cord-015021-pol2qm74	3120	6	-	-	HYPH
cord-015021-pol2qm74	3120	7	IRA	IRA	NNP
cord-015021-pol2qm74	3120	8	and	and	CC
cord-015021-pol2qm74	3120	9	I1	I1	NNP
cord-015021-pol2qm74	3120	10	-	-	HYPH
cord-015021-pol2qm74	3120	11	6	6	CD
cord-015021-pol2qm74	3120	12	levels	level	NNS
cord-015021-pol2qm74	3120	13	(	(	-LRB-
cord-015021-pol2qm74	3120	14	R2=.676	R2=.676	NNP
cord-015021-pol2qm74	3120	15	,	,	,
cord-015021-pol2qm74	3120	16	p<0.0001	p<0.0001	NNP
cord-015021-pol2qm74	3120	17	and	and	CC
cord-015021-pol2qm74	3120	18	R2=.282	R2=.282	NNS
cord-015021-pol2qm74	3120	19	,	,	,
cord-015021-pol2qm74	3120	20	p<0.04	p<0.04	NN
cord-015021-pol2qm74	3120	21	respectively	respectively	RB
cord-015021-pol2qm74	3120	22	)	)	-RRB-
cord-015021-pol2qm74	3120	23	.	.	.
cord-015021-pol2qm74	3121	1	High	high	JJ
cord-015021-pol2qm74	3121	2	II-1RA	II-1RA	NNS
cord-015021-pol2qm74	3121	3	and	and	CC
cord-015021-pol2qm74	3121	4	I1	i1	NN
cord-015021-pol2qm74	3121	5	-	-	HYPH
cord-015021-pol2qm74	3121	6	6	6	CD
cord-015021-pol2qm74	3121	7	levels	level	NNS
cord-015021-pol2qm74	3121	8	reflect	reflect	VBP
cord-015021-pol2qm74	3121	9	major	major	JJ
cord-015021-pol2qm74	3121	10	surgery	surgery	NN
cord-015021-pol2qm74	3121	11	,	,	,
cord-015021-pol2qm74	3121	12	however	however	RB
cord-015021-pol2qm74	3121	13	the	the	DT
cord-015021-pol2qm74	3121	14	II	II	NNP
cord-015021-pol2qm74	3121	15	-	-	HYPH
cord-015021-pol2qm74	3121	16	IRA	IRA	NNP
cord-015021-pol2qm74	3121	17	response	response	NN
cord-015021-pol2qm74	3121	18	is	be	VBZ
cord-015021-pol2qm74	3121	19	more	more	RBR
cord-015021-pol2qm74	3121	20	rapid	rapid	JJ
cord-015021-pol2qm74	3121	21	and	and	CC
cord-015021-pol2qm74	3121	22	of	of	IN
cord-015021-pol2qm74	3121	23	greater	great	JJR
cord-015021-pol2qm74	3121	24	magnitude	magnitude	NN
cord-015021-pol2qm74	3121	25	.	.	.
cord-015021-pol2qm74	3122	1	The	the	DT
cord-015021-pol2qm74	3122	2	strong	strong	JJ
cord-015021-pol2qm74	3122	3	I1	i1	NN
cord-015021-pol2qm74	3122	4	-	-	HYPH
cord-015021-pol2qm74	3122	5	1RA	1ra	CD
cord-015021-pol2qm74	3122	6	correlation	correlation	NN
cord-015021-pol2qm74	3122	7	with	with	IN
cord-015021-pol2qm74	3122	8	CRP	CRP	NNP
cord-015021-pol2qm74	3122	9	may	may	MD
cord-015021-pol2qm74	3122	10	indicate	indicate	VB
cord-015021-pol2qm74	3122	11	that	that	IN
cord-015021-pol2qm74	3122	12	this	this	DT
cord-015021-pol2qm74	3122	13	regulatory	regulatory	JJ
cord-015021-pol2qm74	3122	14	cytokine	cytokine	NN
cord-015021-pol2qm74	3122	15	is	be	VBZ
cord-015021-pol2qm74	3122	16	itself	-PRON-	PRP
cord-015021-pol2qm74	3122	17	a	a	DT
cord-015021-pol2qm74	3122	18	mediator	mediator	NN
cord-015021-pol2qm74	3122	19	of	of	IN
cord-015021-pol2qm74	3122	20	host	host	NN
cord-015021-pol2qm74	3122	21	responses	response	NNS
cord-015021-pol2qm74	3122	22	to	to	IN
cord-015021-pol2qm74	3122	23	surgery	surgery	NN
cord-015021-pol2qm74	3122	24	.	.	.
cord-015021-pol2qm74	3123	1	Dept	Dept	NNP
cord-015021-pol2qm74	3123	2	.	.	NNP
cord-015021-pol2qm74	3123	3	of	of	IN
cord-015021-pol2qm74	3123	4	Surgery	surgery	NN
cord-015021-pol2qm74	3123	5	,	,	,
cord-015021-pol2qm74	3123	6	Meath	Meath	NNP
cord-015021-pol2qm74	3123	7	/	/	SYM
cord-015021-pol2qm74	3123	8	Adelaide	Adelaide	NNP
cord-015021-pol2qm74	3123	9	Hospitals	Hospitals	NNPS
cord-015021-pol2qm74	3123	10	,	,	,
cord-015021-pol2qm74	3123	11	Heytesbury	Heytesbury	NNP
cord-015021-pol2qm74	3123	12	St.	St.	NNP
cord-015021-pol2qm74	3123	13	,	,	,
cord-015021-pol2qm74	3123	14	Dublin	Dublin	NNP
cord-015021-pol2qm74	3123	15	8	8	CD
cord-015021-pol2qm74	3123	16	,	,	,
cord-015021-pol2qm74	3123	17	Ireland	Ireland	NNP
cord-015021-pol2qm74	3123	18	.	.	.
cord-015021-pol2qm74	3124	1	CHANGE	CHANGE	NNP
cord-015021-pol2qm74	3124	2	OF	of	IN
cord-015021-pol2qm74	3124	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	3124	4	AND	and	CC
cord-015021-pol2qm74	3124	5	SOLUBLE	SOLUBLE	NNP
cord-015021-pol2qm74	3124	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	3124	7	RECEPTOR	receptor	NN
cord-015021-pol2qm74	3124	8	LEVELS	levels	NN
cord-015021-pol2qm74	3124	9	AFTER	after	IN
cord-015021-pol2qm74	3124	10	SURGERY	surgery	NN
cord-015021-pol2qm74	3124	11	S.	S.	NNP
cord-015021-pol2qm74	3124	12	Hisano	Hisano	NNP
cord-015021-pol2qm74	3124	13	,	,	,
cord-015021-pol2qm74	3124	14	K.	K.	NNP
cord-015021-pol2qm74	3124	15	Sakamoto	Sakamoto	NNP
cord-015021-pol2qm74	3124	16	,	,	,
cord-015021-pol2qm74	3124	17	S.	S.	NNP
cord-015021-pol2qm74	3124	18	Mita	Mita	NNP
cord-015021-pol2qm74	3124	19	,	,	,
cord-015021-pol2qm74	3124	20	T.	T.	NNP
cord-015021-pol2qm74	3124	21	Ishiko	Ishiko	NNP
cord-015021-pol2qm74	3124	22	,	,	,
cord-015021-pol2qm74	3124	23	M.	M.	NNP
cord-015021-pol2qm74	3124	24	Ogawa	Ogawa	NNP
cord-015021-pol2qm74	3124	25	[	[	-LRB-
cord-015021-pol2qm74	3124	26	Objectives	Objectives	NNP
cord-015021-pol2qm74	3124	27	]	]	-RRB-
cord-015021-pol2qm74	3124	28	Under	under	IN
cord-015021-pol2qm74	3124	29	surgical	surgical	JJ
cord-015021-pol2qm74	3124	30	stress	stress	NN
cord-015021-pol2qm74	3124	31	,	,	.
cord-015021-pol2qm74	3125	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3125	2	plays	play	VBZ
cord-015021-pol2qm74	3125	3	a	a	DT
cord-015021-pol2qm74	3125	4	main	main	JJ
cord-015021-pol2qm74	3125	5	role	role	NN
cord-015021-pol2qm74	3125	6	in	in	IN
cord-015021-pol2qm74	3125	7	producing	produce	VBG
cord-015021-pol2qm74	3125	8	acute	acute	JJ
cord-015021-pol2qm74	3125	9	phase	phase	NN
cord-015021-pol2qm74	3125	10	proteins	protein	NNS
cord-015021-pol2qm74	3125	11	and	and	CC
cord-015021-pol2qm74	3125	12	contributes	contribute	VBZ
cord-015021-pol2qm74	3125	13	to	to	TO
cord-015021-pol2qm74	3125	14	host	host	VB
cord-015021-pol2qm74	3125	15	defense	defense	NN
cord-015021-pol2qm74	3125	16	mechanism	mechanism	NN
cord-015021-pol2qm74	3125	17	.	.	.
cord-015021-pol2qm74	3126	1	Soluble	soluble	JJ
cord-015021-pol2qm74	3126	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3126	3	receptor	receptor	NN
cord-015021-pol2qm74	3126	4	(	(	-LRB-
cord-015021-pol2qm74	3126	5	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3126	6	)	)	-RRB-
cord-015021-pol2qm74	3126	7	is	be	VBZ
cord-015021-pol2qm74	3126	8	considered	consider	VBN
cord-015021-pol2qm74	3126	9	to	to	TO
cord-015021-pol2qm74	3126	10	be	be	VB
cord-015021-pol2qm74	3126	11	agonistic	agonistic	JJ
cord-015021-pol2qm74	3126	12	to	to	IN
cord-015021-pol2qm74	3126	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	3126	14	,	,	,
cord-015021-pol2qm74	3126	15	unlike	unlike	IN
cord-015021-pol2qm74	3126	16	other	other	JJ
cord-015021-pol2qm74	3126	17	soluble	soluble	JJ
cord-015021-pol2qm74	3126	18	type	type	NN
cord-015021-pol2qm74	3126	19	receptors	receptor	NNS
cord-015021-pol2qm74	3126	20	of	of	IN
cord-015021-pol2qm74	3126	21	cytokines	cytokine	NNS
cord-015021-pol2qm74	3126	22	.	.	.
cord-015021-pol2qm74	3127	1	Here	here	RB
cord-015021-pol2qm74	3127	2	we	-PRON-	PRP
cord-015021-pol2qm74	3127	3	measured	measure	VBD
cord-015021-pol2qm74	3127	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	3127	5	and	and	CC
cord-015021-pol2qm74	3127	6	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3127	7	levels	level	NNS
cord-015021-pol2qm74	3127	8	in	in	IN
cord-015021-pol2qm74	3127	9	the	the	DT
cord-015021-pol2qm74	3127	10	serum	serum	NN
cord-015021-pol2qm74	3127	11	and	and	CC
cord-015021-pol2qm74	3127	12	drain	drain	VB
cord-015021-pol2qm74	3127	13	fluid	fluid	NN
cord-015021-pol2qm74	3127	14	from	from	IN
cord-015021-pol2qm74	3127	15	surgical	surgical	JJ
cord-015021-pol2qm74	3127	16	field	field	NN
cord-015021-pol2qm74	3127	17	in	in	IN
cord-015021-pol2qm74	3127	18	order	order	NN
cord-015021-pol2qm74	3127	19	to	to	TO
cord-015021-pol2qm74	3127	20	investigate	investigate	VB
cord-015021-pol2qm74	3127	21	the	the	DT
cord-015021-pol2qm74	3127	22	changes	change	NNS
cord-015021-pol2qm74	3127	23	of	of	IN
cord-015021-pol2qm74	3127	24	IL-6	IL-6	NNP
cord-015021-pol2qm74	3127	25	and	and	CC
cord-015021-pol2qm74	3127	26	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3127	27	after	after	IN
cord-015021-pol2qm74	3127	28	surgery	surgery	NN
cord-015021-pol2qm74	3127	29	and	and	CC
cord-015021-pol2qm74	3127	30	their	-PRON-	PRP$
cord-015021-pol2qm74	3127	31	origins	origin	NNS
cord-015021-pol2qm74	3127	32	.	.	.
cord-015021-pol2qm74	3128	1	[	[	-LRB-
cord-015021-pol2qm74	3128	2	Materials	material	NNS
cord-015021-pol2qm74	3128	3	and	and	CC
cord-015021-pol2qm74	3128	4	Methods	Methods	NNPS
cord-015021-pol2qm74	3128	5	]	]	-RRB-
cord-015021-pol2qm74	3128	6	Serum	serum	NN
cord-015021-pol2qm74	3128	7	and	and	CC
cord-015021-pol2qm74	3128	8	drain	drain	VB
cord-015021-pol2qm74	3128	9	fluid	fluid	NN
cord-015021-pol2qm74	3128	10	samples	sample	NNS
cord-015021-pol2qm74	3128	11	from	from	IN
cord-015021-pol2qm74	3128	12	21	21	CD
cord-015021-pol2qm74	3128	13	cases	case	NNS
cord-015021-pol2qm74	3128	14	(	(	-LRB-
cord-015021-pol2qm74	3128	15	6	6	CD
cord-015021-pol2qm74	3128	16	of	of	IN
cord-015021-pol2qm74	3128	17	esophagectomy	esophagectomy	NN
cord-015021-pol2qm74	3128	18	and	and	CC
cord-015021-pol2qm74	3128	19	15	15	CD
cord-015021-pol2qm74	3128	20	of	of	IN
cord-015021-pol2qm74	3128	21	gastrectomy	gastrectomy	NN
cord-015021-pol2qm74	3128	22	)	)	-RRB-
cord-015021-pol2qm74	3128	23	were	be	VBD
cord-015021-pol2qm74	3128	24	serially	serially	RB
cord-015021-pol2qm74	3128	25	collected	collect	VBN
cord-015021-pol2qm74	3128	26	before	before	RB
cord-015021-pol2qm74	3128	27	and	and	CC
cord-015021-pol2qm74	3128	28	after	after	IN
cord-015021-pol2qm74	3128	29	surgery	surgery	NN
cord-015021-pol2qm74	3128	30	.	.	.
cord-015021-pol2qm74	3129	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3129	2	and	and	CC
cord-015021-pol2qm74	3129	3	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3129	4	levels	level	NNS
cord-015021-pol2qm74	3129	5	were	be	VBD
cord-015021-pol2qm74	3129	6	measured	measure	VBN
cord-015021-pol2qm74	3129	7	by	by	IN
cord-015021-pol2qm74	3129	8	ELISA	ELISA	NNP
cord-015021-pol2qm74	3129	9	.	.	.
cord-015021-pol2qm74	3130	1	[	[	-LRB-
cord-015021-pol2qm74	3130	2	Results	result	NNS
cord-015021-pol2qm74	3130	3	]	]	-RRB-
cord-015021-pol2qm74	3130	4	(	(	-LRB-
cord-015021-pol2qm74	3130	5	1	1	LS
cord-015021-pol2qm74	3130	6	)	)	-RRB-
cord-015021-pol2qm74	3130	7	Serum	serum	NN
cord-015021-pol2qm74	3131	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3131	2	:	:	:
cord-015021-pol2qm74	3131	3	All	all	DT
cord-015021-pol2qm74	3131	4	cases	case	NNS
cord-015021-pol2qm74	3131	5	reached	reach	VBD
cord-015021-pol2qm74	3131	6	the	the	DT
cord-015021-pol2qm74	3131	7	maximum	maximum	JJ
cord-015021-pol2qm74	3131	8	level	level	NN
cord-015021-pol2qm74	3131	9	on	on	IN
cord-015021-pol2qm74	3131	10	POD	POD	NNP
cord-015021-pol2qm74	3131	11	-	-	HYPH
cord-015021-pol2qm74	3131	12	l	l	NNP
cord-015021-pol2qm74	3131	13	,	,	,
cord-015021-pol2qm74	3131	14	more	more	RBR
cord-015021-pol2qm74	3131	15	precisely	precisely	RB
cord-015021-pol2qm74	3131	16	3	3	CD
cord-015021-pol2qm74	3131	17	-	-	SYM
cord-015021-pol2qm74	3131	18	6	6	CD
cord-015021-pol2qm74	3131	19	hours	hour	NNS
cord-015021-pol2qm74	3131	20	after	after	IN
cord-015021-pol2qm74	3131	21	operation	operation	NN
cord-015021-pol2qm74	3131	22	.	.	.
cord-015021-pol2qm74	3132	1	(	(	-LRB-
cord-015021-pol2qm74	3132	2	2	2	LS
cord-015021-pol2qm74	3132	3	)	)	-RRB-
cord-015021-pol2qm74	3132	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	3132	5	in	in	IN
cord-015021-pol2qm74	3132	6	the	the	DT
cord-015021-pol2qm74	3132	7	drain	drain	NN
cord-015021-pol2qm74	3132	8	:	:	:
cord-015021-pol2qm74	3132	9	Maximal	maximal	JJ
cord-015021-pol2qm74	3132	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	3132	11	levels	level	NNS
cord-015021-pol2qm74	3132	12	in	in	IN
cord-015021-pol2qm74	3132	13	the	the	DT
cord-015021-pol2qm74	3132	14	drain	drain	NN
cord-015021-pol2qm74	3132	15	were	be	VBD
cord-015021-pol2qm74	3132	16	recognized	recognize	VBN
cord-015021-pol2qm74	3132	17	3	3	CD
cord-015021-pol2qm74	3132	18	-	-	SYM
cord-015021-pol2qm74	3132	19	6	6	CD
cord-015021-pol2qm74	3132	20	hours	hour	NNS
cord-015021-pol2qm74	3132	21	after	after	IN
cord-015021-pol2qm74	3132	22	operation	operation	NN
cord-015021-pol2qm74	3132	23	,	,	,
cord-015021-pol2qm74	3132	24	at	at	IN
cord-015021-pol2qm74	3132	25	almost	almost	RB
cord-015021-pol2qm74	3132	26	the	the	DT
cord-015021-pol2qm74	3132	27	same	same	JJ
cord-015021-pol2qm74	3132	28	time	time	NN
cord-015021-pol2qm74	3132	29	as	as	IN
cord-015021-pol2qm74	3132	30	serum	serum	NN
cord-015021-pol2qm74	3132	31	IL-6	IL-6	NNP
cord-015021-pol2qm74	3132	32	.	.	.
cord-015021-pol2qm74	3133	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	3133	2	the	the	DT
cord-015021-pol2qm74	3133	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	3133	4	values	value	NNS
cord-015021-pol2qm74	3133	5	in	in	IN
cord-015021-pol2qm74	3133	6	the	the	DT
cord-015021-pol2qm74	3133	7	drain	drain	NN
cord-015021-pol2qm74	3133	8	were	be	VBD
cord-015021-pol2qm74	3133	9	much	much	RB
cord-015021-pol2qm74	3133	10	higher	high	JJR
cord-015021-pol2qm74	3133	11	,	,	,
cord-015021-pol2qm74	3133	12	about	about	RB
cord-015021-pol2qm74	3133	13	100	100	CD
cord-015021-pol2qm74	3133	14	times	time	NNS
cord-015021-pol2qm74	3133	15	,	,	,
cord-015021-pol2qm74	3133	16	than	than	IN
cord-015021-pol2qm74	3133	17	those	those	DT
cord-015021-pol2qm74	3133	18	in	in	IN
cord-015021-pol2qm74	3133	19	serum	serum	NN
cord-015021-pol2qm74	3133	20	.	.	.
cord-015021-pol2qm74	3134	1	(	(	-LRB-
cord-015021-pol2qm74	3134	2	3	3	LS
cord-015021-pol2qm74	3134	3	)	)	-RRB-
cord-015021-pol2qm74	3134	4	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3134	5	in	in	IN
cord-015021-pol2qm74	3134	6	the	the	DT
cord-015021-pol2qm74	3134	7	serum	serum	NN
cord-015021-pol2qm74	3134	8	:	:	:
cord-015021-pol2qm74	3135	1	All	all	DT
cord-015021-pol2qm74	3135	2	cases	case	NNS
cord-015021-pol2qm74	3135	3	reached	reach	VBD
cord-015021-pol2qm74	3135	4	minimum	minimum	JJ
cord-015021-pol2qm74	3135	5	levels	level	NNS
cord-015021-pol2qm74	3135	6	3	3	CD
cord-015021-pol2qm74	3135	7	-	-	SYM
cord-015021-pol2qm74	3135	8	12	12	CD
cord-015021-pol2qm74	3135	9	hours	hour	NNS
cord-015021-pol2qm74	3135	10	after	after	IN
cord-015021-pol2qm74	3135	11	operation	operation	NN
cord-015021-pol2qm74	3135	12	and	and	CC
cord-015021-pol2qm74	3135	13	recovered	recover	VBD
cord-015021-pol2qm74	3135	14	to	to	IN
cord-015021-pol2qm74	3135	15	the	the	DT
cord-015021-pol2qm74	3135	16	preoperative	preoperative	JJ
cord-015021-pol2qm74	3135	17	levels	level	NNS
cord-015021-pol2qm74	3135	18	a	a	DT
cord-015021-pol2qm74	3135	19	few	few	JJ
cord-015021-pol2qm74	3135	20	days	day	NNS
cord-015021-pol2qm74	3135	21	later	later	RB
cord-015021-pol2qm74	3135	22	(	(	-LRB-
cord-015021-pol2qm74	3135	23	decrease	decrease	NN
cord-015021-pol2qm74	3135	24	ratio	ratio	NN
cord-015021-pol2qm74	3135	25	:	:	:
cord-015021-pol2qm74	3135	26	43.9	43.9	CD
cord-015021-pol2qm74	3135	27	+	+	SYM
cord-015021-pol2qm74	3135	28	5.6~	5.6~	CD
cord-015021-pol2qm74	3135	29	,	,	,
cord-015021-pol2qm74	3135	30	,	,	,
cord-015021-pol2qm74	3135	31	range	range	NN
cord-015021-pol2qm74	3135	32	:	:	:
cord-015021-pol2qm74	3135	33	9	9	CD
cord-015021-pol2qm74	3135	34	-	-	SYM
cord-015021-pol2qm74	3135	35	84~	84~	CD
cord-015021-pol2qm74	3135	36	'	'	''
cord-015021-pol2qm74	3135	37	)	)	-RRB-
cord-015021-pol2qm74	3135	38	.	.	.
cord-015021-pol2qm74	3136	1	(	(	-LRB-
cord-015021-pol2qm74	3136	2	4	4	LS
cord-015021-pol2qm74	3136	3	)	)	-RRB-
cord-015021-pol2qm74	3136	4	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3136	5	in	in	IN
cord-015021-pol2qm74	3136	6	the	the	DT
cord-015021-pol2qm74	3136	7	drain	drain	NN
cord-015021-pol2qm74	3136	8	:	:	:
cord-015021-pol2qm74	3136	9	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3136	10	levels	level	NNS
cord-015021-pol2qm74	3136	11	in	in	IN
cord-015021-pol2qm74	3136	12	the	the	DT
cord-015021-pol2qm74	3136	13	drain	drain	NN
cord-015021-pol2qm74	3136	14	showed	show	VBD
cord-015021-pol2qm74	3136	15	almost	almost	RB
cord-015021-pol2qm74	3136	16	the	the	DT
cord-015021-pol2qm74	3136	17	same	same	JJ
cord-015021-pol2qm74	3136	18	value	value	NN
cord-015021-pol2qm74	3136	19	and	and	CC
cord-015021-pol2qm74	3136	20	change	change	NN
cord-015021-pol2qm74	3136	21	as	as	IN
cord-015021-pol2qm74	3136	22	serum	serum	NN
cord-015021-pol2qm74	3136	23	slL-6R.	sll-6r.	ADD
cord-015021-pol2qm74	3136	24	[	[	-LRB-
cord-015021-pol2qm74	3136	25	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3136	26	]	]	-RRB-
cord-015021-pol2qm74	3136	27	(	(	-LRB-
cord-015021-pol2qm74	3136	28	1	1	LS
cord-015021-pol2qm74	3136	29	)	)	-RRB-
cord-015021-pol2qm74	3136	30	IL-6	IL-6	NNP
cord-015021-pol2qm74	3136	31	is	be	VBZ
cord-015021-pol2qm74	3136	32	produced	produce	VBN
cord-015021-pol2qm74	3136	33	from	from	IN
cord-015021-pol2qm74	3136	34	the	the	DT
cord-015021-pol2qm74	3136	35	cells	cell	NNS
cord-015021-pol2qm74	3136	36	gathering	gather	VBG
cord-015021-pol2qm74	3136	37	around	around	IN
cord-015021-pol2qm74	3136	38	operative	operative	JJ
cord-015021-pol2qm74	3136	39	fields	field	NNS
cord-015021-pol2qm74	3136	40	whereas	whereas	IN
cord-015021-pol2qm74	3136	41	slL-6R	slL-6R	NNP
cord-015021-pol2qm74	3136	42	is	be	VBZ
cord-015021-pol2qm74	3136	43	considered	consider	VBN
cord-015021-pol2qm74	3136	44	to	to	TO
cord-015021-pol2qm74	3136	45	be	be	VB
cord-015021-pol2qm74	3136	46	produced	produce	VBN
cord-015021-pol2qm74	3136	47	in	in	IN
cord-015021-pol2qm74	3136	48	the	the	DT
cord-015021-pol2qm74	3136	49	cells	cell	NNS
cord-015021-pol2qm74	3136	50	which	which	WDT
cord-015021-pol2qm74	3136	51	do	do	VBP
cord-015021-pol2qm74	3136	52	not	not	RB
cord-015021-pol2qm74	3136	53	gather	gather	VB
cord-015021-pol2qm74	3136	54	around	around	IN
cord-015021-pol2qm74	3136	55	the	the	DT
cord-015021-pol2qm74	3136	56	operative	operative	JJ
cord-015021-pol2qm74	3136	57	fields	field	NNS
cord-015021-pol2qm74	3136	58	.	.	.
cord-015021-pol2qm74	3137	1	(	(	-LRB-
cord-015021-pol2qm74	3137	2	2	2	LS
cord-015021-pol2qm74	3137	3	)	)	-RRB-
cord-015021-pol2qm74	3138	1	There	there	EX
cord-015021-pol2qm74	3138	2	may	may	MD
cord-015021-pol2qm74	3138	3	be	be	VB
cord-015021-pol2qm74	3138	4	a	a	DT
cord-015021-pol2qm74	3138	5	mechanism	mechanism	NN
cord-015021-pol2qm74	3138	6	that	that	WDT
cord-015021-pol2qm74	3138	7	down	down	RB
cord-015021-pol2qm74	3138	8	-	-	HYPH
cord-015021-pol2qm74	3138	9	regulates	regulate	VBZ
cord-015021-pol2qm74	3138	10	slL-6R	slL-6R	NNS
cord-015021-pol2qm74	3138	11	in	in	IN
cord-015021-pol2qm74	3138	12	the	the	DT
cord-015021-pol2qm74	3138	13	early	early	JJ
cord-015021-pol2qm74	3138	14	stage	stage	NN
cord-015021-pol2qm74	3138	15	of	of	IN
cord-015021-pol2qm74	3138	16	surgery	surgery	NN
cord-015021-pol2qm74	3138	17	.	.	.
cord-015021-pol2qm74	3139	1	[	[	-LRB-
cord-015021-pol2qm74	3139	2	Objectives	Objectives	NNP
cord-015021-pol2qm74	3139	3	]	]	-RRB-
cord-015021-pol2qm74	3139	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	3139	5	plays	play	VBZ
cord-015021-pol2qm74	3139	6	an	an	DT
cord-015021-pol2qm74	3139	7	important	important	JJ
cord-015021-pol2qm74	3139	8	role	role	NN
cord-015021-pol2qm74	3139	9	in	in	IN
cord-015021-pol2qm74	3139	10	host	host	NN
cord-015021-pol2qm74	3139	11	defense	defense	NN
cord-015021-pol2qm74	3139	12	in	in	IN
cord-015021-pol2qm74	3139	13	the	the	DT
cord-015021-pol2qm74	3139	14	early	early	JJ
cord-015021-pol2qm74	3139	15	stage	stage	NN
cord-015021-pol2qm74	3139	16	after	after	IN
cord-015021-pol2qm74	3139	17	surgery	surgery	NN
cord-015021-pol2qm74	3139	18	.	.	.
cord-015021-pol2qm74	3140	1	In	in	IN
cord-015021-pol2qm74	3140	2	the	the	DT
cord-015021-pol2qm74	3140	3	present	present	JJ
cord-015021-pol2qm74	3140	4	study	study	NN
cord-015021-pol2qm74	3140	5	,	,	,
cord-015021-pol2qm74	3140	6	we	-PRON-	PRP
cord-015021-pol2qm74	3140	7	examined	examine	VBD
cord-015021-pol2qm74	3140	8	changes	change	NNS
cord-015021-pol2qm74	3140	9	in	in	IN
cord-015021-pol2qm74	3140	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	3140	11	concentration	concentration	NN
cord-015021-pol2qm74	3140	12	after	after	IN
cord-015021-pol2qm74	3140	13	major	major	JJ
cord-015021-pol2qm74	3140	14	thoracoabdominal	thoracoabdominal	JJ
cord-015021-pol2qm74	3140	15	surgery	surgery	NN
cord-015021-pol2qm74	3140	16	and	and	CC
cord-015021-pol2qm74	3140	17	elucidated	elucidate	VBD
cord-015021-pol2qm74	3140	18	the	the	DT
cord-015021-pol2qm74	3140	19	effect	effect	NN
cord-015021-pol2qm74	3140	20	of	of	IN
cord-015021-pol2qm74	3140	21	surgical	surgical	JJ
cord-015021-pol2qm74	3140	22	trauma	trauma	NN
cord-015021-pol2qm74	3140	23	and	and	CC
cord-015021-pol2qm74	3140	24	factors	factor	NNS
cord-015021-pol2qm74	3140	25	influencing	influence	VBG
cord-015021-pol2qm74	3140	26	postoperative	postoperative	JJ
cord-015021-pol2qm74	3140	27	elevation	elevation	NN
cord-015021-pol2qm74	3140	28	of	of	IN
cord-015021-pol2qm74	3140	29	serum	serum	NN
cord-015021-pol2qm74	3140	30	IL-6	IL-6	NNP
cord-015021-pol2qm74	3140	31	.	.	.
cord-015021-pol2qm74	3141	1	[	[	-LRB-
cord-015021-pol2qm74	3141	2	Materials	material	NNS
cord-015021-pol2qm74	3141	3	and	and	CC
cord-015021-pol2qm74	3141	4	Methods	Methods	NNPS
cord-015021-pol2qm74	3141	5	]	]	-RRB-
cord-015021-pol2qm74	3141	6	Thirty	thirty	CD
cord-015021-pol2qm74	3141	7	-	-	HYPH
cord-015021-pol2qm74	3141	8	eight	eight	CD
cord-015021-pol2qm74	3141	9	patients	patient	NNS
cord-015021-pol2qm74	3141	10	undergoing	undergo	VBG
cord-015021-pol2qm74	3141	11	elective	elective	JJ
cord-015021-pol2qm74	3141	12	surgery	surgery	NN
cord-015021-pol2qm74	3141	13	of	of	IN
cord-015021-pol2qm74	3141	14	the	the	DT
cord-015021-pol2qm74	3141	15	thoracoabdomen	thoracoabdoman	NNS
cord-015021-pol2qm74	3141	16	were	be	VBD
cord-015021-pol2qm74	3141	17	classified	classify	VBN
cord-015021-pol2qm74	3141	18	into	into	IN
cord-015021-pol2qm74	3141	19	6	6	CD
cord-015021-pol2qm74	3141	20	groups	group	NNS
cord-015021-pol2qm74	3141	21	according	accord	VBG
cord-015021-pol2qm74	3141	22	to	to	IN
cord-015021-pol2qm74	3141	23	the	the	DT
cord-015021-pol2qm74	3141	24	location	location	NN
cord-015021-pol2qm74	3141	25	of	of	IN
cord-015021-pol2qm74	3141	26	the	the	DT
cord-015021-pol2qm74	3141	27	operation	operation	NN
cord-015021-pol2qm74	3141	28	.	.	.
cord-015021-pol2qm74	3142	1	Bloods	blood	NNS
cord-015021-pol2qm74	3142	2	and	and	CC
cord-015021-pol2qm74	3142	3	drain	drain	NN
cord-015021-pol2qm74	3142	4	fluids	fluid	NNS
cord-015021-pol2qm74	3142	5	were	be	VBD
cord-015021-pol2qm74	3142	6	serially	serially	RB
cord-015021-pol2qm74	3142	7	obtained	obtain	VBN
cord-015021-pol2qm74	3142	8	and	and	CC
cord-015021-pol2qm74	3142	9	samples	sample	NNS
cord-015021-pol2qm74	3142	10	were	be	VBD
cord-015021-pol2qm74	3142	11	frozen	freeze	VBN
cord-015021-pol2qm74	3142	12	until	until	IN
cord-015021-pol2qm74	3142	13	measured	measure	VBN
cord-015021-pol2qm74	3142	14	,	,	,
cord-015021-pol2qm74	3142	15	keukocytes	keukocytes	NNP
cord-015021-pol2qm74	3142	16	were	be	VBD
cord-015021-pol2qm74	3142	17	simultaneously	simultaneously	RB
cord-015021-pol2qm74	3142	18	collected	collect	VBN
cord-015021-pol2qm74	3142	19	for	for	IN
cord-015021-pol2qm74	3142	20	Northern	northern	JJ
cord-015021-pol2qm74	3142	21	blot	blot	NN
cord-015021-pol2qm74	3142	22	analysis	analysis	NN
cord-015021-pol2qm74	3142	23	.	.	.
cord-015021-pol2qm74	3143	1	Concentration	concentration	NN
cord-015021-pol2qm74	3143	2	of	of	IN
cord-015021-pol2qm74	3143	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	3143	4	was	be	VBD
cord-015021-pol2qm74	3143	5	measured	measure	VBN
cord-015021-pol2qm74	3143	6	by	by	IN
cord-015021-pol2qm74	3143	7	ELISA	ELISA	NNP
cord-015021-pol2qm74	3143	8	and	and	CC
cord-015021-pol2qm74	3143	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	3143	10	mRNA	mRNA	NNP
cord-015021-pol2qm74	3143	11	was	be	VBD
cord-015021-pol2qm74	3143	12	detected	detect	VBN
cord-015021-pol2qm74	3143	13	by	by	IN
cord-015021-pol2qm74	3143	14	Northern	Northern	NNP
cord-015021-pol2qm74	3143	15	blotting	blotting	NN
cord-015021-pol2qm74	3143	16	after	after	IN
cord-015021-pol2qm74	3143	17	total	total	JJ
cord-015021-pol2qm74	3143	18	RNA	RNA	NNP
cord-015021-pol2qm74	3143	19	was	be	VBD
cord-015021-pol2qm74	3143	20	extracted	extract	VBN
cord-015021-pol2qm74	3143	21	by	by	IN
cord-015021-pol2qm74	3143	22	the	the	DT
cord-015021-pol2qm74	3143	23	Acid	Acid	NNP
cord-015021-pol2qm74	3143	24	Guanidium	Guanidium	NNP
cord-015021-pol2qm74	3143	25	Phenol	Phenol	NNP
cord-015021-pol2qm74	3143	26	Chloroform	Chloroform	NNP
cord-015021-pol2qm74	3143	27	method	method	NN
cord-015021-pol2qm74	3143	28	.	.	.
cord-015021-pol2qm74	3144	1	[	[	-LRB-
cord-015021-pol2qm74	3144	2	Results	result	NNS
cord-015021-pol2qm74	3144	3	]	]	-RRB-
cord-015021-pol2qm74	3144	4	(	(	-LRB-
cord-015021-pol2qm74	3144	5	1	1	CD
cord-015021-pol2qm74	3144	6	)	)	-RRB-
cord-015021-pol2qm74	3145	1	Serum	serum	NN
cord-015021-pol2qm74	3145	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3145	3	levels	level	NNS
cord-015021-pol2qm74	3145	4	reached	reach	VBD
cord-015021-pol2qm74	3145	5	the	the	DT
cord-015021-pol2qm74	3145	6	maximum	maximum	JJ
cord-015021-pol2qm74	3145	7	concentration	concentration	NN
cord-015021-pol2qm74	3145	8	on	on	IN
cord-015021-pol2qm74	3145	9	the	the	DT
cord-015021-pol2qm74	3145	10	1st	1st	JJ
cord-015021-pol2qm74	3145	11	postoperative	postoperative	JJ
cord-015021-pol2qm74	3145	12	day	day	NN
cord-015021-pol2qm74	3145	13	in	in	IN
cord-015021-pol2qm74	3145	14	all	all	DT
cord-015021-pol2qm74	3145	15	patients	patient	NNS
cord-015021-pol2qm74	3145	16	.	.	.
cord-015021-pol2qm74	3146	1	(	(	-LRB-
cord-015021-pol2qm74	3146	2	2	2	LS
cord-015021-pol2qm74	3146	3	)	)	-RRB-
cord-015021-pol2qm74	3147	1	The	the	DT
cord-015021-pol2qm74	3147	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3147	3	peak	peak	NN
cord-015021-pol2qm74	3147	4	was	be	VBD
cord-015021-pol2qm74	3147	5	significantly	significantly	RB
cord-015021-pol2qm74	3147	6	correlated	correlate	VBN
cord-015021-pol2qm74	3147	7	with	with	IN
cord-015021-pol2qm74	3147	8	surgical	surgical	JJ
cord-015021-pol2qm74	3147	9	trauma	trauma	NN
cord-015021-pol2qm74	3147	10	as	as	IN
cord-015021-pol2qm74	3147	11	defined	define	VBN
cord-015021-pol2qm74	3147	12	by	by	IN
cord-015021-pol2qm74	3147	13	the	the	DT
cord-015021-pol2qm74	3147	14	operation	operation	NN
cord-015021-pol2qm74	3147	15	length	length	NN
cord-015021-pol2qm74	3147	16	and	and	CC
cord-015021-pol2qm74	3147	17	the	the	DT
cord-015021-pol2qm74	3147	18	volume	volume	NN
cord-015021-pol2qm74	3147	19	of	of	IN
cord-015021-pol2qm74	3147	20	blood	blood	NN
cord-015021-pol2qm74	3147	21	loss	loss	NN
cord-015021-pol2qm74	3147	22	during	during	IN
cord-015021-pol2qm74	3147	23	operation	operation	NN
cord-015021-pol2qm74	3147	24	(	(	-LRB-
cord-015021-pol2qm74	3147	25	r=0.554	r=0.554	NNS
cord-015021-pol2qm74	3147	26	,	,	,
cord-015021-pol2qm74	3147	27	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	3147	28	,	,	,
cord-015021-pol2qm74	3147	29	r=0.427	r=0.427	NN
cord-015021-pol2qm74	3147	30	,	,	,
cord-015021-pol2qm74	3147	31	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	3147	32	,	,	,
cord-015021-pol2qm74	3147	33	respectively	respectively	RB
cord-015021-pol2qm74	3147	34	)	)	-RRB-
cord-015021-pol2qm74	3147	35	.	.	.
cord-015021-pol2qm74	3148	1	(	(	-LRB-
cord-015021-pol2qm74	3148	2	3	3	LS
cord-015021-pol2qm74	3148	3	)	)	-RRB-
cord-015021-pol2qm74	3149	1	The	the	DT
cord-015021-pol2qm74	3149	2	peak	peak	NN
cord-015021-pol2qm74	3149	3	concentration	concentration	NN
cord-015021-pol2qm74	3149	4	of	of	IN
cord-015021-pol2qm74	3149	5	serum	serum	NN
cord-015021-pol2qm74	3149	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	3149	7	in	in	IN
cord-015021-pol2qm74	3149	8	patients	patient	NNS
cord-015021-pol2qm74	3149	9	undergoing	undergo	VBG
cord-015021-pol2qm74	3149	10	esophagectomy	esophagectomy	NN
cord-015021-pol2qm74	3149	11	was	be	VBD
cord-015021-pol2qm74	3149	12	significantly	significantly	RB
cord-015021-pol2qm74	3149	13	higher	high	JJR
cord-015021-pol2qm74	3149	14	than	than	IN
cord-015021-pol2qm74	3149	15	in	in	IN
cord-015021-pol2qm74	3149	16	those	those	DT
cord-015021-pol2qm74	3149	17	undergoing	undergo	VBG
cord-015021-pol2qm74	3149	18	pancreaticoduodenectomy	pancreaticoduodenectomy	NN
cord-015021-pol2qm74	3149	19	(	(	-LRB-
cord-015021-pol2qm74	3149	20	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	3149	21	)	)	-RRB-
cord-015021-pol2qm74	3149	22	,	,	,
cord-015021-pol2qm74	3149	23	despite	despite	IN
cord-015021-pol2qm74	3149	24	a	a	DT
cord-015021-pol2qm74	3149	25	similar	similar	JJ
cord-015021-pol2qm74	3149	26	degree	degree	NN
cord-015021-pol2qm74	3149	27	of	of	IN
cord-015021-pol2qm74	3149	28	surgical	surgical	JJ
cord-015021-pol2qm74	3149	29	trauma	trauma	NN
cord-015021-pol2qm74	3149	30	.	.	.
cord-015021-pol2qm74	3150	1	(	(	-LRB-
cord-015021-pol2qm74	3150	2	4	4	LS
cord-015021-pol2qm74	3150	3	)	)	-RRB-
cord-015021-pol2qm74	3151	1	Peak	Peak	NNP
cord-015021-pol2qm74	3151	2	1L-6	1l-6	JJ
cord-015021-pol2qm74	3151	3	concentration	concentration	NN
cord-015021-pol2qm74	3151	4	observed	observe	VBD
cord-015021-pol2qm74	3151	5	in	in	IN
cord-015021-pol2qm74	3151	6	a	a	DT
cord-015021-pol2qm74	3151	7	patient	patient	NN
cord-015021-pol2qm74	3151	8	who	who	WP
cord-015021-pol2qm74	3151	9	underwent	undergo	VBD
cord-015021-pol2qm74	3151	10	esophagectomy	esophagectomy	NN
cord-015021-pol2qm74	3151	11	was	be	VBD
cord-015021-pol2qm74	3151	12	about	about	RB
cord-015021-pol2qm74	3151	13	100	100	CD
cord-015021-pol2qm74	3151	14	fold	fold	VBP
cord-015021-pol2qm74	3151	15	greater	great	JJR
cord-015021-pol2qm74	3151	16	in	in	IN
cord-015021-pol2qm74	3151	17	the	the	DT
cord-015021-pol2qm74	3151	18	drain	drain	NN
cord-015021-pol2qm74	3151	19	fluid	fluid	NN
cord-015021-pol2qm74	3151	20	of	of	IN
cord-015021-pol2qm74	3151	21	thorax	thorax	NN
cord-015021-pol2qm74	3151	22	than	than	IN
cord-015021-pol2qm74	3151	23	in	in	IN
cord-015021-pol2qm74	3151	24	the	the	DT
cord-015021-pol2qm74	3151	25	peripheral	peripheral	JJ
cord-015021-pol2qm74	3151	26	blood	blood	NN
cord-015021-pol2qm74	3151	27	.	.	.
cord-015021-pol2qm74	3152	1	(	(	-LRB-
cord-015021-pol2qm74	3152	2	5	5	LS
cord-015021-pol2qm74	3152	3	)	)	-RRB-
cord-015021-pol2qm74	3152	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	3152	5	mRNA	mRNA	NNP
cord-015021-pol2qm74	3152	6	was	be	VBD
cord-015021-pol2qm74	3152	7	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3152	8	in	in	IN
cord-015021-pol2qm74	3152	9	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	3152	10	from	from	IN
cord-015021-pol2qm74	3152	11	thoracic	thoracic	JJ
cord-015021-pol2qm74	3152	12	and	and	CC
cord-015021-pol2qm74	3152	13	abdominal	abdominal	JJ
cord-015021-pol2qm74	3152	14	exudate	exudate	NN
cord-015021-pol2qm74	3152	15	at	at	IN
cord-015021-pol2qm74	3152	16	6	6	CD
cord-015021-pol2qm74	3152	17	,	,	,
cord-015021-pol2qm74	3152	18	24	24	CD
cord-015021-pol2qm74	3152	19	and	and	CC
cord-015021-pol2qm74	3152	20	48	48	CD
cord-015021-pol2qm74	3152	21	hours	hour	NNS
cord-015021-pol2qm74	3152	22	after	after	IN
cord-015021-pol2qm74	3152	23	surgery	surgery	NN
cord-015021-pol2qm74	3152	24	.	.	.
cord-015021-pol2qm74	3153	1	In	in	IN
cord-015021-pol2qm74	3153	2	contrast	contrast	NN
cord-015021-pol2qm74	3153	3	,	,	,
cord-015021-pol2qm74	3153	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	3153	5	mRNA	mRNA	NNP
cord-015021-pol2qm74	3153	6	could	could	MD
cord-015021-pol2qm74	3153	7	not	not	RB
cord-015021-pol2qm74	3153	8	be	be	VB
cord-015021-pol2qm74	3153	9	detected	detect	VBN
cord-015021-pol2qm74	3153	10	in	in	IN
cord-015021-pol2qm74	3153	11	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	3153	12	from	from	IN
cord-015021-pol2qm74	3153	13	the	the	DT
cord-015021-pol2qm74	3153	14	peripheral	peripheral	JJ
cord-015021-pol2qm74	3153	15	blood	blood	NN
cord-015021-pol2qm74	3153	16	.	.	.
cord-015021-pol2qm74	3154	1	[	[	-LRB-
cord-015021-pol2qm74	3154	2	Conclusion	conclusion	NN
cord-015021-pol2qm74	3154	3	]	]	-RRB-
cord-015021-pol2qm74	3154	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	3154	5	is	be	VBZ
cord-015021-pol2qm74	3154	6	mainly	mainly	RB
cord-015021-pol2qm74	3154	7	produced	produce	VBN
cord-015021-pol2qm74	3154	8	in	in	IN
cord-015021-pol2qm74	3154	9	the	the	DT
cord-015021-pol2qm74	3154	10	operative	operative	JJ
cord-015021-pol2qm74	3154	11	field	field	NN
cord-015021-pol2qm74	3154	12	and	and	CC
cord-015021-pol2qm74	3154	13	subsequently	subsequently	RB
cord-015021-pol2qm74	3154	14	enter	enter	VB
cord-015021-pol2qm74	3154	15	the	the	DT
cord-015021-pol2qm74	3154	16	peripheral	peripheral	JJ
cord-015021-pol2qm74	3154	17	blood	blood	NN
cord-015021-pol2qm74	3154	18	to	to	TO
cord-015021-pol2qm74	3154	19	induce	induce	VB
cord-015021-pol2qm74	3154	20	cytokinemia	cytokinemia	NN
cord-015021-pol2qm74	3154	21	.	.	.
cord-015021-pol2qm74	3155	1	The	the	DT
cord-015021-pol2qm74	3155	2	operation	operation	NN
cord-015021-pol2qm74	3155	3	length	length	NN
cord-015021-pol2qm74	3155	4	,	,	,
cord-015021-pol2qm74	3155	5	volume	volume	NN
cord-015021-pol2qm74	3155	6	of	of	IN
cord-015021-pol2qm74	3155	7	blood	blood	NN
cord-015021-pol2qm74	3155	8	loss	loss	NN
cord-015021-pol2qm74	3155	9	and	and	CC
cord-015021-pol2qm74	3155	10	thoracotomy	thoracotomy	NN
cord-015021-pol2qm74	3155	11	are	be	VBP
cord-015021-pol2qm74	3155	12	factors	factor	NNS
cord-015021-pol2qm74	3155	13	influencing	influence	VBG
cord-015021-pol2qm74	3155	14	the	the	DT
cord-015021-pol2qm74	3155	15	concentration	concentration	NN
cord-015021-pol2qm74	3155	16	of	of	IN
cord-015021-pol2qm74	3155	17	cytokine	cytokine	NN
cord-015021-pol2qm74	3155	18	in	in	IN
cord-015021-pol2qm74	3155	19	the	the	DT
cord-015021-pol2qm74	3155	20	blood	blood	NN
cord-015021-pol2qm74	3155	21	.	.	.
cord-015021-pol2qm74	3156	1	Zaragoza	Zaragoza	NNP
cord-015021-pol2qm74	3157	1	SPAIN	SPAIN	NNP
cord-015021-pol2qm74	3157	2	Age	Age	NNP
cord-015021-pol2qm74	3157	3	may	may	MD
cord-015021-pol2qm74	3157	4	be	be	VB
cord-015021-pol2qm74	3157	5	an	an	DT
cord-015021-pol2qm74	3157	6	important	important	JJ
cord-015021-pol2qm74	3157	7	factor	factor	NN
cord-015021-pol2qm74	3157	8	influencing	influence	VBG
cord-015021-pol2qm74	3157	9	the	the	DT
cord-015021-pol2qm74	3157	10	function	function	NN
cord-015021-pol2qm74	3157	11	of	of	IN
cord-015021-pol2qm74	3157	12	immunocompeteut	immunocompeteut	JJ
cord-015021-pol2qm74	3157	13	cells	cell	NNS
cord-015021-pol2qm74	3157	14	releasing	release	VBG
cord-015021-pol2qm74	3157	15	cytokines	cytokine	NNS
cord-015021-pol2qm74	3157	16	after	after	IN
cord-015021-pol2qm74	3157	17	both	both	CC
cord-015021-pol2qm74	3157	18	accidental	accidental	JJ
cord-015021-pol2qm74	3157	19	and	and	CC
cord-015021-pol2qm74	3157	20	surgical	surgical	JJ
cord-015021-pol2qm74	3157	21	trauma	trauma	NN
cord-015021-pol2qm74	3158	1	The	the	DT
cord-015021-pol2qm74	3158	2	aim	aim	NN
cord-015021-pol2qm74	3158	3	of	of	IN
cord-015021-pol2qm74	3158	4	the	the	DT
cord-015021-pol2qm74	3158	5	present	present	JJ
cord-015021-pol2qm74	3158	6	paper	paper	NN
cord-015021-pol2qm74	3158	7	is	be	VBZ
cord-015021-pol2qm74	3158	8	to	to	TO
cord-015021-pol2qm74	3158	9	ascertain	ascertain	VB
cord-015021-pol2qm74	3158	10	if	if	IN
cord-015021-pol2qm74	3158	11	patients	patient	NNS
cord-015021-pol2qm74	3158	12	(	(	-LRB-
cord-015021-pol2qm74	3158	13	PTS	PTS	NNP
cord-015021-pol2qm74	3158	14	)	)	-RRB-
cord-015021-pol2qm74	3158	15	over	over	IN
cord-015021-pol2qm74	3158	16	60	60	CD
cord-015021-pol2qm74	3158	17	years	year	NNS
cord-015021-pol2qm74	3158	18	old	old	JJ
cord-015021-pol2qm74	3158	19	show	show	VBP
cord-015021-pol2qm74	3158	20	a	a	DT
cord-015021-pol2qm74	3158	21	different	different	JJ
cord-015021-pol2qm74	3158	22	serum	serum	NN
cord-015021-pol2qm74	3158	23	level	level	NN
cord-015021-pol2qm74	3158	24	cytokine	cytokine	NN
cord-015021-pol2qm74	3158	25	pattern	pattern	NN
cord-015021-pol2qm74	3158	26	than	than	IN
cord-015021-pol2qm74	3158	27	PTS	PTS	NNP
cord-015021-pol2qm74	3158	28	under	under	IN
cord-015021-pol2qm74	3158	29	60	60	CD
cord-015021-pol2qm74	3158	30	after	after	IN
cord-015021-pol2qm74	3158	31	a	a	DT
cord-015021-pol2qm74	3158	32	standard	standard	JJ
cord-015021-pol2qm74	3158	33	surgical	surgical	JJ
cord-015021-pol2qm74	3158	34	procedure	procedure	NN
cord-015021-pol2qm74	3158	35	considered	consider	VBN
cord-015021-pol2qm74	3158	36	as	as	IN
cord-015021-pol2qm74	3158	37	a	a	DT
cord-015021-pol2qm74	3158	38	"	"	``
cord-015021-pol2qm74	3158	39	medium	medium	JJ
cord-015021-pol2qm74	3158	40	strength	strength	NN
cord-015021-pol2qm74	3158	41	trauma	trauma	NN
cord-015021-pol2qm74	3158	42	"	"	''
cord-015021-pol2qm74	3158	43	.	.	.
cord-015021-pol2qm74	3159	1	PATIENTS	patient	NNS
cord-015021-pol2qm74	3159	2	AND	and	CC
cord-015021-pol2qm74	3159	3	METHODS	method	NNS
cord-015021-pol2qm74	3159	4	:	:	:
cord-015021-pol2qm74	3160	1	33	33	CD
cord-015021-pol2qm74	3160	2	PTS(22	PTS(22	NNP
cord-015021-pol2qm74	3160	3	females	female	NNS
cord-015021-pol2qm74	3161	1	11	11	CD
cord-015021-pol2qm74	3161	2	males)with	males)with	NNP
cord-015021-pol2qm74	3161	3	gallstone	gallstone	NN
cord-015021-pol2qm74	3161	4	disease	disease	NN
cord-015021-pol2qm74	3161	5	were	be	VBD
cord-015021-pol2qm74	3161	6	perspectively	perspectively	RB
cord-015021-pol2qm74	3161	7	studied	study	VBN
cord-015021-pol2qm74	3161	8	,	,	,
cord-015021-pol2qm74	3161	9	PTS	PTS	NNP
cord-015021-pol2qm74	3161	10	were	be	VBD
cord-015021-pol2qm74	3161	11	allotted	allot	VBN
cord-015021-pol2qm74	3161	12	in	in	IN
cord-015021-pol2qm74	3161	13	two	two	CD
cord-015021-pol2qm74	3161	14	groups	group	NNS
cord-015021-pol2qm74	3161	15	:	:	:
cord-015021-pol2qm74	3162	1	Gr	Gr	NNP
cord-015021-pol2qm74	3162	2	.	.	.
cord-015021-pol2qm74	3163	1	A:17	A:17	NNP
cord-015021-pol2qm74	3163	2	PTS	PTS	NNP
cord-015021-pol2qm74	3163	3	under	under	IN
cord-015021-pol2qm74	3163	4	60	60	CD
cord-015021-pol2qm74	3163	5	years(mean	years(mean	CD
cord-015021-pol2qm74	3163	6	age:49.5	age:49.5	XX
cord-015021-pol2qm74	3164	1	+	+	CC
cord-015021-pol2qm74	3165	1	-7)Gr	-7)Gr	NNP
cord-015021-pol2qm74	3165	2	.	.	.
cord-015021-pol2qm74	3166	1	B:16	B:16	NNP
cord-015021-pol2qm74	3166	2	PTS	PTS	NNP
cord-015021-pol2qm74	3166	3	over	over	IN
cord-015021-pol2qm74	3166	4	60	60	CD
cord-015021-pol2qm74	3166	5	years(mean	years(mean	JJ
cord-015021-pol2qm74	3166	6	age:65.5_+5	age:65.5_+5	NNP
cord-015021-pol2qm74	3166	7	)	)	-RRB-
cord-015021-pol2qm74	3166	8	.	.	.
cord-015021-pol2qm74	3167	1	All	all	DT
cord-015021-pol2qm74	3167	2	PTS	PTS	NNP
cord-015021-pol2qm74	3167	3	underwent	undergo	VBD
cord-015021-pol2qm74	3167	4	cholecystectomy	cholecystectomy	NN
cord-015021-pol2qm74	3167	5	and	and	CC
cord-015021-pol2qm74	3167	6	cholangiography	cholangiography	NN
cord-015021-pol2qm74	3167	7	.	.	.
cord-015021-pol2qm74	3168	1	6	6	CD
cord-015021-pol2qm74	3168	2	PTS	pts	NN
cord-015021-pol2qm74	3168	3	in	in	IN
cord-015021-pol2qm74	3168	4	Gr	Gr	NNP
cord-015021-pol2qm74	3168	5	.	.	.
cord-015021-pol2qm74	3169	1	A	a	NN
cord-015021-pol2qm74	3169	2	and	and	CC
cord-015021-pol2qm74	3169	3	7	7	CD
cord-015021-pol2qm74	3169	4	PTS	PTS	NNP
cord-015021-pol2qm74	3169	5	in	in	IN
cord-015021-pol2qm74	3169	6	Gr	Gr	NNP
cord-015021-pol2qm74	3169	7	.	.	.
cord-015021-pol2qm74	3170	1	B	b	NN
cord-015021-pol2qm74	3170	2	underwent	undergo	VBD
cord-015021-pol2qm74	3170	3	common	common	JJ
cord-015021-pol2qm74	3170	4	duct	duct	NN
cord-015021-pol2qm74	3170	5	exploration	exploration	NN
cord-015021-pol2qm74	3170	6	.	.	.
cord-015021-pol2qm74	3171	1	1	1	CD
cord-015021-pol2qm74	3171	2	spbintercctomy	spbintercctomy	NN
cord-015021-pol2qm74	3171	3	was	be	VBD
cord-015021-pol2qm74	3171	4	performed	perform	VBN
cord-015021-pol2qm74	3171	5	in	in	IN
cord-015021-pol2qm74	3171	6	each	each	DT
cord-015021-pol2qm74	3171	7	group	group	NN
cord-015021-pol2qm74	3171	8	.	.	.
cord-015021-pol2qm74	3172	1	On	on	IN
cord-015021-pol2qm74	3172	2	the	the	DT
cord-015021-pol2qm74	3172	3	day	day	NN
cord-015021-pol2qm74	3172	4	of	of	IN
cord-015021-pol2qm74	3172	5	surgery	surgery	NN
cord-015021-pol2qm74	3172	6	(	(	-LRB-
cord-015021-pol2qm74	3172	7	PRE	PRE	NNP
cord-015021-pol2qm74	3172	8	)	)	-RRB-
cord-015021-pol2qm74	3172	9	and	and	CC
cord-015021-pol2qm74	3172	10	on	on	IN
cord-015021-pol2qm74	3172	11	the	the	DT
cord-015021-pol2qm74	3172	12	1st	1st	JJ
cord-015021-pol2qm74	3172	13	and	and	CC
cord-015021-pol2qm74	3172	14	7th	7th	JJ
cord-015021-pol2qm74	3172	15	postoperative	postoperative	JJ
cord-015021-pol2qm74	3172	16	day(lEO	day(lEO	''
cord-015021-pol2qm74	3172	17	,	,	,
cord-015021-pol2qm74	3172	18	7PO	7PO	NNP
cord-015021-pol2qm74	3172	19	)	)	-RRB-
cord-015021-pol2qm74	3172	20	:	:	:
cord-015021-pol2qm74	3172	21	percentages	percentage	NNS
cord-015021-pol2qm74	3172	22	of	of	IN
cord-015021-pol2qm74	3172	23	CD19	CD19	NNP
cord-015021-pol2qm74	3172	24	,	,	,
cord-015021-pol2qm74	3172	25	CD5	CD5	NNP
cord-015021-pol2qm74	3172	26	,	,	,
cord-015021-pol2qm74	3172	27	CD4	CD4	NNP
cord-015021-pol2qm74	3172	28	,	,	,
cord-015021-pol2qm74	3172	29	CD8	CD8	NNP
cord-015021-pol2qm74	3172	30	and	and	CC
cord-015021-pol2qm74	3172	31	CD16	CD16	NNP
cord-015021-pol2qm74	3172	32	cells	cell	NNS
cord-015021-pol2qm74	3172	33	we	-PRON-	PRP
cord-015021-pol2qm74	3172	34	measured	measure	VBN
cord-015021-pol2qm74	3172	35	by	by	IN
cord-015021-pol2qm74	3172	36	means	mean	NNS
cord-015021-pol2qm74	3172	37	of	of	IN
cord-015021-pol2qm74	3172	38	flow	flow	NN
cord-015021-pol2qm74	3172	39	cytometry	cytometry	NN
cord-015021-pol2qm74	3172	40	using	use	VBG
cord-015021-pol2qm74	3172	41	MoAb	MoAb	NNP
cord-015021-pol2qm74	3172	42	.	.	.
cord-015021-pol2qm74	3173	1	and	and	CC
cord-015021-pol2qm74	3173	2	levels	level	NNS
cord-015021-pol2qm74	3173	3	of	of	IN
cord-015021-pol2qm74	3173	4	IL-1	IL-1	NNP
cord-015021-pol2qm74	3173	5	,	,	,
cord-015021-pol2qm74	3173	6	IL-4	IL-4	NNP
cord-015021-pol2qm74	3173	7	,	,	,
cord-015021-pol2qm74	3173	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	3173	9	and	and	CC
cord-015021-pol2qm74	3173	10	TNF	TNF	NNP
cord-015021-pol2qm74	3173	11	"	"	''
cord-015021-pol2qm74	3173	12	in	in	IN
cord-015021-pol2qm74	3173	13	vivo	vivo	NN
cord-015021-pol2qm74	3173	14	"	"	''
cord-015021-pol2qm74	3173	15	by	by	IN
cord-015021-pol2qm74	3173	16	ELISA	ELISA	NNP
cord-015021-pol2qm74	3173	17	using	use	VBG
cord-015021-pol2qm74	3173	18	MoAb	MoAb	NNP
cord-015021-pol2qm74	3173	19	.	.	.
cord-015021-pol2qm74	3174	1	RESULTS	result	NNS
cord-015021-pol2qm74	3174	2	:	:	:
cord-015021-pol2qm74	3175	1	ERE	ERE	NNP
cord-015021-pol2qm74	3175	2	:	:	:
cord-015021-pol2qm74	3176	1	CD16	CD16	NNP
cord-015021-pol2qm74	3176	2	%	%	NN
cord-015021-pol2qm74	3176	3	was	be	VBD
cord-015021-pol2qm74	3176	4	5.3_+3	5.3_+3	CD
cord-015021-pol2qm74	3176	5	in	in	IN
cord-015021-pol2qm74	3176	6	Gr	Gr	NNP
cord-015021-pol2qm74	3176	7	.	.	.
cord-015021-pol2qm74	3177	1	A	a	NN
cord-015021-pol2qm74	3177	2	and	and	CC
cord-015021-pol2qm74	3177	3	7	7	CD
cord-015021-pol2qm74	3177	4	.	.	NN
cord-015021-pol2qm74	3177	5	5	5	CD
cord-015021-pol2qm74	3177	6	 	 	_SP
cord-015021-pol2qm74	3178	1	Objectives	objective	NNS
cord-015021-pol2qm74	3178	2	of	of	IN
cord-015021-pol2qm74	3178	3	the	the	DT
cord-015021-pol2qm74	3178	4	study	study	NN
cord-015021-pol2qm74	3178	5	.	.	.
cord-015021-pol2qm74	3179	1	After	after	IN
cord-015021-pol2qm74	3179	2	surgery	surgery	NN
cord-015021-pol2qm74	3179	3	for	for	IN
cord-015021-pol2qm74	3179	4	esophageal	esophageal	JJ
cord-015021-pol2qm74	3179	5	cancer	cancer	NN
cord-015021-pol2qm74	3179	6	multiple	multiple	JJ
cord-015021-pol2qm74	3179	7	organ	organ	NN
cord-015021-pol2qm74	3179	8	damage	damage	NN
cord-015021-pol2qm74	3179	9	has	have	VBZ
cord-015021-pol2qm74	3179	10	been	be	VBN
cord-015021-pol2qm74	3179	11	reported	report	VBN
cord-015021-pol2qm74	3179	12	to	to	TO
cord-015021-pol2qm74	3179	13	be	be	VB
cord-015021-pol2qm74	3179	14	caused	cause	VBN
cord-015021-pol2qm74	3179	15	by	by	IN
cord-015021-pol2qm74	3179	16	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	3179	17	leukocyte	leukocyte	NN
cord-015021-pol2qm74	3179	18	(	(	-LRB-
cord-015021-pol2qm74	3179	19	PMN)-mediated	pmn)-mediate	VBN
cord-015021-pol2qm74	3179	20	injury	injury	NN
cord-015021-pol2qm74	3179	21	.	.	.
cord-015021-pol2qm74	3180	1	We	-PRON-	PRP
cord-015021-pol2qm74	3180	2	measured	measure	VBD
cord-015021-pol2qm74	3180	3	serum	serum	NN
cord-015021-pol2qm74	3180	4	granulocyte	granulocyte	NN
cord-015021-pol2qm74	3180	5	colony	colony	NN
cord-015021-pol2qm74	3180	6	-	-	HYPH
cord-015021-pol2qm74	3180	7	stimulating	stimulate	VBG
cord-015021-pol2qm74	3180	8	factor	factor	NN
cord-015021-pol2qm74	3180	9	(	(	-LRB-
cord-015021-pol2qm74	3180	10	G	G	NNP
cord-015021-pol2qm74	3180	11	-	-	HYPH
cord-015021-pol2qm74	3180	12	CSF	CSF	NNP
cord-015021-pol2qm74	3180	13	)	)	-RRB-
cord-015021-pol2qm74	3180	14	and	and	CC
cord-015021-pol2qm74	3180	15	interleukin	interleukin	NN
cord-015021-pol2qm74	3180	16	8	8	CD
cord-015021-pol2qm74	3180	17	(	(	-LRB-
cord-015021-pol2qm74	3180	18	IL-8	il-8	NN
cord-015021-pol2qm74	3180	19	)	)	-RRB-
cord-015021-pol2qm74	3180	20	levels	level	NNS
cord-015021-pol2qm74	3180	21	to	to	TO
cord-015021-pol2qm74	3180	22	determine	determine	VB
cord-015021-pol2qm74	3180	23	a	a	DT
cord-015021-pol2qm74	3180	24	role	role	NN
cord-015021-pol2qm74	3180	25	of	of	IN
cord-015021-pol2qm74	3180	26	G	G	NNP
cord-015021-pol2qm74	3180	27	-	-	HYPH
cord-015021-pol2qm74	3180	28	CSF	CSF	NNP
cord-015021-pol2qm74	3180	29	and	and	CC
cord-015021-pol2qm74	3180	30	IL-8	IL-8	NNP
cord-015021-pol2qm74	3180	31	in	in	IN
cord-015021-pol2qm74	3180	32	PMN	PMN	NNP
cord-015021-pol2qm74	3180	33	function	function	NN
cord-015021-pol2qm74	3180	34	after	after	IN
cord-015021-pol2qm74	3180	35	surgery	surgery	NN
cord-015021-pol2qm74	3180	36	for	for	IN
cord-015021-pol2qm74	3180	37	esophageal	esophageal	JJ
cord-015021-pol2qm74	3180	38	cancer	cancer	NN
cord-015021-pol2qm74	3180	39	.	.	.
cord-015021-pol2qm74	3181	1	Materials	material	NNS
cord-015021-pol2qm74	3181	2	and	and	CC
cord-015021-pol2qm74	3181	3	Methods	method	NNS
cord-015021-pol2qm74	3181	4	.	.	.
cord-015021-pol2qm74	3182	1	Peripheral	Peripheral	NNP
cord-015021-pol2qm74	3182	2	PMN	PMN	NNP
cord-015021-pol2qm74	3182	3	counts	count	VBZ
cord-015021-pol2qm74	3182	4	,	,	,
cord-015021-pol2qm74	3182	5	peripheral	peripheral	JJ
cord-015021-pol2qm74	3182	6	PMN	PMN	NNP
cord-015021-pol2qm74	3182	7	chemiluminescence	chemiluminescence	NN
cord-015021-pol2qm74	3182	8	,	,	,
cord-015021-pol2qm74	3182	9	serum	serum	NN
cord-015021-pol2qm74	3182	10	G	G	NNP
cord-015021-pol2qm74	3182	11	-	-	HYPH
cord-015021-pol2qm74	3182	12	CSF	csf	NN
cord-015021-pol2qm74	3182	13	levels	level	NNS
cord-015021-pol2qm74	3182	14	,	,	,
cord-015021-pol2qm74	3182	15	and	and	CC
cord-015021-pol2qm74	3182	16	serum	serum	NN
cord-015021-pol2qm74	3182	17	IL-8	il-8	NN
cord-015021-pol2qm74	3182	18	levels	level	NNS
cord-015021-pol2qm74	3182	19	were	be	VBD
cord-015021-pol2qm74	3182	20	measured	measure	VBN
cord-015021-pol2qm74	3182	21	before	before	RB
cord-015021-pol2qm74	3182	22	and	and	CC
cord-015021-pol2qm74	3182	23	after	after	IN
cord-015021-pol2qm74	3182	24	surgery	surgery	NN
cord-015021-pol2qm74	3182	25	in	in	IN
cord-015021-pol2qm74	3182	26	12	12	CD
cord-015021-pol2qm74	3182	27	patients	patient	NNS
cord-015021-pol2qm74	3182	28	with	with	IN
cord-015021-pol2qm74	3182	29	esophageal	esophageal	JJ
cord-015021-pol2qm74	3182	30	cancer	cancer	NN
cord-015021-pol2qm74	3182	31	(	(	-LRB-
cord-015021-pol2qm74	3182	32	EC	EC	NNP
cord-015021-pol2qm74	3182	33	)	)	-RRB-
cord-015021-pol2qm74	3182	34	,	,	,
cord-015021-pol2qm74	3182	35	and	and	CC
cord-015021-pol2qm74	3182	36	12	12	CD
cord-015021-pol2qm74	3182	37	patients	patient	NNS
cord-015021-pol2qm74	3182	38	of	of	IN
cord-015021-pol2qm74	3182	39	gastric	gastric	JJ
cord-015021-pol2qm74	3182	40	cancer	cancer	NN
cord-015021-pol2qm74	3182	41	(	(	-LRB-
cord-015021-pol2qm74	3182	42	GC	GC	NNP
cord-015021-pol2qm74	3182	43	)	)	-RRB-
cord-015021-pol2qm74	3182	44	.	.	.
cord-015021-pol2qm74	3183	1	Esophagectomy	Esophagectomy	NNP
cord-015021-pol2qm74	3183	2	with	with	IN
cord-015021-pol2qm74	3183	3	thoracotomy	thoracotomy	NN
cord-015021-pol2qm74	3183	4	and	and	CC
cord-015021-pol2qm74	3183	5	laparotomy	laparotomy	NN
cord-015021-pol2qm74	3183	6	were	be	VBD
cord-015021-pol2qm74	3183	7	performed	perform	VBN
cord-015021-pol2qm74	3183	8	for	for	IN
cord-015021-pol2qm74	3183	9	patients	patient	NNS
cord-015021-pol2qm74	3183	10	with	with	IN
cord-015021-pol2qm74	3183	11	EC	EC	NNP
cord-015021-pol2qm74	3183	12	,	,	,
cord-015021-pol2qm74	3183	13	while	while	IN
cord-015021-pol2qm74	3183	14	subtotal	subtotal	NN
cord-015021-pol2qm74	3183	15	gastrectomy	gastrectomy	NN
cord-015021-pol2qm74	3183	16	with	with	IN
cord-015021-pol2qm74	3183	17	laparotomy	laparotomy	NN
cord-015021-pol2qm74	3183	18	were	be	VBD
cord-015021-pol2qm74	3183	19	performed	perform	VBN
cord-015021-pol2qm74	3183	20	for	for	IN
cord-015021-pol2qm74	3183	21	patients	patient	NNS
cord-015021-pol2qm74	3183	22	with	with	IN
cord-015021-pol2qm74	3183	23	GC	GC	NNP
cord-015021-pol2qm74	3183	24	.	.	.
cord-015021-pol2qm74	3184	1	Results	result	NNS
cord-015021-pol2qm74	3184	2	.	.	.
cord-015021-pol2qm74	3185	1	Peripheral	Peripheral	NNP
cord-015021-pol2qm74	3185	2	PMN	PMN	NNP
cord-015021-pol2qm74	3185	3	counts	count	VBZ
cord-015021-pol2qm74	3185	4	(	(	-LRB-
cord-015021-pol2qm74	3185	5	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	3185	6	)	)	-RRB-
cord-015021-pol2qm74	3185	7	and	and	CC
cord-015021-pol2qm74	3185	8	peripheral	peripheral	JJ
cord-015021-pol2qm74	3185	9	PMN	PMN	NNP
cord-015021-pol2qm74	3185	10	chemiluminescence	chemiluminescence	NN
cord-015021-pol2qm74	3185	11	(	(	-LRB-
cord-015021-pol2qm74	3185	12	p<0.05	p<0.05	CD
cord-015021-pol2qm74	3185	13	)	)	-RRB-
cord-015021-pol2qm74	3185	14	of	of	IN
cord-015021-pol2qm74	3185	15	patients	patient	NNS
cord-015021-pol2qm74	3185	16	with	with	IN
cord-015021-pol2qm74	3185	17	EC	EC	NNP
cord-015021-pol2qm74	3185	18	were	be	VBD
cord-015021-pol2qm74	3185	19	significantly	significantly	RB
cord-015021-pol2qm74	3185	20	decreased	decrease	VBN
cord-015021-pol2qm74	3185	21	compared	compare	VBN
cord-015021-pol2qm74	3185	22	to	to	IN
cord-015021-pol2qm74	3185	23	those	those	DT
cord-015021-pol2qm74	3185	24	of	of	IN
cord-015021-pol2qm74	3185	25	patients	patient	NNS
cord-015021-pol2qm74	3185	26	with	with	IN
cord-015021-pol2qm74	3185	27	GC	GC	NNP
cord-015021-pol2qm74	3185	28	at	at	IN
cord-015021-pol2qm74	3185	29	4	4	CD
cord-015021-pol2qm74	3185	30	and	and	CC
cord-015021-pol2qm74	3185	31	8	8	CD
cord-015021-pol2qm74	3185	32	hours	hour	NNS
cord-015021-pol2qm74	3185	33	after	after	IN
cord-015021-pol2qm74	3185	34	surgery	surgery	NN
cord-015021-pol2qm74	3185	35	.	.	.
cord-015021-pol2qm74	3186	1	Serum	serum	NN
cord-015021-pol2qm74	3186	2	G	G	NNP
cord-015021-pol2qm74	3186	3	-	-	HYPH
cord-015021-pol2qm74	3186	4	CSF	csf	NN
cord-015021-pol2qm74	3186	5	levels	level	NNS
cord-015021-pol2qm74	3186	6	of	of	IN
cord-015021-pol2qm74	3186	7	patients	patient	NNS
cord-015021-pol2qm74	3186	8	with	with	IN
cord-015021-pol2qm74	3186	9	EC	EC	NNP
cord-015021-pol2qm74	3186	10	were	be	VBD
cord-015021-pol2qm74	3186	11	significantly	significantly	RB
cord-015021-pol2qm74	3186	12	(	(	-LRB-
cord-015021-pol2qm74	3186	13	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	3186	14	)	)	-RRB-
cord-015021-pol2qm74	3186	15	increased	increase	VBD
cord-015021-pol2qm74	3186	16	compared	compare	VBN
cord-015021-pol2qm74	3186	17	to	to	IN
cord-015021-pol2qm74	3186	18	those	those	DT
cord-015021-pol2qm74	3186	19	of	of	IN
cord-015021-pol2qm74	3186	20	patients	patient	NNS
cord-015021-pol2qm74	3186	21	with	with	IN
cord-015021-pol2qm74	3186	22	GC	GC	NNP
cord-015021-pol2qm74	3186	23	at	at	IN
cord-015021-pol2qm74	3186	24	4	4	CD
cord-015021-pol2qm74	3186	25	and	and	CC
cord-015021-pol2qm74	3186	26	8	8	CD
cord-015021-pol2qm74	3186	27	hours	hour	NNS
cord-015021-pol2qm74	3186	28	after	after	IN
cord-015021-pol2qm74	3186	29	surgery	surgery	NN
cord-015021-pol2qm74	3186	30	.	.	.
cord-015021-pol2qm74	3187	1	Serum	serum	NN
cord-015021-pol2qm74	3187	2	IL-8	il-8	NN
cord-015021-pol2qm74	3187	3	levels	level	NNS
cord-015021-pol2qm74	3187	4	of	of	IN
cord-015021-pol2qm74	3187	5	patients	patient	NNS
cord-015021-pol2qm74	3187	6	with	with	IN
cord-015021-pol2qm74	3187	7	EC	EC	NNP
cord-015021-pol2qm74	3187	8	were	be	VBD
cord-015021-pol2qm74	3187	9	significantly	significantly	RB
cord-015021-pol2qm74	3187	10	(	(	-LRB-
cord-015021-pol2qm74	3187	11	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	3187	12	)	)	-RRB-
cord-015021-pol2qm74	3187	13	increased	increase	VBD
cord-015021-pol2qm74	3187	14	compared	compare	VBN
cord-015021-pol2qm74	3187	15	to	to	IN
cord-015021-pol2qm74	3187	16	those	those	DT
cord-015021-pol2qm74	3187	17	of	of	IN
cord-015021-pol2qm74	3187	18	patients	patient	NNS
cord-015021-pol2qm74	3187	19	with	with	IN
cord-015021-pol2qm74	3187	20	GC	GC	NNP
cord-015021-pol2qm74	3187	21	at	at	IN
cord-015021-pol2qm74	3187	22	4	4	CD
cord-015021-pol2qm74	3187	23	,	,	,
cord-015021-pol2qm74	3187	24	8	8	CD
cord-015021-pol2qm74	3187	25	and	and	CC
cord-015021-pol2qm74	3187	26	24	24	CD
cord-015021-pol2qm74	3187	27	hours	hour	NNS
cord-015021-pol2qm74	3187	28	after	after	IN
cord-015021-pol2qm74	3187	29	surgery	surgery	NN
cord-015021-pol2qm74	3187	30	.	.	.
cord-015021-pol2qm74	3188	1	Significant	significant	JJ
cord-015021-pol2qm74	3188	2	inverse	inverse	JJ
cord-015021-pol2qm74	3188	3	correlations	correlation	NNS
cord-015021-pol2qm74	3188	4	(	(	-LRB-
cord-015021-pol2qm74	3188	5	p<0.0l	p<0.0l	NNP
cord-015021-pol2qm74	3188	6	)	)	-RRB-
cord-015021-pol2qm74	3188	7	between	between	IN
cord-015021-pol2qm74	3188	8	peripheral	peripheral	JJ
cord-015021-pol2qm74	3188	9	PMN	PMN	NNP
cord-015021-pol2qm74	3188	10	count	count	NN
cord-015021-pol2qm74	3188	11	and	and	CC
cord-015021-pol2qm74	3188	12	serum	serum	NN
cord-015021-pol2qm74	3188	13	G	G	NNP
cord-015021-pol2qm74	3188	14	-	-	HYPH
cord-015021-pol2qm74	3188	15	CSF	CSF	NNP
cord-015021-pol2qm74	3188	16	and	and	CC
cord-015021-pol2qm74	3188	17	IL-8	IL-8	NNP
cord-015021-pol2qm74	3188	18	levels	level	NNS
cord-015021-pol2qm74	3188	19	were	be	VBD
cord-015021-pol2qm74	3188	20	seen	see	VBN
cord-015021-pol2qm74	3188	21	at	at	IN
cord-015021-pol2qm74	3188	22	4	4	CD
cord-015021-pol2qm74	3188	23	hours	hour	NNS
cord-015021-pol2qm74	3188	24	after	after	IN
cord-015021-pol2qm74	3188	25	surgery	surgery	NN
cord-015021-pol2qm74	3188	26	.	.	.
cord-015021-pol2qm74	3189	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	3189	2	.	.	.
cord-015021-pol2qm74	3190	1	These	these	DT
cord-015021-pol2qm74	3190	2	results	result	NNS
cord-015021-pol2qm74	3190	3	suggest	suggest	VBP
cord-015021-pol2qm74	3190	4	that	that	IN
cord-015021-pol2qm74	3190	5	many	many	JJ
cord-015021-pol2qm74	3190	6	circulating	circulate	VBG
cord-015021-pol2qm74	3190	7	PMNs	pmn	NNS
cord-015021-pol2qm74	3190	8	,	,	,
cord-015021-pol2qm74	3190	9	which	which	WDT
cord-015021-pol2qm74	3190	10	are	be	VBP
cord-015021-pol2qm74	3190	11	excessively	excessively	RB
cord-015021-pol2qm74	3190	12	activated	activate	VBN
cord-015021-pol2qm74	3190	13	by	by	IN
cord-015021-pol2qm74	3190	14	G	G	NNP
cord-015021-pol2qm74	3190	15	-	-	HYPH
cord-015021-pol2qm74	3190	16	CSF	CSF	NNP
cord-015021-pol2qm74	3190	17	and	and	CC
cord-015021-pol2qm74	3190	18	IL-8	IL-8	NNP
cord-015021-pol2qm74	3190	19	,	,	,
cord-015021-pol2qm74	3190	20	may	may	MD
cord-015021-pol2qm74	3190	21	adhere	adhere	VB
cord-015021-pol2qm74	3190	22	to	to	IN
cord-015021-pol2qm74	3190	23	the	the	DT
cord-015021-pol2qm74	3190	24	endotherial	endotherial	JJ
cord-015021-pol2qm74	3190	25	cells	cell	NNS
cord-015021-pol2qm74	3190	26	and	and	CC
cord-015021-pol2qm74	3190	27	then	then	RB
cord-015021-pol2qm74	3190	28	migrate	migrate	VB
cord-015021-pol2qm74	3190	29	into	into	IN
cord-015021-pol2qm74	3190	30	the	the	DT
cord-015021-pol2qm74	3190	31	tissues	tissue	NNS
cord-015021-pol2qm74	3190	32	,	,	,
cord-015021-pol2qm74	3190	33	and	and	CC
cord-015021-pol2qm74	3190	34	cause	cause	VB
cord-015021-pol2qm74	3190	35	multiple	multiple	JJ
cord-015021-pol2qm74	3190	36	organ	organ	NN
cord-015021-pol2qm74	3190	37	damage	damage	NN
cord-015021-pol2qm74	3190	38	after	after	IN
cord-015021-pol2qm74	3190	39	surgery	surgery	NN
cord-015021-pol2qm74	3190	40	for	for	IN
cord-015021-pol2qm74	3190	41	esophageal	esophageal	JJ
cord-015021-pol2qm74	3190	42	cancer	cancer	NN
cord-015021-pol2qm74	3190	43	.	.	.
cord-015021-pol2qm74	3191	1	ImmunNogical	ImmunNogical	NNP
cord-015021-pol2qm74	3191	2	changes	change	NNS
cord-015021-pol2qm74	3191	3	in	in	IN
cord-015021-pol2qm74	3191	4	patients	patient	NNS
cord-015021-pol2qm74	3191	5	with	with	IN
cord-015021-pol2qm74	3191	6	severe	severe	JJ
cord-015021-pol2qm74	3191	7	brain	brain	NN
cord-015021-pol2qm74	3191	8	trauma	trauma	NN
cord-015021-pol2qm74	3191	9	receive	receive	VBP
cord-015021-pol2qm74	3191	10	increasing	increase	VBG
cord-015021-pol2qm74	3191	11	attention	attention	NN
cord-015021-pol2qm74	3191	12	since	since	IN
cord-015021-pol2qm74	3191	13	morbidity	morbidity	NN
cord-015021-pol2qm74	3191	14	and	and	CC
cord-015021-pol2qm74	3191	15	mortality	mortality	NN
cord-015021-pol2qm74	3191	16	ere	ere	VBP
cord-015021-pol2qm74	3191	17	still	still	RB
cord-015021-pol2qm74	3191	18	high	high	JJ
cord-015021-pol2qm74	3191	19	.	.	.
cord-015021-pol2qm74	3192	1	Interleukin-6	Interleukin-6	NNP
cord-015021-pol2qm74	3193	1	(	(	-LRB-
cord-015021-pol2qm74	3193	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3193	3	)	)	-RRB-
cord-015021-pol2qm74	3193	4	was	be	VBD
cord-015021-pol2qm74	3193	5	previously	previously	RB
cord-015021-pol2qm74	3193	6	detected	detect	VBN
cord-015021-pol2qm74	3193	7	in	in	IN
cord-015021-pol2qm74	3193	8	the	the	DT
cord-015021-pol2qm74	3193	9	cerebrospinal	cerebrospinal	JJ
cord-015021-pol2qm74	3193	10	fluid	fluid	NN
cord-015021-pol2qm74	3193	11	(	(	-LRB-
cord-015021-pol2qm74	3193	12	CSF	CSF	NNP
cord-015021-pol2qm74	3193	13	)	)	-RRB-
cord-015021-pol2qm74	3193	14	during	during	IN
cord-015021-pol2qm74	3193	15	different	different	JJ
cord-015021-pol2qm74	3193	16	pathologies	pathology	NNS
cord-015021-pol2qm74	3193	17	of	of	IN
cord-015021-pol2qm74	3193	18	the	the	DT
cord-015021-pol2qm74	3193	19	nervous	nervous	JJ
cord-015021-pol2qm74	3193	20	system	system	NN
cord-015021-pol2qm74	3193	21	(	(	-LRB-
cord-015021-pol2qm74	3193	22	1	1	CD
cord-015021-pol2qm74	3193	23	,	,	,
cord-015021-pol2qm74	3193	24	2	2	CD
cord-015021-pol2qm74	3193	25	,	,	,
cord-015021-pol2qm74	3193	26	3	3	CD
cord-015021-pol2qm74	3193	27	)	)	-RRB-
cord-015021-pol2qm74	3193	28	.	.	.
cord-015021-pol2qm74	3194	1	in	in	IN
cord-015021-pol2qm74	3194	2	our	-PRON-	PRP$
cord-015021-pol2qm74	3194	3	study	study	NN
cord-015021-pol2qm74	3194	4	we	-PRON-	PRP
cord-015021-pol2qm74	3194	5	monitored	monitor	VBD
cord-015021-pol2qm74	3194	6	iL-6	il-6	DT
cord-015021-pol2qm74	3194	7	and	and	CC
cord-015021-pol2qm74	3194	8	Nerve	Nerve	NNP
cord-015021-pol2qm74	3194	9	Growth	Growth	NNP
cord-015021-pol2qm74	3194	10	Factor	factor	NN
cord-015021-pol2qm74	3194	11	(	(	-LRB-
cord-015021-pol2qm74	3194	12	NGF	NGF	NNP
cord-015021-pol2qm74	3194	13	)	)	-RRB-
cord-015021-pol2qm74	3194	14	production	production	NN
cord-015021-pol2qm74	3194	15	in	in	IN
cord-015021-pol2qm74	3194	16	the	the	DT
cord-015021-pol2qm74	3194	17	CSF	CSF	NNP
cord-015021-pol2qm74	3194	18	after	after	IN
cord-015021-pol2qm74	3194	19	human	human	JJ
cord-015021-pol2qm74	3194	20	brain	brain	NN
cord-015021-pol2qm74	3194	21	trauma	trauma	NN
cord-015021-pol2qm74	3194	22	.	.	.
cord-015021-pol2qm74	3195	1	Since	since	IN
cord-015021-pol2qm74	3195	2	astrocytes	astrocyte	NNS
cord-015021-pol2qm74	3195	3	within	within	IN
cord-015021-pol2qm74	3195	4	the	the	DT
cord-015021-pol2qm74	3195	5	brain	brain	NN
cord-015021-pol2qm74	3195	6	constitute	constitute	VBP
cord-015021-pol2qm74	3195	7	one	one	CD
cord-015021-pol2qm74	3195	8	of	of	IN
cord-015021-pol2qm74	3195	9	the	the	DT
cord-015021-pol2qm74	3195	10	major	major	JJ
cord-015021-pol2qm74	3195	11	cell	cell	NN
cord-015021-pol2qm74	3195	12	type	type	NN
cord-015021-pol2qm74	3195	13	contributing	contribute	VBG
cord-015021-pol2qm74	3195	14	to	to	IN
cord-015021-pol2qm74	3195	15	the	the	DT
cord-015021-pol2qm74	3195	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3195	17	response	response	NN
cord-015021-pol2qm74	3195	18	through	through	IN
cord-015021-pol2qm74	3195	19	the	the	DT
cord-015021-pol2qm74	3195	20	release	release	NN
cord-015021-pol2qm74	3195	21	of	of	IN
cord-015021-pol2qm74	3195	22	cytokines	cytokine	NNS
cord-015021-pol2qm74	3195	23	and	and	CC
cord-015021-pol2qm74	3195	24	other	other	JJ
cord-015021-pol2qm74	3195	25	factors	factor	NNS
cord-015021-pol2qm74	3195	26	after	after	IN
cord-015021-pol2qm74	3195	27	injury	injury	NN
cord-015021-pol2qm74	3195	28	,	,	,
cord-015021-pol2qm74	3195	29	we	-PRON-	PRP
cord-015021-pol2qm74	3195	30	investigated	investigate	VBD
cord-015021-pol2qm74	3195	31	the	the	DT
cord-015021-pol2qm74	3195	32	functional	functional	JJ
cord-015021-pol2qm74	3195	33	relationship	relationship	NN
cord-015021-pol2qm74	3195	34	of	of	IN
cord-015021-pol2qm74	3195	35	IL-6	IL-6	NNP
cord-015021-pol2qm74	3195	36	and	and	CC
cord-015021-pol2qm74	3195	37	NGF	NGF	NNP
cord-015021-pol2qm74	3195	38	on	on	IN
cord-015021-pol2qm74	3195	39	a	a	DT
cord-015021-pol2qm74	3195	40	single	single	JJ
cord-015021-pol2qm74	3195	41	cell	cell	NN
cord-015021-pol2qm74	3195	42	niveau	niveau	NN
cord-015021-pol2qm74	3195	43	using	use	VBG
cord-015021-pol2qm74	3195	44	cultured	cultured	JJ
cord-015021-pol2qm74	3195	45	astrocytes	astrocyte	NNS
cord-015021-pol2qm74	3195	46	.	.	.
cord-015021-pol2qm74	3196	1	Methods	Methods	NNPS
cord-015021-pol2qm74	3196	2	CSF	CSF	NNP
cord-015021-pol2qm74	3196	3	was	be	VBD
cord-015021-pol2qm74	3196	4	obtained	obtain	VBN
cord-015021-pol2qm74	3196	5	from	from	IN
cord-015021-pol2qm74	3196	6	patients	patient	NNS
cord-015021-pol2qm74	3196	7	with	with	IN
cord-015021-pol2qm74	3196	8	severe	severe	JJ
cord-015021-pol2qm74	3196	9	brain	brain	NN
cord-015021-pol2qm74	3196	10	injury	injury	NN
cord-015021-pol2qm74	3197	1	(	(	-LRB-
cord-015021-pol2qm74	3197	2	Glasgow	Glasgow	NNP
cord-015021-pol2qm74	3197	3	Coma	Coma	NNP
cord-015021-pol2qm74	3197	4	Score	Score	NNP
cord-015021-pol2qm74	3197	5	(	(	-LRB-
cord-015021-pol2qm74	3197	6	GCS	GCS	NNP
cord-015021-pol2qm74	3197	7	)	)	-RRB-
cord-015021-pol2qm74	3198	1	<	<	NNP
cord-015021-pol2qm74	3198	2	8	8	CD
cord-015021-pol2qm74	3198	3	and	and	CC
cord-015021-pol2qm74	3198	4	CT	CT	NNP
cord-015021-pol2qm74	3198	5	abnormatities	abnormatitie	NNS
cord-015021-pol2qm74	3198	6	or	or	CC
cord-015021-pol2qm74	3199	1	GCS	GCS	NNP
cord-015021-pol2qm74	3199	2	<	<	XX
cord-015021-pol2qm74	3199	3	8	8	CD
cord-015021-pol2qm74	3199	4	over	over	IN
cord-015021-pol2qm74	3199	5	6	6	CD
cord-015021-pol2qm74	3199	6	hours	hour	NNS
cord-015021-pol2qm74	3199	7	)	)	-RRB-
cord-015021-pol2qm74	3200	1	after	after	IN
cord-015021-pol2qm74	3200	2	implantation	implantation	NN
cord-015021-pol2qm74	3200	3	of	of	IN
cord-015021-pol2qm74	3200	4	intraventricular	intraventricular	JJ
cord-015021-pol2qm74	3200	5	ICP	ICP	NNP
cord-015021-pol2qm74	3200	6	monitoring	monitor	VBG
cord-015021-pol2qm74	3200	7	device	device	NN
cord-015021-pol2qm74	3200	8	for	for	IN
cord-015021-pol2qm74	3200	9	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	3200	10	purpose	purpose	NN
cord-015021-pol2qm74	3200	11	and	and	CC
cord-015021-pol2qm74	3200	12	collected	collect	VBD
cord-015021-pol2qm74	3200	13	over	over	IN
cord-015021-pol2qm74	3200	14	24	24	CD
cord-015021-pol2qm74	3200	15	hours	hour	NNS
cord-015021-pol2qm74	3200	16	CSF	csf	NN
cord-015021-pol2qm74	3200	17	and	and	CC
cord-015021-pol2qm74	3200	18	serum	serum	NN
cord-015021-pol2qm74	3200	19	.	.	.
cord-015021-pol2qm74	3201	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3201	2	and	and	CC
cord-015021-pol2qm74	3201	3	NGF	NGF	NNP
cord-015021-pol2qm74	3201	4	were	be	VBD
cord-015021-pol2qm74	3201	5	assayed	assay	VBN
cord-015021-pol2qm74	3201	6	by	by	IN
cord-015021-pol2qm74	3201	7	ELISA	ELISA	NNP
cord-015021-pol2qm74	3201	8	.	.	.
cord-015021-pol2qm74	3202	1	Astrocytes	Astrocytes	NNP
cord-015021-pol2qm74	3202	2	were	be	VBD
cord-015021-pol2qm74	3202	3	isolated	isolate	VBN
cord-015021-pol2qm74	3202	4	from	from	IN
cord-015021-pol2qm74	3202	5	neonatal	neonatal	JJ
cord-015021-pol2qm74	3202	6	mouse	mouse	NN
cord-015021-pol2qm74	3202	7	brain	brain	NN
cord-015021-pol2qm74	3202	8	as	as	IN
cord-015021-pol2qm74	3202	9	described	describe	VBN
cord-015021-pol2qm74	3202	10	(	(	-LRB-
cord-015021-pol2qm74	3202	11	4	4	CD
cord-015021-pol2qm74	3202	12	)	)	-RRB-
cord-015021-pol2qm74	3202	13	.	.	.
cord-015021-pol2qm74	3203	1	NGF	NGF	NNP
cord-015021-pol2qm74	3203	2	production	production	NN
cord-015021-pol2qm74	3203	3	by	by	IN
cord-015021-pol2qm74	3203	4	cultured	cultured	JJ
cord-015021-pol2qm74	3203	5	astrocytes	astrocyte	NNS
cord-015021-pol2qm74	3203	6	was	be	VBD
cord-015021-pol2qm74	3203	7	measured	measure	VBN
cord-015021-pol2qm74	3203	8	by	by	IN
cord-015021-pol2qm74	3203	9	ELISA	ELISA	NNP
cord-015021-pol2qm74	3203	10	in	in	IN
cord-015021-pol2qm74	3203	11	the	the	DT
cord-015021-pol2qm74	3203	12	presence	presence	NN
cord-015021-pol2qm74	3203	13	of	of	IN
cord-015021-pol2qm74	3203	14	CSF	CSF	NNP
cord-015021-pol2qm74	3203	15	,	,	,
cord-015021-pol2qm74	3203	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	3203	17	and	and	CC
cord-015021-pol2qm74	3203	18	IL-6	IL-6	NNP
cord-015021-pol2qm74	3203	19	antibody	antibody	NN
cord-015021-pol2qm74	3203	20	.	.	.
cord-015021-pol2qm74	3204	1	Astrocyte	Astrocyte	NNP
cord-015021-pol2qm74	3204	2	migration	migration	NN
cord-015021-pol2qm74	3204	3	was	be	VBD
cord-015021-pol2qm74	3204	4	tested	test	VBN
cord-015021-pol2qm74	3204	5	in	in	IN
cord-015021-pol2qm74	3204	6	a	a	DT
cord-015021-pol2qm74	3204	7	chemstaxis	chemstaxis	NNP
cord-015021-pol2qm74	3204	8	chamber	chamber	NN
cord-015021-pol2qm74	3204	9	.	.	.
cord-015021-pol2qm74	3205	1	Results	result	NNS
cord-015021-pol2qm74	3206	1	17	17	CD
cord-015021-pol2qm74	3206	2	head	head	NN
cord-015021-pol2qm74	3206	3	trauma	trauma	NN
cord-015021-pol2qm74	3206	4	patients	patient	NNS
cord-015021-pol2qm74	3206	5	were	be	VBD
cord-015021-pol2qm74	3206	6	included	include	VBN
cord-015021-pol2qm74	3206	7	in	in	IN
cord-015021-pol2qm74	3206	8	this	this	DT
cord-015021-pol2qm74	3206	9	study	study	NN
cord-015021-pol2qm74	3206	10	(	(	-LRB-
cord-015021-pol2qm74	3206	11	approved	approve	VBN
cord-015021-pol2qm74	3206	12	by	by	IN
cord-015021-pol2qm74	3206	13	the	the	DT
cord-015021-pol2qm74	3206	14	University	University	NNP
cord-015021-pol2qm74	3206	15	Hospital	Hospital	NNP
cord-015021-pol2qm74	3206	16	Medical	Medical	NNP
cord-015021-pol2qm74	3206	17	Ethics	Ethics	NNPS
cord-015021-pol2qm74	3206	18	Board	Board	NNP
cord-015021-pol2qm74	3206	19	)	)	-RRB-
cord-015021-pol2qm74	3206	20	and	and	CC
cord-015021-pol2qm74	3206	21	the	the	DT
cord-015021-pol2qm74	3206	22	CSF	CSF	NNP
cord-015021-pol2qm74	3206	23	was	be	VBD
cord-015021-pol2qm74	3206	24	obtained	obtain	VBN
cord-015021-pol2qm74	3206	25	through	through	IN
cord-015021-pol2qm74	3206	26	intraventricular	intraventricular	JJ
cord-015021-pol2qm74	3206	27	catheters	catheter	NNS
cord-015021-pol2qm74	3206	28	.	.	.
cord-015021-pol2qm74	3207	1	High	high	JJ
cord-015021-pol2qm74	3207	2	levels	level	NNS
cord-015021-pol2qm74	3207	3	of	of	IN
cord-015021-pol2qm74	3207	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	3207	5	were	be	VBD
cord-015021-pol2qm74	3207	6	detected	detect	VBN
cord-015021-pol2qm74	3207	7	in	in	IN
cord-015021-pol2qm74	3207	8	the	the	DT
cord-015021-pol2qm74	3207	9	CSF	csf	NN
cord-015021-pol2qm74	3207	10	of	of	IN
cord-015021-pol2qm74	3207	11	these	these	DT
cord-015021-pol2qm74	3207	12	patients	patient	NNS
cord-015021-pol2qm74	3207	13	when	when	WRB
cord-015021-pol2qm74	3207	14	compared	compare	VBN
cord-015021-pol2qm74	3207	15	to	to	IN
cord-015021-pol2qm74	3207	16	serum	serum	NN
cord-015021-pol2qm74	3207	17	during	during	IN
cord-015021-pol2qm74	3207	18	the	the	DT
cord-015021-pol2qm74	3207	19	first	first	JJ
cord-015021-pol2qm74	3207	20	days	day	NNS
cord-015021-pol2qm74	3207	21	after	after	IN
cord-015021-pol2qm74	3207	22	brain	brain	NN
cord-015021-pol2qm74	3207	23	trauma	trauma	NN
cord-015021-pol2qm74	3207	24	.	.	.
cord-015021-pol2qm74	3208	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	3208	2	NGF	NGF	NNP
cord-015021-pol2qm74	3208	3	could	could	MD
cord-015021-pol2qm74	3208	4	be	be	VB
cord-015021-pol2qm74	3208	5	found	find	VBN
cord-015021-pol2qm74	3208	6	inside	inside	IN
cord-015021-pol2qm74	3208	7	the	the	DT
cord-015021-pol2qm74	3208	8	intracerebral	intracerebral	NNP
cord-015021-pol2qm74	3208	9	compartment	compartment	NNP
cord-015021-pol2qm74	3208	10	.	.	.
cord-015021-pol2qm74	3209	1	CSF	csf	NN
cord-015021-pol2qm74	3209	2	containing	contain	VBG
cord-015021-pol2qm74	3209	3	high	high	JJ
cord-015021-pol2qm74	3209	4	levels	level	NNS
cord-015021-pol2qm74	3209	5	of	of	IN
cord-015021-pol2qm74	3209	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	3209	7	could	could	MD
cord-015021-pol2qm74	3209	8	stimulate	stimulate	VB
cord-015021-pol2qm74	3209	9	NGF	NGF	NNP
cord-015021-pol2qm74	3209	10	production	production	NN
cord-015021-pol2qm74	3209	11	in	in	IN
cord-015021-pol2qm74	3209	12	cultured	cultured	JJ
cord-015021-pol2qm74	3209	13	astrocytes	astrocyte	NNS
cord-015021-pol2qm74	3209	14	.	.	.
cord-015021-pol2qm74	3210	1	This	this	DT
cord-015021-pol2qm74	3210	2	effect	effect	NN
cord-015021-pol2qm74	3210	3	could	could	MD
cord-015021-pol2qm74	3210	4	be	be	VB
cord-015021-pol2qm74	3210	5	[	[	-LRB-
cord-015021-pol2qm74	3210	6	nhibited	nhibite	VBN
cord-015021-pol2qm74	3210	7	partially	partially	RB
cord-015021-pol2qm74	3210	8	by	by	IN
cord-015021-pol2qm74	3210	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	3210	10	antibodies	antibody	NNS
cord-015021-pol2qm74	3210	11	,	,	,
cord-015021-pol2qm74	3210	12	Purified	purify	VBN
cord-015021-pol2qm74	3210	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	3210	14	exposed	expose	VBN
cord-015021-pol2qm74	3210	15	to	to	IN
cord-015021-pol2qm74	3210	16	cultured	cultured	JJ
cord-015021-pol2qm74	3210	17	astrocytes	astrocyte	NNS
cord-015021-pol2qm74	3210	18	in	in	IN
cord-015021-pol2qm74	3210	19	vitro	vitro	FW
cord-015021-pol2qm74	3210	20	,	,	,
cord-015021-pol2qm74	3210	21	stimulated	stimulate	VBD
cord-015021-pol2qm74	3210	22	the	the	DT
cord-015021-pol2qm74	3210	23	migratory	migratory	JJ
cord-015021-pol2qm74	3210	24	activity	activity	NN
cord-015021-pol2qm74	3210	25	of	of	IN
cord-015021-pol2qm74	3210	26	these	these	DT
cord-015021-pol2qm74	3210	27	cells	cell	NNS
cord-015021-pol2qm74	3210	28	in	in	IN
cord-015021-pol2qm74	3210	29	a	a	DT
cord-015021-pol2qm74	3210	30	dose	dose	JJ
cord-015021-pol2qm74	3210	31	response	response	NN
cord-015021-pol2qm74	3210	32	fashion	fashion	NN
cord-015021-pol2qm74	3210	33	.	.	.
cord-015021-pol2qm74	3211	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3211	2	was	be	VBD
cord-015021-pol2qm74	3211	3	found	find	VBN
cord-015021-pol2qm74	3211	4	in	in	IN
cord-015021-pol2qm74	3211	5	the	the	DT
cord-015021-pol2qm74	3211	6	CSF	CSF	NNP
cord-015021-pol2qm74	3211	7	of	of	IN
cord-015021-pol2qm74	3211	8	brain	brain	NN
cord-015021-pol2qm74	3211	9	injured	injure	VBN
cord-015021-pol2qm74	3211	10	patients	patient	NNS
cord-015021-pol2qm74	3211	11	,	,	,
cord-015021-pol2qm74	3211	12	suggesting	suggest	VBG
cord-015021-pol2qm74	3211	13	a	a	DT
cord-015021-pol2qm74	3211	14	role	role	NN
cord-015021-pol2qm74	3211	15	for	for	IN
cord-015021-pol2qm74	3211	16	this	this	DT
cord-015021-pol2qm74	3211	17	cytokine	cytokine	NN
cord-015021-pol2qm74	3211	18	in	in	IN
cord-015021-pol2qm74	3211	19	the	the	DT
cord-015021-pol2qm74	3211	20	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	3211	21	of	of	IN
cord-015021-pol2qm74	3211	22	brain	brain	NN
cord-015021-pol2qm74	3211	23	injury	injury	NN
cord-015021-pol2qm74	3211	24	.	.	.
cord-015021-pol2qm74	3212	1	Since	since	IN
cord-015021-pol2qm74	3212	2	astrocytes	astrocyte	NNS
cord-015021-pol2qm74	3212	3	are	be	VBP
cord-015021-pol2qm74	3212	4	involved	involve	VBN
cord-015021-pol2qm74	3212	5	in	in	IN
cord-015021-pol2qm74	3212	6	maintaining	maintain	VBG
cord-015021-pol2qm74	3212	7	the	the	DT
cord-015021-pol2qm74	3212	8	homeostasis	homeostasis	NN
cord-015021-pol2qm74	3212	9	of	of	IN
cord-015021-pol2qm74	3212	10	the	the	DT
cord-015021-pol2qm74	3212	11	brain	brain	NN
cord-015021-pol2qm74	3212	12	,	,	,
cord-015021-pol2qm74	3212	13	we	-PRON-	PRP
cord-015021-pol2qm74	3212	14	further	further	RB
cord-015021-pol2qm74	3212	15	investigated	investigate	VBD
cord-015021-pol2qm74	3212	16	the	the	DT
cord-015021-pol2qm74	3212	17	possible	possible	JJ
cord-015021-pol2qm74	3212	18	role	role	NN
cord-015021-pol2qm74	3212	19	o1	o1	NNP
cord-015021-pol2qm74	3212	20	IL-6	IL-6	NNP
cord-015021-pol2qm74	3212	21	on	on	IN
cord-015021-pol2qm74	3212	22	astrocyte	astrocyte	NNP
cord-015021-pol2qm74	3212	23	functions	function	NNS
cord-015021-pol2qm74	3212	24	,	,	,
cord-015021-pol2qm74	3212	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	3212	26	promoted	promote	VBD
cord-015021-pol2qm74	3212	27	NGF	NGF	NNP
cord-015021-pol2qm74	3212	28	production	production	NN
cord-015021-pol2qm74	3212	29	in	in	IN
cord-015021-pol2qm74	3212	30	vivo	vivo	NN
cord-015021-pol2qm74	3212	31	and	and	CC
cord-015021-pol2qm74	3212	32	in	in	IN
cord-015021-pol2qm74	3212	33	vitro	vitro	FW
cord-015021-pol2qm74	3212	34	,	,	,
cord-015021-pol2qm74	3212	35	thus	thus	RB
cord-015021-pol2qm74	3212	36	contributing	contribute	VBG
cord-015021-pol2qm74	3212	37	to	to	IN
cord-015021-pol2qm74	3212	38	neuronal	neuronal	JJ
cord-015021-pol2qm74	3212	39	cell	cell	NN
cord-015021-pol2qm74	3212	40	survival	survival	NN
cord-015021-pol2qm74	3212	41	and	and	CC
cord-015021-pol2qm74	3212	42	regeneration	regeneration	NN
cord-015021-pol2qm74	3212	43	.	.	.
cord-015021-pol2qm74	3213	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	3213	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3213	3	stimulated	stimulate	VBD
cord-015021-pol2qm74	3213	4	astrocyte	astrocyte	NNP
cord-015021-pol2qm74	3213	5	migration	migration	NN
cord-015021-pol2qm74	3213	6	in	in	IN
cord-015021-pol2qm74	3213	7	a	a	DT
cord-015021-pol2qm74	3213	8	dose	dose	JJ
cord-015021-pol2qm74	3213	9	response	response	NN
cord-015021-pol2qm74	3213	10	fashion	fashion	NN
cord-015021-pol2qm74	3213	11	,	,	,
cord-015021-pol2qm74	3213	12	potentially	potentially	RB
cord-015021-pol2qm74	3213	13	contributing	contribute	VBG
cord-015021-pol2qm74	3213	14	to	to	IN
cord-015021-pol2qm74	3213	15	astrocytosis	astrocytosis	NN
cord-015021-pol2qm74	3213	16	following	follow	VBG
cord-015021-pol2qm74	3213	17	brain	brain	NN
cord-015021-pol2qm74	3213	18	injury	injury	NN
cord-015021-pol2qm74	3213	19	and	and	CC
cord-015021-pol2qm74	3213	20	inflammation	inflammation	NN
cord-015021-pol2qm74	3213	21	,	,	,
cord-015021-pol2qm74	3213	22	These	these	DT
cord-015021-pol2qm74	3213	23	results	result	NNS
cord-015021-pol2qm74	3213	24	show	show	VBP
cord-015021-pol2qm74	3213	25	that	that	IN
cord-015021-pol2qm74	3213	26	IL-6	IL-6	NNP
cord-015021-pol2qm74	3213	27	represents	represent	VBZ
cord-015021-pol2qm74	3213	28	a	a	DT
cord-015021-pol2qm74	3213	29	key	key	JJ
cord-015021-pol2qm74	3213	30	cytokine	cytokine	NN
cord-015021-pol2qm74	3213	31	in	in	IN
cord-015021-pol2qm74	3213	32	traumatic	traumatic	JJ
cord-015021-pol2qm74	3213	33	human	human	JJ
cord-015021-pol2qm74	3213	34	brain	brain	NN
cord-015021-pol2qm74	3213	35	injury	injury	NN
cord-015021-pol2qm74	3213	36	with	with	IN
cord-015021-pol2qm74	3213	37	possible	possible	JJ
cord-015021-pol2qm74	3213	38	systemic	systemic	JJ
cord-015021-pol2qm74	3213	39	effects	effect	NNS
cord-015021-pol2qm74	3213	40	,	,	,
cord-015021-pol2qm74	3213	41	which	which	WDT
cord-015021-pol2qm74	3213	42	are	be	VBP
cord-015021-pol2qm74	3213	43	at	at	IN
cord-015021-pol2qm74	3213	44	preserlt	preserlt	NNP
cord-015021-pol2qm74	3213	45	under	under	IN
cord-015021-pol2qm74	3213	46	investigation	investigation	NN
cord-015021-pol2qm74	3213	47	.	.	.
cord-015021-pol2qm74	3214	1	We	-PRON-	PRP
cord-015021-pol2qm74	3214	2	studied	study	VBD
cord-015021-pol2qm74	3214	3	a	a	DT
cord-015021-pol2qm74	3214	4	)	)	-RRB-
cord-015021-pol2qm74	3214	5	the	the	DT
cord-015021-pol2qm74	3214	6	role	role	NN
cord-015021-pol2qm74	3214	7	of	of	IN
cord-015021-pol2qm74	3214	8	TNF	TNF	NNP
cord-015021-pol2qm74	3214	9	and	and	CC
cord-015021-pol2qm74	3214	10	b	b	LS
cord-015021-pol2qm74	3214	11	)	)	-RRB-
cord-015021-pol2qm74	3214	12	the	the	DT
cord-015021-pol2qm74	3214	13	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	3214	14	effect	effect	NN
cord-015021-pol2qm74	3214	15	of	of	IN
cord-015021-pol2qm74	3214	16	a	a	DT
cord-015021-pol2qm74	3214	17	mab	mab	NN
cord-015021-pol2qm74	3214	18	to	to	IN
cord-015021-pol2qm74	3214	19	TNF	TNF	NNP
cord-015021-pol2qm74	3214	20	with	with	IN
cord-015021-pol2qm74	3214	21	regard	regard	NN
cord-015021-pol2qm74	3214	22	to	to	IN
cord-015021-pol2qm74	3214	23	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	3214	24	shock	shock	NN
cord-015021-pol2qm74	3214	25	(	(	-LRB-
cord-015021-pol2qm74	3214	26	HS	HS	NNP
cord-015021-pol2qm74	3214	27	)	)	-RRB-
cord-015021-pol2qm74	3214	28	related	relate	VBN
cord-015021-pol2qm74	3214	29	,	,	,
cord-015021-pol2qm74	3214	30	pathophysiologic	pathophysiologic	JJ
cord-015021-pol2qm74	3214	31	alterations	alteration	NNS
cord-015021-pol2qm74	3214	32	and	and	CC
cord-015021-pol2qm74	3214	33	mortality	mortality	NN
cord-015021-pol2qm74	3214	34	in	in	IN
cord-015021-pol2qm74	3214	35	rats	rat	NNS
cord-015021-pol2qm74	3214	36	.	.	.
cord-015021-pol2qm74	3215	1	Method	method	NN
cord-015021-pol2qm74	3215	2	:	:	:
cord-015021-pol2qm74	3216	1	A	a	DT
cord-015021-pol2qm74	3216	2	prolonged	prolonged	JJ
cord-015021-pol2qm74	3216	3	HS	hs	NN
cord-015021-pol2qm74	3216	4	was	be	VBD
cord-015021-pol2qm74	3216	5	induced	induce	VBN
cord-015021-pol2qm74	3216	6	by	by	IN
cord-015021-pol2qm74	3216	7	bleeding	bleed	VBG
cord-015021-pol2qm74	3216	8	to	to	IN
cord-015021-pol2qm74	3216	9	a	a	DT
cord-015021-pol2qm74	3216	10	blood	blood	NN
cord-015021-pol2qm74	3216	11	pressure	pressure	NN
cord-015021-pol2qm74	3216	12	of	of	IN
cord-015021-pol2qm74	3216	13	30	30	CD
cord-015021-pol2qm74	3216	14	-	-	SYM
cord-015021-pol2qm74	3216	15	35	35	CD
cord-015021-pol2qm74	3216	16	mmHg	mmHg	NNS
cord-015021-pol2qm74	3216	17	for	for	IN
cord-015021-pol2qm74	3216	18	180	180	CD
cord-015021-pol2qm74	3216	19	pin	pin	NN
cord-015021-pol2qm74	3216	20	followed	follow	VBN
cord-015021-pol2qm74	3216	21	by	by	IN
cord-015021-pol2qm74	3216	22	reinfusion	reinfusion	NN
cord-015021-pol2qm74	3216	23	of	of	IN
cord-015021-pol2qm74	3216	24	shed	shed	JJ
cord-015021-pol2qm74	3216	25	blood	blood	NN
cord-015021-pol2qm74	3216	26	(	(	-LRB-
cord-015021-pol2qm74	3216	27	SB	SB	NNP
cord-015021-pol2qm74	3216	28	)	)	-RRB-
cord-015021-pol2qm74	3216	29	and	and	CC
cord-015021-pol2qm74	3216	30	resuscitation	resuscitation	NN
cord-015021-pol2qm74	3216	31	with	with	IN
cord-015021-pol2qm74	3216	32	two	two	CD
cord-015021-pol2qm74	3216	33	times	time	NNS
cord-015021-pol2qm74	3216	34	of	of	IN
cord-015021-pol2qm74	3216	35	SB	SB	NNP
cord-015021-pol2qm74	3216	36	volume	volume	NN
cord-015021-pol2qm74	3216	37	of	of	IN
cord-015021-pol2qm74	3216	38	Ringer	Ringer	NNP
cord-015021-pol2qm74	3216	39	's	's	POS
cord-015021-pol2qm74	3216	40	lactate	lactate	NN
cord-015021-pol2qm74	3216	41	over	over	IN
cord-015021-pol2qm74	3216	42	50	50	CD
cord-015021-pol2qm74	3216	43	rain	rain	NN
cord-015021-pol2qm74	3216	44	.	.	.
cord-015021-pol2qm74	3217	1	15	15	CD
cord-015021-pol2qm74	3217	2	animals	animal	NNS
cord-015021-pol2qm74	3217	3	received	receive	VBD
cord-015021-pol2qm74	3217	4	a	a	DT
cord-015021-pol2qm74	3217	5	bolus	bolus	NN
cord-015021-pol2qm74	3217	6	dose	dose	NN
cord-015021-pol2qm74	3217	7	(	(	-LRB-
cord-015021-pol2qm74	3217	8	20	20	CD
cord-015021-pol2qm74	3217	9	mg	mg	NNP
cord-015021-pol2qm74	3217	10	/	/	SYM
cord-015021-pol2qm74	3217	11	kg	kg	NNP
cord-015021-pol2qm74	3217	12	)	)	-RRB-
cord-015021-pol2qm74	3217	13	of	of	IN
cord-015021-pol2qm74	3217	14	TNF	TNF	NNP
cord-015021-pol2qm74	3217	15	mab	mab	NNP
cord-015021-pol2qm74	3217	16	(	(	-LRB-
cord-015021-pol2qm74	3217	17	Celltech	Celltech	NNP
cord-015021-pol2qm74	3217	18	,	,	,
cord-015021-pol2qm74	3217	19	Berkshire	Berkshire	NNP
cord-015021-pol2qm74	3217	20	,	,	,
cord-015021-pol2qm74	3217	21	UK	UK	NNP
cord-015021-pol2qm74	3217	22	)	)	-RRB-
cord-015021-pol2qm74	3217	23	at	at	IN
cord-015021-pol2qm74	3217	24	15	15	CD
cord-015021-pol2qm74	3217	25	min	min	NN
cord-015021-pol2qm74	3217	26	after	after	IN
cord-015021-pol2qm74	3217	27	resuscitation	resuscitation	NN
cord-015021-pol2qm74	3217	28	(	(	-LRB-
cord-015021-pol2qm74	3217	29	TN3	TN3	NNP
cord-015021-pol2qm74	3217	30	)	)	-RRB-
cord-015021-pol2qm74	3217	31	.	.	.
cord-015021-pol2qm74	3218	1	The	the	DT
cord-015021-pol2qm74	3218	2	control	control	NN
cord-015021-pol2qm74	3218	3	group	group	NN
cord-015021-pol2qm74	3218	4	(	(	-LRB-
cord-015021-pol2qm74	3218	5	n	n	NN
cord-015021-pol2qm74	3218	6	=	=	SYM
cord-015021-pol2qm74	3218	7	15	15	CD
cord-015021-pol2qm74	3218	8	)	)	-RRB-
cord-015021-pol2qm74	3218	9	was	be	VBD
cord-015021-pol2qm74	3218	10	treated	treat	VBN
cord-015021-pol2qm74	3218	11	similar	similar	JJ
cord-015021-pol2qm74	3218	12	to	to	IN
cord-015021-pol2qm74	3218	13	the	the	DT
cord-015021-pol2qm74	3218	14	TN3	TN3	NNP
cord-015021-pol2qm74	3218	15	group	group	NN
cord-015021-pol2qm74	3218	16	but	but	CC
cord-015021-pol2qm74	3218	17	received	receive	VBD
cord-015021-pol2qm74	3218	18	Ringer	Ringer	NNP
cord-015021-pol2qm74	3218	19	's	's	POS
cord-015021-pol2qm74	3218	20	lactate	lactate	NN
cord-015021-pol2qm74	3218	21	(	(	-LRB-
cord-015021-pol2qm74	3218	22	CON	con	NN
cord-015021-pol2qm74	3218	23	)	)	-RRB-
cord-015021-pol2qm74	3218	24	.	.	.
cord-015021-pol2qm74	3219	1	Results	result	NNS
cord-015021-pol2qm74	3219	2	:	:	:
cord-015021-pol2qm74	3220	1	At	at	IN
cord-015021-pol2qm74	3220	2	180	180	CD
cord-015021-pol2qm74	3220	3	min	min	NN
cord-015021-pol2qm74	3220	4	the	the	DT
cord-015021-pol2qm74	3220	5	prolonged	prolonged	JJ
cord-015021-pol2qm74	3220	6	HS	HS	NNP
cord-015021-pol2qm74	3220	7	resulted	result	VBD
cord-015021-pol2qm74	3220	8	in	in	IN
cord-015021-pol2qm74	3220	9	a	a	DT
cord-015021-pol2qm74	3220	10	metabolic	metabolic	JJ
cord-015021-pol2qm74	3220	11	acidosis	acidosis	NN
cord-015021-pol2qm74	3220	12	indicated	indicate	VBN
cord-015021-pol2qm74	3220	13	by	by	IN
cord-015021-pol2qm74	3220	14	a	a	DT
cord-015021-pol2qm74	3220	15	significant	significant	JJ
cord-015021-pol2qm74	3220	16	decrease	decrease	NN
cord-015021-pol2qm74	3220	17	of	of	IN
cord-015021-pol2qm74	3220	18	blood	blood	NN
cord-015021-pol2qm74	3220	19	pH	ph	NN
cord-015021-pol2qm74	3220	20	(	(	-LRB-
cord-015021-pol2qm74	3220	21	7.16	7.16	CD
cord-015021-pol2qm74	3220	22	+	+	SYM
cord-015021-pol2qm74	3220	23	0.04	0.04	CD
cord-015021-pol2qm74	3220	24	)	)	-RRB-
cord-015021-pol2qm74	3220	25	,	,	.
cord-015021-pol2qm74	3221	1	HCO3-(16.3	HCO3-(16.3	NNP
cord-015021-pol2qm74	3221	2	_	_	NN
cord-015021-pol2qm74	3221	3	_	_	NNP
cord-015021-pol2qm74	3221	4	_	_	NN
cord-015021-pol2qm74	3221	5	2.0	2.0	CD
cord-015021-pol2qm74	3221	6	mM	mm	CD
cord-015021-pol2qm74	3221	7	)	)	-RRB-
cord-015021-pol2qm74	3221	8	,	,	,
cord-015021-pol2qm74	3221	9	and	and	CC
cord-015021-pol2qm74	3221	10	base	base	NN
cord-015021-pol2qm74	3221	11	excess	excess	NN
cord-015021-pol2qm74	3221	12	(	(	-LRB-
cord-015021-pol2qm74	3221	13	-12.5	-12.5	CD
cord-015021-pol2qm74	3221	14	+	+	SYM
cord-015021-pol2qm74	3221	15	1.9	1.9	CD
cord-015021-pol2qm74	3221	16	raM	ram	NN
cord-015021-pol2qm74	3221	17	)	)	-RRB-
cord-015021-pol2qm74	3221	18	values	value	NNS
cord-015021-pol2qm74	3221	19	with	with	IN
cord-015021-pol2qm74	3221	20	pCO2	pCO2	NNP
cord-015021-pol2qm74	3221	21	(	(	-LRB-
cord-015021-pol2qm74	3221	22	47.9	47.9	CD
cord-015021-pol2qm74	3221	23	+	+	SYM
cord-015021-pol2qm74	3221	24	7.7	7.7	CD
cord-015021-pol2qm74	3221	25	mmHg	mmHg	NNPS
cord-015021-pol2qm74	3221	26	)	)	-RRB-
cord-015021-pol2qm74	3221	27	and	and	CC
cord-015021-pol2qm74	3221	28	pO2	pO2	NNP
cord-015021-pol2qm74	3221	29	(	(	-LRB-
cord-015021-pol2qm74	3221	30	136.2	136.2	CD
cord-015021-pol2qm74	3221	31	+	+	SYM
cord-015021-pol2qm74	3221	32	20.1	20.1	CD
cord-015021-pol2qm74	3221	33	mmHg	mmHg	NNS
cord-015021-pol2qm74	3221	34	)	)	-RRB-
cord-015021-pol2qm74	3221	35	in	in	IN
cord-015021-pol2qm74	3221	36	the	the	DT
cord-015021-pol2qm74	3221	37	TN3	tn3	NN
cord-015021-pol2qm74	3221	38	with	with	IN
cord-015021-pol2qm74	3221	39	no	no	DT
cord-015021-pol2qm74	3221	40	difference	difference	NN
cord-015021-pol2qm74	3221	41	to	to	IN
cord-015021-pol2qm74	3221	42	the	the	DT
cord-015021-pol2qm74	3221	43	CON	con	NN
cord-015021-pol2qm74	3221	44	group	group	NN
cord-015021-pol2qm74	3221	45	.	.	.
cord-015021-pol2qm74	3222	1	Immediately	immediately	RB
cord-015021-pol2qm74	3222	2	after	after	IN
cord-015021-pol2qm74	3222	3	resuscitation	resuscitation	NN
cord-015021-pol2qm74	3222	4	(	(	-LRB-
cord-015021-pol2qm74	3222	5	230	230	CD
cord-015021-pol2qm74	3222	6	min	min	NN
cord-015021-pol2qm74	3222	7	)	)	-RRB-
cord-015021-pol2qm74	3222	8	plasma	plasma	NN
cord-015021-pol2qm74	3222	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3222	10	levels	level	NNS
cord-015021-pol2qm74	3222	11	were	be	VBD
cord-015021-pol2qm74	3222	12	found	find	VBN
cord-015021-pol2qm74	3222	13	to	to	TO
cord-015021-pol2qm74	3222	14	be	be	VB
cord-015021-pol2qm74	3222	15	increased	increase	VBN
cord-015021-pol2qm74	3222	16	in	in	IN
cord-015021-pol2qm74	3222	17	both	both	DT
cord-015021-pol2qm74	3222	18	groups	group	NNS
cord-015021-pol2qm74	3222	19	(	(	-LRB-
cord-015021-pol2qm74	3222	20	48.8	48.8	CD
cord-015021-pol2qm74	3222	21	+	+	SYM
cord-015021-pol2qm74	3222	22	73.3	73.3	CD
cord-015021-pol2qm74	3222	23	in	in	IN
cord-015021-pol2qm74	3222	24	TN3	TN3	NNP
cord-015021-pol2qm74	3222	25	vs	vs	IN
cord-015021-pol2qm74	3222	26	30.1	30.1	CD
cord-015021-pol2qm74	3222	27	_	_	NNP
cord-015021-pol2qm74	3222	28	25.7	25.7	CD
cord-015021-pol2qm74	3222	29	pg	pg	NNP
cord-015021-pol2qm74	3222	30	/	/	SYM
cord-015021-pol2qm74	3222	31	ml	ml	NN
cord-015021-pol2qm74	3222	32	in	in	IN
cord-015021-pol2qm74	3222	33	CON	con	NN
cord-015021-pol2qm74	3222	34	group	group	NN
cord-015021-pol2qm74	3222	35	)	)	-RRB-
cord-015021-pol2qm74	3222	36	.	.	.
cord-015021-pol2qm74	3223	1	Prior	prior	RB
cord-015021-pol2qm74	3223	2	to	to	IN
cord-015021-pol2qm74	3223	3	the	the	DT
cord-015021-pol2qm74	3223	4	treatment	treatment	NN
cord-015021-pol2qm74	3223	5	with	with	IN
cord-015021-pol2qm74	3223	6	TNF	TNF	NNP
cord-015021-pol2qm74	3223	7	mab	mab	NNP
cord-015021-pol2qm74	3223	8	(	(	-LRB-
cord-015021-pol2qm74	3223	9	230	230	CD
cord-015021-pol2qm74	3223	10	min	min	NN
cord-015021-pol2qm74	3223	11	)	)	-RRB-
cord-015021-pol2qm74	3223	12	there	there	EX
cord-015021-pol2qm74	3223	13	was	be	VBD
cord-015021-pol2qm74	3223	14	also	also	RB
cord-015021-pol2qm74	3223	15	no	no	DT
cord-015021-pol2qm74	3223	16	difference	difference	NN
cord-015021-pol2qm74	3223	17	between	between	IN
cord-015021-pol2qm74	3223	18	plasma	plasma	NN
cord-015021-pol2qm74	3223	19	TNF	TNF	NNP
cord-015021-pol2qm74	3223	20	levels	level	NNS
cord-015021-pol2qm74	3223	21	of	of	IN
cord-015021-pol2qm74	3223	22	the	the	DT
cord-015021-pol2qm74	3223	23	two	two	CD
cord-015021-pol2qm74	3223	24	groups	group	NNS
cord-015021-pol2qm74	3223	25	(	(	-LRB-
cord-015021-pol2qm74	3223	26	42.1	42.1	CD
cord-015021-pol2qm74	3223	27	+	+	SYM
cord-015021-pol2qm74	3223	28	60.7	60.7	CD
cord-015021-pol2qm74	3223	29	in	in	IN
cord-015021-pol2qm74	3223	30	TN3	TN3	NNP
cord-015021-pol2qm74	3223	31	vs	vs	IN
cord-015021-pol2qm74	3223	32	60	60	CD
cord-015021-pol2qm74	3223	33	+	+	SYM
cord-015021-pol2qm74	3223	34	141.8	141.8	CD
cord-015021-pol2qm74	3223	35	pg	pg	NN
cord-015021-pol2qm74	3223	36	/	/	SYM
cord-015021-pol2qm74	3223	37	ml	ml	NN
cord-015021-pol2qm74	3223	38	in	in	IN
cord-015021-pol2qm74	3223	39	CON	con	NN
cord-015021-pol2qm74	3223	40	group	group	NN
cord-015021-pol2qm74	3223	41	)	)	-RRB-
cord-015021-pol2qm74	3223	42	.	.	.
cord-015021-pol2qm74	3224	1	Treatment	treatment	NN
cord-015021-pol2qm74	3224	2	with	with	IN
cord-015021-pol2qm74	3224	3	the	the	DT
cord-015021-pol2qm74	3224	4	TNF	TNF	NNP
cord-015021-pol2qm74	3224	5	mab	mab	NNP
cord-015021-pol2qm74	3224	6	at	at	IN
cord-015021-pol2qm74	3224	7	65	65	CD
cord-015021-pol2qm74	3224	8	rain	rain	NN
cord-015021-pol2qm74	3224	9	post	post	NN
cord-015021-pol2qm74	3224	10	-	-	NN
cord-015021-pol2qm74	3224	11	HS	HS	NNP
cord-015021-pol2qm74	3224	12	improved	improve	VBD
cord-015021-pol2qm74	3224	13	the	the	DT
cord-015021-pol2qm74	3224	14	48hour	48hour	JJ
cord-015021-pol2qm74	3224	15	survival	survival	NN
cord-015021-pol2qm74	3224	16	rate	rate	NN
cord-015021-pol2qm74	3224	17	to	to	IN
cord-015021-pol2qm74	3224	18	73.3	73.3	CD
cord-015021-pol2qm74	3224	19	%	%	NN
cord-015021-pol2qm74	3224	20	as	as	IN
cord-015021-pol2qm74	3224	21	compared	compare	VBN
cord-015021-pol2qm74	3224	22	to	to	IN
cord-015021-pol2qm74	3224	23	26.7	26.7	CD
cord-015021-pol2qm74	3224	24	%	%	NN
cord-015021-pol2qm74	3224	25	in	in	IN
cord-015021-pol2qm74	3224	26	the	the	DT
cord-015021-pol2qm74	3224	27	control	control	NN
cord-015021-pol2qm74	3224	28	group	group	NN
cord-015021-pol2qm74	3224	29	.	.	.
cord-015021-pol2qm74	3225	1	Macropathologic	Macropathologic	NNP
cord-015021-pol2qm74	3225	2	evaluations	evaluation	NNS
cord-015021-pol2qm74	3225	3	revealed	reveal	VBD
cord-015021-pol2qm74	3225	4	frequency	frequency	NN
cord-015021-pol2qm74	3225	5	of	of	IN
cord-015021-pol2qm74	3225	6	intestinal	intestinal	JJ
cord-015021-pol2qm74	3225	7	bleeding	bleeding	NN
cord-015021-pol2qm74	3225	8	in	in	IN
cord-015021-pol2qm74	3225	9	onIy	oniy	NN
cord-015021-pol2qm74	3225	10	2	2	CD
cord-015021-pol2qm74	3225	11	animals	animal	NNS
cord-015021-pol2qm74	3225	12	in	in	IN
cord-015021-pol2qm74	3225	13	the	the	DT
cord-015021-pol2qm74	3225	14	TN3	TN3	NNP
cord-015021-pol2qm74	3225	15	vs	vs	IN
cord-015021-pol2qm74	3225	16	11	11	CD
cord-015021-pol2qm74	3225	17	in	in	IN
cord-015021-pol2qm74	3225	18	the	the	DT
cord-015021-pol2qm74	3225	19	CON	con	NN
cord-015021-pol2qm74	3225	20	group	group	NN
cord-015021-pol2qm74	3225	21	.	.	.
cord-015021-pol2qm74	3226	1	No	no	DT
cord-015021-pol2qm74	3226	2	bleeding	bleed	VBG
cord-015021-pol2qm74	3226	3	in	in	IN
cord-015021-pol2qm74	3226	4	the	the	DT
cord-015021-pol2qm74	3226	5	kidneys	kidney	NNS
cord-015021-pol2qm74	3226	6	was	be	VBD
cord-015021-pol2qm74	3226	7	found	find	VBN
cord-015021-pol2qm74	3226	8	in	in	IN
cord-015021-pol2qm74	3226	9	the	the	DT
cord-015021-pol2qm74	3226	10	TN3	tn3	NN
cord-015021-pol2qm74	3226	11	but	but	CC
cord-015021-pol2qm74	3226	12	in	in	IN
cord-015021-pol2qm74	3226	13	4	4	CD
cord-015021-pol2qm74	3226	14	rats	rat	NNS
cord-015021-pol2qm74	3226	15	in	in	IN
cord-015021-pol2qm74	3226	16	the	the	DT
cord-015021-pol2qm74	3226	17	CON	con	NN
cord-015021-pol2qm74	3226	18	group	group	NN
cord-015021-pol2qm74	3226	19	.	.	.
cord-015021-pol2qm74	3227	1	The	the	DT
cord-015021-pol2qm74	3227	2	significant	significant	JJ
cord-015021-pol2qm74	3227	3	increase	increase	NN
cord-015021-pol2qm74	3227	4	in	in	IN
cord-015021-pol2qm74	3227	5	lung	lung	NN
cord-015021-pol2qm74	3227	6	wet	wet	JJ
cord-015021-pol2qm74	3227	7	weight	weight	NN
cord-015021-pol2qm74	3227	8	observed	observe	VBD
cord-015021-pol2qm74	3227	9	in	in	IN
cord-015021-pol2qm74	3227	10	non	non	NNS
cord-015021-pol2qm74	3227	11	-	-	NNS
cord-015021-pol2qm74	3227	12	survivors	survivor	NNS
cord-015021-pol2qm74	3227	13	in	in	IN
cord-015021-pol2qm74	3227	14	the	the	DT
cord-015021-pol2qm74	3227	15	CON	con	NN
cord-015021-pol2qm74	3227	16	(	(	-LRB-
cord-015021-pol2qm74	3227	17	n	n	NN
cord-015021-pol2qm74	3227	18	=	=	SYM
cord-015021-pol2qm74	3227	19	11	11	CD
cord-015021-pol2qm74	3227	20	)	)	-RRB-
cord-015021-pol2qm74	3227	21	was	be	VBD
cord-015021-pol2qm74	3227	22	prevented	prevent	VBN
cord-015021-pol2qm74	3227	23	in	in	IN
cord-015021-pol2qm74	3227	24	animals	animal	NNS
cord-015021-pol2qm74	3227	25	which	which	WDT
cord-015021-pol2qm74	3227	26	died	die	VBD
cord-015021-pol2qm74	3227	27	in	in	IN
cord-015021-pol2qm74	3227	28	the	the	DT
cord-015021-pol2qm74	3227	29	TN3	tn3	NN
cord-015021-pol2qm74	3227	30	(	(	-LRB-
cord-015021-pol2qm74	3227	31	n	n	NN
cord-015021-pol2qm74	3227	32	=	=	SYM
cord-015021-pol2qm74	3227	33	4	4	CD
cord-015021-pol2qm74	3227	34	)	)	-RRB-
cord-015021-pol2qm74	3227	35	group	group	NN
cord-015021-pol2qm74	3227	36	(	(	-LRB-
cord-015021-pol2qm74	3227	37	(	(	-LRB-
cord-015021-pol2qm74	3227	38	9.3	9.3	CD
cord-015021-pol2qm74	3227	39	+	+	CC
cord-015021-pol2qm74	3227	40	_	_	NN
cord-015021-pol2qm74	3227	41	2.4	2.4	CD
cord-015021-pol2qm74	3227	42	vs	vs	IN
cord-015021-pol2qm74	3227	43	6.3	6.3	CD
cord-015021-pol2qm74	3227	44	+	+	CC
cord-015021-pol2qm74	3227	45	_	_	NN
cord-015021-pol2qm74	3227	46	1.0	1.0	CD
cord-015021-pol2qm74	3227	47	g	g	NN
cord-015021-pol2qm74	3227	48	/	/	SYM
cord-015021-pol2qm74	3227	49	kg	kg	NNP
cord-015021-pol2qm74	3227	50	)	)	-RRB-
cord-015021-pol2qm74	3227	51	.	.	.
cord-015021-pol2qm74	3228	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	3228	2	:	:	:
cord-015021-pol2qm74	3229	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3229	2	data	datum	NNS
cord-015021-pol2qm74	3229	3	suggest	suggest	VBP
cord-015021-pol2qm74	3229	4	that	that	IN
cord-015021-pol2qm74	3229	5	TNF	TNF	NNP
cord-015021-pol2qm74	3229	6	formation	formation	NN
cord-015021-pol2qm74	3229	7	induced	induce	VBN
cord-015021-pol2qm74	3229	8	by	by	IN
cord-015021-pol2qm74	3229	9	HS	HS	NNP
cord-015021-pol2qm74	3229	10	in	in	IN
cord-015021-pol2qm74	3229	11	rats	rat	NNS
cord-015021-pol2qm74	3229	12	is	be	VBZ
cord-015021-pol2qm74	3229	13	an	an	DT
cord-015021-pol2qm74	3229	14	important	important	JJ
cord-015021-pol2qm74	3229	15	mediator	mediator	NN
cord-015021-pol2qm74	3229	16	for	for	IN
cord-015021-pol2qm74	3229	17	pathophysiologic	pathophysiologic	JJ
cord-015021-pol2qm74	3229	18	alterations	alteration	NNS
cord-015021-pol2qm74	3229	19	leading	lead	VBG
cord-015021-pol2qm74	3229	20	to	to	IN
cord-015021-pol2qm74	3229	21	multi	multi	JJ
cord-015021-pol2qm74	3229	22	organ	organ	NN
cord-015021-pol2qm74	3229	23	failure	failure	NN
cord-015021-pol2qm74	3229	24	and	and	CC
cord-015021-pol2qm74	3229	25	lethality	lethality	NN
cord-015021-pol2qm74	3229	26	.	.	.
cord-015021-pol2qm74	3230	1	Antibodies	antibody	NNS
cord-015021-pol2qm74	3230	2	to	to	IN
cord-015021-pol2qm74	3230	3	TNF	TNF	NNP
cord-015021-pol2qm74	3230	4	might	may	MD
cord-015021-pol2qm74	3230	5	be	be	VB
cord-015021-pol2qm74	3230	6	a	a	DT
cord-015021-pol2qm74	3230	7	useful	useful	JJ
cord-015021-pol2qm74	3230	8	agent	agent	NN
cord-015021-pol2qm74	3230	9	in	in	IN
cord-015021-pol2qm74	3230	10	the	the	DT
cord-015021-pol2qm74	3230	11	treatment	treatment	NN
cord-015021-pol2qm74	3230	12	of	of	IN
cord-015021-pol2qm74	3230	13	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	3230	14	shock	shock	NN
cord-015021-pol2qm74	3230	15	related	relate	VBN
cord-015021-pol2qm74	3230	16	disorders	disorder	NNS
cord-015021-pol2qm74	3230	17	.	.	.
cord-015021-pol2qm74	3231	1	55-+8	55-+8	CD
cord-015021-pol2qm74	3231	2	n	n	NN
cord-015021-pol2qm74	3231	3	=	=	SYM
cord-015021-pol2qm74	3231	4	ll*$	ll*$	NNP
cord-015021-pol2qm74	3232	1	15-+5	15-+5	CD
cord-015021-pol2qm74	3232	2	n=7	n=7	JJ
cord-015021-pol2qm74	3232	3	78_+22	78_+22	CD
cord-015021-pol2qm74	3233	1	n=5	n=5	JJ
cord-015021-pol2qm74	3234	1	*	*	NFP
cord-015021-pol2qm74	3234	2	*	*	NFP
cord-015021-pol2qm74	3234	3	p<0.05	p<0.05	NN
cord-015021-pol2qm74	3234	4	vs	vs	IN
cord-015021-pol2qm74	3234	5	BASELINE	BASELINE	NNP
cord-015021-pol2qm74	3234	6	:	:	:
cord-015021-pol2qm74	3235	1	~p<0.05	~p<0.05	NFP
cord-015021-pol2qm74	3236	1	no	no	DT
cord-015021-pol2qm74	3236	2	anesthesia	anesthesia	NN
cord-015021-pol2qm74	3236	3	vs	vs	IN
cord-015021-pol2qm74	3236	4	anesthesia	anesthesia	NN
cord-015021-pol2qm74	3237	1	Thus	thus	RB
cord-015021-pol2qm74	3237	2	1	1	CD
cord-015021-pol2qm74	3237	3	)	)	-RRB-
cord-015021-pol2qm74	3237	4	TNF	tnf	NN
cord-015021-pol2qm74	3237	5	production	production	NN
cord-015021-pol2qm74	3237	6	increased	increase	VBD
cord-015021-pol2qm74	3237	7	2	2	CD
cord-015021-pol2qm74	3237	8	-	-	SYM
cord-015021-pol2qm74	3237	9	3	3	CD
cord-015021-pol2qm74	3237	10	fold	fold	VB
cord-015021-pol2qm74	3237	11	by	by	IN
cord-015021-pol2qm74	3237	12	48	48	CD
cord-015021-pol2qm74	3237	13	-	-	SYM
cord-015021-pol2qm74	3237	14	72	72	CD
cord-015021-pol2qm74	3237	15	hrs	hrs	NN
cord-015021-pol2qm74	3237	16	following	follow	VBG
cord-015021-pol2qm74	3237	17	trauma	trauma	NN
cord-015021-pol2qm74	3237	18	in	in	IN
cord-015021-pol2qm74	3237	19	unstimulated	unstimulated	JJ
cord-015021-pol2qm74	3237	20	blood	blood	NN
cord-015021-pol2qm74	3237	21	,	,	,
cord-015021-pol2qm74	3237	22	but	but	CC
cord-015021-pol2qm74	3237	23	was	be	VBD
cord-015021-pol2qm74	3237	24	reduced	reduce	VBN
cord-015021-pol2qm74	3237	25	or	or	CC
cord-015021-pol2qm74	3237	26	not	not	RB
cord-015021-pol2qm74	3237	27	changed	change	VBN
cord-015021-pol2qm74	3237	28	after	after	IN
cord-015021-pol2qm74	3237	29	LPS	LPS	NNP
cord-015021-pol2qm74	3237	30	stimulation	stimulation	NN
cord-015021-pol2qm74	3237	31	,	,	,
cord-015021-pol2qm74	3237	32	so	so	IN
cord-015021-pol2qm74	3237	33	circulating	circulate	VBG
cord-015021-pol2qm74	3237	34	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	3237	35	are	be	VBP
cord-015021-pol2qm74	3237	36	probably	probably	RB
cord-015021-pol2qm74	3237	37	not	not	RB
cord-015021-pol2qm74	3237	38	an	an	DT
cord-015021-pol2qm74	3237	39	important	important	JJ
cord-015021-pol2qm74	3237	40	source	source	NN
cord-015021-pol2qm74	3237	41	of	of	IN
cord-015021-pol2qm74	3237	42	TNF	TNF	NNP
cord-015021-pol2qm74	3237	43	post	post	NN
cord-015021-pol2qm74	3237	44	trauma	trauma	NN
cord-015021-pol2qm74	3237	45	;	;	:
cord-015021-pol2qm74	3238	1	2	2	LS
cord-015021-pol2qm74	3238	2	)	)	-RRB-
cord-015021-pol2qm74	3238	3	antiCD18	antiCD18	NFP
cord-015021-pol2qm74	3238	4	had	have	VBD
cord-015021-pol2qm74	3238	5	no	no	DT
cord-015021-pol2qm74	3238	6	obvious	obvious	JJ
cord-015021-pol2qm74	3238	7	effect	effect	NN
cord-015021-pol2qm74	3238	8	on	on	IN
cord-015021-pol2qm74	3238	9	TNF	TNF	NNP
cord-015021-pol2qm74	3238	10	production	production	NN
cord-015021-pol2qm74	3238	11	in	in	IN
cord-015021-pol2qm74	3238	12	unstimulated	unstimulated	JJ
cord-015021-pol2qm74	3238	13	or	or	CC
cord-015021-pol2qm74	3238	14	LPS	lp	NNS
cord-015021-pol2qm74	3238	15	stimulated	stimulate	VBD
cord-015021-pol2qm74	3238	16	blood	blood	NN
cord-015021-pol2qm74	3238	17	,	,	,
cord-015021-pol2qm74	3238	18	relative	relative	JJ
cord-015021-pol2qm74	3238	19	to	to	IN
cord-015021-pol2qm74	3238	20	vehicle	vehicle	NN
cord-015021-pol2qm74	3238	21	,	,	,
cord-015021-pol2qm74	3238	22	which	which	WDT
cord-015021-pol2qm74	3238	23	suggests	suggest	VBZ
cord-015021-pol2qm74	3238	24	that	that	IN
cord-015021-pol2qm74	3238	25	the	the	DT
cord-015021-pol2qm74	3238	26	protective	protective	JJ
cord-015021-pol2qm74	3238	27	mechanism	mechanism	NN
cord-015021-pol2qm74	3238	28	of	of	IN
cord-015021-pol2qm74	3238	29	antiCD18	antiCD18	:
cord-015021-pol2qm74	3238	30	does	do	VBZ
cord-015021-pol2qm74	3238	31	not	not	RB
cord-015021-pol2qm74	3238	32	involve	involve	VB
cord-015021-pol2qm74	3238	33	TNF	TNF	NNP
cord-015021-pol2qm74	3238	34	suppression	suppression	NN
cord-015021-pol2qm74	3238	35	;	;	:
cord-015021-pol2qm74	3238	36	3	3	LS
cord-015021-pol2qm74	3238	37	)	)	-RRB-
cord-015021-pol2qm74	3238	38	fentanyl	fentanyl	NN
cord-015021-pol2qm74	3238	39	anesthesia	anesthesia	NN
cord-015021-pol2qm74	3238	40	at	at	IN
cord-015021-pol2qm74	3238	41	72	72	CD
cord-015021-pol2qm74	3238	42	hrs	hrs	NN
cord-015021-pol2qm74	3238	43	following	follow	VBG
cord-015021-pol2qm74	3238	44	trauma	trauma	NN
cord-015021-pol2qm74	3238	45	unexpectedly	unexpectedly	RB
cord-015021-pol2qm74	3238	46	decreased	decrease	VBD
cord-015021-pol2qm74	3238	47	LPS	LPS	NNP
cord-015021-pol2qm74	3238	48	-	-	HYPH
cord-015021-pol2qm74	3238	49	evoked	evoke	VBN
cord-015021-pol2qm74	3238	50	TNF	tnf	NN
cord-015021-pol2qm74	3238	51	production	production	NN
cord-015021-pol2qm74	3238	52	,	,	,
cord-015021-pol2qm74	3238	53	which	which	WDT
cord-015021-pol2qm74	3238	54	suggests	suggest	VBZ
cord-015021-pol2qm74	3238	55	that	that	IN
cord-015021-pol2qm74	3238	56	anesthesia	anesthesia	NN
cord-015021-pol2qm74	3238	57	alone	alone	RB
cord-015021-pol2qm74	3238	58	can	can	MD
cord-015021-pol2qm74	3238	59	influence	influence	VB
cord-015021-pol2qm74	3238	60	an	an	DT
cord-015021-pol2qm74	3238	61	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3238	62	response	response	NN
cord-015021-pol2qm74	3238	63	.	.	.
cord-015021-pol2qm74	3239	1	Proinflamrnato~	Proinflamrnato~	NNP
cord-015021-pol2qm74	3239	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	3239	3	have	have	VBP
cord-015021-pol2qm74	3239	4	been	be	VBN
cord-015021-pol2qm74	3239	5	shown	show	VBN
cord-015021-pol2qm74	3239	6	to	to	TO
cord-015021-pol2qm74	3239	7	play	play	VB
cord-015021-pol2qm74	3239	8	a	a	DT
cord-015021-pol2qm74	3239	9	signific	signific	NN
cord-015021-pol2qm74	3239	10	~	~	NFP
cord-015021-pol2qm74	3239	11	t	t	XX
cord-015021-pol2qm74	3239	12	role	role	NN
cord-015021-pol2qm74	3239	13	in	in	IN
cord-015021-pol2qm74	3239	14	the	the	DT
cord-015021-pol2qm74	3239	15	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	3239	16	of	of	IN
cord-015021-pol2qm74	3239	17	sepsis	sepsis	NN
cord-015021-pol2qm74	3239	18	,	,	,
cord-015021-pol2qm74	3239	19	which	which	WDT
cord-015021-pol2qm74	3239	20	is	be	VBZ
cord-015021-pol2qm74	3239	21	a	a	DT
cord-015021-pol2qm74	3239	22	very	very	RB
cord-015021-pol2qm74	3239	23	common	common	JJ
cord-015021-pol2qm74	3239	24	occurrence	occurrence	NN
cord-015021-pol2qm74	3239	25	in	in	IN
cord-015021-pol2qm74	3239	26	born	bear	VBN
cord-015021-pol2qm74	3239	27	injury	injury	NN
cord-015021-pol2qm74	3239	28	.	.	.
cord-015021-pol2qm74	3240	1	TNFa	TNFa	NNP
cord-015021-pol2qm74	3240	2	is	be	VBZ
cord-015021-pol2qm74	3240	3	infrequently	infrequently	RB
cord-015021-pol2qm74	3240	4	detected	detect	VBN
cord-015021-pol2qm74	3240	5	in	in	IN
cord-015021-pol2qm74	3240	6	the	the	DT
cord-015021-pol2qm74	3240	7	blood	blood	NN
cord-015021-pol2qm74	3240	8	of	of	IN
cord-015021-pol2qm74	3240	9	burned	burn	VBN
cord-015021-pol2qm74	3240	10	patients	patient	NNS
cord-015021-pol2qm74	3240	11	,	,	,
cord-015021-pol2qm74	3240	12	the	the	DT
cord-015021-pol2qm74	3240	13	ability	ability	NN
cord-015021-pol2qm74	3240	14	to	to	TO
cord-015021-pol2qm74	3240	15	detect	detect	VB
cord-015021-pol2qm74	3240	16	the	the	DT
cord-015021-pol2qm74	3240	17	shed	shed	JJ
cord-015021-pol2qm74	3240	18	receptors	receptor	NNS
cord-015021-pol2qm74	3240	19	of	of	IN
cord-015021-pol2qm74	3240	20	sTNFg	sTNFg	NNP
cord-015021-pol2qm74	3240	21	has	have	VBZ
cord-015021-pol2qm74	3240	22	not	not	RB
cord-015021-pol2qm74	3240	23	been	be	VBN
cord-015021-pol2qm74	3240	24	determined	determine	VBN
cord-015021-pol2qm74	3240	25	.	.	.
cord-015021-pol2qm74	3241	1	Serial	serial	JJ
cord-015021-pol2qm74	3241	2	serum	serum	NN
cord-015021-pol2qm74	3241	3	Mmples	Mmples	NNPS
cord-015021-pol2qm74	3241	4	from	from	IN
cord-015021-pol2qm74	3241	5	burn	burn	NN
cord-015021-pol2qm74	3241	6	patients	patient	NNS
cord-015021-pol2qm74	3241	7	were	be	VBD
cord-015021-pol2qm74	3241	8	collected	collect	VBN
cord-015021-pol2qm74	3241	9	from	from	IN
cord-015021-pol2qm74	3241	10	the	the	DT
cord-015021-pol2qm74	3241	11	time	time	NN
cord-015021-pol2qm74	3241	12	of	of	IN
cord-015021-pol2qm74	3241	13	admission	admission	NN
cord-015021-pol2qm74	3241	14	until	until	IN
cord-015021-pol2qm74	3241	15	death	death	NN
cord-015021-pol2qm74	3241	16	from	from	IN
cord-015021-pol2qm74	3241	17	septic	septic	JJ
cord-015021-pol2qm74	3241	18	shock	shock	NN
cord-015021-pol2qm74	3241	19	.	.	.
cord-015021-pol2qm74	3242	1	These	these	DT
cord-015021-pol2qm74	3242	2	samples	sample	NNS
cord-015021-pol2qm74	3242	3	were	be	VBD
cord-015021-pol2qm74	3242	4	analyzed	analyze	VBN
cord-015021-pol2qm74	3242	5	using	use	VBG
cord-015021-pol2qm74	3242	6	an	an	DT
cord-015021-pol2qm74	3242	7	enzyme	enzyme	NN
cord-015021-pol2qm74	3242	8	-	-	HYPH
cord-015021-pol2qm74	3242	9	linked	link	VBN
cord-015021-pol2qm74	3242	10	immunosorbent	immunosorbent	JJ
cord-015021-pol2qm74	3242	11	assay	assay	NN
cord-015021-pol2qm74	3242	12	(	(	-LRB-
cord-015021-pol2qm74	3242	13	ELISA	ELISA	NNP
cord-015021-pol2qm74	3242	14	)	)	-RRB-
cord-015021-pol2qm74	3242	15	for	for	IN
cord-015021-pol2qm74	3242	16	sTNFr	sTNFr	NNP
cord-015021-pol2qm74	3242	17	,	,	,
cord-015021-pol2qm74	3242	18	L	L	NNP
cord-015021-pol2qm74	3242	19	-	-	HYPH
cord-015021-pol2qm74	3242	20	Ira	Ira	NNP
cord-015021-pol2qm74	3242	21	,	,	,
cord-015021-pol2qm74	3242	22	TNF	TNF	NNP
cord-015021-pol2qm74	3242	23	-	-	HYPH
cord-015021-pol2qm74	3242	24	a	a	NNP
cord-015021-pol2qm74	3242	25	,	,	,
cord-015021-pol2qm74	3242	26	and	and	CC
cord-015021-pol2qm74	3242	27	IL	IL	NNP
cord-015021-pol2qm74	3242	28	-	-	HYPH
cord-015021-pol2qm74	3242	29	Ib	Ib	NNP
cord-015021-pol2qm74	3242	30	.	.	.
cord-015021-pol2qm74	3243	1	The	the	DT
cord-015021-pol2qm74	3243	2	patients	patient	NNS
cord-015021-pol2qm74	3243	3	ranged	range	VBD
cord-015021-pol2qm74	3243	4	in	in	IN
cord-015021-pol2qm74	3243	5	age	age	NN
cord-015021-pol2qm74	3243	6	from	from	IN
cord-015021-pol2qm74	3243	7	26	26	CD
cord-015021-pol2qm74	3243	8	to	to	TO
cord-015021-pol2qm74	3243	9	72	72	CD
cord-015021-pol2qm74	3243	10	yeas	yea	NNS
cord-015021-pol2qm74	3243	11	of	of	IN
cord-015021-pol2qm74	3243	12	age	age	NN
cord-015021-pol2qm74	3243	13	.	.	.
cord-015021-pol2qm74	3244	1	The	the	DT
cord-015021-pol2qm74	3244	2	percentages	percentage	NNS
cord-015021-pol2qm74	3244	3	of	of	IN
cord-015021-pol2qm74	3244	4	bum	bum	NN
cord-015021-pol2qm74	3244	5	ranged	range	VBD
cord-015021-pol2qm74	3244	6	from	from	IN
cord-015021-pol2qm74	3244	7	40	40	CD
cord-015021-pol2qm74	3244	8	%	%	NN
cord-015021-pol2qm74	3244	9	-90	-90	NN
cord-015021-pol2qm74	3244	10	%	%	NN
cord-015021-pol2qm74	3244	11	.	.	.
cord-015021-pol2qm74	3245	1	Cytokine	cytokine	NN
cord-015021-pol2qm74	3245	2	concenlrntions	concenlrntion	NNS
cord-015021-pol2qm74	3245	3	vmled	vmle	VBD
cord-015021-pol2qm74	3245	4	from	from	IN
cord-015021-pol2qm74	3245	5	patient	patient	NN
cord-015021-pol2qm74	3245	6	to	to	IN
cord-015021-pol2qm74	3245	7	padent	padent	NN
cord-015021-pol2qm74	3245	8	irrespective	irrespective	RB
cord-015021-pol2qm74	3245	9	of	of	IN
cord-015021-pol2qm74	3245	10	bum	bum	JJ
cord-015021-pol2qm74	3245	11	size	size	NN
cord-015021-pol2qm74	3245	12	.	.	.
cord-015021-pol2qm74	3246	1	TNFa	TNFa	NNP
cord-015021-pol2qm74	3246	2	levels	level	NNS
cord-015021-pol2qm74	3246	3	were	be	VBD
cord-015021-pol2qm74	3246	4	consistentiy	consistentiy	NNS
cord-015021-pol2qm74	3246	5	in	in	IN
cord-015021-pol2qm74	3246	6	the	the	DT
cord-015021-pol2qm74	3246	7	range	range	NN
cord-015021-pol2qm74	3246	8	of30pgJml	of30pgJml	NNP
cord-015021-pol2qm74	3246	9	-150pg	-150pg	NNP
cord-015021-pol2qm74	3246	10	/	/	SYM
cord-015021-pol2qm74	3246	11	ml	ml	NN
cord-015021-pol2qm74	3246	12	.	.	.
cord-015021-pol2qm74	3247	1	Peaks	peak	NNS
cord-015021-pol2qm74	3247	2	in	in	IN
cord-015021-pol2qm74	3247	3	the	the	DT
cord-015021-pol2qm74	3247	4	TNFa	TNFa	NNS
cord-015021-pol2qm74	3247	5	values	value	NNS
cord-015021-pol2qm74	3247	6	were	be	VBD
cord-015021-pol2qm74	3247	7	above	above	IN
cord-015021-pol2qm74	3247	8	90pg	90pg	NN
cord-015021-pol2qm74	3247	9	/	/	SYM
cord-015021-pol2qm74	3247	10	ml	ml	NN
cord-015021-pol2qm74	3247	11	and	and	CC
cord-015021-pol2qm74	3247	12	were	be	VBD
cord-015021-pol2qm74	3247	13	also	also	RB
cord-015021-pol2qm74	3247	14	associated	associate	VBN
cord-015021-pol2qm74	3247	15	with	with	IN
cord-015021-pol2qm74	3247	16	a	a	DT
cord-015021-pol2qm74	3247	17	peak	peak	NN
cord-015021-pol2qm74	3247	18	in	in	IN
cord-015021-pol2qm74	3247	19	the	the	DT
cord-015021-pol2qm74	3247	20	sTNFr	stnfr	CD
cord-015021-pol2qm74	3247	21	levels	level	NNS
cord-015021-pol2qm74	3247	22	.	.	.
cord-015021-pol2qm74	3248	1	These	these	DT
cord-015021-pol2qm74	3248	2	levels	level	NNS
cord-015021-pol2qm74	3248	3	began	begin	VBD
cord-015021-pol2qm74	3248	4	at	at	IN
cord-015021-pol2qm74	3248	5	<	<	XX
cord-015021-pol2qm74	3248	6	10,000pghnl	10,000pghnl	CD
cord-015021-pol2qm74	3248	7	within	within	IN
cord-015021-pol2qm74	3248	8	the	the	DT
cord-015021-pol2qm74	3248	9	In	In	NNP
cord-015021-pol2qm74	3248	10	,	,	,
cord-015021-pol2qm74	3248	11	st	st	NNP
cord-015021-pol2qm74	3248	12	6	6	CD
cord-015021-pol2qm74	3248	13	Ins	Ins	NNPS
cord-015021-pol2qm74	3248	14	of	of	IN
cord-015021-pol2qm74	3248	15	injury	injury	NN
cord-015021-pol2qm74	3248	16	and	and	CC
cord-015021-pol2qm74	3248	17	gradually	gradually	RB
cord-015021-pol2qm74	3248	18	increased	increase	VBD
cord-015021-pol2qm74	3248	19	with	with	IN
cord-015021-pol2qm74	3248	20	time	time	NN
cord-015021-pol2qm74	3248	21	.	.	.
cord-015021-pol2qm74	3249	1	Clinically	clinically	RB
cord-015021-pol2qm74	3249	2	.	.	.
cord-015021-pol2qm74	3250	1	ti~	ti~	NNP
cord-015021-pol2qm74	3250	2	appearance	appearance	NN
cord-015021-pol2qm74	3250	3	of	of	IN
cord-015021-pol2qm74	3250	4	eytoklnes	eytoklne	NNS
cord-015021-pol2qm74	3250	5	was	be	VBD
cord-015021-pol2qm74	3250	6	independent	independent	JJ
cord-015021-pol2qm74	3250	7	of	of	IN
cord-015021-pol2qm74	3250	8	positive	positive	JJ
cord-015021-pol2qm74	3250	9	wound	wound	NN
cord-015021-pol2qm74	3250	10	,	,	,
cord-015021-pol2qm74	3250	11	blood	blood	NN
cord-015021-pol2qm74	3250	12	,	,	,
cord-015021-pol2qm74	3250	13	or	or	CC
cord-015021-pol2qm74	3250	14	respiratory	respiratory	JJ
cord-015021-pol2qm74	3250	15	cultures	culture	NNS
cord-015021-pol2qm74	3250	16	however	however	RB
cord-015021-pol2qm74	3250	17	peak	peak	VBP
cord-015021-pol2qm74	3250	18	values	value	NNS
cord-015021-pol2qm74	3250	19	in	in	IN
cord-015021-pol2qm74	3250	20	TNFa	TNFa	NNS
cord-015021-pol2qm74	3250	21	and	and	CC
cord-015021-pol2qm74	3251	1	sTNFr	sTNFr	VBN
cord-015021-pol2qm74	3251	2	were	be	VBD
cord-015021-pol2qm74	3251	3	~ialed	~iale	VBN
cord-015021-pol2qm74	3251	4	with	with	IN
cord-015021-pol2qm74	3251	5	a	a	DT
cord-015021-pol2qm74	3251	6	fluid	fluid	JJ
cord-015021-pol2qm74	3251	7	requirnmenL	requirnmenL	NNP
cord-015021-pol2qm74	3251	8	Levels	level	NNS
cord-015021-pol2qm74	3251	9	of	of	IN
cord-015021-pol2qm74	3251	10	IL	IL	NNP
cord-015021-pol2qm74	3251	11	-	-	:
cord-015021-pol2qm74	3251	12	I	I	NNP
cord-015021-pol2qm74	3251	13	ra	ra	NNP
cord-015021-pol2qm74	3251	14	were	be	VBD
cord-015021-pol2qm74	3251	15	also	also	RB
cord-015021-pol2qm74	3251	16	elevated	elevate	VBN
cord-015021-pol2qm74	3251	17	independent	independent	JJ
cord-015021-pol2qm74	3251	18	of	of	IN
cord-015021-pol2qm74	3251	19	clinical	clinical	JJ
cord-015021-pol2qm74	3251	20	findings	finding	NNS
cord-015021-pol2qm74	3251	21	as	as	RB
cord-015021-pol2qm74	3251	22	well	well	RB
cord-015021-pol2qm74	3251	23	as	as	IN
cord-015021-pol2qm74	3251	24	extent	extent	NN
cord-015021-pol2qm74	3251	25	of	of	IN
cord-015021-pol2qm74	3251	26	injury	injury	NN
cord-015021-pol2qm74	3251	27	.	.	.
cord-015021-pol2qm74	3252	1	In	in	IN
cord-015021-pol2qm74	3252	2	PL5	PL5	NNP
cord-015021-pol2qm74	3252	3	there	there	EX
cord-015021-pol2qm74	3252	4	is	be	VBZ
cord-015021-pol2qm74	3252	5	a	a	DT
cord-015021-pol2qm74	3252	6	significant	significant	JJ
cord-015021-pol2qm74	3252	7	corresponding	corresponding	JJ
cord-015021-pol2qm74	3252	8	peak	peak	NN
cord-015021-pol2qm74	3252	9	in	in	IN
cord-015021-pol2qm74	3252	10	IL	IL	NNP
cord-015021-pol2qm74	3252	11	-	-	HYPH
cord-015021-pol2qm74	3252	12	trn	trn	NNP
cord-015021-pol2qm74	3252	13	(	(	-LRB-
cord-015021-pol2qm74	3252	14	>	>	NFP
cord-015021-pol2qm74	3252	15	40~8	40~8	CD
cord-015021-pol2qm74	3252	16	/	/	SYM
cord-015021-pol2qm74	3252	17	ml	ml	NN
cord-015021-pol2qm74	3252	18	)	)	-RRB-
cord-015021-pol2qm74	3252	19	at	at	IN
cord-015021-pol2qm74	3252	20	the	the	DT
cord-015021-pol2qm74	3252	21	same	same	JJ
cord-015021-pol2qm74	3252	22	time	time	NN
cord-015021-pol2qm74	3252	23	as	as	IN
cord-015021-pol2qm74	3252	24	T/~:a	T/~:a	NNP
cord-015021-pol2qm74	3252	25	and	and	CC
cord-015021-pol2qm74	3252	26	sTNFr	stnfr	CD
cord-015021-pol2qm74	3252	27	levels	level	NNS
cord-015021-pol2qm74	3252	28	.	.	.
cord-015021-pol2qm74	3253	1	We	-PRON-	PRP
cord-015021-pol2qm74	3253	2	aimed	aim	VBD
cord-015021-pol2qm74	3253	3	to	to	TO
cord-015021-pol2qm74	3253	4	characterise	characterise	VB
cord-015021-pol2qm74	3253	5	the	the	DT
cord-015021-pol2qm74	3253	6	pattern	pattern	NN
cord-015021-pol2qm74	3253	7	of	of	IN
cord-015021-pol2qm74	3253	8	secretion	secretion	NN
cord-015021-pol2qm74	3253	9	of	of	IN
cord-015021-pol2qm74	3253	10	interleukin-1	interleukin-1	NN
cord-015021-pol2qm74	3253	11	beta	beta	NN
cord-015021-pol2qm74	3253	12	0L	0l	NN
cord-015021-pol2qm74	3253	13	-	-	HYPH
cord-015021-pol2qm74	3253	14	II3	ii3	JJ
cord-015021-pol2qm74	3253	15	)	)	-RRB-
cord-015021-pol2qm74	3253	16	,	,	,
cord-015021-pol2qm74	3253	17	intefleukin-6	intefleukin-6	NNP
cord-015021-pol2qm74	3253	18	(	(	-LRB-
cord-015021-pol2qm74	3253	19	IL-6	IL-6	NNP
cord-015021-pol2qm74	3253	20	)	)	-RRB-
cord-015021-pol2qm74	3253	21	and	and	CC
cord-015021-pol2qm74	3253	22	tumour	tumour	NN
cord-015021-pol2qm74	3253	23	necrosis	necrosis	NN
cord-015021-pol2qm74	3253	24	factor	factor	NN
cord-015021-pol2qm74	3253	25	alpha	alpha	NN
cord-015021-pol2qm74	3253	26	(	(	-LRB-
cord-015021-pol2qm74	3253	27	TNFa	TNFa	NNP
cord-015021-pol2qm74	3253	28	)	)	-RRB-
cord-015021-pol2qm74	3253	29	in	in	IN
cord-015021-pol2qm74	3253	30	multiply	multiply	NN
cord-015021-pol2qm74	3253	31	injured	injure	VBN
cord-015021-pol2qm74	3253	32	patients	patient	NNS
cord-015021-pol2qm74	3253	33	and	and	CC
cord-015021-pol2qm74	3253	34	to	to	TO
cord-015021-pol2qm74	3253	35	relate	relate	VB
cord-015021-pol2qm74	3253	36	these	these	DT
cord-015021-pol2qm74	3253	37	results	result	NNS
cord-015021-pol2qm74	3253	38	to	to	IN
cord-015021-pol2qm74	3253	39	their	-PRON-	PRP$
cord-015021-pol2qm74	3253	40	clinical	clinical	JJ
cord-015021-pol2qm74	3253	41	condition	condition	NN
cord-015021-pol2qm74	3253	42	and	and	CC
cord-015021-pol2qm74	3253	43	outcome	outcome	NN
cord-015021-pol2qm74	3253	44	.	.	.
cord-015021-pol2qm74	3254	1	Two	two	CD
cord-015021-pol2qm74	3254	2	hourly	hourly	JJ
cord-015021-pol2qm74	3254	3	blood	blood	NN
cord-015021-pol2qm74	3254	4	samples	sample	NNS
cord-015021-pol2qm74	3254	5	were	be	VBD
cord-015021-pol2qm74	3254	6	taken	take	VBN
cord-015021-pol2qm74	3254	7	from	from	IN
cord-015021-pol2qm74	3254	8	ten	ten	CD
cord-015021-pol2qm74	3254	9	patients	patient	NNS
cord-015021-pol2qm74	3254	10	from	from	IN
cord-015021-pol2qm74	3254	11	the	the	DT
cord-015021-pol2qm74	3254	12	time	time	NN
cord-015021-pol2qm74	3254	13	of	of	IN
cord-015021-pol2qm74	3254	14	injury	injury	NN
cord-015021-pol2qm74	3254	15	until	until	IN
cord-015021-pol2qm74	3254	16	48	48	CD
cord-015021-pol2qm74	3254	17	hours	hour	NNS
cord-015021-pol2qm74	3254	18	.	.	.
cord-015021-pol2qm74	3255	1	Cytokine	cytokine	NN
cord-015021-pol2qm74	3255	2	levels	level	NNS
cord-015021-pol2qm74	3255	3	were	be	VBD
cord-015021-pol2qm74	3255	4	measured	measure	VBN
cord-015021-pol2qm74	3255	5	using	use	VBG
cord-015021-pol2qm74	3255	6	sandwich	sandwich	NN
cord-015021-pol2qm74	3255	7	enzyme	enzyme	NN
cord-015021-pol2qm74	3255	8	-	-	HYPH
cord-015021-pol2qm74	3255	9	linked	link	VBN
cord-015021-pol2qm74	3255	10	immunosorbent	immunosorbent	JJ
cord-015021-pol2qm74	3255	11	assays	assay	NNS
cord-015021-pol2qm74	3255	12	(	(	-LRB-
cord-015021-pol2qm74	3255	13	ELISAs	elisa	NNS
cord-015021-pol2qm74	3255	14	)	)	-RRB-
cord-015021-pol2qm74	3255	15	.	.	.
cord-015021-pol2qm74	3256	1	Injury	injury	NN
cord-015021-pol2qm74	3256	2	Severity	severity	NN
cord-015021-pol2qm74	3256	3	Scores	score	NNS
cord-015021-pol2qm74	3256	4	(	(	-LRB-
cord-015021-pol2qm74	3256	5	ISS	ISS	NNP
cord-015021-pol2qm74	3256	6	)	)	-RRB-
cord-015021-pol2qm74	3256	7	were	be	VBD
cord-015021-pol2qm74	3256	8	calculated	calculate	VBN
cord-015021-pol2qm74	3256	9	and	and	CC
cord-015021-pol2qm74	3256	10	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	3256	11	was	be	VBD
cord-015021-pol2qm74	3256	12	assessed	assess	VBN
cord-015021-pol2qm74	3256	13	from	from	IN
cord-015021-pol2qm74	3256	14	the	the	DT
cord-015021-pol2qm74	3256	15	blood	blood	NN
cord-015021-pol2qm74	3256	16	transfusion	transfusion	NN
cord-015021-pol2qm74	3256	17	requirement	requirement	NN
cord-015021-pol2qm74	3256	18	over	over	IN
cord-015021-pol2qm74	3256	19	the	the	DT
cord-015021-pol2qm74	3256	20	48	48	CD
cord-015021-pol2qm74	3256	21	hours	hour	NNS
cord-015021-pol2qm74	3256	22	.	.	.
cord-015021-pol2qm74	3257	1	Patients	patient	NNS
cord-015021-pol2qm74	3257	2	'	'	POS
cord-015021-pol2qm74	3257	3	ages	age	NNS
cord-015021-pol2qm74	3257	4	ranged	range	VBD
cord-015021-pol2qm74	3257	5	from	from	IN
cord-015021-pol2qm74	3257	6	17	17	CD
cord-015021-pol2qm74	3257	7	to	to	TO
cord-015021-pol2qm74	3257	8	86	86	CD
cord-015021-pol2qm74	3257	9	years	year	NNS
cord-015021-pol2qm74	3257	10	.	.	.
cord-015021-pol2qm74	3258	1	ISS	ISS	NNP
cord-015021-pol2qm74	3258	2	varied	vary	VBD
cord-015021-pol2qm74	3258	3	from	from	IN
cord-015021-pol2qm74	3258	4	9	9	CD
cord-015021-pol2qm74	3258	5	to	to	IN
cord-015021-pol2qm74	3258	6	50	50	CD
cord-015021-pol2qm74	3258	7	and	and	CC
cord-015021-pol2qm74	3258	8	transfusion	transfusion	NN
cord-015021-pol2qm74	3258	9	requirement	requirement	NN
cord-015021-pol2qm74	3258	10	from	from	IN
cord-015021-pol2qm74	3258	11	0	0	CD
cord-015021-pol2qm74	3258	12	to	to	IN
cord-015021-pol2qm74	3258	13	14	14	CD
cord-015021-pol2qm74	3258	14	units	unit	NNS
cord-015021-pol2qm74	3258	15	.	.	.
cord-015021-pol2qm74	3259	1	Five	five	CD
cord-015021-pol2qm74	3259	2	patients	patient	NNS
cord-015021-pol2qm74	3259	3	died	die	VBD
cord-015021-pol2qm74	3259	4	after	after	IN
cord-015021-pol2qm74	3259	5	the	the	DT
cord-015021-pol2qm74	3259	6	study	study	NN
cord-015021-pol2qm74	3259	7	period	period	NN
cord-015021-pol2qm74	3259	8	.	.	.
cord-015021-pol2qm74	3259	9	]	]	-RRB-
cord-015021-pol2qm74	3260	1	1,-6	1,-6	CD
cord-015021-pol2qm74	3260	2	was	be	VBD
cord-015021-pol2qm74	3260	3	raised	raise	VBN
cord-015021-pol2qm74	3260	4	in	in	IN
cord-015021-pol2qm74	3260	5	9/10	9/10	CD
cord-015021-pol2qm74	3260	6	patients	patient	NNS
cord-015021-pol2qm74	3260	7	(	(	-LRB-
cord-015021-pol2qm74	3260	8	max	max	NNP
cord-015021-pol2qm74	3260	9	level	level	NN
cord-015021-pol2qm74	3260	10	12,500	12,500	CD
cord-015021-pol2qm74	3260	11	pg	pg	NN
cord-015021-pol2qm74	3260	12	/	/	SYM
cord-015021-pol2qm74	3260	13	ml	ml	NN
cord-015021-pol2qm74	3260	14	)	)	-RRB-
cord-015021-pol2qm74	3260	15	but	but	CC
cord-015021-pol2qm74	3260	16	was	be	VBD
cord-015021-pol2qm74	3260	17	unrelated	unrelated	JJ
cord-015021-pol2qm74	3260	18	to	to	IN
cord-015021-pol2qm74	3260	19	condition	condition	NN
cord-015021-pol2qm74	3260	20	or	or	CC
cord-015021-pol2qm74	3260	21	outcome	outcome	NN
cord-015021-pol2qm74	3260	22	.	.	.
cord-015021-pol2qm74	3261	1	5/8	5/8	CD
cord-015021-pol2qm74	3261	2	showed	show	VBD
cord-015021-pol2qm74	3261	3	a	a	DT
cord-015021-pol2qm74	3261	4	rise	rise	NN
cord-015021-pol2qm74	3261	5	in	in	IN
cord-015021-pol2qm74	3261	6	IL-1B	IL-1B	NNP
cord-015021-pol2qm74	3261	7	(	(	-LRB-
cord-015021-pol2qm74	3261	8	max	max	NNP
cord-015021-pol2qm74	3261	9	level	level	NN
cord-015021-pol2qm74	3261	10	90	90	CD
cord-015021-pol2qm74	3261	11	pg	pg	NN
cord-015021-pol2qm74	3261	12	/	/	SYM
cord-015021-pol2qm74	3261	13	ml	ml	NN
cord-015021-pol2qm74	3261	14	)	)	-RRB-
cord-015021-pol2qm74	3261	15	which	which	WDT
cord-015021-pol2qm74	3261	16	was	be	VBD
cord-015021-pol2qm74	3261	17	negatively	negatively	RB
cord-015021-pol2qm74	3261	18	correlated	correlate	VBN
cord-015021-pol2qm74	3261	19	to	to	IN
cord-015021-pol2qm74	3261	20	ISS	ISS	NNP
cord-015021-pol2qm74	3261	21	(	(	-LRB-
cord-015021-pol2qm74	3261	22	I=-0.789	I=-0.789	NNP
cord-015021-pol2qm74	3261	23	,	,	,
cord-015021-pol2qm74	3261	24	p<0.02	p<0.02	XX
cord-015021-pol2qm74	3261	25	)	)	-RRB-
cord-015021-pol2qm74	3261	26	.	.	.
cord-015021-pol2qm74	3262	1	TNFa	TNFa	NNP
cord-015021-pol2qm74	3262	2	was	be	VBD
cord-015021-pol2qm74	3262	3	raised	raise	VBN
cord-015021-pol2qm74	3262	4	in	in	IN
cord-015021-pol2qm74	3262	5	2/10	2/10	CD
cord-015021-pol2qm74	3262	6	(	(	-LRB-
cord-015021-pol2qm74	3262	7	max	max	NNP
cord-015021-pol2qm74	3262	8	level	level	NN
cord-015021-pol2qm74	3262	9	95	95	CD
cord-015021-pol2qm74	3262	10	pg	pg	NN
cord-015021-pol2qm74	3262	11	/	/	SYM
cord-015021-pol2qm74	3262	12	ml	ml	NN
cord-015021-pol2qm74	3262	13	)	)	-RRB-
cord-015021-pol2qm74	3262	14	.	.	.
cord-015021-pol2qm74	3263	1	Peak	Peak	NNP
cord-015021-pol2qm74	3263	2	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	3263	3	was	be	VBD
cord-015021-pol2qm74	3263	4	positively	positively	RB
cord-015021-pol2qm74	3263	5	correlated	correlate	VBN
cord-015021-pol2qm74	3263	6	with	with	IN
cord-015021-pol2qm74	3263	7	ISS	ISS	NNP
cord-015021-pol2qm74	3263	8	(	(	-LRB-
cord-015021-pol2qm74	3263	9	1=0.676	1=0.676	CD
cord-015021-pol2qm74	3263	10	,	,	,
cord-015021-pol2qm74	3263	11	p<0.05	p<0.05	CD
cord-015021-pol2qm74	3263	12	)	)	-RRB-
cord-015021-pol2qm74	3263	13	and	and	CC
cord-015021-pol2qm74	3263	14	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	3263	15	(	(	-LRB-
cord-015021-pol2qm74	3263	16	I=0.602	i=0.602	JJ
cord-015021-pol2qm74	3263	17	but	but	CC
cord-015021-pol2qm74	3263	18	p<0.5	p<0.5	NNP
cord-015021-pol2qm74	3263	19	)	)	-RRB-
cord-015021-pol2qm74	3263	20	.	.	.
cord-015021-pol2qm74	3264	1	IL	IL	NNP
cord-015021-pol2qm74	3264	2	-	-	HYPH
cord-015021-pol2qm74	3264	3	IB	IB	NNP
cord-015021-pol2qm74	3264	4	and	and	CC
cord-015021-pol2qm74	3264	5	TNFa	TNFa	NNP
cord-015021-pol2qm74	3264	6	production	production	NN
cord-015021-pol2qm74	3264	7	was	be	VBD
cord-015021-pol2qm74	3264	8	mutually	mutually	RB
cord-015021-pol2qm74	3264	9	exclusive	exclusive	JJ
cord-015021-pol2qm74	3264	10	.	.	.
cord-015021-pol2qm74	3265	1	There	there	EX
cord-015021-pol2qm74	3265	2	was	be	VBD
cord-015021-pol2qm74	3265	3	no	no	DT
cord-015021-pol2qm74	3265	4	common	common	JJ
cord-015021-pol2qm74	3265	5	cytokine	cytokine	NN
cord-015021-pol2qm74	3265	6	profile	profile	NN
cord-015021-pol2qm74	3265	7	for	for	IN
cord-015021-pol2qm74	3265	8	these	these	DT
cord-015021-pol2qm74	3265	9	patients	patient	NNS
cord-015021-pol2qm74	3265	10	.	.	.
cord-015021-pol2qm74	3266	1	Unlike	unlike	IN
cord-015021-pol2qm74	3266	2	elective	elective	JJ
cord-015021-pol2qm74	3266	3	surgery	surgery	NN
cord-015021-pol2qm74	3266	4	there	there	EX
cord-015021-pol2qm74	3266	5	was	be	VBD
cord-015021-pol2qm74	3266	6	no	no	DT
cord-015021-pol2qm74	3266	7	correlation	correlation	NN
cord-015021-pol2qm74	3266	8	between	between	IN
cord-015021-pol2qm74	3266	9	peak	peak	NN
cord-015021-pol2qm74	3266	10	11,-6	11,-6	CD
cord-015021-pol2qm74	3266	11	and	and	CC
cord-015021-pol2qm74	3266	12	severity	severity	NN
cord-015021-pol2qm74	3266	13	of	of	IN
cord-015021-pol2qm74	3266	14	injury	injury	NN
cord-015021-pol2qm74	3267	1	:	:	:
cord-015021-pol2qm74	3267	2	tissue	tissue	NN
cord-015021-pol2qm74	3267	3	damage	damage	NN
cord-015021-pol2qm74	3267	4	may	may	MD
cord-015021-pol2qm74	3267	5	not	not	RB
cord-015021-pol2qm74	3267	6	be	be	VB
cord-015021-pol2qm74	3267	7	the	the	DT
cord-015021-pol2qm74	3267	8	stimulus	stimulus	NN
cord-015021-pol2qm74	3267	9	for	for	IN
cord-015021-pol2qm74	3267	10	the	the	DT
cord-015021-pol2qm74	3267	11	cytokine	cytokine	NN
cord-015021-pol2qm74	3267	12	response	response	NN
cord-015021-pol2qm74	3267	13	to	to	IN
cord-015021-pol2qm74	3267	14	multiple	multiple	JJ
cord-015021-pol2qm74	3267	15	injury	injury	NN
cord-015021-pol2qm74	3267	16	.	.	.
cord-015021-pol2qm74	3268	1	Periods	period	NNS
cord-015021-pol2qm74	3268	2	of	of	IN
cord-015021-pol2qm74	3268	3	ischemia	ischemia	NN
cord-015021-pol2qm74	3268	4	or	or	CC
cord-015021-pol2qm74	3268	5	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3268	6	produce	produce	VBP
cord-015021-pol2qm74	3268	7	endothelial	endothelial	JJ
cord-015021-pol2qm74	3268	8	damage	damage	NN
cord-015021-pol2qm74	3268	9	in	in	IN
cord-015021-pol2qm74	3268	10	peripheral	peripheral	JJ
cord-015021-pol2qm74	3268	11	organs	organ	NNS
cord-015021-pol2qm74	3268	12	.	.	.
cord-015021-pol2qm74	3269	1	Tumor	tumor	NN
cord-015021-pol2qm74	3269	2	necrosis	necrosis	NN
cord-015021-pol2qm74	3269	3	factor	factor	NN
cord-015021-pol2qm74	3269	4	-	-	HYPH
cord-015021-pol2qm74	3269	5	alpha	alpha	NN
cord-015021-pol2qm74	3269	6	(	(	-LRB-
cord-015021-pol2qm74	3269	7	TNF	TNF	NNP
cord-015021-pol2qm74	3269	8	)	)	-RRB-
cord-015021-pol2qm74	3269	9	plays	play	VBZ
cord-015021-pol2qm74	3269	10	a	a	DT
cord-015021-pol2qm74	3269	11	central	central	JJ
cord-015021-pol2qm74	3269	12	role	role	NN
cord-015021-pol2qm74	3269	13	for	for	IN
cord-015021-pol2qm74	3269	14	regulation	regulation	NN
cord-015021-pol2qm74	3269	15	of	of	IN
cord-015021-pol2qm74	3269	16	endothelial	endothelial	JJ
cord-015021-pol2qm74	3269	17	physiology	physiology	NN
cord-015021-pol2qm74	3269	18	during	during	IN
cord-015021-pol2qm74	3269	19	septic	septic	JJ
cord-015021-pol2qm74	3269	20	events	event	NNS
cord-015021-pol2qm74	3269	21	,	,	,
cord-015021-pol2qm74	3269	22	taking	take	VBG
cord-015021-pol2qm74	3269	23	influence	influence	NN
cord-015021-pol2qm74	3269	24	on	on	IN
cord-015021-pol2qm74	3269	25	vascular	vascular	JJ
cord-015021-pol2qm74	3269	26	permeability	permeability	NN
cord-015021-pol2qm74	3269	27	and	and	CC
cord-015021-pol2qm74	3269	28	coagulant	coagulant	NN
cord-015021-pol2qm74	3269	29	activity	activity	NN
cord-015021-pol2qm74	3269	30	[	[	-LRB-
cord-015021-pol2qm74	3269	31	1	1	CD
cord-015021-pol2qm74	3269	32	]	]	-RRB-
cord-015021-pol2qm74	3269	33	.	.	.
cord-015021-pol2qm74	3270	1	Animal	animal	NN
cord-015021-pol2qm74	3270	2	experiments	experiment	NNS
cord-015021-pol2qm74	3270	3	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	3270	4	a	a	DT
cord-015021-pol2qm74	3270	5	synergism	synergism	NN
cord-015021-pol2qm74	3270	6	between	between	IN
cord-015021-pol2qm74	3270	7	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3270	8	and	and	CC
cord-015021-pol2qm74	3270	9	septic	septic	JJ
cord-015021-pol2qm74	3270	10	shock	shock	NN
cord-015021-pol2qm74	3270	11	on	on	IN
cord-015021-pol2qm74	3270	12	letality	letality	NN
cord-015021-pol2qm74	3270	13	,	,	,
cord-015021-pol2qm74	3270	14	leading	lead	VBG
cord-015021-pol2qm74	3270	15	to	to	IN
cord-015021-pol2qm74	3270	16	the	the	DT
cord-015021-pol2qm74	3270	17	hypothesis	hypothesis	NN
cord-015021-pol2qm74	3270	18	that	that	IN
cord-015021-pol2qm74	3270	19	low	low	JJ
cord-015021-pol2qm74	3270	20	oxygen	oxygen	NN
cord-015021-pol2qm74	3270	21	tension	tension	NN
cord-015021-pol2qm74	3270	22	leads	lead	VBZ
cord-015021-pol2qm74	3270	23	to	to	IN
cord-015021-pol2qm74	3270	24	enhanced	enhanced	JJ
cord-015021-pol2qm74	3270	25	sensitivity	sensitivity	NN
cord-015021-pol2qm74	3270	26	of	of	IN
cord-015021-pol2qm74	3270	27	target	target	NN
cord-015021-pol2qm74	3270	28	cells	cell	NNS
cord-015021-pol2qm74	3270	29	for	for	IN
cord-015021-pol2qm74	3270	30	TNF	TNF	NNP
cord-015021-pol2qm74	3270	31	[	[	-LRB-
cord-015021-pol2qm74	3270	32	2	2	CD
cord-015021-pol2qm74	3270	33	]	]	-RRB-
cord-015021-pol2qm74	3270	34	.	.	.
cord-015021-pol2qm74	3271	1	Radioligand	radioligand	JJ
cord-015021-pol2qm74	3271	2	binding	binding	JJ
cord-015021-pol2qm74	3271	3	studies	study	NNS
cord-015021-pol2qm74	3271	4	with	with	IN
cord-015021-pol2qm74	3271	5	~261odid	~261odid	NNP
cord-015021-pol2qm74	3271	6	-	-	HYPH
cord-015021-pol2qm74	3271	7	TNF	TNF	NNP
cord-015021-pol2qm74	3271	8	on	on	IN
cord-015021-pol2qm74	3271	9	cultured	cultured	JJ
cord-015021-pol2qm74	3271	10	human	human	JJ
cord-015021-pol2qm74	3271	11	endothelial	endothelial	JJ
cord-015021-pol2qm74	3271	12	cells	cell	NNS
cord-015021-pol2qm74	3271	13	were	be	VBD
cord-015021-pol2qm74	3271	14	performed	perform	VBN
cord-015021-pol2qm74	3271	15	after	after	IN
cord-015021-pol2qm74	3271	16	incubation	incubation	NN
cord-015021-pol2qm74	3271	17	in	in	IN
cord-015021-pol2qm74	3271	18	several	several	JJ
cord-015021-pol2qm74	3271	19	environmental	environmental	JJ
cord-015021-pol2qm74	3271	20	oxygen	oxygen	NN
cord-015021-pol2qm74	3271	21	tensions	tension	NNS
cord-015021-pol2qm74	3271	22	(	(	-LRB-
cord-015021-pol2qm74	3271	23	PC2	PC2	NNP
cord-015021-pol2qm74	3271	24	)	)	-RRB-
cord-015021-pol2qm74	3271	25	for	for	IN
cord-015021-pol2qm74	3271	26	12	12	CD
cord-015021-pol2qm74	3271	27	hours	hour	NNS
cord-015021-pol2qm74	3271	28	.	.	.
cord-015021-pol2qm74	3272	1	Data	datum	NNS
cord-015021-pol2qm74	3272	2	were	be	VBD
cord-015021-pol2qm74	3272	3	achieved	achieve	VBN
cord-015021-pol2qm74	3272	4	by	by	IN
cord-015021-pol2qm74	3272	5	nonlinear	nonlinear	JJ
cord-015021-pol2qm74	3272	6	regression	regression	NN
cord-015021-pol2qm74	3272	7	of	of	IN
cord-015021-pol2qm74	3272	8	an	an	DT
cord-015021-pol2qm74	3272	9	idealized	idealized	JJ
cord-015021-pol2qm74	3272	10	saturation	saturation	NN
cord-015021-pol2qm74	3272	11	curve	curve	NN
cord-015021-pol2qm74	3272	12	according	accord	VBG
cord-015021-pol2qm74	3272	13	to	to	IN
cord-015021-pol2qm74	3272	14	the	the	DT
cord-015021-pol2qm74	3272	15	equation	equation	NN
cord-015021-pol2qm74	3272	16	:	:	:
cord-015021-pol2qm74	3273	1	B	b	NN
cord-015021-pol2qm74	3273	2	=	=	SYM
cord-015021-pol2qm74	3273	3	n	n	NN
cord-015021-pol2qm74	3273	4	"	"	``
cord-015021-pol2qm74	3273	5	K./(1	k./(1	NN
cord-015021-pol2qm74	3274	1	+	+	CC
cord-015021-pol2qm74	3274	2	K	K	NNP
cord-015021-pol2qm74	3274	3	,	,	,
cord-015021-pol2qm74	3274	4	)	)	-RRB-
cord-015021-pol2qm74	3274	5	;	;	:
cord-015021-pol2qm74	3274	6	B	b	NN
cord-015021-pol2qm74	3274	7	=	=	NFP
cord-015021-pol2qm74	3274	8	totally	totally	RB
cord-015021-pol2qm74	3274	9	bound	bind	VBN
cord-015021-pol2qm74	3274	10	TNF	TNF	NNP
cord-015021-pol2qm74	3274	11	;	;	:
cord-015021-pol2qm74	3274	12	K	K	NNP
cord-015021-pol2qm74	3274	13	,	,	,
cord-015021-pol2qm74	3274	14	:	:	:
cord-015021-pol2qm74	3274	15	association	association	NN
cord-015021-pol2qm74	3274	16	constant	constant	NN
cord-015021-pol2qm74	3274	17	(	(	-LRB-
cord-015021-pol2qm74	3274	18	concentration	concentration	NN
cord-015021-pol2qm74	3274	19	for	for	IN
cord-015021-pol2qm74	3274	20	half	half	RB
cord-015021-pol2qm74	3274	21	-	-	HYPH
cord-015021-pol2qm74	3274	22	maximal	maximal	JJ
cord-015021-pol2qm74	3274	23	binding	binding	NN
cord-015021-pol2qm74	3274	24	)	)	-RRB-
cord-015021-pol2qm74	3274	25	;	;	:
cord-015021-pol2qm74	3274	26	n	n	CC
cord-015021-pol2qm74	3274	27	:	:	:
cord-015021-pol2qm74	3274	28	number	number	NN
cord-015021-pol2qm74	3274	29	of	of	IN
cord-015021-pol2qm74	3274	30	binding	bind	VBG
cord-015021-pol2qm74	3274	31	sites	site	NNS
cord-015021-pol2qm74	3274	32	per	per	IN
cord-015021-pol2qm74	3274	33	cell	cell	NN
cord-015021-pol2qm74	3274	34	.	.	.
cord-015021-pol2qm74	3275	1	p_O0o	p_O0o	NFP
cord-015021-pol2qm74	3276	1	(	(	-LRB-
cord-015021-pol2qm74	3276	2	mm	mm	NNP
cord-015021-pol2qm74	3277	1	H¢I	h¢i	LS
cord-015021-pol2qm74	3277	2	)	)	-RRB-
cord-015021-pol2qm74	3277	3	:	:	:
cord-015021-pol2qm74	3278	1	_	_	NNP
cord-015021-pol2qm74	3278	2	K	K	NNP
cord-015021-pol2qm74	3278	3	,	,	,
cord-015021-pol2qm74	3278	4	(	(	-LRB-
cord-015021-pol2qm74	3278	5	nM	nm	NN
cord-015021-pol2qm74	3278	6	}	}	-RRB-
cord-015021-pol2qm74	3278	7	:	:	:
cord-015021-pol2qm74	3278	8	n	n	LS
cord-015021-pol2qm74	3278	9	(	(	-LRB-
cord-015021-pol2qm74	3278	10	molecules	molecule	NNS
cord-015021-pol2qm74	3278	11	/	/	SYM
cord-015021-pol2qm74	3278	12	cell	cell	NN
cord-015021-pol2qm74	3278	13	)	)	-RRB-
cord-015021-pol2qm74	3278	14	:	:	:
cord-015021-pol2qm74	3278	15	130	130	CD
cord-015021-pol2qm74	3278	16	-150	-150	NN
cord-015021-pol2qm74	3278	17	1.83	1.83	CD
cord-015021-pol2qm74	3278	18	±	±	CD
cord-015021-pol2qm74	3278	19	0.15	0.15	CD
cord-015021-pol2qm74	3278	20	2600	2600	CD
cord-015021-pol2qm74	3279	1	_	_	NNP
cord-015021-pol2qm74	3279	2	+	+	CC
cord-015021-pol2qm74	3280	1	500	500	CD
cord-015021-pol2qm74	3280	2	55	55	CD
cord-015021-pol2qm74	3280	3	-70	-70	NN
cord-015021-pol2qm74	3280	4	1.27	1.27	CD
cord-015021-pol2qm74	3280	5	±	±	NN
cord-015021-pol2qm74	3281	1	0.15	0.15	CD
cord-015021-pol2qm74	3281	2	3600	3600	CD
cord-015021-pol2qm74	3281	3	+	+	SYM
cord-015021-pol2qm74	3281	4	500	500	CD
cord-015021-pol2qm74	3281	5	25	25	CD
cord-015021-pol2qm74	3282	1	-35	-35	NNP
cord-015021-pol2qm74	3282	2	0,41	0,41	ADD
cord-015021-pol2qm74	3283	1	±	±	CD
cord-015021-pol2qm74	3283	2	0.13	0.13	CD
cord-015021-pol2qm74	3283	3	4800	4800	CD
cord-015021-pol2qm74	3284	1	-+	-+	.
cord-015021-pol2qm74	3285	1	500	500	CD
cord-015021-pol2qm74	3285	2	10	10	CD
cord-015021-pol2qm74	3285	3	-	-	SYM
cord-015021-pol2qm74	3285	4	15	15	CD
cord-015021-pol2qm74	3285	5	0.18	0.18	CD
cord-015021-pol2qm74	3285	6	+	+	CD
cord-015021-pol2qm74	3285	7	0.07	0.07	CD
cord-015021-pol2qm74	3285	8	5900	5900	CD
cord-015021-pol2qm74	3286	1	-+	-+	NNP
cord-015021-pol2qm74	3286	2	300	300	CD
cord-015021-pol2qm74	3286	3	Presented	present	VBN
cord-015021-pol2qm74	3286	4	are	be	VBP
cord-015021-pol2qm74	3286	5	calculated	calculate	VBN
cord-015021-pol2qm74	3286	6	values	value	NNS
cord-015021-pol2qm74	3286	7	on	on	IN
cord-015021-pol2qm74	3286	8	the	the	DT
cord-015021-pol2qm74	3286	9	idealized	idealized	JJ
cord-015021-pol2qm74	3286	10	curve	curve	NN
cord-015021-pol2qm74	3286	11	+	+	CC
cord-015021-pol2qm74	3286	12	95	95	CD
cord-015021-pol2qm74	3286	13	%	%	NN
cord-015021-pol2qm74	3286	14	percentiles	percentile	NNS
cord-015021-pol2qm74	3286	15	.	.	.
cord-015021-pol2qm74	3287	1	Hypoxia	hypoxia	NN
cord-015021-pol2qm74	3287	2	induces	induce	VBZ
cord-015021-pol2qm74	3287	3	enhanced	enhance	VBN
cord-015021-pol2qm74	3287	4	binding	binding	NN
cord-015021-pol2qm74	3287	5	of	of	IN
cord-015021-pol2qm74	3287	6	TNF	TNF	NNP
cord-015021-pol2qm74	3287	7	to	to	TO
cord-015021-pol2qm74	3287	8	specific	specific	JJ
cord-015021-pol2qm74	3287	9	receptors	receptor	NNS
cord-015021-pol2qm74	3287	10	on	on	IN
cord-015021-pol2qm74	3287	11	the	the	DT
cord-015021-pol2qm74	3287	12	endothelial	endothelial	JJ
cord-015021-pol2qm74	3287	13	cell	cell	NN
cord-015021-pol2qm74	3287	14	surface	surface	NN
cord-015021-pol2qm74	3287	15	in	in	IN
cord-015021-pol2qm74	3287	16	a	a	DT
cord-015021-pol2qm74	3287	17	time	time	NN
cord-015021-pol2qm74	3287	18	-	-	:
cord-015021-pol2qm74	3287	19	and	and	CC
cord-015021-pol2qm74	3287	20	dose	dose	NN
cord-015021-pol2qm74	3287	21	-	-	HYPH
cord-015021-pol2qm74	3287	22	dependent	dependent	JJ
cord-015021-pol2qm74	3287	23	manner	manner	NN
cord-015021-pol2qm74	3287	24	by	by	IN
cord-015021-pol2qm74	3287	25	a	a	DT
cord-015021-pol2qm74	3287	26	mechanism	mechanism	NN
cord-015021-pol2qm74	3287	27	,	,	,
cord-015021-pol2qm74	3287	28	which	which	WDT
cord-015021-pol2qm74	3287	29	is	be	VBZ
cord-015021-pol2qm74	3287	30	not	not	RB
cord-015021-pol2qm74	3287	31	dependent	dependent	JJ
cord-015021-pol2qm74	3287	32	on	on	IN
cord-015021-pol2qm74	3287	33	oxygen	oxygen	NN
cord-015021-pol2qm74	3287	34	radicals	radical	NNS
cord-015021-pol2qm74	3287	35	,	,	,
cord-015021-pol2qm74	3287	36	as	as	IN
cord-015021-pol2qm74	3287	37	shown	show	VBN
cord-015021-pol2qm74	3287	38	by	by	IN
cord-015021-pol2qm74	3287	39	additional	additional	JJ
cord-015021-pol2qm74	3287	40	protocols	protocol	NNS
cord-015021-pol2qm74	3287	41	with	with	IN
cord-015021-pol2qm74	3287	42	radical	radical	JJ
cord-015021-pol2qm74	3287	43	-	-	HYPH
cord-015021-pol2qm74	3287	44	scavenging	scavenge	VBG
cord-015021-pol2qm74	3287	45	drugs	drug	NNS
cord-015021-pol2qm74	3287	46	.	.	.
cord-015021-pol2qm74	3288	1	With	with	IN
cord-015021-pol2qm74	3288	2	respect	respect	NN
cord-015021-pol2qm74	3288	3	to	to	IN
cord-015021-pol2qm74	3288	4	former	former	JJ
cord-015021-pol2qm74	3288	5	findings	finding	NNS
cord-015021-pol2qm74	3288	6	about	about	IN
cord-015021-pol2qm74	3288	7	a	a	DT
cord-015021-pol2qm74	3288	8	correlation	correlation	NN
cord-015021-pol2qm74	3288	9	between	between	IN
cord-015021-pol2qm74	3288	10	growth	growth	NN
cord-015021-pol2qm74	3288	11	and	and	CC
cord-015021-pol2qm74	3288	12	TNF	TNF	NNP
cord-015021-pol2qm74	3288	13	receptor	receptor	NN
cord-015021-pol2qm74	3288	14	affinity	affinity	NN
cord-015021-pol2qm74	3288	15	[	[	-LRB-
cord-015021-pol2qm74	3288	16	3	3	CD
cord-015021-pol2qm74	3288	17	]	]	-RRB-
cord-015021-pol2qm74	3288	18	,	,	,
cord-015021-pol2qm74	3288	19	these	these	DT
cord-015021-pol2qm74	3288	20	data	datum	NNS
cord-015021-pol2qm74	3288	21	lead	lead	VBP
cord-015021-pol2qm74	3288	22	to	to	IN
cord-015021-pol2qm74	3288	23	the	the	DT
cord-015021-pol2qm74	3288	24	hypothesis	hypothesis	NN
cord-015021-pol2qm74	3288	25	that	that	WDT
cord-015021-pol2qm74	3288	26	enhanced	enhance	VBD
cord-015021-pol2qm74	3288	27	TNF	TNF	NNP
cord-015021-pol2qm74	3288	28	binding	bind	VBG
cord-015021-pol2qm74	3288	29	during	during	IN
cord-015021-pol2qm74	3288	30	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3288	31	is	be	VBZ
cord-015021-pol2qm74	3288	32	due	due	JJ
cord-015021-pol2qm74	3288	33	to	to	IN
cord-015021-pol2qm74	3288	34	a	a	DT
cord-015021-pol2qm74	3288	35	biochemical	biochemical	JJ
cord-015021-pol2qm74	3288	36	conversion	conversion	NN
cord-015021-pol2qm74	3288	37	of	of	IN
cord-015021-pol2qm74	3288	38	the	the	DT
cord-015021-pol2qm74	3288	39	receptor	receptor	NN
cord-015021-pol2qm74	3288	40	protein	protein	NN
cord-015021-pol2qm74	3288	41	from	from	IN
cord-015021-pol2qm74	3288	42	the	the	DT
cord-015021-pol2qm74	3288	43	low	low	JJ
cord-015021-pol2qm74	3288	44	affinity	affinity	NN
cord-015021-pol2qm74	3288	45	to	to	IN
cord-015021-pol2qm74	3288	46	the	the	DT
cord-015021-pol2qm74	3288	47	high	high	JJ
cord-015021-pol2qm74	3288	48	affinity	affinity	NN
cord-015021-pol2qm74	3288	49	state	state	NN
cord-015021-pol2qm74	3288	50	,	,	,
cord-015021-pol2qm74	3288	51	possibly	possibly	RB
cord-015021-pol2qm74	3288	52	by	by	IN
cord-015021-pol2qm74	3288	53	posttranslational	posttranslational	JJ
cord-015021-pol2qm74	3288	54	phosphorylation	phosphorylation	NN
cord-015021-pol2qm74	3288	55	of	of	IN
cord-015021-pol2qm74	3288	56	the	the	DT
cord-015021-pol2qm74	3288	57	binding	bind	VBG
cord-015021-pol2qm74	3288	58	protein	protein	NN
cord-015021-pol2qm74	3288	59	by	by	IN
cord-015021-pol2qm74	3288	60	intracel)ular	intracel)ular	NNP
cord-015021-pol2qm74	3288	61	kinases	kinase	NNS
cord-015021-pol2qm74	3288	62	.	.	.
cord-015021-pol2qm74	3289	1	The	the	DT
cord-015021-pol2qm74	3289	2	proposed	propose	VBN
cord-015021-pol2qm74	3289	3	involvement	involvement	NN
cord-015021-pol2qm74	3289	4	of	of	IN
cord-015021-pol2qm74	3289	5	TNF	TNF	NNP
cord-015021-pol2qm74	3289	6	-	-	HYPH
cord-015021-pol2qm74	3289	7	dependent	dependent	JJ
cord-015021-pol2qm74	3289	8	pathways	pathway	NNS
cord-015021-pol2qm74	3289	9	in	in	IN
cord-015021-pol2qm74	3289	10	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	3289	11	of	of	IN
cord-015021-pol2qm74	3289	12	organ	organ	NN
cord-015021-pol2qm74	3289	13	dysfunction	dysfunction	NN
cord-015021-pol2qm74	3289	14	and	and	CC
cord-015021-pol2qm74	3289	15	multiple	multiple	JJ
cord-015021-pol2qm74	3289	16	organ	organ	NN
cord-015021-pol2qm74	3289	17	failure	failure	NN
cord-015021-pol2qm74	3289	18	after	after	IN
cord-015021-pol2qm74	3289	19	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3289	20	/	/	SYM
cord-015021-pol2qm74	3289	21	ischemia	ischemia	NN
cord-015021-pol2qm74	3289	22	may	may	MD
cord-015021-pol2qm74	3289	23	provide	provide	VB
cord-015021-pol2qm74	3289	24	a	a	DT
cord-015021-pol2qm74	3289	25	basis	basis	NN
cord-015021-pol2qm74	3289	26	for	for	IN
cord-015021-pol2qm74	3289	27	understanding	understand	VBG
cord-015021-pol2qm74	3289	28	the	the	DT
cord-015021-pol2qm74	3289	29	initiation	initiation	NN
cord-015021-pol2qm74	3289	30	of	of	IN
cord-015021-pol2qm74	3289	31	hypoxic	hypoxic	JJ
cord-015021-pol2qm74	3289	32	vascular	vascular	JJ
cord-015021-pol2qm74	3289	33	injury	injury	NN
cord-015021-pol2qm74	3289	34	,	,	,
cord-015021-pol2qm74	3289	35	as	as	IN
cord-015021-pol2qm74	3289	36	manifested	manifest	VBN
cord-015021-pol2qm74	3289	37	by	by	IN
cord-015021-pol2qm74	3289	38	increased	increase	VBN
cord-015021-pol2qm74	3289	39	permeability	permeability	NN
cord-015021-pol2qm74	3289	40	and	and	CC
cord-015021-pol2qm74	3289	41	prothrombotic	prothrombotic	JJ
cord-015021-pol2qm74	3289	42	tendency	tendency	NN
cord-015021-pol2qm74	3289	43	,	,	,
cord-015021-pol2qm74	3289	44	and	and	CC
cord-015021-pol2qm74	3289	45	,	,	,
cord-015021-pol2qm74	3289	46	thus	thus	RB
cord-015021-pol2qm74	3289	47	,	,	,
cord-015021-pol2qm74	3289	48	merits	merit	NNS
cord-015021-pol2qm74	3289	49	further	further	JJ
cord-015021-pol2qm74	3289	50	attention	attention	NN
cord-015021-pol2qm74	3289	51	.	.	.
cord-015021-pol2qm74	3290	1	The	the	DT
cord-015021-pol2qm74	3290	2	levels	level	NNS
cord-015021-pol2qm74	3290	3	of	of	IN
cord-015021-pol2qm74	3290	4	activity	activity	NN
cord-015021-pol2qm74	3290	5	of	of	IN
cord-015021-pol2qm74	3290	6	circulating	circulate	VBG
cord-015021-pol2qm74	3290	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	3290	8	(	(	-LRB-
cord-015021-pol2qm74	3290	9	ILl	ILl	NNP
cord-015021-pol2qm74	3290	10	,	,	,
cord-015021-pol2qm74	3290	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	3290	12	and	and	CC
cord-015021-pol2qm74	3290	13	TNF	TNF	NNP
cord-015021-pol2qm74	3290	14	-	-	HYPH
cord-015021-pol2qm74	3290	15	alpha	alpha	NN
cord-015021-pol2qm74	3290	16	)	)	-RRB-
cord-015021-pol2qm74	3290	17	which	which	WDT
cord-015021-pol2qm74	3290	18	are	be	VBP
cord-015021-pol2qm74	3290	19	believed	believe	VBN
cord-015021-pol2qm74	3290	20	to	to	TO
cord-015021-pol2qm74	3290	21	play	play	VB
cord-015021-pol2qm74	3290	22	important	important	JJ
cord-015021-pol2qm74	3290	23	regulatory	regulatory	JJ
cord-015021-pol2qm74	3290	24	role	role	NN
cord-015021-pol2qm74	3290	25	in	in	IN
cord-015021-pol2qm74	3290	26	response	response	NN
cord-015021-pol2qm74	3290	27	to	to	IN
cord-015021-pol2qm74	3290	28	trauma	trauma	NN
cord-015021-pol2qm74	3290	29	are	be	VBP
cord-015021-pol2qm74	3290	30	determined	determine	VBN
cord-015021-pol2qm74	3290	31	(	(	-LRB-
cord-015021-pol2qm74	3290	32	by	by	IN
cord-015021-pol2qm74	3290	33	hioassays	hioassay	NNS
cord-015021-pol2qm74	3290	34	and	and	CC
cord-015021-pol2qm74	3290	35	respective	respective	JJ
cord-015021-pol2qm74	3290	36	anti	anti	JJ
cord-015021-pol2qm74	3290	37	-	-	JJ
cord-015021-pol2qm74	3290	38	cytokine	cytokine	JJ
cord-015021-pol2qm74	3290	39	antibodies	antibody	NNS
cord-015021-pol2qm74	3290	40	)	)	-RRB-
cord-015021-pol2qm74	3290	41	in	in	IN
cord-015021-pol2qm74	3290	42	mice	mouse	NNS
cord-015021-pol2qm74	3290	43	and	and	CC
cord-015021-pol2qm74	3290	44	rats	rat	NNS
cord-015021-pol2qm74	3290	45	subjected	subject	VBN
cord-015021-pol2qm74	3290	46	to	to	TO
cord-015021-pol2qm74	3290	47	scald	scald	VB
cord-015021-pol2qm74	3290	48	injury	injury	NN
cord-015021-pol2qm74	3290	49	ion	ion	NN
cord-015021-pol2qm74	3290	50	C,10	C,10	NNP
cord-015021-pol2qm74	3290	51	see	see	VB
cord-015021-pol2qm74	3290	52	,	,	,
cord-015021-pol2qm74	3290	53	°	°	NN
cord-015021-pol2qm74	3290	54	0v	0v	NN
cord-015021-pol2qm74	3290	55	BSA	BSA	NNP
cord-015021-pol2qm74	3290	56	,	,	,
cord-015021-pol2qm74	3290	57	LD	LD	NNP
cord-015021-pol2qm74	3290	58	50	50	CD
cord-015021-pol2qm74	3290	59	)	)	-RRB-
cord-015021-pol2qm74	3290	60	and	and	CC
cord-015021-pol2qm74	3290	61	(	(	-LRB-
cord-015021-pol2qm74	3290	62	80	80	CD
cord-015021-pol2qm74	3290	63	C	C	NNP
cord-015021-pol2qm74	3290	64	,	,	,
cord-015021-pol2qm74	3290	65	30	30	CD
cord-015021-pol2qm74	3290	66	see	see	VB
cord-015021-pol2qm74	3290	67	,	,	,
cord-015021-pol2qm74	3290	68	20	20	CD
cord-015021-pol2qm74	3290	69	~	~	NFP
cord-015021-pol2qm74	3291	1	B	B	NNP
cord-015021-pol2qm74	3291	2	~^)~	~^)~	NNP
cord-015021-pol2qm74	3291	3	,	,	,
cord-015021-pol2qm74	3291	4	respectively	respectively	RB
cord-015021-pol2qm74	3291	5	.	.	.
cord-015021-pol2qm74	3292	1	Biphasic	Biphasic	NNP
cord-015021-pol2qm74	3292	2	increase	increase	NN
cord-015021-pol2qm74	3292	3	of	of	IN
cord-015021-pol2qm74	3292	4	cytokine	cytokine	NN
cord-015021-pol2qm74	3292	5	activity	activity	NN
cord-015021-pol2qm74	3292	6	was	be	VBD
cord-015021-pol2qm74	3292	7	noted	note	VBN
cord-015021-pol2qm74	3292	8	in	in	IN
cord-015021-pol2qm74	3292	9	mice	mouse	NNS
cord-015021-pol2qm74	3292	10	:	:	:
cord-015021-pol2qm74	3292	11	initial	initial	JJ
cord-015021-pol2qm74	3292	12	increase	increase	NN
cord-015021-pol2qm74	3292	13	of	of	IN
cord-015021-pol2qm74	3292	14	IL	IL	NNP
cord-015021-pol2qm74	3292	15	-	-	:
cord-015021-pol2qm74	3292	16	I	I	NNP
cord-015021-pol2qm74	3292	17	and	and	CC
cord-015021-pol2qm74	3292	18	IL-6	IL-6	NNP
cord-015021-pol2qm74	3292	19	,	,	,
cord-015021-pol2qm74	3292	20	1	1	CD
cord-015021-pol2qm74	3292	21	-	-	SYM
cord-015021-pol2qm74	3292	22	3	3	CD
cord-015021-pol2qm74	3292	23	hr	hr	NN
cord-015021-pol2qm74	3292	24	following	follow	VBG
cord-015021-pol2qm74	3292	25	injury	injury	NN
cord-015021-pol2qm74	3292	26	and	and	CC
cord-015021-pol2qm74	3292	27	of	of	IN
cord-015021-pol2qm74	3292	28	TRY	try	NN
cord-015021-pol2qm74	3292	29	activity	activity	NN
cord-015021-pol2qm74	3292	30	6hr	6hr	NN
cord-015021-pol2qm74	3292	31	after	after	IN
cord-015021-pol2qm74	3292	32	scald	scald	NN
cord-015021-pol2qm74	3292	33	,	,	,
cord-015021-pol2qm74	3292	34	followed	follow	VBN
cord-015021-pol2qm74	3292	35	by	by	IN
cord-015021-pol2qm74	3292	36	elevated	elevated	JJ
cord-015021-pol2qm74	3292	37	levels	level	NNS
cord-015021-pol2qm74	3292	38	of	of	IN
cord-015021-pol2qm74	3292	39	IL	IL	NNP
cord-015021-pol2qm74	3292	40	-	-	:
cord-015021-pol2qm74	3292	41	I	I	NNP
cord-015021-pol2qm74	3292	42	and	and	CC
cord-015021-pol2qm74	3292	43	IL-6	IL-6	NNP
cord-015021-pol2qm74	3292	44	at	at	IN
cord-015021-pol2qm74	3292	45	12hr	12hr	NNP
cord-015021-pol2qm74	3292	46	,	,	,
cord-015021-pol2qm74	3292	47	with	with	IN
cord-015021-pol2qm74	3292	48	tendency	tendency	NN
cord-015021-pol2qm74	3292	49	of	of	IN
cord-015021-pol2qm74	3292	50	decrease	decrease	NN
cord-015021-pol2qm74	3292	51	of	of	IN
cord-015021-pol2qm74	3292	52	activity	activity	NN
cord-015021-pol2qm74	3292	53	at	at	IN
cord-015021-pol2qm74	3292	54	later	later	JJ
cord-015021-pol2qm74	3292	55	time	time	NN
cord-015021-pol2qm74	3292	56	points	point	NNS
cord-015021-pol2qm74	3292	57	.	.	.
cord-015021-pol2qm74	3293	1	Increased	increase	VBN
cord-015021-pol2qm74	3293	2	activity	activity	NN
cord-015021-pol2qm74	3293	3	of	of	IN
cord-015021-pol2qm74	3293	4	TNF	TNF	NNP
cord-015021-pol2qm74	3293	5	was	be	VBD
cord-015021-pol2qm74	3293	6	noted	note	VBN
cord-015021-pol2qm74	3293	7	24	24	CD
cord-015021-pol2qm74	3293	8	hr	hr	NN
cord-015021-pol2qm74	3293	9	following	follow	VBG
cord-015021-pol2qm74	3293	10	injury	injury	NN
cord-015021-pol2qm74	3293	11	,	,	,
cord-015021-pol2qm74	3294	1	In	in	IN
cord-015021-pol2qm74	3294	2	rats	rat	NNS
cord-015021-pol2qm74	3294	3	,	,	,
cord-015021-pol2qm74	3294	4	initial	initial	JJ
cord-015021-pol2qm74	3294	5	,	,	,
cord-015021-pol2qm74	3294	6	short	short	RB
cord-015021-pol2qm74	3294	7	-	-	HYPH
cord-015021-pol2qm74	3294	8	lived	live	VBN
cord-015021-pol2qm74	3294	9	increase	increase	NN
cord-015021-pol2qm74	3294	10	of	of	IN
cord-015021-pol2qm74	3294	11	IL	IL	NNP
cord-015021-pol2qm74	3294	12	-	-	HYPH
cord-015021-pol2qm74	3294	13	i	i	NNP
cord-015021-pol2qm74	3294	14	and	and	CC
cord-015021-pol2qm74	3294	15	TNF	TNF	NNP
cord-015021-pol2qm74	3294	16	activity	activity	NN
cord-015021-pol2qm74	3294	17	was	be	VBD
cord-015021-pol2qm74	3294	18	detected	detect	VBN
cord-015021-pol2qm74	3294	19	lhr	lhr	NNP
cord-015021-pol2qm74	3294	20	following	follow	VBG
cord-015021-pol2qm74	3294	21	injury	injury	NN
cord-015021-pol2qm74	3294	22	,	,	,
cord-015021-pol2qm74	3294	23	folowed	folowe	VBN
cord-015021-pol2qm74	3294	24	by	by	IN
cord-015021-pol2qm74	3294	25	increase	increase	NN
cord-015021-pol2qm74	3294	26	on	on	IN
cord-015021-pol2qm74	3294	27	days	day	NNS
cord-015021-pol2qm74	3294	28	I	-PRON-	PRP
cord-015021-pol2qm74	3294	29	and	and	CC
cord-015021-pol2qm74	3294	30	3	3	CD
cord-015021-pol2qm74	3294	31	postburn	postburn	NN
cord-015021-pol2qm74	3294	32	.	.	.
cord-015021-pol2qm74	3295	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3295	2	increase	increase	NN
cord-015021-pol2qm74	3295	3	peaked	peak	VBD
cord-015021-pol2qm74	3295	4	3	3	CD
cord-015021-pol2qm74	3295	5	-	-	SYM
cord-015021-pol2qm74	3295	6	12	12	CD
cord-015021-pol2qm74	3295	7	hr	hr	NN
cord-015021-pol2qm74	3295	8	after	after	IN
cord-015021-pol2qm74	3295	9	scalding	scald	VBG
cord-015021-pol2qm74	3295	10	and	and	CC
cord-015021-pol2qm74	3295	11	levels	level	NNS
cord-015021-pol2qm74	3295	12	remained	remain	VBD
cord-015021-pol2qm74	3295	13	elevated	elevated	JJ
cord-015021-pol2qm74	3295	14	3	3	CD
cord-015021-pol2qm74	3295	15	-	-	SYM
cord-015021-pol2qm74	3295	16	5	5	CD
cord-015021-pol2qm74	3295	17	days	day	NNS
cord-015021-pol2qm74	3295	18	following	follow	VBG
cord-015021-pol2qm74	3295	19	injury	injury	NN
cord-015021-pol2qm74	3295	20	.	.	.
cord-015021-pol2qm74	3296	1	Similar	similar	JJ
cord-015021-pol2qm74	3296	2	kinetics	kinetic	NNS
cord-015021-pol2qm74	3296	3	of	of	IN
cord-015021-pol2qm74	3296	4	appearance	appearance	NN
cord-015021-pol2qm74	3296	5	of	of	IN
cord-015021-pol2qm74	3296	6	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3296	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	3296	8	(	(	-LRB-
cord-015021-pol2qm74	3296	9	IL	IL	NNP
cord-015021-pol2qm74	3296	10	-	-	HYPH
cord-015021-pol2qm74	3296	11	I	I	NNP
cord-015021-pol2qm74	3296	12	and	and	CC
cord-015021-pol2qm74	3296	13	TNF	TNF	NNP
cord-015021-pol2qm74	3296	14	-	-	HYPH
cord-015021-pol2qm74	3296	15	alpha	alpha	NN
cord-015021-pol2qm74	3296	16	)	)	-RRB-
cord-015021-pol2qm74	3296	17	both	both	CC
cord-015021-pol2qm74	3296	18	in	in	IN
cord-015021-pol2qm74	3296	19	lethal	lethal	JJ
cord-015021-pol2qm74	3296	20	and	and	CC
cord-015021-pol2qm74	3296	21	ncnlethal	ncnlethal	JJ
cord-015021-pol2qm74	3296	22	injury	injury	NN
cord-015021-pol2qm74	3296	23	concomitant	concomitant	JJ
cord-015021-pol2qm74	3296	24	with	with	IN
cord-015021-pol2qm74	3296	25	differential	differential	JJ
cord-015021-pol2qm74	3296	26	profile	profile	NN
cord-015021-pol2qm74	3296	27	of	of	IN
cord-015021-pol2qm74	3296	28	circulating	circulate	VBG
cord-015021-pol2qm74	3296	29	IL-6	IL-6	NNP
cord-015021-pol2qm74	3296	30	activity	activity	NN
cord-015021-pol2qm74	3296	31	(	(	-LRB-
cord-015021-pol2qm74	3296	32	early	early	JJ
cord-015021-pol2qm74	3296	33	,	,	,
cord-015021-pol2qm74	3296	34	short	short	RB
cord-015021-pol2qm74	3296	35	-	-	HYPH
cord-015021-pol2qm74	3296	36	lived	live	VBN
cord-015021-pol2qm74	3296	37	increase	increase	NN
cord-015021-pol2qm74	3296	38	and	and	CC
cord-015021-pol2qm74	3296	39	later	later	RBR
cord-015021-pol2qm74	3296	40	slow	slow	JJ
cord-015021-pol2qm74	3296	41	decrease	decrease	NN
cord-015021-pol2qm74	3296	42	of	of	IN
cord-015021-pol2qm74	3296	43	activity	activity	NN
cord-015021-pol2qm74	3296	44	in	in	IN
cord-015021-pol2qm74	3296	45	lethal	lethal	JJ
cord-015021-pol2qm74	3296	46	burn	burn	NN
cord-015021-pol2qm74	3296	47	injury	injury	NN
cord-015021-pol2qm74	3296	48	)	)	-RRB-
cord-015021-pol2qm74	3296	49	with	with	IN
cord-015021-pol2qm74	3296	50	late	late	JJ
cord-015021-pol2qm74	3296	51	persistent	persistent	JJ
cord-015021-pol2qm74	3296	52	high	high	JJ
cord-015021-pol2qm74	3296	53	levels	level	NNS
cord-015021-pol2qm74	3296	54	of	of	IN
cord-015021-pol2qm74	3296	55	activity	activity	NN
cord-015021-pol2qm74	3296	56	in	in	IN
cord-015021-pol2qm74	3296	57	nonlethai	nonlethai	NNP
cord-015021-pol2qm74	3296	58	injury	injury	NN
cord-015021-pol2qm74	3296	59	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3296	60	in	in	IN
cord-015021-pol2qm74	3296	61	the	the	DT
cord-015021-pol2qm74	3296	62	present	present	JJ
cord-015021-pol2qm74	3296	63	study	study	NN
cord-015021-pol2qm74	3296	64	highlight	highlight	VBP
cord-015021-pol2qm74	3296	65	the	the	DT
cord-015021-pol2qm74	3296	66	need	need	NN
cord-015021-pol2qm74	3296	67	for	for	IN
cord-015021-pol2qm74	3296	68	investigation	investigation	NN
cord-015021-pol2qm74	3296	69	the	the	DT
cord-015021-pol2qm74	3296	70	relationship	relationship	NN
cord-015021-pol2qm74	3296	71	of	of	IN
cord-015021-pol2qm74	3296	72	these	these	DT
cord-015021-pol2qm74	3296	73	cytokines	cytokine	NNS
cord-015021-pol2qm74	3296	74	in	in	IN
cord-015021-pol2qm74	3296	75	burn	burn	NN
cord-015021-pol2qm74	3296	76	-	-	HYPH
cord-015021-pol2qm74	3296	77	injury	injury	NN
cord-015021-pol2qm74	3296	78	induced	induce	VBN
cord-015021-pol2qm74	3296	79	inflammation	inflammation	NN
cord-015021-pol2qm74	3296	80	.	.	.
cord-015021-pol2qm74	3297	1	Zikica	Zikica	NNP
cord-015021-pol2qm74	3297	2	Jovicic	Jovicic	NNP
cord-015021-pol2qm74	3297	3	,	,	,
cord-015021-pol2qm74	3297	4	lnstitute	lnstitute	NN
cord-015021-pol2qm74	3297	5	for	for	IN
cord-015021-pol2qm74	3297	6	Medical	Medical	NNP
cord-015021-pol2qm74	3297	7	Research	Research	NNP
cord-015021-pol2qm74	3297	8	,	,	,
cord-015021-pol2qm74	3297	9	MMA	MMA	NNP
cord-015021-pol2qm74	3297	10	,	,	,
cord-015021-pol2qm74	3297	11	Crnotravska	Crnotravska	NNP
cord-015021-pol2qm74	3297	12	17,11002	17,11002	CD
cord-015021-pol2qm74	3297	13	Belgrade	Belgrade	NNP
cord-015021-pol2qm74	3297	14	~	~	NFP
cord-015021-pol2qm74	3297	15	Yu	Yu	NNP
cord-015021-pol2qm74	3297	16	.	.	.
cord-015021-pol2qm74	3298	1	Asadullah	Asadullah	NNP
cord-015021-pol2qm74	3298	2	K	K	NNP
cord-015021-pol2qm74	3298	3	(	(	-LRB-
cord-015021-pol2qm74	3298	4	1	1	CD
cord-015021-pol2qm74	3298	5	)	)	-RRB-
cord-015021-pol2qm74	3298	6	,	,	,
cord-015021-pol2qm74	3298	7	Woiciechowsky	Woiciechowsky	NNP
cord-015021-pol2qm74	3298	8	C	C	NNP
cord-015021-pol2qm74	3298	9	(	(	-LRB-
cord-015021-pol2qm74	3298	10	2	2	CD
cord-015021-pol2qm74	3298	11	)	)	-RRB-
cord-015021-pol2qm74	3298	12	,	,	,
cord-015021-pol2qm74	3298	13	LiebenthaI	liebenthai	FW
cord-015021-pol2qm74	3298	14	C	C	NNP
cord-015021-pol2qm74	3298	15	(	(	-LRB-
cord-015021-pol2qm74	3298	16	1	1	CD
cord-015021-pol2qm74	3298	17	)	)	-RRB-
cord-015021-pol2qm74	3298	18	,	,	,
cord-015021-pol2qm74	3298	19	Doecke	Doecke	NNP
cord-015021-pol2qm74	3298	20	WD	WD	NNP
cord-015021-pol2qm74	3298	21	(	(	-LRB-
cord-015021-pol2qm74	3298	22	1	1	CD
cord-015021-pol2qm74	3298	23	)	)	-RRB-
cord-015021-pol2qm74	3298	24	,	,	,
cord-015021-pol2qm74	3298	25	Volk	Volk	NNP
cord-015021-pol2qm74	3298	26	HD	HD	NNP
cord-015021-pol2qm74	3298	27	(	(	-LRB-
cord-015021-pol2qm74	3298	28	1	1	CD
cord-015021-pol2qm74	3298	29	)	)	-RRB-
cord-015021-pol2qm74	3298	30	,	,	,
cord-015021-pol2qm74	3298	31	Vogel	Vogel	NNP
cord-015021-pol2qm74	3298	32	S	S	NNP
cord-015021-pol2qm74	3298	33	(	(	-LRB-
cord-015021-pol2qm74	3298	34	2	2	CD
cord-015021-pol2qm74	3298	35	)	)	-RRB-
cord-015021-pol2qm74	3298	36	,	,	,
cord-015021-pol2qm74	3298	37	v.	v.	CC
cord-015021-pol2qm74	3298	38	Baehr	Baehr	NNP
cord-015021-pol2qm74	3298	39	R	R	NNP
cord-015021-pol2qm74	3298	40	(	(	-LRB-
cord-015021-pol2qm74	3298	41	1	1	CD
cord-015021-pol2qm74	3298	42	)	)	-RRB-
cord-015021-pol2qm74	3298	43	;	;	:
cord-015021-pol2qm74	3298	44	Depts	Depts	NNPS
cord-015021-pol2qm74	3298	45	.	.	.
cord-015021-pol2qm74	3299	1	of	of	IN
cord-015021-pol2qm74	3299	2	Med	Med	NNP
cord-015021-pol2qm74	3299	3	.	.	.
cord-015021-pol2qm74	3299	4	Immunology	Immunology	NNP
cord-015021-pol2qm74	3299	5	(	(	-LRB-
cord-015021-pol2qm74	3299	6	1	1	CD
cord-015021-pol2qm74	3299	7	)	)	-RRB-
cord-015021-pol2qm74	3299	8	and	and	CC
cord-015021-pol2qm74	3299	9	Neurosurgery	Neurosurgery	NNP
cord-015021-pol2qm74	3299	10	(	(	-LRB-
cord-015021-pol2qm74	3299	11	2	2	CD
cord-015021-pol2qm74	3299	12	)	)	-RRB-
cord-015021-pol2qm74	3299	13	,	,	,
cord-015021-pol2qm74	3299	14	Medical	Medical	NNP
cord-015021-pol2qm74	3299	15	School	School	NNP
cord-015021-pol2qm74	3299	16	(	(	-LRB-
cord-015021-pol2qm74	3299	17	Char#d	Char#d	NNP
cord-015021-pol2qm74	3299	18	)	)	-RRB-
cord-015021-pol2qm74	3299	19	,	,	,
cord-015021-pol2qm74	3299	20	Humboldt	Humboldt	NNP
cord-015021-pol2qm74	3299	21	University	University	NNP
cord-015021-pol2qm74	3299	22	Berlin	Berlin	NNP
cord-015021-pol2qm74	3299	23	,	,	,
cord-015021-pol2qm74	3299	24	FRG	FRG	NNP
cord-015021-pol2qm74	3300	1	In	in	IN
cord-015021-pol2qm74	3300	2	patients	patient	NNS
cord-015021-pol2qm74	3300	3	after	after	IN
cord-015021-pol2qm74	3300	4	polytrauma	polytrauma	NN
cord-015021-pol2qm74	3300	5	or	or	CC
cord-015021-pol2qm74	3300	6	major	major	JJ
cord-015021-pol2qm74	3300	7	abdominal	abdominal	JJ
cord-015021-pol2qm74	3300	8	surgery	surgery	NN
cord-015021-pol2qm74	3300	9	a	a	DT
cord-015021-pol2qm74	3300	10	hyperinflammatory	hyperinflammatory	JJ
cord-015021-pol2qm74	3300	11	phase	phase	NN
cord-015021-pol2qm74	3300	12	seems	seem	VBZ
cord-015021-pol2qm74	3300	13	to	to	TO
cord-015021-pol2qm74	3300	14	be	be	VB
cord-015021-pol2qm74	3300	15	followed	follow	VBN
cord-015021-pol2qm74	3300	16	by	by	IN
cord-015021-pol2qm74	3300	17	the	the	DT
cord-015021-pol2qm74	3300	18	development	development	NN
cord-015021-pol2qm74	3300	19	of	of	IN
cord-015021-pol2qm74	3300	20	a	a	DT
cord-015021-pol2qm74	3300	21	phase	phase	NN
cord-015021-pol2qm74	3300	22	of	of	IN
cord-015021-pol2qm74	3300	23	monocyte	monocyte	NNP
cord-015021-pol2qm74	3300	24	inactivation	inactivation	NN
cord-015021-pol2qm74	3300	25	.	.	.
cord-015021-pol2qm74	3301	1	The	the	DT
cord-015021-pol2qm74	3301	2	latter	latter	JJ
cord-015021-pol2qm74	3301	3	is	be	VBZ
cord-015021-pol2qm74	3301	4	charaeterised	charaeterise	VBN
cord-015021-pol2qm74	3301	5	by	by	IN
cord-015021-pol2qm74	3301	6	a	a	DT
cord-015021-pol2qm74	3301	7	decrease	decrease	NN
cord-015021-pol2qm74	3301	8	of	of	IN
cord-015021-pol2qm74	3301	9	monocytic	monocytic	JJ
cord-015021-pol2qm74	3301	10	HLA	HLA	NNP
cord-015021-pol2qm74	3301	11	-	-	HYPH
cord-015021-pol2qm74	3301	12	DR	DR	NNP
cord-015021-pol2qm74	3301	13	expression	expression	NN
cord-015021-pol2qm74	3301	14	and	and	CC
cord-015021-pol2qm74	3301	15	a	a	DT
cord-015021-pol2qm74	3301	16	shift	shift	NN
cord-015021-pol2qm74	3301	17	to	to	IN
cord-015021-pol2qm74	3301	18	anti	anti	JJ
cord-015021-pol2qm74	3301	19	-	-	JJ
cord-015021-pol2qm74	3301	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3301	21	cytokine	cytokine	NN
cord-015021-pol2qm74	3301	22	production	production	NN
cord-015021-pol2qm74	3301	23	.	.	.
cord-015021-pol2qm74	3302	1	As	as	IN
cord-015021-pol2qm74	3302	2	shown	show	VBN
cord-015021-pol2qm74	3302	3	,	,	,
cord-015021-pol2qm74	3302	4	by	by	IN
cord-015021-pol2qm74	3302	5	us	-PRON-	PRP
cord-015021-pol2qm74	3302	6	and	and	CC
cord-015021-pol2qm74	3302	7	others	other	NNS
cord-015021-pol2qm74	3302	8	,	,	,
cord-015021-pol2qm74	3302	9	this	this	DT
cord-015021-pol2qm74	3302	10	phenomenon	phenomenon	NN
cord-015021-pol2qm74	3302	11	indicates	indicate	VBZ
cord-015021-pol2qm74	3302	12	severe	severe	JJ
cord-015021-pol2qm74	3302	13	immunodepression	immunodepression	NN
cord-015021-pol2qm74	3302	14	with	with	IN
cord-015021-pol2qm74	3302	15	a	a	DT
cord-015021-pol2qm74	3302	16	high	high	JJ
cord-015021-pol2qm74	3302	17	risk	risk	NN
cord-015021-pol2qm74	3302	18	of	of	IN
cord-015021-pol2qm74	3302	19	infection	infection	NN
cord-015021-pol2qm74	3302	20	.	.	.
cord-015021-pol2qm74	3303	1	However	however	RB
cord-015021-pol2qm74	3303	2	,	,	,
cord-015021-pol2qm74	3303	3	the	the	DT
cord-015021-pol2qm74	3303	4	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3303	5	leading	lead	VBG
cord-015021-pol2qm74	3303	6	to	to	IN
cord-015021-pol2qm74	3303	7	monocyte	monocyte	NNP
cord-015021-pol2qm74	3303	8	inactivation	inactivation	NN
cord-015021-pol2qm74	3303	9	in	in	IN
cord-015021-pol2qm74	3303	10	the	the	DT
cord-015021-pol2qm74	3303	11	above	above	RB
cord-015021-pol2qm74	3303	12	mentioned	mention	VBN
cord-015021-pol2qm74	3303	13	syndromes	syndrome	NNS
cord-015021-pol2qm74	3303	14	may	may	MD
cord-015021-pol2qm74	3303	15	be	be	VB
cord-015021-pol2qm74	3303	16	multiple	multiple	JJ
cord-015021-pol2qm74	3303	17	.	.	.
cord-015021-pol2qm74	3304	1	To	to	TO
cord-015021-pol2qm74	3304	2	elucidate	elucidate	VB
cord-015021-pol2qm74	3304	3	the	the	DT
cord-015021-pol2qm74	3304	4	influence	influence	NN
cord-015021-pol2qm74	3304	5	of	of	IN
cord-015021-pol2qm74	3304	6	a	a	DT
cord-015021-pol2qm74	3304	7	selective	selective	JJ
cord-015021-pol2qm74	3304	8	,	,	,
cord-015021-pol2qm74	3304	9	sterile	sterile	JJ
cord-015021-pol2qm74	3304	10	trauma	trauma	NN
cord-015021-pol2qm74	3304	11	to	to	IN
cord-015021-pol2qm74	3304	12	the	the	DT
cord-015021-pol2qm74	3304	13	central	central	JJ
cord-015021-pol2qm74	3304	14	nervous	nervous	JJ
cord-015021-pol2qm74	3304	15	system	system	NN
cord-015021-pol2qm74	3304	16	(	(	-LRB-
cord-015021-pol2qm74	3304	17	CNS	CNS	NNP
cord-015021-pol2qm74	3304	18	)	)	-RRB-
cord-015021-pol2qm74	3304	19	on	on	IN
cord-015021-pol2qm74	3304	20	immune	immune	JJ
cord-015021-pol2qm74	3304	21	reactivity	reactivity	NN
cord-015021-pol2qm74	3304	22	the	the	DT
cord-015021-pol2qm74	3304	23	neurosurgieal	neurosurgieal	NN
cord-015021-pol2qm74	3304	24	patient	patient	NN
cord-015021-pol2qm74	3304	25	is	be	VBZ
cord-015021-pol2qm74	3304	26	an	an	DT
cord-015021-pol2qm74	3304	27	interesting	interesting	JJ
cord-015021-pol2qm74	3304	28	model	model	NN
cord-015021-pol2qm74	3304	29	.	.	.
cord-015021-pol2qm74	3305	1	Initially	initially	RB
cord-015021-pol2qm74	3305	2	,	,	,
cord-015021-pol2qm74	3305	3	30	30	CD
cord-015021-pol2qm74	3305	4	patients	patient	NNS
cord-015021-pol2qm74	3305	5	who	who	WP
cord-015021-pol2qm74	3305	6	developed	develop	VBD
cord-015021-pol2qm74	3305	7	a	a	DT
cord-015021-pol2qm74	3305	8	systemic	systemic	JJ
cord-015021-pol2qm74	3305	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3305	10	response	response	NN
cord-015021-pol2qm74	3305	11	syndrome	syndrome	NN
cord-015021-pol2qm74	3305	12	following	follow	VBG
cord-015021-pol2qm74	3305	13	neurosurgery	neurosurgery	NNP
cord-015021-pol2qm74	3305	14	were	be	VBD
cord-015021-pol2qm74	3305	15	analysed	analyse	VBN
cord-015021-pol2qm74	3305	16	.	.	.
cord-015021-pol2qm74	3306	1	In	in	IN
cord-015021-pol2qm74	3306	2	all	all	DT
cord-015021-pol2qm74	3306	3	of	of	IN
cord-015021-pol2qm74	3306	4	them	-PRON-	PRP
cord-015021-pol2qm74	3306	5	a	a	DT
cord-015021-pol2qm74	3306	6	marked	marked	JJ
cord-015021-pol2qm74	3306	7	decrease	decrease	NN
cord-015021-pol2qm74	3306	8	of	of	IN
cord-015021-pol2qm74	3306	9	monocytic	monocytic	JJ
cord-015021-pol2qm74	3306	10	HLA	HLA	NNP
cord-015021-pol2qm74	3306	11	-	-	HYPH
cord-015021-pol2qm74	3306	12	DR	DR	NNP
cord-015021-pol2qm74	3306	13	expression	expression	NN
cord-015021-pol2qm74	3306	14	was	be	VBD
cord-015021-pol2qm74	3306	15	observed	observe	VBN
cord-015021-pol2qm74	3306	16	soon	soon	RB
cord-015021-pol2qm74	3306	17	after	after	IN
cord-015021-pol2qm74	3306	18	the	the	DT
cord-015021-pol2qm74	3306	19	operation	operation	NN
cord-015021-pol2qm74	3306	20	.	.	.
cord-015021-pol2qm74	3307	1	These	these	DT
cord-015021-pol2qm74	3307	2	results	result	NNS
cord-015021-pol2qm74	3307	3	suggest	suggest	VBP
cord-015021-pol2qm74	3307	4	that	that	IN
cord-015021-pol2qm74	3307	5	neurosurgery	neurosurgery	NN
cord-015021-pol2qm74	3307	6	alone	alone	RB
cord-015021-pol2qm74	3307	7	can	can	MD
cord-015021-pol2qm74	3307	8	induce	induce	VB
cord-015021-pol2qm74	3307	9	immunodepression	immunodepression	NN
cord-015021-pol2qm74	3307	10	and	and	CC
cord-015021-pol2qm74	3307	11	lead	lead	VB
cord-015021-pol2qm74	3307	12	us	-PRON-	PRP
cord-015021-pol2qm74	3307	13	to	to	TO
cord-015021-pol2qm74	3307	14	conduct	conduct	VB
cord-015021-pol2qm74	3307	15	a	a	DT
cord-015021-pol2qm74	3307	16	prospective	prospective	JJ
cord-015021-pol2qm74	3307	17	study	study	NN
cord-015021-pol2qm74	3307	18	,	,	,
cord-015021-pol2qm74	3307	19	in	in	IN
cord-015021-pol2qm74	3307	20	which	which	WDT
cord-015021-pol2qm74	3307	21	we	-PRON-	PRP
cord-015021-pol2qm74	3307	22	closely	closely	RB
cord-015021-pol2qm74	3307	23	monitored	monitor	VBD
cord-015021-pol2qm74	3307	24	l0	l0	NNP
cord-015021-pol2qm74	3307	25	patients	patient	NNS
cord-015021-pol2qm74	3307	26	undergoing	undergo	VBG
cord-015021-pol2qm74	3307	27	neurosurgery	neurosurgery	NN
cord-015021-pol2qm74	3307	28	from	from	IN
cord-015021-pol2qm74	3307	29	the	the	DT
cord-015021-pol2qm74	3307	30	first	first	JJ
cord-015021-pol2qm74	3307	31	preoperative	preoperative	JJ
cord-015021-pol2qm74	3307	32	day	day	NN
cord-015021-pol2qm74	3307	33	until	until	IN
cord-015021-pol2qm74	3307	34	at	at	IN
cord-015021-pol2qm74	3307	35	least	least	JJS
cord-015021-pol2qm74	3307	36	day	day	NN
cord-015021-pol2qm74	3307	37	6	6	CD
cord-015021-pol2qm74	3307	38	after	after	IN
cord-015021-pol2qm74	3307	39	the	the	DT
cord-015021-pol2qm74	3307	40	operation	operation	NN
cord-015021-pol2qm74	3307	41	.	.	.
cord-015021-pol2qm74	3308	1	HLA	HLA	NNP
cord-015021-pol2qm74	3308	2	-	-	HYPH
cord-015021-pol2qm74	3308	3	DR	DR	NNP
cord-015021-pol2qm74	3308	4	expression	expression	NN
cord-015021-pol2qm74	3308	5	was	be	VBD
cord-015021-pol2qm74	3308	6	decreased	decrease	VBN
cord-015021-pol2qm74	3308	7	hi	hi	UH
cord-015021-pol2qm74	3308	8	all	all	DT
cord-015021-pol2qm74	3308	9	patients	patient	NNS
cord-015021-pol2qm74	3308	10	to	to	IN
cord-015021-pol2qm74	3308	11	various	various	JJ
cord-015021-pol2qm74	3308	12	extent	extent	NN
cord-015021-pol2qm74	3308	13	only	only	RB
cord-015021-pol2qm74	3308	14	hours	hour	NNS
cord-015021-pol2qm74	3308	15	after	after	IN
cord-015021-pol2qm74	3308	16	surgery	surgery	NN
cord-015021-pol2qm74	3308	17	.	.	.
cord-015021-pol2qm74	3309	1	In	in	IN
cord-015021-pol2qm74	3309	2	one	one	CD
cord-015021-pol2qm74	3309	3	patient	patient	NN
cord-015021-pol2qm74	3309	4	only	only	RB
cord-015021-pol2qm74	3309	5	we	-PRON-	PRP
cord-015021-pol2qm74	3309	6	found	find	VBD
cord-015021-pol2qm74	3309	7	a	a	DT
cord-015021-pol2qm74	3309	8	persistently	persistently	RB
cord-015021-pol2qm74	3309	9	reduced	reduce	VBN
cord-015021-pol2qm74	3309	10	HLA	HLA	NNP
cord-015021-pol2qm74	3309	11	-	-	HYPH
cord-015021-pol2qm74	3309	12	DR	DR	NNP
cord-015021-pol2qm74	3309	13	expression	expression	NN
cord-015021-pol2qm74	3309	14	and	and	CC
cord-015021-pol2qm74	3309	15	this	this	DT
cord-015021-pol2qm74	3309	16	was	be	VBD
cord-015021-pol2qm74	3309	17	the	the	DT
cord-015021-pol2qm74	3309	18	only	only	JJ
cord-015021-pol2qm74	3309	19	patient	patient	NN
cord-015021-pol2qm74	3309	20	to	to	TO
cord-015021-pol2qm74	3309	21	develop	develop	VB
cord-015021-pol2qm74	3309	22	sepsis	sepsis	NN
cord-015021-pol2qm74	3309	23	syndrome	syndrome	NN
cord-015021-pol2qm74	3309	24	.	.	.
cord-015021-pol2qm74	3310	1	This	this	DT
cord-015021-pol2qm74	3310	2	suggests	suggest	VBZ
cord-015021-pol2qm74	3310	3	that	that	IN
cord-015021-pol2qm74	3310	4	a	a	DT
cord-015021-pol2qm74	3310	5	prolonged	prolonged	JJ
cord-015021-pol2qm74	3310	6	,	,	,
cord-015021-pol2qm74	3310	7	postoperatively	postoperatively	RB
cord-015021-pol2qm74	3310	8	decreased	decrease	VBD
cord-015021-pol2qm74	3310	9	HLA	HLA	NNP
cord-015021-pol2qm74	3310	10	-	-	HYPH
cord-015021-pol2qm74	3310	11	DR	DR	NNP
cord-015021-pol2qm74	3310	12	expression	expression	NN
cord-015021-pol2qm74	3310	13	is	be	VBZ
cord-015021-pol2qm74	3310	14	predictive	predictive	JJ
cord-015021-pol2qm74	3310	15	of	of	IN
cord-015021-pol2qm74	3310	16	infection	infection	NN
cord-015021-pol2qm74	3310	17	following	follow	VBG
cord-015021-pol2qm74	3310	18	CNS	CNS	NNP
cord-015021-pol2qm74	3310	19	trauma	trauma	NN
cord-015021-pol2qm74	3310	20	.	.	.
cord-015021-pol2qm74	3311	1	In	in	IN
cord-015021-pol2qm74	3311	2	order	order	NN
cord-015021-pol2qm74	3311	3	to	to	TO
cord-015021-pol2qm74	3311	4	assess	assess	VB
cord-015021-pol2qm74	3311	5	,	,	,
cord-015021-pol2qm74	3311	6	whether	whether	IN
cord-015021-pol2qm74	3311	7	a	a	DT
cord-015021-pol2qm74	3311	8	decrease	decrease	NN
cord-015021-pol2qm74	3311	9	of	of	IN
cord-015021-pol2qm74	3311	10	HLA	HLA	NNP
cord-015021-pol2qm74	3311	11	-	-	HYPH
cord-015021-pol2qm74	3311	12	DR	DR	NNP
cord-015021-pol2qm74	3311	13	expression	expression	NN
cord-015021-pol2qm74	3311	14	was	be	VBD
cord-015021-pol2qm74	3311	15	associated	associate	VBN
cord-015021-pol2qm74	3311	16	with	with	IN
cord-015021-pol2qm74	3311	17	a	a	DT
cord-015021-pol2qm74	3311	18	preceding	precede	VBG
cord-015021-pol2qm74	3311	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3311	20	response	response	NN
cord-015021-pol2qm74	3311	21	,	,	,
cord-015021-pol2qm74	3311	22	local	local	JJ
cord-015021-pol2qm74	3311	23	cytokine	cytokine	NN
cord-015021-pol2qm74	3311	24	release	release	NN
cord-015021-pol2qm74	3311	25	in	in	IN
cord-015021-pol2qm74	3311	26	the	the	DT
cord-015021-pol2qm74	3311	27	CNS	CNS	NNP
cord-015021-pol2qm74	3311	28	was	be	VBD
cord-015021-pol2qm74	3311	29	compared	compare	VBN
cord-015021-pol2qm74	3311	30	with	with	IN
cord-015021-pol2qm74	3311	31	systemic	systemic	JJ
cord-015021-pol2qm74	3311	32	cytokine	cytokine	NN
cord-015021-pol2qm74	3311	33	release	release	NN
cord-015021-pol2qm74	3311	34	.	.	.
cord-015021-pol2qm74	3312	1	For	for	IN
cord-015021-pol2qm74	3312	2	this	this	DT
cord-015021-pol2qm74	3312	3	purpose	purpose	NN
cord-015021-pol2qm74	3312	4	,	,	,
cord-015021-pol2qm74	3312	5	paired	pair	VBD
cord-015021-pol2qm74	3312	6	samples	sample	NNS
cord-015021-pol2qm74	3312	7	of	of	IN
cord-015021-pol2qm74	3312	8	earebrospinal	earebrospinal	JJ
cord-015021-pol2qm74	3312	9	fluid	fluid	NN
cord-015021-pol2qm74	3312	10	(	(	-LRB-
cord-015021-pol2qm74	3312	11	CSF	CSF	NNP
cord-015021-pol2qm74	3312	12	)	)	-RRB-
cord-015021-pol2qm74	3312	13	from	from	IN
cord-015021-pol2qm74	3312	14	a	a	DT
cord-015021-pol2qm74	3312	15	vantricle	vantricle	NN
cord-015021-pol2qm74	3312	16	drainage	drainage	NN
cord-015021-pol2qm74	3312	17	and	and	CC
cord-015021-pol2qm74	3312	18	peripheral	peripheral	JJ
cord-015021-pol2qm74	3312	19	blood	blood	NN
cord-015021-pol2qm74	3312	20	plasma	plasma	NN
cord-015021-pol2qm74	3312	21	were	be	VBD
cord-015021-pol2qm74	3312	22	obtained	obtain	VBN
cord-015021-pol2qm74	3312	23	.	.	.
cord-015021-pol2qm74	3313	1	In	in	IN
cord-015021-pol2qm74	3313	2	the	the	DT
cord-015021-pol2qm74	3313	3	CSF	CSF	NNP
cord-015021-pol2qm74	3313	4	extremely	extremely	RB
cord-015021-pol2qm74	3313	5	elevated	elevate	VBN
cord-015021-pol2qm74	3313	6	futerleakin	futerleakin	NN
cord-015021-pol2qm74	3313	7	(	(	-LRB-
cord-015021-pol2qm74	3313	8	IL)-6	IL)-6	NNP
cord-015021-pol2qm74	3313	9	levels	level	NNS
cord-015021-pol2qm74	3313	10	,	,	,
cord-015021-pol2qm74	3313	11	peaking	peak	VBG
cord-015021-pol2qm74	3313	12	already	already	RB
cord-015021-pol2qm74	3313	13	a	a	DT
cord-015021-pol2qm74	3313	14	few	few	JJ
cord-015021-pol2qm74	3313	15	hours	hour	NNS
cord-015021-pol2qm74	3313	16	after	after	IN
cord-015021-pol2qm74	3313	17	the	the	DT
cord-015021-pol2qm74	3313	18	operation	operation	NN
cord-015021-pol2qm74	3313	19	were	be	VBD
cord-015021-pol2qm74	3313	20	found	find	VBN
cord-015021-pol2qm74	3313	21	.	.	.
cord-015021-pol2qm74	3314	1	In	in	IN
cord-015021-pol2qm74	3314	2	plasma	plasma	NN
cord-015021-pol2qm74	3314	3	,	,	,
cord-015021-pol2qm74	3314	4	by	by	IN
cord-015021-pol2qm74	3314	5	eontrast	eontrast	NNP
cord-015021-pol2qm74	3314	6	,	,	,
cord-015021-pol2qm74	3314	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	3314	8	(	(	-LRB-
cord-015021-pol2qm74	3314	9	and	and	CC
cord-015021-pol2qm74	3314	10	TNF	tnf	NN
cord-015021-pol2qm74	3314	11	-	-	HYPH
cord-015021-pol2qm74	3314	12	alpha	alpha	NN
cord-015021-pol2qm74	3314	13	)	)	-RRB-
cord-015021-pol2qm74	3314	14	was	be	VBD
cord-015021-pol2qm74	3314	15	detectable	detectable	JJ
cord-015021-pol2qm74	3314	16	not	not	RB
cord-015021-pol2qm74	3314	17	until	until	IN
cord-015021-pol2qm74	3314	18	days	day	NNS
cord-015021-pol2qm74	3314	19	later	later	RB
cord-015021-pol2qm74	3314	20	and	and	CC
cord-015021-pol2qm74	3314	21	only	only	RB
cord-015021-pol2qm74	3314	22	if	if	IN
cord-015021-pol2qm74	3314	23	infection	infection	NN
cord-015021-pol2qm74	3314	24	was	be	VBD
cord-015021-pol2qm74	3314	25	present	present	JJ
cord-015021-pol2qm74	3314	26	.	.	.
cord-015021-pol2qm74	3315	1	The	the	DT
cord-015021-pol2qm74	3315	2	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	3315	3	ILI	ILI	NNP
cord-015021-pol2qm74	3315	4	-	-	HYPH
cord-015021-pol2qm74	3315	5	RA	RA	NNP
cord-015021-pol2qm74	3315	6	,	,	,
cord-015021-pol2qm74	3315	7	on	on	IN
cord-015021-pol2qm74	3315	8	the	the	DT
cord-015021-pol2qm74	3315	9	other	other	JJ
cord-015021-pol2qm74	3315	10	hand	hand	NN
cord-015021-pol2qm74	3315	11	,	,	,
cord-015021-pol2qm74	3315	12	was	be	VBD
cord-015021-pol2qm74	3315	13	also	also	RB
cord-015021-pol2qm74	3315	14	present	present	JJ
cord-015021-pol2qm74	3315	15	in	in	IN
cord-015021-pol2qm74	3315	16	CSF	CSF	NNP
cord-015021-pol2qm74	3315	17	but	but	CC
cord-015021-pol2qm74	3315	18	peaked	peak	VBD
cord-015021-pol2qm74	3315	19	after	after	IN
cord-015021-pol2qm74	3315	20	IL-6	IL-6	NNP
cord-015021-pol2qm74	3315	21	and	and	CC
cord-015021-pol2qm74	3315	22	was	be	VBD
cord-015021-pol2qm74	3315	23	detectable	detectable	JJ
cord-015021-pol2qm74	3315	24	in	in	IN
cord-015021-pol2qm74	3315	25	peripheral	peripheral	JJ
cord-015021-pol2qm74	3315	26	plasma	plasma	NN
cord-015021-pol2qm74	3315	27	too	too	RB
cord-015021-pol2qm74	3315	28	.	.	.
cord-015021-pol2qm74	3316	1	We	-PRON-	PRP
cord-015021-pol2qm74	3316	2	believe	believe	VBP
cord-015021-pol2qm74	3316	3	there	there	EX
cord-015021-pol2qm74	3316	4	is	be	VBZ
cord-015021-pol2qm74	3316	5	an	an	DT
cord-015021-pol2qm74	3316	6	association	association	NN
cord-015021-pol2qm74	3316	7	between	between	IN
cord-015021-pol2qm74	3316	8	the	the	DT
cord-015021-pol2qm74	3316	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3316	10	response	response	NN
cord-015021-pol2qm74	3316	11	in	in	IN
cord-015021-pol2qm74	3316	12	the	the	DT
cord-015021-pol2qm74	3316	13	CNS	CNS	NNP
cord-015021-pol2qm74	3316	14	and	and	CC
cord-015021-pol2qm74	3316	15	the	the	DT
cord-015021-pol2qm74	3316	16	following	follow	VBG
cord-015021-pol2qm74	3316	17	depression	depression	NN
cord-015021-pol2qm74	3316	18	of	of	IN
cord-015021-pol2qm74	3316	19	HLA	HLA	NNP
cord-015021-pol2qm74	3316	20	-	-	HYPH
cord-015021-pol2qm74	3316	21	DR	DR	NNP
cord-015021-pol2qm74	3316	22	expression	expression	NN
cord-015021-pol2qm74	3316	23	on	on	IN
cord-015021-pol2qm74	3316	24	peripheral	peripheral	JJ
cord-015021-pol2qm74	3316	25	blood	blood	NN
cord-015021-pol2qm74	3316	26	monocytes	monocyte	NNS
cord-015021-pol2qm74	3316	27	.	.	.
cord-015021-pol2qm74	3317	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3317	2	results	result	NNS
cord-015021-pol2qm74	3317	3	suggest	suggest	VBP
cord-015021-pol2qm74	3317	4	that	that	IN
cord-015021-pol2qm74	3317	5	even	even	RB
cord-015021-pol2qm74	3317	6	a	a	DT
cord-015021-pol2qm74	3317	7	sterile	sterile	JJ
cord-015021-pol2qm74	3317	8	CNS	CNS	NNP
cord-015021-pol2qm74	3317	9	-	-	HYPH
cord-015021-pol2qm74	3317	10	trauma	trauma	NN
cord-015021-pol2qm74	3317	11	by	by	IN
cord-015021-pol2qm74	3317	12	itself	-PRON-	PRP
cord-015021-pol2qm74	3317	13	may	may	MD
cord-015021-pol2qm74	3317	14	contribute	contribute	VB
cord-015021-pol2qm74	3317	15	to	to	IN
cord-015021-pol2qm74	3317	16	general	general	NNP
cord-015021-pol2qm74	3317	17	immunodepressinn	immunodepressinn	NNP
cord-015021-pol2qm74	3317	18	leading	lead	VBG
cord-015021-pol2qm74	3317	19	to	to	IN
cord-015021-pol2qm74	3317	20	septic	septic	JJ
cord-015021-pol2qm74	3317	21	complications	complication	NNS
cord-015021-pol2qm74	3317	22	.	.	.
cord-015021-pol2qm74	3318	1	The	the	DT
cord-015021-pol2qm74	3318	2	aim	aim	NN
cord-015021-pol2qm74	3318	3	of	of	IN
cord-015021-pol2qm74	3318	4	this	this	DT
cord-015021-pol2qm74	3318	5	study	study	NN
cord-015021-pol2qm74	3318	6	was	be	VBD
cord-015021-pol2qm74	3318	7	to	to	TO
cord-015021-pol2qm74	3318	8	evaluate	evaluate	VB
cord-015021-pol2qm74	3318	9	the	the	DT
cord-015021-pol2qm74	3318	10	effect	effect	NN
cord-015021-pol2qm74	3318	11	of	of	IN
cord-015021-pol2qm74	3318	12	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	3318	13	shock	shock	NN
cord-015021-pol2qm74	3318	14	(	(	-LRB-
cord-015021-pol2qm74	3318	15	HS	HS	NNP
cord-015021-pol2qm74	3318	16	)	)	-RRB-
cord-015021-pol2qm74	3318	17	a	a	LS
cord-015021-pol2qm74	3318	18	)	)	-RRB-
cord-015021-pol2qm74	3318	19	on	on	IN
cord-015021-pol2qm74	3318	20	total	total	JJ
cord-015021-pol2qm74	3318	21	capacity	capacity	NN
cord-015021-pol2qm74	3318	22	of	of	IN
cord-015021-pol2qm74	3318	23	the	the	DT
cord-015021-pol2qm74	3318	24	host	host	NN
cord-015021-pol2qm74	3318	25	,	,	,
cord-015021-pol2qm74	3318	26	and	and	CC
cord-015021-pol2qm74	3318	27	b	b	LS
cord-015021-pol2qm74	3318	28	)	)	-RRB-
cord-015021-pol2qm74	3318	29	the	the	DT
cord-015021-pol2qm74	3318	30	circulating	circulate	VBG
cord-015021-pol2qm74	3318	31	blood	blood	NN
cord-015021-pol2qm74	3318	32	cells	cell	NNS
cord-015021-pol2qm74	3318	33	to	to	TO
cord-015021-pol2qm74	3318	34	produce	produce	VB
cord-015021-pol2qm74	3318	35	TNF	TNF	NNP
cord-015021-pol2qm74	3318	36	immediately	immediately	RB
cord-015021-pol2qm74	3318	37	after	after	IN
cord-015021-pol2qm74	3318	38	bleeding	bleed	VBG
cord-015021-pol2qm74	3318	39	.	.	.
cord-015021-pol2qm74	3319	1	In	in	IN
cord-015021-pol2qm74	3319	2	vivo	vivo	NN
cord-015021-pol2qm74	3319	3	studies	study	NNS
cord-015021-pol2qm74	3319	4	:	:	:
cord-015021-pol2qm74	3319	5	Baboons	baboon	NNS
cord-015021-pol2qm74	3319	6	were	be	VBD
cord-015021-pol2qm74	3319	7	subjected	subject	VBN
cord-015021-pol2qm74	3319	8	to	to	IN
cord-015021-pol2qm74	3319	9	a	a	DT
cord-015021-pol2qm74	3319	10	limited	limited	JJ
cord-015021-pol2qm74	3319	11	oxygen	oxygen	NN
cord-015021-pol2qm74	3319	12	deficit	deficit	NN
cord-015021-pol2qm74	3319	13	(	(	-LRB-
cord-015021-pol2qm74	3319	14	180	180	CD
cord-015021-pol2qm74	3319	15	-	-	SYM
cord-015021-pol2qm74	3319	16	200	200	CD
cord-015021-pol2qm74	3319	17	ml	ml	NNS
cord-015021-pol2qm74	3319	18	/	/	SYM
cord-015021-pol2qm74	3319	19	kg	kg	NN
cord-015021-pol2qm74	3319	20	)	)	-RRB-
cord-015021-pol2qm74	3320	1	hypotension	hypotension	NN
cord-015021-pol2qm74	3320	2	phase	phase	NN
cord-015021-pol2qm74	3320	3	(	(	-LRB-
cord-015021-pol2qm74	3320	4	mean	mean	VB
cord-015021-pol2qm74	3320	5	arterial	arterial	JJ
cord-015021-pol2qm74	3320	6	pressure	pressure	NN
cord-015021-pol2qm74	3320	7	=	=	:
cord-015021-pol2qm74	3320	8	MAP	map	NN
cord-015021-pol2qm74	3320	9	of	of	IN
cord-015021-pol2qm74	3320	10	35	35	CD
cord-015021-pol2qm74	3320	11	-	-	SYM
cord-015021-pol2qm74	3320	12	40	40	CD
cord-015021-pol2qm74	3320	13	mmHg	mmHg	NNS
cord-015021-pol2qm74	3320	14	for	for	IN
cord-015021-pol2qm74	3320	15	2	2	CD
cord-015021-pol2qm74	3320	16	-	-	SYM
cord-015021-pol2qm74	3320	17	4	4	CD
cord-015021-pol2qm74	3320	18	hours	hour	NNS
cord-015021-pol2qm74	3320	19	followed	follow	VBN
cord-015021-pol2qm74	3320	20	by	by	IN
cord-015021-pol2qm74	3320	21	adequate	adequate	JJ
cord-015021-pol2qm74	3320	22	resuscitation	resuscitation	NN
cord-015021-pol2qm74	3320	23	)	)	-RRB-
cord-015021-pol2qm74	3320	24	.	.	.
cord-015021-pol2qm74	3321	1	Rats	rat	NNS
cord-015021-pol2qm74	3321	2	subjected	subject	VBN
cord-015021-pol2qm74	3321	3	to	to	IN
cord-015021-pol2qm74	3321	4	HS	HS	NNP
cord-015021-pol2qm74	3321	5	(	(	-LRB-
cord-015021-pol2qm74	3321	6	MAP	MAP	NNP
cord-015021-pol2qm74	3321	7	of	of	IN
cord-015021-pol2qm74	3321	8	30	30	CD
cord-015021-pol2qm74	3321	9	-	-	SYM
cord-015021-pol2qm74	3321	10	35	35	CD
cord-015021-pol2qm74	3321	11	mmHg	mmHg	NNS
cord-015021-pol2qm74	3321	12	for	for	IN
cord-015021-pol2qm74	3321	13	90	90	CD
cord-015021-pol2qm74	3321	14	rain	rain	NN
cord-015021-pol2qm74	3321	15	followed	follow	VBN
cord-015021-pol2qm74	3321	16	by	by	IN
cord-015021-pol2qm74	3321	17	reinfusion	reinfusion	NN
cord-015021-pol2qm74	3321	18	of	of	IN
cord-015021-pol2qm74	3321	19	shed	shed	JJ
cord-015021-pol2qm74	3321	20	blood	blood	NN
cord-015021-pol2qm74	3321	21	and	and	CC
cord-015021-pol2qm74	3321	22	fluid	fluid	NN
cord-015021-pol2qm74	3321	23	resuscitation	resuscitation	NN
cord-015021-pol2qm74	3321	24	)	)	-RRB-
cord-015021-pol2qm74	3321	25	were	be	VBD
cord-015021-pol2qm74	3321	26	challenged	challenge	VBN
cord-015021-pol2qm74	3321	27	with	with	IN
cord-015021-pol2qm74	3321	28	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3321	29	(	(	-LRB-
cord-015021-pol2qm74	3321	30	1	1	CD
cord-015021-pol2qm74	3321	31	~g	~g	NN
cord-015021-pol2qm74	3322	1	/kg	/kg	NFP
cord-015021-pol2qm74	3322	2	i.v	i.v	NNP
cord-015021-pol2qm74	3322	3	.	.	.
cord-015021-pol2qm74	3322	4	)	)	-RRB-
cord-015021-pol2qm74	3323	1	at	at	IN
cord-015021-pol2qm74	3323	2	the	the	DT
cord-015021-pol2qm74	3323	3	end	end	NN
cord-015021-pol2qm74	3323	4	of	of	IN
cord-015021-pol2qm74	3323	5	shock	shock	NN
cord-015021-pol2qm74	3323	6	(	(	-LRB-
cord-015021-pol2qm74	3323	7	RHS	RHS	NNP
cord-015021-pol2qm74	3323	8	group	group	NN
cord-015021-pol2qm74	3323	9	)	)	-RRB-
cord-015021-pol2qm74	3323	10	.	.	.
cord-015021-pol2qm74	3324	1	The	the	DT
cord-015021-pol2qm74	3324	2	control	control	NN
cord-015021-pol2qm74	3324	3	group	group	NN
cord-015021-pol2qm74	3324	4	(	(	-LRB-
cord-015021-pol2qm74	3324	5	RCO	RCO	NNP
cord-015021-pol2qm74	3324	6	)	)	-RRB-
cord-015021-pol2qm74	3324	7	received	receive	VBD
cord-015021-pol2qm74	3324	8	the	the	DT
cord-015021-pol2qm74	3324	9	same	same	JJ
cord-015021-pol2qm74	3324	10	dose	dose	NN
cord-015021-pol2qm74	3324	11	of	of	IN
cord-015021-pol2qm74	3324	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3324	13	as	as	IN
cord-015021-pol2qm74	3324	14	RHS	RHS	NNP
cord-015021-pol2qm74	3324	15	group	group	NN
cord-015021-pol2qm74	3324	16	but	but	CC
cord-015021-pol2qm74	3324	17	without	without	IN
cord-015021-pol2qm74	3324	18	prior	prior	JJ
cord-015021-pol2qm74	3324	19	bleeding	bleed	VBG
cord-015021-pol2qm74	3324	20	.	.	.
cord-015021-pol2qm74	3325	1	In	in	IN
cord-015021-pol2qm74	3325	2	Vitro	Vitro	NNP
cord-015021-pol2qm74	3325	3	studies	study	NNS
cord-015021-pol2qm74	3325	4	:	:	:
cord-015021-pol2qm74	3325	5	Whole	whole	JJ
cord-015021-pol2qm74	3325	6	blood	blood	NN
cord-015021-pol2qm74	3325	7	(	(	-LRB-
cord-015021-pol2qm74	3325	8	WB	WB	NNP
cord-015021-pol2qm74	3325	9	)	)	-RRB-
cord-015021-pol2qm74	3325	10	obtained	obtain	VBD
cord-015021-pol2qm74	3325	11	from	from	IN
cord-015021-pol2qm74	3325	12	both	both	DT
cord-015021-pol2qm74	3325	13	baboons	baboon	NNS
cord-015021-pol2qm74	3325	14	and	and	CC
cord-015021-pol2qm74	3325	15	rats	rat	NNS
cord-015021-pol2qm74	3325	16	before	before	IN
cord-015021-pol2qm74	3325	17	and	and	CC
cord-015021-pol2qm74	3325	18	at	at	IN
cord-015021-pol2qm74	3325	19	the	the	DT
cord-015021-pol2qm74	3325	20	end	end	NN
cord-015021-pol2qm74	3325	21	of	of	IN
cord-015021-pol2qm74	3325	22	HS	HS	NNP
cord-015021-pol2qm74	3325	23	were	be	VBD
cord-015021-pol2qm74	3325	24	incubated	incubate	VBN
cord-015021-pol2qm74	3325	25	with	with	IN
cord-015021-pol2qm74	3325	26	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3325	27	(	(	-LRB-
cord-015021-pol2qm74	3325	28	100	100	CD
cord-015021-pol2qm74	3325	29	ng	ng	NN
cord-015021-pol2qm74	3325	30	/	/	SYM
cord-015021-pol2qm74	3325	31	ml	ml	NN
cord-015021-pol2qm74	3325	32	)	)	-RRB-
cord-015021-pol2qm74	3325	33	for	for	IN
cord-015021-pol2qm74	3325	34	2	2	CD
cord-015021-pol2qm74	3325	35	hrs	hrs	NN
cord-015021-pol2qm74	3325	36	at	at	IN
cord-015021-pol2qm74	3325	37	37	37	CD
cord-015021-pol2qm74	3325	38	°	°	NN
cord-015021-pol2qm74	3325	39	C	c	NN
cord-015021-pol2qm74	3325	40	.	.	.
cord-015021-pol2qm74	3326	1	Results	result	NNS
cord-015021-pol2qm74	3326	2	:	:	:
cord-015021-pol2qm74	3327	1	At	at	IN
cord-015021-pol2qm74	3327	2	90	90	CD
cord-015021-pol2qm74	3327	3	min	min	NN
cord-015021-pol2qm74	3327	4	post	post	JJ
cord-015021-pol2qm74	3327	5	-	-	JJ
cord-015021-pol2qm74	3327	6	LPS	lps	JJ
cord-015021-pol2qm74	3327	7	challenge	challenge	NN
cord-015021-pol2qm74	3327	8	we	-PRON-	PRP
cord-015021-pol2qm74	3327	9	found	find	VBD
cord-015021-pol2qm74	3327	10	significantly	significantly	RB
cord-015021-pol2qm74	3327	11	higher	high	JJR
cord-015021-pol2qm74	3327	12	plasma	plasma	NN
cord-015021-pol2qm74	3327	13	TNF	TNF	NNP
cord-015021-pol2qm74	3327	14	levels	level	NNS
cord-015021-pol2qm74	3327	15	in	in	IN
cord-015021-pol2qm74	3327	16	rats	rat	NNS
cord-015021-pol2qm74	3327	17	that	that	WDT
cord-015021-pol2qm74	3327	18	were	be	VBD
cord-015021-pol2qm74	3327	19	subjected	subject	VBN
cord-015021-pol2qm74	3327	20	to	to	IN
cord-015021-pol2qm74	3327	21	HS	HS	NNP
cord-015021-pol2qm74	3327	22	prior	prior	RB
cord-015021-pol2qm74	3327	23	to	to	IN
cord-015021-pol2qm74	3327	24	the	the	DT
cord-015021-pol2qm74	3327	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3327	26	challenge	challenge	NN
cord-015021-pol2qm74	3327	27	as	as	IN
cord-015021-pol2qm74	3327	28	compared	compare	VBN
cord-015021-pol2qm74	3327	29	to	to	IN
cord-015021-pol2qm74	3327	30	the	the	DT
cord-015021-pol2qm74	3327	31	control	control	NN
cord-015021-pol2qm74	3327	32	group	group	NN
cord-015021-pol2qm74	3327	33	(	(	-LRB-
cord-015021-pol2qm74	3328	1	956	956	CD
cord-015021-pol2qm74	3328	2	_	_	NN
cord-015021-pol2qm74	3328	3	+	+	SYM
cord-015021-pol2qm74	3328	4	585	585	CD
cord-015021-pol2qm74	3328	5	vs	vs	IN
cord-015021-pol2qm74	3328	6	276	276	CD
cord-015021-pol2qm74	3328	7	+	+	SYM
cord-015021-pol2qm74	3328	8	199	199	CD
cord-015021-pol2qm74	3328	9	pg	pg	NN
cord-015021-pol2qm74	3328	10	/	/	SYM
cord-015021-pol2qm74	3328	11	ml	ml	NN
cord-015021-pol2qm74	3328	12	)	)	-RRB-
cord-015021-pol2qm74	3328	13	.	.	.
cord-015021-pol2qm74	3329	1	After	after	IN
cord-015021-pol2qm74	3329	2	HS	HS	NNP
cord-015021-pol2qm74	3330	1	the	the	DT
cord-015021-pol2qm74	3330	2	TPC	TPC	NNP
cord-015021-pol2qm74	3330	3	was	be	VBD
cord-015021-pol2qm74	3330	4	significantly	significantly	RB
cord-015021-pol2qm74	3330	5	decreased	decrease	VBN
cord-015021-pol2qm74	3330	6	in	in	RP
cord-015021-pol2qm74	3330	7	in	in	IN
cord-015021-pol2qm74	3330	8	vitro	vitro	FW
cord-015021-pol2qm74	3330	9	stimulated	stimulate	VBD
cord-015021-pol2qm74	3330	10	CBC	CBC	NNP
cord-015021-pol2qm74	3330	11	of	of	IN
cord-015021-pol2qm74	3330	12	both	both	DT
cord-015021-pol2qm74	3330	13	rats	rat	NNS
cord-015021-pol2qm74	3330	14	(	(	-LRB-
cord-015021-pol2qm74	3330	15	12	12	CD
cord-015021-pol2qm74	3330	16	+	+	SYM
cord-015021-pol2qm74	3330	17	4	4	CD
cord-015021-pol2qm74	3330	18	post	post	JJ
cord-015021-pol2qm74	3330	19	-	-	JJ
cord-015021-pol2qm74	3330	20	HS	hs	NN
cord-015021-pol2qm74	3330	21	vs	vs	IN
cord-015021-pol2qm74	3331	1	164	164	CD
cord-015021-pol2qm74	3331	2	+	+	SYM
cord-015021-pol2qm74	3331	3	89	89	CD
cord-015021-pol2qm74	3331	4	ng	ng	NNP
cord-015021-pol2qm74	3331	5	TNF	TNF	NNP
cord-015021-pol2qm74	3331	6	/	/	SYM
cord-015021-pol2qm74	3331	7	ml	ml	XX
cord-015021-pol2qm74	3331	8	pre	pre	JJ
cord-015021-pol2qm74	3331	9	-	-	JJ
cord-015021-pol2qm74	3331	10	HS	HS	NNP
cord-015021-pol2qm74	3331	11	)	)	-RRB-
cord-015021-pol2qm74	3331	12	and	and	CC
cord-015021-pol2qm74	3331	13	baboons	baboon	NNS
cord-015021-pol2qm74	3331	14	(	(	-LRB-
cord-015021-pol2qm74	3331	15	8	8	CD
cord-015021-pol2qm74	3331	16	±	±	NNP
cord-015021-pol2qm74	3331	17	16	16	CD
cord-015021-pol2qm74	3331	18	post	post	JJ
cord-015021-pol2qm74	3331	19	-	-	JJ
cord-015021-pol2qm74	3331	20	HS	hs	NN
cord-015021-pol2qm74	3331	21	vs	vs	IN
cord-015021-pol2qm74	3331	22	233	233	CD
cord-015021-pol2qm74	3331	23	±	±	CD
cord-015021-pol2qm74	3331	24	188	188	CD
cord-015021-pol2qm74	3332	1	pg	pg	NNP
cord-015021-pol2qm74	3332	2	TNF	TNF	NNP
cord-015021-pol2qm74	3332	3	/	/	SYM
cord-015021-pol2qm74	3332	4	ml	ml	XX
cord-015021-pol2qm74	3332	5	pre	pre	JJ
cord-015021-pol2qm74	3332	6	-	-	JJ
cord-015021-pol2qm74	3332	7	HS	HS	NNP
cord-015021-pol2qm74	3332	8	)	)	-RRB-
cord-015021-pol2qm74	3332	9	.	.	.
cord-015021-pol2qm74	3333	1	In	in	IN
cord-015021-pol2qm74	3333	2	contrast	contrast	NN
cord-015021-pol2qm74	3333	3	,	,	,
cord-015021-pol2qm74	3333	4	the	the	DT
cord-015021-pol2qm74	3333	5	IL-6	IL-6	NNP
cord-015021-pol2qm74	3333	6	productive	productive	JJ
cord-015021-pol2qm74	3333	7	capacity	capacity	NN
cord-015021-pol2qm74	3333	8	was	be	VBD
cord-015021-pol2qm74	3333	9	increased	increase	VBN
cord-015021-pol2qm74	3333	10	in	in	IN
cord-015021-pol2qm74	3333	11	baboons	baboon	NNS
cord-015021-pol2qm74	3333	12	CBC	CBC	NNP
cord-015021-pol2qm74	3333	13	(	(	-LRB-
cord-015021-pol2qm74	3333	14	not	not	RB
cord-015021-pol2qm74	3333	15	yet	yet	RB
cord-015021-pol2qm74	3333	16	analysed	analyse	VBN
cord-015021-pol2qm74	3333	17	in	in	IN
cord-015021-pol2qm74	3333	18	rats	rat	NNS
cord-015021-pol2qm74	3333	19	)	)	-RRB-
cord-015021-pol2qm74	3333	20	stimulated	stimulate	VBD
cord-015021-pol2qm74	3333	21	at	at	IN
cord-015021-pol2qm74	3333	22	the	the	DT
cord-015021-pol2qm74	3333	23	end	end	NN
cord-015021-pol2qm74	3333	24	of	of	IN
cord-015021-pol2qm74	3333	25	HS	HS	NNP
cord-015021-pol2qm74	3333	26	(	(	-LRB-
cord-015021-pol2qm74	3333	27	224	224	CD
cord-015021-pol2qm74	3333	28	±	±	CD
cord-015021-pol2qm74	3333	29	106	106	CD
cord-015021-pol2qm74	3333	30	pre	pre	NN
cord-015021-pol2qm74	3333	31	-	-	JJ
cord-015021-pol2qm74	3333	32	vs	vs	JJ
cord-015021-pol2qm74	3333	33	1545	1545	CD
cord-015021-pol2qm74	3334	1	±	±	NNP
cord-015021-pol2qm74	3334	2	_	_	NN
cord-015021-pol2qm74	3334	3	1254	1254	CD
cord-015021-pol2qm74	3334	4	pg	pg	NNP
cord-015021-pol2qm74	3334	5	IL-6	IL-6	NNP
cord-015021-pol2qm74	3334	6	/	/	,
cord-015021-pol2qm74	3334	7	ml	ml	CC
cord-015021-pol2qm74	3334	8	post	post	JJ
cord-015021-pol2qm74	3334	9	-	-	JJ
cord-015021-pol2qm74	3334	10	HS	HS	NNP
cord-015021-pol2qm74	3334	11	)	)	-RRB-
cord-015021-pol2qm74	3334	12	.	.	.
cord-015021-pol2qm74	3335	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	3335	2	:	:	:
cord-015021-pol2qm74	3336	1	From	from	IN
cord-015021-pol2qm74	3336	2	our	-PRON-	PRP$
cord-015021-pol2qm74	3336	3	data	datum	NNS
cord-015021-pol2qm74	3336	4	we	-PRON-	PRP
cord-015021-pol2qm74	3336	5	suggest	suggest	VBP
cord-015021-pol2qm74	3336	6	that	that	IN
cord-015021-pol2qm74	3336	7	despite	despite	IN
cord-015021-pol2qm74	3336	8	of	of	IN
cord-015021-pol2qm74	3336	9	down	down	JJ
cord-015021-pol2qm74	3336	10	regulation	regulation	NN
cord-015021-pol2qm74	3336	11	of	of	IN
cord-015021-pol2qm74	3336	12	the	the	DT
cord-015021-pol2qm74	3336	13	CBC	CBC	NNP
cord-015021-pol2qm74	3336	14	to	to	TO
cord-015021-pol2qm74	3336	15	produce	produce	VB
cord-015021-pol2qm74	3336	16	TNF	TNF	NNP
cord-015021-pol2qm74	3337	1	the	the	DT
cord-015021-pol2qm74	3337	2	overall	overall	JJ
cord-015021-pol2qm74	3337	3	TPC	TPC	NNP
cord-015021-pol2qm74	3337	4	is	be	VBZ
cord-015021-pol2qm74	3337	5	enhanced	enhance	VBN
cord-015021-pol2qm74	3337	6	at	at	IN
cord-015021-pol2qm74	3337	7	the	the	DT
cord-015021-pol2qm74	3337	8	early	early	JJ
cord-015021-pol2qm74	3337	9	stage	stage	NN
cord-015021-pol2qm74	3337	10	of	of	IN
cord-015021-pol2qm74	3337	11	I	i	NN
cord-015021-pol2qm74	3337	12	-	-	HYPH
cord-015021-pol2qm74	3337	13	IS	be	VBZ
cord-015021-pol2qm74	3337	14	.	.	.
cord-015021-pol2qm74	3338	1	With	with	IN
cord-015021-pol2qm74	3338	2	regard	regard	NN
cord-015021-pol2qm74	3338	3	to	to	IN
cord-015021-pol2qm74	3338	4	the	the	DT
cord-015021-pol2qm74	3338	5	related	related	JJ
cord-015021-pol2qm74	3338	6	literature	literature	NN
cord-015021-pol2qm74	3338	7	(	(	-LRB-
cord-015021-pol2qm74	3338	8	Chaudry	Chaudry	NNP
cord-015021-pol2qm74	3338	9	's	's	POS
cord-015021-pol2qm74	3338	10	group	group	NN
cord-015021-pol2qm74	3338	11	)	)	-RRB-
cord-015021-pol2qm74	3338	12	it	-PRON-	PRP
cord-015021-pol2qm74	3338	13	can	can	MD
cord-015021-pol2qm74	3338	14	be	be	VB
cord-015021-pol2qm74	3338	15	assumed	assume	VBN
cord-015021-pol2qm74	3338	16	that	that	IN
cord-015021-pol2qm74	3338	17	among	among	IN
cord-015021-pol2qm74	3338	18	the	the	DT
cord-015021-pol2qm74	3338	19	macrophage	macrophage	NN
cord-015021-pol2qm74	3338	20	/	/	SYM
cord-015021-pol2qm74	3338	21	monocyte	monocyte	JJ
cord-015021-pol2qm74	3338	22	populations	population	NNS
cord-015021-pol2qm74	3338	23	,	,	,
cord-015021-pol2qm74	3338	24	as	as	IN
cord-015021-pol2qm74	3338	25	the	the	DT
cord-015021-pol2qm74	3338	26	main	main	JJ
cord-015021-pol2qm74	3338	27	source	source	NN
cord-015021-pol2qm74	3338	28	only	only	RB
cord-015021-pol2qm74	3338	29	the	the	DT
cord-015021-pol2qm74	3338	30	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	3338	31	cells	cell	NNS
cord-015021-pol2qm74	3338	32	(	(	-LRB-
cord-015021-pol2qm74	3338	33	KC	KC	NNP
cord-015021-pol2qm74	3338	34	)	)	-RRB-
cord-015021-pol2qm74	3338	35	exhibit	exhibit	NN
cord-015021-pol2qm74	3338	36	enhanced	enhance	VBN
cord-015021-pol2qm74	3338	37	TNF	TNF	NNP
cord-015021-pol2qm74	3338	38	production	production	NN
cord-015021-pol2qm74	3338	39	capacity	capacity	NN
cord-015021-pol2qm74	3338	40	following	follow	VBG
cord-015021-pol2qm74	3338	41	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	3338	42	.	.	.
cord-015021-pol2qm74	3339	1	The	the	DT
cord-015021-pol2qm74	3339	2	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3339	3	of	of	IN
cord-015021-pol2qm74	3339	4	down	down	RB
cord-015021-pol2qm74	3339	5	/	/	SYM
cord-015021-pol2qm74	3339	6	up	up	JJ
cord-015021-pol2qm74	3339	7	regulation	regulation	NN
cord-015021-pol2qm74	3339	8	of	of	IN
cord-015021-pol2qm74	3339	9	cytokine	cytokine	NN
cord-015021-pol2qm74	3339	10	response	response	NN
cord-015021-pol2qm74	3339	11	of	of	IN
cord-015021-pol2qm74	3339	12	CBC	CBC	NNP
cord-015021-pol2qm74	3339	13	and/or	and/or	CC
cord-015021-pol2qm74	3339	14	KC	KC	NNP
cord-015021-pol2qm74	3339	15	following	follow	VBG
cord-015021-pol2qm74	3339	16	HS	HS	NNP
cord-015021-pol2qm74	3339	17	remain	remain	VBP
cord-015021-pol2qm74	3339	18	to	to	TO
cord-015021-pol2qm74	3339	19	be	be	VB
cord-015021-pol2qm74	3339	20	examined	examine	VBN
cord-015021-pol2qm74	3339	21	.	.	.
cord-015021-pol2qm74	3340	1	D.	D.	NNP
cord-015021-pol2qm74	3341	1	Eg	Eg	NNP
cord-015021-pol2qm74	3341	2	~	~	NFP
cord-015021-pol2qm74	3341	3	er	er	UH
cord-015021-pol2qm74	3341	4	,	,	,
cord-015021-pol2qm74	3341	5	S.	S.	NNP
cord-015021-pol2qm74	3341	6	Geuenich	Geuenich	NNP
cord-015021-pol2qm74	3341	7	°	°	NNS
cord-015021-pol2qm74	3341	8	,	,	,
cord-015021-pol2qm74	3341	9	C.	C.	NNP
cord-015021-pol2qm74	3341	10	Dertzlin	Dertzlin	NNP
cord-015021-pol2qm74	3341	11	~	~	NFP
cord-015021-pol2qm74	3341	12	er	er	UH
cord-015021-pol2qm74	3341	13	°	°	NN
cord-015021-pol2qm74	3341	14	,	,	,
cord-015021-pol2qm74	3341	15	E.	E.	NNP
cord-015021-pol2qm74	3341	16	Schmitt	Schmitt	NNP
cord-015021-pol2qm74	3341	17	*	*	NFP
cord-015021-pol2qm74	3341	18	,	,	,
cord-015021-pol2qm74	3341	19	R.	R.	NNP
cord-015021-pol2qm74	3341	20	Mailhammer	Mailhammer	NNP
cord-015021-pol2qm74	3341	21	,	,	,
cord-015021-pol2qm74	3341	22	H	H	NNP
cord-015021-pol2qm74	3341	23	Ehrenreich	Ehrenreich	NNP
cord-015021-pol2qm74	3341	24	#	#	NN
cord-015021-pol2qm74	3341	25	,	,	,
cord-015021-pol2qm74	3341	26	P.	P.	NNP
cord-015021-pol2qm74	3341	27	Drrmer	Drrmer	NNP
cord-015021-pol2qm74	3341	28	,	,	,
cord-015021-pol2qm74	3341	29	and	and	CC
cord-015021-pol2qm74	3341	30	L.	L.	NNP
cord-015021-pol2qm74	3341	31	H01mer	H01mer	NNP
cord-015021-pol2qm74	3341	32	GSF	GSF	NNP
cord-015021-pol2qm74	3341	33	-	-	HYPH
cord-015021-pol2qm74	3341	34	Instimt	Instimt	NNP
cord-015021-pol2qm74	3341	35	fox	fox	NN
cord-015021-pol2qm74	3341	36	Experimentelle	Experimentelle	NNP
cord-015021-pol2qm74	3341	37	H	H	NNP
cord-015021-pol2qm74	3341	38	~	~	NFP
cord-015021-pol2qm74	3341	39	znatologie	znatologie	NN
cord-015021-pol2qm74	3341	40	,	,	,
cord-015021-pol2qm74	3341	41	°	°	NNP
cord-015021-pol2qm74	3341	42	Medizinische	Medizinische	NNP
cord-015021-pol2qm74	3341	43	Kliulk	Kliulk	NNP
cord-015021-pol2qm74	3341	44	III	III	NNP
cord-015021-pol2qm74	3341	45	,	,	,
cord-015021-pol2qm74	3341	46	Klinikum	Klinikum	NNP
cord-015021-pol2qm74	3341	47	Groghadern	Groghadern	NNP
cord-015021-pol2qm74	3341	48	,	,	,
cord-015021-pol2qm74	3341	49	Munich	Munich	NNP
cord-015021-pol2qm74	3341	50	,	,	,
cord-015021-pol2qm74	3342	1	*	*	NFP
cord-015021-pol2qm74	3342	2	Institut	Institut	NNP
cord-015021-pol2qm74	3342	3	for	for	IN
cord-015021-pol2qm74	3342	4	Immunologic	Immunologic	NNP
cord-015021-pol2qm74	3342	5	,	,	,
cord-015021-pol2qm74	3342	6	Johannes	Johannes	NNP
cord-015021-pol2qm74	3342	7	Gutenberg	Gutenberg	NNP
cord-015021-pol2qm74	3342	8	Universit	Universit	NNP
cord-015021-pol2qm74	3343	1	/	/	NFP
cord-015021-pol2qm74	3344	1	it	-PRON-	PRP
cord-015021-pol2qm74	3344	2	,	,	,
cord-015021-pol2qm74	3344	3	Malnz	Malnz	NNP
cord-015021-pol2qm74	3344	4	,	,	,
cord-015021-pol2qm74	3344	5	and	and	CC
cord-015021-pol2qm74	3344	6	#	#	$
cord-015021-pol2qm74	3344	7	Psychiatrische	Psychiatrische	NNP
cord-015021-pol2qm74	3344	8	K/	K/	NNP
cord-015021-pol2qm74	3345	1	in	in	IN
cord-015021-pol2qm74	3345	2	&	&	CC
cord-015021-pol2qm74	3345	3	der	der	NNP
cord-015021-pol2qm74	3345	4	Georg	Georg	NNP
cord-015021-pol2qm74	3345	5	-	-	HYPH
cord-015021-pol2qm74	3345	6	Aagust	Aagust	NNP
cord-015021-pol2qm74	3345	7	-	-	HYPH
cord-015021-pol2qm74	3345	8	Universi	Universi	NNP
cord-015021-pol2qm74	3346	1	~t	~t	NNP
cord-015021-pol2qm74	3346	2	,	,	,
cord-015021-pol2qm74	3346	3	Grttingen	Grttingen	NNP
cord-015021-pol2qm74	3346	4	,	,	,
cord-015021-pol2qm74	3346	5	Germany	Germany	NNP
cord-015021-pol2qm74	3346	6	.	.	.
cord-015021-pol2qm74	3347	1	It	-PRON-	PRP
cord-015021-pol2qm74	3347	2	has	have	VBZ
cord-015021-pol2qm74	3347	3	been	be	VBN
cord-015021-pol2qm74	3347	4	shown	show	VBN
cord-015021-pol2qm74	3347	5	previously	previously	RB
cord-015021-pol2qm74	3348	1	(	(	-LRB-
cord-015021-pol2qm74	3348	2	Ehranreich	Ehranreich	NNP
cord-015021-pol2qm74	3348	3	et	et	NNP
cord-015021-pol2qm74	3348	4	al	al	NNP
cord-015021-pol2qm74	3348	5	.	.	NNP
cord-015021-pol2qm74	3348	6	,	,	,
cord-015021-pol2qm74	3348	7	1992	1992	CD
cord-015021-pol2qm74	3348	8	,	,	,
cord-015021-pol2qm74	3348	9	New	New	NNP
cord-015021-pol2qm74	3348	10	Biol	Biol	NNP
cord-015021-pol2qm74	3348	11	.	.	NNP
cord-015021-pol2qm74	3348	12	4	4	CD
cord-015021-pol2qm74	3348	13	:	:	SYM
cord-015021-pol2qm74	3348	14	147	147	CD
cord-015021-pol2qm74	3348	15	)	)	-RRB-
cord-015021-pol2qm74	3348	16	that	that	IN
cord-015021-pol2qm74	3348	17	mouse	mouse	NN
cord-015021-pol2qm74	3348	18	bone	bone	NN
cord-015021-pol2qm74	3348	19	marrow	marrow	NN
cord-015021-pol2qm74	3348	20	-	-	HYPH
cord-015021-pol2qm74	3348	21	derived	derive	VBN
cord-015021-pol2qm74	3348	22	mast	mast	NN
cord-015021-pol2qm74	3348	23	cells	cell	NNS
cord-015021-pol2qm74	3348	24	(	(	-LRB-
cord-015021-pol2qm74	3348	25	BMMC	BMMC	NNP
cord-015021-pol2qm74	3348	26	)	)	-RRB-
cord-015021-pol2qm74	3348	27	synthesize	synthesize	VB
cord-015021-pol2qm74	3348	28	and	and	CC
cord-015021-pol2qm74	3349	1	secrete	secrete	VB
cord-015021-pol2qm74	3349	2	endothelin-1	endothelin-1	XX
cord-015021-pol2qm74	3350	1	(	(	-LRB-
cord-015021-pol2qm74	3350	2	ET	et	NN
cord-015021-pol2qm74	3350	3	-	-	HYPH
cord-015021-pol2qm74	3350	4	I	I	NNP
cord-015021-pol2qm74	3350	5	)	)	-RRB-
cord-015021-pol2qm74	3350	6	and	and	CC
cord-015021-pol2qm74	3350	7	express	express	VB
cord-015021-pol2qm74	3350	8	ETA	ETA	NNP
cord-015021-pol2qm74	3350	9	-	-	HYPH
cord-015021-pol2qm74	3350	10	type	type	NN
cord-015021-pol2qm74	3350	11	endothelin	endothelin	NN
cord-015021-pol2qm74	3350	12	receptors	receptor	NNS
cord-015021-pol2qm74	3350	13	(	(	-LRB-
cord-015021-pol2qm74	3350	14	ETA	ETA	NNP
cord-015021-pol2qm74	3350	15	)	)	-RRB-
cord-015021-pol2qm74	3350	16	.	.	.
cord-015021-pol2qm74	3351	1	So	so	RB
cord-015021-pol2qm74	3351	2	far	far	RB
cord-015021-pol2qm74	3351	3	,	,	,
cord-015021-pol2qm74	3351	4	however	however	RB
cord-015021-pol2qm74	3351	5	,	,	,
cord-015021-pol2qm74	3351	6	no	no	DT
cord-015021-pol2qm74	3351	7	functions	function	NNS
cord-015021-pol2qm74	3351	8	of	of	IN
cord-015021-pol2qm74	3351	9	ET-1	ET-1	NNP
cord-015021-pol2qm74	3351	10	/	/	SYM
cord-015021-pol2qm74	3351	11	ET	ET	NNP
cord-015021-pol2qm74	3351	12	A	A	NNP
cord-015021-pol2qm74	3351	13	in	in	IN
cord-015021-pol2qm74	3351	14	BMMC	BMMC	NNP
cord-015021-pol2qm74	3351	15	have	have	VBP
cord-015021-pol2qm74	3351	16	been	be	VBN
cord-015021-pol2qm74	3351	17	described	describe	VBN
cord-015021-pol2qm74	3351	18	.	.	.
cord-015021-pol2qm74	3352	1	In	in	IN
cord-015021-pol2qm74	3352	2	the	the	DT
cord-015021-pol2qm74	3352	3	present	present	JJ
cord-015021-pol2qm74	3352	4	study	study	NN
cord-015021-pol2qm74	3352	5	we	-PRON-	PRP
cord-015021-pol2qm74	3352	6	investigated	investigate	VBD
cord-015021-pol2qm74	3352	7	the	the	DT
cord-015021-pol2qm74	3352	8	effect	effect	NN
cord-015021-pol2qm74	3352	9	of	of	IN
cord-015021-pol2qm74	3353	1	exogeneously	exogeneously	NNP
cord-015021-pol2qm74	3353	2	administered	administer	VBD
cord-015021-pol2qm74	3353	3	ET-1	ET-1	NNP
cord-015021-pol2qm74	3353	4	on	on	IN
cord-015021-pol2qm74	3353	5	the	the	DT
cord-015021-pol2qm74	3353	6	release	release	NN
cord-015021-pol2qm74	3353	7	of	of	IN
cord-015021-pol2qm74	3353	8	histamine	histamine	NN
cord-015021-pol2qm74	3353	9	,	,	,
cord-015021-pol2qm74	3353	10	serotonin	serotonin	NN
cord-015021-pol2qm74	3353	11	,	,	,
cord-015021-pol2qm74	3353	12	and	and	CC
cord-015021-pol2qm74	3353	13	leukotriene	leukotriene	NN
cord-015021-pol2qm74	3353	14	C	C	NNP
cord-015021-pol2qm74	3353	15	4	4	CD
cord-015021-pol2qm74	3353	16	(	(	-LRB-
cord-015021-pol2qm74	3353	17	LTC4	LTC4	NNP
cord-015021-pol2qm74	3353	18	)	)	-RRB-
cord-015021-pol2qm74	3353	19	by	by	IN
cord-015021-pol2qm74	3353	20	primary	primary	JJ
cord-015021-pol2qm74	3353	21	mouse	mouse	NN
cord-015021-pol2qm74	3353	22	BMMC	BMMC	NNP
cord-015021-pol2qm74	3353	23	(	(	-LRB-
cord-015021-pol2qm74	3353	24	in	in	FW
cord-015021-pol2qm74	3353	25	vitro	vitro	FW
cord-015021-pol2qm74	3353	26	age	age	NN
cord-015021-pol2qm74	3353	27	:	:	:
cord-015021-pol2qm74	3353	28	4	4	CD
cord-015021-pol2qm74	3353	29	weeks	week	NNS
cord-015021-pol2qm74	3353	30	)	)	-RRB-
cord-015021-pol2qm74	3353	31	caltured	calture	VBD
cord-015021-pol2qm74	3353	32	with	with	IN
cord-015021-pol2qm74	3353	33	different	different	JJ
cord-015021-pol2qm74	3353	34	recombinant	recombinant	JJ
cord-015021-pol2qm74	3353	35	mttrine	mttrine	NN
cord-015021-pol2qm74	3353	36	cytokines	cytokine	NNS
cord-015021-pol2qm74	3353	37	(	(	-LRB-
cord-015021-pol2qm74	3353	38	interleukin	interleukin	NN
cord-015021-pol2qm74	3353	39	3	3	CD
cord-015021-pol2qm74	3353	40	(	(	-LRB-
cord-015021-pol2qm74	3353	41	IL-3	IL-3	NNP
cord-015021-pol2qm74	3353	42	)	)	-RRB-
cord-015021-pol2qm74	3353	43	and/or	and/or	CC
cord-015021-pol2qm74	3353	44	kit	kit	NN
cord-015021-pol2qm74	3353	45	ligand	ligand	NN
cord-015021-pol2qm74	3353	46	(	(	-LRB-
cord-015021-pol2qm74	3353	47	KL	KL	NNP
cord-015021-pol2qm74	3353	48	)	)	-RRB-
cord-015021-pol2qm74	3353	49	in	in	IN
cord-015021-pol2qm74	3353	50	the	the	DT
cord-015021-pol2qm74	3353	51	presence	presence	NN
cord-015021-pol2qm74	3353	52	or	or	CC
cord-015021-pol2qm74	3353	53	absence	absence	NN
cord-015021-pol2qm74	3353	54	of	of	IN
cord-015021-pol2qm74	3353	55	IL4	il4	NN
cord-015021-pol2qm74	3353	56	)	)	-RRB-
cord-015021-pol2qm74	3353	57	for	for	IN
cord-015021-pol2qm74	3353	58	two	two	CD
cord-015021-pol2qm74	3353	59	weeks	week	NNS
cord-015021-pol2qm74	3353	60	prior	prior	RB
cord-015021-pol2qm74	3353	61	to	to	IN
cord-015021-pol2qm74	3353	62	activation	activation	NN
cord-015021-pol2qm74	3353	63	.	.	.
cord-015021-pol2qm74	3354	1	ET-1	ET-1	NNP
cord-015021-pol2qm74	3354	2	(	(	-LRB-
cord-015021-pol2qm74	3354	3	5x10	5x10	CD
cord-015021-pol2qm74	3354	4	-8	-8	VBG
cord-015021-pol2qm74	3354	5	to	to	IN
cord-015021-pol2qm74	3354	6	lxl0	lxl0	NN
cord-015021-pol2qm74	3354	7	-6	-6	NNP
cord-015021-pol2qm74	3354	8	M	M	NNP
cord-015021-pol2qm74	3355	1	)	)	-RRB-
cord-015021-pol2qm74	3355	2	induCed	induced	WDT
cord-015021-pol2qm74	3355	3	an	an	DT
cord-015021-pol2qm74	3355	4	extremely	extremely	RB
cord-015021-pol2qm74	3355	5	rapid	rapid	JJ
cord-015021-pol2qm74	3355	6	(	(	-LRB-
cord-015021-pol2qm74	3355	7	_	_	NN
cord-015021-pol2qm74	3355	8	<	<	XX
cord-015021-pol2qm74	3355	9	lmin	lmin	NNP
cord-015021-pol2qm74	3355	10	)	)	-RRB-
cord-015021-pol2qm74	3355	11	and	and	CC
cord-015021-pol2qm74	3355	12	dose	dose	NN
cord-015021-pol2qm74	3355	13	-	-	HYPH
cord-015021-pol2qm74	3355	14	dependent	dependent	JJ
cord-015021-pol2qm74	3355	15	release	release	NN
cord-015021-pol2qm74	3355	16	of	of	IN
cord-015021-pol2qm74	3355	17	histamine	histamine	NN
cord-015021-pol2qm74	3355	18	and	and	CC
cord-015021-pol2qm74	3355	19	serotonin	serotonin	NN
cord-015021-pol2qm74	3355	20	(	(	-LRB-
cord-015021-pol2qm74	3355	21	up	up	IN
cord-015021-pol2qm74	3355	22	to	to	TO
cord-015021-pol2qm74	3355	23	20	20	CD
cord-015021-pol2qm74	3355	24	%	%	NN
cord-015021-pol2qm74	3355	25	and	and	CC
cord-015021-pol2qm74	3355	26	16	16	CD
cord-015021-pol2qm74	3355	27	%	%	NN
cord-015021-pol2qm74	3355	28	of	of	IN
cord-015021-pol2qm74	3355	29	total	total	JJ
cord-015021-pol2qm74	3355	30	mediator	mediator	NN
cord-015021-pol2qm74	3355	31	content	content	NN
cord-015021-pol2qm74	3355	32	,	,	,
cord-015021-pol2qm74	3355	33	respectively	respectively	RB
cord-015021-pol2qm74	3355	34	,	,	,
cord-015021-pol2qm74	3355	35	comparable	comparable	JJ
cord-015021-pol2qm74	3355	36	to	to	IN
cord-015021-pol2qm74	3355	37	IgE	IgE	NNP
cord-015021-pol2qm74	3355	38	/	/	SYM
cord-015021-pol2qm74	3355	39	Ag	Ag	NNP
cord-015021-pol2qm74	3355	40	-	-	HYPH
cord-015021-pol2qm74	3355	41	indueed	indueed	NNP
cord-015021-pol2qm74	3355	42	mediator	mediator	NN
cord-015021-pol2qm74	3355	43	release	release	NN
cord-015021-pol2qm74	3355	44	)	)	-RRB-
cord-015021-pol2qm74	3355	45	from	from	IN
cord-015021-pol2qm74	3355	46	BMMC	BMMC	NNP
cord-015021-pol2qm74	3355	47	cultured	culture	VBN
cord-015021-pol2qm74	3355	48	with	with	IN
cord-015021-pol2qm74	3355	49	IL-3	IL-3	NNP
cord-015021-pol2qm74	3355	50	and	and	CC
cord-015021-pol2qm74	3355	51	IL-4	IL-4	NNP
cord-015021-pol2qm74	3355	52	.	.	.
cord-015021-pol2qm74	3356	1	Only	only	RB
cord-015021-pol2qm74	3356	2	when	when	WRB
cord-015021-pol2qm74	3356	3	cultured	culture	VBN
cord-015021-pol2qm74	3356	4	in	in	IN
cord-015021-pol2qm74	3356	5	the	the	DT
cord-015021-pol2qm74	3356	6	additional	additional	JJ
cord-015021-pol2qm74	3356	7	presence	presence	NN
cord-015021-pol2qm74	3356	8	of	of	IN
cord-015021-pol2qm74	3356	9	IL-4	IL-4	NNP
cord-015021-pol2qm74	3356	10	rather	rather	RB
cord-015021-pol2qm74	3356	11	than	than	IN
cord-015021-pol2qm74	3356	12	in	in	IN
cord-015021-pol2qm74	3356	13	medium	medium	NN
cord-015021-pol2qm74	3356	14	containing	contain	VBG
cord-015021-pol2qm74	3356	15	KL	KL	NNP
cord-015021-pol2qm74	3356	16	or	or	CC
cord-015021-pol2qm74	3356	17	KL	KL	NNP
cord-015021-pol2qm74	3356	18	plus	plus	CC
cord-015021-pol2qm74	3356	19	IL-3	IL-3	NNP
cord-015021-pol2qm74	3357	1	alone	alone	RB
cord-015021-pol2qm74	3357	2	,	,	,
cord-015021-pol2qm74	3357	3	BMMC	BMMC	NNP
cord-015021-pol2qm74	3357	4	released	release	VBD
cord-015021-pol2qm74	3357	5	histamine	histamine	NN
cord-015021-pol2qm74	3357	6	and	and	CC
cord-015021-pol2qm74	3357	7	serotoaln	serotoaln	NN
cord-015021-pol2qm74	3357	8	upon	upon	IN
cord-015021-pol2qm74	3357	9	challenge	challenge	NN
cord-015021-pol2qm74	3357	10	with	with	IN
cord-015021-pol2qm74	3357	11	ET-1.Furthermore	ET-1.Furthermore	NNP
cord-015021-pol2qm74	3357	12	,	,	,
cord-015021-pol2qm74	3357	13	ET-1	ET-1	NNP
cord-015021-pol2qm74	3357	14	stimulated	stimulate	VBD
cord-015021-pol2qm74	3357	15	LTC	LTC	NNP
cord-015021-pol2qm74	3357	16	4	4	CD
cord-015021-pol2qm74	3357	17	biosynthesis	biosynthesis	NN
cord-015021-pol2qm74	3357	18	up	up	IN
cord-015021-pol2qm74	3357	19	to	to	IN
cord-015021-pol2qm74	3357	20	4-fold	4-fold	CD
cord-015021-pol2qm74	3357	21	in	in	IN
cord-015021-pol2qm74	3357	22	BMMC	BMMC	NNP
cord-015021-pol2qm74	3357	23	cultured	culture	VBN
cord-015021-pol2qm74	3357	24	in	in	IN
cord-015021-pol2qm74	3357	25	the	the	DT
cord-015021-pol2qm74	3357	26	presence	presence	NN
cord-015021-pol2qm74	3357	27	of	of	IN
cord-015021-pol2qm74	3357	28	IL-4	IL-4	NNP
cord-015021-pol2qm74	3357	29	.	.	.
cord-015021-pol2qm74	3358	1	In	in	IN
cord-015021-pol2qm74	3358	2	contrast	contrast	NN
cord-015021-pol2qm74	3358	3	,	,	,
cord-015021-pol2qm74	3358	4	the	the	DT
cord-015021-pol2qm74	3358	5	peptide	peptide	NN
cord-015021-pol2qm74	3358	6	was	be	VBD
cord-015021-pol2qm74	3358	7	without	without	IN
cord-015021-pol2qm74	3358	8	major	major	JJ
cord-015021-pol2qm74	3358	9	effect	effect	NN
cord-015021-pol2qm74	3358	10	on	on	IN
cord-015021-pol2qm74	3358	11	LTC4	LTC4	NNP
cord-015021-pol2qm74	3358	12	biosynthesis	biosynthesis	NN
cord-015021-pol2qm74	3358	13	in	in	IN
cord-015021-pol2qm74	3358	14	BMMC	BMMC	NNP
cord-015021-pol2qm74	3358	15	culturd	culturd	NNP
cord-015021-pol2qm74	3358	16	without	without	IN
cord-015021-pol2qm74	3358	17	IL-4	IL-4	NNP
cord-015021-pol2qm74	3358	18	.	.	.
cord-015021-pol2qm74	3359	1	The	the	DT
cord-015021-pol2qm74	3359	2	release	release	NN
cord-015021-pol2qm74	3359	3	of	of	IN
cord-015021-pol2qm74	3359	4	histamine	histamine	NN
cord-015021-pol2qm74	3359	5	and	and	CC
cord-015021-pol2qm74	3359	6	sereotonin	sereotonin	NNP
cord-015021-pol2qm74	3359	7	was	be	VBD
cord-015021-pol2qm74	3359	8	not	not	RB
cord-015021-pol2qm74	3359	9	altered	alter	VBN
cord-015021-pol2qm74	3359	10	if	if	IN
cord-015021-pol2qm74	3359	11	BMMC	BMMC	NNP
cord-015021-pol2qm74	3359	12	were	be	VBD
cord-015021-pol2qm74	3359	13	preincubated	preincubate	VBN
cord-015021-pol2qm74	3359	14	for	for	IN
cord-015021-pol2qm74	3359	15	i	i	PRP
cord-015021-pol2qm74	3359	16	h	h	NNP
cord-015021-pol2qm74	3359	17	with	with	IN
cord-015021-pol2qm74	3359	18	IL-4	IL-4	NNP
cord-015021-pol2qm74	3359	19	prior	prior	RB
cord-015021-pol2qm74	3359	20	to	to	IN
cord-015021-pol2qm74	3359	21	activation	activation	NN
cord-015021-pol2qm74	3359	22	with	with	IN
cord-015021-pol2qm74	3359	23	ET	ET	NNP
cord-015021-pol2qm74	3359	24	-	-	:
cord-015021-pol2qm74	3359	25	I	I	NNP
cord-015021-pol2qm74	3359	26	,	,	,
cord-015021-pol2qm74	3359	27	suggesting	suggest	VBG
cord-015021-pol2qm74	3359	28	that	that	IN
cord-015021-pol2qm74	3359	29	a	a	DT
cord-015021-pol2qm74	3359	30	differentiation	differentiation	NN
cord-015021-pol2qm74	3359	31	process	process	NN
cord-015021-pol2qm74	3359	32	rather	rather	RB
cord-015021-pol2qm74	3359	33	than	than	IN
cord-015021-pol2qm74	3359	34	a	a	DT
cord-015021-pol2qm74	3359	35	functional	functional	JJ
cord-015021-pol2qm74	3359	36	priming	priming	NN
cord-015021-pol2qm74	3359	37	effect	effect	NN
cord-015021-pol2qm74	3359	38	had	have	VBD
cord-015021-pol2qm74	3359	39	been	be	VBN
cord-015021-pol2qm74	3359	40	initiated	initiate	VBN
cord-015021-pol2qm74	3359	41	by	by	IN
cord-015021-pol2qm74	3359	42	]	]	-RRB-
cord-015021-pol2qm74	3360	1	L-4	L-4	NNP
cord-015021-pol2qm74	3360	2	.	.	.
cord-015021-pol2qm74	3360	3	ET-1	ET-1	NNP
cord-015021-pol2qm74	3360	4	(	(	-LRB-
cord-015021-pol2qm74	3360	5	10"6	10"6	NNP
cord-015021-pol2qm74	3360	6	M	M	NNP
cord-015021-pol2qm74	3360	7	)	)	-RRB-
cord-015021-pol2qm74	3361	1	-induced	-induced	JJ
cord-015021-pol2qm74	3361	2	histamine	histamine	NN
cord-015021-pol2qm74	3361	3	and	and	CC
cord-015021-pol2qm74	3361	4	serotouln	serotouln	NNP
cord-015021-pol2qm74	3361	5	release	release	NN
cord-015021-pol2qm74	3361	6	from	from	IN
cord-015021-pol2qm74	3361	7	BMMC	BMMC	NNP
cord-015021-pol2qm74	3361	8	was	be	VBD
cord-015021-pol2qm74	3361	9	inhibited	inhibit	VBN
cord-015021-pol2qm74	3361	10	by	by	IN
cord-015021-pol2qm74	3361	11	an	an	DT
cord-015021-pol2qm74	3361	12	ETA	ETA	NNP
cord-015021-pol2qm74	3361	13	-	-	HYPH
cord-015021-pol2qm74	3361	14	specific	specific	JJ
cord-015021-pol2qm74	3361	15	antagonist	antagonist	NN
cord-015021-pol2qm74	3361	16	(	(	-LRB-
cord-015021-pol2qm74	3361	17	cyclic	cyclic	JJ
cord-015021-pol2qm74	3361	18	ID	ID	NNP
cord-015021-pol2qm74	3361	19	-	-	HYPH
cord-015021-pol2qm74	3361	20	Asp	Asp	NNP
cord-015021-pol2qm74	3361	21	-	-	HYPH
cord-015021-pol2qm74	3361	22	Pro	pro	JJ
cord-015021-pol2qm74	3361	23	-	-	JJ
cord-015021-pol2qm74	3361	24	D	d	JJ
cord-015021-pol2qm74	3361	25	-	-	HYPH
cord-015021-pol2qm74	3361	26	Val	Val	NNP
cord-015021-pol2qm74	3361	27	-	-	HYPH
cord-015021-pol2qm74	3361	28	Leu	Leu	NNP
cord-015021-pol2qm74	3361	29	-	-	HYPH
cord-015021-pol2qm74	3361	30	D	D	NNP
cord-015021-pol2qm74	3361	31	-	-	HYPH
cord-015021-pol2qm74	3361	32	Tel	Tel	NNP
cord-015021-pol2qm74	3361	33	)	)	-RRB-
cord-015021-pol2qm74	3361	34	in	in	IN
cord-015021-pol2qm74	3361	35	a	a	DT
cord-015021-pol2qm74	3361	36	dose	dose	NN
cord-015021-pol2qm74	3361	37	-	-	HYPH
cord-015021-pol2qm74	3361	38	dependent	dependent	JJ
cord-015021-pol2qm74	3361	39	manner	manner	NN
cord-015021-pol2qm74	3361	40	,	,	,
cord-015021-pol2qm74	3361	41	with	with	IN
cord-015021-pol2qm74	3361	42	a	a	DT
cord-015021-pol2qm74	3361	43	complete	complete	JJ
cord-015021-pol2qm74	3361	44	inhibition	inhibition	NN
cord-015021-pol2qm74	3361	45	observed	observe	VBD
cord-015021-pol2qm74	3361	46	at	at	IN
cord-015021-pol2qm74	3361	47	an	an	DT
cord-015021-pol2qm74	3361	48	antagonist	antagonist	NN
cord-015021-pol2qm74	3361	49	concentration	concentration	NN
cord-015021-pol2qm74	3361	50	of	of	IN
cord-015021-pol2qm74	3361	51	10	10	CD
cord-015021-pol2qm74	3361	52	-8	-8	NNP
cord-015021-pol2qm74	3361	53	M.	M.	NNP
cord-015021-pol2qm74	3361	54	Crude	Crude	NNP
cord-015021-pol2qm74	3361	55	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	3361	56	cells	cell	NNS
cord-015021-pol2qm74	3361	57	(	(	-LRB-
cord-015021-pol2qm74	3361	58	containing	contain	VBG
cord-015021-pol2qm74	3361	59	2	2	CD
cord-015021-pol2qm74	3361	60	-	-	SYM
cord-015021-pol2qm74	3361	61	3	3	CD
cord-015021-pol2qm74	3361	62	%	%	NN
cord-015021-pol2qm74	3361	63	serosal	serosal	NN
cord-015021-pol2qm74	3361	64	mast	mast	NN
cord-015021-pol2qm74	3361	65	cells	cell	NNS
cord-015021-pol2qm74	3361	66	)	)	-RRB-
cord-015021-pol2qm74	3361	67	obtained	obtain	VBD
cord-015021-pol2qm74	3361	68	from	from	IN
cord-015021-pol2qm74	3361	69	normal	normal	JJ
cord-015021-pol2qm74	3361	70	BALB	BALB	NNP
cord-015021-pol2qm74	3361	71	/	/	SYM
cord-015021-pol2qm74	3361	72	c	c	NNP
cord-015021-pol2qm74	3361	73	-	-	HYPH
cord-015021-pol2qm74	3361	74	mice	mouse	NNS
cord-015021-pol2qm74	3361	75	released	release	VBD
cord-015021-pol2qm74	3361	76	87	87	CD
cord-015021-pol2qm74	3361	77	%	%	NN
cord-015021-pol2qm74	3361	78	histamine	histamine	NN
cord-015021-pol2qm74	3361	79	upon	upon	IN
cord-015021-pol2qm74	3361	80	challenge	challenge	NN
cord-015021-pol2qm74	3361	81	with	with	IN
cord-015021-pol2qm74	3361	82	ET-1	ET-1	NNP
cord-015021-pol2qm74	3361	83	(	(	-LRB-
cord-015021-pol2qm74	3361	84	10	10	CD
cord-015021-pol2qm74	3361	85	-6	-6	NNP
cord-015021-pol2qm74	3361	86	M	M	NNP
cord-015021-pol2qm74	3361	87	;	;	:
cord-015021-pol2qm74	3361	88	20	20	CD
cord-015021-pol2qm74	3361	89	rain	rain	NN
cord-015021-pol2qm74	3361	90	)	)	-RRB-
cord-015021-pol2qm74	3361	91	.	.	.
cord-015021-pol2qm74	3362	1	Taken	take	VBN
cord-015021-pol2qm74	3362	2	together	together	RB
cord-015021-pol2qm74	3362	3	,	,	,
cord-015021-pol2qm74	3362	4	these	these	DT
cord-015021-pol2qm74	3362	5	resu	resu	NN
cord-015021-pol2qm74	3362	6	/	/	SYM
cord-015021-pol2qm74	3362	7	ts	t	NNS
cord-015021-pol2qm74	3362	8	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	3362	9	that	that	IN
cord-015021-pol2qm74	3362	10	ET-1	ET-1	NNP
cord-015021-pol2qm74	3362	11	can	can	MD
cord-015021-pol2qm74	3362	12	directly	directly	RB
cord-015021-pol2qm74	3362	13	function	function	VB
cord-015021-pol2qm74	3362	14	as	as	IN
cord-015021-pol2qm74	3362	15	a	a	DT
cord-015021-pol2qm74	3362	16	histamine	histamine	NN
cord-015021-pol2qm74	3362	17	and	and	CC
cord-015021-pol2qm74	3362	18	serotohin	serotohin	NNP
cord-015021-pol2qm74	3362	19	secretagogue	secretagogue	NNP
cord-015021-pol2qm74	3362	20	and	and	CC
cord-015021-pol2qm74	3362	21	as	as	IN
cord-015021-pol2qm74	3362	22	a	a	DT
cord-015021-pol2qm74	3362	23	stimulator	stimulator	NN
cord-015021-pol2qm74	3362	24	of	of	IN
cord-015021-pol2qm74	3362	25	LTC	LTC	NNP
cord-015021-pol2qm74	3362	26	4	4	CD
cord-015021-pol2qm74	3362	27	production	production	NN
cord-015021-pol2qm74	3362	28	in	in	IN
cord-015021-pol2qm74	3362	29	mast	mast	NN
cord-015021-pol2qm74	3362	30	cells	cell	NNS
cord-015021-pol2qm74	3362	31	.	.	.
cord-015021-pol2qm74	3363	1	IL-4	IL-4	NNP
cord-015021-pol2qm74	3363	2	appears	appear	VBZ
cord-015021-pol2qm74	3363	3	to	to	TO
cord-015021-pol2qm74	3363	4	be	be	VB
cord-015021-pol2qm74	3363	5	involved	involve	VBN
cord-015021-pol2qm74	3363	6	in	in	IN
cord-015021-pol2qm74	3363	7	the	the	DT
cord-015021-pol2qm74	3363	8	differentiation	differentiation	NN
cord-015021-pol2qm74	3363	9	of	of	IN
cord-015021-pol2qm74	3363	10	immature	immature	JJ
cord-015021-pol2qm74	3363	11	mast	mast	JJ
cord-015021-pol2qm74	3363	12	cell	cell	NN
cord-015021-pol2qm74	3363	13	prec	prec	NN
cord-015021-pol2qm74	3363	14	~	~	NFP
cord-015021-pol2qm74	3363	15	trsors	trsor	NNS
cord-015021-pol2qm74	3363	16	towards	towards	IN
cord-015021-pol2qm74	3363	17	an	an	DT
cord-015021-pol2qm74	3363	18	ET	ET	NNP
cord-015021-pol2qm74	3363	19	-	-	HYPH
cord-015021-pol2qm74	3363	20	l	l	NN
cord-015021-pol2qm74	3363	21	-	-	HYPH
cord-015021-pol2qm74	3363	22	reactive	reactive	JJ
cord-015021-pol2qm74	3363	23	functional	functional	JJ
cord-015021-pol2qm74	3363	24	phenotype	phenotype	NN
cord-015021-pol2qm74	3363	25	.	.	.
cord-015021-pol2qm74	3364	1	When	when	WRB
cord-015021-pol2qm74	3364	2	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3364	3	reactions	reaction	NNS
cord-015021-pol2qm74	3364	4	are	be	VBP
cord-015021-pol2qm74	3364	5	advanced	advanced	JJ
cord-015021-pol2qm74	3364	6	,	,	,
cord-015021-pol2qm74	3364	7	type	type	NN
cord-015021-pol2qm74	3364	8	II	II	NNP
cord-015021-pol2qm74	3364	9	phospholipase	phospholipase	NN
cord-015021-pol2qm74	3364	10	A2	A2	NNP
cord-015021-pol2qm74	3364	11	(	(	-LRB-
cord-015021-pol2qm74	3364	12	type	type	NN
cord-015021-pol2qm74	3364	13	II	II	NNP
cord-015021-pol2qm74	3364	14	PLA2	PLA2	NNP
cord-015021-pol2qm74	3364	15	)	)	-RRB-
cord-015021-pol2qm74	3364	16	is	be	VBZ
cord-015021-pol2qm74	3364	17	produced	produce	VBN
cord-015021-pol2qm74	3364	18	in	in	IN
cord-015021-pol2qm74	3364	19	high	high	JJ
cord-015021-pol2qm74	3364	20	levels	level	NNS
cord-015021-pol2qm74	3364	21	by	by	IN
cord-015021-pol2qm74	3364	22	various	various	JJ
cord-015021-pol2qm74	3364	23	cells	cell	NNS
cord-015021-pol2qm74	3364	24	at	at	IN
cord-015021-pol2qm74	3364	25	the	the	DT
cord-015021-pol2qm74	3364	26	site	site	NN
cord-015021-pol2qm74	3364	27	of	of	IN
cord-015021-pol2qm74	3364	28	inflammation	inflammation	NN
cord-015021-pol2qm74	3364	29	.	.	.
cord-015021-pol2qm74	3365	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	3365	2	such	such	JJ
cord-015021-pol2qm74	3365	3	as	as	IN
cord-015021-pol2qm74	3365	4	TNF	TNF	NNP
cord-015021-pol2qm74	3365	5	-	-	:
cord-015021-pol2qm74	3365	6	a	a	NN
cord-015021-pol2qm74	3365	7	and	and	CC
cord-015021-pol2qm74	3366	1	IL	IL	NNP
cord-015021-pol2qm74	3366	2	-	-	:
cord-015021-pol2qm74	3366	3	I	-PRON-	PRP
cord-015021-pol2qm74	3366	4	activate	activate	VBP
cord-015021-pol2qm74	3366	5	type	type	NN
cord-015021-pol2qm74	3366	6	II	II	NNP
cord-015021-pol2qm74	3366	7	PLA2	PLA2	NNP
cord-015021-pol2qm74	3366	8	and	and	CC
cord-015021-pol2qm74	3366	9	promote	promote	VB
cord-015021-pol2qm74	3366	10	the	the	DT
cord-015021-pol2qm74	3366	11	production	production	NN
cord-015021-pol2qm74	3366	12	of	of	IN
cord-015021-pol2qm74	3366	13	eicosanoid	eicosanoid	NNP
cord-015021-pol2qm74	3366	14	,	,	,
cord-015021-pol2qm74	3366	15	which	which	WDT
cord-015021-pol2qm74	3366	16	is	be	VBZ
cord-015021-pol2qm74	3366	17	one	one	CD
cord-015021-pol2qm74	3366	18	of	of	IN
cord-015021-pol2qm74	3366	19	the	the	DT
cord-015021-pol2qm74	3366	20	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3366	21	by	by	IN
cord-015021-pol2qm74	3366	22	which	which	WDT
cord-015021-pol2qm74	3366	23	they	-PRON-	PRP
cord-015021-pol2qm74	3366	24	enhance	enhance	VBP
cord-015021-pol2qm74	3366	25	the	the	DT
cord-015021-pol2qm74	3366	26	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3366	27	reaction	reaction	NN
cord-015021-pol2qm74	3366	28	.	.	.
cord-015021-pol2qm74	3367	1	In	in	IN
cord-015021-pol2qm74	3367	2	the	the	DT
cord-015021-pol2qm74	3367	3	present	present	JJ
cord-015021-pol2qm74	3367	4	study	study	NN
cord-015021-pol2qm74	3367	5	,	,	,
cord-015021-pol2qm74	3367	6	the	the	DT
cord-015021-pol2qm74	3367	7	blood	blood	NN
cord-015021-pol2qm74	3367	8	levels	level	NNS
cord-015021-pol2qm74	3367	9	of	of	IN
cord-015021-pol2qm74	3367	10	type	type	NN
cord-015021-pol2qm74	3367	11	II	II	NNP
cord-015021-pol2qm74	3367	12	PEA2	PEA2	NNP
cord-015021-pol2qm74	3367	13	,	,	,
cord-015021-pol2qm74	3367	14	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3367	15	,	,	.
cord-015021-pol2qm74	3368	1	TNF	TNF	NNP
cord-015021-pol2qm74	3368	2	-	-	HYPH
cord-015021-pol2qm74	3368	3	c~	c~	NNP
cord-015021-pol2qm74	3368	4	,	,	,
cord-015021-pol2qm74	3369	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3369	2	and	and	CC
cord-015021-pol2qm74	3369	3	IL-8	IL-8	NNP
cord-015021-pol2qm74	3369	4	were	be	VBD
cord-015021-pol2qm74	3369	5	determined	determine	VBN
cord-015021-pol2qm74	3369	6	in	in	IN
cord-015021-pol2qm74	3369	7	patients	patient	NNS
cord-015021-pol2qm74	3369	8	with	with	IN
cord-015021-pol2qm74	3369	9	sepsis	sepsis	NN
cord-015021-pol2qm74	3369	10	to	to	TO
cord-015021-pol2qm74	3369	11	examine	examine	VB
cord-015021-pol2qm74	3369	12	the	the	DT
cord-015021-pol2qm74	3369	13	relationship	relationship	NN
cord-015021-pol2qm74	3369	14	between	between	IN
cord-015021-pol2qm74	3369	15	these	these	DT
cord-015021-pol2qm74	3369	16	levels	level	NNS
cord-015021-pol2qm74	3369	17	and	and	CC
cord-015021-pol2qm74	3369	18	the	the	DT
cord-015021-pol2qm74	3369	19	patients	patient	NNS
cord-015021-pol2qm74	3369	20	'	'	POS
cord-015021-pol2qm74	3369	21	pathological	pathological	JJ
cord-015021-pol2qm74	3369	22	conditions	condition	NNS
cord-015021-pol2qm74	3369	23	.	.	.
cord-015021-pol2qm74	3370	1	The	the	DT
cord-015021-pol2qm74	3370	2	levels	level	NNS
cord-015021-pol2qm74	3370	3	of	of	IN
cord-015021-pol2qm74	3370	4	type	type	NN
cord-015021-pol2qm74	3370	5	II	II	NNP
cord-015021-pol2qm74	3370	6	PLA2	PLA2	NNP
cord-015021-pol2qm74	3370	7	and	and	CC
cord-015021-pol2qm74	3370	8	TNF	TNF	NNP
cord-015021-pol2qm74	3370	9	-	-	,
cord-015021-pol2qm74	3370	10	a	a	NN
cord-015021-pol2qm74	3370	11	in	in	IN
cord-015021-pol2qm74	3370	12	these	these	DT
cord-015021-pol2qm74	3370	13	patients	patient	NNS
cord-015021-pol2qm74	3370	14	were	be	VBD
cord-015021-pol2qm74	3370	15	218.3	218.3	CD
cord-015021-pol2qm74	3370	16	±	±	CD
cord-015021-pol2qm74	3370	17	179.9	179.9	CD
cord-015021-pol2qm74	3370	18	ng	ng	NNP
cord-015021-pol2qm74	3370	19	/	/	SYM
cord-015021-pol2qm74	3370	20	ml	ml	NN
cord-015021-pol2qm74	3370	21	and	and	CC
cord-015021-pol2qm74	3370	22	98.5	98.5	CD
cord-015021-pol2qm74	3370	23	±	±	NNP
cord-015021-pol2qm74	3370	24	92.1	92.1	CD
cord-015021-pol2qm74	3370	25	pg	pg	NNP
cord-015021-pol2qm74	3370	26	/	/	SYM
cord-015021-pol2qm74	3370	27	ml	ml	NNS
cord-015021-pol2qm74	3370	28	,	,	,
cord-015021-pol2qm74	3370	29	respectively	respectively	RB
cord-015021-pol2qm74	3370	30	,	,	,
cord-015021-pol2qm74	3370	31	the	the	DT
cord-015021-pol2qm74	3370	32	two	two	CD
cord-015021-pol2qm74	3370	33	parameters	parameter	NNS
cord-015021-pol2qm74	3370	34	being	be	VBG
cord-015021-pol2qm74	3370	35	significantly	significantly	RB
cord-015021-pol2qm74	3370	36	correlated	correlate	VBN
cord-015021-pol2qm74	3370	37	(	(	-LRB-
cord-015021-pol2qm74	3370	38	r	r	NN
cord-015021-pol2qm74	3370	39	=	=	SYM
cord-015021-pol2qm74	3370	40	0.6460	0.6460	CD
cord-015021-pol2qm74	3370	41	,	,	,
cord-015021-pol2qm74	3370	42	p	p	NN
cord-015021-pol2qm74	3370	43	=	=	SYM
cord-015021-pol2qm74	3370	44	0.0001	0.0001	CD
cord-015021-pol2qm74	3370	45	)	)	-RRB-
cord-015021-pol2qm74	3370	46	.	.	.
cord-015021-pol2qm74	3371	1	There	there	EX
cord-015021-pol2qm74	3371	2	were	be	VBD
cord-015021-pol2qm74	3371	3	also	also	RB
cord-015021-pol2qm74	3371	4	a	a	DT
cord-015021-pol2qm74	3371	5	significant	significant	JJ
cord-015021-pol2qm74	3371	6	correlation	correlation	NN
cord-015021-pol2qm74	3371	7	between	between	IN
cord-015021-pol2qm74	3371	8	the	the	DT
cord-015021-pol2qm74	3371	9	level	level	NN
cord-015021-pol2qm74	3371	10	of	of	IN
cord-015021-pol2qm74	3371	11	type	type	NN
cord-015021-pol2qm74	3371	12	II	II	NNP
cord-015021-pol2qm74	3371	13	PLA2	PLA2	NNP
cord-015021-pol2qm74	3371	14	an	an	DT
cord-015021-pol2qm74	3371	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	3371	16	(	(	-LRB-
cord-015021-pol2qm74	3371	17	r	r	NN
cord-015021-pol2qm74	3371	18	=	=	SYM
cord-015021-pol2qm74	3371	19	0.4262	0.4262	CD
cord-015021-pol2qm74	3371	20	,	,	,
cord-015021-pol2qm74	3371	21	p	p	NN
cord-015021-pol2qm74	3371	22	=	=	SYM
cord-015021-pol2qm74	3371	23	0.0188	0.0188	CD
cord-015021-pol2qm74	3371	24	)	)	-RRB-
cord-015021-pol2qm74	3371	25	.	.	.
cord-015021-pol2qm74	3372	1	There	there	EX
cord-015021-pol2qm74	3372	2	was	be	VBD
cord-015021-pol2qm74	3372	3	no	no	DT
cord-015021-pol2qm74	3372	4	significant	significant	JJ
cord-015021-pol2qm74	3372	5	correlation	correlation	NN
cord-015021-pol2qm74	3372	6	between	between	IN
cord-015021-pol2qm74	3372	7	the	the	DT
cord-015021-pol2qm74	3372	8	level	level	NN
cord-015021-pol2qm74	3372	9	of	of	IN
cord-015021-pol2qm74	3372	10	type	type	NN
cord-015021-pol2qm74	3372	11	II	II	NNP
cord-015021-pol2qm74	3372	12	PLA2	PLA2	NNP
cord-015021-pol2qm74	3372	13	and	and	CC
cord-015021-pol2qm74	3372	14	IL-8	IL-8	NNP
cord-015021-pol2qm74	3372	15	.	.	.
cord-015021-pol2qm74	3373	1	These	these	DT
cord-015021-pol2qm74	3373	2	in	in	IN
cord-015021-pol2qm74	3373	3	vivo	vivo	NN
cord-015021-pol2qm74	3373	4	findings	finding	NNS
cord-015021-pol2qm74	3373	5	suggest	suggest	VBP
cord-015021-pol2qm74	3373	6	that	that	IN
cord-015021-pol2qm74	3373	7	TNF	TNF	NNP
cord-015021-pol2qm74	3373	8	-	-	:
cord-015021-pol2qm74	3373	9	a	a	DT
cord-015021-pol2qm74	3373	10	may	may	MD
cord-015021-pol2qm74	3373	11	be	be	VB
cord-015021-pol2qm74	3373	12	involved	involve	VBN
cord-015021-pol2qm74	3373	13	in	in	IN
cord-015021-pol2qm74	3373	14	the	the	DT
cord-015021-pol2qm74	3373	15	production	production	NN
cord-015021-pol2qm74	3373	16	of	of	IN
cord-015021-pol2qm74	3373	17	type	type	NN
cord-015021-pol2qm74	3373	18	II	II	NNP
cord-015021-pol2qm74	3373	19	PLA2	PLA2	NNP
cord-015021-pol2qm74	3373	20	.	.	.
cord-015021-pol2qm74	3373	21	 	 	_SP
cord-015021-pol2qm74	3374	1	A.	A.	NNP
cord-015021-pol2qm74	3374	2	Filzmaver	Filzmaver	NNP
cord-015021-pol2qm74	3374	3	,	,	,
cord-015021-pol2qm74	3374	4	G.	G.	NNP
cord-015021-pol2qm74	3374	5	Reisbach	Reisbach	NNP
cord-015021-pol2qm74	3374	6	,	,	,
cord-015021-pol2qm74	3374	7	E.	E.	NNP
cord-015021-pol2qm74	3374	8	Schmitt	Schmitt	NNP
cord-015021-pol2qm74	3374	9	°	°	NN
cord-015021-pol2qm74	3374	10	,	,	,
cord-015021-pol2qm74	3374	11	R.	R.	NNP
cord-015021-pol2qm74	3374	12	Mailhammer	Mailhammer	NNP
cord-015021-pol2qm74	3374	13	,	,	,
cord-015021-pol2qm74	3374	14	and	and	CC
cord-015021-pol2qm74	3374	15	L.	L.	NNP
cord-015021-pol2qm74	3374	16	Hiittner	Hiittner	NNP
cord-015021-pol2qm74	3374	17	.	.	.
cord-015021-pol2qm74	3375	1	GSF	GSF	NNP
cord-015021-pol2qm74	3375	2	-	-	HYPH
cord-015021-pol2qm74	3375	3	Iustitut	Iustitut	NNP
cord-015021-pol2qm74	3375	4	ff	ff	NN
cord-015021-pol2qm74	3376	1	~r	~r	XX
cord-015021-pol2qm74	3376	2	Experimentelle	Experimentelle	NNP
cord-015021-pol2qm74	3376	3	H	H	NNP
cord-015021-pol2qm74	3376	4	~	~	NFP
cord-015021-pol2qm74	3376	5	imatologie	imatologie	NN
cord-015021-pol2qm74	3376	6	,	,	,
cord-015021-pol2qm74	3376	7	Munich	Munich	NNP
cord-015021-pol2qm74	3376	8	,	,	,
cord-015021-pol2qm74	3376	9	and	and	CC
cord-015021-pol2qm74	3376	10	°	°	NNP
cord-015021-pol2qm74	3376	11	Iustitut	Iustitut	NNP
cord-015021-pol2qm74	3376	12	fttr	fttr	NN
cord-015021-pol2qm74	3376	13	Immunelone	Immunelone	NNP
cord-015021-pol2qm74	3376	14	,	,	,
cord-015021-pol2qm74	3376	15	Johannes	Johannes	NNP
cord-015021-pol2qm74	3376	16	Gutenberg	Gutenberg	NNP
cord-015021-pol2qm74	3376	17	Universit	Universit	NNP
cord-015021-pol2qm74	3377	1	~t	~t	NNP
cord-015021-pol2qm74	3377	2	,	,	,
cord-015021-pol2qm74	3377	3	Mainz	Mainz	NNP
cord-015021-pol2qm74	3377	4	,	,	,
cord-015021-pol2qm74	3377	5	Germany	Germany	NNP
cord-015021-pol2qm74	3378	1	The	the	DT
cord-015021-pol2qm74	3378	2	product	product	NN
cord-015021-pol2qm74	3378	3	of	of	IN
cord-015021-pol2qm74	3378	4	c	c	NN
cord-015021-pol2qm74	3378	5	-	-	HYPH
cord-015021-pol2qm74	3378	6	kit	kit	NN
cord-015021-pol2qm74	3378	7	,	,	,
cord-015021-pol2qm74	3378	8	a	a	DT
cord-015021-pol2qm74	3378	9	transmembrane	transmembrane	NNP
cord-015021-pol2qm74	3378	10	tyrosin	tyrosin	NNP
cord-015021-pol2qm74	3378	11	ldnase	ldnase	NNP
cord-015021-pol2qm74	3378	12	receptor	receptor	NN
cord-015021-pol2qm74	3378	13	,	,	,
cord-015021-pol2qm74	3378	14	and	and	CC
cord-015021-pol2qm74	3378	15	a	a	DT
cord-015021-pol2qm74	3378	16	corresponding	correspond	VBG
cord-015021-pol2qm74	3378	17	kit	kit	NN
cord-015021-pol2qm74	3378	18	ligand	ligand	NN
cord-015021-pol2qm74	3378	19	(	(	-LRB-
cord-015021-pol2qm74	3378	20	KL	KL	NNP
cord-015021-pol2qm74	3378	21	)	)	-RRB-
cord-015021-pol2qm74	3378	22	are	be	VBP
cord-015021-pol2qm74	3378	23	critically	critically	RB
cord-015021-pol2qm74	3378	24	involved	involve	VBN
cord-015021-pol2qm74	3378	25	in	in	IN
cord-015021-pol2qm74	3378	26	the	the	DT
cord-015021-pol2qm74	3378	27	control	control	NN
cord-015021-pol2qm74	3378	28	of	of	IN
cord-015021-pol2qm74	3378	29	different	different	JJ
cord-015021-pol2qm74	3378	30	hemopoietic	hemopoietic	JJ
cord-015021-pol2qm74	3378	31	cell	cell	NN
cord-015021-pol2qm74	3378	32	lineages	lineage	NNS
cord-015021-pol2qm74	3378	33	including	include	VBG
cord-015021-pol2qm74	3378	34	the	the	DT
cord-015021-pol2qm74	3378	35	proliferation	proliferation	NN
cord-015021-pol2qm74	3378	36	,	,	,
cord-015021-pol2qm74	3378	37	maturation	maturation	NN
cord-015021-pol2qm74	3378	38	,	,	,
cord-015021-pol2qm74	3378	39	migration	migration	NN
cord-015021-pol2qm74	3378	40	,	,	,
cord-015021-pol2qm74	3378	41	and	and	CC
cord-015021-pol2qm74	3378	42	function	function	NN
cord-015021-pol2qm74	3378	43	of	of	IN
cord-015021-pol2qm74	3378	44	mast	mast	NN
cord-015021-pol2qm74	3378	45	cells	cell	NNS
cord-015021-pol2qm74	3378	46	.	.	.
cord-015021-pol2qm74	3379	1	It	-PRON-	PRP
cord-015021-pol2qm74	3379	2	has	have	VBZ
cord-015021-pol2qm74	3379	3	been	be	VBN
cord-015021-pol2qm74	3379	4	reported	report	VBN
cord-015021-pol2qm74	3379	5	previously	previously	RB
cord-015021-pol2qm74	3379	6	that	that	IN
cord-015021-pol2qm74	3379	7	interleukin	interleukin	NN
cord-015021-pol2qm74	3379	8	(	(	-LRB-
cord-015021-pol2qm74	3379	9	IL)-4	IL)-4	NNP
cord-015021-pol2qm74	3379	10	down	down	RB
cord-015021-pol2qm74	3379	11	-	-	HYPH
cord-015021-pol2qm74	3379	12	regulates	regulates	NN
cord-015021-pol2qm74	3379	13	kit	kit	NN
cord-015021-pol2qm74	3379	14	receptors	receptor	NNS
cord-015021-pol2qm74	3379	15	in	in	IN
cord-015021-pol2qm74	3379	16	human	human	JJ
cord-015021-pol2qm74	3379	17	primary	primary	JJ
cord-015021-pol2qm74	3379	18	myeloid	myeloid	JJ
cord-015021-pol2qm74	3379	19	leukemic	leukemic	JJ
cord-015021-pol2qm74	3379	20	cells	cell	NNS
cord-015021-pol2qm74	3379	21	and	and	CC
cord-015021-pol2qm74	3379	22	in	in	IN
cord-015021-pol2qm74	3379	23	a	a	DT
cord-015021-pol2qm74	3379	24	human	human	JJ
cord-015021-pol2qm74	3379	25	mast	mast	NN
cord-015021-pol2qm74	3379	26	celt	celt	NN
cord-015021-pol2qm74	3379	27	line	line	NN
cord-015021-pol2qm74	3379	28	(	(	-LRB-
cord-015021-pol2qm74	3379	29	Sinaber	Sinaber	NNP
cord-015021-pol2qm74	3379	30	et	et	FW
cord-015021-pol2qm74	3379	31	al	al	NNP
cord-015021-pol2qm74	3379	32	.	.	.
cord-015021-pol2qm74	3380	1	1991	1991	CD
cord-015021-pol2qm74	3380	2	,	,	,
cord-015021-pol2qm74	3380	3	J.	J.	NNP
cord-015021-pol2qm74	3380	4	Immunol	Immunol	NNP
cord-015021-pol2qm74	3380	5	.	.	.
cord-015021-pol2qm74	3380	6	147	147	CD
cord-015021-pol2qm74	3380	7	:	:	:
cord-015021-pol2qm74	3380	8	4224	4224	CD
cord-015021-pol2qm74	3380	9	)	)	-RRB-
cord-015021-pol2qm74	3380	10	.	.	.
cord-015021-pol2qm74	3381	1	Transforming	transform	VBG
cord-015021-pol2qm74	3381	2	growth	growth	NN
cord-015021-pol2qm74	3381	3	factor	factor	NN
cord-015021-pol2qm74	3381	4	(	(	-LRB-
cord-015021-pol2qm74	3381	5	TGF	TGF	NNP
cord-015021-pol2qm74	3381	6	)	)	-RRB-
cord-015021-pol2qm74	3381	7	gl	gl	NNP
cord-015021-pol2qm74	3381	8	,	,	,
cord-015021-pol2qm74	3381	9	was	be	VBD
cord-015021-pol2qm74	3381	10	also	also	RB
cord-015021-pol2qm74	3381	11	found	find	VBN
cord-015021-pol2qm74	3381	12	to	to	IN
cord-015021-pol2qm74	3381	13	down	down	RB
cord-015021-pol2qm74	3381	14	-	-	HYPH
cord-015021-pol2qm74	3381	15	modulate	modulate	VB
cord-015021-pol2qm74	3381	16	c	c	NN
cord-015021-pol2qm74	3381	17	-	-	HYPH
cord-015021-pol2qm74	3381	18	kit	kit	NN
cord-015021-pol2qm74	3381	19	mRNA	mRNA	NNP
cord-015021-pol2qm74	3381	20	and	and	CC
cord-015021-pol2qm74	3381	21	kit	kit	NN
cord-015021-pol2qm74	3381	22	receptor	receptor	NN
cord-015021-pol2qm74	3381	23	proteins	protein	NNS
cord-015021-pol2qm74	3381	24	in	in	IN
cord-015021-pol2qm74	3381	25	human	human	JJ
cord-015021-pol2qm74	3381	26	AML	AML	NNP
cord-015021-pol2qm74	3381	27	blasts	blast	NNS
cord-015021-pol2qm74	3381	28	,	,	,
cord-015021-pol2qm74	3381	29	a	a	DT
cord-015021-pol2qm74	3381	30	mechanism	mechanism	NN
cord-015021-pol2qm74	3381	31	probabely	probabely	RB
cord-015021-pol2qm74	3381	32	contributing	contribute	VBG
cord-015021-pol2qm74	3381	33	to	to	IN
cord-015021-pol2qm74	3381	34	the	the	DT
cord-015021-pol2qm74	3381	35	anti	anti	JJ
cord-015021-pol2qm74	3381	36	-	-	JJ
cord-015021-pol2qm74	3381	37	proliferative	proliferative	JJ
cord-015021-pol2qm74	3381	38	effect	effect	NN
cord-015021-pol2qm74	3381	39	of	of	IN
cord-015021-pol2qm74	3381	40	TGFIH	TGFIH	NNP
cord-015021-pol2qm74	3381	41	on	on	IN
cord-015021-pol2qm74	3381	42	KL	KL	NNP
cord-015021-pol2qm74	3381	43	-	-	HYPH
cord-015021-pol2qm74	3381	44	stimulated	stimulate	VBN
cord-015021-pol2qm74	3381	45	AML	AML	NNP
cord-015021-pol2qm74	3381	46	ceils	ceil	NNS
cord-015021-pol2qm74	3381	47	in	in	IN
cord-015021-pol2qm74	3381	48	vitro	vitro	FW
cord-015021-pol2qm74	3381	49	(	(	-LRB-
cord-015021-pol2qm74	3381	50	de	de	FW
cord-015021-pol2qm74	3381	51	Vos	vos	FW
cord-015021-pol2qm74	3381	52	et	et	FW
cord-015021-pol2qm74	3381	53	at	at	IN
cord-015021-pol2qm74	3381	54	.	.	.
cord-015021-pol2qm74	3381	55	1993	1993	CD
cord-015021-pol2qm74	3381	56	,	,	,
cord-015021-pol2qm74	3381	57	Cancer	Cancer	NNP
cord-015021-pol2qm74	3381	58	Res	Res	NNP
cord-015021-pol2qm74	3381	59	.	.	NNP
cord-015021-pol2qm74	3381	60	53	53	CD
cord-015021-pol2qm74	3381	61	:	:	:
cord-015021-pol2qm74	3381	62	3638	3638	CD
cord-015021-pol2qm74	3381	63	)	)	-RRB-
cord-015021-pol2qm74	3381	64	.	.	.
cord-015021-pol2qm74	3382	1	In	in	IN
cord-015021-pol2qm74	3382	2	porcine	porcine	JJ
cord-015021-pol2qm74	3382	3	endothelial	endothelial	JJ
cord-015021-pol2qm74	3382	4	cells	cell	NNS
cord-015021-pol2qm74	3382	5	transfected	transfecte	VBN
cord-015021-pol2qm74	3382	6	with	with	IN
cord-015021-pol2qm74	3382	7	a	a	DT
cord-015021-pol2qm74	3382	8	retroviral	retroviral	NN
cord-015021-pol2qm74	3382	9	construct	construct	NN
cord-015021-pol2qm74	3382	10	carrying	carry	VBG
cord-015021-pol2qm74	3382	11	the	the	DT
cord-015021-pol2qm74	3382	12	human	human	NN
cord-015021-pol2qm74	3382	13	(	(	-LRB-
cord-015021-pol2qm74	3382	14	hu	hu	NNP
cord-015021-pol2qm74	3382	15	)	)	-RRB-
cord-015021-pol2qm74	3382	16	e	e	LS
cord-015021-pol2qm74	3382	17	-	-	HYPH
cord-015021-pol2qm74	3382	18	kit	kit	NN
cord-015021-pol2qm74	3382	19	gena	gena	NNP
cord-015021-pol2qm74	3382	20	,	,	,
cord-015021-pol2qm74	3382	21	exogenous	exogenous	JJ
cord-015021-pol2qm74	3382	22	hu	hu	NNP
cord-015021-pol2qm74	3382	23	KL	KL	NNP
cord-015021-pol2qm74	3383	1	transiently	transiently	RB
cord-015021-pol2qm74	3383	2	down	down	RB
cord-015021-pol2qm74	3383	3	-	-	HYPH
cord-015021-pol2qm74	3383	4	regulated	regulate	VBN
cord-015021-pol2qm74	3383	5	kit	kit	NN
cord-015021-pol2qm74	3383	6	receptors	receptor	NNS
cord-015021-pol2qm74	3383	7	(	(	-LRB-
cord-015021-pol2qm74	3383	8	Blume	Blume	NNP
cord-015021-pol2qm74	3383	9	-	-	HYPH
cord-015021-pol2qm74	3383	10	Jeusen	Jeusen	NNP
cord-015021-pol2qm74	3383	11	et	et	NNP
cord-015021-pol2qm74	3383	12	al	al	NNP
cord-015021-pol2qm74	3383	13	.	.	.
cord-015021-pol2qm74	3384	1	1991	1991	CD
cord-015021-pol2qm74	3384	2	,	,	,
cord-015021-pol2qm74	3384	3	EMBO	EMBO	NNP
cord-015021-pol2qm74	3384	4	J	J	NNP
cord-015021-pol2qm74	3384	5	10	10	CD
cord-015021-pol2qm74	3384	6	:	:	:
cord-015021-pol2qm74	3384	7	4121	4121	CD
cord-015021-pol2qm74	3384	8	)	)	-RRB-
cord-015021-pol2qm74	3384	9	.	.	.
cord-015021-pol2qm74	3385	1	In	in	IN
cord-015021-pol2qm74	3385	2	the	the	DT
cord-015021-pol2qm74	3385	3	light	light	NN
cord-015021-pol2qm74	3385	4	of	of	IN
cord-015021-pol2qm74	3385	5	these	these	DT
cord-015021-pol2qm74	3385	6	previous	previous	JJ
cord-015021-pol2qm74	3385	7	findings	finding	NNS
cord-015021-pol2qm74	3385	8	we	-PRON-	PRP
cord-015021-pol2qm74	3385	9	analyzed	analyze	VBD
cord-015021-pol2qm74	3385	10	the	the	DT
cord-015021-pol2qm74	3385	11	effects	effect	NNS
cord-015021-pol2qm74	3385	12	of	of	IN
cord-015021-pol2qm74	3385	13	these	these	DT
cord-015021-pol2qm74	3385	14	exogenously	exogenously	RB
cord-015021-pol2qm74	3385	15	applied	apply	VBN
cord-015021-pol2qm74	3385	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	3385	17	(	(	-LRB-
cord-015021-pol2qm74	3385	18	IL-4	IL-4	NNP
cord-015021-pol2qm74	3385	19	,	,	,
cord-015021-pol2qm74	3385	20	TGFgl	TGFgl	NNP
cord-015021-pol2qm74	3385	21	,	,	,
cord-015021-pol2qm74	3385	22	KL	KL	NNP
cord-015021-pol2qm74	3385	23	)	)	-RRB-
cord-015021-pol2qm74	3385	24	on	on	IN
cord-015021-pol2qm74	3385	25	kit	kit	NN
cord-015021-pol2qm74	3385	26	receptor	receptor	NN
cord-015021-pol2qm74	3385	27	expression	expression	NN
cord-015021-pol2qm74	3385	28	and	and	CC
cord-015021-pol2qm74	3385	29	KL	kl	NN
cord-015021-pol2qm74	3385	30	-	-	HYPH
cord-015021-pol2qm74	3385	31	mediated	mediate	VBN
cord-015021-pol2qm74	3385	32	proliferation	proliferation	NN
cord-015021-pol2qm74	3385	33	and	and	CC
cord-015021-pol2qm74	3385	34	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	3385	35	migration	migration	NN
cord-015021-pol2qm74	3385	36	of	of	IN
cord-015021-pol2qm74	3385	37	primary	primary	JJ
cord-015021-pol2qm74	3385	38	mouse	mouse	NN
cord-015021-pol2qm74	3385	39	bone	bone	NN
cord-015021-pol2qm74	3385	40	marrow	marrow	NN
cord-015021-pol2qm74	3385	41	-	-	HYPH
cord-015021-pol2qm74	3385	42	derived	derive	VBN
cord-015021-pol2qm74	3385	43	mast	mast	NN
cord-015021-pol2qm74	3385	44	cells	cell	NNS
cord-015021-pol2qm74	3385	45	(	(	-LRB-
cord-015021-pol2qm74	3385	46	BMMC	BMMC	NNP
cord-015021-pol2qm74	3385	47	)	)	-RRB-
cord-015021-pol2qm74	3386	1	(	(	-LRB-
cord-015021-pol2qm74	3386	2	in	in	IN
cord-015021-pol2qm74	3386	3	vitro	vitro	FW
cord-015021-pol2qm74	3386	4	age	age	NN
cord-015021-pol2qm74	3386	5	:	:	:
cord-015021-pol2qm74	3386	6	4	4	CD
cord-015021-pol2qm74	3386	7	weeks	week	NNS
cord-015021-pol2qm74	3386	8	)	)	-RRB-
cord-015021-pol2qm74	3386	9	.	.	.
cord-015021-pol2qm74	3387	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3387	2	results	result	NNS
cord-015021-pol2qm74	3387	3	show	show	VBP
cord-015021-pol2qm74	3387	4	that	that	IN
cord-015021-pol2qm74	3387	5	in	in	IN
cord-015021-pol2qm74	3387	6	BMMC	BMMC	NNP
cord-015021-pol2qm74	3387	7	cultures	culture	NNS
cord-015021-pol2qm74	3387	8	initiated	initiate	VBN
cord-015021-pol2qm74	3387	9	with	with	IN
cord-015021-pol2qm74	3387	10	recombinant	recombinant	JJ
cord-015021-pol2qm74	3387	11	(	(	-LRB-
cord-015021-pol2qm74	3387	12	r	r	NN
cord-015021-pol2qm74	3387	13	)	)	-RRB-
cord-015021-pol2qm74	3387	14	marine	marine	JJ
cord-015021-pol2qm74	3387	15	(	(	-LRB-
cord-015021-pol2qm74	3387	16	mu	mu	NN
cord-015021-pol2qm74	3387	17	)	)	-RRB-
cord-015021-pol2qm74	3388	1	IL-3	IL-3	NNP
cord-015021-pol2qm74	3389	1	the	the	DT
cord-015021-pol2qm74	3389	2	additional	additional	JJ
cord-015021-pol2qm74	3389	3	presence	presence	NN
cord-015021-pol2qm74	3389	4	of	of	IN
cord-015021-pol2qm74	3389	5	rmulL-4	rmulL-4	NNP
cord-015021-pol2qm74	3389	6	for	for	IN
cord-015021-pol2qm74	3389	7	3	3	CD
cord-015021-pol2qm74	3389	8	or	or	CC
cord-015021-pol2qm74	3389	9	14	14	CD
cord-015021-pol2qm74	3389	10	days	day	NNS
cord-015021-pol2qm74	3389	11	did	do	VBD
cord-015021-pol2qm74	3389	12	not	not	RB
cord-015021-pol2qm74	3389	13	change	change	VB
cord-015021-pol2qm74	3389	14	the	the	DT
cord-015021-pol2qm74	3389	15	expression	expression	NN
cord-015021-pol2qm74	3389	16	of	of	IN
cord-015021-pol2qm74	3389	17	kit	kit	NN
cord-015021-pol2qm74	3389	18	protein	protein	NN
cord-015021-pol2qm74	3389	19	(	(	-LRB-
cord-015021-pol2qm74	3389	20	assessed	assess	VBN
cord-015021-pol2qm74	3389	21	by	by	IN
cord-015021-pol2qm74	3389	22	FACS	FACS	NNP
cord-015021-pol2qm74	3389	23	analysis	analysis	NN
cord-015021-pol2qm74	3389	24	with	with	IN
cord-015021-pol2qm74	3389	25	the	the	DT
cord-015021-pol2qm74	3389	26	anti	anti	JJ
cord-015021-pol2qm74	3389	27	-	-	JJ
cord-015021-pol2qm74	3389	28	mouse	mouse	JJ
cord-015021-pol2qm74	3389	29	c	c	NNP
cord-015021-pol2qm74	3389	30	-	-	HYPH
cord-015021-pol2qm74	3389	31	kit	kit	NN
cord-015021-pol2qm74	3389	32	antibody	antibody	NN
cord-015021-pol2qm74	3389	33	ACK-2	ACK-2	NNP
cord-015021-pol2qm74	3389	34	)	)	-RRB-
cord-015021-pol2qm74	3389	35	nor	nor	CC
cord-015021-pol2qm74	3389	36	KL	kl	NN
cord-015021-pol2qm74	3389	37	-	-	HYPH
cord-015021-pol2qm74	3389	38	mediated	mediate	VBN
cord-015021-pol2qm74	3389	39	proliferation	proliferation	NN
cord-015021-pol2qm74	3389	40	or	or	CC
cord-015021-pol2qm74	3389	41	chemotaxis	chemotaxis	NN
cord-015021-pol2qm74	3389	42	.	.	.
cord-015021-pol2qm74	3390	1	In	in	IN
cord-015021-pol2qm74	3390	2	contrast	contrast	NN
cord-015021-pol2qm74	3390	3	,	,	,
cord-015021-pol2qm74	3390	4	IL-4	IL-4	NNP
cord-015021-pol2qm74	3390	5	syeergistically	syeergistically	RB
cord-015021-pol2qm74	3390	6	increased	increase	VBD
cord-015021-pol2qm74	3390	7	KL	KL	NNP
cord-015021-pol2qm74	3390	8	-	-	HYPH
cord-015021-pol2qm74	3390	9	stimulated	stimulate	VBN
cord-015021-pol2qm74	3390	10	growth	growth	NN
cord-015021-pol2qm74	3390	11	of	of	IN
cord-015021-pol2qm74	3390	12	BMMC	BMMC	NNP
cord-015021-pol2qm74	3390	13	in	in	IN
cord-015021-pol2qm74	3390	14	a	a	DT
cord-015021-pol2qm74	3390	15	short	short	JJ
cord-015021-pol2qm74	3390	16	-	-	HYPH
cord-015021-pol2qm74	3390	17	term	term	NN
cord-015021-pol2qm74	3390	18	proliferation	proliferation	NN
cord-015021-pol2qm74	3390	19	assay	assay	NN
cord-015021-pol2qm74	3390	20	(	(	-LRB-
cord-015021-pol2qm74	3390	21	MTT	MTT	NNP
cord-015021-pol2qm74	3390	22	-	-	HYPH
cord-015021-pol2qm74	3390	23	tes0	tes0	NN
cord-015021-pol2qm74	3390	24	.	.	.
cord-015021-pol2qm74	3391	1	Pre	pre	JJ
cord-015021-pol2qm74	3391	2	-	-	NN
cord-015021-pol2qm74	3391	3	incubation	incubation	NN
cord-015021-pol2qm74	3391	4	of	of	IN
cord-015021-pol2qm74	3391	5	BMMC	BMMC	NNP
cord-015021-pol2qm74	3391	6	with	with	IN
cord-015021-pol2qm74	3391	7	rhuTGFl~	rhuTGFl~	NNS
cord-015021-pol2qm74	3391	8	1	1	CD
cord-015021-pol2qm74	3391	9	(	(	-LRB-
cord-015021-pol2qm74	3391	10	5.0	5.0	CD
cord-015021-pol2qm74	3391	11	,	,	,
cord-015021-pol2qm74	3391	12	1.0	1.0	CD
cord-015021-pol2qm74	3391	13	,	,	,
cord-015021-pol2qm74	3391	14	or	or	CC
cord-015021-pol2qm74	3391	15	0.1	0.1	CD
cord-015021-pol2qm74	3391	16	ng	ng	NN
cord-015021-pol2qm74	3391	17	/	/	SYM
cord-015021-pol2qm74	3391	18	ml	ml	NN
cord-015021-pol2qm74	3391	19	)	)	-RRB-
cord-015021-pol2qm74	3391	20	for	for	IN
cord-015021-pol2qm74	3391	21	24h	24h	NNS
cord-015021-pol2qm74	3391	22	had	have	VBD
cord-015021-pol2qm74	3391	23	no	no	DT
cord-015021-pol2qm74	3391	24	effect	effect	NN
cord-015021-pol2qm74	3391	25	on	on	IN
cord-015021-pol2qm74	3391	26	kit	kit	NN
cord-015021-pol2qm74	3391	27	receptor	receptor	NN
cord-015021-pol2qm74	3391	28	expression	expression	NN
cord-015021-pol2qm74	3391	29	,	,	,
cord-015021-pol2qm74	3391	30	although	although	IN
cord-015021-pol2qm74	3391	31	TGFfil	TGFfil	NNP
cord-015021-pol2qm74	3391	32	at	at	IN
cord-015021-pol2qm74	3391	33	concentrations	concentration	NNS
cord-015021-pol2qm74	3391	34	of	of	IN
cord-015021-pol2qm74	3391	35	0.5	0.5	CD
cord-015021-pol2qm74	3391	36	-5.0	-5.0	CD
cord-015021-pol2qm74	3391	37	ng	ng	NN
cord-015021-pol2qm74	3391	38	/	/	SYM
cord-015021-pol2qm74	3391	39	ml	ml	XX
cord-015021-pol2qm74	3391	40	completely	completely	RB
cord-015021-pol2qm74	3391	41	suppressed	suppress	VBD
cord-015021-pol2qm74	3391	42	the	the	DT
cord-015021-pol2qm74	3391	43	proliferative	proliferative	JJ
cord-015021-pol2qm74	3391	44	action	action	NN
cord-015021-pol2qm74	3391	45	of	of	IN
cord-015021-pol2qm74	3391	46	KL	KL	NNP
cord-015021-pol2qm74	3391	47	on	on	IN
cord-015021-pol2qm74	3391	48	these	these	DT
cord-015021-pol2qm74	3391	49	ceils	ceil	NNS
cord-015021-pol2qm74	3391	50	.	.	.
cord-015021-pol2qm74	3392	1	Similar	similar	JJ
cord-015021-pol2qm74	3392	2	anti	anti	JJ
cord-015021-pol2qm74	3392	3	-	-	JJ
cord-015021-pol2qm74	3392	4	proliferative	proliferative	JJ
cord-015021-pol2qm74	3392	5	effects	effect	NNS
cord-015021-pol2qm74	3392	6	of	of	IN
cord-015021-pol2qm74	3392	7	TGFg	TGFg	NNS
cord-015021-pol2qm74	3392	8	1	1	CD
cord-015021-pol2qm74	3392	9	were	be	VBD
cord-015021-pol2qm74	3392	10	observed	observe	VBN
cord-015021-pol2qm74	3392	11	in	in	IN
cord-015021-pol2qm74	3392	12	various	various	JJ
cord-015021-pol2qm74	3392	13	factor	factor	NN
cord-015021-pol2qm74	3392	14	-	-	HYPH
cord-015021-pol2qm74	3392	15	dependent	dependent	JJ
cord-015021-pol2qm74	3392	16	mast	mast	JJ
cord-015021-pol2qm74	3392	17	cell	cell	NN
cord-015021-pol2qm74	3392	18	lines	line	NNS
cord-015021-pol2qm74	3392	19	stimulated	stimulate	VBN
cord-015021-pol2qm74	3392	20	with	with	IN
cord-015021-pol2qm74	3392	21	different	different	JJ
cord-015021-pol2qm74	3392	22	mast	mast	JJ
cord-015021-pol2qm74	3392	23	cell	cell	NN
cord-015021-pol2qm74	3392	24	growth	growth	NN
cord-015021-pol2qm74	3392	25	factors	factor	NNS
cord-015021-pol2qm74	3392	26	(	(	-LRB-
cord-015021-pol2qm74	3392	27	IL-3	IL-3	NNP
cord-015021-pol2qm74	3392	28	,	,	,
cord-015021-pol2qm74	3392	29	1I,-4	1i,-4	CD
cord-015021-pol2qm74	3392	30	,	,	,
cord-015021-pol2qm74	3392	31	IL-9	IL-9	NNP
cord-015021-pol2qm74	3392	32	,	,	,
cord-015021-pol2qm74	3392	33	and/or	and/or	CC
cord-015021-pol2qm74	3392	34	IL-10	IL-10	NNP
cord-015021-pol2qm74	3392	35	)	)	-RRB-
cord-015021-pol2qm74	3392	36	.	.	.
cord-015021-pol2qm74	3393	1	Moreover	moreover	RB
cord-015021-pol2qm74	3393	2	,	,	,
cord-015021-pol2qm74	3393	3	pre	pre	JJ
cord-015021-pol2qm74	3393	4	-	-	JJ
cord-015021-pol2qm74	3393	5	incuhation	incuhation	JJ
cord-015021-pol2qm74	3393	6	(	(	-LRB-
cord-015021-pol2qm74	3393	7	24h	24h	NNS
cord-015021-pol2qm74	3393	8	)	)	-RRB-
cord-015021-pol2qm74	3393	9	of	of	IN
cord-015021-pol2qm74	3393	10	BMMC	BMMC	NNP
cord-015021-pol2qm74	3393	11	with	with	IN
cord-015021-pol2qm74	3393	12	TGF	TGF	NNP
cord-015021-pol2qm74	3393	13	-	-	HYPH
cord-015021-pol2qm74	3393	14	gl	gl	NNP
cord-015021-pol2qm74	3393	15	(	(	-LRB-
cord-015021-pol2qm74	3393	16	>	>	NFP
cord-015021-pol2qm74	3393	17	500	500	CD
cord-015021-pol2qm74	3393	18	pg	pg	NN
cord-015021-pol2qm74	3393	19	/	/	SYM
cord-015021-pol2qm74	3393	20	ml	ml	NN
cord-015021-pol2qm74	3393	21	)	)	-RRB-
cord-015021-pol2qm74	3393	22	significantly	significantly	RB
cord-015021-pol2qm74	3393	23	enhanced	enhance	VBD
cord-015021-pol2qm74	3393	24	spontaneous	spontaneous	JJ
cord-015021-pol2qm74	3393	25	undirected	undirected	JJ
cord-015021-pol2qm74	3393	26	cell	cell	NN
cord-015021-pol2qm74	3393	27	movement	movement	NN
cord-015021-pol2qm74	3393	28	(	(	-LRB-
cord-015021-pol2qm74	3393	29	chemokinesis	chemokinesis	NNP
cord-015021-pol2qm74	3393	30	)	)	-RRB-
cord-015021-pol2qm74	3393	31	and	and	CC
cord-015021-pol2qm74	3393	32	synergistically	synergistically	RB
cord-015021-pol2qm74	3393	33	increased	increase	VBD
cord-015021-pol2qm74	3393	34	IL-3-or	IL-3-or	NNP
cord-015021-pol2qm74	3393	35	KL	KL	NNP
cord-015021-pol2qm74	3393	36	-	-	HYPH
cord-015021-pol2qm74	3393	37	induced	induce	VBN
cord-015021-pol2qm74	3393	38	chemetaxis	chemetaxis	NNP
cord-015021-pol2qm74	3393	39	.	.	.
cord-015021-pol2qm74	3394	1	When	when	WRB
cord-015021-pol2qm74	3394	2	BMMC	BMMC	NNP
cord-015021-pol2qm74	3394	3	were	be	VBD
cord-015021-pol2qm74	3394	4	preAncuhated	preancuhate	VBN
cord-015021-pol2qm74	3394	5	with	with	IN
cord-015021-pol2qm74	3394	6	rmuKL	rmuKL	NNP
cord-015021-pol2qm74	3394	7	(	(	-LRB-
cord-015021-pol2qm74	3394	8	200	200	CD
cord-015021-pol2qm74	3394	9	ng	ng	NN
cord-015021-pol2qm74	3394	10	/	/	SYM
cord-015021-pol2qm74	3394	11	ml	ml	NN
cord-015021-pol2qm74	3394	12	)	)	-RRB-
cord-015021-pol2qm74	3394	13	for	for	IN
cord-015021-pol2qm74	3394	14	1	1	CD
cord-015021-pol2qm74	3394	15	,	,	,
cord-015021-pol2qm74	3394	16	3	3	CD
cord-015021-pol2qm74	3394	17	.	.	NN
cord-015021-pol2qm74	3394	18	or	or	CC
cord-015021-pol2qm74	3394	19	5	5	CD
cord-015021-pol2qm74	3394	20	days	day	NNS
cord-015021-pol2qm74	3394	21	,	,	,
cord-015021-pol2qm74	3394	22	a	a	DT
cord-015021-pol2qm74	3394	23	transient	transient	JJ
cord-015021-pol2qm74	3394	24	down	down	NN
cord-015021-pol2qm74	3394	25	-	-	HYPH
cord-015021-pol2qm74	3394	26	modulation	modulation	NN
cord-015021-pol2qm74	3394	27	of	of	IN
cord-015021-pol2qm74	3394	28	kit	kit	NN
cord-015021-pol2qm74	3394	29	receptors	receptor	NNS
cord-015021-pol2qm74	3394	30	with	with	IN
cord-015021-pol2qm74	3394	31	a	a	DT
cord-015021-pol2qm74	3394	32	maximum	maximum	JJ
cord-015021-pol2qm74	3394	33	effect	effect	NN
cord-015021-pol2qm74	3394	34	on	on	IN
cord-015021-pol2qm74	3394	35	day	day	NN
cord-015021-pol2qm74	3394	36	1	1	CD
cord-015021-pol2qm74	3394	37	was	be	VBD
cord-015021-pol2qm74	3394	38	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3394	39	by	by	IN
cord-015021-pol2qm74	3394	40	FACS	FACS	NNP
cord-015021-pol2qm74	3394	41	analysis	analysis	NN
cord-015021-pol2qm74	3394	42	and	and	CC
cord-015021-pol2qm74	3394	43	correlated	correlate	VBD
cord-015021-pol2qm74	3394	44	well	well	RB
cord-015021-pol2qm74	3394	45	with	with	IN
cord-015021-pol2qm74	3394	46	a	a	DT
cord-015021-pol2qm74	3394	47	decreased	decrease	VBN
cord-015021-pol2qm74	3394	48	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	3394	49	response	response	NN
cord-015021-pol2qm74	3394	50	of	of	IN
cord-015021-pol2qm74	3394	51	these	these	DT
cord-015021-pol2qm74	3394	52	cells	cell	NNS
cord-015021-pol2qm74	3394	53	.	.	.
cord-015021-pol2qm74	3395	1	In	in	IN
cord-015021-pol2qm74	3395	2	conclusion	conclusion	NN
cord-015021-pol2qm74	3395	3	our	-PRON-	PRP$
cord-015021-pol2qm74	3395	4	results	result	NNS
cord-015021-pol2qm74	3395	5	show	show	VBP
cord-015021-pol2qm74	3395	6	that	that	IN
cord-015021-pol2qm74	3395	7	neither	neither	CC
cord-015021-pol2qm74	3395	8	IL-4	IL-4	NNP
cord-015021-pol2qm74	3395	9	nor	nor	CC
cord-015021-pol2qm74	3395	10	TGFI31	TGFI31	NNP
cord-015021-pol2qm74	3395	11	affect	affect	VB
cord-015021-pol2qm74	3395	12	expression	expression	NN
cord-015021-pol2qm74	3395	13	of	of	IN
cord-015021-pol2qm74	3395	14	kit	kit	NN
cord-015021-pol2qm74	3395	15	receptors	receptor	NNS
cord-015021-pol2qm74	3395	16	in	in	IN
cord-015021-pol2qm74	3395	17	primary	primary	JJ
cord-015021-pol2qm74	3395	18	murine	murine	JJ
cord-015021-pol2qm74	3395	19	BMMC	BMMC	NNP
cord-015021-pol2qm74	3395	20	.	.	.
cord-015021-pol2qm74	3396	1	It	-PRON-	PRP
cord-015021-pol2qm74	3396	2	is	be	VBZ
cord-015021-pol2qm74	3396	3	reasonable	reasonable	JJ
cord-015021-pol2qm74	3396	4	to	to	TO
cord-015021-pol2qm74	3396	5	suggest	suggest	VB
cord-015021-pol2qm74	3396	6	that	that	IN
cord-015021-pol2qm74	3396	7	c	c	NN
cord-015021-pol2qm74	3396	8	-	-	HYPH
cord-015021-pol2qm74	3396	9	kit	kit	NN
cord-015021-pol2qm74	3396	10	expression	expression	NN
cord-015021-pol2qm74	3396	11	is	be	VBZ
cord-015021-pol2qm74	3396	12	controlled	control	VBN
cord-015021-pol2qm74	3396	13	in	in	IN
cord-015021-pol2qm74	3396	14	a	a	DT
cord-015021-pol2qm74	3396	15	cell	cell	NN
cord-015021-pol2qm74	3396	16	type	type	NN
cord-015021-pol2qm74	3396	17	-	-	HYPH
cord-015021-pol2qm74	3396	18	specific	specific	JJ
cord-015021-pol2qm74	3396	19	manner	manner	NN
cord-015021-pol2qm74	3396	20	.	.	.
cord-015021-pol2qm74	3397	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	3397	2	,	,	,
cord-015021-pol2qm74	3397	3	TGFgl	TGFgl	NNP
cord-015021-pol2qm74	3397	4	is	be	VBZ
cord-015021-pol2qm74	3397	5	obviously	obviously	RB
cord-015021-pol2qm74	3397	6	able	able	JJ
cord-015021-pol2qm74	3397	7	to	to	TO
cord-015021-pol2qm74	3397	8	dissect	dissect	VB
cord-015021-pol2qm74	3397	9	the	the	DT
cord-015021-pol2qm74	3397	10	proliferative	proliferative	NN
cord-015021-pol2qm74	3397	11	from	from	IN
cord-015021-pol2qm74	3397	12	the	the	DT
cord-015021-pol2qm74	3397	13	migrational	migrational	JJ
cord-015021-pol2qm74	3397	14	signal	signal	NN
cord-015021-pol2qm74	3397	15	transducted	transducte	VBN
cord-015021-pol2qm74	3397	16	by	by	IN
cord-015021-pol2qm74	3397	17	KL	KL	NNP
cord-015021-pol2qm74	3397	18	in	in	IN
cord-015021-pol2qm74	3397	19	these	these	DT
cord-015021-pol2qm74	3397	20	cells	cell	NNS
cord-015021-pol2qm74	3397	21	.	.	.
cord-015021-pol2qm74	3398	1	Objectives	objective	NNS
cord-015021-pol2qm74	3398	2	of	of	IN
cord-015021-pol2qm74	3398	3	the	the	DT
cord-015021-pol2qm74	3398	4	study	study	NN
cord-015021-pol2qm74	3398	5	:	:	:
cord-015021-pol2qm74	3398	6	Antisense	Antisense	NNP
cord-015021-pol2qm74	3398	7	strategies	strategy	NNS
cord-015021-pol2qm74	3398	8	using	use	VBG
cord-015021-pol2qm74	3398	9	DNA	dna	NN
cord-015021-pol2qm74	3398	10	-	-	HYPH
cord-015021-pol2qm74	3398	11	otigonucleofides	otigonucleofide	NNS
cord-015021-pol2qm74	3398	12	(	(	-LRB-
cord-015021-pol2qm74	3398	13	ODN	ODN	NNP
cord-015021-pol2qm74	3398	14	)	)	-RRB-
cord-015021-pol2qm74	3398	15	to	to	TO
cord-015021-pol2qm74	3398	16	modulate	modulate	VB
cord-015021-pol2qm74	3398	17	the	the	DT
cord-015021-pol2qm74	3398	18	cytokine	cytokine	NN
cord-015021-pol2qm74	3398	19	response	response	NN
cord-015021-pol2qm74	3398	20	are	be	VBP
cord-015021-pol2qm74	3398	21	presently	presently	RB
cord-015021-pol2qm74	3398	22	under	under	IN
cord-015021-pol2qm74	3398	23	investigation	investigation	NN
cord-015021-pol2qm74	3398	24	.	.	.
cord-015021-pol2qm74	3399	1	ODN	ODN	NNP
cord-015021-pol2qm74	3399	2	are	be	VBP
cord-015021-pol2qm74	3399	3	thought	think	VBN
cord-015021-pol2qm74	3399	4	to	to	TO
cord-015021-pol2qm74	3399	5	act	act	VB
cord-015021-pol2qm74	3399	6	very	very	RB
cord-015021-pol2qm74	3399	7	specifically	specifically	RB
cord-015021-pol2qm74	3399	8	with	with	IN
cord-015021-pol2qm74	3399	9	little	little	JJ
cord-015021-pol2qm74	3399	10	or	or	CC
cord-015021-pol2qm74	3399	11	no	no	DT
cord-015021-pol2qm74	3399	12	relevant	relevant	JJ
cord-015021-pol2qm74	3399	13	negative	negative	JJ
cord-015021-pol2qm74	3399	14	side	side	NN
cord-015021-pol2qm74	3399	15	effects	effect	NNS
cord-015021-pol2qm74	3399	16	.	.	.
cord-015021-pol2qm74	3400	1	We	-PRON-	PRP
cord-015021-pol2qm74	3400	2	now	now	RB
cord-015021-pol2qm74	3400	3	report	report	VBP
cord-015021-pol2qm74	3400	4	that	that	IN
cord-015021-pol2qm74	3400	5	ODN	ODN	NNP
cord-015021-pol2qm74	3400	6	unspeeifically	unspeeifically	RB
cord-015021-pol2qm74	3400	7	protect	protect	VB
cord-015021-pol2qm74	3400	8	WEHI	WEHI	NNP
cord-015021-pol2qm74	3400	9	164	164	CD
cord-015021-pol2qm74	3400	10	cells	cell	NNS
cord-015021-pol2qm74	3400	11	from	from	IN
cord-015021-pol2qm74	3400	12	TNF	TNF	NNP
cord-015021-pol2qm74	3400	13	-	-	HYPH
cord-015021-pol2qm74	3400	14	mediated	mediate	VBN
cord-015021-pol2qm74	3400	15	cytolysis	cytolysis	NN
cord-015021-pol2qm74	3400	16	.	.	.
cord-015021-pol2qm74	3401	1	Material	material	NN
cord-015021-pol2qm74	3401	2	and	and	CC
cord-015021-pol2qm74	3401	3	Methods	method	NNS
cord-015021-pol2qm74	3401	4	:	:	:
cord-015021-pol2qm74	3401	5	WEHI	WEHI	NNP
cord-015021-pol2qm74	3401	6	164	164	CD
cord-015021-pol2qm74	3401	7	subclone	subclone	VBD
cord-015021-pol2qm74	3401	8	13	13	CD
cord-015021-pol2qm74	3401	9	ceils	ceil	NNS
cord-015021-pol2qm74	3401	10	(	(	-LRB-
cord-015021-pol2qm74	3401	11	5	5	CD
cord-015021-pol2qm74	3401	12	x	x	SYM
cord-015021-pol2qm74	3401	13	105	105	CD
cord-015021-pol2qm74	3401	14	)	)	-RRB-
cord-015021-pol2qm74	3402	1	,	,	,
cord-015021-pol2qm74	3402	2	that	that	WDT
cord-015021-pol2qm74	3402	3	are	be	VBP
cord-015021-pol2qm74	3402	4	highly	highly	RB
cord-015021-pol2qm74	3402	5	sensitive	sensitive	JJ
cord-015021-pol2qm74	3402	6	to	to	IN
cord-015021-pol2qm74	3402	7	the	the	DT
cord-015021-pol2qm74	3402	8	cytolytic	cytolytic	JJ
cord-015021-pol2qm74	3402	9	activity	activity	NN
cord-015021-pol2qm74	3402	10	of	of	IN
cord-015021-pol2qm74	3402	11	TNF	TNF	NNP
cord-015021-pol2qm74	3402	12	,	,	,
cord-015021-pol2qm74	3402	13	were	be	VBD
cord-015021-pol2qm74	3402	14	grown	grow	VBN
cord-015021-pol2qm74	3402	15	on	on	IN
cord-015021-pol2qm74	3402	16	96-well	96-well	CD
cord-015021-pol2qm74	3402	17	culture	culture	NN
cord-015021-pol2qm74	3402	18	plates	plate	NNS
cord-015021-pol2qm74	3402	19	in	in	IN
cord-015021-pol2qm74	3402	20	RPM11640	RPM11640	NNP
cord-015021-pol2qm74	3402	21	medium	medium	NN
cord-015021-pol2qm74	3402	22	.	.	.
cord-015021-pol2qm74	3403	1	After	after	IN
cord-015021-pol2qm74	3403	2	24	24	CD
cord-015021-pol2qm74	3403	3	hours	hour	NNS
cord-015021-pol2qm74	3403	4	,	,	,
cord-015021-pol2qm74	3403	5	phosphorothioate(PS)and	phosphorothioate(ps)and	NN
cord-015021-pol2qm74	3403	6	partially	partially	RB
cord-015021-pol2qm74	3403	7	PS	ps	NN
cord-015021-pol2qm74	3403	8	-	-	HYPH
cord-015021-pol2qm74	3403	9	modified	modify	VBN
cord-015021-pol2qm74	3403	10	-	-	HYPH
cord-015021-pol2qm74	3403	11	ODN	odn	NN
cord-015021-pol2qm74	3403	12	as	as	RB
cord-015021-pol2qm74	3403	13	well	well	RB
cord-015021-pol2qm74	3403	14	as	as	IN
cord-015021-pol2qm74	3403	15	phesphodiester	phesphodiester	JJ
cord-015021-pol2qm74	3403	16	-	-	HYPH
cord-015021-pol2qm74	3403	17	ODN	ODN	NNP
cord-015021-pol2qm74	3403	18	(	(	-LRB-
cord-015021-pol2qm74	3403	19	20	20	CD
cord-015021-pol2qm74	3403	20	-	-	HYPH
cord-015021-pol2qm74	3403	21	29bp	29bp	CD
cord-015021-pol2qm74	3403	22	)	)	-RRB-
cord-015021-pol2qm74	3403	23	were	be	VBD
cord-015021-pol2qm74	3403	24	added	add	VBN
cord-015021-pol2qm74	3403	25	(	(	-LRB-
cord-015021-pol2qm74	3403	26	0.1	0.1	CD
cord-015021-pol2qm74	3403	27	,	,	,
cord-015021-pol2qm74	3403	28	1	1	CD
cord-015021-pol2qm74	3403	29	and	and	CC
cord-015021-pol2qm74	3403	30	10	10	CD
cord-015021-pol2qm74	3403	31	pM	pm	NN
cord-015021-pol2qm74	3403	32	)	)	-RRB-
cord-015021-pol2qm74	3403	33	.	.	.
cord-015021-pol2qm74	3404	1	Four	four	CD
cord-015021-pol2qm74	3404	2	hours	hour	NNS
cord-015021-pol2qm74	3404	3	after	after	IN
cord-015021-pol2qm74	3404	4	incubation	incubation	NN
cord-015021-pol2qm74	3404	5	with	with	IN
cord-015021-pol2qm74	3404	6	ODN	ODN	NNP
cord-015021-pol2qm74	3404	7	,	,	,
cord-015021-pol2qm74	3404	8	ce(I	ce(i	NN
cord-015021-pol2qm74	3404	9	lysis	lysis	NN
cord-015021-pol2qm74	3404	10	was	be	VBD
cord-015021-pol2qm74	3404	11	induced	induce	VBN
cord-015021-pol2qm74	3404	12	by	by	IN
cord-015021-pol2qm74	3404	13	recombinant	recombinant	JJ
cord-015021-pol2qm74	3404	14	murina	murina	NNP
cord-015021-pol2qm74	3404	15	TNF	TNF	NNP
cord-015021-pol2qm74	3404	16	.	.	.
cord-015021-pol2qm74	3405	1	After	after	IN
cord-015021-pol2qm74	3405	2	18	18	CD
cord-015021-pol2qm74	3405	3	hours	hour	NNS
cord-015021-pol2qm74	3405	4	the	the	DT
cord-015021-pol2qm74	3405	5	plates	plate	NNS
cord-015021-pol2qm74	3405	6	were	be	VBD
cord-015021-pol2qm74	3405	7	washed	wash	VBN
cord-015021-pol2qm74	3405	8	and	and	CC
cord-015021-pol2qm74	3405	9	stained	stain	VBN
cord-015021-pol2qm74	3405	10	with	with	IN
cord-015021-pol2qm74	3405	11	crystal	crystal	JJ
cord-015021-pol2qm74	3405	12	violet	violet	NN
cord-015021-pol2qm74	3405	13	Cell	Cell	NNP
cord-015021-pol2qm74	3405	14	lysis	lysis	NN
cord-015021-pol2qm74	3405	15	was	be	VBD
cord-015021-pol2qm74	3405	16	determined	determine	VBN
cord-015021-pol2qm74	3405	17	by	by	IN
cord-015021-pol2qm74	3405	18	reading	read	VBG
cord-015021-pol2qm74	3405	19	the	the	DT
cord-015021-pol2qm74	3405	20	absorbance	absorbance	NN
cord-015021-pol2qm74	3405	21	(	(	-LRB-
cord-015021-pol2qm74	3405	22	ABS	abs	NN
cord-015021-pol2qm74	3405	23	)	)	-RRB-
cord-015021-pol2qm74	3405	24	at	at	IN
cord-015021-pol2qm74	3405	25	590	590	CD
cord-015021-pol2qm74	3405	26	nm	nm	NN
cord-015021-pol2qm74	3405	27	.	.	.
cord-015021-pol2qm74	3406	1	Results	result	NNS
cord-015021-pol2qm74	3406	2	:	:	:
cord-015021-pol2qm74	3407	1	WEHI	WEHI	NNP
cord-015021-pol2qm74	3407	2	164	164	CD
cord-015021-pol2qm74	3407	3	ceils	ceil	NNS
cord-015021-pol2qm74	3407	4	incubated	incubate	VBN
cord-015021-pol2qm74	3407	5	with	with	IN
cord-015021-pol2qm74	3407	6	TNF	TNF	NNP
cord-015021-pol2qm74	3407	7	(	(	-LRB-
cord-015021-pol2qm74	3407	8	1	1	CD
cord-015021-pol2qm74	3407	9	-	-	HYPH
cord-015021-pol2qm74	3407	10	8ng	8ng	NN
cord-015021-pol2qm74	3407	11	/	/	SYM
cord-015021-pol2qm74	3407	12	ml	ml	NN
cord-015021-pol2qm74	3407	13	)	)	-RRB-
cord-015021-pol2qm74	3407	14	were	be	VBD
cord-015021-pol2qm74	3407	15	completely	completely	RB
cord-015021-pol2qm74	3407	16	lysed	lyse	VBN
cord-015021-pol2qm74	3407	17	after	after	IN
cord-015021-pol2qm74	3407	18	18	18	CD
cord-015021-pol2qm74	3407	19	hours	hour	NNS
cord-015021-pol2qm74	3407	20	(	(	-LRB-
cord-015021-pol2qm74	3407	21	0	0	CD
cord-015021-pol2qm74	3407	22	%	%	NN
cord-015021-pol2qm74	3407	23	ABS	abs	NN
cord-015021-pol2qm74	3407	24	)	)	-RRB-
cord-015021-pol2qm74	3407	25	.	.	.
cord-015021-pol2qm74	3408	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	3408	2	,	,	,
cord-015021-pol2qm74	3408	3	WEHI	WEHI	NNP
cord-015021-pol2qm74	3408	4	cells	cell	NNS
cord-015021-pol2qm74	3408	5	incubated	incubate	VBN
cord-015021-pol2qm74	3408	6	with	with	IN
cord-015021-pol2qm74	3408	7	TNF	TNF	NNP
cord-015021-pol2qm74	3408	8	and	and	CC
cord-015021-pol2qm74	3408	9	ODN	ODN	NNP
cord-015021-pol2qm74	3408	10	resisted	resist	VBD
cord-015021-pol2qm74	3408	11	complete	complete	JJ
cord-015021-pol2qm74	3408	12	lysis	lysis	NN
cord-015021-pol2qm74	3408	13	,	,	,
cord-015021-pol2qm74	3408	14	eg	eg	IN
cord-015021-pol2qm74	3408	15	cells	cell	NNS
cord-015021-pol2qm74	3408	16	incubated	incubate	VBN
cord-015021-pol2qm74	3408	17	with	with	IN
cord-015021-pol2qm74	3408	18	2.5ng	2.5ng	CD
cord-015021-pol2qm74	3408	19	/	/	SYM
cord-015021-pol2qm74	3408	20	ml	ml	NN
cord-015021-pol2qm74	3408	21	TNF	TNF	NNP
cord-015021-pol2qm74	3408	22	and	and	CC
cord-015021-pol2qm74	3408	23	11JM	11jm	CD
cord-015021-pol2qm74	3408	24	ODN	ODN	NNP
cord-015021-pol2qm74	3408	25	showed	show	VBD
cord-015021-pol2qm74	3408	26	still	still	RB
cord-015021-pol2qm74	3408	27	30	30	CD
cord-015021-pol2qm74	3408	28	%	%	NN
cord-015021-pol2qm74	3408	29	of	of	IN
cord-015021-pol2qm74	3408	30	the	the	DT
cord-015021-pol2qm74	3408	31	absorbance	absorbance	NN
cord-015021-pol2qm74	3408	32	observed	observe	VBN
cord-015021-pol2qm74	3408	33	in	in	IN
cord-015021-pol2qm74	3408	34	control	control	NN
cord-015021-pol2qm74	3408	35	ceils	ceil	NNS
cord-015021-pol2qm74	3408	36	without	without	IN
cord-015021-pol2qm74	3408	37	TNF	TNF	NNP
cord-015021-pol2qm74	3408	38	(	(	-LRB-
cord-015021-pol2qm74	3408	39	100	100	CD
cord-015021-pol2qm74	3408	40	%	%	NN
cord-015021-pol2qm74	3408	41	ABS	abs	NN
cord-015021-pol2qm74	3408	42	)	)	-RRB-
cord-015021-pol2qm74	3408	43	.	.	.
cord-015021-pol2qm74	3409	1	The	the	DT
cord-015021-pol2qm74	3409	2	protective	protective	JJ
cord-015021-pol2qm74	3409	3	effect	effect	NN
cord-015021-pol2qm74	3409	4	of	of	IN
cord-015021-pol2qm74	3409	5	ODN	ODN	NNP
cord-015021-pol2qm74	3409	6	started	start	VBD
cord-015021-pol2qm74	3409	7	at	at	IN
cord-015021-pol2qm74	3409	8	0.1pM	0.1pm	CD
cord-015021-pol2qm74	3409	9	,	,	,
cord-015021-pol2qm74	3409	10	reached	reach	VBD
cord-015021-pol2qm74	3409	11	a	a	DT
cord-015021-pol2qm74	3409	12	maximum	maximum	NN
cord-015021-pol2qm74	3409	13	at	at	IN
cord-015021-pol2qm74	3409	14	1,uM	1,um	CD
cord-015021-pol2qm74	3409	15	,	,	,
cord-015021-pol2qm74	3409	16	and	and	CC
cord-015021-pol2qm74	3409	17	diminished	diminish	VBD
cord-015021-pol2qm74	3409	18	at	at	IN
cord-015021-pol2qm74	3409	19	101JM	101JM	NNP
cord-015021-pol2qm74	3409	20	.	.	.
cord-015021-pol2qm74	3410	1	With	with	IN
cord-015021-pol2qm74	3410	2	increasing	increase	VBG
cord-015021-pol2qm74	3410	3	amounts	amount	NNS
cord-015021-pol2qm74	3410	4	of	of	IN
cord-015021-pol2qm74	3410	5	TNF	TNF	NNP
cord-015021-pol2qm74	3410	6	the	the	DT
cord-015021-pol2qm74	3410	7	protective	protective	JJ
cord-015021-pol2qm74	3410	8	effect	effect	NN
cord-015021-pol2qm74	3410	9	of	of	IN
cord-015021-pol2qm74	3410	10	QDN	QDN	NNP
cord-015021-pol2qm74	3410	11	decreased	decrease	VBD
cord-015021-pol2qm74	3410	12	and	and	CC
cord-015021-pol2qm74	3410	13	no	no	DT
cord-015021-pol2qm74	3410	14	protection	protection	NN
cord-015021-pol2qm74	3410	15	was	be	VBD
cord-015021-pol2qm74	3410	16	detectable	detectable	JJ
cord-015021-pol2qm74	3410	17	at	at	IN
cord-015021-pol2qm74	3410	18	8ng	8ng	NNP
cord-015021-pol2qm74	3410	19	TNF	TNF	NNP
cord-015021-pol2qm74	3410	20	per	per	IN
cord-015021-pol2qm74	3410	21	ml	ml	NNP
cord-015021-pol2qm74	3410	22	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3410	23	:	:	:
cord-015021-pol2qm74	3411	1	DNA	dna	NN
cord-015021-pol2qm74	3411	2	-	-	HYPH
cord-015021-pol2qm74	3411	3	oligonucleotides	oligonucleotide	NNS
cord-015021-pol2qm74	3411	4	were	be	VBD
cord-015021-pol2qm74	3411	5	found	find	VBN
cord-015021-pol2qm74	3411	6	to	to	TO
cord-015021-pol2qm74	3411	7	unspecifically	unspecifically	RB
cord-015021-pol2qm74	3411	8	inhibit	inhibit	VB
cord-015021-pol2qm74	3411	9	TNF	TNF	NNP
cord-015021-pol2qm74	3411	10	-	-	HYPH
cord-015021-pol2qm74	3411	11	induced	induce	VBN
cord-015021-pol2qm74	3411	12	cytolysis	cytolysis	NNP
cord-015021-pol2qm74	3411	13	.	.	.
cord-015021-pol2qm74	3412	1	We	-PRON-	PRP
cord-015021-pol2qm74	3412	2	hypothesize	hypothesize	VBP
cord-015021-pol2qm74	3412	3	,	,	,
cord-015021-pol2qm74	3412	4	that	that	IN
cord-015021-pol2qm74	3412	5	this	this	DT
cord-015021-pol2qm74	3412	6	protective	protective	JJ
cord-015021-pol2qm74	3412	7	effect	effect	NN
cord-015021-pol2qm74	3412	8	of	of	IN
cord-015021-pol2qm74	3412	9	QDN	QDN	NNP
cord-015021-pol2qm74	3412	10	results	result	VBZ
cord-015021-pol2qm74	3412	11	from	from	IN
cord-015021-pol2qm74	3412	12	an	an	DT
cord-015021-pol2qm74	3412	13	inhibition	inhibition	NN
cord-015021-pol2qm74	3412	14	of	of	IN
cord-015021-pol2qm74	3412	15	the	the	DT
cord-015021-pol2qm74	3412	16	binding	binding	NN
cord-015021-pol2qm74	3412	17	of	of	IN
cord-015021-pol2qm74	3412	18	TNF	TNF	NNP
cord-015021-pol2qm74	3412	19	to	to	IN
cord-015021-pol2qm74	3412	20	its	-PRON-	PRP$
cord-015021-pol2qm74	3412	21	receptor	receptor	NN
cord-015021-pol2qm74	3412	22	,	,	,
cord-015021-pol2qm74	3412	23	or	or	CC
cord-015021-pol2qm74	3412	24	from	from	IN
cord-015021-pol2qm74	3412	25	interference	interference	NN
cord-015021-pol2qm74	3412	26	of	of	IN
cord-015021-pol2qm74	3412	27	ODN	ODN	NNP
cord-015021-pol2qm74	3412	28	with	with	IN
cord-015021-pol2qm74	3412	29	the	the	DT
cord-015021-pol2qm74	3412	30	subsequent	subsequent	JJ
cord-015021-pol2qm74	3412	31	signal	signal	NN
cord-015021-pol2qm74	3412	32	transduction	transduction	NN
cord-015021-pol2qm74	3412	33	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3412	34	.	.	.
cord-015021-pol2qm74	3413	1	As	as	IN
cord-015021-pol2qm74	3413	2	a	a	DT
cord-015021-pol2qm74	3413	3	consequence	consequence	NN
cord-015021-pol2qm74	3413	4	,	,	,
cord-015021-pol2qm74	3413	5	to	to	TO
cord-015021-pol2qm74	3413	6	discriminate	discriminate	VB
cord-015021-pol2qm74	3413	7	the	the	DT
cord-015021-pol2qm74	3413	8	specific	specific	JJ
cord-015021-pol2qm74	3413	9	effect	effect	NN
cord-015021-pol2qm74	3413	10	of	of	IN
cord-015021-pol2qm74	3413	11	ODN	ODN	NNP
cord-015021-pol2qm74	3413	12	in	in	IN
cord-015021-pol2qm74	3413	13	biologic	biologic	JJ
cord-015021-pol2qm74	3413	14	systems	system	NNS
cord-015021-pol2qm74	3413	15	,	,	,
cord-015021-pol2qm74	3413	16	several	several	JJ
cord-015021-pol2qm74	3413	17	control	control	NN
cord-015021-pol2qm74	3413	18	ODN	ODN	NNP
cord-015021-pol2qm74	3413	19	should	should	MD
cord-015021-pol2qm74	3413	20	be	be	VB
cord-015021-pol2qm74	3413	21	used	use	VBN
cord-015021-pol2qm74	3413	22	.	.	.
cord-015021-pol2qm74	3414	1	Secondly	secondly	RB
cord-015021-pol2qm74	3414	2	,	,	,
cord-015021-pol2qm74	3414	3	whether	whether	IN
cord-015021-pol2qm74	3414	4	DNA	dna	NN
cord-015021-pol2qm74	3414	5	released	release	VBN
cord-015021-pol2qm74	3414	6	by	by	IN
cord-015021-pol2qm74	3414	7	degradation	degradation	NN
cord-015021-pol2qm74	3414	8	of	of	IN
cord-015021-pol2qm74	3414	9	tumor	tumor	NN
cord-015021-pol2qm74	3414	10	cells	cell	NNS
cord-015021-pol2qm74	3414	11	or	or	CC
cord-015021-pol2qm74	3414	12	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	3414	13	can	can	MD
cord-015021-pol2qm74	3414	14	significantly	significantly	RB
cord-015021-pol2qm74	3414	15	impair	impair	VB
cord-015021-pol2qm74	3414	16	tumor	tumor	NN
cord-015021-pol2qm74	3414	17	-	-	HYPH
cord-015021-pol2qm74	3414	18	and	and	CC
cord-015021-pol2qm74	3414	19	immune	immune	JJ
cord-015021-pol2qm74	3414	20	-	-	HYPH
cord-015021-pol2qm74	3414	21	defense	defense	NN
cord-015021-pol2qm74	3414	22	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3414	23	merits	merit	VBZ
cord-015021-pol2qm74	3414	24	further	further	JJ
cord-015021-pol2qm74	3414	25	investigation	investigation	NN
cord-015021-pol2qm74	3414	26	Dr.	Dr.	NNP
cord-015021-pol2qm74	3414	27	med	med	NNP
cord-015021-pol2qm74	3414	28	.	.	.
cord-015021-pol2qm74	3415	1	Michael	Michael	NNP
cord-015021-pol2qm74	3415	2	Meisner	Meisner	NNP
cord-015021-pol2qm74	3415	3	,	,	,
cord-015021-pol2qm74	3415	4	Institut	Institut	NNP
cord-015021-pol2qm74	3415	5	for	for	IN
cord-015021-pol2qm74	3415	6	Anaesthesiologie	Anaesthesiologie	NNP
cord-015021-pol2qm74	3415	7	der	der	NNP
cord-015021-pol2qm74	3415	8	Universitat	Universitat	NNP
cord-015021-pol2qm74	3415	9	Erlangen	Erlangen	NNP
cord-015021-pol2qm74	3415	10	-	-	HYPH
cord-015021-pol2qm74	3415	11	NQmberg	NQmberg	NNP
cord-015021-pol2qm74	3415	12	,	,	,
cord-015021-pol2qm74	3415	13	Krankenhausstral	Krankenhausstral	NNP
cord-015021-pol2qm74	3415	14	~	~	NFP
cord-015021-pol2qm74	3415	15	e	e	SYM
cord-015021-pol2qm74	3415	16	12	12	CD
cord-015021-pol2qm74	3415	17	,	,	,
cord-015021-pol2qm74	3415	18	D-91054	D-91054	NNP
cord-015021-pol2qm74	3415	19	Erlangen	Erlangen	NNP
cord-015021-pol2qm74	3415	20	.	.	.
cord-015021-pol2qm74	3416	1	In	in	IN
cord-015021-pol2qm74	3416	2	this	this	DT
cord-015021-pol2qm74	3416	3	study	study	NN
cord-015021-pol2qm74	3416	4	we	-PRON-	PRP
cord-015021-pol2qm74	3416	5	investigated	investigate	VBD
cord-015021-pol2qm74	3416	6	the	the	DT
cord-015021-pol2qm74	3416	7	involvement	involvement	NN
cord-015021-pol2qm74	3416	8	of	of	IN
cord-015021-pol2qm74	3416	9	serine	serine	JJ
cord-015021-pol2qm74	3416	10	protease	protease	NN
cord-015021-pol2qm74	3416	11	and	and	CC
cord-015021-pol2qm74	3416	12	free	free	JJ
cord-015021-pol2qm74	3416	13	radical	radical	JJ
cord-015021-pol2qm74	3416	14	generation	generation	NN
cord-015021-pol2qm74	3416	15	in	in	IN
cord-015021-pol2qm74	3416	16	the	the	DT
cord-015021-pol2qm74	3416	17	systemic	systemic	JJ
cord-015021-pol2qm74	3416	18	release	release	NN
cord-015021-pol2qm74	3416	19	of	of	IN
cord-015021-pol2qm74	3416	20	tumor	tumor	NN
cord-015021-pol2qm74	3416	21	necrosis	necrosis	NN
cord-015021-pol2qm74	3416	22	factor	factor	NN
cord-015021-pol2qm74	3416	23	-	-	HYPH
cord-015021-pol2qm74	3416	24	alpha	alpha	NN
cord-015021-pol2qm74	3416	25	(	(	-LRB-
cord-015021-pol2qm74	3416	26	TNF	TNF	NNP
cord-015021-pol2qm74	3416	27	)	)	-RRB-
cord-015021-pol2qm74	3416	28	and	and	CC
cord-015021-pol2qm74	3416	29	interieukin	interieukin	NNP
cord-015021-pol2qm74	3416	30	I(IL-1	I(IL-1	NNP
cord-015021-pol2qm74	3416	31	)	)	-RRB-
cord-015021-pol2qm74	3416	32	,	,	,
cord-015021-pol2qm74	3416	33	in	in	IN
cord-015021-pol2qm74	3416	34	the	the	DT
cord-015021-pol2qm74	3416	35	sepsis	sepsis	NN
cord-015021-pol2qm74	3416	36	model	model	NN
cord-015021-pol2qm74	3416	37	of	of	IN
cord-015021-pol2qm74	3416	38	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3416	39	(	(	-LRB-
cord-015021-pol2qm74	3416	40	LPS	LPS	NNP
cord-015021-pol2qm74	3416	41	,	,	,
cord-015021-pol2qm74	3416	42	5mg	5mg	NN
cord-015021-pol2qm74	3416	43	/	/	SYM
cord-015021-pol2qm74	3416	44	kg	kg	NNP
cord-015021-pol2qm74	3416	45	i.p	i.p	NNP
cord-015021-pol2qm74	3416	46	.	.	.
cord-015021-pol2qm74	3416	47	)	)	-RRB-
cord-015021-pol2qm74	3416	48	induced	induce	VBN
cord-015021-pol2qm74	3416	49	hepatitis	hepatitis	NN
cord-015021-pol2qm74	3416	50	in	in	IN
cord-015021-pol2qm74	3416	51	galactosamine	galactosamine	NNP
cord-015021-pol2qm74	3416	52	(	(	-LRB-
cord-015021-pol2qm74	3416	53	GAIN	GAIN	NNP
cord-015021-pol2qm74	3416	54	,	,	,
cord-015021-pol2qm74	3416	55	18rag	18rag	JJ
cord-015021-pol2qm74	3416	56	/	/	SYM
cord-015021-pol2qm74	3416	57	mouse	mouse	NN
cord-015021-pol2qm74	3416	58	,	,	,
cord-015021-pol2qm74	3416	59	i.p	i.p	NNP
cord-015021-pol2qm74	3416	60	.	.	NNP
cord-015021-pol2qm74	3416	61	)	)	-RRB-
cord-015021-pol2qm74	3417	1	sensitized	sensitized	JJ
cord-015021-pol2qm74	3417	2	mice	mouse	NNS
cord-015021-pol2qm74	3417	3	.	.	.
cord-015021-pol2qm74	3418	1	Treatment	treatment	NN
cord-015021-pol2qm74	3418	2	of	of	IN
cord-015021-pol2qm74	3418	3	GAIN	gain	NN
cord-015021-pol2qm74	3418	4	-	-	HYPH
cord-015021-pol2qm74	3418	5	sensitized	sensitize	VBN
cord-015021-pol2qm74	3418	6	mice	mouse	NNS
cord-015021-pol2qm74	3418	7	with	with	IN
cord-015021-pol2qm74	3418	8	LPS	lp	NNS
cord-015021-pol2qm74	3418	9	(	(	-LRB-
cord-015021-pol2qm74	3418	10	GAIN	gain	NN
cord-015021-pol2qm74	3418	11	/	/	SYM
cord-015021-pol2qm74	3418	12	LPS	LPS	NNP
cord-015021-pol2qm74	3418	13	)	)	-RRB-
cord-015021-pol2qm74	3418	14	led	lead	VBD
cord-015021-pol2qm74	3418	15	to	to	IN
cord-015021-pol2qm74	3418	16	dramatic	dramatic	JJ
cord-015021-pol2qm74	3418	17	increase	increase	NN
cord-015021-pol2qm74	3418	18	in	in	IN
cord-015021-pol2qm74	3418	19	serum	serum	NN
cord-015021-pol2qm74	3418	20	cytokine	cytokine	NN
cord-015021-pol2qm74	3418	21	(	(	-LRB-
cord-015021-pol2qm74	3418	22	TNF	TNF	NNP
cord-015021-pol2qm74	3418	23	and	and	CC
cord-015021-pol2qm74	3418	24	IL	IL	NNP
cord-015021-pol2qm74	3418	25	-	-	:
cord-015021-pol2qm74	3418	26	I	I	NNP
cord-015021-pol2qm74	3418	27	)	)	-RRB-
cord-015021-pol2qm74	3418	28	ievels	ievel	VBZ
cord-015021-pol2qm74	3418	29	and	and	CC
cord-015021-pol2qm74	3418	30	transaminase	transaminase	NN
cord-015021-pol2qm74	3418	31	activity	activity	NN
cord-015021-pol2qm74	3418	32	at	at	IN
cord-015021-pol2qm74	3418	33	3	3	CD
cord-015021-pol2qm74	3418	34	hr	hr	NN
cord-015021-pol2qm74	3418	35	and	and	CC
cord-015021-pol2qm74	3418	36	8	8	CD
cord-015021-pol2qm74	3418	37	hr	hr	NN
cord-015021-pol2qm74	3418	38	respectively	respectively	RB
cord-015021-pol2qm74	3418	39	.	.	.
cord-015021-pol2qm74	3419	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	3419	2	of	of	IN
cord-015021-pol2qm74	3419	3	serine	serine	JJ
cord-015021-pol2qm74	3419	4	protease	protease	NN
cord-015021-pol2qm74	3419	5	inhibitor	inhibitor	NN
cord-015021-pol2qm74	3419	6	,	,	,
cord-015021-pol2qm74	3419	7	c	c	NNP
cord-015021-pol2qm74	3419	8	~	~	NFP
cord-015021-pol2qm74	3419	9	jantitrypsin	jantitrypsin	NNP
cord-015021-pol2qm74	3419	10	(	(	-LRB-
cord-015021-pol2qm74	3419	11	a	a	DT
cord-015021-pol2qm74	3419	12	j	j	NNP
cord-015021-pol2qm74	3419	13	-	-	HYPH
cord-015021-pol2qm74	3419	14	AT	AT	NNP
cord-015021-pol2qm74	3419	15	,	,	,
cord-015021-pol2qm74	3419	16	50mg	50mg	NN
cord-015021-pol2qm74	3419	17	/	/	SYM
cord-015021-pol2qm74	3419	18	kg	kg	NNP
cord-015021-pol2qm74	3419	19	i.p	i.p	NNP
cord-015021-pol2qm74	3419	20	.	.	NNP
cord-015021-pol2qm74	3419	21	)	)	-RRB-
cord-015021-pol2qm74	3419	22	,	,	,
cord-015021-pol2qm74	3419	23	30	30	CD
cord-015021-pol2qm74	3419	24	rains	rain	NNS
cord-015021-pol2qm74	3419	25	prior	prior	RB
cord-015021-pol2qm74	3419	26	to	to	IN
cord-015021-pol2qm74	3419	27	GAIN	gain	VB
cord-015021-pol2qm74	3419	28	/	/	SYM
cord-015021-pol2qm74	3419	29	LPS	lps	NN
cord-015021-pol2qm74	3419	30	treatment	treatment	NN
cord-015021-pol2qm74	3419	31	,	,	,
cord-015021-pol2qm74	3419	32	fully	fully	RB
cord-015021-pol2qm74	3419	33	protected	protect	VBD
cord-015021-pol2qm74	3419	34	the	the	DT
cord-015021-pol2qm74	3419	35	animals	animal	NNS
cord-015021-pol2qm74	3419	36	against	against	IN
cord-015021-pol2qm74	3419	37	the	the	DT
cord-015021-pol2qm74	3419	38	hepatotoxic	hepatotoxic	JJ
cord-015021-pol2qm74	3419	39	challenge	challenge	NN
cord-015021-pol2qm74	3419	40	with	with	IN
cord-015021-pol2qm74	3419	41	significantly	significantly	RB
cord-015021-pol2qm74	3419	42	reduced	reduce	VBN
cord-015021-pol2qm74	3419	43	serum	serum	NN
cord-015021-pol2qm74	3419	44	TNF	TNF	NNP
cord-015021-pol2qm74	3419	45	and	and	CC
cord-015021-pol2qm74	3419	46	IL-1	IL-1	NNP
cord-015021-pol2qm74	3419	47	levels	level	NNS
cord-015021-pol2qm74	3419	48	.	.	.
cord-015021-pol2qm74	3420	1	In	in	IN
cord-015021-pol2qm74	3420	2	order	order	NN
cord-015021-pol2qm74	3420	3	to	to	TO
cord-015021-pol2qm74	3420	4	block	block	VB
cord-015021-pol2qm74	3420	5	and	and	CC
cord-015021-pol2qm74	3420	6	scavenge	scavenge	VB
cord-015021-pol2qm74	3420	7	superoxide	superoxide	NN
cord-015021-pol2qm74	3420	8	generation	generation	NN
cord-015021-pol2qm74	3420	9	,	,	,
cord-015021-pol2qm74	3420	10	the	the	DT
cord-015021-pol2qm74	3420	11	mice	mouse	NNS
cord-015021-pol2qm74	3420	12	were	be	VBD
cord-015021-pol2qm74	3420	13	pretreated	pretreate	VBN
cord-015021-pol2qm74	3420	14	with	with	IN
cord-015021-pol2qm74	3420	15	xanthine	xanthine	NN
cord-015021-pol2qm74	3420	16	oxidase	oxidase	NN
cord-015021-pol2qm74	3420	17	inhibitor	inhibitor	NN
cord-015021-pol2qm74	3420	18	,	,	,
cord-015021-pol2qm74	3420	19	allopurinol	allopurinol	NNP
cord-015021-pol2qm74	3420	20	(	(	-LRB-
cord-015021-pol2qm74	3420	21	AL	AL	NNP
cord-015021-pol2qm74	3420	22	,	,	,
cord-015021-pol2qm74	3420	23	2	2	CD
cord-015021-pol2qm74	3420	24	x	x	SYM
cord-015021-pol2qm74	3420	25	100mg	100mg	NNP
cord-015021-pol2qm74	3420	26	/	/	SYM
cord-015021-pol2qm74	3420	27	kg	kg	NNP
cord-015021-pol2qm74	3420	28	i.p	i.p	NNP
cord-015021-pol2qm74	3420	29	.	.	NNP
cord-015021-pol2qm74	3420	30	)	)	-RRB-
cord-015021-pol2qm74	3420	31	and	and	CC
cord-015021-pol2qm74	3420	32	pyran	pyran	JJ
cord-015021-pol2qm74	3420	33	polymer	polymer	NN
cord-015021-pol2qm74	3420	34	-	-	HYPH
cord-015021-pol2qm74	3420	35	conjugated	conjugate	VBN
cord-015021-pol2qm74	3420	36	superoxide	superoxide	NN
cord-015021-pol2qm74	3420	37	dismutase	dismutase	NN
cord-015021-pol2qm74	3420	38	(	(	-LRB-
cord-015021-pol2qm74	3420	39	SOD	SOD	NNP
cord-015021-pol2qm74	3420	40	,	,	,
cord-015021-pol2qm74	3420	41	2	2	CD
cord-015021-pol2qm74	3420	42	x	x	SYM
cord-015021-pol2qm74	3420	43	200	200	CD
cord-015021-pol2qm74	3420	44	unit	unit	NN
cord-015021-pol2qm74	3420	45	/	/	SYM
cord-015021-pol2qm74	3420	46	mouse	mouse	NN
cord-015021-pol2qm74	3420	47	i.v	i.v	NNP
cord-015021-pol2qm74	3420	48	)	)	-RRB-
cord-015021-pol2qm74	3421	1	r6spectively	r6spectively	RB
cord-015021-pol2qm74	3421	2	.	.	.
cord-015021-pol2qm74	3422	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	3422	2	with	with	IN
cord-015021-pol2qm74	3422	3	AL	AL	NNP
cord-015021-pol2qm74	3422	4	and	and	CC
cord-015021-pol2qm74	3422	5	SOD	SOD	NNP
cord-015021-pol2qm74	3422	6	(	(	-LRB-
cord-015021-pol2qm74	3422	7	24	24	CD
cord-015021-pol2qm74	3422	8	and	and	CC
cord-015021-pol2qm74	3422	9	1	1	CD
cord-015021-pol2qm74	3422	10	hr	hr	NN
cord-015021-pol2qm74	3422	11	prior	prior	RB
cord-015021-pol2qm74	3422	12	to	to	IN
cord-015021-pol2qm74	3422	13	GAIN	gain	VB
cord-015021-pol2qm74	3422	14	/	/	SYM
cord-015021-pol2qm74	3422	15	LPS	LPS	NNP
cord-015021-pol2qm74	3422	16	)	)	-RRB-
cord-015021-pol2qm74	3422	17	prevented	prevent	VBD
cord-015021-pol2qm74	3422	18	GAIN	gain	NN
cord-015021-pol2qm74	3422	19	/	/	SYM
cord-015021-pol2qm74	3422	20	LPS	lp	NNS
cord-015021-pol2qm74	3422	21	hepatitis	hepatitis	NN
cord-015021-pol2qm74	3422	22	and	and	CC
cord-015021-pol2qm74	3422	23	blocked	block	VBD
cord-015021-pol2qm74	3422	24	LPS	LPS	NNP
cord-015021-pol2qm74	3422	25	induced	induce	VBN
cord-015021-pol2qm74	3422	26	released	release	VBN
cord-015021-pol2qm74	3422	27	of	of	IN
cord-015021-pol2qm74	3422	28	TNF	TNF	NNP
cord-015021-pol2qm74	3422	29	and	and	CC
cord-015021-pol2qm74	3422	30	IL-1	IL-1	NNP
cord-015021-pol2qm74	3422	31	into	into	IN
cord-015021-pol2qm74	3422	32	serum	serum	NN
cord-015021-pol2qm74	3422	33	of	of	IN
cord-015021-pol2qm74	3422	34	the	the	DT
cord-015021-pol2qm74	3422	35	mice	mouse	NNS
cord-015021-pol2qm74	3422	36	.	.	.
cord-015021-pol2qm74	3423	1	The	the	DT
cord-015021-pol2qm74	3423	2	protective	protective	JJ
cord-015021-pol2qm74	3423	3	agents	agent	NNS
cord-015021-pol2qm74	3423	4	like	like	IN
cord-015021-pol2qm74	3423	5	cq	cq	NNP
cord-015021-pol2qm74	3423	6	-	-	HYPH
cord-015021-pol2qm74	3423	7	AT	AT	NNP
cord-015021-pol2qm74	3423	8	or	or	CC
cord-015021-pol2qm74	3423	9	AL	AL	NNP
cord-015021-pol2qm74	3423	10	/	/	SYM
cord-015021-pol2qm74	3423	11	SOD	SOD	NNP
cord-015021-pol2qm74	3423	12	did	do	VBD
cord-015021-pol2qm74	3423	13	not	not	RB
cord-015021-pol2qm74	3423	14	protect	protect	VB
cord-015021-pol2qm74	3423	15	the	the	DT
cord-015021-pol2qm74	3423	16	mice	mice	NN
cord-015021-pol2qm74	3423	17	against	against	IN
cord-015021-pol2qm74	3423	18	th~	th~	NNP
cord-015021-pol2qm74	3424	1	hPp	hPp	NNP
cord-015021-pol2qm74	3424	2	~	~	NFP
cord-015021-pol2qm74	3424	3	totoxi£	totoxi£	NNP
cord-015021-pol2qm74	3424	4	ch~	ch~	NN
cord-015021-pol2qm74	3425	1	llPn	llpn	LS
cord-015021-pol2qm74	3425	2	-	-	HYPH
cord-015021-pol2qm74	3425	3	e	e	LS
cord-015021-pol2qm74	3425	4	indllee4	indllee4	NN
cord-015021-pol2qm74	3425	5	b'~	b'~	NNS
cord-015021-pol2qm74	3426	1	th~	th~	NNP
cord-015021-pol2qm74	3426	2	recombinant	recombinant	JJ
cord-015021-pol2qm74	3426	3	mmlse	mmlse	NNP
cord-015021-pol2qm74	3426	4	TNF	TNF	NNP
cord-015021-pol2qm74	3426	5	-	-	HYPH
cord-015021-pol2qm74	3426	6	o	o	NNP
cord-015021-pol2qm74	3426	7	'	'	''
cord-015021-pol2qm74	3426	8	(	(	-LRB-
cord-015021-pol2qm74	3426	9	0.3	0.3	CD
cord-015021-pol2qm74	3426	10	~/rno	~/rno	NNS
cord-015021-pol2qm74	3426	11	~	~	NFP
cord-015021-pol2qm74	3426	12	e	e	NNP
cord-015021-pol2qm74	3426	13	J.p	J.p	NNP
cord-015021-pol2qm74	3426	14	.	.	.
cord-015021-pol2qm74	3426	15	)	)	-RRB-
cord-015021-pol2qm74	3427	1	~d	~d	NNP
cord-015021-pol2qm74	3427	2	oI	oi	UH
cord-015021-pol2qm74	3427	3	~	~	NFP
cord-015021-pol2qm74	3427	4	LPS	LPS	NNP
cord-015021-pol2qm74	3427	5	1~	1~	CD
cord-015021-pol2qm74	3427	6	CAlN-.~dlfa%aed	CAlN-.~dlfa%aed	NNP
cord-015021-pol2qm74	3427	7	mlce	mlce	NNP
cord-015021-pol2qm74	3427	8	.	.	.
cord-015021-pol2qm74	3428	1	It	-PRON-	PRP
cord-015021-pol2qm74	3428	2	-	-	HYPH
cord-015021-pol2qm74	3428	3	l	l	NN
cord-015021-pol2qm74	3428	4	cett	cett	NNP
cord-015021-pol2qm74	3428	5	~	~	NFP
cord-015021-pol2qm74	3428	6	aged	age	VBN
cord-015021-pol2qm74	3428	7	la	la	NNP
cord-015021-pol2qm74	3428	8	TNF	TNF	NNP
cord-015021-pol2qm74	3429	1	(	(	-LRB-
cord-015021-pol2qm74	3429	2	x	x	NN
cord-015021-pol2qm74	3429	3	/	/	SYM
cord-015021-pol2qm74	3429	4	GAIN	gain	VB
cord-015021-pol2qm74	3429	5	treated	treat	VBN
cord-015021-pol2qm74	3429	6	mJde	mJde	NNP
cord-015021-pol2qm74	3429	7	was	be	VBD
cord-015021-pol2qm74	3429	8	not	not	RB
cord-015021-pol2qm74	3429	9	detectable	detectable	JJ
cord-015021-pol2qm74	3429	10	in	in	IN
cord-015021-pol2qm74	3429	11	animals	animal	NNS
cord-015021-pol2qm74	3429	12	pretreated	pretreate	VBN
cord-015021-pol2qm74	3429	13	with	with	IN
cord-015021-pol2qm74	3429	14	oq	oq	NN
cord-015021-pol2qm74	3429	15	-	-	HYPH
cord-015021-pol2qm74	3429	16	AT	at	NN
cord-015021-pol2qm74	3429	17	or	or	CC
cord-015021-pol2qm74	3429	18	AL	AL	NNP
cord-015021-pol2qm74	3429	19	/	/	SYM
cord-015021-pol2qm74	3429	20	SOD	SOD	NNP
cord-015021-pol2qm74	3429	21	.	.	.
cord-015021-pol2qm74	3430	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3430	2	study	study	NN
cord-015021-pol2qm74	3430	3	suggests	suggest	VBZ
cord-015021-pol2qm74	3430	4	that	that	IN
cord-015021-pol2qm74	3430	5	a	a	DT
cord-015021-pol2qm74	3430	6	serine	serine	NN
cord-015021-pol2qm74	3430	7	protease	protease	NN
cord-015021-pol2qm74	3430	8	sensitive	sensitive	JJ
cord-015021-pol2qm74	3430	9	to	to	IN
cord-015021-pol2qm74	3430	10	cq	cq	NN
cord-015021-pol2qm74	3430	11	-	-	HYPH
cord-015021-pol2qm74	3430	12	antitrypsin	antitrypsin	NN
cord-015021-pol2qm74	3430	13	is	be	VBZ
cord-015021-pol2qm74	3430	14	responsible	responsible	JJ
cord-015021-pol2qm74	3430	15	in	in	IN
cord-015021-pol2qm74	3430	16	regulating	regulate	VBG
cord-015021-pol2qm74	3430	17	TNF	TNF	NNP
cord-015021-pol2qm74	3430	18	release	release	NN
cord-015021-pol2qm74	3430	19	,	,	,
cord-015021-pol2qm74	3430	20	possibly	possibly	RB
cord-015021-pol2qm74	3430	21	by	by	IN
cord-015021-pol2qm74	3430	22	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	3430	23	cleavage	cleavage	NN
cord-015021-pol2qm74	3430	24	of	of	IN
cord-015021-pol2qm74	3430	25	a	a	DT
cord-015021-pol2qm74	3430	26	TNF	tnf	NN
cord-015021-pol2qm74	3430	27	-	-	HYPH
cord-015021-pol2qm74	3430	28	precursor	precursor	NN
cord-015021-pol2qm74	3430	29	or	or	CC
cord-015021-pol2qm74	3430	30	membrane	membrane	NN
cord-015021-pol2qm74	3430	31	bound	bind	VBN
cord-015021-pol2qm74	3430	32	TNF	TNF	NNP
cord-015021-pol2qm74	3430	33	.	.	.
cord-015021-pol2qm74	3431	1	In	in	IN
cord-015021-pol2qm74	3431	2	addition	addition	NN
cord-015021-pol2qm74	3431	3	our	-PRON-	PRP$
cord-015021-pol2qm74	3431	4	evidence	evidence	NN
cord-015021-pol2qm74	3431	5	suggest	suggest	VBP
cord-015021-pol2qm74	3431	6	that	that	IN
cord-015021-pol2qm74	3431	7	the	the	DT
cord-015021-pol2qm74	3431	8	balance	balance	NN
cord-015021-pol2qm74	3431	9	of	of	IN
cord-015021-pol2qm74	3431	10	extracellular	extracellular	JJ
cord-015021-pol2qm74	3431	11	protease	protease	NN
cord-015021-pol2qm74	3431	12	/	/	SYM
cord-015021-pol2qm74	3431	13	antiprotease	antiprotease	NN
cord-015021-pol2qm74	3431	14	activity	activity	NN
cord-015021-pol2qm74	3431	15	may	may	MD
cord-015021-pol2qm74	3431	16	be	be	VB
cord-015021-pol2qm74	3431	17	regulated	regulate	VBN
cord-015021-pol2qm74	3431	18	by	by	IN
cord-015021-pol2qm74	3431	19	free	free	JJ
cord-015021-pol2qm74	3431	20	radical	radical	JJ
cord-015021-pol2qm74	3431	21	generation	generation	NN
cord-015021-pol2qm74	3431	22	,	,	,
cord-015021-pol2qm74	3431	23	possible	possible	JJ
cord-015021-pol2qm74	3431	24	superoxide	superoxide	NN
cord-015021-pol2qm74	3431	25	anion	anion	NN
cord-015021-pol2qm74	3431	26	,	,	,
cord-015021-pol2qm74	3431	27	resulting	result	VBG
cord-015021-pol2qm74	3431	28	in	in	IN
cord-015021-pol2qm74	3431	29	inactivation	inactivation	NN
cord-015021-pol2qm74	3431	30	of	of	IN
cord-015021-pol2qm74	3431	31	the	the	DT
cord-015021-pol2qm74	3431	32	antiprotease	antiprotease	NN
cord-015021-pol2qm74	3431	33	.	.	.
cord-015021-pol2qm74	3432	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	3433	1	release	release	NN
cord-015021-pol2qm74	3433	2	may	may	MD
cord-015021-pol2qm74	3433	3	be	be	VB
cord-015021-pol2qm74	3433	4	subsequent	subsequent	JJ
cord-015021-pol2qm74	3433	5	to	to	IN
cord-015021-pol2qm74	3433	6	TNF	TNF	NNP
cord-015021-pol2qm74	3433	7	release	release	NN
cord-015021-pol2qm74	3433	8	.	.	.
cord-015021-pol2qm74	3434	1	Objective	objective	JJ
cord-015021-pol2qm74	3434	2	:	:	:
cord-015021-pol2qm74	3434	3	During	during	IN
cord-015021-pol2qm74	3434	4	sepsis	sepsis	NN
cord-015021-pol2qm74	3434	5	one	one	PRP
cord-015021-pol2qm74	3434	6	can	can	MD
cord-015021-pol2qm74	3434	7	observe	observe	VB
cord-015021-pol2qm74	3434	8	a	a	DT
cord-015021-pol2qm74	3434	9	dramatically	dramatically	RB
cord-015021-pol2qm74	3434	10	impaired	impair	VBN
cord-015021-pol2qm74	3434	11	production	production	NN
cord-015021-pol2qm74	3434	12	of	of	IN
cord-015021-pol2qm74	3434	13	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3434	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	3434	15	like	like	IN
cord-015021-pol2qm74	3434	16	the	the	DT
cord-015021-pol2qm74	3434	17	Tumor	tumor	NN
cord-015021-pol2qm74	3434	18	necrosis	necrosis	NN
cord-015021-pol2qm74	3434	19	factor	factor	NN
cord-015021-pol2qm74	3434	20	alpha	alpha	NN
cord-015021-pol2qm74	3434	21	(	(	-LRB-
cord-015021-pol2qm74	3434	22	TNF	TNF	NNP
cord-015021-pol2qm74	3434	23	-	-	HYPH
cord-015021-pol2qm74	3434	24	a	a	NNP
cord-015021-pol2qm74	3434	25	)	)	-RRB-
cord-015021-pol2qm74	3434	26	,	,	,
cord-015021-pol2qm74	3434	27	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	3434	28	I	i	NN
cord-015021-pol2qm74	3434	29	-	-	HYPH
cord-015021-pol2qm74	3434	30	alpha	alpha	NN
cord-015021-pol2qm74	3435	1	(	(	-LRB-
cord-015021-pol2qm74	3435	2	IL	IL	NNP
cord-015021-pol2qm74	3435	3	-	-	HYPH
cord-015021-pol2qm74	3435	4	la	la	NNP
cord-015021-pol2qm74	3435	5	)	)	-RRB-
cord-015021-pol2qm74	3436	1	,	,	,
cord-015021-pol2qm74	3436	2	Intedeukin	Intedeukin	NNP
cord-015021-pol2qm74	3436	3	I	i	NN
cord-015021-pol2qm74	3436	4	-	-	HYPH
cord-015021-pol2qm74	3436	5	beta	beta	NN
cord-015021-pol2qm74	3437	1	(	(	-LRB-
cord-015021-pol2qm74	3437	2	IL	IL	NNP
cord-015021-pol2qm74	3437	3	-	-	HYPH
cord-015021-pol2qm74	3437	4	I	I	NNP
cord-015021-pol2qm74	3437	5	&	&	CC
cord-015021-pol2qm74	3437	6	)	)	-RRB-
cord-015021-pol2qm74	3437	7	and	and	CC
cord-015021-pol2qm74	3437	8	Interferon	Interferon	NNP
cord-015021-pol2qm74	3437	9	gamma	gamma	NN
cord-015021-pol2qm74	3437	10	(	(	-LRB-
cord-015021-pol2qm74	3437	11	IF~	IF~	NNP
cord-015021-pol2qm74	3437	12	)	)	-RRB-
cord-015021-pol2qm74	3437	13	upon	upon	IN
cord-015021-pol2qm74	3437	14	in	in	IN
cord-015021-pol2qm74	3437	15	vitro	vitro	FW
cord-015021-pol2qm74	3437	16	stimulation	stimulation	NN
cord-015021-pol2qm74	3437	17	of	of	IN
cord-015021-pol2qm74	3437	18	circulating	circulate	VBG
cord-015021-pol2qm74	3437	19	cells	cell	NNS
cord-015021-pol2qm74	3437	20	.	.	.
cord-015021-pol2qm74	3438	1	However	however	RB
cord-015021-pol2qm74	3438	2	there	there	EX
cord-015021-pol2qm74	3438	3	is	be	VBZ
cord-015021-pol2qm74	3438	4	also	also	RB
cord-015021-pol2qm74	3438	5	evidence	evidence	NN
cord-015021-pol2qm74	3438	6	of	of	IN
cord-015021-pol2qm74	3438	7	a	a	DT
cord-015021-pol2qm74	3438	8	decreased	decrease	VBN
cord-015021-pol2qm74	3438	9	ability	ability	NN
cord-015021-pol2qm74	3438	10	to	to	TO
cord-015021-pol2qm74	3438	11	produce	produce	VB
cord-015021-pol2qm74	3438	12	cytokines	cytokine	NNS
cord-015021-pol2qm74	3438	13	in	in	IN
cord-015021-pol2qm74	3438	14	other	other	JJ
cord-015021-pol2qm74	3438	15	immuno	immuno	JJ
cord-015021-pol2qm74	3438	16	-	-	HYPH
cord-015021-pol2qm74	3438	17	deficient	deficient	JJ
cord-015021-pol2qm74	3438	18	states	state	NNS
cord-015021-pol2qm74	3438	19	.	.	.
cord-015021-pol2qm74	3439	1	In	in	IN
cord-015021-pol2qm74	3439	2	this	this	DT
cord-015021-pol2qm74	3439	3	study	study	NN
cord-015021-pol2qm74	3439	4	we	-PRON-	PRP
cord-015021-pol2qm74	3439	5	compared	compare	VBD
cord-015021-pol2qm74	3439	6	the	the	DT
cord-015021-pol2qm74	3439	7	capacity	capacity	NN
cord-015021-pol2qm74	3439	8	to	to	TO
cord-015021-pol2qm74	3439	9	secrete	secrete	VB
cord-015021-pol2qm74	3439	10	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3439	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	3439	12	upon	upon	IN
cord-015021-pol2qm74	3439	13	in	in	IN
cord-015021-pol2qm74	3439	14	vitro	vitro	FW
cord-015021-pol2qm74	3439	15	stimulation	stimulation	NN
cord-015021-pol2qm74	3439	16	of	of	IN
cord-015021-pol2qm74	3439	17	patients	patient	NNS
cord-015021-pol2qm74	3439	18	in	in	IN
cord-015021-pol2qm74	3439	19	severe	severe	JJ
cord-015021-pol2qm74	3439	20	sepsis	sepsis	NN
cord-015021-pol2qm74	3439	21	and	and	CC
cord-015021-pol2qm74	3439	22	patients	patient	NNS
cord-015021-pol2qm74	3439	23	with	with	IN
cord-015021-pol2qm74	3439	24	malignant	malignant	JJ
cord-015021-pol2qm74	3439	25	tumors	tumor	NNS
cord-015021-pol2qm74	3439	26	.	.	.
cord-015021-pol2qm74	3440	1	Methods	method	NNS
cord-015021-pol2qm74	3440	2	:	:	:
cord-015021-pol2qm74	3441	1	Heparinized	heparinize	VBN
cord-015021-pol2qm74	3441	2	blood	blood	NN
cord-015021-pol2qm74	3441	3	samples	sample	NNS
cord-015021-pol2qm74	3441	4	of	of	IN
cord-015021-pol2qm74	3441	5	ten	ten	CD
cord-015021-pol2qm74	3441	6	patients	patient	NNS
cord-015021-pol2qm74	3441	7	(	(	-LRB-
cord-015021-pol2qm74	3441	8	62	62	CD
cord-015021-pol2qm74	3441	9	+	+	SYM
cord-015021-pol2qm74	3441	10	14	14	CD
cord-015021-pol2qm74	3441	11	years	year	NNS
cord-015021-pol2qm74	3441	12	)	)	-RRB-
cord-015021-pol2qm74	3441	13	in	in	IN
cord-015021-pol2qm74	3441	14	severe	severe	JJ
cord-015021-pol2qm74	3441	15	sepsis	sepsis	NN
cord-015021-pol2qm74	3442	1	(	(	-LRB-
cord-015021-pol2qm74	3442	2	sepsis	sepsis	NN
cord-015021-pol2qm74	3442	3	score	score	NN
cord-015021-pol2qm74	3442	4	>	>	XX
cord-015021-pol2qm74	3443	1	15	15	CD
cord-015021-pol2qm74	3444	1	according	accord	VBG
cord-015021-pol2qm74	3444	2	to	to	IN
cord-015021-pol2qm74	3444	3	E}ebute	e}ebute	CD
cord-015021-pol2qm74	3444	4	and	and	CC
cord-015021-pol2qm74	3444	5	Stoner	Stoner	NNP
cord-015021-pol2qm74	3444	6	)	)	-RRB-
cord-015021-pol2qm74	3444	7	were	be	VBD
cord-015021-pol2qm74	3444	8	drawn	draw	VBN
cord-015021-pol2qm74	3444	9	at	at	IN
cord-015021-pol2qm74	3444	10	onset	onset	NN
cord-015021-pol2qm74	3444	11	of	of	IN
cord-015021-pol2qm74	3444	12	disease	disease	NN
cord-015021-pol2qm74	3444	13	,	,	,
cord-015021-pol2qm74	3444	14	From	from	IN
cord-015021-pol2qm74	3444	15	fifteen	fifteen	CD
cord-015021-pol2qm74	3444	16	patients	patient	NNS
cord-015021-pol2qm74	3444	17	with	with	IN
cord-015021-pol2qm74	3444	18	solid	solid	JJ
cord-015021-pol2qm74	3444	19	growing	grow	VBG
cord-015021-pol2qm74	3444	20	carcinoma	carcinoma	NN
cord-015021-pol2qm74	3444	21	(	(	-LRB-
cord-015021-pol2qm74	3444	22	59	59	CD
cord-015021-pol2qm74	3444	23	+	+	SYM
cord-015021-pol2qm74	3444	24	19	19	CD
cord-015021-pol2qm74	3444	25	years	year	NNS
cord-015021-pol2qm74	3444	26	)	)	-RRB-
cord-015021-pol2qm74	3444	27	blood	blood	NN
cord-015021-pol2qm74	3444	28	was	be	VBD
cord-015021-pol2qm74	3444	29	drawn	draw	VBN
cord-015021-pol2qm74	3444	30	at	at	IN
cord-015021-pol2qm74	3444	31	diagnosis	diagnosis	NN
cord-015021-pol2qm74	3444	32	prior	prior	RB
cord-015021-pol2qm74	3444	33	to	to	IN
cord-015021-pol2qm74	3444	34	any	any	DT
cord-015021-pol2qm74	3444	35	therapy	therapy	NN
cord-015021-pol2qm74	3444	36	.	.	.
cord-015021-pol2qm74	3445	1	Controls	control	NNS
cord-015021-pol2qm74	3445	2	were	be	VBD
cord-015021-pol2qm74	3445	3	obtained	obtain	VBN
cord-015021-pol2qm74	3445	4	from	from	IN
cord-015021-pol2qm74	3445	5	fifteen	fifteen	CD
cord-015021-pol2qm74	3445	6	healthy	healthy	JJ
cord-015021-pol2qm74	3445	7	volunteers	volunteer	NNS
cord-015021-pol2qm74	3445	8	.	.	.
cord-015021-pol2qm74	3446	1	50	50	CD
cord-015021-pol2qm74	3446	2	pl	pl	NNS
cord-015021-pol2qm74	3446	3	of	of	IN
cord-015021-pol2qm74	3446	4	whole	whole	JJ
cord-015021-pol2qm74	3446	5	blood	blood	NN
cord-015021-pol2qm74	3446	6	were	be	VBD
cord-015021-pol2qm74	3446	7	incubated	incubate	VBN
cord-015021-pol2qm74	3446	8	either	either	CC
cord-015021-pol2qm74	3446	9	with	with	IN
cord-015021-pol2qm74	3446	10	450/4	450/4	CD
cord-015021-pol2qm74	3446	11	of	of	IN
cord-015021-pol2qm74	3446	12	a	a	DT
cord-015021-pol2qm74	3446	13	standard	standard	JJ
cord-015021-pol2qm74	3446	14	medium	medium	NN
cord-015021-pol2qm74	3446	15	or	or	CC
cord-015021-pol2qm74	3446	16	with	with	IN
cord-015021-pol2qm74	3446	17	400	400	CD
cord-015021-pol2qm74	3446	18	pl	pl	NNS
cord-015021-pol2qm74	3446	19	of	of	IN
cord-015021-pol2qm74	3446	20	a	a	DT
cord-015021-pol2qm74	3446	21	standard	standard	JJ
cord-015021-pol2qm74	3446	22	medium	medium	NN
cord-015021-pol2qm74	3446	23	and	and	CC
cord-015021-pol2qm74	3446	24	50	50	CD
cord-015021-pol2qm74	3446	25	pl	pl	NNS
cord-015021-pol2qm74	3446	26	of	of	IN
cord-015021-pol2qm74	3446	27	phytohemagglutinin	phytohemagglutinin	NN
cord-015021-pol2qm74	3446	28	(	(	-LRB-
cord-015021-pol2qm74	3446	29	PHA	PHA	NNP
cord-015021-pol2qm74	3446	30	)	)	-RRB-
cord-015021-pol2qm74	3446	31	a	a	DT
cord-015021-pol2qm74	3446	32	potent	potent	JJ
cord-015021-pol2qm74	3446	33	mitogen	mitogen	NN
cord-015021-pol2qm74	3446	34	.	.	.
cord-015021-pol2qm74	3447	1	After	after	IN
cord-015021-pol2qm74	3447	2	an	an	DT
cord-015021-pol2qm74	3447	3	incubation	incubation	NN
cord-015021-pol2qm74	3447	4	period	period	NN
cord-015021-pol2qm74	3447	5	of	of	IN
cord-015021-pol2qm74	3447	6	24	24	CD
cord-015021-pol2qm74	3447	7	hours	hour	NNS
cord-015021-pol2qm74	3447	8	plasma	plasma	NN
cord-015021-pol2qm74	3447	9	concentrations	concentration	NNS
cord-015021-pol2qm74	3447	10	of	of	IN
cord-015021-pol2qm74	3447	11	TNF	TNF	NNP
cord-015021-pol2qm74	3447	12	-	-	HYPH
cord-015021-pol2qm74	3447	13	a	a	NNP
cord-015021-pol2qm74	3447	14	,	,	,
cord-015021-pol2qm74	3447	15	IL	IL	NNP
cord-015021-pol2qm74	3447	16	-	-	HYPH
cord-015021-pol2qm74	3447	17	la	la	NNP
cord-015021-pol2qm74	3447	18	,	,	,
cord-015021-pol2qm74	3447	19	IL-16	IL-16	NNP
cord-015021-pol2qm74	3447	20	and	and	CC
cord-015021-pol2qm74	3447	21	IF-~	IF-~	NNP
cord-015021-pol2qm74	3447	22	were	be	VBD
cord-015021-pol2qm74	3447	23	determined	determine	VBN
cord-015021-pol2qm74	3447	24	by	by	IN
cord-015021-pol2qm74	3447	25	ELISA	ELISA	NNP
cord-015021-pol2qm74	3447	26	.	.	.
cord-015021-pol2qm74	3448	1	Comments	comment	NNS
cord-015021-pol2qm74	3448	2	:	:	:
cord-015021-pol2qm74	3449	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3449	2	results	result	NNS
cord-015021-pol2qm74	3449	3	suggest	suggest	VBP
cord-015021-pol2qm74	3449	4	that	that	IN
cord-015021-pol2qm74	3449	5	down	down	IN
cord-015021-pol2qm74	3449	6	-	-	HYPH
cord-015021-pol2qm74	3449	7	regulation	regulation	NN
cord-015021-pol2qm74	3449	8	of	of	IN
cord-015021-pol2qm74	3449	9	cytokine	cytokine	JJ
cord-015021-pol2qm74	3449	10	secretion	secretion	NN
cord-015021-pol2qm74	3449	11	or	or	CC
cord-015021-pol2qm74	3449	12	of	of	IN
cord-015021-pol2qm74	3449	13	cell	cell	NN
cord-015021-pol2qm74	3449	14	responsiveness	responsiveness	NN
cord-015021-pol2qm74	3449	15	to	to	IN
cord-015021-pol2qm74	3449	16	non	non	JJ
cord-015021-pol2qm74	3449	17	-	-	JJ
cord-015021-pol2qm74	3449	18	specific	specific	JJ
cord-015021-pol2qm74	3449	19	mitogens	mitogen	NNS
cord-015021-pol2qm74	3449	20	during	during	IN
cord-015021-pol2qm74	3449	21	sepsis	sepsis	NN
cord-015021-pol2qm74	3449	22	has	have	VBZ
cord-015021-pol2qm74	3449	23	occurred	occur	VBN
cord-015021-pol2qm74	3449	24	.	.	.
cord-015021-pol2qm74	3450	1	We	-PRON-	PRP
cord-015021-pol2qm74	3450	2	observe	observe	VBP
cord-015021-pol2qm74	3450	3	a	a	DT
cord-015021-pol2qm74	3450	4	similar	similar	JJ
cord-015021-pol2qm74	3450	5	phenomenon	phenomenon	NN
cord-015021-pol2qm74	3450	6	for	for	IN
cord-015021-pol2qm74	3450	7	the	the	DT
cord-015021-pol2qm74	3450	8	group	group	NN
cord-015021-pol2qm74	3450	9	of	of	IN
cord-015021-pol2qm74	3450	10	carcinoma	carcinoma	JJ
cord-015021-pol2qm74	3450	11	patients	patient	NNS
cord-015021-pol2qm74	3450	12	vs	vs	IN
cord-015021-pol2qm74	3450	13	control	control	NN
cord-015021-pol2qm74	3450	14	significant	significant	JJ
cord-015021-pol2qm74	3450	15	for	for	IN
cord-015021-pol2qm74	3450	16	stimulated	stimulate	VBN
cord-015021-pol2qm74	3450	17	TNF	TNF	NNP
cord-015021-pol2qm74	3450	18	-	-	,
cord-015021-pol2qm74	3450	19	a	a	NNP
cord-015021-pol2qm74	3450	20	and	and	CC
cord-015021-pol2qm74	3450	21	stimulated	stimulate	VBN
cord-015021-pol2qm74	3451	1	IF	if	NN
cord-015021-pol2qm74	3451	2	-	-	HYPH
cord-015021-pol2qm74	3451	3	T.	t.	NN
cord-015021-pol2qm74	3451	4	Sustained	sustained	JJ
cord-015021-pol2qm74	3451	5	immunological	immunological	JJ
cord-015021-pol2qm74	3451	6	interactions	interaction	NNS
cord-015021-pol2qm74	3451	7	between	between	IN
cord-015021-pol2qm74	3451	8	tumorcells	tumorcell	NNS
cord-015021-pol2qm74	3451	9	and	and	CC
cord-015021-pol2qm74	3451	10	cytokine	cytokine	NN
cord-015021-pol2qm74	3451	11	producing	produce	VBG
cord-015021-pol2qm74	3451	12	cells	cell	NNS
cord-015021-pol2qm74	3451	13	could	could	MD
cord-015021-pol2qm74	3451	14	effect	effect	VB
cord-015021-pol2qm74	3451	15	responsiveness	responsiveness	NN
cord-015021-pol2qm74	3451	16	of	of	IN
cord-015021-pol2qm74	3451	17	the	the	DT
cord-015021-pol2qm74	3451	18	latter	latter	JJ
cord-015021-pol2qm74	3451	19	,	,	,
cord-015021-pol2qm74	3451	20	A	a	DT
cord-015021-pol2qm74	3451	21	general	general	JJ
cord-015021-pol2qm74	3451	22	increased	increase	VBN
cord-015021-pol2qm74	3451	23	immuno	immuno	JJ
cord-015021-pol2qm74	3451	24	-	-	JJ
cord-015021-pol2qm74	3451	25	tolerant	tolerant	JJ
cord-015021-pol2qm74	3451	26	state	state	NN
cord-015021-pol2qm74	3451	27	in	in	IN
cord-015021-pol2qm74	3451	28	patients	patient	NNS
cord-015021-pol2qm74	3451	29	with	with	IN
cord-015021-pol2qm74	3451	30	carcinoma	carcinoma	NN
cord-015021-pol2qm74	3451	31	has	have	VBZ
cord-015021-pol2qm74	3451	32	to	to	TO
cord-015021-pol2qm74	3451	33	be	be	VB
cord-015021-pol2qm74	3451	34	discussed	discuss	VBN
cord-015021-pol2qm74	3451	35	.	.	.
cord-015021-pol2qm74	3452	1	However	however	RB
cord-015021-pol2qm74	3452	2	we	-PRON-	PRP
cord-015021-pol2qm74	3452	3	found	find	VBD
cord-015021-pol2qm74	3452	4	significant	significant	JJ
cord-015021-pol2qm74	3452	5	differences	difference	NNS
cord-015021-pol2qm74	3452	6	between	between	IN
cord-015021-pol2qm74	3452	7	sepsis	sepsis	NN
cord-015021-pol2qm74	3452	8	and	and	CC
cord-015021-pol2qm74	3452	9	cancer	cancer	NN
cord-015021-pol2qm74	3452	10	concerning	concern	VBG
cord-015021-pol2qm74	3452	11	the	the	DT
cord-015021-pol2qm74	3452	12	in	in	FW
cord-015021-pol2qm74	3452	13	vitro	vitro	FW
cord-015021-pol2qm74	3452	14	capacity	capacity	NN
cord-015021-pol2qm74	3452	15	of	of	IN
cord-015021-pol2qm74	3452	16	responsable	responsable	JJ
cord-015021-pol2qm74	3452	17	cells	cell	NNS
cord-015021-pol2qm74	3452	18	to	to	TO
cord-015021-pol2qm74	3452	19	produce	produce	VB
cord-015021-pol2qm74	3452	20	IL	IL	NNP
cord-015021-pol2qm74	3452	21	-	-	HYPH
cord-015021-pol2qm74	3452	22	la	la	NNP
cord-015021-pol2qm74	3452	23	and	and	CC
cord-015021-pol2qm74	3452	24	IL	IL	NNP
cord-015021-pol2qm74	3452	25	-	-	:
cord-015021-pol2qm74	3452	26	I	I	NNP
cord-015021-pol2qm74	3452	27	#	#	NN
cord-015021-pol2qm74	3452	28	.	.	.
cord-015021-pol2qm74	3453	1	The	the	DT
cord-015021-pol2qm74	3453	2	dramatically	dramatically	RB
cord-015021-pol2qm74	3453	3	decrease	decrease	NN
cord-015021-pol2qm74	3453	4	of	of	IN
cord-015021-pol2qm74	3453	5	the	the	DT
cord-015021-pol2qm74	3453	6	ability	ability	NN
cord-015021-pol2qm74	3453	7	to	to	TO
cord-015021-pol2qm74	3453	8	produce	produce	VB
cord-015021-pol2qm74	3453	9	IL	IL	NNP
cord-015021-pol2qm74	3453	10	-	-	:
cord-015021-pol2qm74	3453	11	I	-PRON-	PRP
cord-015021-pol2qm74	3453	12	upon	upon	IN
cord-015021-pol2qm74	3453	13	in	in	IN
cord-015021-pol2qm74	3453	14	vitro	vitro	FW
cord-015021-pol2qm74	3453	15	stimulation	stimulation	NN
cord-015021-pol2qm74	3453	16	could	could	MD
cord-015021-pol2qm74	3453	17	be	be	VB
cord-015021-pol2qm74	3453	18	more	more	RBR
cord-015021-pol2qm74	3453	19	sensitive	sensitive	JJ
cord-015021-pol2qm74	3453	20	for	for	IN
cord-015021-pol2qm74	3453	21	a	a	DT
cord-015021-pol2qm74	3453	22	septic	septic	JJ
cord-015021-pol2qm74	3453	23	state	state	NN
cord-015021-pol2qm74	3453	24	than	than	IN
cord-015021-pol2qm74	3453	25	stimulated	stimulate	VBN
cord-015021-pol2qm74	3453	26	TNF	TNF	NNP
cord-015021-pol2qm74	3453	27	-	-	:
cord-015021-pol2qm74	3453	28	a	a	NN
cord-015021-pol2qm74	3453	29	or	or	CC
cord-015021-pol2qm74	3453	30	IF-3	IF-3	NNP
cord-015021-pol2qm74	3453	31	,	,	,
cord-015021-pol2qm74	3453	32	.	.	.
cord-015021-pol2qm74	3454	1	Objective	objective	NN
cord-015021-pol2qm74	3454	2	:	:	:
cord-015021-pol2qm74	3455	1	Tumor	tumor	NN
cord-015021-pol2qm74	3455	2	necrosis	necrosis	NN
cord-015021-pol2qm74	3455	3	factor	factor	NN
cord-015021-pol2qm74	3455	4	alpha	alpha	NN
cord-015021-pol2qm74	3455	5	(	(	-LRB-
cord-015021-pol2qm74	3455	6	TNF	TNF	NNP
cord-015021-pol2qm74	3455	7	-	-	HYPH
cord-015021-pol2qm74	3455	8	a	a	NN
cord-015021-pol2qm74	3455	9	)	)	-RRB-
cord-015021-pol2qm74	3455	10	has	have	VBZ
cord-015021-pol2qm74	3455	11	been	be	VBN
cord-015021-pol2qm74	3455	12	implicated	implicate	VBN
cord-015021-pol2qm74	3455	13	as	as	IN
cord-015021-pol2qm74	3455	14	a	a	DT
cord-015021-pol2qm74	3455	15	central	central	JJ
cord-015021-pol2qm74	3455	16	mediator	mediator	NN
cord-015021-pol2qm74	3455	17	of	of	IN
cord-015021-pol2qm74	3455	18	sepsis	sepsis	NN
cord-015021-pol2qm74	3455	19	and	and	CC
cord-015021-pol2qm74	3455	20	its	-PRON-	PRP$
cord-015021-pol2qm74	3455	21	sequelae	sequela	NNS
cord-015021-pol2qm74	3455	22	.	.	.
cord-015021-pol2qm74	3456	1	Increased	increase	VBN
cord-015021-pol2qm74	3456	2	systemic	systemic	JJ
cord-015021-pol2qm74	3456	3	levels	level	NNS
cord-015021-pol2qm74	3456	4	of	of	IN
cord-015021-pol2qm74	3456	5	this	this	DT
cord-015021-pol2qm74	3456	6	cytoklne	cytoklne	NN
cord-015021-pol2qm74	3456	7	seem	seem	VBP
cord-015021-pol2qm74	3456	8	to	to	TO
cord-015021-pol2qm74	3456	9	be	be	VB
cord-015021-pol2qm74	3456	10	correlated	correlate	VBN
cord-015021-pol2qm74	3456	11	with	with	IN
cord-015021-pol2qm74	3456	12	severity	severity	NN
cord-015021-pol2qm74	3456	13	of	of	IN
cord-015021-pol2qm74	3456	14	sepsis	sepsis	NN
cord-015021-pol2qm74	3456	15	and	and	CC
cord-015021-pol2qm74	3456	16	outcome	outcome	NN
cord-015021-pol2qm74	3456	17	.	.	.
cord-015021-pol2qm74	3457	1	However	however	RB
cord-015021-pol2qm74	3457	2	mechanism	mechanism	NN
cord-015021-pol2qm74	3457	3	of	of	IN
cord-015021-pol2qm74	3457	4	action	action	NN
cord-015021-pol2qm74	3457	5	and	and	CC
cord-015021-pol2qm74	3457	6	metabolism	metabolism	NN
cord-015021-pol2qm74	3457	7	of	of	IN
cord-015021-pol2qm74	3457	8	TNF	TNF	NNP
cord-015021-pol2qm74	3457	9	-	-	HYPH
cord-015021-pol2qm74	3457	10	G	G	NNP
cord-015021-pol2qm74	3457	11	are	be	VBP
cord-015021-pol2qm74	3457	12	not	not	RB
cord-015021-pol2qm74	3457	13	fully	fully	RB
cord-015021-pol2qm74	3457	14	understood	understand	VBN
cord-015021-pol2qm74	3457	15	.	.	.
cord-015021-pol2qm74	3458	1	In	in	IN
cord-015021-pol2qm74	3458	2	most	most	JJS
cord-015021-pol2qm74	3458	3	studies	study	NNS
cord-015021-pol2qm74	3458	4	blood	blood	NN
cord-015021-pol2qm74	3458	5	samples	sample	NNS
cord-015021-pol2qm74	3458	6	for	for	IN
cord-015021-pol2qm74	3458	7	TNF	TNF	NNP
cord-015021-pol2qm74	3458	8	-	-	:
cord-015021-pol2qm74	3458	9	a	a	DT
cord-015021-pol2qm74	3458	10	determinations	determination	NNS
cord-015021-pol2qm74	3458	11	are	be	VBP
cord-015021-pol2qm74	3458	12	obtained	obtain	VBN
cord-015021-pol2qm74	3458	13	either	either	CC
cord-015021-pol2qm74	3458	14	by	by	IN
cord-015021-pol2qm74	3458	15	peripheral	peripheral	JJ
cord-015021-pol2qm74	3458	16	venipuncture	venipuncture	NN
cord-015021-pol2qm74	3458	17	,	,	,
cord-015021-pol2qm74	3458	18	a	a	DT
cord-015021-pol2qm74	3458	19	central	central	JJ
cord-015021-pol2qm74	3458	20	venous	venous	JJ
cord-015021-pol2qm74	3458	21	catheter	catheter	NN
cord-015021-pol2qm74	3458	22	or	or	CC
cord-015021-pol2qm74	3458	23	by	by	IN
cord-015021-pol2qm74	3458	24	an	an	DT
cord-015021-pol2qm74	3458	25	indwelling	indwell	VBG
cord-015021-pol2qm74	3458	26	arterial	arterial	JJ
cord-015021-pol2qm74	3458	27	catheter	catheter	NN
cord-015021-pol2qm74	3458	28	.	.	.
cord-015021-pol2qm74	3459	1	Very	very	RB
cord-015021-pol2qm74	3459	2	often	often	RB
cord-015021-pol2qm74	3459	3	blood	blood	NN
cord-015021-pol2qm74	3459	4	samples	sample	NNS
cord-015021-pol2qm74	3459	5	are	be	VBP
cord-015021-pol2qm74	3459	6	taken	take	VBN
cord-015021-pol2qm74	3459	7	in	in	IN
cord-015021-pol2qm74	3459	8	different	different	JJ
cord-015021-pol2qm74	3459	9	manners	manner	NNS
cord-015021-pol2qm74	3459	10	within	within	IN
cord-015021-pol2qm74	3459	11	the	the	DT
cord-015021-pol2qm74	3459	12	same	same	JJ
cord-015021-pol2qm74	3459	13	study	study	NN
cord-015021-pol2qm74	3459	14	.	.	.
cord-015021-pol2qm74	3460	1	In	in	IN
cord-015021-pol2qm74	3460	2	this	this	DT
cord-015021-pol2qm74	3460	3	study	study	NN
cord-015021-pol2qm74	3460	4	we	-PRON-	PRP
cord-015021-pol2qm74	3460	5	measured	measure	VBD
cord-015021-pol2qm74	3460	6	circulating	circulate	VBG
cord-015021-pol2qm74	3460	7	TNF	TNF	NNP
cord-015021-pol2qm74	3460	8	-	-	:
cord-015021-pol2qm74	3460	9	a	a	NN
cord-015021-pol2qm74	3460	10	and	and	CC
cord-015021-pol2qm74	3460	11	the	the	DT
cord-015021-pol2qm74	3460	12	amount	amount	NN
cord-015021-pol2qm74	3460	13	of	of	IN
cord-015021-pol2qm74	3460	14	TNF	TNF	NNP
cord-015021-pol2qm74	3460	15	-	-	:
cord-015021-pol2qm74	3460	16	a	a	DT
cord-015021-pol2qm74	3460	17	released	release	VBN
cord-015021-pol2qm74	3460	18	upon	upon	IN
cord-015021-pol2qm74	3460	19	in	in	FW
cord-015021-pol2qm74	3460	20	vitro	vitro	FW
cord-015021-pol2qm74	3460	21	stimulation	stimulation	NN
cord-015021-pol2qm74	3460	22	in	in	IN
cord-015021-pol2qm74	3460	23	arterial	arterial	JJ
cord-015021-pol2qm74	3460	24	and	and	CC
cord-015021-pol2qm74	3460	25	central	central	JJ
cord-015021-pol2qm74	3460	26	venous	venous	JJ
cord-015021-pol2qm74	3460	27	blood	blood	NN
cord-015021-pol2qm74	3460	28	.	.	.
cord-015021-pol2qm74	3461	1	Methods	method	NNS
cord-015021-pol2qm74	3461	2	:	:	:
cord-015021-pol2qm74	3462	1	Heparlnized	heparlnized	JJ
cord-015021-pol2qm74	3462	2	arterial	arterial	JJ
cord-015021-pol2qm74	3462	3	and	and	CC
cord-015021-pol2qm74	3462	4	central	central	JJ
cord-015021-pol2qm74	3462	5	venous	venous	JJ
cord-015021-pol2qm74	3462	6	blood	blood	NN
cord-015021-pol2qm74	3462	7	samples	sample	NNS
cord-015021-pol2qm74	3462	8	of	of	IN
cord-015021-pol2qm74	3462	9	ten	ten	CD
cord-015021-pol2qm74	3462	10	patients	patient	NNS
cord-015021-pol2qm74	3462	11	(	(	-LRB-
cord-015021-pol2qm74	3462	12	6	6	CD
cord-015021-pol2qm74	3462	13	males	male	NNS
cord-015021-pol2qm74	3462	14	,	,	,
cord-015021-pol2qm74	3462	15	4	4	CD
cord-015021-pol2qm74	3462	16	females	female	NNS
cord-015021-pol2qm74	3462	17	,	,	,
cord-015021-pol2qm74	3462	18	mean	mean	VB
cord-015021-pol2qm74	3462	19	age	age	NN
cord-015021-pol2qm74	3462	20	62+_14	62+_14	NNP
cord-015021-pol2qm74	3462	21	)	)	-RRB-
cord-015021-pol2qm74	3462	22	with	with	IN
cord-015021-pol2qm74	3462	23	severe	severe	JJ
cord-015021-pol2qm74	3462	24	sepsis	sepsis	NN
cord-015021-pol2qm74	3463	1	(	(	-LRB-
cord-015021-pol2qm74	3463	2	sepsis	sepsis	NN
cord-015021-pol2qm74	3463	3	score	score	NN
cord-015021-pol2qm74	3463	4	>	>	XX
cord-015021-pol2qm74	3463	5	15	15	CD
cord-015021-pol2qm74	3463	6	,	,	,
cord-015021-pol2qm74	3463	7	Elebute	Elebute	NNP
cord-015021-pol2qm74	3463	8	and	and	CC
cord-015021-pol2qm74	3463	9	Stoner	Stoner	NNP
cord-015021-pol2qm74	3463	10	}	}	-RRB-
cord-015021-pol2qm74	3463	11	were	be	VBD
cord-015021-pol2qm74	3463	12	drawn	draw	VBN
cord-015021-pol2qm74	3463	13	on	on	IN
cord-015021-pol2qm74	3463	14	day	day	NN
cord-015021-pol2qm74	3463	15	1,3,6,8	1,3,6,8	CD
cord-015021-pol2qm74	3463	16	,	,	,
cord-015021-pol2qm74	3463	17	and	and	CC
cord-015021-pol2qm74	3463	18	14	14	CD
cord-015021-pol2qm74	3463	19	of	of	IN
cord-015021-pol2qm74	3463	20	disease	disease	NN
cord-015021-pol2qm74	3463	21	.	.	.
cord-015021-pol2qm74	3464	1	Blood	blood	NN
cord-015021-pol2qm74	3464	2	was	be	VBD
cord-015021-pol2qm74	3464	3	immediately	immediately	RB
cord-015021-pol2qm74	3464	4	placed	place	VBN
cord-015021-pol2qm74	3464	5	on	on	IN
cord-015021-pol2qm74	3464	6	ice	ice	NN
cord-015021-pol2qm74	3464	7	and	and	CC
cord-015021-pol2qm74	3464	8	processed	process	VBN
cord-015021-pol2qm74	3464	9	within	within	IN
cord-015021-pol2qm74	3464	10	1	1	CD
cord-015021-pol2qm74	3464	11	hour	hour	NN
cord-015021-pol2qm74	3464	12	.	.	.
cord-015021-pol2qm74	3465	1	50	50	CD
cord-015021-pol2qm74	3465	2	pl	pl	NNS
cord-015021-pol2qm74	3465	3	of	of	IN
cord-015021-pol2qm74	3465	4	whole	whole	JJ
cord-015021-pol2qm74	3465	5	blood	blood	NN
cord-015021-pol2qm74	3465	6	were	be	VBD
cord-015021-pol2qm74	3465	7	incubated	incubate	VBN
cord-015021-pol2qm74	3465	8	with	with	IN
cord-015021-pol2qm74	3465	9	450	450	CD
cord-015021-pol2qm74	3465	10	pl	pl	NNP
cord-015021-pol2qm74	3465	11	RPMI	RPMI	NNP
cord-015021-pol2qm74	3465	12	-	-	HYPH
cord-015021-pol2qm74	3465	13	medium	medium	NN
cord-015021-pol2qm74	3465	14	supplemented	supplement	VBN
cord-015021-pol2qm74	3465	15	with	with	IN
cord-015021-pol2qm74	3465	16	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	3465	17	and	and	CC
cord-015021-pol2qm74	3465	18	L	L	NNP
cord-015021-pol2qm74	3465	19	-	-	HYPH
cord-015021-pol2qm74	3465	20	Glutamlne	Glutamlne	NNP
cord-015021-pol2qm74	3465	21	or	or	CC
cord-015021-pol2qm74	3465	22	with	with	IN
cord-015021-pol2qm74	3465	23	400	400	CD
cord-015021-pol2qm74	3465	24	pl	pl	NNS
cord-015021-pol2qm74	3465	25	of	of	IN
cord-015021-pol2qm74	3465	26	RPMI	RPMI	NNP
cord-015021-pol2qm74	3465	27	-	-	HYPH
cord-015021-pol2qm74	3465	28	medium	medium	NN
cord-015021-pol2qm74	3465	29	and	and	CC
cord-015021-pol2qm74	3465	30	50	50	CD
cord-015021-pol2qm74	3465	31	pl	pl	NN
cord-015021-pol2qm74	3465	32	phytohemagglutinin	phytohemagglutinin	NN
cord-015021-pol2qm74	3465	33	(	(	-LRB-
cord-015021-pol2qm74	3465	34	PHA	PHA	NNP
cord-015021-pol2qm74	3465	35	)	)	-RRB-
cord-015021-pol2qm74	3465	36	a	a	DT
cord-015021-pol2qm74	3465	37	potent	potent	JJ
cord-015021-pol2qm74	3465	38	mitogen	mitogen	NN
cord-015021-pol2qm74	3465	39	.	.	.
cord-015021-pol2qm74	3466	1	After	after	IN
cord-015021-pol2qm74	3466	2	an	an	DT
cord-015021-pol2qm74	3466	3	incubation	incubation	NN
cord-015021-pol2qm74	3466	4	period	period	NN
cord-015021-pol2qm74	3466	5	of	of	IN
cord-015021-pol2qm74	3466	6	24	24	CD
cord-015021-pol2qm74	3466	7	hours	hour	NNS
cord-015021-pol2qm74	3466	8	samples	sample	NNS
cord-015021-pol2qm74	3466	9	were	be	VBD
cord-015021-pol2qm74	3466	10	centrifuged	centrifuge	VBN
cord-015021-pol2qm74	3466	11	and	and	CC
cord-015021-pol2qm74	3466	12	plasma	plasma	NN
cord-015021-pol2qm74	3466	13	was	be	VBD
cord-015021-pol2qm74	3466	14	harvested	harvest	VBN
cord-015021-pol2qm74	3466	15	and	and	CC
cord-015021-pol2qm74	3466	16	stored	store	VBN
cord-015021-pol2qm74	3466	17	at	at	IN
cord-015021-pol2qm74	3466	18	-30	-30	CD
cord-015021-pol2qm74	3466	19	°	°	NN
cord-015021-pol2qm74	3466	20	celsius	celsiu	NNS
cord-015021-pol2qm74	3466	21	before	before	IN
cord-015021-pol2qm74	3466	22	assessment	assessment	NN
cord-015021-pol2qm74	3466	23	of	of	IN
cord-015021-pol2qm74	3466	24	TNF	TNF	NNP
cord-015021-pol2qm74	3466	25	-	-	:
cord-015021-pol2qm74	3466	26	a	a	DT
cord-015021-pol2qm74	3466	27	concentration	concentration	NN
cord-015021-pol2qm74	3466	28	by	by	IN
cord-015021-pol2qm74	3466	29	ELISA	ELISA	NNP
cord-015021-pol2qm74	3466	30	.	.	.
cord-015021-pol2qm74	3467	1	Statistical	statistical	JJ
cord-015021-pol2qm74	3467	2	analysis	analysis	NN
cord-015021-pol2qm74	3467	3	was	be	VBD
cord-015021-pol2qm74	3467	4	performed	perform	VBN
cord-015021-pol2qm74	3467	5	with	with	IN
cord-015021-pol2qm74	3467	6	the	the	DT
cord-015021-pol2qm74	3467	7	paired	pair	VBN
cord-015021-pol2qm74	3467	8	Student	Student	NNP
cord-015021-pol2qm74	3467	9	-	-	HYPH
cord-015021-pol2qm74	3467	10	T	T	NNP
cord-015021-pol2qm74	3467	11	-	-	HYPH
cord-015021-pol2qm74	3467	12	test	test	NN
cord-015021-pol2qm74	3467	13	.	.	.
cord-015021-pol2qm74	3468	1	Results	result	NNS
cord-015021-pol2qm74	3469	1	:	:	:
cord-015021-pol2qm74	3469	2	We	-PRON-	PRP
cord-015021-pol2qm74	3469	3	found	find	VBD
cord-015021-pol2qm74	3469	4	a	a	DT
cord-015021-pol2qm74	3469	5	significant	significant	JJ
cord-015021-pol2qm74	3469	6	difference	difference	NN
cord-015021-pol2qm74	3469	7	(	(	-LRB-
cord-015021-pol2qm74	3469	8	p	p	NN
cord-015021-pol2qm74	3469	9	<	<	XX
cord-015021-pol2qm74	3469	10	0,05	0,05	XX
cord-015021-pol2qm74	3469	11	)	)	-RRB-
cord-015021-pol2qm74	3469	12	for	for	IN
cord-015021-pol2qm74	3469	13	circulating	circulate	VBG
cord-015021-pol2qm74	3469	14	mean	mean	NN
cord-015021-pol2qm74	3470	1	arterial	arterial	JJ
cord-015021-pol2qm74	3470	2	TNF	TNF	NNP
cord-015021-pol2qm74	3470	3	-	-	:
cord-015021-pol2qm74	3470	4	a	a	DT
cord-015021-pol2qm74	3470	5	concentration	concentration	NN
cord-015021-pol2qm74	3471	1	(	(	-LRB-
cord-015021-pol2qm74	3471	2	237	237	CD
cord-015021-pol2qm74	3471	3	pg	pg	NNP
cord-015021-pol2qm74	3471	4	/	/	SYM
cord-015021-pol2qm74	3471	5	ml	ml	NN
cord-015021-pol2qm74	3471	6	_	_	NNP
cord-015021-pol2qm74	3471	7	+	+	SYM
cord-015021-pol2qm74	3471	8	34	34	CD
cord-015021-pol2qm74	3471	9	SEM	SEM	NNP
cord-015021-pol2qm74	3471	10	}	}	-RRB-
cord-015021-pol2qm74	3471	11	and	and	CC
cord-015021-pol2qm74	3471	12	central	central	JJ
cord-015021-pol2qm74	3471	13	venous	venous	JJ
cord-015021-pol2qm74	3471	14	TNF	TNF	NNP
cord-015021-pol2qm74	3471	15	-	-	,
cord-015021-pol2qm74	3471	16	a	a	DT
cord-015021-pol2qm74	3472	1	(	(	-LRB-
cord-015021-pol2qm74	3472	2	203	203	CD
cord-015021-pol2qm74	3472	3	pg	pg	NN
cord-015021-pol2qm74	3472	4	/	/	SYM
cord-015021-pol2qm74	3472	5	ml	ml	NN
cord-015021-pol2qm74	3472	6	+	+	CC
cord-015021-pol2qm74	3472	7	_	_	NN
cord-015021-pol2qm74	3472	8	29	29	CD
cord-015021-pol2qm74	3472	9	SEM	SEM	NNP
cord-015021-pol2qm74	3472	10	)	)	-RRB-
cord-015021-pol2qm74	3472	11	.	.	.
cord-015021-pol2qm74	3473	1	Upon	upon	IN
cord-015021-pol2qm74	3473	2	in	in	FW
cord-015021-pol2qm74	3473	3	vitro	vitro	FW
cord-015021-pol2qm74	3473	4	stimulation	stimulation	NN
cord-015021-pol2qm74	3473	5	there	there	EX
cord-015021-pol2qm74	3473	6	was	be	VBD
cord-015021-pol2qm74	3473	7	also	also	RB
cord-015021-pol2qm74	3473	8	a	a	DT
cord-015021-pol2qm74	3473	9	significant	significant	JJ
cord-015021-pol2qm74	3473	10	difference	difference	NN
cord-015021-pol2qm74	3473	11	(	(	-LRB-
cord-015021-pol2qm74	3473	12	p	p	NN
cord-015021-pol2qm74	3473	13	<	<	XX
cord-015021-pol2qm74	3473	14	0,002	0,002	CD
cord-015021-pol2qm74	3473	15	)	)	-RRB-
cord-015021-pol2qm74	3473	16	between	between	IN
cord-015021-pol2qm74	3473	17	released	release	VBN
cord-015021-pol2qm74	3473	18	arterial	arterial	JJ
cord-015021-pol2qm74	3473	19	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	3473	20	'	'	''
cord-015021-pol2qm74	3473	21	{	{	-LRB-
cord-015021-pol2qm74	3473	22	746	746	CD
cord-015021-pol2qm74	3473	23	pg	pg	NN
cord-015021-pol2qm74	3473	24	/	/	SYM
cord-015021-pol2qm74	3473	25	ml	ml	NN
cord-015021-pol2qm74	3473	26	_	_	NN
cord-015021-pol2qm74	3473	27	+	+	SYM
cord-015021-pol2qm74	3473	28	88	88	CD
cord-015021-pol2qm74	3473	29	SEM	SEM	NNP
cord-015021-pol2qm74	3473	30	)	)	-RRB-
cord-015021-pol2qm74	3473	31	and	and	CC
cord-015021-pol2qm74	3473	32	venous	venous	JJ
cord-015021-pol2qm74	3473	33	TNF	TNF	NNP
cord-015021-pol2qm74	3473	34	-	-	,
cord-015021-pol2qm74	3473	35	a	a	DT
cord-015021-pol2qm74	3474	1	(	(	-LRB-
cord-015021-pol2qm74	3474	2	637	637	CD
cord-015021-pol2qm74	3474	3	pg	pg	NN
cord-015021-pol2qm74	3474	4	/	/	SYM
cord-015021-pol2qm74	3474	5	ml	ml	NN
cord-015021-pol2qm74	3474	6	+	+	CC
cord-015021-pol2qm74	3475	1	_	_	NNP
cord-015021-pol2qm74	3475	2	76	76	CD
cord-015021-pol2qm74	3475	3	SEMI	semi	JJ
cord-015021-pol2qm74	3475	4	.	.	.
cord-015021-pol2qm74	3476	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3476	2	:	:	:
cord-015021-pol2qm74	3477	1	These	these	DT
cord-015021-pol2qm74	3477	2	results	result	NNS
cord-015021-pol2qm74	3477	3	are	be	VBP
cord-015021-pol2qm74	3477	4	difficult	difficult	JJ
cord-015021-pol2qm74	3477	5	to	to	TO
cord-015021-pol2qm74	3477	6	interprete	interprete	VB
cord-015021-pol2qm74	3477	7	but	but	CC
cord-015021-pol2qm74	3477	8	could	could	MD
cord-015021-pol2qm74	3477	9	reflect	reflect	VB
cord-015021-pol2qm74	3477	10	the	the	DT
cord-015021-pol2qm74	3477	11	influence	influence	NN
cord-015021-pol2qm74	3477	12	of	of	IN
cord-015021-pol2qm74	3477	13	paO	pao	JJ
cord-015021-pol2qm74	3477	14	2	2	CD
cord-015021-pol2qm74	3477	15	and	and	CC
cord-015021-pol2qm74	3477	16	SaO	SaO	NNP
cord-015021-pol2qm74	3477	17	2	2	CD
cord-015021-pol2qm74	3477	18	on	on	IN
cord-015021-pol2qm74	3477	19	TNF	TNF	NNP
cord-015021-pol2qm74	3477	20	a	a	DT
cord-015021-pol2qm74	3477	21	release	release	NN
cord-015021-pol2qm74	3477	22	.	.	.
cord-015021-pol2qm74	3478	1	It	-PRON-	PRP
cord-015021-pol2qm74	3478	2	could	could	MD
cord-015021-pol2qm74	3478	3	also	also	RB
cord-015021-pol2qm74	3478	4	be	be	VB
cord-015021-pol2qm74	3478	5	the	the	DT
cord-015021-pol2qm74	3478	6	result	result	NN
cord-015021-pol2qm74	3478	7	of	of	IN
cord-015021-pol2qm74	3478	8	different	different	JJ
cord-015021-pol2qm74	3478	9	concentrations	concentration	NNS
cord-015021-pol2qm74	3478	10	of	of	IN
cord-015021-pol2qm74	3478	11	TNF	TNF	NNP
cord-015021-pol2qm74	3478	12	-	-	HYPH
cord-015021-pol2qm74	3478	13	o	o	NN
cord-015021-pol2qm74	3478	14	release	release	NN
cord-015021-pol2qm74	3478	15	influencing	influencing	NN
cord-015021-pol2qm74	3478	16	factors	factor	NNS
cord-015021-pol2qm74	3478	17	like	like	IN
cord-015021-pol2qm74	3478	18	for	for	IN
cord-015021-pol2qm74	3478	19	example	example	NN
cord-015021-pol2qm74	3478	20	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3478	21	,	,	,
cord-015021-pol2qm74	3478	22	interferon	interferon	NN
cord-015021-pol2qm74	3478	23	-	-	HYPH
cord-015021-pol2qm74	3478	24	F	f	NN
cord-015021-pol2qm74	3478	25	or	or	CC
cord-015021-pol2qm74	3478	26	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	3478	27	.	.	.
cord-015021-pol2qm74	3479	1	A	a	DT
cord-015021-pol2qm74	3479	2	possible	possible	JJ
cord-015021-pol2qm74	3479	3	pulmonary	pulmonary	NN
cord-015021-pol2qm74	3479	4	and/or	and/or	CC
cord-015021-pol2qm74	3479	5	a	a	DT
cord-015021-pol2qm74	3479	6	hepatic	hepatic	JJ
cord-015021-pol2qm74	3479	7	metabolism	metabolism	NN
cord-015021-pol2qm74	3479	8	of	of	IN
cord-015021-pol2qm74	3479	9	TNF	TNF	NNP
cord-015021-pol2qm74	3479	10	-	-	HYPH
cord-015021-pol2qm74	3479	11	n	n	NNP
cord-015021-pol2qm74	3479	12	and	and	CC
cord-015021-pol2qm74	3479	13	TNF	TNF	NNP
cord-015021-pol2qm74	3479	14	-	-	:
cord-015021-pol2qm74	3479	15	a	a	DT
cord-015021-pol2qm74	3479	16	producing	produce	VBG
cord-015021-pol2qm74	3479	17	cells	cell	NNS
cord-015021-pol2qm74	3479	18	can	can	MD
cord-015021-pol2qm74	3479	19	not	not	RB
cord-015021-pol2qm74	3479	20	be	be	VB
cord-015021-pol2qm74	3479	21	ruled	rule	VBN
cord-015021-pol2qm74	3479	22	out	out	RP
cord-015021-pol2qm74	3479	23	.	.	.
cord-015021-pol2qm74	3480	1	However	however	RB
cord-015021-pol2qm74	3480	2	for	for	IN
cord-015021-pol2qm74	3480	3	better	well	JJR
cord-015021-pol2qm74	3480	4	interpretations	interpretation	NNS
cord-015021-pol2qm74	3480	5	of	of	IN
cord-015021-pol2qm74	3480	6	TNF	TNF	NNP
cord-015021-pol2qm74	3480	7	-	-	:
cord-015021-pol2qm74	3480	8	a	a	DT
cord-015021-pol2qm74	3480	9	release	release	NN
cord-015021-pol2qm74	3480	10	in	in	IN
cord-015021-pol2qm74	3480	11	septic	septic	JJ
cord-015021-pol2qm74	3480	12	states	state	NNS
cord-015021-pol2qm74	3480	13	it	-PRON-	PRP
cord-015021-pol2qm74	3480	14	is	be	VBZ
cord-015021-pol2qm74	3480	15	necessary	necessary	JJ
cord-015021-pol2qm74	3480	16	to	to	TO
cord-015021-pol2qm74	3480	17	use	use	VB
cord-015021-pol2qm74	3480	18	either	either	CC
cord-015021-pol2qm74	3480	19	arterial	arterial	JJ
cord-015021-pol2qm74	3480	20	or	or	CC
cord-015021-pol2qm74	3480	21	venous	venous	JJ
cord-015021-pol2qm74	3480	22	blood	blood	NN
cord-015021-pol2qm74	3480	23	samples	sample	NNS
cord-015021-pol2qm74	3480	24	.	.	.
cord-015021-pol2qm74	3481	1	Early	early	JJ
cord-015021-pol2qm74	3481	2	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3481	3	processes	process	NNS
cord-015021-pol2qm74	3481	4	following	follow	VBG
cord-015021-pol2qm74	3481	5	trauma	trauma	NN
cord-015021-pol2qm74	3482	1	and/or	and/or	CC
cord-015021-pol2qm74	3482	2	infections	infection	NNS
cord-015021-pol2qm74	3482	3	were	be	VBD
cord-015021-pol2qm74	3482	4	found	find	VBN
cord-015021-pol2qm74	3482	5	to	to	TO
cord-015021-pol2qm74	3482	6	be	be	VB
cord-015021-pol2qm74	3482	7	associated	associate	VBN
cord-015021-pol2qm74	3482	8	with	with	IN
cord-015021-pol2qm74	3482	9	the	the	DT
cord-015021-pol2qm74	3482	10	secretion	secretion	NN
cord-015021-pol2qm74	3482	11	of	of	IN
cord-015021-pol2qm74	3482	12	high	high	JJ
cord-015021-pol2qm74	3482	13	amounts	amount	NNS
cord-015021-pol2qm74	3482	14	of	of	IN
cord-015021-pol2qm74	3482	15	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3482	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	3482	17	.	.	.
cord-015021-pol2qm74	3483	1	Besides	besides	IN
cord-015021-pol2qm74	3483	2	intedeukin	intedeukin	NNP
cord-015021-pol2qm74	3483	3	-	-	HYPH
cord-015021-pol2qm74	3483	4	t	t	NNP
cord-015021-pol2qm74	3483	5	(	(	-LRB-
cord-015021-pol2qm74	3483	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	3483	7	)	)	-RRB-
cord-015021-pol2qm74	3483	8	,	,	,
cord-015021-pol2qm74	3483	9	tumor	tumor	NN
cord-015021-pol2qm74	3483	10	necrosis	necrosis	NN
cord-015021-pol2qm74	3483	11	factor	factor	NN
cord-015021-pol2qm74	3483	12	-	-	:
cord-015021-pol2qm74	3483	13	a	a	DT
cord-015021-pol2qm74	3483	14	(	(	-LRB-
cord-015021-pol2qm74	3483	15	TNF	TNF	NNP
cord-015021-pol2qm74	3483	16	-	-	HYPH
cord-015021-pol2qm74	3483	17	c	c	NN
cord-015021-pol2qm74	3483	18	0	0	CD
cord-015021-pol2qm74	3483	19	and	and	CC
cord-015021-pol2qm74	3483	20	interleukin-8	interleukin-8	NNP
cord-015021-pol2qm74	3483	21	(	(	-LRB-
cord-015021-pol2qm74	3483	22	IL-8	IL-8	NNP
cord-015021-pol2qm74	3483	23	)	)	-RRB-
cord-015021-pol2qm74	3483	24	the	the	DT
cord-015021-pol2qm74	3483	25	multifunctional	multifunctional	JJ
cord-015021-pol2qm74	3483	26	cytokine	cytokine	NN
cord-015021-pol2qm74	3483	27	intedeukin-6	intedeukin-6	NNP
cord-015021-pol2qm74	3483	28	(	(	-LRB-
cord-015021-pol2qm74	3483	29	IL-6	IL-6	NNP
cord-015021-pol2qm74	3483	30	)	)	-RRB-
cord-015021-pol2qm74	3483	31	was	be	VBD
cord-015021-pol2qm74	3483	32	described	describe	VBN
cord-015021-pol2qm74	3483	33	to	to	TO
cord-015021-pol2qm74	3483	34	be	be	VB
cord-015021-pol2qm74	3483	35	a	a	DT
cord-015021-pol2qm74	3483	36	central	central	JJ
cord-015021-pol2qm74	3483	37	regulatory	regulatory	JJ
cord-015021-pol2qm74	3483	38	element	element	NN
cord-015021-pol2qm74	3483	39	of	of	IN
cord-015021-pol2qm74	3483	40	the	the	DT
cord-015021-pol2qm74	3483	41	primary	primary	JJ
cord-015021-pol2qm74	3483	42	cellular	cellular	JJ
cord-015021-pol2qm74	3483	43	and	and	CC
cord-015021-pol2qm74	3483	44	humeral	humeral	JJ
cord-015021-pol2qm74	3483	45	defence	defence	NN
cord-015021-pol2qm74	3483	46	reaction	reaction	NN
cord-015021-pol2qm74	3483	47	.	.	.
cord-015021-pol2qm74	3484	1	The	the	DT
cord-015021-pol2qm74	3484	2	previously	previously	RB
cord-015021-pol2qm74	3484	3	described	describe	VBN
cord-015021-pol2qm74	3484	4	close	close	JJ
cord-015021-pol2qm74	3484	5	temporal	temporal	JJ
cord-015021-pol2qm74	3484	6	correlation	correlation	NN
cord-015021-pol2qm74	3484	7	of	of	IN
cord-015021-pol2qm74	3484	8	pathologically	pathologically	RB
cord-015021-pol2qm74	3484	9	elevated	elevated	JJ
cord-015021-pol2qm74	3484	10	IL-6-concentrations	il-6-concentration	NNS
cord-015021-pol2qm74	3484	11	and	and	CC
cord-015021-pol2qm74	3484	12	the	the	DT
cord-015021-pol2qm74	3484	13	extracellulary	extracellulary	JJ
cord-015021-pol2qm74	3484	14	release	release	NN
cord-015021-pol2qm74	3484	15	of	of	IN
cord-015021-pol2qm74	3484	16	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	3484	17	enzymes	enzyme	NNS
cord-015021-pol2qm74	3484	18	from	from	IN
cord-015021-pol2qm74	3484	19	activated	activate	VBN
cord-015021-pol2qm74	3484	20	pelymorphnuclear	pelymorphnuclear	NNP
cord-015021-pol2qm74	3484	21	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	3484	22	suggests	suggest	VBZ
cord-015021-pol2qm74	3484	23	,	,	,
cord-015021-pol2qm74	3484	24	that	that	IN
cord-015021-pol2qm74	3484	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	3484	26	may	may	MD
cord-015021-pol2qm74	3484	27	be	be	VB
cord-015021-pol2qm74	3484	28	a	a	DT
cord-015021-pol2qm74	3484	29	potential	potential	JJ
cord-015021-pol2qm74	3484	30	substrate	substrate	NN
cord-015021-pol2qm74	3484	31	of	of	IN
cord-015021-pol2qm74	3484	32	these	these	DT
cord-015021-pol2qm74	3484	33	preteases	pretease	NNS
cord-015021-pol2qm74	3484	34	.	.	.
cord-015021-pol2qm74	3485	1	The	the	DT
cord-015021-pol2qm74	3485	2	serine	serine	NN
cord-015021-pol2qm74	3485	3	preteases	pretease	NNS
cord-015021-pol2qm74	3485	4	elastase	elastase	NN
cord-015021-pol2qm74	3485	5	(	(	-LRB-
cord-015021-pol2qm74	3485	6	EC	EC	NNP
cord-015021-pol2qm74	3485	7	3.4.21.37	3.4.21.37	CD
cord-015021-pol2qm74	3485	8	)	)	-RRB-
cord-015021-pol2qm74	3485	9	and	and	CC
cord-015021-pol2qm74	3485	10	cathepsin	cathepsin	NN
cord-015021-pol2qm74	3485	11	G	g	NN
cord-015021-pol2qm74	3485	12	(	(	-LRB-
cord-015021-pol2qm74	3485	13	EC	EC	NNP
cord-015021-pol2qm74	3485	14	3.4.21.20	3.4.21.20	CD
cord-015021-pol2qm74	3485	15	)	)	-RRB-
cord-015021-pol2qm74	3485	16	derived	derive	VBN
cord-015021-pol2qm74	3485	17	from	from	IN
cord-015021-pol2qm74	3485	18	the	the	DT
cord-015021-pol2qm74	3485	19	azurophilic	azurophilic	JJ
cord-015021-pol2qm74	3485	20	granules	granule	NNS
cord-015021-pol2qm74	3485	21	were	be	VBD
cord-015021-pol2qm74	3485	22	assumed	assume	VBN
cord-015021-pol2qm74	3485	23	to	to	TO
cord-015021-pol2qm74	3485	24	be	be	VB
cord-015021-pol2qm74	3485	25	mainly	mainly	RB
cord-015021-pol2qm74	3485	26	involved	involve	VBN
cord-015021-pol2qm74	3485	27	in	in	IN
cord-015021-pol2qm74	3485	28	unspecific	unspecific	JJ
cord-015021-pol2qm74	3485	29	proteolysis	proteolysis	NN
cord-015021-pol2qm74	3485	30	at	at	IN
cord-015021-pol2qm74	3485	31	sites	site	NNS
cord-015021-pol2qm74	3485	32	of	of	IN
cord-015021-pol2qm74	3485	33	inflammation	inflammation	NN
cord-015021-pol2qm74	3485	34	by	by	IN
cord-015021-pol2qm74	3485	35	cleavage	cleavage	NN
cord-015021-pol2qm74	3485	36	of	of	IN
cord-015021-pol2qm74	3485	37	structural	structural	JJ
cord-015021-pol2qm74	3485	38	as	as	RB
cord-015021-pol2qm74	3485	39	well	well	RB
cord-015021-pol2qm74	3485	40	as	as	IN
cord-015021-pol2qm74	3485	41	soluble	soluble	JJ
cord-015021-pol2qm74	3485	42	proteins	protein	NNS
cord-015021-pol2qm74	3485	43	at	at	IN
cord-015021-pol2qm74	3485	44	random	random	JJ
cord-015021-pol2qm74	3485	45	sites	site	NNS
cord-015021-pol2qm74	3485	46	,	,	,
cord-015021-pol2qm74	3485	47	if	if	IN
cord-015021-pol2qm74	3485	48	the	the	DT
cord-015021-pol2qm74	3485	49	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	3485	50	potential	potential	NN
cord-015021-pol2qm74	3485	51	is	be	VBZ
cord-015021-pol2qm74	3485	52	decreased	decrease	VBN
cord-015021-pol2qm74	3485	53	.	.	.
cord-015021-pol2qm74	3486	1	The	the	DT
cord-015021-pol2qm74	3486	2	possible	possible	JJ
cord-015021-pol2qm74	3486	3	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	3486	4	activity	activity	NN
cord-015021-pol2qm74	3486	5	of	of	IN
cord-015021-pol2qm74	3486	6	elastase	elastase	NN
cord-015021-pol2qm74	3486	7	and	and	CC
cord-015021-pol2qm74	3486	8	cathepsin	cathepsin	NN
cord-015021-pol2qm74	3486	9	G	g	NN
cord-015021-pol2qm74	3486	10	toward	toward	IN
cord-015021-pol2qm74	3486	11	the	the	DT
cord-015021-pol2qm74	3486	12	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3486	13	cytokine	cytokine	NN
cord-015021-pol2qm74	3486	14	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	3487	1	(	(	-LRB-
cord-015021-pol2qm74	3487	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3487	3	)	)	-RRB-
cord-015021-pol2qm74	3487	4	was	be	VBD
cord-015021-pol2qm74	3487	5	investigated	investigate	VBN
cord-015021-pol2qm74	3487	6	.	.	.
cord-015021-pol2qm74	3488	1	The	the	DT
cord-015021-pol2qm74	3488	2	addition	addition	NN
cord-015021-pol2qm74	3488	3	of	of	IN
cord-015021-pol2qm74	3488	4	purified	purify	VBN
cord-015021-pol2qm74	3488	5	neutrephil	neutrephil	JJ
cord-015021-pol2qm74	3488	6	elastase	elastase	NN
cord-015021-pol2qm74	3488	7	and	and	CC
cord-015021-pol2qm74	3488	8	cathepsin	cathepsin	NN
cord-015021-pol2qm74	3488	9	G	g	NN
cord-015021-pol2qm74	3488	10	to	to	IN
cord-015021-pol2qm74	3488	11	recombinant	recombinant	JJ
cord-015021-pol2qm74	3488	12	human	human	NN
cord-015021-pol2qm74	3488	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	3488	14	leads	lead	VBZ
cord-015021-pol2qm74	3488	15	to	to	IN
cord-015021-pol2qm74	3488	16	a	a	DT
cord-015021-pol2qm74	3488	17	rapid	rapid	JJ
cord-015021-pol2qm74	3488	18	sequential	sequential	JJ
cord-015021-pol2qm74	3488	19	degradation	degradation	NN
cord-015021-pol2qm74	3488	20	in	in	IN
cord-015021-pol2qm74	3488	21	vitro	vitro	FW
cord-015021-pol2qm74	3488	22	.	.	.
cord-015021-pol2qm74	3489	1	At	at	RB
cord-015021-pol2qm74	3489	2	least	least	RBS
cord-015021-pol2qm74	3489	3	two	two	CD
cord-015021-pol2qm74	3489	4	intermediate	intermediate	JJ
cord-015021-pol2qm74	3489	5	products	product	NNS
cord-015021-pol2qm74	3489	6	could	could	MD
cord-015021-pol2qm74	3489	7	be	be	VB
cord-015021-pol2qm74	3489	8	detected	detect	VBN
cord-015021-pol2qm74	3489	9	by	by	IN
cord-015021-pol2qm74	3489	10	silver	silver	JJ
cord-015021-pol2qm74	3489	11	staining	staining	NN
cord-015021-pol2qm74	3489	12	and	and	CC
cord-015021-pol2qm74	3489	13	western	western	JJ
cord-015021-pol2qm74	3489	14	blotting	blotting	NN
cord-015021-pol2qm74	3489	15	following	follow	VBG
cord-015021-pol2qm74	3489	16	protein	protein	NN
cord-015021-pol2qm74	3489	17	separation	separation	NN
cord-015021-pol2qm74	3489	18	under	under	IN
cord-015021-pol2qm74	3489	19	reducing	reduce	VBG
cord-015021-pol2qm74	3489	20	conditions	condition	NNS
cord-015021-pol2qm74	3489	21	.	.	.
cord-015021-pol2qm74	3490	1	The	the	DT
cord-015021-pol2qm74	3490	2	serine	serine	JJ
cord-015021-pol2qm74	3490	3	protease	protease	NN
cord-015021-pol2qm74	3490	4	inhibitor	inhibitor	NN
cord-015021-pol2qm74	3490	5	G	G	NNP
cord-015021-pol2qm74	3490	6	-	-	HYPH
cord-015021-pol2qm74	3490	7	anitrypsin	anitrypsin	NNP
cord-015021-pol2qm74	3490	8	was	be	VBD
cord-015021-pol2qm74	3490	9	shown	show	VBN
cord-015021-pol2qm74	3490	10	to	to	TO
cord-015021-pol2qm74	3490	11	prevent	prevent	VB
cord-015021-pol2qm74	3490	12	the	the	DT
cord-015021-pol2qm74	3490	13	proteolytical	proteolytical	JJ
cord-015021-pol2qm74	3490	14	degradation	degradation	NN
cord-015021-pol2qm74	3490	15	of	of	IN
cord-015021-pol2qm74	3490	16	intedeukin-6	intedeukin-6	NNP
cord-015021-pol2qm74	3490	17	.	.	.
cord-015021-pol2qm74	3491	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	3491	2	the	the	DT
cord-015021-pol2qm74	3491	3	loss	loss	NN
cord-015021-pol2qm74	3491	4	of	of	IN
cord-015021-pol2qm74	3491	5	the	the	DT
cord-015021-pol2qm74	3491	6	biological	biological	JJ
cord-015021-pol2qm74	3491	7	activity	activity	NN
cord-015021-pol2qm74	3491	8	of	of	IN
cord-015021-pol2qm74	3491	9	both	both	DT
cord-015021-pol2qm74	3491	10	,	,	,
cord-015021-pol2qm74	3491	11	recombinant	recombinant	JJ
cord-015021-pol2qm74	3491	12	and	and	CC
cord-015021-pol2qm74	3491	13	natural	natural	JJ
cord-015021-pol2qm74	3491	14	human	human	JJ
cord-015021-pol2qm74	3491	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	3491	16	,	,	,
cord-015021-pol2qm74	3491	17	was	be	VBD
cord-015021-pol2qm74	3491	18	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3491	19	by	by	IN
cord-015021-pol2qm74	3491	20	determination	determination	NN
cord-015021-pol2qm74	3491	21	of	of	IN
cord-015021-pol2qm74	3491	22	the	the	DT
cord-015021-pol2qm74	3491	23	capacity	capacity	NN
cord-015021-pol2qm74	3491	24	of	of	IN
cord-015021-pol2qm74	3491	25	protease	protease	NN
cord-015021-pol2qm74	3491	26	-	-	HYPH
cord-015021-pol2qm74	3491	27	treated	treat	VBN
cord-015021-pol2qm74	3491	28	IL-6	IL-6	NNP
cord-015021-pol2qm74	3491	29	to	to	TO
cord-015021-pol2qm74	3491	30	stimulate	stimulate	VB
cord-015021-pol2qm74	3491	31	hybddoma	hybddoma	NNP
cord-015021-pol2qm74	3491	32	growth	growth	NN
cord-015021-pol2qm74	3491	33	(	(	-LRB-
cord-015021-pol2qm74	3491	34	7TD1	7td1	CD
cord-015021-pol2qm74	3491	35	bioassay	bioassay	NN
cord-015021-pol2qm74	3491	36	)	)	-RRB-
cord-015021-pol2qm74	3491	37	.	.	.
cord-015021-pol2qm74	3492	1	These	these	DT
cord-015021-pol2qm74	3492	2	data	datum	NNS
cord-015021-pol2qm74	3492	3	suggest	suggest	VBP
cord-015021-pol2qm74	3492	4	a	a	DT
cord-015021-pol2qm74	3492	5	possible	possible	JJ
cord-015021-pol2qm74	3492	6	downregulation	downregulation	NN
cord-015021-pol2qm74	3492	7	of	of	IN
cord-015021-pol2qm74	3492	8	pathologically	pathologically	RB
cord-015021-pol2qm74	3492	9	elevated	elevate	VBN
cord-015021-pol2qm74	3492	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	3492	11	levels	level	NNS
cord-015021-pol2qm74	3492	12	by	by	IN
cord-015021-pol2qm74	3492	13	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	3492	14	activity	activity	NN
cord-015021-pol2qm74	3492	15	of	of	IN
cord-015021-pol2qm74	3492	16	extracellulary	extracellulary	JJ
cord-015021-pol2qm74	3492	17	released	release	VBN
cord-015021-pol2qm74	3492	18	enzymes	enzyme	NNS
cord-015021-pol2qm74	3492	19	at	at	IN
cord-015021-pol2qm74	3492	20	sites	site	NNS
cord-015021-pol2qm74	3492	21	of	of	IN
cord-015021-pol2qm74	3492	22	inflammation	inflammation	NN
cord-015021-pol2qm74	3492	23	.	.	.
cord-015021-pol2qm74	3493	1	The	the	DT
cord-015021-pol2qm74	3493	2	aim	aim	NN
cord-015021-pol2qm74	3493	3	of	of	IN
cord-015021-pol2qm74	3493	4	the	the	DT
cord-015021-pol2qm74	3493	5	study	study	NN
cord-015021-pol2qm74	3493	6	was	be	VBD
cord-015021-pol2qm74	3493	7	to	to	TO
cord-015021-pol2qm74	3493	8	compare	compare	VB
cord-015021-pol2qm74	3493	9	circulating	circulate	VBG
cord-015021-pol2qm74	3493	10	levels	level	NNS
cord-015021-pol2qm74	3493	11	of	of	IN
cord-015021-pol2qm74	3493	12	three	three	CD
cord-015021-pol2qm74	3493	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	3493	14	-IL-1	-il-1	XX
cord-015021-pol2qm74	3493	15	,	,	,
cord-015021-pol2qm74	3493	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	3493	17	,	,	,
cord-015021-pol2qm74	3493	18	11_-8	11_-8	CD
cord-015021-pol2qm74	3493	19	-between	-between	SYM
cord-015021-pol2qm74	3493	20	critically	critically	RB
cord-015021-pol2qm74	3493	21	ill	ill	JJ
cord-015021-pol2qm74	3493	22	subjects	subject	NNS
cord-015021-pol2qm74	3493	23	who	who	WP
cord-015021-pol2qm74	3493	24	developed	develop	VBD
cord-015021-pol2qm74	3493	25	Gram	gram	NN
cord-015021-pol2qm74	3493	26	-	-	HYPH
cord-015021-pol2qm74	3493	27	negative	negative	JJ
cord-015021-pol2qm74	3493	28	sepsis	sepsis	NN
cord-015021-pol2qm74	3493	29	and	and	CC
cord-015021-pol2qm74	3493	30	who	who	WP
cord-015021-pol2qm74	3493	31	did	do	VBD
cord-015021-pol2qm74	3493	32	not	not	RB
cord-015021-pol2qm74	3493	33	.	.	.
cord-015021-pol2qm74	3494	1	MATERIALS	materials	NN
cord-015021-pol2qm74	3494	2	AND	and	CC
cord-015021-pol2qm74	3494	3	METHODS	method	NNS
cord-015021-pol2qm74	3494	4	:	:	:
cord-015021-pol2qm74	3495	1	The	the	DT
cord-015021-pol2qm74	3495	2	patient	patient	JJ
cord-015021-pol2qm74	3495	3	population	population	NN
cord-015021-pol2qm74	3495	4	consisted	consist	VBD
cord-015021-pol2qm74	3495	5	of	of	IN
cord-015021-pol2qm74	3495	6	39	39	CD
cord-015021-pol2qm74	3495	7	patients	patient	NNS
cord-015021-pol2qm74	3495	8	admitted	admit	VBN
cord-015021-pol2qm74	3495	9	to	to	IN
cord-015021-pol2qm74	3495	10	an	an	DT
cord-015021-pol2qm74	3495	11	Intensive	Intensive	NNP
cord-015021-pol2qm74	3495	12	Cars	Cars	NNPS
cord-015021-pol2qm74	3495	13	Unit	Unit	NNP
cord-015021-pol2qm74	3495	14	,	,	,
cord-015021-pol2qm74	3495	15	with	with	IN
cord-015021-pol2qm74	3495	16	different	different	JJ
cord-015021-pol2qm74	3495	17	underlying	underlie	VBG
cord-015021-pol2qm74	3495	18	diseases	disease	NNS
cord-015021-pol2qm74	3495	19	.	.	.
cord-015021-pol2qm74	3496	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	3496	2	diagnosis	diagnosis	NN
cord-015021-pol2qm74	3496	3	was	be	VBD
cord-015021-pol2qm74	3496	4	given	give	VBN
cord-015021-pol2qm74	3496	5	according	accord	VBG
cord-015021-pol2qm74	3496	6	to	to	IN
cord-015021-pol2qm74	3496	7	pre	pre	JJ
cord-015021-pol2qm74	3496	8	-	-	JJ
cord-015021-pol2qm74	3496	9	estabilished	estabilished	JJ
cord-015021-pol2qm74	3496	10	cdteda	cdteda	NN
cord-015021-pol2qm74	3496	11	.	.	.
cord-015021-pol2qm74	3497	1	Nineteen	nineteen	CD
cord-015021-pol2qm74	3497	2	cases	case	NNS
cord-015021-pol2qm74	3497	3	were	be	VBD
cord-015021-pol2qm74	3497	4	enrolled	enrol	VBN
cord-015021-pol2qm74	3497	5	in	in	IN
cord-015021-pol2qm74	3497	6	sepsis	sepsis	NN
cord-015021-pol2qm74	3497	7	group	group	NN
cord-015021-pol2qm74	3497	8	,	,	,
cord-015021-pol2qm74	3497	9	twenty	twenty	CD
cord-015021-pol2qm74	3497	10	in	in	IN
cord-015021-pol2qm74	3497	11	control	control	NN
cord-015021-pol2qm74	3497	12	group	group	NN
cord-015021-pol2qm74	3497	13	.	.	.
cord-015021-pol2qm74	3498	1	Serum	serum	NN
cord-015021-pol2qm74	3498	2	sampling	sampling	NN
cord-015021-pol2qm74	3498	3	was	be	VBD
cord-015021-pol2qm74	3498	4	collected	collect	VBN
cord-015021-pol2qm74	3498	5	in	in	IN
cord-015021-pol2qm74	3498	6	sterile	sterile	JJ
cord-015021-pol2qm74	3498	7	tubes	tube	NNS
cord-015021-pol2qm74	3498	8	at	at	IN
cord-015021-pol2qm74	3498	9	study	study	NN
cord-015021-pol2qm74	3498	10	entry	entry	NN
cord-015021-pol2qm74	3498	11	and	and	CC
cord-015021-pol2qm74	3498	12	every	every	DT
cord-015021-pol2qm74	3498	13	three	three	CD
cord-015021-pol2qm74	3498	14	days	day	NNS
cord-015021-pol2qm74	3498	15	until	until	IN
cord-015021-pol2qm74	3498	16	study	study	NN
cord-015021-pol2qm74	3498	17	dismissal	dismissal	NN
cord-015021-pol2qm74	3498	18	.	.	.
cord-015021-pol2qm74	3499	1	Serum	serum	NN
cord-015021-pol2qm74	3499	2	concentrations	concentration	NNS
cord-015021-pol2qm74	3499	3	of	of	IN
cord-015021-pol2qm74	3500	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	3500	2	,	,	,
cord-015021-pol2qm74	3500	3	11_-6	11_-6	CD
cord-015021-pol2qm74	3500	4	and	and	CC
cord-015021-pol2qm74	3500	5	IL-8	IL-8	NNP
cord-015021-pol2qm74	3500	6	were	be	VBD
cord-015021-pol2qm74	3500	7	measured	measure	VBN
cord-015021-pol2qm74	3500	8	using	use	VBG
cord-015021-pol2qm74	3500	9	commercially	commercially	RB
cord-015021-pol2qm74	3500	10	available	available	JJ
cord-015021-pol2qm74	3500	11	test	test	NN
cord-015021-pol2qm74	3500	12	kits	kit	NNS
cord-015021-pol2qm74	3500	13	,	,	,
cord-015021-pol2qm74	3500	14	based	base	VBN
cord-015021-pol2qm74	3500	15	on	on	IN
cord-015021-pol2qm74	3500	16	the	the	DT
cord-015021-pol2qm74	3500	17	dual	dual	JJ
cord-015021-pol2qm74	3500	18	immunometric	immunometric	NNP
cord-015021-pol2qm74	3500	19	sandwich	sandwich	NN
cord-015021-pol2qm74	3500	20	principle	principle	NN
cord-015021-pol2qm74	3500	21	.	.	.
cord-015021-pol2qm74	3501	1	RESULTS	result	NNS
cord-015021-pol2qm74	3501	2	:	:	:
cord-015021-pol2qm74	3502	1	The	the	DT
cord-015021-pol2qm74	3502	2	causative	causative	JJ
cord-015021-pol2qm74	3502	3	patogens	patogen	NNS
cord-015021-pol2qm74	3502	4	of	of	IN
cord-015021-pol2qm74	3502	5	sepsis	sepsis	NN
cord-015021-pol2qm74	3502	6	were	be	VBD
cord-015021-pol2qm74	3502	7	:	:	:
cord-015021-pol2qm74	3502	8	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	3502	9	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	3502	10	,	,	,
cord-015021-pol2qm74	3502	11	Acinetobacter	Acinetobacter	NNP
cord-015021-pol2qm74	3502	12	,	,	,
cord-015021-pol2qm74	3503	1	Eseherichia	Eseherichia	NNP
cord-015021-pol2qm74	3503	2	co	co	VBD
cord-015021-pol2qm74	3503	3	~	~	NNP
cord-015021-pol2qm74	3503	4	i	i	PRP
cord-015021-pol2qm74	3503	5	,	,	,
cord-015021-pol2qm74	3503	6	Serratia	Serratia	NNP
cord-015021-pol2qm74	3503	7	marceseens	marceseen	NNS
cord-015021-pol2qm74	3503	8	,	,	,
cord-015021-pol2qm74	3503	9	Proteus	Proteus	NNP
cord-015021-pol2qm74	3503	10	mirobilis	mirobilis	NNP
cord-015021-pol2qm74	3503	11	and	and	CC
cord-015021-pol2qm74	3503	12	Citrobacter	Citrobacter	NNP
cord-015021-pol2qm74	3503	13	freundL	freundL	NNP
cord-015021-pol2qm74	3504	1	The	the	DT
cord-015021-pol2qm74	3504	2	time	time	NN
cord-015021-pol2qm74	3504	3	of	of	IN
cord-015021-pol2qm74	3504	4	observation	observation	NN
cord-015021-pol2qm74	3504	5	was	be	VBD
cord-015021-pol2qm74	3504	6	equal	equal	JJ
cord-015021-pol2qm74	3504	7	to	to	IN
cord-015021-pol2qm74	3504	8	12	12	CD
cord-015021-pol2qm74	3504	9	days	day	NNS
cord-015021-pol2qm74	3504	10	,	,	,
cord-015021-pol2qm74	3504	11	for	for	IN
cord-015021-pol2qm74	3504	12	a	a	DT
cord-015021-pol2qm74	3504	13	total	total	NN
cord-015021-pol2qm74	3504	14	of	of	IN
cord-015021-pol2qm74	3504	15	four	four	CD
cord-015021-pol2qm74	3504	16	tests	test	NNS
cord-015021-pol2qm74	3504	17	performed	perform	VBN
cord-015021-pol2qm74	3504	18	(	(	-LRB-
cord-015021-pol2qm74	3504	19	to	to	TO
cord-015021-pol2qm74	3504	20	,	,	,
cord-015021-pol2qm74	3504	21	tl	tl	NNP
cord-015021-pol2qm74	3504	22	,	,	,
cord-015021-pol2qm74	3504	23	t2	t2	NNP
cord-015021-pol2qm74	3504	24	,	,	,
cord-015021-pol2qm74	3504	25	t3	t3	NNP
cord-015021-pol2qm74	3504	26	)	)	-RRB-
cord-015021-pol2qm74	3504	27	.	.	.
cord-015021-pol2qm74	3505	1	I1.-1	I1.-1	NNP
cord-015021-pol2qm74	3505	2	was	be	VBD
cord-015021-pol2qm74	3505	3	not	not	RB
cord-015021-pol2qm74	3505	4	detected	detect	VBN
cord-015021-pol2qm74	3505	5	in	in	IN
cord-015021-pol2qm74	3505	6	any	any	DT
cord-015021-pol2qm74	3505	7	samples	sample	NNS
cord-015021-pol2qm74	3505	8	.	.	.
cord-015021-pol2qm74	3506	1	The	the	DT
cord-015021-pol2qm74	3506	2	serological	serological	JJ
cord-015021-pol2qm74	3506	3	profiles	profile	NNS
cord-015021-pol2qm74	3506	4	of	of	IN
cord-015021-pol2qm74	3506	5	the	the	DT
cord-015021-pol2qm74	3506	6	two	two	CD
cord-015021-pol2qm74	3506	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	3506	8	11.-6	11.-6	CD
cord-015021-pol2qm74	3506	9	and	and	CC
cord-015021-pol2qm74	3506	10	11_-8	11_-8	CD
cord-015021-pol2qm74	3506	11	were	be	VBD
cord-015021-pol2qm74	3506	12	similar	similar	JJ
cord-015021-pol2qm74	3506	13	;	;	:
cord-015021-pol2qm74	3506	14	augmented	augment	VBN
cord-015021-pol2qm74	3506	15	levels	level	NNS
cord-015021-pol2qm74	3506	16	were	be	VBD
cord-015021-pol2qm74	3506	17	found	find	VBN
cord-015021-pol2qm74	3506	18	at	at	IN
cord-015021-pol2qm74	3506	19	study	study	NN
cord-015021-pol2qm74	3506	20	entry	entry	NN
cord-015021-pol2qm74	3506	21	and	and	CC
cord-015021-pol2qm74	3506	22	throughout	throughout	IN
cord-015021-pol2qm74	3506	23	the	the	DT
cord-015021-pol2qm74	3506	24	observation	observation	NN
cord-015021-pol2qm74	3506	25	period	period	NN
cord-015021-pol2qm74	3506	26	,	,	,
cord-015021-pol2qm74	3506	27	peaking	peak	VBG
cord-015021-pol2qm74	3506	28	at	at	IN
cord-015021-pol2qm74	3506	29	t3	t3	NNP
cord-015021-pol2qm74	3506	30	and	and	CC
cord-015021-pol2qm74	3506	31	decreasing	decrease	VBG
cord-015021-pol2qm74	3506	32	at	at	IN
cord-015021-pol2qm74	3506	33	t4	t4	NNP
cord-015021-pol2qm74	3506	34	.	.	.
cord-015021-pol2qm74	3507	1	However	however	RB
cord-015021-pol2qm74	3507	2	,	,	,
cord-015021-pol2qm74	3507	3	in	in	IN
cord-015021-pol2qm74	3507	4	patients	patient	NNS
cord-015021-pol2qm74	3507	5	with	with	IN
cord-015021-pol2qm74	3507	6	sepsis	sepsis	NN
cord-015021-pol2qm74	3507	7	,	,	,
cord-015021-pol2qm74	3507	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	3507	9	and	and	CC
cord-015021-pol2qm74	3507	10	11_-8	11_-8	CD
cord-015021-pol2qm74	3507	11	concentrations	concentration	NNS
cord-015021-pol2qm74	3507	12	were	be	VBD
cord-015021-pol2qm74	3507	13	significantly	significantly	RB
cord-015021-pol2qm74	3507	14	higher	high	JJR
cord-015021-pol2qm74	3507	15	in	in	IN
cord-015021-pol2qm74	3507	16	respect	respect	NN
cord-015021-pol2qm74	3507	17	to	to	IN
cord-015021-pol2qm74	3507	18	control	control	NN
cord-015021-pol2qm74	3507	19	group	group	NN
cord-015021-pol2qm74	3507	20	.	.	.
cord-015021-pol2qm74	3508	1	CONCLUSION	conclusion	NN
cord-015021-pol2qm74	3508	2	:	:	:
cord-015021-pol2qm74	3509	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3509	2	observations	observation	NNS
cord-015021-pol2qm74	3509	3	shown	show	VBN
cord-015021-pol2qm74	3509	4	that	that	IN
cord-015021-pol2qm74	3509	5	in	in	IN
cord-015021-pol2qm74	3509	6	ICU	ICU	NNP
cord-015021-pol2qm74	3509	7	patients	patient	NNS
cord-015021-pol2qm74	3509	8	increased	increase	VBD
cord-015021-pol2qm74	3509	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	3509	10	and	and	CC
cord-015021-pol2qm74	3509	11	IL-8	IL-8	NNP
cord-015021-pol2qm74	3509	12	release	release	NN
cord-015021-pol2qm74	3509	13	may	may	MD
cord-015021-pol2qm74	3509	14	be	be	VB
cord-015021-pol2qm74	3509	15	induced	induce	VBN
cord-015021-pol2qm74	3509	16	by	by	IN
cord-015021-pol2qm74	3509	17	cdtical	cdtical	JJ
cord-015021-pol2qm74	3509	18	illness	illness	NN
cord-015021-pol2qm74	3509	19	;	;	:
cord-015021-pol2qm74	3509	20	however	however	RB
cord-015021-pol2qm74	3509	21	,	,	,
cord-015021-pol2qm74	3509	22	in	in	IN
cord-015021-pol2qm74	3509	23	subjects	subject	NNS
cord-015021-pol2qm74	3509	24	in	in	IN
cord-015021-pol2qm74	3509	25	which	which	WDT
cord-015021-pol2qm74	3509	26	sepsis	sepsis	NN
cord-015021-pol2qm74	3509	27	occurred	occur	VBD
cord-015021-pol2qm74	3509	28	,	,	,
cord-015021-pol2qm74	3509	29	IL-6	IL-6	NNP
cord-015021-pol2qm74	3509	30	and	and	CC
cord-015021-pol2qm74	3509	31	IL-8	IL-8	NNP
cord-015021-pol2qm74	3509	32	production	production	NN
cord-015021-pol2qm74	3509	33	appears	appear	VBZ
cord-015021-pol2qm74	3509	34	more	more	RBR
cord-015021-pol2qm74	3509	35	significantly	significantly	RB
cord-015021-pol2qm74	3509	36	elevated	elevate	VBN
cord-015021-pol2qm74	3509	37	,	,	,
cord-015021-pol2qm74	3509	38	suggesting	suggest	VBG
cord-015021-pol2qm74	3509	39	a	a	DT
cord-015021-pol2qm74	3509	40	role	role	NN
cord-015021-pol2qm74	3509	41	of	of	IN
cord-015021-pol2qm74	3509	42	IL-6	IL-6	NNP
cord-015021-pol2qm74	3509	43	and	and	CC
cord-015021-pol2qm74	3509	44	11_-8	11_-8	CD
cord-015021-pol2qm74	3509	45	in	in	IN
cord-015021-pol2qm74	3509	46	the	the	DT
cord-015021-pol2qm74	3509	47	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	3509	48	of	of	IN
cord-015021-pol2qm74	3509	49	sepsis	sepsis	NN
cord-015021-pol2qm74	3509	50	.	.	.
cord-015021-pol2qm74	3510	1	The	the	DT
cord-015021-pol2qm74	3510	2	fact	fact	NN
cord-015021-pol2qm74	3510	3	that	that	IN
cord-015021-pol2qm74	3510	4	II	II	NNP
cord-015021-pol2qm74	3510	5	.	.	.
cord-015021-pol2qm74	3511	1	Objective	objective	NN
cord-015021-pol2qm74	3511	2	:	:	:
cord-015021-pol2qm74	3511	3	To	to	TO
cord-015021-pol2qm74	3511	4	check	check	VB
cord-015021-pol2qm74	3511	5	whether	whether	IN
cord-015021-pol2qm74	3511	6	continuous	continuous	JJ
cord-015021-pol2qm74	3511	7	veno	veno	NNP
cord-015021-pol2qm74	3511	8	-	-	HYPH
cord-015021-pol2qm74	3511	9	venous	venous	JJ
cord-015021-pol2qm74	3511	10	haemofiltration	haemofiltration	NNP
cord-015021-pol2qm74	3511	11	(	(	-LRB-
cord-015021-pol2qm74	3511	12	CVVH	CVVH	NNP
cord-015021-pol2qm74	3511	13	)	)	-RRB-
cord-015021-pol2qm74	3511	14	could	could	MD
cord-015021-pol2qm74	3511	15	remove	remove	VB
cord-015021-pol2qm74	3511	16	the	the	DT
cord-015021-pol2qm74	3511	17	cytokines	cytokine	NNS
cord-015021-pol2qm74	3511	18	,	,	,
cord-015021-pol2qm74	3511	19	namely	namely	RB
cord-015021-pol2qm74	3511	20	tumour	tumour	NN
cord-015021-pol2qm74	3511	21	necrosis	necrosis	NN
cord-015021-pol2qm74	3511	22	factor	factor	NN
cord-015021-pol2qm74	3511	23	alpha	alpha	NN
cord-015021-pol2qm74	3511	24	(	(	-LRB-
cord-015021-pol2qm74	3511	25	TNFc	TNFc	NNP
cord-015021-pol2qm74	3511	26	0	0	NFP
cord-015021-pol2qm74	3511	27	and	and	CC
cord-015021-pol2qm74	3511	28	interleukin	interleukin	NN
cord-015021-pol2qm74	3511	29	6	6	CD
cord-015021-pol2qm74	3511	30	(	(	-LRB-
cord-015021-pol2qm74	3511	31	IL-6	IL-6	NNP
cord-015021-pol2qm74	3511	32	)	)	-RRB-
cord-015021-pol2qm74	3511	33	from	from	IN
cord-015021-pol2qm74	3511	34	the	the	DT
cord-015021-pol2qm74	3511	35	circulation	circulation	NN
cord-015021-pol2qm74	3511	36	of	of	IN
cord-015021-pol2qm74	3511	37	critically	critically	RB
cord-015021-pol2qm74	3511	38	ill	ill	JJ
cord-015021-pol2qm74	3511	39	patients	patient	NNS
cord-015021-pol2qm74	3511	40	with	with	IN
cord-015021-pol2qm74	3511	41	sepsis	sepsis	NN
cord-015021-pol2qm74	3511	42	ad	ad	NN
cord-015021-pol2qm74	3511	43	multiple	multiple	JJ
cord-015021-pol2qm74	3511	44	organ	organ	NN
cord-015021-pol2qm74	3511	45	failure	failure	NN
cord-015021-pol2qm74	3511	46	(	(	-LRB-
cord-015021-pol2qm74	3511	47	MOF	MOF	NNP
cord-015021-pol2qm74	3511	48	)	)	-RRB-
cord-015021-pol2qm74	3511	49	.	.	.
cord-015021-pol2qm74	3512	1	Setting	set	VBG
cord-015021-pol2qm74	3512	2	:	:	:
cord-015021-pol2qm74	3512	3	The	the	DT
cord-015021-pol2qm74	3512	4	intensive	intensive	JJ
cord-015021-pol2qm74	3512	5	therapy	therapy	NN
cord-015021-pol2qm74	3512	6	unit	unit	NN
cord-015021-pol2qm74	3512	7	of	of	IN
cord-015021-pol2qm74	3512	8	the	the	DT
cord-015021-pol2qm74	3512	9	medical	medical	JJ
cord-015021-pol2qm74	3512	10	school	school	NN
cord-015021-pol2qm74	3512	11	teaching	teaching	NN
cord-015021-pol2qm74	3512	12	hospital	hospital	NN
cord-015021-pol2qm74	3512	13	.	.	.
cord-015021-pol2qm74	3513	1	Patients	patient	NNS
cord-015021-pol2qm74	3513	2	:	:	:
cord-015021-pol2qm74	3514	1	Nine	nine	CD
cord-015021-pol2qm74	3514	2	critically	critically	RB
cord-015021-pol2qm74	3514	3	ill	ill	JJ
cord-015021-pol2qm74	3514	4	patients	patient	NNS
cord-015021-pol2qm74	3514	5	with	with	IN
cord-015021-pol2qm74	3514	6	sepsis	sepsis	NN
cord-015021-pol2qm74	3514	7	and	and	CC
cord-015021-pol2qm74	3514	8	MOF	MOF	NNP
cord-015021-pol2qm74	3514	9	treated	treat	VBN
cord-015021-pol2qm74	3514	10	with	with	IN
cord-015021-pol2qm74	3514	11	CVVH	CVVH	NNP
cord-015021-pol2qm74	3514	12	.	.	.
cord-015021-pol2qm74	3515	1	Methods	method	NNS
cord-015021-pol2qm74	3515	2	:	:	:
cord-015021-pol2qm74	3515	3	Blood	blood	NN
cord-015021-pol2qm74	3515	4	samples	sample	NNS
cord-015021-pol2qm74	3515	5	were	be	VBD
cord-015021-pol2qm74	3515	6	collected	collect	VBN
cord-015021-pol2qm74	3515	7	before	before	IN
cord-015021-pol2qm74	3515	8	the	the	DT
cord-015021-pol2qm74	3515	9	CVVH	CVVH	NNP
cord-015021-pol2qm74	3515	10	had	have	VBD
cord-015021-pol2qm74	3515	11	been	be	VBN
cord-015021-pol2qm74	3515	12	started	start	VBN
cord-015021-pol2qm74	3515	13	.	.	.
cord-015021-pol2qm74	3516	1	Then	then	RB
cord-015021-pol2qm74	3516	2	,	,	,
cord-015021-pol2qm74	3516	3	blood	blood	NN
cord-015021-pol2qm74	3516	4	and	and	CC
cord-015021-pol2qm74	3516	5	Ultrafiltrate	Ultrafiltrate	NNP
cord-015021-pol2qm74	3516	6	samples	sample	NNS
cord-015021-pol2qm74	3516	7	were	be	VBD
cord-015021-pol2qm74	3516	8	collected	collect	VBN
cord-015021-pol2qm74	3516	9	simultaneously	simultaneously	RB
cord-015021-pol2qm74	3516	10	after	after	IN
cord-015021-pol2qm74	3516	11	4	4	CD
cord-015021-pol2qm74	3516	12	hours	hour	NNS
cord-015021-pol2qm74	3516	13	and	and	CC
cord-015021-pol2qm74	3516	14	every	every	DT
cord-015021-pol2qm74	3516	15	24	24	CD
cord-015021-pol2qm74	3516	16	hour	hour	NN
cord-015021-pol2qm74	3516	17	.	.	.
cord-015021-pol2qm74	3517	1	TNFct	TNFct	NNP
cord-015021-pol2qm74	3517	2	and	and	CC
cord-015021-pol2qm74	3517	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	3517	4	levels	level	NNS
cord-015021-pol2qm74	3517	5	were	be	VBD
cord-015021-pol2qm74	3517	6	measured	measure	VBN
cord-015021-pol2qm74	3517	7	using	use	VBG
cord-015021-pol2qm74	3517	8	the	the	DT
cord-015021-pol2qm74	3517	9	bioassays	bioassay	NNS
cord-015021-pol2qm74	3517	10	with	with	IN
cord-015021-pol2qm74	3517	11	cell	cell	NN
cord-015021-pol2qm74	3517	12	lines	line	NNS
cord-015021-pol2qm74	3517	13	WEHI-164	WEHI-164	NNP
cord-015021-pol2qm74	3517	14	ci13	ci13	NNP
cord-015021-pol2qm74	3517	15	and	and	CC
cord-015021-pol2qm74	3517	16	7TD1	7td1	CD
cord-015021-pol2qm74	3517	17	,	,	,
cord-015021-pol2qm74	3517	18	respectively	respectively	RB
cord-015021-pol2qm74	3517	19	.	.	.
cord-015021-pol2qm74	3518	1	Other	other	JJ
cord-015021-pol2qm74	3518	2	data	datum	NNS
cord-015021-pol2qm74	3518	3	were	be	VBD
cord-015021-pol2qm74	3518	4	recorded	record	VBN
cord-015021-pol2qm74	3518	5	from	from	IN
cord-015021-pol2qm74	3518	6	the	the	DT
cord-015021-pol2qm74	3518	7	patient	patient	NN
cord-015021-pol2qm74	3518	8	notes	note	NNS
cord-015021-pol2qm74	3518	9	and	and	CC
cord-015021-pol2qm74	3518	10	intensive	intensive	JJ
cord-015021-pol2qm74	3518	11	therapy	therapy	NN
cord-015021-pol2qm74	3518	12	unit	unit	NN
cord-015021-pol2qm74	3518	13	charts	chart	NNS
cord-015021-pol2qm74	3518	14	.	.	.
cord-015021-pol2qm74	3519	1	Results	result	NNS
cord-015021-pol2qm74	3519	2	:	:	:
cord-015021-pol2qm74	3520	1	No	no	DT
cord-015021-pol2qm74	3520	2	measurable	measurable	JJ
cord-015021-pol2qm74	3520	3	concentrations	concentration	NNS
cord-015021-pol2qm74	3520	4	of	of	IN
cord-015021-pol2qm74	3520	5	TNFct	TNFct	NNP
cord-015021-pol2qm74	3520	6	were	be	VBD
cord-015021-pol2qm74	3520	7	detected	detect	VBN
cord-015021-pol2qm74	3520	8	in	in	IN
cord-015021-pol2qm74	3520	9	either	either	CC
cord-015021-pol2qm74	3520	10	blood	blood	NN
cord-015021-pol2qm74	3520	11	or	or	CC
cord-015021-pol2qm74	3520	12	ultrafiltrate	ultrafiltrate	JJ
cord-015021-pol2qm74	3520	13	samples	sample	NNS
cord-015021-pol2qm74	3520	14	.	.	.
cord-015021-pol2qm74	3521	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3521	2	was	be	VBD
cord-015021-pol2qm74	3521	3	found	find	VBN
cord-015021-pol2qm74	3521	4	in	in	IN
cord-015021-pol2qm74	3521	5	all	all	PDT
cord-015021-pol2qm74	3521	6	the	the	DT
cord-015021-pol2qm74	3521	7	patients	patient	NNS
cord-015021-pol2qm74	3521	8	'	'	POS
cord-015021-pol2qm74	3521	9	plasma	plasma	NN
cord-015021-pol2qm74	3521	10	samples	sample	NNS
cord-015021-pol2qm74	3521	11	and	and	CC
cord-015021-pol2qm74	3521	12	five	five	CD
cord-015021-pol2qm74	3521	13	patients	patient	NNS
cord-015021-pol2qm74	3521	14	'	'	''
cord-015021-pol2qm74	3521	15	(	(	-LRB-
cord-015021-pol2qm74	3521	16	55.5	55.5	CD
cord-015021-pol2qm74	3521	17	%	%	NN
cord-015021-pol2qm74	3521	18	)	)	-RRB-
cord-015021-pol2qm74	3521	19	ultrafiltrate	ultrafiltrate	JJ
cord-015021-pol2qm74	3521	20	samples	sample	NNS
cord-015021-pol2qm74	3521	21	.	.	.
cord-015021-pol2qm74	3522	1	The	the	DT
cord-015021-pol2qm74	3522	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3522	3	blood	blood	NN
cord-015021-pol2qm74	3522	4	level	level	NN
cord-015021-pol2qm74	3522	5	ranged	range	VBD
cord-015021-pol2qm74	3522	6	from	from	IN
cord-015021-pol2qm74	3522	7	17.4	17.4	CD
cord-015021-pol2qm74	3522	8	to	to	IN
cord-015021-pol2qm74	3522	9	3061.7	3061.7	CD
cord-015021-pol2qm74	3522	10	U	U	NNP
cord-015021-pol2qm74	3522	11	/	/	SYM
cord-015021-pol2qm74	3522	12	ml	ml	XX
cord-015021-pol2qm74	3523	1	(	(	-LRB-
cord-015021-pol2qm74	3523	2	mean	mean	VB
cord-015021-pol2qm74	3523	3	518.2	518.2	CD
cord-015021-pol2qm74	3523	4	,	,	,
cord-015021-pol2qm74	3523	5	SD	SD	NNP
cord-015021-pol2qm74	3523	6	686.8	686.8	CD
cord-015021-pol2qm74	3523	7	)	)	-RRB-
cord-015021-pol2qm74	3523	8	.	.	.
cord-015021-pol2qm74	3524	1	The	the	DT
cord-015021-pol2qm74	3524	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	3524	3	level	level	NN
cord-015021-pol2qm74	3524	4	in	in	IN
cord-015021-pol2qm74	3524	5	positive	positive	JJ
cord-015021-pol2qm74	3524	6	ultrafiltrate	ultrafiltrate	JJ
cord-015021-pol2qm74	3524	7	samples	sample	NNS
cord-015021-pol2qm74	3524	8	ranged	range	VBD
cord-015021-pol2qm74	3524	9	from	from	IN
cord-015021-pol2qm74	3524	10	21.0	21.0	CD
cord-015021-pol2qm74	3524	11	to	to	IN
cord-015021-pol2qm74	3524	12	1150.2	1150.2	CD
cord-015021-pol2qm74	3524	13	U	U	NNP
cord-015021-pol2qm74	3524	14	/	/	SYM
cord-015021-pol2qm74	3524	15	ml	ml	XX
cord-015021-pol2qm74	3525	1	(	(	-LRB-
cord-015021-pol2qm74	3525	2	mean	mean	VB
cord-015021-pol2qm74	3526	1	252.2	252.2	CD
cord-015021-pol2qm74	3526	2	,	,	,
cord-015021-pol2qm74	3526	3	SD	SD	NNP
cord-015021-pol2qm74	3526	4	401.8	401.8	CD
cord-015021-pol2qm74	3526	5	)	)	-RRB-
cord-015021-pol2qm74	3526	6	.	.	.
cord-015021-pol2qm74	3527	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3527	2	:	:	:
cord-015021-pol2qm74	3528	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3528	2	preliminary	preliminary	JJ
cord-015021-pol2qm74	3528	3	results	result	NNS
cord-015021-pol2qm74	3528	4	suggest	suggest	VBP
cord-015021-pol2qm74	3528	5	that	that	IN
cord-015021-pol2qm74	3528	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	3528	7	is	be	VBZ
cord-015021-pol2qm74	3528	8	present	present	JJ
cord-015021-pol2qm74	3528	9	in	in	IN
cord-015021-pol2qm74	3528	10	bloodstream	bloodstream	NN
cord-015021-pol2qm74	3528	11	of	of	IN
cord-015021-pol2qm74	3528	12	septic	septic	JJ
cord-015021-pol2qm74	3528	13	patients	patient	NNS
cord-015021-pol2qm74	3528	14	.	.	.
cord-015021-pol2qm74	3529	1	We	-PRON-	PRP
cord-015021-pol2qm74	3529	2	assume	assume	VBP
cord-015021-pol2qm74	3529	3	we	-PRON-	PRP
cord-015021-pol2qm74	3529	4	coUld	coUld	MD
cord-015021-pol2qm74	3529	5	not	not	RB
cord-015021-pol2qm74	3529	6	detect	detect	VB
cord-015021-pol2qm74	3529	7	TNFa	TNFa	NNS
cord-015021-pol2qm74	3529	8	in	in	IN
cord-015021-pol2qm74	3529	9	any	any	DT
cord-015021-pol2qm74	3529	10	sample	sample	NN
cord-015021-pol2qm74	3529	11	because	because	IN
cord-015021-pol2qm74	3529	12	we	-PRON-	PRP
cord-015021-pol2qm74	3529	13	usually	usually	RB
cord-015021-pol2qm74	3529	14	started	start	VBD
cord-015021-pol2qm74	3529	15	observations	observation	NNS
cord-015021-pol2qm74	3529	16	when	when	WRB
cord-015021-pol2qm74	3529	17	septic	septic	JJ
cord-015021-pol2qm74	3529	18	state	state	NN
cord-015021-pol2qm74	3529	19	had	have	VBD
cord-015021-pol2qm74	3529	20	developed	develop	VBN
cord-015021-pol2qm74	3529	21	.	.	.
cord-015021-pol2qm74	3530	1	CVVH	CVVH	NNP
cord-015021-pol2qm74	3530	2	could	could	MD
cord-015021-pol2qm74	3530	3	extract	extract	VB
cord-015021-pol2qm74	3530	4	cytokines	cytokine	NNS
cord-015021-pol2qm74	3530	5	from	from	IN
cord-015021-pol2qm74	3530	6	the	the	DT
cord-015021-pol2qm74	3530	7	circulating	circulate	VBG
cord-015021-pol2qm74	3530	8	blood	blood	NN
cord-015021-pol2qm74	3530	9	.	.	.
cord-015021-pol2qm74	3531	1	It	-PRON-	PRP
cord-015021-pol2qm74	3531	2	remains	remain	VBZ
cord-015021-pol2qm74	3531	3	under	under	IN
cord-015021-pol2qm74	3531	4	discussion	discussion	NN
cord-015021-pol2qm74	3531	5	,	,	,
cord-015021-pol2qm74	3531	6	whether	whether	IN
cord-015021-pol2qm74	3531	7	that	that	DT
cord-015021-pol2qm74	3531	8	extraction	extraction	NN
cord-015021-pol2qm74	3531	9	may	may	MD
cord-015021-pol2qm74	3531	10	be	be	VB
cord-015021-pol2qm74	3531	11	beneficial	beneficial	JJ
cord-015021-pol2qm74	3531	12	to	to	IN
cord-015021-pol2qm74	3531	13	patients	patient	NNS
cord-015021-pol2qm74	3531	14	with	with	IN
cord-015021-pol2qm74	3531	15	MOF	MOF	NNP
cord-015021-pol2qm74	3531	16	.	.	.
cord-015021-pol2qm74	3532	1	The	the	DT
cord-015021-pol2qm74	3532	2	pattern	pattern	NN
cord-015021-pol2qm74	3532	3	of	of	IN
cord-015021-pol2qm74	3532	4	some	some	DT
cord-015021-pol2qm74	3532	5	significant	significant	JJ
cord-015021-pol2qm74	3532	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	3532	7	TNF	TNF	NNP
cord-015021-pol2qm74	3532	8	,	,	,
cord-015021-pol2qm74	3532	9	IL-1	IL-1	NNP
cord-015021-pol2qm74	3532	10	and	and	CC
cord-015021-pol2qm74	3532	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	3532	12	and	and	CC
cord-015021-pol2qm74	3532	13	their	-PRON-	PRP$
cord-015021-pol2qm74	3532	14	pharmacomodulation	pharmacomodulation	NN
cord-015021-pol2qm74	3532	15	were	be	VBD
cord-015021-pol2qm74	3532	16	evaluated	evaluate	VBN
cord-015021-pol2qm74	3532	17	in	in	IN
cord-015021-pol2qm74	3532	18	an	an	DT
cord-015021-pol2qm74	3532	19	experimental	experimental	JJ
cord-015021-pol2qm74	3532	20	model	model	NN
cord-015021-pol2qm74	3532	21	of	of	IN
cord-015021-pol2qm74	3532	22	polimicrobial	polimicrobial	JJ
cord-015021-pol2qm74	3532	23	sepsis	sepsis	NN
cord-015021-pol2qm74	3532	24	induced	induce	VBN
cord-015021-pol2qm74	3532	25	in	in	IN
cord-015021-pol2qm74	3532	26	CD-1	CD-1	NNP
cord-015021-pol2qm74	3532	27	mice	mouse	NNS
cord-015021-pol2qm74	3532	28	by	by	IN
cord-015021-pol2qm74	3532	29	cecal	cecal	JJ
cord-015021-pol2qm74	3532	30	ligation	ligation	NN
cord-015021-pol2qm74	3532	31	and	and	CC
cord-015021-pol2qm74	3532	32	puncture	puncture	NN
cord-015021-pol2qm74	3532	33	(	(	-LRB-
cord-015021-pol2qm74	3532	34	CLP	CLP	NNP
cord-015021-pol2qm74	3532	35	)	)	-RRB-
cord-015021-pol2qm74	3532	36	in	in	IN
cord-015021-pol2qm74	3532	37	order	order	NN
cord-015021-pol2qm74	3532	38	to	to	TO
cord-015021-pol2qm74	3532	39	understand	understand	VB
cord-015021-pol2qm74	3532	40	their	-PRON-	PRP$
cord-015021-pol2qm74	3532	41	roles	role	NNS
cord-015021-pol2qm74	3532	42	.	.	.
cord-015021-pol2qm74	3533	1	This	this	DT
cord-015021-pol2qm74	3533	2	model	model	NN
cord-015021-pol2qm74	3533	3	of	of	IN
cord-015021-pol2qm74	3533	4	sepsis	sepsis	NN
cord-015021-pol2qm74	3533	5	,	,	,
cord-015021-pol2qm74	3533	6	which	which	WDT
cord-015021-pol2qm74	3533	7	resembles	resemble	VBZ
cord-015021-pol2qm74	3533	8	the	the	DT
cord-015021-pol2qm74	3533	9	clinical	clinical	JJ
cord-015021-pol2qm74	3533	10	situation	situation	NN
cord-015021-pol2qm74	3533	11	of	of	IN
cord-015021-pol2qm74	3533	12	bowel	bowel	NN
cord-015021-pol2qm74	3533	13	perforation	perforation	NN
cord-015021-pol2qm74	3533	14	,	,	,
cord-015021-pol2qm74	3533	15	was	be	VBD
cord-015021-pol2qm74	3533	16	also	also	RB
cord-015021-pol2qm74	3533	17	compared	compare	VBN
cord-015021-pol2qm74	3533	18	with	with	IN
cord-015021-pol2qm74	3533	19	that	that	DT
cord-015021-pol2qm74	3533	20	induced	induce	VBN
cord-015021-pol2qm74	3533	21	by	by	IN
cord-015021-pol2qm74	3533	22	administration	administration	NN
cord-015021-pol2qm74	3533	23	of	of	IN
cord-015021-pol2qm74	3533	24	pure	pure	JJ
cord-015021-pol2qm74	3533	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3533	26	(	(	-LRB-
cord-015021-pol2qm74	3533	27	LPS	LPS	NNP
cord-015021-pol2qm74	3533	28	)	)	-RRB-
cord-015021-pol2qm74	3533	29	.	.	.
cord-015021-pol2qm74	3534	1	TNF	TNF	NNP
cord-015021-pol2qm74	3534	2	was	be	VBD
cord-015021-pol2qm74	3534	3	detectable	detectable	JJ
cord-015021-pol2qm74	3534	4	in	in	IN
cord-015021-pol2qm74	3534	5	serum	serum	NN
cord-015021-pol2qm74	3534	6	and	and	CC
cord-015021-pol2qm74	3534	7	tissues	tissue	NNS
cord-015021-pol2qm74	3534	8	during	during	IN
cord-015021-pol2qm74	3534	9	the	the	DT
cord-015021-pol2qm74	3534	10	first	first	JJ
cord-015021-pol2qm74	3534	11	4h	4h	CD
cord-015021-pol2qm74	3534	12	with	with	IN
cord-015021-pol2qm74	3534	13	a	a	DT
cord-015021-pol2qm74	3534	14	peak	peak	NN
cord-015021-pol2qm74	3534	15	2h	2h	NN
cord-015021-pol2qm74	3534	16	after	after	IN
cord-015021-pol2qm74	3534	17	CLP	CLP	NNP
cord-015021-pol2qm74	3534	18	at	at	IN
cord-015021-pol2qm74	3534	19	a	a	DT
cord-015021-pol2qm74	3534	20	significantly	significantly	RB
cord-015021-pol2qm74	3534	21	lower	low	JJR
cord-015021-pol2qm74	3534	22	level	level	NN
cord-015021-pol2qm74	3534	23	than	than	IN
cord-015021-pol2qm74	3534	24	after	after	IN
cord-015021-pol2qm74	3534	25	LPS	lp	NNS
cord-015021-pol2qm74	3534	26	.	.	.
cord-015021-pol2qm74	3535	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	3535	2	was	be	VBD
cord-015021-pol2qm74	3535	3	measurable	measurable	JJ
cord-015021-pol2qm74	3535	4	in	in	IN
cord-015021-pol2qm74	3535	5	serum	serum	NN
cord-015021-pol2qm74	3535	6	only	only	RB
cord-015021-pol2qm74	3535	7	after	after	IN
cord-015021-pol2qm74	3535	8	24h	24h	NNS
cord-015021-pol2qm74	3535	9	,	,	,
cord-015021-pol2qm74	3535	10	significantly	significantly	RB
cord-015021-pol2qm74	3535	11	increased	increase	VBD
cord-015021-pol2qm74	3535	12	in	in	IN
cord-015021-pol2qm74	3535	13	spleen	spleen	NN
cord-015021-pol2qm74	3535	14	and	and	CC
cord-015021-pol2qm74	3535	15	liver	liver	NN
cord-015021-pol2qm74	3535	16	after	after	IN
cord-015021-pol2qm74	3535	17	4	4	CD
cord-015021-pol2qm74	3535	18	and	and	CC
cord-015021-pol2qm74	3535	19	8h	8h	NNP
cord-015021-pol2qm74	3535	20	and	and	CC
cord-015021-pol2qm74	3535	21	in	in	IN
cord-015021-pol2qm74	3535	22	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	3535	23	lymphonodes	lymphonode	NNS
cord-015021-pol2qm74	3535	24	from	from	IN
cord-015021-pol2qm74	3535	25	8	8	CD
cord-015021-pol2qm74	3535	26	to	to	IN
cord-015021-pol2qm74	3535	27	24h	24h	NNS
cord-015021-pol2qm74	3535	28	after	after	IN
cord-015021-pol2qm74	3535	29	CLP	CLP	NNP
cord-015021-pol2qm74	3535	30	compared	compare	VBN
cord-015021-pol2qm74	3535	31	with	with	IN
cord-015021-pol2qm74	3535	32	shammice	shammice	NN
cord-015021-pol2qm74	3535	33	.	.	.
cord-015021-pol2qm74	3536	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3536	2	was	be	VBD
cord-015021-pol2qm74	3536	3	significantly	significantly	RB
cord-015021-pol2qm74	3536	4	increased	increase	VBN
cord-015021-pol2qm74	3536	5	in	in	IN
cord-015021-pol2qm74	3536	6	serum	serum	NN
cord-015021-pol2qm74	3536	7	throughout	throughout	IN
cord-015021-pol2qm74	3536	8	the	the	DT
cord-015021-pol2qm74	3536	9	first	first	JJ
cord-015021-pol2qm74	3536	10	16h	16h	NNS
cord-015021-pol2qm74	3536	11	after	after	IN
cord-015021-pol2qm74	3536	12	CLP	CLP	NNP
cord-015021-pol2qm74	3536	13	.	.	.
cord-015021-pol2qm74	3537	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	3537	2	with	with	IN
cord-015021-pol2qm74	3537	3	dexamethasone	dexamethasone	NN
cord-015021-pol2qm74	3537	4	(	(	-LRB-
cord-015021-pol2qm74	3537	5	DEX	DEX	NNP
cord-015021-pol2qm74	3537	6	)	)	-RRB-
cord-015021-pol2qm74	3537	7	,	,	,
cord-015021-pol2qm74	3537	8	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	3537	9	(	(	-LRB-
cord-015021-pol2qm74	3537	10	IBU	IBU	NNP
cord-015021-pol2qm74	3537	11	)	)	-RRB-
cord-015021-pol2qm74	3537	12	and	and	CC
cord-015021-pol2qm74	3537	13	nitro	nitro	NN
cord-015021-pol2qm74	3537	14	-	-	HYPH
cord-015021-pol2qm74	3537	15	L	l	NN
cord-015021-pol2qm74	3537	16	-	-	HYPH
cord-015021-pol2qm74	3537	17	arginine	arginine	NN
cord-015021-pol2qm74	3537	18	(	(	-LRB-
cord-015021-pol2qm74	3537	19	N	N	NNP
cord-015021-pol2qm74	3537	20	-	-	HYPH
cord-015021-pol2qm74	3537	21	ARG	ARG	NNP
cord-015021-pol2qm74	3537	22	)	)	-RRB-
cord-015021-pol2qm74	3537	23	significantly	significantly	RB
cord-015021-pol2qm74	3537	24	reduced	reduce	VBD
cord-015021-pol2qm74	3537	25	the	the	DT
cord-015021-pol2qm74	3537	26	survival	survival	NN
cord-015021-pol2qm74	3537	27	time	time	NN
cord-015021-pol2qm74	3537	28	while	while	IN
cord-015021-pol2qm74	3537	29	chlorpromazine	chlorpromazine	NN
cord-015021-pol2qm74	3537	30	(	(	-LRB-
cord-015021-pol2qm74	3537	31	CPZ	CPZ	NNP
cord-015021-pol2qm74	3537	32	)	)	-RRB-
cord-015021-pol2qm74	3537	33	and	and	CC
cord-015021-pol2qm74	3537	34	TNF	TNF	NNP
cord-015021-pol2qm74	3537	35	did	do	VBD
cord-015021-pol2qm74	3537	36	not	not	RB
cord-015021-pol2qm74	3537	37	affect	affect	VB
cord-015021-pol2qm74	3537	38	it	-PRON-	PRP
cord-015021-pol2qm74	3537	39	.	.	.
cord-015021-pol2qm74	3538	1	Only	only	RB
cord-015021-pol2qm74	3538	2	the	the	DT
cord-015021-pol2qm74	3538	3	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	3538	4	and	and	CC
cord-015021-pol2qm74	3538	5	pentoxifylline	pentoxifylline	NNP
cord-015021-pol2qm74	3538	6	(	(	-LRB-
cord-015021-pol2qm74	3538	7	PTX	PTX	NNP
cord-015021-pol2qm74	3538	8	)	)	-RRB-
cord-015021-pol2qm74	3538	9	significantly	significantly	RB
cord-015021-pol2qm74	3538	10	increased	increase	VBD
cord-015021-pol2qm74	3538	11	the	the	DT
cord-015021-pol2qm74	3538	12	survival	survival	NN
cord-015021-pol2qm74	3538	13	in	in	IN
cord-015021-pol2qm74	3538	14	CLP	CLP	NNP
cord-015021-pol2qm74	3538	15	.	.	.
cord-015021-pol2qm74	3539	1	However	however	RB
cord-015021-pol2qm74	3539	2	CPZ	CPZ	NNP
cord-015021-pol2qm74	3539	3	and	and	CC
cord-015021-pol2qm74	3539	4	DEX	DEX	NNP
cord-015021-pol2qm74	3539	5	protected	protect	VBN
cord-015021-pol2qm74	3539	6	from	from	IN
cord-015021-pol2qm74	3539	7	LPS	LPS	NNP
cord-015021-pol2qm74	3539	8	-	-	HYPH
cord-015021-pol2qm74	3539	9	mor	mor	NNP
cord-015021-pol2qm74	3539	10	~	~	NFP
cord-015021-pol2qm74	3539	11	ality	ality	NN
cord-015021-pol2qm74	3539	12	.	.	.
cord-015021-pol2qm74	3540	1	In	in	IN
cord-015021-pol2qm74	3540	2	conclusion	conclusion	NN
cord-015021-pol2qm74	3540	3	,	,	,
cord-015021-pol2qm74	3540	4	by	by	IN
cord-015021-pol2qm74	3540	5	inhibiting	inhibit	VBG
cord-015021-pol2qm74	3540	6	TNF	TNF	NNP
cord-015021-pol2qm74	3540	7	with	with	IN
cord-015021-pol2qm74	3540	8	DEX	DEX	NNP
cord-015021-pol2qm74	3540	9	,	,	,
cord-015021-pol2qm74	3540	10	CPZ	CPZ	NNP
cord-015021-pol2qm74	3540	11	,	,	,
cord-015021-pol2qm74	3540	12	PTX	PTX	NNP
cord-015021-pol2qm74	3540	13	a	a	DT
cord-015021-pol2qm74	3540	14	reduced	reduce	VBN
cord-015021-pol2qm74	3540	15	,	,	,
cord-015021-pol2qm74	3540	16	unchanged	unchanged	JJ
cord-015021-pol2qm74	3540	17	and	and	CC
cord-015021-pol2qm74	3540	18	increased	increased	JJ
cord-015021-pol2qm74	3540	19	survival	survival	NN
cord-015021-pol2qm74	3540	20	time	time	NN
cord-015021-pol2qm74	3540	21	was	be	VBD
cord-015021-pol2qm74	3540	22	observed	observe	VBN
cord-015021-pol2qm74	3540	23	and	and	CC
cord-015021-pol2qm74	3540	24	by	by	IN
cord-015021-pol2qm74	3540	25	increasing	increase	VBG
cord-015021-pol2qm74	3540	26	TNF	TNF	NNP
cord-015021-pol2qm74	3540	27	with	with	IN
cord-015021-pol2qm74	3540	28	IBU	IBU	NNP
cord-015021-pol2qm74	3540	29	and	and	CC
cord-015021-pol2qm74	3540	30	TNF	TNF	NNP
cord-015021-pol2qm74	3540	31	administration	administration	NN
cord-015021-pol2qm74	3540	32	the	the	DT
cord-015021-pol2qm74	3540	33	survival	survival	NN
cord-015021-pol2qm74	3540	34	was	be	VBD
cord-015021-pol2qm74	3540	35	decreased	decrease	VBN
cord-015021-pol2qm74	3540	36	or	or	CC
cord-015021-pol2qm74	3540	37	unchanged	unchanged	JJ
cord-015021-pol2qm74	3540	38	respectively	respectively	RB
cord-015021-pol2qm74	3540	39	suggesting	suggest	VBG
cord-015021-pol2qm74	3540	40	that	that	IN
cord-015021-pol2qm74	3540	41	the	the	DT
cord-015021-pol2qm74	3540	42	modulation	modulation	NN
cord-015021-pol2qm74	3540	43	of	of	IN
cord-015021-pol2qm74	3540	44	this	this	DT
cord-015021-pol2qm74	3540	45	cytokine	cytokine	NN
cord-015021-pol2qm74	3540	46	does	do	VBZ
cord-015021-pol2qm74	3540	47	not	not	RB
cord-015021-pol2qm74	3540	48	seem	seem	VB
cord-015021-pol2qm74	3540	49	to	to	TO
cord-015021-pol2qm74	3540	50	play	play	VB
cord-015021-pol2qm74	3540	51	a	a	DT
cord-015021-pol2qm74	3540	52	significant	significant	JJ
cord-015021-pol2qm74	3540	53	role	role	NN
cord-015021-pol2qm74	3540	54	in	in	IN
cord-015021-pol2qm74	3540	55	CLP	CLP	NNP
cord-015021-pol2qm74	3540	56	unlike	unlike	IN
cord-015021-pol2qm74	3540	57	LPS	lp	NNS
cord-015021-pol2qm74	3541	1	_	_	NNP
cord-015021-pol2qm74	3541	2	Moreover	moreover	RB
cord-015021-pol2qm74	3541	3	the	the	DT
cord-015021-pol2qm74	3541	4	negative	negative	JJ
cord-015021-pol2qm74	3541	5	effects	effect	NNS
cord-015021-pol2qm74	3541	6	of	of	IN
cord-015021-pol2qm74	3541	7	IBU	IBU	NNP
cord-015021-pol2qm74	3541	8	and	and	CC
cord-015021-pol2qm74	3541	9	N	N	NNP
cord-015021-pol2qm74	3541	10	-	-	HYPH
cord-015021-pol2qm74	3541	11	ARG	ARG	NNP
cord-015021-pol2qm74	3541	12	suggest	suggest	VBP
cord-015021-pol2qm74	3541	13	an	an	DT
cord-015021-pol2qm74	3541	14	important	important	JJ
cord-015021-pol2qm74	3541	15	and	and	CC
cord-015021-pol2qm74	3541	16	protective	protective	JJ
cord-015021-pol2qm74	3541	17	role	role	NN
cord-015021-pol2qm74	3541	18	by	by	IN
cord-015021-pol2qm74	3541	19	prostaglandins	prostaglandin	NNS
cord-015021-pol2qm74	3541	20	and	and	CC
cord-015021-pol2qm74	3541	21	NO	no	RB
cord-015021-pol2qm74	3541	22	in	in	IN
cord-015021-pol2qm74	3541	23	CLP	CLP	NNP
cord-015021-pol2qm74	3541	24	.	.	.
cord-015021-pol2qm74	3542	1	To	to	TO
cord-015021-pol2qm74	3542	2	gain	gain	VB
cord-015021-pol2qm74	3542	3	more	more	JJR
cord-015021-pol2qm74	3542	4	insigths	insigth	NNS
cord-015021-pol2qm74	3542	5	on	on	IN
cord-015021-pol2qm74	3542	6	the	the	DT
cord-015021-pol2qm74	3542	7	contribution	contribution	NN
cord-015021-pol2qm74	3542	8	of	of	IN
cord-015021-pol2qm74	3542	9	TNF~	TNF~	NNP
cord-015021-pol2qm74	3542	10	,	,	,
cord-015021-pol2qm74	3542	11	IL	IL	NNP
cord-015021-pol2qm74	3542	12	-	-	HYPH
cord-015021-pol2qm74	3542	13	I~	I~	NNP
cord-015021-pol2qm74	3542	14	and	and	CC
cord-015021-pol2qm74	3542	15	IF	if	IN
cord-015021-pol2qm74	3542	16	7	7	CD
cord-015021-pol2qm74	3542	17	to	to	IN
cord-015021-pol2qm74	3542	18	LPS	LPS	NNP
cord-015021-pol2qm74	3542	19	toxicity	toxicity	NN
cord-015021-pol2qm74	3542	20	,	,	,
cord-015021-pol2qm74	3542	21	we	-PRON-	PRP
cord-015021-pol2qm74	3542	22	explored	explore	VBD
cord-015021-pol2qm74	3542	23	the	the	DT
cord-015021-pol2qm74	3542	24	time	time	NN
cord-015021-pol2qm74	3542	25	-	-	HYPH
cord-015021-pol2qm74	3542	26	course	course	NN
cord-015021-pol2qm74	3542	27	of	of	IN
cord-015021-pol2qm74	3542	28	the	the	DT
cord-015021-pol2qm74	3542	29	cytokine	cytokine	NN
cord-015021-pol2qm74	3542	30	production	production	NN
cord-015021-pol2qm74	3542	31	in	in	IN
cord-015021-pol2qm74	3542	32	Ealb	Ealb	NNP
cord-015021-pol2qm74	3542	33	/	/	SYM
cord-015021-pol2qm74	3542	34	C	c	NN
cord-015021-pol2qm74	3542	35	mice	mouse	NNS
cord-015021-pol2qm74	3542	36	given	give	VBN
cord-015021-pol2qm74	3542	37	different	different	JJ
cord-015021-pol2qm74	3542	38	doses	dose	NNS
cord-015021-pol2qm74	3542	39	,	,	,
cord-015021-pol2qm74	3542	40	from	from	IN
cord-015021-pol2qm74	3542	41	the	the	DT
cord-015021-pol2qm74	3542	42	lethal	lethal	JJ
cord-015021-pol2qm74	3542	43	(=	(=	NNP
cord-015021-pol2qm74	3542	44	3	3	CD
cord-015021-pol2qm74	3542	45	LD50	LD50	NNP
cord-015021-pol2qm74	3542	46	)	)	-RRB-
cord-015021-pol2qm74	3542	47	to	to	IN
cord-015021-pol2qm74	3542	48	the	the	DT
cord-015021-pol2qm74	3542	49	sublethal	sublethal	NN
cord-015021-pol2qm74	3542	50	(=	(=	NNP
cord-015021-pol2qm74	3542	51	1/3	1/3	CD
cord-015021-pol2qm74	3542	52	LD50	LD50	NNP
cord-015021-pol2qm74	3542	53	)	)	-RRB-
cord-015021-pol2qm74	3542	54	of	of	IN
cord-015021-pol2qm74	3542	55	three	three	CD
cord-015021-pol2qm74	3542	56	different	different	JJ
cord-015021-pol2qm74	3542	57	LPS	lp	NNS
cord-015021-pol2qm74	3543	1	(	(	-LRB-
cord-015021-pol2qm74	3543	2	E.coli	E.coli	NNS
cord-015021-pol2qm74	3543	3	OIII	OIII	NNP
cord-015021-pol2qm74	3543	4	:	:	:
cord-015021-pol2qm74	3543	5	B4	B4	NNP
cord-015021-pol2qm74	3543	6	and	and	CC
cord-015021-pol2qm74	3543	7	026	026	CD
cord-015021-pol2qm74	3543	8	:	:	:
cord-015021-pol2qm74	3543	9	B6	b6	NN
cord-015021-pol2qm74	3543	10	;	;	:
cord-015021-pol2qm74	3543	11	P.aeruginosa	P.aeruginosa	NNP
cord-015021-pol2qm74	3543	12	R261	R261	NNPS
cord-015021-pol2qm74	3543	13	)	)	-RRB-
cord-015021-pol2qm74	3543	14	endowed	endow	VBN
cord-015021-pol2qm74	3543	15	with	with	IN
cord-015021-pol2qm74	3543	16	different	different	JJ
cord-015021-pol2qm74	3543	17	degree	degree	NN
cord-015021-pol2qm74	3543	18	of	of	IN
cord-015021-pol2qm74	3543	19	toxicity	toxicity	NN
cord-015021-pol2qm74	3543	20	Cytokines	Cytokines	NNPS
cord-015021-pol2qm74	3543	21	were	be	VBD
cord-015021-pol2qm74	3543	22	measured	measure	VBN
cord-015021-pol2qm74	3543	23	in	in	IN
cord-015021-pol2qm74	3543	24	serum	serum	NN
cord-015021-pol2qm74	3543	25	and	and	CC
cord-015021-pol2qm74	3543	26	organs	organ	NNS
cord-015021-pol2qm74	3543	27	with	with	IN
cord-015021-pol2qm74	3543	28	specific	specific	JJ
cord-015021-pol2qm74	3543	29	ELISAs	elisa	NNS
cord-015021-pol2qm74	3543	30	up	up	RP
cord-015021-pol2qm74	3543	31	to	to	IN
cord-015021-pol2qm74	3543	32	I0	I0	NNP
cord-015021-pol2qm74	3543	33	h	h	NN
cord-015021-pol2qm74	3543	34	after	after	IN
cord-015021-pol2qm74	3543	35	LPS	LPS	NNP
cord-015021-pol2qm74	3543	36	administration	administration	NN
cord-015021-pol2qm74	3543	37	.	.	.
cord-015021-pol2qm74	3544	1	Results	result	NNS
cord-015021-pol2qm74	3544	2	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	3544	3	that	that	IN
cord-015021-pol2qm74	3544	4	i	i	PRP
cord-015021-pol2qm74	3544	5	)	)	-RRB-
cord-015021-pol2qm74	3544	6	circulating	circulate	VBG
cord-015021-pol2qm74	3544	7	and	and	CC
cord-015021-pol2qm74	3544	8	organ	organ	NN
cord-015021-pol2qm74	3544	9	levels	level	NNS
cord-015021-pol2qm74	3544	10	of	of	IN
cord-015021-pol2qm74	3544	11	TNF~	TNF~	NNS
cord-015021-pol2qm74	3544	12	do	do	VBP
cord-015021-pol2qm74	3544	13	not	not	RB
cord-015021-pol2qm74	3544	14	reflect	reflect	VB
cord-015021-pol2qm74	3544	15	LPS	LPS	NNP
cord-015021-pol2qm74	3544	16	toxicity	toxicity	NN
cord-015021-pol2qm74	3544	17	.	.	.
cord-015021-pol2qm74	3545	1	In	in	IN
cord-015021-pol2qm74	3545	2	fact	fact	NN
cord-015021-pol2qm74	3545	3	,	,	,
cord-015021-pol2qm74	3545	4	the	the	DT
cord-015021-pol2qm74	3545	5	lethal	lethal	JJ
cord-015021-pol2qm74	3545	6	dose	dose	NN
cord-015021-pol2qm74	3545	7	of	of	IN
cord-015021-pol2qm74	3545	8	LPS	LPS	NNP
cord-015021-pol2qm74	3545	9	026	026	NN
cord-015021-pol2qm74	3545	10	:	:	:
cord-015021-pol2qm74	3545	11	B6	b6	NN
cord-015021-pol2qm74	3545	12	induced	induce	VBN
cord-015021-pol2qm74	3545	13	as	as	RB
cord-015021-pol2qm74	3545	14	much	much	RB
cord-015021-pol2qm74	3545	15	TNF~	tnf~	CD
cord-015021-pol2qm74	3545	16	as	as	IN
cord-015021-pol2qm74	3545	17	the	the	DT
cord-015021-pol2qm74	3545	18	sublethal	sublethal	NN
cord-015021-pol2qm74	3545	19	dose	dose	NN
cord-015021-pol2qm74	3545	20	of	of	IN
cord-015021-pol2qm74	3545	21	LPS	LPS	NNP
cord-015021-pol2qm74	3545	22	0111	0111	CD
cord-015021-pol2qm74	3545	23	:	:	:
cord-015021-pol2qm74	3545	24	B4	B4	NNP
cord-015021-pol2qm74	3545	25	;	;	:
cord-015021-pol2qm74	3545	26	furthermore	furthermore	RB
cord-015021-pol2qm74	3545	27	,	,	,
cord-015021-pol2qm74	3545	28	LPS	LPS	NNP
cord-015021-pol2qm74	3545	29	R261	R261	NNPS
cord-015021-pol2qm74	3545	30	,	,	,
cord-015021-pol2qm74	3545	31	whose	whose	WP$
cord-015021-pol2qm74	3545	32	cytokine	cytokine	NN
cord-015021-pol2qm74	3545	33	inducing	induce	VBG
cord-015021-pol2qm74	3545	34	capability	capability	NN
cord-015021-pol2qm74	3545	35	is	be	VBZ
cord-015021-pol2qm74	3545	36	far	far	RB
cord-015021-pol2qm74	3545	37	lower	low	JJR
cord-015021-pol2qm74	3545	38	than	than	IN
cord-015021-pol2qm74	3545	39	that	that	DT
cord-015021-pol2qm74	3545	40	of	of	IN
cord-015021-pol2qm74	3545	41	LPS	LPS	NNP
cord-015021-pol2qm74	3545	42	from	from	IN
cord-015021-pol2qm74	3545	43	E.coli	E.coli	NNS
cord-015021-pol2qm74	3545	44	,	,	,
cord-015021-pol2qm74	3545	45	induced	induce	VBN
cord-015021-pol2qm74	3545	46	higher	high	JJR
cord-015021-pol2qm74	3545	47	TNF~	tnf~	CD
cord-015021-pol2qm74	3545	48	levels	level	NNS
cord-015021-pol2qm74	3545	49	at	at	IN
cord-015021-pol2qm74	3545	50	the	the	DT
cord-015021-pol2qm74	3545	51	sublethal	sublethal	NN
cord-015021-pol2qm74	3545	52	than	than	IN
cord-015021-pol2qm74	3545	53	at	at	IN
cord-015021-pol2qm74	3545	54	the	the	DT
cord-015021-pol2qm74	3545	55	lethal	lethal	JJ
cord-015021-pol2qm74	3545	56	dose	dose	NN
cord-015021-pol2qm74	3545	57	.	.	.
cord-015021-pol2qm74	3546	1	In	in	IN
cord-015021-pol2qm74	3546	2	addition	addition	NN
cord-015021-pol2qm74	3546	3	,	,	,
cord-015021-pol2qm74	3546	4	policlonal	policlonal	NNP
cord-015021-pol2qm74	3546	5	anti	anti	NNP
cord-015021-pol2qm74	3546	6	TNF	TNF	NNP
cord-015021-pol2qm74	3546	7	Ab	Ab	NNP
cord-015021-pol2qm74	3546	8	,	,	,
cord-015021-pol2qm74	3546	9	that	that	WDT
cord-015021-pol2qm74	3546	10	were	be	VBD
cord-015021-pol2qm74	3546	11	able	able	JJ
cord-015021-pol2qm74	3546	12	to	to	TO
cord-015021-pol2qm74	3546	13	protect	protect	VB
cord-015021-pol2qm74	3546	14	mice	mouse	NNS
cord-015021-pol2qm74	3546	15	from	from	IN
cord-015021-pol2qm74	3546	16	E.coli	e.coli	JJ
cord-015021-pol2qm74	3546	17	LPS	LPS	NNP
cord-015021-pol2qm74	3546	18	induced	induce	VBN
cord-015021-pol2qm74	3546	19	mortality	mortality	NN
cord-015021-pol2qm74	3546	20	,	,	,
cord-015021-pol2qm74	3546	21	failed	fail	VBD
cord-015021-pol2qm74	3546	22	in	in	IN
cord-015021-pol2qm74	3546	23	mice	mouse	NNS
cord-015021-pol2qm74	3546	24	treated	treat	VBN
cord-015021-pol2qm74	3546	25	with	with	IN
cord-015021-pol2qm74	3546	26	LPS	LPS	NNP
cord-015021-pol2qm74	3546	27	R261	R261	NNS
cord-015021-pol2qm74	3546	28	2	2	CD
cord-015021-pol2qm74	3546	29	)	)	-RRB-
cord-015021-pol2qm74	3547	1	Circulating	circulate	VBG
cord-015021-pol2qm74	3547	2	IL	IL	NNP
cord-015021-pol2qm74	3547	3	-	-	HYPH
cord-015021-pol2qm74	3547	4	I~	I~	NNP
cord-015021-pol2qm74	3547	5	levels	level	NNS
cord-015021-pol2qm74	3547	6	are	be	VBP
cord-015021-pol2qm74	3547	7	generally	generally	RB
cord-015021-pol2qm74	3547	8	low	low	JJ
cord-015021-pol2qm74	3547	9	and	and	CC
cord-015021-pol2qm74	3547	10	increase	increase	VBP
cord-015021-pol2qm74	3547	11	significantly	significantly	RB
cord-015021-pol2qm74	3547	12	only	only	RB
cord-015021-pol2qm74	3547	13	in	in	IN
cord-015021-pol2qm74	3547	14	muribond	muribond	NN
cord-015021-pol2qm74	3547	15	animals	animal	NNS
cord-015021-pol2qm74	3547	16	.	.	.
cord-015021-pol2qm74	3548	1	On	on	IN
cord-015021-pol2qm74	3548	2	the	the	DT
cord-015021-pol2qm74	3548	3	contrary	contrary	NN
cord-015021-pol2qm74	3548	4	,	,	,
cord-015021-pol2qm74	3548	5	in	in	IN
cord-015021-pol2qm74	3548	6	spleen	spleen	NN
cord-015021-pol2qm74	3548	7	and	and	CC
cord-015021-pol2qm74	3548	8	lung	lung	NN
cord-015021-pol2qm74	3548	9	very	very	RB
cord-015021-pol2qm74	3548	10	high	high	JJ
cord-015021-pol2qm74	3548	11	levels	level	NNS
cord-015021-pol2qm74	3548	12	of	of	IN
cord-015021-pol2qm74	3548	13	IL	IL	NNP
cord-015021-pol2qm74	3548	14	-	-	HYPH
cord-015021-pol2qm74	3548	15	I~	I~	NNP
cord-015021-pol2qm74	3548	16	are	be	VBP
cord-015021-pol2qm74	3548	17	persistent	persistent	JJ
cord-015021-pol2qm74	3548	18	from	from	IN
cord-015021-pol2qm74	3548	19	I	-PRON-	PRP
cord-015021-pol2qm74	3548	20	to	to	IN
cord-015021-pol2qm74	3548	21	8	8	CD
cord-015021-pol2qm74	3548	22	h	h	NN
cord-015021-pol2qm74	3548	23	post	post	NN
cord-015021-pol2qm74	3548	24	LPS	LPS	NNP
cord-015021-pol2qm74	3548	25	administration	administration	NN
cord-015021-pol2qm74	3549	1	Moreover	moreover	RB
cord-015021-pol2qm74	3549	2	,	,	,
cord-015021-pol2qm74	3549	3	the	the	DT
cord-015021-pol2qm74	3549	4	treatment	treatment	NN
cord-015021-pol2qm74	3549	5	with	with	IN
cord-015021-pol2qm74	3549	6	6	6	CD
cord-015021-pol2qm74	3549	7	mgr	mgr	NN
cord-015021-pol2qm74	3549	8	of	of	IN
cord-015021-pol2qm74	3549	9	neutralizing	neutralize	VBG
cord-015021-pol2qm74	3549	10	policlonal	policlonal	NNP
cord-015021-pol2qm74	3549	11	anti	anti	FW
cord-015021-pol2qm74	3549	12	IL	IL	NNP
cord-015021-pol2qm74	3549	13	-	-	HYPH
cord-015021-pol2qm74	3549	14	I~	I~	NNP
cord-015021-pol2qm74	3549	15	Ab	Ab	NNP
cord-015021-pol2qm74	3549	16	,	,	,
cord-015021-pol2qm74	3549	17	did	do	VBD
cord-015021-pol2qm74	3549	18	not	not	RB
cord-015021-pol2qm74	3549	19	modify	modify	VB
cord-015021-pol2qm74	3549	20	survival	survival	NN
cord-015021-pol2qm74	3549	21	in	in	IN
cord-015021-pol2qm74	3549	22	LPS	lp	NNS
cord-015021-pol2qm74	3549	23	challenged	challenge	VBD
cord-015021-pol2qm74	3549	24	mice	mouse	NNS
cord-015021-pol2qm74	3549	25	.	.	.
cord-015021-pol2qm74	3550	1	3	3	LS
cord-015021-pol2qm74	3550	2	)	)	-RRB-
cord-015021-pol2qm74	3551	1	Circulating	circulate	VBG
cord-015021-pol2qm74	3551	2	and	and	CC
cord-015021-pol2qm74	3551	3	organ	organ	NN
cord-015021-pol2qm74	3551	4	levels	level	NNS
cord-015021-pol2qm74	3551	5	of	of	IN
cord-015021-pol2qm74	3551	6	IF	if	NN
cord-015021-pol2qm74	3551	7	7	7	CD
cord-015021-pol2qm74	3551	8	are	be	VBP
cord-015021-pol2qm74	3551	9	proportional	proportional	JJ
cord-015021-pol2qm74	3551	10	to	to	IN
cord-015021-pol2qm74	3551	11	the	the	DT
cord-015021-pol2qm74	3551	12	dose	dose	NN
cord-015021-pol2qm74	3551	13	and	and	CC
cord-015021-pol2qm74	3551	14	degree	degree	NN
cord-015021-pol2qm74	3551	15	of	of	IN
cord-015021-pol2qm74	3551	16	toxicity	toxicity	NN
cord-015021-pol2qm74	3551	17	of	of	IN
cord-015021-pol2qm74	3551	18	all	all	PDT
cord-015021-pol2qm74	3551	19	the	the	DT
cord-015021-pol2qm74	3551	20	administered	administer	VBN
cord-015021-pol2qm74	3551	21	LPS	LPS	NNP
cord-015021-pol2qm74	3551	22	even	even	RB
cord-015021-pol2qm74	3551	23	if	if	IN
cord-015021-pol2qm74	3551	24	LPS	LPS	NNP
cord-015021-pol2qm74	3551	25	R261	R261	NNPS
cord-015021-pol2qm74	3551	26	was	be	VBD
cord-015021-pol2qm74	3551	27	again	again	RB
cord-015021-pol2qm74	3551	28	a	a	DT
cord-015021-pol2qm74	3551	29	less	less	RBR
cord-015021-pol2qm74	3551	30	efficient	efficient	JJ
cord-015021-pol2qm74	3551	31	cytokine	cytokine	NN
cord-015021-pol2qm74	3551	32	inducer	inducer	NN
cord-015021-pol2qm74	3551	33	than	than	IN
cord-015021-pol2qm74	3551	34	LPS	LPS	NNP
cord-015021-pol2qm74	3551	35	from	from	IN
cord-015021-pol2qm74	3551	36	E.coli	E.coli	NNS
cord-015021-pol2qm74	3551	37	.	.	.
cord-015021-pol2qm74	3552	1	CsA	CsA	NNP
cord-015021-pol2qm74	3552	2	is	be	VBZ
cord-015021-pol2qm74	3552	3	an	an	DT
cord-015021-pol2qm74	3552	4	immunos	immunos	JJ
cord-015021-pol2qm74	3552	5	~	~	CD
cord-015021-pol2qm74	3552	6	ppressive	ppressive	NNP
cord-015021-pol2qm74	3552	7	drug	drug	NN
cord-015021-pol2qm74	3552	8	,	,	,
cord-015021-pol2qm74	3552	9	able	able	JJ
cord-015021-pol2qm74	3552	10	to	to	TO
cord-015021-pol2qm74	3552	11	inhibit	inhibit	VB
cord-015021-pol2qm74	3552	12	gene	gene	NN
cord-015021-pol2qm74	3552	13	expression	expression	NN
cord-015021-pol2qm74	3552	14	for	for	IN
cord-015021-pol2qm74	3552	15	many	many	JJ
cord-015021-pol2qm74	3552	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	3552	17	,	,	,
cord-015021-pol2qm74	3552	18	including	include	VBG
cord-015021-pol2qm74	3552	19	IF	if	IN
cord-015021-pol2qm74	3552	20	7	7	CD
cord-015021-pol2qm74	3552	21	.	.	.
cord-015021-pol2qm74	3553	1	To	to	TO
cord-015021-pol2qm74	3553	2	study	study	VB
cord-015021-pol2qm74	3553	3	the	the	DT
cord-015021-pol2qm74	3553	4	effect	effect	NN
cord-015021-pol2qm74	3553	5	of	of	IN
cord-015021-pol2qm74	3553	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	3553	7	modulation	modulation	NN
cord-015021-pol2qm74	3553	8	on	on	IN
cord-015021-pol2qm74	3553	9	LPS	LPS	NNP
cord-015021-pol2qm74	3553	10	toxicity	toxicity	NN
cord-015021-pol2qm74	3553	11	,	,	,
cord-015021-pol2qm74	3553	12	CsA	CsA	NNP
cord-015021-pol2qm74	3553	13	was	be	VBD
cord-015021-pol2qm74	3553	14	administered	administer	VBN
cord-015021-pol2qm74	3553	15	to	to	IN
cord-015021-pol2qm74	3553	16	mice	mouse	NNS
cord-015021-pol2qm74	3553	17	twice	twice	RB
cord-015021-pol2qm74	3553	18	at	at	IN
cord-015021-pol2qm74	3553	19	the	the	DT
cord-015021-pol2qm74	3553	20	oral	oral	JJ
cord-015021-pol2qm74	3553	21	dose	dose	NN
cord-015021-pol2qm74	3553	22	of	of	IN
cord-015021-pol2qm74	3553	23	i00	i00	NNP
cord-015021-pol2qm74	3553	24	mg	mg	NNP
cord-015021-pol2qm74	3553	25	/	/	SYM
cord-015021-pol2qm74	3553	26	kg	kg	NNS
cord-015021-pol2qm74	3553	27	before	before	IN
cord-015021-pol2qm74	3553	28	the	the	DT
cord-015021-pol2qm74	3553	29	challenge	challenge	NN
cord-015021-pol2qm74	3553	30	with	with	IN
cord-015021-pol2qm74	3553	31	LPS	LPS	NNP
cord-015021-pol2qm74	3553	32	.	.	.
cord-015021-pol2qm74	3554	1	Mice	mouse	NNS
cord-015021-pol2qm74	3554	2	were	be	VBD
cord-015021-pol2qm74	3554	3	monitored	monitor	VBN
cord-015021-pol2qm74	3554	4	in	in	IN
cord-015021-pol2qm74	3554	5	terms	term	NNS
cord-015021-pol2qm74	3554	6	of	of	IN
cord-015021-pol2qm74	3554	7	mortality	mortality	NN
cord-015021-pol2qm74	3554	8	and	and	CC
cord-015021-pol2qm74	3554	9	TNF~	TNF~	NNP
cord-015021-pol2qm74	3554	10	,	,	,
cord-015021-pol2qm74	3554	11	IL	IL	NNP
cord-015021-pol2qm74	3554	12	-	-	HYPH
cord-015021-pol2qm74	3554	13	I~	I~	NNP
cord-015021-pol2qm74	3554	14	and	and	CC
cord-015021-pol2qm74	3554	15	IF	if	IN
cord-015021-pol2qm74	3554	16	7	7	CD
cord-015021-pol2qm74	3554	17	production	production	NN
cord-015021-pol2qm74	3554	18	.	.	.
cord-015021-pol2qm74	3555	1	Together	together	RB
cord-015021-pol2qm74	3555	2	with	with	IN
cord-015021-pol2qm74	3555	3	the	the	DT
cord-015021-pol2qm74	3555	4	total	total	JJ
cord-015021-pol2qm74	3555	5	ablation	ablation	NN
cord-015021-pol2qm74	3555	6	of	of	IN
cord-015021-pol2qm74	3555	7	IF7	if7	NN
cord-015021-pol2qm74	3555	8	,	,	,
cord-015021-pol2qm74	3555	9	the	the	DT
cord-015021-pol2qm74	3555	10	strong	strong	JJ
cord-015021-pol2qm74	3555	11	reduction	reduction	NN
cord-015021-pol2qm74	3555	12	of	of	IN
cord-015021-pol2qm74	3555	13	TNFu	TNFu	NNS
cord-015021-pol2qm74	3555	14	and	and	CC
cord-015021-pol2qm74	3555	15	unmodified	unmodified	JJ
cord-015021-pol2qm74	3555	16	IL	IL	NNP
cord-015021-pol2qm74	3555	17	-	-	HYPH
cord-015021-pol2qm74	3555	18	I~	I~	NNP
cord-015021-pol2qm74	3555	19	levels	level	NNS
cord-015021-pol2qm74	3555	20	,	,	,
cord-015021-pol2qm74	3555	21	a	a	DT
cord-015021-pol2qm74	3555	22	significant	significant	JJ
cord-015021-pol2qm74	3555	23	increase	increase	NN
cord-015021-pol2qm74	3555	24	of	of	IN
cord-015021-pol2qm74	3555	25	LPS	LPS	NNP
cord-015021-pol2qm74	3555	26	toxicity	toxicity	NN
cord-015021-pol2qm74	3555	27	was	be	VBD
cord-015021-pol2qm74	3555	28	also	also	RB
cord-015021-pol2qm74	3555	29	observed	observe	VBN
cord-015021-pol2qm74	3555	30	.	.	.
cord-015021-pol2qm74	3556	1	These	these	DT
cord-015021-pol2qm74	3556	2	results	result	NNS
cord-015021-pol2qm74	3556	3	suggest	suggest	VBP
cord-015021-pol2qm74	3556	4	the	the	DT
cord-015021-pol2qm74	3556	5	hypothesis	hypothesis	NN
cord-015021-pol2qm74	3556	6	that	that	IN
cord-015021-pol2qm74	3556	7	the	the	DT
cord-015021-pol2qm74	3556	8	numerous	numerous	JJ
cord-015021-pol2qm74	3556	9	factors	factor	NNS
cord-015021-pol2qm74	3556	10	that	that	WDT
cord-015021-pol2qm74	3556	11	jointly	jointly	RB
cord-015021-pol2qm74	3556	12	mediate	mediate	VB
cord-015021-pol2qm74	3556	13	LPS	LPS	NNP
cord-015021-pol2qm74	3556	14	toxic	toxic	JJ
cord-015021-pol2qm74	3556	15	effects	effect	NNS
cord-015021-pol2qm74	3556	16	,	,	,
cord-015021-pol2qm74	3556	17	can	can	MD
cord-015021-pol2qm74	3556	18	also	also	RB
cord-015021-pol2qm74	3556	19	be	be	VB
cord-015021-pol2qm74	3556	20	protective	protective	JJ
cord-015021-pol2qm74	3556	21	,	,	,
cord-015021-pol2qm74	3556	22	the	the	DT
cord-015021-pol2qm74	3556	23	final	final	JJ
cord-015021-pol2qm74	3556	24	outcome	outcome	NN
cord-015021-pol2qm74	3556	25	depending	depend	VBG
cord-015021-pol2qm74	3556	26	on	on	IN
cord-015021-pol2qm74	3556	27	their	-PRON-	PRP$
cord-015021-pol2qm74	3556	28	relative	relative	JJ
cord-015021-pol2qm74	3556	29	ratio	ratio	NN
cord-015021-pol2qm74	3556	30	rather	rather	RB
cord-015021-pol2qm74	3556	31	than	than	IN
cord-015021-pol2qm74	3556	32	on	on	IN
cord-015021-pol2qm74	3556	33	the	the	DT
cord-015021-pol2qm74	3556	34	absolute	absolute	JJ
cord-015021-pol2qm74	3556	35	amount	amount	NN
cord-015021-pol2qm74	3557	1	Interleukin-1	Interleukin-1	NNP
cord-015021-pol2qm74	3557	2	(	(	-LRB-
cord-015021-pol2qm74	3557	3	IL-1	IL-1	NNP
cord-015021-pol2qm74	3557	4	)	)	-RRB-
cord-015021-pol2qm74	3557	5	mediates	mediate	VBZ
cord-015021-pol2qm74	3557	6	the	the	DT
cord-015021-pol2qm74	3557	7	septic	septic	JJ
cord-015021-pol2qm74	3557	8	shock	shock	NN
cord-015021-pol2qm74	3557	9	syndrome	syndrome	NN
cord-015021-pol2qm74	3557	10	and	and	CC
cord-015021-pol2qm74	3557	11	affects	affect	VBZ
cord-015021-pol2qm74	3557	12	intestinal	intestinal	JJ
cord-015021-pol2qm74	3557	13	secretion	secretion	NN
cord-015021-pol2qm74	3557	14	in	in	IN
cord-015021-pol2qm74	3557	15	vitro	vitro	FW
cord-015021-pol2qm74	3557	16	.	.	.
cord-015021-pol2qm74	3558	1	We	-PRON-	PRP
cord-015021-pol2qm74	3558	2	studied	study	VBD
cord-015021-pol2qm74	3558	3	the	the	DT
cord-015021-pol2qm74	3558	4	intestinal	intestinal	JJ
cord-015021-pol2qm74	3558	5	production	production	NN
cord-015021-pol2qm74	3558	6	of	of	IN
cord-015021-pol2qm74	3558	7	IL	IL	NNP
cord-015021-pol2qm74	3558	8	-	-	HYPH
cord-015021-pol2qm74	3558	9	t	t	NNP
cord-015021-pol2qm74	3558	10	and	and	CC
cord-015021-pol2qm74	3558	11	its	-PRON-	PRP$
cord-015021-pol2qm74	3558	12	effects	effect	NNS
cord-015021-pol2qm74	3558	13	on	on	IN
cord-015021-pol2qm74	3558	14	diarrhea	diarrhea	NN
cord-015021-pol2qm74	3558	15	during	during	IN
cord-015021-pol2qm74	3558	16	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	3558	17	shock	shock	NN
cord-015021-pol2qm74	3558	18	.	.	.
cord-015021-pol2qm74	3559	1	CD-1	CD-1	NNP
cord-015021-pol2qm74	3559	2	mice	mouse	NNS
cord-015021-pol2qm74	3559	3	were	be	VBD
cord-015021-pol2qm74	3559	4	randomized	randomize	VBN
cord-015021-pol2qm74	3559	5	to	to	IN
cord-015021-pol2qm74	3559	6	15	15	CD
cord-015021-pol2qm74	3559	7	mg	mg	NNP
cord-015021-pol2qm74	3559	8	/	/	SYM
cord-015021-pol2qm74	3559	9	kg	kg	NNP
cord-015021-pol2qm74	3559	10	E.coli	E.coli	NNS
cord-015021-pol2qm74	3559	11	0111	0111	CD
cord-015021-pol2qm74	3559	12	:	:	:
cord-015021-pol2qm74	3559	13	B4	B4	NNP
cord-015021-pol2qm74	3559	14	LPS	LPS	NNP
cord-015021-pol2qm74	3559	15	or	or	CC
cord-015021-pol2qm74	3559	16	saline	saline	NN
cord-015021-pol2qm74	3559	17	infusion	infusion	NN
cord-015021-pol2qm74	3559	18	(	(	-LRB-
cord-015021-pol2qm74	3559	19	I.P.	I.P.	NNP
cord-015021-pol2qm74	3559	20	or	or	CC
cord-015021-pol2qm74	3559	21	I.V.	I.V.	NNP
cord-015021-pol2qm74	3559	22	)	)	-RRB-
cord-015021-pol2qm74	3559	23	.	.	.
cord-015021-pol2qm74	3560	1	Diarrhea	diarrhea	NN
cord-015021-pol2qm74	3560	2	invariably	invariably	RB
cord-015021-pol2qm74	3560	3	occurred	occur	VBD
cord-015021-pol2qm74	3560	4	following	follow	VBG
cord-015021-pol2qm74	3560	5	LPS	LPS	NNP
cord-015021-pol2qm74	3560	6	infusion	infusion	NN
cord-015021-pol2qm74	3560	7	.	.	.
cord-015021-pol2qm74	3561	1	Mice	mouse	NNS
cord-015021-pol2qm74	3561	2	were	be	VBD
cord-015021-pol2qm74	3561	3	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	3561	4	at	at	IN
cord-015021-pol2qm74	3561	5	0	0	CD
cord-015021-pol2qm74	3561	6	,	,	,
cord-015021-pol2qm74	3561	7	30	30	CD
cord-015021-pol2qm74	3561	8	'	'	NNS
cord-015021-pol2qm74	3561	9	,	,	,
cord-015021-pol2qm74	3561	10	lh	lh	NNP
cord-015021-pol2qm74	3561	11	,	,	,
cord-015021-pol2qm74	3561	12	2.5h	2.5h	CD
cord-015021-pol2qm74	3561	13	,	,	,
cord-015021-pol2qm74	3561	14	4h	4h	CD
cord-015021-pol2qm74	3561	15	,	,	,
cord-015021-pol2qm74	3561	16	6h	6h	NNP
cord-015021-pol2qm74	3561	17	,	,	,
cord-015021-pol2qm74	3561	18	12h	12h	CD
cord-015021-pol2qm74	3561	19	,	,	,
cord-015021-pol2qm74	3561	20	and	and	CC
cord-015021-pol2qm74	3561	21	24h	24h	NNS
cord-015021-pol2qm74	3561	22	(	(	-LRB-
cord-015021-pol2qm74	3561	23	3	3	CD
cord-015021-pol2qm74	3561	24	mice	mouse	NNS
cord-015021-pol2qm74	3561	25	/	/	SYM
cord-015021-pol2qm74	3561	26	group	group	NN
cord-015021-pol2qm74	3561	27	/	/	SYM
cord-015021-pol2qm74	3561	28	time	time	NN
cord-015021-pol2qm74	3561	29	-	-	HYPH
cord-015021-pol2qm74	3561	30	point	point	NN
cord-015021-pol2qm74	3561	31	)	)	-RRB-
cord-015021-pol2qm74	3561	32	.	.	.
cord-015021-pol2qm74	3562	1	The	the	DT
cord-015021-pol2qm74	3562	2	small	small	JJ
cord-015021-pol2qm74	3562	3	bowel	bowel	NN
cord-015021-pol2qm74	3562	4	was	be	VBD
cord-015021-pol2qm74	3562	5	compressed	compress	VBN
cord-015021-pol2qm74	3562	6	and	and	CC
cord-015021-pol2qm74	3562	7	the	the	DT
cord-015021-pol2qm74	3562	8	intestinal	intestinal	JJ
cord-015021-pol2qm74	3562	9	contents	content	NNS
cord-015021-pol2qm74	3562	10	were	be	VBD
cord-015021-pol2qm74	3562	11	weighed	weigh	VBN
cord-015021-pol2qm74	3562	12	and	and	CC
cord-015021-pol2qm74	3562	13	expressed	express	VBN
cord-015021-pol2qm74	3562	14	per	per	IN
cord-015021-pol2qm74	3562	15	g	g	NN
cord-015021-pol2qm74	3562	16	SB	SB	NNP
cord-015021-pol2qm74	3562	17	weight	weight	NN
cord-015021-pol2qm74	3562	18	.	.	.
cord-015021-pol2qm74	3563	1	The	the	DT
cord-015021-pol2qm74	3563	2	small	small	JJ
cord-015021-pol2qm74	3563	3	(	(	-LRB-
cord-015021-pol2qm74	3563	4	SB	SB	NNP
cord-015021-pol2qm74	3563	5	)	)	-RRB-
cord-015021-pol2qm74	3563	6	and	and	CC
cord-015021-pol2qm74	3563	7	large	large	JJ
cord-015021-pol2qm74	3563	8	bowels	bowel	NNS
cord-015021-pol2qm74	3563	9	(	(	-LRB-
cord-015021-pol2qm74	3563	10	LB	LB	NNP
cord-015021-pol2qm74	3563	11	)	)	-RRB-
cord-015021-pol2qm74	3563	12	were	be	VBD
cord-015021-pol2qm74	3563	13	eventually	eventually	RB
cord-015021-pol2qm74	3563	14	frozen	freeze	VBN
cord-015021-pol2qm74	3563	15	,	,	,
cord-015021-pol2qm74	3563	16	weighed	weigh	VBD
cord-015021-pol2qm74	3563	17	,	,	,
cord-015021-pol2qm74	3563	18	and	and	CC
cord-015021-pol2qm74	3563	19	homogenized	homogenize	VBN
cord-015021-pol2qm74	3563	20	for	for	IN
cord-015021-pol2qm74	3563	21	either	either	DT
cord-015021-pol2qm74	3563	22	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	3563	23	protein	protein	NN
cord-015021-pol2qm74	3563	24	or	or	CC
cord-015021-pol2qm74	3563	25	total	total	JJ
cord-015021-pol2qm74	3563	26	RNA	RNA	NNP
cord-015021-pol2qm74	3563	27	.	.	.
cord-015021-pol2qm74	3564	1	IL	IL	NNP
cord-015021-pol2qm74	3564	2	-	-	HYPH
cord-015021-pol2qm74	3564	3	I~	I~	NNP
cord-015021-pol2qm74	3564	4	(	(	-LRB-
cord-015021-pol2qm74	3564	5	cell	cell	NN
cord-015021-pol2qm74	3564	6	-	-	HYPH
cord-015021-pol2qm74	3564	7	associated	associate	VBN
cord-015021-pol2qm74	3564	8	agonist	agonist	NN
cord-015021-pol2qm74	3564	9	)	)	-RRB-
cord-015021-pol2qm74	3564	10	was	be	VBD
cord-015021-pol2qm74	3564	11	measured	measure	VBN
cord-015021-pol2qm74	3564	12	with	with	IN
cord-015021-pol2qm74	3564	13	a	a	DT
cord-015021-pol2qm74	3564	14	radioimmunoassay	radioimmunoassay	JJ
cord-015021-pol2qm74	3564	15	specific	specific	JJ
cord-015021-pol2qm74	3564	16	for	for	IN
cord-015021-pol2qm74	3564	17	mouse	mouse	NN
cord-015021-pol2qm74	3564	18	IL	IL	NNP
cord-015021-pol2qm74	3564	19	-	-	HYPH
cord-015021-pol2qm74	3564	20	l~	l~	XX
cord-015021-pol2qm74	3565	1	(	(	-LRB-
cord-015021-pol2qm74	3565	2	detection	detection	NN
cord-015021-pol2qm74	3565	3	limit	limit	NN
cord-015021-pol2qm74	3565	4	100	100	CD
cord-015021-pol2qm74	3565	5	pg	pg	NN
cord-015021-pol2qm74	3565	6	/	/	SYM
cord-015021-pol2qm74	3565	7	mL	mL	NNP
cord-015021-pol2qm74	3565	8	)	)	-RRB-
cord-015021-pol2qm74	3565	9	and	and	CC
cord-015021-pol2qm74	3565	10	expressed	express	VBD
cord-015021-pol2qm74	3565	11	as	as	IN
cord-015021-pol2qm74	3565	12	ng	ng	NNP
cord-015021-pol2qm74	3565	13	/	/	SYM
cord-015021-pol2qm74	3565	14	g	g	NN
cord-015021-pol2qm74	3565	15	weight	weight	NN
cord-015021-pol2qm74	3565	16	+	+	CC
cord-015021-pol2qm74	3565	17	SEM	sem	NN
cord-015021-pol2qm74	3565	18	(	(	-LRB-
cord-015021-pol2qm74	3565	19	lowest	low	JJS
cord-015021-pol2qm74	3565	20	detectable	detectable	JJ
cord-015021-pol2qm74	3565	21	amount	amount	NN
cord-015021-pol2qm74	3565	22	1	1	CD
cord-015021-pol2qm74	3565	23	ng	ng	NN
cord-015021-pol2qm74	3565	24	/	/	SYM
cord-015021-pol2qm74	3565	25	gWT	gWT	NNP
cord-015021-pol2qm74	3565	26	)	)	-RRB-
cord-015021-pol2qm74	3565	27	.	.	.
cord-015021-pol2qm74	3566	1	Northern	northern	JJ
cord-015021-pol2qm74	3566	2	analysis	analysis	NN
cord-015021-pol2qm74	3566	3	of	of	IN
cord-015021-pol2qm74	3566	4	total	total	JJ
cord-015021-pol2qm74	3566	5	RNA	RNA	NNP
cord-015021-pol2qm74	3566	6	and	and	CC
cord-015021-pol2qm74	3566	7	in	in	IN
cord-015021-pol2qm74	3566	8	sfu	sfu	NNP
cord-015021-pol2qm74	3566	9	hybridization	hybridization	NN
cord-015021-pol2qm74	3566	10	of	of	IN
cord-015021-pol2qm74	3566	11	paraformaldehyde	paraformaldehyde	NNP
cord-015021-pol2qm74	3566	12	-	-	HYPH
cord-015021-pol2qm74	3566	13	fixed	fix	VBN
cord-015021-pol2qm74	3566	14	frozen	frozen	JJ
cord-015021-pol2qm74	3566	15	tissue	tissue	NN
cord-015021-pol2qm74	3566	16	were	be	VBD
cord-015021-pol2qm74	3566	17	done	do	VBN
cord-015021-pol2qm74	3566	18	with	with	IN
cord-015021-pol2qm74	3566	19	[	[	-LRB-
cord-015021-pol2qm74	3566	20	0~-32p]-Iabeled	0~-32p]-iabeled	CD
cord-015021-pol2qm74	3566	21	mouse	mouse	NN
cord-015021-pol2qm74	3566	22	IL	IL	NNP
cord-015021-pol2qm74	3566	23	-	-	HYPH
cord-015021-pol2qm74	3566	24	lc~	lc~	NN
cord-015021-pol2qm74	3566	25	cDNA	cdna	NN
cord-015021-pol2qm74	3566	26	probes	probe	NNS
cord-015021-pol2qm74	3566	27	.	.	.
cord-015021-pol2qm74	3567	1	Only	only	RB
cord-015021-pol2qm74	3567	2	SB	SB	NNP
cord-015021-pol2qm74	3567	3	had	have	VBD
cord-015021-pol2qm74	3567	4	IL	IL	NNP
cord-015021-pol2qm74	3567	5	-	-	HYPH
cord-015021-pol2qm74	3567	6	I~	I~	NNP
cord-015021-pol2qm74	3567	7	constitutively	constitutively	RB
cord-015021-pol2qm74	3567	8	present	present	JJ
cord-015021-pol2qm74	3567	9	(	(	-LRB-
cord-015021-pol2qm74	3567	10	6.2	6.2	CD
cord-015021-pol2qm74	3567	11	+	+	SYM
cord-015021-pol2qm74	3567	12	1.6	1.6	CD
cord-015021-pol2qm74	3567	13	ng	ng	NN
cord-015021-pol2qm74	3567	14	/	/	SYM
cord-015021-pol2qm74	3567	15	gWT	gWT	NNP
cord-015021-pol2qm74	3567	16	)	)	-RRB-
cord-015021-pol2qm74	3567	17	.	.	.
cord-015021-pol2qm74	3568	1	LPS	LPS	NNP
cord-015021-pol2qm74	3568	2	I.P.	I.P.	NNP
cord-015021-pol2qm74	3568	3	or	or	CC
cord-015021-pol2qm74	3568	4	I.V.	I.V.	NNP
cord-015021-pol2qm74	3568	5	induced	induce	VBD
cord-015021-pol2qm74	3568	6	elevation	elevation	NN
cord-015021-pol2qm74	3568	7	of	of	IN
cord-015021-pol2qm74	3568	8	IL	IL	NNP
cord-015021-pol2qm74	3568	9	-	-	HYPH
cord-015021-pol2qm74	3568	10	lc¢	lc¢	NN
cord-015021-pol2qm74	3568	11	in	in	IN
cord-015021-pol2qm74	3568	12	both	both	DT
cord-015021-pol2qm74	3568	13	organs	organ	NNS
cord-015021-pol2qm74	3568	14	in	in	IN
cord-015021-pol2qm74	3568	15	a	a	DT
cord-015021-pol2qm74	3568	16	biphasic	biphasic	JJ
cord-015021-pol2qm74	3568	17	pattern	pattern	NN
cord-015021-pol2qm74	3568	18	;	;	:
cord-015021-pol2qm74	3568	19	LPS	LPS	NNP
cord-015021-pol2qm74	3568	20	I.V.	I.V.	NNP
cord-015021-pol2qm74	3568	21	induced	induce	VBN
cord-015021-pol2qm74	3569	1	3-fold	3-fold	CD
cord-015021-pol2qm74	3569	2	more	more	JJR
cord-015021-pol2qm74	3569	3	IL	IL	NNP
cord-015021-pol2qm74	3569	4	-	-	HYPH
cord-015021-pol2qm74	3569	5	I~	I~	NNP
cord-015021-pol2qm74	3569	6	than	than	IN
cord-015021-pol2qm74	3570	1	LPS	LPS	NNP
cord-015021-pol2qm74	3570	2	I.P.	I.P.	NNP
cord-015021-pol2qm74	3570	3	Following	follow	VBG
cord-015021-pol2qm74	3570	4	LPS	LPS	NNP
cord-015021-pol2qm74	3570	5	I.P.	I.P.	NNP
cord-015021-pol2qm74	3570	6	,	,	,
cord-015021-pol2qm74	3570	7	IL	IL	NNP
cord-015021-pol2qm74	3570	8	-	-	HYPH
cord-015021-pol2qm74	3570	9	I~	I~	NNP
cord-015021-pol2qm74	3570	10	in	in	IN
cord-015021-pol2qm74	3570	11	SB	SB	NNP
cord-015021-pol2qm74	3570	12	was	be	VBD
cord-015021-pol2qm74	3570	13	19.2	19.2	CD
cord-015021-pol2qm74	3570	14	+	+	SYM
cord-015021-pol2qm74	3570	15	0.6	0.6	CD
cord-015021-pol2qm74	3570	16	ng	ng	NN
cord-015021-pol2qm74	3570	17	/	/	SYM
cord-015021-pol2qm74	3570	18	gWT	gWT	NNS
cord-015021-pol2qm74	3570	19	at	at	IN
cord-015021-pol2qm74	3570	20	lh	lh	NNP
cord-015021-pol2qm74	3570	21	,	,	,
cord-015021-pol2qm74	3570	22	reached	reach	VBD
cord-015021-pol2qm74	3570	23	maximal	maximal	JJ
cord-015021-pol2qm74	3570	24	levels	level	NNS
cord-015021-pol2qm74	3570	25	at	at	IN
cord-015021-pol2qm74	3570	26	2.5h	2.5h	CD
cord-015021-pol2qm74	3570	27	(	(	-LRB-
cord-015021-pol2qm74	3570	28	31.8	31.8	CD
cord-015021-pol2qm74	3570	29	-+	-+	NNP
cord-015021-pol2qm74	3570	30	0.5	0.5	CD
cord-015021-pol2qm74	3570	31	ng	ng	NN
cord-015021-pol2qm74	3570	32	/	/	SYM
cord-015021-pol2qm74	3570	33	gW	gw	NN
cord-015021-pol2qm74	3570	34	-	-	:
cord-015021-pol2qm74	3570	35	I	i	NN
cord-015021-pol2qm74	3570	36	)	)	-RRB-
cord-015021-pol2qm74	3570	37	and	and	CC
cord-015021-pol2qm74	3570	38	returned	return	VBD
cord-015021-pol2qm74	3570	39	to	to	IN
cord-015021-pol2qm74	3570	40	baseline	baseline	NN
cord-015021-pol2qm74	3570	41	at	at	IN
cord-015021-pol2qm74	3570	42	24h	24h	NNS
cord-015021-pol2qm74	3570	43	.	.	.
cord-015021-pol2qm74	3571	1	Saline	Saline	NNP
cord-015021-pol2qm74	3571	2	controls	control	NNS
cord-015021-pol2qm74	3571	3	maintained	maintain	VBD
cord-015021-pol2qm74	3571	4	their	-PRON-	PRP$
cord-015021-pol2qm74	3571	5	constitutive	constitutive	JJ
cord-015021-pol2qm74	3571	6	IL	IL	NNP
cord-015021-pol2qm74	3571	7	-	-	HYPH
cord-015021-pol2qm74	3571	8	I~	I~	NNP
cord-015021-pol2qm74	3571	9	levels	level	NNS
cord-015021-pol2qm74	3571	10	.	.	.
cord-015021-pol2qm74	3572	1	SB	SB	NNP
cord-015021-pol2qm74	3572	2	had	have	VBD
cord-015021-pol2qm74	3572	3	2fold	2fold	CD
cord-015021-pol2qm74	3572	4	more	more	JJR
cord-015021-pol2qm74	3572	5	IL-1	IL-1	NNP
cord-015021-pol2qm74	3572	6	¢	¢	NNP
cord-015021-pol2qm74	3572	7	than	than	IN
cord-015021-pol2qm74	3572	8	LB	LB	NNP
cord-015021-pol2qm74	3572	9	and	and	CC
cord-015021-pol2qm74	3572	10	identical	identical	JJ
cord-015021-pol2qm74	3572	11	kinetics	kinetic	NNS
cord-015021-pol2qm74	3572	12	,	,	,
cord-015021-pol2qm74	3572	13	but	but	CC
cord-015021-pol2qm74	3572	14	LB	LB	NNP
cord-015021-pol2qm74	3572	15	showed	show	VBD
cord-015021-pol2qm74	3572	16	a	a	DT
cord-015021-pol2qm74	3572	17	clearer	clear	JJR
cord-015021-pol2qm74	3572	18	doseresponse	doseresponse	NN
cord-015021-pol2qm74	3572	19	.	.	.
cord-015021-pol2qm74	3573	1	Northern	northern	JJ
cord-015021-pol2qm74	3573	2	analysis	analysis	NN
cord-015021-pol2qm74	3573	3	of	of	IN
cord-015021-pol2qm74	3573	4	SB	SB	NNP
cord-015021-pol2qm74	3573	5	-	-	HYPH
cord-015021-pol2qm74	3573	6	total	total	NNP
cord-015021-pol2qm74	3573	7	RNA	RNA	NNP
cord-015021-pol2qm74	3573	8	showed	show	VBD
cord-015021-pol2qm74	3573	9	induction	induction	NN
cord-015021-pol2qm74	3573	10	of	of	IN
cord-015021-pol2qm74	3573	11	IL	IL	NNP
cord-015021-pol2qm74	3573	12	-	-	HYPH
cord-015021-pol2qm74	3573	13	I~	I~	NNP
cord-015021-pol2qm74	3573	14	mRNA	mrna	NN
cord-015021-pol2qm74	3573	15	by	by	IN
cord-015021-pol2qm74	3573	16	LPS	LPS	NNP
cord-015021-pol2qm74	3573	17	in	in	IN
cord-015021-pol2qm74	3573	18	correlation	correlation	NN
cord-015021-pol2qm74	3573	19	with	with	IN
cord-015021-pol2qm74	3573	20	IL	IL	NNP
cord-015021-pol2qm74	3573	21	-	-	HYPH
cord-015021-pol2qm74	3573	22	lc¢	lc¢	NN
cord-015021-pol2qm74	3573	23	kinetics	kinetic	NNS
cord-015021-pol2qm74	3573	24	.	.	.
cord-015021-pol2qm74	3574	1	IL	IL	NNP
cord-015021-pol2qm74	3574	2	-	-	HYPH
cord-015021-pol2qm74	3574	3	I~	I~	NNP
cord-015021-pol2qm74	3575	1	mRNA	mrna	NN
cord-015021-pol2qm74	3575	2	producing	produce	VBG
cord-015021-pol2qm74	3575	3	cells	cell	NNS
cord-015021-pol2qm74	3575	4	were	be	VBD
cord-015021-pol2qm74	3575	5	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	3575	6	cells	cell	NNS
cord-015021-pol2qm74	3575	7	in	in	IN
cord-015021-pol2qm74	3575	8	the	the	DT
cord-015021-pol2qm74	3575	9	lamina	lamina	JJ
cord-015021-pol2qm74	3575	10	propda	propda	NNP
cord-015021-pol2qm74	3575	11	and	and	CC
cord-015021-pol2qm74	3575	12	epithelial	epithelial	JJ
cord-015021-pol2qm74	3575	13	cells	cell	NNS
cord-015021-pol2qm74	3575	14	at	at	IN
cord-015021-pol2qm74	3575	15	the	the	DT
cord-015021-pol2qm74	3575	16	bottom	bottom	NN
cord-015021-pol2qm74	3575	17	of	of	IN
cord-015021-pol2qm74	3575	18	the	the	DT
cord-015021-pol2qm74	3575	19	crypts	crypt	NNS
cord-015021-pol2qm74	3575	20	of	of	IN
cord-015021-pol2qm74	3575	21	Ueberkuhn	Ueberkuhn	NNP
cord-015021-pol2qm74	3575	22	.	.	.
cord-015021-pol2qm74	3576	1	Mucus	mucus	NN
cord-015021-pol2qm74	3576	2	and	and	CC
cord-015021-pol2qm74	3576	3	fluid	fluid	NN
cord-015021-pol2qm74	3576	4	were	be	VBD
cord-015021-pol2qm74	3576	5	increased	increase	VBN
cord-015021-pol2qm74	3576	6	in	in	IN
cord-015021-pol2qm74	3576	7	the	the	DT
cord-015021-pol2qm74	3576	8	small	small	JJ
cord-015021-pol2qm74	3576	9	bowel	bowel	NN
cord-015021-pol2qm74	3576	10	post	post	NN
cord-015021-pol2qm74	3576	11	-	-	JJ
cord-015021-pol2qm74	3576	12	LPS	lp	NNS
cord-015021-pol2qm74	3576	13	in	in	IN
cord-015021-pol2qm74	3576	14	correlation	correlation	NN
cord-015021-pol2qm74	3576	15	with	with	IN
cord-015021-pol2qm74	3576	16	intestinal	intestinal	JJ
cord-015021-pol2qm74	3576	17	IL	IL	NNP
cord-015021-pol2qm74	3576	18	-	-	HYPH
cord-015021-pol2qm74	3576	19	lc~	lc~	NN
cord-015021-pol2qm74	3576	20	kinetics	kinetic	NNS
cord-015021-pol2qm74	3576	21	(	(	-LRB-
cord-015021-pol2qm74	3576	22	R2=0.9	R2=0.9	NNP
cord-015021-pol2qm74	3576	23	)	)	-RRB-
cord-015021-pol2qm74	3576	24	.	.	.
cord-015021-pol2qm74	3577	1	Separate	separate	JJ
cord-015021-pol2qm74	3577	2	mice	mouse	NNS
cord-015021-pol2qm74	3577	3	were	be	VBD
cord-015021-pol2qm74	3577	4	pretreated	pretreate	VBN
cord-015021-pol2qm74	3577	5	with	with	IN
cord-015021-pol2qm74	3577	6	saline	saline	NN
cord-015021-pol2qm74	3577	7	I.P.	I.P.	NNP
cord-015021-pol2qm74	3577	8	orthe	orthe	NN
cord-015021-pol2qm74	3577	9	IL-1	IL-1	NNP
cord-015021-pol2qm74	3577	10	receptor	receptor	NN
cord-015021-pol2qm74	3577	11	antagonist	antagonist	NN
cord-015021-pol2qm74	3577	12	(	(	-LRB-
cord-015021-pol2qm74	3577	13	IRAP	IRAP	NNP
cord-015021-pol2qm74	3577	14	,	,	,
cord-015021-pol2qm74	3577	15	30	30	CD
cord-015021-pol2qm74	3577	16	mg	mg	NN
cord-015021-pol2qm74	3577	17	/	/	SYM
cord-015021-pol2qm74	3577	18	kg	kg	NNP
cord-015021-pol2qm74	3577	19	bolus	bolus	NN
cord-015021-pol2qm74	3577	20	I.P.	I.P.	NNP
cord-015021-pol2qm74	3577	21	)	)	-RRB-
cord-015021-pol2qm74	3577	22	and	and	CC
cord-015021-pol2qm74	3577	23	were	be	VBD
cord-015021-pol2qm74	3577	24	challenged	challenge	VBN
cord-015021-pol2qm74	3577	25	20	20	CD
cord-015021-pol2qm74	3577	26	rain	rain	NN
cord-015021-pol2qm74	3577	27	later	later	RB
cord-015021-pol2qm74	3577	28	with	with	IN
cord-015021-pol2qm74	3577	29	1.5	1.5	CD
cord-015021-pol2qm74	3577	30	mg	mg	NNP
cord-015021-pol2qm74	3577	31	/	/	SYM
cord-015021-pol2qm74	3577	32	kg	kg	NNP
cord-015021-pol2qm74	3577	33	LPS	LPS	NNP
cord-015021-pol2qm74	3577	34	I.P.	I.P.	NNP
cord-015021-pol2qm74	3577	35	or	or	CC
cord-015021-pol2qm74	3577	36	saline	saline	JJ
cord-015021-pol2qm74	3577	37	I.P.	I.P.	NNP
cord-015021-pol2qm74	3577	38	Specific	specific	JJ
cord-015021-pol2qm74	3577	39	blockade	blockade	NN
cord-015021-pol2qm74	3577	40	of	of	IN
cord-015021-pol2qm74	3577	41	IL-1	IL-1	NNP
cord-015021-pol2qm74	3577	42	by	by	IN
cord-015021-pol2qm74	3577	43	IRAP	IRAP	NNP
cord-015021-pol2qm74	3577	44	decreased	decrease	VBD
cord-015021-pol2qm74	3577	45	intestinal	intestinal	JJ
cord-015021-pol2qm74	3577	46	secretion	secretion	NN
cord-015021-pol2qm74	3577	47	at	at	IN
cord-015021-pol2qm74	3577	48	4h	4h	CD
cord-015021-pol2qm74	3577	49	and	and	CC
cord-015021-pol2qm74	3577	50	6h	6h	NNP
cord-015021-pol2qm74	3577	51	post	post	JJ
cord-015021-pol2qm74	3577	52	-	-	JJ
cord-015021-pol2qm74	3577	53	LPS	lps	JJ
cord-015021-pol2qm74	3577	54	challenge	challenge	NN
cord-015021-pol2qm74	3577	55	(	(	-LRB-
cord-015021-pol2qm74	3578	1	p	p	NN
cord-015021-pol2qm74	3578	2	<	<	XX
cord-015021-pol2qm74	3578	3	_	_	NNP
cord-015021-pol2qm74	3578	4	.	.	.
cord-015021-pol2qm74	3579	1	0.05	0.05	CD
cord-015021-pol2qm74	3579	2	,	,	,
cord-015021-pol2qm74	3579	3	Student's	Student's	NNP
cord-015021-pol2qm74	3579	4	-	-	HYPH
cord-015021-pol2qm74	3579	5	t	t	NN
cord-015021-pol2qm74	3579	6	-	-	HYPH
cord-015021-pol2qm74	3579	7	test	test	NN
cord-015021-pol2qm74	3579	8	)	)	-RRB-
cord-015021-pol2qm74	3579	9	.	.	.
cord-015021-pol2qm74	3580	1	These	these	DT
cord-015021-pol2qm74	3580	2	data	datum	NNS
cord-015021-pol2qm74	3580	3	indicate	indicate	VBP
cord-015021-pol2qm74	3580	4	that	that	IN
cord-015021-pol2qm74	3580	5	local	local	JJ
cord-015021-pol2qm74	3580	6	(	(	-LRB-
cord-015021-pol2qm74	3580	7	intrinsic	intrinsic	JJ
cord-015021-pol2qm74	3580	8	)	)	-RRB-
cord-015021-pol2qm74	3580	9	intestinal	intestinal	JJ
cord-015021-pol2qm74	3580	10	IL	IL	NNP
cord-015021-pol2qm74	3580	11	-	-	HYPH
cord-015021-pol2qm74	3580	12	I~	I~	NNP
cord-015021-pol2qm74	3580	13	mediates	mediate	VBZ
cord-015021-pol2qm74	3580	14	sepsis	sepsis	NN
cord-015021-pol2qm74	3580	15	-	-	HYPH
cord-015021-pol2qm74	3580	16	induced	induce	VBN
cord-015021-pol2qm74	3580	17	intestinal	intestinal	JJ
cord-015021-pol2qm74	3580	18	changes	change	NNS
cord-015021-pol2qm74	3580	19	.	.	.
cord-015021-pol2qm74	3581	1	Inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3581	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	3581	3	initiate	initiate	VBP
cord-015021-pol2qm74	3581	4	the	the	DT
cord-015021-pol2qm74	3581	5	host	host	NN
cord-015021-pol2qm74	3581	6	response	response	NN
cord-015021-pol2qm74	3581	7	to	to	IN
cord-015021-pol2qm74	3581	8	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	3581	9	,	,	,
cord-015021-pol2qm74	3581	10	causing	cause	VBG
cord-015021-pol2qm74	3581	11	severe	severe	JJ
cord-015021-pol2qm74	3581	12	physiological	physiological	JJ
cord-015021-pol2qm74	3581	13	and	and	CC
cord-015021-pol2qm74	3581	14	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	3581	15	changes	change	NNS
cord-015021-pol2qm74	3581	16	which	which	WDT
cord-015021-pol2qm74	3581	17	may	may	MD
cord-015021-pol2qm74	3581	18	lead	lead	VB
cord-015021-pol2qm74	3581	19	to	to	IN
cord-015021-pol2qm74	3581	20	septic	septic	JJ
cord-015021-pol2qm74	3581	21	shock	shock	NN
cord-015021-pol2qm74	3581	22	.	.	.
cord-015021-pol2qm74	3582	1	Among	among	IN
cord-015021-pol2qm74	3582	2	the	the	DT
cord-015021-pol2qm74	3582	3	regulatory	regulatory	JJ
cord-015021-pol2qm74	3582	4	systems	system	NNS
cord-015021-pol2qm74	3582	5	that	that	WDT
cord-015021-pol2qm74	3582	6	play	play	VBP
cord-015021-pol2qm74	3582	7	an	an	DT
cord-015021-pol2qm74	3582	8	important	important	JJ
cord-015021-pol2qm74	3582	9	rote	rote	NN
cord-015021-pol2qm74	3582	10	in	in	IN
cord-015021-pol2qm74	3582	11	controlling	control	VBG
cord-015021-pol2qm74	3582	12	host	host	NN
cord-015021-pol2qm74	3582	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3582	14	responses	response	NNS
cord-015021-pol2qm74	3582	15	is	be	VBZ
cord-015021-pol2qm74	3582	16	the	the	DT
cord-015021-pol2qm74	3582	17	pituitary	pituitary	NN
cord-015021-pol2qm74	3582	18	.	.	.
cord-015021-pol2qm74	3583	1	It	-PRON-	PRP
cord-015021-pol2qm74	3583	2	has	have	VBZ
cord-015021-pol2qm74	3583	3	been	be	VBN
cord-015021-pol2qm74	3583	4	known	know	VBN
cord-015021-pol2qm74	3583	5	for	for	IN
cord-015021-pol2qm74	3583	6	many	many	JJ
cord-015021-pol2qm74	3583	7	years	year	NNS
cord-015021-pol2qm74	3583	8	for	for	IN
cord-015021-pol2qm74	3583	9	example	example	NN
cord-015021-pol2qm74	3583	10	,	,	,
cord-015021-pol2qm74	3583	11	that	that	IN
cord-015021-pol2qm74	3583	12	hypophysectomized	hypophysectomize	VBN
cord-015021-pol2qm74	3583	13	animals	animal	NNS
cord-015021-pol2qm74	3583	14	are	be	VBP
cord-015021-pol2qm74	3583	15	extremely	extremely	RB
cord-015021-pol2qm74	3583	16	sensitive	sensitive	JJ
cord-015021-pol2qm74	3583	17	to	to	IN
cord-015021-pol2qm74	3583	18	LPS	LPS	NNP
cord-015021-pol2qm74	3583	19	lethality	lethality	NN
cord-015021-pol2qm74	3583	20	.	.	.
cord-015021-pol2qm74	3584	1	While	while	IN
cord-015021-pol2qm74	3584	2	investigating	investigate	VBG
cord-015021-pol2qm74	3584	3	the	the	DT
cord-015021-pol2qm74	3584	4	possibility	possibility	NN
cord-015021-pol2qm74	3584	5	that	that	IN
cord-015021-pol2qm74	3584	6	protective	protective	JJ
cord-015021-pol2qm74	3584	7	,	,	,
cord-015021-pol2qm74	3584	8	pituitary	pituitary	JJ
cord-015021-pol2qm74	3584	9	mediators	mediator	NNS
cord-015021-pol2qm74	3584	10	might	may	MD
cord-015021-pol2qm74	3584	11	explain	explain	VB
cord-015021-pol2qm74	3584	12	this	this	DT
cord-015021-pol2qm74	3584	13	phenomenon	phenomenon	NN
cord-015021-pol2qm74	3584	14	,	,	,
cord-015021-pol2qm74	3584	15	we	-PRON-	PRP
cord-015021-pol2qm74	3584	16	identified	identify	VBD
cord-015021-pol2qm74	3584	17	the	the	DT
cord-015021-pol2qm74	3584	18	cytoldne	cytoldne	NNP
cord-015021-pol2qm74	3584	19	MIF	MIF	NNP
cord-015021-pol2qm74	3584	20	to	to	TO
cord-015021-pol2qm74	3584	21	be	be	VB
cord-015021-pol2qm74	3584	22	a	a	DT
cord-015021-pol2qm74	3584	23	specific	specific	JJ
cord-015021-pol2qm74	3584	24	secretory	secretory	JJ
cord-015021-pol2qm74	3584	25	product	product	NN
cord-015021-pol2qm74	3584	26	produced	produce	VBN
cord-015021-pol2qm74	3584	27	by	by	IN
cord-015021-pol2qm74	3584	28	pituitary	pituitary	JJ
cord-015021-pol2qm74	3584	29	cells	cell	NNS
cord-015021-pol2qm74	3584	30	in	in	IN
cord-015021-pol2qm74	3584	31	vitro	vitro	FW
cord-015021-pol2qm74	3584	32	and	and	CC
cord-015021-pol2qm74	3584	33	in	in	IN
cord-015021-pol2qm74	3584	34	vivo	vivo	NN
cord-015021-pol2qm74	3584	35	after	after	IN
cord-015021-pol2qm74	3584	36	LPS	LPS	NNP
cord-015021-pol2qm74	3584	37	challenge	challenge	NN
cord-015021-pol2qm74	3584	38	.	.	.
cord-015021-pol2qm74	3585	1	Analysis	analysis	NN
cord-015021-pol2qm74	3585	2	of	of	IN
cord-015021-pol2qm74	3585	3	serum	serum	NN
cord-015021-pol2qm74	3585	4	MIF	MIF	NNP
cord-015021-pol2qm74	3585	5	levels	level	NNS
cord-015021-pol2qm74	3585	6	in	in	IN
cord-015021-pol2qm74	3585	7	control	control	NN
cord-015021-pol2qm74	3585	8	,	,	,
cord-015021-pol2qm74	3585	9	T	t	NN
cord-015021-pol2qm74	3585	10	-	-	HYPH
cord-015021-pol2qm74	3585	11	cell	cell	NN
cord-015021-pol2qm74	3585	12	deficient	deficient	JJ
cord-015021-pol2qm74	3585	13	(	(	-LRB-
cord-015021-pol2qm74	3585	14	nude	nude	NNP
cord-015021-pol2qm74	3585	15	)	)	-RRB-
cord-015021-pol2qm74	3585	16	,	,	,
cord-015021-pol2qm74	3585	17	and	and	CC
cord-015021-pol2qm74	3585	18	hypophysectomized	hypophysectomized	JJ
cord-015021-pol2qm74	3585	19	mice	mouse	NNS
cord-015021-pol2qm74	3585	20	revealed	reveal	VBD
cord-015021-pol2qm74	3585	21	that	that	IN
cord-015021-pol2qm74	3585	22	pituitary	pituitary	NN
cord-015021-pol2qm74	3585	23	-	-	HYPH
cord-015021-pol2qm74	3585	24	derived	derive	VBN
cord-015021-pol2qm74	3585	25	MIF	MIF	NNP
cord-015021-pol2qm74	3585	26	contributes	contribute	VBZ
cord-015021-pol2qm74	3585	27	significantly	significantly	RB
cord-015021-pol2qm74	3585	28	to	to	IN
cord-015021-pol2qm74	3585	29	the	the	DT
cord-015021-pol2qm74	3585	30	rise	rise	NN
cord-015021-pol2qm74	3585	31	in	in	IN
cord-015021-pol2qm74	3585	32	serum	serum	NN
cord-015021-pol2qm74	3585	33	MIF	MIF	NNP
cord-015021-pol2qm74	3585	34	that	that	WDT
cord-015021-pol2qm74	3585	35	occurs	occur	VBZ
cord-015021-pol2qm74	3585	36	after	after	IN
cord-015021-pol2qm74	3585	37	LPS	LPS	NNP
cord-015021-pol2qm74	3585	38	administration	administration	NN
cord-015021-pol2qm74	3585	39	.	.	.
cord-015021-pol2qm74	3586	1	Of	of	IN
cord-015021-pol2qm74	3586	2	note	note	NN
cord-015021-pol2qm74	3586	3	,	,	,
cord-015021-pol2qm74	3586	4	pituitary	pituitary	NN
cord-015021-pol2qm74	3586	5	MIF	MIF	NNP
cord-015021-pol2qm74	3586	6	content	content	NN
cord-015021-pol2qm74	3586	7	(	(	-LRB-
cord-015021-pol2qm74	3586	8	0.05	0.05	CD
cord-015021-pol2qm74	3586	9	%	%	NN
cord-015021-pol2qm74	3586	10	of	of	IN
cord-015021-pol2qm74	3586	11	total	total	JJ
cord-015021-pol2qm74	3586	12	pituitary	pituitary	JJ
cord-015021-pol2qm74	3586	13	protein	protein	NN
cord-015021-pol2qm74	3586	14	)	)	-RRB-
cord-015021-pol2qm74	3586	15	and	and	CC
cord-015021-pol2qm74	3586	16	peak	peak	NN
cord-015021-pol2qm74	3586	17	serum	serum	NN
cord-015021-pol2qm74	3586	18	MIF	MIF	NNP
cord-015021-pol2qm74	3586	19	levels	level	NNS
cord-015021-pol2qm74	3586	20	(	(	-LRB-
cord-015021-pol2qm74	3586	21	80	80	CD
cord-015021-pol2qm74	3586	22	-	-	SYM
cord-015021-pol2qm74	3586	23	340	340	CD
cord-015021-pol2qm74	3586	24	ng	ng	NN
cord-015021-pol2qm74	3586	25	/	/	SYM
cord-015021-pol2qm74	3586	26	ml	ml	NN
cord-015021-pol2qm74	3586	27	)	)	-RRB-
cord-015021-pol2qm74	3586	28	were	be	VBD
cord-015021-pol2qm74	3586	29	determined	determine	VBN
cord-015021-pol2qm74	3586	30	to	to	TO
cord-015021-pol2qm74	3586	31	be	be	VB
cord-015021-pol2qm74	3586	32	within	within	IN
cord-015021-pol2qm74	3586	33	the	the	DT
cord-015021-pol2qm74	3586	34	range	range	NN
cord-015021-pol2qm74	3586	35	observed	observe	VBN
cord-015021-pol2qm74	3586	36	for	for	IN
cord-015021-pol2qm74	3586	37	other	other	JJ
cord-015021-pol2qm74	3586	38	pituitary	pituitary	JJ
cord-015021-pol2qm74	3586	39	hormones	hormone	NNS
cord-015021-pol2qm74	3586	40	that	that	WDT
cord-015021-pol2qm74	3586	41	are	be	VBP
cord-015021-pol2qm74	3586	42	released	release	VBN
cord-015021-pol2qm74	3586	43	after	after	IN
cord-015021-pol2qm74	3586	44	pituitary	pituitary	JJ
cord-015021-pol2qm74	3586	45	stimulation	stimulation	NN
cord-015021-pol2qm74	3586	46	.	.	.
cord-015021-pol2qm74	3587	1	To	to	TO
cord-015021-pol2qm74	3587	2	investigate	investigate	VB
cord-015021-pol2qm74	3587	3	a	a	DT
cord-015021-pol2qm74	3587	4	possible	possible	JJ
cord-015021-pol2qm74	3587	5	beneficial	beneficial	JJ
cord-015021-pol2qm74	3587	6	role	role	NN
cord-015021-pol2qm74	3587	7	for	for	IN
cord-015021-pol2qm74	3587	8	MIF	MIF	NNP
cord-015021-pol2qm74	3587	9	in	in	IN
cord-015021-pol2qm74	3587	10	septic	septic	JJ
cord-015021-pol2qm74	3587	11	shock	shock	NN
cord-015021-pol2qm74	3587	12	,	,	,
cord-015021-pol2qm74	3587	13	we	-PRON-	PRP
cord-015021-pol2qm74	3587	14	co	co	VBD
cord-015021-pol2qm74	3587	15	-	-	VBD
cord-015021-pol2qm74	3587	16	injected	inject	VBN
cord-015021-pol2qm74	3587	17	mice	mouse	NNS
cord-015021-pol2qm74	3587	18	with	with	IN
cord-015021-pol2qm74	3587	19	purified	purify	VBN
cord-015021-pol2qm74	3587	20	,	,	,
cord-015021-pol2qm74	3587	21	recombinant	recombinant	JJ
cord-015021-pol2qm74	3587	22	murine	murine	NN
cord-015021-pol2qm74	3587	23	MIF	MIF	NNP
cord-015021-pol2qm74	3587	24	(	(	-LRB-
cord-015021-pol2qm74	3587	25	rMIF	rmif	JJ
cord-015021-pol2qm74	3587	26	)	)	-RRB-
cord-015021-pol2qm74	3587	27	together	together	RB
cord-015021-pol2qm74	3587	28	with	with	IN
cord-015021-pol2qm74	3587	29	LPS	LPS	NNP
cord-015021-pol2qm74	3587	30	(	(	-LRB-
cord-015021-pol2qm74	3587	31	15	15	CD
cord-015021-pol2qm74	3587	32	mg	mg	NNP
cord-015021-pol2qm74	3587	33	/	/	SYM
cord-015021-pol2qm74	3587	34	kg	kg	NNP
cord-015021-pol2qm74	3587	35	)	)	-RRB-
cord-015021-pol2qm74	3587	36	.	.	.
cord-015021-pol2qm74	3588	1	Surprisingly	surprisingly	RB
cord-015021-pol2qm74	3588	2	,	,	,
cord-015021-pol2qm74	3588	3	rMIF	rmif	JJ
cord-015021-pol2qm74	3588	4	markedly	markedly	RB
cord-015021-pol2qm74	3588	5	potentiated	potentiate	VBD
cord-015021-pol2qm74	3588	6	LPS	LPS	NNP
cord-015021-pol2qm74	3588	7	lethality	lethality	NN
cord-015021-pol2qm74	3588	8	compared	compare	VBN
cord-015021-pol2qm74	3588	9	to	to	TO
cord-015021-pol2qm74	3588	10	control	control	VB
cord-015021-pol2qm74	3588	11	mice	mouse	NNS
cord-015021-pol2qm74	3588	12	that	that	WDT
cord-015021-pol2qm74	3588	13	were	be	VBD
cord-015021-pol2qm74	3588	14	injected	inject	VBN
cord-015021-pol2qm74	3588	15	with	with	IN
cord-015021-pol2qm74	3588	16	LPS	LPS	NNP
cord-015021-pol2qm74	3588	17	alone	alone	JJ
cord-015021-pol2qm74	3588	18	(	(	-LRB-
cord-015021-pol2qm74	3588	19	85	85	CD
cord-015021-pol2qm74	3588	20	%	%	NN
cord-015021-pol2qm74	3588	21	vs.	vs.	CC
cord-015021-pol2qm74	3588	22	35	35	CD
cord-015021-pol2qm74	3588	23	%	%	NN
cord-015021-pol2qm74	3588	24	,	,	,
cord-015021-pol2qm74	3588	25	P	p	NN
cord-015021-pol2qm74	3588	26	=	=	SYM
cord-015021-pol2qm74	3588	27	0.003	0.003	CD
cord-015021-pol2qm74	3588	28	)	)	-RRB-
cord-015021-pol2qm74	3588	29	.	.	.
cord-015021-pol2qm74	3589	1	To	to	TO
cord-015021-pol2qm74	3589	2	confirm	confirm	VB
cord-015021-pol2qm74	3589	3	these	these	DT
cord-015021-pol2qm74	3589	4	results	result	NNS
cord-015021-pol2qm74	3589	5	,	,	,
cord-015021-pol2qm74	3589	6	mice	mouse	NNS
cord-015021-pol2qm74	3589	7	were	be	VBD
cord-015021-pol2qm74	3589	8	treated	treat	VBN
cord-015021-pol2qm74	3589	9	with	with	IN
cord-015021-pol2qm74	3589	10	anti	anti	JJ
cord-015021-pol2qm74	3589	11	-	-	JJ
cord-015021-pol2qm74	3589	12	rMIF	rmif	JJ
cord-015021-pol2qm74	3589	13	antibody	antibody	NN
cord-015021-pol2qm74	3589	14	prior	prior	RB
cord-015021-pol2qm74	3589	15	to	to	IN
cord-015021-pol2qm74	3589	16	injection	injection	NN
cord-015021-pol2qm74	3589	17	of	of	IN
cord-015021-pol2qm74	3589	18	a	a	DT
cord-015021-pol2qm74	3589	19	high	high	JJ
cord-015021-pol2qm74	3589	20	dose	dose	NN
cord-015021-pol2qm74	3589	21	of	of	IN
cord-015021-pol2qm74	3589	22	LPS	LPS	NNP
cord-015021-pol2qm74	3589	23	(	(	-LRB-
cord-015021-pol2qm74	3589	24	17.5	17.5	CD
cord-015021-pol2qm74	3589	25	mg	mg	NNP
cord-015021-pol2qm74	3589	26	/	/	SYM
cord-015021-pol2qm74	3589	27	kg	kg	NNP
cord-015021-pol2qm74	3589	28	)	)	-RRB-
cord-015021-pol2qm74	3589	29	.	.	.
cord-015021-pol2qm74	3590	1	Anti	anti	JJ
cord-015021-pol2qm74	3590	2	-	-	JJ
cord-015021-pol2qm74	3590	3	rMIF	rmif	JJ
cord-015021-pol2qm74	3590	4	antibody	antibody	NN
cord-015021-pol2qm74	3590	5	fully	fully	RB
cord-015021-pol2qm74	3590	6	protected	protect	VBD
cord-015021-pol2qm74	3590	7	mice	mouse	NNS
cord-015021-pol2qm74	3590	8	against	against	IN
cord-015021-pol2qm74	3590	9	LPS	LPS	NNP
cord-015021-pol2qm74	3590	10	lethality	lethality	NN
cord-015021-pol2qm74	3590	11	,	,	,
cord-015021-pol2qm74	3590	12	increasing	increase	VBG
cord-015021-pol2qm74	3590	13	survival	survival	NN
cord-015021-pol2qm74	3590	14	from	from	IN
cord-015021-pol2qm74	3590	15	50	50	CD
cord-015021-pol2qm74	3590	16	%	%	NN
cord-015021-pol2qm74	3590	17	to	to	TO
cord-015021-pol2qm74	3590	18	100	100	CD
cord-015021-pol2qm74	3590	19	%	%	NN
cord-015021-pol2qm74	3591	1	(	(	-LRB-
cord-015021-pol2qm74	3591	2	P	p	NN
cord-015021-pol2qm74	3591	3	=	=	SYM
cord-015021-pol2qm74	3591	4	0.0004	0.0004	CD
cord-015021-pol2qm74	3591	5	)	)	-RRB-
cord-015021-pol2qm74	3591	6	.	.	.
cord-015021-pol2qm74	3592	1	Serum	serum	NN
cord-015021-pol2qm74	3592	2	levels	level	NNS
cord-015021-pol2qm74	3592	3	of	of	IN
cord-015021-pol2qm74	3592	4	TNF,~	TNF,~	NNP
cord-015021-pol2qm74	3592	5	,	,	,
cord-015021-pol2qm74	3592	6	the	the	DT
cord-015021-pol2qm74	3592	7	first	first	JJ
cord-015021-pol2qm74	3592	8	cytokinc	cytokinc	NNP
cord-015021-pol2qm74	3592	9	that	that	WDT
cord-015021-pol2qm74	3592	10	appears	appear	VBZ
cord-015021-pol2qm74	3592	11	in	in	IN
cord-015021-pol2qm74	3592	12	the	the	DT
cord-015021-pol2qm74	3592	13	circulation	circulation	NN
cord-015021-pol2qm74	3592	14	after	after	IN
cord-015021-pol2qm74	3592	15	LPS	LPS	NNP
cord-015021-pol2qm74	3592	16	challenge	challenge	NN
cord-015021-pol2qm74	3592	17	,	,	,
cord-015021-pol2qm74	3592	18	were	be	VBD
cord-015021-pol2qm74	3592	19	reduced	reduce	VBN
cord-015021-pol2qm74	3592	20	by	by	IN
cord-015021-pol2qm74	3592	21	38.0	38.0	CD
cord-015021-pol2qm74	3592	22	_	_	NN
cord-015021-pol2qm74	3592	23	+	+	CC
cord-015021-pol2qm74	3592	24	9.5	9.5	CD
cord-015021-pol2qm74	3592	25	%	%	NN
cord-015021-pol2qm74	3592	26	in	in	IN
cord-015021-pol2qm74	3592	27	anti	anti	JJ
cord-015021-pol2qm74	3592	28	-	-	JJ
cord-015021-pol2qm74	3592	29	rMIF	rmif	JJ
cord-015021-pol2qm74	3592	30	-	-	HYPH
cord-015021-pol2qm74	3592	31	treated	treat	VBN
cord-015021-pol2qm74	3592	32	mice	mouse	NNS
cord-015021-pol2qm74	3592	33	.	.	.
cord-015021-pol2qm74	3593	1	We	-PRON-	PRP
cord-015021-pol2qm74	3593	2	conclude	conclude	VBP
cord-015021-pol2qm74	3593	3	that	that	IN
cord-015021-pol2qm74	3593	4	pituitary	pituitary	NN
cord-015021-pol2qm74	3593	5	derived	derive	VBN
cord-015021-pol2qm74	3593	6	MIF	MIF	NNP
cord-015021-pol2qm74	3593	7	contributes	contribute	VBZ
cord-015021-pol2qm74	3593	8	significantly	significantly	RB
cord-015021-pol2qm74	3593	9	to	to	IN
cord-015021-pol2qm74	3593	10	circulating	circulate	VBG
cord-015021-pol2qm74	3593	11	MIF	MIF	NNP
cord-015021-pol2qm74	3593	12	in	in	IN
cord-015021-pol2qm74	3593	13	the	the	DT
cord-015021-pol2qm74	3593	14	post	post	JJ
cord-015021-pol2qm74	3593	15	-	-	JJ
cord-015021-pol2qm74	3593	16	acute	acute	JJ
cord-015021-pol2qm74	3593	17	response	response	NN
cord-015021-pol2qm74	3593	18	in	in	IN
cord-015021-pol2qm74	3593	19	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	3593	20	and	and	CC
cord-015021-pol2qm74	3593	21	may	may	MD
cord-015021-pol2qm74	3593	22	act	act	VB
cord-015021-pol2qm74	3593	23	in	in	IN
cord-015021-pol2qm74	3593	24	concert	concert	NN
cord-015021-pol2qm74	3593	25	with	with	IN
cord-015021-pol2qm74	3593	26	other	other	JJ
cord-015021-pol2qm74	3593	27	pituitary	pituitary	JJ
cord-015021-pol2qm74	3593	28	mediators	mediator	NNS
cord-015021-pol2qm74	3593	29	to	to	TO
cord-015021-pol2qm74	3593	30	regulate	regulate	VB
cord-015021-pol2qm74	3593	31	both	both	DT
cord-015021-pol2qm74	3593	32	pro	pro	JJ
cord-015021-pol2qm74	3593	33	-	-	JJ
cord-015021-pol2qm74	3593	34	and	and	CC
cord-015021-pol2qm74	3593	35	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	3593	36	effects	effect	NNS
cord-015021-pol2qm74	3593	37	.	.	.
cord-015021-pol2qm74	3594	1	Moreover	moreover	RB
cord-015021-pol2qm74	3594	2	,	,	,
cord-015021-pol2qm74	3594	3	MIF	MIF	NNP
cord-015021-pol2qm74	3594	4	may	may	MD
cord-015021-pol2qm74	3594	5	play	play	VB
cord-015021-pol2qm74	3594	6	a	a	DT
cord-015021-pol2qm74	3594	7	critical	critical	JJ
cord-015021-pol2qm74	3594	8	regulatory	regulatory	JJ
cord-015021-pol2qm74	3594	9	role	role	NN
cord-015021-pol2qm74	3594	10	in	in	IN
cord-015021-pol2qm74	3594	11	the	the	DT
cord-015021-pol2qm74	3594	12	systemic	systemic	JJ
cord-015021-pol2qm74	3594	13	host	host	NN
cord-015021-pol2qm74	3594	14	response	response	NN
cord-015021-pol2qm74	3594	15	in	in	IN
cord-015021-pol2qm74	3594	16	septic	septic	JJ
cord-015021-pol2qm74	3594	17	shock	shock	NN
cord-015021-pol2qm74	3594	18	.	.	.
cord-015021-pol2qm74	3595	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3595	2	results	result	NNS
cord-015021-pol2qm74	3595	3	suggest	suggest	VBP
cord-015021-pol2qm74	3595	4	that	that	IN
cord-015021-pol2qm74	3595	5	anti	anti	JJ
cord-015021-pol2qm74	3595	6	-	-	JJ
cord-015021-pol2qm74	3595	7	rMIF	rmif	JJ
cord-015021-pol2qm74	3595	8	antibody	antibody	NN
cord-015021-pol2qm74	3595	9	might	may	MD
cord-015021-pol2qm74	3595	10	be	be	VB
cord-015021-pol2qm74	3595	11	of	of	IN
cord-015021-pol2qm74	3595	12	potential	potential	JJ
cord-015021-pol2qm74	3595	13	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	3595	14	use	use	NN
cord-015021-pol2qm74	3595	15	in	in	IN
cord-015021-pol2qm74	3595	16	the	the	DT
cord-015021-pol2qm74	3595	17	treatment	treatment	NN
cord-015021-pol2qm74	3595	18	of	of	IN
cord-015021-pol2qm74	3595	19	septic	septic	JJ
cord-015021-pol2qm74	3595	20	shock	shock	NN
cord-015021-pol2qm74	3595	21	.	.	.
cord-015021-pol2qm74	3596	1	Although	although	IN
cord-015021-pol2qm74	3596	2	anti	anti	JJ
cord-015021-pol2qm74	3596	3	-	-	JJ
cord-015021-pol2qm74	3596	4	Interleukin-1	interleukin-1	JJ
cord-015021-pol2qm74	3596	5	(	(	-LRB-
cord-015021-pol2qm74	3596	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	3596	7	)	)	-RRB-
cord-015021-pol2qm74	3596	8	antibodies	antibody	NNS
cord-015021-pol2qm74	3596	9	and	and	CC
cord-015021-pol2qm74	3596	10	IL-1	IL-1	NNP
cord-015021-pol2qm74	3596	11	receptor	receptor	NN
cord-015021-pol2qm74	3596	12	antagonist	antagonist	NN
cord-015021-pol2qm74	3596	13	have	have	VBP
cord-015021-pol2qm74	3596	14	been	be	VBN
cord-015021-pol2qm74	3596	15	shown	show	VBN
cord-015021-pol2qm74	3596	16	to	to	TO
cord-015021-pol2qm74	3596	17	improve	improve	VB
cord-015021-pol2qm74	3596	18	survival	survival	NN
cord-015021-pol2qm74	3596	19	in	in	IN
cord-015021-pol2qm74	3596	20	animal	animal	NN
cord-015021-pol2qm74	3596	21	models	model	NNS
cord-015021-pol2qm74	3596	22	of	of	IN
cord-015021-pol2qm74	3596	23	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	3596	24	and	and	CC
cord-015021-pol2qm74	3596	25	abrogate	abrogate	VB
cord-015021-pol2qm74	3596	26	the	the	DT
cord-015021-pol2qm74	3596	27	lethal	lethal	JJ
cord-015021-pol2qm74	3596	28	effects	effect	NNS
cord-015021-pol2qm74	3596	29	of	of	IN
cord-015021-pol2qm74	3596	30	TNF	TNF	NNP
cord-015021-pol2qm74	3596	31	,	,	,
cord-015021-pol2qm74	3596	32	the	the	DT
cord-015021-pol2qm74	3596	33	presence	presence	NN
cord-015021-pol2qm74	3596	34	of	of	IN
cord-015021-pol2qm74	3596	35	IL-1	IL-1	NNP
cord-015021-pol2qm74	3596	36	in	in	IN
cord-015021-pol2qm74	3596	37	the	the	DT
cord-015021-pol2qm74	3596	38	serum	serum	NN
cord-015021-pol2qm74	3596	39	does	do	VBZ
cord-015021-pol2qm74	3596	40	not	not	RB
cord-015021-pol2qm74	3596	41	correlate	correlate	VB
cord-015021-pol2qm74	3596	42	well	well	RB
cord-015021-pol2qm74	3596	43	with	with	IN
cord-015021-pol2qm74	3596	44	outcome	outcome	NN
cord-015021-pol2qm74	3596	45	.	.	.
cord-015021-pol2qm74	3597	1	We	-PRON-	PRP
cord-015021-pol2qm74	3597	2	hypothesized	hypothesize	VBD
cord-015021-pol2qm74	3597	3	that	that	IN
cord-015021-pol2qm74	3597	4	this	this	DT
cord-015021-pol2qm74	3597	5	may	may	MD
cord-015021-pol2qm74	3597	6	be	be	VB
cord-015021-pol2qm74	3597	7	because	because	IN
cord-015021-pol2qm74	3597	8	IL-1	IL-1	NNP
cord-015021-pol2qm74	3597	9	acts	act	VBZ
cord-015021-pol2qm74	3597	10	mainly	mainly	RB
cord-015021-pol2qm74	3597	11	in	in	IN
cord-015021-pol2qm74	3597	12	a	a	DT
cord-015021-pol2qm74	3597	13	paracrine	paracrine	JJ
cord-015021-pol2qm74	3597	14	fashion	fashion	NN
cord-015021-pol2qm74	3597	15	and	and	CC
cord-015021-pol2qm74	3597	16	is	be	VBZ
cord-015021-pol2qm74	3597	17	metabolized	metabolize	VBN
cord-015021-pol2qm74	3597	18	before	before	IN
cord-015021-pol2qm74	3597	19	it	-PRON-	PRP
cord-015021-pol2qm74	3597	20	diffuses	diffuse	VBZ
cord-015021-pol2qm74	3597	21	into	into	IN
cord-015021-pol2qm74	3597	22	the	the	DT
cord-015021-pol2qm74	3597	23	circulation	circulation	NN
cord-015021-pol2qm74	3597	24	.	.	.
cord-015021-pol2qm74	3598	1	Methods	method	NNS
cord-015021-pol2qm74	3598	2	:	:	:
cord-015021-pol2qm74	3598	3	We	-PRON-	PRP
cord-015021-pol2qm74	3598	4	measured	measure	VBD
cord-015021-pol2qm74	3598	5	the	the	DT
cord-015021-pol2qm74	3598	6	IL	IL	NNP
cord-015021-pol2qm74	3598	7	-	-	HYPH
cord-015021-pol2qm74	3598	8	I~	I~	NNP
cord-015021-pol2qm74	3598	9	mRNA	mRNA	NNP
cord-015021-pol2qm74	3598	10	expression	expression	NN
cord-015021-pol2qm74	3598	11	with	with	IN
cord-015021-pol2qm74	3598	12	the	the	DT
cord-015021-pol2qm74	3598	13	differential	differential	JJ
cord-015021-pol2qm74	3598	14	reverse	reverse	NN
cord-015021-pol2qm74	3598	15	transcription	transcription	NN
cord-015021-pol2qm74	3598	16	polymerase	polymerase	NN
cord-015021-pol2qm74	3598	17	chain	chain	NN
cord-015021-pol2qm74	3598	18	reaction	reaction	NN
cord-015021-pol2qm74	3598	19	(	(	-LRB-
cord-015021-pol2qm74	3598	20	RT	RT	NNP
cord-015021-pol2qm74	3598	21	-	-	HYPH
cord-015021-pol2qm74	3598	22	PCR	PCR	NNP
cord-015021-pol2qm74	3598	23	)	)	-RRB-
cord-015021-pol2qm74	3598	24	using	use	VBG
cord-015021-pol2qm74	3598	25	g	g	NN
cord-015021-pol2qm74	3598	26	-	-	HYPH
cord-015021-pol2qm74	3598	27	actin	actin	NN
cord-015021-pol2qm74	3598	28	as	as	IN
cord-015021-pol2qm74	3598	29	internal	internal	JJ
cord-015021-pol2qm74	3598	30	standard	standard	NN
cord-015021-pol2qm74	3598	31	in	in	IN
cord-015021-pol2qm74	3598	32	the	the	DT
cord-015021-pol2qm74	3598	33	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	3598	34	macrophages	macrophage	NNS
cord-015021-pol2qm74	3598	35	and	and	CC
cord-015021-pol2qm74	3598	36	lung	lung	NN
cord-015021-pol2qm74	3598	37	tissue	tissue	NN
cord-015021-pol2qm74	3598	38	in	in	IN
cord-015021-pol2qm74	3598	39	normal	normal	JJ
cord-015021-pol2qm74	3598	40	controls	control	NNS
cord-015021-pol2qm74	3598	41	and	and	CC
cord-015021-pol2qm74	3598	42	mice	mouse	NNS
cord-015021-pol2qm74	3598	43	after	after	IN
cord-015021-pol2qm74	3598	44	cecal	cecal	JJ
cord-015021-pol2qm74	3598	45	ligation	ligation	NN
cord-015021-pol2qm74	3598	46	and	and	CC
cord-015021-pol2qm74	3598	47	puncture	puncture	NN
cord-015021-pol2qm74	3598	48	(	(	-LRB-
cord-015021-pol2qm74	3598	49	CLP	CLP	NNP
cord-015021-pol2qm74	3598	50	)	)	-RRB-
cord-015021-pol2qm74	3598	51	.	.	.
cord-015021-pol2qm74	3599	1	CLP	CLP	NNP
cord-015021-pol2qm74	3599	2	resembles	resemble	VBZ
cord-015021-pol2qm74	3599	3	human	human	JJ
cord-015021-pol2qm74	3599	4	intra	intra	JJ
cord-015021-pol2qm74	3599	5	-	-	JJ
cord-015021-pol2qm74	3599	6	abdominal	abdominal	JJ
cord-015021-pol2qm74	3599	7	sepsis	sepsis	NN
cord-015021-pol2qm74	3599	8	in	in	IN
cord-015021-pol2qm74	3599	9	that	that	IN
cord-015021-pol2qm74	3599	10	it	-PRON-	PRP
cord-015021-pol2qm74	3599	11	is	be	VBZ
cord-015021-pol2qm74	3599	12	characterized	characterize	VBN
cord-015021-pol2qm74	3599	13	by	by	IN
cord-015021-pol2qm74	3599	14	very	very	RB
cord-015021-pol2qm74	3599	15	slight	slight	JJ
cord-015021-pol2qm74	3599	16	elevations	elevation	NNS
cord-015021-pol2qm74	3599	17	of	of	IN
cord-015021-pol2qm74	3599	18	serum	serum	NN
cord-015021-pol2qm74	3599	19	IL-1	IL-1	NNP
cord-015021-pol2qm74	3599	20	levels	level	NNS
cord-015021-pol2qm74	3599	21	.	.	.
cord-015021-pol2qm74	3600	1	Results	result	NNS
cord-015021-pol2qm74	3600	2	:	:	:
cord-015021-pol2qm74	3601	1	IL	IL	NNP
cord-015021-pol2qm74	3601	2	-	-	HYPH
cord-015021-pol2qm74	3601	3	lg	lg	NNP
cord-015021-pol2qm74	3601	4	mRNA	mRNA	NNP
cord-015021-pol2qm74	3601	5	levels	level	NNS
cord-015021-pol2qm74	3601	6	after	after	IN
cord-015021-pol2qm74	3601	7	CLP	CLP	NNP
cord-015021-pol2qm74	3601	8	are	be	VBP
cord-015021-pol2qm74	3601	9	expressed	express	VBN
cord-015021-pol2qm74	3601	10	as	as	IN
cord-015021-pol2qm74	3601	11	%	%	NN
cord-015021-pol2qm74	3601	12	of	of	IN
cord-015021-pol2qm74	3601	13	normal	normal	JJ
cord-015021-pol2qm74	3601	14	(	(	-LRB-
cord-015021-pol2qm74	3602	1	mean+SEM	mean+sem	UH
cord-015021-pol2qm74	3602	2	,	,	,
cord-015021-pol2qm74	3602	3	n=5	n=5	JJ
cord-015021-pol2qm74	3603	1	In	in	IN
cord-015021-pol2qm74	3603	2	several	several	JJ
cord-015021-pol2qm74	3603	3	experimental	experimental	JJ
cord-015021-pol2qm74	3603	4	models	model	NNS
cord-015021-pol2qm74	3603	5	of	of	IN
cord-015021-pol2qm74	3603	6	infection	infection	NN
cord-015021-pol2qm74	3603	7	exacerbation	exacerbation	NN
cord-015021-pol2qm74	3603	8	of	of	IN
cord-015021-pol2qm74	3603	9	disease	disease	NN
cord-015021-pol2qm74	3603	10	was	be	VBD
cord-015021-pol2qm74	3603	11	observed	observe	VBN
cord-015021-pol2qm74	3603	12	,	,	,
cord-015021-pol2qm74	3603	13	when	when	WRB
cord-015021-pol2qm74	3603	14	infected	infected	JJ
cord-015021-pol2qm74	3603	15	animals	animal	NNS
cord-015021-pol2qm74	3603	16	were	be	VBD
cord-015021-pol2qm74	3603	17	depleted	deplete	VBN
cord-015021-pol2qm74	3603	18	of	of	IN
cord-015021-pol2qm74	3603	19	tuaJor	tuajor	JJ
cord-015021-pol2qm74	3603	20	necrosis	necrosis	NN
cord-015021-pol2qm74	3603	21	factor	factor	NN
cord-015021-pol2qm74	3603	22	(	(	-LRB-
cord-015021-pol2qm74	3603	23	TNF	TNF	NNP
cord-015021-pol2qm74	3603	24	)	)	-RRB-
cord-015021-pol2qm74	3603	25	.	.	.
cord-015021-pol2qm74	3604	1	After	after	IN
cord-015021-pol2qm74	3604	2	sublethal	sublethal	JJ
cord-015021-pol2qm74	3604	3	cecal	cecal	JJ
cord-015021-pol2qm74	3604	4	ligation	ligation	NN
cord-015021-pol2qm74	3604	5	and	and	CC
cord-015021-pol2qm74	3604	6	puncture	puncture	NN
cord-015021-pol2qm74	3604	7	(	(	-LRB-
cord-015021-pol2qm74	3604	8	CLP	CLP	NNP
cord-015021-pol2qm74	3604	9	)	)	-RRB-
cord-015021-pol2qm74	3604	10	leading	lead	VBG
cord-015021-pol2qm74	3604	11	to	to	IN
cord-015021-pol2qm74	3604	12	peritonitis	peritonitis	NN
cord-015021-pol2qm74	3604	13	and	and	CC
cord-015021-pol2qm74	3604	14	sepsis	sepsis	VB
cord-015021-pol2qm74	3604	15	the	the	DT
cord-015021-pol2qm74	3604	16	survival	survival	NN
cord-015021-pol2qm74	3604	17	of	of	IN
cord-015021-pol2qm74	3604	18	mice	mouse	NNS
cord-015021-pol2qm74	3604	19	also	also	RB
cord-015021-pol2qm74	3604	20	critically	critically	RB
cord-015021-pol2qm74	3604	21	depends	depend	VBZ
cord-015021-pol2qm74	3604	22	on	on	IN
cord-015021-pol2qm74	3604	23	TNF	TNF	NNP
cord-015021-pol2qm74	3604	24	as	as	IN
cord-015021-pol2qm74	3604	25	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3604	26	in	in	IN
cord-015021-pol2qm74	3604	27	earlier	early	JJR
cord-015021-pol2qm74	3604	28	studies	study	NNS
cord-015021-pol2qm74	3604	29	,	,	,
cord-015021-pol2qm74	3604	30	when	when	WRB
cord-015021-pol2qm74	3604	31	CLP	CLP	NNP
cord-015021-pol2qm74	3604	32	-	-	HYPH
cord-015021-pol2qm74	3604	33	treated	treat	VBN
cord-015021-pol2qm74	3604	34	mice	mouse	NNS
cord-015021-pol2qm74	3604	35	injected	inject	VBN
cord-015021-pol2qm74	3604	36	with	with	IN
cord-015021-pol2qm74	3604	37	anti	anti	JJ
cord-015021-pol2qm74	3604	38	-	-	JJ
cord-015021-pol2qm74	3604	39	TNF	TNF	NNP
cord-015021-pol2qm74	3604	40	antibody	antibody	NN
cord-015021-pol2qm74	3604	41	died	die	VBD
cord-015021-pol2qm74	3604	42	,	,	,
cord-015021-pol2qm74	3604	43	whereas	whereas	IN
cord-015021-pol2qm74	3604	44	mice	mouse	NNS
cord-015021-pol2qm74	3604	45	injected	inject	VBD
cord-015021-pol2qm74	3604	46	with	with	IN
cord-015021-pol2qm74	3604	47	a	a	DT
cord-015021-pol2qm74	3604	48	control	control	NN
cord-015021-pol2qm74	3604	49	antibody	antibody	NN
cord-015021-pol2qm74	3604	50	survived	survive	VBD
cord-015021-pol2qm74	3604	51	after	after	IN
cord-015021-pol2qm74	3604	52	CLP	CLP	NNP
cord-015021-pol2qm74	3604	53	(	(	-LRB-
cord-015021-pol2qm74	3604	54	Echtenacher	Echtenacher	NNP
cord-015021-pol2qm74	3604	55	et	et	NNP
cord-015021-pol2qm74	3604	56	al	al	NNP
cord-015021-pol2qm74	3604	57	.	.	NNP
cord-015021-pol2qm74	3604	58	1990	1990	CD
cord-015021-pol2qm74	3604	59	,	,	,
cord-015021-pol2qm74	3604	60	J.	J.	NNP
cord-015021-pol2qm74	3604	61	Inununol	Inununol	NNP
cord-015021-pol2qm74	3604	62	.	.	.
cord-015021-pol2qm74	3605	1	145	145	CD
cord-015021-pol2qm74	3605	2	:	:	SYM
cord-015021-pol2qm74	3605	3	3762	3762	CD
cord-015021-pol2qm74	3605	4	)	)	-RRB-
cord-015021-pol2qm74	3605	5	.	.	.
cord-015021-pol2qm74	3606	1	From	from	IN
cord-015021-pol2qm74	3606	2	a	a	DT
cord-015021-pol2qm74	3606	3	panel	panel	NN
cord-015021-pol2qm74	3606	4	of	of	IN
cord-015021-pol2qm74	3606	5	different	different	JJ
cord-015021-pol2qm74	3606	6	cell	cell	NN
cord-015021-pol2qm74	3606	7	types	type	NNS
cord-015021-pol2qm74	3606	8	(	(	-LRB-
cord-015021-pol2qm74	3606	9	macrophages	macrophage	NNS
cord-015021-pol2qm74	3606	10	,	,	,
cord-015021-pol2qm74	3606	11	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	3606	12	,	,	,
cord-015021-pol2qm74	3606	13	T	t	NN
cord-015021-pol2qm74	3606	14	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	3606	15	,	,	,
cord-015021-pol2qm74	3606	16	natural	natural	JJ
cord-015021-pol2qm74	3606	17	killer	killer	NN
cord-015021-pol2qm74	3606	18	cells	cell	NNS
cord-015021-pol2qm74	3606	19	,	,	,
cord-015021-pol2qm74	3606	20	mast	mast	NN
cord-015021-pol2qm74	3606	21	cells	cell	NNS
cord-015021-pol2qm74	3606	22	)	)	-RRB-
cord-015021-pol2qm74	3606	23	able	able	JJ
cord-015021-pol2qm74	3606	24	to	to	TO
cord-015021-pol2qm74	3606	25	produce	produce	VB
cord-015021-pol2qm74	3606	26	TNF	TNF	NNP
cord-015021-pol2qm74	3606	27	upon	upon	IN
cord-015021-pol2qm74	3606	28	activation~	activation~	NN
cord-015021-pol2qm74	3607	1	the	the	DT
cord-015021-pol2qm74	3607	2	mast	mast	JJ
cord-015021-pol2qm74	3607	3	cell	cell	NN
cord-015021-pol2qm74	3607	4	is	be	VBZ
cord-015021-pol2qm74	3607	5	apparantly	apparantly	RB
cord-015021-pol2qm74	3607	6	the	the	DT
cord-015021-pol2qm74	3607	7	only	only	JJ
cord-015021-pol2qm74	3607	8	one	one	CD
cord-015021-pol2qm74	3607	9	capable	capable	JJ
cord-015021-pol2qm74	3607	10	of	of	IN
cord-015021-pol2qm74	3607	11	storing	store	VBG
cord-015021-pol2qm74	3607	12	in	in	IN
cord-015021-pol2qm74	3607	13	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	3607	14	granules	granule	NNS
cord-015021-pol2qm74	3607	15	preformed	preform	VBN
cord-015021-pol2qm74	3607	16	TNF	TNF	NNP
cord-015021-pol2qm74	3607	17	-	-	HYPH
cord-015021-pol2qm74	3607	18	ct	ct	NNP
cord-015021-pol2qm74	3607	19	which	which	WDT
cord-015021-pol2qm74	3607	20	is	be	VBZ
cord-015021-pol2qm74	3607	21	rapidly	rapidly	RB
cord-015021-pol2qm74	3607	22	released	release	VBN
cord-015021-pol2qm74	3607	23	following	follow	VBG
cord-015021-pol2qm74	3607	24	challenge	challenge	NN
cord-015021-pol2qm74	3607	25	.	.	.
cord-015021-pol2qm74	3608	1	In	in	IN
cord-015021-pol2qm74	3608	2	the	the	DT
cord-015021-pol2qm74	3608	3	present	present	JJ
cord-015021-pol2qm74	3608	4	study	study	NN
cord-015021-pol2qm74	3608	5	-	-	:
cord-015021-pol2qm74	3608	6	we	-PRON-	PRP
cord-015021-pol2qm74	3608	7	analyzed	analyze	VBD
cord-015021-pol2qm74	3608	8	serum	serum	NN
cord-015021-pol2qm74	3608	9	TNF	tnf	NN
cord-015021-pol2qm74	3608	10	after	after	IN
cord-015021-pol2qm74	3608	11	LPS	LPS	NNP
cord-015021-pol2qm74	3608	12	injections	injection	NNS
cord-015021-pol2qm74	3608	13	as	as	RB
cord-015021-pol2qm74	3608	14	well	well	RB
cord-015021-pol2qm74	3608	15	as	as	IN
cord-015021-pol2qm74	3608	16	the	the	DT
cord-015021-pol2qm74	3608	17	outcome	outcome	NN
cord-015021-pol2qm74	3608	18	of	of	IN
cord-015021-pol2qm74	3608	19	CLP	CLP	NNP
cord-015021-pol2qm74	3608	20	in	in	IN
cord-015021-pol2qm74	3608	21	severely	severely	RB
cord-015021-pol2qm74	3608	22	mast	mast	JJ
cord-015021-pol2qm74	3608	23	cell	cell	NN
cord-015021-pol2qm74	3608	24	deficient	deficient	JJ
cord-015021-pol2qm74	3608	25	mutant	mutant	JJ
cord-015021-pol2qm74	3608	26	mice	mouse	NNS
cord-015021-pol2qm74	3608	27	(	(	-LRB-
cord-015021-pol2qm74	3608	28	WAV	WAV	NNP
cord-015021-pol2qm74	3608	29	v	v	NNP
cord-015021-pol2qm74	3608	30	)	)	-RRB-
cord-015021-pol2qm74	3608	31	as	as	IN
cord-015021-pol2qm74	3608	32	compared	compare	VBN
cord-015021-pol2qm74	3608	33	to	to	TO
cord-015021-pol2qm74	3608	34	syngeaeic	syngeaeic	VB
cord-015021-pol2qm74	3608	35	wild	wild	JJ
cord-015021-pol2qm74	3608	36	-	-	HYPH
cord-015021-pol2qm74	3608	37	type	type	NN
cord-015021-pol2qm74	3608	38	littermates	littermate	NNS
cord-015021-pol2qm74	3608	39	(	(	-LRB-
cord-015021-pol2qm74	3608	40	+	+	CC
cord-015021-pol2qm74	3608	41	/+	/+	.
cord-015021-pol2qm74	3608	42	)	)	-RRB-
cord-015021-pol2qm74	3608	43	.	.	.
cord-015021-pol2qm74	3609	1	We	-PRON-	PRP
cord-015021-pol2qm74	3609	2	proposed	propose	VBD
cord-015021-pol2qm74	3609	3	that	that	IN
cord-015021-pol2qm74	3609	4	concentrations	concentration	NNS
cord-015021-pol2qm74	3609	5	and/or	and/or	CC
cord-015021-pol2qm74	3609	6	kinetics	kinetic	NNS
cord-015021-pol2qm74	3609	7	of	of	IN
cord-015021-pol2qm74	3609	8	serum	serum	NN
cord-015021-pol2qm74	3609	9	TNF	TNF	NNP
cord-015021-pol2qm74	3609	10	should	should	MD
cord-015021-pol2qm74	3609	11	be	be	VB
cord-015021-pol2qm74	3609	12	different	different	JJ
cord-015021-pol2qm74	3609	13	between	between	IN
cord-015021-pol2qm74	3609	14	WAVv	WAVv	NNS
cord-015021-pol2qm74	3609	15	mutants	mutant	NNS
cord-015021-pol2qm74	3609	16	and	and	CC
cord-015021-pol2qm74	3609	17	wild	wild	JJ
cord-015021-pol2qm74	3609	18	-	-	HYPH
cord-015021-pol2qm74	3609	19	type	type	NN
cord-015021-pol2qm74	3609	20	mice	mouse	NNS
cord-015021-pol2qm74	3609	21	,	,	,
cord-015021-pol2qm74	3609	22	if	if	IN
cord-015021-pol2qm74	3609	23	mast	mast	JJ
cord-015021-pol2qm74	3609	24	cell	cell	NN
cord-015021-pol2qm74	3609	25	-	-	HYPH
cord-015021-pol2qm74	3609	26	derived	derive	VBN
cord-015021-pol2qm74	3609	27	TNF	TNF	NNP
cord-015021-pol2qm74	3609	28	significantly	significantly	RB
cord-015021-pol2qm74	3609	29	contributes	contribute	VBZ
cord-015021-pol2qm74	3609	30	to	to	IN
cord-015021-pol2qm74	3609	31	the	the	DT
cord-015021-pol2qm74	3609	32	rise	rise	NN
cord-015021-pol2qm74	3609	33	in	in	IN
cord-015021-pol2qm74	3609	34	serum	serum	NN
cord-015021-pol2qm74	3609	35	TNF	tnf	NN
cord-015021-pol2qm74	3609	36	levels	level	NNS
cord-015021-pol2qm74	3609	37	following	follow	VBG
cord-015021-pol2qm74	3609	38	systemic	systemic	JJ
cord-015021-pol2qm74	3609	39	stimulation	stimulation	NN
cord-015021-pol2qm74	3609	40	with	with	IN
cord-015021-pol2qm74	3609	41	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3609	42	.	.	.
cord-015021-pol2qm74	3610	1	Although	although	IN
cord-015021-pol2qm74	3610	2	similar	similar	JJ
cord-015021-pol2qm74	3610	3	levels	level	NNS
cord-015021-pol2qm74	3610	4	of	of	IN
cord-015021-pol2qm74	3610	5	increased	increase	VBN
cord-015021-pol2qm74	3610	6	TNF	TNF	NNP
cord-015021-pol2qm74	3610	7	were	be	VBD
cord-015021-pol2qm74	3610	8	detected	detect	VBN
cord-015021-pol2qm74	3610	9	in	in	IN
cord-015021-pol2qm74	3610	10	the	the	DT
cord-015021-pol2qm74	3610	11	sera	sera	NNP
cord-015021-pol2qm74	3610	12	of	of	IN
cord-015021-pol2qm74	3610	13	both	both	DT
cord-015021-pol2qm74	3610	14	genotypes	genotype	NNS
cord-015021-pol2qm74	3610	15	after	after	IN
cord-015021-pol2qm74	3610	16	1	1	CD
cord-015021-pol2qm74	3610	17	and	and	CC
cord-015021-pol2qm74	3610	18	2	2	CD
cord-015021-pol2qm74	3610	19	hours	hour	NNS
cord-015021-pol2qm74	3610	20	of	of	IN
cord-015021-pol2qm74	3610	21	LPS	LPS	NNP
cord-015021-pol2qm74	3610	22	injection	injection	NN
cord-015021-pol2qm74	3610	23	(	(	-LRB-
cord-015021-pol2qm74	3610	24	100	100	CD
cord-015021-pol2qm74	3610	25	btg/	btg/	NNP
cord-015021-pol2qm74	3610	26	0.5	0.5	CD
cord-015021-pol2qm74	3610	27	ml	ml	NN
cord-015021-pol2qm74	3610	28	/	/	SYM
cord-015021-pol2qm74	3610	29	mouse	mouse	NN
cord-015021-pol2qm74	3610	30	i.	i.	NNP
cord-015021-pol2qm74	3610	31	p.	p.	NN
cord-015021-pol2qm74	3610	32	)	)	-RRB-
cord-015021-pol2qm74	3610	33	,	,	,
cord-015021-pol2qm74	3610	34	mast	mast	NN
cord-015021-pol2qm74	3610	35	ceil	ceil	NN
cord-015021-pol2qm74	3610	36	-	-	HYPH
cord-015021-pol2qm74	3610	37	deficient	deficient	JJ
cord-015021-pol2qm74	3610	38	mice	mouse	NNS
cord-015021-pol2qm74	3610	39	indeed	indeed	RB
cord-015021-pol2qm74	3610	40	showed	show	VBD
cord-015021-pol2qm74	3610	41	decreased	decrease	VBD
cord-015021-pol2qm74	3610	42	serum	serum	NN
cord-015021-pol2qm74	3610	43	TNF	TNF	NNP
cord-015021-pol2qm74	3610	44	levels	level	NNS
cord-015021-pol2qm74	3610	45	30	30	CD
cord-015021-pol2qm74	3610	46	iron	iron	NN
cord-015021-pol2qm74	3610	47	after	after	IN
cord-015021-pol2qm74	3610	48	injection	injection	NN
cord-015021-pol2qm74	3610	49	amounting	amount	VBG
cord-015021-pol2qm74	3610	50	to	to	IN
cord-015021-pol2qm74	3610	51	only	only	RB
cord-015021-pol2qm74	3610	52	12	12	CD
cord-015021-pol2qm74	3610	53	to	to	TO
cord-015021-pol2qm74	3610	54	25	25	CD
cord-015021-pol2qm74	3610	55	%	%	NN
cord-015021-pol2qm74	3610	56	of	of	IN
cord-015021-pol2qm74	3610	57	the	the	DT
cord-015021-pol2qm74	3610	58	concentrations	concentration	NNS
cord-015021-pol2qm74	3610	59	observed	observe	VBN
cord-015021-pol2qm74	3610	60	in	in	IN
cord-015021-pol2qm74	3610	61	the	the	DT
cord-015021-pol2qm74	3610	62	corresponding	correspond	VBG
cord-015021-pol2qm74	3610	63	sera	sera	NNP
cord-015021-pol2qm74	3610	64	of	of	IN
cord-015021-pol2qm74	3610	65	normal	normal	JJ
cord-015021-pol2qm74	3610	66	wildtype	wildtype	NN
cord-015021-pol2qm74	3610	67	mice	mouse	NNS
cord-015021-pol2qm74	3610	68	.	.	.
cord-015021-pol2qm74	3611	1	In	in	IN
cord-015021-pol2qm74	3611	2	the	the	DT
cord-015021-pol2qm74	3611	3	CLP	CLP	NNP
cord-015021-pol2qm74	3611	4	model	model	NN
cord-015021-pol2qm74	3611	5	of	of	IN
cord-015021-pol2qm74	3611	6	septic	septic	JJ
cord-015021-pol2qm74	3611	7	peritonitis	peritonitis	NN
cord-015021-pol2qm74	3611	8	we	-PRON-	PRP
cord-015021-pol2qm74	3611	9	found	find	VBD
cord-015021-pol2qm74	3611	10	that	that	IN
cord-015021-pol2qm74	3611	11	mast	mast	NN
cord-015021-pol2qm74	3611	12	celldeficient	celldeficient	JJ
cord-015021-pol2qm74	3611	13	mutant	mutant	JJ
cord-015021-pol2qm74	3611	14	mice	mouse	NNS
cord-015021-pol2qm74	3611	15	were	be	VBD
cord-015021-pol2qm74	3611	16	dramatically	dramatically	RB
cord-015021-pol2qm74	3611	17	more	more	RBR
cord-015021-pol2qm74	3611	18	sensitive	sensitive	JJ
cord-015021-pol2qm74	3611	19	to	to	IN
cord-015021-pol2qm74	3611	20	CLP	CLP	NNP
cord-015021-pol2qm74	3611	21	than	than	IN
cord-015021-pol2qm74	3611	22	syngeneic	syngeneic	NNS
cord-015021-pol2qm74	3611	23	normal	normal	JJ
cord-015021-pol2qm74	3611	24	mice	mouse	NNS
cord-015021-pol2qm74	3611	25	resulting	result	VBG
cord-015021-pol2qm74	3611	26	in	in	IN
cord-015021-pol2qm74	3611	27	92	92	CD
cord-015021-pol2qm74	3611	28	%	%	NN
cord-015021-pol2qm74	3611	29	mortality	mortality	NN
cord-015021-pol2qm74	3611	30	in	in	IN
cord-015021-pol2qm74	3611	31	W	W	NNP
cord-015021-pol2qm74	3611	32	/	/	SYM
cord-015021-pol2qm74	3611	33	W	w	NN
cord-015021-pol2qm74	3611	34	v	v	NN
cord-015021-pol2qm74	3611	35	versus	versus	IN
cord-015021-pol2qm74	3611	36	8	8	CD
cord-015021-pol2qm74	3611	37	%	%	NN
cord-015021-pol2qm74	3611	38	mortality	mortality	NN
cord-015021-pol2qm74	3611	39	in	in	IN
cord-015021-pol2qm74	3612	1	+	+	CC
cord-015021-pol2qm74	3612	2	/+	/+	,
cord-015021-pol2qm74	3612	3	mice	mouse	NNS
cord-015021-pol2qm74	3612	4	2.5	2.5	CD
cord-015021-pol2qm74	3612	5	days	day	NNS
cord-015021-pol2qm74	3612	6	after	after	IN
cord-015021-pol2qm74	3612	7	initiation	initiation	NN
cord-015021-pol2qm74	3612	8	of	of	IN
cord-015021-pol2qm74	3612	9	CLP	CLP	NNP
cord-015021-pol2qm74	3612	10	.	.	.
cord-015021-pol2qm74	3613	1	Further	further	JJ
cord-015021-pol2qm74	3613	2	experiments	experiment	NNS
cord-015021-pol2qm74	3613	3	with	with	IN
cord-015021-pol2qm74	3613	4	W	W	NNP
cord-015021-pol2qm74	3613	5	/	/	SYM
cord-015021-pol2qm74	3613	6	W	w	NN
cord-015021-pol2qm74	3613	7	v	v	IN
cord-015021-pol2qm74	3613	8	mutants	mutant	NNS
cord-015021-pol2qm74	3613	9	selectively	selectively	RB
cord-015021-pol2qm74	3613	10	reconstituted	reconstitute	VBN
cord-015021-pol2qm74	3613	11	with	with	IN
cord-015021-pol2qm74	3613	12	cultured	cultured	JJ
cord-015021-pol2qm74	3613	13	bone	bone	NN
cord-015021-pol2qm74	3613	14	marrow	marrow	NN
cord-015021-pol2qm74	3613	15	-	-	HYPH
cord-015021-pol2qm74	3613	16	derived	derive	VBN
cord-015021-pol2qm74	3613	17	mast	mast	NN
cord-015021-pol2qm74	3613	18	cells	cell	NNS
cord-015021-pol2qm74	3613	19	from	from	IN
cord-015021-pol2qm74	3613	20	normal	normal	JJ
cord-015021-pol2qm74	3613	21	syngeneic	syngeneic	NNS
cord-015021-pol2qm74	3613	22	wild	wild	JJ
cord-015021-pol2qm74	3613	23	-	-	HYPH
cord-015021-pol2qm74	3613	24	type	type	NN
cord-015021-pol2qm74	3613	25	mice	mouse	NNS
cord-015021-pol2qm74	3613	26	and	and	CC
cord-015021-pol2qm74	3613	27	the	the	DT
cord-015021-pol2qm74	3613	28	use	use	NN
cord-015021-pol2qm74	3613	29	of	of	IN
cord-015021-pol2qm74	3613	30	an	an	DT
cord-015021-pol2qm74	3613	31	antibody	antibody	NN
cord-015021-pol2qm74	3613	32	specifically	specifically	RB
cord-015021-pol2qm74	3613	33	blocking	block	VBG
cord-015021-pol2qm74	3613	34	the	the	DT
cord-015021-pol2qm74	3613	35	action	action	NN
cord-015021-pol2qm74	3613	36	of	of	IN
cord-015021-pol2qm74	3613	37	TNF	TNF	NNP
cord-015021-pol2qm74	3613	38	tn	tn	NNP
cord-015021-pol2qm74	3613	39	vivo	vivo	NN
cord-015021-pol2qm74	3613	40	should	should	MD
cord-015021-pol2qm74	3613	41	clarify	clarify	VB
cord-015021-pol2qm74	3613	42	a	a	DT
cord-015021-pol2qm74	3613	43	potential	potential	JJ
cord-015021-pol2qm74	3613	44	protective	protective	JJ
cord-015021-pol2qm74	3613	45	function	function	NN
cord-015021-pol2qm74	3613	46	of	of	IN
cord-015021-pol2qm74	3613	47	mast	mast	NN
cord-015021-pol2qm74	3613	48	cells	cell	NNS
cord-015021-pol2qm74	3613	49	in	in	IN
cord-015021-pol2qm74	3613	50	this	this	DT
cord-015021-pol2qm74	3613	51	model	model	NN
cord-015021-pol2qm74	3613	52	of	of	IN
cord-015021-pol2qm74	3613	53	septic	septic	JJ
cord-015021-pol2qm74	3613	54	peritonitis	peritonitis	NN
cord-015021-pol2qm74	3613	55	.	.	.
cord-015021-pol2qm74	3614	1	Interleukin-10	Interleukin-10	NNP
cord-015021-pol2qm74	3614	2	(	(	-LRB-
cord-015021-pol2qm74	3614	3	IL-10	IL-10	NNP
cord-015021-pol2qm74	3614	4	)	)	-RRB-
cord-015021-pol2qm74	3614	5	inhibits	inhibit	VBZ
cord-015021-pol2qm74	3614	6	cytokine	cytokine	JJ
cord-015021-pol2qm74	3614	7	production	production	NN
cord-015021-pol2qm74	3614	8	,	,	,
cord-015021-pol2qm74	3614	9	including	include	VBG
cord-015021-pol2qm74	3614	10	tumor	tumor	NN
cord-015021-pol2qm74	3614	11	necrosis	necrosis	NN
cord-015021-pol2qm74	3614	12	factor	factor	NN
cord-015021-pol2qm74	3614	13	(	(	-LRB-
cord-015021-pol2qm74	3614	14	TNF	TNF	NNP
cord-015021-pol2qm74	3614	15	)	)	-RRB-
cord-015021-pol2qm74	3614	16	,	,	,
cord-015021-pol2qm74	3614	17	by	by	IN
cord-015021-pol2qm74	3614	18	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3614	19	(	(	-LRB-
cord-015021-pol2qm74	3614	20	LPS)-aetivated	lps)-aetivate	VBN
cord-015021-pol2qm74	3614	21	maerophages	maerophage	NNS
cord-015021-pol2qm74	3614	22	.	.	.
cord-015021-pol2qm74	3615	1	We	-PRON-	PRP
cord-015021-pol2qm74	3615	2	recently	recently	RB
cord-015021-pol2qm74	3615	3	observed	observe	VBD
cord-015021-pol2qm74	3615	4	that	that	IN
cord-015021-pol2qm74	3615	5	LPS	LPS	NNP
cord-015021-pol2qm74	3615	6	injection	injection	NN
cord-015021-pol2qm74	3615	7	(	(	-LRB-
cord-015021-pol2qm74	3615	8	E.coli	E.coli	NNS
cord-015021-pol2qm74	3615	9	055	055	CD
cord-015021-pol2qm74	3615	10	:	:	:
cord-015021-pol2qm74	3615	11	B5	B5	NNP
cord-015021-pol2qm74	3615	12	,	,	,
cord-015021-pol2qm74	3615	13	100	100	CD
cord-015021-pol2qm74	3615	14	gg	gg	NNP
cord-015021-pol2qm74	3615	15	ip	ip	NN
cord-015021-pol2qm74	3615	16	)	)	-RRB-
cord-015021-pol2qm74	3615	17	into	into	IN
cord-015021-pol2qm74	3615	18	Balb	Balb	NNP
cord-015021-pol2qm74	3615	19	/	/	SYM
cord-015021-pol2qm74	3615	20	c	c	NN
cord-015021-pol2qm74	3615	21	mice	mice	NN
cord-015021-pol2qm74	3615	22	induces	induce	VBZ
cord-015021-pol2qm74	3615	23	the	the	DT
cord-015021-pol2qm74	3615	24	rapid	rapid	JJ
cord-015021-pol2qm74	3615	25	release	release	NN
cord-015021-pol2qm74	3615	26	of	of	IN
cord-015021-pol2qm74	3615	27	circulating	circulate	VBG
cord-015021-pol2qm74	3615	28	IL-10	IL-10	NNP
cord-015021-pol2qm74	3615	29	(	(	-LRB-
cord-015021-pol2qm74	3615	30	17±9	17±9	CD
cord-015021-pol2qm74	3615	31	U	U	NNP
cord-015021-pol2qm74	3615	32	/	/	SYM
cord-015021-pol2qm74	3615	33	ml	ml	XX
cord-015021-pol2qm74	3615	34	at	at	IN
cord-015021-pol2qm74	3615	35	90	90	CD
cord-015021-pol2qm74	3615	36	min	min	NN
cord-015021-pol2qm74	3615	37	)	)	-RRB-
cord-015021-pol2qm74	3615	38	.	.	.
cord-015021-pol2qm74	3616	1	Blocking	block	VBG
cord-015021-pol2qm74	3616	2	endogenous	endogenous	JJ
cord-015021-pol2qm74	3616	3	IL-10	IL-10	NNP
cord-015021-pol2qm74	3616	4	using	use	VBG
cord-015021-pol2qm74	3616	5	monocIonal	monocional	JJ
cord-015021-pol2qm74	3616	6	antibody	antibody	NN
cord-015021-pol2qm74	3616	7	(	(	-LRB-
cord-015021-pol2qm74	3616	8	JES5	JES5	NNP
cord-015021-pol2qm74	3616	9	-	-	HYPH
cord-015021-pol2qm74	3616	10	2A5	2a5	CD
cord-015021-pol2qm74	3616	11	,	,	,
cord-015021-pol2qm74	3616	12	2	2	CD
cord-015021-pol2qm74	3616	13	mg	mg	NNP
cord-015021-pol2qm74	3616	14	,	,	,
cord-015021-pol2qm74	3616	15	2h	2h	CD
cord-015021-pol2qm74	3616	16	before	before	IN
cord-015021-pol2qm74	3616	17	LPS	LPS	NNP
cord-015021-pol2qm74	3616	18	)	)	-RRB-
cord-015021-pol2qm74	3616	19	resulted	result	VBD
cord-015021-pol2qm74	3616	20	in	in	IN
cord-015021-pol2qm74	3616	21	a	a	DT
cord-015021-pol2qm74	3616	22	massive	massive	JJ
cord-015021-pol2qm74	3616	23	increase	increase	NN
cord-015021-pol2qm74	3616	24	in	in	IN
cord-015021-pol2qm74	3616	25	TNF	TNF	NNP
cord-015021-pol2qm74	3616	26	production	production	NN
cord-015021-pol2qm74	3616	27	(	(	-LRB-
cord-015021-pol2qm74	3616	28	107±47	107±47	CD
cord-015021-pol2qm74	3616	29	in	in	IN
cord-015021-pol2qm74	3617	1	LPS+anti	LPS+anti	NNP
cord-015021-pol2qm74	3617	2	-	-	HYPH
cord-015021-pol2qm74	3617	3	IL-10	IL-10	NNP
cord-015021-pol2qm74	3617	4	treated	treat	VBD
cord-015021-pol2qm74	3617	5	mice	mouse	NNS
cord-015021-pol2qm74	3617	6	vs	vs	IN
cord-015021-pol2qm74	3617	7	6±2	6±2	CD
cord-015021-pol2qm74	3617	8	ng	ng	NN
cord-015021-pol2qm74	3617	9	/	/	SYM
cord-015021-pol2qm74	3617	10	ml	ml	NN
cord-015021-pol2qm74	3617	11	in	in	IN
cord-015021-pol2qm74	3617	12	LPS	LPS	NNP
cord-015021-pol2qm74	3617	13	alone	alone	RB
cord-015021-pol2qm74	3617	14	,	,	,
cord-015021-pol2qm74	3617	15	p<0.05	p<0.05	CD
cord-015021-pol2qm74	3617	16	,	,	,
cord-015021-pol2qm74	3617	17	n=4	n=4	JJ
cord-015021-pol2qm74	3617	18	to	to	IN
cord-015021-pol2qm74	3617	19	5	5	CD
cord-015021-pol2qm74	3617	20	mice	mouse	NNS
cord-015021-pol2qm74	3617	21	per	per	IN
cord-015021-pol2qm74	3617	22	group	group	NN
cord-015021-pol2qm74	3617	23	)	)	-RRB-
cord-015021-pol2qm74	3617	24	and	and	CC
cord-015021-pol2qm74	3617	25	an	an	DT
cord-015021-pol2qm74	3617	26	enhanced	enhanced	JJ
cord-015021-pol2qm74	3617	27	LPS	LPS	NNP
cord-015021-pol2qm74	3617	28	-	-	HYPH
cord-015021-pol2qm74	3617	29	induccd	induccd	NN
cord-015021-pol2qm74	3617	30	lethality	lethality	NN
cord-015021-pol2qm74	3617	31	(	(	-LRB-
cord-015021-pol2qm74	3617	32	53	53	CD
cord-015021-pol2qm74	3617	33	%	%	NN
cord-015021-pol2qm74	3617	34	vs	vs	IN
cord-015021-pol2qm74	3617	35	7	7	CD
cord-015021-pol2qm74	3617	36	%	%	NN
cord-015021-pol2qm74	3617	37	in	in	IN
cord-015021-pol2qm74	3617	38	anti	anti	JJ
cord-015021-pol2qm74	3617	39	-	-	JJ
cord-015021-pol2qm74	3617	40	IL-10+LPS	il-10+lps	JJ
cord-015021-pol2qm74	3617	41	or	or	CC
cord-015021-pol2qm74	3617	42	LPS	LPS	NNP
cord-015021-pol2qm74	3617	43	alone	alone	RB
cord-015021-pol2qm74	3617	44	respectively	respectively	RB
cord-015021-pol2qm74	3617	45	,	,	,
cord-015021-pol2qm74	3617	46	p=0.01	p=0.01	NNP
cord-015021-pol2qm74	3617	47	,	,	,
cord-015021-pol2qm74	3617	48	n=15	n=15	JJ
cord-015021-pol2qm74	3617	49	mice	mouse	NNS
cord-015021-pol2qm74	3617	50	per	per	IN
cord-015021-pol2qm74	3617	51	group	group	NN
cord-015021-pol2qm74	3617	52	)	)	-RRB-
cord-015021-pol2qm74	3617	53	.	.	.
cord-015021-pol2qm74	3618	1	Irrelevant	irrelevant	JJ
cord-015021-pol2qm74	3618	2	IgG1	IgG1	NNP
cord-015021-pol2qm74	3618	3	rat	rat	NN
cord-015021-pol2qm74	3618	4	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	3618	5	antibody	antibody	NN
cord-015021-pol2qm74	3618	6	(	(	-LRB-
cord-015021-pol2qm74	3618	7	LO	LO	NNP
cord-015021-pol2qm74	3618	8	-	-	HYPH
cord-015021-pol2qm74	3618	9	DNP	DNP	NNP
cord-015021-pol2qm74	3618	10	)	)	-RRB-
cord-015021-pol2qm74	3618	11	did	do	VBD
cord-015021-pol2qm74	3618	12	not	not	RB
cord-015021-pol2qm74	3618	13	influence	influence	VB
cord-015021-pol2qm74	3618	14	neither	neither	CC
cord-015021-pol2qm74	3618	15	TNF	TNF	NNP
cord-015021-pol2qm74	3618	16	production	production	NN
cord-015021-pol2qm74	3618	17	nor	nor	CC
cord-015021-pol2qm74	3618	18	lethality	lethality	NN
cord-015021-pol2qm74	3618	19	associated	associate	VBN
cord-015021-pol2qm74	3618	20	with	with	IN
cord-015021-pol2qm74	3618	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3618	22	shock	shock	NN
cord-015021-pol2qm74	3618	23	.	.	.
cord-015021-pol2qm74	3619	1	This	this	DT
cord-015021-pol2qm74	3619	2	led	lead	VBD
cord-015021-pol2qm74	3619	3	us	-PRON-	PRP
cord-015021-pol2qm74	3619	4	to	to	TO
cord-015021-pol2qm74	3619	5	study	study	VB
cord-015021-pol2qm74	3619	6	the	the	DT
cord-015021-pol2qm74	3619	7	production	production	NN
cord-015021-pol2qm74	3619	8	of	of	IN
cord-015021-pol2qm74	3619	9	IL-10	IL-10	NNP
cord-015021-pol2qm74	3619	10	during	during	IN
cord-015021-pol2qm74	3619	11	human	human	JJ
cord-015021-pol2qm74	3619	12	septicemia	septicemia	NN
cord-015021-pol2qm74	3619	13	.	.	.
cord-015021-pol2qm74	3620	1	Plasma	plasma	NN
cord-015021-pol2qm74	3620	2	samples	sample	NNS
cord-015021-pol2qm74	3620	3	were	be	VBD
cord-015021-pol2qm74	3620	4	obtained	obtain	VBN
cord-015021-pol2qm74	3620	5	from	from	IN
cord-015021-pol2qm74	3620	6	65	65	CD
cord-015021-pol2qm74	3620	7	patients	patient	NNS
cord-015021-pol2qm74	3620	8	with	with	IN
cord-015021-pol2qm74	3620	9	gramnegative	gramnegative	NN
cord-015021-pol2qm74	3620	10	(	(	-LRB-
cord-015021-pol2qm74	3620	11	GNS	GNS	NNP
cord-015021-pol2qm74	3620	12	,	,	,
cord-015021-pol2qm74	3620	13	n=22	n=22	NNP
cord-015021-pol2qm74	3620	14	)	)	-RRB-
cord-015021-pol2qm74	3620	15	or	or	CC
cord-015021-pol2qm74	3620	16	gram	gram	NN
cord-015021-pol2qm74	3620	17	-	-	HYPH
cord-015021-pol2qm74	3620	18	positive	positive	JJ
cord-015021-pol2qm74	3620	19	septicemia	septicemia	NN
cord-015021-pol2qm74	3620	20	(	(	-LRB-
cord-015021-pol2qm74	3620	21	GPS	GPS	NNP
cord-015021-pol2qm74	3620	22	,	,	,
cord-015021-pol2qm74	3620	23	n=43	n=43	NN
cord-015021-pol2qm74	3620	24	)	)	-RRB-
cord-015021-pol2qm74	3620	25	and	and	CC
cord-015021-pol2qm74	3620	26	from	from	IN
cord-015021-pol2qm74	3620	27	20	20	CD
cord-015021-pol2qm74	3620	28	healthy	healthy	JJ
cord-015021-pol2qm74	3620	29	volunteers	volunteer	NNS
cord-015021-pol2qm74	3620	30	.	.	.
cord-015021-pol2qm74	3621	1	Among	among	IN
cord-015021-pol2qm74	3621	2	these	these	DT
cord-015021-pol2qm74	3621	3	patients	patient	NNS
cord-015021-pol2qm74	3621	4	,	,	,
cord-015021-pol2qm74	3621	5	17	17	CD
cord-015021-pol2qm74	3621	6	suffered	suffer	VBD
cord-015021-pol2qm74	3621	7	from	from	IN
cord-015021-pol2qm74	3621	8	septic	septic	JJ
cord-015021-pol2qm74	3621	9	shock	shock	NN
cord-015021-pol2qm74	3621	10	at	at	IN
cord-015021-pol2qm74	3621	11	the	the	DT
cord-015021-pol2qm74	3621	12	time	time	NN
cord-015021-pol2qm74	3621	13	of	of	IN
cord-015021-pol2qm74	3621	14	sampling	sampling	NN
cord-015021-pol2qm74	3621	15	.	.	.
cord-015021-pol2qm74	3622	1	IL-10	IL-10	NNP
cord-015021-pol2qm74	3622	2	levels	level	NNS
cord-015021-pol2qm74	3622	3	were	be	VBD
cord-015021-pol2qm74	3622	4	measured	measure	VBN
cord-015021-pol2qm74	3622	5	by	by	IN
cord-015021-pol2qm74	3622	6	ELISA	ELISA	NNP
cord-015021-pol2qm74	3622	7	(	(	-LRB-
cord-015021-pol2qm74	3622	8	detection	detection	NN
cord-015021-pol2qm74	3622	9	limit	limit	NN
cord-015021-pol2qm74	3622	10	:	:	:
cord-015021-pol2qm74	3622	11	I	i	NN
cord-015021-pol2qm74	3622	12	1	1	CD
cord-015021-pol2qm74	3622	13	pghrd	pghrd	NNP
cord-015021-pol2qm74	3622	14	)	)	-RRB-
cord-015021-pol2qm74	3622	15	.	.	.
cord-015021-pol2qm74	3623	1	We	-PRON-	PRP
cord-015021-pol2qm74	3623	2	found	find	VBD
cord-015021-pol2qm74	3623	3	that	that	IN
cord-015021-pol2qm74	3623	4	35	35	CD
cord-015021-pol2qm74	3623	5	patients	patient	NNS
cord-015021-pol2qm74	3623	6	(	(	-LRB-
cord-015021-pol2qm74	3623	7	54	54	CD
cord-015021-pol2qm74	3623	8	%	%	NN
cord-015021-pol2qm74	3623	9	)	)	-RRB-
cord-015021-pol2qm74	3623	10	had	have	VBD
cord-015021-pol2qm74	3623	11	increased	increase	VBN
cord-015021-pol2qm74	3623	12	IL-10	IL-10	NNP
cord-015021-pol2qm74	3623	13	plasma	plasma	NN
cord-015021-pol2qm74	3623	14	levels	level	NNS
cord-015021-pol2qm74	3623	15	(	(	-LRB-
cord-015021-pol2qm74	3623	16	range	range	VBP
cord-015021-pol2qm74	3623	17	12	12	CD
cord-015021-pol2qm74	3623	18	to	to	IN
cord-015021-pol2qm74	3623	19	2740	2740	CD
cord-015021-pol2qm74	3623	20	pg	pg	NNP
cord-015021-pol2qm74	3623	21	/	/	SYM
cord-015021-pol2qm74	3623	22	nd	nd	NNP
cord-015021-pol2qm74	3623	23	)	)	-RRB-
cord-015021-pol2qm74	3623	24	.	.	.
cord-015021-pol2qm74	3624	1	Patients	patient	NNS
cord-015021-pol2qm74	3624	2	with	with	IN
cord-015021-pol2qm74	3624	3	GPS	GPS	NNP
cord-015021-pol2qm74	3624	4	had	have	VBD
cord-015021-pol2qm74	3624	5	IL-10	IL-10	NNP
cord-015021-pol2qm74	3624	6	levels	level	NNS
cord-015021-pol2qm74	3624	7	similar	similar	JJ
cord-015021-pol2qm74	3624	8	to	to	IN
cord-015021-pol2qm74	3624	9	the	the	DT
cord-015021-pol2qm74	3624	10	ones	one	NNS
cord-015021-pol2qm74	3624	11	observed	observe	VBN
cord-015021-pol2qm74	3624	12	in	in	IN
cord-015021-pol2qm74	3624	13	GNS	GNS	NNP
cord-015021-pol2qm74	3624	14	(	(	-LRB-
cord-015021-pol2qm74	3624	15	median	median	NN
cord-015021-pol2qm74	3624	16	:	:	:
cord-015021-pol2qm74	3624	17	12	12	CD
cord-015021-pol2qm74	3624	18	vs	vs	IN
cord-015021-pol2qm74	3624	19	17.5	17.5	CD
cord-015021-pol2qm74	3624	20	pg	pg	NNP
cord-015021-pol2qm74	3624	21	/	/	SYM
cord-015021-pol2qm74	3624	22	M	M	NNP
cord-015021-pol2qm74	3624	23	,	,	,
cord-015021-pol2qm74	3624	24	respectively	respectively	RB
cord-015021-pol2qm74	3624	25	)	)	-RRB-
cord-015021-pol2qm74	3624	26	.	.	.
cord-015021-pol2qm74	3625	1	Patients	patient	NNS
cord-015021-pol2qm74	3625	2	with	with	IN
cord-015021-pol2qm74	3625	3	septic	septic	JJ
cord-015021-pol2qm74	3625	4	shock	shock	NN
cord-015021-pol2qm74	3625	5	had	have	VBD
cord-015021-pol2qm74	3625	6	higher	high	JJR
cord-015021-pol2qm74	3625	7	IL-10	IL-10	NNP
cord-015021-pol2qm74	3625	8	values	value	NNS
cord-015021-pol2qm74	3625	9	(	(	-LRB-
cord-015021-pol2qm74	3625	10	median	median	NN
cord-015021-pol2qm74	3625	11	:	:	:
cord-015021-pol2qm74	3625	12	58	58	CD
cord-015021-pol2qm74	3625	13	pg	pg	NN
cord-015021-pol2qm74	3625	14	/	/	SYM
cord-015021-pol2qm74	3625	15	ml	ml	NNP
cord-015021-pol2qm74	3625	16	)	)	-RRB-
cord-015021-pol2qm74	3625	17	than	than	IN
cord-015021-pol2qm74	3625	18	septicemic	septicemic	JJ
cord-015021-pol2qm74	3625	19	patients	patient	NNS
cord-015021-pol2qm74	3625	20	without	without	IN
cord-015021-pol2qm74	3625	21	shock	shock	NN
cord-015021-pol2qm74	3625	22	(	(	-LRB-
cord-015021-pol2qm74	3625	23	11	11	CD
cord-015021-pol2qm74	3625	24	pg	pg	NNP
cord-015021-pol2qm74	3625	25	/	/	SYM
cord-015021-pol2qm74	3625	26	ml	ml	NNS
cord-015021-pol2qm74	3625	27	,	,	,
cord-015021-pol2qm74	3625	28	p=0.002	p=0.002	NNP
cord-015021-pol2qm74	3625	29	)	)	-RRB-
cord-015021-pol2qm74	3625	30	.	.	.
cord-015021-pol2qm74	3626	1	No	no	UH
cord-015021-pol2qm74	3626	2	IL-10	IL-10	NNP
cord-015021-pol2qm74	3626	3	was	be	VBD
cord-015021-pol2qm74	3626	4	detected	detect	VBN
cord-015021-pol2qm74	3626	5	in	in	IN
cord-015021-pol2qm74	3626	6	plasma	plasma	NN
cord-015021-pol2qm74	3626	7	from	from	IN
cord-015021-pol2qm74	3626	8	healthy	healthy	JJ
cord-015021-pol2qm74	3626	9	volunteers	volunteer	NNS
cord-015021-pol2qm74	3626	10	.	.	.
cord-015021-pol2qm74	3627	1	We	-PRON-	PRP
cord-015021-pol2qm74	3627	2	conclude	conclude	VBP
cord-015021-pol2qm74	3627	3	that	that	IN
cord-015021-pol2qm74	3627	4	IL-10	IL-10	NNP
cord-015021-pol2qm74	3627	5	is	be	VBZ
cord-015021-pol2qm74	3627	6	produced	produce	VBN
cord-015021-pol2qm74	3627	7	daring	daring	JJ
cord-015021-pol2qm74	3627	8	human	human	JJ
cord-015021-pol2qm74	3627	9	septicemia	septicemia	NN
cord-015021-pol2qm74	3627	10	.	.	.
cord-015021-pol2qm74	3628	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3628	2	experimental	experimental	JJ
cord-015021-pol2qm74	3628	3	data	datum	NNS
cord-015021-pol2qm74	3628	4	suggest	suggest	VBP
cord-015021-pol2qm74	3628	5	that	that	IN
cord-015021-pol2qm74	3628	6	IL-10	IL-10	NNP
cord-015021-pol2qm74	3628	7	might	may	MD
cord-015021-pol2qm74	3628	8	be	be	VB
cord-015021-pol2qm74	3628	9	involved	involve	VBN
cord-015021-pol2qm74	3628	10	in	in	IN
cord-015021-pol2qm74	3628	11	the	the	DT
cord-015021-pol2qm74	3628	12	control	control	NN
cord-015021-pol2qm74	3628	13	of	of	IN
cord-015021-pol2qm74	3628	14	the	the	DT
cord-015021-pol2qm74	3628	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3628	16	response	response	NN
cord-015021-pol2qm74	3628	17	induced	induce	VBN
cord-015021-pol2qm74	3628	18	by	by	IN
cord-015021-pol2qm74	3628	19	bacterial	bacterial	JJ
cord-015021-pol2qm74	3628	20	products	product	NNS
cord-015021-pol2qm74	3628	21	.	.	.
cord-015021-pol2qm74	3629	1	Dr	Dr	NNP
cord-015021-pol2qm74	3629	2	Arnand	Arnand	NNP
cord-015021-pol2qm74	3629	3	Marchant	Marchant	NNP
cord-015021-pol2qm74	3629	4	,	,	,
cord-015021-pol2qm74	3629	5	Immunology	Immunology	NNP
cord-015021-pol2qm74	3629	6	Department	Department	NNP
cord-015021-pol2qm74	3629	7	,	,	,
cord-015021-pol2qm74	3629	8	Hopital	Hopital	NNP
cord-015021-pol2qm74	3629	9	Erasme	Erasme	NNP
cord-015021-pol2qm74	3629	10	,	,	,
cord-015021-pol2qm74	3629	11	808	808	CD
cord-015021-pol2qm74	3629	12	Route	Route	NNP
cord-015021-pol2qm74	3629	13	de	de	NNP
cord-015021-pol2qm74	3629	14	Lennik	Lennik	NNP
cord-015021-pol2qm74	3629	15	,	,	,
cord-015021-pol2qm74	3629	16	1070	1070	CD
cord-015021-pol2qm74	3629	17	Brussels	Brussels	NNP
cord-015021-pol2qm74	3629	18	,	,	,
cord-015021-pol2qm74	3629	19	Belgium	Belgium	NNP
cord-015021-pol2qm74	3629	20	.	.	.
cord-015021-pol2qm74	3629	21	 	 	_SP
cord-015021-pol2qm74	3630	1	To	to	TO
cord-015021-pol2qm74	3630	2	provide	provide	VB
cord-015021-pol2qm74	3630	3	information	information	NN
cord-015021-pol2qm74	3630	4	about	about	IN
cord-015021-pol2qm74	3630	5	the	the	DT
cord-015021-pol2qm74	3630	6	role	role	NN
cord-015021-pol2qm74	3630	7	of	of	IN
cord-015021-pol2qm74	3630	8	TNF	TNF	NNP
cord-015021-pol2qm74	3630	9	in	in	IN
cord-015021-pol2qm74	3630	10	sepsis	sepsis	NN
cord-015021-pol2qm74	3630	11	and	and	CC
cord-015021-pol2qm74	3630	12	MODS	mods	NN
cord-015021-pol2qm74	3630	13	we	-PRON-	PRP
cord-015021-pol2qm74	3630	14	measured	measure	VBD
cord-015021-pol2qm74	3630	15	TNF	TNF	NNP
cord-015021-pol2qm74	3630	16	and	and	CC
cord-015021-pol2qm74	3630	17	sTNFR	stnfr	RB
cord-015021-pol2qm74	3630	18	-	-	HYPH
cord-015021-pol2qm74	3630	19	I	-PRON-	PRP
cord-015021-pol2qm74	3630	20	levels	level	NNS
cord-015021-pol2qm74	3630	21	in	in	IN
cord-015021-pol2qm74	3630	22	septic	septic	JJ
cord-015021-pol2qm74	3630	23	patients	patient	NNS
cord-015021-pol2qm74	3630	24	and	and	CC
cord-015021-pol2qm74	3630	25	investigated	investigate	VBN
cord-015021-pol2qm74	3630	26	if	if	IN
cord-015021-pol2qm74	3630	27	there	there	EX
cord-015021-pol2qm74	3630	28	is	be	VBZ
cord-015021-pol2qm74	3630	29	a	a	DT
cord-015021-pol2qm74	3630	30	relation	relation	NN
cord-015021-pol2qm74	3630	31	between	between	IN
cord-015021-pol2qm74	3630	32	plasma	plasma	NN
cord-015021-pol2qm74	3630	33	concentration	concentration	NN
cord-015021-pol2qm74	3630	34	of	of	IN
cord-015021-pol2qm74	3630	35	these	these	DT
cord-015021-pol2qm74	3630	36	molecules	molecule	NNS
cord-015021-pol2qm74	3630	37	and	and	CC
cord-015021-pol2qm74	3630	38	the	the	DT
cord-015021-pol2qm74	3630	39	severity	severity	NN
cord-015021-pol2qm74	3630	40	of	of	IN
cord-015021-pol2qm74	3630	41	sepsis	sepsis	NN
cord-015021-pol2qm74	3630	42	evaluated	evaluate	VBN
cord-015021-pol2qm74	3630	43	by	by	IN
cord-015021-pol2qm74	3630	44	two	two	CD
cord-015021-pol2qm74	3630	45	scores	score	NNS
cord-015021-pol2qm74	3630	46	(	(	-LRB-
cord-015021-pol2qm74	3630	47	APACHE	APACHE	NNP
cord-015021-pol2qm74	3630	48	1I	1I	NNP
cord-015021-pol2qm74	3630	49	and	and	CC
cord-015021-pol2qm74	3630	50	SSS	SSS	NNP
cord-015021-pol2qm74	3630	51	)	)	-RRB-
cord-015021-pol2qm74	3630	52	.	.	.
cord-015021-pol2qm74	3631	1	Patients	Patients	NNP
cord-015021-pol2qm74	3631	2	and	and	CC
cord-015021-pol2qm74	3631	3	Melhods	Melhods	NNP
cord-015021-pol2qm74	3631	4	:	:	:
cord-015021-pol2qm74	3631	5	20	20	CD
cord-015021-pol2qm74	3631	6	septic	septic	JJ
cord-015021-pol2qm74	3631	7	patients	patient	NNS
cord-015021-pol2qm74	3631	8	fullfilling	fullfille	VBG
cord-015021-pol2qm74	3631	9	sepsis	sepsis	NN
cord-015021-pol2qm74	3631	10	criteria	criterion	NNS
cord-015021-pol2qm74	3631	11	of	of	IN
cord-015021-pol2qm74	3631	12	American	American	NNP
cord-015021-pol2qm74	3631	13	College	College	NNP
cord-015021-pol2qm74	3631	14	of	of	IN
cord-015021-pol2qm74	3631	15	Chest	Chest	NNP
cord-015021-pol2qm74	3631	16	Physician	Physician	NNP
cord-015021-pol2qm74	3631	17	and	and	CC
cord-015021-pol2qm74	3631	18	Society	Society	NNP
cord-015021-pol2qm74	3631	19	of	of	IN
cord-015021-pol2qm74	3631	20	Critical	Critical	NNP
cord-015021-pol2qm74	3631	21	Care	Care	NNP
cord-015021-pol2qm74	3631	22	Medicine	Medicine	NNP
cord-015021-pol2qm74	3631	23	were	be	VBD
cord-015021-pol2qm74	3631	24	studied	study	VBN
cord-015021-pol2qm74	3631	25	.	.	.
cord-015021-pol2qm74	3632	1	TNF	TNF	NNP
cord-015021-pol2qm74	3632	2	-	-	HYPH
cord-015021-pol2qm74	3632	3	cc	cc	NNP
cord-015021-pol2qm74	3632	4	and	and	CC
cord-015021-pol2qm74	3632	5	STNFR	STNFR	NNP
cord-015021-pol2qm74	3632	6	-	-	HYPH
cord-015021-pol2qm74	3632	7	I	I	NNP
cord-015021-pol2qm74	3632	8	(	(	-LRB-
cord-015021-pol2qm74	3632	9	60kDa	60kDa	NNP
cord-015021-pol2qm74	3632	10	)	)	-RRB-
cord-015021-pol2qm74	3632	11	were	be	VBD
cord-015021-pol2qm74	3632	12	measured	measure	VBN
cord-015021-pol2qm74	3632	13	by	by	IN
cord-015021-pol2qm74	3632	14	enzyme	enzyme	NN
cord-015021-pol2qm74	3632	15	immuneassays	immuneassay	NNS
cord-015021-pol2qm74	3632	16	(	(	-LRB-
cord-015021-pol2qm74	3632	17	norms1	norms1	NNP
cord-015021-pol2qm74	3632	18	values	value	NNS
cord-015021-pol2qm74	3632	19	=	=	.
cord-015021-pol2qm74	3633	1	13	13	CD
cord-015021-pol2qm74	3633	2	+	+	SYM
cord-015021-pol2qm74	3633	3	8	8	CD
cord-015021-pol2qm74	3633	4	pg	pg	NN
cord-015021-pol2qm74	3633	5	/	/	SYM
cord-015021-pol2qm74	3633	6	mL	ml	NN
cord-015021-pol2qm74	3633	7	and	and	CC
cord-015021-pol2qm74	3633	8	1.06_+0A	1.06_+0a	CD
cord-015021-pol2qm74	3633	9	ng	ng	NN
cord-015021-pol2qm74	3633	10	/	/	SYM
cord-015021-pol2qm74	3633	11	mL	ml	NN
cord-015021-pol2qm74	3633	12	respectively	respectively	RB
cord-015021-pol2qm74	3633	13	)	)	-RRB-
cord-015021-pol2qm74	3633	14	.	.	.
cord-015021-pol2qm74	3634	1	Results	result	NNS
cord-015021-pol2qm74	3634	2	:	:	:
cord-015021-pol2qm74	3635	1	The	the	DT
cord-015021-pol2qm74	3635	2	mean	mean	JJ
cord-015021-pol2qm74	3635	3	TNF	TNF	NNP
cord-015021-pol2qm74	3635	4	and	and	CC
cord-015021-pol2qm74	3635	5	sTNFR	stnfr	RB
cord-015021-pol2qm74	3635	6	-	-	HYPH
cord-015021-pol2qm74	3635	7	I	-PRON-	PRP
cord-015021-pol2qm74	3635	8	values	value	NNS
cord-015021-pol2qm74	3635	9	for	for	IN
cord-015021-pol2qm74	3635	10	each	each	DT
cord-015021-pol2qm74	3635	11	patient	patient	NN
cord-015021-pol2qm74	3635	12	(	(	-LRB-
cord-015021-pol2qm74	3635	13	mean+SD	mean+SD	NNP
cord-015021-pol2qm74	3635	14	)	)	-RRB-
cord-015021-pol2qm74	3635	15	were	be	VBD
cord-015021-pol2qm74	3635	16	93	93	CD
cord-015021-pol2qm74	3635	17	+	+	SYM
cord-015021-pol2qm74	3635	18	64	64	CD
cord-015021-pol2qm74	3635	19	pg	pg	NN
cord-015021-pol2qm74	3635	20	/	/	SYM
cord-015021-pol2qm74	3635	21	mL	ml	NN
cord-015021-pol2qm74	3635	22	and	and	CC
cord-015021-pol2qm74	3636	1	11.1	11.1	CD
cord-015021-pol2qm74	3636	2	+	+	SYM
cord-015021-pol2qm74	3636	3	5.5	5.5	CD
cord-015021-pol2qm74	3636	4	ng	ng	NN
cord-015021-pol2qm74	3636	5	/	/	SYM
cord-015021-pol2qm74	3636	6	mL	ml	NN
cord-015021-pol2qm74	3636	7	respectively	respectively	RB
cord-015021-pol2qm74	3636	8	.	.	.
cord-015021-pol2qm74	3637	1	These	these	DT
cord-015021-pol2qm74	3637	2	values	value	NNS
cord-015021-pol2qm74	3637	3	are	be	VBP
cord-015021-pol2qm74	3637	4	approximately	approximately	RB
cord-015021-pol2qm74	3637	5	seven	seven	CD
cord-015021-pol2qm74	3637	6	and	and	CC
cord-015021-pol2qm74	3637	7	ten	ten	CD
cord-015021-pol2qm74	3637	8	times	time	NNS
cord-015021-pol2qm74	3637	9	greater	great	JJR
cord-015021-pol2qm74	3637	10	than	than	IN
cord-015021-pol2qm74	3637	11	those	those	DT
cord-015021-pol2qm74	3637	12	observed	observe	VBN
cord-015021-pol2qm74	3637	13	in	in	IN
cord-015021-pol2qm74	3637	14	normal	normal	JJ
cord-015021-pol2qm74	3637	15	healthy	healthy	JJ
cord-015021-pol2qm74	3637	16	volunteers	volunteer	NNS
cord-015021-pol2qm74	3637	17	(	(	-LRB-
cord-015021-pol2qm74	3637	18	P<0.001	P<0.001	NNP
cord-015021-pol2qm74	3637	19	)	)	-RRB-
cord-015021-pol2qm74	3637	20	.	.	.
cord-015021-pol2qm74	3638	1	Mean	Mean	NNP
cord-015021-pol2qm74	3638	2	TNF	TNF	NNP
cord-015021-pol2qm74	3638	3	concentrations	concentration	NNS
cord-015021-pol2qm74	3638	4	for	for	IN
cord-015021-pol2qm74	3638	5	each	each	DT
cord-015021-pol2qm74	3638	6	patient	patient	NN
cord-015021-pol2qm74	3638	7	were	be	VBD
cord-015021-pol2qm74	3638	8	significantly	significantly	RB
cord-015021-pol2qm74	3638	9	greater	great	JJR
cord-015021-pol2qm74	3638	10	in	in	IN
cord-015021-pol2qm74	3638	11	non	non	JJ
cord-015021-pol2qm74	3638	12	survivors	survivor	NNS
cord-015021-pol2qm74	3638	13	(	(	-LRB-
cord-015021-pol2qm74	3638	14	112	112	CD
cord-015021-pol2qm74	3638	15	+	+	SYM
cord-015021-pol2qm74	3638	16	52	52	CD
cord-015021-pol2qm74	3638	17	vs	vs	IN
cord-015021-pol2qm74	3638	18	64_+74	64_+74	CD
cord-015021-pol2qm74	3638	19	pg	pg	NNP
cord-015021-pol2qm74	3638	20	/	/	SYM
cord-015021-pol2qm74	3638	21	ml	ml	NN
cord-015021-pol2qm74	3638	22	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	3638	23	)	)	-RRB-
cord-015021-pol2qm74	3638	24	;	;	:
cord-015021-pol2qm74	3638	25	sTNFR	stnfr	RBR
cord-015021-pol2qm74	3638	26	-	-	HYPH
cord-015021-pol2qm74	3638	27	I	-PRON-	PRP
cord-015021-pol2qm74	3638	28	levels	level	NNS
cord-015021-pol2qm74	3638	29	also	also	RB
cord-015021-pol2qm74	3638	30	were	be	VBD
cord-015021-pol2qm74	3638	31	greater	great	JJR
cord-015021-pol2qm74	3638	32	in	in	IN
cord-015021-pol2qm74	3638	33	this	this	DT
cord-015021-pol2qm74	3638	34	group	group	NN
cord-015021-pol2qm74	3638	35	,	,	,
cord-015021-pol2qm74	3638	36	but	but	CC
cord-015021-pol2qm74	3638	37	the	the	DT
cord-015021-pol2qm74	3638	38	difference	difference	NN
cord-015021-pol2qm74	3638	39	was	be	VBD
cord-015021-pol2qm74	3638	40	not	not	RB
cord-015021-pol2qm74	3638	41	statistically	statistically	RB
cord-015021-pol2qm74	3638	42	significant	significant	JJ
cord-015021-pol2qm74	3638	43	(	(	-LRB-
cord-015021-pol2qm74	3638	44	12.6	12.6	CD
cord-015021-pol2qm74	3638	45	+	+	SYM
cord-015021-pol2qm74	3638	46	5.2	5.2	CD
cord-015021-pol2qm74	3638	47	vs	vs	IN
cord-015021-pol2qm74	3638	48	8.8_+5.5	8.8_+5.5	CD
cord-015021-pol2qm74	3638	49	ng	ng	NNP
cord-015021-pol2qm74	3638	50	/	/	SYM
cord-015021-pol2qm74	3638	51	ml	ml	NN
cord-015021-pol2qm74	3638	52	)	)	-RRB-
cord-015021-pol2qm74	3638	53	.	.	.
cord-015021-pol2qm74	3639	1	Plasma	Plasma	NNP
cord-015021-pol2qm74	3639	2	TNF	TNF	NNP
cord-015021-pol2qm74	3639	3	and	and	CC
cord-015021-pol2qm74	3639	4	sTNFR	stnfr	RB
cord-015021-pol2qm74	3639	5	-	-	HYPH
cord-015021-pol2qm74	3639	6	I	-PRON-	PRP
cord-015021-pol2qm74	3639	7	concentrations	concentration	NNS
cord-015021-pol2qm74	3639	8	were	be	VBD
cord-015021-pol2qm74	3639	9	significantly	significantly	RB
cord-015021-pol2qm74	3639	10	correlated	correlate	VBN
cord-015021-pol2qm74	3639	11	(	(	-LRB-
cord-015021-pol2qm74	3639	12	r	r	NN
cord-015021-pol2qm74	3639	13	=	=	NN
cord-015021-pol2qm74	3639	14	0.65	0.65	CD
cord-015021-pol2qm74	3639	15	P<0.005	P<0.005	NNP
cord-015021-pol2qm74	3639	16	)	)	-RRB-
cord-015021-pol2qm74	3639	17	.	.	.
cord-015021-pol2qm74	3640	1	Mean	mean	JJ
cord-015021-pol2qm74	3640	2	TNF	TNF	NNP
cord-015021-pol2qm74	3640	3	levels	level	NNS
cord-015021-pol2qm74	3640	4	were	be	VBD
cord-015021-pol2qm74	3640	5	significantly	significantly	RB
cord-015021-pol2qm74	3640	6	correlated	correlate	VBN
cord-015021-pol2qm74	3640	7	with	with	IN
cord-015021-pol2qm74	3640	8	APACHE	APACHE	NNP
cord-015021-pol2qm74	3640	9	II	II	NNP
cord-015021-pol2qm74	3640	10	(	(	-LRB-
cord-015021-pol2qm74	3640	11	r	r	NN
cord-015021-pol2qm74	3640	12	=	=	SYM
cord-015021-pol2qm74	3640	13	0.49	0.49	CD
cord-015021-pol2qm74	3640	14	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	3640	15	)	)	-RRB-
cord-015021-pol2qm74	3640	16	and	and	CC
cord-015021-pol2qm74	3640	17	SSS	SSS	NNP
cord-015021-pol2qm74	3640	18	(	(	-LRB-
cord-015021-pol2qm74	3640	19	r	r	NN
cord-015021-pol2qm74	3640	20	=	=	NN
cord-015021-pol2qm74	3640	21	0.54	0.54	CD
cord-015021-pol2qm74	3640	22	P	p	NN
cord-015021-pol2qm74	3640	23	<	<	XX
cord-015021-pol2qm74	3640	24	O.01	o.01	CD
cord-015021-pol2qm74	3640	25	)	)	-RRB-
cord-015021-pol2qm74	3640	26	;	;	:
cord-015021-pol2qm74	3640	27	sTNFR	stnfr	RBR
cord-015021-pol2qm74	3640	28	-	-	HYPH
cord-015021-pol2qm74	3640	29	I	-PRON-	PRP
cord-015021-pol2qm74	3640	30	levels	level	NNS
cord-015021-pol2qm74	3640	31	were	be	VBD
cord-015021-pol2qm74	3640	32	likewise	likewise	RB
cord-015021-pol2qm74	3640	33	correlated	correlate	VBN
cord-015021-pol2qm74	3640	34	with	with	IN
cord-015021-pol2qm74	3640	35	both	both	DT
cord-015021-pol2qm74	3640	36	scores	score	NNS
cord-015021-pol2qm74	3640	37	(	(	-LRB-
cord-015021-pol2qm74	3640	38	r	r	NN
cord-015021-pol2qm74	3640	39	=	=	NN
cord-015021-pol2qm74	3640	40	0.80	0.80	CD
cord-015021-pol2qm74	3640	41	P<0.001	P<0.001	NNS
cord-015021-pol2qm74	3640	42	and	and	CC
cord-015021-pol2qm74	3640	43	r	r	NN
cord-015021-pol2qm74	3640	44	=	=	SYM
cord-015021-pol2qm74	3640	45	0.76	0.76	CD
cord-015021-pol2qm74	3640	46	P<0.001	P<0.001	NNS
cord-015021-pol2qm74	3640	47	respectively	respectively	RB
cord-015021-pol2qm74	3640	48	)	)	-RRB-
cord-015021-pol2qm74	3640	49	.	.	.
cord-015021-pol2qm74	3641	1	TNF	TNF	NNP
cord-015021-pol2qm74	3641	2	and	and	CC
cord-015021-pol2qm74	3641	3	sTNFqGI	stnfqgi	NN
cord-015021-pol2qm74	3641	4	levels	level	NNS
cord-015021-pol2qm74	3641	5	increase	increase	VBP
cord-015021-pol2qm74	3641	6	with	with	IN
cord-015021-pol2qm74	3641	7	the	the	DT
cord-015021-pol2qm74	3641	8	number	number	NN
cord-015021-pol2qm74	3641	9	of	of	IN
cord-015021-pol2qm74	3641	10	dysfuctional	dysfuctional	JJ
cord-015021-pol2qm74	3641	11	organs	organ	NNS
cord-015021-pol2qm74	3641	12	;	;	:
cord-015021-pol2qm74	3641	13	in	in	IN
cord-015021-pol2qm74	3641	14	particular	particular	JJ
cord-015021-pol2qm74	3641	15	TNF	TNF	NNP
cord-015021-pol2qm74	3641	16	and	and	CC
cord-015021-pol2qm74	3641	17	STNFR	STNFR	NNP
cord-015021-pol2qm74	3641	18	-	-	:
cord-015021-pol2qm74	3641	19	I	-PRON-	PRP
cord-015021-pol2qm74	3641	20	increase	increase	VBP
cord-015021-pol2qm74	3641	21	when	when	WRB
cord-015021-pol2qm74	3641	22	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	3641	23	deteriorate	deteriorate	VBP
cord-015021-pol2qm74	3641	24	and	and	CC
cord-015021-pol2qm74	3641	25	kidney	kidney	NN
cord-015021-pol2qm74	3641	26	failure	failure	NN
cord-015021-pol2qm74	3641	27	ensues	ensue	VBZ
cord-015021-pol2qm74	3641	28	.	.	.
cord-015021-pol2qm74	3642	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3642	2	:	:	:
cord-015021-pol2qm74	3643	1	The	the	DT
cord-015021-pol2qm74	3643	2	correlations	correlation	NNS
cord-015021-pol2qm74	3643	3	between	between	IN
cord-015021-pol2qm74	3643	4	TNF	TNF	NNP
cord-015021-pol2qm74	3643	5	and	and	CC
cord-015021-pol2qm74	3643	6	sTNFR	stnfr	RB
cord-015021-pol2qm74	3643	7	-	-	HYPH
cord-015021-pol2qm74	3643	8	I	-PRON-	PRP
cord-015021-pol2qm74	3643	9	levels	level	NNS
cord-015021-pol2qm74	3643	10	and	and	CC
cord-015021-pol2qm74	3643	11	sepsis	sepsis	NN
cord-015021-pol2qm74	3643	12	severity	severity	NN
cord-015021-pol2qm74	3643	13	scores	score	NNS
cord-015021-pol2qm74	3643	14	suggests	suggest	VBZ
cord-015021-pol2qm74	3643	15	that	that	IN
cord-015021-pol2qm74	3643	16	TNF	TNF	NNP
cord-015021-pol2qm74	3643	17	is	be	VBZ
cord-015021-pol2qm74	3643	18	involved	involve	VBN
cord-015021-pol2qm74	3643	19	in	in	IN
cord-015021-pol2qm74	3643	20	sepsis	sepsis	NN
cord-015021-pol2qm74	3643	21	and	and	CC
cord-015021-pol2qm74	3643	22	may	may	MD
cord-015021-pol2qm74	3643	23	influence	influence	VB
cord-015021-pol2qm74	3643	24	the	the	DT
cord-015021-pol2qm74	3643	25	occurrence	occurrence	NN
cord-015021-pol2qm74	3643	26	of	of	IN
cord-015021-pol2qm74	3643	27	MODS	mods	NN
cord-015021-pol2qm74	3643	28	and	and	CC
cord-015021-pol2qm74	3643	29	finally	finally	RB
cord-015021-pol2qm74	3643	30	clinical	clinical	JJ
cord-015021-pol2qm74	3643	31	outcome	outcome	NN
cord-015021-pol2qm74	3643	32	.	.	.
cord-015021-pol2qm74	3644	1	TNF	TNF	NNP
cord-015021-pol2qm74	3644	2	and	and	CC
cord-015021-pol2qm74	3644	3	sTNFR	sTNFR	NNP
cord-015021-pol2qm74	3645	1	-I	-I	NNP
cord-015021-pol2qm74	3645	2	are	be	VBP
cord-015021-pol2qm74	3645	3	in	in	IN
cord-015021-pol2qm74	3645	4	fact	fact	NN
cord-015021-pol2qm74	3645	5	especially	especially	RB
cord-015021-pol2qm74	3645	6	increased	increase	VBN
cord-015021-pol2qm74	3645	7	when	when	WRB
cord-015021-pol2qm74	3645	8	MODS	mods	NN
cord-015021-pol2qm74	3645	9	occurs	occur	VBZ
cord-015021-pol2qm74	3645	10	.	.	.
cord-015021-pol2qm74	3646	1	In	in	IN
cord-015021-pol2qm74	3646	2	particular	particular	JJ
cord-015021-pol2qm74	3646	3	their	-PRON-	PRP$
cord-015021-pol2qm74	3646	4	concentrations	concentration	NNS
cord-015021-pol2qm74	3646	5	are	be	VBP
cord-015021-pol2qm74	3646	6	elevated	elevate	VBN
cord-015021-pol2qm74	3646	7	when	when	WRB
cord-015021-pol2qm74	3646	8	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	3646	9	system	system	NN
cord-015021-pol2qm74	3646	10	and	and	CC
cord-015021-pol2qm74	3646	11	kidney	kidney	NN
cord-015021-pol2qm74	3646	12	failure	failure	NN
cord-015021-pol2qm74	3646	13	ensue	ensue	NN
cord-015021-pol2qm74	3646	14	,	,	,
cord-015021-pol2qm74	3646	15	suggesting	suggest	VBG
cord-015021-pol2qm74	3646	16	that	that	IN
cord-015021-pol2qm74	3646	17	TNF	TNF	NNP
cord-015021-pol2qm74	3646	18	can	can	MD
cord-015021-pol2qm74	3646	19	have	have	VB
cord-015021-pol2qm74	3646	20	a	a	DT
cord-015021-pol2qm74	3646	21	direct	direct	JJ
cord-015021-pol2qm74	3646	22	role	role	NN
cord-015021-pol2qm74	3646	23	in	in	IN
cord-015021-pol2qm74	3646	24	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	3646	25	derangements	derangement	NNS
cord-015021-pol2qm74	3646	26	caused	cause	VBN
cord-015021-pol2qm74	3646	27	by	by	IN
cord-015021-pol2qm74	3646	28	sepsis	sepsis	NN
cord-015021-pol2qm74	3646	29	and	and	CC
cord-015021-pol2qm74	3646	30	that	that	IN
cord-015021-pol2qm74	3646	31	kidneys	kidney	NNS
cord-015021-pol2qm74	3646	32	are	be	VBP
cord-015021-pol2qm74	3646	33	involved	involve	VBN
cord-015021-pol2qm74	3646	34	in	in	IN
cord-015021-pol2qm74	3646	35	TNF	TNF	NNP
cord-015021-pol2qm74	3646	36	and	and	CC
cord-015021-pol2qm74	3646	37	sTNFR	stnfr	RB
cord-015021-pol2qm74	3646	38	-	-	:
cord-015021-pol2qm74	3646	39	I	-PRON-	PRP
cord-015021-pol2qm74	3646	40	excretion	excretion	NN
cord-015021-pol2qm74	3646	41	.	.	.
cord-015021-pol2qm74	3647	1	LIF	LIF	NNP
cord-015021-pol2qm74	3647	2	is	be	VBZ
cord-015021-pol2qm74	3647	3	a	a	DT
cord-015021-pol2qm74	3647	4	pleiotropic	pleiotropic	JJ
cord-015021-pol2qm74	3647	5	cytokine	cytokine	NN
cord-015021-pol2qm74	3647	6	that	that	WDT
cord-015021-pol2qm74	3647	7	has	have	VBZ
cord-015021-pol2qm74	3647	8	been	be	VBN
cord-015021-pol2qm74	3647	9	implicated	implicate	VBN
cord-015021-pol2qm74	3647	10	in	in	IN
cord-015021-pol2qm74	3647	11	the	the	DT
cord-015021-pol2qm74	3647	12	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	3647	13	of	of	IN
cord-015021-pol2qm74	3647	14	sepsis	sepsis	NN
cord-015021-pol2qm74	3647	15	in	in	IN
cord-015021-pol2qm74	3647	16	animal	animal	NN
cord-015021-pol2qm74	3647	17	models	model	NNS
cord-015021-pol2qm74	3647	18	.	.	.
cord-015021-pol2qm74	3648	1	We	-PRON-	PRP
cord-015021-pol2qm74	3648	2	conducted	conduct	VBD
cord-015021-pol2qm74	3648	3	a	a	DT
cord-015021-pol2qm74	3648	4	prospective	prospective	JJ
cord-015021-pol2qm74	3648	5	study	study	NN
cord-015021-pol2qm74	3648	6	in	in	IN
cord-015021-pol2qm74	3648	7	33	33	CD
cord-015021-pol2qm74	3648	8	septic	septic	JJ
cord-015021-pol2qm74	3648	9	patients	patient	NNS
cord-015021-pol2qm74	3648	10	to	to	TO
cord-015021-pol2qm74	3648	11	correlate	correlate	VB
cord-015021-pol2qm74	3648	12	LIF	LIF	NNP
cord-015021-pol2qm74	3648	13	plasma	plasma	NN
cord-015021-pol2qm74	3648	14	levels	level	NNS
cord-015021-pol2qm74	3648	15	with	with	IN
cord-015021-pol2qm74	3648	16	patient	patient	NN
cord-015021-pol2qm74	3648	17	's	's	POS
cord-015021-pol2qm74	3648	18	clinical	clinical	JJ
cord-015021-pol2qm74	3648	19	and	and	CC
cord-015021-pol2qm74	3648	20	biological	biological	JJ
cord-015021-pol2qm74	3648	21	data	datum	NNS
cord-015021-pol2qm74	3648	22	(	(	-LRB-
cord-015021-pol2qm74	3648	23	among	among	IN
cord-015021-pol2qm74	3648	24	them	-PRON-	PRP
cord-015021-pol2qm74	3648	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	3648	26	)	)	-RRB-
cord-015021-pol2qm74	3648	27	.	.	.
cord-015021-pol2qm74	3649	1	Plasma	plasma	NN
cord-015021-pol2qm74	3649	2	was	be	VBD
cord-015021-pol2qm74	3649	3	drawn	draw	VBN
cord-015021-pol2qm74	3649	4	daily	daily	RB
cord-015021-pol2qm74	3649	5	from	from	IN
cord-015021-pol2qm74	3649	6	day	day	NN
cord-015021-pol2qm74	3649	7	one	one	CD
cord-015021-pol2qm74	3649	8	to	to	IN
cord-015021-pol2qm74	3649	9	.ten	.ten	.
cord-015021-pol2qm74	3650	1	and	and	CC
cord-015021-pol2qm74	3650	2	LIF	LIF	NNP
cord-015021-pol2qm74	3650	3	presence	presence	NN
cord-015021-pol2qm74	3650	4	was	be	VBD
cord-015021-pol2qm74	3650	5	determined	determine	VBN
cord-015021-pol2qm74	3650	6	with	with	IN
cord-015021-pol2qm74	3650	7	a	a	DT
cord-015021-pol2qm74	3650	8	specific	specific	JJ
cord-015021-pol2qm74	3650	9	ELISA	ELISA	NNP
cord-015021-pol2qm74	3650	10	and	and	CC
cord-015021-pol2qm74	3650	11	with	with	IN
cord-015021-pol2qm74	3650	12	the	the	DT
cord-015021-pol2qm74	3650	13	DAI	DAI	NNP
cord-015021-pol2qm74	3650	14	,	,	,
cord-015021-pol2qm74	3650	15	a	a	DT
cord-015021-pol2qm74	3650	16	bioassay	bioassay	NN
cord-015021-pol2qm74	3650	17	(	(	-LRB-
cord-015021-pol2qm74	3650	18	sensitivity	sensitivity	NN
cord-015021-pol2qm74	3650	19	of	of	IN
cord-015021-pol2qm74	3650	20	100	100	CD
cord-015021-pol2qm74	3650	21	pg	pg	NN
cord-015021-pol2qm74	3650	22	/	/	SYM
cord-015021-pol2qm74	3650	23	ml	ml	NN
cord-015021-pol2qm74	3650	24	and	and	CC
cord-015021-pol2qm74	3650	25	1	1	CD
cord-015021-pol2qm74	3650	26	ngml	ngml	NNP
cord-015021-pol2qm74	3650	27	respectively	respectively	RB
cord-015021-pol2qm74	3650	28	)	)	-RRB-
cord-015021-pol2qm74	3650	29	.	.	.
cord-015021-pol2qm74	3651	1	Risk	risk	NN
cord-015021-pol2qm74	3651	2	factor	factor	NN
cord-015021-pol2qm74	3651	3	associated	associate	VBN
cord-015021-pol2qm74	3652	1	wftt~	wftt~	NNP
cord-015021-pol2qm74	3652	2	with	with	IN
cord-015021-pol2qm74	3652	3	elevated	elevated	JJ
cord-015021-pol2qm74	3652	4	LIF	LIF	NNP
cord-015021-pol2qm74	3652	5	plasma	plasma	NN
cord-015021-pol2qm74	3652	6	level	level	NN
cord-015021-pol2qm74	3652	7	was	be	VBD
cord-015021-pol2qm74	3652	8	determined	determine	VBN
cord-015021-pol2qm74	3652	9	by	by	IN
cord-015021-pol2qm74	3652	10	an	an	DT
cord-015021-pol2qm74	3652	11	univariate	univariate	JJ
cord-015021-pol2qm74	3652	12	analysis	analysis	NN
cord-015021-pol2qm74	3652	13	.	.	.
cord-015021-pol2qm74	3653	1	A	a	DT
cord-015021-pol2qm74	3653	2	multivariate	multivariate	JJ
cord-015021-pol2qm74	3653	3	stepwise	stepwise	JJ
cord-015021-pol2qm74	3653	4	logistic	logistic	JJ
cord-015021-pol2qm74	3653	5	regression	regression	NN
cord-015021-pol2qm74	3653	6	analysis	analysis	NN
cord-015021-pol2qm74	3653	7	was	be	VBD
cord-015021-pol2qm74	3653	8	subsequently	subsequently	RB
cord-015021-pol2qm74	3653	9	performed	perform	VBN
cord-015021-pol2qm74	3653	10	with	with	IN
cord-015021-pol2qm74	3653	11	a	a	DT
cord-015021-pol2qm74	3653	12	BMDP	BMDP	NNP
cord-015021-pol2qm74	3653	13	statistical	statistical	JJ
cord-015021-pol2qm74	3653	14	software	software	NN
cord-015021-pol2qm74	3653	15	.	.	.
cord-015021-pol2qm74	3654	1	LIF	LIF	NNP
cord-015021-pol2qm74	3654	2	was	be	VBD
cord-015021-pol2qm74	3654	3	detected	detect	VBN
cord-015021-pol2qm74	3654	4	with	with	IN
cord-015021-pol2qm74	3654	5	the	the	DT
cord-015021-pol2qm74	3654	6	ELISA	ELISA	NNP
cord-015021-pol2qm74	3654	7	and	and	CC
cord-015021-pol2qm74	3654	8	with	with	IN
cord-015021-pol2qm74	3654	9	the	the	DT
cord-015021-pol2qm74	3654	10	bioassay	bioassay	NN
cord-015021-pol2qm74	3654	11	in	in	IN
cord-015021-pol2qm74	3654	12	11	11	CD
cord-015021-pol2qm74	3654	13	and	and	CC
cord-015021-pol2qm74	3654	14	2	2	CD
cord-015021-pol2qm74	3654	15	out	out	IN
cord-015021-pol2qm74	3654	16	of	of	IN
cord-015021-pol2qm74	3654	17	the	the	DT
cord-015021-pol2qm74	3654	18	33	33	CD
cord-015021-pol2qm74	3654	19	patients	patient	NNS
cord-015021-pol2qm74	3654	20	,	,	,
cord-015021-pol2qm74	3654	21	respectively	respectively	RB
cord-015021-pol2qm74	3654	22	.	.	.
cord-015021-pol2qm74	3655	1	LIF	LIF	NNP
cord-015021-pol2qm74	3655	2	peak	peak	NN
cord-015021-pol2qm74	3655	3	plasma	plasma	NN
cord-015021-pol2qm74	3655	4	levels	level	NNS
cord-015021-pol2qm74	3655	5	were	be	VBD
cord-015021-pol2qm74	3655	6	statistically	statistically	RB
cord-015021-pol2qm74	3655	7	associated	associate	VBN
cord-015021-pol2qm74	3655	8	with	with	IN
cord-015021-pol2qm74	3655	9	high	high	JJ
cord-015021-pol2qm74	3655	10	creatmin	creatmin	JJ
cord-015021-pol2qm74	3655	11	levels	level	NNS
cord-015021-pol2qm74	3655	12	,	,	,
cord-015021-pol2qm74	3655	13	temperature	temperature	NN
cord-015021-pol2qm74	3655	14	and	and	CC
cord-015021-pol2qm74	3655	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	3655	16	.	.	.
cord-015021-pol2qm74	3656	1	Multivariate	multivariate	JJ
cord-015021-pol2qm74	3656	2	regression	regression	NN
cord-015021-pol2qm74	3656	3	analysis	analysis	NN
cord-015021-pol2qm74	3656	4	showed	show	VBD
cord-015021-pol2qm74	3656	5	that	that	IN
cord-015021-pol2qm74	3656	6	high	high	JJ
cord-015021-pol2qm74	3656	7	serum	serum	NN
cord-015021-pol2qm74	3656	8	creatinin	creatinin	NNS
cord-015021-pol2qm74	3656	9	level	level	NN
cord-015021-pol2qm74	3656	10	was	be	VBD
cord-015021-pol2qm74	3656	11	the	the	DT
cord-015021-pol2qm74	3656	12	major	major	JJ
cord-015021-pol2qm74	3656	13	independent	independent	JJ
cord-015021-pol2qm74	3656	14	risk	risk	NN
cord-015021-pol2qm74	3656	15	factor	factor	NN
cord-015021-pol2qm74	3656	16	associated	associate	VBN
cord-015021-pol2qm74	3656	17	with	with	IN
cord-015021-pol2qm74	3656	18	elevated	elevated	JJ
cord-015021-pol2qm74	3656	19	LIFplasma	LIFplasma	NNP
cord-015021-pol2qm74	3656	20	levels	level	NNS
cord-015021-pol2qm74	3656	21	.	.	.
cord-015021-pol2qm74	3657	1	This	this	DT
cord-015021-pol2qm74	3657	2	correlation	correlation	NN
cord-015021-pol2qm74	3657	3	was	be	VBD
cord-015021-pol2qm74	3657	4	also	also	RB
cord-015021-pol2qm74	3657	5	found	find	VBN
cord-015021-pol2qm74	3657	6	for	for	IN
cord-015021-pol2qm74	3657	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	3657	8	.	.	.
cord-015021-pol2qm74	3658	1	Peak	peak	NN
cord-015021-pol2qm74	3658	2	plasma	plasma	NN
cord-015021-pol2qm74	3658	3	levels	level	NNS
cord-015021-pol2qm74	3658	4	of	of	IN
cord-015021-pol2qm74	3658	5	both	both	CC
cord-015021-pol2qm74	3658	6	LIF	LIF	NNP
cord-015021-pol2qm74	3658	7	and	and	CC
cord-015021-pol2qm74	3658	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	3658	9	correlated	correlate	VBD
cord-015021-pol2qm74	3658	10	inversely	inversely	RB
cord-015021-pol2qm74	3658	11	with	with	IN
cord-015021-pol2qm74	3658	12	patients	patient	NNS
cord-015021-pol2qm74	3658	13	survival	survival	NN
cord-015021-pol2qm74	3658	14	duration	duration	NN
cord-015021-pol2qm74	3658	15	.	.	.
cord-015021-pol2qm74	3659	1	Cox	Cox	NNP
cord-015021-pol2qm74	3659	2	's	's	POS
cord-015021-pol2qm74	3659	3	analysis	analysis	NN
cord-015021-pol2qm74	3659	4	for	for	IN
cord-015021-pol2qm74	3659	5	plasma	plasma	NN
cord-015021-pol2qm74	3659	6	levels	level	NNS
cord-015021-pol2qm74	3659	7	of	of	IN
cord-015021-pol2qm74	3659	8	LIF	LIF	NNP
cord-015021-pol2qm74	3659	9	>	>	XX
cord-015021-pol2qm74	3660	1	480	480	CD
cord-015021-pol2qm74	3660	2	pg	pg	NN
cord-015021-pol2qm74	3660	3	/	/	SYM
cord-015021-pol2qm74	3660	4	ml	ml	CC
cord-015021-pol2qm74	3660	5	yelded	yelde	VBD
cord-015021-pol2qm74	3660	6	a	a	DT
cord-015021-pol2qm74	3660	7	hazard	hazard	NN
cord-015021-pol2qm74	3660	8	ratio	ratio	NN
cord-015021-pol2qm74	3660	9	of	of	IN
cord-015021-pol2qm74	3660	10	[	[	-LRB-
cord-015021-pol2qm74	3660	11	exp	exp	NN
cord-015021-pol2qm74	3660	12	(	(	-LRB-
cord-015021-pol2qm74	3660	13	1.86)=6.44	1.86)=6.44	CD
cord-015021-pol2qm74	3660	14	]	]	-RRB-
cord-015021-pol2qm74	3660	15	.	.	.
cord-015021-pol2qm74	3661	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3661	2	study	study	NN
cord-015021-pol2qm74	3661	3	indicates	indicate	VBZ
cord-015021-pol2qm74	3661	4	that	that	IN
cord-015021-pol2qm74	3661	5	LIF	LIF	NNP
cord-015021-pol2qm74	3661	6	levels	level	NNS
cord-015021-pol2qm74	3661	7	were	be	VBD
cord-015021-pol2qm74	3661	8	associated	associate	VBN
cord-015021-pol2qm74	3661	9	with	with	IN
cord-015021-pol2qm74	3661	10	clinical	clinical	JJ
cord-015021-pol2qm74	3661	11	and	and	CC
cord-015021-pol2qm74	3661	12	biological	biological	JJ
cord-015021-pol2qm74	3661	13	parameters	parameter	NNS
cord-015021-pol2qm74	3661	14	of	of	IN
cord-015021-pol2qm74	3661	15	illness	illness	NN
cord-015021-pol2qm74	3661	16	severity	severity	NN
cord-015021-pol2qm74	3661	17	and	and	CC
cord-015021-pol2qm74	3661	18	significantly	significantly	RB
cord-015021-pol2qm74	3661	19	increased	increase	VBD
cord-015021-pol2qm74	3661	20	(	(	-LRB-
cord-015021-pol2qm74	3661	21	cut	cut	VBN
cord-015021-pol2qm74	3661	22	-	-	HYPH
cord-015021-pol2qm74	3661	23	off	off	RP
cord-015021-pol2qm74	3661	24	value	value	NN
cord-015021-pol2qm74	3661	25	480	480	CD
cord-015021-pol2qm74	3661	26	pg	pg	NNP
cord-015021-pol2qm74	3661	27	/	/	SYM
cord-015021-pol2qm74	3661	28	mI	mI	NNP
cord-015021-pol2qm74	3661	29	)	)	-RRB-
cord-015021-pol2qm74	3661	30	in	in	IN
cord-015021-pol2qm74	3661	31	patients	patient	NNS
cord-015021-pol2qm74	3661	32	with	with	IN
cord-015021-pol2qm74	3661	33	fatal	fatal	JJ
cord-015021-pol2qm74	3661	34	outcome	outcome	NN
cord-015021-pol2qm74	3661	35	.	.	.
cord-015021-pol2qm74	3662	1	Current	current	JJ
cord-015021-pol2qm74	3662	2	consensus	consensus	NN
cord-015021-pol2qm74	3662	3	exists	exist	VBZ
cord-015021-pol2qm74	3662	4	about	about	IN
cord-015021-pol2qm74	3662	5	the	the	DT
cord-015021-pol2qm74	3662	6	central	central	JJ
cord-015021-pol2qm74	3662	7	role	role	NN
cord-015021-pol2qm74	3662	8	of	of	IN
cord-015021-pol2qm74	3662	9	tumor	tumor	NN
cord-015021-pol2qm74	3662	10	necrosis	necrosis	NN
cord-015021-pol2qm74	3662	11	factor	factor	NN
cord-015021-pol2qm74	3662	12	(	(	-LRB-
cord-015021-pol2qm74	3662	13	TNF	TNF	NNP
cord-015021-pol2qm74	3662	14	)	)	-RRB-
cord-015021-pol2qm74	3662	15	alpha	alpha	NN
cord-015021-pol2qm74	3662	16	in	in	IN
cord-015021-pol2qm74	3662	17	initiating	initiate	VBG
cord-015021-pol2qm74	3662	18	the	the	DT
cord-015021-pol2qm74	3662	19	systemic	systemic	JJ
cord-015021-pol2qm74	3662	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3662	21	response	response	NN
cord-015021-pol2qm74	3662	22	syndrome	syndrome	NN
cord-015021-pol2qm74	3662	23	(	(	-LRB-
cord-015021-pol2qm74	3662	24	SIRS	SIRS	NNP
cord-015021-pol2qm74	3662	25	)	)	-RRB-
cord-015021-pol2qm74	3662	26	.	.	.
cord-015021-pol2qm74	3663	1	A	a	DT
cord-015021-pol2qm74	3663	2	correlation	correlation	NN
cord-015021-pol2qm74	3663	3	with	with	IN
cord-015021-pol2qm74	3663	4	SIRS	SIRS	NNP
cord-015021-pol2qm74	3663	5	has	have	VBZ
cord-015021-pol2qm74	3663	6	inconsistently	inconsistently	RB
cord-015021-pol2qm74	3663	7	been	be	VBN
cord-015021-pol2qm74	3663	8	found	find	VBN
cord-015021-pol2qm74	3663	9	.	.	.
cord-015021-pol2qm74	3664	1	TNF	TNF	NNP
cord-015021-pol2qm74	3664	2	effects	effect	VBZ
cord-015021-pol2qm74	3664	3	its	-PRON-	PRP$
cord-015021-pol2qm74	3664	4	pleiotropic	pleiotropic	JJ
cord-015021-pol2qm74	3664	5	reactions	reaction	NNS
cord-015021-pol2qm74	3664	6	upon	upon	IN
cord-015021-pol2qm74	3664	7	two	two	CD
cord-015021-pol2qm74	3664	8	distinct	distinct	JJ
cord-015021-pol2qm74	3664	9	cellular	cellular	JJ
cord-015021-pol2qm74	3664	10	receptors	receptor	NNS
cord-015021-pol2qm74	3664	11	.	.	.
cord-015021-pol2qm74	3665	1	Soluble	soluble	JJ
cord-015021-pol2qm74	3665	2	extracel]ular	extracel]ular	JJ
cord-015021-pol2qm74	3665	3	fragments	fragment	NNS
cord-015021-pol2qm74	3665	4	of	of	IN
cord-015021-pol2qm74	3665	5	the	the	DT
cord-015021-pol2qm74	3665	6	human	human	JJ
cord-015021-pol2qm74	3665	7	55	55	CD
cord-015021-pol2qm74	3665	8	kDa	kDa	NNP
cord-015021-pol2qm74	3665	9	TNF	TNF	NNP
cord-015021-pol2qm74	3665	10	receptor	receptor	NN
cord-015021-pol2qm74	3665	11	(	(	-LRB-
cord-015021-pol2qm74	3665	12	sTNFRI	sTNFRI	NNP
cord-015021-pol2qm74	3665	13	)	)	-RRB-
cord-015021-pol2qm74	3665	14	and	and	CC
cord-015021-pol2qm74	3665	15	the	the	DT
cord-015021-pol2qm74	3665	16	75	75	CD
cord-015021-pol2qm74	3665	17	kDa	kDa	NNP
cord-015021-pol2qm74	3665	18	receptor	receptor	NN
cord-015021-pol2qm74	3665	19	(	(	-LRB-
cord-015021-pol2qm74	3665	20	sTNFRII	sTNFRII	NNP
cord-015021-pol2qm74	3665	21	)	)	-RRB-
cord-015021-pol2qm74	3665	22	are	be	VBP
cord-015021-pol2qm74	3665	23	detectable	detectable	JJ
cord-015021-pol2qm74	3665	24	in	in	IN
cord-015021-pol2qm74	3665	25	the	the	DT
cord-015021-pol2qm74	3665	26	circulation	circulation	NN
cord-015021-pol2qm74	3665	27	.	.	.
cord-015021-pol2qm74	3666	1	The	the	DT
cord-015021-pol2qm74	3666	2	kinetics	kinetic	NNS
cord-015021-pol2qm74	3666	3	of	of	IN
cord-015021-pol2qm74	3666	4	these	these	DT
cord-015021-pol2qm74	3666	5	endogenously	endogenously	RB
cord-015021-pol2qm74	3666	6	produced	produce	VBN
cord-015021-pol2qm74	3666	7	TNF	TNF	NNP
cord-015021-pol2qm74	3666	8	-	-	HYPH
cord-015021-pol2qm74	3666	9	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	3666	10	were	be	VBD
cord-015021-pol2qm74	3666	11	measured	measure	VBN
cord-015021-pol2qm74	3666	12	to	to	TO
cord-015021-pol2qm74	3666	13	evaluate	evaluate	VB
cord-015021-pol2qm74	3666	14	their	-PRON-	PRP$
cord-015021-pol2qm74	3666	15	role	role	NN
cord-015021-pol2qm74	3666	16	in	in	IN
cord-015021-pol2qm74	3666	17	patients	patient	NNS
cord-015021-pol2qm74	3666	18	with	with	IN
cord-015021-pol2qm74	3666	19	SIRS	SIRS	NNP
cord-015021-pol2qm74	3666	20	.	.	.
cord-015021-pol2qm74	3667	1	Fourteen	fourteen	CD
cord-015021-pol2qm74	3667	2	patients	patient	NNS
cord-015021-pol2qm74	3667	3	of	of	IN
cord-015021-pol2qm74	3667	4	an	an	DT
cord-015021-pol2qm74	3667	5	operative	operative	JJ
cord-015021-pol2qm74	3667	6	ICU	ICU	NNP
cord-015021-pol2qm74	3667	7	were	be	VBD
cord-015021-pol2qm74	3667	8	included	include	VBN
cord-015021-pol2qm74	3667	9	with	with	IN
cord-015021-pol2qm74	3667	10	the	the	DT
cord-015021-pol2qm74	3667	11	diagnossis	diagnossis	NN
cord-015021-pol2qm74	3667	12	of	of	IN
cord-015021-pol2qm74	3667	13	SIRS	SIRS	NNP
cord-015021-pol2qm74	3667	14	(	(	-LRB-
cord-015021-pol2qm74	3667	15	mean	mean	VB
cord-015021-pol2qm74	3667	16	APACHE	APACHE	NNP
cord-015021-pol2qm74	3667	17	II	II	NNP
cord-015021-pol2qm74	3667	18	score	score	NN
cord-015021-pol2qm74	3667	19	:	:	:
cord-015021-pol2qm74	3667	20	20	20	CD
cord-015021-pol2qm74	3667	21	points	point	NNS
cord-015021-pol2qm74	3667	22	)	)	-RRB-
cord-015021-pol2qm74	3667	23	.	.	.
cord-015021-pol2qm74	3668	1	Serial	serial	JJ
cord-015021-pol2qm74	3668	2	blood	blood	NN
cord-015021-pol2qm74	3668	3	samples	sample	NNS
cord-015021-pol2qm74	3668	4	were	be	VBD
cord-015021-pol2qm74	3668	5	obtained	obtain	VBN
cord-015021-pol2qm74	3668	6	within	within	IN
cord-015021-pol2qm74	3668	7	12	12	CD
cord-015021-pol2qm74	3668	8	h	h	NN
cord-015021-pol2qm74	3668	9	after	after	IN
cord-015021-pol2qm74	3668	10	diagnosis	diagnosis	NN
cord-015021-pol2qm74	3668	11	of	of	IN
cord-015021-pol2qm74	3668	12	SIRS	SIRS	NNP
cord-015021-pol2qm74	3668	13	,	,	,
cord-015021-pol2qm74	3668	14	every	every	DT
cord-015021-pol2qm74	3668	15	6	6	CD
cord-015021-pol2qm74	3668	16	hrs	hrs	NN
cord-015021-pol2qm74	3668	17	for	for	IN
cord-015021-pol2qm74	3668	18	the	the	DT
cord-015021-pol2qm74	3668	19	first	first	JJ
cord-015021-pol2qm74	3668	20	48	48	CD
cord-015021-pol2qm74	3668	21	hrs	hrs	NN
cord-015021-pol2qm74	3668	22	and	and	CC
cord-015021-pol2qm74	3668	23	every	every	DT
cord-015021-pol2qm74	3668	24	12	12	CD
cord-015021-pol2qm74	3668	25	hrs	hrs	NN
cord-015021-pol2qm74	3668	26	thereafter	thereafter	RB
cord-015021-pol2qm74	3668	27	until	until	IN
cord-015021-pol2qm74	3668	28	patients	patient	NNS
cord-015021-pol2qm74	3668	29	died	die	VBD
cord-015021-pol2qm74	3668	30	or	or	CC
cord-015021-pol2qm74	3668	31	recovered	recover	VBD
cord-015021-pol2qm74	3668	32	.	.	.
cord-015021-pol2qm74	3669	1	Soluble	soluble	JJ
cord-015021-pol2qm74	3669	2	TNFRI	TNFRI	NNP
cord-015021-pol2qm74	3669	3	and	and	CC
cord-015021-pol2qm74	3669	4	sTNFRII	sTNFRII	NNP
cord-015021-pol2qm74	3669	5	were	be	VBD
cord-015021-pol2qm74	3669	6	assayed	assay	VBN
cord-015021-pol2qm74	3669	7	by	by	IN
cord-015021-pol2qm74	3669	8	an	an	DT
cord-015021-pol2qm74	3669	9	enzymed	enzyme	VBN
cord-015021-pol2qm74	3669	10	-	-	HYPH
cord-015021-pol2qm74	3669	11	linked	link	VBN
cord-015021-pol2qm74	3669	12	immunological	immunological	JJ
cord-015021-pol2qm74	3669	13	binding	binding	NN
cord-015021-pol2qm74	3669	14	assay	assay	NN
cord-015021-pol2qm74	3669	15	.	.	.
cord-015021-pol2qm74	3670	1	Soluble	soluble	JJ
cord-015021-pol2qm74	3670	2	TNFRI	TNFRI	NNP
cord-015021-pol2qm74	3670	3	and	and	CC
cord-015021-pol2qm74	3670	4	II	II	NNP
cord-015021-pol2qm74	3670	5	could	could	MD
cord-015021-pol2qm74	3670	6	be	be	VB
cord-015021-pol2qm74	3670	7	detected	detect	VBN
cord-015021-pol2qm74	3670	8	in	in	IN
cord-015021-pol2qm74	3670	9	all	all	DT
cord-015021-pol2qm74	3670	10	samples	sample	NNS
cord-015021-pol2qm74	3670	11	with	with	IN
cord-015021-pol2qm74	3670	12	a	a	DT
cord-015021-pol2qm74	3670	13	significantly	significantly	RB
cord-015021-pol2qm74	3670	14	higher	high	JJR
cord-015021-pol2qm74	3670	15	level	level	NN
cord-015021-pol2qm74	3670	16	(	(	-LRB-
cord-015021-pol2qm74	3670	17	p	p	NN
cord-015021-pol2qm74	3670	18	<	<	XX
cord-015021-pol2qm74	3670	19	O	o	UH
cord-015021-pol2qm74	3670	20	,	,	,
cord-015021-pol2qm74	3670	21	O01	O01	NNP
cord-015021-pol2qm74	3670	22	)	)	-RRB-
cord-015021-pol2qm74	3670	23	compared	compare	VBD
cord-015021-pol2qm74	3670	24	to	to	IN
cord-015021-pol2qm74	3670	25	healthy	healthy	JJ
cord-015021-pol2qm74	3670	26	controls	control	NNS
cord-015021-pol2qm74	3670	27	(	(	-LRB-
cord-015021-pol2qm74	3670	28	normal	normal	JJ
cord-015021-pol2qm74	3670	29	value	value	NN
cord-015021-pol2qm74	3670	30	:	:	:
cord-015021-pol2qm74	3670	31	TNFRh	TNFRh	NNP
cord-015021-pol2qm74	3670	32	1,5	1,5	CD
cord-015021-pol2qm74	3670	33	ng	ng	NN
cord-015021-pol2qm74	3670	34	/	/	SYM
cord-015021-pol2qm74	3670	35	ml	ml	XX
cord-015021-pol2qm74	3670	36	;	;	:
cord-015021-pol2qm74	3670	37	TNFRII	TNFRII	NNP
cord-015021-pol2qm74	3670	38	:	:	:
cord-015021-pol2qm74	3670	39	2,3	2,3	CD
cord-015021-pol2qm74	3670	40	ng	ng	NNP
cord-015021-pol2qm74	3670	41	/	/	SYM
cord-015021-pol2qm74	3670	42	ml	ml	NN
cord-015021-pol2qm74	3670	43	)	)	-RRB-
cord-015021-pol2qm74	3670	44	.	.	.
cord-015021-pol2qm74	3671	1	The	the	DT
cord-015021-pol2qm74	3671	2	serum	serum	NN
cord-015021-pol2qm74	3671	3	concentration	concentration	NN
cord-015021-pol2qm74	3671	4	of	of	IN
cord-015021-pol2qm74	3671	5	TNFRI	TNFRI	NNP
cord-015021-pol2qm74	3672	1	(	(	-LRB-
cord-015021-pol2qm74	3672	2	14,1	14,1	CD
cord-015021-pol2qm74	3672	3	ng	ng	NNP
cord-015021-pol2qm74	3672	4	/	/	SYM
cord-015021-pol2qm74	3672	5	ml	ml	NNP
cord-015021-pol2qm74	3672	6	)	)	-RRB-
cord-015021-pol2qm74	3672	7	as	as	RB
cord-015021-pol2qm74	3672	8	well	well	RB
cord-015021-pol2qm74	3672	9	as	as	IN
cord-015021-pol2qm74	3672	10	TNFRII	TNFRII	NNP
cord-015021-pol2qm74	3672	11	(	(	-LRB-
cord-015021-pol2qm74	3672	12	18,2	18,2	CD
cord-015021-pol2qm74	3672	13	ng	ng	NNP
cord-015021-pol2qm74	3672	14	/	/	SYM
cord-015021-pol2qm74	3672	15	ml	ml	NN
cord-015021-pol2qm74	3672	16	)	)	-RRB-
cord-015021-pol2qm74	3672	17	were	be	VBD
cord-015021-pol2qm74	3672	18	significantly	significantly	RB
cord-015021-pol2qm74	3672	19	higher	high	JJR
cord-015021-pol2qm74	3672	20	in	in	IN
cord-015021-pol2qm74	3672	21	nonsurvivors	nonsurvivors	NNP
cord-015021-pol2qm74	3672	22	(	(	-LRB-
cord-015021-pol2qm74	3672	23	n=6	n=6	NNP
cord-015021-pol2qm74	3672	24	)	)	-RRB-
cord-015021-pol2qm74	3672	25	compared	compare	VBN
cord-015021-pol2qm74	3672	26	to	to	IN
cord-015021-pol2qm74	3672	27	survivors	survivor	NNS
cord-015021-pol2qm74	3672	28	(	(	-LRB-
cord-015021-pol2qm74	3672	29	8,6	8,6	CD
cord-015021-pol2qm74	3672	30	and	and	CC
cord-015021-pol2qm74	3672	31	9,5	9,5	CD
cord-015021-pol2qm74	3672	32	ng	ng	NN
cord-015021-pol2qm74	3672	33	/	/	SYM
cord-015021-pol2qm74	3672	34	ml	ml	NN
cord-015021-pol2qm74	3672	35	;	;	:
cord-015021-pol2qm74	3672	36	n=8	n=8	NN
cord-015021-pol2qm74	3672	37	)	)	-RRB-
cord-015021-pol2qm74	3672	38	at	at	IN
cord-015021-pol2qm74	3672	39	the	the	DT
cord-015021-pol2qm74	3672	40	onset	onset	NN
cord-015021-pol2qm74	3672	41	of	of	IN
cord-015021-pol2qm74	3672	42	SIRS	SIRS	NNP
cord-015021-pol2qm74	3672	43	and	and	CC
cord-015021-pol2qm74	3672	44	during	during	IN
cord-015021-pol2qm74	3672	45	the	the	DT
cord-015021-pol2qm74	3672	46	course	course	NN
cord-015021-pol2qm74	3672	47	of	of	IN
cord-015021-pol2qm74	3672	48	the	the	DT
cord-015021-pol2qm74	3672	49	inflammation	inflammation	NN
cord-015021-pol2qm74	3672	50	response	response	NN
cord-015021-pol2qm74	3672	51	(	(	-LRB-
cord-015021-pol2qm74	3672	52	p<0,05	p<0,05	NNP
cord-015021-pol2qm74	3672	53	)	)	-RRB-
cord-015021-pol2qm74	3672	54	.	.	.
cord-015021-pol2qm74	3673	1	A	a	DT
cord-015021-pol2qm74	3673	2	positive	positive	JJ
cord-015021-pol2qm74	3673	3	correlation	correlation	NN
cord-015021-pol2qm74	3673	4	exists	exist	VBZ
cord-015021-pol2qm74	3673	5	between	between	IN
cord-015021-pol2qm74	3673	6	both	both	DT
cord-015021-pol2qm74	3673	7	receptors	receptor	NNS
cord-015021-pol2qm74	3673	8	(	(	-LRB-
cord-015021-pol2qm74	3674	1	r-0,57	r-0,57	NNP
cord-015021-pol2qm74	3674	2	;	;	:
cord-015021-pol2qm74	3674	3	p	p	NN
cord-015021-pol2qm74	3674	4	<	<	XX
cord-015021-pol2qm74	3674	5	0,01	0,01	NN
cord-015021-pol2qm74	3674	6	)	)	-RRB-
cord-015021-pol2qm74	3674	7	.	.	.
cord-015021-pol2qm74	3675	1	Increasing	increase	VBG
cord-015021-pol2qm74	3675	2	levels	level	NNS
cord-015021-pol2qm74	3675	3	and	and	CC
cord-015021-pol2qm74	3675	4	maximal	maximal	JJ
cord-015021-pol2qm74	3675	5	values	value	NNS
cord-015021-pol2qm74	3675	6	of	of	IN
cord-015021-pol2qm74	3675	7	sTNFRI	stnfri	JJ
cord-015021-pol2qm74	3675	8	(	(	-LRB-
cord-015021-pol2qm74	3675	9	59	59	CD
cord-015021-pol2qm74	3675	10	ng	ng	NNP
cord-015021-pol2qm74	3675	11	/	/	SYM
cord-015021-pol2qm74	3675	12	ml	ml	NN
cord-015021-pol2qm74	3675	13	)	)	-RRB-
cord-015021-pol2qm74	3675	14	and	and	CC
cord-015021-pol2qm74	3675	15	I1	i1	NN
cord-015021-pol2qm74	3675	16	(	(	-LRB-
cord-015021-pol2qm74	3675	17	82	82	CD
cord-015021-pol2qm74	3675	18	ng	ng	NNP
cord-015021-pol2qm74	3675	19	/	/	SYM
cord-015021-pol2qm74	3675	20	mI	mI	NNP
cord-015021-pol2qm74	3675	21	)	)	-RRB-
cord-015021-pol2qm74	3675	22	were	be	VBD
cord-015021-pol2qm74	3675	23	detected	detect	VBN
cord-015021-pol2qm74	3675	24	only	only	RB
cord-015021-pol2qm74	3675	25	in	in	IN
cord-015021-pol2qm74	3675	26	patients	patient	NNS
cord-015021-pol2qm74	3675	27	who	who	WP
cord-015021-pol2qm74	3675	28	died	die	VBD
cord-015021-pol2qm74	3675	29	.	.	.
cord-015021-pol2qm74	3676	1	The	the	DT
cord-015021-pol2qm74	3676	2	serum	serum	NN
cord-015021-pol2qm74	3676	3	concentrations	concentration	NNS
cord-015021-pol2qm74	3676	4	of	of	IN
cord-015021-pol2qm74	3676	5	patients	patient	NNS
cord-015021-pol2qm74	3676	6	who	who	WP
cord-015021-pol2qm74	3676	7	recovered	recover	VBD
cord-015021-pol2qm74	3676	8	did	do	VBD
cord-015021-pol2qm74	3676	9	not	not	RB
cord-015021-pol2qm74	3676	10	change	change	VB
cord-015021-pol2qm74	3676	11	and	and	CC
cord-015021-pol2qm74	3676	12	are	be	VBP
cord-015021-pol2qm74	3676	13	remaining	remain	VBG
cord-015021-pol2qm74	3676	14	at	at	IN
cord-015021-pol2qm74	3676	15	the	the	DT
cord-015021-pol2qm74	3676	16	initial	initial	JJ
cord-015021-pol2qm74	3676	17	level	level	NN
cord-015021-pol2qm74	3676	18	.	.	.
cord-015021-pol2qm74	3677	1	TNF	TNF	NNP
cord-015021-pol2qm74	3677	2	alpha	alpha	NN
cord-015021-pol2qm74	3677	3	bioactivity	bioactivity	NN
cord-015021-pol2qm74	3677	4	was	be	VBD
cord-015021-pol2qm74	3677	5	detected	detect	VBN
cord-015021-pol2qm74	3677	6	in	in	IN
cord-015021-pol2qm74	3677	7	10	10	CD
cord-015021-pol2qm74	3677	8	out	out	IN
cord-015021-pol2qm74	3677	9	of	of	IN
cord-015021-pol2qm74	3677	10	14	14	CD
cord-015021-pol2qm74	3677	11	patients	patient	NNS
cord-015021-pol2qm74	3677	12	.	.	.
cord-015021-pol2qm74	3678	1	No	no	DT
cord-015021-pol2qm74	3678	2	significant	significant	JJ
cord-015021-pol2qm74	3678	3	correlation	correlation	NN
cord-015021-pol2qm74	3678	4	exists	exist	VBZ
cord-015021-pol2qm74	3678	5	between	between	IN
cord-015021-pol2qm74	3678	6	the	the	DT
cord-015021-pol2qm74	3678	7	concentration	concentration	NN
cord-015021-pol2qm74	3678	8	of	of	IN
cord-015021-pol2qm74	3678	9	both	both	DT
cord-015021-pol2qm74	3678	10	receptors	receptor	NNS
cord-015021-pol2qm74	3678	11	and	and	CC
cord-015021-pol2qm74	3678	12	TNF	TNF	NNP
cord-015021-pol2qm74	3678	13	alpha	alpha	NN
cord-015021-pol2qm74	3678	14	as	as	RB
cord-015021-pol2qm74	3678	15	well	well	RB
cord-015021-pol2qm74	3678	16	as	as	IN
cord-015021-pol2qm74	3678	17	the	the	DT
cord-015021-pol2qm74	3678	18	APACHE	APACHE	NNP
cord-015021-pol2qm74	3678	19	II	II	NNP
cord-015021-pol2qm74	3678	20	score	score	NN
cord-015021-pol2qm74	3678	21	at	at	IN
cord-015021-pol2qm74	3678	22	the	the	DT
cord-015021-pol2qm74	3678	23	onset	onset	NN
cord-015021-pol2qm74	3678	24	of	of	IN
cord-015021-pol2qm74	3678	25	SIRS	SIRS	NNP
cord-015021-pol2qm74	3678	26	.	.	.
cord-015021-pol2qm74	3679	1	Elevated	elevated	JJ
cord-015021-pol2qm74	3679	2	serum	serum	NN
cord-015021-pol2qm74	3679	3	concentration	concentration	NN
cord-015021-pol2qm74	3679	4	of	of	IN
cord-015021-pol2qm74	3679	5	sTNFRI	stnfri	JJ
cord-015021-pol2qm74	3679	6	and	and	CC
cord-015021-pol2qm74	3679	7	11	11	CD
cord-015021-pol2qm74	3679	8	are	be	VBP
cord-015021-pol2qm74	3679	9	found	find	VBN
cord-015021-pol2qm74	3679	10	in	in	IN
cord-015021-pol2qm74	3679	11	patients	patient	NNS
cord-015021-pol2qm74	3679	12	with	with	IN
cord-015021-pol2qm74	3679	13	SIRS	SIRS	NNP
cord-015021-pol2qm74	3679	14	.	.	.
cord-015021-pol2qm74	3680	1	These	these	DT
cord-015021-pol2qm74	3680	2	naturally	naturally	RB
cord-015021-pol2qm74	3680	3	occuring	occur	VBG
cord-015021-pol2qm74	3680	4	antagonists	antagonist	NNS
cord-015021-pol2qm74	3680	5	reflect	reflect	VBP
cord-015021-pol2qm74	3680	6	the	the	DT
cord-015021-pol2qm74	3680	7	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3680	8	process	process	NN
cord-015021-pol2qm74	3680	9	.	.	.
cord-015021-pol2qm74	3681	1	The	the	DT
cord-015021-pol2qm74	3681	2	measurement	measurement	NN
cord-015021-pol2qm74	3681	3	of	of	IN
cord-015021-pol2qm74	3681	4	soluble	soluble	JJ
cord-015021-pol2qm74	3681	5	TNF	TNF	NNP
cord-015021-pol2qm74	3681	6	receptor	receptor	NN
cord-015021-pol2qm74	3681	7	levels	level	NNS
cord-015021-pol2qm74	3681	8	may	may	MD
cord-015021-pol2qm74	3681	9	be	be	VB
cord-015021-pol2qm74	3681	10	useful	useful	JJ
cord-015021-pol2qm74	3681	11	in	in	IN
cord-015021-pol2qm74	3681	12	monitorina	monitorina	JJ
cord-015021-pol2qm74	3681	13	SIRS	SIRS	NNP
cord-015021-pol2qm74	3681	14	and	and	CC
cord-015021-pol2qm74	3681	15	in	in	IN
cord-015021-pol2qm74	3681	16	the	the	DT
cord-015021-pol2qm74	3681	17	prediction	prediction	NN
cord-015021-pol2qm74	3681	18	of	of	IN
cord-015021-pol2qm74	3681	19	outcome	outcome	NN
cord-015021-pol2qm74	3681	20	.	.	.
cord-015021-pol2qm74	3682	1	11	11	CD
cord-015021-pol2qm74	3682	2	-	-	SYM
cord-015021-pol2qm74	3682	3	2	2	CD
cord-015021-pol2qm74	3682	4	is	be	VBZ
cord-015021-pol2qm74	3682	5	given	give	VBN
cord-015021-pol2qm74	3682	6	to	to	IN
cord-015021-pol2qm74	3682	7	patients	patient	NNS
cord-015021-pol2qm74	3682	8	with	with	IN
cord-015021-pol2qm74	3682	9	advanced	advanced	JJ
cord-015021-pol2qm74	3682	10	melanoma	melanoma	NN
cord-015021-pol2qm74	3682	11	or	or	CC
cord-015021-pol2qm74	3682	12	renal	renal	JJ
cord-015021-pol2qm74	3682	13	carcinoma	carcinoma	NN
cord-015021-pol2qm74	3682	14	.	.	.
cord-015021-pol2qm74	3683	1	However	however	RB
cord-015021-pol2qm74	3683	2	,	,	,
cord-015021-pol2qm74	3683	3	this	this	DT
cord-015021-pol2qm74	3683	4	therapy	therapy	NN
cord-015021-pol2qm74	3683	5	is	be	VBZ
cord-015021-pol2qm74	3683	6	accompanied	accompany	VBN
cord-015021-pol2qm74	3683	7	by	by	IN
cord-015021-pol2qm74	3683	8	severe	severe	JJ
cord-015021-pol2qm74	3683	9	side	side	NN
cord-015021-pol2qm74	3683	10	effects	effect	NNS
cord-015021-pol2qm74	3683	11	,	,	,
cord-015021-pol2qm74	3683	12	including	include	VBG
cord-015021-pol2qm74	3683	13	the	the	DT
cord-015021-pol2qm74	3683	14	Vascular	vascular	JJ
cord-015021-pol2qm74	3683	15	Leak	Leak	NNP
cord-015021-pol2qm74	3683	16	Syndrome	syndrome	NN
cord-015021-pol2qm74	3683	17	(	(	-LRB-
cord-015021-pol2qm74	3683	18	VLS	VLS	NNP
cord-015021-pol2qm74	3683	19	)	)	-RRB-
cord-015021-pol2qm74	3683	20	that	that	WDT
cord-015021-pol2qm74	3683	21	closely	closely	RB
cord-015021-pol2qm74	3683	22	resembles	resemble	VBZ
cord-015021-pol2qm74	3683	23	septic	septic	JJ
cord-015021-pol2qm74	3683	24	shock	shock	NN
cord-015021-pol2qm74	3683	25	.	.	.
cord-015021-pol2qm74	3684	1	To	to	TO
cord-015021-pol2qm74	3684	2	investigate	investigate	VB
cord-015021-pol2qm74	3684	3	the	the	DT
cord-015021-pol2qm74	3684	4	involvement	involvement	NN
cord-015021-pol2qm74	3684	5	of	of	IN
cord-015021-pol2qm74	3684	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	3684	7	and	and	CC
cord-015021-pol2qm74	3684	8	phospholipase	phospholipase	NN
cord-015021-pol2qm74	3684	9	A	a	DT
cord-015021-pol2qm74	3684	10	z	z	NN
cord-015021-pol2qm74	3684	11	in	in	IN
cord-015021-pol2qm74	3684	12	the	the	DT
cord-015021-pol2qm74	3684	13	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	3684	14	of	of	IN
cord-015021-pol2qm74	3684	15	the	the	DT
cord-015021-pol2qm74	3684	16	VLS	vls	NN
cord-015021-pol2qm74	3684	17	we	-PRON-	PRP
cord-015021-pol2qm74	3684	18	collected	collect	VBD
cord-015021-pol2qm74	3684	19	serial	serial	JJ
cord-015021-pol2qm74	3684	20	plasma	plasma	NN
cord-015021-pol2qm74	3684	21	samples	sample	NNS
cord-015021-pol2qm74	3684	22	from	from	IN
cord-015021-pol2qm74	3684	23	patients	patient	NNS
cord-015021-pol2qm74	3684	24	during	during	IN
cord-015021-pol2qm74	3684	25	the	the	DT
cord-015021-pol2qm74	3684	26	first	first	JJ
cord-015021-pol2qm74	3684	27	24	24	CD
cord-015021-pol2qm74	3684	28	hours	hour	NNS
cord-015021-pol2qm74	3684	29	after	after	IN
cord-015021-pol2qm74	3684	30	administration	administration	NN
cord-015021-pol2qm74	3684	31	of	of	IN
cord-015021-pol2qm74	3684	32	IL-2	IL-2	NNP
cord-015021-pol2qm74	3684	33	.	.	.
cord-015021-pol2qm74	3685	1	In	in	IN
cord-015021-pol2qm74	3685	2	these	these	DT
cord-015021-pol2qm74	3685	3	patients	patient	NNS
cord-015021-pol2qm74	3685	4	we	-PRON-	PRP
cord-015021-pol2qm74	3685	5	monitored	monitor	VBD
cord-015021-pol2qm74	3685	6	temperature	temperature	NN
cord-015021-pol2qm74	3685	7	,	,	,
cord-015021-pol2qm74	3685	8	blood	blood	NN
cord-015021-pol2qm74	3685	9	pressure	pressure	NN
cord-015021-pol2qm74	3685	10	and	and	CC
cord-015021-pol2qm74	3685	11	heart	heart	NN
cord-015021-pol2qm74	3685	12	rate	rate	NN
cord-015021-pol2qm74	3685	13	and	and	CC
cord-015021-pol2qm74	3685	14	assessed	assess	VBN
cord-015021-pol2qm74	3685	15	levels	level	NNS
cord-015021-pol2qm74	3685	16	of	of	IN
cord-015021-pol2qm74	3685	17	the	the	DT
cord-015021-pol2qm74	3685	18	cytokines	cytokine	NNS
cord-015021-pol2qm74	3685	19	TNF	TNF	NNP
cord-015021-pol2qm74	3685	20	,	,	,
cord-015021-pol2qm74	3685	21	IL-6	IL-6	NNP
cord-015021-pol2qm74	3685	22	and	and	CC
cord-015021-pol2qm74	3685	23	IL-8	IL-8	NNP
cord-015021-pol2qm74	3685	24	using	use	VBG
cord-015021-pol2qm74	3685	25	immuno	immuno	JJ
cord-015021-pol2qm74	3685	26	assays	assay	NNS
cord-015021-pol2qm74	3685	27	.	.	.
cord-015021-pol2qm74	3686	1	In	in	IN
cord-015021-pol2qm74	3686	2	these	these	DT
cord-015021-pol2qm74	3686	3	plasma	plasma	NN
cord-015021-pol2qm74	3686	4	samples	sample	NNS
cord-015021-pol2qm74	3686	5	we	-PRON-	PRP
cord-015021-pol2qm74	3686	6	also	also	RB
cord-015021-pol2qm74	3686	7	measured	measure	VBD
cord-015021-pol2qm74	3686	8	phospholipase	phospholipase	NN
cord-015021-pol2qm74	3687	1	A	a	DT
cord-015021-pol2qm74	3687	2	2	2	CD
cord-015021-pol2qm74	3687	3	activity	activity	NN
cord-015021-pol2qm74	3687	4	using	use	VBG
cord-015021-pol2qm74	3687	5	an	an	DT
cord-015021-pol2qm74	3687	6	enzyme	enzyme	NN
cord-015021-pol2qm74	3687	7	activity	activity	NN
cord-015021-pol2qm74	3687	8	assay	assay	NN
cord-015021-pol2qm74	3687	9	,	,	,
cord-015021-pol2qm74	3687	10	since	since	IN
cord-015021-pol2qm74	3687	11	this	this	DT
cord-015021-pol2qm74	3687	12	enzyme	enzyme	NN
cord-015021-pol2qm74	3687	13	is	be	VBZ
cord-015021-pol2qm74	3687	14	beleived	beleive	VBN
cord-015021-pol2qm74	3687	15	to	to	TO
cord-015021-pol2qm74	3687	16	play	play	VB
cord-015021-pol2qm74	3687	17	a	a	DT
cord-015021-pol2qm74	3687	18	major	major	JJ
cord-015021-pol2qm74	3687	19	role	role	NN
cord-015021-pol2qm74	3687	20	in	in	IN
cord-015021-pol2qm74	3687	21	the	the	DT
cord-015021-pol2qm74	3687	22	generation	generation	NN
cord-015021-pol2qm74	3687	23	of	of	IN
cord-015021-pol2qm74	3687	24	lipid	lipid	NN
cord-015021-pol2qm74	3687	25	mediators	mediator	NNS
cord-015021-pol2qm74	3687	26	.	.	.
cord-015021-pol2qm74	3688	1	We	-PRON-	PRP
cord-015021-pol2qm74	3688	2	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	3688	3	that	that	IN
cord-015021-pol2qm74	3688	4	during	during	IN
cord-015021-pol2qm74	3688	5	IL-2	IL-2	NNP
cord-015021-pol2qm74	3688	6	therapy	therapy	NN
cord-015021-pol2qm74	3688	7	the	the	DT
cord-015021-pol2qm74	3688	8	cytokines	cytokine	NNS
cord-015021-pol2qm74	3688	9	TNF	TNF	NNP
cord-015021-pol2qm74	3688	10	,	,	,
cord-015021-pol2qm74	3688	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	3688	12	,	,	,
cord-015021-pol2qm74	3688	13	and	and	CC
cord-015021-pol2qm74	3688	14	IL-8	IL-8	NNP
cord-015021-pol2qm74	3688	15	are	be	VBP
cord-015021-pol2qm74	3688	16	produced	produce	VBN
cord-015021-pol2qm74	3688	17	and	and	CC
cord-015021-pol2qm74	3688	18	that	that	IN
cord-015021-pol2qm74	3688	19	the	the	DT
cord-015021-pol2qm74	3688	20	release	release	NN
cord-015021-pol2qm74	3688	21	of	of	IN
cord-015021-pol2qm74	3688	22	these	these	DT
cord-015021-pol2qm74	3688	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	3688	24	is	be	VBZ
cord-015021-pol2qm74	3688	25	followed	follow	VBN
cord-015021-pol2qm74	3688	26	by	by	IN
cord-015021-pol2qm74	3688	27	an	an	DT
cord-015021-pol2qm74	3688	28	induction	induction	NN
cord-015021-pol2qm74	3688	29	of	of	IN
cord-015021-pol2qm74	3688	30	phospholipase	phospholipase	NN
cord-015021-pol2qm74	3688	31	Az	Az	NNP
cord-015021-pol2qm74	3688	32	activity	activity	NN
cord-015021-pol2qm74	3688	33	in	in	IN
cord-015021-pol2qm74	3688	34	the	the	DT
cord-015021-pol2qm74	3688	35	plasma	plasma	NN
cord-015021-pol2qm74	3688	36	of	of	IN
cord-015021-pol2qm74	3688	37	these	these	DT
cord-015021-pol2qm74	3688	38	patients	patient	NNS
cord-015021-pol2qm74	3688	39	,	,	,
cord-015021-pol2qm74	3688	40	We	-PRON-	PRP
cord-015021-pol2qm74	3688	41	further	further	RB
cord-015021-pol2qm74	3688	42	discuss	discuss	VBP
cord-015021-pol2qm74	3688	43	the	the	DT
cord-015021-pol2qm74	3688	44	role	role	NN
cord-015021-pol2qm74	3688	45	of	of	IN
cord-015021-pol2qm74	3688	46	these	these	DT
cord-015021-pol2qm74	3688	47	mediators	mediator	NNS
cord-015021-pol2qm74	3688	48	in	in	IN
cord-015021-pol2qm74	3688	49	the	the	DT
cord-015021-pol2qm74	3688	50	development	development	NN
cord-015021-pol2qm74	3688	51	of	of	IN
cord-015021-pol2qm74	3688	52	the	the	DT
cord-015021-pol2qm74	3688	53	vascular	vascular	JJ
cord-015021-pol2qm74	3688	54	leak	leak	NN
cord-015021-pol2qm74	3688	55	syndrome	syndrome	NN
cord-015021-pol2qm74	3688	56	observed	observe	VBN
cord-015021-pol2qm74	3688	57	in	in	IN
cord-015021-pol2qm74	3688	58	patients	patient	NNS
cord-015021-pol2qm74	3688	59	receiving	receive	VBG
cord-015021-pol2qm74	3688	60	IL-2	IL-2	NNP
cord-015021-pol2qm74	3688	61	.	.	.
cord-015021-pol2qm74	3689	1	Objectives	objective	NNS
cord-015021-pol2qm74	3689	2	of	of	IN
cord-015021-pol2qm74	3689	3	the	the	DT
cord-015021-pol2qm74	3689	4	study	study	NN
cord-015021-pol2qm74	3689	5	:	:	:
cord-015021-pol2qm74	3689	6	Sepsis	sepsis	NN
cord-015021-pol2qm74	3689	7	caused	cause	VBN
cord-015021-pol2qm74	3689	8	by	by	IN
cord-015021-pol2qm74	3689	9	Candida	Candida	NNP
cord-015021-pol2qm74	3689	10	albicans	albican	NNS
cord-015021-pol2qm74	3689	11	(	(	-LRB-
cord-015021-pol2qm74	3689	12	CA	CA	NNP
cord-015021-pol2qm74	3689	13	)	)	-RRB-
cord-015021-pol2qm74	3689	14	is	be	VBZ
cord-015021-pol2qm74	3689	15	no	no	RB
cord-015021-pol2qm74	3689	16	longer	long	RBR
cord-015021-pol2qm74	3689	17	a	a	DT
cord-015021-pol2qm74	3689	18	clinical	clinical	JJ
cord-015021-pol2qm74	3689	19	rarity	rarity	NN
cord-015021-pol2qm74	3689	20	but	but	CC
cord-015021-pol2qm74	3689	21	a	a	DT
cord-015021-pol2qm74	3689	22	common	common	JJ
cord-015021-pol2qm74	3689	23	consequence	consequence	NN
cord-015021-pol2qm74	3689	24	of	of	IN
cord-015021-pol2qm74	3689	25	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	3689	26	and	and	CC
cord-015021-pol2qm74	3689	27	surgery	surgery	NN
cord-015021-pol2qm74	3689	28	,	,	,
cord-015021-pol2qm74	3689	29	and	and	CC
cord-015021-pol2qm74	3689	30	is	be	VBZ
cord-015021-pol2qm74	3689	31	associated	associate	VBN
cord-015021-pol2qm74	3689	32	with	with	IN
cord-015021-pol2qm74	3689	33	high	high	JJ
cord-015021-pol2qm74	3689	34	mortality	mortality	NN
cord-015021-pol2qm74	3689	35	.	.	.
cord-015021-pol2qm74	3690	1	Tumor	tumor	NN
cord-015021-pol2qm74	3690	2	necrosis	necrosis	NN
cord-015021-pol2qm74	3690	3	faetor	faetor	NN
cord-015021-pol2qm74	3690	4	-	-	HYPH
cord-015021-pol2qm74	3690	5	c¢	c¢	NNP
cord-015021-pol2qm74	3690	6	(	(	-LRB-
cord-015021-pol2qm74	3690	7	TNF-<~	tnf-<~	NN
cord-015021-pol2qm74	3690	8	)	)	-RRB-
cord-015021-pol2qm74	3691	1	,	,	,
cord-015021-pol2qm74	3691	2	interlcukin	interlcukin	NNP
cord-015021-pol2qm74	3691	3	-	-	HYPH
cord-015021-pol2qm74	3691	4	lg	lg	NNP
cord-015021-pol2qm74	3691	5	(	(	-LRB-
cord-015021-pol2qm74	3691	6	IL	IL	NNP
cord-015021-pol2qm74	3691	7	-	-	HYPH
cord-015021-pol2qm74	3691	8	lg	lg	NNP
cord-015021-pol2qm74	3691	9	)	)	-RRB-
cord-015021-pol2qm74	3691	10	and	and	CC
cord-015021-pol2qm74	3691	11	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	3691	12	(	(	-LRB-
cord-015021-pol2qm74	3691	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	3691	14	)	)	-RRB-
cord-015021-pol2qm74	3691	15	are	be	VBP
cord-015021-pol2qm74	3691	16	thought	think	VBN
cord-015021-pol2qm74	3691	17	to	to	TO
cord-015021-pol2qm74	3691	18	play	play	VB
cord-015021-pol2qm74	3691	19	an	an	DT
cord-015021-pol2qm74	3691	20	important	important	JJ
cord-015021-pol2qm74	3691	21	role	role	NN
cord-015021-pol2qm74	3691	22	in	in	IN
cord-015021-pol2qm74	3691	23	the	the	DT
cord-015021-pol2qm74	3691	24	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	3691	25	of	of	IN
cord-015021-pol2qm74	3691	26	the	the	DT
cord-015021-pol2qm74	3691	27	sepsis	sepsis	NN
cord-015021-pol2qm74	3691	28	syndrome	syndrome	NN
cord-015021-pol2qm74	3691	29	.	.	.
cord-015021-pol2qm74	3692	1	We	-PRON-	PRP
cord-015021-pol2qm74	3692	2	therefore	therefore	RB
cord-015021-pol2qm74	3692	3	studied	study	VBD
cord-015021-pol2qm74	3692	4	the	the	DT
cord-015021-pol2qm74	3692	5	in	in	FW
cord-015021-pol2qm74	3692	6	vitro	vitro	FW
cord-015021-pol2qm74	3692	7	production	production	NN
cord-015021-pol2qm74	3692	8	of	of	IN
cord-015021-pol2qm74	3692	9	TNF-<x	TNF-<x	NNP
cord-015021-pol2qm74	3692	10	,	,	,
cord-015021-pol2qm74	3692	11	IL	IL	NNP
cord-015021-pol2qm74	3692	12	-	-	HYPH
cord-015021-pol2qm74	3692	13	IB	IB	NNP
cord-015021-pol2qm74	3692	14	and	and	CC
cord-015021-pol2qm74	3692	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	3692	16	by	by	IN
cord-015021-pol2qm74	3692	17	human	human	JJ
cord-015021-pol2qm74	3692	18	peripheral	peripheral	JJ
cord-015021-pol2qm74	3692	19	blood	blood	NN
cord-015021-pol2qm74	3692	20	mononuclear	mononuclear	NN
cord-015021-pol2qm74	3692	21	cells	cell	NNS
cord-015021-pol2qm74	3692	22	(	(	-LRB-
cord-015021-pol2qm74	3692	23	PBMC	PBMC	NNP
cord-015021-pol2qm74	3692	24	)	)	-RRB-
cord-015021-pol2qm74	3692	25	stimulated	stimulate	VBN
cord-015021-pol2qm74	3692	26	by	by	IN
cord-015021-pol2qm74	3692	27	CA	CA	NNP
cord-015021-pol2qm74	3692	28	compared	compare	VBD
cord-015021-pol2qm74	3692	29	to	to	IN
cord-015021-pol2qm74	3692	30	stimulation	stimulation	NN
cord-015021-pol2qm74	3692	31	by	by	IN
cord-015021-pol2qm74	3692	32	bacterial	bacterial	JJ
cord-015021-pol2qm74	3692	33	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3692	34	(	(	-LRB-
cord-015021-pol2qm74	3692	35	LPS	LPS	NNP
cord-015021-pol2qm74	3692	36	)	)	-RRB-
cord-015021-pol2qm74	3692	37	.	.	.
cord-015021-pol2qm74	3693	1	Materials	material	NNS
cord-015021-pol2qm74	3693	2	and	and	CC
cord-015021-pol2qm74	3693	3	methods	method	NNS
cord-015021-pol2qm74	3693	4	:	:	:
cord-015021-pol2qm74	3693	5	PBMC	PBMC	NNS
cord-015021-pol2qm74	3693	6	were	be	VBD
cord-015021-pol2qm74	3693	7	isolated	isolate	VBN
cord-015021-pol2qm74	3693	8	from	from	IN
cord-015021-pol2qm74	3693	9	venous	venous	JJ
cord-015021-pol2qm74	3693	10	blood	blood	NN
cord-015021-pol2qm74	3693	11	of	of	IN
cord-015021-pol2qm74	3693	12	5	5	CD
cord-015021-pol2qm74	3693	13	healthy	healthy	JJ
cord-015021-pol2qm74	3693	14	volunteers	volunteer	NNS
cord-015021-pol2qm74	3693	15	and	and	CC
cord-015021-pol2qm74	3693	16	cultured	culture	VBN
cord-015021-pol2qm74	3693	17	at	at	IN
cord-015021-pol2qm74	3693	18	a	a	DT
cord-015021-pol2qm74	3693	19	concentration	concentration	NN
cord-015021-pol2qm74	3693	20	of	of	IN
cord-015021-pol2qm74	3693	21	2.5	2.5	CD
cord-015021-pol2qm74	3693	22	•	•	NNS
cord-015021-pol2qm74	3693	23	10	10	CD
cord-015021-pol2qm74	3694	1	~	~	NFP
cord-015021-pol2qm74	3694	2	eells	eells	NNP
cord-015021-pol2qm74	3694	3	/	/	SYM
cord-015021-pol2qm74	3694	4	ml	ml	XX
cord-015021-pol2qm74	3694	5	in	in	IN
cord-015021-pol2qm74	3694	6	culture	culture	NN
cord-015021-pol2qm74	3694	7	medium	medium	NN
cord-015021-pol2qm74	3694	8	with	with	IN
cord-015021-pol2qm74	3694	9	a	a	DT
cord-015021-pol2qm74	3694	10	dose	dose	NN
cord-015021-pol2qm74	3694	11	-	-	HYPH
cord-015021-pol2qm74	3694	12	range	range	NN
cord-015021-pol2qm74	3694	13	of	of	IN
cord-015021-pol2qm74	3694	14	either	either	DT
cord-015021-pol2qm74	3694	15	heat	heat	NN
cord-015021-pol2qm74	3694	16	-	-	HYPH
cord-015021-pol2qm74	3694	17	killed	kill	VBN
cord-015021-pol2qm74	3694	18	CA	CA	NNP
cord-015021-pol2qm74	3694	19	or	or	CC
cord-015021-pol2qm74	3694	20	LPS	LPS	NNP
cord-015021-pol2qm74	3694	21	.	.	.
cord-015021-pol2qm74	3695	1	Supernatants	supernatant	NNS
cord-015021-pol2qm74	3695	2	were	be	VBD
cord-015021-pol2qm74	3695	3	harvested	harvest	VBN
cord-015021-pol2qm74	3695	4	after	after	IN
cord-015021-pol2qm74	3695	5	24	24	CD
cord-015021-pol2qm74	3695	6	hours	hour	NNS
cord-015021-pol2qm74	3695	7	.	.	.
cord-015021-pol2qm74	3696	1	Using	use	VBG
cord-015021-pol2qm74	3696	2	ELISA	ELISA	NNP
cord-015021-pol2qm74	3696	3	,	,	,
cord-015021-pol2qm74	3696	4	TNF	TNF	NNP
cord-015021-pol2qm74	3696	5	-	-	HYPH
cord-015021-pol2qm74	3696	6	c~	c~	NNP
cord-015021-pol2qm74	3696	7	,	,	,
cord-015021-pol2qm74	3696	8	IL	IL	NNP
cord-015021-pol2qm74	3696	9	-	-	HYPH
cord-015021-pol2qm74	3696	10	IB	IB	NNP
cord-015021-pol2qm74	3696	11	and	and	CC
cord-015021-pol2qm74	3696	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	3696	13	concentrations	concentration	NNS
cord-015021-pol2qm74	3696	14	were	be	VBD
cord-015021-pol2qm74	3696	15	measured	measure	VBN
cord-015021-pol2qm74	3696	16	.	.	.
cord-015021-pol2qm74	3697	1	CA	CA	NNP
cord-015021-pol2qm74	3697	2	was	be	VBD
cord-015021-pol2qm74	3697	3	isolated	isolate	VBN
cord-015021-pol2qm74	3697	4	from	from	IN
cord-015021-pol2qm74	3697	5	a	a	DT
cord-015021-pol2qm74	3697	6	patient	patient	NN
cord-015021-pol2qm74	3697	7	with	with	IN
cord-015021-pol2qm74	3697	8	CA	CA	NNP
cord-015021-pol2qm74	3697	9	sepsis	sepsis	NN
cord-015021-pol2qm74	3697	10	and	and	CC
cord-015021-pol2qm74	3697	11	cultured	culture	VBN
cord-015021-pol2qm74	3697	12	under	under	IN
cord-015021-pol2qm74	3697	13	sterile	sterile	JJ
cord-015021-pol2qm74	3697	14	conditions	condition	NNS
cord-015021-pol2qm74	3697	15	.	.	.
cord-015021-pol2qm74	3698	1	Results	result	NNS
cord-015021-pol2qm74	3698	2	:	:	:
cord-015021-pol2qm74	3699	1	CA	CA	NNP
cord-015021-pol2qm74	3699	2	and	and	CC
cord-015021-pol2qm74	3699	3	LPS	LPS	NNP
cord-015021-pol2qm74	3699	4	stimulate	stimulate	VBP
cord-015021-pol2qm74	3699	5	the	the	DT
cord-015021-pol2qm74	3699	6	production	production	NN
cord-015021-pol2qm74	3699	7	of	of	IN
cord-015021-pol2qm74	3699	8	TNF-~t	tnf-~t	NN
cord-015021-pol2qm74	3699	9	,	,	,
cord-015021-pol2qm74	3699	10	IL-11	IL-11	NNP
cord-015021-pol2qm74	3699	11	]	]	-RRB-
cord-015021-pol2qm74	3699	12	and	and	CC
cord-015021-pol2qm74	3699	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	3699	14	by	by	IN
cord-015021-pol2qm74	3699	15	human	human	JJ
cord-015021-pol2qm74	3699	16	PBMC	PBMC	NNS
cord-015021-pol2qm74	3699	17	.	.	.
cord-015021-pol2qm74	3700	1	We	-PRON-	PRP
cord-015021-pol2qm74	3700	2	observed	observe	VBD
cord-015021-pol2qm74	3700	3	a	a	DT
cord-015021-pol2qm74	3700	4	dose	dose	NN
cord-015021-pol2qm74	3700	5	-	-	HYPH
cord-015021-pol2qm74	3700	6	dependent	dependent	JJ
cord-015021-pol2qm74	3700	7	synthesis	synthesis	NN
cord-015021-pol2qm74	3700	8	of	of	IN
cord-015021-pol2qm74	3700	9	these	these	DT
cord-015021-pol2qm74	3700	10	three	three	CD
cord-015021-pol2qm74	3700	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	3700	12	in	in	IN
cord-015021-pol2qm74	3700	13	human	human	JJ
cord-015021-pol2qm74	3700	14	PBMC	PBMC	NNS
cord-015021-pol2qm74	3700	15	.	.	.
cord-015021-pol2qm74	3701	1	TNF	TNF	NNP
cord-015021-pol2qm74	3701	2	-	-	HYPH
cord-015021-pol2qm74	3701	3	c¢	c¢	NNP
cord-015021-pol2qm74	3701	4	,	,	,
cord-015021-pol2qm74	3701	5	IL	IL	NNP
cord-015021-pol2qm74	3701	6	-	-	HYPH
cord-015021-pol2qm74	3701	7	IB	IB	NNP
cord-015021-pol2qm74	3701	8	and	and	CC
cord-015021-pol2qm74	3702	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	3702	2	in	in	IN
cord-015021-pol2qm74	3702	3	ng	ng	NNP
cord-015021-pol2qm74	3702	4	/	/	SYM
cord-015021-pol2qm74	3702	5	ml	ml	NN
cord-015021-pol2qm74	3703	1	as	as	IN
cord-015021-pol2qm74	3703	2	mean	mean	JJ
cord-015021-pol2qm74	3704	1	_	_	NNP
cord-015021-pol2qm74	3704	2	+	+	CC
cord-015021-pol2qm74	3704	3	standard	standard	JJ
cord-015021-pol2qm74	3704	4	error	error	NN
cord-015021-pol2qm74	3704	5	.	.	.
cord-015021-pol2qm74	3705	1	CA	CA	NNP
cord-015021-pol2qm74	3705	2	/	/	SYM
cord-015021-pol2qm74	3705	3	ml	ml	NN
cord-015021-pol2qm74	3705	4	0.0	0.0	CD
cord-015021-pol2qm74	3705	5	1	1	CD
cord-015021-pol2qm74	3705	6	.	.	.
cord-015021-pol2qm74	3706	1	(	(	-LRB-
cord-015021-pol2qm74	3706	2	2	2	LS
cord-015021-pol2qm74	3706	3	)	)	-RRB-
cord-015021-pol2qm74	3706	4	We	-PRON-	PRP
cord-015021-pol2qm74	3706	5	constructed	construct	VBD
cord-015021-pol2qm74	3706	6	a	a	DT
cord-015021-pol2qm74	3706	7	single	single	JJ
cord-015021-pol2qm74	3706	8	-	-	HYPH
cord-015021-pol2qm74	3706	9	chain	chain	NN
cord-015021-pol2qm74	3706	10	Fv	fv	NN
cord-015021-pol2qm74	3706	11	-	-	HYPH
cord-015021-pol2qm74	3706	12	fragment	fragment	NN
cord-015021-pol2qm74	3706	13	(	(	-LRB-
cord-015021-pol2qm74	3706	14	sc	sc	NNP
cord-015021-pol2qm74	3706	15	-	-	HYPH
cord-015021-pol2qm74	3706	16	Fv	Fv	NNP
cord-015021-pol2qm74	3706	17	)	)	-RRB-
cord-015021-pol2qm74	3706	18	from	from	IN
cord-015021-pol2qm74	3706	19	the	the	DT
cord-015021-pol2qm74	3706	20	variable	variable	JJ
cord-015021-pol2qm74	3706	21	domains	domain	NNS
cord-015021-pol2qm74	3706	22	of	of	IN
cord-015021-pol2qm74	3706	23	a	a	DT
cord-015021-pol2qm74	3706	24	neutralizing	neutralize	VBG
cord-015021-pol2qm74	3706	25	antibody	antibody	NN
cord-015021-pol2qm74	3706	26	to	to	IN
cord-015021-pol2qm74	3706	27	human	human	JJ
cord-015021-pol2qm74	3706	28	tumornecrosisfactor	tumornecrosisfactor	NN
cord-015021-pol2qm74	3706	29	-	-	HYPH
cord-015021-pol2qm74	3706	30	alpha	alpha	NN
cord-015021-pol2qm74	3706	31	(	(	-LRB-
cord-015021-pol2qm74	3706	32	TNF	TNF	NNP
cord-015021-pol2qm74	3706	33	)	)	-RRB-
cord-015021-pol2qm74	3706	34	because	because	IN
cord-015021-pol2qm74	3706	35	sc	sc	NNP
cord-015021-pol2qm74	3706	36	-	-	HYPH
cord-015021-pol2qm74	3706	37	Fv	Fv	NNP
cord-015021-pol2qm74	3706	38	should	should	MD
cord-015021-pol2qm74	3706	39	have	have	VB
cord-015021-pol2qm74	3706	40	some	some	DT
cord-015021-pol2qm74	3706	41	advantages	advantage	NNS
cord-015021-pol2qm74	3706	42	in	in	IN
cord-015021-pol2qm74	3706	43	vivo	vivo	NN
cord-015021-pol2qm74	3706	44	.	.	.
cord-015021-pol2qm74	3707	1	The	the	DT
cord-015021-pol2qm74	3707	2	sc	sc	JJ
cord-015021-pol2qm74	3707	3	-	-	HYPH
cord-015021-pol2qm74	3707	4	Fv	Fv	NNP
cord-015021-pol2qm74	3707	5	has	have	VBZ
cord-015021-pol2qm74	3707	6	a	a	DT
cord-015021-pol2qm74	3707	7	similar	similar	JJ
cord-015021-pol2qm74	3707	8	affinity	affinity	NN
cord-015021-pol2qm74	3707	9	(	(	-LRB-
cord-015021-pol2qm74	3707	10	3,8x10	3,8x10	NNP
cord-015021-pol2qm74	3707	11	-	-	SYM
cord-015021-pol2qm74	3707	12	9	9	CD
cord-015021-pol2qm74	3707	13	M	M	NNP
cord-015021-pol2qm74	3707	14	)	)	-RRB-
cord-015021-pol2qm74	3707	15	as	as	IN
cord-015021-pol2qm74	3707	16	the	the	DT
cord-015021-pol2qm74	3707	17	Fab	Fab	NNP
cord-015021-pol2qm74	3707	18	-	-	HYPH
cord-015021-pol2qm74	3707	19	fragment	fragment	NN
cord-015021-pol2qm74	3707	20	(	(	-LRB-
cord-015021-pol2qm74	3707	21	2,7x10	2,7x10	NNP
cord-015021-pol2qm74	3707	22	-	-	SYM
cord-015021-pol2qm74	3707	23	9	9	CD
cord-015021-pol2qm74	3707	24	M	M	NNP
cord-015021-pol2qm74	3707	25	)	)	-RRB-
cord-015021-pol2qm74	3707	26	but	but	CC
cord-015021-pol2qm74	3707	27	bind	bind	VB
cord-015021-pol2qm74	3707	28	the	the	DT
cord-015021-pol2qm74	3707	29	antigen	antigen	NN
cord-015021-pol2qm74	3707	30	with	with	IN
cord-015021-pol2qm74	3707	31	a	a	DT
cord-015021-pol2qm74	3707	32	eightfold	eightfold	JJ
cord-015021-pol2qm74	3707	33	lower	low	JJR
cord-015021-pol2qm74	3707	34	avidity	avidity	NN
cord-015021-pol2qm74	3707	35	compared	compare	VBN
cord-015021-pol2qm74	3707	36	to	to	IN
cord-015021-pol2qm74	3707	37	the	the	DT
cord-015021-pol2qm74	3707	38	parental	parental	JJ
cord-015021-pol2qm74	3707	39	mAb	mAb	NNS
cord-015021-pol2qm74	3707	40	(	(	-LRB-
cord-015021-pol2qm74	3707	41	4,8x10	4,8x10	CD
cord-015021-pol2qm74	3707	42	-	-	SYM
cord-015021-pol2qm74	3707	43	10	10	CD
cord-015021-pol2qm74	3707	44	)	)	-RRB-
cord-015021-pol2qm74	3707	45	.	.	.
cord-015021-pol2qm74	3708	1	The	the	DT
cord-015021-pol2qm74	3708	2	parental	parental	JJ
cord-015021-pol2qm74	3708	3	mAb	mab	NN
cord-015021-pol2qm74	3708	4	as	as	RB
cord-015021-pol2qm74	3708	5	well	well	RB
cord-015021-pol2qm74	3708	6	as	as	IN
cord-015021-pol2qm74	3708	7	its	-PRON-	PRP$
cord-015021-pol2qm74	3708	8	fragments	fragment	NNS
cord-015021-pol2qm74	3708	9	can	can	MD
cord-015021-pol2qm74	3708	10	compete	compete	VB
cord-015021-pol2qm74	3708	11	the	the	DT
cord-015021-pol2qm74	3708	12	binding	binding	NN
cord-015021-pol2qm74	3708	13	of	of	IN
cord-015021-pol2qm74	3708	14	rhuTNF	rhutnf	NN
cord-015021-pol2qm74	3708	15	to	to	IN
cord-015021-pol2qm74	3708	16	both	both	CC
cord-015021-pol2qm74	3708	17	TNF	TNF	NNP
cord-015021-pol2qm74	3708	18	-	-	HYPH
cord-015021-pol2qm74	3708	19	receptors	receptor	NNS
cord-015021-pol2qm74	3708	20	.	.	.
cord-015021-pol2qm74	3709	1	This	this	DT
cord-015021-pol2qm74	3709	2	was	be	VBD
cord-015021-pol2qm74	3709	3	shown	show	VBN
cord-015021-pol2qm74	3709	4	by	by	IN
cord-015021-pol2qm74	3709	5	competitive	competitive	JJ
cord-015021-pol2qm74	3709	6	binding	binding	NN
cord-015021-pol2qm74	3709	7	to	to	IN
cord-015021-pol2qm74	3709	8	the	the	DT
cord-015021-pol2qm74	3709	9	cell	cell	NN
cord-015021-pol2qm74	3709	10	line	line	NN
cord-015021-pol2qm74	3709	11	HL-60	HL-60	NNP
cord-015021-pol2qm74	3709	12	and	and	CC
cord-015021-pol2qm74	3709	13	to	to	IN
cord-015021-pol2qm74	3709	14	immobilized	immobilized	JJ
cord-015021-pol2qm74	3709	15	rTNF	rtnf	NN
cord-015021-pol2qm74	3709	16	-	-	HYPH
cord-015021-pol2qm74	3709	17	receptors	receptor	NNS
cord-015021-pol2qm74	3709	18	.	.	.
cord-015021-pol2qm74	3710	1	In	in	IN
cord-015021-pol2qm74	3710	2	the	the	DT
cord-015021-pol2qm74	3710	3	nutralization	nutralization	NN
cord-015021-pol2qm74	3710	4	assay	assay	NN
cord-015021-pol2qm74	3710	5	on	on	IN
cord-015021-pol2qm74	3710	6	the	the	DT
cord-015021-pol2qm74	3710	7	cell	cell	NN
cord-015021-pol2qm74	3710	8	line	line	NN
cord-015021-pol2qm74	3710	9	,	,	,
cord-015021-pol2qm74	3710	10	L	L	NNP
cord-015021-pol2qm74	3710	11	929	929	CD
cord-015021-pol2qm74	3710	12	,	,	,
cord-015021-pol2qm74	3710	13	the	the	DT
cord-015021-pol2qm74	3710	14	sc	sc	NNP
cord-015021-pol2qm74	3710	15	-	-	HYPH
cord-015021-pol2qm74	3710	16	Fv	Fv	NNP
cord-015021-pol2qm74	3710	17	can	can	MD
cord-015021-pol2qm74	3710	18	neutralize	neutralize	VB
cord-015021-pol2qm74	3710	19	TNF	TNF	NNP
cord-015021-pol2qm74	3710	20	but	but	CC
cord-015021-pol2qm74	3710	21	in	in	IN
cord-015021-pol2qm74	3710	22	comparison	comparison	NN
cord-015021-pol2qm74	3710	23	to	to	IN
cord-015021-pol2qm74	3710	24	the	the	DT
cord-015021-pol2qm74	3710	25	mAb	mAb	NNS
cord-015021-pol2qm74	3710	26	or	or	CC
cord-015021-pol2qm74	3710	27	its	-PRON-	PRP$
cord-015021-pol2qm74	3710	28	Fabfragment	Fabfragment	NNP
cord-015021-pol2qm74	3710	29	,	,	,
cord-015021-pol2qm74	3710	30	the	the	DT
cord-015021-pol2qm74	3710	31	capacity	capacity	NN
cord-015021-pol2qm74	3710	32	was	be	VBD
cord-015021-pol2qm74	3710	33	three	three	CD
cord-015021-pol2qm74	3710	34	-	-	HYPH
cord-015021-pol2qm74	3710	35	fold	fold	RB
cord-015021-pol2qm74	3710	36	lower	lower	RBR
cord-015021-pol2qm74	3710	37	as	as	IN
cord-015021-pol2qm74	3710	38	expected	expect	VBN
cord-015021-pol2qm74	3710	39	from	from	IN
cord-015021-pol2qm74	3710	40	the	the	DT
cord-015021-pol2qm74	3710	41	molar	molar	JJ
cord-015021-pol2qm74	3710	42	ratio	ratio	NN
cord-015021-pol2qm74	3710	43	of	of	IN
cord-015021-pol2qm74	3710	44	the	the	DT
cord-015021-pol2qm74	3710	45	dissociation	dissociation	NN
cord-015021-pol2qm74	3710	46	constants	constant	NNS
cord-015021-pol2qm74	3710	47	.	.	.
cord-015021-pol2qm74	3711	1	The	the	DT
cord-015021-pol2qm74	3711	2	in	in	IN
cord-015021-pol2qm74	3711	3	rive	rive	NN
cord-015021-pol2qm74	3711	4	-	-	HYPH
cord-015021-pol2qm74	3711	5	neutralizing	neutralize	VBG
cord-015021-pol2qm74	3711	6	capacity	capacity	NN
cord-015021-pol2qm74	3711	7	was	be	VBD
cord-015021-pol2qm74	3711	8	tested	test	VBN
cord-015021-pol2qm74	3711	9	in	in	IN
cord-015021-pol2qm74	3711	10	a	a	DT
cord-015021-pol2qm74	3711	11	mice	mice	NN
cord-015021-pol2qm74	3711	12	receiving	receive	VBG
cord-015021-pol2qm74	3711	13	toxic	toxic	JJ
cord-015021-pol2qm74	3711	14	dose	dose	NN
cord-015021-pol2qm74	3711	15	of	of	IN
cord-015021-pol2qm74	3711	16	rhuTNF	rhutnf	NN
cord-015021-pol2qm74	3711	17	.	.	.
cord-015021-pol2qm74	3712	1	The	the	DT
cord-015021-pol2qm74	3712	2	sc	sc	NNP
cord-015021-pol2qm74	3712	3	-	-	HYPH
cord-015021-pol2qm74	3712	4	Fv	Fv	NNP
cord-015021-pol2qm74	3712	5	showed	show	VBD
cord-015021-pol2qm74	3712	6	a	a	DT
cord-015021-pol2qm74	3712	7	15-fold	15-fold	RB
cord-015021-pol2qm74	3712	8	lower	low	JJR
cord-015021-pol2qm74	3712	9	neutralizing	neutralize	VBG
cord-015021-pol2qm74	3712	10	capacity	capacity	NN
cord-015021-pol2qm74	3712	11	in	in	IN
cord-015021-pol2qm74	3712	12	comparison	comparison	NN
cord-015021-pol2qm74	3712	13	with	with	IN
cord-015021-pol2qm74	3712	14	the	the	DT
cord-015021-pol2qm74	3712	15	Fab	fab	JJ
cord-015021-pol2qm74	3712	16	-	-	HYPH
cord-015021-pol2qm74	3712	17	fragment	fragment	NN
cord-015021-pol2qm74	3712	18	.	.	.
cord-015021-pol2qm74	3713	1	This	this	DT
cord-015021-pol2qm74	3713	2	could	could	MD
cord-015021-pol2qm74	3713	3	be	be	VB
cord-015021-pol2qm74	3713	4	explained	explain	VBN
cord-015021-pol2qm74	3713	5	in	in	IN
cord-015021-pol2qm74	3713	6	different	different	JJ
cord-015021-pol2qm74	3713	7	manners	manner	NNS
cord-015021-pol2qm74	3713	8	:	:	:
cord-015021-pol2qm74	3713	9	i	i	LS
cord-015021-pol2qm74	3713	10	)	)	-RRB-
cord-015021-pol2qm74	3713	11	partial	partial	JJ
cord-015021-pol2qm74	3713	12	instability	instability	NN
cord-015021-pol2qm74	3713	13	of	of	IN
cord-015021-pol2qm74	3713	14	scFv	scFv	NNP
cord-015021-pol2qm74	3713	15	at	at	IN
cord-015021-pol2qm74	3713	16	370C	370C	NNP
cord-015021-pol2qm74	3713	17	,	,	,
cord-015021-pol2qm74	3713	18	ii	ii	LS
cord-015021-pol2qm74	3713	19	)	)	-RRB-
cord-015021-pol2qm74	3713	20	shorter	short	JJR
cord-015021-pol2qm74	3713	21	half	half	JJ
cord-015021-pol2qm74	3713	22	-	-	HYPH
cord-015021-pol2qm74	3713	23	life	life	NN
cord-015021-pol2qm74	3713	24	because	because	IN
cord-015021-pol2qm74	3713	25	sc	sc	NNP
cord-015021-pol2qm74	3713	26	-	-	HYPH
cord-015021-pol2qm74	3713	27	Fv	Fv	NNP
cord-015021-pol2qm74	3713	28	but	but	CC
cord-015021-pol2qm74	3713	29	not	not	RB
cord-015021-pol2qm74	3713	30	Fab	fab	JJ
cord-015021-pol2qm74	3713	31	-	-	HYPH
cord-015021-pol2qm74	3713	32	fragments	fragment	NNS
cord-015021-pol2qm74	3713	33	are	be	VBP
cord-015021-pol2qm74	3713	34	eliminated	eliminate	VBN
cord-015021-pol2qm74	3713	35	via	via	IN
cord-015021-pol2qm74	3713	36	kidney	kidney	NN
cord-015021-pol2qm74	3713	37	,	,	,
cord-015021-pol2qm74	3713	38	iii	iii	LS
cord-015021-pol2qm74	3713	39	)	)	-RRB-
cord-015021-pol2qm74	3713	40	elimination	elimination	NN
cord-015021-pol2qm74	3713	41	of	of	IN
cord-015021-pol2qm74	3713	42	TNF	TNF	NNP
cord-015021-pol2qm74	3713	43	-	-	HYPH
cord-015021-pol2qm74	3713	44	immunocomplexes	immunocomplexes	NNP
cord-015021-pol2qm74	3713	45	may	may	MD
cord-015021-pol2qm74	3713	46	be	be	VB
cord-015021-pol2qm74	3713	47	improved	improve	VBN
cord-015021-pol2qm74	3713	48	by	by	IN
cord-015021-pol2qm74	3713	49	opsonization	opsonization	NN
cord-015021-pol2qm74	3713	50	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3713	51	which	which	WDT
cord-015021-pol2qm74	3713	52	requires	require	VBZ
cord-015021-pol2qm74	3713	53	some	some	DT
cord-015021-pol2qm74	3713	54	structures	structure	NNS
cord-015021-pol2qm74	3713	55	of	of	IN
cord-015021-pol2qm74	3713	56	the	the	DT
cord-015021-pol2qm74	3713	57	constant	constant	JJ
cord-015021-pol2qm74	3713	58	region	region	NN
cord-015021-pol2qm74	3713	59	(	(	-LRB-
cord-015021-pol2qm74	3713	60	as	as	IN
cord-015021-pol2qm74	3713	61	in	in	IN
cord-015021-pol2qm74	3713	62	Fab	Fab	NNP
cord-015021-pol2qm74	3713	63	or	or	CC
cord-015021-pol2qm74	3713	64	mAb	mAb	NNS
cord-015021-pol2qm74	3713	65	)	)	-RRB-
cord-015021-pol2qm74	3713	66	.	.	.
cord-015021-pol2qm74	3714	1	In	in	IN
cord-015021-pol2qm74	3714	2	summary	summary	NN
cord-015021-pol2qm74	3714	3	,	,	,
cord-015021-pol2qm74	3714	4	despite	despite	IN
cord-015021-pol2qm74	3714	5	the	the	DT
cord-015021-pol2qm74	3714	6	encouraging	encouraging	NN
cord-015021-pol2qm74	3714	7	in	in	IN
cord-015021-pol2qm74	3714	8	vitro	vitro	FW
cord-015021-pol2qm74	3714	9	experiments	experiment	NNS
cord-015021-pol2qm74	3714	10	,	,	,
cord-015021-pol2qm74	3714	11	the	the	DT
cord-015021-pol2qm74	3714	12	in	in	IN
cord-015021-pol2qm74	3714	13	vivo	vivo	NNP
cord-015021-pol2qm74	3714	14	data	datum	NNS
cord-015021-pol2qm74	3714	15	suggest	suggest	VBP
cord-015021-pol2qm74	3714	16	that	that	IN
cord-015021-pol2qm74	3714	17	sc	sc	NNP
cord-015021-pol2qm74	3714	18	-	-	HYPH
cord-015021-pol2qm74	3714	19	Fv	Fv	NNP
cord-015021-pol2qm74	3714	20	are	be	VBP
cord-015021-pol2qm74	3714	21	not	not	RB
cord-015021-pol2qm74	3714	22	the	the	DT
cord-015021-pol2qm74	3714	23	right	right	JJ
cord-015021-pol2qm74	3714	24	strategy	strategy	NN
cord-015021-pol2qm74	3714	25	for	for	IN
cord-015021-pol2qm74	3714	26	neutralizing	neutralize	VBG
cord-015021-pol2qm74	3714	27	TNF	TNF	NNP
cord-015021-pol2qm74	3714	28	in	in	IN
cord-015021-pol2qm74	3714	29	vivo	vivo	NNP
cord-015021-pol2qm74	3714	30	.	.	.
cord-015021-pol2qm74	3715	1	TNF	tnf	NN
cord-015021-pol2qm74	3715	2	PRODUCTION	production	NN
cord-015021-pol2qm74	3715	3	IN	in	IN
cord-015021-pol2qm74	3715	4	ENDOTOXIN	endotoxin	NN
cord-015021-pol2qm74	3715	5	NON	NON	NNP
cord-015021-pol2qm74	3715	6	-	-	NNP
cord-015021-pol2qm74	3715	7	RESPONDER	responder	JJ
cord-015021-pol2qm74	3715	8	MICE	mouse	NNS
cord-015021-pol2qm74	3715	9	,	,	,
cord-015021-pol2qm74	3715	10	EFFECT	effect	NN
cord-015021-pol2qm74	3715	11	OF	of	IN
cord-015021-pol2qm74	3715	12	A	a	DT
cord-015021-pol2qm74	3715	13	GLUCOCORTICOID	GLUCOCORTICOID	NNP
cord-015021-pol2qm74	3715	14	ANTAGONIST	antagonist	NN
cord-015021-pol2qm74	3715	15	G.	G.	NNP
cord-015021-pol2qm74	3715	16	IAzgtr	IAzgtr	NNP
cord-015021-pol2qm74	3715	17	Jr	Jr	NNP
cord-015021-pol2qm74	3715	18	,	,	,
cord-015021-pol2qm74	3715	19	E.	E.	NNP
cord-015021-pol2qm74	3715	20	Duda	Duda	NNP
cord-015021-pol2qm74	3715	21	,	,	,
cord-015021-pol2qm74	3715	22	J.	J.	NNP
cord-015021-pol2qm74	3715	23	Ol	Ol	NNP
cord-015021-pol2qm74	3715	24	~	~	NFP
cord-015021-pol2qm74	3715	25	th	th	XX
cord-015021-pol2qm74	3715	26	,	,	,
cord-015021-pol2qm74	3715	27	E.	E.	NNP
cord-015021-pol2qm74	3715	28	Husztik	Husztik	NNP
cord-015021-pol2qm74	3715	29	,	,	,
cord-015021-pol2qm74	3715	30	G.	G.	NNP
cord-015021-pol2qm74	3715	31	IAzAr	iazar	XX
cord-015021-pol2qm74	3716	1	Glucocorticoids	Glucocorticoids	NNP
cord-015021-pol2qm74	3716	2	inhibit	inhibit	VBP
cord-015021-pol2qm74	3716	3	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3716	4	(	(	-LRB-
cord-015021-pol2qm74	3717	1	LPS)-induced	LPS)-induced	NNP
cord-015021-pol2qm74	3717	2	TNF	TNF	NNP
cord-015021-pol2qm74	3717	3	production	production	NN
cord-015021-pol2qm74	3717	4	and	and	CC
cord-015021-pol2qm74	3717	5	TNF	TNF	NNP
cord-015021-pol2qm74	3717	6	can	can	MD
cord-015021-pol2qm74	3717	7	stimulate	stimulate	VB
cord-015021-pol2qm74	3717	8	pituitary	pituitary	JJ
cord-015021-pol2qm74	3717	9	adrenocorticotropin	adrenocorticotropin	JJ
cord-015021-pol2qm74	3717	10	secretion	secretion	NN
cord-015021-pol2qm74	3717	11	,	,	,
cord-015021-pol2qm74	3717	12	resulting	result	VBG
cord-015021-pol2qm74	3717	13	in	in	IN
cord-015021-pol2qm74	3717	14	the	the	DT
cord-015021-pol2qm74	3717	15	release	release	NN
cord-015021-pol2qm74	3717	16	of	of	IN
cord-015021-pol2qm74	3717	17	corticosterone	corticosterone	NN
cord-015021-pol2qm74	3717	18	.	.	.
cord-015021-pol2qm74	3718	1	Earlier	early	JJR
cord-015021-pol2qm74	3718	2	studies	study	NNS
cord-015021-pol2qm74	3718	3	(	(	-LRB-
cord-015021-pol2qm74	3718	4	1	1	LS
cord-015021-pol2qm74	3718	5	)	)	-RRB-
cord-015021-pol2qm74	3718	6	reveales	reveale	NNS
cord-015021-pol2qm74	3718	7	that	that	IN
cord-015021-pol2qm74	3718	8	the	the	DT
cord-015021-pol2qm74	3718	9	glucocorticoid	glucocorticoid	NN
cord-015021-pol2qm74	3718	10	antagonist	antagonist	NN
cord-015021-pol2qm74	3718	11	RU	RU	NNP
cord-015021-pol2qm74	3718	12	38486	38486	CD
cord-015021-pol2qm74	3718	13	,	,	,
cord-015021-pol2qm74	3718	14	nufepristone	nufepristone	NN
cord-015021-pol2qm74	3718	15	,	,	,
cord-015021-pol2qm74	3718	16	sensitizes	sensitize	VBZ
cord-015021-pol2qm74	3718	17	both	both	DT
cord-015021-pol2qm74	3718	18	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3718	19	responder	responder	NN
cord-015021-pol2qm74	3718	20	and	and	CC
cord-015021-pol2qm74	3718	21	nonresponder	nonresponder	NNP
cord-015021-pol2qm74	3718	22	,	,	,
cord-015021-pol2qm74	3718	23	C3H	C3H	NNP
cord-015021-pol2qm74	3718	24	/	/	SYM
cord-015021-pol2qm74	3718	25	HeJ	HeJ	NNP
cord-015021-pol2qm74	3718	26	,	,	,
cord-015021-pol2qm74	3718	27	mice	mouse	NNS
cord-015021-pol2qm74	3718	28	to	to	TO
cord-015021-pol2qm74	3718	29	endotoxin	endotoxin	VB
cord-015021-pol2qm74	3718	30	lethality	lethality	NN
cord-015021-pol2qm74	3718	31	.	.	.
cord-015021-pol2qm74	3719	1	We	-PRON-	PRP
cord-015021-pol2qm74	3719	2	have	have	VBP
cord-015021-pol2qm74	3719	3	also	also	RB
cord-015021-pol2qm74	3719	4	shown	show	VBN
cord-015021-pol2qm74	3719	5	that	that	IN
cord-015021-pol2qm74	3719	6	the	the	DT
cord-015021-pol2qm74	3719	7	glucocorticoid	glucocorticoid	NN
cord-015021-pol2qm74	3719	8	antagonist	antagonist	NN
cord-015021-pol2qm74	3719	9	RU	RU	NNP
cord-015021-pol2qm74	3719	10	38486	38486	CD
cord-015021-pol2qm74	3719	11	sensitizes	sensitize	VBZ
cord-015021-pol2qm74	3719	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3719	13	-	-	HYPH
cord-015021-pol2qm74	3719	14	tolerant	tolerant	JJ
cord-015021-pol2qm74	3719	15	(	(	-LRB-
cord-015021-pol2qm74	3719	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3719	17	-	-	HYPH
cord-015021-pol2qm74	3719	18	pretreated	pretreate	VBN
cord-015021-pol2qm74	3719	19	)	)	-RRB-
cord-015021-pol2qm74	3719	20	and	and	CC
cord-015021-pol2qm74	3719	21	normal	normal	JJ
cord-015021-pol2qm74	3719	22	mice	mouse	NNS
cord-015021-pol2qm74	3719	23	to	to	IN
cord-015021-pol2qm74	3719	24	the	the	DT
cord-015021-pol2qm74	3719	25	lethal	lethal	JJ
cord-015021-pol2qm74	3719	26	effect	effect	NN
cord-015021-pol2qm74	3719	27	of	of	IN
cord-015021-pol2qm74	3719	28	septic	septic	NN
cord-015021-pol2qm74	3719	29	and	and	CC
cord-015021-pol2qm74	3719	30	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3719	31	shock	shock	NN
cord-015021-pol2qm74	3719	32	.	.	.
cord-015021-pol2qm74	3720	1	On	on	IN
cord-015021-pol2qm74	3720	2	this	this	DT
cord-015021-pol2qm74	3720	3	basis	basis	NN
cord-015021-pol2qm74	3720	4	,	,	,
cord-015021-pol2qm74	3720	5	we	-PRON-	PRP
cord-015021-pol2qm74	3720	6	set	set	VBD
cord-015021-pol2qm74	3720	7	out	out	RP
cord-015021-pol2qm74	3720	8	to	to	TO
cord-015021-pol2qm74	3720	9	study	study	VB
cord-015021-pol2qm74	3720	10	the	the	DT
cord-015021-pol2qm74	3720	11	influence	influence	NN
cord-015021-pol2qm74	3720	12	of	of	IN
cord-015021-pol2qm74	3720	13	RU	RU	NNP
cord-015021-pol2qm74	3720	14	38486	38486	CD
cord-015021-pol2qm74	3720	15	on	on	IN
cord-015021-pol2qm74	3720	16	TNF	TNF	NNP
cord-015021-pol2qm74	3720	17	production	production	NN
cord-015021-pol2qm74	3720	18	induced	induce	VBN
cord-015021-pol2qm74	3720	19	by	by	IN
cord-015021-pol2qm74	3720	20	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3720	21	in	in	IN
cord-015021-pol2qm74	3720	22	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3720	23	responder	responder	NN
cord-015021-pol2qm74	3720	24	and	and	CC
cord-015021-pol2qm74	3720	25	non	non	JJ
cord-015021-pol2qm74	3720	26	-	-	JJ
cord-015021-pol2qm74	3720	27	responder	responder	JJ
cord-015021-pol2qm74	3720	28	mice	mouse	NNS
cord-015021-pol2qm74	3720	29	.	.	.
cord-015021-pol2qm74	3721	1	One	one	CD
cord-015021-pol2qm74	3721	2	and	and	CC
cord-015021-pol2qm74	3721	3	2	2	CD
cord-015021-pol2qm74	3721	4	hrs	hrs	NN
cord-015021-pol2qm74	3721	5	following	follow	VBG
cord-015021-pol2qm74	3721	6	LPS	LPS	NNP
cord-015021-pol2qm74	3721	7	injection	injection	NN
cord-015021-pol2qm74	3721	8	,	,	,
cord-015021-pol2qm74	3721	9	RU	RU	NNP
cord-015021-pol2qm74	3721	10	38486	38486	CD
cord-015021-pol2qm74	3721	11	significantly	significantly	RB
cord-015021-pol2qm74	3721	12	increased	increase	VBD
cord-015021-pol2qm74	3721	13	the	the	DT
cord-015021-pol2qm74	3721	14	TNF	TNF	NNP
cord-015021-pol2qm74	3721	15	concentration	concentration	NN
cord-015021-pol2qm74	3721	16	in	in	IN
cord-015021-pol2qm74	3721	17	the	the	DT
cord-015021-pol2qm74	3721	18	serum	serum	NN
cord-015021-pol2qm74	3721	19	,	,	,
cord-015021-pol2qm74	3721	20	liver	liver	NN
cord-015021-pol2qm74	3721	21	and	and	CC
cord-015021-pol2qm74	3721	22	spleen	spleen	NN
cord-015021-pol2qm74	3721	23	of	of	IN
cord-015021-pol2qm74	3721	24	treated	treat	VBN
cord-015021-pol2qm74	3721	25	animals	animal	NNS
cord-015021-pol2qm74	3721	26	as	as	IN
cord-015021-pol2qm74	3721	27	compared	compare	VBN
cord-015021-pol2qm74	3721	28	with	with	IN
cord-015021-pol2qm74	3721	29	the	the	DT
cord-015021-pol2qm74	3721	30	control	control	NN
cord-015021-pol2qm74	3721	31	and	and	CC
cord-015021-pol2qm74	3721	32	methylprednisolonetreated	methylprednisolonetreated	JJ
cord-015021-pol2qm74	3721	33	groups	group	NNS
cord-015021-pol2qm74	3721	34	.	.	.
cord-015021-pol2qm74	3722	1	In	in	IN
cord-015021-pol2qm74	3722	2	tissue	tissue	NN
cord-015021-pol2qm74	3722	3	cultures	culture	NNS
cord-015021-pol2qm74	3722	4	,	,	,
cord-015021-pol2qm74	3722	5	RU	RU	NNP
cord-015021-pol2qm74	3722	6	38486	38486	CD
cord-015021-pol2qm74	3722	7	induced	induce	VBD
cord-015021-pol2qm74	3722	8	the	the	DT
cord-015021-pol2qm74	3722	9	TNF	TNF	NNP
cord-015021-pol2qm74	3722	10	synthesis	synthesis	NN
cord-015021-pol2qm74	3722	11	of	of	IN
cord-015021-pol2qm74	3722	12	myeloid	myeloid	NN
cord-015021-pol2qm74	3722	13	cells	cell	NNS
cord-015021-pol2qm74	3722	14	and	and	CC
cord-015021-pol2qm74	3722	15	increased	increase	VBD
cord-015021-pol2qm74	3722	16	the	the	DT
cord-015021-pol2qm74	3722	17	TNF	TNF	NNP
cord-015021-pol2qm74	3722	18	production	production	NN
cord-015021-pol2qm74	3722	19	of	of	IN
cord-015021-pol2qm74	3722	20	genetically	genetically	RB
cord-015021-pol2qm74	3722	21	modified	modify	VBN
cord-015021-pol2qm74	3722	22	HeLa	HeLa	NNP
cord-015021-pol2qm74	3722	23	cells	cell	NNS
cord-015021-pol2qm74	3722	24	,	,	,
cord-015021-pol2qm74	3722	25	which	which	WDT
cord-015021-pol2qm74	3722	26	synthesize	synthesize	VBP
cord-015021-pol2qm74	3722	27	TNF	TNF	NNP
cord-015021-pol2qm74	3722	28	constitutively	constitutively	RB
cord-015021-pol2qm74	3722	29	.	.	.
cord-015021-pol2qm74	3723	1	Normal	normal	JJ
cord-015021-pol2qm74	3723	2	and	and	CC
cord-015021-pol2qm74	3723	3	tumor	tumor	NN
cord-015021-pol2qm74	3723	4	cell	cell	NN
cord-015021-pol2qm74	3723	5	cultures	culture	NNS
cord-015021-pol2qm74	3723	6	exhibited	exhibit	VBD
cord-015021-pol2qm74	3723	7	an	an	DT
cord-015021-pol2qm74	3723	8	increased	increase	VBN
cord-015021-pol2qm74	3723	9	sensitivity	sensitivity	NN
cord-015021-pol2qm74	3723	10	toward	toward	IN
cord-015021-pol2qm74	3723	11	TNF	TNF	NNP
cord-015021-pol2qm74	3723	12	in	in	IN
cord-015021-pol2qm74	3723	13	the	the	DT
cord-015021-pol2qm74	3723	14	presence	presence	NN
cord-015021-pol2qm74	3723	15	of	of	IN
cord-015021-pol2qm74	3723	16	RU	RU	NNP
cord-015021-pol2qm74	3723	17	38486	38486	CD
cord-015021-pol2qm74	3723	18	.	.	.
cord-015021-pol2qm74	3724	1	However	however	RB
cord-015021-pol2qm74	3724	2	,	,	,
cord-015021-pol2qm74	3724	3	the	the	DT
cord-015021-pol2qm74	3724	4	same	same	JJ
cord-015021-pol2qm74	3724	5	dose	dose	NN
cord-015021-pol2qm74	3724	6	of	of	IN
cord-015021-pol2qm74	3724	7	LPS	LPS	NNP
cord-015021-pol2qm74	3724	8	did	do	VBD
cord-015021-pol2qm74	3724	9	not	not	RB
cord-015021-pol2qm74	3724	10	induce	induce	VB
cord-015021-pol2qm74	3724	11	TNF	TNF	NNP
cord-015021-pol2qm74	3724	12	production	production	NN
cord-015021-pol2qm74	3724	13	in	in	IN
cord-015021-pol2qm74	3724	14	the	the	DT
cord-015021-pol2qm74	3724	15	serum	serum	NN
cord-015021-pol2qm74	3724	16	,	,	,
cord-015021-pol2qm74	3724	17	liver	liver	NN
cord-015021-pol2qm74	3724	18	and	and	CC
cord-015021-pol2qm74	3724	19	spleen	spleen	NNS
cord-015021-pol2qm74	3724	20	of	of	IN
cord-015021-pol2qm74	3724	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3724	22	non	non	JJ
cord-015021-pol2qm74	3724	23	-	-	JJ
cord-015021-pol2qm74	3724	24	responder	responder	JJ
cord-015021-pol2qm74	3724	25	mice	mouse	NNS
cord-015021-pol2qm74	3724	26	and	and	CC
cord-015021-pol2qm74	3724	27	this	this	DT
cord-015021-pol2qm74	3724	28	was	be	VBD
cord-015021-pol2qm74	3724	29	not	not	RB
cord-015021-pol2qm74	3724	30	influenced	influence	VBN
cord-015021-pol2qm74	3724	31	by	by	IN
cord-015021-pol2qm74	3724	32	concomitant	concomitant	JJ
cord-015021-pol2qm74	3724	33	RU	RU	NNP
cord-015021-pol2qm74	3724	34	38486	38486	CD
cord-015021-pol2qm74	3724	35	treatment	treatment	NN
cord-015021-pol2qm74	3724	36	.	.	.
cord-015021-pol2qm74	3725	1	These	these	DT
cord-015021-pol2qm74	3725	2	studies	study	NNS
cord-015021-pol2qm74	3725	3	suggest	suggest	VBP
cord-015021-pol2qm74	3725	4	that	that	IN
cord-015021-pol2qm74	3725	5	RU	RU	NNP
cord-015021-pol2qm74	3725	6	38486	38486	CD
cord-015021-pol2qm74	3725	7	aggravates	aggravate	VBZ
cord-015021-pol2qm74	3725	8	LPS	LPS	NNP
cord-015021-pol2qm74	3725	9	lethality	lethality	NN
cord-015021-pol2qm74	3725	10	via	via	IN
cord-015021-pol2qm74	3725	11	factors	factor	NNS
cord-015021-pol2qm74	3725	12	other	other	JJ
cord-015021-pol2qm74	3725	13	than	than	IN
cord-015021-pol2qm74	3725	14	TNF	TNF	NNP
cord-015021-pol2qm74	3725	15	in	in	IN
cord-015021-pol2qm74	3725	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3725	17	non	non	JJ
cord-015021-pol2qm74	3725	18	-	-	NN
cord-015021-pol2qm74	3725	19	responder	responder	JJ
cord-015021-pol2qm74	3725	20	,	,	,
cord-015021-pol2qm74	3725	21	C3H	c3h	JJ
cord-015021-pol2qm74	3725	22	/	/	SYM
cord-015021-pol2qm74	3725	23	HeJ	HeJ	NNP
cord-015021-pol2qm74	3725	24	mice	mouse	NNS
cord-015021-pol2qm74	3725	25	.	.	.
cord-015021-pol2qm74	3726	1	The	the	DT
cord-015021-pol2qm74	3726	2	cytokine	cytokine	NN
cord-015021-pol2qm74	3726	3	response	response	NN
cord-015021-pol2qm74	3726	4	to	to	IN
cord-015021-pol2qm74	3726	5	a	a	DT
cord-015021-pol2qm74	3726	6	novel	novel	JJ
cord-015021-pol2qm74	3726	7	exnacellular	exnacellular	JJ
cord-015021-pol2qm74	3726	8	mitogenic	mitogenic	JJ
cord-015021-pol2qm74	3726	9	factor	factor	NN
cord-015021-pol2qm74	3726	10	,	,	,
cord-015021-pol2qm74	3726	11	MF	MF	NNP
cord-015021-pol2qm74	3726	12	,	,	,
cord-015021-pol2qm74	3726	13	produced	produce	VBN
cord-015021-pol2qm74	3726	14	by	by	IN
cord-015021-pol2qm74	3726	15	the	the	DT
cord-015021-pol2qm74	3726	16	group	group	NN
cord-015021-pol2qm74	3726	17	A	a	DT
cord-015021-pol2qm74	3726	18	streptococci	streptococcus	NNS
cord-015021-pol2qm74	3726	19	(	(	-LRB-
cord-015021-pol2qm74	3726	20	GAS	gas	NN
cord-015021-pol2qm74	3726	21	)	)	-RRB-
cord-015021-pol2qm74	3726	22	,	,	,
cord-015021-pol2qm74	3726	23	and	and	CC
cord-015021-pol2qm74	3726	24	to	to	IN
cord-015021-pol2qm74	3726	25	the	the	DT
cord-015021-pol2qm74	3726	26	streptococcal	streptococcal	JJ
cord-015021-pol2qm74	3726	27	pyrogenic	pyrogenic	JJ
cord-015021-pol2qm74	3726	28	exotoxins	exotoxin	NNS
cord-015021-pol2qm74	3726	29	(	(	-LRB-
cord-015021-pol2qm74	3726	30	Spe	Spe	NNP
cord-015021-pol2qm74	3726	31	)	)	-RRB-
cord-015021-pol2qm74	3726	32	A	a	NN
cord-015021-pol2qm74	3726	33	and	and	CC
cord-015021-pol2qm74	3726	34	B	b	NN
cord-015021-pol2qm74	3726	35	,	,	,
cord-015021-pol2qm74	3726	36	was	be	VBD
cord-015021-pol2qm74	3726	37	determined	determine	VBN
cord-015021-pol2qm74	3726	38	by	by	IN
cord-015021-pol2qm74	3726	39	in	in	FW
cord-015021-pol2qm74	3726	40	vitro	vitro	FW
cord-015021-pol2qm74	3726	41	stimulation	stimulation	NN
cord-015021-pol2qm74	3726	42	of	of	IN
cord-015021-pol2qm74	3726	43	peripheral	peripheral	JJ
cord-015021-pol2qm74	3726	44	blood	blood	NN
cord-015021-pol2qm74	3726	45	mononuclear	mononuclear	NN
cord-015021-pol2qm74	3726	46	cells	cell	NNS
cord-015021-pol2qm74	3726	47	(	(	-LRB-
cord-015021-pol2qm74	3726	48	PBMC	PBMC	NNP
cord-015021-pol2qm74	3726	49	)	)	-RRB-
cord-015021-pol2qm74	3726	50	obtained	obtain	VBD
cord-015021-pol2qm74	3726	51	from	from	IN
cord-015021-pol2qm74	3726	52	healthy	healthy	JJ
cord-015021-pol2qm74	3726	53	blood	blood	NN
cord-015021-pol2qm74	3726	54	donors	donor	NNS
cord-015021-pol2qm74	3726	55	.	.	.
cord-015021-pol2qm74	3727	1	The	the	DT
cord-015021-pol2qm74	3727	2	induction	induction	NN
cord-015021-pol2qm74	3727	3	and	and	CC
cord-015021-pol2qm74	3727	4	kinetics	kinetic	NNS
cord-015021-pol2qm74	3727	5	of	of	IN
cord-015021-pol2qm74	3727	6	14	14	CD
cord-015021-pol2qm74	3727	7	different	different	JJ
cord-015021-pol2qm74	3727	8	cytokines	cytokine	NNS
cord-015021-pol2qm74	3727	9	was	be	VBD
cord-015021-pol2qm74	3727	10	studied	study	VBN
cord-015021-pol2qm74	3727	11	at	at	IN
cord-015021-pol2qm74	3727	12	single	single	JJ
cord-015021-pol2qm74	3727	13	-	-	HYPH
cord-015021-pol2qm74	3727	14	cell	cell	NN
cord-015021-pol2qm74	3727	15	level	level	NN
cord-015021-pol2qm74	3727	16	using	use	VBG
cord-015021-pol2qm74	3727	17	cytokine	cytokine	JJ
cord-015021-pol2qm74	3727	18	specific	specific	JJ
cord-015021-pol2qm74	3727	19	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	3727	20	antibodies	antibody	NNS
cord-015021-pol2qm74	3727	21	and	and	CC
cord-015021-pol2qm74	3727	22	intracellular	intracellular	JJ
cord-015021-pol2qm74	3727	23	immunofluorescent	immunofluorescent	JJ
cord-015021-pol2qm74	3727	24	staining	staining	NN
cord-015021-pol2qm74	3727	25	.	.	.
cord-015021-pol2qm74	3728	1	All	all	DT
cord-015021-pol2qm74	3728	2	three	three	CD
cord-015021-pol2qm74	3728	3	mitogens	mitogen	NNS
cord-015021-pol2qm74	3728	4	induced	induce	VBN
cord-015021-pol2qm74	3728	5	a	a	DT
cord-015021-pol2qm74	3728	6	massive	massive	JJ
cord-015021-pol2qm74	3728	7	IFNy	ifny	NN
cord-015021-pol2qm74	3728	8	and	and	CC
cord-015021-pol2qm74	3728	9	TNFI3	TNFI3	NNP
cord-015021-pol2qm74	3728	10	response	response	NN
cord-015021-pol2qm74	3728	11	in	in	IN
cord-015021-pol2qm74	3728	12	10	10	CD
cord-015021-pol2qm74	3728	13	-	-	SYM
cord-015021-pol2qm74	3728	14	16	16	CD
cord-015021-pol2qm74	3728	15	%	%	NN
cord-015021-pol2qm74	3728	16	of	of	IN
cord-015021-pol2qm74	3728	17	the	the	DT
cord-015021-pol2qm74	3728	18	PBMC	PBMC	NNP
cord-015021-pol2qm74	3728	19	after	after	IN
cord-015021-pol2qm74	3728	20	48	48	CD
cord-015021-pol2qm74	3728	21	-	-	SYM
cord-015021-pol2qm74	3728	22	96	96	CD
cord-015021-pol2qm74	3728	23	hours	hour	NNS
cord-015021-pol2qm74	3728	24	of	of	IN
cord-015021-pol2qm74	3728	25	cell	cell	NN
cord-015021-pol2qm74	3728	26	stimulation	stimulation	NN
cord-015021-pol2qm74	3728	27	.	.	.
cord-015021-pol2qm74	3729	1	In	in	IN
cord-015021-pol2qm74	3729	2	contrast	contrast	NN
cord-015021-pol2qm74	3729	3	,	,	,
cord-015021-pol2qm74	3729	4	IL2	IL2	NNP
cord-015021-pol2qm74	3729	5	and	and	CC
cord-015021-pol2qm74	3729	6	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	3729	7	containing	contain	VBG
cord-015021-pol2qm74	3729	8	cells	cell	NNS
cord-015021-pol2qm74	3729	9	was	be	VBD
cord-015021-pol2qm74	3729	10	only	only	RB
cord-015021-pol2qm74	3729	11	detected	detect	VBN
cord-015021-pol2qm74	3729	12	in	in	IN
cord-015021-pol2qm74	3729	13	1	1	CD
cord-015021-pol2qm74	3729	14	-	-	SYM
cord-015021-pol2qm74	3729	15	3	3	CD
cord-015021-pol2qm74	3729	16	%	%	NN
cord-015021-pol2qm74	3729	17	of	of	IN
cord-015021-pol2qm74	3729	18	the	the	DT
cord-015021-pol2qm74	3729	19	PBMC	PBMC	NNP
cord-015021-pol2qm74	3729	20	.	.	.
cord-015021-pol2qm74	3730	1	The	the	DT
cord-015021-pol2qm74	3730	2	induction	induction	NN
cord-015021-pol2qm74	3730	3	ofIL3	ofIL3	NNP
cord-015021-pol2qm74	3730	4	,	,	,
cord-015021-pol2qm74	3730	5	IL4	il4	NN
cord-015021-pol2qm74	3730	6	,	,	,
cord-015021-pol2qm74	3730	7	IL5	IL5	NNP
cord-015021-pol2qm74	3730	8	,	,	,
cord-015021-pol2qm74	3730	9	and	and	CC
cord-015021-pol2qm74	3730	10	ILl0	ILl0	NNP
cord-015021-pol2qm74	3730	11	,	,	,
cord-015021-pol2qm74	3730	12	was	be	VBD
cord-015021-pol2qm74	3730	13	weak	weak	JJ
cord-015021-pol2qm74	3730	14	or	or	CC
cord-015021-pol2qm74	3730	15	completely	completely	RB
cord-015021-pol2qm74	3730	16	absent	absent	JJ
cord-015021-pol2qm74	3730	17	.	.	.
cord-015021-pol2qm74	3731	1	Thus	thus	RB
cord-015021-pol2qm74	3731	2	,	,	,
cord-015021-pol2qm74	3731	3	the	the	DT
cord-015021-pol2qm74	3731	4	response	response	NN
cord-015021-pol2qm74	3731	5	indicates	indicate	VBZ
cord-015021-pol2qm74	3731	6	activation	activation	NN
cord-015021-pol2qm74	3731	7	of	of	IN
cord-015021-pol2qm74	3731	8	TH1	th1	NN
cord-015021-pol2qm74	3731	9	cells	cell	NNS
cord-015021-pol2qm74	3731	10	.	.	.
cord-015021-pol2qm74	3732	1	However	however	RB
cord-015021-pol2qm74	3732	2	,	,	,
cord-015021-pol2qm74	3732	3	ILlc~	illc~	NN
cord-015021-pol2qm74	3732	4	,	,	,
cord-015021-pol2qm74	3732	5	ILll3	ILll3	NNP
cord-015021-pol2qm74	3732	6	,	,	,
cord-015021-pol2qm74	3732	7	ILlra	ILlra	NNP
cord-015021-pol2qm74	3732	8	and	and	CC
cord-015021-pol2qm74	3732	9	IL8	IL8	NNP
cord-015021-pol2qm74	3732	10	,	,	,
cord-015021-pol2qm74	3732	11	were	be	VBD
cord-015021-pol2qm74	3732	12	consistently	consistently	RB
cord-015021-pol2qm74	3732	13	found	find	VBN
cord-015021-pol2qm74	3732	14	and	and	CC
cord-015021-pol2qm74	3732	15	gradually	gradually	RB
cord-015021-pol2qm74	3732	16	produced	produce	VBN
cord-015021-pol2qm74	3732	17	,	,	,
cord-015021-pol2qm74	3732	18	peaking	peak	VBG
cord-015021-pol2qm74	3732	19	at	at	IN
cord-015021-pol2qm74	3732	20	24	24	CD
cord-015021-pol2qm74	3732	21	hems	hem	NNS
cord-015021-pol2qm74	3732	22	in	in	IN
cord-015021-pol2qm74	3732	23	approximately	approximately	RB
cord-015021-pol2qm74	3732	24	5	5	CD
cord-015021-pol2qm74	3732	25	-	-	SYM
cord-015021-pol2qm74	3732	26	8	8	CD
cord-015021-pol2qm74	3732	27	%	%	NN
cord-015021-pol2qm74	3732	28	of	of	IN
cord-015021-pol2qm74	3732	29	the	the	DT
cord-015021-pol2qm74	3732	30	PBMC	PBMC	NNP
cord-015021-pol2qm74	3732	31	.	.	.
cord-015021-pol2qm74	3733	1	MF	MF	NNP
cord-015021-pol2qm74	3733	2	induced	induce	VBD
cord-015021-pol2qm74	3733	3	an	an	DT
cord-015021-pol2qm74	3733	4	equally	equally	RB
cord-015021-pol2qm74	3733	5	extensive	extensive	JJ
cord-015021-pol2qm74	3733	6	cytokine	cytokine	NN
cord-015021-pol2qm74	3733	7	as	as	RB
cord-015021-pol2qm74	3733	8	well	well	RB
cord-015021-pol2qm74	3733	9	as	as	IN
cord-015021-pol2qm74	3733	10	proliferative	proliferative	JJ
cord-015021-pol2qm74	3733	11	inducing	induce	VBG
cord-015021-pol2qm74	3733	12	capacity	capacity	NN
cord-015021-pol2qm74	3733	13	,	,	,
cord-015021-pol2qm74	3733	14	as	as	IN
cord-015021-pol2qm74	3733	15	did	do	VBD
cord-015021-pol2qm74	3733	16	SpeA	SpeA	NNP
cord-015021-pol2qm74	3733	17	and	and	CC
cord-015021-pol2qm74	3733	18	SpeB	SpeB	NNP
cord-015021-pol2qm74	3733	19	,	,	,
cord-015021-pol2qm74	3733	20	which	which	WDT
cord-015021-pol2qm74	3733	21	suggests	suggest	VBZ
cord-015021-pol2qm74	3733	22	that	that	IN
cord-015021-pol2qm74	3733	23	also	also	RB
cord-015021-pol2qm74	3733	24	MF	MF	NNP
cord-015021-pol2qm74	3733	25	is	be	VBZ
cord-015021-pol2qm74	3733	26	a	a	DT
cord-015021-pol2qm74	3733	27	superantigen	superantigen	NN
cord-015021-pol2qm74	3733	28	.	.	.
cord-015021-pol2qm74	3734	1	A	a	DT
cord-015021-pol2qm74	3734	2	marked	marked	JJ
cord-015021-pol2qm74	3734	3	inter	inter	JJ
cord-015021-pol2qm74	3734	4	-	-	JJ
cord-015021-pol2qm74	3734	5	individual	individual	JJ
cord-015021-pol2qm74	3734	6	variation	variation	NN
cord-015021-pol2qm74	3734	7	could	could	MD
cord-015021-pol2qm74	3734	8	be	be	VB
cord-015021-pol2qm74	3734	9	noted	note	VBN
cord-015021-pol2qm74	3734	10	between	between	IN
cord-015021-pol2qm74	3734	11	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	3734	12	isolated	isolate	VBN
cord-015021-pol2qm74	3734	13	from	from	IN
cord-015021-pol2qm74	3734	14	different	different	JJ
cord-015021-pol2qm74	3734	15	individuals	individual	NNS
cord-015021-pol2qm74	3734	16	,	,	,
cord-015021-pol2qm74	3734	17	both	both	CC
cord-015021-pol2qm74	3734	18	in	in	IN
cord-015021-pol2qm74	3734	19	the	the	DT
cord-015021-pol2qm74	3734	20	toxin	toxin	NN
cord-015021-pol2qm74	3734	21	induced	induce	VBN
cord-015021-pol2qm74	3734	22	proliferation	proliferation	NN
cord-015021-pol2qm74	3734	23	and	and	CC
cord-015021-pol2qm74	3734	24	cytokine	cytokine	NN
cord-015021-pol2qm74	3734	25	induction	induction	NN
cord-015021-pol2qm74	3734	26	.	.	.
cord-015021-pol2qm74	3735	1	This	this	DT
cord-015021-pol2qm74	3735	2	may	may	MD
cord-015021-pol2qm74	3735	3	be	be	VB
cord-015021-pol2qm74	3735	4	one	one	CD
cord-015021-pol2qm74	3735	5	explanation	explanation	NN
cord-015021-pol2qm74	3735	6	for	for	IN
cord-015021-pol2qm74	3735	7	the	the	DT
cord-015021-pol2qm74	3735	8	varying	vary	VBG
cord-015021-pol2qm74	3735	9	clinical	clinical	JJ
cord-015021-pol2qm74	3735	10	severity	severity	NN
cord-015021-pol2qm74	3735	11	noted	note	VBN
cord-015021-pol2qm74	3735	12	in	in	IN
cord-015021-pol2qm74	3735	13	patients	patient	NNS
cord-015021-pol2qm74	3735	14	after	after	IN
cord-015021-pol2qm74	3735	15	infection	infection	NN
cord-015021-pol2qm74	3735	16	with	with	IN
cord-015021-pol2qm74	3735	17	clonal	clonal	JJ
cord-015021-pol2qm74	3735	18	GAS	gas	NN
cord-015021-pol2qm74	3735	19	strains	strain	NNS
cord-015021-pol2qm74	3735	20	.	.	.
cord-015021-pol2qm74	3736	1	Introduction	introduction	NN
cord-015021-pol2qm74	3736	2	-Tumour	-Tumour	HYPH
cord-015021-pol2qm74	3736	3	necrosis	necrosis	NN
cord-015021-pol2qm74	3736	4	factor	factor	NN
cord-015021-pol2qm74	3736	5	(	(	-LRB-
cord-015021-pol2qm74	3736	6	TNF	TNF	NNP
cord-015021-pol2qm74	3736	7	)	)	-RRB-
cord-015021-pol2qm74	3736	8	is	be	VBZ
cord-015021-pol2qm74	3736	9	released	release	VBN
cord-015021-pol2qm74	3736	10	by	by	IN
cord-015021-pol2qm74	3736	11	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	3736	12	cells	cell	NNS
cord-015021-pol2qm74	3736	13	in	in	IN
cord-015021-pol2qm74	3736	14	response	response	NN
cord-015021-pol2qm74	3736	15	to	to	IN
cord-015021-pol2qm74	3736	16	inflammation	inflammation	NN
cord-015021-pol2qm74	3736	17	and	and	CC
cord-015021-pol2qm74	3736	18	sepsis	sepsis	NN
cord-015021-pol2qm74	3736	19	.	.	.
cord-015021-pol2qm74	3737	1	It	-PRON-	PRP
cord-015021-pol2qm74	3737	2	has	have	VBZ
cord-015021-pol2qm74	3737	3	been	be	VBN
cord-015021-pol2qm74	3737	4	implicated	implicate	VBN
cord-015021-pol2qm74	3737	5	as	as	IN
cord-015021-pol2qm74	3737	6	a	a	DT
cord-015021-pol2qm74	3737	7	possible	possible	JJ
cord-015021-pol2qm74	3737	8	mediator	mediator	NN
cord-015021-pol2qm74	3737	9	in	in	IN
cord-015021-pol2qm74	3737	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3737	11	bowel	bowel	NN
cord-015021-pol2qm74	3737	12	disease	disease	NN
cord-015021-pol2qm74	3737	13	(	(	-LRB-
cord-015021-pol2qm74	3737	14	IBD	IBD	NNP
cord-015021-pol2qm74	3737	15	)	)	-RRB-
cord-015021-pol2qm74	3737	16	but	but	CC
cord-015021-pol2qm74	3737	17	its	-PRON-	PRP$
cord-015021-pol2qm74	3737	18	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	3737	19	role	role	NN
cord-015021-pol2qm74	3737	20	remains	remain	VBZ
cord-015021-pol2qm74	3737	21	uncertain	uncertain	JJ
cord-015021-pol2qm74	3737	22	.	.	.
cord-015021-pol2qm74	3738	1	This	this	DT
cord-015021-pol2qm74	3738	2	study	study	NN
cord-015021-pol2qm74	3738	3	assessed	assess	VBD
cord-015021-pol2qm74	3738	4	the	the	DT
cord-015021-pol2qm74	3738	5	relationship	relationship	NN
cord-015021-pol2qm74	3738	6	between	between	IN
cord-015021-pol2qm74	3738	7	TNFct	TNFct	NNP
cord-015021-pol2qm74	3738	8	and	and	CC
cord-015021-pol2qm74	3738	9	disease	disease	NN
cord-015021-pol2qm74	3738	10	activity	activity	NN
cord-015021-pol2qm74	3738	11	by	by	IN
cord-015021-pol2qm74	3738	12	measuring	measure	VBG
cord-015021-pol2qm74	3738	13	plasma	plasma	NN
cord-015021-pol2qm74	3738	14	and	and	CC
cord-015021-pol2qm74	3738	15	faecal	faecal	JJ
cord-015021-pol2qm74	3738	16	TNF	TNF	NNP
cord-015021-pol2qm74	3738	17	concelnmtions	concelnmtion	NNS
cord-015021-pol2qm74	3738	18	in	in	IN
cord-015021-pol2qm74	3738	19	an	an	DT
cord-015021-pol2qm74	3738	20	experimcntaI	experimcntaI	NNP
cord-015021-pol2qm74	3738	21	model	model	NN
cord-015021-pol2qm74	3738	22	of	of	IN
cord-015021-pol2qm74	3738	23	IBD	IBD	NNP
cord-015021-pol2qm74	3738	24	.	.	.
cord-015021-pol2qm74	3739	1	Methodologo	Methodologo	NNP
cord-015021-pol2qm74	3739	2	'	'	POS
cord-015021-pol2qm74	3739	3	-Colitis	-colitis	WP
cord-015021-pol2qm74	3739	4	was	be	VBD
cord-015021-pol2qm74	3739	5	induced	induce	VBN
cord-015021-pol2qm74	3739	6	in	in	IN
cord-015021-pol2qm74	3739	7	male	male	JJ
cord-015021-pol2qm74	3739	8	Wistar	Wistar	NNP
cord-015021-pol2qm74	3739	9	rats	rat	NNS
cord-015021-pol2qm74	3739	10	by	by	IN
cord-015021-pol2qm74	3739	11	intmcolonic	intmcolonic	JJ
cord-015021-pol2qm74	3739	12	instillation	instillation	NN
cord-015021-pol2qm74	3739	13	of	of	IN
cord-015021-pol2qm74	3739	14	30rag	30rag	NNP
cord-015021-pol2qm74	3739	15	2,4,6-trinitrobenzenesulphunic	2,4,6-trinitrobenzenesulphunic	CD
cord-015021-pol2qm74	3739	16	acid	acid	NN
cord-015021-pol2qm74	3739	17	in	in	IN
cord-015021-pol2qm74	3739	18	0.5mL	0.5ml	CD
cord-015021-pol2qm74	3739	19	50	50	CD
cord-015021-pol2qm74	3739	20	%	%	NN
cord-015021-pol2qm74	3739	21	ethanol	ethanol	NN
cord-015021-pol2qm74	3739	22	(	(	-LRB-
cord-015021-pol2qm74	3739	23	n=12	n=12	NNP
cord-015021-pol2qm74	3739	24	)	)	-RRB-
cord-015021-pol2qm74	3739	25	.	.	.
cord-015021-pol2qm74	3740	1	Control	control	NN
cord-015021-pol2qm74	3740	2	animals	animal	NNS
cord-015021-pol2qm74	3740	3	received	receive	VBD
cord-015021-pol2qm74	3740	4	an	an	DT
cord-015021-pol2qm74	3740	5	isovohlmetric	isovohlmetric	JJ
cord-015021-pol2qm74	3740	6	instillation	instillation	NN
cord-015021-pol2qm74	3740	7	of	of	IN
cord-015021-pol2qm74	3740	8	normal	normal	JJ
cord-015021-pol2qm74	3740	9	saline	saline	NN
cord-015021-pol2qm74	3740	10	(	(	-LRB-
cord-015021-pol2qm74	3740	11	n=12	n=12	NNP
cord-015021-pol2qm74	3740	12	)	)	-RRB-
cord-015021-pol2qm74	3740	13	.	.	.
cord-015021-pol2qm74	3741	1	Faecal	Faecal	NNP
cord-015021-pol2qm74	3741	2	pellets	pellet	NNS
cord-015021-pol2qm74	3741	3	were	be	VBD
cord-015021-pol2qm74	3741	4	collected	collect	VBN
cord-015021-pol2qm74	3741	5	before	before	IN
cord-015021-pol2qm74	3741	6	induction	induction	NN
cord-015021-pol2qm74	3741	7	of	of	IN
cord-015021-pol2qm74	3741	8	colitis	colitis	NN
cord-015021-pol2qm74	3741	9	(	(	-LRB-
cord-015021-pol2qm74	3741	10	Day	Day	NNP
cord-015021-pol2qm74	3741	11	0	0	CD
cord-015021-pol2qm74	3741	12	)	)	-RRB-
cord-015021-pol2qm74	3741	13	and	and	CC
cord-015021-pol2qm74	3741	14	throughout	throughout	IN
cord-015021-pol2qm74	3741	15	the	the	DT
cord-015021-pol2qm74	3741	16	experiment	experiment	NN
cord-015021-pol2qm74	3741	17	.	.	.
cord-015021-pol2qm74	3742	1	After	after	IN
cord-015021-pol2qm74	3742	2	8	8	CD
cord-015021-pol2qm74	3742	3	days	day	NNS
cord-015021-pol2qm74	3742	4	the	the	DT
cord-015021-pol2qm74	3742	5	colon	colon	NN
cord-015021-pol2qm74	3742	6	was	be	VBD
cord-015021-pol2qm74	3742	7	excised	excise	VBN
cord-015021-pol2qm74	3742	8	,	,	,
cord-015021-pol2qm74	3742	9	ueighed	ueighed	JJ
cord-015021-pol2qm74	3742	10	and	and	CC
cord-015021-pol2qm74	3742	11	the	the	DT
cord-015021-pol2qm74	3742	12	colon	colon	NN
cord-015021-pol2qm74	3742	13	macroscopic	macroscopic	JJ
cord-015021-pol2qm74	3742	14	score	score	NN
cord-015021-pol2qm74	3742	15	(	(	-LRB-
cord-015021-pol2qm74	3742	16	CMS	CMS	NNP
cord-015021-pol2qm74	3742	17	)	)	-RRB-
cord-015021-pol2qm74	3742	18	assessed	assess	VBN
cord-015021-pol2qm74	3743	1	Plasma	Plasma	NNP
cord-015021-pol2qm74	3743	2	TNF	TNF	NNP
cord-015021-pol2qm74	3743	3	(	(	-LRB-
cord-015021-pol2qm74	3743	4	pTNF	ptnf	NN
cord-015021-pol2qm74	3743	5	)	)	-RRB-
cord-015021-pol2qm74	3743	6	samples	sample	NNS
cord-015021-pol2qm74	3743	7	were	be	VBD
cord-015021-pol2qm74	3743	8	assayed	assay	VBN
cord-015021-pol2qm74	3743	9	by	by	IN
cord-015021-pol2qm74	3743	10	bioassay	bioassay	NN
cord-015021-pol2qm74	3743	11	and	and	CC
cord-015021-pol2qm74	3743	12	ELISA	ELISA	NNP
cord-015021-pol2qm74	3743	13	.	.	.
cord-015021-pol2qm74	3744	1	Faecal	Faecal	NNP
cord-015021-pol2qm74	3744	2	samples	sample	NNS
cord-015021-pol2qm74	3744	3	were	be	VBD
cord-015021-pol2qm74	3744	4	vortcxed	vortcxe	VBN
cord-015021-pol2qm74	3744	5	in	in	IN
cord-015021-pol2qm74	3744	6	water	water	NN
cord-015021-pol2qm74	3744	7	and	and	CC
cord-015021-pol2qm74	3744	8	the	the	DT
cord-015021-pol2qm74	3744	9	supernatant	supernatant	NN
cord-015021-pol2qm74	3744	10	removed	remove	VBN
cord-015021-pol2qm74	3744	11	for	for	IN
cord-015021-pol2qm74	3744	12	estimation	estimation	NN
cord-015021-pol2qm74	3744	13	of	of	IN
cord-015021-pol2qm74	3744	14	protein	protein	NN
cord-015021-pol2qm74	3744	15	and	and	CC
cord-015021-pol2qm74	3744	16	faecal	faecal	JJ
cord-015021-pol2qm74	3744	17	TNF	TNF	NNP
cord-015021-pol2qm74	3744	18	(	(	-LRB-
cord-015021-pol2qm74	3744	19	iTNF	itnf	NN
cord-015021-pol2qm74	3744	20	)	)	-RRB-
cord-015021-pol2qm74	3744	21	content	content	NN
cord-015021-pol2qm74	3744	22	(	(	-LRB-
cord-015021-pol2qm74	3744	23	ELISA	ELISA	NNP
cord-015021-pol2qm74	3744	24	)	)	-RRB-
cord-015021-pol2qm74	3744	25	.	.	.
cord-015021-pol2qm74	3745	1	There	there	EX
cord-015021-pol2qm74	3745	2	is	be	VBZ
cord-015021-pol2qm74	3745	3	a	a	DT
cord-015021-pol2qm74	3745	4	significant	significant	JJ
cord-015021-pol2qm74	3745	5	increase	increase	NN
cord-015021-pol2qm74	3745	6	in	in	IN
cord-015021-pol2qm74	3745	7	ITNF	ITNF	NNP
cord-015021-pol2qm74	3745	8	on	on	IN
cord-015021-pol2qm74	3745	9	day	day	NN
cord-015021-pol2qm74	3745	10	4	4	CD
cord-015021-pol2qm74	3745	11	-#p=0	-#p=0	SYM
cord-015021-pol2qm74	3745	12	02	02	CD
cord-015021-pol2qm74	3745	13	alld	alld	NNP
cord-015021-pol2qm74	3745	14	the	the	DT
cord-015021-pol2qm74	3745	15	total	total	JJ
cord-015021-pol2qm74	3745	16	fTNF	ftnf	NN
cord-015021-pol2qm74	3745	17	measured	measure	VBN
cord-015021-pol2qm74	3745	18	during	during	IN
cord-015021-pol2qm74	3745	19	the	the	DT
cord-015021-pol2qm74	3745	20	study	study	NN
cord-015021-pol2qm74	3745	21	correlatcs	correlatc	NNS
cord-015021-pol2qm74	3745	22	with	with	IN
cord-015021-pol2qm74	3745	23	the	the	DT
cord-015021-pol2qm74	3745	24	CMS	CMS	NNP
cord-015021-pol2qm74	3745	25	oll	oll	NNP
cord-015021-pol2qm74	3745	26	day	day	NN
cord-015021-pol2qm74	3745	27	8	8	CD
cord-015021-pol2qm74	3746	1	-p=0.04	-p=0.04	NNP
cord-015021-pol2qm74	3747	1	There	there	EX
cord-015021-pol2qm74	3747	2	is	be	VBZ
cord-015021-pol2qm74	3747	3	no	no	DT
cord-015021-pol2qm74	3747	4	correlation	correlation	NN
cord-015021-pol2qm74	3747	5	between	between	IN
cord-015021-pol2qm74	3747	6	fTNF	ftnf	NN
cord-015021-pol2qm74	3747	7	and	and	CC
cord-015021-pol2qm74	3747	8	pTNF	ptnf	NN
cord-015021-pol2qm74	3747	9	.	.	.
cord-015021-pol2qm74	3748	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	3748	2	-Therc	-Therc	VBZ
cord-015021-pol2qm74	3748	3	is	be	VBZ
cord-015021-pol2qm74	3748	4	evidence	evidence	NN
cord-015021-pol2qm74	3748	5	of	of	IN
cord-015021-pol2qm74	3748	6	coloific	coloific	NNP
cord-015021-pol2qm74	3748	7	TNF	TNF	NNP
cord-015021-pol2qm74	3748	8	excretion	excretion	NN
cord-015021-pol2qm74	3748	9	by	by	IN
cord-015021-pol2qm74	3748	10	macroscopically	macroscopically	RB
cord-015021-pol2qm74	3748	11	normal	normal	JJ
cord-015021-pol2qm74	3748	12	animals	animal	NNS
cord-015021-pol2qm74	3748	13	and	and	CC
cord-015021-pol2qm74	3748	14	following	follow	VBG
cord-015021-pol2qm74	3748	15	induction	induction	NN
cord-015021-pol2qm74	3748	16	of	of	IN
cord-015021-pol2qm74	3748	17	colitis	colitis	NN
cord-015021-pol2qm74	3749	1	there	there	EX
cord-015021-pol2qm74	3749	2	is	be	VBZ
cord-015021-pol2qm74	3749	3	increased	increase	VBN
cord-015021-pol2qm74	3749	4	faecal	faecal	JJ
cord-015021-pol2qm74	3749	5	TNF	TNF	NNP
cord-015021-pol2qm74	3749	6	which	which	WDT
cord-015021-pol2qm74	3749	7	correlates	correlate	VBZ
cord-015021-pol2qm74	3749	8	with	with	IN
cord-015021-pol2qm74	3749	9	disease	disease	NN
cord-015021-pol2qm74	3749	10	actMty	actMty	NNP
cord-015021-pol2qm74	3749	11	.	.	.
cord-015021-pol2qm74	3750	1	There	there	EX
cord-015021-pol2qm74	3750	2	is	be	VBZ
cord-015021-pol2qm74	3750	3	no	no	DT
cord-015021-pol2qm74	3750	4	significant	significant	JJ
cord-015021-pol2qm74	3750	5	elevation	elevation	NN
cord-015021-pol2qm74	3750	6	in	in	IN
cord-015021-pol2qm74	3750	7	bioactive	bioactive	JJ
cord-015021-pol2qm74	3750	8	or	or	CC
cord-015021-pol2qm74	3750	9	imnmnoreactive	imnmnoreactive	NNP
cord-015021-pol2qm74	3750	10	plasma	plasma	NN
cord-015021-pol2qm74	3750	11	TNF	TNF	NNP
cord-015021-pol2qm74	3750	12	in	in	IN
cord-015021-pol2qm74	3750	13	colitie	colitie	NN
cord-015021-pol2qm74	3750	14	animals	animal	NNS
cord-015021-pol2qm74	3751	1	This	this	DT
cord-015021-pol2qm74	3751	2	data	datum	NNS
cord-015021-pol2qm74	3751	3	would	would	MD
cord-015021-pol2qm74	3751	4	suggest	suggest	VB
cord-015021-pol2qm74	3751	5	that	that	IN
cord-015021-pol2qm74	3751	6	faecal	faecal	JJ
cord-015021-pol2qm74	3751	7	TNF	TNF	NNP
cord-015021-pol2qm74	3751	8	is	be	VBZ
cord-015021-pol2qm74	3751	9	a	a	DT
cord-015021-pol2qm74	3751	10	marker	marker	NN
cord-015021-pol2qm74	3751	11	of	of	IN
cord-015021-pol2qm74	3751	12	colonic	colonic	JJ
cord-015021-pol2qm74	3751	13	inflamrnatiort	inflamrnatiort	NNP
cord-015021-pol2qm74	3751	14	and	and	CC
cord-015021-pol2qm74	3751	15	serial	serial	JJ
cord-015021-pol2qm74	3751	16	TNF	TNF	NNP
cord-015021-pol2qm74	3751	17	assessment	assessment	NN
cord-015021-pol2qm74	3751	18	inay	inay	NNP
cord-015021-pol2qm74	3751	19	be	be	VB
cord-015021-pol2qm74	3751	20	useful	useful	JJ
cord-015021-pol2qm74	3751	21	as	as	IN
cord-015021-pol2qm74	3751	22	an	an	DT
cord-015021-pol2qm74	3751	23	indicator	indicator	NN
cord-015021-pol2qm74	3751	24	&	&	CC
cord-015021-pol2qm74	3751	25	severity	severity	NN
cord-015021-pol2qm74	3751	26	in	in	IN
cord-015021-pol2qm74	3751	27	IBD	IBD	NNP
cord-015021-pol2qm74	3751	28	.	.	.
cord-015021-pol2qm74	3751	29	 	 	_SP
cord-015021-pol2qm74	3752	1	To	to	TO
cord-015021-pol2qm74	3752	2	study	study	VB
cord-015021-pol2qm74	3752	3	the	the	DT
cord-015021-pol2qm74	3752	4	effect	effect	NN
cord-015021-pol2qm74	3752	5	of	of	IN
cord-015021-pol2qm74	3752	6	in	in	IN
cord-015021-pol2qm74	3752	7	-	-	HYPH
cord-015021-pol2qm74	3752	8	vivo	vivo	NN
cord-015021-pol2qm74	3752	9	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3752	10	/	/	SYM
cord-015021-pol2qm74	3752	11	reoxygenation	reoxygenation	NN
cord-015021-pol2qm74	3752	12	on	on	IN
cord-015021-pol2qm74	3752	13	cytokine	cytokine	JJ
cord-015021-pol2qm74	3752	14	elaboration	elaboration	NN
cord-015021-pol2qm74	3752	15	by	by	IN
cord-015021-pol2qm74	3752	16	routine	routine	JJ
cord-015021-pol2qm74	3752	17	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	3752	18	macrophages	macrophage	NNS
cord-015021-pol2qm74	3752	19	.	.	.
cord-015021-pol2qm74	3753	1	Materials	material	NNS
cord-015021-pol2qm74	3753	2	and	and	CC
cord-015021-pol2qm74	3753	3	Methods	method	NNS
cord-015021-pol2qm74	3753	4	:	:	:
cord-015021-pol2qm74	3753	5	Adult	adult	JJ
cord-015021-pol2qm74	3753	6	male	male	JJ
cord-015021-pol2qm74	3753	7	CBA	CBA	NNP
cord-015021-pol2qm74	3753	8	mice	mouse	NNS
cord-015021-pol2qm74	3753	9	(	(	-LRB-
cord-015021-pol2qm74	3753	10	20	20	CD
cord-015021-pol2qm74	3753	11	-	-	SYM
cord-015021-pol2qm74	3753	12	25	25	CD
cord-015021-pol2qm74	3753	13	g	g	NN
cord-015021-pol2qm74	3753	14	)	)	-RRB-
cord-015021-pol2qm74	3753	15	were	be	VBD
cord-015021-pol2qm74	3753	16	primed	prime	VBN
cord-015021-pol2qm74	3753	17	intraperitoneaUy	intraperitoneauy	NN
cord-015021-pol2qm74	3753	18	with	with	IN
cord-015021-pol2qm74	3753	19	either	either	DT
cord-015021-pol2qm74	3753	20	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3753	21	(	(	-LRB-
cord-015021-pol2qm74	3753	22	LPS	LPS	NNP
cord-015021-pol2qm74	3753	23	)	)	-RRB-
cord-015021-pol2qm74	3753	24	10ug]anlmal	10ug]anlmal	CD
cord-015021-pol2qm74	3753	25	or	or	CC
cord-015021-pol2qm74	3753	26	saline	saline	NN
cord-015021-pol2qm74	3753	27	.	.	.
cord-015021-pol2qm74	3754	1	Five	five	CD
cord-015021-pol2qm74	3754	2	days	day	NNS
cord-015021-pol2qm74	3754	3	later	later	RB
cord-015021-pol2qm74	3754	4	,	,	,
cord-015021-pol2qm74	3754	5	the	the	DT
cord-015021-pol2qm74	3754	6	animals	animal	NNS
cord-015021-pol2qm74	3754	7	were	be	VBD
cord-015021-pol2qm74	3754	8	subjected	subject	VBN
cord-015021-pol2qm74	3754	9	to	to	IN
cord-015021-pol2qm74	3754	10	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3754	11	(	(	-LRB-
cord-015021-pol2qm74	3754	12	8%02	8%02	NNP
cord-015021-pol2qm74	3754	13	)	)	-RRB-
cord-015021-pol2qm74	3754	14	for	for	IN
cord-015021-pol2qm74	3754	15	160	160	CD
cord-015021-pol2qm74	3754	16	,	,	,
cord-015021-pol2qm74	3754	17	followed	follow	VBN
cord-015021-pol2qm74	3754	18	by	by	IN
cord-015021-pol2qm74	3754	19	20	20	CD
cord-015021-pol2qm74	3754	20	of	of	IN
cord-015021-pol2qm74	3754	21	normoxia	normoxia	NN
cord-015021-pol2qm74	3754	22	.	.	.
cord-015021-pol2qm74	3755	1	Harvested	harvest	VBN
cord-015021-pol2qm74	3755	2	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	3755	3	macrophages	macrophage	NNS
cord-015021-pol2qm74	3755	4	were	be	VBD
cord-015021-pol2qm74	3755	5	plated	plate	VBN
cord-015021-pol2qm74	3755	6	in	in	IN
cord-015021-pol2qm74	3755	7	-	-	HYPH
cord-015021-pol2qm74	3755	8	vitro	vitro	FW
cord-015021-pol2qm74	3755	9	,	,	,
cord-015021-pol2qm74	3755	10	culture	culture	NN
cord-015021-pol2qm74	3755	11	supernatants	supernatant	NNS
cord-015021-pol2qm74	3755	12	were	be	VBD
cord-015021-pol2qm74	3755	13	collected	collect	VBN
cord-015021-pol2qm74	3755	14	at	at	IN
cord-015021-pol2qm74	3755	15	20	20	CD
cord-015021-pol2qm74	3755	16	,	,	,
cord-015021-pol2qm74	3755	17	40	40	CD
cord-015021-pol2qm74	3755	18	,	,	,
cord-015021-pol2qm74	3755	19	and	and	CC
cord-015021-pol2qm74	3755	20	60	60	CD
cord-015021-pol2qm74	3755	21	and	and	CC
cord-015021-pol2qm74	3755	22	assayed	assay	VBN
cord-015021-pol2qm74	3755	23	for	for	IN
cord-015021-pol2qm74	3755	24	tumor	tumor	NN
cord-015021-pol2qm74	3755	25	necrosis	necrosis	NN
cord-015021-pol2qm74	3755	26	factor	factor	NN
cord-015021-pol2qm74	3755	27	(	(	-LRB-
cord-015021-pol2qm74	3755	28	TNF	TNF	NNP
cord-015021-pol2qm74	3755	29	)	)	-RRB-
cord-015021-pol2qm74	3755	30	,	,	,
cord-015021-pol2qm74	3755	31	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	3755	32	E2	e2	NN
cord-015021-pol2qm74	3755	33	(	(	-LRB-
cord-015021-pol2qm74	3755	34	PGE2	PGE2	NNP
cord-015021-pol2qm74	3755	35	)	)	-RRB-
cord-015021-pol2qm74	3755	36	and	and	CC
cord-015021-pol2qm74	3755	37	nitric	nitric	NN
cord-015021-pol2qm74	3755	38	oxide	oxide	NN
cord-015021-pol2qm74	3755	39	(	(	-LRB-
cord-015021-pol2qm74	3755	40	NO	no	RB
cord-015021-pol2qm74	3755	41	)	)	-RRB-
cord-015021-pol2qm74	3755	42	.	.	.
cord-015021-pol2qm74	3756	1	Control	control	NN
cord-015021-pol2qm74	3756	2	animals	animal	NNS
cord-015021-pol2qm74	3756	3	underwent	undergo	VBD
cord-015021-pol2qm74	3756	4	the	the	DT
cord-015021-pol2qm74	3756	5	same	same	JJ
cord-015021-pol2qm74	3756	6	procedures	procedure	NNS
cord-015021-pol2qm74	3756	7	,	,	,
cord-015021-pol2qm74	3756	8	but	but	CC
cord-015021-pol2qm74	3756	9	were	be	VBD
cord-015021-pol2qm74	3756	10	maintained	maintain	VBN
cord-015021-pol2qm74	3756	11	in	in	IN
cord-015021-pol2qm74	3756	12	normoxia	normoxia	NNP
cord-015021-pol2qm74	3756	13	(	(	-LRB-
cord-015021-pol2qm74	3756	14	21%O2	21%o2	CD
cord-015021-pol2qm74	3756	15	Disease	Disease	NNP
cord-015021-pol2qm74	3756	16	5	5	CD
cord-015021-pol2qm74	3756	17	,	,	,
cord-015021-pol2qm74	3756	18	Berlin	Berlin	NNP
cord-015021-pol2qm74	3756	19	,	,	,
cord-015021-pol2qm74	3756	20	Germany	Germany	NNP
cord-015021-pol2qm74	3757	1	The	the	DT
cord-015021-pol2qm74	3757	2	precise	precise	JJ
cord-015021-pol2qm74	3757	3	mechanisms	mechanism	NNS
cord-015021-pol2qm74	3757	4	of	of	IN
cord-015021-pol2qm74	3757	5	reactivation	reactivation	NN
cord-015021-pol2qm74	3757	6	of	of	IN
cord-015021-pol2qm74	3757	7	latent	latent	JJ
cord-015021-pol2qm74	3757	8	human	human	JJ
cord-015021-pol2qm74	3757	9	cytomegalovirus	cytomegalovirus	NN
cord-015021-pol2qm74	3757	10	(	(	-LRB-
cord-015021-pol2qm74	3757	11	CMV	CMV	NNP
cord-015021-pol2qm74	3757	12	)	)	-RRB-
cord-015021-pol2qm74	3757	13	infection	infection	NN
cord-015021-pol2qm74	3757	14	are	be	VBP
cord-015021-pol2qm74	3757	15	still	still	RB
cord-015021-pol2qm74	3757	16	unknown	unknown	JJ
cord-015021-pol2qm74	3757	17	.	.	.
cord-015021-pol2qm74	3758	1	Apart	apart	RB
cord-015021-pol2qm74	3758	2	from	from	IN
cord-015021-pol2qm74	3758	3	the	the	DT
cord-015021-pol2qm74	3758	4	permissive	permissive	JJ
cord-015021-pol2qm74	3758	5	effect	effect	NN
cord-015021-pol2qm74	3758	6	of	of	IN
cord-015021-pol2qm74	3758	7	diminished	diminish	VBN
cord-015021-pol2qm74	3758	8	cellular	cellular	JJ
cord-015021-pol2qm74	3758	9	immunity	immunity	NN
cord-015021-pol2qm74	3758	10	there	there	EX
cord-015021-pol2qm74	3758	11	is	be	VBZ
cord-015021-pol2qm74	3758	12	evidence	evidence	NN
cord-015021-pol2qm74	3758	13	of	of	IN
cord-015021-pol2qm74	3758	14	a	a	DT
cord-015021-pol2qm74	3758	15	cytokine	cytokine	NN
cord-015021-pol2qm74	3758	16	mediated	mediate	VBN
cord-015021-pol2qm74	3758	17	CMV	CMV	NNP
cord-015021-pol2qm74	3758	18	reactivation	reactivation	NN
cord-015021-pol2qm74	3758	19	as	as	IN
cord-015021-pol2qm74	3758	20	it	-PRON-	PRP
cord-015021-pol2qm74	3758	21	is	be	VBZ
cord-015021-pol2qm74	3758	22	known	know	VBN
cord-015021-pol2qm74	3758	23	for	for	IN
cord-015021-pol2qm74	3758	24	other	other	JJ
cord-015021-pol2qm74	3758	25	systemic	systemic	JJ
cord-015021-pol2qm74	3758	26	virus	virus	NN
cord-015021-pol2qm74	3758	27	infections	infection	NNS
cord-015021-pol2qm74	3758	28	(	(	-LRB-
cord-015021-pol2qm74	3758	29	e.g.	e.g.	IN
cord-015021-pol2qm74	3758	30	HIV	HIV	NNP
cord-015021-pol2qm74	3758	31	)	)	-RRB-
cord-015021-pol2qm74	3758	32	.	.	.
cord-015021-pol2qm74	3759	1	We	-PRON-	PRP
cord-015021-pol2qm74	3759	2	found	find	VBD
cord-015021-pol2qm74	3759	3	that	that	DT
cord-015021-pol2qm74	3759	4	tumor	tumor	NN
cord-015021-pol2qm74	3759	5	necrosis	necrosis	NN
cord-015021-pol2qm74	3759	6	factor	factor	NN
cord-015021-pol2qm74	3759	7	-	-	HYPH
cord-015021-pol2qm74	3759	8	alpha	alpha	NN
cord-015021-pol2qm74	3759	9	(	(	-LRB-
cord-015021-pol2qm74	3759	10	TNF	TNF	NNP
cord-015021-pol2qm74	3759	11	)	)	-RRB-
cord-015021-pol2qm74	3759	12	-in	-in	.
cord-015021-pol2qm74	3760	1	contrast	contrast	NN
cord-015021-pol2qm74	3760	2	to	to	IN
cord-015021-pol2qm74	3760	3	all	all	DT
cord-015021-pol2qm74	3760	4	other	other	JJ
cord-015021-pol2qm74	3760	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	3760	6	tested	test	VBD
cord-015021-pol2qm74	3760	7	-can	-can	TO
cord-015021-pol2qm74	3760	8	stimulate	stimulate	VBP
cord-015021-pol2qm74	3760	9	the	the	DT
cord-015021-pol2qm74	3760	10	activity	activity	NN
cord-015021-pol2qm74	3760	11	of	of	IN
cord-015021-pol2qm74	3760	12	the	the	DT
cord-015021-pol2qm74	3760	13	CMV	CMV	NNP
cord-015021-pol2qm74	3760	14	-	-	HYPH
cord-015021-pol2qm74	3760	15	IE	ie	NN
cord-015021-pol2qm74	3760	16	-	-	HYPH
cord-015021-pol2qm74	3760	17	enhancer	enhancer	NN
cord-015021-pol2qm74	3760	18	/	/	SYM
cord-015021-pol2qm74	3760	19	promoter	promoter	NN
cord-015021-pol2qm74	3760	20	region	region	NN
cord-015021-pol2qm74	3760	21	in	in	IN
cord-015021-pol2qm74	3760	22	the	the	DT
cord-015021-pol2qm74	3760	23	human	human	JJ
cord-015021-pol2qm74	3760	24	monocytic	monocytic	JJ
cord-015021-pol2qm74	3760	25	cell	cell	NN
cord-015021-pol2qm74	3760	26	line	line	NN
cord-015021-pol2qm74	3760	27	,	,	,
cord-015021-pol2qm74	3760	28	HL	HL	NNP
cord-015021-pol2qm74	3760	29	60	60	CD
cord-015021-pol2qm74	3760	30	.	.	.
cord-015021-pol2qm74	3761	1	We	-PRON-	PRP
cord-015021-pol2qm74	3761	2	wondered	wonder	VBD
cord-015021-pol2qm74	3761	3	whether	whether	IN
cord-015021-pol2qm74	3761	4	our	-PRON-	PRP$
cord-015021-pol2qm74	3761	5	in	in	FW
cord-015021-pol2qm74	3761	6	vitro	vitro	FW
cord-015021-pol2qm74	3761	7	results	result	NNS
cord-015021-pol2qm74	3761	8	were	be	VBD
cord-015021-pol2qm74	3761	9	actually	actually	RB
cord-015021-pol2qm74	3761	10	reflected	reflect	VBN
cord-015021-pol2qm74	3761	11	by	by	IN
cord-015021-pol2qm74	3761	12	the	the	DT
cord-015021-pol2qm74	3761	13	incidence	incidence	NN
cord-015021-pol2qm74	3761	14	of	of	IN
cord-015021-pol2qm74	3761	15	CMV	CMV	NNP
cord-015021-pol2qm74	3761	16	reactivation	reactivation	NN
cord-015021-pol2qm74	3761	17	in	in	IN
cord-015021-pol2qm74	3761	18	diseases	disease	NNS
cord-015021-pol2qm74	3761	19	which	which	WDT
cord-015021-pol2qm74	3761	20	go	go	VBP
cord-015021-pol2qm74	3761	21	together	together	RB
cord-015021-pol2qm74	3761	22	with	with	IN
cord-015021-pol2qm74	3761	23	high	high	JJ
cord-015021-pol2qm74	3761	24	TNFalpha	TNFalpha	NNS
cord-015021-pol2qm74	3761	25	levels	level	NNS
cord-015021-pol2qm74	3761	26	.	.	.
cord-015021-pol2qm74	3762	1	Cellular	cellular	JJ
cord-015021-pol2qm74	3762	2	immunodeficiency	immunodeficiency	NN
cord-015021-pol2qm74	3762	3	as	as	RB
cord-015021-pol2qm74	3762	4	well	well	RB
cord-015021-pol2qm74	3762	5	as	as	IN
cord-015021-pol2qm74	3762	6	at	at	IN
cord-015021-pol2qm74	3762	7	least	least	JJS
cord-015021-pol2qm74	3762	8	temporarily	temporarily	RB
cord-015021-pol2qm74	3762	9	increased	increase	VBN
cord-015021-pol2qm74	3762	10	TNF	TNF	NNP
cord-015021-pol2qm74	3762	11	levels	level	NNS
cord-015021-pol2qm74	3762	12	are	be	VBP
cord-015021-pol2qm74	3762	13	known	know	VBN
cord-015021-pol2qm74	3762	14	to	to	TO
cord-015021-pol2qm74	3762	15	occur	occur	VB
cord-015021-pol2qm74	3762	16	in	in	IN
cord-015021-pol2qm74	3762	17	septic	septic	JJ
cord-015021-pol2qm74	3762	18	disease	disease	NN
cord-015021-pol2qm74	3762	19	.	.	.
cord-015021-pol2qm74	3763	1	We	-PRON-	PRP
cord-015021-pol2qm74	3763	2	tested	test	VBD
cord-015021-pol2qm74	3763	3	for	for	IN
cord-015021-pol2qm74	3763	4	the	the	DT
cord-015021-pol2qm74	3763	5	presence	presence	NN
cord-015021-pol2qm74	3763	6	of	of	IN
cord-015021-pol2qm74	3763	7	CMV	CMV	NNP
cord-015021-pol2qm74	3763	8	infection	infection	NN
cord-015021-pol2qm74	3763	9	in	in	IN
cord-015021-pol2qm74	3763	10	peripheral	peripheral	JJ
cord-015021-pol2qm74	3763	11	blood	blood	NN
cord-015021-pol2qm74	3763	12	mononuclear	mononuclear	NN
cord-015021-pol2qm74	3763	13	cells	cell	NNS
cord-015021-pol2qm74	3763	14	(	(	-LRB-
cord-015021-pol2qm74	3763	15	PBMNC	PBMNC	NNP
cord-015021-pol2qm74	3763	16	)	)	-RRB-
cord-015021-pol2qm74	3763	17	by	by	IN
cord-015021-pol2qm74	3763	18	means	mean	NNS
cord-015021-pol2qm74	3763	19	of	of	IN
cord-015021-pol2qm74	3763	20	24h	24h	NNS
cord-015021-pol2qm74	3763	21	centrifugation	centrifugation	NN
cord-015021-pol2qm74	3763	22	culture	culture	NN
cord-015021-pol2qm74	3763	23	,	,	,
cord-015021-pol2qm74	3763	24	immunocytological	immunocytological	NNP
cord-015021-pol2qm74	3763	25	detection	detection	NN
cord-015021-pol2qm74	3763	26	of	of	IN
cord-015021-pol2qm74	3763	27	different	different	JJ
cord-015021-pol2qm74	3763	28	CMV	CMV	NNP
cord-015021-pol2qm74	3763	29	antigens	antigen	NNS
cord-015021-pol2qm74	3763	30	(	(	-LRB-
cord-015021-pol2qm74	3763	31	APAAP	APAAP	NNP
cord-015021-pol2qm74	3763	32	-	-	HYPH
cord-015021-pol2qm74	3763	33	technique	technique	NN
cord-015021-pol2qm74	3763	34	)	)	-RRB-
cord-015021-pol2qm74	3763	35	,	,	,
cord-015021-pol2qm74	3763	36	and	and	CC
cord-015021-pol2qm74	3763	37	PCR	PCR	NNP
cord-015021-pol2qm74	3763	38	technique	technique	NN
cord-015021-pol2qm74	3763	39	(	(	-LRB-
cord-015021-pol2qm74	3763	40	CMV	CMV	NNP
cord-015021-pol2qm74	3763	41	-	-	HYPH
cord-015021-pol2qm74	3763	42	IE	IE	NNP
cord-015021-pol2qm74	3763	43	DNA	DNA	NNP
cord-015021-pol2qm74	3763	44	)	)	-RRB-
cord-015021-pol2qm74	3763	45	.	.	.
cord-015021-pol2qm74	3764	1	In	in	IN
cord-015021-pol2qm74	3764	2	striking	striking	JJ
cord-015021-pol2qm74	3764	3	contrast	contrast	NN
cord-015021-pol2qm74	3764	4	to	to	IN
cord-015021-pol2qm74	3764	5	healthy	healthy	JJ
cord-015021-pol2qm74	3764	6	controls	control	NNS
cord-015021-pol2qm74	3764	7	almost	almost	RB
cord-015021-pol2qm74	3764	8	all	all	DT
cord-015021-pol2qm74	3764	9	examined	examine	VBD
cord-015021-pol2qm74	3764	10	septic	septic	JJ
cord-015021-pol2qm74	3764	11	patients	patient	NNS
cord-015021-pol2qm74	3764	12	were	be	VBD
cord-015021-pol2qm74	3764	13	positive	positive	JJ
cord-015021-pol2qm74	3764	14	,	,	,
cord-015021-pol2qm74	3764	15	irrespective	irrespective	RB
cord-015021-pol2qm74	3764	16	of	of	IN
cord-015021-pol2qm74	3764	17	the	the	DT
cord-015021-pol2qm74	3764	18	method	method	NN
cord-015021-pol2qm74	3764	19	for	for	IN
cord-015021-pol2qm74	3764	20	CMV	CMV	NNP
cord-015021-pol2qm74	3764	21	-	-	HYPH
cord-015021-pol2qm74	3764	22	ddtection	ddtection	NN
cord-015021-pol2qm74	3764	23	applied	apply	VBD
cord-015021-pol2qm74	3764	24	,	,	,
cord-015021-pol2qm74	3764	25	including	include	VBG
cord-015021-pol2qm74	3764	26	the	the	DT
cord-015021-pol2qm74	3764	27	less	less	RBR
cord-015021-pol2qm74	3764	28	sensitive	sensitive	JJ
cord-015021-pol2qm74	3764	29	immunocytology	immunocytology	NN
cord-015021-pol2qm74	3764	30	.	.	.
cord-015021-pol2qm74	3765	1	Follow	follow	VB
cord-015021-pol2qm74	3765	2	-	-	HYPH
cord-015021-pol2qm74	3765	3	up	up	RP
cord-015021-pol2qm74	3765	4	studies	study	NNS
cord-015021-pol2qm74	3765	5	showed	show	VBD
cord-015021-pol2qm74	3765	6	that	that	IN
cord-015021-pol2qm74	3765	7	CMV	CMV	NNP
cord-015021-pol2qm74	3765	8	-	-	HYPH
cord-015021-pol2qm74	3765	9	antigen	antigen	NN
cord-015021-pol2qm74	3765	10	positive	positive	JJ
cord-015021-pol2qm74	3765	11	PBMNC	PBMNC	NNS
cord-015021-pol2qm74	3765	12	ceased	cease	VBD
cord-015021-pol2qm74	3765	13	to	to	TO
cord-015021-pol2qm74	3765	14	be	be	VB
cord-015021-pol2qm74	3765	15	detectable	detectable	JJ
cord-015021-pol2qm74	3765	16	in	in	IN
cord-015021-pol2qm74	3765	17	patients	patient	NNS
cord-015021-pol2qm74	3765	18	with	with	IN
cord-015021-pol2qm74	3765	19	good	good	JJ
cord-015021-pol2qm74	3765	20	outcome	outcome	NN
cord-015021-pol2qm74	3765	21	once	once	IN
cord-015021-pol2qm74	3765	22	septicaemia	septicaemia	NN
cord-015021-pol2qm74	3765	23	had	have	VBD
cord-015021-pol2qm74	3765	24	been	be	VBN
cord-015021-pol2qm74	3765	25	overcome	overcome	VBN
cord-015021-pol2qm74	3765	26	.	.	.
cord-015021-pol2qm74	3766	1	To	to	TO
cord-015021-pol2qm74	3766	2	further	further	RB
cord-015021-pol2qm74	3766	3	back	back	VB
cord-015021-pol2qm74	3766	4	up	up	RP
cord-015021-pol2qm74	3766	5	our	-PRON-	PRP$
cord-015021-pol2qm74	3766	6	hypothesis	hypothesis	NN
cord-015021-pol2qm74	3766	7	,	,	,
cord-015021-pol2qm74	3766	8	we	-PRON-	PRP
cord-015021-pol2qm74	3766	9	looked	look	VBD
cord-015021-pol2qm74	3766	10	for	for	IN
cord-015021-pol2qm74	3766	11	a	a	DT
cord-015021-pol2qm74	3766	12	coincidence	coincidence	NN
cord-015021-pol2qm74	3766	13	of	of	IN
cord-015021-pol2qm74	3766	14	enhanced	enhance	VBN
cord-015021-pol2qm74	3766	15	TNF	TNF	NNP
cord-015021-pol2qm74	3766	16	-	-	HYPH
cord-015021-pol2qm74	3766	17	alpha	alpha	NN
cord-015021-pol2qm74	3766	18	serum	serum	NN
cord-015021-pol2qm74	3766	19	levels	level	NNS
cord-015021-pol2qm74	3766	20	and	and	CC
cord-015021-pol2qm74	3766	21	CMV	CMV	NNP
cord-015021-pol2qm74	3766	22	antigenaemia	antigenaemia	NN
cord-015021-pol2qm74	3766	23	(	(	-LRB-
cord-015021-pol2qm74	3766	24	immunocytology	immunocytology	NNP
cord-015021-pol2qm74	3766	25	)	)	-RRB-
cord-015021-pol2qm74	3766	26	in	in	IN
cord-015021-pol2qm74	3766	27	some	some	DT
cord-015021-pol2qm74	3766	28	other	other	JJ
cord-015021-pol2qm74	3766	29	diseases	disease	NNS
cord-015021-pol2qm74	3766	30	which	which	WDT
cord-015021-pol2qm74	3766	31	are	be	VBP
cord-015021-pol2qm74	3766	32	known	know	VBN
cord-015021-pol2qm74	3766	33	to	to	TO
cord-015021-pol2qm74	3766	34	have	have	VB
cord-015021-pol2qm74	3766	35	either	either	CC
cord-015021-pol2qm74	3766	36	enhanced	enhance	VBN
cord-015021-pol2qm74	3766	37	TNF	tnf	NN
cord-015021-pol2qm74	3766	38	serum	serum	NN
cord-015021-pol2qm74	3766	39	levels	level	NNS
cord-015021-pol2qm74	3766	40	or	or	CC
cord-015021-pol2qm74	3766	41	increased	increase	VBN
cord-015021-pol2qm74	3766	42	incidence	incidence	NN
cord-015021-pol2qm74	3766	43	of	of	IN
cord-015021-pol2qm74	3766	44	active	active	JJ
cord-015021-pol2qm74	3766	45	CMV	CMV	NNP
cord-015021-pol2qm74	3766	46	infection	infection	NN
cord-015021-pol2qm74	3766	47	and	and	CC
cord-015021-pol2qm74	3766	48	found	find	VBD
cord-015021-pol2qm74	3766	49	the	the	DT
cord-015021-pol2qm74	3766	50	majority	majority	NN
cord-015021-pol2qm74	3766	51	of	of	IN
cord-015021-pol2qm74	3766	52	patients	patient	NNS
cord-015021-pol2qm74	3766	53	with	with	IN
cord-015021-pol2qm74	3766	54	B	b	NN
cord-015021-pol2qm74	3766	55	-	-	HYPH
cord-015021-pol2qm74	3766	56	cell	cell	NN
cord-015021-pol2qm74	3766	57	chronic	chronic	NN
cord-015021-pol2qm74	3766	58	lymphocytic	lymphocytic	JJ
cord-015021-pol2qm74	3766	59	leukemia	leukemia	NN
cord-015021-pol2qm74	3766	60	,	,	,
cord-015021-pol2qm74	3766	61	liver	liver	NN
cord-015021-pol2qm74	3766	62	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	3766	63	,	,	,
cord-015021-pol2qm74	3766	64	and	and	CC
cord-015021-pol2qm74	3766	65	common	common	JJ
cord-015021-pol2qm74	3766	66	variable	variable	JJ
cord-015021-pol2qm74	3766	67	immunodeficiency	immunodeficiency	NN
cord-015021-pol2qm74	3766	68	to	to	TO
cord-015021-pol2qm74	3766	69	be	be	VB
cord-015021-pol2qm74	3766	70	positive	positive	JJ
cord-015021-pol2qm74	3766	71	for	for	IN
cord-015021-pol2qm74	3766	72	these	these	DT
cord-015021-pol2qm74	3766	73	two	two	CD
cord-015021-pol2qm74	3766	74	parameters	parameter	NNS
cord-015021-pol2qm74	3766	75	.	.	.
cord-015021-pol2qm74	3767	1	We	-PRON-	PRP
cord-015021-pol2qm74	3767	2	now	now	RB
cord-015021-pol2qm74	3767	3	wondered	wonder	VBD
cord-015021-pol2qm74	3767	4	whether	whether	IN
cord-015021-pol2qm74	3767	5	,	,	,
cord-015021-pol2qm74	3767	6	apart	apart	RB
cord-015021-pol2qm74	3767	7	from	from	IN
cord-015021-pol2qm74	3767	8	CMV	CMV	NNP
cord-015021-pol2qm74	3767	9	reactivation	reactivation	NN
cord-015021-pol2qm74	3767	10	,	,	,
cord-015021-pol2qm74	3767	11	TNF	tnf	NN
cord-015021-pol2qm74	3767	12	-	-	HYPH
cord-015021-pol2qm74	3767	13	alpha	alpha	NN
cord-015021-pol2qm74	3767	14	could	could	MD
cord-015021-pol2qm74	3767	15	also	also	RB
cord-015021-pol2qm74	3767	16	cause	cause	VB
cord-015021-pol2qm74	3767	17	cellular	cellular	JJ
cord-015021-pol2qm74	3767	18	immunodeficiency	immunodeficiency	NN
cord-015021-pol2qm74	3767	19	this	this	DT
cord-015021-pol2qm74	3767	20	way	way	NN
cord-015021-pol2qm74	3767	21	promoting	promote	VBG
cord-015021-pol2qm74	3767	22	CMV	CMV	NNP
cord-015021-pol2qm74	3767	23	replication	replication	NN
cord-015021-pol2qm74	3767	24	and	and	CC
cord-015021-pol2qm74	3767	25	spreading	spreading	NN
cord-015021-pol2qm74	3767	26	and	and	CC
cord-015021-pol2qm74	3767	27	eventually	eventually	RB
cord-015021-pol2qm74	3767	28	causing	cause	VBG
cord-015021-pol2qm74	3767	29	CMV	CMV	NNP
cord-015021-pol2qm74	3767	30	disease	disease	NN
cord-015021-pol2qm74	3767	31	.	.	.
cord-015021-pol2qm74	3768	1	In	in	IN
cord-015021-pol2qm74	3768	2	summary	summary	NN
cord-015021-pol2qm74	3768	3	,	,	,
cord-015021-pol2qm74	3768	4	we	-PRON-	PRP
cord-015021-pol2qm74	3768	5	were	be	VBD
cord-015021-pol2qm74	3768	6	able	able	JJ
cord-015021-pol2qm74	3768	7	to	to	TO
cord-015021-pol2qm74	3768	8	show	show	VB
cord-015021-pol2qm74	3768	9	that	that	IN
cord-015021-pol2qm74	3768	10	a	a	DT
cord-015021-pol2qm74	3768	11	diminished	diminished	JJ
cord-015021-pol2qm74	3768	12	cellular	cellular	JJ
cord-015021-pol2qm74	3768	13	immune	immune	JJ
cord-015021-pol2qm74	3768	14	response	response	NN
cord-015021-pol2qm74	3768	15	results	result	NNS
cord-015021-pol2qm74	3768	16	from	from	IN
cord-015021-pol2qm74	3768	17	/	/	SYM
cord-015021-pol2qm74	3768	18	n	n	CC
cord-015021-pol2qm74	3768	19	vitro	vitro	FW
cord-015021-pol2qm74	3768	20	or	or	CC
cord-015021-pol2qm74	3768	21	in	in	IN
cord-015021-pol2qm74	3768	22	vivo	vivo	NNP
cord-015021-pol2qm74	3768	23	Methylprednisolone	Methylprednisolone	NNP
cord-015021-pol2qm74	3768	24	(	(	-LRB-
cord-015021-pol2qm74	3768	25	MPS	MPS	NNP
cord-015021-pol2qm74	3768	26	)	)	-RRB-
cord-015021-pol2qm74	3768	27	is	be	VBZ
cord-015021-pol2qm74	3768	28	used	use	VBN
cord-015021-pol2qm74	3768	29	to	to	TO
cord-015021-pol2qm74	3768	30	suppress	suppress	VB
cord-015021-pol2qm74	3768	31	both	both	DT
cord-015021-pol2qm74	3768	32	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3768	33	and	and	CC
cord-015021-pol2qm74	3768	34	immune	immune	JJ
cord-015021-pol2qm74	3768	35	responses	response	NNS
cord-015021-pol2qm74	3768	36	.	.	.
cord-015021-pol2qm74	3769	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	3770	1	receptor	receptor	NN
cord-015021-pol2qm74	3770	2	antagonist	antagonist	NN
cord-015021-pol2qm74	3770	3	(	(	-LRB-
cord-015021-pol2qm74	3770	4	IL	IL	NNP
cord-015021-pol2qm74	3770	5	-	-	HYPH
cord-015021-pol2qm74	3770	6	lra	lra	NNP
cord-015021-pol2qm74	3770	7	)	)	-RRB-
cord-015021-pol2qm74	3770	8	and	and	CC
cord-015021-pol2qm74	3770	9	TNF	TNF	NNP
cord-015021-pol2qm74	3770	10	binding	bind	VBG
cord-015021-pol2qm74	3770	11	protein	protein	NN
cord-015021-pol2qm74	3770	12	(	(	-LRB-
cord-015021-pol2qm74	3770	13	TNFbp	TNFbp	NNP
cord-015021-pol2qm74	3770	14	)	)	-RRB-
cord-015021-pol2qm74	3770	15	are	be	VBP
cord-015021-pol2qm74	3770	16	naturally	naturally	RB
cord-015021-pol2qm74	3770	17	occuring	occur	VBG
cord-015021-pol2qm74	3770	18	anti	anti	JJ
cord-015021-pol2qm74	3770	19	-	-	JJ
cord-015021-pol2qm74	3770	20	cytokine	cytokine	JJ
cord-015021-pol2qm74	3770	21	proteins	protein	NNS
cord-015021-pol2qm74	3770	22	,	,	,
cord-015021-pol2qm74	3770	23	possibly	possibly	RB
cord-015021-pol2qm74	3770	24	modulating	modulate	VBG
cord-015021-pol2qm74	3770	25	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3770	26	and	and	CC
cord-015021-pol2qm74	3770	27	immunological	immunological	JJ
cord-015021-pol2qm74	3770	28	responses	response	NNS
cord-015021-pol2qm74	3770	29	.	.	.
cord-015021-pol2qm74	3771	1	To	to	TO
cord-015021-pol2qm74	3771	2	define	define	VB
cord-015021-pol2qm74	3771	3	MPS	MPS	NNP
cord-015021-pol2qm74	3771	4	modulation	modulation	NN
cord-015021-pol2qm74	3771	5	of	of	IN
cord-015021-pol2qm74	3771	6	cytokine	cytokine	NN
cord-015021-pol2qm74	3771	7	and	and	CC
cord-015021-pol2qm74	3771	8	anticytokine	anticytokine	JJ
cord-015021-pol2qm74	3771	9	responses	response	NNS
cord-015021-pol2qm74	3771	10	,	,	,
cord-015021-pol2qm74	3771	11	we	-PRON-	PRP
cord-015021-pol2qm74	3771	12	examined	examine	VBD
cord-015021-pol2qm74	3771	13	effects	effect	NNS
cord-015021-pol2qm74	3771	14	of	of	IN
cord-015021-pol2qm74	3771	15	MPS	MPS	NNP
cord-015021-pol2qm74	3771	16	on	on	IN
cord-015021-pol2qm74	3771	17	IL	IL	NNP
cord-015021-pol2qm74	3771	18	-	-	HYPH
cord-015021-pol2qm74	3771	19	lra	lra	NNP
cord-015021-pol2qm74	3771	20	production	production	NN
cord-015021-pol2qm74	3771	21	and	and	CC
cord-015021-pol2qm74	3771	22	TNFbp	TNFbp	NNP
cord-015021-pol2qm74	3771	23	generation	generation	NN
cord-015021-pol2qm74	3771	24	as	as	RB
cord-015021-pol2qm74	3771	25	well	well	RB
cord-015021-pol2qm74	3771	26	as	as	IN
cord-015021-pol2qm74	3772	1	IL	IL	NNP
cord-015021-pol2qm74	3772	2	-	-	HYPH
cord-015021-pol2qm74	3772	3	I~	I~	NNP
cord-015021-pol2qm74	3772	4	and	and	CC
cord-015021-pol2qm74	3772	5	TNFa	TNFa	NNP
cord-015021-pol2qm74	3772	6	production	production	NN
cord-015021-pol2qm74	3772	7	by	by	IN
cord-015021-pol2qm74	3772	8	human	human	JJ
cord-015021-pol2qm74	3772	9	peripheral	peripheral	JJ
cord-015021-pol2qm74	3772	10	blood	blood	NN
cord-015021-pol2qm74	3772	11	mononuclear	mononuclear	NN
cord-015021-pol2qm74	3772	12	cells	cell	NNS
cord-015021-pol2qm74	3772	13	(	(	-LRB-
cord-015021-pol2qm74	3772	14	PBMC	PBMC	NNP
cord-015021-pol2qm74	3772	15	)	)	-RRB-
cord-015021-pol2qm74	3772	16	stimulated	stimulate	VBD
cord-015021-pol2qm74	3772	17	with	with	IN
cord-015021-pol2qm74	3772	18	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3772	19	(	(	-LRB-
cord-015021-pol2qm74	3772	20	LPS	LPS	NNP
cord-015021-pol2qm74	3772	21	)	)	-RRB-
cord-015021-pol2qm74	3772	22	.	.	.
cord-015021-pol2qm74	3773	1	PBMC	PBMC	NNS
cord-015021-pol2qm74	3773	2	were	be	VBD
cord-015021-pol2qm74	3773	3	purified	purify	VBN
cord-015021-pol2qm74	3773	4	from	from	IN
cord-015021-pol2qm74	3773	5	the	the	DT
cord-015021-pol2qm74	3773	6	blood	blood	NN
cord-015021-pol2qm74	3773	7	of	of	IN
cord-015021-pol2qm74	3773	8	healthy	healthy	JJ
cord-015021-pol2qm74	3773	9	volunteers	volunteer	NNS
cord-015021-pol2qm74	3773	10	,	,	,
cord-015021-pol2qm74	3773	11	then	then	RB
cord-015021-pol2qm74	3773	12	incubated	incubate	VBN
cord-015021-pol2qm74	3773	13	with	with	IN
cord-015021-pol2qm74	3773	14	LPS	LPS	NNP
cord-015021-pol2qm74	3773	15	(	(	-LRB-
cord-015021-pol2qm74	3773	16	10ng	10ng	NNP
cord-015021-pol2qm74	3773	17	/	/	SYM
cord-015021-pol2qm74	3773	18	ml	ml	NN
cord-015021-pol2qm74	3773	19	)	)	-RRB-
cord-015021-pol2qm74	3773	20	supplemented	supplement	VBN
cord-015021-pol2qm74	3773	21	with	with	IN
cord-015021-pol2qm74	3773	22	different	different	JJ
cord-015021-pol2qm74	3773	23	concentrations	concentration	NNS
cord-015021-pol2qm74	3773	24	of	of	IN
cord-015021-pol2qm74	3773	25	MPS	MPS	NNP
cord-015021-pol2qm74	3773	26	(	(	-LRB-
cord-015021-pol2qm74	3773	27	0	0	NFP
cord-015021-pol2qm74	3773	28	,	,	,
cord-015021-pol2qm74	3773	29	500pg	500pg	NNP
cord-015021-pol2qm74	3773	30	/	/	SYM
cord-015021-pol2qm74	3773	31	ml	ml	NN
cord-015021-pol2qm74	3773	32	,	,	,
cord-015021-pol2qm74	3773	33	50mg	50mg	NNP
cord-015021-pol2qm74	3773	34	/	/	SYM
cord-015021-pol2qm74	3773	35	ml	ml	NN
cord-015021-pol2qm74	3773	36	)	)	-RRB-
cord-015021-pol2qm74	3773	37	.	.	.
cord-015021-pol2qm74	3774	1	After	after	IN
cord-015021-pol2qm74	3774	2	24hrs	24hrs	NN
cord-015021-pol2qm74	3774	3	incubation	incubation	NN
cord-015021-pol2qm74	3774	4	,	,	,
cord-015021-pol2qm74	3774	5	the	the	DT
cord-015021-pol2qm74	3774	6	supernatants	supernatant	NNS
cord-015021-pol2qm74	3774	7	were	be	VBD
cord-015021-pol2qm74	3774	8	collected	collect	VBN
cord-015021-pol2qm74	3774	9	for	for	IN
cord-015021-pol2qm74	3774	10	RIAs	ria	NNS
cord-015021-pol2qm74	3774	11	of	of	IN
cord-015021-pol2qm74	3774	12	secreted	secrete	VBN
cord-015021-pol2qm74	3774	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	3774	14	.	.	.
cord-015021-pol2qm74	3775	1	The	the	DT
cord-015021-pol2qm74	3775	2	cell	cell	NN
cord-015021-pol2qm74	3775	3	lysates	lysate	NNS
cord-015021-pol2qm74	3775	4	obtained	obtain	VBN
cord-015021-pol2qm74	3775	5	by	by	IN
cord-015021-pol2qm74	3775	6	3	3	CD
cord-015021-pol2qm74	3775	7	cycles	cycle	NNS
cord-015021-pol2qm74	3775	8	of	of	IN
cord-015021-pol2qm74	3775	9	freeze	freeze	NN
cord-015021-pol2qm74	3775	10	-	-	HYPH
cord-015021-pol2qm74	3775	11	thaw	thaw	NN
cord-015021-pol2qm74	3775	12	,	,	,
cord-015021-pol2qm74	3775	13	were	be	VBD
cord-015021-pol2qm74	3775	14	also	also	RB
cord-015021-pol2qm74	3775	15	collected	collect	VBN
cord-015021-pol2qm74	3775	16	for	for	IN
cord-015021-pol2qm74	3775	17	R	r	NN
cord-015021-pol2qm74	3775	18	IAs	ias	NN
cord-015021-pol2qm74	3775	19	of	of	IN
cord-015021-pol2qm74	3775	20	cell	cell	NN
cord-015021-pol2qm74	3775	21	-	-	HYPH
cord-015021-pol2qm74	3775	22	associated	associate	VBN
cord-015021-pol2qm74	3775	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	3775	24	.	.	.
cord-015021-pol2qm74	3776	1	Both	both	DT
cord-015021-pol2qm74	3776	2	the	the	DT
cord-015021-pol2qm74	3776	3	supernatant	supernatant	NN
cord-015021-pol2qm74	3776	4	for	for	IN
cord-015021-pol2qm74	3776	5	secreted	secrete	VBN
cord-015021-pol2qm74	3776	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	3776	7	and	and	CC
cord-015021-pol2qm74	3776	8	the	the	DT
cord-015021-pol2qm74	3776	9	cell	cell	NN
cord-015021-pol2qm74	3776	10	lysates	lysate	NNS
cord-015021-pol2qm74	3776	11	for	for	IN
cord-015021-pol2qm74	3776	12	the	the	DT
cord-015021-pol2qm74	3776	13	cell	cell	NN
cord-015021-pol2qm74	3776	14	-	-	HYPH
cord-015021-pol2qm74	3776	15	associated	associate	VBN
cord-015021-pol2qm74	3776	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	3776	17	were	be	VBD
cord-015021-pol2qm74	3776	18	subjected	subject	VBN
cord-015021-pol2qm74	3776	19	to	to	IN
cord-015021-pol2qm74	3776	20	RIAs	RIAs	NNP
cord-015021-pol2qm74	3776	21	for	for	IN
cord-015021-pol2qm74	3776	22	IL	IL	NNP
cord-015021-pol2qm74	3776	23	-	-	HYPH
cord-015021-pol2qm74	3776	24	I~	I~	NNP
cord-015021-pol2qm74	3776	25	,	,	,
cord-015021-pol2qm74	3776	26	TNFa	TNFa	NNP
cord-015021-pol2qm74	3776	27	,	,	,
cord-015021-pol2qm74	3776	28	IL-1	IL-1	NNP
cord-015021-pol2qm74	3776	29	ra	ra	NNP
cord-015021-pol2qm74	3776	30	,	,	,
cord-015021-pol2qm74	3776	31	and	and	CC
cord-015021-pol2qm74	3776	32	TNFbp	TNFbp	NNP
cord-015021-pol2qm74	3776	33	-	-	HYPH
cord-015021-pol2qm74	3776	34	I	I	NNP
cord-015021-pol2qm74	3776	35	(	(	-LRB-
cord-015021-pol2qm74	3776	36	TNFsRp55	tnfsrp55	NN
cord-015021-pol2qm74	3776	37	)	)	-RRB-
cord-015021-pol2qm74	3776	38	.	.	.
cord-015021-pol2qm74	3777	1	IL	IL	NNP
cord-015021-pol2qm74	3777	2	-	-	HYPH
cord-015021-pol2qm74	3777	3	la	la	NNP
cord-015021-pol2qm74	3777	4	,	,	,
cord-015021-pol2qm74	3777	5	IL-1	IL-1	NNP
cord-015021-pol2qm74	3777	6	ra	ra	NNP
cord-015021-pol2qm74	3777	7	,	,	,
cord-015021-pol2qm74	3777	8	and	and	CC
cord-015021-pol2qm74	3777	9	TNFbp	TNFbp	NNP
cord-015021-pol2qm74	3777	10	were	be	VBD
cord-015021-pol2qm74	3777	11	produced	produce	VBN
cord-015021-pol2qm74	3777	12	mainly	mainly	RB
cord-015021-pol2qm74	3777	13	as	as	IN
cord-015021-pol2qm74	3777	14	cell	cell	NN
cord-015021-pol2qm74	3777	15	-	-	HYPH
cord-015021-pol2qm74	3777	16	associated	associate	VBN
cord-015021-pol2qm74	3777	17	forms	form	NNS
cord-015021-pol2qm74	3777	18	in	in	IN
cord-015021-pol2qm74	3777	19	response	response	NN
cord-015021-pol2qm74	3777	20	to	to	IN
cord-015021-pol2qm74	3777	21	LPS	LPS	NNP
cord-015021-pol2qm74	3777	22	,	,	,
cord-015021-pol2qm74	3777	23	whereas	whereas	IN
cord-015021-pol2qm74	3777	24	most	most	JJS
cord-015021-pol2qm74	3777	25	TNFa	TNFa	NNS
cord-015021-pol2qm74	3777	26	was	be	VBD
cord-015021-pol2qm74	3777	27	secreted	secrete	VBN
cord-015021-pol2qm74	3777	28	into	into	IN
cord-015021-pol2qm74	3777	29	the	the	DT
cord-015021-pol2qm74	3777	30	supernatant	supernatant	NN
cord-015021-pol2qm74	3777	31	of	of	IN
cord-015021-pol2qm74	3777	32	LPS	LPS	NNP
cord-015021-pol2qm74	3777	33	-	-	HYPH
cord-015021-pol2qm74	3777	34	stimulated	stimulate	VBN
cord-015021-pol2qm74	3777	35	PBMC	PBMC	NNS
cord-015021-pol2qm74	3777	36	.	.	.
cord-015021-pol2qm74	3778	1	MPS	MPS	NNP
cord-015021-pol2qm74	3778	2	supplement	supplement	NN
cord-015021-pol2qm74	3778	3	resulted	result	VBD
cord-015021-pol2qm74	3778	4	in	in	IN
cord-015021-pol2qm74	3778	5	reduction	reduction	NN
cord-015021-pol2qm74	3778	6	of	of	IN
cord-015021-pol2qm74	3778	7	IL	IL	NNP
cord-015021-pol2qm74	3778	8	-	-	HYPH
cord-015021-pol2qm74	3778	9	la	la	NNP
cord-015021-pol2qm74	3778	10	,	,	,
cord-015021-pol2qm74	3778	11	IL	IL	NNP
cord-015021-pol2qm74	3778	12	-	-	HYPH
cord-015021-pol2qm74	3778	13	lra	lra	NNP
cord-015021-pol2qm74	3778	14	,	,	,
cord-015021-pol2qm74	3778	15	and	and	CC
cord-015021-pol2qm74	3778	16	TNFa	TNFa	NNP
cord-015021-pol2qm74	3778	17	production	production	NN
cord-015021-pol2qm74	3778	18	.	.	.
cord-015021-pol2qm74	3779	1	IL	IL	NNP
cord-015021-pol2qm74	3779	2	-	-	HYPH
cord-015021-pol2qm74	3779	3	la	la	JJ
cord-015021-pol2qm74	3779	4	production	production	NN
cord-015021-pol2qm74	3779	5	was	be	VBD
cord-015021-pol2qm74	3779	6	reduced	reduce	VBN
cord-015021-pol2qm74	3779	7	up	up	IN
cord-015021-pol2qm74	3779	8	to	to	IN
cord-015021-pol2qm74	3779	9	5.4	5.4	CD
cord-015021-pol2qm74	3779	10	+	+	CD
cord-015021-pol2qm74	3779	11	1.6%(50mg	1.6%(50mg	CD
cord-015021-pol2qm74	3779	12	/	/	SYM
cord-015021-pol2qm74	3779	13	ml	ml	NN
cord-015021-pol2qm74	3779	14	)	)	-RRB-
cord-015021-pol2qm74	3779	15	by	by	IN
cord-015021-pol2qm74	3779	16	MPS	MPS	NNP
cord-015021-pol2qm74	3779	17	in	in	IN
cord-015021-pol2qm74	3779	18	a	a	DT
cord-015021-pol2qm74	3779	19	dose	dose	JJ
cord-015021-pol2qm74	3779	20	dependent	dependent	JJ
cord-015021-pol2qm74	3779	21	fashion	fashion	NN
cord-015021-pol2qm74	3779	22	,	,	,
cord-015021-pol2qm74	3779	23	whereas	whereas	IN
cord-015021-pol2qm74	3779	24	about	about	RB
cord-015021-pol2qm74	3779	25	50	50	CD
cord-015021-pol2qm74	3779	26	%	%	NN
cord-015021-pol2qm74	3779	27	decrease	decrease	NN
cord-015021-pol2qm74	3779	28	in	in	IN
cord-015021-pol2qm74	3779	29	TNFc	TNFc	NNS
cord-015021-pol2qm74	3779	30	,	,	,
cord-015021-pol2qm74	3779	31	and	and	CC
cord-015021-pol2qm74	3779	32	IL	IL	NNP
cord-015021-pol2qm74	3779	33	-	-	HYPH
cord-015021-pol2qm74	3779	34	lra	lra	NNP
cord-015021-pol2qm74	3779	35	production	production	NN
cord-015021-pol2qm74	3779	36	was	be	VBD
cord-015021-pol2qm74	3779	37	observed	observe	VBN
cord-015021-pol2qm74	3779	38	at	at	IN
cord-015021-pol2qm74	3779	39	both	both	CC
cord-015021-pol2qm74	3779	40	high	high	JJ
cord-015021-pol2qm74	3779	41	and	and	CC
cord-015021-pol2qm74	3779	42	low	low	JJ
cord-015021-pol2qm74	3779	43	dose	dose	NN
cord-015021-pol2qm74	3779	44	MPS	MPS	NNP
cord-015021-pol2qm74	3779	45	supplement	supplement	NN
cord-015021-pol2qm74	3779	46	.	.	.
cord-015021-pol2qm74	3780	1	However	however	RB
cord-015021-pol2qm74	3780	2	,	,	,
cord-015021-pol2qm74	3780	3	total	total	JJ
cord-015021-pol2qm74	3780	4	TNFbp	TNFbp	NNP
cord-015021-pol2qm74	3780	5	generation	generation	NN
cord-015021-pol2qm74	3780	6	was	be	VBD
cord-015021-pol2qm74	3780	7	not	not	RB
cord-015021-pol2qm74	3780	8	reduced	reduce	VBN
cord-015021-pol2qm74	3780	9	significantly	significantly	RB
cord-015021-pol2qm74	3780	10	by	by	IN
cord-015021-pol2qm74	3780	11	MPS	MPS	NNP
cord-015021-pol2qm74	3780	12	supplement	supplement	NN
cord-015021-pol2qm74	3780	13	.	.	.
cord-015021-pol2qm74	3781	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	3781	2	,	,	,
cord-015021-pol2qm74	3781	3	TNFbp	TNFbp	NNP
cord-015021-pol2qm74	3781	4	secretion	secretion	NN
cord-015021-pol2qm74	3781	5	was	be	VBD
cord-015021-pol2qm74	3781	6	increased	increase	VBN
cord-015021-pol2qm74	3781	7	12	12	CD
cord-015021-pol2qm74	3781	8	times	time	NNS
cord-015021-pol2qm74	3781	9	more	more	JJR
cord-015021-pol2qm74	3781	10	in	in	IN
cord-015021-pol2qm74	3781	11	the	the	DT
cord-015021-pol2qm74	3781	12	supernatant	supernatant	NN
cord-015021-pol2qm74	3781	13	of	of	IN
cord-015021-pol2qm74	3781	14	LPS	LPS	NNP
cord-015021-pol2qm74	3781	15	-	-	HYPH
cord-015021-pol2qm74	3781	16	stimulated	stimulate	VBN
cord-015021-pol2qm74	3781	17	PBMC	PBMC	NNP
cord-015021-pol2qm74	3781	18	with	with	IN
cord-015021-pol2qm74	3781	19	500gg	500gg	NN
cord-015021-pol2qm74	3781	20	/	/	SYM
cord-015021-pol2qm74	3781	21	ml	ml	NN
cord-015021-pol2qm74	3781	22	of	of	IN
cord-015021-pol2qm74	3781	23	MPS	MPS	NNP
cord-015021-pol2qm74	3781	24	.	.	.
cord-015021-pol2qm74	3782	1	These	these	DT
cord-015021-pol2qm74	3782	2	data	datum	NNS
cord-015021-pol2qm74	3782	3	suggest	suggest	VBP
cord-015021-pol2qm74	3782	4	that	that	IN
cord-015021-pol2qm74	3782	5	MPS	MPS	NNP
cord-015021-pol2qm74	3782	6	could	could	MD
cord-015021-pol2qm74	3782	7	effectively	effectively	RB
cord-015021-pol2qm74	3782	8	block	block	VB
cord-015021-pol2qm74	3782	9	TNF	tnf	NN
cord-015021-pol2qm74	3782	10	activity	activity	NN
cord-015021-pol2qm74	3782	11	by	by	IN
cord-015021-pol2qm74	3782	12	both	both	DT
cord-015021-pol2qm74	3782	13	reducing	reduce	VBG
cord-015021-pol2qm74	3782	14	its	-PRON-	PRP$
cord-015021-pol2qm74	3782	15	production	production	NN
cord-015021-pol2qm74	3782	16	and	and	CC
cord-015021-pol2qm74	3782	17	up	up	RB
cord-015021-pol2qm74	3782	18	-	-	HYPH
cord-015021-pol2qm74	3782	19	regulating	regulate	VBG
cord-015021-pol2qm74	3782	20	TNFbp	TNFbp	NNP
cord-015021-pol2qm74	3782	21	generation	generation	NN
cord-015021-pol2qm74	3782	22	and	and	CC
cord-015021-pol2qm74	3782	23	that	that	IN
cord-015021-pol2qm74	3782	24	MPS	MPS	NNP
cord-015021-pol2qm74	3782	25	works	work	VBZ
cord-015021-pol2qm74	3782	26	as	as	IN
cord-015021-pol2qm74	3782	27	an	an	DT
cord-015021-pol2qm74	3782	28	anti	anti	JJ
cord-015021-pol2qm74	3782	29	-	-	JJ
cord-015021-pol2qm74	3782	30	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3782	31	drug	drug	NN
cord-015021-pol2qm74	3782	32	as	as	RB
cord-015021-pol2qm74	3782	33	well	well	RB
cord-015021-pol2qm74	3782	34	as	as	IN
cord-015021-pol2qm74	3782	35	an	an	DT
cord-015021-pol2qm74	3782	36	immunosuppressant	immunosuppressant	NN
cord-015021-pol2qm74	3782	37	by	by	IN
cord-015021-pol2qm74	3782	38	modulating	modulate	VBG
cord-015021-pol2qm74	3782	39	cytokine	cytokine	NN
cord-015021-pol2qm74	3782	40	and	and	CC
cord-015021-pol2qm74	3782	41	anticytokine	anticytokine	JJ
cord-015021-pol2qm74	3782	42	responses	response	NNS
cord-015021-pol2qm74	3782	43	.	.	.
cord-015021-pol2qm74	3783	1	In	in	IN
cord-015021-pol2qm74	3783	2	severe	severe	JJ
cord-015021-pol2qm74	3783	3	gram	gram	NN
cord-015021-pol2qm74	3783	4	-	-	HYPH
cord-015021-pol2qm74	3783	5	negative	negative	JJ
cord-015021-pol2qm74	3783	6	sepsis	sepsis	NN
cord-015021-pol2qm74	3783	7	,	,	,
cord-015021-pol2qm74	3783	8	excess	excess	NN
cord-015021-pol2qm74	3783	9	of	of	IN
cord-015021-pol2qm74	3783	10	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3783	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	3783	12	is	be	VBZ
cord-015021-pol2qm74	3783	13	associated	associate	VBN
cord-015021-pol2qm74	3783	14	with	with	IN
cord-015021-pol2qm74	3783	15	increased	increase	VBN
cord-015021-pol2qm74	3783	16	morbidity	morbidity	NN
cord-015021-pol2qm74	3783	17	and	and	CC
cord-015021-pol2qm74	3783	18	the	the	DT
cord-015021-pol2qm74	3783	19	mortality	mortality	NN
cord-015021-pol2qm74	3783	20	.	.	.
cord-015021-pol2qm74	3784	1	We	-PRON-	PRP
cord-015021-pol2qm74	3784	2	have	have	VBP
cord-015021-pol2qm74	3784	3	found	find	VBN
cord-015021-pol2qm74	3784	4	that	that	IN
cord-015021-pol2qm74	3784	5	immunocytes	immunocyte	NNS
cord-015021-pol2qm74	3784	6	possess	possess	VBP
cord-015021-pol2qm74	3784	7	functional	functional	JJ
cord-015021-pol2qm74	3784	8	13-adrenergic	13-adrenergic	CD
cord-015021-pol2qm74	3784	9	receptors	receptor	NNS
cord-015021-pol2qm74	3784	10	(	(	-LRB-
cord-015021-pol2qm74	3784	11	~-AR	~-AR	NFP
cord-015021-pol2qm74	3784	12	)	)	-RRB-
cord-015021-pol2qm74	3784	13	which	which	WDT
cord-015021-pol2qm74	3784	14	,	,	,
cord-015021-pol2qm74	3784	15	when	when	WRB
cord-015021-pol2qm74	3784	16	activated	activate	VBN
cord-015021-pol2qm74	3784	17	,	,	,
cord-015021-pol2qm74	3784	18	down	down	RB
cord-015021-pol2qm74	3784	19	regulate	regulate	VB
cord-015021-pol2qm74	3784	20	the	the	DT
cord-015021-pol2qm74	3784	21	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	3784	22	(	(	-LRB-
cord-015021-pol2qm74	3784	23	LPS	LPS	NNP
cord-015021-pol2qm74	3784	24	)	)	-RRB-
cord-015021-pol2qm74	3784	25	induced	induce	VBN
cord-015021-pol2qm74	3784	26	gene	gene	NN
cord-015021-pol2qm74	3784	27	expression	expression	NN
cord-015021-pol2qm74	3784	28	and	and	CC
cord-015021-pol2qm74	3784	29	subsequent	subsequent	JJ
cord-015021-pol2qm74	3784	30	secretion	secretion	NN
cord-015021-pol2qm74	3784	31	of	of	IN
cord-015021-pol2qm74	3784	32	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	3784	33	in	in	IN
cord-015021-pol2qm74	3784	34	vitro	vitro	FW
cord-015021-pol2qm74	3784	35	.	.	.
cord-015021-pol2qm74	3785	1	In	in	IN
cord-015021-pol2qm74	3785	2	the	the	DT
cord-015021-pol2qm74	3785	3	present	present	JJ
cord-015021-pol2qm74	3785	4	study	study	NN
cord-015021-pol2qm74	3785	5	,	,	,
cord-015021-pol2qm74	3785	6	we	-PRON-	PRP
cord-015021-pol2qm74	3785	7	used	use	VBD
cord-015021-pol2qm74	3785	8	a	a	DT
cord-015021-pol2qm74	3785	9	lethal	lethal	JJ
cord-015021-pol2qm74	3785	10	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	3785	11	model	model	NN
cord-015021-pol2qm74	3785	12	in	in	IN
cord-015021-pol2qm74	3785	13	mice	mouse	NNS
cord-015021-pol2qm74	3785	14	to	to	TO
cord-015021-pol2qm74	3785	15	test	test	VB
cord-015021-pol2qm74	3785	16	the	the	DT
cord-015021-pol2qm74	3785	17	hypothesis	hypothesis	NN
cord-015021-pol2qm74	3785	18	that	that	IN
cord-015021-pol2qm74	3785	19	13-AR	13-ar	CD
cord-015021-pol2qm74	3785	20	stimulation	stimulation	NN
cord-015021-pol2qm74	3785	21	will	will	MD
cord-015021-pol2qm74	3785	22	down	down	RB
cord-015021-pol2qm74	3785	23	regulate	regulate	VB
cord-015021-pol2qm74	3785	24	the	the	DT
cord-015021-pol2qm74	3785	25	gene	gene	NN
cord-015021-pol2qm74	3785	26	expression	expression	NN
cord-015021-pol2qm74	3785	27	thus	thus	RB
cord-015021-pol2qm74	3785	28	decreasing	decrease	VBG
cord-015021-pol2qm74	3785	29	the	the	DT
cord-015021-pol2qm74	3785	30	circulatory	circulatory	JJ
cord-015021-pol2qm74	3785	31	levels	level	NNS
cord-015021-pol2qm74	3785	32	of	of	IN
cord-015021-pol2qm74	3785	33	proinftammatory	proinftammatory	NN
cord-015021-pol2qm74	3785	34	cytokines	cytokine	NNS
cord-015021-pol2qm74	3785	35	and	and	CC
cord-015021-pol2qm74	3785	36	improve	improve	VB
cord-015021-pol2qm74	3785	37	the	the	DT
cord-015021-pol2qm74	3785	38	survivals	survival	NNS
cord-015021-pol2qm74	3785	39	in	in	IN
cord-015021-pol2qm74	3785	40	severe	severe	JJ
cord-015021-pol2qm74	3785	41	endotoxicosis	endotoxicosis	NN
cord-015021-pol2qm74	3785	42	.	.	.
cord-015021-pol2qm74	3786	1	The	the	DT
cord-015021-pol2qm74	3786	2	animals	animal	NNS
cord-015021-pol2qm74	3786	3	(	(	-LRB-
cord-015021-pol2qm74	3786	4	ISO	iso	NN
cord-015021-pol2qm74	3786	5	group	group	NN
cord-015021-pol2qm74	3786	6	)	)	-RRB-
cord-015021-pol2qm74	3786	7	were	be	VBD
cord-015021-pol2qm74	3786	8	injected	inject	VBN
cord-015021-pol2qm74	3786	9	3	3	CD
cord-015021-pol2qm74	3786	10	times	time	NNS
cord-015021-pol2qm74	3786	11	with	with	IN
cord-015021-pol2qm74	3786	12	!	!	.
cord-015021-pol2qm74	3787	1	3-AR	3-ar	CD
cord-015021-pol2qm74	3787	2	agohist	agohist	NNP
cord-015021-pol2qm74	3787	3	isoproterenol	isoproterenol	NNP
cord-015021-pol2qm74	3787	4	(	(	-LRB-
cord-015021-pol2qm74	3788	1	0.5	0.5	CD
cord-015021-pol2qm74	3788	2	mg	mg	NNP
cord-015021-pol2qm74	3788	3	/	/	SYM
cord-015021-pol2qm74	3788	4	kg	kg	NNP
cord-015021-pol2qm74	3788	5	i.m	i.m	NNP
cord-015021-pol2qm74	3788	6	.	.	.
cord-015021-pol2qm74	3789	1	and	and	CC
cord-015021-pol2qm74	3789	2	0.5	0.5	CD
cord-015021-pol2qm74	3789	3	mg	mg	NNP
cord-015021-pol2qm74	3789	4	/	/	SYM
cord-015021-pol2qm74	3789	5	kg	kg	NNP
cord-015021-pol2qm74	3789	6	s.c	s.c	NNP
cord-015021-pol2qm74	3789	7	.	.	NNP
cord-015021-pol2qm74	3789	8	)	)	-RRB-
cord-015021-pol2qm74	3789	9	4	4	CD
cord-015021-pol2qm74	3789	10	,	,	,
cord-015021-pol2qm74	3789	11	2	2	CD
cord-015021-pol2qm74	3789	12	and	and	CC
cord-015021-pol2qm74	3789	13	0	0	CD
cord-015021-pol2qm74	3789	14	hours	hour	NNS
cord-015021-pol2qm74	3789	15	prior	prior	RB
cord-015021-pol2qm74	3789	16	to	to	IN
cord-015021-pol2qm74	3789	17	a	a	DT
cord-015021-pol2qm74	3789	18	lethal	lethal	JJ
cord-015021-pol2qm74	3789	19	dose	dose	NN
cord-015021-pol2qm74	3789	20	of	of	IN
cord-015021-pol2qm74	3789	21	LPS	LPS	NNP
cord-015021-pol2qm74	3789	22	injection	injection	NN
cord-015021-pol2qm74	3789	23	(	(	-LRB-
cord-015021-pol2qm74	3789	24	25	25	CD
cord-015021-pol2qm74	3789	25	mg	mg	NNP
cord-015021-pol2qm74	3789	26	/	/	SYM
cord-015021-pol2qm74	3789	27	kg	kg	NNP
cord-015021-pol2qm74	3789	28	i.p	i.p	NNP
cord-015021-pol2qm74	3789	29	.	.	NNP
cord-015021-pol2qm74	3789	30	)	)	-RRB-
cord-015021-pol2qm74	3789	31	.	.	.
cord-015021-pol2qm74	3790	1	Control	control	NN
cord-015021-pol2qm74	3790	2	group	group	NN
cord-015021-pol2qm74	3790	3	(	(	-LRB-
cord-015021-pol2qm74	3790	4	CTL	CTL	NNP
cord-015021-pol2qm74	3790	5	)	)	-RRB-
cord-015021-pol2qm74	3790	6	received	receive	VBD
cord-015021-pol2qm74	3790	7	same	same	JJ
cord-015021-pol2qm74	3790	8	volume	volume	NN
cord-015021-pol2qm74	3790	9	of	of	IN
cord-015021-pol2qm74	3790	10	saline	saline	NN
cord-015021-pol2qm74	3790	11	at	at	IN
cord-015021-pol2qm74	3790	12	the	the	DT
cord-015021-pol2qm74	3790	13	same	same	JJ
cord-015021-pol2qm74	3790	14	times	time	NNS
cord-015021-pol2qm74	3790	15	before	before	IN
cord-015021-pol2qm74	3790	16	the	the	DT
cord-015021-pol2qm74	3790	17	LPS	LPS	NNP
cord-015021-pol2qm74	3790	18	insult	insult	NN
cord-015021-pol2qm74	3790	19	.	.	.
cord-015021-pol2qm74	3791	1	At	at	IN
cord-015021-pol2qm74	3791	2	the	the	DT
cord-015021-pol2qm74	3791	3	appropriate	appropriate	JJ
cord-015021-pol2qm74	3791	4	time	time	NN
cord-015021-pol2qm74	3791	5	points	point	NNS
cord-015021-pol2qm74	3791	6	after	after	IN
cord-015021-pol2qm74	3791	7	LPS	LPS	NNP
cord-015021-pol2qm74	3791	8	injection	injection	NN
cord-015021-pol2qm74	3791	9	animals	animal	NNS
cord-015021-pol2qm74	3791	10	were	be	VBD
cord-015021-pol2qm74	3791	11	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	3791	12	and	and	CC
cord-015021-pol2qm74	3791	13	venous	venous	JJ
cord-015021-pol2qm74	3791	14	blood	blood	NN
cord-015021-pol2qm74	3791	15	was	be	VBD
cord-015021-pol2qm74	3791	16	collected	collect	VBN
cord-015021-pol2qm74	3791	17	from	from	IN
cord-015021-pol2qm74	3791	18	the	the	DT
cord-015021-pol2qm74	3791	19	inferior	inferior	JJ
cord-015021-pol2qm74	3791	20	vena	vena	FW
cord-015021-pol2qm74	3791	21	cava	cava	NN
cord-015021-pol2qm74	3791	22	.	.	.
cord-015021-pol2qm74	3792	1	The	the	DT
cord-015021-pol2qm74	3792	2	plasma	plasma	NN
cord-015021-pol2qm74	3792	3	levels	level	NNS
cord-015021-pol2qm74	3792	4	of	of	IN
cord-015021-pol2qm74	3792	5	TNF	TNF	NNP
cord-015021-pol2qm74	3792	6	-	-	HYPH
cord-015021-pol2qm74	3792	7	cc	cc	NNP
cord-015021-pol2qm74	3792	8	and	and	CC
cord-015021-pol2qm74	3792	9	IL	IL	NNP
cord-015021-pol2qm74	3792	10	-	-	HYPH
cord-015021-pol2qm74	3792	11	loc	loc	NNP
cord-015021-pol2qm74	3792	12	were	be	VBD
cord-015021-pol2qm74	3792	13	determined	determine	VBN
cord-015021-pol2qm74	3792	14	by	by	IN
cord-015021-pol2qm74	3792	15	ELISA	ELISA	NNP
cord-015021-pol2qm74	3792	16	.	.	.
cord-015021-pol2qm74	3793	1	In	in	IN
cord-015021-pol2qm74	3793	2	the	the	DT
cord-015021-pol2qm74	3793	3	mortality	mortality	NN
cord-015021-pol2qm74	3793	4	study	study	NN
cord-015021-pol2qm74	3793	5	,	,	,
cord-015021-pol2qm74	3793	6	each	each	DT
cord-015021-pol2qm74	3793	7	grou	grou	NN
cord-015021-pol2qm74	3793	8	 	 	_SP
cord-015021-pol2qm74	3793	9	The	the	DT
cord-015021-pol2qm74	3793	10	data	datum	NNS
cord-015021-pol2qm74	3793	11	showed	show	VBD
cord-015021-pol2qm74	3793	12	that	that	IN
cord-015021-pol2qm74	3793	13	isoproterenol	isoproterenol	NN
cord-015021-pol2qm74	3793	14	significantly	significantly	RB
cord-015021-pol2qm74	3793	15	decreased	decrease	VBD
cord-015021-pol2qm74	3793	16	the	the	DT
cord-015021-pol2qm74	3793	17	mortality	mortality	NN
cord-015021-pol2qm74	3793	18	and	and	CC
cord-015021-pol2qm74	3793	19	the	the	DT
cord-015021-pol2qm74	3793	20	circulatory	circulatory	JJ
cord-015021-pol2qm74	3793	21	levels	level	NNS
cord-015021-pol2qm74	3793	22	of	of	IN
cord-015021-pol2qm74	3793	23	TNF	TNF	NNP
cord-015021-pol2qm74	3793	24	-	-	HYPH
cord-015021-pol2qm74	3793	25	c~	c~	NNP
cord-015021-pol2qm74	3793	26	and	and	CC
cord-015021-pol2qm74	3793	27	IL	IL	NNP
cord-015021-pol2qm74	3793	28	-	-	HYPH
cord-015021-pol2qm74	3793	29	lcc	lcc	NNP
cord-015021-pol2qm74	3793	30	(	(	-LRB-
cord-015021-pol2qm74	3793	31	Fig	Fig	NNP
cord-015021-pol2qm74	3793	32	.	.	.
cord-015021-pol2qm74	3793	33	1	1	CD
cord-015021-pol2qm74	3793	34	)	)	-RRB-
cord-015021-pol2qm74	3793	35	.	.	.
cord-015021-pol2qm74	3794	1	These	these	DT
cord-015021-pol2qm74	3794	2	data	datum	NNS
cord-015021-pol2qm74	3794	3	suggest	suggest	VBP
cord-015021-pol2qm74	3794	4	that	that	IN
cord-015021-pol2qm74	3794	5	13-AR	13-ar	CD
cord-015021-pol2qm74	3794	6	activation	activation	NN
cord-015021-pol2qm74	3794	7	of	of	IN
cord-015021-pol2qm74	3794	8	immunocytes	immunocyte	NNS
cord-015021-pol2qm74	3794	9	down	down	RB
cord-015021-pol2qm74	3794	10	regulates	regulate	VBZ
cord-015021-pol2qm74	3794	11	cytokine	cytokine	JJ
cord-015021-pol2qm74	3794	12	gene	gene	NN
cord-015021-pol2qm74	3794	13	expression	expression	NN
cord-015021-pol2qm74	3794	14	,	,	,
cord-015021-pol2qm74	3794	15	decreasing	decrease	VBG
cord-015021-pol2qm74	3794	16	circulatory	circulatory	JJ
cord-015021-pol2qm74	3794	17	eytokine	eytokine	JJ
cord-015021-pol2qm74	3794	18	levels	level	NNS
cord-015021-pol2qm74	3794	19	thus	thus	RB
cord-015021-pol2qm74	3794	20	reducing	reduce	VBG
cord-015021-pol2qm74	3794	21	endotoxicosis	endotoxicosis	NNP
cord-015021-pol2qm74	3794	22	mortality	mortality	NN
cord-015021-pol2qm74	3794	23	.	.	.
cord-015021-pol2qm74	3795	1	These	these	DT
cord-015021-pol2qm74	3795	2	results	result	NNS
cord-015021-pol2qm74	3795	3	provide	provide	VBP
cord-015021-pol2qm74	3795	4	a	a	DT
cord-015021-pol2qm74	3795	5	new	new	JJ
cord-015021-pol2qm74	3795	6	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	3795	7	approach	approach	NN
cord-015021-pol2qm74	3795	8	to	to	TO
cord-015021-pol2qm74	3795	9	reduce	reduce	VB
cord-015021-pol2qm74	3795	10	the	the	DT
cord-015021-pol2qm74	3795	11	excess	excess	NN
cord-015021-pol2qm74	3795	12	of	of	IN
cord-015021-pol2qm74	3795	13	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	3795	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	3795	15	and	and	CC
cord-015021-pol2qm74	3795	16	mortality	mortality	NN
cord-015021-pol2qm74	3795	17	in	in	IN
cord-015021-pol2qm74	3795	18	sepsis	sepsis	NN
cord-015021-pol2qm74	3795	19	.	.	.
cord-015021-pol2qm74	3796	1	Introduction	introduction	NN
cord-015021-pol2qm74	3796	2	:	:	:
cord-015021-pol2qm74	3797	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	3797	2	released	release	VBN
cord-015021-pol2qm74	3797	3	from	from	IN
cord-015021-pol2qm74	3797	4	monocytic	monocytic	JJ
cord-015021-pol2qm74	3797	5	cells	cell	NNS
cord-015021-pol2qm74	3797	6	are	be	VBP
cord-015021-pol2qm74	3797	7	thought	think	VBN
cord-015021-pol2qm74	3797	8	to	to	TO
cord-015021-pol2qm74	3797	9	play	play	VB
cord-015021-pol2qm74	3797	10	an	an	DT
cord-015021-pol2qm74	3797	11	important	important	JJ
cord-015021-pol2qm74	3797	12	role	role	NN
cord-015021-pol2qm74	3797	13	in	in	IN
cord-015021-pol2qm74	3797	14	the	the	DT
cord-015021-pol2qm74	3797	15	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	3797	16	of	of	IN
cord-015021-pol2qm74	3797	17	sepsis	sepsis	NN
cord-015021-pol2qm74	3797	18	.	.	.
cord-015021-pol2qm74	3798	1	During	during	IN
cord-015021-pol2qm74	3798	2	the	the	DT
cord-015021-pol2qm74	3798	3	last	last	JJ
cord-015021-pol2qm74	3798	4	few	few	JJ
cord-015021-pol2qm74	3798	5	years	year	NNS
cord-015021-pol2qm74	3798	6	several	several	JJ
cord-015021-pol2qm74	3798	7	investigations	investigation	NNS
cord-015021-pol2qm74	3798	8	have	have	VBP
cord-015021-pol2qm74	3798	9	been	be	VBN
cord-015021-pol2qm74	3798	10	performed	perform	VBN
cord-015021-pol2qm74	3798	11	aimed	aim	VBN
cord-015021-pol2qm74	3798	12	at	at	IN
cord-015021-pol2qm74	3798	13	modulating	modulate	VBG
cord-015021-pol2qm74	3798	14	this	this	DT
cord-015021-pol2qm74	3798	15	mediator	mediator	NN
cord-015021-pol2qm74	3798	16	response	response	NN
cord-015021-pol2qm74	3798	17	.	.	.
cord-015021-pol2qm74	3799	1	In	in	IN
cord-015021-pol2qm74	3799	2	the	the	DT
cord-015021-pol2qm74	3799	3	present	present	JJ
cord-015021-pol2qm74	3799	4	investigation	investigation	NN
cord-015021-pol2qm74	3799	5	using	use	VBG
cord-015021-pol2qm74	3799	6	a	a	DT
cord-015021-pol2qm74	3799	7	full	full	JJ
cord-015021-pol2qm74	3799	8	blood	blood	NN
cord-015021-pol2qm74	3799	9	model	model	NN
cord-015021-pol2qm74	3799	10	we	-PRON-	PRP
cord-015021-pol2qm74	3799	11	have	have	VBP
cord-015021-pol2qm74	3799	12	studied	study	VBN
cord-015021-pol2qm74	3799	13	the	the	DT
cord-015021-pol2qm74	3799	14	effect	effect	NN
cord-015021-pol2qm74	3799	15	of	of	IN
cord-015021-pol2qm74	3799	16	a	a	DT
cord-015021-pol2qm74	3799	17	standard	standard	JJ
cord-015021-pol2qm74	3799	18	immune	immune	JJ
cord-015021-pol2qm74	3799	19	globulin	globulin	NN
cord-015021-pol2qm74	3799	20	and	and	CC
cord-015021-pol2qm74	3799	21	an	an	DT
cord-015021-pol2qm74	3799	22	antitipopolysaccharide	antitipopolysaccharide	NN
cord-015021-pol2qm74	3799	23	(	(	-LRB-
cord-015021-pol2qm74	3799	24	LPS	LPS	NNP
cord-015021-pol2qm74	3799	25	)	)	-RRB-
cord-015021-pol2qm74	3799	26	immune	immune	JJ
cord-015021-pol2qm74	3799	27	globulin	globulin	NN
cord-015021-pol2qm74	3799	28	preparation	preparation	NN
cord-015021-pol2qm74	3799	29	and	and	CC
cord-015021-pol2qm74	3799	30	a	a	DT
cord-015021-pol2qm74	3799	31	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	3799	32	anti	anti	JJ
cord-015021-pol2qm74	3799	33	-	-	JJ
cord-015021-pol2qm74	3799	34	LPS	lps	JJ
cord-015021-pol2qm74	3799	35	antibody	antibody	NN
cord-015021-pol2qm74	3799	36	in	in	IN
cord-015021-pol2qm74	3799	37	modulating	modulate	VBG
cord-015021-pol2qm74	3799	38	the	the	DT
cord-015021-pol2qm74	3799	39	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3799	40	induced	induce	VBN
cord-015021-pol2qm74	3799	41	cytokine	cytokine	NN
cord-015021-pol2qm74	3799	42	response	response	NN
cord-015021-pol2qm74	3799	43	.	.	.
cord-015021-pol2qm74	3800	1	Methods	method	NNS
cord-015021-pol2qm74	3800	2	:	:	:
cord-015021-pol2qm74	3800	3	Citrated	citrate	VBN
cord-015021-pol2qm74	3800	4	blood	blood	NN
cord-015021-pol2qm74	3800	5	from	from	IN
cord-015021-pol2qm74	3800	6	healthy	healthy	JJ
cord-015021-pol2qm74	3800	7	human	human	JJ
cord-015021-pol2qm74	3800	8	donors	donor	NNS
cord-015021-pol2qm74	3800	9	was	be	VBD
cord-015021-pol2qm74	3800	10	incubated	incubate	VBN
cord-015021-pol2qm74	3800	11	at	at	IN
cord-015021-pol2qm74	3800	12	37	37	CD
cord-015021-pol2qm74	3800	13	°	°	NN
cord-015021-pol2qm74	3800	14	C	c	NN
cord-015021-pol2qm74	3800	15	in	in	IN
cord-015021-pol2qm74	3800	16	rotating	rotate	VBG
cord-015021-pol2qm74	3800	17	polystyrene	polystyrene	NN
cord-015021-pol2qm74	3800	18	tubes	tube	NNS
cord-015021-pol2qm74	3800	19	.	.	.
cord-015021-pol2qm74	3801	1	Samples	sample	NNS
cord-015021-pol2qm74	3801	2	were	be	VBD
cord-015021-pol2qm74	3801	3	taken	take	VBN
cord-015021-pol2qm74	3801	4	before	before	IN
cord-015021-pol2qm74	3801	5	addition	addition	NN
cord-015021-pol2qm74	3801	6	of	of	IN
cord-015021-pol2qm74	3801	7	1	1	CD
cord-015021-pol2qm74	3801	8	x	x	SYM
cord-015021-pol2qm74	3801	9	103	103	CD
cord-015021-pol2qm74	3801	10	ng	ng	NNP
cord-015021-pol2qm74	3801	11	/	/	SYM
cord-015021-pol2qm74	3801	12	l	l	NNP
cord-015021-pol2qm74	3801	13	E.	E.	NNP
cord-015021-pol2qm74	3801	14	col±	col±	NNP
cord-015021-pol2qm74	3801	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3801	16	and	and	CC
cord-015021-pol2qm74	3801	17	after	after	IN
cord-015021-pol2qm74	3801	18	2	2	CD
cord-015021-pol2qm74	3801	19	hours	hour	NNS
cord-015021-pol2qm74	3801	20	.	.	.
cord-015021-pol2qm74	3802	1	Plasma	plasma	NN
cord-015021-pol2qm74	3802	2	was	be	VBD
cord-015021-pol2qm74	3802	3	assayed	assay	VBN
cord-015021-pol2qm74	3802	4	for	for	IN
cord-015021-pol2qm74	3802	5	the	the	DT
cord-015021-pol2qm74	3802	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	3802	7	minor	minor	JJ
cord-015021-pol2qm74	3802	8	necrosis	necrosis	NN
cord-015021-pol2qm74	3802	9	factor	factor	NN
cord-015021-pol2qm74	3802	10	alpha	alpha	NN
cord-015021-pol2qm74	3802	11	(	(	-LRB-
cord-015021-pol2qm74	3802	12	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	3802	13	)	)	-RRB-
cord-015021-pol2qm74	3802	14	and	and	CC
cord-015021-pol2qm74	3802	15	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	3802	16	(	(	-LRB-
cord-015021-pol2qm74	3802	17	IL-6	IL-6	NNP
cord-015021-pol2qm74	3802	18	)	)	-RRB-
cord-015021-pol2qm74	3802	19	using	use	VBG
cord-015021-pol2qm74	3802	20	ELISA	ELISA	NNP
cord-015021-pol2qm74	3802	21	methods	method	NNS
cord-015021-pol2qm74	3802	22	.	.	.
cord-015021-pol2qm74	3803	1	The	the	DT
cord-015021-pol2qm74	3803	2	eodotoxin	eodotoxin	JJ
cord-015021-pol2qm74	3803	3	concentration	concentration	NN
cord-015021-pol2qm74	3803	4	was	be	VBD
cord-015021-pol2qm74	3803	5	assayed	assay	VBN
cord-015021-pol2qm74	3803	6	by	by	IN
cord-015021-pol2qm74	3803	7	LAL	LAL	NNP
cord-015021-pol2qm74	3803	8	and	and	CC
cord-015021-pol2qm74	3803	9	end	end	NN
cord-015021-pol2qm74	3803	10	-	-	HYPH
cord-015021-pol2qm74	3803	11	point	point	NN
cord-015021-pol2qm74	3803	12	chromogenic	chromogenic	JJ
cord-015021-pol2qm74	3803	13	substrate	substrate	NN
cord-015021-pol2qm74	3803	14	technique	technique	NN
cord-015021-pol2qm74	3803	15	.	.	.
cord-015021-pol2qm74	3804	1	The	the	DT
cord-015021-pol2qm74	3804	2	blood	blood	NN
cord-015021-pol2qm74	3804	3	was	be	VBD
cord-015021-pol2qm74	3804	4	preincubated	preincubate	VBN
cord-015021-pol2qm74	3804	5	with	with	IN
cord-015021-pol2qm74	3804	6	standard	standard	JJ
cord-015021-pol2qm74	3804	7	immune	immune	JJ
cord-015021-pol2qm74	3804	8	globuline	globuline	NN
cord-015021-pol2qm74	3804	9	(	(	-LRB-
cord-015021-pol2qm74	3804	10	human	human	JJ
cord-015021-pol2qm74	3804	11	IgG	igg	NN
cord-015021-pol2qm74	3804	12	from	from	IN
cord-015021-pol2qm74	3804	13	pooled	pool	VBN
cord-015021-pol2qm74	3804	14	plasma	plasma	NN
cord-015021-pol2qm74	3804	15	,	,	,
cord-015021-pol2qm74	3804	16	GammagardR	GammagardR	NNP
cord-015021-pol2qm74	3804	17	,	,	,
cord-015021-pol2qm74	3804	18	Baxter	Baxter	NNP
cord-015021-pol2qm74	3804	19	)	)	-RRB-
cord-015021-pol2qm74	3804	20	or	or	CC
cord-015021-pol2qm74	3804	21	with	with	IN
cord-015021-pol2qm74	3804	22	an	an	DT
cord-015021-pol2qm74	3804	23	anti	anti	JJ
cord-015021-pol2qm74	3804	24	-	-	JJ
cord-015021-pol2qm74	3804	25	LPS	lps	JJ
cord-015021-pol2qm74	3804	26	immune	immune	JJ
cord-015021-pol2qm74	3804	27	glubuline	glubuline	NN
cord-015021-pol2qm74	3804	28	(	(	-LRB-
cord-015021-pol2qm74	3804	29	human	human	JJ
cord-015021-pol2qm74	3804	30	anti	anti	JJ
cord-015021-pol2qm74	3804	31	-	-	JJ
cord-015021-pol2qm74	3804	32	LPS	lps	JJ
cord-015021-pol2qm74	3804	33	IgG	igg	NN
cord-015021-pol2qm74	3804	34	obtained	obtain	VBN
cord-015021-pol2qm74	3804	35	by	by	IN
cord-015021-pol2qm74	3804	36	screening	screening	NN
cord-015021-pol2qm74	3804	37	of	of	IN
cord-015021-pol2qm74	3804	38	blood	blood	NN
cord-015021-pol2qm74	3804	39	donors	donor	NNS
cord-015021-pol2qm74	3804	40	,	,	,
cord-015021-pol2qm74	3804	41	Novo	Novo	NNP
cord-015021-pol2qm74	3804	42	Nordisk	Nordisk	NNP
cord-015021-pol2qm74	3804	43	)	)	-RRB-
cord-015021-pol2qm74	3804	44	in	in	IN
cord-015021-pol2qm74	3804	45	the	the	DT
cord-015021-pol2qm74	3804	46	concentrations	concentration	NNS
cord-015021-pol2qm74	3804	47	of	of	IN
cord-015021-pol2qm74	3804	48	4mg	4mg	NN
cord-015021-pol2qm74	3804	49	/	/	SYM
cord-015021-pol2qm74	3804	50	ml	ml	NN
cord-015021-pol2qm74	3804	51	or	or	CC
cord-015021-pol2qm74	3804	52	8	8	CD
cord-015021-pol2qm74	3804	53	mg	mg	NNP
cord-015021-pol2qm74	3804	54	/	/	SYM
cord-015021-pol2qm74	3804	55	ml	ml	NN
cord-015021-pol2qm74	3804	56	or	or	CC
cord-015021-pol2qm74	3804	57	with	with	IN
cord-015021-pol2qm74	3804	58	the	the	DT
cord-015021-pol2qm74	3804	59	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	3804	60	lipid	lipid	NN
cord-015021-pol2qm74	3804	61	A	a	DT
cord-015021-pol2qm74	3804	62	IgM	igm	NN
cord-015021-pol2qm74	3804	63	antibody	antibody	NN
cord-015021-pol2qm74	3804	64	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	3804	65	for	for	IN
cord-015021-pol2qm74	3804	66	ten	ten	CD
cord-015021-pol2qm74	3804	67	minutes	minute	NNS
cord-015021-pol2qm74	3804	68	before	before	IN
cord-015021-pol2qm74	3804	69	the	the	DT
cord-015021-pol2qm74	3804	70	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3804	71	was	be	VBD
cord-015021-pol2qm74	3804	72	added	add	VBN
cord-015021-pol2qm74	3804	73	.	.	.
cord-015021-pol2qm74	3805	1	Results	result	NNS
cord-015021-pol2qm74	3805	2	:	:	:
cord-015021-pol2qm74	3806	1	Two	two	CD
cord-015021-pol2qm74	3806	2	hours	hour	NNS
cord-015021-pol2qm74	3806	3	after	after	IN
cord-015021-pol2qm74	3806	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3806	5	addition	addition	NN
cord-015021-pol2qm74	3806	6	markedly	markedly	RB
cord-015021-pol2qm74	3806	7	elevated	elevate	VBD
cord-015021-pol2qm74	3806	8	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	3806	9	and	and	CC
cord-015021-pol2qm74	3806	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	3806	11	values	value	NNS
cord-015021-pol2qm74	3806	12	were	be	VBD
cord-015021-pol2qm74	3806	13	found.in	found.in	,
cord-015021-pol2qm74	3806	14	the	the	DT
cord-015021-pol2qm74	3806	15	plasma	plasma	NN
cord-015021-pol2qm74	3806	16	.	.	.
cord-015021-pol2qm74	3807	1	Cytokine	cytokine	NN
cord-015021-pol2qm74	3807	2	values	value	NNS
cord-015021-pol2qm74	3807	3	at	at	IN
cord-015021-pol2qm74	3807	4	2	2	CD
cord-015021-pol2qm74	3807	5	hours	hour	NNS
cord-015021-pol2qm74	3807	6	:	:	:
cord-015021-pol2qm74	3807	7	TNF	TNF	NNP
cord-015021-pol2qm74	3807	8	-	-	HYPH
cord-015021-pol2qm74	3807	9	ec	ec	NNP
cord-015021-pol2qm74	3807	10	1689	1689	CD
cord-015021-pol2qm74	3807	11	pg	pg	NNP
cord-015021-pol2qm74	3807	12	/	/	SYM
cord-015021-pol2qm74	3807	13	ml	ml	NNP
cord-015021-pol2qm74	3807	14	(	(	-LRB-
cord-015021-pol2qm74	3807	15	mean	mean	VB
cord-015021-pol2qm74	3807	16	)	)	-RRB-
cord-015021-pol2qm74	3807	17	and	and	CC
cord-015021-pol2qm74	3807	18	1L-6	1l-6	CD
cord-015021-pol2qm74	3807	19	1123	1123	CD
cord-015021-pol2qm74	3807	20	pg	pg	NN
cord-015021-pol2qm74	3807	21	/	/	SYM
cord-015021-pol2qm74	3807	22	ml	ml	NN
cord-015021-pol2qm74	3808	1	(	(	-LRB-
cord-015021-pol2qm74	3808	2	mean	mean	VB
cord-015021-pol2qm74	3808	3	)	)	-RRB-
cord-015021-pol2qm74	3808	4	.	.	.
cord-015021-pol2qm74	3809	1	Preincubalion	Preincubalion	NNP
cord-015021-pol2qm74	3809	2	with	with	IN
cord-015021-pol2qm74	3809	3	8	8	CD
cord-015021-pol2qm74	3809	4	mg	mg	NNP
cord-015021-pol2qm74	3809	5	/	/	SYM
cord-015021-pol2qm74	3809	6	ml	ml	IN
cord-015021-pol2qm74	3809	7	standard	standard	JJ
cord-015021-pol2qm74	3809	8	immune	immune	JJ
cord-015021-pol2qm74	3809	9	globulins	globulin	NNS
cord-015021-pol2qm74	3809	10	reduced	reduce	VBD
cord-015021-pol2qm74	3809	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	3809	12	values	value	NNS
cord-015021-pol2qm74	3809	13	by	by	IN
cord-015021-pol2qm74	3809	14	49	49	CD
cord-015021-pol2qm74	3809	15	%	%	NN
cord-015021-pol2qm74	3809	16	(	(	-LRB-
cord-015021-pol2qm74	3809	17	mean	mean	VB
cord-015021-pol2qm74	3809	18	)	)	-RRB-
cord-015021-pol2qm74	3809	19	while	while	IN
cord-015021-pol2qm74	3809	20	there	there	EX
cord-015021-pol2qm74	3809	21	were	be	VBD
cord-015021-pol2qm74	3809	22	no	no	DT
cord-015021-pol2qm74	3809	23	effects	effect	NNS
cord-015021-pol2qm74	3809	24	on	on	IN
cord-015021-pol2qm74	3809	25	TNF	TNF	NNP
cord-015021-pol2qm74	3809	26	-	-	HYPH
cord-015021-pol2qm74	3809	27	c~	c~	NNP
cord-015021-pol2qm74	3809	28	values	value	NNS
cord-015021-pol2qm74	3809	29	at	at	IN
cord-015021-pol2qm74	3809	30	2	2	CD
cord-015021-pol2qm74	3809	31	hours	hour	NNS
cord-015021-pol2qm74	3809	32	.	.	.
cord-015021-pol2qm74	3810	1	A	a	DT
cord-015021-pol2qm74	3810	2	slight	slight	JJ
cord-015021-pol2qm74	3810	3	reduction	reduction	NN
cord-015021-pol2qm74	3810	4	in	in	IN
cord-015021-pol2qm74	3810	5	IL-6	IL-6	NNP
cord-015021-pol2qm74	3810	6	values	value	NNS
cord-015021-pol2qm74	3810	7	was	be	VBD
cord-015021-pol2qm74	3810	8	also	also	RB
cord-015021-pol2qm74	3810	9	found	find	VBN
cord-015021-pol2qm74	3810	10	with	with	IN
cord-015021-pol2qm74	3810	11	the	the	DT
cord-015021-pol2qm74	3810	12	lower	low	JJR
cord-015021-pol2qm74	3810	13	concentration	concentration	NN
cord-015021-pol2qm74	3810	14	,	,	,
cord-015021-pol2qm74	3810	15	4mg	4mg	NN
cord-015021-pol2qm74	3810	16	/	/	SYM
cord-015021-pol2qm74	3810	17	ml	ml	XX
cord-015021-pol2qm74	3810	18	,	,	,
cord-015021-pol2qm74	3810	19	but	but	CC
cord-015021-pol2qm74	3810	20	this	this	DT
cord-015021-pol2qm74	3810	21	was	be	VBD
cord-015021-pol2qm74	3810	22	not	not	RB
cord-015021-pol2qm74	3810	23	statistically	statistically	RB
cord-015021-pol2qm74	3810	24	significant	significant	JJ
cord-015021-pol2qm74	3810	25	.	.	.
cord-015021-pol2qm74	3811	1	Preincubation	preincubation	NN
cord-015021-pol2qm74	3811	2	with	with	IN
cord-015021-pol2qm74	3811	3	anti	anti	JJ
cord-015021-pol2qm74	3811	4	-	-	JJ
cord-015021-pol2qm74	3811	5	LPS	lps	JJ
cord-015021-pol2qm74	3811	6	immune	immune	JJ
cord-015021-pol2qm74	3811	7	globulins	globulin	NNS
cord-015021-pol2qm74	3811	8	had	have	VBD
cord-015021-pol2qm74	3811	9	no	no	DT
cord-015021-pol2qm74	3811	10	effect	effect	NN
cord-015021-pol2qm74	3811	11	on	on	IN
cord-015021-pol2qm74	3811	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	3811	13	nor	nor	CC
cord-015021-pol2qm74	3811	14	on	on	IN
cord-015021-pol2qm74	3811	15	TNF	TNF	NNP
cord-015021-pol2qm74	3811	16	-	-	HYPH
cord-015021-pol2qm74	3811	17	cc	cc	NNP
cord-015021-pol2qm74	3811	18	values	value	NNS
cord-015021-pol2qm74	3811	19	.	.	.
cord-015021-pol2qm74	3812	1	Preincubation	preincubation	NN
cord-015021-pol2qm74	3812	2	with	with	IN
cord-015021-pol2qm74	3812	3	the	the	DT
cord-015021-pol2qm74	3812	4	monoclottal	monoclottal	JJ
cord-015021-pol2qm74	3812	5	lipid	lipid	NN
cord-015021-pol2qm74	3812	6	A	a	DT
cord-015021-pol2qm74	3812	7	IgM	igm	NN
cord-015021-pol2qm74	3812	8	antibody	antibody	NN
cord-015021-pol2qm74	3812	9	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	3812	10	in	in	IN
cord-015021-pol2qm74	3812	11	variable	variable	JJ
cord-015021-pol2qm74	3812	12	concentrations	concentration	NNS
cord-015021-pol2qm74	3812	13	had	have	VBD
cord-015021-pol2qm74	3812	14	no	no	DT
cord-015021-pol2qm74	3812	15	effect	effect	NN
cord-015021-pol2qm74	3812	16	on	on	IN
cord-015021-pol2qm74	3812	17	cytokine	cytokine	NN
cord-015021-pol2qm74	3812	18	release	release	NN
cord-015021-pol2qm74	3812	19	in	in	IN
cord-015021-pol2qm74	3812	20	this	this	DT
cord-015021-pol2qm74	3812	21	model	model	NN
cord-015021-pol2qm74	3812	22	.	.	.
cord-015021-pol2qm74	3813	1	In	in	IN
cord-015021-pol2qm74	3813	2	this	this	DT
cord-015021-pol2qm74	3813	3	full	full	JJ
cord-015021-pol2qm74	3813	4	blood	blood	NN
cord-015021-pol2qm74	3813	5	in	in	IN
cord-015021-pol2qm74	3813	6	vitro	vitro	FW
cord-015021-pol2qm74	3813	7	model	model	JJ
cord-015021-pol2qm74	3813	8	standard	standard	JJ
cord-015021-pol2qm74	3813	9	immune	immune	JJ
cord-015021-pol2qm74	3813	10	globuline	globuline	JJ
cord-015021-pol2qm74	3813	11	reduced	reduce	VBN
cord-015021-pol2qm74	3813	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3813	13	induced	induce	VBN
cord-015021-pol2qm74	3813	14	1L-6	1l-6	CD
cord-015021-pol2qm74	3813	15	release	release	NN
cord-015021-pol2qm74	3813	16	while	while	IN
cord-015021-pol2qm74	3813	17	TNF	TNF	NNP
cord-015021-pol2qm74	3813	18	-	-	HYPH
cord-015021-pol2qm74	3813	19	cc	cc	CD
cord-015021-pol2qm74	3813	20	values	value	NNS
cord-015021-pol2qm74	3813	21	were	be	VBD
cord-015021-pol2qm74	3813	22	unchanged	unchanged	JJ
cord-015021-pol2qm74	3813	23	.	.	.
cord-015021-pol2qm74	3814	1	The	the	DT
cord-015021-pol2qm74	3814	2	anti	anti	JJ
cord-015021-pol2qm74	3814	3	-	-	JJ
cord-015021-pol2qm74	3814	4	LPS	lps	JJ
cord-015021-pol2qm74	3814	5	immune	immune	JJ
cord-015021-pol2qm74	3814	6	glubuline	glubuline	JJ
cord-015021-pol2qm74	3814	7	preparation	preparation	NN
cord-015021-pol2qm74	3814	8	and	and	CC
cord-015021-pol2qm74	3814	9	the	the	DT
cord-015021-pol2qm74	3814	10	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	3814	11	lipid	lipid	NN
cord-015021-pol2qm74	3815	1	A	a	DT
cord-015021-pol2qm74	3815	2	IgM	igm	NN
cord-015021-pol2qm74	3815	3	antibody	antibody	NN
cord-015021-pol2qm74	3815	4	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	3815	5	had	have	VBD
cord-015021-pol2qm74	3815	6	no	no	DT
cord-015021-pol2qm74	3815	7	effect	effect	NN
cord-015021-pol2qm74	3815	8	on	on	IN
cord-015021-pol2qm74	3815	9	the	the	DT
cord-015021-pol2qm74	3815	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	3815	11	or	or	CC
cord-015021-pol2qm74	3815	12	TNF	TNF	NNP
cord-015021-pol2qm74	3815	13	-	-	HYPH
cord-015021-pol2qm74	3815	14	ct	ct	NNP
cord-015021-pol2qm74	3815	15	release	release	NN
cord-015021-pol2qm74	3815	16	.	.	.
cord-015021-pol2qm74	3816	1	The	the	DT
cord-015021-pol2qm74	3816	2	effect	effect	NN
cord-015021-pol2qm74	3816	3	of	of	IN
cord-015021-pol2qm74	3816	4	anti	anti	JJ
cord-015021-pol2qm74	3816	5	-	-	JJ
cord-015021-pol2qm74	3816	6	TNF	TNF	NNP
cord-015021-pol2qm74	3816	7	treatment	treatment	NN
cord-015021-pol2qm74	3816	8	in	in	IN
cord-015021-pol2qm74	3816	9	severe	severe	JJ
cord-015021-pol2qm74	3816	10	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	3816	11	/	/	SYM
cord-015021-pol2qm74	3816	12	traumatic	traumatic	JJ
cord-015021-pol2qm74	3816	13	shock	shock	NN
cord-015021-pol2qm74	3816	14	was	be	VBD
cord-015021-pol2qm74	3816	15	investigated	investigate	VBN
cord-015021-pol2qm74	3816	16	in	in	IN
cord-015021-pol2qm74	3816	17	a	a	DT
cord-015021-pol2qm74	3816	18	conscious	conscious	JJ
cord-015021-pol2qm74	3816	19	rabbit	rabbit	NN
cord-015021-pol2qm74	3816	20	model	model	NN
cord-015021-pol2qm74	3816	21	.	.	.
cord-015021-pol2qm74	3817	1	The	the	DT
cord-015021-pol2qm74	3817	2	jugular	jugular	NN
cord-015021-pol2qm74	3817	3	vein	vein	NN
cord-015021-pol2qm74	3817	4	(	(	-LRB-
cord-015021-pol2qm74	3817	5	for	for	IN
cord-015021-pol2qm74	3817	6	administration	administration	NN
cord-015021-pol2qm74	3817	7	of	of	IN
cord-015021-pol2qm74	3817	8	substances	substance	NNS
cord-015021-pol2qm74	3817	9	and	and	CC
cord-015021-pol2qm74	3817	10	blood	blood	NN
cord-015021-pol2qm74	3817	11	withdrawal	withdrawal	NN
cord-015021-pol2qm74	3817	12	)	)	-RRB-
cord-015021-pol2qm74	3817	13	and	and	CC
cord-015021-pol2qm74	3817	14	right	right	JJ
cord-015021-pol2qm74	3817	15	femoral	femoral	JJ
cord-015021-pol2qm74	3817	16	artery	artery	NN
cord-015021-pol2qm74	3817	17	(	(	-LRB-
cord-015021-pol2qm74	3817	18	for	for	IN
cord-015021-pol2qm74	3817	19	measurement	measurement	NN
cord-015021-pol2qm74	3817	20	of	of	IN
cord-015021-pol2qm74	3817	21	BP	BP	NNP
cord-015021-pol2qm74	3817	22	)	)	-RRB-
cord-015021-pol2qm74	3817	23	were	be	VBD
cord-015021-pol2qm74	3817	24	cannulated	cannulate	VBN
cord-015021-pol2qm74	3817	25	and	and	CC
cord-015021-pol2qm74	3817	26	an	an	DT
cord-015021-pol2qm74	3817	27	aortic	aortic	JJ
cord-015021-pol2qm74	3817	28	thermistor	thermistor	NN
cord-015021-pol2qm74	3817	29	probe	probe	NN
cord-015021-pol2qm74	3817	30	inserted	insert	VBN
cord-015021-pol2qm74	3817	31	into	into	IN
cord-015021-pol2qm74	3817	32	the	the	DT
cord-015021-pol2qm74	3817	33	left	left	JJ
cord-015021-pol2qm74	3817	34	;	;	:
cord-015021-pol2qm74	3817	35	femoral	femoral	JJ
cord-015021-pol2qm74	3817	36	artery	artery	NN
cord-015021-pol2qm74	3817	37	for	for	IN
cord-015021-pol2qm74	3817	38	the	the	DT
cord-015021-pol2qm74	3817	39	measurement	measurement	NN
cord-015021-pol2qm74	3817	40	of	of	IN
cord-015021-pol2qm74	3817	41	cardiac	cardiac	JJ
cord-015021-pol2qm74	3817	42	output	output	NN
cord-015021-pol2qm74	3817	43	(	(	-LRB-
cord-015021-pol2qm74	3817	44	CO	CO	NNP
cord-015021-pol2qm74	3817	45	)	)	-RRB-
cord-015021-pol2qm74	3817	46	.	.	.
cord-015021-pol2qm74	3818	1	The	the	DT
cord-015021-pol2qm74	3818	2	following	following	JJ
cord-015021-pol2qm74	3818	3	day	day	NN
cord-015021-pol2qm74	3818	4	,	,	,
cord-015021-pol2qm74	3818	5	upto	upto	RB
cord-015021-pol2qm74	3818	6	40	40	CD
cord-015021-pol2qm74	3818	7	%	%	NN
cord-015021-pol2qm74	3818	8	of	of	IN
cord-015021-pol2qm74	3818	9	the	the	DT
cord-015021-pol2qm74	3818	10	estimated	estimate	VBN
cord-015021-pol2qm74	3818	11	blood	blood	NN
cord-015021-pol2qm74	3818	12	volume	volume	NN
cord-015021-pol2qm74	3818	13	was	be	VBD
cord-015021-pol2qm74	3818	14	withdrawn	withdraw	VBN
cord-015021-pol2qm74	3818	15	over	over	IN
cord-015021-pol2qm74	3818	16	80	80	CD
cord-015021-pol2qm74	3818	17	-	-	SYM
cord-015021-pol2qm74	3818	18	40	40	CD
cord-015021-pol2qm74	3818	19	rain	rain	NN
cord-015021-pol2qm74	3818	20	,	,	,
cord-015021-pol2qm74	3818	21	to	to	TO
cord-015021-pol2qm74	3818	22	reduce	reduce	VB
cord-015021-pol2qm74	3818	23	BP	BP	NNP
cord-015021-pol2qm74	3818	24	to	to	IN
cord-015021-pol2qm74	3818	25	40	40	CD
cord-015021-pol2qm74	3818	26	-	-	SYM
cord-015021-pol2qm74	3818	27	50mmttg	50mmttg	CD
cord-015021-pol2qm74	3818	28	and	and	CC
cord-015021-pol2qm74	3818	29	CO	CO	NNP
cord-015021-pol2qm74	3818	30	by	by	IN
cord-015021-pol2qm74	3818	31	2/8	2/8	CD
cord-015021-pol2qm74	3818	32	mad	mad	JJ
cord-015021-pol2qm74	3818	33	withheld	withhold	VBN
cord-015021-pol2qm74	3818	34	for	for	IN
cord-015021-pol2qm74	3818	35	60	60	CD
cord-015021-pol2qm74	3818	36	rain	rain	NN
cord-015021-pol2qm74	3818	37	.	.	.
cord-015021-pol2qm74	3819	1	Shed	shed	VB
cord-015021-pol2qm74	3819	2	blood	blood	NN
cord-015021-pol2qm74	3819	3	(	(	-LRB-
cord-015021-pol2qm74	3819	4	60	60	CD
cord-015021-pol2qm74	3819	5	%	%	NN
cord-015021-pol2qm74	3819	6	)	)	-RRB-
cord-015021-pol2qm74	3819	7	was	be	VBD
cord-015021-pol2qm74	3819	8	then	then	RB
cord-015021-pol2qm74	3819	9	reinfused	reinfuse	VBN
cord-015021-pol2qm74	3819	10	followed	follow	VBN
cord-015021-pol2qm74	3819	11	by	by	IN
cord-015021-pol2qm74	3819	12	lactate	lactate	NN
cord-015021-pol2qm74	3819	13	solution	solution	NN
cord-015021-pol2qm74	3819	14	to	to	TO
cord-015021-pol2qm74	3819	15	give	give	VB
cord-015021-pol2qm74	3819	16	a	a	DT
cord-015021-pol2qm74	3819	17	total	total	JJ
cord-015021-pol2qm74	3819	18	potential	potential	JJ
cord-015021-pol2qm74	3819	19	dreulat%ag	dreulat%ag	NN
cord-015021-pol2qm74	3819	20	fluid	fluid	JJ
cord-015021-pol2qm74	3819	21	volume	volume	NN
cord-015021-pol2qm74	3819	22	of	of	IN
cord-015021-pol2qm74	3819	23	120	120	CD
cord-015021-pol2qm74	3819	24	%	%	NN
cord-015021-pol2qm74	3819	25	.	.	.
cord-015021-pol2qm74	3820	1	Zymoeen	Zymoeen	NNP
cord-015021-pol2qm74	3820	2	activated	activate	VBD
cord-015021-pol2qm74	3820	3	plasma	plasma	NN
cord-015021-pol2qm74	3820	4	(	(	-LRB-
cord-015021-pol2qm74	3820	5	0,36gg	0,36gg	CD
cord-015021-pol2qm74	3820	6	/	/	SYM
cord-015021-pol2qm74	3820	7	ml	ml	NN
cord-015021-pol2qm74	3820	8	)	)	-RRB-
cord-015021-pol2qm74	3820	9	was	be	VBD
cord-015021-pol2qm74	3820	10	given	give	VBN
cord-015021-pol2qm74	3820	11	10	10	CD
cord-015021-pol2qm74	3820	12	rain	rain	NN
cord-015021-pol2qm74	3820	13	prior	prior	RB
cord-015021-pol2qm74	3820	14	to	to	IN
cord-015021-pol2qm74	3820	15	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	3820	16	and	and	CC
cord-015021-pol2qm74	3820	17	during	during	IN
cord-015021-pol2qm74	3820	18	blood	blood	NN
cord-015021-pol2qm74	3820	19	r	r	NN
cord-015021-pol2qm74	3821	1	~n%eion	~n%eion	NNP
cord-015021-pol2qm74	3821	2	,	,	,
cord-015021-pol2qm74	3821	3	All	all	DT
cord-015021-pol2qm74	3821	4	~,~ir	~,~ir	CD
cord-015021-pol2qm74	3821	5	,	,	,
cord-015021-pol2qm74	3821	6	ak	ak	NNP
cord-015021-pol2qm74	3821	7	were	be	VBD
cord-015021-pol2qm74	3821	8	killed	kill	VBN
cord-015021-pol2qm74	3821	9	at	at	IN
cord-015021-pol2qm74	3821	10	72h	72h	NNP
cord-015021-pol2qm74	3821	11	and	and	CC
cord-015021-pol2qm74	3821	12	o	o	NNP
cord-015021-pol2qm74	3821	13	~	~	NFP
cord-015021-pol2qm74	3821	14	gane	gane	NNP
cord-015021-pol2qm74	3821	15	removed	remove	VBD
cord-015021-pol2qm74	3821	16	for	for	IN
cord-015021-pol2qm74	3821	17	histology	histology	NN
cord-015021-pol2qm74	3821	18	.	.	.
cord-015021-pol2qm74	3822	1	Rabbita	Rabbita	NNP
cord-015021-pol2qm74	3822	2	received	receive	VBD
cord-015021-pol2qm74	3822	3	either	either	DT
cord-015021-pol2qm74	3822	4	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	3822	5	antirabbit	antirabbit	NNP
cord-015021-pol2qm74	3822	6	TNF	TNF	NNP
cord-015021-pol2qm74	3822	7	(	(	-LRB-
cord-015021-pol2qm74	3822	8	R6	R6	NNP
cord-015021-pol2qm74	3822	9	,	,	,
cord-015021-pol2qm74	3822	10	rat	rat	NNP
cord-015021-pol2qm74	3822	11	IgG1	IgG1	NNP
cord-015021-pol2qm74	3822	12	,	,	,
cord-015021-pol2qm74	3822	13	8mgkg	8mgkg	CD
cord-015021-pol2qm74	3822	14	i.e.	i.e.	FW
cord-015021-pol2qm74	3822	15	n=7	n=7	NNS
cord-015021-pol2qm74	3822	16	)	)	-RRB-
cord-015021-pol2qm74	3822	17	or	or	CC
cord-015021-pol2qm74	3822	18	eMine	eMine	NNP
cord-015021-pol2qm74	3822	19	(	(	-LRB-
cord-015021-pol2qm74	3822	20	nffi6	nffi6	NN
cord-015021-pol2qm74	3822	21	)	)	-RRB-
cord-015021-pol2qm74	3822	22	,	,	,
cord-015021-pol2qm74	3822	23	60	60	CD
cord-015021-pol2qm74	3822	24	rain	rain	NN
cord-015021-pol2qm74	3822	25	prior	prior	RB
cord-015021-pol2qm74	3822	26	to	to	IN
cord-015021-pol2qm74	3822	27	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	3822	28	.	.	.
cord-015021-pol2qm74	3823	1	The	the	DT
cord-015021-pol2qm74	3823	2	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	3823	3	and	and	CC
cord-015021-pol2qm74	3823	4	biochemical	biochemical	JJ
cord-015021-pol2qm74	3823	5	changes	change	NNS
cord-015021-pol2qm74	3823	6	during	during	IN
cord-015021-pol2qm74	3823	7	the	the	DT
cord-015021-pol2qm74	3823	8	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	3823	9	and	and	CC
cord-015021-pol2qm74	3823	10	hypotensive	hypotensive	JJ
cord-015021-pol2qm74	3823	11	phase	phase	NN
cord-015021-pol2qm74	3823	12	(	(	-LRB-
cord-015021-pol2qm74	3823	13	is	be	VBZ
cord-015021-pol2qm74	3823	14	.	.	.
cord-015021-pol2qm74	3824	1	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	3824	2	stimulus	stimulus	NNP
cord-015021-pol2qm74	3824	3	)	)	-RRB-
cord-015021-pol2qm74	3824	4	were	be	VBD
cord-015021-pol2qm74	3824	5	similar	similar	JJ
cord-015021-pol2qm74	3824	6	in	in	IN
cord-015021-pol2qm74	3824	7	both	both	DT
cord-015021-pol2qm74	3824	8	groups	group	NNS
cord-015021-pol2qm74	3824	9	.	.	.
cord-015021-pol2qm74	3825	1	Upon	upon	IN
cord-015021-pol2qm74	3825	2	reinfusion	reinfusion	NN
cord-015021-pol2qm74	3825	3	,	,	,
cord-015021-pol2qm74	3825	4	haematccrit	haematccrit	NN
cord-015021-pol2qm74	3825	5	and	and	CC
cord-015021-pol2qm74	3825	6	white	white	JJ
cord-015021-pol2qm74	3825	7	cell	cell	NN
cord-015021-pol2qm74	3825	8	count	count	NN
cord-015021-pol2qm74	3825	9	remained	remain	VBD
cord-015021-pol2qm74	3825	10	sigutfia	sigutfia	NNP
cord-015021-pol2qm74	3825	11	~	~	NFP
cord-015021-pol2qm74	3825	12	utly	utly	NN
cord-015021-pol2qm74	3825	13	(	(	-LRB-
cord-015021-pol2qm74	3825	14	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	3825	15	)	)	-RRB-
cord-015021-pol2qm74	3825	16	higher	high	JJR
cord-015021-pol2qm74	3825	17	in	in	IN
cord-015021-pol2qm74	3825	18	saline	saline	NN
cord-015021-pol2qm74	3825	19	compared	compare	VBN
cord-015021-pol2qm74	3825	20	to	to	IN
cord-015021-pol2qm74	3825	21	R6-treated	r6-treate	VBN
cord-015021-pol2qm74	3825	22	animals	animal	NNS
cord-015021-pol2qm74	3825	23	,	,	,
cord-015021-pol2qm74	3825	24	indicating	indicate	VBG
cord-015021-pol2qm74	3825	25	a	a	DT
cord-015021-pol2qm74	3825	26	relative	relative	JJ
cord-015021-pol2qm74	3825	27	haemoconcentration	haemoconcentration	NN
cord-015021-pol2qm74	3825	28	(	(	-LRB-
cord-015021-pol2qm74	3825	29	i	i	PRP
cord-015021-pol2qm74	3825	30	,	,	,
cord-015021-pol2qm74	3825	31	e	e	NNP
cord-015021-pol2qm74	3825	32	.	.	NN
cord-015021-pol2qm74	3825	33	reduced	reduce	VBN
cord-015021-pol2qm74	3825	34	circulating	circulate	VBG
cord-015021-pol2qm74	3825	35	volume	volume	NN
cord-015021-pol2qm74	3825	36	)	)	-RRB-
cord-015021-pol2qm74	3825	37	in	in	IN
cord-015021-pol2qm74	3825	38	saline	saline	NN
cord-015021-pol2qm74	3825	39	animals	animal	NNS
cord-015021-pol2qm74	3825	40	.	.	.
cord-015021-pol2qm74	3826	1	The	the	DT
cord-015021-pol2qm74	3826	2	lettkocytosis	lettkocytosi	NNS
cord-015021-pol2qm74	3826	3	persisted	persist	VBD
cord-015021-pol2qm74	3826	4	in	in	IN
cord-015021-pol2qm74	3826	5	the	the	DT
cord-015021-pol2qm74	3826	6	saline	saline	NN
cord-015021-pol2qm74	3826	7	animals	animal	NNS
cord-015021-pol2qm74	3826	8	upto	upto	IN
cord-015021-pol2qm74	3826	9	72h	72h	NNS
cord-015021-pol2qm74	3826	10	.	.	.
cord-015021-pol2qm74	3827	1	Plasma	plasma	NN
cord-015021-pol2qm74	3827	2	glucose	glucose	NN
cord-015021-pol2qm74	3827	3	,	,	,
cord-015021-pol2qm74	3827	4	lactate	lactate	NN
cord-015021-pol2qm74	3827	5	and	and	CC
cord-015021-pol2qm74	3827	6	asparteto	asparteto	NN
cord-015021-pol2qm74	3827	7	.m~-o	.m~-o	.
cord-015021-pol2qm74	3827	8	transferase	transferase	NNP
cord-015021-pol2qm74	3827	9	all	all	DT
cord-015021-pol2qm74	3827	10	rose	rise	VBD
cord-015021-pol2qm74	3827	11	similarly	similarly	RB
cord-015021-pol2qm74	3827	12	in	in	IN
cord-015021-pol2qm74	3827	13	both	both	DT
cord-015021-pol2qm74	3827	14	gorups	gorup	NNS
cord-015021-pol2qm74	3827	15	but	but	CC
cord-015021-pol2qm74	3827	16	plasma	plasma	NN
cord-015021-pol2qm74	3827	17	¢rea~!~+-e	¢rea~!~+-e	JJ
cord-015021-pol2qm74	3827	18	levels	level	NNS
cord-015021-pol2qm74	3827	19	were	be	VBD
cord-015021-pol2qm74	3827	20	markedly	markedly	RB
cord-015021-pol2qm74	3827	21	(	(	-LRB-
cord-015021-pol2qm74	3827	22	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	3827	23	)	)	-RRB-
cord-015021-pol2qm74	3827	24	higher	high	JJR
cord-015021-pol2qm74	3827	25	in	in	IN
cord-015021-pol2qm74	3827	26	ealine	ealine	NNP
cord-015021-pol2qm74	3827	27	ve	ve	NNP
cord-015021-pol2qm74	3827	28	R6	R6	NNP
cord-015021-pol2qm74	3827	29	animals	animal	NNS
cord-015021-pol2qm74	3827	30	at	at	IN
cord-015021-pol2qm74	3827	31	48	48	CD
cord-015021-pol2qm74	3827	32	and	and	CC
cord-015021-pol2qm74	3827	33	72h	72h	NNS
cord-015021-pol2qm74	3827	34	indicative	indicative	JJ
cord-015021-pol2qm74	3827	35	of	of	IN
cord-015021-pol2qm74	3827	36	kidney	kidney	NN
cord-015021-pol2qm74	3827	37	damage	damage	NN
cord-015021-pol2qm74	3827	38	,	,	,
cord-015021-pol2qm74	3827	39	Using	use	VBG
cord-015021-pol2qm74	3827	40	a	a	DT
cord-015021-pol2qm74	3827	41	macro	macro	NN
cord-015021-pol2qm74	3827	42	and	and	CC
cord-015021-pol2qm74	3827	43	micro	micro	NN
cord-015021-pol2qm74	3827	44	.	.	.
cord-015021-pol2qm74	3828	1	pathological	pathological	JJ
cord-015021-pol2qm74	3828	2	scoring	scoring	NN
cord-015021-pol2qm74	3828	3	system	system	NN
cord-015021-pol2qm74	3828	4	,	,	,
cord-015021-pol2qm74	3828	5	major	major	JJ
cord-015021-pol2qm74	3828	6	organ	organ	NN
cord-015021-pol2qm74	3828	7	damage	damage	NN
cord-015021-pol2qm74	3828	8	was	be	VBD
cord-015021-pol2qm74	3828	9	seen	see	VBN
cord-015021-pol2qm74	3828	10	in	in	IN
cord-015021-pol2qm74	3828	11	the	the	DT
cord-015021-pol2qm74	3828	12	lung	lung	NN
cord-015021-pol2qm74	3828	13	,	,	,
cord-015021-pol2qm74	3828	14	liver	liver	NN
cord-015021-pol2qm74	3828	15	and	and	CC
cord-015021-pol2qm74	3828	16	kidney	kidney	NN
cord-015021-pol2qm74	3828	17	which	which	WDT
cord-015021-pol2qm74	3828	18	was	be	VBD
cord-015021-pol2qm74	3828	19	significantly	significantly	RB
cord-015021-pol2qm74	3828	20	(	(	-LRB-
cord-015021-pol2qm74	3828	21	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	3828	22	)	)	-RRB-
cord-015021-pol2qm74	3828	23	attenuated	attenuate	VBN
cord-015021-pol2qm74	3828	24	in	in	IN
cord-015021-pol2qm74	3828	25	R6	R6	NNP
cord-015021-pol2qm74	3828	26	treated	treat	VBN
cord-015021-pol2qm74	3828	27	animals	animal	NNS
cord-015021-pol2qm74	3828	28	.	.	.
cord-015021-pol2qm74	3829	1	In	in	IN
cord-015021-pol2qm74	3829	2	the	the	DT
cord-015021-pol2qm74	3829	3	hmg	hmg	NNP
cord-015021-pol2qm74	3829	4	and	and	CC
cord-015021-pol2qm74	3829	5	liver	liver	NN
cord-015021-pol2qm74	3829	6	,	,	,
cord-015021-pol2qm74	3829	7	this	this	DT
cord-015021-pol2qm74	3829	8	was	be	VBD
cord-015021-pol2qm74	3829	9	primarily	primarily	RB
cord-015021-pol2qm74	3829	10	due	due	JJ
cord-015021-pol2qm74	3829	11	to	to	IN
cord-015021-pol2qm74	3829	12	a	a	DT
cord-015021-pol2qm74	3829	13	reduced	reduce	VBN
cord-015021-pol2qm74	3829	14	bleeding	bleeding	NN
cord-015021-pol2qm74	3829	15	and	and	CC
cord-015021-pol2qm74	3829	16	PMN	PMN	NNP
cord-015021-pol2qm74	3829	17	infiltrate	infiltrate	VBP
cord-015021-pol2qm74	3829	18	and	and	CC
cord-015021-pol2qm74	3829	19	to	to	IN
cord-015021-pol2qm74	3829	20	an	an	DT
cord-015021-pol2qm74	3829	21	additional	additional	JJ
cord-015021-pol2qm74	3829	22	maintenance	maintenance	NN
cord-015021-pol2qm74	3829	23	of	of	IN
cord-015021-pol2qm74	3829	24	tubular	tubular	JJ
cord-015021-pol2qm74	3829	25	integri~:y	integri~:y	NN
cord-015021-pol2qm74	3829	26	in	in	IN
cord-015021-pol2qm74	3829	27	the	the	DT
cord-015021-pol2qm74	3829	28	kidney	kidney	NN
cord-015021-pol2qm74	3829	29	.	.	.
cord-015021-pol2qm74	3830	1	Hence	hence	RB
cord-015021-pol2qm74	3830	2	,	,	,
cord-015021-pol2qm74	3830	3	in	in	IN
cord-015021-pol2qm74	3830	4	tlais	tlais	NNP
cord-015021-pol2qm74	3830	5	model	model	NN
cord-015021-pol2qm74	3831	1	anti	anti	JJ
cord-015021-pol2qm74	3831	2	-	-	JJ
cord-015021-pol2qm74	3831	3	TNF	TNF	NNP
cord-015021-pol2qm74	3831	4	treatment	treatment	NN
cord-015021-pol2qm74	3831	5	markedly	markedly	RB
cord-015021-pol2qm74	3831	6	reduced	reduce	VBD
cord-015021-pol2qm74	3831	7	the	the	DT
cord-015021-pol2qm74	3831	8	biochemical	biochemical	JJ
cord-015021-pol2qm74	3831	9	and	and	CC
cord-015021-pol2qm74	3831	10	histological	histological	JJ
cord-015021-pol2qm74	3831	11	indices	index	NNS
cord-015021-pol2qm74	3831	12	of	of	IN
cord-015021-pol2qm74	3831	13	severe	severe	JJ
cord-015021-pol2qm74	3831	14	,	,	,
cord-015021-pol2qm74	3831	15	,	,	,
cord-015021-pol2qm74	3831	16	~gan	~gan	NNP
cord-015021-pol2qm74	3831	17	damage	damage	NN
cord-015021-pol2qm74	3831	18	during	during	IN
cord-015021-pol2qm74	3831	19	liaemorrhage	liaemorrhage	NN
cord-015021-pol2qm74	3831	20	and	and	CC
cord-015021-pol2qm74	3831	21	rAnerfn	rAnerfn	NNP
cord-015021-pol2qm74	3831	22	~	~	NFP
cord-015021-pol2qm74	3831	23	ion	ion	NN
cord-015021-pol2qm74	3831	24	.	.	.
cord-015021-pol2qm74	3832	1	Thermal	thermal	JJ
cord-015021-pol2qm74	3832	2	injuries	injury	NNS
cord-015021-pol2qm74	3832	3	and	and	CC
cord-015021-pol2qm74	3832	4	systemic	systemic	JJ
cord-015021-pol2qm74	3832	5	bacterial	bacterial	JJ
cord-015021-pol2qm74	3832	6	sepsis	sepsis	NN
cord-015021-pol2qm74	3832	7	produce	produce	VBP
cord-015021-pol2qm74	3832	8	a	a	DT
cord-015021-pol2qm74	3832	9	wasting	waste	VBG
cord-015021-pol2qm74	3832	10	diathesis	diathesis	NN
cord-015021-pol2qm74	3832	11	with	with	IN
cord-015021-pol2qm74	3832	12	anorexia	anorexia	NN
cord-015021-pol2qm74	3832	13	and	and	CC
cord-015021-pol2qm74	3832	14	marked	marked	JJ
cord-015021-pol2qm74	3832	15	loss	loss	NN
cord-015021-pol2qm74	3832	16	of	of	IN
cord-015021-pol2qm74	3832	17	lean	lean	JJ
cord-015021-pol2qm74	3832	18	tissue	tissue	NN
cord-015021-pol2qm74	3832	19	and	and	CC
cord-015021-pol2qm74	3832	20	body	body	NN
cord-015021-pol2qm74	3832	21	fat	fat	NN
cord-015021-pol2qm74	3832	22	.	.	.
cord-015021-pol2qm74	3833	1	Endogenously	Endogenously	NNP
cord-015021-pol2qm74	3833	2	produced	produce	VBD
cord-015021-pol2qm74	3833	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	3833	4	,	,	,
cord-015021-pol2qm74	3833	5	including	include	VBG
cord-015021-pol2qm74	3833	6	interleukin-1	interleukin-1	NN
cord-015021-pol2qm74	3833	7	(	(	-LRB-
cord-015021-pol2qm74	3833	8	IL-1	IL-1	NNP
cord-015021-pol2qm74	3833	9	)	)	-RRB-
cord-015021-pol2qm74	3833	10	,	,	,
cord-015021-pol2qm74	3833	11	are	be	VBP
cord-015021-pol2qm74	3833	12	thought	think	VBN
cord-015021-pol2qm74	3833	13	to	to	TO
cord-015021-pol2qm74	3833	14	mediate	mediate	VB
cord-015021-pol2qm74	3833	15	many	many	JJ
cord-015021-pol2qm74	3833	16	beneficial	beneficial	JJ
cord-015021-pol2qm74	3833	17	as	as	RB
cord-015021-pol2qm74	3833	18	well	well	RB
cord-015021-pol2qm74	3833	19	as	as	IN
cord-015021-pol2qm74	3833	20	pathologic	pathologic	JJ
cord-015021-pol2qm74	3833	21	host	host	NN
cord-015021-pol2qm74	3833	22	changes	change	NNS
cord-015021-pol2qm74	3833	23	that	that	WDT
cord-015021-pol2qm74	3833	24	occur	occur	VBP
cord-015021-pol2qm74	3833	25	during	during	IN
cord-015021-pol2qm74	3833	26	burn	burn	NN
cord-015021-pol2qm74	3833	27	injury	injury	NN
cord-015021-pol2qm74	3833	28	and	and	CC
cord-015021-pol2qm74	3833	29	infection	infection	NN
cord-015021-pol2qm74	3833	30	.	.	.
cord-015021-pol2qm74	3834	1	To	to	TO
cord-015021-pol2qm74	3834	2	evaluate	evaluate	VB
cord-015021-pol2qm74	3834	3	whether	whether	IN
cord-015021-pol2qm74	3834	4	bluckade	bluckade	NN
cord-015021-pol2qm74	3834	5	of	of	IN
cord-015021-pol2qm74	3834	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	3834	7	in	in	IN
cord-015021-pol2qm74	3834	8	vivo	vivo	NN
cord-015021-pol2qm74	3834	9	would	would	MD
cord-015021-pol2qm74	3834	10	affect	affect	VB
cord-015021-pol2qm74	3834	11	survival	survival	NN
cord-015021-pol2qm74	3834	12	and	and	CC
cord-015021-pol2qm74	3834	13	attenuate	attenuate	VB
cord-015021-pol2qm74	3834	14	the	the	DT
cord-015021-pol2qm74	3834	15	anorexia	anorexia	NN
cord-015021-pol2qm74	3834	16	and	and	CC
cord-015021-pol2qm74	3834	17	cachex[a	cachex[a	NNP
cord-015021-pol2qm74	3834	18	associated	associate	VBD
cord-015021-pol2qm74	3834	19	with	with	IN
cord-015021-pol2qm74	3834	20	a	a	DT
cord-015021-pol2qm74	3834	21	thermal	thermal	JJ
cord-015021-pol2qm74	3834	22	injury	injury	NN
cord-015021-pol2qm74	3834	23	and	and	CC
cord-015021-pol2qm74	3834	24	chronic	chronic	JJ
cord-015021-pol2qm74	3834	25	fulminant	fulminant	JJ
cord-015021-pol2qm74	3834	26	gram	gram	NN
cord-015021-pol2qm74	3834	27	negative	negative	JJ
cord-015021-pol2qm74	3834	28	infection	infection	NN
cord-015021-pol2qm74	3834	29	,	,	,
cord-015021-pol2qm74	3834	30	24	24	CD
cord-015021-pol2qm74	3834	31	Sprague	Sprague	NNP
cord-015021-pol2qm74	3834	32	-	-	HYPH
cord-015021-pol2qm74	3834	33	Dawley	Dawley	NNP
cord-015021-pol2qm74	3834	34	rats	rat	NNS
cord-015021-pol2qm74	3834	35	were	be	VBD
cord-015021-pol2qm74	3834	36	studied	study	VBN
cord-015021-pol2qm74	3834	37	.	.	.
cord-015021-pol2qm74	3835	1	Anesthetized	anesthetized	JJ
cord-015021-pol2qm74	3835	2	rats	rat	NNS
cord-015021-pol2qm74	3835	3	were	be	VBD
cord-015021-pol2qm74	3835	4	divided	divide	VBN
cord-015021-pol2qm74	3835	5	in	in	IN
cord-015021-pol2qm74	3835	6	3	3	CD
cord-015021-pol2qm74	3835	7	groups	group	NNS
cord-015021-pol2qm74	3835	8	,	,	,
cord-015021-pol2qm74	3835	9	implanted	implant	VBN
cord-015021-pol2qm74	3835	10	with	with	IN
cord-015021-pol2qm74	3835	11	Alzet	Alzet	NNP
cord-015021-pol2qm74	3835	12	R	R	NNP
cord-015021-pol2qm74	3835	13	minipumps	minipump	NNS
cord-015021-pol2qm74	3835	14	and	and	CC
cord-015021-pol2qm74	3835	15	randomized	randomize	VBD
cord-015021-pol2qm74	3835	16	to	to	TO
cord-015021-pol2qm74	3835	17	receive	receive	VB
cord-015021-pol2qm74	3835	18	the	the	DT
cord-015021-pol2qm74	3835	19	following	following	JJ
cord-015021-pol2qm74	3835	20	treatment	treatment	NN
cord-015021-pol2qm74	3835	21	for	for	IN
cord-015021-pol2qm74	3835	22	14	14	CD
cord-015021-pol2qm74	3835	23	days	day	NNS
cord-015021-pol2qm74	3835	24	:	:	:
cord-015021-pol2qm74	3835	25	i	i	PRP
cord-015021-pol2qm74	3835	26	:	:	:
cord-015021-pol2qm74	3835	27	25	25	CD
cord-015021-pol2qm74	3835	28	gg	gg	NNP
cord-015021-pol2qm74	3835	29	/	/	SYM
cord-015021-pol2qm74	3835	30	kgBW	kgBW	NNP
cord-015021-pol2qm74	3835	31	/	/	SYM
cord-015021-pol2qm74	3835	32	min	min	NNP
cord-015021-pol2qm74	3835	33	of	of	IN
cord-015021-pol2qm74	3835	34	IL	IL	NNP
cord-015021-pol2qm74	3835	35	-	-	HYPH
cord-015021-pol2qm74	3835	36	lcc	lcc	NNP
cord-015021-pol2qm74	3835	37	;	;	:
cord-015021-pol2qm74	3835	38	II	II	NNP
cord-015021-pol2qm74	3835	39	:	:	:
cord-015021-pol2qm74	3835	40	25	25	CD
cord-015021-pol2qm74	3835	41	~tg	~tg	NNS
cord-015021-pol2qm74	3835	42	/	/	SYM
cord-015021-pol2qm74	3835	43	kgBW	kgBW	NNP
cord-015021-pol2qm74	3835	44	/	/	SYM
cord-015021-pol2qm74	3835	45	min	min	NN
cord-015021-pol2qm74	3835	46	of	of	IN
cord-015021-pol2qm74	3835	47	IL-1	IL-1	NNP
cord-015021-pol2qm74	3835	48	receptor	receptor	NN
cord-015021-pol2qm74	3835	49	antagonist	antagonist	NN
cord-015021-pol2qm74	3835	50	(	(	-LRB-
cord-015021-pol2qm74	3835	51	IL	IL	NNP
cord-015021-pol2qm74	3835	52	-	-	HYPH
cord-015021-pol2qm74	3835	53	Ira	Ira	NNP
cord-015021-pol2qm74	3835	54	)	)	-RRB-
cord-015021-pol2qm74	3835	55	;	;	:
cord-015021-pol2qm74	3835	56	III	III	NNP
cord-015021-pol2qm74	3835	57	:	:	:
cord-015021-pol2qm74	3835	58	buffered	buffer	VBN
cord-015021-pol2qm74	3835	59	vehicle	vehicle	NN
cord-015021-pol2qm74	3835	60	.	.	.
cord-015021-pol2qm74	3836	1	The	the	DT
cord-015021-pol2qm74	3836	2	animals	animal	NNS
cord-015021-pol2qm74	3836	3	were	be	VBD
cord-015021-pol2qm74	3836	4	subjected	subject	VBN
cord-015021-pol2qm74	3836	5	to	to	IN
cord-015021-pol2qm74	3836	6	a	a	DT
cord-015021-pol2qm74	3836	7	30	30	CD
cord-015021-pol2qm74	3836	8	%	%	NN
cord-015021-pol2qm74	3836	9	BSA	BSA	NNP
cord-015021-pol2qm74	3836	10	,	,	,
cord-015021-pol2qm74	3836	11	full	full	JJ
cord-015021-pol2qm74	3836	12	thickness	thickness	NN
cord-015021-pol2qm74	3836	13	scald	scald	NN
cord-015021-pol2qm74	3836	14	burn	burn	VB
cord-015021-pol2qm74	3836	15	and	and	CC
cord-015021-pol2qm74	3836	16	the	the	DT
cord-015021-pol2qm74	3836	17	wounds	wound	NNS
cord-015021-pol2qm74	3836	18	then	then	RB
cord-015021-pol2qm74	3836	19	infected	infect	VBN
cord-015021-pol2qm74	3836	20	with	with	IN
cord-015021-pol2qm74	3836	21	10	10	CD
cord-015021-pol2qm74	3836	22	+	+	NNS
cord-015021-pol2qm74	3836	23	cfu	cfu	NN
cord-015021-pol2qm74	3836	24	/	/	SYM
cord-015021-pol2qm74	3836	25	mL	mL	NNP
cord-015021-pol2qm74	3836	26	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	3836	27	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	3836	28	.	.	.
cord-015021-pol2qm74	3837	1	Eight	eight	CD
cord-015021-pol2qm74	3837	2	additional	additional	JJ
cord-015021-pol2qm74	3837	3	rats	rat	NNS
cord-015021-pol2qm74	3837	4	were	be	VBD
cord-015021-pol2qm74	3837	5	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	3837	6	,	,	,
cord-015021-pol2qm74	3837	7	but	but	CC
cord-015021-pol2qm74	3837	8	were	be	VBD
cord-015021-pol2qm74	3837	9	not	not	RB
cord-015021-pol2qm74	3837	10	burned	burn	VBN
cord-015021-pol2qm74	3837	11	,	,	,
cord-015021-pol2qm74	3837	12	and	and	CC
cord-015021-pol2qm74	3837	13	served	serve	VBD
cord-015021-pol2qm74	3837	14	as	as	IN
cord-015021-pol2qm74	3837	15	healthy	healthy	JJ
cord-015021-pol2qm74	3837	16	controls	control	NNS
cord-015021-pol2qm74	3837	17	.	.	.
cord-015021-pol2qm74	3837	18	.	.	.
cord-015021-pol2qm74	3838	1	IL	IL	NNP
cord-015021-pol2qm74	3838	2	-	-	HYPH
cord-015021-pol2qm74	3838	3	hx	hx	NNP
cord-015021-pol2qm74	3838	4	reduced	reduce	VBN
cord-015021-pol2qm74	3838	5	food	food	NN
cord-015021-pol2qm74	3838	6	intake	intake	NN
cord-015021-pol2qm74	3838	7	transiently	transiently	RB
cord-015021-pol2qm74	3838	8	but	but	CC
cord-015021-pol2qm74	3838	9	was	be	VBD
cord-015021-pol2qm74	3838	10	otherwise	otherwise	RB
cord-015021-pol2qm74	3838	11	without	without	IN
cord-015021-pol2qm74	3838	12	effect	effect	NN
cord-015021-pol2qm74	3838	13	However	however	RB
cord-015021-pol2qm74	3838	14	,	,	,
cord-015021-pol2qm74	3838	15	IL	IL	NNP
cord-015021-pol2qm74	3838	16	-	-	HYPH
cord-015021-pol2qm74	3838	17	lra	lra	NNP
cord-015021-pol2qm74	3838	18	significantly	significantly	RB
cord-015021-pol2qm74	3838	19	attenuated	attenuate	VBD
cord-015021-pol2qm74	3838	20	weight	weight	NN
cord-015021-pol2qm74	3838	21	loss	loss	NN
cord-015021-pol2qm74	3838	22	over	over	IN
cord-015021-pol2qm74	3838	23	the	the	DT
cord-015021-pol2qm74	3838	24	first	first	JJ
cord-015021-pol2qm74	3838	25	8	8	CD
cord-015021-pol2qm74	3838	26	days	day	NNS
cord-015021-pol2qm74	3838	27	and	and	CC
cord-015021-pol2qm74	3838	28	improved	improve	VBN
cord-015021-pol2qm74	3838	29	food	food	NN
cord-015021-pol2qm74	3838	30	intake	intake	NN
cord-015021-pol2qm74	3838	31	between	between	IN
cord-015021-pol2qm74	3838	32	days	day	NNS
cord-015021-pol2qm74	3838	33	5	5	CD
cord-015021-pol2qm74	3838	34	and	and	CC
cord-015021-pol2qm74	3838	35	8	8	CD
cord-015021-pol2qm74	3838	36	.	.	.
cord-015021-pol2qm74	3839	1	We	-PRON-	PRP
cord-015021-pol2qm74	3839	2	conclude	conclude	VBP
cord-015021-pol2qm74	3839	3	that	that	IN
cord-015021-pol2qm74	3839	4	blockade	blockade	NN
cord-015021-pol2qm74	3839	5	of	of	IN
cord-015021-pol2qm74	3839	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	3839	7	after	after	IN
cord-015021-pol2qm74	3839	8	a	a	DT
cord-015021-pol2qm74	3839	9	thermal	thermal	JJ
cord-015021-pol2qm74	3839	10	injury	injury	NN
cord-015021-pol2qm74	3839	11	with	with	IN
cord-015021-pol2qm74	3839	12	superimposed	superimpose	VBN
cord-015021-pol2qm74	3839	13	infection	infection	NN
cord-015021-pol2qm74	3839	14	does	do	VBZ
cord-015021-pol2qm74	3839	15	not	not	RB
cord-015021-pol2qm74	3839	16	adversly	adversly	RB
cord-015021-pol2qm74	3839	17	affect	affect	VB
cord-015021-pol2qm74	3839	18	the	the	DT
cord-015021-pol2qm74	3839	19	progression	progression	NN
cord-015021-pol2qm74	3839	20	of	of	IN
cord-015021-pol2qm74	3839	21	the	the	DT
cord-015021-pol2qm74	3839	22	disease	disease	NN
cord-015021-pol2qm74	3839	23	,	,	,
cord-015021-pol2qm74	3839	24	but	but	CC
cord-015021-pol2qm74	3839	25	does	do	VBZ
cord-015021-pol2qm74	3839	26	attenuate	attenuate	VB
cord-015021-pol2qm74	3839	27	the	the	DT
cord-015021-pol2qm74	3839	28	anorexia	anorexia	NN
cord-015021-pol2qm74	3839	29	and	and	CC
cord-015021-pol2qm74	3839	30	weight	weight	NN
cord-015021-pol2qm74	3839	31	loss	loss	NN
cord-015021-pol2qm74	3839	32	associated	associate	VBN
cord-015021-pol2qm74	3839	33	with	with	IN
cord-015021-pol2qm74	3839	34	this	this	DT
cord-015021-pol2qm74	3839	35	model	model	NN
cord-015021-pol2qm74	3839	36	.	.	.
cord-015021-pol2qm74	3840	1	These	these	DT
cord-015021-pol2qm74	3840	2	data	datum	NNS
cord-015021-pol2qm74	3840	3	indicate	indicate	VBP
cord-015021-pol2qm74	3840	4	that	that	IN
cord-015021-pol2qm74	3840	5	IL	IL	NNP
cord-015021-pol2qm74	3840	6	-	-	HYPH
cord-015021-pol2qm74	3840	7	I	i	NN
cord-015021-pol2qm74	3840	8	receptor	receptor	NN
cord-015021-pol2qm74	3840	9	blockade	blockade	NN
cord-015021-pol2qm74	3840	10	may	may	MD
cord-015021-pol2qm74	3840	11	offer	offer	VB
cord-015021-pol2qm74	3840	12	a	a	DT
cord-015021-pol2qm74	3840	13	means	means	NN
cord-015021-pol2qm74	3840	14	to	to	TO
cord-015021-pol2qm74	3840	15	minimize	minimize	VB
cord-015021-pol2qm74	3840	16	the	the	DT
cord-015021-pol2qm74	3840	17	morbidity	morbidity	NN
cord-015021-pol2qm74	3840	18	associated	associate	VBN
cord-015021-pol2qm74	3840	19	with	with	IN
cord-015021-pol2qm74	3840	20	catabolic	catabolic	JJ
cord-015021-pol2qm74	3840	21	illness	illness	NN
cord-015021-pol2qm74	3840	22	.	.	.
cord-015021-pol2qm74	3841	1	Tumor	tumor	NN
cord-015021-pol2qm74	3841	2	necrosis	necrosis	NN
cord-015021-pol2qm74	3841	3	factor	factor	NN
cord-015021-pol2qm74	3841	4	(	(	-LRB-
cord-015021-pol2qm74	3841	5	TNF	TNF	NNP
cord-015021-pol2qm74	3841	6	)	)	-RRB-
cord-015021-pol2qm74	3841	7	and	and	CC
cord-015021-pol2qm74	3841	8	its	-PRON-	PRP$
cord-015021-pol2qm74	3841	9	downstream	downstream	NN
cord-015021-pol2qm74	3841	10	induced	induce	VBN
cord-015021-pol2qm74	3841	11	mediators	mediator	NNS
cord-015021-pol2qm74	3841	12	have	have	VBP
cord-015021-pol2qm74	3841	13	pivotal	pivotal	JJ
cord-015021-pol2qm74	3841	14	roles	role	NNS
cord-015021-pol2qm74	3841	15	in	in	IN
cord-015021-pol2qm74	3841	16	the	the	DT
cord-015021-pol2qm74	3841	17	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	3841	18	of	of	IN
cord-015021-pol2qm74	3841	19	sepsis	sepsis	NN
cord-015021-pol2qm74	3841	20	and	and	CC
cord-015021-pol2qm74	3841	21	septic	septic	JJ
cord-015021-pol2qm74	3841	22	shock	shock	NN
cord-015021-pol2qm74	3841	23	.	.	.
cord-015021-pol2qm74	3842	1	The	the	DT
cord-015021-pol2qm74	3842	2	suppressive	suppressive	JJ
cord-015021-pol2qm74	3842	3	effect	effect	NN
cord-015021-pol2qm74	3842	4	of	of	IN
cord-015021-pol2qm74	3842	5	pentoxyfillin	pentoxyfillin	NN
cord-015021-pol2qm74	3842	6	(	(	-LRB-
cord-015021-pol2qm74	3842	7	PTX	PTX	NNP
cord-015021-pol2qm74	3842	8	)	)	-RRB-
cord-015021-pol2qm74	3842	9	on	on	IN
cord-015021-pol2qm74	3842	10	TNF	TNF	NNP
cord-015021-pol2qm74	3842	11	production	production	NN
cord-015021-pol2qm74	3842	12	may	may	MD
cord-015021-pol2qm74	3842	13	be	be	VB
cord-015021-pol2qm74	3842	14	of	of	IN
cord-015021-pol2qm74	3842	15	clinical	clinical	JJ
cord-015021-pol2qm74	3842	16	importance	importance	NN
cord-015021-pol2qm74	3842	17	.	.	.
cord-015021-pol2qm74	3843	1	When	when	WRB
cord-015021-pol2qm74	3843	2	peripheral	peripheral	JJ
cord-015021-pol2qm74	3843	3	white	white	JJ
cord-015021-pol2qm74	3843	4	blood	blood	NN
cord-015021-pol2qm74	3843	5	ceils	ceil	NNS
cord-015021-pol2qm74	3843	6	were	be	VBD
cord-015021-pol2qm74	3843	7	stimulated	stimulate	VBN
cord-015021-pol2qm74	3843	8	with	with	IN
cord-015021-pol2qm74	3843	9	either	either	DT
cord-015021-pol2qm74	3843	10	LPS	LPS	NNP
cord-015021-pol2qm74	3843	11	or	or	CC
cord-015021-pol2qm74	3843	12	Staphylococcus	Staphylococcus	NNP
cord-015021-pol2qm74	3843	13	aureus	aureus	NN
cord-015021-pol2qm74	3843	14	,	,	,
cord-015021-pol2qm74	3843	15	pentoxyfillin	pentoxyfillin	NNP
cord-015021-pol2qm74	3843	16	inhibited	inhibit	VBN
cord-015021-pol2qm74	3843	17	TNF	TNF	NNP
cord-015021-pol2qm74	3843	18	production	production	NN
cord-015021-pol2qm74	3843	19	.	.	.
cord-015021-pol2qm74	3844	1	In	in	IN
cord-015021-pol2qm74	3844	2	contrast	contrast	NN
cord-015021-pol2qm74	3844	3	,	,	,
cord-015021-pol2qm74	3844	4	no	no	DT
cord-015021-pol2qm74	3844	5	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	3844	6	effect	effect	NN
cord-015021-pol2qm74	3844	7	was	be	VBD
cord-015021-pol2qm74	3844	8	observed	observe	VBN
cord-015021-pol2qm74	3844	9	on	on	IN
cord-015021-pol2qm74	3844	10	the	the	DT
cord-015021-pol2qm74	3844	11	induction	induction	NN
cord-015021-pol2qm74	3844	12	of	of	IN
cord-015021-pol2qm74	3844	13	IL-6	IL-6	NNP
cord-015021-pol2qm74	3844	14	.	.	.
cord-015021-pol2qm74	3845	1	PTX	PTX	NNP
cord-015021-pol2qm74	3845	2	inhibited	inhibit	VBD
cord-015021-pol2qm74	3845	3	not	not	RB
cord-015021-pol2qm74	3845	4	only	only	RB
cord-015021-pol2qm74	3845	5	the	the	DT
cord-015021-pol2qm74	3845	6	TNF	TNF	NNP
cord-015021-pol2qm74	3845	7	production	production	NN
cord-015021-pol2qm74	3845	8	of	of	IN
cord-015021-pol2qm74	3845	9	monocytes	monocyte	NNS
cord-015021-pol2qm74	3845	10	but	but	CC
cord-015021-pol2qm74	3845	11	also	also	RB
cord-015021-pol2qm74	3845	12	the	the	DT
cord-015021-pol2qm74	3845	13	TNF	TNF	NNP
cord-015021-pol2qm74	3845	14	secretion	secretion	NN
cord-015021-pol2qm74	3845	15	of	of	IN
cord-015021-pol2qm74	3845	16	both	both	DT
cord-015021-pol2qm74	3845	17	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	3845	18	,	,	,
cord-015021-pol2qm74	3845	19	and	and	CC
cord-015021-pol2qm74	3845	20	unseparated	unseparated	JJ
cord-015021-pol2qm74	3845	21	whole	whole	JJ
cord-015021-pol2qm74	3845	22	blood	blood	NN
cord-015021-pol2qm74	3845	23	.	.	.
cord-015021-pol2qm74	3846	1	The	the	DT
cord-015021-pol2qm74	3846	2	FACS	FACS	NNP
cord-015021-pol2qm74	3846	3	analysis	analysis	NN
cord-015021-pol2qm74	3846	4	revealed	reveal	VBD
cord-015021-pol2qm74	3846	5	that	that	IN
cord-015021-pol2qm74	3846	6	the	the	DT
cord-015021-pol2qm74	3846	7	expression	expression	NN
cord-015021-pol2qm74	3846	8	of	of	IN
cord-015021-pol2qm74	3846	9	CD14	CD14	NNP
cord-015021-pol2qm74	3846	10	antigen	antigen	NN
cord-015021-pol2qm74	3846	11	on	on	IN
cord-015021-pol2qm74	3846	12	monocytes	monocyte	NNS
cord-015021-pol2qm74	3846	13	was	be	VBD
cord-015021-pol2qm74	3846	14	not	not	RB
cord-015021-pol2qm74	3846	15	influenced	influence	VBN
cord-015021-pol2qm74	3846	16	by	by	IN
cord-015021-pol2qm74	3846	17	pentoxyfillin	pentoxyfillin	NNP
cord-015021-pol2qm74	3846	18	.	.	.
cord-015021-pol2qm74	3847	1	The	the	DT
cord-015021-pol2qm74	3847	2	in	in	FW
cord-015021-pol2qm74	3847	3	vitro	vitro	FW
cord-015021-pol2qm74	3847	4	TNF	TNF	NNP
cord-015021-pol2qm74	3847	5	and	and	CC
cord-015021-pol2qm74	3847	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	3847	7	producing	produce	VBG
cord-015021-pol2qm74	3847	8	capacity	capacity	NN
cord-015021-pol2qm74	3847	9	in	in	IN
cord-015021-pol2qm74	3847	10	septic	septic	JJ
cord-015021-pol2qm74	3847	11	patients	patient	NNS
cord-015021-pol2qm74	3847	12	were	be	VBD
cord-015021-pol2qm74	3847	13	higher	high	JJR
cord-015021-pol2qm74	3847	14	than	than	IN
cord-015021-pol2qm74	3847	15	in	in	IN
cord-015021-pol2qm74	3847	16	the	the	DT
cord-015021-pol2qm74	3847	17	control	control	NN
cord-015021-pol2qm74	3847	18	group	group	NN
cord-015021-pol2qm74	3847	19	,	,	,
cord-015021-pol2qm74	3847	20	but	but	CC
cord-015021-pol2qm74	3847	21	decreased	decrease	VBD
cord-015021-pol2qm74	3847	22	on	on	IN
cord-015021-pol2qm74	3847	23	subsequent	subsequent	JJ
cord-015021-pol2qm74	3847	24	days	day	NNS
cord-015021-pol2qm74	3847	25	especially	especially	RB
cord-015021-pol2qm74	3847	26	in	in	IN
cord-015021-pol2qm74	3847	27	fatal	fatal	JJ
cord-015021-pol2qm74	3847	28	cases	case	NNS
cord-015021-pol2qm74	3847	29	.	.	.
cord-015021-pol2qm74	3848	1	Administration	Administration	NNP
cord-015021-pol2qm74	3848	2	of	of	IN
cord-015021-pol2qm74	3848	3	PTX	PTX	NNP
cord-015021-pol2qm74	3848	4	(	(	-LRB-
cord-015021-pol2qm74	3848	5	200	200	CD
cord-015021-pol2qm74	3848	6	mg	mg	NNP
cord-015021-pol2qm74	3848	7	/	/	SYM
cord-015021-pol2qm74	3848	8	day	day	NN
cord-015021-pol2qm74	3848	9	)	)	-RRB-
cord-015021-pol2qm74	3848	10	in	in	IN
cord-015021-pol2qm74	3848	11	septic	septic	JJ
cord-015021-pol2qm74	3848	12	patients	patient	NNS
cord-015021-pol2qm74	3848	13	resulted	result	VBD
cord-015021-pol2qm74	3848	14	in	in	IN
cord-015021-pol2qm74	3848	15	TNF	TNF	NNP
cord-015021-pol2qm74	3848	16	and	and	CC
cord-015021-pol2qm74	3848	17	IL-6	IL-6	NNP
cord-015021-pol2qm74	3848	18	productions	production	NNS
cord-015021-pol2qm74	3848	19	similar	similar	JJ
cord-015021-pol2qm74	3848	20	to	to	IN
cord-015021-pol2qm74	3848	21	those	those	DT
cord-015021-pol2qm74	3848	22	found	find	VBN
cord-015021-pol2qm74	3848	23	in	in	IN
cord-015021-pol2qm74	3848	24	control	control	NN
cord-015021-pol2qm74	3848	25	donors	donor	NNS
cord-015021-pol2qm74	3848	26	.	.	.
cord-015021-pol2qm74	3849	1	It	-PRON-	PRP
cord-015021-pol2qm74	3849	2	also	also	RB
cord-015021-pol2qm74	3849	3	subsequently	subsequently	RB
cord-015021-pol2qm74	3849	4	led	lead	VBD
cord-015021-pol2qm74	3849	5	to	to	IN
cord-015021-pol2qm74	3849	6	an	an	DT
cord-015021-pol2qm74	3849	7	improvement	improvement	NN
cord-015021-pol2qm74	3849	8	of	of	IN
cord-015021-pol2qm74	3849	9	the	the	DT
cord-015021-pol2qm74	3849	10	clinical	clinical	JJ
cord-015021-pol2qm74	3849	11	status	status	NN
cord-015021-pol2qm74	3849	12	.	.	.
cord-015021-pol2qm74	3850	1	A	a	DT
cord-015021-pol2qm74	3850	2	further	further	JJ
cord-015021-pol2qm74	3850	3	improvement	improvement	NN
cord-015021-pol2qm74	3850	4	in	in	IN
cord-015021-pol2qm74	3850	5	APACHE	APACHE	NNP
cord-015021-pol2qm74	3850	6	score	score	NN
cord-015021-pol2qm74	3850	7	could	could	MD
cord-015021-pol2qm74	3850	8	be	be	VB
cord-015021-pol2qm74	3850	9	achieved	achieve	VBN
cord-015021-pol2qm74	3850	10	by	by	IN
cord-015021-pol2qm74	3850	11	administration	administration	NN
cord-015021-pol2qm74	3850	12	of	of	IN
cord-015021-pol2qm74	3850	13	Pentaglobin	Pentaglobin	NNP
cord-015021-pol2qm74	3850	14	°	°	NNP
cord-015021-pol2qm74	3851	1	(	(	-LRB-
cord-015021-pol2qm74	3851	2	Biotest	Biotest	NNP
cord-015021-pol2qm74	3851	3	)	)	-RRB-
cord-015021-pol2qm74	3852	1	(	(	-LRB-
cord-015021-pol2qm74	3852	2	5ml	5ml	NNS
cord-015021-pol2qm74	3852	3	/	/	SYM
cord-015021-pol2qm74	3852	4	kg	kg	NN
cord-015021-pol2qm74	3852	5	/	/	SYM
cord-015021-pol2qm74	3852	6	day	day	NN
cord-015021-pol2qm74	3852	7	)	)	-RRB-
cord-015021-pol2qm74	3852	8	.	.	.
cord-015021-pol2qm74	3853	1	The	the	DT
cord-015021-pol2qm74	3853	2	prevention	prevention	NN
cord-015021-pol2qm74	3853	3	of	of	IN
cord-015021-pol2qm74	3853	4	LPSinduced	LPSinduced	NNP
cord-015021-pol2qm74	3853	5	in	in	IN
cord-015021-pol2qm74	3853	6	vitro	vitro	FW
cord-015021-pol2qm74	3853	7	TNF	TNF	NNP
cord-015021-pol2qm74	3853	8	and	and	CC
cord-015021-pol2qm74	3853	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	3853	10	production	production	NN
cord-015021-pol2qm74	3853	11	by	by	IN
cord-015021-pol2qm74	3853	12	Pentaglobin	Pentaglobin	NNP
cord-015021-pol2qm74	3853	13	°	°	NN
cord-015021-pol2qm74	3853	14	could	could	MD
cord-015021-pol2qm74	3853	15	be	be	VB
cord-015021-pol2qm74	3853	16	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	3853	17	in	in	IN
cord-015021-pol2qm74	3853	18	in	in	IN
cord-015021-pol2qm74	3853	19	vitro	vitro	FW
cord-015021-pol2qm74	3853	20	experiments	experiment	NNS
cord-015021-pol2qm74	3853	21	involving	involve	VBG
cord-015021-pol2qm74	3853	22	the	the	DT
cord-015021-pol2qm74	3853	23	use	use	NN
cord-015021-pol2qm74	3853	24	of	of	IN
cord-015021-pol2qm74	3853	25	whole	whole	JJ
cord-015021-pol2qm74	3853	26	blood	blood	NN
cord-015021-pol2qm74	3853	27	rather	rather	RB
cord-015021-pol2qm74	3853	28	than	than	IN
cord-015021-pol2qm74	3853	29	purified	purify	VBN
cord-015021-pol2qm74	3853	30	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	3853	31	,	,	,
cord-015021-pol2qm74	3853	32	very	very	RB
cord-015021-pol2qm74	3853	33	probably	probably	RB
cord-015021-pol2qm74	3853	34	because	because	IN
cord-015021-pol2qm74	3853	35	of	of	IN
cord-015021-pol2qm74	3853	36	the	the	DT
cord-015021-pol2qm74	3853	37	presence	presence	NN
cord-015021-pol2qm74	3853	38	of	of	IN
cord-015021-pol2qm74	3853	39	LPS	LPS	NNP
cord-015021-pol2qm74	3853	40	binding	bind	VBG
cord-015021-pol2qm74	3853	41	protein	protein	NN
cord-015021-pol2qm74	3853	42	in	in	IN
cord-015021-pol2qm74	3853	43	the	the	DT
cord-015021-pol2qm74	3853	44	plasma	plasma	NN
cord-015021-pol2qm74	3853	45	.	.	.
cord-015021-pol2qm74	3854	1	The	the	DT
cord-015021-pol2qm74	3854	2	level	level	NN
cord-015021-pol2qm74	3854	3	of	of	IN
cord-015021-pol2qm74	3854	4	soluble	soluble	JJ
cord-015021-pol2qm74	3854	5	ICAM-1	icam-1	NN
cord-015021-pol2qm74	3854	6	in	in	IN
cord-015021-pol2qm74	3854	7	sera	sera	NNP
cord-015021-pol2qm74	3854	8	of	of	IN
cord-015021-pol2qm74	3854	9	septic	septic	JJ
cord-015021-pol2qm74	3854	10	patients	patient	NNS
cord-015021-pol2qm74	3854	11	was	be	VBD
cord-015021-pol2qm74	3854	12	significantly	significantly	RB
cord-015021-pol2qm74	3854	13	higher	high	JJR
cord-015021-pol2qm74	3854	14	(	(	-LRB-
cord-015021-pol2qm74	3854	15	800	800	CD
cord-015021-pol2qm74	3854	16	-	-	CD
cord-015021-pol2qm74	3854	17	1200	1200	CD
cord-015021-pol2qm74	3854	18	ng	ng	NN
cord-015021-pol2qm74	3854	19	/	/	SYM
cord-015021-pol2qm74	3854	20	ml	ml	NNP
cord-015021-pol2qm74	3854	21	)	)	-RRB-
cord-015021-pol2qm74	3854	22	than	than	IN
cord-015021-pol2qm74	3854	23	in	in	IN
cord-015021-pol2qm74	3854	24	normal	normal	JJ
cord-015021-pol2qm74	3854	25	individuals	individual	NNS
cord-015021-pol2qm74	3854	26	(	(	-LRB-
cord-015021-pol2qm74	3854	27	50	50	CD
cord-015021-pol2qm74	3854	28	-	-	SYM
cord-015021-pol2qm74	3854	29	150	150	CD
cord-015021-pol2qm74	3854	30	ng	ng	NN
cord-015021-pol2qm74	3854	31	/	/	SYM
cord-015021-pol2qm74	3854	32	ml	ml	NN
cord-015021-pol2qm74	3854	33	)	)	-RRB-
cord-015021-pol2qm74	3854	34	,	,	,
cord-015021-pol2qm74	3854	35	but	but	CC
cord-015021-pol2qm74	3854	36	it	-PRON-	PRP
cord-015021-pol2qm74	3854	37	decreased	decrease	VBD
cord-015021-pol2qm74	3854	38	following	follow	VBG
cord-015021-pol2qm74	3854	39	the	the	DT
cord-015021-pol2qm74	3854	40	PTX	PTX	NNP
cord-015021-pol2qm74	3854	41	and	and	CC
cord-015021-pol2qm74	3854	42	Pentaglobin	Pentaglobin	NNP
cord-015021-pol2qm74	3854	43	°	°	NN
cord-015021-pol2qm74	3854	44	therapy	therapy	NN
cord-015021-pol2qm74	3854	45	.	.	.
cord-015021-pol2qm74	3855	1	It	-PRON-	PRP
cord-015021-pol2qm74	3855	2	is	be	VBZ
cord-015021-pol2qm74	3855	3	presumed	presume	VBN
cord-015021-pol2qm74	3855	4	that	that	IN
cord-015021-pol2qm74	3855	5	PTX	PTX	NNP
cord-015021-pol2qm74	3855	6	and	and	CC
cord-015021-pol2qm74	3855	7	Pentaglobin	Pentaglobin	NNP
cord-015021-pol2qm74	3855	8	°	°	NN
cord-015021-pol2qm74	3855	9	can	can	MD
cord-015021-pol2qm74	3855	10	antagonize	antagonize	VB
cord-015021-pol2qm74	3855	11	eytokine	eytokine	JJ
cord-015021-pol2qm74	3855	12	production	production	NN
cord-015021-pol2qm74	3855	13	at	at	IN
cord-015021-pol2qm74	3855	14	different	different	JJ
cord-015021-pol2qm74	3855	15	levels	level	NNS
cord-015021-pol2qm74	3855	16	,	,	,
cord-015021-pol2qm74	3855	17	resulting	result	VBG
cord-015021-pol2qm74	3855	18	synergistic	synergistic	JJ
cord-015021-pol2qm74	3855	19	action	action	NN
cord-015021-pol2qm74	3855	20	being	be	VBG
cord-015021-pol2qm74	3855	21	beneficial	beneficial	JJ
cord-015021-pol2qm74	3855	22	in	in	IN
cord-015021-pol2qm74	3855	23	the	the	DT
cord-015021-pol2qm74	3855	24	treatment	treatment	NN
cord-015021-pol2qm74	3855	25	of	of	IN
cord-015021-pol2qm74	3855	26	sepsis	sepsis	NN
cord-015021-pol2qm74	3855	27	.	.	.
cord-015021-pol2qm74	3856	1	Albert	Albert	NNP
cord-015021-pol2qm74	3856	2	Szent	Szent	NNP
cord-015021-pol2qm74	3856	3	-	-	HYPH
cord-015021-pol2qm74	3856	4	Gy6rgyi	Gy6rgyi	NNP
cord-015021-pol2qm74	3856	5	Medical	Medical	NNP
cord-015021-pol2qm74	3856	6	University	University	NNP
cord-015021-pol2qm74	3856	7	,	,	,
cord-015021-pol2qm74	3856	8	Institute	Institute	NNP
cord-015021-pol2qm74	3856	9	of	of	IN
cord-015021-pol2qm74	3856	10	Microbiology	Microbiology	NNP
cord-015021-pol2qm74	3856	11	,	,	,
cord-015021-pol2qm74	3856	12	Szeged	Szeged	NNP
cord-015021-pol2qm74	3856	13	,	,	,
cord-015021-pol2qm74	3856	14	Hungary	Hungary	NNP
cord-015021-pol2qm74	3856	15	H-6720	h-6720	CD
cord-015021-pol2qm74	3857	1	Ddm	Ddm	NNP
cord-015021-pol2qm74	3857	2	t.	t.	NNP
cord-015021-pol2qm74	3857	3	10	10	CD
cord-015021-pol2qm74	3857	4	.	.	.
cord-015021-pol2qm74	3858	1	E	E	NNP
cord-015021-pol2qm74	3858	2	~	~	NFP
cord-015021-pol2qm74	3858	3	I	i	NN
cord-015021-pol2qm74	3858	4	~	~	NFP
cord-015021-pol2qm74	3858	5	IM~/TII	im~/tii	UH
cord-015021-pol2qm74	3858	6	,	,	,
cord-015021-pol2qm74	3858	7	SEPTIC	SEPTIC	NNP
cord-015021-pol2qm74	3858	8	SH0~	SH0~	NNP
cord-015021-pol2qm74	3858	9	'	'	''
cord-015021-pol2qm74	3858	10	.	.	.
cord-015021-pol2qm74	3859	1	TNF	TNF	NNP
cord-015021-pol2qm74	3859	2	alfa	alfa	NNP
cord-015021-pol2qm74	3859	3	/	/	SYM
cord-015021-pol2qm74	3859	4	PGE	PGE	NNP
cord-015021-pol2qm74	3859	5	,	,	,
cord-015021-pol2qm74	3859	6	and	and	CC
cord-015021-pol2qm74	3859	7	Somatostatln	Somatostatln	NNP
cord-015021-pol2qm74	3859	8	Lands	Lands	NNPS
cord-015021-pol2qm74	3859	9	JI	JI	NNP
cord-015021-pol2qm74	3859	10	.	.	.
cord-015021-pol2qm74	3860	1	,	,	,
cord-015021-pol2qm74	3860	2	Alvarez	Alvarez	NNP
cord-015021-pol2qm74	3860	3	J.	J.	NNP
cord-015021-pol2qm74	3860	4	,	,	,
cord-015021-pol2qm74	3860	5	Gram	Gram	NNP
cord-015021-pol2qm74	3860	6	M.	M.	NNP
cord-015021-pol2qm74	3860	7	,	,	,
cord-015021-pol2qm74	3860	8	Llanos	Llanos	NNP
cord-015021-pol2qm74	3860	9	K.	K.	NNP
cord-015021-pol2qm74	3860	10	,	,	,
cord-015021-pol2qm74	3860	11	Alcalde	Alcalde	NNP
cord-015021-pol2qm74	3860	12	J.	J.	NNP
cord-015021-pol2qm74	3860	13	,	,	,
cord-015021-pol2qm74	3860	14	Sanchez	Sanchez	NNP
cord-015021-pol2qm74	3860	15	JA	JA	NNP
cord-015021-pol2qm74	3860	16	.	.	.
cord-015021-pol2qm74	3861	1	,	,	,
cord-015021-pol2qm74	3861	2	Balibr	Balibr	NNP
cord-015021-pol2qm74	3861	3	~	~	NFP
cord-015021-pol2qm74	3861	4	d	d	NN
cord-015021-pol2qm74	3861	5	JL	JL	NNP
cord-015021-pol2qm74	3861	6	.	.	.
cord-015021-pol2qm74	3862	1	Taurine	taurine	NN
cord-015021-pol2qm74	3862	2	,	,	,
cord-015021-pol2qm74	3862	3	a	a	DT
cord-015021-pol2qm74	3862	4	semi	semi	JJ
cord-015021-pol2qm74	3862	5	-	-	JJ
cord-015021-pol2qm74	3862	6	essential	essential	JJ
cord-015021-pol2qm74	3862	7	sulphur	sulphur	NN
cord-015021-pol2qm74	3862	8	-	-	HYPH
cord-015021-pol2qm74	3862	9	containing	contain	VBG
cord-015021-pol2qm74	3862	10	t:~-amian	t:~-amian	JJ
cord-015021-pol2qm74	3862	11	acid	acid	NN
cord-015021-pol2qm74	3862	12	,	,	,
cord-015021-pol2qm74	3862	13	promotes	promote	VBZ
cord-015021-pol2qm74	3862	14	neutrophil	neutrophil	NN
cord-015021-pol2qm74	3862	15	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	3862	16	activit3	activit3	NN
cord-015021-pol2qm74	3862	17	'	'	''
cord-015021-pol2qm74	3862	18	against	against	IN
cord-015021-pol2qm74	3862	19	yeasts	yeast	NNS
cord-015021-pol2qm74	3862	20	and	and	CC
cord-015021-pol2qm74	3862	21	enhances	enhance	VBZ
cord-015021-pol2qm74	3862	22	intracellular	intracellular	JJ
cord-015021-pol2qm74	3862	23	killing	killing	NN
cord-015021-pol2qm74	3862	24	of	of	IN
cord-015021-pol2qm74	3862	25	E.coli	E.coli	NNS
cord-015021-pol2qm74	3862	26	.	.	.
cord-015021-pol2qm74	3863	1	Paradoxically	paradoxically	RB
cord-015021-pol2qm74	3863	2	it	-PRON-	PRP
cord-015021-pol2qm74	3863	3	protects	protect	VBZ
cord-015021-pol2qm74	3863	4	against	against	IN
cord-015021-pol2qm74	3863	5	hypochlorous	hypochlorous	JJ
cord-015021-pol2qm74	3863	6	acidmediated	acidmediate	VBN
cord-015021-pol2qm74	3863	7	biomembmne	biomembmne	NNP
cord-015021-pol2qm74	3863	8	oxidatio~	oxidatio~	NNP
cord-015021-pol2qm74	3863	9	and	and	CC
cord-015021-pol2qm74	3863	10	abrogates	abrogate	VBZ
cord-015021-pol2qm74	3863	11	the	the	DT
cord-015021-pol2qm74	3863	12	pyrogenic	pyrogenic	JJ
cord-015021-pol2qm74	3863	13	effects	effect	NNS
cord-015021-pol2qm74	3863	14	of	of	IN
cord-015021-pol2qm74	3863	15	intracerebral	intracerebral	JJ
cord-015021-pol2qm74	3863	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3863	17	.	.	.
cord-015021-pol2qm74	3864	1	It	-PRON-	PRP
cord-015021-pol2qm74	3864	2	is	be	VBZ
cord-015021-pol2qm74	3864	3	therefore	therefore	RB
cord-015021-pol2qm74	3864	4	possible	possible	JJ
cord-015021-pol2qm74	3864	5	that	that	IN
cord-015021-pol2qm74	3864	6	taurine	taurine	NN
cord-015021-pol2qm74	3864	7	mediates	mediate	VBZ
cord-015021-pol2qm74	3864	8	some	some	DT
cord-015021-pol2qm74	3864	9	of	of	IN
cord-015021-pol2qm74	3864	10	these	these	DT
cord-015021-pol2qm74	3864	11	effects	effect	NNS
cord-015021-pol2qm74	3864	12	by	by	IN
cord-015021-pol2qm74	3864	13	modulating	modulate	VBG
cord-015021-pol2qm74	3864	14	the	the	DT
cord-015021-pol2qm74	3864	15	cytokine	cytokine	NN
cord-015021-pol2qm74	3864	16	cascade	cascade	NN
cord-015021-pol2qm74	3864	17	.	.	.
cord-015021-pol2qm74	3865	1	Aim	aim	VB
cord-015021-pol2qm74	3865	2	To	to	TO
cord-015021-pol2qm74	3865	3	assess	assess	VB
cord-015021-pol2qm74	3865	4	the	the	DT
cord-015021-pol2qm74	3865	5	cytekine	cytekine	NN
cord-015021-pol2qm74	3865	6	responses	response	NNS
cord-015021-pol2qm74	3865	7	in	in	IN
cord-015021-pol2qm74	3865	8	a	a	DT
cord-015021-pol2qm74	3865	9	rat	rat	NN
cord-015021-pol2qm74	3865	10	model	model	NN
cord-015021-pol2qm74	3865	11	of	of	IN
cord-015021-pol2qm74	3865	12	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	3865	13	sepsis	sepsis	NN
cord-015021-pol2qm74	3865	14	,	,	,
cord-015021-pol2qm74	3865	15	pretreated	pretreate	VBN
cord-015021-pol2qm74	3865	16	with	with	IN
cord-015021-pol2qm74	3865	17	supplenmntary	supplenmntary	JJ
cord-015021-pol2qm74	3865	18	taurine	taurine	NN
cord-015021-pol2qm74	3865	19	,	,	,
cord-015021-pol2qm74	3865	20	by	by	IN
cord-015021-pol2qm74	3865	21	measuring	measure	VBG
cord-015021-pol2qm74	3865	22	TNF	TNF	NNP
cord-015021-pol2qm74	3865	23	and	and	CC
cord-015021-pol2qm74	3865	24	IL-6	IL-6	NNP
cord-015021-pol2qm74	3865	25	concentrations	concentration	NNS
cord-015021-pol2qm74	3865	26	.	.	.
cord-015021-pol2qm74	3866	1	Methodology	Methodology	NNP
cord-015021-pol2qm74	3866	2	Female	female	JJ
cord-015021-pol2qm74	3866	3	Wistar	Wistar	NNP
cord-015021-pol2qm74	3866	4	rats	rat	NNS
cord-015021-pol2qm74	3866	5	(	(	-LRB-
cord-015021-pol2qm74	3866	6	wt	wt	NN
cord-015021-pol2qm74	3866	7	160	160	CD
cord-015021-pol2qm74	3866	8	-	-	HYPH
cord-015021-pol2qm74	3866	9	200	200	CD
cord-015021-pol2qm74	3866	10	g	g	NN
cord-015021-pol2qm74	3866	11	)	)	-RRB-
cord-015021-pol2qm74	3866	12	(	(	-LRB-
cord-015021-pol2qm74	3866	13	n-6	n-6	NN
cord-015021-pol2qm74	3866	14	per	per	IN
cord-015021-pol2qm74	3866	15	group	group	NN
cord-015021-pol2qm74	3866	16	)	)	-RRB-
cord-015021-pol2qm74	3866	17	were	be	VBD
cord-015021-pol2qm74	3866	18	prefed	prefed	NNP
cord-015021-pol2qm74	3866	19	with	with	IN
cord-015021-pol2qm74	3866	20	2	2	CD
cord-015021-pol2qm74	3866	21	%	%	NN
cord-015021-pol2qm74	3866	22	tanrine	tanrine	NN
cord-015021-pol2qm74	3866	23	,	,	,
cord-015021-pol2qm74	3866	24	3.33	3.33	CD
cord-015021-pol2qm74	3866	25	%	%	NN
cord-015021-pol2qm74	3866	26	glyciuc	glyciuc	NN
cord-015021-pol2qm74	3866	27	(	(	-LRB-
cord-015021-pol2qm74	3866	28	in	in	IN
cord-015021-pol2qm74	3866	29	tap	tap	NN
cord-015021-pol2qm74	3866	30	water	water	NN
cord-015021-pol2qm74	3866	31	)	)	-RRB-
cord-015021-pol2qm74	3866	32	or	or	CC
cord-015021-pol2qm74	3866	33	tap	tap	NN
cord-015021-pol2qm74	3866	34	water	water	NN
cord-015021-pol2qm74	3866	35	(	(	-LRB-
cord-015021-pol2qm74	3866	36	TW	TW	NNP
cord-015021-pol2qm74	3866	37	)	)	-RRB-
cord-015021-pol2qm74	3866	38	for	for	IN
cord-015021-pol2qm74	3866	39	15	15	CD
cord-015021-pol2qm74	3866	40	days	day	NNS
cord-015021-pol2qm74	3866	41	prior	prior	RB
cord-015021-pol2qm74	3866	42	to	to	IN
cord-015021-pol2qm74	3866	43	caecal	caecal	JJ
cord-015021-pol2qm74	3866	44	ligation	ligation	NN
cord-015021-pol2qm74	3866	45	aud	aud	NN
cord-015021-pol2qm74	3866	46	puncture	puncture	NN
cord-015021-pol2qm74	3866	47	(	(	-LRB-
cord-015021-pol2qm74	3866	48	CLP	CLP	NNP
cord-015021-pol2qm74	3866	49	)	)	-RRB-
cord-015021-pol2qm74	3866	50	.	.	.
cord-015021-pol2qm74	3867	1	Normothermia	Normothermia	NNP
cord-015021-pol2qm74	3867	2	was	be	VBD
cord-015021-pol2qm74	3867	3	maintained	maintain	VBN
cord-015021-pol2qm74	3867	4	intraoperatively	intraoperatively	NN
cord-015021-pol2qm74	3867	5	and	and	CC
cord-015021-pol2qm74	3867	6	the	the	DT
cord-015021-pol2qm74	3867	7	animals	animal	NNS
cord-015021-pol2qm74	3867	8	received	receive	VBD
cord-015021-pol2qm74	3867	9	0.9	0.9	CD
cord-015021-pol2qm74	3867	10	%	%	NN
cord-015021-pol2qm74	3867	11	saline	saline	NN
cord-015021-pol2qm74	3867	12	subcutaneously	subcutaneously	RB
cord-015021-pol2qm74	3867	13	(	(	-LRB-
cord-015021-pol2qm74	3867	14	3	3	CD
cord-015021-pol2qm74	3867	15	mls/100	mls/100	NNS
cord-015021-pol2qm74	3867	16	g	g	NN
cord-015021-pol2qm74	3867	17	)	)	-RRB-
cord-015021-pol2qm74	3867	18	post	post	NN
cord-015021-pol2qm74	3867	19	-	-	NN
cord-015021-pol2qm74	3867	20	procedure	procedure	NN
cord-015021-pol2qm74	3867	21	.	.	.
cord-015021-pol2qm74	3868	1	Animals	animal	NNS
cord-015021-pol2qm74	3868	2	were	be	VBD
cord-015021-pol2qm74	3868	3	venosected	venosecte	VBN
cord-015021-pol2qm74	3868	4	by	by	IN
cord-015021-pol2qm74	3868	5	direct	direct	JJ
cord-015021-pol2qm74	3868	6	cardiac	cardiac	JJ
cord-015021-pol2qm74	3868	7	puncture	puncture	NN
cord-015021-pol2qm74	3868	8	at	at	IN
cord-015021-pol2qm74	3868	9	6	6	CD
cord-015021-pol2qm74	3868	10	or	or	CC
cord-015021-pol2qm74	3868	11	18	18	CD
cord-015021-pol2qm74	3868	12	hours	hour	NNS
cord-015021-pol2qm74	3868	13	post	post	NN
cord-015021-pol2qm74	3868	14	-	-	NN
cord-015021-pol2qm74	3868	15	operation	operation	NN
cord-015021-pol2qm74	3868	16	and	and	CC
cord-015021-pol2qm74	3868	17	the	the	DT
cord-015021-pol2qm74	3868	18	blood	blood	NN
cord-015021-pol2qm74	3868	19	placed	place	VBN
cord-015021-pol2qm74	3868	20	in	in	IN
cord-015021-pol2qm74	3868	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	3868	22	-	-	HYPH
cord-015021-pol2qm74	3868	23	free	free	JJ
cord-015021-pol2qm74	3868	24	tubes	tube	NNS
cord-015021-pol2qm74	3868	25	.	.	.
cord-015021-pol2qm74	3869	1	Centrifilgation	centrifilgation	NN
cord-015021-pol2qm74	3869	2	and	and	CC
cord-015021-pol2qm74	3869	3	storage	storage	NN
cord-015021-pol2qm74	3869	4	of	of	IN
cord-015021-pol2qm74	3869	5	plasma	plasma	NN
cord-015021-pol2qm74	3869	6	at	at	IN
cord-015021-pol2qm74	3869	7	-70	-70	NN
cord-015021-pol2qm74	3869	8	°	°	NN
cord-015021-pol2qm74	3870	1	C	C	NNP
cord-015021-pol2qm74	3870	2	was	be	VBD
cord-015021-pol2qm74	3870	3	completed	complete	VBN
cord-015021-pol2qm74	3870	4	within	within	IN
cord-015021-pol2qm74	3870	5	2	2	CD
cord-015021-pol2qm74	3870	6	hours	hour	NNS
cord-015021-pol2qm74	3870	7	.	.	.
cord-015021-pol2qm74	3871	1	TNF	TNF	NNP
cord-015021-pol2qm74	3871	2	and	and	CC
cord-015021-pol2qm74	3871	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	3871	4	were	be	VBD
cord-015021-pol2qm74	3871	5	measured	measure	VBN
cord-015021-pol2qm74	3871	6	using	use	VBG
cord-015021-pol2qm74	3871	7	WEHI	WEHI	NNP
cord-015021-pol2qm74	3871	8	and	and	CC
cord-015021-pol2qm74	3871	9	B9	B9	NNP
cord-015021-pol2qm74	3871	10	bioassays	bioassays	NNP
cord-015021-pol2qm74	3871	11	respectively	respectively	RB
cord-015021-pol2qm74	3871	12	.	.	.
cord-015021-pol2qm74	3872	1	Results	result	NNS
cord-015021-pol2qm74	3872	2	(	(	-LRB-
cord-015021-pol2qm74	3872	3	Means	mean	VBZ
cord-015021-pol2qm74	3872	4	±	±	NNP
cord-015021-pol2qm74	3872	5	SEM	SEM	NNP
cord-015021-pol2qm74	3872	6	)	)	-RRB-
cord-015021-pol2qm74	3873	1	Bioactivc	Bioactivc	NNP
cord-015021-pol2qm74	3873	2	TNF	TNF	NNP
cord-015021-pol2qm74	3873	3	concentrations	concentration	NNS
cord-015021-pol2qm74	3873	4	were	be	VBD
cord-015021-pol2qm74	3873	5	not	not	RB
cord-015021-pol2qm74	3873	6	significantly	significantly	RB
cord-015021-pol2qm74	3873	7	different	different	JJ
cord-015021-pol2qm74	3873	8	between	between	IN
cord-015021-pol2qm74	3873	9	CLP	CLP	NNP
cord-015021-pol2qm74	3873	10	or	or	CC
cord-015021-pol2qm74	3873	11	sham	sham	NN
cord-015021-pol2qm74	3873	12	groups	group	NNS
cord-015021-pol2qm74	3873	13	.	.	.
cord-015021-pol2qm74	3874	1	However	however	RB
cord-015021-pol2qm74	3874	2	plasma	plasma	NN
cord-015021-pol2qm74	3874	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	3874	4	estimation	estimation	NN
cord-015021-pol2qm74	3874	5	revealed	reveal	VBD
cord-015021-pol2qm74	3874	6	a	a	DT
cord-015021-pol2qm74	3874	7	statistically	statistically	RB
cord-015021-pol2qm74	3874	8	significant	significant	JJ
cord-015021-pol2qm74	3874	9	reduction	reduction	NN
cord-015021-pol2qm74	3874	10	at	at	IN
cord-015021-pol2qm74	3874	11	6	6	CD
cord-015021-pol2qm74	3874	12	hours	hour	NNS
cord-015021-pol2qm74	3874	13	in	in	IN
cord-015021-pol2qm74	3874	14	tanrine	tanrine	NN
cord-015021-pol2qm74	3874	15	-	-	HYPH
cord-015021-pol2qm74	3874	16	treated	treat	VBN
cord-015021-pol2qm74	3874	17	animals	animal	NNS
cord-015021-pol2qm74	3874	18	compared	compare	VBN
cord-015021-pol2qm74	3874	19	to	to	IN
cord-015021-pol2qm74	3874	20	glycino	glycino	NN
cord-015021-pol2qm74	3874	21	and	and	CC
cord-015021-pol2qm74	3874	22	TW	TW	NNP
cord-015021-pol2qm74	3874	23	controls	control	NNS
cord-015021-pol2qm74	3875	1	(	(	-LRB-
cord-015021-pol2qm74	3875	2	Objective	objective	NN
cord-015021-pol2qm74	3875	3	:	:	:
cord-015021-pol2qm74	3876	1	To	to	TO
cord-015021-pol2qm74	3876	2	evaluate	evaluate	VB
cord-015021-pol2qm74	3876	3	the	the	DT
cord-015021-pol2qm74	3876	4	effects	effect	NNS
cord-015021-pol2qm74	3876	5	of	of	IN
cord-015021-pol2qm74	3876	6	allogeneic	allogeneic	NN
cord-015021-pol2qm74	3876	7	blood	blood	NN
cord-015021-pol2qm74	3876	8	transfusion	transfusion	NN
cord-015021-pol2qm74	3876	9	,	,	,
cord-015021-pol2qm74	3876	10	thermal	thermal	JJ
cord-015021-pol2qm74	3876	11	injury	injury	NN
cord-015021-pol2qm74	3876	12	and	and	CC
cord-015021-pol2qm74	3876	13	bacterial	bacterial	JJ
cord-015021-pol2qm74	3876	14	garage	garage	NN
cord-015021-pol2qm74	3876	15	on	on	IN
cord-015021-pol2qm74	3876	16	interteukin	interteukin	NNP
cord-015021-pol2qm74	3876	17	4	4	CD
cord-015021-pol2qm74	3876	18	(	(	-LRB-
cord-015021-pol2qm74	3876	19	IL-4	IL-4	NNP
cord-015021-pol2qm74	3876	20	)	)	-RRB-
cord-015021-pol2qm74	3876	21	,	,	,
cord-015021-pol2qm74	3876	22	tumor	tumor	NN
cord-015021-pol2qm74	3876	23	necrosis	necrosis	NN
cord-015021-pol2qm74	3876	24	factor	factor	NN
cord-015021-pol2qm74	3876	25	alpha	alpha	NN
cord-015021-pol2qm74	3876	26	(	(	-LRB-
cord-015021-pol2qm74	3876	27	TNF	TNF	NNP
cord-015021-pol2qm74	3876	28	)	)	-RRB-
cord-015021-pol2qm74	3876	29	production	production	NN
cord-015021-pol2qm74	3876	30	and	and	CC
cord-015021-pol2qm74	3876	31	host	host	NN
cord-015021-pol2qm74	3876	32	mortality	mortality	NN
cord-015021-pol2qm74	3876	33	and	and	CC
cord-015021-pol2qm74	3876	34	to	to	TO
cord-015021-pol2qm74	3876	35	study	study	VB
cord-015021-pol2qm74	3876	36	if	if	IN
cord-015021-pol2qm74	3876	37	the	the	DT
cord-015021-pol2qm74	3876	38	administration	administration	NN
cord-015021-pol2qm74	3876	39	of	of	IN
cord-015021-pol2qm74	3876	40	thymopentth	thymopentth	NNP
cord-015021-pol2qm74	3876	41	(	(	-LRB-
cord-015021-pol2qm74	3876	42	THY	THY	NNP
cord-015021-pol2qm74	3876	43	)	)	-RRB-
cord-015021-pol2qm74	3876	44	could	could	MD
cord-015021-pol2qm74	3876	45	affect	affect	VB
cord-015021-pol2qm74	3876	46	these	these	DT
cord-015021-pol2qm74	3876	47	events	event	NNS
cord-015021-pol2qm74	3876	48	.	.	.
cord-015021-pol2qm74	3877	1	Materials	material	NNS
cord-015021-pol2qm74	3877	2	and	and	CC
cord-015021-pol2qm74	3877	3	Methods	method	NNS
cord-015021-pol2qm74	3877	4	:	:	:
cord-015021-pol2qm74	3877	5	BALB	BALB	NNP
cord-015021-pol2qm74	3877	6	/	/	SYM
cord-015021-pol2qm74	3877	7	c	c	NN
cord-015021-pol2qm74	3877	8	mice	mouse	NNS
cord-015021-pol2qm74	3877	9	were	be	VBD
cord-015021-pol2qm74	3877	10	transfused	transfuse	VBN
cord-015021-pol2qm74	3877	11	with	with	IN
cord-015021-pol2qm74	3877	12	allogeneic	allogeneic	NN
cord-015021-pol2qm74	3877	13	blood	blood	NN
cord-015021-pol2qm74	3877	14	(	(	-LRB-
cord-015021-pol2qm74	3877	15	from	from	IN
cord-015021-pol2qm74	3877	16	C3H	C3H	NNP
cord-015021-pol2qm74	3877	17	/	/	SYM
cord-015021-pol2qm74	3877	18	HeJ	HeJ	NNP
cord-015021-pol2qm74	3877	19	mice	mouse	NNS
cord-015021-pol2qm74	3877	20	)	)	-RRB-
cord-015021-pol2qm74	3877	21	and	and	CC
cord-015021-pol2qm74	3877	22	treated	treat	VBN
cord-015021-pol2qm74	3877	23	daily	daily	RB
cord-015021-pol2qm74	3877	24	with	with	IN
cord-015021-pol2qm74	3877	25	THY	THY	NNP
cord-015021-pol2qm74	3878	1	(	(	-LRB-
cord-015021-pol2qm74	3878	2	I	-PRON-	PRP
cord-015021-pol2qm74	3878	3	mg	mg	NNP
cord-015021-pol2qm74	3878	4	/	/	SYM
cord-015021-pol2qm74	3878	5	kg)(T+THY	kg)(T+THY	NNP
cord-015021-pol2qm74	3878	6	)	)	-RRB-
cord-015021-pol2qm74	3878	7	.	.	.
cord-015021-pol2qm74	3879	1	Control	control	NN
cord-015021-pol2qm74	3879	2	animals	animal	NNS
cord-015021-pol2qm74	3879	3	were	be	VBD
cord-015021-pol2qm74	3879	4	transfused	transfuse	VBN
cord-015021-pol2qm74	3879	5	but	but	CC
cord-015021-pol2qm74	3879	6	not	not	RB
cord-015021-pol2qm74	3879	7	treated	treat	VBN
cord-015021-pol2qm74	3879	8	(	(	-LRB-
cord-015021-pol2qm74	3879	9	T	T	NNP
cord-015021-pol2qm74	3879	10	)	)	-RRB-
cord-015021-pol2qm74	3879	11	.	.	.
cord-015021-pol2qm74	3880	1	After	after	IN
cord-015021-pol2qm74	3880	2	5	5	CD
cord-015021-pol2qm74	3880	3	days	day	NNS
cord-015021-pol2qm74	3880	4	systemic	systemic	JJ
cord-015021-pol2qm74	3880	5	blood	blood	NN
cord-015021-pol2qm74	3880	6	was	be	VBD
cord-015021-pol2qm74	3880	7	harvested	harvest	VBN
cord-015021-pol2qm74	3880	8	to	to	TO
cord-015021-pol2qm74	3880	9	determine	determine	VB
cord-015021-pol2qm74	3880	10	the	the	DT
cord-015021-pol2qm74	3880	11	circulating	circulate	VBG
cord-015021-pol2qm74	3880	12	levels	level	NNS
cord-015021-pol2qm74	3880	13	of	of	IN
cord-015021-pol2qm74	3880	14	IL4	IL4	NNP
cord-015021-pol2qm74	3880	15	and	and	CC
cord-015021-pol2qm74	3880	16	TNF	TNF	NNP
cord-015021-pol2qm74	3880	17	.	.	.
cord-015021-pol2qm74	3881	1	A	a	DT
cord-015021-pol2qm74	3881	2	second	second	JJ
cord-015021-pol2qm74	3881	3	group	group	NN
cord-015021-pol2qm74	3881	4	was	be	VBD
cord-015021-pol2qm74	3881	5	treated	treat	VBN
cord-015021-pol2qm74	3881	6	with	with	IN
cord-015021-pol2qm74	3881	7	THY	THY	NNP
cord-015021-pol2qm74	3881	8	for	for	IN
cord-015021-pol2qm74	3881	9	5	5	CD
cord-015021-pol2qm74	3881	10	days	day	NNS
cord-015021-pol2qm74	3881	11	and	and	CC
cord-015021-pol2qm74	3881	12	then	then	RB
cord-015021-pol2qm74	3881	13	received	receive	VBD
cord-015021-pol2qm74	3881	14	a	a	DT
cord-015021-pol2qm74	3881	15	gavage	gavage	NN
cord-015021-pol2qm74	3881	16	wide	wide	JJ
cord-015021-pol2qm74	3881	17	lxl09	lxl09	''
cord-015021-pol2qm74	3881	18	Escherichia	escherichia	NN
cord-015021-pol2qm74	3881	19	coli	coli	NNS
cord-015021-pol2qm74	3881	20	and	and	CC
cord-015021-pol2qm74	3881	21	a	a	DT
cord-015021-pol2qm74	3881	22	20	20	CD
cord-015021-pol2qm74	3881	23	%	%	NN
cord-015021-pol2qm74	3881	24	burn	burn	NN
cord-015021-pol2qm74	3881	25	injury	injury	NN
cord-015021-pol2qm74	3881	26	(	(	-LRB-
cord-015021-pol2qm74	3881	27	BG+THY	BG+THY	NNP
cord-015021-pol2qm74	3881	28	)	)	-RRB-
cord-015021-pol2qm74	3881	29	.	.	.
cord-015021-pol2qm74	3882	1	One	one	CD
cord-015021-pol2qm74	3882	2	hour	hour	NN
cord-015021-pol2qm74	3882	3	post	post	NN
cord-015021-pol2qm74	3882	4	-	-	JJ
cord-015021-pol2qm74	3882	5	bum	bum	JJ
cord-015021-pol2qm74	3882	6	,	,	,
cord-015021-pol2qm74	3882	7	blood	blood	NN
cord-015021-pol2qm74	3882	8	was	be	VBD
cord-015021-pol2qm74	3882	9	collected	collect	VBN
cord-015021-pol2qm74	3882	10	to	to	TO
cord-015021-pol2qm74	3882	11	measure	measure	VB
cord-015021-pol2qm74	3882	12	cytokins	cytokin	NNS
cord-015021-pol2qm74	3882	13	.	.	.
cord-015021-pol2qm74	3883	1	Control	control	NN
cord-015021-pol2qm74	3883	2	animals	animal	NNS
cord-015021-pol2qm74	3883	3	received	receive	VBD
cord-015021-pol2qm74	3883	4	the	the	DT
cord-015021-pol2qm74	3883	5	same	same	JJ
cord-015021-pol2qm74	3883	6	treatment	treatment	NN
cord-015021-pol2qm74	3883	7	but	but	CC
cord-015021-pol2qm74	3883	8	THY	THY	NNP
cord-015021-pol2qm74	3883	9	(	(	-LRB-
cord-015021-pol2qm74	3883	10	BG	BG	NNP
cord-015021-pol2qm74	3883	11	)	)	-RRB-
cord-015021-pol2qm74	3883	12	.	.	.
cord-015021-pol2qm74	3884	1	A	a	DT
cord-015021-pol2qm74	3884	2	Third	third	JJ
cord-015021-pol2qm74	3884	3	group	group	NN
cord-015021-pol2qm74	3884	4	was	be	VBD
cord-015021-pol2qm74	3884	5	transfused	transfuse	VBN
cord-015021-pol2qm74	3884	6	,	,	,
cord-015021-pol2qm74	3884	7	treated	treat	VBN
cord-015021-pol2qm74	3884	8	with	with	IN
cord-015021-pol2qm74	3884	9	THY	THY	NNP
cord-015021-pol2qm74	3884	10	for	for	IN
cord-015021-pol2qm74	3884	11	5	5	CD
cord-015021-pol2qm74	3884	12	days	day	NNS
cord-015021-pol2qm74	3884	13	and	and	CC
cord-015021-pol2qm74	3884	14	then	then	RB
cord-015021-pol2qm74	3884	15	received	receive	VBD
cord-015021-pol2qm74	3884	16	gavage	gavage	NN
cord-015021-pol2qm74	3884	17	and	and	CC
cord-015021-pol2qm74	3884	18	burn	burn	VB
cord-015021-pol2qm74	3884	19	(	(	-LRB-
cord-015021-pol2qm74	3884	20	TBG+THY	TBG+THY	NNP
cord-015021-pol2qm74	3884	21	)	)	-RRB-
cord-015021-pol2qm74	3884	22	.	.	.
cord-015021-pol2qm74	3885	1	One	one	CD
cord-015021-pol2qm74	3885	2	hour	hour	NN
cord-015021-pol2qm74	3885	3	post	post	NN
cord-015021-pol2qm74	3885	4	-	-	JJ
cord-015021-pol2qm74	3885	5	burn	burn	JJ
cord-015021-pol2qm74	3885	6	,	,	,
cord-015021-pol2qm74	3885	7	blood	blood	NN
cord-015021-pol2qm74	3885	8	was	be	VBD
cord-015021-pol2qm74	3885	9	collected	collect	VBN
cord-015021-pol2qm74	3885	10	to	to	TO
cord-015021-pol2qm74	3885	11	measure	measure	VB
cord-015021-pol2qm74	3885	12	cytokins	cytokin	NNS
cord-015021-pol2qm74	3885	13	.	.	.
cord-015021-pol2qm74	3886	1	Control	control	NN
cord-015021-pol2qm74	3886	2	animals	animal	NNS
cord-015021-pol2qm74	3886	3	received	receive	VBD
cord-015021-pol2qm74	3886	4	the	the	DT
cord-015021-pol2qm74	3886	5	same	same	JJ
cord-015021-pol2qm74	3886	6	treatment	treatment	NN
cord-015021-pol2qm74	3886	7	but	but	CC
cord-015021-pol2qm74	3886	8	THY	THY	NNP
cord-015021-pol2qm74	3886	9	(	(	-LRB-
cord-015021-pol2qm74	3886	10	TBG	TBG	NNP
cord-015021-pol2qm74	3886	11	)	)	-RRB-
cord-015021-pol2qm74	3886	12	.	.	.
cord-015021-pol2qm74	3887	1	All	all	DT
cord-015021-pol2qm74	3887	2	treated	treat	VBN
cord-015021-pol2qm74	3887	3	and	and	CC
cord-015021-pol2qm74	3887	4	control	control	NN
cord-015021-pol2qm74	3887	5	groups	group	NNS
cord-015021-pol2qm74	3887	6	had	have	VBD
cord-015021-pol2qm74	3887	7	8	8	CD
cord-015021-pol2qm74	3887	8	mice	mouse	NNS
cord-015021-pol2qm74	3887	9	/	/	SYM
cord-015021-pol2qm74	3887	10	group	group	NN
cord-015021-pol2qm74	3887	11	.	.	.
cord-015021-pol2qm74	3888	1	In	in	IN
cord-015021-pol2qm74	3888	2	separate	separate	JJ
cord-015021-pol2qm74	3888	3	groups	group	NNS
cord-015021-pol2qm74	3888	4	(	(	-LRB-
cord-015021-pol2qm74	3888	5	n=20	n=20	NNP
cord-015021-pol2qm74	3888	6	/	/	SYM
cord-015021-pol2qm74	3888	7	group	group	NN
cord-015021-pol2qm74	3888	8	)	)	-RRB-
cord-015021-pol2qm74	3888	9	,	,	,
cord-015021-pol2qm74	3888	10	receiving	receive	VBG
cord-015021-pol2qm74	3888	11	the	the	DT
cord-015021-pol2qm74	3888	12	same	same	JJ
cord-015021-pol2qm74	3888	13	treatments	treatment	NNS
cord-015021-pol2qm74	3888	14	,	,	,
cord-015021-pol2qm74	3888	15	mortality	mortality	NN
cord-015021-pol2qm74	3888	16	was	be	VBD
cord-015021-pol2qm74	3888	17	observed	observe	VBN
cord-015021-pol2qm74	3888	18	for	for	IN
cord-015021-pol2qm74	3888	19	10	10	CD
cord-015021-pol2qm74	3888	20	days	day	NNS
cord-015021-pol2qm74	3888	21	post	post	NN
cord-015021-pol2qm74	3888	22	-	-	JJ
cord-015021-pol2qm74	3888	23	burn	burn	JJ
cord-015021-pol2qm74	3888	24	or	or	CC
cord-015021-pol2qm74	3888	25	transfusion	transfusion	NN
cord-015021-pol2qm74	3888	26	.	.	.
cord-015021-pol2qm74	3889	1	The	the	DT
cord-015021-pol2qm74	3889	2	production	production	NN
cord-015021-pol2qm74	3889	3	and	and	CC
cord-015021-pol2qm74	3889	4	release	release	NN
cord-015021-pol2qm74	3889	5	of	of	IN
cord-015021-pol2qm74	3889	6	oxygen	oxygen	NN
cord-015021-pol2qm74	3889	7	radicals	radical	NNS
cord-015021-pol2qm74	3889	8	by	by	IN
cord-015021-pol2qm74	3889	9	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	3889	10	leukomytee	leukomytee	NNP
cord-015021-pol2qm74	3889	11	is	be	VBZ
cord-015021-pol2qm74	3889	12	one	one	CD
cord-015021-pol2qm74	3889	13	of	of	IN
cord-015021-pol2qm74	3889	14	the	the	DT
cord-015021-pol2qm74	3889	15	most	most	RBS
cord-015021-pol2qm74	3889	16	relevant	relevant	JJ
cord-015021-pol2qm74	3889	17	and	and	CC
cord-015021-pol2qm74	3889	18	important	important	JJ
cord-015021-pol2qm74	3889	19	functions	function	NNS
cord-015021-pol2qm74	3889	20	of	of	IN
cord-015021-pol2qm74	3889	21	these	these	DT
cord-015021-pol2qm74	3889	22	substances	substance	NNS
cord-015021-pol2qm74	3889	23	in	in	IN
cord-015021-pol2qm74	3889	24	biology	biology	NN
cord-015021-pol2qm74	3889	25	.	.	.
cord-015021-pol2qm74	3890	1	When	when	WRB
cord-015021-pol2qm74	3890	2	neutrophilic	neutrophilic	JJ
cord-015021-pol2qm74	3890	3	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	3890	4	or	or	CC
cord-015021-pol2qm74	3890	5	certain	certain	JJ
cord-015021-pol2qm74	3890	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	3890	7	phagocytize	phagocytize	NN
cord-015021-pol2qm74	3891	1	they	-PRON-	PRP
cord-015021-pol2qm74	3891	2	produce	produce	VBP
cord-015021-pol2qm74	3891	3	super	super	JJ
cord-015021-pol2qm74	3891	4	oxide	oxide	NN
cord-015021-pol2qm74	3891	5	and	and	CC
cord-015021-pol2qm74	3891	6	hydrogen	hydrogen	NN
cord-015021-pol2qm74	3891	7	peroxide	peroxide	NN
cord-015021-pol2qm74	3891	8	and	and	CC
cord-015021-pol2qm74	3891	9	form	form	VB
cord-015021-pol2qm74	3891	10	secondary	secondary	JJ
cord-015021-pol2qm74	3891	11	products	product	NNS
cord-015021-pol2qm74	3891	12	of	of	IN
cord-015021-pol2qm74	3891	13	these	these	DT
cord-015021-pol2qm74	3891	14	activated	activate	VBN
cord-015021-pol2qm74	3891	15	species	specie	NNS
cord-015021-pol2qm74	3891	16	.	.	.
cord-015021-pol2qm74	3892	1	All	all	DT
cord-015021-pol2qm74	3892	2	of	of	IN
cord-015021-pol2qm74	3892	3	these	these	DT
cord-015021-pol2qm74	3892	4	substances	substance	NNS
cord-015021-pol2qm74	3892	5	are	be	VBP
cord-015021-pol2qm74	3892	6	released	release	VBN
cord-015021-pol2qm74	3892	7	in	in	IN
cord-015021-pol2qm74	3892	8	to	to	IN
cord-015021-pol2qm74	3892	9	the	the	DT
cord-015021-pol2qm74	3892	10	phagosome	phagosome	NN
cord-015021-pol2qm74	3892	11	.	.	.
cord-015021-pol2qm74	3893	1	It	-PRON-	PRP
cord-015021-pol2qm74	3893	2	has	have	VBZ
cord-015021-pol2qm74	3893	3	been	be	VBN
cord-015021-pol2qm74	3893	4	appreciated	appreciate	VBN
cord-015021-pol2qm74	3893	5	since	since	IN
cord-015021-pol2qm74	3893	6	1977	1977	CD
cord-015021-pol2qm74	3893	7	that	that	IN
cord-015021-pol2qm74	3893	8	the	the	DT
cord-015021-pol2qm74	3893	9	amount	amount	NN
cord-015021-pol2qm74	3893	10	of	of	IN
cord-015021-pol2qm74	3893	11	oxygen	oxygen	NN
cord-015021-pol2qm74	3893	12	consumed	consume	VBN
cord-015021-pol2qm74	3893	13	by	by	IN
cord-015021-pol2qm74	3893	14	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	3893	15	in	in	IN
cord-015021-pol2qm74	3893	16	producing	produce	VBG
cord-015021-pol2qm74	3893	17	free	free	JJ
cord-015021-pol2qm74	3893	18	radicals	radical	NNS
cord-015021-pol2qm74	3893	19	is	be	VBZ
cord-015021-pol2qm74	3893	20	prodigious	prodigious	JJ
cord-015021-pol2qm74	3893	21	.	.	.
cord-015021-pol2qm74	3894	1	What	what	WP
cord-015021-pol2qm74	3894	2	has	have	VBZ
cord-015021-pol2qm74	3894	3	not	not	RB
cord-015021-pol2qm74	3894	4	been	be	VBN
cord-015021-pol2qm74	3894	5	totally	totally	RB
cord-015021-pol2qm74	3894	6	appreciated	appreciate	VBN
cord-015021-pol2qm74	3894	7	is	be	VBZ
cord-015021-pol2qm74	3894	8	the	the	DT
cord-015021-pol2qm74	3894	9	significant	significant	JJ
cord-015021-pol2qm74	3894	10	contribution	contribution	NN
cord-015021-pol2qm74	3894	11	this	this	DT
cord-015021-pol2qm74	3894	12	02	02	CD
cord-015021-pol2qm74	3894	13	consumption	consumption	NN
cord-015021-pol2qm74	3894	14	contributes	contribute	VBZ
cord-015021-pol2qm74	3894	15	to	to	IN
cord-015021-pol2qm74	3894	16	total	total	JJ
cord-015021-pol2qm74	3894	17	body	body	NN
cord-015021-pol2qm74	3894	18	oxygen	oxygen	NN
cord-015021-pol2qm74	3894	19	consumption	consumption	NN
cord-015021-pol2qm74	3894	20	.	.	.
cord-015021-pol2qm74	3895	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	3895	2	understanding	understanding	NN
cord-015021-pol2qm74	3895	3	of	of	IN
cord-015021-pol2qm74	3895	4	increased	increase	VBN
cord-015021-pol2qm74	3895	5	oxygen	oxygen	NN
cord-015021-pol2qm74	3895	6	consumption	consumption	NN
cord-015021-pol2qm74	3895	7	following	follow	VBG
cord-015021-pol2qm74	3895	8	sepsis	sepsis	NN
cord-015021-pol2qm74	3895	9	is	be	VBZ
cord-015021-pol2qm74	3895	10	compounded	compound	VBN
cord-015021-pol2qm74	3895	11	by	by	IN
cord-015021-pol2qm74	3895	12	a	a	DT
cord-015021-pol2qm74	3895	13	paradox	paradox	NN
cord-015021-pol2qm74	3895	14	of	of	IN
cord-015021-pol2qm74	3895	15	increased	increase	VBN
cord-015021-pol2qm74	3895	16	cardiac	cardiac	JJ
cord-015021-pol2qm74	3895	17	index	index	NN
cord-015021-pol2qm74	3895	18	and	and	CC
cord-015021-pol2qm74	3895	19	a	a	DT
cord-015021-pol2qm74	3895	20	narrow	narrow	JJ
cord-015021-pol2qm74	3895	21	AV02	av02	NN
cord-015021-pol2qm74	3895	22	difference	difference	NN
cord-015021-pol2qm74	3895	23	.	.	.
cord-015021-pol2qm74	3896	1	It	-PRON-	PRP
cord-015021-pol2qm74	3896	2	was	be	VBD
cord-015021-pol2qm74	3896	3	McLean	McLean	NNP
cord-015021-pol2qm74	3896	4	in	in	IN
cord-015021-pol2qm74	3896	5	a	a	DT
cord-015021-pol2qm74	3896	6	study	study	NN
cord-015021-pol2qm74	3896	7	reported	report	VBN
cord-015021-pol2qm74	3896	8	in	in	IN
cord-015021-pol2qm74	3896	9	1967	1967	CD
cord-015021-pol2qm74	3896	10	that	that	WDT
cord-015021-pol2qm74	3896	11	showed	show	VBD
cord-015021-pol2qm74	3896	12	an	an	DT
cord-015021-pol2qm74	3896	13	increase	increase	NN
cord-015021-pol2qm74	3896	14	in	in	IN
cord-015021-pol2qm74	3896	15	cardiac	cardiac	JJ
cord-015021-pol2qm74	3896	16	index	index	NN
cord-015021-pol2qm74	3896	17	and	and	CC
cord-015021-pol2qm74	3896	18	a	a	DT
cord-015021-pol2qm74	3896	19	narrowing	narrowing	NN
cord-015021-pol2qm74	3896	20	of	of	IN
cord-015021-pol2qm74	3896	21	the	the	DT
cord-015021-pol2qm74	3896	22	AVO	AVO	NNP
cord-015021-pol2qm74	3896	23	z	z	NN
cord-015021-pol2qm74	3896	24	difference	difference	NN
cord-015021-pol2qm74	3896	25	in	in	IN
cord-015021-pol2qm74	3896	26	humans	human	NNS
cord-015021-pol2qm74	3896	27	following	follow	VBG
cord-015021-pol2qm74	3896	28	sepsis	sepsis	NN
cord-015021-pol2qm74	3896	29	.	.	.
cord-015021-pol2qm74	3897	1	Other	other	JJ
cord-015021-pol2qm74	3897	2	studies	study	NNS
cord-015021-pol2qm74	3897	3	documented	document	VBD
cord-015021-pol2qm74	3897	4	similar	similar	JJ
cord-015021-pol2qm74	3897	5	changes	change	NNS
cord-015021-pol2qm74	3897	6	in	in	IN
cord-015021-pol2qm74	3897	7	humans	human	NNS
cord-015021-pol2qm74	3897	8	and	and	CC
cord-015021-pol2qm74	3897	9	it	-PRON-	PRP
cord-015021-pol2qm74	3897	10	has	have	VBZ
cord-015021-pol2qm74	3897	11	recently	recently	RB
cord-015021-pol2qm74	3897	12	been	be	VBN
cord-015021-pol2qm74	3897	13	speculated	speculate	VBN
cord-015021-pol2qm74	3897	14	that	that	IN
cord-015021-pol2qm74	3897	15	increasing	increase	VBG
cord-015021-pol2qm74	3897	16	O~	o~	NN
cord-015021-pol2qm74	3897	17	delivery	delivery	NN
cord-015021-pol2qm74	3897	18	might	may	MD
cord-015021-pol2qm74	3897	19	have	have	VB
cord-015021-pol2qm74	3897	20	a	a	DT
cord-015021-pol2qm74	3897	21	favorable	favorable	JJ
cord-015021-pol2qm74	3897	22	impact	impact	NN
cord-015021-pol2qm74	3897	23	on	on	IN
cord-015021-pol2qm74	3897	24	outcome	outcome	NN
cord-015021-pol2qm74	3897	25	.	.	.
cord-015021-pol2qm74	3898	1	At	at	RB
cord-015021-pol2qm74	3898	2	least	least	RBS
cord-015021-pol2qm74	3898	3	three	three	CD
cord-015021-pol2qm74	3898	4	different	different	JJ
cord-015021-pol2qm74	3898	5	explanations	explanation	NNS
cord-015021-pol2qm74	3898	6	have	have	VBP
cord-015021-pol2qm74	3898	7	been	be	VBN
cord-015021-pol2qm74	3898	8	put	put	VBN
cord-015021-pol2qm74	3898	9	forward	forward	RB
cord-015021-pol2qm74	3898	10	as	as	IN
cord-015021-pol2qm74	3898	11	to	to	IN
cord-015021-pol2qm74	3898	12	why	why	WRB
cord-015021-pol2qm74	3898	13	there	there	EX
cord-015021-pol2qm74	3898	14	are	be	VBP
cord-015021-pol2qm74	3898	15	possible	possible	JJ
cord-015021-pol2qm74	3898	16	alterations	alteration	NNS
cord-015021-pol2qm74	3898	17	in	in	IN
cord-015021-pol2qm74	3898	18	energy	energy	NN
cord-015021-pol2qm74	3898	19	metabolism	metabolism	NN
cord-015021-pol2qm74	3898	20	during	during	IN
cord-015021-pol2qm74	3898	21	sepsis	sepsis	NN
cord-015021-pol2qm74	3898	22	.	.	.
cord-015021-pol2qm74	3899	1	These	these	DT
cord-015021-pol2qm74	3899	2	include	include	VBP
cord-015021-pol2qm74	3899	3	decreases	decrease	NNS
cord-015021-pol2qm74	3899	4	in	in	IN
cord-015021-pol2qm74	3899	5	oxygen	oxygen	NN
cord-015021-pol2qm74	3899	6	supply	supply	NN
cord-015021-pol2qm74	3899	7	,	,	,
cord-015021-pol2qm74	3899	8	peripheral	peripheral	JJ
cord-015021-pol2qm74	3899	9	shunts	shunt	NNS
cord-015021-pol2qm74	3899	10	and	and	CC
cord-015021-pol2qm74	3899	11	direct	direct	JJ
cord-015021-pol2qm74	3899	12	action	action	NN
cord-015021-pol2qm74	3899	13	o~	o~	CD
cord-015021-pol2qm74	3899	14	cellular	cellular	JJ
cord-015021-pol2qm74	3899	15	mediators	mediator	NNS
cord-015021-pol2qm74	3899	16	on	on	IN
cord-015021-pol2qm74	3899	17	O~	O~	NNP
cord-015021-pol2qm74	3899	18	delivery	delivery	NN
cord-015021-pol2qm74	3899	19	,	,	,
cord-015021-pol2qm74	3899	20	A	a	DT
cord-015021-pol2qm74	3899	21	provocative	provocative	JJ
cord-015021-pol2qm74	3899	22	review	review	NN
cord-015021-pol2qm74	3899	23	by	by	IN
cord-015021-pol2qm74	3899	24	Hodgkiss	Hodgkiss	NNP
cord-015021-pol2qm74	3899	25	and	and	CC
cord-015021-pol2qm74	3899	26	Nark	Nark	NNP
cord-015021-pol2qm74	3899	27	in	in	IN
cord-015021-pol2qm74	3899	28	1992	1992	CD
cord-015021-pol2qm74	3899	29	shewed	shew	VBD
cord-015021-pol2qm74	3899	30	that	that	IN
cord-015021-pol2qm74	3899	31	in	in	IN
cord-015021-pol2qm74	3899	32	experimental	experimental	JJ
cord-015021-pol2qm74	3899	33	animals	animal	NNS
cord-015021-pol2qm74	3899	34	sepsis	sepsis	NN
cord-015021-pol2qm74	3899	35	did	do	VBD
cord-015021-pol2qm74	3899	36	not	not	RB
cord-015021-pol2qm74	3899	37	cause	cause	VB
cord-015021-pol2qm74	3899	38	any	any	DT
cord-015021-pol2qm74	3899	39	evidence	evidence	NN
cord-015021-pol2qm74	3899	40	of	of	IN
cord-015021-pol2qm74	3899	41	bioenergatic	bioenergatic	JJ
cord-015021-pol2qm74	3899	42	failure	failure	NN
cord-015021-pol2qm74	3899	43	in	in	IN
cord-015021-pol2qm74	3899	44	muscle	muscle	NN
cord-015021-pol2qm74	3899	45	I	-PRON-	PRP
cord-015021-pol2qm74	3899	46	liver	liver	NN
cord-015021-pol2qm74	3899	47	,	,	,
cord-015021-pol2qm74	3899	48	heart	heart	NN
cord-015021-pol2qm74	3899	49	or	or	CC
cord-015021-pol2qm74	3899	50	brain	brain	NN
cord-015021-pol2qm74	3899	51	tissue	tissue	NN
cord-015021-pol2qm74	3899	52	.	.	.
cord-015021-pol2qm74	3900	1	They	-PRON-	PRP
cord-015021-pol2qm74	3900	2	further	further	RB
cord-015021-pol2qm74	3900	3	showed	show	VBD
cord-015021-pol2qm74	3900	4	that	that	IN
cord-015021-pol2qm74	3900	5	the	the	DT
cord-015021-pol2qm74	3900	6	increase	increase	NN
cord-015021-pol2qm74	3900	7	in	in	IN
cord-015021-pol2qm74	3900	8	serum	serum	NN
cord-015021-pol2qm74	3900	9	lactate	lactate	NN
cord-015021-pol2qm74	3900	10	is	be	VBZ
cord-015021-pol2qm74	3900	11	mot	mot	NNP
cord-015021-pol2qm74	3900	12	necessarily	necessarily	RB
cord-015021-pol2qm74	3900	13	due	due	JJ
cord-015021-pol2qm74	3900	14	to	to	IN
cord-015021-pol2qm74	3900	15	cellular	cellular	JJ
cord-015021-pol2qm74	3900	16	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3900	17	.	.	.
cord-015021-pol2qm74	3901	1	They	-PRON-	PRP
cord-015021-pol2qm74	3901	2	conclude	conclude	VBP
cord-015021-pol2qm74	3901	3	that	that	IN
cord-015021-pol2qm74	3901	4	cellular	cellular	JJ
cord-015021-pol2qm74	3901	5	hypoxia	hypoxia	NN
cord-015021-pol2qm74	3901	6	and	and	CC
cord-015021-pol2qm74	3901	7	defects	defect	NNS
cord-015021-pol2qm74	3901	8	in	in	IN
cord-015021-pol2qm74	3901	9	energy	energy	NN
cord-015021-pol2qm74	3901	10	producing	produce	VBG
cord-015021-pol2qm74	3901	11	metabolites	metabolite	NNS
cord-015021-pol2qm74	3901	12	are	be	VBP
cord-015021-pol2qm74	3901	13	not	not	RB
cord-015021-pol2qm74	3901	14	the	the	DT
cord-015021-pol2qm74	3901	15	cause	cause	NN
cord-015021-pol2qm74	3901	16	of	of	IN
cord-015021-pol2qm74	3901	17	metabolic	metabolic	JJ
cord-015021-pol2qm74	3901	18	abnormalities	abnormality	NNS
cord-015021-pol2qm74	3901	19	in	in	IN
cord-015021-pol2qm74	3901	20	sepsis	sepsis	NN
cord-015021-pol2qm74	3901	21	.	.	.
cord-015021-pol2qm74	3902	1	We	-PRON-	PRP
cord-015021-pol2qm74	3902	2	set	set	VBD
cord-015021-pol2qm74	3902	3	out	out	RP
cord-015021-pol2qm74	3902	4	on	on	IN
cord-015021-pol2qm74	3902	5	a	a	DT
cord-015021-pol2qm74	3902	6	series	series	NN
cord-015021-pol2qm74	3902	7	of	of	IN
cord-015021-pol2qm74	3902	8	experiments	experiment	NNS
cord-015021-pol2qm74	3902	9	to	to	TO
cord-015021-pol2qm74	3902	10	try	try	VB
cord-015021-pol2qm74	3902	11	to	to	TO
cord-015021-pol2qm74	3902	12	explain	explain	VB
cord-015021-pol2qm74	3902	13	the	the	DT
cord-015021-pol2qm74	3902	14	paradox	paradox	NN
cord-015021-pol2qm74	3902	15	in	in	IN
cord-015021-pol2qm74	3902	16	cellular	cellular	JJ
cord-015021-pol2qm74	3902	17	metabolism	metabolism	NN
cord-015021-pol2qm74	3902	18	and	and	CC
cord-015021-pol2qm74	3902	19	whether	whether	IN
cord-015021-pol2qm74	3902	20	or	or	CC
cord-015021-pol2qm74	3902	21	not	not	RB
cord-015021-pol2qm74	3902	22	white	white	JJ
cord-015021-pol2qm74	3902	23	cells	cell	NNS
cord-015021-pol2qm74	3902	24	might	may	MD
cord-015021-pol2qm74	3902	25	contribute	contribute	VB
cord-015021-pol2qm74	3902	26	to	to	IN
cord-015021-pol2qm74	3902	27	total	total	JJ
cord-015021-pol2qm74	3902	28	body	body	NN
cord-015021-pol2qm74	3902	29	oxygen	oxygen	NN
cord-015021-pol2qm74	3902	30	consumption	consumption	NN
cord-015021-pol2qm74	3902	31	during	during	IN
cord-015021-pol2qm74	3902	32	sepsis	sepsis	NN
cord-015021-pol2qm74	3902	33	.	.	.
cord-015021-pol2qm74	3903	1	The	the	DT
cord-015021-pol2qm74	3903	2	first	first	JJ
cord-015021-pol2qm74	3903	3	set	set	NN
cord-015021-pol2qm74	3903	4	of	of	IN
cord-015021-pol2qm74	3903	5	experiments	experiment	NNS
cord-015021-pol2qm74	3903	6	involved	involve	VBD
cord-015021-pol2qm74	3903	7	growing	grow	VBG
cord-015021-pol2qm74	3903	8	rat	rat	NN
cord-015021-pol2qm74	3903	9	cardiac	cardiac	JJ
cord-015021-pol2qm74	3903	10	myocytes	myocyte	NNS
cord-015021-pol2qm74	3903	11	on	on	IN
cord-015021-pol2qm74	3903	12	tissue	tissue	NN
cord-015021-pol2qm74	3903	13	culture	culture	NN
cord-015021-pol2qm74	3903	14	.	.	.
cord-015021-pol2qm74	3904	1	Pyruvate	Pyruvate	NNP
cord-015021-pol2qm74	3904	2	was	be	VBD
cord-015021-pol2qm74	3904	3	added	add	VBN
cord-015021-pol2qm74	3904	4	to	to	IN
cord-015021-pol2qm74	3904	5	the	the	DT
cord-015021-pol2qm74	3904	6	medium	medium	NN
cord-015021-pol2qm74	3904	7	as	as	IN
cord-015021-pol2qm74	3904	8	substrata	substrata	NNS
cord-015021-pol2qm74	3904	9	and	and	CC
cord-015021-pol2qm74	3904	10	physiologic	physiologic	JJ
cord-015021-pol2qm74	3904	11	levels	level	NNS
cord-015021-pol2qm74	3904	12	of	of	IN
cord-015021-pol2qm74	3904	13	peroxide	peroxide	NN
cord-015021-pol2qm74	3904	14	were	be	VBD
cord-015021-pol2qm74	3904	15	also	also	RB
cord-015021-pol2qm74	3904	16	added	add	VBN
cord-015021-pol2qm74	3904	17	simultaneously	simultaneously	RB
cord-015021-pol2qm74	3904	18	,	,	,
cord-015021-pol2qm74	3904	19	carbon	carbon	NN
cord-015021-pol2qm74	3904	20	14	14	CD
cord-015021-pol2qm74	3904	21	labeled	label	VBN
cord-015021-pol2qm74	3904	22	CO~	co~	JJ
cord-015021-pol2qm74	3904	23	production	production	NN
cord-015021-pol2qm74	3904	24	was	be	VBD
cord-015021-pol2qm74	3904	25	measured	measure	VBN
cord-015021-pol2qm74	3904	26	as	as	IN
cord-015021-pol2qm74	3904	27	was	be	VBD
cord-015021-pol2qm74	3904	28	nucleotides	nucleotide	NNS
cord-015021-pol2qm74	3904	29	and	and	CC
cord-015021-pol2qm74	3904	30	degradation	degradation	NN
cord-015021-pol2qm74	3904	31	products	product	NNS
cord-015021-pol2qm74	3904	32	from	from	IN
cord-015021-pol2qm74	3904	33	the	the	DT
cord-015021-pol2qm74	3904	34	cell	cell	NN
cord-015021-pol2qm74	3904	35	.	.	.
cord-015021-pol2qm74	3905	1	The	the	DT
cord-015021-pol2qm74	3905	2	peroxide	peroxide	NN
cord-015021-pol2qm74	3905	3	induced	induce	VBD
cord-015021-pol2qm74	3905	4	a	a	DT
cord-015021-pol2qm74	3905	5	significant	significant	JJ
cord-015021-pol2qm74	3905	6	inhibition	inhibition	NN
cord-015021-pol2qm74	3905	7	of	of	IN
cord-015021-pol2qm74	3905	8	pyruvate	pyruvate	NN
cord-015021-pol2qm74	3905	9	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	3905	10	.	.	.
cord-015021-pol2qm74	3906	1	In	in	IN
cord-015021-pol2qm74	3906	2	addition	addition	NN
cord-015021-pol2qm74	3906	3	,	,	,
cord-015021-pol2qm74	3906	4	there	there	EX
cord-015021-pol2qm74	3906	5	was	be	VBD
cord-015021-pol2qm74	3906	6	a	a	DT
cord-015021-pol2qm74	3906	7	loss	loss	NN
cord-015021-pol2qm74	3906	8	of	of	IN
cord-015021-pol2qm74	3906	9	cellular	cellular	JJ
cord-015021-pol2qm74	3906	10	ATP	ATP	NNP
cord-015021-pol2qm74	3906	11	and	and	CC
cord-015021-pol2qm74	3906	12	a	a	DT
cord-015021-pol2qm74	3906	13	corresponding	corresponding	JJ
cord-015021-pol2qm74	3906	14	rise	rise	NN
cord-015021-pol2qm74	3906	15	in	in	IN
cord-015021-pol2qm74	3906	16	the	the	DT
cord-015021-pol2qm74	3906	17	release	release	NN
cord-015021-pol2qm74	3906	18	of	of	IN
cord-015021-pol2qm74	3906	19	inosine	inosine	NN
cord-015021-pol2qm74	3906	20	and	and	CC
cord-015021-pol2qm74	3906	21	adenine	adenine	NN
cord-015021-pol2qm74	3906	22	from	from	IN
cord-015021-pol2qm74	3906	23	the	the	DT
cord-015021-pol2qm74	3906	24	cell	cell	NN
cord-015021-pol2qm74	3906	25	.	.	.
cord-015021-pol2qm74	3907	1	We	-PRON-	PRP
cord-015021-pol2qm74	3907	2	concluded	conclude	VBD
cord-015021-pol2qm74	3907	3	from	from	IN
cord-015021-pol2qm74	3907	4	this	this	DT
cord-015021-pol2qm74	3907	5	first	first	JJ
cord-015021-pol2qm74	3907	6	sst	sst	NN
cord-015021-pol2qm74	3907	7	of	of	IN
cord-015021-pol2qm74	3907	8	experiments	experiment	NNS
cord-015021-pol2qm74	3907	9	that	that	IN
cord-015021-pol2qm74	3907	10	physiologic	physiologic	JJ
cord-015021-pol2qm74	3907	11	levels	level	NNS
cord-015021-pol2qm74	3907	12	of	of	IN
cord-015021-pol2qm74	3907	13	peroxide	peroxide	NN
cord-015021-pol2qm74	3907	14	are	be	VBP
cord-015021-pol2qm74	3907	15	a	a	DT
cord-015021-pol2qm74	3907	16	potent	potent	JJ
cord-015021-pol2qm74	3907	17	inhibitor	inhibitor	NN
cord-015021-pol2qm74	3907	18	of	of	IN
cord-015021-pol2qm74	3907	19	pyruvate	pyruvate	NN
cord-015021-pol2qm74	3907	20	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	3907	21	in	in	IN
cord-015021-pol2qm74	3907	22	isolated	isolated	JJ
cord-015021-pol2qm74	3907	23	cardiac	cardiac	JJ
cord-015021-pol2qm74	3907	24	mitochendria	mitochendria	NNS
cord-015021-pol2qm74	3907	25	as	as	RB
cord-015021-pol2qm74	3907	26	well	well	RB
cord-015021-pol2qm74	3907	27	as	as	IN
cord-015021-pol2qm74	3907	28	the	the	DT
cord-015021-pol2qm74	3907	29	cultured	cultured	JJ
cord-015021-pol2qm74	3907	30	myocyte	myocyte	NNP
cord-015021-pol2qm74	3907	31	.	.	.
cord-015021-pol2qm74	3908	1	We	-PRON-	PRP
cord-015021-pol2qm74	3908	2	further	further	RB
cord-015021-pol2qm74	3908	3	showed	show	VBD
cord-015021-pol2qm74	3908	4	that	that	IN
cord-015021-pol2qm74	3908	5	pyruvate	pyruvate	NN
cord-015021-pol2qm74	3908	6	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	3908	7	inhibition	inhibition	NN
cord-015021-pol2qm74	3908	8	blocks	block	VBZ
cord-015021-pol2qm74	3908	9	the	the	DT
cord-015021-pol2qm74	3908	10	aerobic	aerobic	JJ
cord-015021-pol2qm74	3908	11	oxidation	oxidation	NN
cord-015021-pol2qm74	3908	12	of	of	IN
cord-015021-pol2qm74	3908	13	glucose	glucose	NN
cord-015021-pol2qm74	3908	14	and	and	CC
cord-015021-pol2qm74	3908	15	leads	lead	VBZ
cord-015021-pol2qm74	3908	16	te	te	NNP
cord-015021-pol2qm74	3908	17	adenine	adenine	NN
cord-015021-pol2qm74	3908	18	nucleotide	nucleotide	JJ
cord-015021-pol2qm74	3908	19	metabolism	metabolism	NN
cord-015021-pol2qm74	3908	20	with	with	IN
cord-015021-pol2qm74	3908	21	adenosine	adenosine	NN
cord-015021-pol2qm74	3908	22	and	and	CC
cord-015021-pol2qm74	3908	23	inosine	inosine	JJ
cord-015021-pol2qm74	3908	24	release	release	NN
cord-015021-pol2qm74	3908	25	from	from	IN
cord-015021-pol2qm74	3908	26	the	the	DT
cord-015021-pol2qm74	3908	27	cell	cell	NN
cord-015021-pol2qm74	3908	28	.	.	.
cord-015021-pol2qm74	3909	1	other	other	JJ
cord-015021-pol2qm74	3909	2	enzymes	enzyme	NNS
cord-015021-pol2qm74	3909	3	within	within	IN
cord-015021-pol2qm74	3909	4	the	the	DT
cord-015021-pol2qm74	3909	5	TCA	TCA	NNP
cord-015021-pol2qm74	3909	6	cycle	cycle	NN
cord-015021-pol2qm74	3909	7	did	do	VBD
cord-015021-pol2qm74	3909	8	not	not	RB
cord-015021-pol2qm74	3909	9	appear	appear	VB
cord-015021-pol2qm74	3909	10	to	to	TO
cord-015021-pol2qm74	3909	11	be	be	VB
cord-015021-pol2qm74	3909	12	specifically	specifically	RB
cord-015021-pol2qm74	3909	13	blocked	block	VBN
cord-015021-pol2qm74	3909	14	by	by	IN
cord-015021-pol2qm74	3909	15	peroxide	peroxide	NN
cord-015021-pol2qm74	3909	16	.	.	.
cord-015021-pol2qm74	3910	1	This	this	DT
cord-015021-pol2qm74	3910	2	would	would	MD
cord-015021-pol2qm74	3910	3	explain	explain	VB
cord-015021-pol2qm74	3910	4	the	the	DT
cord-015021-pol2qm74	3910	5	increase	increase	NN
cord-015021-pol2qm74	3910	6	in	in	IN
cord-015021-pol2qm74	3910	7	lactate	lactate	NN
cord-015021-pol2qm74	3910	8	and	and	CC
cord-015021-pol2qm74	3910	9	the	the	DT
cord-015021-pol2qm74	3910	10	ability	ability	NN
cord-015021-pol2qm74	3910	11	of	of	IN
cord-015021-pol2qm74	3910	12	the	the	DT
cord-015021-pol2qm74	3910	13	cell	cell	NN
cord-015021-pol2qm74	3910	14	to	to	TO
cord-015021-pol2qm74	3910	15	continue	continue	VB
cord-015021-pol2qm74	3910	16	to	to	TO
cord-015021-pol2qm74	3910	17	make	make	VB
cord-015021-pol2qm74	3910	18	high	high	JJ
cord-015021-pol2qm74	3910	19	energy	energy	NN
cord-015021-pol2qm74	3910	20	phosphate	phosphate	NN
cord-015021-pol2qm74	3910	21	by	by	IN
cord-015021-pol2qm74	3910	22	entry	entry	NN
cord-015021-pol2qm74	3910	23	of	of	IN
cord-015021-pol2qm74	3910	24	metabolites	metabolite	NNS
cord-015021-pol2qm74	3910	25	in	in	IN
cord-015021-pol2qm74	3910	26	to	to	IN
cord-015021-pol2qm74	3910	27	other	other	JJ
cord-015021-pol2qm74	3910	28	entry	entry	NN
cord-015021-pol2qm74	3910	29	points	point	NNS
cord-015021-pol2qm74	3910	30	of	of	IN
cord-015021-pol2qm74	3910	31	the	the	DT
cord-015021-pol2qm74	3910	32	TCA	TCA	NNP
cord-015021-pol2qm74	3910	33	cycle	cycle	NN
cord-015021-pol2qm74	3910	34	,	,	,
cord-015021-pol2qm74	3910	35	The	the	DT
cord-015021-pol2qm74	3910	36	second	second	JJ
cord-015021-pol2qm74	3910	37	set	set	NN
cord-015021-pol2qm74	3910	38	of	of	IN
cord-015021-pol2qm74	3910	39	experimBnts	experimBnts	NNP
cord-015021-pol2qm74	3910	40	was	be	VBD
cord-015021-pol2qm74	3910	41	designed	design	VBN
cord-015021-pol2qm74	3910	42	to	to	TO
cord-015021-pol2qm74	3910	43	estimate	estimate	VB
cord-015021-pol2qm74	3910	44	the	the	DT
cord-015021-pol2qm74	3910	45	magnitude	magnitude	NN
cord-015021-pol2qm74	3910	46	of	of	IN
cord-015021-pol2qm74	3910	47	whole	whole	JJ
cord-015021-pol2qm74	3910	48	body	body	NN
cord-015021-pol2qm74	3910	49	reactive	reactive	JJ
cord-015021-pol2qm74	3910	50	oxygen	oxygen	NN
cord-015021-pol2qm74	3910	51	generation	generation	NN
cord-015021-pol2qm74	3910	52	via	via	IN
cord-015021-pol2qm74	3910	53	NADPH	NADPH	NNP
cord-015021-pol2qm74	3910	54	oxidase	oxidase	NN
cord-015021-pol2qm74	3910	55	following	follow	VBG
cord-015021-pol2qm74	3910	56	granuloeyte	granuloeyte	NNP
cord-015021-pol2qm74	3910	57	activation	activation	NN
cord-015021-pol2qm74	3910	58	invivo	invivo	NNP
cord-015021-pol2qm74	3910	59	.	.	.
cord-015021-pol2qm74	3911	1	Using	use	VBG
cord-015021-pol2qm74	3911	2	a	a	DT
cord-015021-pol2qm74	3911	3	guinea	guinea	NN
cord-015021-pol2qm74	3911	4	pig	pig	NN
cord-015021-pol2qm74	3911	5	model	model	NN
cord-015021-pol2qm74	3911	6	baseline	baseline	JJ
cord-015021-pol2qm74	3911	7	oxygen	oxygen	NN
cord-015021-pol2qm74	3911	8	consumption	consumption	NN
cord-015021-pol2qm74	3911	9	was	be	VBD
cord-015021-pol2qm74	3911	10	determined	determine	VBN
cord-015021-pol2qm74	3911	11	.	.	.
cord-015021-pol2qm74	3912	1	~iaphenyl	~iaphenyl	NFP
cord-015021-pol2qm74	3912	2	iodinium	iodinium	NNP
cord-015021-pol2qm74	3912	3	(	(	-LRB-
cord-015021-pol2qm74	3912	4	DPI	DPI	NNP
cord-015021-pol2qm74	3912	5	)	)	-RRB-
cord-015021-pol2qm74	3912	6	was	be	VBD
cord-015021-pol2qm74	3912	7	used	use	VBN
cord-015021-pol2qm74	3912	8	as	as	IN
cord-015021-pol2qm74	3912	9	a	a	DT
cord-015021-pol2qm74	3912	10	specific	specific	JJ
cord-015021-pol2qm74	3912	11	inhibitor	inhibitor	NN
cord-015021-pol2qm74	3912	12	of	of	IN
cord-015021-pol2qm74	3912	13	granulocyte	granulocyte	NNP
cord-015021-pol2qm74	3912	14	NADPH	NADPH	NNP
cord-015021-pol2qm74	3912	15	oxidase	oxidase	NN
cord-015021-pol2qm74	3912	16	.	.	.
cord-015021-pol2qm74	3913	1	Animals	animal	NNS
cord-015021-pol2qm74	3913	2	were	be	VBD
cord-015021-pol2qm74	3913	3	divided	divide	VBN
cord-015021-pol2qm74	3913	4	into	into	IN
cord-015021-pol2qm74	3913	5	two	two	CD
cord-015021-pol2qm74	3913	6	groups	group	NNS
cord-015021-pol2qm74	3913	7	;	;	:
cord-015021-pol2qm74	3913	8	those	those	DT
cord-015021-pol2qm74	3913	9	that	that	WDT
cord-015021-pol2qm74	3913	10	received	receive	VBD
cord-015021-pol2qm74	3913	11	DPI	DPI	NNP
cord-015021-pol2qm74	3913	12	and	and	CC
cord-015021-pol2qm74	3913	13	those	those	DT
cord-015021-pol2qm74	3913	14	that	that	WDT
cord-015021-pol2qm74	3913	15	served	serve	VBD
cord-015021-pol2qm74	3913	16	as	as	IN
cord-015021-pol2qm74	3913	17	control	control	NN
cord-015021-pol2qm74	3913	18	,	,	,
cord-015021-pol2qm74	3913	19	All	all	DT
cord-015021-pol2qm74	3913	20	animals	animal	NNS
cord-015021-pol2qm74	3913	21	were	be	VBD
cord-015021-pol2qm74	3913	22	then	then	RB
cord-015021-pol2qm74	3913	23	injected	inject	VBN
cord-015021-pol2qm74	3913	24	with	with	IN
cord-015021-pol2qm74	3913	25	Phorbcl	Phorbcl	NNP
cord-015021-pol2qm74	3913	26	Myristate	Myristate	NNP
cord-015021-pol2qm74	3913	27	Acetate	Acetate	NNP
cord-015021-pol2qm74	3913	28	(	(	-LRB-
cord-015021-pol2qm74	3913	29	pMA	pMA	NNP
cord-015021-pol2qm74	3913	30	)	)	-RRB-
cord-015021-pol2qm74	3913	31	intravenously	intravenously	RB
cord-015021-pol2qm74	3913	32	.	.	.
cord-015021-pol2qm74	3914	1	pMA	pMA	NNP
cord-015021-pol2qm74	3914	2	is	be	VBZ
cord-015021-pol2qm74	3914	3	a	a	DT
cord-015021-pol2qm74	3914	4	potent	potent	JJ
cord-015021-pol2qm74	3914	5	stimulus	stimulus	NN
cord-015021-pol2qm74	3914	6	for	for	IN
cord-015021-pol2qm74	3914	7	granulocyte	granulocyte	NN
cord-015021-pol2qm74	3914	8	activation	activation	NN
cord-015021-pol2qm74	3914	9	and	and	CC
cord-015021-pol2qm74	3914	10	subsequent	subsequent	JJ
cord-015021-pol2qm74	3914	11	reactive	reactive	JJ
cord-015021-pol2qm74	3914	12	oxygen	oxygen	NN
cord-015021-pol2qm74	3914	13	generation	generation	NN
cord-015021-pol2qm74	3914	14	.	.	.
cord-015021-pol2qm74	3915	1	Whole	whole	JJ
cord-015021-pol2qm74	3915	2	body	body	NN
cord-015021-pol2qm74	3915	3	oxygen	oxygen	NN
cord-015021-pol2qm74	3915	4	consumption	consumption	NN
cord-015021-pol2qm74	3915	5	measurements	measurement	NNS
cord-015021-pol2qm74	3915	6	were	be	VBD
cord-015021-pol2qm74	3915	7	then	then	RB
cord-015021-pol2qm74	3915	8	repeated	repeat	VBN
cord-015021-pol2qm74	3915	9	after	after	IN
cord-015021-pol2qm74	3915	10	the	the	DT
cord-015021-pol2qm74	3915	11	P	p	NN
cord-015021-pol2qm74	3915	12	~	~	CD
cord-015021-pol2qm74	3915	13	LA	LA	NNP
cord-015021-pol2qm74	3915	14	injection	injection	NN
cord-015021-pol2qm74	3915	15	.	.	.
cord-015021-pol2qm74	3916	1	In	in	IN
cord-015021-pol2qm74	3916	2	addition	addition	NN
cord-015021-pol2qm74	3916	3	,	,	,
cord-015021-pol2qm74	3916	4	arterial	arterial	JJ
cord-015021-pol2qm74	3916	5	blood	blood	NN
cord-015021-pol2qm74	3916	6	gas	gas	NN
cord-015021-pol2qm74	3916	7	amalysis	amalysis	NN
cord-015021-pol2qm74	3916	8	was	be	VBD
cord-015021-pol2qm74	3916	9	performed	perform	VBN
cord-015021-pol2qm74	3916	10	,	,	,
cord-015021-pol2qm74	3916	11	circulating	circulate	VBG
cord-015021-pol2qm74	3916	12	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	3916	13	were	be	VBD
cord-015021-pol2qm74	3916	14	collected	collect	VBN
cord-015021-pol2qm74	3916	15	and	and	CC
cord-015021-pol2qm74	3916	16	assayed	assay	VBN
cord-015021-pol2qm74	3916	17	for	for	IN
cord-015021-pol2qm74	3916	18	their	-PRON-	PRP$
cord-015021-pol2qm74	3916	19	ability	ability	NN
cord-015021-pol2qm74	3916	20	to	to	TO
cord-015021-pol2qm74	3916	21	generate	generate	VB
cord-015021-pol2qm74	3916	22	hydrogen	hydrogen	NN
cord-015021-pol2qm74	3916	23	peroxide	peroxide	NN
cord-015021-pol2qm74	3916	24	and	and	CC
cord-015021-pol2qm74	3916	25	the	the	DT
cord-015021-pol2qm74	3916	26	r	r	NN
cord-015021-pol2qm74	3916	27	~	~	NFP
cord-015021-pol2qm74	3916	28	ght	ght	NNP
cord-015021-pol2qm74	3916	29	lung	lung	NN
cord-015021-pol2qm74	3916	30	was	be	VBD
cord-015021-pol2qm74	3916	31	removed	remove	VBN
cord-015021-pol2qm74	3916	32	for	for	IN
cord-015021-pol2qm74	3916	33	wet	wet	JJ
cord-015021-pol2qm74	3916	34	and	and	CC
cord-015021-pol2qm74	3916	35	dry	dry	JJ
cord-015021-pol2qm74	3916	36	weight	weight	NN
cord-015021-pol2qm74	3916	37	measurement	measurement	NN
cord-015021-pol2qm74	3916	38	.	.	.
cord-015021-pol2qm74	3917	1	Total	total	JJ
cord-015021-pol2qm74	3917	2	body	body	NN
cord-015021-pol2qm74	3917	3	oxygen	oxygen	NN
cord-015021-pol2qm74	3917	4	consumption	consumption	NN
cord-015021-pol2qm74	3917	5	increased	increase	VBN
cord-015021-pol2qm74	3917	6	by	by	IN
cord-015021-pol2qm74	3917	7	25	25	CD
cord-015021-pol2qm74	3917	8	percent	percent	NN
cord-015021-pol2qm74	3917	9	after	after	IN
cord-015021-pol2qm74	3917	10	PMA	PMA	NNP
cord-015021-pol2qm74	3917	11	injection	injection	NN
cord-015021-pol2qm74	3917	12	.	.	.
cord-015021-pol2qm74	3918	1	Arterial	arterial	JJ
cord-015021-pol2qm74	3918	2	oxygen	oxygen	NN
cord-015021-pol2qm74	3918	3	tension	tension	NN
cord-015021-pol2qm74	3918	4	fell	fall	VBD
cord-015021-pol2qm74	3918	5	significantly	significantly	RB
cord-015021-pol2qm74	3918	6	in	in	IN
cord-015021-pol2qm74	3918	7	the	the	DT
cord-015021-pol2qm74	3918	8	control	control	NN
cord-015021-pol2qm74	3918	9	animal	animal	NN
cord-015021-pol2qm74	3918	10	.	.	.
cord-015021-pol2qm74	3919	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	3919	2	hydrogen	hydrogen	NN
cord-015021-pol2qm74	3919	3	peroxide	peroxide	NN
cord-015021-pol2qm74	3919	4	generation	generation	NN
cord-015021-pol2qm74	3919	5	rate	rate	NN
cord-015021-pol2qm74	3919	6	doubled	double	VBD
cord-015021-pol2qm74	3919	7	and	and	CC
cord-015021-pol2qm74	3919	8	lung	lung	NN
cord-015021-pol2qm74	3919	9	water	water	NN
cord-015021-pol2qm74	3919	10	in	in	IN
cord-015021-pol2qm74	3919	11	the	the	DT
cord-015021-pol2qm74	3919	12	untreated	untreated	JJ
cord-015021-pol2qm74	3919	13	animals	animal	NNS
cord-015021-pol2qm74	3919	14	increased	increase	VBD
cord-015021-pol2qm74	3919	15	by	by	IN
cord-015021-pol2qm74	3919	16	25	25	CD
cord-015021-pol2qm74	3919	17	percent	percent	NN
cord-015021-pol2qm74	3919	18	.	.	.
cord-015021-pol2qm74	3920	1	In	in	IN
cord-015021-pol2qm74	3920	2	this	this	DT
cord-015021-pol2qm74	3920	3	animal	animal	NN
cord-015021-pol2qm74	3920	4	model	model	NN
cord-015021-pol2qm74	3920	5	we	-PRON-	PRP
cord-015021-pol2qm74	3920	6	could	could	MD
cord-015021-pol2qm74	3920	7	show	show	VB
cord-015021-pol2qm74	3920	8	that	that	IN
cord-015021-pol2qm74	3920	9	granulocyte	granulocyte	NN
cord-015021-pol2qm74	3920	10	activation	activation	NN
cord-015021-pol2qm74	3920	11	substantially	substantially	RB
cord-015021-pol2qm74	3920	12	increases	increase	VBZ
cord-015021-pol2qm74	3920	13	whole	whole	JJ
cord-015021-pol2qm74	3920	14	body	body	NN
cord-015021-pol2qm74	3920	15	oxygen	oxygen	NN
cord-015021-pol2qm74	3920	16	consumption	consumption	NN
cord-015021-pol2qm74	3920	17	to	to	IN
cord-015021-pol2qm74	3920	18	approximately	approximately	RB
cord-015021-pol2qm74	3920	19	120	120	CD
cord-015021-pol2qm74	3920	20	percent	percent	NN
cord-015021-pol2qm74	3920	21	of	of	IN
cord-015021-pol2qm74	3920	22	control	control	NN
cord-015021-pol2qm74	3920	23	values	value	NNS
cord-015021-pol2qm74	3920	24	.	.	.
cord-015021-pol2qm74	3921	1	The	the	DT
cord-015021-pol2qm74	3921	2	NADPH	NADPH	NNP
cord-015021-pol2qm74	3921	3	oxidase	oxidase	NN
cord-015021-pol2qm74	3921	4	inhibitor	inhibitor	NN
cord-015021-pol2qm74	3921	5	,	,	,
cord-015021-pol2qm74	3921	6	DPI	DPI	NNP
cord-015021-pol2qm74	3921	7	,	,	,
cord-015021-pol2qm74	3921	8	decreases	decrease	VBZ
cord-015021-pol2qm74	3921	9	granulocyte	granulocyte	NN
cord-015021-pol2qm74	3921	10	hydrogen	hydrogen	NN
cord-015021-pol2qm74	3921	11	peroxide	peroxide	NN
cord-015021-pol2qm74	3921	12	generation	generation	NN
cord-015021-pol2qm74	3921	13	invivo	invivo	NNP
cord-015021-pol2qm74	3921	14	and	and	CC
cord-015021-pol2qm74	3921	15	prevents	prevent	VBZ
cord-015021-pol2qm74	3921	16	the	the	DT
cord-015021-pol2qm74	3921	17	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	3921	18	injury	injury	NN
cord-015021-pol2qm74	3921	19	induced	induce	VBN
cord-015021-pol2qm74	3921	20	by	by	IN
cord-015021-pol2qm74	3921	21	PMA	PMA	NNP
cord-015021-pol2qm74	3921	22	.	.	.
cord-015021-pol2qm74	3922	1	using	use	VBG
cord-015021-pol2qm74	3922	2	this	this	DT
cord-015021-pol2qm74	3922	3	animal	animal	NN
cord-015021-pol2qm74	3922	4	modal	modal	NN
cord-015021-pol2qm74	3922	5	it	-PRON-	PRP
cord-015021-pol2qm74	3922	6	is	be	VBZ
cord-015021-pol2qm74	3922	7	possible	possible	JJ
cord-015021-pol2qm74	3922	8	to	to	TO
cord-015021-pol2qm74	3922	9	transpose	transpose	VB
cord-015021-pol2qm74	3922	10	this	this	DT
cord-015021-pol2qm74	3922	11	to	to	IN
cord-015021-pol2qm74	3922	12	the	the	DT
cord-015021-pol2qm74	3922	13	human	human	JJ
cord-015021-pol2qm74	3922	14	septic	septic	JJ
cord-015021-pol2qm74	3922	15	state	state	NN
cord-015021-pol2qm74	3922	16	.	.	.
cord-015021-pol2qm74	3923	1	If	if	IN
cord-015021-pol2qm74	3923	2	we	-PRON-	PRP
cord-015021-pol2qm74	3923	3	assume	assume	VBP
cord-015021-pol2qm74	3923	4	there	there	EX
cord-015021-pol2qm74	3923	5	are	be	VBP
cord-015021-pol2qm74	3923	6	5,000	5,000	CD
cord-015021-pol2qm74	3923	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	3923	8	per	per	IN
cord-015021-pol2qm74	3923	9	cubic	cubic	JJ
cord-015021-pol2qm74	3923	10	millimeter	millimeter	NN
cord-015021-pol2qm74	3923	11	of	of	IN
cord-015021-pol2qm74	3923	12	blood	blood	NN
cord-015021-pol2qm74	3923	13	,	,	,
cord-015021-pol2qm74	3923	14	a	a	DT
cord-015021-pol2qm74	3923	15	70	70	CD
cord-015021-pol2qm74	3923	16	kg	kg	NN
cord-015021-pol2qm74	3923	17	man	man	NN
cord-015021-pol2qm74	3923	18	would	would	MD
cord-015021-pol2qm74	3923	19	have	have	VB
cord-015021-pol2qm74	3923	20	~1.75XI0	~1.75xi0	CD
cord-015021-pol2qm74	3924	1	u	u	LS
cord-015021-pol2qm74	3924	2	circulating	circulate	VBG
cord-015021-pol2qm74	3924	3	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	3924	4	.	.	.
cord-015021-pol2qm74	3925	1	When	when	WRB
cord-015021-pol2qm74	3925	2	activated	activate	VBN
cord-015021-pol2qm74	3925	3	ixl0	ixl0	NNS
cord-015021-pol2qm74	3925	4	~	~	CD
cord-015021-pol2qm74	3925	5	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	3925	6	generate	generate	VBP
cord-015021-pol2qm74	3925	7	one	one	CD
cord-015021-pol2qm74	3925	8	nanemole	nanemole	NNS
cord-015021-pol2qm74	3925	9	of	of	IN
cord-015021-pol2qm74	3925	10	hydrogen	hydrogen	NN
cord-015021-pol2qm74	3925	11	peroxide	peroxide	NN
cord-015021-pol2qm74	3925	12	per	per	IN
cord-015021-pol2qm74	3925	13	minute	minute	NN
cord-015021-pol2qm74	3925	14	.	.	.
cord-015021-pol2qm74	3926	1	T	T	NNP
cord-015021-pol2qm74	3926	2	~	~	NNP
cord-015021-pol2qm74	3926	3	erefore	erefore	NNP
cord-015021-pol2qm74	3926	4	,	,	,
cord-015021-pol2qm74	3927	1	the	the	DT
cord-015021-pol2qm74	3927	2	circulating	circulate	VBG
cord-015021-pol2qm74	3927	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	3927	4	pool	pool	NN
cord-015021-pol2qm74	3927	5	could	could	MD
cord-015021-pol2qm74	3927	6	generate	generate	VB
cord-015021-pol2qm74	3927	7	-1.75xi0	-1.75xi0	HYPH
cord-015021-pol2qm74	3927	8	nanomoles	nanomole	NNS
cord-015021-pol2qm74	3927	9	of	of	IN
cord-015021-pol2qm74	3927	10	hydrogen	hydrogen	NN
cord-015021-pol2qm74	3927	11	peroxide	peroxide	NN
cord-015021-pol2qm74	3927	12	per	per	IN
cord-015021-pol2qm74	3927	13	minute	minute	NN
cord-015021-pol2qm74	3927	14	.	.	.
cord-015021-pol2qm74	3928	1	This	this	DT
cord-015021-pol2qm74	3928	2	corresponds	correspond	VBZ
cord-015021-pol2qm74	3928	3	to	to	IN
cord-015021-pol2qm74	3928	4	an	an	DT
cord-015021-pol2qm74	3928	5	oxygen	oxygen	NN
cord-015021-pol2qm74	3928	6	consumption	consumption	NN
cord-015021-pol2qm74	3928	7	of	of	IN
cord-015021-pol2qm74	3928	8	-4.2ml	-4.2ml	NFP
cord-015021-pol2qm74	3929	1	/OJmin	/OJmin	NFP
cord-015021-pol2qm74	3929	2	by	by	IN
cord-015021-pol2qm74	3929	3	the	the	DT
cord-015021-pol2qm74	3929	4	circulating	circulate	VBG
cord-015021-pol2qm74	3929	5	neutrophil	neutrophil	NN
cord-015021-pol2qm74	3929	6	pool	pool	NN
cord-015021-pol2qm74	3929	7	alone	alone	RB
cord-015021-pol2qm74	3929	8	.	.	.
cord-015021-pol2qm74	3930	1	This	this	DT
cord-015021-pol2qm74	3930	2	does	do	VBZ
cord-015021-pol2qm74	3930	3	not	not	RB
cord-015021-pol2qm74	3930	4	take	take	VB
cord-015021-pol2qm74	3930	5	into	into	IN
cord-015021-pol2qm74	3930	6	account	account	NN
cord-015021-pol2qm74	3930	7	the	the	DT
cord-015021-pol2qm74	3930	8	production	production	NN
cord-015021-pol2qm74	3930	9	of	of	IN
cord-015021-pol2qm74	3930	10	oxygen	oxygen	NN
cord-015021-pol2qm74	3930	11	by	by	IN
cord-015021-pol2qm74	3930	12	macrophages	macrophage	NNS
cord-015021-pol2qm74	3930	13	or	or	CC
cord-015021-pol2qm74	3930	14	the	the	DT
cord-015021-pol2qm74	3930	15	amount	amount	NN
cord-015021-pol2qm74	3930	16	of	of	IN
cord-015021-pol2qm74	3930	17	oxygen	oxygen	NN
cord-015021-pol2qm74	3930	18	consumed	consume	VBN
cord-015021-pol2qm74	3930	19	to	to	TO
cord-015021-pol2qm74	3930	20	produce	produce	VB
cord-015021-pol2qm74	3930	21	nitric	nitric	NN
cord-015021-pol2qm74	3930	22	oxide	oxide	NN
cord-015021-pol2qm74	3930	23	.	.	.
cord-015021-pol2qm74	3931	1	Manipulation	manipulation	NN
cord-015021-pol2qm74	3931	2	of	of	IN
cord-015021-pol2qm74	3931	3	oxygen	oxygen	NN
cord-015021-pol2qm74	3931	4	delivery	delivery	NN
cord-015021-pol2qm74	3931	5	in	in	IN
cord-015021-pol2qm74	3931	6	human	human	JJ
cord-015021-pol2qm74	3931	7	sepsis	sepsis	NN
cord-015021-pol2qm74	3931	8	may	may	MD
cord-015021-pol2qm74	3931	9	or	or	CC
cord-015021-pol2qm74	3931	10	may	may	MD
cord-015021-pol2qm74	3931	11	not	not	RB
cord-015021-pol2qm74	3931	12	be	be	VB
cord-015021-pol2qm74	3931	13	beneficial	beneficial	JJ
cord-015021-pol2qm74	3931	14	.	.	.
cord-015021-pol2qm74	3932	1	Irshad	Irshad	NNP
cord-015021-pol2qm74	3932	2	H.	H.	NNP
cord-015021-pol2qm74	3932	3	Chaudry	Chaudry	NNP
cord-015021-pol2qm74	3932	4	,	,	,
cord-015021-pol2qm74	3932	5	Ping	Ping	NNP
cord-015021-pol2qm74	3932	6	Wang	Wang	NNP
cord-015021-pol2qm74	3932	7	,	,	,
cord-015021-pol2qm74	3932	8	and	and	CC
cord-015021-pol2qm74	3932	9	Alfred	Alfred	NNP
cord-015021-pol2qm74	3932	10	Ayala	Ayala	NNP
cord-015021-pol2qm74	3932	11	Life	Life	NNP
cord-015021-pol2qm74	3932	12	threatening	threaten	VBG
cord-015021-pol2qm74	3932	13	blood	blood	NN
cord-015021-pol2qm74	3932	14	loss	loss	NN
cord-015021-pol2qm74	3932	15	,	,	,
cord-015021-pol2qm74	3932	16	due	due	IN
cord-015021-pol2qm74	3932	17	to	to	IN
cord-015021-pol2qm74	3932	18	soft	soft	JJ
cord-015021-pol2qm74	3932	19	tissue	tissue	NN
cord-015021-pol2qm74	3932	20	and	and	CC
cord-015021-pol2qm74	3932	21	bony	bony	JJ
cord-015021-pol2qm74	3932	22	injuries	injury	NNS
cord-015021-pol2qm74	3932	23	,	,	,
cord-015021-pol2qm74	3932	24	is	be	VBZ
cord-015021-pol2qm74	3932	25	a	a	DT
cord-015021-pol2qm74	3932	26	frequent	frequent	JJ
cord-015021-pol2qm74	3932	27	complication	complication	NN
cord-015021-pol2qm74	3932	28	in	in	IN
cord-015021-pol2qm74	3932	29	trauma	trauma	NN
cord-015021-pol2qm74	3932	30	victims	victim	NNS
cord-015021-pol2qm74	3932	31	.	.	.
cord-015021-pol2qm74	3933	1	Although	although	IN
cord-015021-pol2qm74	3933	2	numerous	numerous	JJ
cord-015021-pol2qm74	3933	3	organs	organ	NNS
cord-015021-pol2qm74	3933	4	and	and	CC
cord-015021-pol2qm74	3933	5	cells	cell	NNS
cord-015021-pol2qm74	3933	6	are	be	VBP
cord-015021-pol2qm74	3933	7	adversely	adversely	RB
cord-015021-pol2qm74	3933	8	affected	affect	VBN
cord-015021-pol2qm74	3933	9	by	by	IN
cord-015021-pol2qm74	3933	10	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3933	11	,	,	,
cord-015021-pol2qm74	3933	12	the	the	DT
cord-015021-pol2qm74	3933	13	focus	focus	NN
cord-015021-pol2qm74	3933	14	here	here	RB
cord-015021-pol2qm74	3933	15	will	will	MD
cord-015021-pol2qm74	3933	16	be	be	VB
cord-015021-pol2qm74	3933	17	to	to	TO
cord-015021-pol2qm74	3933	18	discuss	discuss	VB
cord-015021-pol2qm74	3933	19	whether	whether	IN
cord-015021-pol2qm74	3933	20	or	or	CC
cord-015021-pol2qm74	3933	21	not	not	RB
cord-015021-pol2qm74	3933	22	there	there	EX
cord-015021-pol2qm74	3933	23	are	be	VBP
cord-015021-pol2qm74	3933	24	any	any	DT
cord-015021-pol2qm74	3933	25	differential	differential	JJ
cord-015021-pol2qm74	3933	26	alterations	alteration	NNS
cord-015021-pol2qm74	3933	27	in	in	IN
cord-015021-pol2qm74	3933	28	splenic	splenic	JJ
cord-015021-pol2qm74	3933	29	and	and	CC
cord-015021-pol2qm74	3933	30	hepatic	hepatic	JJ
cord-015021-pol2qm74	3933	31	immune	immune	JJ
cord-015021-pol2qm74	3933	32	functions	function	NNS
cord-015021-pol2qm74	3933	33	.	.	.
cord-015021-pol2qm74	3934	1	In	in	IN
cord-015021-pol2qm74	3934	2	particular	particular	JJ
cord-015021-pol2qm74	3934	3	,	,	,
cord-015021-pol2qm74	3934	4	M~	M~	NNP
cord-015021-pol2qm74	3934	5	antigen	antigen	NN
cord-015021-pol2qm74	3934	6	presentation	presentation	NN
cord-015021-pol2qm74	3934	7	(	(	-LRB-
cord-015021-pol2qm74	3934	8	AP	AP	NNP
cord-015021-pol2qm74	3934	9	)	)	-RRB-
cord-015021-pol2qm74	3934	10	and	and	CC
cord-015021-pol2qm74	3934	11	associated	associated	JJ
cord-015021-pol2qm74	3934	12	processes	process	NNS
cord-015021-pol2qm74	3934	13	will	will	MD
cord-015021-pol2qm74	3934	14	be	be	VB
cord-015021-pol2qm74	3934	15	described	describe	VBN
cord-015021-pol2qm74	3934	16	since	since	IN
cord-015021-pol2qm74	3934	17	one	one	CD
cord-015021-pol2qm74	3934	18	of	of	IN
cord-015021-pol2qm74	3934	19	the	the	DT
cord-015021-pol2qm74	3934	20	important	important	JJ
cord-015021-pol2qm74	3934	21	functions	function	NNS
cord-015021-pol2qm74	3934	22	of	of	IN
cord-015021-pol2qm74	3934	23	the	the	DT
cord-015021-pol2qm74	3934	24	M6	M6	NNP
cord-015021-pol2qm74	3934	25	is	be	VBZ
cord-015021-pol2qm74	3934	26	to	to	TO
cord-015021-pol2qm74	3934	27	activate	activate	VB
cord-015021-pol2qm74	3934	28	resting	rest	VBG
cord-015021-pol2qm74	3934	29	T	t	NN
cord-015021-pol2qm74	3934	30	-	-	HYPH
cord-015021-pol2qm74	3934	31	cell	cell	NN
cord-015021-pol2qm74	3934	32	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	3934	33	by	by	IN
cord-015021-pol2qm74	3934	34	processing	process	VBG
cord-015021-pol2qm74	3934	35	and	and	CC
cord-015021-pol2qm74	3934	36	presenting	present	VBG
cord-015021-pol2qm74	3934	37	foreign	foreign	JJ
cord-015021-pol2qm74	3934	38	antigens	antigen	NNS
cord-015021-pol2qm74	3934	39	in	in	IN
cord-015021-pol2qm74	3934	40	a	a	DT
cord-015021-pol2qm74	3934	41	MHC	MHC	NNP
cord-015021-pol2qm74	3934	42	Class	Class	NNP
cord-015021-pol2qm74	3934	43	II	ii	NN
cord-015021-pol2qm74	3934	44	-	-	HYPH
cord-015021-pol2qm74	3934	45	restricted	restrict	VBN
cord-015021-pol2qm74	3934	46	fashion	fashion	NN
cord-015021-pol2qm74	3934	47	.	.	.
cord-015021-pol2qm74	3935	1	Studies	study	NNS
cord-015021-pol2qm74	3935	2	have	have	VBP
cord-015021-pol2qm74	3935	3	shown	show	VBN
cord-015021-pol2qm74	3935	4	that	that	IN
cord-015021-pol2qm74	3935	5	splenic	splenic	JJ
cord-015021-pol2qm74	3935	6	M6	M6	NNP
cord-015021-pol2qm74	3935	7	and	and	CC
cord-015021-pol2qm74	3935	8	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	3935	9	cell	cell	NN
cord-015021-pol2qm74	3935	10	(	(	-LRB-
cord-015021-pol2qm74	3935	11	KC	KC	NNP
cord-015021-pol2qm74	3935	12	)	)	-RRB-
cord-015021-pol2qm74	3935	13	AP	AP	NNP
cord-015021-pol2qm74	3935	14	was	be	VBD
cord-015021-pol2qm74	3935	15	significantly	significantly	RB
cord-015021-pol2qm74	3935	16	depressed	depress	VBN
cord-015021-pol2qm74	3935	17	following	follow	VBG
cord-015021-pol2qm74	3935	18	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	3935	19	shock	shock	NN
cord-015021-pol2qm74	3935	20	and	and	CC
cord-015021-pol2qm74	3935	21	remained	remain	VBD
cord-015021-pol2qm74	3935	22	so	so	RB
cord-015021-pol2qm74	3935	23	for	for	IN
cord-015021-pol2qm74	3935	24	at	at	RB
cord-015021-pol2qm74	3935	25	least	least	JJS
cord-015021-pol2qm74	3935	26	96	96	CD
cord-015021-pol2qm74	3935	27	h	h	NN
cord-015021-pol2qm74	3935	28	alter	alter	VB
cord-015021-pol2qm74	3935	29	resuscitation	resuscitation	NN
cord-015021-pol2qm74	3935	30	.	.	.
cord-015021-pol2qm74	3936	1	The	the	DT
cord-015021-pol2qm74	3936	2	presentation	presentation	NN
cord-015021-pol2qm74	3936	3	of	of	IN
cord-015021-pol2qm74	3936	4	antigenic	antigenic	JJ
cord-015021-pol2qm74	3936	5	fragments	fragment	NNS
cord-015021-pol2qm74	3936	6	associated	associate	VBN
cord-015021-pol2qm74	3936	7	with	with	IN
cord-015021-pol2qm74	3936	8	MHC	MHC	NNP
cord-015021-pol2qm74	3936	9	Class	Class	NNP
cord-015021-pol2qm74	3936	10	II	II	NNP
cord-015021-pol2qm74	3936	11	antigen	antigen	NN
cord-015021-pol2qm74	3936	12	itself	-PRON-	PRP
cord-015021-pol2qm74	3936	13	was	be	VBD
cord-015021-pol2qm74	3936	14	not	not	RB
cord-015021-pol2qm74	3936	15	decreased	decrease	VBN
cord-015021-pol2qm74	3936	16	following	follow	VBG
cord-015021-pol2qm74	3936	17	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3936	18	,	,	,
cord-015021-pol2qm74	3936	19	but	but	CC
cord-015021-pol2qm74	3936	20	the	the	DT
cord-015021-pol2qm74	3936	21	catabolism	catabolism	NN
cord-015021-pol2qm74	3936	22	of	of	IN
cord-015021-pol2qm74	3936	23	antigens	antigen	NNS
cord-015021-pol2qm74	3936	24	in	in	IN
cord-015021-pol2qm74	3936	25	antigen	antigen	NN
cord-015021-pol2qm74	3936	26	-	-	HYPH
cord-015021-pol2qm74	3936	27	presenting	present	VBG
cord-015021-pol2qm74	3936	28	cells	cell	NNS
cord-015021-pol2qm74	3936	29	was	be	VBD
cord-015021-pol2qm74	3936	30	decreased	decrease	VBN
cord-015021-pol2qm74	3936	31	.	.	.
cord-015021-pol2qm74	3937	1	This	this	DT
cord-015021-pol2qm74	3937	2	is	be	VBZ
cord-015021-pol2qm74	3937	3	likely	likely	JJ
cord-015021-pol2qm74	3937	4	due	due	IN
cord-015021-pol2qm74	3937	5	to	to	IN
cord-015021-pol2qm74	3937	6	a	a	DT
cord-015021-pol2qm74	3937	7	significant	significant	JJ
cord-015021-pol2qm74	3937	8	loss	loss	NN
cord-015021-pol2qm74	3937	9	of	of	IN
cord-015021-pol2qm74	3937	10	cellular	cellular	JJ
cord-015021-pol2qm74	3937	11	ATP	ATP	NNP
cord-015021-pol2qm74	3937	12	.	.	.
cord-015021-pol2qm74	3938	1	Although	although	IN
cord-015021-pol2qm74	3938	2	M6	M6	NNP
cord-015021-pol2qm74	3938	3	AP	AP	NNP
cord-015021-pol2qm74	3938	4	was	be	VBD
cord-015021-pol2qm74	3938	5	depressed	depress	VBN
cord-015021-pol2qm74	3938	6	in	in	IN
cord-015021-pol2qm74	3938	7	splenic	splenic	JJ
cord-015021-pol2qm74	3938	8	,	,	,
cord-015021-pol2qm74	3938	9	as	as	RB
cord-015021-pol2qm74	3938	10	well	well	RB
cord-015021-pol2qm74	3938	11	as	as	IN
cord-015021-pol2qm74	3938	12	KC	KC	NNP
cord-015021-pol2qm74	3938	13	,	,	,
cord-015021-pol2qm74	3938	14	only	only	RB
cord-015021-pol2qm74	3938	15	KC	KC	NNP
cord-015021-pol2qm74	3938	16	showed	show	VBD
cord-015021-pol2qm74	3938	17	an	an	DT
cord-015021-pol2qm74	3938	18	enhanced	enhance	VBN
cord-015021-pol2qm74	3938	19	capacity	capacity	NN
cord-015021-pol2qm74	3938	20	to	to	TO
cord-015021-pol2qm74	3938	21	produce	produce	VB
cord-015021-pol2qm74	3938	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3938	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	3938	24	,	,	,
cord-015021-pol2qm74	3938	25	IL-1	IL-1	NNP
cord-015021-pol2qm74	3938	26	,	,	,
cord-015021-pol2qm74	3938	27	IL-6	IL-6	NNP
cord-015021-pol2qm74	3938	28	,	,	,
cord-015021-pol2qm74	3938	29	and	and	CC
cord-015021-pol2qm74	3938	30	TNF	TNF	NNP
cord-015021-pol2qm74	3938	31	.	.	.
cord-015021-pol2qm74	3939	1	This	this	DT
cord-015021-pol2qm74	3939	2	difference	difference	NN
cord-015021-pol2qm74	3939	3	in	in	IN
cord-015021-pol2qm74	3939	4	response	response	NN
cord-015021-pol2qm74	3939	5	between	between	IN
cord-015021-pol2qm74	3939	6	KC	KC	NNP
cord-015021-pol2qm74	3939	7	and	and	CC
cord-015021-pol2qm74	3939	8	splenic	splenic	JJ
cord-015021-pol2qm74	3939	9	Md	Md	NNP
cord-015021-pol2qm74	3939	10	may	may	MD
cord-015021-pol2qm74	3939	11	be	be	VB
cord-015021-pol2qm74	3939	12	due	due	JJ
cord-015021-pol2qm74	3939	13	to	to	IN
cord-015021-pol2qm74	3939	14	differences	difference	NNS
cord-015021-pol2qm74	3939	15	in	in	IN
cord-015021-pol2qm74	3939	16	the	the	DT
cord-015021-pol2qm74	3939	17	microenvironment	microenvironment	NN
cord-015021-pol2qm74	3939	18	in	in	IN
cord-015021-pol2qm74	3939	19	which	which	WDT
cord-015021-pol2qm74	3939	20	these	these	DT
cord-015021-pol2qm74	3939	21	cell	cell	NN
cord-015021-pol2qm74	3939	22	populations	population	NNS
cord-015021-pol2qm74	3939	23	are	be	VBP
cord-015021-pol2qm74	3939	24	found	find	VBN
cord-015021-pol2qm74	3939	25	,	,	,
cord-015021-pol2qm74	3939	26	as	as	RB
cord-015021-pol2qm74	3939	27	well	well	RB
cord-015021-pol2qm74	3939	28	as	as	IN
cord-015021-pol2qm74	3939	29	potential	potential	JJ
cord-015021-pol2qm74	3939	30	differences	difference	NNS
cord-015021-pol2qm74	3939	31	in	in	IN
cord-015021-pol2qm74	3939	32	the	the	DT
cord-015021-pol2qm74	3939	33	effects	effect	NNS
cord-015021-pol2qm74	3939	34	that	that	WDT
cord-015021-pol2qm74	3939	35	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3939	36	has	have	VBZ
cord-015021-pol2qm74	3939	37	on	on	IN
cord-015021-pol2qm74	3939	38	the	the	DT
cord-015021-pol2qm74	3939	39	environment	environment	NN
cord-015021-pol2qm74	3939	40	from	from	IN
cord-015021-pol2qm74	3939	41	which	which	WDT
cord-015021-pol2qm74	3939	42	these	these	DT
cord-015021-pol2qm74	3939	43	cells	cell	NNS
cord-015021-pol2qm74	3939	44	are	be	VBP
cord-015021-pol2qm74	3939	45	obtained	obtain	VBN
cord-015021-pol2qm74	3939	46	.	.	.
cord-015021-pol2qm74	3940	1	Splenic	Splenic	NNP
cord-015021-pol2qm74	3940	2	M6	M6	NNP
cord-015021-pol2qm74	3940	3	from	from	IN
cord-015021-pol2qm74	3940	4	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3940	5	-	-	HYPH
cord-015021-pol2qm74	3940	6	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	3940	7	mice	mouse	NNS
cord-015021-pol2qm74	3940	8	exhibited	exhibit	VBD
cord-015021-pol2qm74	3940	9	a	a	DT
cord-015021-pol2qm74	3940	10	significantly	significantly	RB
cord-015021-pol2qm74	3940	11	reduced	reduce	VBN
cord-015021-pol2qm74	3940	12	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	3940	13	response	response	NN
cord-015021-pol2qm74	3940	14	,	,	,
cord-015021-pol2qm74	3940	15	whereas	whereas	IN
cord-015021-pol2qm74	3940	16	KC	KC	NNP
cord-015021-pol2qm74	3940	17	showed	show	VBD
cord-015021-pol2qm74	3940	18	an	an	DT
cord-015021-pol2qm74	3940	19	enhanced	enhance	VBN
cord-015021-pol2qm74	3940	20	cytotuxic	cytotuxic	NN
cord-015021-pol2qm74	3940	21	capacity	capacity	NN
cord-015021-pol2qm74	3940	22	.	.	.
cord-015021-pol2qm74	3941	1	The	the	DT
cord-015021-pol2qm74	3941	2	increased	increase	VBN
cord-015021-pol2qm74	3941	3	KC	KC	NNP
cord-015021-pol2qm74	3941	4	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	3941	5	is	be	VBZ
cord-015021-pol2qm74	3941	6	probably	probably	RB
cord-015021-pol2qm74	3941	7	mediated	mediate	VBN
cord-015021-pol2qm74	3941	8	through	through	IN
cord-015021-pol2qm74	3941	9	the	the	DT
cord-015021-pol2qm74	3941	10	increased	increase	VBN
cord-015021-pol2qm74	3941	11	expression	expression	NN
cord-015021-pol2qm74	3941	12	of	of	IN
cord-015021-pol2qm74	3941	13	cell	cell	NN
cord-015021-pol2qm74	3941	14	-	-	HYPH
cord-015021-pol2qm74	3941	15	associated	associate	VBN
cord-015021-pol2qm74	3941	16	TNF	TNF	NNP
cord-015021-pol2qm74	3941	17	and	and	CC
cord-015021-pol2qm74	3941	18	the	the	DT
cord-015021-pol2qm74	3941	19	release	release	NN
cord-015021-pol2qm74	3941	20	of	of	IN
cord-015021-pol2qm74	3941	21	reactive	reactive	JJ
cord-015021-pol2qm74	3941	22	nitrogen	nitrogen	NN
cord-015021-pol2qm74	3941	23	.	.	.
cord-015021-pol2qm74	3942	1	The	the	DT
cord-015021-pol2qm74	3942	2	enhanced	enhanced	JJ
cord-015021-pol2qm74	3942	3	production	production	NN
cord-015021-pol2qm74	3942	4	of	of	IN
cord-015021-pol2qm74	3942	5	reactive	reactive	JJ
cord-015021-pol2qm74	3942	6	nitrogen	nitrogen	NN
cord-015021-pol2qm74	3942	7	may	may	MD
cord-015021-pol2qm74	3942	8	play	play	VB
cord-015021-pol2qm74	3942	9	an	an	DT
cord-015021-pol2qm74	3942	10	important	important	JJ
cord-015021-pol2qm74	3942	11	role	role	NN
cord-015021-pol2qm74	3942	12	in	in	IN
cord-015021-pol2qm74	3942	13	the	the	DT
cord-015021-pol2qm74	3942	14	clearance	clearance	NN
cord-015021-pol2qm74	3942	15	of	of	IN
cord-015021-pol2qm74	3942	16	microbes	microbe	NNS
cord-015021-pol2qm74	3942	17	translocated	translocate	VBN
cord-015021-pol2qm74	3942	18	from	from	IN
cord-015021-pol2qm74	3942	19	the	the	DT
cord-015021-pol2qm74	3942	20	gut	gut	NN
cord-015021-pol2qm74	3942	21	following	follow	VBG
cord-015021-pol2qm74	3942	22	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3942	23	.	.	.
cord-015021-pol2qm74	3943	1	However	however	RB
cord-015021-pol2qm74	3943	2	,	,	,
cord-015021-pol2qm74	3943	3	excessive	excessive	JJ
cord-015021-pol2qm74	3943	4	release	release	NN
cord-015021-pol2qm74	3943	5	of	of	IN
cord-015021-pol2qm74	3943	6	reactive	reactive	JJ
cord-015021-pol2qm74	3943	7	nitrogen	nitrogen	NN
cord-015021-pol2qm74	3943	8	by	by	IN
cord-015021-pol2qm74	3943	9	KC	KC	NNP
cord-015021-pol2qm74	3943	10	may	may	MD
cord-015021-pol2qm74	3943	11	have	have	VB
cord-015021-pol2qm74	3943	12	deleterious	deleterious	JJ
cord-015021-pol2qm74	3943	13	effects	effect	NNS
cord-015021-pol2qm74	3943	14	on	on	IN
cord-015021-pol2qm74	3943	15	the	the	DT
cord-015021-pol2qm74	3943	16	adjacent	adjacent	JJ
cord-015021-pol2qm74	3943	17	hepatncytes	hepatncyte	NNS
cord-015021-pol2qm74	3943	18	.	.	.
cord-015021-pol2qm74	3944	1	Such	such	PDT
cord-015021-pol2qm74	3944	2	an	an	DT
cord-015021-pol2qm74	3944	3	effect	effect	NN
cord-015021-pol2qm74	3944	4	could	could	MD
cord-015021-pol2qm74	3944	5	,	,	,
cord-015021-pol2qm74	3944	6	in	in	IN
cord-015021-pol2qm74	3944	7	part	part	NN
cord-015021-pol2qm74	3944	8	,	,	,
cord-015021-pol2qm74	3944	9	explain	explain	VB
cord-015021-pol2qm74	3944	10	the	the	DT
cord-015021-pol2qm74	3944	11	reduction	reduction	NN
cord-015021-pol2qm74	3944	12	in	in	IN
cord-015021-pol2qm74	3944	13	active	active	JJ
cord-015021-pol2qm74	3944	14	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	3944	15	function	function	NN
cord-015021-pol2qm74	3944	16	,	,	,
cord-015021-pol2qm74	3944	17	which	which	WDT
cord-015021-pol2qm74	3944	18	is	be	VBZ
cord-015021-pol2qm74	3944	19	seen	see	VBN
cord-015021-pol2qm74	3944	20	following	follow	VBG
cord-015021-pol2qm74	3944	21	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3944	22	-	-	HYPH
cord-015021-pol2qm74	3944	23	resuscitation	resuscitation	NN
cord-015021-pol2qm74	3944	24	.	.	.
cord-015021-pol2qm74	3945	1	Thus	thus	RB
cord-015021-pol2qm74	3945	2	,	,	,
cord-015021-pol2qm74	3945	3	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3945	4	induces	induce	VBZ
cord-015021-pol2qm74	3945	5	differential	differential	JJ
cord-015021-pol2qm74	3945	6	effects	effect	NNS
cord-015021-pol2qm74	3945	7	on	on	IN
cord-015021-pol2qm74	3945	8	splenic	splenic	JJ
cord-015021-pol2qm74	3945	9	and	and	CC
cord-015021-pol2qm74	3945	10	KC	KC	NNP
cord-015021-pol2qm74	3945	11	M6	M6	NNP
cord-015021-pol2qm74	3945	12	populations	population	NNS
cord-015021-pol2qm74	3945	13	;	;	:
cord-015021-pol2qm74	3945	14	it	-PRON-	PRP
cord-015021-pol2qm74	3945	15	decreases	decrease	VBZ
cord-015021-pol2qm74	3945	16	splenic	splenic	JJ
cord-015021-pol2qm74	3945	17	M6	M6	NNP
cord-015021-pol2qm74	3945	18	but	but	CC
cord-015021-pol2qm74	3945	19	increases	increase	VBZ
cord-015021-pol2qm74	3945	20	KC	KC	NNP
cord-015021-pol2qm74	3945	21	capacity	capacity	NN
cord-015021-pol2qm74	3945	22	to	to	TO
cord-015021-pol2qm74	3945	23	mount	mount	VB
cord-015021-pol2qm74	3945	24	a	a	DT
cord-015021-pol2qm74	3945	25	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	3945	26	response	response	NN
cord-015021-pol2qm74	3945	27	.	.	.
cord-015021-pol2qm74	3946	1	The	the	DT
cord-015021-pol2qm74	3946	2	depressed	depressed	JJ
cord-015021-pol2qm74	3946	3	splenic	splenic	JJ
cord-015021-pol2qm74	3946	4	Md	Md	NNP
cord-015021-pol2qm74	3946	5	and	and	CC
cord-015021-pol2qm74	3946	6	KC	KC	NNP
cord-015021-pol2qm74	3946	7	AP	AP	NNP
cord-015021-pol2qm74	3946	8	was	be	VBD
cord-015021-pol2qm74	3946	9	,	,	,
cord-015021-pol2qm74	3946	10	however	however	RB
cord-015021-pol2qm74	3946	11	,	,	,
cord-015021-pol2qm74	3946	12	significantly	significantly	RB
cord-015021-pol2qm74	3946	13	improved	improve	VBN
cord-015021-pol2qm74	3946	14	by	by	IN
cord-015021-pol2qm74	3946	15	posttreatment	posttreatment	NN
cord-015021-pol2qm74	3946	16	of	of	IN
cord-015021-pol2qm74	3946	17	animals	animal	NNS
cord-015021-pol2qm74	3946	18	with	with	IN
cord-015021-pol2qm74	3946	19	ATP	ATP	NNP
cord-015021-pol2qm74	3946	20	-	-	HYPH
cord-015021-pol2qm74	3946	21	MgCIa	MgCIa	NNP
cord-015021-pol2qm74	3946	22	,	,	,
cord-015021-pol2qm74	3946	23	chloroquine	chloroquine	NN
cord-015021-pol2qm74	3946	24	,	,	,
cord-015021-pol2qm74	3946	25	diltiazem	diltiazem	NN
cord-015021-pol2qm74	3946	26	or	or	CC
cord-015021-pol2qm74	3946	27	interferon-'/.	interferon-'/.	VBN
cord-015021-pol2qm74	3946	28	These	these	DT
cord-015021-pol2qm74	3946	29	agents	agent	NNS
cord-015021-pol2qm74	3946	30	also	also	RB
cord-015021-pol2qm74	3946	31	decreased	decrease	VBD
cord-015021-pol2qm74	3946	32	the	the	DT
cord-015021-pol2qm74	3946	33	susceptibility	susceptibility	NN
cord-015021-pol2qm74	3946	34	to	to	IN
cord-015021-pol2qm74	3946	35	sepsis	sepsis	NN
cord-015021-pol2qm74	3946	36	following	follow	VBG
cord-015021-pol2qm74	3946	37	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	3946	38	.	.	.
cord-015021-pol2qm74	3947	1	Thus	thus	RB
cord-015021-pol2qm74	3947	2	,	,	,
cord-015021-pol2qm74	3947	3	the	the	DT
cord-015021-pol2qm74	3947	4	use	use	NN
cord-015021-pol2qm74	3947	5	of	of	IN
cord-015021-pol2qm74	3947	6	ATP	ATP	NNP
cord-015021-pol2qm74	3947	7	-	-	HYPH
cord-015021-pol2qm74	3947	8	MgCI~	MgCI~	NNP
cord-015021-pol2qm74	3947	9	,	,	,
cord-015021-pol2qm74	3947	10	dfltiazem	dfltiazem	NNS
cord-015021-pol2qm74	3947	11	,	,	,
cord-015021-pol2qm74	3947	12	chloroquine	chloroquine	NN
cord-015021-pol2qm74	3947	13	or	or	CC
cord-015021-pol2qm74	3947	14	interferon-7	interferon-7	NNP
cord-015021-pol2qm74	3947	15	offers	offer	VBZ
cord-015021-pol2qm74	3947	16	new	new	JJ
cord-015021-pol2qm74	3947	17	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	3947	18	modalities	modality	NNS
cord-015021-pol2qm74	3947	19	in	in	IN
cord-015021-pol2qm74	3947	20	the	the	DT
cord-015021-pol2qm74	3947	21	treatment	treatment	NN
cord-015021-pol2qm74	3947	22	of	of	IN
cord-015021-pol2qm74	3947	23	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	3947	24	and	and	CC
cord-015021-pol2qm74	3947	25	for	for	IN
cord-015021-pol2qm74	3947	26	decreasing	decrease	VBG
cord-015021-pol2qm74	3947	27	the	the	DT
cord-015021-pol2qm74	3947	28	susceptibility	susceptibility	NN
cord-015021-pol2qm74	3947	29	to	to	IN
cord-015021-pol2qm74	3947	30	sepsis	sepsis	NN
cord-015021-pol2qm74	3947	31	,	,	,
cord-015021-pol2qm74	3947	32	which	which	WDT
cord-015021-pol2qm74	3947	33	is	be	VBZ
cord-015021-pol2qm74	3947	34	observed	observe	VBN
cord-015021-pol2qm74	3947	35	following	follow	VBG
cord-015021-pol2qm74	3947	36	severe	severe	JJ
cord-015021-pol2qm74	3947	37	blood	blood	NN
cord-015021-pol2qm74	3947	38	loss	loss	NN
cord-015021-pol2qm74	3947	39	.	.	.
cord-015021-pol2qm74	3948	1	The	the	DT
cord-015021-pol2qm74	3948	2	production	production	NN
cord-015021-pol2qm74	3948	3	of	of	IN
cord-015021-pol2qm74	3948	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	3948	5	from	from	IN
cord-015021-pol2qm74	3948	6	bone	bone	NN
cord-015021-pol2qm74	3948	7	marrow	marrow	NN
cord-015021-pol2qm74	3948	8	precursor	precursor	NN
cord-015021-pol2qm74	3948	9	cells	cell	NNS
cord-015021-pol2qm74	3948	10	is	be	VBZ
cord-015021-pol2qm74	3948	11	a	a	DT
cord-015021-pol2qm74	3948	12	dynamic	dynamic	JJ
cord-015021-pol2qm74	3948	13	and	and	CC
cord-015021-pol2qm74	3948	14	highly	highly	RB
cord-015021-pol2qm74	3948	15	regulated	regulated	JJ
cord-015021-pol2qm74	3948	16	process	process	NN
cord-015021-pol2qm74	3948	17	.	.	.
cord-015021-pol2qm74	3949	1	The	the	DT
cord-015021-pol2qm74	3949	2	differentiation	differentiation	NN
cord-015021-pol2qm74	3949	3	of	of	IN
cord-015021-pol2qm74	3949	4	myeloid	myeloid	JJ
cord-015021-pol2qm74	3949	5	lineage	lineage	NN
cord-015021-pol2qm74	3949	6	-	-	HYPH
cord-015021-pol2qm74	3949	7	restricted	restrict	VBN
cord-015021-pol2qm74	3949	8	progenitor	progenitor	NN
cord-015021-pol2qm74	3949	9	cells	cell	NNS
cord-015021-pol2qm74	3949	10	is	be	VBZ
cord-015021-pol2qm74	3949	11	initially	initially	RB
cord-015021-pol2qm74	3949	12	controlled	control	VBN
cord-015021-pol2qm74	3949	13	by	by	IN
cord-015021-pol2qm74	3949	14	interleukin-3	interleukin-3	NNP
cord-015021-pol2qm74	3949	15	,	,	,
cord-015021-pol2qm74	3949	16	which	which	WDT
cord-015021-pol2qm74	3949	17	drives	drive	VBZ
cord-015021-pol2qm74	3949	18	the	the	DT
cord-015021-pol2qm74	3949	19	progenitors	progenitor	NNS
cord-015021-pol2qm74	3949	20	along	along	IN
cord-015021-pol2qm74	3949	21	a	a	DT
cord-015021-pol2qm74	3949	22	maturation	maturation	NN
cord-015021-pol2qm74	3949	23	pathway	pathway	NN
cord-015021-pol2qm74	3949	24	that	that	WDT
cord-015021-pol2qm74	3949	25	leads	lead	VBZ
cord-015021-pol2qm74	3949	26	to	to	IN
cord-015021-pol2qm74	3949	27	their	-PRON-	PRP$
cord-015021-pol2qm74	3949	28	response	response	NN
cord-015021-pol2qm74	3949	29	to	to	IN
cord-015021-pol2qm74	3949	30	specific	specific	JJ
cord-015021-pol2qm74	3949	31	lineagerestricted	lineagerestricted	JJ
cord-015021-pol2qm74	3949	32	colony	colony	NN
cord-015021-pol2qm74	3949	33	-	-	HYPH
cord-015021-pol2qm74	3949	34	stimulating	stimulate	VBG
cord-015021-pol2qm74	3949	35	factors(CSFs	factors(csfs	CD
cord-015021-pol2qm74	3949	36	)	)	-RRB-
cord-015021-pol2qm74	3950	1	We	-PRON-	PRP
cord-015021-pol2qm74	3950	2	have	have	VBP
cord-015021-pol2qm74	3950	3	previously	previously	RB
cord-015021-pol2qm74	3950	4	hypothesized	hypothesize	VBN
cord-015021-pol2qm74	3950	5	that	that	IN
cord-015021-pol2qm74	3950	6	thermal	thermal	JJ
cord-015021-pol2qm74	3950	7	injury	injury	NN
cord-015021-pol2qm74	3950	8	can	can	MD
cord-015021-pol2qm74	3950	9	initiate	initiate	VB
cord-015021-pol2qm74	3950	10	a	a	DT
cord-015021-pol2qm74	3950	11	self	self	NN
cord-015021-pol2qm74	3950	12	perpetuating	perpetuate	VBG
cord-015021-pol2qm74	3950	13	cycle	cycle	NN
cord-015021-pol2qm74	3950	14	of	of	IN
cord-015021-pol2qm74	3950	15	production	production	NN
cord-015021-pol2qm74	3950	16	of	of	IN
cord-015021-pol2qm74	3950	17	defective	defective	JJ
cord-015021-pol2qm74	3950	18	immune	immune	JJ
cord-015021-pol2qm74	3950	19	cells	cell	NNS
cord-015021-pol2qm74	3950	20	:	:	:
cord-015021-pol2qm74	3950	21	Thermal	thermal	JJ
cord-015021-pol2qm74	3950	22	injury	injury	NN
cord-015021-pol2qm74	3950	23	can	can	MD
cord-015021-pol2qm74	3950	24	initially	initially	RB
cord-015021-pol2qm74	3950	25	affect	affect	VB
cord-015021-pol2qm74	3950	26	circulating	circulate	VBG
cord-015021-pol2qm74	3950	27	immune	immune	JJ
cord-015021-pol2qm74	3950	28	cells	cell	NNS
cord-015021-pol2qm74	3950	29	.	.	.
cord-015021-pol2qm74	3951	1	Then	then	RB
cord-015021-pol2qm74	3951	2	these	these	DT
cord-015021-pol2qm74	3951	3	cells	cell	NNS
cord-015021-pol2qm74	3951	4	,	,	,
cord-015021-pol2qm74	3951	5	by	by	IN
cord-015021-pol2qm74	3951	6	unbalanced	unbalanced	JJ
cord-015021-pol2qm74	3951	7	production	production	NN
cord-015021-pol2qm74	3951	8	of	of	IN
cord-015021-pol2qm74	3951	9	colony	colony	NN
cord-015021-pol2qm74	3951	10	stimulating	stimulate	VBG
cord-015021-pol2qm74	3951	11	factors	factor	NNS
cord-015021-pol2qm74	3951	12	and	and	CC
cord-015021-pol2qm74	3951	13	other	other	JJ
cord-015021-pol2qm74	3951	14	mediators	mediator	NNS
cord-015021-pol2qm74	3951	15	,	,	,
cord-015021-pol2qm74	3951	16	can	can	MD
cord-015021-pol2qm74	3951	17	cause	cause	VB
cord-015021-pol2qm74	3951	18	a	a	DT
cord-015021-pol2qm74	3951	19	derangement	derangement	NN
cord-015021-pol2qm74	3951	20	of	of	IN
cord-015021-pol2qm74	3951	21	hematopoiesis	hematopoiesis	NN
cord-015021-pol2qm74	3951	22	resulting	result	VBG
cord-015021-pol2qm74	3951	23	in	in	IN
cord-015021-pol2qm74	3951	24	an	an	DT
cord-015021-pol2qm74	3951	25	abnormal	abnormal	JJ
cord-015021-pol2qm74	3951	26	production	production	NN
cord-015021-pol2qm74	3951	27	profile	profile	NN
cord-015021-pol2qm74	3951	28	of	of	IN
cord-015021-pol2qm74	3951	29	TNF	TNF	NNP
cord-015021-pol2qm74	3951	30	,	,	,
cord-015021-pol2qm74	3951	31	IL	IL	NNP
cord-015021-pol2qm74	3951	32	-	-	HYPH
cord-015021-pol2qm74	3951	33	I	I	NNP
cord-015021-pol2qm74	3951	34	,	,	,
cord-015021-pol2qm74	3951	35	and	and	CC
cord-015021-pol2qm74	3951	36	IL-6	IL-6	NNP
cord-015021-pol2qm74	3951	37	and	and	CC
cord-015021-pol2qm74	3951	38	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	3951	39	activity	activity	NN
cord-015021-pol2qm74	3951	40	of	of	IN
cord-015021-pol2qm74	3951	41	bone	bone	NN
cord-015021-pol2qm74	3951	42	marrow	marrow	NN
cord-015021-pol2qm74	3951	43	derived	derive	VBN
cord-015021-pol2qm74	3951	44	cells	cell	NNS
cord-015021-pol2qm74	3951	45	.	.	.
cord-015021-pol2qm74	3952	1	The	the	DT
cord-015021-pol2qm74	3952	2	results	result	NNS
cord-015021-pol2qm74	3952	3	of	of	IN
cord-015021-pol2qm74	3952	4	our	-PRON-	PRP$
cord-015021-pol2qm74	3952	5	studies	study	NNS
cord-015021-pol2qm74	3952	6	so	so	RB
cord-015021-pol2qm74	3952	7	far	far	RB
cord-015021-pol2qm74	3952	8	have	have	VBP
cord-015021-pol2qm74	3952	9	supported	support	VBN
cord-015021-pol2qm74	3952	10	parts	part	NNS
cord-015021-pol2qm74	3952	11	of	of	IN
cord-015021-pol2qm74	3952	12	this	this	DT
cord-015021-pol2qm74	3952	13	hypothesis	hypothesis	NN
cord-015021-pol2qm74	3952	14	.	.	.
cord-015021-pol2qm74	3953	1	IL-3	IL-3	NNP
cord-015021-pol2qm74	3953	2	and	and	CC
cord-015021-pol2qm74	3953	3	IL-3+M	IL-3+M	NNP
cord-015021-pol2qm74	3953	4	-	-	HYPH
cord-015021-pol2qm74	3953	5	CSF	csf	NN
cord-015021-pol2qm74	3953	6	treatments	treatment	NNS
cord-015021-pol2qm74	3953	7	increased	increase	VBD
cord-015021-pol2qm74	3953	8	the	the	DT
cord-015021-pol2qm74	3953	9	production	production	NN
cord-015021-pol2qm74	3953	10	of	of	IN
cord-015021-pol2qm74	3953	11	TNF	TNF	NNP
cord-015021-pol2qm74	3953	12	in	in	IN
cord-015021-pol2qm74	3953	13	burn	burn	NN
cord-015021-pol2qm74	3953	14	4	4	CD
cord-015021-pol2qm74	3953	15	day	day	NN
cord-015021-pol2qm74	3953	16	macrophages	macrophage	NNS
cord-015021-pol2qm74	3953	17	and	and	CC
cord-015021-pol2qm74	3953	18	progenitor	progenitor	NN
cord-015021-pol2qm74	3953	19	cells	cell	NNS
cord-015021-pol2qm74	3953	20	compared	compare	VBN
cord-015021-pol2qm74	3953	21	to	to	IN
cord-015021-pol2qm74	3953	22	normal	normal	JJ
cord-015021-pol2qm74	3953	23	cells	cell	NNS
cord-015021-pol2qm74	3953	24	.	.	.
cord-015021-pol2qm74	3954	1	IL-3+M	il-3+m	LS
cord-015021-pol2qm74	3954	2	-	-	:
cord-015021-pol2qm74	3954	3	CSF+IL-10	csf+il-10	NN
cord-015021-pol2qm74	3954	4	increased	increase	VBD
cord-015021-pol2qm74	3954	5	the	the	DT
cord-015021-pol2qm74	3954	6	production	production	NN
cord-015021-pol2qm74	3954	7	of	of	IN
cord-015021-pol2qm74	3954	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	3954	9	by	by	IN
cord-015021-pol2qm74	3954	10	burn	burn	NN
cord-015021-pol2qm74	3954	11	progenitor	progenitor	NN
cord-015021-pol2qm74	3954	12	cells	cell	NNS
cord-015021-pol2qm74	3954	13	compared	compare	VBN
cord-015021-pol2qm74	3954	14	to	to	IN
cord-015021-pol2qm74	3954	15	normal	normal	JJ
cord-015021-pol2qm74	3954	16	macrophagee	macrophagee	NN
cord-015021-pol2qm74	3954	17	.	.	.
cord-015021-pol2qm74	3955	1	Preliminary	preliminary	JJ
cord-015021-pol2qm74	3955	2	results	result	NNS
cord-015021-pol2qm74	3955	3	for	for	IN
cord-015021-pol2qm74	3955	4	the	the	DT
cord-015021-pol2qm74	3955	5	ratios	ratio	NNS
cord-015021-pol2qm74	3955	6	of	of	IN
cord-015021-pol2qm74	3955	7	TNF/~	TNF/~	NNP
cord-015021-pol2qm74	3955	8	actin	actin	NN
cord-015021-pol2qm74	3955	9	mRNA	mrna	NN
cord-015021-pol2qm74	3955	10	indicate	indicate	VBP
cord-015021-pol2qm74	3955	11	that	that	IN
cord-015021-pol2qm74	3955	12	IL-3+M	IL-3+M	NNP
cord-015021-pol2qm74	3955	13	-	-	HYPH
cord-015021-pol2qm74	3955	14	CSF	csf	NN
cord-015021-pol2qm74	3955	15	increased	increase	VBD
cord-015021-pol2qm74	3955	16	the	the	DT
cord-015021-pol2qm74	3955	17	mRNA	mrna	NN
cord-015021-pol2qm74	3955	18	for	for	IN
cord-015021-pol2qm74	3955	19	TNF	TNF	NNP
cord-015021-pol2qm74	3955	20	in	in	IN
cord-015021-pol2qm74	3955	21	the	the	DT
cord-015021-pol2qm74	3955	22	4-day	4-day	JJ
cord-015021-pol2qm74	3955	23	macrophages	macrophage	NNS
cord-015021-pol2qm74	3955	24	derived	derive	VBN
cord-015021-pol2qm74	3955	25	from	from	IN
cord-015021-pol2qm74	3955	26	burned	burn	VBN
cord-015021-pol2qm74	3955	27	animals	animal	NNS
cord-015021-pol2qm74	3955	28	compared	compare	VBN
cord-015021-pol2qm74	3955	29	to	to	IN
cord-015021-pol2qm74	3955	30	macrophages	macrophage	NNS
cord-015021-pol2qm74	3955	31	derived	derive	VBN
cord-015021-pol2qm74	3955	32	from	from	IN
cord-015021-pol2qm74	3955	33	normal	normal	JJ
cord-015021-pol2qm74	3955	34	animals	animal	NNS
cord-015021-pol2qm74	3955	35	.	.	.
cord-015021-pol2qm74	3956	1	Ratios	ratio	NNS
cord-015021-pol2qm74	3956	2	of	of	IN
cord-015021-pol2qm74	3956	3	IL-6/~	IL-6/~	NNP
cord-015021-pol2qm74	3956	4	actin	actin	NN
cord-015021-pol2qm74	3956	5	mRNA	mRNA	NNP
cord-015021-pol2qm74	3956	6	indicated	indicate	VBD
cord-015021-pol2qm74	3956	7	that	that	IN
cord-015021-pol2qm74	3956	8	IL-3	IL-3	NNP
cord-015021-pol2qm74	3956	9	,	,	,
cord-015021-pol2qm74	3956	10	IL-3+M	il-3+m	CD
cord-015021-pol2qm74	3956	11	-	-	HYPH
cord-015021-pol2qm74	3956	12	CSF	CSF	NNP
cord-015021-pol2qm74	3956	13	,	,	,
cord-015021-pol2qm74	3956	14	and	and	CC
cord-015021-pol2qm74	3956	15	M	M	NNP
cord-015021-pol2qm74	3956	16	-	-	HYPH
cord-015021-pol2qm74	3956	17	CSF	CSF	NNP
cord-015021-pol2qm74	3956	18	increased	increase	VBD
cord-015021-pol2qm74	3956	19	the	the	DT
cord-015021-pol2qm74	3956	20	IL-6	IL-6	NNP
cord-015021-pol2qm74	3956	21	~RNA	~RNA	NNP
cord-015021-pol2qm74	3956	22	in	in	IN
cord-015021-pol2qm74	3956	23	progenitor	progenitor	NN
cord-015021-pol2qm74	3956	24	cells	cell	NNS
cord-015021-pol2qm74	3956	25	from	from	IN
cord-015021-pol2qm74	3956	26	burn	burn	NN
cord-015021-pol2qm74	3956	27	animals	animal	NNS
cord-015021-pol2qm74	3956	28	compared	compare	VBN
cord-015021-pol2qm74	3956	29	to	to	IN
cord-015021-pol2qm74	3956	30	progenitor	progenitor	NN
cord-015021-pol2qm74	3956	31	cells	cell	NNS
cord-015021-pol2qm74	3956	32	from	from	IN
cord-015021-pol2qm74	3956	33	normal	normal	JJ
cord-015021-pol2qm74	3956	34	animals	animal	NNS
cord-015021-pol2qm74	3956	35	.	.	.
cord-015021-pol2qm74	3957	1	These	these	DT
cord-015021-pol2qm74	3957	2	preliminary	preliminary	JJ
cord-015021-pol2qm74	3957	3	results	result	NNS
cord-015021-pol2qm74	3957	4	support	support	VBP
cord-015021-pol2qm74	3957	5	our	-PRON-	PRP$
cord-015021-pol2qm74	3957	6	hypothesis	hypothesis	NN
cord-015021-pol2qm74	3957	7	that	that	IN
cord-015021-pol2qm74	3957	8	bone	bone	NN
cord-015021-pol2qm74	3957	9	marrow	marrow	NN
cord-015021-pol2qm74	3957	10	derived	derive	VBD
cord-015021-pol2qm74	3957	11	macrophages	macrophage	NNS
cord-015021-pol2qm74	3957	12	and	and	CC
cord-015021-pol2qm74	3957	13	progenitor	progenitor	NN
cord-015021-pol2qm74	3957	14	cells	cell	NNS
cord-015021-pol2qm74	3957	15	from	from	IN
cord-015021-pol2qm74	3957	16	burned	burn	VBN
cord-015021-pol2qm74	3957	17	animals	animal	NNS
cord-015021-pol2qm74	3957	18	act	act	VBP
cord-015021-pol2qm74	3957	19	differently	differently	RB
cord-015021-pol2qm74	3957	20	compared	compare	VBN
cord-015021-pol2qm74	3957	21	to	to	IN
cord-015021-pol2qm74	3957	22	cells	cell	NNS
cord-015021-pol2qm74	3957	23	from	from	IN
cord-015021-pol2qm74	3957	24	unburned	unburned	JJ
cord-015021-pol2qm74	3957	25	animals	animal	NNS
cord-015021-pol2qm74	3957	26	regarding	regard	VBG
cord-015021-pol2qm74	3957	27	the	the	DT
cord-015021-pol2qm74	3957	28	production	production	NN
cord-015021-pol2qm74	3957	29	of	of	IN
cord-015021-pol2qm74	3957	30	inflanunatory	inflanunatory	NNP
cord-015021-pol2qm74	3957	31	cytokines	cytokine	NNS
cord-015021-pol2qm74	3957	32	.	.	.
cord-015021-pol2qm74	3958	1	More	more	RBR
cord-015021-pol2qm74	3958	2	specifically	specifically	RB
cord-015021-pol2qm74	3958	3	,	,	,
cord-015021-pol2qm74	3958	4	the	the	DT
cord-015021-pol2qm74	3958	5	results	result	NNS
cord-015021-pol2qm74	3958	6	suggest	suggest	VBP
cord-015021-pol2qm74	3958	7	that	that	IN
cord-015021-pol2qm74	3958	8	the	the	DT
cord-015021-pol2qm74	3958	9	different	different	JJ
cord-015021-pol2qm74	3958	10	cell	cell	NN
cord-015021-pol2qm74	3958	11	types	type	NNS
cord-015021-pol2qm74	3958	12	are	be	VBP
cord-015021-pol2qm74	3958	13	regulated	regulate	VBN
cord-015021-pol2qm74	3958	14	in	in	IN
cord-015021-pol2qm74	3958	15	different	different	JJ
cord-015021-pol2qm74	3958	16	ways	way	NNS
cord-015021-pol2qm74	3958	17	by	by	IN
cord-015021-pol2qm74	3958	18	cytokines	cytokine	NNS
cord-015021-pol2qm74	3958	19	,	,	,
cord-015021-pol2qm74	3958	20	and	and	CC
cord-015021-pol2qm74	3958	21	cells	cell	NNS
cord-015021-pol2qm74	3958	22	from	from	IN
cord-015021-pol2qm74	3958	23	burned	burn	VBN
cord-015021-pol2qm74	3958	24	animals	animal	NNS
cord-015021-pol2qm74	3958	25	are	be	VBP
cord-015021-pol2qm74	3958	26	regulated	regulate	VBN
cord-015021-pol2qm74	3958	27	differently	differently	RB
cord-015021-pol2qm74	3958	28	than	than	IN
cord-015021-pol2qm74	3958	29	cells	cell	NNS
cord-015021-pol2qm74	3958	30	from	from	IN
cord-015021-pol2qm74	3958	31	unburned	unburned	JJ
cord-015021-pol2qm74	3958	32	animals	animal	NNS
cord-015021-pol2qm74	3958	33	.	.	.
cord-015021-pol2qm74	3959	1	It	-PRON-	PRP
cord-015021-pol2qm74	3960	1	i,~	i,~	RB
cord-015021-pol2qm74	3960	2	to	to	IN
cord-015021-pol2qm74	3961	1	~ssume	~ssume	NNP
cord-015021-pol2qm74	3962	1	that	that	IN
cord-015021-pol2qm74	3962	2	the	the	DT
cord-015021-pol2qm74	3962	3	translneatinn	translneatinn	NN
cord-015021-pol2qm74	3962	4	is	be	VBZ
cord-015021-pol2qm74	3962	5	due	due	JJ
cord-015021-pol2qm74	3962	6	to	to	IN
cord-015021-pol2qm74	3962	7	a	a	DT
cord-015021-pol2qm74	3962	8	Ixx	Ixx	NNP
cord-015021-pol2qm74	3962	9	~	~	NNP
cord-015021-pol2qm74	3962	10	H	H	NNP
cord-015021-pol2qm74	3962	11	,	,	,
cord-015021-pol2qm74	3962	12	v	v	LS
cord-015021-pol2qm74	3962	13	functioning	function	VBG
cord-015021-pol2qm74	3962	14	~astroiutestlnal	~astroiutestlnal	CD
cord-015021-pol2qm74	3962	15	surface	surface	NN
cord-015021-pol2qm74	3962	16	pro|ection	pro|ection	NN
cord-015021-pol2qm74	3962	17	system	system	NN
cord-015021-pol2qm74	3962	18	,	,	,
cord-015021-pol2qm74	3962	19	which	which	WDT
cord-015021-pol2qm74	3962	20	leads	lead	VBZ
cord-015021-pol2qm74	3962	21	to	to	IN
cord-015021-pol2qm74	3962	22	an	an	DT
cord-015021-pol2qm74	3962	23	unacceptably	unacceptably	RB
cord-015021-pol2qm74	3962	24	high	high	JJ
cord-015021-pol2qm74	3962	25	load	load	NN
cord-015021-pol2qm74	3962	26	¢ln	¢ln	XX
cord-015021-pol2qm74	3962	27	the	the	DT
cord-015021-pol2qm74	3962	28	Imrsunc	Imrsunc	NNP
cord-015021-pol2qm74	3962	29	dcfcncc	dcfcncc	NN
cord-015021-pol2qm74	3962	30	system	system	NN
cord-015021-pol2qm74	3962	31	,	,	,
cord-015021-pol2qm74	3962	32	partlcul	partlcul	NNP
cord-015021-pol2qm74	3963	1	~ly	~ly	NNP
cord-015021-pol2qm74	3963	2	the	the	DT
cord-015021-pol2qm74	3963	3	local	local	JJ
cord-015021-pol2qm74	3963	4	system	system	NN
cord-015021-pol2qm74	3963	5	in	in	IN
cord-015021-pol2qm74	3963	6	the	the	DT
cord-015021-pol2qm74	3963	7	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	3963	8	wall	wall	NN
cord-015021-pol2qm74	3963	9	,	,	,
cord-015021-pol2qm74	3963	10	leading	lead	VBG
cord-015021-pol2qm74	3963	11	tu	tu	NNP
cord-015021-pol2qm74	3963	12	exh	exh	NNP
cord-015021-pol2qm74	3963	13	~	~	NNP
cord-015021-pol2qm74	3963	14	ustiou	ustiou	NNP
cord-015021-pol2qm74	3963	15	Of	of	IN
cord-015021-pol2qm74	3963	16	Ihi~	Ihi~	NNP
cord-015021-pol2qm74	3963	17	System	System	NNP
cord-015021-pol2qm74	3963	18	.	.	.
cord-015021-pol2qm74	3964	1	Tlae	Tlae	NNP
cord-015021-pol2qm74	3964	2	g&~lrointesliual	g&~lrointesliual	JJ
cord-015021-pol2qm74	3964	3	I]'ac	i]'ac	NN
cord-015021-pol2qm74	3965	1	(	(	-LRB-
cord-015021-pol2qm74	3965	2	can	can	MD
cord-015021-pol2qm74	3965	3	be	be	VB
cord-015021-pol2qm74	3965	4	regal'deal	regal'deal	NNP
cord-015021-pol2qm74	3965	5	a.s	a.s	NNP
cord-015021-pol2qm74	3966	1	a	a	DT
cord-015021-pol2qm74	3966	2	t~2servoJf	t~2servoJf	NNP
cord-015021-pol2qm74	3966	3	of	of	IN
cord-015021-pol2qm74	3966	4	appr	appr	NNP
cord-015021-pol2qm74	3966	5	200	200	CD
cord-015021-pol2qm74	3966	6	m	m	NN
cord-015021-pol2qm74	3966	7	~	~	NFP
cord-015021-pol2qm74	3966	8	separating	separate	VBG
cord-015021-pol2qm74	3966	9	10	10	CD
cord-015021-pol2qm74	3966	10	I~	I~	NNP
cord-015021-pol2qm74	3966	11	eucayotic	eucayotic	JJ
cord-015021-pol2qm74	3966	12	ceils	ceil	NNS
cord-015021-pol2qm74	3966	13	of	of	IN
cord-015021-pol2qm74	3966	14	the	the	DT
cord-015021-pol2qm74	3966	15	hosl	hosl	NNP
cord-015021-pol2qm74	3966	16	ttom	ttom	NN
cord-015021-pol2qm74	3966	17	l0	l0	NNP
cord-015021-pol2qm74	3966	18	~4	~4	CD
cord-015021-pol2qm74	3966	19	bacterial	bacterial	JJ
cord-015021-pol2qm74	3966	20	culls	cull	NNS
cord-015021-pol2qm74	3966	21	.	.	.
cord-015021-pol2qm74	3967	1	In	in	IN
cord-015021-pol2qm74	3967	2	the	the	DT
cord-015021-pol2qm74	3967	3	human	human	JJ
cord-015021-pol2qm74	3967	4	body	body	NN
cord-015021-pol2qm74	3967	5	the	the	DT
cord-015021-pol2qm74	3967	6	the	the	DT
cord-015021-pol2qm74	3967	7	myriad	myriad	NN
cord-015021-pol2qm74	3967	8	of	of	IN
cord-015021-pol2qm74	3967	9	cndngan¢nts	cndngan¢nts	NNP
cord-015021-pol2qm74	3967	10	micrix)rganistns	micrix)rganistns	NNP
cord-015021-pol2qm74	3967	11	,	,	,
cord-015021-pol2qm74	3967	12	exogenous	exogenous	JJ
cord-015021-pol2qm74	3967	13	itl,~ttdittg	itl,~ttdittg	NNP
cord-015021-pol2qm74	3967	14	micro	micro	FW
cord-015021-pol2qm74	3967	15	~	~	CD
cord-015021-pol2qm74	3967	16	ganisms	ganisms	NNP
cord-015021-pol2qm74	3967	17	altd	altd	NNP
cord-015021-pol2qm74	3967	18	taxies	taxi	NNS
cord-015021-pol2qm74	3968	1	m-'e	m-'e	NNP
cord-015021-pol2qm74	3968	2	sepia"areal	sepia"areal	''
cord-015021-pol2qm74	3969	1	li'otll	li'otll	NNP
cord-015021-pol2qm74	3969	2	Lhe	Lhe	NNP
cord-015021-pol2qm74	3969	3	rest	rest	NN
cord-015021-pol2qm74	3969	4	of	of	IN
cord-015021-pol2qm74	3969	5	the	the	DT
cord-015021-pol2qm74	3969	6	body	body	NN
cord-015021-pol2qm74	3969	7	by	by	IN
cord-015021-pol2qm74	3969	8	a	a	DT
cord-015021-pol2qm74	3969	9	simple	simple	JJ
cord-015021-pol2qm74	3969	10	epithclhd	epithclhd	NN
cord-015021-pol2qm74	3969	11	layer	layer	NN
cord-015021-pol2qm74	3969	12	.	.	.
cord-015021-pol2qm74	3970	1	The	the	DT
cord-015021-pol2qm74	3970	2	barrier	barrier	NN
cord-015021-pol2qm74	3970	3	function	function	NN
cord-015021-pol2qm74	3970	4	is	be	VBZ
cord-015021-pol2qm74	3970	5	heavily	heavily	RB
cord-015021-pol2qm74	3970	6	tlcpcnding	tlcpcnde	VBG
cord-015021-pol2qm74	3970	7	tm	tm	NN
cord-015021-pol2qm74	3970	8	=	=	NNP
cord-015021-pol2qm74	3970	9	~	~	NFP
cord-015021-pol2qm74	3970	10	proleclive	proleclive	NNP
cord-015021-pol2qm74	3970	11	layer	layer	NN
cord-015021-pol2qm74	3970	12	cmtsisting	cmtsiste	VBG
cord-015021-pol2qm74	3970	13	ie	ie	NNP
cord-015021-pol2qm74	3970	14	.	.	.
cord-015021-pol2qm74	3971	1	surl~:Emts	surl~:emts	RB
cord-015021-pol2qm74	3971	2	,	,	,
cord-015021-pol2qm74	3971	3	nluCltS	nluCltS	NNP
cord-015021-pol2qm74	3971	4	,	,	,
cord-015021-pol2qm74	3971	5	probiotic	probiotic	JJ
cord-015021-pol2qm74	3971	6	bacteria	bacteria	NNS
cord-015021-pol2qm74	3971	7	,	,	,
cord-015021-pol2qm74	3971	8	and	and	CC
cord-015021-pol2qm74	3971	9	,	,	,
cord-015021-pol2qm74	3971	10	~ub	~ub	ADD
cord-015021-pol2qm74	3972	1	~tances	~tance	NNS
cord-015021-pol2qm74	3972	2	with	with	IN
cord-015021-pol2qm74	3972	3	strong	strong	JJ
cord-015021-pol2qm74	3972	4	antioxid	antioxid	NN
cord-015021-pol2qm74	3972	5	~	~	NFP
cord-015021-pol2qm74	3972	6	lt	lt	NNP
cord-015021-pol2qm74	3972	7	,	,	,
cord-015021-pol2qm74	3972	8	antipfotease	antipfotease	NNP
cord-015021-pol2qm74	3972	9	al	al	NNP
cord-015021-pol2qm74	3973	1	~d	~d	NFP
cord-015021-pol2qm74	3973	2	other	other	JJ
cord-015021-pol2qm74	3973	3	i	i	NNP
cord-015021-pol2qm74	3973	4	~	~	CD
cord-015021-pol2qm74	3973	5	rotective	rotective	NNP
cord-015021-pol2qm74	3973	6	eft'ecru	eft'ecru	NNP
cord-015021-pol2qm74	3973	7	,	,	,
cord-015021-pol2qm74	3973	8	The	the	DT
cord-015021-pol2qm74	3973	9	surfaet	surfaet	NN
cord-015021-pol2qm74	3974	1	~ml	~ml	NFP
cord-015021-pol2qm74	3974	2	htycr	htycr	NNP
cord-015021-pol2qm74	3974	3	consists	consist	VBZ
cord-015021-pol2qm74	3974	4	at	at	IN
cord-015021-pol2qm74	3974	5	tile	tile	NNP
cord-015021-pol2qm74	3974	6	besl	besl	NNP
cord-015021-pol2qm74	3974	7	if1	if1	NNP
cord-015021-pol2qm74	3975	1	I	-PRON-	PRP
cord-015021-pol2qm74	3975	2	(	(	-LRB-
cord-015021-pol2qm74	3975	3	.	.	.
cord-015021-pol2qm74	3975	4	)	)	-RRB-
cord-015021-pol2qm74	3976	1	bimolecular	bimolecular	NNP
cord-015021-pol2qm74	3976	2	layers	layer	NNS
cord-015021-pol2qm74	3976	3	,	,	,
cord-015021-pol2qm74	3976	4	fl	fl	NNP
cord-015021-pol2qm74	3976	5	is	be	VBZ
cord-015021-pol2qm74	3976	6	thus	thus	RB
cord-015021-pol2qm74	3976	7	very	very	RB
cord-015021-pol2qm74	3977	1	Iltil~	iltil~	XX
cord-015021-pol2qm74	3978	1	,	,	,
cord-015021-pol2qm74	3978	2	The	the	DT
cord-015021-pol2qm74	3978	3	epilhelial	epilhelial	JJ
cord-015021-pol2qm74	3978	4	layer	layer	NN
cord-015021-pol2qm74	3978	5	is	be	VBZ
cord-015021-pol2qm74	3978	6	renewed	renew	VBN
cord-015021-pol2qm74	3978	7	every	every	DT
cord-015021-pol2qm74	3978	8	24	24	CD
cord-015021-pol2qm74	3978	9	hours	hour	NNS
cord-015021-pol2qm74	3978	10	,	,	,
cord-015021-pol2qm74	3978	11	and	and	CC
cord-015021-pol2qm74	3978	12	tile	tile	NN
cord-015021-pol2qm74	3978	13	tanuwer	tanuwer	NN
cord-015021-pol2qm74	3978	14	of	of	IN
cord-015021-pol2qm74	3978	15	the	the	DT
cord-015021-pol2qm74	3978	16	mucus	mucus	NN
cord-015021-pol2qm74	3978	17	is	be	VBZ
cord-015021-pol2qm74	3978	18	~so	~so	NNP
cord-015021-pol2qm74	3978	19	fa,~t	fa,~t	NNP
cord-015021-pol2qm74	3978	20	,	,	,
cord-015021-pol2qm74	3978	21	All	all	DT
cord-015021-pol2qm74	3978	22	attDphy	attDphy	NFP
cord-015021-pol2qm74	3978	23	of	of	IN
cord-015021-pol2qm74	3978	24	die	die	VBP
cord-015021-pol2qm74	3978	25	epithelial	epithelial	JJ
cord-015021-pol2qm74	3978	26	layei	layei	NN
cord-015021-pol2qm74	3978	27	induced	induce	VBN
cord-015021-pol2qm74	3978	28	by	by	IN
cord-015021-pol2qm74	3978	29	g&sttointestinal	g&sttointestinal	NNP
cord-015021-pol2qm74	3978	30	st~'vation	st~'vation	NNP
cord-015021-pol2qm74	3978	31	does	do	VBZ
cord-015021-pol2qm74	3978	32	also	also	RB
cord-015021-pol2qm74	3978	33	include	include	VB
cord-015021-pol2qm74	3978	34	the	the	DT
cord-015021-pol2qm74	3978	35	mu	mu	NNS
cord-015021-pol2qm74	3978	36	~	~	CD
cord-015021-pol2qm74	3978	37	usprndocing	usprndocing	NN
cord-015021-pol2qm74	3978	38	cells	cell	NNS
cord-015021-pol2qm74	3978	39	,	,	,
cord-015021-pol2qm74	3978	40	Gnhlet	Gnhlet	NNP
cord-015021-pol2qm74	3978	41	cells	cell	NNS
cord-015021-pol2qm74	3978	42	,	,	,
cord-015021-pol2qm74	3978	43	which	which	WDT
cord-015021-pol2qm74	3978	44	leaduhg	leaduhg	NNP
cord-015021-pol2qm74	3978	45	lu	lu	NNP
cord-015021-pol2qm74	3978	46	slmnage	slmnage	NNP
cord-015021-pol2qm74	3979	1	aad	aad	NNP
cord-015021-pol2qm74	3979	2	luwer	luwer	NNP
cord-015021-pol2qm74	3979	3	quality	quality	NN
cord-015021-pol2qm74	3979	4	of	of	IN
cord-015021-pol2qm74	3979	5	GI	GI	NNP
cord-015021-pol2qm74	3979	6	mucus	mucus	NN
cord-015021-pol2qm74	3979	7	,	,	,
cord-015021-pol2qm74	3979	8	altered	alter	VBN
cord-015021-pol2qm74	3979	9	viscoelas	viscoelas	NNP
cord-015021-pol2qm74	3979	10	,	,	,
cord-015021-pol2qm74	3979	11	Jc	Jc	NNP
cord-015021-pol2qm74	3979	12	properties	property	NNS
cord-015021-pol2qm74	3979	13	and	and	CC
cord-015021-pol2qm74	3979	14	reduced	reduce	VBN
cord-015021-pol2qm74	3979	15	protection	protection	NN
cord-015021-pol2qm74	3979	16	,	,	,
cord-015021-pol2qm74	3979	17	]	]	-RRB-
cord-015021-pol2qm74	3980	1	~'obioiic	~'obioiic	NNP
cord-015021-pol2qm74	3980	2	bactcrla	bactcrla	NNP
cord-015021-pol2qm74	3980	3	keeps	keep	VBZ
cord-015021-pol2qm74	3980	4	the	the	DT
cord-015021-pol2qm74	3980	5	PPM	PPM	NNP
cord-015021-pol2qm74	3980	6	's	's	POS
cord-015021-pol2qm74	3980	7	low	low	JJ
cord-015021-pol2qm74	3980	8	,	,	,
cord-015021-pol2qm74	3980	9	produce	produce	VB
cord-015021-pol2qm74	3980	10	nutrients	nutrient	NNS
cord-015021-pol2qm74	3980	11	for	for	IN
cord-015021-pol2qm74	3980	12	the	the	DT
cord-015021-pol2qm74	3980	13	intestinal	intestinal	JJ
cord-015021-pol2qm74	3980	14	mllcosa	mllcosa	NN
cord-015021-pol2qm74	3980	15	,	,	,
cord-015021-pol2qm74	3980	16	eliminates	eliminate	VBZ
cord-015021-pol2qm74	3980	17	tuxia~	tuxia~	NNP
cord-015021-pol2qm74	3980	18	and	and	CC
cord-015021-pol2qm74	3980	19	stimulates	stimulate	VBZ
cord-015021-pol2qm74	3980	20	the	the	DT
cord-015021-pol2qm74	3980	21	local	local	JJ
cord-015021-pol2qm74	3980	22	immune	immune	JJ
cord-015021-pol2qm74	3980	23	system	system	NN
cord-015021-pol2qm74	3980	24	,	,	,
cord-015021-pol2qm74	3980	25	The	the	DT
cord-015021-pol2qm74	3980	26	Gl	Gl	NNP
cord-015021-pol2qm74	3980	27	surface	surface	NN
cord-015021-pol2qm74	3980	28	is	be	VBZ
cord-015021-pol2qm74	3980	29	conslanlly	conslanlly	RB
cord-015021-pol2qm74	3980	30	under	under	IN
cord-015021-pol2qm74	3980	31	hc	hc	NNP
cord-015021-pol2qm74	3980	32	wv	wv	NNP
cord-015021-pol2qm74	3980	33	wearing	wear	VBG
cord-015021-pol2qm74	3980	34	by	by	IN
cord-015021-pol2qm74	3980	35	ingested	ingested	JJ
cord-015021-pol2qm74	3980	36	bacteria	bacteria	NNS
cord-015021-pol2qm74	3980	37	and	and	CC
cord-015021-pol2qm74	3980	38	their	-PRON-	PRP$
cord-015021-pol2qm74	3980	39	enzymes	enzyme	NNS
cord-015021-pol2qm74	3980	40	,	,	,
cord-015021-pol2qm74	3980	41	ingested	ingest	VBN
cord-015021-pol2qm74	3980	42	substaucas	substaucas	NNP
cord-015021-pol2qm74	3980	43	,	,	,
cord-015021-pol2qm74	3981	1	chefftie,'ds	chefftie,'d	NNS
cord-015021-pol2qm74	3981	2	at	at	IN
cord-015021-pol2qm74	3981	3	~	~	NFP
cord-015021-pol2qm74	3981	4	d	d	LS
cord-015021-pol2qm74	3981	5	toxins	toxin	NNS
cord-015021-pol2qm74	3981	6	.	.	.
cord-015021-pol2qm74	3981	7	'	'	''
cord-015021-pol2qm74	3982	1	ll~	ll~	NNP
cord-015021-pol2qm74	3983	1	e	e	LS
cord-015021-pol2qm74	3983	2	N~	N~	NNP
cord-015021-pol2qm74	3984	1	tective	tective	NNP
cord-015021-pol2qm74	3984	2	flora	flora	NNP
cord-015021-pol2qm74	3984	3	is	be	VBZ
cord-015021-pol2qm74	3984	4	reduCed	reduced	NN
cord-015021-pol2qm74	3984	5	in	in	IN
cord-015021-pol2qm74	3984	6	disease	disease	NN
cord-015021-pol2qm74	3984	7	,	,	,
cord-015021-pol2qm74	3984	8	by	by	IN
cord-015021-pol2qm74	3984	9	stress	stress	NN
cord-015021-pol2qm74	3984	10	and	and	CC
cord-015021-pol2qm74	3984	11	by	by	IN
cord-015021-pol2qm74	3984	12	cm'clcss	cm'clcss	CD
cord-015021-pol2qm74	3984	13	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	3984	14	therapy	therapy	NN
cord-015021-pol2qm74	3984	15	.	.	.
cord-015021-pol2qm74	3985	1	Wc	Wc	NNS
cord-015021-pol2qm74	3985	2	have	have	VBP
cord-015021-pol2qm74	3985	3	made	make	VBN
cord-015021-pol2qm74	3985	4	attempts	attempt	NNS
cord-015021-pol2qm74	3985	5	tn	tn	NNP
cord-015021-pol2qm74	3985	6	recondition	recondition	VB
cord-015021-pol2qm74	3985	7	the	the	DT
cord-015021-pol2qm74	3985	8	I,,.astroiniesli!l	I,,.astroiniesli!l	NNP
cord-015021-pol2qm74	3985	9	~	~	NNP
cord-015021-pol2qm74	3985	10	d	d	NN
cord-015021-pol2qm74	3985	11	.	.	.
cord-015021-pol2qm74	3986	1	tnucoSa	tnucoSa	NNP
cord-015021-pol2qm74	3986	2	by	by	IN
cord-015021-pol2qm74	3986	3	rcstlpply	rcstlpply	NNP
cord-015021-pol2qm74	3986	4	of	of	IN
cord-015021-pol2qm74	3986	5	surfactants	surfactant	NNS
cord-015021-pol2qm74	3986	6	or	or	CC
cord-015021-pol2qm74	3986	7	sttrfactanfliko	sttrfactanfliko	NN
cord-015021-pol2qm74	3986	8	glyc	glyc	NNP
cord-015021-pol2qm74	3987	1	~lipids	~lipids	NNP
cord-015021-pol2qm74	3987	2	,	,	,
cord-015021-pol2qm74	3987	3	gels	gel	NNS
cord-015021-pol2qm74	3987	4	with	with	IN
cord-015021-pol2qm74	3987	5	pseudomuein	pseudomuein	NNP
cord-015021-pol2qm74	3987	6	[	[	-LRB-
cord-015021-pol2qm74	3987	7	until.oil	until.oil	ADD
cord-015021-pol2qm74	3987	8	,	,	,
cord-015021-pol2qm74	3987	9	and	and	CC
cord-015021-pol2qm74	3987	10	probiotl¢	probiotl¢	NNP
cord-015021-pol2qm74	3987	11	laetobaeilli	laetobaeilli	NNP
cord-015021-pol2qm74	3987	12	.	.	.
cord-015021-pol2qm74	3988	1	By	by	IN
cord-015021-pol2qm74	3988	2	supply	supply	NN
cord-015021-pol2qm74	3988	3	of	of	IN
cord-015021-pol2qm74	3988	4	glycolipids	glycolipid	NNS
cord-015021-pol2qm74	3988	5	we	-PRON-	PRP
cord-015021-pol2qm74	3988	6	have	have	VBP
cord-015021-pol2qm74	3988	7	bt	bt	NNP
cord-015021-pol2qm74	3988	8	:	:	:
cord-015021-pol2qm74	3988	9	cn	cn	NNP
cord-015021-pol2qm74	3988	10	able	able	JJ
cord-015021-pol2qm74	3988	11	m	m	TO
cord-015021-pol2qm74	3988	12	prevent	prevent	VB
cord-015021-pol2qm74	3988	13	and	and	CC
cord-015021-pol2qm74	3988	14	heal	heal	VB
cord-015021-pol2qm74	3988	15	intlammatory	intlammatory	JJ
cord-015021-pol2qm74	3988	16	and	and	CC
cord-015021-pol2qm74	3988	17	tlleerallve	tlleerallve	NN
cord-015021-pol2qm74	3988	18	injuries	injury	NNS
cord-015021-pol2qm74	3988	19	(	(	-LRB-
cord-015021-pol2qm74	3988	20	and	and	CC
cord-015021-pol2qm74	3988	21	Io	Io	NNP
cord-015021-pol2qm74	3988	22	p)'cveut	p)'cveut	CD
cord-015021-pol2qm74	3988	23	microbe	microbe	NN
cord-015021-pol2qm74	3988	24	transhteatkln	transhteatkln	NN
cord-015021-pol2qm74	3988	25	)	)	-RRB-
cord-015021-pol2qm74	3988	26	in	in	IN
cord-015021-pol2qm74	3988	27	uppe~	uppe~	NNP
cord-015021-pol2qm74	3988	28	'	'	''
cord-015021-pol2qm74	3988	29	and	and	CC
cord-015021-pol2qm74	3988	30	lower	low	JJR
cord-015021-pol2qm74	3988	31	(	(	-LRB-
cord-015021-pol2qm74	3988	32	.31	.31	.
cord-015021-pol2qm74	3989	1	u'acl	u'acl	UH
cord-015021-pol2qm74	3989	2	,	,	,
cord-015021-pol2qm74	3990	1	This	this	DT
cord-015021-pol2qm74	3990	2	c	c	NN
cord-015021-pol2qm74	3991	1	~al	~al	NNP
cord-015021-pol2qm74	3991	2	be	be	VB
cord-015021-pol2qm74	3991	3	fu~'ther	fu~'ther	CD
cord-015021-pol2qm74	3991	4	augmentented	augmentente	VBN
cord-015021-pol2qm74	3991	5	by	by	IN
cord-015021-pol2qm74	3991	6	shnultaueos	shnultaueos	NNP
cord-015021-pol2qm74	3991	7	supply	supply	NNP
cord-015021-pol2qm74	3992	1	el	el	NNP
cord-015021-pol2qm74	3992	2	'	'	``
cord-015021-pol2qm74	3992	3	a	a	DT
cord-015021-pol2qm74	3992	4	p.~uedomucin	p.~uedomucin	NNS
cord-015021-pol2qm74	3992	5	,	,	,
cord-015021-pol2qm74	3992	6	likc	likc	NNP
cord-015021-pol2qm74	3992	7	gel	gel	NN
cord-015021-pol2qm74	3992	8	like	like	IN
cord-015021-pol2qm74	3992	9	pectin	pectin	NN
cord-015021-pol2qm74	3992	10	.	.	.
cord-015021-pol2qm74	3993	1	(	(	-LRB-
cord-015021-pol2qm74	3993	2	)	)	-RRB-
cord-015021-pol2qm74	3993	3	at	at	IN
cord-015021-pol2qm74	3993	4	contain~	contain~	NNP
cord-015021-pol2qm74	3993	5	one	one	CD
cord-015021-pol2qm74	3993	6	hundred	hundred	CD
cord-015021-pol2qm74	3993	7	times	time	NNS
cord-015021-pol2qm74	3993	8	more	more	JJR
cord-015021-pol2qm74	3993	9	ot	ot	NN
cord-015021-pol2qm74	3993	10	membrane	membrane	NN
cord-015021-pol2qm74	3993	11	lipid$	lipid$	NNS
cord-015021-pol2qm74	3993	12	th	th	XX
cord-015021-pol2qm74	3993	13	~	~	NFP
cord-015021-pol2qm74	3993	14	a	a	DT
cord-015021-pol2qm74	3993	15	=	=	SYM
cord-015021-pol2qm74	3993	16	nay	nay	NN
cord-015021-pol2qm74	3993	17	other	other	JJ
cord-015021-pol2qm74	3993	18	food	food	NN
cord-015021-pol2qm74	3993	19	,	,	,
cord-015021-pol2qm74	3993	20	much	much	JJ
cord-015021-pol2qm74	3993	21	of	of	IN
cord-015021-pol2qm74	3993	22	fiber	fiber	NN
cord-015021-pol2qm74	3993	23	,	,	,
cord-015021-pol2qm74	3993	24	~spceially	~spceially	NNP
cord-015021-pol2qm74	3993	25	watcrsnlnhlc	watcrsnlnhlc	NNP
cord-015021-pol2qm74	3993	26	betaglucaal~	betaglucaal~	NNP
cord-015021-pol2qm74	3993	27	,	,	,
cord-015021-pol2qm74	3993	28	at	at	IN
cord-015021-pol2qm74	3993	29	~	~	NFP
cord-015021-pol2qm74	3993	30	d	d	NN
cord-015021-pol2qm74	3993	31	has	have	VBZ
cord-015021-pol2qm74	3993	32	an	an	DT
cord-015021-pol2qm74	3993	33	close	close	NN
cord-015021-pol2qm74	3993	34	to	to	IN
cord-015021-pol2qm74	3993	35	ideal	ideal	JJ
cord-015021-pol2qm74	3993	36	amino	amino	NN
cord-015021-pol2qm74	3993	37	acid	acid	NN
cord-015021-pol2qm74	3993	38	cornpo	cornpo	NNP
cord-015021-pol2qm74	3993	39	~	~	CD
cord-015021-pol2qm74	3993	40	ition	ition	NNP
cord-015021-pol2qm74	3993	41	,	,	,
cord-015021-pol2qm74	3993	42	<	<	XX
cord-015021-pol2qm74	3993	43	'	'	POS
cord-015021-pol2qm74	3993	44	)	)	-RRB-
cord-015021-pol2qm74	3993	45	at	at	IN
cord-015021-pol2qm74	3993	46	,	,	,
cord-015021-pol2qm74	3993	47	termented	termente	VBN
cord-015021-pol2qm74	3993	48	by	by	IN
cord-015021-pol2qm74	3993	49	species	species	NN
cord-015021-pol2qm74	3993	50	-	-	HYPH
cord-015021-pol2qm74	3993	51	specific	specific	JJ
cord-015021-pol2qm74	3993	52	lactobacilli	lactobacilli	NN
cord-015021-pol2qm74	3993	53	,	,	,
cord-015021-pol2qm74	3993	54	has	have	VBZ
cord-015021-pol2qm74	3993	55	a	a	DT
cord-015021-pol2qm74	3993	56	strOl~	strol~	NN
cord-015021-pol2qm74	3993	57	ability	ability	NN
cord-015021-pol2qm74	3993	58	to	to	TO
cord-015021-pol2qm74	3993	59	prevent	prevent	VB
cord-015021-pol2qm74	3993	60	local	local	JJ
cord-015021-pol2qm74	3993	61	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3993	62	and	and	CC
cord-015021-pol2qm74	3993	63	ulcerative	ulcerative	JJ
cord-015021-pol2qm74	3993	64	chunges	chunge	NNS
cord-015021-pol2qm74	3993	65	,	,	,
cord-015021-pol2qm74	3993	66	transh)cadnn	transh)cadnn	NNP
cord-015021-pol2qm74	3993	67	and	and	CC
cord-015021-pol2qm74	3993	68	sepsis	sepsis	NN
cord-015021-pol2qm74	3993	69	in	in	IN
cord-015021-pol2qm74	3993	70	experimeut	experimeut	NNP
cord-015021-pol2qm74	3993	71	~	~	NFP
cord-015021-pol2qm74	3993	72	d	d	NN
cord-015021-pol2qm74	3993	73	attimals	attimal	NNS
cord-015021-pol2qm74	3993	74	mid	mid	JJ
cord-015021-pol2qm74	3993	75	to	to	IN
cord-015021-pol2qm74	3993	76	pl	pl	XX
cord-015021-pol2qm74	3994	1	~ven~	~ven~	NNP
cord-015021-pol2qm74	3994	2	revert	revert	VB
cord-015021-pol2qm74	3994	3	MOF	MOF	NNP
cord-015021-pol2qm74	3994	4	in	in	IN
cord-015021-pol2qm74	3994	5	ba	ba	NNP
cord-015021-pol2qm74	3994	6	,	,	,
cord-015021-pol2qm74	3994	7	nan.~.lt	nan.~.lt	NNP
cord-015021-pol2qm74	3994	8	seems	seem	VBZ
cord-015021-pol2qm74	3994	9	us	-PRON-	PRP
cord-015021-pol2qm74	3994	10	,	,	,
cord-015021-pol2qm74	3994	11	that	that	IN
cord-015021-pol2qm74	3994	12	it	-PRON-	PRP
cord-015021-pol2qm74	3994	13	the	the	DT
cord-015021-pol2qm74	3994	14	mucos	mucos	NNP
cord-015021-pol2qm74	3994	15	~	~	NFP
cord-015021-pol2qm74	3994	16	lnucus	lnucus	NNP
cord-015021-pol2qm74	3994	17	/	/	SYM
cord-015021-pol2qm74	3994	18	probiotic	probiotic	JJ
cord-015021-pol2qm74	3994	19	bacterial	bacterial	JJ
cord-015021-pol2qm74	3994	20	filnclinns	filnclinns	NN
cord-015021-pol2qm74	3994	21	cat'=	cat'=	NNP
cord-015021-pol2qm74	3994	22	1	1	CD
cord-015021-pol2qm74	3994	23	%	%	NN
cord-015021-pol2qm74	3994	24	'	'	''
cord-015021-pol2qm74	3994	25	restated	restate	VBN
cord-015021-pol2qm74	3994	26	by	by	IN
cord-015021-pol2qm74	3994	27	mucosa	mucosa	JJ
cord-015021-pol2qm74	3994	28	reconditioning	reconditioning	NN
cord-015021-pol2qm74	3994	29	,	,	,
cord-015021-pol2qm74	3994	30	even	even	RB
cord-015021-pol2qm74	3994	31	in	in	IN
cord-015021-pol2qm74	3994	32	severely	severely	RB
cord-015021-pol2qm74	3994	33	sick	sick	JJ
cord-015021-pol2qm74	3994	34	iudividuals	iudividual	NNS
cord-015021-pol2qm74	3994	35	)	)	-RRB-
cord-015021-pol2qm74	3995	1	the	the	DT
cord-015021-pol2qm74	3995	2	hx:~d	hx:~d	NNPS
cord-015021-pol2qm74	3995	3	iuuuuue	iuuuuue	NNP
cord-015021-pol2qm74	3995	4	~y,~teme	~y,~teme	NNP
cord-015021-pol2qm74	3995	5	will	will	MD
cord-015021-pol2qm74	3995	6	be	be	VB
cord-015021-pol2qm74	3995	7	capable	capable	JJ
cord-015021-pol2qm74	3995	8	tu	tu	NNP
cord-015021-pol2qm74	3995	9	pr~)tec	pr~)tec	NNP
cord-015021-pol2qm74	3995	10	!	!	.
cord-015021-pol2qm74	3996	1	the	the	DT
cord-015021-pol2qm74	3996	2	Ix	Ix	NNP
cord-015021-pol2qm74	3996	3	~	~	NNP
cord-015021-pol2qm74	3996	4	y	y	NNP
cord-015021-pol2qm74	3996	5	ag~	ag~	NN
cord-015021-pol2qm74	3997	1	lls~	lls~	CD
cord-015021-pol2qm74	3997	2	sepsis	sepsis	NN
cord-015021-pol2qm74	3997	3	~nd	~nd	NNP
cord-015021-pol2qm74	3997	4	MOF	MOF	NNP
cord-015021-pol2qm74	3997	5	.	.	.
cord-015021-pol2qm74	3998	1	The	the	DT
cord-015021-pol2qm74	3998	2	impaired	impaired	JJ
cord-015021-pol2qm74	3998	3	immune	immune	JJ
cord-015021-pol2qm74	3998	4	response	response	NN
cord-015021-pol2qm74	3998	5	associated	associate	VBN
cord-015021-pol2qm74	3998	6	with	with	IN
cord-015021-pol2qm74	3998	7	multiple	multiple	JJ
cord-015021-pol2qm74	3998	8	system	system	NN
cord-015021-pol2qm74	3998	9	organ	organ	NN
cord-015021-pol2qm74	3998	10	failure	failure	NN
cord-015021-pol2qm74	3998	11	(	(	-LRB-
cord-015021-pol2qm74	3998	12	MSOF	MSOF	NNP
cord-015021-pol2qm74	3998	13	)	)	-RRB-
cord-015021-pol2qm74	3998	14	has	have	VBZ
cord-015021-pol2qm74	3998	15	been	be	VBN
cord-015021-pol2qm74	3998	16	most	most	RBS
cord-015021-pol2qm74	3998	17	widely	widely	RB
cord-015021-pol2qm74	3998	18	studied	study	VBN
cord-015021-pol2qm74	3998	19	following	follow	VBG
cord-015021-pol2qm74	3998	20	surgery	surgery	NN
cord-015021-pol2qm74	3998	21	for	for	IN
cord-015021-pol2qm74	3998	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	3998	23	disease	disease	NN
cord-015021-pol2qm74	3998	24	and	and	CC
cord-015021-pol2qm74	3998	25	trauma	trauma	NN
cord-015021-pol2qm74	3998	26	.	.	.
cord-015021-pol2qm74	3999	1	The	the	DT
cord-015021-pol2qm74	3999	2	majority	majority	NN
cord-015021-pol2qm74	3999	3	of	of	IN
cord-015021-pol2qm74	3999	4	late	late	JJ
cord-015021-pol2qm74	3999	5	deaths	death	NNS
cord-015021-pol2qm74	3999	6	following	follow	VBG
cord-015021-pol2qm74	3999	7	trauma	trauma	NN
cord-015021-pol2qm74	3999	8	are	be	VBP
cord-015021-pol2qm74	3999	9	due	due	JJ
cord-015021-pol2qm74	3999	10	to	to	IN
cord-015021-pol2qm74	3999	11	infection	infection	NN
cord-015021-pol2qm74	3999	12	and	and	CC
cord-015021-pol2qm74	3999	13	MSOF	MSOF	NNP
cord-015021-pol2qm74	3999	14	.	.	.
cord-015021-pol2qm74	4000	1	Not	not	RB
cord-015021-pol2qm74	4000	2	all	all	DT
cord-015021-pol2qm74	4000	3	patients	patient	NNS
cord-015021-pol2qm74	4000	4	with	with	IN
cord-015021-pol2qm74	4000	5	multiple	multiple	JJ
cord-015021-pol2qm74	4000	6	organ	organ	NN
cord-015021-pol2qm74	4000	7	failure	failure	NN
cord-015021-pol2qm74	4000	8	have	have	VBP
cord-015021-pol2qm74	4000	9	concomitant	concomitant	JJ
cord-015021-pol2qm74	4000	10	infection	infection	NN
cord-015021-pol2qm74	4000	11	present	present	JJ
cord-015021-pol2qm74	4000	12	,	,	,
cord-015021-pol2qm74	4000	13	yet	yet	CC
cord-015021-pol2qm74	4000	14	most	most	JJS
cord-015021-pol2qm74	4000	15	have	have	VBP
cord-015021-pol2qm74	4000	16	been	be	VBN
cord-015021-pol2qm74	4000	17	septic	septic	JJ
cord-015021-pol2qm74	4000	18	at	at	IN
cord-015021-pol2qm74	4000	19	some	some	DT
cord-015021-pol2qm74	4000	20	time	time	NN
cord-015021-pol2qm74	4000	21	in	in	IN
cord-015021-pol2qm74	4000	22	their	-PRON-	PRP$
cord-015021-pol2qm74	4000	23	hospital	hospital	NN
cord-015021-pol2qm74	4000	24	course	course	NN
cord-015021-pol2qm74	4000	25	.	.	.
cord-015021-pol2qm74	4001	1	Their	-PRON-	PRP$
cord-015021-pol2qm74	4001	2	generalized	generalized	JJ
cord-015021-pol2qm74	4001	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4001	4	condition	condition	NN
cord-015021-pol2qm74	4001	5	often	often	RB
cord-015021-pol2qm74	4001	6	persists	persist	VBZ
cord-015021-pol2qm74	4001	7	whether	whether	IN
cord-015021-pol2qm74	4001	8	or	or	CC
cord-015021-pol2qm74	4001	9	not	not	RB
cord-015021-pol2qm74	4001	10	organisms	organism	NNS
cord-015021-pol2qm74	4001	11	have	have	VBP
cord-015021-pol2qm74	4001	12	been	be	VBN
cord-015021-pol2qm74	4001	13	recovered	recover	VBN
cord-015021-pol2qm74	4001	14	.	.	.
cord-015021-pol2qm74	4002	1	Immune	immune	JJ
cord-015021-pol2qm74	4002	2	failure	failure	NN
cord-015021-pol2qm74	4002	3	probably	probably	RB
cord-015021-pol2qm74	4002	4	precedes	precede	VBZ
cord-015021-pol2qm74	4002	5	MSOF	MSOF	NNP
cord-015021-pol2qm74	4002	6	with	with	IN
cord-015021-pol2qm74	4002	7	or	or	CC
cord-015021-pol2qm74	4002	8	without	without	IN
cord-015021-pol2qm74	4002	9	overt	overt	JJ
cord-015021-pol2qm74	4002	10	infection	infection	NN
cord-015021-pol2qm74	4002	11	and	and	CC
cord-015021-pol2qm74	4002	12	indeed	indeed	RB
cord-015021-pol2qm74	4002	13	may	may	MD
cord-015021-pol2qm74	4002	14	perpetuate	perpetuate	VB
cord-015021-pol2qm74	4002	15	such	such	JJ
cord-015021-pol2qm74	4002	16	widespread	widespread	JJ
cord-015021-pol2qm74	4002	17	sepsis	sepsis	NN
cord-015021-pol2qm74	4002	18	.	.	.
cord-015021-pol2qm74	4003	1	Macrophage	macrophage	NN
cord-015021-pol2qm74	4003	2	tumor	tumor	NN
cord-015021-pol2qm74	4003	3	necrosis	necrosis	NN
cord-015021-pol2qm74	4003	4	factor	factor	NN
cord-015021-pol2qm74	4003	5	-	-	HYPH
cord-015021-pol2qm74	4003	6	alpha	alpha	NN
cord-015021-pol2qm74	4003	7	(	(	-LRB-
cord-015021-pol2qm74	4003	8	TNF	TNF	NNP
cord-015021-pol2qm74	4003	9	)	)	-RRB-
cord-015021-pol2qm74	4003	10	production	production	NN
cord-015021-pol2qm74	4003	11	is	be	VBZ
cord-015021-pol2qm74	4003	12	thought	think	VBN
cord-015021-pol2qm74	4003	13	to	to	TO
cord-015021-pol2qm74	4003	14	represent	represent	VB
cord-015021-pol2qm74	4003	15	an	an	DT
cord-015021-pol2qm74	4003	16	important	important	JJ
cord-015021-pol2qm74	4003	17	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	4003	18	mechanism	mechanism	NN
cord-015021-pol2qm74	4003	19	by	by	IN
cord-015021-pol2qm74	4003	20	which	which	WDT
cord-015021-pol2qm74	4003	21	this	this	DT
cord-015021-pol2qm74	4003	22	is	be	VBZ
cord-015021-pol2qm74	4003	23	mediated	mediate	VBN
cord-015021-pol2qm74	4003	24	.	.	.
cord-015021-pol2qm74	4004	1	Cecal	Cecal	NNP
cord-015021-pol2qm74	4004	2	ligation	ligation	NN
cord-015021-pol2qm74	4004	3	and	and	CC
cord-015021-pol2qm74	4004	4	puncture	puncture	NN
cord-015021-pol2qm74	4004	5	(	(	-LRB-
cord-015021-pol2qm74	4004	6	CLP	CLP	NNP
cord-015021-pol2qm74	4004	7	)	)	-RRB-
cord-015021-pol2qm74	4004	8	is	be	VBZ
cord-015021-pol2qm74	4004	9	a	a	DT
cord-015021-pol2qm74	4004	10	clinically	clinically	RB
cord-015021-pol2qm74	4004	11	relevant	relevant	JJ
cord-015021-pol2qm74	4004	12	murine	murine	JJ
cord-015021-pol2qm74	4004	13	model	model	NN
cord-015021-pol2qm74	4004	14	of	of	IN
cord-015021-pol2qm74	4004	15	intra	intra	JJ
cord-015021-pol2qm74	4004	16	-	-	JJ
cord-015021-pol2qm74	4004	17	abdominal	abdominal	JJ
cord-015021-pol2qm74	4004	18	infection	infection	NN
cord-015021-pol2qm74	4004	19	and	and	CC
cord-015021-pol2qm74	4004	20	sepsis	sepsis	NN
cord-015021-pol2qm74	4004	21	.	.	.
cord-015021-pol2qm74	4005	1	Serum	serum	NN
cord-015021-pol2qm74	4005	2	TNF	tnf	NN
cord-015021-pol2qm74	4005	3	and	and	CC
cord-015021-pol2qm74	4005	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4005	5	levels	level	NNS
cord-015021-pol2qm74	4005	6	,	,	,
cord-015021-pol2qm74	4005	7	and	and	CC
cord-015021-pol2qm74	4005	8	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4005	9	macrophage	macrophage	NN
cord-015021-pol2qm74	4005	10	TNF	TNF	NNP
cord-015021-pol2qm74	4005	11	production	production	NN
cord-015021-pol2qm74	4005	12	are	be	VBP
cord-015021-pol2qm74	4005	13	only	only	RB
cord-015021-pol2qm74	4005	14	slightly	slightly	RB
cord-015021-pol2qm74	4005	15	elevated	elevated	JJ
cord-015021-pol2qm74	4005	16	in	in	IN
cord-015021-pol2qm74	4005	17	this	this	DT
cord-015021-pol2qm74	4005	18	model	model	NN
cord-015021-pol2qm74	4005	19	even	even	RB
cord-015021-pol2qm74	4005	20	in	in	IN
cord-015021-pol2qm74	4005	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4005	22	sensitive	sensitive	JJ
cord-015021-pol2qm74	4005	23	animals	animal	NNS
cord-015021-pol2qm74	4005	24	.	.	.
cord-015021-pol2qm74	4006	1	Mortality	mortality	NN
cord-015021-pol2qm74	4006	2	in	in	IN
cord-015021-pol2qm74	4006	3	this	this	DT
cord-015021-pol2qm74	4006	4	model	model	NN
cord-015021-pol2qm74	4006	5	,	,	,
cord-015021-pol2qm74	4006	6	therefore	therefore	RB
cord-015021-pol2qm74	4006	7	,	,	,
cord-015021-pol2qm74	4006	8	does	do	VBZ
cord-015021-pol2qm74	4006	9	not	not	RB
cord-015021-pol2qm74	4006	10	appear	appear	VB
cord-015021-pol2qm74	4006	11	to	to	TO
cord-015021-pol2qm74	4006	12	be	be	VB
cord-015021-pol2qm74	4006	13	attributed	attribute	VBN
cord-015021-pol2qm74	4006	14	to	to	IN
cord-015021-pol2qm74	4006	15	overwhelming	overwhelming	JJ
cord-015021-pol2qm74	4006	16	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4006	17	and/or	and/or	CC
cord-015021-pol2qm74	4006	18	TNF	TNF	NNP
cord-015021-pol2qm74	4006	19	production	production	NN
cord-015021-pol2qm74	4006	20	.	.	.
cord-015021-pol2qm74	4007	1	It	-PRON-	PRP
cord-015021-pol2qm74	4007	2	has	have	VBZ
cord-015021-pol2qm74	4007	3	therefore	therefore	RB
cord-015021-pol2qm74	4007	4	been	be	VBN
cord-015021-pol2qm74	4007	5	postulated	postulate	VBN
cord-015021-pol2qm74	4007	6	that	that	IN
cord-015021-pol2qm74	4007	7	TNF	TNF	NNP
cord-015021-pol2qm74	4007	8	and	and	CC
cord-015021-pol2qm74	4007	9	other	other	JJ
cord-015021-pol2qm74	4007	10	cytokines	cytokine	NNS
cord-015021-pol2qm74	4007	11	may	may	MD
cord-015021-pol2qm74	4007	12	act	act	VB
cord-015021-pol2qm74	4007	13	in	in	IN
cord-015021-pol2qm74	4007	14	a	a	DT
cord-015021-pol2qm74	4007	15	paracrine	paracrine	JJ
cord-015021-pol2qm74	4007	16	fashion	fashion	NN
cord-015021-pol2qm74	4007	17	to	to	TO
cord-015021-pol2qm74	4007	18	Cause	cause	VB
cord-015021-pol2qm74	4007	19	local	local	JJ
cord-015021-pol2qm74	4007	20	injury	injury	NN
cord-015021-pol2qm74	4007	21	.	.	.
cord-015021-pol2qm74	4008	1	TNF	TNF	NNP
cord-015021-pol2qm74	4008	2	messenger	messenger	NN
cord-015021-pol2qm74	4008	3	RNA	RNA	NNP
cord-015021-pol2qm74	4008	4	(	(	-LRB-
cord-015021-pol2qm74	4008	5	mRNA	mrna	NN
cord-015021-pol2qm74	4008	6	)	)	-RRB-
cord-015021-pol2qm74	4008	7	expression	expression	NN
cord-015021-pol2qm74	4008	8	was	be	VBD
cord-015021-pol2qm74	4008	9	therefore	therefore	RB
cord-015021-pol2qm74	4008	10	measured	measure	VBN
cord-015021-pol2qm74	4008	11	and	and	CC
cord-015021-pol2qm74	4008	12	found	find	VBD
cord-015021-pol2qm74	4008	13	to	to	TO
cord-015021-pol2qm74	4008	14	be	be	VB
cord-015021-pol2qm74	4008	15	increased	increase	VBN
cord-015021-pol2qm74	4008	16	in	in	IN
cord-015021-pol2qm74	4008	17	the	the	DT
cord-015021-pol2qm74	4008	18	lung	lung	NN
cord-015021-pol2qm74	4008	19	and	and	CC
cord-015021-pol2qm74	4008	20	liver	liver	NN
cord-015021-pol2qm74	4008	21	following	follow	VBG
cord-015021-pol2qm74	4008	22	CLP	CLP	NNP
cord-015021-pol2qm74	4008	23	.	.	.
cord-015021-pol2qm74	4009	1	A	a	DT
cord-015021-pol2qm74	4009	2	different	different	JJ
cord-015021-pol2qm74	4009	3	pattern	pattern	NN
cord-015021-pol2qm74	4009	4	of	of	IN
cord-015021-pol2qm74	4009	5	expression	expression	NN
cord-015021-pol2qm74	4009	6	was	be	VBD
cord-015021-pol2qm74	4009	7	seen	see	VBN
cord-015021-pol2qm74	4009	8	after	after	IN
cord-015021-pol2qm74	4009	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4009	10	administration	administration	NN
cord-015021-pol2qm74	4009	11	,	,	,
cord-015021-pol2qm74	4009	12	characterized	characterize	VBN
cord-015021-pol2qm74	4009	13	by	by	IN
cord-015021-pol2qm74	4009	14	a	a	DT
cord-015021-pol2qm74	4009	15	more	more	RBR
cord-015021-pol2qm74	4009	16	rapid	rapid	JJ
cord-015021-pol2qm74	4009	17	rise	rise	NN
cord-015021-pol2qm74	4009	18	and	and	CC
cord-015021-pol2qm74	4009	19	fall	fall	VB
cord-015021-pol2qm74	4009	20	,	,	,
cord-015021-pol2qm74	4009	21	and	and	CC
cord-015021-pol2qm74	4009	22	enhanced	enhance	VBD
cord-015021-pol2qm74	4009	23	TNF	TNF	NNP
cord-015021-pol2qm74	4009	24	mRNA	mrna	NN
cord-015021-pol2qm74	4009	25	expression	expression	NN
cord-015021-pol2qm74	4009	26	in	in	IN
cord-015021-pol2qm74	4009	27	the	the	DT
cord-015021-pol2qm74	4009	28	spleen	spleen	NN
cord-015021-pol2qm74	4009	29	as	as	RB
cord-015021-pol2qm74	4009	30	well	well	RB
cord-015021-pol2qm74	4009	31	.	.	.
cord-015021-pol2qm74	4010	1	Route	route	NN
cord-015021-pol2qm74	4010	2	of	of	IN
cord-015021-pol2qm74	4010	3	spread	spread	NN
cord-015021-pol2qm74	4010	4	of	of	IN
cord-015021-pol2qm74	4010	5	infection	infection	NN
cord-015021-pol2qm74	4010	6	as	as	RB
cord-015021-pol2qm74	4010	7	well	well	RB
cord-015021-pol2qm74	4010	8	as	as	IN
cord-015021-pol2qm74	4010	9	the	the	DT
cord-015021-pol2qm74	4010	10	type	type	NN
cord-015021-pol2qm74	4010	11	of	of	IN
cord-015021-pol2qm74	4010	12	stimulus	stimulus	NN
cord-015021-pol2qm74	4010	13	may	may	MD
cord-015021-pol2qm74	4010	14	determine	determine	VB
cord-015021-pol2qm74	4010	15	the	the	DT
cord-015021-pol2qm74	4010	16	organ	organ	NN
cord-015021-pol2qm74	4010	17	specific	specific	JJ
cord-015021-pol2qm74	4010	18	cytokine	cytokine	NN
cord-015021-pol2qm74	4010	19	response	response	NN
cord-015021-pol2qm74	4010	20	.	.	.
cord-015021-pol2qm74	4011	1	These	these	DT
cord-015021-pol2qm74	4011	2	data	datum	NNS
cord-015021-pol2qm74	4011	3	support	support	VBP
cord-015021-pol2qm74	4011	4	the	the	DT
cord-015021-pol2qm74	4011	5	concept	concept	NN
cord-015021-pol2qm74	4011	6	of	of	IN
cord-015021-pol2qm74	4011	7	locally	locally	RB
cord-015021-pol2qm74	4011	8	produced	produce	VBN
cord-015021-pol2qm74	4011	9	TNF	TNF	NNP
cord-015021-pol2qm74	4011	10	as	as	IN
cord-015021-pol2qm74	4011	11	a	a	DT
cord-015021-pol2qm74	4011	12	contributing	contribute	VBG
cord-015021-pol2qm74	4011	13	factor	factor	NN
cord-015021-pol2qm74	4011	14	in	in	IN
cord-015021-pol2qm74	4011	15	tissue	tissue	NN
cord-015021-pol2qm74	4011	16	damage	damage	NN
cord-015021-pol2qm74	4011	17	and	and	CC
cord-015021-pol2qm74	4011	18	multiple	multiple	JJ
cord-015021-pol2qm74	4011	19	organ	organ	NN
cord-015021-pol2qm74	4011	20	failure	failure	NN
cord-015021-pol2qm74	4011	21	during	during	IN
cord-015021-pol2qm74	4011	22	sepsis	sepsis	NN
cord-015021-pol2qm74	4011	23	.	.	.
cord-015021-pol2qm74	4012	1	The	the	DT
cord-015021-pol2qm74	4012	2	estimation	estimation	NN
cord-015021-pol2qm74	4012	3	of	of	IN
cord-015021-pol2qm74	4012	4	histamine	histamine	NN
cord-015021-pol2qm74	4012	5	's	's	POS
cord-015021-pol2qm74	4012	6	role	role	NN
cord-015021-pol2qm74	4012	7	in	in	IN
cord-015021-pol2qm74	4012	8	SIRS	SIRS	NNP
cord-015021-pol2qm74	4012	9	changed	change	VBD
cord-015021-pol2qm74	4012	10	over	over	IN
cord-015021-pol2qm74	4012	11	the	the	DT
cord-015021-pol2qm74	4012	12	years	year	NNS
cord-015021-pol2qm74	4012	13	based	base	VBN
cord-015021-pol2qm74	4012	14	on	on	IN
cord-015021-pol2qm74	4012	15	increased	increase	VBN
cord-015021-pol2qm74	4012	16	knowledge	knowledge	NN
cord-015021-pol2qm74	4012	17	in	in	IN
cord-015021-pol2qm74	4012	18	shock	shock	NN
cord-015021-pol2qm74	4012	19	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	4012	20	,	,	,
cord-015021-pol2qm74	4012	21	evidence	evidence	NN
cord-015021-pol2qm74	4012	22	later	later	RB
cord-015021-pol2qm74	4012	23	found	find	VBD
cord-015021-pol2qm74	4012	24	to	to	TO
cord-015021-pol2qm74	4012	25	be	be	VB
cord-015021-pol2qm74	4012	26	faulty	faulty	JJ
cord-015021-pol2qm74	4012	27	,	,	,
cord-015021-pol2qm74	4012	28	and	and	CC
cord-015021-pol2qm74	4012	29	the	the	DT
cord-015021-pol2qm74	4012	30	discovery	discovery	NN
cord-015021-pol2qm74	4012	31	of	of	IN
cord-015021-pol2qm74	4012	32	other	other	JJ
cord-015021-pol2qm74	4012	33	,	,	,
cord-015021-pol2qm74	4012	34	more	more	RBR
cord-015021-pol2qm74	4012	35	fashionable	fashionable	JJ
cord-015021-pol2qm74	4012	36	mediators	mediator	NNS
cord-015021-pol2qm74	4012	37	.	.	.
cord-015021-pol2qm74	4013	1	Over	over	IN
cord-015021-pol2qm74	4013	2	the	the	DT
cord-015021-pol2qm74	4013	3	decades	decade	NNS
cord-015021-pol2qm74	4013	4	,	,	,
cord-015021-pol2qm74	4013	5	the	the	DT
cord-015021-pol2qm74	4013	6	prevailing	prevail	VBG
cord-015021-pol2qm74	4013	7	view	view	NN
cord-015021-pol2qm74	4013	8	has	have	VBZ
cord-015021-pol2qm74	4013	9	been	be	VBN
cord-015021-pol2qm74	4013	10	that	that	IN
cord-015021-pol2qm74	4013	11	histamine	histamine	NN
cord-015021-pol2qm74	4013	12	is	be	VBZ
cord-015021-pol2qm74	4013	13	a	a	DT
cord-015021-pol2qm74	4013	14	noxious	noxious	JJ
cord-015021-pol2qm74	4013	15	mediator	mediator	NN
cord-015021-pol2qm74	4013	16	contributing	contribute	VBG
cord-015021-pol2qm74	4013	17	to	to	IN
cord-015021-pol2qm74	4013	18	the	the	DT
cord-015021-pol2qm74	4013	19	fatal	fatal	JJ
cord-015021-pol2qm74	4013	20	outcome	outcome	NN
cord-015021-pol2qm74	4013	21	of	of	IN
cord-015021-pol2qm74	4013	22	shock	shock	NN
cord-015021-pol2qm74	4013	23	.	.	.
cord-015021-pol2qm74	4014	1	The	the	DT
cord-015021-pol2qm74	4014	2	analysis	analysis	NN
cord-015021-pol2qm74	4014	3	of	of	IN
cord-015021-pol2qm74	4014	4	experimental	experimental	JJ
cord-015021-pol2qm74	4014	5	data	datum	NNS
cord-015021-pol2qm74	4014	6	on	on	IN
cord-015021-pol2qm74	4014	7	exogenously	exogenously	RB
cord-015021-pol2qm74	4014	8	administered	administer	VBN
cord-015021-pol2qm74	4014	9	,	,	,
cord-015021-pol2qm74	4014	10	endogenously	endogenously	RB
cord-015021-pol2qm74	4014	11	released	release	VBN
cord-015021-pol2qm74	4014	12	and/or	and/or	CC
cord-015021-pol2qm74	4014	13	newly	newly	RB
cord-015021-pol2qm74	4014	14	formed	form	VBN
cord-015021-pol2qm74	4014	15	histamine	histamine	NN
cord-015021-pol2qm74	4014	16	in	in	IN
cord-015021-pol2qm74	4014	17	septic	septic	JJ
cord-015021-pol2qm74	4014	18	/	/	SYM
cord-015021-pol2qm74	4014	19	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	4014	20	shock	shock	NN
cord-015021-pol2qm74	4014	21	suggests	suggest	VBZ
cord-015021-pol2qm74	4014	22	that	that	IN
cord-015021-pol2qm74	4014	23	histamine	histamine	NN
cord-015021-pol2qm74	4014	24	contributes	contribute	VBZ
cord-015021-pol2qm74	4014	25	to	to	IN
cord-015021-pol2qm74	4014	26	the	the	DT
cord-015021-pol2qm74	4014	27	early	early	JJ
cord-015021-pol2qm74	4014	28	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	4014	29	changes	change	NNS
cord-015021-pol2qm74	4014	30	via	via	IN
cord-015021-pol2qm74	4014	31	HI	hi	NN
cord-015021-pol2qm74	4014	32	-	-	HYPH
cord-015021-pol2qm74	4014	33	receptor	receptor	NN
cord-015021-pol2qm74	4014	34	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	4014	35	thus	thus	RB
cord-015021-pol2qm74	4014	36	excerbating	excerbate	VBG
cord-015021-pol2qm74	4014	37	(	(	-LRB-
cord-015021-pol2qm74	4014	38	directly	directly	RB
cord-015021-pol2qm74	4014	39	and	and	CC
cord-015021-pol2qm74	4014	40	indirectly	indirectly	RB
cord-015021-pol2qm74	4014	41	)	)	-RRB-
cord-015021-pol2qm74	4014	42	the	the	DT
cord-015021-pol2qm74	4014	43	effects	effect	NNS
cord-015021-pol2qm74	4014	44	of	of	IN
cord-015021-pol2qm74	4014	45	catecholamines	catecholamine	NNS
cord-015021-pol2qm74	4014	46	.	.	.
cord-015021-pol2qm74	4015	1	In	in	IN
cord-015021-pol2qm74	4015	2	the	the	DT
cord-015021-pol2qm74	4015	3	later	later	JJ
cord-015021-pol2qm74	4015	4	phase	phase	NN
cord-015021-pol2qm74	4015	5	of	of	IN
cord-015021-pol2qm74	4015	6	septic	septic	JJ
cord-015021-pol2qm74	4015	7	shock	shock	NN
cord-015021-pol2qm74	4015	8	(	(	-LRB-
cord-015021-pol2qm74	4015	9	low	low	RB
cord-015021-pol2qm74	4015	10	out	out	RB
cord-015021-pol2qm74	4015	11	-	-	HYPH
cord-015021-pol2qm74	4015	12	put	put	NN
cord-015021-pol2qm74	4015	13	,	,	,
cord-015021-pol2qm74	4015	14	high	high	JJ
cord-015021-pol2qm74	4015	15	resistance	resistance	NN
cord-015021-pol2qm74	4015	16	states	state	NNS
cord-015021-pol2qm74	4015	17	)	)	-RRB-
cord-015021-pol2qm74	4015	18	,	,	,
cord-015021-pol2qm74	4015	19	however	however	RB
cord-015021-pol2qm74	4015	20	,	,	,
cord-015021-pol2qm74	4015	21	it	-PRON-	PRP
cord-015021-pol2qm74	4015	22	can	can	MD
cord-015021-pol2qm74	4015	23	be	be	VB
cord-015021-pol2qm74	4015	24	assumed	assume	VBN
cord-015021-pol2qm74	4015	25	that	that	IN
cord-015021-pol2qm74	4015	26	histamine	histamine	NN
cord-015021-pol2qm74	4015	27	exerts	exert	VBZ
cord-015021-pol2qm74	4015	28	strong	strong	JJ
cord-015021-pol2qm74	4015	29	vasodilator	vasodilator	NN
cord-015021-pol2qm74	4015	30	and	and	CC
cord-015021-pol2qm74	4015	31	positive	positive	JJ
cord-015021-pol2qm74	4015	32	inotropic	inotropic	NNP
cord-015021-pol2qm74	4015	33	effects	effect	NNS
cord-015021-pol2qm74	4015	34	via	via	IN
cord-015021-pol2qm74	4015	35	H2-receptors	h2-receptor	NNS
cord-015021-pol2qm74	4015	36	.	.	.
cord-015021-pol2qm74	4016	1	These	these	DT
cord-015021-pol2qm74	4016	2	effects	effect	NNS
cord-015021-pol2qm74	4016	3	are	be	VBP
cord-015021-pol2qm74	4016	4	considered	consider	VBN
cord-015021-pol2qm74	4016	5	beneficial	beneficial	JJ
cord-015021-pol2qm74	4016	6	in	in	IN
cord-015021-pol2qm74	4016	7	counteracting	counteract	VBG
cord-015021-pol2qm74	4016	8	or	or	CC
cord-015021-pol2qm74	4016	9	attenuating	attenuate	VBG
cord-015021-pol2qm74	4016	10	the	the	DT
cord-015021-pol2qm74	4016	11	effects	effect	NNS
cord-015021-pol2qm74	4016	12	of	of	IN
cord-015021-pol2qm74	4016	13	sympathetic	sympathetic	JJ
cord-015021-pol2qm74	4016	14	responses	response	NNS
cord-015021-pol2qm74	4016	15	of	of	IN
cord-015021-pol2qm74	4016	16	catecholamines	catecholamine	NNS
cord-015021-pol2qm74	4016	17	and	and	CC
cord-015021-pol2qm74	4016	18	other	other	JJ
cord-015021-pol2qm74	4016	19	mediators	mediator	NNS
cord-015021-pol2qm74	4016	20	.	.	.
cord-015021-pol2qm74	4017	1	Thus	thus	RB
cord-015021-pol2qm74	4017	2	,	,	,
cord-015021-pol2qm74	4017	3	a	a	DT
cord-015021-pol2qm74	4017	4	blockade	blockade	NN
cord-015021-pol2qm74	4017	5	of	of	IN
cord-015021-pol2qm74	4017	6	the	the	DT
cord-015021-pol2qm74	4017	7	early	early	JJ
cord-015021-pol2qm74	4017	8	reaction	reaction	NN
cord-015021-pol2qm74	4017	9	with	with	IN
cord-015021-pol2qm74	4017	10	Hi	Hi	NNP
cord-015021-pol2qm74	4017	11	-	-	HYPH
cord-015021-pol2qm74	4017	12	antagonists	antagonist	NNS
cord-015021-pol2qm74	4017	13	and	and	CC
cord-015021-pol2qm74	4017	14	a	a	DT
cord-015021-pol2qm74	4017	15	stimulation	stimulation	NN
cord-015021-pol2qm74	4017	16	of	of	IN
cord-015021-pol2qm74	4017	17	the	the	DT
cord-015021-pol2qm74	4017	18	H2-receptors	h2-receptor	NNS
cord-015021-pol2qm74	4017	19	by	by	IN
cord-015021-pol2qm74	4017	20	H2-agonists	h2-agonist	NNS
cord-015021-pol2qm74	4017	21	are	be	VBP
cord-015021-pol2qm74	4017	22	worthwhile	worthwhile	JJ
cord-015021-pol2qm74	4017	23	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	4017	24	approaches	approach	NNS
cord-015021-pol2qm74	4017	25	.	.	.
cord-015021-pol2qm74	4018	1	Shock	shock	NN
cord-015021-pol2qm74	4018	2	produc~	produc~	NNS
cord-015021-pol2qm74	4019	1	s	s	NNP
cord-015021-pol2qm74	4019	2	~IJ	~ij	XX
cord-015021-pol2qm74	4020	1	alterations	alteration	NNS
cord-015021-pol2qm74	4020	2	,	,	,
cord-015021-pol2qm74	4020	3	an	an	DT
cord-015021-pol2qm74	4020	4	encrgy	encrgy	NNP
cord-015021-pol2qm74	4020	5	crisis	crisis	NN
cord-015021-pol2qm74	4020	6	and	and	CC
cord-015021-pol2qm74	4020	7	eventual	eventual	JJ
cord-015021-pol2qm74	4020	8	c	c	NN
cord-015021-pol2qm74	4020	9	~	~	NFP
cord-015021-pol2qm74	4020	10	ll	ll	VB
cord-015021-pol2qm74	4020	11	damage	damage	NN
cord-015021-pol2qm74	4020	12	,	,	.
cord-015021-pol2qm74	4021	1	However	however	RB
cord-015021-pol2qm74	4021	2	,	,	,
cord-015021-pol2qm74	4021	3	shock	shock	NN
cord-015021-pol2qm74	4021	4	in	in	IN
cord-015021-pol2qm74	4021	5	itse|f	itse|f	JJ
cord-015021-pol2qm74	4021	6	do~	do~	NN
cord-015021-pol2qm74	4021	7	not	not	RB
cord-015021-pol2qm74	4021	8	lead	lead	VB
cord-015021-pol2qm74	4021	9	freqoenfly	freqoenfly	NN
cord-015021-pol2qm74	4021	10	to	to	IN
cord-015021-pol2qm74	4021	11	r	r	NN
cord-015021-pol2qm74	4021	12	~	~	NFP
cord-015021-pol2qm74	4021	13	mote	mote	NNP
cord-015021-pol2qm74	4021	14	organ	organ	NN
cord-015021-pol2qm74	4021	15	damage	damage	NN
cord-015021-pol2qm74	4021	16	.	.	.
cord-015021-pol2qm74	4022	1	In	in	IN
cord-015021-pol2qm74	4022	2	animal	animal	NN
cord-015021-pol2qm74	4022	3	~xpcrhnents	~xpcrhnent	NNS
cord-015021-pol2qm74	4022	4	and	and	CC
cord-015021-pol2qm74	4022	5	clinical	clinical	JJ
cord-015021-pol2qm74	4022	6	expariez	expariez	NN
cord-015021-pol2qm74	4022	7	:	:	:
cord-015021-pol2qm74	4022	8	ces	ces	NNP
cord-015021-pol2qm74	4022	9	in	in	IN
cord-015021-pol2qm74	4022	10	Korea	Korea	NNP
cord-015021-pol2qm74	4022	11	and	and	CC
cord-015021-pol2qm74	4022	12	Vietnam	Vietnam	NNP
cord-015021-pol2qm74	4022	13	,	,	,
cord-015021-pol2qm74	4022	14	shock	shock	NN
cord-015021-pol2qm74	4022	15	I	-PRON-	PRP
cord-015021-pol2qm74	4023	1	~r	~r	NNP
cord-015021-pol2qm74	4023	2	s¢	s¢	NNP
cord-015021-pol2qm74	4023	3	was	be	VBD
cord-015021-pol2qm74	4023	4	not	not	RB
cord-015021-pol2qm74	4023	5	associated	associate	VBN
cord-015021-pol2qm74	4023	6	with	with	IN
cord-015021-pol2qm74	4023	7	lung	lung	NN
cord-015021-pol2qm74	4023	8	damage	damage	NN
cord-015021-pol2qm74	4023	9	,	,	,
cord-015021-pol2qm74	4023	10	renal	renal	JJ
cord-015021-pol2qm74	4023	11	failure	failure	NN
cord-015021-pol2qm74	4023	12	or	or	CC
cord-015021-pol2qm74	4023	13	ARDS	ARDS	NNP
cord-015021-pol2qm74	4023	14	.	.	.
cord-015021-pol2qm74	4024	1	The	the	DT
cord-015021-pol2qm74	4024	2	same	same	JJ
cord-015021-pol2qm74	4024	3	is	be	VBZ
cord-015021-pol2qm74	4024	4	true	true	JJ
cord-015021-pol2qm74	4024	5	with	with	IN
cord-015021-pol2qm74	4024	6	G.L	G.L	NNP
cord-015021-pol2qm74	4024	7	bleeding	bleed	VBG
cord-015021-pol2qm74	4024	8	.	.	.
cord-015021-pol2qm74	4025	1	However	however	RB
cord-015021-pol2qm74	4025	2	,	,	,
cord-015021-pol2qm74	4025	3	when	when	WRB
cord-015021-pol2qm74	4025	4	shock	shock	NN
cord-015021-pol2qm74	4025	5	is	be	VBZ
cord-015021-pol2qm74	4025	6	due	due	JJ
cord-015021-pol2qm74	4025	7	to	to	IN
cord-015021-pol2qm74	4025	8	trauma	trauma	NN
cord-015021-pol2qm74	4025	9	or	or	CC
cord-015021-pol2qm74	4025	10	associated	associate	VBN
cord-015021-pol2qm74	4025	11	with	with	IN
cord-015021-pol2qm74	4025	12	tlssus	tlssus	NNP
cord-015021-pol2qm74	4025	13	injmy	injmy	NNP
cord-015021-pol2qm74	4025	14	,	,	,
cord-015021-pol2qm74	4025	15	then	then	RB
cord-015021-pol2qm74	4025	16	organ	organ	NN
cord-015021-pol2qm74	4025	17	malfunction	malfunction	NN
cord-015021-pol2qm74	4025	18	m	m	NNP
cord-015021-pol2qm74	4025	19	~	~	NFP
cord-015021-pol2qm74	4025	20	d	d	NN
cord-015021-pol2qm74	4025	21	damage	damage	NN
cord-015021-pol2qm74	4025	22	is	be	VBZ
cord-015021-pol2qm74	4025	23	frequent	frequent	JJ
cord-015021-pol2qm74	4025	24	.	.	.
cord-015021-pol2qm74	4026	1	Shock	shock	NN
cord-015021-pol2qm74	4026	2	is	be	VBZ
cord-015021-pol2qm74	4026	3	bclleved	bclleve	VBN
cord-015021-pol2qm74	4026	4	to	to	TO
cord-015021-pol2qm74	4026	5	increase	increase	VB
cord-015021-pol2qm74	4026	6	the	the	DT
cord-015021-pol2qm74	4026	7	frequency	frequency	NN
cord-015021-pol2qm74	4026	8	of	of	IN
cord-015021-pol2qm74	4026	9	infection	infection	NN
cord-015021-pol2qm74	4026	10	,	,	,
cord-015021-pol2qm74	4026	11	but	but	CC
cord-015021-pol2qm74	4026	12	clinical	clinical	JJ
cord-015021-pol2qm74	4026	13	evidcnc~	evidcnc~	NNP
cord-015021-pol2qm74	4026	14	for	for	IN
cord-015021-pol2qm74	4026	15	this	this	DT
cord-015021-pol2qm74	4026	16	is	be	VBZ
cord-015021-pol2qm74	4026	17	scant	scant	JJ
cord-015021-pol2qm74	4026	18	.	.	.
cord-015021-pol2qm74	4027	1	Hemonhsgio	Hemonhsgio	NNP
cord-015021-pol2qm74	4027	2	shock	shock	NN
cord-015021-pol2qm74	4027	3	akme	akme	NNP
cord-015021-pol2qm74	4027	4	is	be	VBZ
cord-015021-pol2qm74	4027	5	an	an	DT
cord-015021-pol2qm74	4027	6	unusual	unusual	JJ
cord-015021-pol2qm74	4027	7	o	o	NN
cord-015021-pol2qm74	4027	8	~	~	NFP
cord-015021-pol2qm74	4027	9	orrenee	orrenee	NNP
cord-015021-pol2qm74	4027	10	dinica[ly	dinica[ly	NNP
cord-015021-pol2qm74	4027	11	.	.	.
cord-015021-pol2qm74	4028	1	Immune	immune	JJ
cord-015021-pol2qm74	4028	2	dysfolletion	dysfolletion	NN
cord-015021-pol2qm74	4028	3	dons	don	NNS
cord-015021-pol2qm74	4028	4	occur	occur	VBP
cord-015021-pol2qm74	4028	5	witl~	witl~	NNP
cord-015021-pol2qm74	4028	6	experhnental	experhnental	JJ
cord-015021-pol2qm74	4028	7	hypovolemic	hypovolemic	JJ
cord-015021-pol2qm74	4028	8	shock	shock	NN
cord-015021-pol2qm74	4028	9	and	and	CC
cord-015021-pol2qm74	4029	1	in	in	IN
cord-015021-pol2qm74	4029	2	pailcnts	pailcnt	NNS
cord-015021-pol2qm74	4029	3	with	with	IN
cord-015021-pol2qm74	4029	4	hypotcnsion	hypotcnsion	NN
cord-015021-pol2qm74	4029	5	or	or	CC
cord-015021-pol2qm74	4029	6	after	after	IN
cord-015021-pol2qm74	4029	7	receiving	receive	VBG
cord-015021-pol2qm74	4029	8	blood	blood	NN
cord-015021-pol2qm74	4029	9	~ansfosions	~ansfosions	NFP
cord-015021-pol2qm74	4029	10	.	.	.
cord-015021-pol2qm74	4030	1	Tbc	Tbc	NNP
cord-015021-pol2qm74	4030	2	most	most	RBS
cord-015021-pol2qm74	4030	3	significant	significant	JJ
cord-015021-pol2qm74	4030	4	factor	factor	NN
cord-015021-pol2qm74	4030	5	affecting	affect	VBG
cord-015021-pol2qm74	4030	6	reoorrcnce	reoorrcnce	NN
cord-015021-pol2qm74	4030	7	of	of	IN
cord-015021-pol2qm74	4030	8	resented	resent	VBN
cord-015021-pol2qm74	4030	9	ca	ca	NNP
cord-015021-pol2qm74	4030	10	,	,	,
cord-015021-pol2qm74	4030	11	lorectal	lorectal	NNP
cord-015021-pol2qm74	4030	12	liver	liver	NNP
cord-015021-pol2qm74	4030	13	mclastasis	mclastasis	NNP
cord-015021-pol2qm74	4030	14	was	be	VBD
cord-015021-pol2qm74	4030	15	hypotensivc	hypotensivc	NNP
cord-015021-pol2qm74	4030	16	episodes	episode	NNS
cord-015021-pol2qm74	4030	17	during	during	IN
cord-015021-pol2qm74	4030	18	operation	operation	NN
cord-015021-pol2qm74	4030	19	.	.	.
cord-015021-pol2qm74	4031	1	Blood	blood	NN
cord-015021-pol2qm74	4031	2	transfosions	transfosion	NNS
cord-015021-pol2qm74	4031	3	depreSs	depress	POS
cord-015021-pol2qm74	4031	4	immune	immune	JJ
cord-015021-pol2qm74	4031	5	function	function	NN
cord-015021-pol2qm74	4031	6	,	,	,
cord-015021-pol2qm74	4031	7	improve	improve	VB
cord-015021-pol2qm74	4031	8	transplant	transplant	NN
cord-015021-pol2qm74	4032	1	~raft	~raft	NFP
cord-015021-pol2qm74	4032	2	survival	survival	NN
cord-015021-pol2qm74	4032	3	and	and	CC
cord-015021-pol2qm74	4032	4	increase	increase	NN
cord-015021-pol2qm74	4032	5	ttll'rmr	ttll'rmr	SYM
cord-015021-pol2qm74	4032	6	rec~	rec~	CD
cord-015021-pol2qm74	4033	1	R'Tcnos	R'Tcnos	NNP
cord-015021-pol2qm74	4033	2	ill	ill	JJ
cord-015021-pol2qm74	4033	3	co[eli	co[eli	NN
cord-015021-pol2qm74	4033	4	and	and	CC
cord-015021-pol2qm74	4033	5	head	head	NN
cord-015021-pol2qm74	4033	6	and	and	CC
cord-015021-pol2qm74	4033	7	nc	nc	NNP
cord-015021-pol2qm74	4034	1	~k	~k	LS
cord-015021-pol2qm74	4034	2	cancers	cancer	NNS
cord-015021-pol2qm74	4034	3	.	.	.
cord-015021-pol2qm74	4035	1	In	in	IN
cord-015021-pol2qm74	4035	2	experimental	experimental	JJ
cord-015021-pol2qm74	4035	3	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	4035	4	shock	shock	NN
cord-015021-pol2qm74	4035	5	,	,	,
cord-015021-pol2qm74	4035	6	we	-PRON-	PRP
cord-015021-pol2qm74	4035	7	found	find	VBD
cord-015021-pol2qm74	4035	8	decreased	decreased	JJ
cord-015021-pol2qm74	4035	9	response	response	NN
cord-015021-pol2qm74	4035	10	of	of	IN
cord-015021-pol2qm74	4035	11	[	[	-LRB-
cord-015021-pol2qm74	4035	12	ymphocytes	ymphocyte	NNS
cord-015021-pol2qm74	4035	13	to	to	IN
cord-015021-pol2qm74	4035	14	mitogens	mitogens	NNP
cord-015021-pol2qm74	4035	15	,	,	,
cord-015021-pol2qm74	4035	16	el	el	NNP
cord-015021-pol2qm74	4035	17	:	:	:
cord-015021-pol2qm74	4035	18	clad	clothe	VBN
cord-015021-pol2qm74	4035	19	mixed	mixed	JJ
cord-015021-pol2qm74	4035	20	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4035	21	reactilln	reactilln	NN
cord-015021-pol2qm74	4035	22	and	and	CC
cord-015021-pol2qm74	4035	23	I[,-2	I[,-2	NNP
cord-015021-pol2qm74	4035	24	decreased	decrease	VBD
cord-015021-pol2qm74	4035	25	.	.	.
cord-015021-pol2qm74	4036	1	Othe~.x	othe~.x	JJ
cord-015021-pol2qm74	4036	2	hsvc	hsvc	NNP
cord-015021-pol2qm74	4036	3	found	find	VBD
cord-015021-pol2qm74	4036	4	decreased	decreased	JJ
cord-015021-pol2qm74	4036	5	macrophage	macrophage	NN
cord-015021-pol2qm74	4036	6	and	and	CC
cord-015021-pol2qm74	4036	7	T	t	NN
cord-015021-pol2qm74	4036	8	and	and	CC
cord-015021-pol2qm74	4036	9	B	B	NNP
cord-015021-pol2qm74	4036	10	¢¢lt	¢¢lt	NNP
cord-015021-pol2qm74	4036	11	function	function	NN
cord-015021-pol2qm74	4036	12	,	,	,
cord-015021-pol2qm74	4036	13	deci	deci	NNP
cord-015021-pol2qm74	4036	14	~	~	NFP
cord-015021-pol2qm74	4036	15	ased	ased	NNP
cord-015021-pol2qm74	4036	16	re	re	NNP
cord-015021-pol2qm74	4036	17	,	,	,
cord-015021-pol2qm74	4036	18	ease	ease	NN
cord-015021-pol2qm74	4036	19	of	of	IN
cord-015021-pol2qm74	4036	20	/	/	SYM
cord-015021-pol2qm74	4036	21	L	l	NN
cord-015021-pol2qm74	4037	1	~I	~I	NFP
cord-015021-pol2qm74	4037	2	,	,	,
cord-015021-pol2qm74	4037	3	increased	increase	VBN
cord-015021-pol2qm74	4037	4	POE	POE	NNP
cord-015021-pol2qm74	4037	5	v	v	NN
cord-015021-pol2qm74	4037	6	depressed	depressed	JJ
cord-015021-pol2qm74	4037	7	macrophagc	macrophagc	NN
cord-015021-pol2qm74	4037	8	antigen	antigen	NNP
cord-015021-pol2qm74	4037	9	presanlatiota	presanlatiota	NNP
cord-015021-pol2qm74	4037	10	,	,	,
cord-015021-pol2qm74	4037	11	increased	increase	VBD
cord-015021-pol2qm74	4037	12	IEN	IEN	NNP
cord-015021-pol2qm74	4037	13	y	y	NNP
cord-015021-pol2qm74	4037	14	,	,	,
cord-015021-pol2qm74	4037	15	decreased	decrease	VBD
cord-015021-pol2qm74	4037	16	IL-2	IL-2	NNP
cord-015021-pol2qm74	4037	17	,	,	,
cord-015021-pol2qm74	4037	18	3	3	CD
cord-015021-pol2qm74	4037	19	and	and	CC
cord-015021-pol2qm74	4037	20	5	5	CD
cord-015021-pol2qm74	4037	21	,	,	,
cord-015021-pol2qm74	4037	22	and	and	CC
cord-015021-pol2qm74	4037	23	shared	share	VBN
cord-015021-pol2qm74	4037	24	mscrophags	mscrophags	JJ
cord-015021-pol2qm74	4037	25	funclion	funclion	NN
cord-015021-pol2qm74	4037	26	with	with	IN
cord-015021-pol2qm74	4037	27	loss	loss	NN
cord-015021-pol2qm74	4037	28	nr	nr	NNP
cord-015021-pol2qm74	4037	29	F	F	NNP
cord-015021-pol2qm74	4037	30	and	and	CC
cord-015021-pol2qm74	4037	31	C	C	NNP
cord-015021-pol2qm74	4037	32	3B	3b	NN
cord-015021-pol2qm74	4037	33	r	r	NN
cord-015021-pol2qm74	4038	1	~ccpto~	~ccpto~	NFP
cord-015021-pol2qm74	4039	1	s.	s.	NNP
cord-015021-pol2qm74	4040	1	This	this	DT
cord-015021-pol2qm74	4040	2	is	be	VBZ
cord-015021-pol2qm74	4040	3	inhibited	inhibit	VBN
cord-015021-pol2qm74	4040	4	by	by	IN
cord-015021-pol2qm74	4040	5	chlornqoine	chlornqoine	NN
cord-015021-pol2qm74	4040	6	,	,	,
cord-015021-pol2qm74	4040	7	ibuprofen	ibuprofen	NNP
cord-015021-pol2qm74	4040	8	,	,	,
cord-015021-pol2qm74	4040	9	dihiazem	dihiazem	NNP
cord-015021-pol2qm74	4040	10	,	,	,
cord-015021-pol2qm74	4040	11	and	and	CC
cord-015021-pol2qm74	4040	12	ATP	ATP	NNP
cord-015021-pol2qm74	4040	13	.	.	.
cord-015021-pol2qm74	4041	1	Shock	shock	NN
cord-015021-pol2qm74	4041	2	may	may	MD
cord-015021-pol2qm74	4041	3	activate	activate	VB
cord-015021-pol2qm74	4041	4	ncutrophils	ncutrophils	NNP
cord-015021-pol2qm74	4041	5	contributing	contribute	VBG
cord-015021-pol2qm74	4041	6	to	to	IN
cord-015021-pol2qm74	4041	7	ilappitlg	ilappitlg	NNP
cord-015021-pol2qm74	4041	8	in	in	IN
cord-015021-pol2qm74	4041	9	cspillarics	cspillaric	NNS
cord-015021-pol2qm74	4041	10	,	,	,
cord-015021-pol2qm74	4041	11	no	no	DT
cord-015021-pol2qm74	4041	12	refluw	refluw	NN
cord-015021-pol2qm74	4041	13	,	,	,
cord-015021-pol2qm74	4041	14	increased	increase	VBN
cord-015021-pol2qm74	4041	15	adhesion	adhesion	NN
cord-015021-pol2qm74	4041	16	,	,	,
cord-015021-pol2qm74	4041	17	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	4041	18	and	and	CC
cord-015021-pol2qm74	4041	19	organ	organ	NN
cord-015021-pol2qm74	4041	20	damage	damage	NN
cord-015021-pol2qm74	4041	21	.	.	.
cord-015021-pol2qm74	4042	1	This	this	DT
cord-015021-pol2qm74	4042	2	may	may	MD
cord-015021-pol2qm74	4042	3	be	be	VB
cord-015021-pol2qm74	4042	4	related	relate	VBN
cord-015021-pol2qm74	4042	5	to	to	IN
cord-015021-pol2qm74	4042	6	decreased	decrease	VBN
cord-015021-pol2qm74	4042	7	clearance	clearance	NN
cord-015021-pol2qm74	4042	8	of	of	IN
cord-015021-pol2qm74	4042	9	bacteria	bacteria	NNS
cord-015021-pol2qm74	4042	10	after	after	IN
cord-015021-pol2qm74	4042	11	shock	shock	NN
cord-015021-pol2qm74	4042	12	.	.	.
cord-015021-pol2qm74	4043	1	T	T	NNP
cord-015021-pol2qm74	4043	2	~	~	CD
cord-015021-pol2qm74	4043	3	lls	lls	NNP
cord-015021-pol2qm74	4043	4	shock	shock	NN
cord-015021-pol2qm74	4043	5	,	,	,
cord-015021-pol2qm74	4043	6	hypotcnsion	hypotcnsion	NN
cord-015021-pol2qm74	4043	7	and	and	CC
cord-015021-pol2qm74	4043	8	decreased	decrease	VBD
cord-015021-pol2qm74	4043	9	microcirculatory	microcirculatory	NNP
cord-015021-pol2qm74	4043	10	blued	blued	JJ
cord-015021-pol2qm74	4043	11	flow	flow	NN
cord-015021-pol2qm74	4043	12	initiate	initiate	VB
cord-015021-pol2qm74	4043	13	or	or	CC
cord-015021-pol2qm74	4043	14	set	set	VB
cord-015021-pol2qm74	4043	15	the	the	DT
cord-015021-pol2qm74	4043	16	stage	stage	NN
cord-015021-pol2qm74	4043	17	for	for	IN
cord-015021-pol2qm74	4043	18	immune	immune	JJ
cord-015021-pol2qm74	4043	19	dysfmtction	dysfmtction	NN
cord-015021-pol2qm74	4043	20	.	.	.
cord-015021-pol2qm74	4044	1	They	-PRON-	PRP
cord-015021-pol2qm74	4044	2	,	,	,
cord-015021-pol2qm74	4044	3	along	along	IN
cord-015021-pol2qm74	4044	4	with	with	IN
cord-015021-pol2qm74	4044	5	tissue	tissue	NN
cord-015021-pol2qm74	4044	6	injury	injury	NN
cord-015021-pol2qm74	4044	7	trigger	trigger	NN
cord-015021-pol2qm74	4044	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4044	9	cascades	cascade	NNS
cord-015021-pol2qm74	4044	10	.	.	.
cord-015021-pol2qm74	4045	1	This	this	DT
cord-015021-pol2qm74	4045	2	also	also	RB
cord-015021-pol2qm74	4045	3	contributes	contribute	VBZ
cord-015021-pol2qm74	4045	4	to	to	IN
cord-015021-pol2qm74	4045	5	immunologic	immunologic	JJ
cord-015021-pol2qm74	4045	6	dysfonctitm	dysfonctitm	NN
cord-015021-pol2qm74	4045	7	,	,	,
cord-015021-pol2qm74	4045	8	which	which	WDT
cord-015021-pol2qm74	4045	9	is	be	VBZ
cord-015021-pol2qm74	4045	10	associated	associate	VBN
cord-015021-pol2qm74	4045	11	with	with	IN
cord-015021-pol2qm74	4045	12	increased	increase	VBN
cord-015021-pol2qm74	4045	13	Lufoction	Lufoction	NNP
cord-015021-pol2qm74	4045	14	.	.	.
cord-015021-pol2qm74	4046	1	Thus	thus	RB
cord-015021-pol2qm74	4046	2	altered	alter	VBN
cord-015021-pol2qm74	4046	3	bh	bh	NNP
cord-015021-pol2qm74	4046	4	,	,	,
cord-015021-pol2qm74	4046	5	od	od	NNP
cord-015021-pol2qm74	4046	6	flow	flow	NN
cord-015021-pol2qm74	4046	7	and	and	CC
cord-015021-pol2qm74	4046	8	mediator	mediator	NN
cord-015021-pol2qm74	4046	9	cascades	cascade	NNS
cord-015021-pol2qm74	4046	10	are	be	VBP
cord-015021-pol2qm74	4046	11	bolh	bolh	JJ
cord-015021-pol2qm74	4046	12	involved	involve	VBN
cord-015021-pol2qm74	4046	13	,	,	,
cord-015021-pol2qm74	4046	14	The	the	DT
cord-015021-pol2qm74	4046	15	question	question	NN
cord-015021-pol2qm74	4046	16	now	now	RB
cord-015021-pol2qm74	4046	17	is	be	VBZ
cord-015021-pol2qm74	4046	18	can	can	MD
cord-015021-pol2qm74	4046	19	wc	wc	NNP
cord-015021-pol2qm74	4046	20	rapidly	rapidly	RB
cord-015021-pol2qm74	4046	21	improve	improve	VB
cord-015021-pol2qm74	4046	22	microcirculatory	microcirculatory	JJ
cord-015021-pol2qm74	4046	23	blood	blood	NN
cord-015021-pol2qm74	4046	24	flow	flow	NN
cord-015021-pol2qm74	4046	25	,	,	,
cord-015021-pol2qm74	4046	26	and	and	CC
cord-015021-pol2qm74	4046	27	dg'masa	dg'masa	NNP
cord-015021-pol2qm74	4046	28	Inflsrmnatory	Inflsrmnatory	NNP
cord-015021-pol2qm74	4046	29	Fosponss	Fosponss	NNP
cord-015021-pol2qm74	4046	30	,	,	,
cord-015021-pol2qm74	4046	31	which	which	WDT
cord-015021-pol2qm74	4046	32	is	be	VBZ
cord-015021-pol2qm74	4046	33	also	also	RB
cord-015021-pol2qm74	4046	34	necessary	necessary	JJ
cord-015021-pol2qm74	4046	35	for	for	IN
cord-015021-pol2qm74	4046	36	survival	survival	NN
cord-015021-pol2qm74	4047	1	The	the	DT
cord-015021-pol2qm74	4047	2	effe~	effe~	NN
cord-015021-pol2qm74	4047	3	of	of	IN
cord-015021-pol2qm74	4047	4	~nterferon	~nterferon	CD
cord-015021-pol2qm74	4048	1	~amma	~amma	NNP
cord-015021-pol2qm74	4049	1	@n	@n	NNP
cord-015021-pol2qm74	4049	2	wour~	wour~	NNP
cord-015021-pol2qm74	4049	3	healing	healing	NN
cord-015021-pol2qm74	4049	4	was	be	VBD
cord-015021-pol2qm74	4049	5	ewaluated	ewaluate	VBN
cord-015021-pol2qm74	4049	6	~n	~n	NNP
cord-015021-pol2qm74	4049	7	a	a	DT
cord-015021-pol2qm74	4049	8	routine	routine	JJ
cord-015021-pol2qm74	4049	9	mo	mo	NN
cord-015021-pol2qm74	4049	10	~	~	NNP
cord-015021-pol2qm74	4049	11	el	el	NNP
cord-015021-pol2qm74	4049	12	.	.	.
cord-015021-pol2qm74	4050	1	~mma	~mma	NNP
cord-015021-pol2qm74	4051	1	~n	~n	NNP
cord-015021-pol2qm74	4052	1	~erferon	~erferon	NFP
cord-015021-pol2qm74	4052	2	we8	we8	HYPH
cord-015021-pol2qm74	4052	3	g	g	NN
cord-015021-pol2qm74	4053	1	~ven	~ven	NNP
cord-015021-pol2qm74	4053	2	in	in	IN
cord-015021-pol2qm74	4053	3	doses	dose	NNS
cord-015021-pol2qm74	4053	4	of	of	IN
cord-015021-pol2qm74	4053	5	~37.5	~37.5	NN
cord-015021-pol2qm74	4053	6	to	to	IN
cord-015021-pol2qm74	4053	7	~2,500	~2,500	JJ
cord-015021-pol2qm74	4053	8	U~%$	U~%$	NNP
cord-015021-pol2qm74	4053	9	synchronous	synchronous	JJ
cord-015021-pol2qm74	4053	10	with	with	IN
cord-015021-pol2qm74	4053	11	ereatio~	ereatio~	NN
cord-015021-pol2qm74	4053	12	of	of	IN
cord-015021-pol2qm74	4053	13	a	a	DT
cord-015021-pol2qm74	4053	14	pa	pa	NNP
cord-015021-pol2qm74	4054	1	~splnal	~splnal	NNP
cord-015021-pol2qm74	4054	2	woumd	woumd	NNP
cord-015021-pol2qm74	4054	3	then	then	RB
cord-015021-pol2qm74	4054	4	daily	daily	RB
cord-015021-pol2qm74	4054	5	for	for	IN
cord-015021-pol2qm74	4054	6	IS	be	VBZ
cord-015021-pol2qm74	4054	7	~lays	~lays	NFP
cord-015021-pol2qm74	4054	8	.	.	.
cord-015021-pol2qm74	4054	9	~mteET	~mteET	NFP
cord-015021-pol2qm74	4055	1	~on	~on	NNP
cord-015021-pol2qm74	4055	2	~amma	~amma	NNP
cord-015021-pol2qm74	4055	3	impaired	impair	VBD
cord-015021-pol2qm74	4055	4	tensile	tensile	JJ
cord-015021-pol2qm74	4055	5	strength	strength	NN
cord-015021-pol2qm74	4055	6	a%	a%	''
cord-015021-pol2qm74	4055	7	all	all	DT
cord-015021-pol2qm74	4055	8	~oses	~oses	NFP
cord-015021-pol2qm74	4055	9	relative	relative	NN
cord-015021-pol2qm74	4055	10	to	to	IN
cord-015021-pol2qm74	4055	11	control	control	NN
cord-015021-pol2qm74	4055	12	.	.	.
cord-015021-pol2qm74	4056	1	M0zphology	M0zphology	NNP
cord-015021-pol2qm74	4056	2	suggested	suggest	VBD
cord-015021-pol2qm74	4056	3	~reas~	~reas~	NNP
cord-015021-pol2qm74	4056	4	¢oll	¢oll	ADD
cord-015021-pol2qm74	4056	5	~	~	NFP
cord-015021-pol2qm74	4056	6	gen	gen	NNP
cord-015021-pol2qm74	4056	7	deposition	deposition	NNP
cord-015021-pol2qm74	4056	8	and	and	CC
cord-015021-pol2qm74	4056	9	r	r	NNP
cord-015021-pol2qm74	4056	10	~	~	NFP
cord-015021-pol2qm74	4056	11	du~-~	du~-~	NNP
cord-015021-pol2qm74	4056	12	neovag	neovag	NNP
cord-015021-pol2qm74	4057	1	~ulaEit¥	~ulaEit¥	NFP
cord-015021-pol2qm74	4058	1	~n	~n	NNP
cord-015021-pol2qm74	4059	1	t~	t~	ADD
cord-015021-pol2qm74	4060	1	eat~4	eat~4	NNP
cord-015021-pol2qm74	4060	2	animals	animal	NNS
cord-015021-pol2qm74	4060	3	,	,	,
cord-015021-pol2qm74	4060	4	Interferon	Interferon	NNP
cord-015021-pol2qm74	4061	1	~amma	~amma	NNP
cord-015021-pol2qm74	4061	2	was	be	VBD
cord-015021-pol2qm74	4061	3	a2so	a2so	NNP
cord-015021-pol2qm74	4061	4	~valuated	~valuated	NNP
cord-015021-pol2qm74	4061	5	in	in	IN
cord-015021-pol2qm74	4061	6	a	a	DT
cord-015021-pol2qm74	4061	7	murine	murine	JJ
cord-015021-pol2qm74	4061	8	mo	mo	NN
cord-015021-pol2qm74	4062	1	~el	~el	NNP
cord-015021-pol2qm74	4062	2	of	of	IN
cord-015021-pol2qm74	4062	3	cecal	cecal	NNP
cord-015021-pol2qm74	4062	4	llgatlon	llgatlon	NNP
cord-015021-pol2qm74	4062	5	and	and	CC
cord-015021-pol2qm74	4062	6	punneure	punneure	NNP
cord-015021-pol2qm74	4062	7	.	.	.
cord-015021-pol2qm74	4063	1	One	one	CD
cord-015021-pol2qm74	4063	2	hundred	hundred	CD
cord-015021-pol2qm74	4063	3	tO	to	TO
cord-015021-pol2qm74	4063	4	22,S00	22,s00	CD
cord-015021-pol2qm74	4063	5	uni~	uni~	CD
cord-015021-pol2qm74	4063	6	vere	vere	NNP
cord-015021-pol2qm74	4063	7	~iv.n	~iv.n	NN
cord-015021-pol2qm74	4064	1	following	follow	VBG
cord-015021-pol2qm74	4064	2	~nju~	~nju~	IN
cord-015021-pol2qm74	4064	3	an~	an~	NNP
cord-015021-pol2qm74	4064	4	than	than	IN
cord-015021-pol2qm74	4064	5	daily	daily	RB
cord-015021-pol2qm74	4064	6	.	.	.
cord-015021-pol2qm74	4065	1	Interferon	Interferon	NNP
cord-015021-pol2qm74	4065	2	qamma	qamma	NNP
cord-015021-pol2qm74	4065	3	was	be	VBD
cord-015021-pol2qm74	4065	4	associated	associate	VBN
cord-015021-pol2qm74	4065	5	with	with	IN
cord-015021-pol2qm74	4065	6	inco	inco	NNP
cord-015021-pol2qm74	4065	7	:	:	:
cord-015021-pol2qm74	4066	1	ea	ea	NNP
cord-015021-pol2qm74	4067	1	~ed	~ed	NNP
cord-015021-pol2qm74	4067	2	mortalit~	mortalit~	NNP
cord-015021-pol2qm74	4067	3	and	and	CC
cord-015021-pol2qm74	4067	4	earlier	early	JJR
cord-015021-pol2qm74	4067	5	death	death	NN
cord-015021-pol2qm74	4068	1	a~/a	a~/a	NNP
cord-015021-pol2qm74	4069	1	~n	~n	NNP
cord-015021-pol2qm74	4069	2	~n	~n	NFP
cord-015021-pol2qm74	4069	3	a	a	DT
cord-015021-pol2qm74	4069	4	dose	dose	NN
cord-015021-pol2qm74	4069	5	dependant	dependant	JJ
cord-015021-pol2qm74	4069	6	manner	manner	NN
cord-015021-pol2qm74	4069	7	(	(	-LRB-
cord-015021-pol2qm74	4069	8	P	p	NN
cord-015021-pol2qm74	4069	9	<	<	XX
cord-015021-pol2qm74	4069	10	0,05	0,05	NN
cord-015021-pol2qm74	4069	11	)	)	-RRB-
cord-015021-pol2qm74	4069	12	.	.	.
cord-015021-pol2qm74	4070	1	Afmlnistra	Afmlnistra	NNP
cord-015021-pol2qm74	4070	2	~	~	NFP
cord-015021-pol2qm74	4070	3	ion	ion	NN
cord-015021-pol2qm74	4071	1	The	the	DT
cord-015021-pol2qm74	4071	2	proinfiammatory	proinfiammatory	JJ
cord-015021-pol2qm74	4071	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	4071	4	tumor	tumor	NN
cord-015021-pol2qm74	4071	5	necrosis	necrosis	NN
cord-015021-pol2qm74	4071	6	factor	factor	NN
cord-015021-pol2qm74	4071	7	-	-	:
cord-015021-pol2qm74	4071	8	c~	c~	XX
cord-015021-pol2qm74	4072	1	(	(	-LRB-
cord-015021-pol2qm74	4072	2	TNF	TNF	NNP
cord-015021-pol2qm74	4072	3	-	-	HYPH
cord-015021-pol2qm74	4072	4	c0	c0	NNP
cord-015021-pol2qm74	4072	5	,	,	,
cord-015021-pol2qm74	4072	6	interleukin-16	interleukin-16	FW
cord-015021-pol2qm74	4072	7	(	(	-LRB-
cord-015021-pol2qm74	4072	8	IL	IL	NNP
cord-015021-pol2qm74	4072	9	-	-	HYPH
cord-015021-pol2qm74	4072	10	II3	II3	NNP
cord-015021-pol2qm74	4072	11	)	)	-RRB-
cord-015021-pol2qm74	4072	12	,	,	.
cord-015021-pol2qm74	4073	1	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	4073	2	(	(	-LRB-
cord-015021-pol2qm74	4073	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	4073	4	)	)	-RRB-
cord-015021-pol2qm74	4073	5	,	,	,
cord-015021-pol2qm74	4073	6	and	and	CC
cord-015021-pol2qm74	4073	7	interleukin-8	interleukin-8	NNP
cord-015021-pol2qm74	4073	8	(	(	-LRB-
cord-015021-pol2qm74	4073	9	IL-8	il-8	NN
cord-015021-pol2qm74	4073	10	)	)	-RRB-
cord-015021-pol2qm74	4073	11	have	have	VBP
cord-015021-pol2qm74	4073	12	been	be	VBN
cord-015021-pol2qm74	4073	13	implicated	implicate	VBN
cord-015021-pol2qm74	4073	14	in	in	IN
cord-015021-pol2qm74	4073	15	the	the	DT
cord-015021-pol2qm74	4073	16	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	4073	17	of	of	IN
cord-015021-pol2qm74	4073	18	the	the	DT
cord-015021-pol2qm74	4073	19	multiple	multiple	JJ
cord-015021-pol2qm74	4073	20	organ	organ	NN
cord-015021-pol2qm74	4073	21	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4073	22	syndrome	syndrome	NN
cord-015021-pol2qm74	4073	23	(	(	-LRB-
cord-015021-pol2qm74	4073	24	MODS	MODS	NNP
cord-015021-pol2qm74	4073	25	)	)	-RRB-
cord-015021-pol2qm74	4073	26	following	follow	VBG
cord-015021-pol2qm74	4073	27	shock	shock	NN
cord-015021-pol2qm74	4073	28	and	and	CC
cord-015021-pol2qm74	4073	29	trauma	trauma	NN
cord-015021-pol2qm74	4073	30	.	.	.
cord-015021-pol2qm74	4074	1	These	these	DT
cord-015021-pol2qm74	4074	2	mediators	mediator	NNS
cord-015021-pol2qm74	4074	3	which	which	WDT
cord-015021-pol2qm74	4074	4	are	be	VBP
cord-015021-pol2qm74	4074	5	released	release	VBN
cord-015021-pol2qm74	4074	6	in	in	IN
cord-015021-pol2qm74	4074	7	high	high	JJ
cord-015021-pol2qm74	4074	8	concentrations	concentration	NNS
cord-015021-pol2qm74	4074	9	by	by	IN
cord-015021-pol2qm74	4074	10	activated	activate	VBN
cord-015021-pol2qm74	4074	11	macrophages	macrophage	NNS
cord-015021-pol2qm74	4074	12	,	,	,
cord-015021-pol2qm74	4074	13	endothelial	endothelial	JJ
cord-015021-pol2qm74	4074	14	cells	cell	NNS
cord-015021-pol2qm74	4074	15	,	,	,
cord-015021-pol2qm74	4074	16	and	and	CC
cord-015021-pol2qm74	4074	17	connective	connective	JJ
cord-015021-pol2qm74	4074	18	tissue	tissue	NN
cord-015021-pol2qm74	4074	19	cells	cell	NNS
cord-015021-pol2qm74	4074	20	cause	cause	VBP
cord-015021-pol2qm74	4074	21	a	a	DT
cord-015021-pol2qm74	4074	22	systemic	systemic	JJ
cord-015021-pol2qm74	4074	23	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4074	24	response	response	NN
cord-015021-pol2qm74	4074	25	syndrome	syndrome	NN
cord-015021-pol2qm74	4074	26	(	(	-LRB-
cord-015021-pol2qm74	4074	27	SIRS	SIRS	NNP
cord-015021-pol2qm74	4074	28	)	)	-RRB-
cord-015021-pol2qm74	4074	29	,	,	,
cord-015021-pol2qm74	4074	30	thus	thus	RB
cord-015021-pol2qm74	4074	31	leading	lead	VBG
cord-015021-pol2qm74	4074	32	to	to	IN
cord-015021-pol2qm74	4074	33	a	a	DT
cord-015021-pol2qm74	4074	34	shock	shock	NN
cord-015021-pol2qm74	4074	35	-	-	HYPH
cord-015021-pol2qm74	4074	36	like	like	JJ
cord-015021-pol2qm74	4074	37	state	state	NN
cord-015021-pol2qm74	4074	38	and	and	CC
cord-015021-pol2qm74	4074	39	tissue	tissue	NN
cord-015021-pol2qm74	4074	40	destruction	destruction	NN
cord-015021-pol2qm74	4074	41	.	.	.
cord-015021-pol2qm74	4075	1	Recently	recently	RB
cord-015021-pol2qm74	4075	2	,	,	,
cord-015021-pol2qm74	4075	3	a	a	DT
cord-015021-pol2qm74	4075	4	number	number	NN
cord-015021-pol2qm74	4075	5	of	of	IN
cord-015021-pol2qm74	4075	6	proteins	protein	NNS
cord-015021-pol2qm74	4075	7	have	have	VBP
cord-015021-pol2qm74	4075	8	been	be	VBN
cord-015021-pol2qm74	4075	9	characterized	characterize	VBN
cord-015021-pol2qm74	4075	10	in	in	IN
cord-015021-pol2qm74	4075	11	in	in	IN
cord-015021-pol2qm74	4075	12	vitro	vitro	FW
cord-015021-pol2qm74	4075	13	and	and	CC
cord-015021-pol2qm74	4075	14	in	in	IN
cord-015021-pol2qm74	4075	15	vivo	vivo	NNP
cord-015021-pol2qm74	4075	16	studies	study	NNS
cord-015021-pol2qm74	4075	17	demonstrating	demonstrate	VBG
cord-015021-pol2qm74	4075	18	potent	potent	JJ
cord-015021-pol2qm74	4075	19	anti	anti	JJ
cord-015021-pol2qm74	4075	20	-	-	JJ
cord-015021-pol2qm74	4075	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4075	22	properties	property	NNS
cord-015021-pol2qm74	4075	23	.	.	.
cord-015021-pol2qm74	4076	1	These	these	DT
cord-015021-pol2qm74	4076	2	latter	latter	JJ
cord-015021-pol2qm74	4076	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	4076	4	include	include	VBP
cord-015021-pol2qm74	4076	5	interleukin-4	interleukin-4	NNP
cord-015021-pol2qm74	4076	6	(	(	-LRB-
cord-015021-pol2qm74	4076	7	IL-4	IL-4	NNP
cord-015021-pol2qm74	4076	8	)	)	-RRB-
cord-015021-pol2qm74	4076	9	,	,	,
cord-015021-pol2qm74	4076	10	interleukin-10	interleukin-10	FW
cord-015021-pol2qm74	4076	11	(	(	-LRB-
cord-015021-pol2qm74	4076	12	IL=10	IL=10	NNP
cord-015021-pol2qm74	4076	13	)	)	-RRB-
cord-015021-pol2qm74	4076	14	,	,	,
cord-015021-pol2qm74	4076	15	transforming	transform	VBG
cord-015021-pol2qm74	4076	16	growth	growth	NN
cord-015021-pol2qm74	4076	17	factor-6	factor-6	IN
cord-015021-pol2qm74	4076	18	(	(	-LRB-
cord-015021-pol2qm74	4076	19	TGF	TGF	NNP
cord-015021-pol2qm74	4076	20	-	-	HYPH
cord-015021-pol2qm74	4076	21	J3	J3	NNP
cord-015021-pol2qm74	4076	22	)	)	-RRB-
cord-015021-pol2qm74	4076	23	,	,	,
cord-015021-pol2qm74	4076	24	and	and	CC
cord-015021-pol2qm74	4076	25	the	the	DT
cord-015021-pol2qm74	4076	26	newly	newly	RB
cord-015021-pol2qm74	4076	27	sequenced	sequence	VBN
cord-015021-pol2qm74	4076	28	interleukin-13	interleukin-13	NN
cord-015021-pol2qm74	4076	29	(	(	-LRB-
cord-015021-pol2qm74	4076	30	IL	IL	NNP
cord-015021-pol2qm74	4076	31	-	-	HYPH
cord-015021-pol2qm74	4076	32	I3	I3	NNP
cord-015021-pol2qm74	4076	33	)	)	-RRB-
cord-015021-pol2qm74	4076	34	.	.	.
cord-015021-pol2qm74	4077	1	They	-PRON-	PRP
cord-015021-pol2qm74	4077	2	are	be	VBP
cord-015021-pol2qm74	4077	3	considered	consider	VBN
cord-015021-pol2qm74	4077	4	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	4077	5	,	,	,
cord-015021-pol2qm74	4077	6	since	since	IN
cord-015021-pol2qm74	4077	7	in	in	FW
cord-015021-pol2qm74	4077	8	vitro	vitro	FW
cord-015021-pol2qm74	4077	9	studies	study	NNS
cord-015021-pol2qm74	4077	10	using	use	VBG
cord-015021-pol2qm74	4077	11	purified	purify	VBN
cord-015021-pol2qm74	4077	12	macrophage	macrophage	NN
cord-015021-pol2qm74	4077	13	cultures	culture	NNS
cord-015021-pol2qm74	4077	14	or	or	CC
cord-015021-pol2qm74	4077	15	whole	whole	JJ
cord-015021-pol2qm74	4077	16	blood	blood	NN
cord-015021-pol2qm74	4077	17	assays	assay	NNS
cord-015021-pol2qm74	4077	18	revealed	reveal	VBD
cord-015021-pol2qm74	4077	19	an	an	DT
cord-015021-pol2qm74	4077	20	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	4077	21	effect	effect	NN
cord-015021-pol2qm74	4077	22	of	of	IN
cord-015021-pol2qm74	4077	23	these	these	DT
cord-015021-pol2qm74	4077	24	antMnfiammatory	antmnfiammatory	IN
cord-015021-pol2qm74	4077	25	cytokines	cytokine	NNS
cord-015021-pol2qm74	4077	26	on	on	IN
cord-015021-pol2qm74	4077	27	~he	~he	JJ
cord-015021-pol2qm74	4077	28	synthesis	synthesis	NN
cord-015021-pol2qm74	4077	29	and	and	CC
cord-015021-pol2qm74	4077	30	release	release	NN
cord-015021-pol2qm74	4077	31	of	of	IN
cord-015021-pol2qm74	4077	32	TNF	TNF	NNP
cord-015021-pol2qm74	4077	33	-	-	HYPH
cord-015021-pol2qm74	4077	34	cL	cL	NNP
cord-015021-pol2qm74	4077	35	and	and	CC
cord-015021-pol2qm74	4077	36	IL	IL	NNP
cord-015021-pol2qm74	4077	37	-	-	HYPH
cord-015021-pol2qm74	4077	38	U3	U3	NNP
cord-015021-pol2qm74	4077	39	.	.	.
cord-015021-pol2qm74	4078	1	In	in	IN
cord-015021-pol2qm74	4078	2	addition	addition	NN
cord-015021-pol2qm74	4078	3	,	,	,
cord-015021-pol2qm74	4078	4	they	-PRON-	PRP
cord-015021-pol2qm74	4078	5	reduced	reduce	VBD
cord-015021-pol2qm74	4078	6	the	the	DT
cord-015021-pol2qm74	4078	7	severity	severity	NN
cord-015021-pol2qm74	4078	8	of	of	IN
cord-015021-pol2qm74	4078	9	disease	disease	NN
cord-015021-pol2qm74	4078	10	and	and	CC
cord-015021-pol2qm74	4078	11	reduce	reduce	VB
cord-015021-pol2qm74	4078	12	plasma	plasma	NN
cord-015021-pol2qm74	4078	13	levels	level	NNS
cord-015021-pol2qm74	4078	14	of	of	IN
cord-015021-pol2qm74	4078	15	TNF	TNF	NNP
cord-015021-pol2qm74	4078	16	-	-	HYPH
cord-015021-pol2qm74	4078	17	c~	c~	NNP
cord-015021-pol2qm74	4078	18	and	and	CC
cord-015021-pol2qm74	4078	19	IL	IL	NNP
cord-015021-pol2qm74	4078	20	-	-	HYPH
cord-015021-pol2qm74	4078	21	II3	II3	NNP
cord-015021-pol2qm74	4078	22	when	when	WRB
cord-015021-pol2qm74	4078	23	administered	administer	VBN
cord-015021-pol2qm74	4078	24	to	to	IN
cord-015021-pol2qm74	4078	25	animals	animal	NNS
cord-015021-pol2qm74	4078	26	with	with	IN
cord-015021-pol2qm74	4078	27	infection	infection	NN
cord-015021-pol2qm74	4078	28	or	or	CC
cord-015021-pol2qm74	4078	29	inflammation	inflammation	NN
cord-015021-pol2qm74	4078	30	.	.	.
cord-015021-pol2qm74	4079	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	4079	2	,	,	,
cord-015021-pol2qm74	4079	3	naturally	naturally	RB
cord-015021-pol2qm74	4079	4	occurring	occur	VBG
cord-015021-pol2qm74	4079	5	substances	substance	NNS
cord-015021-pol2qm74	4079	6	have	have	VBP
cord-015021-pol2qm74	4079	7	been	be	VBN
cord-015021-pol2qm74	4079	8	described	describe	VBN
cord-015021-pol2qm74	4079	9	that	that	IN
cord-015021-pol2qm74	4079	10	specifically	specifically	RB
cord-015021-pol2qm74	4079	11	neutralize	neutralize	VB
cord-015021-pol2qm74	4079	12	the	the	DT
cord-015021-pol2qm74	4079	13	bioactivity	bioactivity	NN
cord-015021-pol2qm74	4079	14	of	of	IN
cord-015021-pol2qm74	4079	15	IL-1B	IL-1B	NNP
cord-015021-pol2qm74	4079	16	and	and	CC
cord-015021-pol2qm74	4079	17	TNF	TNF	NNP
cord-015021-pol2qm74	4079	18	-	-	HYPH
cord-015021-pol2qm74	4079	19	a	a	NN
cord-015021-pol2qm74	4079	20	.	.	.
cord-015021-pol2qm74	4080	1	The	the	DT
cord-015021-pol2qm74	4080	2	IL-1	IL-1	NNP
cord-015021-pol2qm74	4080	3	receptor	receptor	NN
cord-015021-pol2qm74	4080	4	antagonist	antagonist	NN
cord-015021-pol2qm74	4080	5	(	(	-LRB-
cord-015021-pol2qm74	4080	6	IL	IL	NNP
cord-015021-pol2qm74	4080	7	-	-	HYPH
cord-015021-pol2qm74	4080	8	I	I	NNP
cord-015021-pol2qm74	4080	9	ra	ra	NNP
cord-015021-pol2qm74	4080	10	)	)	-RRB-
cord-015021-pol2qm74	4080	11	is	be	VBZ
cord-015021-pol2qm74	4080	12	related	relate	VBN
cord-015021-pol2qm74	4080	13	structurally	structurally	RB
cord-015021-pol2qm74	4080	14	to	to	IN
cord-015021-pol2qm74	4080	15	IL	IL	NNP
cord-015021-pol2qm74	4080	16	-	-	:
cord-015021-pol2qm74	4080	17	I	-PRON-	PRP
cord-015021-pol2qm74	4080	18	and	and	CC
cord-015021-pol2qm74	4080	19	binds	bind	VBZ
cord-015021-pol2qm74	4080	20	to	to	IN
cord-015021-pol2qm74	4080	21	the	the	DT
cord-015021-pol2qm74	4080	22	same	same	JJ
cord-015021-pol2qm74	4080	23	cell	cell	NN
cord-015021-pol2qm74	4080	24	-	-	HYPH
cord-015021-pol2qm74	4080	25	surface	surface	NN
cord-015021-pol2qm74	4080	26	receptors	receptor	NNS
cord-015021-pol2qm74	4080	27	,	,	,
cord-015021-pol2qm74	4080	28	but	but	CC
cord-015021-pol2qm74	4080	29	does	do	VBZ
cord-015021-pol2qm74	4080	30	not	not	RB
cord-015021-pol2qm74	4080	31	stimulate	stimulate	VB
cord-015021-pol2qm74	4080	32	the	the	DT
cord-015021-pol2qm74	4080	33	cell	cell	NN
cord-015021-pol2qm74	4080	34	.	.	.
cord-015021-pol2qm74	4081	1	In	in	IN
cord-015021-pol2qm74	4081	2	animal	animal	NN
cord-015021-pol2qm74	4081	3	models	model	NNS
cord-015021-pol2qm74	4081	4	orE.	orE.	NNP
cord-015021-pol2qm74	4081	5	coB	coB	NNP
cord-015021-pol2qm74	4081	6	-	-	HYPH
cord-015021-pol2qm74	4081	7	induced	induce	VBN
cord-015021-pol2qm74	4081	8	shock	shock	NN
cord-015021-pol2qm74	4081	9	,	,	,
cord-015021-pol2qm74	4081	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4081	11	bowel	bowel	NN
cord-015021-pol2qm74	4081	12	disease	disease	NN
cord-015021-pol2qm74	4081	13	,	,	,
cord-015021-pol2qm74	4081	14	and	and	CC
cord-015021-pol2qm74	4081	15	peritonitis	peritonitis	NN
cord-015021-pol2qm74	4081	16	,	,	,
cord-015021-pol2qm74	4081	17	injection	injection	NN
cord-015021-pol2qm74	4081	18	of	of	IN
cord-015021-pol2qm74	4081	19	IL	IL	NNP
cord-015021-pol2qm74	4081	20	-	-	HYPH
cord-015021-pol2qm74	4081	21	lra	lra	NNP
cord-015021-pol2qm74	4081	22	significantly	significantly	RB
cord-015021-pol2qm74	4081	23	reduced	reduce	VBD
cord-015021-pol2qm74	4081	24	the	the	DT
cord-015021-pol2qm74	4081	25	severity	severity	NN
cord-015021-pol2qm74	4081	26	of	of	IN
cord-015021-pol2qm74	4081	27	disease	disease	NN
cord-015021-pol2qm74	4081	28	.	.	.
cord-015021-pol2qm74	4082	1	The	the	DT
cord-015021-pol2qm74	4082	2	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	4082	3	of	of	IN
cord-015021-pol2qm74	4082	4	TNF	TNF	NNP
cord-015021-pol2qm74	4082	5	-	-	HYPH
cord-015021-pol2qm74	4082	6	c~	c~	NNP
cord-015021-pol2qm74	4082	7	can	can	MD
cord-015021-pol2qm74	4082	8	be	be	VB
cord-015021-pol2qm74	4082	9	inhibited	inhibit	VBN
cord-015021-pol2qm74	4082	10	through	through	IN
cord-015021-pol2qm74	4082	11	two	two	CD
cord-015021-pol2qm74	4082	12	types	type	NNS
cord-015021-pol2qm74	4082	13	of	of	IN
cord-015021-pol2qm74	4082	14	soluble	soluble	JJ
cord-015021-pol2qm74	4082	15	TNF	TNF	NNP
cord-015021-pol2qm74	4082	16	receptors	receptor	NNS
cord-015021-pol2qm74	4082	17	(	(	-LRB-
cord-015021-pol2qm74	4082	18	sTNFR	stnfr	NN
cord-015021-pol2qm74	4082	19	)	)	-RRB-
cord-015021-pol2qm74	4082	20	type	type	NN
cord-015021-pol2qm74	4082	21	I	-PRON-	PRP
cord-015021-pol2qm74	4082	22	(	(	-LRB-
cord-015021-pol2qm74	4082	23	p55	p55	NN
cord-015021-pol2qm74	4082	24	)	)	-RRB-
cord-015021-pol2qm74	4082	25	and	and	CC
cord-015021-pol2qm74	4082	26	type	type	NN
cord-015021-pol2qm74	4082	27	II	II	NNP
cord-015021-pol2qm74	4082	28	(	(	-LRB-
cord-015021-pol2qm74	4082	29	p75	p75	NNP
cord-015021-pol2qm74	4082	30	)	)	-RRB-
cord-015021-pol2qm74	4082	31	.	.	.
cord-015021-pol2qm74	4083	1	These	these	DT
cord-015021-pol2qm74	4083	2	sTNFRs	stnfr	NNS
cord-015021-pol2qm74	4083	3	are	be	VBP
cord-015021-pol2qm74	4083	4	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	4083	5	cleavage	cleavage	NN
cord-015021-pol2qm74	4083	6	products	product	NNS
cord-015021-pol2qm74	4083	7	of	of	IN
cord-015021-pol2qm74	4083	8	the	the	DT
cord-015021-pol2qm74	4083	9	cell	cell	NN
cord-015021-pol2qm74	4083	10	-	-	HYPH
cord-015021-pol2qm74	4083	11	bound	bind	VBN
cord-015021-pol2qm74	4083	12	TNFreceptors	tnfreceptor	NNS
cord-015021-pol2qm74	4083	13	.	.	.
cord-015021-pol2qm74	4084	1	When	when	WRB
cord-015021-pol2qm74	4084	2	given	give	VBN
cord-015021-pol2qm74	4084	3	to	to	IN
cord-015021-pol2qm74	4084	4	baboons	baboon	NNS
cord-015021-pol2qm74	4084	5	to	to	TO
cord-015021-pol2qm74	4084	6	combat	combat	VB
cord-015021-pol2qm74	4084	7	E.	E.	NNP
cord-015021-pol2qm74	4084	8	coil	coil	NN
cord-015021-pol2qm74	4084	9	-	-	HYPH
cord-015021-pol2qm74	4084	10	induced	induce	VBN
cord-015021-pol2qm74	4084	11	shock	shock	NN
cord-015021-pol2qm74	4084	12	,	,	,
cord-015021-pol2qm74	4084	13	soluble	soluble	JJ
cord-015021-pol2qm74	4084	14	receptm	receptm	NN
cord-015021-pol2qm74	4084	15	's	's	POS
cord-015021-pol2qm74	4084	16	to	to	IN
cord-015021-pol2qm74	4084	17	the	the	DT
cord-015021-pol2qm74	4084	18	TNF	TNF	NNP
cord-015021-pol2qm74	4084	19	type	type	NN
cord-015021-pol2qm74	4085	1	[	[	-LRB-
cord-015021-pol2qm74	4085	2	receptor	receptor	NN
cord-015021-pol2qm74	4085	3	decreased	decrease	VBD
cord-015021-pol2qm74	4085	4	the	the	DT
cord-015021-pol2qm74	4085	5	severi~	severi~	NNP
cord-015021-pol2qm74	4085	6	of	of	IN
cord-015021-pol2qm74	4085	7	the	the	DT
cord-015021-pol2qm74	4085	8	shock	shock	NN
cord-015021-pol2qm74	4085	9	-	-	HYPH
cord-015021-pol2qm74	4085	10	like	like	JJ
cord-015021-pol2qm74	4085	11	state	state	NN
cord-015021-pol2qm74	4085	12	.	.	.
cord-015021-pol2qm74	4086	1	It	-PRON-	PRP
cord-015021-pol2qm74	4086	2	has	have	VBZ
cord-015021-pol2qm74	4086	3	been	be	VBN
cord-015021-pol2qm74	4086	4	well	well	RB
cord-015021-pol2qm74	4086	5	accepted	accept	VBN
cord-015021-pol2qm74	4086	6	that	that	DT
cord-015021-pol2qm74	4086	7	shock	shock	NN
cord-015021-pol2qm74	4086	8	and	and	CC
cord-015021-pol2qm74	4086	9	severe	severe	JJ
cord-015021-pol2qm74	4086	10	injury	injury	NN
cord-015021-pol2qm74	4086	11	result	result	NN
cord-015021-pol2qm74	4086	12	in	in	IN
cord-015021-pol2qm74	4086	13	an	an	DT
cord-015021-pol2qm74	4086	14	increased	increase	VBN
cord-015021-pol2qm74	4086	15	release	release	NN
cord-015021-pol2qm74	4086	16	of	of	IN
cord-015021-pol2qm74	4086	17	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	4086	18	cytokines	cytokine	NNS
cord-015021-pol2qm74	4086	19	with	with	IN
cord-015021-pol2qm74	4086	20	a	a	DT
cord-015021-pol2qm74	4086	21	high	high	JJ
cord-015021-pol2qm74	4086	22	incidence	incidence	NN
cord-015021-pol2qm74	4086	23	of	of	IN
cord-015021-pol2qm74	4086	24	SIRS	SIRS	NNP
cord-015021-pol2qm74	4086	25	and	and	CC
cord-015021-pol2qm74	4086	26	MODS	mod	NNS
cord-015021-pol2qm74	4086	27	.	.	.
cord-015021-pol2qm74	4087	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	4087	2	studies	study	NNS
cord-015021-pol2qm74	4087	3	investigating	investigate	VBG
cord-015021-pol2qm74	4087	4	plasma	plasma	NN
cord-015021-pol2qm74	4087	5	levels	level	NNS
cord-015021-pol2qm74	4087	6	of	of	IN
cord-015021-pol2qm74	4087	7	anti	anti	JJ
cord-015021-pol2qm74	4087	8	-	-	JJ
cord-015021-pol2qm74	4087	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4087	10	mediators	mediator	NNS
cord-015021-pol2qm74	4087	11	(	(	-LRB-
cord-015021-pol2qm74	4087	12	IL-4	IL-4	NNP
cord-015021-pol2qm74	4087	13	,	,	,
cord-015021-pol2qm74	4087	14	IL	IL	NNP
cord-015021-pol2qm74	4087	15	-	-	HYPH
cord-015021-pol2qm74	4087	16	lra	lra	NNP
cord-015021-pol2qm74	4087	17	,	,	,
cord-015021-pol2qm74	4087	18	sTNFRs	stnfrs	IN
cord-015021-pol2qm74	4087	19	)	)	-RRB-
cord-015021-pol2qm74	4087	20	in	in	IN
cord-015021-pol2qm74	4087	21	patients	patient	NNS
cord-015021-pol2qm74	4087	22	after	after	IN
cord-015021-pol2qm74	4087	23	severe	severe	JJ
cord-015021-pol2qm74	4087	24	injury	injury	NN
cord-015021-pol2qm74	4087	25	further	further	RB
cord-015021-pol2qm74	4087	26	suggest	suggest	VBP
cord-015021-pol2qm74	4087	27	that	that	IN
cord-015021-pol2qm74	4087	28	shock	shock	NN
cord-015021-pol2qm74	4087	29	and	and	CC
cord-015021-pol2qm74	4087	30	injury	injury	NN
cord-015021-pol2qm74	4087	31	lead	lead	NN
cord-015021-pol2qm74	4087	32	to	to	IN
cord-015021-pol2qm74	4087	33	an	an	DT
cord-015021-pol2qm74	4087	34	activation	activation	NN
cord-015021-pol2qm74	4087	35	of	of	IN
cord-015021-pol2qm74	4087	36	anti	anti	JJ
cord-015021-pol2qm74	4087	37	-	-	JJ
cord-015021-pol2qm74	4087	38	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4087	39	processes	process	NNS
cord-015021-pol2qm74	4087	40	with	with	IN
cord-015021-pol2qm74	4087	41	altered	altered	JJ
cord-015021-pol2qm74	4087	42	plasma	plasma	NN
cord-015021-pol2qm74	4087	43	levels	level	NNS
cord-015021-pol2qm74	4087	44	of	of	IN
cord-015021-pol2qm74	4087	45	these	these	DT
cord-015021-pol2qm74	4087	46	mediators	mediator	NNS
cord-015021-pol2qm74	4087	47	.	.	.
cord-015021-pol2qm74	4088	1	However	however	RB
cord-015021-pol2qm74	4088	2	,	,	,
cord-015021-pol2qm74	4088	3	while	while	IN
cord-015021-pol2qm74	4088	4	plasma	plasma	NN
cord-015021-pol2qm74	4088	5	levels	level	NNS
cord-015021-pol2qm74	4088	6	of	of	IN
cord-015021-pol2qm74	4088	7	IL-4	IL-4	NNP
cord-015021-pol2qm74	4088	8	and	and	CC
cord-015021-pol2qm74	4088	9	1L	1l	CD
cord-015021-pol2qm74	4088	10	-	-	HYPH
cord-015021-pol2qm74	4088	11	lra	lra	NNP
cord-015021-pol2qm74	4088	12	were	be	VBD
cord-015021-pol2qm74	4088	13	significantly	significantly	RB
cord-015021-pol2qm74	4088	14	increased	increase	VBN
cord-015021-pol2qm74	4088	15	in	in	IN
cord-015021-pol2qm74	4088	16	trauma	trauma	NN
cord-015021-pol2qm74	4088	17	patients	patient	NNS
cord-015021-pol2qm74	4088	18	compared	compare	VBN
cord-015021-pol2qm74	4088	19	to	to	IN
cord-015021-pol2qm74	4088	20	healthy	healthy	JJ
cord-015021-pol2qm74	4088	21	volunteers	volunteer	NNS
cord-015021-pol2qm74	4088	22	,	,	,
cord-015021-pol2qm74	4088	23	sTNFRs	sTNFRs	NNP
cord-015021-pol2qm74	4088	24	did	do	VBD
cord-015021-pol2qm74	4088	25	not	not	RB
cord-015021-pol2qm74	4088	26	differ	differ	VB
cord-015021-pol2qm74	4088	27	from	from	IN
cord-015021-pol2qm74	4088	28	control	control	NN
cord-015021-pol2qm74	4088	29	samples	sample	NNS
cord-015021-pol2qm74	4088	30	.	.	.
cord-015021-pol2qm74	4089	1	Thus	thus	RB
cord-015021-pol2qm74	4089	2	,	,	,
cord-015021-pol2qm74	4089	3	shock	shock	NN
cord-015021-pol2qm74	4089	4	and	and	CC
cord-015021-pol2qm74	4089	5	severe	severe	JJ
cord-015021-pol2qm74	4089	6	injury	injury	NN
cord-015021-pol2qm74	4089	7	result	result	NN
cord-015021-pol2qm74	4089	8	in	in	IN
cord-015021-pol2qm74	4089	9	different	different	JJ
cord-015021-pol2qm74	4089	10	activation	activation	NN
cord-015021-pol2qm74	4089	11	patterns	pattern	NNS
cord-015021-pol2qm74	4089	12	of	of	IN
cord-015021-pol2qm74	4089	13	anti	anti	JJ
cord-015021-pol2qm74	4089	14	-	-	JJ
cord-015021-pol2qm74	4089	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4089	16	processes	process	NNS
cord-015021-pol2qm74	4089	17	.	.	.
cord-015021-pol2qm74	4090	1	M	M	NNP
cord-015021-pol2qm74	4090	2	,	,	,
cord-015021-pol2qm74	4090	3	L.	L.	NNP
cord-015021-pol2qm74	4090	4	Rodrick	Rodrick	NNP
cord-015021-pol2qm74	4090	5	,	,	,
cord-015021-pol2qm74	4090	6	Boston	Boston	NNP
cord-015021-pol2qm74	4090	7	,	,	,
cord-015021-pol2qm74	4090	8	b	b	NN
cord-015021-pol2qm74	4090	9	~	~	NFP
cord-015021-pol2qm74	4090	10	USA	USA	NNP
cord-015021-pol2qm74	4091	1	Following	follow	VBG
cord-015021-pol2qm74	4091	2	severe	severe	JJ
cord-015021-pol2qm74	4091	3	thermal	thermal	JJ
cord-015021-pol2qm74	4091	4	injury	injury	NN
cord-015021-pol2qm74	4091	5	significant	significant	JJ
cord-015021-pol2qm74	4091	6	suppression	suppression	NN
cord-015021-pol2qm74	4091	7	of	of	IN
cord-015021-pol2qm74	4091	8	the	the	DT
cord-015021-pol2qm74	4091	9	immune	immune	JJ
cord-015021-pol2qm74	4091	10	response	response	NN
cord-015021-pol2qm74	4091	11	has	have	VBZ
cord-015021-pol2qm74	4091	12	been	be	VBN
cord-015021-pol2qm74	4091	13	demonstrsfed	demonstrsfe	VBN
cord-015021-pol2qm74	4091	14	.	.	.
cord-015021-pol2qm74	4092	1	These	these	DT
cord-015021-pol2qm74	4092	2	changes	change	NNS
cord-015021-pol2qm74	4092	3	are	be	VBP
cord-015021-pol2qm74	4092	4	associated	associate	VBN
cord-015021-pol2qm74	4092	5	with	with	IN
cord-015021-pol2qm74	4092	6	increased	increase	VBN
cord-015021-pol2qm74	4092	7	susceptibility	susceptibility	NN
cord-015021-pol2qm74	4092	8	not	not	RB
cord-015021-pol2qm74	4092	9	only	only	RB
cord-015021-pol2qm74	4092	10	to	to	TO
cord-015021-pol2qm74	4092	11	co	co	VB
cord-015021-pol2qm74	4092	12	,	,	,
cord-015021-pol2qm74	4092	13	on	on	IN
cord-015021-pol2qm74	4092	14	human	human	JJ
cord-015021-pol2qm74	4092	15	pathogens	pathogen	NNS
cord-015021-pol2qm74	4092	16	,	,	,
cord-015021-pol2qm74	4092	17	but	but	CC
cord-015021-pol2qm74	4092	18	to	to	IN
cord-015021-pol2qm74	4092	19	organisms	organism	NNS
cord-015021-pol2qm74	4092	20	not	not	RB
cord-015021-pol2qm74	4092	21	normally	normally	RB
cord-015021-pol2qm74	4092	22	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	4092	23	in	in	IN
cord-015021-pol2qm74	4092	24	the	the	DT
cord-015021-pol2qm74	4092	25	uncompromlsed	uncompromlsed	JJ
cord-015021-pol2qm74	4092	26	host	host	NN
cord-015021-pol2qm74	4092	27	.	.	.
cord-015021-pol2qm74	4093	1	Early	early	JJ
cord-015021-pol2qm74	4093	2	observations	observation	NNS
cord-015021-pol2qm74	4093	3	included	include	VBD
cord-015021-pol2qm74	4093	4	prolonged	prolonged	JJ
cord-015021-pol2qm74	4093	5	graft	graft	NN
cord-015021-pol2qm74	4093	6	rejection	rejection	NN
cord-015021-pol2qm74	4093	7	and	and	CC
cord-015021-pol2qm74	4093	8	skin	skin	NN
cord-015021-pol2qm74	4093	9	test	test	NN
cord-015021-pol2qm74	4093	10	anergy	anergy	JJ
cord-015021-pol2qm74	4093	11	in	in	IN
cord-015021-pol2qm74	4093	12	patients	patient	NNS
cord-015021-pol2qm74	4093	13	following	follow	VBG
cord-015021-pol2qm74	4093	14	burn	burn	NN
cord-015021-pol2qm74	4093	15	injury	injury	NN
cord-015021-pol2qm74	4093	16	.	.	.
cord-015021-pol2qm74	4094	1	Work	work	VB
cord-015021-pol2qm74	4094	2	from	from	IN
cord-015021-pol2qm74	4094	3	our	-PRON-	PRP$
cord-015021-pol2qm74	4094	4	laboratory	laboratory	NN
cord-015021-pol2qm74	4094	5	and	and	CC
cord-015021-pol2qm74	4094	6	that	that	DT
cord-015021-pol2qm74	4094	7	of	of	IN
cord-015021-pol2qm74	4094	8	numerous	numerous	JJ
cord-015021-pol2qm74	4094	9	others	other	NNS
cord-015021-pol2qm74	4094	10	has	have	VBZ
cord-015021-pol2qm74	4094	11	shown	show	VBN
cord-015021-pol2qm74	4094	12	that	that	IN
cord-015021-pol2qm74	4094	13	the	the	DT
cord-015021-pol2qm74	4094	14	~	~	NFP
cord-015021-pol2qm74	4094	15	e	e	NN
cord-015021-pol2qm74	4094	16	is	be	VBZ
cord-015021-pol2qm74	4094	17	a	a	DT
cord-015021-pol2qm74	4094	18	profound	profound	JJ
cord-015021-pol2qm74	4094	19	£	£	$
cord-015021-pol2qm74	4094	20	mmunoeuppresslon	mmunoeuppresslon	NN
cord-015021-pol2qm74	4094	21	following	follow	VBG
cord-015021-pol2qm74	4094	22	severe	severe	JJ
cord-015021-pol2qm74	4094	23	thermal	thermal	JJ
cord-015021-pol2qm74	4094	24	injury	injury	NN
cord-015021-pol2qm74	4094	25	.	.	.
cord-015021-pol2qm74	4095	1	I	-PRON-	PRP
cord-015021-pol2qm74	4095	2	~	~	NFP
cord-015021-pol2qm74	4095	3	mune	mune	NNP
cord-015021-pol2qm74	4095	4	deficiency	deficiency	NN
cord-015021-pol2qm74	4095	5	has	have	VBZ
cord-015021-pol2qm74	4095	6	been	be	VBN
cord-015021-pol2qm74	4095	7	identified	identify	VBN
cord-015021-pol2qm74	4095	8	in	in	IN
cord-015021-pol2qm74	4095	9	these	these	DT
cord-015021-pol2qm74	4095	10	patients	patient	NNS
cord-015021-pol2qm74	4096	1	hyz	hyz	NNP
cord-015021-pol2qm74	4096	2	II	II	NNP
cord-015021-pol2qm74	4096	3	lack	lack	NN
cord-015021-pol2qm74	4096	4	cf	cf	NNP
cord-015021-pol2qm74	4096	5	T	T	NNP
cord-015021-pol2qm74	4096	6	nell	nell	NNP
cord-015021-pol2qm74	4096	7	responses	response	NNS
cord-015021-pol2qm74	4096	8	to	to	IN
cord-015021-pol2qm74	4096	9	mitogens	mitogens	NNP
cord-015021-pol2qm74	4096	10	,	,	,
cord-015021-pol2qm74	4096	11	2	2	CD
cord-015021-pol2qm74	4096	12	)	)	-RRB-
cord-015021-pol2qm74	4097	1	early	early	JJ
cord-015021-pol2qm74	4097	2	decreases	decrease	NNS
cord-015021-pol2qm74	4097	3	in	in	IN
cord-015021-pol2qm74	4097	4	total	total	JJ
cord-015021-pol2qm74	4097	5	T	t	NN
cord-015021-pol2qm74	4097	6	and	and	CC
cord-015021-pol2qm74	4097	7	helper	helper	NN
cord-015021-pol2qm74	4097	8	T	t	NN
cord-015021-pol2qm74	4097	9	cells	cell	NNS
cord-015021-pol2qm74	4097	10	in	in	IN
cord-015021-pol2qm74	4097	11	the	the	DT
cord-015021-pol2qm74	4097	12	peripheral	peripheral	JJ
cord-015021-pol2qm74	4097	13	bloo~	bloo~	NNP
cord-015021-pol2qm74	4097	14	3	3	CD
cord-015021-pol2qm74	4097	15	}	}	-RRB-
cord-015021-pol2qm74	4097	16	lack	lack	NN
cord-015021-pol2qm74	4097	17	of	of	IN
cord-015021-pol2qm74	4097	18	response	response	NN
cord-015021-pol2qm74	4097	19	to	to	IN
cord-015021-pol2qm74	4097	20	Tetanus	Tetanus	NNP
cord-015021-pol2qm74	4097	21	toxoid	toxoid	NN
cord-015021-pol2qm74	4098	1	i	i	PRP
cord-015021-pol2qm74	4098	2	~	~	NFP
cord-015021-pol2qm74	4098	3	uniza~	uniza~	NN
cord-015021-pol2qm74	4099	1	io~	io~	NNP
cord-015021-pol2qm74	4100	1	in	in	IN
cord-015021-pol2qm74	4100	2	spite	spite	NN
cord-015021-pol2qm74	4100	3	of	of	IN
cord-015021-pol2qm74	4100	4	increased	increase	VBN
cord-015021-pol2qm74	4100	5	non	non	JJ
cord-015021-pol2qm74	4100	6	-	-	JJ
cord-015021-pol2qm74	4100	7	speoifi~	speoifi~	JJ
cord-015021-pol2qm74	4100	8	i~	i~	ADD
cord-015021-pol2qm74	4101	1	k	k	NNP
cord-015021-pol2qm74	4101	2	~	~	NNP
cord-015021-pol2qm74	4101	3	unoglobulin	unoglobulin	NNP
cord-015021-pol2qm74	4101	4	praduction	praduction	NNP
cord-015021-pol2qm74	4101	5	and	and	CC
cord-015021-pol2qm74	4101	6	4	4	LS
cord-015021-pol2qm74	4101	7	)	)	-RRB-
cord-015021-pol2qm74	4101	8	severe	severe	JJ
cord-015021-pol2qm74	4101	9	and	and	CC
cord-015021-pol2qm74	4101	10	prolongei	prolongei	NN
cord-015021-pol2qm74	4101	11	deficiency	deficiency	NN
cord-015021-pol2qm74	4101	12	of	of	IN
cord-015021-pol2qm74	4101	13	Interleukin-2	Interleukin-2	NNP
cord-015021-pol2qm74	4101	14	(	(	-LRB-
cord-015021-pol2qm74	4101	15	IL-2	IL-2	NNP
cord-015021-pol2qm74	4101	16	)	)	-RRB-
cord-015021-pol2qm74	4101	17	prcductlon	prcductlon	NNP
cord-015021-pol2qm74	4101	18	by	by	IN
cord-015021-pol2qm74	4101	19	peripheral	peripheral	JJ
cord-015021-pol2qm74	4101	20	blood	blood	NN
cord-015021-pol2qm74	4101	21	mononuclear	mononuclear	NN
cord-015021-pol2qm74	4101	22	cells	cell	NNS
cord-015021-pol2qm74	4101	23	(	(	-LRB-
cord-015021-pol2qm74	4101	24	PBMO	PBMO	NNP
cord-015021-pol2qm74	4101	25	)	)	-RRB-
cord-015021-pol2qm74	4101	26	.	.	.
cord-015021-pol2qm74	4102	1	This	this	DT
cord-015021-pol2qm74	4102	2	IL-2	IL-2	NNP
cord-015021-pol2qm74	4102	3	deficiency	deficiency	NN
cord-015021-pol2qm74	4102	4	could	could	MD
cord-015021-pol2qm74	4102	5	be	be	VB
cord-015021-pol2qm74	4102	6	an	an	DT
cord-015021-pol2qm74	4102	7	underlyin~	underlyin~	NNP
cord-015021-pol2qm74	4102	8	cause	cause	NN
cord-015021-pol2qm74	4102	9	of	of	IN
cord-015021-pol2qm74	4102	10	all	all	PDT
cord-015021-pol2qm74	4102	11	the	the	DT
cord-015021-pol2qm74	4102	12	afo	afo	NNP
cord-015021-pol2qm74	4102	13	~	~	NFP
cord-015021-pol2qm74	4102	14	ementloned	ementloned	NNP
cord-015021-pol2qm74	4102	15	immune	immune	JJ
cord-015021-pol2qm74	4102	16	defects	defect	NNS
cord-015021-pol2qm74	4102	17	by	by	IN
cord-015021-pol2qm74	4102	18	failing	fail	VBG
cord-015021-pol2qm74	4102	19	to	to	TO
cord-015021-pol2qm74	4102	20	activate	activate	VB
cord-015021-pol2qm74	4102	21	both	both	DT
cord-015021-pol2qm74	4102	22	helper	helper	NN
cord-015021-pol2qm74	4102	23	and	and	CC
cord-015021-pol2qm74	4102	24	suppressor	suppressor	NN
cord-015021-pol2qm74	4102	25	T	T	NNP
cord-015021-pol2qm74	4102	26	cell	cell	NN
cord-015021-pol2qm74	4102	27	functions	function	NNS
cord-015021-pol2qm74	4102	28	.	.	.
cord-015021-pol2qm74	4103	1	Mo	Mo	NNP
cord-015021-pol2qm74	4103	2	~	~	NFP
cord-015021-pol2qm74	4103	3	a	a	DT
cord-015021-pol2qm74	4103	4	recent	recent	JJ
cord-015021-pol2qm74	4103	5	work	work	NN
cord-015021-pol2qm74	4103	6	has	have	VBZ
cord-015021-pol2qm74	4103	7	focused	focus	VBN
cord-015021-pol2qm74	4103	8	on	on	IN
cord-015021-pol2qm74	4103	9	the	the	DT
cord-015021-pol2qm74	4103	10	molecular	molecular	JJ
cord-015021-pol2qm74	4103	11	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4103	12	of	of	IN
cord-015021-pol2qm74	4103	13	this	this	DT
cord-015021-pol2qm74	4103	14	IL-2	IL-2	NNP
cord-015021-pol2qm74	4103	15	deficiency	deficiency	NN
cord-015021-pol2qm74	4103	16	end	end	NN
cord-015021-pol2qm74	4103	17	shown	show	VBN
cord-015021-pol2qm74	4103	18	that	that	IN
cord-015021-pol2qm74	4103	19	the	the	DT
cord-015021-pol2qm74	4103	20	defect	defect	NN
cord-015021-pol2qm74	4103	21	lies	lie	VBZ
cord-015021-pol2qm74	4103	22	post	post	VB
cord-015021-pol2qm74	4103	23	-	-	NN
cord-015021-pol2qm74	4103	24	transcrlptionally	transcrlptionally	RB
cord-015021-pol2qm74	4103	25	since	since	IN
cord-015021-pol2qm74	4103	26	mRNA	mrna	NN
cord-015021-pol2qm74	4103	27	for	for	IN
cord-015021-pol2qm74	4103	28	IL-2	IL-2	NNP
cord-015021-pol2qm74	4103	29	is	be	VBZ
cord-015021-pol2qm74	4103	30	also	also	RB
cord-015021-pol2qm74	4103	31	depressed	depressed	JJ
cord-015021-pol2qm74	4103	32	following	follow	VBG
cord-015021-pol2qm74	4103	33	thermal	thermal	JJ
cord-015021-pol2qm74	4103	34	injury	injury	NN
cord-015021-pol2qm74	4103	35	.	.	.
cord-015021-pol2qm74	4104	1	We	-PRON-	PRP
cord-015021-pol2qm74	4104	2	have	have	VBP
cord-015021-pol2qm74	4104	3	also	also	RB
cord-015021-pol2qm74	4104	4	investigated	investigate	VBN
cord-015021-pol2qm74	4104	5	the	the	DT
cord-015021-pol2qm74	4104	6	potential	potential	NN
cord-015021-pol2qm74	4104	7	of	of	IN
cord-015021-pol2qm74	4104	8	a	a	DT
cord-015021-pol2qm74	4104	9	defect	defect	NN
cord-015021-pol2qm74	4104	10	in	in	IN
cord-015021-pol2qm74	4104	11	Ii-2	Ii-2	NNP
cord-015021-pol2qm74	4104	12	receptor	receptor	NN
cord-015021-pol2qm74	4104	13	status	status	NN
cord-015021-pol2qm74	4104	14	on	on	IN
cord-015021-pol2qm74	4104	15	peripheral	peripheral	JJ
cord-015021-pol2qm74	4104	16	blood	blood	NN
cord-015021-pol2qm74	4104	17	mononuclear	mononuclear	NN
cord-015021-pol2qm74	4104	18	uolls	uoll	NNS
cord-015021-pol2qm74	4104	19	from	from	IN
cord-015021-pol2qm74	4104	20	patients	patient	NNS
cord-015021-pol2qm74	4104	21	fQllowing	fQllowing	NNP
cord-015021-pol2qm74	4104	22	burn	burn	VBP
cord-015021-pol2qm74	4104	23	injury	injury	NN
cord-015021-pol2qm74	4104	24	and	and	CC
cord-015021-pol2qm74	4104	25	in	in	IN
cord-015021-pol2qm74	4104	26	a	a	DT
cord-015021-pol2qm74	4104	27	murine	murine	JJ
cord-015021-pol2qm74	4104	28	model	model	NN
cord-015021-pol2qm74	4104	29	.	.	.
cord-015021-pol2qm74	4105	1	In	in	IN
cord-015021-pol2qm74	4105	2	both	both	DT
cord-015021-pol2qm74	4105	3	oases	oasis	NNS
cord-015021-pol2qm74	4105	4	no	no	DT
cord-015021-pol2qm74	4105	5	decrease	decrease	NN
cord-015021-pol2qm74	4105	6	in	in	IN
cord-015021-pol2qm74	4105	7	IL-2R	IL-2R	NNP
cord-015021-pol2qm74	4105	8	was	be	VBD
cord-015021-pol2qm74	4105	9	found	find	VBN
cord-015021-pol2qm74	4105	10	either	either	CC
cord-015021-pol2qm74	4105	11	by	by	IN
cord-015021-pol2qm74	4105	12	phenotypic	phenotypic	JJ
cord-015021-pol2qm74	4105	13	markers	marker	NNS
cord-015021-pol2qm74	4105	14	or	or	CC
cord-015021-pol2qm74	4105	15	by	by	IN
cord-015021-pol2qm74	4105	16	funational	funational	JJ
cord-015021-pol2qm74	4105	17	assays	assay	NNS
cord-015021-pol2qm74	4105	18	.	.	.
cord-015021-pol2qm74	4106	1	Another	another	DT
cord-015021-pol2qm74	4106	2	hallmark	hallmark	NN
cord-015021-pol2qm74	4106	3	of	of	IN
cord-015021-pol2qm74	4106	4	thermal	thermal	JJ
cord-015021-pol2qm74	4106	5	injury	injury	NN
cord-015021-pol2qm74	4106	6	is	be	VBZ
cord-015021-pol2qm74	4106	7	hyperao	hyperao	NNP
cord-015021-pol2qm74	4106	8	~	~	NFP
cord-015021-pol2qm74	4106	9	ivatlon	ivatlon	NNP
cord-015021-pol2qm74	4106	10	of	of	IN
cord-015021-pol2qm74	4106	11	proinflammatory	proinflammatory	NNP
cord-015021-pol2qm74	4107	1	~ytok	~ytok	NNP
cord-015021-pol2qm74	4108	1	~ne	~ne	NNP
cord-015021-pol2qm74	4108	2	secretion	secretion	NN
cord-015021-pol2qm74	4108	3	,	,	,
cord-015021-pol2qm74	4108	4	which	which	WDT
cord-015021-pol2qm74	4108	5	may	may	MD
cord-015021-pol2qm74	4108	6	play	play	VB
cord-015021-pol2qm74	4108	7	a	a	DT
cord-015021-pol2qm74	4108	8	significant	significant	JJ
cord-015021-pol2qm74	4108	9	role	role	NN
cord-015021-pol2qm74	4108	10	in	in	IN
cord-015021-pol2qm74	4108	11	multiple	multiple	JJ
cord-015021-pol2qm74	4108	12	organ	organ	NN
cord-015021-pol2qm74	4108	13	failure	failure	NN
cord-015021-pol2qm74	4108	14	following	follow	VBG
cord-015021-pol2qm74	4108	15	burn	burn	NN
cord-015021-pol2qm74	4108	16	injury	injury	NN
cord-015021-pol2qm74	4108	17	.	.	.
cord-015021-pol2qm74	4109	1	Therapy	therapy	NN
cord-015021-pol2qm74	4109	2	O~	O~	VBN
cord-015021-pol2qm74	4109	3	major	major	JJ
cord-015021-pol2qm74	4109	4	burn	burn	NN
cord-015021-pol2qm74	4109	5	injury	injury	NN
cord-015021-pol2qm74	4109	6	may	may	MD
cord-015021-pol2qm74	4109	7	reasonably	reasonably	RB
cord-015021-pol2qm74	4109	8	be	be	VB
cord-015021-pol2qm74	4109	9	aimed	aim	VBN
cord-015021-pol2qm74	4109	10	,	,	,
cord-015021-pol2qm74	4109	11	therefore	therefore	RB
cord-015021-pol2qm74	4109	12	,	,	,
cord-015021-pol2qm74	4109	13	at	at	IN
cord-015021-pol2qm74	4109	14	up	up	RB
cord-015021-pol2qm74	4109	15	-	-	HYPH
cord-015021-pol2qm74	4109	16	regulating	regulate	VBG
cord-015021-pol2qm74	4109	17	T	t	NN
cord-015021-pol2qm74	4109	18	cell	cell	NN
cord-015021-pol2qm74	4109	19	~unction	~unction	NNP
cord-015021-pol2qm74	4109	20	and	and	CC
cord-015021-pol2qm74	4109	21	down	down	RB
cord-015021-pol2qm74	4109	22	-	-	HYPH
cord-015021-pol2qm74	4109	23	regulating	regulate	VBG
cord-015021-pol2qm74	4109	24	hyperactive	hyperactive	JJ
cord-015021-pol2qm74	4109	25	secretion	secretion	NN
cord-015021-pol2qm74	4109	26	Of	of	IN
cord-015021-pol2qm74	4109	27	proieflaam	proieflaam	RB
cord-015021-pol2qm74	4110	1	~ntory	~ntory	JJ
cord-015021-pol2qm74	4110	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	4110	3	.	.	.
cord-015021-pol2qm74	4111	1	The	the	DT
cord-015021-pol2qm74	4111	2	majority	majority	NN
cord-015021-pol2qm74	4111	3	of	of	IN
cord-015021-pol2qm74	4111	4	patients	patient	NNS
cord-015021-pol2qm74	4111	5	dying	die	VBG
cord-015021-pol2qm74	4111	6	of	of	IN
cord-015021-pol2qm74	4111	7	bums	bum	NNS
cord-015021-pol2qm74	4111	8	succumb	succumb	VBP
cord-015021-pol2qm74	4111	9	to	to	IN
cord-015021-pol2qm74	4111	10	sepsis	sepsis	NN
cord-015021-pol2qm74	4111	11	which	which	WDT
cord-015021-pol2qm74	4111	12	coincides	coincide	VBZ
cord-015021-pol2qm74	4111	13	with	with	IN
cord-015021-pol2qm74	4111	14	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4111	15	in	in	IN
cord-015021-pol2qm74	4111	16	the	the	DT
cord-015021-pol2qm74	4111	17	specific	specific	JJ
cord-015021-pol2qm74	4111	18	and	and	CC
cord-015021-pol2qm74	4111	19	non	non	JJ
cord-015021-pol2qm74	4111	20	-	-	JJ
cord-015021-pol2qm74	4111	21	specific	specific	JJ
cord-015021-pol2qm74	4111	22	host	host	NN
cord-015021-pol2qm74	4111	23	defences	defence	NNS
cord-015021-pol2qm74	4111	24	.	.	.
cord-015021-pol2qm74	4112	1	Generally	generally	RB
cord-015021-pol2qm74	4112	2	,	,	,
cord-015021-pol2qm74	4112	3	concepts	concept	NNS
cord-015021-pol2qm74	4112	4	relating	relate	VBG
cord-015021-pol2qm74	4112	5	to	to	IN
cord-015021-pol2qm74	4112	6	the	the	DT
cord-015021-pol2qm74	4112	7	mechanism(s	mechanism(s	NNP
cord-015021-pol2qm74	4112	8	)	)	-RRB-
cord-015021-pol2qm74	4112	9	of	of	IN
cord-015021-pol2qm74	4112	10	specific	specific	JJ
cord-015021-pol2qm74	4112	11	immune	immune	JJ
cord-015021-pol2qm74	4112	12	failure	failure	NN
cord-015021-pol2qm74	4112	13	in	in	IN
cord-015021-pol2qm74	4112	14	thermal	thermal	JJ
cord-015021-pol2qm74	4112	15	trauma	trauma	NN
cord-015021-pol2qm74	4112	16	imply	imply	VBP
cord-015021-pol2qm74	4112	17	that	that	IN
cord-015021-pol2qm74	4112	18	inhibition	inhibition	NN
cord-015021-pol2qm74	4112	19	of	of	IN
cord-015021-pol2qm74	4112	20	T	T	NNP
cord-015021-pol2qm74	4112	21	(	(	-LRB-
cord-015021-pol2qm74	4112	22	CD4	CD4	NNP
cord-015021-pol2qm74	4112	23	+	+	CC
cord-015021-pol2qm74	4112	24	)	)	-RRB-
cord-015021-pol2qm74	4112	25	cell	cell	NN
cord-015021-pol2qm74	4112	26	responses	response	NNS
cord-015021-pol2qm74	4112	27	is	be	VBZ
cord-015021-pol2qm74	4112	28	imposed	impose	VBN
cord-015021-pol2qm74	4112	29	by	by	IN
cord-015021-pol2qm74	4112	30	the	the	DT
cord-015021-pol2qm74	4112	31	injury	injury	NN
cord-015021-pol2qm74	4112	32	or	or	CC
cord-015021-pol2qm74	4112	33	infection	infection	NN
cord-015021-pol2qm74	4112	34	-	-	HYPH
cord-015021-pol2qm74	4112	35	related	relate	VBN
cord-015021-pol2qm74	4112	36	factors	factor	NNS
cord-015021-pol2qm74	4112	37	.	.	.
cord-015021-pol2qm74	4113	1	However	however	RB
cord-015021-pol2qm74	4113	2	,	,	,
cord-015021-pol2qm74	4113	3	the	the	DT
cord-015021-pol2qm74	4113	4	same	same	JJ
cord-015021-pol2qm74	4113	5	factors	factor	NNS
cord-015021-pol2qm74	4113	6	elicit	elicit	VBP
cord-015021-pol2qm74	4113	7	strong	strong	JJ
cord-015021-pol2qm74	4113	8	biological	biological	JJ
cord-015021-pol2qm74	4113	9	reactions	reaction	NNS
cord-015021-pol2qm74	4113	10	within	within	IN
cord-015021-pol2qm74	4113	11	the	the	DT
cord-015021-pol2qm74	4113	12	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	4113	13	compartment	compartment	NN
cord-015021-pol2qm74	4113	14	.	.	.
cord-015021-pol2qm74	4114	1	Recent	recent	JJ
cord-015021-pol2qm74	4114	2	evidence	evidence	NN
cord-015021-pol2qm74	4114	3	indicates	indicate	VBZ
cord-015021-pol2qm74	4114	4	that	that	IN
cord-015021-pol2qm74	4114	5	systemic	systemic	JJ
cord-015021-pol2qm74	4114	6	activation	activation	NN
cord-015021-pol2qm74	4114	7	is	be	VBZ
cord-015021-pol2qm74	4114	8	inherent	inherent	JJ
cord-015021-pol2qm74	4114	9	in	in	IN
cord-015021-pol2qm74	4114	10	the	the	DT
cord-015021-pol2qm74	4114	11	burn	burn	NN
cord-015021-pol2qm74	4114	12	patient	patient	NN
cord-015021-pol2qm74	4114	13	.	.	.
cord-015021-pol2qm74	4115	1	To	to	TO
cord-015021-pol2qm74	4115	2	establish	establish	VB
cord-015021-pol2qm74	4115	3	the	the	DT
cord-015021-pol2qm74	4115	4	relation	relation	NN
cord-015021-pol2qm74	4115	5	of	of	IN
cord-015021-pol2qm74	4115	6	molecular	molecular	JJ
cord-015021-pol2qm74	4115	7	and	and	CC
cord-015021-pol2qm74	4115	8	cellular	cellular	JJ
cord-015021-pol2qm74	4115	9	events	event	NNS
cord-015021-pol2qm74	4115	10	to	to	IN
cord-015021-pol2qm74	4115	11	the	the	DT
cord-015021-pol2qm74	4115	12	development	development	NN
cord-015021-pol2qm74	4115	13	of	of	IN
cord-015021-pol2qm74	4115	14	post	post	JJ
cord-015021-pol2qm74	4115	15	-	-	JJ
cord-015021-pol2qm74	4115	16	bum	bum	JJ
cord-015021-pol2qm74	4115	17	anergy	anergy	NNP
cord-015021-pol2qm74	4115	18	we	-PRON-	PRP
cord-015021-pol2qm74	4115	19	examined	examine	VBD
cord-015021-pol2qm74	4115	20	the	the	DT
cord-015021-pol2qm74	4115	21	state	state	NN
cord-015021-pol2qm74	4115	22	of	of	IN
cord-015021-pol2qm74	4115	23	and	and	CC
cord-015021-pol2qm74	4115	24	the	the	DT
cord-015021-pol2qm74	4115	25	capacity	capacity	NN
cord-015021-pol2qm74	4115	26	for	for	IN
cord-015021-pol2qm74	4115	27	T	T	NNP
cord-015021-pol2qm74	4115	28	cell	cell	NN
cord-015021-pol2qm74	4115	29	activation	activation	NN
cord-015021-pol2qm74	4115	30	with	with	IN
cord-015021-pol2qm74	4115	31	regard	regard	NN
cord-015021-pol2qm74	4115	32	to	to	IN
cord-015021-pol2qm74	4115	33	:	:	:
cord-015021-pol2qm74	4115	34	1	1	LS
cord-015021-pol2qm74	4115	35	)	)	-RRB-
cord-015021-pol2qm74	4115	36	occurrence	occurrence	NN
cord-015021-pol2qm74	4115	37	of	of	IN
cord-015021-pol2qm74	4115	38	activation	activation	NN
cord-015021-pol2qm74	4115	39	-	-	HYPH
cord-015021-pol2qm74	4115	40	induced	induce	VBN
cord-015021-pol2qm74	4115	41	cell	cell	NN
cord-015021-pol2qm74	4115	42	death	death	NN
cord-015021-pol2qm74	4115	43	(	(	-LRB-
cord-015021-pol2qm74	4115	44	AICD	AICD	NNP
cord-015021-pol2qm74	4115	45	)	)	-RRB-
cord-015021-pol2qm74	4115	46	,	,	,
cord-015021-pol2qm74	4115	47	2	2	CD
cord-015021-pol2qm74	4115	48	)	)	-RRB-
cord-015021-pol2qm74	4115	49	activation	activation	NN
cord-015021-pol2qm74	4115	50	-	-	HYPH
cord-015021-pol2qm74	4115	51	related	relate	VBN
cord-015021-pol2qm74	4115	52	phenotypic	phenotypic	NN
cord-015021-pol2qm74	4115	53	and	and	CC
cord-015021-pol2qm74	4115	54	functional	functional	JJ
cord-015021-pol2qm74	4115	55	_	_	NN
cord-015021-pol2qm74	4115	56	diversity	diversity	NN
cord-015021-pol2qm74	4115	57	in	in	IN
cord-015021-pol2qm74	4115	58	the	the	DT
cord-015021-pol2qm74	4115	59	pool	pool	NN
cord-015021-pol2qm74	4115	60	of	of	IN
cord-015021-pol2qm74	4115	61	peripheral	peripheral	JJ
cord-015021-pol2qm74	4115	62	CD4	CD4	NNP
cord-015021-pol2qm74	4115	63	+	+	CC
cord-015021-pol2qm74	4115	64	T	t	NN
cord-015021-pol2qm74	4115	65	cells	cell	NNS
cord-015021-pol2qm74	4115	66	.	.	.
cord-015021-pol2qm74	4116	1	Initially	initially	RB
cord-015021-pol2qm74	4116	2	,	,	,
cord-015021-pol2qm74	4116	3	(	(	-LRB-
cord-015021-pol2qm74	4116	4	up	up	IN
cord-015021-pol2qm74	4116	5	to	to	TO
cord-015021-pol2qm74	4116	6	7	7	CD
cord-015021-pol2qm74	4116	7	days	day	NNS
cord-015021-pol2qm74	4116	8	post	post	JJ
cord-015021-pol2qm74	4116	9	-	-	JJ
cord-015021-pol2qm74	4116	10	bum	bum	JJ
cord-015021-pol2qm74	4116	11	)	)	-RRB-
cord-015021-pol2qm74	4116	12	,	,	,
cord-015021-pol2qm74	4116	13	peripheral	peripheral	JJ
cord-015021-pol2qm74	4116	14	blood	blood	NN
cord-015021-pol2qm74	4116	15	lympliocytes	lympliocyte	NNS
cord-015021-pol2qm74	4116	16	from	from	IN
cord-015021-pol2qm74	4116	17	severely	severely	RB
cord-015021-pol2qm74	4116	18	injured	injure	VBN
cord-015021-pol2qm74	4116	19	(	(	-LRB-
cord-015021-pol2qm74	4116	20	>	>	NFP
cord-015021-pol2qm74	4116	21	35	35	CD
cord-015021-pol2qm74	4116	22	%	%	NN
cord-015021-pol2qm74	4116	23	total	total	JJ
cord-015021-pol2qm74	4116	24	body	body	NN
cord-015021-pol2qm74	4116	25	surface	surface	NN
cord-015021-pol2qm74	4116	26	area	area	NN
cord-015021-pol2qm74	4116	27	)	)	-RRB-
cord-015021-pol2qm74	4117	1	patients	patient	NNS
cord-015021-pol2qm74	4117	2	exhibited	exhibit	VBD
cord-015021-pol2qm74	4117	3	high	high	JJ
cord-015021-pol2qm74	4117	4	levels	level	NNS
cord-015021-pol2qm74	4117	5	of	of	IN
cord-015021-pol2qm74	4117	6	constitutive	constitutive	JJ
cord-015021-pol2qm74	4117	7	expression	expression	NN
cord-015021-pol2qm74	4117	8	of	of	IN
cord-015021-pol2qm74	4117	9	surface	surface	NN
cord-015021-pol2qm74	4117	10	receptor	receptor	NN
cord-015021-pol2qm74	4117	11	for	for	IN
cord-015021-pol2qm74	4117	12	]	]	-RRB-
cord-015021-pol2qm74	4117	13	L	l	NN
cord-015021-pol2qm74	4117	14	2	2	CD
cord-015021-pol2qm74	4117	15	(	(	-LRB-
cord-015021-pol2qm74	4117	16	CD	CD	NNP
cord-015021-pol2qm74	4117	17	25	25	CD
cord-015021-pol2qm74	4117	18	)	)	-RRB-
cord-015021-pol2qm74	4117	19	and	and	CC
cord-015021-pol2qm74	4117	20	spontaneous	spontaneous	JJ
cord-015021-pol2qm74	4117	21	blastogenesis	blastogenesis	NN
cord-015021-pol2qm74	4117	22	.	.	.
cord-015021-pol2qm74	4118	1	The	the	DT
cord-015021-pol2qm74	4118	2	presence	presence	NN
cord-015021-pol2qm74	4118	3	of	of	IN
cord-015021-pol2qm74	4118	4	activation	activation	NN
cord-015021-pol2qm74	4118	5	-	-	HYPH
cord-015021-pol2qm74	4118	6	related	relate	VBN
cord-015021-pol2qm74	4118	7	T	t	NN
cord-015021-pol2qm74	4118	8	cellproducts	cellproduct	NNS
cord-015021-pol2qm74	4118	9	in	in	IN
cord-015021-pol2qm74	4118	10	bum	bum	NN
cord-015021-pol2qm74	4118	11	plasma	plasma	NN
cord-015021-pol2qm74	4118	12	was	be	VBD
cord-015021-pol2qm74	4118	13	also	also	RB
cord-015021-pol2qm74	4118	14	apparent	apparent	JJ
cord-015021-pol2qm74	4118	15	.	.	.
cord-015021-pol2qm74	4119	1	Subsequent	subsequent	JJ
cord-015021-pol2qm74	4119	2	impairment	impairment	NN
cord-015021-pol2qm74	4119	3	of	of	IN
cord-015021-pol2qm74	4119	4	the	the	DT
cord-015021-pol2qm74	4119	5	T	T	NNP
cord-015021-pol2qm74	4119	6	cell	cell	NN
cord-015021-pol2qm74	4119	7	receptor	receptor	NN
cord-015021-pol2qm74	4119	8	(	(	-LRB-
cord-015021-pol2qm74	4119	9	TCR)-regulated	tcr)-regulate	VBN
cord-015021-pol2qm74	4119	10	T	T	NNP
cord-015021-pol2qm74	4119	11	cell	cell	NN
cord-015021-pol2qm74	4119	12	responses	response	NNS
cord-015021-pol2qm74	4119	13	in	in	IN
cord-015021-pol2qm74	4119	14	vitro	vitro	FW
cord-015021-pol2qm74	4119	15	was	be	VBD
cord-015021-pol2qm74	4119	16	accompanied	accompany	VBN
cord-015021-pol2qm74	4119	17	by	by	IN
cord-015021-pol2qm74	4119	18	significantly	significantly	RB
cord-015021-pol2qm74	4119	19	increased	increase	VBN
cord-015021-pol2qm74	4119	20	DNA	dna	NN
cord-015021-pol2qm74	4119	21	fragmentation	fragmentation	NN
cord-015021-pol2qm74	4119	22	that	that	WDT
cord-015021-pol2qm74	4119	23	is	be	VBZ
cord-015021-pol2qm74	4119	24	associated	associate	VBN
cord-015021-pol2qm74	4119	25	with	with	IN
cord-015021-pol2qm74	4119	26	cell	cell	NN
cord-015021-pol2qm74	4119	27	death	death	NN
cord-015021-pol2qm74	4119	28	by	by	IN
cord-015021-pol2qm74	4119	29	the	the	DT
cord-015021-pol2qm74	4119	30	mode	mode	NN
cord-015021-pol2qm74	4119	31	of	of	IN
cord-015021-pol2qm74	4119	32	apoptosis	apoptosis	NN
cord-015021-pol2qm74	4119	33	.	.	.
cord-015021-pol2qm74	4120	1	Using	use	VBG
cord-015021-pol2qm74	4120	2	molecular	molecular	JJ
cord-015021-pol2qm74	4120	3	markers	marker	NNS
cord-015021-pol2qm74	4120	4	we	-PRON-	PRP
cord-015021-pol2qm74	4120	5	established	establish	VBD
cord-015021-pol2qm74	4120	6	that	that	IN
cord-015021-pol2qm74	4120	7	flesh	flesh	NN
cord-015021-pol2qm74	4120	8	peripheral	peripheral	JJ
cord-015021-pol2qm74	4120	9	blood	blood	NN
cord-015021-pol2qm74	4120	10	ceils	ceil	NNS
cord-015021-pol2qm74	4120	11	from	from	IN
cord-015021-pol2qm74	4120	12	immunosuppressed	immunosuppressed	JJ
cord-015021-pol2qm74	4120	13	patients	patient	NNS
cord-015021-pol2qm74	4120	14	also	also	RB
cord-015021-pol2qm74	4120	15	contain	contain	VBP
cord-015021-pol2qm74	4120	16	large	large	JJ
cord-015021-pol2qm74	4120	17	numbers	number	NNS
cord-015021-pol2qm74	4120	18	of	of	IN
cord-015021-pol2qm74	4120	19	apoptotic	apoptotic	JJ
cord-015021-pol2qm74	4120	20	cells	cell	NNS
cord-015021-pol2qm74	4120	21	.	.	.
cord-015021-pol2qm74	4121	1	Fluctuations	fluctuation	NNS
cord-015021-pol2qm74	4121	2	in	in	IN
cord-015021-pol2qm74	4121	3	the	the	DT
cord-015021-pol2qm74	4121	4	number	number	NN
cord-015021-pol2qm74	4121	5	of	of	IN
cord-015021-pol2qm74	4121	6	viable	viable	JJ
cord-015021-pol2qm74	4121	7	(	(	-LRB-
cord-015021-pol2qm74	4121	8	PI-	PI-	NNP
cord-015021-pol2qm74	4121	9	)	)	-RRB-
cord-015021-pol2qm74	4121	10	peripheral	peripheral	JJ
cord-015021-pol2qm74	4121	11	blood	blood	NN
cord-015021-pol2qm74	4121	12	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4121	13	involved	involve	VBN
cord-015021-pol2qm74	4121	14	primarily	primarily	RB
cord-015021-pol2qm74	4121	15	CD4+/CD45RO+	CD4+/CD45RO+	NNP
cord-015021-pol2qm74	4121	16	(	(	-LRB-
cord-015021-pol2qm74	4121	17	memory	memory	NN
cord-015021-pol2qm74	4121	18	)	)	-RRB-
cord-015021-pol2qm74	4121	19	subset	subset	NN
cord-015021-pol2qm74	4121	20	of	of	IN
cord-015021-pol2qm74	4121	21	T	T	NNP
cord-015021-pol2qm74	4121	22	ceils	ceil	NNS
cord-015021-pol2qm74	4121	23	.	.	.
cord-015021-pol2qm74	4122	1	The	the	DT
cord-015021-pol2qm74	4122	2	above	above	JJ
cord-015021-pol2qm74	4122	3	observations	observation	NNS
cord-015021-pol2qm74	4122	4	suggest	suggest	VBP
cord-015021-pol2qm74	4122	5	that	that	IN
cord-015021-pol2qm74	4122	6	thermal	thermal	JJ
cord-015021-pol2qm74	4122	7	trauma	trauma	NN
cord-015021-pol2qm74	4122	8	-	-	HYPH
cord-015021-pol2qm74	4122	9	associated	associate	VBN
cord-015021-pol2qm74	4122	10	T	T	NNP
cord-015021-pol2qm74	4122	11	cell	cell	NN
cord-015021-pol2qm74	4122	12	anergy	anergy	NN
cord-015021-pol2qm74	4122	13	develops	develop	VBZ
cord-015021-pol2qm74	4122	14	through	through	IN
cord-015021-pol2qm74	4122	15	AICD	AICD	NNP
cord-015021-pol2qm74	4122	16	,	,	,
cord-015021-pol2qm74	4122	17	a	a	DT
cord-015021-pol2qm74	4122	18	phenomenon	phenomenon	NN
cord-015021-pol2qm74	4122	19	commonly	commonly	RB
cord-015021-pol2qm74	4122	20	associated	associate	VBN
cord-015021-pol2qm74	4122	21	with	with	IN
cord-015021-pol2qm74	4122	22	the	the	DT
cord-015021-pol2qm74	4122	23	tolerogenic	tolerogenic	JJ
cord-015021-pol2qm74	4122	24	activity	activity	NN
cord-015021-pol2qm74	4122	25	of	of	IN
cord-015021-pol2qm74	4122	26	bacterial	bacterial	JJ
cord-015021-pol2qm74	4122	27	superantigens	superantigen	NNS
cord-015021-pol2qm74	4122	28	.	.	.
cord-015021-pol2qm74	4123	1	Persistence	persistence	NN
cord-015021-pol2qm74	4123	2	of	of	IN
cord-015021-pol2qm74	4123	3	staphylococcal	staphylococcal	JJ
cord-015021-pol2qm74	4123	4	infections	infection	NNS
cord-015021-pol2qm74	4123	5	in	in	IN
cord-015021-pol2qm74	4123	6	the	the	DT
cord-015021-pol2qm74	4123	7	burn	burn	NN
cord-015021-pol2qm74	4123	8	patient	patient	NN
cord-015021-pol2qm74	4123	9	may	may	MD
cord-015021-pol2qm74	4123	10	support	support	VB
cord-015021-pol2qm74	4123	11	this	this	DT
cord-015021-pol2qm74	4123	12	assumption	assumption	NN
cord-015021-pol2qm74	4123	13	.	.	.
cord-015021-pol2qm74	4124	1	RESPONSE	response	NN
cord-015021-pol2qm74	4124	2	FOLLOWING	FOLLOWING	NNP
cord-015021-pol2qm74	4124	3	TRAUMA	trauma	NN
cord-015021-pol2qm74	4124	4	JANE	JANE	NNP
cord-015021-pol2qm74	4124	5	SHELBY	SHELBY	NNP
cord-015021-pol2qm74	4124	6	,	,	,
cord-015021-pol2qm74	4125	1	Ph.D.	Ph.D.	NNP
cord-015021-pol2qm74	4125	2	The	the	DT
cord-015021-pol2qm74	4125	3	immune	immune	JJ
cord-015021-pol2qm74	4125	4	system	system	NN
cord-015021-pol2qm74	4125	5	is	be	VBZ
cord-015021-pol2qm74	4125	6	integrated	integrate	VBN
cord-015021-pol2qm74	4125	7	with	with	IN
cord-015021-pol2qm74	4125	8	other	other	JJ
cord-015021-pol2qm74	4125	9	physiologic	physiologic	JJ
cord-015021-pol2qm74	4125	10	systems	system	NNS
cord-015021-pol2qm74	4125	11	,	,	,
cord-015021-pol2qm74	4125	12	and	and	CC
cord-015021-pol2qm74	4125	13	is	be	VBZ
cord-015021-pol2qm74	4125	14	exquisitely	exquisitely	RB
cord-015021-pol2qm74	4125	15	sensitive	sensitive	JJ
cord-015021-pol2qm74	4125	16	to	to	IN
cord-015021-pol2qm74	4125	17	changes	change	NNS
cord-015021-pol2qm74	4125	18	in	in	IN
cord-015021-pol2qm74	4125	19	nervous	nervous	JJ
cord-015021-pol2qm74	4125	20	and	and	CC
cord-015021-pol2qm74	4125	21	endocrine	endocrine	JJ
cord-015021-pol2qm74	4125	22	systems	system	NNS
cord-015021-pol2qm74	4125	23	changes	change	VBZ
cord-015021-pol2qm74	4125	24	following	follow	VBG
cord-015021-pol2qm74	4125	25	traumatic	traumatic	JJ
cord-015021-pol2qm74	4125	26	stress	stress	NN
cord-015021-pol2qm74	4125	27	challenge	challenge	NN
cord-015021-pol2qm74	4125	28	.	.	.
cord-015021-pol2qm74	4126	1	The	the	DT
cord-015021-pol2qm74	4126	2	immune	immune	JJ
cord-015021-pol2qm74	4126	3	,	,	,
cord-015021-pol2qm74	4126	4	nervous	nervous	JJ
cord-015021-pol2qm74	4126	5	and	and	CC
cord-015021-pol2qm74	4126	6	endocrine	endocrine	JJ
cord-015021-pol2qm74	4126	7	systems	system	NNS
cord-015021-pol2qm74	4126	8	interact	interact	VBP
cord-015021-pol2qm74	4126	9	via	via	IN
cord-015021-pol2qm74	4126	10	both	both	CC
cord-015021-pol2qm74	4126	11	direct	direct	JJ
cord-015021-pol2qm74	4126	12	and	and	CC
cord-015021-pol2qm74	4126	13	indirect	indirect	JJ
cord-015021-pol2qm74	4126	14	pathways	pathway	NNS
cord-015021-pol2qm74	4126	15	which	which	WDT
cord-015021-pol2qm74	4126	16	utilize	utilize	VBP
cord-015021-pol2qm74	4126	17	neuro	neuro	NNP
cord-015021-pol2qm74	4126	18	and	and	CC
cord-015021-pol2qm74	4126	19	endocrine	endocrine	JJ
cord-015021-pol2qm74	4126	20	hormones	hormone	NNS
cord-015021-pol2qm74	4126	21	,	,	,
cord-015021-pol2qm74	4126	22	neurotransmitters	neurotransmitter	NNS
cord-015021-pol2qm74	4126	23	,	,	,
cord-015021-pol2qm74	4126	24	neurepeptides	neurepeptide	NNS
cord-015021-pol2qm74	4126	25	and	and	CC
cord-015021-pol2qm74	4126	26	immune	immune	JJ
cord-015021-pol2qm74	4126	27	cell	cell	NN
cord-015021-pol2qm74	4126	28	products	product	NNS
cord-015021-pol2qm74	4126	29	.	.	.
cord-015021-pol2qm74	4127	1	It	-PRON-	PRP
cord-015021-pol2qm74	4127	2	is	be	VBZ
cord-015021-pol2qm74	4127	3	now	now	RB
cord-015021-pol2qm74	4127	4	known	know	VBN
cord-015021-pol2qm74	4127	5	that	that	IN
cord-015021-pol2qm74	4127	6	the	the	DT
cord-015021-pol2qm74	4127	7	immune	immune	JJ
cord-015021-pol2qm74	4127	8	system	system	NN
cord-015021-pol2qm74	4127	9	may	may	MD
cord-015021-pol2qm74	4127	10	be	be	VB
cord-015021-pol2qm74	4127	11	affected	affect	VBN
cord-015021-pol2qm74	4127	12	by	by	IN
cord-015021-pol2qm74	4127	13	all	all	DT
cord-015021-pol2qm74	4127	14	of	of	IN
cord-015021-pol2qm74	4127	15	the	the	DT
cord-015021-pol2qm74	4127	16	neuroendocrine	neuroendocrine	JJ
cord-015021-pol2qm74	4127	17	products	product	NNS
cord-015021-pol2qm74	4127	18	produced	produce	VBN
cord-015021-pol2qm74	4127	19	during	during	IN
cord-015021-pol2qm74	4127	20	a	a	DT
cord-015021-pol2qm74	4127	21	stress	stress	NN
cord-015021-pol2qm74	4127	22	response	response	NN
cord-015021-pol2qm74	4127	23	,	,	,
cord-015021-pol2qm74	4127	24	with	with	IN
cord-015021-pol2qm74	4127	25	evidence	evidence	NN
cord-015021-pol2qm74	4127	26	for	for	IN
cord-015021-pol2qm74	4127	27	innervation	innervation	NN
cord-015021-pol2qm74	4127	28	of	of	IN
cord-015021-pol2qm74	4127	29	iymphoid	iymphoid	NNP
cord-015021-pol2qm74	4127	30	organs	organ	NNS
cord-015021-pol2qm74	4127	31	,	,	,
cord-015021-pol2qm74	4127	32	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	4127	33	cell	cell	NN
cord-015021-pol2qm74	4127	34	receptors	receptor	NNS
cord-015021-pol2qm74	4127	35	for	for	IN
cord-015021-pol2qm74	4127	36	neuroendocdne	neuroendocdne	NNP
cord-015021-pol2qm74	4127	37	products	product	NNS
cord-015021-pol2qm74	4127	38	,	,	,
cord-015021-pol2qm74	4127	39	and	and	CC
cord-015021-pol2qm74	4127	40	leukocyte	leukocyte	NN
cord-015021-pol2qm74	4127	41	production	production	NN
cord-015021-pol2qm74	4127	42	of	of	IN
cord-015021-pol2qm74	4127	43	chemicals	chemical	NNS
cord-015021-pol2qm74	4127	44	which	which	WDT
cord-015021-pol2qm74	4127	45	are	be	VBP
cord-015021-pol2qm74	4127	46	virtually	virtually	RB
cord-015021-pol2qm74	4127	47	identical	identical	JJ
cord-015021-pol2qm74	4127	48	to	to	IN
cord-015021-pol2qm74	4127	49	certain	certain	JJ
cord-015021-pol2qm74	4127	50	neuroendocdne	neuroendocdne	NNP
cord-015021-pol2qm74	4127	51	peptides	peptide	NNS
cord-015021-pol2qm74	4127	52	(	(	-LRB-
cord-015021-pol2qm74	4127	53	ACTH	ACTH	NNP
cord-015021-pol2qm74	4127	54	,	,	,
cord-015021-pol2qm74	4127	55	endorphins	endorphin	NNS
cord-015021-pol2qm74	4127	56	)	)	-RRB-
cord-015021-pol2qm74	4127	57	.	.	.
cord-015021-pol2qm74	4128	1	Trauma	trauma	NN
cord-015021-pol2qm74	4128	2	induced	induce	VBN
cord-015021-pol2qm74	4128	3	alterations	alteration	NNS
cord-015021-pol2qm74	4128	4	in	in	IN
cord-015021-pol2qm74	4128	5	the	the	DT
cord-015021-pol2qm74	4128	6	equilibrium	equilibrium	NN
cord-015021-pol2qm74	4128	7	of	of	IN
cord-015021-pol2qm74	4128	8	various	various	JJ
cord-015021-pol2qm74	4128	9	neuropeptides	neuropeptide	NNS
cord-015021-pol2qm74	4128	10	and	and	CC
cord-015021-pol2qm74	4128	11	neuroendocdne	neuroendocdne	NNP
cord-015021-pol2qm74	4128	12	hormones	hormone	NNS
cord-015021-pol2qm74	4128	13	have	have	VBP
cord-015021-pol2qm74	4128	14	a	a	DT
cord-015021-pol2qm74	4128	15	significant	significant	JJ
cord-015021-pol2qm74	4128	16	impact	impact	NN
cord-015021-pol2qm74	4128	17	on	on	IN
cord-015021-pol2qm74	4128	18	immune	immune	JJ
cord-015021-pol2qm74	4128	19	response	response	NN
cord-015021-pol2qm74	4128	20	potential	potential	NN
cord-015021-pol2qm74	4128	21	,	,	,
cord-015021-pol2qm74	4128	22	affecting	affect	VBG
cord-015021-pol2qm74	4128	23	control	control	NN
cord-015021-pol2qm74	4128	24	of	of	IN
cord-015021-pol2qm74	4128	25	proliferation	proliferation	NN
cord-015021-pol2qm74	4128	26	,	,	,
cord-015021-pol2qm74	4128	27	differentiation	differentiation	NN
cord-015021-pol2qm74	4128	28	and	and	CC
cord-015021-pol2qm74	4128	29	function	function	NN
cord-015021-pol2qm74	4128	30	of	of	IN
cord-015021-pol2qm74	4128	31	immune	immune	JJ
cord-015021-pol2qm74	4128	32	cells	cell	NNS
cord-015021-pol2qm74	4128	33	.	.	.
cord-015021-pol2qm74	4129	1	For	for	IN
cord-015021-pol2qm74	4129	2	example	example	NN
cord-015021-pol2qm74	4129	3	,	,	,
cord-015021-pol2qm74	4129	4	the	the	DT
cord-015021-pol2qm74	4129	5	neurohormone	neurohormone	NNP
cord-015021-pol2qm74	4129	6	melatonin	melatonin	NNP
cord-015021-pol2qm74	4129	7	is	be	VBZ
cord-015021-pol2qm74	4129	8	thought	think	VBN
cord-015021-pol2qm74	4129	9	to	to	TO
cord-015021-pol2qm74	4129	10	be	be	VB
cord-015021-pol2qm74	4129	11	a	a	DT
cord-015021-pol2qm74	4129	12	natural	natural	JJ
cord-015021-pol2qm74	4129	13	antagonist	antagonist	NN
cord-015021-pol2qm74	4129	14	to	to	TO
cord-015021-pol2qm74	4129	15	counteract	counteract	VB
cord-015021-pol2qm74	4129	16	glucocorticeid	glucocorticeid	NN
cord-015021-pol2qm74	4129	17	associated	associate	VBN
cord-015021-pol2qm74	4129	18	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	4129	19	resulting	result	VBG
cord-015021-pol2qm74	4129	20	from	from	IN
cord-015021-pol2qm74	4129	21	stressful	stressful	JJ
cord-015021-pol2qm74	4129	22	challenges	challenge	NNS
cord-015021-pol2qm74	4129	23	,	,	,
cord-015021-pol2qm74	4129	24	such	such	JJ
cord-015021-pol2qm74	4129	25	as	as	IN
cord-015021-pol2qm74	4129	26	surgery	surgery	NN
cord-015021-pol2qm74	4129	27	and	and	CC
cord-015021-pol2qm74	4129	28	trauma	trauma	NN
cord-015021-pol2qm74	4129	29	,	,	,
cord-015021-pol2qm74	4129	30	Plasma	plasma	NN
cord-015021-pol2qm74	4129	31	melatonin	melatonin	NN
cord-015021-pol2qm74	4129	32	levels	level	NNS
cord-015021-pol2qm74	4129	33	are	be	VBP
cord-015021-pol2qm74	4129	34	known	know	VBN
cord-015021-pol2qm74	4129	35	to	to	TO
cord-015021-pol2qm74	4129	36	be	be	VB
cord-015021-pol2qm74	4129	37	significantly	significantly	RB
cord-015021-pol2qm74	4129	38	reduced	reduce	VBN
cord-015021-pol2qm74	4129	39	in	in	IN
cord-015021-pol2qm74	4129	40	burn	burn	NN
cord-015021-pol2qm74	4129	41	patients	patient	NNS
cord-015021-pol2qm74	4129	42	.	.	.
cord-015021-pol2qm74	4130	1	The	the	DT
cord-015021-pol2qm74	4130	2	administration	administration	NN
cord-015021-pol2qm74	4130	3	of	of	IN
cord-015021-pol2qm74	4130	4	exogenous	exogenous	JJ
cord-015021-pol2qm74	4130	5	me[atonin	me[atonin	NNP
cord-015021-pol2qm74	4130	6	improved	improve	VBD
cord-015021-pol2qm74	4130	7	cellular	cellular	JJ
cord-015021-pol2qm74	4130	8	immune	immune	JJ
cord-015021-pol2qm74	4130	9	response	response	NN
cord-015021-pol2qm74	4130	10	following	follow	VBG
cord-015021-pol2qm74	4130	11	burn	burn	NN
cord-015021-pol2qm74	4130	12	injury	injury	NN
cord-015021-pol2qm74	4130	13	in	in	IN
cord-015021-pol2qm74	4130	14	an	an	DT
cord-015021-pol2qm74	4130	15	animal	animal	NN
cord-015021-pol2qm74	4130	16	model	model	NN
cord-015021-pol2qm74	4130	17	.	.	.
cord-015021-pol2qm74	4131	1	Melatonin	melatonin	NN
cord-015021-pol2qm74	4131	2	was	be	VBD
cord-015021-pol2qm74	4131	3	also	also	RB
cord-015021-pol2qm74	4131	4	shown	show	VBN
cord-015021-pol2qm74	4131	5	to	to	TO
cord-015021-pol2qm74	4131	6	have	have	VB
cord-015021-pol2qm74	4131	7	in	in	IN
cord-015021-pol2qm74	4131	8	vivo	vivo	NN
cord-015021-pol2qm74	4131	9	cytokine	cytokine	JJ
cord-015021-pol2qm74	4131	10	regulatory	regulatory	JJ
cord-015021-pol2qm74	4131	11	activity	activity	NN
cord-015021-pol2qm74	4131	12	,	,	,
cord-015021-pol2qm74	4131	13	increasing	increase	VBG
cord-015021-pol2qm74	4131	14	the	the	DT
cord-015021-pol2qm74	4131	15	potential	potential	NN
cord-015021-pol2qm74	4131	16	for	for	IN
cord-015021-pol2qm74	4131	17	IL-2	il-2	NN
cord-015021-pol2qm74	4131	18	secretion	secretion	NN
cord-015021-pol2qm74	4131	19	and	and	CC
cord-015021-pol2qm74	4131	20	downregulating	downregulate	VBG
cord-015021-pol2qm74	4131	21	excessive	excessive	JJ
cord-015021-pol2qm74	4131	22	IL-6	IL-6	NNP
cord-015021-pol2qm74	4131	23	and	and	CC
cord-015021-pol2qm74	4131	24	IFN~	IFN~	NNS
cord-015021-pol2qm74	4131	25	in	in	IN
cord-015021-pol2qm74	4131	26	burn	burn	NN
cord-015021-pol2qm74	4131	27	injured	injure	VBN
cord-015021-pol2qm74	4131	28	,	,	,
cord-015021-pol2qm74	4131	29	stress	stress	NN
cord-015021-pol2qm74	4131	30	susceptible	susceptible	JJ
cord-015021-pol2qm74	4131	31	mice	mouse	NNS
cord-015021-pol2qm74	4131	32	.	.	.
cord-015021-pol2qm74	4132	1	The	the	DT
cord-015021-pol2qm74	4132	2	regulatory	regulatory	JJ
cord-015021-pol2qm74	4132	3	interactions	interaction	NNS
cord-015021-pol2qm74	4132	4	between	between	IN
cord-015021-pol2qm74	4132	5	the	the	DT
cord-015021-pol2qm74	4132	6	immune	immune	JJ
cord-015021-pol2qm74	4132	7	,	,	,
cord-015021-pol2qm74	4132	8	nervous	nervous	JJ
cord-015021-pol2qm74	4132	9	and	and	CC
cord-015021-pol2qm74	4132	10	endocrine	endocrine	JJ
cord-015021-pol2qm74	4132	11	systems	system	NNS
cord-015021-pol2qm74	4132	12	provide	provide	VBP
cord-015021-pol2qm74	4132	13	mechanistic	mechanistic	JJ
cord-015021-pol2qm74	4132	14	pathways	pathway	NNS
cord-015021-pol2qm74	4132	15	for	for	IN
cord-015021-pol2qm74	4132	16	trauma	trauma	NN
cord-015021-pol2qm74	4132	17	associated	associate	VBD
cord-015021-pol2qm74	4132	18	immune	immune	JJ
cord-015021-pol2qm74	4132	19	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4132	20	.	.	.
cord-015021-pol2qm74	4133	1	Increased	increase	VBN
cord-015021-pol2qm74	4133	2	knowledge	knowledge	NN
cord-015021-pol2qm74	4133	3	of	of	IN
cord-015021-pol2qm74	4133	4	these	these	DT
cord-015021-pol2qm74	4133	5	interactions	interaction	NNS
cord-015021-pol2qm74	4133	6	will	will	MD
cord-015021-pol2qm74	4133	7	enhance	enhance	VB
cord-015021-pol2qm74	4133	8	the	the	DT
cord-015021-pol2qm74	4133	9	potential	potential	NN
cord-015021-pol2qm74	4133	10	for	for	IN
cord-015021-pol2qm74	4133	11	the	the	DT
cord-015021-pol2qm74	4133	12	design	design	NN
cord-015021-pol2qm74	4133	13	of	of	IN
cord-015021-pol2qm74	4133	14	novei	novei	JJ
cord-015021-pol2qm74	4133	15	clinical	clinical	JJ
cord-015021-pol2qm74	4133	16	interventions	intervention	NNS
cord-015021-pol2qm74	4133	17	to	to	TO
cord-015021-pol2qm74	4133	18	improve	improve	VB
cord-015021-pol2qm74	4133	19	immune	immune	JJ
cord-015021-pol2qm74	4133	20	response	response	NN
cord-015021-pol2qm74	4133	21	and	and	CC
cord-015021-pol2qm74	4133	22	decrease	decrease	VB
cord-015021-pol2qm74	4133	23	the	the	DT
cord-015021-pol2qm74	4133	24	risk	risk	NN
cord-015021-pol2qm74	4133	25	for	for	IN
cord-015021-pol2qm74	4133	26	infection	infection	NN
cord-015021-pol2qm74	4133	27	in	in	IN
cord-015021-pol2qm74	4133	28	trauma	trauma	NN
cord-015021-pol2qm74	4133	29	and	and	CC
cord-015021-pol2qm74	4133	30	surgical	surgical	JJ
cord-015021-pol2qm74	4133	31	patients	patient	NNS
cord-015021-pol2qm74	4133	32	.	.	.
cord-015021-pol2qm74	4134	1	.	.	.
cord-015021-pol2qm74	4135	1	Animals	animal	NNS
cord-015021-pol2qm74	4135	2	receiving	receive	VBG
cord-015021-pol2qm74	4135	3	E	E	NNS
cord-015021-pol2qm74	4135	4	were	be	VBD
cord-015021-pol2qm74	4135	5	given	give	VBN
cord-015021-pol2qm74	4135	6	a	a	DT
cord-015021-pol2qm74	4135	7	single	single	JJ
cord-015021-pol2qm74	4135	8	dose	dose	NN
cord-015021-pol2qm74	4135	9	daily	daily	RB
cord-015021-pol2qm74	4135	10	of	of	IN
cord-015021-pol2qm74	4135	11	either	either	DT
cord-015021-pol2qm74	4135	12	2.4	2.4	CD
cord-015021-pol2qm74	4135	13	g	g	NN
cord-015021-pol2qm74	4135	14	/	/	SYM
cord-015021-pol2qm74	4135	15	kg	kg	NN
cord-015021-pol2qm74	4135	16	of	of	IN
cord-015021-pol2qm74	4135	17	E	e	NN
cord-015021-pol2qm74	4135	18	in	in	IN
cord-015021-pol2qm74	4135	19	a	a	DT
cord-015021-pol2qm74	4135	20	20	20	CD
cord-015021-pol2qm74	4135	21	%	%	NN
cord-015021-pol2qm74	4135	22	solution	solution	NN
cord-015021-pol2qm74	4135	23	by	by	IN
cord-015021-pol2qm74	4135	24	garage	garage	NN
cord-015021-pol2qm74	4135	25	(	(	-LRB-
cord-015021-pol2qm74	4135	26	GE	GE	NNP
cord-015021-pol2qm74	4135	27	)	)	-RRB-
cord-015021-pol2qm74	4135	28	,	,	,
cord-015021-pol2qm74	4135	29	or	or	CC
cord-015021-pol2qm74	4135	30	1.25	1.25	CD
cord-015021-pol2qm74	4135	31	g	g	NN
cord-015021-pol2qm74	4135	32	/	/	SYM
cord-015021-pol2qm74	4135	33	kg	kg	NNS
cord-015021-pol2qm74	4135	34	of	of	IN
cord-015021-pol2qm74	4135	35	sterile	sterile	JJ
cord-015021-pol2qm74	4135	36	IVE	IVE	NNP
cord-015021-pol2qm74	4135	37	in	in	IN
cord-015021-pol2qm74	4135	38	saline	saline	NN
cord-015021-pol2qm74	4135	39	.	.	.
cord-015021-pol2qm74	4136	1	Four	four	CD
cord-015021-pol2qm74	4136	2	hours	hour	NNS
cord-015021-pol2qm74	4136	3	following	follow	VBG
cord-015021-pol2qm74	4136	4	the	the	DT
cord-015021-pol2qm74	4136	5	last	last	JJ
cord-015021-pol2qm74	4136	6	dose	dose	NN
cord-015021-pol2qm74	4136	7	,	,	,
cord-015021-pol2qm74	4136	8	bum	bum	JJ
cord-015021-pol2qm74	4136	9	animals	animal	NNS
cord-015021-pol2qm74	4136	10	were	be	VBD
cord-015021-pol2qm74	4136	11	subjected	subject	VBN
cord-015021-pol2qm74	4136	12	to	to	IN
cord-015021-pol2qm74	4136	13	a	a	DT
cord-015021-pol2qm74	4136	14	30	30	CD
cord-015021-pol2qm74	4136	15	%	%	NN
cord-015021-pol2qm74	4136	16	body	body	NN
cord-015021-pol2qm74	4136	17	surface	surface	NN
cord-015021-pol2qm74	4136	18	area	area	NN
cord-015021-pol2qm74	4136	19	bum	bum	JJ
cord-015021-pol2qm74	4136	20	injury	injury	NN
cord-015021-pol2qm74	4136	21	to	to	IN
cord-015021-pol2qm74	4136	22	their	-PRON-	PRP$
cord-015021-pol2qm74	4136	23	dorsum	dorsum	NN
cord-015021-pol2qm74	4136	24	.	.	.
cord-015021-pol2qm74	4137	1	Twentyfour	twentyfour	NN
cord-015021-pol2qm74	4137	2	hours	hour	NNS
cord-015021-pol2qm74	4137	3	following	follow	VBG
cord-015021-pol2qm74	4137	4	injury	injury	NN
cord-015021-pol2qm74	4137	5	,	,	,
cord-015021-pol2qm74	4137	6	the	the	DT
cord-015021-pol2qm74	4137	7	animals	animal	NNS
cord-015021-pol2qm74	4137	8	were	be	VBD
cord-015021-pol2qm74	4137	9	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	4137	10	and	and	CC
cord-015021-pol2qm74	4137	11	spleen	spleen	NN
cord-015021-pol2qm74	4137	12	cells	cell	NNS
cord-015021-pol2qm74	4137	13	were	be	VBD
cord-015021-pol2qm74	4137	14	harvested	harvest	VBN
cord-015021-pol2qm74	4137	15	for	for	IN
cord-015021-pol2qm74	4137	16	assessment	assessment	NN
cord-015021-pol2qm74	4137	17	of	of	IN
cord-015021-pol2qm74	4137	18	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4137	19	function	function	NN
cord-015021-pol2qm74	4137	20	.	.	.
cord-015021-pol2qm74	4138	1	Splenocytes	Splenocytes	NNP
cord-015021-pol2qm74	4138	2	were	be	VBD
cord-015021-pol2qm74	4138	3	prepared	prepare	VBN
cord-015021-pol2qm74	4138	4	by	by	IN
cord-015021-pol2qm74	4138	5	mincing	mince	VBG
cord-015021-pol2qm74	4138	6	the	the	DT
cord-015021-pol2qm74	4138	7	spleen	spleen	NNS
cord-015021-pol2qm74	4138	8	,	,	,
cord-015021-pol2qm74	4138	9	followed	follow	VBN
cord-015021-pol2qm74	4138	10	by	by	IN
cord-015021-pol2qm74	4138	11	incubation	incubation	NN
cord-015021-pol2qm74	4138	12	on	on	IN
cord-015021-pol2qm74	4138	13	glass	glass	NN
cord-015021-pol2qm74	4138	14	petri	petri	JJ
cord-015021-pol2qm74	4138	15	dishes	dish	NNS
cord-015021-pol2qm74	4138	16	to	to	TO
cord-015021-pol2qm74	4138	17	remove	remove	VB
cord-015021-pol2qm74	4138	18	adherent	adherent	JJ
cord-015021-pol2qm74	4138	19	macrophages	macrophage	NNS
cord-015021-pol2qm74	4138	20	.	.	.
cord-015021-pol2qm74	4139	1	Non	non	JJ
cord-015021-pol2qm74	4139	2	-	-	JJ
cord-015021-pol2qm74	4139	3	adherent	adherent	JJ
cord-015021-pol2qm74	4139	4	cells	cell	NNS
cord-015021-pol2qm74	4139	5	were	be	VBD
cord-015021-pol2qm74	4139	6	then	then	RB
cord-015021-pol2qm74	4139	7	tested	test	VBN
cord-015021-pol2qm74	4139	8	for	for	IN
cord-015021-pol2qm74	4139	9	proliferative	proliferative	JJ
cord-015021-pol2qm74	4139	10	response	response	NN
cord-015021-pol2qm74	4139	11	to	to	IN
cord-015021-pol2qm74	4139	12	T	t	NN
cord-015021-pol2qm74	4139	13	-	-	HYPH
cord-015021-pol2qm74	4139	14	cell	cell	NN
cord-015021-pol2qm74	4139	15	mitogen	mitogen	NN
cord-015021-pol2qm74	4139	16	Concanavalin	Concanavalin	NNP
cord-015021-pol2qm74	4139	17	A	A	NNP
cord-015021-pol2qm74	4139	18	(	(	-LRB-
cord-015021-pol2qm74	4139	19	Con	Con	NNP
cord-015021-pol2qm74	4139	20	A	A	NNP
cord-015021-pol2qm74	4139	21	)	)	-RRB-
cord-015021-pol2qm74	4139	22	and	and	CC
cord-015021-pol2qm74	4139	23	B	b	NN
cord-015021-pol2qm74	4139	24	-	-	HYPH
cord-015021-pol2qm74	4139	25	cell	cell	NN
cord-015021-pol2qm74	4139	26	mitogen	mitogen	NN
cord-015021-pol2qm74	4139	27	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	4139	28	(	(	-LRB-
cord-015021-pol2qm74	4139	29	LPS	LPS	NNP
cord-015021-pol2qm74	4139	30	)	)	-RRB-
cord-015021-pol2qm74	4139	31	.	.	.
cord-015021-pol2qm74	4140	1	Data	datum	NNS
cord-015021-pol2qm74	4140	2	were	be	VBD
cord-015021-pol2qm74	4140	3	analyzed	analyze	VBN
cord-015021-pol2qm74	4140	4	by	by	IN
cord-015021-pol2qm74	4140	5	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	4140	6	.	.	.
cord-015021-pol2qm74	4141	1	RESULTS	result	NNS
cord-015021-pol2qm74	4141	2	:	:	:
cord-015021-pol2qm74	4142	1	Chronic	chronic	JJ
cord-015021-pol2qm74	4142	2	alcohol	alcohol	NN
cord-015021-pol2qm74	4142	3	exposure	exposure	NN
cord-015021-pol2qm74	4142	4	and	and	CC
cord-015021-pol2qm74	4142	5	burn	burn	VB
cord-015021-pol2qm74	4142	6	injury	injury	NN
cord-015021-pol2qm74	4142	7	independently	independently	RB
cord-015021-pol2qm74	4142	8	inhibit	inhibit	VBP
cord-015021-pol2qm74	4142	9	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4142	10	response	response	NN
cord-015021-pol2qm74	4142	11	to	to	IN
cord-015021-pol2qm74	4142	12	Con	Con	NNP
cord-015021-pol2qm74	4142	13	A	A	NNP
cord-015021-pol2qm74	4142	14	but	but	CC
cord-015021-pol2qm74	4142	15	not	not	RB
cord-015021-pol2qm74	4142	16	to	to	IN
cord-015021-pol2qm74	4142	17	LPS	LPS	NNP
cord-015021-pol2qm74	4142	18	.	.	.
cord-015021-pol2qm74	4143	1	The	the	DT
cord-015021-pol2qm74	4143	2	combination	combination	NN
cord-015021-pol2qm74	4143	3	of	of	IN
cord-015021-pol2qm74	4143	4	E	E	NNP
cord-015021-pol2qm74	4143	5	plus	plus	CC
cord-015021-pol2qm74	4143	6	bum	bum	JJ
cord-015021-pol2qm74	4143	7	injury	injury	NN
cord-015021-pol2qm74	4143	8	,	,	,
cord-015021-pol2qm74	4143	9	however	however	RB
cord-015021-pol2qm74	4143	10	,	,	,
cord-015021-pol2qm74	4143	11	pmfouedly	pmfouedly	RB
cord-015021-pol2qm74	4143	12	decreases	decrease	VBZ
cord-015021-pol2qm74	4143	13	this	this	DT
cord-015021-pol2qm74	4143	14	response	response	NN
cord-015021-pol2qm74	4143	15	to	to	IN
cord-015021-pol2qm74	4143	16	both	both	DT
cord-015021-pol2qm74	4143	17	Con	Con	NNP
cord-015021-pol2qm74	4143	18	A	A	NNP
cord-015021-pol2qm74	4143	19	and	and	CC
cord-015021-pol2qm74	4143	20	LPS	LPS	NNP
cord-015021-pol2qm74	4143	21	as	as	IN
cord-015021-pol2qm74	4143	22	outlined	outline	VBN
cord-015021-pol2qm74	4143	23	in	in	IN
cord-015021-pol2qm74	4143	24	the	the	DT
cord-015021-pol2qm74	4143	25	This	this	DT
cord-015021-pol2qm74	4143	26	data	data	NN
cord-015021-pol2qm74	4143	27	clearly	clearly	RB
cord-015021-pol2qm74	4143	28	identifies	identify	VBZ
cord-015021-pol2qm74	4143	29	the	the	DT
cord-015021-pol2qm74	4143	30	synergistic	synergistic	JJ
cord-015021-pol2qm74	4143	31	impairment	impairment	NN
cord-015021-pol2qm74	4143	32	of	of	IN
cord-015021-pol2qm74	4143	33	immune	immune	JJ
cord-015021-pol2qm74	4143	34	function	function	NN
cord-015021-pol2qm74	4143	35	produced	produce	VBN
cord-015021-pol2qm74	4143	36	by	by	IN
cord-015021-pol2qm74	4143	37	ethanol	ethanol	NN
cord-015021-pol2qm74	4143	38	and	and	CC
cord-015021-pol2qm74	4143	39	bum	bum	NN
cord-015021-pol2qm74	4143	40	injury	injury	NN
cord-015021-pol2qm74	4143	41	.	.	.
cord-015021-pol2qm74	4144	1	It	-PRON-	PRP
cord-015021-pol2qm74	4144	2	is	be	VBZ
cord-015021-pol2qm74	4144	3	furthermore	furthermore	RB
cord-015021-pol2qm74	4144	4	apparent	apparent	JJ
cord-015021-pol2qm74	4144	5	that	that	IN
cord-015021-pol2qm74	4144	6	Ibis	Ibis	NNP
cord-015021-pol2qm74	4144	7	effect	effect	NN
cord-015021-pol2qm74	4144	8	is	be	VBZ
cord-015021-pol2qm74	4144	9	gut	gut	NN
cord-015021-pol2qm74	4144	10	mediated	mediate	VBN
cord-015021-pol2qm74	4144	11	and	and	CC
cord-015021-pol2qm74	4144	12	that	that	IN
cord-015021-pol2qm74	4144	13	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	4144	14	exposure	exposure	NN
cord-015021-pol2qm74	4144	15	to	to	IN
cord-015021-pol2qm74	4144	16	alcohol	alcohol	NN
cord-015021-pol2qm74	4144	17	is	be	VBZ
cord-015021-pol2qm74	4144	18	necessary	necessary	JJ
cord-015021-pol2qm74	4144	19	to	to	TO
cord-015021-pol2qm74	4144	20	produce	produce	VB
cord-015021-pol2qm74	4144	21	this	this	DT
cord-015021-pol2qm74	4144	22	effect	effect	NN
cord-015021-pol2qm74	4144	23	.	.	.
cord-015021-pol2qm74	4145	1	Further	further	JJ
cord-015021-pol2qm74	4145	2	studies	study	NNS
cord-015021-pol2qm74	4145	3	will	will	MD
cord-015021-pol2qm74	4145	4	work	work	VB
cord-015021-pol2qm74	4145	5	to	to	TO
cord-015021-pol2qm74	4145	6	identify	identify	VB
cord-015021-pol2qm74	4145	7	cellular	cellular	JJ
cord-015021-pol2qm74	4145	8	and	and	CC
cord-015021-pol2qm74	4145	9	subcellular	subcellular	JJ
cord-015021-pol2qm74	4145	10	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4145	11	to	to	TO
cord-015021-pol2qm74	4145	12	explain	explain	VB
cord-015021-pol2qm74	4145	13	this	this	DT
cord-015021-pol2qm74	4145	14	effect	effect	NN
cord-015021-pol2qm74	4145	15	.	.	.
cord-015021-pol2qm74	4146	1	In	in	IN
cord-015021-pol2qm74	4146	2	experimental	experimental	JJ
cord-015021-pol2qm74	4146	3	animal	animal	NN
cord-015021-pol2qm74	4146	4	studies	study	NNS
cord-015021-pol2qm74	4146	5	and	and	CC
cord-015021-pol2qm74	4146	6	investigations	investigation	NNS
cord-015021-pol2qm74	4146	7	on	on	IN
cord-015021-pol2qm74	4146	8	human	human	JJ
cord-015021-pol2qm74	4146	9	volunteers	volunteer	NNS
cord-015021-pol2qm74	4146	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4146	11	infusion	infusion	NN
cord-015021-pol2qm74	4146	12	is	be	VBZ
cord-015021-pol2qm74	4146	13	mgulary	mgulary	NN
cord-015021-pol2qm74	4146	14	accompanied	accompany	VBN
cord-015021-pol2qm74	4146	15	by	by	IN
cord-015021-pol2qm74	4146	16	the	the	DT
cord-015021-pol2qm74	4146	17	release	release	NN
cord-015021-pol2qm74	4146	18	of	of	IN
cord-015021-pol2qm74	4146	19	the	the	DT
cord-015021-pol2qm74	4146	20	cytokine	cytokine	NN
cord-015021-pol2qm74	4146	21	tumor	tumor	NN
cord-015021-pol2qm74	4146	22	necrosis	necrosis	NN
cord-015021-pol2qm74	4146	23	factor	factor	NN
cord-015021-pol2qm74	4146	24	a	a	NN
cord-015021-pol2qm74	4146	25	(	(	-LRB-
cord-015021-pol2qm74	4146	26	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	4146	27	)	)	-RRB-
cord-015021-pol2qm74	4146	28	determined	determine	VBN
cord-015021-pol2qm74	4146	29	by	by	IN
cord-015021-pol2qm74	4146	30	ELISA	ELISA	NNP
cord-015021-pol2qm74	4146	31	technique	technique	NN
cord-015021-pol2qm74	4146	32	.	.	.
cord-015021-pol2qm74	4147	1	In	in	IN
cord-015021-pol2qm74	4147	2	patients	patient	NNS
cord-015021-pol2qm74	4147	3	with	with	IN
cord-015021-pol2qm74	4147	4	menigococcal	menigococcal	JJ
cord-015021-pol2qm74	4147	5	sepsis	sepsis	NN
cord-015021-pol2qm74	4147	6	also	also	RB
cord-015021-pol2qm74	4147	7	elevated	elevate	VBD
cord-015021-pol2qm74	4147	8	TNF	TNF	NNP
cord-015021-pol2qm74	4147	9	-	-	:
cord-015021-pol2qm74	4147	10	a	a	DT
cord-015021-pol2qm74	4147	11	values	value	NNS
cord-015021-pol2qm74	4147	12	have	have	VBP
cord-015021-pol2qm74	4147	13	been	be	VBN
cord-015021-pol2qm74	4147	14	found	find	VBN
cord-015021-pol2qm74	4147	15	using	use	VBG
cord-015021-pol2qm74	4147	16	a	a	DT
cord-015021-pol2qm74	4147	17	functional	functional	JJ
cord-015021-pol2qm74	4147	18	assay	assay	NN
cord-015021-pol2qm74	4147	19	.	.	.
cord-015021-pol2qm74	4148	1	We	-PRON-	PRP
cord-015021-pol2qm74	4148	2	have	have	VBP
cord-015021-pol2qm74	4148	3	studied	study	VBN
cord-015021-pol2qm74	4148	4	the	the	DT
cord-015021-pol2qm74	4148	5	role	role	NN
cord-015021-pol2qm74	4148	6	of	of	IN
cord-015021-pol2qm74	4148	7	TNF	TNF	NNP
cord-015021-pol2qm74	4148	8	-	-	HYPH
cord-015021-pol2qm74	4148	9	et	et	NNP
cord-015021-pol2qm74	4148	10	in	in	IN
cord-015021-pol2qm74	4148	11	surgical	surgical	JJ
cord-015021-pol2qm74	4148	12	ICU	ICU	NNP
cord-015021-pol2qm74	4148	13	patients	patient	NNS
cord-015021-pol2qm74	4148	14	with	with	IN
cord-015021-pol2qm74	4148	15	sepsis	sepsis	NN
cord-015021-pol2qm74	4148	16	.	.	.
cord-015021-pol2qm74	4149	1	Using	use	VBG
cord-015021-pol2qm74	4149	2	functional	functional	JJ
cord-015021-pol2qm74	4149	3	technique	technique	NN
cord-015021-pol2qm74	4149	4	,	,	,
cord-015021-pol2qm74	4149	5	we	-PRON-	PRP
cord-015021-pol2qm74	4149	6	were	be	VBD
cord-015021-pol2qm74	4149	7	not	not	RB
cord-015021-pol2qm74	4149	8	able	able	JJ
cord-015021-pol2qm74	4149	9	to	to	TO
cord-015021-pol2qm74	4149	10	detect	detect	VB
cord-015021-pol2qm74	4149	11	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	4149	12	activities	activity	NNS
cord-015021-pol2qm74	4149	13	in	in	IN
cord-015021-pol2qm74	4149	14	the	the	DT
cord-015021-pol2qm74	4149	15	patient	patient	NN
cord-015021-pol2qm74	4149	16	plasmas	plasma	NNS
cord-015021-pol2qm74	4149	17	.	.	.
cord-015021-pol2qm74	4150	1	When	when	WRB
cord-015021-pol2qm74	4150	2	this	this	DT
cord-015021-pol2qm74	4150	3	cytokine	cytokine	NN
cord-015021-pol2qm74	4150	4	,	,	,
cord-015021-pol2qm74	4150	5	however	however	RB
cord-015021-pol2qm74	4150	6	,	,	,
cord-015021-pol2qm74	4150	7	was	be	VBD
cord-015021-pol2qm74	4150	8	determined	determine	VBN
cord-015021-pol2qm74	4150	9	by	by	IN
cord-015021-pol2qm74	4150	10	immunochemicaI	immunochemicaI	NNP
cord-015021-pol2qm74	4150	11	technique	technique	NN
cord-015021-pol2qm74	4150	12	(	(	-LRB-
cord-015021-pol2qm74	4150	13	EL1SA	EL1SA	NNP
cord-015021-pol2qm74	4150	14	)	)	-RRB-
cord-015021-pol2qm74	4150	15	elevated	elevate	VBD
cord-015021-pol2qm74	4150	16	TNF	TNF	NNP
cord-015021-pol2qm74	4150	17	-	-	HYPH
cord-015021-pol2qm74	4150	18	e~	e~	JJ
cord-015021-pol2qm74	4150	19	values	value	NNS
cord-015021-pol2qm74	4150	20	where	where	WRB
cord-015021-pol2qm74	4150	21	frequently	frequently	RB
cord-015021-pol2qm74	4150	22	oberserved	oberserve	VBN
cord-015021-pol2qm74	4150	23	.	.	.
cord-015021-pol2qm74	4151	1	In	in	IN
cord-015021-pol2qm74	4151	2	order	order	NN
cord-015021-pol2qm74	4151	3	to	to	TO
cord-015021-pol2qm74	4151	4	further	further	RB
cord-015021-pol2qm74	4151	5	elucidate	elucidate	VB
cord-015021-pol2qm74	4151	6	these	these	DT
cord-015021-pol2qm74	4151	7	observations	observation	NNS
cord-015021-pol2qm74	4151	8	,	,	,
cord-015021-pol2qm74	4151	9	we	-PRON-	PRP
cord-015021-pol2qm74	4151	10	studied	study	VBD
cord-015021-pol2qm74	4151	11	shedding	shed	VBG
cord-015021-pol2qm74	4151	12	of	of	IN
cord-015021-pol2qm74	4151	13	TNF	TNF	NNP
cord-015021-pol2qm74	4151	14	receptors	receptor	NNS
cord-015021-pol2qm74	4151	15	in	in	IN
cord-015021-pol2qm74	4151	16	the	the	DT
cord-015021-pol2qm74	4151	17	patients	patient	NNS
cord-015021-pol2qm74	4151	18	.	.	.
cord-015021-pol2qm74	4152	1	In	in	IN
cord-015021-pol2qm74	4152	2	these	these	DT
cord-015021-pol2qm74	4152	3	studies	study	NNS
cord-015021-pol2qm74	4152	4	,	,	,
cord-015021-pol2qm74	4152	5	we	-PRON-	PRP
cord-015021-pol2qm74	4152	6	noticed	notice	VBD
cord-015021-pol2qm74	4152	7	that	that	IN
cord-015021-pol2qm74	4152	8	shedding	shedding	NN
cord-015021-pol2qm74	4152	9	of	of	IN
cord-015021-pol2qm74	4152	10	TNF	TNF	NNP
cord-015021-pol2qm74	4152	11	receptors	receptor	NNS
cord-015021-pol2qm74	4152	12	oecured	oecure	VBN
cord-015021-pol2qm74	4152	13	regulary	regulary	RB
cord-015021-pol2qm74	4152	14	in	in	IN
cord-015021-pol2qm74	4152	15	the	the	DT
cord-015021-pol2qm74	4152	16	patients	patient	NNS
cord-015021-pol2qm74	4152	17	.	.	.
cord-015021-pol2qm74	4153	1	At	at	IN
cord-015021-pol2qm74	4153	2	the	the	DT
cord-015021-pol2qm74	4153	3	time	time	NN
cord-015021-pol2qm74	4153	4	of	of	IN
cord-015021-pol2qm74	4153	5	diagnosis	diagnosis	NN
cord-015021-pol2qm74	4153	6	,	,	,
cord-015021-pol2qm74	4153	7	soluble	soluble	JJ
cord-015021-pol2qm74	4153	8	TNF	TNF	NNP
cord-015021-pol2qm74	4153	9	receptor	receptor	NN
cord-015021-pol2qm74	4153	10	p55	p55	NN
cord-015021-pol2qm74	4153	11	and	and	CC
cord-015021-pol2qm74	4153	12	p75	p75	NNP
cord-015021-pol2qm74	4153	13	were	be	VBD
cord-015021-pol2qm74	4153	14	both	both	DT
cord-015021-pol2qm74	4153	15	2	2	CD
cord-015021-pol2qm74	4153	16	-	-	SYM
cord-015021-pol2qm74	4153	17	3	3	CD
cord-015021-pol2qm74	4153	18	fold	fold	VBP
cord-015021-pol2qm74	4153	19	higher	higher	RBR
cord-015021-pol2qm74	4153	20	than	than	IN
cord-015021-pol2qm74	4153	21	values	value	NNS
cord-015021-pol2qm74	4153	22	found	find	VBN
cord-015021-pol2qm74	4153	23	in	in	IN
cord-015021-pol2qm74	4153	24	plasma	plasma	NN
cord-015021-pol2qm74	4153	25	samples	sample	NNS
cord-015021-pol2qm74	4153	26	obtained	obtain	VBN
cord-015021-pol2qm74	4153	27	prior	prior	RB
cord-015021-pol2qm74	4153	28	to	to	TO
cord-015021-pol2qm74	4153	29	die	die	VB
cord-015021-pol2qm74	4153	30	diagnosis	diagnosis	NN
cord-015021-pol2qm74	4153	31	of	of	IN
cord-015021-pol2qm74	4153	32	sepsis	sepsis	NN
cord-015021-pol2qm74	4153	33	.	.	.
cord-015021-pol2qm74	4154	1	We	-PRON-	PRP
cord-015021-pol2qm74	4154	2	also	also	RB
cord-015021-pol2qm74	4154	3	observed	observe	VBD
cord-015021-pol2qm74	4154	4	that	that	IN
cord-015021-pol2qm74	4154	5	the	the	DT
cord-015021-pol2qm74	4154	6	sepsis	sepsis	NN
cord-015021-pol2qm74	4154	7	patients	patient	NNS
cord-015021-pol2qm74	4154	8	revealed	reveal	VBD
cord-015021-pol2qm74	4154	9	higher	high	JJR
cord-015021-pol2qm74	4154	10	maximum	maximum	JJ
cord-015021-pol2qm74	4154	11	values	value	NNS
cord-015021-pol2qm74	4154	12	of	of	IN
cord-015021-pol2qm74	4154	13	p55	p55	NN
cord-015021-pol2qm74	4154	14	and	and	CC
cord-015021-pol2qm74	4154	15	p75	p75	NN
cord-015021-pol2qm74	4154	16	during	during	IN
cord-015021-pol2qm74	4154	17	the	the	DT
cord-015021-pol2qm74	4154	18	ICU	ICU	NNP
cord-015021-pol2qm74	4154	19	stay	stay	NN
cord-015021-pol2qm74	4154	20	compared	compare	VBN
cord-015021-pol2qm74	4154	21	to	to	IN
cord-015021-pol2qm74	4154	22	values	value	NNS
cord-015021-pol2qm74	4154	23	found	find	VBN
cord-015021-pol2qm74	4154	24	in	in	IN
cord-015021-pol2qm74	4154	25	surgical	surgical	JJ
cord-015021-pol2qm74	4154	26	ICU	ICU	NNP
cord-015021-pol2qm74	4154	27	patients	patient	NNS
cord-015021-pol2qm74	4154	28	without	without	IN
cord-015021-pol2qm74	4154	29	sepsis	sepsis	NN
cord-015021-pol2qm74	4154	30	.	.	.
cord-015021-pol2qm74	4155	1	These	these	DT
cord-015021-pol2qm74	4155	2	observations	observation	NNS
cord-015021-pol2qm74	4155	3	indicate	indicate	VBP
cord-015021-pol2qm74	4155	4	that	that	IN
cord-015021-pol2qm74	4155	5	soluble	soluble	JJ
cord-015021-pol2qm74	4155	6	TNF	TNF	NNP
cord-015021-pol2qm74	4155	7	receptors	receptor	NNS
cord-015021-pol2qm74	4155	8	are	be	VBP
cord-015021-pol2qm74	4155	9	available	available	JJ
cord-015021-pol2qm74	4155	10	in	in	IN
cord-015021-pol2qm74	4155	11	sufficient	sufficient	JJ
cord-015021-pol2qm74	4155	12	amounts	amount	NNS
cord-015021-pol2qm74	4155	13	to	to	TO
cord-015021-pol2qm74	4155	14	bind	bind	VB
cord-015021-pol2qm74	4155	15	TNF	TNF	NNP
cord-015021-pol2qm74	4155	16	-	-	HYPH
cord-015021-pol2qm74	4155	17	ot	ot	NNP
cord-015021-pol2qm74	4155	18	which	which	WDT
cord-015021-pol2qm74	4155	19	is	be	VBZ
cord-015021-pol2qm74	4155	20	released	release	VBN
cord-015021-pol2qm74	4155	21	in	in	IN
cord-015021-pol2qm74	4155	22	surgical	surgical	JJ
cord-015021-pol2qm74	4155	23	patients	patient	NNS
cord-015021-pol2qm74	4155	24	developing	develop	VBG
cord-015021-pol2qm74	4155	25	sepsis	sepsis	NN
cord-015021-pol2qm74	4155	26	.	.	.
cord-015021-pol2qm74	4156	1	This	this	DT
cord-015021-pol2qm74	4156	2	mechanism	mechanism	NN
cord-015021-pol2qm74	4156	3	may	may	MD
cord-015021-pol2qm74	4156	4	explain	explain	VB
cord-015021-pol2qm74	4156	5	why	why	WRB
cord-015021-pol2qm74	4156	6	functional	functional	JJ
cord-015021-pol2qm74	4156	7	TNF	TNF	NNP
cord-015021-pol2qm74	4156	8	-	-	HYPH
cord-015021-pol2qm74	4156	9	c~	c~	NNP
cord-015021-pol2qm74	4156	10	was	be	VBD
cord-015021-pol2qm74	4156	11	not	not	RB
cord-015021-pol2qm74	4156	12	detected	detect	VBN
cord-015021-pol2qm74	4156	13	in	in	IN
cord-015021-pol2qm74	4156	14	the	the	DT
cord-015021-pol2qm74	4156	15	patients	patient	NNS
cord-015021-pol2qm74	4156	16	.	.	.
cord-015021-pol2qm74	4157	1	Institute	Institute	NNP
cord-015021-pol2qm74	4157	2	for	for	IN
cord-015021-pol2qm74	4157	3	Surgical	Surgical	NNP
cord-015021-pol2qm74	4157	4	Research	Research	NNP
cord-015021-pol2qm74	4157	5	,	,	,
cord-015021-pol2qm74	4157	6	Rikshospitalet	Rikshospitalet	NNP
cord-015021-pol2qm74	4157	7	,	,	,
cord-015021-pol2qm74	4157	8	The	the	DT
cord-015021-pol2qm74	4157	9	National	National	NNP
cord-015021-pol2qm74	4157	10	Hospital	Hospital	NNP
cord-015021-pol2qm74	4157	11	,	,	,
cord-015021-pol2qm74	4157	12	University	University	NNP
cord-015021-pol2qm74	4157	13	of	of	IN
cord-015021-pol2qm74	4157	14	Oslo	Oslo	NNP
cord-015021-pol2qm74	4157	15	,	,	,
cord-015021-pol2qm74	4157	16	0027	0027	CD
cord-015021-pol2qm74	4157	17	Oslo	Oslo	NNP
cord-015021-pol2qm74	4157	18	,	,	,
cord-015021-pol2qm74	4157	19	Norway	Norway	NNP
cord-015021-pol2qm74	4157	20	.	.	.
cord-015021-pol2qm74	4158	1	Decker	Decker	NNP
cord-015021-pol2qm74	4158	2	,	,	,
cord-015021-pol2qm74	4158	3	D.	D.	NNP
cord-015021-pol2qm74	4158	4	,	,	,
cord-015021-pol2qm74	4158	5	Sch6ndorf	Sch6ndorf	NNP
cord-015021-pol2qm74	4158	6	,	,	,
cord-015021-pol2qm74	4158	7	M.	M.	NNP
cord-015021-pol2qm74	4158	8	,	,	,
cord-015021-pol2qm74	4158	9	Bidlingrnaier	Bidlingrnaier	NNP
cord-015021-pol2qm74	4158	10	,	,	,
cord-015021-pol2qm74	4158	11	F.	F.	NNP
cord-015021-pol2qm74	4158	12	,	,	,
cord-015021-pol2qm74	4158	13	Hirner	Hirner	NNP
cord-015021-pol2qm74	4158	14	,	,	,
cord-015021-pol2qm74	4158	15	A.	A.	NNP
cord-015021-pol2qm74	4158	16	,	,	,
cord-015021-pol2qm74	4158	17	yon	yon	NNP
cord-015021-pol2qm74	4158	18	Rfcker	Rfcker	NNP
cord-015021-pol2qm74	4158	19	,	,	,
cord-015021-pol2qm74	4158	20	A.	a.	NN
cord-015021-pol2qm74	4159	1	The	the	DT
cord-015021-pol2qm74	4159	2	advantage	advantage	NN
cord-015021-pol2qm74	4159	3	oflaparoscopic	oflaparoscopic	JJ
cord-015021-pol2qm74	4159	4	cholecystectomy	cholecystectomy	NN
cord-015021-pol2qm74	4159	5	over	over	IN
cord-015021-pol2qm74	4159	6	conventional	conventional	JJ
cord-015021-pol2qm74	4159	7	open	open	JJ
cord-015021-pol2qm74	4159	8	surgical	surgical	JJ
cord-015021-pol2qm74	4159	9	approaches	approach	NNS
cord-015021-pol2qm74	4159	10	in	in	IN
cord-015021-pol2qm74	4159	11	the	the	DT
cord-015021-pol2qm74	4159	12	treatment	treatment	NN
cord-015021-pol2qm74	4159	13	of	of	IN
cord-015021-pol2qm74	4159	14	symptomatic	symptomatic	JJ
cord-015021-pol2qm74	4159	15	cholelithiasis	cholelithiasis	NN
cord-015021-pol2qm74	4159	16	has	have	VBZ
cord-015021-pol2qm74	4159	17	been	be	VBN
cord-015021-pol2qm74	4159	18	shown	show	VBN
cord-015021-pol2qm74	4159	19	convincingly	convincingly	RB
cord-015021-pol2qm74	4159	20	by	by	IN
cord-015021-pol2qm74	4159	21	clinical	clinical	JJ
cord-015021-pol2qm74	4159	22	studies	study	NNS
cord-015021-pol2qm74	4159	23	.	.	.
cord-015021-pol2qm74	4160	1	In	in	IN
cord-015021-pol2qm74	4160	2	order	order	NN
cord-015021-pol2qm74	4160	3	to	to	TO
cord-015021-pol2qm74	4160	4	facilitate	facilitate	VB
cord-015021-pol2qm74	4160	5	comparisons	comparison	NNS
cord-015021-pol2qm74	4160	6	of	of	IN
cord-015021-pol2qm74	4160	7	different	different	JJ
cord-015021-pol2qm74	4160	8	surgical	surgical	JJ
cord-015021-pol2qm74	4160	9	approaches	approach	NNS
cord-015021-pol2qm74	4160	10	,	,	,
cord-015021-pol2qm74	4160	11	we	-PRON-	PRP
cord-015021-pol2qm74	4160	12	evaluated	evaluate	VBD
cord-015021-pol2qm74	4160	13	the	the	DT
cord-015021-pol2qm74	4160	14	cell	cell	NN
cord-015021-pol2qm74	4160	15	biological	biological	JJ
cord-015021-pol2qm74	4160	16	characteristics	characteristic	NNS
cord-015021-pol2qm74	4160	17	of	of	IN
cord-015021-pol2qm74	4160	18	tissue	tissue	NN
cord-015021-pol2qm74	4160	19	trauma	trauma	NN
cord-015021-pol2qm74	4160	20	by	by	IN
cord-015021-pol2qm74	4160	21	measuring	measure	VBG
cord-015021-pol2qm74	4160	22	changes	change	NNS
cord-015021-pol2qm74	4160	23	in	in	IN
cord-015021-pol2qm74	4160	24	various	various	JJ
cord-015021-pol2qm74	4160	25	cell	cell	NN
cord-015021-pol2qm74	4160	26	surface	surface	NN
cord-015021-pol2qm74	4160	27	markers	marker	NNS
cord-015021-pol2qm74	4160	28	on	on	IN
cord-015021-pol2qm74	4160	29	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	4160	30	and	and	CC
cord-015021-pol2qm74	4160	31	eytokines	eytokine	NNS
cord-015021-pol2qm74	4160	32	in	in	IN
cord-015021-pol2qm74	4160	33	plasma	plasma	NN
cord-015021-pol2qm74	4160	34	as	as	IN
cord-015021-pol2qm74	4160	35	a	a	DT
cord-015021-pol2qm74	4160	36	possible	possible	JJ
cord-015021-pol2qm74	4160	37	means	mean	VBZ
cord-015021-pol2qm74	4160	38	to	to	TO
cord-015021-pol2qm74	4160	39	assess	assess	VB
cord-015021-pol2qm74	4160	40	tissue	tissue	NN
cord-015021-pol2qm74	4160	41	trauma	trauma	NN
cord-015021-pol2qm74	4160	42	in	in	IN
cord-015021-pol2qm74	4160	43	choleeystectomy	choleeystectomy	NN
cord-015021-pol2qm74	4160	44	.	.	.
cord-015021-pol2qm74	4161	1	Patients	patient	NNS
cord-015021-pol2qm74	4161	2	recruited	recruit	VBN
cord-015021-pol2qm74	4161	3	into	into	IN
cord-015021-pol2qm74	4161	4	our	-PRON-	PRP$
cord-015021-pol2qm74	4161	5	study	study	NN
cord-015021-pol2qm74	4161	6	had	have	VBD
cord-015021-pol2qm74	4161	7	experienced	experience	VBN
cord-015021-pol2qm74	4161	8	at	at	IN
cord-015021-pol2qm74	4161	9	least	least	RBS
cord-015021-pol2qm74	4161	10	one	one	CD
cord-015021-pol2qm74	4161	11	typical	typical	JJ
cord-015021-pol2qm74	4161	12	bifiary	bifiary	JJ
cord-015021-pol2qm74	4161	13	colic	colic	NN
cord-015021-pol2qm74	4161	14	,	,	,
cord-015021-pol2qm74	4161	15	had	have	VBD
cord-015021-pol2qm74	4161	16	ultrasound	ultrasound	NN
cord-015021-pol2qm74	4161	17	-	-	HYPH
cord-015021-pol2qm74	4161	18	proven	prove	VBN
cord-015021-pol2qm74	4161	19	cholelithiasis	cholelithiasis	NN
cord-015021-pol2qm74	4161	20	(	(	-LRB-
cord-015021-pol2qm74	4161	21	stages	stage	NNS
cord-015021-pol2qm74	4161	22	0-II	0-II	NFP
cord-015021-pol2qm74	4161	23	according	accord	VBG
cord-015021-pol2qm74	4161	24	to	to	IN
cord-015021-pol2qm74	4161	25	Me	Me	NNP
cord-015021-pol2qm74	4161	26	Sherry	Sherry	NNP
cord-015021-pol2qm74	4161	27	)	)	-RRB-
cord-015021-pol2qm74	4161	28	,	,	,
cord-015021-pol2qm74	4161	29	were	be	VBD
cord-015021-pol2qm74	4161	30	35	35	CD
cord-015021-pol2qm74	4161	31	-	-	SYM
cord-015021-pol2qm74	4161	32	55	55	CD
cord-015021-pol2qm74	4161	33	years	year	NNS
cord-015021-pol2qm74	4161	34	old	old	JJ
cord-015021-pol2qm74	4161	35	,	,	,
cord-015021-pol2qm74	4161	36	and	and	CC
cord-015021-pol2qm74	4161	37	presented	present	VBN
cord-015021-pol2qm74	4161	38	for	for	IN
cord-015021-pol2qm74	4161	39	elective	elective	JJ
cord-015021-pol2qm74	4161	40	choleeysteetomy	choleeysteetomy	NN
cord-015021-pol2qm74	4161	41	.	.	.
cord-015021-pol2qm74	4162	1	Patients	patient	NNS
cord-015021-pol2qm74	4162	2	could	could	MD
cord-015021-pol2qm74	4162	3	choose	choose	VB
cord-015021-pol2qm74	4162	4	between	between	IN
cord-015021-pol2qm74	4162	5	laparoscopic	laparoscopic	JJ
cord-015021-pol2qm74	4162	6	and	and	CC
cord-015021-pol2qm74	4162	7	conventional	conventional	JJ
cord-015021-pol2qm74	4162	8	eholeeystectomy	eholeeystectomy	NN
cord-015021-pol2qm74	4162	9	after	after	IN
cord-015021-pol2qm74	4162	10	being	be	VBG
cord-015021-pol2qm74	4162	11	informed	inform	VBN
cord-015021-pol2qm74	4162	12	about	about	IN
cord-015021-pol2qm74	4162	13	the	the	DT
cord-015021-pol2qm74	4162	14	advantages	advantage	NNS
cord-015021-pol2qm74	4162	15	and	and	CC
cord-015021-pol2qm74	4162	16	disadvantages	disadvantage	NNS
cord-015021-pol2qm74	4162	17	of	of	IN
cord-015021-pol2qm74	4162	18	each	each	DT
cord-015021-pol2qm74	4162	19	procedure	procedure	NN
cord-015021-pol2qm74	4162	20	.	.	.
cord-015021-pol2qm74	4163	1	Cell	cell	NN
cord-015021-pol2qm74	4163	2	surface	surface	NN
cord-015021-pol2qm74	4163	3	markers	marker	NNS
cord-015021-pol2qm74	4163	4	on	on	IN
cord-015021-pol2qm74	4163	5	leukoeytes	leukoeyte	NNS
cord-015021-pol2qm74	4163	6	were	be	VBD
cord-015021-pol2qm74	4163	7	determined	determine	VBN
cord-015021-pol2qm74	4163	8	using	use	VBG
cord-015021-pol2qm74	4163	9	whole	whole	JJ
cord-015021-pol2qm74	4163	10	blood	blood	NN
cord-015021-pol2qm74	4163	11	techniques	technique	NNS
cord-015021-pol2qm74	4163	12	with	with	IN
cord-015021-pol2qm74	4163	13	the	the	DT
cord-015021-pol2qm74	4163	14	help	help	NN
cord-015021-pol2qm74	4163	15	of	of	IN
cord-015021-pol2qm74	4163	16	commercially	commercially	RB
cord-015021-pol2qm74	4163	17	available	available	JJ
cord-015021-pol2qm74	4163	18	fluorescent	fluorescent	JJ
cord-015021-pol2qm74	4163	19	monocloml	monocloml	NNS
cord-015021-pol2qm74	4163	20	antibodies	antibody	NNS
cord-015021-pol2qm74	4163	21	and	and	CC
cord-015021-pol2qm74	4163	22	flow	flow	NN
cord-015021-pol2qm74	4163	23	cytometry	cytometry	NN
cord-015021-pol2qm74	4163	24	.	.	.
cord-015021-pol2qm74	4164	1	Shed	shed	JJ
cord-015021-pol2qm74	4164	2	cell	cell	NN
cord-015021-pol2qm74	4164	3	surface	surface	NN
cord-015021-pol2qm74	4164	4	markers	marker	NNS
cord-015021-pol2qm74	4164	5	in	in	IN
cord-015021-pol2qm74	4164	6	plasma	plasma	NN
cord-015021-pol2qm74	4164	7	and	and	CC
cord-015021-pol2qm74	4164	8	cytoldnes	cytoldne	NNS
cord-015021-pol2qm74	4164	9	were	be	VBD
cord-015021-pol2qm74	4164	10	measured	measure	VBN
cord-015021-pol2qm74	4164	11	with	with	IN
cord-015021-pol2qm74	4164	12	the	the	DT
cord-015021-pol2qm74	4164	13	help	help	NN
cord-015021-pol2qm74	4164	14	of	of	IN
cord-015021-pol2qm74	4164	15	sandwich	sandwich	NN
cord-015021-pol2qm74	4164	16	-	-	HYPH
cord-015021-pol2qm74	4164	17	ELISA	ELISA	NNP
cord-015021-pol2qm74	4164	18	kits	kit	NNS
cord-015021-pol2qm74	4164	19	.	.	.
cord-015021-pol2qm74	4165	1	Blood	blood	NN
cord-015021-pol2qm74	4165	2	samples	sample	NNS
cord-015021-pol2qm74	4165	3	were	be	VBD
cord-015021-pol2qm74	4165	4	drawn	draw	VBN
cord-015021-pol2qm74	4165	5	24	24	CD
cord-015021-pol2qm74	4165	6	h	h	NN
cord-015021-pol2qm74	4165	7	before	before	IN
cord-015021-pol2qm74	4165	8	surgery	surgery	NN
cord-015021-pol2qm74	4165	9	,	,	,
cord-015021-pol2qm74	4165	10	immediately	immediately	RB
cord-015021-pol2qm74	4165	11	before	before	IN
cord-015021-pol2qm74	4165	12	incision	incision	NN
cord-015021-pol2qm74	4165	13	(	(	-LRB-
cord-015021-pol2qm74	4165	14	after	after	IN
cord-015021-pol2qm74	4165	15	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4165	16	)	)	-RRB-
cord-015021-pol2qm74	4165	17	,	,	,
cord-015021-pol2qm74	4165	18	2	2	CD
cord-015021-pol2qm74	4165	19	h	h	NN
cord-015021-pol2qm74	4165	20	and	and	CC
cord-015021-pol2qm74	4165	21	24	24	CD
cord-015021-pol2qm74	4165	22	h	h	NN
cord-015021-pol2qm74	4165	23	after	after	IN
cord-015021-pol2qm74	4165	24	incision	incision	NN
cord-015021-pol2qm74	4165	25	.	.	.
cord-015021-pol2qm74	4166	1	Seventeen	seventeen	CD
cord-015021-pol2qm74	4166	2	cell	cell	NN
cord-015021-pol2qm74	4166	3	surface	surface	NN
cord-015021-pol2qm74	4166	4	markers	marker	NNS
cord-015021-pol2qm74	4166	5	were	be	VBD
cord-015021-pol2qm74	4166	6	examined	examine	VBN
cord-015021-pol2qm74	4166	7	on	on	IN
cord-015021-pol2qm74	4166	8	different	different	JJ
cord-015021-pol2qm74	4166	9	cell	cell	NN
cord-015021-pol2qm74	4166	10	populations	population	NNS
cord-015021-pol2qm74	4166	11	and	and	CC
cord-015021-pol2qm74	4166	12	cellular	cellular	JJ
cord-015021-pol2qm74	4166	13	subsets	subset	NNS
cord-015021-pol2qm74	4166	14	in	in	IN
cord-015021-pol2qm74	4166	15	18	18	CD
cord-015021-pol2qm74	4166	16	laparoscopic	laparoscopic	NNS
cord-015021-pol2qm74	4166	17	and	and	CC
cord-015021-pol2qm74	4166	18	15	15	CD
cord-015021-pol2qm74	4166	19	open	open	JJ
cord-015021-pol2qm74	4166	20	-	-	HYPH
cord-015021-pol2qm74	4166	21	surgery	surgery	NN
cord-015021-pol2qm74	4166	22	patients	patient	NNS
cord-015021-pol2qm74	4166	23	.	.	.
cord-015021-pol2qm74	4167	1	Three	three	CD
cord-015021-pol2qm74	4167	2	soluble	soluble	JJ
cord-015021-pol2qm74	4167	3	cell	cell	NN
cord-015021-pol2qm74	4167	4	surface	surface	NN
cord-015021-pol2qm74	4167	5	markers	marker	NNS
cord-015021-pol2qm74	4167	6	and	and	CC
cord-015021-pol2qm74	4167	7	six	six	CD
cord-015021-pol2qm74	4167	8	cytokines	cytokine	NNS
cord-015021-pol2qm74	4167	9	were	be	VBD
cord-015021-pol2qm74	4167	10	monitored	monitor	VBN
cord-015021-pol2qm74	4167	11	.	.	.
cord-015021-pol2qm74	4168	1	By	by	IN
cord-015021-pol2qm74	4168	2	statistical	statistical	JJ
cord-015021-pol2qm74	4168	3	analyses	analysis	NNS
cord-015021-pol2qm74	4168	4	(	(	-LRB-
cord-015021-pol2qm74	4168	5	multivariate	multivariate	JJ
cord-015021-pol2qm74	4168	6	regression	regression	NN
cord-015021-pol2qm74	4168	7	analysis	analysis	NN
cord-015021-pol2qm74	4168	8	,	,	,
cord-015021-pol2qm74	4168	9	Student	Student	NNP
cord-015021-pol2qm74	4168	10	's	's	POS
cord-015021-pol2qm74	4168	11	t	t	NN
cord-015021-pol2qm74	4168	12	test	test	NN
cord-015021-pol2qm74	4168	13	,	,	,
cord-015021-pol2qm74	4168	14	WilcoxomMann	WilcoxomMann	NNP
cord-015021-pol2qm74	4168	15	-	-	HYPH
cord-015021-pol2qm74	4168	16	Whituey	Whituey	NNP
cord-015021-pol2qm74	4168	17	's	's	POS
cord-015021-pol2qm74	4168	18	rank	rank	NN
cord-015021-pol2qm74	4168	19	sum	sum	NN
cord-015021-pol2qm74	4168	20	test	test	NN
cord-015021-pol2qm74	4168	21	)	)	-RRB-
cord-015021-pol2qm74	4168	22	the	the	DT
cord-015021-pol2qm74	4168	23	six	six	CD
cord-015021-pol2qm74	4168	24	markers	marker	NNS
cord-015021-pol2qm74	4168	25	/	/	SYM
cord-015021-pol2qm74	4168	26	cytekines	cytekine	NNS
cord-015021-pol2qm74	4168	27	that	that	WDT
cord-015021-pol2qm74	4168	28	best	well	RBS
cord-015021-pol2qm74	4168	29	distinguished	distinguished	JJ
cord-015021-pol2qm74	4168	30	open	open	JJ
cord-015021-pol2qm74	4168	31	surgical	surgical	NN
cord-015021-pol2qm74	4168	32	from	from	IN
cord-015021-pol2qm74	4168	33	laparoscopic	laparoscopic	JJ
cord-015021-pol2qm74	4168	34	procedurea	procedurea	NNP
cord-015021-pol2qm74	4168	35	were	be	VBD
cord-015021-pol2qm74	4168	36	determined	determine	VBN
cord-015021-pol2qm74	4168	37	.	.	.
cord-015021-pol2qm74	4169	1	These	these	DT
cord-015021-pol2qm74	4169	2	were	be	VBD
cord-015021-pol2qm74	4169	3	1	1	CD
cord-015021-pol2qm74	4169	4	.	.	.
cord-015021-pol2qm74	4170	1	the	the	DT
cord-015021-pol2qm74	4170	2	interleuldn-2	interleuldn-2	NNP
cord-015021-pol2qm74	4170	3	receptor	receptor	NN
cord-015021-pol2qm74	4170	4	and	and	CC
cord-015021-pol2qm74	4170	5	i	-PRON-	PRP
cord-015021-pol2qm74	4170	6	m	be	VBP
cord-015021-pol2qm74	4170	7	soluble	soluble	JJ
cord-015021-pol2qm74	4170	8	form	form	NN
cord-015021-pol2qm74	4170	9	(	(	-LRB-
cord-015021-pol2qm74	4170	10	CD25	CD25	NNP
cord-015021-pol2qm74	4170	11	/	/	SYM
cord-015021-pol2qm74	4170	12	sCD25	sCD25	NNP
cord-015021-pol2qm74	4170	13	)	)	-RRB-
cord-015021-pol2qm74	4170	14	;	;	:
cord-015021-pol2qm74	4170	15	2	2	CD
cord-015021-pol2qm74	4170	16	.	.	.
cord-015021-pol2qm74	4171	1	the	the	DT
cord-015021-pol2qm74	4171	2	activation	activation	NN
cord-015021-pol2qm74	4171	3	antigen	antigen	NN
cord-015021-pol2qm74	4171	4	Fd-1	Fd-1	NNP
cord-015021-pol2qm74	4171	5	and	and	CC
cord-015021-pol2qm74	4171	6	its	-PRON-	PRP$
cord-015021-pol2qm74	4171	7	soluble	soluble	JJ
cord-015021-pol2qm74	4171	8	form	form	NN
cord-015021-pol2qm74	4171	9	(	(	-LRB-
cord-015021-pol2qm74	4171	10	CD30	CD30	NNP
cord-015021-pol2qm74	4171	11	/	/	SYM
cord-015021-pol2qm74	4171	12	sCD30	sCD30	NNP
cord-015021-pol2qm74	4171	13	)	)	-RRB-
cord-015021-pol2qm74	4171	14	,	,	,
cord-015021-pol2qm74	4171	15	a	a	DT
cord-015021-pol2qm74	4171	16	member	member	NN
cord-015021-pol2qm74	4171	17	of	of	IN
cord-015021-pol2qm74	4171	18	the	the	DT
cord-015021-pol2qm74	4171	19	nerve	nerve	NN
cord-015021-pol2qm74	4171	20	-	-	HYPH
cord-015021-pol2qm74	4171	21	growth	growth	NN
cord-015021-pol2qm74	4171	22	-	-	HYPH
cord-015021-pol2qm74	4171	23	factor	factor	NN
cord-015021-pol2qm74	4171	24	receptor	receptor	NN
cord-015021-pol2qm74	4171	25	family	family	NN
cord-015021-pol2qm74	4171	26	;	;	:
cord-015021-pol2qm74	4171	27	3	3	CD
cord-015021-pol2qm74	4171	28	.	.	.
cord-015021-pol2qm74	4172	1	the	the	DT
cord-015021-pol2qm74	4172	2	CD45RO	CD45RO	NNP
cord-015021-pol2qm74	4172	3	epitope	epitope	NN
cord-015021-pol2qm74	4172	4	which	which	WDT
cord-015021-pol2qm74	4172	5	characterizes	characterize	VBZ
cord-015021-pol2qm74	4172	6	T	T	NNP
cord-015021-pol2qm74	4172	7	memory	memory	NN
cord-015021-pol2qm74	4172	8	ceils	ceil	NNS
cord-015021-pol2qm74	4172	9	;	;	:
cord-015021-pol2qm74	4172	10	4	4	CD
cord-015021-pol2qm74	4172	11	.	.	.
cord-015021-pol2qm74	4173	1	the	the	DT
cord-015021-pol2qm74	4173	2	trausferrin	trausferrin	NNP
cord-015021-pol2qm74	4173	3	receptor	receptor	NN
cord-015021-pol2qm74	4173	4	CD71	CD71	NNP
cord-015021-pol2qm74	4173	5	;	;	:
cord-015021-pol2qm74	4173	6	5	5	CD
cord-015021-pol2qm74	4173	7	.	.	.
cord-015021-pol2qm74	4174	1	the	the	DT
cord-015021-pol2qm74	4174	2	soluble	soluble	JJ
cord-015021-pol2qm74	4174	3	adhesion	adhesion	NN
cord-015021-pol2qm74	4174	4	molecule	molecule	NN
cord-015021-pol2qm74	4174	5	ICAM-1	icam-1	NN
cord-015021-pol2qm74	4174	6	;	;	:
cord-015021-pol2qm74	4174	7	and	and	CC
cord-015021-pol2qm74	4174	8	6	6	CD
cord-015021-pol2qm74	4174	9	.	.	.
cord-015021-pol2qm74	4175	1	the	the	DT
cord-015021-pol2qm74	4175	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	4175	3	interieukin-6	interieukin-6	NNPS
cord-015021-pol2qm74	4175	4	and	and	CC
cord-015021-pol2qm74	4175	5	interleuldn-8	interleuldn-8	NNP
cord-015021-pol2qm74	4175	6	.	.	.
cord-015021-pol2qm74	4176	1	On	on	IN
cord-015021-pol2qm74	4176	2	the	the	DT
cord-015021-pol2qm74	4176	3	basis	basis	NN
cord-015021-pol2qm74	4176	4	of	of	IN
cord-015021-pol2qm74	4176	5	these	these	DT
cord-015021-pol2qm74	4176	6	results	result	NNS
cord-015021-pol2qm74	4176	7	,	,	,
cord-015021-pol2qm74	4176	8	a	a	DT
cord-015021-pol2qm74	4176	9	tissue	tissue	NN
cord-015021-pol2qm74	4176	10	trauma	trauma	NN
cord-015021-pol2qm74	4176	11	activation	activation	NN
cord-015021-pol2qm74	4176	12	(	(	-LRB-
cord-015021-pol2qm74	4176	13	TTA	TTA	NNP
cord-015021-pol2qm74	4176	14	)	)	-RRB-
cord-015021-pol2qm74	4176	15	index	index	NN
cord-015021-pol2qm74	4176	16	was	be	VBD
cord-015021-pol2qm74	4176	17	calculated	calculate	VBN
cord-015021-pol2qm74	4176	18	by	by	IN
cord-015021-pol2qm74	4176	19	combining	combine	VBG
cord-015021-pol2qm74	4176	20	the	the	DT
cord-015021-pol2qm74	4176	21	marker	marker	NN
cord-015021-pol2qm74	4176	22	/	/	SYM
cord-015021-pol2qm74	4176	23	cytoldne	cytoldne	NN
cord-015021-pol2qm74	4176	24	measurements	measurement	NNS
cord-015021-pol2qm74	4176	25	by	by	IN
cord-015021-pol2qm74	4176	26	simple	simple	JJ
cord-015021-pol2qm74	4176	27	multiplication	multiplication	NN
cord-015021-pol2qm74	4176	28	.	.	.
cord-015021-pol2qm74	4177	1	Anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4177	2	and	and	CC
cord-015021-pol2qm74	4177	3	pre	pre	JJ
cord-015021-pol2qm74	4177	4	-	-	JJ
cord-015021-pol2qm74	4177	5	ineision	ineision	JJ
cord-015021-pol2qm74	4177	6	maneuvers	maneuver	NNS
cord-015021-pol2qm74	4177	7	did	do	VBD
cord-015021-pol2qm74	4177	8	not	not	RB
cord-015021-pol2qm74	4177	9	significantly	significantly	RB
cord-015021-pol2qm74	4177	10	change	change	VB
cord-015021-pol2qm74	4177	11	cell	cell	NN
cord-015021-pol2qm74	4177	12	marker	marker	NN
cord-015021-pol2qm74	4177	13	or	or	CC
cord-015021-pol2qm74	4177	14	cytokine	cytokine	NN
cord-015021-pol2qm74	4177	15	levels	level	NNS
cord-015021-pol2qm74	4177	16	in	in	IN
cord-015021-pol2qm74	4177	17	either	either	CC
cord-015021-pol2qm74	4177	18	surgical	surgical	JJ
cord-015021-pol2qm74	4177	19	approach	approach	NN
cord-015021-pol2qm74	4177	20	as	as	IN
cord-015021-pol2qm74	4177	21	compared	compare	VBN
cord-015021-pol2qm74	4177	22	to	to	IN
cord-015021-pol2qm74	4177	23	24	24	CD
cord-015021-pol2qm74	4177	24	h	h	NN
cord-015021-pol2qm74	4177	25	before	before	IN
cord-015021-pol2qm74	4177	26	surgery	surgery	NN
cord-015021-pol2qm74	4177	27	.	.	.
cord-015021-pol2qm74	4178	1	2	2	LS
cord-015021-pol2qm74	4178	2	h	h	NN
cord-015021-pol2qm74	4178	3	after	after	IN
cord-015021-pol2qm74	4178	4	incision	incision	NN
cord-015021-pol2qm74	4178	5	the	the	DT
cord-015021-pol2qm74	4178	6	TrA	TrA	NNP
cord-015021-pol2qm74	4178	7	index	index	NN
cord-015021-pol2qm74	4178	8	in	in	IN
cord-015021-pol2qm74	4178	9	open	open	JJ
cord-015021-pol2qm74	4178	10	cholecystectomy	cholecystectomy	NN
cord-015021-pol2qm74	4178	11	showed	show	VBD
cord-015021-pol2qm74	4178	12	a	a	DT
cord-015021-pol2qm74	4178	13	distinct	distinct	JJ
cord-015021-pol2qm74	4178	14	22	22	CD
cord-015021-pol2qm74	4178	15	-	-	SYM
cord-015021-pol2qm74	4178	16	37	37	CD
cord-015021-pol2qm74	4178	17	fold	fold	JJ
cord-015021-pol2qm74	4178	18	increase	increase	NN
cord-015021-pol2qm74	4178	19	,	,	,
cord-015021-pol2qm74	4178	20	whereas	whereas	IN
cord-015021-pol2qm74	4178	21	in	in	IN
cord-015021-pol2qm74	4178	22	laparoseopic	laparoseopic	NNP
cord-015021-pol2qm74	4178	23	surgery	surgery	NN
cord-015021-pol2qm74	4178	24	a	a	DT
cord-015021-pol2qm74	4178	25	mere	mere	JJ
cord-015021-pol2qm74	4178	26	2	2	CD
cord-015021-pol2qm74	4178	27	-	-	SYM
cord-015021-pol2qm74	4178	28	3	3	CD
cord-015021-pol2qm74	4178	29	fold	fold	JJ
cord-015021-pol2qm74	4178	30	increase	increase	NN
cord-015021-pol2qm74	4178	31	was	be	VBD
cord-015021-pol2qm74	4178	32	noted	note	VBN
cord-015021-pol2qm74	4178	33	.	.	.
cord-015021-pol2qm74	4179	1	24	24	CD
cord-015021-pol2qm74	4179	2	h	h	NN
cord-015021-pol2qm74	4179	3	after	after	IN
cord-015021-pol2qm74	4179	4	incision	incision	NN
cord-015021-pol2qm74	4179	5	,	,	,
cord-015021-pol2qm74	4179	6	the	the	DT
cord-015021-pol2qm74	4179	7	TrA	tra	NN
cord-015021-pol2qm74	4179	8	-	-	HYPH
cord-015021-pol2qm74	4179	9	index	index	NN
cord-015021-pol2qm74	4179	10	returned	return	VBD
cord-015021-pol2qm74	4179	11	to	to	IN
cord-015021-pol2qm74	4179	12	near	near	IN
cord-015021-pol2qm74	4179	13	pre	pre	JJ
cord-015021-pol2qm74	4179	14	-	-	JJ
cord-015021-pol2qm74	4179	15	surgery	surgery	JJ
cord-015021-pol2qm74	4179	16	levels	level	NNS
cord-015021-pol2qm74	4179	17	.	.	.
cord-015021-pol2qm74	4180	1	In	in	IN
cord-015021-pol2qm74	4180	2	conclusion	conclusion	NN
cord-015021-pol2qm74	4180	3	,	,	,
cord-015021-pol2qm74	4180	4	our	-PRON-	PRP$
cord-015021-pol2qm74	4180	5	results	result	NNS
cord-015021-pol2qm74	4180	6	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	4180	7	that	that	IN
cord-015021-pol2qm74	4180	8	changes	change	NNS
cord-015021-pol2qm74	4180	9	in	in	IN
cord-015021-pol2qm74	4180	10	cell	cell	NN
cord-015021-pol2qm74	4180	11	surface	surface	NN
cord-015021-pol2qm74	4180	12	markers	marker	NNS
cord-015021-pol2qm74	4180	13	and	and	CC
cord-015021-pol2qm74	4180	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	4180	15	can	can	MD
cord-015021-pol2qm74	4180	16	help	help	VB
cord-015021-pol2qm74	4180	17	evaluate	evaluate	VB
cord-015021-pol2qm74	4180	18	the	the	DT
cord-015021-pol2qm74	4180	19	magnitude	magnitude	NN
cord-015021-pol2qm74	4180	20	of	of	IN
cord-015021-pol2qm74	4180	21	tissue	tissue	NN
cord-015021-pol2qm74	4180	22	trauma	trauma	NN
cord-015021-pol2qm74	4180	23	in	in	IN
cord-015021-pol2qm74	4180	24	diffei'ent	diffei'ent	JJ
cord-015021-pol2qm74	4180	25	surgical	surgical	JJ
cord-015021-pol2qm74	4180	26	approaches	approach	NNS
cord-015021-pol2qm74	4180	27	.	.	.
cord-015021-pol2qm74	4181	1	The	the	DT
cord-015021-pol2qm74	4181	2	relationship	relationship	NN
cord-015021-pol2qm74	4181	3	between	between	IN
cord-015021-pol2qm74	4181	4	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4181	5	subpopulation	subpopulation	NN
cord-015021-pol2qm74	4181	6	changes	change	NNS
cord-015021-pol2qm74	4181	7	after	after	IN
cord-015021-pol2qm74	4181	8	thermal	thermal	JJ
cord-015021-pol2qm74	4181	9	injury	injury	NN
cord-015021-pol2qm74	4181	10	and	and	CC
cord-015021-pol2qm74	4181	11	the	the	DT
cord-015021-pol2qm74	4181	12	increased	increase	VBN
cord-015021-pol2qm74	4181	13	susceptibility	susceptibility	NN
cord-015021-pol2qm74	4181	14	of	of	IN
cord-015021-pol2qm74	4181	15	burned	burn	VBN
cord-015021-pol2qm74	4181	16	patients	patient	NNS
cord-015021-pol2qm74	4181	17	to	to	IN
cord-015021-pol2qm74	4181	18	infection	infection	NN
cord-015021-pol2qm74	4181	19	is	be	VBZ
cord-015021-pol2qm74	4181	20	unclear	unclear	JJ
cord-015021-pol2qm74	4181	21	.	.	.
cord-015021-pol2qm74	4182	1	In	in	IN
cord-015021-pol2qm74	4182	2	this	this	DT
cord-015021-pol2qm74	4182	3	study	study	NN
cord-015021-pol2qm74	4182	4	,	,	,
cord-015021-pol2qm74	4182	5	we	-PRON-	PRP
cord-015021-pol2qm74	4182	6	have	have	VBP
cord-015021-pol2qm74	4182	7	attempted	attempt	VBN
cord-015021-pol2qm74	4182	8	to	to	TO
cord-015021-pol2qm74	4182	9	correlate	correlate	VB
cord-015021-pol2qm74	4182	10	such	such	JJ
cord-015021-pol2qm74	4182	11	subpopulation	subpopulation	NN
cord-015021-pol2qm74	4182	12	changes	change	NNS
cord-015021-pol2qm74	4182	13	with	with	IN
cord-015021-pol2qm74	4182	14	the	the	DT
cord-015021-pol2qm74	4182	15	presence	presence	NN
cord-015021-pol2qm74	4182	16	of	of	IN
cord-015021-pol2qm74	4182	17	infection	infection	NN
cord-015021-pol2qm74	4182	18	in	in	IN
cord-015021-pol2qm74	4182	19	burned	burn	VBN
cord-015021-pol2qm74	4182	20	patients	patient	NNS
cord-015021-pol2qm74	4182	21	.	.	.
cord-015021-pol2qm74	4183	1	Peripberal	peripberal	JJ
cord-015021-pol2qm74	4183	2	blood	blood	NN
cord-015021-pol2qm74	4183	3	from	from	IN
cord-015021-pol2qm74	4183	4	19	19	CD
cord-015021-pol2qm74	4183	5	patients	patient	NNS
cord-015021-pol2qm74	4183	6	was	be	VBD
cord-015021-pol2qm74	4183	7	monitored	monitor	VBN
cord-015021-pol2qm74	4183	8	for	for	IN
cord-015021-pol2qm74	4183	9	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4183	10	subpopulation	subpopulation	NN
cord-015021-pol2qm74	4183	11	changes	change	VBZ
cord-015021-pol2qm74	4183	12	three	three	CD
cord-015021-pol2qm74	4183	13	times	time	NNS
cord-015021-pol2qm74	4183	14	weekly	weekly	JJ
cord-015021-pol2qm74	4183	15	for	for	IN
cord-015021-pol2qm74	4183	16	three	three	CD
cord-015021-pol2qm74	4183	17	weeks	week	NNS
cord-015021-pol2qm74	4183	18	postburn	postburn	NN
cord-015021-pol2qm74	4183	19	and	and	CC
cord-015021-pol2qm74	4183	20	weekly	weekly	NN
cord-015021-pol2qm74	4183	21	thereafter	thereafter	RB
cord-015021-pol2qm74	4183	22	for	for	IN
cord-015021-pol2qm74	4183	23	three	three	CD
cord-015021-pol2qm74	4183	24	additional	additional	JJ
cord-015021-pol2qm74	4183	25	weeks	week	NNS
cord-015021-pol2qm74	4183	26	.	.	.
cord-015021-pol2qm74	4184	1	Mean	mean	VB
cord-015021-pol2qm74	4184	2	bum	bum	JJ
cord-015021-pol2qm74	4184	3	size	size	NN
cord-015021-pol2qm74	4184	4	was	be	VBD
cord-015021-pol2qm74	4184	5	44.7	44.7	CD
cord-015021-pol2qm74	4184	6	%	%	NN
cord-015021-pol2qm74	4184	7	(	(	-LRB-
cord-015021-pol2qm74	4184	8	range	range	NN
cord-015021-pol2qm74	4184	9	24%-84	24%-84	CD
cord-015021-pol2qm74	4184	10	%	%	NN
cord-015021-pol2qm74	4184	11	)	)	-RRB-
cord-015021-pol2qm74	4184	12	of	of	IN
cord-015021-pol2qm74	4184	13	total	total	JJ
cord-015021-pol2qm74	4184	14	body	body	NN
cord-015021-pol2qm74	4184	15	surface	surface	NN
cord-015021-pol2qm74	4184	16	and	and	CC
cord-015021-pol2qm74	4184	17	mean	mean	VB
cord-015021-pol2qm74	4184	18	age	age	NN
cord-015021-pol2qm74	4184	19	was	be	VBD
cord-015021-pol2qm74	4184	20	38	38	CD
cord-015021-pol2qm74	4184	21	years	year	NNS
cord-015021-pol2qm74	4184	22	.	.	.
cord-015021-pol2qm74	4185	1	Infection	infection	NN
cord-015021-pol2qm74	4185	2	was	be	VBD
cord-015021-pol2qm74	4185	3	diagnosed	diagnose	VBN
cord-015021-pol2qm74	4185	4	by	by	IN
cord-015021-pol2qm74	4185	5	carefully	carefully	RB
cord-015021-pol2qm74	4185	6	defined	define	VBN
cord-015021-pol2qm74	4185	7	clinical	clinical	JJ
cord-015021-pol2qm74	4185	8	and	and	CC
cord-015021-pol2qm74	4185	9	laboratory	laboratory	NN
cord-015021-pol2qm74	4185	10	criteria	criterion	NNS
cord-015021-pol2qm74	4185	11	and	and	CC
cord-015021-pol2qm74	4185	12	its	-PRON-	PRP$
cord-015021-pol2qm74	4185	13	presence	presence	NN
cord-015021-pol2qm74	4185	14	or	or	CC
cord-015021-pol2qm74	4185	15	absence	absence	NN
cord-015021-pol2qm74	4185	16	noted	note	VBD
cord-015021-pol2qm74	4185	17	each	each	DT
cord-015021-pol2qm74	4185	18	time	time	NN
cord-015021-pol2qm74	4185	19	blood	blood	NN
cord-015021-pol2qm74	4185	20	was	be	VBD
cord-015021-pol2qm74	4185	21	drawn	draw	VBN
cord-015021-pol2qm74	4185	22	.	.	.
cord-015021-pol2qm74	4186	1	Samples	sample	NNS
cord-015021-pol2qm74	4186	2	taken	take	VBN
cord-015021-pol2qm74	4186	3	when	when	WRB
cord-015021-pol2qm74	4186	4	patients	patient	NNS
cord-015021-pol2qm74	4186	5	had	have	VBD
cord-015021-pol2qm74	4186	6	wound	wind	VBN
cord-015021-pol2qm74	4186	7	infection	infection	NN
cord-015021-pol2qm74	4186	8	,	,	,
cord-015021-pol2qm74	4186	9	bacteremia	bacteremia	NN
cord-015021-pol2qm74	4186	10	,	,	,
cord-015021-pol2qm74	4186	11	or	or	CC
cord-015021-pol2qm74	4186	12	pneumonia	pneumonia	NN
cord-015021-pol2qm74	4186	13	were	be	VBD
cord-015021-pol2qm74	4186	14	compared	compare	VBN
cord-015021-pol2qm74	4186	15	with	with	IN
cord-015021-pol2qm74	4186	16	samples	sample	NNS
cord-015021-pol2qm74	4186	17	taken	take	VBN
cord-015021-pol2qm74	4186	18	in	in	IN
cord-015021-pol2qm74	4186	19	the	the	DT
cord-015021-pol2qm74	4186	20	absence	absence	NN
cord-015021-pol2qm74	4186	21	of	of	IN
cord-015021-pol2qm74	4186	22	systemic	systemic	JJ
cord-015021-pol2qm74	4186	23	infection	infection	NN
cord-015021-pol2qm74	4186	24	.	.	.
cord-015021-pol2qm74	4187	1	Whole	whole	JJ
cord-015021-pol2qm74	4187	2	blood	blood	NN
cord-015021-pol2qm74	4187	3	samples	sample	NNS
cord-015021-pol2qm74	4187	4	were	be	VBD
cord-015021-pol2qm74	4187	5	stained	stain	VBN
cord-015021-pol2qm74	4187	6	with	with	IN
cord-015021-pol2qm74	4187	7	four	four	CD
cord-015021-pol2qm74	4187	8	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	4187	9	antibodies	antibody	NNS
cord-015021-pol2qm74	4187	10	,	,	,
cord-015021-pol2qm74	4187	11	the	the	DT
cord-015021-pol2qm74	4187	12	red	red	JJ
cord-015021-pol2qm74	4187	13	blood	blood	NN
cord-015021-pol2qm74	4187	14	cells	cell	NNS
cord-015021-pol2qm74	4187	15	lysed	lyse	VBN
cord-015021-pol2qm74	4187	16	and	and	CC
cord-015021-pol2qm74	4187	17	the	the	DT
cord-015021-pol2qm74	4187	18	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	4187	19	fixed	fix	VBN
cord-015021-pol2qm74	4187	20	and	and	CC
cord-015021-pol2qm74	4187	21	analyzed	analyze	VBN
cord-015021-pol2qm74	4187	22	by	by	IN
cord-015021-pol2qm74	4187	23	flow	flow	NN
cord-015021-pol2qm74	4187	24	cytometry	cytometry	NN
cord-015021-pol2qm74	4187	25	.	.	.
cord-015021-pol2qm74	4188	1	For	for	IN
cord-015021-pol2qm74	4188	2	each	each	DT
cord-015021-pol2qm74	4188	3	patient	patient	JJ
cord-015021-pol2qm74	4188	4	sample	sample	NN
cord-015021-pol2qm74	4188	5	,	,	,
cord-015021-pol2qm74	4188	6	the	the	DT
cord-015021-pol2qm74	4188	7	proportion	proportion	NN
cord-015021-pol2qm74	4188	8	of	of	IN
cord-015021-pol2qm74	4188	9	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4188	10	falling	fall	VBG
cord-015021-pol2qm74	4188	11	within	within	IN
cord-015021-pol2qm74	4188	12	the	the	DT
cord-015021-pol2qm74	4188	13	light	light	JJ
cord-015021-pol2qm74	4188	14	scatter	scatter	NN
cord-015021-pol2qm74	4188	15	gates	gate	NNS
cord-015021-pol2qm74	4188	16	was	be	VBD
cord-015021-pol2qm74	4188	17	determined	determine	VBN
cord-015021-pol2qm74	4188	18	as	as	IN
cord-015021-pol2qm74	4188	19	the	the	DT
cord-015021-pol2qm74	4188	20	percentage	percentage	NN
cord-015021-pol2qm74	4188	21	of	of	IN
cord-015021-pol2qm74	4188	22	cells	cell	NNS
cord-015021-pol2qm74	4188	23	negative	negative	JJ
cord-015021-pol2qm74	4188	24	for	for	IN
cord-015021-pol2qm74	4188	25	CD14	CD14	NNP
cord-015021-pol2qm74	4188	26	and	and	CC
cord-015021-pol2qm74	4188	27	most	most	RBS
cord-015021-pol2qm74	4188	28	strongly	strongly	RB
cord-015021-pol2qm74	4188	29	positive	positive	JJ
cord-015021-pol2qm74	4188	30	for	for	IN
cord-015021-pol2qm74	4188	31	CD45	CD45	NNP
cord-015021-pol2qm74	4188	32	.	.	.
cord-015021-pol2qm74	4189	1	This	this	DT
cord-015021-pol2qm74	4189	2	percentage	percentage	NN
cord-015021-pol2qm74	4189	3	was	be	VBD
cord-015021-pol2qm74	4189	4	used	use	VBN
cord-015021-pol2qm74	4189	5	to	to	TO
cord-015021-pol2qm74	4189	6	correct	correct	VB
cord-015021-pol2qm74	4189	7	each	each	DT
cord-015021-pol2qm74	4189	8	sample	sample	NN
cord-015021-pol2qm74	4189	9	for	for	IN
cord-015021-pol2qm74	4189	10	the	the	DT
cord-015021-pol2qm74	4189	11	presence	presence	NN
cord-015021-pol2qm74	4189	12	of	of	IN
cord-015021-pol2qm74	4189	13	debris	debris	NN
cord-015021-pol2qm74	4189	14	or	or	CC
cord-015021-pol2qm74	4189	15	nonlymphocytic	nonlymphocytic	NN
cord-015021-pol2qm74	4189	16	cells	cell	NNS
cord-015021-pol2qm74	4189	17	.	.	.
cord-015021-pol2qm74	4190	1	The	the	DT
cord-015021-pol2qm74	4190	2	proportion	proportion	NN
cord-015021-pol2qm74	4190	3	of	of	IN
cord-015021-pol2qm74	4190	4	CD4	CD4	NNP
cord-015021-pol2qm74	4190	5	and	and	CC
cord-015021-pol2qm74	4190	6	CD8	CD8	NNP
cord-015021-pol2qm74	4190	7	positive	positive	JJ
cord-015021-pol2qm74	4190	8	cells	cell	NNS
cord-015021-pol2qm74	4190	9	was	be	VBD
cord-015021-pol2qm74	4190	10	slightly	slightly	RB
cord-015021-pol2qm74	4190	11	greatc~	greatc~	NNS
cord-015021-pol2qm74	4190	12	in	in	IN
cord-015021-pol2qm74	4190	13	the	the	DT
cord-015021-pol2qm74	4190	14	samples	sample	NNS
cord-015021-pol2qm74	4190	15	from	from	IN
cord-015021-pol2qm74	4190	16	infected	infected	JJ
cord-015021-pol2qm74	4190	17	patients	patient	NNS
cord-015021-pol2qm74	4190	18	,	,	,
cord-015021-pol2qm74	4190	19	while	while	IN
cord-015021-pol2qm74	4190	20	the	the	DT
cord-015021-pol2qm74	4190	21	proportion	proportion	NN
cord-015021-pol2qm74	4190	22	of	of	IN
cord-015021-pol2qm74	4190	23	B	b	NN
cord-015021-pol2qm74	4190	24	cells	cell	NNS
cord-015021-pol2qm74	4190	25	(	(	-LRB-
cord-015021-pol2qm74	4190	26	CD20	cd20	NN
cord-015021-pol2qm74	4190	27	+	+	CC
cord-015021-pol2qm74	4190	28	)	)	-RRB-
cord-015021-pol2qm74	4190	29	was	be	VBD
cord-015021-pol2qm74	4190	30	unchanged	unchanged	JJ
cord-015021-pol2qm74	4190	31	and	and	CC
cord-015021-pol2qm74	4190	32	NK	NK	NNP
cord-015021-pol2qm74	4190	33	(	(	-LRB-
cord-015021-pol2qm74	4190	34	CD16	CD16	NNP
cord-015021-pol2qm74	4190	35	+	+	SYM
cord-015021-pol2qm74	4190	36	)	)	-RRB-
cord-015021-pol2qm74	4190	37	cells	cell	NNS
cord-015021-pol2qm74	4190	38	were	be	VBD
cord-015021-pol2qm74	4190	39	decreased	decrease	VBN
cord-015021-pol2qm74	4190	40	by	by	IN
cord-015021-pol2qm74	4190	41	ahnos	ahnos	NNP
cord-015021-pol2qm74	4190	42	[	[	-LRB-
cord-015021-pol2qm74	4190	43	50	50	CD
cord-015021-pol2qm74	4190	44	%	%	NN
cord-015021-pol2qm74	4190	45	compared	compare	VBN
cord-015021-pol2qm74	4190	46	to	to	IN
cord-015021-pol2qm74	4190	47	sampie~	sampie~	NNP
cord-015021-pol2qm74	4190	48	li'om	li'om	NNP
cord-015021-pol2qm74	4190	49	uuiuleclcd	uuiuleclcd	NNP
cord-015021-pol2qm74	4190	50	patients	patient	NNS
cord-015021-pol2qm74	4190	51	.	.	.
cord-015021-pol2qm74	4191	1	The	the	DT
cord-015021-pol2qm74	4191	2	percentage	percentage	NN
cord-015021-pol2qm74	4191	3	of	of	IN
cord-015021-pol2qm74	4191	4	cells	cell	NNS
cord-015021-pol2qm74	4191	5	positive	positive	JJ
cord-015021-pol2qm74	4191	6	for	for	IN
cord-015021-pol2qm74	4191	7	CDIlb	CDIlb	NNP
cord-015021-pol2qm74	4191	8	(	(	-LRB-
cord-015021-pol2qm74	4191	9	c~	c~	IN
cord-015021-pol2qm74	4191	10	integrin	integrin	NN
cord-015021-pol2qm74	4191	11	)	)	-RRB-
cord-015021-pol2qm74	4191	12	decreased	decrease	VBD
cord-015021-pol2qm74	4191	13	sharply	sharply	RB
cord-015021-pol2qm74	4191	14	and	and	CC
cord-015021-pol2qm74	4191	15	CD4RO	cd4ro	JJ
cord-015021-pol2qm74	4191	16	(	(	-LRB-
cord-015021-pol2qm74	4191	17	memory	memory	NN
cord-015021-pol2qm74	4191	18	cells	cell	NNS
cord-015021-pol2qm74	4191	19	)	)	-RRB-
cord-015021-pol2qm74	4191	20	decreased	decrease	VBD
cord-015021-pol2qm74	4191	21	slightly	slightly	RB
cord-015021-pol2qm74	4191	22	in	in	IN
cord-015021-pol2qm74	4191	23	samples	sample	NNS
cord-015021-pol2qm74	4191	24	from	from	IN
cord-015021-pol2qm74	4191	25	infected	infected	JJ
cord-015021-pol2qm74	4191	26	patients	patient	NNS
cord-015021-pol2qm74	4191	27	while	while	IN
cord-015021-pol2qm74	4191	28	the	the	DT
cord-015021-pol2qm74	4191	29	expression	expression	NN
cord-015021-pol2qm74	4191	30	of	of	IN
cord-015021-pol2qm74	4191	31	the	the	DT
cord-015021-pol2qm74	4191	32	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4191	33	homing	homing	NN
cord-015021-pol2qm74	4191	34	receptor	receptor	NN
cord-015021-pol2qm74	4191	35	and	and	CC
cord-015021-pol2qm74	4191	36	CD29	CD29	NNP
cord-015021-pol2qm74	4191	37	were	be	VBD
cord-015021-pol2qm74	4191	38	unchanged	unchanged	JJ
cord-015021-pol2qm74	4191	39	.	.	.
cord-015021-pol2qm74	4192	1	CD25	cd25	JJ
cord-015021-pol2qm74	4192	2	(	(	-LRB-
cord-015021-pol2qm74	4192	3	IL2	IL2	NNP
cord-015021-pol2qm74	4192	4	receptor	receptor	NN
cord-015021-pol2qm74	4192	5	)	)	-RRB-
cord-015021-pol2qm74	4192	6	and	and	CC
cord-015021-pol2qm74	4192	7	CD69	CD69	NNP
cord-015021-pol2qm74	4192	8	(	(	-LRB-
cord-015021-pol2qm74	4192	9	early	early	JJ
cord-015021-pol2qm74	4192	10	activation	activation	NN
cord-015021-pol2qm74	4192	11	marker	marker	NN
cord-015021-pol2qm74	4192	12	)	)	-RRB-
cord-015021-pol2qm74	4192	13	were	be	VBD
cord-015021-pol2qm74	4192	14	significantly	significantly	RB
cord-015021-pol2qm74	4192	15	increased	increase	VBN
cord-015021-pol2qm74	4192	16	in	in	IN
cord-015021-pol2qm74	4192	17	the	the	DT
cord-015021-pol2qm74	4192	18	samples	sample	NNS
cord-015021-pol2qm74	4192	19	from	from	IN
cord-015021-pol2qm74	4192	20	the	the	DT
cord-015021-pol2qm74	4192	21	infected	infected	JJ
cord-015021-pol2qm74	4192	22	patients	patient	NNS
cord-015021-pol2qm74	4192	23	while	while	IN
cord-015021-pol2qm74	4192	24	HLADR	HLADR	NNP
cord-015021-pol2qm74	4192	25	was	be	VBD
cord-015021-pol2qm74	4192	26	unchanged	unchanged	JJ
cord-015021-pol2qm74	4192	27	.	.	.
cord-015021-pol2qm74	4193	1	These	these	DT
cord-015021-pol2qm74	4193	2	changes	change	NNS
cord-015021-pol2qm74	4193	3	in	in	IN
cord-015021-pol2qm74	4193	4	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4193	5	phenotype	phenotype	NN
cord-015021-pol2qm74	4193	6	correlate	correlate	VBP
cord-015021-pol2qm74	4193	7	with	with	IN
cord-015021-pol2qm74	4193	8	the	the	DT
cord-015021-pol2qm74	4193	9	presence	presence	NN
cord-015021-pol2qm74	4193	10	of	of	IN
cord-015021-pol2qm74	4193	11	infection	infection	NN
cord-015021-pol2qm74	4193	12	.	.	.
cord-015021-pol2qm74	4194	1	If	if	IN
cord-015021-pol2qm74	4194	2	they	-PRON-	PRP
cord-015021-pol2qm74	4194	3	closely	closely	RB
cord-015021-pol2qm74	4194	4	precede	precede	VBP
cord-015021-pol2qm74	4194	5	or	or	CC
cord-015021-pol2qm74	4194	6	occur	occur	VBP
cord-015021-pol2qm74	4194	7	during	during	IN
cord-015021-pol2qm74	4194	8	the	the	DT
cord-015021-pol2qm74	4194	9	early	early	JJ
cord-015021-pol2qm74	4194	10	development	development	NN
cord-015021-pol2qm74	4194	11	of	of	IN
cord-015021-pol2qm74	4194	12	infection	infection	NN
cord-015021-pol2qm74	4194	13	they	-PRON-	PRP
cord-015021-pol2qm74	4194	14	may	may	MD
cord-015021-pol2qm74	4194	15	be	be	VB
cord-015021-pol2qm74	4194	16	valuable	valuable	JJ
cord-015021-pol2qm74	4194	17	clues	clue	NNS
cord-015021-pol2qm74	4194	18	to	to	IN
cord-015021-pol2qm74	4194	19	the	the	DT
cord-015021-pol2qm74	4194	20	mechanism	mechanism	NN
cord-015021-pol2qm74	4194	21	of	of	IN
cord-015021-pol2qm74	4194	22	susceptibility	susceptibility	NN
cord-015021-pol2qm74	4194	23	following	follow	VBG
cord-015021-pol2qm74	4194	24	thermal	thermal	JJ
cord-015021-pol2qm74	4194	25	injury	injury	NN
cord-015021-pol2qm74	4194	26	.	.	.
cord-015021-pol2qm74	4195	1	Trauma	trauma	NN
cord-015021-pol2qm74	4195	2	patients	patient	NNS
cord-015021-pol2qm74	4195	3	are	be	VBP
cord-015021-pol2qm74	4195	4	subjected	subject	VBN
cord-015021-pol2qm74	4195	5	to	to	IN
cord-015021-pol2qm74	4195	6	an	an	DT
cord-015021-pol2qm74	4195	7	immediate	immediate	JJ
cord-015021-pol2qm74	4195	8	massive	massive	JJ
cord-015021-pol2qm74	4195	9	impact	impact	NN
cord-015021-pol2qm74	4195	10	on	on	IN
cord-015021-pol2qm74	4195	11	their	-PRON-	PRP$
cord-015021-pol2qm74	4195	12	host	host	NN
cord-015021-pol2qm74	4195	13	defense	defense	NN
cord-015021-pol2qm74	4195	14	integrity	integrity	NN
cord-015021-pol2qm74	4195	15	due	due	IN
cord-015021-pol2qm74	4195	16	to	to	IN
cord-015021-pol2qm74	4195	17	the	the	DT
cord-015021-pol2qm74	4195	18	combined	combined	JJ
cord-015021-pol2qm74	4195	19	effect	effect	NN
cord-015021-pol2qm74	4195	20	of	of	IN
cord-015021-pol2qm74	4195	21	tissue	tissue	NN
cord-015021-pol2qm74	4195	22	trauma	trauma	NN
cord-015021-pol2qm74	4195	23	,	,	,
cord-015021-pol2qm74	4195	24	shock	shock	NN
cord-015021-pol2qm74	4195	25	and	and	CC
cord-015021-pol2qm74	4195	26	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4195	27	.	.	.
cord-015021-pol2qm74	4196	1	Cytoldnes	cytoldne	NNS
cord-015021-pol2qm74	4196	2	are	be	VBP
cord-015021-pol2qm74	4196	3	playing	play	VBG
cord-015021-pol2qm74	4196	4	a	a	DT
cord-015021-pol2qm74	4196	5	crucial	crucial	JJ
cord-015021-pol2qm74	4196	6	role	role	NN
cord-015021-pol2qm74	4196	7	within	within	IN
cord-015021-pol2qm74	4196	8	the	the	DT
cord-015021-pol2qm74	4196	9	course	course	NN
cord-015021-pol2qm74	4196	10	of	of	IN
cord-015021-pol2qm74	4196	11	an	an	DT
cord-015021-pol2qm74	4196	12	impaired	impaired	JJ
cord-015021-pol2qm74	4196	13	cell	cell	NN
cord-015021-pol2qm74	4196	14	mediated	mediate	VBN
cord-015021-pol2qm74	4196	15	immune	immune	JJ
cord-015021-pol2qm74	4196	16	response	response	NN
cord-015021-pol2qm74	4196	17	(	(	-LRB-
cord-015021-pol2qm74	4196	18	CMI	CMI	NNP
cord-015021-pol2qm74	4196	19	)	)	-RRB-
cord-015021-pol2qm74	4196	20	resulting	result	VBG
cord-015021-pol2qm74	4196	21	from	from	IN
cord-015021-pol2qm74	4196	22	a	a	DT
cord-015021-pol2qm74	4196	23	disruption	disruption	NN
cord-015021-pol2qm74	4196	24	of	of	IN
cord-015021-pol2qm74	4196	25	intact	intact	JJ
cord-015021-pol2qm74	4196	26	M%/Tcell	M%/Tcell	NNP
cord-015021-pol2qm74	4196	27	interaction	interaction	NN
cord-015021-pol2qm74	4196	28	.	.	.
cord-015021-pol2qm74	4197	1	The	the	DT
cord-015021-pol2qm74	4197	2	current	current	JJ
cord-015021-pol2qm74	4197	3	study	study	NN
cord-015021-pol2qm74	4197	4	was	be	VBD
cord-015021-pol2qm74	4197	5	undertaken	undertake	VBN
cord-015021-pol2qm74	4197	6	to	to	TO
cord-015021-pol2qm74	4197	7	further	further	RB
cord-015021-pol2qm74	4197	8	elucidate	elucidate	VB
cord-015021-pol2qm74	4197	9	the	the	DT
cord-015021-pol2qm74	4197	10	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4197	11	of	of	IN
cord-015021-pol2qm74	4197	12	dysfimctional	dysfimctional	JJ
cord-015021-pol2qm74	4197	13	CMI	CMI	NNP
cord-015021-pol2qm74	4197	14	following	follow	VBG
cord-015021-pol2qm74	4197	15	major	major	JJ
cord-015021-pol2qm74	4197	16	burn	burn	NN
cord-015021-pol2qm74	4197	17	and	and	CC
cord-015021-pol2qm74	4197	18	mechanical	mechanical	JJ
cord-015021-pol2qm74	4197	19	trauma	trauma	NN
cord-015021-pol2qm74	4197	20	-via	-via	,
cord-015021-pol2qm74	4197	21	comparative	comparative	JJ
cord-015021-pol2qm74	4197	22	analysis	analysis	NN
cord-015021-pol2qm74	4197	23	of	of	IN
cord-015021-pol2qm74	4197	24	mRNA	mRNA	NNP
cord-015021-pol2qm74	4197	25	expression	expression	NN
cord-015021-pol2qm74	4197	26	and	and	CC
cord-015021-pol2qm74	4197	27	protein	protein	NN
cord-015021-pol2qm74	4197	28	release	release	NN
cord-015021-pol2qm74	4197	29	.	.	.
cord-015021-pol2qm74	4198	1	The	the	DT
cord-015021-pol2qm74	4198	2	major	major	JJ
cord-015021-pol2qm74	4198	3	regulatory	regulatory	JJ
cord-015021-pol2qm74	4198	4	levels	level	NNS
cord-015021-pol2qm74	4198	5	for	for	IN
cord-015021-pol2qm74	4198	6	different	different	JJ
cord-015021-pol2qm74	4198	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	4198	8	were	be	VBD
cord-015021-pol2qm74	4198	9	determined	determine	VBN
cord-015021-pol2qm74	4198	10	in	in	IN
cord-015021-pol2qm74	4198	11	mitogen	mitogen	NNP
cord-015021-pol2qm74	4198	12	,	,	,
cord-015021-pol2qm74	4198	13	respectively	respectively	RB
cord-015021-pol2qm74	4198	14	LPS	lp	NNS
cord-015021-pol2qm74	4198	15	stimulated	stimulate	VBD
cord-015021-pol2qm74	4198	16	peripheral	peripheral	JJ
cord-015021-pol2qm74	4198	17	blood	blood	NN
cord-015021-pol2qm74	4198	18	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	4198	19	cell	cell	NN
cord-015021-pol2qm74	4198	20	(	(	-LRB-
cord-015021-pol2qm74	4198	21	PBMC	PBMC	NNP
cord-015021-pol2qm74	4198	22	)	)	-RRB-
cord-015021-pol2qm74	4198	23	cultures	culture	NNS
cord-015021-pol2qm74	4198	24	of	of	IN
cord-015021-pol2qm74	4198	25	trauma	trauma	NN
cord-015021-pol2qm74	4198	26	patients	patient	NNS
cord-015021-pol2qm74	4198	27	on	on	IN
cord-015021-pol2qm74	4198	28	consecutive	consecutive	JJ
cord-015021-pol2qm74	4198	29	days	day	NNS
cord-015021-pol2qm74	4198	30	(	(	-LRB-
cord-015021-pol2qm74	4198	31	13	13	CD
cord-015021-pol2qm74	4198	32	)	)	-RRB-
cord-015021-pol2qm74	4198	33	t	t	NN
cord-015021-pol2qm74	4198	34	,	,	,
cord-015021-pol2qm74	4198	35	3	3	CD
cord-015021-pol2qm74	4198	36	,	,	,
cord-015021-pol2qm74	4198	37	5	5	CD
cord-015021-pol2qm74	4198	38	,	,	,
cord-015021-pol2qm74	4198	39	7	7	CD
cord-015021-pol2qm74	4198	40	and	and	CC
cord-015021-pol2qm74	4198	41	10	10	CD
cord-015021-pol2qm74	4198	42	post	post	NN
cord-015021-pol2qm74	4198	43	injury	injury	NN
cord-015021-pol2qm74	4198	44	.	.	.
cord-015021-pol2qm74	4199	1	We	-PRON-	PRP
cord-015021-pol2qm74	4199	2	analyzed	analyze	VBD
cord-015021-pol2qm74	4199	3	the	the	DT
cord-015021-pol2qm74	4199	4	cumulative	cumulative	JJ
cord-015021-pol2qm74	4199	5	data	datum	NNS
cord-015021-pol2qm74	4199	6	for	for	IN
cord-015021-pol2qm74	4199	7	Interleukin-1	Interleukin-1	NNP
cord-015021-pol2qm74	4199	8	beta	beta	NN
cord-015021-pol2qm74	4199	9	(	(	-LRB-
cord-015021-pol2qm74	4199	10	IL	IL	NNP
cord-015021-pol2qm74	4199	11	-	-	HYPH
cord-015021-pol2qm74	4199	12	I[3	I[3	NNP
cord-015021-pol2qm74	4199	13	)	)	-RRB-
cord-015021-pol2qm74	4199	14	,	,	.
cord-015021-pol2qm74	4200	1	IL-2	IL-2	NNP
cord-015021-pol2qm74	4200	2	,	,	,
cord-015021-pol2qm74	4200	3	IL-8	IL-8	NNP
cord-015021-pol2qm74	4200	4	as	as	RB
cord-015021-pol2qm74	4200	5	well	well	RB
cord-015021-pol2qm74	4200	6	as	as	IN
cord-015021-pol2qm74	4200	7	tumor	tumor	NN
cord-015021-pol2qm74	4200	8	necrosis	necrosis	NN
cord-015021-pol2qm74	4200	9	factor	factor	NN
cord-015021-pol2qm74	4200	10	alpha	alpha	NN
cord-015021-pol2qm74	4200	11	(	(	-LRB-
cord-015021-pol2qm74	4200	12	TNF-~	TNF-~	NNP
cord-015021-pol2qm74	4200	13	)	)	-RRB-
cord-015021-pol2qm74	4200	14	and	and	CC
cord-015021-pol2qm74	4200	15	saw	see	VBD
cord-015021-pol2qm74	4200	16	a	a	DT
cord-015021-pol2qm74	4200	17	considerable	considerable	JJ
cord-015021-pol2qm74	4200	18	impairment	impairment	NN
cord-015021-pol2qm74	4200	19	of	of	IN
cord-015021-pol2qm74	4200	20	the	the	DT
cord-015021-pol2qm74	4200	21	protein	protein	NN
cord-015021-pol2qm74	4200	22	release	release	NN
cord-015021-pol2qm74	4200	23	in	in	IN
cord-015021-pol2qm74	4200	24	the	the	DT
cord-015021-pol2qm74	4200	25	stimulated	stimulated	JJ
cord-015021-pol2qm74	4200	26	PBMC	PBMC	NNP
cord-015021-pol2qm74	4200	27	cultures	culture	NNS
cord-015021-pol2qm74	4200	28	until	until	IN
cord-015021-pol2qm74	4200	29	D5	D5	NNP
cord-015021-pol2qm74	4200	30	post	post	NN
cord-015021-pol2qm74	4200	31	-	-	JJ
cord-015021-pol2qm74	4200	32	trauma	trauma	NN
cord-015021-pol2qm74	4200	33	and	and	CC
cord-015021-pol2qm74	4200	34	recovery	recovery	NN
cord-015021-pol2qm74	4200	35	thereafter	thereafter	RB
cord-015021-pol2qm74	4200	36	.	.	.
cord-015021-pol2qm74	4201	1	*	*	NFP
cord-015021-pol2qm74	4201	2	p	p	XX
cord-015021-pol2qm74	4201	3	<	<	XX
cord-015021-pol2qm74	4201	4	0.05	0.05	CD
cord-015021-pol2qm74	4201	5	,	,	,
cord-015021-pol2qm74	4202	1	*	*	NFP
cord-015021-pol2qm74	4202	2	*	*	NFP
cord-015021-pol2qm74	4202	3	p	p	XX
cord-015021-pol2qm74	4202	4	<	<	XX
cord-015021-pol2qm74	4202	5	0.01	0.01	CD
cord-015021-pol2qm74	4202	6	vs	vs	IN
cord-015021-pol2qm74	4202	7	control	control	NN
cord-015021-pol2qm74	4202	8	Comparing	compare	VBG
cord-015021-pol2qm74	4202	9	the	the	DT
cord-015021-pol2qm74	4202	10	autoradiographies	autoradiography	NNS
cord-015021-pol2qm74	4202	11	of	of	IN
cord-015021-pol2qm74	4202	12	the	the	DT
cord-015021-pol2qm74	4202	13	specific	specific	JJ
cord-015021-pol2qm74	4202	14	cytokine	cytokine	NN
cord-015021-pol2qm74	4202	15	mRNA	mrna	NN
cord-015021-pol2qm74	4202	16	expression	expression	NN
cord-015021-pol2qm74	4202	17	with	with	IN
cord-015021-pol2qm74	4202	18	the	the	DT
cord-015021-pol2qm74	4202	19	protein	protein	NN
cord-015021-pol2qm74	4202	20	release	release	NN
cord-015021-pol2qm74	4202	21	in	in	IN
cord-015021-pol2qm74	4202	22	the	the	DT
cord-015021-pol2qm74	4202	23	supernatants	supernatant	NNS
cord-015021-pol2qm74	4202	24	,	,	,
cord-015021-pol2qm74	4202	25	we	-PRON-	PRP
cord-015021-pol2qm74	4202	26	saw	see	VBD
cord-015021-pol2qm74	4202	27	a	a	DT
cord-015021-pol2qm74	4202	28	good	good	JJ
cord-015021-pol2qm74	4202	29	correlation	correlation	NN
cord-015021-pol2qm74	4202	30	between	between	IN
cord-015021-pol2qm74	4202	31	mRNA	mRNA	NNP
cord-015021-pol2qm74	4202	32	signal	signal	JJ
cord-015021-pol2qm74	4202	33	intensity	intensity	NN
cord-015021-pol2qm74	4202	34	and	and	CC
cord-015021-pol2qm74	4202	35	protein	protein	NN
cord-015021-pol2qm74	4202	36	synthesis	synthesis	NN
cord-015021-pol2qm74	4202	37	for	for	IN
cord-015021-pol2qm74	4202	38	IL-8	IL-8	NNP
cord-015021-pol2qm74	4202	39	and	and	CC
cord-015021-pol2qm74	4202	40	11,-2	11,-2	CD
cord-015021-pol2qm74	4202	41	,	,	,
cord-015021-pol2qm74	4202	42	suggesting	suggest	VBG
cord-015021-pol2qm74	4202	43	that	that	IN
cord-015021-pol2qm74	4202	44	for	for	IN
cord-015021-pol2qm74	4202	45	these	these	DT
cord-015021-pol2qm74	4202	46	cytokines	cytokine	NNS
cord-015021-pol2qm74	4202	47	the	the	DT
cord-015021-pol2qm74	4202	48	main	main	JJ
cord-015021-pol2qm74	4202	49	regulatory	regulatory	JJ
cord-015021-pol2qm74	4202	50	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4202	51	are	be	VBP
cord-015021-pol2qm74	4202	52	located	locate	VBN
cord-015021-pol2qm74	4202	53	at	at	IN
cord-015021-pol2qm74	4202	54	the	the	DT
cord-015021-pol2qm74	4202	55	pre-/transcriptional	pre-/transcriptional	JJ
cord-015021-pol2qm74	4202	56	level	level	NN
cord-015021-pol2qm74	4202	57	.	.	.
cord-015021-pol2qm74	4203	1	For	for	IN
cord-015021-pol2qm74	4203	2	the	the	DT
cord-015021-pol2qm74	4203	3	other	other	JJ
cord-015021-pol2qm74	4203	4	cytokines	cytokine	NNS
cord-015021-pol2qm74	4203	5	investigated	investigate	VBD
cord-015021-pol2qm74	4203	6	one	one	CD
cord-015021-pol2qm74	4203	7	has	have	VBZ
cord-015021-pol2qm74	4203	8	to	to	TO
cord-015021-pol2qm74	4203	9	suppose	suppose	VB
cord-015021-pol2qm74	4203	10	posttranseriptional	posttranseriptional	JJ
cord-015021-pol2qm74	4203	11	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4203	12	.	.	.
cord-015021-pol2qm74	4204	1	The	the	DT
cord-015021-pol2qm74	4204	2	analysis	analysis	NN
cord-015021-pol2qm74	4204	3	of	of	IN
cord-015021-pol2qm74	4204	4	our	-PRON-	PRP$
cord-015021-pol2qm74	4204	5	data	datum	NNS
cord-015021-pol2qm74	4204	6	clearly	clearly	RB
cord-015021-pol2qm74	4204	7	indicates	indicate	VBZ
cord-015021-pol2qm74	4204	8	a	a	DT
cord-015021-pol2qm74	4204	9	severe	severe	JJ
cord-015021-pol2qm74	4204	10	impairment	impairment	NN
cord-015021-pol2qm74	4204	11	of	of	IN
cord-015021-pol2qm74	4204	12	forward	forward	JJ
cord-015021-pol2qm74	4204	13	regulatory	regulatory	JJ
cord-015021-pol2qm74	4204	14	immune	immune	JJ
cord-015021-pol2qm74	4204	15	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4204	16	following	follow	VBG
cord-015021-pol2qm74	4204	17	trauma	trauma	NN
cord-015021-pol2qm74	4204	18	.	.	.
cord-015021-pol2qm74	4205	1	Most	most	RBS
cord-015021-pol2qm74	4205	2	likely	likely	RB
cord-015021-pol2qm74	4205	3	the	the	DT
cord-015021-pol2qm74	4205	4	regulatory	regulatory	JJ
cord-015021-pol2qm74	4205	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4205	6	,	,	,
cord-015021-pol2qm74	4205	7	that	that	WDT
cord-015021-pol2qm74	4205	8	are	be	VBP
cord-015021-pol2qm74	4205	9	involved	involve	VBN
cord-015021-pol2qm74	4205	10	are	be	VBP
cord-015021-pol2qm74	4205	11	greatly	greatly	RB
cord-015021-pol2qm74	4205	12	different	different	JJ
cord-015021-pol2qm74	4205	13	among	among	IN
cord-015021-pol2qm74	4205	14	the	the	DT
cord-015021-pol2qm74	4205	15	cytokines	cytokine	NNS
cord-015021-pol2qm74	4205	16	investigated	investigate	VBN
cord-015021-pol2qm74	4205	17	.	.	.
cord-015021-pol2qm74	4206	1	It	-PRON-	PRP
cord-015021-pol2qm74	4206	2	may	may	MD
cord-015021-pol2qm74	4206	3	be	be	VB
cord-015021-pol2qm74	4206	4	concluded	conclude	VBN
cord-015021-pol2qm74	4206	5	,	,	,
cord-015021-pol2qm74	4206	6	that	that	DT
cord-015021-pol2qm74	4206	7	depressed	depressed	JJ
cord-015021-pol2qm74	4206	8	CMI	CMI	NNP
cord-015021-pol2qm74	4206	9	responses	response	NNS
cord-015021-pol2qm74	4206	10	post	post	NN
cord-015021-pol2qm74	4206	11	-	-	NN
cord-015021-pol2qm74	4206	12	trauma	trauma	NN
cord-015021-pol2qm74	4206	13	are	be	VBP
cord-015021-pol2qm74	4206	14	partly	partly	RB
cord-015021-pol2qm74	4206	15	due	due	JJ
cord-015021-pol2qm74	4206	16	to	to	IN
cord-015021-pol2qm74	4206	17	an	an	DT
cord-015021-pol2qm74	4206	18	impaired	impaired	JJ
cord-015021-pol2qm74	4206	19	pro	pro	JJ
cord-015021-pol2qm74	4206	20	-	-	JJ
cord-015021-pol2qm74	4206	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4206	22	cytokine	cytokine	NN
cord-015021-pol2qm74	4206	23	production	production	NN
cord-015021-pol2qm74	4206	24	.	.	.
cord-015021-pol2qm74	4207	1	The	the	DT
cord-015021-pol2qm74	4207	2	severity	severity	NN
cord-015021-pol2qm74	4207	3	of	of	IN
cord-015021-pol2qm74	4207	4	the	the	DT
cord-015021-pol2qm74	4207	5	injury	injury	NN
cord-015021-pol2qm74	4207	6	(	(	-LRB-
cord-015021-pol2qm74	4207	7	ISS	ISS	NNP
cord-015021-pol2qm74	4207	8	)	)	-RRB-
cord-015021-pol2qm74	4207	9	correlated	correlate	VBD
cord-015021-pol2qm74	4207	10	with	with	IN
cord-015021-pol2qm74	4207	11	the	the	DT
cord-015021-pol2qm74	4207	12	development	development	NN
cord-015021-pol2qm74	4207	13	at	at	IN
cord-015021-pol2qm74	4207	14	multiple	multiple	JJ
cord-015021-pol2qm74	4207	15	organ	organ	NN
cord-015021-pol2qm74	4207	16	failure	failure	NN
cord-015021-pol2qm74	4207	17	(	(	-LRB-
cord-015021-pol2qm74	4207	18	MOF	MOF	NNP
cord-015021-pol2qm74	4207	19	-	-	HYPH
cord-015021-pol2qm74	4207	20	score	score	NN
cord-015021-pol2qm74	4207	21	;	;	:
cord-015021-pol2qm74	4207	22	r=0.612	r=0.612	NNP
cord-015021-pol2qm74	4207	23	)	)	-RRB-
cord-015021-pol2qm74	4207	24	.	.	.
cord-015021-pol2qm74	4208	1	The	the	DT
cord-015021-pol2qm74	4208	2	levels	level	NNS
cord-015021-pol2qm74	4208	3	of	of	IN
cord-015021-pol2qm74	4208	4	mediators	mediator	NNS
cord-015021-pol2qm74	4208	5	and	and	CC
cord-015021-pol2qm74	4208	6	markers	marker	NNS
cord-015021-pol2qm74	4208	7	of	of	IN
cord-015021-pol2qm74	4208	8	the	the	DT
cord-015021-pol2qm74	4208	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4208	10	response	response	NN
cord-015021-pol2qm74	4208	11	were	be	VBD
cord-015021-pol2qm74	4208	12	generally	generally	RB
cord-015021-pol2qm74	4208	13	higher	high	JJR
cord-015021-pol2qm74	4208	14	in	in	IN
cord-015021-pol2qm74	4208	15	the	the	DT
cord-015021-pol2qm74	4208	16	more	more	RBR
cord-015021-pol2qm74	4208	17	severely	severely	RB
cord-015021-pol2qm74	4208	18	injured	injure	VBN
cord-015021-pol2qm74	4208	19	group	group	NN
cord-015021-pol2qm74	4208	20	(	(	-LRB-
cord-015021-pol2qm74	4208	21	ISS>30	ISS>30	NNP
cord-015021-pol2qm74	4208	22	,	,	,
cord-015021-pol2qm74	4208	23	n=16	n=16	NNP
cord-015021-pol2qm74	4208	24	)	)	-RRB-
cord-015021-pol2qm74	4208	25	.	.	.
cord-015021-pol2qm74	4209	1	I1	i1	NN
cord-015021-pol2qm74	4209	2	-	-	HYPH
cord-015021-pol2qm74	4209	3	6	6	CD
cord-015021-pol2qm74	4209	4	,	,	,
cord-015021-pol2qm74	4209	5	11	11	CD
cord-015021-pol2qm74	4209	6	-	-	SYM
cord-015021-pol2qm74	4209	7	8	8	CD
cord-015021-pol2qm74	4209	8	,	,	,
cord-015021-pol2qm74	4209	9	G	G	NNP
cord-015021-pol2qm74	4209	10	-	-	HYPH
cord-015021-pol2qm74	4209	11	CSF	CSF	NNP
cord-015021-pol2qm74	4209	12	,	,	,
cord-015021-pol2qm74	4209	13	FPA	FPA	NNP
cord-015021-pol2qm74	4209	14	,	,	,
cord-015021-pol2qm74	4209	15	and	and	CC
cord-015021-pol2qm74	4210	1	C3a	C3a	NNP
cord-015021-pol2qm74	4210	2	-levels	-level	NNS
cord-015021-pol2qm74	4210	3	differed	differ	VBD
cord-015021-pol2qm74	4210	4	significantly	significantly	RB
cord-015021-pol2qm74	4210	5	(	(	-LRB-
cord-015021-pol2qm74	4210	6	p<0.005	p<0.005	JJ
cord-015021-pol2qm74	4210	7	)	)	-RRB-
cord-015021-pol2qm74	4210	8	between	between	IN
cord-015021-pol2qm74	4210	9	the	the	DT
cord-015021-pol2qm74	4210	10	ISS	ISS	NNP
cord-015021-pol2qm74	4210	11	-	-	HYPH
cord-015021-pol2qm74	4210	12	groups	group	NNS
cord-015021-pol2qm74	4210	13	(	(	-LRB-
cord-015021-pol2qm74	4210	14	>	>	XX
cord-015021-pol2qm74	4210	15	-	-	HYPH
cord-015021-pol2qm74	4210	16	<	<	XX
cord-015021-pol2qm74	4210	17	ISS	ISS	NNP
cord-015021-pol2qm74	4210	18	30	30	CD
cord-015021-pol2qm74	4210	19	)	)	-RRB-
cord-015021-pol2qm74	4210	20	at	at	IN
cord-015021-pol2qm74	4210	21	the	the	DT
cord-015021-pol2qm74	4210	22	time	time	NN
cord-015021-pol2qm74	4210	23	of	of	IN
cord-015021-pol2qm74	4210	24	admission	admission	NN
cord-015021-pol2qm74	4210	25	,	,	,
cord-015021-pol2qm74	4210	26	whereas	whereas	IN
cord-015021-pol2qm74	4210	27	on	on	IN
cord-015021-pol2qm74	4210	28	day	day	NN
cord-015021-pol2qm74	4210	29	3	3	CD
cord-015021-pol2qm74	4210	30	TNFa	TNFa	NNS
cord-015021-pol2qm74	4210	31	,	,	,
cord-015021-pol2qm74	4210	32	C3a	C3a	NNP
cord-015021-pol2qm74	4210	33	,	,	,
cord-015021-pol2qm74	4210	34	11	11	CD
cord-015021-pol2qm74	4210	35	-	-	SYM
cord-015021-pol2qm74	4210	36	6	6	CD
cord-015021-pol2qm74	4210	37	,	,	,
cord-015021-pol2qm74	4210	38	and	and	CC
cord-015021-pol2qm74	4210	39	EalPI	EalPI	NNP
cord-015021-pol2qm74	4210	40	showed	show	VBD
cord-015021-pol2qm74	4210	41	significant	significant	JJ
cord-015021-pol2qm74	4210	42	differences	difference	NNS
cord-015021-pol2qm74	4210	43	.	.	.
cord-015021-pol2qm74	4211	1	Beyond	beyond	IN
cord-015021-pol2qm74	4211	2	the	the	DT
cord-015021-pol2qm74	4211	3	first	first	JJ
cord-015021-pol2qm74	4211	4	week	week	NN
cord-015021-pol2qm74	4211	5	,	,	,
cord-015021-pol2qm74	4211	6	major	major	JJ
cord-015021-pol2qm74	4211	7	differences	difference	NNS
cord-015021-pol2qm74	4211	8	were	be	VBD
cord-015021-pol2qm74	4211	9	restricted	restrict	VBN
cord-015021-pol2qm74	4211	10	to	to	IN
cord-015021-pol2qm74	4211	11	PGE	PGE	NNP
cord-015021-pol2qm74	4211	12	2	2	CD
cord-015021-pol2qm74	4211	13	and	and	CC
cord-015021-pol2qm74	4211	14	C3a	C3a	NNP
cord-015021-pol2qm74	4211	15	.	.	.
cord-015021-pol2qm74	4212	1	The	the	DT
cord-015021-pol2qm74	4212	2	formation	formation	NN
cord-015021-pol2qm74	4212	3	of	of	IN
cord-015021-pol2qm74	4212	4	two	two	CD
cord-015021-pol2qm74	4212	5	groups	group	NNS
cord-015021-pol2qm74	4212	6	with	with	IN
cord-015021-pol2qm74	4212	7	respect	respect	NN
cord-015021-pol2qm74	4212	8	to	to	IN
cord-015021-pol2qm74	4212	9	later	later	JJ
cord-015021-pol2qm74	4212	10	multiple	multiple	JJ
cord-015021-pol2qm74	4212	11	organ	organ	NN
cord-015021-pol2qm74	4212	12	failure	failure	NN
cord-015021-pol2qm74	4212	13	(	(	-LRB-
cord-015021-pol2qm74	4212	14	MOF	MOF	NNP
cord-015021-pol2qm74	4212	15	<	<	XX
cord-015021-pol2qm74	4212	16	3	3	CD
cord-015021-pol2qm74	4212	17	;	;	:
cord-015021-pol2qm74	4212	18	MOF	MOF	NNP
cord-015021-pol2qm74	4212	19	>	>	XX
cord-015021-pol2qm74	4213	1	2	2	CD
cord-015021-pol2qm74	4213	2	n=	n=	CD
cord-015021-pol2qm74	4213	3	14	14	CD
cord-015021-pol2qm74	4213	4	)	)	-RRB-
cord-015021-pol2qm74	4213	5	yielded	yield	VBD
cord-015021-pol2qm74	4213	6	similar	similar	JJ
cord-015021-pol2qm74	4213	7	results	result	NNS
cord-015021-pol2qm74	4213	8	.	.	.
cord-015021-pol2qm74	4214	1	Leukocyte	Leukocyte	NNP
cord-015021-pol2qm74	4214	2	-	-	HYPH
cord-015021-pol2qm74	4214	3	FACS	FACS	NNP
cord-015021-pol2qm74	4214	4	analysis	analysis	NN
cord-015021-pol2qm74	4214	5	revealed	reveal	VBD
cord-015021-pol2qm74	4214	6	significant	significant	JJ
cord-015021-pol2qm74	4214	7	differences	difference	NNS
cord-015021-pol2qm74	4214	8	mainly	mainly	RB
cord-015021-pol2qm74	4214	9	in	in	IN
cord-015021-pol2qm74	4214	10	the	the	DT
cord-015021-pol2qm74	4214	11	CD14	CD14	NNP
cord-015021-pol2qm74	4214	12	(	(	-LRB-
cord-015021-pol2qm74	4214	13	monocytes	monocyte	NNS
cord-015021-pol2qm74	4214	14	)	)	-RRB-
cord-015021-pol2qm74	4214	15	,	,	.
cord-015021-pol2qm74	4215	1	CD3	CD3	NNP
cord-015021-pol2qm74	4215	2	/	/	SYM
cord-015021-pol2qm74	4215	3	CD25	CD25	NNP
cord-015021-pol2qm74	4215	4	(	(	-LRB-
cord-015021-pol2qm74	4215	5	I1	i1	NN
cord-015021-pol2qm74	4215	6	-	-	HYPH
cord-015021-pol2qm74	4215	7	2R	2R	NNP
cord-015021-pol2qm74	4215	8	+	+	CC
cord-015021-pol2qm74	4215	9	T	t	NN
cord-015021-pol2qm74	4215	10	-	-	HYPH
cord-015021-pol2qm74	4215	11	cells	cell	NNS
cord-015021-pol2qm74	4215	12	)	)	-RRB-
cord-015021-pol2qm74	4215	13	,	,	,
cord-015021-pol2qm74	4215	14	and	and	CC
cord-015021-pol2qm74	4215	15	CD29	CD29	NNP
cord-015021-pol2qm74	4215	16	/	/	SYM
cord-015021-pol2qm74	4215	17	CD4	CD4	NNP
cord-015021-pol2qm74	4215	18	(	(	-LRB-
cord-015021-pol2qm74	4215	19	TH	TH	NNP
cord-015021-pol2qm74	4215	20	2calls	2calls	CD
cord-015021-pol2qm74	4215	21	)	)	-RRB-
cord-015021-pol2qm74	4215	22	populations	population	NNS
cord-015021-pol2qm74	4215	23	.	.	.
cord-015021-pol2qm74	4216	1	Summarizing	summarize	VBG
cord-015021-pol2qm74	4216	2	our	-PRON-	PRP$
cord-015021-pol2qm74	4216	3	findings	finding	NNS
cord-015021-pol2qm74	4216	4	we	-PRON-	PRP
cord-015021-pol2qm74	4216	5	were	be	VBD
cord-015021-pol2qm74	4216	6	able	able	JJ
cord-015021-pol2qm74	4216	7	to	to	TO
cord-015021-pol2qm74	4216	8	detect	detect	VB
cord-015021-pol2qm74	4216	9	some	some	DT
cord-015021-pol2qm74	4216	10	alterations	alteration	NNS
cord-015021-pol2qm74	4216	11	in	in	IN
cord-015021-pol2qm74	4216	12	the	the	DT
cord-015021-pol2qm74	4216	13	surface	surface	NN
cord-015021-pol2qm74	4216	14	antigens	antigen	NNS
cord-015021-pol2qm74	4216	15	of	of	IN
cord-015021-pol2qm74	4216	16	immunocompetent	immunocompetent	JJ
cord-015021-pol2qm74	4216	17	cells	cell	NNS
cord-015021-pol2qm74	4216	18	.	.	.
cord-015021-pol2qm74	4217	1	The	the	DT
cord-015021-pol2qm74	4217	2	inflammato	inflammato	NNP
cord-015021-pol2qm74	4217	3	D	D	NNP
cord-015021-pol2qm74	4217	4	response	response	NN
cord-015021-pol2qm74	4217	5	,	,	,
cord-015021-pol2qm74	4217	6	however	however	RB
cord-015021-pol2qm74	4217	7	,	,	,
cord-015021-pol2qm74	4217	8	seemed	seem	VBD
cord-015021-pol2qm74	4217	9	to	to	TO
cord-015021-pol2qm74	4217	10	be	be	VB
cord-015021-pol2qm74	4217	11	more	more	RBR
cord-015021-pol2qm74	4217	12	pronounced	pronounced	JJ
cord-015021-pol2qm74	4217	13	and	and	CC
cord-015021-pol2qm74	4217	14	correlates	correlate	VBZ
cord-015021-pol2qm74	4217	15	wi~	wi~	PRP
cord-015021-pol2qm74	4217	16	the	the	DT
cord-015021-pol2qm74	4217	17	further	further	JJ
cord-015021-pol2qm74	4217	18	clinical	clinical	JJ
cord-015021-pol2qm74	4217	19	course	course	NN
cord-015021-pol2qm74	4217	20	.	.	.
cord-015021-pol2qm74	4218	1	Using	use	VBG
cord-015021-pol2qm74	4218	2	an	an	DT
cord-015021-pol2qm74	4218	3	experimental	experimental	JJ
cord-015021-pol2qm74	4218	4	bum	bum	NN
cord-015021-pol2qm74	4218	5	model	model	NN
cord-015021-pol2qm74	4218	6	in	in	IN
cord-015021-pol2qm74	4218	7	rodents	rodent	NNS
cord-015021-pol2qm74	4218	8	,	,	,
cord-015021-pol2qm74	4218	9	we	-PRON-	PRP
cord-015021-pol2qm74	4218	10	have	have	VBP
cord-015021-pol2qm74	4218	11	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	4218	12	that	that	IN
cord-015021-pol2qm74	4218	13	administration	administration	NN
cord-015021-pol2qm74	4218	14	of	of	IN
cord-015021-pol2qm74	4218	15	a	a	DT
cord-015021-pol2qm74	4218	16	full	full	JJ
cord-015021-pol2qm74	4218	17	thickness	thickness	NN
cord-015021-pol2qm74	4218	18	,	,	,
cord-015021-pol2qm74	4218	19	scald	scald	NN
cord-015021-pol2qm74	4218	20	burn	burn	VB
cord-015021-pol2qm74	4218	21	involving	involve	VBG
cord-015021-pol2qm74	4218	22	20	20	CD
cord-015021-pol2qm74	4218	23	%	%	NN
cord-015021-pol2qm74	4218	24	or	or	CC
cord-015021-pol2qm74	4218	25	more	more	JJR
cord-015021-pol2qm74	4218	26	of	of	IN
cord-015021-pol2qm74	4218	27	the	the	DT
cord-015021-pol2qm74	4218	28	total	total	JJ
cord-015021-pol2qm74	4218	29	body	body	NN
cord-015021-pol2qm74	4218	30	surface	surface	NN
cord-015021-pol2qm74	4218	31	area	area	NN
cord-015021-pol2qm74	4218	32	(	(	-LRB-
cord-015021-pol2qm74	4218	33	TBSA	TBSA	NNP
cord-015021-pol2qm74	4218	34	)	)	-RRB-
cord-015021-pol2qm74	4218	35	elicits	elicit	VBZ
cord-015021-pol2qm74	4218	36	systemic	systemic	JJ
cord-015021-pol2qm74	4218	37	responses	response	NNS
cord-015021-pol2qm74	4218	38	which	which	WDT
cord-015021-pol2qm74	4218	39	are	be	VBP
cord-015021-pol2qm74	4218	40	characterized	characterize	VBN
cord-015021-pol2qm74	4218	41	by	by	IN
cord-015021-pol2qm74	4218	42	numerous	numerous	JJ
cord-015021-pol2qm74	4218	43	alterations	alteration	NNS
cord-015021-pol2qm74	4218	44	in	in	IN
cord-015021-pol2qm74	4218	45	T	T	NNP
cord-015021-pol2qm74	4218	46	-	-	HYPH
cord-015021-pol2qm74	4218	47	ceU	ceu	JJ
cord-015021-pol2qm74	4218	48	function	function	NN
cord-015021-pol2qm74	4218	49	(	(	-LRB-
cord-015021-pol2qm74	4218	50	i.e.	i.e.	FW
cord-015021-pol2qm74	4218	51	,	,	,
cord-015021-pol2qm74	4218	52	lymphokine	lymphokine	NN
cord-015021-pol2qm74	4218	53	production	production	NN
cord-015021-pol2qm74	4218	54	and	and	CC
cord-015021-pol2qm74	4218	55	contact	contact	NN
cord-015021-pol2qm74	4218	56	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	4218	57	(	(	-LRB-
cord-015021-pol2qm74	4218	58	CH	CH	NNP
cord-015021-pol2qm74	4218	59	)	)	-RRB-
cord-015021-pol2qm74	4218	60	responses	response	NNS
cord-015021-pol2qm74	4218	61	)	)	-RRB-
cord-015021-pol2qm74	4218	62	plus	plus	CC
cord-015021-pol2qm74	4218	63	an	an	DT
cord-015021-pol2qm74	4218	64	enhanced	enhance	VBN
cord-015021-pol2qm74	4218	65	susceptibility	susceptibility	NN
cord-015021-pol2qm74	4218	66	to	to	IN
cord-015021-pol2qm74	4218	67	bacterial	bacterial	JJ
cord-015021-pol2qm74	4218	68	infection	infection	NN
cord-015021-pol2qm74	4218	69	.	.	.
cord-015021-pol2qm74	4219	1	In	in	IN
cord-015021-pol2qm74	4219	2	the	the	DT
cord-015021-pol2qm74	4219	3	present	present	JJ
cord-015021-pol2qm74	4219	4	study	study	NN
cord-015021-pol2qm74	4219	5	we	-PRON-	PRP
cord-015021-pol2qm74	4219	6	questioned	question	VBD
cord-015021-pol2qm74	4219	7	whether	whether	IN
cord-015021-pol2qm74	4219	8	the	the	DT
cord-015021-pol2qm74	4219	9	apparent	apparent	JJ
cord-015021-pol2qm74	4219	10	systemic	systemic	JJ
cord-015021-pol2qm74	4219	11	effects	effect	NNS
cord-015021-pol2qm74	4219	12	mediated	mediate	VBN
cord-015021-pol2qm74	4219	13	by	by	IN
cord-015021-pol2qm74	4219	14	large	large	JJ
cord-015021-pol2qm74	4219	15	burns	burn	NNS
cord-015021-pol2qm74	4219	16	would	would	MD
cord-015021-pol2qm74	4219	17	be	be	VB
cord-015021-pol2qm74	4219	18	elicited	elicit	VBN
cord-015021-pol2qm74	4219	19	as	as	IN
cord-015021-pol2qm74	4219	20	site	site	NN
cord-015021-pol2qm74	4219	21	-	-	HYPH
cord-015021-pol2qm74	4219	22	specific	specific	JJ
cord-015021-pol2qm74	4219	23	alterations	alteration	NNS
cord-015021-pol2qm74	4219	24	in	in	IN
cord-015021-pol2qm74	4219	25	immune	immune	JJ
cord-015021-pol2qm74	4219	26	function	function	NN
cord-015021-pol2qm74	4219	27	following	follow	VBG
cord-015021-pol2qm74	4219	28	administration	administration	NN
cord-015021-pol2qm74	4219	29	of	of	IN
cord-015021-pol2qm74	4219	30	small	small	JJ
cord-015021-pol2qm74	4219	31	area	area	NN
cord-015021-pol2qm74	4219	32	burn	burn	VBP
cord-015021-pol2qm74	4219	33	trauma	trauma	NN
cord-015021-pol2qm74	4219	34	(	(	-LRB-
cord-015021-pol2qm74	4219	35	5	5	CD
cord-015021-pol2qm74	4219	36	%	%	NN
cord-015021-pol2qm74	4219	37	TBSA	TBSA	NNP
cord-015021-pol2qm74	4219	38	)	)	-RRB-
cord-015021-pol2qm74	4219	39	.	.	.
cord-015021-pol2qm74	4220	1	Following	follow	VBG
cord-015021-pol2qm74	4220	2	a	a	DT
cord-015021-pol2qm74	4220	3	20	20	CD
cord-015021-pol2qm74	4220	4	%	%	NN
cord-015021-pol2qm74	4220	5	TBSA	TBSA	NNP
cord-015021-pol2qm74	4220	6	burn	burn	NN
cord-015021-pol2qm74	4220	7	,	,	,
cord-015021-pol2qm74	4220	8	CH	CH	NNP
cord-015021-pol2qm74	4220	9	responses	response	NNS
cord-015021-pol2qm74	4220	10	to	to	TO
cord-015021-pol2qm74	4220	11	contact	contact	VB
cord-015021-pol2qm74	4220	12	sensitizing	sensitize	VBG
cord-015021-pol2qm74	4220	13	antigens	antigen	NNS
cord-015021-pol2qm74	4220	14	were	be	VBD
cord-015021-pol2qm74	4220	15	found	find	VBN
cord-015021-pol2qm74	4220	16	to	to	TO
cord-015021-pol2qm74	4220	17	be	be	VB
cord-015021-pol2qm74	4220	18	altered	alter	VBN
cord-015021-pol2qm74	4220	19	.	.	.
cord-015021-pol2qm74	4221	1	The	the	DT
cord-015021-pol2qm74	4221	2	depression	depression	NN
cord-015021-pol2qm74	4221	3	in	in	IN
cord-015021-pol2qm74	4221	4	CH	CH	NNP
cord-015021-pol2qm74	4221	5	responses	response	NNS
cord-015021-pol2qm74	4221	6	could	could	MD
cord-015021-pol2qm74	4221	7	be	be	VB
cord-015021-pol2qm74	4221	8	induced	induce	VBN
cord-015021-pol2qm74	4221	9	independent	independent	JJ
cord-015021-pol2qm74	4221	10	of	of	IN
cord-015021-pol2qm74	4221	11	the	the	DT
cord-015021-pol2qm74	4221	12	site	site	NN
cord-015021-pol2qm74	4221	13	used	use	VBN
cord-015021-pol2qm74	4221	14	for	for	IN
cord-015021-pol2qm74	4221	15	topical	topical	JJ
cord-015021-pol2qm74	4221	16	skin	skin	NN
cord-015021-pol2qm74	4221	17	sensitization	sensitization	NN
cord-015021-pol2qm74	4221	18	.	.	.
cord-015021-pol2qm74	4222	1	Following	follow	VBG
cord-015021-pol2qm74	4222	2	a	a	DT
cord-015021-pol2qm74	4222	3	5	5	CD
cord-015021-pol2qm74	4222	4	%	%	NN
cord-015021-pol2qm74	4222	5	TBSA	TBSA	NNP
cord-015021-pol2qm74	4222	6	thermal	thermal	JJ
cord-015021-pol2qm74	4222	7	injury	injury	NN
cord-015021-pol2qm74	4222	8	,	,	,
cord-015021-pol2qm74	4222	9	development	development	NN
cord-015021-pol2qm74	4222	10	of	of	IN
cord-015021-pol2qm74	4222	11	CH	CH	NNP
cord-015021-pol2qm74	4222	12	responses	response	NNS
cord-015021-pol2qm74	4222	13	were	be	VBD
cord-015021-pol2qm74	4222	14	affected	affect	VBN
cord-015021-pol2qm74	4222	15	in	in	IN
cord-015021-pol2qm74	4222	16	a	a	DT
cord-015021-pol2qm74	4222	17	site	site	NN
cord-015021-pol2qm74	4222	18	-	-	HYPH
cord-015021-pol2qm74	4222	19	specific	specific	JJ
cord-015021-pol2qm74	4222	20	manner	manner	NN
cord-015021-pol2qm74	4222	21	.	.	.
cord-015021-pol2qm74	4223	1	Immunization	immunization	NN
cord-015021-pol2qm74	4223	2	of	of	IN
cord-015021-pol2qm74	4223	3	5	5	CD
cord-015021-pol2qm74	4223	4	%	%	NN
cord-015021-pol2qm74	4223	5	TBSA	TBSA	NNP
cord-015021-pol2qm74	4223	6	thermally	thermally	RB
cord-015021-pol2qm74	4223	7	injured	injure	VBD
cord-015021-pol2qm74	4223	8	mice	mouse	NNS
cord-015021-pol2qm74	4223	9	in	in	IN
cord-015021-pol2qm74	4223	10	a	a	DT
cord-015021-pol2qm74	4223	11	site	site	NN
cord-015021-pol2qm74	4223	12	near	near	IN
cord-015021-pol2qm74	4223	13	the	the	DT
cord-015021-pol2qm74	4223	14	position	position	NN
cord-015021-pol2qm74	4223	15	of	of	IN
cord-015021-pol2qm74	4223	16	the	the	DT
cord-015021-pol2qm74	4223	17	burn	burn	NN
cord-015021-pol2qm74	4223	18	resulted	result	VBD
cord-015021-pol2qm74	4223	19	in	in	IN
cord-015021-pol2qm74	4223	20	depressed	depressed	JJ
cord-015021-pol2qm74	4223	21	responsiveness	responsiveness	NN
cord-015021-pol2qm74	4223	22	,	,	,
cord-015021-pol2qm74	4223	23	whereas	whereas	IN
cord-015021-pol2qm74	4223	24	immunization	immunization	NN
cord-015021-pol2qm74	4223	25	through	through	IN
cord-015021-pol2qm74	4223	26	a	a	DT
cord-015021-pol2qm74	4223	27	contralateral	contralateral	JJ
cord-015021-pol2qm74	4223	28	site	site	NN
cord-015021-pol2qm74	4223	29	resulted	result	VBD
cord-015021-pol2qm74	4223	30	in	in	IN
cord-015021-pol2qm74	4223	31	responses	response	NNS
cord-015021-pol2qm74	4223	32	that	that	WDT
cord-015021-pol2qm74	4223	33	displayed	display	VBD
cord-015021-pol2qm74	4223	34	both	both	CC
cord-015021-pol2qm74	4223	35	the	the	DT
cord-015021-pol2qm74	4223	36	intensity	intensity	NN
cord-015021-pol2qm74	4223	37	and	and	CC
cord-015021-pol2qm74	4223	38	kinetics	kinetic	NNS
cord-015021-pol2qm74	4223	39	of	of	IN
cord-015021-pol2qm74	4223	40	a	a	DT
cord-015021-pol2qm74	4223	41	CH	CH	NNP
cord-015021-pol2qm74	4223	42	response	response	NN
cord-015021-pol2qm74	4223	43	equivalent	equivalent	JJ
cord-015021-pol2qm74	4223	44	to	to	IN
cord-015021-pol2qm74	4223	45	sham	sham	NN
cord-015021-pol2qm74	4223	46	-	-	HYPH
cord-015021-pol2qm74	4223	47	bumed	bum	VBN
cord-015021-pol2qm74	4223	48	mice	mouse	NNS
cord-015021-pol2qm74	4223	49	.	.	.
cord-015021-pol2qm74	4224	1	Similar	similar	JJ
cord-015021-pol2qm74	4224	2	systemic	systemic	JJ
cord-015021-pol2qm74	4224	3	and	and	CC
cord-015021-pol2qm74	4224	4	site	site	NN
cord-015021-pol2qm74	4224	5	-	-	HYPH
cord-015021-pol2qm74	4224	6	limited	limit	VBN
cord-015021-pol2qm74	4224	7	changes	change	NNS
cord-015021-pol2qm74	4224	8	in	in	IN
cord-015021-pol2qm74	4224	9	lymphokine	lymphokine	NN
cord-015021-pol2qm74	4224	10	production	production	NN
cord-015021-pol2qm74	4224	11	were	be	VBD
cord-015021-pol2qm74	4224	12	observed	observe	VBN
cord-015021-pol2qm74	4224	13	with	with	IN
cord-015021-pol2qm74	4224	14	20	20	CD
cord-015021-pol2qm74	4224	15	%	%	NN
cord-015021-pol2qm74	4224	16	and	and	CC
cord-015021-pol2qm74	4224	17	5	5	CD
cord-015021-pol2qm74	4224	18	%	%	NN
cord-015021-pol2qm74	4224	19	TBSA	TBSA	NNP
cord-015021-pol2qm74	4224	20	thermal	thermal	JJ
cord-015021-pol2qm74	4224	21	injuries	injury	NNS
cord-015021-pol2qm74	4224	22	,	,	,
cord-015021-pol2qm74	4224	23	respectively	respectively	RB
cord-015021-pol2qm74	4224	24	.	.	.
cord-015021-pol2qm74	4225	1	A	a	DT
cord-015021-pol2qm74	4225	2	20	20	CD
cord-015021-pol2qm74	4225	3	%	%	NN
cord-015021-pol2qm74	4225	4	TBSA	TBSA	NNP
cord-015021-pol2qm74	4225	5	injury	injury	NN
cord-015021-pol2qm74	4225	6	affected	affect	VBD
cord-015021-pol2qm74	4225	7	the	the	DT
cord-015021-pol2qm74	4225	8	lymphokine	lymphokine	NN
cord-015021-pol2qm74	4225	9	producing	produce	VBG
cord-015021-pol2qm74	4225	10	potential	potential	NN
cord-015021-pol2qm74	4225	11	of	of	IN
cord-015021-pol2qm74	4225	12	all	all	DT
cord-015021-pol2qm74	4225	13	cells	cell	NNS
cord-015021-pol2qm74	4225	14	regardless	regardless	RB
cord-015021-pol2qm74	4225	15	of	of	IN
cord-015021-pol2qm74	4225	16	which	which	WDT
cord-015021-pol2qm74	4225	17	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	4225	18	tissue	tissue	VBP
cord-015021-pol2qm74	4225	19	the	the	DT
cord-015021-pol2qm74	4225	20	cells	cell	NNS
cord-015021-pol2qm74	4225	21	were	be	VBD
cord-015021-pol2qm74	4225	22	isolated	isolate	VBN
cord-015021-pol2qm74	4225	23	from	from	IN
cord-015021-pol2qm74	4225	24	.	.	.
cord-015021-pol2qm74	4226	1	The	the	DT
cord-015021-pol2qm74	4226	2	effect	effect	NN
cord-015021-pol2qm74	4226	3	of	of	IN
cord-015021-pol2qm74	4226	4	a	a	DT
cord-015021-pol2qm74	4226	5	5	5	CD
cord-015021-pol2qm74	4226	6	%	%	NN
cord-015021-pol2qm74	4226	7	TBSA	TBSA	NNP
cord-015021-pol2qm74	4226	8	burn	burn	NN
cord-015021-pol2qm74	4226	9	was	be	VBD
cord-015021-pol2qm74	4226	10	significant	significant	JJ
cord-015021-pol2qm74	4226	11	but	but	CC
cord-015021-pol2qm74	4226	12	site	site	NN
cord-015021-pol2qm74	4226	13	-	-	HYPH
cord-015021-pol2qm74	4226	14	specific	specific	JJ
cord-015021-pol2qm74	4226	15	.	.	.
cord-015021-pol2qm74	4227	1	Thus	thus	RB
cord-015021-pol2qm74	4227	2	,	,	,
cord-015021-pol2qm74	4227	3	ceils	ceil	NNS
cord-015021-pol2qm74	4227	4	from	from	IN
cord-015021-pol2qm74	4227	5	lymph	lymph	NN
cord-015021-pol2qm74	4227	6	nodes	node	NNS
cord-015021-pol2qm74	4227	7	receiving	receive	VBG
cord-015021-pol2qm74	4227	8	drainage	drainage	NN
cord-015021-pol2qm74	4227	9	from	from	IN
cord-015021-pol2qm74	4227	10	thermally	thermally	RB
cord-015021-pol2qm74	4227	11	injured	injure	VBN
cord-015021-pol2qm74	4227	12	tissue	tissue	NN
cord-015021-pol2qm74	4227	13	were	be	VBD
cord-015021-pol2qm74	4227	14	specifically	specifically	RB
cord-015021-pol2qm74	4227	15	affected	affect	VBN
cord-015021-pol2qm74	4227	16	,	,	,
cord-015021-pol2qm74	4227	17	whereas	whereas	IN
cord-015021-pol2qm74	4227	18	lymphokine	lymphokine	NN
cord-015021-pol2qm74	4227	19	production	production	NN
cord-015021-pol2qm74	4227	20	by	by	IN
cord-015021-pol2qm74	4227	21	cells	cell	NNS
cord-015021-pol2qm74	4227	22	from	from	IN
cord-015021-pol2qm74	4227	23	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	4227	24	organs	organ	NNS
cord-015021-pol2qm74	4227	25	receiving	receive	VBG
cord-015021-pol2qm74	4227	26	drainage	drainage	NN
cord-015021-pol2qm74	4227	27	from	from	IN
cord-015021-pol2qm74	4227	28	unaffected	unaffected	JJ
cord-015021-pol2qm74	4227	29	skin	skin	NN
cord-015021-pol2qm74	4227	30	was	be	VBD
cord-015021-pol2qm74	4227	31	normal	normal	JJ
cord-015021-pol2qm74	4227	32	.	.	.
cord-015021-pol2qm74	4228	1	It	-PRON-	PRP
cord-015021-pol2qm74	4228	2	was	be	VBD
cord-015021-pol2qm74	4228	3	concluded	conclude	VBN
cord-015021-pol2qm74	4228	4	that	that	IN
cord-015021-pol2qm74	4228	5	modulation	modulation	NN
cord-015021-pol2qm74	4228	6	of	of	IN
cord-015021-pol2qm74	4228	7	lymphokine	lymphokine	NN
cord-015021-pol2qm74	4228	8	production	production	NN
cord-015021-pol2qm74	4228	9	and	and	CC
cord-015021-pol2qm74	4228	10	cellular	cellular	JJ
cord-015021-pol2qm74	4228	11	immune	immune	JJ
cord-015021-pol2qm74	4228	12	responses	response	NNS
cord-015021-pol2qm74	4228	13	may	may	MD
cord-015021-pol2qm74	4228	14	be	be	VB
cord-015021-pol2qm74	4228	15	a	a	DT
cord-015021-pol2qm74	4228	16	normal	normal	JJ
cord-015021-pol2qm74	4228	17	consequence	consequence	NN
cord-015021-pol2qm74	4228	18	of	of	IN
cord-015021-pol2qm74	4228	19	burntrauma	burntrauma	NN
cord-015021-pol2qm74	4228	20	regardless	regardless	RB
cord-015021-pol2qm74	4228	21	of	of	IN
cord-015021-pol2qm74	4228	22	the	the	DT
cord-015021-pol2qm74	4228	23	size	size	NN
cord-015021-pol2qm74	4228	24	of	of	IN
cord-015021-pol2qm74	4228	25	the	the	DT
cord-015021-pol2qm74	4228	26	burn	burn	NN
cord-015021-pol2qm74	4228	27	.	.	.
cord-015021-pol2qm74	4229	1	Changes	change	NNS
cord-015021-pol2qm74	4229	2	in	in	IN
cord-015021-pol2qm74	4229	3	immune	immune	JJ
cord-015021-pol2qm74	4229	4	competence	competence	NN
cord-015021-pol2qm74	4229	5	can	can	MD
cord-015021-pol2qm74	4229	6	be	be	VB
cord-015021-pol2qm74	4229	7	mediated	mediate	VBN
cord-015021-pol2qm74	4229	8	either	either	CC
cord-015021-pol2qm74	4229	9	regionally	regionally	RB
cord-015021-pol2qm74	4229	10	or	or	CC
cord-015021-pol2qm74	4229	11	systemically	systemically	RB
cord-015021-pol2qm74	4229	12	in	in	IN
cord-015021-pol2qm74	4229	13	direct	direct	JJ
cord-015021-pol2qm74	4229	14	proportion	proportion	NN
cord-015021-pol2qm74	4229	15	to	to	IN
cord-015021-pol2qm74	4229	16	the	the	DT
cord-015021-pol2qm74	4229	17	area	area	NN
cord-015021-pol2qm74	4229	18	of	of	IN
cord-015021-pol2qm74	4229	19	skin	skin	NN
cord-015021-pol2qm74	4229	20	exposed	expose	VBN
cord-015021-pol2qm74	4229	21	to	to	IN
cord-015021-pol2qm74	4229	22	the	the	DT
cord-015021-pol2qm74	4229	23	burn	burn	NN
cord-015021-pol2qm74	4229	24	injury	injury	NN
cord-015021-pol2qm74	4229	25	.	.	.
cord-015021-pol2qm74	4230	1	This	this	DT
cord-015021-pol2qm74	4230	2	work	work	NN
cord-015021-pol2qm74	4230	3	is	be	VBZ
cord-015021-pol2qm74	4230	4	supported	support	VBN
cord-015021-pol2qm74	4230	5	by	by	IN
cord-015021-pol2qm74	4230	6	PHS	PHS	NNP
cord-015021-pol2qm74	4230	7	grant	grant	VBP
cord-015021-pol2qm74	4230	8	GM46899	GM46899	NNP
cord-015021-pol2qm74	4230	9	and	and	CC
cord-015021-pol2qm74	4230	10	the	the	DT
cord-015021-pol2qm74	4230	11	Office	Office	NNP
cord-015021-pol2qm74	4230	12	of	of	IN
cord-015021-pol2qm74	4230	13	Navy	Navy	NNP
cord-015021-pol2qm74	4230	14	Research	Research	NNP
cord-015021-pol2qm74	4230	15	N00014	N00014	NNP
cord-015021-pol2qm74	4230	16	-	-	HYPH
cord-015021-pol2qm74	4230	17	92-J-1612	92-J-1612	NNP
cord-015021-pol2qm74	4230	18	.	.	.
cord-015021-pol2qm74	4231	1	Division	division	NN
cord-015021-pol2qm74	4231	2	of	of	IN
cord-015021-pol2qm74	4231	3	Cell	Cell	NNP
cord-015021-pol2qm74	4231	4	Biology	Biology	NNP
cord-015021-pol2qm74	4231	5	and	and	CC
cord-015021-pol2qm74	4231	6	Immunology	Immunology	NNP
cord-015021-pol2qm74	4231	7	,	,	,
cord-015021-pol2qm74	4231	8	Department	Department	NNP
cord-015021-pol2qm74	4231	9	of	of	IN
cord-015021-pol2qm74	4231	10	Pathology	Pathology	NNP
cord-015021-pol2qm74	4231	11	,	,	,
cord-015021-pol2qm74	4231	12	University	University	NNP
cord-015021-pol2qm74	4231	13	of	of	IN
cord-015021-pol2qm74	4231	14	Utah	Utah	NNP
cord-015021-pol2qm74	4231	15	School	School	NNP
cord-015021-pol2qm74	4231	16	of	of	IN
cord-015021-pol2qm74	4231	17	Medicine	Medicine	NNP
cord-015021-pol2qm74	4231	18	,	,	,
cord-015021-pol2qm74	4231	19	Salt	Salt	NNP
cord-015021-pol2qm74	4231	20	Lake	Lake	NNP
cord-015021-pol2qm74	4231	21	City	City	NNP
cord-015021-pol2qm74	4231	22	,	,	,
cord-015021-pol2qm74	4231	23	UT	UT	NNP
cord-015021-pol2qm74	4231	24	84132	84132	CD
cord-015021-pol2qm74	4231	25	.	.	.
cord-015021-pol2qm74	4232	1	Post	post	JJ
cord-015021-pol2qm74	4232	2	spleneetomy	spleneetomy	NN
cord-015021-pol2qm74	4232	3	septic	septic	JJ
cord-015021-pol2qm74	4232	4	sequelae	sequela	NNS
cord-015021-pol2qm74	4232	5	may	may	MD
cord-015021-pol2qm74	4232	6	Be	be	VB
cord-015021-pol2qm74	4232	7	fatal	fatal	JJ
cord-015021-pol2qm74	4232	8	,	,	,
cord-015021-pol2qm74	4232	9	but	but	CC
cord-015021-pol2qm74	4232	10	the	the	DT
cord-015021-pol2qm74	4232	11	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4232	12	remain	remain	VBP
cord-015021-pol2qm74	4232	13	unclear	unclear	JJ
cord-015021-pol2qm74	4232	14	.	.	.
cord-015021-pol2qm74	4233	1	The	the	DT
cord-015021-pol2qm74	4233	2	objectives	objective	NNS
cord-015021-pol2qm74	4233	3	ef	ef	NNP
cord-015021-pol2qm74	4233	4	this	this	DT
cord-015021-pol2qm74	4233	5	study	study	NN
cord-015021-pol2qm74	4233	6	were	be	VBD
cord-015021-pol2qm74	4233	7	to	to	TO
cord-015021-pol2qm74	4233	8	assess	assess	VB
cord-015021-pol2qm74	4233	9	the	the	DT
cord-015021-pol2qm74	4233	10	mortality	mortality	NN
cord-015021-pol2qm74	4233	11	from	from	IN
cord-015021-pol2qm74	4233	12	concomitant	concomitant	JJ
cord-015021-pol2qm74	4233	13	splen-'etomy	splen-'etomy	NN
cord-015021-pol2qm74	4233	14	and	and	CC
cord-015021-pol2qm74	4233	15	]	]	-RRB-
cord-015021-pol2qm74	4234	1	~eritoneal	~eritoneal	JJ
cord-015021-pol2qm74	4234	2	bacterial	bacterial	JJ
cord-015021-pol2qm74	4234	3	challenge	challenge	NN
cord-015021-pol2qm74	4234	4	and	and	CC
cord-015021-pol2qm74	4234	5	to	to	TO
cord-015021-pol2qm74	4234	6	elucidate	elucidate	VB
cord-015021-pol2qm74	4234	7	the	the	DT
cord-015021-pol2qm74	4234	8	local	local	JJ
cord-015021-pol2qm74	4234	9	cetkdar	cetkdar	NN
cord-015021-pol2qm74	4234	10	responses	response	NNS
cord-015021-pol2qm74	4234	11	.	.	.
cord-015021-pol2qm74	4235	1	50	50	CD
cord-015021-pol2qm74	4235	2	CD-1	CD-1	NNP
cord-015021-pol2qm74	4235	3	mice	mouse	NNS
cord-015021-pol2qm74	4235	4	were	be	VBD
cord-015021-pol2qm74	4235	5	randomised	randomised	JJ
cord-015021-pol2qm74	4235	6	to	to	TO
cord-015021-pol2qm74	4235	7	receive	receive	VB
cord-015021-pol2qm74	4235	8	laparotomy	laparotomy	NN
cord-015021-pol2qm74	4235	9	and	and	CC
cord-015021-pol2qm74	4235	10	sham	sham	NN
cord-015021-pol2qm74	4235	11	splenectomy	splenectomy	NN
cord-015021-pol2qm74	4235	12	(	(	-LRB-
cord-015021-pol2qm74	4235	13	L	L	NNP
cord-015021-pol2qm74	4235	14	)	)	-RRB-
cord-015021-pol2qm74	4235	15	or	or	CC
cord-015021-pol2qm74	4235	16	splenectomy	splenectomy	NN
cord-015021-pol2qm74	4235	17	(	(	-LRB-
cord-015021-pol2qm74	4235	18	S	s	NN
cord-015021-pol2qm74	4235	19	)	)	-RRB-
cord-015021-pol2qm74	4235	20	with	with	IN
cord-015021-pol2qm74	4235	21	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	4235	22	ca'-cal	ca'-cal	JJ
cord-015021-pol2qm74	4235	23	ligation	ligation	NN
cord-015021-pol2qm74	4235	24	and	and	CC
cord-015021-pol2qm74	4235	25	"	"	''
cord-015021-pol2qm74	4235	26	)	)	-RRB-
cord-015021-pol2qm74	4235	27	:	:	:
cord-015021-pol2qm74	4235	28	mcture	mcture	NNP
cord-015021-pol2qm74	4235	29	and	and	CC
cord-015021-pol2qm74	4235	30	the	the	DT
cord-015021-pol2qm74	4235	31	survival	survival	NN
cord-015021-pol2qm74	4235	32	patterns	pattern	NNS
cord-015021-pol2qm74	4235	33	assessed	assess	VBN
cord-015021-pol2qm74	4235	34	.	.	.
cord-015021-pol2qm74	4236	1	Subsequently	subsequently	RB
cord-015021-pol2qm74	4236	2	,	,	,
cord-015021-pol2qm74	4236	3	150	150	CD
cord-015021-pol2qm74	4236	4	CD-1	CD-1	NNP
cord-015021-pol2qm74	4236	5	mice	mouse	NNS
cord-015021-pol2qm74	4236	6	were	be	VBD
cord-015021-pol2qm74	4236	7	randomised	randomised	JJ
cord-015021-pol2qm74	4236	8	into	into	IN
cord-015021-pol2qm74	4236	9	control	control	NN
cord-015021-pol2qm74	4236	10	(	(	-LRB-
cord-015021-pol2qm74	4236	11	C	C	NNP
cord-015021-pol2qm74	4236	12	)	)	-RRB-
cord-015021-pol2qm74	4236	13	,	,	,
cord-015021-pol2qm74	4236	14	L	L	NNP
cord-015021-pol2qm74	4236	15	or	or	CC
cord-015021-pol2qm74	4236	16	S	S	NNP
cord-015021-pol2qm74	4236	17	groups	group	NNS
cord-015021-pol2qm74	4236	18	and	and	CC
cord-015021-pol2qm74	4236	19	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4236	20	cells	cell	NNS
cord-015021-pol2qm74	4236	21	studied	study	VBD
cord-015021-pol2qm74	4236	22	at	at	IN
cord-015021-pol2qm74	4236	23	24	24	CD
cord-015021-pol2qm74	4236	24	hours	hour	NNS
cord-015021-pol2qm74	4236	25	for	for	IN
cord-015021-pol2qm74	4236	26	bacterial	bacterial	JJ
cord-015021-pol2qm74	4236	27	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	4236	28	and	and	CC
cord-015021-pol2qm74	4236	29	killi:~g	killi:~g	NN
cord-015021-pol2qm74	4236	30	,	,	,
cord-015021-pol2qm74	4236	31	superoxide	superoxide	NN
cord-015021-pol2qm74	4236	32	(	(	-LRB-
cord-015021-pol2qm74	4236	33	02-	02-	NNP
cord-015021-pol2qm74	4236	34	)	)	-RRB-
cord-015021-pol2qm74	4236	35	and	and	CC
cord-015021-pol2qm74	4236	36	tumour	tumour	NN
cord-015021-pol2qm74	4236	37	necrosis	necrosis	NN
cord-015021-pol2qm74	4236	38	factor	factor	NN
cord-015021-pol2qm74	4236	39	(	(	-LRB-
cord-015021-pol2qm74	4236	40	TNF	TNF	NNP
cord-015021-pol2qm74	4236	41	)	)	-RRB-
cord-015021-pol2qm74	4236	42	production	production	NN
cord-015021-pol2qm74	4236	43	and	and	CC
cord-015021-pol2qm74	4236	44	macrophage	macrophage	NN
cord-015021-pol2qm74	4236	45	activation	activation	NN
cord-015021-pol2qm74	4236	46	vsing	vse	VBG
cord-015021-pol2qm74	4236	47	MAC	MAC	NNP
cord-015021-pol2qm74	4236	48	-	-	HYPH
cord-015021-pol2qm74	4236	49	I(CD-11b	I(CD-11b	NNPS
cord-015021-pol2qm74	4236	50	)	)	-RRB-
cord-015021-pol2qm74	4236	51	receptor	receptor	NN
cord-015021-pol2qm74	4236	52	in~.ensity	in~.ensity	NN
cord-015021-pol2qm74	4236	53	expressed	express	VBD
cord-015021-pol2qm74	4236	54	es	es	NNP
cord-015021-pol2qm74	4236	55	mean	mean	NNP
cord-015021-pol2qm74	4236	56	channel	channel	NNP
cord-015021-pol2qm74	4236	57	of	of	IN
cord-015021-pol2qm74	4236	58	fluorescence	fluorescence	NN
cord-015021-pol2qm74	4236	59	(	(	-LRB-
cord-015021-pol2qm74	4236	60	MCF	MCF	NNP
cord-015021-pol2qm74	4236	61	)	)	-RRB-
cord-015021-pol2qm74	4236	62	.	.	.
cord-015021-pol2qm74	4237	1	These	these	DT
cord-015021-pol2qm74	4237	2	resides	reside	NNS
cord-015021-pol2qm74	4237	3	indicate	indicate	VBP
cord-015021-pol2qm74	4237	4	that	that	IN
cord-015021-pol2qm74	4237	5	SF!enectomy	SF!enectomy	NNP
cord-015021-pol2qm74	4237	6	predisposes	predispose	VBZ
cord-015021-pol2qm74	4237	7	to	to	TO
cord-015021-pol2qm74	4237	8	nrortal	nrortal	VB
cord-015021-pol2qm74	4237	9	~	~	NFP
cord-015021-pol2qm74	4237	10	ty	ty	UH
cord-015021-pol2qm74	4237	11	from	from	IN
cord-015021-pol2qm74	4237	12	bacterial	bacterial	JJ
cord-015021-pol2qm74	4237	13	sepsis	sepsis	NN
cord-015021-pol2qm74	4237	14	ia	ia	NNP
cord-015021-pol2qm74	4237	15	the	the	DT
cord-015021-pol2qm74	4237	16	early	early	JJ
cord-015021-pol2qm74	4237	17	pos~	pos~	CD
cord-015021-pol2qm74	4237	18	operative	operative	JJ
cord-015021-pol2qm74	4237	19	period	period	NN
cord-015021-pol2qm74	4237	20	compared	compare	VBN
cord-015021-pol2qm74	4237	21	to	to	IN
cord-015021-pol2qm74	4237	22	sham	sham	NN
cord-015021-pol2qm74	4237	23	operated	operate	VBN
cord-015021-pol2qm74	4237	24	animals	animal	NNS
cord-015021-pol2qm74	4237	25	.	.	.
cord-015021-pol2qm74	4238	1	Failure	failure	NN
cord-015021-pol2qm74	4239	1	~f	~f	NNP
cord-015021-pol2qm74	4239	2	P'.acrophages	p'.acrophage	VBZ
cord-015021-pol2qm74	4239	3	to	to	TO
cord-015021-pol2qm74	4239	4	kill	kill	VB
cord-015021-pol2qm74	4239	5	bacteria	bacteria	NNS
cord-015021-pol2qm74	4239	6	in	in	IN
cord-015021-pol2qm74	4239	7	the	the	DT
cord-015021-pol2qm74	4239	8	splenectomv	splenectomv	NNP
cord-015021-pol2qm74	4239	9	group	group	NNP
cord-015021-pol2qm74	4239	10	'	'	''
cord-015021-pol2qm74	4240	1	~:cured	~:cure	VBN
cord-015021-pol2qm74	4240	2	in	in	IN
cord-015021-pol2qm74	4240	3	t?~e	t?~e	JJ
cord-015021-pol2qm74	4240	4	absence	absence	NN
cord-015021-pol2qm74	4240	5	of	of	IN
cord-015021-pol2qm74	4240	6	impairment	impairment	NN
cord-015021-pol2qm74	4240	7	of	of	IN
cord-015021-pol2qm74	4240	8	oxygen	oxygen	NN
cord-015021-pol2qm74	4240	9	freeradical	freeradical	JJ
cord-015021-pol2qm74	4240	10	or	or	CC
cord-015021-pol2qm74	4240	11	TNF	TNF	NNP
cord-015021-pol2qm74	4240	12	pred:~ctien	pred:~ctien	NNP
cord-015021-pol2qm74	4240	13	.	.	.
cord-015021-pol2qm74	4241	1	The	the	DT
cord-015021-pol2qm74	4241	2	macrovh~	macrovh~	NNP
cord-015021-pol2qm74	4242	1	ge	ge	NNP
cord-015021-pol2qm74	4242	2	ac!ivotion	ac!ivotion	NNP
cord-015021-pol2qm74	4242	3	marker	marker	NN
cord-015021-pol2qm74	4242	4	MAC-1	MAC-1	NNP
cord-015021-pol2qm74	4242	5	was	be	VBD
cord-015021-pol2qm74	4242	6	significantly	significantly	RB
cord-015021-pol2qm74	4242	7	reduced	reduce	VBN
cord-015021-pol2qm74	4242	8	in	in	IN
cord-015021-pol2qm74	4242	9	both	both	DT
cord-015021-pol2qm74	4242	10	L	L	NNP
cord-015021-pol2qm74	4242	11	and	and	CC
cord-015021-pol2qm74	4242	12	S	S	NNP
cord-015021-pol2qm74	4242	13	groups	group	NNS
cord-015021-pol2qm74	4242	14	and	and	CC
cord-015021-pol2qm74	4242	15	impaired	impaired	JJ
cord-015021-pol2qm74	4242	16	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	4242	17	of	of	IN
cord-015021-pol2qm74	4242	18	bacteria	bacteria	NNS
cord-015021-pol2qm74	4242	19	oceured	oceure	VBN
cord-015021-pol2qm74	4242	20	in	in	IN
cord-015021-pol2qm74	4242	21	both	both	DT
cord-015021-pol2qm74	4242	22	operative	operative	JJ
cord-015021-pol2qm74	4242	23	groups	group	NNS
cord-015021-pol2qm74	4242	24	compared	compare	VBN
cord-015021-pol2qm74	4242	25	to	to	IN
cord-015021-pol2qm74	4242	26	controls	control	NNS
cord-015021-pol2qm74	4242	27	.	.	.
cord-015021-pol2qm74	4243	1	Laparotomy	laparotomy	NN
cord-015021-pol2qm74	4243	2	a!one	a!one	NN
cord-015021-pol2qm74	4243	3	reduces	reduce	VBZ
cord-015021-pol2qm74	4243	4	macrophage	macrophage	NN
cord-015021-pol2qm74	4243	5	activity	activity	NN
cord-015021-pol2qm74	4243	6	in	in	IN
cord-015021-pol2qm74	4243	7	terms	term	NNS
cord-015021-pol2qm74	4243	8	of	of	IN
cord-015021-pol2qm74	4243	9	surface	surface	NN
cord-015021-pol2qm74	4243	10	re	re	NNP
cord-015021-pol2qm74	4243	11	:	:	:
cord-015021-pol2qm74	4243	12	eptor	eptor	NNP
cord-015021-pol2qm74	4243	13	MAC-1	MAC-1	NNP
cord-015021-pol2qm74	4243	14	expression	expression	NN
cord-015021-pol2qm74	4243	15	and	and	CC
cord-015021-pol2qm74	4243	16	!	!	.
cord-015021-pol2qm74	4244	1	ingestive	ingestive	JJ
cord-015021-pol2qm74	4244	2	capacity	capacity	NN
cord-015021-pol2qm74	4244	3	.	.	.
cord-015021-pol2qm74	4245	1	Splenectomy	Splenectomy	NNP
cord-015021-pol2qm74	4245	2	however	however	RB
cord-015021-pol2qm74	4245	3	s	s	VBZ
cord-015021-pol2qm74	4245	4	~	~	CD
cord-015021-pol2qm74	4245	5	gnificantiy	gnificantiy	NNP
cord-015021-pol2qm74	4246	1	~mpairs	~mpairs	NNP
cord-015021-pol2qm74	4246	2	r	r	NN
cord-015021-pol2qm74	4246	3	-	-	HYPH
cord-015021-pol2qm74	4246	4	acrophage	acrophage	NN
cord-015021-pol2qm74	4246	5	-	-	HYPH
cord-015021-pol2qm74	4246	6	wediated	wediate	VBN
cord-015021-pol2qm74	4246	7	l~,acterial	l~,acterial	CD
cord-015021-pol2qm74	4246	8	killing	killing	NN
cord-015021-pol2qm74	4246	9	and	and	CC
cord-015021-pol2qm74	4246	10	this	this	DT
cord-015021-pol2qm74	4246	11	qefect	qefect	NN
cord-015021-pol2qm74	4247	1	rTtav	rTtav	NNP
cord-015021-pol2qm74	4247	2	co	co	NN
cord-015021-pol2qm74	4247	3	~	~	CD
cord-015021-pol2qm74	4247	4	tribut~	tribut~	NNP
cord-015021-pol2qm74	4247	5	sig~	sig~	CD
cord-015021-pol2qm74	4248	1	ifJcav'ly	ifjcav'ly	XX
cord-015021-pol2qm74	4249	1	to	to	IN
cord-015021-pol2qm74	4249	2	th-~	th-~	NNP
cord-015021-pol2qm74	4249	3	dissemination	dissemination	NN
cord-015021-pol2qm74	4249	4	of	of	IN
cord-015021-pol2qm74	4249	5	local	local	JJ
cord-015021-pol2qm74	4249	6	infection	infection	NN
cord-015021-pol2qm74	4249	7	and	and	CC
cord-015021-pol2qm74	4249	8	to	to	IN
cord-015021-pol2qm74	4249	9	n':ortalit	n':ortalit	CD
cord-015021-pol2qm74	4249	10	)	)	-RRB-
cord-015021-pol2qm74	4249	11	.	.	.
cord-015021-pol2qm74	4250	1	Depts	dept	NNS
cord-015021-pol2qm74	4250	2	of	of	IN
cord-015021-pol2qm74	4250	3	Haem~	Haem~	NNP
cord-015021-pol2qm74	4250	4	tology	tology	NNP
cord-015021-pol2qm74	4250	5	&	&	CC
cord-015021-pol2qm74	4250	6	Surgery	Surgery	NNP
cord-015021-pol2qm74	4250	7	,	,	,
cord-015021-pol2qm74	4250	8	Beaumont	Beaumont	NNP
cord-015021-pol2qm74	4250	9	Hosoital	Hosoital	NNP
cord-015021-pol2qm74	4250	10	,	,	,
cord-015021-pol2qm74	4250	11	Dub!in	Dub!in	''
cord-015021-pol2qm74	4250	12	9,Eire	9,eire	ADD
cord-015021-pol2qm74	4250	13	.	.	.
cord-015021-pol2qm74	4251	1	INTRODUCTION	introduction	NN
cord-015021-pol2qm74	4251	2	:	:	:
cord-015021-pol2qm74	4252	1	Loss	loss	NN
cord-015021-pol2qm74	4252	2	of	of	IN
cord-015021-pol2qm74	4252	3	cell	cell	NN
cord-015021-pol2qm74	4252	4	membrane	membrane	NN
cord-015021-pol2qm74	4252	5	integrity	integrity	NN
cord-015021-pol2qm74	4252	6	appears	appear	VBZ
cord-015021-pol2qm74	4252	7	to	to	TO
cord-015021-pol2qm74	4252	8	be	be	VB
cord-015021-pol2qm74	4252	9	a	a	DT
cord-015021-pol2qm74	4252	10	common	common	JJ
cord-015021-pol2qm74	4252	11	pathway	pathway	NN
cord-015021-pol2qm74	4252	12	of	of	IN
cord-015021-pol2qm74	4252	13	injury	injury	NN
cord-015021-pol2qm74	4252	14	to	to	IN
cord-015021-pol2qm74	4252	15	tissues	tissue	NNS
cord-015021-pol2qm74	4252	16	subjected	subject	VBN
cord-015021-pol2qm74	4252	17	to	to	IN
cord-015021-pol2qm74	4252	18	high	high	JJ
cord-015021-pol2qm74	4252	19	-	-	HYPH
cord-015021-pol2qm74	4252	20	voltage	voltage	NN
cord-015021-pol2qm74	4252	21	electrical	electrical	JJ
cord-015021-pol2qm74	4252	22	shock	shock	NN
cord-015021-pol2qm74	4252	23	.	.	.
cord-015021-pol2qm74	4253	1	The	the	DT
cord-015021-pol2qm74	4253	2	cell	cell	NN
cord-015021-pol2qm74	4253	3	membrane	membrane	NN
cord-015021-pol2qm74	4253	4	is	be	VBZ
cord-015021-pol2qm74	4253	5	the	the	DT
cord-015021-pol2qm74	4253	6	most	most	JJS
cord-015021-pol2qm74	4253	7	heat	heat	NN
cord-015021-pol2qm74	4253	8	labile	labile	JJ
cord-015021-pol2qm74	4253	9	structure	structure	NN
cord-015021-pol2qm74	4253	10	in	in	IN
cord-015021-pol2qm74	4253	11	the	the	DT
cord-015021-pol2qm74	4253	12	cell	cell	NN
cord-015021-pol2qm74	4253	13	,	,	,
cord-015021-pol2qm74	4253	14	and	and	CC
cord-015021-pol2qm74	4253	15	is	be	VBZ
cord-015021-pol2qm74	4253	16	also	also	RB
cord-015021-pol2qm74	4253	17	the	the	DT
cord-015021-pol2qm74	4253	18	most	most	RBS
cord-015021-pol2qm74	4253	19	vulnerable	vulnerable	JJ
cord-015021-pol2qm74	4253	20	to	to	IN
cord-015021-pol2qm74	4253	21	externally	externally	RB
cord-015021-pol2qm74	4253	22	-	-	HYPH
cord-015021-pol2qm74	4253	23	imposed	impose	VBN
cord-015021-pol2qm74	4253	24	electrical	electrical	JJ
cord-015021-pol2qm74	4253	25	forces	force	NNS
cord-015021-pol2qm74	4253	26	.	.	.
cord-015021-pol2qm74	4254	1	Skeletal	skeletal	JJ
cord-015021-pol2qm74	4254	2	muscle	muscle	NN
cord-015021-pol2qm74	4254	3	and	and	CC
cord-015021-pol2qm74	4254	4	nerve	nerve	NN
cord-015021-pol2qm74	4254	5	cells	cell	NNS
cord-015021-pol2qm74	4254	6	are	be	VBP
cord-015021-pol2qm74	4254	7	particularly	particularly	RB
cord-015021-pol2qm74	4254	8	susceptible	susceptible	JJ
cord-015021-pol2qm74	4254	9	to	to	IN
cord-015021-pol2qm74	4254	10	electroporation	electroporation	NN
cord-015021-pol2qm74	4254	11	by	by	IN
cord-015021-pol2qm74	4254	12	clinically	clinically	RB
cord-015021-pol2qm74	4254	13	relevant	relevant	JJ
cord-015021-pol2qm74	4254	14	electric	electric	JJ
cord-015021-pol2qm74	4254	15	fields	field	NNS
cord-015021-pol2qm74	4254	16	.	.	.
cord-015021-pol2qm74	4255	1	Restoration	restoration	NN
cord-015021-pol2qm74	4255	2	of	of	IN
cord-015021-pol2qm74	4255	3	membrane	membrane	NN
cord-015021-pol2qm74	4255	4	integrity	integrity	NN
cord-015021-pol2qm74	4255	5	is	be	VBZ
cord-015021-pol2qm74	4255	6	essential	essential	JJ
cord-015021-pol2qm74	4255	7	for	for	IN
cord-015021-pol2qm74	4255	8	cell	cell	NN
cord-015021-pol2qm74	4255	9	survival	survival	NN
cord-015021-pol2qm74	4255	10	in	in	IN
cord-015021-pol2qm74	4255	11	victims	victim	NNS
cord-015021-pol2qm74	4255	12	of	of	IN
cord-015021-pol2qm74	4255	13	electrical	electrical	JJ
cord-015021-pol2qm74	4255	14	shock	shock	NN
cord-015021-pol2qm74	4255	15	.	.	.
cord-015021-pol2qm74	4256	1	We	-PRON-	PRP
cord-015021-pol2qm74	4256	2	have	have	VBP
cord-015021-pol2qm74	4256	3	studied	study	VBN
cord-015021-pol2qm74	4256	4	the	the	DT
cord-015021-pol2qm74	4256	5	effect	effect	NN
cord-015021-pol2qm74	4256	6	of	of	IN
cord-015021-pol2qm74	4256	7	non	non	JJ
cord-015021-pol2qm74	4256	8	-	-	JJ
cord-015021-pol2qm74	4256	9	ionic	ionic	JJ
cord-015021-pol2qm74	4256	10	triblock	triblock	NN
cord-015021-pol2qm74	4256	11	copolymers	copolymer	NNS
cord-015021-pol2qm74	4256	12	(	(	-LRB-
cord-015021-pol2qm74	4256	13	poloxamer	poloxamer	NNP
cord-015021-pol2qm74	4256	14	class	class	NNP
cord-015021-pol2qm74	4256	15	)	)	-RRB-
cord-015021-pol2qm74	4256	16	on	on	IN
cord-015021-pol2qm74	4256	17	the	the	DT
cord-015021-pol2qm74	4256	18	transport	transport	NN
cord-015021-pol2qm74	4256	19	properties	property	NNS
cord-015021-pol2qm74	4256	20	of	of	IN
cord-015021-pol2qm74	4256	21	isolated	isolate	VBN
cord-015021-pol2qm74	4256	22	rat	rat	NN
cord-015021-pol2qm74	4256	23	skeletal	skeletal	JJ
cord-015021-pol2qm74	4256	24	muscle	muscle	NN
cord-015021-pol2qm74	4256	25	cells	cell	NNS
cord-015021-pol2qm74	4256	26	following	follow	VBG
cord-015021-pol2qm74	4256	27	electroporation	electroporation	NN
cord-015021-pol2qm74	4256	28	-	-	HYPH
cord-015021-pol2qm74	4256	29	induced	induce	VBN
cord-015021-pol2qm74	4256	30	membrane	membrane	NN
cord-015021-pol2qm74	4256	31	disruption	disruption	NN
cord-015021-pol2qm74	4256	32	.	.	.
cord-015021-pol2qm74	4257	1	1	1	LS
cord-015021-pol2qm74	4257	2	-	-	SYM
cord-015021-pol2qm74	4257	3	3	3	CD
cord-015021-pol2qm74	4257	4	mm	mm	NN
cord-015021-pol2qm74	4257	5	long	long	JJ
cord-015021-pol2qm74	4257	6	adult	adult	NN
cord-015021-pol2qm74	4257	7	skeletal	skeletal	JJ
cord-015021-pol2qm74	4257	8	muscle	muscle	NN
cord-015021-pol2qm74	4257	9	fibers	fiber	NNS
cord-015021-pol2qm74	4257	10	were	be	VBD
cord-015021-pol2qm74	4257	11	isolated	isolate	VBN
cord-015021-pol2qm74	4257	12	by	by	IN
cord-015021-pol2qm74	4257	13	enzymatic	enzymatic	JJ
cord-015021-pol2qm74	4257	14	digestion	digestion	NN
cord-015021-pol2qm74	4257	15	from	from	IN
cord-015021-pol2qm74	4257	16	the	the	DT
cord-015021-pol2qm74	4257	17	rat	rat	NN
cord-015021-pol2qm74	4257	18	Flexor	Flexor	NNP
cord-015021-pol2qm74	4257	19	Digitorium	Digitorium	NNP
cord-015021-pol2qm74	4257	20	Brevus	Brevus	NNP
cord-015021-pol2qm74	4257	21	and	and	CC
cord-015021-pol2qm74	4257	22	maintained	maintain	VBN
cord-015021-pol2qm74	4257	23	under	under	IN
cord-015021-pol2qm74	4257	24	standard	standard	JJ
cord-015021-pol2qm74	4257	25	culture	culture	NN
cord-015021-pol2qm74	4257	26	conditions	condition	NNS
cord-015021-pol2qm74	4257	27	.	.	.
cord-015021-pol2qm74	4258	1	They	-PRON-	PRP
cord-015021-pol2qm74	4258	2	were	be	VBD
cord-015021-pol2qm74	4258	3	loaded	load	VBN
cord-015021-pol2qm74	4258	4	with	with	IN
cord-015021-pol2qm74	4258	5	the	the	DT
cord-015021-pol2qm74	4258	6	Calcein	Calcein	NNP
cord-015021-pol2qm74	4258	7	-	-	HYPH
cord-015021-pol2qm74	4258	8	AM	am	NN
cord-015021-pol2qm74	4258	9	dye	dye	NN
cord-015021-pol2qm74	4258	10	and	and	CC
cord-015021-pol2qm74	4258	11	placed	place	VBN
cord-015021-pol2qm74	4258	12	in	in	IN
cord-015021-pol2qm74	4258	13	a	a	DT
cord-015021-pol2qm74	4258	14	37,C	37,c	CD
cord-015021-pol2qm74	4258	15	chamber	chamber	NN
cord-015021-pol2qm74	4258	16	for	for	IN
cord-015021-pol2qm74	4258	17	recording	record	VBG
cord-015021-pol2qm74	4258	18	by	by	IN
cord-015021-pol2qm74	4258	19	real	real	JJ
cord-015021-pol2qm74	4258	20	-	-	HYPH
cord-015021-pol2qm74	4258	21	time	time	NN
cord-015021-pol2qm74	4258	22	video	video	NN
cord-015021-pol2qm74	4258	23	confocal	confocal	JJ
cord-015021-pol2qm74	4258	24	microscopy	microscopy	NNS
cord-015021-pol2qm74	4258	25	.	.	.
cord-015021-pol2qm74	4259	1	The	the	DT
cord-015021-pol2qm74	4259	2	cells	cell	NNS
cord-015021-pol2qm74	4259	3	were	be	VBD
cord-015021-pol2qm74	4259	4	subjected	subject	VBN
cord-015021-pol2qm74	4259	5	to	to	IN
cord-015021-pol2qm74	4259	6	4	4	CD
cord-015021-pol2qm74	4259	7	mSec	mSec	NNP
cord-015021-pol2qm74	4259	8	,	,	,
cord-015021-pol2qm74	4259	9	150	150	CD
cord-015021-pol2qm74	4259	10	V	v	NN
cord-015021-pol2qm74	4259	11	/	/	SYM
cord-015021-pol2qm74	4259	12	era	era	NN
cord-015021-pol2qm74	4259	13	,	,	,
cord-015021-pol2qm74	4259	14	1	1	CD
cord-015021-pol2qm74	4259	15	A	a	DT
cord-015021-pol2qm74	4259	16	field	field	NN
cord-015021-pol2qm74	4259	17	pulses	pulse	VBZ
cord-015021-pol2qm74	4259	18	with	with	IN
cord-015021-pol2qm74	4259	19	a	a	DT
cord-015021-pol2qm74	4259	20	low	low	JJ
cord-015021-pol2qm74	4259	21	duty	duty	NN
cord-015021-pol2qm74	4259	22	cycle	cycle	NN
cord-015021-pol2qm74	4259	23	to	to	TO
cord-015021-pol2qm74	4259	24	allow	allow	VB
cord-015021-pol2qm74	4259	25	thermal	thermal	JJ
cord-015021-pol2qm74	4259	26	relaxation	relaxation	NN
cord-015021-pol2qm74	4259	27	.	.	.
cord-015021-pol2qm74	4260	1	Peak	peak	NN
cord-015021-pol2qm74	4260	2	temperature	temperature	NN
cord-015021-pol2qm74	4260	3	rise	rise	NN
cord-015021-pol2qm74	4260	4	was	be	VBD
cord-015021-pol2qm74	4260	5	0,2.C.	0,2.c.	CD
cord-015021-pol2qm74	4261	1	The	the	DT
cord-015021-pol2qm74	4261	2	uye	uye	NN
cord-015021-pol2qm74	4261	3	content	content	NN
cord-015021-pol2qm74	4261	4	of	of	IN
cord-015021-pol2qm74	4261	5	the	the	DT
cord-015021-pol2qm74	4261	6	cell	cell	NN
cord-015021-pol2qm74	4261	7	was	be	VBD
cord-015021-pol2qm74	4261	8	monitored	monitor	VBN
cord-015021-pol2qm74	4261	9	in	in	IN
cord-015021-pol2qm74	4261	10	real	real	JJ
cord-015021-pol2qm74	4261	11	time	time	NN
cord-015021-pol2qm74	4261	12	.	.	.
cord-015021-pol2qm74	4262	1	Experiments	experiment	NNS
cord-015021-pol2qm74	4262	2	were	be	VBD
cord-015021-pol2qm74	4262	3	carried	carry	VBN
cord-015021-pol2qm74	4262	4	out	out	RP
cord-015021-pol2qm74	4262	5	in	in	IN
cord-015021-pol2qm74	4262	6	calcium	calcium	NN
cord-015021-pol2qm74	4262	7	-	-	HYPH
cord-015021-pol2qm74	4262	8	free	free	JJ
cord-015021-pol2qm74	4262	9	phosphate	phosphate	NN
cord-015021-pol2qm74	4262	10	buffered	buffer	VBN
cord-015021-pol2qm74	4262	11	saline	saline	NN
cord-015021-pol2qm74	4262	12	,	,	,
cord-015021-pol2qm74	4262	13	with	with	IN
cord-015021-pol2qm74	4262	14	1	1	CD
cord-015021-pol2qm74	4262	15	mM	mm	CD
cord-015021-pol2qm74	4262	16	Mg%	Mg%	NNP
cord-015021-pol2qm74	4262	17	.	.	.
cord-015021-pol2qm74	4263	1	Experiments	experiment	NNS
cord-015021-pol2qm74	4263	2	were	be	VBD
cord-015021-pol2qm74	4263	3	repeated	repeat	VBN
cord-015021-pol2qm74	4263	4	with	with	IN
cord-015021-pol2qm74	4263	5	4	4	CD
cord-015021-pol2qm74	4263	6	mM	mm	CD
cord-015021-pol2qm74	4263	7	neutral	neutral	JJ
cord-015021-pol2qm74	4263	8	dextran	dextran	NN
cord-015021-pol2qm74	4263	9	(	(	-LRB-
cord-015021-pol2qm74	4263	10	The	the	DT
cord-015021-pol2qm74	4263	11	aim	aim	NN
cord-015021-pol2qm74	4263	12	of	of	IN
cord-015021-pol2qm74	4263	13	the	the	DT
cord-015021-pol2qm74	4263	14	present	present	JJ
cord-015021-pol2qm74	4263	15	paper	paper	NN
cord-015021-pol2qm74	4263	16	is	be	VBZ
cord-015021-pol2qm74	4263	17	to	to	TO
cord-015021-pol2qm74	4263	18	ascertain	ascertain	VB
cord-015021-pol2qm74	4263	19	if	if	IN
cord-015021-pol2qm74	4263	20	thuracotomy	thuracotomy	NN
cord-015021-pol2qm74	4263	21	induces	induce	VBZ
cord-015021-pol2qm74	4263	22	a	a	DT
cord-015021-pol2qm74	4263	23	different	different	JJ
cord-015021-pol2qm74	4263	24	pattern	pattern	NN
cord-015021-pol2qm74	4263	25	of	of	IN
cord-015021-pol2qm74	4263	26	variations	variation	NNS
cord-015021-pol2qm74	4263	27	of	of	IN
cord-015021-pol2qm74	4263	28	cytokines	cytokine	NNS
cord-015021-pol2qm74	4263	29	,	,	,
cord-015021-pol2qm74	4263	30	immunocompetent	immunocompetent	JJ
cord-015021-pol2qm74	4263	31	cells	cell	NNS
cord-015021-pol2qm74	4263	32	and	and	CC
cord-015021-pol2qm74	4263	33	antibodies	antibody	NNS
cord-015021-pol2qm74	4263	34	from	from	IN
cord-015021-pol2qm74	4263	35	laparotomy	laparotomy	NN
cord-015021-pol2qm74	4263	36	in	in	IN
cord-015021-pol2qm74	4263	37	the	the	DT
cord-015021-pol2qm74	4263	38	early	early	JJ
cord-015021-pol2qm74	4263	39	postoperative	postoperative	JJ
cord-015021-pol2qm74	4263	40	period	period	NN
cord-015021-pol2qm74	4263	41	.	.	.
cord-015021-pol2qm74	4264	1	60	60	CD
cord-015021-pol2qm74	4264	2	patients	patient	NNS
cord-015021-pol2qm74	4264	3	(	(	-LRB-
cord-015021-pol2qm74	4264	4	34	34	CD
cord-015021-pol2qm74	4264	5	males	male	NNS
cord-015021-pol2qm74	4264	6	26	26	CD
cord-015021-pol2qm74	4264	7	females	female	NNS
cord-015021-pol2qm74	4264	8	,	,	,
cord-015021-pol2qm74	4264	9	mean	mean	VB
cord-015021-pol2qm74	4264	10	age	age	NN
cord-015021-pol2qm74	4264	11	:	:	:
cord-015021-pol2qm74	4264	12	59.5_+5	59.5_+5	CD
cord-015021-pol2qm74	4264	13	)	)	-RRB-
cord-015021-pol2qm74	4264	14	30	30	CD
cord-015021-pol2qm74	4264	15	with	with	IN
cord-015021-pol2qm74	4264	16	gallstone	gallstone	NN
cord-015021-pol2qm74	4264	17	disease	disease	NN
cord-015021-pol2qm74	4264	18	and	and	CC
cord-015021-pol2qm74	4264	19	30	30	CD
cord-015021-pol2qm74	4264	20	with	with	IN
cord-015021-pol2qm74	4264	21	non	non	JJ
cord-015021-pol2qm74	4264	22	neoplastic	neoplastic	JJ
cord-015021-pol2qm74	4264	23	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4264	24	disease	disease	NN
cord-015021-pol2qm74	4264	25	were	be	VBD
cord-015021-pol2qm74	4264	26	studied	study	VBN
cord-015021-pol2qm74	4264	27	.	.	.
cord-015021-pol2qm74	4265	1	None	none	NN
cord-015021-pol2qm74	4265	2	of	of	IN
cord-015021-pol2qm74	4265	3	these	these	DT
cord-015021-pol2qm74	4265	4	patients	patient	NNS
cord-015021-pol2qm74	4265	5	received	receive	VBD
cord-015021-pol2qm74	4265	6	blood	blood	NN
cord-015021-pol2qm74	4265	7	transfusion	transfusion	NN
cord-015021-pol2qm74	4265	8	,	,	,
cord-015021-pol2qm74	4265	9	biological	biological	JJ
cord-015021-pol2qm74	4265	10	response	response	NN
cord-015021-pol2qm74	4265	11	modifiers	modifier	NNS
cord-015021-pol2qm74	4265	12	,	,	,
cord-015021-pol2qm74	4265	13	radiotherapy	radiotherapy	NN
cord-015021-pol2qm74	4265	14	or	or	CC
cord-015021-pol2qm74	4265	15	surgery	surgery	NN
cord-015021-pol2qm74	4265	16	for	for	IN
cord-015021-pol2qm74	4265	17	at	at	RB
cord-015021-pol2qm74	4265	18	least	least	RBS
cord-015021-pol2qm74	4265	19	6	6	CD
cord-015021-pol2qm74	4265	20	months	month	NNS
cord-015021-pol2qm74	4265	21	before	before	IN
cord-015021-pol2qm74	4265	22	being	be	VBG
cord-015021-pol2qm74	4265	23	included	include	VBN
cord-015021-pol2qm74	4265	24	in	in	IN
cord-015021-pol2qm74	4265	25	our	-PRON-	PRP$
cord-015021-pol2qm74	4265	26	study	study	NN
cord-015021-pol2qm74	4265	27	.	.	.
cord-015021-pol2qm74	4266	1	Anaesthetic	anaesthetic	JJ
cord-015021-pol2qm74	4266	2	procedures	procedure	NNS
cord-015021-pol2qm74	4266	3	were	be	VBD
cord-015021-pol2qm74	4266	4	similar	similar	JJ
cord-015021-pol2qm74	4266	5	in	in	IN
cord-015021-pol2qm74	4266	6	all	all	DT
cord-015021-pol2qm74	4266	7	patients	patient	NNS
cord-015021-pol2qm74	4266	8	and	and	CC
cord-015021-pol2qm74	4266	9	none	none	NN
cord-015021-pol2qm74	4266	10	were	be	VBD
cord-015021-pol2qm74	4266	11	matnourished	matnourishe	VBN
cord-015021-pol2qm74	4266	12	.	.	.
cord-015021-pol2qm74	4267	1	On	on	IN
cord-015021-pol2qm74	4267	2	the	the	DT
cord-015021-pol2qm74	4267	3	day	day	NN
cord-015021-pol2qm74	4267	4	of	of	IN
cord-015021-pol2qm74	4267	5	surgery	surgery	NN
cord-015021-pol2qm74	4267	6	and	and	CC
cord-015021-pol2qm74	4267	7	on	on	IN
cord-015021-pol2qm74	4267	8	the	the	DT
cord-015021-pol2qm74	4267	9	1st	1st	JJ
cord-015021-pol2qm74	4267	10	and	and	CC
cord-015021-pol2qm74	4267	11	7th	7th	JJ
cord-015021-pol2qm74	4267	12	postoperative	postoperative	JJ
cord-015021-pol2qm74	4267	13	days	day	NNS
cord-015021-pol2qm74	4267	14	(	(	-LRB-
cord-015021-pol2qm74	4267	15	Pre	Pre	NNP
cord-015021-pol2qm74	4267	16	,	,	,
cord-015021-pol2qm74	4267	17	lPO	lPO	NNP
cord-015021-pol2qm74	4267	18	,	,	,
cord-015021-pol2qm74	4267	19	7PO	7PO	NNP
cord-015021-pol2qm74	4267	20	)	)	-RRB-
cord-015021-pol2qm74	4267	21	percentages	percentage	NNS
cord-015021-pol2qm74	4267	22	of	of	IN
cord-015021-pol2qm74	4267	23	CD19	CD19	NNP
cord-015021-pol2qm74	4267	24	,	,	,
cord-015021-pol2qm74	4267	25	CD5	CD5	NNP
cord-015021-pol2qm74	4267	26	,	,	,
cord-015021-pol2qm74	4267	27	CD4	CD4	NNP
cord-015021-pol2qm74	4267	28	,	,	,
cord-015021-pol2qm74	4267	29	CDS	CDS	NNP
cord-015021-pol2qm74	4267	30	,	,	,
cord-015021-pol2qm74	4267	31	CDI6	CDI6	NNP
cord-015021-pol2qm74	4267	32	were	be	VBD
cord-015021-pol2qm74	4267	33	measured	measure	VBN
cord-015021-pol2qm74	4267	34	by	by	IN
cord-015021-pol2qm74	4267	35	means	mean	NNS
cord-015021-pol2qm74	4267	36	of	of	IN
cord-015021-pol2qm74	4267	37	flow	flow	NN
cord-015021-pol2qm74	4267	38	cytometry	cytometry	NN
cord-015021-pol2qm74	4267	39	using	use	VBG
cord-015021-pol2qm74	4267	40	MoAb	MoAb	NNP
cord-015021-pol2qm74	4267	41	.	.	NNP
cord-015021-pol2qm74	4267	42	,	,	,
cord-015021-pol2qm74	4267	43	and	and	CC
cord-015021-pol2qm74	4267	44	levels	level	NNS
cord-015021-pol2qm74	4267	45	of	of	IN
cord-015021-pol2qm74	4267	46	Ig	Ig	NNP
cord-015021-pol2qm74	4267	47	A	A	NNP
cord-015021-pol2qm74	4267	48	,	,	,
cord-015021-pol2qm74	4267	49	lgG	lgG	NNP
cord-015021-pol2qm74	4267	50	,	,	,
cord-015021-pol2qm74	4267	51	IgM	IgM	NNP
cord-015021-pol2qm74	4267	52	,	,	,
cord-015021-pol2qm74	4267	53	IgE.	IgE.	NNP
cord-015021-pol2qm74	4267	54	by	by	IN
cord-015021-pol2qm74	4267	55	nephelometry	nephelometry	NNP
cord-015021-pol2qm74	4267	56	Cytokine	Cytokine	NNP
cord-015021-pol2qm74	4267	57	levels	level	NNS
cord-015021-pol2qm74	4267	58	in	in	IN
cord-015021-pol2qm74	4267	59	peripheral	peripheral	JJ
cord-015021-pol2qm74	4267	60	blood(IL-1	blood(IL-1	NNS
cord-015021-pol2qm74	4267	61	,	,	,
cord-015021-pol2qm74	4267	62	IL-2	IL-2	NNP
cord-015021-pol2qm74	4267	63	,	,	,
cord-015021-pol2qm74	4267	64	IL-4	IL-4	NNP
cord-015021-pol2qm74	4267	65	,	,	,
cord-015021-pol2qm74	4267	66	IL-6	IL-6	NNP
cord-015021-pol2qm74	4267	67	,	,	,
cord-015021-pol2qm74	4267	68	TNF	TNF	NNP
cord-015021-pol2qm74	4267	69	)	)	-RRB-
cord-015021-pol2qm74	4267	70	were	be	VBD
cord-015021-pol2qm74	4267	71	measured	measure	VBN
cord-015021-pol2qm74	4267	72	in	in	IN
cord-015021-pol2qm74	4267	73	10	10	CD
cord-015021-pol2qm74	4267	74	pts	pt	NNS
cord-015021-pol2qm74	4267	75	.	.	.
cord-015021-pol2qm74	4268	1	of	of	IN
cord-015021-pol2qm74	4268	2	each	each	DT
cord-015021-pol2qm74	4268	3	group	group	NN
cord-015021-pol2qm74	4268	4	by	by	IN
cord-015021-pol2qm74	4268	5	means	mean	NNS
cord-015021-pol2qm74	4268	6	of	of	IN
cord-015021-pol2qm74	4268	7	ELISA	ELISA	NNP
cord-015021-pol2qm74	4268	8	using	use	VBG
cord-015021-pol2qm74	4268	9	MoAb	MoAb	NNP
cord-015021-pol2qm74	4268	10	.	.	.
cord-015021-pol2qm74	4269	1	_	_	NNP
cord-015021-pol2qm74	4270	1	R.	R.	NNP
cord-015021-pol2qm74	4270	2	ESULTS	ESULTS	NNP
cord-015021-pol2qm74	4270	3	:	:	:
cord-015021-pol2qm74	4271	1	Variations	variation	NNS
cord-015021-pol2qm74	4271	2	of	of	IN
cord-015021-pol2qm74	4271	3	iL-2	il-2	NN
cord-015021-pol2qm74	4271	4	and	and	CC
cord-015021-pol2qm74	4272	1	IL-4	IL-4	NNP
cord-015021-pol2qm74	4272	2	were	be	VBD
cord-015021-pol2qm74	4272	3	not	not	RB
cord-015021-pol2qm74	4272	4	s.s	s.s	NNP
cord-015021-pol2qm74	4272	5	..	..	.
cord-015021-pol2qm74	4273	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	4273	2	increased	increase	VBD
cord-015021-pol2qm74	4273	3	but	but	CC
cord-015021-pol2qm74	4273	4	differences	difference	NNS
cord-015021-pol2qm74	4273	5	between	between	IN
cord-015021-pol2qm74	4273	6	groups	group	NNS
cord-015021-pol2qm74	4273	7	were	be	VBD
cord-015021-pol2qm74	4273	8	not	not	RB
cord-015021-pol2qm74	4273	9	statistically	statistically	RB
cord-015021-pol2qm74	4273	10	significant	significant	JJ
cord-015021-pol2qm74	4273	11	(	(	-LRB-
cord-015021-pol2qm74	4273	12	s.s	s.s	NNP
cord-015021-pol2qm74	4273	13	)	)	-RRB-
cord-015021-pol2qm74	4273	14	.	.	.
cord-015021-pol2qm74	4274	1	IL	IL	NNP
cord-015021-pol2qm74	4274	2	-	-	:
cord-015021-pol2qm74	4274	3	I	-PRON-	PRP
cord-015021-pol2qm74	4274	4	decreased	decrease	VBD
cord-015021-pol2qm74	4274	5	on	on	IN
cord-015021-pol2qm74	4274	6	1PO	1po	CD
cord-015021-pol2qm74	4274	7	and	and	CC
cord-015021-pol2qm74	4274	8	increased	increase	VBD
cord-015021-pol2qm74	4274	9	on	on	IN
cord-015021-pol2qm74	4274	10	7PO	7PO	NNP
cord-015021-pol2qm74	4274	11	in	in	IN
cord-015021-pol2qm74	4274	12	both	both	DT
cord-015021-pol2qm74	4274	13	groups	group	NNS
cord-015021-pol2qm74	4274	14	but	but	CC
cord-015021-pol2qm74	4274	15	were	be	VBD
cord-015021-pol2qm74	4274	16	only	only	RB
cord-015021-pol2qm74	4274	17	s.s	s.s	NNP
cord-015021-pol2qm74	4274	18	.	.	NNP
cord-015021-pol2qm74	4274	19	in	in	IN
cord-015021-pol2qm74	4274	20	the	the	DT
cord-015021-pol2qm74	4274	21	TH.g	TH.g	NNP
cord-015021-pol2qm74	4274	22	.	.	NNP
cord-015021-pol2qm74	4274	23	,	,	,
cord-015021-pol2qm74	4274	24	and	and	CC
cord-015021-pol2qm74	4274	25	therefore	therefore	RB
cord-015021-pol2qm74	4274	26	,	,	,
cord-015021-pol2qm74	4274	27	the	the	DT
cord-015021-pol2qm74	4274	28	differences	difference	NNS
cord-015021-pol2qm74	4274	29	between	between	IN
cord-015021-pol2qm74	4274	30	groups	group	NNS
cord-015021-pol2qm74	4274	31	were	be	VBD
cord-015021-pol2qm74	4275	1	s.s	s.s	NNP
cord-015021-pol2qm74	4275	2	(	(	-LRB-
cord-015021-pol2qm74	4275	3	P<0.05).TNF	P<0.05).TNF	NNP
cord-015021-pol2qm74	4275	4	decreased	decrease	VBD
cord-015021-pol2qm74	4275	5	in	in	IN
cord-015021-pol2qm74	4275	6	the	the	DT
cord-015021-pol2qm74	4275	7	L.g	l.g	NN
cord-015021-pol2qm74	4275	8	.	.	.
cord-015021-pol2qm74	4276	1	and	and	CC
cord-015021-pol2qm74	4276	2	increased	increase	VBD
cord-015021-pol2qm74	4276	3	in	in	IN
cord-015021-pol2qm74	4276	4	the	the	DT
cord-015021-pol2qm74	4276	5	Th.g	Th.g	NNP
cord-015021-pol2qm74	4276	6	.	.	.
cord-015021-pol2qm74	4277	1	on	on	IN
cord-015021-pol2qm74	4277	2	the	the	DT
cord-015021-pol2qm74	4277	3	1PO	1po	CD
cord-015021-pol2qm74	4277	4	,	,	,
cord-015021-pol2qm74	4277	5	the	the	DT
cord-015021-pol2qm74	4277	6	difference	difference	NN
cord-015021-pol2qm74	4277	7	was	be	VBD
cord-015021-pol2qm74	4277	8	s.s(P<0.05	s.s(P<0.05	NNP
cord-015021-pol2qm74	4277	9	)	)	-RRB-
cord-015021-pol2qm74	4277	10	;	;	:
cord-015021-pol2qm74	4277	11	on	on	IN
cord-015021-pol2qm74	4277	12	7PO	7PO	NNP
cord-015021-pol2qm74	4277	13	,	,	,
cord-015021-pol2qm74	4277	14	TNF	TNF	NNP
cord-015021-pol2qm74	4277	15	decreased	decrease	VBD
cord-015021-pol2qm74	4277	16	in	in	IN
cord-015021-pol2qm74	4277	17	the	the	DT
cord-015021-pol2qm74	4277	18	L.g	l.g	NN
cord-015021-pol2qm74	4277	19	.	.	.
cord-015021-pol2qm74	4278	1	and	and	CC
cord-015021-pol2qm74	4278	2	decreased	decrease	VBD
cord-015021-pol2qm74	4278	3	in	in	IN
cord-015021-pol2qm74	4278	4	the	the	DT
cord-015021-pol2qm74	4278	5	TH.g	TH.g	NNP
cord-015021-pol2qm74	4278	6	.	.	.
cord-015021-pol2qm74	4279	1	but	but	CC
cord-015021-pol2qm74	4279	2	these	these	DT
cord-015021-pol2qm74	4279	3	variations	variation	NNS
cord-015021-pol2qm74	4279	4	were	be	VBD
cord-015021-pol2qm74	4279	5	not	not	RB
cord-015021-pol2qm74	4279	6	s.s	s.s	NNP
cord-015021-pol2qm74	4279	7	.	.	.
cord-015021-pol2qm74	4280	1	Cell	cell	NN
cord-015021-pol2qm74	4280	2	percentages	percentage	NNS
cord-015021-pol2qm74	4280	3	decreased	decrease	VBD
cord-015021-pol2qm74	4280	4	an	an	DT
cord-015021-pol2qm74	4280	5	lPO	lpo	NN
cord-015021-pol2qm74	4280	6	and	and	CC
cord-015021-pol2qm74	4280	7	increased	increase	VBD
cord-015021-pol2qm74	4280	8	on	on	IN
cord-015021-pol2qm74	4280	9	7PO	7PO	NNP
cord-015021-pol2qm74	4280	10	,	,	,
cord-015021-pol2qm74	4280	11	except	except	IN
cord-015021-pol2qm74	4280	12	for	for	IN
cord-015021-pol2qm74	4280	13	%	%	NN
cord-015021-pol2qm74	4280	14	CD19	CD19	NNP
cord-015021-pol2qm74	4280	15	cell	cell	NN
cord-015021-pol2qm74	4280	16	that	that	WDT
cord-015021-pol2qm74	4280	17	increased	increase	VBD
cord-015021-pol2qm74	4280	18	on	on	IN
cord-015021-pol2qm74	4280	19	lPO	lpo	NN
cord-015021-pol2qm74	4280	20	and	and	CC
cord-015021-pol2qm74	4280	21	decreased	decrease	VBD
cord-015021-pol2qm74	4280	22	on	on	IN
cord-015021-pol2qm74	4280	23	7PO	7PO	NNP
cord-015021-pol2qm74	4280	24	,	,	,
cord-015021-pol2qm74	4280	25	in	in	IN
cord-015021-pol2qm74	4280	26	both	both	DT
cord-015021-pol2qm74	4280	27	groups	group	NNS
cord-015021-pol2qm74	4280	28	of	of	IN
cord-015021-pol2qm74	4280	29	pts	pt	NNS
cord-015021-pol2qm74	4280	30	.	.	.
cord-015021-pol2qm74	4281	1	Differences	difference	NNS
cord-015021-pol2qm74	4281	2	were	be	VBD
cord-015021-pol2qm74	4281	3	not	not	RB
cord-015021-pol2qm74	4281	4	s.s	s.s	NNP
cord-015021-pol2qm74	4281	5	.	.	.
cord-015021-pol2qm74	4282	1	Ig	Ig	NNP
cord-015021-pol2qm74	4282	2	A	A	NNP
cord-015021-pol2qm74	4282	3	,	,	,
cord-015021-pol2qm74	4282	4	IgM	IgM	NNP
cord-015021-pol2qm74	4282	5	decreased	decrease	VBD
cord-015021-pol2qm74	4282	6	and	and	CC
cord-015021-pol2qm74	4282	7	IgE	IgE	NNP
cord-015021-pol2qm74	4282	8	increased	increase	VBD
cord-015021-pol2qm74	4282	9	in	in	IN
cord-015021-pol2qm74	4282	10	both	both	DT
cord-015021-pol2qm74	4282	11	groups	group	NNS
cord-015021-pol2qm74	4282	12	(	(	-LRB-
cord-015021-pol2qm74	4282	13	P	p	NN
cord-015021-pol2qm74	4282	14	<	<	XX
cord-015021-pol2qm74	4282	15	0.0i	0.0i	CD
cord-015021-pol2qm74	4282	16	)	)	-RRB-
cord-015021-pol2qm74	4282	17	,	,	,
cord-015021-pol2qm74	4282	18	but	but	CC
cord-015021-pol2qm74	4282	19	differences	difference	NNS
cord-015021-pol2qm74	4282	20	between	between	IN
cord-015021-pol2qm74	4282	21	them	-PRON-	PRP
cord-015021-pol2qm74	4282	22	were	be	VBD
cord-015021-pol2qm74	4282	23	not	not	RB
cord-015021-pol2qm74	4282	24	s.s	s.s	NNP
cord-015021-pol2qm74	4282	25	.	.	.
cord-015021-pol2qm74	4283	1	In	in	IN
cord-015021-pol2qm74	4283	2	contrast	contrast	NN
cord-015021-pol2qm74	4283	3	,	,	,
cord-015021-pol2qm74	4283	4	IgG	igg	NN
cord-015021-pol2qm74	4283	5	decreased	decrease	VBD
cord-015021-pol2qm74	4283	6	on	on	IN
cord-015021-pol2qm74	4283	7	1PO	1po	CD
cord-015021-pol2qm74	4283	8	(	(	-LRB-
cord-015021-pol2qm74	4283	9	P<0.01	P<0.01	NNP
cord-015021-pol2qm74	4283	10	)	)	-RRB-
cord-015021-pol2qm74	4283	11	and	and	CC
cord-015021-pol2qm74	4283	12	increased	increase	VBD
cord-015021-pol2qm74	4283	13	on	on	IN
cord-015021-pol2qm74	4283	14	7PO	7PO	NNP
cord-015021-pol2qm74	4283	15	in	in	IN
cord-015021-pol2qm74	4283	16	both	both	DT
cord-015021-pol2qm74	4283	17	groups	group	NNS
cord-015021-pol2qm74	4283	18	,	,	,
cord-015021-pol2qm74	4283	19	but	but	CC
cord-015021-pol2qm74	4283	20	the	the	DT
cord-015021-pol2qm74	4283	21	decrease	decrease	NN
cord-015021-pol2qm74	4283	22	iu	iu	IN
cord-015021-pol2qm74	4283	23	the	the	DT
cord-015021-pol2qm74	4283	24	TH.g	TH.g	NNP
cord-015021-pol2qm74	4283	25	.	.	.
cord-015021-pol2qm74	4283	26	was	be	VBD
cord-015021-pol2qm74	4283	27	greater	great	JJR
cord-015021-pol2qm74	4283	28	than	than	IN
cord-015021-pol2qm74	4283	29	in	in	IN
cord-015021-pol2qm74	4283	30	the	the	DT
cord-015021-pol2qm74	4283	31	L.g	l.g	NN
cord-015021-pol2qm74	4283	32	.	.	.
cord-015021-pol2qm74	4284	1	Twenty	twenty	CD
cord-015021-pol2qm74	4284	2	male	male	JJ
cord-015021-pol2qm74	4284	3	children	child	NNS
cord-015021-pol2qm74	4284	4	,	,	,
cord-015021-pol2qm74	4284	5	aged	age	VBN
cord-015021-pol2qm74	4284	6	from	from	IN
cord-015021-pol2qm74	4284	7	six	six	CD
cord-015021-pol2qm74	4284	8	months	month	NNS
cord-015021-pol2qm74	4284	9	to	to	IN
cord-015021-pol2qm74	4284	10	3	3	CD
cord-015021-pol2qm74	4284	11	years	year	NNS
cord-015021-pol2qm74	4284	12	,	,	,
cord-015021-pol2qm74	4284	13	admitted	admit	VBN
cord-015021-pol2qm74	4284	14	for	for	IN
cord-015021-pol2qm74	4284	15	elective	elective	JJ
cord-015021-pol2qm74	4284	16	inguinal	inguinal	JJ
cord-015021-pol2qm74	4284	17	operation	operation	NN
cord-015021-pol2qm74	4284	18	were	be	VBD
cord-015021-pol2qm74	4284	19	studied	study	VBN
cord-015021-pol2qm74	4284	20	.	.	.
cord-015021-pol2qm74	4285	1	The	the	DT
cord-015021-pol2qm74	4285	2	operations	operation	NNS
cord-015021-pol2qm74	4285	3	were	be	VBD
cord-015021-pol2qm74	4285	4	performed	perform	VBN
cord-015021-pol2qm74	4285	5	under	under	IN
cord-015021-pol2qm74	4285	6	balanced	balanced	JJ
cord-015021-pol2qm74	4285	7	combined	combined	JJ
cord-015021-pol2qm74	4285	8	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4285	9	(	(	-LRB-
cord-015021-pol2qm74	4285	10	fentanyl	fentanyl	NN
cord-015021-pol2qm74	4285	11	,	,	,
cord-015021-pol2qm74	4285	12	thiopemtone	thiopemtone	NN
cord-015021-pol2qm74	4285	13	,	,	,
cord-015021-pol2qm74	4285	14	vecuronium	vecuronium	NNP
cord-015021-pol2qm74	4285	15	,	,	,
cord-015021-pol2qm74	4285	16	70	70	CD
cord-015021-pol2qm74	4285	17	%	%	NN
cord-015021-pol2qm74	4285	18	nitrous	nitrous	JJ
cord-015021-pol2qm74	4285	19	oxide	oxide	NN
cord-015021-pol2qm74	4285	20	in	in	IN
cord-015021-pol2qm74	4285	21	oxygen	oxygen	NN
cord-015021-pol2qm74	4285	22	)	)	-RRB-
cord-015021-pol2qm74	4285	23	and	and	CC
cord-015021-pol2qm74	4285	24	blood	blood	NN
cord-015021-pol2qm74	4285	25	samples	sample	NNS
cord-015021-pol2qm74	4285	26	were	be	VBD
cord-015021-pol2qm74	4285	27	collected	collect	VBN
cord-015021-pol2qm74	4285	28	before	before	IN
cord-015021-pol2qm74	4285	29	flunitrazepam	flunitrazepam	NN
cord-015021-pol2qm74	4285	30	premedication	premedication	NN
cord-015021-pol2qm74	4285	31	,	,	,
cord-015021-pol2qm74	4285	32	after	after	IN
cord-015021-pol2qm74	4285	33	anaesthesia,4	anaesthesia,4	NN
cord-015021-pol2qm74	4285	34	and	and	CC
cord-015021-pol2qm74	4285	35	24	24	CD
cord-015021-pol2qm74	4285	36	hours	hour	NNS
cord-015021-pol2qm74	4285	37	after	after	IN
cord-015021-pol2qm74	4285	38	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4285	39	.	.	.
cord-015021-pol2qm74	4286	1	Cells	cell	NNS
cord-015021-pol2qm74	4286	2	from	from	IN
cord-015021-pol2qm74	4286	3	the	the	DT
cord-015021-pol2qm74	4286	4	wound	wound	NN
cord-015021-pol2qm74	4286	5	were	be	VBD
cord-015021-pol2qm74	4286	6	collected	collect	VBN
cord-015021-pol2qm74	4286	7	with	with	IN
cord-015021-pol2qm74	4286	8	Cellstick	Cellstick	NNP
cord-015021-pol2qm74	4286	9	sponge	sponge	NN
cord-015021-pol2qm74	4286	10	which	which	WDT
cord-015021-pol2qm74	4286	11	was	be	VBD
cord-015021-pol2qm74	4286	12	removed	remove	VBN
cord-015021-pol2qm74	4286	13	from	from	IN
cord-015021-pol2qm74	4286	14	the	the	DT
cord-015021-pol2qm74	4286	15	wound	wound	NN
cord-015021-pol2qm74	4286	16	4	4	CD
cord-015021-pol2qm74	4286	17	or	or	CC
cord-015021-pol2qm74	4286	18	24	24	CD
cord-015021-pol2qm74	4286	19	hours	hour	NNS
cord-015021-pol2qm74	4286	20	after	after	IN
cord-015021-pol2qm74	4286	21	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4286	22	.	.	.
cord-015021-pol2qm74	4287	1	The	the	DT
cord-015021-pol2qm74	4287	2	study	study	NN
cord-015021-pol2qm74	4287	3	was	be	VBD
cord-015021-pol2qm74	4287	4	approved	approve	VBN
cord-015021-pol2qm74	4287	5	by	by	IN
cord-015021-pol2qm74	4287	6	the	the	DT
cord-015021-pol2qm74	4287	7	local	local	JJ
cord-015021-pol2qm74	4287	8	Ethical	Ethical	NNP
cord-015021-pol2qm74	4287	9	Committee	Committee	NNP
cord-015021-pol2qm74	4287	10	.	.	.
cord-015021-pol2qm74	4288	1	The	the	DT
cord-015021-pol2qm74	4288	2	percentage	percentage	NN
cord-015021-pol2qm74	4288	3	of	of	IN
cord-015021-pol2qm74	4288	4	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4288	5	was	be	VBD
cord-015021-pol2qm74	4288	6	increased	increase	VBN
cord-015021-pol2qm74	4288	7	and	and	CC
cord-015021-pol2qm74	4288	8	that	that	IN
cord-015021-pol2qm74	4288	9	of	of	IN
cord-015021-pol2qm74	4288	10	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4288	11	was	be	VBD
cord-015021-pol2qm74	4288	12	decreased	decrease	VBN
cord-015021-pol2qm74	4288	13	in	in	IN
cord-015021-pol2qm74	4288	14	perpheral	perpheral	JJ
cord-015021-pol2qm74	4288	15	blood	blood	NN
cord-015021-pol2qm74	4288	16	after	after	IN
cord-015021-pol2qm74	4288	17	the	the	DT
cord-015021-pol2qm74	4288	18	operation	operation	NN
cord-015021-pol2qm74	4288	19	.	.	.
cord-015021-pol2qm74	4289	1	The	the	DT
cord-015021-pol2qm74	4289	2	values	value	NNS
cord-015021-pol2qm74	4289	3	in	in	IN
cord-015021-pol2qm74	4289	4	the	the	DT
cord-015021-pol2qm74	4289	5	wound	wound	NN
cord-015021-pol2qm74	4289	6	were	be	VBD
cord-015021-pol2qm74	4289	7	close	close	JJ
cord-015021-pol2qm74	4289	8	to	to	IN
cord-015021-pol2qm74	4289	9	the	the	DT
cord-015021-pol2qm74	4289	10	values	value	NNS
cord-015021-pol2qm74	4289	11	found	find	VBN
cord-015021-pol2qm74	4289	12	in	in	IN
cord-015021-pol2qm74	4289	13	peripheral	peripheral	JJ
cord-015021-pol2qm74	4289	14	blood	blood	NN
cord-015021-pol2qm74	4289	15	.	.	.
cord-015021-pol2qm74	4290	1	The	the	DT
cord-015021-pol2qm74	4290	2	percentage	percentage	NN
cord-015021-pol2qm74	4290	3	of	of	IN
cord-015021-pol2qm74	4290	4	T	t	NN
cord-015021-pol2qm74	4290	5	-	-	HYPH
cord-015021-pol2qm74	4290	6	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4290	7	(	(	-LRB-
cord-015021-pol2qm74	4290	8	CD3	CD3	NNP
cord-015021-pol2qm74	4290	9	)	)	-RRB-
cord-015021-pol2qm74	4290	10	and	and	CC
cord-015021-pol2qm74	4290	11	helper	helper	NN
cord-015021-pol2qm74	4290	12	-	-	HYPH
cord-015021-pol2qm74	4290	13	T	t	NN
cord-015021-pol2qm74	4290	14	-	-	HYPH
cord-015021-pol2qm74	4290	15	cells	cell	NNS
cord-015021-pol2qm74	4290	16	(	(	-LRB-
cord-015021-pol2qm74	4290	17	CD4	CD4	NNP
cord-015021-pol2qm74	4290	18	)	)	-RRB-
cord-015021-pol2qm74	4290	19	decreased	decrease	VBD
cord-015021-pol2qm74	4290	20	in	in	IN
cord-015021-pol2qm74	4290	21	peripheral	peripheral	JJ
cord-015021-pol2qm74	4290	22	blood	blood	NN
cord-015021-pol2qm74	4290	23	being	be	VBG
cord-015021-pol2qm74	4290	24	lower	low	JJR
cord-015021-pol2qm74	4290	25	in	in	IN
cord-015021-pol2qm74	4290	26	the	the	DT
cord-015021-pol2qm74	4290	27	wound	wound	NN
cord-015021-pol2qm74	4290	28	than	than	IN
cord-015021-pol2qm74	4290	29	in	in	IN
cord-015021-pol2qm74	4290	30	peripheral	peripheral	JJ
cord-015021-pol2qm74	4290	31	blood	blood	NN
cord-015021-pol2qm74	4290	32	after	after	IN
cord-015021-pol2qm74	4290	33	the	the	DT
cord-015021-pol2qm74	4290	34	operation	operation	NN
cord-015021-pol2qm74	4290	35	.	.	.
cord-015021-pol2qm74	4291	1	The	the	DT
cord-015021-pol2qm74	4291	2	percentage	percentage	NN
cord-015021-pol2qm74	4291	3	of	of	IN
cord-015021-pol2qm74	4291	4	T	T	NNP
cord-015021-pol2qm74	4291	5	-	-	HYPH
cord-015021-pol2qm74	4291	6	eytotoxic	eytotoxic	NNP
cord-015021-pol2qm74	4291	7	cells	cell	NNS
cord-015021-pol2qm74	4291	8	(	(	-LRB-
cord-015021-pol2qm74	4291	9	CD8	CD8	NNP
cord-015021-pol2qm74	4291	10	)	)	-RRB-
cord-015021-pol2qm74	4291	11	also	also	RB
cord-015021-pol2qm74	4291	12	decreased	decrease	VBD
cord-015021-pol2qm74	4291	13	in	in	IN
cord-015021-pol2qm74	4291	14	peripheral	peripheral	JJ
cord-015021-pol2qm74	4291	15	blood	blood	NN
cord-015021-pol2qm74	4291	16	and	and	CC
cord-015021-pol2qm74	4291	17	was	be	VBD
cord-015021-pol2qm74	4291	18	similar	similar	JJ
cord-015021-pol2qm74	4291	19	to	to	IN
cord-015021-pol2qm74	4291	20	that	that	DT
cord-015021-pol2qm74	4291	21	in	in	IN
cord-015021-pol2qm74	4291	22	the	the	DT
cord-015021-pol2qm74	4291	23	wound	wound	NN
cord-015021-pol2qm74	4291	24	.	.	.
cord-015021-pol2qm74	4292	1	B	b	NN
cord-015021-pol2qm74	4292	2	-	-	HYPH
cord-015021-pol2qm74	4292	3	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4292	4	(	(	-LRB-
cord-015021-pol2qm74	4292	5	CD19	CD19	NNP
cord-015021-pol2qm74	4292	6	)	)	-RRB-
cord-015021-pol2qm74	4292	7	percentage	percentage	NN
cord-015021-pol2qm74	4292	8	was	be	VBD
cord-015021-pol2qm74	4292	9	increased	increase	VBN
cord-015021-pol2qm74	4292	10	in	in	IN
cord-015021-pol2qm74	4292	11	pe	pe	NNP
cord-015021-pol2qm74	4292	12	~	~	CD
cord-015021-pol2qm74	4292	13	pheral	pheral	JJ
cord-015021-pol2qm74	4292	14	blood	blood	NN
cord-015021-pol2qm74	4292	15	after	after	IN
cord-015021-pol2qm74	4292	16	the	the	DT
cord-015021-pol2qm74	4292	17	operation	operation	NN
cord-015021-pol2qm74	4292	18	and	and	CC
cord-015021-pol2qm74	4292	19	was	be	VBD
cord-015021-pol2qm74	4292	20	higher	high	JJR
cord-015021-pol2qm74	4292	21	than	than	IN
cord-015021-pol2qm74	4292	22	in	in	IN
cord-015021-pol2qm74	4292	23	the	the	DT
cord-015021-pol2qm74	4292	24	wound	wound	NN
cord-015021-pol2qm74	4292	25	.	.	.
cord-015021-pol2qm74	4293	1	The	the	DT
cord-015021-pol2qm74	4293	2	percentage	percentage	NN
cord-015021-pol2qm74	4293	3	of	of	IN
cord-015021-pol2qm74	4293	4	activated	activate	VBN
cord-015021-pol2qm74	4293	5	T	T	NNP
cord-015021-pol2qm74	4293	6	-	-	HYPH
cord-015021-pol2qm74	4293	7	cells	cell	NNS
cord-015021-pol2qm74	4293	8	(	(	-LRB-
cord-015021-pol2qm74	4293	9	CD3+HLA	CD3+HLA	NNP
cord-015021-pol2qm74	4293	10	-	-	HYPH
cord-015021-pol2qm74	4293	11	Dr	Dr	NNP
cord-015021-pol2qm74	4293	12	-	-	HYPH
cord-015021-pol2qm74	4293	13	positive	positive	JJ
cord-015021-pol2qm74	4293	14	cells	cell	NNS
cord-015021-pol2qm74	4293	15	)	)	-RRB-
cord-015021-pol2qm74	4293	16	in	in	IN
cord-015021-pol2qm74	4293	17	peripheral	peripheral	JJ
cord-015021-pol2qm74	4293	18	blood	blood	NN
cord-015021-pol2qm74	4293	19	increased	increase	VBD
cord-015021-pol2qm74	4293	20	while	while	IN
cord-015021-pol2qm74	4293	21	that	that	DT
cord-015021-pol2qm74	4293	22	of	of	IN
cord-015021-pol2qm74	4293	23	natural	natural	JJ
cord-015021-pol2qm74	4293	24	killer	killer	NN
cord-015021-pol2qm74	4293	25	cells	cell	NNS
cord-015021-pol2qm74	4293	26	(	(	-LRB-
cord-015021-pol2qm74	4293	27	CD3+CD16+Leu19-pos	cd3+cd16+leu19-pos	NN
cord-015021-pol2qm74	4293	28	)	)	-RRB-
cord-015021-pol2qm74	4293	29	was	be	VBD
cord-015021-pol2qm74	4293	30	increased	increase	VBN
cord-015021-pol2qm74	4293	31	just	just	RB
cord-015021-pol2qm74	4293	32	after	after	IN
cord-015021-pol2qm74	4293	33	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4293	34	being	being	NN
cord-015021-pol2qm74	4293	35	decreased	decrease	VBD
cord-015021-pol2qm74	4293	36	at	at	IN
cord-015021-pol2qm74	4293	37	g	g	NN
cord-015021-pol2qm74	4293	38	and	and	CC
cord-015021-pol2qm74	4293	39	24	24	CD
cord-015021-pol2qm74	4293	40	hours	hour	NNS
cord-015021-pol2qm74	4293	41	after	after	IN
cord-015021-pol2qm74	4293	42	the	the	DT
cord-015021-pol2qm74	4293	43	operation	operation	NN
cord-015021-pol2qm74	4293	44	.	.	.
cord-015021-pol2qm74	4294	1	Spontaneous	spontaneous	JJ
cord-015021-pol2qm74	4294	2	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4294	3	proliferative	proliferative	JJ
cord-015021-pol2qm74	4294	4	responses	response	NNS
cord-015021-pol2qm74	4294	5	did	do	VBD
cord-015021-pol2qm74	4294	6	n't	not	RB
cord-015021-pol2qm74	4294	7	change	change	VB
cord-015021-pol2qm74	4294	8	while	while	IN
cord-015021-pol2qm74	4294	9	phytohemagglutinin	phytohemagglutinin	NNP
cord-015021-pol2qm74	4294	10	A	A	NNP
cord-015021-pol2qm74	4294	11	and	and	CC
cord-015021-pol2qm74	4294	12	concavalin	concavalin	NN
cord-015021-pol2qm74	4294	13	A	a	DT
cord-015021-pol2qm74	4294	14	induced	induce	VBN
cord-015021-pol2qm74	4294	15	responses	response	NNS
cord-015021-pol2qm74	4294	16	were	be	VBD
cord-015021-pol2qm74	4294	17	decreased	decrease	VBN
cord-015021-pol2qm74	4294	18	in	in	IN
cord-015021-pol2qm74	4294	19	peripheral	peripheral	JJ
cord-015021-pol2qm74	4294	20	blood	blood	NN
cord-015021-pol2qm74	4294	21	samples	sample	NNS
cord-015021-pol2qm74	4294	22	4	4	CD
cord-015021-pol2qm74	4294	23	hours	hour	NNS
cord-015021-pol2qm74	4294	24	after	after	IN
cord-015021-pol2qm74	4294	25	the	the	DT
cord-015021-pol2qm74	4294	26	operation	operation	NN
cord-015021-pol2qm74	4294	27	with	with	IN
cord-015021-pol2qm74	4294	28	recovery	recovery	NN
cord-015021-pol2qm74	4294	29	at	at	IN
cord-015021-pol2qm74	4294	30	24	24	CD
cord-015021-pol2qm74	4294	31	hours	hour	NNS
cord-015021-pol2qm74	4294	32	.	.	.
cord-015021-pol2qm74	4295	1	Pokeweed	pokeweed	JJ
cord-015021-pol2qm74	4295	2	mitogen	mitogen	NN
cord-015021-pol2qm74	4295	3	induced	induce	VBN
cord-015021-pol2qm74	4295	4	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4295	5	proliferative	proliferative	JJ
cord-015021-pol2qm74	4295	6	responses	response	NNS
cord-015021-pol2qm74	4295	7	were	be	VBD
cord-015021-pol2qm74	4295	8	decreased	decrease	VBN
cord-015021-pol2qm74	4295	9	at	at	IN
cord-015021-pol2qm74	4295	10	4	4	CD
cord-015021-pol2qm74	4295	11	hours	hour	NNS
cord-015021-pol2qm74	4295	12	(	(	-LRB-
cord-015021-pol2qm74	4295	13	p	p	NN
cord-015021-pol2qm74	4295	14	<	<	XX
cord-015021-pol2qm74	4295	15	O.01	o.01	CD
cord-015021-pol2qm74	4295	16	)	)	-RRB-
cord-015021-pol2qm74	4295	17	and	and	CC
cord-015021-pol2qm74	4295	18	24	24	CD
cord-015021-pol2qm74	4295	19	hours	hour	NNS
cord-015021-pol2qm74	4295	20	after	after	IN
cord-015021-pol2qm74	4295	21	the	the	DT
cord-015021-pol2qm74	4295	22	operation	operation	NN
cord-015021-pol2qm74	4296	1	We	-PRON-	PRP
cord-015021-pol2qm74	4296	2	previously	previously	RB
cord-015021-pol2qm74	4296	3	reported	report	VBD
cord-015021-pol2qm74	4296	4	that	that	IN
cord-015021-pol2qm74	4296	5	plasma	plasma	NNP
cord-015021-pol2qm74	4296	6	IgE	IgE	NNP
cord-015021-pol2qm74	4296	7	increased	increase	VBD
cord-015021-pol2qm74	4296	8	after	after	IN
cord-015021-pol2qm74	4296	9	traumatic	traumatic	JJ
cord-015021-pol2qm74	4296	10	injury	injury	NN
cord-015021-pol2qm74	4296	11	.	.	.
cord-015021-pol2qm74	4297	1	In	in	IN
cord-015021-pol2qm74	4297	2	this	this	DT
cord-015021-pol2qm74	4297	3	study	study	NN
cord-015021-pol2qm74	4297	4	,	,	,
cord-015021-pol2qm74	4297	5	we	-PRON-	PRP
cord-015021-pol2qm74	4297	6	measured	measure	VBD
cord-015021-pol2qm74	4297	7	plasma	plasma	NNP
cord-015021-pol2qm74	4297	8	IgE	IgE	NNP
cord-015021-pol2qm74	4297	9	Ievels	Ievels	NNP
cord-015021-pol2qm74	4297	10	in	in	IN
cord-015021-pol2qm74	4297	11	40	40	CD
cord-015021-pol2qm74	4297	12	trauma	trauma	NN
cord-015021-pol2qm74	4297	13	patients	patient	NNS
cord-015021-pol2qm74	4297	14	on	on	IN
cord-015021-pol2qm74	4297	15	hospital	hospital	NN
cord-015021-pol2qm74	4297	16	admission	admission	NN
cord-015021-pol2qm74	4297	17	and	and	CC
cord-015021-pol2qm74	4297	18	3x	3x	CD
cord-015021-pol2qm74	4297	19	weekly	weekly	NN
cord-015021-pol2qm74	4297	20	in	in	IN
cord-015021-pol2qm74	4297	21	the	the	DT
cord-015021-pol2qm74	4297	22	intensive	intensive	JJ
cord-015021-pol2qm74	4297	23	care	care	NN
cord-015021-pol2qm74	4297	24	unit	unit	NN
cord-015021-pol2qm74	4297	25	to	to	TO
cord-015021-pol2qm74	4297	26	evaluate	evaluate	VB
cord-015021-pol2qm74	4297	27	IgE	IgE	NNP
cord-015021-pol2qm74	4297	28	kinetics	kinetics	NNP
cord-015021-pol2qm74	4297	29	.	.	.
cord-015021-pol2qm74	4298	1	Patient	patient	JJ
cord-015021-pol2qm74	4298	2	characteristics	characteristic	NNS
cord-015021-pol2qm74	4298	3	were	be	VBD
cord-015021-pol2qm74	4298	4	:	:	:
cord-015021-pol2qm74	4298	5	mean	mean	VB
cord-015021-pol2qm74	4298	6	age	age	NN
cord-015021-pol2qm74	4298	7	36-+	36-+	CD
cord-015021-pol2qm74	4298	8	16	16	CD
cord-015021-pol2qm74	4298	9	years	year	NNS
cord-015021-pol2qm74	4298	10	(	(	-LRB-
cord-015021-pol2qm74	4298	11	33	33	CD
cord-015021-pol2qm74	4298	12	m	m	NN
cord-015021-pol2qm74	4298	13	,	,	,
cord-015021-pol2qm74	4298	14	9	9	CD
cord-015021-pol2qm74	4298	15	f	f	NNP
cord-015021-pol2qm74	4298	16	)	)	-RRB-
cord-015021-pol2qm74	4298	17	,	,	.
cord-015021-pol2qm74	4299	1	mean	mean	VB
cord-015021-pol2qm74	4299	2	Injury	injury	NN
cord-015021-pol2qm74	4299	3	Severity	severity	NN
cord-015021-pol2qm74	4299	4	Score	score	NN
cord-015021-pol2qm74	4299	5	(	(	-LRB-
cord-015021-pol2qm74	4299	6	ISS	ISS	NNP
cord-015021-pol2qm74	4299	7	)	)	-RRB-
cord-015021-pol2qm74	4299	8	26	26	CD
cord-015021-pol2qm74	4299	9	+	+	SYM
cord-015021-pol2qm74	4299	10	10	10	CD
cord-015021-pol2qm74	4299	11	,	,	,
cord-015021-pol2qm74	4299	12	sepsis	sepsis	NN
cord-015021-pol2qm74	4299	13	(	(	-LRB-
cord-015021-pol2qm74	4299	14	19	19	CD
cord-015021-pol2qm74	4299	15	patients	patient	NNS
cord-015021-pol2qm74	4299	16	)	)	-RRB-
cord-015021-pol2qm74	4299	17	,	,	,
cord-015021-pol2qm74	4299	18	sepsis	sepsis	NN
cord-015021-pol2qm74	4299	19	syndrome	syndrome	NN
cord-015021-pol2qm74	4299	20	(	(	-LRB-
cord-015021-pol2qm74	4299	21	9	9	CD
cord-015021-pol2qm74	4299	22	patients	patient	NNS
cord-015021-pol2qm74	4299	23	)	)	-RRB-
cord-015021-pol2qm74	4299	24	,	,	,
cord-015021-pol2qm74	4299	25	ARDS	ARDS	NNP
cord-015021-pol2qm74	4299	26	(	(	-LRB-
cord-015021-pol2qm74	4299	27	4	4	CD
cord-015021-pol2qm74	4299	28	patients	patient	NNS
cord-015021-pol2qm74	4299	29	)	)	-RRB-
cord-015021-pol2qm74	4299	30	,	,	,
cord-015021-pol2qm74	4299	31	renal	renal	JJ
cord-015021-pol2qm74	4299	32	failure	failure	NN
cord-015021-pol2qm74	4299	33	(	(	-LRB-
cord-015021-pol2qm74	4299	34	5	5	CD
cord-015021-pol2qm74	4299	35	patients	patient	NNS
cord-015021-pol2qm74	4299	36	)	)	-RRB-
cord-015021-pol2qm74	4299	37	.	.	.
cord-015021-pol2qm74	4300	1	IgE	IgE	NNP
cord-015021-pol2qm74	4300	2	increased	increase	VBD
cord-015021-pol2qm74	4300	3	in	in	IN
cord-015021-pol2qm74	4300	4	28	28	CD
cord-015021-pol2qm74	4300	5	patients	patient	NNS
cord-015021-pol2qm74	4300	6	(	(	-LRB-
cord-015021-pol2qm74	4300	7	70	70	CD
cord-015021-pol2qm74	4300	8	%	%	NN
cord-015021-pol2qm74	4300	9	)	)	-RRB-
cord-015021-pol2qm74	4300	10	.	.	.
cord-015021-pol2qm74	4301	1	The	the	DT
cord-015021-pol2qm74	4301	2	mean	mean	JJ
cord-015021-pol2qm74	4301	3	increase	increase	NN
cord-015021-pol2qm74	4301	4	was	be	VBD
cord-015021-pol2qm74	4301	5	527	527	CD
cord-015021-pol2qm74	4301	6	ng	ng	NN
cord-015021-pol2qm74	4301	7	/	/	SYM
cord-015021-pol2qm74	4301	8	ml	ml	NN
cord-015021-pol2qm74	4301	9	(	(	-LRB-
cord-015021-pol2qm74	4301	10	range	range	NN
cord-015021-pol2qm74	4301	11	0	0	CD
cord-015021-pol2qm74	4301	12	to	to	IN
cord-015021-pol2qm74	4301	13	7362	7362	CD
cord-015021-pol2qm74	4301	14	ng	ng	NN
cord-015021-pol2qm74	4301	15	/	/	SYM
cord-015021-pol2qm74	4301	16	ml	ml	NN
cord-015021-pol2qm74	4301	17	;	;	:
cord-015021-pol2qm74	4302	1	95	95	CD
cord-015021-pol2qm74	4302	2	%	%	NN
cord-015021-pol2qm74	4302	3	CI	CI	NNP
cord-015021-pol2qm74	4302	4	was	be	VBD
cord-015021-pol2qm74	4302	5	160	160	CD
cord-015021-pol2qm74	4302	6	to	to	IN
cord-015021-pol2qm74	4302	7	895	895	CD
cord-015021-pol2qm74	4302	8	ng	ng	NN
cord-015021-pol2qm74	4302	9	/	/	SYM
cord-015021-pol2qm74	4302	10	ml	ml	NN
cord-015021-pol2qm74	4302	11	)	)	-RRB-
cord-015021-pol2qm74	4302	12	.	.	.
cord-015021-pol2qm74	4303	1	Increase	increase	VB
cord-015021-pol2qm74	4303	2	in	in	IN
cord-015021-pol2qm74	4303	3	plasma	plasma	NN
cord-015021-pol2qm74	4303	4	IgE	IgE	NNP
cord-015021-pol2qm74	4303	5	was	be	VBD
cord-015021-pol2qm74	4303	6	significantly	significantly	RB
cord-015021-pol2qm74	4303	7	greater	great	JJR
cord-015021-pol2qm74	4303	8	in	in	IN
cord-015021-pol2qm74	4303	9	patients	patient	NNS
cord-015021-pol2qm74	4303	10	with	with	IN
cord-015021-pol2qm74	4303	11	sepsis	sepsis	NN
cord-015021-pol2qm74	4303	12	syndrome	syndrome	NN
cord-015021-pol2qm74	4303	13	(	(	-LRB-
cord-015021-pol2qm74	4303	14	p=0.021	p=0.021	NNP
cord-015021-pol2qm74	4303	15	)	)	-RRB-
cord-015021-pol2qm74	4303	16	and	and	CC
cord-015021-pol2qm74	4303	17	renal	renal	JJ
cord-015021-pol2qm74	4303	18	failure	failure	NN
cord-015021-pol2qm74	4303	19	(	(	-LRB-
cord-015021-pol2qm74	4303	20	p<0.001	p<0.001	CD
cord-015021-pol2qm74	4303	21	)	)	-RRB-
cord-015021-pol2qm74	4303	22	.	.	.
cord-015021-pol2qm74	4304	1	Although	although	IN
cord-015021-pol2qm74	4304	2	mean	mean	NNP
cord-015021-pol2qm74	4304	3	plasma	plasma	NNP
cord-015021-pol2qm74	4304	4	IgE	IgE	NNP
cord-015021-pol2qm74	4304	5	was	be	VBD
cord-015021-pol2qm74	4304	6	higher	high	JJR
cord-015021-pol2qm74	4304	7	with	with	IN
cord-015021-pol2qm74	4304	8	ARDS	ARDS	NNP
cord-015021-pol2qm74	4304	9	,	,	,
cord-015021-pol2qm74	4304	10	pneumonia	pneumonia	NN
cord-015021-pol2qm74	4304	11	,	,	,
cord-015021-pol2qm74	4304	12	hepatic	hepatic	JJ
cord-015021-pol2qm74	4304	13	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4304	14	,	,	,
cord-015021-pol2qm74	4304	15	and	and	CC
cord-015021-pol2qm74	4304	16	shock	shock	NN
cord-015021-pol2qm74	4304	17	,	,	,
cord-015021-pol2qm74	4304	18	these	these	DT
cord-015021-pol2qm74	4304	19	differences	difference	NNS
cord-015021-pol2qm74	4304	20	were	be	VBD
cord-015021-pol2qm74	4304	21	not	not	RB
cord-015021-pol2qm74	4304	22	significant	significant	JJ
cord-015021-pol2qm74	4304	23	(	(	-LRB-
cord-015021-pol2qm74	4304	24	p>0.05	p>0.05	NNP
cord-015021-pol2qm74	4304	25	)	)	-RRB-
cord-015021-pol2qm74	4304	26	.	.	.
cord-015021-pol2qm74	4305	1	Plasma	plasma	NN
cord-015021-pol2qm74	4305	2	IgE	IgE	NNP
cord-015021-pol2qm74	4305	3	increase	increase	NN
cord-015021-pol2qm74	4305	4	was	be	VBD
cord-015021-pol2qm74	4305	5	not	not	RB
cord-015021-pol2qm74	4305	6	related	relate	VBN
cord-015021-pol2qm74	4305	7	to	to	IN
cord-015021-pol2qm74	4305	8	severity	severity	NN
cord-015021-pol2qm74	4305	9	of	of	IN
cord-015021-pol2qm74	4305	10	injury	injury	NN
cord-015021-pol2qm74	4305	11	by	by	IN
cord-015021-pol2qm74	4305	12	ISS	ISS	NNP
cord-015021-pol2qm74	4305	13	score	score	NN
cord-015021-pol2qm74	4306	1	(	(	-LRB-
cord-015021-pol2qm74	4306	2	p	p	NN
cord-015021-pol2qm74	4306	3	=	=	SYM
cord-015021-pol2qm74	4306	4	0.42	0.42	CD
cord-015021-pol2qm74	4306	5	)	)	-RRB-
cord-015021-pol2qm74	4306	6	.	.	.
cord-015021-pol2qm74	4307	1	The	the	DT
cord-015021-pol2qm74	4307	2	mean	mean	JJ
cord-015021-pol2qm74	4307	3	day	day	NN
cord-015021-pol2qm74	4307	4	to	to	IN
cord-015021-pol2qm74	4307	5	highest	high	JJS
cord-015021-pol2qm74	4307	6	IgE	IgE	NNP
cord-015021-pol2qm74	4307	7	was	be	VBD
cord-015021-pol2qm74	4307	8	9.1-+6.5	9.1-+6.5	CD
cord-015021-pol2qm74	4307	9	.	.	.
cord-015021-pol2qm74	4308	1	The	the	DT
cord-015021-pol2qm74	4308	2	day	day	NN
cord-015021-pol2qm74	4308	3	sepsis	sepsis	NN
cord-015021-pol2qm74	4308	4	was	be	VBD
cord-015021-pol2qm74	4308	5	first	first	RB
cord-015021-pol2qm74	4308	6	observed	observe	VBN
cord-015021-pol2qm74	4308	7	preceded	precede	VBD
cord-015021-pol2qm74	4308	8	the	the	DT
cord-015021-pol2qm74	4308	9	day	day	NN
cord-015021-pol2qm74	4308	10	of	of	IN
cord-015021-pol2qm74	4308	11	highest	high	JJS
cord-015021-pol2qm74	4308	12	IgE	IgE	NNP
cord-015021-pol2qm74	4308	13	by	by	IN
cord-015021-pol2qm74	4308	14	4.2	4.2	CD
cord-015021-pol2qm74	4308	15	+	+	SYM
cord-015021-pol2qm74	4308	16	6.6	6.6	CD
cord-015021-pol2qm74	4308	17	days	day	NNS
cord-015021-pol2qm74	4308	18	.	.	.
cord-015021-pol2qm74	4309	1	There	there	EX
cord-015021-pol2qm74	4309	2	was	be	VBD
cord-015021-pol2qm74	4309	3	a	a	DT
cord-015021-pol2qm74	4309	4	significant	significant	JJ
cord-015021-pol2qm74	4309	5	association	association	NN
cord-015021-pol2qm74	4309	6	between	between	IN
cord-015021-pol2qm74	4309	7	the	the	DT
cord-015021-pol2qm74	4309	8	day	day	NN
cord-015021-pol2qm74	4309	9	of	of	IN
cord-015021-pol2qm74	4309	10	sepsis	sepsis	NN
cord-015021-pol2qm74	4309	11	onset	onset	NN
cord-015021-pol2qm74	4309	12	and	and	CC
cord-015021-pol2qm74	4309	13	the	the	DT
cord-015021-pol2qm74	4309	14	day	day	NN
cord-015021-pol2qm74	4309	15	of	of	IN
cord-015021-pol2qm74	4309	16	highest	high	JJS
cord-015021-pol2qm74	4309	17	IgE	IgE	NNP
cord-015021-pol2qm74	4309	18	(	(	-LRB-
cord-015021-pol2qm74	4309	19	p=0.018	p=0.018	NNP
cord-015021-pol2qm74	4309	20	)	)	-RRB-
cord-015021-pol2qm74	4309	21	.	.	.
cord-015021-pol2qm74	4310	1	Eight	eight	CD
cord-015021-pol2qm74	4310	2	of	of	IN
cord-015021-pol2qm74	4310	3	nine	nine	CD
cord-015021-pol2qm74	4310	4	patients	patient	NNS
cord-015021-pol2qm74	4310	5	with	with	IN
cord-015021-pol2qm74	4310	6	sepsis	sepsis	NN
cord-015021-pol2qm74	4310	7	syndrome	syndrome	NN
cord-015021-pol2qm74	4310	8	had	have	VBD
cord-015021-pol2qm74	4310	9	>	>	$
cord-015021-pol2qm74	4310	10	100	100	CD
cord-015021-pol2qm74	4310	11	%	%	NN
cord-015021-pol2qm74	4310	12	increase	increase	NN
cord-015021-pol2qm74	4310	13	in	in	IN
cord-015021-pol2qm74	4310	14	plasma	plasma	NN
cord-015021-pol2qm74	4310	15	IgE	IgE	NNP
cord-015021-pol2qm74	4310	16	from	from	IN
cord-015021-pol2qm74	4310	17	admission	admission	NN
cord-015021-pol2qm74	4310	18	.	.	.
cord-015021-pol2qm74	4311	1	One	one	CD
cord-015021-pol2qm74	4311	2	patient	patient	NN
cord-015021-pol2qm74	4311	3	's	's	POS
cord-015021-pol2qm74	4311	4	IgE	ige	NN
cord-015021-pol2qm74	4311	5	levels	level	NNS
cord-015021-pol2qm74	4311	6	were	be	VBD
cord-015021-pol2qm74	4311	7	normal	normal	JJ
cord-015021-pol2qm74	4311	8	(	(	-LRB-
cord-015021-pol2qm74	4311	9	20	20	CD
cord-015021-pol2qm74	4311	10	-	-	SYM
cord-015021-pol2qm74	4311	11	100	100	CD
cord-015021-pol2qm74	4311	12	ng	ng	NN
cord-015021-pol2qm74	4311	13	/	/	SYM
cord-015021-pol2qm74	4311	14	ml	ml	NN
cord-015021-pol2qm74	4311	15	)	)	-RRB-
cord-015021-pol2qm74	4311	16	for	for	IN
cord-015021-pol2qm74	4311	17	24	24	CD
cord-015021-pol2qm74	4311	18	days	day	NNS
cord-015021-pol2qm74	4311	19	and	and	CC
cord-015021-pol2qm74	4311	20	then	then	RB
cord-015021-pol2qm74	4311	21	increased	increase	VBD
cord-015021-pol2qm74	4311	22	to	to	IN
cord-015021-pol2qm74	4311	23	7300	7300	CD
cord-015021-pol2qm74	4311	24	ng	ng	NN
cord-015021-pol2qm74	4311	25	/	/	SYM
cord-015021-pol2qm74	4311	26	ml	ml	NN
cord-015021-pol2qm74	4311	27	over	over	IN
cord-015021-pol2qm74	4311	28	the	the	DT
cord-015021-pol2qm74	4311	29	next	next	JJ
cord-015021-pol2qm74	4311	30	12	12	CD
cord-015021-pol2qm74	4311	31	days	day	NNS
cord-015021-pol2qm74	4311	32	,	,	,
cord-015021-pol2qm74	4311	33	after	after	IN
cord-015021-pol2qm74	4311	34	onset	onset	NN
cord-015021-pol2qm74	4311	35	of	of	IN
cord-015021-pol2qm74	4311	36	sepsis	sepsis	NN
cord-015021-pol2qm74	4311	37	syndrome	syndrome	NN
cord-015021-pol2qm74	4311	38	.	.	.
cord-015021-pol2qm74	4312	1	Changes	change	NNS
cord-015021-pol2qm74	4312	2	in	in	IN
cord-015021-pol2qm74	4312	3	IgE	ige	NN
cord-015021-pol2qm74	4312	4	plasma	plasma	NN
cord-015021-pol2qm74	4312	5	levels	level	NNS
cord-015021-pol2qm74	4312	6	may	may	MD
cord-015021-pol2qm74	4312	7	reflect	reflect	VB
cord-015021-pol2qm74	4312	8	the	the	DT
cord-015021-pol2qm74	4312	9	action	action	NN
cord-015021-pol2qm74	4312	10	of	of	IN
cord-015021-pol2qm74	4312	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	4312	12	,	,	,
cord-015021-pol2qm74	4312	13	such	such	JJ
cord-015021-pol2qm74	4312	14	as	as	IN
cord-015021-pol2qm74	4312	15	IL-4	IL-4	NNP
cord-015021-pol2qm74	4312	16	,	,	,
cord-015021-pol2qm74	4312	17	which	which	WDT
cord-015021-pol2qm74	4312	18	concurrently	concurrently	RB
cord-015021-pol2qm74	4312	19	regulate	regulate	VBP
cord-015021-pol2qm74	4312	20	production	production	NN
cord-015021-pol2qm74	4312	21	of	of	IN
cord-015021-pol2qm74	4312	22	IgE	IgE	NNP
cord-015021-pol2qm74	4312	23	and	and	CC
cord-015021-pol2qm74	4312	24	IL-1	IL-1	NNP
cord-015021-pol2qm74	4312	25	receptor	receptor	NN
cord-015021-pol2qm74	4312	26	antagonist	antagonist	NN
cord-015021-pol2qm74	4312	27	in	in	IN
cord-015021-pol2qm74	4312	28	a	a	DT
cord-015021-pol2qm74	4312	29	response	response	NN
cord-015021-pol2qm74	4312	30	to	to	IN
cord-015021-pol2qm74	4312	31	sepsis	sepsis	NN
cord-015021-pol2qm74	4312	32	.	.	.
cord-015021-pol2qm74	4313	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	4313	2	remains	remain	VBZ
cord-015021-pol2qm74	4313	3	a	a	DT
cord-015021-pol2qm74	4313	4	leading	leading	JJ
cord-015021-pol2qm74	4313	5	cause	cause	NN
cord-015021-pol2qm74	4313	6	of	of	IN
cord-015021-pol2qm74	4313	7	late	late	JJ
cord-015021-pol2qm74	4313	8	mortality	mortality	NN
cord-015021-pol2qm74	4313	9	in	in	IN
cord-015021-pol2qm74	4313	10	trauma	trauma	NN
cord-015021-pol2qm74	4313	11	and	and	CC
cord-015021-pol2qm74	4313	12	HS	HS	NNP
cord-015021-pol2qm74	4313	13	.	.	.
cord-015021-pol2qm74	4314	1	Although	although	IN
cord-015021-pol2qm74	4314	2	HS	HS	NNP
cord-015021-pol2qm74	4314	3	-	-	HYPH
cord-015021-pol2qm74	4314	4	induced	induce	VBN
cord-015021-pol2qm74	4314	5	bacterial	bacterial	JJ
cord-015021-pol2qm74	4314	6	translocation	translocation	NN
cord-015021-pol2qm74	4314	7	is	be	VBZ
cord-015021-pol2qm74	4314	8	supposed	suppose	VBN
cord-015021-pol2qm74	4314	9	to	to	TO
cord-015021-pol2qm74	4314	10	be	be	VB
cord-015021-pol2qm74	4314	11	the	the	DT
cord-015021-pol2qm74	4314	12	major	major	JJ
cord-015021-pol2qm74	4314	13	cause	cause	NN
cord-015021-pol2qm74	4314	14	of	of	IN
cord-015021-pol2qm74	4314	15	sepsis	sepsis	NN
cord-015021-pol2qm74	4314	16	and	and	CC
cord-015021-pol2qm74	4314	17	MOF	MOF	NNP
cord-015021-pol2qm74	4314	18	,	,	,
cord-015021-pol2qm74	4314	19	depression	depression	NN
cord-015021-pol2qm74	4314	20	of	of	IN
cord-015021-pol2qm74	4314	21	the	the	DT
cord-015021-pol2qm74	4314	22	RES	res	NN
cord-015021-pol2qm74	4314	23	increases	increase	VBZ
cord-015021-pol2qm74	4314	24	susceptibility	susceptibility	NN
cord-015021-pol2qm74	4314	25	to	to	IN
cord-015021-pol2qm74	4314	26	infection	infection	NN
cord-015021-pol2qm74	4314	27	after	after	IN
cord-015021-pol2qm74	4314	28	injury	injury	NN
cord-015021-pol2qm74	4314	29	.	.	.
cord-015021-pol2qm74	4315	1	The	the	DT
cord-015021-pol2qm74	4315	2	purposes	purpose	NNS
cord-015021-pol2qm74	4315	3	of	of	IN
cord-015021-pol2qm74	4315	4	this	this	DT
cord-015021-pol2qm74	4315	5	study	study	NN
cord-015021-pol2qm74	4315	6	were	be	VBD
cord-015021-pol2qm74	4315	7	:	:	:
cord-015021-pol2qm74	4315	8	a	a	LS
cord-015021-pol2qm74	4315	9	)	)	-RRB-
cord-015021-pol2qm74	4315	10	to	to	TO
cord-015021-pol2qm74	4315	11	evaluate	evaluate	VB
cord-015021-pol2qm74	4315	12	the	the	DT
cord-015021-pol2qm74	4315	13	RES	res	NN
cord-015021-pol2qm74	4315	14	in	in	IN
cord-015021-pol2qm74	4315	15	the	the	DT
cord-015021-pol2qm74	4315	16	lung	lung	NN
cord-015021-pol2qm74	4315	17	,	,	,
cord-015021-pol2qm74	4315	18	spleen	spleen	NN
cord-015021-pol2qm74	4315	19	and	and	CC
cord-015021-pol2qm74	4315	20	liver	liver	NN
cord-015021-pol2qm74	4315	21	after	after	IN
cord-015021-pol2qm74	4315	22	HS	HS	NNP
cord-015021-pol2qm74	4315	23	and	and	CC
cord-015021-pol2qm74	4315	24	subsequent	subsequent	JJ
cord-015021-pol2qm74	4315	25	Hypertonic	Hypertonic	NNP
cord-015021-pol2qm74	4315	26	Saline	Saline	NNP
cord-015021-pol2qm74	4315	27	(	(	-LRB-
cord-015021-pol2qm74	4315	28	HSL	HSL	NNP
cord-015021-pol2qm74	4315	29	)	)	-RRB-
cord-015021-pol2qm74	4315	30	treatment	treatment	NN
cord-015021-pol2qm74	4315	31	,	,	,
cord-015021-pol2qm74	4315	32	and	and	CC
cord-015021-pol2qm74	4315	33	b	b	LS
cord-015021-pol2qm74	4315	34	)	)	-RRB-
cord-015021-pol2qm74	4315	35	to	to	TO
cord-015021-pol2qm74	4315	36	document	document	VB
cord-015021-pol2qm74	4315	37	the	the	DT
cord-015021-pol2qm74	4315	38	patterns	pattern	NNS
cord-015021-pol2qm74	4315	39	of	of	IN
cord-015021-pol2qm74	4315	40	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	4315	41	activity	activity	NN
cord-015021-pol2qm74	4315	42	in	in	IN
cord-015021-pol2qm74	4315	43	these	these	DT
cord-015021-pol2qm74	4315	44	organs	organ	NNS
cord-015021-pol2qm74	4315	45	during	during	IN
cord-015021-pol2qm74	4315	46	24	24	CD
cord-015021-pol2qm74	4315	47	hrs	hrs	NN
cord-015021-pol2qm74	4315	48	.	.	.
cord-015021-pol2qm74	4316	1	Adult	adult	JJ
cord-015021-pol2qm74	4316	2	male	male	JJ
cord-015021-pol2qm74	4316	3	Wistar	Wistar	NNP
cord-015021-pol2qm74	4316	4	rats	rat	NNS
cord-015021-pol2qm74	4316	5	(	(	-LRB-
cord-015021-pol2qm74	4316	6	250+_23	250+_23	CD
cord-015021-pol2qm74	4316	7	gin	gin	NN
cord-015021-pol2qm74	4316	8	)	)	-RRB-
cord-015021-pol2qm74	4316	9	were	be	VBD
cord-015021-pol2qm74	4316	10	submitted	submit	VBN
cord-015021-pol2qm74	4316	11	to	to	IN
cord-015021-pol2qm74	4316	12	HS	HS	NNP
cord-015021-pol2qm74	4316	13	(	(	-LRB-
cord-015021-pol2qm74	4316	14	SBP	SBP	NNP
cord-015021-pol2qm74	4316	15	40	40	CD
cord-015021-pol2qm74	4316	16	tort	tort	NN
cord-015021-pol2qm74	4316	17	)	)	-RRB-
cord-015021-pol2qm74	4316	18	and	and	CC
cord-015021-pol2qm74	4316	19	after	after	IN
cord-015021-pol2qm74	4316	20	t	t	NNP
cord-015021-pol2qm74	4316	21	hr	hr	NNP
cord-015021-pol2qm74	4316	22	(	(	-LRB-
cord-015021-pol2qm74	4316	23	Shock	shock	NN
cord-015021-pol2qm74	4316	24	I	-PRON-	PRP
cord-015021-pol2qm74	4316	25	hr	hr	NN
cord-015021-pol2qm74	4316	26	)	)	-RRB-
cord-015021-pol2qm74	4316	27	and	and	CC
cord-015021-pol2qm74	4316	28	24	24	CD
cord-015021-pol2qm74	4316	29	hrs	hrs	NN
cord-015021-pol2qm74	4316	30	(	(	-LRB-
cord-015021-pol2qm74	4316	31	Shock	shock	NN
cord-015021-pol2qm74	4316	32	24	24	CD
cord-015021-pol2qm74	4316	33	hrs	hrs	NN
cord-015021-pol2qm74	4316	34	)	)	-RRB-
cord-015021-pol2qm74	4316	35	HSL	hsl	NN
cord-015021-pol2qm74	4316	36	(	(	-LRB-
cord-015021-pol2qm74	4316	37	NaC17.5	nac17.5	CD
cord-015021-pol2qm74	4316	38	%	%	NN
cord-015021-pol2qm74	4316	39	,	,	,
cord-015021-pol2qm74	4316	40	3.5	3.5	CD
cord-015021-pol2qm74	4316	41	ml	ml	NN
cord-015021-pol2qm74	4316	42	/	/	SYM
cord-015021-pol2qm74	4316	43	Kg	Kg	NNP
cord-015021-pol2qm74	4316	44	)	)	-RRB-
cord-015021-pol2qm74	4316	45	treatment	treatment	NN
cord-015021-pol2qm74	4316	46	,	,	,
cord-015021-pol2qm74	4316	47	1131	1131	CD
cord-015021-pol2qm74	4316	48	E.	E.	NNP
cord-015021-pol2qm74	4316	49	coli	coli	NNS
cord-015021-pol2qm74	4316	50	(	(	-LRB-
cord-015021-pol2qm74	4316	51	I	i	NN
cord-015021-pol2qm74	4316	52	131	131	CD
cord-015021-pol2qm74	4316	53	)	)	-RRB-
cord-015021-pol2qm74	4316	54	was	be	VBD
cord-015021-pol2qm74	4316	55	injected	inject	VBN
cord-015021-pol2qm74	4316	56	into	into	IN
cord-015021-pol2qm74	4316	57	the	the	DT
cord-015021-pol2qm74	4316	58	portal	portal	JJ
cord-015021-pol2qm74	4316	59	vein	vein	NN
cord-015021-pol2qm74	4316	60	10	10	CD
cord-015021-pol2qm74	4316	61	~tCi	~tCi	NFP
cord-015021-pol2qm74	4316	62	(	(	-LRB-
cord-015021-pol2qm74	4316	63	n_>12	n_>12	CD
cord-015021-pol2qm74	4316	64	)	)	-RRB-
cord-015021-pol2qm74	4316	65	.	.	.
cord-015021-pol2qm74	4317	1	Twenty	twenty	CD
cord-015021-pol2qm74	4317	2	minutes	minute	NNS
cord-015021-pol2qm74	4317	3	later	later	RB
cord-015021-pol2qm74	4317	4	,	,	,
cord-015021-pol2qm74	4317	5	the	the	DT
cord-015021-pol2qm74	4317	6	lungs	lung	NNS
cord-015021-pol2qm74	4317	7	,	,	,
cord-015021-pol2qm74	4317	8	spleen	spleen	NN
cord-015021-pol2qm74	4317	9	and	and	CC
cord-015021-pol2qm74	4317	10	liver	liver	NN
cord-015021-pol2qm74	4317	11	were	be	VBD
cord-015021-pol2qm74	4317	12	harvested	harvest	VBN
cord-015021-pol2qm74	4317	13	and	and	CC
cord-015021-pol2qm74	4317	14	scintilographic	scintilographic	JJ
cord-015021-pol2qm74	4317	15	counts	count	NNS
cord-015021-pol2qm74	4317	16	obtained	obtain	VBN
cord-015021-pol2qm74	4317	17	.	.	.
cord-015021-pol2qm74	4318	1	Data	Data	NNP
cord-015021-pol2qm74	4318	2	is	be	VBZ
cord-015021-pol2qm74	4318	3	depicted	depict	VBN
cord-015021-pol2qm74	4318	4	as	as	IN
cord-015021-pol2qm74	4318	5	mean_%+SEM	mean_%+SEM	NNP
cord-015021-pol2qm74	4318	6	*	*	NFP
cord-015021-pol2qm74	4318	7	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	4318	8	,	,	,
cord-015021-pol2qm74	4318	9	~	~	NFP
cord-015021-pol2qm74	4318	10	"	"	``
cord-015021-pol2qm74	4318	11	p<0.001	p<0.001	JJ
cord-015021-pol2qm74	4318	12	and	and	CC
cord-015021-pol2qm74	4318	13	statistical	statistical	JJ
cord-015021-pol2qm74	4318	14	analysis	analysis	NN
cord-015021-pol2qm74	4318	15	was	be	VBD
cord-015021-pol2qm74	4318	16	performed	perform	VBN
cord-015021-pol2qm74	4318	17	by	by	IN
cord-015021-pol2qm74	4318	18	Analysis	Analysis	NNP
cord-015021-pol2qm74	4318	19	of	of	IN
cord-015021-pol2qm74	4318	20	Variance	Variance	NNP
cord-015021-pol2qm74	4318	21	and	and	CC
cord-015021-pol2qm74	4318	22	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	4318	23	tests	test	NNS
cord-015021-pol2qm74	4318	24	.	.	.
cord-015021-pol2qm74	4319	1	One	one	CD
cord-015021-pol2qm74	4319	2	hr	hr	NN
cord-015021-pol2qm74	4319	3	after	after	IN
cord-015021-pol2qm74	4319	4	treatment	treatment	NN
cord-015021-pol2qm74	4319	5	,	,	,
cord-015021-pol2qm74	4319	6	lung	lung	NN
cord-015021-pol2qm74	4319	7	1131	1131	CD
cord-015021-pol2qm74	4319	8	uptake	uptake	NN
cord-015021-pol2qm74	4319	9	was	be	VBD
cord-015021-pol2qm74	4319	10	increased	increase	VBN
cord-015021-pol2qm74	4319	11	and	and	CC
cord-015021-pol2qm74	4319	12	liver	liver	NN
cord-015021-pol2qm74	4319	13	and	and	CC
cord-015021-pol2qm74	4319	14	spleen	spleen	NN
cord-015021-pol2qm74	4319	15	1131	1131	CD
cord-015021-pol2qm74	4320	1	uptake	uptake	NN
cord-015021-pol2qm74	4320	2	were	be	VBD
cord-015021-pol2qm74	4320	3	reduced	reduce	VBN
cord-015021-pol2qm74	4320	4	compared	compare	VBN
cord-015021-pol2qm74	4320	5	to	to	IN
cord-015021-pol2qm74	4320	6	sham	sham	NN
cord-015021-pol2qm74	4320	7	.	.	.
cord-015021-pol2qm74	4321	1	Twenty	twenty	CD
cord-015021-pol2qm74	4321	2	four	four	CD
cord-015021-pol2qm74	4321	3	hrs	hrs	NN
cord-015021-pol2qm74	4321	4	after	after	IN
cord-015021-pol2qm74	4321	5	treatment	treatment	NN
cord-015021-pol2qm74	4321	6	,	,	,
cord-015021-pol2qm74	4321	7	all	all	DT
cord-015021-pol2qm74	4321	8	organs	organ	NNS
cord-015021-pol2qm74	4321	9	,	,	,
cord-015021-pol2qm74	4321	10	except	except	IN
cord-015021-pol2qm74	4321	11	lung	lung	NN
cord-015021-pol2qm74	4321	12	uptake	uptake	NN
cord-015021-pol2qm74	4321	13	,	,	,
cord-015021-pol2qm74	4321	14	returned	return	VBD
cord-015021-pol2qm74	4321	15	to	to	IN
cord-015021-pol2qm74	4321	16	normal	normal	JJ
cord-015021-pol2qm74	4321	17	values	value	NNS
cord-015021-pol2qm74	4321	18	.	.	.
cord-015021-pol2qm74	4322	1	Radioautographic	radioautographic	JJ
cord-015021-pol2qm74	4322	2	histological	histological	JJ
cord-015021-pol2qm74	4322	3	analysis	analysis	NN
cord-015021-pol2qm74	4322	4	revealed	reveal	VBD
cord-015021-pol2qm74	4322	5	radiolabeled	radiolabele	VBN
cord-015021-pol2qm74	4322	6	particles	particle	NNS
cord-015021-pol2qm74	4322	7	inside	inside	IN
cord-015021-pol2qm74	4322	8	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	4322	9	cells	cell	NNS
cord-015021-pol2qm74	4322	10	of	of	IN
cord-015021-pol2qm74	4322	11	all	all	DT
cord-015021-pol2qm74	4322	12	organs	organ	NNS
cord-015021-pol2qm74	4322	13	.	.	.
cord-015021-pol2qm74	4323	1	We	-PRON-	PRP
cord-015021-pol2qm74	4323	2	conclude	conclude	VBP
cord-015021-pol2qm74	4323	3	that	that	IN
cord-015021-pol2qm74	4323	4	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4323	5	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	4323	6	activity	activity	NN
cord-015021-pol2qm74	4323	7	increases	increase	NNS
cord-015021-pol2qm74	4323	8	after	after	IN
cord-015021-pol2qm74	4323	9	1	1	CD
cord-015021-pol2qm74	4323	10	hr	hr	NN
cord-015021-pol2qm74	4323	11	of	of	IN
cord-015021-pol2qm74	4323	12	HS	HS	NNP
cord-015021-pol2qm74	4323	13	HSL	HSL	NNP
cord-015021-pol2qm74	4323	14	reatment	reatment	NN
cord-015021-pol2qm74	4323	15	,	,	,
cord-015021-pol2qm74	4323	16	diminishing	diminish	VBG
cord-015021-pol2qm74	4323	17	by	by	IN
cord-015021-pol2qm74	4323	18	24	24	CD
cord-015021-pol2qm74	4323	19	hrs	hrs	NN
cord-015021-pol2qm74	4323	20	although	although	IN
cord-015021-pol2qm74	4323	21	still	still	RB
cord-015021-pol2qm74	4323	22	above	above	IN
cord-015021-pol2qm74	4323	23	normal	normal	JJ
cord-015021-pol2qm74	4323	24	values	value	NNS
cord-015021-pol2qm74	4323	25	.	.	.
cord-015021-pol2qm74	4324	1	In	in	IN
cord-015021-pol2qm74	4324	2	contrast	contrast	NN
cord-015021-pol2qm74	4324	3	,	,	,
cord-015021-pol2qm74	4324	4	RES	res	NN
cord-015021-pol2qm74	4324	5	suppression	suppression	NN
cord-015021-pol2qm74	4324	6	occurs	occur	VBZ
cord-015021-pol2qm74	4324	7	in	in	IN
cord-015021-pol2qm74	4324	8	liver	liver	NN
cord-015021-pol2qm74	4324	9	and	and	CC
cord-015021-pol2qm74	4324	10	spleen	spleen	NNS
cord-015021-pol2qm74	4324	11	after	after	IN
cord-015021-pol2qm74	4324	12	1	1	CD
cord-015021-pol2qm74	4324	13	hr	hr	NN
cord-015021-pol2qm74	4324	14	HS	HS	NNP
cord-015021-pol2qm74	4324	15	HSL	HSL	NNP
cord-015021-pol2qm74	4324	16	treatment	treatment	NN
cord-015021-pol2qm74	4324	17	,	,	,
cord-015021-pol2qm74	4324	18	returning	return	VBG
cord-015021-pol2qm74	4324	19	to	to	IN
cord-015021-pol2qm74	4324	20	normal	normal	JJ
cord-015021-pol2qm74	4324	21	values	value	NNS
cord-015021-pol2qm74	4324	22	by	by	IN
cord-015021-pol2qm74	4324	23	24	24	CD
cord-015021-pol2qm74	4324	24	hrs	hrs	NN
cord-015021-pol2qm74	4324	25	.	.	.
cord-015021-pol2qm74	4325	1	These	these	DT
cord-015021-pol2qm74	4325	2	results	result	NNS
cord-015021-pol2qm74	4325	3	may	may	MD
cord-015021-pol2qm74	4325	4	explain	explain	VB
cord-015021-pol2qm74	4325	5	lung	lung	NN
cord-015021-pol2qm74	4325	6	complications	complication	NNS
cord-015021-pol2qm74	4325	7	and	and	CC
cord-015021-pol2qm74	4325	8	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	4325	9	after	after	IN
cord-015021-pol2qm74	4325	10	trauma	trauma	NN
cord-015021-pol2qm74	4325	11	.	.	.
cord-015021-pol2qm74	4326	1	Infusion	infusion	NN
cord-015021-pol2qm74	4326	2	of	of	IN
cord-015021-pol2qm74	4326	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4326	4	as	as	RB
cord-015021-pol2qm74	4326	5	well	well	RB
cord-015021-pol2qm74	4326	6	as	as	IN
cord-015021-pol2qm74	4326	7	major	major	JJ
cord-015021-pol2qm74	4326	8	surgery	surgery	NN
cord-015021-pol2qm74	4326	9	is	be	VBZ
cord-015021-pol2qm74	4326	10	followed	follow	VBN
cord-015021-pol2qm74	4326	11	by	by	IN
cord-015021-pol2qm74	4326	12	lymphopenia	lymphopenia	NNP
cord-015021-pol2qm74	4326	13	in	in	IN
cord-015021-pol2qm74	4326	14	peripheral	peripheral	JJ
cord-015021-pol2qm74	4326	15	blood	blood	NN
cord-015021-pol2qm74	4326	16	.	.	.
cord-015021-pol2qm74	4327	1	The	the	DT
cord-015021-pol2qm74	4327	2	purpose	purpose	NN
cord-015021-pol2qm74	4327	3	of	of	IN
cord-015021-pol2qm74	4327	4	this	this	DT
cord-015021-pol2qm74	4327	5	study	study	NN
cord-015021-pol2qm74	4327	6	was	be	VBD
cord-015021-pol2qm74	4327	7	to	to	TO
cord-015021-pol2qm74	4327	8	investigate	investigate	VB
cord-015021-pol2qm74	4327	9	to	to	TO
cord-015021-pol2qm74	4327	10	which	which	WDT
cord-015021-pol2qm74	4327	11	tissues	tissue	VBZ
cord-015021-pol2qm74	4327	12	the	the	DT
cord-015021-pol2qm74	4327	13	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4327	14	are	be	VBP
cord-015021-pol2qm74	4327	15	redistributed	redistribute	VBN
cord-015021-pol2qm74	4327	16	in	in	IN
cord-015021-pol2qm74	4327	17	response	response	NN
cord-015021-pol2qm74	4327	18	to	to	IN
cord-015021-pol2qm74	4327	19	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	4327	20	and	and	CC
cord-015021-pol2qm74	4327	21	major	major	JJ
cord-015021-pol2qm74	4327	22	surgery	surgery	NN
cord-015021-pol2qm74	4327	23	.	.	.
cord-015021-pol2qm74	4328	1	In	in	IN
cord-015021-pol2qm74	4328	2	addition	addition	NN
cord-015021-pol2qm74	4328	3	changes	change	NNS
cord-015021-pol2qm74	4328	4	in	in	IN
cord-015021-pol2qm74	4328	5	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4328	6	subpopulations	subpopulation	NNS
cord-015021-pol2qm74	4328	7	and	and	CC
cord-015021-pol2qm74	4328	8	expression	expression	NN
cord-015021-pol2qm74	4328	9	of	of	IN
cord-015021-pol2qm74	4328	10	MECII	MECII	NNP
cord-015021-pol2qm74	4328	11	was	be	VBD
cord-015021-pol2qm74	4328	12	measured	measure	VBN
cord-015021-pol2qm74	4328	13	.	.	.
cord-015021-pol2qm74	4329	1	Lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4329	2	were	be	VBD
cord-015021-pol2qm74	4329	3	isolated	isolate	VBN
cord-015021-pol2qm74	4329	4	from	from	IN
cord-015021-pol2qm74	4329	5	peripheral	peripheral	JJ
cord-015021-pol2qm74	4329	6	blood	blood	NN
cord-015021-pol2qm74	4329	7	of	of	IN
cord-015021-pol2qm74	4329	8	30	30	CD
cord-015021-pol2qm74	4329	9	rabbits	rabbit	NNS
cord-015021-pol2qm74	4329	10	,	,	,
cord-015021-pol2qm74	4329	11	labelled	label	VBN
cord-015021-pol2qm74	4329	12	with	with	IN
cord-015021-pol2qm74	4329	13	111Indium	111indium	CD
cord-015021-pol2qm74	4329	14	-	-	HYPH
cord-015021-pol2qm74	4329	15	tropolene	tropolene	NN
cord-015021-pol2qm74	4329	16	and	and	CC
cord-015021-pol2qm74	4329	17	reinjected	reinjecte	VBD
cord-015021-pol2qm74	4329	18	intravenously	intravenously	RB
cord-015021-pol2qm74	4329	19	into	into	IN
cord-015021-pol2qm74	4329	20	the	the	DT
cord-015021-pol2qm74	4329	21	rabbits	rabbit	NNS
cord-015021-pol2qm74	4329	22	,	,	,
cord-015021-pol2qm74	4329	23	i0	i0	NN
cord-015021-pol2qm74	4329	24	rabbits	rabbit	NNS
cord-015021-pol2qm74	4329	25	received	receive	VBD
cord-015021-pol2qm74	4329	26	an	an	DT
cord-015021-pol2qm74	4329	27	infusion	infusion	NN
cord-015021-pol2qm74	4329	28	of	of	IN
cord-015021-pol2qm74	4329	29	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	4329	30	coli	coli	NNS
cord-015021-pol2qm74	4329	31	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4329	32	2	2	CD
cord-015021-pol2qm74	4330	1	~g	~g	NNP
cord-015021-pol2qm74	4330	2	/	/	SYM
cord-015021-pol2qm74	4330	3	kg	kg	NNS
cord-015021-pol2qm74	4330	4	,	,	,
cord-015021-pol2qm74	4330	5	while	while	IN
cord-015021-pol2qm74	4330	6	i0	i0	NN
cord-015021-pol2qm74	4330	7	rabbits	rabbit	NNS
cord-015021-pol2qm74	4330	8	were	be	VBD
cord-015021-pol2qm74	4330	9	subjected	subject	VBN
cord-015021-pol2qm74	4330	10	to	to	IN
cord-015021-pol2qm74	4330	11	a	a	DT
cord-015021-pol2qm74	4330	12	major	major	JJ
cord-015021-pol2qm74	4330	13	sham	sham	JJ
cord-015021-pol2qm74	4330	14	operation	operation	NN
cord-015021-pol2qm74	4330	15	and	and	CC
cord-015021-pol2qm74	4330	16	i0	i0	NN
cord-015021-pol2qm74	4330	17	rabbits	rabbit	NNS
cord-015021-pol2qm74	4330	18	served	serve	VBD
cord-015021-pol2qm74	4330	19	as	as	IN
cord-015021-pol2qm74	4330	20	a	a	DT
cord-015021-pol2qm74	4330	21	control	control	NN
cord-015021-pol2qm74	4330	22	group	group	NN
cord-015021-pol2qm74	4330	23	.	.	.
cord-015021-pol2qm74	4331	1	The	the	DT
cord-015021-pol2qm74	4331	2	redistribution	redistribution	NN
cord-015021-pol2qm74	4331	3	of	of	IN
cord-015021-pol2qm74	4331	4	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4331	5	were	be	VBD
cord-015021-pol2qm74	4331	6	imaged	image	VBN
cord-015021-pol2qm74	4331	7	with	with	IN
cord-015021-pol2qm74	4331	8	af	af	NNP
cord-015021-pol2qm74	4331	9	gamma	gamma	NN
cord-015021-pol2qm74	4331	10	camera	camera	NN
cord-015021-pol2qm74	4331	11	,	,	,
cord-015021-pol2qm74	4331	12	and	and	CC
cord-015021-pol2qm74	4331	13	calculated	calculate	VBN
cord-015021-pol2qm74	4331	14	with	with	IN
cord-015021-pol2qm74	4331	15	an	an	DT
cord-015021-pol2qm74	4331	16	interfaces	interface	NNS
cord-015021-pol2qm74	4331	17	computer	computer	NN
cord-015021-pol2qm74	4331	18	before	before	RB
cord-015021-pol2qm74	4331	19	,	,	,
cord-015021-pol2qm74	4331	20	and	and	CC
cord-015021-pol2qm74	4331	21	2	2	CD
cord-015021-pol2qm74	4331	22	,	,	,
cord-015021-pol2qm74	4331	23	4	4	CD
cord-015021-pol2qm74	4331	24	and	and	CC
cord-015021-pol2qm74	4331	25	6	6	CD
cord-015021-pol2qm74	4331	26	hours	hour	NNS
cord-015021-pol2qm74	4331	27	after	after	IN
cord-015021-pol2qm74	4331	28	major	major	JJ
cord-015021-pol2qm74	4331	29	surgery	surgery	NN
cord-015021-pol2qm74	4331	30	or	or	CC
cord-015021-pol2qm74	4331	31	infusion	infusion	NN
cord-015021-pol2qm74	4331	32	of	of	IN
cord-015021-pol2qm74	4331	33	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4331	34	or	or	CC
cord-015021-pol2qm74	4331	35	saline	saline	NN
cord-015021-pol2qm74	4331	36	.	.	.
cord-015021-pol2qm74	4332	1	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	4332	2	-	-	HYPH
cord-015021-pol2qm74	4332	3	l~	l~	XX
cord-015021-pol2qm74	4332	4	and	and	CC
cord-015021-pol2qm74	4332	5	serum	serum	NN
cord-015021-pol2qm74	4332	6	cortisol	cortisol	NN
cord-015021-pol2qm74	4332	7	were	be	VBD
cord-015021-pol2qm74	4332	8	measured	measure	VBN
cord-015021-pol2qm74	4332	9	.	.	.
cord-015021-pol2qm74	4333	1	In	in	IN
cord-015021-pol2qm74	4333	2	addition	addition	NN
cord-015021-pol2qm74	4333	3	we	-PRON-	PRP
cord-015021-pol2qm74	4333	4	followed	follow	VBD
cord-015021-pol2qm74	4333	5	CD2	CD2	NNP
cord-015021-pol2qm74	4333	6	,	,	,
cord-015021-pol2qm74	4333	7	CD3	CD3	NNP
cord-015021-pol2qm74	4333	8	,	,	,
cord-015021-pol2qm74	4333	9	CDlla	CDlla	NNP
cord-015021-pol2qm74	4333	10	/	/	SYM
cord-015021-pol2qm74	4333	11	b	b	NN
cord-015021-pol2qm74	4333	12	,	,	,
cord-015021-pol2qm74	4333	13	CDIS	CDIS	NNP
cord-015021-pol2qm74	4333	14	,	,	,
cord-015021-pol2qm74	4333	15	CD20	CD20	NNP
cord-015021-pol2qm74	4333	16	,	,	,
cord-015021-pol2qm74	4333	17	CD44	CD44	NNP
cord-015021-pol2qm74	4333	18	,	,	,
cord-015021-pol2qm74	4333	19	MHCII	MHCII	NNP
cord-015021-pol2qm74	4333	20	and	and	CC
cord-015021-pol2qm74	4333	21	CD4	CD4	NNP
cord-015021-pol2qm74	4333	22	/	/	SYM
cord-015021-pol2qm74	4333	23	CD8	CD8	NNP
cord-015021-pol2qm74	4333	24	ratio	ratio	NN
cord-015021-pol2qm74	4333	25	.	.	.
cord-015021-pol2qm74	4334	1	Following	follow	VBG
cord-015021-pol2qm74	4334	2	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	4334	3	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	4334	4	-	-	HYPH
cord-015021-pol2qm74	4334	5	lf~	lf~	NN
cord-015021-pol2qm74	4334	6	increased	increase	VBD
cord-015021-pol2qm74	4334	7	significantly	significantly	RB
cord-015021-pol2qm74	4334	8	,	,	,
cord-015021-pol2qm74	4334	9	following	follow	VBG
cord-015021-pol2qm74	4334	10	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	4334	11	as	as	RB
cord-015021-pol2qm74	4334	12	well	well	RB
cord-015021-pol2qm74	4334	13	as	as	IN
cord-015021-pol2qm74	4334	14	major	major	JJ
cord-015021-pol2qm74	4334	15	surgery	surgery	NN
cord-015021-pol2qm74	4334	16	serum	serum	NN
cord-015021-pol2qm74	4334	17	cortisol	cortisol	NN
cord-015021-pol2qm74	4334	18	increased	increase	VBD
cord-015021-pol2qm74	4334	19	significantly	significantly	RB
cord-015021-pol2qm74	4334	20	.	.	.
cord-015021-pol2qm74	4335	1	Following	follow	VBG
cord-015021-pol2qm74	4335	2	major	major	JJ
cord-015021-pol2qm74	4335	3	surgery	surgery	NN
cord-015021-pol2qm74	4335	4	as	as	RB
cord-015021-pol2qm74	4335	5	well	well	RB
cord-015021-pol2qm74	4335	6	as	as	IN
cord-015021-pol2qm74	4335	7	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	4335	8	there	there	EX
cord-015021-pol2qm74	4335	9	was	be	VBD
cord-015021-pol2qm74	4335	10	significant	significant	JJ
cord-015021-pol2qm74	4335	11	lomphocytepenia	lomphocytepenia	NN
cord-015021-pol2qm74	4335	12	in	in	IN
cord-015021-pol2qm74	4335	13	peripheral	peripheral	JJ
cord-015021-pol2qm74	4335	14	blood	blood	NN
cord-015021-pol2qm74	4335	15	with	with	IN
cord-015021-pol2qm74	4335	16	a	a	DT
cord-015021-pol2qm74	4335	17	decreased	decreased	JJ
cord-015021-pol2qm74	4335	18	CD4	CD4	NNP
cord-015021-pol2qm74	4335	19	/	/	SYM
cord-015021-pol2qm74	4335	20	CD8	CD8	NNP
cord-015021-pol2qm74	4335	21	ratio	ratio	NN
cord-015021-pol2qm74	4335	22	while	while	IN
cord-015021-pol2qm74	4335	23	the	the	DT
cord-015021-pol2qm74	4335	24	CD3	CD3	NNP
cord-015021-pol2qm74	4335	25	positive	positive	JJ
cord-015021-pol2qm74	4335	26	subpopulation	subpopulation	NN
cord-015021-pol2qm74	4335	27	increased	increase	VBD
cord-015021-pol2qm74	4335	28	.	.	.
cord-015021-pol2qm74	4336	1	In	in	IN
cord-015021-pol2qm74	4336	2	addition	addition	NN
cord-015021-pol2qm74	4336	3	there	there	EX
cord-015021-pol2qm74	4336	4	was	be	VBD
cord-015021-pol2qm74	4336	5	a	a	DT
cord-015021-pol2qm74	4336	6	decrease	decrease	NN
cord-015021-pol2qm74	4336	7	in	in	IN
cord-015021-pol2qm74	4336	8	the	the	DT
cord-015021-pol2qm74	4336	9	expression	expression	NN
cord-015021-pol2qm74	4336	10	of	of	IN
cord-015021-pol2qm74	4336	11	MHCII	MHCII	NNP
cord-015021-pol2qm74	4336	12	on	on	IN
cord-015021-pol2qm74	4336	13	the	the	DT
cord-015021-pol2qm74	4336	14	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4336	15	peripheral	peripheral	JJ
cord-015021-pol2qm74	4336	16	blood	blood	NN
cord-015021-pol2qm74	4336	17	.	.	.
cord-015021-pol2qm74	4337	1	The	the	DT
cord-015021-pol2qm74	4337	2	radioactivity	radioactivity	NN
cord-015021-pol2qm74	4337	3	of	of	IN
cord-015021-pol2qm74	4337	4	the	the	DT
cord-015021-pol2qm74	4337	5	lymphatic	lymphatic	JJ
cord-015021-pol2qm74	4337	6	tissue	tissue	NN
cord-015021-pol2qm74	4337	7	in	in	IN
cord-015021-pol2qm74	4337	8	and	and	CC
cord-015021-pol2qm74	4337	9	around	around	IN
cord-015021-pol2qm74	4337	10	the	the	DT
cord-015021-pol2qm74	4337	11	intestine	intestine	NN
cord-015021-pol2qm74	4337	12	increased	increase	VBD
cord-015021-pol2qm74	4337	13	to	to	IN
cord-015021-pol2qm74	4337	14	129	129	CD
cord-015021-pol2qm74	4337	15	%	%	NN
cord-015021-pol2qm74	4337	16	of	of	IN
cord-015021-pol2qm74	4337	17	initial	initial	JJ
cord-015021-pol2qm74	4337	18	values	value	NNS
cord-015021-pol2qm74	4337	19	following	follow	VBG
cord-015021-pol2qm74	4337	20	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	4337	21	and	and	CC
cord-015021-pol2qm74	4337	22	to	to	IN
cord-015021-pol2qm74	4337	23	125	125	CD
cord-015021-pol2qm74	4337	24	%	%	NN
cord-015021-pol2qm74	4337	25	following	follow	VBG
cord-015021-pol2qm74	4337	26	major	major	JJ
cord-015021-pol2qm74	4337	27	surgery	surgery	NN
cord-015021-pol2qm74	4337	28	.	.	.
cord-015021-pol2qm74	4338	1	The	the	DT
cord-015021-pol2qm74	4338	2	results	result	NNS
cord-015021-pol2qm74	4338	3	indicate	indicate	VBP
cord-015021-pol2qm74	4338	4	that	that	IN
cord-015021-pol2qm74	4338	5	endotoxaemia	endotoxaemia	NN
cord-015021-pol2qm74	4338	6	as	as	RB
cord-015021-pol2qm74	4338	7	well	well	RB
cord-015021-pol2qm74	4338	8	as	as	IN
cord-015021-pol2qm74	4338	9	major	major	JJ
cord-015021-pol2qm74	4338	10	surgery	surgery	NN
cord-015021-pol2qm74	4338	11	induces	induce	VBZ
cord-015021-pol2qm74	4338	12	redistribution	redistribution	NN
cord-015021-pol2qm74	4338	13	of	of	IN
cord-015021-pol2qm74	4338	14	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4338	15	from	from	IN
cord-015021-pol2qm74	4338	16	peripheral	peripheral	JJ
cord-015021-pol2qm74	4338	17	blood	blood	NN
cord-015021-pol2qm74	4338	18	to	to	IN
cord-015021-pol2qm74	4338	19	lymphatic	lymphatic	JJ
cord-015021-pol2qm74	4338	20	tissue	tissue	NN
cord-015021-pol2qm74	4338	21	.	.	.
cord-015021-pol2qm74	4339	1	Among	among	IN
cord-015021-pol2qm74	4339	2	the	the	DT
cord-015021-pol2qm74	4339	3	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4339	4	staying	stay	VBG
cord-015021-pol2qm74	4339	5	in	in	IN
cord-015021-pol2qm74	4339	6	peripheral	peripheral	JJ
cord-015021-pol2qm74	4339	7	blood	blood	NN
cord-015021-pol2qm74	4339	8	there	there	EX
cord-015021-pol2qm74	4339	9	was	be	VBD
cord-015021-pol2qm74	4339	10	a	a	DT
cord-015021-pol2qm74	4339	11	decreased	decreased	JJ
cord-015021-pol2qm74	4339	12	expression	expression	NN
cord-015021-pol2qm74	4339	13	of	of	IN
cord-015021-pol2qm74	4339	14	MHCII	MHCII	NNP
cord-015021-pol2qm74	4339	15	and	and	CC
cord-015021-pol2qm74	4339	16	a	a	DT
cord-015021-pol2qm74	4339	17	relative	relative	JJ
cord-015021-pol2qm74	4339	18	decrease	decrease	NN
cord-015021-pol2qm74	4339	19	in	in	IN
cord-015021-pol2qm74	4339	20	CD4	CD4	NNP
cord-015021-pol2qm74	4339	21	cells	cell	NNS
cord-015021-pol2qm74	4339	22	compared	compare	VBN
cord-015021-pol2qm74	4339	23	to	to	IN
cord-015021-pol2qm74	4339	24	CD8	CD8	NNP
cord-015021-pol2qm74	4339	25	positive	positive	JJ
cord-015021-pol2qm74	4339	26	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4339	27	.	.	.
cord-015021-pol2qm74	4340	1	In	in	IN
cord-015021-pol2qm74	4340	2	order	order	NN
cord-015021-pol2qm74	4340	3	to	to	TO
cord-015021-pol2qm74	4340	4	analyze	analyze	VB
cord-015021-pol2qm74	4340	5	the	the	DT
cord-015021-pol2qm74	4340	6	effects	effect	NNS
cord-015021-pol2qm74	4340	7	of	of	IN
cord-015021-pol2qm74	4340	8	immune	immune	JJ
cord-015021-pol2qm74	4340	9	suppressive	suppressive	JJ
cord-015021-pol2qm74	4340	10	substances	substance	NNS
cord-015021-pol2qm74	4340	11	on	on	IN
cord-015021-pol2qm74	4340	12	expression	expression	NN
cord-015021-pol2qm74	4340	13	of	of	IN
cord-015021-pol2qm74	4340	14	mRNA	mrna	NN
cord-015021-pol2qm74	4340	15	of	of	IN
cord-015021-pol2qm74	4340	16	interleukin-2(IL-2	interleukin-2(IL-2	NNP
cord-015021-pol2qm74	4340	17	)	)	-RRB-
cord-015021-pol2qm74	4340	18	and	and	CC
cord-015021-pol2qm74	4340	19	interleukin-2	interleukin-2	IN
cord-015021-pol2qm74	4340	20	reeeptor(IL-2R	reeeptor(IL-2R	NNP
cord-015021-pol2qm74	4340	21	)	)	-RRB-
cord-015021-pol2qm74	4340	22	,	,	,
cord-015021-pol2qm74	4340	23	this	this	DT
cord-015021-pol2qm74	4340	24	study	study	NN
cord-015021-pol2qm74	4340	25	was	be	VBD
cord-015021-pol2qm74	4340	26	carried	carry	VBN
cord-015021-pol2qm74	4340	27	out	out	RP
cord-015021-pol2qm74	4340	28	.	.	.
cord-015021-pol2qm74	4341	1	Twenty	twenty	CD
cord-015021-pol2qm74	4341	2	male	male	JJ
cord-015021-pol2qm74	4341	3	rabbits	rabbit	NNS
cord-015021-pol2qm74	4341	4	with	with	IN
cord-015021-pol2qm74	4341	5	comminuted	comminuted	JJ
cord-015021-pol2qm74	4341	6	fracture	fracture	NN
cord-015021-pol2qm74	4341	7	were	be	VBD
cord-015021-pol2qm74	4341	8	used	use	VBN
cord-015021-pol2qm74	4341	9	in	in	IN
cord-015021-pol2qm74	4341	10	the	the	DT
cord-015021-pol2qm74	4341	11	study	study	NN
cord-015021-pol2qm74	4341	12	.	.	.
cord-015021-pol2qm74	4342	1	Ten	ten	CD
cord-015021-pol2qm74	4342	2	ml	ml	NN
cord-015021-pol2qm74	4342	3	blood	blood	NN
cord-015021-pol2qm74	4342	4	were	be	VBD
cord-015021-pol2qm74	4342	5	taken	take	VBN
cord-015021-pol2qm74	4342	6	at	at	IN
cord-015021-pol2qm74	4342	7	0	0	CD
cord-015021-pol2qm74	4342	8	,	,	,
cord-015021-pol2qm74	4342	9	i	i	PRP
cord-015021-pol2qm74	4342	10	,	,	,
cord-015021-pol2qm74	4342	11	2	2	CD
cord-015021-pol2qm74	4342	12	,	,	,
cord-015021-pol2qm74	4342	13	4	4	CD
cord-015021-pol2qm74	4342	14	,	,	,
cord-015021-pol2qm74	4342	15	6	6	CD
cord-015021-pol2qm74	4342	16	days	day	NNS
cord-015021-pol2qm74	4342	17	after	after	IN
cord-015021-pol2qm74	4342	18	injury	injury	NN
cord-015021-pol2qm74	4342	19	.	.	.
cord-015021-pol2qm74	4343	1	The	the	DT
cord-015021-pol2qm74	4343	2	sera	sera	NNP
cord-015021-pol2qm74	4343	3	were	be	VBD
cord-015021-pol2qm74	4343	4	tested	test	VBN
cord-015021-pol2qm74	4343	5	for	for	IN
cord-015021-pol2qm74	4343	6	the	the	DT
cord-015021-pol2qm74	4343	7	effects	effect	NNS
cord-015021-pol2qm74	4343	8	on	on	IN
cord-015021-pol2qm74	4343	9	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4343	10	blastogenesis	blastogenesis	NN
cord-015021-pol2qm74	4343	11	and	and	CC
cord-015021-pol2qm74	4343	12	induction	induction	NN
cord-015021-pol2qm74	4343	13	of	of	IN
cord-015021-pol2qm74	4343	14	IL-2	il-2	NN
cord-015021-pol2qm74	4343	15	stimulated	stimulate	VBN
cord-015021-pol2qm74	4343	16	by	by	IN
cord-015021-pol2qm74	4343	17	concanavalin	concanavalin	NNP
cord-015021-pol2qm74	4343	18	A(Con	A(Con	NNP
cord-015021-pol2qm74	4343	19	A	A	NNP
cord-015021-pol2qm74	4343	20	)	)	-RRB-
cord-015021-pol2qm74	4343	21	:	:	:
cord-015021-pol2qm74	4344	1	The	the	DT
cord-015021-pol2qm74	4344	2	sera	sera	NNP
cord-015021-pol2qm74	4344	3	from	from	IN
cord-015021-pol2qm74	4344	4	the	the	DT
cord-015021-pol2qm74	4344	5	rabbits	rabbit	NNS
cord-015021-pol2qm74	4345	1	2	2	CD
cord-015021-pol2qm74	4345	2	days	day	NNS
cord-015021-pol2qm74	4345	3	after	after	IN
cord-015021-pol2qm74	4345	4	injury	injury	NN
cord-015021-pol2qm74	4345	5	were	be	VBD
cord-015021-pol2qm74	4345	6	analyzed	analyze	VBN
cord-015021-pol2qm74	4345	7	with	with	IN
cord-015021-pol2qm74	4345	8	SDS	SDS	NNP
cord-015021-pol2qm74	4345	9	-	-	HYPH
cord-015021-pol2qm74	4345	10	PAGE	page	NN
cord-015021-pol2qm74	4345	11	gel	gel	NN
cord-015021-pol2qm74	4345	12	eleetrophoresis	eleetrophoresis	NN
cord-015021-pol2qm74	4345	13	,	,	,
cord-015021-pol2qm74	4345	14	and	and	CC
cord-015021-pol2qm74	4345	15	divided	divide	VBD
cord-015021-pol2qm74	4345	16	into	into	IN
cord-015021-pol2qm74	4345	17	three	three	CD
cord-015021-pol2qm74	4345	18	groups	group	NNS
cord-015021-pol2qm74	4345	19	by	by	IN
cord-015021-pol2qm74	4345	20	ultrafiltration	ultrafiltration	NN
cord-015021-pol2qm74	4345	21	(	(	-LRB-
cord-015021-pol2qm74	4345	22	UFPI	UFPI	NNP
cord-015021-pol2qm74	4345	23	TTK	TTK	NNP
cord-015021-pol2qm74	4345	24	,	,	,
cord-015021-pol2qm74	4345	25	30KD	30kd	CD
cord-015021-pol2qm74	4345	26	,	,	,
cord-015021-pol2qm74	4345	27	Milipore	Milipore	NNP
cord-015021-pol2qm74	4345	28	;	;	:
cord-015021-pol2qm74	4345	29	Centricon-10,10KD	centricon-10,10kd	PRP$
cord-015021-pol2qm74	4345	30	,	,	,
cord-015021-pol2qm74	4345	31	Amicon	Amicon	NNP
cord-015021-pol2qm74	4345	32	)	)	-RRB-
cord-015021-pol2qm74	4345	33	,	,	,
cord-015021-pol2qm74	4345	34	that	that	WDT
cord-015021-pol2qm74	4345	35	are	be	VBP
cord-015021-pol2qm74	4345	36	less	less	JJR
cord-015021-pol2qm74	4345	37	than	than	IN
cord-015021-pol2qm74	4345	38	10KD	10kd	CD
cord-015021-pol2qm74	4345	39	,	,	,
cord-015021-pol2qm74	4345	40	between	between	IN
cord-015021-pol2qm74	4345	41	i0	i0	NN
cord-015021-pol2qm74	4345	42	and	and	CC
cord-015021-pol2qm74	4345	43	30KD	30kd	CD
cord-015021-pol2qm74	4345	44	,	,	,
cord-015021-pol2qm74	4345	45	and	and	CC
cord-015021-pol2qm74	4345	46	more	more	JJR
cord-015021-pol2qm74	4345	47	than	than	IN
cord-015021-pol2qm74	4345	48	30KD	30kd	CD
cord-015021-pol2qm74	4345	49	.	.	.
cord-015021-pol2qm74	4346	1	Each	each	DT
cord-015021-pol2qm74	4346	2	group	group	NN
cord-015021-pol2qm74	4346	3	of	of	IN
cord-015021-pol2qm74	4346	4	the	the	DT
cord-015021-pol2qm74	4346	5	substances	substance	NNS
cord-015021-pol2qm74	4346	6	also	also	RB
cord-015021-pol2qm74	4346	7	was	be	VBD
cord-015021-pol2qm74	4346	8	tested	test	VBN
cord-015021-pol2qm74	4346	9	for	for	IN
cord-015021-pol2qm74	4346	10	the	the	DT
cord-015021-pol2qm74	4346	11	expression	expression	NN
cord-015021-pol2qm74	4346	12	of	of	IN
cord-015021-pol2qm74	4346	13	IL-2	IL-2	NNP
cord-015021-pol2qm74	4346	14	and	and	CC
cord-015021-pol2qm74	4346	15	IL-2R	IL-2R	NNP
cord-015021-pol2qm74	4346	16	by	by	IN
cord-015021-pol2qm74	4346	17	the	the	DT
cord-015021-pol2qm74	4346	18	dot	dot	NN
cord-015021-pol2qm74	4346	19	blot	blot	NN
cord-015021-pol2qm74	4346	20	hybridization	hybridization	NN
cord-015021-pol2qm74	4346	21	.	.	.
cord-015021-pol2qm74	4347	1	The	the	DT
cord-015021-pol2qm74	4347	2	results	result	NNS
cord-015021-pol2qm74	4347	3	showed	show	VBD
cord-015021-pol2qm74	4347	4	that	that	IN
cord-015021-pol2qm74	4347	5	:	:	:
cord-015021-pol2qm74	4347	6	i	i	LS
cord-015021-pol2qm74	4347	7	)	)	-RRB-
cord-015021-pol2qm74	4347	8	All	all	DT
cord-015021-pol2qm74	4347	9	sera	sera	NNP
cord-015021-pol2qm74	4347	10	from	from	IN
cord-015021-pol2qm74	4347	11	the	the	DT
cord-015021-pol2qm74	4347	12	rabbits	rabbit	NNS
cord-015021-pol2qm74	4347	13	after	after	IN
cord-015021-pol2qm74	4347	14	injury	injury	NN
cord-015021-pol2qm74	4347	15	had	have	VBD
cord-015021-pol2qm74	4347	16	significant	significant	JJ
cord-015021-pol2qm74	4347	17	suppression	suppression	NN
cord-015021-pol2qm74	4347	18	on	on	IN
cord-015021-pol2qm74	4347	19	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4347	20	proliferation	proliferation	NN
cord-015021-pol2qm74	4347	21	and	and	CC
cord-015021-pol2qm74	4347	22	secretion	secretion	NN
cord-015021-pol2qm74	4347	23	of	of	IN
cord-015021-pol2qm74	4347	24	IL-2	il-2	NN
cord-015021-pol2qm74	4347	25	by	by	IN
cord-015021-pol2qm74	4347	26	the	the	DT
cord-015021-pol2qm74	4347	27	Con	Con	NNP
cord-015021-pol2qm74	4347	28	A	A	NNP
cord-015021-pol2qm74	4347	29	-	-	HYPH
cord-015021-pol2qm74	4347	30	stimulated	stimulate	VBN
cord-015021-pol2qm74	4347	31	splenocyte	splenocyte	NNP
cord-015021-pol2qm74	4347	32	in	in	IN
cord-015021-pol2qm74	4347	33	mice	mouse	NNS
cord-015021-pol2qm74	4347	34	;	;	:
cord-015021-pol2qm74	4347	35	2	2	CD
cord-015021-pol2qm74	4347	36	)	)	-RRB-
cord-015021-pol2qm74	4348	1	The	the	DT
cord-015021-pol2qm74	4348	2	sera	sera	NNP
cord-015021-pol2qm74	4348	3	from	from	IN
cord-015021-pol2qm74	4348	4	the	the	DT
cord-015021-pol2qm74	4348	5	rabbits	rabbit	NNS
cord-015021-pol2qm74	4348	6	2	2	CD
cord-015021-pol2qm74	4348	7	days	day	NNS
cord-015021-pol2qm74	4348	8	after	after	IN
cord-015021-pol2qm74	4348	9	injury	injury	NN
cord-015021-pol2qm74	4348	10	had	have	VBD
cord-015021-pol2qm74	4348	11	more	more	RBR
cord-015021-pol2qm74	4348	12	profound	profound	JJ
cord-015021-pol2qm74	4348	13	suppression	suppression	NN
cord-015021-pol2qm74	4348	14	than	than	IN
cord-015021-pol2qm74	4348	15	other	other	JJ
cord-015021-pol2qm74	4348	16	injured	injure	VBN
cord-015021-pol2qm74	4348	17	sera	sera	NNP
cord-015021-pol2qm74	4348	18	;	;	:
cord-015021-pol2qm74	4348	19	3	3	LS
cord-015021-pol2qm74	4348	20	)	)	-RRB-
cord-015021-pol2qm74	4348	21	There	there	EX
cord-015021-pol2qm74	4348	22	was	be	VBD
cord-015021-pol2qm74	4348	23	a	a	DT
cord-015021-pol2qm74	4348	24	marked	marked	JJ
cord-015021-pol2qm74	4348	25	band	band	NN
cord-015021-pol2qm74	4348	26	at	at	IN
cord-015021-pol2qm74	4348	27	about	about	RB
cord-015021-pol2qm74	4348	28	10KD	10kd	CD
cord-015021-pol2qm74	4348	29	in	in	IN
cord-015021-pol2qm74	4348	30	sera	sera	NNP
cord-015021-pol2qm74	4348	31	from	from	IN
cord-015021-pol2qm74	4348	32	the	the	DT
cord-015021-pol2qm74	4348	33	rabbits	rabbit	NNS
cord-015021-pol2qm74	4348	34	2	2	CD
cord-015021-pol2qm74	4348	35	days	day	NNS
cord-015021-pol2qm74	4348	36	after	after	IN
cord-015021-pol2qm74	4348	37	injury	injury	NN
cord-015021-pol2qm74	4348	38	,	,	,
cord-015021-pol2qm74	4348	39	but	but	CC
cord-015021-pol2qm74	4348	40	nothing	nothing	NN
cord-015021-pol2qm74	4348	41	at	at	IN
cord-015021-pol2qm74	4348	42	the	the	DT
cord-015021-pol2qm74	4348	43	same	same	JJ
cord-015021-pol2qm74	4348	44	position	position	NN
cord-015021-pol2qm74	4348	45	in	in	IN
cord-015021-pol2qm74	4348	46	normal	normal	JJ
cord-015021-pol2qm74	4348	47	sera	sera	NNP
cord-015021-pol2qm74	4348	48	analyzed	analyze	VBD
cord-015021-pol2qm74	4348	49	with	with	IN
cord-015021-pol2qm74	4348	50	electrophoresis	electrophoresis	NN
cord-015021-pol2qm74	4348	51	;	;	:
cord-015021-pol2qm74	4348	52	4	4	LS
cord-015021-pol2qm74	4348	53	)	)	-RRB-
cord-015021-pol2qm74	4349	1	The	the	DT
cord-015021-pol2qm74	4349	2	substance	substance	NN
cord-015021-pol2qm74	4349	3	with	with	IN
cord-015021-pol2qm74	4349	4	molecular	molecular	JJ
cord-015021-pol2qm74	4349	5	weight	weight	NN
cord-015021-pol2qm74	4349	6	of	of	IN
cord-015021-pol2qm74	4349	7	about	about	RB
cord-015021-pol2qm74	4349	8	IOKD	IOKD	NNP
cord-015021-pol2qm74	4349	9	had	have	VBD
cord-015021-pol2qm74	4349	10	more	more	RBR
cord-015021-pol2qm74	4349	11	obvious	obvious	JJ
cord-015021-pol2qm74	4349	12	suppressive	suppressive	JJ
cord-015021-pol2qm74	4349	13	action	action	NN
cord-015021-pol2qm74	4349	14	on	on	IN
cord-015021-pol2qm74	4349	15	expression	expression	NN
cord-015021-pol2qm74	4349	16	of	of	IN
cord-015021-pol2qm74	4349	17	mRNA	mrna	NN
cord-015021-pol2qm74	4349	18	of	of	IN
cord-015021-pol2qm74	4349	19	IL-2	IL-2	NNP
cord-015021-pol2qm74	4349	20	and	and	CC
cord-015021-pol2qm74	4349	21	IL-2R	IL-2R	NNP
cord-015021-pol2qm74	4349	22	than	than	IN
cord-015021-pol2qm74	4349	23	other	other	JJ
cord-015021-pol2qm74	4349	24	groups	group	NNS
cord-015021-pol2qm74	4349	25	substances	substance	NNS
cord-015021-pol2qm74	4349	26	,	,	,
cord-015021-pol2qm74	4349	27	of	of	IN
cord-015021-pol2qm74	4349	28	which	which	WDT
cord-015021-pol2qm74	4349	29	molecular	molecular	JJ
cord-015021-pol2qm74	4349	30	weights	weight	NNS
cord-015021-pol2qm74	4349	31	are	be	VBP
cord-015021-pol2qm74	4349	32	more	more	JJR
cord-015021-pol2qm74	4349	33	than	than	IN
cord-015021-pol2qm74	4349	34	10KD	10kd	CD
cord-015021-pol2qm74	4349	35	.	.	.
cord-015021-pol2qm74	4350	1	It	-PRON-	PRP
cord-015021-pol2qm74	4350	2	is	be	VBZ
cord-015021-pol2qm74	4350	3	concluded	conclude	VBN
cord-015021-pol2qm74	4350	4	that	that	IN
cord-015021-pol2qm74	4350	5	:	:	:
cord-015021-pol2qm74	4350	6	I	i	NN
cord-015021-pol2qm74	4350	7	)	)	-RRB-
cord-015021-pol2qm74	4351	1	The	the	DT
cord-015021-pol2qm74	4351	2	sera	sera	NNP
cord-015021-pol2qm74	4351	3	from	from	IN
cord-015021-pol2qm74	4351	4	the	the	DT
cord-015021-pol2qm74	4351	5	injured	injure	VBN
cord-015021-pol2qm74	4351	6	rabbits	rabbit	NNS
cord-015021-pol2qm74	4351	7	can	can	MD
cord-015021-pol2qm74	4351	8	reduce	reduce	VB
cord-015021-pol2qm74	4351	9	immune	immune	JJ
cord-015021-pol2qm74	4351	10	response	response	NN
cord-015021-pol2qm74	4351	11	;	;	:
cord-015021-pol2qm74	4351	12	2	2	LS
cord-015021-pol2qm74	4351	13	)	)	-RRB-
cord-015021-pol2qm74	4351	14	There	there	EX
cord-015021-pol2qm74	4351	15	is	be	VBZ
cord-015021-pol2qm74	4351	16	kind	kind	RB
cord-015021-pol2qm74	4351	17	of	of	IN
cord-015021-pol2qm74	4351	18	substance	substance	NN
cord-015021-pol2qm74	4351	19	,	,	,
cord-015021-pol2qm74	4351	20	of	of	IN
cord-015021-pol2qm74	4351	21	which	which	WDT
cord-015021-pol2qm74	4351	22	molecular	molecular	JJ
cord-015021-pol2qm74	4351	23	weight	weight	NN
cord-015021-pol2qm74	4351	24	is	be	VBZ
cord-015021-pol2qm74	4351	25	about	about	RB
cord-015021-pol2qm74	4351	26	10KD	10kd	CD
cord-015021-pol2qm74	4351	27	,	,	,
cord-015021-pol2qm74	4351	28	it	-PRON-	PRP
cord-015021-pol2qm74	4351	29	is	be	VBZ
cord-015021-pol2qm74	4351	30	probable	probable	JJ
cord-015021-pol2qm74	4351	31	the	the	DT
cord-015021-pol2qm74	4351	32	main	main	JJ
cord-015021-pol2qm74	4351	33	factor	factor	NN
cord-015021-pol2qm74	4351	34	involved	involve	VBN
cord-015021-pol2qm74	4351	35	in	in	IN
cord-015021-pol2qm74	4351	36	the	the	DT
cord-015021-pol2qm74	4351	37	pathogenesie	pathogenesie	NNP
cord-015021-pol2qm74	4351	38	of	of	IN
cord-015021-pol2qm74	4351	39	postinjury	postinjury	NNP
cord-015021-pol2qm74	4351	40	suppression	suppression	NNP
cord-015021-pol2qm74	4351	41	immune	immune	NNP
cord-015021-pol2qm74	4351	42	;	;	:
cord-015021-pol2qm74	4351	43	3	3	LS
cord-015021-pol2qm74	4351	44	}	}	-RRB-
cord-015021-pol2qm74	4351	45	The	the	DT
cord-015021-pol2qm74	4351	46	substance	substance	NN
cord-015021-pol2qm74	4351	47	can	can	MD
cord-015021-pol2qm74	4351	48	depress	depress	VB
cord-015021-pol2qm74	4351	49	the	the	DT
cord-015021-pol2qm74	4351	50	expression	expression	NN
cord-015021-pol2qm74	4351	51	of	of	IN
cord-015021-pol2qm74	4351	52	mRNA	mrna	NN
cord-015021-pol2qm74	4351	53	of	of	IN
cord-015021-pol2qm74	4351	54	both	both	CC
cord-015021-pol2qm74	4351	55	IL-2	IL-2	NNP
cord-015021-pol2qm74	4351	56	and	and	CC
cord-015021-pol2qm74	4351	57	IL-2R.	IL-2R.	NNP
cord-015021-pol2qm74	4351	58	Research	Research	NNP
cord-015021-pol2qm74	4351	59	Institute	Institute	NNP
cord-015021-pol2qm74	4351	60	of	of	IN
cord-015021-pol2qm74	4351	61	Surgery	Surgery	NNP
cord-015021-pol2qm74	4351	62	Daping	Daping	NNP
cord-015021-pol2qm74	4351	63	,	,	,
cord-015021-pol2qm74	4351	64	Chongqing	Chongqing	NNP
cord-015021-pol2qm74	4351	65	,	,	,
cord-015021-pol2qm74	4351	66	630042	630042	CD
cord-015021-pol2qm74	4351	67	P.	P.	NNP
cord-015021-pol2qm74	4351	68	R.	R.	NNP
cord-015021-pol2qm74	4351	69	China	China	NNP
cord-015021-pol2qm74	4351	70	Acute	acute	JJ
cord-015021-pol2qm74	4351	71	ethanol	ethanol	NN
cord-015021-pol2qm74	4351	72	uptake	uptake	NN
cord-015021-pol2qm74	4351	73	prior	prior	RB
cord-015021-pol2qm74	4351	74	to	to	IN
cord-015021-pol2qm74	4351	75	injury	injury	NN
cord-015021-pol2qm74	4351	76	modulates	modulate	VBZ
cord-015021-pol2qm74	4351	77	monocyte	monocyte	NNP
cord-015021-pol2qm74	4351	78	TNFo~	TNFo~	NNP
cord-015021-pol2qm74	4351	79	,	,	,
cord-015021-pol2qm74	4351	80	production	production	NN
cord-015021-pol2qm74	4351	81	and	and	CC
cord-015021-pol2qm74	4351	82	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	4351	83	cell	cell	NN
cord-015021-pol2qm74	4351	84	apoptosis	apoptosis	NN
cord-015021-pol2qm74	4351	85	.	.	.
cord-015021-pol2qm74	4352	1	G.	G.	NNP
cord-015021-pol2qm74	4352	2	Szabo	Szabo	NNP
cord-015021-pol2qm74	4352	3	,	,	,
cord-015021-pol2qm74	4352	4	B.	B.	NNP
cord-015021-pol2qm74	4352	5	Verma	Verma	NNP
cord-015021-pol2qm74	4352	6	,	,	,
cord-015021-pol2qm74	4352	7	P.	P.	NNP
cord-015021-pol2qm74	4352	8	Mandrekar	Mandrekar	NNP
cord-015021-pol2qm74	4352	9	,	,	,
cord-015021-pol2qm74	4352	10	D.	D.	NNP
cord-015021-pol2qm74	4352	11	Catalano	Catalano	NNP
cord-015021-pol2qm74	4352	12	Monocytes	Monocytes	NNP
cord-015021-pol2qm74	4352	13	(	(	-LRB-
cord-015021-pol2qm74	4352	14	MO	MO	NNP
cord-015021-pol2qm74	4352	15	)	)	-RRB-
cord-015021-pol2qm74	4352	16	have	have	VBP
cord-015021-pol2qm74	4352	17	been	be	VBN
cord-015021-pol2qm74	4352	18	shown	show	VBN
cord-015021-pol2qm74	4352	19	to	to	TO
cord-015021-pol2qm74	4352	20	contribute	contribute	VB
cord-015021-pol2qm74	4352	21	to	to	IN
cord-015021-pol2qm74	4352	22	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	4352	23	after	after	IN
cord-015021-pol2qm74	4352	24	both	both	DT
cord-015021-pol2qm74	4352	25	major	major	JJ
cord-015021-pol2qm74	4352	26	injury	injury	NN
cord-015021-pol2qm74	4352	27	and	and	CC
cord-015021-pol2qm74	4352	28	alcohol	alcohol	NN
cord-015021-pol2qm74	4352	29	consumption	consumption	NN
cord-015021-pol2qm74	4352	30	.	.	.
cord-015021-pol2qm74	4353	1	We	-PRON-	PRP
cord-015021-pol2qm74	4353	2	reported	report	VBD
cord-015021-pol2qm74	4353	3	that	that	IN
cord-015021-pol2qm74	4353	4	acute	acute	JJ
cord-015021-pol2qm74	4353	5	ethanol	ethanol	NN
cord-015021-pol2qm74	4353	6	exposure	exposure	NN
cord-015021-pol2qm74	4353	7	of	of	IN
cord-015021-pol2qm74	4353	8	M(3	M(3	NNP
cord-015021-pol2qm74	4353	9	results	result	NNS
cord-015021-pol2qm74	4353	10	in	in	IN
cord-015021-pol2qm74	4353	11	decreased	decrease	VBN
cord-015021-pol2qm74	4353	12	antigen	antigen	NN
cord-015021-pol2qm74	4353	13	presentation	presentation	NN
cord-015021-pol2qm74	4353	14	,	,	,
cord-015021-pol2qm74	4353	15	induces	induce	VBZ
cord-015021-pol2qm74	4353	16	TGF-13	TGF-13	NNP
cord-015021-pol2qm74	4353	17	and	and	CC
cord-015021-pol2qm74	4353	18	PGE2	PGE2	NNP
cord-015021-pol2qm74	4353	19	while	while	IN
cord-015021-pol2qm74	4353	20	inhibiting	inhibit	VBG
cord-015021-pol2qm74	4353	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4353	22	monokine	monokine	JJ
cord-015021-pol2qm74	4353	23	production	production	NN
cord-015021-pol2qm74	4353	24	.	.	.
cord-015021-pol2qm74	4354	1	We	-PRON-	PRP
cord-015021-pol2qm74	4354	2	also	also	RB
cord-015021-pol2qm74	4354	3	showed	show	VBD
cord-015021-pol2qm74	4354	4	that	that	IN
cord-015021-pol2qm74	4354	5	post	post	JJ
cord-015021-pol2qm74	4354	6	-	-	JJ
cord-015021-pol2qm74	4354	7	trauma	trauma	JJ
cord-015021-pol2qm74	4354	8	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	4354	9	is	be	VBZ
cord-015021-pol2qm74	4354	10	mediated	mediate	VBN
cord-015021-pol2qm74	4354	11	by	by	IN
cord-015021-pol2qm74	4355	1	hyper	hyper	JJ
cord-015021-pol2qm74	4355	2	-	-	JJ
cord-015021-pol2qm74	4355	3	elevated	elevated	JJ
cord-015021-pol2qm74	4355	4	MO	MO	NNP
cord-015021-pol2qm74	4355	5	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	4355	6	and	and	CC
cord-015021-pol2qm74	4355	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	4355	8	.	.	.
cord-015021-pol2qm74	4356	1	Consequently	consequently	RB
cord-015021-pol2qm74	4356	2	,	,	,
cord-015021-pol2qm74	4356	3	here	here	RB
cord-015021-pol2qm74	4356	4	we	-PRON-	PRP
cord-015021-pol2qm74	4356	5	investigated	investigate	VBD
cord-015021-pol2qm74	4356	6	rnonokine	rnonokine	JJ
cord-015021-pol2qm74	4356	7	production	production	NN
cord-015021-pol2qm74	4356	8	in	in	IN
cord-015021-pol2qm74	4356	9	trauma	trauma	NN
cord-015021-pol2qm74	4356	10	patients	patient	NNS
cord-015021-pol2qm74	4356	11	(	(	-LRB-
cord-015021-pol2qm74	4356	12	n=10	n=10	NNP
cord-015021-pol2qm74	4356	13	)	)	-RRB-
cord-015021-pol2qm74	4356	14	who	who	WP
cord-015021-pol2qm74	4356	15	had	have	VBD
cord-015021-pol2qm74	4356	16	elevated	elevate	VBN
cord-015021-pol2qm74	4356	17	(	(	-LRB-
cord-015021-pol2qm74	4356	18	>	>	XX
cord-015021-pol2qm74	4356	19	O.lmg/dl	O.lmg/dl	NNP
cord-015021-pol2qm74	4356	20	)	)	-RRB-
cord-015021-pol2qm74	4356	21	or	or	CC
cord-015021-pol2qm74	4356	22	had	have	VBD
cord-015021-pol2qm74	4356	23	no	no	DT
cord-015021-pol2qm74	4356	24	blood	blood	NN
cord-015021-pol2qm74	4356	25	alcohol	alcohol	NN
cord-015021-pol2qm74	4356	26	level	level	NN
cord-015021-pol2qm74	4356	27	(	(	-LRB-
cord-015021-pol2qm74	4356	28	n	n	NN
cord-015021-pol2qm74	4356	29	=	=	NN
cord-015021-pol2qm74	4356	30	t0	t0	NNP
cord-015021-pol2qm74	4356	31	)	)	-RRB-
cord-015021-pol2qm74	4356	32	at	at	IN
cord-015021-pol2qm74	4356	33	the	the	DT
cord-015021-pol2qm74	4356	34	time	time	NN
cord-015021-pol2qm74	4356	35	of	of	IN
cord-015021-pol2qm74	4356	36	emergency	emergency	NN
cord-015021-pol2qm74	4356	37	room	room	NN
cord-015021-pol2qm74	4356	38	admission	admission	NN
cord-015021-pol2qm74	4356	39	.	.	.
cord-015021-pol2qm74	4357	1	None	none	NN
cord-015021-pol2qm74	4357	2	of	of	IN
cord-015021-pol2qm74	4357	3	the	the	DT
cord-015021-pol2qm74	4357	4	patients	patient	NNS
cord-015021-pol2qm74	4357	5	had	have	VBD
cord-015021-pol2qm74	4357	6	chronic	chronic	JJ
cord-015021-pol2qm74	4357	7	alcohol	alcohol	NN
cord-015021-pol2qm74	4357	8	use	use	NN
cord-015021-pol2qm74	4357	9	history	history	NN
cord-015021-pol2qm74	4357	10	.	.	.
cord-015021-pol2qm74	4358	1	Met	Met	NNP
cord-015021-pol2qm74	4358	2	TNFc~	tnfc~	IN
cord-015021-pol2qm74	4358	3	production	production	NN
cord-015021-pol2qm74	4358	4	from	from	IN
cord-015021-pol2qm74	4358	5	trauma	trauma	NN
cord-015021-pol2qm74	4358	6	patients	patient	NNS
cord-015021-pol2qm74	4358	7	with	with	IN
cord-015021-pol2qm74	4358	8	prior	prior	JJ
cord-015021-pol2qm74	4358	9	alcohol	alcohol	NN
cord-015021-pol2qm74	4358	10	uptake	uptake	NN
cord-015021-pol2qm74	4358	11	was	be	VBD
cord-015021-pol2qm74	4358	12	undetectable	undetectable	JJ
cord-015021-pol2qm74	4358	13	during	during	IN
cord-015021-pol2qm74	4358	14	days	day	NNS
cord-015021-pol2qm74	4358	15	0	0	CD
cord-015021-pol2qm74	4358	16	-	-	SYM
cord-015021-pol2qm74	4358	17	3	3	CD
cord-015021-pol2qm74	4358	18	post	post	JJ
cord-015021-pol2qm74	4358	19	-	-	JJ
cord-015021-pol2qm74	4358	20	injury	injury	NN
cord-015021-pol2qm74	4358	21	in	in	IN
cord-015021-pol2qm74	4358	22	contrast	contrast	NN
cord-015021-pol2qm74	4358	23	to	to	IN
cord-015021-pol2qm74	4358	24	patients	patient	NNS
cord-015021-pol2qm74	4358	25	without	without	IN
cord-015021-pol2qm74	4358	26	alcohol	alcohol	NN
cord-015021-pol2qm74	4358	27	exposure	exposure	NN
cord-015021-pol2qm74	4358	28	.	.	.
cord-015021-pol2qm74	4359	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	4359	2	,	,	,
cord-015021-pol2qm74	4359	3	decreased	decrease	VBD
cord-015021-pol2qm74	4359	4	TNF	TNF	NNP
cord-015021-pol2qm74	4360	1	~x	~x	NNP
cord-015021-pol2qm74	4360	2	levels	level	NNS
cord-015021-pol2qm74	4360	3	were	be	VBD
cord-015021-pol2qm74	4360	4	found	find	VBN
cord-015021-pol2qm74	4360	5	in	in	IN
cord-015021-pol2qm74	4360	6	alcoholic	alcoholic	JJ
cord-015021-pol2qm74	4360	7	patients	patient	NNS
cord-015021-pol2qm74	4360	8	'	'	POS
cord-015021-pol2qm74	4360	9	MCi	MCi	NNS
cord-015021-pol2qm74	4360	10	after	after	IN
cord-015021-pol2qm74	4360	11	MDP	MDP	NNP
cord-015021-pol2qm74	4360	12	or	or	CC
cord-015021-pol2qm74	4360	13	IFNy	IFNy	NNPS
cord-015021-pol2qm74	4360	14	+	+	CC
cord-015021-pol2qm74	4361	1	MDP	MDP	NNP
cord-015021-pol2qm74	4361	2	induction	induction	NN
cord-015021-pol2qm74	4361	3	.	.	.
cord-015021-pol2qm74	4362	1	However	however	RB
cord-015021-pol2qm74	4362	2	,	,	,
cord-015021-pol2qm74	4362	3	MCl	MCl	NNS
cord-015021-pol2qm74	4362	4	TNFc~	tnfc~	IN
cord-015021-pol2qm74	4362	5	levels	level	NNS
cord-015021-pol2qm74	4362	6	during	during	IN
cord-015021-pol2qm74	4362	7	the	the	DT
cord-015021-pol2qm74	4362	8	4	4	CD
cord-015021-pol2qm74	4362	9	-	-	SYM
cord-015021-pol2qm74	4362	10	8	8	CD
cord-015021-pol2qm74	4362	11	days	day	NNS
cord-015021-pol2qm74	4362	12	post	post	NN
cord-015021-pol2qm74	4362	13	injury	injury	NN
cord-015021-pol2qm74	4362	14	period	period	NN
cord-015021-pol2qm74	4362	15	became	become	VBD
cord-015021-pol2qm74	4362	16	higher	high	JJR
cord-015021-pol2qm74	4362	17	in	in	IN
cord-015021-pol2qm74	4362	18	alcoholic	alcoholic	JJ
cord-015021-pol2qm74	4362	19	trauma	trauma	NN
cord-015021-pol2qm74	4362	20	patients	patient	NNS
cord-015021-pol2qm74	4362	21	.	.	.
cord-015021-pol2qm74	4363	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	4363	2	,	,	,
cord-015021-pol2qm74	4363	3	over	over	IN
cord-015021-pol2qm74	4363	4	9	9	CD
cord-015021-pol2qm74	4363	5	days	day	NNS
cord-015021-pol2qm74	4363	6	post	post	NN
cord-015021-pol2qm74	4363	7	-	-	JJ
cord-015021-pol2qm74	4363	8	injury	injury	JJ
cord-015021-pol2qm74	4363	9	,	,	,
cord-015021-pol2qm74	4363	10	alcoholic	alcoholic	JJ
cord-015021-pol2qm74	4363	11	trauma	trauma	NN
cord-015021-pol2qm74	4363	12	patients	patient	NNS
cord-015021-pol2qm74	4363	13	showed	show	VBD
cord-015021-pol2qm74	4363	14	significantly	significantly	RB
cord-015021-pol2qm74	4363	15	elevated	elevated	JJ
cord-015021-pol2qm74	4363	16	MCi	MCi	NNS
cord-015021-pol2qm74	4363	17	TNFo~	TNFo~	NNS
cord-015021-pol2qm74	4363	18	production	production	NN
cord-015021-pol2qm74	4363	19	after	after	IN
cord-015021-pol2qm74	4363	20	adherence	adherence	NN
cord-015021-pol2qm74	4363	21	isolation	isolation	NN
cord-015021-pol2qm74	4363	22	,	,	,
cord-015021-pol2qm74	4363	23	MDP	MDP	NNP
cord-015021-pol2qm74	4363	24	,	,	,
cord-015021-pol2qm74	4363	25	or	or	CC
cord-015021-pol2qm74	4363	26	IFN+MDP	ifn+mdp	JJ
cord-015021-pol2qm74	4363	27	stimulation	stimulation	NN
cord-015021-pol2qm74	4363	28	compared	compare	VBN
cord-015021-pol2qm74	4363	29	to	to	IN
cord-015021-pol2qm74	4363	30	patients	patient	NNS
cord-015021-pol2qm74	4363	31	without	without	IN
cord-015021-pol2qm74	4363	32	alcohol	alcohol	NN
cord-015021-pol2qm74	4363	33	.	.	.
cord-015021-pol2qm74	4364	1	These	these	DT
cord-015021-pol2qm74	4364	2	results	result	NNS
cord-015021-pol2qm74	4364	3	suggest	suggest	VBP
cord-015021-pol2qm74	4364	4	that	that	IN
cord-015021-pol2qm74	4364	5	acute	acute	JJ
cord-015021-pol2qm74	4364	6	ethanol	ethanol	NN
cord-015021-pol2qm74	4364	7	uptake	uptake	NN
cord-015021-pol2qm74	4364	8	prior	prior	RB
cord-015021-pol2qm74	4364	9	to	to	IN
cord-015021-pol2qm74	4364	10	injury	injury	NN
cord-015021-pol2qm74	4364	11	decreases	decrease	VBZ
cord-015021-pol2qm74	4364	12	TNF(x	tnf(x	NN
cord-015021-pol2qm74	4364	13	inducibility	inducibility	NN
cord-015021-pol2qm74	4364	14	in	in	IN
cord-015021-pol2qm74	4364	15	the	the	DT
cord-015021-pol2qm74	4364	16	early	early	JJ
cord-015021-pol2qm74	4364	17	post	post	JJ
cord-015021-pol2qm74	4364	18	-	-	JJ
cord-015021-pol2qm74	4364	19	trauma	trauma	JJ
cord-015021-pol2qm74	4364	20	period	period	NN
cord-015021-pol2qm74	4364	21	,	,	,
cord-015021-pol2qm74	4364	22	but	but	CC
cord-015021-pol2qm74	4365	1	these	these	DT
cord-015021-pol2qm74	4365	2	patients	patient	NNS
cord-015021-pol2qm74	4365	3	'	'	POS
cord-015021-pol2qm74	4365	4	MO	MO	NNP
cord-015021-pol2qm74	4365	5	produce	produce	VBP
cord-015021-pol2qm74	4365	6	hyper	hyper	JJ
cord-015021-pol2qm74	4365	7	-	-	JJ
cord-015021-pol2qm74	4365	8	elevated	elevated	JJ
cord-015021-pol2qm74	4365	9	TNFa	TNFa	NNS
cord-015021-pol2qm74	4365	10	levels	level	NNS
cord-015021-pol2qm74	4365	11	later	later	RB
cord-015021-pol2qm74	4365	12	post	post	JJ
cord-015021-pol2qm74	4365	13	-	-	JJ
cord-015021-pol2qm74	4365	14	injury	injury	NN
cord-015021-pol2qm74	4365	15	,	,	,
cord-015021-pol2qm74	4365	16	thereby	thereby	RB
cord-015021-pol2qm74	4365	17	prolonging	prolong	VBG
cord-015021-pol2qm74	4365	18	their	-PRON-	PRP$
cord-015021-pol2qm74	4365	19	cytokine	cytokine	NN
cord-015021-pol2qm74	4365	20	shock	shock	NN
cord-015021-pol2qm74	4365	21	risk	risk	NN
cord-015021-pol2qm74	4365	22	.	.	.
cord-015021-pol2qm74	4366	1	TNF	TNF	NNP
cord-015021-pol2qm74	4366	2	ng	ng	NNP
cord-015021-pol2qm74	4366	3	/	/	SYM
cord-015021-pol2qm74	4366	4	ml	ml	NN
cord-015021-pol2qm74	4366	5	0	0	CD
cord-015021-pol2qm74	4366	6	-	-	SYM
cord-015021-pol2qm74	4366	7	3	3	CD
cord-015021-pol2qm74	4366	8	days	day	NNS
cord-015021-pol2qm74	4366	9	post	post	JJ
cord-015021-pol2qm74	4366	10	-	-	JJ
cord-015021-pol2qm74	4366	11	injury	injury	NN
cord-015021-pol2qm74	4367	1	9	9	CD
cord-015021-pol2qm74	4367	2	days	day	NNS
cord-015021-pol2qm74	4367	3	post	post	VBP
cord-015021-pol2qm74	4367	4	injury	injury	NN
cord-015021-pol2qm74	4367	5	Stimulus	Stimulus	NNP
cord-015021-pol2qm74	4367	6	Ale	Ale	NNP
cord-015021-pol2qm74	4367	7	.	.	.
cord-015021-pol2qm74	4368	1	Pt	Pt	NNP
cord-015021-pol2qm74	4368	2	.	.	.
cord-015021-pol2qm74	4369	1	Pt	Pt	NNP
cord-015021-pol2qm74	4369	2	9.3	9.3	CD
cord-015021-pol2qm74	4369	3	11.9	11.9	CD
cord-015021-pol2qm74	4369	4	5.6	5.6	CD
cord-015021-pol2qm74	4369	5	4.0	4.0	CD
cord-015021-pol2qm74	4369	6	Immunosuppression	Immunosuppression	NNP
cord-015021-pol2qm74	4369	7	might	may	MD
cord-015021-pol2qm74	4369	8	also	also	RB
cord-015021-pol2qm74	4369	9	be	be	VB
cord-015021-pol2qm74	4369	10	increased	increase	VBN
cord-015021-pol2qm74	4369	11	by	by	IN
cord-015021-pol2qm74	4369	12	the	the	DT
cord-015021-pol2qm74	4369	13	elevated	elevated	JJ
cord-015021-pol2qm74	4369	14	apoptotic	apoptotic	JJ
cord-015021-pol2qm74	4369	15	activity	activity	NN
cord-015021-pol2qm74	4369	16	found	find	VBN
cord-015021-pol2qm74	4369	17	in	in	IN
cord-015021-pol2qm74	4369	18	trauma	trauma	NN
cord-015021-pol2qm74	4369	19	patients	patient	NNS
cord-015021-pol2qm74	4369	20	'	'	POS
cord-015021-pol2qm74	4369	21	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	4369	22	ceils	ceil	NNS
cord-015021-pol2qm74	4369	23	,	,	,
cord-015021-pol2qm74	4369	24	which	which	WDT
cord-015021-pol2qm74	4369	25	was	be	VBD
cord-015021-pol2qm74	4369	26	even	even	RB
cord-015021-pol2qm74	4369	27	greater	great	JJR
cord-015021-pol2qm74	4369	28	in	in	IN
cord-015021-pol2qm74	4369	29	alcoholic	alcoholic	JJ
cord-015021-pol2qm74	4369	30	trauma	trauma	NN
cord-015021-pol2qm74	4369	31	patients	patient	NNS
cord-015021-pol2qm74	4369	32	'	'	POS
cord-015021-pol2qm74	4369	33	cells	cell	NNS
cord-015021-pol2qm74	4369	34	.	.	.
cord-015021-pol2qm74	4370	1	In	in	IN
cord-015021-pol2qm74	4370	2	non	non	JJ
cord-015021-pol2qm74	4370	3	-	-	JJ
cord-015021-pol2qm74	4370	4	alcoholic	alcoholic	JJ
cord-015021-pol2qm74	4370	5	trauma	trauma	NN
cord-015021-pol2qm74	4370	6	patients	patient	NNS
cord-015021-pol2qm74	4370	7	'	'	POS
cord-015021-pol2qm74	4370	8	preactivated	preactivated	JJ
cord-015021-pol2qm74	4370	9	MO	MO	NNP
cord-015021-pol2qm74	4370	10	,	,	,
cord-015021-pol2qm74	4370	11	in	in	IN
cord-015021-pol2qm74	4370	12	vitro	vitro	FW
cord-015021-pol2qm74	4370	13	acute	acute	JJ
cord-015021-pol2qm74	4370	14	ethanol	ethanol	NN
cord-015021-pol2qm74	4370	15	(	(	-LRB-
cord-015021-pol2qm74	4370	16	25	25	CD
cord-015021-pol2qm74	4370	17	-	-	HYPH
cord-015021-pol2qm74	4370	18	150mM	150mm	CD
cord-015021-pol2qm74	4370	19	)	)	-RRB-
cord-015021-pol2qm74	4370	20	exposure	exposure	NN
cord-015021-pol2qm74	4370	21	resulted	result	VBD
cord-015021-pol2qm74	4370	22	in	in	IN
cord-015021-pol2qm74	4370	23	a	a	DT
cord-015021-pol2qm74	4370	24	significant	significant	JJ
cord-015021-pol2qm74	4370	25	down	down	NN
cord-015021-pol2qm74	4370	26	-	-	HYPH
cord-015021-pol2qm74	4370	27	regulation	regulation	NN
cord-015021-pol2qm74	4370	28	of	of	IN
cord-015021-pol2qm74	4370	29	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	4370	30	(	(	-LRB-
cord-015021-pol2qm74	4370	31	p<0.001	p<0.001	CD
cord-015021-pol2qm74	4370	32	)	)	-RRB-
cord-015021-pol2qm74	4370	33	and	and	CC
cord-015021-pol2qm74	4371	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	4371	2	(	(	-LRB-
cord-015021-pol2qm74	4371	3	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	4371	4	)	)	-RRB-
cord-015021-pol2qm74	4371	5	production	production	NN
cord-015021-pol2qm74	4371	6	.	.	.
cord-015021-pol2qm74	4372	1	In	in	IN
cord-015021-pol2qm74	4372	2	contrast	contrast	NN
cord-015021-pol2qm74	4372	3	,	,	,
cord-015021-pol2qm74	4372	4	in	in	IN
cord-015021-pol2qm74	4372	5	vitro	vitro	FW
cord-015021-pol2qm74	4372	6	ethanol	ethanol	NN
cord-015021-pol2qm74	4372	7	exposure	exposure	NN
cord-015021-pol2qm74	4372	8	increased	increase	VBD
cord-015021-pol2qm74	4372	9	the	the	DT
cord-015021-pol2qm74	4372	10	production	production	NN
cord-015021-pol2qm74	4372	11	of	of	IN
cord-015021-pol2qm74	4372	12	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	4372	13	monokine	monokine	NN
cord-015021-pol2qm74	4372	14	,	,	,
cord-015021-pol2qm74	4372	15	TGFI	TGFI	NNP
cord-015021-pol2qm74	4372	16	]	]	-RRB-
cord-015021-pol2qm74	4372	17	.	.	.
cord-015021-pol2qm74	4373	1	These	these	DT
cord-015021-pol2qm74	4373	2	results	result	NNS
cord-015021-pol2qm74	4373	3	provide	provide	VBP
cord-015021-pol2qm74	4373	4	both	both	DT
cord-015021-pol2qm74	4373	5	in	in	IN
cord-015021-pol2qm74	4373	6	vivo	vivo	NN
cord-015021-pol2qm74	4373	7	and	and	CC
cord-015021-pol2qm74	4373	8	in	in	IN
cord-015021-pol2qm74	4373	9	vitro	vitro	FW
cord-015021-pol2qm74	4373	10	evidence	evidence	NN
cord-015021-pol2qm74	4373	11	for	for	IN
cord-015021-pol2qm74	4373	12	the	the	DT
cord-015021-pol2qm74	4373	13	effect	effect	NN
cord-015021-pol2qm74	4373	14	of	of	IN
cord-015021-pol2qm74	4373	15	acute	acute	JJ
cord-015021-pol2qm74	4373	16	ethanol	ethanol	NN
cord-015021-pol2qm74	4373	17	exposure	exposure	NN
cord-015021-pol2qm74	4373	18	increasing	increase	VBG
cord-015021-pol2qm74	4373	19	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	4373	20	and	and	CC
cord-015021-pol2qm74	4373	21	cytokine	cytokine	NN
cord-015021-pol2qm74	4373	22	shock	shock	NN
cord-015021-pol2qm74	4373	23	.	.	.
cord-015021-pol2qm74	4374	1	The	the	DT
cord-015021-pol2qm74	4374	2	'	'	``
cord-015021-pol2qm74	4374	3	systemic	systemic	JJ
cord-015021-pol2qm74	4374	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4374	5	response	response	NN
cord-015021-pol2qm74	4374	6	syndrome	syndrome	NN
cord-015021-pol2qm74	4374	7	'	'	''
cord-015021-pol2qm74	4374	8	(	(	-LRB-
cord-015021-pol2qm74	4374	9	SIRS	sirs	UH
cord-015021-pol2qm74	4374	10	)	)	-RRB-
cord-015021-pol2qm74	4374	11	with	with	IN
cord-015021-pol2qm74	4374	12	consecutive	consecutive	JJ
cord-015021-pol2qm74	4374	13	septic	septic	JJ
cord-015021-pol2qm74	4374	14	multi	multi	JJ
cord-015021-pol2qm74	4374	15	-	-	JJ
cord-015021-pol2qm74	4374	16	organ	organ	JJ
cord-015021-pol2qm74	4374	17	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4374	18	represents	represent	VBZ
cord-015021-pol2qm74	4374	19	the	the	DT
cord-015021-pol2qm74	4374	20	major	major	JJ
cord-015021-pol2qm74	4374	21	cause	cause	NN
cord-015021-pol2qm74	4374	22	of	of	IN
cord-015021-pol2qm74	4374	23	late	late	JJ
cord-015021-pol2qm74	4374	24	death	death	NN
cord-015021-pol2qm74	4374	25	following	follow	VBG
cord-015021-pol2qm74	4374	26	major	major	JJ
cord-015021-pol2qm74	4374	27	mechanical	mechanical	JJ
cord-015021-pol2qm74	4374	28	and	and	CC
cord-015021-pol2qm74	4374	29	burn	burn	VB
cord-015021-pol2qm74	4374	30	trauma	trauma	NN
cord-015021-pol2qm74	4374	31	.	.	.
cord-015021-pol2qm74	4375	1	Systemic	systemic	JJ
cord-015021-pol2qm74	4375	2	hyperinflammation	hyperinflammation	NN
cord-015021-pol2qm74	4375	3	and	and	CC
cord-015021-pol2qm74	4375	4	concurrent	concurrent	JJ
cord-015021-pol2qm74	4375	5	depression	depression	NN
cord-015021-pol2qm74	4375	6	of	of	IN
cord-015021-pol2qm74	4375	7	cell	cell	NN
cord-015021-pol2qm74	4375	8	mediated	mediate	VBN
cord-015021-pol2qm74	4375	9	immune	immune	JJ
cord-015021-pol2qm74	4375	10	response	response	NN
cord-015021-pol2qm74	4375	11	(	(	-LRB-
cord-015021-pol2qm74	4375	12	CMI	CMI	NNP
cord-015021-pol2qm74	4375	13	)	)	-RRB-
cord-015021-pol2qm74	4375	14	render	render	VBP
cord-015021-pol2qm74	4375	15	the	the	DT
cord-015021-pol2qm74	4375	16	traumatized	traumatize	VBN
cord-015021-pol2qm74	4375	17	host	host	NN
cord-015021-pol2qm74	4375	18	anergic	anergic	NN
cord-015021-pol2qm74	4375	19	,	,	,
cord-015021-pol2qm74	4375	20	resulting	result	VBG
cord-015021-pol2qm74	4375	21	in	in	IN
cord-015021-pol2qm74	4375	22	profound	profound	JJ
cord-015021-pol2qm74	4375	23	susceptibility	susceptibility	NN
cord-015021-pol2qm74	4375	24	to	to	IN
cord-015021-pol2qm74	4375	25	opportunistic	opportunistic	JJ
cord-015021-pol2qm74	4375	26	infection	infection	NN
cord-015021-pol2qm74	4375	27	.	.	.
cord-015021-pol2qm74	4376	1	Monooytes	monooyte	NNS
cord-015021-pol2qm74	4376	2	/	/	SYM
cord-015021-pol2qm74	4376	3	macrophages	macrophage	NNS
cord-015021-pol2qm74	4376	4	(	(	-LRB-
cord-015021-pol2qm74	4376	5	MO	MO	NNP
cord-015021-pol2qm74	4376	6	)	)	-RRB-
cord-015021-pol2qm74	4376	7	play	play	VBP
cord-015021-pol2qm74	4376	8	a	a	DT
cord-015021-pol2qm74	4376	9	central	central	JJ
cord-015021-pol2qm74	4376	10	role	role	NN
cord-015021-pol2qm74	4376	11	within	within	IN
cord-015021-pol2qm74	4376	12	the	the	DT
cord-015021-pol2qm74	4376	13	host	host	NN
cord-015021-pol2qm74	4376	14	defense	defense	NN
cord-015021-pol2qm74	4376	15	system	system	NN
cord-015021-pol2qm74	4376	16	in	in	IN
cord-015021-pol2qm74	4376	17	developing	develop	VBG
cord-015021-pol2qm74	4376	18	and	and	CC
cord-015021-pol2qm74	4376	19	manifesting	manifest	VBG
cord-015021-pol2qm74	4376	20	states	state	NNS
cord-015021-pol2qm74	4376	21	of	of	IN
cord-015021-pol2qm74	4376	22	injury	injury	NN
cord-015021-pol2qm74	4376	23	,	,	,
cord-015021-pol2qm74	4376	24	shock	shock	NN
cord-015021-pol2qm74	4376	25	and	and	CC
cord-015021-pol2qm74	4376	26	sepsis	sepsis	NN
cord-015021-pol2qm74	4376	27	.	.	.
cord-015021-pol2qm74	4377	1	The	the	DT
cord-015021-pol2qm74	4377	2	mechanistic	mechanistic	JJ
cord-015021-pol2qm74	4377	3	scrutiny	scrutiny	NN
cord-015021-pol2qm74	4377	4	of	of	IN
cord-015021-pol2qm74	4377	5	the	the	DT
cord-015021-pol2qm74	4377	6	synthesis	synthesis	NN
cord-015021-pol2qm74	4377	7	patterns	pattern	NNS
cord-015021-pol2qm74	4377	8	of	of	IN
cord-015021-pol2qm74	4377	9	crucial	crucial	JJ
cord-015021-pol2qm74	4377	10	cccytokines	cccytokine	NNS
cord-015021-pol2qm74	4377	11	appears	appear	VBZ
cord-015021-pol2qm74	4377	12	to	to	TO
cord-015021-pol2qm74	4377	13	be	be	VB
cord-015021-pol2qm74	4377	14	a	a	DT
cord-015021-pol2qm74	4377	15	helpful	helpful	JJ
cord-015021-pol2qm74	4377	16	tool	tool	NN
cord-015021-pol2qm74	4377	17	to	to	TO
cord-015021-pol2qm74	4377	18	further	further	RB
cord-015021-pol2qm74	4377	19	analyse	analyse	VB
cord-015021-pol2qm74	4377	20	MO	MO	NNP
cord-015021-pol2qm74	4377	21	behaviour	behaviour	NN
cord-015021-pol2qm74	4377	22	in	in	IN
cord-015021-pol2qm74	4377	23	the	the	DT
cord-015021-pol2qm74	4377	24	compromised	compromised	JJ
cord-015021-pol2qm74	4377	25	individual	individual	NN
cord-015021-pol2qm74	4377	26	.	.	.
cord-015021-pol2qm74	4378	1	The	the	DT
cord-015021-pol2qm74	4378	2	objective	objective	NN
cord-015021-pol2qm74	4378	3	of	of	IN
cord-015021-pol2qm74	4378	4	this	this	DT
cord-015021-pol2qm74	4378	5	study	study	NN
cord-015021-pol2qm74	4378	6	was	be	VBD
cord-015021-pol2qm74	4378	7	to	to	TO
cord-015021-pol2qm74	4378	8	further	further	RB
cord-015021-pol2qm74	4378	9	dissect	dissect	VB
cord-015021-pol2qm74	4378	10	the	the	DT
cord-015021-pol2qm74	4378	11	characteristics	characteristic	NNS
cord-015021-pol2qm74	4378	12	of	of	IN
cord-015021-pol2qm74	4378	13	cytokine	cytokine	NN
cord-015021-pol2qm74	4378	14	regulation	regulation	NN
cord-015021-pol2qm74	4378	15	in	in	IN
cord-015021-pol2qm74	4378	16	PBMC	PBMC	NNP
cord-015021-pol2qm74	4378	17	under	under	IN
cord-015021-pol2qm74	4378	18	stressful	stressful	JJ
cord-015021-pol2qm74	4378	19	conditions	condition	NNS
cord-015021-pol2qm74	4378	20	,	,	,
cord-015021-pol2qm74	4378	21	via	via	IN
cord-015021-pol2qm74	4378	22	analysis	analysis	NN
cord-015021-pol2qm74	4378	23	of	of	IN
cord-015021-pol2qm74	4378	24	the	the	DT
cord-015021-pol2qm74	4378	25	expression	expression	NN
cord-015021-pol2qm74	4378	26	of	of	IN
cord-015021-pol2qm74	4378	27	CD14	CD14	NNP
cord-015021-pol2qm74	4378	28	+	+	CC
cord-015021-pol2qm74	4378	29	receptor	receptor	NN
cord-015021-pol2qm74	4378	30	,	,	,
cord-015021-pol2qm74	4378	31	the	the	DT
cord-015021-pol2qm74	4378	32	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	4378	33	mediator	mediator	NN
cord-015021-pol2qm74	4378	34	IL-6	IL-6	NNP
cord-015021-pol2qm74	4378	35	,	,	,
cord-015021-pol2qm74	4378	36	the	the	DT
cord-015021-pol2qm74	4378	37	macrophage	macrophage	NN
cord-015021-pol2qm74	4378	38	activating	activate	VBG
cord-015021-pol2qm74	4378	39	factor	factor	NN
cord-015021-pol2qm74	4378	40	IFN-5	IFN-5	NNP
cord-015021-pol2qm74	4378	41	,	,	,
cord-015021-pol2qm74	4378	42	,	,	,
cord-015021-pol2qm74	4378	43	and	and	CC
cord-015021-pol2qm74	4378	44	Neopterin	Neopterin	NNP
cord-015021-pol2qm74	4378	45	(	(	-LRB-
cord-015021-pol2qm74	4378	46	NPT	NPT	NNP
cord-015021-pol2qm74	4378	47	)	)	-RRB-
cord-015021-pol2qm74	4378	48	a	a	DT
cord-015021-pol2qm74	4378	49	metabolite	metabolite	NN
cord-015021-pol2qm74	4378	50	of	of	IN
cord-015021-pol2qm74	4378	51	activated	activate	VBN
cord-015021-pol2qm74	4378	52	MO	MO	NNP
cord-015021-pol2qm74	4378	53	.	.	.
cord-015021-pol2qm74	4379	1	We	-PRON-	PRP
cord-015021-pol2qm74	4379	2	investigated	investigate	VBD
cord-015021-pol2qm74	4379	3	PBMC	PBMC	NNP
cord-015021-pol2qm74	4379	4	's	's	POS
cord-015021-pol2qm74	4379	5	on	on	IN
cord-015021-pol2qm74	4379	6	consecutive	consecutive	JJ
cord-015021-pol2qm74	4379	7	days	day	NNS
cord-015021-pol2qm74	4379	8	1	1	CD
cord-015021-pol2qm74	4379	9	,	,	,
cord-015021-pol2qm74	4379	10	3	3	CD
cord-015021-pol2qm74	4379	11	,	,	,
cord-015021-pol2qm74	4379	12	5	5	CD
cord-015021-pol2qm74	4379	13	,	,	,
cord-015021-pol2qm74	4379	14	7	7	CD
cord-015021-pol2qm74	4379	15	and	and	CC
cord-015021-pol2qm74	4379	16	10	10	CD
cord-015021-pol2qm74	4379	17	after	after	IN
cord-015021-pol2qm74	4379	18	mechanical	mechanical	JJ
cord-015021-pol2qm74	4379	19	trauma	trauma	NN
cord-015021-pol2qm74	4379	20	of	of	IN
cord-015021-pol2qm74	4379	21	9	9	CD
cord-015021-pol2qm74	4379	22	and	and	CC
cord-015021-pol2qm74	4379	23	after	after	IN
cord-015021-pol2qm74	4379	24	bum	bum	NN
cord-015021-pol2qm74	4379	25	trauma	trauma	NN
cord-015021-pol2qm74	4379	26	of	of	IN
cord-015021-pol2qm74	4379	27	5	5	CD
cord-015021-pol2qm74	4379	28	patients	patient	NNS
cord-015021-pol2qm74	4379	29	(	(	-LRB-
cord-015021-pol2qm74	4379	30	mean	mean	VB
cord-015021-pol2qm74	4379	31	age	age	NN
cord-015021-pol2qm74	4379	32	38~17	38~17	CD
cord-015021-pol2qm74	4379	33	years	year	NNS
cord-015021-pol2qm74	4379	34	;	;	:
cord-015021-pol2qm74	4379	35	mean	mean	VB
cord-015021-pol2qm74	4379	36	ISS	ISS	NNP
cord-015021-pol2qm74	4379	37	34±2	34±2	CD
cord-015021-pol2qm74	4379	38	pts	pts	NNP
cord-015021-pol2qm74	4379	39	)	)	-RRB-
cord-015021-pol2qm74	4379	40	.	.	.
cord-015021-pol2qm74	4380	1	In	in	IN
cord-015021-pol2qm74	4380	2	trauma	trauma	NN
cord-015021-pol2qm74	4380	3	patients	patient	NNS
cord-015021-pol2qm74	4380	4	we	-PRON-	PRP
cord-015021-pol2qm74	4380	5	saw	see	VBD
cord-015021-pol2qm74	4380	6	a	a	DT
cord-015021-pol2qm74	4380	7	massive	massive	JJ
cord-015021-pol2qm74	4380	8	increase	increase	NN
cord-015021-pol2qm74	4380	9	of	of	IN
cord-015021-pol2qm74	4380	10	PHA	PHA	NNP
cord-015021-pol2qm74	4380	11	induced	induce	VBN
cord-015021-pol2qm74	4380	12	neopterin	neopterin	JJ
cord-015021-pol2qm74	4380	13	synthesis	synthesis	NN
cord-015021-pol2qm74	4380	14	compared	compare	VBN
cord-015021-pol2qm74	4380	15	to	to	IN
cord-015021-pol2qm74	4380	16	controls	control	NNS
cord-015021-pol2qm74	4380	17	.	.	.
cord-015021-pol2qm74	4381	1	However	however	RB
cord-015021-pol2qm74	4381	2	,	,	,
cord-015021-pol2qm74	4381	3	when	when	WRB
cord-015021-pol2qm74	4381	4	discriminating	discriminate	VBG
cord-015021-pol2qm74	4381	5	the	the	DT
cord-015021-pol2qm74	4381	6	NPT	NPT	NNP
cord-015021-pol2qm74	4381	7	levels	level	NNS
cord-015021-pol2qm74	4381	8	in	in	IN
cord-015021-pol2qm74	4381	9	the	the	DT
cord-015021-pol2qm74	4381	10	supernatants	supernatant	NNS
cord-015021-pol2qm74	4381	11	for	for	IN
cord-015021-pol2qm74	4381	12	the	the	DT
cord-015021-pol2qm74	4381	13	amount	amount	NN
cord-015021-pol2qm74	4381	14	of	of	IN
cord-015021-pol2qm74	4381	15	MO	MO	NNP
cord-015021-pol2qm74	4381	16	stimulated	stimulate	VBN
cord-015021-pol2qm74	4381	17	,	,	,
cord-015021-pol2qm74	4381	18	the	the	DT
cord-015021-pol2qm74	4381	19	NPT	npt	NN
cord-015021-pol2qm74	4381	20	output	output	NN
cord-015021-pol2qm74	4381	21	of	of	IN
cord-015021-pol2qm74	4381	22	the	the	DT
cord-015021-pol2qm74	4381	23	individual	individual	JJ
cord-015021-pol2qm74	4381	24	cell	cell	NN
cord-015021-pol2qm74	4381	25	was	be	VBD
cord-015021-pol2qm74	4381	26	lower	low	JJR
cord-015021-pol2qm74	4381	27	compared	compare	VBN
cord-015021-pol2qm74	4381	28	to	to	IN
cord-015021-pol2qm74	4381	29	MO	MO	NNP
cord-015021-pol2qm74	4381	30	of	of	IN
cord-015021-pol2qm74	4381	31	nontraumatized	nontraumatize	VBN
cord-015021-pol2qm74	4381	32	individuals	individual	NNS
cord-015021-pol2qm74	4381	33	.	.	.
cord-015021-pol2qm74	4382	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	4382	2	there	there	EX
cord-015021-pol2qm74	4382	3	was	be	VBD
cord-015021-pol2qm74	4382	4	a	a	DT
cord-015021-pol2qm74	4382	5	contrary	contrary	NN
cord-015021-pol2qm74	4382	6	coarse	coarse	JJ
cord-015021-pol2qm74	4382	7	in	in	IN
cord-015021-pol2qm74	4382	8	the	the	DT
cord-015021-pol2qm74	4382	9	cumulative	cumulative	JJ
cord-015021-pol2qm74	4382	10	protein	protein	NN
cord-015021-pol2qm74	4382	11	release	release	NN
cord-015021-pol2qm74	4382	12	patterns	pattern	NNS
cord-015021-pol2qm74	4382	13	of	of	IN
cord-015021-pol2qm74	4383	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	4383	2	and	and	CC
cord-015021-pol2qm74	4383	3	IFN-7	IFN-7	NNP
cord-015021-pol2qm74	4383	4	in	in	IN
cord-015021-pol2qm74	4383	5	mechanical	mechanical	JJ
cord-015021-pol2qm74	4383	6	versus	versus	IN
cord-015021-pol2qm74	4383	7	burn	burn	NN
cord-015021-pol2qm74	4383	8	trauma	trauma	NN
cord-015021-pol2qm74	4383	9	patients	patient	NNS
cord-015021-pol2qm74	4383	10	.	.	.
cord-015021-pol2qm74	4384	1	Wheras	Wheras	NNP
cord-015021-pol2qm74	4384	2	in	in	IN
cord-015021-pol2qm74	4384	3	burn	burn	NN
cord-015021-pol2qm74	4384	4	patients	patient	NNS
cord-015021-pol2qm74	4384	5	IFN	IFN	NNP
cord-015021-pol2qm74	4384	6	-	-	HYPH
cord-015021-pol2qm74	4384	7	y	y	NNP
cord-015021-pol2qm74	4384	8	was	be	VBD
cord-015021-pol2qm74	4384	9	decreased	decrease	VBN
cord-015021-pol2qm74	4384	10	significantly	significantly	RB
cord-015021-pol2qm74	4384	11	(	(	-LRB-
cord-015021-pol2qm74	4384	12	16	16	CD
cord-015021-pol2qm74	4384	13	+	+	SYM
cord-015021-pol2qm74	4384	14	5	5	CD
cord-015021-pol2qm74	4384	15	U	u	NN
cord-015021-pol2qm74	4384	16	/	/	SYM
cord-015021-pol2qm74	4384	17	ml	ml	NN
cord-015021-pol2qm74	4384	18	)	)	-RRB-
cord-015021-pol2qm74	4384	19	compared	compare	VBN
cord-015021-pol2qm74	4384	20	to	to	IN
cord-015021-pol2qm74	4384	21	controls	control	NNS
cord-015021-pol2qm74	4384	22	(	(	-LRB-
cord-015021-pol2qm74	4384	23	58	58	CD
cord-015021-pol2qm74	4384	24	+	+	SYM
cord-015021-pol2qm74	4384	25	6	6	CD
cord-015021-pol2qm74	4384	26	U	u	NN
cord-015021-pol2qm74	4384	27	/	/	SYM
cord-015021-pol2qm74	4384	28	ml	ml	NN
cord-015021-pol2qm74	4384	29	)	)	-RRB-
cord-015021-pol2qm74	4384	30	as	as	RB
cord-015021-pol2qm74	4384	31	well	well	RB
cord-015021-pol2qm74	4384	32	as	as	IN
cord-015021-pol2qm74	4384	33	mechanical	mechanical	JJ
cord-015021-pol2qm74	4384	34	trauma	trauma	NN
cord-015021-pol2qm74	4384	35	(	(	-LRB-
cord-015021-pol2qm74	4384	36	59	59	CD
cord-015021-pol2qm74	4384	37	+	+	SYM
cord-015021-pol2qm74	4384	38	12	12	CD
cord-015021-pol2qm74	4384	39	U	u	NN
cord-015021-pol2qm74	4384	40	/	/	SYM
cord-015021-pol2qm74	4384	41	ml	ml	NN
cord-015021-pol2qm74	4384	42	)	)	-RRB-
cord-015021-pol2qm74	4384	43	.	.	.
cord-015021-pol2qm74	4385	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	4385	2	showed	show	VBD
cord-015021-pol2qm74	4385	3	a	a	DT
cord-015021-pol2qm74	4385	4	significant	significant	JJ
cord-015021-pol2qm74	4385	5	suppression	suppression	NN
cord-015021-pol2qm74	4385	6	following	follow	VBG
cord-015021-pol2qm74	4385	7	mechanical	mechanical	JJ
cord-015021-pol2qm74	4385	8	trauma	trauma	NN
cord-015021-pol2qm74	4385	9	(	(	-LRB-
cord-015021-pol2qm74	4385	10	662	662	CD
cord-015021-pol2qm74	4385	11	+	+	SYM
cord-015021-pol2qm74	4385	12	58	58	CD
cord-015021-pol2qm74	4385	13	U	u	NN
cord-015021-pol2qm74	4385	14	/	/	SYM
cord-015021-pol2qm74	4385	15	ml	ml	NN
cord-015021-pol2qm74	4385	16	)	)	-RRB-
cord-015021-pol2qm74	4385	17	vs	vs	IN
cord-015021-pol2qm74	4385	18	control	control	NN
cord-015021-pol2qm74	4385	19	(	(	-LRB-
cord-015021-pol2qm74	4385	20	1266	1266	CD
cord-015021-pol2qm74	4385	21	+	+	SYM
cord-015021-pol2qm74	4385	22	91	91	CD
cord-015021-pol2qm74	4385	23	U	u	NN
cord-015021-pol2qm74	4385	24	/	/	SYM
cord-015021-pol2qm74	4385	25	ml	ml	NN
cord-015021-pol2qm74	4385	26	)	)	-RRB-
cord-015021-pol2qm74	4385	27	and	and	CC
cord-015021-pol2qm74	4385	28	bum	bum	JJ
cord-015021-pol2qm74	4385	29	patients	patient	NNS
cord-015021-pol2qm74	4385	30	.	.	.
cord-015021-pol2qm74	4386	1	The	the	DT
cord-015021-pol2qm74	4386	2	rt~,NA	rt~,na	CD
cord-015021-pol2qm74	4386	3	signal	signal	NN
cord-015021-pol2qm74	4386	4	intensity	intensity	NN
cord-015021-pol2qm74	4386	5	for	for	IN
cord-015021-pol2qm74	4386	6	beth	beth	NNP
cord-015021-pol2qm74	4386	7	eytokines	eytokines	NNP
cord-015021-pol2qm74	4386	8	was	be	VBD
cord-015021-pol2qm74	4386	9	in	in	IN
cord-015021-pol2qm74	4386	10	concurrence	concurrence	NN
cord-015021-pol2qm74	4386	11	with	with	IN
cord-015021-pol2qm74	4386	12	the	the	DT
cord-015021-pol2qm74	4386	13	protein	protein	NN
cord-015021-pol2qm74	4386	14	release	release	NN
cord-015021-pol2qm74	4386	15	in	in	IN
cord-015021-pol2qm74	4386	16	more	more	JJR
cord-015021-pol2qm74	4386	17	than	than	IN
cord-015021-pol2qm74	4386	18	85	85	CD
cord-015021-pol2qm74	4386	19	%	%	NN
cord-015021-pol2qm74	4386	20	of	of	IN
cord-015021-pol2qm74	4386	21	the	the	DT
cord-015021-pol2qm74	4386	22	individual	individual	JJ
cord-015021-pol2qm74	4386	23	patients	patient	NNS
cord-015021-pol2qm74	4386	24	investigated	investigate	VBN
cord-015021-pol2qm74	4386	25	.	.	.
cord-015021-pol2qm74	4387	1	From	from	IN
cord-015021-pol2qm74	4387	2	these	these	DT
cord-015021-pol2qm74	4387	3	data	datum	NNS
cord-015021-pol2qm74	4387	4	we	-PRON-	PRP
cord-015021-pol2qm74	4387	5	can	can	MD
cord-015021-pol2qm74	4387	6	conclude	conclude	VB
cord-015021-pol2qm74	4387	7	that	that	IN
cord-015021-pol2qm74	4387	8	the	the	DT
cord-015021-pol2qm74	4387	9	inadequate	inadequate	JJ
cord-015021-pol2qm74	4387	10	low	low	JJ
cord-015021-pol2qm74	4387	11	NPT	npt	NN
cord-015021-pol2qm74	4387	12	synthesis	synthesis	NN
cord-015021-pol2qm74	4387	13	predominantly	predominantly	RB
cord-015021-pol2qm74	4387	14	in	in	IN
cord-015021-pol2qm74	4387	15	bum	bum	JJ
cord-015021-pol2qm74	4387	16	patients	patient	NNS
cord-015021-pol2qm74	4387	17	appears	appear	VBZ
cord-015021-pol2qm74	4387	18	to	to	TO
cord-015021-pol2qm74	4387	19	be	be	VB
cord-015021-pol2qm74	4387	20	a	a	DT
cord-015021-pol2qm74	4387	21	sign	sign	NN
cord-015021-pol2qm74	4387	22	of	of	IN
cord-015021-pol2qm74	4387	23	cellular	cellular	JJ
cord-015021-pol2qm74	4387	24	immaturity	immaturity	NN
cord-015021-pol2qm74	4387	25	and	and	CC
cord-015021-pol2qm74	4387	26	is	be	VBZ
cord-015021-pol2qm74	4387	27	probably	probably	RB
cord-015021-pol2qm74	4387	28	partly	partly	RB
cord-015021-pol2qm74	4387	29	due	due	JJ
cord-015021-pol2qm74	4387	30	to	to	IN
cord-015021-pol2qm74	4387	31	low	low	JJ
cord-015021-pol2qm74	4387	32	T	t	NN
cord-015021-pol2qm74	4387	33	-	-	HYPH
cord-015021-pol2qm74	4387	34	cell	cell	NN
cord-015021-pol2qm74	4387	35	IFNo	IFNo	NNS
cord-015021-pol2qm74	4387	36	T	t	NN
cord-015021-pol2qm74	4387	37	signals	signal	NNS
cord-015021-pol2qm74	4387	38	.	.	.
cord-015021-pol2qm74	4388	1	In	in	IN
cord-015021-pol2qm74	4388	2	addition	addition	NN
cord-015021-pol2qm74	4388	3	we	-PRON-	PRP
cord-015021-pol2qm74	4388	4	could	could	MD
cord-015021-pol2qm74	4388	5	state	state	VB
cord-015021-pol2qm74	4388	6	that	that	IN
cord-015021-pol2qm74	4388	7	the	the	DT
cord-015021-pol2qm74	4388	8	quality	quality	NN
cord-015021-pol2qm74	4388	9	of	of	IN
cord-015021-pol2qm74	4388	10	trauma	trauma	NN
cord-015021-pol2qm74	4388	11	is	be	VBZ
cord-015021-pol2qm74	4388	12	apparently	apparently	RB
cord-015021-pol2qm74	4388	13	responsible	responsible	JJ
cord-015021-pol2qm74	4388	14	for	for	IN
cord-015021-pol2qm74	4388	15	the	the	DT
cord-015021-pol2qm74	4388	16	different	different	JJ
cord-015021-pol2qm74	4388	17	synthesis	synthesis	NN
cord-015021-pol2qm74	4388	18	patterns	pattern	NNS
cord-015021-pol2qm74	4388	19	of	of	IN
cord-015021-pol2qm74	4388	20	]	]	-RRB-
cord-015021-pol2qm74	4388	21	L-6	L-6	NNP
cord-015021-pol2qm74	4388	22	and	and	CC
cord-015021-pol2qm74	4388	23	IFN	IFN	NNP
cord-015021-pol2qm74	4388	24	-	-	HYPH
cord-015021-pol2qm74	4388	25	q	q	NNP
cord-015021-pol2qm74	4388	26	,	,	,
cord-015021-pol2qm74	4388	27	.	.	.
cord-015021-pol2qm74	4389	1	It	-PRON-	PRP
cord-015021-pol2qm74	4389	2	has	have	VBZ
cord-015021-pol2qm74	4389	3	been	be	VBN
cord-015021-pol2qm74	4389	4	postulated	postulate	VBN
cord-015021-pol2qm74	4389	5	that	that	IN
cord-015021-pol2qm74	4389	6	bacterial	bacterial	JJ
cord-015021-pol2qm74	4389	7	invasion	invasion	NN
cord-015021-pol2qm74	4389	8	or	or	CC
cord-015021-pol2qm74	4389	9	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4389	10	are	be	VBP
cord-015021-pol2qm74	4389	11	necessary	necessary	JJ
cord-015021-pol2qm74	4389	12	for	for	IN
cord-015021-pol2qm74	4389	13	cytokine	cytokine	NN
cord-015021-pol2qm74	4389	14	production	production	NN
cord-015021-pol2qm74	4389	15	following	follow	VBG
cord-015021-pol2qm74	4389	16	burn	burn	NN
cord-015021-pol2qm74	4389	17	injury	injury	NN
cord-015021-pol2qm74	4389	18	.	.	.
cord-015021-pol2qm74	4390	1	We	-PRON-	PRP
cord-015021-pol2qm74	4390	2	studied	study	VBD
cord-015021-pol2qm74	4390	3	the	the	DT
cord-015021-pol2qm74	4390	4	organ	organ	NN
cord-015021-pol2qm74	4390	5	distribution	distribution	NN
cord-015021-pol2qm74	4390	6	and	and	CC
cord-015021-pol2qm74	4390	7	kinetics	kinetics	NN
cord-015021-pol2qm74	4390	8	pattern	pattern	NN
cord-015021-pol2qm74	4390	9	of	of	IN
cord-015021-pol2qm74	4390	10	IL	IL	NNP
cord-015021-pol2qm74	4390	11	-	-	HYPH
cord-015021-pol2qm74	4390	12	fc~	fc~	NN
cord-015021-pol2qm74	4390	13	(	(	-LRB-
cord-015021-pol2qm74	4390	14	cell	cell	NN
cord-015021-pol2qm74	4390	15	-	-	HYPH
cord-015021-pol2qm74	4390	16	associated	associate	VBN
cord-015021-pol2qm74	4390	17	IL-1	IL-1	NNP
cord-015021-pol2qm74	4390	18	agonist	agonist	NN
cord-015021-pol2qm74	4390	19	)	)	-RRB-
cord-015021-pol2qm74	4390	20	in	in	IN
cord-015021-pol2qm74	4390	21	eutrophic	eutrophic	JJ
cord-015021-pol2qm74	4390	22	rats	rat	NNS
cord-015021-pol2qm74	4390	23	subjected	subject	VBN
cord-015021-pol2qm74	4390	24	to	to	IN
cord-015021-pol2qm74	4390	25	either	either	CC
cord-015021-pol2qm74	4390	26	20	20	CD
cord-015021-pol2qm74	4390	27	%	%	NN
cord-015021-pol2qm74	4390	28	TBSA	TBSA	NNP
cord-015021-pol2qm74	4390	29	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	4390	30	scald	scald	NN
cord-015021-pol2qm74	4390	31	injury	injury	NN
cord-015021-pol2qm74	4390	32	(	(	-LRB-
cord-015021-pol2qm74	4390	33	BI	BI	NNP
cord-015021-pol2qm74	4390	34	)	)	-RRB-
cord-015021-pol2qm74	4390	35	,	,	,
cord-015021-pol2qm74	4390	36	muscle	muscle	NN
cord-015021-pol2qm74	4390	37	scald	scald	NN
cord-015021-pol2qm74	4390	38	injury	injury	NN
cord-015021-pol2qm74	4390	39	of	of	IN
cord-015021-pol2qm74	4390	40	equivalent	equivalent	JJ
cord-015021-pol2qm74	4390	41	20	20	CD
cord-015021-pol2qm74	4390	42	%	%	NN
cord-015021-pol2qm74	4390	43	TBSA	TBSA	NNP
cord-015021-pol2qm74	4390	44	(	(	-LRB-
cord-015021-pol2qm74	4390	45	MBI	MBI	NNP
cord-015021-pol2qm74	4390	46	)	)	-RRB-
cord-015021-pol2qm74	4390	47	,	,	,
cord-015021-pol2qm74	4390	48	sham	sham	NN
cord-015021-pol2qm74	4390	49	muscle	muscle	NN
cord-015021-pol2qm74	4390	50	bum	bum	NN
cord-015021-pol2qm74	4390	51	(	(	-LRB-
cord-015021-pol2qm74	4390	52	resection	resection	NN
cord-015021-pol2qm74	4390	53	of	of	IN
cord-015021-pol2qm74	4390	54	skin	skin	NN
cord-015021-pol2qm74	4390	55	only	only	RB
cord-015021-pol2qm74	4390	56	,	,	,
cord-015021-pol2qm74	4390	57	up	up	IN
cord-015021-pol2qm74	4390	58	to	to	TO
cord-015021-pol2qm74	4390	59	20	20	CD
cord-015021-pol2qm74	4390	60	%	%	NN
cord-015021-pol2qm74	4390	61	TBSA	TBSA	NNP
cord-015021-pol2qm74	4390	62	)	)	-RRB-
cord-015021-pol2qm74	4390	63	(	(	-LRB-
cord-015021-pol2qm74	4390	64	SMBI	SMBI	NNP
cord-015021-pol2qm74	4390	65	)	)	-RRB-
cord-015021-pol2qm74	4390	66	,	,	,
cord-015021-pol2qm74	4390	67	and	and	CC
cord-015021-pol2qm74	4390	68	sham	sham	JJ
cord-015021-pol2qm74	4390	69	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	4390	70	burn	burn	NN
cord-015021-pol2qm74	4390	71	(	(	-LRB-
cord-015021-pol2qm74	4390	72	SBI	SBI	NNP
cord-015021-pol2qm74	4390	73	)	)	-RRB-
cord-015021-pol2qm74	4390	74	,	,	,
cord-015021-pol2qm74	4390	75	followed	follow	VBN
cord-015021-pol2qm74	4390	76	by	by	IN
cord-015021-pol2qm74	4390	77	saline	saline	NN
cord-015021-pol2qm74	4390	78	resuscitation	resuscitation	NN
cord-015021-pol2qm74	4390	79	(	(	-LRB-
cord-015021-pol2qm74	4390	80	15	15	CD
cord-015021-pol2qm74	4390	81	mUkg	mUkg	NNP
cord-015021-pol2qm74	4390	82	I.P.	I.P.	NNP
cord-015021-pol2qm74	4390	83	)	)	-RRB-
cord-015021-pol2qm74	4390	84	.	.	.
cord-015021-pol2qm74	4391	1	Separate	separate	JJ
cord-015021-pol2qm74	4391	2	rats	rat	NNS
cord-015021-pol2qm74	4391	3	were	be	VBD
cord-015021-pol2qm74	4391	4	infused	infuse	VBN
cord-015021-pol2qm74	4391	5	with	with	IN
cord-015021-pol2qm74	4391	6	15	15	CD
cord-015021-pol2qm74	4391	7	mg	mg	NNP
cord-015021-pol2qm74	4391	8	/	/	SYM
cord-015021-pol2qm74	4391	9	kg	kg	NNP
cord-015021-pol2qm74	4391	10	E.coli	E.coli	NNS
cord-015021-pol2qm74	4391	11	0111	0111	CD
cord-015021-pol2qm74	4391	12	:	:	:
cord-015021-pol2qm74	4391	13	B4	B4	NNP
cord-015021-pol2qm74	4391	14	LPS	LPS	NNP
cord-015021-pol2qm74	4391	15	or	or	CC
cord-015021-pol2qm74	4391	16	saline	saline	NN
cord-015021-pol2qm74	4391	17	LV	LV	NNP
cord-015021-pol2qm74	4391	18	.	.	.
cord-015021-pol2qm74	4392	1	Unmanipulated	unmanipulated	JJ
cord-015021-pol2qm74	4392	2	rats	rat	NNS
cord-015021-pol2qm74	4392	3	were	be	VBD
cord-015021-pol2qm74	4392	4	baseline	baseline	JJ
cord-015021-pol2qm74	4392	5	normal	normal	JJ
cord-015021-pol2qm74	4392	6	controls	control	NNS
cord-015021-pol2qm74	4392	7	.	.	.
cord-015021-pol2qm74	4393	1	Liver	liver	NN
cord-015021-pol2qm74	4393	2	,	,	,
cord-015021-pol2qm74	4393	3	lung	lung	NN
cord-015021-pol2qm74	4393	4	,	,	,
cord-015021-pol2qm74	4393	5	spleen	spleen	NNS
cord-015021-pol2qm74	4393	6	,	,	,
cord-015021-pol2qm74	4393	7	ileum	ileum	NN
cord-015021-pol2qm74	4393	8	,	,	,
cord-015021-pol2qm74	4393	9	thymus	thymus	NN
cord-015021-pol2qm74	4393	10	,	,	,
cord-015021-pol2qm74	4393	11	kidney	kidney	NN
cord-015021-pol2qm74	4393	12	,	,	,
cord-015021-pol2qm74	4393	13	skin	skin	NN
cord-015021-pol2qm74	4393	14	,	,	,
cord-015021-pol2qm74	4393	15	and	and	CC
cord-015021-pol2qm74	4393	16	plasma	plasma	NN
cord-015021-pol2qm74	4393	17	were	be	VBD
cord-015021-pol2qm74	4393	18	harvested	harvest	VBN
cord-015021-pol2qm74	4393	19	at	at	IN
cord-015021-pol2qm74	4393	20	various	various	JJ
cord-015021-pol2qm74	4393	21	time	time	NN
cord-015021-pol2qm74	4393	22	-	-	HYPH
cord-015021-pol2qm74	4393	23	points	point	NNS
cord-015021-pol2qm74	4393	24	within	within	IN
cord-015021-pol2qm74	4393	25	the	the	DT
cord-015021-pol2qm74	4393	26	first	first	JJ
cord-015021-pol2qm74	4393	27	24h	24h	NNS
cord-015021-pol2qm74	4393	28	.	.	.
cord-015021-pol2qm74	4394	1	Tissues	tissue	NNS
cord-015021-pol2qm74	4394	2	were	be	VBD
cord-015021-pol2qm74	4394	3	frozen	freeze	VBN
cord-015021-pol2qm74	4394	4	,	,	,
cord-015021-pol2qm74	4394	5	weighed	weigh	VBN
cord-015021-pol2qm74	4394	6	,	,	,
cord-015021-pol2qm74	4394	7	homogenized	homogenize	VBN
cord-015021-pol2qm74	4394	8	,	,	,
cord-015021-pol2qm74	4394	9	the	the	DT
cord-015021-pol2qm74	4394	10	homogenates	homogenate	NNS
cord-015021-pol2qm74	4394	11	centrifuged	centrifuge	VBN
cord-015021-pol2qm74	4394	12	and	and	CC
cord-015021-pol2qm74	4394	13	the	the	DT
cord-015021-pol2qm74	4394	14	supernates	supernate	NNS
cord-015021-pol2qm74	4394	15	assayed	assay	VBN
cord-015021-pol2qm74	4394	16	with	with	IN
cord-015021-pol2qm74	4394	17	a	a	DT
cord-015021-pol2qm74	4394	18	radioimmunoassay	radioimmunoassay	JJ
cord-015021-pol2qm74	4394	19	specific	specific	JJ
cord-015021-pol2qm74	4394	20	for	for	IN
cord-015021-pol2qm74	4394	21	rat	rat	NN
cord-015021-pol2qm74	4394	22	IL	IL	NNP
cord-015021-pol2qm74	4394	23	-	-	HYPH
cord-015021-pol2qm74	4394	24	l(z	l(z	NNP
cord-015021-pol2qm74	4394	25	(	(	-LRB-
cord-015021-pol2qm74	4394	26	detection	detection	NN
cord-015021-pol2qm74	4394	27	limit	limit	NN
cord-015021-pol2qm74	4394	28	150	150	CD
cord-015021-pol2qm74	4394	29	pg	pg	NN
cord-015021-pol2qm74	4394	30	/	/	SYM
cord-015021-pol2qm74	4394	31	rnL	rnL	NNP
cord-015021-pol2qm74	4394	32	)	)	-RRB-
cord-015021-pol2qm74	4394	33	.	.	.
cord-015021-pol2qm74	4395	1	IL	IL	NNP
cord-015021-pol2qm74	4395	2	-	-	HYPH
cord-015021-pol2qm74	4395	3	lc~	lc~	NNP
cord-015021-pol2qm74	4395	4	was	be	VBD
cord-015021-pol2qm74	4395	5	expressed	express	VBN
cord-015021-pol2qm74	4395	6	as	as	IN
cord-015021-pol2qm74	4395	7	ng	ng	NNP
cord-015021-pol2qm74	4395	8	/	/	SYM
cord-015021-pol2qm74	4395	9	g	g	NN
cord-015021-pol2qm74	4395	10	weight	weight	NN
cord-015021-pol2qm74	4395	11	+	+	CC
cord-015021-pol2qm74	4395	12	SEM	sem	NN
cord-015021-pol2qm74	4395	13	(	(	-LRB-
cord-015021-pol2qm74	4395	14	lowest	low	JJS
cord-015021-pol2qm74	4395	15	detectable	detectable	JJ
cord-015021-pol2qm74	4395	16	amount	amount	NN
cord-015021-pol2qm74	4395	17	1.5	1.5	CD
cord-015021-pol2qm74	4395	18	ng	ng	NN
cord-015021-pol2qm74	4395	19	/	/	SYM
cord-015021-pol2qm74	4395	20	gWT	gWT	NNP
cord-015021-pol2qm74	4395	21	)	)	-RRB-
cord-015021-pol2qm74	4395	22	.	.	.
cord-015021-pol2qm74	4396	1	IL	IL	NNP
cord-015021-pol2qm74	4396	2	-	-	HYPH
cord-015021-pol2qm74	4396	3	lo~	lo~	NNP
cord-015021-pol2qm74	4396	4	was	be	VBD
cord-015021-pol2qm74	4396	5	constitutively	constitutively	RB
cord-015021-pol2qm74	4396	6	present	present	JJ
cord-015021-pol2qm74	4396	7	only	only	RB
cord-015021-pol2qm74	4396	8	in	in	IN
cord-015021-pol2qm74	4396	9	the	the	DT
cord-015021-pol2qm74	4396	10	skin	skin	NN
cord-015021-pol2qm74	4396	11	(	(	-LRB-
cord-015021-pol2qm74	4396	12	102	102	CD
cord-015021-pol2qm74	4396	13	+	+	SYM
cord-015021-pol2qm74	4396	14	16.4	16.4	CD
cord-015021-pol2qm74	4396	15	ng	ng	NN
cord-015021-pol2qm74	4396	16	/	/	SYM
cord-015021-pol2qm74	4396	17	gWT	gWT	NNP
cord-015021-pol2qm74	4396	18	)	)	-RRB-
cord-015021-pol2qm74	4396	19	.	.	.
cord-015021-pol2qm74	4397	1	Cutaneous	cutaneous	JJ
cord-015021-pol2qm74	4397	2	burn	burn	NN
cord-015021-pol2qm74	4397	3	and	and	CC
cord-015021-pol2qm74	4397	4	sham	sham	JJ
cord-015021-pol2qm74	4397	5	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	4397	6	bum	bum	NN
cord-015021-pol2qm74	4397	7	induced	induce	VBN
cord-015021-pol2qm74	4397	8	biphasic	biphasic	JJ
cord-015021-pol2qm74	4397	9	elevations	elevation	NNS
cord-015021-pol2qm74	4397	10	of	of	IN
cord-015021-pol2qm74	4397	11	IL	IL	NNP
cord-015021-pol2qm74	4397	12	-	-	HYPH
cord-015021-pol2qm74	4397	13	lcc	lcc	NNP
cord-015021-pol2qm74	4397	14	in	in	IN
cord-015021-pol2qm74	4397	15	the	the	DT
cord-015021-pol2qm74	4397	16	liver	liver	NN
cord-015021-pol2qm74	4397	17	and	and	CC
cord-015021-pol2qm74	4397	18	lung	lung	NN
cord-015021-pol2qm74	4397	19	only	only	RB
cord-015021-pol2qm74	4397	20	,	,	,
cord-015021-pol2qm74	4397	21	with	with	IN
cord-015021-pol2qm74	4397	22	maximal	maximal	JJ
cord-015021-pol2qm74	4397	23	levels	level	NNS
cord-015021-pol2qm74	4397	24	at	at	IN
cord-015021-pol2qm74	4397	25	2.5h	2.5h	CD
cord-015021-pol2qm74	4397	26	(	(	-LRB-
cord-015021-pol2qm74	4397	27	in	in	IN
cord-015021-pol2qm74	4397	28	the	the	DT
cord-015021-pol2qm74	4397	29	liver	liver	NN
cord-015021-pol2qm74	4397	30	,	,	,
cord-015021-pol2qm74	4397	31	BI	BI	NNP
cord-015021-pol2qm74	4397	32	=	=	NFP
cord-015021-pol2qm74	4398	1	16.5	16.5	NNP
cord-015021-pol2qm74	4398	2	_	_	NNP
cord-015021-pol2qm74	4398	3	+	+	SYM
cord-015021-pol2qm74	4398	4	6.2	6.2	CD
cord-015021-pol2qm74	4398	5	ng	ng	NN
cord-015021-pol2qm74	4398	6	/	/	SYM
cord-015021-pol2qm74	4398	7	gWT	gWT	NNS
cord-015021-pol2qm74	4398	8	,	,	,
cord-015021-pol2qm74	4398	9	SBI	SBI	NNP
cord-015021-pol2qm74	4398	10	=	=	SYM
cord-015021-pol2qm74	4399	1	1.7	1.7	CD
cord-015021-pol2qm74	4399	2	+	+	SYM
cord-015021-pol2qm74	4399	3	0.1	0.1	CD
cord-015021-pol2qm74	4399	4	ng	ng	NN
cord-015021-pol2qm74	4399	5	/	/	SYM
cord-015021-pol2qm74	4399	6	gWT	gWT	NNS
cord-015021-pol2qm74	4399	7	,	,	,
cord-015021-pol2qm74	4399	8	p	p	NN
cord-015021-pol2qm74	4399	9	_	_	NN
cord-015021-pol2qm74	4399	10	<	<	XX
cord-015021-pol2qm74	4399	11	0.05	0.05	CD
cord-015021-pol2qm74	4399	12	;	;	:
cord-015021-pol2qm74	4399	13	in	in	IN
cord-015021-pol2qm74	4399	14	the	the	DT
cord-015021-pol2qm74	4399	15	lung	lung	NN
cord-015021-pol2qm74	4399	16	,	,	,
cord-015021-pol2qm74	4399	17	BI	BI	NNP
cord-015021-pol2qm74	4399	18	=	=	SYM
cord-015021-pol2qm74	4399	19	10.3	10.3	CD
cord-015021-pol2qm74	4399	20	+	+	SYM
cord-015021-pol2qm74	4399	21	1.3	1.3	CD
cord-015021-pol2qm74	4399	22	ng	ng	NN
cord-015021-pol2qm74	4399	23	/	/	SYM
cord-015021-pol2qm74	4399	24	gWT	gWT	NNS
cord-015021-pol2qm74	4399	25	,	,	,
cord-015021-pol2qm74	4399	26	SBI	SBI	NNP
cord-015021-pol2qm74	4399	27	=	=	SYM
cord-015021-pol2qm74	4399	28	1.9	1.9	CD
cord-015021-pol2qm74	4399	29	+	+	SYM
cord-015021-pol2qm74	4399	30	0.8	0.8	CD
cord-015021-pol2qm74	4399	31	ng	ng	NN
cord-015021-pol2qm74	4399	32	/	/	SYM
cord-015021-pol2qm74	4399	33	gWT	gWT	NNS
cord-015021-pol2qm74	4399	34	,	,	,
cord-015021-pol2qm74	4399	35	p	p	NN
cord-015021-pol2qm74	4399	36	-	-	HYPH
cord-015021-pol2qm74	4399	37	<	<	XX
cord-015021-pol2qm74	4399	38	0.002	0.002	CD
cord-015021-pol2qm74	4399	39	)	)	-RRB-
cord-015021-pol2qm74	4399	40	.	.	.
cord-015021-pol2qm74	4400	1	Of	of	IN
cord-015021-pol2qm74	4400	2	note	note	NN
cord-015021-pol2qm74	4400	3	,	,	,
cord-015021-pol2qm74	4400	4	both	both	CC
cord-015021-pol2qm74	4400	5	BI	BI	NNP
cord-015021-pol2qm74	4400	6	and	and	CC
cord-015021-pol2qm74	4400	7	SBI	SBI	NNP
cord-015021-pol2qm74	4400	8	rats	rat	NNS
cord-015021-pol2qm74	4400	9	had	have	VBD
cord-015021-pol2qm74	4400	10	detectable	detectable	JJ
cord-015021-pol2qm74	4400	11	IL	IL	NNP
cord-015021-pol2qm74	4400	12	-	-	HYPH
cord-015021-pol2qm74	4400	13	I~	I~	NNP
cord-015021-pol2qm74	4400	14	in	in	IN
cord-015021-pol2qm74	4400	15	the	the	DT
cord-015021-pol2qm74	4400	16	liver	liver	NN
cord-015021-pol2qm74	4400	17	at	at	IN
cord-015021-pol2qm74	4400	18	timepoint	timepoint	NN
cord-015021-pol2qm74	4400	19	0	0	NFP
cord-015021-pol2qm74	4400	20	already	already	RB
cord-015021-pol2qm74	4400	21	(	(	-LRB-
cord-015021-pol2qm74	4400	22	2	2	CD
cord-015021-pol2qm74	4400	23	min	min	NN
cord-015021-pol2qm74	4400	24	real	real	JJ
cord-015021-pol2qm74	4400	25	-	-	HYPH
cord-015021-pol2qm74	4400	26	time	time	NN
cord-015021-pol2qm74	4400	27	)	)	-RRB-
cord-015021-pol2qm74	4400	28	.	.	.
cord-015021-pol2qm74	4401	1	These	these	DT
cord-015021-pol2qm74	4401	2	levels	level	NNS
cord-015021-pol2qm74	4401	3	increased	increase	VBD
cord-015021-pol2qm74	4401	4	in	in	IN
cord-015021-pol2qm74	4401	5	parallel	parallel	NN
cord-015021-pol2qm74	4401	6	until	until	IN
cord-015021-pol2qm74	4401	7	30	30	CD
cord-015021-pol2qm74	4401	8	min	min	NN
cord-015021-pol2qm74	4401	9	and	and	CC
cord-015021-pol2qm74	4401	10	became	become	VBD
cord-015021-pol2qm74	4401	11	eventually	eventually	RB
cord-015021-pol2qm74	4401	12	different	different	JJ
cord-015021-pol2qm74	4401	13	by	by	IN
cord-015021-pol2qm74	4401	14	1	1	CD
cord-015021-pol2qm74	4401	15	log	log	NN
cord-015021-pol2qm74	4401	16	at	at	IN
cord-015021-pol2qm74	4401	17	1	1	CD
cord-015021-pol2qm74	4401	18	-2.5h	-2.5h	NN
cord-015021-pol2qm74	4401	19	.	.	.
cord-015021-pol2qm74	4402	1	All	all	DT
cord-015021-pol2qm74	4402	2	other	other	JJ
cord-015021-pol2qm74	4402	3	organs	organ	NNS
cord-015021-pol2qm74	4402	4	as	as	RB
cord-015021-pol2qm74	4402	5	well	well	RB
cord-015021-pol2qm74	4402	6	as	as	IN
cord-015021-pol2qm74	4402	7	plasma	plasma	NN
cord-015021-pol2qm74	4402	8	were	be	VBD
cord-015021-pol2qm74	4402	9	below	below	IN
cord-015021-pol2qm74	4402	10	detection	detection	NN
cord-015021-pol2qm74	4402	11	limits	limit	NNS
cord-015021-pol2qm74	4402	12	.	.	.
cord-015021-pol2qm74	4403	1	Muscle	muscle	NN
cord-015021-pol2qm74	4403	2	burn	burn	VBP
cord-015021-pol2qm74	4403	3	injury	injury	NN
cord-015021-pol2qm74	4403	4	and	and	CC
cord-015021-pol2qm74	4403	5	sham	sham	NN
cord-015021-pol2qm74	4403	6	muscle	muscle	NN
cord-015021-pol2qm74	4403	7	burn	burn	NN
cord-015021-pol2qm74	4403	8	(	(	-LRB-
cord-015021-pol2qm74	4403	9	skin	skin	NN
cord-015021-pol2qm74	4403	10	resection	resection	NN
cord-015021-pol2qm74	4403	11	)	)	-RRB-
cord-015021-pol2qm74	4403	12	induced	induce	VBN
cord-015021-pol2qm74	4403	13	similar	similar	JJ
cord-015021-pol2qm74	4403	14	elevations	elevation	NNS
cord-015021-pol2qm74	4403	15	of	of	IN
cord-015021-pol2qm74	4403	16	IL-10~	il-10~	NN
cord-015021-pol2qm74	4403	17	in	in	IN
cord-015021-pol2qm74	4403	18	the	the	DT
cord-015021-pol2qm74	4403	19	liver	liver	NN
cord-015021-pol2qm74	4403	20	at	at	IN
cord-015021-pol2qm74	4403	21	lh	lh	NNP
cord-015021-pol2qm74	4403	22	,	,	,
cord-015021-pol2qm74	4403	23	indistinguishable	indistinguishable	JJ
cord-015021-pol2qm74	4403	24	from	from	IN
cord-015021-pol2qm74	4403	25	each	each	DT
cord-015021-pol2qm74	4403	26	other	other	JJ
cord-015021-pol2qm74	4403	27	and	and	CC
cord-015021-pol2qm74	4403	28	from	from	IN
cord-015021-pol2qm74	4403	29	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	4403	30	burn	burn	NN
cord-015021-pol2qm74	4403	31	.	.	.
cord-015021-pol2qm74	4404	1	In	in	IN
cord-015021-pol2qm74	4404	2	contrast	contrast	NN
cord-015021-pol2qm74	4404	3	,	,	,
cord-015021-pol2qm74	4404	4	LPS	LPS	NNP
cord-015021-pol2qm74	4404	5	challenge	challenge	NN
cord-015021-pol2qm74	4404	6	induced	induce	VBN
cord-015021-pol2qm74	4404	7	dramatic	dramatic	JJ
cord-015021-pol2qm74	4404	8	elevation	elevation	NN
cord-015021-pol2qm74	4404	9	of	of	IN
cord-015021-pol2qm74	4404	10	IL	IL	NNP
cord-015021-pol2qm74	4404	11	-	-	HYPH
cord-015021-pol2qm74	4404	12	t~	t~	NNP
cord-015021-pol2qm74	4404	13	in	in	IN
cord-015021-pol2qm74	4404	14	all	all	DT
cord-015021-pol2qm74	4404	15	organs	organ	NNS
cord-015021-pol2qm74	4404	16	tested	test	VBN
cord-015021-pol2qm74	4404	17	except	except	IN
cord-015021-pol2qm74	4404	18	for	for	IN
cord-015021-pol2qm74	4404	19	the	the	DT
cord-015021-pol2qm74	4404	20	kidney	kidney	NN
cord-015021-pol2qm74	4404	21	;	;	:
cord-015021-pol2qm74	4404	22	the	the	DT
cord-015021-pol2qm74	4404	23	spleen	spleen	NN
cord-015021-pol2qm74	4404	24	was	be	VBD
cord-015021-pol2qm74	4404	25	the	the	DT
cord-015021-pol2qm74	4404	26	most	most	RBS
cord-015021-pol2qm74	4404	27	responsive	responsive	JJ
cord-015021-pol2qm74	4404	28	organ	organ	NN
cord-015021-pol2qm74	4404	29	to	to	IN
cord-015021-pol2qm74	4404	30	LPS	LPS	NNP
cord-015021-pol2qm74	4404	31	-	-	HYPH
cord-015021-pol2qm74	4404	32	induced	induce	VBN
cord-015021-pol2qm74	4404	33	IL	IL	NNP
cord-015021-pol2qm74	4404	34	-	-	HYPH
cord-015021-pol2qm74	4404	35	lo~	lo~	JJ
cord-015021-pol2qm74	4404	36	production	production	NN
cord-015021-pol2qm74	4404	37	.	.	.
cord-015021-pol2qm74	4405	1	These	these	DT
cord-015021-pol2qm74	4405	2	data	datum	NNS
cord-015021-pol2qm74	4405	3	indicate	indicate	VBP
cord-015021-pol2qm74	4405	4	that	that	IN
cord-015021-pol2qm74	4405	5	thermal	thermal	JJ
cord-015021-pol2qm74	4405	6	or	or	CC
cord-015021-pol2qm74	4405	7	mechanical	mechanical	JJ
cord-015021-pol2qm74	4405	8	injuries	injury	NNS
cord-015021-pol2qm74	4405	9	induce	induce	VBP
cord-015021-pol2qm74	4405	10	very	very	RB
cord-015021-pol2qm74	4405	11	early	early	JJ
cord-015021-pol2qm74	4405	12	and	and	CC
cord-015021-pol2qm74	4405	13	organ	organ	NN
cord-015021-pol2qm74	4405	14	specific	specific	JJ
cord-015021-pol2qm74	4405	15	production	production	NN
cord-015021-pol2qm74	4405	16	of	of	IN
cord-015021-pol2qm74	4405	17	IL-1	IL-1	NNP
cord-015021-pol2qm74	4405	18	c~	c~	NNP
cord-015021-pol2qm74	4405	19	in	in	IN
cord-015021-pol2qm74	4405	20	vivo	vivo	NN
cord-015021-pol2qm74	4405	21	by	by	IN
cord-015021-pol2qm74	4405	22	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4405	23	other	other	JJ
cord-015021-pol2qm74	4405	24	than	than	IN
cord-015021-pol2qm74	4405	25	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4405	26	.	.	.
cord-015021-pol2qm74	4406	1	Injury	injury	NN
cord-015021-pol2qm74	4406	2	-	-	HYPH
cord-015021-pol2qm74	4406	3	induced	induce	VBN
cord-015021-pol2qm74	4406	4	complement	complement	NN
cord-015021-pol2qm74	4406	5	and	and	CC
cord-015021-pol2qm74	4406	6	platelet	platelet	NN
cord-015021-pol2qm74	4406	7	activation	activation	NN
cord-015021-pol2qm74	4406	8	may	may	MD
cord-015021-pol2qm74	4406	9	be	be	VB
cord-015021-pol2qm74	4406	10	involved	involve	VBN
cord-015021-pol2qm74	4406	11	as	as	RB
cord-015021-pol2qm74	4406	12	well	well	RB
cord-015021-pol2qm74	4406	13	as	as	IN
cord-015021-pol2qm74	4406	14	the	the	DT
cord-015021-pol2qm74	4406	15	neuro	neuro	NNP
cord-015021-pol2qm74	4406	16	-	-	HYPH
cord-015021-pol2qm74	4406	17	endocrine	endocrine	JJ
cord-015021-pol2qm74	4406	18	axis	axis	NN
cord-015021-pol2qm74	4406	19	,	,	,
cord-015021-pol2qm74	4406	20	which	which	WDT
cord-015021-pol2qm74	4406	21	may	may	MD
cord-015021-pol2qm74	4406	22	explain	explain	VB
cord-015021-pol2qm74	4406	23	the	the	DT
cord-015021-pol2qm74	4406	24	low	low	JJ
cord-015021-pol2qm74	4406	25	levels	level	NNS
cord-015021-pol2qm74	4406	26	of	of	IN
cord-015021-pol2qm74	4406	27	IL	IL	NNP
cord-015021-pol2qm74	4406	28	-	-	HYPH
cord-015021-pol2qm74	4406	29	lo~	lo~	NNP
cord-015021-pol2qm74	4406	30	induction	induction	NN
cord-015021-pol2qm74	4406	31	observed	observe	VBD
cord-015021-pol2qm74	4406	32	in	in	IN
cord-015021-pol2qm74	4406	33	all	all	DT
cord-015021-pol2qm74	4406	34	rats	rat	NNS
cord-015021-pol2qm74	4406	35	at	at	IN
cord-015021-pol2qm74	4406	36	the	the	DT
cord-015021-pol2qm74	4406	37	very	very	RB
cord-015021-pol2qm74	4406	38	early	early	JJ
cord-015021-pol2qm74	4406	39	time	time	NN
cord-015021-pol2qm74	4406	40	-	-	HYPH
cord-015021-pol2qm74	4406	41	points	point	NNS
cord-015021-pol2qm74	4406	42	.	.	.
cord-015021-pol2qm74	4407	1	Trauma	Trauma	NNP
cord-015021-pol2qm74	4407	2	Services	Services	NNPS
cord-015021-pol2qm74	4407	3	,	,	,
cord-015021-pol2qm74	4407	4	Massachusetts	Massachusetts	NNP
cord-015021-pol2qm74	4407	5	General	General	NNP
cord-015021-pol2qm74	4407	6	Hospital	Hospital	NNP
cord-015021-pol2qm74	4407	7	,	,	,
cord-015021-pol2qm74	4407	8	and	and	CC
cord-015021-pol2qm74	4407	9	Department	Department	NNP
cord-015021-pol2qm74	4407	10	of	of	IN
cord-015021-pol2qm74	4407	11	Surgery	Surgery	NNP
cord-015021-pol2qm74	4407	12	,	,	,
cord-015021-pol2qm74	4407	13	Harvard	Harvard	NNP
cord-015021-pol2qm74	4407	14	Medical	Medical	NNP
cord-015021-pol2qm74	4407	15	School	School	NNP
cord-015021-pol2qm74	4407	16	.	.	.
cord-015021-pol2qm74	4408	1	Fruit	Fruit	NNP
cord-015021-pol2qm74	4408	2	,	,	,
cord-015021-pol2qm74	4408	3	St	St	NNP
cord-015021-pol2qm74	4408	4	,	,	,
cord-015021-pol2qm74	4408	5	Boston	Boston	NNP
cord-015021-pol2qm74	4408	6	,	,	,
cord-015021-pol2qm74	4408	7	MA	MA	NNP
cord-015021-pol2qm74	4408	8	02114	02114	CD
cord-015021-pol2qm74	4408	9	.	.	.
cord-015021-pol2qm74	4409	1	J.	J.	NNP
cord-015021-pol2qm74	4409	2	F.	F.	NNP
cord-015021-pol2qm74	4409	3	Schmand	Schmand	NNP
cord-015021-pol2qm74	4409	4	*	*	NFP
cord-015021-pol2qm74	4409	5	#	#	NN
cord-015021-pol2qm74	4409	6	,	,	,
cord-015021-pol2qm74	4409	7	A.	A.	NNP
cord-015021-pol2qm74	4409	8	Ayala	Ayala	NNP
cord-015021-pol2qm74	4409	9	*	*	NFP
cord-015021-pol2qm74	4409	10	and	and	CC
cord-015021-pol2qm74	4409	11	I.	I.	NNP
cord-015021-pol2qm74	4409	12	H.	H.	NNP
cord-015021-pol2qm74	4409	13	Chaudry	Chaudry	NNP
cord-015021-pol2qm74	4410	1	*	*	NFP
cord-015021-pol2qm74	4411	1	Studies	study	NNS
cord-015021-pol2qm74	4411	2	indicate	indicate	VBP
cord-015021-pol2qm74	4411	3	that	that	IN
cord-015021-pol2qm74	4411	4	i.v	i.v	NNP
cord-015021-pol2qm74	4411	5	.	.	.
cord-015021-pol2qm74	4411	6	infusion	infusion	NN
cord-015021-pol2qm74	4411	7	of	of	IN
cord-015021-pol2qm74	4411	8	the	the	DT
cord-015021-pol2qm74	4411	9	colloid	colloid	NN
cord-015021-pol2qm74	4411	10	HES	HES	NNP
cord-015021-pol2qm74	4411	11	in	in	IN
cord-015021-pol2qm74	4411	12	normal	normal	JJ
cord-015021-pol2qm74	4411	13	animals	animal	NNS
cord-015021-pol2qm74	4411	14	does	do	VBZ
cord-015021-pol2qm74	4411	15	not	not	RB
cord-015021-pol2qm74	4411	16	adversely	adversely	RB
cord-015021-pol2qm74	4411	17	affect	affect	VB
cord-015021-pol2qm74	4411	18	non	non	JJ
cord-015021-pol2qm74	4411	19	-	-	JJ
cord-015021-pol2qm74	4411	20	specific	specific	JJ
cord-015021-pol2qm74	4411	21	immunity	immunity	NN
cord-015021-pol2qm74	4411	22	.	.	.
cord-015021-pol2qm74	4412	1	It	-PRON-	PRP
cord-015021-pol2qm74	4412	2	remains	remain	VBZ
cord-015021-pol2qm74	4412	3	unknown	unknown	JJ
cord-015021-pol2qm74	4412	4	,	,	,
cord-015021-pol2qm74	4412	5	however	however	RB
cord-015021-pol2qm74	4412	6	,	,	,
cord-015021-pol2qm74	4413	1	if	if	IN
cord-015021-pol2qm74	4413	2	lIES	lies	JJ
cord-015021-pol2qm74	4413	3	affects	affect	VBZ
cord-015021-pol2qm74	4413	4	cell	cell	NN
cord-015021-pol2qm74	4413	5	mediated	mediate	VBN
cord-015021-pol2qm74	4413	6	,	,	,
cord-015021-pol2qm74	4413	7	specific	specific	JJ
cord-015021-pol2qm74	4413	8	immune	immune	JJ
cord-015021-pol2qm74	4413	9	functions	function	NNS
cord-015021-pol2qm74	4413	10	after	after	IN
cord-015021-pol2qm74	4413	11	trauma	trauma	NN
cord-015021-pol2qm74	4413	12	and	and	CC
cord-015021-pol2qm74	4413	13	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4413	14	(	(	-LRB-
cord-015021-pol2qm74	4413	15	hem	hem	NNP
cord-015021-pol2qm74	4413	16	)	)	-RRB-
cord-015021-pol2qm74	4413	17	.	.	.
cord-015021-pol2qm74	4414	1	To	to	TO
cord-015021-pol2qm74	4414	2	study	study	VB
cord-015021-pol2qm74	4414	3	this	this	DT
cord-015021-pol2qm74	4414	4	,	,	,
cord-015021-pol2qm74	4414	5	non	non	JJ
cord-015021-pol2qm74	4414	6	-	-	JJ
cord-015021-pol2qm74	4414	7	heparinized	heparinized	JJ
cord-015021-pol2qm74	4414	8	C3H	C3H	NNP
cord-015021-pol2qm74	4414	9	/	/	SYM
cord-015021-pol2qm74	4414	10	HeN	hen	JJ
cord-015021-pol2qm74	4414	11	mice	mouse	NNS
cord-015021-pol2qm74	4414	12	underwent	undergo	VBD
cord-015021-pol2qm74	4414	13	midline	midline	JJ
cord-015021-pol2qm74	4414	14	laparotomy	laparotomy	NN
cord-015021-pol2qm74	4414	15	to	to	TO
cord-015021-pol2qm74	4414	16	induce	induce	VB
cord-015021-pol2qm74	4414	17	trauma	trauma	NN
cord-015021-pol2qm74	4414	18	and	and	CC
cord-015021-pol2qm74	4414	19	were	be	VBD
cord-015021-pol2qm74	4414	20	then	then	RB
cord-015021-pol2qm74	4414	21	bled	bleed	VBN
cord-015021-pol2qm74	4414	22	to	to	IN
cord-015021-pol2qm74	4414	23	and	and	CC
cord-015021-pol2qm74	4414	24	maintained	maintain	VBD
cord-015021-pol2qm74	4414	25	at	at	IN
cord-015021-pol2qm74	4414	26	a	a	DT
cord-015021-pol2qm74	4414	27	BP	BP	NNP
cord-015021-pol2qm74	4414	28	of	of	IN
cord-015021-pol2qm74	4414	29	40	40	CD
cord-015021-pol2qm74	4414	30	mmI	mmI	NNP
cord-015021-pol2qm74	4414	31	-	-	HYPH
cord-015021-pol2qm74	4414	32	Ig	Ig	NNP
cord-015021-pol2qm74	4414	33	for	for	IN
cord-015021-pol2qm74	4414	34	60	60	CD
cord-015021-pol2qm74	4414	35	rain	rain	NN
cord-015021-pol2qm74	4414	36	.	.	.
cord-015021-pol2qm74	4415	1	The	the	DT
cord-015021-pol2qm74	4415	2	animals	animal	NNS
cord-015021-pol2qm74	4415	3	were	be	VBD
cord-015021-pol2qm74	4415	4	then	then	RB
cord-015021-pol2qm74	4415	5	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	4415	6	with	with	IN
cord-015021-pol2qm74	4415	7	either	either	DT
cord-015021-pol2qm74	4415	8	4	4	CD
cord-015021-pol2qm74	4415	9	times	time	NNS
cord-015021-pol2qm74	4415	10	(	(	-LRB-
cord-015021-pol2qm74	4416	1	x	x	LS
cord-015021-pol2qm74	4416	2	)	)	-RRB-
cord-015021-pol2qm74	4416	3	the	the	DT
cord-015021-pol2qm74	4416	4	shed	shed	JJ
cord-015021-pol2qm74	4416	5	blood	blood	NN
cord-015021-pol2qm74	4416	6	vohune	vohune	NN
cord-015021-pol2qm74	4416	7	as	as	IN
cord-015021-pol2qm74	4416	8	lactated	lactated	NNP
cord-015021-pol2qm74	4416	9	Ringer	Ringer	NNP
cord-015021-pol2qm74	4416	10	's	's	POS
cord-015021-pol2qm74	4416	11	solution	solution	NN
cord-015021-pol2qm74	4416	12	(	(	-LRB-
cord-015021-pol2qm74	4416	13	LRS	LRS	NNP
cord-015021-pol2qm74	4416	14	)	)	-RRB-
cord-015021-pol2qm74	4416	15	or	or	CC
cord-015021-pol2qm74	4416	16	2x	2x	CD
cord-015021-pol2qm74	4416	17	LRS	LRS	NNP
cord-015021-pol2qm74	4416	18	+	+	SYM
cord-015021-pol2qm74	4416	19	lx	lx	NNP
cord-015021-pol2qm74	4416	20	6	6	CD
cord-015021-pol2qm74	4416	21	%	%	NN
cord-015021-pol2qm74	4416	22	lIES	lie	NNS
cord-015021-pol2qm74	4416	23	.	.	.
cord-015021-pol2qm74	4417	1	Sham	sham	JJ
cord-015021-pol2qm74	4417	2	mice	mouse	NNS
cord-015021-pol2qm74	4417	3	were	be	VBD
cord-015021-pol2qm74	4417	4	neither	neither	CC
cord-015021-pol2qm74	4417	5	hemorrhaged	hemorrhage	VBN
cord-015021-pol2qm74	4417	6	nor	nor	CC
cord-015021-pol2qm74	4417	7	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	4417	8	.	.	.
cord-015021-pol2qm74	4418	1	At	at	IN
cord-015021-pol2qm74	4418	2	2	2	CD
cord-015021-pol2qm74	4418	3	or	or	CC
cord-015021-pol2qm74	4418	4	24	24	CD
cord-015021-pol2qm74	4418	5	hours	hour	NNS
cord-015021-pol2qm74	4418	6	post	post	NN
cord-015021-pol2qm74	4418	7	hem	hem	NNP
cord-015021-pol2qm74	4418	8	serum	serum	NN
cord-015021-pol2qm74	4418	9	,	,	,
cord-015021-pol2qm74	4418	10	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4418	11	(	(	-LRB-
cord-015021-pol2qm74	4418	12	PM~	PM~	NNP
cord-015021-pol2qm74	4418	13	)	)	-RRB-
cord-015021-pol2qm74	4418	14	and	and	CC
cord-015021-pol2qm74	4418	15	splenic	splenic	JJ
cord-015021-pol2qm74	4418	16	macrophages	macrophage	NNS
cord-015021-pol2qm74	4418	17	(	(	-LRB-
cord-015021-pol2qm74	4418	18	SM~	SM~	NNP
cord-015021-pol2qm74	4418	19	)	)	-RRB-
cord-015021-pol2qm74	4418	20	were	be	VBD
cord-015021-pol2qm74	4418	21	obtained	obtain	VBN
cord-015021-pol2qm74	4418	22	.	.	.
cord-015021-pol2qm74	4419	1	Bioassayes	Bioassayes	NNP
cord-015021-pol2qm74	4419	2	were	be	VBD
cord-015021-pol2qm74	4419	3	employed	employ	VBN
cord-015021-pol2qm74	4419	4	to	to	TO
cord-015021-pol2qm74	4419	5	assess	assess	VB
cord-015021-pol2qm74	4419	6	the	the	DT
cord-015021-pol2qm74	4419	7	levels	level	NNS
cord-015021-pol2qm74	4419	8	of	of	IN
cord-015021-pol2qm74	4419	9	II	II	NNP
cord-015021-pol2qm74	4419	10	-	-	HYPH
cord-015021-pol2qm74	4419	11	l	l	NNP
cord-015021-pol2qm74	4419	12	,	,	,
cord-015021-pol2qm74	4420	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	4420	2	(	(	-LRB-
cord-015021-pol2qm74	4420	3	Alternatively	alternatively	RB
cord-015021-pol2qm74	4420	4	PMqb	PMqb	NNP
cord-015021-pol2qm74	4420	5	showed	show	VBD
cord-015021-pol2qm74	4420	6	no	no	DT
cord-015021-pol2qm74	4420	7	differences	difference	NNS
cord-015021-pol2qm74	4420	8	in	in	IN
cord-015021-pol2qm74	4420	9	IL-1	IL-1	NNP
cord-015021-pol2qm74	4420	10	release	release	NN
cord-015021-pol2qm74	4420	11	between	between	IN
cord-015021-pol2qm74	4420	12	all	all	DT
cord-015021-pol2qm74	4420	13	groups	group	NNS
cord-015021-pol2qm74	4420	14	at	at	IN
cord-015021-pol2qm74	4420	15	2	2	CD
cord-015021-pol2qm74	4420	16	and	and	CC
cord-015021-pol2qm74	4420	17	24h	24h	NNS
cord-015021-pol2qm74	4420	18	,	,	,
cord-015021-pol2qm74	4420	19	while	while	IN
cord-015021-pol2qm74	4420	20	SM~	SM~	NNP
cord-015021-pol2qm74	4420	21	from	from	IN
cord-015021-pol2qm74	4420	22	the	the	DT
cord-015021-pol2qm74	4420	23	LRS	LRS	NNP
cord-015021-pol2qm74	4420	24	+	+	CC
cord-015021-pol2qm74	4420	25	HEN	HEN	NNP
cord-015021-pol2qm74	4420	26	group	group	NN
cord-015021-pol2qm74	4420	27	showed	show	VBD
cord-015021-pol2qm74	4420	28	a	a	DT
cord-015021-pol2qm74	4420	29	depression	depression	NN
cord-015021-pol2qm74	4420	30	at	at	IN
cord-015021-pol2qm74	4420	31	24h	24h	NNS
cord-015021-pol2qm74	4420	32	.	.	.
cord-015021-pol2qm74	4421	1	TNF	tnf	NN
cord-015021-pol2qm74	4421	2	production	production	NN
cord-015021-pol2qm74	4421	3	by	by	IN
cord-015021-pol2qm74	4421	4	PM~	PM~	NNP
cord-015021-pol2qm74	4421	5	was	be	VBD
cord-015021-pol2qm74	4421	6	depressed	depressed	JJ
cord-015021-pol2qm74	4421	7	in	in	IN
cord-015021-pol2qm74	4421	8	all	all	DT
cord-015021-pol2qm74	4421	9	groups	group	NNS
cord-015021-pol2qm74	4421	10	at	at	IN
cord-015021-pol2qm74	4421	11	2h	2h	CD
cord-015021-pol2qm74	4421	12	and	and	CC
cord-015021-pol2qm74	4421	13	remained	remain	VBD
cord-015021-pol2qm74	4421	14	so	so	RB
cord-015021-pol2qm74	4421	15	in	in	IN
cord-015021-pol2qm74	4421	16	the	the	DT
cord-015021-pol2qm74	4421	17	LRS	LRS	NNP
cord-015021-pol2qm74	4421	18	+	+	SYM
cord-015021-pol2qm74	4421	19	HES	HES	NNP
cord-015021-pol2qm74	4421	20	group	group	NN
cord-015021-pol2qm74	4421	21	at	at	IN
cord-015021-pol2qm74	4421	22	24h	24h	NNS
cord-015021-pol2qm74	4421	23	.	.	.
cord-015021-pol2qm74	4422	1	SM	SM	NNP
cord-015021-pol2qm74	4423	1	~b	~b	NNP
cord-015021-pol2qm74	4423	2	showed	show	VBD
cord-015021-pol2qm74	4423	3	decreased	decrease	VBD
cord-015021-pol2qm74	4423	4	TNF	TNF	NNP
cord-015021-pol2qm74	4423	5	release	release	NN
cord-015021-pol2qm74	4423	6	values	value	NNS
cord-015021-pol2qm74	4423	7	in	in	IN
cord-015021-pol2qm74	4423	8	both	both	CC
cord-015021-pol2qm74	4423	9	hem	hem	NNP
cord-015021-pol2qm74	4423	10	groups	group	NNS
cord-015021-pol2qm74	4423	11	at	at	IN
cord-015021-pol2qm74	4423	12	2	2	CD
cord-015021-pol2qm74	4423	13	and	and	CC
cord-015021-pol2qm74	4423	14	24h	24h	NNS
cord-015021-pol2qm74	4423	15	.	.	.
cord-015021-pol2qm74	4424	1	In	in	IN
cord-015021-pol2qm74	4424	2	summary	summary	NN
cord-015021-pol2qm74	4424	3	,	,	,
cord-015021-pol2qm74	4424	4	the	the	DT
cord-015021-pol2qm74	4424	5	levels	level	NNS
cord-015021-pol2qm74	4424	6	of	of	IN
cord-015021-pol2qm74	4424	7	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4424	8	cytokines	cytokine	NNS
cord-015021-pol2qm74	4424	9	(	(	-LRB-
cord-015021-pol2qm74	4424	10	particularly	particularly	RB
cord-015021-pol2qm74	4424	11	the	the	DT
cord-015021-pol2qm74	4424	12	values	value	NNS
cord-015021-pol2qm74	4424	13	of	of	IN
cord-015021-pol2qm74	4424	14	circulating	circulate	VBG
cord-015021-pol2qm74	4424	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	4424	16	)	)	-RRB-
cord-015021-pol2qm74	4424	17	after	after	IN
cord-015021-pol2qm74	4424	18	trauma	trauma	NN
cord-015021-pol2qm74	4424	19	/	/	SYM
cord-015021-pol2qm74	4424	20	hem	hem	NNS
cord-015021-pol2qm74	4424	21	are	be	VBP
cord-015021-pol2qm74	4424	22	positively	positively	RB
cord-015021-pol2qm74	4424	23	influenced	influence	VBN
cord-015021-pol2qm74	4424	24	by	by	IN
cord-015021-pol2qm74	4424	25	the	the	DT
cord-015021-pol2qm74	4424	26	administration	administration	NN
cord-015021-pol2qm74	4424	27	of	of	IN
cord-015021-pol2qm74	4424	28	HES	HES	NNP
cord-015021-pol2qm74	4424	29	.	.	.
cord-015021-pol2qm74	4425	1	This	this	DT
cord-015021-pol2qm74	4425	2	might	may	MD
cord-015021-pol2qm74	4425	3	be	be	VB
cord-015021-pol2qm74	4425	4	due	due	JJ
cord-015021-pol2qm74	4425	5	to	to	IN
cord-015021-pol2qm74	4425	6	a	a	DT
cord-015021-pol2qm74	4425	7	protective	protective	JJ
cord-015021-pol2qm74	4425	8	effect	effect	NN
cord-015021-pol2qm74	4425	9	on	on	IN
cord-015021-pol2qm74	4425	10	PMqb	PMqb	NNP
cord-015021-pol2qm74	4425	11	and	and	CC
cord-015021-pol2qm74	4425	12	SM~	SM~	NNP
cord-015021-pol2qm74	4425	13	,	,	,
cord-015021-pol2qm74	4425	14	but	but	CC
cord-015021-pol2qm74	4425	15	also	also	RB
cord-015021-pol2qm74	4425	16	on	on	IN
cord-015021-pol2qm74	4425	17	other	other	JJ
cord-015021-pol2qm74	4425	18	cytokine	cytokine	NN
cord-015021-pol2qm74	4425	19	producing	produce	VBG
cord-015021-pol2qm74	4425	20	cells	cell	NNS
cord-015021-pol2qm74	4425	21	,	,	,
cord-015021-pol2qm74	4425	22	e.g.	e.g.	RB
cord-015021-pol2qm74	4425	23	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	4425	24	ceils	ceil	NNS
cord-015021-pol2qm74	4425	25	.	.	.
cord-015021-pol2qm74	4426	1	We	-PRON-	PRP
cord-015021-pol2qm74	4426	2	conclude	conclude	VBP
cord-015021-pol2qm74	4426	3	that	that	IN
cord-015021-pol2qm74	4426	4	HES	HES	NNP
cord-015021-pol2qm74	4426	5	is	be	VBZ
cord-015021-pol2qm74	4426	6	not	not	RB
cord-015021-pol2qm74	4426	7	only	only	RB
cord-015021-pol2qm74	4426	8	a	a	DT
cord-015021-pol2qm74	4426	9	safe	safe	JJ
cord-015021-pol2qm74	4426	10	,	,	,
cord-015021-pol2qm74	4426	11	but	but	CC
cord-015021-pol2qm74	4426	12	also	also	RB
cord-015021-pol2qm74	4426	13	beneficial	beneficial	JJ
cord-015021-pol2qm74	4426	14	agent	agent	NN
cord-015021-pol2qm74	4426	15	in	in	IN
cord-015021-pol2qm74	4426	16	the	the	DT
cord-015021-pol2qm74	4426	17	resuscitation	resuscitation	NN
cord-015021-pol2qm74	4426	18	of	of	IN
cord-015021-pol2qm74	4426	19	patients	patient	NNS
cord-015021-pol2qm74	4427	1	atler	atler	NNP
cord-015021-pol2qm74	4427	2	trauma	trauma	NNP
cord-015021-pol2qm74	4427	3	/	/	SYM
cord-015021-pol2qm74	4427	4	bemorrhagic	bemorrhagic	NN
cord-015021-pol2qm74	4427	5	shock	shock	NN
cord-015021-pol2qm74	4427	6	.	.	.
cord-015021-pol2qm74	4428	1	This	this	DT
cord-015021-pol2qm74	4428	2	study	study	NN
cord-015021-pol2qm74	4428	3	investigated	investigate	VBD
cord-015021-pol2qm74	4428	4	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4428	5	and	and	CC
cord-015021-pol2qm74	4428	6	consecutlve	consecutlve	NN
cord-015021-pol2qm74	4428	7	immune	immune	JJ
cord-015021-pol2qm74	4428	8	response	response	NN
cord-015021-pol2qm74	4428	9	in	in	IN
cord-015021-pol2qm74	4428	10	39	39	CD
cord-015021-pol2qm74	4428	11	patients	patient	NNS
cord-015021-pol2qm74	4428	12	with	with	IN
cord-015021-pol2qm74	4428	13	multiple	multiple	JJ
cord-015021-pol2qm74	4428	14	trauma	trauma	NN
cord-015021-pol2qm74	4428	15	(	(	-LRB-
cord-015021-pol2qm74	4428	16	median	median	JJ
cord-015021-pol2qm74	4428	17	Injury	injury	NN
cord-015021-pol2qm74	4428	18	Severity	severity	NN
cord-015021-pol2qm74	4428	19	Score	score	NN
cord-015021-pol2qm74	4428	20	=	=	SYM
cord-015021-pol2qm74	4428	21	20,5	20,5	CD
cord-015021-pol2qm74	4428	22	)	)	-RRB-
cord-015021-pol2qm74	4428	23	.	.	.
cord-015021-pol2qm74	4429	1	Blood	blood	NN
cord-015021-pol2qm74	4429	2	samples.were	samples.were	RB
cord-015021-pol2qm74	4429	3	collected	collect	VBN
cord-015021-pol2qm74	4429	4	shortly	shortly	RB
cord-015021-pol2qm74	4429	5	after	after	IN
cord-015021-pol2qm74	4429	6	injury	injury	NN
cord-015021-pol2qm74	4429	7	and	and	CC
cord-015021-pol2qm74	4429	8	after	after	IN
cord-015021-pol2qm74	4429	9	0,5	0,5	CD
cord-015021-pol2qm74	4429	10	,	,	,
cord-015021-pol2qm74	4429	11	1	1	CD
cord-015021-pol2qm74	4429	12	,	,	,
cord-015021-pol2qm74	4429	13	3	3	CD
cord-015021-pol2qm74	4429	14	,	,	,
cord-015021-pol2qm74	4429	15	S	S	NNP
cord-015021-pol2qm74	4429	16	and	and	CC
cord-015021-pol2qm74	4429	17	l0	l0	NNP
cord-015021-pol2qm74	4429	18	days	day	NNS
cord-015021-pol2qm74	4429	19	.	.	.
cord-015021-pol2qm74	4430	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	4430	2	was	be	VBD
cord-015021-pol2qm74	4430	3	measured	measure	VBN
cord-015021-pol2qm74	4430	4	with	with	IN
cord-015021-pol2qm74	4430	5	limulus	limulus	NNP
cord-015021-pol2qm74	4430	6	-	-	HYPH
cord-015021-pol2qm74	4430	7	amebocyte	amebocyte	NN
cord-015021-pol2qm74	4430	8	lysate	lysate	NN
cord-015021-pol2qm74	4430	9	test	test	NN
cord-015021-pol2qm74	4430	10	and	and	CC
cord-015021-pol2qm74	4430	11	the	the	DT
cord-015021-pol2qm74	4430	12	specific	specific	JJ
cord-015021-pol2qm74	4430	13	antibody	antibody	NN
cord-015021-pol2qm74	4430	14	content	content	NN
cord-015021-pol2qm74	4430	15	(	(	-LRB-
cord-015021-pol2qm74	4430	16	SAC	SAC	NNP
cord-015021-pol2qm74	4430	17	)	)	-RRB-
cord-015021-pol2qm74	4430	18	against	against	IN
cord-015021-pol2qm74	4430	19	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	4430	20	of	of	IN
cord-015021-pol2qm74	4430	21	the	the	DT
cord-015021-pol2qm74	4430	22	classes	class	NNS
cord-015021-pol2qm74	4430	23	IgG	IgG	NNP
cord-015021-pol2qm74	4430	24	,	,	,
cord-015021-pol2qm74	4430	25	IgM	IgM	NNP
cord-015021-pol2qm74	4430	26	and	and	CC
cord-015021-pol2qm74	4430	27	lgA	lgA	NNP
cord-015021-pol2qm74	4430	28	by	by	IN
cord-015021-pol2qm74	4430	29	ELISA	ELISA	NNP
cord-015021-pol2qm74	4430	30	-	-	HYPH
cord-015021-pol2qm74	4430	31	technique	technique	NN
cord-015021-pol2qm74	4430	32	.	.	.
cord-015021-pol2qm74	4431	1	Five	five	CD
cord-015021-pol2qm74	4431	2	antigens	antigen	NNS
cord-015021-pol2qm74	4431	3	were	be	VBD
cord-015021-pol2qm74	4431	4	used	use	VBN
cord-015021-pol2qm74	4431	5	:	:	:
cord-015021-pol2qm74	4431	6	Lipopolysaccaride	Lipopolysaccaride	NNP
cord-015021-pol2qm74	4431	7	(	(	-LRB-
cord-015021-pol2qm74	4431	8	LPS	LPS	NNP
cord-015021-pol2qm74	4431	9	)	)	-RRB-
cord-015021-pol2qm74	4431	10	of	of	IN
cord-015021-pol2qm74	4431	11	E.coli	E.coli	NNS
cord-015021-pol2qm74	4431	12	(	(	-LRB-
cord-015021-pol2qm74	4431	13	EC	EC	NNP
cord-015021-pol2qm74	4431	14	)	)	-RRB-
cord-015021-pol2qm74	4431	15	,	,	,
cord-015021-pol2qm74	4431	16	Lipid	Lipid	NNP
cord-015021-pol2qm74	4431	17	A	a	NN
cord-015021-pol2qm74	4431	18	of	of	IN
cord-015021-pol2qm74	4431	19	E.coli	E.coli	NNS
cord-015021-pol2qm74	4431	20	(	(	-LRB-
cord-015021-pol2qm74	4431	21	LA	LA	NNP
cord-015021-pol2qm74	4431	22	)	)	-RRB-
cord-015021-pol2qm74	4431	23	,	,	,
cord-015021-pol2qm74	4431	24	LPS	LPS	NNP
cord-015021-pol2qm74	4431	25	of	of	IN
cord-015021-pol2qm74	4431	26	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	4431	27	aerog	aerog	VBZ
cord-015021-pol2qm74	4431	28	.	.	.
cord-015021-pol2qm74	4432	1	(	(	-LRB-
cord-015021-pol2qm74	4432	2	PA	PA	NNP
cord-015021-pol2qm74	4432	3	)	)	-RRB-
cord-015021-pol2qm74	4432	4	,	,	,
cord-015021-pol2qm74	4432	5	LPS	LPS	NNP
cord-015021-pol2qm74	4432	6	of	of	IN
cord-015021-pol2qm74	4432	7	Vibrin	Vibrin	NNP
cord-015021-pol2qm74	4432	8	cholerae	cholerae	NN
cord-015021-pol2qm74	4432	9	(	(	-LRB-
cord-015021-pol2qm74	4432	10	VC	VC	NNP
cord-015021-pol2qm74	4432	11	)	)	-RRB-
cord-015021-pol2qm74	4432	12	and	and	CC
cord-015021-pol2qm74	4432	13	cX	cX	NNP
cord-015021-pol2qm74	4432	14	-	-	HYPH
cord-015021-pol2qm74	4432	15	Hemolysin	Hemolysin	NNP
cord-015021-pol2qm74	4432	16	of	of	IN
cord-015021-pol2qm74	4432	17	Staphylococcus	Staphylococcus	NNP
cord-015021-pol2qm74	4432	18	anreus	anreu	NNS
cord-015021-pol2qm74	4432	19	(	(	-LRB-
cord-015021-pol2qm74	4432	20	OtH	OtH	NNP
cord-015021-pol2qm74	4432	21	)	)	-RRB-
cord-015021-pol2qm74	4432	22	.	.	.
cord-015021-pol2qm74	4433	1	A	a	DT
cord-015021-pol2qm74	4433	2	nephelometer	nephelometer	NN
cord-015021-pol2qm74	4433	3	indicated	indicate	VBD
cord-015021-pol2qm74	4433	4	the	the	DT
cord-015021-pol2qm74	4433	5	total	total	JJ
cord-015021-pol2qm74	4433	6	concentrations	concentration	NNS
cord-015021-pol2qm74	4433	7	of	of	IN
cord-015021-pol2qm74	4433	8	IgG	IgG	NNP
cord-015021-pol2qm74	4433	9	,	,	,
cord-015021-pol2qm74	4433	10	IgM	IgM	NNP
cord-015021-pol2qm74	4433	11	and	and	CC
cord-015021-pol2qm74	4434	1	IgA.	IgA.	NNP
cord-015021-pol2qm74	4435	1	Differences	difference	NNS
cord-015021-pol2qm74	4435	2	were	be	VBD
cord-015021-pol2qm74	4435	3	checked	check	VBN
cord-015021-pol2qm74	4435	4	with	with	IN
cord-015021-pol2qm74	4435	5	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	4435	6	-	-	HYPH
cord-015021-pol2qm74	4435	7	test	test	NN
cord-015021-pol2qm74	4435	8	and	and	CC
cord-015021-pol2qm74	4435	9	p<0,0S	p<0,0S	NNP
cord-015021-pol2qm74	4435	10	was	be	VBD
cord-015021-pol2qm74	4435	11	considered	consider	VBN
cord-015021-pol2qm74	4435	12	significant	significant	JJ
cord-015021-pol2qm74	4435	13	.	.	.
cord-015021-pol2qm74	4436	1	Cross	cross	NN
cord-015021-pol2qm74	4436	2	-	-	NN
cord-015021-pol2qm74	4436	3	reactivity	reactivity	NN
cord-015021-pol2qm74	4436	4	was	be	VBD
cord-015021-pol2qm74	4436	5	calculated	calculate	VBN
cord-015021-pol2qm74	4436	6	with	with	IN
cord-015021-pol2qm74	4436	7	rank	rank	NN
cord-015021-pol2qm74	4436	8	correlation	correlation	NN
cord-015021-pol2qm74	4436	9	coefficients	coefficient	NNS
cord-015021-pol2qm74	4436	10	.	.	.
cord-015021-pol2qm74	4437	1	Results	result	NNS
cord-015021-pol2qm74	4437	2	:	:	:
cord-015021-pol2qm74	4438	1	Endotoxemia	Endotoxemia	NNP
cord-015021-pol2qm74	4438	2	peaked	peak	VBD
cord-015021-pol2qm74	4438	3	shortly	shortly	RB
cord-015021-pol2qm74	4438	4	after	after	IN
cord-015021-pol2qm74	4438	5	injury	injury	NN
cord-015021-pol2qm74	4438	6	(	(	-LRB-
cord-015021-pol2qm74	4438	7	0	0	CD
cord-015021-pol2qm74	4438	8	-	-	HYPH
cord-015021-pol2qm74	4438	9	3h	3h	CD
cord-015021-pol2qm74	4438	10	)	)	-RRB-
cord-015021-pol2qm74	4438	11	at	at	IN
cord-015021-pol2qm74	4438	12	0,425	0,425	CD
cord-015021-pol2qm74	4438	13	EkI	EkI	NNP
cord-015021-pol2qm74	4438	14	/	/	,
cord-015021-pol2qm74	4438	15	ml	ml	NN
cord-015021-pol2qm74	4438	16	(	(	-LRB-
cord-015021-pol2qm74	4438	17	median	median	NN
cord-015021-pol2qm74	4438	18	)	)	-RRB-
cord-015021-pol2qm74	4438	19	,	,	,
cord-015021-pol2qm74	4438	20	decreased	decrease	VBD
cord-015021-pol2qm74	4438	21	thereafter	thereafter	RB
cord-015021-pol2qm74	4438	22	to	to	IN
cord-015021-pol2qm74	4438	23	0,04	0,04	CD
cord-015021-pol2qm74	4438	24	EH	EH	NNP
cord-015021-pol2qm74	4438	25	/	/	,
cord-015021-pol2qm74	4438	26	ml	ml	NN
cord-015021-pol2qm74	4438	27	at	at	IN
cord-015021-pol2qm74	4438	28	day	day	NN
cord-015021-pol2qm74	4438	29	S	S	NNP
cord-015021-pol2qm74	4438	30	and	and	CC
cord-015021-pol2qm74	4438	31	remained	remain	VBD
cord-015021-pol2qm74	4438	32	on	on	IN
cord-015021-pol2qm74	4438	33	this	this	DT
cord-015021-pol2qm74	4438	34	level	level	NN
cord-015021-pol2qm74	4438	35	.	.	.
cord-015021-pol2qm74	4439	1	SAC	SAC	NNP
cord-015021-pol2qm74	4439	2	oflgMclass	oflgMclass	NNP
cord-015021-pol2qm74	4439	3	increased	increase	VBD
cord-015021-pol2qm74	4439	4	to	to	IN
cord-015021-pol2qm74	4439	5	all	all	DT
cord-015021-pol2qm74	4439	6	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	4439	7	and	and	CC
cord-015021-pol2qm74	4439	8	peaked	peak	VBD
cord-015021-pol2qm74	4439	9	at	at	IN
cord-015021-pol2qm74	4439	10	day	day	NN
cord-015021-pol2qm74	4439	11	3	3	CD
cord-015021-pol2qm74	4439	12	revealing	reveal	VBG
cord-015021-pol2qm74	4439	13	the	the	DT
cord-015021-pol2qm74	4439	14	lfighest	lfigh	JJS
cord-015021-pol2qm74	4439	15	level	level	NN
cord-015021-pol2qm74	4439	16	to	to	IN
cord-015021-pol2qm74	4439	17	LA	LA	NNP
cord-015021-pol2qm74	4439	18	followed	follow	VBN
cord-015021-pol2qm74	4439	19	by	by	IN
cord-015021-pol2qm74	4439	20	PA	PA	NNP
cord-015021-pol2qm74	4439	21	(=	(=	NNP
cord-015021-pol2qm74	4439	22	80	80	CD
cord-015021-pol2qm74	4439	23	%	%	NN
cord-015021-pol2qm74	4439	24	of	of	IN
cord-015021-pol2qm74	4439	25	LA	LA	NNP
cord-015021-pol2qm74	4439	26	-	-	HYPH
cord-015021-pol2qm74	4439	27	SAC	SAC	NNP
cord-015021-pol2qm74	4439	28	)	)	-RRB-
cord-015021-pol2qm74	4439	29	,	,	,
cord-015021-pol2qm74	4439	30	EC	EC	NNP
cord-015021-pol2qm74	4439	31	(=	(=	NNP
cord-015021-pol2qm74	4439	32	65	65	CD
cord-015021-pol2qm74	4439	33	%	%	NN
cord-015021-pol2qm74	4439	34	of	of	IN
cord-015021-pol2qm74	4439	35	LA	LA	NNP
cord-015021-pol2qm74	4439	36	-	-	HYPH
cord-015021-pol2qm74	4439	37	SAC	SAC	NNP
cord-015021-pol2qm74	4439	38	)	)	-RRB-
cord-015021-pol2qm74	4439	39	and	and	CC
cord-015021-pol2qm74	4439	40	VC	VC	NNP
cord-015021-pol2qm74	4439	41	(=	(=	NNP
cord-015021-pol2qm74	4439	42	40	40	CD
cord-015021-pol2qm74	4439	43	%	%	NN
cord-015021-pol2qm74	4439	44	of	of	IN
cord-015021-pol2qm74	4439	45	LA	LA	NNP
cord-015021-pol2qm74	4439	46	-	-	HYPH
cord-015021-pol2qm74	4439	47	SAC	SAC	NNP
cord-015021-pol2qm74	4439	48	)	)	-RRB-
cord-015021-pol2qm74	4439	49	.	.	.
cord-015021-pol2qm74	4440	1	lgA	lgA	NNP
cord-015021-pol2qm74	4440	2	antibodies	antibody	NNS
cord-015021-pol2qm74	4440	3	increased	increase	VBD
cord-015021-pol2qm74	4440	4	as	as	RB
cord-015021-pol2qm74	4440	5	well	well	RB
cord-015021-pol2qm74	4440	6	but	but	CC
cord-015021-pol2qm74	4440	7	only	only	RB
cord-015021-pol2qm74	4440	8	slightly	slightly	RB
cord-015021-pol2qm74	4440	9	and	and	CC
cord-015021-pol2qm74	4440	10	not	not	RB
cord-015021-pol2qm74	4440	11	significant	significant	JJ
cord-015021-pol2qm74	4440	12	(	(	-LRB-
cord-015021-pol2qm74	4440	13	exception	exception	NN
cord-015021-pol2qm74	4440	14	:	:	:
cord-015021-pol2qm74	4440	15	SAC	sac	NN
cord-015021-pol2qm74	4440	16	to	to	IN
cord-015021-pol2qm74	4440	17	LA	LA	NNP
cord-015021-pol2qm74	4440	18	was	be	VBD
cord-015021-pol2qm74	4440	19	elevated	elevate	VBN
cord-015021-pol2qm74	4440	20	significantly	significantly	RB
cord-015021-pol2qm74	4440	21	at	at	IN
cord-015021-pol2qm74	4440	22	day	day	NN
cord-015021-pol2qm74	4440	23	5	5	CD
cord-015021-pol2qm74	4440	24	)	)	-RRB-
cord-015021-pol2qm74	4440	25	.	.	.
cord-015021-pol2qm74	4441	1	IgG	IgG	NNP
cord-015021-pol2qm74	4441	2	antibodies	antibody	NNS
cord-015021-pol2qm74	4441	3	increased	increase	VBD
cord-015021-pol2qm74	4441	4	similar	similar	JJ
cord-015021-pol2qm74	4441	5	to	to	IN
cord-015021-pol2qm74	4441	6	IgA	IgA	NNP
cord-015021-pol2qm74	4441	7	class	class	NNP
cord-015021-pol2qm74	4441	8	only	only	RB
cord-015021-pol2qm74	4441	9	slightly	slightly	RB
cord-015021-pol2qm74	4441	10	and	and	CC
cord-015021-pol2qm74	4441	11	again	again	RB
cord-015021-pol2qm74	4441	12	only	only	RB
cord-015021-pol2qm74	4441	13	SAC	sac	NN
cord-015021-pol2qm74	4441	14	to	to	IN
cord-015021-pol2qm74	4441	15	LA	LA	NNP
cord-015021-pol2qm74	4441	16	was	be	VBD
cord-015021-pol2qm74	4441	17	significantly	significantly	RB
cord-015021-pol2qm74	4441	18	higher	high	JJR
cord-015021-pol2qm74	4441	19	at	at	IN
cord-015021-pol2qm74	4441	20	day	day	NN
cord-015021-pol2qm74	4441	21	5	5	CD
cord-015021-pol2qm74	4441	22	and	and	CC
cord-015021-pol2qm74	4441	23	10	10	CD
cord-015021-pol2qm74	4441	24	.	.	.
cord-015021-pol2qm74	4442	1	However	however	RB
cord-015021-pol2qm74	4442	2	SAC	sac	NN
cord-015021-pol2qm74	4442	3	to	to	IN
cord-015021-pol2qm74	4442	4	(	(	-LRB-
cord-015021-pol2qm74	4442	5	XH	xh	NN
cord-015021-pol2qm74	4442	6	of	of	IN
cord-015021-pol2qm74	4442	7	all	all	DT
cord-015021-pol2qm74	4442	8	Ig	Ig	NNP
cord-015021-pol2qm74	4442	9	-	-	HYPH
cord-015021-pol2qm74	4442	10	classes	class	NNS
cord-015021-pol2qm74	4442	11	remained	remain	VBD
cord-015021-pol2qm74	4442	12	continuously	continuously	RB
cord-015021-pol2qm74	4442	13	on	on	IN
cord-015021-pol2qm74	4442	14	the	the	DT
cord-015021-pol2qm74	4442	15	same	same	JJ
cord-015021-pol2qm74	4442	16	level	level	NN
cord-015021-pol2qm74	4442	17	troughout	troughout	VB
cord-015021-pol2qm74	4442	18	the	the	DT
cord-015021-pol2qm74	4442	19	observation	observation	NN
cord-015021-pol2qm74	4442	20	time	time	NN
cord-015021-pol2qm74	4442	21	.	.	.
cord-015021-pol2qm74	4443	1	Correlation	correlation	NN
cord-015021-pol2qm74	4443	2	analysis	analysis	NN
cord-015021-pol2qm74	4443	3	revealed	reveal	VBD
cord-015021-pol2qm74	4443	4	strong	strong	JJ
cord-015021-pol2qm74	4443	5	cross	cross	NN
cord-015021-pol2qm74	4443	6	-	-	NN
cord-015021-pol2qm74	4443	7	reactivity	reactivity	JJ
cord-015021-pol2qm74	4443	8	(	(	-LRB-
cord-015021-pol2qm74	4443	9	r>0,5	r>0,5	UH
cord-015021-pol2qm74	4443	10	;	;	:
cord-015021-pol2qm74	4443	11	p<0,01	p<0,01	NN
cord-015021-pol2qm74	4443	12	)	)	-RRB-
cord-015021-pol2qm74	4443	13	most	most	RBS
cord-015021-pol2qm74	4443	14	often	often	RB
cord-015021-pol2qm74	4443	15	between	between	IN
cord-015021-pol2qm74	4443	16	antibodies	antibody	NNS
cord-015021-pol2qm74	4443	17	of	of	IN
cord-015021-pol2qm74	4443	18	IgM	IgM	NNP
cord-015021-pol2qm74	4443	19	-	-	HYPH
cord-015021-pol2qm74	4443	20	elass	elass	NNP
cord-015021-pol2qm74	4443	21	(	(	-LRB-
cord-015021-pol2qm74	4443	22	73	73	CD
cord-015021-pol2qm74	4443	23	%	%	NN
cord-015021-pol2qm74	4443	24	)	)	-RRB-
cord-015021-pol2qm74	4443	25	followed	follow	VBN
cord-015021-pol2qm74	4443	26	by	by	IN
cord-015021-pol2qm74	4443	27	IgAclass	IgAclass	NNP
cord-015021-pol2qm74	4443	28	(	(	-LRB-
cord-015021-pol2qm74	4443	29	40	40	CD
cord-015021-pol2qm74	4443	30	%	%	NN
cord-015021-pol2qm74	4443	31	)	)	-RRB-
cord-015021-pol2qm74	4443	32	and	and	CC
cord-015021-pol2qm74	4443	33	lgG	lgG	NNP
cord-015021-pol2qm74	4443	34	class	class	NN
cord-015021-pol2qm74	4443	35	(	(	-LRB-
cord-015021-pol2qm74	4443	36	2	2	CD
cord-015021-pol2qm74	4443	37	%	%	NN
cord-015021-pol2qm74	4443	38	]	]	-RRB-
cord-015021-pol2qm74	4443	39	.	.	.
cord-015021-pol2qm74	4444	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	4444	2	:	:	:
cord-015021-pol2qm74	4445	1	Multiple	multiple	JJ
cord-015021-pol2qm74	4445	2	trauma	trauma	NN
cord-015021-pol2qm74	4445	3	is	be	VBZ
cord-015021-pol2qm74	4445	4	associated	associate	VBN
cord-015021-pol2qm74	4445	5	with	with	IN
cord-015021-pol2qm74	4445	6	temporary	temporary	JJ
cord-015021-pol2qm74	4445	7	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4445	8	.	.	.
cord-015021-pol2qm74	4446	1	Endotoxins	endotoxin	NNS
cord-015021-pol2qm74	4446	2	probably	probably	RB
cord-015021-pol2qm74	4446	3	translocated	translocate	VBD
cord-015021-pol2qm74	4446	4	from	from	IN
cord-015021-pol2qm74	4446	5	the	the	DT
cord-015021-pol2qm74	4446	6	gut	gut	NN
cord-015021-pol2qm74	4446	7	cause	cause	VB
cord-015021-pol2qm74	4446	8	specific	specific	JJ
cord-015021-pol2qm74	4446	9	increase	increase	NN
cord-015021-pol2qm74	4446	10	of	of	IN
cord-015021-pol2qm74	4446	11	anti	anti	JJ
cord-015021-pol2qm74	4446	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4446	13	antibodies	antibody	NNS
cord-015021-pol2qm74	4446	14	in	in	IN
cord-015021-pol2qm74	4446	15	blood	blood	NN
cord-015021-pol2qm74	4446	16	of	of	IN
cord-015021-pol2qm74	4446	17	the	the	DT
cord-015021-pol2qm74	4446	18	IgM	igm	NN
cord-015021-pol2qm74	4446	19	-	-	HYPH
cord-015021-pol2qm74	4446	20	class	class	NNP
cord-015021-pol2qm74	4446	21	.	.	.
cord-015021-pol2qm74	4447	1	Endotoxins	endotoxin	NNS
cord-015021-pol2qm74	4447	2	cause	cause	VBP
cord-015021-pol2qm74	4447	3	no	no	DT
cord-015021-pol2qm74	4447	4	increase	increase	NN
cord-015021-pol2qm74	4447	5	of	of	IN
cord-015021-pol2qm74	4447	6	antibodies	antibody	NNS
cord-015021-pol2qm74	4447	7	to	to	IN
cord-015021-pol2qm74	4447	8	gramposilave	gramposilave	NN
cord-015021-pol2qm74	4447	9	bacteria	bacteria	NNS
cord-015021-pol2qm74	4447	10	.	.	.
cord-015021-pol2qm74	4448	1	IgM	IgM	NNP
cord-015021-pol2qm74	4448	2	antibodies	antibody	NNS
cord-015021-pol2qm74	4448	3	are	be	VBP
cord-015021-pol2qm74	4448	4	most	most	RBS
cord-015021-pol2qm74	4448	5	unspecific	unspecific	JJ
cord-015021-pol2qm74	4448	6	.	.	.
cord-015021-pol2qm74	4449	1	During	during	IN
cord-015021-pol2qm74	4449	2	cardio	cardio	JJ
cord-015021-pol2qm74	4449	3	-	-	HYPH
cord-015021-pol2qm74	4449	4	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4449	5	bypass	bypass	NN
cord-015021-pol2qm74	4449	6	,	,	,
cord-015021-pol2qm74	4449	7	as	as	RB
cord-015021-pol2qm74	4449	8	well	well	RB
cord-015021-pol2qm74	4449	9	as	as	IN
cord-015021-pol2qm74	4449	10	postoperatively	postoperatively	RB
cord-015021-pol2qm74	4449	11	,	,	,
cord-015021-pol2qm74	4449	12	high	high	JJ
cord-015021-pol2qm74	4449	13	levels	level	NNS
cord-015021-pol2qm74	4449	14	of	of	IN
cord-015021-pol2qm74	4449	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4449	16	,	,	,
cord-015021-pol2qm74	4449	17	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	4449	18	(	(	-LRB-
cord-015021-pol2qm74	4449	19	II-6	II-6	NNP
cord-015021-pol2qm74	4449	20	)	)	-RRB-
cord-015021-pol2qm74	4449	21	and	and	CC
cord-015021-pol2qm74	4449	22	C	C	NNP
cord-015021-pol2qm74	4449	23	-	-	HYPH
cord-015021-pol2qm74	4449	24	reactive	reactive	JJ
cord-015021-pol2qm74	4449	25	protein	protein	NN
cord-015021-pol2qm74	4449	26	(	(	-LRB-
cord-015021-pol2qm74	4449	27	CRP	CRP	NNP
cord-015021-pol2qm74	4449	28	)	)	-RRB-
cord-015021-pol2qm74	4449	29	were	be	VBD
cord-015021-pol2qm74	4449	30	measured	measure	VBN
cord-015021-pol2qm74	4449	31	in	in	IN
cord-015021-pol2qm74	4449	32	30	30	CD
cord-015021-pol2qm74	4449	33	patients	patient	NNS
cord-015021-pol2qm74	4449	34	.	.	.
cord-015021-pol2qm74	4450	1	I0	i0	NN
cord-015021-pol2qm74	4450	2	female	female	JJ
cord-015021-pol2qm74	4450	3	and	and	CC
cord-015021-pol2qm74	4450	4	20	20	CD
cord-015021-pol2qm74	4450	5	male	male	JJ
cord-015021-pol2qm74	4450	6	,	,	,
cord-015021-pol2qm74	4450	7	ageing	age	VBG
cord-015021-pol2qm74	4450	8	from	from	IN
cord-015021-pol2qm74	4450	9	30	30	CD
cord-015021-pol2qm74	4450	10	to	to	IN
cord-015021-pol2qm74	4450	11	73	73	CD
cord-015021-pol2qm74	4450	12	with	with	IN
cord-015021-pol2qm74	4450	13	a	a	DT
cord-015021-pol2qm74	4450	14	median	median	JJ
cord-015021-pol2qm74	4450	15	age	age	NN
cord-015021-pol2qm74	4450	16	of	of	IN
cord-015021-pol2qm74	4450	17	59	59	CD
cord-015021-pol2qm74	4450	18	.	.	.
cord-015021-pol2qm74	4451	1	Blood	blood	NN
cord-015021-pol2qm74	4451	2	sampling	sampling	NN
cord-015021-pol2qm74	4451	3	was	be	VBD
cord-015021-pol2qm74	4451	4	done	do	VBN
cord-015021-pol2qm74	4451	5	preoperatively	preoperatively	RB
cord-015021-pol2qm74	4451	6	,	,	,
cord-015021-pol2qm74	4451	7	immediately	immediately	RB
cord-015021-pol2qm74	4451	8	after	after	IN
cord-015021-pol2qm74	4451	9	induction	induction	NN
cord-015021-pol2qm74	4451	10	of	of	IN
cord-015021-pol2qm74	4451	11	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4451	12	,	,	,
cord-015021-pol2qm74	4451	13	after	after	IN
cord-015021-pol2qm74	4451	14	thoracotomy	thoracotomy	NN
cord-015021-pol2qm74	4451	15	,	,	,
cord-015021-pol2qm74	4451	16	after	after	IN
cord-015021-pol2qm74	4451	17	cannulation	cannulation	NN
cord-015021-pol2qm74	4451	18	of	of	IN
cord-015021-pol2qm74	4451	19	the	the	DT
cord-015021-pol2qm74	4451	20	aorta	aorta	NNP
cord-015021-pol2qm74	4451	21	and	and	CC
cord-015021-pol2qm74	4451	22	right	right	JJ
cord-015021-pol2qm74	4451	23	atrium	atrium	NN
cord-015021-pol2qm74	4451	24	after	after	IN
cord-015021-pol2qm74	4451	25	the	the	DT
cord-015021-pol2qm74	4451	26	first	first	JJ
cord-015021-pol2qm74	4451	27	half	half	NN
cord-015021-pol2qm74	4451	28	of	of	IN
cord-015021-pol2qm74	4451	29	the	the	DT
cord-015021-pol2qm74	4451	30	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4451	31	phase	phase	NN
cord-015021-pol2qm74	4451	32	,	,	,
cord-015021-pol2qm74	4451	33	after	after	IN
cord-015021-pol2qm74	4451	34	closure	closure	NN
cord-015021-pol2qm74	4451	35	of	of	IN
cord-015021-pol2qm74	4451	36	the	the	DT
cord-015021-pol2qm74	4451	37	thorax	thorax	NN
cord-015021-pol2qm74	4451	38	,	,	,
cord-015021-pol2qm74	4451	39	2	2	CD
cord-015021-pol2qm74	4451	40	and	and	CC
cord-015021-pol2qm74	4451	41	4	4	CD
cord-015021-pol2qm74	4451	42	hours	hour	NNS
cord-015021-pol2qm74	4451	43	after	after	IN
cord-015021-pol2qm74	4451	44	the	the	DT
cord-015021-pol2qm74	4451	45	operation	operation	NN
cord-015021-pol2qm74	4452	1	and	and	CC
cord-015021-pol2qm74	4452	2	then	then	RB
cord-015021-pol2qm74	4452	3	every	every	DT
cord-015021-pol2qm74	4452	4	morning	morning	NN
cord-015021-pol2qm74	4452	5	until	until	IN
cord-015021-pol2qm74	4452	6	the	the	DT
cord-015021-pol2qm74	4452	7	5th	5th	JJ
cord-015021-pol2qm74	4452	8	postoperative	postoperative	JJ
cord-015021-pol2qm74	4452	9	day	day	NN
cord-015021-pol2qm74	4452	10	.	.	.
cord-015021-pol2qm74	4453	1	Blood	blood	NN
cord-015021-pol2qm74	4453	2	was	be	VBD
cord-015021-pol2qm74	4453	3	drawn	draw	VBN
cord-015021-pol2qm74	4453	4	into	into	IN
cord-015021-pol2qm74	4453	5	heparinized	heparinize	VBN
cord-015021-pol2qm74	4453	6	tubes	tube	NNS
cord-015021-pol2qm74	4453	7	(	(	-LRB-
cord-015021-pol2qm74	4453	8	I0	I0	NNP
cord-015021-pol2qm74	4453	9	IU	IU	NNP
cord-015021-pol2qm74	4453	10	/	/	SYM
cord-015021-pol2qm74	4453	11	ml	ml	NN
cord-015021-pol2qm74	4453	12	)	)	-RRB-
cord-015021-pol2qm74	4453	13	which	which	WDT
cord-015021-pol2qm74	4453	14	were	be	VBD
cord-015021-pol2qm74	4453	15	free	free	JJ
cord-015021-pol2qm74	4453	16	of	of	IN
cord-015021-pol2qm74	4453	17	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4453	18	.	.	.
cord-015021-pol2qm74	4454	1	CRP	CRP	NNP
cord-015021-pol2qm74	4454	2	levels	level	NNS
cord-015021-pol2qm74	4454	3	were	be	VBD
cord-015021-pol2qm74	4454	4	determined	determine	VBN
cord-015021-pol2qm74	4454	5	through	through	IN
cord-015021-pol2qm74	4454	6	the	the	DT
cord-015021-pol2qm74	4454	7	use	use	NN
cord-015021-pol2qm74	4454	8	of	of	IN
cord-015021-pol2qm74	4454	9	the	the	DT
cord-015021-pol2qm74	4454	10	Behring	Behring	NNP
cord-015021-pol2qm74	4454	11	Nephelometer	Nephelometer	NNP
cord-015021-pol2qm74	4454	12	.	.	.
cord-015021-pol2qm74	4455	1	11	11	CD
cord-015021-pol2qm74	4455	2	-	-	SYM
cord-015021-pol2qm74	4455	3	6	6	CD
cord-015021-pol2qm74	4455	4	levels	level	NNS
cord-015021-pol2qm74	4455	5	were	be	VBD
cord-015021-pol2qm74	4455	6	measured	measure	VBN
cord-015021-pol2qm74	4455	7	by	by	IN
cord-015021-pol2qm74	4455	8	using	use	VBG
cord-015021-pol2qm74	4455	9	commercially	commercially	RB
cord-015021-pol2qm74	4455	10	-	-	HYPH
cord-015021-pol2qm74	4455	11	available	available	JJ
cord-015021-pol2qm74	4455	12	ELISA	ELISA	NNP
cord-015021-pol2qm74	4455	13	test	test	NN
cord-015021-pol2qm74	4455	14	.	.	.
cord-015021-pol2qm74	4456	1	The	the	DT
cord-015021-pol2qm74	4456	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4456	3	level	level	NN
cord-015021-pol2qm74	4456	4	was	be	VBD
cord-015021-pol2qm74	4456	5	determined	determine	VBN
cord-015021-pol2qm74	4456	6	by	by	IN
cord-015021-pol2qm74	4456	7	a	a	DT
cord-015021-pol2qm74	4456	8	chromogenic	chromogenic	JJ
cord-015021-pol2qm74	4456	9	modification	modification	NN
cord-015021-pol2qm74	4456	10	of	of	IN
cord-015021-pol2qm74	4456	11	the	the	DT
cord-015021-pol2qm74	4456	12	limulus	limulus	NNP
cord-015021-pol2qm74	4456	13	amebocyte	amebocyte	NNP
cord-015021-pol2qm74	4456	14	test	test	NN
cord-015021-pol2qm74	4456	15	.	.	.
cord-015021-pol2qm74	4457	1	The	the	DT
cord-015021-pol2qm74	4457	2	statistical	statistical	JJ
cord-015021-pol2qm74	4457	3	analysis	analysis	NN
cord-015021-pol2qm74	4457	4	was	be	VBD
cord-015021-pol2qm74	4457	5	done	do	VBN
cord-015021-pol2qm74	4457	6	using	use	VBG
cord-015021-pol2qm74	4457	7	the	the	DT
cord-015021-pol2qm74	4457	8	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	4457	9	ranks	rank	VBZ
cord-015021-pol2qm74	4457	10	test	test	NN
cord-015021-pol2qm74	4457	11	and	and	CC
cord-015021-pol2qm74	4457	12	correlation	correlation	NN
cord-015021-pol2qm74	4457	13	analysis	analysis	NN
cord-015021-pol2qm74	4457	14	.	.	.
cord-015021-pol2qm74	4458	1	A	a	DT
cord-015021-pol2qm74	4458	2	significant	significant	JJ
cord-015021-pol2qm74	4458	3	increase	increase	NN
cord-015021-pol2qm74	4458	4	{	{	-LRB-
cord-015021-pol2qm74	4458	5	p	p	NN
cord-015021-pol2qm74	4458	6	0.01	0.01	CD
cord-015021-pol2qm74	4458	7	)	)	-RRB-
cord-015021-pol2qm74	4458	8	in	in	IN
cord-015021-pol2qm74	4458	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4458	10	plasma	plasma	NN
cord-015021-pol2qm74	4458	11	occurred	occur	VBD
cord-015021-pol2qm74	4458	12	during	during	IN
cord-015021-pol2qm74	4458	13	surgery	surgery	NN
cord-015021-pol2qm74	4458	14	,	,	,
cord-015021-pol2qm74	4458	15	culminating	culminate	VBG
cord-015021-pol2qm74	4458	16	in	in	IN
cord-015021-pol2qm74	4458	17	a	a	DT
cord-015021-pol2qm74	4458	18	peak	peak	NN
cord-015021-pol2qm74	4458	19	(	(	-LRB-
cord-015021-pol2qm74	4458	20	median	median	JJ
cord-015021-pol2qm74	4458	21	value	value	NN
cord-015021-pol2qm74	4458	22	of	of	IN
cord-015021-pol2qm74	4458	23	0.795	0.795	CD
cord-015021-pol2qm74	4458	24	EU	EU	NNP
cord-015021-pol2qm74	4458	25	/	/	SYM
cord-015021-pol2qm74	4458	26	m	m	NN
cord-015021-pol2qm74	4458	27	!	!	.
cord-015021-pol2qm74	4458	28	)	)	-RRB-
cord-015021-pol2qm74	4459	1	during	during	IN
cord-015021-pol2qm74	4459	2	reperfusicn	reperfusicn	NNP
cord-015021-pol2qm74	4459	3	.	.	.
cord-015021-pol2qm74	4460	1	Plasma	plasma	NN
cord-015021-pol2qm74	4460	2	levels	level	NNS
cord-015021-pol2qm74	4460	3	of	of	IN
cord-015021-pol2qm74	4460	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4460	5	continued	continue	VBD
cord-015021-pol2qm74	4460	6	to	to	TO
cord-015021-pol2qm74	4460	7	be	be	VB
cord-015021-pol2qm74	4460	8	slightly	slightly	RB
cord-015021-pol2qm74	4460	9	raised	raise	VBN
cord-015021-pol2qm74	4460	10	till	till	IN
cord-015021-pol2qm74	4460	11	the	the	DT
cord-015021-pol2qm74	4460	12	5th	5th	JJ
cord-015021-pol2qm74	4460	13	day	day	NN
cord-015021-pol2qm74	4460	14	after	after	IN
cord-015021-pol2qm74	4460	15	surgery	surgery	NN
cord-015021-pol2qm74	4460	16	,	,	,
cord-015021-pol2qm74	4460	17	whereas	whereas	IN
cord-015021-pol2qm74	4460	18	those	those	DT
cord-015021-pol2qm74	4460	19	of	of	IN
cord-015021-pol2qm74	4460	20	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	4460	21	rose	rise	VBD
cord-015021-pol2qm74	4460	22	at	at	IN
cord-015021-pol2qm74	4460	23	the	the	DT
cord-015021-pol2qm74	4460	24	end	end	NN
cord-015021-pol2qm74	4460	25	of	of	IN
cord-015021-pol2qm74	4460	26	the	the	DT
cord-015021-pol2qm74	4460	27	operation	operation	NN
cord-015021-pol2qm74	4460	28	and	and	CC
cord-015021-pol2qm74	4460	29	were	be	VBD
cord-015021-pol2qm74	4460	30	at	at	IN
cord-015021-pol2qm74	4460	31	their	-PRON-	PRP$
cord-015021-pol2qm74	4460	32	highest	high	JJS
cord-015021-pol2qm74	4460	33	4	4	CD
cord-015021-pol2qm74	4460	34	hours	hour	NNS
cord-015021-pol2qm74	4460	35	later	later	RB
cord-015021-pol2qm74	4460	36	(	(	-LRB-
cord-015021-pol2qm74	4460	37	median	median	JJ
cord-015021-pol2qm74	4460	38	value	value	NN
cord-015021-pol2qm74	4460	39	of	of	IN
cord-015021-pol2qm74	4460	40	217.5	217.5	CD
cord-015021-pol2qm74	4460	41	pg	pg	NNP
cord-015021-pol2qm74	4460	42	/	/	SYM
cord-015021-pol2qm74	4460	43	ml	ml	NNP
cord-015021-pol2qm74	4460	44	)	)	-RRB-
cord-015021-pol2qm74	4460	45	.	.	.
cord-015021-pol2qm74	4461	1	CRP	CRP	NNP
cord-015021-pol2qm74	4461	2	levels	level	NNS
cord-015021-pol2qm74	4461	3	were	be	VBD
cord-015021-pol2qm74	4461	4	also	also	RB
cord-015021-pol2qm74	4461	5	high	high	JJ
cord-015021-pol2qm74	4461	6	postoperatively	postoperatively	RB
cord-015021-pol2qm74	4461	7	with	with	IN
cord-015021-pol2qm74	4461	8	a	a	DT
cord-015021-pol2qm74	4461	9	median	median	JJ
cord-015021-pol2qm74	4461	10	value	value	NN
cord-015021-pol2qm74	4461	11	of	of	IN
cord-015021-pol2qm74	4461	12	114	114	CD
cord-015021-pol2qm74	4461	13	mg	mg	NNP
cord-015021-pol2qm74	4461	14	/	/	SYM
cord-015021-pol2qm74	4461	15	l	l	NNP
cord-015021-pol2qm74	4461	16	,	,	,
cord-015021-pol2qm74	4461	17	and	and	CC
cord-015021-pol2qm74	4461	18	were	be	VBD
cord-015021-pol2qm74	4461	19	markedly	markedly	RB
cord-015021-pol2qm74	4461	20	raised	raise	VBN
cord-015021-pol2qm74	4461	21	on	on	IN
cord-015021-pol2qm74	4461	22	day	day	NN
cord-015021-pol2qm74	4461	23	2	2	CD
cord-015021-pol2qm74	4461	24	(	(	-LRB-
cord-015021-pol2qm74	4461	25	191	191	CD
cord-015021-pol2qm74	4461	26	mg	mg	NNP
cord-015021-pol2qm74	4461	27	/	/	SYM
cord-015021-pol2qm74	4461	28	l	l	NN
cord-015021-pol2qm74	4461	29	)	)	-RRB-
cord-015021-pol2qm74	4461	30	.	.	.
cord-015021-pol2qm74	4462	1	A	a	DT
cord-015021-pol2qm74	4462	2	definite	definite	JJ
cord-015021-pol2qm74	4462	3	,	,	,
cord-015021-pol2qm74	4462	4	statistically	statistically	RB
cord-015021-pol2qm74	4462	5	significant	significant	JJ
cord-015021-pol2qm74	4462	6	correlation	correlation	NN
cord-015021-pol2qm74	4462	7	between	between	IN
cord-015021-pol2qm74	4462	8	the	the	DT
cord-015021-pol2qm74	4462	9	plasma	plasma	NN
cord-015021-pol2qm74	4462	10	levels	level	NNS
cord-015021-pol2qm74	4462	11	of	of	IN
cord-015021-pol2qm74	4462	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4462	13	and	and	CC
cord-015021-pol2qm74	4462	14	11	11	CD
cord-015021-pol2qm74	4462	15	-	-	SYM
cord-015021-pol2qm74	4462	16	6	6	CD
cord-015021-pol2qm74	4462	17	during	during	IN
cord-015021-pol2qm74	4462	18	the	the	DT
cord-015021-pol2qm74	4462	19	operation	operation	NN
cord-015021-pol2qm74	4462	20	was	be	VBD
cord-015021-pol2qm74	4462	21	establisthed	establisthe	VBN
cord-015021-pol2qm74	4462	22	(	(	-LRB-
cord-015021-pol2qm74	4462	23	p	p	NN
cord-015021-pol2qm74	4462	24	0.05	0.05	CD
cord-015021-pol2qm74	4462	25	)	)	-RRB-
cord-015021-pol2qm74	4462	26	,	,	,
cord-015021-pol2qm74	4462	27	leading	lead	VBG
cord-015021-pol2qm74	4462	28	us	-PRON-	PRP
cord-015021-pol2qm74	4462	29	to	to	TO
cord-015021-pol2qm74	4462	30	conclude	conclude	VB
cord-015021-pol2qm74	4462	31	that	that	IN
cord-015021-pol2qm74	4462	32	the	the	DT
cord-015021-pol2qm74	4462	33	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4462	34	liberated	liberate	VBN
cord-015021-pol2qm74	4462	35	during	during	IN
cord-015021-pol2qm74	4462	36	cardiac	cardiac	JJ
cord-015021-pol2qm74	4462	37	surgery	surgery	NN
cord-015021-pol2qm74	4462	38	acts	act	NNS
cord-015021-pol2qm74	4462	39	as	as	IN
cord-015021-pol2qm74	4462	40	the	the	DT
cord-015021-pol2qm74	4462	41	main	main	JJ
cord-015021-pol2qm74	4462	42	trigger	trigger	NN
cord-015021-pol2qm74	4462	43	in	in	IN
cord-015021-pol2qm74	4462	44	the	the	DT
cord-015021-pol2qm74	4462	45	releasing	releasing	NN
cord-015021-pol2qm74	4462	46	of	of	IN
cord-015021-pol2qm74	4462	47	11	11	CD
cord-015021-pol2qm74	4462	48	-	-	SYM
cord-015021-pol2qm74	4462	49	6	6	CD
cord-015021-pol2qm74	4462	50	,	,	,
cord-015021-pol2qm74	4462	51	and	and	CC
cord-015021-pol2qm74	4462	52	thus	thus	RB
cord-015021-pol2qm74	4462	53	induces	induce	VBZ
cord-015021-pol2qm74	4462	54	the	the	DT
cord-015021-pol2qm74	4462	55	postoperative	postoperative	JJ
cord-015021-pol2qm74	4462	56	acute	acute	JJ
cord-015021-pol2qm74	4462	57	phase	phase	NN
cord-015021-pol2qm74	4462	58	reaction	reaction	NN
cord-015021-pol2qm74	4462	59	.	.	.
cord-015021-pol2qm74	4463	1	There	there	EX
cord-015021-pol2qm74	4463	2	was	be	VBD
cord-015021-pol2qm74	4463	3	no	no	DT
cord-015021-pol2qm74	4463	4	evidence	evidence	NN
cord-015021-pol2qm74	4463	5	of	of	IN
cord-015021-pol2qm74	4463	6	a	a	DT
cord-015021-pol2qm74	4463	7	correlation	correlation	NN
cord-015021-pol2qm74	4463	8	between	between	IN
cord-015021-pol2qm74	4463	9	CRP	crp	NN
cord-015021-pol2qm74	4463	10	and	and	CC
cord-015021-pol2qm74	4463	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4463	12	or	or	CC
cord-015021-pol2qm74	4463	13	11	11	CD
cord-015021-pol2qm74	4463	14	-	-	SYM
cord-015021-pol2qm74	4463	15	6	6	CD
cord-015021-pol2qm74	4463	16	plasma	plasma	NN
cord-015021-pol2qm74	4463	17	levels	level	NNS
cord-015021-pol2qm74	4463	18	.	.	.
cord-015021-pol2qm74	4464	1	Impaired	impaired	JJ
cord-015021-pol2qm74	4464	2	immune	immune	JJ
cord-015021-pol2qm74	4464	3	function	function	NN
cord-015021-pol2qm74	4464	4	is	be	VBZ
cord-015021-pol2qm74	4464	5	well	well	RB
cord-015021-pol2qm74	4464	6	described	describe	VBN
cord-015021-pol2qm74	4464	7	following	follow	VBG
cord-015021-pol2qm74	4464	8	trauma	trauma	NN
cord-015021-pol2qm74	4464	9	and	and	CC
cord-015021-pol2qm74	4464	10	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	4464	11	shock	shock	NN
cord-015021-pol2qm74	4464	12	(	(	-LRB-
cord-015021-pol2qm74	4464	13	HS	HS	NNP
cord-015021-pol2qm74	4464	14	)	)	-RRB-
cord-015021-pol2qm74	4464	15	.	.	.
cord-015021-pol2qm74	4465	1	Prior	prior	JJ
cord-015021-pol2qm74	4465	2	studies	study	NNS
cord-015021-pol2qm74	4465	3	have	have	VBP
cord-015021-pol2qm74	4465	4	utilized	utilize	VBN
cord-015021-pol2qm74	4465	5	peripheral	peripheral	JJ
cord-015021-pol2qm74	4465	6	blood	blood	NN
cord-015021-pol2qm74	4465	7	or	or	CC
cord-015021-pol2qm74	4465	8	spleen	spleen	NN
cord-015021-pol2qm74	4465	9	cells	cell	NNS
cord-015021-pol2qm74	4465	10	to	to	IN
cord-015021-pol2qm74	4465	11	index	index	NN
cord-015021-pol2qm74	4465	12	immune	immune	JJ
cord-015021-pol2qm74	4465	13	function	function	NN
cord-015021-pol2qm74	4465	14	following	follow	VBG
cord-015021-pol2qm74	4465	15	HS	HS	NNP
cord-015021-pol2qm74	4465	16	.	.	.
cord-015021-pol2qm74	4466	1	However	however	RB
cord-015021-pol2qm74	4466	2	,	,	,
cord-015021-pol2qm74	4466	3	changes	change	NNS
cord-015021-pol2qm74	4466	4	in	in	IN
cord-015021-pol2qm74	4466	5	mucosal	mucosal	JJ
cord-015021-pol2qm74	4466	6	immunity	immunity	NN
cord-015021-pol2qm74	4466	7	are	be	VBP
cord-015021-pol2qm74	4466	8	not	not	RB
cord-015021-pol2qm74	4466	9	weII	weII	NNP
cord-015021-pol2qm74	4466	10	characterized	characterize	VBN
cord-015021-pol2qm74	4466	11	in	in	IN
cord-015021-pol2qm74	4466	12	this	this	DT
cord-015021-pol2qm74	4466	13	setting	setting	NN
cord-015021-pol2qm74	4466	14	.	.	.
cord-015021-pol2qm74	4467	1	Gut	gut	JJ
cord-015021-pol2qm74	4467	2	origin	origin	NN
cord-015021-pol2qm74	4467	3	sepsis	sepsis	NN
cord-015021-pol2qm74	4467	4	is	be	VBZ
cord-015021-pol2qm74	4467	5	thought	think	VBN
cord-015021-pol2qm74	4467	6	to	to	TO
cord-015021-pol2qm74	4467	7	be	be	VB
cord-015021-pol2qm74	4467	8	an	an	DT
cord-015021-pol2qm74	4467	9	important	important	JJ
cord-015021-pol2qm74	4467	10	cause	cause	NN
cord-015021-pol2qm74	4467	11	of	of	IN
cord-015021-pol2qm74	4467	12	organ	organ	NN
cord-015021-pol2qm74	4467	13	failure	failure	NN
cord-015021-pol2qm74	4467	14	and	and	CC
cord-015021-pol2qm74	4467	15	death	death	NN
cord-015021-pol2qm74	4467	16	following	follow	VBG
cord-015021-pol2qm74	4467	17	trauma	trauma	NN
cord-015021-pol2qm74	4467	18	.	.	.
cord-015021-pol2qm74	4468	1	A	a	DT
cord-015021-pol2qm74	4468	2	rodent	rodent	NN
cord-015021-pol2qm74	4468	3	model	model	NN
cord-015021-pol2qm74	4468	4	was	be	VBD
cord-015021-pol2qm74	4468	5	utilized	utilize	VBN
cord-015021-pol2qm74	4468	6	to	to	TO
cord-015021-pol2qm74	4468	7	allow	allow	VB
cord-015021-pol2qm74	4468	8	comparison	comparison	NN
cord-015021-pol2qm74	4468	9	of	of	IN
cord-015021-pol2qm74	4468	10	mucosal	mucosal	JJ
cord-015021-pol2qm74	4468	11	-	-	HYPH
cord-015021-pol2qm74	4468	12	associated	associated	JJ
cord-015021-pol2qm74	4468	13	immune	immune	JJ
cord-015021-pol2qm74	4468	14	function	function	NN
cord-015021-pol2qm74	4468	15	vs	vs	IN
cord-015021-pol2qm74	4468	16	,	,	,
cord-015021-pol2qm74	4468	17	systemic	systemic	JJ
cord-015021-pol2qm74	4468	18	compartments	compartment	NNS
cord-015021-pol2qm74	4468	19	after	after	IN
cord-015021-pol2qm74	4468	20	HS	HS	NNP
cord-015021-pol2qm74	4468	21	.	.	.
cord-015021-pol2qm74	4469	1	Fischer	Fischer	NNP
cord-015021-pol2qm74	4469	2	rates	rate	NNS
cord-015021-pol2qm74	4469	3	underwent	undergo	VBD
cord-015021-pol2qm74	4469	4	HS	HS	NNP
cord-015021-pol2qm74	4469	5	(	(	-LRB-
cord-015021-pol2qm74	4469	6	MAP	MAP	NNP
cord-015021-pol2qm74	4469	7	35±5	35±5	CD
cord-015021-pol2qm74	4469	8	mm	mm	CD
cord-015021-pol2qm74	4469	9	Hg	Hg	NNP
cord-015021-pol2qm74	4469	10	)	)	-RRB-
cord-015021-pol2qm74	4469	11	for	for	IN
cord-015021-pol2qm74	4469	12	60	60	CD
cord-015021-pol2qm74	4469	13	minutes	minute	NNS
cord-015021-pol2qm74	4469	14	followed	follow	VBN
cord-015021-pol2qm74	4469	15	by	by	IN
cord-015021-pol2qm74	4469	16	resuscitation	resuscitation	NN
cord-015021-pol2qm74	4469	17	with	with	IN
cord-015021-pol2qm74	4469	18	shed	shed	JJ
cord-015021-pol2qm74	4469	19	blood	blood	NN
cord-015021-pol2qm74	4469	20	and	and	CC
cord-015021-pol2qm74	4469	21	LR	LR	NNP
cord-015021-pol2qm74	4469	22	.	.	.
cord-015021-pol2qm74	4470	1	Sham	sham	JJ
cord-015021-pol2qm74	4470	2	animals	animal	NNS
cord-015021-pol2qm74	4470	3	were	be	VBD
cord-015021-pol2qm74	4470	4	instrumented	instrument	VBN
cord-015021-pol2qm74	4470	5	only	only	RB
cord-015021-pol2qm74	4470	6	.	.	.
cord-015021-pol2qm74	4471	1	Rat	rat	NN
cord-015021-pol2qm74	4471	2	tears	tear	NNS
cord-015021-pol2qm74	4471	3	were	be	VBD
cord-015021-pol2qm74	4471	4	collected	collect	VBN
cord-015021-pol2qm74	4471	5	at	at	IN
cord-015021-pol2qm74	4471	6	24	24	CD
cord-015021-pol2qm74	4471	7	and	and	CC
cord-015021-pol2qm74	4471	8	72	72	CD
cord-015021-pol2qm74	4471	9	hours	hour	NNS
cord-015021-pol2qm74	4471	10	following	follow	VBG
cord-015021-pol2qm74	4471	11	HS	HS	NNP
cord-015021-pol2qm74	4471	12	for	for	IN
cord-015021-pol2qm74	4471	13	quantitation	quantitation	NN
cord-015021-pol2qm74	4471	14	of	of	IN
cord-015021-pol2qm74	4471	15	slgA	slga	NN
cord-015021-pol2qm74	4471	16	by	by	IN
cord-015021-pol2qm74	4471	17	RIA	RIA	NNP
cord-015021-pol2qm74	4471	18	.	.	.
cord-015021-pol2qm74	4472	1	Animals	animal	NNS
cord-015021-pol2qm74	4472	2	were	be	VBD
cord-015021-pol2qm74	4472	3	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	4472	4	at	at	IN
cord-015021-pol2qm74	4472	5	24	24	CD
cord-015021-pol2qm74	4472	6	hours	hour	NNS
cord-015021-pol2qm74	4472	7	and	and	CC
cord-015021-pol2qm74	4472	8	spleen	spleen	NNS
cord-015021-pol2qm74	4472	9	(	(	-LRB-
cord-015021-pol2qm74	4472	10	SPL	SPL	NNP
cord-015021-pol2qm74	4472	11	)	)	-RRB-
cord-015021-pol2qm74	4472	12	,	,	,
cord-015021-pol2qm74	4472	13	peripheral	peripheral	JJ
cord-015021-pol2qm74	4472	14	lymph	lymph	NN
cord-015021-pol2qm74	4472	15	nodes	node	NNS
cord-015021-pol2qm74	4472	16	(	(	-LRB-
cord-015021-pol2qm74	4472	17	PLN	PLN	NNP
cord-015021-pol2qm74	4472	18	)	)	-RRB-
cord-015021-pol2qm74	4472	19	,	,	,
cord-015021-pol2qm74	4472	20	and	and	CC
cord-015021-pol2qm74	4472	21	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	4472	22	lymph	lymph	NN
cord-015021-pol2qm74	4472	23	nodes	node	NNS
cord-015021-pol2qm74	4472	24	(	(	-LRB-
cord-015021-pol2qm74	4472	25	MLN	mln	NN
cord-015021-pol2qm74	4472	26	)	)	-RRB-
cord-015021-pol2qm74	4472	27	harvested	harvest	VBN
cord-015021-pol2qm74	4472	28	for	for	IN
cord-015021-pol2qm74	4472	29	cell	cell	NN
cord-015021-pol2qm74	4472	30	population	population	NN
cord-015021-pol2qm74	4472	31	analysis	analysis	NN
cord-015021-pol2qm74	4472	32	using	use	VBG
cord-015021-pol2qm74	4472	33	flow	flow	NN
cord-015021-pol2qm74	4472	34	cytometry	cytometry	NN
cord-015021-pol2qm74	4472	35	and	and	CC
cord-015021-pol2qm74	4472	36	mitogen	mitogen	NN
cord-015021-pol2qm74	4472	37	stimulation	stimulation	NN
cord-015021-pol2qm74	4472	38	analysis	analysis	NN
cord-015021-pol2qm74	4472	39	.	.	.
cord-015021-pol2qm74	4473	1	Cell	cell	NN
cord-015021-pol2qm74	4473	2	marker	marker	NN
cord-015021-pol2qm74	4473	3	expression	expression	NN
cord-015021-pol2qm74	4473	4	analysis	analysis	NN
cord-015021-pol2qm74	4473	5	revealed	reveal	VBD
cord-015021-pol2qm74	4473	6	no	no	DT
cord-015021-pol2qm74	4473	7	changes	change	NNS
cord-015021-pol2qm74	4473	8	in	in	IN
cord-015021-pol2qm74	4473	9	T	T	NNP
cord-015021-pol2qm74	4473	10	or	or	CC
cord-015021-pol2qm74	4473	11	B	B	NNP
cord-015021-pol2qm74	4473	12	ceil	ceil	NN
cord-015021-pol2qm74	4473	13	populations	population	NNS
cord-015021-pol2qm74	4473	14	following	follow	VBG
cord-015021-pol2qm74	4473	15	HS	HS	NNP
cord-015021-pol2qm74	4473	16	.	.	.
cord-015021-pol2qm74	4474	1	Mitogen	Mitogen	NNP
cord-015021-pol2qm74	4474	2	Mucosal	Mucosal	NNP
cord-015021-pol2qm74	4474	3	immune	immune	JJ
cord-015021-pol2qm74	4474	4	function	function	NN
cord-015021-pol2qm74	4474	5	appears	appear	VBZ
cord-015021-pol2qm74	4474	6	relatively	relatively	RB
cord-015021-pol2qm74	4474	7	spared	spared	JJ
cord-015021-pol2qm74	4474	8	following	follow	VBG
cord-015021-pol2qm74	4474	9	HS	HS	NNP
cord-015021-pol2qm74	4474	10	.	.	.
cord-015021-pol2qm74	4475	1	The	the	DT
cord-015021-pol2qm74	4475	2	mechanism(s	mechanism(s	NNP
cord-015021-pol2qm74	4475	3	)	)	-RRB-
cord-015021-pol2qm74	4475	4	for	for	IN
cord-015021-pol2qm74	4475	5	this	this	DT
cord-015021-pol2qm74	4475	6	variability	variability	NN
cord-015021-pol2qm74	4475	7	in	in	IN
cord-015021-pol2qm74	4475	8	immune	immune	JJ
cord-015021-pol2qm74	4475	9	function	function	NN
cord-015021-pol2qm74	4475	10	requires	require	VBZ
cord-015021-pol2qm74	4475	11	further	further	JJ
cord-015021-pol2qm74	4475	12	investigation	investigation	NN
cord-015021-pol2qm74	4475	13	.	.	.
cord-015021-pol2qm74	4476	1	We	-PRON-	PRP
cord-015021-pol2qm74	4476	2	have	have	VBP
cord-015021-pol2qm74	4476	3	found	find	VBN
cord-015021-pol2qm74	4476	4	that	that	IN
cord-015021-pol2qm74	4476	5	transplantation	transplantation	NN
cord-015021-pol2qm74	4476	6	of	of	IN
cord-015021-pol2qm74	4476	7	bone	bone	NN
cord-015021-pol2qm74	4476	8	marrow	marrow	NN
cord-015021-pol2qm74	4476	9	in	in	IN
cord-015021-pol2qm74	4476	10	a	a	DT
cord-015021-pol2qm74	4476	11	hind	hind	JJ
cord-015021-pol2qm74	4476	12	-	-	HYPH
cord-015021-pol2qm74	4476	13	limb	limb	NN
cord-015021-pol2qm74	4476	14	graft	graft	NN
cord-015021-pol2qm74	4476	15	to	to	IN
cord-015021-pol2qm74	4476	16	syngeneic	syngeneic	NNS
cord-015021-pol2qm74	4476	17	lethally	lethally	RB
cord-015021-pol2qm74	4476	18	irradiated	irradiate	VBD
cord-015021-pol2qm74	4476	19	recipient	recipient	NN
cord-015021-pol2qm74	4476	20	is	be	VBZ
cord-015021-pol2qm74	4476	21	followed	follow	VBN
cord-015021-pol2qm74	4476	22	not	not	RB
cord-015021-pol2qm74	4476	23	only	only	RB
cord-015021-pol2qm74	4476	24	by	by	IN
cord-015021-pol2qm74	4476	25	rapid	rapid	JJ
cord-015021-pol2qm74	4476	26	repopulafion	repopulafion	NN
cord-015021-pol2qm74	4476	27	but	but	CC
cord-015021-pol2qm74	4476	28	also	also	RB
cord-015021-pol2qm74	4476	29	overpopulation	overpopulation	NN
cord-015021-pol2qm74	4476	30	of	of	IN
cord-015021-pol2qm74	4476	31	bone	bone	NN
cord-015021-pol2qm74	4476	32	marrow	marrow	NN
cord-015021-pol2qm74	4476	33	cavities	cavity	NNS
cord-015021-pol2qm74	4476	34	.	.	.
cord-015021-pol2qm74	4477	1	The	the	DT
cord-015021-pol2qm74	4477	2	question	question	NN
cord-015021-pol2qm74	4477	3	arises	arise	VBZ
cord-015021-pol2qm74	4477	4	whether	whether	IN
cord-015021-pol2qm74	4477	5	this	this	DT
cord-015021-pol2qm74	4477	6	unexpected	unexpected	JJ
cord-015021-pol2qm74	4477	7	phenomenon	phenomenon	NN
cord-015021-pol2qm74	4477	8	could	could	MD
cord-015021-pol2qm74	4477	9	be	be	VB
cord-015021-pol2qm74	4477	10	the	the	DT
cord-015021-pol2qm74	4477	11	result	result	NN
cord-015021-pol2qm74	4477	12	of	of	IN
cord-015021-pol2qm74	4477	13	stimulation	stimulation	NN
cord-015021-pol2qm74	4477	14	of	of	IN
cord-015021-pol2qm74	4477	15	stem	stem	NN
cord-015021-pol2qm74	4477	16	cells	cell	NNS
cord-015021-pol2qm74	4477	17	by	by	IN
cord-015021-pol2qm74	4477	18	factors	factor	NNS
cord-015021-pol2qm74	4477	19	(	(	-LRB-
cord-015021-pol2qm74	4477	20	cytokines	cytokine	NNS
cord-015021-pol2qm74	4477	21	)	)	-RRB-
cord-015021-pol2qm74	4477	22	released	release	VBN
cord-015021-pol2qm74	4477	23	from	from	IN
cord-015021-pol2qm74	4477	24	surgical	surgical	JJ
cord-015021-pol2qm74	4477	25	wound	wound	NN
cord-015021-pol2qm74	4477	26	at	at	IN
cord-015021-pol2qm74	4477	27	the	the	DT
cord-015021-pol2qm74	4477	28	site	site	NN
cord-015021-pol2qm74	4477	29	of	of	IN
cord-015021-pol2qm74	4477	30	anastomosis	anastomosis	NN
cord-015021-pol2qm74	4477	31	of	of	IN
cord-015021-pol2qm74	4477	32	graft	graft	NN
cord-015021-pol2qm74	4477	33	with	with	IN
cord-015021-pol2qm74	4477	34	recipient	recipient	NN
cord-015021-pol2qm74	4477	35	.	.	.
cord-015021-pol2qm74	4478	1	AIM	aim	VB
cord-015021-pol2qm74	4478	2	OF	of	IN
cord-015021-pol2qm74	4478	3	THE	the	DT
cord-015021-pol2qm74	4478	4	STUDY	study	NN
cord-015021-pol2qm74	4478	5	was	be	VBD
cord-015021-pol2qm74	4478	6	to	to	TO
cord-015021-pol2qm74	4478	7	investigate	investigate	VB
cord-015021-pol2qm74	4478	8	which	which	WDT
cord-015021-pol2qm74	4478	9	tissues	tissue	NNS
cord-015021-pol2qm74	4478	10	damaged	damage	VBN
cord-015021-pol2qm74	4478	11	during	during	IN
cord-015021-pol2qm74	4478	12	the	the	DT
cord-015021-pol2qm74	4478	13	procedure	procedure	NN
cord-015021-pol2qm74	4478	14	of	of	IN
cord-015021-pol2qm74	4478	15	limb	limb	NN
cord-015021-pol2qm74	4478	16	transplantation	transplantation	NN
cord-015021-pol2qm74	4478	17	may	may	MD
cord-015021-pol2qm74	4478	18	be	be	VB
cord-015021-pol2qm74	4478	19	a	a	DT
cord-015021-pol2qm74	4478	20	potential	potential	JJ
cord-015021-pol2qm74	4478	21	source	source	NN
cord-015021-pol2qm74	4478	22	of	of	IN
cord-015021-pol2qm74	4478	23	humoral	humoral	JJ
cord-015021-pol2qm74	4478	24	factors	factor	NNS
cord-015021-pol2qm74	4478	25	accelerating	accelerate	VBG
cord-015021-pol2qm74	4478	26	in	in	IN
cord-015021-pol2qm74	4478	27	vivo	vivo	NN
cord-015021-pol2qm74	4478	28	bone	bone	NN
cord-015021-pol2qm74	4478	29	marrow	marrow	NN
cord-015021-pol2qm74	4478	30	proliferation	proliferation	NN
cord-015021-pol2qm74	4478	31	.	.	.
cord-015021-pol2qm74	4479	1	METHODS	METHODS	NNP
cord-015021-pol2qm74	4479	2	.	.	.
cord-015021-pol2qm74	4480	1	Experiments	experiment	NNS
cord-015021-pol2qm74	4480	2	were	be	VBD
cord-015021-pol2qm74	4480	3	carried	carry	VBN
cord-015021-pol2qm74	4480	4	out	out	RP
cord-015021-pol2qm74	4480	5	on	on	IN
cord-015021-pol2qm74	4480	6	LEW	LEW	NNP
cord-015021-pol2qm74	4480	7	rats	rat	NNS
cord-015021-pol2qm74	4480	8	in	in	IN
cord-015021-pol2qm74	4480	9	5	5	CD
cord-015021-pol2qm74	4480	10	groups	group	NNS
cord-015021-pol2qm74	4480	11	.	.	.
cord-015021-pol2qm74	4481	1	In	in	IN
cord-015021-pol2qm74	4481	2	group	group	NN
cord-015021-pol2qm74	4481	3	I	-PRON-	PRP
cord-015021-pol2qm74	4481	4	,	,	,
cord-015021-pol2qm74	4481	5	the	the	DT
cord-015021-pol2qm74	4481	6	hind	hind	NN
cord-015021-pol2qm74	4481	7	limb	limb	NN
cord-015021-pol2qm74	4481	8	was	be	VBD
cord-015021-pol2qm74	4481	9	transplanted	transplant	VBN
cord-015021-pol2qm74	4481	10	orthotopically	orthotopically	RB
cord-015021-pol2qm74	4481	11	to	to	IN
cord-015021-pol2qm74	4481	12	a	a	DT
cord-015021-pol2qm74	4481	13	syngeneic	syngeneic	NNS
cord-015021-pol2qm74	4481	14	recipient	recipient	NN
cord-015021-pol2qm74	4481	15	;	;	:
cord-015021-pol2qm74	4481	16	in	in	IN
cord-015021-pol2qm74	4481	17	group	group	NN
cord-015021-pol2qm74	4481	18	II	II	NNP
cord-015021-pol2qm74	4481	19	,	,	,
cord-015021-pol2qm74	4481	20	sham	sham	NN
cord-015021-pol2qm74	4481	21	operation	operation	NN
cord-015021-pol2qm74	4481	22	was	be	VBD
cord-015021-pol2qm74	4481	23	performed	perform	VBN
cord-015021-pol2qm74	4481	24	;	;	:
cord-015021-pol2qm74	4481	25	in	in	IN
cord-015021-pol2qm74	4481	26	group	group	NN
cord-015021-pol2qm74	4481	27	III	III	NNP
cord-015021-pol2qm74	4481	28	,	,	,
cord-015021-pol2qm74	4481	29	a	a	DT
cord-015021-pol2qm74	4481	30	four	four	CD
cord-015021-pol2qm74	4481	31	-	-	HYPH
cord-015021-pol2qm74	4481	32	cm	cm	NN
cord-015021-pol2qm74	4481	33	long	long	JJ
cord-015021-pol2qm74	4481	34	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	4481	35	wound	wound	NN
cord-015021-pol2qm74	4481	36	was	be	VBD
cord-015021-pol2qm74	4481	37	made	make	VBN
cord-015021-pol2qm74	4481	38	on	on	IN
cord-015021-pol2qm74	4481	39	the	the	DT
cord-015021-pol2qm74	4481	40	dorsum	dorsum	NN
cord-015021-pol2qm74	4481	41	;	;	:
cord-015021-pol2qm74	4481	42	in	in	IN
cord-015021-pol2qm74	4481	43	group	group	NN
cord-015021-pol2qm74	4481	44	IV	IV	NNP
cord-015021-pol2qm74	4481	45	,	,	,
cord-015021-pol2qm74	4481	46	limb	limb	NN
cord-015021-pol2qm74	4481	47	skin	skin	NN
cord-015021-pol2qm74	4481	48	was	be	VBD
cord-015021-pol2qm74	4481	49	harvested	harvest	VBN
cord-015021-pol2qm74	4481	50	,	,	,
cord-015021-pol2qm74	4481	51	fragmented	fragmented	JJ
cord-015021-pol2qm74	4481	52	and	and	CC
cord-015021-pol2qm74	4481	53	implanted	implant	VBN
cord-015021-pol2qm74	4481	54	into	into	IN
cord-015021-pol2qm74	4481	55	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4481	56	cavity	cavity	NN
cord-015021-pol2qm74	4481	57	;	;	:
cord-015021-pol2qm74	4481	58	in	in	IN
cord-015021-pol2qm74	4481	59	group	group	NN
cord-015021-pol2qm74	4481	60	V	v	NN
cord-015021-pol2qm74	4481	61	,	,	,
cord-015021-pol2qm74	4481	62	BM	BM	NNP
cord-015021-pol2qm74	4481	63	from	from	IN
cord-015021-pol2qm74	4481	64	femur	femur	NN
cord-015021-pol2qm74	4481	65	and	and	CC
cord-015021-pol2qm74	4481	66	tibia	tibia	NN
cord-015021-pol2qm74	4481	67	was	be	VBD
cord-015021-pol2qm74	4481	68	implanted	implant	VBN
cord-015021-pol2qm74	4481	69	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	4481	70	.	.	.
cord-015021-pol2qm74	4482	1	BM	BM	NNP
cord-015021-pol2qm74	4482	2	,	,	,
cord-015021-pol2qm74	4482	3	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	4482	4	tissues	tissue	NNS
cord-015021-pol2qm74	4482	5	and	and	CC
cord-015021-pol2qm74	4482	6	blood	blood	NN
cord-015021-pol2qm74	4482	7	were	be	VBD
cord-015021-pol2qm74	4482	8	sampled	sample	VBN
cord-015021-pol2qm74	4482	9	10	10	CD
cord-015021-pol2qm74	4482	10	and	and	CC
cord-015021-pol2qm74	4482	11	30	30	CD
cord-015021-pol2qm74	4482	12	days	day	NNS
cord-015021-pol2qm74	4482	13	later	later	RB
cord-015021-pol2qm74	4482	14	for	for	IN
cord-015021-pol2qm74	4482	15	cell	cell	NN
cord-015021-pol2qm74	4482	16	concentration	concentration	NN
cord-015021-pol2qm74	4482	17	and	and	CC
cord-015021-pol2qm74	4482	18	phenotype	phenotype	NN
cord-015021-pol2qm74	4482	19	evaluation	evaluation	NN
cord-015021-pol2qm74	4482	20	.	.	.
cord-015021-pol2qm74	4483	1	RESULTS	result	NNS
cord-015021-pol2qm74	4483	2	.	.	.
cord-015021-pol2qm74	4484	1	The	the	DT
cord-015021-pol2qm74	4484	2	yield	yield	NN
cord-015021-pol2qm74	4484	3	of	of	IN
cord-015021-pol2qm74	4484	4	nucleated	nucleated	JJ
cord-015021-pol2qm74	4484	5	cells	cell	NNS
cord-015021-pol2qm74	4484	6	from	from	IN
cord-015021-pol2qm74	4484	7	tibia	tibia	NN
cord-015021-pol2qm74	4484	8	was	be	VBD
cord-015021-pol2qm74	4484	9	on	on	IN
cord-015021-pol2qm74	4484	10	day	day	NN
cord-015021-pol2qm74	4484	11	10	10	CD
cord-015021-pol2qm74	4484	12	in	in	IN
cord-015021-pol2qm74	4484	13	the	the	DT
cord-015021-pol2qm74	4484	14	control	control	NN
cord-015021-pol2qm74	4484	15	29.3	29.3	CD
cord-015021-pol2qm74	4484	16	+	+	SYM
cord-015021-pol2qm74	4484	17	3.2	3.2	CD
cord-015021-pol2qm74	4484	18	,	,	,
cord-015021-pol2qm74	4484	19	in	in	IN
cord-015021-pol2qm74	4484	20	group	group	NN
cord-015021-pol2qm74	4484	21	1	1	CD
cord-015021-pol2qm74	4484	22	58.1	58.1	CD
cord-015021-pol2qm74	4484	23	+2.0	+2.0	NNP
cord-015021-pol2qm74	4484	24	,	,	,
cord-015021-pol2qm74	4484	25	in	in	IN
cord-015021-pol2qm74	4484	26	group	group	NN
cord-015021-pol2qm74	4484	27	II	II	NNP
cord-015021-pol2qm74	4484	28	47.1	47.1	CD
cord-015021-pol2qm74	4484	29	+	+	SYM
cord-015021-pol2qm74	4484	30	1.6	1.6	CD
cord-015021-pol2qm74	4484	31	,	,	,
cord-015021-pol2qm74	4484	32	in	in	IN
cord-015021-pol2qm74	4484	33	group	group	NN
cord-015021-pol2qm74	4484	34	III	iii	CD
cord-015021-pol2qm74	4484	35	50.8	50.8	CD
cord-015021-pol2qm74	4484	36	+	+	SYM
cord-015021-pol2qm74	4484	37	2.0	2.0	CD
cord-015021-pol2qm74	4484	38	,	,	,
cord-015021-pol2qm74	4484	39	in	in	IN
cord-015021-pol2qm74	4484	40	group	group	NN
cord-015021-pol2qm74	4484	41	IV	IV	NNP
cord-015021-pol2qm74	4484	42	48.5_+2.0	48.5_+2.0	CD
cord-015021-pol2qm74	4484	43	,	,	,
cord-015021-pol2qm74	4484	44	in	in	IN
cord-015021-pol2qm74	4484	45	group	group	NN
cord-015021-pol2qm74	4484	46	V	v	NN
cord-015021-pol2qm74	4484	47	37.4_+4.9x10(6	37.4_+4.9x10(6	CD
cord-015021-pol2qm74	4484	48	)	)	-RRB-
cord-015021-pol2qm74	4484	49	.	.	.
cord-015021-pol2qm74	4485	1	The	the	DT
cord-015021-pol2qm74	4485	2	evident	evident	JJ
cord-015021-pol2qm74	4485	3	increase	increase	NN
cord-015021-pol2qm74	4485	4	in	in	IN
cord-015021-pol2qm74	4485	5	BMC	BMC	NNP
cord-015021-pol2qm74	4485	6	yield	yield	NN
cord-015021-pol2qm74	4485	7	in	in	IN
cord-015021-pol2qm74	4485	8	all	all	DT
cord-015021-pol2qm74	4485	9	groups	group	NNS
cord-015021-pol2qm74	4485	10	continued	continue	VBD
cord-015021-pol2qm74	4485	11	until	until	IN
cord-015021-pol2qm74	4485	12	day	day	NN
cord-015021-pol2qm74	4485	13	30	30	CD
cord-015021-pol2qm74	4485	14	.	.	.
cord-015021-pol2qm74	4486	1	Increase	increase	VB
cord-015021-pol2qm74	4486	2	in	in	IN
cord-015021-pol2qm74	4486	3	weight	weight	NN
cord-015021-pol2qm74	4486	4	and	and	CC
cord-015021-pol2qm74	4486	5	total	total	JJ
cord-015021-pol2qm74	4486	6	cell	cell	NN
cord-015021-pol2qm74	4486	7	count	count	NN
cord-015021-pol2qm74	4486	8	of	of	IN
cord-015021-pol2qm74	4486	9	spleen	spleen	NNS
cord-015021-pol2qm74	4486	10	and	and	CC
cord-015021-pol2qm74	4486	11	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	4486	12	lymph	lymph	NN
cord-015021-pol2qm74	4486	13	nodes	node	NNS
cord-015021-pol2qm74	4486	14	in	in	IN
cord-015021-pol2qm74	4486	15	all	all	DT
cord-015021-pol2qm74	4486	16	but	but	CC
cord-015021-pol2qm74	4486	17	group	group	NN
cord-015021-pol2qm74	4486	18	III	III	NNP
cord-015021-pol2qm74	4486	19	was	be	VBD
cord-015021-pol2qm74	4486	20	also	also	RB
cord-015021-pol2qm74	4486	21	found	find	VBN
cord-015021-pol2qm74	4486	22	.	.	.
cord-015021-pol2qm74	4487	1	No	no	DT
cord-015021-pol2qm74	4487	2	differences	difference	NNS
cord-015021-pol2qm74	4487	3	in	in	IN
cord-015021-pol2qm74	4487	4	percentage	percentage	NN
cord-015021-pol2qm74	4487	5	of	of	IN
cord-015021-pol2qm74	4487	6	maturing	mature	VBG
cord-015021-pol2qm74	4487	7	erythroid	erythroid	NN
cord-015021-pol2qm74	4487	8	cells	cell	NNS
cord-015021-pol2qm74	4487	9	,	,	,
cord-015021-pol2qm74	4487	10	but	but	CC
cord-015021-pol2qm74	4487	11	higher	high	JJR
cord-015021-pol2qm74	4487	12	of	of	IN
cord-015021-pol2qm74	4487	13	mature	mature	JJ
cord-015021-pol2qm74	4487	14	myeloid	myeloid	NN
cord-015021-pol2qm74	4487	15	cells	cell	NNS
cord-015021-pol2qm74	4487	16	and	and	CC
cord-015021-pol2qm74	4487	17	lower	low	JJR
cord-015021-pol2qm74	4487	18	of	of	IN
cord-015021-pol2qm74	4487	19	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4487	20	were	be	VBD
cord-015021-pol2qm74	4487	21	observed	observe	VBN
cord-015021-pol2qm74	4487	22	.	.	.
cord-015021-pol2qm74	4488	1	CONCLUSIONS	conclusion	NNS
cord-015021-pol2qm74	4488	2	.	.	.
cord-015021-pol2qm74	4489	1	Trauma	trauma	NN
cord-015021-pol2qm74	4489	2	of	of	IN
cord-015021-pol2qm74	4489	3	skin	skin	NN
cord-015021-pol2qm74	4489	4	,	,	,
cord-015021-pol2qm74	4489	5	muscles	muscle	NNS
cord-015021-pol2qm74	4489	6	,	,	,
cord-015021-pol2qm74	4489	7	and	and	CC
cord-015021-pol2qm74	4489	8	bone	bone	NN
cord-015021-pol2qm74	4489	9	brought	bring	VBD
cord-015021-pol2qm74	4489	10	about	about	RP
cord-015021-pol2qm74	4489	11	an	an	DT
cord-015021-pol2qm74	4489	12	increase	increase	NN
cord-015021-pol2qm74	4489	13	in	in	IN
cord-015021-pol2qm74	4489	14	bone	bone	NN
cord-015021-pol2qm74	4489	15	marrow	marrow	NN
cord-015021-pol2qm74	4489	16	cellularity	cellularity	NN
cord-015021-pol2qm74	4489	17	and	and	CC
cord-015021-pol2qm74	4489	18	acceleration	acceleration	NN
cord-015021-pol2qm74	4489	19	of	of	IN
cord-015021-pol2qm74	4489	20	maturation	maturation	NN
cord-015021-pol2qm74	4489	21	of	of	IN
cord-015021-pol2qm74	4489	22	myeloid	myeloid	NN
cord-015021-pol2qm74	4489	23	lineage	lineage	NN
cord-015021-pol2qm74	4489	24	.	.	.
cord-015021-pol2qm74	4490	1	Transplantation	transplantation	NN
cord-015021-pol2qm74	4490	2	of	of	IN
cord-015021-pol2qm74	4490	3	BM	BM	NNP
cord-015021-pol2qm74	4490	4	ceils	ceil	NNS
cord-015021-pol2qm74	4490	5	alone	alone	RB
cord-015021-pol2qm74	4490	6	did	do	VBD
cord-015021-pol2qm74	4490	7	not	not	RB
cord-015021-pol2qm74	4490	8	produce	produce	VB
cord-015021-pol2qm74	4490	9	this	this	DT
cord-015021-pol2qm74	4490	10	effect	effect	NN
cord-015021-pol2qm74	4490	11	.	.	.
cord-015021-pol2qm74	4491	1	Transplantation	transplantation	NN
cord-015021-pol2qm74	4491	2	of	of	IN
cord-015021-pol2qm74	4491	3	BM	BM	NNP
cord-015021-pol2qm74	4491	4	in	in	IN
cord-015021-pol2qm74	4491	5	limb	limb	NN
cord-015021-pol2qm74	4491	6	graft	graft	NN
cord-015021-pol2qm74	4491	7	is	be	VBZ
cord-015021-pol2qm74	4491	8	a	a	DT
cord-015021-pol2qm74	4491	9	good	good	JJ
cord-015021-pol2qm74	4491	10	model	model	NN
cord-015021-pol2qm74	4491	11	for	for	IN
cord-015021-pol2qm74	4491	12	studies	study	NNS
cord-015021-pol2qm74	4491	13	of	of	IN
cord-015021-pol2qm74	4491	14	natural	natural	JJ
cord-015021-pol2qm74	4491	15	factors	factor	NNS
cord-015021-pol2qm74	4491	16	reaulatin~	reaulatin~	VBP
cord-015021-pol2qm74	4491	17	BM	BM	NNP
cord-015021-pol2qm74	4491	18	hemormesis	hemormesis	NN
cord-015021-pol2qm74	4491	19	.	.	.
cord-015021-pol2qm74	4492	1	This	this	DT
cord-015021-pol2qm74	4492	2	study	study	NN
cord-015021-pol2qm74	4492	3	sought	seek	VBD
cord-015021-pol2qm74	4492	4	to	to	TO
cord-015021-pol2qm74	4492	5	determine	determine	VB
cord-015021-pol2qm74	4492	6	a	a	DT
cord-015021-pol2qm74	4492	7	relationship	relationship	NN
cord-015021-pol2qm74	4492	8	,	,	,
cord-015021-pol2qm74	4492	9	if	if	IN
cord-015021-pol2qm74	4492	10	any	any	DT
cord-015021-pol2qm74	4492	11	,	,	,
cord-015021-pol2qm74	4492	12	between	between	IN
cord-015021-pol2qm74	4492	13	the	the	DT
cord-015021-pol2qm74	4492	14	degree	degree	NN
cord-015021-pol2qm74	4492	15	of	of	IN
cord-015021-pol2qm74	4492	16	hypochclesterolemia	hypochclesterolemia	NNP
cord-015021-pol2qm74	4492	17	upon	upon	IN
cord-015021-pol2qm74	4492	18	trauma	trauma	NN
cord-015021-pol2qm74	4492	19	patients	patient	NNS
cord-015021-pol2qm74	4492	20	'	'	POS
cord-015021-pol2qm74	4492	21	admission	admission	NN
cord-015021-pol2qm74	4492	22	and	and	CC
cord-015021-pol2qm74	4492	23	their	-PRON-	PRP$
cord-015021-pol2qm74	4492	24	subsequent	subsequent	JJ
cord-015021-pol2qm74	4492	25	outcome	outcome	NN
cord-015021-pol2qm74	4492	26	.	.	.
cord-015021-pol2qm74	4493	1	All	all	DT
cord-015021-pol2qm74	4493	2	blunt	blunt	JJ
cord-015021-pol2qm74	4493	3	and	and	CC
cord-015021-pol2qm74	4493	4	penetrating	penetrating	JJ
cord-015021-pol2qm74	4493	5	trauma	trauma	NN
cord-015021-pol2qm74	4493	6	patients	patient	NNS
cord-015021-pol2qm74	4493	7	admitted	admit	VBD
cord-015021-pol2qm74	4493	8	to	to	IN
cord-015021-pol2qm74	4493	9	a	a	DT
cord-015021-pol2qm74	4493	10	Level	level	NN
cord-015021-pol2qm74	4493	11	I	-PRON-	PRP
cord-015021-pol2qm74	4493	12	facility	facility	NN
cord-015021-pol2qm74	4493	13	from	from	IN
cord-015021-pol2qm74	4493	14	1987	1987	CD
cord-015021-pol2qm74	4493	15	through	through	IN
cord-015021-pol2qm74	4493	16	1991	1991	CD
cord-015021-pol2qm74	4493	17	,	,	,
cord-015021-pol2qm74	4493	18	and	and	CC
cord-015021-pol2qm74	4493	19	who	who	WP
cord-015021-pol2qm74	4493	20	had	have	VBD
cord-015021-pol2qm74	4493	21	serum	serum	NN
cord-015021-pol2qm74	4493	22	cholesterol	cholesterol	NN
cord-015021-pol2qm74	4493	23	assayed	assay	VBN
cord-015021-pol2qm74	4493	24	during	during	IN
cord-015021-pol2qm74	4493	25	the	the	DT
cord-015021-pol2qm74	4493	26	first	first	JJ
cord-015021-pol2qm74	4493	27	24	24	CD
cord-015021-pol2qm74	4493	28	hrs	hrs	NN
cord-015021-pol2qm74	4493	29	were	be	VBD
cord-015021-pol2qm74	4493	30	retrospectively	retrospectively	RB
cord-015021-pol2qm74	4493	31	studied	study	VBN
cord-015021-pol2qm74	4493	32	for	for	IN
cord-015021-pol2qm74	4493	33	development	development	NN
cord-015021-pol2qm74	4493	34	of	of	IN
cord-015021-pol2qm74	4493	35	death	death	NN
cord-015021-pol2qm74	4493	36	or	or	CC
cord-015021-pol2qm74	4493	37	significant	significant	JJ
cord-015021-pol2qm74	4493	38	organ	organ	NN
cord-015021-pol2qm74	4493	39	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4493	40	.	.	.
cord-015021-pol2qm74	4494	1	The	the	DT
cord-015021-pol2qm74	4494	2	Mantel	Mantel	NNP
cord-015021-pol2qm74	4494	3	-	-	HYPH
cord-015021-pol2qm74	4494	4	Kaenzel	Kaenzel	NNP
cord-015021-pol2qm74	4494	5	chisquared	chisquare	VBD
cord-015021-pol2qm74	4494	6	test	test	NN
cord-015021-pol2qm74	4494	7	was	be	VBD
cord-015021-pol2qm74	4494	8	used	use	VBN
cord-015021-pol2qm74	4494	9	to	to	TO
cord-015021-pol2qm74	4494	10	determine	determine	VB
cord-015021-pol2qm74	4494	11	significance	significance	NN
cord-015021-pol2qm74	4494	12	of	of	IN
cord-015021-pol2qm74	4494	13	data	datum	NNS
cord-015021-pol2qm74	4494	14	at	at	IN
cord-015021-pol2qm74	4494	15	the	the	DT
cord-015021-pol2qm74	4494	16	p	p	NN
cord-015021-pol2qm74	4494	17	<	<	XX
cord-015021-pol2qm74	4494	18	0.05	0.05	CD
cord-015021-pol2qm74	4494	19	level	level	NN
cord-015021-pol2qm74	4494	20	.	.	.
cord-015021-pol2qm74	4495	1	RESULTS	result	NNS
cord-015021-pol2qm74	4495	2	:	:	:
cord-015021-pol2qm74	4496	1	2909	2909	CD
cord-015021-pol2qm74	4496	2	trauma	trauma	NN
cord-015021-pol2qm74	4496	3	patients	patient	NNS
cord-015021-pol2qm74	4496	4	were	be	VBD
cord-015021-pol2qm74	4496	5	admitted	admit	VBN
cord-015021-pol2qm74	4496	6	during	during	IN
cord-015021-pol2qm74	4496	7	the	the	DT
cord-015021-pol2qm74	4496	8	four	four	CD
cord-015021-pol2qm74	4496	9	-	-	HYPH
cord-015021-pol2qm74	4496	10	year	year	NN
cord-015021-pol2qm74	4496	11	period	period	NN
cord-015021-pol2qm74	4496	12	who	who	WP
cord-015021-pol2qm74	4496	13	had	have	VBD
cord-015021-pol2qm74	4496	14	serum	serum	NN
cord-015021-pol2qm74	4496	15	cholesterol	cholesterol	NN
cord-015021-pol2qm74	4496	16	assays	assay	NNS
cord-015021-pol2qm74	4496	17	performed	perform	VBN
cord-015021-pol2qm74	4496	18	in	in	IN
cord-015021-pol2qm74	4496	19	the	the	DT
cord-015021-pol2qm74	4496	20	first	first	JJ
cord-015021-pol2qm74	4496	21	24	24	CD
cord-015021-pol2qm74	4496	22	hrs	hrs	NN
cord-015021-pol2qm74	4496	23	.	.	.
cord-015021-pol2qm74	4497	1	24	24	CD
cord-015021-pol2qm74	4497	2	patients	patient	NNS
cord-015021-pol2qm74	4497	3	had	have	VBD
cord-015021-pol2qm74	4497	4	cholesterol	cholesterol	NN
cord-015021-pol2qm74	4497	5	levels	level	NNS
cord-015021-pol2qm74	4497	6	less	less	JJR
cord-015021-pol2qm74	4497	7	than	than	IN
cord-015021-pol2qm74	4497	8	50	50	CD
cord-015021-pol2qm74	4497	9	mg	mg	NNP
cord-015021-pol2qm74	4497	10	/	/	SYM
cord-015021-pol2qm74	4497	11	dl	dl	NN
cord-015021-pol2qm74	4497	12	;	;	:
cord-015021-pol2qm74	4497	13	8	8	CD
cord-015021-pol2qm74	4497	14	of	of	IN
cord-015021-pol2qm74	4497	15	these	these	DT
cord-015021-pol2qm74	4497	16	(	(	-LRB-
cord-015021-pol2qm74	4497	17	33.3	33.3	CD
cord-015021-pol2qm74	4497	18	%	%	NN
cord-015021-pol2qm74	4497	19	)	)	-RRB-
cord-015021-pol2qm74	4497	20	died	die	VBD
cord-015021-pol2qm74	4497	21	,	,	,
cord-015021-pol2qm74	4497	22	3	3	CD
cord-015021-pol2qm74	4497	23	(	(	-LRB-
cord-015021-pol2qm74	4497	24	12.5	12.5	CD
cord-015021-pol2qm74	4497	25	%	%	NN
cord-015021-pol2qm74	4497	26	)	)	-RRB-
cord-015021-pol2qm74	4497	27	developed	develop	VBD
cord-015021-pol2qm74	4497	28	ARDS	ARDS	NNP
cord-015021-pol2qm74	4497	29	,	,	,
cord-015021-pol2qm74	4497	30	5	5	CD
cord-015021-pol2qm74	4497	31	(	(	-LRB-
cord-015021-pol2qm74	4497	32	20.8	20.8	CD
cord-015021-pol2qm74	4497	33	%	%	NN
cord-015021-pol2qm74	4497	34	)	)	-RRB-
cord-015021-pol2qm74	4497	35	developed	develop	VBN
cord-015021-pol2qm74	4497	36	acute	acute	JJ
cord-015021-pol2qm74	4497	37	renal	renal	JJ
cord-015021-pol2qm74	4497	38	failure	failure	NN
cord-015021-pol2qm74	4497	39	,	,	,
cord-015021-pol2qm74	4497	40	and	and	CC
cord-015021-pol2qm74	4497	41	8	8	CD
cord-015021-pol2qm74	4497	42	(	(	-LRB-
cord-015021-pol2qm74	4497	43	33.3	33.3	CD
cord-015021-pol2qm74	4497	44	%	%	NN
cord-015021-pol2qm74	4497	45	)	)	-RRB-
cord-015021-pol2qm74	4497	46	developed	develop	VBN
cord-015021-pol2qm74	4497	47	multisystem	multisystem	JJ
cord-015021-pol2qm74	4497	48	organ	organ	NN
cord-015021-pol2qm74	4497	49	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4497	50	;	;	:
cord-015021-pol2qm74	4497	51	hypocholesterolemia	hypocholesterolemia	NN
cord-015021-pol2qm74	4497	52	in	in	IN
cord-015021-pol2qm74	4497	53	these	these	DT
cord-015021-pol2qm74	4497	54	patients	patient	NNS
cord-015021-pol2qm74	4497	55	was	be	VBD
cord-015021-pol2qm74	4497	56	not	not	RB
cord-015021-pol2qm74	4497	57	due	due	JJ
cord-015021-pol2qm74	4497	58	to	to	IN
cord-015021-pol2qm74	4497	59	liver	liver	NN
cord-015021-pol2qm74	4497	60	injury	injury	NN
cord-015021-pol2qm74	4497	61	or	or	CC
cord-015021-pol2qm74	4497	62	massive	massive	JJ
cord-015021-pol2qm74	4497	63	fluid	fluid	JJ
cord-015021-pol2qm74	4497	64	administration	administration	NN
cord-015021-pol2qm74	4497	65	.	.	.
cord-015021-pol2qm74	4498	1	The	the	DT
cord-015021-pol2qm74	4498	2	risk	risk	NN
cord-015021-pol2qm74	4498	3	of	of	IN
cord-015021-pol2qm74	4498	4	death	death	NN
cord-015021-pol2qm74	4498	5	was	be	VBD
cord-015021-pol2qm74	4498	6	5	5	CD
cord-015021-pol2qm74	4498	7	times	time	NNS
cord-015021-pol2qm74	4498	8	greater	great	JJR
cord-015021-pol2qm74	4498	9	and	and	CC
cord-015021-pol2qm74	4498	10	risk	risk	NN
cord-015021-pol2qm74	4498	11	of	of	IN
cord-015021-pol2qm74	4498	12	multi	multi	JJ
cord-015021-pol2qm74	4498	13	-	-	JJ
cord-015021-pol2qm74	4498	14	organ	organ	JJ
cord-015021-pol2qm74	4498	15	failure	failure	NN
cord-015021-pol2qm74	4498	16	3	3	CD
cord-015021-pol2qm74	4498	17	times	time	NNS
cord-015021-pol2qm74	4498	18	greater	great	JJR
cord-015021-pol2qm74	4498	19	in	in	IN
cord-015021-pol2qm74	4498	20	this	this	DT
cord-015021-pol2qm74	4498	21	group	group	NN
cord-015021-pol2qm74	4498	22	than	than	IN
cord-015021-pol2qm74	4498	23	in	in	IN
cord-015021-pol2qm74	4498	24	those	those	DT
cord-015021-pol2qm74	4498	25	with	with	IN
cord-015021-pol2qm74	4498	26	a	a	DT
cord-015021-pol2qm74	4498	27	normal	normal	JJ
cord-015021-pol2qm74	4498	28	serum	serum	NN
cord-015021-pol2qm74	4498	29	cholesterol	cholesterol	NN
cord-015021-pol2qm74	4498	30	(	(	-LRB-
cord-015021-pol2qm74	4498	31	>	>	XX
cord-015021-pol2qm74	4499	1	if0	if0	NNP
cord-015021-pol2qm74	4499	2	mg	mg	NNP
cord-015021-pol2qm74	4499	3	/	/	SYM
cord-015021-pol2qm74	4499	4	dl	dl	NN
cord-015021-pol2qm74	4499	5	;	;	:
cord-015021-pol2qm74	4500	1	1820	1820	CD
cord-015021-pol2qm74	4500	2	patients	patient	NNS
cord-015021-pol2qm74	4500	3	;	;	:
cord-015021-pol2qm74	4500	4	p<0.05	p<0.05	CD
cord-015021-pol2qm74	4500	5	)	)	-RRB-
cord-015021-pol2qm74	4500	6	.	.	.
cord-015021-pol2qm74	4501	1	CONCLUSIONS	conclusion	NNS
cord-015021-pol2qm74	4501	2	:	:	:
cord-015021-pol2qm74	4502	1	Admission	admission	NN
cord-015021-pol2qm74	4502	2	serum	serum	NN
cord-015021-pol2qm74	4502	3	cholesterol	cholesterol	NN
cord-015021-pol2qm74	4502	4	level	level	NN
cord-015021-pol2qm74	4502	5	in	in	IN
cord-015021-pol2qm74	4502	6	the	the	DT
cord-015021-pol2qm74	4502	7	trauma	trauma	NN
cord-015021-pol2qm74	4502	8	patient	patient	NN
cord-015021-pol2qm74	4502	9	serves	serve	VBZ
cord-015021-pol2qm74	4502	10	as	as	IN
cord-015021-pol2qm74	4502	11	a	a	DT
cord-015021-pol2qm74	4502	12	powerful	powerful	JJ
cord-015021-pol2qm74	4502	13	marker	marker	NN
cord-015021-pol2qm74	4502	14	for	for	IN
cord-015021-pol2qm74	4502	15	those	those	DT
cord-015021-pol2qm74	4502	16	at	at	IN
cord-015021-pol2qm74	4502	17	risk	risk	NN
cord-015021-pol2qm74	4502	18	of	of	IN
cord-015021-pol2qm74	4502	19	subsequent	subsequent	JJ
cord-015021-pol2qm74	4502	20	organ	organ	NN
cord-015021-pol2qm74	4502	21	failure	failure	NN
cord-015021-pol2qm74	4502	22	or	or	CC
cord-015021-pol2qm74	4502	23	death	death	NN
cord-015021-pol2qm74	4502	24	.	.	.
cord-015021-pol2qm74	4503	1	Hypocholesterolemia	Hypocholesterolemia	NNP
cord-015021-pol2qm74	4503	2	in	in	IN
cord-015021-pol2qm74	4503	3	this	this	DT
cord-015021-pol2qm74	4503	4	setting	setting	NN
cord-015021-pol2qm74	4503	5	may	may	MD
cord-015021-pol2qm74	4503	6	result	result	VB
cord-015021-pol2qm74	4503	7	from	from	IN
cord-015021-pol2qm74	4503	8	organ	organ	NN
cord-015021-pol2qm74	4503	9	hypoperfusion	hypoperfusion	NN
cord-015021-pol2qm74	4503	10	and	and	CC
cord-015021-pol2qm74	4503	11	humeral	humeral	JJ
cord-015021-pol2qm74	4503	12	mediator	mediator	NN
cord-015021-pol2qm74	4503	13	release	release	NN
cord-015021-pol2qm74	4503	14	.	.	.
cord-015021-pol2qm74	4504	1	Lung	lung	NN
cord-015021-pol2qm74	4504	2	tissue	tissue	NN
cord-015021-pol2qm74	4504	3	contains	contain	VBZ
cord-015021-pol2qm74	4504	4	many	many	JJ
cord-015021-pol2qm74	4504	5	immunocompetent	immunocompetent	JJ
cord-015021-pol2qm74	4504	6	cells	cell	NNS
cord-015021-pol2qm74	4504	7	.	.	.
cord-015021-pol2qm74	4505	1	Resection	resection	NN
cord-015021-pol2qm74	4505	2	,	,	,
cord-015021-pol2qm74	4505	3	therefore	therefore	RB
cord-015021-pol2qm74	4505	4	,	,	,
cord-015021-pol2qm74	4505	5	is	be	VBZ
cord-015021-pol2qm74	4505	6	expected	expect	VBN
cord-015021-pol2qm74	4505	7	to	to	TO
cord-015021-pol2qm74	4505	8	activate	activate	VB
cord-015021-pol2qm74	4505	9	extensively	extensively	RB
cord-015021-pol2qm74	4505	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4505	11	mediators	mediator	NNS
cord-015021-pol2qm74	4505	12	such	such	JJ
cord-015021-pol2qm74	4505	13	as	as	IN
cord-015021-pol2qm74	4505	14	PMN	pmn	NN
cord-015021-pol2qm74	4505	15	-	-	HYPH
cord-015021-pol2qm74	4505	16	elastase	elastase	NN
cord-015021-pol2qm74	4505	17	,	,	,
cord-015021-pol2qm74	4505	18	pmstanoids	pmstanoid	NNS
cord-015021-pol2qm74	4505	19	and	and	CC
cord-015021-pol2qm74	4505	20	pteridines	pteridine	NNS
cord-015021-pol2qm74	4505	21	.	.	.
cord-015021-pol2qm74	4506	1	In	in	IN
cord-015021-pol2qm74	4506	2	a	a	DT
cord-015021-pol2qm74	4506	3	prospective	prospective	JJ
cord-015021-pol2qm74	4506	4	clinical	clinical	JJ
cord-015021-pol2qm74	4506	5	study	study	NN
cord-015021-pol2qm74	4506	6	we	-PRON-	PRP
cord-015021-pol2qm74	4506	7	compared	compare	VBD
cord-015021-pol2qm74	4506	8	35	35	CD
cord-015021-pol2qm74	4506	9	patients	patient	NNS
cord-015021-pol2qm74	4506	10	(	(	-LRB-
cord-015021-pol2qm74	4506	11	pts	pts	NN
cord-015021-pol2qm74	4506	12	)	)	-RRB-
cord-015021-pol2qm74	4506	13	undergoing	undergo	VBG
cord-015021-pol2qm74	4506	14	either	either	CC
cord-015021-pol2qm74	4506	15	thomcotomy	thomcotomy	NN
cord-015021-pol2qm74	4506	16	with	with	IN
cord-015021-pol2qm74	4506	17	or	or	CC
cord-015021-pol2qm74	4506	18	without	without	IN
cord-015021-pol2qm74	4506	19	lung	lung	NN
cord-015021-pol2qm74	4506	20	tissue	tissue	NN
cord-015021-pol2qm74	4506	21	msectioh	msectioh	NNP
cord-015021-pol2qm74	4506	22	and	and	CC
cord-015021-pol2qm74	4506	23	tboracoscopic	tboracoscopic	NNP
cord-015021-pol2qm74	4506	24	lung	lung	NN
cord-015021-pol2qm74	4506	25	resection	resection	NN
cord-015021-pol2qm74	4506	26	concerning	concern	VBG
cord-015021-pol2qm74	4506	27	activation	activation	NN
cord-015021-pol2qm74	4506	28	of	of	IN
cord-015021-pol2qm74	4506	29	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4506	30	response	response	NN
cord-015021-pol2qm74	4506	31	.	.	.
cord-015021-pol2qm74	4507	1	Material	Material	NNP
cord-015021-pol2qm74	4507	2	&	&	CC
cord-015021-pol2qm74	4507	3	Methods	Methods	NNPS
cord-015021-pol2qm74	4507	4	:	:	:
cord-015021-pol2qm74	4507	5	Group	Group	NNP
cord-015021-pol2qm74	4507	6	A	A	NNP
cord-015021-pol2qm74	4507	7	pts	pts	NN
cord-015021-pol2qm74	4507	8	(	(	-LRB-
cord-015021-pol2qm74	4507	9	n=8	n=8	NN
cord-015021-pol2qm74	4507	10	)	)	-RRB-
cord-015021-pol2qm74	4507	11	had	have	VBD
cord-015021-pol2qm74	4507	12	thoraantomy	thoraantomy	NN
cord-015021-pol2qm74	4507	13	but	but	CC
cord-015021-pol2qm74	4507	14	no	no	DT
cord-015021-pol2qm74	4507	15	lung	lung	NN
cord-015021-pol2qm74	4507	16	tissue	tissue	NN
cord-015021-pol2qm74	4507	17	injury	injury	NN
cord-015021-pol2qm74	4507	18	;	;	:
cord-015021-pol2qm74	4507	19	group	group	NN
cord-015021-pol2qm74	4507	20	B	b	NN
cord-015021-pol2qm74	4507	21	pts	pts	NNP
cord-015021-pol2qm74	4507	22	(	(	-LRB-
cord-015021-pol2qm74	4507	23	n	n	NN
cord-015021-pol2qm74	4507	24	=	=	NN
cord-015021-pol2qm74	4507	25	lS	ls	NN
cord-015021-pol2qm74	4507	26	)	)	-RRB-
cord-015021-pol2qm74	4507	27	had	have	VBD
cord-015021-pol2qm74	4507	28	thoracotomy	thoracotomy	NN
cord-015021-pol2qm74	4507	29	and	and	CC
cord-015021-pol2qm74	4507	30	lung	lung	NN
cord-015021-pol2qm74	4507	31	tissue	tissue	NN
cord-015021-pol2qm74	4507	32	resection	resection	NN
cord-015021-pol2qm74	4507	33	due	due	IN
cord-015021-pol2qm74	4507	34	to	to	IN
cord-015021-pol2qm74	4507	35	benign	benign	JJ
cord-015021-pol2qm74	4507	36	diseases	disease	NNS
cord-015021-pol2qm74	4507	37	;	;	:
cord-015021-pol2qm74	4507	38	group	group	NN
cord-015021-pol2qm74	4507	39	C	C	NNP
cord-015021-pol2qm74	4507	40	(	(	-LRB-
cord-015021-pol2qm74	4507	41	n=9	n=9	NN
cord-015021-pol2qm74	4507	42	)	)	-RRB-
cord-015021-pol2qm74	4507	43	represents	represent	VBZ
cord-015021-pol2qm74	4507	44	group	group	NN
cord-015021-pol2qm74	4507	45	B	B	NNP
cord-015021-pol2qm74	4507	46	tissue	tissue	NN
cord-015021-pol2qm74	4507	47	resection	resection	NN
cord-015021-pol2qm74	4507	48	but	but	CC
cord-015021-pol2qm74	4507	49	using	use	VBG
cord-015021-pol2qm74	4507	50	a	a	DT
cord-015021-pol2qm74	4507	51	thomcoscopic	thomcoscopic	JJ
cord-015021-pol2qm74	4507	52	procedure	procedure	NN
cord-015021-pol2qm74	4507	53	.	.	.
cord-015021-pol2qm74	4508	1	The	the	DT
cord-015021-pol2qm74	4508	2	following	following	JJ
cord-015021-pol2qm74	4508	3	parameters	parameter	NNS
cord-015021-pol2qm74	4508	4	were	be	VBD
cord-015021-pol2qm74	4508	5	determined	determine	VBN
cord-015021-pol2qm74	4508	6	pre-	pre-	JJ
cord-015021-pol2qm74	4508	7	,	,	,
cord-015021-pol2qm74	4508	8	peri-	peri-	JJ
cord-015021-pol2qm74	4508	9	,	,	,
cord-015021-pol2qm74	4508	10	and	and	CC
cord-015021-pol2qm74	4508	11	postoperatively	postoperatively	RB
cord-015021-pol2qm74	4508	12	:	:	:
cord-015021-pol2qm74	4509	1	Elastase	Elastase	NNP
cord-015021-pol2qm74	4509	2	and	and	CC
cord-015021-pol2qm74	4509	3	CRP	CRP	NNP
cord-015021-pol2qm74	4509	4	as	as	IN
cord-015021-pol2qm74	4509	5	indicators	indicator	NNS
cord-015021-pol2qm74	4509	6	of	of	IN
cord-015021-pol2qm74	4509	7	activation	activation	NN
cord-015021-pol2qm74	4509	8	of	of	IN
cord-015021-pol2qm74	4509	9	PMN	pmn	NN
cord-015021-pol2qm74	4509	10	-	-	HYPH
cord-015021-pol2qm74	4509	11	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	4509	12	and	and	CC
cord-015021-pol2qm74	4509	13	injury	injury	NN
cord-015021-pol2qm74	4509	14	severity	severity	NN
cord-015021-pol2qm74	4509	15	;	;	:
cord-015021-pol2qm74	4509	16	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	4509	17	(	(	-LRB-
cord-015021-pol2qm74	4509	18	PGI	PGI	NNP
cord-015021-pol2qm74	4509	19	2	2	CD
cord-015021-pol2qm74	4509	20	)	)	-RRB-
cord-015021-pol2qm74	4509	21	and	and	CC
cord-015021-pol2qm74	4509	22	thromboxane	thromboxane	NN
cord-015021-pol2qm74	4509	23	(	(	-LRB-
cord-015021-pol2qm74	4509	24	TXA~	TXA~	NNP
cord-015021-pol2qm74	4509	25	)	)	-RRB-
cord-015021-pol2qm74	4509	26	as	as	IN
cord-015021-pol2qm74	4509	27	parameters	parameter	NNS
cord-015021-pol2qm74	4509	28	of	of	IN
cord-015021-pol2qm74	4509	29	lung	lung	NN
cord-015021-pol2qm74	4509	30	endothelial	endothelial	JJ
cord-015021-pol2qm74	4509	31	response	response	NN
cord-015021-pol2qm74	4509	32	;	;	:
cord-015021-pol2qm74	4509	33	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	4509	34	F2~	F2~	NNP
cord-015021-pol2qm74	4509	35	(	(	-LRB-
cord-015021-pol2qm74	4509	36	PGF~	pgf~	NN
cord-015021-pol2qm74	4509	37	)	)	-RRB-
cord-015021-pol2qm74	4509	38	and	and	CC
cord-015021-pol2qm74	4509	39	PGM	PGM	NNP
cord-015021-pol2qm74	4509	40	representing	represent	VBG
cord-015021-pol2qm74	4509	41	pulmonaly	pulmonaly	NNP
cord-015021-pol2qm74	4509	42	metabolic	metabolic	JJ
cord-015021-pol2qm74	4509	43	activity	activity	NN
cord-015021-pol2qm74	4509	44	;	;	:
cord-015021-pol2qm74	4509	45	PGE	PGE	NNP
cord-015021-pol2qm74	4509	46	a	a	NNP
cord-015021-pol2qm74	4509	47	and	and	CC
cord-015021-pol2qm74	4509	48	neopterin	neopterin	NN
cord-015021-pol2qm74	4509	49	as	as	IN
cord-015021-pol2qm74	4509	50	proof	proof	NN
cord-015021-pol2qm74	4509	51	of	of	IN
cord-015021-pol2qm74	4509	52	macmphage	macmphage	NNP
cord-015021-pol2qm74	4509	53	activation	activation	NN
cord-015021-pol2qm74	4509	54	.	.	.
cord-015021-pol2qm74	4510	1	Statistics	statistic	NNS
cord-015021-pol2qm74	4510	2	were	be	VBD
cord-015021-pol2qm74	4510	3	performed	perform	VBN
cord-015021-pol2qm74	4510	4	using	use	VBG
cord-015021-pol2qm74	4510	5	analysis	analysis	NN
cord-015021-pol2qm74	4510	6	of	of	IN
cord-015021-pol2qm74	4510	7	variance	variance	NN
cord-015021-pol2qm74	4510	8	for	for	IN
cord-015021-pol2qm74	4510	9	repeated	repeat	VBN
cord-015021-pol2qm74	4510	10	measures	measure	NNS
cord-015021-pol2qm74	4510	11	.	.	.
cord-015021-pol2qm74	4511	1	Results	result	NNS
cord-015021-pol2qm74	4511	2	:	:	:
cord-015021-pol2qm74	4512	1	Group	Group	NNP
cord-015021-pol2qm74	4512	2	B	B	NNP
cord-015021-pol2qm74	4512	3	pts	pts	NNP
cord-015021-pol2qm74	4512	4	revealed	reveal	VBD
cord-015021-pol2qm74	4512	5	postoperatively	postoperatively	RB
cord-015021-pol2qm74	4512	6	an	an	DT
cord-015021-pol2qm74	4512	7	increase	increase	NN
cord-015021-pol2qm74	4512	8	in	in	IN
cord-015021-pol2qm74	4512	9	CRP	CRP	NNP
cord-015021-pol2qm74	4512	10	(	(	-LRB-
cord-015021-pol2qm74	4512	11	p<0.001	p<0.001	CD
cord-015021-pol2qm74	4512	12	)	)	-RRB-
cord-015021-pol2qm74	4512	13	indicating	indicate	VBG
cord-015021-pol2qm74	4512	14	a	a	DT
cord-015021-pol2qm74	4512	15	higher	high	JJR
cord-015021-pol2qm74	4512	16	injury	injury	NN
cord-015021-pol2qm74	4512	17	severity	severity	NN
cord-015021-pol2qm74	4512	18	in	in	IN
cord-015021-pol2qm74	4512	19	comparison	comparison	NN
cord-015021-pol2qm74	4512	20	to	to	IN
cord-015021-pol2qm74	4512	21	the	the	DT
cord-015021-pol2qm74	4512	22	thoracoscopic	thoracoscopic	NNP
cord-015021-pol2qm74	4512	23	procedure	procedure	NN
cord-015021-pol2qm74	4512	24	(	(	-LRB-
cord-015021-pol2qm74	4512	25	C	C	NNP
cord-015021-pol2qm74	4512	26	)	)	-RRB-
cord-015021-pol2qm74	4512	27	.	.	.
cord-015021-pol2qm74	4513	1	Both	both	DT
cord-015021-pol2qm74	4513	2	,	,	,
cord-015021-pol2qm74	4513	3	controls	control	VBZ
cord-015021-pol2qm74	4513	4	(	(	-LRB-
cord-015021-pol2qm74	4513	5	A	a	NN
cord-015021-pol2qm74	4513	6	)	)	-RRB-
cord-015021-pol2qm74	4513	7	and	and	CC
cord-015021-pol2qm74	4513	8	group	group	NN
cord-015021-pol2qm74	4513	9	C	C	NNP
cord-015021-pol2qm74	4513	10	pts	pts	NNP
cord-015021-pol2qm74	4513	11	did	do	VBD
cord-015021-pol2qm74	4513	12	not	not	RB
cord-015021-pol2qm74	4513	13	show	show	VB
cord-015021-pol2qm74	4513	14	PMN	PMN	NNP
cord-015021-pol2qm74	4513	15	-	-	HYPH
cord-015021-pol2qm74	4513	16	activation	activation	NN
cord-015021-pol2qm74	4513	17	,	,	,
cord-015021-pol2qm74	4513	18	whereas	whereas	IN
cord-015021-pol2qm74	4513	19	group	group	NN
cord-015021-pol2qm74	4513	20	B	B	NNP
cord-015021-pol2qm74	4513	21	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	4513	22	a	a	DT
cord-015021-pol2qm74	4513	23	reversible	reversible	JJ
cord-015021-pol2qm74	4513	24	increase	increase	NN
cord-015021-pol2qm74	4513	25	in	in	IN
cord-015021-pol2qm74	4513	26	elastase	elastase	NN
cord-015021-pol2qm74	4513	27	.	.	.
cord-015021-pol2qm74	4514	1	Surgical	surgical	JJ
cord-015021-pol2qm74	4514	2	trauma	trauma	NN
cord-015021-pol2qm74	4514	3	caused	cause	VBN
cord-015021-pol2qm74	4514	4	in	in	IN
cord-015021-pol2qm74	4514	5	all	all	DT
cord-015021-pol2qm74	4514	6	groups	group	NNS
cord-015021-pol2qm74	4514	7	a	a	DT
cord-015021-pol2qm74	4514	8	release	release	NN
cord-015021-pol2qm74	4514	9	of	of	IN
cord-015021-pol2qm74	4514	10	PGI	PGI	NNP
cord-015021-pol2qm74	4514	11	z	z	NNP
cord-015021-pol2qm74	4514	12	and	and	CC
cord-015021-pol2qm74	4514	13	TXA	TXA	NNP
cord-015021-pol2qm74	4514	14	2	2	CD
cord-015021-pol2qm74	4514	15	which	which	WDT
cord-015021-pol2qm74	4514	16	was	be	VBD
cord-015021-pol2qm74	4514	17	more	more	RBR
cord-015021-pol2qm74	4514	18	pronounced	pronounced	JJ
cord-015021-pol2qm74	4514	19	in	in	IN
cord-015021-pol2qm74	4514	20	C	C	NNP
cord-015021-pol2qm74	4514	21	(	(	-LRB-
cord-015021-pol2qm74	4514	22	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	4514	23	)	)	-RRB-
cord-015021-pol2qm74	4514	24	and	and	CC
cord-015021-pol2qm74	4514	25	most	most	JJS
cord-015021-pol2qm74	4514	26	in	in	IN
cord-015021-pol2qm74	4514	27	B	B	NNP
cord-015021-pol2qm74	4514	28	(	(	-LRB-
cord-015021-pol2qm74	4514	29	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	4514	30	)	)	-RRB-
cord-015021-pol2qm74	4514	31	.	.	.
cord-015021-pol2qm74	4515	1	Similar	similar	JJ
cord-015021-pol2qm74	4515	2	results	result	NNS
cord-015021-pol2qm74	4515	3	were	be	VBD
cord-015021-pol2qm74	4515	4	found	find	VBN
cord-015021-pol2qm74	4515	5	for	for	IN
cord-015021-pol2qm74	4515	6	PGE~	PGE~	NNS
cord-015021-pol2qm74	4516	1	and	and	CC
cord-015021-pol2qm74	4516	2	PGF2=.	PGF2=.	NNP
cord-015021-pol2qm74	4516	3	There	there	EX
cord-015021-pol2qm74	4516	4	was	be	VBD
cord-015021-pol2qm74	4516	5	no	no	DT
cord-015021-pol2qm74	4516	6	activation	activation	NN
cord-015021-pol2qm74	4516	7	of	of	IN
cord-015021-pol2qm74	4516	8	maerophages	maerophage	NNS
cord-015021-pol2qm74	4516	9	since	since	IN
cord-015021-pol2qm74	4516	10	neopterin	neopterin	NNP
cord-015021-pol2qm74	4516	11	did	do	VBD
cord-015021-pol2qm74	4516	12	not	not	RB
cord-015021-pol2qm74	4516	13	increase	increase	VB
cord-015021-pol2qm74	4516	14	.	.	.
cord-015021-pol2qm74	4517	1	Apparently	apparently	RB
cord-015021-pol2qm74	4517	2	,	,	,
cord-015021-pol2qm74	4517	3	metabolic	metabolic	JJ
cord-015021-pol2qm74	4517	4	lung	lung	NN
cord-015021-pol2qm74	4517	5	function	function	NN
cord-015021-pol2qm74	4517	6	was	be	VBD
cord-015021-pol2qm74	4517	7	not	not	RB
cord-015021-pol2qm74	4517	8	impaired	impaired	JJ
cord-015021-pol2qm74	4517	9	because	because	IN
cord-015021-pol2qm74	4517	10	there	there	EX
cord-015021-pol2qm74	4517	11	was	be	VBD
cord-015021-pol2qm74	4517	12	no	no	DT
cord-015021-pol2qm74	4517	13	marked	marked	JJ
cord-015021-pol2qm74	4517	14	rise	rise	NN
cord-015021-pol2qm74	4517	15	in	in	IN
cord-015021-pol2qm74	4517	16	PGM	PGM	NNP
cord-015021-pol2qm74	4517	17	except	except	IN
cord-015021-pol2qm74	4517	18	in	in	IN
cord-015021-pol2qm74	4517	19	B	b	NN
cord-015021-pol2qm74	4517	20	(	(	-LRB-
cord-015021-pol2qm74	4517	21	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	4517	22	vs.	vs.	FW
cord-015021-pol2qm74	4517	23	C	C	NNP
cord-015021-pol2qm74	4517	24	)	)	-RRB-
cord-015021-pol2qm74	4517	25	.	.	.
cord-015021-pol2qm74	4518	1	Discussion	discussion	NN
cord-015021-pol2qm74	4518	2	:	:	:
cord-015021-pol2qm74	4519	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	4519	2	results	result	NNS
cord-015021-pol2qm74	4519	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	4519	4	that	that	IN
cord-015021-pol2qm74	4519	5	lung	lung	NN
cord-015021-pol2qm74	4519	6	tissue	tissue	NN
cord-015021-pol2qm74	4519	7	injury	injury	NN
cord-015021-pol2qm74	4519	8	aggravates	aggravate	VBZ
cord-015021-pol2qm74	4519	9	the	the	DT
cord-015021-pol2qm74	4519	10	mediator	mediator	NN
cord-015021-pol2qm74	4519	11	release	release	NN
cord-015021-pol2qm74	4519	12	induced	induce	VBN
cord-015021-pol2qm74	4519	13	by	by	IN
cord-015021-pol2qm74	4519	14	thoracic	thoracic	JJ
cord-015021-pol2qm74	4519	15	traum	traum	NNP
cord-015021-pol2qm74	4519	16	.	.	.
cord-015021-pol2qm74	4520	1	These	these	DT
cord-015021-pol2qm74	4520	2	mediators	mediator	NNS
cord-015021-pol2qm74	4520	3	among	among	IN
cord-015021-pol2qm74	4520	4	others	other	NNS
cord-015021-pol2qm74	4520	5	are	be	VBP
cord-015021-pol2qm74	4520	6	able	able	JJ
cord-015021-pol2qm74	4520	7	to	to	TO
cord-015021-pol2qm74	4520	8	increase	increase	VB
cord-015021-pol2qm74	4520	9	capillary	capillary	JJ
cord-015021-pol2qm74	4520	10	pressure	pressure	NN
cord-015021-pol2qm74	4520	11	and	and	CC
cord-015021-pol2qm74	4520	12	hence	hence	RB
cord-015021-pol2qm74	4520	13	lung	lung	NN
cord-015021-pol2qm74	4520	14	edema	edema	NN
cord-015021-pol2qm74	4520	15	formation	formation	NN
cord-015021-pol2qm74	4520	16	.	.	.
cord-015021-pol2qm74	4521	1	Impairment	impairment	NN
cord-015021-pol2qm74	4521	2	of	of	IN
cord-015021-pol2qm74	4521	3	lung	lung	NN
cord-015021-pol2qm74	4521	4	function	function	NN
cord-015021-pol2qm74	4521	5	,	,	,
cord-015021-pol2qm74	4521	6	however	however	RB
cord-015021-pol2qm74	4521	7	,	,	,
cord-015021-pol2qm74	4521	8	seems	seem	VBZ
cord-015021-pol2qm74	4521	9	dependent	dependent	JJ
cord-015021-pol2qm74	4521	10	on	on	IN
cord-015021-pol2qm74	4521	11	the	the	DT
cord-015021-pol2qm74	4521	12	extent	extent	NN
cord-015021-pol2qm74	4521	13	of	of	IN
cord-015021-pol2qm74	4521	14	the	the	DT
cord-015021-pol2qm74	4521	15	liberation	liberation	NN
cord-015021-pol2qm74	4521	16	.	.	.
cord-015021-pol2qm74	4522	1	Therefore	therefore	RB
cord-015021-pol2qm74	4522	2	,	,	,
cord-015021-pol2qm74	4522	3	the	the	DT
cord-015021-pol2qm74	4522	4	maximal	maximal	JJ
cord-015021-pol2qm74	4522	5	release	release	NN
cord-015021-pol2qm74	4522	6	reactions	reaction	NNS
cord-015021-pol2qm74	4522	7	occured	occur	VBD
cord-015021-pol2qm74	4522	8	in	in	IN
cord-015021-pol2qm74	4522	9	group	group	NN
cord-015021-pol2qm74	4522	10	B	B	NNP
cord-015021-pol2qm74	4522	11	and	and	CC
cord-015021-pol2qm74	4522	12	C	C	NNP
cord-015021-pol2qm74	4522	13	after	after	IN
cord-015021-pol2qm74	4522	14	lung	lung	NN
cord-015021-pol2qm74	4522	15	tissue	tissue	NN
cord-015021-pol2qm74	4522	16	resection	resection	NN
cord-015021-pol2qm74	4522	17	,	,	,
cord-015021-pol2qm74	4522	18	whereas	whereas	IN
cord-015021-pol2qm74	4522	19	the	the	DT
cord-015021-pol2qm74	4522	20	controls	control	NNS
cord-015021-pol2qm74	4522	21	showed	show	VBD
cord-015021-pol2qm74	4522	22	the	the	DT
cord-015021-pol2qm74	4522	23	highest	high	JJS
cord-015021-pol2qm74	4522	24	levels	level	NNS
cord-015021-pol2qm74	4522	25	immediately	immediately	RB
cord-015021-pol2qm74	4522	26	after	after	IN
cord-015021-pol2qm74	4522	27	the	the	DT
cord-015021-pol2qm74	4522	28	incision	incision	NN
cord-015021-pol2qm74	4522	29	.	.	.
cord-015021-pol2qm74	4523	1	We	-PRON-	PRP
cord-015021-pol2qm74	4523	2	conclude	conclude	VBP
cord-015021-pol2qm74	4523	3	that	that	IN
cord-015021-pol2qm74	4523	4	thoracoscopic	thoracoscopic	NNP
cord-015021-pol2qm74	4523	5	procedures	procedure	NNS
cord-015021-pol2qm74	4523	6	are	be	VBP
cord-015021-pol2qm74	4523	7	superior	superior	JJ
cord-015021-pol2qm74	4523	8	in	in	IN
cord-015021-pol2qm74	4523	9	reducing	reduce	VBG
cord-015021-pol2qm74	4523	10	the	the	DT
cord-015021-pol2qm74	4523	11	resection	resection	NN
cord-015021-pol2qm74	4523	12	trauma	trauma	NN
cord-015021-pol2qm74	4523	13	per	per	IN
cord-015021-pol2qm74	4523	14	se	se	FW
cord-015021-pol2qm74	4523	15	and	and	CC
cord-015021-pol2qm74	4523	16	hence	hence	RB
cord-015021-pol2qm74	4523	17	might	may	MD
cord-015021-pol2qm74	4523	18	prevent	prevent	VB
cord-015021-pol2qm74	4523	19	severe	severe	JJ
cord-015021-pol2qm74	4523	20	mediamr	mediamr	NN
cord-015021-pol2qm74	4523	21	-	-	HYPH
cord-015021-pol2qm74	4523	22	induced	induce	VBN
cord-015021-pol2qm74	4523	23	(	(	-LRB-
cord-015021-pol2qm74	4523	24	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4523	25	/	/	SYM
cord-015021-pol2qm74	4523	26	systemic	systemic	JJ
cord-015021-pol2qm74	4523	27	)	)	-RRB-
cord-015021-pol2qm74	4523	28	sequelae	sequela	NNS
cord-015021-pol2qm74	4523	29	.	.	.
cord-015021-pol2qm74	4524	1	In	in	IN
cord-015021-pol2qm74	4524	2	a	a	DT
cord-015021-pol2qm74	4524	3	prospective	prospective	JJ
cord-015021-pol2qm74	4524	4	study	study	NN
cord-015021-pol2qm74	4524	5	we	-PRON-	PRP
cord-015021-pol2qm74	4524	6	investigated	investigate	VBD
cord-015021-pol2qm74	4524	7	45	45	CD
cord-015021-pol2qm74	4524	8	patients	patient	NNS
cord-015021-pol2qm74	4524	9	using	use	VBG
cord-015021-pol2qm74	4524	10	radiochemical	radiochemical	JJ
cord-015021-pol2qm74	4524	11	method	method	NN
cord-015021-pol2qm74	4524	12	according	accord	VBG
cord-015021-pol2qm74	4524	13	to	to	IN
cord-015021-pol2qm74	4524	14	Sch	Sch	NNP
cord-015021-pol2qm74	4524	15	~	~	NNP
cord-015021-pol2qm74	4524	16	dlich	dlich	NNP
cord-015021-pol2qm74	4524	17	(	(	-LRB-
cord-015021-pol2qm74	4524	18	S	S	NNP
cord-015021-pol2qm74	4524	19	)	)	-RRB-
cord-015021-pol2qm74	4524	20	and	and	CC
cord-015021-pol2qm74	4524	21	photometric	photometric	JJ
cord-015021-pol2qm74	4524	22	method	method	NN
cord-015021-pol2qm74	4524	23	according	accord	VBG
cord-015021-pol2qm74	4524	24	to	to	IN
cord-015021-pol2qm74	4524	25	Hoffmann	Hoffmann	NNP
cord-015021-pol2qm74	4524	26	(	(	-LRB-
cord-015021-pol2qm74	4524	27	H	H	NNP
cord-015021-pol2qm74	4524	28	)	)	-RRB-
cord-015021-pol2qm74	4524	29	.	.	.
cord-015021-pol2qm74	4525	1	Serum	serum	NN
cord-015021-pol2qm74	4525	2	of	of	IN
cord-015021-pol2qm74	4525	3	severly	severly	RB
cord-015021-pol2qm74	4525	4	traumatized	traumatize	VBN
cord-015021-pol2qm74	4525	5	patients	patient	NNS
cord-015021-pol2qm74	4525	6	was	be	VBD
cord-015021-pol2qm74	4525	7	withdrawn	withdraw	VBN
cord-015021-pol2qm74	4525	8	directly	directly	RB
cord-015021-pol2qm74	4525	9	after	after	IN
cord-015021-pol2qm74	4525	10	admission	admission	NN
cord-015021-pol2qm74	4525	11	at	at	IN
cord-015021-pol2qm74	4525	12	our	-PRON-	PRP$
cord-015021-pol2qm74	4525	13	emergency	emergency	NN
cord-015021-pol2qm74	4525	14	room	room	NN
cord-015021-pol2qm74	4525	15	and	and	CC
cord-015021-pol2qm74	4525	16	in	in	IN
cord-015021-pol2qm74	4525	17	narrow	narrow	JJ
cord-015021-pol2qm74	4525	18	time	time	NN
cord-015021-pol2qm74	4525	19	intervals	interval	NNS
cord-015021-pol2qm74	4525	20	during	during	IN
cord-015021-pol2qm74	4525	21	first	first	JJ
cord-015021-pol2qm74	4525	22	24	24	CD
cord-015021-pol2qm74	4525	23	hours	hour	NNS
cord-015021-pol2qm74	4525	24	after	after	IN
cord-015021-pol2qm74	4525	25	trauma	trauma	NN
cord-015021-pol2qm74	4525	26	.	.	.
cord-015021-pol2qm74	4526	1	Follow	follow	VB
cord-015021-pol2qm74	4526	2	up	up	RP
cord-015021-pol2qm74	4527	1	control	control	NN
cord-015021-pol2qm74	4527	2	samples	sample	NNS
cord-015021-pol2qm74	4527	3	were	be	VBD
cord-015021-pol2qm74	4527	4	taken	take	VBN
cord-015021-pol2qm74	4527	5	daily	daily	RB
cord-015021-pol2qm74	4527	6	until	until	IN
cord-015021-pol2qm74	4527	7	day	day	NN
cord-015021-pol2qm74	4527	8	ten	ten	CD
cord-015021-pol2qm74	4527	9	.	.	.
cord-015021-pol2qm74	4528	1	Whereas	whereas	IN
cord-015021-pol2qm74	4528	2	no	no	DT
cord-015021-pol2qm74	4528	3	elevated	elevated	JJ
cord-015021-pol2qm74	4528	4	PLA	pla	NN
cord-015021-pol2qm74	4528	5	-	-	HYPH
cord-015021-pol2qm74	4528	6	CA	CA	NNP
cord-015021-pol2qm74	4528	7	was	be	VBD
cord-015021-pol2qm74	4528	8	found	find	VBN
cord-015021-pol2qm74	4528	9	during	during	IN
cord-015021-pol2qm74	4528	10	first	first	JJ
cord-015021-pol2qm74	4528	11	24	24	CD
cord-015021-pol2qm74	4528	12	hours	hour	NNS
cord-015021-pol2qm74	4528	13	,	,	,
cord-015021-pol2qm74	4528	14	a	a	DT
cord-015021-pol2qm74	4528	15	peak	peak	NN
cord-015021-pol2qm74	4528	16	was	be	VBD
cord-015021-pol2qm74	4528	17	regularly	regularly	RB
cord-015021-pol2qm74	4528	18	observed	observe	VBN
cord-015021-pol2qm74	4528	19	around	around	IN
cord-015021-pol2qm74	4528	20	day	day	NN
cord-015021-pol2qm74	4528	21	four	four	CD
cord-015021-pol2qm74	4528	22	.	.	.
cord-015021-pol2qm74	4529	1	There	there	EX
cord-015021-pol2qm74	4529	2	was	be	VBD
cord-015021-pol2qm74	4529	3	high	high	JJ
cord-015021-pol2qm74	4529	4	correlation	correlation	NN
cord-015021-pol2qm74	4529	5	between	between	IN
cord-015021-pol2qm74	4529	6	PLA	PLA	NNP
cord-015021-pol2qm74	4529	7	-	-	HYPH
cord-015021-pol2qm74	4529	8	CA	CA	NNP
cord-015021-pol2qm74	4529	9	and	and	CC
cord-015021-pol2qm74	4529	10	ISS	ISS	NNP
cord-015021-pol2qm74	4529	11	(	(	-LRB-
cord-015021-pol2qm74	4529	12	r=0.71	r=0.71	NNP
cord-015021-pol2qm74	4529	13	,	,	,
cord-015021-pol2qm74	4530	1	p	p	NN
cord-015021-pol2qm74	4530	2	<	<	XX
cord-015021-pol2qm74	4530	3	O.O001	o.o001	XX
cord-015021-pol2qm74	4530	4	)	)	-RRB-
cord-015021-pol2qm74	4530	5	except	except	IN
cord-015021-pol2qm74	4530	6	patients	patient	NNS
cord-015021-pol2qm74	4530	7	suffering	suffer	VBG
cord-015021-pol2qm74	4530	8	from	from	IN
cord-015021-pol2qm74	4530	9	thoracic	thoracic	JJ
cord-015021-pol2qm74	4530	10	trauma	trauma	NN
cord-015021-pol2qm74	4530	11	,	,	,
cord-015021-pol2qm74	4530	12	Thoracic	thoracic	JJ
cord-015021-pol2qm74	4530	13	trauma	trauma	NN
cord-015021-pol2qm74	4530	14	{	{	-LRB-
cord-015021-pol2qm74	4530	15	TT	TT	NNP
cord-015021-pol2qm74	4530	16	)	)	-RRB-
cord-015021-pol2qm74	4530	17	provoked	provoke	VBD
cord-015021-pol2qm74	4530	18	similar	similar	JJ
cord-015021-pol2qm74	4530	19	gons	gon	NNS
cord-015021-pol2qm74	4530	20	-	-	HYPH
cord-015021-pol2qm74	4530	21	score	score	NN
cord-015021-pol2qm74	4530	22	-	-	HYPH
cord-015021-pol2qm74	4530	23	and	and	CC
cord-015021-pol2qm74	4530	24	PLA	PLA	NNP
cord-015021-pol2qm74	4530	25	-	-	HYPH
cord-015021-pol2qm74	4530	26	CA	ca	NN
cord-015021-pol2qm74	4530	27	-	-	HYPH
cord-015021-pol2qm74	4530	28	values	value	NNS
cord-015021-pol2qm74	4530	29	compared	compare	VBN
cord-015021-pol2qm74	4530	30	to	to	IN
cord-015021-pol2qm74	4530	31	multiple	multiple	JJ
cord-015021-pol2qm74	4530	32	trauma	trauma	NN
cord-015021-pol2qm74	4530	33	(	(	-LRB-
cord-015021-pol2qm74	4530	34	MT	MT	NNP
cord-015021-pol2qm74	4530	35	)	)	-RRB-
cord-015021-pol2qm74	4530	36	despite	despite	IN
cord-015021-pol2qm74	4530	37	significantly	significantly	RB
cord-015021-pol2qm74	4530	38	lower	low	JJR
cord-015021-pol2qm74	4530	39	ISS	ISS	NNP
cord-015021-pol2qm74	4530	40	:	:	:
cord-015021-pol2qm74	4530	41	PLA	PLA	NNP
cord-015021-pol2qm74	4530	42	-	-	HYPH
cord-015021-pol2qm74	4530	43	CA	CA	NNP
cord-015021-pol2qm74	4530	44	(	(	-LRB-
cord-015021-pol2qm74	4530	45	H	H	NNP
cord-015021-pol2qm74	4530	46	)	)	-RRB-
cord-015021-pol2qm74	4530	47	MT	MT	NNP
cord-015021-pol2qm74	4530	48	32.9	32.9	CD
cord-015021-pol2qm74	4530	49	+	+	SYM
cord-015021-pol2qm74	4530	50	6.4	6.4	CD
cord-015021-pol2qm74	4530	51	TT	TT	NNP
cord-015021-pol2qm74	4530	52	28,7	28,7	CD
cord-015021-pol2qm74	4531	1	+	+	CC
cord-015021-pol2qm74	4531	2	_	_	NN
cord-015021-pol2qm74	4531	3	9,5	9,5	NNP
cord-015021-pol2qm74	4531	4	n.s	n.s	NNP
cord-015021-pol2qm74	4531	5	.	.	.
cord-015021-pol2qm74	4531	6	PLA	PLA	NNP
cord-015021-pol2qm74	4531	7	-	-	HYPH
cord-015021-pol2qm74	4531	8	CA(S	ca(s	JJ
cord-015021-pol2qm74	4531	9	)	)	-RRB-
cord-015021-pol2qm74	4531	10	MT	MT	NNP
cord-015021-pol2qm74	4531	11	11.7	11.7	CD
cord-015021-pol2qm74	4532	1	+	+	CC
cord-015021-pol2qm74	4532	2	_	_	NN
cord-015021-pol2qm74	4533	1	2.6	2.6	CD
cord-015021-pol2qm74	4533	2	TT8.3	TT8.3	NNP
cord-015021-pol2qm74	4533	3	_	_	NNP
cord-015021-pol2qm74	4533	4	+	+	SYM
cord-015021-pol2qm74	4533	5	2.6	2.6	CD
cord-015021-pol2qm74	4533	6	n.s	n.s	NN
cord-015021-pol2qm74	4533	7	.	.	.
cord-015021-pol2qm74	4533	8	Goris	Goris	NNP
cord-015021-pol2qm74	4533	9	MT	MT	NNP
cord-015021-pol2qm74	4533	10	3.5	3.5	CD
cord-015021-pol2qm74	4533	11	4	4	CD
cord-015021-pol2qm74	4533	12	-	-	SYM
cord-015021-pol2qm74	4533	13	0.7	0.7	CD
cord-015021-pol2qm74	4534	1	TT3.6	TT3.6	NNP
cord-015021-pol2qm74	4534	2	_	_	NNP
cord-015021-pol2qm74	4534	3	+	+	CC
cord-015021-pol2qm74	4534	4	1.3	1.3	CD
cord-015021-pol2qm74	4534	5	n.s	n.s	NNP
cord-015021-pol2qm74	4534	6	.	.	NNP
cord-015021-pol2qm74	4534	7	ISS	ISS	NNP
cord-015021-pol2qm74	4534	8	MT	MT	NNP
cord-015021-pol2qm74	4534	9	35	35	CD
cord-015021-pol2qm74	4534	10	4	4	CD
cord-015021-pol2qm74	4534	11	-	-	SYM
cord-015021-pol2qm74	4534	12	3	3	CD
cord-015021-pol2qm74	4534	13	TT21	TT21	NNP
cord-015021-pol2qm74	4534	14	4	4	CD
cord-015021-pol2qm74	4534	15	-	-	SYM
cord-015021-pol2qm74	4534	16	3	3	CD
cord-015021-pol2qm74	4534	17	p<0.01	p<0.01	NN
cord-015021-pol2qm74	4535	1	We	-PRON-	PRP
cord-015021-pol2qm74	4535	2	found	find	VBD
cord-015021-pol2qm74	4535	3	delayed	delayed	JJ
cord-015021-pol2qm74	4535	4	elevation	elevation	NN
cord-015021-pol2qm74	4535	5	of	of	IN
cord-015021-pol2qm74	4535	6	PLA	PLA	NNP
cord-015021-pol2qm74	4535	7	-	-	HYPH
cord-015021-pol2qm74	4535	8	CA	CA	NNP
cord-015021-pol2qm74	4535	9	after	after	IN
cord-015021-pol2qm74	4535	10	severe	severe	JJ
cord-015021-pol2qm74	4535	11	trauma	trauma	NN
cord-015021-pol2qm74	4535	12	,	,	,
cord-015021-pol2qm74	4536	1	However	however	RB
cord-015021-pol2qm74	4536	2	detection	detection	NN
cord-015021-pol2qm74	4536	3	of	of	IN
cord-015021-pol2qm74	4536	4	delayed	delay	VBN
cord-015021-pol2qm74	4536	5	PLA	PLA	NNP
cord-015021-pol2qm74	4536	6	-	-	HYPH
cord-015021-pol2qm74	4536	7	CA	CA	NNP
cord-015021-pol2qm74	4536	8	in	in	IN
cord-015021-pol2qm74	4536	9	the	the	DT
cord-015021-pol2qm74	4536	10	serum	serum	NN
cord-015021-pol2qm74	4536	11	of	of	IN
cord-015021-pol2qm74	4536	12	traumatized	traumatize	VBN
cord-015021-pol2qm74	4536	13	patients	patient	NNS
cord-015021-pol2qm74	4536	14	can	can	MD
cord-015021-pol2qm74	4536	15	not	not	RB
cord-015021-pol2qm74	4536	16	give	give	VB
cord-015021-pol2qm74	4536	17	reliable	reliable	JJ
cord-015021-pol2qm74	4536	18	information	information	NN
cord-015021-pol2qm74	4536	19	about	about	IN
cord-015021-pol2qm74	4536	20	the	the	DT
cord-015021-pol2qm74	4536	21	exact	exact	JJ
cord-015021-pol2qm74	4536	22	role	role	NN
cord-015021-pol2qm74	4536	23	of	of	IN
cord-015021-pol2qm74	4536	24	PLA	PLA	NNP
cord-015021-pol2qm74	4536	25	in	in	IN
cord-015021-pol2qm74	4536	26	the	the	DT
cord-015021-pol2qm74	4536	27	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4536	28	reaction	reaction	NN
cord-015021-pol2qm74	4536	29	after	after	IN
cord-015021-pol2qm74	4536	30	trauma	trauma	NN
cord-015021-pol2qm74	4536	31	as	as	IN
cord-015021-pol2qm74	4536	32	latest	late	JJS
cord-015021-pol2qm74	4536	33	results	result	NNS
cord-015021-pol2qm74	4536	34	show	show	VBP
cord-015021-pol2qm74	4536	35	that	that	IN
cord-015021-pol2qm74	4536	36	PLA	PLA	NNP
cord-015021-pol2qm74	4536	37	is	be	VBZ
cord-015021-pol2qm74	4536	38	secreted	secrete	VBN
cord-015021-pol2qm74	4536	39	early	early	RB
cord-015021-pol2qm74	4536	40	but	but	CC
cord-015021-pol2qm74	4536	41	bound	bind	VBN
cord-015021-pol2qm74	4536	42	at	at	IN
cord-015021-pol2qm74	4536	43	lipophilic	lipophilic	JJ
cord-015021-pol2qm74	4536	44	sites	site	NNS
cord-015021-pol2qm74	4536	45	of	of	IN
cord-015021-pol2qm74	4536	46	vascular	vascular	JJ
cord-015021-pol2qm74	4536	47	membranes	membrane	NNS
cord-015021-pol2qm74	4536	48	.	.	.
cord-015021-pol2qm74	4537	1	Hern	Hern	NNP
cord-015021-pol2qm74	4537	2	~	~	NFP
cord-015021-pol2qm74	4537	3	mdez	mdez	NNP
cord-015021-pol2qm74	4537	4	M	M	NNP
cord-015021-pol2qm74	4537	5	J	J	NNP
cord-015021-pol2qm74	4537	6	,	,	,
cord-015021-pol2qm74	4537	7	Amiguet	Amiguet	NNP
cord-015021-pol2qm74	4537	8	JA	JA	NNP
cord-015021-pol2qm74	4537	9	,	,	,
cord-015021-pol2qm74	4537	10	Monreal	Monreal	NNP
cord-015021-pol2qm74	4537	11	JI	JI	NNP
cord-015021-pol2qm74	4537	12	,	,	,
cord-015021-pol2qm74	4537	13	Vid	vid	NN
cord-015021-pol2qm74	4537	14	~	~	NFP
cord-015021-pol2qm74	4537	15	n	n	NNP
cord-015021-pol2qm74	4537	16	JR	JR	NNP
cord-015021-pol2qm74	4537	17	,	,	,
cord-015021-pol2qm74	4537	18	Jim6nez	Jim6nez	NNP
cord-015021-pol2qm74	4537	19	F	F	NNP
cord-015021-pol2qm74	4537	20	J	J	NNP
cord-015021-pol2qm74	4537	21	,	,	,
cord-015021-pol2qm74	4537	22	L6pez	L6pez	NNP
cord-015021-pol2qm74	4537	23	-	-	HYPH
cord-015021-pol2qm74	4537	24	Vivanco	Vivanco	NNP
cord-015021-pol2qm74	4537	25	G	G	NNP
cord-015021-pol2qm74	4537	26	Acute	acute	NN
cord-015021-pol2qm74	4537	27	phase	phase	NN
cord-015021-pol2qm74	4537	28	reactant	reactant	NN
cord-015021-pol2qm74	4537	29	proteins	protein	NNS
cord-015021-pol2qm74	4537	30	increment	increment	NN
cord-015021-pol2qm74	4537	31	in	in	IN
cord-015021-pol2qm74	4537	32	serum	serum	NN
cord-015021-pol2qm74	4537	33	of	of	IN
cord-015021-pol2qm74	4537	34	patients	patient	NNS
cord-015021-pol2qm74	4537	35	with	with	IN
cord-015021-pol2qm74	4537	36	traumatisms	traumatism	NNS
cord-015021-pol2qm74	4537	37	and	and	CC
cord-015021-pol2qm74	4537	38	inflammation	inflammation	NN
cord-015021-pol2qm74	4537	39	has	have	VBZ
cord-015021-pol2qm74	4537	40	been	be	VBN
cord-015021-pol2qm74	4537	41	previously	previously	RB
cord-015021-pol2qm74	4537	42	reported	report	VBN
cord-015021-pol2qm74	4537	43	.	.	.
cord-015021-pol2qm74	4538	1	Alpha-1	alpha-1	JJ
cord-015021-pol2qm74	4538	2	antitrypsin	antitrypsin	NN
cord-015021-pol2qm74	4538	3	(	(	-LRB-
cord-015021-pol2qm74	4538	4	AAT	AAT	NNP
cord-015021-pol2qm74	4538	5	)	)	-RRB-
cord-015021-pol2qm74	4538	6	,	,	.
cord-015021-pol2qm74	4539	1	Alpha-2	Alpha-2	NNP
cord-015021-pol2qm74	4539	2	macroglobulin	macroglobulin	NNP
cord-015021-pol2qm74	4539	3	(	(	-LRB-
cord-015021-pol2qm74	4539	4	AMG	AMG	NNP
cord-015021-pol2qm74	4539	5	)	)	-RRB-
cord-015021-pol2qm74	4539	6	and	and	CC
cord-015021-pol2qm74	4539	7	Ceruloplasmin	Ceruloplasmin	NNP
cord-015021-pol2qm74	4539	8	(	(	-LRB-
cord-015021-pol2qm74	4539	9	Cp	Cp	NNP
cord-015021-pol2qm74	4539	10	)	)	-RRB-
cord-015021-pol2qm74	4539	11	are	be	VBP
cord-015021-pol2qm74	4539	12	evaluated	evaluate	VBN
cord-015021-pol2qm74	4539	13	in	in	IN
cord-015021-pol2qm74	4539	14	the	the	DT
cord-015021-pol2qm74	4539	15	following	following	NN
cord-015021-pol2qm74	4539	16	of	of	IN
cord-015021-pol2qm74	4539	17	33	33	CD
cord-015021-pol2qm74	4539	18	patients	patient	NNS
cord-015021-pol2qm74	4539	19	,	,	,
cord-015021-pol2qm74	4539	20	27	27	CD
cord-015021-pol2qm74	4539	21	males	male	NNS
cord-015021-pol2qm74	4539	22	and	and	CC
cord-015021-pol2qm74	4539	23	6	6	CD
cord-015021-pol2qm74	4539	24	females	female	NNS
cord-015021-pol2qm74	4539	25	(	(	-LRB-
cord-015021-pol2qm74	4539	26	mean	mean	VB
cord-015021-pol2qm74	4539	27	age	age	NN
cord-015021-pol2qm74	4539	28	:	:	:
cord-015021-pol2qm74	4539	29	43	43	CD
cord-015021-pol2qm74	4539	30	years	year	NNS
cord-015021-pol2qm74	4539	31	)	)	-RRB-
cord-015021-pol2qm74	4539	32	,	,	,
cord-015021-pol2qm74	4539	33	with	with	IN
cord-015021-pol2qm74	4539	34	compound	compound	NN
cord-015021-pol2qm74	4539	35	fractures	fracture	NNS
cord-015021-pol2qm74	4539	36	.	.	.
cord-015021-pol2qm74	4540	1	57	57	CD
cord-015021-pol2qm74	4540	2	%	%	NN
cord-015021-pol2qm74	4540	3	of	of	IN
cord-015021-pol2qm74	4540	4	them	-PRON-	PRP
cord-015021-pol2qm74	4540	5	were	be	VBD
cord-015021-pol2qm74	4540	6	located	locate	VBN
cord-015021-pol2qm74	4540	7	in	in	IN
cord-015021-pol2qm74	4540	8	tibia	tibia	NN
cord-015021-pol2qm74	4540	9	and	and	CC
cord-015021-pol2qm74	4540	10	fibula	fibula	NN
cord-015021-pol2qm74	4540	11	.	.	.
cord-015021-pol2qm74	4541	1	Intercurrent	intercurrent	NN
cord-015021-pol2qm74	4541	2	infection	infection	NN
cord-015021-pol2qm74	4541	3	developed	develop	VBD
cord-015021-pol2qm74	4541	4	in	in	IN
cord-015021-pol2qm74	4541	5	4	4	CD
cord-015021-pol2qm74	4541	6	patients	patient	NNS
cord-015021-pol2qm74	4541	7	and	and	CC
cord-015021-pol2qm74	4541	8	internal	internal	JJ
cord-015021-pol2qm74	4541	9	fixation	fixation	NN
cord-015021-pol2qm74	4541	10	rejection	rejection	NN
cord-015021-pol2qm74	4541	11	in	in	IN
cord-015021-pol2qm74	4541	12	one	one	CD
cord-015021-pol2qm74	4541	13	.	.	.
cord-015021-pol2qm74	4542	1	Measurements	measurement	NNS
cord-015021-pol2qm74	4542	2	were	be	VBD
cord-015021-pol2qm74	4542	3	made	make	VBN
cord-015021-pol2qm74	4542	4	by	by	IN
cord-015021-pol2qm74	4542	5	radial	radial	JJ
cord-015021-pol2qm74	4542	6	immunodiffusion	immunodiffusion	NN
cord-015021-pol2qm74	4542	7	on	on	IN
cord-015021-pol2qm74	4542	8	days	day	NNS
cord-015021-pol2qm74	4542	9	0	0	CD
cord-015021-pol2qm74	4542	10	,	,	,
cord-015021-pol2qm74	4542	11	3	3	CD
cord-015021-pol2qm74	4542	12	,	,	,
cord-015021-pol2qm74	4542	13	10	10	CD
cord-015021-pol2qm74	4542	14	,	,	,
cord-015021-pol2qm74	4542	15	17	17	CD
cord-015021-pol2qm74	4542	16	,	,	,
cord-015021-pol2qm74	4542	17	24	24	CD
cord-015021-pol2qm74	4542	18	,	,	,
cord-015021-pol2qm74	4542	19	31	31	CD
cord-015021-pol2qm74	4542	20	and	and	CC
cord-015021-pol2qm74	4542	21	38	38	CD
cord-015021-pol2qm74	4542	22	.	.	.
cord-015021-pol2qm74	4543	1	A	a	DT
cord-015021-pol2qm74	4543	2	control	control	NN
cord-015021-pol2qm74	4543	3	group	group	NN
cord-015021-pol2qm74	4543	4	of	of	IN
cord-015021-pol2qm74	4543	5	30	30	CD
cord-015021-pol2qm74	4543	6	healthy	healthy	JJ
cord-015021-pol2qm74	4543	7	volunteers	volunteer	NNS
cord-015021-pol2qm74	4543	8	was	be	VBD
cord-015021-pol2qm74	4543	9	also	also	RB
cord-015021-pol2qm74	4543	10	evaluated	evaluate	VBN
cord-015021-pol2qm74	4543	11	.	.	.
cord-015021-pol2qm74	4544	1	AAT	AAT	NNP
cord-015021-pol2qm74	4544	2	and	and	CC
cord-015021-pol2qm74	4544	3	Cp	Cp	NNP
cord-015021-pol2qm74	4544	4	showed	show	VBD
cord-015021-pol2qm74	4544	5	increased	increase	VBN
cord-015021-pol2qm74	4544	6	values	value	NNS
cord-015021-pol2qm74	4544	7	from	from	IN
cord-015021-pol2qm74	4544	8	day	day	NN
cord-015021-pol2qm74	4544	9	3	3	CD
cord-015021-pol2qm74	4544	10	which	which	WDT
cord-015021-pol2qm74	4544	11	kept	keep	VBD
cord-015021-pol2qm74	4544	12	elevated	elevate	VBN
cord-015021-pol2qm74	4544	13	untill	untill	IN
cord-015021-pol2qm74	4544	14	the	the	DT
cord-015021-pol2qm74	4544	15	end	end	NN
cord-015021-pol2qm74	4544	16	of	of	IN
cord-015021-pol2qm74	4544	17	the	the	DT
cord-015021-pol2qm74	4544	18	study	study	NN
cord-015021-pol2qm74	4544	19	.	.	.
cord-015021-pol2qm74	4545	1	AMG	AMG	NNP
cord-015021-pol2qm74	4545	2	elevated	elevate	VBD
cord-015021-pol2qm74	4545	3	from	from	IN
cord-015021-pol2qm74	4545	4	day	day	NN
cord-015021-pol2qm74	4545	5	24	24	CD
cord-015021-pol2qm74	4545	6	.	.	.
cord-015021-pol2qm74	4546	1	When	when	WRB
cord-015021-pol2qm74	4546	2	infection	infection	NN
cord-015021-pol2qm74	4546	3	developed	develop	VBD
cord-015021-pol2qm74	4546	4	,	,	,
cord-015021-pol2qm74	4546	5	AAT	AAT	NNP
cord-015021-pol2qm74	4546	6	and	and	CC
cord-015021-pol2qm74	4546	7	Cp	Cp	NNP
cord-015021-pol2qm74	4546	8	values	value	NNS
cord-015021-pol2qm74	4546	9	were	be	VBD
cord-015021-pol2qm74	4546	10	even	even	RB
cord-015021-pol2qm74	4546	11	higher	high	JJR
cord-015021-pol2qm74	4546	12	whereas	whereas	IN
cord-015021-pol2qm74	4546	13	AMG	AMG	NNP
cord-015021-pol2qm74	4546	14	values	value	NNS
cord-015021-pol2qm74	4546	15	decreased	decrease	VBD
cord-015021-pol2qm74	4546	16	.	.	.
cord-015021-pol2qm74	4547	1	Fixation	fixation	NN
cord-015021-pol2qm74	4547	2	rejection	rejection	NN
cord-015021-pol2qm74	4547	3	caused	cause	VBD
cord-015021-pol2qm74	4547	4	AAT	AAT	NNP
cord-015021-pol2qm74	4547	5	,	,	,
cord-015021-pol2qm74	4547	6	AMG	AMG	NNP
cord-015021-pol2qm74	4547	7	and	and	CC
cord-015021-pol2qm74	4547	8	Cp	Cp	NNP
cord-015021-pol2qm74	4547	9	increment	increment	NN
cord-015021-pol2qm74	4547	10	.	.	.
cord-015021-pol2qm74	4548	1	AAT	AAT	NNP
cord-015021-pol2qm74	4548	2	and	and	CC
cord-015021-pol2qm74	4548	3	Cp	Cp	NNP
cord-015021-pol2qm74	4548	4	increment	increment	VB
cord-015021-pol2qm74	4548	5	in	in	IN
cord-015021-pol2qm74	4548	6	non	non	JJ
cord-015021-pol2qm74	4548	7	complicated	complicated	JJ
cord-015021-pol2qm74	4548	8	fractures	fracture	NNS
cord-015021-pol2qm74	4548	9	might	may	MD
cord-015021-pol2qm74	4548	10	be	be	VB
cord-015021-pol2qm74	4548	11	due	due	JJ
cord-015021-pol2qm74	4548	12	to	to	IN
cord-015021-pol2qm74	4548	13	accompanying	accompany	VBG
cord-015021-pol2qm74	4548	14	inflamation	inflamation	NN
cord-015021-pol2qm74	4548	15	,	,	,
cord-015021-pol2qm74	4548	16	by	by	IN
cord-015021-pol2qm74	4548	17	means	mean	NNS
cord-015021-pol2qm74	4548	18	of	of	IN
cord-015021-pol2qm74	4548	19	cytokines	cytokine	NNS
cord-015021-pol2qm74	4548	20	release	release	NN
cord-015021-pol2qm74	4548	21	and	and	CC
cord-015021-pol2qm74	4548	22	APRPs	APRPs	NNPS
cord-015021-pol2qm74	4548	23	hepatic	hepatic	JJ
cord-015021-pol2qm74	4548	24	synthesis	synthesis	NN
cord-015021-pol2qm74	4548	25	induction	induction	NN
cord-015021-pol2qm74	4548	26	.	.	.
cord-015021-pol2qm74	4549	1	Therefore	therefore	RB
cord-015021-pol2qm74	4549	2	,	,	,
cord-015021-pol2qm74	4549	3	increment	increment	NN
cord-015021-pol2qm74	4549	4	is	be	VBZ
cord-015021-pol2qm74	4549	5	higher	high	JJR
cord-015021-pol2qm74	4549	6	when	when	WRB
cord-015021-pol2qm74	4549	7	infection	infection	NN
cord-015021-pol2qm74	4549	8	or	or	CC
cord-015021-pol2qm74	4549	9	rejection	rejection	NN
cord-015021-pol2qm74	4549	10	develop	develop	VB
cord-015021-pol2qm74	4549	11	.	.	.
cord-015021-pol2qm74	4550	1	AMG	AMG	NNP
cord-015021-pol2qm74	4550	2	behaviour	behaviour	NN
cord-015021-pol2qm74	4550	3	at	at	IN
cord-015021-pol2qm74	4550	4	early	early	JJ
cord-015021-pol2qm74	4550	5	stages	stage	NNS
cord-015021-pol2qm74	4550	6	of	of	IN
cord-015021-pol2qm74	4550	7	evolution	evolution	NN
cord-015021-pol2qm74	4550	8	is	be	VBZ
cord-015021-pol2qm74	4550	9	secondary	secondary	JJ
cord-015021-pol2qm74	4550	10	to	to	IN
cord-015021-pol2qm74	4550	11	hiperconsumption	hiperconsumption	NN
cord-015021-pol2qm74	4550	12	,	,	,
cord-015021-pol2qm74	4550	13	considering	consider	VBG
cord-015021-pol2qm74	4550	14	mean	mean	VB
cord-015021-pol2qm74	4550	15	life	life	NN
cord-015021-pol2qm74	4550	16	shortening	shorten	VBG
cord-015021-pol2qm74	4550	17	after	after	IN
cord-015021-pol2qm74	4550	18	proteases	protease	NNS
cord-015021-pol2qm74	4550	19	ligation	ligation	NN
cord-015021-pol2qm74	4550	20	.	.	.
cord-015021-pol2qm74	4551	1	AMG	AMG	NNP
cord-015021-pol2qm74	4551	2	modifications	modification	NNS
cord-015021-pol2qm74	4551	3	in	in	IN
cord-015021-pol2qm74	4551	4	fixation	fixation	NN
cord-015021-pol2qm74	4551	5	rejection	rejection	NN
cord-015021-pol2qm74	4551	6	remain	remain	VBP
cord-015021-pol2qm74	4551	7	obscure	obscure	JJ
cord-015021-pol2qm74	4551	8	.	.	.
cord-015021-pol2qm74	4552	1	APRPs	aprps	NN
cord-015021-pol2qm74	4552	2	increment	increment	NN
cord-015021-pol2qm74	4552	3	modulates	modulate	VBZ
cord-015021-pol2qm74	4552	4	inflammation	inflammation	NN
cord-015021-pol2qm74	4552	5	and	and	CC
cord-015021-pol2qm74	4552	6	bony	bony	JJ
cord-015021-pol2qm74	4552	7	callus	callus	NN
cord-015021-pol2qm74	4552	8	formation	formation	NN
cord-015021-pol2qm74	4552	9	by	by	IN
cord-015021-pol2qm74	4552	10	means	mean	VBZ
cord-015021-pol2qm74	4552	11	their	-PRON-	PRP$
cord-015021-pol2qm74	4552	12	antyprotease	antyprotease	NN
cord-015021-pol2qm74	4552	13	and	and	CC
cord-015021-pol2qm74	4552	14	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	4552	15	properties	property	NNS
cord-015021-pol2qm74	4552	16	.	.	.
cord-015021-pol2qm74	4553	1	Clinically	clinically	RB
cord-015021-pol2qm74	4553	2	,	,	,
cord-015021-pol2qm74	4553	3	APRPs	APRPs	NNP
cord-015021-pol2qm74	4553	4	might	may	MD
cord-015021-pol2qm74	4553	5	be	be	VB
cord-015021-pol2qm74	4553	6	useful	useful	JJ
cord-015021-pol2qm74	4553	7	parameters	parameter	NNS
cord-015021-pol2qm74	4553	8	in	in	IN
cord-015021-pol2qm74	4553	9	determining	determine	VBG
cord-015021-pol2qm74	4553	10	complications	complication	NNS
cord-015021-pol2qm74	4553	11	onset	onset	NN
cord-015021-pol2qm74	4553	12	in	in	IN
cord-015021-pol2qm74	4553	13	fractures	fracture	NNS
cord-015021-pol2qm74	4553	14	evolution	evolution	NN
cord-015021-pol2qm74	4553	15	.	.	.
cord-015021-pol2qm74	4554	1	Hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	4554	2	shock	shock	NN
cord-015021-pol2qm74	4554	3	(	(	-LRB-
cord-015021-pol2qm74	4554	4	HS	HS	NNP
cord-015021-pol2qm74	4554	5	)	)	-RRB-
cord-015021-pol2qm74	4554	6	is	be	VBZ
cord-015021-pol2qm74	4554	7	a	a	DT
cord-015021-pol2qm74	4554	8	common	common	JJ
cord-015021-pol2qm74	4554	9	complication	complication	NN
cord-015021-pol2qm74	4554	10	of	of	IN
cord-015021-pol2qm74	4554	11	trauma	trauma	NN
cord-015021-pol2qm74	4554	12	,	,	,
cord-015021-pol2qm74	4554	13	as	as	RB
cord-015021-pol2qm74	4554	14	well	well	RB
cord-015021-pol2qm74	4554	15	as	as	IN
cord-015021-pol2qm74	4554	16	some	some	DT
cord-015021-pol2qm74	4554	17	major	major	JJ
cord-015021-pol2qm74	4554	18	surgical	surgical	JJ
cord-015021-pol2qm74	4554	19	procedures	procedure	NNS
cord-015021-pol2qm74	4554	20	.	.	.
cord-015021-pol2qm74	4555	1	The	the	DT
cord-015021-pol2qm74	4555	2	alteration	alteration	NN
cord-015021-pol2qm74	4555	3	of	of	IN
cord-015021-pol2qm74	4555	4	the	the	DT
cord-015021-pol2qm74	4555	5	immune	immune	JJ
cord-015021-pol2qm74	4555	6	system	system	NN
cord-015021-pol2qm74	4555	7	by	by	IN
cord-015021-pol2qm74	4555	8	HS	HS	NNP
cord-015021-pol2qm74	4555	9	is	be	VBZ
cord-015021-pol2qm74	4555	10	thought	think	VBN
cord-015021-pol2qm74	4555	11	to	to	TO
cord-015021-pol2qm74	4555	12	contribute	contribute	VB
cord-015021-pol2qm74	4555	13	to	to	IN
cord-015021-pol2qm74	4555	14	the	the	DT
cord-015021-pol2qm74	4555	15	increased	increase	VBN
cord-015021-pol2qm74	4555	16	septic	septic	JJ
cord-015021-pol2qm74	4555	17	morbidity	morbidity	NN
cord-015021-pol2qm74	4555	18	and	and	CC
cord-015021-pol2qm74	4555	19	mortality	mortality	NN
cord-015021-pol2qm74	4555	20	seen	see	VBN
cord-015021-pol2qm74	4555	21	in	in	IN
cord-015021-pol2qm74	4555	22	these	these	DT
cord-015021-pol2qm74	4555	23	patients	patient	NNS
cord-015021-pol2qm74	4555	24	.	.	.
cord-015021-pol2qm74	4556	1	Multiple	multiple	JJ
cord-015021-pol2qm74	4556	2	mediators	mediator	NNS
cord-015021-pol2qm74	4556	3	are	be	VBP
cord-015021-pol2qm74	4556	4	released	release	VBN
cord-015021-pol2qm74	4556	5	following	follow	VBG
cord-015021-pol2qm74	4556	6	HS	HS	NNP
cord-015021-pol2qm74	4556	7	.	.	.
cord-015021-pol2qm74	4557	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	4557	2	,	,	,
cord-015021-pol2qm74	4557	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	4557	4	,	,	,
cord-015021-pol2qm74	4557	5	TNF	TNF	NNP
cord-015021-pol2qm74	4557	6	,	,	,
cord-015021-pol2qm74	4557	7	PGE	PGE	NNP
cord-015021-pol2qm74	4557	8	2	2	CD
cord-015021-pol2qm74	4557	9	and	and	CC
cord-015021-pol2qm74	4557	10	TGF	TGF	NNP
cord-015021-pol2qm74	4557	11	-	-	HYPH
cord-015021-pol2qm74	4557	12	B	b	NN
cord-015021-pol2qm74	4557	13	have	have	VBP
cord-015021-pol2qm74	4557	14	all	all	DT
cord-015021-pol2qm74	4557	15	been	be	VBN
cord-015021-pol2qm74	4557	16	implicated	implicate	VBN
cord-015021-pol2qm74	4557	17	in	in	IN
cord-015021-pol2qm74	4557	18	these	these	DT
cord-015021-pol2qm74	4557	19	immune	immune	JJ
cord-015021-pol2qm74	4557	20	system	system	NN
cord-015021-pol2qm74	4557	21	changes	change	NNS
cord-015021-pol2qm74	4557	22	.	.	.
cord-015021-pol2qm74	4558	1	In	in	IN
cord-015021-pol2qm74	4558	2	vitro	vitro	FW
cord-015021-pol2qm74	4558	3	,	,	,
cord-015021-pol2qm74	4558	4	PGE	PGE	NNP
cord-015021-pol2qm74	4558	5	2	2	CD
cord-015021-pol2qm74	4558	6	causes	cause	VBZ
cord-015021-pol2qm74	4558	7	many	many	JJ
cord-015021-pol2qm74	4558	8	of	of	IN
cord-015021-pol2qm74	4558	9	the	the	DT
cord-015021-pol2qm74	4558	10	immune	immune	JJ
cord-015021-pol2qm74	4558	11	system	system	NN
cord-015021-pol2qm74	4558	12	changes	change	VBZ
cord-015021-pol2qm74	4558	13	following	follow	VBG
cord-015021-pol2qm74	4558	14	HS	HS	NNP
cord-015021-pol2qm74	4558	15	,	,	,
cord-015021-pol2qm74	4558	16	yet	yet	CC
cord-015021-pol2qm74	4558	17	the	the	DT
cord-015021-pol2qm74	4558	18	time	time	NN
cord-015021-pol2qm74	4558	19	course	course	NN
cord-015021-pol2qm74	4558	20	of	of	IN
cord-015021-pol2qm74	4558	21	PGE	PGE	NNP
cord-015021-pol2qm74	4558	22	2	2	CD
cord-015021-pol2qm74	4558	23	release	release	NN
cord-015021-pol2qm74	4558	24	has	have	VBZ
cord-015021-pol2qm74	4558	25	not	not	RB
cord-015021-pol2qm74	4558	26	been	be	VBN
cord-015021-pol2qm74	4558	27	well	well	RB
cord-015021-pol2qm74	4558	28	deliniated	deliniate	VBN
cord-015021-pol2qm74	4558	29	.	.	.
cord-015021-pol2qm74	4559	1	The	the	DT
cord-015021-pol2qm74	4559	2	aim	aim	NN
cord-015021-pol2qm74	4559	3	of	of	IN
cord-015021-pol2qm74	4559	4	this	this	DT
cord-015021-pol2qm74	4559	5	study	study	NN
cord-015021-pol2qm74	4559	6	was	be	VBD
cord-015021-pol2qm74	4559	7	to	to	TO
cord-015021-pol2qm74	4559	8	determine	determine	VB
cord-015021-pol2qm74	4559	9	the	the	DT
cord-015021-pol2qm74	4559	10	time	time	NN
cord-015021-pol2qm74	4559	11	course	course	NN
cord-015021-pol2qm74	4559	12	of	of	IN
cord-015021-pol2qm74	4559	13	PGE	PGE	NNP
cord-015021-pol2qm74	4559	14	2	2	CD
cord-015021-pol2qm74	4559	15	release	release	NN
cord-015021-pol2qm74	4559	16	by	by	IN
cord-015021-pol2qm74	4559	17	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4559	18	and	and	CC
cord-015021-pol2qm74	4559	19	splenic	splenic	JJ
cord-015021-pol2qm74	4559	20	macrophages	macrophage	NNS
cord-015021-pol2qm74	4559	21	following	follow	VBG
cord-015021-pol2qm74	4559	22	HS	HS	NNP
cord-015021-pol2qm74	4559	23	.	.	.
cord-015021-pol2qm74	4560	1	C3H	C3H	NNP
cord-015021-pol2qm74	4560	2	/	/	SYM
cord-015021-pol2qm74	4560	3	HEN	HEN	NNP
cord-015021-pol2qm74	4560	4	mice	mouse	NNS
cord-015021-pol2qm74	4560	5	were	be	VBD
cord-015021-pol2qm74	4560	6	bled	bleed	VBN
cord-015021-pol2qm74	4560	7	to	to	IN
cord-015021-pol2qm74	4560	8	a	a	DT
cord-015021-pol2qm74	4560	9	mean	mean	JJ
cord-015021-pol2qm74	4560	10	BP	BP	NNP
cord-015021-pol2qm74	4560	11	of	of	IN
cord-015021-pol2qm74	4560	12	35	35	CD
cord-015021-pol2qm74	4560	13	+	+	SYM
cord-015021-pol2qm74	4560	14	5	5	CD
cord-015021-pol2qm74	4560	15	mm	mm	NN
cord-015021-pol2qm74	4561	1	Hg	Hg	NNP
cord-015021-pol2qm74	4561	2	for	for	IN
cord-015021-pol2qm74	4561	3	60	60	CD
cord-015021-pol2qm74	4561	4	minutes	minute	NNS
cord-015021-pol2qm74	4561	5	.	.	.
cord-015021-pol2qm74	4562	1	The	the	DT
cord-015021-pol2qm74	4562	2	animals	animal	NNS
cord-015021-pol2qm74	4562	3	were	be	VBD
cord-015021-pol2qm74	4562	4	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	4562	5	with	with	IN
cord-015021-pol2qm74	4562	6	the	the	DT
cord-015021-pol2qm74	4562	7	shed	shed	JJ
cord-015021-pol2qm74	4562	8	blood	blood	NN
cord-015021-pol2qm74	4562	9	and	and	CC
cord-015021-pol2qm74	4562	10	normal	normal	JJ
cord-015021-pol2qm74	4562	11	saline	saline	NN
cord-015021-pol2qm74	4562	12	.	.	.
cord-015021-pol2qm74	4563	1	Control	control	NN
cord-015021-pol2qm74	4563	2	animals	animal	NNS
cord-015021-pol2qm74	4563	3	were	be	VBD
cord-015021-pol2qm74	4563	4	cannalated	cannalate	VBN
cord-015021-pol2qm74	4563	5	,	,	,
cord-015021-pol2qm74	4563	6	but	but	CC
cord-015021-pol2qm74	4563	7	blood	blood	NN
cord-015021-pol2qm74	4563	8	was	be	VBD
cord-015021-pol2qm74	4563	9	not	not	RB
cord-015021-pol2qm74	4563	10	withdrawn	withdraw	VBN
cord-015021-pol2qm74	4563	11	.	.	.
cord-015021-pol2qm74	4564	1	The	the	DT
cord-015021-pol2qm74	4564	2	animals	animal	NNS
cord-015021-pol2qm74	4564	3	were	be	VBD
cord-015021-pol2qm74	4564	4	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	4564	5	at	at	IN
cord-015021-pol2qm74	4564	6	2	2	CD
cord-015021-pol2qm74	4564	7	,	,	,
cord-015021-pol2qm74	4564	8	12	12	CD
cord-015021-pol2qm74	4564	9	,	,	,
cord-015021-pol2qm74	4564	10	24	24	CD
cord-015021-pol2qm74	4564	11	,	,	,
cord-015021-pol2qm74	4564	12	48	48	CD
cord-015021-pol2qm74	4564	13	,	,	,
cord-015021-pol2qm74	4564	14	and	and	CC
cord-015021-pol2qm74	4564	15	72	72	CD
cord-015021-pol2qm74	4564	16	hours	hour	NNS
cord-015021-pol2qm74	4564	17	following	follow	VBG
cord-015021-pol2qm74	4564	18	HS	HS	NNP
cord-015021-pol2qm74	4564	19	.	.	.
cord-015021-pol2qm74	4565	1	Peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4565	2	and	and	CC
cord-015021-pol2qm74	4565	3	splenic	splenic	JJ
cord-015021-pol2qm74	4565	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	4565	5	were	be	VBD
cord-015021-pol2qm74	4565	6	harvested	harvest	VBN
cord-015021-pol2qm74	4565	7	from	from	IN
cord-015021-pol2qm74	4565	8	each	each	DT
cord-015021-pol2qm74	4565	9	animal	animal	NN
cord-015021-pol2qm74	4565	10	and	and	CC
cord-015021-pol2qm74	4565	11	cultured	culture	VBN
cord-015021-pol2qm74	4565	12	with	with	IN
cord-015021-pol2qm74	4565	13	LPS	LPS	NNP
cord-015021-pol2qm74	4565	14	for	for	IN
cord-015021-pol2qm74	4565	15	24	24	CD
cord-015021-pol2qm74	4565	16	hours	hour	NNS
cord-015021-pol2qm74	4565	17	.	.	.
cord-015021-pol2qm74	4566	1	The	the	DT
cord-015021-pol2qm74	4566	2	supernatants	supernatant	NNS
cord-015021-pol2qm74	4566	3	were	be	VBD
cord-015021-pol2qm74	4566	4	collected	collect	VBN
cord-015021-pol2qm74	4566	5	and	and	CC
cord-015021-pol2qm74	4566	6	frozen	freeze	VBN
cord-015021-pol2qm74	4566	7	until	until	IN
cord-015021-pol2qm74	4566	8	assayed	assay	VBN
cord-015021-pol2qm74	4566	9	.	.	.
cord-015021-pol2qm74	4567	1	PGE	PGE	NNP
cord-015021-pol2qm74	4567	2	2	2	CD
cord-015021-pol2qm74	4567	3	was	be	VBD
cord-015021-pol2qm74	4567	4	assayed	assay	VBN
cord-015021-pol2qm74	4567	5	using	use	VBG
cord-015021-pol2qm74	4567	6	an	an	DT
cord-015021-pol2qm74	4567	7	ELISA	ELISA	NNP
cord-015021-pol2qm74	4567	8	(	(	-LRB-
cord-015021-pol2qm74	4567	9	Cayman	Cayman	NNP
cord-015021-pol2qm74	4567	10	Chemical	Chemical	NNP
cord-015021-pol2qm74	4567	11	)	)	-RRB-
cord-015021-pol2qm74	4567	12	.	.	.
cord-015021-pol2qm74	4568	1	Results	result	NNS
cord-015021-pol2qm74	4568	2	are	be	VBP
cord-015021-pol2qm74	4568	3	shown	show	VBN
cord-015021-pol2qm74	4568	4	below	below	RB
cord-015021-pol2qm74	4568	5	for	for	IN
cord-015021-pol2qm74	4568	6	the	the	DT
cord-015021-pol2qm74	4568	7	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4568	8	macrophages	macrophage	NNS
cord-015021-pol2qm74	4568	9	:	:	:
cord-015021-pol2qm74	4568	10	PGE	PGE	NNP
cord-015021-pol2qm74	4568	11	2	2	CD
cord-015021-pol2qm74	4568	12	release	release	NN
cord-015021-pol2qm74	4568	13	by	by	IN
cord-015021-pol2qm74	4568	14	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4568	15	macrophages	macrophage	NNS
cord-015021-pol2qm74	4568	16	was	be	VBD
cord-015021-pol2qm74	4568	17	significantly	significantly	RB
cord-015021-pol2qm74	4568	18	elevated	elevate	VBN
cord-015021-pol2qm74	4568	19	at	at	IN
cord-015021-pol2qm74	4568	20	24	24	CD
cord-015021-pol2qm74	4568	21	,	,	,
cord-015021-pol2qm74	4568	22	48	48	CD
cord-015021-pol2qm74	4568	23	and	and	CC
cord-015021-pol2qm74	4568	24	72	72	CD
cord-015021-pol2qm74	4568	25	hours	hour	NNS
cord-015021-pol2qm74	4568	26	over	over	IN
cord-015021-pol2qm74	4568	27	control	control	NN
cord-015021-pol2qm74	4568	28	.	.	.
cord-015021-pol2qm74	4569	1	It	-PRON-	PRP
cord-015021-pol2qm74	4569	2	was	be	VBD
cord-015021-pol2qm74	4569	3	maximal	maximal	JJ
cord-015021-pol2qm74	4569	4	at	at	IN
cord-015021-pol2qm74	4569	5	48	48	CD
cord-015021-pol2qm74	4569	6	hours	hour	NNS
cord-015021-pol2qm74	4569	7	,	,	,
cord-015021-pol2qm74	4569	8	but	but	CC
cord-015021-pol2qm74	4569	9	by	by	IN
cord-015021-pol2qm74	4569	10	72	72	CD
cord-015021-pol2qm74	4569	11	hours	hour	NNS
cord-015021-pol2qm74	4569	12	it	-PRON-	PRP
cord-015021-pol2qm74	4569	13	had	have	VBD
cord-015021-pol2qm74	4569	14	started	start	VBN
cord-015021-pol2qm74	4569	15	to	to	TO
cord-015021-pol2qm74	4569	16	decline	decline	VB
cord-015021-pol2qm74	4569	17	.	.	.
cord-015021-pol2qm74	4570	1	Splenic	Splenic	NNP
cord-015021-pol2qm74	4570	2	macrophage	macrophage	NN
cord-015021-pol2qm74	4570	3	PGE2	PGE2	NNP
cord-015021-pol2qm74	4570	4	release	release	NN
cord-015021-pol2qm74	4570	5	was	be	VBD
cord-015021-pol2qm74	4570	6	much	much	RB
cord-015021-pol2qm74	4570	7	more	more	RBR
cord-015021-pol2qm74	4570	8	variable	variable	JJ
cord-015021-pol2qm74	4570	9	.	.	.
cord-015021-pol2qm74	4571	1	(	(	-LRB-
cord-015021-pol2qm74	4571	2	Data	datum	NNS
cord-015021-pol2qm74	4571	3	not	not	RB
cord-015021-pol2qm74	4571	4	shown	show	VBN
cord-015021-pol2qm74	4571	5	.	.	.
cord-015021-pol2qm74	4571	6	)	)	-RRB-
cord-015021-pol2qm74	4572	1	There	there	EX
cord-015021-pol2qm74	4572	2	was	be	VBD
cord-015021-pol2qm74	4572	3	less	less	JJR
cord-015021-pol2qm74	4572	4	consistency	consistency	NN
cord-015021-pol2qm74	4572	5	between	between	IN
cord-015021-pol2qm74	4572	6	time	time	NN
cord-015021-pol2qm74	4572	7	points	point	NNS
cord-015021-pol2qm74	4572	8	and	and	CC
cord-015021-pol2qm74	4572	9	no	no	DT
cord-015021-pol2qm74	4572	10	clear	clear	JJ
cord-015021-pol2qm74	4572	11	trend	trend	NN
cord-015021-pol2qm74	4572	12	was	be	VBD
cord-015021-pol2qm74	4572	13	seen	see	VBN
cord-015021-pol2qm74	4572	14	.	.	.
cord-015021-pol2qm74	4573	1	In	in	IN
cord-015021-pol2qm74	4573	2	conclusion	conclusion	NN
cord-015021-pol2qm74	4573	3	,	,	,
cord-015021-pol2qm74	4573	4	PGE	PGE	NNP
cord-015021-pol2qm74	4573	5	2	2	CD
cord-015021-pol2qm74	4573	6	is	be	VBZ
cord-015021-pol2qm74	4573	7	significantly	significantly	RB
cord-015021-pol2qm74	4573	8	elevated	elevate	VBN
cord-015021-pol2qm74	4573	9	at	at	IN
cord-015021-pol2qm74	4573	10	24	24	CD
cord-015021-pol2qm74	4573	11	hours	hour	NNS
cord-015021-pol2qm74	4573	12	following	follow	VBG
cord-015021-pol2qm74	4573	13	HS	HS	NNP
cord-015021-pol2qm74	4573	14	,	,	,
cord-015021-pol2qm74	4573	15	and	and	CC
cord-015021-pol2qm74	4573	16	reaches	reach	VBZ
cord-015021-pol2qm74	4573	17	a	a	DT
cord-015021-pol2qm74	4573	18	peak	peak	NN
cord-015021-pol2qm74	4573	19	at	at	IN
cord-015021-pol2qm74	4573	20	48	48	CD
cord-015021-pol2qm74	4573	21	hours	hour	NNS
cord-015021-pol2qm74	4573	22	.	.	.
cord-015021-pol2qm74	4574	1	PGE	PGE	NNP
cord-015021-pol2qm74	4574	2	2	2	CD
cord-015021-pol2qm74	4574	3	release	release	NN
cord-015021-pol2qm74	4574	4	may	may	MD
cord-015021-pol2qm74	4574	5	be	be	VB
cord-015021-pol2qm74	4574	6	responsible	responsible	JJ
cord-015021-pol2qm74	4574	7	for	for	IN
cord-015021-pol2qm74	4574	8	the	the	DT
cord-015021-pol2qm74	4574	9	immune	immune	JJ
cord-015021-pol2qm74	4574	10	system	system	NN
cord-015021-pol2qm74	4574	11	changes	change	NNS
cord-015021-pol2qm74	4574	12	seen	see	VBN
cord-015021-pol2qm74	4574	13	in	in	IN
cord-015021-pol2qm74	4574	14	the	the	DT
cord-015021-pol2qm74	4574	15	first	first	JJ
cord-015021-pol2qm74	4574	16	few	few	JJ
cord-015021-pol2qm74	4574	17	days	day	NNS
cord-015021-pol2qm74	4574	18	following	follow	VBG
cord-015021-pol2qm74	4574	19	HS	HS	NNP
cord-015021-pol2qm74	4574	20	.	.	.
cord-015021-pol2qm74	4575	1	Splenic	splenic	JJ
cord-015021-pol2qm74	4575	2	and	and	CC
cord-015021-pol2qm74	4575	3	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	4575	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	4576	1	resPOnd	resPOnd	NNP
cord-015021-pol2qm74	4576	2	differently	differently	RB
cord-015021-pol2qm74	4576	3	in	in	IN
cord-015021-pol2qm74	4576	4	their	-PRON-	PRP$
cord-015021-pol2qm74	4576	5	release	release	NN
cord-015021-pol2qm74	4576	6	of	of	IN
cord-015021-pol2qm74	4576	7	PGE	PGE	NNP
cord-015021-pol2qm74	4576	8	2	2	CD
cord-015021-pol2qm74	4576	9	following	follow	VBG
cord-015021-pol2qm74	4576	10	HS	HS	NNP
cord-015021-pol2qm74	4576	11	;	;	:
cord-015021-pol2qm74	4576	12	which	which	WDT
cord-015021-pol2qm74	4576	13	may	may	MD
cord-015021-pol2qm74	4576	14	be	be	VB
cord-015021-pol2qm74	4576	15	due	due	JJ
cord-015021-pol2qm74	4576	16	to	to	IN
cord-015021-pol2qm74	4576	17	differences	difference	NNS
cord-015021-pol2qm74	4576	18	in	in	IN
cord-015021-pol2qm74	4576	19	their	-PRON-	PRP$
cord-015021-pol2qm74	4576	20	milieu	milieu	NN
cord-015021-pol2qm74	4576	21	.	.	.
cord-015021-pol2qm74	4577	1	There	there	EX
cord-015021-pol2qm74	4577	2	is	be	VBZ
cord-015021-pol2qm74	4577	3	an	an	DT
cord-015021-pol2qm74	4577	4	obvious	obvious	JJ
cord-015021-pol2qm74	4577	5	association	association	NN
cord-015021-pol2qm74	4577	6	between	between	IN
cord-015021-pol2qm74	4577	7	the	the	DT
cord-015021-pol2qm74	4577	8	altered	alter	VBN
cord-015021-pol2qm74	4577	9	immunocompetence	immunocompetence	NN
cord-015021-pol2qm74	4577	10	of	of	IN
cord-015021-pol2qm74	4577	11	patients	patient	NNS
cord-015021-pol2qm74	4577	12	following	follow	VBG
cord-015021-pol2qm74	4577	13	traumatic	traumatic	JJ
cord-015021-pol2qm74	4577	14	injury	injury	NN
cord-015021-pol2qm74	4577	15	of	of	IN
cord-015021-pol2qm74	4577	16	various	various	JJ
cord-015021-pol2qm74	4577	17	types	type	NNS
cord-015021-pol2qm74	4577	18	and	and	CC
cord-015021-pol2qm74	4577	19	the	the	DT
cord-015021-pol2qm74	4577	20	increased	increase	VBN
cord-015021-pol2qm74	4577	21	riskto	riskto	NN
cord-015021-pol2qm74	4577	22	develop	develop	VBP
cord-015021-pol2qm74	4577	23	complications	complication	NNS
cord-015021-pol2qm74	4577	24	.	.	.
cord-015021-pol2qm74	4578	1	The	the	DT
cord-015021-pol2qm74	4578	2	present	present	JJ
cord-015021-pol2qm74	4578	3	investigation	investigation	NN
cord-015021-pol2qm74	4578	4	was	be	VBD
cord-015021-pol2qm74	4578	5	undertaken	undertake	VBN
cord-015021-pol2qm74	4578	6	in	in	IN
cord-015021-pol2qm74	4578	7	order	order	NN
cord-015021-pol2qm74	4578	8	to	to	TO
cord-015021-pol2qm74	4578	9	analyze	analyze	VB
cord-015021-pol2qm74	4578	10	the	the	DT
cord-015021-pol2qm74	4578	11	value	value	NN
cord-015021-pol2qm74	4578	12	of	of	IN
cord-015021-pol2qm74	4578	13	both	both	CC
cord-015021-pol2qm74	4578	14	Neopterin	Neopterin	NNP
cord-015021-pol2qm74	4578	15	(	(	-LRB-
cord-015021-pol2qm74	4578	16	N	N	NNP
cord-015021-pol2qm74	4578	17	)	)	-RRB-
cord-015021-pol2qm74	4578	18	and	and	CC
cord-015021-pol2qm74	4578	19	C	C	NNP
cord-015021-pol2qm74	4578	20	-	-	HYPH
cord-015021-pol2qm74	4578	21	reactive	reactive	JJ
cord-015021-pol2qm74	4578	22	protein	protein	NN
cord-015021-pol2qm74	4578	23	(	(	-LRB-
cord-015021-pol2qm74	4578	24	CRP	CRP	NNP
cord-015021-pol2qm74	4578	25	)	)	-RRB-
cord-015021-pol2qm74	4578	26	in	in	IN
cord-015021-pol2qm74	4578	27	monitoring	monitor	VBG
cord-015021-pol2qm74	4578	28	disease	disease	NN
cord-015021-pol2qm74	4578	29	course	course	NN
cord-015021-pol2qm74	4578	30	in	in	IN
cord-015021-pol2qm74	4578	31	patients	patient	NNS
cord-015021-pol2qm74	4578	32	with	with	IN
cord-015021-pol2qm74	4578	33	multiple	multiple	JJ
cord-015021-pol2qm74	4578	34	trauma	trauma	NN
cord-015021-pol2qm74	4578	35	.	.	.
cord-015021-pol2qm74	4579	1	We	-PRON-	PRP
cord-015021-pol2qm74	4579	2	were	be	VBD
cord-015021-pol2qm74	4579	3	interested	interested	JJ
cord-015021-pol2qm74	4579	4	to	to	TO
cord-015021-pol2qm74	4579	5	compare	compare	VB
cord-015021-pol2qm74	4579	6	Nconcentrations	Nconcentrations	NNP
cord-015021-pol2qm74	4579	7	as	as	IN
cord-015021-pol2qm74	4579	8	marker	marker	NN
cord-015021-pol2qm74	4579	9	of	of	IN
cord-015021-pol2qm74	4579	10	T	t	NN
cord-015021-pol2qm74	4579	11	-	-	HYPH
cord-015021-pol2qm74	4579	12	cell	cell	NN
cord-015021-pol2qm74	4579	13	/	/	SYM
cord-015021-pol2qm74	4579	14	Macrophage	macrophage	NN
cord-015021-pol2qm74	4579	15	activation	activation	NN
cord-015021-pol2qm74	4579	16	with	with	IN
cord-015021-pol2qm74	4579	17	CRP	CRP	NNP
cord-015021-pol2qm74	4579	18	levels	level	NNS
cord-015021-pol2qm74	4579	19	as	as	IN
cord-015021-pol2qm74	4579	20	indicator	indicator	NN
cord-015021-pol2qm74	4579	21	of	of	IN
cord-015021-pol2qm74	4579	22	the	the	DT
cord-015021-pol2qm74	4579	23	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4579	24	acute	acute	JJ
cord-015021-pol2qm74	4579	25	-	-	HYPH
cord-015021-pol2qm74	4579	26	phase	phase	NN
cord-015021-pol2qm74	4579	27	response	response	NN
cord-015021-pol2qm74	4579	28	Daily	Daily	NNP
cord-015021-pol2qm74	4579	29	serum	serum	NN
cord-015021-pol2qm74	4579	30	concentrations(N	concentrations(n	NN
cord-015021-pol2qm74	4579	31	and	and	CC
cord-015021-pol2qm74	4579	32	CRP	CRP	NNP
cord-015021-pol2qm74	4579	33	)	)	-RRB-
cord-015021-pol2qm74	4579	34	were	be	VBD
cord-015021-pol2qm74	4579	35	measured	measure	VBN
cord-015021-pol2qm74	4579	36	in	in	IN
cord-015021-pol2qm74	4579	37	12	12	CD
cord-015021-pol2qm74	4579	38	patients	patient	NNS
cord-015021-pol2qm74	4579	39	(	(	-LRB-
cord-015021-pol2qm74	4579	40	9	9	CD
cord-015021-pol2qm74	4579	41	male	male	NN
cord-015021-pol2qm74	4579	42	,	,	,
cord-015021-pol2qm74	4579	43	3	3	CD
cord-015021-pol2qm74	4579	44	female	female	JJ
cord-015021-pol2qm74	4579	45	,	,	,
cord-015021-pol2qm74	4579	46	mean	mean	VB
cord-015021-pol2qm74	4579	47	age	age	NN
cord-015021-pol2qm74	4579	48	31.42	31.42	CD
cord-015021-pol2qm74	4579	49	)	)	-RRB-
cord-015021-pol2qm74	4579	50	,	,	,
cord-015021-pol2qm74	4579	51	admitted	admit	VBN
cord-015021-pol2qm74	4579	52	to	to	IN
cord-015021-pol2qm74	4579	53	our	-PRON-	PRP$
cord-015021-pol2qm74	4579	54	ICU	ICU	NNP
cord-015021-pol2qm74	4579	55	following	follow	VBG
cord-015021-pol2qm74	4579	56	serious	serious	JJ
cord-015021-pol2qm74	4579	57	trauma	trauma	NN
cord-015021-pol2qm74	4579	58	(	(	-LRB-
cord-015021-pol2qm74	4579	59	mean	mean	JJ
cord-015021-pol2qm74	4579	60	ISS=34	ISS=34	NNP
cord-015021-pol2qm74	4579	61	)	)	-RRB-
cord-015021-pol2qm74	4579	62	and	and	CC
cord-015021-pol2qm74	4579	63	in	in	IN
cord-015021-pol2qm74	4579	64	10	10	CD
cord-015021-pol2qm74	4579	65	control	control	NN
cord-015021-pol2qm74	4579	66	subjects	subject	NNS
cord-015021-pol2qm74	4579	67	.	.	.
cord-015021-pol2qm74	4580	1	The	the	DT
cord-015021-pol2qm74	4580	2	clinical	clinical	JJ
cord-015021-pol2qm74	4580	3	course	course	NN
cord-015021-pol2qm74	4580	4	of	of	IN
cord-015021-pol2qm74	4580	5	each	each	DT
cord-015021-pol2qm74	4580	6	patient	patient	NN
cord-015021-pol2qm74	4580	7	was	be	VBD
cord-015021-pol2qm74	4580	8	evaluated	evaluate	VBN
cord-015021-pol2qm74	4580	9	with	with	IN
cord-015021-pol2qm74	4580	10	APACHEII	APACHEII	NNP
cord-015021-pol2qm74	4580	11	score	score	NN
cord-015021-pol2qm74	4580	12	according	accord	VBG
cord-015021-pol2qm74	4580	13	to	to	IN
cord-015021-pol2qm74	4580	14	Knaus	Knaus	NNP
cord-015021-pol2qm74	4580	15	.	.	.
cord-015021-pol2qm74	4581	1	Mean	mean	VB
cord-015021-pol2qm74	4581	2	stay	stay	VB
cord-015021-pol2qm74	4581	3	in	in	IN
cord-015021-pol2qm74	4581	4	ICU	ICU	NNP
cord-015021-pol2qm74	4582	1	was	be	VBD
cord-015021-pol2qm74	4582	2	9.25	9.25	CD
cord-015021-pol2qm74	4582	3	(	(	-LRB-
cord-015021-pol2qm74	4582	4	range	range	NNP
cord-015021-pol2qm74	4582	5	5	5	CD
cord-015021-pol2qm74	4582	6	-	-	SYM
cord-015021-pol2qm74	4582	7	13	13	CD
cord-015021-pol2qm74	4582	8	)	)	-RRB-
cord-015021-pol2qm74	4582	9	.	.	.
cord-015021-pol2qm74	4583	1	5	5	CD
cord-015021-pol2qm74	4583	2	patients	patient	NNS
cord-015021-pol2qm74	4583	3	did	do	VBD
cord-015021-pol2qm74	4583	4	n't	not	RB
cord-015021-pol2qm74	4583	5	develop	develop	VB
cord-015021-pol2qm74	4583	6	organ	organ	NN
cord-015021-pol2qm74	4583	7	failure(NOF	failure(nof	JJ
cord-015021-pol2qm74	4583	8	-	-	HYPH
cord-015021-pol2qm74	4583	9	group	group	NN
cord-015021-pol2qm74	4583	10	)	)	-RRB-
cord-015021-pol2qm74	4583	11	,	,	,
cord-015021-pol2qm74	4583	12	4	4	CD
cord-015021-pol2qm74	4583	13	patients	patient	NNS
cord-015021-pol2qm74	4583	14	survived	survive	VBD
cord-015021-pol2qm74	4583	15	,	,	,
cord-015021-pol2qm74	4583	16	developing	develop	VBG
cord-015021-pol2qm74	4583	17	MOF	MOF	NNP
cord-015021-pol2qm74	4583	18	(	(	-LRB-
cord-015021-pol2qm74	4583	19	S	S	NNP
cord-015021-pol2qm74	4583	20	,	,	,
cord-015021-pol2qm74	4583	21	MOF	MOF	NNP
cord-015021-pol2qm74	4583	22	-	-	HYPH
cord-015021-pol2qm74	4583	23	group	group	NNP
cord-015021-pol2qm74	4583	24	)	)	-RRB-
cord-015021-pol2qm74	4583	25	,	,	,
cord-015021-pol2qm74	4583	26	3	3	CD
cord-015021-pol2qm74	4583	27	patients	patient	NNS
cord-015021-pol2qm74	4583	28	died	die	VBD
cord-015021-pol2qm74	4583	29	with	with	IN
cord-015021-pol2qm74	4583	30	MOF	MOF	NNP
cord-015021-pol2qm74	4583	31	(	(	-LRB-
cord-015021-pol2qm74	4583	32	NS	NS	NNP
cord-015021-pol2qm74	4583	33	,	,	,
cord-015021-pol2qm74	4583	34	MOFgroup	MOFgroup	NNP
cord-015021-pol2qm74	4583	35	)	)	-RRB-
cord-015021-pol2qm74	4583	36	.	.	.
cord-015021-pol2qm74	4584	1	Three	three	CD
cord-015021-pol2qm74	4584	2	patients(one	patients(one	NN
cord-015021-pol2qm74	4584	3	S	S	NNP
cord-015021-pol2qm74	4584	4	and	and	CC
cord-015021-pol2qm74	4584	5	two	two	CD
cord-015021-pol2qm74	4584	6	NS	NS	NNP
cord-015021-pol2qm74	4584	7	)	)	-RRB-
cord-015021-pol2qm74	4584	8	showed	show	VBD
cord-015021-pol2qm74	4584	9	signs	sign	NNS
cord-015021-pol2qm74	4584	10	of	of	IN
cord-015021-pol2qm74	4584	11	septicemia	septicemia	NN
cord-015021-pol2qm74	4584	12	and	and	CC
cord-015021-pol2qm74	4584	13	septic	septic	JJ
cord-015021-pol2qm74	4584	14	shock	shock	NN
cord-015021-pol2qm74	4584	15	.	.	.
cord-015021-pol2qm74	4585	1	The	the	DT
cord-015021-pol2qm74	4585	2	serum	serum	NN
cord-015021-pol2qm74	4585	3	samples	sample	NNS
cord-015021-pol2qm74	4585	4	were	be	VBD
cord-015021-pol2qm74	4585	5	measured	measure	VBN
cord-015021-pol2qm74	4585	6	for	for	IN
cord-015021-pol2qm74	4585	7	Neopterin	Neopterin	NNP
cord-015021-pol2qm74	4585	8	(	(	-LRB-
cord-015021-pol2qm74	4585	9	Immu	Immu	NNP
cord-015021-pol2qm74	4585	10	-	-	HYPH
cord-015021-pol2qm74	4585	11	Test	Test	NNP
cord-015021-pol2qm74	4585	12	-	-	HYPH
cord-015021-pol2qm74	4585	13	RIA	RIA	NNP
cord-015021-pol2qm74	4585	14	,	,	,
cord-015021-pol2qm74	4585	15	Henning	Henning	NNP
cord-015021-pol2qm74	4585	16	-	-	HYPH
cord-015021-pol2qm74	4585	17	Berlin	Berlin	NNP
cord-015021-pol2qm74	4585	18	)	)	-RRB-
cord-015021-pol2qm74	4585	19	and	and	CC
cord-015021-pol2qm74	4585	20	for	for	IN
cord-015021-pol2qm74	4585	21	CRP	CRP	NNP
cord-015021-pol2qm74	4585	22	(	(	-LRB-
cord-015021-pol2qm74	4585	23	immunoturbidimetric	immunoturbidimetric	JJ
cord-015021-pol2qm74	4585	24	method	method	NN
cord-015021-pol2qm74	4585	25	)	)	-RRB-
cord-015021-pol2qm74	4585	26	-at	-at	NFP
cord-015021-pol2qm74	4585	27	the	the	DT
cord-015021-pol2qm74	4585	28	University	University	NNP
cord-015021-pol2qm74	4585	29	Hospital	Hospital	NNP
cord-015021-pol2qm74	4585	30	for	for	IN
cord-015021-pol2qm74	4585	31	Internal	Internal	NNP
cord-015021-pol2qm74	4585	32	Medicine	Medicine	NNP
cord-015021-pol2qm74	4585	33	,	,	,
cord-015021-pol2qm74	4585	34	Innsbruck	Innsbruck	NNP
cord-015021-pol2qm74	4585	35	,	,	,
cord-015021-pol2qm74	4585	36	Austria	Austria	NNP
cord-015021-pol2qm74	4585	37	.	.	.
cord-015021-pol2qm74	4586	1	The	the	DT
cord-015021-pol2qm74	4586	2	highest	high	JJS
cord-015021-pol2qm74	4586	3	CRP	crp	NN
cord-015021-pol2qm74	4586	4	levels	level	NNS
cord-015021-pol2qm74	4586	5	were	be	VBD
cord-015021-pol2qm74	4586	6	measured	measure	VBN
cord-015021-pol2qm74	4586	7	48h	48h	NNS
cord-015021-pol2qm74	4586	8	after	after	IN
cord-015021-pol2qm74	4586	9	trauma	trauma	NN
cord-015021-pol2qm74	4586	10	,	,	,
cord-015021-pol2qm74	4586	11	but	but	CC
cord-015021-pol2qm74	4586	12	they	-PRON-	PRP
cord-015021-pol2qm74	4586	13	were	be	VBD
cord-015021-pol2qm74	4586	14	not	not	RB
cord-015021-pol2qm74	4586	15	accompanied	accompany	VBN
cord-015021-pol2qm74	4586	16	by	by	IN
cord-015021-pol2qm74	4586	17	significant	significant	JJ
cord-015021-pol2qm74	4586	18	increase	increase	NN
cord-015021-pol2qm74	4586	19	in	in	IN
cord-015021-pol2qm74	4586	20	N	n	CD
cord-015021-pol2qm74	4586	21	-	-	HYPH
cord-015021-pol2qm74	4586	22	values	value	NNS
cord-015021-pol2qm74	4586	23	.	.	.
cord-015021-pol2qm74	4587	1	We	-PRON-	PRP
cord-015021-pol2qm74	4587	2	found	find	VBD
cord-015021-pol2qm74	4587	3	significantly	significantly	RB
cord-015021-pol2qm74	4587	4	elevated	elevate	VBN
cord-015021-pol2qm74	4587	5	N	n	CD
cord-015021-pol2qm74	4587	6	-	-	HYPH
cord-015021-pol2qm74	4587	7	concentrations	concentration	NNS
cord-015021-pol2qm74	4587	8	from	from	IN
cord-015021-pol2qm74	4587	9	the	the	DT
cord-015021-pol2qm74	4587	10	days	day	NNS
cord-015021-pol2qm74	4587	11	5	5	CD
cord-015021-pol2qm74	4587	12	-	-	SYM
cord-015021-pol2qm74	4587	13	6	6	CD
cord-015021-pol2qm74	4587	14	.	.	.
cord-015021-pol2qm74	4588	1	N	N	NNP
cord-015021-pol2qm74	4588	2	and	and	CC
cord-015021-pol2qm74	4588	3	CRP	CRP	NNP
cord-015021-pol2qm74	4588	4	levels	level	NNS
cord-015021-pol2qm74	4588	5	showed	show	VBD
cord-015021-pol2qm74	4588	6	a	a	DT
cord-015021-pol2qm74	4588	7	parallel	parallel	JJ
cord-015021-pol2qm74	4588	8	release	release	NN
cord-015021-pol2qm74	4588	9	peaks	peak	NNS
cord-015021-pol2qm74	4588	10	on	on	IN
cord-015021-pol2qm74	4588	11	the	the	DT
cord-015021-pol2qm74	4588	12	days	day	NNS
cord-015021-pol2qm74	4588	13	6	6	CD
cord-015021-pol2qm74	4588	14	-	-	SYM
cord-015021-pol2qm74	4588	15	7	7	CD
cord-015021-pol2qm74	4588	16	and	and	CC
cord-015021-pol2qm74	4588	17	the	the	DT
cord-015021-pol2qm74	4588	18	values	value	NNS
cord-015021-pol2qm74	4588	19	discriminated	discriminate	VBN
cord-015021-pol2qm74	4588	20	significantly	significantly	RB
cord-015021-pol2qm74	4588	21	among	among	IN
cord-015021-pol2qm74	4588	22	the	the	DT
cord-015021-pol2qm74	4588	23	three	three	CD
cord-015021-pol2qm74	4588	24	outcome	outcome	NN
cord-015021-pol2qm74	4588	25	groups(the	groups(the	DT
cord-015021-pol2qm74	4588	26	second	second	JJ
cord-015021-pol2qm74	4588	27	CRP	CRP	NNP
cord-015021-pol2qm74	4588	28	peak	peak	NN
cord-015021-pol2qm74	4588	29	is	be	VBZ
cord-015021-pol2qm74	4588	30	lower	low	JJR
cord-015021-pol2qm74	4588	31	in	in	IN
cord-015021-pol2qm74	4588	32	comparison	comparison	NN
cord-015021-pol2qm74	4588	33	to	to	IN
cord-015021-pol2qm74	4588	34	the	the	DT
cord-015021-pol2qm74	4588	35	first	first	JJ
cord-015021-pol2qm74	4588	36	posttrauma	posttrauma	NNP
cord-015021-pol2qm74	4588	37	peak	peak	NN
cord-015021-pol2qm74	4588	38	)	)	-RRB-
cord-015021-pol2qm74	4588	39	.	.	.
cord-015021-pol2qm74	4589	1	By	by	IN
cord-015021-pol2qm74	4589	2	the	the	DT
cord-015021-pol2qm74	4589	3	NS	NS	NNP
cord-015021-pol2qm74	4589	4	-	-	HYPH
cord-015021-pol2qm74	4589	5	group	group	NN
cord-015021-pol2qm74	4589	6	we	-PRON-	PRP
cord-015021-pol2qm74	4589	7	found	find	VBD
cord-015021-pol2qm74	4589	8	constant	constant	JJ
cord-015021-pol2qm74	4589	9	and	and	CC
cord-015021-pol2qm74	4589	10	parallel	parallel	JJ
cord-015021-pol2qm74	4589	11	increasing	increase	VBG
cord-015021-pol2qm74	4589	12	CRP	CRP	NNP
cord-015021-pol2qm74	4589	13	and	and	CC
cord-015021-pol2qm74	4589	14	N	n	CD
cord-015021-pol2qm74	4589	15	levels	level	NNS
cord-015021-pol2qm74	4589	16	,	,	,
cord-015021-pol2qm74	4589	17	reaching	reach	VBG
cord-015021-pol2qm74	4589	18	extremly	extremly	RB
cord-015021-pol2qm74	4589	19	high	high	JJ
cord-015021-pol2qm74	4589	20	values	value	NNS
cord-015021-pol2qm74	4589	21	24	24	CD
cord-015021-pol2qm74	4589	22	-	-	HYPH
cord-015021-pol2qm74	4589	23	48h	48h	NNS
cord-015021-pol2qm74	4589	24	and	and	CC
cord-015021-pol2qm74	4589	25	preceding	precede	VBG
cord-015021-pol2qm74	4589	26	clinical	clinical	JJ
cord-015021-pol2qm74	4589	27	signs	sign	NNS
cord-015021-pol2qm74	4589	28	of	of	IN
cord-015021-pol2qm74	4589	29	MOF	MOF	NNP
cord-015021-pol2qm74	4589	30	and	and	CC
cord-015021-pol2qm74	4589	31	sepsis	sepsis	NN
cord-015021-pol2qm74	4589	32	.	.	.
cord-015021-pol2qm74	4590	1	The	the	DT
cord-015021-pol2qm74	4590	2	values	value	NNS
cord-015021-pol2qm74	4590	3	increased	increase	VBD
cord-015021-pol2qm74	4590	4	dramatically	dramatically	RB
cord-015021-pol2qm74	4590	5	before	before	IN
cord-015021-pol2qm74	4590	6	death	death	NN
cord-015021-pol2qm74	4590	7	.	.	.
cord-015021-pol2qm74	4591	1	The	the	DT
cord-015021-pol2qm74	4591	2	serum	serum	NN
cord-015021-pol2qm74	4591	3	levels	level	NNS
cord-015021-pol2qm74	4591	4	by	by	IN
cord-015021-pol2qm74	4591	5	all	all	DT
cord-015021-pol2qm74	4591	6	10	10	CD
cord-015021-pol2qm74	4591	7	control	control	NN
cord-015021-pol2qm74	4591	8	subjects	subject	NNS
cord-015021-pol2qm74	4591	9	were	be	VBD
cord-015021-pol2qm74	4591	10	upper	upper	JJ
cord-015021-pol2qm74	4591	11	the	the	DT
cord-015021-pol2qm74	4591	12	normal	normal	JJ
cord-015021-pol2qm74	4591	13	limit	limit	NN
cord-015021-pol2qm74	4591	14	for	for	IN
cord-015021-pol2qm74	4591	15	N	N	NNP
cord-015021-pol2qm74	4591	16	and	and	CC
cord-015021-pol2qm74	4591	17	CRP	CRP	NNP
cord-015021-pol2qm74	4591	18	..	..	.
cord-015021-pol2qm74	4592	1	The	the	DT
cord-015021-pol2qm74	4592	2	parallel	parallel	JJ
cord-015021-pol2qm74	4592	3	occured	occur	VBD
cord-015021-pol2qm74	4592	4	peak	peak	NN
cord-015021-pol2qm74	4592	5	changes	change	NNS
cord-015021-pol2qm74	4592	6	in	in	IN
cord-015021-pol2qm74	4592	7	N	N	NNP
cord-015021-pol2qm74	4592	8	and	and	CC
cord-015021-pol2qm74	4592	9	CRP	CRP	NNP
cord-015021-pol2qm74	4592	10	concentrations	concentration	NNS
cord-015021-pol2qm74	4592	11	showed	show	VBD
cord-015021-pol2qm74	4592	12	a	a	DT
cord-015021-pol2qm74	4592	13	significant	significant	JJ
cord-015021-pol2qm74	4592	14	correlation	correlation	NN
cord-015021-pol2qm74	4592	15	with	with	IN
cord-015021-pol2qm74	4592	16	clinical	clinical	JJ
cord-015021-pol2qm74	4592	17	status	status	NN
cord-015021-pol2qm74	4592	18	,	,	,
cord-015021-pol2qm74	4592	19	using	use	VBG
cord-015021-pol2qm74	4592	20	a	a	DT
cord-015021-pol2qm74	4592	21	disease	disease	NN
cord-015021-pol2qm74	4592	22	activity	activity	NN
cord-015021-pol2qm74	4592	23	score	score	NN
cord-015021-pol2qm74	4592	24	(	(	-LRB-
cord-015021-pol2qm74	4592	25	APAC	APAC	NNP
cord-015021-pol2qm74	4592	26	H	H	NNP
cord-015021-pol2qm74	4592	27	Eli	Eli	NNP
cord-015021-pol2qm74	4592	28	)	)	-RRB-
cord-015021-pol2qm74	4592	29	.	.	.
cord-015021-pol2qm74	4593	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	4593	2	findings	finding	NNS
cord-015021-pol2qm74	4593	3	suggest	suggest	VBP
cord-015021-pol2qm74	4593	4	that	that	IN
cord-015021-pol2qm74	4593	5	both	both	DT
cord-015021-pol2qm74	4593	6	-	-	HYPH
cord-015021-pol2qm74	4593	7	cellular	cellular	JJ
cord-015021-pol2qm74	4593	8	and	and	CC
cord-015021-pol2qm74	4593	9	humoral	humoral	JJ
cord-015021-pol2qm74	4593	10	mediated	mediate	VBN
cord-015021-pol2qm74	4593	11	immune	immune	JJ
cord-015021-pol2qm74	4593	12	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4593	13	are	be	VBP
cord-015021-pol2qm74	4593	14	activated	activate	VBN
cord-015021-pol2qm74	4593	15	after	after	IN
cord-015021-pol2qm74	4593	16	multiple	multiple	JJ
cord-015021-pol2qm74	4593	17	trauma	trauma	NN
cord-015021-pol2qm74	4593	18	and	and	CC
cord-015021-pol2qm74	4593	19	that	that	IN
cord-015021-pol2qm74	4593	20	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	4593	21	determination	determination	NN
cord-015021-pol2qm74	4593	22	of	of	IN
cord-015021-pol2qm74	4593	23	N	N	NNP
cord-015021-pol2qm74	4593	24	-	-	HYPH
cord-015021-pol2qm74	4593	25	CRP	CRP	NNP
cord-015021-pol2qm74	4593	26	may	may	MD
cord-015021-pol2qm74	4593	27	be	be	VB
cord-015021-pol2qm74	4593	28	of	of	IN
cord-015021-pol2qm74	4593	29	advantage	advantage	NN
cord-015021-pol2qm74	4593	30	as	as	IN
cord-015021-pol2qm74	4593	31	diagnostic	diagnostic	JJ
cord-015021-pol2qm74	4593	32	and	and	CC
cord-015021-pol2qm74	4593	33	prognostic	prognostic	JJ
cord-015021-pol2qm74	4593	34	parameter	parameter	NN
cord-015021-pol2qm74	4593	35	in	in	IN
cord-015021-pol2qm74	4593	36	polytrauma	polytrauma	NN
cord-015021-pol2qm74	4593	37	-	-	HYPH
cord-015021-pol2qm74	4593	38	patient	patient	JJ
cord-015021-pol2qm74	4593	39	monitoring	monitoring	NN
cord-015021-pol2qm74	4593	40	panel	panel	NN
cord-015021-pol2qm74	4593	41	.	.	.
cord-015021-pol2qm74	4594	1	It	-PRON-	PRP
cord-015021-pol2qm74	4594	2	is	be	VBZ
cord-015021-pol2qm74	4594	3	apparent	apparent	JJ
cord-015021-pol2qm74	4594	4	,	,	,
cord-015021-pol2qm74	4594	5	that	that	DT
cord-015021-pol2qm74	4594	6	measurement	measurement	NN
cord-015021-pol2qm74	4594	7	of	of	IN
cord-015021-pol2qm74	4594	8	very	very	RB
cord-015021-pol2qm74	4594	9	high	high	JJ
cord-015021-pol2qm74	4594	10	levels	level	NNS
cord-015021-pol2qm74	4594	11	may	may	MD
cord-015021-pol2qm74	4594	12	be	be	VB
cord-015021-pol2qm74	4594	13	of	of	IN
cord-015021-pol2qm74	4594	14	value	value	NN
cord-015021-pol2qm74	4594	15	as	as	IN
cord-015021-pol2qm74	4594	16	a	a	DT
cord-015021-pol2qm74	4594	17	srong	srong	JJ
cord-015021-pol2qm74	4594	18	indicator	indicator	NN
cord-015021-pol2qm74	4594	19	in	in	IN
cord-015021-pol2qm74	4594	20	developing	developing	NN
cord-015021-pol2qm74	4594	21	of	of	IN
cord-015021-pol2qm74	4594	22	MOF	MOF	NNP
cord-015021-pol2qm74	4594	23	or	or	CC
cord-015021-pol2qm74	4594	24	septic	septic	JJ
cord-015021-pol2qm74	4594	25	complications	complication	NNS
cord-015021-pol2qm74	4594	26	and	and	CC
cord-015021-pol2qm74	4594	27	thus	thus	RB
cord-015021-pol2qm74	4594	28	offer	offer	VBP
cord-015021-pol2qm74	4594	29	the	the	DT
cord-015021-pol2qm74	4594	30	possibility	possibility	NN
cord-015021-pol2qm74	4594	31	for	for	IN
cord-015021-pol2qm74	4594	32	earlier	early	JJR
cord-015021-pol2qm74	4594	33	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	4594	34	intervention	intervention	NN
cord-015021-pol2qm74	4594	35	.	.	.
cord-015021-pol2qm74	4595	1	The	the	DT
cord-015021-pol2qm74	4595	2	modification	modification	NN
cord-015021-pol2qm74	4595	3	of	of	IN
cord-015021-pol2qm74	4595	4	T	t	NN
cord-015021-pol2qm74	4595	5	-	-	HYPH
cord-015021-pol2qm74	4595	6	cell	cell	NN
cord-015021-pol2qm74	4595	7	/	/	SYM
cord-015021-pol2qm74	4595	8	Macrophage	macrophage	NN
cord-015021-pol2qm74	4595	9	and	and	CC
cord-015021-pol2qm74	4595	10	acute	acute	JJ
cord-015021-pol2qm74	4595	11	-	-	HYPH
cord-015021-pol2qm74	4595	12	phase	phase	NN
cord-015021-pol2qm74	4595	13	responses	response	NNS
cord-015021-pol2qm74	4595	14	may	may	MD
cord-015021-pol2qm74	4595	15	be	be	VB
cord-015021-pol2qm74	4595	16	potentially	potentially	RB
cord-015021-pol2qm74	4595	17	useful	useful	JJ
cord-015021-pol2qm74	4595	18	in	in	IN
cord-015021-pol2qm74	4595	19	the	the	DT
cord-015021-pol2qm74	4595	20	treatment	treatment	NN
cord-015021-pol2qm74	4595	21	of	of	IN
cord-015021-pol2qm74	4595	22	ICU	ICU	NNP
cord-015021-pol2qm74	4595	23	patients	patient	NNS
cord-015021-pol2qm74	4595	24	,	,	,
cord-015021-pol2qm74	4595	25	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	4595	26	after	after	IN
cord-015021-pol2qm74	4595	27	severe	severe	JJ
cord-015021-pol2qm74	4595	28	trauma	trauma	NN
cord-015021-pol2qm74	4595	29	,	,	,
cord-015021-pol2qm74	4595	30	and	and	CC
cord-015021-pol2qm74	4595	31	suggest	suggest	VBP
cord-015021-pol2qm74	4595	32	that	that	IN
cord-015021-pol2qm74	4595	33	N	N	NNP
cord-015021-pol2qm74	4595	34	-	-	HYPH
cord-015021-pol2qm74	4595	35	CRP	CRP	NNP
cord-015021-pol2qm74	4595	36	may	may	MD
cord-015021-pol2qm74	4595	37	be	be	VB
cord-015021-pol2qm74	4595	38	relevant	relevant	JJ
cord-015021-pol2qm74	4595	39	indicator	indicator	NN
cord-015021-pol2qm74	4595	40	for	for	IN
cord-015021-pol2qm74	4595	41	testing	test	VBG
cord-015021-pol2qm74	4595	42	experimental	experimental	JJ
cord-015021-pol2qm74	4595	43	immunomodulating	immunomodulating	JJ
cord-015021-pol2qm74	4595	44	therapies	therapy	NNS
cord-015021-pol2qm74	4595	45	.	.	.
cord-015021-pol2qm74	4596	1	Although	although	IN
cord-015021-pol2qm74	4596	2	several	several	JJ
cord-015021-pol2qm74	4596	3	in	in	IN
cord-015021-pol2qm74	4596	4	vitro	vitro	FW
cord-015021-pol2qm74	4596	5	studies	study	NNS
cord-015021-pol2qm74	4596	6	suggested	suggest	VBD
cord-015021-pol2qm74	4596	7	the	the	DT
cord-015021-pol2qm74	4596	8	catalytic	catalytic	JJ
cord-015021-pol2qm74	4596	9	action	action	NN
cord-015021-pol2qm74	4596	10	of	of	IN
cord-015021-pol2qm74	4596	11	iron	iron	NN
cord-015021-pol2qm74	4596	12	in	in	IN
cord-015021-pol2qm74	4596	13	oxygen	oxygen	NN
cord-015021-pol2qm74	4596	14	free	free	JJ
cord-015021-pol2qm74	4596	15	radical	radical	JJ
cord-015021-pol2qm74	4596	16	generation	generation	NN
cord-015021-pol2qm74	4596	17	,	,	,
cord-015021-pol2qm74	4596	18	few	few	JJ
cord-015021-pol2qm74	4596	19	data	datum	NNS
cord-015021-pol2qm74	4596	20	are	be	VBP
cord-015021-pol2qm74	4596	21	available	available	JJ
cord-015021-pol2qm74	4596	22	concerning	concern	VBG
cord-015021-pol2qm74	4596	23	iron	iron	NN
cord-015021-pol2qm74	4596	24	-	-	HYPH
cord-015021-pol2qm74	4596	25	metabolism	metabolism	NN
cord-015021-pol2qm74	4596	26	following	follow	VBG
cord-015021-pol2qm74	4596	27	ischemia	ischemia	NN
cord-015021-pol2qm74	4596	28	-	-	HYPH
cord-015021-pol2qm74	4596	29	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4596	30	injury	injury	NN
cord-015021-pol2qm74	4596	31	and	and	CC
cord-015021-pol2qm74	4596	32	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4596	33	in	in	IN
cord-015021-pol2qm74	4596	34	vivo	vivo	NN
cord-015021-pol2qm74	4596	35	.	.	.
cord-015021-pol2qm74	4597	1	Aim	aim	VB
cord-015021-pol2qm74	4597	2	of	of	IN
cord-015021-pol2qm74	4597	3	the	the	DT
cord-015021-pol2qm74	4597	4	present	present	JJ
cord-015021-pol2qm74	4597	5	studies	study	NNS
cord-015021-pol2qm74	4597	6	was	be	VBD
cord-015021-pol2qm74	4597	7	to	to	TO
cord-015021-pol2qm74	4597	8	evaluate	evaluate	VB
cord-015021-pol2qm74	4597	9	iron	iron	NN
cord-015021-pol2qm74	4597	10	metabolism	metabolism	NN
cord-015021-pol2qm74	4597	11	following	follow	VBG
cord-015021-pol2qm74	4597	12	mild	mild	JJ
cord-015021-pol2qm74	4597	13	and	and	CC
cord-015021-pol2qm74	4597	14	severe	severe	JJ
cord-015021-pol2qm74	4597	15	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4597	16	in	in	IN
cord-015021-pol2qm74	4597	17	the	the	DT
cord-015021-pol2qm74	4597	18	presence	presence	NN
cord-015021-pol2qm74	4597	19	and	and	CC
cord-015021-pol2qm74	4597	20	absence	absence	NN
cord-015021-pol2qm74	4597	21	of	of	IN
cord-015021-pol2qm74	4597	22	intraperituneal	intraperituneal	NN
cord-015021-pol2qm74	4597	23	hematoma	hematoma	NN
cord-015021-pol2qm74	4597	24	.	.	.
cord-015021-pol2qm74	4598	1	Methods	method	NNS
cord-015021-pol2qm74	4598	2	.	.	.
cord-015021-pol2qm74	4599	1	Male	Male	NNP
cord-015021-pol2qm74	4599	2	Lewis	Lewis	NNP
cord-015021-pol2qm74	4599	3	rats	rat	NNS
cord-015021-pol2qm74	4599	4	(	(	-LRB-
cord-015021-pol2qm74	4599	5	300	300	CD
cord-015021-pol2qm74	4599	6	g	g	NN
cord-015021-pol2qm74	4599	7	)	)	-RRB-
cord-015021-pol2qm74	4599	8	divided	divide	VBD
cord-015021-pol2qm74	4599	9	in	in	IN
cord-015021-pol2qm74	4599	10	4	4	CD
cord-015021-pol2qm74	4599	11	groups	group	NNS
cord-015021-pol2qm74	4599	12	(	(	-LRB-
cord-015021-pol2qm74	4599	13	observation	observation	NN
cord-015021-pol2qm74	4599	14	time	time	NN
cord-015021-pol2qm74	4599	15	120	120	CD
cord-015021-pol2qm74	4599	16	hrs	hrs	NN
cord-015021-pol2qm74	4599	17	)	)	-RRB-
cord-015021-pol2qm74	4599	18	:	:	:
cord-015021-pol2qm74	4600	1	A	a	DT
cord-015021-pol2qm74	4600	2	:	:	:
cord-015021-pol2qm74	4600	3	mild	mild	JJ
cord-015021-pol2qm74	4600	4	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4600	5	by	by	IN
cord-015021-pol2qm74	4600	6	sequential	sequential	JJ
cord-015021-pol2qm74	4600	7	blood	blood	NN
cord-015021-pol2qm74	4600	8	sampling	sampling	NN
cord-015021-pol2qm74	4600	9	(	(	-LRB-
cord-015021-pol2qm74	4600	10	0.9	0.9	CD
cord-015021-pol2qm74	4600	11	ml	ml	NN
cord-015021-pol2qm74	4600	12	each)(0	each)(0	NNP
cord-015021-pol2qm74	4600	13	,	,	,
cord-015021-pol2qm74	4600	14	2	2	CD
cord-015021-pol2qm74	4600	15	,	,	,
cord-015021-pol2qm74	4600	16	4	4	CD
cord-015021-pol2qm74	4600	17	,	,	,
cord-015021-pol2qm74	4600	18	6	6	CD
cord-015021-pol2qm74	4600	19	,	,	,
cord-015021-pol2qm74	4600	20	24	24	CD
cord-015021-pol2qm74	4600	21	,	,	,
cord-015021-pol2qm74	4600	22	48	48	CD
cord-015021-pol2qm74	4600	23	,	,	,
cord-015021-pol2qm74	4600	24	72	72	CD
cord-015021-pol2qm74	4600	25	,	,	,
cord-015021-pol2qm74	4600	26	96	96	CD
cord-015021-pol2qm74	4600	27	,	,	,
cord-015021-pol2qm74	4600	28	120	120	CD
cord-015021-pol2qm74	4600	29	hrs	hrs	NN
cord-015021-pol2qm74	4600	30	)	)	-RRB-
cord-015021-pol2qm74	4600	31	.	.	.
cord-015021-pol2qm74	4601	1	B	b	NN
cord-015021-pol2qm74	4601	2	:	:	:
cord-015021-pol2qm74	4602	1	A	a	DT
cord-015021-pol2qm74	4602	2	with	with	IN
cord-015021-pol2qm74	4602	3	hemoperitoneum	hemoperitoneum	NNP
cord-015021-pol2qm74	4602	4	(	(	-LRB-
cord-015021-pol2qm74	4602	5	HP)(2	HP)(2	NNP
cord-015021-pol2qm74	4602	6	ml/100	ml/100	NNS
cord-015021-pol2qm74	4602	7	g	g	NNP
cord-015021-pol2qm74	4602	8	)	)	-RRB-
cord-015021-pol2qm74	4602	9	,	,	,
cord-015021-pol2qm74	4602	10	C	c	NN
cord-015021-pol2qm74	4602	11	:	:	:
cord-015021-pol2qm74	4602	12	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	4602	13	shock	shock	NN
cord-015021-pol2qm74	4602	14	:	:	:
cord-015021-pol2qm74	4602	15	blood	blood	NN
cord-015021-pol2qm74	4602	16	withdrawal	withdrawal	NN
cord-015021-pol2qm74	4602	17	of	of	IN
cord-015021-pol2qm74	4602	18	3	3	CD
cord-015021-pol2qm74	4602	19	ml/100	ml/100	NN
cord-015021-pol2qm74	4602	20	g	g	NN
cord-015021-pol2qm74	4602	21	over	over	IN
cord-015021-pol2qm74	4602	22	30	30	CD
cord-015021-pol2qm74	4602	23	min	min	NN
cord-015021-pol2qm74	4602	24	and	and	CC
cord-015021-pol2qm74	4602	25	resuscitation	resuscitation	NN
cord-015021-pol2qm74	4602	26	with	with	IN
cord-015021-pol2qm74	4602	27	Ringer	Ringer	NNP
cord-015021-pol2qm74	4602	28	's	's	POS
cord-015021-pol2qm74	4602	29	lactate	lactate	NN
cord-015021-pol2qm74	4602	30	(	(	-LRB-
cord-015021-pol2qm74	4602	31	2	2	CD
cord-015021-pol2qm74	4602	32	x	x	SYM
cord-015021-pol2qm74	4602	33	shed	shed	JJ
cord-015021-pol2qm74	4602	34	blood	blood	NN
cord-015021-pol2qm74	4602	35	)	)	-RRB-
cord-015021-pol2qm74	4602	36	and	and	CC
cord-015021-pol2qm74	4602	37	isogenic	isogenic	JJ
cord-015021-pol2qm74	4602	38	donor	donor	NN
cord-015021-pol2qm74	4602	39	blood	blood	NN
cord-015021-pol2qm74	4602	40	;	;	.
cord-015021-pol2qm74	4603	1	D	D	NNP
cord-015021-pol2qm74	4603	2	:	:	:
cord-015021-pol2qm74	4603	3	C	C	NNP
cord-015021-pol2qm74	4603	4	with	with	IN
cord-015021-pol2qm74	4603	5	HP	HP	NNP
cord-015021-pol2qm74	4603	6	.	.	.
cord-015021-pol2qm74	4604	1	Parameters	parameter	NNS
cord-015021-pol2qm74	4604	2	:	:	:
cord-015021-pol2qm74	4604	3	serum	serum	NN
cord-015021-pol2qm74	4604	4	iron	iron	NN
cord-015021-pol2qm74	4604	5	(	(	-LRB-
cord-015021-pol2qm74	4604	6	[	[	-LRB-
cord-015021-pol2qm74	4604	7	g	g	NNP
cord-015021-pol2qm74	4604	8	/	/	SYM
cord-015021-pol2qm74	4604	9	dl	dl	NNP
cord-015021-pol2qm74	4604	10	]	]	-RRB-
cord-015021-pol2qm74	4604	11	,	,	,
cord-015021-pol2qm74	4604	12	ferrozin	ferrozin	JJ
cord-015021-pol2qm74	4604	13	-	-	HYPH
cord-015021-pol2qm74	4604	14	method	method	NN
cord-015021-pol2qm74	4604	15	)	)	-RRB-
cord-015021-pol2qm74	4604	16	;	;	:
cord-015021-pol2qm74	4604	17	59Fe	59fe	CD
cord-015021-pol2qm74	4604	18	labeling	labeling	NN
cord-015021-pol2qm74	4604	19	of	of	IN
cord-015021-pol2qm74	4604	20	erythrocytas	erythrocytas	NNP
cord-015021-pol2qm74	4604	21	(	(	-LRB-
cord-015021-pol2qm74	4604	22	application	application	NN
cord-015021-pol2qm74	4604	23	of	of	IN
cord-015021-pol2qm74	4604	24	1	1	CD
cord-015021-pol2qm74	4604	25	Ci	Ci	NNP
cord-015021-pol2qm74	4604	26	59Fe	59Fe	NNP
cord-015021-pol2qm74	4604	27	i.a	i.a	NNP
cord-015021-pol2qm74	4604	28	.	.	NNP
cord-015021-pol2qm74	4604	29	into	into	IN
cord-015021-pol2qm74	4604	30	a	a	DT
cord-015021-pol2qm74	4604	31	donor	donor	NN
cord-015021-pol2qm74	4604	32	rat	rat	NN
cord-015021-pol2qm74	4604	33	,	,	,
cord-015021-pol2qm74	4604	34	5	5	CD
cord-015021-pol2qm74	4604	35	days	day	NNS
cord-015021-pol2qm74	4604	36	later	later	RB
cord-015021-pol2qm74	4604	37	bleeding	bleed	VBG
cord-015021-pol2qm74	4604	38	of	of	IN
cord-015021-pol2qm74	4604	39	the	the	DT
cord-015021-pol2qm74	4604	40	rat	rat	NN
cord-015021-pol2qm74	4604	41	and	and	CC
cord-015021-pol2qm74	4604	42	injection	injection	NN
cord-015021-pol2qm74	4604	43	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	4604	44	in	in	IN
cord-015021-pol2qm74	4604	45	experimental	experimental	JJ
cord-015021-pol2qm74	4604	46	rat	rat	NN
cord-015021-pol2qm74	4604	47	;	;	:
cord-015021-pol2qm74	4604	48	plasma	plasma	NN
cord-015021-pol2qm74	4604	49	transferrin	transferrin	NN
cord-015021-pol2qm74	4604	50	(	(	-LRB-
cord-015021-pol2qm74	4604	51	[	[	-LRB-
cord-015021-pol2qm74	4604	52	g	g	NN
cord-015021-pol2qm74	4604	53	/	/	SYM
cord-015021-pol2qm74	4604	54	ml	ml	NN
cord-015021-pol2qm74	4604	55	]	]	-RRB-
cord-015021-pol2qm74	4604	56	,	,	,
cord-015021-pol2qm74	4604	57	RIA	RIA	NNP
cord-015021-pol2qm74	4604	58	)	)	-RRB-
cord-015021-pol2qm74	4604	59	.	.	.
cord-015021-pol2qm74	4605	1	T	t	NN
cord-015021-pol2qm74	4605	2	-	-	HYPH
cord-015021-pol2qm74	4605	3	tests	test	NNS
cord-015021-pol2qm74	4605	4	and	and	CC
cord-015021-pol2qm74	4605	5	Mann	Mann	NNP
cord-015021-pol2qm74	4605	6	Whitney	Whitney	NNP
cord-015021-pol2qm74	4605	7	.	.	.
cord-015021-pol2qm74	4606	1	Data	datum	NNS
cord-015021-pol2qm74	4606	2	are	be	VBP
cord-015021-pol2qm74	4606	3	expressed	express	VBN
cord-015021-pol2qm74	4606	4	as	as	IN
cord-015021-pol2qm74	4606	5	mean	mean	JJ
cord-015021-pol2qm74	4606	6	+	+	CC
cord-015021-pol2qm74	4606	7	SEM	sem	NN
cord-015021-pol2qm74	4606	8	.	.	.
cord-015021-pol2qm74	4607	1	Results	result	NNS
cord-015021-pol2qm74	4607	2	.	.	.
cord-015021-pol2qm74	4608	1	Compared	compare	VBN
cord-015021-pol2qm74	4608	2	to	to	IN
cord-015021-pol2qm74	4608	3	baseline	baseline	NN
cord-015021-pol2qm74	4608	4	,	,	,
cord-015021-pol2qm74	4608	5	mild	mild	JJ
cord-015021-pol2qm74	4608	6	and	and	CC
cord-015021-pol2qm74	4608	7	severe	severe	JJ
cord-015021-pol2qm74	4608	8	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4608	9	caused	cause	VBD
cord-015021-pol2qm74	4608	10	a	a	DT
cord-015021-pol2qm74	4608	11	significant	significant	JJ
cord-015021-pol2qm74	4608	12	increase	increase	NN
cord-015021-pol2qm74	4608	13	in	in	IN
cord-015021-pol2qm74	4608	14	serum	serum	NN
cord-015021-pol2qm74	4608	15	iron	iron	NN
cord-015021-pol2qm74	4608	16	at	at	IN
cord-015021-pol2qm74	4608	17	24	24	CD
cord-015021-pol2qm74	4608	18	and	and	CC
cord-015021-pol2qm74	4608	19	48	48	CD
cord-015021-pol2qm74	4608	20	hrs	hrs	NN
cord-015021-pol2qm74	4608	21	,	,	,
cord-015021-pol2qm74	4608	22	respectively	respectively	RB
cord-015021-pol2qm74	4608	23	(	(	-LRB-
cord-015021-pol2qm74	4608	24	212	212	CD
cord-015021-pol2qm74	4608	25	+	+	SYM
cord-015021-pol2qm74	4608	26	30	30	CD
cord-015021-pol2qm74	4608	27	vs.	vs.	NN
cord-015021-pol2qm74	4608	28	248	248	CD
cord-015021-pol2qm74	4608	29	+	+	SYM
cord-015021-pol2qm74	4608	30	35	35	CD
cord-015021-pol2qm74	4608	31	;	;	:
cord-015021-pol2qm74	4608	32	185+_28	185+_28	CD
cord-015021-pol2qm74	4608	33	vs.	vs.	IN
cord-015021-pol2qm74	4608	34	255+_22	255+_22	CD
cord-015021-pol2qm74	4608	35	)	)	-RRB-
cord-015021-pol2qm74	4608	36	.	.	.
cord-015021-pol2qm74	4609	1	HP	HP	NNP
cord-015021-pol2qm74	4609	2	reduced	reduce	VBD
cord-015021-pol2qm74	4609	3	this	this	DT
cord-015021-pol2qm74	4609	4	increase	increase	NN
cord-015021-pol2qm74	4609	5	(	(	-LRB-
cord-015021-pol2qm74	4609	6	209+_17	209+_17	CD
cord-015021-pol2qm74	4609	7	vs.	vs.	FW
cord-015021-pol2qm74	4609	8	177	177	CD
cord-015021-pol2qm74	4609	9	+	+	SYM
cord-015021-pol2qm74	4609	10	21	21	CD
cord-015021-pol2qm74	4609	11	;	;	:
cord-015021-pol2qm74	4609	12	194	194	CD
cord-015021-pol2qm74	4609	13	+	+	SYM
cord-015021-pol2qm74	4609	14	25	25	CD
cord-015021-pol2qm74	4609	15	vs.	vs.	NN
cord-015021-pol2qm74	4609	16	197	197	CD
cord-015021-pol2qm74	4609	17	+	+	SYM
cord-015021-pol2qm74	4609	18	-48	-48	NNP
cord-015021-pol2qm74	4609	19	,	,	,
cord-015021-pol2qm74	4609	20	p<.05	p<.05	NNP
cord-015021-pol2qm74	4609	21	)	)	-RRB-
cord-015021-pol2qm74	4609	22	.	.	.
cord-015021-pol2qm74	4610	1	I	-PRON-	PRP
cord-015021-pol2qm74	4610	2	-	-	HYPH
cord-015021-pol2qm74	4610	3	IP	IP	NNP
cord-015021-pol2qm74	4610	4	significantly	significantly	RB
cord-015021-pol2qm74	4610	5	increased	increase	VBD
cord-015021-pol2qm74	4610	6	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	4610	7	between	between	IN
cord-015021-pol2qm74	4610	8	24	24	CD
cord-015021-pol2qm74	4610	9	to	to	TO
cord-015021-pol2qm74	4610	10	96	96	CD
cord-015021-pol2qm74	4610	11	hrs	hrs	NN
cord-015021-pol2qm74	4610	12	in	in	IN
cord-015021-pol2qm74	4610	13	mild	mild	JJ
cord-015021-pol2qm74	4610	14	(	(	-LRB-
cord-015021-pol2qm74	4610	15	12.1+_.8	12.1+_.8	JJ
cord-015021-pol2qm74	4610	16	vs.	vs.	FW
cord-015021-pol2qm74	4610	17	14.2+.7	14.2+.7	CD
cord-015021-pol2qm74	4610	18	)	)	-RRB-
cord-015021-pol2qm74	4610	19	and	and	CC
cord-015021-pol2qm74	4610	20	severe	severe	JJ
cord-015021-pol2qm74	4610	21	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4610	22	(	(	-LRB-
cord-015021-pol2qm74	4610	23	10.3+.6	10.3+.6	CD
cord-015021-pol2qm74	4610	24	vs.	vs.	IN
cord-015021-pol2qm74	4610	25	13.1+.6	13.1+.6	CD
cord-015021-pol2qm74	4610	26	)	)	-RRB-
cord-015021-pol2qm74	4610	27	.	.	.
cord-015021-pol2qm74	4611	1	In	in	IN
cord-015021-pol2qm74	4611	2	mild	mild	JJ
cord-015021-pol2qm74	4611	3	and	and	CC
cord-015021-pol2qm74	4611	4	severe	severe	JJ
cord-015021-pol2qm74	4611	5	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4611	6	comparable	comparable	JJ
cord-015021-pol2qm74	4611	7	maximal	maximal	JJ
cord-015021-pol2qm74	4611	8	resorption	resorption	NN
cord-015021-pol2qm74	4611	9	(	(	-LRB-
cord-015021-pol2qm74	4611	10	59Fe	59fe	CD
cord-015021-pol2qm74	4611	11	labeled	label	VBN
cord-015021-pol2qm74	4611	12	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	4611	13	in	in	IN
cord-015021-pol2qm74	4611	14	circulating	circulate	VBG
cord-015021-pol2qm74	4611	15	blood	blood	NN
cord-015021-pol2qm74	4611	16	)	)	-RRB-
cord-015021-pol2qm74	4611	17	of	of	IN
cord-015021-pol2qm74	4611	18	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	4611	19	hematoma	hematoma	NN
cord-015021-pol2qm74	4611	20	occured	occur	VBD
cord-015021-pol2qm74	4611	21	at	at	IN
cord-015021-pol2qm74	4611	22	24	24	CD
cord-015021-pol2qm74	4611	23	hrs	hrs	NN
cord-015021-pol2qm74	4611	24	(	(	-LRB-
cord-015021-pol2qm74	4611	25	mild	mild	JJ
cord-015021-pol2qm74	4611	26	:	:	:
cord-015021-pol2qm74	4611	27	318+_71	318+_71	CD
cord-015021-pol2qm74	4611	28	vs.	vs.	IN
cord-015021-pol2qm74	4611	29	severe	severe	JJ
cord-015021-pol2qm74	4611	30	:	:	:
cord-015021-pol2qm74	4612	1	364	364	CD
cord-015021-pol2qm74	4612	2	+	+	SYM
cord-015021-pol2qm74	4612	3	-114	-114	NNP
cord-015021-pol2qm74	4612	4	counts	count	NNS
cord-015021-pol2qm74	4612	5	/	/	SYM
cord-015021-pol2qm74	4612	6	rain	rain	NN
cord-015021-pol2qm74	4612	7	)	)	-RRB-
cord-015021-pol2qm74	4612	8	.	.	.
cord-015021-pol2qm74	4613	1	HP	HP	NNP
cord-015021-pol2qm74	4613	2	increased	increase	VBD
cord-015021-pol2qm74	4613	3	survival	survival	NN
cord-015021-pol2qm74	4613	4	-	-	HYPH
cord-015021-pol2qm74	4613	5	rate	rate	NN
cord-015021-pol2qm74	4613	6	following	follow	VBG
cord-015021-pol2qm74	4613	7	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	4613	8	shock	shock	NN
cord-015021-pol2qm74	4613	9	(	(	-LRB-
cord-015021-pol2qm74	4613	10	no	no	DT
cord-015021-pol2qm74	4613	11	HP	hp	NN
cord-015021-pol2qm74	4613	12	:	:	:
cord-015021-pol2qm74	4613	13	10/17	10/17	CD
cord-015021-pol2qm74	4613	14	;	;	:
cord-015021-pol2qm74	4613	15	HP	HP	NNP
cord-015021-pol2qm74	4613	16	:	:	:
cord-015021-pol2qm74	4613	17	10/13	10/13	CD
cord-015021-pol2qm74	4613	18	)	)	-RRB-
cord-015021-pol2qm74	4613	19	.	.	.
cord-015021-pol2qm74	4614	1	In	in	IN
cord-015021-pol2qm74	4614	2	mild	mild	JJ
cord-015021-pol2qm74	4614	3	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4614	4	no	no	DT
cord-015021-pol2qm74	4614	5	alterations	alteration	NNS
cord-015021-pol2qm74	4614	6	of	of	IN
cord-015021-pol2qm74	4614	7	plasma	plasma	NN
cord-015021-pol2qm74	4614	8	transferrin	transferrin	NN
cord-015021-pol2qm74	4614	9	concentrations	concentration	NNS
cord-015021-pol2qm74	4614	10	.	.	.
cord-015021-pol2qm74	4615	1	In	in	IN
cord-015021-pol2qm74	4615	2	shock	shock	NN
cord-015021-pol2qm74	4615	3	group	group	NN
cord-015021-pol2qm74	4615	4	without	without	IN
cord-015021-pol2qm74	4615	5	HP	HP	NNP
cord-015021-pol2qm74	4615	6	,	,	,
cord-015021-pol2qm74	4615	7	there	there	EX
cord-015021-pol2qm74	4615	8	was	be	VBD
cord-015021-pol2qm74	4615	9	at	at	IN
cord-015021-pol2qm74	4615	10	96	96	CD
cord-015021-pol2qm74	4615	11	hrs	hrs	NN
cord-015021-pol2qm74	4615	12	a	a	DT
cord-015021-pol2qm74	4615	13	significant	significant	JJ
cord-015021-pol2qm74	4615	14	higher	high	JJR
cord-015021-pol2qm74	4615	15	transferrin	transferrin	NN
cord-015021-pol2qm74	4615	16	level	level	NN
cord-015021-pol2qm74	4615	17	than	than	IN
cord-015021-pol2qm74	4615	18	with	with	IN
cord-015021-pol2qm74	4615	19	HP	HP	NNP
cord-015021-pol2qm74	4615	20	alone	alone	JJ
cord-015021-pol2qm74	4616	1	(	(	-LRB-
cord-015021-pol2qm74	4616	2	3.2+_.5	3.2+_.5	NNP
cord-015021-pol2qm74	4616	3	vs.	vs.	NNP
cord-015021-pol2qm74	4616	4	2.23	2.23	CD
cord-015021-pol2qm74	4616	5	+	+	CD
cord-015021-pol2qm74	4616	6	.2	.2	CD
cord-015021-pol2qm74	4616	7	)	)	-RRB-
cord-015021-pol2qm74	4616	8	.	.	.
cord-015021-pol2qm74	4617	1	In	in	IN
cord-015021-pol2qm74	4617	2	conclusion	conclusion	NN
cord-015021-pol2qm74	4617	3	,	,	,
cord-015021-pol2qm74	4617	4	hemoperitoneum	hemoperitoneum	NNP
cord-015021-pol2qm74	4617	5	with	with	IN
cord-015021-pol2qm74	4617	6	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	4617	7	prevents	prevent	VBZ
cord-015021-pol2qm74	4617	8	increase	increase	NN
cord-015021-pol2qm74	4617	9	in	in	IN
cord-015021-pol2qm74	4617	10	plasma	plasma	NN
cord-015021-pol2qm74	4617	11	iron	iron	NN
cord-015021-pol2qm74	4617	12	levels	level	NNS
cord-015021-pol2qm74	4617	13	by	by	IN
cord-015021-pol2qm74	4617	14	increasing	increase	VBG
cord-015021-pol2qm74	4617	15	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	4617	16	through	through	IN
cord-015021-pol2qm74	4617	17	resorption	resorption	NN
cord-015021-pol2qm74	4617	18	of	of	IN
cord-015021-pol2qm74	4617	19	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	4617	20	and	and	CC
cord-015021-pol2qm74	4617	21	thereby	thereby	RB
cord-015021-pol2qm74	4617	22	suppressing	suppress	VBG
cord-015021-pol2qm74	4617	23	iron	iron	NN
cord-015021-pol2qm74	4617	24	mobilization	mobilization	NN
cord-015021-pol2qm74	4617	25	from	from	IN
cord-015021-pol2qm74	4617	26	endogenous	endogenous	JJ
cord-015021-pol2qm74	4617	27	iron	iron	NN
cord-015021-pol2qm74	4617	28	resources	resource	NNS
cord-015021-pol2qm74	4617	29	,	,	,
cord-015021-pol2qm74	4617	30	e.g.	e.g.	RB
cord-015021-pol2qm74	4617	31	liver	liver	NN
cord-015021-pol2qm74	4617	32	.	.	.
cord-015021-pol2qm74	4618	1	This	this	DT
cord-015021-pol2qm74	4618	2	suggests	suggest	VBZ
cord-015021-pol2qm74	4618	3	that	that	IN
cord-015021-pol2qm74	4618	4	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	4618	5	hematoma	hematoma	NN
cord-015021-pol2qm74	4618	6	not	not	RB
cord-015021-pol2qm74	4618	7	necessarily	necessarily	RB
cord-015021-pol2qm74	4618	8	promotes	promote	VBZ
cord-015021-pol2qm74	4618	9	iron	iron	NN
cord-015021-pol2qm74	4618	10	-	-	HYPH
cord-015021-pol2qm74	4618	11	mediated	mediate	VBN
cord-015021-pol2qm74	4618	12	oxygen	oxygen	NN
cord-015021-pol2qm74	4618	13	free	free	JJ
cord-015021-pol2qm74	4618	14	radical	radical	JJ
cord-015021-pol2qm74	4618	15	production	production	NN
cord-015021-pol2qm74	4618	16	,	,	,
cord-015021-pol2qm74	4618	17	especially	especially	RB
cord-015021-pol2qm74	4618	18	since	since	IN
cord-015021-pol2qm74	4618	19	survival	survival	NN
cord-015021-pol2qm74	4618	20	in	in	IN
cord-015021-pol2qm74	4618	21	these	these	DT
cord-015021-pol2qm74	4618	22	groups	group	NNS
cord-015021-pol2qm74	4618	23	was	be	VBD
cord-015021-pol2qm74	4618	24	improved	improve	VBN
cord-015021-pol2qm74	4618	25	.	.	.
cord-015021-pol2qm74	4619	1	Increased	increase	VBN
cord-015021-pol2qm74	4619	2	transfarrin	transfarrin	NN
cord-015021-pol2qm74	4619	3	levels	level	NNS
cord-015021-pol2qm74	4619	4	in	in	IN
cord-015021-pol2qm74	4619	5	group	group	NN
cord-015021-pol2qm74	4619	6	C	c	NN
cord-015021-pol2qm74	4619	7	at	at	IN
cord-015021-pol2qm74	4619	8	the	the	DT
cord-015021-pol2qm74	4619	9	end	end	NN
cord-015021-pol2qm74	4619	10	of	of	IN
cord-015021-pol2qm74	4619	11	the	the	DT
cord-015021-pol2qm74	4619	12	experiment	experiment	NN
cord-015021-pol2qm74	4619	13	suggest	suggest	VBP
cord-015021-pol2qm74	4619	14	increased	increase	VBN
cord-015021-pol2qm74	4619	15	iron	iron	NN
cord-015021-pol2qm74	4619	16	turnover	turnover	NN
cord-015021-pol2qm74	4619	17	which	which	WDT
cord-015021-pol2qm74	4619	18	was	be	VBD
cord-015021-pol2qm74	4619	19	not	not	RB
cord-015021-pol2qm74	4619	20	observed	observe	VBN
cord-015021-pol2qm74	4619	21	in	in	IN
cord-015021-pol2qm74	4619	22	shock	shock	NN
cord-015021-pol2qm74	4619	23	groups	group	NNS
cord-015021-pol2qm74	4619	24	associated	associate	VBN
cord-015021-pol2qm74	4619	25	with	with	IN
cord-015021-pol2qm74	4619	26	hemoperitoneum	hemoperitoneum	NNP
cord-015021-pol2qm74	4619	27	.	.	.
cord-015021-pol2qm74	4620	1	Primary	primary	JJ
cord-015021-pol2qm74	4620	2	immune	immune	JJ
cord-015021-pol2qm74	4620	3	response	response	NN
cord-015021-pol2qm74	4620	4	to	to	IN
cord-015021-pol2qm74	4620	5	thymus	thymus	NN
cord-015021-pol2qm74	4620	6	-	-	HYPH
cord-015021-pol2qm74	4620	7	dependent	dependent	JJ
cord-015021-pol2qm74	4620	8	(	(	-LRB-
cord-015021-pol2qm74	4620	9	SRBC	SRBC	NNP
cord-015021-pol2qm74	4620	10	)	)	-RRB-
cord-015021-pol2qm74	4620	11	and	and	CC
cord-015021-pol2qm74	4620	12	thymus	thymus	NN
cord-015021-pol2qm74	4620	13	-	-	HYPH
cord-015021-pol2qm74	4620	14	independent	independent	JJ
cord-015021-pol2qm74	4621	1	(	(	-LRB-
cord-015021-pol2qm74	4621	2	Vi	Vi	NNP
cord-015021-pol2qm74	4621	3	-	-	HYPH
cord-015021-pol2qm74	4621	4	polysaccharide	polysaccharide	NN
cord-015021-pol2qm74	4621	5	)	)	-RRB-
cord-015021-pol2qm74	4621	6	antigens	antigen	NNS
cord-015021-pol2qm74	4621	7	was	be	VBD
cord-015021-pol2qm74	4621	8	determined	determine	VBN
cord-015021-pol2qm74	4621	9	during	during	IN
cord-015021-pol2qm74	4621	10	30	30	CD
cord-015021-pol2qm74	4621	11	days	day	NNS
cord-015021-pol2qm74	4621	12	after	after	IN
cord-015021-pol2qm74	4621	13	CCT	CCT	NNP
cord-015021-pol2qm74	4621	14	.	.	.
cord-015021-pol2qm74	4622	1	Antigenic	antigenic	JJ
cord-015021-pol2qm74	4622	2	challenge	challenge	NN
cord-015021-pol2qm74	4622	3	was	be	VBD
cord-015021-pol2qm74	4622	4	made	make	VBN
cord-015021-pol2qm74	4622	5	on	on	IN
cord-015021-pol2qm74	4622	6	day	day	NN
cord-015021-pol2qm74	4622	7	i	i	PRP
cord-015021-pol2qm74	4622	8	,	,	,
cord-015021-pol2qm74	4622	9	5	5	CD
cord-015021-pol2qm74	4622	10	,	,	,
cord-015021-pol2qm74	4622	11	15	15	CD
cord-015021-pol2qm74	4622	12	or	or	CC
cord-015021-pol2qm74	4622	13	30	30	CD
cord-015021-pol2qm74	4622	14	.	.	.
cord-015021-pol2qm74	4623	1	Number	number	NN
cord-015021-pol2qm74	4623	2	of	of	IN
cord-015021-pol2qm74	4623	3	spleen	spleen	NN
cord-015021-pol2qm74	4623	4	plaque	plaque	NN
cord-015021-pol2qm74	4623	5	forming	form	VBG
cord-015021-pol2qm74	4623	6	cells	cell	NNS
cord-015021-pol2qm74	4623	7	(	(	-LRB-
cord-015021-pol2qm74	4623	8	PFC	PFC	NNP
cord-015021-pol2qm74	4623	9	)	)	-RRB-
cord-015021-pol2qm74	4623	10	and	and	CC
cord-015021-pol2qm74	4623	11	serum	serum	NN
cord-015021-pol2qm74	4623	12	haemagglutinin	haemagglutinin	NNP
cord-015021-pol2qm74	4623	13	(	(	-LRB-
cord-015021-pol2qm74	4623	14	HA	HA	NNP
cord-015021-pol2qm74	4623	15	)	)	-RRB-
cord-015021-pol2qm74	4623	16	titre	titre	NN
cord-015021-pol2qm74	4623	17	were	be	VBD
cord-015021-pol2qm74	4623	18	studied	study	VBN
cord-015021-pol2qm74	4623	19	on	on	IN
cord-015021-pol2qm74	4623	20	day	day	NN
cord-015021-pol2qm74	4623	21	5	5	CD
cord-015021-pol2qm74	4623	22	after	after	IN
cord-015021-pol2qm74	4623	23	immunization	immunization	NN
cord-015021-pol2qm74	4623	24	.	.	.
cord-015021-pol2qm74	4624	1	CCT	CCT	NNP
cord-015021-pol2qm74	4624	2	stimulated	stimulate	VBD
cord-015021-pol2qm74	4624	3	immune	immune	JJ
cord-015021-pol2qm74	4624	4	response	response	NN
cord-015021-pol2qm74	4624	5	to	to	IN
cord-015021-pol2qm74	4624	6	T	t	NN
cord-015021-pol2qm74	4624	7	-	-	HYPH
cord-015021-pol2qm74	4624	8	dependent	dependent	JJ
cord-015021-pol2qm74	4624	9	,	,	,
cord-015021-pol2qm74	4624	10	but	but	CC
cord-015021-pol2qm74	4624	11	not	not	RB
cord-015021-pol2qm74	4624	12	to	to	IN
cord-015021-pol2qm74	4624	13	T	T	NNP
cord-015021-pol2qm74	4624	14	-	-	HYPH
cord-015021-pol2qm74	4624	15	independent	independent	JJ
cord-015021-pol2qm74	4624	16	antigen	antigen	NN
cord-015021-pol2qm74	4624	17	.	.	.
cord-015021-pol2qm74	4625	1	Enhanced	enhanced	JJ
cord-015021-pol2qm74	4625	2	response	response	NN
cord-015021-pol2qm74	4625	3	was	be	VBD
cord-015021-pol2qm74	4625	4	noted	note	VBN
cord-015021-pol2qm74	4625	5	when	when	WRB
cord-015021-pol2qm74	4625	6	SRBS	SRBS	NNP
cord-015021-pol2qm74	4625	7	were	be	VBD
cord-015021-pol2qm74	4625	8	given	give	VBN
cord-015021-pol2qm74	4625	9	in	in	IN
cord-015021-pol2qm74	4625	10	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	4625	11	day	day	NN
cord-015021-pol2qm74	4625	12	i	i	PRP
cord-015021-pol2qm74	4625	13	,	,	,
cord-015021-pol2qm74	4625	14	it	-PRON-	PRP
cord-015021-pol2qm74	4625	15	was	be	VBD
cord-015021-pol2qm74	4625	16	higher	high	JJR
cord-015021-pol2qm74	4625	17	than	than	IN
cord-015021-pol2qm74	4625	18	preceding	precede	VBG
cord-015021-pol2qm74	4625	19	one	one	CD
cord-015021-pol2qm74	4625	20	after	after	IN
cord-015021-pol2qm74	4625	21	injection	injection	NN
cord-015021-pol2qm74	4625	22	on	on	IN
cord-015021-pol2qm74	4625	23	day	day	NN
cord-015021-pol2qm74	4625	24	5	5	CD
cord-015021-pol2qm74	4625	25	and	and	CC
cord-015021-pol2qm74	4625	26	reached	reach	VBD
cord-015021-pol2qm74	4625	27	a	a	DT
cord-015021-pol2qm74	4625	28	maximum	maximum	NN
cord-015021-pol2qm74	4625	29	when	when	WRB
cord-015021-pol2qm74	4625	30	antigen	antigen	NN
cord-015021-pol2qm74	4625	31	was	be	VBD
cord-015021-pol2qm74	4625	32	presented	present	VBN
cord-015021-pol2qm74	4625	33	on	on	IN
cord-015021-pol2qm74	4625	34	day	day	NN
cord-015021-pol2qm74	4625	35	15	15	CD
cord-015021-pol2qm74	4625	36	after	after	IN
cord-015021-pol2qm74	4625	37	trauma	trauma	NN
cord-015021-pol2qm74	4626	1	(	(	-LRB-
cord-015021-pol2qm74	4626	2	PFC	PFC	NNP
cord-015021-pol2qm74	4626	3	number	number	NN
cord-015021-pol2qm74	4626	4	2.4	2.4	CD
cord-015021-pol2qm74	4626	5	times	time	NNS
cord-015021-pol2qm74	4626	6	exceeded	exceed	VBD
cord-015021-pol2qm74	4626	7	the	the	DT
cord-015021-pol2qm74	4626	8	level	level	NN
cord-015021-pol2qm74	4626	9	of	of	IN
cord-015021-pol2qm74	4626	10	immunized	immunize	VBN
cord-015021-pol2qm74	4626	11	,	,	,
cord-015021-pol2qm74	4626	12	but	but	CC
cord-015021-pol2qm74	4626	13	nontraumatized	nontraumatized	JJ
cord-015021-pol2qm74	4626	14	rats	rat	NNS
cord-015021-pol2qm74	4626	15	)	)	-RRB-
cord-015021-pol2qm74	4626	16	.	.	.
cord-015021-pol2qm74	4627	1	The	the	DT
cord-015021-pol2qm74	4627	2	rise	rise	NN
cord-015021-pol2qm74	4627	3	of	of	IN
cord-015021-pol2qm74	4627	4	PFC	PFC	NNP
cord-015021-pol2qm74	4627	5	number	number	NN
cord-015021-pol2qm74	4627	6	in	in	IN
cord-015021-pol2qm74	4627	7	spleen	spleen	NN
cord-015021-pol2qm74	4627	8	correlated	correlate	VBN
cord-015021-pol2qm74	4627	9	with	with	IN
cord-015021-pol2qm74	4627	10	increased	increase	VBN
cord-015021-pol2qm74	4627	11	HA	HA	NNP
cord-015021-pol2qm74	4627	12	level	level	NN
cord-015021-pol2qm74	4627	13	.	.	.
cord-015021-pol2qm74	4628	1	Thymectomy	Thymectomy	NNP
cord-015021-pol2qm74	4628	2	had	have	VBD
cord-015021-pol2qm74	4628	3	been	be	VBN
cord-015021-pol2qm74	4628	4	performed	perform	VBN
cord-015021-pol2qm74	4628	5	30	30	CD
cord-015021-pol2qm74	4628	6	days	day	NNS
cord-015021-pol2qm74	4628	7	before	before	IN
cord-015021-pol2qm74	4628	8	CCT	CCT	NNP
cord-015021-pol2qm74	4628	9	completely	completely	RB
cord-015021-pol2qm74	4628	10	abolished	abolish	VBD
cord-015021-pol2qm74	4628	11	posttraumatio	posttraumatio	JJ
cord-015021-pol2qm74	4628	12	stimulation	stimulation	NN
cord-015021-pol2qm74	4628	13	of	of	IN
cord-015021-pol2qm74	4628	14	immune	immune	JJ
cord-015021-pol2qm74	4628	15	response	response	NN
cord-015021-pol2qm74	4628	16	to	to	IN
cord-015021-pol2qm74	4628	17	T	t	NN
cord-015021-pol2qm74	4628	18	-	-	HYPH
cord-015021-pol2qm74	4628	19	dependent	dependent	JJ
cord-015021-pol2qm74	4628	20	antigen	antigen	NN
cord-015021-pol2qm74	4628	21	.	.	.
cord-015021-pol2qm74	4629	1	Standard	standard	JJ
cord-015021-pol2qm74	4629	2	thoracotomy	thoracotomy	NN
cord-015021-pol2qm74	4629	3	also	also	RB
cord-015021-pol2qm74	4629	4	enhanced	enhance	VBD
cord-015021-pol2qm74	4629	5	humoral	humoral	JJ
cord-015021-pol2qm74	4629	6	response	response	NN
cord-015021-pol2qm74	4629	7	when	when	WRB
cord-015021-pol2qm74	4629	8	SRBC	SRBC	NNP
cord-015021-pol2qm74	4629	9	were	be	VBD
cord-015021-pol2qm74	4629	10	administered	administer	VBN
cord-015021-pol2qm74	4629	11	on	on	IN
cord-015021-pol2qm74	4629	12	day	day	NN
cord-015021-pol2qm74	4629	13	15	15	CD
cord-015021-pol2qm74	4629	14	after	after	IN
cord-015021-pol2qm74	4629	15	the	the	DT
cord-015021-pol2qm74	4629	16	operation	operation	NN
cord-015021-pol2qm74	4629	17	.	.	.
cord-015021-pol2qm74	4630	1	Thymus	thymus	NN
cord-015021-pol2qm74	4630	2	trauma	trauma	NN
cord-015021-pol2qm74	4630	3	modeled	model	VBN
cord-015021-pol2qm74	4630	4	by	by	IN
cord-015021-pol2qm74	4630	5	pincett	pincett	NN
cord-015021-pol2qm74	4630	6	squeezing	squeezing	NN
cord-015021-pol2qm74	4630	7	of	of	IN
cord-015021-pol2qm74	4630	8	its	-PRON-	PRP$
cord-015021-pol2qm74	4630	9	right	right	JJ
cord-015021-pol2qm74	4630	10	lobe	lobe	NN
cord-015021-pol2qm74	4630	11	and	and	CC
cord-015021-pol2qm74	4630	12	performed	perform	VBD
cord-015021-pol2qm74	4630	13	at	at	IN
cord-015021-pol2qm74	4630	14	the	the	DT
cord-015021-pol2qm74	4630	15	same	same	JJ
cord-015021-pol2qm74	4630	16	time	time	NN
cord-015021-pol2qm74	4630	17	with	with	IN
cord-015021-pol2qm74	4630	18	thoracotomy	thoracotomy	NN
cord-015021-pol2qm74	4630	19	fully	fully	RB
cord-015021-pol2qm74	4630	20	abrogated	abrogate	VBD
cord-015021-pol2qm74	4630	21	as	as	RB
cord-015021-pol2qm74	4630	22	well	well	RB
cord-015021-pol2qm74	4630	23	as	as	IN
cord-015021-pol2qm74	4630	24	thymectomy	thymectomy	NN
cord-015021-pol2qm74	4630	25	stimulation	stimulation	NN
cord-015021-pol2qm74	4630	26	of	of	IN
cord-015021-pol2qm74	4630	27	immune	immune	JJ
cord-015021-pol2qm74	4630	28	reaction	reaction	NN
cord-015021-pol2qm74	4630	29	.	.	.
cord-015021-pol2qm74	4631	1	Thus	thus	RB
cord-015021-pol2qm74	4631	2	,	,	,
cord-015021-pol2qm74	4631	3	different	different	JJ
cord-015021-pol2qm74	4631	4	experimental	experimental	JJ
cord-015021-pol2qm74	4631	5	chest	chest	NN
cord-015021-pol2qm74	4631	6	traumas	trauma	NNS
cord-015021-pol2qm74	4631	7	are	be	VBP
cord-015021-pol2qm74	4631	8	able	able	JJ
cord-015021-pol2qm74	4631	9	to	to	TO
cord-015021-pol2qm74	4631	10	increase	increase	VB
cord-015021-pol2qm74	4631	11	antibody	antibody	NN
cord-015021-pol2qm74	4631	12	production	production	NN
cord-015021-pol2qm74	4631	13	via	via	IN
cord-015021-pol2qm74	4631	14	thymus	thymus	NN
cord-015021-pol2qm74	4631	15	-	-	HYPH
cord-015021-pol2qm74	4631	16	dependent	dependent	JJ
cord-015021-pol2qm74	4631	17	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4631	18	.	.	.
cord-015021-pol2qm74	4632	1	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	4632	2	is	be	VBZ
cord-015021-pol2qm74	4632	3	a	a	DT
cord-015021-pol2qm74	4632	4	21	21	CD
cord-015021-pol2qm74	4632	5	amino	amino	NN
cord-015021-pol2qm74	4632	6	acid	acid	NN
cord-015021-pol2qm74	4632	7	peptide	peptide	NN
cord-015021-pol2qm74	4632	8	produced	produce	VBN
cord-015021-pol2qm74	4632	9	by	by	IN
cord-015021-pol2qm74	4632	10	ischemic	ischemic	JJ
cord-015021-pol2qm74	4632	11	or	or	CC
cord-015021-pol2qm74	4632	12	injured	injure	VBN
cord-015021-pol2qm74	4632	13	endothelial	endothelial	JJ
cord-015021-pol2qm74	4632	14	cells	cell	NNS
cord-015021-pol2qm74	4632	15	.	.	.
cord-015021-pol2qm74	4633	1	In	in	IN
cord-015021-pol2qm74	4633	2	vitro	vitro	FW
cord-015021-pol2qm74	4633	3	and	and	CC
cord-015021-pol2qm74	4633	4	in	in	IN
cord-015021-pol2qm74	4633	5	animal	animal	NN
cord-015021-pol2qm74	4633	6	studies	study	NNS
cord-015021-pol2qm74	4633	7	,	,	,
cord-015021-pol2qm74	4633	8	ET	ET	NNP
cord-015021-pol2qm74	4633	9	is	be	VBZ
cord-015021-pol2qm74	4633	10	also	also	RB
cord-015021-pol2qm74	4633	11	a	a	DT
cord-015021-pol2qm74	4633	12	potent	potent	JJ
cord-015021-pol2qm74	4633	13	constrictor	constrictor	NN
cord-015021-pol2qm74	4633	14	for	for	IN
cord-015021-pol2qm74	4633	15	renal	renal	JJ
cord-015021-pol2qm74	4633	16	mesangial	mesangial	JJ
cord-015021-pol2qm74	4633	17	and	and	CC
cord-015021-pol2qm74	4633	18	coronary	coronary	JJ
cord-015021-pol2qm74	4633	19	vessels	vessel	NNS
cord-015021-pol2qm74	4633	20	,	,	,
cord-015021-pol2qm74	4633	21	a	a	DT
cord-015021-pol2qm74	4633	22	negative	negative	JJ
cord-015021-pol2qm74	4633	23	cardiac	cardiac	JJ
cord-015021-pol2qm74	4633	24	inotrope	inotrope	NN
cord-015021-pol2qm74	4633	25	and	and	CC
cord-015021-pol2qm74	4633	26	an	an	DT
cord-015021-pol2qm74	4633	27	endocrine	endocrine	JJ
cord-015021-pol2qm74	4633	28	regulator	regulator	NN
cord-015021-pol2qm74	4633	29	.	.	.
cord-015021-pol2qm74	4634	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	4634	2	lab	lab	NN
cord-015021-pol2qm74	4634	3	has	have	VBZ
cord-015021-pol2qm74	4634	4	shown	show	VBN
cord-015021-pol2qm74	4634	5	that	that	IN
cord-015021-pol2qm74	4634	6	ET	ET	NNP
cord-015021-pol2qm74	4634	7	is	be	VBZ
cord-015021-pol2qm74	4634	8	an	an	DT
cord-015021-pol2qm74	4634	9	agonist	agonist	NN
cord-015021-pol2qm74	4634	10	for	for	IN
cord-015021-pol2qm74	4634	11	monocyte	monocyte	JJ
cord-015021-pol2qm74	4634	12	production	production	NN
cord-015021-pol2qm74	4634	13	of	of	IN
cord-015021-pol2qm74	4634	14	interleukins	interleukin	NNS
cord-015021-pol2qm74	4634	15	i	i	PRP
cord-015021-pol2qm74	4634	16	,	,	,
cord-015021-pol2qm74	4634	17	6	6	CD
cord-015021-pol2qm74	4634	18	&	&	CC
cord-015021-pol2qm74	4634	19	8	8	CD
cord-015021-pol2qm74	4634	20	,	,	,
cord-015021-pol2qm74	4634	21	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	4634	22	E	e	NN
cord-015021-pol2qm74	4634	23	2	2	CD
cord-015021-pol2qm74	4634	24	(	(	-LRB-
cord-015021-pol2qm74	4634	25	PGE2	PGE2	NNP
cord-015021-pol2qm74	4634	26	)	)	-RRB-
cord-015021-pol2qm74	4634	27	,	,	,
cord-015021-pol2qm74	4634	28	and	and	CC
cord-015021-pol2qm74	4634	29	substances	substance	NNS
cord-015021-pol2qm74	4634	30	which	which	WDT
cord-015021-pol2qm74	4634	31	trigger	trigger	VBP
cord-015021-pol2qm74	4634	32	superoxide	superoxide	NN
cord-015021-pol2qm74	4634	33	production	production	NN
cord-015021-pol2qm74	4634	34	.	.	.
cord-015021-pol2qm74	4635	1	Systemic	systemic	JJ
cord-015021-pol2qm74	4635	2	ET	ET	NNP
cord-015021-pol2qm74	4635	3	levels	level	NNS
cord-015021-pol2qm74	4635	4	increase	increase	NN
cord-015021-pol2qm74	4635	5	in	in	IN
cord-015021-pol2qm74	4635	6	hypoperfused	hypoperfused	JJ
cord-015021-pol2qm74	4635	7	and	and	CC
cord-015021-pol2qm74	4635	8	septic	septic	JJ
cord-015021-pol2qm74	4635	9	patients	patient	NNS
cord-015021-pol2qm74	4635	10	,	,	,
cord-015021-pol2qm74	4635	11	and	and	CC
cord-015021-pol2qm74	4635	12	ET	ET	NNP
cord-015021-pol2qm74	4635	13	may	may	MD
cord-015021-pol2qm74	4635	14	be	be	VB
cord-015021-pol2qm74	4635	15	yet	yet	RB
cord-015021-pol2qm74	4635	16	another	another	DT
cord-015021-pol2qm74	4635	17	important	important	JJ
cord-015021-pol2qm74	4635	18	cytokine	cytokine	NN
cord-015021-pol2qm74	4635	19	in	in	IN
cord-015021-pol2qm74	4635	20	critical	critical	JJ
cord-015021-pol2qm74	4635	21	illness	illness	NN
cord-015021-pol2qm74	4635	22	.	.	.
cord-015021-pol2qm74	4636	1	But	but	CC
cord-015021-pol2qm74	4636	2	while	while	IN
cord-015021-pol2qm74	4636	3	ET	ET	NNP
cord-015021-pol2qm74	4636	4	has	have	VBZ
cord-015021-pol2qm74	4636	5	been	be	VBN
cord-015021-pol2qm74	4636	6	shown	show	VBN
cord-015021-pol2qm74	4636	7	to	to	TO
cord-015021-pol2qm74	4636	8	be	be	VB
cord-015021-pol2qm74	4636	9	a	a	DT
cord-015021-pol2qm74	4636	10	potent	potent	JJ
cord-015021-pol2qm74	4636	11	vasoconstrictor	vasoconstrictor	NN
cord-015021-pol2qm74	4636	12	in	in	IN
cord-015021-pol2qm74	4636	13	healthy	healthy	JJ
cord-015021-pol2qm74	4636	14	dogs	dog	NNS
cord-015021-pol2qm74	4636	15	,	,	,
cord-015021-pol2qm74	4636	16	systemic	systemic	JJ
cord-015021-pol2qm74	4636	17	vascular	vascular	JJ
cord-015021-pol2qm74	4636	18	resistance	resistance	NN
cord-015021-pol2qm74	4636	19	does	do	VBZ
cord-015021-pol2qm74	4636	20	not	not	RB
cord-015021-pol2qm74	4636	21	increase	increase	VB
cord-015021-pol2qm74	4636	22	in	in	IN
cord-015021-pol2qm74	4636	23	critically	critically	RB
cord-015021-pol2qm74	4636	24	ill	ill	JJ
cord-015021-pol2qm74	4636	25	patients	patient	NNS
cord-015021-pol2qm74	4636	26	with	with	IN
cord-015021-pol2qm74	4636	27	high	high	JJ
cord-015021-pol2qm74	4636	28	ET	ET	NNP
cord-015021-pol2qm74	4636	29	levels	level	NNS
cord-015021-pol2qm74	4636	30	.	.	.
cord-015021-pol2qm74	4637	1	(	(	-LRB-
cord-015021-pol2qm74	4637	2	We	-PRON-	PRP
cord-015021-pol2qm74	4637	3	hypothesize	hypothesize	VBP
cord-015021-pol2qm74	4637	4	that	that	IN
cord-015021-pol2qm74	4637	5	this	this	DT
cord-015021-pol2qm74	4637	6	might	may	MD
cord-015021-pol2qm74	4637	7	be	be	VB
cord-015021-pol2qm74	4637	8	due	due	JJ
cord-015021-pol2qm74	4637	9	to	to	IN
cord-015021-pol2qm74	4637	10	PGEz	PGEz	NNS
cord-015021-pol2qm74	4637	11	-	-	HYPH
cord-015021-pol2qm74	4637	12	mediated	mediate	VBN
cord-015021-pol2qm74	4637	13	vasodilation	vasodilation	NN
cord-015021-pol2qm74	4637	14	predominating	predominate	VBG
cord-015021-pol2qm74	4637	15	over	over	IN
cord-015021-pol2qm74	4637	16	ET	et	NN
cord-015021-pol2qm74	4637	17	-	-	HYPH
cord-015021-pol2qm74	4637	18	mediated	mediate	VBN
cord-015021-pol2qm74	4637	19	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	4637	20	.	.	.
cord-015021-pol2qm74	4637	21	)	)	-RRB-
cord-015021-pol2qm74	4638	1	We	-PRON-	PRP
cord-015021-pol2qm74	4638	2	next	next	RB
cord-015021-pol2qm74	4638	3	asked	ask	VBD
cord-015021-pol2qm74	4638	4	what	what	WP
cord-015021-pol2qm74	4638	5	happened	happen	VBD
cord-015021-pol2qm74	4638	6	to	to	IN
cord-015021-pol2qm74	4638	7	systemic	systemic	JJ
cord-015021-pol2qm74	4638	8	ET	ET	NNP
cord-015021-pol2qm74	4638	9	levels	level	NNS
cord-015021-pol2qm74	4638	10	in	in	IN
cord-015021-pol2qm74	4638	11	patients	patient	NNS
cord-015021-pol2qm74	4638	12	with	with	IN
cord-015021-pol2qm74	4638	13	major	major	JJ
cord-015021-pol2qm74	4638	14	burns	burn	NNS
cord-015021-pol2qm74	4638	15	(	(	-LRB-
cord-015021-pol2qm74	4638	16	>	>	NFP
cord-015021-pol2qm74	4638	17	20	20	CD
cord-015021-pol2qm74	4638	18	%	%	NN
cord-015021-pol2qm74	4638	19	.	.	.
cord-015021-pol2qm74	4638	20	)	)	-RRB-
cord-015021-pol2qm74	4639	1	Ten	ten	CD
cord-015021-pol2qm74	4639	2	hemodynamically	hemodynamically	RB
cord-015021-pol2qm74	4639	3	stable	stable	JJ
cord-015021-pol2qm74	4639	4	patients	patient	NNS
cord-015021-pol2qm74	4639	5	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	4639	6	by	by	IN
cord-015021-pol2qm74	4639	7	a	a	DT
cord-015021-pol2qm74	4639	8	modified	modify	VBN
cord-015021-pol2qm74	4639	9	Parkland	Parkland	NNP
cord-015021-pol2qm74	4639	10	formula	formula	NN
cord-015021-pol2qm74	4639	11	to	to	IN
cord-015021-pol2qm74	4639	12	a	a	DT
cord-015021-pol2qm74	4639	13	urine	urine	NN
cord-015021-pol2qm74	4639	14	output	output	NN
cord-015021-pol2qm74	4639	15	>	>	XX
cord-015021-pol2qm74	4639	16	30	30	CD
cord-015021-pol2qm74	4639	17	cc	cc	NN
cord-015021-pol2qm74	4639	18	's	's	NN
cord-015021-pol2qm74	4639	19	per	per	IN
cord-015021-pol2qm74	4639	20	hour	hour	NN
cord-015021-pol2qm74	4639	21	had	have	VBD
cord-015021-pol2qm74	4639	22	ET	ET	NNP
cord-015021-pol2qm74	4639	23	levels	level	NNS
cord-015021-pol2qm74	4639	24	drawn	draw	VBN
cord-015021-pol2qm74	4639	25	on	on	IN
cord-015021-pol2qm74	4639	26	admission	admission	NN
cord-015021-pol2qm74	4639	27	,	,	,
cord-015021-pol2qm74	4639	28	at	at	IN
cord-015021-pol2qm74	4639	29	i	i	PRP
cord-015021-pol2qm74	4639	30	,	,	,
cord-015021-pol2qm74	4639	31	6	6	CD
cord-015021-pol2qm74	4639	32	12	12	CD
cord-015021-pol2qm74	4639	33	,	,	,
cord-015021-pol2qm74	4639	34	24	24	CD
cord-015021-pol2qm74	4639	35	,	,	,
cord-015021-pol2qm74	4639	36	and	and	CC
cord-015021-pol2qm74	4639	37	48	48	CD
cord-015021-pol2qm74	4639	38	hrs	hrs	NN
cord-015021-pol2qm74	4639	39	.	.	.
cord-015021-pol2qm74	4640	1	ET	ET	NNP
cord-015021-pol2qm74	4640	2	levels	level	NNS
cord-015021-pol2qm74	4640	3	were	be	VBD
cord-015021-pol2qm74	4640	4	measured	measure	VBN
cord-015021-pol2qm74	4640	5	by	by	IN
cord-015021-pol2qm74	4640	6	radioimmunoassay	radioimmunoassay	JJ
cord-015021-pol2qm74	4640	7	.	.	.
cord-015021-pol2qm74	4641	1	Mean	mean	JJ
cord-015021-pol2qm74	4641	2	levels	level	NNS
cord-015021-pol2qm74	4641	3	were	be	VBD
cord-015021-pol2qm74	4641	4	elevated	elevate	VBN
cord-015021-pol2qm74	4641	5	at	at	IN
cord-015021-pol2qm74	4641	6	205±28	205±28	CD
cord-015021-pol2qm74	4641	7	pg	pg	NNP
cord-015021-pol2qm74	4641	8	/	/	SYM
cord-015021-pol2qm74	4641	9	ml	ml	XX
cord-015021-pol2qm74	4641	10	at	at	RB
cord-015021-pol2qm74	4641	11	all	all	DT
cord-015021-pol2qm74	4641	12	time	time	NN
cord-015021-pol2qm74	4641	13	points	point	NNS
cord-015021-pol2qm74	4641	14	versus	versus	IN
cord-015021-pol2qm74	4641	15	levels	level	NNS
cord-015021-pol2qm74	4641	16	in	in	IN
cord-015021-pol2qm74	4641	17	healthy	healthy	JJ
cord-015021-pol2qm74	4641	18	controls	control	NNS
cord-015021-pol2qm74	4641	19	of	of	IN
cord-015021-pol2qm74	4641	20	39±9	39±9	CD
cord-015021-pol2qm74	4641	21	.	.	.
cord-015021-pol2qm74	4642	1	In	in	IN
cord-015021-pol2qm74	4642	2	summary	summary	NN
cord-015021-pol2qm74	4642	3	,	,	,
cord-015021-pol2qm74	4642	4	systemic	systemic	JJ
cord-015021-pol2qm74	4642	5	ET	ET	NNP
cord-015021-pol2qm74	4642	6	levels	level	NNS
cord-015021-pol2qm74	4642	7	increase	increase	VBP
cord-015021-pol2qm74	4642	8	significantly	significantly	RB
cord-015021-pol2qm74	4642	9	in	in	IN
cord-015021-pol2qm74	4642	10	patients	patient	NNS
cord-015021-pol2qm74	4642	11	with	with	IN
cord-015021-pol2qm74	4642	12	major	major	JJ
cord-015021-pol2qm74	4642	13	burns	burn	NNS
cord-015021-pol2qm74	4642	14	.	.	.
cord-015021-pol2qm74	4643	1	ET	ET	NNP
cord-015021-pol2qm74	4643	2	may	may	MD
cord-015021-pol2qm74	4643	3	be	be	VB
cord-015021-pol2qm74	4643	4	yet	yet	RB
cord-015021-pol2qm74	4643	5	another	another	DT
cord-015021-pol2qm74	4643	6	cytokine	cytokine	NN
cord-015021-pol2qm74	4643	7	playing	play	VBG
cord-015021-pol2qm74	4643	8	a	a	DT
cord-015021-pol2qm74	4643	9	significant	significant	JJ
cord-015021-pol2qm74	4643	10	role	role	NN
cord-015021-pol2qm74	4643	11	in	in	IN
cord-015021-pol2qm74	4643	12	the	the	DT
cord-015021-pol2qm74	4643	13	immune	immune	JJ
cord-015021-pol2qm74	4643	14	,	,	,
cord-015021-pol2qm74	4643	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4643	16	and	and	CC
cord-015021-pol2qm74	4643	17	multiorgan	multiorgan	NNP
cord-015021-pol2qm74	4643	18	dysfunction	dysfunction	NN
cord-015021-pol2qm74	4643	19	observed	observe	VBN
cord-015021-pol2qm74	4643	20	with	with	IN
cord-015021-pol2qm74	4643	21	major	major	JJ
cord-015021-pol2qm74	4643	22	burns	burn	NNS
cord-015021-pol2qm74	4643	23	.	.	.
cord-015021-pol2qm74	4644	1	Restoration	restoration	NN
cord-015021-pol2qm74	4644	2	processes	process	NNS
cord-015021-pol2qm74	4644	3	in	in	IN
cord-015021-pol2qm74	4644	4	an	an	DT
cord-015021-pol2qm74	4644	5	organism	organism	NN
cord-015021-pol2qm74	4644	6	after	after	IN
cord-015021-pol2qm74	4644	7	ischemic	ischemic	JJ
cord-015021-pol2qm74	4644	8	damage	damage	NN
cord-015021-pol2qm74	4644	9	are	be	VBP
cord-015021-pol2qm74	4644	10	realized	realize	VBN
cord-015021-pol2qm74	4644	11	through	through	IN
cord-015021-pol2qm74	4645	1	~n	~n	NNP
cord-015021-pol2qm74	4646	1	~lammatory	~lammatory	NNP
cord-015021-pol2qm74	4646	2	mechanisms~	mechanisms~	NN
cord-015021-pol2qm74	4647	1	the	the	DT
cord-015021-pol2qm74	4647	2	intensity	intensity	NN
cord-015021-pol2qm74	4647	3	of	of	IN
cord-015021-pol2qm74	4647	4	which	which	WDT
cord-015021-pol2qm74	4647	5	is	be	VBZ
cord-015021-pol2qm74	4647	6	significantly	significantly	RB
cord-015021-pol2qm74	4647	7	defined	define	VBN
cord-015021-pol2qm74	4647	8	by	by	IN
cord-015021-pol2qm74	4647	9	blood	blood	NN
cord-015021-pol2qm74	4647	10	levels	level	NNS
cord-015021-pol2qm74	4647	11	of	of	IN
cord-015021-pol2qm74	4647	12	neuropeptides	neuropeptide	NNS
cord-015021-pol2qm74	4647	13	.	.	.
cord-015021-pol2qm74	4648	1	Myocardial	myocardial	JJ
cord-015021-pol2qm74	4648	2	infarction	infarction	NN
cord-015021-pol2qm74	4648	3	(	(	-LRB-
cord-015021-pol2qm74	4648	4	MI	MI	NNP
cord-015021-pol2qm74	4648	5	)	)	-RRB-
cord-015021-pol2qm74	4648	6	was	be	VBD
cord-015021-pol2qm74	4648	7	chosen	choose	VBN
cord-015021-pol2qm74	4648	8	for	for	IN
cord-015021-pol2qm74	4648	9	studyin	studyin	NNP
cord-015021-pol2qm74	4648	10	9	9	CD
cord-015021-pol2qm74	4648	11	these	these	DT
cord-015021-pol2qm74	4648	12	processes	process	NNS
cord-015021-pol2qm74	4648	13	since	since	IN
cord-015021-pol2qm74	4648	14	it	-PRON-	PRP
cord-015021-pol2qm74	4648	15	eradicates	eradicate	VBZ
cord-015021-pol2qm74	4648	16	the	the	DT
cord-015021-pol2qm74	4648	17	influence	influence	NN
cord-015021-pol2qm74	4648	18	of	of	IN
cord-015021-pol2qm74	4648	19	infectious	infectious	JJ
cord-015021-pol2qm74	4648	20	factc	factc	NN
cord-015021-pol2qm74	4648	21	~	~	NFP
cord-015021-pol2qm74	4648	22	rs	rs	NN
cord-015021-pol2qm74	4648	23	.	.	.
cord-015021-pol2qm74	4649	1	32	32	CD
cord-015021-pol2qm74	4649	2	dogs~	dogs~	NNS
cord-015021-pol2qm74	4649	3	in	in	IN
cord-015021-pol2qm74	4649	4	whom	whom	WP
cord-015021-pol2qm74	4649	5	MI	MI	NNP
cord-015021-pol2qm74	4649	6	underwent	undergo	VBD
cord-015021-pol2qm74	4649	7	different	different	JJ
cord-015021-pol2qm74	4649	8	forms	form	NNS
cord-015021-pol2qm74	4649	9	o¢	o¢	NNP
cord-015021-pol2qm74	4649	10	healer	healer	NN
cord-015021-pol2qm74	4649	11	,	,	,
cord-015021-pol2qm74	4649	12	g	g	NN
cord-015021-pol2qm74	4649	13	;	;	:
cord-015021-pol2qm74	4649	14	bhn~	bhn~	NNP
cord-015021-pol2qm74	4650	1	ed	ed	NNP
cord-015021-pol2qm74	4651	1	~h	~h	NFP
cord-015021-pol2qm74	4651	2	~	~	NFP
cord-015021-pol2qm74	4651	3	t	t	XX
cord-015021-pol2qm74	4651	4	during	during	IN
cord-015021-pol2qm74	4651	5	the	the	DT
cord-015021-pol2qm74	4651	6	acute	acute	JJ
cord-015021-pol2qm74	4651	7	phase	phase	NN
cord-015021-pol2qm74	4651	8	of	of	IN
cord-015021-pol2qm74	4651	9	the	the	DT
cord-015021-pol2qm74	4651	10	disease	disease	NN
cord-015021-pol2qm74	4651	11	there	there	EX
cord-015021-pol2qm74	4651	12	was	be	VBD
cord-015021-pol2qm74	4651	13	a	a	DT
cord-015021-pol2qm74	4651	14	characteristic	characteristic	JJ
cord-015021-pol2qm74	4651	15	rise	rise	NN
cord-015021-pol2qm74	4651	16	of	of	IN
cord-015021-pol2qm74	4651	17	ne!~ropeptides	ne!~ropeptide	NNS
cord-015021-pol2qm74	4651	18	in	in	IN
cord-015021-pol2qm74	4651	19	the	the	DT
cord-015021-pol2qm74	4651	20	blood	blood	NN
cord-015021-pol2qm74	4651	21	.	.	.
cord-015021-pol2qm74	4652	1	These	these	DT
cord-015021-pol2qm74	4652	2	neuropeptides	neuropeptide	NNS
cord-015021-pol2qm74	4652	3	had	have	VBD
cord-015021-pol2qm74	4652	4	nociceptive	nociceptive	JJ
cord-015021-pol2qm74	4652	5	and	and	CC
cord-015021-pol2qm74	4652	6	antinociceptive	antinociceptive	JJ
cord-015021-pol2qm74	4652	7	effects	effect	NNS
cord-015021-pol2qm74	4652	8	.	.	.
cord-015021-pol2qm74	4653	1	Particularly	particularly	RB
cord-015021-pol2qm74	4653	2	substance	substance	NN
cord-015021-pol2qm74	4653	3	P	p	NN
cord-015021-pol2qm74	4653	4	and	and	CC
cord-015021-pol2qm74	4653	5	-endorphins	-endorphin	NNS
cord-015021-pol2qm74	4653	6	triggered	trigger	VBD
cord-015021-pol2qm74	4653	7	off	off	RP
cord-015021-pol2qm74	4653	8	the	the	DT
cord-015021-pol2qm74	4653	9	development	development	NN
cord-015021-pol2qm74	4653	10	of	of	IN
cord-015021-pol2qm74	4653	11	compensatory	compensatory	JJ
cord-015021-pol2qm74	4653	12	and	and	CC
cord-015021-pol2qm74	4653	13	adaptive	adaptive	JJ
cord-015021-pol2qm74	4653	14	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4653	15	and	and	CC
cord-015021-pol2qm74	4653	16	defined	define	VBD
cord-015021-pol2qm74	4653	17	the	the	DT
cord-015021-pol2qm74	4653	18	intensity	intensity	NN
cord-015021-pol2qm74	4653	19	of	of	IN
cord-015021-pol2qm74	4653	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4653	21	reaction	reaction	NN
cord-015021-pol2qm74	4653	22	at	at	IN
cord-015021-pol2qm74	4653	23	the	the	DT
cord-015021-pol2qm74	4653	24	zone	zone	NN
cord-015021-pol2qm74	4653	25	of	of	IN
cord-015021-pol2qm74	4653	26	ischem	ischem	NNP
cord-015021-pol2qm74	4654	1	~t	~t	JJ
cord-015021-pol2qm74	4654	2	:	:	:
cord-015021-pol2qm74	4654	3	damage	damage	NN
cord-015021-pol2qm74	4654	4	-	-	HYPH
cord-015021-pol2qm74	4654	5	Notable	notable	JJ
cord-015021-pol2qm74	4654	6	fall	fall	NN
cord-015021-pol2qm74	4654	7	in	in	IN
cord-015021-pol2qm74	4654	8	substance	substance	NN
cord-015021-pol2qm74	4654	9	P	p	NN
cord-015021-pol2qm74	4654	10	levels	level	NNS
cord-015021-pol2qm74	4654	11	after	after	IN
cord-015021-pol2qm74	4654	12	an	an	DT
cord-015021-pol2qm74	4654	13	~nitial	~nitial	CD
cord-015021-pol2qm74	4654	14	increase	increase	NN
cord-015021-pol2qm74	4654	15	,	,	,
cord-015021-pol2qm74	4654	16	while	while	IN
cord-015021-pol2qm74	4654	17	The	the	DT
cord-015021-pol2qm74	4654	18	~-endorphins	~-endorphin	NNS
cord-015021-pol2qm74	4654	19	stayed	stay	VBD
cord-015021-pol2qm74	4654	20	high	high	JJ
cord-015021-pol2qm74	4654	21	was	be	VBD
cord-015021-pol2qm74	4654	22	an	an	DT
cord-015021-pol2qm74	4654	23	important	important	JJ
cord-015021-pol2qm74	4654	24	condition	condition	NN
cord-015021-pol2qm74	4654	25	for	for	IN
cord-015021-pol2qm74	4654	26	non	non	JJ
cord-015021-pol2qm74	4654	27	complicated	complicated	JJ
cord-015021-pol2qm74	4654	28	healing	healing	NN
cord-015021-pol2qm74	4654	29	of	of	IN
cord-015021-pol2qm74	4654	30	MI	MI	NNP
cord-015021-pol2qm74	4654	31	.	.	.
cord-015021-pol2qm74	4655	1	On	on	IN
cord-015021-pol2qm74	4655	2	the	the	DT
cord-015021-pol2qm74	4655	3	other	other	JJ
cord-015021-pol2qm74	4655	4	hand	hand	NN
cord-015021-pol2qm74	4655	5	high	high	JJ
cord-015021-pol2qm74	4655	6	levels	level	NNS
cord-015021-pol2qm74	4655	7	of	of	IN
cord-015021-pol2qm74	4655	8	substance	substance	NN
cord-015021-pol2qm74	4655	9	P	p	NN
cord-015021-pol2qm74	4655	10	with	with	IN
cord-015021-pol2qm74	4655	11	low	low	JJ
cord-015021-pol2qm74	4655	12	~-endorphin	~-endorphin	NFP
cord-015021-pol2qm74	4655	13	concentrations	concentration	NNS
cord-015021-pol2qm74	4655	14	lead	lead	VBP
cord-015021-pol2qm74	4655	15	to	to	IN
cord-015021-pol2qm74	4655	16	increased	increase	VBN
cord-015021-pol2qm74	4655	17	infiltration	infiltration	NN
cord-015021-pol2qm74	4655	18	o~	o~	CD
cord-015021-pol2qm74	4655	19	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4655	20	into	into	IN
cord-015021-pol2qm74	4655	21	the	the	DT
cord-015021-pol2qm74	4655	22	infarction	infarction	NN
cord-015021-pol2qm74	4655	23	zone	zone	NN
cord-015021-pol2qm74	4655	24	and	and	CC
cord-015021-pol2qm74	4655	25	weakened	weaken	VBD
cord-015021-pol2qm74	4655	26	the	the	DT
cord-015021-pol2qm74	4655	27	activity	activity	NN
cord-015021-pol2qm74	4655	28	of	of	IN
cord-015021-pol2qm74	4655	29	synthetic	synthetic	JJ
cord-015021-pol2qm74	4655	30	processes~	processes~	NN
cord-015021-pol2qm74	4655	31	thereby	thereby	RB
cord-015021-pol2qm74	4655	32	leading	lead	VBG
cord-015021-pol2qm74	4655	33	to	to	IN
cord-015021-pol2qm74	4655	34	left	leave	VBN
cord-015021-pol2qm74	4655	35	ventricular	ventricular	JJ
cord-015021-pol2qm74	4655	36	aneurysm	aneurysm	NN
cord-015021-pol2qm74	4655	37	.	.	.
cord-015021-pol2qm74	4656	1	At	at	IN
cord-015021-pol2qm74	4656	2	the	the	DT
cord-015021-pol2qm74	4656	3	same	same	JJ
cord-015021-pol2qm74	4656	4	time	time	NN
cord-015021-pol2qm74	4656	5	low	low	JJ
cord-015021-pol2qm74	4656	6	intitial	intitial	JJ
cord-015021-pol2qm74	4656	7	levels	level	NNS
cord-015021-pol2qm74	4656	8	of	of	IN
cord-015021-pol2qm74	4656	9	substance	substance	NN
cord-015021-pol2qm74	4656	10	P	p	NN
cord-015021-pol2qm74	4656	11	slowed	slow	VBD
cord-015021-pol2qm74	4656	12	down	down	IN
cord-015021-pol2qm74	4656	13	the	the	DT
cord-015021-pol2qm74	4656	14	development	development	NN
cord-015021-pol2qm74	4656	15	of	of	IN
cord-015021-pol2qm74	4656	16	necrotic	necrotic	JJ
cord-015021-pol2qm74	4656	17	processes	process	NNS
cord-015021-pol2qm74	4656	18	which	which	WDT
cord-015021-pol2qm74	4656	19	lead	lead	VBP
cord-015021-pol2qm74	4656	20	to	to	TO
cord-015021-pol2qm74	4656	21	delay	delay	VB
cord-015021-pol2qm74	4656	22	in	in	IN
cord-015021-pol2qm74	4656	23	refunctioning	refunctioning	NN
cord-015021-pol2qm74	4656	24	of	of	IN
cord-015021-pol2qm74	4656	25	the	the	DT
cord-015021-pol2qm74	4656	26	heart	heart	NN
cord-015021-pol2qm74	4656	27	and	and	CC
cord-015021-pol2qm74	4656	28	complicated	complicate	VBD
cord-015021-pol2qm74	4656	29	the	the	DT
cord-015021-pol2qm74	4656	30	healing	healing	NN
cord-015021-pol2qm74	4656	31	process	process	NN
cord-015021-pol2qm74	4656	32	.	.	.
cord-015021-pol2qm74	4657	1	Thus	thus	RB
cord-015021-pol2qm74	4657	2	,	,	,
cord-015021-pol2qm74	4657	3	regulation	regulation	NN
cord-015021-pol2qm74	4657	4	of	of	IN
cord-015021-pol2qm74	4657	5	the	the	DT
cord-015021-pol2qm74	4657	6	levels	level	NNS
cord-015021-pol2qm74	4657	7	of	of	IN
cord-015021-pol2qm74	4657	8	neuropeptides	neuropeptide	NNS
cord-015021-pol2qm74	4657	9	in	in	IN
cord-015021-pol2qm74	4657	10	the	the	DT
cord-015021-pol2qm74	4657	11	blood	blood	NN
cord-015021-pol2qm74	4657	12	in	in	IN
cord-015021-pol2qm74	4657	13	trauma	trauma	NN
cord-015021-pol2qm74	4657	14	forms	form	VBZ
cord-015021-pol2qm74	4657	15	a	a	DT
cord-015021-pol2qm74	4657	16	perspective	perspective	NN
cord-015021-pol2qm74	4657	17	method	method	NN
cord-015021-pol2qm74	4657	18	of	of	IN
cord-015021-pol2qm74	4657	19	its	-PRON-	PRP$
cord-015021-pol2qm74	4657	20	treatment	treatment	NN
cord-015021-pol2qm74	4657	21	.	.	.
cord-015021-pol2qm74	4658	1	OF	of	IN
cord-015021-pol2qm74	4658	2	LAPARASCOPIC	LAPARASCOPIC	NNP
cord-015021-pol2qm74	4659	1	VERSUS	versu	NNS
cord-015021-pol2qm74	4659	2	OPEN	open	JJ
cord-015021-pol2qm74	4659	3	CHOLEOCYSTECTOMY	CHOLEOCYSTECTOMY	NNP
cord-015021-pol2qm74	4659	4	C.	C.	NNP
cord-015021-pol2qm74	4659	5	Schinkel	Schinkel	NNP
cord-015021-pol2qm74	4659	6	,	,	,
cord-015021-pol2qm74	4659	7	S.	S.	NNP
cord-015021-pol2qm74	4659	8	Zimmer	Zimmer	NNP
cord-015021-pol2qm74	4659	9	,	,	,
cord-015021-pol2qm74	4659	10	V.	V.	NNP
cord-015021-pol2qm74	4659	11	Lange	Lange	NNP
cord-015021-pol2qm74	4659	12	,	,	,
cord-015021-pol2qm74	4659	13	D.	D.	NNP
cord-015021-pol2qm74	4659	14	Fuchs	Fuchs	NNP
cord-015021-pol2qm74	4659	15	,	,	,
cord-015021-pol2qm74	4659	16	E.	E.	NNP
cord-015021-pol2qm74	4659	17	Faist	Faist	NNP
cord-015021-pol2qm74	4660	1	The	the	DT
cord-015021-pol2qm74	4660	2	impairment	impairment	NN
cord-015021-pol2qm74	4660	3	of	of	IN
cord-015021-pol2qm74	4660	4	immune	immune	JJ
cord-015021-pol2qm74	4660	5	function	function	NN
cord-015021-pol2qm74	4660	6	due	due	IN
cord-015021-pol2qm74	4660	7	to	to	IN
cord-015021-pol2qm74	4660	8	surgical	surgical	JJ
cord-015021-pol2qm74	4660	9	trauma	trauma	NN
cord-015021-pol2qm74	4660	10	may	may	MD
cord-015021-pol2qm74	4660	11	be	be	VB
cord-015021-pol2qm74	4660	12	followed	follow	VBN
cord-015021-pol2qm74	4660	13	by	by	IN
cord-015021-pol2qm74	4660	14	deleterious	deleterious	JJ
cord-015021-pol2qm74	4660	15	septic	septic	JJ
cord-015021-pol2qm74	4660	16	sequelae	sequela	NNS
cord-015021-pol2qm74	4660	17	.	.	.
cord-015021-pol2qm74	4661	1	Compared	compare	VBN
cord-015021-pol2qm74	4661	2	to	to	TO
cord-015021-pol2qm74	4661	3	open	open	VB
cord-015021-pol2qm74	4661	4	abdominal	abdominal	JJ
cord-015021-pol2qm74	4661	5	surgical	surgical	JJ
cord-015021-pol2qm74	4661	6	procedures	procedure	NNS
cord-015021-pol2qm74	4661	7	(	(	-LRB-
cord-015021-pol2qm74	4661	8	LAP	LAP	NNP
cord-015021-pol2qm74	4661	9	)	)	-RRB-
cord-015021-pol2qm74	4661	10	,	,	,
cord-015021-pol2qm74	4661	11	laparaseopic	laparaseopic	NNP
cord-015021-pol2qm74	4661	12	surgery	surgery	NN
cord-015021-pol2qm74	4661	13	(	(	-LRB-
cord-015021-pol2qm74	4661	14	LSC	LSC	NNP
cord-015021-pol2qm74	4661	15	)	)	-RRB-
cord-015021-pol2qm74	4661	16	is	be	VBZ
cord-015021-pol2qm74	4661	17	associated	associate	VBN
cord-015021-pol2qm74	4661	18	with	with	IN
cord-015021-pol2qm74	4661	19	a	a	DT
cord-015021-pol2qm74	4661	20	decrease	decrease	NN
cord-015021-pol2qm74	4661	21	in	in	IN
cord-015021-pol2qm74	4661	22	hospital	hospital	NN
cord-015021-pol2qm74	4661	23	stay	stay	NN
cord-015021-pol2qm74	4661	24	and	and	CC
cord-015021-pol2qm74	4661	25	in	in	IN
cord-015021-pol2qm74	4661	26	accelerated	accelerated	JJ
cord-015021-pol2qm74	4661	27	patient	patient	NN
cord-015021-pol2qm74	4661	28	recover	recover	VBP
cord-015021-pol2qm74	4661	29	.	.	.
cord-015021-pol2qm74	4662	1	The	the	DT
cord-015021-pol2qm74	4662	2	aim	aim	NN
cord-015021-pol2qm74	4662	3	of	of	IN
cord-015021-pol2qm74	4662	4	the	the	DT
cord-015021-pol2qm74	4662	5	study	study	NN
cord-015021-pol2qm74	4662	6	was	be	VBD
cord-015021-pol2qm74	4662	7	to	to	TO
cord-015021-pol2qm74	4662	8	evaluate	evaluate	VB
cord-015021-pol2qm74	4662	9	the	the	DT
cord-015021-pol2qm74	4662	10	sensitivity	sensitivity	NN
cord-015021-pol2qm74	4662	11	of	of	IN
cord-015021-pol2qm74	4662	12	the	the	DT
cord-015021-pol2qm74	4662	13	immune	immune	JJ
cord-015021-pol2qm74	4662	14	sermn	sermn	NN
cord-015021-pol2qm74	4662	15	parameters	parameter	NNS
cord-015021-pol2qm74	4662	16	of	of	IN
cord-015021-pol2qm74	4662	17	IL-6	IL-6	NNP
cord-015021-pol2qm74	4662	18	,	,	,
cord-015021-pol2qm74	4662	19	SAA	SAA	NNP
cord-015021-pol2qm74	4662	20	and	and	CC
cord-015021-pol2qm74	4662	21	neopterin	neopterin	NNP
cord-015021-pol2qm74	4662	22	,	,	,
cord-015021-pol2qm74	4662	23	the	the	DT
cord-015021-pol2qm74	4662	24	percentage	percentage	NN
cord-015021-pol2qm74	4662	25	of	of	IN
cord-015021-pol2qm74	4662	26	CD14	CD14	NNP
cord-015021-pol2qm74	4662	27	+	+	CC
cord-015021-pol2qm74	4662	28	cells	cell	NNS
cord-015021-pol2qm74	4662	29	,	,	,
cord-015021-pol2qm74	4662	30	the	the	DT
cord-015021-pol2qm74	4662	31	in	in	IN
cord-015021-pol2qm74	4662	32	-	-	HYPH
cord-015021-pol2qm74	4662	33	vitro	vitro	FW
cord-015021-pol2qm74	4662	34	IL-2	il-2	NN
cord-015021-pol2qm74	4662	35	synthesis	synthesis	NN
cord-015021-pol2qm74	4662	36	after	after	IN
cord-015021-pol2qm74	4662	37	mitogen	mitogen	NN
cord-015021-pol2qm74	4662	38	stimulation	stimulation	NN
cord-015021-pol2qm74	4662	39	and	and	CC
cord-015021-pol2qm74	4662	40	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4662	41	proliferation	proliferation	NN
cord-015021-pol2qm74	4662	42	,	,	,
cord-015021-pol2qm74	4662	43	in	in	IN
cord-015021-pol2qm74	4662	44	order	order	NN
cord-015021-pol2qm74	4662	45	to	to	TO
cord-015021-pol2qm74	4662	46	purposefully	purposefully	RB
cord-015021-pol2qm74	4662	47	discriminate	discriminate	VB
cord-015021-pol2qm74	4662	48	differences	difference	NNS
cord-015021-pol2qm74	4662	49	in	in	IN
cord-015021-pol2qm74	4662	50	the	the	DT
cord-015021-pol2qm74	4662	51	severity	severity	NN
cord-015021-pol2qm74	4662	52	of	of	IN
cord-015021-pol2qm74	4662	53	trauma	trauma	NN
cord-015021-pol2qm74	4662	54	.	.	.
cord-015021-pol2qm74	4663	1	We	-PRON-	PRP
cord-015021-pol2qm74	4663	2	investigated	investigate	VBD
cord-015021-pol2qm74	4663	3	the	the	DT
cord-015021-pol2qm74	4663	4	blood	blood	NN
cord-015021-pol2qm74	4663	5	of	of	IN
cord-015021-pol2qm74	4663	6	27	27	CD
cord-015021-pol2qm74	4663	7	patients	patient	NNS
cord-015021-pol2qm74	4663	8	with	with	IN
cord-015021-pol2qm74	4663	9	cholecystolithiasis	cholecystolithiasis	NN
cord-015021-pol2qm74	4663	10	undergoing	undergo	VBG
cord-015021-pol2qm74	4663	11	either	either	CC
cord-015021-pol2qm74	4663	12	laparascopic	laparascopic	NNP
cord-015021-pol2qm74	4663	13	(	(	-LRB-
cord-015021-pol2qm74	4663	14	16	16	CD
cord-015021-pol2qm74	4663	15	)	)	-RRB-
cord-015021-pol2qm74	4663	16	or	or	CC
cord-015021-pol2qm74	4663	17	open	open	JJ
cord-015021-pol2qm74	4663	18	(	(	-LRB-
cord-015021-pol2qm74	4663	19	I	i	NN
cord-015021-pol2qm74	4663	20	1	1	CD
cord-015021-pol2qm74	4663	21	)	)	-RRB-
cord-015021-pol2qm74	4664	1	cholecystectomy	cholecystectomy	NN
cord-015021-pol2qm74	4664	2	on	on	IN
cord-015021-pol2qm74	4664	3	consecutive	consecutive	JJ
cord-015021-pol2qm74	4664	4	perioperative	perioperative	JJ
cord-015021-pol2qm74	4664	5	days	day	NNS
cord-015021-pol2qm74	4664	6	-1	-1	JJ
cord-015021-pol2qm74	4664	7	,	,	,
cord-015021-pol2qm74	4664	8	1	1	CD
cord-015021-pol2qm74	4664	9	,	,	,
cord-015021-pol2qm74	4664	10	2	2	CD
cord-015021-pol2qm74	4664	11	and	and	CC
cord-015021-pol2qm74	4664	12	3	3	CD
cord-015021-pol2qm74	4664	13	.	.	.
cord-015021-pol2qm74	4665	1	There	there	EX
cord-015021-pol2qm74	4665	2	was	be	VBD
cord-015021-pol2qm74	4665	3	no	no	DT
cord-015021-pol2qm74	4665	4	significant	significant	JJ
cord-015021-pol2qm74	4665	5	difference	difference	NN
cord-015021-pol2qm74	4665	6	between	between	IN
cord-015021-pol2qm74	4665	7	the	the	DT
cord-015021-pol2qm74	4665	8	two	two	CD
cord-015021-pol2qm74	4665	9	groups	group	NNS
cord-015021-pol2qm74	4665	10	concerning	concern	VBG
cord-015021-pol2qm74	4665	11	age	age	NN
cord-015021-pol2qm74	4665	12	and	and	CC
cord-015021-pol2qm74	4665	13	sex	sex	NN
cord-015021-pol2qm74	4665	14	.	.	.
cord-015021-pol2qm74	4666	1	Patients	patient	NNS
cord-015021-pol2qm74	4666	2	with	with	IN
cord-015021-pol2qm74	4666	3	clinical	clinical	JJ
cord-015021-pol2qm74	4666	4	signs	sign	NNS
cord-015021-pol2qm74	4666	5	of	of	IN
cord-015021-pol2qm74	4666	6	acute	acute	JJ
cord-015021-pol2qm74	4666	7	cholecystitis	cholecystitis	NN
cord-015021-pol2qm74	4666	8	were	be	VBD
cord-015021-pol2qm74	4666	9	excluded	exclude	VBN
cord-015021-pol2qm74	4666	10	from	from	IN
cord-015021-pol2qm74	4666	11	the	the	DT
cord-015021-pol2qm74	4666	12	study	study	NN
cord-015021-pol2qm74	4666	13	.	.	.
cord-015021-pol2qm74	4667	1	Operation	operation	NN
cord-015021-pol2qm74	4667	2	time	time	NN
cord-015021-pol2qm74	4667	3	and	and	CC
cord-015021-pol2qm74	4667	4	hospital	hospital	NN
cord-015021-pol2qm74	4667	5	stay	stay	NN
cord-015021-pol2qm74	4667	6	were	be	VBD
cord-015021-pol2qm74	4667	7	obviously	obviously	RB
cord-015021-pol2qm74	4667	8	longer	long	JJR
cord-015021-pol2qm74	4667	9	in	in	IN
cord-015021-pol2qm74	4667	10	LAP	lap	NN
cord-015021-pol2qm74	4667	11	patients	patient	NNS
cord-015021-pol2qm74	4667	12	(	(	-LRB-
cord-015021-pol2qm74	4667	13	67	67	CD
cord-015021-pol2qm74	4667	14	versus	versus	IN
cord-015021-pol2qm74	4667	15	145	145	CD
cord-015021-pol2qm74	4667	16	minutes	minute	NNS
cord-015021-pol2qm74	4667	17	,	,	,
cord-015021-pol2qm74	4667	18	5	5	CD
cord-015021-pol2qm74	4667	19	versus	versus	IN
cord-015021-pol2qm74	4667	20	20	20	CD
cord-015021-pol2qm74	4667	21	days	day	NNS
cord-015021-pol2qm74	4667	22	)	)	-RRB-
cord-015021-pol2qm74	4667	23	compared	compare	VBN
cord-015021-pol2qm74	4667	24	to	to	IN
cord-015021-pol2qm74	4667	25	the	the	DT
cord-015021-pol2qm74	4667	26	LSC	LSC	NNP
cord-015021-pol2qm74	4667	27	group	group	NN
cord-015021-pol2qm74	4667	28	.	.	.
cord-015021-pol2qm74	4668	1	Concerning	concern	VBG
cord-015021-pol2qm74	4668	2	the	the	DT
cord-015021-pol2qm74	4668	3	unspecific	unspecific	JJ
cord-015021-pol2qm74	4668	4	acute	acute	JJ
cord-015021-pol2qm74	4668	5	phase	phase	NN
cord-015021-pol2qm74	4668	6	reaction	reaction	NN
cord-015021-pol2qm74	4668	7	we	-PRON-	PRP
cord-015021-pol2qm74	4668	8	could	could	MD
cord-015021-pol2qm74	4668	9	show	show	VB
cord-015021-pol2qm74	4668	10	no	no	DT
cord-015021-pol2qm74	4668	11	difference	difference	NN
cord-015021-pol2qm74	4668	12	in	in	IN
cord-015021-pol2qm74	4668	13	the	the	DT
cord-015021-pol2qm74	4668	14	increment	increment	NN
cord-015021-pol2qm74	4668	15	of	of	IN
cord-015021-pol2qm74	4668	16	senun	senun	NNS
cord-015021-pol2qm74	4668	17	amyoid	amyoid	NNP
cord-015021-pol2qm74	4668	18	A	A	NNP
cord-015021-pol2qm74	4668	19	(	(	-LRB-
cord-015021-pol2qm74	4668	20	SAA	SAA	NNP
cord-015021-pol2qm74	4668	21	)	)	-RRB-
cord-015021-pol2qm74	4668	22	synthesis	synthesis	NN
cord-015021-pol2qm74	4668	23	in	in	IN
cord-015021-pol2qm74	4668	24	the	the	DT
cord-015021-pol2qm74	4668	25	LSC	LSC	NNP
cord-015021-pol2qm74	4668	26	group	group	NN
cord-015021-pol2qm74	4668	27	(	(	-LRB-
cord-015021-pol2qm74	4668	28	D-	d-	XX
cord-015021-pol2qm74	4669	1	I	-PRON-	PRP
cord-015021-pol2qm74	4669	2	40	40	CD
cord-015021-pol2qm74	4669	3	+	+	SYM
cord-015021-pol2qm74	4669	4	1	1	CD
cord-015021-pol2qm74	4669	5	lng	lng	NN
cord-015021-pol2qm74	4669	6	/	/	SYM
cord-015021-pol2qm74	4669	7	ml	ml	NNP
cord-015021-pol2qm74	4669	8	,	,	,
cord-015021-pol2qm74	4669	9	D1	D1	NNP
cord-015021-pol2qm74	4669	10	362	362	CD
cord-015021-pol2qm74	4669	11	+	+	SYM
cord-015021-pol2qm74	4669	12	43ng	43ng	NN
cord-015021-pol2qm74	4669	13	/	/	SYM
cord-015021-pol2qm74	4669	14	ml	ml	NN
cord-015021-pol2qm74	4669	15	)	)	-RRB-
cord-015021-pol2qm74	4669	16	versus	versus	IN
cord-015021-pol2qm74	4669	17	LAP	lap	NN
cord-015021-pol2qm74	4669	18	group	group	NN
cord-015021-pol2qm74	4669	19	(	(	-LRB-
cord-015021-pol2qm74	4670	1	D-1	D-1	NNP
cord-015021-pol2qm74	4670	2	61	61	CD
cord-015021-pol2qm74	4670	3	+	+	SYM
cord-015021-pol2qm74	4670	4	19ng	19ng	NN
cord-015021-pol2qm74	4670	5	/	/	SYM
cord-015021-pol2qm74	4670	6	ml	ml	NN
cord-015021-pol2qm74	4670	7	,	,	,
cord-015021-pol2qm74	4670	8	D1	D1	NNP
cord-015021-pol2qm74	4670	9	457	457	CD
cord-015021-pol2qm74	4670	10	+	+	SYM
cord-015021-pol2qm74	4670	11	45ng	45ng	NN
cord-015021-pol2qm74	4670	12	/	/	SYM
cord-015021-pol2qm74	4670	13	ml	ml	NN
cord-015021-pol2qm74	4670	14	)	)	-RRB-
cord-015021-pol2qm74	4670	15	,	,	.
cord-015021-pol2qm74	4671	1	while	while	IN
cord-015021-pol2qm74	4671	2	in	in	IN
cord-015021-pol2qm74	4671	3	serum	serum	NN
cord-015021-pol2qm74	4671	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	4671	5	levels	level	NNS
cord-015021-pol2qm74	4671	6	we	-PRON-	PRP
cord-015021-pol2qm74	4671	7	saw	see	VBD
cord-015021-pol2qm74	4671	8	a	a	DT
cord-015021-pol2qm74	4671	9	less	less	RBR
cord-015021-pol2qm74	4671	10	steep	steep	JJ
cord-015021-pol2qm74	4671	11	increment	increment	NN
cord-015021-pol2qm74	4671	12	in	in	IN
cord-015021-pol2qm74	4671	13	the	the	DT
cord-015021-pol2qm74	4671	14	LSC	LSC	NNP
cord-015021-pol2qm74	4671	15	group	group	NN
cord-015021-pol2qm74	4671	16	(	(	-LRB-
cord-015021-pol2qm74	4671	17	7-fold	7-fold	CD
cord-015021-pol2qm74	4671	18	from	from	IN
cord-015021-pol2qm74	4671	19	D-1	D-1	NNP
cord-015021-pol2qm74	4671	20	to	to	IN
cord-015021-pol2qm74	4671	21	D	d	NN
cord-015021-pol2qm74	4671	22	1	1	CD
cord-015021-pol2qm74	4671	23	)	)	-RRB-
cord-015021-pol2qm74	4671	24	compared	compare	VBN
cord-015021-pol2qm74	4671	25	to	to	IN
cord-015021-pol2qm74	4671	26	the	the	DT
cord-015021-pol2qm74	4671	27	LAP	LAP	NNP
cord-015021-pol2qm74	4671	28	group	group	NN
cord-015021-pol2qm74	4671	29	(	(	-LRB-
cord-015021-pol2qm74	4671	30	10-fold	10-fold	JJ
cord-015021-pol2qm74	4671	31	from	from	IN
cord-015021-pol2qm74	4671	32	D-1	D-1	NNP
cord-015021-pol2qm74	4671	33	to	to	IN
cord-015021-pol2qm74	4671	34	D	d	NN
cord-015021-pol2qm74	4671	35	1	1	CD
cord-015021-pol2qm74	4671	36	)	)	-RRB-
cord-015021-pol2qm74	4671	37	.	.	.
cord-015021-pol2qm74	4672	1	The	the	DT
cord-015021-pol2qm74	4672	2	analysis	analysis	NN
cord-015021-pol2qm74	4672	3	of	of	IN
cord-015021-pol2qm74	4672	4	CD14	CD14	NNP
cord-015021-pol2qm74	4672	5	+	+	CC
cord-015021-pol2qm74	4672	6	receptor	receptor	NN
cord-015021-pol2qm74	4672	7	expression	expression	NN
cord-015021-pol2qm74	4672	8	and	and	CC
cord-015021-pol2qm74	4672	9	serum	serum	NN
cord-015021-pol2qm74	4672	10	neopterin	neopterin	NNP
cord-015021-pol2qm74	4672	11	did	do	VBD
cord-015021-pol2qm74	4672	12	not	not	RB
cord-015021-pol2qm74	4672	13	reveal	reveal	VB
cord-015021-pol2qm74	4672	14	any	any	DT
cord-015021-pol2qm74	4672	15	difference	difference	NN
cord-015021-pol2qm74	4672	16	between	between	IN
cord-015021-pol2qm74	4672	17	the	the	DT
cord-015021-pol2qm74	4672	18	groups	group	NNS
cord-015021-pol2qm74	4672	19	.	.	.
cord-015021-pol2qm74	4673	1	Lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4673	2	function	function	NN
cord-015021-pol2qm74	4673	3	showed	show	VBD
cord-015021-pol2qm74	4673	4	an	an	DT
cord-015021-pol2qm74	4673	5	impairment	impairment	NN
cord-015021-pol2qm74	4673	6	of	of	IN
cord-015021-pol2qm74	4673	7	proliferation	proliferation	NN
cord-015021-pol2qm74	4673	8	to	to	IN
cord-015021-pol2qm74	4673	9	antigen	antigen	NN
cord-015021-pol2qm74	4673	10	stimulation	stimulation	NN
cord-015021-pol2qm74	4673	11	in	in	IN
cord-015021-pol2qm74	4673	12	LAP	lap	NN
cord-015021-pol2qm74	4673	13	(	(	-LRB-
cord-015021-pol2qm74	4673	14	D	D	NNP
cord-015021-pol2qm74	4673	15	-1:24.000	-1:24.000	NNP
cord-015021-pol2qm74	4673	16	+	+	SYM
cord-015021-pol2qm74	4673	17	3.330	3.330	CD
cord-015021-pol2qm74	4673	18	cpm	cpm	NNP
cord-015021-pol2qm74	4673	19	,	,	,
cord-015021-pol2qm74	4673	20	D	D	NNP
cord-015021-pol2qm74	4673	21	1:17.300	1:17.300	CD
cord-015021-pol2qm74	4673	22	+	+	SYM
cord-015021-pol2qm74	4673	23	3.000	3.000	CD
cord-015021-pol2qm74	4673	24	cpm	cpm	NN
cord-015021-pol2qm74	4673	25	)	)	-RRB-
cord-015021-pol2qm74	4673	26	compared	compare	VBN
cord-015021-pol2qm74	4673	27	to	to	IN
cord-015021-pol2qm74	4673	28	the	the	DT
cord-015021-pol2qm74	4673	29	LSC	LSC	NNP
cord-015021-pol2qm74	4673	30	group	group	NN
cord-015021-pol2qm74	4673	31	(	(	-LRB-
cord-015021-pol2qm74	4673	32	D	D	NNP
cord-015021-pol2qm74	4673	33	-h	-h	NNP
cord-015021-pol2qm74	4673	34	22.500	22.500	CD
cord-015021-pol2qm74	4673	35	+	+	SYM
cord-015021-pol2qm74	4673	36	4.200	4.200	CD
cord-015021-pol2qm74	4673	37	cpm	cpm	NN
cord-015021-pol2qm74	4673	38	,	,	,
cord-015021-pol2qm74	4673	39	D	D	NNP
cord-015021-pol2qm74	4673	40	h	h	NN
cord-015021-pol2qm74	4673	41	26.000	26.000	CD
cord-015021-pol2qm74	4673	42	+	+	SYM
cord-015021-pol2qm74	4673	43	2.900	2.900	CD
cord-015021-pol2qm74	4673	44	cpm	cpm	NNP
cord-015021-pol2qm74	4673	45	)	)	-RRB-
cord-015021-pol2qm74	4673	46	.	.	.
cord-015021-pol2qm74	4674	1	In	in	IN
cord-015021-pol2qm74	4674	2	both	both	DT
cord-015021-pol2qm74	4674	3	groups	group	NNS
cord-015021-pol2qm74	4674	4	IL-2	IL-2	NNP
cord-015021-pol2qm74	4674	5	synthesis	synthesis	NN
cord-015021-pol2qm74	4674	6	was	be	VBD
cord-015021-pol2qm74	4674	7	decreased	decrease	VBN
cord-015021-pol2qm74	4674	8	post	post	RB
cord-015021-pol2qm74	4674	9	-	-	JJ
cord-015021-pol2qm74	4674	10	operatively	operatively	RB
cord-015021-pol2qm74	4674	11	.	.	.
cord-015021-pol2qm74	4675	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	4675	2	data	datum	NNS
cord-015021-pol2qm74	4675	3	indicate	indicate	VBP
cord-015021-pol2qm74	4675	4	that	that	IN
cord-015021-pol2qm74	4675	5	laparascopic	laparascopic	NNP
cord-015021-pol2qm74	4675	6	cholecystectomy	cholecystectomy	NN
cord-015021-pol2qm74	4675	7	reusults	reusults	NNP
cord-015021-pol2qm74	4675	8	in	in	IN
cord-015021-pol2qm74	4675	9	a	a	DT
cord-015021-pol2qm74	4675	10	less	less	RBR
cord-015021-pol2qm74	4675	11	distinct	distinct	JJ
cord-015021-pol2qm74	4675	12	unspecific	unspecific	JJ
cord-015021-pol2qm74	4675	13	acute	acute	JJ
cord-015021-pol2qm74	4675	14	phase	phase	NN
cord-015021-pol2qm74	4675	15	reaction	reaction	NN
cord-015021-pol2qm74	4675	16	post	post	NN
cord-015021-pol2qm74	4675	17	-	-	NN
cord-015021-pol2qm74	4675	18	trauma	trauma	NN
cord-015021-pol2qm74	4675	19	compared	compare	VBN
cord-015021-pol2qm74	4675	20	to	to	IN
cord-015021-pol2qm74	4675	21	that	that	DT
cord-015021-pol2qm74	4675	22	following	follow	VBG
cord-015021-pol2qm74	4675	23	LAP	lap	NN
cord-015021-pol2qm74	4675	24	.	.	.
cord-015021-pol2qm74	4676	1	Neopterin	neopterin	JJ
cord-015021-pol2qm74	4676	2	serum	serum	NN
cord-015021-pol2qm74	4676	3	levels	level	NNS
cord-015021-pol2qm74	4676	4	and	and	CC
cord-015021-pol2qm74	4676	5	CD14	CD14	NNP
cord-015021-pol2qm74	4676	6	receptor	receptor	NN
cord-015021-pol2qm74	4676	7	expression	expression	NN
cord-015021-pol2qm74	4676	8	show	show	VBP
cord-015021-pol2qm74	4676	9	that	that	IN
cord-015021-pol2qm74	4676	10	these	these	DT
cord-015021-pol2qm74	4676	11	parameters	parameter	NNS
cord-015021-pol2qm74	4676	12	apparently	apparently	RB
cord-015021-pol2qm74	4676	13	are	be	VBP
cord-015021-pol2qm74	4676	14	less	less	RBR
cord-015021-pol2qm74	4676	15	useful	useful	JJ
cord-015021-pol2qm74	4676	16	markers	marker	NNS
cord-015021-pol2qm74	4676	17	to	to	TO
cord-015021-pol2qm74	4676	18	detect	detect	VB
cord-015021-pol2qm74	4676	19	differences	difference	NNS
cord-015021-pol2qm74	4676	20	of	of	IN
cord-015021-pol2qm74	4676	21	surgical	surgical	JJ
cord-015021-pol2qm74	4676	22	trauma	trauma	NN
cord-015021-pol2qm74	4676	23	severity	severity	NN
cord-015021-pol2qm74	4676	24	while	while	IN
cord-015021-pol2qm74	4676	25	it	-PRON-	PRP
cord-015021-pol2qm74	4676	26	appears	appear	VBZ
cord-015021-pol2qm74	4676	27	that	that	IN
cord-015021-pol2qm74	4676	28	the	the	DT
cord-015021-pol2qm74	4676	29	impact	impact	NN
cord-015021-pol2qm74	4676	30	of	of	IN
cord-015021-pol2qm74	4676	31	LAP	lap	NN
cord-015021-pol2qm74	4676	32	is	be	VBZ
cord-015021-pol2qm74	4676	33	reflected	reflect	VBN
cord-015021-pol2qm74	4676	34	most	most	RBS
cord-015021-pol2qm74	4676	35	impressively	impressively	RB
cord-015021-pol2qm74	4676	36	on	on	IN
cord-015021-pol2qm74	4676	37	the	the	DT
cord-015021-pol2qm74	4676	38	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4676	39	compartment	compartment	NN
cord-015021-pol2qm74	4676	40	.	.	.
cord-015021-pol2qm74	4676	41	 	 	_SP
cord-015021-pol2qm74	4677	1	Trauma	trauma	NN
cord-015021-pol2qm74	4677	2	alters	alter	VBZ
cord-015021-pol2qm74	4677	3	the	the	DT
cord-015021-pol2qm74	4677	4	host	host	NN
cord-015021-pol2qm74	4677	5	resistance	resistance	NN
cord-015021-pol2qm74	4677	6	of	of	IN
cord-015021-pol2qm74	4677	7	organism	organism	NN
cord-015021-pol2qm74	4677	8	and	and	CC
cord-015021-pol2qm74	4677	9	is	be	VBZ
cord-015021-pol2qm74	4677	10	accompained	accompaine	VBN
cord-015021-pol2qm74	4677	11	by	by	IN
cord-015021-pol2qm74	4677	12	appearence	appearence	NN
cord-015021-pol2qm74	4677	13	of	of	IN
cord-015021-pol2qm74	4677	14	excgenic	excgenic	NNP
cord-015021-pol2qm74	4677	15	and	and	CC
cord-015021-pol2qm74	4677	16	endogenic	endogenic	NNP
cord-015021-pol2qm74	4677	17	proteins	protein	NNS
cord-015021-pol2qm74	4677	18	in	in	IN
cord-015021-pol2qm74	4677	19	the	the	DT
cord-015021-pol2qm74	4677	20	body	body	NN
cord-015021-pol2qm74	4677	21	.	.	.
cord-015021-pol2qm74	4678	1	To	to	TO
cord-015021-pol2qm74	4678	2	understand	understand	VB
cord-015021-pol2qm74	4678	3	the	the	DT
cord-015021-pol2qm74	4678	4	molecular	molecular	JJ
cord-015021-pol2qm74	4678	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4678	6	of	of	IN
cord-015021-pol2qm74	4678	7	host	host	NN
cord-015021-pol2qm74	4678	8	resistans	resistan	NNS
cord-015021-pol2qm74	4678	9	disorders	disorder	NNS
cord-015021-pol2qm74	4678	10	in	in	IN
cord-015021-pol2qm74	4678	11	trauma	trauma	NN
cord-015021-pol2qm74	4678	12	,	,	,
cord-015021-pol2qm74	4678	13	as	as	IN
cord-015021-pol2qm74	4678	14	a	a	DT
cord-015021-pol2qm74	4678	15	first	first	JJ
cord-015021-pol2qm74	4678	16	step	step	NN
cord-015021-pol2qm74	4678	17	,	,	,
cord-015021-pol2qm74	4678	18	the	the	DT
cord-015021-pol2qm74	4678	19	genetic	genetic	JJ
cord-015021-pol2qm74	4678	20	regulatory	regulatory	JJ
cord-015021-pol2qm74	4678	21	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4678	22	of	of	IN
cord-015021-pol2qm74	4678	23	immune	immune	JJ
cord-015021-pol2qm74	4678	24	response	response	NN
cord-015021-pol2qm74	4678	25	after	after	IN
cord-015021-pol2qm74	4678	26	antigen	antigen	NN
cord-015021-pol2qm74	4678	27	injection	injection	NN
cord-015021-pol2qm74	4678	28	has	have	VBZ
cord-015021-pol2qm74	4678	29	been	be	VBN
cord-015021-pol2qm74	4678	30	studed	stud	VBN
cord-015021-pol2qm74	4678	31	.	.	.
cord-015021-pol2qm74	4679	1	The	the	DT
cord-015021-pol2qm74	4679	2	appearence	appearence	NN
cord-015021-pol2qm74	4679	3	of	of	IN
cord-015021-pol2qm74	4679	4	specific	specific	JJ
cord-015021-pol2qm74	4679	5	protein	protein	NN
cord-015021-pol2qm74	4679	6	factors	factor	NNS
cord-015021-pol2qm74	4679	7	(	(	-LRB-
cord-015021-pol2qm74	4679	8	13	13	CD
cord-015021-pol2qm74	4679	9	-	-	SYM
cord-015021-pol2qm74	4679	10	19	19	CD
cord-015021-pol2qm74	4679	11	and	and	CC
cord-015021-pol2qm74	4679	12	25	25	CD
cord-015021-pol2qm74	4679	13	kDa	kDa	NNS
cord-015021-pol2qm74	4679	14	)	)	-RRB-
cord-015021-pol2qm74	4679	15	,	,	,
cord-015021-pol2qm74	4679	16	in	in	IN
cord-015021-pol2qm74	4679	17	the	the	DT
cord-015021-pol2qm74	4679	18	nucleus	nucleus	NN
cord-015021-pol2qm74	4679	19	of	of	IN
cord-015021-pol2qm74	4679	20	rat	rat	NN
cord-015021-pol2qm74	4679	21	splenic	splenic	NN
cord-015021-pol2qm74	4679	22	and	and	CC
cord-015021-pol2qm74	4679	23	brain	brain	NN
cord-015021-pol2qm74	4679	24	cells	cell	NNS
cord-015021-pol2qm74	4679	25	,	,	,
cord-015021-pol2qm74	4679	26	accordingly	accordingly	RB
cord-015021-pol2qm74	4679	27	,	,	,
cord-015021-pol2qm74	4679	28	was	be	VBD
cord-015021-pol2qm74	4679	29	shown	show	VBN
cord-015021-pol2qm74	4679	30	after	after	IN
cord-015021-pol2qm74	4679	31	immunization	immunization	NN
cord-015021-pol2qm74	4679	32	with	with	IN
cord-015021-pol2qm74	4679	33	sheep	sheep	NN
cord-015021-pol2qm74	4679	34	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	4679	35	.	.	.
cord-015021-pol2qm74	4680	1	The	the	DT
cord-015021-pol2qm74	4680	2	stimulatory	stimulatory	JJ
cord-015021-pol2qm74	4680	3	effect	effect	NN
cord-015021-pol2qm74	4680	4	of	of	IN
cord-015021-pol2qm74	4680	5	these	these	DT
cord-015021-pol2qm74	4680	6	factors	factor	NNS
cord-015021-pol2qm74	4680	7	on	on	IN
cord-015021-pol2qm74	4680	8	the	the	DT
cord-015021-pol2qm74	4680	9	IL-2	IL-2	NNP
cord-015021-pol2qm74	4680	10	mRNA	mRNA	NNP
cord-015021-pol2qm74	4680	11	and	and	CC
cord-015021-pol2qm74	4680	12	IL-2	IL-2	NNP
cord-015021-pol2qm74	4680	13	production	production	NN
cord-015021-pol2qm74	4680	14	was	be	VBD
cord-015021-pol2qm74	4680	15	detected	detect	VBN
cord-015021-pol2qm74	4680	16	.	.	.
cord-015021-pol2qm74	4681	1	The	the	DT
cord-015021-pol2qm74	4681	2	nucleotide	nucleotide	JJ
cord-015021-pol2qm74	4681	3	sequences	sequence	NNS
cord-015021-pol2qm74	4681	4	of	of	IN
cord-015021-pol2qm74	4681	5	the	the	DT
cord-015021-pol2qm74	4681	6	human	human	JJ
cord-015021-pol2qm74	4681	7	IL-2	IL-2	NNP
cord-015021-pol2qm74	4681	8	gene	gene	NN
cord-015021-pol2qm74	4681	9	regulatory	regulatory	JJ
cord-015021-pol2qm74	4681	10	region	region	NN
cord-015021-pol2qm74	4681	11	bounding	bound	VBG
cord-015021-pol2qm74	4681	12	by	by	IN
cord-015021-pol2qm74	4681	13	the	the	DT
cord-015021-pol2qm74	4681	14	splenic	splenic	JJ
cord-015021-pol2qm74	4681	15	nuclear	nuclear	JJ
cord-015021-pol2qm74	4681	16	proteins	protein	NNS
cord-015021-pol2qm74	4681	17	were	be	VBD
cord-015021-pol2qm74	4681	18	determined	determine	VBN
cord-015021-pol2qm74	4681	19	between	between	IN
cord-015021-pol2qm74	4681	20	+39	+39	CD
cord-015021-pol2qm74	4681	21	-	-	SYM
cord-015021-pol2qm74	4681	22	141	141	CD
cord-015021-pol2qm74	4681	23	b.p	b.p	NNS
cord-015021-pol2qm74	4681	24	.	.	.
cord-015021-pol2qm74	4682	1	The	the	DT
cord-015021-pol2qm74	4682	2	IL-2	IL-2	NNP
cord-015021-pol2qm74	4682	3	trans	trans	NNP
cord-015021-pol2qm74	4682	4	-	-	NNS
cord-015021-pol2qm74	4682	5	factors	factor	NNS
cord-015021-pol2qm74	4682	6	shows	show	VBZ
cord-015021-pol2qm74	4682	7	the	the	DT
cord-015021-pol2qm74	4682	8	affinity	affinity	NN
cord-015021-pol2qm74	4682	9	to	to	IN
cord-015021-pol2qm74	4682	10	splenic	splenic	JJ
cord-015021-pol2qm74	4682	11	and	and	CC
cord-015021-pol2qm74	4682	12	thymic	thymic	JJ
cord-015021-pol2qm74	4682	13	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4682	14	in	in	IN
cord-015021-pol2qm74	4682	15	vitro	vitro	FW
cord-015021-pol2qm74	4682	16	.	.	.
cord-015021-pol2qm74	4683	1	Thus	thus	RB
cord-015021-pol2qm74	4683	2	,	,	,
cord-015021-pol2qm74	4683	3	the	the	DT
cord-015021-pol2qm74	4683	4	antigen	antigen	NN
cord-015021-pol2qm74	4683	5	causes	cause	VBZ
cord-015021-pol2qm74	4683	6	the	the	DT
cord-015021-pol2qm74	4683	7	appearence	appearence	NN
cord-015021-pol2qm74	4683	8	of	of	IN
cord-015021-pol2qm74	4683	9	specific	specific	JJ
cord-015021-pol2qm74	4683	10	protein	protein	NN
cord-015021-pol2qm74	4683	11	factors	factor	NNS
cord-015021-pol2qm74	4683	12	in	in	IN
cord-015021-pol2qm74	4683	13	the	the	DT
cord-015021-pol2qm74	4683	14	cells	cell	NNS
cord-015021-pol2qm74	4683	15	,	,	,
cord-015021-pol2qm74	4683	16	which	which	WDT
cord-015021-pol2qm74	4683	17	act	act	VBP
cord-015021-pol2qm74	4683	18	on	on	IN
cord-015021-pol2qm74	4683	19	the	the	DT
cord-015021-pol2qm74	4683	20	gene	gene	NN
cord-015021-pol2qm74	4683	21	level	level	NN
cord-015021-pol2qm74	4683	22	,	,	,
cord-015021-pol2qm74	4683	23	stimulate	stimulate	VB
cord-015021-pol2qm74	4683	24	IL-2	il-2	NN
cord-015021-pol2qm74	4683	25	production	production	NN
cord-015021-pol2qm74	4683	26	and	and	CC
cord-015021-pol2qm74	4683	27	the	the	DT
cord-015021-pol2qm74	4683	28	host	host	NN
cord-015021-pol2qm74	4683	29	resistance	resistance	NN
cord-015021-pol2qm74	4683	30	.	.	.
cord-015021-pol2qm74	4684	1	These	these	DT
cord-015021-pol2qm74	4684	2	results	result	NNS
cord-015021-pol2qm74	4684	3	cause	cause	VBP
cord-015021-pol2qm74	4684	4	the	the	DT
cord-015021-pol2qm74	4684	5	next	next	JJ
cord-015021-pol2qm74	4684	6	step	step	NN
cord-015021-pol2qm74	4684	7	of	of	IN
cord-015021-pol2qm74	4684	8	experiments	experiment	NNS
cord-015021-pol2qm74	4684	9	using	use	VBG
cord-015021-pol2qm74	4684	10	the	the	DT
cord-015021-pol2qm74	4684	11	same	same	JJ
cord-015021-pol2qm74	4684	12	model	model	NN
cord-015021-pol2qm74	4684	13	,	,	,
cord-015021-pol2qm74	4684	14	but	but	CC
cord-015021-pol2qm74	4684	15	after	after	IN
cord-015021-pol2qm74	4684	16	trauma	trauma	NN
cord-015021-pol2qm74	4684	17	.	.	.
cord-015021-pol2qm74	4685	1	These	these	DT
cord-015021-pol2qm74	4685	2	investigations	investigation	NNS
cord-015021-pol2qm74	4685	3	will	will	MD
cord-015021-pol2qm74	4685	4	let	let	VB
cord-015021-pol2qm74	4685	5	us	-PRON-	PRP
cord-015021-pol2qm74	4685	6	verify	verify	VB
cord-015021-pol2qm74	4685	7	the	the	DT
cord-015021-pol2qm74	4685	8	hypothesis	hypothesis	NN
cord-015021-pol2qm74	4685	9	that	that	IN
cord-015021-pol2qm74	4685	10	the	the	DT
cord-015021-pol2qm74	4685	11	protein	protein	NN
cord-015021-pol2qm74	4685	12	IL-2	IL-2	NNP
cord-015021-pol2qm74	4685	13	gene	gene	NN
cord-015021-pol2qm74	4685	14	trans	trans	NNP
cord-015021-pol2qm74	4685	15	-	-	NNS
cord-015021-pol2qm74	4685	16	factors	factor	NNS
cord-015021-pol2qm74	4685	17	may	may	MD
cord-015021-pol2qm74	4685	18	play	play	VB
cord-015021-pol2qm74	4685	19	a	a	DT
cord-015021-pol2qm74	4685	20	definite	definite	JJ
cord-015021-pol2qm74	4685	21	role	role	NN
cord-015021-pol2qm74	4685	22	in	in	IN
cord-015021-pol2qm74	4685	23	the	the	DT
cord-015021-pol2qm74	4685	24	decrease	decrease	NN
cord-015021-pol2qm74	4685	25	of	of	IN
cord-015021-pol2qm74	4685	26	the	the	DT
cord-015021-pol2qm74	4685	27	cell	cell	NN
cord-015021-pol2qm74	4685	28	immune	immune	NN
cord-015021-pol2qm74	4685	29	responce	responce	NN
cord-015021-pol2qm74	4685	30	after	after	IN
cord-015021-pol2qm74	4685	31	trauma	trauma	NN
cord-015021-pol2qm74	4685	32	.	.	.
cord-015021-pol2qm74	4686	1	Confronted	confront	VBN
cord-015021-pol2qm74	4686	2	with	with	IN
cord-015021-pol2qm74	4686	3	the	the	DT
cord-015021-pol2qm74	4686	4	routine	routine	JJ
cord-015021-pol2qm74	4686	5	procedure	procedure	NN
cord-015021-pol2qm74	4686	6	of	of	IN
cord-015021-pol2qm74	4686	7	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	4686	8	treatment	treatment	NN
cord-015021-pol2qm74	4686	9	of	of	IN
cord-015021-pol2qm74	4686	10	candidates	candidate	NNS
cord-015021-pol2qm74	4686	11	for	for	IN
cord-015021-pol2qm74	4686	12	surgery	surgery	NN
cord-015021-pol2qm74	4686	13	in	in	IN
cord-015021-pol2qm74	4686	14	a	a	DT
cord-015021-pol2qm74	4686	15	rural	rural	JJ
cord-015021-pol2qm74	4686	16	African	african	JJ
cord-015021-pol2qm74	4686	17	hospital	hospital	NN
cord-015021-pol2qm74	4686	18	,	,	,
cord-015021-pol2qm74	4686	19	we	-PRON-	PRP
cord-015021-pol2qm74	4686	20	initiated	initiate	VBD
cord-015021-pol2qm74	4686	21	studies	study	NNS
cord-015021-pol2qm74	4686	22	on	on	IN
cord-015021-pol2qm74	4686	23	the	the	DT
cord-015021-pol2qm74	4686	24	fre'Quency	fre'quency	NN
cord-015021-pol2qm74	4686	25	of	of	IN
cord-015021-pol2qm74	4686	26	post	post	JJ
cord-015021-pol2qm74	4686	27	-	-	JJ
cord-015021-pol2qm74	4686	28	surgical	surgical	JJ
cord-015021-pol2qm74	4686	29	malaria	malaria	NN
cord-015021-pol2qm74	4686	30	.	.	.
cord-015021-pol2qm74	4687	1	In	in	IN
cord-015021-pol2qm74	4687	2	Tanzania	Tanzania	NNP
cord-015021-pol2qm74	4687	3	195	195	CD
cord-015021-pol2qm74	4687	4	non	non	JJ
cord-015021-pol2qm74	4687	5	-	-	JJ
cord-015021-pol2qm74	4687	6	pregnant	pregnant	JJ
cord-015021-pol2qm74	4687	7	patients	patient	NNS
cord-015021-pol2qm74	4687	8	from	from	IN
cord-015021-pol2qm74	4687	9	rural	rural	JJ
cord-015021-pol2qm74	4687	10	areas	area	NNS
cord-015021-pol2qm74	4687	11	were	be	VBD
cord-015021-pol2qm74	4687	12	followed	follow	VBN
cord-015021-pol2qm74	4687	13	.	.	.
cord-015021-pol2qm74	4688	1	Of	of	IN
cord-015021-pol2qm74	4688	2	preoperative	preoperative	JJ
cord-015021-pol2qm74	4688	3	patients	patient	NNS
cord-015021-pol2qm74	4688	4	10	10	CD
cord-015021-pol2qm74	4688	5	%	%	NN
cord-015021-pol2qm74	4688	6	had	have	VBD
cord-015021-pol2qm74	4688	7	a	a	DT
cord-015021-pol2qm74	4688	8	parasitaemia	parasitaemia	NN
cord-015021-pol2qm74	4688	9	and	and	CC
cord-015021-pol2qm74	4688	10	those	those	DT
cord-015021-pol2qm74	4688	11	maintaining	maintain	VBG
cord-015021-pol2qm74	4688	12	it	-PRON-	PRP
cord-015021-pol2qm74	4688	13	showed	show	VBD
cord-015021-pol2qm74	4688	14	no	no	DT
cord-015021-pol2qm74	4688	15	increase	increase	NN
cord-015021-pol2qm74	4688	16	or	or	CC
cord-015021-pol2qm74	4688	17	complaints	complaint	NNS
cord-015021-pol2qm74	4688	18	.	.	.
cord-015021-pol2qm74	4689	1	Nine	nine	CD
cord-015021-pol2qm74	4689	2	percent	percent	NN
cord-015021-pol2qm74	4689	3	of	of	IN
cord-015021-pol2qm74	4689	4	patients	patient	NNS
cord-015021-pol2qm74	4689	5	without	without	IN
cord-015021-pol2qm74	4689	6	detectable	detectable	JJ
cord-015021-pol2qm74	4689	7	parasitaemia	parasitaemia	NN
cord-015021-pol2qm74	4689	8	before	before	IN
cord-015021-pol2qm74	4689	9	surgery	surgery	NN
cord-015021-pol2qm74	4689	10	came	come	VBD
cord-015021-pol2qm74	4689	11	down	down	RP
cord-015021-pol2qm74	4689	12	afterwards	afterwards	RB
cord-015021-pol2qm74	4689	13	and	and	CC
cord-015021-pol2qm74	4689	14	one	one	CD
cord-015021-pol2qm74	4689	15	-	-	HYPH
cord-015021-pol2qm74	4689	16	third	third	NN
cord-015021-pol2qm74	4689	17	had	have	VBD
cord-015021-pol2qm74	4689	18	malaria	malaria	NN
cord-015021-pol2qm74	4689	19	-	-	HYPH
cord-015021-pol2qm74	4689	20	like	like	JJ
cord-015021-pol2qm74	4689	21	complaints	complaint	NNS
cord-015021-pol2qm74	4689	22	.	.	.
cord-015021-pol2qm74	4690	1	Spinal	spinal	JJ
cord-015021-pol2qm74	4690	2	and	and	CC
cord-015021-pol2qm74	4690	3	general	general	JJ
cord-015021-pol2qm74	4690	4	anaesthesia	anaesthesia	NN
cord-015021-pol2qm74	4690	5	were	be	VBD
cord-015021-pol2qm74	4690	6	equally	equally	RB
cord-015021-pol2qm74	4690	7	applied	apply	VBN
cord-015021-pol2qm74	4690	8	in	in	IN
cord-015021-pol2qm74	4690	9	these	these	DT
cord-015021-pol2qm74	4690	10	last	last	JJ
cord-015021-pol2qm74	4690	11	patients	patient	NNS
cord-015021-pol2qm74	4690	12	.	.	.
cord-015021-pol2qm74	4691	1	In	in	IN
cord-015021-pol2qm74	4691	2	Burkina	Burkina	NNP
cord-015021-pol2qm74	4691	3	Faso	Faso	NNP
cord-015021-pol2qm74	4691	4	we	-PRON-	PRP
cord-015021-pol2qm74	4691	5	studied	study	VBD
cord-015021-pol2qm74	4691	6	120	120	CD
cord-015021-pol2qm74	4691	7	patients	patient	NNS
cord-015021-pol2qm74	4691	8	of	of	IN
cord-015021-pol2qm74	4691	9	which	which	WDT
cord-015021-pol2qm74	4691	10	16	16	CD
cord-015021-pol2qm74	4691	11	%	%	NN
cord-015021-pol2qm74	4691	12	had	have	VBD
cord-015021-pol2qm74	4691	13	a	a	DT
cord-015021-pol2qm74	4691	14	parasitaemia	parasitaemia	NN
cord-015021-pol2qm74	4691	15	on	on	IN
cord-015021-pol2qm74	4691	16	admission	admission	NN
cord-015021-pol2qm74	4691	17	and	and	CC
cord-015021-pol2qm74	4691	18	6	6	CD
cord-015021-pol2qm74	4691	19	%	%	NN
cord-015021-pol2qm74	4691	20	had	have	VBD
cord-015021-pol2qm74	4691	21	postoperative	postoperative	JJ
cord-015021-pol2qm74	4691	22	malaria	malaria	NN
cord-015021-pol2qm74	4691	23	.	.	.
cord-015021-pol2qm74	4692	1	Half	half	NN
cord-015021-pol2qm74	4692	2	of	of	IN
cord-015021-pol2qm74	4692	3	the	the	DT
cord-015021-pol2qm74	4692	4	surgical	surgical	JJ
cord-015021-pol2qm74	4692	5	patients	patient	NNS
cord-015021-pol2qm74	4692	6	came	come	VBD
cord-015021-pol2qm74	4692	7	from	from	IN
cord-015021-pol2qm74	4692	8	rural	rural	JJ
cord-015021-pol2qm74	4692	9	areas	area	NNS
cord-015021-pol2qm74	4692	10	,	,	,
cord-015021-pol2qm74	4692	11	whilst	whilst	IN
cord-015021-pol2qm74	4692	12	only	only	RB
cord-015021-pol2qm74	4692	13	14	14	CD
cord-015021-pol2qm74	4692	14	%	%	NN
cord-015021-pol2qm74	4692	15	of	of	IN
cord-015021-pol2qm74	4692	16	those	those	DT
cord-015021-pol2qm74	4692	17	with	with	IN
cord-015021-pol2qm74	4692	18	malaria	malaria	NN
cord-015021-pol2qm74	4692	19	lived	live	VBD
cord-015021-pol2qm74	4692	20	in	in	IN
cord-015021-pol2qm74	4692	21	the	the	DT
cord-015021-pol2qm74	4692	22	city	city	NN
cord-015021-pol2qm74	4692	23	(	(	-LRB-
cord-015021-pol2qm74	4692	24	with	with	IN
cord-015021-pol2qm74	4692	25	much	much	RB
cord-015021-pol2qm74	4692	26	less	less	JJR
cord-015021-pol2qm74	4692	27	exposure	exposure	NN
cord-015021-pol2qm74	4692	28	and	and	CC
cord-015021-pol2qm74	4692	29	immunity	immunity	NN
cord-015021-pol2qm74	4692	30	)	)	-RRB-
cord-015021-pol2qm74	4692	31	.	.	.
cord-015021-pol2qm74	4693	1	57	57	CD
cord-015021-pol2qm74	4693	2	%	%	NN
cord-015021-pol2qm74	4693	3	underwent	undergo	VBD
cord-015021-pol2qm74	4693	4	major	major	JJ
cord-015021-pol2qm74	4693	5	surgery	surgery	NN
cord-015021-pol2qm74	4693	6	and	and	CC
cord-015021-pol2qm74	4693	7	43	43	CD
cord-015021-pol2qm74	4693	8	%	%	NN
cord-015021-pol2qm74	4693	9	minor	minor	NN
cord-015021-pol2qm74	4693	10	.	.	.
cord-015021-pol2qm74	4694	1	Bloodtransfusions	bloodtransfusion	NNS
cord-015021-pol2qm74	4694	2	(	(	-LRB-
cord-015021-pol2qm74	4694	3	4	4	CD
cord-015021-pol2qm74	4694	4	%	%	NN
cord-015021-pol2qm74	4694	5	with	with	IN
cord-015021-pol2qm74	4694	6	parasites	parasite	NNS
cord-015021-pol2qm74	4694	7	)	)	-RRB-
cord-015021-pol2qm74	4694	8	never	never	RB
cord-015021-pol2qm74	4694	9	evoked	evoke	VBD
cord-015021-pol2qm74	4694	10	a	a	DT
cord-015021-pol2qm74	4694	11	parasitaemia	parasitaemia	NN
cord-015021-pol2qm74	4694	12	in	in	IN
cord-015021-pol2qm74	4694	13	recipients	recipient	NNS
cord-015021-pol2qm74	4694	14	.	.	.
cord-015021-pol2qm74	4695	1	Post	post	JJ
cord-015021-pol2qm74	4695	2	-	-	JJ
cord-015021-pol2qm74	4695	3	surgical	surgical	JJ
cord-015021-pol2qm74	4695	4	malaria	malaria	NN
cord-015021-pol2qm74	4695	5	is	be	VBZ
cord-015021-pol2qm74	4695	6	thus	thus	RB
cord-015021-pol2qm74	4695	7	a	a	DT
cord-015021-pol2qm74	4695	8	reality	reality	NN
cord-015021-pol2qm74	4695	9	in	in	IN
cord-015021-pol2qm74	4695	10	about	about	RB
cord-015021-pol2qm74	4695	11	10	10	CD
cord-015021-pol2qm74	4695	12	%	%	NN
cord-015021-pol2qm74	4695	13	of	of	IN
cord-015021-pol2qm74	4695	14	the	the	DT
cord-015021-pol2qm74	4695	15	adult	adult	NN
cord-015021-pol2qm74	4695	16	cases	case	NNS
cord-015021-pol2qm74	4695	17	,	,	,
cord-015021-pol2qm74	4695	18	both	both	CC
cord-015021-pol2qm74	4695	19	in	in	IN
cord-015021-pol2qm74	4695	20	East	East	NNP
cord-015021-pol2qm74	4695	21	and	and	CC
cord-015021-pol2qm74	4695	22	West	West	NNP
cord-015021-pol2qm74	4695	23	Africa	Africa	NNP
cord-015021-pol2qm74	4695	24	.	.	.
cord-015021-pol2qm74	4696	1	Surgery	surgery	NN
cord-015021-pol2qm74	4696	2	evokes	evoke	VBZ
cord-015021-pol2qm74	4696	3	a	a	DT
cord-015021-pol2qm74	4696	4	cascade	cascade	NN
cord-015021-pol2qm74	4696	5	of	of	IN
cord-015021-pol2qm74	4696	6	factors	factor	NNS
cord-015021-pol2qm74	4696	7	,	,	,
cord-015021-pol2qm74	4696	8	varying	vary	VBG
cord-015021-pol2qm74	4696	9	from	from	IN
cord-015021-pol2qm74	4696	10	cortison	cortison	NNP
cord-015021-pol2qm74	4696	11	to	to	IN
cord-015021-pol2qm74	4696	12	interleukines	interleukines	NNP
cord-015021-pol2qm74	4696	13	and	and	CC
cord-015021-pol2qm74	4696	14	acute	acute	JJ
cord-015021-pol2qm74	4696	15	phase	phase	NN
cord-015021-pol2qm74	4696	16	proteins	protein	NNS
cord-015021-pol2qm74	4696	17	;	;	:
cord-015021-pol2qm74	4696	18	immune	immune	JJ
cord-015021-pol2qm74	4696	19	responses	response	NNS
cord-015021-pol2qm74	4696	20	may	may	MD
cord-015021-pol2qm74	4696	21	temporarily	temporarily	RB
cord-015021-pol2qm74	4696	22	be	be	VB
cord-015021-pol2qm74	4696	23	suppressed	suppress	VBN
cord-015021-pol2qm74	4696	24	.	.	.
cord-015021-pol2qm74	4697	1	Clinical	clinical	JJ
cord-015021-pol2qm74	4697	2	attacks	attack	NNS
cord-015021-pol2qm74	4697	3	of	of	IN
cord-015021-pol2qm74	4697	4	malaria	malaria	NN
cord-015021-pol2qm74	4697	5	in	in	IN
cord-015021-pol2qm74	4697	6	otherwise	otherwise	RB
cord-015021-pol2qm74	4697	7	immunes	immune	NNS
cord-015021-pol2qm74	4697	8	could	could	MD
cord-015021-pol2qm74	4697	9	be	be	VB
cord-015021-pol2qm74	4697	10	evoked	evoke	VBN
cord-015021-pol2qm74	4697	11	by	by	IN
cord-015021-pol2qm74	4697	12	one	one	CD
cord-015021-pol2qm74	4697	13	of	of	IN
cord-015021-pol2qm74	4697	14	these	these	DT
cord-015021-pol2qm74	4697	15	factors	factor	NNS
cord-015021-pol2qm74	4697	16	.	.	.
cord-015021-pol2qm74	4698	1	Though	though	IN
cord-015021-pol2qm74	4698	2	malaria	malaria	NN
cord-015021-pol2qm74	4698	3	can	can	MD
cord-015021-pol2qm74	4698	4	easily	easily	RB
cord-015021-pol2qm74	4698	5	be	be	VB
cord-015021-pol2qm74	4698	6	cured	cure	VBN
cord-015021-pol2qm74	4698	7	,	,	,
cord-015021-pol2qm74	4698	8	the	the	DT
cord-015021-pol2qm74	4698	9	differential	differential	JJ
cord-015021-pol2qm74	4698	10	diagnosis	diagnosis	NN
cord-015021-pol2qm74	4698	11	is	be	VBZ
cord-015021-pol2qm74	4698	12	difficult	difficult	JJ
cord-015021-pol2qm74	4698	13	because	because	IN
cord-015021-pol2qm74	4698	14	of	of	IN
cord-015021-pol2qm74	4698	15	post	post	JJ
cord-015021-pol2qm74	4698	16	-	-	JJ
cord-015021-pol2qm74	4698	17	surgery	surgery	JJ
cord-015021-pol2qm74	4698	18	fevers	fever	NNS
cord-015021-pol2qm74	4698	19	;	;	:
cord-015021-pol2qm74	4698	20	we	-PRON-	PRP
cord-015021-pol2qm74	4698	21	found	find	VBD
cord-015021-pol2qm74	4698	22	that	that	IN
cord-015021-pol2qm74	4698	23	16	16	CD
cord-015021-pol2qm74	4698	24	%	%	NN
cord-015021-pol2qm74	4698	25	was	be	VBD
cord-015021-pol2qm74	4698	26	treated	treat	VBN
cord-015021-pol2qm74	4698	27	without	without	IN
cord-015021-pol2qm74	4698	28	justified	justified	JJ
cord-015021-pol2qm74	4698	29	indication	indication	NN
cord-015021-pol2qm74	4698	30	.	.	.
cord-015021-pol2qm74	4699	1	The	the	DT
cord-015021-pol2qm74	4699	2	involvement	involvement	NN
cord-015021-pol2qm74	4699	3	of	of	IN
cord-015021-pol2qm74	4699	4	"	"	``
cord-015021-pol2qm74	4699	5	student	student	NN
cord-015021-pol2qm74	4699	6	-	-	HYPH
cord-015021-pol2qm74	4699	7	doctors	doctor	NNS
cord-015021-pol2qm74	4699	8	"	"	''
cord-015021-pol2qm74	4699	9	A.	a.	NN
cord-015021-pol2qm74	4700	1	This	this	DT
cord-015021-pol2qm74	4700	2	study	study	NN
cord-015021-pol2qm74	4700	3	examines	examine	VBZ
cord-015021-pol2qm74	4700	4	glucose	glucose	NN
cord-015021-pol2qm74	4700	5	uptake	uptake	NN
cord-015021-pol2qm74	4700	6	and	and	CC
cord-015021-pol2qm74	4700	7	hexose	hexose	NN
cord-015021-pol2qm74	4700	8	monophosphate	monophosphate	NN
cord-015021-pol2qm74	4700	9	(	(	-LRB-
cord-015021-pol2qm74	4700	10	I	i	NN
cord-015021-pol2qm74	4700	11	~	~	NFP
cord-015021-pol2qm74	4700	12	IP	ip	NN
cord-015021-pol2qm74	4700	13	)	)	-RRB-
cord-015021-pol2qm74	4700	14	shunt	shunt	NN
cord-015021-pol2qm74	4700	15	activity	activity	NN
cord-015021-pol2qm74	4700	16	in	in	IN
cord-015021-pol2qm74	4700	17	normal	normal	JJ
cord-015021-pol2qm74	4700	18	human	human	JJ
cord-015021-pol2qm74	4700	19	peripheral	peripheral	JJ
cord-015021-pol2qm74	4700	20	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	4700	21	and	and	CC
cord-015021-pol2qm74	4700	22	polymorphonuclear	polymorphonuclear	NN
cord-015021-pol2qm74	4700	23	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	4700	24	(	(	-LRB-
cord-015021-pol2qm74	4700	25	PMN	PMN	NNP
cord-015021-pol2qm74	4700	26	)	)	-RRB-
cord-015021-pol2qm74	4700	27	.	.	.
cord-015021-pol2qm74	4701	1	Glucose	glucose	NN
cord-015021-pol2qm74	4701	2	uptake	uptake	NN
cord-015021-pol2qm74	4701	3	was	be	VBD
cord-015021-pol2qm74	4701	4	determined	determine	VBN
cord-015021-pol2qm74	4701	5	by	by	IN
cord-015021-pol2qm74	4701	6	measurir	measurir	NNP
cord-015021-pol2qm74	4701	7	,	,	,
cord-015021-pol2qm74	4701	8	g	g	NNP
cord-015021-pol2qm74	4701	9	the	the	DT
cord-015021-pol2qm74	4701	10	uptake	uptake	NN
cord-015021-pol2qm74	4701	11	of	of	IN
cord-015021-pol2qm74	4701	12	tritiated	tritiated	NNP
cord-015021-pol2qm74	4701	13	deoxyglucose	deoxyglucose	NNP
cord-015021-pol2qm74	4701	14	,	,	,
cord-015021-pol2qm74	4701	15	a	a	DT
cord-015021-pol2qm74	4701	16	non	non	JJ
cord-015021-pol2qm74	4701	17	-	-	JJ
cord-015021-pol2qm74	4701	18	metabolized	metabolized	JJ
cord-015021-pol2qm74	4701	19	glucose	glucose	NN
cord-015021-pol2qm74	4701	20	analogue	analogue	NN
cord-015021-pol2qm74	4701	21	.	.	.
cord-015021-pol2qm74	4702	1	Adsorption	Adsorption	NNP
cord-015021-pol2qm74	4702	2	of	of	IN
cord-015021-pol2qm74	4702	3	CO2	CO2	NNP
cord-015021-pol2qm74	4702	4	derived	derive	VBN
cord-015021-pol2qm74	4702	5	from	from	IN
cord-015021-pol2qm74	4702	6	[	[	-LRB-
cord-015021-pol2qm74	4702	7	I-14C	i-14c	NN
cord-015021-pol2qm74	4702	8	]	]	-RRB-
cord-015021-pol2qm74	4702	9	glucose	glucose	NN
cord-015021-pol2qm74	4702	10	was	be	VBD
cord-015021-pol2qm74	4702	11	used	use	VBN
cord-015021-pol2qm74	4702	12	to	to	TO
cord-015021-pol2qm74	4702	13	determine	determine	VB
cord-015021-pol2qm74	4702	14	kNP	kNP	NNP
cord-015021-pol2qm74	4702	15	shunt	shunt	VB
cord-015021-pol2qm74	4702	16	activity	activity	NN
cord-015021-pol2qm74	4702	17	.	.	.
cord-015021-pol2qm74	4703	1	In	in	IN
cord-015021-pol2qm74	4703	2	vitro	vitro	FW
cord-015021-pol2qm74	4703	3	assays	assay	NNS
cord-015021-pol2qm74	4703	4	were	be	VBD
cord-015021-pol2qm74	4703	5	carried	carry	VBN
cord-015021-pol2qm74	4703	6	out	out	RP
cord-015021-pol2qm74	4703	7	in	in	IN
cord-015021-pol2qm74	4703	8	hormone	hormone	NN
cord-015021-pol2qm74	4703	9	concentrations	concentration	NNS
cord-015021-pol2qm74	4703	10	approximating	approximate	VBG
cord-015021-pol2qm74	4703	11	normal	normal	JJ
cord-015021-pol2qm74	4703	12	and	and	CC
cord-015021-pol2qm74	4703	13	elevated	elevated	JJ
cord-015021-pol2qm74	4703	14	trauma	trauma	NN
cord-015021-pol2qm74	4703	15	blood	blood	NN
cord-015021-pol2qm74	4703	16	levels	level	NNS
cord-015021-pol2qm74	4703	17	.	.	.
cord-015021-pol2qm74	4704	1	(	(	-LRB-
cord-015021-pol2qm74	4704	2	Normal	normal	JJ
cord-015021-pol2qm74	4704	3	-cortisol	-cortisol	NNP
cord-015021-pol2qm74	4704	4	0.12	0.12	CD
cord-015021-pol2qm74	4705	1	~g	~g	NNP
cord-015021-pol2qm74	4706	1	/ml	/ml	NFP
cord-015021-pol2qm74	4706	2	,	,	,
cord-015021-pol2qm74	4707	1	glucagon	glucagon	NN
cord-015021-pol2qm74	4707	2	80	80	CD
cord-015021-pol2qm74	4707	3	#	#	$
cord-015021-pol2qm74	4707	4	g	g	NN
cord-015021-pol2qm74	4707	5	/	/	SYM
cord-015021-pol2qm74	4707	6	m1	m1	NNP
cord-015021-pol2qm74	4707	7	,	,	,
cord-015021-pol2qm74	4707	8	epinephrine	epinephrine	NN
cord-015021-pol2qm74	4707	9	20	20	CD
cord-015021-pol2qm74	4708	1	~g	~g	NNP
cord-015021-pol2qm74	4708	2	/	/	SYM
cord-015021-pol2qm74	4708	3	ml	ml	NN
cord-015021-pol2qm74	4708	4	,	,	,
cord-015021-pol2qm74	4708	5	insulin	insulin	NN
cord-015021-pol2qm74	4708	6	18	18	CD
cord-015021-pol2qm74	4708	7	t	t	NN
cord-015021-pol2qm74	4709	1	~U	~U	NFP
cord-015021-pol2qm74	4709	2	/	/	SYM
cord-015021-pol2qm74	4709	3	ml	ml	XX
cord-015021-pol2qm74	4709	4	;	;	:
cord-015021-pol2qm74	4709	5	Traumaeortisol	Traumaeortisol	NNP
cord-015021-pol2qm74	4709	6	0.40	0.40	CD
cord-015021-pol2qm74	4710	1	~g	~g	NNP
cord-015021-pol2qm74	4710	2	/	/	SYM
cord-015021-pol2qm74	4710	3	ml	ml	XX
cord-015021-pol2qm74	4710	4	,	,	,
cord-015021-pol2qm74	4711	1	glucagon	glucagon	NNP
cord-015021-pol2qm74	4712	1	500	500	CD
cord-015021-pol2qm74	4712	2	/*g	/*g	NN
cord-015021-pol2qm74	4712	3	/	/	SYM
cord-015021-pol2qm74	4712	4	ml	ml	NN
cord-015021-pol2qm74	4712	5	,	,	,
cord-015021-pol2qm74	4712	6	epinephrine	epinephrine	NN
cord-015021-pol2qm74	4712	7	420~g	420~g	CD
cord-015021-pol2qm74	4712	8	/	/	SYM
cord-015021-pol2qm74	4712	9	ml	ml	NN
cord-015021-pol2qm74	4712	10	,	,	,
cord-015021-pol2qm74	4712	11	insulin	insulin	NN
cord-015021-pol2qm74	4712	12	36	36	CD
cord-015021-pol2qm74	4713	1	~IJ	~ij	LS
cord-015021-pol2qm74	4713	2	/	/	SYM
cord-015021-pol2qm74	4713	3	ml	ml	NN
cord-015021-pol2qm74	4713	4	.	.	.
cord-015021-pol2qm74	4714	1	Analysis	analysis	NN
cord-015021-pol2qm74	4714	2	of	of	IN
cord-015021-pol2qm74	4714	3	twenty	twenty	CD
cord-015021-pol2qm74	4714	4	subjects	subject	NNS
cord-015021-pol2qm74	4714	5	showed	show	VBD
cord-015021-pol2qm74	4714	6	a	a	DT
cord-015021-pol2qm74	4714	7	reduction	reduction	NN
cord-015021-pol2qm74	4714	8	of	of	IN
cord-015021-pol2qm74	4714	9	207	207	CD
cord-015021-pol2qm74	4714	10	°	°	NN
cord-015021-pol2qm74	4714	11	~MP	~MP	.
cord-015021-pol2qm74	4715	1	shunt	shunt	NN
cord-015021-pol2qm74	4715	2	activity	activity	NN
cord-015021-pol2qm74	4715	3	by	by	IN
cord-015021-pol2qm74	4715	4	lymphoeytes	lymphoeytes	NNP
cord-015021-pol2qm74	4715	5	and	and	CC
cord-015021-pol2qm74	4715	6	a	a	LS
cord-015021-pol2qm74	4715	7	]	]	-RRB-
cord-015021-pol2qm74	4715	8	3	3	CD
cord-015021-pol2qm74	4715	9	%	%	NN
cord-015021-pol2qm74	4715	10	reduction	reduction	NN
cord-015021-pol2qm74	4715	11	in	in	IN
cord-015021-pol2qm74	4715	12	glucose	glucose	NN
cord-015021-pol2qm74	4715	13	uptake	uptake	NN
cord-015021-pol2qm74	4715	14	by	by	IN
cord-015021-pol2qm74	4715	15	P	p	NN
cord-015021-pol2qm74	4716	1	~N	~N	NFP
cord-015021-pol2qm74	4716	2	in	in	IN
cord-015021-pol2qm74	4716	3	normal	normal	JJ
cord-015021-pol2qm74	4716	4	vs.	vs.	IN
cord-015021-pol2qm74	4716	5	trauma	trauma	NN
cord-015021-pol2qm74	4716	6	honTc	honTc	NNP
cord-015021-pol2qm74	4716	7	,	,	,
cord-015021-pol2qm74	4716	8	nes	nes	NNP
cord-015021-pol2qm74	4716	9	p	p	NNP
cord-015021-pol2qm74	4716	10	<	<	NNP
cord-015021-pol2qm74	4716	11	0.05	0.05	CD
cord-015021-pol2qm74	4716	12	.	.	.
cord-015021-pol2qm74	4717	1	Lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	4717	2	glucose	glucose	NN
cord-015021-pol2qm74	4717	3	uptake	uptake	NN
cord-015021-pol2qm74	4717	4	was	be	VBD
cord-015021-pol2qm74	4717	5	also	also	RB
cord-015021-pol2qm74	4717	6	reduced	reduce	VBN
cord-015021-pol2qm74	4717	7	by	by	IN
cord-015021-pol2qm74	4717	8	trauma	trauma	NN
cord-015021-pol2qm74	4717	9	hormones	hormone	NNS
cord-015021-pol2qm74	4717	10	p~0.05	p~0.05	NNP
cord-015021-pol2qm74	4717	11	.	.	.
cord-015021-pol2qm74	4718	1	It	-PRON-	PRP
cord-015021-pol2qm74	4718	2	ha~	ha~	VBD
cord-015021-pol2qm74	4718	3	be.ea~	be.ea~	NNP
cord-015021-pol2qm74	4718	4	suggested	suggest	VBD
cord-015021-pol2qm74	4718	5	thgt	thgt	NNP
cord-015021-pol2qm74	4718	6	idiopatNo	idiopatNo	NNP
cord-015021-pol2qm74	4718	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4718	8	fibrous	fibrous	NN
cord-015021-pol2qm74	4718	9	(	(	-LRB-
cord-015021-pol2qm74	4718	10	Y.PF	Y.PF	NNP
cord-015021-pol2qm74	4718	11	)	)	-RRB-
cord-015021-pol2qm74	4718	12	[	[	-LRB-
cord-015021-pol2qm74	4718	13	s	s	VBZ
cord-015021-pol2qm74	4718	14	a	a	DT
cord-015021-pol2qm74	4718	15	consequence	consequence	NN
cord-015021-pol2qm74	4718	16	of	of	IN
cord-015021-pol2qm74	4718	17	severe	severe	JJ
cord-015021-pol2qm74	4718	18	alveolar	alveolar	JJ
cord-015021-pol2qm74	4718	19	epithelial	epithelial	JJ
cord-015021-pol2qm74	4718	20	injury	injury	NN
cord-015021-pol2qm74	4718	21	and	and	CC
cord-015021-pol2qm74	4718	22	is	be	VBZ
cord-015021-pol2qm74	4718	23	associated	associate	VBN
cord-015021-pol2qm74	4718	24	with	with	IN
cord-015021-pol2qm74	4718	25	an	an	DT
cord-015021-pol2qm74	4718	26	Nveolar	Nveolar	NNP
cord-015021-pol2qm74	4718	27	irNammamry	irNammamry	NNPS
cord-015021-pol2qm74	4718	28	reactio~	reactio~	NNS
cord-015021-pol2qm74	4718	29	and	and	CC
cord-015021-pol2qm74	4718	30	the	the	DT
cord-015021-pol2qm74	4718	31	presence	presence	NN
cord-015021-pol2qm74	4718	32	0f.neutr0phils	0f.neutr0phils	CD
cord-015021-pol2qm74	4718	33	.	.	.
cord-015021-pol2qm74	4719	1	There	there	RB
cord-015021-pol2qm74	4719	2	~	~	NFP
cord-015021-pol2qm74	4719	3	bre	bre	NNP
cord-015021-pol2qm74	4719	4	,	,	,
cord-015021-pol2qm74	4719	5	neutr0pk~	neutr0pk~	NNP
cord-015021-pol2qm74	4719	6	chemoattra	chemoattra	NNP
cord-015021-pol2qm74	4719	7	~	~	NFP
cord-015021-pol2qm74	4719	8	ant~	ant~	NNP
cord-015021-pol2qm74	4719	9	are	be	VBP
cord-015021-pol2qm74	4719	10	probably	probably	RB
cord-015021-pol2qm74	4719	11	important	important	JJ
cord-015021-pol2qm74	4719	12	in	in	IN
cord-015021-pol2qm74	4719	13	the	the	DT
cord-015021-pol2qm74	4719	14	genegs	genegs	NNP
cord-015021-pol2qm74	4719	15	oft.he	oft.he	NNP
cord-015021-pol2qm74	4719	16	iNfial	iNfial	NNP
cord-015021-pol2qm74	4719	17	lesions	lesion	NNS
cord-015021-pol2qm74	4719	18	of	of	IN
cord-015021-pol2qm74	4719	19	IPF	IPF	NNP
cord-015021-pol2qm74	4719	20	.	.	.
cord-015021-pol2qm74	4720	1	The	the	DT
cord-015021-pol2qm74	4720	2	obse,"wSon	obse,"wSon	NNP
cord-015021-pol2qm74	4720	3	that	that	WDT
cord-015021-pol2qm74	4720	4	stimulated	stimulate	VBD
cord-015021-pol2qm74	4720	5	macrophages	macrophage	NNS
cord-015021-pol2qm74	4720	6	are	be	VBP
cord-015021-pol2qm74	4720	7	oR	or	CC
cord-015021-pol2qm74	4720	8	~	~	NFP
cord-015021-pol2qm74	4720	9	n	n	XX
cord-015021-pol2qm74	4720	10	histologically	histologically	RB
cord-015021-pol2qm74	4720	11	promin	promin	NNP
cord-015021-pol2qm74	4721	1	~t	~t	JJ
cord-015021-pol2qm74	4721	2	in	in	IN
cord-015021-pol2qm74	4721	3	fibmfio	fibmfio	FW
cord-015021-pol2qm74	4721	4	[	[	-LRB-
cord-015021-pol2qm74	4721	5	-~gs	-~gs	NFP
cord-015021-pol2qm74	4721	6	~.nd	~.nd	NNP
cord-015021-pol2qm74	4721	7	am	be	VBP
cord-015021-pol2qm74	4721	8	capable	capable	JJ
cord-015021-pol2qm74	4721	9	of	of	IN
cord-015021-pol2qm74	4721	10	p	p	NN
cord-015021-pol2qm74	4721	11	~	~	CD
cord-015021-pol2qm74	4721	12	oducmg	oducmg	NNP
cord-015021-pol2qm74	4721	13	a	a	DT
cord-015021-pol2qm74	4721	14	v	v	NN
cord-015021-pol2qm74	4722	1	~dery	~dery	NNP
cord-015021-pol2qm74	4722	2	0f	0f	NFP
cord-015021-pol2qm74	4722	3	flbrogenic	flbrogenic	NNP
cord-015021-pol2qm74	4722	4	pep'ides	pep'ides	NNP
cord-015021-pol2qm74	4722	5	also	also	RB
cord-015021-pol2qm74	4722	6	a	a	LS
cord-015021-pol2qm74	4722	7	~	~	NFP
cord-015021-pol2qm74	4722	8	gues	gue	NNS
cord-015021-pol2qm74	4722	9	for	for	IN
cord-015021-pol2qm74	4722	10	their	-PRON-	PRP$
cord-015021-pol2qm74	4722	11	role	role	NN
cord-015021-pol2qm74	4722	12	~n	~n	NNP
cord-015021-pol2qm74	4723	1	the	the	DT
cord-015021-pol2qm74	4723	2	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	4723	3	prc~	prc~	CD
cord-015021-pol2qm74	4724	1	e~	e~	NFP
cord-015021-pol2qm74	4724	2	oflPF	oflpf	NN
cord-015021-pol2qm74	4724	3	.	.	.
cord-015021-pol2qm74	4725	1	The	the	DT
cord-015021-pol2qm74	4725	2	observation	observation	NN
cord-015021-pol2qm74	4725	3	that	that	IN
cord-015021-pol2qm74	4725	4	stimuMe~	stimuMe~	NNP
cord-015021-pol2qm74	4725	5	maerophages	maerophage	NNS
cord-015021-pol2qm74	4725	6	ere	ere	VBP
cord-015021-pol2qm74	4725	7	often	often	RB
cord-015021-pol2qm74	4725	8	histologica[Iy	histologica[iy	VBP
cord-015021-pol2qm74	4725	9	prominent	prominent	JJ
cord-015021-pol2qm74	4725	10	in	in	IN
cord-015021-pol2qm74	4725	11	fibrotio	fibrotio	NNP
cord-015021-pol2qm74	4725	12	lungs	lung	NNS
cord-015021-pol2qm74	4725	13	and	and	CC
cord-015021-pol2qm74	4725	14	~re	~re	NN
cord-015021-pol2qm74	4725	15	~pable	~pable	XX
cord-015021-pol2qm74	4725	16	of	of	IN
cord-015021-pol2qm74	4725	17	producing	produce	VBG
cord-015021-pol2qm74	4725	18	a	a	DT
cord-015021-pol2qm74	4725	19	varie~	varie~	NN
cord-015021-pol2qm74	4725	20	,	,	,
cord-015021-pol2qm74	4725	21	offibroge.~e	offibroge.~e	NN
cord-015021-pol2qm74	4725	22	peptide~	peptide~	,
cord-015021-pol2qm74	4725	23	also	also	RB
cord-015021-pol2qm74	4725	24	argues	argue	VBZ
cord-015021-pol2qm74	4725	25	for	for	IN
cord-015021-pol2qm74	4725	26	tkek	tkek	NNP
cord-015021-pol2qm74	4725	27	role	role	NN
cord-015021-pol2qm74	4725	28	in	in	IN
cord-015021-pol2qm74	4725	29	the	the	DT
cord-015021-pol2qm74	4725	30	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	4725	31	process	process	NN
cord-015021-pol2qm74	4725	32	,	,	,
cord-015021-pol2qm74	4725	33	Therefore	therefore	RB
cord-015021-pol2qm74	4725	34	,	,	,
cord-015021-pol2qm74	4725	35	we	-PRON-	PRP
cord-015021-pol2qm74	4725	36	ha-~e	ha-~e	RB
cord-015021-pol2qm74	4725	37	tested	test	VBD
cord-015021-pol2qm74	4725	38	the	the	DT
cord-015021-pol2qm74	4725	39	potentN	potentN	NNP
cord-015021-pol2qm74	4725	40	for	for	IN
cord-015021-pol2qm74	4725	41	iater!eukln-8	iater!eukln-8	NNP
cord-015021-pol2qm74	4726	1	(	(	-LRB-
cord-015021-pol2qm74	4726	2	I1	i1	NN
cord-015021-pol2qm74	4726	3	..	..	.
cord-015021-pol2qm74	4726	4	-8	-8	NNP
cord-015021-pol2qm74	4726	5	)	)	-RRB-
cord-015021-pol2qm74	4726	6	and	and	CC
cord-015021-pol2qm74	4726	7	mo	mo	NNP
cord-015021-pol2qm74	4726	8	~	~	NNP
cord-015021-pol2qm74	4726	9	tocyte	tocyte	NNP
cord-015021-pol2qm74	4726	10	chemotacde	chemotacde	NNP
cord-015021-pol2qm74	4726	11	pop	pop	NNP
cord-015021-pol2qm74	4726	12	,	,	,
cord-015021-pol2qm74	4726	13	de	de	NNP
cord-015021-pol2qm74	4726	14	1	1	CD
cord-015021-pol2qm74	4726	15	(	(	-LRB-
cord-015021-pol2qm74	4726	16	X¢CP-1	X¢CP-1	NNP
cord-015021-pol2qm74	4726	17	)	)	-RRB-
cord-015021-pol2qm74	4727	1	to	to	TO
cord-015021-pol2qm74	4727	2	induce	induce	VB
cord-015021-pol2qm74	4727	3	neutro	neutro	NNP
cord-015021-pol2qm74	4727	4	~	~	NFP
cord-015021-pol2qm74	4727	5	hil	hil	NNP
cord-015021-pol2qm74	4728	1	~d	~d	NNP
cord-015021-pol2qm74	4728	2	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	4729	1	phagocyte	phagocyte	NNP
cord-015021-pol2qm74	4729	2	accumuhdon	accumuhdon	NNP
cord-015021-pol2qm74	4729	3	in	in	IN
cord-015021-pol2qm74	4729	4	lungs	lung	NNS
cord-015021-pol2qm74	4729	5	of	of	IN
cord-015021-pol2qm74	4729	6	pafient~	pafient~	NNP
cord-015021-pol2qm74	4729	7	with	with	IN
cord-015021-pol2qm74	4729	8	pulmonary	pulmonary	NN
cord-015021-pol2qm74	4729	9	.~r	.~r	.
cord-015021-pol2qm74	4730	1	~idosis	~idosis	XX
cord-015021-pol2qm74	4730	2	and	and	CC
cord-015021-pol2qm74	4730	3	I	i	NN
cord-015021-pol2qm74	4730	4	~	~	NFP
cord-015021-pol2qm74	4730	5	F.	F.	NNP
cord-015021-pol2qm74	4730	6	Brenet	Brenet	NNP
cord-015021-pol2qm74	4730	7	~	~	NFP
cord-015021-pol2qm74	4730	8	o.alveolar	o.alveolar	CD
cord-015021-pol2qm74	4730	9	lavabo	lavabo	NN
cord-015021-pol2qm74	4730	10	(	(	-LRB-
cord-015021-pol2qm74	4730	11	BAL	BAL	NNP
cord-015021-pol2qm74	4730	12	)	)	-RRB-
cord-015021-pol2qm74	4730	13	fluids	fluid	VBZ
cord-015021-pol2qm74	4730	14	from	from	IN
cord-015021-pol2qm74	4730	15	12	12	CD
cord-015021-pol2qm74	4730	16	IPF	IPF	NNP
cord-015021-pol2qm74	4730	17	and	and	CC
cord-015021-pol2qm74	4730	18	15	15	CD
cord-015021-pol2qm74	4730	19	sar	sar	NN
cord-015021-pol2qm74	4731	1	~Qidosis	~qidosis	CD
cord-015021-pol2qm74	4731	2	patient	patient	NN
cord-015021-pol2qm74	4731	3	were	be	VBD
cord-015021-pol2qm74	4731	4	conexntrateA	conexntrateA	NNP
cord-015021-pol2qm74	4731	5	by	by	IN
cord-015021-pol2qm74	4731	6	reversed	reverse	VBN
cord-015021-pol2qm74	4731	7	-	-	HYPH
cord-015021-pol2qm74	4731	8	phase	phase	NN
cord-015021-pol2qm74	4731	9	chromatography	chromatography	NN
cord-015021-pol2qm74	4731	10	,	,	,
cord-015021-pol2qm74	4731	11	~d	~d	ADD
cord-015021-pol2qm74	4732	1	II.4	ii.4	XX
cord-015021-pol2qm74	4733	1	arid	arid	NNP
cord-015021-pol2qm74	4733	2	MCP-	MCP-	NNP
cord-015021-pol2qm74	4734	1	I	-PRON-	PRP
cord-015021-pol2qm74	4735	1	asso.~ed	asso.~ed	NNP
cord-015021-pol2qm74	4735	2	by	by	IN
cord-015021-pol2qm74	4735	3	ELLS	ELLS	NNP
cord-015021-pol2qm74	4735	4	&	&	CC
cord-015021-pol2qm74	4735	5	ehemotaxis	ehemotaxis	NNP
cord-015021-pol2qm74	4736	1	mad	mad	JJ
cord-015021-pol2qm74	4736	2	enzyme	enzyme	NN
cord-015021-pol2qm74	4736	3	-	-	HYPH
cord-015021-pol2qm74	4736	4	reieasing	reiease	VBG
cord-015021-pol2qm74	4737	1	~ssas	~ssas	NNP
cord-015021-pol2qm74	4737	2	's	be	VBZ
cord-015021-pol2qm74	4737	3	on	on	IN
cord-015021-pol2qm74	4737	4	msnocyte~	msnocyte~	NNP
cord-015021-pol2qm74	4737	5	and	and	CC
cord-015021-pol2qm74	4737	6	neatrophiis	neatrophiis	NNP
cord-015021-pol2qm74	4737	7	.	.	.
cord-015021-pol2qm74	4738	1	ELISA	ELISA	NNP
cord-015021-pol2qm74	4738	2	revealed	reveal	VBD
cord-015021-pol2qm74	4738	3	significenfly	significenfly	NNP
cord-015021-pol2qm74	4738	4	elevated	elevate	VBD
cord-015021-pol2qm74	4738	5	B	B	NNP
cord-015021-pol2qm74	4738	6	AL	AL	NNP
cord-015021-pol2qm74	4738	7	-	-	HYPH
cord-015021-pol2qm74	4738	8	eoneentrations	eoneentrations	NNP
cord-015021-pol2qm74	4738	9	o£MCP-	o£mcp-	NN
cord-015021-pol2qm74	4739	1	I	-PRON-	PRP
cord-015021-pol2qm74	4739	2	(	(	-LRB-
cord-015021-pol2qm74	4739	3	20.1	20.1	CD
cord-015021-pol2qm74	4739	4	ng]mg	ng]mg	NNP
cord-015021-pol2qm74	4739	5	aibumm	aibumm	NNP
cord-015021-pol2qm74	4739	6	)	)	-RRB-
cord-015021-pol2qm74	4739	7	in	in	IN
cord-015021-pol2qm74	4739	8	purisms	purism	NNS
cord-015021-pol2qm74	4739	9	with	with	IN
cord-015021-pol2qm74	4739	10	p	p	NN
cord-015021-pol2qm74	4739	11	~	~	CD
cord-015021-pol2qm74	4739	12	monary	monary	NNP
cord-015021-pol2qm74	4739	13	sarcoidodis	sarcoidodis	NNP
cord-015021-pol2qm74	4739	14	artd	artd	NNP
cord-015021-pol2qm74	4739	15	in	in	IN
cord-015021-pol2qm74	4739	16	IPF	IPF	NNP
cord-015021-pol2qm74	4739	17	(	(	-LRB-
cord-015021-pol2qm74	4739	18	41.8	41.8	CD
cord-015021-pol2qm74	4739	19	ng!mg	ng!mg	JJ
cord-015021-pol2qm74	4739	20	)	)	-RRB-
cord-015021-pol2qm74	4739	21	in	in	IN
cord-015021-pol2qm74	4739	22	comparises	comparise	NNS
cord-015021-pol2qm74	4739	23	to	to	IN
cord-015021-pol2qm74	4739	24	1.1	1.1	CD
cord-015021-pol2qm74	4739	25	normal	normal	JJ
cord-015021-pol2qm74	4739	26	individuals	individual	NNS
cord-015021-pol2qm74	4739	27	(	(	-LRB-
cord-015021-pol2qm74	4739	28	4.24	4.24	CD
cord-015021-pol2qm74	4739	29	ng	ng	NNP
cord-015021-pol2qm74	4739	30	/	/	SYM
cord-015021-pol2qm74	4739	31	mg	mg	NNP
cord-015021-pol2qm74	4739	32	)	)	-RRB-
cord-015021-pol2qm74	4739	33	and	and	CC
cord-015021-pol2qm74	4739	34	to	to	IN
cord-015021-pol2qm74	4739	35	15	15	CD
cord-015021-pol2qm74	4739	36	patients	patient	NNS
cord-015021-pol2qm74	4739	37	w	w	IN
cord-015021-pol2qm74	4739	38	~	~	CD
cord-015021-pol2qm74	4739	39	th	th	XX
cord-015021-pol2qm74	4739	40	obreic	obreic	JJ
cord-015021-pol2qm74	4739	41	broneNtis	broneNtis	NNP
cord-015021-pol2qm74	4739	42	(	(	-LRB-
cord-015021-pol2qm74	4739	43	CB	CB	NNP
cord-015021-pol2qm74	4739	44	)	)	-RRB-
cord-015021-pol2qm74	4739	45	(	(	-LRB-
cord-015021-pol2qm74	4739	46	~	~	NFP
cord-015021-pol2qm74	4739	47	,	,	,
cord-015021-pol2qm74	4739	48	16	16	CD
cord-015021-pol2qm74	4739	49	rig	rig	NN
cord-015021-pol2qm74	4739	50	/	/	SYM
cord-015021-pol2qm74	4739	51	rag	rag	NN
cord-015021-pol2qm74	4739	52	)	)	-RRB-
cord-015021-pol2qm74	4739	53	.	.	.
cord-015021-pol2qm74	4740	1	Similarly	similarly	RB
cord-015021-pol2qm74	4740	2	,	,	,
cord-015021-pol2qm74	4740	3	chemota*dc	chemota*dc	''
cord-015021-pol2qm74	4740	4	ac	ac	NN
cord-015021-pol2qm74	4740	5	~	~	NFP
cord-015021-pol2qm74	4740	6	A~	A~	NNPS
cord-015021-pol2qm74	4740	7	'	'	POS
cord-015021-pol2qm74	4740	8	for	for	IN
cord-015021-pol2qm74	4740	9	monocles	monocle	NNS
cord-015021-pol2qm74	4740	10	(	(	-LRB-
cord-015021-pol2qm74	4741	1	MCP-1	MCP-1	NNP
cord-015021-pol2qm74	4741	2	e.qu/va]ent	e.qu/va]ent	NNP
cord-015021-pol2qm74	4741	3	)	)	-RRB-
cord-015021-pol2qm74	4741	4	was	be	VBD
cord-015021-pol2qm74	4741	5	strongly	strongly	RB
cord-015021-pol2qm74	4741	6	increased	increase	VBN
cord-015021-pol2qm74	4741	7	in	in	IN
cord-015021-pol2qm74	4741	8	sareoidosis	sareoidosis	NNP
cord-015021-pol2qm74	4741	9	(	(	-LRB-
cord-015021-pol2qm74	4741	10	86.03	86.03	CD
cord-015021-pol2qm74	4741	11	ngJmg	ngJmg	NNP
cord-015021-pol2qm74	4741	12	)	)	-RRB-
cord-015021-pol2qm74	4741	13	as	as	RB
cord-015021-pol2qm74	4741	14	well	well	RB
cord-015021-pol2qm74	4741	15	as	as	IN
cord-015021-pol2qm74	4741	16	~n	~n	NNP
cord-015021-pol2qm74	4742	1	12F	12F	NNP
cord-015021-pol2qm74	4742	2	pag	pag	NNP
cord-015021-pol2qm74	4742	3	,	,	,
cord-015021-pol2qm74	4742	4	nts	nts	NNPS
cord-015021-pol2qm74	4742	5	(	(	-LRB-
cord-015021-pol2qm74	4742	6	54.47	54.47	CD
cord-015021-pol2qm74	4742	7	ng	ng	NNP
cord-015021-pol2qm74	4742	8	/	/	SYM
cord-015021-pol2qm74	4742	9	mg	mg	NNP
cord-015021-pol2qm74	4742	10	)	)	-RRB-
cord-015021-pol2qm74	4742	11	.	.	.
cord-015021-pol2qm74	4743	1	Norra.al	norra.al	CD
cord-015021-pol2qm74	4744	1	indlvidu	indlvidu	NNP
cord-015021-pol2qm74	4744	2	~	~	NNP
cord-015021-pol2qm74	4744	3	s	s	NNP
cord-015021-pol2qm74	4744	4	and	and	CC
cord-015021-pol2qm74	4744	5	CB	CB	NNP
cord-015021-pol2qm74	4744	6	patiants	patiants	NNP
cord-015021-pol2qm74	4744	7	hzd	hzd	NNP
cord-015021-pol2qm74	4744	8	a	a	DT
cord-015021-pol2qm74	4744	9	7	7	CD
cord-015021-pol2qm74	4744	10	.	.	.
cord-015021-pol2qm74	4745	1	Or	or	CC
cord-015021-pol2qm74	4745	2	3-fold	3-fold	CD
cord-015021-pol2qm74	4745	3	lower	low	JJR
cord-015021-pol2qm74	4746	1	~cn%i	~cn%i	NNP
cord-015021-pol2qm74	4746	2	~	~	NFP
cord-015021-pol2qm74	4746	3	y	y	NNP
cord-015021-pol2qm74	4746	4	,	,	,
cord-015021-pol2qm74	4746	5	re	re	NNP
cord-015021-pol2qm74	4746	6	~	~	NNP
cord-015021-pol2qm74	4746	7	peefively	peefively	NNP
cord-015021-pol2qm74	4746	8	.	.	.
cord-015021-pol2qm74	4747	1	Patients	patient	NNS
cord-015021-pol2qm74	4747	2	with	with	IN
cord-015021-pol2qm74	4747	3	IPF	IPF	NNP
cord-015021-pol2qm74	4747	4	and	and	CC
cord-015021-pol2qm74	4748	1	sarcoidosi~	sarcoidosi~	NNP
cord-015021-pol2qm74	4748	2	also	also	RB
cord-015021-pol2qm74	4748	3	h	h	NN
cord-015021-pol2qm74	4748	4	~	~	NFP
cord-015021-pol2qm74	4748	5	l	l	NNP
cord-015021-pol2qm74	4748	6	eIevated	eIevated	NNP
cord-015021-pol2qm74	4749	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	4749	2	IeveI~	IeveI~	NNP
cord-015021-pol2qm74	4749	3	(	(	-LRB-
cord-015021-pol2qm74	4749	4	15.5	15.5	CD
cord-015021-pol2qm74	4749	5	and	and	CC
cord-015021-pol2qm74	4749	6	26.0	26.0	CD
cord-015021-pol2qm74	4749	7	rig	rig	NN
cord-015021-pol2qm74	4749	8	/	/	SYM
cord-015021-pol2qm74	4749	9	rag	rag	NN
cord-015021-pol2qm74	4749	10	,	,	,
cord-015021-pol2qm74	4749	11	respe	respe	NNP
cord-015021-pol2qm74	4749	12	~	~	NFP
cord-015021-pol2qm74	4749	13	veIy	veiy	NN
cord-015021-pol2qm74	4749	14	;	;	:
cord-015021-pol2qm74	4749	15	nomzls	nomzls	NN
cord-015021-pol2qm74	4749	16	:	:	:
cord-015021-pol2qm74	4749	17	2.14	2.14	CD
cord-015021-pol2qm74	4749	18	rig	rig	NN
cord-015021-pol2qm74	4749	19	/	/	SYM
cord-015021-pol2qm74	4749	20	rag	rag	NN
cord-015021-pol2qm74	4749	21	;	;	:
cord-015021-pol2qm74	4749	22	CB	cb	NN
cord-015021-pol2qm74	4749	23	:	:	:
cord-015021-pol2qm74	4750	1	4.23	4.23	CD
cord-015021-pol2qm74	4750	2	ng	ng	NNP
cord-015021-pol2qm74	4750	3	/	/	SYM
cord-015021-pol2qm74	4750	4	mg	mg	NNP
cord-015021-pol2qm74	4750	5	)	)	-RRB-
cord-015021-pol2qm74	4750	6	mad	mad	JJ
cord-015021-pol2qm74	4750	7	nvatropMI	nvatropMI	NNP
cord-015021-pol2qm74	4750	8	ohemotax~	ohemotax~	JJ
cord-015021-pol2qm74	4750	9	(	(	-LRB-
cord-015021-pol2qm74	4750	10	60.25	60.25	CD
cord-015021-pol2qm74	4750	11	~'~d	~'~d	CD
cord-015021-pol2qm74	4750	12	49.68	49.68	CD
cord-015021-pol2qm74	4750	13	nNmg	nnmg	NN
cord-015021-pol2qm74	4750	14	,	,	,
cord-015021-pol2qm74	4750	15	res!z	res!z	NNP
cord-015021-pol2qm74	4750	16	~	~	NFP
cord-015021-pol2qm74	4750	17	ztiveiy	ztiveiy	NNP
cord-015021-pol2qm74	4750	18	;	;	:
cord-015021-pol2qm74	4750	19	aormals	aormal	NNS
cord-015021-pol2qm74	4750	20	:	:	:
cord-015021-pol2qm74	4750	21	0.25	0.25	CD
cord-015021-pol2qm74	4750	22	ng,'mg	ng,'mg	NNS
cord-015021-pol2qm74	4750	23	;	;	:
cord-015021-pol2qm74	4750	24	CB	CB	NNP
cord-015021-pol2qm74	4750	25	:	:	:
cord-015021-pol2qm74	4751	1	1L06	1l06	CD
cord-015021-pol2qm74	4751	2	ngmg	ngmg	NNP
cord-015021-pol2qm74	4751	3	)	)	-RRB-
cord-015021-pol2qm74	4751	4	.	.	.
cord-015021-pol2qm74	4752	1	These	these	DT
cord-015021-pol2qm74	4752	2	data	datum	NNS
cord-015021-pol2qm74	4752	3	suggest	suggest	VBP
cord-015021-pol2qm74	4752	4	that	that	IN
cord-015021-pol2qm74	4752	5	increased	increase	VBN
cord-015021-pol2qm74	4752	6	Ievels	Ievels	NNP
cord-015021-pol2qm74	4752	7	of	of	IN
cord-015021-pol2qm74	4752	8	borN	borN	NNP
cord-015021-pol2qm74	4752	9	MCP.1	MCP.1	NNP
cord-015021-pol2qm74	4753	1	~d	~d	NFP
cord-015021-pol2qm74	4753	2	IL-8	IL-8	NNP
cord-015021-pol2qm74	4753	3	may	may	MD
cord-015021-pol2qm74	4753	4	be	be	VB
cord-015021-pol2qm74	4753	5	oharacted	oharacte	VBN
cord-015021-pol2qm74	4753	6	~	~	NFP
cord-015021-pol2qm74	4753	7	tie	tie	NN
cord-015021-pol2qm74	4753	8	for	for	IN
cord-015021-pol2qm74	4753	9	~arcoidosis	~arcoidosis	CD
cord-015021-pol2qm74	4753	10	or	or	CC
cord-015021-pol2qm74	4753	11	IPF	IPF	NNP
cord-015021-pol2qm74	4754	1	_	_	NNP
cord-015021-pol2qm74	4755	1	It	-PRON-	PRP
cord-015021-pol2qm74	4755	2	appears	appear	VBZ
cord-015021-pol2qm74	4755	3	Iikely	iikely	RB
cord-015021-pol2qm74	4755	4	that	that	IN
cord-015021-pol2qm74	4755	5	both	both	DT
cord-015021-pol2qm74	4755	6	ehernoattraetants	ehernoattraetant	VBZ
cord-015021-pol2qm74	4755	7	~ontribute	~ontribute	NNP
cord-015021-pol2qm74	4755	8	to	to	IN
cord-015021-pol2qm74	4755	9	the	the	DT
cord-015021-pol2qm74	4755	10	influx	influx	JJ
cord-015021-pol2qm74	4755	11	ofmonocytes	ofmonocyte	NNS
cord-015021-pol2qm74	4755	12	and	and	CC
cord-015021-pol2qm74	4755	13	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4755	14	into	into	IN
cord-015021-pol2qm74	4755	15	the	the	DT
cord-015021-pol2qm74	4755	16	pulmonary	pulmonary	NN
cord-015021-pol2qm74	4755	17	alveoIus	alveoius	NN
cord-015021-pol2qm74	4756	1	and	and	CC
cord-015021-pol2qm74	4756	2	interStit	interStit	NNP
cord-015021-pol2qm74	4757	1	~um	~um	NNS
cord-015021-pol2qm74	4757	2	in	in	IN
cord-015021-pol2qm74	4757	3	these	these	DT
cord-015021-pol2qm74	4757	4	dlsea	dlsea	NN
cord-015021-pol2qm74	4757	5	~	~	.
cord-015021-pol2qm74	4757	6	es	es	XX
cord-015021-pol2qm74	4757	7	.	.	.
cord-015021-pol2qm74	4758	1	We	-PRON-	PRP
cord-015021-pol2qm74	4758	2	have	have	VBP
cord-015021-pol2qm74	4758	3	recently	recently	RB
cord-015021-pol2qm74	4758	4	shown	show	VBN
cord-015021-pol2qm74	4758	5	that	that	IN
cord-015021-pol2qm74	4758	6	the	the	DT
cord-015021-pol2qm74	4758	7	combined	combined	JJ
cord-015021-pol2qm74	4758	8	administration	administration	NN
cord-015021-pol2qm74	4758	9	of	of	IN
cord-015021-pol2qm74	4758	10	noninjurious	noninjurious	JJ
cord-015021-pol2qm74	4758	11	doses	dose	NNS
cord-015021-pol2qm74	4758	12	of	of	IN
cord-015021-pol2qm74	4758	13	LPS	LPS	NNP
cord-015021-pol2qm74	4758	14	and	and	CC
cord-015021-pol2qm74	4758	15	PAF	PAF	NNP
cord-015021-pol2qm74	4758	16	in	in	IN
cord-015021-pol2qm74	4758	17	the	the	DT
cord-015021-pol2qm74	4758	18	rat	rat	NN
cord-015021-pol2qm74	4758	19	produce	produce	VB
cord-015021-pol2qm74	4758	20	ARDS	ARDS	NNP
cord-015021-pol2qm74	4758	21	-	-	HYPH
cord-015021-pol2qm74	4758	22	like	like	JJ
cord-015021-pol2qm74	4758	23	lung	lung	NN
cord-015021-pol2qm74	4758	24	injury	injury	NN
cord-015021-pol2qm74	4758	25	characterized	characterize	VBN
cord-015021-pol2qm74	4758	26	by	by	IN
cord-015021-pol2qm74	4758	27	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4758	28	adhesion	adhesion	NN
cord-015021-pol2qm74	4758	29	to	to	IN
cord-015021-pol2qm74	4758	30	lung	lung	NN
cord-015021-pol2qm74	4758	31	capillary	capillary	NN
cord-015021-pol2qm74	4758	32	venules	venule	NNS
cord-015021-pol2qm74	4758	33	,	,	,
cord-015021-pol2qm74	4758	34	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4758	35	accumulation	accumulation	NN
cord-015021-pol2qm74	4758	36	in	in	IN
cord-015021-pol2qm74	4758	37	lung	lung	NN
cord-015021-pol2qm74	4758	38	parenchyma	parenchyma	NN
cord-015021-pol2qm74	4758	39	,	,	,
cord-015021-pol2qm74	4758	40	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4758	41	edema	edema	NN
cord-015021-pol2qm74	4758	42	,	,	,
cord-015021-pol2qm74	4758	43	and	and	CC
cord-015021-pol2qm74	4758	44	increased	increase	VBN
cord-015021-pol2qm74	4758	45	protein	protein	NN
cord-015021-pol2qm74	4758	46	and	and	CC
cord-015021-pol2qm74	4758	47	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4758	48	count	count	NN
cord-015021-pol2qm74	4758	49	in	in	IN
cord-015021-pol2qm74	4758	50	BAL	bal	NN
cord-015021-pol2qm74	4758	51	fluid	fluid	NN
cord-015021-pol2qm74	4758	52	.	.	.
cord-015021-pol2qm74	4759	1	This	this	DT
cord-015021-pol2qm74	4759	2	new	new	JJ
cord-015021-pol2qm74	4759	3	paradigm	paradigm	NN
cord-015021-pol2qm74	4759	4	of	of	IN
cord-015021-pol2qm74	4759	5	lung	lung	NN
cord-015021-pol2qm74	4759	6	injury	injury	NN
cord-015021-pol2qm74	4759	7	was	be	VBD
cord-015021-pol2qm74	4759	8	associated	associate	VBN
cord-015021-pol2qm74	4759	9	with	with	IN
cord-015021-pol2qm74	4759	10	elevated	elevated	JJ
cord-015021-pol2qm74	4759	11	serum	serum	NN
cord-015021-pol2qm74	4759	12	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	4759	13	and	and	CC
cord-015021-pol2qm74	4759	14	pretreatment	pretreatment	NN
cord-015021-pol2qm74	4759	15	with	with	IN
cord-015021-pol2qm74	4759	16	anti	anti	JJ
cord-015021-pol2qm74	4759	17	TNFa	TNFa	NNP
cord-015021-pol2qm74	4759	18	mAb	mAb	HYPH
cord-015021-pol2qm74	4759	19	dose	dose	NN
cord-015021-pol2qm74	4759	20	-	-	HYPH
cord-015021-pol2qm74	4759	21	dependently	dependently	RB
cord-015021-pol2qm74	4759	22	prevented	prevent	VBD
cord-015021-pol2qm74	4759	23	these	these	DT
cord-015021-pol2qm74	4759	24	responses	response	NNS
cord-015021-pol2qm74	4759	25	.	.	.
cord-015021-pol2qm74	4760	1	Also	also	RB
cord-015021-pol2qm74	4760	2	,	,	,
cord-015021-pol2qm74	4760	3	the	the	DT
cord-015021-pol2qm74	4760	4	combined	combined	JJ
cord-015021-pol2qm74	4760	5	administration	administration	NN
cord-015021-pol2qm74	4760	6	of	of	IN
cord-015021-pol2qm74	4760	7	LPS	LPS	NNP
cord-015021-pol2qm74	4760	8	and	and	CC
cord-015021-pol2qm74	4760	9	PAF	PAF	NNP
cord-015021-pol2qm74	4760	10	induced	induce	VBN
cord-015021-pol2qm74	4760	11	lung	lung	NN
cord-015021-pol2qm74	4760	12	mRNA	mrna	NN
cord-015021-pol2qm74	4760	13	levels	level	NNS
cord-015021-pol2qm74	4760	14	of	of	IN
cord-015021-pol2qm74	4760	15	TNFe~	TNFe~	NNS
cord-015021-pol2qm74	4760	16	(	(	-LRB-
cord-015021-pol2qm74	4760	17	5	5	CD
cord-015021-pol2qm74	4760	18	fold	fold	VB
cord-015021-pol2qm74	4760	19	vs.	vs.	FW
cord-015021-pol2qm74	4760	20	LPS	LPS	NNP
cord-015021-pol2qm74	4760	21	or	or	CC
cord-015021-pol2qm74	4760	22	PAF	PAF	NNP
cord-015021-pol2qm74	4760	23	alone	alone	RB
cord-015021-pol2qm74	4760	24	)	)	-RRB-
cord-015021-pol2qm74	4760	25	,	,	,
cord-015021-pol2qm74	4760	26	lL	lL	NNP
cord-015021-pol2qm74	4760	27	-	-	HYPH
cord-015021-pol2qm74	4760	28	lg	lg	NNP
cord-015021-pol2qm74	4760	29	(	(	-LRB-
cord-015021-pol2qm74	4760	30	80	80	CD
cord-015021-pol2qm74	4760	31	fold	fold	NN
cord-015021-pol2qm74	4760	32	)	)	-RRB-
cord-015021-pol2qm74	4760	33	,	,	,
cord-015021-pol2qm74	4760	34	KC	KC	NNP
cord-015021-pol2qm74	4760	35	(	(	-LRB-
cord-015021-pol2qm74	4760	36	60	60	CD
cord-015021-pol2qm74	4760	37	fold	fold	NN
cord-015021-pol2qm74	4760	38	)	)	-RRB-
cord-015021-pol2qm74	4760	39	and	and	CC
cord-015021-pol2qm74	4760	40	IL-6	IL-6	NNP
cord-015021-pol2qm74	4760	41	.	.	.
cord-015021-pol2qm74	4761	1	Taken	take	VBN
cord-015021-pol2qm74	4761	2	together	together	RB
cord-015021-pol2qm74	4761	3	,	,	,
cord-015021-pol2qm74	4761	4	these	these	DT
cord-015021-pol2qm74	4761	5	data	datum	NNS
cord-015021-pol2qm74	4761	6	suggest	suggest	VBP
cord-015021-pol2qm74	4761	7	that	that	IN
cord-015021-pol2qm74	4761	8	this	this	DT
cord-015021-pol2qm74	4761	9	new	new	JJ
cord-015021-pol2qm74	4761	10	paradigm	paradigm	NN
cord-015021-pol2qm74	4761	11	of	of	IN
cord-015021-pol2qm74	4761	12	lung	lung	NN
cord-015021-pol2qm74	4761	13	injury	injury	NN
cord-015021-pol2qm74	4761	14	is	be	VBZ
cord-015021-pol2qm74	4761	15	cytokinemediated	cytokinemediate	VBN
cord-015021-pol2qm74	4761	16	and	and	CC
cord-015021-pol2qm74	4761	17	that	that	IN
cord-015021-pol2qm74	4761	18	LPS	LPS	NNP
cord-015021-pol2qm74	4761	19	/	/	SYM
cord-015021-pol2qm74	4761	20	PAF	PAF	NNP
cord-015021-pol2qm74	4761	21	in	in	IN
cord-015021-pol2qm74	4761	22	vivo	vivo	NN
cord-015021-pol2qm74	4761	23	can	can	MD
cord-015021-pol2qm74	4761	24	functionally	functionally	RB
cord-015021-pol2qm74	4761	25	couple	couple	NN
cord-015021-pol2qm74	4761	26	to	to	IN
cord-015021-pol2qm74	4761	27	the	the	DT
cord-015021-pol2qm74	4761	28	activation	activation	NN
cord-015021-pol2qm74	4761	29	of	of	IN
cord-015021-pol2qm74	4761	30	gone	go	VBN
cord-015021-pol2qm74	4761	31	expression	expression	NN
cord-015021-pol2qm74	4761	32	of	of	IN
cord-015021-pol2qm74	4761	33	a	a	DT
cord-015021-pol2qm74	4761	34	multi	multi	JJ
cord-015021-pol2qm74	4761	35	-	-	JJ
cord-015021-pol2qm74	4761	36	cytokine	cytokine	JJ
cord-015021-pol2qm74	4761	37	network	network	NN
cord-015021-pol2qm74	4761	38	system	system	NN
cord-015021-pol2qm74	4761	39	,	,	,
cord-015021-pol2qm74	4761	40	all	all	DT
cord-015021-pol2qm74	4761	41	of	of	IN
cord-015021-pol2qm74	4761	42	which	which	WDT
cord-015021-pol2qm74	4761	43	may	may	MD
cord-015021-pol2qm74	4761	44	be	be	VB
cord-015021-pol2qm74	4761	45	involved	involve	VBN
cord-015021-pol2qm74	4761	46	in	in	IN
cord-015021-pol2qm74	4761	47	the	the	DT
cord-015021-pol2qm74	4761	48	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	4761	49	of	of	IN
cord-015021-pol2qm74	4761	50	ARDS	ARDS	NNP
cord-015021-pol2qm74	4761	51	.	.	.
cord-015021-pol2qm74	4762	1	Materials	material	NNS
cord-015021-pol2qm74	4762	2	and	and	CC
cord-015021-pol2qm74	4762	3	methods	method	NNS
cord-015021-pol2qm74	4762	4	.	.	.
cord-015021-pol2qm74	4763	1	The	the	DT
cord-015021-pol2qm74	4763	2	sheep	sheep	NN
cord-015021-pol2qm74	4763	3	model	model	NN
cord-015021-pol2qm74	4763	4	included	include	VBD
cord-015021-pol2qm74	4763	5	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	4763	6	shock	shock	NN
cord-015021-pol2qm74	4763	7	and	and	CC
cord-015021-pol2qm74	4763	8	closed	closed	JJ
cord-015021-pol2qm74	4763	9	femoral	femoral	JJ
cord-015021-pol2qm74	4763	10	nailing	nailing	NN
cord-015021-pol2qm74	4763	11	at	at	IN
cord-015021-pol2qm74	4763	12	day	day	NN
cord-015021-pol2qm74	4763	13	0	0	CD
cord-015021-pol2qm74	4763	14	,	,	,
cord-015021-pol2qm74	4763	15	12hourly	12hourly	JJ
cord-015021-pol2qm74	4763	16	injections	injection	NNS
cord-015021-pol2qm74	4763	17	of	of	IN
cord-015021-pol2qm74	4763	18	E.	E.	NNP
cord-015021-pol2qm74	4763	19	coli	coli	VBZ
cord-015021-pol2qm74	4763	20	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4763	21	and	and	CC
cord-015021-pol2qm74	4763	22	zymosan	zymosan	NNP
cord-015021-pol2qm74	4763	23	-	-	HYPH
cord-015021-pol2qm74	4763	24	activated	activate	VBN
cord-015021-pol2qm74	4763	25	autologous	autologous	JJ
cord-015021-pol2qm74	4763	26	plasma	plasma	NN
cord-015021-pol2qm74	4763	27	at	at	IN
cord-015021-pol2qm74	4763	28	clays	clay	NNS
cord-015021-pol2qm74	4763	29	1	1	CD
cord-015021-pol2qm74	4763	30	-	-	SYM
cord-015021-pol2qm74	4763	31	5	5	CD
cord-015021-pol2qm74	4763	32	and	and	CC
cord-015021-pol2qm74	4763	33	further	further	JJ
cord-015021-pol2qm74	4763	34	observation	observation	NN
cord-015021-pol2qm74	4763	35	and	and	CC
cord-015021-pol2qm74	4763	36	measurements	measurement	NNS
cord-015021-pol2qm74	4763	37	at	at	IN
cord-015021-pol2qm74	4763	38	days	day	NNS
cord-015021-pol2qm74	4763	39	6	6	CD
cord-015021-pol2qm74	4763	40	-	-	SYM
cord-015021-pol2qm74	4763	41	10	10	CD
cord-015021-pol2qm74	4763	42	.	.	.
cord-015021-pol2qm74	4764	1	From	from	IN
cord-015021-pol2qm74	4764	2	venous	venous	JJ
cord-015021-pol2qm74	4764	3	blood	blood	NN
cord-015021-pol2qm74	4764	4	and	and	CC
cord-015021-pol2qm74	4764	5	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	4764	6	lavage(BAL)fluid	lavage(BAL)fluid	NNP
cord-015021-pol2qm74	4764	7	of	of	IN
cord-015021-pol2qm74	4764	8	ten	ten	CD
cord-015021-pol2qm74	4764	9	merino	merino	NN
cord-015021-pol2qm74	4764	10	sheep	sheep	NNS
cord-015021-pol2qm74	4764	11	(	(	-LRB-
cord-015021-pol2qm74	4764	12	mean	mean	VB
cord-015021-pol2qm74	4764	13	weight	weight	NN
cord-015021-pol2qm74	4764	14	30	30	CD
cord-015021-pol2qm74	4764	15	kg	kg	NN
cord-015021-pol2qm74	4764	16	)	)	-RRB-
cord-015021-pol2qm74	4765	1	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4765	2	counts	count	NNS
cord-015021-pol2qm74	4765	3	(	(	-LRB-
cord-015021-pol2qm74	4765	4	10e6	10e6	CD
cord-015021-pol2qm74	4765	5	PMN	PMN	NNP
cord-015021-pol2qm74	4765	6	/	/	,
cord-015021-pol2qm74	4765	7	ml	ml	NN
cord-015021-pol2qm74	4765	8	blood	blood	NN
cord-015021-pol2qm74	4765	9	or	or	CC
cord-015021-pol2qm74	4765	10	epithelial	epithelial	JJ
cord-015021-pol2qm74	4765	11	lining	line	VBG
cord-015021-pol2qm74	4765	12	fluid	fluid	NN
cord-015021-pol2qm74	4765	13	-	-	HYPH
cord-015021-pol2qm74	4765	14	ELF-	elf-	NN
cord-015021-pol2qm74	4765	15	)	)	-RRB-
cord-015021-pol2qm74	4765	16	,	,	,
cord-015021-pol2qm74	4765	17	the	the	DT
cord-015021-pol2qm74	4765	18	ELF/	elf/	NN
cord-015021-pol2qm74	4765	19	plasma	plasma	NN
cord-015021-pol2qm74	4765	20	ratio	ratio	NN
cord-015021-pol2qm74	4765	21	of	of	IN
cord-015021-pol2qm74	4765	22	albumin	albumin	NN
cord-015021-pol2qm74	4765	23	(	(	-LRB-
cord-015021-pol2qm74	4765	24	R	r	NN
cord-015021-pol2qm74	4765	25	)	)	-RRB-
cord-015021-pol2qm74	4765	26	,	,	,
cord-015021-pol2qm74	4765	27	and	and	CC
cord-015021-pol2qm74	4765	28	the	the	DT
cord-015021-pol2qm74	4765	29	zymosan	zymosan	NNP
cord-015021-pol2qm74	4765	30	-	-	HYPH
cord-015021-pol2qm74	4765	31	induced	induce	VBN
cord-015021-pol2qm74	4765	32	(	(	-LRB-
cord-015021-pol2qm74	4765	33	stim	stim	NNP
cord-015021-pol2qm74	4765	34	)	)	-RRB-
cord-015021-pol2qm74	4765	35	and	and	CC
cord-015021-pol2qm74	4765	36	non	non	JJ
cord-015021-pol2qm74	4765	37	-	-	JJ
cord-015021-pol2qm74	4765	38	induced	induced	JJ
cord-015021-pol2qm74	4765	39	(	(	-LRB-
cord-015021-pol2qm74	4765	40	spont	spont	NN
cord-015021-pol2qm74	4765	41	)	)	-RRB-
cord-015021-pol2qm74	4766	1	chemiluminescence	chemiluminescence	NNP
cord-015021-pol2qm74	4766	2	response	response	NN
cord-015021-pol2qm74	4766	3	(	(	-LRB-
cord-015021-pol2qm74	4766	4	CL	CL	NNP
cord-015021-pol2qm74	4766	5	)	)	-RRB-
cord-015021-pol2qm74	4766	6	of	of	IN
cord-015021-pol2qm74	4766	7	blood	blood	NN
cord-015021-pol2qm74	4766	8	(	(	-LRB-
cord-015021-pol2qm74	4766	9	10e6	10e6	CD
cord-015021-pol2qm74	4766	10	cpm/250,000	cpm/250,000	:
cord-015021-pol2qm74	4766	11	PMN	PMN	NNP
cord-015021-pol2qm74	4766	12	)	)	-RRB-
cord-015021-pol2qm74	4766	13	,	,	,
cord-015021-pol2qm74	4766	14	and	and	CC
cord-015021-pol2qm74	4766	15	of	of	IN
cord-015021-pol2qm74	4766	16	blood	blood	NN
cord-015021-pol2qm74	4766	17	-	-	HYPH
cord-015021-pol2qm74	4766	18	and	and	CC
cord-015021-pol2qm74	4766	19	BAL	bal	NN
cord-015021-pol2qm74	4766	20	-	-	HYPH
cord-015021-pol2qm74	4766	21	isolated	isolate	VBN
cord-015021-pol2qm74	4766	22	PMN	PMN	NNP
cord-015021-pol2qm74	4766	23	(	(	-LRB-
cord-015021-pol2qm74	4766	24	10e6	10e6	CD
cord-015021-pol2qm74	4766	25	cpm/25,000	cpm/25,000	NNP
cord-015021-pol2qm74	4766	26	PMN	PMN	NNP
cord-015021-pol2qm74	4766	27	)	)	-RRB-
cord-015021-pol2qm74	4766	28	were	be	VBD
cord-015021-pol2qm74	4766	29	measured	measure	VBN
cord-015021-pol2qm74	4766	30	.	.	.
cord-015021-pol2qm74	4767	1	For	for	IN
cord-015021-pol2qm74	4767	2	statistical	statistical	JJ
cord-015021-pol2qm74	4767	3	calculations	calculation	NNS
cord-015021-pol2qm74	4767	4	the	the	DT
cord-015021-pol2qm74	4767	5	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	4767	6	test	test	NN
cord-015021-pol2qm74	4767	7	was	be	VBD
cord-015021-pol2qm74	4767	8	used	use	VBN
cord-015021-pol2qm74	4767	9	.	.	.
cord-015021-pol2qm74	4768	1	Data	datum	NNS
cord-015021-pol2qm74	4768	2	of	of	IN
cord-015021-pol2qm74	4768	3	the	the	DT
cord-015021-pol2qm74	4768	4	Changes	change	NNS
cord-015021-pol2qm74	4768	5	in	in	IN
cord-015021-pol2qm74	4768	6	polymorphonucleur	polymorphonucleur	NN
cord-015021-pol2qm74	4768	7	leukocyte	leukocyte	NN
cord-015021-pol2qm74	4768	8	(	(	-LRB-
cord-015021-pol2qm74	4768	9	PIVINL	PIVINL	NNP
cord-015021-pol2qm74	4768	10	)	)	-RRB-
cord-015021-pol2qm74	4768	11	metabolism	metabolism	NN
cord-015021-pol2qm74	4768	12	have	have	VBP
cord-015021-pol2qm74	4768	13	been	be	VBN
cord-015021-pol2qm74	4768	14	suggested	suggest	VBN
cord-015021-pol2qm74	4768	15	to	to	TO
cord-015021-pol2qm74	4768	16	play	play	VB
cord-015021-pol2qm74	4768	17	a	a	DT
cord-015021-pol2qm74	4768	18	pivotal	pivotal	JJ
cord-015021-pol2qm74	4768	19	part	part	NN
cord-015021-pol2qm74	4768	20	in	in	IN
cord-015021-pol2qm74	4768	21	the	the	DT
cord-015021-pol2qm74	4768	22	post	post	JJ
cord-015021-pol2qm74	4768	23	-	-	JJ
cord-015021-pol2qm74	4768	24	traumatic	traumatic	JJ
cord-015021-pol2qm74	4768	25	systemic	systemic	JJ
cord-015021-pol2qm74	4768	26	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4768	27	response	response	NN
cord-015021-pol2qm74	4768	28	syndrome	syndrome	NN
cord-015021-pol2qm74	4768	29	.	.	.
cord-015021-pol2qm74	4769	1	The	the	DT
cord-015021-pol2qm74	4769	2	underlying	underlying	JJ
cord-015021-pol2qm74	4769	3	cellular	cellular	JJ
cord-015021-pol2qm74	4769	4	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4769	5	which	which	WDT
cord-015021-pol2qm74	4769	6	control	control	VBP
cord-015021-pol2qm74	4769	7	this	this	DT
cord-015021-pol2qm74	4769	8	response	response	NN
cord-015021-pol2qm74	4769	9	are	be	VBP
cord-015021-pol2qm74	4769	10	not	not	RB
cord-015021-pol2qm74	4769	11	yet	yet	RB
cord-015021-pol2qm74	4769	12	completely	completely	RB
cord-015021-pol2qm74	4769	13	understood	understand	VBN
cord-015021-pol2qm74	4769	14	.	.	.
cord-015021-pol2qm74	4770	1	Since	since	IN
cord-015021-pol2qm74	4770	2	the	the	DT
cord-015021-pol2qm74	4770	3	'	'	``
cord-015021-pol2qm74	4770	4	Ca	Ca	NNP
cord-015021-pol2qm74	4770	5	2	2	CD
cord-015021-pol2qm74	4770	6	+	+	SYM
cord-015021-pol2qm74	4770	7	second	second	JJ
cord-015021-pol2qm74	4770	8	messenger'-system	messenger'-system	NNP
cord-015021-pol2qm74	4770	9	has	have	VBZ
cord-015021-pol2qm74	4770	10	been	be	VBN
cord-015021-pol2qm74	4770	11	shown	show	VBN
cord-015021-pol2qm74	4770	12	to	to	TO
cord-015021-pol2qm74	4770	13	be	be	VB
cord-015021-pol2qm74	4770	14	involved	involve	VBN
cord-015021-pol2qm74	4770	15	in	in	IN
cord-015021-pol2qm74	4770	16	regulation	regulation	NN
cord-015021-pol2qm74	4770	17	of	of	IN
cord-015021-pol2qm74	4770	18	PMNL-'respiratory	pmnl-'respiratory	CD
cord-015021-pol2qm74	4770	19	burst	burst	NN
cord-015021-pol2qm74	4770	20	'	'	''
cord-015021-pol2qm74	4770	21	,	,	,
cord-015021-pol2qm74	4770	22	we	-PRON-	PRP
cord-015021-pol2qm74	4770	23	investigated	investigate	VBD
cord-015021-pol2qm74	4770	24	changes	change	NNS
cord-015021-pol2qm74	4770	25	in	in	IN
cord-015021-pol2qm74	4770	26	PMNL	PMNL	NNP
cord-015021-pol2qm74	4770	27	-	-	HYPH
cord-015021-pol2qm74	4770	28	Ca	Ca	NNP
cord-015021-pol2qm74	4770	29	z÷	z÷	NN
cord-015021-pol2qm74	4770	30	regulation	regulation	NN
cord-015021-pol2qm74	4770	31	in	in	IN
cord-015021-pol2qm74	4770	32	relation	relation	NN
cord-015021-pol2qm74	4770	33	to	to	IN
cord-015021-pol2qm74	4770	34	oxygen	oxygen	NN
cord-015021-pol2qm74	4770	35	free	free	JJ
cord-015021-pol2qm74	4770	36	radical	radical	JJ
cord-015021-pol2qm74	4770	37	mediated	mediate	VBN
cord-015021-pol2qm74	4770	38	injury	injury	NN
cord-015021-pol2qm74	4770	39	.	.	.
cord-015021-pol2qm74	4771	1	Methods	method	NNS
cord-015021-pol2qm74	4771	2	.	.	.
cord-015021-pol2qm74	4772	1	In	in	IN
cord-015021-pol2qm74	4772	2	12	12	CD
cord-015021-pol2qm74	4772	3	polytranmatized	polytranmatize	VBN
cord-015021-pol2qm74	4772	4	patients	patient	NNS
cord-015021-pol2qm74	4772	5	(	(	-LRB-
cord-015021-pol2qm74	4772	6	mean	mean	VB
cord-015021-pol2qm74	4772	7	injury	injury	NN
cord-015021-pol2qm74	4772	8	severity	severity	NN
cord-015021-pol2qm74	4772	9	score	score	NN
cord-015021-pol2qm74	4772	10	=	=	SYM
cord-015021-pol2qm74	4772	11	32	32	CD
cord-015021-pol2qm74	4772	12	)	)	-RRB-
cord-015021-pol2qm74	4772	13	arterial	arterial	JJ
cord-015021-pol2qm74	4772	14	and	and	CC
cord-015021-pol2qm74	4772	15	venous	venous	JJ
cord-015021-pol2qm74	4772	16	blood	blood	NN
cord-015021-pol2qm74	4772	17	samples	sample	NNS
cord-015021-pol2qm74	4772	18	during	during	IN
cord-015021-pol2qm74	4772	19	15	15	CD
cord-015021-pol2qm74	4772	20	days	day	NNS
cord-015021-pol2qm74	4772	21	.	.	.
cord-015021-pol2qm74	4773	1	Daily	daily	JJ
cord-015021-pol2qm74	4773	2	evaluation	evaluation	NN
cord-015021-pol2qm74	4773	3	of	of	IN
cord-015021-pol2qm74	4773	4	Horowitz	Horowitz	NNP
cord-015021-pol2qm74	4773	5	-	-	HYPH
cord-015021-pol2qm74	4773	6	quotiant	quotiant	NNP
cord-015021-pol2qm74	4773	7	(	(	-LRB-
cord-015021-pol2qm74	4773	8	PO2	PO2	NNP
cord-015021-pol2qm74	4773	9	/	/	SYM
cord-015021-pol2qm74	4773	10	FiO2	FiO2	NNP
cord-015021-pol2qm74	4773	11	)	)	-RRB-
cord-015021-pol2qm74	4773	12	,	,	,
cord-015021-pol2qm74	4773	13	plasma	plasma	NN
cord-015021-pol2qm74	4773	14	lactate	lactate	NN
cord-015021-pol2qm74	4773	15	(	(	-LRB-
cord-015021-pol2qm74	4773	16	mg	mg	NNP
cord-015021-pol2qm74	4773	17	/	/	SYM
cord-015021-pol2qm74	4773	18	dl	dl	NNP
cord-015021-pol2qm74	4773	19	)	)	-RRB-
cord-015021-pol2qm74	4773	20	and	and	CC
cord-015021-pol2qm74	4773	21	body	body	NN
cord-015021-pol2qm74	4773	22	temperature	temperature	NN
cord-015021-pol2qm74	4773	23	(	(	-LRB-
cord-015021-pol2qm74	4773	24	Results	result	NNS
cord-015021-pol2qm74	4773	25	.	.	.
cord-015021-pol2qm74	4774	1	Body	body	NN
cord-015021-pol2qm74	4774	2	temperature	temperature	NN
cord-015021-pol2qm74	4774	3	peaked	peak	VBD
cord-015021-pol2qm74	4774	4	at	at	IN
cord-015021-pol2qm74	4774	5	day	day	NN
cord-015021-pol2qm74	4774	6	6	6	CD
cord-015021-pol2qm74	4774	7	and	and	CC
cord-015021-pol2qm74	4774	8	7	7	CD
cord-015021-pol2qm74	4774	9	(	(	-LRB-
cord-015021-pol2qm74	4774	10	day	day	NN
cord-015021-pol2qm74	4774	11	0	0	CD
cord-015021-pol2qm74	4774	12	:	:	:
cord-015021-pol2qm74	4774	13	36+.4	36+.4	CD
cord-015021-pol2qm74	4774	14	;	;	:
cord-015021-pol2qm74	4774	15	day	day	NN
cord-015021-pol2qm74	4774	16	7	7	CD
cord-015021-pol2qm74	4774	17	:	:	SYM
cord-015021-pol2qm74	4774	18	39.8+.4	39.8+.4	CD
cord-015021-pol2qm74	4774	19	)	)	-RRB-
cord-015021-pol2qm74	4774	20	.	.	.
cord-015021-pol2qm74	4775	1	Plasma	plasma	NN
cord-015021-pol2qm74	4775	2	lactate	lactate	NN
cord-015021-pol2qm74	4775	3	was	be	VBD
cord-015021-pol2qm74	4775	4	significantly	significantly	RB
cord-015021-pol2qm74	4775	5	increased	increase	VBN
cord-015021-pol2qm74	4775	6	at	at	IN
cord-015021-pol2qm74	4775	7	day	day	NN
cord-015021-pol2qm74	4775	8	l	l	NNP
cord-015021-pol2qm74	4775	9	(	(	-LRB-
cord-015021-pol2qm74	4775	10	36	36	CD
cord-015021-pol2qm74	4775	11	+	+	SYM
cord-015021-pol2qm74	4775	12	2	2	CD
cord-015021-pol2qm74	4775	13	)	)	-RRB-
cord-015021-pol2qm74	4775	14	and	and	CC
cord-015021-pol2qm74	4775	15	day	day	NN
cord-015021-pol2qm74	4775	16	7	7	CD
cord-015021-pol2qm74	4775	17	(	(	-LRB-
cord-015021-pol2qm74	4775	18	16.2	16.2	CD
cord-015021-pol2qm74	4775	19	+	+	SYM
cord-015021-pol2qm74	4775	20	2	2	CD
cord-015021-pol2qm74	4775	21	)	)	-RRB-
cord-015021-pol2qm74	4775	22	.	.	.
cord-015021-pol2qm74	4776	1	Hurowitz	Hurowitz	NNP
cord-015021-pol2qm74	4776	2	-	-	HYPH
cord-015021-pol2qm74	4776	3	quotient	quotient	NN
cord-015021-pol2qm74	4776	4	(	(	-LRB-
cord-015021-pol2qm74	4776	5	day	day	NN
cord-015021-pol2qm74	4776	6	0	0	CD
cord-015021-pol2qm74	4776	7	:	:	:
cord-015021-pol2qm74	4776	8	344	344	CD
cord-015021-pol2qm74	4776	9	+	+	SYM
cord-015021-pol2qm74	4776	10	43	43	CD
cord-015021-pol2qm74	4776	11	)	)	-RRB-
cord-015021-pol2qm74	4776	12	was	be	VBD
cord-015021-pol2qm74	4776	13	low	low	JJ
cord-015021-pol2qm74	4776	14	at	at	IN
cord-015021-pol2qm74	4776	15	day	day	NN
cord-015021-pol2qm74	4776	16	4	4	CD
cord-015021-pol2qm74	4776	17	(	(	-LRB-
cord-015021-pol2qm74	4776	18	199	199	CD
cord-015021-pol2qm74	4776	19	+	+	SYM
cord-015021-pol2qm74	4776	20	19	19	CD
cord-015021-pol2qm74	4776	21	)	)	-RRB-
cord-015021-pol2qm74	4776	22	and	and	CC
cord-015021-pol2qm74	4776	23	day	day	NN
cord-015021-pol2qm74	4776	24	7	7	CD
cord-015021-pol2qm74	4776	25	to	to	IN
cord-015021-pol2qm74	4776	26	10	10	CD
cord-015021-pol2qm74	4776	27	(	(	-LRB-
cord-015021-pol2qm74	4776	28	178	178	CD
cord-015021-pol2qm74	4776	29	+	+	SYM
cord-015021-pol2qm74	4776	30	25)(p<.05	25)(p<.05	CD
cord-015021-pol2qm74	4776	31	)	)	-RRB-
cord-015021-pol2qm74	4776	32	.	.	.
cord-015021-pol2qm74	4777	1	At	at	IN
cord-015021-pol2qm74	4777	2	day	day	NN
cord-015021-pol2qm74	4777	3	7	7	CD
cord-015021-pol2qm74	4777	4	a	a	DT
cord-015021-pol2qm74	4777	5	substantial	substantial	JJ
cord-015021-pol2qm74	4777	6	rise	rise	NN
cord-015021-pol2qm74	4777	7	in	in	IN
cord-015021-pol2qm74	4777	8	venous	venous	JJ
cord-015021-pol2qm74	4777	9	PMNL	pmnl	NN
cord-015021-pol2qm74	4777	10	-	-	HYPH
cord-015021-pol2qm74	4777	11	superoxide	superoxide	NN
cord-015021-pol2qm74	4777	12	production	production	NN
cord-015021-pol2qm74	4777	13	(	(	-LRB-
cord-015021-pol2qm74	4777	14	day	day	NN
cord-015021-pol2qm74	4777	15	5	5	CD
cord-015021-pol2qm74	4777	16	:	:	:
cord-015021-pol2qm74	4778	1	1.9+_.45	1.9+_.45	CD
cord-015021-pol2qm74	4778	2	,	,	,
cord-015021-pol2qm74	4778	3	day	day	NN
cord-015021-pol2qm74	4778	4	7	7	CD
cord-015021-pol2qm74	4778	5	:	:	SYM
cord-015021-pol2qm74	4778	6	3.3+.7	3.3+.7	CD
cord-015021-pol2qm74	4778	7	,	,	,
cord-015021-pol2qm74	4778	8	day	day	NN
cord-015021-pol2qm74	4778	9	9	9	CD
cord-015021-pol2qm74	4778	10	:	:	:
cord-015021-pol2qm74	4779	1	1.72+_.8	1.72+_.8	LS
cord-015021-pol2qm74	4779	2	)	)	-RRB-
cord-015021-pol2qm74	4779	3	,	,	,
cord-015021-pol2qm74	4779	4	oecured	oecure	VBN
cord-015021-pol2qm74	4779	5	with	with	IN
cord-015021-pol2qm74	4779	6	significant	significant	JJ
cord-015021-pol2qm74	4779	7	increase	increase	NN
cord-015021-pol2qm74	4779	8	in	in	IN
cord-015021-pol2qm74	4779	9	plasma	plasma	NN
cord-015021-pol2qm74	4779	10	lipid	lipid	NN
cord-015021-pol2qm74	4779	11	peroxidation	peroxidation	NN
cord-015021-pol2qm74	4779	12	(	(	-LRB-
cord-015021-pol2qm74	4779	13	day	day	NN
cord-015021-pol2qm74	4779	14	1:0.6	1:0.6	CD
cord-015021-pol2qm74	4779	15	+	+	SYM
cord-015021-pol2qm74	4779	16	0.2	0.2	CD
cord-015021-pol2qm74	4779	17	;	;	:
cord-015021-pol2qm74	4779	18	day	day	NN
cord-015021-pol2qm74	4779	19	7	7	CD
cord-015021-pol2qm74	4779	20	:	:	SYM
cord-015021-pol2qm74	4779	21	1.3	1.3	CD
cord-015021-pol2qm74	4779	22	+	+	SYM
cord-015021-pol2qm74	4779	23	0.2	0.2	CD
cord-015021-pol2qm74	4779	24	)	)	-RRB-
cord-015021-pol2qm74	4779	25	.	.	.
cord-015021-pol2qm74	4780	1	PIVIN~-myeloperoxidase	pivin~-myeloperoxidase	DT
cord-015021-pol2qm74	4780	2	activity	activity	NN
cord-015021-pol2qm74	4780	3	was	be	VBD
cord-015021-pol2qm74	4780	4	high	high	JJ
cord-015021-pol2qm74	4780	5	at	at	IN
cord-015021-pol2qm74	4780	6	day	day	NN
cord-015021-pol2qm74	4780	7	2	2	CD
cord-015021-pol2qm74	4780	8	(	(	-LRB-
cord-015021-pol2qm74	4780	9	2.3	2.3	CD
cord-015021-pol2qm74	4780	10	+	+	SYM
cord-015021-pol2qm74	4780	11	--.5	--.5	NN
cord-015021-pol2qm74	4780	12	)	)	-RRB-
cord-015021-pol2qm74	4780	13	and	and	CC
cord-015021-pol2qm74	4780	14	then	then	RB
cord-015021-pol2qm74	4780	15	continuously	continuously	RB
cord-015021-pol2qm74	4780	16	declined	decline	VBD
cord-015021-pol2qm74	4780	17	(	(	-LRB-
cord-015021-pol2qm74	4780	18	day	day	NN
cord-015021-pol2qm74	4780	19	7	7	CD
cord-015021-pol2qm74	4780	20	:	:	SYM
cord-015021-pol2qm74	4780	21	1.3+.3	1.3+.3	CD
cord-015021-pol2qm74	4780	22	)	)	-RRB-
cord-015021-pol2qm74	4780	23	.	.	.
cord-015021-pol2qm74	4781	1	Plasma	plasma	NN
cord-015021-pol2qm74	4781	2	antiexidant	antiexidant	JJ
cord-015021-pol2qm74	4781	3	activity	activity	NN
cord-015021-pol2qm74	4781	4	(	(	-LRB-
cord-015021-pol2qm74	4781	5	glutathione	glutathione	NN
cord-015021-pol2qm74	4781	6	pemxidase	pemxidase	NN
cord-015021-pol2qm74	4781	7	)	)	-RRB-
cord-015021-pol2qm74	4781	8	was	be	VBD
cord-015021-pol2qm74	4781	9	reduced	reduce	VBN
cord-015021-pol2qm74	4781	10	by	by	IN
cord-015021-pol2qm74	4781	11	34	34	CD
cord-015021-pol2qm74	4781	12	%	%	NN
cord-015021-pol2qm74	4781	13	at	at	IN
cord-015021-pol2qm74	4781	14	day	day	NN
cord-015021-pol2qm74	4781	15	7	7	CD
cord-015021-pol2qm74	4781	16	(	(	-LRB-
cord-015021-pol2qm74	4781	17	day	day	NN
cord-015021-pol2qm74	4781	18	1	1	CD
cord-015021-pol2qm74	4781	19	:	:	:
cord-015021-pol2qm74	4781	20	5.3+.3	5.3+.3	CD
cord-015021-pol2qm74	4781	21	;	;	:
cord-015021-pol2qm74	4781	22	day	day	NN
cord-015021-pol2qm74	4781	23	4	4	CD
cord-015021-pol2qm74	4781	24	:	:	:
cord-015021-pol2qm74	4781	25	4.4+_.2	4.4+_.2	CD
cord-015021-pol2qm74	4781	26	;	;	:
cord-015021-pol2qm74	4781	27	day	day	NN
cord-015021-pol2qm74	4781	28	7	7	CD
cord-015021-pol2qm74	4781	29	:	:	:
cord-015021-pol2qm74	4781	30	3.5+.2	3.5+.2	CD
cord-015021-pol2qm74	4781	31	)	)	-RRB-
cord-015021-pol2qm74	4781	32	.	.	.
cord-015021-pol2qm74	4782	1	Whereas	whereas	IN
cord-015021-pol2qm74	4782	2	basal	basal	NN
cord-015021-pol2qm74	4783	1	Ca	ca	NN
cord-015021-pol2qm74	4783	2	2	2	CD
cord-015021-pol2qm74	4783	3	+	+	CC
cord-015021-pol2qm74	4783	4	concentration	concentration	NN
cord-015021-pol2qm74	4783	5	remained	remain	VBD
cord-015021-pol2qm74	4783	6	unchanged	unchanged	JJ
cord-015021-pol2qm74	4783	7	(	(	-LRB-
cord-015021-pol2qm74	4783	8	day	day	NN
cord-015021-pol2qm74	4783	9	4	4	CD
cord-015021-pol2qm74	4783	10	:	:	:
cord-015021-pol2qm74	4783	11	68+_17	68+_17	CD
cord-015021-pol2qm74	4783	12	,	,	,
cord-015021-pol2qm74	4783	13	day	day	NN
cord-015021-pol2qm74	4783	14	7	7	CD
cord-015021-pol2qm74	4783	15	:	:	:
cord-015021-pol2qm74	4783	16	68+_15	68+_15	CD
cord-015021-pol2qm74	4783	17	)	)	-RRB-
cord-015021-pol2qm74	4783	18	,	,	,
cord-015021-pol2qm74	4783	19	FMLP	FMLP	NNP
cord-015021-pol2qm74	4783	20	-	-	HYPH
cord-015021-pol2qm74	4783	21	stimulated	stimulate	VBN
cord-015021-pol2qm74	4783	22	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	4784	1	Ca	ca	NN
cord-015021-pol2qm74	4784	2	2	2	CD
cord-015021-pol2qm74	4784	3	+	+	CD
cord-015021-pol2qm74	4785	1	mobilization	mobilization	NN
cord-015021-pol2qm74	4785	2	increased	increase	VBD
cord-015021-pol2qm74	4785	3	at	at	IN
cord-015021-pol2qm74	4785	4	day	day	NN
cord-015021-pol2qm74	4785	5	7	7	CD
cord-015021-pol2qm74	4785	6	(	(	-LRB-
cord-015021-pol2qm74	4785	7	day	day	NN
cord-015021-pol2qm74	4785	8	4	4	CD
cord-015021-pol2qm74	4785	9	:	:	:
cord-015021-pol2qm74	4785	10	457	457	CD
cord-015021-pol2qm74	4785	11	+	+	SYM
cord-015021-pol2qm74	4785	12	89	89	CD
cord-015021-pol2qm74	4785	13	,	,	,
cord-015021-pol2qm74	4785	14	day	day	NN
cord-015021-pol2qm74	4785	15	7	7	CD
cord-015021-pol2qm74	4785	16	:	:	SYM
cord-015021-pol2qm74	4785	17	11084410	11084410	CD
cord-015021-pol2qm74	4785	18	,	,	,
cord-015021-pol2qm74	4785	19	day	day	NN
cord-015021-pol2qm74	4785	20	9	9	CD
cord-015021-pol2qm74	4785	21	:	:	:
cord-015021-pol2qm74	4785	22	670	670	CD
cord-015021-pol2qm74	4785	23	+	+	SYM
cord-015021-pol2qm74	4785	24	262	262	CD
cord-015021-pol2qm74	4785	25	)	)	-RRB-
cord-015021-pol2qm74	4785	26	.	.	.
cord-015021-pol2qm74	4786	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	4786	2	.	.	.
cord-015021-pol2qm74	4787	1	The	the	DT
cord-015021-pol2qm74	4787	2	present	present	JJ
cord-015021-pol2qm74	4787	3	study	study	NN
cord-015021-pol2qm74	4787	4	in	in	IN
cord-015021-pol2qm74	4787	5	polytraumatized	polytraumatize	VBN
cord-015021-pol2qm74	4787	6	patients	patient	NNS
cord-015021-pol2qm74	4787	7	shows	show	VBZ
cord-015021-pol2qm74	4787	8	,	,	,
cord-015021-pol2qm74	4787	9	that	that	IN
cord-015021-pol2qm74	4787	10	seven	seven	CD
cord-015021-pol2qm74	4787	11	days	day	NNS
cord-015021-pol2qm74	4787	12	after	after	IN
cord-015021-pol2qm74	4787	13	injury	injury	NN
cord-015021-pol2qm74	4787	14	the	the	DT
cord-015021-pol2qm74	4787	15	agonist	agonist	NN
cord-015021-pol2qm74	4787	16	-	-	HYPH
cord-015021-pol2qm74	4787	17	induced	induce	VBN
cord-015021-pol2qm74	4787	18	PMNL	PMNL	NNP
cord-015021-pol2qm74	4788	1	Ca	ca	NN
cord-015021-pol2qm74	4788	2	2	2	CD
cord-015021-pol2qm74	4788	3	+	+	CC
cord-015021-pol2qm74	4788	4	mobilization	mobilization	NN
cord-015021-pol2qm74	4788	5	is	be	VBZ
cord-015021-pol2qm74	4788	6	significantly	significantly	RB
cord-015021-pol2qm74	4788	7	enhanced	enhance	VBN
cord-015021-pol2qm74	4788	8	.	.	.
cord-015021-pol2qm74	4789	1	At	at	IN
cord-015021-pol2qm74	4789	2	the	the	DT
cord-015021-pol2qm74	4789	3	same	same	JJ
cord-015021-pol2qm74	4789	4	time	time	NN
cord-015021-pol2qm74	4789	5	,	,	,
cord-015021-pol2qm74	4789	6	PMNL	PMNL	NNP
cord-015021-pol2qm74	4789	7	-	-	HYPH
cord-015021-pol2qm74	4789	8	oxygen	oxygen	NN
cord-015021-pol2qm74	4789	9	free	free	JJ
cord-015021-pol2qm74	4789	10	radical	radical	JJ
cord-015021-pol2qm74	4789	11	release	release	NN
cord-015021-pol2qm74	4789	12	and	and	CC
cord-015021-pol2qm74	4789	13	phagocytotic	phagocytotic	JJ
cord-015021-pol2qm74	4789	14	activity	activity	NN
cord-015021-pol2qm74	4789	15	,	,	,
cord-015021-pol2qm74	4789	16	systemic	systemic	JJ
cord-015021-pol2qm74	4789	17	fever	fever	NN
cord-015021-pol2qm74	4789	18	response	response	NN
cord-015021-pol2qm74	4789	19	and	and	CC
cord-015021-pol2qm74	4789	20	lactate	lactate	NN
cord-015021-pol2qm74	4789	21	concentrations	concentration	NNS
cord-015021-pol2qm74	4789	22	were	be	VBD
cord-015021-pol2qm74	4789	23	maximal	maximal	JJ
cord-015021-pol2qm74	4789	24	.	.	.
cord-015021-pol2qm74	4790	1	These	these	DT
cord-015021-pol2qm74	4790	2	observations	observation	NNS
cord-015021-pol2qm74	4790	3	were	be	VBD
cord-015021-pol2qm74	4790	4	accompanied	accompany	VBN
cord-015021-pol2qm74	4790	5	by	by	IN
cord-015021-pol2qm74	4790	6	post	post	JJ
cord-015021-pol2qm74	4790	7	-	-	JJ
cord-015021-pol2qm74	4790	8	tranmatic	tranmatic	JJ
cord-015021-pol2qm74	4790	9	respiratory	respiratory	JJ
cord-015021-pol2qm74	4790	10	failure	failure	NN
cord-015021-pol2qm74	4790	11	and	and	CC
cord-015021-pol2qm74	4790	12	in	in	IN
cord-015021-pol2qm74	4790	13	some	some	DT
cord-015021-pol2qm74	4790	14	patients	patient	NNS
cord-015021-pol2qm74	4790	15	by	by	IN
cord-015021-pol2qm74	4790	16	clinical	clinical	JJ
cord-015021-pol2qm74	4790	17	signs	sign	NNS
cord-015021-pol2qm74	4790	18	of	of	IN
cord-015021-pol2qm74	4790	19	multiple	multiple	JJ
cord-015021-pol2qm74	4790	20	organ	organ	NN
cord-015021-pol2qm74	4790	21	failure	failure	NN
cord-015021-pol2qm74	4790	22	.	.	.
cord-015021-pol2qm74	4791	1	Preliminary	preliminary	JJ
cord-015021-pol2qm74	4791	2	data	datum	NNS
cord-015021-pol2qm74	4791	3	from	from	IN
cord-015021-pol2qm74	4791	4	an	an	DT
cord-015021-pol2qm74	4791	5	ongoing	ongoing	JJ
cord-015021-pol2qm74	4791	6	study	study	NN
cord-015021-pol2qm74	4791	7	using	use	VBG
cord-015021-pol2qm74	4791	8	HES	HES	NNP
cord-015021-pol2qm74	4791	9	-	-	HYPH
cord-015021-pol2qm74	4791	10	and	and	CC
cord-015021-pol2qm74	4791	11	dextran	dextran	NN
cord-015021-pol2qm74	4791	12	-	-	HYPH
cord-015021-pol2qm74	4791	13	infusions	infusion	NNS
cord-015021-pol2qm74	4791	14	in	in	IN
cord-015021-pol2qm74	4791	15	these	these	DT
cord-015021-pol2qm74	4791	16	patients	patient	NNS
cord-015021-pol2qm74	4791	17	show	show	VBP
cord-015021-pol2qm74	4791	18	attenuation	attenuation	NN
cord-015021-pol2qm74	4791	19	of	of	IN
cord-015021-pol2qm74	4791	20	this	this	DT
cord-015021-pol2qm74	4791	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4791	22	response	response	NN
cord-015021-pol2qm74	4791	23	.	.	.
cord-015021-pol2qm74	4792	1	Stefan	Stefan	NNP
cord-015021-pol2qm74	4792	2	Rose	Rose	NNP
cord-015021-pol2qm74	4792	3	,	,	,
cord-015021-pol2qm74	4792	4	M.D.	M.D.	NNP
cord-015021-pol2qm74	4792	5	,	,	,
cord-015021-pol2qm74	4792	6	Trauma	Trauma	NNP
cord-015021-pol2qm74	4792	7	Surgery	Surgery	NNP
cord-015021-pol2qm74	4792	8	,	,	,
cord-015021-pol2qm74	4792	9	Univ	Univ	NNP
cord-015021-pol2qm74	4792	10	.	.	NNP
cord-015021-pol2qm74	4792	11	of	of	IN
cord-015021-pol2qm74	4792	12	Saarland	Saarland	NNP
cord-015021-pol2qm74	4792	13	,	,	,
cord-015021-pol2qm74	4792	14	66421	66421	CD
cord-015021-pol2qm74	4793	1	Homburg	Homburg	NNP
cord-015021-pol2qm74	4793	2	/	/	SYM
cord-015021-pol2qm74	4793	3	Saar	Saar	NNP
cord-015021-pol2qm74	4793	4	1Donnelly	1Donnelly	NNP
cord-015021-pol2qm74	4793	5	SC	SC	NNP
cord-015021-pol2qm74	4793	6	,	,	,
cord-015021-pol2qm74	4793	7	1Haslett	1Haslett	NNP
cord-015021-pol2qm74	4793	8	C	C	NNP
cord-015021-pol2qm74	4793	9	,	,	,
cord-015021-pol2qm74	4793	10	1Dransfield	1dransfield	JJ
cord-015021-pol2qm74	4793	11	I	-PRON-	PRP
cord-015021-pol2qm74	4793	12	,	,	,
cord-015021-pol2qm74	4793	13	2Robertson	2Robertson	NNP
cord-015021-pol2qm74	4793	14	CE	CE	NNP
cord-015021-pol2qm74	4793	15	,	,	,
cord-015021-pol2qm74	4793	16	3Grant	3grant	JJ
cord-015021-pol2qm74	4793	17	IS	be	VBZ
cord-015021-pol2qm74	4793	18	,	,	,
cord-015021-pol2qm74	4793	19	4Carter	4Carter	NNP
cord-015021-pol2qm74	4793	20	C	C	NNP
cord-015021-pol2qm74	4793	21	,	,	,
cord-015021-pol2qm74	4793	22	4Ross	4ross	CD
cord-015021-pol2qm74	4793	23	JA	JA	NNP
cord-015021-pol2qm74	4793	24	,	,	,
cord-015021-pol2qm74	4793	25	5Tedder	5Tedder	NNP
cord-015021-pol2qm74	4793	26	TF	TF	NNP
cord-015021-pol2qm74	4793	27	.	.	.
cord-015021-pol2qm74	4794	1	1Dept	1Dept	NNP
cord-015021-pol2qm74	4794	2	's	's	POS
cord-015021-pol2qm74	4794	3	of	of	IN
cord-015021-pol2qm74	4794	4	Respiratory	Respiratory	NNP
cord-015021-pol2qm74	4794	5	Medicine	Medicine	NNP
cord-015021-pol2qm74	4794	6	,	,	,
cord-015021-pol2qm74	4794	7	2Accident	2Accident	NNP
cord-015021-pol2qm74	4794	8	&	&	CC
cord-015021-pol2qm74	4794	9	Emergency	Emergency	NNP
cord-015021-pol2qm74	4794	10	,	,	,
cord-015021-pol2qm74	4794	11	3Intensive	3Intensive	NNP
cord-015021-pol2qm74	4794	12	Care	Care	NNP
cord-015021-pol2qm74	4794	13	,	,	,
cord-015021-pol2qm74	4794	14	4Surgery	4surgery	CD
cord-015021-pol2qm74	4794	15	,	,	,
cord-015021-pol2qm74	4794	16	University	University	NNP
cord-015021-pol2qm74	4794	17	of	of	IN
cord-015021-pol2qm74	4794	18	Edinburgh	Edinburgh	NNP
cord-015021-pol2qm74	4794	19	,	,	,
cord-015021-pol2qm74	4794	20	Scotland	Scotland	NNP
cord-015021-pol2qm74	4794	21	and	and	CC
cord-015021-pol2qm74	4794	22	5Dept	5Dept	NNP
cord-015021-pol2qm74	4794	23	.	.	.
cord-015021-pol2qm74	4795	1	Tumor	Tumor	NNP
cord-015021-pol2qm74	4795	2	Immunology	Immunology	NNP
cord-015021-pol2qm74	4795	3	,	,	,
cord-015021-pol2qm74	4795	4	Dana	Dana	NNP
cord-015021-pol2qm74	4795	5	Farber	Farber	NNP
cord-015021-pol2qm74	4795	6	Cancer	Cancer	NNP
cord-015021-pol2qm74	4795	7	Institute	Institute	NNP
cord-015021-pol2qm74	4795	8	,	,	,
cord-015021-pol2qm74	4795	9	Boston	Boston	NNP
cord-015021-pol2qm74	4795	10	.	.	.
cord-015021-pol2qm74	4796	1	The	the	DT
cord-015021-pol2qm74	4796	2	selectins	selectin	NNS
cord-015021-pol2qm74	4796	3	are	be	VBP
cord-015021-pol2qm74	4796	4	a	a	DT
cord-015021-pol2qm74	4796	5	family	family	NN
cord-015021-pol2qm74	4796	6	of	of	IN
cord-015021-pol2qm74	4796	7	adhesion	adhesion	NN
cord-015021-pol2qm74	4796	8	molecules	molecule	NNS
cord-015021-pol2qm74	4797	1	(	(	-LRB-
cord-015021-pol2qm74	4797	2	L	L	NNP
cord-015021-pol2qm74	4797	3	-	-	HYPH
cord-015021-pol2qm74	4797	4	selectin	selectin	NNP
cord-015021-pol2qm74	4797	5	,	,	,
cord-015021-pol2qm74	4797	6	E	e	NN
cord-015021-pol2qm74	4797	7	-	-	NN
cord-015021-pol2qm74	4797	8	selectin	selectin	JJ
cord-015021-pol2qm74	4797	9	,	,	,
cord-015021-pol2qm74	4797	10	Pselectin	Pselectin	NNP
cord-015021-pol2qm74	4797	11	)	)	-RRB-
cord-015021-pol2qm74	4797	12	,	,	,
cord-015021-pol2qm74	4797	13	all	all	DT
cord-015021-pol2qm74	4797	14	of	of	IN
cord-015021-pol2qm74	4797	15	whom	whom	WP
cord-015021-pol2qm74	4797	16	are	be	VBP
cord-015021-pol2qm74	4797	17	implicated	implicate	VBN
cord-015021-pol2qm74	4797	18	in	in	IN
cord-015021-pol2qm74	4797	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4797	20	cell	cell	NN
cord-015021-pol2qm74	4797	21	transendothelial	transendothelial	NN
cord-015021-pol2qm74	4797	22	migration	migration	NN
cord-015021-pol2qm74	4797	23	.	.	.
cord-015021-pol2qm74	4798	1	They	-PRON-	PRP
cord-015021-pol2qm74	4798	2	,	,	,
cord-015021-pol2qm74	4798	3	as	as	IN
cord-015021-pol2qm74	4798	4	a	a	DT
cord-015021-pol2qm74	4798	5	family	family	NN
cord-015021-pol2qm74	4798	6	can	can	MD
cord-015021-pol2qm74	4798	7	be	be	VB
cord-015021-pol2qm74	4798	8	proteolytieally	proteolytieally	RB
cord-015021-pol2qm74	4798	9	cleaved	cleave	VBN
cord-015021-pol2qm74	4798	10	from	from	IN
cord-015021-pol2qm74	4798	11	their	-PRON-	PRP$
cord-015021-pol2qm74	4798	12	parent	parent	NN
cord-015021-pol2qm74	4798	13	cell	cell	NN
cord-015021-pol2qm74	4798	14	and	and	CC
cord-015021-pol2qm74	4798	15	exist	exist	VBP
cord-015021-pol2qm74	4798	16	in	in	IN
cord-015021-pol2qm74	4798	17	a	a	DT
cord-015021-pol2qm74	4798	18	soluble	soluble	JJ
cord-015021-pol2qm74	4798	19	form	form	NN
cord-015021-pol2qm74	4798	20	within	within	IN
cord-015021-pol2qm74	4798	21	the	the	DT
cord-015021-pol2qm74	4798	22	circulation	circulation	NN
cord-015021-pol2qm74	4798	23	.	.	.
cord-015021-pol2qm74	4799	1	ARDS	ARDS	NNP
cord-015021-pol2qm74	4799	2	is	be	VBZ
cord-015021-pol2qm74	4799	3	a	a	DT
cord-015021-pol2qm74	4799	4	disease	disease	NN
cord-015021-pol2qm74	4799	5	state	state	NN
cord-015021-pol2qm74	4799	6	in	in	IN
cord-015021-pol2qm74	4799	7	whic	whic	JJ
cord-015021-pol2qm74	4799	8	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4799	9	and	and	CC
cord-015021-pol2qm74	4799	10	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4799	11	transendotheliat	transendotheliat	NNP
cord-015021-pol2qm74	4799	12	migration	migration	NN
cord-015021-pol2qm74	4799	13	have	have	VBP
cord-015021-pol2qm74	4799	14	been	be	VBN
cord-015021-pol2qm74	4799	15	implicated	implicate	VBN
cord-015021-pol2qm74	4799	16	.	.	.
cord-015021-pol2qm74	4800	1	In	in	IN
cord-015021-pol2qm74	4800	2	this	this	DT
cord-015021-pol2qm74	4800	3	study	study	NN
cord-015021-pol2qm74	4800	4	we	-PRON-	PRP
cord-015021-pol2qm74	4800	5	wished	wish	VBD
cord-015021-pol2qm74	4800	6	to	to	TO
cord-015021-pol2qm74	4800	7	investigate	investigate	VB
cord-015021-pol2qm74	4800	8	whether	whether	IN
cord-015021-pol2qm74	4800	9	the	the	DT
cord-015021-pol2qm74	4800	10	levels	level	NNS
cord-015021-pol2qm74	4800	11	of	of	IN
cord-015021-pol2qm74	4800	12	these	these	DT
cord-015021-pol2qm74	4800	13	circulating	circulate	VBG
cord-015021-pol2qm74	4800	14	soluble	soluble	JJ
cord-015021-pol2qm74	4800	15	receptors	receptor	NNS
cord-015021-pol2qm74	4800	16	from	from	IN
cord-015021-pol2qm74	4800	17	patients	patient	NNS
cord-015021-pol2qm74	4800	18	at	at	IN
cord-015021-pol2qm74	4800	19	-	-	HYPH
cord-015021-pol2qm74	4800	20	risk	risk	NN
cord-015021-pol2qm74	4800	21	of	of	IN
cord-015021-pol2qm74	4800	22	ARDS	ARDS	NNP
cord-015021-pol2qm74	4800	23	at	at	IN
cord-015021-pol2qm74	4800	24	initial	initial	JJ
cord-015021-pol2qm74	4800	25	hospital	hospital	NN
cord-015021-pol2qm74	4800	26	presentation	presentation	NN
cord-015021-pol2qm74	4800	27	,	,	,
cord-015021-pol2qm74	4800	28	correlated	correlate	VBN
cord-015021-pol2qm74	4800	29	with	with	IN
cord-015021-pol2qm74	4800	30	subsequent	subsequent	JJ
cord-015021-pol2qm74	4800	31	ARDS	ARDS	NNP
cord-015021-pol2qm74	4800	32	progression	progression	NN
cord-015021-pol2qm74	4800	33	.	.	.
cord-015021-pol2qm74	4801	1	Eighty	eighty	CD
cord-015021-pol2qm74	4801	2	-	-	HYPH
cord-015021-pol2qm74	4801	3	two	two	CD
cord-015021-pol2qm74	4801	4	patients	patient	NNS
cord-015021-pol2qm74	4801	5	were	be	VBD
cord-015021-pol2qm74	4801	6	enrolled	enrol	VBN
cord-015021-pol2qm74	4801	7	(	(	-LRB-
cord-015021-pol2qm74	4801	8	pancreatitis	pancreatitis	NNP
cord-015021-pol2qm74	4801	9	(	(	-LRB-
cord-015021-pol2qm74	4801	10	n=19	n=19	NNP
cord-015021-pol2qm74	4801	11	)	)	-RRB-
cord-015021-pol2qm74	4801	12	,	,	,
cord-015021-pol2qm74	4801	13	perforated	perforated	JJ
cord-015021-pol2qm74	4801	14	bowel	bowel	NN
cord-015021-pol2qm74	4801	15	(	(	-LRB-
cord-015021-pol2qm74	4801	16	n=12	n=12	NNP
cord-015021-pol2qm74	4801	17	)	)	-RRB-
cord-015021-pol2qm74	4801	18	,	,	,
cord-015021-pol2qm74	4801	19	and	and	CC
cord-015021-pol2qm74	4801	20	multiple	multiple	JJ
cord-015021-pol2qm74	4801	21	trauma	trauma	NN
cord-015021-pol2qm74	4801	22	(	(	-LRB-
cord-015021-pol2qm74	4801	23	n=51	n=51	NNP
cord-015021-pol2qm74	4801	24	)	)	-RRB-
cord-015021-pol2qm74	4801	25	)	)	-RRB-
cord-015021-pol2qm74	4801	26	,	,	,
cord-015021-pol2qm74	4801	27	of	of	IN
cord-015021-pol2qm74	4801	28	whom	whom	WP
cord-015021-pol2qm74	4801	29	14	14	CD
cord-015021-pol2qm74	4801	30	progressed	progress	VBD
cord-015021-pol2qm74	4801	31	to	to	IN
cord-015021-pol2qm74	4801	32	ARDS	ARDS	NNP
cord-015021-pol2qm74	4801	33	.	.	.
cord-015021-pol2qm74	4802	1	Assays	assay	NNS
cord-015021-pol2qm74	4802	2	for	for	IN
cord-015021-pol2qm74	4802	3	soluble	soluble	JJ
cord-015021-pol2qm74	4802	4	L	l	NN
cord-015021-pol2qm74	4802	5	,	,	,
cord-015021-pol2qm74	4802	6	P	p	NN
cord-015021-pol2qm74	4802	7	&	&	CC
cord-015021-pol2qm74	4802	8	E	E	NNP
cord-015021-pol2qm74	4802	9	-	-	NN
cord-015021-pol2qm74	4802	10	selectin	selectin	NNP
cord-015021-pol2qm74	4802	11	were	be	VBD
cord-015021-pol2qm74	4802	12	performed	perform	VBN
cord-015021-pol2qm74	4802	13	on	on	IN
cord-015021-pol2qm74	4802	14	collected	collect	VBN
cord-015021-pol2qm74	4802	15	plasma	plasma	NN
cord-015021-pol2qm74	4802	16	samples	sample	NNS
cord-015021-pol2qm74	4802	17	via	via	IN
cord-015021-pol2qm74	4802	18	a	a	DT
cord-015021-pol2qm74	4802	19	sandwich	sandwich	NN
cord-015021-pol2qm74	4802	20	ELISA	ELISA	NNP
cord-015021-pol2qm74	4802	21	.	.	.
cord-015021-pol2qm74	4803	1	(	(	-LRB-
cord-015021-pol2qm74	4803	2	NS	NS	NNP
cord-015021-pol2qm74	4803	3	=	=	NFP
cord-015021-pol2qm74	4803	4	Not	not	RB
cord-015021-pol2qm74	4803	5	significant	significant	JJ
cord-015021-pol2qm74	4803	6	,	,	,
cord-015021-pol2qm74	4804	1	*	*	NFP
cord-015021-pol2qm74	4804	2	*	*	NFP
cord-015021-pol2qm74	4804	3	*	*	NFP
cord-015021-pol2qm74	4804	4	*	*	NFP
cord-015021-pol2qm74	4804	5	=	=	SYM
cord-015021-pol2qm74	4804	6	p	p	NN
cord-015021-pol2qm74	4804	7	<	<	XX
cord-015021-pol2qm74	4804	8	O.0001	O.0001	NNP
cord-015021-pol2qm74	4804	9	)	)	-RRB-
cord-015021-pol2qm74	4805	1	We	-PRON-	PRP
cord-015021-pol2qm74	4805	2	have	have	VBP
cord-015021-pol2qm74	4805	3	found	find	VBN
cord-015021-pol2qm74	4805	4	a	a	DT
cord-015021-pol2qm74	4805	5	highly	highly	RB
cord-015021-pol2qm74	4805	6	significant	significant	JJ
cord-015021-pol2qm74	4805	7	inverse	inverse	JJ
cord-015021-pol2qm74	4805	8	correlation	correlation	NN
cord-015021-pol2qm74	4805	9	between	between	IN
cord-015021-pol2qm74	4805	10	a	a	DT
cord-015021-pol2qm74	4805	11	low	low	JJ
cord-015021-pol2qm74	4805	12	circulating	circulate	VBG
cord-015021-pol2qm74	4805	13	soluble	soluble	JJ
cord-015021-pol2qm74	4805	14	L	l	NN
cord-015021-pol2qm74	4805	15	-	-	HYPH
cord-015021-pol2qm74	4805	16	selectin	selectin	NNP
cord-015021-pol2qm74	4805	17	(	(	-LRB-
cord-015021-pol2qm74	4805	18	and	and	CC
cord-015021-pol2qm74	4805	19	not	not	RB
cord-015021-pol2qm74	4805	20	soluble	soluble	JJ
cord-015021-pol2qm74	4805	21	E	e	NN
cord-015021-pol2qm74	4805	22	&	&	CC
cord-015021-pol2qm74	4805	23	P	P	NNP
cord-015021-pol2qm74	4805	24	-	-	HYPH
cord-015021-pol2qm74	4805	25	selectin	selectin	NNP
cord-015021-pol2qm74	4805	26	)	)	-RRB-
cord-015021-pol2qm74	4805	27	and	and	CC
cord-015021-pol2qm74	4805	28	subsequent	subsequent	JJ
cord-015021-pol2qm74	4805	29	ARDS	ARDS	NNP
cord-015021-pol2qm74	4805	30	.	.	.
cord-015021-pol2qm74	4806	1	These	these	DT
cord-015021-pol2qm74	4806	2	results	result	NNS
cord-015021-pol2qm74	4806	3	further	far	RBR
cord-015021-pol2qm74	4806	4	our	-PRON-	PRP$
cord-015021-pol2qm74	4806	5	understanding	understanding	NN
cord-015021-pol2qm74	4806	6	of	of	IN
cord-015021-pol2qm74	4806	7	neutrophilendothelial	neutrophilendothelial	JJ
cord-015021-pol2qm74	4806	8	interactions	interaction	NNS
cord-015021-pol2qm74	4806	9	in	in	IN
cord-015021-pol2qm74	4806	10	the	the	DT
cord-015021-pol2qm74	4806	11	early	early	JJ
cord-015021-pol2qm74	4806	12	stages	stage	NNS
cord-015021-pol2qm74	4806	13	of	of	IN
cord-015021-pol2qm74	4806	14	ARDS	ARDS	NNP
cord-015021-pol2qm74	4806	15	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	4806	16	and	and	CC
cord-015021-pol2qm74	4806	17	offer	offer	VBP
cord-015021-pol2qm74	4806	18	the	the	DT
cord-015021-pol2qm74	4806	19	promise	promise	NN
cord-015021-pol2qm74	4806	20	of	of	IN
cord-015021-pol2qm74	4806	21	sL	sL	NNS
cord-015021-pol2qm74	4806	22	-	-	:
cord-015021-pol2qm74	4806	23	selectin	selectin	NN
cord-015021-pol2qm74	4806	24	in	in	IN
cord-015021-pol2qm74	4806	25	combination	combination	NN
cord-015021-pol2qm74	4806	26	with	with	IN
cord-015021-pol2qm74	4806	27	other	other	JJ
cord-015021-pol2qm74	4806	28	markers	marker	NNS
cord-015021-pol2qm74	4806	29	of	of	IN
cord-015021-pol2qm74	4806	30	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4806	31	events	event	NNS
cord-015021-pol2qm74	4806	32	being	be	VBG
cord-015021-pol2qm74	4806	33	used	use	VBN
cord-015021-pol2qm74	4806	34	to	to	TO
cord-015021-pol2qm74	4806	35	identify	identify	VB
cord-015021-pol2qm74	4806	36	individuals	individual	NNS
cord-015021-pol2qm74	4806	37	at	at	IN
cord-015021-pol2qm74	4806	38	particularly	particularly	RB
cord-015021-pol2qm74	4806	39	high	high	JJ
cord-015021-pol2qm74	4806	40	risk	risk	NN
cord-015021-pol2qm74	4806	41	of	of	IN
cord-015021-pol2qm74	4806	42	ARDS	ARDS	NNP
cord-015021-pol2qm74	4806	43	progression	progression	NN
cord-015021-pol2qm74	4806	44	on	on	IN
cord-015021-pol2qm74	4806	45	initial	initial	JJ
cord-015021-pol2qm74	4806	46	hospital	hospital	NN
cord-015021-pol2qm74	4806	47	presentation	presentation	NN
cord-015021-pol2qm74	4806	48	.	.	.
cord-015021-pol2qm74	4807	1	It	-PRON-	PRP
cord-015021-pol2qm74	4807	2	has	have	VBZ
cord-015021-pol2qm74	4807	3	been	be	VBN
cord-015021-pol2qm74	4807	4	suggested	suggest	VBN
cord-015021-pol2qm74	4807	5	that	that	IN
cord-015021-pol2qm74	4807	6	polymorphonuclear	polymorphonuclear	NNP
cord-015021-pol2qm74	4807	7	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	4807	8	aggregate	aggregate	VBP
cord-015021-pol2qm74	4807	9	in	in	IN
cord-015021-pol2qm74	4807	10	the	the	DT
cord-015021-pol2qm74	4807	11	lung	lung	NN
cord-015021-pol2qm74	4807	12	capillaries	capillary	NNS
cord-015021-pol2qm74	4807	13	of	of	IN
cord-015021-pol2qm74	4807	14	patients	patient	NNS
cord-015021-pol2qm74	4807	15	developing	develop	VBG
cord-015021-pol2qm74	4807	16	the	the	DT
cord-015021-pol2qm74	4807	17	adult	adult	NN
cord-015021-pol2qm74	4807	18	respiratory	respiratory	JJ
cord-015021-pol2qm74	4807	19	distress	distress	NN
cord-015021-pol2qm74	4807	20	syndrome	syndrome	NN
cord-015021-pol2qm74	4807	21	(	(	-LRB-
cord-015021-pol2qm74	4807	22	ARDS	ARDS	NNP
cord-015021-pol2qm74	4807	23	)	)	-RRB-
cord-015021-pol2qm74	4807	24	and	and	CC
cord-015021-pol2qm74	4807	25	account	account	VB
cord-015021-pol2qm74	4807	26	for	for	IN
cord-015021-pol2qm74	4807	27	the	the	DT
cord-015021-pol2qm74	4807	28	endothelial	endothelial	JJ
cord-015021-pol2qm74	4807	29	damage	damage	NN
cord-015021-pol2qm74	4807	30	while	while	IN
cord-015021-pol2qm74	4807	31	releasing	release	VBG
cord-015021-pol2qm74	4807	32	toxic	toxic	JJ
cord-015021-pol2qm74	4807	33	metabo	metabo	NNP
cord-015021-pol2qm74	4807	34	-	-	:
cord-015021-pol2qm74	4807	35	Iites	Iites	NNPS
cord-015021-pol2qm74	4807	36	such	such	JJ
cord-015021-pol2qm74	4807	37	as	as	IN
cord-015021-pol2qm74	4807	38	o.a	o.a	NNP
cord-015021-pol2qm74	4807	39	.	.	NNP
cord-015021-pol2qm74	4807	40	free	free	JJ
cord-015021-pol2qm74	4807	41	oxygen	oxygen	NN
cord-015021-pol2qm74	4807	42	radicals	radical	NNS
cord-015021-pol2qm74	4807	43	.	.	.
cord-015021-pol2qm74	4808	1	Among	among	IN
cord-015021-pol2qm74	4808	2	many	many	JJ
cord-015021-pol2qm74	4808	3	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	4808	4	which	which	WDT
cord-015021-pol2qm74	4808	5	have	have	VBP
cord-015021-pol2qm74	4808	6	been	be	VBN
cord-015021-pol2qm74	4808	7	investigated	investigate	VBN
cord-015021-pol2qm74	4808	8	in	in	IN
cord-015021-pol2qm74	4808	9	in	in	FW
cord-015021-pol2qm74	4808	10	vitro	vitro	FW
cord-015021-pol2qm74	4808	11	systems	system	NNS
cord-015021-pol2qm74	4808	12	and	and	CC
cord-015021-pol2qm74	4808	13	in	in	IN
cord-015021-pol2qm74	4808	14	animal	animal	NN
cord-015021-pol2qm74	4808	15	models	model	NNS
cord-015021-pol2qm74	4808	16	,	,	,
cord-015021-pol2qm74	4808	17	N	n	NN
cord-015021-pol2qm74	4808	18	-	-	HYPH
cord-015021-pol2qm74	4808	19	acetylcysteine	acetylcysteine	NN
cord-015021-pol2qm74	4808	20	(	(	-LRB-
cord-015021-pol2qm74	4808	21	NAC	NAC	NNP
cord-015021-pol2qm74	4808	22	)	)	-RRB-
cord-015021-pol2qm74	4808	23	has	have	VBZ
cord-015021-pol2qm74	4808	24	been	be	VBN
cord-015021-pol2qm74	4808	25	established	establish	VBN
cord-015021-pol2qm74	4808	26	to	to	TO
cord-015021-pol2qm74	4808	27	be	be	VB
cord-015021-pol2qm74	4808	28	useful	useful	JJ
cord-015021-pol2qm74	4808	29	as	as	IN
cord-015021-pol2qm74	4808	30	a	a	DT
cord-015021-pol2qm74	4808	31	free	free	JJ
cord-015021-pol2qm74	4808	32	radical	radical	JJ
cord-015021-pol2qm74	4808	33	scavenger	scavenger	NN
cord-015021-pol2qm74	4808	34	in	in	IN
cord-015021-pol2qm74	4808	35	vivo	vivo	NNP
cord-015021-pol2qm74	4808	36	.	.	.
cord-015021-pol2qm74	4809	1	To	to	TO
cord-015021-pol2qm74	4809	2	assess	assess	VB
cord-015021-pol2qm74	4809	3	the	the	DT
cord-015021-pol2qm74	4809	4	influence	influence	NN
cord-015021-pol2qm74	4809	5	of	of	IN
cord-015021-pol2qm74	4809	6	N	n	NN
cord-015021-pol2qm74	4809	7	-	-	HYPH
cord-015021-pol2qm74	4809	8	acetylcysteine	acetylcysteine	NN
cord-015021-pol2qm74	4809	9	(	(	-LRB-
cord-015021-pol2qm74	4809	10	NAC	NAC	NNP
cord-015021-pol2qm74	4809	11	)	)	-RRB-
cord-015021-pol2qm74	4809	12	on	on	IN
cord-015021-pol2qm74	4809	13	the	the	DT
cord-015021-pol2qm74	4809	14	activation	activation	NN
cord-015021-pol2qm74	4809	15	of	of	IN
cord-015021-pol2qm74	4809	16	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4809	17	in	in	IN
cord-015021-pol2qm74	4809	18	patients	patient	NNS
cord-015021-pol2qm74	4809	19	undergoing	undergo	VBG
cord-015021-pol2qm74	4809	20	cardiopulmonary	cardiopulmonary	JJ
cord-015021-pol2qm74	4809	21	bypass	bypass	NN
cord-015021-pol2qm74	4809	22	(	(	-LRB-
cord-015021-pol2qm74	4809	23	CPB	CPB	NNP
cord-015021-pol2qm74	4809	24	)	)	-RRB-
cord-015021-pol2qm74	4809	25	surgery	surgery	NN
cord-015021-pol2qm74	4809	26	with	with	IN
cord-015021-pol2qm74	4809	27	extracorporeal	extracorporeal	JJ
cord-015021-pol2qm74	4809	28	circulation	circulation	NN
cord-015021-pol2qm74	4809	29	(	(	-LRB-
cord-015021-pol2qm74	4809	30	ECC	ECC	NNP
cord-015021-pol2qm74	4809	31	)	)	-RRB-
cord-015021-pol2qm74	4809	32	,	,	,
cord-015021-pol2qm74	4809	33	we	-PRON-	PRP
cord-015021-pol2qm74	4809	34	evaluated	evaluate	VBD
cord-015021-pol2qm74	4809	35	the	the	DT
cord-015021-pol2qm74	4809	36	plasma	plasma	NN
cord-015021-pol2qm74	4809	37	levels	level	NNS
cord-015021-pol2qm74	4809	38	of	of	IN
cord-015021-pol2qm74	4809	39	elastase	elastase	NN
cord-015021-pol2qm74	4809	40	and	and	CC
cord-015021-pol2qm74	4809	41	myeloperoxidase	myeloperoxidase	NNP
cord-015021-pol2qm74	4809	42	(	(	-LRB-
cord-015021-pol2qm74	4809	43	MPO	MPO	NNP
cord-015021-pol2qm74	4809	44	)	)	-RRB-
cord-015021-pol2qm74	4809	45	throughout	throughout	IN
cord-015021-pol2qm74	4809	46	the	the	DT
cord-015021-pol2qm74	4809	47	operation	operation	NN
cord-015021-pol2qm74	4809	48	and	and	CC
cord-015021-pol2qm74	4809	49	up	up	IN
cord-015021-pol2qm74	4809	50	to	to	TO
cord-015021-pol2qm74	4809	51	24	24	CD
cord-015021-pol2qm74	4809	52	hours	hour	NNS
cord-015021-pol2qm74	4809	53	after	after	IN
cord-015021-pol2qm74	4809	54	surgery	surgery	NN
cord-015021-pol2qm74	4809	55	.	.	.
cord-015021-pol2qm74	4810	1	Four	four	CD
cord-015021-pol2qm74	4810	2	hours	hour	NNS
cord-015021-pol2qm74	4810	3	after	after	IN
cord-015021-pol2qm74	4810	4	surgery	surgery	NN
cord-015021-pol2qm74	4810	5	also	also	RB
cord-015021-pol2qm74	4810	6	a	a	DT
cord-015021-pol2qm74	4810	7	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	4810	8	lavage	lavage	NN
cord-015021-pol2qm74	4810	9	was	be	VBD
cord-015021-pol2qm74	4810	10	performed	perform	VBN
cord-015021-pol2qm74	4810	11	.	.	.
cord-015021-pol2qm74	4811	1	A	a	DT
cord-015021-pol2qm74	4811	2	spectrophotometric	spectrophotometric	JJ
cord-015021-pol2qm74	4811	3	method	method	NN
cord-015021-pol2qm74	4811	4	was	be	VBD
cord-015021-pol2qm74	4811	5	used	use	VBN
cord-015021-pol2qm74	4811	6	for	for	IN
cord-015021-pol2qm74	4811	7	the	the	DT
cord-015021-pol2qm74	4811	8	detection	detection	NN
cord-015021-pol2qm74	4811	9	of	of	IN
cord-015021-pol2qm74	4811	10	plasma	plasma	NN
cord-015021-pol2qm74	4811	11	elastase	elastase	NN
cord-015021-pol2qm74	4811	12	activity	activity	NN
cord-015021-pol2qm74	4811	13	and	and	CC
cord-015021-pol2qm74	4811	14	MPO	MPO	NNP
cord-015021-pol2qm74	4811	15	levels	level	NNS
cord-015021-pol2qm74	4811	16	were	be	VBD
cord-015021-pol2qm74	4811	17	measured	measure	VBN
cord-015021-pol2qm74	4811	18	using	use	VBG
cord-015021-pol2qm74	4811	19	a	a	DT
cord-015021-pol2qm74	4811	20	radioimmunoassay	radioimmunoassay	NN
cord-015021-pol2qm74	4811	21	.	.	.
cord-015021-pol2qm74	4812	1	We	-PRON-	PRP
cord-015021-pol2qm74	4812	2	found	find	VBD
cord-015021-pol2qm74	4812	3	that	that	DT
cord-015021-pol2qm74	4812	4	pretreatment	pretreatment	NN
cord-015021-pol2qm74	4812	5	with	with	IN
cord-015021-pol2qm74	4812	6	intravenous	intravenous	JJ
cord-015021-pol2qm74	4812	7	NAC	NAC	NNP
cord-015021-pol2qm74	4812	8	prevented	prevent	VBD
cord-015021-pol2qm74	4812	9	the	the	DT
cord-015021-pol2qm74	4812	10	increase	increase	NN
cord-015021-pol2qm74	4812	11	in	in	IN
cord-015021-pol2qm74	4812	12	elastase	elastase	NN
cord-015021-pol2qm74	4812	13	activity	activity	NN
cord-015021-pol2qm74	4812	14	(	(	-LRB-
cord-015021-pol2qm74	4812	15	632	632	CD
cord-015021-pol2qm74	4812	16	_	_	NN
cord-015021-pol2qm74	4812	17	+	+	SYM
cord-015021-pol2qm74	4812	18	231	231	CD
cord-015021-pol2qm74	4812	19	pmol	pmol	NN
cord-015021-pol2qm74	4812	20	/	/	,
cord-015021-pol2qm74	4812	21	I	-PRON-	PRP
cord-015021-pol2qm74	4812	22	vs	vs	IN
cord-015021-pol2qm74	4812	23	1666	1666	CD
cord-015021-pol2qm74	4813	1	_	_	NN
cord-015021-pol2qm74	4813	2	+	+	SYM
cord-015021-pol2qm74	4813	3	187	187	CD
cord-015021-pol2qm74	4813	4	;	;	:
cord-015021-pol2qm74	4813	5	P	p	NN
cord-015021-pol2qm74	4813	6	-0.027	-0.027	NNP
cord-015021-pol2qm74	4813	7	)	)	-RRB-
cord-015021-pol2qm74	4813	8	,	,	,
cord-015021-pol2qm74	4813	9	but	but	CC
cord-015021-pol2qm74	4813	10	not	not	RB
cord-015021-pol2qm74	4813	11	the	the	DT
cord-015021-pol2qm74	4813	12	release	release	NN
cord-015021-pol2qm74	4813	13	of	of	IN
cord-015021-pol2qm74	4813	14	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4813	15	related	related	JJ
cord-015021-pol2qm74	4813	16	mediators	mediator	NNS
cord-015021-pol2qm74	4813	17	(	(	-LRB-
cord-015021-pol2qm74	4814	1	2.20	2.20	CD
cord-015021-pol2qm74	4814	2	_	_	NN
cord-015021-pol2qm74	4814	3	+	+	CC
cord-015021-pol2qm74	4815	1	0.56	0.56	CD
cord-015021-pol2qm74	4815	2	ng	ng	NNP
cord-015021-pol2qm74	4815	3	/	/	SYM
cord-015021-pol2qm74	4815	4	I	-PRON-	PRP
cord-015021-pol2qm74	4815	5	vs	vs	IN
cord-015021-pol2qm74	4816	1	1.80	1.80	CD
cord-015021-pol2qm74	4816	2	_	_	NN
cord-015021-pol2qm74	4816	3	+	+	SYM
cord-015021-pol2qm74	4816	4	0.17	0.17	CD
cord-015021-pol2qm74	4816	5	;	;	:
cord-015021-pol2qm74	4816	6	P=0.63	P=0.63	NNP
cord-015021-pol2qm74	4816	7	)	)	-RRB-
cord-015021-pol2qm74	4816	8	.	.	.
cord-015021-pol2qm74	4817	1	Besides	besides	RB
cord-015021-pol2qm74	4817	2	,	,	,
cord-015021-pol2qm74	4817	3	NAC	NAC	NNP
cord-015021-pol2qm74	4817	4	had	have	VBD
cord-015021-pol2qm74	4817	5	the	the	DT
cord-015021-pol2qm74	4817	6	capability	capability	NN
cord-015021-pol2qm74	4817	7	to	to	TO
cord-015021-pol2qm74	4817	8	prevent	prevent	VB
cord-015021-pol2qm74	4817	9	the	the	DT
cord-015021-pol2qm74	4817	10	enhancement	enhancement	NN
cord-015021-pol2qm74	4817	11	of	of	IN
cord-015021-pol2qm74	4817	12	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4817	13	numbers	number	NNS
cord-015021-pol2qm74	4817	14	in	in	IN
cord-015021-pol2qm74	4817	15	lavage	lavage	NN
cord-015021-pol2qm74	4817	16	fluid	fluid	NN
cord-015021-pol2qm74	4817	17	as	as	IN
cord-015021-pol2qm74	4817	18	is	be	VBZ
cord-015021-pol2qm74	4817	19	normally	normally	RB
cord-015021-pol2qm74	4817	20	seen	see	VBN
cord-015021-pol2qm74	4817	21	during	during	IN
cord-015021-pol2qm74	4817	22	CPB	CPB	NNP
cord-015021-pol2qm74	4817	23	(	(	-LRB-
cord-015021-pol2qm74	4817	24	1.4	1.4	CD
cord-015021-pol2qm74	4817	25	+	+	SYM
cord-015021-pol2qm74	4817	26	0.8	0.8	CD
cord-015021-pol2qm74	4817	27	%	%	NN
cord-015021-pol2qm74	4817	28	vs	vs	IN
cord-015021-pol2qm74	4818	1	25.0	25.0	CD
cord-015021-pol2qm74	4818	2	_	_	NN
cord-015021-pol2qm74	4818	3	+	+	SYM
cord-015021-pol2qm74	4818	4	14.3	14.3	CD
cord-015021-pol2qm74	4818	5	;	;	:
cord-015021-pol2qm74	4818	6	P	p	NN
cord-015021-pol2qm74	4818	7	=	=	SYM
cord-015021-pol2qm74	4818	8	0.04	0.04	CD
cord-015021-pol2qm74	4818	9	)	)	-RRB-
cord-015021-pol2qm74	4818	10	.	.	.
cord-015021-pol2qm74	4819	1	Although	although	IN
cord-015021-pol2qm74	4819	2	not	not	RB
cord-015021-pol2qm74	4819	3	significant	significant	JJ
cord-015021-pol2qm74	4819	4	,	,	,
cord-015021-pol2qm74	4819	5	NAC	NAC	NNP
cord-015021-pol2qm74	4819	6	prevented	prevent	VBD
cord-015021-pol2qm74	4819	7	also	also	RB
cord-015021-pol2qm74	4819	8	the	the	DT
cord-015021-pol2qm74	4819	9	increase	increase	NN
cord-015021-pol2qm74	4819	10	in	in	IN
cord-015021-pol2qm74	4819	11	elastase	elastase	NN
cord-015021-pol2qm74	4819	12	levels	level	NNS
cord-015021-pol2qm74	4819	13	in	in	IN
cord-015021-pol2qm74	4819	14	lavage	lavage	NN
cord-015021-pol2qm74	4819	15	fluid	fluid	NN
cord-015021-pol2qm74	4819	16	(	(	-LRB-
cord-015021-pol2qm74	4819	17	19.0	19.0	CD
cord-015021-pol2qm74	4819	18	+	+	SYM
cord-015021-pol2qm74	4819	19	18.5	18.5	CD
cord-015021-pol2qm74	4819	20	pmol	pmol	NNP
cord-015021-pol2qm74	4819	21	/	/	,
cord-015021-pol2qm74	4819	22	I	-PRON-	PRP
cord-015021-pol2qm74	4819	23	vs	vs	IN
cord-015021-pol2qm74	4819	24	172.7	172.7	CD
cord-015021-pol2qm74	4819	25	+	+	SYM
cord-015021-pol2qm74	4819	26	101.4	101.4	CD
cord-015021-pol2qm74	4819	27	;	;	:
cord-015021-pol2qm74	4819	28	P	p	NN
cord-015021-pol2qm74	4819	29	=	=	SYM
cord-015021-pol2qm74	4819	30	0.12	0.12	CD
cord-015021-pol2qm74	4819	31	)	)	-RRB-
cord-015021-pol2qm74	4819	32	.	.	.
cord-015021-pol2qm74	4820	1	It	-PRON-	PRP
cord-015021-pol2qm74	4820	2	is	be	VBZ
cord-015021-pol2qm74	4820	3	concluded	conclude	VBN
cord-015021-pol2qm74	4820	4	that	that	IN
cord-015021-pol2qm74	4820	5	NAC	NAC	NNP
cord-015021-pol2qm74	4820	6	is	be	VBZ
cord-015021-pol2qm74	4820	7	able	able	JJ
cord-015021-pol2qm74	4820	8	to	to	TO
cord-015021-pol2qm74	4820	9	protect	protect	VB
cord-015021-pol2qm74	4820	10	against	against	IN
cord-015021-pol2qm74	4820	11	the	the	DT
cord-015021-pol2qm74	4820	12	inactivation	inactivation	NN
cord-015021-pol2qm74	4820	13	of	of	IN
cord-015021-pol2qm74	4820	14	a	a	DT
cord-015021-pol2qm74	4820	15	1-proteinase	1-proteinase	CD
cord-015021-pol2qm74	4820	16	inhibitor	inhibitor	NN
cord-015021-pol2qm74	4820	17	,	,	,
cord-015021-pol2qm74	4820	18	the	the	DT
cord-015021-pol2qm74	4820	19	main	main	JJ
cord-015021-pol2qm74	4820	20	inhibitor	inhibitor	NN
cord-015021-pol2qm74	4820	21	of	of	IN
cord-015021-pol2qm74	4820	22	elastase	elastase	NN
cord-015021-pol2qm74	4820	23	activity	activity	NN
cord-015021-pol2qm74	4820	24	,	,	,
cord-015021-pol2qm74	4820	25	and	and	CC
cord-015021-pol2qm74	4820	26	that	that	IN
cord-015021-pol2qm74	4820	27	NAC	NAC	NNP
cord-015021-pol2qm74	4820	28	interferes	interfere	VBZ
cord-015021-pol2qm74	4820	29	with	with	IN
cord-015021-pol2qm74	4820	30	adhesion	adhesion	NN
cord-015021-pol2qm74	4820	31	and	and	CC
cord-015021-pol2qm74	4820	32	migration	migration	NN
cord-015021-pol2qm74	4820	33	of	of	IN
cord-015021-pol2qm74	4820	34	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4820	35	.	.	.
cord-015021-pol2qm74	4821	1	Therefore	therefore	RB
cord-015021-pol2qm74	4821	2	NAC	NAC	NNP
cord-015021-pol2qm74	4821	3	may	may	MD
cord-015021-pol2qm74	4821	4	be	be	VB
cord-015021-pol2qm74	4821	5	useful	useful	JJ
cord-015021-pol2qm74	4821	6	in	in	IN
cord-015021-pol2qm74	4821	7	the	the	DT
cord-015021-pol2qm74	4821	8	prevention	prevention	NN
cord-015021-pol2qm74	4821	9	of	of	IN
cord-015021-pol2qm74	4821	10	tissue	tissue	NN
cord-015021-pol2qm74	4821	11	damage	damage	NN
cord-015021-pol2qm74	4821	12	.	.	.
cord-015021-pol2qm74	4822	1	This	this	DT
cord-015021-pol2qm74	4822	2	study	study	NN
cord-015021-pol2qm74	4822	3	is	be	VBZ
cord-015021-pol2qm74	4822	4	supported	support	VBN
cord-015021-pol2qm74	4822	5	by	by	IN
cord-015021-pol2qm74	4822	6	Inpharzam	Inpharzam	NNP
cord-015021-pol2qm74	4822	7	Belgium	Belgium	NNP
cord-015021-pol2qm74	4822	8	.	.	.
cord-015021-pol2qm74	4823	1	Sodium	sodium	NN
cord-015021-pol2qm74	4823	2	nitroprnsside	nitroprnsside	NN
cord-015021-pol2qm74	4823	3	(	(	-LRB-
cord-015021-pol2qm74	4823	4	SNP	SNP	NNP
cord-015021-pol2qm74	4823	5	)	)	-RRB-
cord-015021-pol2qm74	4823	6	has	have	VBZ
cord-015021-pol2qm74	4823	7	previously	previously	RB
cord-015021-pol2qm74	4823	8	been	be	VBN
cord-015021-pol2qm74	4823	9	shown	show	VBN
cord-015021-pol2qm74	4823	10	to	to	TO
cord-015021-pol2qm74	4823	11	attenuate	attenuate	VB
cord-015021-pol2qm74	4823	12	the	the	DT
cord-015021-pol2qm74	4823	13	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4823	14	induced	induce	VBN
cord-015021-pol2qm74	4823	15	lung	lung	NN
cord-015021-pol2qm74	4823	16	injury	injury	NN
cord-015021-pol2qm74	4823	17	associated	associate	VBN
cord-015021-pol2qm74	4823	18	with	with	IN
cord-015021-pol2qm74	4823	19	limb	limb	NN
cord-015021-pol2qm74	4823	20	ischaemia	ischaemia	NN
cord-015021-pol2qm74	4823	21	and	and	CC
cord-015021-pol2qm74	4823	22	repeffusion	repeffusion	NN
cord-015021-pol2qm74	4823	23	.	.	.
cord-015021-pol2qm74	4824	1	Glyceryl	Glyceryl	NNP
cord-015021-pol2qm74	4824	2	Trinitrate	Trinitrate	NNP
cord-015021-pol2qm74	4824	3	(	(	-LRB-
cord-015021-pol2qm74	4824	4	GTN	GTN	NNP
cord-015021-pol2qm74	4824	5	)	)	-RRB-
cord-015021-pol2qm74	4824	6	,	,	,
cord-015021-pol2qm74	4824	7	already	already	RB
cord-015021-pol2qm74	4824	8	widely	widely	RB
cord-015021-pol2qm74	4824	9	used	use	VBN
cord-015021-pol2qm74	4824	10	in	in	IN
cord-015021-pol2qm74	4824	11	aortic	aortic	JJ
cord-015021-pol2qm74	4824	12	surgery	surgery	NN
cord-015021-pol2qm74	4824	13	,	,	,
cord-015021-pol2qm74	4824	14	also	also	RB
cord-015021-pol2qm74	4824	15	increases	increase	VBZ
cord-015021-pol2qm74	4824	16	nitric	nitric	JJ
cord-015021-pol2qm74	4824	17	oxide	oxide	NN
cord-015021-pol2qm74	4824	18	but	but	CC
cord-015021-pol2qm74	4824	19	has	have	VBZ
cord-015021-pol2qm74	4824	20	a	a	DT
cord-015021-pol2qm74	4824	21	less	less	RBR
cord-015021-pol2qm74	4824	22	marked	marked	JJ
cord-015021-pol2qm74	4824	23	splanchnic	splanchnic	JJ
cord-015021-pol2qm74	4824	24	"	"	``
cord-015021-pol2qm74	4824	25	steal	steal	VB
cord-015021-pol2qm74	4824	26	"	"	''
cord-015021-pol2qm74	4824	27	effect	effect	NN
cord-015021-pol2qm74	4824	28	.	.	.
cord-015021-pol2qm74	4825	1	We	-PRON-	PRP
cord-015021-pol2qm74	4825	2	examined	examine	VBD
cord-015021-pol2qm74	4825	3	the	the	DT
cord-015021-pol2qm74	4825	4	effect	effect	NN
cord-015021-pol2qm74	4825	5	of	of	IN
cord-015021-pol2qm74	4825	6	GTN	GTN	NNP
cord-015021-pol2qm74	4825	7	on	on	IN
cord-015021-pol2qm74	4825	8	lung	lung	NN
cord-015021-pol2qm74	4825	9	injury	injury	NN
cord-015021-pol2qm74	4825	10	,	,	,
cord-015021-pol2qm74	4825	11	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4825	12	infiltration	infiltration	NN
cord-015021-pol2qm74	4825	13	and	and	CC
cord-015021-pol2qm74	4825	14	activation	activation	NN
cord-015021-pol2qm74	4825	15	in	in	IN
cord-015021-pol2qm74	4825	16	a	a	DT
cord-015021-pol2qm74	4825	17	model	model	NN
cord-015021-pol2qm74	4825	18	of	of	IN
cord-015021-pol2qm74	4825	19	aortic	aortic	JJ
cord-015021-pol2qm74	4825	20	occlusion	occlusion	NN
cord-015021-pol2qm74	4825	21	(	(	-LRB-
cord-015021-pol2qm74	4825	22	30	30	CD
cord-015021-pol2qm74	4825	23	rain	rain	NN
cord-015021-pol2qm74	4825	24	)	)	-RRB-
cord-015021-pol2qm74	4825	25	and	and	CC
cord-015021-pol2qm74	4825	26	repeffusion	repeffusion	NN
cord-015021-pol2qm74	4825	27	(	(	-LRB-
cord-015021-pol2qm74	4825	28	120	120	CD
cord-015021-pol2qm74	4825	29	min	min	NN
cord-015021-pol2qm74	4825	30	)	)	-RRB-
cord-015021-pol2qm74	4825	31	.	.	.
cord-015021-pol2qm74	4826	1	Sprague	Sprague	NNP
cord-015021-pol2qm74	4826	2	Dawley	Dawley	NNP
cord-015021-pol2qm74	4826	3	rats	rat	NNS
cord-015021-pol2qm74	4826	4	were	be	VBD
cord-015021-pol2qm74	4826	5	randomized	randomize	VBN
cord-015021-pol2qm74	4826	6	into	into	IN
cord-015021-pol2qm74	4826	7	:	:	:
cord-015021-pol2qm74	4826	8	control	control	NN
cord-015021-pol2qm74	4826	9	(	(	-LRB-
cord-015021-pol2qm74	4826	10	N	n	NN
cord-015021-pol2qm74	4826	11	=	=	SYM
cord-015021-pol2qm74	4826	12	I	i	NN
cord-015021-pol2qm74	4826	13	1	1	CD
cord-015021-pol2qm74	4826	14	)	)	-RRB-
cord-015021-pol2qm74	4826	15	;	;	:
cord-015021-pol2qm74	4826	16	ischaemia	ischaemia	NN
cord-015021-pol2qm74	4826	17	repeffusion	repeffusion	NN
cord-015021-pol2qm74	4826	18	(	(	-LRB-
cord-015021-pol2qm74	4826	19	IR	IR	NNP
cord-015021-pol2qm74	4826	20	)	)	-RRB-
cord-015021-pol2qm74	4826	21	(	(	-LRB-
cord-015021-pol2qm74	4826	22	N=12	N=12	NNP
cord-015021-pol2qm74	4826	23	)	)	-RRB-
cord-015021-pol2qm74	4826	24	;	;	:
cord-015021-pol2qm74	4826	25	and	and	CC
cord-015021-pol2qm74	4826	26	IR	IR	NNP
cord-015021-pol2qm74	4826	27	treated	treat	VBN
cord-015021-pol2qm74	4826	28	with	with	IN
cord-015021-pol2qm74	4826	29	GTN	GTN	NNP
cord-015021-pol2qm74	4826	30	(	(	-LRB-
cord-015021-pol2qm74	4826	31	2ug	2ug	NNP
cord-015021-pol2qm74	4826	32	/	/	SYM
cord-015021-pol2qm74	4826	33	kg	kg	NN
cord-015021-pol2qm74	4826	34	/	/	SYM
cord-015021-pol2qm74	4826	35	min	min	NN
cord-015021-pol2qm74	4826	36	)	)	-RRB-
cord-015021-pol2qm74	4826	37	during	during	IN
cord-015021-pol2qm74	4826	38	repeffusion	repeffusion	NN
cord-015021-pol2qm74	4826	39	(	(	-LRB-
cord-015021-pol2qm74	4826	40	N=10	N=10	NNP
cord-015021-pol2qm74	4826	41	)	)	-RRB-
cord-015021-pol2qm74	4826	42	.	.	.
cord-015021-pol2qm74	4827	1	Myeloperoxidase	myeloperoxidase	NN
cord-015021-pol2qm74	4827	2	activity	activity	NN
cord-015021-pol2qm74	4827	3	(	(	-LRB-
cord-015021-pol2qm74	4827	4	MPO	MPO	NNP
cord-015021-pol2qm74	4827	5	)	)	-RRB-
cord-015021-pol2qm74	4827	6	measured	measure	VBN
cord-015021-pol2qm74	4827	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4827	8	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4827	9	influx	influx	NN
cord-015021-pol2qm74	4827	10	.	.	.
cord-015021-pol2qm74	4828	1	Pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4828	2	endothelial	endothelial	JJ
cord-015021-pol2qm74	4828	3	permeability	permeability	NN
cord-015021-pol2qm74	4828	4	was	be	VBD
cord-015021-pol2qm74	4828	5	measured	measure	VBN
cord-015021-pol2qm74	4828	6	by	by	IN
cord-015021-pol2qm74	4828	7	wet	wet	JJ
cord-015021-pol2qm74	4828	8	to	to	IN
cord-015021-pol2qm74	4828	9	dry	dry	JJ
cord-015021-pol2qm74	4828	10	weight	weight	NN
cord-015021-pol2qm74	4828	11	ratio	ratio	NN
cord-015021-pol2qm74	4828	12	(	(	-LRB-
cord-015021-pol2qm74	4828	13	W	w	NN
cord-015021-pol2qm74	4828	14	/	/	SYM
cord-015021-pol2qm74	4828	15	D	D	NNP
cord-015021-pol2qm74	4828	16	)	)	-RRB-
cord-015021-pol2qm74	4828	17	,	,	,
cord-015021-pol2qm74	4828	18	broncboalveolar	broncboalveolar	NNP
cord-015021-pol2qm74	4828	19	lavage	lavage	NNP
cord-015021-pol2qm74	4828	20	protein	protein	NN
cord-015021-pol2qm74	4828	21	(	(	-LRB-
cord-015021-pol2qm74	4828	22	BAL	BAL	NNP
cord-015021-pol2qm74	4828	23	)	)	-RRB-
cord-015021-pol2qm74	4828	24	and	and	CC
cord-015021-pol2qm74	4828	25	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4828	26	counts	count	NNS
cord-015021-pol2qm74	4828	27	(	(	-LRB-
cord-015021-pol2qm74	4828	28	BAL	BAL	NNP
cord-015021-pol2qm74	4828	29	pmn	pmn	NN
cord-015021-pol2qm74	4828	30	)	)	-RRB-
cord-015021-pol2qm74	4828	31	.	.	.
cord-015021-pol2qm74	4829	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	4829	2	superoxide	superoxide	NN
cord-015021-pol2qm74	4829	3	release	release	NN
cord-015021-pol2qm74	4829	4	(	(	-LRB-
cord-015021-pol2qm74	4829	5	mean	mean	VB
cord-015021-pol2qm74	4829	6	channel	channel	NN
cord-015021-pol2qm74	4829	7	fluorescence	fluorescence	NN
cord-015021-pol2qm74	4829	8	MCF	MCF	NNP
cord-015021-pol2qm74	4829	9	)	)	-RRB-
cord-015021-pol2qm74	4829	10	was	be	VBD
cord-015021-pol2qm74	4829	11	measured	measure	VBN
cord-015021-pol2qm74	4829	12	by	by	IN
cord-015021-pol2qm74	4829	13	flow	flow	NN
cord-015021-pol2qm74	4829	14	cytometry	cytometry	NN
cord-015021-pol2qm74	4829	15	in	in	IN
cord-015021-pol2qm74	4829	16	a	a	DT
cord-015021-pol2qm74	4829	17	further	further	JJ
cord-015021-pol2qm74	4829	18	IR	IR	NNP
cord-015021-pol2qm74	4829	19	v	v	IN
cord-015021-pol2qm74	4829	20	GTN	GTN	NNP
cord-015021-pol2qm74	4829	21	experiment	experiment	NN
cord-015021-pol2qm74	4829	22	(	(	-LRB-
cord-015021-pol2qm74	4829	23	N=6	N=6	NNP
cord-015021-pol2qm74	4829	24	per	per	IN
cord-015021-pol2qm74	4829	25	group	group	NN
cord-015021-pol2qm74	4829	26	)	)	-RRB-
cord-015021-pol2qm74	4829	27	.	.	.
cord-015021-pol2qm74	4830	1	Control	control	NN
cord-015021-pol2qm74	4830	2	573_+t02	573_+t02	CD
cord-015021-pol2qm74	4830	3	"	"	''
cord-015021-pol2qm74	4831	1	*	*	NFP
cord-015021-pol2qm74	4831	2	992_+125	992_+125	CD
cord-015021-pol2qm74	4831	3	579_+54	579_+54	XX
cord-015021-pol2qm74	4832	1	*	*	NFP
cord-015021-pol2qm74	4832	2	*	*	NFP
cord-015021-pol2qm74	4832	3	BAL	BAL	NNP
cord-015021-pol2qm74	4832	4	pmn	pmn	NN
cord-015021-pol2qm74	4832	5	/	/	SYM
cord-015021-pol2qm74	4832	6	mm	mm	NN
cord-015021-pol2qm74	4833	1	3	3	CD
cord-015021-pol2qm74	4833	2	36l+-126	36l+-126	CD
cord-015021-pol2qm74	4833	3	3"219	3"219	NNS
cord-015021-pol2qm74	4833	4	+	+	CD
cord-015021-pol2qm74	4833	5	1087	1087	CD
cord-015021-pol2qm74	4833	6	#	#	$
cord-015021-pol2qm74	4833	7	820_~221	820_~221	CD
cord-015021-pol2qm74	4833	8	*	*	NFP
cord-015021-pol2qm74	4833	9	p<0.05	p<0.05	NN
cord-015021-pol2qm74	4833	10	,	,	,
cord-015021-pol2qm74	4833	11	#	#	NN
cord-015021-pol2qm74	4833	12	p<0.02	p<0.02	NN
cord-015021-pol2qm74	4833	13	v	v	IN
cord-015021-pol2qm74	4833	14	Control	Control	NNP
cord-015021-pol2qm74	4833	15	/	/	SYM
cord-015021-pol2qm74	4833	16	GTN;**p<0.01	GTN;**p<0.01	NNP
cord-015021-pol2qm74	4833	17	v	v	NNP
cord-015021-pol2qm74	4833	18	IR	IR	NNP
cord-015021-pol2qm74	4833	19	.	.	.
cord-015021-pol2qm74	4834	1	Students	student	NNS
cord-015021-pol2qm74	4834	2	t	t	NN
cord-015021-pol2qm74	4834	3	test	test	NN
cord-015021-pol2qm74	4835	1	The	the	DT
cord-015021-pol2qm74	4835	2	significant	significant	JJ
cord-015021-pol2qm74	4835	3	increase	increase	NN
cord-015021-pol2qm74	4835	4	in	in	IN
cord-015021-pol2qm74	4835	5	MPO	MPO	NNP
cord-015021-pol2qm74	4835	6	activity	activity	NN
cord-015021-pol2qm74	4835	7	produced	produce	VBN
cord-015021-pol2qm74	4835	8	by	by	IN
cord-015021-pol2qm74	4835	9	IR	IR	NNP
cord-015021-pol2qm74	4835	10	was	be	VBD
cord-015021-pol2qm74	4835	11	attenuated	attenuate	VBN
cord-015021-pol2qm74	4835	12	by	by	IN
cord-015021-pol2qm74	4835	13	GTN	GTN	NNP
cord-015021-pol2qm74	4835	14	.	.	.
cord-015021-pol2qm74	4836	1	The	the	DT
cord-015021-pol2qm74	4836	2	increase	increase	NN
cord-015021-pol2qm74	4836	3	in	in	IN
cord-015021-pol2qm74	4836	4	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4836	5	microvascular	microvascular	JJ
cord-015021-pol2qm74	4836	6	leakage	leakage	NN
cord-015021-pol2qm74	4836	7	after	after	IN
cord-015021-pol2qm74	4836	8	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4836	9	was	be	VBD
cord-015021-pol2qm74	4836	10	also	also	RB
cord-015021-pol2qm74	4836	11	prevented	prevent	VBN
cord-015021-pol2qm74	4836	12	by	by	IN
cord-015021-pol2qm74	4836	13	GTN	GTN	NNP
cord-015021-pol2qm74	4836	14	.	.	.
cord-015021-pol2qm74	4837	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	4837	2	superoxide	superoxide	NN
cord-015021-pol2qm74	4837	3	release	release	NN
cord-015021-pol2qm74	4837	4	increased	increase	VBD
cord-015021-pol2qm74	4837	5	significantly	significantly	RB
cord-015021-pol2qm74	4837	6	from	from	IN
cord-015021-pol2qm74	4837	7	9.4	9.4	CD
cord-015021-pol2qm74	4837	8	+	+	CD
cord-015021-pol2qm74	4837	9	0.76	0.76	CD
cord-015021-pol2qm74	4837	10	to	to	IN
cord-015021-pol2qm74	4837	11	13.9_+1.92	13.9_+1.92	CD
cord-015021-pol2qm74	4837	12	MCF	MCF	NNP
cord-015021-pol2qm74	4837	13	after	after	IN
cord-015021-pol2qm74	4837	14	40	40	CD
cord-015021-pol2qm74	4837	15	minutes	minute	NNS
cord-015021-pol2qm74	4837	16	repeffusion	repeffusion	NN
cord-015021-pol2qm74	4837	17	(	(	-LRB-
cord-015021-pol2qm74	4837	18	p<.01	p<.01	NNP
cord-015021-pol2qm74	4837	19	)	)	-RRB-
cord-015021-pol2qm74	4837	20	.	.	.
cord-015021-pol2qm74	4838	1	This	this	DT
cord-015021-pol2qm74	4838	2	increase	increase	NN
cord-015021-pol2qm74	4838	3	in	in	IN
cord-015021-pol2qm74	4838	4	superoxide	superoxide	NN
cord-015021-pol2qm74	4838	5	was	be	VBD
cord-015021-pol2qm74	4838	6	prevented	prevent	VBN
cord-015021-pol2qm74	4838	7	in	in	IN
cord-015021-pol2qm74	4838	8	the	the	DT
cord-015021-pol2qm74	4838	9	GTN	GTN	NNP
cord-015021-pol2qm74	4838	10	treated	treat	VBN
cord-015021-pol2qm74	4838	11	group	group	NN
cord-015021-pol2qm74	4838	12	.	.	.
cord-015021-pol2qm74	4839	1	These	these	DT
cord-015021-pol2qm74	4839	2	results	result	NNS
cord-015021-pol2qm74	4839	3	indicate	indicate	VBP
cord-015021-pol2qm74	4839	4	that	that	IN
cord-015021-pol2qm74	4839	5	GTN	GTN	NNP
cord-015021-pol2qm74	4839	6	inhibits	inhibit	VBZ
cord-015021-pol2qm74	4839	7	neutropbil	neutropbil	NN
cord-015021-pol2qm74	4839	8	superoxide	superoxide	NN
cord-015021-pol2qm74	4839	9	release	release	NN
cord-015021-pol2qm74	4839	10	during	during	IN
cord-015021-pol2qm74	4839	11	limb	limb	NN
cord-015021-pol2qm74	4839	12	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4839	13	,	,	,
cord-015021-pol2qm74	4839	14	thus	thus	RB
cord-015021-pol2qm74	4839	15	preventing	prevent	VBG
cord-015021-pol2qm74	4839	16	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4839	17	vascular	vascular	JJ
cord-015021-pol2qm74	4839	18	leakage	leakage	NN
cord-015021-pol2qm74	4839	19	and	and	CC
cord-015021-pol2qm74	4839	20	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4839	21	infiltration	infiltration	NN
cord-015021-pol2qm74	4839	22	.	.	.
cord-015021-pol2qm74	4840	1	These	these	DT
cord-015021-pol2qm74	4840	2	data	datum	NNS
cord-015021-pol2qm74	4840	3	suggest	suggest	VBP
cord-015021-pol2qm74	4840	4	that	that	IN
cord-015021-pol2qm74	4840	5	the	the	DT
cord-015021-pol2qm74	4840	6	beneficial	beneficial	JJ
cord-015021-pol2qm74	4840	7	effects	effect	NNS
cord-015021-pol2qm74	4840	8	of	of	IN
cord-015021-pol2qm74	4840	9	GTN	GTN	NNP
cord-015021-pol2qm74	4840	10	in	in	IN
cord-015021-pol2qm74	4840	11	aortic	aortic	JJ
cord-015021-pol2qm74	4840	12	surgery	surgery	NN
cord-015021-pol2qm74	4840	13	may	may	MD
cord-015021-pol2qm74	4840	14	be	be	VB
cord-015021-pol2qm74	4840	15	due	due	JJ
cord-015021-pol2qm74	4840	16	in	in	IN
cord-015021-pol2qm74	4840	17	part	part	NN
cord-015021-pol2qm74	4840	18	to	to	IN
cord-015021-pol2qm74	4840	19	a	a	DT
cord-015021-pol2qm74	4840	20	protective	protective	JJ
cord-015021-pol2qm74	4840	21	effect	effect	NN
cord-015021-pol2qm74	4840	22	onpulmonary	onpulmonary	JJ
cord-015021-pol2qm74	4840	23	microvasculature	microvasculature	NN
cord-015021-pol2qm74	4840	24	.	.	.
cord-015021-pol2qm74	4841	1	Department	Department	NNP
cord-015021-pol2qm74	4841	2	of	of	IN
cord-015021-pol2qm74	4841	3	Surgery	Surgery	NNP
cord-015021-pol2qm74	4841	4	,	,	,
cord-015021-pol2qm74	4841	5	Beaumont	Beaumont	NNP
cord-015021-pol2qm74	4841	6	Hospital	Hospital	NNP
cord-015021-pol2qm74	4841	7	,	,	,
cord-015021-pol2qm74	4841	8	Dublin	Dublin	NNP
cord-015021-pol2qm74	4841	9	9	9	CD
cord-015021-pol2qm74	4841	10	,	,	,
cord-015021-pol2qm74	4841	11	Ireland	Ireland	NNP
cord-015021-pol2qm74	4841	12	.	.	.
cord-015021-pol2qm74	4842	1	LIPTON	LIPTON	NNP
cord-015021-pol2qm74	4842	2	Adult	Adult	NNP
cord-015021-pol2qm74	4842	3	respiratory	respiratory	JJ
cord-015021-pol2qm74	4842	4	distress	distress	NN
cord-015021-pol2qm74	4842	5	syndrome	syndrome	NN
cord-015021-pol2qm74	4842	6	(	(	-LRB-
cord-015021-pol2qm74	4842	7	ARDS	ARDS	NNP
cord-015021-pol2qm74	4842	8	)	)	-RRB-
cord-015021-pol2qm74	4842	9	is	be	VBZ
cord-015021-pol2qm74	4842	10	marked	mark	VBN
cord-015021-pol2qm74	4842	11	by	by	IN
cord-015021-pol2qm74	4842	12	increased	increase	VBN
cord-015021-pol2qm74	4842	13	vascular	vascular	JJ
cord-015021-pol2qm74	4842	14	permeability	permeability	NN
cord-015021-pol2qm74	4842	15	of	of	IN
cord-015021-pol2qm74	4842	16	the	the	DT
cord-015021-pol2qm74	4842	17	lung	lung	NN
cord-015021-pol2qm74	4842	18	to	to	IN
cord-015021-pol2qm74	4842	19	white	white	NNP
cord-015021-pol2qm74	4842	20	blood	blood	NN
cord-015021-pol2qm74	4842	21	ceils	ceil	NNS
cord-015021-pol2qm74	4842	22	(	(	-LRB-
cord-015021-pol2qm74	4842	23	WBC	WBC	NNP
cord-015021-pol2qm74	4842	24	)	)	-RRB-
cord-015021-pol2qm74	4842	25	.	.	.
cord-015021-pol2qm74	4843	1	Indeed	indeed	RB
cord-015021-pol2qm74	4843	2	,	,	,
cord-015021-pol2qm74	4843	3	influx	influx	NN
cord-015021-pol2qm74	4843	4	of	of	IN
cord-015021-pol2qm74	4843	5	WBC	WBC	NNP
cord-015021-pol2qm74	4843	6	into	into	IN
cord-015021-pol2qm74	4843	7	the	the	DT
cord-015021-pol2qm74	4843	8	lung	lung	NN
cord-015021-pol2qm74	4843	9	is	be	VBZ
cord-015021-pol2qm74	4843	10	believed	believe	VBN
cord-015021-pol2qm74	4843	11	to	to	TO
cord-015021-pol2qm74	4843	12	be	be	VB
cord-015021-pol2qm74	4843	13	the	the	DT
cord-015021-pol2qm74	4843	14	central	central	JJ
cord-015021-pol2qm74	4843	15	mechanism	mechanism	NN
cord-015021-pol2qm74	4843	16	in	in	IN
cord-015021-pol2qm74	4843	17	acute	acute	JJ
cord-015021-pol2qm74	4843	18	lung	lung	NN
cord-015021-pol2qm74	4843	19	injury	injury	NN
cord-015021-pol2qm74	4843	20	of	of	IN
cord-015021-pol2qm74	4843	21	ARDS	ARDS	NNP
cord-015021-pol2qm74	4843	22	.	.	.
cord-015021-pol2qm74	4844	1	Evidence	evidence	NN
cord-015021-pol2qm74	4844	2	is	be	VBZ
cord-015021-pol2qm74	4844	3	developing	develop	VBG
cord-015021-pol2qm74	4844	4	that	that	IN
cord-015021-pol2qm74	4844	5	the	the	DT
cord-015021-pol2qm74	4844	6	neuropeptide	neuropeptide	NN
cord-015021-pol2qm74	4844	7	c~-melanocyte	c~-melanocyte	FW
cord-015021-pol2qm74	4844	8	stimulating	stimulate	VBG
cord-015021-pol2qm74	4844	9	hormone	hormone	NN
cord-015021-pol2qm74	4844	10	(	(	-LRB-
cord-015021-pol2qm74	4844	11	c~-MSH	c~-MSH	NNP
cord-015021-pol2qm74	4844	12	)	)	-RRB-
cord-015021-pol2qm74	4844	13	,	,	,
cord-015021-pol2qm74	4844	14	a	a	DT
cord-015021-pol2qm74	4844	15	proopiomelanocortin	proopiomelanocortin	NN
cord-015021-pol2qm74	4844	16	derivative	derivative	NN
cord-015021-pol2qm74	4844	17	,	,	,
cord-015021-pol2qm74	4844	18	inhibits	inhibit	VBZ
cord-015021-pol2qm74	4844	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4844	20	reactions	reaction	NNS
cord-015021-pol2qm74	4844	21	in	in	IN
cord-015021-pol2qm74	4844	22	animaI	animaI	NNP
cord-015021-pol2qm74	4844	23	models	model	NNS
cord-015021-pol2qm74	4844	24	of	of	IN
cord-015021-pol2qm74	4844	25	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4844	26	responses	response	NNS
cord-015021-pol2qm74	4844	27	in	in	IN
cord-015021-pol2qm74	4844	28	humans	human	NNS
cord-015021-pol2qm74	4844	29	.	.	.
cord-015021-pol2qm74	4845	1	To	to	TO
cord-015021-pol2qm74	4845	2	test	test	VB
cord-015021-pol2qm74	4845	3	the	the	DT
cord-015021-pol2qm74	4845	4	influence	influence	NN
cord-015021-pol2qm74	4845	5	of	of	IN
cord-015021-pol2qm74	4845	6	a	a	DT
cord-015021-pol2qm74	4845	7	-	-	:
cord-015021-pol2qm74	4845	8	MSH	MSH	NNP
cord-015021-pol2qm74	4845	9	on	on	IN
cord-015021-pol2qm74	4845	10	experimental	experimental	JJ
cord-015021-pol2qm74	4845	11	ARDS	ARDS	NNP
cord-015021-pol2qm74	4845	12	,	,	,
cord-015021-pol2qm74	4845	13	the	the	DT
cord-015021-pol2qm74	4845	14	peptide	peptide	NN
cord-015021-pol2qm74	4845	15	was	be	VBD
cord-015021-pol2qm74	4845	16	administered	administer	VBN
cord-015021-pol2qm74	4845	17	to	to	IN
cord-015021-pol2qm74	4845	18	rats	rat	NNS
cord-015021-pol2qm74	4845	19	after	after	IN
cord-015021-pol2qm74	4845	20	intratraeheal	intratraeheal	JJ
cord-015021-pol2qm74	4845	21	infusion	infusion	NN
cord-015021-pol2qm74	4845	22	of	of	IN
cord-015021-pol2qm74	4845	23	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4845	24	(	(	-LRB-
cord-015021-pol2qm74	4845	25	S.	S.	NNP
cord-015021-pol2qm74	4845	26	typhosa	typhosa	NNP
cord-015021-pol2qm74	4845	27	,	,	,
cord-015021-pol2qm74	4845	28	500	500	CD
cord-015021-pol2qm74	4845	29	#	#	$
cord-015021-pol2qm74	4845	30	g	g	NN
cord-015021-pol2qm74	4845	31	in	in	IN
cord-015021-pol2qm74	4845	32	0.25	0.25	CD
cord-015021-pol2qm74	4845	33	ml	ml	NN
cord-015021-pol2qm74	4845	34	saline	saline	NN
cord-015021-pol2qm74	4845	35	)	)	-RRB-
cord-015021-pol2qm74	4845	36	.	.	.
cord-015021-pol2qm74	4846	1	Three	three	CD
cord-015021-pol2qm74	4846	2	groups	group	NNS
cord-015021-pol2qm74	4846	3	(	(	-LRB-
cord-015021-pol2qm74	4846	4	n=10	n=10	``
cord-015021-pol2qm74	4846	5	each	each	DT
cord-015021-pol2qm74	4846	6	)	)	-RRB-
cord-015021-pol2qm74	4846	7	received	receive	VBD
cord-015021-pol2qm74	4846	8	:	:	:
cord-015021-pol2qm74	4846	9	intratracheai	intratracheai	NNP
cord-015021-pol2qm74	4846	10	infusion	infusion	NN
cord-015021-pol2qm74	4846	11	of	of	IN
cord-015021-pol2qm74	4846	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4846	13	plus	plus	CC
cord-015021-pol2qm74	4846	14	ip	ip	NN
cord-015021-pol2qm74	4846	15	injections	injection	NNS
cord-015021-pol2qm74	4846	16	of	of	IN
cord-015021-pol2qm74	4846	17	o~-MSH	o~-MSH	NNP
cord-015021-pol2qm74	4847	1	(	(	-LRB-
cord-015021-pol2qm74	4847	2	100	100	CD
cord-015021-pol2qm74	4848	1	~tg	~tg	NNP
cord-015021-pol2qm74	4849	1	in	in	IN
cord-015021-pol2qm74	4849	2	0.2	0.2	CD
cord-015021-pol2qm74	4849	3	ml	ml	NN
cord-015021-pol2qm74	4849	4	saline	saline	NN
cord-015021-pol2qm74	4849	5	)	)	-RRB-
cord-015021-pol2qm74	4849	6	at	at	IN
cord-015021-pol2qm74	4849	7	0	0	CD
cord-015021-pol2qm74	4849	8	,	,	,
cord-015021-pol2qm74	4849	9	2	2	CD
cord-015021-pol2qm74	4849	10	,	,	,
cord-015021-pol2qm74	4849	11	and	and	CC
cord-015021-pol2qm74	4849	12	4	4	CD
cord-015021-pol2qm74	4849	13	hr	hr	NN
cord-015021-pol2qm74	4849	14	post	post	JJ
cord-015021-pol2qm74	4849	15	-	-	JJ
cord-015021-pol2qm74	4849	16	endotoxin	endotoxin	JJ
cord-015021-pol2qm74	4849	17	treatment	treatment	NN
cord-015021-pol2qm74	4849	18	;	;	:
cord-015021-pol2qm74	4849	19	intratracheal	intratracheal	NN
cord-015021-pol2qm74	4849	20	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4849	21	infusion	infusion	NN
cord-015021-pol2qm74	4849	22	plus	plus	CC
cord-015021-pol2qm74	4849	23	saline	saline	NN
cord-015021-pol2qm74	4849	24	injections	injection	NNS
cord-015021-pol2qm74	4849	25	;	;	:
cord-015021-pol2qm74	4849	26	control	control	NNP
cord-015021-pol2qm74	4849	27	intratracheal	intratracheal	NNP
cord-015021-pol2qm74	4849	28	saline	saline	NN
cord-015021-pol2qm74	4849	29	infusion	infusion	NN
cord-015021-pol2qm74	4849	30	plus	plus	IN
cord-015021-pol2qm74	4849	31	saline	saline	NN
cord-015021-pol2qm74	4849	32	injections	injection	NNS
cord-015021-pol2qm74	4849	33	.	.	.
cord-015021-pol2qm74	4850	1	The	the	DT
cord-015021-pol2qm74	4850	2	BAL	BAL	NNP
cord-015021-pol2qm74	4850	3	data	datum	NNS
cord-015021-pol2qm74	4850	4	showed	show	VBD
cord-015021-pol2qm74	4850	5	overall	overall	JJ
cord-015021-pol2qm74	4850	6	differences	difference	NNS
cord-015021-pol2qm74	4850	7	among	among	IN
cord-015021-pol2qm74	4850	8	groups	group	NNS
cord-015021-pol2qm74	4850	9	(	(	-LRB-
cord-015021-pol2qm74	4850	10	F2,29=6.2	F2,29=6.2	NNP
cord-015021-pol2qm74	4850	11	,	,	,
cord-015021-pol2qm74	4850	12	p<.003	p<.003	NNP
cord-015021-pol2qm74	4850	13	)	)	-RRB-
cord-015021-pol2qm74	4850	14	,	,	,
cord-015021-pol2qm74	4850	15	o~-MSH	o~-MSH	NNP
cord-015021-pol2qm74	4850	16	treatment	treatment	NN
cord-015021-pol2qm74	4850	17	inhibited	inhibit	VBN
cord-015021-pol2qm74	4850	18	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4850	19	-	-	HYPH
cord-015021-pol2qm74	4850	20	induced	induce	VBN
cord-015021-pol2qm74	4850	21	WBC	WBC	NNP
cord-015021-pol2qm74	4850	22	migration	migration	NN
cord-015021-pol2qm74	4850	23	into	into	IN
cord-015021-pol2qm74	4850	24	the	the	DT
cord-015021-pol2qm74	4850	25	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4850	26	tree	tree	NN
cord-015021-pol2qm74	4850	27	(	(	-LRB-
cord-015021-pol2qm74	4850	28	p<.05	p<.05	NNP
cord-015021-pol2qm74	4850	29	)	)	-RRB-
cord-015021-pol2qm74	4850	30	.	.	.
cord-015021-pol2qm74	4851	1	Circulating	circulate	VBG
cord-015021-pol2qm74	4851	2	WBC	WBC	NNP
cord-015021-pol2qm74	4851	3	counts	count	NNS
cord-015021-pol2qm74	4851	4	were	be	VBD
cord-015021-pol2qm74	4851	5	markedly	markedly	RB
cord-015021-pol2qm74	4851	6	lower	low	JJR
cord-015021-pol2qm74	4851	7	in	in	IN
cord-015021-pol2qm74	4851	8	both	both	DT
cord-015021-pol2qm74	4851	9	groups	group	NNS
cord-015021-pol2qm74	4851	10	given	give	VBN
cord-015021-pol2qm74	4851	11	endoroxin	endoroxin	NNP
cord-015021-pol2qm74	4851	12	than	than	IN
cord-015021-pol2qm74	4851	13	in	in	IN
cord-015021-pol2qm74	4851	14	the	the	DT
cord-015021-pol2qm74	4851	15	control	control	NN
cord-015021-pol2qm74	4851	16	group	group	NN
cord-015021-pol2qm74	4851	17	(	(	-LRB-
cord-015021-pol2qm74	4851	18	p<.01	p<.01	NNP
cord-015021-pol2qm74	4851	19	)	)	-RRB-
cord-015021-pol2qm74	4851	20	,	,	,
cord-015021-pol2qm74	4851	21	but	but	CC
cord-015021-pol2qm74	4851	22	there	there	EX
cord-015021-pol2qm74	4851	23	was	be	VBD
cord-015021-pol2qm74	4851	24	no	no	DT
cord-015021-pol2qm74	4851	25	difference	difference	NN
cord-015021-pol2qm74	4851	26	in	in	IN
cord-015021-pol2qm74	4851	27	WBC	WBC	NNP
cord-015021-pol2qm74	4851	28	count	count	NN
cord-015021-pol2qm74	4851	29	between	between	IN
cord-015021-pol2qm74	4851	30	these	these	DT
cord-015021-pol2qm74	4851	31	two	two	CD
cord-015021-pol2qm74	4851	32	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4851	33	-	-	HYPH
cord-015021-pol2qm74	4851	34	treated	treat	VBN
cord-015021-pol2qm74	4851	35	groups	group	NNS
cord-015021-pol2qm74	4851	36	.	.	.
cord-015021-pol2qm74	4852	1	The	the	DT
cord-015021-pol2qm74	4852	2	results	result	NNS
cord-015021-pol2qm74	4852	3	indicate	indicate	VBP
cord-015021-pol2qm74	4852	4	that	that	IN
cord-015021-pol2qm74	4852	5	c~-MSH	c~-msh	NN
cord-015021-pol2qm74	4852	6	can	can	MD
cord-015021-pol2qm74	4852	7	reduce	reduce	VB
cord-015021-pol2qm74	4852	8	WBC	WBC	NNP
cord-015021-pol2qm74	4852	9	migration	migration	NN
cord-015021-pol2qm74	4852	10	in	in	IN
cord-015021-pol2qm74	4852	11	experimental	experimental	JJ
cord-015021-pol2qm74	4852	12	lung	lung	NN
cord-015021-pol2qm74	4852	13	injury	injury	NN
cord-015021-pol2qm74	4852	14	.	.	.
cord-015021-pol2qm74	4853	1	In	in	IN
cord-015021-pol2qm74	4853	2	further	further	JJ
cord-015021-pol2qm74	4853	3	experiments	experiment	NNS
cord-015021-pol2qm74	4853	4	we	-PRON-	PRP
cord-015021-pol2qm74	4853	5	tested	test	VBD
cord-015021-pol2qm74	4853	6	the	the	DT
cord-015021-pol2qm74	4853	7	hypothesis	hypothesis	NN
cord-015021-pol2qm74	4853	8	that	that	IN
cord-015021-pol2qm74	4853	9	c~-MSH	c~-MSH	NNP
cord-015021-pol2qm74	4853	10	,	,	,
cord-015021-pol2qm74	4853	11	administered	administer	VBN
cord-015021-pol2qm74	4853	12	alone	alone	RB
cord-015021-pol2qm74	4853	13	or	or	CC
cord-015021-pol2qm74	4853	14	in	in	IN
cord-015021-pol2qm74	4853	15	combination	combination	NN
cord-015021-pol2qm74	4853	16	with	with	IN
cord-015021-pol2qm74	4853	17	an	an	DT
cord-015021-pol2qm74	4853	18	inhibitor	inhibitor	NN
cord-015021-pol2qm74	4853	19	of	of	IN
cord-015021-pol2qm74	4853	20	gram	gram	JJ
cord-015021-pol2qm74	4853	21	-	-	HYPH
cord-015021-pol2qm74	4853	22	negative	negative	JJ
cord-015021-pol2qm74	4853	23	bacterial	bacterial	JJ
cord-015021-pol2qm74	4853	24	growth	growth	NN
cord-015021-pol2qm74	4853	25	,	,	,
cord-015021-pol2qm74	4853	26	increases	increase	VBZ
cord-015021-pol2qm74	4853	27	survival	survival	NN
cord-015021-pol2qm74	4853	28	in	in	IN
cord-015021-pol2qm74	4853	29	a	a	DT
cord-015021-pol2qm74	4853	30	model	model	NN
cord-015021-pol2qm74	4853	31	of	of	IN
cord-015021-pol2qm74	4853	32	peritonitis	peritonitis	NN
cord-015021-pol2qm74	4853	33	/	/	SYM
cord-015021-pol2qm74	4853	34	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4853	35	/	/	SYM
cord-015021-pol2qm74	4853	36	septie	septie	NN
cord-015021-pol2qm74	4853	37	shock	shock	NN
cord-015021-pol2qm74	4853	38	.	.	.
cord-015021-pol2qm74	4854	1	Cecal	Cecal	NNP
cord-015021-pol2qm74	4854	2	ligation	ligation	NN
cord-015021-pol2qm74	4854	3	and	and	CC
cord-015021-pol2qm74	4854	4	puncture	puncture	NN
cord-015021-pol2qm74	4854	5	were	be	VBD
cord-015021-pol2qm74	4854	6	performed	perform	VBN
cord-015021-pol2qm74	4854	7	under	under	IN
cord-015021-pol2qm74	4854	8	sodium	sodium	NN
cord-015021-pol2qm74	4854	9	pemobarbital	pemobarbital	NNP
cord-015021-pol2qm74	4854	10	anesthesia	anesthesia	NNP
cord-015021-pol2qm74	4854	11	(	(	-LRB-
cord-015021-pol2qm74	4854	12	75	75	CD
cord-015021-pol2qm74	4854	13	mg	mg	NNP
cord-015021-pol2qm74	4854	14	/	/	SYM
cord-015021-pol2qm74	4854	15	kg	kg	NNP
cord-015021-pol2qm74	4854	16	,	,	,
cord-015021-pol2qm74	4854	17	i.p	i.p	NNP
cord-015021-pol2qm74	4854	18	.	.	NNP
cord-015021-pol2qm74	4854	19	)	)	-RRB-
cord-015021-pol2qm74	4854	20	in	in	IN
cord-015021-pol2qm74	4854	21	female	female	JJ
cord-015021-pol2qm74	4854	22	BALB	BALB	NNP
cord-015021-pol2qm74	4854	23	/	/	SYM
cord-015021-pol2qm74	4854	24	c	c	NN
cord-015021-pol2qm74	4854	25	mice	mouse	NNS
cord-015021-pol2qm74	4854	26	(	(	-LRB-
cord-015021-pol2qm74	4854	27	16	16	CD
cord-015021-pol2qm74	4854	28	-	-	SYM
cord-015021-pol2qm74	4854	29	20	20	CD
cord-015021-pol2qm74	4854	30	g	g	NN
cord-015021-pol2qm74	4854	31	)	)	-RRB-
cord-015021-pol2qm74	4854	32	that	that	WDT
cord-015021-pol2qm74	4854	33	were	be	VBD
cord-015021-pol2qm74	4854	34	then	then	RB
cord-015021-pol2qm74	4854	35	randomly	randomly	RB
cord-015021-pol2qm74	4854	36	assigned	assign	VBN
cord-015021-pol2qm74	4854	37	(	(	-LRB-
cord-015021-pol2qm74	4854	38	15	15	CD
cord-015021-pol2qm74	4854	39	-	-	SYM
cord-015021-pol2qm74	4854	40	17	17	CD
cord-015021-pol2qm74	4854	41	mice	mouse	NNS
cord-015021-pol2qm74	4854	42	per	per	IN
cord-015021-pol2qm74	4854	43	group	group	NN
cord-015021-pol2qm74	4854	44	)	)	-RRB-
cord-015021-pol2qm74	4854	45	to	to	TO
cord-015021-pol2qm74	4854	46	receive	receive	VB
cord-015021-pol2qm74	4854	47	at	at	IN
cord-015021-pol2qm74	4854	48	time	time	NN
cord-015021-pol2qm74	4854	49	0	0	CD
cord-015021-pol2qm74	4854	50	and	and	CC
cord-015021-pol2qm74	4854	51	3	3	CD
cord-015021-pol2qm74	4854	52	hr	hr	NN
cord-015021-pol2qm74	4854	53	later	later	RB
cord-015021-pol2qm74	4854	54	:	:	:
cord-015021-pol2qm74	4854	55	control	control	NNP
cord-015021-pol2qm74	4854	56	saline	saline	NNP
cord-015021-pol2qm74	4854	57	thjectioas	thjectioas	NNP
cord-015021-pol2qm74	4854	58	(	(	-LRB-
cord-015021-pol2qm74	4854	59	i.p	i.p	NNP
cord-015021-pol2qm74	4854	60	.	.	NNP
cord-015021-pol2qm74	4854	61	)	)	-RRB-
cord-015021-pol2qm74	4854	62	,	,	,
cord-015021-pol2qm74	4854	63	injections	injection	NNS
cord-015021-pol2qm74	4854	64	of	of	IN
cord-015021-pol2qm74	4854	65	~-MSH	~-msh	CD
cord-015021-pol2qm74	4855	1	(	(	-LRB-
cord-015021-pol2qm74	4855	2	100	100	CD
cord-015021-pol2qm74	4855	3	~tg	~tg	NNS
cord-015021-pol2qm74	4855	4	)	)	-RRB-
cord-015021-pol2qm74	4855	5	,	,	,
cord-015021-pol2qm74	4855	6	gentamicin	gentamicin	NN
cord-015021-pol2qm74	4855	7	sulfate	sulfate	NN
cord-015021-pol2qm74	4855	8	(	(	-LRB-
cord-015021-pol2qm74	4855	9	I0	I0	NNP
cord-015021-pol2qm74	4855	10	mg	mg	NNP
cord-015021-pol2qm74	4855	11	/	/	SYM
cord-015021-pol2qm74	4855	12	kg	kg	NNP
cord-015021-pol2qm74	4855	13	)	)	-RRB-
cord-015021-pol2qm74	4855	14	,	,	,
cord-015021-pol2qm74	4855	15	or	or	CC
cord-015021-pol2qm74	4855	16	both	both	DT
cord-015021-pol2qm74	4855	17	~-MSH	~-msh	CD
cord-015021-pol2qm74	4855	18	and	and	CC
cord-015021-pol2qm74	4855	19	gentamicin	gentamicin	NN
cord-015021-pol2qm74	4855	20	.	.	.
cord-015021-pol2qm74	4856	1	One	one	CD
cord-015021-pol2qm74	4856	2	ml	ml	NN
cord-015021-pol2qm74	4856	3	of	of	IN
cord-015021-pol2qm74	4856	4	normal	normal	JJ
cord-015021-pol2qm74	4856	5	saline	saline	NN
cord-015021-pol2qm74	4856	6	was	be	VBD
cord-015021-pol2qm74	4856	7	given	give	VBN
cord-015021-pol2qm74	4856	8	s.c	s.c	NNP
cord-015021-pol2qm74	4856	9	.	.	.
cord-015021-pol2qm74	4857	1	to	to	IN
cord-015021-pol2qm74	4857	2	each	each	DT
cord-015021-pol2qm74	4857	3	animal	animal	NN
cord-015021-pol2qm74	4857	4	for	for	IN
cord-015021-pol2qm74	4857	5	fluid	fluid	JJ
cord-015021-pol2qm74	4857	6	replacement	replacement	NN
cord-015021-pol2qm74	4857	7	.	.	.
cord-015021-pol2qm74	4858	1	Both	both	DT
cord-015021-pol2qm74	4858	2	Ix	Ix	NNP
cord-015021-pol2qm74	4858	3	-	-	HYPH
cord-015021-pol2qm74	4858	4	MSH	MSH	NNP
cord-015021-pol2qm74	4858	5	and	and	CC
cord-015021-pol2qm74	4858	6	gentamicin	gentamicin	NN
cord-015021-pol2qm74	4858	7	treatments	treatment	NNS
cord-015021-pol2qm74	4858	8	administered	administer	VBN
cord-015021-pol2qm74	4858	9	singly	singly	RB
cord-015021-pol2qm74	4858	10	improved	improve	VBN
cord-015021-pol2qm74	4858	11	survival	survival	NN
cord-015021-pol2qm74	4858	12	;	;	:
cord-015021-pol2qm74	4858	13	when	when	WRB
cord-015021-pol2qm74	4858	14	given	give	VBN
cord-015021-pol2qm74	4858	15	in	in	IN
cord-015021-pol2qm74	4858	16	combination	combination	NN
cord-015021-pol2qm74	4858	17	survival	survival	NN
cord-015021-pol2qm74	4858	18	was	be	VBD
cord-015021-pol2qm74	4858	19	even	even	RB
cord-015021-pol2qm74	4858	20	greater	great	JJR
cord-015021-pol2qm74	4858	21	These	these	DT
cord-015021-pol2qm74	4858	22	findings	finding	NNS
cord-015021-pol2qm74	4858	23	suggest	suggest	VBP
cord-015021-pol2qm74	4858	24	that	that	IN
cord-015021-pol2qm74	4858	25	the	the	DT
cord-015021-pol2qm74	4858	26	anticytokine	anticytokine	NNP
cord-015021-pol2qm74	4858	27	ot	ot	NN
cord-015021-pol2qm74	4858	28	-MSH	-msh	NN
cord-015021-pol2qm74	4858	29	molecule	molecule	NN
cord-015021-pol2qm74	4858	30	might	may	MD
cord-015021-pol2qm74	4858	31	be	be	VB
cord-015021-pol2qm74	4858	32	useful	useful	JJ
cord-015021-pol2qm74	4858	33	for	for	IN
cord-015021-pol2qm74	4858	34	treatment	treatment	NN
cord-015021-pol2qm74	4858	35	of	of	IN
cord-015021-pol2qm74	4858	36	systemic	systemic	JJ
cord-015021-pol2qm74	4858	37	inflammation	inflammation	NN
cord-015021-pol2qm74	4858	38	,	,	,
cord-015021-pol2qm74	4858	39	perhaps	perhaps	RB
cord-015021-pol2qm74	4858	40	particularly	particularly	RB
cord-015021-pol2qm74	4858	41	when	when	WRB
cord-015021-pol2qm74	4858	42	used	use	VBN
cord-015021-pol2qm74	4858	43	in	in	IN
cord-015021-pol2qm74	4858	44	combination	combination	NN
cord-015021-pol2qm74	4858	45	with	with	IN
cord-015021-pol2qm74	4858	46	agents	agent	NNS
cord-015021-pol2qm74	4858	47	that	that	WDT
cord-015021-pol2qm74	4858	48	inhibit	inhibit	VBP
cord-015021-pol2qm74	4858	49	bacterial	bacterial	JJ
cord-015021-pol2qm74	4858	50	growth	growth	NN
cord-015021-pol2qm74	4858	51	.	.	.
cord-015021-pol2qm74	4859	1	Previous	previous	JJ
cord-015021-pol2qm74	4859	2	studies	study	NNS
cord-015021-pol2qm74	4859	3	showed	show	VBD
cord-015021-pol2qm74	4859	4	a	a	DT
cord-015021-pol2qm74	4859	5	close	close	JJ
cord-015021-pol2qm74	4859	6	relationship	relationship	NN
cord-015021-pol2qm74	4859	7	between	between	IN
cord-015021-pol2qm74	4859	8	xanthine	xanthine	NN
cord-015021-pol2qm74	4859	9	oxidase	oxidase	NN
cord-015021-pol2qm74	4859	10	activation	activation	NN
cord-015021-pol2qm74	4859	11	,	,	,
cord-015021-pol2qm74	4859	12	membrane	membrane	NN
cord-015021-pol2qm74	4859	13	damage	damage	NN
cord-015021-pol2qm74	4859	14	and	and	CC
cord-015021-pol2qm74	4859	15	postischemic	postischemic	JJ
cord-015021-pol2qm74	4859	16	cardio	cardio	NN
cord-015021-pol2qm74	4859	17	-	-	HYPH
cord-015021-pol2qm74	4859	18	respiratory	respiratory	JJ
cord-015021-pol2qm74	4859	19	failure	failure	NN
cord-015021-pol2qm74	4859	20	following	follow	VBG
cord-015021-pol2qm74	4859	21	aortic	aortic	JJ
cord-015021-pol2qm74	4859	22	clamping	clamping	NN
cord-015021-pol2qm74	4859	23	and	and	CC
cord-015021-pol2qm74	4859	24	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4859	25	.	.	.
cord-015021-pol2qm74	4860	1	Aim	aim	VB
cord-015021-pol2qm74	4860	2	of	of	IN
cord-015021-pol2qm74	4860	3	the	the	DT
cord-015021-pol2qm74	4860	4	present	present	JJ
cord-015021-pol2qm74	4860	5	study	study	NN
cord-015021-pol2qm74	4860	6	was	be	VBD
cord-015021-pol2qm74	4860	7	to	to	TO
cord-015021-pol2qm74	4860	8	evaluate	evaluate	VB
cord-015021-pol2qm74	4860	9	alterations	alteration	NNS
cord-015021-pol2qm74	4860	10	of	of	IN
cord-015021-pol2qm74	4860	11	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	4860	12	leukocyte	leukocyte	NN
cord-015021-pol2qm74	4860	13	(	(	-LRB-
cord-015021-pol2qm74	4860	14	PMNL)-metabolism	PMNL)-metabolism	NNP
cord-015021-pol2qm74	4860	15	and	and	CC
cord-015021-pol2qm74	4860	16	signal	signal	NN
cord-015021-pol2qm74	4860	17	lransduction	lransduction	NN
cord-015021-pol2qm74	4860	18	systems	system	NNS
cord-015021-pol2qm74	4860	19	during	during	IN
cord-015021-pol2qm74	4860	20	ischemia	ischemia	NN
cord-015021-pol2qm74	4860	21	/	/	SYM
cord-015021-pol2qm74	4860	22	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4860	23	induced	induce	VBN
cord-015021-pol2qm74	4860	24	by	by	IN
cord-015021-pol2qm74	4860	25	aortic	aortic	JJ
cord-015021-pol2qm74	4860	26	clamping	clamping	NN
cord-015021-pol2qm74	4860	27	in	in	IN
cord-015021-pol2qm74	4860	28	man	man	NN
cord-015021-pol2qm74	4860	29	.	.	.
cord-015021-pol2qm74	4861	1	Methods	method	NNS
cord-015021-pol2qm74	4861	2	,	,	,
cord-015021-pol2qm74	4861	3	In	in	IN
cord-015021-pol2qm74	4861	4	14	14	CD
cord-015021-pol2qm74	4861	5	Patients	patient	NNS
cord-015021-pol2qm74	4861	6	(	(	-LRB-
cord-015021-pol2qm74	4861	7	3	3	CD
cord-015021-pol2qm74	4861	8	female	female	JJ
cord-015021-pol2qm74	4861	9	,	,	,
cord-015021-pol2qm74	4861	10	59	59	CD
cord-015021-pol2qm74	4861	11	+	+	SYM
cord-015021-pol2qm74	4861	12	4	4	CD
cord-015021-pol2qm74	4861	13	years	year	NNS
cord-015021-pol2qm74	4861	14	)	)	-RRB-
cord-015021-pol2qm74	4861	15	with	with	IN
cord-015021-pol2qm74	4861	16	elective	elective	JJ
cord-015021-pol2qm74	4861	17	reconstruction	reconstruction	NN
cord-015021-pol2qm74	4861	18	of	of	IN
cord-015021-pol2qm74	4861	19	infrarenal	infrarenal	JJ
cord-015021-pol2qm74	4861	20	aortic	aortic	JJ
cord-015021-pol2qm74	4861	21	anearysms	anearysm	NNS
cord-015021-pol2qm74	4861	22	,	,	,
cord-015021-pol2qm74	4861	23	arterial	arterial	JJ
cord-015021-pol2qm74	4861	24	(	(	-LRB-
cord-015021-pol2qm74	4861	25	a	a	DT
cord-015021-pol2qm74	4861	26	)	)	-RRB-
cord-015021-pol2qm74	4861	27	and	and	CC
cord-015021-pol2qm74	4861	28	venous	venous	JJ
cord-015021-pol2qm74	4861	29	(	(	-LRB-
cord-015021-pol2qm74	4861	30	v	v	NN
cord-015021-pol2qm74	4861	31	)	)	-RRB-
cord-015021-pol2qm74	4861	32	blood	blood	NN
cord-015021-pol2qm74	4861	33	samples	sample	NNS
cord-015021-pol2qm74	4861	34	were	be	VBD
cord-015021-pol2qm74	4861	35	obtained	obtain	VBN
cord-015021-pol2qm74	4861	36	before	before	IN
cord-015021-pol2qm74	4861	37	clamping	clamp	VBG
cord-015021-pol2qm74	4861	38	and	and	CC
cord-015021-pol2qm74	4861	39	declamping	declampe	VBG
cord-015021-pol2qm74	4861	40	,	,	,
cord-015021-pol2qm74	4861	41	and	and	CC
cord-015021-pol2qm74	4861	42	60	60	CD
cord-015021-pol2qm74	4861	43	min	min	NN
cord-015021-pol2qm74	4861	44	after	after	IN
cord-015021-pol2qm74	4861	45	declamping	declampe	VBG
cord-015021-pol2qm74	4861	46	.	.	.
cord-015021-pol2qm74	4862	1	Arterial	arterial	JJ
cord-015021-pol2qm74	4862	2	PLA	PLA	NNP
cord-015021-pol2qm74	4862	3	2	2	CD
cord-015021-pol2qm74	4862	4	concentrations	concentration	NNS
cord-015021-pol2qm74	4862	5	were	be	VBD
cord-015021-pol2qm74	4862	6	higher	high	JJR
cord-015021-pol2qm74	4862	7	than	than	IN
cord-015021-pol2qm74	4862	8	venous	venous	JJ
cord-015021-pol2qm74	4862	9	(	(	-LRB-
cord-015021-pol2qm74	4862	10	113	113	CD
cord-015021-pol2qm74	4862	11	+	+	SYM
cord-015021-pol2qm74	4862	12	32	32	CD
cord-015021-pol2qm74	4862	13	vs.	vs.	NN
cord-015021-pol2qm74	4862	14	71	71	CD
cord-015021-pol2qm74	4862	15	+	+	SYM
cord-015021-pol2qm74	4862	16	30	30	CD
cord-015021-pol2qm74	4862	17	)	)	-RRB-
cord-015021-pol2qm74	4862	18	.	.	.
cord-015021-pol2qm74	4863	1	While	while	IN
cord-015021-pol2qm74	4863	2	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	4863	3	basal	basal	NN
cord-015021-pol2qm74	4863	4	PMNL	PMNL	NNP
cord-015021-pol2qm74	4864	1	Ca	ca	NN
cord-015021-pol2qm74	4864	2	2	2	CD
cord-015021-pol2qm74	4864	3	+	+	CD
cord-015021-pol2qm74	4864	4	concenlxation	concenlxation	NN
cord-015021-pol2qm74	4864	5	was	be	VBD
cord-015021-pol2qm74	4864	6	not	not	RB
cord-015021-pol2qm74	4864	7	altered	alter	VBN
cord-015021-pol2qm74	4864	8	at	at	IN
cord-015021-pol2qm74	4864	9	the	the	DT
cord-015021-pol2qm74	4864	10	end	end	NN
cord-015021-pol2qm74	4864	11	of	of	IN
cord-015021-pol2qm74	4864	12	ischemia	ischemia	NN
cord-015021-pol2qm74	4864	13	(	(	-LRB-
cord-015021-pol2qm74	4864	14	v	v	NN
cord-015021-pol2qm74	4864	15	:	:	:
cord-015021-pol2qm74	4864	16	52.3	52.3	CD
cord-015021-pol2qm74	4864	17	+	+	SYM
cord-015021-pol2qm74	4864	18	8	8	CD
cord-015021-pol2qm74	4864	19	;	;	:
cord-015021-pol2qm74	4864	20	a	a	DT
cord-015021-pol2qm74	4864	21	:	:	:
cord-015021-pol2qm74	4864	22	42_+6	42_+6	CD
cord-015021-pol2qm74	4864	23	)	)	-RRB-
cord-015021-pol2qm74	4864	24	and	and	CC
cord-015021-pol2qm74	4864	25	during	during	IN
cord-015021-pol2qm74	4864	26	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4864	27	(	(	-LRB-
cord-015021-pol2qm74	4864	28	v	v	NN
cord-015021-pol2qm74	4864	29	:	:	:
cord-015021-pol2qm74	4864	30	60	60	CD
cord-015021-pol2qm74	4864	31	+	+	SYM
cord-015021-pol2qm74	4864	32	8	8	CD
cord-015021-pol2qm74	4864	33	;	;	:
cord-015021-pol2qm74	4864	34	a	a	DT
cord-015021-pol2qm74	4864	35	:	:	:
cord-015021-pol2qm74	4864	36	69	69	CD
cord-015021-pol2qm74	4864	37	+	+	SYM
cord-015021-pol2qm74	4864	38	12	12	CD
cord-015021-pol2qm74	4864	39	)	)	-RRB-
cord-015021-pol2qm74	4864	40	,	,	,
cord-015021-pol2qm74	4864	41	FMLP	FMLP	NNP
cord-015021-pol2qm74	4864	42	-	-	HYPH
cord-015021-pol2qm74	4864	43	stimulated	stimulate	VBN
cord-015021-pol2qm74	4864	44	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	4865	1	Ca	ca	NN
cord-015021-pol2qm74	4865	2	2	2	CD
cord-015021-pol2qm74	4865	3	+	+	CD
cord-015021-pol2qm74	4866	1	mobilization	mobilization	NN
cord-015021-pol2qm74	4866	2	showed	show	VBD
cord-015021-pol2qm74	4866	3	a	a	DT
cord-015021-pol2qm74	4866	4	significant	significant	JJ
cord-015021-pol2qm74	4866	5	arterial	arterial	JJ
cord-015021-pol2qm74	4866	6	increase	increase	NN
cord-015021-pol2qm74	4866	7	as	as	IN
cord-015021-pol2qm74	4866	8	compared	compare	VBN
cord-015021-pol2qm74	4866	9	to	to	IN
cord-015021-pol2qm74	4866	10	venous	venous	JJ
cord-015021-pol2qm74	4866	11	(	(	-LRB-
cord-015021-pol2qm74	4866	12	1652_+601	1652_+601	CD
cord-015021-pol2qm74	4866	13	vs.	vs.	IN
cord-015021-pol2qm74	4866	14	638	638	CD
cord-015021-pol2qm74	4866	15	+	+	SYM
cord-015021-pol2qm74	4866	16	85	85	CD
cord-015021-pol2qm74	4866	17	,	,	,
cord-015021-pol2qm74	4866	18	p	p	NN
cord-015021-pol2qm74	4866	19	<	<	XX
cord-015021-pol2qm74	4866	20	.05	.05	NFP
cord-015021-pol2qm74	4866	21	)	)	-RRB-
cord-015021-pol2qm74	4866	22	.	.	.
cord-015021-pol2qm74	4867	1	These	these	DT
cord-015021-pol2qm74	4867	2	presented	present	VBN
cord-015021-pol2qm74	4867	3	data	datum	NNS
cord-015021-pol2qm74	4867	4	indicate	indicate	VBP
cord-015021-pol2qm74	4867	5	that	that	IN
cord-015021-pol2qm74	4867	6	the	the	DT
cord-015021-pol2qm74	4867	7	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4867	8	syndrome	syndrome	NN
cord-015021-pol2qm74	4867	9	after	after	IN
cord-015021-pol2qm74	4867	10	infrarenal	infrarenal	JJ
cord-015021-pol2qm74	4867	11	aortic	aortic	NNP
cord-015021-pol2qm74	4867	12	clamping	clamping	NN
cord-015021-pol2qm74	4867	13	is	be	VBZ
cord-015021-pol2qm74	4867	14	characterized	characterize	VBN
cord-015021-pol2qm74	4867	15	by	by	IN
cord-015021-pol2qm74	4867	16	1	1	CD
cord-015021-pol2qm74	4867	17	)	)	-RRB-
cord-015021-pol2qm74	4867	18	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4867	19	membrane	membrane	NN
cord-015021-pol2qm74	4867	20	damage	damage	NN
cord-015021-pol2qm74	4867	21	possibly	possibly	RB
cord-015021-pol2qm74	4867	22	due	due	JJ
cord-015021-pol2qm74	4867	23	to	to	IN
cord-015021-pol2qm74	4867	24	PMNL	PMNL	NNP
cord-015021-pol2qm74	4867	25	-	-	HYPH
cord-015021-pol2qm74	4867	26	degranulation	degranulation	NN
cord-015021-pol2qm74	4867	27	,	,	,
cord-015021-pol2qm74	4867	28	2	2	CD
cord-015021-pol2qm74	4867	29	)	)	-RRB-
cord-015021-pol2qm74	4867	30	activation	activation	NN
cord-015021-pol2qm74	4867	31	of	of	IN
cord-015021-pol2qm74	4867	32	PMNL	PMNL	NNP
cord-015021-pol2qm74	4867	33	-	-	HYPH
cord-015021-pol2qm74	4867	34	superoxide	superoxide	NN
cord-015021-pol2qm74	4867	35	radical	radical	JJ
cord-015021-pol2qm74	4867	36	production	production	NN
cord-015021-pol2qm74	4867	37	with	with	IN
cord-015021-pol2qm74	4867	38	release	release	NN
cord-015021-pol2qm74	4867	39	of	of	IN
cord-015021-pol2qm74	4867	40	activated	activate	VBN
cord-015021-pol2qm74	4867	41	PMNL	PMNL	NNP
cord-015021-pol2qm74	4867	42	in	in	IN
cord-015021-pol2qm74	4867	43	arterial	arterial	JJ
cord-015021-pol2qm74	4867	44	circulation	circulation	NN
cord-015021-pol2qm74	4867	45	,	,	,
cord-015021-pol2qm74	4867	46	and	and	CC
cord-015021-pol2qm74	4867	47	3	3	LS
cord-015021-pol2qm74	4867	48	)	)	-RRB-
cord-015021-pol2qm74	4868	1	a	a	DT
cord-015021-pol2qm74	4868	2	significant	significant	JJ
cord-015021-pol2qm74	4868	3	arterial	arterial	JJ
cord-015021-pol2qm74	4868	4	increase	increase	NN
cord-015021-pol2qm74	4868	5	of	of	IN
cord-015021-pol2qm74	4868	6	PMNL	PMNL	NNP
cord-015021-pol2qm74	4868	7	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	4869	1	Ca	ca	NN
cord-015021-pol2qm74	4869	2	2	2	CD
cord-015021-pol2qm74	4869	3	+	+	CC
cord-015021-pol2qm74	4869	4	mobilization	mobilization	NN
cord-015021-pol2qm74	4869	5	after	after	IN
cord-015021-pol2qm74	4869	6	FMLP	FMLP	NNP
cord-015021-pol2qm74	4869	7	-	-	HYPH
cord-015021-pol2qm74	4869	8	stimulation	stimulation	NN
cord-015021-pol2qm74	4869	9	parallel	parallel	NN
cord-015021-pol2qm74	4869	10	to	to	IN
cord-015021-pol2qm74	4869	11	PMNL	PMNL	NNP
cord-015021-pol2qm74	4869	12	-	-	HYPH
cord-015021-pol2qm74	4869	13	activation	activation	NN
cord-015021-pol2qm74	4869	14	.	.	.
cord-015021-pol2qm74	4870	1	In	in	IN
cord-015021-pol2qm74	4870	2	conclusion	conclusion	NN
cord-015021-pol2qm74	4870	3	,	,	,
cord-015021-pol2qm74	4870	4	ischemia	ischemia	NN
cord-015021-pol2qm74	4870	5	/	/	SYM
cord-015021-pol2qm74	4870	6	reperfusion	reperfusion	NN
cord-015021-pol2qm74	4870	7	in	in	IN
cord-015021-pol2qm74	4870	8	man	man	NN
cord-015021-pol2qm74	4870	9	induces	induce	VBZ
cord-015021-pol2qm74	4870	10	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4870	11	damage	damage	NN
cord-015021-pol2qm74	4870	12	and	and	CC
cord-015021-pol2qm74	4870	13	activation	activation	NN
cord-015021-pol2qm74	4870	14	of	of	IN
cord-015021-pol2qm74	4870	15	PMNL	PMNL	NNP
cord-015021-pol2qm74	4870	16	superoxide	superoxide	NN
cord-015021-pol2qm74	4870	17	production	production	NN
cord-015021-pol2qm74	4870	18	possibly	possibly	RB
cord-015021-pol2qm74	4870	19	due	due	IN
cord-015021-pol2qm74	4870	20	to	to	IN
cord-015021-pol2qm74	4870	21	an	an	DT
cord-015021-pol2qm74	4870	22	altered	altered	JJ
cord-015021-pol2qm74	4870	23	PMNL-	pmnl-	NN
cord-015021-pol2qm74	4871	1	Ca	ca	NN
cord-015021-pol2qm74	4871	2	2	2	CD
cord-015021-pol2qm74	4871	3	+	+	CC
cord-015021-pol2qm74	4871	4	messenger	messenger	NN
cord-015021-pol2qm74	4871	5	system	system	NN
cord-015021-pol2qm74	4871	6	by	by	IN
cord-015021-pol2qm74	4871	7	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4871	8	mediators	mediator	NNS
cord-015021-pol2qm74	4871	9	(	(	-LRB-
cord-015021-pol2qm74	4871	10	e	e	NN
cord-015021-pol2qm74	4871	11	,	,	,
cord-015021-pol2qm74	4871	12	g	g	NN
cord-015021-pol2qm74	4871	13	.	.	.
cord-015021-pol2qm74	4871	14	II-8	II-8	NNP
cord-015021-pol2qm74	4871	15	,	,	,
cord-015021-pol2qm74	4871	16	TNF	TNF	NNP
cord-015021-pol2qm74	4871	17	,	,	,
cord-015021-pol2qm74	4871	18	PAF	PAF	NNP
cord-015021-pol2qm74	4871	19	)	)	-RRB-
cord-015021-pol2qm74	4871	20	.	.	.
cord-015021-pol2qm74	4872	1	The	the	DT
cord-015021-pol2qm74	4872	2	septic	septic	JJ
cord-015021-pol2qm74	4872	3	lung	lung	NN
cord-015021-pol2qm74	4872	4	diseases	disease	NNS
cord-015021-pol2qm74	4872	5	(	(	-LRB-
cord-015021-pol2qm74	4872	6	i.e.	i.e.	FW
cord-015021-pol2qm74	4872	7	ARDS	ARDS	NNP
cord-015021-pol2qm74	4872	8	)	)	-RRB-
cord-015021-pol2qm74	4872	9	generally	generally	RB
cord-015021-pol2qm74	4872	10	show	show	VBP
cord-015021-pol2qm74	4872	11	distinct	distinct	JJ
cord-015021-pol2qm74	4872	12	alveolar	alveolar	JJ
cord-015021-pol2qm74	4872	13	damage	damage	NN
cord-015021-pol2qm74	4872	14	and	and	CC
cord-015021-pol2qm74	4872	15	surfactant	surfactant	NN
cord-015021-pol2qm74	4872	16	disturbances	disturbance	NNS
cord-015021-pol2qm74	4872	17	.	.	.
cord-015021-pol2qm74	4873	1	It	-PRON-	PRP
cord-015021-pol2qm74	4873	2	is	be	VBZ
cord-015021-pol2qm74	4873	3	thought	think	VBN
cord-015021-pol2qm74	4873	4	that	that	IN
cord-015021-pol2qm74	4873	5	alveolar	alveolar	JJ
cord-015021-pol2qm74	4873	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	4873	7	are	be	VBP
cord-015021-pol2qm74	4873	8	involved	involve	VBN
cord-015021-pol2qm74	4873	9	in	in	IN
cord-015021-pol2qm74	4873	10	specific	specific	JJ
cord-015021-pol2qm74	4873	11	release	release	NN
cord-015021-pol2qm74	4873	12	products	product	NNS
cord-015021-pol2qm74	4873	13	like	like	IN
cord-015021-pol2qm74	4873	14	H202	H202	NNS
cord-015021-pol2qm74	4873	15	and	and	CC
cord-015021-pol2qm74	4873	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	4873	17	like	like	IN
cord-015021-pol2qm74	4873	18	TNF	TNF	NNP
cord-015021-pol2qm74	4873	19	.	.	.
cord-015021-pol2qm74	4874	1	In	in	IN
cord-015021-pol2qm74	4874	2	this	this	DT
cord-015021-pol2qm74	4874	3	pathway	pathway	NN
cord-015021-pol2qm74	4874	4	the	the	DT
cord-015021-pol2qm74	4874	5	type	type	NN
cord-015021-pol2qm74	4874	6	II	ii	CD
cord-015021-pol2qm74	4874	7	alveolar	alveolar	NN
cord-015021-pol2qm74	4874	8	epithelial	epithelial	JJ
cord-015021-pol2qm74	4874	9	cell	cell	NN
cord-015021-pol2qm74	4874	10	(	(	-LRB-
cord-015021-pol2qm74	4874	11	P2	p2	NN
cord-015021-pol2qm74	4874	12	cell	cell	NN
cord-015021-pol2qm74	4874	13	)	)	-RRB-
cord-015021-pol2qm74	4874	14	is	be	VBZ
cord-015021-pol2qm74	4874	15	not	not	RB
cord-015021-pol2qm74	4874	16	only	only	RB
cord-015021-pol2qm74	4874	17	an	an	DT
cord-015021-pol2qm74	4874	18	important	important	JJ
cord-015021-pol2qm74	4874	19	target	target	NN
cord-015021-pol2qm74	4874	20	,	,	,
cord-015021-pol2qm74	4874	21	but	but	CC
cord-015021-pol2qm74	4874	22	as	as	IN
cord-015021-pol2qm74	4874	23	recently	recently	RB
cord-015021-pol2qm74	4874	24	shown	show	VBN
cord-015021-pol2qm74	4874	25	it	-PRON-	PRP
cord-015021-pol2qm74	4874	26	is	be	VBZ
cord-015021-pol2qm74	4874	27	also	also	RB
cord-015021-pol2qm74	4874	28	capable	capable	JJ
cord-015021-pol2qm74	4874	29	of	of	IN
cord-015021-pol2qm74	4874	30	producing	produce	VBG
cord-015021-pol2qm74	4874	31	H202	H202	NNS
cord-015021-pol2qm74	4874	32	.	.	.
cord-015021-pol2qm74	4875	1	The	the	DT
cord-015021-pol2qm74	4875	2	aim	aim	NN
cord-015021-pol2qm74	4875	3	of	of	IN
cord-015021-pol2qm74	4875	4	this	this	DT
cord-015021-pol2qm74	4875	5	study	study	NN
cord-015021-pol2qm74	4875	6	was	be	VBD
cord-015021-pol2qm74	4875	7	to	to	TO
cord-015021-pol2qm74	4875	8	investigate	investigate	VB
cord-015021-pol2qm74	4875	9	the	the	DT
cord-015021-pol2qm74	4875	10	influence	influence	NN
cord-015021-pol2qm74	4875	11	of	of	IN
cord-015021-pol2qm74	4875	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4875	13	on	on	IN
cord-015021-pol2qm74	4875	14	H202	h202	NN
cord-015021-pol2qm74	4875	15	release	release	NN
cord-015021-pol2qm74	4875	16	of	of	IN
cord-015021-pol2qm74	4875	17	P2	P2	NNP
cord-015021-pol2qm74	4875	18	cells	cell	NNS
cord-015021-pol2qm74	4875	19	.	.	.
cord-015021-pol2qm74	4876	1	We	-PRON-	PRP
cord-015021-pol2qm74	4876	2	obtained	obtain	VBD
cord-015021-pol2qm74	4876	3	P2	P2	NNP
cord-015021-pol2qm74	4876	4	cells	cell	NNS
cord-015021-pol2qm74	4876	5	from	from	IN
cord-015021-pol2qm74	4876	6	lungs	lung	NNS
cord-015021-pol2qm74	4876	7	of	of	IN
cord-015021-pol2qm74	4876	8	female	female	JJ
cord-015021-pol2qm74	4876	9	wistar	wistar	NNP
cord-015021-pol2qm74	4876	10	rats	rat	NNS
cord-015021-pol2qm74	4876	11	and	and	CC
cord-015021-pol2qm74	4876	12	investigated	investigate	VBD
cord-015021-pol2qm74	4876	13	the	the	DT
cord-015021-pol2qm74	4876	14	effect	effect	NN
cord-015021-pol2qm74	4876	15	of	of	IN
cord-015021-pol2qm74	4876	16	lipopolysaccharid	lipopolysaccharid	NNP
cord-015021-pol2qm74	4876	17	(	(	-LRB-
cord-015021-pol2qm74	4876	18	LPS	LPS	NNP
cord-015021-pol2qm74	4876	19	)	)	-RRB-
cord-015021-pol2qm74	4876	20	on	on	IN
cord-015021-pol2qm74	4876	21	H202	h202	NN
cord-015021-pol2qm74	4876	22	release	release	NN
cord-015021-pol2qm74	4876	23	of	of	IN
cord-015021-pol2qm74	4876	24	fresh	fresh	JJ
cord-015021-pol2qm74	4876	25	isolated	isolated	JJ
cord-015021-pol2qm74	4876	26	cells	cell	NNS
cord-015021-pol2qm74	4876	27	and	and	CC
cord-015021-pol2qm74	4876	28	on	on	IN
cord-015021-pol2qm74	4876	29	cells	cell	NNS
cord-015021-pol2qm74	4876	30	cultured	culture	VBN
cord-015021-pol2qm74	4876	31	for	for	IN
cord-015021-pol2qm74	4876	32	2	2	CD
cord-015021-pol2qm74	4876	33	days	day	NNS
cord-015021-pol2qm74	4876	34	in	in	IN
cord-015021-pol2qm74	4876	35	a	a	DT
cord-015021-pol2qm74	4876	36	fibronectin	fibronectin	NN
cord-015021-pol2qm74	4876	37	matrix	matrix	NN
cord-015021-pol2qm74	4876	38	.	.	.
cord-015021-pol2qm74	4877	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	4877	2	we	-PRON-	PRP
cord-015021-pol2qm74	4877	3	conditioned	condition	VBD
cord-015021-pol2qm74	4877	4	isolated	isolated	JJ
cord-015021-pol2qm74	4877	5	alveolar	alveolar	JJ
cord-015021-pol2qm74	4877	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	4877	7	for	for	IN
cord-015021-pol2qm74	4877	8	16	16	CD
cord-015021-pol2qm74	4877	9	hours	hour	NNS
cord-015021-pol2qm74	4877	10	with	with	IN
cord-015021-pol2qm74	4877	11	1	1	CD
cord-015021-pol2qm74	4877	12	p.g	p.g	NNP
cord-015021-pol2qm74	4877	13	/	/	SYM
cord-015021-pol2qm74	4877	14	ml	ml	NNP
cord-015021-pol2qm74	4877	15	LPS	LPS	NNP
cord-015021-pol2qm74	4877	16	and	and	CC
cord-015021-pol2qm74	4877	17	tested	test	VBD
cord-015021-pol2qm74	4877	18	the	the	DT
cord-015021-pol2qm74	4877	19	conditioned	condition	VBN
cord-015021-pol2qm74	4877	20	medium	medium	NN
cord-015021-pol2qm74	4877	21	(	(	-LRB-
cord-015021-pol2qm74	4877	22	MCM	MCM	NNP
cord-015021-pol2qm74	4877	23	)	)	-RRB-
cord-015021-pol2qm74	4877	24	on	on	IN
cord-015021-pol2qm74	4877	25	cultured	cultured	JJ
cord-015021-pol2qm74	4877	26	P2	P2	NNP
cord-015021-pol2qm74	4877	27	cells	cell	NNS
cord-015021-pol2qm74	4877	28	.	.	.
cord-015021-pol2qm74	4878	1	P2	p2	NN
cord-015021-pol2qm74	4878	2	cells	cell	NNS
cord-015021-pol2qm74	4878	3	5	5	CD
cord-015021-pol2qm74	4878	4	h	h	NN
cord-015021-pol2qm74	4879	1	ex	ex	NNP
cord-015021-pol2qm74	4879	2	vivo	vivo	NNP
cord-015021-pol2qm74	4879	3	were	be	VBD
cord-015021-pol2qm74	4879	4	_	_	NN
cord-015021-pol2qm74	4879	5	>	>	XX
cord-015021-pol2qm74	4880	1	70	70	CD
cord-015021-pol2qm74	4880	2	%	%	NN
cord-015021-pol2qm74	4880	3	pure	pure	JJ
cord-015021-pol2qm74	4880	4	,	,	,
cord-015021-pol2qm74	4880	5	_	_	NN
cord-015021-pol2qm74	4880	6	>	>	XX
cord-015021-pol2qm74	4880	7	95	95	CD
cord-015021-pol2qm74	4880	8	%	%	NN
cord-015021-pol2qm74	4880	9	vital	vital	JJ
cord-015021-pol2qm74	4880	10	and	and	CC
cord-015021-pol2qm74	4880	11	had	have	VBD
cord-015021-pol2qm74	4880	12	an	an	DT
cord-015021-pol2qm74	4880	13	basal	basal	NN
cord-015021-pol2qm74	4880	14	H202	h202	NN
cord-015021-pol2qm74	4880	15	release	release	NN
cord-015021-pol2qm74	4880	16	of	of	IN
cord-015021-pol2qm74	4880	17	64.5	64.5	CD
cord-015021-pol2qm74	4880	18	_	_	NN
cord-015021-pol2qm74	4880	19	+	+	CC
cord-015021-pol2qm74	4881	1	1.8	1.8	CD
cord-015021-pol2qm74	4881	2	nmol	nmol	JJ
cord-015021-pol2qm74	4881	3	H202	h202	NN
cord-015021-pol2qm74	4881	4	per	per	IN
cord-015021-pol2qm74	4881	5	hour	hour	NN
cord-015021-pol2qm74	4881	6	and	and	CC
cord-015021-pol2qm74	4881	7	million	million	CD
cord-015021-pol2qm74	4881	8	cells	cell	NNS
cord-015021-pol2qm74	4881	9	.	.	.
cord-015021-pol2qm74	4882	1	Adding	add	VBG
cord-015021-pol2qm74	4882	2	1	1	CD
cord-015021-pol2qm74	4882	3	p.g	p.g	NNP
cord-015021-pol2qm74	4882	4	/	/	SYM
cord-015021-pol2qm74	4882	5	ml	ml	IN
cord-015021-pol2qm74	4882	6	LPS	LPS	NNP
cord-015021-pol2qm74	4882	7	to	to	IN
cord-015021-pol2qm74	4882	8	the	the	DT
cord-015021-pol2qm74	4882	9	incubation	incubation	NN
cord-015021-pol2qm74	4882	10	medium	medium	NN
cord-015021-pol2qm74	4882	11	the	the	DT
cord-015021-pol2qm74	4882	12	H202	h202	NN
cord-015021-pol2qm74	4882	13	release	release	NN
cord-015021-pol2qm74	4882	14	decreases	decrease	VBZ
cord-015021-pol2qm74	4882	15	slightly	slightly	RB
cord-015021-pol2qm74	4882	16	but	but	CC
cord-015021-pol2qm74	4882	17	significantly	significantly	RB
cord-015021-pol2qm74	4882	18	to	to	IN
cord-015021-pol2qm74	4882	19	54.2	54.2	CD
cord-015021-pol2qm74	4882	20	_	_	NN
cord-015021-pol2qm74	4882	21	+	+	SYM
cord-015021-pol2qm74	4882	22	2.3	2.3	CD
cord-015021-pol2qm74	4882	23	nmol	nmol	NN
cord-015021-pol2qm74	4882	24	.	.	.
cord-015021-pol2qm74	4883	1	Adding	add	VBG
cord-015021-pol2qm74	4883	2	0.3	0.3	CD
cord-015021-pol2qm74	4883	3	p.g	p.g	NNP
cord-015021-pol2qm74	4883	4	/	/	SYM
cord-015021-pol2qm74	4883	5	ml	ml	NNP
cord-015021-pol2qm74	4883	6	phorbol	phorbol	NNP
cord-015021-pol2qm74	4883	7	myristate	myristate	NNP
cord-015021-pol2qm74	4883	8	acetate	acetate	NNP
cord-015021-pol2qm74	4883	9	(	(	-LRB-
cord-015021-pol2qm74	4883	10	PMA	PMA	NNP
cord-015021-pol2qm74	4883	11	)	)	-RRB-
cord-015021-pol2qm74	4883	12	to	to	IN
cord-015021-pol2qm74	4883	13	the	the	DT
cord-015021-pol2qm74	4883	14	basal	basal	NN
cord-015021-pol2qm74	4883	15	incubation	incubation	NN
cord-015021-pol2qm74	4883	16	medium	medium	NN
cord-015021-pol2qm74	4884	1	the	the	DT
cord-015021-pol2qm74	4884	2	H202	H202	NNP
cord-015021-pol2qm74	4884	3	release	release	NN
cord-015021-pol2qm74	4884	4	increased	increase	VBD
cord-015021-pol2qm74	4884	5	3-fold	3-fold	CD
cord-015021-pol2qm74	4884	6	to	to	IN
cord-015021-pol2qm74	4884	7	148.3_+	148.3_+	CD
cord-015021-pol2qm74	4884	8	26	26	CD
cord-015021-pol2qm74	4884	9	nmol	nmol	NN
cord-015021-pol2qm74	4884	10	.	.	.
cord-015021-pol2qm74	4885	1	PMA	PMA	NNP
cord-015021-pol2qm74	4885	2	induced	induce	VBD
cord-015021-pol2qm74	4885	3	H202	h202	NN
cord-015021-pol2qm74	4885	4	release	release	NN
cord-015021-pol2qm74	4885	5	decreased	decrease	VBD
cord-015021-pol2qm74	4885	6	to	to	IN
cord-015021-pol2qm74	4885	7	128.3	128.3	CD
cord-015021-pol2qm74	4885	8	+	+	SYM
cord-015021-pol2qm74	4885	9	41.5	41.5	CD
cord-015021-pol2qm74	4885	10	nmol	nmol	NN
cord-015021-pol2qm74	4885	11	after	after	IN
cord-015021-pol2qm74	4885	12	addition	addition	NN
cord-015021-pol2qm74	4885	13	of	of	IN
cord-015021-pol2qm74	4885	14	1	1	CD
cord-015021-pol2qm74	4885	15	p.g	p.g	NNP
cord-015021-pol2qm74	4885	16	/	/	SYM
cord-015021-pol2qm74	4885	17	ml	ml	NN
cord-015021-pol2qm74	4885	18	LPS	lp	NNS
cord-015021-pol2qm74	4885	19	.	.	.
cord-015021-pol2qm74	4886	1	After	after	IN
cord-015021-pol2qm74	4886	2	2	2	CD
cord-015021-pol2qm74	4886	3	culture	culture	NN
cord-015021-pol2qm74	4886	4	days	day	NNS
cord-015021-pol2qm74	4886	5	the	the	DT
cord-015021-pol2qm74	4886	6	P2	P2	NNP
cord-015021-pol2qm74	4886	7	cells	cell	NNS
cord-015021-pol2qm74	4886	8	were	be	VBD
cord-015021-pol2qm74	4886	9	_	_	NN
cord-015021-pol2qm74	4886	10	>	>	XX
cord-015021-pol2qm74	4886	11	98	98	CD
cord-015021-pol2qm74	4886	12	%	%	NN
cord-015021-pol2qm74	4886	13	pure	pure	JJ
cord-015021-pol2qm74	4886	14	and	and	CC
cord-015021-pol2qm74	4886	15	showed	show	VBD
cord-015021-pol2qm74	4886	16	a	a	DT
cord-015021-pol2qm74	4886	17	PMA	PMA	NNP
cord-015021-pol2qm74	4886	18	inducible	inducible	JJ
cord-015021-pol2qm74	4886	19	H202	h202	NN
cord-015021-pol2qm74	4886	20	release	release	NN
cord-015021-pol2qm74	4886	21	of	of	IN
cord-015021-pol2qm74	4887	1	174.8	174.8	CD
cord-015021-pol2qm74	4887	2	_	_	NN
cord-015021-pol2qm74	4887	3	+	+	SYM
cord-015021-pol2qm74	4887	4	9.9	9.9	CD
cord-015021-pol2qm74	4887	5	nmoL	nmol	CD
cord-015021-pol2qm74	4888	1	Addition	addition	NN
cord-015021-pol2qm74	4888	2	of	of	IN
cord-015021-pol2qm74	4888	3	1	1	CD
cord-015021-pol2qm74	4889	1	p.g	p.g	NNP
cord-015021-pol2qm74	4889	2	/	/	SYM
cord-015021-pol2qm74	4889	3	ml	ml	NNP
cord-015021-pol2qm74	4889	4	LPS	LPS	NNP
cord-015021-pol2qm74	4889	5	had	have	VBD
cord-015021-pol2qm74	4889	6	the	the	DT
cord-015021-pol2qm74	4889	7	inverse	inverse	JJ
cord-015021-pol2qm74	4889	8	effect	effect	NN
cord-015021-pol2qm74	4889	9	as	as	IN
cord-015021-pol2qm74	4889	10	on	on	IN
cord-015021-pol2qm74	4889	11	freshly	freshly	RB
cord-015021-pol2qm74	4889	12	isolated	isolate	VBN
cord-015021-pol2qm74	4889	13	cells	cell	NNS
cord-015021-pol2qm74	4889	14	as	as	IN
cord-015021-pol2qm74	4889	15	it	-PRON-	PRP
cord-015021-pol2qm74	4889	16	increased	increase	VBD
cord-015021-pol2qm74	4889	17	the	the	DT
cord-015021-pol2qm74	4889	18	H202	h202	NN
cord-015021-pol2qm74	4889	19	release	release	NN
cord-015021-pol2qm74	4889	20	up	up	RP
cord-015021-pol2qm74	4889	21	to	to	IN
cord-015021-pol2qm74	4890	1	216.2	216.2	CD
cord-015021-pol2qm74	4890	2	_	_	NN
cord-015021-pol2qm74	4890	3	+	+	SYM
cord-015021-pol2qm74	4890	4	2.4	2.4	CD
cord-015021-pol2qm74	4890	5	nmol	nmol	NN
cord-015021-pol2qm74	4890	6	.	.	.
cord-015021-pol2qm74	4891	1	Addition	addition	NN
cord-015021-pol2qm74	4891	2	of	of	IN
cord-015021-pol2qm74	4891	3	MCM	MCM	NNP
cord-015021-pol2qm74	4891	4	to	to	IN
cord-015021-pol2qm74	4891	5	cultured	cultured	JJ
cord-015021-pol2qm74	4891	6	P2	P2	NNP
cord-015021-pol2qm74	4891	7	cells	cell	NNS
cord-015021-pol2qm74	4891	8	increases	increase	VBZ
cord-015021-pol2qm74	4891	9	PMA	PMA	NNP
cord-015021-pol2qm74	4891	10	-	-	HYPH
cord-015021-pol2qm74	4891	11	stimulated	stimulate	VBN
cord-015021-pol2qm74	4891	12	H202	h202	NN
cord-015021-pol2qm74	4891	13	release	release	NN
cord-015021-pol2qm74	4891	14	to	to	IN
cord-015021-pol2qm74	4891	15	223.3	223.3	CD
cord-015021-pol2qm74	4891	16	+	+	CC
cord-015021-pol2qm74	4891	17	_	_	NN
cord-015021-pol2qm74	4891	18	10.7	10.7	CD
cord-015021-pol2qm74	4891	19	nmol	nmol	NN
cord-015021-pol2qm74	4891	20	.	.	.
cord-015021-pol2qm74	4892	1	The	the	DT
cord-015021-pol2qm74	4892	2	release	release	NN
cord-015021-pol2qm74	4892	3	decreased	decrease	VBD
cord-015021-pol2qm74	4892	4	to	to	IN
cord-015021-pol2qm74	4892	5	191.9	191.9	CD
cord-015021-pol2qm74	4892	6	_	_	NN
cord-015021-pol2qm74	4892	7	+	+	SYM
cord-015021-pol2qm74	4892	8	2.4	2.4	CD
cord-015021-pol2qm74	4892	9	nmol	nmol	NN
cord-015021-pol2qm74	4892	10	when	when	WRB
cord-015021-pol2qm74	4892	11	an	an	DT
cord-015021-pol2qm74	4892	12	murine	murine	JJ
cord-015021-pol2qm74	4892	13	anti	anti	JJ
cord-015021-pol2qm74	4892	14	-	-	JJ
cord-015021-pol2qm74	4892	15	TNF	tnf	JJ
cord-015021-pol2qm74	4892	16	-	-	HYPH
cord-015021-pol2qm74	4892	17	alpha	alpha	NN
cord-015021-pol2qm74	4892	18	antibody	antibody	NN
cord-015021-pol2qm74	4892	19	was	be	VBD
cord-015021-pol2qm74	4892	20	added	add	VBN
cord-015021-pol2qm74	4892	21	.	.	.
cord-015021-pol2qm74	4893	1	Vitality	vitality	NN
cord-015021-pol2qm74	4893	2	of	of	IN
cord-015021-pol2qm74	4893	3	cultured	cultured	JJ
cord-015021-pol2qm74	4893	4	cells	cell	NNS
cord-015021-pol2qm74	4893	5	was	be	VBD
cord-015021-pol2qm74	4893	6	>	>	:
cord-015021-pol2qm74	4893	7	96	96	CD
cord-015021-pol2qm74	4893	8	%	%	NN
cord-015021-pol2qm74	4893	9	in	in	IN
cord-015021-pol2qm74	4893	10	all	all	DT
cord-015021-pol2qm74	4893	11	experiments	experiment	NNS
cord-015021-pol2qm74	4893	12	.	.	.
cord-015021-pol2qm74	4894	1	The	the	DT
cord-015021-pol2qm74	4894	2	results	result	NNS
cord-015021-pol2qm74	4894	3	show	show	VBP
cord-015021-pol2qm74	4894	4	that	that	IN
cord-015021-pol2qm74	4894	5	LPS	LPS	NNP
cord-015021-pol2qm74	4894	6	has	have	VBZ
cord-015021-pol2qm74	4894	7	an	an	DT
cord-015021-pol2qm74	4894	8	direct	direct	JJ
cord-015021-pol2qm74	4894	9	effect	effect	NN
cord-015021-pol2qm74	4894	10	on	on	IN
cord-015021-pol2qm74	4894	11	P2	P2	NNP
cord-015021-pol2qm74	4894	12	cells	cell	NNS
cord-015021-pol2qm74	4894	13	cultured	culture	VBN
cord-015021-pol2qm74	4894	14	on	on	IN
cord-015021-pol2qm74	4894	15	fibronectin	fibronectin	NN
cord-015021-pol2qm74	4894	16	.	.	.
cord-015021-pol2qm74	4895	1	We	-PRON-	PRP
cord-015021-pol2qm74	4895	2	conclude	conclude	VBP
cord-015021-pol2qm74	4895	3	that	that	IN
cord-015021-pol2qm74	4895	4	the	the	DT
cord-015021-pol2qm74	4895	5	observed	observed	JJ
cord-015021-pol2qm74	4895	6	additional	additional	JJ
cord-015021-pol2qm74	4895	7	stimulatory	stimulatory	JJ
cord-015021-pol2qm74	4895	8	effects	effect	NNS
cord-015021-pol2qm74	4895	9	of	of	IN
cord-015021-pol2qm74	4895	10	MCM	MCM	NNP
cord-015021-pol2qm74	4895	11	seems	seem	VBZ
cord-015021-pol2qm74	4895	12	to	to	TO
cord-015021-pol2qm74	4895	13	depend	depend	VB
cord-015021-pol2qm74	4895	14	on	on	IN
cord-015021-pol2qm74	4895	15	TNF	TNF	NNP
cord-015021-pol2qm74	4895	16	-	-	HYPH
cord-015021-pol2qm74	4895	17	alpha	alpha	NN
cord-015021-pol2qm74	4895	18	.	.	.
cord-015021-pol2qm74	4896	1	The	the	DT
cord-015021-pol2qm74	4896	2	induction	induction	NN
cord-015021-pol2qm74	4896	3	of	of	IN
cord-015021-pol2qm74	4896	4	H202	H202	NNP
cord-015021-pol2qm74	4896	5	release	release	NN
cord-015021-pol2qm74	4896	6	of	of	IN
cord-015021-pol2qm74	4896	7	P2	P2	NNP
cord-015021-pol2qm74	4896	8	cells	cell	NNS
cord-015021-pol2qm74	4896	9	could	could	MD
cord-015021-pol2qm74	4896	10	be	be	VB
cord-015021-pol2qm74	4896	11	important	important	JJ
cord-015021-pol2qm74	4896	12	for	for	IN
cord-015021-pol2qm74	4896	13	generating	generate	VBG
cord-015021-pol2qm74	4896	14	internal	internal	JJ
cord-015021-pol2qm74	4896	15	oxidative	oxidative	JJ
cord-015021-pol2qm74	4896	16	stress	stress	NN
cord-015021-pol2qm74	4896	17	in	in	IN
cord-015021-pol2qm74	4896	18	P2	P2	NNP
cord-015021-pol2qm74	4896	19	cells	cell	NNS
cord-015021-pol2qm74	4896	20	before	before	IN
cord-015021-pol2qm74	4896	21	external	external	JJ
cord-015021-pol2qm74	4896	22	oxygen	oxygen	NN
cord-015021-pol2qm74	4896	23	radicals	radical	NNS
cord-015021-pol2qm74	4896	24	exceed	exceed	VBP
cord-015021-pol2qm74	4896	25	.	.	.
cord-015021-pol2qm74	4897	1	The	the	DT
cord-015021-pol2qm74	4897	2	produced	produce	VBN
cord-015021-pol2qm74	4897	3	H202	h202	NN
cord-015021-pol2qm74	4897	4	did	do	VBD
cord-015021-pol2qm74	4897	5	not	not	RB
cord-015021-pol2qm74	4897	6	necessarily	necessarily	RB
cord-015021-pol2qm74	4897	7	damage	damage	VB
cord-015021-pol2qm74	4897	8	P2	P2	NNP
cord-015021-pol2qm74	4897	9	ceils	ceil	NNS
cord-015021-pol2qm74	4897	10	,	,	,
cord-015021-pol2qm74	4897	11	but	but	CC
cord-015021-pol2qm74	4897	12	it	-PRON-	PRP
cord-015021-pol2qm74	4897	13	can	can	MD
cord-015021-pol2qm74	4897	14	effect	effect	VB
cord-015021-pol2qm74	4897	15	surfactant	surfactant	NN
cord-015021-pol2qm74	4897	16	metabolism	metabolism	NN
cord-015021-pol2qm74	4897	17	,	,	,
cord-015021-pol2qm74	4897	18	especially	especially	RB
cord-015021-pol2qm74	4897	19	when	when	WRB
cord-015021-pol2qm74	4897	20	extracellular	extracellular	JJ
cord-015021-pol2qm74	4897	21	H202	h202	NN
cord-015021-pol2qm74	4897	22	release	release	NN
cord-015021-pol2qm74	4897	23	of	of	IN
cord-015021-pol2qm74	4897	24	alveolar	alveolar	JJ
cord-015021-pol2qm74	4897	25	macrophages	macrophage	NNS
cord-015021-pol2qm74	4897	26	following	follow	VBG
cord-015021-pol2qm74	4897	27	an	an	DT
cord-015021-pol2qm74	4897	28	immune	immune	JJ
cord-015021-pol2qm74	4897	29	response	response	NN
cord-015021-pol2qm74	4897	30	is	be	VBZ
cord-015021-pol2qm74	4897	31	increasing	increase	VBG
cord-015021-pol2qm74	4897	32	.	.	.
cord-015021-pol2qm74	4898	1	INTRODUCTION	introduction	NN
cord-015021-pol2qm74	4898	2	:	:	:
cord-015021-pol2qm74	4899	1	Primary	primary	JJ
cord-015021-pol2qm74	4899	2	stabilization	stabilization	NN
cord-015021-pol2qm74	4899	3	of	of	IN
cord-015021-pol2qm74	4899	4	femoral	femoral	JJ
cord-015021-pol2qm74	4899	5	shaft	shaft	NN
cord-015021-pol2qm74	4899	6	fractures	fracture	NNS
cord-015021-pol2qm74	4899	7	in	in	IN
cord-015021-pol2qm74	4899	8	patients	patient	NNS
cord-015021-pol2qm74	4899	9	with	with	IN
cord-015021-pol2qm74	4899	10	multiple	multiple	JJ
cord-015021-pol2qm74	4899	11	trauma	trauma	NN
cord-015021-pol2qm74	4899	12	is	be	VBZ
cord-015021-pol2qm74	4899	13	beneficial	beneficial	JJ
cord-015021-pol2qm74	4899	14	.	.	.
cord-015021-pol2qm74	4900	1	However	however	RB
cord-015021-pol2qm74	4900	2	,	,	,
cord-015021-pol2qm74	4900	3	in	in	IN
cord-015021-pol2qm74	4900	4	patients	patient	NNS
cord-015021-pol2qm74	4900	5	with	with	IN
cord-015021-pol2qm74	4900	6	associated	associated	JJ
cord-015021-pol2qm74	4900	7	lung	lung	NN
cord-015021-pol2qm74	4900	8	contusion	contusion	NN
cord-015021-pol2qm74	4900	9	we	-PRON-	PRP
cord-015021-pol2qm74	4900	10	have	have	VBP
cord-015021-pol2qm74	4900	11	found	find	VBN
cord-015021-pol2qm74	4900	12	an	an	DT
cord-015021-pol2qm74	4900	13	increased	increase	VBN
cord-015021-pol2qm74	4900	14	incidence	incidence	NN
cord-015021-pol2qm74	4900	15	of	of	IN
cord-015021-pol2qm74	4900	16	ARDS	ARDS	NNP
cord-015021-pol2qm74	4900	17	,	,	,
cord-015021-pol2qm74	4900	18	apparently	apparently	RB
cord-015021-pol2qm74	4900	19	associated	associate	VBN
cord-015021-pol2qm74	4900	20	with	with	IN
cord-015021-pol2qm74	4900	21	primary	primary	JJ
cord-015021-pol2qm74	4900	22	Reamed	Reamed	NNP
cord-015021-pol2qm74	4900	23	Femnral	Femnral	NNP
cord-015021-pol2qm74	4900	24	Nailing	nailing	NN
cord-015021-pol2qm74	4900	25	(	(	-LRB-
cord-015021-pol2qm74	4900	26	RFN	RFN	NNP
cord-015021-pol2qm74	4900	27	)	)	-RRB-
cord-015021-pol2qm74	4900	28	.	.	.
cord-015021-pol2qm74	4901	1	Previous	previous	JJ
cord-015021-pol2qm74	4901	2	animal	animal	NN
cord-015021-pol2qm74	4901	3	studies	study	NNS
cord-015021-pol2qm74	4901	4	revealed	reveal	VBD
cord-015021-pol2qm74	4901	5	,	,	,
cord-015021-pol2qm74	4901	6	that	that	IN
cord-015021-pol2qm74	4901	7	perioperative	perioperative	JJ
cord-015021-pol2qm74	4901	8	disturbances	disturbance	NNS
cord-015021-pol2qm74	4901	9	of	of	IN
cord-015021-pol2qm74	4901	10	lung	lung	NN
cord-015021-pol2qm74	4901	11	ftmetion	ftmetion	NN
cord-015021-pol2qm74	4901	12	appear	appear	VBP
cord-015021-pol2qm74	4901	13	to	to	TO
cord-015021-pol2qm74	4901	14	be	be	VB
cord-015021-pol2qm74	4901	15	related	relate	VBN
cord-015021-pol2qm74	4901	16	to	to	IN
cord-015021-pol2qm74	4901	17	the	the	DT
cord-015021-pol2qm74	4901	18	reaming	reaming	NN
cord-015021-pol2qm74	4901	19	procedure	procedure	NN
cord-015021-pol2qm74	4901	20	,	,	,
cord-015021-pol2qm74	4901	21	IX	IX	NNP
cord-015021-pol2qm74	4901	22	~	~	NFP
cord-015021-pol2qm74	4901	23	ssibly	ssibly	NNP
cord-015021-pol2qm74	4901	24	due	due	JJ
cord-015021-pol2qm74	4901	25	to	to	IN
cord-015021-pol2qm74	4901	26	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4901	27	embolizafion	embolizafion	NN
cord-015021-pol2qm74	4901	28	of	of	IN
cord-015021-pol2qm74	4901	29	bone	bone	NN
cord-015021-pol2qm74	4901	30	marrow	marrow	NN
cord-015021-pol2qm74	4901	31	fat	fat	NN
cord-015021-pol2qm74	4901	32	.	.	.
cord-015021-pol2qm74	4902	1	In	in	IN
cord-015021-pol2qm74	4902	2	a	a	DT
cord-015021-pol2qm74	4902	3	prospective	prospective	JJ
cord-015021-pol2qm74	4902	4	clinical	clinical	JJ
cord-015021-pol2qm74	4902	5	analysis	analysis	NN
cord-015021-pol2qm74	4902	6	we	-PRON-	PRP
cord-015021-pol2qm74	4902	7	compared	compare	VBD
cord-015021-pol2qm74	4902	8	effects	effect	NNS
cord-015021-pol2qm74	4902	9	of	of	IN
cord-015021-pol2qm74	4902	10	intrameduUary	intrameduuary	JJ
cord-015021-pol2qm74	4902	11	nailing	nail	VBG
cord-015021-pol2qm74	4902	12	with	with	IN
cord-015021-pol2qm74	4902	13	and	and	CC
cord-015021-pol2qm74	4902	14	withont	withont	JJ
cord-015021-pol2qm74	4902	15	reaming	reaming	NN
cord-015021-pol2qm74	4902	16	on	on	IN
cord-015021-pol2qm74	4902	17	parameters	parameter	NNS
cord-015021-pol2qm74	4902	18	known	know	VBN
cord-015021-pol2qm74	4902	19	to	to	TO
cord-015021-pol2qm74	4902	20	be	be	VB
cord-015021-pol2qm74	4902	21	related	relate	VBN
cord-015021-pol2qm74	4902	22	to	to	IN
cord-015021-pol2qm74	4902	23	ARDS	ARDS	NNP
cord-015021-pol2qm74	4902	24	-	-	HYPH
cord-015021-pol2qm74	4902	25	pathoganesis	pathoganesis	NNP
cord-015021-pol2qm74	4902	26	.	.	.
cord-015021-pol2qm74	4903	1	In	in	IN
cord-015021-pol2qm74	4903	2	order	order	NN
cord-015021-pol2qm74	4903	3	to	to	TO
cord-015021-pol2qm74	4903	4	gain	gain	VB
cord-015021-pol2qm74	4903	5	further	further	JJ
cord-015021-pol2qm74	4903	6	insight	insight	NN
cord-015021-pol2qm74	4903	7	into	into	IN
cord-015021-pol2qm74	4903	8	the	the	DT
cord-015021-pol2qm74	4903	9	role	role	NN
cord-015021-pol2qm74	4903	10	of	of	IN
cord-015021-pol2qm74	4903	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4903	12	and	and	CC
cord-015021-pol2qm74	4903	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	4903	14	in	in	IN
cord-015021-pol2qm74	4903	15	the	the	DT
cord-015021-pol2qm74	4903	16	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	4903	17	of	of	IN
cord-015021-pol2qm74	4903	18	the	the	DT
cord-015021-pol2qm74	4903	19	adult	adult	NN
cord-015021-pol2qm74	4903	20	respiratory	respiratory	JJ
cord-015021-pol2qm74	4903	21	distress	distress	NN
cord-015021-pol2qm74	4903	22	syndrome	syndrome	NN
cord-015021-pol2qm74	4903	23	(	(	-LRB-
cord-015021-pol2qm74	4903	24	ARDS	ARDS	NNP
cord-015021-pol2qm74	4903	25	)	)	-RRB-
cord-015021-pol2qm74	4903	26	,	,	,
cord-015021-pol2qm74	4903	27	we	-PRON-	PRP
cord-015021-pol2qm74	4903	28	enrolled	enrol	VBD
cord-015021-pol2qm74	4903	29	23	23	CD
cord-015021-pol2qm74	4903	30	patients	patient	NNS
cord-015021-pol2qm74	4903	31	with	with	IN
cord-015021-pol2qm74	4903	32	severe	severe	JJ
cord-015021-pol2qm74	4903	33	lung	lung	NN
cord-015021-pol2qm74	4903	34	injury	injury	NN
cord-015021-pol2qm74	4903	35	after	after	IN
cord-015021-pol2qm74	4903	36	sepsis	sepsis	NN
cord-015021-pol2qm74	4903	37	(	(	-LRB-
cord-015021-pol2qm74	4903	38	17	17	CD
cord-015021-pol2qm74	4903	39	)	)	-RRB-
cord-015021-pol2qm74	4903	40	or	or	CC
cord-015021-pol2qm74	4903	41	polytrauma	polytrauma	NNP
cord-015021-pol2qm74	4903	42	(	(	-LRB-
cord-015021-pol2qm74	4903	43	6	6	CD
cord-015021-pol2qm74	4903	44	)	)	-RRB-
cord-015021-pol2qm74	4903	45	and	and	CC
cord-015021-pol2qm74	4903	46	obtained	obtain	VBD
cord-015021-pol2qm74	4903	47	multiple	multiple	JJ
cord-015021-pol2qm74	4903	48	blood	blood	NN
cord-015021-pol2qm74	4903	49	samples	sample	NNS
cord-015021-pol2qm74	4903	50	(	(	-LRB-
cord-015021-pol2qm74	4903	51	14	14	CD
cord-015021-pol2qm74	4903	52	days	day	NNS
cord-015021-pol2qm74	4903	53	)	)	-RRB-
cord-015021-pol2qm74	4903	54	for	for	IN
cord-015021-pol2qm74	4903	55	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4903	56	,	,	,
cord-015021-pol2qm74	4903	57	tumor	tumor	NN
cord-015021-pol2qm74	4903	58	necrosis	necrosis	NN
cord-015021-pol2qm74	4903	59	factor	factor	NN
cord-015021-pol2qm74	4903	60	e	e	NNP
cord-015021-pol2qm74	4903	61	(	(	-LRB-
cord-015021-pol2qm74	4903	62	TNFa	TNFa	NNP
cord-015021-pol2qm74	4903	63	)	)	-RRB-
cord-015021-pol2qm74	4903	64	,	,	,
cord-015021-pol2qm74	4903	65	interleukin	interleukin	NN
cord-015021-pol2qm74	4903	66	18	18	CD
cord-015021-pol2qm74	4903	67	(	(	-LRB-
cord-015021-pol2qm74	4903	68	IL-18	IL-18	NNP
cord-015021-pol2qm74	4903	69	)	)	-RRB-
cord-015021-pol2qm74	4903	70	and	and	CC
cord-015021-pol2qm74	4903	71	interleukin	interleukin	NN
cord-015021-pol2qm74	4903	72	6	6	CD
cord-015021-pol2qm74	4903	73	(	(	-LRB-
cord-015021-pol2qm74	4903	74	IL-6	IL-6	NNP
cord-015021-pol2qm74	4903	75	)	)	-RRB-
cord-015021-pol2qm74	4903	76	determination	determination	NN
cord-015021-pol2qm74	4903	77	.	.	.
cord-015021-pol2qm74	4904	1	To	to	TO
cord-015021-pol2qm74	4904	2	evaluate	evaluate	VB
cord-015021-pol2qm74	4904	3	the	the	DT
cord-015021-pol2qm74	4904	4	cytokine	cytokine	NN
cord-015021-pol2qm74	4904	5	releasing	release	VBG
cord-015021-pol2qm74	4904	6	capacity	capacity	NN
cord-015021-pol2qm74	4904	7	of	of	IN
cord-015021-pol2qm74	4904	8	the	the	DT
cord-015021-pol2qm74	4904	9	blood	blood	NN
cord-015021-pol2qm74	4904	10	,	,	,
cord-015021-pol2qm74	4904	11	plasma	plasma	NN
cord-015021-pol2qm74	4904	12	concentrations	concentration	NNS
cord-015021-pol2qm74	4904	13	of	of	IN
cord-015021-pol2qm74	4904	14	TNFe	TNFe	NNS
cord-015021-pol2qm74	4904	15	,	,	,
cord-015021-pol2qm74	4904	16	IL	IL	NNP
cord-015021-pol2qm74	4904	17	-	-	HYPH
cord-015021-pol2qm74	4904	18	l8	l8	NNP
cord-015021-pol2qm74	4904	19	and	and	CC
cord-015021-pol2qm74	4904	20	IL-6	IL-6	NNP
cord-015021-pol2qm74	4904	21	were	be	VBD
cord-015021-pol2qm74	4904	22	also	also	RB
cord-015021-pol2qm74	4904	23	determined	determine	VBN
cord-015021-pol2qm74	4904	24	after	after	IN
cord-015021-pol2qm74	4904	25	the	the	DT
cord-015021-pol2qm74	4904	26	"	"	``
cord-015021-pol2qm74	4904	27	in	in	FW
cord-015021-pol2qm74	4904	28	vitro	vitro	FW
cord-015021-pol2qm74	4904	29	"	"	''
cord-015021-pol2qm74	4904	30	stimulation	stimulation	NN
cord-015021-pol2qm74	4904	31	of	of	IN
cord-015021-pol2qm74	4904	32	the	the	DT
cord-015021-pol2qm74	4904	33	whole	whole	JJ
cord-015021-pol2qm74	4904	34	blood	blood	NN
cord-015021-pol2qm74	4904	35	samples	sample	NNS
cord-015021-pol2qm74	4904	36	with	with	IN
cord-015021-pol2qm74	4904	37	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	4904	38	(	(	-LRB-
cord-015021-pol2qm74	4904	39	LPS	LPS	NNP
cord-015021-pol2qm74	4904	40	,	,	,
cord-015021-pol2qm74	4904	41	0.1	0.1	CD
cord-015021-pol2qm74	4904	42	ng	ng	NN
cord-015021-pol2qm74	4904	43	/	/	SYM
cord-015021-pol2qm74	4904	44	ml	ml	NN
cord-015021-pol2qm74	4904	45	)	)	-RRB-
cord-015021-pol2qm74	4904	46	for	for	IN
cord-015021-pol2qm74	4904	47	2	2	CD
cord-015021-pol2qm74	4904	48	hours	hour	NNS
cord-015021-pol2qm74	4904	49	at	at	IN
cord-015021-pol2qm74	4904	50	370	370	CD
cord-015021-pol2qm74	4904	51	C	c	NN
cord-015021-pol2qm74	4904	52	(	(	-LRB-
cord-015021-pol2qm74	4904	53	stimulated	stimulate	VBN
cord-015021-pol2qm74	4904	54	values	value	NNS
cord-015021-pol2qm74	4904	55	)	)	-RRB-
cord-015021-pol2qm74	4904	56	.	.	.
cord-015021-pol2qm74	4905	1	The	the	DT
cord-015021-pol2qm74	4905	2	difference	difference	NN
cord-015021-pol2qm74	4905	3	among	among	IN
cord-015021-pol2qm74	4905	4	stimulated	stimulate	VBN
cord-015021-pol2qm74	4905	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	4905	6	levels	level	NNS
cord-015021-pol2qm74	4905	7	and	and	CC
cord-015021-pol2qm74	4905	8	the	the	DT
cord-015021-pol2qm74	4905	9	basal	basal	NN
cord-015021-pol2qm74	4905	10	plasma	plasma	NN
cord-015021-pol2qm74	4905	11	concentrations	concentration	NNS
cord-015021-pol2qm74	4905	12	were	be	VBD
cord-015021-pol2qm74	4905	13	defined	define	VBN
cord-015021-pol2qm74	4905	14	as	as	IN
cord-015021-pol2qm74	4905	15	"	"	``
cord-015021-pol2qm74	4905	16	delta	delta	NN
cord-015021-pol2qm74	4905	17	values	value	NNS
cord-015021-pol2qm74	4905	18	"	"	''
cord-015021-pol2qm74	4905	19	,	,	,
cord-015021-pol2qm74	4905	20	an	an	DT
cord-015021-pol2qm74	4905	21	expression	expression	NN
cord-015021-pol2qm74	4905	22	of	of	IN
cord-015021-pol2qm74	4905	23	the	the	DT
cord-015021-pol2qm74	4905	24	cytokine	cytokine	NN
cord-015021-pol2qm74	4905	25	releasing	release	VBG
cord-015021-pol2qm74	4905	26	capacity	capacity	NN
cord-015021-pol2qm74	4905	27	of	of	IN
cord-015021-pol2qm74	4905	28	the	the	DT
cord-015021-pol2qm74	4905	29	blood	blood	NN
cord-015021-pol2qm74	4905	30	.	.	.
cord-015021-pol2qm74	4906	1	The	the	DT
cord-015021-pol2qm74	4906	2	pao2	pao2	NN
cord-015021-pol2qm74	4906	3	/	/	SYM
cord-015021-pol2qm74	4906	4	fiao2	fiao2	NN
cord-015021-pol2qm74	4906	5	quotient	quotient	NN
cord-015021-pol2qm74	4906	6	was	be	VBD
cord-015021-pol2qm74	4906	7	used	use	VBN
cord-015021-pol2qm74	4906	8	as	as	IN
cord-015021-pol2qm74	4906	9	an	an	DT
cord-015021-pol2qm74	4906	10	index	index	NN
cord-015021-pol2qm74	4906	11	of	of	IN
cord-015021-pol2qm74	4906	12	the	the	DT
cord-015021-pol2qm74	4906	13	severity	severity	NN
cord-015021-pol2qm74	4906	14	of	of	IN
cord-015021-pol2qm74	4906	15	lung	lung	NN
cord-015021-pol2qm74	4906	16	injury	injury	NN
cord-015021-pol2qm74	4906	17	(	(	-LRB-
cord-015021-pol2qm74	4906	18	SLI	SLI	NNP
cord-015021-pol2qm74	4906	19	)	)	-RRB-
cord-015021-pol2qm74	4906	20	.	.	.
cord-015021-pol2qm74	4907	1	The	the	DT
cord-015021-pol2qm74	4907	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4907	3	plasma	plasma	NN
cord-015021-pol2qm74	4907	4	level	level	NN
cord-015021-pol2qm74	4907	5	was	be	VBD
cord-015021-pol2qm74	4907	6	significantly	significantly	RB
cord-015021-pol2qm74	4907	7	higher	high	JJR
cord-015021-pol2qm74	4907	8	in	in	IN
cord-015021-pol2qm74	4907	9	patients	patient	NNS
cord-015021-pol2qm74	4907	10	with	with	IN
cord-015021-pol2qm74	4907	11	SLI	SLI	NNP
cord-015021-pol2qm74	4907	12	<	<	XX
cord-015021-pol2qm74	4907	13	200	200	CD
cord-015021-pol2qm74	4907	14	(	(	-LRB-
cord-015021-pol2qm74	4907	15	0.288	0.288	CD
cord-015021-pol2qm74	4908	1	±	±	NNP
cord-015021-pol2qm74	4908	2	0.038	0.038	CD
cord-015021-pol2qm74	4909	1	EU	EU	NNP
cord-015021-pol2qm74	4909	2	/	/	SYM
cord-015021-pol2qm74	4909	3	ml	ml	NN
cord-015021-pol2qm74	4909	4	,	,	,
cord-015021-pol2qm74	4910	1	mean	mean	JJ
cord-015021-pol2qm74	4910	2	values	value	NNS
cord-015021-pol2qm74	4910	3	±	±	NNP
cord-015021-pol2qm74	4910	4	SEM	SEM	NNP
cord-015021-pol2qm74	4910	5	)	)	-RRB-
cord-015021-pol2qm74	4910	6	versus	versus	IN
cord-015021-pol2qm74	4910	7	the	the	DT
cord-015021-pol2qm74	4910	8	patients	patient	NNS
cord-015021-pol2qm74	4910	9	with	with	IN
cord-015021-pol2qm74	4910	10	a	a	DT
cord-015021-pol2qm74	4910	11	SLI	sli	NN
cord-015021-pol2qm74	4911	1	>	>	XX
cord-015021-pol2qm74	4911	2	200	200	CD
cord-015021-pol2qm74	4911	3	(	(	-LRB-
cord-015021-pol2qm74	4911	4	0.175	0.175	CD
cord-015021-pol2qm74	4911	5	±	±	CD
cord-015021-pol2qm74	4911	6	0.023	0.023	CD
cord-015021-pol2qm74	4911	7	EU	EU	NNP
cord-015021-pol2qm74	4911	8	/	/	SYM
cord-015021-pol2qm74	4911	9	ml	ml	NN
cord-015021-pol2qm74	4911	10	,	,	,
cord-015021-pol2qm74	4911	11	p	p	NN
cord-015021-pol2qm74	4911	12	<	<	XX
cord-015021-pol2qm74	4911	13	O.01	o.01	CD
cord-015021-pol2qm74	4911	14	)	)	-RRB-
cord-015021-pol2qm74	4911	15	.	.	.
cord-015021-pol2qm74	4912	1	The	the	DT
cord-015021-pol2qm74	4912	2	basal	basal	NN
cord-015021-pol2qm74	4912	3	plasma	plasma	NN
cord-015021-pol2qm74	4912	4	concentration	concentration	NN
cord-015021-pol2qm74	4912	5	of	of	IN
cord-015021-pol2qm74	4912	6	ll-6	ll-6	NNP
cord-015021-pol2qm74	4912	7	also	also	RB
cord-015021-pol2qm74	4912	8	correlates	correlate	VBZ
cord-015021-pol2qm74	4912	9	with	with	IN
cord-015021-pol2qm74	4912	10	the	the	DT
cord-015021-pol2qm74	4912	11	SLI	SLI	NNP
cord-015021-pol2qm74	4912	12	index	index	NN
cord-015021-pol2qm74	4912	13	(	(	-LRB-
cord-015021-pol2qm74	4912	14	p	p	NN
cord-015021-pol2qm74	4912	15	<	<	XX
cord-015021-pol2qm74	4912	16	O.O01	o.o01	NN
cord-015021-pol2qm74	4912	17	)	)	-RRB-
cord-015021-pol2qm74	4912	18	.	.	.
cord-015021-pol2qm74	4913	1	The	the	DT
cord-015021-pol2qm74	4913	2	delta	delta	NN
cord-015021-pol2qm74	4913	3	TNFe	TNFe	NNS
cord-015021-pol2qm74	4913	4	and	and	CC
cord-015021-pol2qm74	4913	5	delta	delta	NNP
cord-015021-pol2qm74	4913	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	4913	7	values	value	NNS
cord-015021-pol2qm74	4913	8	were	be	VBD
cord-015021-pol2qm74	4913	9	s~	s~	CD
cord-015021-pol2qm74	4914	1	gnificantly	gnificantly	RB
cord-015021-pol2qm74	4914	2	decreased	decrease	VBD
cord-015021-pol2qm74	4914	3	in	in	IN
cord-015021-pol2qm74	4914	4	patients	patient	NNS
cord-015021-pol2qm74	4914	5	with	with	IN
cord-015021-pol2qm74	4914	6	a	a	DT
cord-015021-pol2qm74	4914	7	severe	severe	JJ
cord-015021-pol2qm74	4914	8	lung	lung	NN
cord-015021-pol2qm74	4914	9	injury	injury	NN
cord-015021-pol2qm74	4914	10	.	.	.
cord-015021-pol2qm74	4915	1	Compared	compare	VBN
cord-015021-pol2qm74	4915	2	with	with	IN
cord-015021-pol2qm74	4915	3	the	the	DT
cord-015021-pol2qm74	4915	4	survivors	survivor	NNS
cord-015021-pol2qm74	4915	5	(	(	-LRB-
cord-015021-pol2qm74	4915	6	n:11	n:11	CD
cord-015021-pol2qm74	4915	7	)	)	-RRB-
cord-015021-pol2qm74	4915	8	,	,	,
cord-015021-pol2qm74	4915	9	the	the	DT
cord-015021-pol2qm74	4915	10	deceased	deceased	JJ
cord-015021-pol2qm74	4915	11	patients	patient	NNS
cord-015021-pol2qm74	4915	12	(	(	-LRB-
cord-015021-pol2qm74	4915	13	n=12	n=12	NNP
cord-015021-pol2qm74	4915	14	)	)	-RRB-
cord-015021-pol2qm74	4915	15	showed	show	VBD
cord-015021-pol2qm74	4915	16	higher	high	JJR
cord-015021-pol2qm74	4915	17	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4915	18	level	level	NN
cord-015021-pol2qm74	4915	19	,	,	,
cord-015021-pol2qm74	4915	20	a	a	DT
cord-015021-pol2qm74	4915	21	reduced	reduce	VBN
cord-015021-pol2qm74	4915	22	TNFa	TNFa	NNS
cord-015021-pol2qm74	4915	23	and	and	CC
cord-015021-pol2qm74	4915	24	IL-6	IL-6	NNP
cord-015021-pol2qm74	4915	25	releasing	release	VBG
cord-015021-pol2qm74	4915	26	capacity	capacity	NN
cord-015021-pol2qm74	4915	27	of	of	IN
cord-015021-pol2qm74	4915	28	the	the	DT
cord-015021-pol2qm74	4915	29	blood	blood	NN
cord-015021-pol2qm74	4915	30	and	and	CC
cord-015021-pol2qm74	4915	31	higher	high	JJR
cord-015021-pol2qm74	4915	32	basal	basal	NN
cord-015021-pol2qm74	4915	33	IL-6	IL-6	NNP
cord-015021-pol2qm74	4915	34	levels	level	NNS
cord-015021-pol2qm74	4915	35	.	.	.
cord-015021-pol2qm74	4916	1	We	-PRON-	PRP
cord-015021-pol2qm74	4916	2	can	can	MD
cord-015021-pol2qm74	4916	3	conclude	conclude	VB
cord-015021-pol2qm74	4916	4	that	that	IN
cord-015021-pol2qm74	4916	5	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	4916	6	,	,	,
cord-015021-pol2qm74	4916	7	high	high	JJ
cord-015021-pol2qm74	4916	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	4916	9	plasma	plasma	NN
cord-015021-pol2qm74	4916	10	level	level	NN
cord-015021-pol2qm74	4916	11	and	and	CC
cord-015021-pol2qm74	4916	12	a	a	DT
cord-015021-pol2qm74	4916	13	decreased	decrease	VBN
cord-015021-pol2qm74	4916	14	capacity	capacity	NN
cord-015021-pol2qm74	4916	15	of	of	IN
cord-015021-pol2qm74	4916	16	the	the	DT
cord-015021-pol2qm74	4916	17	blood	blood	NN
cord-015021-pol2qm74	4916	18	to	to	TO
cord-015021-pol2qm74	4916	19	release	release	VB
cord-015021-pol2qm74	4916	20	TNFa	TNFa	NNS
cord-015021-pol2qm74	4916	21	an	an	DT
cord-015021-pol2qm74	4916	22	IL-6	IL-6	NNP
cord-015021-pol2qm74	4916	23	under	under	IN
cord-015021-pol2qm74	4916	24	endotoxin	endotoxin	NN
cord-015021-pol2qm74	4916	25	stimulation	stimulation	NN
cord-015021-pol2qm74	4916	26	associates	associate	NNS
cord-015021-pol2qm74	4916	27	with	with	IN
cord-015021-pol2qm74	4916	28	the	the	DT
cord-015021-pol2qm74	4916	29	severity	severity	NN
cord-015021-pol2qm74	4916	30	of	of	IN
cord-015021-pol2qm74	4916	31	lung	lung	NN
cord-015021-pol2qm74	4916	32	injury	injury	NN
cord-015021-pol2qm74	4916	33	.	.	.
cord-015021-pol2qm74	4917	1	[	[	-LRB-
cord-015021-pol2qm74	4917	2	Objectives	Objectives	NNP
cord-015021-pol2qm74	4917	3	]	]	-RRB-
cord-015021-pol2qm74	4917	4	Experimental	experimental	JJ
cord-015021-pol2qm74	4917	5	and	and	CC
cord-015021-pol2qm74	4917	6	clinical	clinical	JJ
cord-015021-pol2qm74	4917	7	findings	finding	NNS
cord-015021-pol2qm74	4917	8	implicate	implicate	VBP
cord-015021-pol2qm74	4917	9	the	the	DT
cord-015021-pol2qm74	4917	10	involvement	involvement	NN
cord-015021-pol2qm74	4917	11	of	of	IN
cord-015021-pol2qm74	4917	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	4917	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	4917	14	in	in	IN
cord-015021-pol2qm74	4917	15	the	the	DT
cord-015021-pol2qm74	4917	16	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	4917	17	of	of	IN
cord-015021-pol2qm74	4917	18	the	the	DT
cord-015021-pol2qm74	4917	19	decreased	decreased	JJ
cord-015021-pol2qm74	4917	20	oxygenation	oxygenation	NN
cord-015021-pol2qm74	4917	21	in	in	IN
cord-015021-pol2qm74	4917	22	the	the	DT
cord-015021-pol2qm74	4917	23	lung	lung	NN
cord-015021-pol2qm74	4917	24	after	after	IN
cord-015021-pol2qm74	4917	25	major	major	JJ
cord-015021-pol2qm74	4917	26	surgery	surgery	NN
cord-015021-pol2qm74	4917	27	,	,	,
cord-015021-pol2qm74	4917	28	though	though	IN
cord-015021-pol2qm74	4917	29	the	the	DT
cord-015021-pol2qm74	4917	30	mechanism	mechanism	NN
cord-015021-pol2qm74	4917	31	remains	remain	VBZ
cord-015021-pol2qm74	4917	32	unclear	unclear	JJ
cord-015021-pol2qm74	4917	33	.	.	.
cord-015021-pol2qm74	4918	1	In	in	IN
cord-015021-pol2qm74	4918	2	the	the	DT
cord-015021-pol2qm74	4918	3	present	present	JJ
cord-015021-pol2qm74	4918	4	study	study	NN
cord-015021-pol2qm74	4918	5	,	,	,
cord-015021-pol2qm74	4918	6	we	-PRON-	PRP
cord-015021-pol2qm74	4918	7	elucidated	elucidate	VBD
cord-015021-pol2qm74	4918	8	the	the	DT
cord-015021-pol2qm74	4918	9	involvement	involvement	NN
cord-015021-pol2qm74	4918	10	of	of	IN
cord-015021-pol2qm74	4918	11	IL-8	IL-8	NNP
cord-015021-pol2qm74	4918	12	in	in	IN
cord-015021-pol2qm74	4918	13	the	the	DT
cord-015021-pol2qm74	4918	14	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	4918	15	of	of	IN
cord-015021-pol2qm74	4918	16	lung	lung	NN
cord-015021-pol2qm74	4918	17	injury	injury	NN
cord-015021-pol2qm74	4918	18	defined	define	VBN
cord-015021-pol2qm74	4918	19	by	by	IN
cord-015021-pol2qm74	4918	20	deterioration	deterioration	NN
cord-015021-pol2qm74	4918	21	of	of	IN
cord-015021-pol2qm74	4918	22	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4918	23	oxygenation	oxygenation	NN
cord-015021-pol2qm74	4918	24	after	after	IN
cord-015021-pol2qm74	4918	25	esophagectomy	esophagectomy	NN
cord-015021-pol2qm74	4918	26	.	.	.
cord-015021-pol2qm74	4919	1	[	[	-LRB-
cord-015021-pol2qm74	4919	2	Materials	material	NNS
cord-015021-pol2qm74	4919	3	and	and	CC
cord-015021-pol2qm74	4919	4	Methods	Methods	NNPS
cord-015021-pol2qm74	4919	5	]	]	-RRB-
cord-015021-pol2qm74	4919	6	Seventeen	seventeen	CD
cord-015021-pol2qm74	4919	7	patients	patient	NNS
cord-015021-pol2qm74	4919	8	underwent	undergo	VBD
cord-015021-pol2qm74	4919	9	subtotal	subtotal	JJ
cord-015021-pol2qm74	4919	10	esophagectomy	esophagectomy	NN
cord-015021-pol2qm74	4919	11	through	through	IN
cord-015021-pol2qm74	4919	12	a	a	DT
cord-015021-pol2qm74	4919	13	right	right	JJ
cord-015021-pol2qm74	4919	14	thoracotomy	thoracotomy	NN
cord-015021-pol2qm74	4919	15	.	.	.
cord-015021-pol2qm74	4920	1	In	in	IN
cord-015021-pol2qm74	4920	2	all	all	DT
cord-015021-pol2qm74	4920	3	patients	patient	NNS
cord-015021-pol2qm74	4920	4	,	,	,
cord-015021-pol2qm74	4920	5	tbe	tbe	NN
cord-015021-pol2qm74	4920	6	alveolar	alveolar	NN
cord-015021-pol2qm74	4920	7	-	-	HYPH
cord-015021-pol2qm74	4920	8	arterial	arterial	JJ
cord-015021-pol2qm74	4920	9	oxygen	oxygen	NN
cord-015021-pol2qm74	4920	10	tension	tension	NN
cord-015021-pol2qm74	4920	11	difference	difference	NN
cord-015021-pol2qm74	4920	12	(	(	-LRB-
cord-015021-pol2qm74	4920	13	AaDO2	AaDO2	NNP
cord-015021-pol2qm74	4920	14	)	)	-RRB-
cord-015021-pol2qm74	4920	15	was	be	VBD
cord-015021-pol2qm74	4920	16	measured	measure	VBN
cord-015021-pol2qm74	4920	17	everyday	everyday	RB
cord-015021-pol2qm74	4920	18	and	and	CC
cord-015021-pol2qm74	4920	19	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	4920	20	lavage	lavage	NN
cord-015021-pol2qm74	4920	21	fluid	fluid	NN
cord-015021-pol2qm74	4920	22	(	(	-LRB-
cord-015021-pol2qm74	4920	23	BALF	BALF	NNP
cord-015021-pol2qm74	4920	24	)	)	-RRB-
cord-015021-pol2qm74	4920	25	samples	sample	NNS
cord-015021-pol2qm74	4920	26	were	be	VBD
cord-015021-pol2qm74	4920	27	obtained	obtain	VBN
cord-015021-pol2qm74	4920	28	from	from	IN
cord-015021-pol2qm74	4920	29	a	a	DT
cord-015021-pol2qm74	4920	30	single	single	JJ
cord-015021-pol2qm74	4920	31	segment	segment	NN
cord-015021-pol2qm74	4920	32	(	(	-LRB-
cord-015021-pol2qm74	4920	33	$	$	$
cord-015021-pol2qm74	4920	34	4	4	CD
cord-015021-pol2qm74	4920	35	or	or	CC
cord-015021-pol2qm74	4920	36	$	$	$
cord-015021-pol2qm74	4920	37	5	5	CD
cord-015021-pol2qm74	4920	38	)	)	-RRB-
cord-015021-pol2qm74	4920	39	of	of	IN
cord-015021-pol2qm74	4920	40	the	the	DT
cord-015021-pol2qm74	4920	41	right	right	NN
cord-015021-pol2qm74	4920	42	and	and	CC
cord-015021-pol2qm74	4920	43	left	leave	VBD
cord-015021-pol2qm74	4920	44	lung	lung	NN
cord-015021-pol2qm74	4920	45	through	through	IN
cord-015021-pol2qm74	4920	46	a	a	DT
cord-015021-pol2qm74	4920	47	bronchoscope	bronchoscope	NN
cord-015021-pol2qm74	4920	48	on	on	IN
cord-015021-pol2qm74	4920	49	days	day	NNS
cord-015021-pol2qm74	4920	50	l	l	NNP
cord-015021-pol2qm74	4920	51	,	,	,
cord-015021-pol2qm74	4920	52	3	3	CD
cord-015021-pol2qm74	4920	53	,	,	,
cord-015021-pol2qm74	4920	54	and	and	CC
cord-015021-pol2qm74	4920	55	5	5	CD
cord-015021-pol2qm74	4920	56	days	day	NNS
cord-015021-pol2qm74	4920	57	after	after	IN
cord-015021-pol2qm74	4920	58	surgery	surgery	NN
cord-015021-pol2qm74	4920	59	.	.	.
cord-015021-pol2qm74	4921	1	They	-PRON-	PRP
cord-015021-pol2qm74	4921	2	were	be	VBD
cord-015021-pol2qm74	4921	3	then	then	RB
cord-015021-pol2qm74	4921	4	examined	examine	VBN
cord-015021-pol2qm74	4921	5	for	for	IN
cord-015021-pol2qm74	4921	6	cell	cell	NN
cord-015021-pol2qm74	4921	7	analysis	analysis	NN
cord-015021-pol2qm74	4921	8	,	,	,
cord-015021-pol2qm74	4921	9	measurement	measurement	NN
cord-015021-pol2qm74	4921	10	of	of	IN
cord-015021-pol2qm74	4921	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	4921	12	by	by	IN
cord-015021-pol2qm74	4921	13	ELISA	ELISA	NNP
cord-015021-pol2qm74	4921	14	,	,	,
cord-015021-pol2qm74	4921	15	and	and	CC
cord-015021-pol2qm74	4921	16	measurement	measurement	NN
cord-015021-pol2qm74	4921	17	of	of	IN
cord-015021-pol2qm74	4921	18	neutrnphil	neutrnphil	NNP
cord-015021-pol2qm74	4921	19	elastase	elastase	NN
cord-015021-pol2qm74	4921	20	(	(	-LRB-
cord-015021-pol2qm74	4921	21	NE	NE	NNP
cord-015021-pol2qm74	4921	22	)	)	-RRB-
cord-015021-pol2qm74	4921	23	by	by	IN
cord-015021-pol2qm74	4921	24	ELISA	ELISA	NNP
cord-015021-pol2qm74	4921	25	.	.	.
cord-015021-pol2qm74	4922	1	[	[	-LRB-
cord-015021-pol2qm74	4922	2	Results	result	NNS
cord-015021-pol2qm74	4922	3	]	]	-RRB-
cord-015021-pol2qm74	4922	4	AaDO2	AaDO2	NNP
cord-015021-pol2qm74	4922	5	unexceptionally	unexceptionally	RB
cord-015021-pol2qm74	4922	6	deteriorated	deteriorate	VBD
cord-015021-pol2qm74	4922	7	postoperatively	postoperatively	RB
cord-015021-pol2qm74	4922	8	and	and	CC
cord-015021-pol2qm74	4922	9	the	the	DT
cord-015021-pol2qm74	4922	10	mean	mean	JJ
cord-015021-pol2qm74	4922	11	AaDO2	AaDO2	NNP
cord-015021-pol2qm74	4922	12	in	in	IN
cord-015021-pol2qm74	4922	13	17	17	CD
cord-015021-pol2qm74	4922	14	patients	patient	NNS
cord-015021-pol2qm74	4922	15	reached	reach	VBD
cord-015021-pol2qm74	4922	16	the	the	DT
cord-015021-pol2qm74	4922	17	maximum	maximum	NN
cord-015021-pol2qm74	4922	18	(	(	-LRB-
cord-015021-pol2qm74	4922	19	mean	mean	VB
cord-015021-pol2qm74	4922	20	±	±	NNP
cord-015021-pol2qm74	4922	21	SEM	SEM	NNP
cord-015021-pol2qm74	4922	22	;	;	:
cord-015021-pol2qm74	4922	23	372	372	CD
cord-015021-pol2qm74	4922	24	_	_	NN
cord-015021-pol2qm74	4922	25	+	+	SYM
cord-015021-pol2qm74	4922	26	23	23	CD
cord-015021-pol2qm74	4922	27	mmHg	mmHg	NNPS
cord-015021-pol2qm74	4922	28	)	)	-RRB-
cord-015021-pol2qm74	4922	29	on	on	IN
cord-015021-pol2qm74	4922	30	the	the	DT
cord-015021-pol2qm74	4922	31	3rd	3rd	JJ
cord-015021-pol2qm74	4922	32	postoperative	postoperative	JJ
cord-015021-pol2qm74	4922	33	day	day	NN
cord-015021-pol2qm74	4922	34	.	.	.
cord-015021-pol2qm74	4923	1	The	the	DT
cord-015021-pol2qm74	4923	2	mean	mean	JJ
cord-015021-pol2qm74	4923	3	concentrations	concentration	NNS
cord-015021-pol2qm74	4923	4	of	of	IN
cord-015021-pol2qm74	4923	5	IL-8	IL-8	NNP
cord-015021-pol2qm74	4923	6	,	,	,
cord-015021-pol2qm74	4923	7	NE	NE	NNP
cord-015021-pol2qm74	4923	8	and	and	CC
cord-015021-pol2qm74	4923	9	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4923	10	count	count	NN
cord-015021-pol2qm74	4923	11	in	in	IN
cord-015021-pol2qm74	4923	12	BALF	BALF	NNP
cord-015021-pol2qm74	4923	13	also	also	RB
cord-015021-pol2qm74	4923	14	increased	increase	VBD
cord-015021-pol2qm74	4923	15	postoperatively	postoperatively	RB
cord-015021-pol2qm74	4923	16	and	and	CC
cord-015021-pol2qm74	4923	17	reached	reach	VBD
cord-015021-pol2qm74	4923	18	their	-PRON-	PRP$
cord-015021-pol2qm74	4923	19	maximum	maximum	JJ
cord-015021-pol2qm74	4923	20	level	level	NN
cord-015021-pol2qm74	4923	21	(	(	-LRB-
cord-015021-pol2qm74	4923	22	2137	2137	CD
cord-015021-pol2qm74	4923	23	+	+	SYM
cord-015021-pol2qm74	4923	24	618	618	CD
cord-015021-pol2qm74	4923	25	pg	pg	NN
cord-015021-pol2qm74	4923	26	/	/	SYM
cord-015021-pol2qm74	4923	27	ml	ml	NNS
cord-015021-pol2qm74	4923	28	,	,	,
cord-015021-pol2qm74	4923	29	1603	1603	CD
cord-015021-pol2qm74	4923	30	-+	-+	SYM
cord-015021-pol2qm74	4923	31	493	493	CD
cord-015021-pol2qm74	4923	32	gg	gg	NNP
cord-015021-pol2qm74	4923	33	/	/	SYM
cord-015021-pol2qm74	4923	34	l	l	NN
cord-015021-pol2qm74	4923	35	,	,	,
cord-015021-pol2qm74	4923	36	and	and	CC
cord-015021-pol2qm74	4923	37	1561	1561	CD
cord-015021-pol2qm74	4923	38	±	±	CD
cord-015021-pol2qm74	4923	39	477	477	CD
cord-015021-pol2qm74	4923	40	x	x	SYM
cord-015021-pol2qm74	4923	41	103	103	CD
cord-015021-pol2qm74	4923	42	cells	cell	NNS
cord-015021-pol2qm74	4923	43	/	/	SYM
cord-015021-pol2qm74	4923	44	ml	ml	NNS
cord-015021-pol2qm74	4923	45	,	,	,
cord-015021-pol2qm74	4923	46	respectively	respectively	RB
cord-015021-pol2qm74	4923	47	)	)	-RRB-
cord-015021-pol2qm74	4923	48	on	on	IN
cord-015021-pol2qm74	4923	49	the	the	DT
cord-015021-pol2qm74	4923	50	3rd	3rd	JJ
cord-015021-pol2qm74	4923	51	postoperative	postoperative	JJ
cord-015021-pol2qm74	4923	52	day	day	NN
cord-015021-pol2qm74	4923	53	.	.	.
cord-015021-pol2qm74	4924	1	These	these	DT
cord-015021-pol2qm74	4924	2	increases	increase	NNS
cord-015021-pol2qm74	4924	3	in	in	IN
cord-015021-pol2qm74	4924	4	BALF	BALF	NNP
cord-015021-pol2qm74	4924	5	were	be	VBD
cord-015021-pol2qm74	4924	6	recognized	recognize	VBN
cord-015021-pol2qm74	4924	7	in	in	IN
cord-015021-pol2qm74	4924	8	both	both	CC
cord-015021-pol2qm74	4924	9	the	the	DT
cord-015021-pol2qm74	4924	10	right	right	NN
cord-015021-pol2qm74	4924	11	and	and	CC
cord-015021-pol2qm74	4924	12	left	left	JJ
cord-015021-pol2qm74	4924	13	lung	lung	NN
cord-015021-pol2qm74	4924	14	.	.	.
cord-015021-pol2qm74	4925	1	A	a	DT
cord-015021-pol2qm74	4925	2	highly	highly	RB
cord-015021-pol2qm74	4925	3	significant	significant	JJ
cord-015021-pol2qm74	4925	4	correlation	correlation	NN
cord-015021-pol2qm74	4925	5	was	be	VBD
cord-015021-pol2qm74	4925	6	observed	observe	VBN
cord-015021-pol2qm74	4925	7	between	between	IN
cord-015021-pol2qm74	4925	8	IL-8	IL-8	NNP
cord-015021-pol2qm74	4925	9	and	and	CC
cord-015021-pol2qm74	4925	10	NE	NE	NNP
cord-015021-pol2qm74	4925	11	levels	level	NNS
cord-015021-pol2qm74	4925	12	in	in	IN
cord-015021-pol2qm74	4925	13	BALF	BALF	NNP
cord-015021-pol2qm74	4925	14	(	(	-LRB-
cord-015021-pol2qm74	4925	15	r=0.82	r=0.82	NNP
cord-015021-pol2qm74	4925	16	,	,	,
cord-015021-pol2qm74	4925	17	p=0.0001	p=0.0001	NNP
cord-015021-pol2qm74	4925	18	)	)	-RRB-
cord-015021-pol2qm74	4925	19	.	.	.
cord-015021-pol2qm74	4926	1	Also	also	RB
cord-015021-pol2qm74	4926	2	,	,	,
cord-015021-pol2qm74	4926	3	significant	significant	JJ
cord-015021-pol2qm74	4926	4	correlations	correlation	NNS
cord-015021-pol2qm74	4926	5	between	between	IN
cord-015021-pol2qm74	4926	6	AaDO2	aado2	NN
cord-015021-pol2qm74	4926	7	and	and	CC
cord-015021-pol2qm74	4926	8	the	the	DT
cord-015021-pol2qm74	4926	9	neutropbil	neutropbil	NN
cord-015021-pol2qm74	4926	10	count	count	NN
cord-015021-pol2qm74	4926	11	,	,	,
cord-015021-pol2qm74	4926	12	and	and	CC
cord-015021-pol2qm74	4926	13	the	the	DT
cord-015021-pol2qm74	4926	14	concentration	concentration	NN
cord-015021-pol2qm74	4926	15	of	of	IN
cord-015021-pol2qm74	4926	16	NE	NE	NNP
cord-015021-pol2qm74	4926	17	or	or	CC
cord-015021-pol2qm74	4926	18	1L-8	1l-8	CD
cord-015021-pol2qm74	4926	19	were	be	VBD
cord-015021-pol2qm74	4926	20	observed	observe	VBN
cord-015021-pol2qm74	4926	21	.	.	.
cord-015021-pol2qm74	4927	1	In	in	IN
cord-015021-pol2qm74	4927	2	contrast	contrast	NN
cord-015021-pol2qm74	4927	3	to	to	IN
cord-015021-pol2qm74	4927	4	IL-8	IL-8	NNP
cord-015021-pol2qm74	4927	5	,	,	,
cord-015021-pol2qm74	4927	6	neither	neither	CC
cord-015021-pol2qm74	4927	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	4927	8	,	,	,
cord-015021-pol2qm74	4927	9	IL-113	il-113	NN
cord-015021-pol2qm74	4927	10	nor	nor	CC
cord-015021-pol2qm74	4927	11	TNFa	TNFa	NNP
cord-015021-pol2qm74	4927	12	was	be	VBD
cord-015021-pol2qm74	4927	13	detected	detect	VBN
cord-015021-pol2qm74	4927	14	in	in	IN
cord-015021-pol2qm74	4927	15	BALF	BALF	NNP
cord-015021-pol2qm74	4927	16	.	.	.
cord-015021-pol2qm74	4928	1	[	[	-LRB-
cord-015021-pol2qm74	4928	2	Conclusion	conclusion	NN
cord-015021-pol2qm74	4928	3	]	]	-RRB-
cord-015021-pol2qm74	4928	4	Major	major	JJ
cord-015021-pol2qm74	4928	5	surgical	surgical	JJ
cord-015021-pol2qm74	4928	6	trauma	trauma	NN
cord-015021-pol2qm74	4928	7	such	such	JJ
cord-015021-pol2qm74	4928	8	as	as	IN
cord-015021-pol2qm74	4928	9	esophagectomy	esophagectomy	NNP
cord-015021-pol2qm74	4928	10	may	may	MD
cord-015021-pol2qm74	4928	11	induce	induce	VB
cord-015021-pol2qm74	4928	12	recruitment	recruitment	NN
cord-015021-pol2qm74	4928	13	of	of	IN
cord-015021-pol2qm74	4928	14	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4928	15	to	to	IN
cord-015021-pol2qm74	4928	16	the	the	DT
cord-015021-pol2qm74	4928	17	lung	lung	NN
cord-015021-pol2qm74	4928	18	and	and	CC
cord-015021-pol2qm74	4928	19	cause	cause	VB
cord-015021-pol2qm74	4928	20	lung	lung	NN
cord-015021-pol2qm74	4928	21	injury	injury	NN
cord-015021-pol2qm74	4928	22	.	.	.
cord-015021-pol2qm74	4929	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	4929	2	increased	increase	VBD
cord-015021-pol2qm74	4929	3	in	in	IN
cord-015021-pol2qm74	4929	4	the	the	DT
cord-015021-pol2qm74	4929	5	lung	lung	NN
cord-015021-pol2qm74	4929	6	is	be	VBZ
cord-015021-pol2qm74	4929	7	an	an	DT
cord-015021-pol2qm74	4929	8	important	important	JJ
cord-015021-pol2qm74	4929	9	mediator	mediator	NN
cord-015021-pol2qm74	4929	10	of	of	IN
cord-015021-pol2qm74	4929	11	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4929	12	recruitment	recruitment	NN
cord-015021-pol2qm74	4929	13	and	and	CC
cord-015021-pol2qm74	4929	14	activation	activation	NN
cord-015021-pol2qm74	4929	15	in	in	IN
cord-015021-pol2qm74	4929	16	the	the	DT
cord-015021-pol2qm74	4929	17	lung	lung	NN
cord-015021-pol2qm74	4929	18	.	.	.
cord-015021-pol2qm74	4930	1	Phorbol	Phorbol	NNP
cord-015021-pol2qm74	4930	2	myristate	myristate	NN
cord-015021-pol2qm74	4930	3	acetate	acetate	NN
cord-015021-pol2qm74	4930	4	(	(	-LRB-
cord-015021-pol2qm74	4930	5	PMA	PMA	NNP
cord-015021-pol2qm74	4930	6	)	)	-RRB-
cord-015021-pol2qm74	4930	7	is	be	VBZ
cord-015021-pol2qm74	4930	8	commonly	commonly	RB
cord-015021-pol2qm74	4930	9	used	use	VBN
cord-015021-pol2qm74	4930	10	to	to	TO
cord-015021-pol2qm74	4930	11	cause	cause	VB
cord-015021-pol2qm74	4930	12	edema	edema	NN
cord-015021-pol2qm74	4930	13	and	and	CC
cord-015021-pol2qm74	4930	14	other	other	JJ
cord-015021-pol2qm74	4930	15	tissue	tissue	NN
cord-015021-pol2qm74	4930	16	damages	damage	NNS
cord-015021-pol2qm74	4930	17	in	in	IN
cord-015021-pol2qm74	4930	18	the	the	DT
cord-015021-pol2qm74	4930	19	lung	lung	NN
cord-015021-pol2qm74	4930	20	.	.	.
cord-015021-pol2qm74	4931	1	Lung	lung	NN
cord-015021-pol2qm74	4931	2	injuries	injury	NNS
cord-015021-pol2qm74	4931	3	induced	induce	VBN
cord-015021-pol2qm74	4931	4	by	by	IN
cord-015021-pol2qm74	4931	5	the	the	DT
cord-015021-pol2qm74	4931	6	administration	administration	NN
cord-015021-pol2qm74	4931	7	of	of	IN
cord-015021-pol2qm74	4931	8	PMA	PMA	NNP
cord-015021-pol2qm74	4931	9	has	have	VBZ
cord-015021-pol2qm74	4931	10	been	be	VBN
cord-015021-pol2qm74	4931	11	shown	show	VBN
cord-015021-pol2qm74	4931	12	to	to	TO
cord-015021-pol2qm74	4931	13	be	be	VB
cord-015021-pol2qm74	4931	14	mediated	mediate	VBN
cord-015021-pol2qm74	4931	15	mainly	mainly	RB
cord-015021-pol2qm74	4931	16	by	by	IN
cord-015021-pol2qm74	4931	17	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4931	18	.	.	.
cord-015021-pol2qm74	4932	1	Neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4932	2	recruited	recruit	VBN
cord-015021-pol2qm74	4932	3	to	to	IN
cord-015021-pol2qm74	4932	4	the	the	DT
cord-015021-pol2qm74	4932	5	lower	low	JJR
cord-015021-pol2qm74	4932	6	respiratory	respiratory	JJ
cord-015021-pol2qm74	4932	7	tract	tract	NN
cord-015021-pol2qm74	4932	8	may	may	MD
cord-015021-pol2qm74	4932	9	damage	damage	VB
cord-015021-pol2qm74	4932	10	lung	lung	NN
cord-015021-pol2qm74	4932	11	tissues	tissue	NNS
cord-015021-pol2qm74	4932	12	by	by	IN
cord-015021-pol2qm74	4932	13	releasing	release	VBG
cord-015021-pol2qm74	4932	14	reactive	reactive	JJ
cord-015021-pol2qm74	4932	15	oxygen	oxygen	NN
cord-015021-pol2qm74	4932	16	species	specie	NNS
cord-015021-pol2qm74	4932	17	,	,	,
cord-015021-pol2qm74	4932	18	neutral	neutral	JJ
cord-015021-pol2qm74	4932	19	proteases	protease	NNS
cord-015021-pol2qm74	4932	20	and	and	CC
cord-015021-pol2qm74	4932	21	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	4932	22	enzymes	enzyme	NNS
cord-015021-pol2qm74	4932	23	.	.	.
cord-015021-pol2qm74	4933	1	The	the	DT
cord-015021-pol2qm74	4933	2	present	present	JJ
cord-015021-pol2qm74	4933	3	study	study	NN
cord-015021-pol2qm74	4933	4	was	be	VBD
cord-015021-pol2qm74	4933	5	conducted	conduct	VBN
cord-015021-pol2qm74	4933	6	to	to	TO
cord-015021-pol2qm74	4933	7	investigate	investigate	VB
cord-015021-pol2qm74	4933	8	whether	whether	IN
cord-015021-pol2qm74	4933	9	c	c	NN
cord-015021-pol2qm74	4933	10	~	~	NFP
cord-015021-pol2qm74	4933	11	tocopherol	tocopherol	NN
cord-015021-pol2qm74	4933	12	,	,	,
cord-015021-pol2qm74	4933	13	entrapped	entrap	VBN
cord-015021-pol2qm74	4933	14	in	in	IN
cord-015021-pol2qm74	4933	15	dipalmitoylphosphatidylcholine	dipalmitoylphosphatidylcholine	NN
cord-015021-pol2qm74	4933	16	liposomes	liposome	NNS
cord-015021-pol2qm74	4933	17	and	and	CC
cord-015021-pol2qm74	4933	18	delivered	deliver	VBD
cord-015021-pol2qm74	4933	19	directly	directly	RB
cord-015021-pol2qm74	4933	20	to	to	IN
cord-015021-pol2qm74	4933	21	the	the	DT
cord-015021-pol2qm74	4933	22	lung	lung	NN
cord-015021-pol2qm74	4933	23	,	,	,
cord-015021-pol2qm74	4933	24	could	could	MD
cord-015021-pol2qm74	4933	25	counteract	counteract	VB
cord-015021-pol2qm74	4933	26	some	some	DT
cord-015021-pol2qm74	4933	27	of	of	IN
cord-015021-pol2qm74	4933	28	the	the	DT
cord-015021-pol2qm74	4933	29	PMA	PMA	NNP
cord-015021-pol2qm74	4933	30	-	-	HYPH
cord-015021-pol2qm74	4933	31	induced	induce	VBN
cord-015021-pol2qm74	4933	32	lung	lung	NN
cord-015021-pol2qm74	4933	33	injuries	injury	NNS
cord-015021-pol2qm74	4933	34	.	.	.
cord-015021-pol2qm74	4934	1	Plain	plain	JJ
cord-015021-pol2qm74	4934	2	liposomes	liposome	NNS
cord-015021-pol2qm74	4934	3	or	or	CC
cord-015021-pol2qm74	4934	4	c	c	NN
cord-015021-pol2qm74	4934	5	~	~	NFP
cord-015021-pol2qm74	4934	6	tocopherol	tocopherol	NN
cord-015021-pol2qm74	4934	7	-	-	HYPH
cord-015021-pol2qm74	4934	8	containing	contain	VBG
cord-015021-pol2qm74	4934	9	liposomes	liposome	NNS
cord-015021-pol2qm74	4934	10	(	(	-LRB-
cord-015021-pol2qm74	4934	11	8	8	CD
cord-015021-pol2qm74	4934	12	mg	mg	NNP
cord-015021-pol2qm74	4934	13	c~-tocopherol	c~-tocopherol	NNP
cord-015021-pol2qm74	4934	14	/	/	SYM
cord-015021-pol2qm74	4934	15	kgbody	kgbody	NNP
cord-015021-pol2qm74	4934	16	wt	wt	NNP
cord-015021-pol2qm74	4934	17	.	.	.
cord-015021-pol2qm74	4934	18	)	)	-RRB-
cord-015021-pol2qm74	4934	19	were	be	VBD
cord-015021-pol2qm74	4934	20	instilled	instill	VBN
cord-015021-pol2qm74	4934	21	into	into	IN
cord-015021-pol2qm74	4934	22	the	the	DT
cord-015021-pol2qm74	4934	23	lungs	lung	NNS
cord-015021-pol2qm74	4934	24	of	of	IN
cord-015021-pol2qm74	4934	25	rats	rat	NNS
cord-015021-pol2qm74	4934	26	24	24	CD
cord-015021-pol2qm74	4934	27	h	h	NN
cord-015021-pol2qm74	4934	28	prior	prior	RB
cord-015021-pol2qm74	4934	29	to	to	IN
cord-015021-pol2qm74	4934	30	PMA	PMA	NNP
cord-015021-pol2qm74	4934	31	exposure	exposure	NN
cord-015021-pol2qm74	4934	32	(	(	-LRB-
cord-015021-pol2qm74	4934	33	25	25	CD
cord-015021-pol2qm74	4934	34	pg	pg	NN
cord-015021-pol2qm74	4934	35	/	/	SYM
cord-015021-pol2qm74	4934	36	kg	kg	NNP
cord-015021-pol2qm74	4934	37	,	,	,
cord-015021-pol2qm74	4934	38	intratracheally	intratracheally	RB
cord-015021-pol2qm74	4934	39	)	)	-RRB-
cord-015021-pol2qm74	4934	40	and	and	CC
cord-015021-pol2qm74	4934	41	treated	treat	VBN
cord-015021-pol2qm74	4934	42	rats	rat	NNS
cord-015021-pol2qm74	4934	43	were	be	VBD
cord-015021-pol2qm74	4934	44	killed	kill	VBN
cord-015021-pol2qm74	4934	45	3	3	CD
cord-015021-pol2qm74	4934	46	h	h	NN
cord-015021-pol2qm74	4934	47	later	later	RB
cord-015021-pol2qm74	4934	48	.	.	.
cord-015021-pol2qm74	4935	1	Lungs	lung	NNS
cord-015021-pol2qm74	4935	2	of	of	IN
cord-015021-pol2qm74	4935	3	control	control	NN
cord-015021-pol2qm74	4935	4	animals	animal	NNS
cord-015021-pol2qm74	4935	5	exposed	expose	VBN
cord-015021-pol2qm74	4935	6	to	to	IN
cord-015021-pol2qm74	4935	7	PMA	PMA	NNP
cord-015021-pol2qm74	4935	8	developed	develop	VBD
cord-015021-pol2qm74	4935	9	increases	increase	NNS
cord-015021-pol2qm74	4935	10	in	in	IN
cord-015021-pol2qm74	4935	11	lung	lung	NN
cord-015021-pol2qm74	4935	12	weight	weight	NN
cord-015021-pol2qm74	4935	13	and	and	CC
cord-015021-pol2qm74	4935	14	lipid	lipid	NN
cord-015021-pol2qm74	4935	15	peroxidation	peroxidation	NN
cord-015021-pol2qm74	4935	16	as	as	RB
cord-015021-pol2qm74	4935	17	well	well	RB
cord-015021-pol2qm74	4935	18	as	as	IN
cord-015021-pol2qm74	4935	19	decreases	decrease	NNS
cord-015021-pol2qm74	4935	20	in	in	IN
cord-015021-pol2qm74	4935	21	lung	lung	NN
cord-015021-pol2qm74	4935	22	angiotensin	angiotensin	NN
cord-015021-pol2qm74	4935	23	converting	convert	VBG
cord-015021-pol2qm74	4935	24	enzyme	enzyme	NN
cord-015021-pol2qm74	4935	25	(	(	-LRB-
cord-015021-pol2qm74	4935	26	ACE	ace	NN
cord-015021-pol2qm74	4935	27	)	)	-RRB-
cord-015021-pol2qm74	4935	28	and	and	CC
cord-015021-pol2qm74	4935	29	alkaline	alkaline	JJ
cord-015021-pol2qm74	4935	30	phosphatase	phosphatase	NN
cord-015021-pol2qm74	4935	31	(	(	-LRB-
cord-015021-pol2qm74	4935	32	AKP	AKP	NNP
cord-015021-pol2qm74	4935	33	)	)	-RRB-
cord-015021-pol2qm74	4935	34	activities	activity	NNS
cord-015021-pol2qm74	4935	35	.	.	.
cord-015021-pol2qm74	4936	1	PMA	PMA	NNP
cord-015021-pol2qm74	4936	2	treatment	treatment	NN
cord-015021-pol2qm74	4936	3	also	also	RB
cord-015021-pol2qm74	4936	4	caused	cause	VBD
cord-015021-pol2qm74	4936	5	an	an	DT
cord-015021-pol2qm74	4936	6	increase	increase	NN
cord-015021-pol2qm74	4936	7	in	in	IN
cord-015021-pol2qm74	4936	8	myeloperoxidase	myeloperoxidase	NN
cord-015021-pol2qm74	4936	9	(	(	-LRB-
cord-015021-pol2qm74	4936	10	MPO	MPO	NNP
cord-015021-pol2qm74	4936	11	)	)	-RRB-
cord-015021-pol2qm74	4936	12	activity	activity	NN
cord-015021-pol2qm74	4936	13	in	in	IN
cord-015021-pol2qm74	4936	14	the	the	DT
cord-015021-pol2qm74	4936	15	lung	lung	NN
cord-015021-pol2qm74	4936	16	,	,	,
cord-015021-pol2qm74	4936	17	suggestive	suggestive	JJ
cord-015021-pol2qm74	4936	18	of	of	IN
cord-015021-pol2qm74	4936	19	neutrophi	neutrophi	JJ
cord-015021-pol2qm74	4936	20	]	]	-RRB-
cord-015021-pol2qm74	4936	21	infiltration	infiltration	NN
cord-015021-pol2qm74	4936	22	.	.	.
cord-015021-pol2qm74	4937	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	4937	2	of	of	IN
cord-015021-pol2qm74	4937	3	PMA	PMA	NNP
cord-015021-pol2qm74	4937	4	-	-	HYPH
cord-015021-pol2qm74	4937	5	treated	treat	VBN
cord-015021-pol2qm74	4937	6	rats	rat	NNS
cord-015021-pol2qm74	4937	7	with	with	IN
cord-015021-pol2qm74	4937	8	plain	plain	JJ
cord-015021-pol2qm74	4937	9	liposomes	liposome	NNS
cord-015021-pol2qm74	4937	10	had	have	VBD
cord-015021-pol2qm74	4937	11	no	no	DT
cord-015021-pol2qm74	4937	12	effect	effect	NN
cord-015021-pol2qm74	4937	13	on	on	IN
cord-015021-pol2qm74	4937	14	PMA	PMA	NNP
cord-015021-pol2qm74	4937	15	-	-	HYPH
cord-015021-pol2qm74	4937	16	induced	induce	VBN
cord-015021-pol2qm74	4937	17	injuries	injury	NNS
cord-015021-pol2qm74	4937	18	.	.	.
cord-015021-pol2qm74	4938	1	In	in	IN
cord-015021-pol2qm74	4938	2	contrast	contrast	NN
cord-015021-pol2qm74	4938	3	,	,	,
cord-015021-pol2qm74	4938	4	pretreatment	pretreatment	NN
cord-015021-pol2qm74	4938	5	of	of	IN
cord-015021-pol2qm74	4938	6	rats	rat	NNS
cord-015021-pol2qm74	4938	7	with	with	IN
cord-015021-pol2qm74	4938	8	liposomal	liposomal	JJ
cord-015021-pol2qm74	4938	9	c~-tocopherol	c~-tocopherol	NNP
cord-015021-pol2qm74	4938	10	,	,	,
cord-015021-pol2qm74	4938	11	24	24	CD
cord-015021-pol2qm74	4938	12	h	h	NN
cord-015021-pol2qm74	4938	13	prior	prior	RB
cord-015021-pol2qm74	4938	14	to	to	IN
cord-015021-pol2qm74	4938	15	PMA	PMA	NNP
cord-015021-pol2qm74	4938	16	administration	administration	NN
cord-015021-pol2qm74	4938	17	,	,	,
cord-015021-pol2qm74	4938	18	resulted	result	VBD
cord-015021-pol2qm74	4938	19	in	in	IN
cord-015021-pol2qm74	4938	20	a	a	DT
cord-015021-pol2qm74	4938	21	significant	significant	JJ
cord-015021-pol2qm74	4938	22	elevation	elevation	NN
cord-015021-pol2qm74	4938	23	of	of	IN
cord-015021-pol2qm74	4938	24	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4938	25	a	a	DT
cord-015021-pol2qm74	4938	26	-	-	HYPH
cord-015021-pol2qm74	4938	27	tocopherol	tocopherol	NN
cord-015021-pol2qm74	4938	28	concentration	concentration	NN
cord-015021-pol2qm74	4938	29	,	,	,
cord-015021-pol2qm74	4938	30	accompanied	accompany	VBN
cord-015021-pol2qm74	4938	31	by	by	IN
cord-015021-pol2qm74	4938	32	a	a	DT
cord-015021-pol2qm74	4938	33	concomitant	concomitant	JJ
cord-015021-pol2qm74	4938	34	reduction	reduction	NN
cord-015021-pol2qm74	4938	35	in	in	IN
cord-015021-pol2qm74	4938	36	MPO	MPO	NNP
cord-015021-pol2qm74	4938	37	activity	activity	NN
cord-015021-pol2qm74	4938	38	and	and	CC
cord-015021-pol2qm74	4938	39	reversal	reversal	NN
cord-015021-pol2qm74	4938	40	of	of	IN
cord-015021-pol2qm74	4938	41	PMAinduced	pmainduced	JJ
cord-015021-pol2qm74	4938	42	changes	change	NNS
cord-015021-pol2qm74	4938	43	in	in	IN
cord-015021-pol2qm74	4938	44	lung	lung	NN
cord-015021-pol2qm74	4938	45	edema	edema	NN
cord-015021-pol2qm74	4938	46	,	,	,
cord-015021-pol2qm74	4938	47	lipid	lipid	NN
cord-015021-pol2qm74	4938	48	peroxidation	peroxidation	NN
cord-015021-pol2qm74	4938	49	,	,	,
cord-015021-pol2qm74	4938	50	ACE	ACE	NNP
cord-015021-pol2qm74	4938	51	and	and	CC
cord-015021-pol2qm74	4938	52	AKP	AKP	NNP
cord-015021-pol2qm74	4938	53	activities	activity	NNS
cord-015021-pol2qm74	4938	54	.	.	.
cord-015021-pol2qm74	4939	1	These	these	DT
cord-015021-pol2qm74	4939	2	results	result	NNS
cord-015021-pol2qm74	4939	3	appear	appear	VBP
cord-015021-pol2qm74	4939	4	to	to	TO
cord-015021-pol2qm74	4939	5	demonstrate	demonstrate	VB
cord-015021-pol2qm74	4939	6	that	that	IN
cord-015021-pol2qm74	4939	7	the	the	DT
cord-015021-pol2qm74	4939	8	intratracheal	intratracheal	NNP
cord-015021-pol2qm74	4939	9	administration	administration	NNP
cord-015021-pol2qm74	4939	10	of	of	IN
cord-015021-pol2qm74	4939	11	a	a	DT
cord-015021-pol2qm74	4939	12	liposome	liposome	NN
cord-015021-pol2qm74	4939	13	-	-	HYPH
cord-015021-pol2qm74	4939	14	associated	associate	VBN
cord-015021-pol2qm74	4939	15	lipophilic	lipophilic	JJ
cord-015021-pol2qm74	4939	16	antioxidant	antioxidant	NN
cord-015021-pol2qm74	4939	17	,	,	,
cord-015021-pol2qm74	4939	18	such	such	JJ
cord-015021-pol2qm74	4939	19	as	as	IN
cord-015021-pol2qm74	4939	20	a	a	DT
cord-015021-pol2qm74	4939	21	-	-	HYPH
cord-015021-pol2qm74	4939	22	tocopherol	tocopherol	NN
cord-015021-pol2qm74	4939	23	,	,	,
cord-015021-pol2qm74	4939	24	can	can	MD
cord-015021-pol2qm74	4939	25	significantly	significantly	RB
cord-015021-pol2qm74	4939	26	ameliorate	ameliorate	VB
cord-015021-pol2qm74	4939	27	the	the	DT
cord-015021-pol2qm74	4939	28	toxic	toxic	JJ
cord-015021-pol2qm74	4939	29	effects	effect	NNS
cord-015021-pol2qm74	4939	30	of	of	IN
cord-015021-pol2qm74	4939	31	reactive	reactive	JJ
cord-015021-pol2qm74	4939	32	oxygen	oxygen	NN
cord-015021-pol2qm74	4939	33	species	specie	NNS
cord-015021-pol2qm74	4939	34	,	,	,
cord-015021-pol2qm74	4939	35	released	release	VBN
cord-015021-pol2qm74	4939	36	from	from	IN
cord-015021-pol2qm74	4939	37	PMAstimulated	PMAstimulated	NNP
cord-015021-pol2qm74	4939	38	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4939	39	target	target	NN
cord-015021-pol2qm74	4939	40	cells	cell	NNS
cord-015021-pol2qm74	4939	41	and	and	CC
cord-015021-pol2qm74	4939	42	infiltrating	infiltrate	VBG
cord-015021-pol2qm74	4939	43	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4939	44	.	.	.
cord-015021-pol2qm74	4940	1	JK	JK	NNP
cord-015021-pol2qm74	4940	2	Wojcik	Wojcik	NNP
cord-015021-pol2qm74	4940	3	,	,	,
cord-015021-pol2qm74	4940	4	G	G	NNP
cord-015021-pol2qm74	4940	5	Palasiewicz	Palasiewicz	NNP
cord-015021-pol2qm74	4940	6	,	,	,
cord-015021-pol2qm74	4940	7	W	W	NNP
cord-015021-pol2qm74	4940	8	Roszkowski	Roszkowski	NNP
cord-015021-pol2qm74	4940	9	Immunology	Immunology	NNP
cord-015021-pol2qm74	4940	10	Department	Department	NNP
cord-015021-pol2qm74	4940	11	,	,	,
cord-015021-pol2qm74	4940	12	Institute	Institute	NNP
cord-015021-pol2qm74	4940	13	of	of	IN
cord-015021-pol2qm74	4940	14	Tuberculosis	Tuberculosis	NNP
cord-015021-pol2qm74	4940	15	and	and	CC
cord-015021-pol2qm74	4940	16	Lung	Lung	NNP
cord-015021-pol2qm74	4940	17	Diseases~	Diseases~	.
cord-015021-pol2qm74	4941	1	Warszawa	Warszawa	NNP
cord-015021-pol2qm74	4941	2	,	,	,
cord-015021-pol2qm74	4941	3	Poland	Poland	NNP
cord-015021-pol2qm74	4941	4	,	,	,
cord-015021-pol2qm74	4941	5	M	M	NNP
cord-015021-pol2qm74	4941	6	~	~	NFP
cord-015021-pol2qm74	4941	7	larhospital	larhospital	NNP
cord-015021-pol2qm74	4941	8	,	,	,
cord-015021-pol2qm74	4941	9	Eskilstuna	Eskilstuna	NNP
cord-015021-pol2qm74	4941	10	,	,	,
cord-015021-pol2qm74	4941	11	Sweden	Sweden	NNP
cord-015021-pol2qm74	4941	12	.	.	.
cord-015021-pol2qm74	4942	1	Introduction	introduction	NN
cord-015021-pol2qm74	4942	2	:	:	:
cord-015021-pol2qm74	4943	1	The	the	DT
cord-015021-pol2qm74	4943	2	critical	critical	JJ
cord-015021-pol2qm74	4943	3	point	point	NN
cord-015021-pol2qm74	4943	4	in	in	IN
cord-015021-pol2qm74	4943	5	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4943	6	migration	migration	NN
cord-015021-pol2qm74	4943	7	to	to	IN
cord-015021-pol2qm74	4943	8	the	the	DT
cord-015021-pol2qm74	4943	9	alveolar	alveolar	JJ
cord-015021-pol2qm74	4943	10	space	space	NN
cord-015021-pol2qm74	4943	11	in	in	IN
cord-015021-pol2qm74	4943	12	the	the	DT
cord-015021-pol2qm74	4943	13	course	course	NN
cord-015021-pol2qm74	4943	14	of	of	IN
cord-015021-pol2qm74	4943	15	ARDS	ARDS	NNP
cord-015021-pol2qm74	4943	16	is	be	VBZ
cord-015021-pol2qm74	4943	17	the	the	DT
cord-015021-pol2qm74	4943	18	attachment	attachment	NN
cord-015021-pol2qm74	4943	19	between	between	IN
cord-015021-pol2qm74	4943	20	giyeoproteins	giyeoprotein	NNS
cord-015021-pol2qm74	4943	21	of	of	IN
cord-015021-pol2qm74	4943	22	neotrophil	neotrophil	NNP
cord-015021-pol2qm74	4943	23	membranes(sialyl	membranes(sialyl	DT
cord-015021-pol2qm74	4943	24	Lewis	Lewis	NNP
cord-015021-pol2qm74	4943	25	x	x	SYM
cord-015021-pol2qm74	4943	26	carbohydrate	carbohydrate	NN
cord-015021-pol2qm74	4943	27	epitope	epitope	NN
cord-015021-pol2qm74	4943	28	containing	contain	VBG
cord-015021-pol2qm74	4943	29	u	u	NNP
cord-015021-pol2qm74	4943	30	-	-	HYPH
cord-015021-pol2qm74	4943	31	l	l	NN
cord-015021-pol2qm74	4943	32	-	-	HYPH
cord-015021-pol2qm74	4943	33	fucose	fucose	NNP
cord-015021-pol2qm74	4943	34	)	)	-RRB-
cord-015021-pol2qm74	4943	35	and	and	CC
cord-015021-pol2qm74	4943	36	lectin	lectin	NN
cord-015021-pol2qm74	4943	37	domains	domain	NNS
cord-015021-pol2qm74	4943	38	of	of	IN
cord-015021-pol2qm74	4943	39	endothelial	endothelial	JJ
cord-015021-pol2qm74	4943	40	P	p	NN
cord-015021-pol2qm74	4943	41	and	and	CC
cord-015021-pol2qm74	4943	42	E	e	NN
cord-015021-pol2qm74	4943	43	selectins	selectin	NNS
cord-015021-pol2qm74	4943	44	(	(	-LRB-
cord-015021-pol2qm74	4943	45	GMP-140,ELAM	gmp-140,elam	NN
cord-015021-pol2qm74	4943	46	-	-	HYPH
cord-015021-pol2qm74	4943	47	I	i	NN
cord-015021-pol2qm74	4943	48	)	)	-RRB-
cord-015021-pol2qm74	4943	49	.	.	.
cord-015021-pol2qm74	4944	1	A	a	DT
cord-015021-pol2qm74	4944	2	potential	potential	JJ
cord-015021-pol2qm74	4944	3	beneficial	beneficial	JJ
cord-015021-pol2qm74	4944	4	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	4944	5	strategy	strategy	NN
cord-015021-pol2qm74	4944	6	may	may	MD
cord-015021-pol2qm74	4944	7	be	be	VB
cord-015021-pol2qm74	4944	8	designeP	designeP	NNP
cord-015021-pol2qm74	4944	9	to	to	TO
cord-015021-pol2qm74	4944	10	suppress	suppress	VB
cord-015021-pol2qm74	4944	11	neutrophil	neutrophil	NN
cord-015021-pol2qm74	4944	12	recruitment	recruitment	NN
cord-015021-pol2qm74	4944	13	to	to	IN
cord-015021-pol2qm74	4944	14	the	the	DT
cord-015021-pol2qm74	4944	15	lungs	lung	NNS
cord-015021-pol2qm74	4944	16	by	by	IN
cord-015021-pol2qm74	4944	17	preventing	prevent	VBG
cord-015021-pol2qm74	4944	18	their	-PRON-	PRP$
cord-015021-pol2qm74	4944	19	rolling	rolling	NN
cord-015021-pol2qm74	4944	20	and	and	CC
cord-015021-pol2qm74	4944	21	attachment	attachment	NN
cord-015021-pol2qm74	4944	22	to	to	IN
cord-015021-pol2qm74	4944	23	the	the	DT
cord-015021-pol2qm74	4944	24	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4944	25	endothelial	endothelial	JJ
cord-015021-pol2qm74	4944	26	cells	cell	NNS
cord-015021-pol2qm74	4944	27	.	.	.
cord-015021-pol2qm74	4945	1	ObjecLive	ObjecLive	NNP
cord-015021-pol2qm74	4945	2	:	:	:
cord-015021-pol2qm74	4946	1	To	to	TO
cord-015021-pol2qm74	4946	2	investigate	investigate	VB
cord-015021-pol2qm74	4946	3	if	if	IN
cord-015021-pol2qm74	4946	4	tz	tz	NNP
cord-015021-pol2qm74	4946	5	-	-	HYPH
cord-015021-pol2qm74	4946	6	l	l	NN
cord-015021-pol2qm74	4946	7	-	-	HYPH
cord-015021-pol2qm74	4946	8	fueose	fueose	VBN
cord-015021-pol2qm74	4946	9	prevent	prevent	JJ
cord-015021-pol2qm74	4946	10	experiments	experiment	NNS
cord-015021-pol2qm74	4946	11	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4946	12	hypertension	hypertension	NN
cord-015021-pol2qm74	4946	13	in	in	IN
cord-015021-pol2qm74	4946	14	ARDS	ARDS	NNP
cord-015021-pol2qm74	4946	15	as	as	IN
cord-015021-pol2qm74	4946	16	effective	effective	JJ
cord-015021-pol2qm74	4946	17	as	as	IN
cord-015021-pol2qm74	4946	18	metylpredniselone	metylpredniselone	NNP
cord-015021-pol2qm74	4946	19	.	.	.
cord-015021-pol2qm74	4947	1	Methods	method	NNS
cord-015021-pol2qm74	4947	2	:	:	:
cord-015021-pol2qm74	4947	3	Only	only	RB
cord-015021-pol2qm74	4947	4	healthy	healthy	JJ
cord-015021-pol2qm74	4947	5	rabbits	rabbit	NNS
cord-015021-pol2qm74	4947	6	(	(	-LRB-
cord-015021-pol2qm74	4947	7	N-24	N-24	NNP
cord-015021-pol2qm74	4947	8	)	)	-RRB-
cord-015021-pol2qm74	4947	9	weighing	weigh	VBG
cord-015021-pol2qm74	4947	10	5.D-5.5	5.d-5.5	CD
cord-015021-pol2qm74	4947	11	kg	kg	NNP
cord-015021-pol2qm74	4947	12	OaselinePaO>11	OaselinePaO>11	NNP
cord-015021-pol2qm74	4947	13	kPa	kPa	NNP
cord-015021-pol2qm74	4947	14	and	and	CC
cord-015021-pol2qm74	4947	15	mean	mean	VB
cord-015021-pol2qm74	4947	16	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4947	17	arterial	arterial	JJ
cord-015021-pol2qm74	4947	18	pressure	pressure	NN
cord-015021-pol2qm74	4947	19	(	(	-LRB-
cord-015021-pol2qm74	4947	20	MPAP)<I.5	MPAP)<I.5	NNP
cord-015021-pol2qm74	4947	21	kPa	kPa	NNP
cord-015021-pol2qm74	4947	22	were	be	VBD
cord-015021-pol2qm74	4947	23	included	include	VBN
cord-015021-pol2qm74	4947	24	in	in	IN
cord-015021-pol2qm74	4947	25	this	this	DT
cord-015021-pol2qm74	4947	26	study	study	NN
cord-015021-pol2qm74	4947	27	.	.	.
cord-015021-pol2qm74	4948	1	Anaesthesia	Anaesthesia	NNP
cord-015021-pol2qm74	4948	2	was	be	VBD
cord-015021-pol2qm74	4948	3	induced	induce	VBN
cord-015021-pol2qm74	4948	4	with	with	IN
cord-015021-pol2qm74	4948	5	Thiopental	Thiopental	NNP
cord-015021-pol2qm74	4948	6	20	20	CD
cord-015021-pol2qm74	4948	7	-	-	SYM
cord-015021-pol2qm74	4948	8	25	25	CD
cord-015021-pol2qm74	4948	9	mg	mg	NNP
cord-015021-pol2qm74	4948	10	/	/	SYM
cord-015021-pol2qm74	4948	11	kg	kg	NNP
cord-015021-pol2qm74	4948	12	bw	bw	NNP
cord-015021-pol2qm74	4948	13	and	and	CC
cord-015021-pol2qm74	4948	14	"	"	``
cord-015021-pol2qm74	4948	15	blind	blind	JJ
cord-015021-pol2qm74	4948	16	"	"	''
cord-015021-pol2qm74	4948	17	Jntubation	Jntubation	NNP
cord-015021-pol2qm74	4948	18	was	be	VBD
cord-015021-pol2qm74	4948	19	performed	perform	VBN
cord-015021-pol2qm74	4948	20	.	.	.
cord-015021-pol2qm74	4949	1	A	a	DT
cord-015021-pol2qm74	4949	2	5F	5f	NN
cord-015021-pol2qm74	4949	3	Swan	Swan	NNP
cord-015021-pol2qm74	4949	4	Ganz	Ganz	NNP
cord-015021-pol2qm74	4949	5	catheter	catheter	NN
cord-015021-pol2qm74	4949	6	was	be	VBD
cord-015021-pol2qm74	4949	7	introduced	introduce	VBN
cord-015021-pol2qm74	4949	8	via	via	IN
cord-015021-pol2qm74	4949	9	the	the	DT
cord-015021-pol2qm74	4949	10	left	left	JJ
cord-015021-pol2qm74	4949	11	jugular	jugular	NN
cord-015021-pol2qm74	4949	12	vein	vein	NN
cord-015021-pol2qm74	4949	13	into	into	IN
cord-015021-pol2qm74	4949	14	the	the	DT
cord-015021-pol2qm74	4949	15	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4949	16	artery	artery	NN
cord-015021-pol2qm74	4949	17	.	.	.
cord-015021-pol2qm74	4950	1	PMA	PMA	NNP
cord-015021-pol2qm74	4950	2	,	,	,
cord-015021-pol2qm74	4950	3	as	as	IN
cord-015021-pol2qm74	4950	4	was	be	VBD
cord-015021-pol2qm74	4950	5	used	use	VBN
cord-015021-pol2qm74	4950	6	in	in	IN
cord-015021-pol2qm74	4950	7	our	-PRON-	PRP$
cord-015021-pol2qm74	4950	8	experiments	experiment	NNS
cord-015021-pol2qm74	4950	9	activates	activate	VBZ
cord-015021-pol2qm74	4950	10	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4950	11	and	and	CC
cord-015021-pol2qm74	4950	12	produces	produce	VBZ
cord-015021-pol2qm74	4950	13	acute	acute	JJ
cord-015021-pol2qm74	4950	14	respiratory	respiratory	JJ
cord-015021-pol2qm74	4950	15	failure	failure	NN
cord-015021-pol2qm74	4950	16	with	with	IN
cord-015021-pol2qm74	4950	17	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4950	18	hypertension	hypertension	NN
cord-015021-pol2qm74	4950	19	and	and	CC
cord-015021-pol2qm74	4950	20	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4950	21	edema	edema	NN
cord-015021-pol2qm74	4950	22	.	.	.
cord-015021-pol2qm74	4951	1	Eight	eight	CD
cord-015021-pol2qm74	4951	2	rabbits	rabbit	NNS
cord-015021-pol2qm74	4951	3	serving	serve	VBG
cord-015021-pol2qm74	4951	4	as	as	IN
cord-015021-pol2qm74	4951	5	control	control	NN
cord-015021-pol2qm74	4951	6	animals	animal	NNS
cord-015021-pol2qm74	4951	7	received	receive	VBD
cord-015021-pol2qm74	4951	8	PMA	PMA	NNP
cord-015021-pol2qm74	4951	9	25	25	CD
cord-015021-pol2qm74	4951	10	ug	ug	NNP
cord-015021-pol2qm74	4951	11	/	/	SYM
cord-015021-pol2qm74	4951	12	kg	kg	NNP
cord-015021-pol2qm74	4952	1	bw	bw	NNP
cord-015021-pol2qm74	4953	1	iv	iv	LS
cord-015021-pol2qm74	4953	2	only	only	RB
cord-015021-pol2qm74	4953	3	.	.	.
cord-015021-pol2qm74	4954	1	Sixteen	sixteen	CD
cord-015021-pol2qm74	4954	2	other	other	JJ
cord-015021-pol2qm74	4954	3	animals	animal	NNS
cord-015021-pol2qm74	4954	4	were	be	VBD
cord-015021-pol2qm74	4954	5	divided	divide	VBN
cord-015021-pol2qm74	4954	6	into	into	IN
cord-015021-pol2qm74	4954	7	two	two	CD
cord-015021-pol2qm74	4954	8	groups	group	NNS
cord-015021-pol2qm74	4954	9	receiving	receive	VBG
cord-015021-pol2qm74	4954	10	either	either	CC
cord-015021-pol2qm74	4954	11	~-l	~-l	NNP
cord-015021-pol2qm74	4954	12	-	-	HYPH
cord-015021-pol2qm74	4954	13	fucose	fucose	NNP
cord-015021-pol2qm74	4955	1	100	100	CD
cord-015021-pol2qm74	4955	2	mg	mg	NNP
cord-015021-pol2qm74	4955	3	iv	iv	CD
cord-015021-pol2qm74	4955	4	or	or	CC
cord-015021-pol2qm74	4955	5	metylprednisolone	metylprednisolone	NN
cord-015021-pol2qm74	4955	6	150	150	CD
cord-015021-pol2qm74	4955	7	mg	mg	NNP
cord-015021-pol2qm74	4955	8	iv	iv	CD
cord-015021-pol2qm74	4955	9	15	15	CD
cord-015021-pol2qm74	4955	10	min	min	NNP
cord-015021-pol2qm74	4955	11	before	before	IN
cord-015021-pol2qm74	4955	12	PMA	PMA	NNP
cord-015021-pol2qm74	4955	13	admininstration	admininstration	NNP
cord-015021-pol2qm74	4955	14	.	.	.
cord-015021-pol2qm74	4956	1	Results	result	NNS
cord-015021-pol2qm74	4956	2	:	:	:
cord-015021-pol2qm74	4957	1	After	after	IN
cord-015021-pol2qm74	4957	2	PMA	PMA	NNP
cord-015021-pol2qm74	4957	3	administration	administration	NN
cord-015021-pol2qm74	4957	4	notable	notable	JJ
cord-015021-pol2qm74	4957	5	physiological	physiological	JJ
cord-015021-pol2qm74	4957	6	changes	change	NNS
cord-015021-pol2qm74	4957	7	including	include	VBG
cord-015021-pol2qm74	4957	8	marked	marked	JJ
cord-015021-pol2qm74	4957	9	increase	increase	NN
cord-015021-pol2qm74	4957	10	in	in	IN
cord-015021-pol2qm74	4957	11	MPAP(2.0-+O.~6	MPAP(2.0-+O.~6	NNP
cord-015021-pol2qm74	4957	12	kPe3	kPe3	NNPS
cord-015021-pol2qm74	4957	13	..	..	NFP
cord-015021-pol2qm74	4957	14	lere	lere	NNP
cord-015021-pol2qm74	4957	15	found	find	VBD
cord-015021-pol2qm74	4957	16	.	.	.
cord-015021-pol2qm74	4958	1	The	the	DT
cord-015021-pol2qm74	4958	2	increase	increase	NN
cord-015021-pol2qm74	4958	3	of	of	IN
cord-015021-pol2qm74	4958	4	NPAP	NPAP	NNP
cord-015021-pol2qm74	4958	5	was	be	VBD
cord-015021-pol2qm74	4958	6	observed	observe	VBN
cord-015021-pol2qm74	4958	7	to	to	TO
cord-015021-pol2qm74	4958	8	be	be	VB
cord-015021-pol2qm74	4958	9	completely	completely	RB
cord-015021-pol2qm74	4958	10	blocked	block	VBN
cord-015021-pol2qm74	4958	11	in	in	IN
cord-015021-pol2qm74	4958	12	both	both	DT
cord-015021-pol2qm74	4958	13	groups	group	NNS
cord-015021-pol2qm74	4958	14	of	of	IN
cord-015021-pol2qm74	4958	15	animals	animal	NNS
cord-015021-pol2qm74	4958	16	which	which	WDT
cord-015021-pol2qm74	4958	17	received	receive	VBD
cord-015021-pol2qm74	4958	18	~-l	~-l	NNP
cord-015021-pol2qm74	4958	19	-	-	HYPH
cord-015021-pol2qm74	4958	20	fucose	fucose	NNP
cord-015021-pol2qm74	4958	21	or	or	CC
cord-015021-pol2qm74	4958	22	metylprednisolone	metylprednisolone	NN
cord-015021-pol2qm74	4958	23	.	.	.
cord-015021-pol2qm74	4959	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	4959	2	:	:	:
cord-015021-pol2qm74	4960	1	In	in	IN
cord-015021-pol2qm74	4960	2	aur	aur	NNP
cord-015021-pol2qm74	4960	3	rabbit	rabbit	NN
cord-015021-pol2qm74	4960	4	model	model	NN
cord-015021-pol2qm74	4960	5	ARDS	ARDS	NNP
cord-015021-pol2qm74	4960	6	CZ	CZ	NNP
cord-015021-pol2qm74	4960	7	-	-	HYPH
cord-015021-pol2qm74	4960	8	l	l	NNP
cord-015021-pol2qm74	4960	9	-	-	HYPH
cord-015021-pol2qm74	4960	10	fucose	fucose	JJ
cord-015021-pol2qm74	4960	11	pretreatment	pretreatment	NN
cord-015021-pol2qm74	4960	12	prevents	prevent	VBZ
cord-015021-pol2qm74	4960	13	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4960	14	hypertension	hypertension	NN
cord-015021-pol2qm74	4960	15	after	after	IN
cord-015021-pol2qm74	4960	16	PMA	PMA	NNP
cord-015021-pol2qm74	4960	17	administration	administration	NN
cord-015021-pol2qm74	4960	18	.	.	.
cord-015021-pol2qm74	4961	1	The	the	DT
cord-015021-pol2qm74	4961	2	effect	effect	NN
cord-015021-pol2qm74	4961	3	is	be	VBZ
cord-015021-pol2qm74	4961	4	comparable	comparable	JJ
cord-015021-pol2qm74	4961	5	with	with	IN
cord-015021-pol2qm74	4961	6	high	high	JJ
cord-015021-pol2qm74	4961	7	dose	dose	NN
cord-015021-pol2qm74	4961	8	metylprednisolone	metylprednisolone	NN
cord-015021-pol2qm74	4961	9	.	.	.
cord-015021-pol2qm74	4962	1	The	the	DT
cord-015021-pol2qm74	4962	2	possible	possible	JJ
cord-015021-pol2qm74	4962	3	explanation	explanation	NN
cord-015021-pol2qm74	4962	4	is	be	VBZ
cord-015021-pol2qm74	4962	5	that	that	IN
cord-015021-pol2qm74	4962	6	G	G	NNP
cord-015021-pol2qm74	4962	7	-	-	HYPH
cord-015021-pol2qm74	4962	8	l	l	NN
cord-015021-pol2qm74	4962	9	-	-	HYPH
cord-015021-pol2qm74	4962	10	fueose	fueose	VBN
cord-015021-pol2qm74	4962	11	molecules	molecule	NNS
cord-015021-pol2qm74	4962	12	block	block	VBP
cord-015021-pol2qm74	4962	13	iectin	iectin	NN
cord-015021-pol2qm74	4962	14	domains	domain	NNS
cord-015021-pol2qm74	4962	15	of	of	IN
cord-015021-pol2qm74	4962	16	GNP-140	GNP-140	NNP
cord-015021-pol2qm74	4962	17	or	or	CC
cord-015021-pol2qm74	4962	18	ELAM	ELAM	NNP
cord-015021-pol2qm74	4963	1	-I	-i	WDT
cord-015021-pol2qm74	4963	2	preventing	prevent	VBG
cord-015021-pol2qm74	4963	3	the	the	DT
cord-015021-pol2qm74	4963	4	adhesion	adhesion	NN
cord-015021-pol2qm74	4963	5	of	of	IN
cord-015021-pol2qm74	4963	6	the	the	DT
cord-015021-pol2qm74	4963	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	4963	8	to	to	IN
cord-015021-pol2qm74	4963	9	the	the	DT
cord-015021-pol2qm74	4963	10	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4963	11	endotheliom	endotheliom	NN
cord-015021-pol2qm74	4963	12	.	.	.
cord-015021-pol2qm74	4964	1	Bartens	Bartens	NNP
cord-015021-pol2qm74	4964	2	C	C	NNP
cord-015021-pol2qm74	4964	3	,	,	,
cord-015021-pol2qm74	4964	4	Elmadfa	Elmadfa	NNP
cord-015021-pol2qm74	4964	5	I	-PRON-	PRP
cord-015021-pol2qm74	4964	6	,	,	,
cord-015021-pol2qm74	4964	7	Steltzer	Steltzer	NNP
cord-015021-pol2qm74	4964	8	H	H	NNP
cord-015021-pol2qm74	4964	9	,	,	,
cord-015021-pol2qm74	4964	10	Fischer	Fischer	NNP
cord-015021-pol2qm74	4964	11	M	M	NNP
cord-015021-pol2qm74	4964	12	,	,	,
cord-015021-pol2qm74	4964	13	Druml	Druml	NNP
cord-015021-pol2qm74	4964	14	W	W	NNP
cord-015021-pol2qm74	4964	15	Introduction	introduction	NN
cord-015021-pol2qm74	4964	16	:	:	:
cord-015021-pol2qm74	4964	17	Various	various	JJ
cord-015021-pol2qm74	4964	18	micronutrients	micronutrient	NNS
cord-015021-pol2qm74	4964	19	and	and	CC
cord-015021-pol2qm74	4964	20	vitamins	vitamin	NNS
cord-015021-pol2qm74	4964	21	are	be	VBP
cord-015021-pol2qm74	4964	22	particulary	particulary	RB
cord-015021-pol2qm74	4964	23	effective	effective	JJ
cord-015021-pol2qm74	4964	24	in	in	IN
cord-015021-pol2qm74	4964	25	modulating	modulate	VBG
cord-015021-pol2qm74	4964	26	immune	immune	JJ
cord-015021-pol2qm74	4964	27	functions	function	NNS
cord-015021-pol2qm74	4964	28	and	and	CC
cord-015021-pol2qm74	4964	29	host	host	NN
cord-015021-pol2qm74	4964	30	defense	defense	NN
cord-015021-pol2qm74	4964	31	.	.	.
cord-015021-pol2qm74	4965	1	The	the	DT
cord-015021-pol2qm74	4965	2	nutritive	nutritive	JJ
cord-015021-pol2qm74	4965	3	ant±oxidants	ant±oxidant	NNS
cord-015021-pol2qm74	4965	4	vitamin	vitamin	NN
cord-015021-pol2qm74	4965	5	C	c	NN
cord-015021-pol2qm74	4965	6	,	,	,
cord-015021-pol2qm74	4965	7	E	e	NN
cord-015021-pol2qm74	4965	8	and	and	CC
cord-015021-pol2qm74	4965	9	B	b	NN
cord-015021-pol2qm74	4965	10	-	-	HYPH
cord-015021-pol2qm74	4965	11	carotene	carotene	NN
cord-015021-pol2qm74	4965	12	,	,	,
cord-015021-pol2qm74	4965	13	as	as	RB
cord-015021-pol2qm74	4965	14	well	well	RB
cord-015021-pol2qm74	4965	15	as	as	IN
cord-015021-pol2qm74	4966	1	selenium	selenium	NN
cord-015021-pol2qm74	4966	2	lower	lower	RBR
cord-015021-pol2qm74	4966	3	the	the	DT
cord-015021-pol2qm74	4966	4	burden	burden	NN
cord-015021-pol2qm74	4966	5	of	of	IN
cord-015021-pol2qm74	4966	6	reactive	reactive	JJ
cord-015021-pol2qm74	4966	7	free	free	JJ
cord-015021-pol2qm74	4966	8	radicals	radical	NNS
cord-015021-pol2qm74	4966	9	and	and	CC
cord-015021-pol2qm74	4966	10	protect	protect	VB
cord-015021-pol2qm74	4966	11	the	the	DT
cord-015021-pol2qm74	4966	12	structural	structural	JJ
cord-015021-pol2qm74	4966	13	integrity	integrity	NN
cord-015021-pol2qm74	4966	14	of	of	IN
cord-015021-pol2qm74	4966	15	cells	cell	NNS
cord-015021-pol2qm74	4966	16	and	and	CC
cord-015021-pol2qm74	4966	17	tissues	tissue	NNS
cord-015021-pol2qm74	4966	18	of	of	IN
cord-015021-pol2qm74	4966	19	the	the	DT
cord-015021-pol2qm74	4966	20	immune	immune	JJ
cord-015021-pol2qm74	4966	21	system	system	NN
cord-015021-pol2qm74	4966	22	,	,	,
cord-015021-pol2qm74	4966	23	as	as	RB
cord-015021-pol2qm74	4966	24	well	well	RB
cord-015021-pol2qm74	4966	25	as	as	IN
cord-015021-pol2qm74	4966	26	other	other	JJ
cord-015021-pol2qm74	4966	27	systems	system	NNS
cord-015021-pol2qm74	4966	28	in	in	IN
cord-015021-pol2qm74	4966	29	the	the	DT
cord-015021-pol2qm74	4966	30	body	body	NN
cord-015021-pol2qm74	4966	31	.	.	.
cord-015021-pol2qm74	4967	1	Certain	certain	JJ
cord-015021-pol2qm74	4967	2	cells	cell	NNS
cord-015021-pol2qm74	4967	3	of	of	IN
cord-015021-pol2qm74	4967	4	the	the	DT
cord-015021-pol2qm74	4967	5	immune	immune	JJ
cord-015021-pol2qm74	4967	6	system	system	NN
cord-015021-pol2qm74	4967	7	like	like	IN
cord-015021-pol2qm74	4967	8	polymorphonuclear	polymorphonuclear	NNP
cord-015021-pol2qm74	4967	9	leucocytes	leucocytes	NNP
cord-015021-pol2qm74	4967	10	(	(	-LRB-
cord-015021-pol2qm74	4967	11	PMN	PMN	NNP
cord-015021-pol2qm74	4967	12	's	's	POS
cord-015021-pol2qm74	4967	13	)	)	-RRB-
cord-015021-pol2qm74	4967	14	use	use	VBP
cord-015021-pol2qm74	4967	15	free	free	JJ
cord-015021-pol2qm74	4967	16	radicals	radical	NNS
cord-015021-pol2qm74	4967	17	as	as	IN
cord-015021-pol2qm74	4967	18	a	a	DT
cord-015021-pol2qm74	4967	19	weapon	weapon	NN
cord-015021-pol2qm74	4967	20	to	to	TO
cord-015021-pol2qm74	4967	21	destroy	destroy	VB
cord-015021-pol2qm74	4967	22	invading	invade	VBG
cord-015021-pol2qm74	4967	23	pathogens	pathogen	NNS
cord-015021-pol2qm74	4967	24	.	.	.
cord-015021-pol2qm74	4968	1	These	these	DT
cord-015021-pol2qm74	4968	2	reactive	reactive	JJ
cord-015021-pol2qm74	4968	3	molecules	molecule	NNS
cord-015021-pol2qm74	4968	4	,	,	,
cord-015021-pol2qm74	4968	5	when	when	WRB
cord-015021-pol2qm74	4968	6	released	release	VBN
cord-015021-pol2qm74	4968	7	into	into	IN
cord-015021-pol2qm74	4968	8	the	the	DT
cord-015021-pol2qm74	4968	9	surrounding	surround	VBG
cord-015021-pol2qm74	4968	10	area	area	NN
cord-015021-pol2qm74	4968	11	,	,	,
cord-015021-pol2qm74	4968	12	mediate	mediate	VB
cord-015021-pol2qm74	4968	13	lipid	lipid	NN
cord-015021-pol2qm74	4968	14	peroxidation	peroxidation	NN
cord-015021-pol2qm74	4968	15	and	and	CC
cord-015021-pol2qm74	4968	16	tissue	tissue	NN
cord-015021-pol2qm74	4968	17	injury	injury	NN
cord-015021-pol2qm74	4968	18	.	.	.
cord-015021-pol2qm74	4969	1	There	there	EX
cord-015021-pol2qm74	4969	2	is	be	VBZ
cord-015021-pol2qm74	4969	3	growing	grow	VBG
cord-015021-pol2qm74	4969	4	evidence	evidence	NN
cord-015021-pol2qm74	4969	5	that	that	IN
cord-015021-pol2qm74	4969	6	PMN	PMN	NNP
cord-015021-pol2qm74	4969	7	's	's	POS
cord-015021-pol2qm74	4969	8	are	be	VBP
cord-015021-pol2qm74	4969	9	activated	activate	VBN
cord-015021-pol2qm74	4969	10	in	in	IN
cord-015021-pol2qm74	4969	11	vivo	vivo	NN
cord-015021-pol2qm74	4969	12	by	by	IN
cord-015021-pol2qm74	4969	13	complement	complement	NN
cord-015021-pol2qm74	4969	14	or	or	CC
cord-015021-pol2qm74	4969	15	immune	immune	JJ
cord-015021-pol2qm74	4969	16	complexes	complex	NNS
cord-015021-pol2qm74	4969	17	in	in	IN
cord-015021-pol2qm74	4969	18	disorders	disorder	NNS
cord-015021-pol2qm74	4969	19	such	such	JJ
cord-015021-pol2qm74	4969	20	as	as	IN
cord-015021-pol2qm74	4969	21	ARDS	ARDS	NNP
cord-015021-pol2qm74	4969	22	.	.	.
cord-015021-pol2qm74	4970	1	The	the	DT
cord-015021-pol2qm74	4970	2	respiratory	respiratory	JJ
cord-015021-pol2qm74	4970	3	host	host	NN
cord-015021-pol2qm74	4970	4	defense	defense	NN
cord-015021-pol2qm74	4970	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	4970	6	of	of	IN
cord-015021-pol2qm74	4970	7	patients	patient	NNS
cord-015021-pol2qm74	4970	8	with	with	IN
cord-015021-pol2qm74	4970	9	adult	adult	JJ
cord-015021-pol2qm74	4970	10	respiratory	respiratory	JJ
cord-015021-pol2qm74	4970	11	distress	distress	NN
cord-015021-pol2qm74	4970	12	syndrome	syndrome	NN
cord-015021-pol2qm74	4970	13	(	(	-LRB-
cord-015021-pol2qm74	4970	14	ARDS	ARDS	NNP
cord-015021-pol2qm74	4970	15	)	)	-RRB-
cord-015021-pol2qm74	4970	16	may	may	MD
cord-015021-pol2qm74	4970	17	be	be	VB
cord-015021-pol2qm74	4970	18	defective	defective	JJ
cord-015021-pol2qm74	4970	19	.	.	.
cord-015021-pol2qm74	4971	1	The	the	DT
cord-015021-pol2qm74	4971	2	aim	aim	NN
cord-015021-pol2qm74	4971	3	of	of	IN
cord-015021-pol2qm74	4971	4	this	this	DT
cord-015021-pol2qm74	4971	5	study	study	NN
cord-015021-pol2qm74	4971	6	was	be	VBD
cord-015021-pol2qm74	4971	7	ta	ta	TO
cord-015021-pol2qm74	4971	8	evaluate	evaluate	VB
cord-015021-pol2qm74	4971	9	the	the	DT
cord-015021-pol2qm74	4971	10	status	status	NN
cord-015021-pol2qm74	4971	11	of	of	IN
cord-015021-pol2qm74	4971	12	the	the	DT
cord-015021-pol2qm74	4971	13	free	free	JJ
cord-015021-pol2qm74	4971	14	radical	radical	JJ
cord-015021-pol2qm74	4971	15	scavengers	scavenger	NNS
cord-015021-pol2qm74	4971	16	and	and	CC
cord-015021-pol2qm74	4971	17	their	-PRON-	PRP$
cord-015021-pol2qm74	4971	18	activity	activity	NN
cord-015021-pol2qm74	4971	19	in	in	IN
cord-015021-pol2qm74	4971	20	ARDS	ARDS	NNP
cord-015021-pol2qm74	4971	21	and	and	CC
cord-015021-pol2qm74	4971	22	to	to	TO
cord-015021-pol2qm74	4971	23	investigate	investigate	VB
cord-015021-pol2qm74	4971	24	the	the	DT
cord-015021-pol2qm74	4971	25	respiratory	respiratory	JJ
cord-015021-pol2qm74	4971	26	burst	burst	NN
cord-015021-pol2qm74	4971	27	of	of	IN
cord-015021-pol2qm74	4971	28	ARDS	ARDS	NNP
cord-015021-pol2qm74	4971	29	patients	patient	NNS
cord-015021-pol2qm74	4971	30	.	.	.
cord-015021-pol2qm74	4972	1	Methods	method	NNS
cord-015021-pol2qm74	4972	2	:	:	:
cord-015021-pol2qm74	4972	3	Seven	seven	CD
cord-015021-pol2qm74	4972	4	ARDS	ARDS	NNP
cord-015021-pol2qm74	4972	5	patients	patient	NNS
cord-015021-pol2qm74	4972	6	(	(	-LRB-
cord-015021-pol2qm74	4972	7	3	3	CD
cord-015021-pol2qm74	4972	8	sepsis	sepsis	NN
cord-015021-pol2qm74	4972	9	,	,	,
cord-015021-pol2qm74	4972	10	4	4	CD
cord-015021-pol2qm74	4972	11	trauma	trauma	NN
cord-015021-pol2qm74	4972	12	)	)	-RRB-
cord-015021-pol2qm74	4972	13	with	with	IN
cord-015021-pol2qm74	4972	14	an	an	DT
cord-015021-pol2qm74	4972	15	Fie	Fie	NNP
cord-015021-pol2qm74	4972	16	2	2	CD
cord-015021-pol2qm74	4972	17	of	of	IN
cord-015021-pol2qm74	4972	18	0.59	0.59	CD
cord-015021-pol2qm74	4972	19	+	+	SYM
cord-015021-pol2qm74	4972	20	0.(36	0.(36	CD
cord-015021-pol2qm74	4972	21	,	,	,
cord-015021-pol2qm74	4972	22	a	a	DT
cord-015021-pol2qm74	4972	23	PEEP	peep	NN
cord-015021-pol2qm74	4972	24	of	of	IN
cord-015021-pol2qm74	4972	25	8.50±0.99	8.50±0.99	CD
cord-015021-pol2qm74	4972	26	,	,	,
cord-015021-pol2qm74	4972	27	and	and	CC
cord-015021-pol2qm74	4972	28	a	a	DT
cord-015021-pol2qm74	4972	29	Murray	Murray	NNP
cord-015021-pol2qm74	4972	30	score	score	NN
cord-015021-pol2qm74	4972	31	of	of	IN
cord-015021-pol2qm74	4972	32	2.83	2.83	CD
cord-015021-pol2qm74	4972	33	±0.18	±0.18	NNS
cord-015021-pol2qm74	4972	34	were	be	VBD
cord-015021-pol2qm74	4972	35	included	include	VBN
cord-015021-pol2qm74	4972	36	in	in	IN
cord-015021-pol2qm74	4972	37	this	this	DT
cord-015021-pol2qm74	4972	38	study	study	NN
cord-015021-pol2qm74	4972	39	.	.	.
cord-015021-pol2qm74	4973	1	15	15	CD
cord-015021-pol2qm74	4973	2	healthy	healthy	JJ
cord-015021-pol2qm74	4973	3	adults	adult	NNS
cord-015021-pol2qm74	4973	4	served	serve	VBD
cord-015021-pol2qm74	4973	5	as	as	IN
cord-015021-pol2qm74	4973	6	controls	control	NNS
cord-015021-pol2qm74	4973	7	.	.	.
cord-015021-pol2qm74	4974	1	Superoxide	superoxide	NN
cord-015021-pol2qm74	4974	2	anion	anion	NN
cord-015021-pol2qm74	4974	3	production	production	NN
cord-015021-pol2qm74	4974	4	in	in	IN
cord-015021-pol2qm74	4974	5	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	4974	6	was	be	VBD
cord-015021-pol2qm74	4974	7	measured	measure	VBN
cord-015021-pol2qm74	4974	8	photometrically	photometrically	RB
cord-015021-pol2qm74	4974	9	,	,	,
cord-015021-pol2qm74	4974	10	and	and	CC
cord-015021-pol2qm74	4974	11	the	the	DT
cord-015021-pol2qm74	4974	12	hydrogen	hydrogen	NN
cord-015021-pol2qm74	4974	13	peroxides	peroxide	NNS
cord-015021-pol2qm74	4974	14	by	by	IN
cord-015021-pol2qm74	4974	15	fluorimetric	fluorimetric	JJ
cord-015021-pol2qm74	4974	16	assay	assay	NN
cord-015021-pol2qm74	4974	17	.	.	.
cord-015021-pol2qm74	4975	1	Vitamin	vitamin	NN
cord-015021-pol2qm74	4975	2	A	a	NN
cord-015021-pol2qm74	4975	3	,	,	,
cord-015021-pol2qm74	4975	4	E	e	NN
cord-015021-pol2qm74	4975	5	,	,	,
cord-015021-pol2qm74	4975	6	and	and	CC
cord-015021-pol2qm74	4975	7	g	g	NN
cord-015021-pol2qm74	4975	8	-	-	HYPH
cord-015021-pol2qm74	4975	9	carotene	carotene	NN
cord-015021-pol2qm74	4975	10	concentrations	concentration	NNS
cord-015021-pol2qm74	4975	11	were	be	VBD
cord-015021-pol2qm74	4975	12	assessed	assess	VBN
cord-015021-pol2qm74	4975	13	by	by	IN
cord-015021-pol2qm74	4975	14	HPLC	HPLC	NNP
cord-015021-pol2qm74	4975	15	,	,	,
cord-015021-pol2qm74	4975	16	and	and	CC
cord-015021-pol2qm74	4975	17	plasma	plasma	NN
cord-015021-pol2qm74	4975	18	vitamin	vitamin	NN
cord-015021-pol2qm74	4975	19	C	c	NN
cord-015021-pol2qm74	4975	20	photometrically	photometrically	RB
cord-015021-pol2qm74	4975	21	.	.	.
cord-015021-pol2qm74	4976	1	Plasma	plasma	NN
cord-015021-pol2qm74	4976	2	selenium	selenium	NN
cord-015021-pol2qm74	4976	3	was	be	VBD
cord-015021-pol2qm74	4976	4	determined	determine	VBN
cord-015021-pol2qm74	4976	5	by	by	IN
cord-015021-pol2qm74	4976	6	dectrothermal	dectrothermal	JJ
cord-015021-pol2qm74	4976	7	AAS	AAS	NNP
cord-015021-pol2qm74	4976	8	.	.	.
cord-015021-pol2qm74	4977	1	Plasma	plasma	NN
cord-015021-pol2qm74	4977	2	lipid	lipid	NN
cord-015021-pol2qm74	4977	3	peroxidation	peroxidation	NN
cord-015021-pol2qm74	4977	4	pruducts	pruduct	NNS
cord-015021-pol2qm74	4977	5	,	,	,
cord-015021-pol2qm74	4977	6	expressed	express	VBD
cord-015021-pol2qm74	4977	7	as	as	IN
cord-015021-pol2qm74	4977	8	malondialdehyde	malondialdehyde	NNP
cord-015021-pol2qm74	4977	9	(	(	-LRB-
cord-015021-pol2qm74	4977	10	MDA	MDA	NNP
cord-015021-pol2qm74	4977	11	)	)	-RRB-
cord-015021-pol2qm74	4977	12	,	,	,
cord-015021-pol2qm74	4977	13	were	be	VBD
cord-015021-pol2qm74	4977	14	determined	determine	VBN
cord-015021-pol2qm74	4977	15	by	by	IN
cord-015021-pol2qm74	4977	16	thiobarbituric	thiobarbituric	JJ
cord-015021-pol2qm74	4977	17	acid	acid	NN
cord-015021-pol2qm74	4977	18	assay	assay	NN
cord-015021-pol2qm74	4977	19	and	and	CC
cord-015021-pol2qm74	4977	20	HPLC	HPLC	NNP
cord-015021-pol2qm74	4977	21	.	.	.
cord-015021-pol2qm74	4978	1	Results	result	NNS
cord-015021-pol2qm74	4978	2	:	:	:
cord-015021-pol2qm74	4978	3	MDA	MDA	NNP
cord-015021-pol2qm74	4978	4	-	-	HYPH
cord-015021-pol2qm74	4978	5	plasma	plasma	NN
cord-015021-pol2qm74	4978	6	(	(	-LRB-
cord-015021-pol2qm74	4978	7	/xmol	/xmol	NNP
cord-015021-pol2qm74	4978	8	/	/	SYM
cord-015021-pol2qm74	4978	9	l	l	NN
cord-015021-pol2qm74	4978	10	)	)	-RRB-
cord-015021-pol2qm74	4978	11	0.74~	0.74~	CD
cord-015021-pol2qm74	4978	12	:	:	:
cord-015021-pol2qm74	4979	1	0.46	0.46	CD
cord-015021-pol2qm74	4980	1	*	*	NFP
cord-015021-pol2qm74	4980	2	0.37	0.37	CD
cord-015021-pol2qm74	4980	3	±	±	CD
cord-015021-pol2qm74	4980	4	0.16	0.16	CD
cord-015021-pol2qm74	4981	1	*	*	NFP
cord-015021-pol2qm74	4981	2	=	=	NFP
cord-015021-pol2qm74	4981	3	<	<	XX
cord-015021-pol2qm74	4981	4	0.01	0.01	CD
cord-015021-pol2qm74	4981	5	,	,	,
cord-015021-pol2qm74	4982	1	*	*	NFP
cord-015021-pol2qm74	4982	2	*	*	NFP
cord-015021-pol2qm74	4982	3	=	=	SYM
cord-015021-pol2qm74	4982	4	p<0.001	p<0.001	JJ
cord-015021-pol2qm74	4982	5	Condusion	Condusion	NNP
cord-015021-pol2qm74	4982	6	:	:	:
cord-015021-pol2qm74	4983	1	ARDS	ARDS	NNP
cord-015021-pol2qm74	4983	2	patients	patient	NNS
cord-015021-pol2qm74	4983	3	showed	show	VBD
cord-015021-pol2qm74	4983	4	significantly	significantly	RB
cord-015021-pol2qm74	4983	5	decreased	decrease	VBD
cord-015021-pol2qm74	4983	6	plasma	plasma	NN
cord-015021-pol2qm74	4983	7	concentrations	concentration	NNS
cord-015021-pol2qm74	4983	8	of	of	IN
cord-015021-pol2qm74	4983	9	vitamin	vitamin	NN
cord-015021-pol2qm74	4983	10	C	c	NN
cord-015021-pol2qm74	4983	11	,	,	,
cord-015021-pol2qm74	4983	12	E	e	NN
cord-015021-pol2qm74	4983	13	and	and	CC
cord-015021-pol2qm74	4983	14	g	g	NN
cord-015021-pol2qm74	4983	15	-	-	HYPH
cord-015021-pol2qm74	4983	16	carotene	carotene	NN
cord-015021-pol2qm74	4983	17	,	,	,
cord-015021-pol2qm74	4983	18	as	as	RB
cord-015021-pol2qm74	4983	19	well	well	RB
cord-015021-pol2qm74	4983	20	as	as	IN
cord-015021-pol2qm74	4983	21	selenium	selenium	NN
cord-015021-pol2qm74	4983	22	.	.	.
cord-015021-pol2qm74	4984	1	These	these	DT
cord-015021-pol2qm74	4984	2	nutritive	nutritive	JJ
cord-015021-pol2qm74	4984	3	ant±oxidants	ant±oxidant	NNS
cord-015021-pol2qm74	4984	4	are	be	VBP
cord-015021-pol2qm74	4984	5	consumed	consume	VBN
cord-015021-pol2qm74	4984	6	during	during	IN
cord-015021-pol2qm74	4984	7	increased	increase	VBN
cord-015021-pol2qm74	4984	8	oxidative	oxidative	JJ
cord-015021-pol2qm74	4984	9	stress	stress	NN
cord-015021-pol2qm74	4984	10	.	.	.
cord-015021-pol2qm74	4985	1	MDA	MDA	NNP
cord-015021-pol2qm74	4985	2	,	,	,
cord-015021-pol2qm74	4985	3	a	a	DT
cord-015021-pol2qm74	4985	4	final	final	JJ
cord-015021-pol2qm74	4985	5	product	product	NN
cord-015021-pol2qm74	4985	6	of	of	IN
cord-015021-pol2qm74	4985	7	lipid	lipid	NN
cord-015021-pol2qm74	4985	8	peroxidation	peroxidation	NN
cord-015021-pol2qm74	4985	9	,	,	,
cord-015021-pol2qm74	4985	10	is	be	VBZ
cord-015021-pol2qm74	4985	11	increased	increase	VBN
cord-015021-pol2qm74	4985	12	.	.	.
cord-015021-pol2qm74	4986	1	However	however	RB
cord-015021-pol2qm74	4986	2	,	,	,
cord-015021-pol2qm74	4986	3	a	a	DT
cord-015021-pol2qm74	4986	4	difference	difference	NN
cord-015021-pol2qm74	4986	5	in	in	IN
cord-015021-pol2qm74	4986	6	rates	rate	NNS
cord-015021-pol2qm74	4986	7	of	of	IN
cord-015021-pol2qm74	4986	8	release	release	NN
cord-015021-pol2qm74	4986	9	of	of	IN
cord-015021-pol2qm74	4986	10	hydrogen	hydrogen	NN
cord-015021-pol2qm74	4986	11	peroxides	peroxide	NNS
cord-015021-pol2qm74	4986	12	and	and	CC
cord-015021-pol2qm74	4986	13	superoxide	superoxide	NN
cord-015021-pol2qm74	4986	14	-	-	HYPH
cord-015021-pol2qm74	4986	15	anion	anion	NN
cord-015021-pol2qm74	4986	16	of	of	IN
cord-015021-pol2qm74	4986	17	PMN	PMN	NNP
cord-015021-pol2qm74	4986	18	could	could	MD
cord-015021-pol2qm74	4986	19	not	not	RB
cord-015021-pol2qm74	4986	20	be	be	VB
cord-015021-pol2qm74	4986	21	detected	detect	VBN
cord-015021-pol2qm74	4986	22	.	.	.
cord-015021-pol2qm74	4987	1	Therefore	therefore	RB
cord-015021-pol2qm74	4987	2	,	,	,
cord-015021-pol2qm74	4987	3	oxygen	oxygen	NN
cord-015021-pol2qm74	4987	4	radical	radical	JJ
cord-015021-pol2qm74	4987	5	accumulation	accumulation	NN
cord-015021-pol2qm74	4987	6	is	be	VBZ
cord-015021-pol2qm74	4987	7	more	more	RBR
cord-015021-pol2qm74	4987	8	likely	likely	RB
cord-015021-pol2qm74	4987	9	a	a	DT
cord-015021-pol2qm74	4987	10	result	result	NN
cord-015021-pol2qm74	4987	11	of	of	IN
cord-015021-pol2qm74	4987	12	excessive	excessive	JJ
cord-015021-pol2qm74	4987	13	inspiratory	inspiratory	JJ
cord-015021-pol2qm74	4987	14	oxygen	oxygen	NN
cord-015021-pol2qm74	4987	15	concentrations	concentration	NNS
cord-015021-pol2qm74	4987	16	(	(	-LRB-
cord-015021-pol2qm74	4987	17	F.iO2	F.iO2	NNP
cord-015021-pol2qm74	4987	18	)	)	-RRB-
cord-015021-pol2qm74	4987	19	,	,	,
cord-015021-pol2qm74	4987	20	pro	pro	JJ
cord-015021-pol2qm74	4987	21	-	-	JJ
cord-015021-pol2qm74	4987	22	oxidant	oxidant	JJ
cord-015021-pol2qm74	4987	23	drugs	drug	NNS
cord-015021-pol2qm74	4987	24	,	,	,
cord-015021-pol2qm74	4987	25	and	and	CC
cord-015021-pol2qm74	4987	26	a	a	DT
cord-015021-pol2qm74	4987	27	high	high	JJ
cord-015021-pol2qm74	4987	28	settlement	settlement	NN
cord-015021-pol2qm74	4987	29	of	of	IN
cord-015021-pol2qm74	4987	30	PMN	PMN	NNP
cord-015021-pol2qm74	4987	31	in	in	IN
cord-015021-pol2qm74	4987	32	the	the	DT
cord-015021-pol2qm74	4987	33	lungs	lung	NNS
cord-015021-pol2qm74	4987	34	,	,	,
cord-015021-pol2qm74	4987	35	and	and	CC
cord-015021-pol2qm74	4987	36	not	not	RB
cord-015021-pol2qm74	4987	37	an	an	DT
cord-015021-pol2qm74	4987	38	increased	increase	VBN
cord-015021-pol2qm74	4987	39	release	release	NN
cord-015021-pol2qm74	4987	40	of	of	IN
cord-015021-pol2qm74	4987	41	free	free	JJ
cord-015021-pol2qm74	4987	42	radicals	radical	NNS
cord-015021-pol2qm74	4987	43	of	of	IN
cord-015021-pol2qm74	4987	44	the	the	DT
cord-015021-pol2qm74	4987	45	single	single	JJ
cord-015021-pol2qm74	4987	46	PMN	PMN	NNP
cord-015021-pol2qm74	4987	47	.	.	.
cord-015021-pol2qm74	4988	1	kD	kD	NNP
cord-015021-pol2qm74	4988	2	glycoprotein	glycoprotein	NN
cord-015021-pol2qm74	4988	3	secreted	secrete	VBN
cord-015021-pol2qm74	4988	4	by	by	IN
cord-015021-pol2qm74	4988	5	the	the	DT
cord-015021-pol2qm74	4988	6	alveolar	alveolar	NN
cord-015021-pol2qm74	4988	7	type	type	NN
cord-015021-pol2qm74	4988	8	II	ii	CD
cord-015021-pol2qm74	4988	9	cells	cell	NNS
cord-015021-pol2qm74	4988	10	.	.	.
cord-015021-pol2qm74	4989	1	Recent	recent	JJ
cord-015021-pol2qm74	4989	2	study	study	NN
cord-015021-pol2qm74	4989	3	showed	show	VBD
cord-015021-pol2qm74	4989	4	that	that	IN
cord-015021-pol2qm74	4989	5	SP	SP	NNP
cord-015021-pol2qm74	4989	6	-	-	HYPH
cord-015021-pol2qm74	4989	7	A	A	NNP
cord-015021-pol2qm74	4989	8	exists	exist	VBZ
cord-015021-pol2qm74	4989	9	in	in	IN
cord-015021-pol2qm74	4989	10	the	the	DT
cord-015021-pol2qm74	4989	11	sera	sera	NNP
cord-015021-pol2qm74	4989	12	from	from	IN
cord-015021-pol2qm74	4989	13	normal	normal	JJ
cord-015021-pol2qm74	4989	14	healthy	healthy	JJ
cord-015021-pol2qm74	4989	15	adults	adult	NNS
cord-015021-pol2qm74	4989	16	and	and	CC
cord-015021-pol2qm74	4989	17	that	that	IN
cord-015021-pol2qm74	4989	18	the	the	DT
cord-015021-pol2qm74	4989	19	significantly	significantly	RB
cord-015021-pol2qm74	4989	20	elevated	elevated	JJ
cord-015021-pol2qm74	4989	21	serum	serum	NN
cord-015021-pol2qm74	4989	22	SP	sp	NN
cord-015021-pol2qm74	4989	23	-	-	HYPH
cord-015021-pol2qm74	4989	24	A	A	NNP
cord-015021-pol2qm74	4989	25	levels	level	NNS
cord-015021-pol2qm74	4989	26	were	be	VBD
cord-015021-pol2qm74	4989	27	observed	observe	VBN
cord-015021-pol2qm74	4989	28	in	in	IN
cord-015021-pol2qm74	4989	29	the	the	DT
cord-015021-pol2qm74	4989	30	patients	patient	NNS
cord-015021-pol2qm74	4989	31	with	with	IN
cord-015021-pol2qm74	4989	32	interstitial	interstitial	JJ
cord-015021-pol2qm74	4989	33	pneumonia	pneumonia	NN
cord-015021-pol2qm74	4989	34	and	and	CC
cord-015021-pol2qm74	4989	35	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	4989	36	alveolar	alveolar	NN
cord-015021-pol2qm74	4989	37	proteinosis	proteinosis	NN
cord-015021-pol2qm74	4989	38	.	.	.
cord-015021-pol2qm74	4990	1	These	these	DT
cord-015021-pol2qm74	4990	2	findings	finding	NNS
cord-015021-pol2qm74	4990	3	means	mean	VBZ
cord-015021-pol2qm74	4990	4	there	there	EX
cord-015021-pol2qm74	4990	5	may	may	MD
cord-015021-pol2qm74	4990	6	be	be	VB
cord-015021-pol2qm74	4990	7	a	a	DT
cord-015021-pol2qm74	4990	8	mechanism	mechanism	NN
cord-015021-pol2qm74	4990	9	that	that	WDT
cord-015021-pol2qm74	4990	10	the	the	DT
cord-015021-pol2qm74	4990	11	SP	SP	NNP
cord-015021-pol2qm74	4990	12	-	-	HYPH
cord-015021-pol2qm74	4990	13	A	A	NNP
cord-015021-pol2qm74	4990	14	produced	produce	VBN
cord-015021-pol2qm74	4990	15	in	in	IN
cord-015021-pol2qm74	4990	16	the	the	DT
cord-015021-pol2qm74	4990	17	alveoli	alveoli	NN
cord-015021-pol2qm74	4990	18	escapes	escape	VBZ
cord-015021-pol2qm74	4990	19	into	into	IN
cord-015021-pol2qm74	4990	20	the	the	DT
cord-015021-pol2qm74	4990	21	bloodstream	bloodstream	NN
cord-015021-pol2qm74	4990	22	.	.	.
cord-015021-pol2qm74	4991	1	Here	here	RB
cord-015021-pol2qm74	4991	2	we	-PRON-	PRP
cord-015021-pol2qm74	4991	3	examined	examine	VBD
cord-015021-pol2qm74	4991	4	the	the	DT
cord-015021-pol2qm74	4991	5	serum	serum	NN
cord-015021-pol2qm74	4991	6	SP	sp	NN
cord-015021-pol2qm74	4991	7	-	-	HYPH
cord-015021-pol2qm74	4991	8	A	A	NNP
cord-015021-pol2qm74	4991	9	levels	level	NNS
cord-015021-pol2qm74	4991	10	in	in	IN
cord-015021-pol2qm74	4991	11	the	the	DT
cord-015021-pol2qm74	4991	12	patients	patient	NNS
cord-015021-pol2qm74	4991	13	with	with	IN
cord-015021-pol2qm74	4991	14	critical	critical	JJ
cord-015021-pol2qm74	4991	15	illness	illness	NN
cord-015021-pol2qm74	4991	16	including	include	VBG
cord-015021-pol2qm74	4991	17	sepsis	sepsis	NN
cord-015021-pol2qm74	4991	18	and	and	CC
cord-015021-pol2qm74	4991	19	ARDS	ARDS	NNP
cord-015021-pol2qm74	4991	20	.	.	.
cord-015021-pol2qm74	4991	21	]	]	-RRB-
cord-015021-pol2qm74	4992	1	Clinical	clinical	JJ
cord-015021-pol2qm74	4992	2	Subjects	subject	NNS
cord-015021-pol2qm74	4992	3	&	&	CC
cord-015021-pol2qm74	4992	4	Methods	Methods	NNPS
cord-015021-pol2qm74	4992	5	]	]	-RRB-
cord-015021-pol2qm74	4993	1	A	a	DT
cord-015021-pol2qm74	4993	2	total	total	NN
cord-015021-pol2qm74	4993	3	of	of	IN
cord-015021-pol2qm74	4993	4	99	99	CD
cord-015021-pol2qm74	4993	5	serum	serum	NN
cord-015021-pol2qm74	4993	6	samples	sample	NNS
cord-015021-pol2qm74	4993	7	were	be	VBD
cord-015021-pol2qm74	4993	8	collected	collect	VBN
cord-015021-pol2qm74	4993	9	from	from	IN
cord-015021-pol2qm74	4993	10	39	39	CD
cord-015021-pol2qm74	4993	11	patients	patient	NNS
cord-015021-pol2qm74	4993	12	hospitalized	hospitalize	VBN
cord-015021-pol2qm74	4993	13	in	in	IN
cord-015021-pol2qm74	4993	14	the	the	DT
cord-015021-pol2qm74	4993	15	Division	Division	NNP
cord-015021-pol2qm74	4993	16	of	of	IN
cord-015021-pol2qm74	4993	17	Critical	Critical	NNP
cord-015021-pol2qm74	4993	18	Care	Care	NNP
cord-015021-pol2qm74	4993	19	Medicine(ICU	Medicine(ICU	NNP
cord-015021-pol2qm74	4993	20	)	)	-RRB-
cord-015021-pol2qm74	4993	21	,	,	,
cord-015021-pol2qm74	4993	22	Sappom	Sappom	NNP
cord-015021-pol2qm74	4993	23	Medical	Medical	NNP
cord-015021-pol2qm74	4993	24	College	College	NNP
cord-015021-pol2qm74	4993	25	Hospital	Hospital	NNP
cord-015021-pol2qm74	4993	26	.	.	.
cord-015021-pol2qm74	4994	1	Serum	serum	NN
cord-015021-pol2qm74	4994	2	SP	sp	NN
cord-015021-pol2qm74	4994	3	-	-	HYPH
cord-015021-pol2qm74	4994	4	A	A	NNP
cord-015021-pol2qm74	4994	5	levels	level	NNS
cord-015021-pol2qm74	4994	6	were	be	VBD
cord-015021-pol2qm74	4994	7	measured	measure	VBN
cord-015021-pol2qm74	4994	8	by	by	IN
cord-015021-pol2qm74	4994	9	an	an	DT
cord-015021-pol2qm74	4994	10	enzyme	enzyme	NN
cord-015021-pol2qm74	4994	11	-	-	HYPH
cord-015021-pol2qm74	4994	12	linked	link	VBN
cord-015021-pol2qm74	4994	13	immunosorbent	immunosorbent	JJ
cord-015021-pol2qm74	4994	14	assay	assay	NN
cord-015021-pol2qm74	4994	15	using	use	VBG
cord-015021-pol2qm74	4994	16	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	4994	17	antibodies	antibody	NNS
cord-015021-pol2qm74	4994	18	to	to	IN
cord-015021-pol2qm74	4994	19	human	human	JJ
cord-015021-pol2qm74	4994	20	SP	sp	NN
cord-015021-pol2qm74	4994	21	-	-	HYPH
cord-015021-pol2qm74	4994	22	A.	a.	NN
cord-015021-pol2qm74	4994	23	]	]	-RRB-
cord-015021-pol2qm74	4994	24	Results	result	NNS
cord-015021-pol2qm74	4994	25	]	]	-RRB-
cord-015021-pol2qm74	4995	1	There	there	EX
cord-015021-pol2qm74	4995	2	was	be	VBD
cord-015021-pol2qm74	4995	3	no	no	DT
cord-015021-pol2qm74	4995	4	significant	significant	JJ
cord-015021-pol2qm74	4995	5	difference	difference	NN
cord-015021-pol2qm74	4995	6	between	between	IN
cord-015021-pol2qm74	4995	7	the	the	DT
cord-015021-pol2qm74	4995	8	septic	septic	NN
cord-015021-pol2qm74	4995	9	(	(	-LRB-
cord-015021-pol2qm74	4995	10	n=12	n=12	NNP
cord-015021-pol2qm74	4995	11	)	)	-RRB-
cord-015021-pol2qm74	4995	12	and	and	CC
cord-015021-pol2qm74	4995	13	non	non	JJ
cord-015021-pol2qm74	4995	14	-	-	JJ
cord-015021-pol2qm74	4995	15	septic	septic	JJ
cord-015021-pol2qm74	4995	16	(	(	-LRB-
cord-015021-pol2qm74	4995	17	n=27	n=27	NNP
cord-015021-pol2qm74	4995	18	)	)	-RRB-
cord-015021-pol2qm74	4995	19	patients	patient	NNS
cord-015021-pol2qm74	4995	20	.	.	.
cord-015021-pol2qm74	4996	1	Patients	patient	NNS
cord-015021-pol2qm74	4996	2	with	with	IN
cord-015021-pol2qm74	4996	3	ARDS	ARDS	NNP
cord-015021-pol2qm74	4996	4	(	(	-LRB-
cord-015021-pol2qm74	4996	5	n=10	n=10	NNP
cord-015021-pol2qm74	4996	6	,	,	,
cord-015021-pol2qm74	4996	7	52.0	52.0	CD
cord-015021-pol2qm74	4996	8	+	+	SYM
cord-015021-pol2qm74	4996	9	4.85ng	4.85ng	CD
cord-015021-pol2qm74	4996	10	/	/	SYM
cord-015021-pol2qm74	4996	11	ml	ml	NN
cord-015021-pol2qm74	4996	12	)	)	-RRB-
cord-015021-pol2qm74	4996	13	and	and	CC
cord-015021-pol2qm74	4996	14	with	with	IN
cord-015021-pol2qm74	4996	15	respiratory	respiratory	JJ
cord-015021-pol2qm74	4996	16	disease	disease	NN
cord-015021-pol2qm74	4996	17	other	other	JJ
cord-015021-pol2qm74	4996	18	than	than	IN
cord-015021-pol2qm74	4996	19	ARDS	ARDS	NNP
cord-015021-pol2qm74	4996	20	(	(	-LRB-
cord-015021-pol2qm74	4997	1	n=12	n=12	NNP
cord-015021-pol2qm74	4997	2	,	,	,
cord-015021-pol2qm74	4997	3	49.6	49.6	CD
cord-015021-pol2qm74	4997	4	+	+	CC
cord-015021-pol2qm74	4997	5	-5.35ng	-5.35ng	NN
cord-015021-pol2qm74	4997	6	/	/	SYM
cord-015021-pol2qm74	4997	7	ml	ml	NN
cord-015021-pol2qm74	4997	8	)	)	-RRB-
cord-015021-pol2qm74	4997	9	showed	show	VBD
cord-015021-pol2qm74	4997	10	significantly	significantly	RB
cord-015021-pol2qm74	4997	11	higher	high	JJR
cord-015021-pol2qm74	4997	12	levels	level	NNS
cord-015021-pol2qm74	4997	13	of	of	IN
cord-015021-pol2qm74	4997	14	serum	serum	NN
cord-015021-pol2qm74	4997	15	SP	sp	NN
cord-015021-pol2qm74	4997	16	-	-	HYPH
cord-015021-pol2qm74	4997	17	A	a	NN
cord-015021-pol2qm74	4997	18	than	than	IN
cord-015021-pol2qm74	4997	19	those	those	DT
cord-015021-pol2qm74	4997	20	with	with	IN
cord-015021-pol2qm74	4997	21	non	non	JJ
cord-015021-pol2qm74	4997	22	-	-	JJ
cord-015021-pol2qm74	4997	23	respiratory	respiratory	JJ
cord-015021-pol2qm74	4997	24	disease	disease	NN
cord-015021-pol2qm74	4997	25	(	(	-LRB-
cord-015021-pol2qm74	4997	26	n=17	n=17	NNP
cord-015021-pol2qm74	4997	27	,	,	,
cord-015021-pol2qm74	4997	28	27.4_+4.86ng	27.4_+4.86ng	CD
cord-015021-pol2qm74	4997	29	/	/	SYM
cord-015021-pol2qm74	4997	30	ml	ml	NN
cord-015021-pol2qm74	4997	31	)	)	-RRB-
cord-015021-pol2qm74	4997	32	.	.	.
cord-015021-pol2qm74	4998	1	As	as	IN
cord-015021-pol2qm74	4998	2	to	to	IN
cord-015021-pol2qm74	4998	3	the	the	DT
cord-015021-pol2qm74	4998	4	ARDS	ARDS	NNP
cord-015021-pol2qm74	4998	5	patients	patient	NNS
cord-015021-pol2qm74	4998	6	,	,	,
cord-015021-pol2qm74	4998	7	it	-PRON-	PRP
cord-015021-pol2qm74	4998	8	was	be	VBD
cord-015021-pol2qm74	4998	9	likely	likely	JJ
cord-015021-pol2qm74	4998	10	that	that	IN
cord-015021-pol2qm74	4998	11	the	the	DT
cord-015021-pol2qm74	4998	12	serum	serum	NN
cord-015021-pol2qm74	4998	13	SP	sp	NN
cord-015021-pol2qm74	4998	14	-	-	HYPH
cord-015021-pol2qm74	4998	15	A	A	NNP
cord-015021-pol2qm74	4998	16	levels	level	NNS
cord-015021-pol2qm74	4998	17	were	be	VBD
cord-015021-pol2qm74	4998	18	getting	get	VBG
cord-015021-pol2qm74	4998	19	higher	high	JJR
cord-015021-pol2qm74	4998	20	in	in	IN
cord-015021-pol2qm74	4998	21	their	-PRON-	PRP$
cord-015021-pol2qm74	4998	22	clinical	clinical	JJ
cord-015021-pol2qm74	4998	23	courses	course	NNS
cord-015021-pol2qm74	4998	24	.	.	.
cord-015021-pol2qm74	4999	1	However	however	RB
cord-015021-pol2qm74	4999	2	,	,	,
cord-015021-pol2qm74	4999	3	there	there	EX
cord-015021-pol2qm74	4999	4	was	be	VBD
cord-015021-pol2qm74	4999	5	no	no	DT
cord-015021-pol2qm74	4999	6	significant	significant	JJ
cord-015021-pol2qm74	4999	7	correlation	correlation	NN
cord-015021-pol2qm74	4999	8	between	between	IN
cord-015021-pol2qm74	4999	9	the	the	DT
cord-015021-pol2qm74	4999	10	serum	serum	NN
cord-015021-pol2qm74	4999	11	SP	sp	NN
cord-015021-pol2qm74	4999	12	-	-	HYPH
cord-015021-pol2qm74	4999	13	A	A	NNP
cord-015021-pol2qm74	4999	14	levels	level	NNS
cord-015021-pol2qm74	4999	15	and	and	CC
cord-015021-pol2qm74	4999	16	the	the	DT
cord-015021-pol2qm74	4999	17	Pa%/FiO	Pa%/FiO	NNS
cord-015021-pol2qm74	4999	18	2	2	CD
cord-015021-pol2qm74	4999	19	ratio	ratio	NN
cord-015021-pol2qm74	4999	20	.	.	.
cord-015021-pol2qm74	4999	21	]	]	-RRB-
cord-015021-pol2qm74	5000	1	Discussion	discussion	NN
cord-015021-pol2qm74	5000	2	]	]	-RRB-
cord-015021-pol2qm74	5001	1	At	at	IN
cord-015021-pol2qm74	5001	2	the	the	DT
cord-015021-pol2qm74	5001	3	present	present	JJ
cord-015021-pol2qm74	5001	4	time	time	NN
cord-015021-pol2qm74	5001	5	,	,	,
cord-015021-pol2qm74	5001	6	the	the	DT
cord-015021-pol2qm74	5001	7	exact	exact	JJ
cord-015021-pol2qm74	5001	8	mechanism	mechanism	NN
cord-015021-pol2qm74	5001	9	of	of	IN
cord-015021-pol2qm74	5001	10	the	the	DT
cord-015021-pol2qm74	5001	11	escape	escape	NN
cord-015021-pol2qm74	5001	12	of	of	IN
cord-015021-pol2qm74	5001	13	SP	SP	NNP
cord-015021-pol2qm74	5001	14	-	-	HYPH
cord-015021-pol2qm74	5001	15	A	a	NN
cord-015021-pol2qm74	5001	16	into	into	IN
cord-015021-pol2qm74	5001	17	the	the	DT
cord-015021-pol2qm74	5001	18	bloodstream	bloodstream	NN
cord-015021-pol2qm74	5001	19	remain	remain	VBP
cord-015021-pol2qm74	5001	20	to	to	TO
cord-015021-pol2qm74	5001	21	be	be	VB
cord-015021-pol2qm74	5001	22	unclear	unclear	JJ
cord-015021-pol2qm74	5001	23	.	.	.
cord-015021-pol2qm74	5002	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	5002	2	results	result	NNS
cord-015021-pol2qm74	5002	3	may	may	MD
cord-015021-pol2qm74	5002	4	suggested	suggest	VBD
cord-015021-pol2qm74	5002	5	that	that	IN
cord-015021-pol2qm74	5002	6	there	there	EX
cord-015021-pol2qm74	5002	7	was	be	VBD
cord-015021-pol2qm74	5002	8	some	some	DT
cord-015021-pol2qm74	5002	9	relation	relation	NN
cord-015021-pol2qm74	5002	10	between	between	IN
cord-015021-pol2qm74	5002	11	this	this	DT
cord-015021-pol2qm74	5002	12	leakage	leakage	NN
cord-015021-pol2qm74	5002	13	of	of	IN
cord-015021-pol2qm74	5002	14	SP	SP	NNP
cord-015021-pol2qm74	5002	15	-	-	HYPH
cord-015021-pol2qm74	5002	16	A	A	NNP
cord-015021-pol2qm74	5002	17	and	and	CC
cord-015021-pol2qm74	5002	18	the	the	DT
cord-015021-pol2qm74	5002	19	alveolar	alveolar	NN
cord-015021-pol2qm74	5002	20	-	-	HYPH
cord-015021-pol2qm74	5002	21	capillary	capillary	JJ
cord-015021-pol2qm74	5002	22	permeability	permeability	NN
cord-015021-pol2qm74	5002	23	because	because	IN
cord-015021-pol2qm74	5002	24	of	of	IN
cord-015021-pol2qm74	5002	25	the	the	DT
cord-015021-pol2qm74	5002	26	higher	high	JJR
cord-015021-pol2qm74	5002	27	SP	SP	NNP
cord-015021-pol2qm74	5002	28	-	-	HYPH
cord-015021-pol2qm74	5002	29	A	A	NNP
cord-015021-pol2qm74	5002	30	levels	level	NNS
cord-015021-pol2qm74	5002	31	observed	observe	VBN
cord-015021-pol2qm74	5002	32	in	in	IN
cord-015021-pol2qm74	5002	33	the	the	DT
cord-015021-pol2qm74	5002	34	ARDS	ARDS	NNP
cord-015021-pol2qm74	5002	35	patients	patient	NNS
cord-015021-pol2qm74	5002	36	.	.	.
cord-015021-pol2qm74	5003	1	However	however	RB
cord-015021-pol2qm74	5003	2	it	-PRON-	PRP
cord-015021-pol2qm74	5003	3	is	be	VBZ
cord-015021-pol2qm74	5003	4	also	also	RB
cord-015021-pol2qm74	5003	5	likely	likely	JJ
cord-015021-pol2qm74	5003	6	that	that	IN
cord-015021-pol2qm74	5003	7	higher	high	JJR
cord-015021-pol2qm74	5003	8	serum	serum	NN
cord-015021-pol2qm74	5003	9	SP	sp	NN
cord-015021-pol2qm74	5003	10	-	-	HYPH
cord-015021-pol2qm74	5003	11	A	a	DT
cord-015021-pol2qm74	5003	12	level	level	NN
cord-015021-pol2qm74	5003	13	represents	represent	VBZ
cord-015021-pol2qm74	5003	14	the	the	DT
cord-015021-pol2qm74	5003	15	proliferation	proliferation	NN
cord-015021-pol2qm74	5003	16	of	of	IN
cord-015021-pol2qm74	5003	17	alveolar	alveolar	JJ
cord-015021-pol2qm74	5003	18	type	type	NN
cord-015021-pol2qm74	5003	19	II	ii	CD
cord-015021-pol2qm74	5003	20	cells	cell	NNS
cord-015021-pol2qm74	5003	21	as	as	IN
cord-015021-pol2qm74	5003	22	the	the	DT
cord-015021-pol2qm74	5003	23	regeneration	regeneration	NN
cord-015021-pol2qm74	5003	24	of	of	IN
cord-015021-pol2qm74	5003	25	damaged	damaged	JJ
cord-015021-pol2qm74	5003	26	lung	lung	NN
cord-015021-pol2qm74	5003	27	.	.	.
cord-015021-pol2qm74	5004	1	Further	further	JJ
cord-015021-pol2qm74	5004	2	studies	study	NNS
cord-015021-pol2qm74	5004	3	are	be	VBP
cord-015021-pol2qm74	5004	4	now	now	RB
cord-015021-pol2qm74	5004	5	being	be	VBG
cord-015021-pol2qm74	5004	6	done	do	VBN
cord-015021-pol2qm74	5004	7	.	.	.
cord-015021-pol2qm74	5005	1	Neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5005	2	contain	contain	VBP
cord-015021-pol2qm74	5005	3	a	a	DT
cord-015021-pol2qm74	5005	4	number	number	NN
cord-015021-pol2qm74	5005	5	of	of	IN
cord-015021-pol2qm74	5005	6	enzymes	enzyme	NNS
cord-015021-pol2qm74	5005	7	within	within	IN
cord-015021-pol2qm74	5005	8	intracellular	intracellular	JJ
cord-015021-pol2qm74	5005	9	granules	granule	NNS
cord-015021-pol2qm74	5005	10	,	,	,
cord-015021-pol2qm74	5005	11	potentially	potentially	RB
cord-015021-pol2qm74	5005	12	damagingto	damagingto	NN
cord-015021-pol2qm74	5005	13	lung	lung	NN
cord-015021-pol2qm74	5005	14	tissue	tissue	NN
cord-015021-pol2qm74	5005	15	.	.	.
cord-015021-pol2qm74	5006	1	Release	release	NN
cord-015021-pol2qm74	5006	2	of	of	IN
cord-015021-pol2qm74	5006	3	these	these	DT
cord-015021-pol2qm74	5006	4	enzymes	enzyme	NNS
cord-015021-pol2qm74	5006	5	into	into	IN
cord-015021-pol2qm74	5006	6	the	the	DT
cord-015021-pol2qm74	5006	7	lung	lung	NN
cord-015021-pol2qm74	5006	8	tissue	tissue	NN
cord-015021-pol2qm74	5006	9	from	from	IN
cord-015021-pol2qm74	5006	10	the	the	DT
cord-015021-pol2qm74	5006	11	sequestred	sequestred	NNP
cord-015021-pol2qm74	5006	12	activated	activate	VBN
cord-015021-pol2qm74	5006	13	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5006	14	is	be	VBZ
cord-015021-pol2qm74	5006	15	felt	feel	VBN
cord-015021-pol2qm74	5006	16	to	to	TO
cord-015021-pol2qm74	5006	17	play	play	VB
cord-015021-pol2qm74	5006	18	significant	significant	JJ
cord-015021-pol2qm74	5006	19	role	role	NN
cord-015021-pol2qm74	5006	20	in	in	IN
cord-015021-pol2qm74	5006	21	lung	lung	NN
cord-015021-pol2qm74	5006	22	injury	injury	NN
cord-015021-pol2qm74	5006	23	in	in	IN
cord-015021-pol2qm74	5006	24	the	the	DT
cord-015021-pol2qm74	5006	25	course	course	NN
cord-015021-pol2qm74	5006	26	of	of	IN
cord-015021-pol2qm74	5006	27	AROS	AROS	NNP
cord-015021-pol2qm74	5006	28	.	.	.
cord-015021-pol2qm74	5007	1	Using	use	VBG
cord-015021-pol2qm74	5007	2	6-hours	6-hours	CD
cord-015021-pol2qm74	5007	3	acute	acute	JJ
cord-015021-pol2qm74	5007	4	animal	animal	NN
cord-015021-pol2qm74	5007	5	model	model	NN
cord-015021-pol2qm74	5007	6	of	of	IN
cord-015021-pol2qm74	5007	7	AROS	AROS	NNP
cord-015021-pol2qm74	5007	8	the	the	DT
cord-015021-pol2qm74	5007	9	activity	activity	NN
cord-015021-pol2qm74	5007	10	of	of	IN
cord-015021-pol2qm74	5007	11	cathepsins	cathepsin	NNS
cord-015021-pol2qm74	5007	12	,	,	,
cord-015021-pol2qm74	5007	13	beta	beta	NN
cord-015021-pol2qm74	5007	14	-	-	HYPH
cord-015021-pol2qm74	5007	15	glucuronidase	glucuronidase	NN
cord-015021-pol2qm74	5007	16	and	and	CC
cord-015021-pol2qm74	5007	17	acid	acid	NN
cord-015021-pol2qm74	5007	18	phosphatase	phosphatase	NN
cord-015021-pol2qm74	5007	19	was	be	VBD
cord-015021-pol2qm74	5007	20	determined	determine	VBN
cord-015021-pol2qm74	5007	21	in	in	IN
cord-015021-pol2qm74	5007	22	the	the	DT
cord-015021-pol2qm74	5007	23	lung	lung	NN
cord-015021-pol2qm74	5007	24	tissue	tissue	NN
cord-015021-pol2qm74	5007	25	.	.	.
cord-015021-pol2qm74	5008	1	Results	result	NNS
cord-015021-pol2qm74	5008	2	of	of	IN
cord-015021-pol2qm74	5008	3	this	this	DT
cord-015021-pol2qm74	5008	4	research	research	NN
cord-015021-pol2qm74	5008	5	were	be	VBD
cord-015021-pol2qm74	5008	6	compared	compare	VBN
cord-015021-pol2qm74	5008	7	with	with	IN
cord-015021-pol2qm74	5008	8	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5008	9	proteases	protease	NNS
cord-015021-pol2qm74	5008	10	activity	activity	NN
cord-015021-pol2qm74	5008	11	in	in	IN
cord-015021-pol2qm74	5008	12	serum	serum	NN
cord-015021-pol2qm74	5008	13	and	and	CC
cord-015021-pol2qm74	5008	14	broncho	broncho	JJ
cord-015021-pol2qm74	5008	15	-	-	HYPH
cord-015021-pol2qm74	5008	16	alveolar	alveolar	NN
cord-015021-pol2qm74	5008	17	lavage	lavage	NN
cord-015021-pol2qm74	5008	18	.	.	.
cord-015021-pol2qm74	5009	1	Also	also	RB
cord-015021-pol2qm74	5009	2	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	5009	3	,	,	,
cord-015021-pol2qm74	5009	4	respiratory	respiratory	JJ
cord-015021-pol2qm74	5009	5	and	and	CC
cord-015021-pol2qm74	5009	6	biochemical	biochemical	JJ
cord-015021-pol2qm74	5009	7	investigations	investigation	NNS
cord-015021-pol2qm74	5009	8	were	be	VBD
cord-015021-pol2qm74	5009	9	performed	perform	VBN
cord-015021-pol2qm74	5009	10	before	before	IN
cord-015021-pol2qm74	5009	11	beginning	beginning	NN
cord-015021-pol2qm74	5009	12	of	of	IN
cord-015021-pol2qm74	5009	13	experiment	experiment	NN
cord-015021-pol2qm74	5009	14	,	,	,
cord-015021-pol2qm74	5009	15	and	and	CC
cord-015021-pol2qm74	5009	16	in	in	IN
cord-015021-pol2qm74	5009	17	a	a	DT
cord-015021-pol2qm74	5009	18	two	two	CD
cord-015021-pol2qm74	5009	19	-	-	HYPH
cord-015021-pol2qm74	5009	20	hours	hour	NNS
cord-015021-pol2qm74	5009	21	time	time	NN
cord-015021-pol2qm74	5009	22	intervals	interval	NNS
cord-015021-pol2qm74	5009	23	of	of	IN
cord-015021-pol2qm74	5009	24	its	-PRON-	PRP$
cord-015021-pol2qm74	5009	25	duration	duration	NN
cord-015021-pol2qm74	5009	26	.	.	.
cord-015021-pol2qm74	5010	1	After	after	IN
cord-015021-pol2qm74	5010	2	6	6	CD
cord-015021-pol2qm74	5010	3	hours	hour	NNS
cord-015021-pol2qm74	5010	4	was	be	VBD
cord-015021-pol2qm74	5010	5	determined	determine	VBN
cord-015021-pol2qm74	5010	6	total	total	JJ
cord-015021-pol2qm74	5010	7	and	and	CC
cord-015021-pol2qm74	5010	8	free	free	JJ
cord-015021-pol2qm74	5010	9	activity	activity	NN
cord-015021-pol2qm74	5010	10	of	of	IN
cord-015021-pol2qm74	5010	11	cathepsins	cathepsin	NNS
cord-015021-pol2qm74	5010	12	,	,	,
cord-015021-pol2qm74	5010	13	beta	beta	NN
cord-015021-pol2qm74	5010	14	-	-	HYPH
cord-015021-pol2qm74	5010	15	glucuronidase	glucuronidase	NN
cord-015021-pol2qm74	5010	16	and	and	CC
cord-015021-pol2qm74	5010	17	acid	acid	NN
cord-015021-pol2qm74	5010	18	phosphatase	phosphatase	NN
cord-015021-pol2qm74	5010	19	in	in	IN
cord-015021-pol2qm74	5010	20	full	full	JJ
cord-015021-pol2qm74	5010	21	homogenate	homogenate	NN
cord-015021-pol2qm74	5010	22	of	of	IN
cord-015021-pol2qm74	5010	23	the	the	DT
cord-015021-pol2qm74	5010	24	lung	lung	NN
cord-015021-pol2qm74	5010	25	tissue	tissue	NN
cord-015021-pol2qm74	5010	26	,	,	,
cord-015021-pol2qm74	5010	27	mitochondriallysosomal	mitochondriallysosomal	NNP
cord-015021-pol2qm74	5010	28	fraction	fraction	NN
cord-015021-pol2qm74	5010	29	and	and	CC
cord-015021-pol2qm74	5010	30	the	the	DT
cord-015021-pol2qm74	5010	31	final	final	JJ
cord-015021-pol2qm74	5010	32	supernatant	supernatant	NN
cord-015021-pol2qm74	5010	33	.	.	.
cord-015021-pol2qm74	5011	1	In	in	IN
cord-015021-pol2qm74	5011	2	the	the	DT
cord-015021-pol2qm74	5011	3	course	course	NN
cord-015021-pol2qm74	5011	4	of	of	IN
cord-015021-pol2qm74	5011	5	our	-PRON-	PRP$
cord-015021-pol2qm74	5011	6	experiment	experiment	NN
cord-015021-pol2qm74	5011	7	we	-PRON-	PRP
cord-015021-pol2qm74	5011	8	observed	observe	VBD
cord-015021-pol2qm74	5011	9	an	an	DT
cord-015021-pol2qm74	5011	10	increase	increase	NN
cord-015021-pol2qm74	5011	11	(	(	-LRB-
cord-015021-pol2qm74	5011	12	30.i-49.6	30.i-49.6	CD
cord-015021-pol2qm74	5011	13	%	%	NN
cord-015021-pol2qm74	5011	14	)	)	-RRB-
cord-015021-pol2qm74	5011	15	both	both	CC
cord-015021-pol2qm74	5011	16	total	total	VBP
cord-015021-pol2qm74	5011	17	and	and	CC
cord-015021-pol2qm74	5011	18	free	free	JJ
cord-015021-pol2qm74	5011	19	activity	activity	NN
cord-015021-pol2qm74	5011	20	of	of	IN
cord-015021-pol2qm74	5011	21	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5011	22	proteases	protease	NNS
cord-015021-pol2qm74	5011	23	in	in	IN
cord-015021-pol2qm74	5011	24	all	all	DT
cord-015021-pol2qm74	5011	25	fractions	fraction	NNS
cord-015021-pol2qm74	5011	26	of	of	IN
cord-015021-pol2qm74	5011	27	the	the	DT
cord-015021-pol2qm74	5011	28	lung	lung	NN
cord-015021-pol2qm74	5011	29	tissue	tissue	NN
cord-015021-pol2qm74	5011	30	.	.	.
cord-015021-pol2qm74	5012	1	Generally	generally	RB
cord-015021-pol2qm74	5012	2	accepted	accept	VBN
cord-015021-pol2qm74	5012	3	current	current	JJ
cord-015021-pol2qm74	5012	4	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	5012	5	treatment	treatment	NN
cord-015021-pol2qm74	5012	6	of	of	IN
cord-015021-pol2qm74	5012	7	AROS	AROS	NNP
cord-015021-pol2qm74	5012	8	only	only	RB
cord-015021-pol2qm74	5012	9	attenuated	attenuate	VBD
cord-015021-pol2qm74	5012	10	this	this	DT
cord-015021-pol2qm74	5012	11	increase	increase	NN
cord-015021-pol2qm74	5012	12	but	but	CC
cord-015021-pol2qm74	5012	13	never	never	RB
cord-015021-pol2qm74	5012	14	caused	cause	VBD
cord-015021-pol2qm74	5012	15	reversion	reversion	NN
cord-015021-pol2qm74	5012	16	to	to	IN
cord-015021-pol2qm74	5012	17	the	the	DT
cord-015021-pol2qm74	5012	18	level	level	NN
cord-015021-pol2qm74	5012	19	before	before	IN
cord-015021-pol2qm74	5012	20	beginning	beginning	NN
cord-015021-pol2qm74	5012	21	of	of	IN
cord-015021-pol2qm74	5012	22	our	-PRON-	PRP$
cord-015021-pol2qm74	5012	23	investigations	investigation	NNS
cord-015021-pol2qm74	5012	24	.	.	.
cord-015021-pol2qm74	5013	1	The	the	DT
cord-015021-pol2qm74	5013	2	presence	presence	NN
cord-015021-pol2qm74	5013	3	of	of	IN
cord-015021-pol2qm74	5013	4	AROS	AROS	NNP
cord-015021-pol2qm74	5013	5	was	be	VBD
cord-015021-pol2qm74	5013	6	histologically	histologically	RB
cord-015021-pol2qm74	5013	7	proved	prove	VBN
cord-015021-pol2qm74	5013	8	.	.	.
cord-015021-pol2qm74	5014	1	An	an	DT
cord-015021-pol2qm74	5014	2	activity	activity	NN
cord-015021-pol2qm74	5014	3	of	of	IN
cord-015021-pol2qm74	5014	4	acid	acid	JJ
cord-015021-pol2qm74	5014	5	phosphatase	phosphatase	NN
cord-015021-pol2qm74	5014	6	in	in	IN
cord-015021-pol2qm74	5014	7	serum	serum	NN
cord-015021-pol2qm74	5014	8	and	and	CC
cord-015021-pol2qm74	5014	9	the	the	DT
cord-015021-pol2qm74	5014	10	lung	lung	NN
cord-015021-pol2qm74	5014	11	tissue	tissue	NN
cord-015021-pol2qm74	5014	12	fractions	fraction	NNS
cord-015021-pol2qm74	5014	13	was	be	VBD
cord-015021-pol2qm74	5014	14	compared	compare	VBN
cord-015021-pol2qm74	5014	15	with	with	IN
cord-015021-pol2qm74	5014	16	histochemical	histochemical	JJ
cord-015021-pol2qm74	5014	17	pictures	picture	NNS
cord-015021-pol2qm74	5014	18	of	of	IN
cord-015021-pol2qm74	5014	19	the	the	DT
cord-015021-pol2qm74	5014	20	lung	lung	NN
cord-015021-pol2qm74	5014	21	.	.	.
cord-015021-pol2qm74	5015	1	Results	result	NNS
cord-015021-pol2qm74	5015	2	of	of	IN
cord-015021-pol2qm74	5015	3	our	-PRON-	PRP$
cord-015021-pol2qm74	5015	4	research	research	NN
cord-015021-pol2qm74	5015	5	indicate	indicate	VBP
cord-015021-pol2qm74	5015	6	that	that	IN
cord-015021-pol2qm74	5015	7	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5015	8	proteases	protease	NNS
cord-015021-pol2qm74	5015	9	are	be	VBP
cord-015021-pol2qm74	5015	10	a	a	DT
cord-015021-pol2qm74	5015	11	very	very	RB
cord-015021-pol2qm74	5015	12	important	important	JJ
cord-015021-pol2qm74	5015	13	mediators	mediator	NNS
cord-015021-pol2qm74	5015	14	in	in	IN
cord-015021-pol2qm74	5015	15	AROS	AROS	NNP
cord-015021-pol2qm74	5015	16	and	and	CC
cord-015021-pol2qm74	5015	17	they	-PRON-	PRP
cord-015021-pol2qm74	5015	18	are	be	VBP
cord-015021-pol2qm74	5015	19	a	a	DT
cord-015021-pol2qm74	5015	20	cause	cause	NN
cord-015021-pol2qm74	5015	21	of	of	IN
cord-015021-pol2qm74	5015	22	the	the	DT
cord-015021-pol2qm74	5015	23	lung	lung	NN
cord-015021-pol2qm74	5015	24	injury	injury	NN
cord-015021-pol2qm74	5015	25	.	.	.
cord-015021-pol2qm74	5016	1	In	in	IN
cord-015021-pol2qm74	5016	2	addition	addition	NN
cord-015021-pol2qm74	5016	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5016	4	-	-	HYPH
cord-015021-pol2qm74	5016	5	derived	derive	VBN
cord-015021-pol2qm74	5016	6	proteases	protease	NNS
cord-015021-pol2qm74	5016	7	can	can	MD
cord-015021-pol2qm74	5016	8	amplify	amplify	VB
cord-015021-pol2qm74	5016	9	the	the	DT
cord-015021-pol2qm74	5016	10	inflamatory	inflamatory	JJ
cord-015021-pol2qm74	5016	11	process	process	NN
cord-015021-pol2qm74	5016	12	by	by	IN
cord-015021-pol2qm74	5016	13	enzymatitally	enzymatitally	RB
cord-015021-pol2qm74	5016	14	activating	activate	VBG
cord-015021-pol2qm74	5016	15	of	of	IN
cord-015021-pol2qm74	5016	16	many	many	JJ
cord-015021-pol2qm74	5016	17	other	other	JJ
cord-015021-pol2qm74	5016	18	mediators	mediator	NNS
cord-015021-pol2qm74	5016	19	and	and	CC
cord-015021-pol2qm74	5016	20	they	-PRON-	PRP
cord-015021-pol2qm74	5016	21	also	also	RB
cord-015021-pol2qm74	5016	22	may	may	MD
cord-015021-pol2qm74	5016	23	to	to	TO
cord-015021-pol2qm74	5016	24	increase	increase	VB
cord-015021-pol2qm74	5016	25	an	an	DT
cord-015021-pol2qm74	5016	26	oxidant	oxidant	JJ
cord-015021-pol2qm74	5016	27	induced	induce	VBN
cord-015021-pol2qm74	5016	28	injury	injury	NN
cord-015021-pol2qm74	5016	29	by	by	IN
cord-015021-pol2qm74	5016	30	imparing	imparing	NN
cord-015021-pol2qm74	5016	31	of	of	IN
cord-015021-pol2qm74	5016	32	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	5016	33	defenses	defense	NNS
cord-015021-pol2qm74	5016	34	.	.	.
cord-015021-pol2qm74	5017	1	Oepartment	Oepartment	NNP
cord-015021-pol2qm74	5017	2	of	of	IN
cord-015021-pol2qm74	5017	3	General	General	NNP
cord-015021-pol2qm74	5017	4	Surgery	Surgery	NNP
cord-015021-pol2qm74	5017	5	,	,	,
cord-015021-pol2qm74	5017	6	Sk	Sk	NNP
cord-015021-pol2qm74	5017	7	~	~	NNP
cord-015021-pol2qm74	5017	8	odowskiej	odowskiej	NN
cord-015021-pol2qm74	5017	9	24a	24a	.
cord-015021-pol2qm74	5018	1	15	15	CD
cord-015021-pol2qm74	5018	2	-	-	SYM
cord-015021-pol2qm74	5018	3	276	276	CD
cord-015021-pol2qm74	5018	4	~ia	~ia	NNS
cord-015021-pol2qm74	5018	5	~	~	NFP
cord-015021-pol2qm74	5018	6	ystok	ystok	NNP
cord-015021-pol2qm74	5018	7	,	,	,
cord-015021-pol2qm74	5018	8	Poland	Poland	NNP
cord-015021-pol2qm74	5018	9	,	,	,
cord-015021-pol2qm74	5018	10	tel	tel	NNP
cord-015021-pol2qm74	5018	11	/	/	SYM
cord-015021-pol2qm74	5018	12	fax	fax	NN
cord-015021-pol2qm74	5018	13	+48	+48	NNP
cord-015021-pol2qm74	5018	14	85	85	CD
cord-015021-pol2qm74	5018	15	619742	619742	CD
cord-015021-pol2qm74	5018	16	.	.	.
cord-015021-pol2qm74	5019	1	In	in	IN
cord-015021-pol2qm74	5019	2	vitro	vitro	FW
cord-015021-pol2qm74	5019	3	studies	study	NNS
cord-015021-pol2qm74	5019	4	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	5019	5	that	that	IN
cord-015021-pol2qm74	5019	6	PAF	PAF	NNP
cord-015021-pol2qm74	5019	7	activates	activate	VBZ
cord-015021-pol2qm74	5019	8	polymorplionuclear	polymorplionuclear	JJ
cord-015021-pol2qm74	5019	9	leukocyte	leukocyte	NN
cord-015021-pol2qm74	5019	10	(	(	-LRB-
cord-015021-pol2qm74	5019	11	PMN	PMN	NNP
cord-015021-pol2qm74	5019	12	)	)	-RRB-
cord-015021-pol2qm74	5019	13	5	5	CD
cord-015021-pol2qm74	5019	14	-	-	SYM
cord-015021-pol2qm74	5019	15	1ipoxygenase	1ipoxygenase	CD
cord-015021-pol2qm74	5019	16	,	,	,
cord-015021-pol2qm74	5019	17	but	but	CC
cord-015021-pol2qm74	5019	18	the	the	DT
cord-015021-pol2qm74	5019	19	generation	generation	NN
cord-015021-pol2qm74	5019	20	of	of	IN
cord-015021-pol2qm74	5019	21	leukotrienes	leukotriene	NNS
cord-015021-pol2qm74	5019	22	(	(	-LRB-
cord-015021-pol2qm74	5019	23	LTs	LTs	NNP
cord-015021-pol2qm74	5019	24	)	)	-RRB-
cord-015021-pol2qm74	5019	25	is	be	VBZ
cord-015021-pol2qm74	5019	26	critically	critically	RB
cord-015021-pol2qm74	5019	27	dependent	dependent	JJ
cord-015021-pol2qm74	5019	28	on	on	IN
cord-015021-pol2qm74	5019	29	exogenous	exogenous	JJ
cord-015021-pol2qm74	5019	30	arachidunic	arachidunic	JJ
cord-015021-pol2qm74	5019	31	acid	acid	NN
cord-015021-pol2qm74	5019	32	(	(	-LRB-
cord-015021-pol2qm74	5019	33	AA	AA	NNP
cord-015021-pol2qm74	5019	34	)	)	-RRB-
cord-015021-pol2qm74	5019	35	disposal	disposal	NN
cord-015021-pol2qm74	5020	1	(	(	-LRB-
cord-015021-pol2qm74	5020	2	F.	F.	NNP
cord-015021-pol2qm74	5020	3	Grimminger	Grimminger	NNP
cord-015021-pol2qm74	5020	4	et	et	FW
cord-015021-pol2qm74	5020	5	at	at	IN
cord-015021-pol2qm74	5020	6	.	.	.
cord-015021-pol2qm74	5020	7	,	,	,
cord-015021-pol2qm74	5020	8	Mol	Mol	NNP
cord-015021-pol2qm74	5020	9	.	.	.
cord-015021-pol2qm74	5021	1	Pharmacol	Pharmacol	NNP
cord-015021-pol2qm74	5021	2	.	.	.
cord-015021-pol2qm74	5022	1	41:757	41:757	CD
cord-015021-pol2qm74	5022	2	,	,	,
cord-015021-pol2qm74	5022	3	1992	1992	CD
cord-015021-pol2qm74	5022	4	)	)	-RRB-
cord-015021-pol2qm74	5022	5	.	.	.
cord-015021-pol2qm74	5023	1	We	-PRON-	PRP
cord-015021-pol2qm74	5023	2	investigated	investigate	VBD
cord-015021-pol2qm74	5023	3	the	the	DT
cord-015021-pol2qm74	5023	4	features	feature	NNS
cord-015021-pol2qm74	5023	5	of	of	IN
cord-015021-pol2qm74	5023	6	PAF	PAF	NNP
cord-015021-pol2qm74	5023	7	-	-	HYPH
cord-015021-pol2qm74	5023	8	evoked	evoke	VBN
cord-015021-pol2qm74	5023	9	LT	LT	NNP
cord-015021-pol2qm74	5023	10	synthesis	synthesis	NN
cord-015021-pol2qm74	5023	11	in	in	IN
cord-015021-pol2qm74	5023	12	a	a	DT
cord-015021-pol2qm74	5023	13	model	model	NN
cord-015021-pol2qm74	5023	14	of	of	IN
cord-015021-pol2qm74	5023	15	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	5023	16	microvascular	microvascular	JJ
cord-015021-pol2qm74	5023	17	leukostasis	leukostasis	NN
cord-015021-pol2qm74	5023	18	,	,	,
cord-015021-pol2qm74	5023	19	in	in	IN
cord-015021-pol2qm74	5023	20	the	the	DT
cord-015021-pol2qm74	5023	21	presence	presence	NN
cord-015021-pol2qm74	5023	22	and	and	CC
cord-015021-pol2qm74	5023	23	absence	absence	NN
cord-015021-pol2qm74	5023	24	of	of	IN
cord-015021-pol2qm74	5023	25	intravascular	intravascular	JJ
cord-015021-pol2qm74	5024	1	n-3-and	n-3-and	JJR
cord-015021-pol2qm74	5024	2	n-6	n-6	NN
cord-015021-pol2qm74	5024	3	-prescursor	-prescursor	VBP
cord-015021-pol2qm74	5024	4	fatty	fatty	JJ
cord-015021-pol2qm74	5024	5	acid	acid	NN
cord-015021-pol2qm74	5024	6	supply	supply	NN
cord-015021-pol2qm74	5024	7	.	.	.
cord-015021-pol2qm74	5025	1	Human	human	JJ
cord-015021-pol2qm74	5025	2	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5025	3	were	be	VBD
cord-015021-pol2qm74	5025	4	infused	infuse	VBN
cord-015021-pol2qm74	5025	5	into	into	IN
cord-015021-pol2qm74	5025	6	isolated	isolate	VBN
cord-015021-pol2qm74	5025	7	,	,	,
cord-015021-pol2qm74	5025	8	ventilated	ventilate	VBN
cord-015021-pol2qm74	5025	9	and	and	CC
cord-015021-pol2qm74	5025	10	perfused	perfuse	VBN
cord-015021-pol2qm74	5025	11	rabbit	rabbit	NN
cord-015021-pol2qm74	5025	12	lungs	lung	NNS
cord-015021-pol2qm74	5025	13	to	to	TO
cord-015021-pol2qm74	5025	14	achieve	achieve	VB
cord-015021-pol2qm74	5025	15	microvascular	microvascular	JJ
cord-015021-pol2qm74	5025	16	sequestration	sequestration	NN
cord-015021-pol2qm74	5025	17	of	of	IN
cord-015021-pol2qm74	5025	18	ligand	ligand	NN
cord-015021-pol2qm74	5025	19	-	-	HYPH
cord-015021-pol2qm74	5025	20	responsive	responsive	JJ
cord-015021-pol2qm74	5025	21	leukecytes	leukecyte	NNS
cord-015021-pol2qm74	5025	22	.	.	.
cord-015021-pol2qm74	5026	1	Leukotrienes	leukotriene	NNS
cord-015021-pol2qm74	5026	2	(	(	-LRB-
cord-015021-pol2qm74	5026	3	LT	LT	NNP
cord-015021-pol2qm74	5026	4	)	)	-RRB-
cord-015021-pol2qm74	5026	5	and	and	CC
cord-015021-pol2qm74	5026	6	hydroxyeicosatetra(penta)enoic	hydroxyeicosatetra(penta)enoic	NNP
cord-015021-pol2qm74	5026	7	acids	acid	NNS
cord-015021-pol2qm74	5026	8	(	(	-LRB-
cord-015021-pol2qm74	5026	9	HET(P)E	HET(P)E	NNP
cord-015021-pol2qm74	5026	10	)	)	-RRB-
cord-015021-pol2qm74	5026	11	were	be	VBD
cord-015021-pol2qm74	5026	12	quantified	quantify	VBN
cord-015021-pol2qm74	5026	13	by	by	IN
cord-015021-pol2qm74	5026	14	ItPLC	itplc	NN
cord-015021-pol2qm74	5026	15	techniques	technique	NNS
cord-015021-pol2qm74	5026	16	.	.	.
cord-015021-pol2qm74	5027	1	Intravascular	Intravascular	NNP
cord-015021-pol2qm74	5027	2	application	application	NN
cord-015021-pol2qm74	5027	3	of	of	IN
cord-015021-pol2qm74	5027	4	PAF	PAF	NNP
cord-015021-pol2qm74	5027	5	(	(	-LRB-
cord-015021-pol2qm74	5027	6	5	5	CD
cord-015021-pol2qm74	5027	7	uM	um	UH
cord-015021-pol2qm74	5027	8	)	)	-RRB-
cord-015021-pol2qm74	5027	9	or	or	CC
cord-015021-pol2qm74	5027	10	arachidonic	arachidonic	JJ
cord-015021-pol2qm74	5027	11	acid	acid	NN
cord-015021-pol2qm74	5027	12	(	(	-LRB-
cord-015021-pol2qm74	5027	13	AA;IOuM	AA;IOuM	NNP
cord-015021-pol2qm74	5027	14	)	)	-RRB-
cord-015021-pol2qm74	5027	15	provoked	provoke	VBD
cord-015021-pol2qm74	5027	16	the	the	DT
cord-015021-pol2qm74	5027	17	generation	generation	NN
cord-015021-pol2qm74	5027	18	of	of	IN
cord-015021-pol2qm74	5027	19	limited	limited	JJ
cord-015021-pol2qm74	5027	20	quantities	quantity	NNS
cord-015021-pol2qm74	5027	21	of	of	IN
cord-015021-pol2qm74	5027	22	4-series	4-series	CD
cord-015021-pol2qm74	5027	23	LTs	lt	NNS
cord-015021-pol2qm74	5027	24	and	and	CC
cord-015021-pol2qm74	5027	25	5-HETE	5-HETE	NNP
cord-015021-pol2qm74	5027	26	(	(	-LRB-
cord-015021-pol2qm74	5027	27	total	total	JJ
cord-015021-pol2qm74	5027	28	sum	sum	NN
cord-015021-pol2qm74	5027	29	of	of	IN
cord-015021-pol2qm74	5027	30	5	5	CD
cord-015021-pol2qm74	5027	31	-	-	HYPH
cord-015021-pol2qm74	5027	32	1ipoxygenade	1ipoxygenade	CD
cord-015021-pol2qm74	5027	33	products	product	NNS
cord-015021-pol2qm74	5027	34	rd	rd	NNP
cord-015021-pol2qm74	5027	35	.	.	NNP
cord-015021-pol2qm74	5027	36	7	7	CD
cord-015021-pol2qm74	5027	37	and	and	CC
cord-015021-pol2qm74	5027	38	rd	rd	NNP
cord-015021-pol2qm74	5027	39	.	.	.
cord-015021-pol2qm74	5028	1	27	27	CD
cord-015021-pol2qm74	5028	2	pmol	pmol	NN
cord-015021-pol2qm74	5028	3	/	/	SYM
cord-015021-pol2qm74	5028	4	ml	ml	NN
cord-015021-pol2qm74	5028	5	.	.	NNP
cord-015021-pol2qm74	5028	6	;	;	:
cord-015021-pol2qm74	5028	7	both	both	CC
cord-015021-pol2qm74	5028	8	in	in	IN
cord-015021-pol2qm74	5028	9	PMN	PMN	NNP
cord-015021-pol2qm74	5028	10	-	-	HYPH
cord-015021-pol2qm74	5028	11	preloaded	preloade	VBN
cord-015021-pol2qm74	5028	12	and	and	CC
cord-015021-pol2qm74	5028	13	non	non	JJ
cord-015021-pol2qm74	5028	14	-	-	JJ
cord-015021-pol2qm74	5028	15	preloaded	preloaded	JJ
cord-015021-pol2qm74	5028	16	lungs	lung	NNS
cord-015021-pol2qm74	5028	17	)	)	-RRB-
cord-015021-pol2qm74	5028	18	.	.	.
cord-015021-pol2qm74	5029	1	Combined	combined	JJ
cord-015021-pol2qm74	5029	2	administration	administration	NN
cord-015021-pol2qm74	5029	3	of	of	IN
cord-015021-pol2qm74	5029	4	PAt	PAt	NNP
cord-015021-pol2qm74	5029	5	r	r	NNP
cord-015021-pol2qm74	5029	6	and	and	CC
cord-015021-pol2qm74	5029	7	AA	AA	NNP
cord-015021-pol2qm74	5029	8	caused	cause	VBD
cord-015021-pol2qm74	5029	9	amplification	amplification	NN
cord-015021-pol2qm74	5029	10	of	of	IN
cord-015021-pol2qm74	5029	11	5	5	CD
cord-015021-pol2qm74	5029	12	-	-	SYM
cord-015021-pol2qm74	5029	13	1ipoxygenase	1ipoxygenase	CD
cord-015021-pol2qm74	5029	14	product	product	NN
cord-015021-pol2qm74	5029	15	formation	formation	NN
cord-015021-pol2qm74	5029	16	with	with	IN
cord-015021-pol2qm74	5029	17	predominance	predominance	NN
cord-015021-pol2qm74	5029	18	of	of	IN
cord-015021-pol2qm74	5029	19	cysteinyl	cysteinyl	NNP
cord-015021-pol2qm74	5029	20	-	-	HYPH
cord-015021-pol2qm74	5029	21	LT	LT	NNP
cord-015021-pol2qm74	5029	22	synthesis	synthesis	NN
cord-015021-pol2qm74	5029	23	both	both	DT
cord-015021-pol2qm74	5029	24	in	in	IN
cord-015021-pol2qm74	5029	25	lungs	lung	NNS
cord-015021-pol2qm74	5029	26	without	without	IN
cord-015021-pol2qm74	5029	27	(	(	-LRB-
cord-015021-pol2qm74	5029	28	total	total	JJ
cord-015021-pol2qm74	5029	29	sum	sum	NNP
cord-015021-pol2qm74	5029	30	rd	rd	NNP
cord-015021-pol2qm74	5029	31	.	.	.
cord-015021-pol2qm74	5030	1	67	67	CD
cord-015021-pol2qm74	5030	2	pmol	pmol	NN
cord-015021-pol2qm74	5030	3	/	/	SYM
cord-015021-pol2qm74	5030	4	ml	ml	NN
cord-015021-pol2qm74	5030	5	)	)	-RRB-
cord-015021-pol2qm74	5031	1	and	and	CC
cord-015021-pol2qm74	5031	2	,	,	,
cord-015021-pol2qm74	5031	3	much	much	RB
cord-015021-pol2qm74	5031	4	more	more	RBR
cord-015021-pol2qm74	5031	5	strikingly	strikingly	RB
cord-015021-pol2qm74	5031	6	,	,	,
cord-015021-pol2qm74	5031	7	with	with	IN
cord-015021-pol2qm74	5031	8	pro	pro	JJ
cord-015021-pol2qm74	5031	9	-	-	JJ
cord-015021-pol2qm74	5031	10	application	application	NN
cord-015021-pol2qm74	5031	11	of	of	IN
cord-015021-pol2qm74	5031	12	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5031	13	(	(	-LRB-
cord-015021-pol2qm74	5031	14	total	total	JJ
cord-015021-pol2qm74	5031	15	sum	sum	NNP
cord-015021-pol2qm74	5031	16	rd	rd	NNP
cord-015021-pol2qm74	5031	17	.	.	NNP
cord-015021-pol2qm74	5031	18	308	308	CD
cord-015021-pol2qm74	5031	19	pmoFml	pmoFml	NNP
cord-015021-pol2qm74	5031	20	)	)	-RRB-
cord-015021-pol2qm74	5031	21	.	.	.
cord-015021-pol2qm74	5032	1	Eicosapentaeooic	eicosapentaeooic	NN
cord-015021-pol2qm74	5032	2	acid	acid	NN
cord-015021-pol2qm74	5032	3	(	(	-LRB-
cord-015021-pol2qm74	5032	4	10	10	CD
cord-015021-pol2qm74	5032	5	uM	um	UH
cord-015021-pol2qm74	5032	6	)	)	-RRB-
cord-015021-pol2qm74	5032	7	elicited	elicit	VBD
cord-015021-pol2qm74	5032	8	exclusive	exclusive	JJ
cord-015021-pol2qm74	5032	9	generation	generation	NN
cord-015021-pol2qm74	5032	10	of	of	IN
cord-015021-pol2qm74	5032	11	5-series	5-series	CD
cord-015021-pol2qm74	5032	12	LTs	lt	NNS
cord-015021-pol2qm74	5032	13	and	and	CC
cord-015021-pol2qm74	5032	14	5-HEPE	5-hepe	CD
cord-015021-pol2qm74	5032	15	(	(	-LRB-
cord-015021-pol2qm74	5032	16	total	total	JJ
cord-015021-pol2qm74	5032	17	sum	sum	NNP
cord-015021-pol2qm74	5032	18	rd	rd	NNP
cord-015021-pol2qm74	5032	19	.	.	.
cord-015021-pol2qm74	5033	1	82	82	CD
cord-015021-pol2qm74	5033	2	pmol	pmol	NNP
cord-015021-pol2qm74	5033	3	/	/	SYM
cord-015021-pol2qm74	5033	4	mi	mi	NNP
cord-015021-pol2qm74	5033	5	)	)	-RRB-
cord-015021-pol2qm74	5033	6	.	.	.
cord-015021-pol2qm74	5034	1	Dual	dual	JJ
cord-015021-pol2qm74	5034	2	stimulation	stimulation	NN
cord-015021-pol2qm74	5034	3	with	with	IN
cord-015021-pol2qm74	5034	4	PAF	PAF	NNP
cord-015021-pol2qm74	5034	5	and	and	CC
cord-015021-pol2qm74	5034	6	EPA	EPA	NNP
cord-015021-pol2qm74	5034	7	provoked	provoke	VBD
cord-015021-pol2qm74	5034	8	amplification	amplification	NN
cord-015021-pol2qm74	5034	9	of	of	IN
cord-015021-pol2qm74	5034	10	EPA	EPA	NNP
cord-015021-pol2qm74	5034	11	-	-	HYPH
cord-015021-pol2qm74	5034	12	derived	derive	VBN
cord-015021-pol2qm74	5034	13	5	5	CD
cord-015021-pol2qm74	5034	14	-	-	SYM
cord-015021-pol2qm74	5034	15	1ipoxygenase	1ipoxygenase	CD
cord-015021-pol2qm74	5034	16	product	product	NN
cord-015021-pol2qm74	5034	17	formation	formation	NN
cord-015021-pol2qm74	5034	18	,	,	,
cord-015021-pol2qm74	5034	19	again	again	RB
cord-015021-pol2qm74	5034	20	with	with	IN
cord-015021-pol2qm74	5034	21	predominance	predominance	NN
cord-015021-pol2qm74	5034	22	of	of	IN
cord-015021-pol2qm74	5034	23	cysteinyl	cysteinyl	NNP
cord-015021-pol2qm74	5034	24	-	-	HYPH
cord-015021-pol2qm74	5034	25	LTs	LTs	NNPS
cord-015021-pol2qm74	5034	26	,	,	,
cord-015021-pol2qm74	5034	27	in	in	IN
cord-015021-pol2qm74	5034	28	lungs	lung	NNS
cord-015021-pol2qm74	5034	29	without	without	IN
cord-015021-pol2qm74	5034	30	(	(	-LRB-
cord-015021-pol2qm74	5034	31	total	total	JJ
cord-015021-pol2qm74	5034	32	sum	sum	NNP
cord-015021-pol2qm74	5034	33	rd	rd	NNP
cord-015021-pol2qm74	5034	34	.	.	.
cord-015021-pol2qm74	5035	1	224	224	CD
cord-015021-pol2qm74	5035	2	pmul	pmul	NNS
cord-015021-pol2qm74	5035	3	/	/	SYM
cord-015021-pol2qm74	5035	4	ml	ml	NN
cord-015021-pol2qm74	5035	5	)	)	-RRB-
cord-015021-pol2qm74	5035	6	and	and	CC
cord-015021-pol2qm74	5036	1	in	in	IN
cord-015021-pol2qm74	5036	2	particular	particular	JJ
cord-015021-pol2qm74	5036	3	in	in	IN
cord-015021-pol2qm74	5036	4	those	those	DT
cord-015021-pol2qm74	5036	5	with	with	IN
cord-015021-pol2qm74	5036	6	preceding	precede	VBG
cord-015021-pol2qm74	5036	7	microvascular	microvascular	JJ
cord-015021-pol2qm74	5036	8	PMN	PMN	NNP
cord-015021-pol2qm74	5036	9	entrapment	entrapment	NN
cord-015021-pol2qm74	5036	10	(	(	-LRB-
cord-015021-pol2qm74	5036	11	total	total	JJ
cord-015021-pol2qm74	5036	12	sum	sum	NNP
cord-015021-pol2qm74	5036	13	rd	rd	NNP
cord-015021-pol2qm74	5036	14	.	.	.
cord-015021-pol2qm74	5037	1	545	545	CD
cord-015021-pol2qm74	5037	2	pmol	pmol	NN
cord-015021-pol2qm74	5037	3	/	/	SYM
cord-015021-pol2qm74	5037	4	ml	ml	NN
cord-015021-pol2qm74	5037	5	)	)	-RRB-
cord-015021-pol2qm74	5037	6	.	.	.
cord-015021-pol2qm74	5038	1	We	-PRON-	PRP
cord-015021-pol2qm74	5038	2	conclude	conclude	VBP
cord-015021-pol2qm74	5038	3	that	that	IN
cord-015021-pol2qm74	5038	4	the	the	DT
cord-015021-pol2qm74	5038	5	PAF	PAF	NNP
cord-015021-pol2qm74	5038	6	-	-	HYPH
cord-015021-pol2qm74	5038	7	evoked	evoke	VBN
cord-015021-pol2qm74	5038	8	5	5	CD
cord-015021-pol2qm74	5038	9	-	-	SYM
cord-015021-pol2qm74	5038	10	1ipoxygenase	1ipoxygenase	CD
cord-015021-pol2qm74	5038	11	product	product	NN
cord-015021-pol2qm74	5038	12	formation	formation	NN
cord-015021-pol2qm74	5038	13	in	in	IN
cord-015021-pol2qm74	5038	14	the	the	DT
cord-015021-pol2qm74	5038	15	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5038	16	-	-	HYPH
cord-015021-pol2qm74	5038	17	harbouring	harbour	VBG
cord-015021-pol2qm74	5038	18	lung	lung	NN
cord-015021-pol2qm74	5038	19	capillary	capillary	NN
cord-015021-pol2qm74	5038	20	bed	bed	NN
cord-015021-pol2qm74	5038	21	is	be	VBZ
cord-015021-pol2qm74	5038	22	critically	critically	RB
cord-015021-pol2qm74	5038	23	dependent	dependent	JJ
cord-015021-pol2qm74	5038	24	on	on	IN
cord-015021-pol2qm74	5038	25	intravascular	intravascular	JJ
cord-015021-pol2qm74	5038	26	precursor	precursor	NN
cord-015021-pol2qm74	5038	27	fatty	fatty	JJ
cord-015021-pol2qm74	5038	28	acid	acid	NN
cord-015021-pol2qm74	5038	29	supply	supply	NN
cord-015021-pol2qm74	5038	30	,	,	,
cord-015021-pol2qm74	5038	31	with	with	IN
cord-015021-pol2qm74	5038	32	EPA	EPA	NNP
cord-015021-pol2qm74	5038	33	representing	represent	VBG
cord-015021-pol2qm74	5038	34	the	the	DT
cord-015021-pol2qm74	5038	35	preferred	prefer	VBN
cord-015021-pol2qm74	5038	36	substrate	substrate	NN
cord-015021-pol2qm74	5038	37	as	as	IN
cord-015021-pol2qm74	5038	38	compared	compare	VBN
cord-015021-pol2qm74	5038	39	to	to	IN
cord-015021-pol2qm74	5038	40	AA	AA	NNP
cord-015021-pol2qm74	5038	41	.	.	.
cord-015021-pol2qm74	5039	1	PMN	pmn	NN
cord-015021-pol2qm74	5039	2	-	-	HYPH
cord-015021-pol2qm74	5039	3	related	relate	VBN
cord-015021-pol2qm74	5039	4	transcellular	transcellular	NNP
cord-015021-pol2qm74	5039	5	eicosanoid	eicosanoid	NNP
cord-015021-pol2qm74	5039	6	synthesis	synthesis	NN
cord-015021-pol2qm74	5039	7	is	be	VBZ
cord-015021-pol2qm74	5039	8	suggested	suggest	VBN
cord-015021-pol2qm74	5039	9	to	to	TO
cord-015021-pol2qm74	5039	10	underly	underly	VB
cord-015021-pol2qm74	5039	11	the	the	DT
cord-015021-pol2qm74	5039	12	predominant	predominant	JJ
cord-015021-pol2qm74	5039	13	generation	generation	NN
cord-015021-pol2qm74	5039	14	of	of	IN
cord-015021-pol2qm74	5039	15	cysteinyl	cysteinyl	NNP
cord-015021-pol2qm74	5039	16	-	-	HYPH
cord-015021-pol2qm74	5039	17	LTs	LTs	NNP
cord-015021-pol2qm74	5039	18	.	.	.
cord-015021-pol2qm74	5040	1	These	these	DT
cord-015021-pol2qm74	5040	2	findings	finding	NNS
cord-015021-pol2qm74	5040	3	may	may	MD
cord-015021-pol2qm74	5040	4	be	be	VB
cord-015021-pol2qm74	5040	5	relevant	relevant	JJ
cord-015021-pol2qm74	5040	6	for	for	IN
cord-015021-pol2qm74	5040	7	lipid	lipid	NN
cord-015021-pol2qm74	5040	8	mediator	mediator	NN
cord-015021-pol2qm74	5040	9	profiles	profile	NNS
cord-015021-pol2qm74	5040	10	provoked	provoke	VBN
cord-015021-pol2qm74	5040	11	by	by	IN
cord-015021-pol2qm74	5040	12	infusion	infusion	NN
cord-015021-pol2qm74	5040	13	of	of	IN
cord-015021-pol2qm74	5040	14	n-3-versus	n-3-versus	ADD
cord-015021-pol2qm74	5040	15	n-6enriched	n-6enriched	JJ
cord-015021-pol2qm74	5040	16	lipid	lipid	NN
cord-015021-pol2qm74	5040	17	emulsions	emulsion	NNS
cord-015021-pol2qm74	5040	18	in	in	IN
cord-015021-pol2qm74	5040	19	diseases	disease	NNS
cord-015021-pol2qm74	5040	20	with	with	IN
cord-015021-pol2qm74	5040	21	PMN	pmn	NN
cord-015021-pol2qm74	5040	22	-	-	HYPH
cord-015021-pol2qm74	5040	23	related	relate	VBN
cord-015021-pol2qm74	5040	24	inflammators	inflammator	NNS
cord-015021-pol2qm74	5040	25	events	event	NNS
cord-015021-pol2qm74	5040	26	.	.	.
cord-015021-pol2qm74	5041	1	Adult	adult	JJ
cord-015021-pol2qm74	5041	2	respiratory	respiratory	JJ
cord-015021-pol2qm74	5041	3	distress	distress	NN
cord-015021-pol2qm74	5041	4	syndrome	syndrome	NN
cord-015021-pol2qm74	5041	5	(	(	-LRB-
cord-015021-pol2qm74	5041	6	ARDS	ARDS	NNP
cord-015021-pol2qm74	5041	7	)	)	-RRB-
cord-015021-pol2qm74	5041	8	involves	involve	VBZ
cord-015021-pol2qm74	5041	9	damage	damage	NN
cord-015021-pol2qm74	5041	10	to	to	IN
cord-015021-pol2qm74	5041	11	the	the	DT
cord-015021-pol2qm74	5041	12	alveolar	alveolar	JJ
cord-015021-pol2qm74	5041	13	epithelium	epithelium	NN
cord-015021-pol2qm74	5041	14	and	and	CC
cord-015021-pol2qm74	5041	15	microvascular	microvascular	JJ
cord-015021-pol2qm74	5041	16	endothelium	endothelium	NN
cord-015021-pol2qm74	5041	17	.	.	.
cord-015021-pol2qm74	5042	1	Products	product	NNS
cord-015021-pol2qm74	5042	2	released	release	VBN
cord-015021-pol2qm74	5042	3	from	from	IN
cord-015021-pol2qm74	5042	4	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5042	5	(	(	-LRB-
cord-015021-pol2qm74	5042	6	PMN	PMN	NNP
cord-015021-pol2qm74	5042	7	)	)	-RRB-
cord-015021-pol2qm74	5042	8	are	be	VBP
cord-015021-pol2qm74	5042	9	thought	think	VBN
cord-015021-pol2qm74	5042	10	to	to	TO
cord-015021-pol2qm74	5042	11	be	be	VB
cord-015021-pol2qm74	5042	12	among	among	IN
cord-015021-pol2qm74	5042	13	the	the	DT
cord-015021-pol2qm74	5042	14	chief	chief	JJ
cord-015021-pol2qm74	5042	15	causes	cause	NNS
cord-015021-pol2qm74	5042	16	of	of	IN
cord-015021-pol2qm74	5042	17	this	this	DT
cord-015021-pol2qm74	5042	18	damage	damage	NN
cord-015021-pol2qm74	5042	19	,	,	,
cord-015021-pol2qm74	5042	20	while	while	IN
cord-015021-pol2qm74	5042	21	the	the	DT
cord-015021-pol2qm74	5042	22	role	role	NN
cord-015021-pol2qm74	5042	23	of	of	IN
cord-015021-pol2qm74	5042	24	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	5042	25	cells	cell	NNS
cord-015021-pol2qm74	5042	26	(	(	-LRB-
cord-015021-pol2qm74	5042	27	MNC	MNC	NNP
cord-015021-pol2qm74	5042	28	)	)	-RRB-
cord-015021-pol2qm74	5042	29	is	be	VBZ
cord-015021-pol2qm74	5042	30	uncertain	uncertain	JJ
cord-015021-pol2qm74	5042	31	.	.	.
cord-015021-pol2qm74	5043	1	We	-PRON-	PRP
cord-015021-pol2qm74	5043	2	studied	study	VBD
cord-015021-pol2qm74	5043	3	patients	patient	NNS
cord-015021-pol2qm74	5043	4	at	at	IN
cord-015021-pol2qm74	5043	5	risk	risk	NN
cord-015021-pol2qm74	5043	6	of	of	IN
cord-015021-pol2qm74	5043	7	or	or	CC
cord-015021-pol2qm74	5043	8	with	with	IN
cord-015021-pol2qm74	5043	9	acute	acute	JJ
cord-015021-pol2qm74	5043	10	ARDS	ARDS	NNP
cord-015021-pol2qm74	5043	11	.	.	.
cord-015021-pol2qm74	5044	1	We	-PRON-	PRP
cord-015021-pol2qm74	5044	2	measured	measure	VBD
cord-015021-pol2qm74	5044	3	the	the	DT
cord-015021-pol2qm74	5044	4	concentration	concentration	NN
cord-015021-pol2qm74	5044	5	of	of	IN
cord-015021-pol2qm74	5044	6	myeloperoxidase	myeloperoxidase	NNP
cord-015021-pol2qm74	5044	7	(	(	-LRB-
cord-015021-pol2qm74	5044	8	MPO	MPO	NNP
cord-015021-pol2qm74	5044	9	)	)	-RRB-
cord-015021-pol2qm74	5044	10	and	and	CC
cord-015021-pol2qm74	5044	11	elastase	elastase	NN
cord-015021-pol2qm74	5044	12	(	(	-LRB-
cord-015021-pol2qm74	5044	13	EL	EL	NNP
cord-015021-pol2qm74	5044	14	)	)	-RRB-
cord-015021-pol2qm74	5044	15	within	within	IN
cord-015021-pol2qm74	5044	16	circulating	circulate	VBG
cord-015021-pol2qm74	5044	17	PMN	PMN	NNP
cord-015021-pol2qm74	5044	18	as	as	IN
cord-015021-pol2qm74	5044	19	an	an	DT
cord-015021-pol2qm74	5044	20	index	index	NN
cord-015021-pol2qm74	5044	21	of	of	IN
cord-015021-pol2qm74	5044	22	PMN	PMN	NNP
cord-015021-pol2qm74	5044	23	activation	activation	NN
cord-015021-pol2qm74	5044	24	,	,	,
cord-015021-pol2qm74	5044	25	elastin	elastin	NN
cord-015021-pol2qm74	5044	26	degradation	degradation	NN
cord-015021-pol2qm74	5044	27	products	product	NNS
cord-015021-pol2qm74	5044	28	(	(	-LRB-
cord-015021-pol2qm74	5044	29	EDP	EDP	NNP
cord-015021-pol2qm74	5044	30	)	)	-RRB-
cord-015021-pol2qm74	5044	31	in	in	IN
cord-015021-pol2qm74	5044	32	the	the	DT
cord-015021-pol2qm74	5044	33	plasma	plasma	NN
cord-015021-pol2qm74	5044	34	as	as	IN
cord-015021-pol2qm74	5044	35	an	an	DT
cord-015021-pol2qm74	5044	36	index	index	NN
cord-015021-pol2qm74	5044	37	of	of	IN
cord-015021-pol2qm74	5044	38	tissue	tissue	NN
cord-015021-pol2qm74	5044	39	damage	damage	NN
cord-015021-pol2qm74	5044	40	,	,	,
cord-015021-pol2qm74	5044	41	as	as	RB
cord-015021-pol2qm74	5044	42	well	well	RB
cord-015021-pol2qm74	5044	43	as	as	IN
cord-015021-pol2qm74	5044	44	the	the	DT
cord-015021-pol2qm74	5044	45	cytotoxici	cytotoxici	NNP
cord-015021-pol2qm74	5044	46	~	~	CD
cord-015021-pol2qm74	5044	47	y	y	NNP
cord-015021-pol2qm74	5044	48	of	of	IN
cord-015021-pol2qm74	5044	49	PMN	PMN	NNP
cord-015021-pol2qm74	5044	50	and	and	CC
cord-015021-pol2qm74	5044	51	MNC	MNC	NNP
cord-015021-pol2qm74	5044	52	to	to	IN
cord-015021-pol2qm74	5044	53	endothelial	endothelial	JJ
cord-015021-pol2qm74	5044	54	cells	cell	NNS
cord-015021-pol2qm74	5044	55	(	(	-LRB-
cord-015021-pol2qm74	5044	56	EC	EC	NNP
cord-015021-pol2qm74	5044	57	)	)	-RRB-
cord-015021-pol2qm74	5044	58	in	in	IN
cord-015021-pol2qm74	5044	59	vitro	vitro	FW
cord-015021-pol2qm74	5044	60	.	.	.
cord-015021-pol2qm74	5045	1	Cells	cell	NNS
cord-015021-pol2qm74	5045	2	and	and	CC
cord-015021-pol2qm74	5045	3	plasma	plasma	NN
cord-015021-pol2qm74	5045	4	were	be	VBD
cord-015021-pol2qm74	5045	5	prepared	prepare	VBN
cord-015021-pol2qm74	5045	6	from	from	IN
cord-015021-pol2qm74	5045	7	venous	venous	JJ
cord-015021-pol2qm74	5045	8	blood	blood	NN
cord-015021-pol2qm74	5045	9	of	of	IN
cord-015021-pol2qm74	5045	10	healthy	healthy	JJ
cord-015021-pol2qm74	5045	11	controls	control	NNS
cord-015021-pol2qm74	5045	12	;	;	:
cord-015021-pol2qm74	5045	13	or	or	CC
cord-015021-pol2qm74	5045	14	systemic	systemic	JJ
cord-015021-pol2qm74	5045	15	arterial	arterial	JJ
cord-015021-pol2qm74	5045	16	blood	blood	NN
cord-015021-pol2qm74	5045	17	of	of	IN
cord-015021-pol2qm74	5045	18	patients	patient	NNS
cord-015021-pol2qm74	5045	19	on	on	IN
cord-015021-pol2qm74	5045	20	ventilators	ventilator	NNS
cord-015021-pol2qm74	5045	21	in	in	IN
cord-015021-pol2qm74	5045	22	Intensive	Intensive	NNP
cord-015021-pol2qm74	5045	23	Care	Care	NNP
cord-015021-pol2qm74	5045	24	but	but	CC
cord-015021-pol2qm74	5045	25	not	not	RB
cord-015021-pol2qm74	5045	26	at	at	IN
cord-015021-pol2qm74	5045	27	risk	risk	NN
cord-015021-pol2qm74	5045	28	of	of	IN
cord-015021-pol2qm74	5045	29	ARDS	ARDS	NNP
cord-015021-pol2qm74	5045	30	;	;	:
cord-015021-pol2qm74	5045	31	at	at	IN
cord-015021-pol2qm74	5045	32	risk	risk	NN
cord-015021-pol2qm74	5045	33	of	of	IN
cord-015021-pol2qm74	5045	34	ARDS	ARDS	NNP
cord-015021-pol2qm74	5045	35	because	because	IN
cord-015021-pol2qm74	5045	36	of	of	IN
cord-015021-pol2qm74	5045	37	sepsis	sepsis	NN
cord-015021-pol2qm74	5045	38	;	;	:
cord-015021-pol2qm74	5045	39	at	at	IN
cord-015021-pol2qm74	5045	40	risk	risk	NN
cord-015021-pol2qm74	5045	41	because	because	IN
cord-015021-pol2qm74	5045	42	of	of	IN
cord-015021-pol2qm74	5045	43	multiple	multiple	JJ
cord-015021-pol2qm74	5045	44	transfusion	transfusion	NN
cord-015021-pol2qm74	5045	45	/	/	SYM
cord-015021-pol2qm74	5045	46	major	major	JJ
cord-015021-pol2qm74	5045	47	trauma	trauma	NN
cord-015021-pol2qm74	5045	48	;	;	:
cord-015021-pol2qm74	5045	49	or	or	CC
cord-015021-pol2qm74	5045	50	with	with	IN
cord-015021-pol2qm74	5045	51	acute	acute	JJ
cord-015021-pol2qm74	5045	52	ARDS	ARDS	NNP
cord-015021-pol2qm74	5045	53	.	.	.
cord-015021-pol2qm74	5046	1	Lung	lung	NN
cord-015021-pol2qm74	5046	2	injury	injury	NN
cord-015021-pol2qm74	5046	3	,	,	,
cord-015021-pol2qm74	5046	4	multi	multi	JJ
cord-015021-pol2qm74	5046	5	-	-	JJ
cord-015021-pol2qm74	5046	6	organ	organ	JJ
cord-015021-pol2qm74	5046	7	failure	failure	NN
cord-015021-pol2qm74	5046	8	and	and	CC
cord-015021-pol2qm74	5046	9	APACHE	APACHE	NNP
cord-015021-pol2qm74	5046	10	H	h	NN
cord-015021-pol2qm74	5046	11	scores	score	NNS
cord-015021-pol2qm74	5046	12	were	be	VBD
cord-015021-pol2qm74	5046	13	recorded	record	VBN
cord-015021-pol2qm74	5046	14	.	.	.
cord-015021-pol2qm74	5047	1	To	to	TO
cord-015021-pol2qm74	5047	2	measure	measure	VB
cord-015021-pol2qm74	5047	3	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	5047	4	,	,	,
cord-015021-pol2qm74	5047	5	human	human	JJ
cord-015021-pol2qm74	5047	6	umbilical	umbilical	JJ
cord-015021-pol2qm74	5047	7	vein	vein	NN
cord-015021-pol2qm74	5047	8	EC	EC	NNP
cord-015021-pol2qm74	5047	9	were	be	VBD
cord-015021-pol2qm74	5047	10	labelled	label	VBN
cord-015021-pol2qm74	5047	11	with	with	IN
cord-015021-pol2qm74	5047	12	Cr-51	Cr-51	NNP
cord-015021-pol2qm74	5047	13	,	,	,
cord-015021-pol2qm74	5047	14	incubated	incubate	VBN
cord-015021-pol2qm74	5047	15	with	with	IN
cord-015021-pol2qm74	5047	16	either	either	CC
cord-015021-pol2qm74	5047	17	PMN	PMN	NNP
cord-015021-pol2qm74	5047	18	or	or	CC
cord-015021-pol2qm74	5047	19	MNC	MNC	NNP
cord-015021-pol2qm74	5047	20	for	for	IN
cord-015021-pol2qm74	5047	21	18	18	CD
cord-015021-pol2qm74	5047	22	hours	hour	NNS
cord-015021-pol2qm74	5047	23	,	,	,
cord-015021-pol2qm74	5047	24	and	and	CC
cord-015021-pol2qm74	5047	25	the	the	DT
cord-015021-pol2qm74	5047	26	supernatant	supernatant	NN
cord-015021-pol2qm74	5047	27	counted	count	VBD
cord-015021-pol2qm74	5047	28	.	.	.
cord-015021-pol2qm74	5048	1	The	the	DT
cord-015021-pol2qm74	5048	2	adherence	adherence	NN
cord-015021-pol2qm74	5048	3	of	of	IN
cord-015021-pol2qm74	5048	4	the	the	DT
cord-015021-pol2qm74	5048	5	PMN	PMN	NNP
cord-015021-pol2qm74	5048	6	and	and	CC
cord-015021-pol2qm74	5048	7	the	the	DT
cord-015021-pol2qm74	5048	8	MNC	MNC	NNP
cord-015021-pol2qm74	5048	9	to	to	IN
cord-015021-pol2qm74	5048	10	the	the	DT
cord-015021-pol2qm74	5048	11	EC	EC	NNP
cord-015021-pol2qm74	5048	12	was	be	VBD
cord-015021-pol2qm74	5048	13	also	also	RB
cord-015021-pol2qm74	5048	14	measured	measure	VBN
cord-015021-pol2qm74	5048	15	.	.	.
cord-015021-pol2qm74	5049	1	Standard	standard	JJ
cord-015021-pol2qm74	5049	2	assays	assay	NNS
cord-015021-pol2qm74	5049	3	were	be	VBD
cord-015021-pol2qm74	5049	4	used	use	VBN
cord-015021-pol2qm74	5049	5	to	to	TO
cord-015021-pol2qm74	5049	6	measure	measure	VB
cord-015021-pol2qm74	5049	7	MPO	MPO	NNP
cord-015021-pol2qm74	5049	8	and	and	CC
cord-015021-pol2qm74	5049	9	EL	EL	NNP
cord-015021-pol2qm74	5049	10	in	in	IN
cord-015021-pol2qm74	5049	11	the	the	DT
cord-015021-pol2qm74	5049	12	PMN	PMN	NNP
cord-015021-pol2qm74	5049	13	,	,	,
cord-015021-pol2qm74	5049	14	mad	mad	JJ
cord-015021-pol2qm74	5049	15	EDP	EDP	NNP
cord-015021-pol2qm74	5049	16	in	in	IN
cord-015021-pol2qm74	5049	17	the	the	DT
cord-015021-pol2qm74	5049	18	plasma	plasma	NN
cord-015021-pol2qm74	5049	19	.	.	.
cord-015021-pol2qm74	5050	1	The	the	DT
cord-015021-pol2qm74	5050	2	MNC	MNC	NNP
cord-015021-pol2qm74	5050	3	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	5050	4	did	do	VBD
cord-015021-pol2qm74	5050	5	not	not	RB
cord-015021-pol2qm74	5050	6	differ	differ	VB
cord-015021-pol2qm74	5050	7	between	between	IN
cord-015021-pol2qm74	5050	8	the	the	DT
cord-015021-pol2qm74	5050	9	groups	group	NNS
cord-015021-pol2qm74	5050	10	.	.	.
cord-015021-pol2qm74	5051	1	The	the	DT
cord-015021-pol2qm74	5051	2	PMN	PMN	NNP
cord-015021-pol2qm74	5051	3	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	5051	4	was	be	VBD
cord-015021-pol2qm74	5051	5	higher	high	JJR
cord-015021-pol2qm74	5051	6	in	in	IN
cord-015021-pol2qm74	5051	7	the	the	DT
cord-015021-pol2qm74	5051	8	transfusion	transfusion	NN
cord-015021-pol2qm74	5051	9	/	/	SYM
cord-015021-pol2qm74	5051	10	trauma	trauma	NN
cord-015021-pol2qm74	5051	11	patients	patient	NNS
cord-015021-pol2qm74	5051	12	compared	compare	VBN
cord-015021-pol2qm74	5051	13	to	to	IN
cord-015021-pol2qm74	5051	14	each	each	DT
cord-015021-pol2qm74	5051	15	other	other	JJ
cord-015021-pol2qm74	5051	16	group	group	NN
cord-015021-pol2qm74	5051	17	,	,	,
cord-015021-pol2qm74	5051	18	which	which	WDT
cord-015021-pol2qm74	5051	19	did	do	VBD
cord-015021-pol2qm74	5051	20	not	not	RB
cord-015021-pol2qm74	5051	21	differ	differ	VB
cord-015021-pol2qm74	5051	22	from	from	IN
cord-015021-pol2qm74	5051	23	each	each	DT
cord-015021-pol2qm74	5051	24	other	other	JJ
cord-015021-pol2qm74	5051	25	.	.	.
cord-015021-pol2qm74	5052	1	There	there	EX
cord-015021-pol2qm74	5052	2	was	be	VBD
cord-015021-pol2qm74	5052	3	no	no	DT
cord-015021-pol2qm74	5052	4	correlation	correlation	NN
cord-015021-pol2qm74	5052	5	between	between	IN
cord-015021-pol2qm74	5052	6	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	5052	7	and	and	CC
cord-015021-pol2qm74	5052	8	adherence	adherence	NN
cord-015021-pol2qm74	5052	9	for	for	IN
cord-015021-pol2qm74	5052	10	any	any	DT
cord-015021-pol2qm74	5052	11	group	group	NN
cord-015021-pol2qm74	5052	12	.	.	.
cord-015021-pol2qm74	5053	1	The	the	DT
cord-015021-pol2qm74	5053	2	MPO	MPO	NNP
cord-015021-pol2qm74	5053	3	and	and	CC
cord-015021-pol2qm74	5053	4	the	the	DT
cord-015021-pol2qm74	5053	5	EL	EL	NNP
cord-015021-pol2qm74	5053	6	concentrations	concentration	NNS
cord-015021-pol2qm74	5053	7	were	be	VBD
cord-015021-pol2qm74	5053	8	significantly	significantly	RB
cord-015021-pol2qm74	5053	9	decreased	decrease	VBN
cord-015021-pol2qm74	5053	10	in	in	IN
cord-015021-pol2qm74	5053	11	the	the	DT
cord-015021-pol2qm74	5053	12	PMN	PMN	NNP
cord-015021-pol2qm74	5053	13	from	from	IN
cord-015021-pol2qm74	5053	14	each	each	DT
cord-015021-pol2qm74	5053	15	of	of	IN
cord-015021-pol2qm74	5053	16	the	the	DT
cord-015021-pol2qm74	5053	17	patient	patient	JJ
cord-015021-pol2qm74	5053	18	groups	group	NNS
cord-015021-pol2qm74	5053	19	,	,	,
cord-015021-pol2qm74	5053	20	including	include	VBG
cord-015021-pol2qm74	5053	21	the	the	DT
cord-015021-pol2qm74	5053	22	patient	patient	NN
cord-015021-pol2qm74	5053	23	controls	control	NNS
cord-015021-pol2qm74	5053	24	,	,	,
cord-015021-pol2qm74	5053	25	compared	compare	VBN
cord-015021-pol2qm74	5053	26	to	to	IN
cord-015021-pol2qm74	5053	27	healthy	healthy	JJ
cord-015021-pol2qm74	5053	28	controls	control	NNS
cord-015021-pol2qm74	5053	29	.	.	.
cord-015021-pol2qm74	5054	1	The	the	DT
cord-015021-pol2qm74	5054	2	EDP	EDP	NNP
cord-015021-pol2qm74	5054	3	were	be	VBD
cord-015021-pol2qm74	5054	4	only	only	RB
cord-015021-pol2qm74	5054	5	increased	increase	VBN
cord-015021-pol2qm74	5054	6	in	in	IN
cord-015021-pol2qm74	5054	7	patients	patient	NNS
cord-015021-pol2qm74	5054	8	at	at	IN
cord-015021-pol2qm74	5054	9	risk	risk	NN
cord-015021-pol2qm74	5054	10	of	of	IN
cord-015021-pol2qm74	5054	11	or	or	CC
cord-015021-pol2qm74	5054	12	with	with	IN
cord-015021-pol2qm74	5054	13	ARDS	ARDS	NNP
cord-015021-pol2qm74	5054	14	.	.	.
cord-015021-pol2qm74	5055	1	Thus	thus	RB
cord-015021-pol2qm74	5055	2	PMN	PMN	NNP
cord-015021-pol2qm74	5055	3	degrannlation	degrannlation	NN
cord-015021-pol2qm74	5055	4	occurred	occur	VBD
cord-015021-pol2qm74	5055	5	in	in	IN
cord-015021-pol2qm74	5055	6	patients	patient	NNS
cord-015021-pol2qm74	5055	7	not	not	RB
cord-015021-pol2qm74	5055	8	at	at	IN
cord-015021-pol2qm74	5055	9	risk	risk	NN
cord-015021-pol2qm74	5055	10	of	of	IN
cord-015021-pol2qm74	5055	11	ARDS	ARDS	NNP
cord-015021-pol2qm74	5055	12	,	,	,
cord-015021-pol2qm74	5055	13	but	but	CC
cord-015021-pol2qm74	5055	14	tissue	tissue	NN
cord-015021-pol2qm74	5055	15	damage	damage	NN
cord-015021-pol2qm74	5055	16	as	as	IN
cord-015021-pol2qm74	5055	17	measured	measure	VBN
cord-015021-pol2qm74	5055	18	by	by	IN
cord-015021-pol2qm74	5055	19	increased	increase	VBN
cord-015021-pol2qm74	5055	20	EDP	EDP	NNP
cord-015021-pol2qm74	5055	21	only	only	RB
cord-015021-pol2qm74	5055	22	occurred	occur	VBD
cord-015021-pol2qm74	5055	23	in	in	IN
cord-015021-pol2qm74	5055	24	patients	patient	NNS
cord-015021-pol2qm74	5055	25	with	with	IN
cord-015021-pol2qm74	5055	26	or	or	CC
cord-015021-pol2qm74	5055	27	at	at	IN
cord-015021-pol2qm74	5055	28	risk	risk	NN
cord-015021-pol2qm74	5055	29	of	of	IN
cord-015021-pol2qm74	5055	30	ARDS	ARDS	NNP
cord-015021-pol2qm74	5055	31	,	,	,
cord-015021-pol2qm74	5055	32	suggesting	suggest	VBG
cord-015021-pol2qm74	5055	33	that	that	IN
cord-015021-pol2qm74	5055	34	factors	factor	NNS
cord-015021-pol2qm74	5055	35	additional	additional	JJ
cord-015021-pol2qm74	5055	36	to	to	IN
cord-015021-pol2qm74	5055	37	PMN	PMN	NNP
cord-015021-pol2qm74	5055	38	activation	activation	NN
cord-015021-pol2qm74	5055	39	and	and	CC
cord-015021-pol2qm74	5055	40	degranulation	degranulation	NN
cord-015021-pol2qm74	5055	41	are	be	VBP
cord-015021-pol2qm74	5055	42	required	require	VBN
cord-015021-pol2qm74	5055	43	for	for	IN
cord-015021-pol2qm74	5055	44	the	the	DT
cord-015021-pol2qm74	5055	45	progression	progression	NN
cord-015021-pol2qm74	5055	46	to	to	IN
cord-015021-pol2qm74	5055	47	ARDS	ARDS	NNP
cord-015021-pol2qm74	5055	48	.	.	.
cord-015021-pol2qm74	5056	1	There	there	EX
cord-015021-pol2qm74	5056	2	was	be	VBD
cord-015021-pol2qm74	5056	3	no	no	DT
cord-015021-pol2qm74	5056	4	correlation	correlation	NN
cord-015021-pol2qm74	5056	5	between	between	IN
cord-015021-pol2qm74	5056	6	the	the	DT
cord-015021-pol2qm74	5056	7	parameters	parameter	NNS
cord-015021-pol2qm74	5056	8	measured	measure	VBN
cord-015021-pol2qm74	5056	9	and	and	CC
cord-015021-pol2qm74	5056	10	the	the	DT
cord-015021-pol2qm74	5056	11	indices	index	NNS
cord-015021-pol2qm74	5056	12	of	of	IN
cord-015021-pol2qm74	5056	13	disease	disease	NN
cord-015021-pol2qm74	5056	14	activity	activity	NN
cord-015021-pol2qm74	5056	15	,	,	,
cord-015021-pol2qm74	5056	16	or	or	CC
cord-015021-pol2qm74	5056	17	outcome	outcome	NN
cord-015021-pol2qm74	5056	18	.	.	.
cord-015021-pol2qm74	5057	1	These	these	DT
cord-015021-pol2qm74	5057	2	measures	measure	NNS
cord-015021-pol2qm74	5057	3	of	of	IN
cord-015021-pol2qm74	5057	4	PMN	PMN	NNP
cord-015021-pol2qm74	5057	5	and	and	CC
cord-015021-pol2qm74	5057	6	MNC	MNC	NNP
cord-015021-pol2qm74	5057	7	activation	activation	NN
cord-015021-pol2qm74	5057	8	and	and	CC
cord-015021-pol2qm74	5057	9	function	function	NN
cord-015021-pol2qm74	5057	10	are	be	VBP
cord-015021-pol2qm74	5057	11	not	not	RB
cord-015021-pol2qm74	5057	12	of	of	IN
cord-015021-pol2qm74	5057	13	value	value	NN
cord-015021-pol2qm74	5057	14	as	as	IN
cord-015021-pol2qm74	5057	15	prognostic	prognostic	JJ
cord-015021-pol2qm74	5057	16	indicators	indicator	NNS
cord-015021-pol2qm74	5057	17	in	in	IN
cord-015021-pol2qm74	5057	18	patients	patient	NNS
cord-015021-pol2qm74	5057	19	with	with	IN
cord-015021-pol2qm74	5057	20	or	or	CC
cord-015021-pol2qm74	5057	21	at	at	IN
cord-015021-pol2qm74	5057	22	risk	risk	NN
cord-015021-pol2qm74	5057	23	of	of	IN
cord-015021-pol2qm74	5057	24	ARDS	ARDS	NNP
cord-015021-pol2qm74	5057	25	.	.	.
cord-015021-pol2qm74	5057	26	 	 	_SP
cord-015021-pol2qm74	5058	1	The	the	DT
cord-015021-pol2qm74	5058	2	liver	liver	NN
cord-015021-pol2qm74	5058	3	is	be	VBZ
cord-015021-pol2qm74	5058	4	made	make	VBN
cord-015021-pol2qm74	5058	5	up	up	RP
cord-015021-pol2qm74	5058	6	of	of	IN
cord-015021-pol2qm74	5058	7	several	several	JJ
cord-015021-pol2qm74	5058	8	different	different	JJ
cord-015021-pol2qm74	5058	9	cell	cell	NN
cord-015021-pol2qm74	5058	10	types	type	NNS
cord-015021-pol2qm74	5058	11	which	which	WDT
cord-015021-pol2qm74	5058	12	subserve	subserve	VBP
cord-015021-pol2qm74	5058	13	distinct	distinct	JJ
cord-015021-pol2qm74	5058	14	functions	function	NNS
cord-015021-pol2qm74	5058	15	in	in	IN
cord-015021-pol2qm74	5058	16	vivo	vivo	NN
cord-015021-pol2qm74	5058	17	.	.	.
cord-015021-pol2qm74	5059	1	In	in	IN
cord-015021-pol2qm74	5059	2	addition	addition	NN
cord-015021-pol2qm74	5059	3	to	to	IN
cord-015021-pol2qm74	5059	4	the	the	DT
cord-015021-pol2qm74	5059	5	different	different	JJ
cord-015021-pol2qm74	5059	6	functions	function	NNS
cord-015021-pol2qm74	5059	7	of	of	IN
cord-015021-pol2qm74	5059	8	the	the	DT
cord-015021-pol2qm74	5059	9	distinct	distinct	JJ
cord-015021-pol2qm74	5059	10	cell	cell	NN
cord-015021-pol2qm74	5059	11	types	type	NNS
cord-015021-pol2qm74	5059	12	,	,	,
cord-015021-pol2qm74	5059	13	it	-PRON-	PRP
cord-015021-pol2qm74	5059	14	is	be	VBZ
cord-015021-pol2qm74	5059	15	now	now	RB
cord-015021-pol2qm74	5059	16	evident	evident	JJ
cord-015021-pol2qm74	5059	17	that	that	IN
cord-015021-pol2qm74	5059	18	even	even	RB
cord-015021-pol2qm74	5059	19	within	within	IN
cord-015021-pol2qm74	5059	20	the	the	DT
cord-015021-pol2qm74	5059	21	population	population	NN
cord-015021-pol2qm74	5059	22	of	of	IN
cord-015021-pol2qm74	5059	23	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5059	24	substantial	substantial	JJ
cord-015021-pol2qm74	5059	25	functional	functional	JJ
cord-015021-pol2qm74	5059	26	heterogeneity	heterogeneity	NN
cord-015021-pol2qm74	5059	27	exists	exist	VBZ
cord-015021-pol2qm74	5059	28	.	.	.
cord-015021-pol2qm74	5060	1	This	this	DT
cord-015021-pol2qm74	5060	2	heterogeneity	heterogeneity	NN
cord-015021-pol2qm74	5060	3	occurs	occur	VBZ
cord-015021-pol2qm74	5060	4	in	in	IN
cord-015021-pol2qm74	5060	5	a	a	DT
cord-015021-pol2qm74	5060	6	very	very	RB
cord-015021-pol2qm74	5060	7	organized	organized	JJ
cord-015021-pol2qm74	5060	8	fashion	fashion	NN
cord-015021-pol2qm74	5060	9	in	in	IN
cord-015021-pol2qm74	5060	10	the	the	DT
cord-015021-pol2qm74	5060	11	normal	normal	JJ
cord-015021-pol2qm74	5060	12	liver	liver	NN
cord-015021-pol2qm74	5060	13	based	base	VBN
cord-015021-pol2qm74	5060	14	upon	upon	IN
cord-015021-pol2qm74	5060	15	the	the	DT
cord-015021-pol2qm74	5060	16	position	position	NN
cord-015021-pol2qm74	5060	17	of	of	IN
cord-015021-pol2qm74	5060	18	the	the	DT
cord-015021-pol2qm74	5060	19	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	5060	20	in	in	IN
cord-015021-pol2qm74	5060	21	the	the	DT
cord-015021-pol2qm74	5060	22	acinus	acinus	NN
cord-015021-pol2qm74	5060	23	.	.	.
cord-015021-pol2qm74	5061	1	Although	although	IN
cord-015021-pol2qm74	5061	2	it	-PRON-	PRP
cord-015021-pol2qm74	5061	3	has	have	VBZ
cord-015021-pol2qm74	5061	4	been	be	VBN
cord-015021-pol2qm74	5061	5	proposed	propose	VBN
cord-015021-pol2qm74	5061	6	that	that	IN
cord-015021-pol2qm74	5061	7	the	the	DT
cord-015021-pol2qm74	5061	8	acinar	acinar	JJ
cord-015021-pol2qm74	5061	9	heterogeneity	heterogeneity	NN
cord-015021-pol2qm74	5061	10	of	of	IN
cord-015021-pol2qm74	5061	11	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5061	12	arises	arise	VBZ
cord-015021-pol2qm74	5061	13	from	from	IN
cord-015021-pol2qm74	5061	14	migration	migration	NN
cord-015021-pol2qm74	5061	15	of	of	IN
cord-015021-pol2qm74	5061	16	immature	immature	JJ
cord-015021-pol2qm74	5061	17	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5061	18	from	from	IN
cord-015021-pol2qm74	5061	19	the	the	DT
cord-015021-pol2qm74	5061	20	periportal	periportal	JJ
cord-015021-pol2qm74	5061	21	region	region	NN
cord-015021-pol2qm74	5061	22	to	to	IN
cord-015021-pol2qm74	5061	23	the	the	DT
cord-015021-pol2qm74	5061	24	perivenous	perivenous	NNP
cord-015021-pol2qm74	5061	25	region	region	NN
cord-015021-pol2qm74	5061	26	where	where	WRB
cord-015021-pol2qm74	5061	27	they	-PRON-	PRP
cord-015021-pol2qm74	5061	28	become	become	VBP
cord-015021-pol2qm74	5061	29	senescent	senescent	JJ
cord-015021-pol2qm74	5061	30	and	and	CC
cord-015021-pol2qm74	5061	31	die	die	VB
cord-015021-pol2qm74	5061	32	,	,	,
cord-015021-pol2qm74	5061	33	many	many	JJ
cord-015021-pol2qm74	5061	34	of	of	IN
cord-015021-pol2qm74	5061	35	the	the	DT
cord-015021-pol2qm74	5061	36	heterogeneous	heterogeneous	JJ
cord-015021-pol2qm74	5061	37	responses	response	NNS
cord-015021-pol2qm74	5061	38	can	can	MD
cord-015021-pol2qm74	5061	39	be	be	VB
cord-015021-pol2qm74	5061	40	accutely	accutely	RB
cord-015021-pol2qm74	5061	41	reversed	reverse	VBN
cord-015021-pol2qm74	5061	42	by	by	IN
cord-015021-pol2qm74	5061	43	reversal	reversal	NN
cord-015021-pol2qm74	5061	44	of	of	IN
cord-015021-pol2qm74	5061	45	the	the	DT
cord-015021-pol2qm74	5061	46	oxygen	oxygen	NN
cord-015021-pol2qm74	5061	47	gradient	gradient	NN
cord-015021-pol2qm74	5061	48	via	via	IN
cord-015021-pol2qm74	5061	49	retrograde	retrograde	JJ
cord-015021-pol2qm74	5061	50	perfusion	perfusion	NN
cord-015021-pol2qm74	5061	51	.	.	.
cord-015021-pol2qm74	5062	1	Under	under	IN
cord-015021-pol2qm74	5062	2	normal	normal	JJ
cord-015021-pol2qm74	5062	3	conditions	condition	NNS
cord-015021-pol2qm74	5062	4	in	in	IN
cord-015021-pol2qm74	5062	5	which	which	WDT
cord-015021-pol2qm74	5062	6	the	the	DT
cord-015021-pol2qm74	5062	7	acinus	acinus	NNP
cord-015021-pol2qm74	5062	8	is	be	VBZ
cord-015021-pol2qm74	5062	9	exposed	expose	VBN
cord-015021-pol2qm74	5062	10	to	to	IN
cord-015021-pol2qm74	5062	11	unidirectional	unidirectional	JJ
cord-015021-pol2qm74	5062	12	flow	flow	NN
cord-015021-pol2qm74	5062	13	,	,	,
cord-015021-pol2qm74	5062	14	the	the	DT
cord-015021-pol2qm74	5062	15	periportal	periportal	JJ
cord-015021-pol2qm74	5062	16	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5062	17	are	be	VBP
cord-015021-pol2qm74	5062	18	exposed	expose	VBN
cord-015021-pol2qm74	5062	19	to	to	IN
cord-015021-pol2qm74	5062	20	relatively	relatively	RB
cord-015021-pol2qm74	5062	21	high	high	JJ
cord-015021-pol2qm74	5062	22	levels	level	NNS
cord-015021-pol2qm74	5062	23	of	of	IN
cord-015021-pol2qm74	5062	24	oxygen	oxygen	NN
cord-015021-pol2qm74	5062	25	,	,	,
cord-015021-pol2qm74	5062	26	substrates	substrate	NNS
cord-015021-pol2qm74	5062	27	and	and	CC
cord-015021-pol2qm74	5062	28	hormones	hormone	NNS
cord-015021-pol2qm74	5062	29	.	.	.
cord-015021-pol2qm74	5063	1	As	as	IN
cord-015021-pol2qm74	5063	2	these	these	DT
cord-015021-pol2qm74	5063	3	substances	substance	NNS
cord-015021-pol2qm74	5063	4	are	be	VBP
cord-015021-pol2qm74	5063	5	extracted	extract	VBN
cord-015021-pol2qm74	5063	6	along	along	IN
cord-015021-pol2qm74	5063	7	the	the	DT
cord-015021-pol2qm74	5063	8	aeinus	aeinus	NN
cord-015021-pol2qm74	5063	9	their	-PRON-	PRP$
cord-015021-pol2qm74	5063	10	concentration	concentration	NN
cord-015021-pol2qm74	5063	11	decreases	decrease	VBZ
cord-015021-pol2qm74	5063	12	leaving	leave	VBG
cord-015021-pol2qm74	5063	13	relatively	relatively	RB
cord-015021-pol2qm74	5063	14	low	low	JJ
cord-015021-pol2qm74	5063	15	concentrations	concentration	NNS
cord-015021-pol2qm74	5063	16	for	for	IN
cord-015021-pol2qm74	5063	17	the	the	DT
cord-015021-pol2qm74	5063	18	perivenous	perivenous	NNP
cord-015021-pol2qm74	5063	19	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5063	20	.	.	.
cord-015021-pol2qm74	5064	1	In	in	IN
cord-015021-pol2qm74	5064	2	the	the	DT
cord-015021-pol2qm74	5064	3	normal	normal	JJ
cord-015021-pol2qm74	5064	4	liver	liver	NN
cord-015021-pol2qm74	5064	5	,	,	,
cord-015021-pol2qm74	5064	6	the	the	DT
cord-015021-pol2qm74	5064	7	heterogeneity	heterogeneity	NN
cord-015021-pol2qm74	5064	8	of	of	IN
cord-015021-pol2qm74	5064	9	response	response	NN
cord-015021-pol2qm74	5064	10	is	be	VBZ
cord-015021-pol2qm74	5064	11	attenuated	attenuate	VBN
cord-015021-pol2qm74	5064	12	by	by	IN
cord-015021-pol2qm74	5064	13	extensive	extensive	JJ
cord-015021-pol2qm74	5064	14	communication	communication	NN
cord-015021-pol2qm74	5064	15	via	via	IN
cord-015021-pol2qm74	5064	16	gap	gap	NN
cord-015021-pol2qm74	5064	17	junctions	junction	NNS
cord-015021-pol2qm74	5064	18	.	.	.
cord-015021-pol2qm74	5065	1	The	the	DT
cord-015021-pol2qm74	5065	2	major	major	JJ
cord-015021-pol2qm74	5065	3	liver	liver	NN
cord-015021-pol2qm74	5065	4	gap	gap	NN
cord-015021-pol2qm74	5065	5	junctions	junction	NNS
cord-015021-pol2qm74	5065	6	are	be	VBP
cord-015021-pol2qm74	5065	7	made	make	VBN
cord-015021-pol2qm74	5065	8	up	up	RP
cord-015021-pol2qm74	5065	9	of	of	IN
cord-015021-pol2qm74	5065	10	hexamers	hexamer	NNS
cord-015021-pol2qm74	5065	11	of	of	IN
cord-015021-pol2qm74	5065	12	connexin	connexin	NNP
cord-015021-pol2qm74	5065	13	32	32	CD
cord-015021-pol2qm74	5065	14	(	(	-LRB-
cord-015021-pol2qm74	5065	15	Cx32	Cx32	NNP
cord-015021-pol2qm74	5065	16	)	)	-RRB-
cord-015021-pol2qm74	5065	17	which	which	WDT
cord-015021-pol2qm74	5065	18	forms	form	VBZ
cord-015021-pol2qm74	5065	19	channels	channel	NNS
cord-015021-pol2qm74	5065	20	between	between	IN
cord-015021-pol2qm74	5065	21	cells	cell	NNS
cord-015021-pol2qm74	5065	22	capable	capable	JJ
cord-015021-pol2qm74	5065	23	of	of	IN
cord-015021-pol2qm74	5065	24	pas.~ing	pas.~e	VBG
cord-015021-pol2qm74	5065	25	any	any	DT
cord-015021-pol2qm74	5065	26	molecule	molecule	NN
cord-015021-pol2qm74	5065	27	smaller	small	JJR
cord-015021-pol2qm74	5065	28	than	than	IN
cord-015021-pol2qm74	5065	29	1000	1000	CD
cord-015021-pol2qm74	5065	30	D.	D.	NNP
cord-015021-pol2qm74	5065	31	Coupling	Coupling	NNP
cord-015021-pol2qm74	5065	32	is	be	VBZ
cord-015021-pol2qm74	5065	33	sufficient	sufficient	JJ
cord-015021-pol2qm74	5065	34	to	to	TO
cord-015021-pol2qm74	5065	35	allow	allow	VB
cord-015021-pol2qm74	5065	36	diffusion	diffusion	NN
cord-015021-pol2qm74	5065	37	of	of	IN
cord-015021-pol2qm74	5065	38	molecules	molecule	NNS
cord-015021-pol2qm74	5065	39	such	such	JJ
cord-015021-pol2qm74	5065	40	as	as	IN
cord-015021-pol2qm74	5065	41	ATP	ATP	NNP
cord-015021-pol2qm74	5065	42	or	or	CC
cord-015021-pol2qm74	5065	43	cAMP	cAMP	VBZ
cord-015021-pol2qm74	5065	44	from	from	IN
cord-015021-pol2qm74	5065	45	one	one	CD
cord-015021-pol2qm74	5065	46	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	5065	47	into	into	IN
cord-015021-pol2qm74	5065	48	>	>	$
cord-015021-pol2qm74	5065	49	20	20	CD
cord-015021-pol2qm74	5065	50	adjacent	adjacent	JJ
cord-015021-pol2qm74	5065	51	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5065	52	within	within	IN
cord-015021-pol2qm74	5065	53	60	60	CD
cord-015021-pol2qm74	5065	54	seconds	second	NNS
cord-015021-pol2qm74	5065	55	.	.	.
cord-015021-pol2qm74	5066	1	During	during	IN
cord-015021-pol2qm74	5066	2	stress	stress	NN
cord-015021-pol2qm74	5066	3	conditions	condition	NNS
cord-015021-pol2qm74	5066	4	such	such	JJ
cord-015021-pol2qm74	5066	5	as	as	IN
cord-015021-pol2qm74	5066	6	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	5066	7	or	or	CC
cord-015021-pol2qm74	5066	8	zymozan	zymozan	NN
cord-015021-pol2qm74	5066	9	inflammation	inflammation	NN
cord-015021-pol2qm74	5066	10	,	,	,
cord-015021-pol2qm74	5066	11	expression	expression	NN
cord-015021-pol2qm74	5066	12	of	of	IN
cord-015021-pol2qm74	5066	13	Cx32	Cx32	NNP
cord-015021-pol2qm74	5066	14	is	be	VBZ
cord-015021-pol2qm74	5066	15	markedly	markedly	RB
cord-015021-pol2qm74	5066	16	decreased	decrease	VBN
cord-015021-pol2qm74	5066	17	while	while	IN
cord-015021-pol2qm74	5066	18	the	the	DT
cord-015021-pol2qm74	5066	19	secondary	secondary	JJ
cord-015021-pol2qm74	5066	20	gap	gap	NN
cord-015021-pol2qm74	5066	21	junction	junction	NN
cord-015021-pol2qm74	5066	22	protein	protein	NN
cord-015021-pol2qm74	5066	23	Cx26	Cx26	NNP
cord-015021-pol2qm74	5066	24	is	be	VBZ
cord-015021-pol2qm74	5066	25	either	either	CC
cord-015021-pol2qm74	5066	26	unchanged	unchanged	JJ
cord-015021-pol2qm74	5066	27	or	or	CC
cord-015021-pol2qm74	5066	28	even	even	RB
cord-015021-pol2qm74	5066	29	increased	increase	VBN
cord-015021-pol2qm74	5066	30	.	.	.
cord-015021-pol2qm74	5067	1	While	while	IN
cord-015021-pol2qm74	5067	2	Cx	Cx	NNP
cord-015021-pol2qm74	5067	3	26	26	CD
cord-015021-pol2qm74	5067	4	readily	readily	RB
cord-015021-pol2qm74	5067	5	effects	effect	VBZ
cord-015021-pol2qm74	5067	6	electrical	electrical	JJ
cord-015021-pol2qm74	5067	7	coupling	coupling	NN
cord-015021-pol2qm74	5067	8	,	,	,
cord-015021-pol2qm74	5067	9	molecules	molecule	NNS
cord-015021-pol2qm74	5067	10	>	>	XX
cord-015021-pol2qm74	5067	11	350	350	CD
cord-015021-pol2qm74	5067	12	D	d	NN
cord-015021-pol2qm74	5067	13	pass	pass	NN
cord-015021-pol2qm74	5067	14	only	only	RB
cord-015021-pol2qm74	5067	15	very	very	RB
cord-015021-pol2qm74	5067	16	slowly	slowly	RB
cord-015021-pol2qm74	5067	17	.	.	.
cord-015021-pol2qm74	5068	1	This	this	DT
cord-015021-pol2qm74	5068	2	would	would	MD
cord-015021-pol2qm74	5068	3	result	result	VB
cord-015021-pol2qm74	5068	4	in	in	IN
cord-015021-pol2qm74	5068	5	restriciton	restriciton	NN
cord-015021-pol2qm74	5068	6	of	of	IN
cord-015021-pol2qm74	5068	7	transmission	transmission	NN
cord-015021-pol2qm74	5068	8	of	of	IN
cord-015021-pol2qm74	5068	9	moecules	moecule	NNS
cord-015021-pol2qm74	5068	10	the	the	DT
cord-015021-pol2qm74	5068	11	size	size	NN
cord-015021-pol2qm74	5068	12	of	of	IN
cord-015021-pol2qm74	5068	13	ATP	ATP	NNP
cord-015021-pol2qm74	5068	14	or	or	CC
cord-015021-pol2qm74	5068	15	cAMP	camp	NN
cord-015021-pol2qm74	5068	16	.	.	.
cord-015021-pol2qm74	5069	1	Since	since	IN
cord-015021-pol2qm74	5069	2	inhibition	inhibition	NN
cord-015021-pol2qm74	5069	3	of	of	IN
cord-015021-pol2qm74	5069	4	gap	gap	NN
cord-015021-pol2qm74	5069	5	junctions	junction	NNS
cord-015021-pol2qm74	5069	6	also	also	RB
cord-015021-pol2qm74	5069	7	attentuates	attentuate	VBZ
cord-015021-pol2qm74	5069	8	metabolic	metabolic	JJ
cord-015021-pol2qm74	5069	9	response	response	NN
cord-015021-pol2qm74	5069	10	to	to	IN
cord-015021-pol2qm74	5069	11	hormone	hormone	NN
cord-015021-pol2qm74	5069	12	or	or	CC
cord-015021-pol2qm74	5069	13	nerve	nerve	NN
cord-015021-pol2qm74	5069	14	stimulation	stimulation	NN
cord-015021-pol2qm74	5069	15	,	,	,
cord-015021-pol2qm74	5069	16	it	-PRON-	PRP
cord-015021-pol2qm74	5069	17	is	be	VBZ
cord-015021-pol2qm74	5069	18	evident	evident	JJ
cord-015021-pol2qm74	5069	19	that	that	IN
cord-015021-pol2qm74	5069	20	modulation	modulation	NN
cord-015021-pol2qm74	5069	21	of	of	IN
cord-015021-pol2qm74	5069	22	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	5069	23	hetereogeneity	hetereogeneity	NN
cord-015021-pol2qm74	5069	24	by	by	IN
cord-015021-pol2qm74	5069	25	gap	gap	NN
cord-015021-pol2qm74	5069	26	junctions	junction	NNS
cord-015021-pol2qm74	5069	27	must	must	MD
cord-015021-pol2qm74	5069	28	be	be	VB
cord-015021-pol2qm74	5069	29	considered	consider	VBN
cord-015021-pol2qm74	5069	30	in	in	IN
cord-015021-pol2qm74	5069	31	determining	determine	VBG
cord-015021-pol2qm74	5069	32	the	the	DT
cord-015021-pol2qm74	5069	33	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5069	34	of	of	IN
cord-015021-pol2qm74	5069	35	metabolic	metabolic	JJ
cord-015021-pol2qm74	5069	36	alterations	alteration	NNS
cord-015021-pol2qm74	5069	37	during	during	IN
cord-015021-pol2qm74	5069	38	stress	stress	NN
cord-015021-pol2qm74	5069	39	.	.	.
cord-015021-pol2qm74	5069	40	 	 	_SP
cord-015021-pol2qm74	5070	1	Already	already	RB
cord-015021-pol2qm74	5070	2	minor	minor	JJ
cord-015021-pol2qm74	5070	3	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	5070	4	decreases	decrease	VBZ
cord-015021-pol2qm74	5070	5	portal	portal	JJ
cord-015021-pol2qm74	5070	6	venous	venous	JJ
cord-015021-pol2qm74	5070	7	blood	blood	NN
cord-015021-pol2qm74	5070	8	supply	supply	NN
cord-015021-pol2qm74	5070	9	to	to	IN
cord-015021-pol2qm74	5070	10	the	the	DT
cord-015021-pol2qm74	5070	11	fiver	fiver	NN
cord-015021-pol2qm74	5070	12	and	and	CC
cord-015021-pol2qm74	5070	13	the	the	DT
cord-015021-pol2qm74	5070	14	reduction	reduction	NN
cord-015021-pol2qm74	5070	15	in	in	IN
cord-015021-pol2qm74	5070	16	portal	portal	JJ
cord-015021-pol2qm74	5070	17	blood	blood	NN
cord-015021-pol2qm74	5070	18	flow	flow	NN
cord-015021-pol2qm74	5070	19	becomes	become	VBZ
cord-015021-pol2qm74	5070	20	more	more	RBR
cord-015021-pol2qm74	5070	21	pronounced	pronounced	JJ
cord-015021-pol2qm74	5070	22	with	with	IN
cord-015021-pol2qm74	5070	23	more	more	RBR
cord-015021-pol2qm74	5070	24	profound	profound	JJ
cord-015021-pol2qm74	5070	25	btood	btood	NN
cord-015021-pol2qm74	5070	26	loss	loss	NN
cord-015021-pol2qm74	5070	27	.	.	.
cord-015021-pol2qm74	5071	1	Severe	severe	JJ
cord-015021-pol2qm74	5071	2	hacmorrhagic	hacmorrhagic	NNP
cord-015021-pol2qm74	5071	3	hypovolemia	hypovolemia	NN
cord-015021-pol2qm74	5071	4	also	also	RB
cord-015021-pol2qm74	5071	5	reduces	reduce	VBZ
cord-015021-pol2qm74	5071	6	hepatic	hepatic	JJ
cord-015021-pol2qm74	5071	7	arterial	arterial	JJ
cord-015021-pol2qm74	5071	8	blood	blood	NN
cord-015021-pol2qm74	5071	9	supply	supply	NN
cord-015021-pol2qm74	5071	10	which	which	WDT
cord-015021-pol2qm74	5071	11	,	,	,
cord-015021-pol2qm74	5071	12	however	however	RB
cord-015021-pol2qm74	5071	13	,	,	,
cord-015021-pol2qm74	5071	14	is	be	VBZ
cord-015021-pol2qm74	5071	15	maintained	maintain	VBN
cord-015021-pol2qm74	5071	16	over	over	IN
cord-015021-pol2qm74	5071	17	a	a	DT
cord-015021-pol2qm74	5071	18	vide	vide	NN
cord-015021-pol2qm74	5071	19	range	range	NN
cord-015021-pol2qm74	5071	20	of	of	IN
cord-015021-pol2qm74	5071	21	haemorthage	haemorthage	NN
cord-015021-pol2qm74	5071	22	.	.	.
cord-015021-pol2qm74	5072	1	The	the	DT
cord-015021-pol2qm74	5072	2	net	net	JJ
cord-015021-pol2qm74	5072	3	effect	effect	NN
cord-015021-pol2qm74	5072	4	of	of	IN
cord-015021-pol2qm74	5072	5	blood	blood	NN
cord-015021-pol2qm74	5072	6	loss	loss	NN
cord-015021-pol2qm74	5072	7	is	be	VBZ
cord-015021-pol2qm74	5072	8	a	a	DT
cord-015021-pol2qm74	5072	9	reduction	reduction	NN
cord-015021-pol2qm74	5072	10	in	in	IN
cord-015021-pol2qm74	5072	11	liver	liver	NN
cord-015021-pol2qm74	5072	12	oxygee	oxygee	NN
cord-015021-pol2qm74	5072	13	supply	supply	NN
cord-015021-pol2qm74	5072	14	and	and	CC
cord-015021-pol2qm74	5072	15	this	this	DT
cord-015021-pol2qm74	5072	16	reduction	reduction	NN
cord-015021-pol2qm74	5072	17	is	be	VBZ
cord-015021-pol2qm74	5072	18	in	in	IN
cord-015021-pol2qm74	5072	19	proportion	proportion	NN
cord-015021-pol2qm74	5072	20	to	to	IN
cord-015021-pol2qm74	5072	21	the	the	DT
cord-015021-pol2qm74	5072	22	vulume	vulume	NN
cord-015021-pol2qm74	5072	23	Iossed	Iossed	NNP
cord-015021-pol2qm74	5072	24	.	.	.
cord-015021-pol2qm74	5073	1	However	however	RB
cord-015021-pol2qm74	5073	2	,	,	,
cord-015021-pol2qm74	5073	3	oxygen	oxygen	NN
cord-015021-pol2qm74	5073	4	supply	supply	NN
cord-015021-pol2qm74	5073	5	to	to	IN
cord-015021-pol2qm74	5073	6	the	the	DT
cord-015021-pol2qm74	5073	7	liver	liver	NN
cord-015021-pol2qm74	5073	8	exceeds	exceed	VBZ
cord-015021-pol2qm74	5073	9	the	the	DT
cord-015021-pol2qm74	5073	10	demands	demand	NNS
cord-015021-pol2qm74	5073	11	of	of	IN
cord-015021-pol2qm74	5073	12	the	the	DT
cord-015021-pol2qm74	5073	13	normal	normal	JJ
cord-015021-pol2qm74	5073	14	liver	liver	NN
cord-015021-pol2qm74	5073	15	and	and	CC
cord-015021-pol2qm74	5073	16	this	this	DT
cord-015021-pol2qm74	5073	17	is	be	VBZ
cord-015021-pol2qm74	5073	18	the	the	DT
cord-015021-pol2qm74	5073	19	ca~	ca~	NN
cord-015021-pol2qm74	5073	20	stilt	stilt	NN
cord-015021-pol2qm74	5073	21	following	follow	VBG
cord-015021-pol2qm74	5073	22	reduction	reduction	NN
cord-015021-pol2qm74	5073	23	of	of	IN
cord-015021-pol2qm74	5073	24	30	30	CD
cord-015021-pol2qm74	5073	25	%	%	NN
cord-015021-pol2qm74	5073	26	of	of	IN
cord-015021-pol2qm74	5073	27	blood	blood	NN
cord-015021-pol2qm74	5073	28	volume	volume	NN
cord-015021-pol2qm74	5073	29	.	.	.
cord-015021-pol2qm74	5074	1	The	the	DT
cord-015021-pol2qm74	5074	2	situation	situation	NN
cord-015021-pol2qm74	5074	3	in	in	IN
cord-015021-pol2qm74	5074	4	sepsis	sepsis	NN
cord-015021-pol2qm74	5074	5	is	be	VBZ
cord-015021-pol2qm74	5074	6	more	more	RBR
cord-015021-pol2qm74	5074	7	complicated	complicated	JJ
cord-015021-pol2qm74	5074	8	.	.	.
cord-015021-pol2qm74	5075	1	Po	Po	NNP
cord-015021-pol2qm74	5076	1	~l	~l	NNP
cord-015021-pol2qm74	5076	2	venous	venous	JJ
cord-015021-pol2qm74	5076	3	supply	supply	NN
cord-015021-pol2qm74	5076	4	to	to	IN
cord-015021-pol2qm74	5076	5	the	the	DT
cord-015021-pol2qm74	5076	6	liver	liver	NN
cord-015021-pol2qm74	5076	7	is	be	VBZ
cord-015021-pol2qm74	5076	8	redur.~i	redur.~i	NNS
cord-015021-pol2qm74	5076	9	fairly	fairly	RB
cord-015021-pol2qm74	5076	10	early	early	RB
cord-015021-pol2qm74	5076	11	following	follow	VBG
cord-015021-pol2qm74	5076	12	normovolemic	normovolemic	JJ
cord-015021-pol2qm74	5076	13	sepsis	sepsis	NN
cord-015021-pol2qm74	5076	14	while	while	IN
cord-015021-pol2qm74	5076	15	hepatic	hepatic	JJ
cord-015021-pol2qm74	5076	16	arterial	arterial	JJ
cord-015021-pol2qm74	5076	17	blood	blood	NN
cord-015021-pol2qm74	5076	18	supply	supply	NN
cord-015021-pol2qm74	5076	19	is	be	VBZ
cord-015021-pol2qm74	5076	20	maintained	maintain	VBN
cord-015021-pol2qm74	5076	21	at	at	IN
cord-015021-pol2qm74	5076	22	le,~t	le,~t	NNP
cord-015021-pol2qm74	5076	23	initialIy	initialIy	NNP
cord-015021-pol2qm74	5076	24	,	,	,
cord-015021-pol2qm74	5076	25	Oxygen	oxygen	NN
cord-015021-pol2qm74	5076	26	saturation	saturation	NN
cord-015021-pol2qm74	5076	27	might	may	MD
cord-015021-pol2qm74	5076	28	be	be	VB
cord-015021-pol2qm74	5076	29	maintained	maintain	VBN
cord-015021-pol2qm74	5076	30	in	in	IN
cord-015021-pol2qm74	5076	31	arterial	arterial	JJ
cord-015021-pol2qm74	5076	32	blood	blood	NN
cord-015021-pol2qm74	5076	33	but	but	CC
cord-015021-pol2qm74	5076	34	may	may	MD
cord-015021-pol2qm74	5076	35	also	also	RB
cord-015021-pol2qm74	5076	36	be	be	VB
cord-015021-pol2qm74	5076	37	slightly	slightly	RB
cord-015021-pol2qm74	5076	38	reduced	reduce	VBN
cord-015021-pol2qm74	5076	39	during	during	IN
cord-015021-pol2qm74	5076	40	sepsis	sepsis	NN
cord-015021-pol2qm74	5076	41	,	,	,
cord-015021-pol2qm74	5076	42	Oxygen	oxygen	NN
cord-015021-pol2qm74	5076	43	saturation	saturation	NN
cord-015021-pol2qm74	5076	44	of	of	IN
cord-015021-pol2qm74	5076	45	portal	portal	JJ
cord-015021-pol2qm74	5076	46	venous	venous	JJ
cord-015021-pol2qm74	5076	47	blood	blood	NN
cord-015021-pol2qm74	5076	48	is	be	VBZ
cord-015021-pol2qm74	5076	49	significantly	significantly	RB
cord-015021-pol2qm74	5076	50	reduced	reduce	VBN
cord-015021-pol2qm74	5076	51	during	during	IN
cord-015021-pol2qm74	5076	52	sepsis	sepsis	NN
cord-015021-pol2qm74	5076	53	due	due	IN
cord-015021-pol2qm74	5076	54	to	to	IN
cord-015021-pol2qm74	5076	55	increased	increase	VBN
cord-015021-pol2qm74	5076	56	extraction	extraction	NN
cord-015021-pol2qm74	5076	57	of	of	IN
cord-015021-pol2qm74	5076	58	the	the	DT
cord-015021-pol2qm74	5076	59	intestines	intestine	NNS
cord-015021-pol2qm74	5076	60	.	.	.
cord-015021-pol2qm74	5077	1	Therefore	therefore	RB
cord-015021-pol2qm74	5077	2	oxygea	oxygea	VB
cord-015021-pol2qm74	5077	3	delivery	delivery	NN
cord-015021-pol2qm74	5077	4	to	to	IN
cord-015021-pol2qm74	5077	5	the	the	DT
cord-015021-pol2qm74	5077	6	liver	liver	NN
cord-015021-pol2qm74	5077	7	during	during	IN
cord-015021-pol2qm74	5077	8	sepsis	sepsis	NN
cord-015021-pol2qm74	5077	9	becomes	become	VBZ
cord-015021-pol2qm74	5077	10	sigalfkzntly	sigalfkzntly	RB
cord-015021-pol2qm74	5077	11	reduced	reduce	VBN
cord-015021-pol2qm74	5077	12	.	.	.
cord-015021-pol2qm74	5078	1	At	at	IN
cord-015021-pol2qm74	5078	2	the	the	DT
cord-015021-pol2qm74	5078	3	s,~ne	s,~ne	NNP
cord-015021-pol2qm74	5078	4	time	time	NN
cord-015021-pol2qm74	5078	5	and	and	CC
cord-015021-pol2qm74	5078	6	for	for	IN
cord-015021-pol2qm74	5078	7	mai.v.ly	mai.v.ly	DT
cord-015021-pol2qm74	5078	8	unknown	unknown	JJ
cord-015021-pol2qm74	5078	9	reasons	reason	NNS
cord-015021-pol2qm74	5078	10	the	the	DT
cord-015021-pol2qm74	5078	11	need	need	NN
cord-015021-pol2qm74	5078	12	for	for	IN
cord-015021-pol2qm74	5078	13	oxygen	oxygen	NN
cord-015021-pol2qm74	5078	14	becomes	become	VBZ
cord-015021-pol2qm74	5078	15	significantly	significantly	RB
cord-015021-pol2qm74	5078	16	increased	increase	VBN
cord-015021-pol2qm74	5078	17	in	in	IN
cord-015021-pol2qm74	5078	18	the	the	DT
cord-015021-pol2qm74	5078	19	~-~ptic	~-~ptic	JJ
cord-015021-pol2qm74	5078	20	liver	liver	NN
cord-015021-pol2qm74	5078	21	.	.	.
cord-015021-pol2qm74	5079	1	As	as	IN
cord-015021-pol2qm74	5079	2	a	a	DT
cord-015021-pol2qm74	5079	3	consequence	consequence	NN
cord-015021-pol2qm74	5079	4	liver	liver	NN
cord-015021-pol2qm74	5079	5	oxygen	oxygen	NN
cord-015021-pol2qm74	5079	6	consumption	consumption	NN
cord-015021-pol2qm74	5079	7	becomes	become	VBZ
cord-015021-pol2qm74	5079	8	flow	flow	NN
cord-015021-pol2qm74	5079	9	dependent	dependent	JJ
cord-015021-pol2qm74	5079	10	and	and	CC
cord-015021-pol2qm74	5079	11	the	the	DT
cord-015021-pol2qm74	5079	12	liver	liver	NN
cord-015021-pol2qm74	5079	13	is	be	VBZ
cord-015021-pol2qm74	5079	14	likely	likely	JJ
cord-015021-pol2qm74	5079	15	to	to	TO
cord-015021-pol2qm74	5079	16	suffer	suffer	VB
cord-015021-pol2qm74	5079	17	from	from	IN
cord-015021-pol2qm74	5079	18	ischemia	ischemia	NN
cord-015021-pol2qm74	5079	19	during	during	IN
cord-015021-pol2qm74	5079	20	septic	septic	JJ
cord-015021-pol2qm74	5079	21	conditions	condition	NNS
cord-015021-pol2qm74	5079	22	.	.	.
cord-015021-pol2qm74	5080	1	$	$	$
cord-015021-pol2qm74	5080	2	94	94	CD
cord-015021-pol2qm74	5081	1	Although	although	IN
cord-015021-pol2qm74	5081	2	liver	liver	NN
cord-015021-pol2qm74	5081	3	failure	failure	NN
cord-015021-pol2qm74	5081	4	is	be	VBZ
cord-015021-pol2qm74	5081	5	well	well	RB
cord-015021-pol2qm74	5081	6	recognized	recognize	VBN
cord-015021-pol2qm74	5081	7	in	in	IN
cord-015021-pol2qm74	5081	8	sepsis	sepsis	NN
cord-015021-pol2qm74	5081	9	,	,	,
cord-015021-pol2qm74	5081	10	it	-PRON-	PRP
cord-015021-pol2qm74	5081	11	is	be	VBZ
cord-015021-pol2qm74	5081	12	generally	generally	RB
cord-015021-pol2qm74	5081	13	thought	think	VBN
cord-015021-pol2qm74	5081	14	to	to	TO
cord-015021-pol2qm74	5081	15	be	be	VB
cord-015021-pol2qm74	5081	16	a	a	DT
cord-015021-pol2qm74	5081	17	late	late	JJ
cord-015021-pol2qm74	5081	18	complication	complication	NN
cord-015021-pol2qm74	5081	19	following	follow	VBG
cord-015021-pol2qm74	5081	20	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	5081	21	and	and	CC
cord-015021-pol2qm74	5081	22	renal	renal	JJ
cord-015021-pol2qm74	5081	23	failure	failure	NN
cord-015021-pol2qm74	5081	24	.	.	.
cord-015021-pol2qm74	5082	1	Jaundice	jaundice	NN
cord-015021-pol2qm74	5082	2	,	,	,
cord-015021-pol2qm74	5082	3	hypoglycemia	hypoglycemia	NN
cord-015021-pol2qm74	5082	4	,	,	,
cord-015021-pol2qm74	5082	5	encephalopathy	encephalopathy	NN
cord-015021-pol2qm74	5082	6	and	and	CC
cord-015021-pol2qm74	5082	7	bleeding	bleed	VBG
cord-015021-pol2qm74	5082	8	secondary	secondary	JJ
cord-015021-pol2qm74	5082	9	to	to	IN
cord-015021-pol2qm74	5082	10	low	low	JJ
cord-015021-pol2qm74	5082	11	levels	level	NNS
cord-015021-pol2qm74	5082	12	of	of	IN
cord-015021-pol2qm74	5082	13	liver	liver	NN
cord-015021-pol2qm74	5082	14	-	-	HYPH
cord-015021-pol2qm74	5082	15	synthesizing	synthesize	VBG
cord-015021-pol2qm74	5082	16	clotting	clotting	NN
cord-015021-pol2qm74	5082	17	factors	factor	NNS
cord-015021-pol2qm74	5082	18	are	be	VBP
cord-015021-pol2qm74	5082	19	,	,	,
cord-015021-pol2qm74	5082	20	however	however	RB
cord-015021-pol2qm74	5082	21	,	,	,
cord-015021-pol2qm74	5082	22	signs	sign	NNS
cord-015021-pol2qm74	5082	23	of	of	IN
cord-015021-pol2qm74	5082	24	rather	rather	RB
cord-015021-pol2qm74	5082	25	severe	severe	JJ
cord-015021-pol2qm74	5082	26	end	end	NN
cord-015021-pol2qm74	5082	27	-	-	HYPH
cord-015021-pol2qm74	5082	28	stage	stage	NN
cord-015021-pol2qm74	5082	29	hepatic	hepatic	JJ
cord-015021-pol2qm74	5082	30	failure	failure	NN
cord-015021-pol2qm74	5082	31	.	.	.
cord-015021-pol2qm74	5083	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	5083	2	,	,	,
cord-015021-pol2qm74	5083	3	elevated	elevated	JJ
cord-015021-pol2qm74	5083	4	liver	liver	NN
cord-015021-pol2qm74	5083	5	enzymes	enzyme	NNS
cord-015021-pol2qm74	5083	6	(	(	-LRB-
cord-015021-pol2qm74	5083	7	SGOT	SGOT	NNP
cord-015021-pol2qm74	5083	8	and	and	CC
cord-015021-pol2qm74	5083	9	SGPT	SGPT	NNP
cord-015021-pol2qm74	5083	10	)	)	-RRB-
cord-015021-pol2qm74	5083	11	represent	represent	VBP
cord-015021-pol2qm74	5083	12	hepatucyte	hepatucyte	NNP
cord-015021-pol2qm74	5083	13	damage	damage	NN
cord-015021-pol2qm74	5083	14	and	and	CC
cord-015021-pol2qm74	5083	15	not	not	RB
cord-015021-pol2qm74	5083	16	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5083	17	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5083	18	.	.	.
cord-015021-pol2qm74	5084	1	In	in	IN
cord-015021-pol2qm74	5084	2	view	view	NN
cord-015021-pol2qm74	5084	3	of	of	IN
cord-015021-pol2qm74	5084	4	this	this	DT
cord-015021-pol2qm74	5084	5	,	,	,
cord-015021-pol2qm74	5084	6	a	a	DT
cord-015021-pol2qm74	5084	7	more	more	RBR
cord-015021-pol2qm74	5084	8	sensitive	sensitive	JJ
cord-015021-pol2qm74	5084	9	indicator	indicator	NN
cord-015021-pol2qm74	5084	10	of	of	IN
cord-015021-pol2qm74	5084	11	hepatic	hepatic	JJ
cord-015021-pol2qm74	5084	12	function	function	NN
cord-015021-pol2qm74	5084	13	is	be	VBZ
cord-015021-pol2qm74	5084	14	desirable	desirable	JJ
cord-015021-pol2qm74	5084	15	in	in	IN
cord-015021-pol2qm74	5084	16	order	order	NN
cord-015021-pol2qm74	5084	17	to	to	TO
cord-015021-pol2qm74	5084	18	detect	detect	VB
cord-015021-pol2qm74	5084	19	early	early	JJ
cord-015021-pol2qm74	5084	20	hepatic	hepatic	JJ
cord-015021-pol2qm74	5084	21	abnormality	abnormality	NN
cord-015021-pol2qm74	5084	22	.	.	.
cord-015021-pol2qm74	5085	1	In	in	IN
cord-015021-pol2qm74	5085	2	this	this	DT
cord-015021-pol2qm74	5085	3	respect	respect	NN
cord-015021-pol2qm74	5085	4	,	,	,
cord-015021-pol2qm74	5085	5	indocyanine	indocyanine	NN
cord-015021-pol2qm74	5085	6	green	green	JJ
cord-015021-pol2qm74	5085	7	(	(	-LRB-
cord-015021-pol2qm74	5085	8	ICG	ICG	NNP
cord-015021-pol2qm74	5085	9	)	)	-RRB-
cord-015021-pol2qm74	5085	10	is	be	VBZ
cord-015021-pol2qm74	5085	11	a	a	DT
cord-015021-pol2qm74	5085	12	tricarbocyanine	tricarbocyanine	JJ
cord-015021-pol2qm74	5085	13	dye	dye	NN
cord-015021-pol2qm74	5085	14	that	that	WDT
cord-015021-pol2qm74	5085	15	possesses	possess	VBZ
cord-015021-pol2qm74	5085	16	several	several	JJ
cord-015021-pol2qm74	5085	17	properties	property	NNS
cord-015021-pol2qm74	5085	18	which	which	WDT
cord-015021-pol2qm74	5085	19	makes	make	VBZ
cord-015021-pol2qm74	5085	20	it	-PRON-	PRP
cord-015021-pol2qm74	5085	21	particularly	particularly	RB
cord-015021-pol2qm74	5085	22	valuable	valuable	JJ
cord-015021-pol2qm74	5085	23	inthe	inthe	JJ
cord-015021-pol2qm74	5085	24	assessment	assessment	NN
cord-015021-pol2qm74	5085	25	ofhepatic	ofhepatic	JJ
cord-015021-pol2qm74	5085	26	function	function	NN
cord-015021-pol2qm74	5085	27	.	.	.
cord-015021-pol2qm74	5086	1	This	this	DT
cord-015021-pol2qm74	5086	2	dye	dye	NN
cord-015021-pol2qm74	5086	3	is	be	VBZ
cord-015021-pol2qm74	5086	4	bound	bind	VBN
cord-015021-pol2qm74	5086	5	m	m	CD
cord-015021-pol2qm74	5086	6	albumin	albumin	NN
cord-015021-pol2qm74	5086	7	and	and	CC
cord-015021-pol2qm74	5086	8	is	be	VBZ
cord-015021-pol2qm74	5086	9	cleared	clear	VBN
cord-015021-pol2qm74	5086	10	exclusively	exclusively	RB
cord-015021-pol2qm74	5086	11	by	by	IN
cord-015021-pol2qm74	5086	12	the	the	DT
cord-015021-pol2qm74	5086	13	liver	liver	NN
cord-015021-pol2qm74	5086	14	through	through	IN
cord-015021-pol2qm74	5086	15	an	an	DT
cord-015021-pol2qm74	5086	16	energydependent	energydependent	NN
cord-015021-pol2qm74	5086	17	membrane	membrane	NN
cord-015021-pol2qm74	5086	18	transport	transport	NN
cord-015021-pol2qm74	5086	19	process	process	NN
cord-015021-pol2qm74	5086	20	and	and	CC
cord-015021-pol2qm74	5086	21	is	be	VBZ
cord-015021-pol2qm74	5086	22	nontoxic	nontoxic	JJ
cord-015021-pol2qm74	5086	23	at	at	IN
cord-015021-pol2qm74	5086	24	lower	low	JJR
cord-015021-pol2qm74	5086	25	doses	dose	NNS
cord-015021-pol2qm74	5086	26	.	.	.
cord-015021-pol2qm74	5087	1	We	-PRON-	PRP
cord-015021-pol2qm74	5087	2	propose	propose	VBP
cord-015021-pol2qm74	5087	3	that	that	IN
cord-015021-pol2qm74	5087	4	maximal	maximal	JJ
cord-015021-pol2qm74	5087	5	velocity	velocity	NN
cord-015021-pol2qm74	5087	6	(	(	-LRB-
cord-015021-pol2qm74	5087	7	Vm~	Vm~	NNP
cord-015021-pol2qm74	5087	8	,	,	,
cord-015021-pol2qm74	5087	9	)	)	-RRB-
cord-015021-pol2qm74	5087	10	of	of	IN
cord-015021-pol2qm74	5087	11	ICG	ICG	NNP
cord-015021-pol2qm74	5087	12	clearance	clearance	NN
cord-015021-pol2qm74	5087	13	is	be	VBZ
cord-015021-pol2qm74	5087	14	a	a	DT
cord-015021-pol2qm74	5087	15	valuable	valuable	JJ
cord-015021-pol2qm74	5087	16	measure	measure	NN
cord-015021-pol2qm74	5087	17	of	of	IN
cord-015021-pol2qm74	5087	18	active	active	JJ
cord-015021-pol2qm74	5087	19	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5087	20	function	function	NN
cord-015021-pol2qm74	5087	21	,	,	,
cord-015021-pol2qm74	5087	22	since	since	IN
cord-015021-pol2qm74	5087	23	the	the	DT
cord-015021-pol2qm74	5087	24	total	total	JJ
cord-015021-pol2qm74	5087	25	concentration	concentration	NN
cord-015021-pol2qm74	5087	26	of	of	IN
cord-015021-pol2qm74	5087	27	functioning	function	VBG
cord-015021-pol2qm74	5087	28	receptors	receptor	NNS
cord-015021-pol2qm74	5087	29	is	be	VBZ
cord-015021-pol2qm74	5087	30	directly	directly	RB
cord-015021-pol2qm74	5087	31	proportional	proportional	JJ
cord-015021-pol2qm74	5087	32	to	to	IN
cord-015021-pol2qm74	5087	33	Vm~.	vm~.	NN
cord-015021-pol2qm74	5088	1	We	-PRON-	PRP
cord-015021-pol2qm74	5088	2	have	have	VBP
cord-015021-pol2qm74	5088	3	utilized	utilize	VBN
cord-015021-pol2qm74	5088	4	a	a	DT
cord-015021-pol2qm74	5088	5	fiber	fiber	NN
cord-015021-pol2qm74	5088	6	optic	optic	JJ
cord-015021-pol2qm74	5088	7	catheter	catheter	NN
cord-015021-pol2qm74	5088	8	and	and	CC
cord-015021-pol2qm74	5088	9	an	an	DT
cord-015021-pol2qm74	5088	10	in	in	IN
cord-015021-pol2qm74	5088	11	vivo	vivo	FW
cord-015021-pol2qm74	5088	12	hemoreflectometar	hemoreflectometar	NNP
cord-015021-pol2qm74	5088	13	to	to	TO
cord-015021-pol2qm74	5088	14	continuously	continuously	RB
cord-015021-pol2qm74	5088	15	measure	measure	VB
cord-015021-pol2qm74	5088	16	the	the	DT
cord-015021-pol2qm74	5088	17	administered	administer	VBN
cord-015021-pol2qm74	5088	18	ICG	ICG	NNP
cord-015021-pol2qm74	5088	19	in	in	IN
cord-015021-pol2qm74	5088	20	vivo	vivo	NN
cord-015021-pol2qm74	5088	21	and	and	CC
cord-015021-pol2qm74	5088	22	consequently	consequently	RB
cord-015021-pol2qm74	5088	23	determine	determine	VB
cord-015021-pol2qm74	5088	24	its	-PRON-	PRP$
cord-015021-pol2qm74	5088	25	clearance	clearance	NN
cord-015021-pol2qm74	5088	26	without	without	IN
cord-015021-pol2qm74	5088	27	the	the	DT
cord-015021-pol2qm74	5088	28	need	need	NN
cord-015021-pol2qm74	5088	29	of	of	IN
cord-015021-pol2qm74	5088	30	blood	blood	NN
cord-015021-pol2qm74	5088	31	sampling	sampling	NN
cord-015021-pol2qm74	5088	32	.	.	.
cord-015021-pol2qm74	5089	1	Using	use	VBG
cord-015021-pol2qm74	5089	2	this	this	DT
cord-015021-pol2qm74	5089	3	technique	technique	NN
cord-015021-pol2qm74	5089	4	,	,	,
cord-015021-pol2qm74	5089	5	we	-PRON-	PRP
cord-015021-pol2qm74	5089	6	have	have	VBP
cord-015021-pol2qm74	5089	7	found	find	VBN
cord-015021-pol2qm74	5089	8	that	that	IN
cord-015021-pol2qm74	5089	9	in	in	IN
cord-015021-pol2qm74	5089	10	the	the	DT
cord-015021-pol2qm74	5089	11	early	early	JJ
cord-015021-pol2qm74	5089	12	stages	stage	NNS
cord-015021-pol2qm74	5089	13	of	of	IN
cord-015021-pol2qm74	5089	14	sepsis	sepsis	NN
cord-015021-pol2qm74	5089	15	(	(	-LRB-
cord-015021-pol2qm74	5089	16	i.e.	i.e.	FW
cord-015021-pol2qm74	5089	17	,	,	,
cord-015021-pol2qm74	5089	18	2	2	CD
cord-015021-pol2qm74	5089	19	and	and	CC
cord-015021-pol2qm74	5089	20	5	5	CD
cord-015021-pol2qm74	5089	21	h	h	NN
cord-015021-pol2qm74	5089	22	following	follow	VBG
cord-015021-pol2qm74	5089	23	cecal	cecal	JJ
cord-015021-pol2qm74	5089	24	ligation	ligation	NN
cord-015021-pol2qm74	5089	25	and	and	CC
cord-015021-pol2qm74	5089	26	puncture	puncture	NN
cord-015021-pol2qm74	5089	27	)	)	-RRB-
cord-015021-pol2qm74	5089	28	,	,	,
cord-015021-pol2qm74	5089	29	the	the	DT
cord-015021-pol2qm74	5089	30	Vm~	Vm~	NNP
cord-015021-pol2qm74	5089	31	and	and	CC
cord-015021-pol2qm74	5089	32	kinetic	kinetic	JJ
cord-015021-pol2qm74	5089	33	constant	constant	NN
cord-015021-pol2qm74	5089	34	(	(	-LRB-
cord-015021-pol2qm74	5089	35	K=	K=	NNP
cord-015021-pol2qm74	5089	36	)	)	-RRB-
cord-015021-pol2qm74	5089	37	of	of	IN
cord-015021-pol2qm74	5089	38	ICG	ICG	NNP
cord-015021-pol2qm74	5089	39	clearance	clearance	NN
cord-015021-pol2qm74	5089	40	was	be	VBD
cord-015021-pol2qm74	5089	41	significantly	significantly	RB
cord-015021-pol2qm74	5089	42	depressed	depressed	JJ
cord-015021-pol2qm74	5089	43	.	.	.
cord-015021-pol2qm74	5090	1	It	-PRON-	PRP
cord-015021-pol2qm74	5090	2	should	should	MD
cord-015021-pol2qm74	5090	3	be	be	VB
cord-015021-pol2qm74	5090	4	noted	note	VBN
cord-015021-pol2qm74	5090	5	that	that	IN
cord-015021-pol2qm74	5090	6	at	at	IN
cord-015021-pol2qm74	5090	7	this	this	DT
cord-015021-pol2qm74	5090	8	stage	stage	NN
cord-015021-pol2qm74	5090	9	of	of	IN
cord-015021-pol2qm74	5090	10	sepsis	sepsis	NN
cord-015021-pol2qm74	5090	11	,	,	,
cord-015021-pol2qm74	5090	12	there	there	EX
cord-015021-pol2qm74	5090	13	was	be	VBD
cord-015021-pol2qm74	5090	14	no	no	DT
cord-015021-pol2qm74	5090	15	elevation	elevation	NN
cord-015021-pol2qm74	5090	16	in	in	IN
cord-015021-pol2qm74	5090	17	serum	serum	NN
cord-015021-pol2qm74	5090	18	enzyme	enzyme	NN
cord-015021-pol2qm74	5090	19	levels	level	NNS
cord-015021-pol2qm74	5090	20	.	.	.
cord-015021-pol2qm74	5091	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	5091	2	,	,	,
cord-015021-pol2qm74	5091	3	hepatic	hepatic	JJ
cord-015021-pol2qm74	5091	4	blood	blood	NN
cord-015021-pol2qm74	5091	5	flow	flow	NN
cord-015021-pol2qm74	5091	6	and	and	CC
cord-015021-pol2qm74	5091	7	cardiac	cardiac	JJ
cord-015021-pol2qm74	5091	8	output	output	NN
cord-015021-pol2qm74	5091	9	increased	increase	VBD
cord-015021-pol2qm74	5091	10	at	at	IN
cord-015021-pol2qm74	5091	11	the	the	DT
cord-015021-pol2qm74	5091	12	above	above	RB
cord-015021-pol2qm74	5091	13	mentioned	mention	VBN
cord-015021-pol2qm74	5091	14	time	time	NN
cord-015021-pol2qm74	5091	15	points	point	NNS
cord-015021-pol2qm74	5091	16	.	.	.
cord-015021-pol2qm74	5092	1	Thus	thus	RB
cord-015021-pol2qm74	5092	2	,	,	,
cord-015021-pol2qm74	5092	3	the	the	DT
cord-015021-pol2qm74	5092	4	extremely	extremely	RB
cord-015021-pol2qm74	5092	5	early	early	JJ
cord-015021-pol2qm74	5092	6	depression	depression	NN
cord-015021-pol2qm74	5092	7	in	in	IN
cord-015021-pol2qm74	5092	8	active	active	JJ
cord-015021-pol2qm74	5092	9	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5092	10	function	function	NN
cord-015021-pol2qm74	5092	11	in	in	IN
cord-015021-pol2qm74	5092	12	sepsis	sepsis	NN
cord-015021-pol2qm74	5092	13	,	,	,
cord-015021-pol2qm74	5092	14	despite	despite	IN
cord-015021-pol2qm74	5092	15	the	the	DT
cord-015021-pol2qm74	5092	16	increased	increase	VBN
cord-015021-pol2qm74	5092	17	hepatic	hepatic	JJ
cord-015021-pol2qm74	5092	18	blood	blood	NN
cord-015021-pol2qm74	5092	19	flow	flow	NN
cord-015021-pol2qm74	5092	20	and	and	CC
cord-015021-pol2qm74	5092	21	cardiac	cardiac	JJ
cord-015021-pol2qm74	5092	22	output	output	NN
cord-015021-pol2qm74	5092	23	,	,	,
cord-015021-pol2qm74	5092	24	may	may	MD
cord-015021-pol2qm74	5092	25	form	form	VB
cord-015021-pol2qm74	5092	26	the	the	DT
cord-015021-pol2qm74	5092	27	basis	basis	NN
cord-015021-pol2qm74	5092	28	for	for	IN
cord-015021-pol2qm74	5092	29	cellular	cellular	JJ
cord-015021-pol2qm74	5092	30	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	5092	31	leading	lead	VBG
cord-015021-pol2qm74	5092	32	to	to	IN
cord-015021-pol2qm74	5092	33	multiple	multiple	JJ
cord-015021-pol2qm74	5092	34	organ	organ	NN
cord-015021-pol2qm74	5092	35	failure	failure	NN
cord-015021-pol2qm74	5092	36	during	during	IN
cord-015021-pol2qm74	5092	37	sepsis	sepsis	NN
cord-015021-pol2qm74	5092	38	.	.	.
cord-015021-pol2qm74	5093	1	Additional	additional	JJ
cord-015021-pol2qm74	5093	2	studies	study	NNS
cord-015021-pol2qm74	5093	3	indicated	indicate	VBD
cord-015021-pol2qm74	5093	4	that	that	IN
cord-015021-pol2qm74	5093	5	following	follow	VBG
cord-015021-pol2qm74	5093	6	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5093	7	,	,	,
cord-015021-pol2qm74	5093	8	active	active	JJ
cord-015021-pol2qm74	5093	9	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5093	10	function	function	NN
cord-015021-pol2qm74	5093	11	was	be	VBD
cord-015021-pol2qm74	5093	12	markedly	markedly	RB
cord-015021-pol2qm74	5093	13	depressed	depressed	JJ
cord-015021-pol2qm74	5093	14	.	.	.
cord-015021-pol2qm74	5094	1	This	this	DT
cord-015021-pol2qm74	5094	2	returned	return	VBD
cord-015021-pol2qm74	5094	3	to	to	IN
cord-015021-pol2qm74	5094	4	prehemorrhage	prehemorrhage	NN
cord-015021-pol2qm74	5094	5	levels	level	NNS
cord-015021-pol2qm74	5094	6	after	after	IN
cord-015021-pol2qm74	5094	7	Ringers	ringer	NNS
cord-015021-pol2qm74	5094	8	lactate	lactate	VBP
cord-015021-pol2qm74	5094	9	resuscitation	resuscitation	NN
cord-015021-pol2qm74	5094	10	,	,	,
cord-015021-pol2qm74	5094	11	however	however	RB
cord-015021-pol2qm74	5094	12	,	,	,
cord-015021-pol2qm74	5094	13	this	this	DT
cord-015021-pol2qm74	5094	14	function	function	NN
cord-015021-pol2qm74	5094	15	was	be	VBD
cord-015021-pol2qm74	5094	16	not	not	RB
cord-015021-pol2qm74	5094	17	maintained	maintain	VBN
cord-015021-pol2qm74	5094	18	and	and	CC
cord-015021-pol2qm74	5094	19	decreased	decrease	VBD
cord-015021-pol2qm74	5094	20	significantly	significantly	RB
cord-015021-pol2qm74	5094	21	after	after	IN
cord-015021-pol2qm74	5094	22	fluid	fluid	JJ
cord-015021-pol2qm74	5094	23	resuscitation	resuscitation	NN
cord-015021-pol2qm74	5094	24	.	.	.
cord-015021-pol2qm74	5095	1	Nevertheless	nevertheless	RB
cord-015021-pol2qm74	5095	2	,	,	,
cord-015021-pol2qm74	5095	3	the	the	DT
cord-015021-pol2qm74	5095	4	depressed	depressed	JJ
cord-015021-pol2qm74	5095	5	active	active	JJ
cord-015021-pol2qm74	5095	6	hepatocelinlar	hepatocelinlar	NNP
cord-015021-pol2qm74	5095	7	function	function	NN
cord-015021-pol2qm74	5095	8	following	follow	VBG
cord-015021-pol2qm74	5095	9	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5095	10	was	be	VBD
cord-015021-pol2qm74	5095	11	markedly	markedly	RB
cord-015021-pol2qm74	5095	12	improved	improve	VBN
cord-015021-pol2qm74	5095	13	by	by	IN
cord-015021-pol2qm74	5095	14	post	post	JJ
cord-015021-pol2qm74	5095	15	-	-	JJ
cord-015021-pol2qm74	5095	16	treatment	treatment	NN
cord-015021-pol2qm74	5095	17	of	of	IN
cord-015021-pol2qm74	5095	18	animals	animal	NNS
cord-015021-pol2qm74	5095	19	with	with	IN
cord-015021-pol2qm74	5095	20	either	either	CC
cord-015021-pol2qm74	5095	21	ATP	ATP	NNP
cord-015021-pol2qm74	5095	22	-	-	HYPH
cord-015021-pol2qm74	5095	23	MgCI2	MgCI2	NNP
cord-015021-pol2qm74	5095	24	,	,	,
cord-015021-pol2qm74	5095	25	peutoxifylline	peutoxifylline	NN
cord-015021-pol2qm74	5095	26	or	or	CC
cord-015021-pol2qm74	5095	27	diltiazem	diltiazem	NN
cord-015021-pol2qm74	5095	28	.	.	.
cord-015021-pol2qm74	5096	1	Thus	thus	RB
cord-015021-pol2qm74	5096	2	,	,	,
cord-015021-pol2qm74	5096	3	the	the	DT
cord-015021-pol2qm74	5096	4	use	use	NN
cord-015021-pol2qm74	5096	5	of	of	IN
cord-015021-pol2qm74	5096	6	ICG	ICG	NNP
cord-015021-pol2qm74	5096	7	clearance	clearance	NN
cord-015021-pol2qm74	5096	8	provides	provide	VBZ
cord-015021-pol2qm74	5096	9	an	an	DT
cord-015021-pol2qm74	5096	10	early	early	JJ
cord-015021-pol2qm74	5096	11	sensitive	sensitive	JJ
cord-015021-pol2qm74	5096	12	indicator	indicator	NN
cord-015021-pol2qm74	5096	13	of	of	IN
cord-015021-pol2qm74	5096	14	hepatic	hepatic	JJ
cord-015021-pol2qm74	5096	15	abnormality	abnormality	NN
cord-015021-pol2qm74	5096	16	during	during	IN
cord-015021-pol2qm74	5096	17	sepsis	sepsis	NN
cord-015021-pol2qm74	5096	18	and	and	CC
cord-015021-pol2qm74	5096	19	following	follow	VBG
cord-015021-pol2qm74	5096	20	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5096	21	and	and	CC
cord-015021-pol2qm74	5096	22	this	this	DT
cord-015021-pol2qm74	5096	23	method	method	NN
cord-015021-pol2qm74	5096	24	should	should	MD
cord-015021-pol2qm74	5096	25	be	be	VB
cord-015021-pol2qm74	5096	26	used	use	VBN
cord-015021-pol2qm74	5096	27	,	,	,
cord-015021-pol2qm74	5096	28	not	not	RB
cord-015021-pol2qm74	5096	29	only	only	RB
cord-015021-pol2qm74	5096	30	experimentally	experimentally	RB
cord-015021-pol2qm74	5096	31	,	,	,
cord-015021-pol2qm74	5096	32	but	but	CC
cord-015021-pol2qm74	5096	33	also	also	RB
cord-015021-pol2qm74	5096	34	in	in	IN
cord-015021-pol2qm74	5096	35	the	the	DT
cord-015021-pol2qm74	5096	36	clinical	clinical	JJ
cord-015021-pol2qm74	5096	37	arena	arena	NN
cord-015021-pol2qm74	5096	38	for	for	IN
cord-015021-pol2qm74	5096	39	the	the	DT
cord-015021-pol2qm74	5096	40	early	early	JJ
cord-015021-pol2qm74	5096	41	detection	detection	NN
cord-015021-pol2qm74	5096	42	of	of	IN
cord-015021-pol2qm74	5096	43	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5096	44	abnormality	abnormality	NN
cord-015021-pol2qm74	5096	45	.	.	.
cord-015021-pol2qm74	5097	1	Although	although	IN
cord-015021-pol2qm74	5097	2	multiple	multiple	JJ
cord-015021-pol2qm74	5097	3	organ	organ	NN
cord-015021-pol2qm74	5097	4	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5097	5	syndrome	syndrome	NN
cord-015021-pol2qm74	5097	6	(	(	-LRB-
cord-015021-pol2qm74	5097	7	MODS	MODS	NNP
cord-015021-pol2qm74	5097	8	)	)	-RRB-
cord-015021-pol2qm74	5097	9	remains	remain	VBZ
cord-015021-pol2qm74	5097	10	a	a	DT
cord-015021-pol2qm74	5097	11	major	major	JJ
cord-015021-pol2qm74	5097	12	cause	cause	NN
cord-015021-pol2qm74	5097	13	of	of	IN
cord-015021-pol2qm74	5097	14	mortality	mortality	NN
cord-015021-pol2qm74	5097	15	and	and	CC
cord-015021-pol2qm74	5097	16	morbidity	morbidity	NN
cord-015021-pol2qm74	5097	17	in	in	IN
cord-015021-pol2qm74	5097	18	intensive	intensive	JJ
cord-015021-pol2qm74	5097	19	care	care	NN
cord-015021-pol2qm74	5097	20	units	unit	NNS
cord-015021-pol2qm74	5097	21	,	,	,
cord-015021-pol2qm74	5097	22	very	very	RB
cord-015021-pol2qm74	5097	23	little	little	JJ
cord-015021-pol2qm74	5097	24	is	be	VBZ
cord-015021-pol2qm74	5097	25	known	know	VBN
cord-015021-pol2qm74	5097	26	about	about	IN
cord-015021-pol2qm74	5097	27	the	the	DT
cord-015021-pol2qm74	5097	28	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5097	29	that	that	WDT
cord-015021-pol2qm74	5097	30	precipitate	precipitate	VBP
cord-015021-pol2qm74	5097	31	its	-PRON-	PRP$
cord-015021-pol2qm74	5097	32	development	development	NN
cord-015021-pol2qm74	5097	33	.	.	.
cord-015021-pol2qm74	5098	1	Since	since	IN
cord-015021-pol2qm74	5098	2	an	an	DT
cord-015021-pol2qm74	5098	3	episode	episode	NN
cord-015021-pol2qm74	5098	4	of	of	IN
cord-015021-pol2qm74	5098	5	inadequate	inadequate	JJ
cord-015021-pol2qm74	5098	6	tissue	tissue	NN
cord-015021-pol2qm74	5098	7	oxygenation	oxygenation	NN
cord-015021-pol2qm74	5098	8	is	be	VBZ
cord-015021-pol2qm74	5098	9	considered	consider	VBN
cord-015021-pol2qm74	5098	10	to	to	TO
cord-015021-pol2qm74	5098	11	be	be	VB
cord-015021-pol2qm74	5098	12	the	the	DT
cord-015021-pol2qm74	5098	13	trigger	trigger	NN
cord-015021-pol2qm74	5098	14	for	for	IN
cord-015021-pol2qm74	5098	15	MODS	mods	NN
cord-015021-pol2qm74	5098	16	,	,	,
cord-015021-pol2qm74	5098	17	we	-PRON-	PRP
cord-015021-pol2qm74	5098	18	have	have	VBP
cord-015021-pol2qm74	5098	19	proposed	propose	VBN
cord-015021-pol2qm74	5098	20	that	that	IN
cord-015021-pol2qm74	5098	21	a	a	DT
cord-015021-pol2qm74	5098	22	primary	primary	JJ
cord-015021-pol2qm74	5098	23	localized	localize	VBN
cord-015021-pol2qm74	5098	24	injury	injury	NN
cord-015021-pol2qm74	5098	25	such	such	JJ
cord-015021-pol2qm74	5098	26	as	as	IN
cord-015021-pol2qm74	5098	27	ischemia	ischemia	NN
cord-015021-pol2qm74	5098	28	/	/	SYM
cord-015021-pol2qm74	5098	29	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5098	30	may	may	MD
cord-015021-pol2qm74	5098	31	be	be	VB
cord-015021-pol2qm74	5098	32	sufficient	sufficient	JJ
cord-015021-pol2qm74	5098	33	to	to	TO
cord-015021-pol2qm74	5098	34	cause	cause	VB
cord-015021-pol2qm74	5098	35	a	a	DT
cord-015021-pol2qm74	5098	36	change	change	NN
cord-015021-pol2qm74	5098	37	of	of	IN
cord-015021-pol2qm74	5098	38	gene	gene	NN
cord-015021-pol2qm74	5098	39	expression	expression	NN
cord-015021-pol2qm74	5098	40	of	of	IN
cord-015021-pol2qm74	5098	41	remote	remote	JJ
cord-015021-pol2qm74	5098	42	and	and	CC
cord-015021-pol2qm74	5098	43	apparently	apparently	RB
cord-015021-pol2qm74	5098	44	unaffected	unaffected	JJ
cord-015021-pol2qm74	5098	45	organs	organ	NNS
cord-015021-pol2qm74	5098	46	.	.	.
cord-015021-pol2qm74	5099	1	Such	such	JJ
cord-015021-pol2qm74	5099	2	modulation	modulation	NN
cord-015021-pol2qm74	5099	3	of	of	IN
cord-015021-pol2qm74	5099	4	remote	remote	JJ
cord-015021-pol2qm74	5099	5	organ	organ	NN
cord-015021-pol2qm74	5099	6	gene	gene	NN
cord-015021-pol2qm74	5099	7	expression	expression	NN
cord-015021-pol2qm74	5099	8	may	may	MD
cord-015021-pol2qm74	5099	9	decrease	decrease	VB
cord-015021-pol2qm74	5099	10	the	the	DT
cord-015021-pol2qm74	5099	11	organ	organ	NN
cord-015021-pol2qm74	5099	12	's	's	POS
cord-015021-pol2qm74	5099	13	tolerance	tolerance	NN
cord-015021-pol2qm74	5099	14	to	to	IN
cord-015021-pol2qm74	5099	15	a	a	DT
cord-015021-pol2qm74	5099	16	subsequent	subsequent	JJ
cord-015021-pol2qm74	5099	17	stress	stress	NN
cord-015021-pol2qm74	5099	18	contributing	contribute	VBG
cord-015021-pol2qm74	5099	19	to	to	IN
cord-015021-pol2qm74	5099	20	the	the	DT
cord-015021-pol2qm74	5099	21	development	development	NN
cord-015021-pol2qm74	5099	22	of	of	IN
cord-015021-pol2qm74	5099	23	MOFS	MOFS	NNP
cord-015021-pol2qm74	5099	24	.	.	.
cord-015021-pol2qm74	5100	1	To	to	TO
cord-015021-pol2qm74	5100	2	test	test	VB
cord-015021-pol2qm74	5100	3	this	this	DT
cord-015021-pol2qm74	5100	4	hypothesis	hypothesis	NN
cord-015021-pol2qm74	5100	5	,	,	,
cord-015021-pol2qm74	5100	6	rats	rat	NNS
cord-015021-pol2qm74	5100	7	were	be	VBD
cord-015021-pol2qm74	5100	8	subjected	subject	VBN
cord-015021-pol2qm74	5100	9	to	to	IN
cord-015021-pol2qm74	5100	10	hepatic	hepatic	JJ
cord-015021-pol2qm74	5100	11	regional	regional	JJ
cord-015021-pol2qm74	5100	12	ischemia	ischemia	NN
cord-015021-pol2qm74	5100	13	by	by	IN
cord-015021-pol2qm74	5100	14	clamping	clamp	VBG
cord-015021-pol2qm74	5100	15	the	the	DT
cord-015021-pol2qm74	5100	16	blood	blood	NN
cord-015021-pol2qm74	5100	17	flow	flow	NN
cord-015021-pol2qm74	5100	18	(	(	-LRB-
cord-015021-pol2qm74	5100	19	hepatic	hepatic	JJ
cord-015021-pol2qm74	5100	20	artery	artery	NN
cord-015021-pol2qm74	5100	21	and	and	CC
cord-015021-pol2qm74	5100	22	portal	portal	JJ
cord-015021-pol2qm74	5100	23	venous	venous	JJ
cord-015021-pol2qm74	5100	24	inflow	inflow	NN
cord-015021-pol2qm74	5100	25	)	)	-RRB-
cord-015021-pol2qm74	5100	26	of	of	IN
cord-015021-pol2qm74	5100	27	the	the	DT
cord-015021-pol2qm74	5100	28	left	left	JJ
cord-015021-pol2qm74	5100	29	and	and	CC
cord-015021-pol2qm74	5100	30	median	median	JJ
cord-015021-pol2qm74	5100	31	liver	liver	NN
cord-015021-pol2qm74	5100	32	lobes	lobe	NNS
cord-015021-pol2qm74	5100	33	.	.	.
cord-015021-pol2qm74	5101	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	5101	2	congestion	congestion	NN
cord-015021-pol2qm74	5101	3	was	be	VBD
cord-015021-pol2qm74	5101	4	prevented	prevent	VBN
cord-015021-pol2qm74	5101	5	by	by	IN
cord-015021-pol2qm74	5101	6	allowing	allow	VBG
cord-015021-pol2qm74	5101	7	flow	flow	NN
cord-015021-pol2qm74	5101	8	through	through	IN
cord-015021-pol2qm74	5101	9	the	the	DT
cord-015021-pol2qm74	5101	10	smaller	small	JJR
cord-015021-pol2qm74	5101	11	right	right	JJ
cord-015021-pol2qm74	5101	12	and	and	CC
cord-015021-pol2qm74	5101	13	caudate	caudate	NN
cord-015021-pol2qm74	5101	14	lobes	lobe	NNS
cord-015021-pol2qm74	5101	15	.	.	.
cord-015021-pol2qm74	5102	1	After	after	IN
cord-015021-pol2qm74	5102	2	60	60	CD
cord-015021-pol2qm74	5102	3	minutes	minute	NNS
cord-015021-pol2qm74	5102	4	of	of	IN
cord-015021-pol2qm74	5102	5	ischemia	ischemia	NN
cord-015021-pol2qm74	5102	6	,	,	,
cord-015021-pol2qm74	5102	7	the	the	DT
cord-015021-pol2qm74	5102	8	clamp	clamp	NN
cord-015021-pol2qm74	5102	9	was	be	VBD
cord-015021-pol2qm74	5102	10	removed	remove	VBN
cord-015021-pol2qm74	5102	11	and	and	CC
cord-015021-pol2qm74	5102	12	the	the	DT
cord-015021-pol2qm74	5102	13	blood	blood	NN
cord-015021-pol2qm74	5102	14	flow	flow	NN
cord-015021-pol2qm74	5102	15	restored	restore	VBN
cord-015021-pol2qm74	5102	16	.	.	.
cord-015021-pol2qm74	5103	1	The	the	DT
cord-015021-pol2qm74	5103	2	animals	animal	NNS
cord-015021-pol2qm74	5103	3	were	be	VBD
cord-015021-pol2qm74	5103	4	allowed	allow	VBN
cord-015021-pol2qm74	5103	5	to	to	TO
cord-015021-pol2qm74	5103	6	recover	recover	VB
cord-015021-pol2qm74	5103	7	for	for	IN
cord-015021-pol2qm74	5103	8	1	1	CD
cord-015021-pol2qm74	5103	9	,	,	,
cord-015021-pol2qm74	5103	10	4	4	CD
cord-015021-pol2qm74	5103	11	and	and	CC
cord-015021-pol2qm74	5103	12	24	24	CD
cord-015021-pol2qm74	5103	13	hours	hour	NNS
cord-015021-pol2qm74	5103	14	.	.	.
cord-015021-pol2qm74	5104	1	Kidneys	kidney	NNS
cord-015021-pol2qm74	5104	2	were	be	VBD
cord-015021-pol2qm74	5104	3	removed	remove	VBN
cord-015021-pol2qm74	5104	4	,	,	,
cord-015021-pol2qm74	5104	5	total	total	JJ
cord-015021-pol2qm74	5104	6	RNA	RNA	NNP
cord-015021-pol2qm74	5104	7	was	be	VBD
cord-015021-pol2qm74	5104	8	isolated	isolate	VBN
cord-015021-pol2qm74	5104	9	and	and	CC
cord-015021-pol2qm74	5104	10	poly(A	poly(a	JJ
cord-015021-pol2qm74	5104	11	)	)	-RRB-
cord-015021-pol2qm74	5104	12	÷	÷	NN
cord-015021-pol2qm74	5104	13	selected	select	VBN
cord-015021-pol2qm74	5104	14	by	by	IN
cord-015021-pol2qm74	5104	15	affinity	affinity	NN
cord-015021-pol2qm74	5104	16	chromatography	chromatography	NN
cord-015021-pol2qm74	5104	17	on	on	IN
cord-015021-pol2qm74	5104	18	oligo(dT	oligo(dt	CD
cord-015021-pol2qm74	5104	19	)	)	-RRB-
cord-015021-pol2qm74	5104	20	columns	column	NNS
cord-015021-pol2qm74	5104	21	.	.	.
cord-015021-pol2qm74	5105	1	Message	message	NN
cord-015021-pol2qm74	5105	2	was	be	VBD
cord-015021-pol2qm74	5105	3	in	in	IN
cord-015021-pol2qm74	5105	4	vitro	vitro	FW
cord-015021-pol2qm74	5105	5	translated	translate	VBN
cord-015021-pol2qm74	5105	6	using	use	VBG
cord-015021-pol2qm74	5105	7	rabbit	rabbit	NN
cord-015021-pol2qm74	5105	8	reticulocyte	reticulocyte	NNP
cord-015021-pol2qm74	5105	9	Iysates	Iysates	NNPS
cord-015021-pol2qm74	5105	10	in	in	IN
cord-015021-pol2qm74	5105	11	the	the	DT
cord-015021-pol2qm74	5105	12	presence	presence	NN
cord-015021-pol2qm74	5105	13	of	of	IN
cord-015021-pol2qm74	5105	14	radioactive	radioactive	JJ
cord-015021-pol2qm74	5105	15	amino	amino	NN
cord-015021-pol2qm74	5105	16	acids	acid	NNS
cord-015021-pol2qm74	5105	17	.	.	.
cord-015021-pol2qm74	5106	1	The	the	DT
cord-015021-pol2qm74	5106	2	gene	gene	NN
cord-015021-pol2qm74	5106	3	products	product	NNS
cord-015021-pol2qm74	5106	4	(	(	-LRB-
cord-015021-pol2qm74	5106	5	radiolabeled	radiolabele	VBN
cord-015021-pol2qm74	5106	6	polypeptides	polypeptide	NNS
cord-015021-pol2qm74	5106	7	)	)	-RRB-
cord-015021-pol2qm74	5106	8	were	be	VBD
cord-015021-pol2qm74	5106	9	fractionated	fractionate	VBN
cord-015021-pol2qm74	5106	10	by	by	IN
cord-015021-pol2qm74	5106	11	two	two	CD
cord-015021-pol2qm74	5106	12	dimensional	dimensional	JJ
cord-015021-pol2qm74	5106	13	gel	gel	NN
cord-015021-pol2qm74	5106	14	electrophoresis	electrophoresis	NN
cord-015021-pol2qm74	5106	15	,	,	,
cord-015021-pol2qm74	5106	16	and	and	CC
cord-015021-pol2qm74	5106	17	visualized	visualize	VBN
cord-015021-pol2qm74	5106	18	by	by	IN
cord-015021-pol2qm74	5106	19	fluorography	fluorography	NNP
cord-015021-pol2qm74	5106	20	.	.	.
cord-015021-pol2qm74	5107	1	Analyses	analysis	NNS
cord-015021-pol2qm74	5107	2	of	of	IN
cord-015021-pol2qm74	5107	3	the	the	DT
cord-015021-pol2qm74	5107	4	two	two	CD
cord-015021-pol2qm74	5107	5	dimensional	dimensional	JJ
cord-015021-pol2qm74	5107	6	fluorograms	fluorogram	NNS
cord-015021-pol2qm74	5107	7	indicate	indicate	VBP
cord-015021-pol2qm74	5107	8	that	that	IN
cord-015021-pol2qm74	5107	9	there	there	EX
cord-015021-pol2qm74	5107	10	is	be	VBZ
cord-015021-pol2qm74	5107	11	a	a	DT
cord-015021-pol2qm74	5107	12	dramatic	dramatic	JJ
cord-015021-pol2qm74	5107	13	change	change	NN
cord-015021-pol2qm74	5107	14	in	in	IN
cord-015021-pol2qm74	5107	15	the	the	DT
cord-015021-pol2qm74	5107	16	electrophoretic	electrophoretic	JJ
cord-015021-pol2qm74	5107	17	pattern	pattern	NN
cord-015021-pol2qm74	5107	18	of	of	IN
cord-015021-pol2qm74	5107	19	in	in	FW
cord-015021-pol2qm74	5107	20	vitro	vitro	FW
cord-015021-pol2qm74	5107	21	translated	translate	VBN
cord-015021-pol2qm74	5107	22	products	product	NNS
cord-015021-pol2qm74	5107	23	in	in	IN
cord-015021-pol2qm74	5107	24	samples	sample	NNS
cord-015021-pol2qm74	5107	25	corresponding	correspond	VBG
cord-015021-pol2qm74	5107	26	to	to	IN
cord-015021-pol2qm74	5107	27	kidneys	kidney	NNS
cord-015021-pol2qm74	5107	28	obtained	obtain	VBN
cord-015021-pol2qm74	5107	29	after	after	IN
cord-015021-pol2qm74	5107	30	60	60	CD
cord-015021-pol2qm74	5107	31	minutes	minute	NNS
cord-015021-pol2qm74	5107	32	of	of	IN
cord-015021-pol2qm74	5107	33	hepatic	hepatic	JJ
cord-015021-pol2qm74	5107	34	ischemia	ischemia	NN
cord-015021-pol2qm74	5107	35	and	and	CC
cord-015021-pol2qm74	5107	36	24	24	CD
cord-015021-pol2qm74	5107	37	hours	hour	NNS
cord-015021-pol2qm74	5107	38	of	of	IN
cord-015021-pol2qm74	5107	39	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5107	40	with	with	IN
cord-015021-pol2qm74	5107	41	respect	respect	NN
cord-015021-pol2qm74	5107	42	to	to	IN
cord-015021-pol2qm74	5107	43	kidney	kidney	NN
cord-015021-pol2qm74	5107	44	samples	sample	NNS
cord-015021-pol2qm74	5107	45	obtained	obtain	VBN
cord-015021-pol2qm74	5107	46	after	after	IN
cord-015021-pol2qm74	5107	47	sham	sham	NN
cord-015021-pol2qm74	5107	48	operation	operation	NN
cord-015021-pol2qm74	5107	49	or	or	CC
cord-015021-pol2qm74	5107	50	from	from	IN
cord-015021-pol2qm74	5107	51	control	control	NN
cord-015021-pol2qm74	5107	52	rats	rat	NNS
cord-015021-pol2qm74	5107	53	.	.	.
cord-015021-pol2qm74	5108	1	The	the	DT
cord-015021-pol2qm74	5108	2	latter	latter	JJ
cord-015021-pol2qm74	5108	3	were	be	VBD
cord-015021-pol2qm74	5108	4	not	not	RB
cord-015021-pol2qm74	5108	5	subjected	subject	VBN
cord-015021-pol2qm74	5108	6	to	to	IN
cord-015021-pol2qm74	5108	7	any	any	DT
cord-015021-pol2qm74	5108	8	surgical	surgical	JJ
cord-015021-pol2qm74	5108	9	manipulation	manipulation	NN
cord-015021-pol2qm74	5108	10	.	.	.
cord-015021-pol2qm74	5109	1	These	these	DT
cord-015021-pol2qm74	5109	2	studies	study	NNS
cord-015021-pol2qm74	5109	3	suggest	suggest	VBP
cord-015021-pol2qm74	5109	4	that	that	IN
cord-015021-pol2qm74	5109	5	the	the	DT
cord-015021-pol2qm74	5109	6	gene	gene	NN
cord-015021-pol2qm74	5109	7	expression	expression	NN
cord-015021-pol2qm74	5109	8	of	of	IN
cord-015021-pol2qm74	5109	9	the	the	DT
cord-015021-pol2qm74	5109	10	kidneys	kidney	NNS
cord-015021-pol2qm74	5109	11	is	be	VBZ
cord-015021-pol2qm74	5109	12	specifically	specifically	RB
cord-015021-pol2qm74	5109	13	modified	modify	VBN
cord-015021-pol2qm74	5109	14	after	after	IN
cord-015021-pol2qm74	5109	15	a	a	DT
cord-015021-pol2qm74	5109	16	remote	remote	JJ
cord-015021-pol2qm74	5109	17	organ	organ	NN
cord-015021-pol2qm74	5109	18	injury	injury	NN
cord-015021-pol2qm74	5109	19	(	(	-LRB-
cord-015021-pol2qm74	5109	20	hepatic	hepatic	JJ
cord-015021-pol2qm74	5109	21	ischemia	ischemia	NN
cord-015021-pol2qm74	5109	22	/	/	SYM
cord-015021-pol2qm74	5109	23	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5109	24	)	)	-RRB-
cord-015021-pol2qm74	5109	25	.	.	.
cord-015021-pol2qm74	5110	1	We	-PRON-	PRP
cord-015021-pol2qm74	5110	2	speculate	speculate	VBP
cord-015021-pol2qm74	5110	3	that	that	IN
cord-015021-pol2qm74	5110	4	this	this	DT
cord-015021-pol2qm74	5110	5	change	change	NN
cord-015021-pol2qm74	5110	6	of	of	IN
cord-015021-pol2qm74	5110	7	gene	gene	NN
cord-015021-pol2qm74	5110	8	expression	expression	NN
cord-015021-pol2qm74	5110	9	in	in	IN
cord-015021-pol2qm74	5110	10	kidneys	kidney	NNS
cord-015021-pol2qm74	5110	11	after	after	IN
cord-015021-pol2qm74	5110	12	an	an	DT
cord-015021-pol2qm74	5110	13	indirect	indirect	JJ
cord-015021-pol2qm74	5110	14	injury	injury	NN
cord-015021-pol2qm74	5110	15	may	may	MD
cord-015021-pol2qm74	5110	16	be	be	VB
cord-015021-pol2qm74	5110	17	part	part	NN
cord-015021-pol2qm74	5110	18	of	of	IN
cord-015021-pol2qm74	5110	19	the	the	DT
cord-015021-pol2qm74	5110	20	early	early	JJ
cord-015021-pol2qm74	5110	21	events	event	NNS
cord-015021-pol2qm74	5110	22	leading	lead	VBG
cord-015021-pol2qm74	5110	23	to	to	IN
cord-015021-pol2qm74	5110	24	the	the	DT
cord-015021-pol2qm74	5110	25	development	development	NN
cord-015021-pol2qm74	5110	26	of	of	IN
cord-015021-pol2qm74	5110	27	MODS	mod	NNS
cord-015021-pol2qm74	5110	28	.	.	.
cord-015021-pol2qm74	5111	1	A	a	DT
cord-015021-pol2qm74	5111	2	priming	prime	VBG
cord-015021-pol2qm74	5111	3	event	event	NN
cord-015021-pol2qm74	5111	4	,	,	,
cord-015021-pol2qm74	5111	5	e.g.	e.g.	IN
cord-015021-pol2qm74	5111	6	local	local	JJ
cord-015021-pol2qm74	5111	7	ischemia	ischemia	NN
cord-015021-pol2qm74	5111	8	,	,	,
cord-015021-pol2qm74	5111	9	in	in	IN
cord-015021-pol2qm74	5111	10	combination	combination	NN
cord-015021-pol2qm74	5111	11	with	with	IN
cord-015021-pol2qm74	5111	12	a	a	DT
cord-015021-pol2qm74	5111	13	second	second	JJ
cord-015021-pol2qm74	5111	14	insult	insult	NN
cord-015021-pol2qm74	5111	15	,	,	,
cord-015021-pol2qm74	5111	16	e.g.	e.g.	RB
cord-015021-pol2qm74	5111	17	sepsis	sepsis	NN
cord-015021-pol2qm74	5111	18	,	,	,
cord-015021-pol2qm74	5111	19	may	may	MD
cord-015021-pol2qm74	5111	20	amplify	amplify	VB
cord-015021-pol2qm74	5111	21	a	a	DT
cord-015021-pol2qm74	5111	22	host	host	NN
cord-015021-pol2qm74	5111	23	's	's	POS
cord-015021-pol2qm74	5111	24	response	response	NN
cord-015021-pol2qm74	5111	25	and	and	CC
cord-015021-pol2qm74	5111	26	lead	lead	VB
cord-015021-pol2qm74	5111	27	to	to	IN
cord-015021-pol2qm74	5111	28	multiple	multiple	JJ
cord-015021-pol2qm74	5111	29	organ	organ	NN
cord-015021-pol2qm74	5111	30	failure	failure	NN
cord-015021-pol2qm74	5111	31	.	.	.
cord-015021-pol2qm74	5112	1	To	to	TO
cord-015021-pol2qm74	5112	2	better	well	RBR
cord-015021-pol2qm74	5112	3	understand	understand	VB
cord-015021-pol2qm74	5112	4	the	the	DT
cord-015021-pol2qm74	5112	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5112	6	involved	involve	VBN
cord-015021-pol2qm74	5112	7	in	in	IN
cord-015021-pol2qm74	5112	8	the	the	DT
cord-015021-pol2qm74	5112	9	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	5112	10	,	,	,
cord-015021-pol2qm74	5112	11	male	male	JJ
cord-015021-pol2qm74	5112	12	Fischer	Fischer	NNP
cord-015021-pol2qm74	5112	13	rats	rat	NNS
cord-015021-pol2qm74	5112	14	were	be	VBD
cord-015021-pol2qm74	5112	15	subjected	subject	VBN
cord-015021-pol2qm74	5112	16	to	to	IN
cord-015021-pol2qm74	5112	17	20	20	CD
cord-015021-pol2qm74	5112	18	min	min	NN
cord-015021-pol2qm74	5112	19	of	of	IN
cord-015021-pol2qm74	5112	20	hepatic	hepatic	JJ
cord-015021-pol2qm74	5112	21	ischemia	ischemia	NN
cord-015021-pol2qm74	5112	22	followed	follow	VBN
cord-015021-pol2qm74	5112	23	by	by	IN
cord-015021-pol2qm74	5112	24	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5112	25	(	(	-LRB-
cord-015021-pol2qm74	5112	26	RP	RP	NNP
cord-015021-pol2qm74	5112	27	)	)	-RRB-
cord-015021-pol2qm74	5112	28	and	and	CC
cord-015021-pol2qm74	5112	29	injection	injection	NN
cord-015021-pol2qm74	5112	30	of	of	IN
cord-015021-pol2qm74	5112	31	0.5	0.5	CD
cord-015021-pol2qm74	5112	32	mg	mg	NNP
cord-015021-pol2qm74	5112	33	/	/	SYM
cord-015021-pol2qm74	5112	34	kg	kg	NNP
cord-015021-pol2qm74	5112	35	Salmonella	Salmonella	NNP
cord-015021-pol2qm74	5112	36	enteritidis	enteritidis	NN
cord-015021-pol2qm74	5112	37	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5112	38	(	(	-LRB-
cord-015021-pol2qm74	5112	39	ET	ET	NNP
cord-015021-pol2qm74	5112	40	)	)	-RRB-
cord-015021-pol2qm74	5112	41	at	at	IN
cord-015021-pol2qm74	5112	42	30	30	CD
cord-015021-pol2qm74	5112	43	min	min	NN
cord-015021-pol2qm74	5112	44	of	of	IN
cord-015021-pol2qm74	5112	45	RP	RP	NNP
cord-015021-pol2qm74	5112	46	.	.	.
cord-015021-pol2qm74	5113	1	ET	ET	NNP
cord-015021-pol2qm74	5113	2	injection	injection	NN
cord-015021-pol2qm74	5113	3	potentiated	potentiate	VBD
cord-015021-pol2qm74	5113	4	the	the	DT
cord-015021-pol2qm74	5113	5	postischemic	postischemic	NNP
cord-015021-pol2qm74	5113	6	liver	liver	NN
cord-015021-pol2qm74	5113	7	injury	injury	NN
cord-015021-pol2qm74	5113	8	as	as	IN
cord-015021-pol2qm74	5113	9	indicated	indicate	VBN
cord-015021-pol2qm74	5113	10	by	by	IN
cord-015021-pol2qm74	5113	11	histopathology	histopathology	NN
cord-015021-pol2qm74	5113	12	and	and	CC
cord-015021-pol2qm74	5113	13	an	an	DT
cord-015021-pol2qm74	5113	14	increase	increase	NN
cord-015021-pol2qm74	5113	15	of	of	IN
cord-015021-pol2qm74	5113	16	plasma	plasma	NN
cord-015021-pol2qm74	5113	17	ALT	alt	NN
cord-015021-pol2qm74	5113	18	activities	activity	NNS
cord-015021-pol2qm74	5113	19	from	from	IN
cord-015021-pol2qm74	5113	20	870	870	CD
cord-015021-pol2qm74	5113	21	+	+	SYM
cord-015021-pol2qm74	5113	22	122	122	CD
cord-015021-pol2qm74	5113	23	U	U	NNP
cord-015021-pol2qm74	5113	24	/	/	SYM
cord-015021-pol2qm74	5113	25	L	l	NN
cord-015021-pol2qm74	5113	26	(	(	-LRB-
cord-015021-pol2qm74	5113	27	I	i	NN
cord-015021-pol2qm74	5113	28	/	/	SYM
cord-015021-pol2qm74	5113	29	RP	RP	NNP
cord-015021-pol2qm74	5113	30	only	only	RB
cord-015021-pol2qm74	5113	31	)	)	-RRB-
cord-015021-pol2qm74	5113	32	to	to	IN
cord-015021-pol2qm74	5113	33	3900	3900	CD
cord-015021-pol2qm74	5113	34	+	+	SYM
cord-015021-pol2qm74	5113	35	470	470	CD
cord-015021-pol2qm74	5113	36	U	U	NNP
cord-015021-pol2qm74	5113	37	/	/	SYM
cord-015021-pol2qm74	5113	38	L	l	NN
cord-015021-pol2qm74	5113	39	at	at	IN
cord-015021-pol2qm74	5113	40	4h	4h	CD
cord-015021-pol2qm74	5113	41	RP	RP	NNP
cord-015021-pol2qm74	5113	42	.	.	.
cord-015021-pol2qm74	5114	1	Inhibition	inhibition	NN
cord-015021-pol2qm74	5114	2	of	of	IN
cord-015021-pol2qm74	5114	3	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5114	4	cells	cell	NNS
cord-015021-pol2qm74	5114	5	(	(	-LRB-
cord-015021-pol2qm74	5114	6	KC	KC	NNP
cord-015021-pol2qm74	5114	7	)	)	-RRB-
cord-015021-pol2qm74	5114	8	with	with	IN
cord-015021-pol2qm74	5114	9	gadolinium	gadolinium	NN
cord-015021-pol2qm74	5114	10	chloride	chloride	NN
cord-015021-pol2qm74	5114	11	(	(	-LRB-
cord-015021-pol2qm74	5114	12	7	7	CD
cord-015021-pol2qm74	5114	13	mg	mg	NNP
cord-015021-pol2qm74	5114	14	/	/	SYM
cord-015021-pol2qm74	5114	15	kg	kg	NNP
cord-015021-pol2qm74	5114	16	)	)	-RRB-
cord-015021-pol2qm74	5114	17	attenuated	attenuated	JJ
cord-015021-pol2qm74	5114	18	liver	liver	NN
cord-015021-pol2qm74	5114	19	injury	injury	NN
cord-015021-pol2qm74	5114	20	in	in	IN
cord-015021-pol2qm74	5114	21	this	this	DT
cord-015021-pol2qm74	5114	22	model	model	NN
cord-015021-pol2qm74	5114	23	by	by	IN
cord-015021-pol2qm74	5114	24	70	70	CD
cord-015021-pol2qm74	5114	25	%	%	NN
cord-015021-pol2qm74	5114	26	,	,	,
cord-015021-pol2qm74	5114	27	however	however	RB
cord-015021-pol2qm74	5114	28	,	,	,
cord-015021-pol2qm74	5114	29	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	5114	30	antibodies	antibody	NNS
cord-015021-pol2qm74	5114	31	(	(	-LRB-
cord-015021-pol2qm74	5114	32	CL26	CL26	NNP
cord-015021-pol2qm74	5114	33	,	,	,
cord-015021-pol2qm74	5114	34	WT3	WT3	NNP
cord-015021-pol2qm74	5114	35	)	)	-RRB-
cord-015021-pol2qm74	5114	36	directed	direct	VBD
cord-015021-pol2qm74	5114	37	against	against	IN
cord-015021-pol2qm74	5114	38	adhesion	adhesion	NN
cord-015021-pol2qm74	5114	39	molecules	molecule	NNS
cord-015021-pol2qm74	5114	40	(	(	-LRB-
cord-015021-pol2qm74	5115	1	132	132	CD
cord-015021-pol2qm74	5115	2	integrins	integrin	NNS
cord-015021-pol2qm74	5115	3	,	,	,
cord-015021-pol2qm74	5115	4	CD18	CD18	NNP
cord-015021-pol2qm74	5115	5	)	)	-RRB-
cord-015021-pol2qm74	5115	6	on	on	IN
cord-015021-pol2qm74	5115	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5115	8	had	have	VBD
cord-015021-pol2qm74	5115	9	no	no	DT
cord-015021-pol2qm74	5115	10	effect	effect	NN
cord-015021-pol2qm74	5115	11	on	on	IN
cord-015021-pol2qm74	5115	12	the	the	DT
cord-015021-pol2qm74	5115	13	injury	injury	NN
cord-015021-pol2qm74	5115	14	despite	despite	IN
cord-015021-pol2qm74	5115	15	the	the	DT
cord-015021-pol2qm74	5115	16	substantial	substantial	JJ
cord-015021-pol2qm74	5115	17	accumulation	accumulation	NN
cord-015021-pol2qm74	5115	18	of	of	IN
cord-015021-pol2qm74	5115	19	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5115	20	in	in	IN
cord-015021-pol2qm74	5115	21	the	the	DT
cord-015021-pol2qm74	5115	22	liver	liver	NN
cord-015021-pol2qm74	5115	23	at	at	IN
cord-015021-pol2qm74	5115	24	that	that	DT
cord-015021-pol2qm74	5115	25	time	time	NN
cord-015021-pol2qm74	5115	26	(	(	-LRB-
cord-015021-pol2qm74	5115	27	467	467	CD
cord-015021-pol2qm74	5115	28	+	+	SYM
cord-015021-pol2qm74	5115	29	52	52	CD
cord-015021-pol2qm74	5115	30	PMNs/50	PMNs/50	NNS
cord-015021-pol2qm74	5115	31	HPF	HPF	NNP
cord-015021-pol2qm74	5115	32	;	;	:
cord-015021-pol2qm74	5115	33	baseline	baseline	NN
cord-015021-pol2qm74	5115	34	:	:	:
cord-015021-pol2qm74	5115	35	13	13	CD
cord-015021-pol2qm74	5115	36	+	+	SYM
cord-015021-pol2qm74	5115	37	3	3	CD
cord-015021-pol2qm74	5115	38	)	)	-RRB-
cord-015021-pol2qm74	5115	39	.	.	.
cord-015021-pol2qm74	5116	1	Isolation	isolation	NN
cord-015021-pol2qm74	5116	2	of	of	IN
cord-015021-pol2qm74	5116	3	KC	KC	NNP
cord-015021-pol2qm74	5116	4	and	and	CC
cord-015021-pol2qm74	5116	5	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5116	6	from	from	IN
cord-015021-pol2qm74	5116	7	the	the	DT
cord-015021-pol2qm74	5116	8	postischemic	postischemic	NNP
cord-015021-pol2qm74	5116	9	liver	liver	NN
cord-015021-pol2qm74	5116	10	indicated	indicate	VBD
cord-015021-pol2qm74	5116	11	a	a	DT
cord-015021-pol2qm74	5116	12	10-fold	10-fold	JJ
cord-015021-pol2qm74	5116	13	increase	increase	NN
cord-015021-pol2qm74	5116	14	of	of	IN
cord-015021-pol2qm74	5116	15	the	the	DT
cord-015021-pol2qm74	5116	16	spontaneous	spontaneous	JJ
cord-015021-pol2qm74	5116	17	superoxide	superoxide	NN
cord-015021-pol2qm74	5116	18	formation	formation	NN
cord-015021-pol2qm74	5116	19	only	only	RB
cord-015021-pol2qm74	5116	20	in	in	IN
cord-015021-pol2qm74	5116	21	the	the	DT
cord-015021-pol2qm74	5116	22	KC	KC	NNP
cord-015021-pol2qm74	5116	23	fractions	fraction	NNS
cord-015021-pol2qm74	5116	24	[	[	-LRB-
cord-015021-pol2qm74	5116	25	3.85	3.85	CD
cord-015021-pol2qm74	5116	26	+	+	SYM
cord-015021-pol2qm74	5116	27	0.68	0.68	CD
cord-015021-pol2qm74	5116	28	nmol	nmol	JJ
cord-015021-pol2qm74	5116	29	O2-/h/10%elts	O2-/h/10%elts	NNP
cord-015021-pol2qm74	5116	30	(	(	-LRB-
cord-015021-pol2qm74	5116	31	KC2	KC2	NNP
cord-015021-pol2qm74	5116	32	)	)	-RRB-
cord-015021-pol2qm74	5116	33	;	;	:
cord-015021-pol2qm74	5116	34	6.82_+0.92	6.82_+0.92	LS
cord-015021-pol2qm74	5116	35	(	(	-LRB-
cord-015021-pol2qm74	5116	36	KCa	KCa	NNS
cord-015021-pol2qm74	5116	37	)	)	-RRB-
cord-015021-pol2qm74	5116	38	]	]	-RRB-
cord-015021-pol2qm74	5116	39	at	at	IN
cord-015021-pol2qm74	5116	40	4h	4h	CD
cord-015021-pol2qm74	5116	41	RP	RP	NNP
cord-015021-pol2qm74	5116	42	compared	compare	VBN
cord-015021-pol2qm74	5116	43	to	to	TO
cord-015021-pol2qm74	5116	44	control	control	NN
cord-015021-pol2qm74	5116	45	cells	cell	NNS
cord-015021-pol2qm74	5116	46	.	.	.
cord-015021-pol2qm74	5117	1	In	in	IN
cord-015021-pol2qm74	5117	2	addition	addition	NN
cord-015021-pol2qm74	5117	3	,	,	,
cord-015021-pol2qm74	5117	4	stimulation	stimulation	NN
cord-015021-pol2qm74	5117	5	with	with	IN
cord-015021-pol2qm74	5117	6	phorbol	phorbol	NNP
cord-015021-pol2qm74	5117	7	ester	ester	NNP
cord-015021-pol2qm74	5117	8	or	or	CC
cord-015021-pol2qm74	5117	9	opsonized	opsonize	VBN
cord-015021-pol2qm74	5117	10	zymosan	zymosan	NNP
cord-015021-pol2qm74	5117	11	revealed	reveal	VBD
cord-015021-pol2qm74	5117	12	a	a	DT
cord-015021-pol2qm74	5117	13	substantial	substantial	JJ
cord-015021-pol2qm74	5117	14	priming	priming	NN
cord-015021-pol2qm74	5117	15	of	of	IN
cord-015021-pol2qm74	5117	16	KC	KC	NNP
cord-015021-pol2qm74	5117	17	for	for	IN
cord-015021-pol2qm74	5117	18	reactive	reactive	JJ
cord-015021-pol2qm74	5117	19	oxygen	oxygen	NN
cord-015021-pol2qm74	5117	20	formation	formation	NN
cord-015021-pol2qm74	5117	21	.	.	.
cord-015021-pol2qm74	5118	1	In	in	IN
cord-015021-pol2qm74	5118	2	contrast	contrast	NN
cord-015021-pol2qm74	5118	3	to	to	IN
cord-015021-pol2qm74	5118	4	the	the	DT
cord-015021-pol2qm74	5118	5	short	short	JJ
cord-015021-pol2qm74	5118	6	-	-	HYPH
cord-015021-pol2qm74	5118	7	term	term	NN
cord-015021-pol2qm74	5118	8	experiments	experiment	NNS
cord-015021-pol2qm74	5118	9	(	(	-LRB-
cord-015021-pol2qm74	5118	10	4h	4h	NNP
cord-015021-pol2qm74	5118	11	)	)	-RRB-
cord-015021-pol2qm74	5118	12	,	,	,
cord-015021-pol2qm74	5118	13	the	the	DT
cord-015021-pol2qm74	5118	14	antibody	antibody	NN
cord-015021-pol2qm74	5118	15	WT3	WT3	NNP
cord-015021-pol2qm74	5118	16	(	(	-LRB-
cord-015021-pol2qm74	5118	17	4	4	CD
cord-015021-pol2qm74	5118	18	mg	mg	NNP
cord-015021-pol2qm74	5118	19	/	/	SYM
cord-015021-pol2qm74	5118	20	kg	kg	NNP
cord-015021-pol2qm74	5118	21	)	)	-RRB-
cord-015021-pol2qm74	5118	22	attenuated	attenuated	JJ
cord-015021-pol2qm74	5118	23	liver	liver	NN
cord-015021-pol2qm74	5118	24	injury	injury	NN
cord-015021-pol2qm74	5118	25	by	by	IN
cord-015021-pol2qm74	5118	26	90	90	CD
cord-015021-pol2qm74	5118	27	%	%	NN
cord-015021-pol2qm74	5118	28	at	at	IN
cord-015021-pol2qm74	5118	29	24	24	CD
cord-015021-pol2qm74	5118	30	h	h	NN
cord-015021-pol2qm74	5118	31	of	of	IN
cord-015021-pol2qm74	5118	32	RP	RP	NNP
cord-015021-pol2qm74	5118	33	and	and	CC
cord-015021-pol2qm74	5118	34	improved	improve	VBN
cord-015021-pol2qm74	5118	35	survival	survival	NN
cord-015021-pol2qm74	5118	36	.	.	.
cord-015021-pol2qm74	5119	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	5119	2	:	:	:
cord-015021-pol2qm74	5120	1	Liver	liver	NN
cord-015021-pol2qm74	5120	2	injury	injury	NN
cord-015021-pol2qm74	5120	3	during	during	IN
cord-015021-pol2qm74	5120	4	the	the	DT
cord-015021-pol2qm74	5120	5	early	early	JJ
cord-015021-pol2qm74	5120	6	RP	rp	NN
cord-015021-pol2qm74	5120	7	phase	phase	NN
cord-015021-pol2qm74	5120	8	is	be	VBZ
cord-015021-pol2qm74	5120	9	mediated	mediate	VBN
cord-015021-pol2qm74	5120	10	mainly	mainly	RB
cord-015021-pol2qm74	5120	11	by	by	IN
cord-015021-pol2qm74	5120	12	KC	KC	NNP
cord-015021-pol2qm74	5120	13	generating	generate	VBG
cord-015021-pol2qm74	5120	14	excessive	excessive	JJ
cord-015021-pol2qm74	5120	15	amounts	amount	NNS
cord-015021-pol2qm74	5120	16	of	of	IN
cord-015021-pol2qm74	5120	17	reactive	reactive	JJ
cord-015021-pol2qm74	5120	18	oxygen	oxygen	NN
cord-015021-pol2qm74	5120	19	while	while	IN
cord-015021-pol2qm74	5120	20	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5120	21	are	be	VBP
cord-015021-pol2qm74	5120	22	primarily	primarily	RB
cord-015021-pol2qm74	5120	23	responsible	responsible	JJ
cord-015021-pol2qm74	5120	24	for	for	IN
cord-015021-pol2qm74	5120	25	organ	organ	NN
cord-015021-pol2qm74	5120	26	damage	damage	NN
cord-015021-pol2qm74	5120	27	during	during	IN
cord-015021-pol2qm74	5120	28	the	the	DT
cord-015021-pol2qm74	5120	29	later	later	JJ
cord-015021-pol2qm74	5120	30	RP	rp	NN
cord-015021-pol2qm74	5120	31	period	period	NN
cord-015021-pol2qm74	5120	32	.	.	.
cord-015021-pol2qm74	5121	1	(	(	-LRB-
cord-015021-pol2qm74	5121	2	ES-06091	es-06091	NN
cord-015021-pol2qm74	5121	3	and	and	CC
cord-015021-pol2qm74	5121	4	GM-42957	GM-42957	NNP
cord-015021-pol2qm74	5121	5	)	)	-RRB-
cord-015021-pol2qm74	5121	6	 	 	_SP
cord-015021-pol2qm74	5122	1	Tumor	tumor	NN
cord-015021-pol2qm74	5122	2	necrosis	necrosis	NN
cord-015021-pol2qm74	5122	3	factors	factor	NNS
cord-015021-pol2qm74	5122	4	(	(	-LRB-
cord-015021-pol2qm74	5122	5	TNF	TNF	NNP
cord-015021-pol2qm74	5122	6	)	)	-RRB-
cord-015021-pol2qm74	5122	7	are	be	VBP
cord-015021-pol2qm74	5122	8	cytokines	cytokine	NNS
cord-015021-pol2qm74	5122	9	which	which	WDT
cord-015021-pol2qm74	5122	10	are	be	VBP
cord-015021-pol2qm74	5122	11	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	5122	12	towards	towards	IN
cord-015021-pol2qm74	5122	13	some	some	DT
cord-015021-pol2qm74	5122	14	tumors	tumor	NNS
cord-015021-pol2qm74	5122	15	in	in	IN
cord-015021-pol2qm74	5122	16	vivo	vivo	NN
cord-015021-pol2qm74	5122	17	and	and	CC
cord-015021-pol2qm74	5122	18	certain	certain	JJ
cord-015021-pol2qm74	5122	19	tumor	tumor	NN
cord-015021-pol2qm74	5122	20	lines	line	NNS
cord-015021-pol2qm74	5122	21	in	in	IN
cord-015021-pol2qm74	5122	22	vitro	vitro	FW
cord-015021-pol2qm74	5122	23	.	.	.
cord-015021-pol2qm74	5123	1	Moreover	moreover	RB
cord-015021-pol2qm74	5123	2	,	,	,
cord-015021-pol2qm74	5123	3	these	these	DT
cord-015021-pol2qm74	5123	4	polypeptides	polypeptide	NNS
cord-015021-pol2qm74	5123	5	are	be	VBP
cord-015021-pol2qm74	5123	6	powerful	powerful	JJ
cord-015021-pol2qm74	5123	7	immunomodulators	immunomodulator	NNS
cord-015021-pol2qm74	5123	8	and	and	CC
cord-015021-pol2qm74	5123	9	have	have	VBP
cord-015021-pol2qm74	5123	10	been	be	VBN
cord-015021-pol2qm74	5123	11	found	find	VBN
cord-015021-pol2qm74	5123	12	to	to	TO
cord-015021-pol2qm74	5123	13	be	be	VB
cord-015021-pol2qm74	5123	14	distal	distal	JJ
cord-015021-pol2qm74	5123	15	mediators	mediator	NNS
cord-015021-pol2qm74	5123	16	in	in	IN
cord-015021-pol2qm74	5123	17	several	several	JJ
cord-015021-pol2qm74	5123	18	models	model	NNS
cord-015021-pol2qm74	5123	19	of	of	IN
cord-015021-pol2qm74	5123	20	septic	septic	JJ
cord-015021-pol2qm74	5123	21	shock	shock	NN
cord-015021-pol2qm74	5123	22	and	and	CC
cord-015021-pol2qm74	5123	23	septic	septic	JJ
cord-015021-pol2qm74	5123	24	organ	organ	NN
cord-015021-pol2qm74	5123	25	failure	failure	NN
cord-015021-pol2qm74	5123	26	.	.	.
cord-015021-pol2qm74	5124	1	One	one	CD
cord-015021-pol2qm74	5124	2	of	of	IN
cord-015021-pol2qm74	5124	3	the	the	DT
cord-015021-pol2qm74	5124	4	best	well	RBS
cord-015021-pol2qm74	5124	5	-	-	HYPH
cord-015021-pol2qm74	5124	6	characterized	characterize	VBN
cord-015021-pol2qm74	5124	7	experimental	experimental	JJ
cord-015021-pol2qm74	5124	8	systems	system	NNS
cord-015021-pol2qm74	5124	9	is	be	VBZ
cord-015021-pol2qm74	5124	10	the	the	DT
cord-015021-pol2qm74	5124	11	hepatitis	hepatitis	NN
cord-015021-pol2qm74	5124	12	caused	cause	VBN
cord-015021-pol2qm74	5124	13	by	by	IN
cord-015021-pol2qm74	5124	14	LPS	LPS	NNP
cord-015021-pol2qm74	5124	15	or	or	CC
cord-015021-pol2qm74	5124	16	TNF	TNF	NNP
cord-015021-pol2qm74	5124	17	in	in	IN
cord-015021-pol2qm74	5124	18	galactosamine	galactosamine	NNP
cord-015021-pol2qm74	5124	19	(	(	-LRB-
cord-015021-pol2qm74	5124	20	GalN)-sensitized	galn)-sensitize	VBN
cord-015021-pol2qm74	5124	21	mice	mouse	NNS
cord-015021-pol2qm74	5124	22	.	.	.
cord-015021-pol2qm74	5125	1	Here	here	RB
cord-015021-pol2qm74	5125	2	we	-PRON-	PRP
cord-015021-pol2qm74	5125	3	describe	describe	VBP
cord-015021-pol2qm74	5125	4	a	a	DT
cord-015021-pol2qm74	5125	5	cell	cell	NN
cord-015021-pol2qm74	5125	6	culture	culture	NN
cord-015021-pol2qm74	5125	7	system	system	NN
cord-015021-pol2qm74	5125	8	,	,	,
cord-015021-pol2qm74	5125	9	in	in	IN
cord-015021-pol2qm74	5125	10	which	which	WDT
cord-015021-pol2qm74	5125	11	the	the	DT
cord-015021-pol2qm74	5125	12	direct	direct	JJ
cord-015021-pol2qm74	5125	13	toxicity	toxicity	NN
cord-015021-pol2qm74	5125	14	of	of	IN
cord-015021-pol2qm74	5125	15	TNF	TNF	NNP
cord-015021-pol2qm74	5125	16	towards	towards	IN
cord-015021-pol2qm74	5125	17	mouse	mouse	NN
cord-015021-pol2qm74	5125	18	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5125	19	was	be	VBD
cord-015021-pol2qm74	5125	20	examined	examine	VBN
cord-015021-pol2qm74	5125	21	.	.	.
cord-015021-pol2qm74	5126	1	The	the	DT
cord-015021-pol2qm74	5126	2	toxicity	toxicity	NN
cord-015021-pol2qm74	5126	3	of	of	IN
cord-015021-pol2qm74	5126	4	TNF	TNF	NNP
cord-015021-pol2qm74	5126	5	,	,	,
cord-015021-pol2qm74	5126	6	as	as	IN
cord-015021-pol2qm74	5126	7	determined	determine	VBN
cord-015021-pol2qm74	5126	8	by	by	IN
cord-015021-pol2qm74	5126	9	LDH	LDH	NNP
cord-015021-pol2qm74	5126	10	-	-	HYPH
cord-015021-pol2qm74	5126	11	release	release	NN
cord-015021-pol2qm74	5126	12	or	or	CC
cord-015021-pol2qm74	5126	13	formazan	formazan	NN
cord-015021-pol2qm74	5126	14	-	-	NN
cord-015021-pol2qm74	5126	15	formation	formation	NN
cord-015021-pol2qm74	5126	16	,	,	,
cord-015021-pol2qm74	5126	17	was	be	VBD
cord-015021-pol2qm74	5126	18	dose	dose	NN
cord-015021-pol2qm74	5126	19	-	-	HYPH
cord-015021-pol2qm74	5126	20	and	and	CC
cord-015021-pol2qm74	5126	21	time	time	NN
cord-015021-pol2qm74	5126	22	-	-	HYPH
cord-015021-pol2qm74	5126	23	dependent	dependent	JJ
cord-015021-pol2qm74	5126	24	.	.	.
cord-015021-pol2qm74	5127	1	The	the	DT
cord-015021-pol2qm74	5127	2	threshold	threshold	NN
cord-015021-pol2qm74	5127	3	of	of	IN
cord-015021-pol2qm74	5127	4	toxicity	toxicity	NN
cord-015021-pol2qm74	5127	5	was	be	VBD
cord-015021-pol2qm74	5127	6	10	10	CD
cord-015021-pol2qm74	5127	7	ng	ng	NN
cord-015021-pol2qm74	5127	8	/	/	SYM
cord-015021-pol2qm74	5127	9	ml	ml	NN
cord-015021-pol2qm74	5127	10	,	,	,
cord-015021-pol2qm74	5127	11	which	which	WDT
cord-015021-pol2qm74	5127	12	corresponds	correspond	VBZ
cord-015021-pol2qm74	5127	13	to	to	IN
cord-015021-pol2qm74	5127	14	serum	serum	NN
cord-015021-pol2qm74	5127	15	concentrations	concentration	NNS
cord-015021-pol2qm74	5127	16	found	find	VBN
cord-015021-pol2qm74	5127	17	in	in	IN
cord-015021-pol2qm74	5127	18	mice	mouse	NNS
cord-015021-pol2qm74	5127	19	after	after	IN
cord-015021-pol2qm74	5127	20	LPSinjection	lpsinjection	NN
cord-015021-pol2qm74	5127	21	.	.	.
cord-015021-pol2qm74	5128	1	Toxicity	toxicity	NN
cord-015021-pol2qm74	5128	2	was	be	VBD
cord-015021-pol2qm74	5128	3	only	only	RB
cord-015021-pol2qm74	5128	4	observed	observe	VBN
cord-015021-pol2qm74	5128	5	in	in	IN
cord-015021-pol2qm74	5128	6	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5128	7	sensitized	sensitize	VBN
cord-015021-pol2qm74	5128	8	with	with	IN
cord-015021-pol2qm74	5128	9	transcriptional	transcriptional	JJ
cord-015021-pol2qm74	5128	10	inhibiters	inhibiter	NNS
cord-015021-pol2qm74	5128	11	such	such	JJ
cord-015021-pol2qm74	5128	12	as	as	IN
cord-015021-pol2qm74	5128	13	GalN	GalN	NNP
cord-015021-pol2qm74	5128	14	,	,	,
cord-015021-pol2qm74	5128	15	actinomycin	actinomycin	NNS
cord-015021-pol2qm74	5128	16	D	D	NNP
cord-015021-pol2qm74	5128	17	(	(	-LRB-
cord-015021-pol2qm74	5128	18	ActD	ActD	NNP
cord-015021-pol2qm74	5128	19	)	)	-RRB-
cord-015021-pol2qm74	5128	20	or	or	CC
cord-015021-pol2qm74	5128	21	cxamanitin	cxamanitin	NNP
cord-015021-pol2qm74	5128	22	.	.	.
cord-015021-pol2qm74	5129	1	Sensitization	sensitization	NN
cord-015021-pol2qm74	5129	2	was	be	VBD
cord-015021-pol2qm74	5129	3	neither	neither	CC
cord-015021-pol2qm74	5129	4	observed	observe	VBN
cord-015021-pol2qm74	5129	5	with	with	IN
cord-015021-pol2qm74	5129	6	different	different	JJ
cord-015021-pol2qm74	5129	7	translational	translational	JJ
cord-015021-pol2qm74	5129	8	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5129	9	nor	nor	CC
cord-015021-pol2qm74	5129	10	with	with	IN
cord-015021-pol2qm74	5129	11	various	various	JJ
cord-015021-pol2qm74	5129	12	other	other	JJ
cord-015021-pol2qm74	5129	13	metabolic	metabolic	JJ
cord-015021-pol2qm74	5129	14	inlaibitors	inlaibitor	NNS
cord-015021-pol2qm74	5129	15	or	or	CC
cord-015021-pol2qm74	5129	16	toxins	toxin	NNS
cord-015021-pol2qm74	5129	17	.	.	.
cord-015021-pol2qm74	5130	1	Inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5130	2	of	of	IN
cord-015021-pol2qm74	5130	3	protein	protein	NN
cord-015021-pol2qm74	5130	4	synthesis	synthesis	NN
cord-015021-pol2qm74	5130	5	or	or	CC
cord-015021-pol2qm74	5130	6	protein	protein	NN
cord-015021-pol2qm74	5130	7	processing	processing	NN
cord-015021-pol2qm74	5130	8	such	such	JJ
cord-015021-pol2qm74	5130	9	as	as	IN
cord-015021-pol2qm74	5130	10	cycloheximide	cycloheximide	NN
cord-015021-pol2qm74	5130	11	,	,	,
cord-015021-pol2qm74	5130	12	puromycin	puromycin	NNS
cord-015021-pol2qm74	5130	13	,	,	,
cord-015021-pol2qm74	5130	14	tunicamycin	tunicamycin	NNS
cord-015021-pol2qm74	5130	15	and	and	CC
cord-015021-pol2qm74	5130	16	ricin	ricin	NN
cord-015021-pol2qm74	5130	17	protected	protect	VBN
cord-015021-pol2qm74	5130	18	ActDsensitized	ActDsensitized	NNP
cord-015021-pol2qm74	5130	19	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5130	20	from	from	IN
cord-015021-pol2qm74	5130	21	TNF	tnf	NN
cord-015021-pol2qm74	5130	22	-	-	HYPH
cord-015021-pol2qm74	5130	23	induced	induce	VBN
cord-015021-pol2qm74	5130	24	cytotoxicity	cytotoxicity	NN
cord-015021-pol2qm74	5130	25	.	.	.
cord-015021-pol2qm74	5131	1	TNF	TNF	NNP
cord-015021-pol2qm74	5131	2	induced	induce	VBD
cord-015021-pol2qm74	5131	3	apoptotic	apoptotic	JJ
cord-015021-pol2qm74	5131	4	changes	change	NNS
cord-015021-pol2qm74	5131	5	and	and	CC
cord-015021-pol2qm74	5131	6	DNA	dna	NN
cord-015021-pol2qm74	5131	7	-	-	HYPH
cord-015021-pol2qm74	5131	8	fragmentation	fragmentation	NN
cord-015021-pol2qm74	5131	9	in	in	IN
cord-015021-pol2qm74	5131	10	sensitized	sensitized	JJ
cord-015021-pol2qm74	5131	11	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5131	12	which	which	WDT
cord-015021-pol2qm74	5131	13	is	be	VBZ
cord-015021-pol2qm74	5131	14	in	in	IN
cord-015021-pol2qm74	5131	15	line	line	NN
cord-015021-pol2qm74	5131	16	with	with	IN
cord-015021-pol2qm74	5131	17	the	the	DT
cord-015021-pol2qm74	5131	18	above	above	JJ
cord-015021-pol2qm74	5131	19	findings	finding	NNS
cord-015021-pol2qm74	5131	20	that	that	IN
cord-015021-pol2qm74	5131	21	cell	cell	NN
cord-015021-pol2qm74	5131	22	death	death	NN
cord-015021-pol2qm74	5131	23	is	be	VBZ
cord-015021-pol2qm74	5131	24	dependent	dependent	JJ
cord-015021-pol2qm74	5131	25	on	on	IN
cord-015021-pol2qm74	5131	26	protein	protein	NN
cord-015021-pol2qm74	5131	27	synthesis	synthesis	NN
cord-015021-pol2qm74	5131	28	.	.	.
cord-015021-pol2qm74	5132	1	Thus	thus	RB
cord-015021-pol2qm74	5132	2	TNF	TNF	NNP
cord-015021-pol2qm74	5132	3	may	may	MD
cord-015021-pol2qm74	5132	4	be	be	VB
cord-015021-pol2qm74	5132	5	a	a	DT
cord-015021-pol2qm74	5132	6	trigger	trigger	NN
cord-015021-pol2qm74	5132	7	of	of	IN
cord-015021-pol2qm74	5132	8	programmed	programmed	JJ
cord-015021-pol2qm74	5132	9	cell	cell	NN
cord-015021-pol2qm74	5132	10	death	death	NN
cord-015021-pol2qm74	5132	11	during	during	IN
cord-015021-pol2qm74	5132	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5132	13	organ	organ	NN
cord-015021-pol2qm74	5132	14	damage	damage	NN
cord-015021-pol2qm74	5132	15	.	.	.
cord-015021-pol2qm74	5133	1	With	with	IN
cord-015021-pol2qm74	5133	2	the	the	DT
cord-015021-pol2qm74	5133	3	purpose	purpose	NN
cord-015021-pol2qm74	5133	4	of	of	IN
cord-015021-pol2qm74	5133	5	studying	study	VBG
cord-015021-pol2qm74	5133	6	the	the	DT
cord-015021-pol2qm74	5133	7	role	role	NN
cord-015021-pol2qm74	5133	8	of	of	IN
cord-015021-pol2qm74	5133	9	complement	complement	JJ
cord-015021-pol2qm74	5133	10	activation	activation	NN
cord-015021-pol2qm74	5133	11	in	in	IN
cord-015021-pol2qm74	5133	12	tissue	tissue	NN
cord-015021-pol2qm74	5133	13	injury	injury	NN
cord-015021-pol2qm74	5133	14	after	after	IN
cord-015021-pol2qm74	5133	15	ischaemia	ischaemia	NN
cord-015021-pol2qm74	5133	16	and	and	CC
cord-015021-pol2qm74	5133	17	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5133	18	we	-PRON-	PRP
cord-015021-pol2qm74	5133	19	blocked	block	VBD
cord-015021-pol2qm74	5133	20	the	the	DT
cord-015021-pol2qm74	5133	21	complement	complement	NN
cord-015021-pol2qm74	5133	22	cascade	cascade	NN
cord-015021-pol2qm74	5133	23	in	in	IN
cord-015021-pol2qm74	5133	24	a	a	DT
cord-015021-pol2qm74	5133	25	model	model	NN
cord-015021-pol2qm74	5133	26	of	of	IN
cord-015021-pol2qm74	5133	27	rat	rat	NN
cord-015021-pol2qm74	5133	28	liver	liver	NN
cord-015021-pol2qm74	5133	29	isehaemia	isehaemia	NN
cord-015021-pol2qm74	5133	30	and	and	CC
cord-015021-pol2qm74	5133	31	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5133	32	,	,	,
cord-015021-pol2qm74	5133	33	either	either	CC
cord-015021-pol2qm74	5133	34	by	by	IN
cord-015021-pol2qm74	5133	35	administration	administration	NN
cord-015021-pol2qm74	5133	36	of	of	IN
cord-015021-pol2qm74	5133	37	Soluble	Soluble	NNP
cord-015021-pol2qm74	5133	38	Human	Human	NNP
cord-015021-pol2qm74	5133	39	Complement	Complement	NNP
cord-015021-pol2qm74	5133	40	Receptor	Receptor	NNP
cord-015021-pol2qm74	5133	41	Type	Type	NNP
cord-015021-pol2qm74	5133	42	1	1	CD
cord-015021-pol2qm74	5133	43	(	(	-LRB-
cord-015021-pol2qm74	5133	44	sCRI	scri	NN
cord-015021-pol2qm74	5133	45	)	)	-RRB-
cord-015021-pol2qm74	5133	46	,	,	,
cord-015021-pol2qm74	5133	47	25	25	CD
cord-015021-pol2qm74	5133	48	mg	mg	NNP
cord-015021-pol2qm74	5133	49	/	/	SYM
cord-015021-pol2qm74	5133	50	Kg	Kg	NNP
cord-015021-pol2qm74	5133	51	IV	IV	NNP
cord-015021-pol2qm74	5133	52	after	after	IN
cord-015021-pol2qm74	5133	53	vascular	vascular	JJ
cord-015021-pol2qm74	5133	54	occlusion	occlusion	NN
cord-015021-pol2qm74	5133	55	(	(	-LRB-
cord-015021-pol2qm74	5133	56	n=8	n=8	NN
cord-015021-pol2qm74	5133	57	)	)	-RRB-
cord-015021-pol2qm74	5133	58	or	or	CC
cord-015021-pol2qm74	5133	59	by	by	IN
cord-015021-pol2qm74	5133	60	depleting	deplete	VBG
cord-015021-pol2qm74	5133	61	the	the	DT
cord-015021-pol2qm74	5133	62	complement	complement	NN
cord-015021-pol2qm74	5133	63	system	system	NN
cord-015021-pol2qm74	5133	64	using	use	VBG
cord-015021-pol2qm74	5133	65	Cobra	Cobra	NNP
cord-015021-pol2qm74	5133	66	Venom	Venom	NNP
cord-015021-pol2qm74	5133	67	Factor	factor	NN
cord-015021-pol2qm74	5133	68	(	(	-LRB-
cord-015021-pol2qm74	5133	69	CVF	CVF	NNP
cord-015021-pol2qm74	5133	70	)	)	-RRB-
cord-015021-pol2qm74	5134	1	,	,	,
cord-015021-pol2qm74	5134	2	0.5	0.5	CD
cord-015021-pol2qm74	5134	3	mg	mg	NN
cord-015021-pol2qm74	5134	4	IM	IM	NNP
cord-015021-pol2qm74	5134	5	,	,	,
cord-015021-pol2qm74	5134	6	24	24	CD
cord-015021-pol2qm74	5134	7	and	and	CC
cord-015021-pol2qm74	5134	8	6	6	CD
cord-015021-pol2qm74	5134	9	hours	hour	NNS
cord-015021-pol2qm74	5134	10	before	before	IN
cord-015021-pol2qm74	5134	11	ischaemia	ischaemia	NN
cord-015021-pol2qm74	5134	12	(	(	-LRB-
cord-015021-pol2qm74	5134	13	n=10	n=10	NNP
cord-015021-pol2qm74	5134	14	)	)	-RRB-
cord-015021-pol2qm74	5134	15	.	.	.
cord-015021-pol2qm74	5135	1	Non	non	JJ
cord-015021-pol2qm74	5135	2	-	-	JJ
cord-015021-pol2qm74	5135	3	ischaemic	ischaemic	JJ
cord-015021-pol2qm74	5135	4	rats	rat	NNS
cord-015021-pol2qm74	5135	5	(	(	-LRB-
cord-015021-pol2qm74	5135	6	n=8	n=8	NN
cord-015021-pol2qm74	5135	7	)	)	-RRB-
cord-015021-pol2qm74	5135	8	and	and	CC
cord-015021-pol2qm74	5135	9	ischaemic	ischaemic	JJ
cord-015021-pol2qm74	5135	10	non	non	JJ
cord-015021-pol2qm74	5135	11	-	-	JJ
cord-015021-pol2qm74	5135	12	treated	treat	VBN
cord-015021-pol2qm74	5135	13	rats	rat	NNS
cord-015021-pol2qm74	5135	14	(	(	-LRB-
cord-015021-pol2qm74	5135	15	n=15	n=15	NNP
cord-015021-pol2qm74	5135	16	)	)	-RRB-
cord-015021-pol2qm74	5135	17	were	be	VBD
cord-015021-pol2qm74	5135	18	used	use	VBN
cord-015021-pol2qm74	5135	19	as	as	IN
cord-015021-pol2qm74	5135	20	controls	control	NNS
cord-015021-pol2qm74	5135	21	.	.	.
cord-015021-pol2qm74	5136	1	The	the	DT
cord-015021-pol2qm74	5136	2	experimental	experimental	JJ
cord-015021-pol2qm74	5136	3	procedure	procedure	NN
cord-015021-pol2qm74	5136	4	consists	consist	VBZ
cord-015021-pol2qm74	5136	5	of	of	IN
cord-015021-pol2qm74	5136	6	the	the	DT
cord-015021-pol2qm74	5136	7	temporary	temporary	JJ
cord-015021-pol2qm74	5136	8	interruption	interruption	NN
cord-015021-pol2qm74	5136	9	of	of	IN
cord-015021-pol2qm74	5136	10	arterial	arterial	JJ
cord-015021-pol2qm74	5136	11	and	and	CC
cord-015021-pol2qm74	5136	12	portal	portal	JJ
cord-015021-pol2qm74	5136	13	blood	blood	NN
cord-015021-pol2qm74	5136	14	flow	flow	NN
cord-015021-pol2qm74	5136	15	to	to	IN
cord-015021-pol2qm74	5136	16	the	the	DT
cord-015021-pol2qm74	5136	17	left	left	JJ
cord-015021-pol2qm74	5136	18	lateral	lateral	JJ
cord-015021-pol2qm74	5136	19	and	and	CC
cord-015021-pol2qm74	5136	20	medial	medial	JJ
cord-015021-pol2qm74	5136	21	lobes	lobe	NNS
cord-015021-pol2qm74	5136	22	of	of	IN
cord-015021-pol2qm74	5136	23	the	the	DT
cord-015021-pol2qm74	5136	24	liver	liver	NN
cord-015021-pol2qm74	5136	25	during	during	IN
cord-015021-pol2qm74	5136	26	45	45	CD
cord-015021-pol2qm74	5136	27	minutes	minute	NNS
cord-015021-pol2qm74	5136	28	,	,	,
cord-015021-pol2qm74	5136	29	followed	follow	VBN
cord-015021-pol2qm74	5136	30	by	by	IN
cord-015021-pol2qm74	5136	31	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5136	32	,	,	,
cord-015021-pol2qm74	5136	33	recording	record	VBG
cord-015021-pol2qm74	5136	34	the	the	DT
cord-015021-pol2qm74	5136	35	liver	liver	NN
cord-015021-pol2qm74	5136	36	blood	blood	NN
cord-015021-pol2qm74	5136	37	flow	flow	NN
cord-015021-pol2qm74	5136	38	and	and	CC
cord-015021-pol2qm74	5136	39	haemoglobin	haemoglobin	NN
cord-015021-pol2qm74	5136	40	saturation	saturation	NN
cord-015021-pol2qm74	5136	41	with	with	IN
cord-015021-pol2qm74	5136	42	a	a	DT
cord-015021-pol2qm74	5136	43	Laser	Laser	NNP
cord-015021-pol2qm74	5136	44	Doppler	Doppler	NNP
cord-015021-pol2qm74	5136	45	Flowmeter	Flowmeter	NNP
cord-015021-pol2qm74	5136	46	and	and	CC
cord-015021-pol2qm74	5136	47	Photometer	Photometer	NNP
cord-015021-pol2qm74	5136	48	during	during	IN
cord-015021-pol2qm74	5136	49	one	one	CD
cord-015021-pol2qm74	5136	50	hour	hour	NN
cord-015021-pol2qm74	5136	51	after	after	IN
cord-015021-pol2qm74	5136	52	declamping	declampe	VBG
cord-015021-pol2qm74	5136	53	;	;	:
cord-015021-pol2qm74	5136	54	ALT	alt	NN
cord-015021-pol2qm74	5136	55	levels	level	NNS
cord-015021-pol2qm74	5136	56	were	be	VBD
cord-015021-pol2qm74	5136	57	assayed	assay	VBN
cord-015021-pol2qm74	5136	58	and	and	CC
cord-015021-pol2qm74	5136	59	immunoperoxidase	immunoperoxidase	NN
cord-015021-pol2qm74	5136	60	stainings	staining	NNS
cord-015021-pol2qm74	5136	61	for	for	IN
cord-015021-pol2qm74	5136	62	C3	C3	NNP
cord-015021-pol2qm74	5136	63	and	and	CC
cord-015021-pol2qm74	5136	64	C9	C9	NNP
cord-015021-pol2qm74	5136	65	were	be	VBD
cord-015021-pol2qm74	5136	66	performed	perform	VBN
cord-015021-pol2qm74	5136	67	.	.	.
cord-015021-pol2qm74	5137	1	There	there	EX
cord-015021-pol2qm74	5137	2	were	be	VBD
cord-015021-pol2qm74	5137	3	statistically	statistically	RB
cord-015021-pol2qm74	5137	4	significant	significant	JJ
cord-015021-pol2qm74	5137	5	differences	difference	NNS
cord-015021-pol2qm74	5137	6	between	between	IN
cord-015021-pol2qm74	5137	7	the	the	DT
cord-015021-pol2qm74	5137	8	experimental	experimental	JJ
cord-015021-pol2qm74	5137	9	~roups	~roups	NNP
cord-015021-pol2qm74	5137	10	and	and	CC
cord-015021-pol2qm74	5137	11	the	the	DT
cord-015021-pol2qm74	5137	12	untreated	untreated	JJ
cord-015021-pol2qm74	5137	13	ischaemic	ischaemic	JJ
cord-015021-pol2qm74	5137	14	control	control	NN
cord-015021-pol2qm74	5137	15	group	group	NN
cord-015021-pol2qm74	5137	16	in	in	IN
cord-015021-pol2qm74	5137	17	terms	term	NNS
cord-015021-pol2qm74	5137	18	of	of	IN
cord-015021-pol2qm74	5137	19	post	post	JJ
cord-015021-pol2qm74	5137	20	-	-	JJ
cord-015021-pol2qm74	5137	21	isehaemic	isehaemic	JJ
cord-015021-pol2qm74	5137	22	blood	blood	NN
cord-015021-pol2qm74	5137	23	flow	flow	NN
cord-015021-pol2qm74	5137	24	(	(	-LRB-
cord-015021-pol2qm74	5137	25	p<0.001	p<0.001	JJ
cord-015021-pol2qm74	5137	26	)	)	-RRB-
cord-015021-pol2qm74	5137	27	and	and	CC
cord-015021-pol2qm74	5137	28	haemoglobin	haemoglobin	NN
cord-015021-pol2qm74	5137	29	saturation	saturation	NN
cord-015021-pol2qm74	5137	30	(	(	-LRB-
cord-015021-pol2qm74	5137	31	p<0.001	p<0.001	CD
cord-015021-pol2qm74	5137	32	)	)	-RRB-
cord-015021-pol2qm74	5137	33	.	.	.
cord-015021-pol2qm74	5138	1	C3	C3	NNP
cord-015021-pol2qm74	5138	2	and	and	CC
cord-015021-pol2qm74	5138	3	C9	C9	NNP
cord-015021-pol2qm74	5138	4	were	be	VBD
cord-015021-pol2qm74	5138	5	present	present	JJ
cord-015021-pol2qm74	5138	6	in	in	IN
cord-015021-pol2qm74	5138	7	the	the	DT
cord-015021-pol2qm74	5138	8	endothelium	endothelium	NN
cord-015021-pol2qm74	5138	9	of	of	IN
cord-015021-pol2qm74	5138	10	the	the	DT
cord-015021-pol2qm74	5138	11	ischaemic	ischaemic	NNP
cord-015021-pol2qm74	5138	12	control	control	NN
cord-015021-pol2qm74	5138	13	group	group	NN
cord-015021-pol2qm74	5138	14	.	.	.
cord-015021-pol2qm74	5139	1	No	no	DT
cord-015021-pol2qm74	5139	2	deposits	deposit	NNS
cord-015021-pol2qm74	5139	3	of	of	IN
cord-015021-pol2qm74	5139	4	C3	C3	NNP
cord-015021-pol2qm74	5139	5	or	or	CC
cord-015021-pol2qm74	5139	6	C9	C9	NNP
cord-015021-pol2qm74	5139	7	were	be	VBD
cord-015021-pol2qm74	5139	8	found	find	VBN
cord-015021-pol2qm74	5139	9	in	in	IN
cord-015021-pol2qm74	5139	10	the	the	DT
cord-015021-pol2qm74	5139	11	CVF	CVF	NNP
cord-015021-pol2qm74	5139	12	group	group	NN
cord-015021-pol2qm74	5139	13	.	.	.
cord-015021-pol2qm74	5140	1	Few	few	JJ
cord-015021-pol2qm74	5140	2	C3	c3	NN
cord-015021-pol2qm74	5140	3	and	and	CC
cord-015021-pol2qm74	5140	4	no	no	DT
cord-015021-pol2qm74	5140	5	C9	C9	NNP
cord-015021-pol2qm74	5140	6	were	be	VBD
cord-015021-pol2qm74	5140	7	found	find	VBN
cord-015021-pol2qm74	5140	8	in	in	IN
cord-015021-pol2qm74	5140	9	sCRI	sCRI	VBG
cord-015021-pol2qm74	5140	10	treated	treat	VBN
cord-015021-pol2qm74	5140	11	rats	rat	NNS
cord-015021-pol2qm74	5140	12	.	.	.
cord-015021-pol2qm74	5141	1	These	these	DT
cord-015021-pol2qm74	5141	2	results	result	NNS
cord-015021-pol2qm74	5141	3	show	show	VBP
cord-015021-pol2qm74	5141	4	that	that	IN
cord-015021-pol2qm74	5141	5	the	the	DT
cord-015021-pol2qm74	5141	6	effect	effect	NN
cord-015021-pol2qm74	5141	7	of	of	IN
cord-015021-pol2qm74	5141	8	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5141	9	injury	injury	NN
cord-015021-pol2qm74	5141	10	in	in	IN
cord-015021-pol2qm74	5141	11	the	the	DT
cord-015021-pol2qm74	5141	12	rat	rat	NN
cord-015021-pol2qm74	5141	13	liver	liver	NN
cord-015021-pol2qm74	5141	14	is	be	VBZ
cord-015021-pol2qm74	5141	15	ameliorated	ameliorate	VBN
cord-015021-pol2qm74	5141	16	either	either	CC
cord-015021-pol2qm74	5141	17	by	by	IN
cord-015021-pol2qm74	5141	18	depleting	deplete	VBG
cord-015021-pol2qm74	5141	19	complement	complement	NN
cord-015021-pol2qm74	5141	20	with	with	IN
cord-015021-pol2qm74	5141	21	CVF	CVF	NNP
cord-015021-pol2qm74	5141	22	or	or	CC
cord-015021-pol2qm74	5141	23	by	by	IN
cord-015021-pol2qm74	5141	24	regulating	regulate	VBG
cord-015021-pol2qm74	5141	25	complement	complement	NN
cord-015021-pol2qm74	5141	26	activation	activation	NN
cord-015021-pol2qm74	5141	27	with	with	IN
cord-015021-pol2qm74	5141	28	sCRI	scri	NN
cord-015021-pol2qm74	5141	29	.	.	.
cord-015021-pol2qm74	5142	1	Hepatic	hepatic	JJ
cord-015021-pol2qm74	5142	2	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5142	3	,	,	,
cord-015021-pol2qm74	5142	4	a	a	DT
cord-015021-pol2qm74	5142	5	major	major	JJ
cord-015021-pol2qm74	5142	6	cause	cause	NN
cord-015021-pol2qm74	5142	7	of	of	IN
cord-015021-pol2qm74	5142	8	mortality	mortality	NN
cord-015021-pol2qm74	5142	9	following	follow	VBG
cord-015021-pol2qm74	5142	10	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5142	11	shock	shock	NN
cord-015021-pol2qm74	5142	12	,	,	,
cord-015021-pol2qm74	5142	13	has	have	VBZ
cord-015021-pol2qm74	5142	14	not	not	RB
cord-015021-pol2qm74	5142	15	yet	yet	RB
cord-015021-pol2qm74	5142	16	been	be	VBN
cord-015021-pol2qm74	5142	17	well	well	RB
cord-015021-pol2qm74	5142	18	characterized	characterize	VBN
cord-015021-pol2qm74	5142	19	.	.	.
cord-015021-pol2qm74	5143	1	The	the	DT
cord-015021-pol2qm74	5143	2	present	present	JJ
cord-015021-pol2qm74	5143	3	study	study	NN
cord-015021-pol2qm74	5143	4	was	be	VBD
cord-015021-pol2qm74	5143	5	designed	design	VBN
cord-015021-pol2qm74	5143	6	to	to	TO
cord-015021-pol2qm74	5143	7	assess	assess	VB
cord-015021-pol2qm74	5143	8	the	the	DT
cord-015021-pol2qm74	5143	9	effects	effect	NNS
cord-015021-pol2qm74	5143	10	of	of	IN
cord-015021-pol2qm74	5143	11	liver	liver	NN
cord-015021-pol2qm74	5143	12	blood	blood	NN
cord-015021-pol2qm74	5143	13	flow	flow	NN
cord-015021-pol2qm74	5143	14	and	and	CC
cord-015021-pol2qm74	5143	15	cytokine	cytokine	NN
cord-015021-pol2qm74	5143	16	levels	level	NNS
cord-015021-pol2qm74	5143	17	on	on	IN
cord-015021-pol2qm74	5143	18	hepatic	hepatic	JJ
cord-015021-pol2qm74	5143	19	function	function	NN
cord-015021-pol2qm74	5143	20	following	follow	VBG
cord-015021-pol2qm74	5143	21	resuscitation	resuscitation	NN
cord-015021-pol2qm74	5143	22	from	from	IN
cord-015021-pol2qm74	5143	23	severe	severe	JJ
cord-015021-pol2qm74	5143	24	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5143	25	shock	shock	NN
cord-015021-pol2qm74	5143	26	in	in	IN
cord-015021-pol2qm74	5143	27	normal	normal	JJ
cord-015021-pol2qm74	5143	28	and	and	CC
cord-015021-pol2qm74	5143	29	cin	cin	JJ
cord-015021-pol2qm74	5143	30	-	-	HYPH
cord-015021-pol2qm74	5143	31	hotic	hotic	JJ
cord-015021-pol2qm74	5143	32	rats	rat	NNS
cord-015021-pol2qm74	5143	33	.	.	.
cord-015021-pol2qm74	5144	1	METHODS	methods	NN
cord-015021-pol2qm74	5144	2	:	:	:
cord-015021-pol2qm74	5145	1	Aftor	Aftor	NNP
cord-015021-pol2qm74	5145	2	pentobarbltal	pentobarbltal	JJ
cord-015021-pol2qm74	5145	3	anesthesia	anesthesia	NNP
cord-015021-pol2qm74	5145	4	,	,	,
cord-015021-pol2qm74	5145	5	23	23	CD
cord-015021-pol2qm74	5145	6	control	control	NN
cord-015021-pol2qm74	5145	7	and	and	CC
cord-015021-pol2qm74	5145	8	38	38	CD
cord-015021-pol2qm74	5145	9	cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	5145	10	Sprague	Sprague	NNP
cord-015021-pol2qm74	5145	11	-	-	HYPH
cord-015021-pol2qm74	5145	12	Dawley	Dawley	NNP
cord-015021-pol2qm74	5145	13	rats	rat	NNS
cord-015021-pol2qm74	5145	14	were	be	VBD
cord-015021-pol2qm74	5145	15	subjected	subject	VBN
cord-015021-pol2qm74	5145	16	to	to	IN
cord-015021-pol2qm74	5145	17	severe	severe	JJ
cord-015021-pol2qm74	5145	18	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5145	19	to	to	TO
cord-015021-pol2qm74	5145	20	reduce	reduce	VB
cord-015021-pol2qm74	5145	21	their	-PRON-	PRP$
cord-015021-pol2qm74	5145	22	systolic	systolic	JJ
cord-015021-pol2qm74	5145	23	blood	blood	NN
cord-015021-pol2qm74	5145	24	pressure	pressure	NN
cord-015021-pol2qm74	5145	25	to	to	IN
cord-015021-pol2qm74	5145	26	50	50	CD
cord-015021-pol2qm74	5145	27	+	+	SYM
cord-015021-pol2qm74	5145	28	5	5	CD
cord-015021-pol2qm74	5145	29	mm	mm	NN
cord-015021-pol2qm74	5145	30	Hg	Hg	NNS
cord-015021-pol2qm74	5145	31	.	.	.
cord-015021-pol2qm74	5146	1	This	this	DT
cord-015021-pol2qm74	5146	2	level	level	NN
cord-015021-pol2qm74	5146	3	of	of	IN
cord-015021-pol2qm74	5146	4	hypotension	hypotension	NN
cord-015021-pol2qm74	5146	5	was	be	VBD
cord-015021-pol2qm74	5146	6	maintained	maintain	VBN
cord-015021-pol2qm74	5146	7	until	until	IN
cord-015021-pol2qm74	5146	8	the	the	DT
cord-015021-pol2qm74	5146	9	skeletal	skeletal	JJ
cord-015021-pol2qm74	5146	10	muscle	muscle	NN
cord-015021-pol2qm74	5146	11	transmembrane	transmembrane	NN
cord-015021-pol2qm74	5146	12	potential	potential	NN
cord-015021-pol2qm74	5146	13	(	(	-LRB-
cord-015021-pol2qm74	5146	14	Era	era	NN
cord-015021-pol2qm74	5146	15	)	)	-RRB-
cord-015021-pol2qm74	5146	16	depolarized	depolarize	VBN
cord-015021-pol2qm74	5146	17	by	by	IN
cord-015021-pol2qm74	5146	18	25	25	CD
cord-015021-pol2qm74	5146	19	%	%	NN
cord-015021-pol2qm74	5146	20	.	.	.
cord-015021-pol2qm74	5146	21	;	;	:
cord-015021-pol2qm74	5146	22	the	the	DT
cord-015021-pol2qm74	5146	23	animals	animal	NNS
cord-015021-pol2qm74	5146	24	were	be	VBD
cord-015021-pol2qm74	5146	25	then	then	RB
cord-015021-pol2qm74	5146	26	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	5146	27	with	with	IN
cord-015021-pol2qm74	5146	28	Ringer	Ringer	NNP
cord-015021-pol2qm74	5146	29	's	's	POS
cord-015021-pol2qm74	5146	30	Lactate	Lactate	NNP
cord-015021-pol2qm74	5146	31	solution	solution	NN
cord-015021-pol2qm74	5146	32	in	in	IN
cord-015021-pol2qm74	5146	33	three	three	CD
cord-015021-pol2qm74	5146	34	times	time	NNS
cord-015021-pol2qm74	5146	35	the	the	DT
cord-015021-pol2qm74	5146	36	volume	volume	NN
cord-015021-pol2qm74	5146	37	of	of	IN
cord-015021-pol2qm74	5146	38	the	the	DT
cord-015021-pol2qm74	5146	39	shed	shed	JJ
cord-015021-pol2qm74	5146	40	blood	blood	NN
cord-015021-pol2qm74	5146	41	.	.	.
cord-015021-pol2qm74	5147	1	Serial	serial	JJ
cord-015021-pol2qm74	5147	2	blood	blood	NN
cord-015021-pol2qm74	5147	3	samples	sample	NNS
cord-015021-pol2qm74	5147	4	for	for	IN
cord-015021-pol2qm74	5147	5	tumor	tumor	NN
cord-015021-pol2qm74	5147	6	necrosis	necrosis	NN
cord-015021-pol2qm74	5147	7	factor	factor	NN
cord-015021-pol2qm74	5147	8	(	(	-LRB-
cord-015021-pol2qm74	5147	9	TNF	TNF	NNP
cord-015021-pol2qm74	5147	10	)	)	-RRB-
cord-015021-pol2qm74	5147	11	determination	determination	NN
cord-015021-pol2qm74	5147	12	(	(	-LRB-
cord-015021-pol2qm74	5147	13	a	a	DT
cord-015021-pol2qm74	5147	14	modified	modify	VBN
cord-015021-pol2qm74	5147	15	flow	flow	NN
cord-015021-pol2qm74	5147	16	-	-	HYPH
cord-015021-pol2qm74	5147	17	cytomeUic	cytomeuic	NN
cord-015021-pol2qm74	5147	18	WEHI	WEHI	NNP
cord-015021-pol2qm74	5147	19	cell	cell	NN
cord-015021-pol2qm74	5147	20	bioassay	bioassay	NN
cord-015021-pol2qm74	5147	21	)	)	-RRB-
cord-015021-pol2qm74	5147	22	were	be	VBD
cord-015021-pol2qm74	5147	23	obtained	obtain	VBN
cord-015021-pol2qm74	5147	24	at	at	IN
cord-015021-pol2qm74	5147	25	baseline	baseline	NN
cord-015021-pol2qm74	5147	26	,	,	,
cord-015021-pol2qm74	5147	27	during	during	IN
cord-015021-pol2qm74	5147	28	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5147	29	and	and	CC
cord-015021-pol2qm74	5147	30	following	follow	VBG
cord-015021-pol2qm74	5147	31	resuscitation	resuscitation	NN
cord-015021-pol2qm74	5147	32	.	.	.
cord-015021-pol2qm74	5148	1	Liver	liver	NN
cord-015021-pol2qm74	5148	2	blood	blood	NN
cord-015021-pol2qm74	5148	3	flow	flow	NN
cord-015021-pol2qm74	5148	4	measurements	measurement	NNS
cord-015021-pol2qm74	5148	5	by	by	IN
cord-015021-pol2qm74	5148	6	low	low	JJ
cord-015021-pol2qm74	5148	7	dose	dose	NN
cord-015021-pol2qm74	5148	8	galactose	galactose	NN
cord-015021-pol2qm74	5148	9	clearance	clearance	NN
cord-015021-pol2qm74	5148	10	(	(	-LRB-
cord-015021-pol2qm74	5148	11	GLC	GLC	NNP
cord-015021-pol2qm74	5148	12	)	)	-RRB-
cord-015021-pol2qm74	5148	13	and	and	CC
cord-015021-pol2qm74	5148	14	functional	functional	JJ
cord-015021-pol2qm74	5148	15	bepatocyte	bepatocyte	CC
cord-015021-pol2qm74	5148	16	mass	mass	NN
cord-015021-pol2qm74	5148	17	(	(	-LRB-
cord-015021-pol2qm74	5148	18	FHM	FHM	NNP
cord-015021-pol2qm74	5148	19	;	;	:
cord-015021-pol2qm74	5149	1	defared	defare	VBN
cord-015021-pol2qm74	5149	2	as	as	IN
cord-015021-pol2qm74	5149	3	galactose	galactose	NN
cord-015021-pol2qm74	5149	4	elimination	elimination	NN
cord-015021-pol2qm74	5149	5	capacity	capacity	NN
cord-015021-pol2qm74	5149	6	[	[	-LRB-
cord-015021-pol2qm74	5149	7	GEC	GEC	NNP
cord-015021-pol2qm74	5149	8	]	]	-RRB-
cord-015021-pol2qm74	5149	9	from	from	IN
cord-015021-pol2qm74	5149	10	the	the	DT
cord-015021-pol2qm74	5149	11	zero	zero	CD
cord-015021-pol2qm74	5149	12	order	order	NN
cord-015021-pol2qm74	5149	13	portion	portion	NN
cord-015021-pol2qm74	5149	14	of	of	IN
cord-015021-pol2qm74	5149	15	the	the	DT
cord-015021-pol2qm74	5149	16	plasma	plasma	NN
cord-015021-pol2qm74	5149	17	disappearance	disappearance	NN
cord-015021-pol2qm74	5149	18	curve	curve	NN
cord-015021-pol2qm74	5149	19	following	follow	VBG
cord-015021-pol2qm74	5149	20	an	an	DT
cord-015021-pol2qm74	5149	21	intravenous	intravenous	JJ
cord-015021-pol2qm74	5149	22	galactose	galactose	NN
cord-015021-pol2qm74	5149	23	bolus	bolus	NN
cord-015021-pol2qm74	5149	24	[	[	-LRB-
cord-015021-pol2qm74	5149	25	500	500	CD
cord-015021-pol2qm74	5149	26	mg	mg	NNP
cord-015021-pol2qm74	5149	27	/	/	SYM
cord-015021-pol2qm74	5149	28	kg	kg	NNP
cord-015021-pol2qm74	5149	29	]	]	-RRB-
cord-015021-pol2qm74	5149	30	,	,	,
cord-015021-pol2qm74	5149	31	divided	divide	VBN
cord-015021-pol2qm74	5149	32	by	by	IN
cord-015021-pol2qm74	5149	33	liver	liver	NN
cord-015021-pol2qm74	5149	34	weight	weight	NN
cord-015021-pol2qm74	5149	35	)	)	-RRB-
cord-015021-pol2qm74	5149	36	were	be	VBD
cord-015021-pol2qm74	5149	37	measured	measure	VBN
cord-015021-pol2qm74	5149	38	before	before	IN
cord-015021-pol2qm74	5149	39	shock	shock	NN
cord-015021-pol2qm74	5149	40	and	and	CC
cord-015021-pol2qm74	5149	41	after	after	IN
cord-015021-pol2qm74	5149	42	resuscitation	resuscitation	NN
cord-015021-pol2qm74	5149	43	.	.	.
cord-015021-pol2qm74	5150	1	RESULTS	result	NNS
cord-015021-pol2qm74	5150	2	:	:	:
cord-015021-pol2qm74	5151	1	Higher	high	JJR
cord-015021-pol2qm74	5151	2	survival	survival	NN
cord-015021-pol2qm74	5151	3	rates	rate	NNS
cord-015021-pol2qm74	5151	4	(	(	-LRB-
cord-015021-pol2qm74	5151	5	p	p	NN
cord-015021-pol2qm74	5151	6	<	<	XX
cord-015021-pol2qm74	5151	7	.05	.05	NFP
cord-015021-pol2qm74	5151	8	)	)	-RRB-
cord-015021-pol2qm74	5151	9	were	be	VBD
cord-015021-pol2qm74	5151	10	observed	observe	VBN
cord-015021-pol2qm74	5151	11	in	in	IN
cord-015021-pol2qm74	5151	12	control	control	NN
cord-015021-pol2qm74	5151	13	as	as	IN
cord-015021-pol2qm74	5151	14	compared	compare	VBN
cord-015021-pol2qm74	5151	15	with	with	IN
cord-015021-pol2qm74	5151	16	cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	5151	17	rats	rat	NNS
cord-015021-pol2qm74	5151	18	.	.	.
cord-015021-pol2qm74	5152	1	Shock	shock	NN
cord-015021-pol2qm74	5152	2	produced	produce	VBD
cord-015021-pol2qm74	5152	3	a	a	DT
cord-015021-pol2qm74	5152	4	significant	significant	JJ
cord-015021-pol2qm74	5152	5	reduction	reduction	NN
cord-015021-pol2qm74	5152	6	in	in	IN
cord-015021-pol2qm74	5152	7	GEC	GEC	NNP
cord-015021-pol2qm74	5152	8	(	(	-LRB-
cord-015021-pol2qm74	5152	9	to	to	IN
cord-015021-pol2qm74	5152	10	<	<	XX
cord-015021-pol2qm74	5152	11	0.01	0.01	CD
cord-015021-pol2qm74	5152	12	)	)	-RRB-
cord-015021-pol2qm74	5152	13	;	;	:
cord-015021-pol2qm74	5152	14	FHM	FHM	NNP
cord-015021-pol2qm74	5152	15	(	(	-LRB-
cord-015021-pol2qm74	5152	16	19	19	CD
cord-015021-pol2qm74	5152	17	<	<	XX
cord-015021-pol2qm74	5152	18	.01	.01	NFP
cord-015021-pol2qm74	5152	19	)	)	-RRB-
cord-015021-pol2qm74	5152	20	;	;	:
cord-015021-pol2qm74	5152	21	and	and	CC
cord-015021-pol2qm74	5152	22	liver	liver	NN
cord-015021-pol2qm74	5152	23	blood	blood	NN
cord-015021-pol2qm74	5152	24	flow	flow	NN
cord-015021-pol2qm74	5152	25	(	(	-LRB-
cord-015021-pol2qm74	5152	26	p	p	NN
cord-015021-pol2qm74	5152	27	<	<	XX
cord-015021-pol2qm74	5152	28	0.01	0.01	CD
cord-015021-pol2qm74	5152	29	)	)	-RRB-
cord-015021-pol2qm74	5152	30	in	in	IN
cord-015021-pol2qm74	5152	31	normal	normal	JJ
cord-015021-pol2qm74	5152	32	and	and	CC
cord-015021-pol2qm74	5152	33	cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	5152	34	rats	rat	NNS
cord-015021-pol2qm74	5152	35	.	.	.
cord-015021-pol2qm74	5153	1	Decreases	decrease	NNS
cord-015021-pol2qm74	5153	2	in	in	IN
cord-015021-pol2qm74	5153	3	GEC	GEC	NNP
cord-015021-pol2qm74	5153	4	and	and	CC
cord-015021-pol2qm74	5153	5	FI	FI	NNP
cord-015021-pol2qm74	5153	6	-	-	HYPH
cord-015021-pol2qm74	5153	7	IM	IM	NNP
cord-015021-pol2qm74	5153	8	were	be	VBD
cord-015021-pol2qm74	5153	9	greater	great	JJR
cord-015021-pol2qm74	5153	10	(	(	-LRB-
cord-015021-pol2qm74	5153	11	p	p	NN
cord-015021-pol2qm74	5153	12	<	<	XX
cord-015021-pol2qm74	5153	13	0.05	0.05	CD
cord-015021-pol2qm74	5153	14	)	)	-RRB-
cord-015021-pol2qm74	5153	15	in	in	IN
cord-015021-pol2qm74	5153	16	cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	5153	17	rots	rot	NNS
cord-015021-pol2qm74	5153	18	.	.	.
cord-015021-pol2qm74	5154	1	TNF	TNF	NNP
cord-015021-pol2qm74	5154	2	levels	level	NNS
cord-015021-pol2qm74	5154	3	were	be	VBD
cord-015021-pol2qm74	5154	4	higher	high	JJR
cord-015021-pol2qm74	5154	5	(	(	-LRB-
cord-015021-pol2qm74	5154	6	p	p	NN
cord-015021-pol2qm74	5154	7	<	<	XX
cord-015021-pol2qm74	5154	8	0.05	0.05	CD
cord-015021-pol2qm74	5154	9	)	)	-RRB-
cord-015021-pol2qm74	5154	10	in	in	IN
cord-015021-pol2qm74	5154	11	cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	5154	12	rats	rat	NNS
cord-015021-pol2qm74	5154	13	at	at	IN
cord-015021-pol2qm74	5154	14	baseline	baseline	NN
cord-015021-pol2qm74	5154	15	and	and	CC
cord-015021-pol2qm74	5154	16	during	during	IN
cord-015021-pol2qm74	5154	17	induction	induction	NN
cord-015021-pol2qm74	5154	18	of	of	IN
cord-015021-pol2qm74	5154	19	shock	shock	NN
cord-015021-pol2qm74	5154	20	.	.	.
cord-015021-pol2qm74	5155	1	Pre	pre	JJ
cord-015021-pol2qm74	5155	2	Gap	Gap	NNP
cord-015021-pol2qm74	5155	3	junctions	junction	NNS
cord-015021-pol2qm74	5155	4	provide	provide	VBP
cord-015021-pol2qm74	5155	5	pathways	pathway	NNS
cord-015021-pol2qm74	5155	6	for	for	IN
cord-015021-pol2qm74	5155	7	metabolic	metabolic	JJ
cord-015021-pol2qm74	5155	8	signals	signal	NNS
cord-015021-pol2qm74	5155	9	between	between	IN
cord-015021-pol2qm74	5155	10	cells	cell	NNS
cord-015021-pol2qm74	5155	11	.	.	.
cord-015021-pol2qm74	5156	1	In	in	IN
cord-015021-pol2qm74	5156	2	the	the	DT
cord-015021-pol2qm74	5156	3	liver	liver	NN
cord-015021-pol2qm74	5156	4	,	,	,
cord-015021-pol2qm74	5156	5	the	the	DT
cord-015021-pol2qm74	5156	6	majority	majority	NN
cord-015021-pol2qm74	5156	7	of	of	IN
cord-015021-pol2qm74	5156	8	gap	gap	NN
cord-015021-pol2qm74	5156	9	junctions	junction	NNS
cord-015021-pol2qm74	5156	10	are	be	VBP
cord-015021-pol2qm74	5156	11	composed	compose	VBN
cord-015021-pol2qm74	5156	12	of	of	IN
cord-015021-pol2qm74	5156	13	connexin	connexin	NNP
cord-015021-pol2qm74	5156	14	32	32	CD
cord-015021-pol2qm74	5156	15	(	(	-LRB-
cord-015021-pol2qm74	5156	16	Cx32	Cx32	NNP
cord-015021-pol2qm74	5156	17	)	)	-RRB-
cord-015021-pol2qm74	5156	18	polypeptide	polypeptide	NN
cord-015021-pol2qm74	5156	19	subunits	subunit	NNS
cord-015021-pol2qm74	5156	20	,	,	,
cord-015021-pol2qm74	5156	21	and	and	CC
cord-015021-pol2qm74	5156	22	are	be	VBP
cord-015021-pol2qm74	5156	23	regulated	regulate	VBN
cord-015021-pol2qm74	5156	24	by	by	IN
cord-015021-pol2qm74	5156	25	gluconeogenic	gluconeogenic	JJ
cord-015021-pol2qm74	5156	26	hormones	hormone	NNS
cord-015021-pol2qm74	5156	27	.	.	.
cord-015021-pol2qm74	5157	1	Since	since	IN
cord-015021-pol2qm74	5157	2	sepsis	sepsis	NN
cord-015021-pol2qm74	5157	3	and	and	CC
cord-015021-pol2qm74	5157	4	other	other	JJ
cord-015021-pol2qm74	5157	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5157	6	states	state	NNS
cord-015021-pol2qm74	5157	7	alter	alter	VBP
cord-015021-pol2qm74	5157	8	hepatic	hepatic	JJ
cord-015021-pol2qm74	5157	9	glucoregulatory	glucoregulatory	NN
cord-015021-pol2qm74	5157	10	control	control	NN
cord-015021-pol2qm74	5157	11	,	,	,
cord-015021-pol2qm74	5157	12	we	-PRON-	PRP
cord-015021-pol2qm74	5157	13	have	have	VBP
cord-015021-pol2qm74	5157	14	evaluated	evaluate	VBN
cord-015021-pol2qm74	5157	15	the	the	DT
cord-015021-pol2qm74	5157	16	contribution	contribution	NN
cord-015021-pol2qm74	5157	17	of	of	IN
cord-015021-pol2qm74	5157	18	gap	gap	NN
cord-015021-pol2qm74	5157	19	junctional	junctional	JJ
cord-015021-pol2qm74	5157	20	conductance	conductance	NN
cord-015021-pol2qm74	5157	21	to	to	IN
cord-015021-pol2qm74	5157	22	the	the	DT
cord-015021-pol2qm74	5157	23	metabolic	metabolic	JJ
cord-015021-pol2qm74	5157	24	dysregulation	dysregulation	NN
cord-015021-pol2qm74	5157	25	in	in	IN
cord-015021-pol2qm74	5157	26	the	the	DT
cord-015021-pol2qm74	5157	27	liver	liver	NN
cord-015021-pol2qm74	5157	28	.	.	.
cord-015021-pol2qm74	5158	1	An	an	DT
cord-015021-pol2qm74	5158	2	acute	acute	JJ
cord-015021-pol2qm74	5158	3	inflammation	inflammation	NN
cord-015021-pol2qm74	5158	4	was	be	VBD
cord-015021-pol2qm74	5158	5	induced	induce	VBN
cord-015021-pol2qm74	5158	6	in	in	IN
cord-015021-pol2qm74	5158	7	rats	rat	NNS
cord-015021-pol2qm74	5158	8	by	by	IN
cord-015021-pol2qm74	5158	9	injection	injection	NN
cord-015021-pol2qm74	5158	10	with	with	IN
cord-015021-pol2qm74	5158	11	E.	E.	NNP
cord-015021-pol2qm74	5158	12	coli	coli	NNS
cord-015021-pol2qm74	5158	13	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5159	1	(	(	-LRB-
cord-015021-pol2qm74	5159	2	LPS	LPS	NNP
cord-015021-pol2qm74	5159	3	lmg	lmg	NNP
cord-015021-pol2qm74	5159	4	/	/	SYM
cord-015021-pol2qm74	5159	5	kg	kg	NNP
cord-015021-pol2qm74	5159	6	)	)	-RRB-
cord-015021-pol2qm74	5159	7	.	.	.
cord-015021-pol2qm74	5160	1	Northern	northern	JJ
cord-015021-pol2qm74	5160	2	blot	blot	NN
cord-015021-pol2qm74	5160	3	/	/	SYM
cord-015021-pol2qm74	5160	4	hybridization	hybridization	NN
cord-015021-pol2qm74	5160	5	analysis	analysis	NN
cord-015021-pol2qm74	5160	6	of	of	IN
cord-015021-pol2qm74	5160	7	total	total	JJ
cord-015021-pol2qm74	5160	8	RNA	RNA	NNP
cord-015021-pol2qm74	5160	9	isolated	isolate	VBN
cord-015021-pol2qm74	5160	10	from	from	IN
cord-015021-pol2qm74	5160	11	livers	liver	NNS
cord-015021-pol2qm74	5160	12	after	after	IN
cord-015021-pol2qm74	5160	13	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5160	14	injection	injection	NN
cord-015021-pol2qm74	5160	15	show	show	VBP
cord-015021-pol2qm74	5160	16	a	a	DT
cord-015021-pol2qm74	5160	17	decrease	decrease	NN
cord-015021-pol2qm74	5160	18	in	in	IN
cord-015021-pol2qm74	5160	19	the	the	DT
cord-015021-pol2qm74	5160	20	steady	steady	JJ
cord-015021-pol2qm74	5160	21	state	state	NN
cord-015021-pol2qm74	5160	22	transcript	transcript	NN
cord-015021-pol2qm74	5160	23	levels	level	NNS
cord-015021-pol2qm74	5160	24	of	of	IN
cord-015021-pol2qm74	5160	25	Cx32	Cx32	NNPS
cord-015021-pol2qm74	5160	26	to	to	IN
cord-015021-pol2qm74	5160	27	18	18	CD
cord-015021-pol2qm74	5160	28	%	%	NN
cord-015021-pol2qm74	5160	29	of	of	IN
cord-015021-pol2qm74	5160	30	sham	sham	JJ
cord-015021-pol2qm74	5160	31	controls	control	NNS
cord-015021-pol2qm74	5160	32	.	.	.
cord-015021-pol2qm74	5161	1	Immunostaining	immunostaine	VBG
cord-015021-pol2qm74	5161	2	of	of	IN
cord-015021-pol2qm74	5161	3	liver	liver	NN
cord-015021-pol2qm74	5161	4	sections	section	NNS
cord-015021-pol2qm74	5161	5	using	use	VBG
cord-015021-pol2qm74	5161	6	anti	anti	JJ
cord-015021-pol2qm74	5161	7	-	-	NNP
cord-015021-pol2qm74	5161	8	Cx32	Cx32	NNP
cord-015021-pol2qm74	5161	9	revealed	reveal	VBD
cord-015021-pol2qm74	5161	10	punctate	punctate	NN
cord-015021-pol2qm74	5161	11	fluorescent	fluorescent	NN
cord-015021-pol2qm74	5161	12	staining	stain	VBG
cord-015021-pol2qm74	5161	13	on	on	IN
cord-015021-pol2qm74	5161	14	the	the	DT
cord-015021-pol2qm74	5161	15	plasma	plasma	NN
cord-015021-pol2qm74	5161	16	membrane	membrane	NN
cord-015021-pol2qm74	5161	17	at	at	IN
cord-015021-pol2qm74	5161	18	regions	region	NNS
cord-015021-pol2qm74	5161	19	of	of	IN
cord-015021-pol2qm74	5161	20	call	call	NN
cord-015021-pol2qm74	5161	21	-	-	HYPH
cord-015021-pol2qm74	5161	22	cell	cell	NN
cord-015021-pol2qm74	5161	23	contact	contact	NN
cord-015021-pol2qm74	5161	24	in	in	IN
cord-015021-pol2qm74	5161	25	saline	saline	NN
cord-015021-pol2qm74	5161	26	injected	inject	VBN
cord-015021-pol2qm74	5161	27	animals	animal	NNS
cord-015021-pol2qm74	5161	28	,	,	,
cord-015021-pol2qm74	5161	29	whereas	whereas	RB
cord-015021-pol2qm74	5161	30	,	,	,
cord-015021-pol2qm74	5161	31	staining	staining	NN
cord-015021-pol2qm74	5161	32	was	be	VBD
cord-015021-pol2qm74	5161	33	only	only	RB
cord-015021-pol2qm74	5161	34	observed	observe	VBN
cord-015021-pol2qm74	5161	35	in	in	IN
cord-015021-pol2qm74	5161	36	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	5161	37	vesicles	vesicle	NNS
cord-015021-pol2qm74	5161	38	6	6	CD
cord-015021-pol2qm74	5161	39	hrs	hrs	NN
cord-015021-pol2qm74	5161	40	after	after	IN
cord-015021-pol2qm74	5161	41	animals	animal	NNS
cord-015021-pol2qm74	5161	42	were	be	VBD
cord-015021-pol2qm74	5161	43	treated	treat	VBN
cord-015021-pol2qm74	5161	44	with	with	IN
cord-015021-pol2qm74	5161	45	LPS	LPS	NNP
cord-015021-pol2qm74	5161	46	,	,	,
cord-015021-pol2qm74	5161	47	suggesting	suggest	VBG
cord-015021-pol2qm74	5161	48	the	the	DT
cord-015021-pol2qm74	5161	49	internalization	internalization	NN
cord-015021-pol2qm74	5161	50	of	of	IN
cord-015021-pol2qm74	5161	51	Cx32	Cx32	NNPS
cord-015021-pol2qm74	5161	52	without	without	IN
cord-015021-pol2qm74	5161	53	replacement	replacement	NN
cord-015021-pol2qm74	5161	54	on	on	IN
cord-015021-pol2qm74	5161	55	the	the	DT
cord-015021-pol2qm74	5161	56	cell	cell	NN
cord-015021-pol2qm74	5161	57	surface	surface	NN
cord-015021-pol2qm74	5161	58	.	.	.
cord-015021-pol2qm74	5162	1	The	the	DT
cord-015021-pol2qm74	5162	2	staining	staining	NN
cord-015021-pol2qm74	5162	3	was	be	VBD
cord-015021-pol2qm74	5162	4	quantitated	quantitate	VBN
cord-015021-pol2qm74	5162	5	and	and	CC
cord-015021-pol2qm74	5162	6	expressed	express	VBD
cord-015021-pol2qm74	5162	7	as	as	IN
cord-015021-pol2qm74	5162	8	%	%	NN
cord-015021-pol2qm74	5162	9	of	of	IN
cord-015021-pol2qm74	5162	10	pixels	pixel	NNS
cord-015021-pol2qm74	5162	11	above	above	IN
cord-015021-pol2qm74	5162	12	threshold	threshold	NN
cord-015021-pol2qm74	5162	13	.	.	.
cord-015021-pol2qm74	5163	1	At	at	IN
cord-015021-pol2qm74	5163	2	6hr	6hr	NNP
cord-015021-pol2qm74	5163	3	post	post	NN
cord-015021-pol2qm74	5163	4	injection	injection	NN
cord-015021-pol2qm74	5163	5	3.6	3.6	CD
cord-015021-pol2qm74	5163	6	%	%	NN
cord-015021-pol2qm74	5163	7	ofpixels	ofpixel	NNS
cord-015021-pol2qm74	5163	8	exceeded	exceed	VBD
cord-015021-pol2qm74	5163	9	threshold	threshold	NN
cord-015021-pol2qm74	5163	10	,	,	,
cord-015021-pol2qm74	5163	11	compared	compare	VBN
cord-015021-pol2qm74	5163	12	to	to	IN
cord-015021-pol2qm74	5163	13	16.2	16.2	CD
cord-015021-pol2qm74	5163	14	%	%	NN
cord-015021-pol2qm74	5163	15	in	in	IN
cord-015021-pol2qm74	5163	16	sham	sham	NN
cord-015021-pol2qm74	5163	17	controls	control	NNS
cord-015021-pol2qm74	5163	18	.	.	.
cord-015021-pol2qm74	5164	1	Functional	functional	JJ
cord-015021-pol2qm74	5164	2	gap	gap	NN
cord-015021-pol2qm74	5164	3	junctional	junctional	JJ
cord-015021-pol2qm74	5164	4	communication	communication	NN
cord-015021-pol2qm74	5164	5	was	be	VBD
cord-015021-pol2qm74	5164	6	assessed	assess	VBN
cord-015021-pol2qm74	5164	7	by	by	IN
cord-015021-pol2qm74	5164	8	dye	dye	NN
cord-015021-pol2qm74	5164	9	coupling	coupling	NN
cord-015021-pol2qm74	5164	10	using	use	VBG
cord-015021-pol2qm74	5164	11	lucifer	lucifer	NNP
cord-015021-pol2qm74	5164	12	yellow	yellow	NNP
cord-015021-pol2qm74	5164	13	in	in	IN
cord-015021-pol2qm74	5164	14	an	an	DT
cord-015021-pol2qm74	5164	15	isolated	isolated	JJ
cord-015021-pol2qm74	5164	16	perfused	perfuse	VBN
cord-015021-pol2qm74	5164	17	liver	liver	NN
cord-015021-pol2qm74	5164	18	under	under	IN
cord-015021-pol2qm74	5164	19	intravital	intravital	JJ
cord-015021-pol2qm74	5164	20	fluorescence	fluorescence	NN
cord-015021-pol2qm74	5164	21	microscopy	microscopy	NN
cord-015021-pol2qm74	5164	22	.	.	.
cord-015021-pol2qm74	5165	1	Dye	dye	NN
cord-015021-pol2qm74	5165	2	diffusion	diffusion	NN
cord-015021-pol2qm74	5165	3	was	be	VBD
cord-015021-pol2qm74	5165	4	markedly	markedly	RB
cord-015021-pol2qm74	5165	5	decreased	decrease	VBN
cord-015021-pol2qm74	5165	6	6hr	6hr	NN
cord-015021-pol2qm74	5165	7	after	after	IN
cord-015021-pol2qm74	5165	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5165	9	injection	injection	NN
cord-015021-pol2qm74	5165	10	.	.	.
cord-015021-pol2qm74	5166	1	This	this	DT
cord-015021-pol2qm74	5166	2	suggests	suggest	VBZ
cord-015021-pol2qm74	5166	3	that	that	IN
cord-015021-pol2qm74	5166	4	decreased	decrease	VBD
cord-015021-pol2qm74	5166	5	metabolic	metabolic	JJ
cord-015021-pol2qm74	5166	6	coupling	coupling	NN
cord-015021-pol2qm74	5166	7	after	after	IN
cord-015021-pol2qm74	5166	8	LPS	LPS	NNP
cord-015021-pol2qm74	5166	9	injection	injection	NN
cord-015021-pol2qm74	5166	10	results	result	NNS
cord-015021-pol2qm74	5166	11	from	from	IN
cord-015021-pol2qm74	5166	12	decreased	decrease	VBD
cord-015021-pol2qm74	5166	13	gap	gap	NN
cord-015021-pol2qm74	5166	14	junction	junction	NN
cord-015021-pol2qm74	5166	15	abundance	abundance	NN
cord-015021-pol2qm74	5166	16	.	.	.
cord-015021-pol2qm74	5167	1	The	the	DT
cord-015021-pol2qm74	5167	2	present	present	JJ
cord-015021-pol2qm74	5167	3	data	datum	NNS
cord-015021-pol2qm74	5167	4	suggest	suggest	VBP
cord-015021-pol2qm74	5167	5	that	that	IN
cord-015021-pol2qm74	5167	6	metabolic	metabolic	JJ
cord-015021-pol2qm74	5167	7	dysregulation	dysregulation	NN
cord-015021-pol2qm74	5167	8	during	during	IN
cord-015021-pol2qm74	5167	9	sepsis	sepsis	NN
cord-015021-pol2qm74	5167	10	may	may	MD
cord-015021-pol2qm74	5167	11	arise	arise	VB
cord-015021-pol2qm74	5167	12	in	in	IN
cord-015021-pol2qm74	5167	13	part	part	NN
cord-015021-pol2qm74	5167	14	from	from	IN
cord-015021-pol2qm74	5167	15	changes	change	NNS
cord-015021-pol2qm74	5167	16	in	in	IN
cord-015021-pol2qm74	5167	17	intercellular	intercellular	JJ
cord-015021-pol2qm74	5167	18	communication	communication	NN
cord-015021-pol2qm74	5167	19	caused	cause	VBN
cord-015021-pol2qm74	5167	20	by	by	IN
cord-015021-pol2qm74	5167	21	a	a	DT
cord-015021-pol2qm74	5167	22	decrease	decrease	NN
cord-015021-pol2qm74	5167	23	in	in	IN
cord-015021-pol2qm74	5167	24	gap	gap	NN
cord-015021-pol2qm74	5167	25	junctional	junctional	JJ
cord-015021-pol2qm74	5167	26	expression	expression	NN
cord-015021-pol2qm74	5167	27	and	and	CC
cord-015021-pol2qm74	5167	28	communication	communication	NN
cord-015021-pol2qm74	5167	29	.	.	.
cord-015021-pol2qm74	5168	1	Given	give	VBN
cord-015021-pol2qm74	5168	2	the	the	DT
cord-015021-pol2qm74	5168	3	marked	marked	JJ
cord-015021-pol2qm74	5168	4	metabolic	metabolic	JJ
cord-015021-pol2qm74	5168	5	heterogeneity	heterogeneity	NN
cord-015021-pol2qm74	5168	6	of	of	IN
cord-015021-pol2qm74	5168	7	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5168	8	with	with	IN
cord-015021-pol2qm74	5168	9	respect	respect	NN
cord-015021-pol2qm74	5168	10	to	to	IN
cord-015021-pol2qm74	5168	11	acinar	acinar	JJ
cord-015021-pol2qm74	5168	12	location	location	NN
cord-015021-pol2qm74	5168	13	,	,	,
cord-015021-pol2qm74	5168	14	metabolic	metabolic	JJ
cord-015021-pol2qm74	5168	15	signaling	signaling	NN
cord-015021-pol2qm74	5168	16	via	via	IN
cord-015021-pol2qm74	5168	17	gap	gap	NN
cord-015021-pol2qm74	5168	18	junctions	junction	NNS
cord-015021-pol2qm74	5168	19	most	most	RBS
cord-015021-pol2qm74	5168	20	likely	likely	RB
cord-015021-pol2qm74	5168	21	serves	serve	VBZ
cord-015021-pol2qm74	5168	22	to	to	TO
cord-015021-pol2qm74	5168	23	moderate	moderate	VB
cord-015021-pol2qm74	5168	24	this	this	DT
cord-015021-pol2qm74	5168	25	heterogeneity	heterogeneity	NN
cord-015021-pol2qm74	5168	26	,	,	,
cord-015021-pol2qm74	5168	27	contributing	contribute	VBG
cord-015021-pol2qm74	5168	28	to	to	IN
cord-015021-pol2qm74	5168	29	a	a	DT
cord-015021-pol2qm74	5168	30	coordinated	coordinated	JJ
cord-015021-pol2qm74	5168	31	metabolic	metabolic	JJ
cord-015021-pol2qm74	5168	32	response	response	NN
cord-015021-pol2qm74	5168	33	.	.	.
cord-015021-pol2qm74	5169	1	Altered	alter	VBN
cord-015021-pol2qm74	5169	2	cellular	cellular	JJ
cord-015021-pol2qm74	5169	3	Ca	Ca	NNP
cord-015021-pol2qm74	5169	4	2÷	2÷	CD
cord-015021-pol2qm74	5169	5	regulation	regulation	NN
cord-015021-pol2qm74	5169	6	might	may	MD
cord-015021-pol2qm74	5169	7	be	be	VB
cord-015021-pol2qm74	5169	8	a	a	DT
cord-015021-pol2qm74	5169	9	critical	critical	JJ
cord-015021-pol2qm74	5169	10	step	step	NN
cord-015021-pol2qm74	5169	11	in	in	IN
cord-015021-pol2qm74	5169	12	organ	organ	NN
cord-015021-pol2qm74	5169	13	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5169	14	during	during	IN
cord-015021-pol2qm74	5169	15	sepsis	sepsis	NN
cord-015021-pol2qm74	5169	16	and	and	CC
cord-015021-pol2qm74	5169	17	ischemia	ischemia	NN
cord-015021-pol2qm74	5169	18	/	/	SYM
cord-015021-pol2qm74	5169	19	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5169	20	events	event	NNS
cord-015021-pol2qm74	5169	21	.	.	.
cord-015021-pol2qm74	5170	1	The	the	DT
cord-015021-pol2qm74	5170	2	aim	aim	NN
cord-015021-pol2qm74	5170	3	of	of	IN
cord-015021-pol2qm74	5170	4	the	the	DT
cord-015021-pol2qm74	5170	5	present	present	JJ
cord-015021-pol2qm74	5170	6	study	study	NN
cord-015021-pol2qm74	5170	7	was	be	VBD
cord-015021-pol2qm74	5170	8	to	to	TO
cord-015021-pol2qm74	5170	9	evaluate	evaluate	VB
cord-015021-pol2qm74	5170	10	hepato	hepato	NNP
cord-015021-pol2qm74	5170	11	-	-	HYPH
cord-015021-pol2qm74	5170	12	ceUular	ceUular	NNP
cord-015021-pol2qm74	5171	1	Ca	ca	RB
cord-015021-pol2qm74	5171	2	2÷	2÷	CD
cord-015021-pol2qm74	5171	3	regulation	regulation	NN
cord-015021-pol2qm74	5171	4	in	in	IN
cord-015021-pol2qm74	5171	5	isehemiah'eperfusion	isehemiah'eperfusion	NNP
cord-015021-pol2qm74	5171	6	after	after	IN
cord-015021-pol2qm74	5171	7	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5171	8	and	and	CC
cord-015021-pol2qm74	5171	9	to	to	TO
cord-015021-pol2qm74	5171	10	assess	assess	VB
cord-015021-pol2qm74	5171	11	effectiveness	effectiveness	NN
cord-015021-pol2qm74	5171	12	of	of	IN
cord-015021-pol2qm74	5171	13	TNFc~-monoclonal	TNFc~-monoclonal	NNP
cord-015021-pol2qm74	5171	14	antibody	antibody	NN
cord-015021-pol2qm74	5171	15	(	(	-LRB-
cord-015021-pol2qm74	5171	16	TNFo~-MoAB	TNFo~-MoAB	NNP
cord-015021-pol2qm74	5171	17	)	)	-RRB-
cord-015021-pol2qm74	5171	18	.	.	.
cord-015021-pol2qm74	5172	1	Methods	method	NNS
cord-015021-pol2qm74	5172	2	.	.	.
cord-015021-pol2qm74	5173	1	Male	Male	NNP
cord-015021-pol2qm74	5173	2	Sprague	Sprague	NNP
cord-015021-pol2qm74	5173	3	-	-	HYPH
cord-015021-pol2qm74	5173	4	Dawley	Dawley	NNP
cord-015021-pol2qm74	5173	5	rats	rat	NNS
cord-015021-pol2qm74	5173	6	(	(	-LRB-
cord-015021-pol2qm74	5173	7	250	250	CD
cord-015021-pol2qm74	5173	8	g	g	NN
cord-015021-pol2qm74	5173	9	,	,	,
cord-015021-pol2qm74	5173	10	n>_6	n>_6	NNP
cord-015021-pol2qm74	5173	11	/	/	SYM
cord-015021-pol2qm74	5173	12	group	group	NN
cord-015021-pol2qm74	5173	13	;	;	:
cord-015021-pol2qm74	5173	14	pentobarbital	pentobarbital	NNP
cord-015021-pol2qm74	5173	15	50	50	CD
cord-015021-pol2qm74	5173	16	mg	mg	NNP
cord-015021-pol2qm74	5173	17	/	/	SYM
cord-015021-pol2qm74	5173	18	kg	kg	NNP
cord-015021-pol2qm74	5173	19	)	)	-RRB-
cord-015021-pol2qm74	5173	20	with	with	IN
cord-015021-pol2qm74	5173	21	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5173	22	for	for	IN
cord-015021-pol2qm74	5173	23	60	60	CD
cord-015021-pol2qm74	5173	24	rain	rain	NN
cord-015021-pol2qm74	5173	25	at	at	IN
cord-015021-pol2qm74	5173	26	40	40	CD
cord-015021-pol2qm74	5173	27	mm	mm	NN
cord-015021-pol2qm74	5173	28	Hg	hg	NN
cord-015021-pol2qm74	5173	29	.	.	.
cord-015021-pol2qm74	5174	1	Reperfusion	reperfusion	NN
cord-015021-pol2qm74	5174	2	by	by	IN
cord-015021-pol2qm74	5174	3	Ringer	Ringer	NNP
cord-015021-pol2qm74	5174	4	's	's	POS
cord-015021-pol2qm74	5174	5	lactate	lactate	NN
cord-015021-pol2qm74	5174	6	(	(	-LRB-
cord-015021-pol2qm74	5174	7	2	2	CD
cord-015021-pol2qm74	5174	8	x	x	SYM
cord-015021-pol2qm74	5174	9	maximal	maximal	JJ
cord-015021-pol2qm74	5174	10	bleed	bleed	NN
cord-015021-pol2qm74	5174	11	out/60	out/60	NNP
cord-015021-pol2qm74	5174	12	min	min	NN
cord-015021-pol2qm74	5174	13	)	)	-RRB-
cord-015021-pol2qm74	5174	14	and	and	CC
cord-015021-pol2qm74	5174	15	60	60	CD
cord-015021-pol2qm74	5174	16	%	%	NN
cord-015021-pol2qm74	5174	17	of	of	IN
cord-015021-pol2qm74	5174	18	citrated	citrated	JJ
cord-015021-pol2qm74	5174	19	shed	shed	JJ
cord-015021-pol2qm74	5174	20	blood	blood	NN
cord-015021-pol2qm74	5174	21	.	.	.
cord-015021-pol2qm74	5175	1	TNFcz	TNFcz	NNP
cord-015021-pol2qm74	5175	2	-	-	HYPH
cord-015021-pol2qm74	5175	3	MoAB	MoAB	NNP
cord-015021-pol2qm74	5176	1	(	(	-LRB-
cord-015021-pol2qm74	5176	2	TN3	TN3	NNP
cord-015021-pol2qm74	5176	3	,	,	,
cord-015021-pol2qm74	5176	4	CeUtech	CeUtech	NNP
cord-015021-pol2qm74	5176	5	,	,	,
cord-015021-pol2qm74	5176	6	20	20	CD
cord-015021-pol2qm74	5176	7	mg	mg	NNP
cord-015021-pol2qm74	5176	8	/	/	SYM
cord-015021-pol2qm74	5176	9	kg	kg	NNS
cord-015021-pol2qm74	5176	10	in	in	IN
cord-015021-pol2qm74	5176	11	0.9	0.9	CD
cord-015021-pol2qm74	5176	12	%	%	NN
cord-015021-pol2qm74	5176	13	NaC1	nac1	NN
cord-015021-pol2qm74	5176	14	)	)	-RRB-
cord-015021-pol2qm74	5176	15	infused	infuse	VBN
cord-015021-pol2qm74	5176	16	during	during	IN
cord-015021-pol2qm74	5176	17	fLrst	fLrst	NNP
cord-015021-pol2qm74	5176	18	5	5	CD
cord-015021-pol2qm74	5176	19	min	min	NN
cord-015021-pol2qm74	5176	20	of	of	IN
cord-015021-pol2qm74	5176	21	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5176	22	.	.	.
cord-015021-pol2qm74	5177	1	At	at	IN
cord-015021-pol2qm74	5177	2	baseline	baseline	NN
cord-015021-pol2qm74	5177	3	,	,	,
cord-015021-pol2qm74	5177	4	end	end	NN
cord-015021-pol2qm74	5177	5	of	of	IN
cord-015021-pol2qm74	5177	6	ischemia	ischemia	NN
cord-015021-pol2qm74	5177	7	and	and	CC
cord-015021-pol2qm74	5177	8	60	60	CD
cord-015021-pol2qm74	5177	9	min	min	NN
cord-015021-pol2qm74	5177	10	of	of	IN
cord-015021-pol2qm74	5177	11	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5177	12	,	,	,
cord-015021-pol2qm74	5177	13	hepatecyte	hepatecyte	NNP
cord-015021-pol2qm74	5177	14	isolation	isolation	NN
cord-015021-pol2qm74	5177	15	by	by	IN
cord-015021-pol2qm74	5177	16	liver	liver	NN
cord-015021-pol2qm74	5177	17	collagenase	collagenase	NNP
cord-015021-pol2qm74	5177	18	perfusion	perfusion	NN
cord-015021-pol2qm74	5177	19	.	.	.
cord-015021-pol2qm74	5177	20	"	"	''
cord-015021-pol2qm74	5177	21	45	45	CD
cord-015021-pol2qm74	5177	22	Hepatocyte	Hepatocyte	NNP
cord-015021-pol2qm74	5177	23	incubation	incubation	NN
cord-015021-pol2qm74	5177	24	(	(	-LRB-
cord-015021-pol2qm74	5177	25	30	30	CD
cord-015021-pol2qm74	5177	26	mg	mg	NNP
cord-015021-pol2qm74	5177	27	w.w./ml	w.w./ml	NNP
cord-015021-pol2qm74	5177	28	)	)	-RRB-
cord-015021-pol2qm74	5177	29	with	with	IN
cord-015021-pol2qm74	5177	30	CaCI	CaCI	NNP
cord-015021-pol2qm74	5177	31	2	2	CD
cord-015021-pol2qm74	5177	32	(	(	-LRB-
cord-015021-pol2qm74	5177	33	0.05	0.05	CD
cord-015021-pol2qm74	5177	34	2	2	CD
cord-015021-pol2qm74	5177	35	+	+	CD
cord-015021-pol2qm74	5178	1	2	2	LS
cord-015021-pol2qm74	5178	2	+	+	SYM
cord-015021-pol2qm74	5178	3	2	2	CD
cord-015021-pol2qm74	5178	4	+	+	CD
cord-015021-pol2qm74	5178	5	MBq	MBq	NNS
cord-015021-pol2qm74	5178	6	/	/	SYM
cord-015021-pol2qm74	5178	7	ml	ml	NN
cord-015021-pol2qm74	5178	8	)	)	-RRB-
cord-015021-pol2qm74	5178	9	for	for	IN
cord-015021-pol2qm74	5178	10	60	60	CD
cord-015021-pol2qm74	5178	11	rain	rain	NN
cord-015021-pol2qm74	5178	12	(	(	-LRB-
cord-015021-pol2qm74	5178	13	Ca	Ca	MD
cord-015021-pol2qm74	5178	14	influx	influx	VB
cord-015021-pol2qm74	5178	15	[	[	-LRB-
cord-015021-pol2qm74	5178	16	slope	slope	NN
cord-015021-pol2qm74	5178	17	,	,	,
cord-015021-pol2qm74	5178	18	1	1	CD
cord-015021-pol2qm74	5178	19	/	/	SYM
cord-015021-pol2qm74	5178	20	mini	mini	NN
cord-015021-pol2qm74	5178	21	;	;	:
cord-015021-pol2qm74	5178	22	Ca	Ca	MD
cord-015021-pol2qm74	5178	23	uptake	uptake	NN
cord-015021-pol2qm74	5178	24	[	[	-LRB-
cord-015021-pol2qm74	5178	25	nmol	nmol	NNP
cord-015021-pol2qm74	5178	26	Ca	Ca	NNP
cord-015021-pol2qm74	5178	27	/mg	/mg	CD
cord-015021-pol2qm74	5178	28	protein	protein	NN
cord-015021-pol2qm74	5178	29	]	]	-RRB-
cord-015021-pol2qm74	5178	30	)	)	-RRB-
cord-015021-pol2qm74	5179	1	w/	w/	NNP
cord-015021-pol2qm74	5179	2	and	and	CC
cord-015021-pol2qm74	5179	3	w/o	without	IN
cord-015021-pol2qm74	5179	4	epinephrine	epinephrine	NN
cord-015021-pol2qm74	5179	5	(	(	-LRB-
cord-015021-pol2qm74	5179	6	EPI	EPI	NNP
cord-015021-pol2qm74	5179	7	,	,	,
cord-015021-pol2qm74	5179	8	100	100	CD
cord-015021-pol2qm74	5179	9	nM	nm	NN
cord-015021-pol2qm74	5179	10	)	)	-RRB-
cord-015021-pol2qm74	5179	11	.	.	.
cord-015021-pol2qm74	5180	1	Hepatecyte	Hepatecyte	NNP
cord-015021-pol2qm74	5180	2	resuspension	resuspension	NN
cord-015021-pol2qm74	5180	3	in	in	IN
cord-015021-pol2qm74	5180	4	radioisotope	radioisotope	NN
cord-015021-pol2qm74	5180	5	-	-	HYPH
cord-015021-pol2qm74	5180	6	free	free	JJ
cord-015021-pol2qm74	5180	7	medium	medium	NN
cord-015021-pol2qm74	5180	8	and	and	CC
cord-015021-pol2qm74	5180	9	farther	farther	JJ
cord-015021-pol2qm74	5180	10	incubation	incubation	NN
cord-015021-pol2qm74	5180	11	(	(	-LRB-
cord-015021-pol2qm74	5180	12	exchangeable	exchangeable	JJ
cord-015021-pol2qm74	5181	1	Ca	ca	NN
cord-015021-pol2qm74	5181	2	2	2	CD
cord-015021-pol2qm74	5181	3	+	+	CD
cord-015021-pol2qm74	5181	4	(	(	-LRB-
cord-015021-pol2qm74	5181	5	Ca2+ex	Ca2+ex	NNP
cord-015021-pol2qm74	5181	6	)	)	-RRB-
cord-015021-pol2qm74	5182	1	[	[	-LRB-
cord-015021-pol2qm74	5182	2	nmol	nmol	JJ
cord-015021-pol2qm74	5182	3	Ca2+/mg	Ca2+/mg	NNP
cord-015021-pol2qm74	5182	4	protein	protein	NN
cord-015021-pol2qm74	5182	5	]	]	-RRB-
cord-015021-pol2qm74	5182	6	;	;	.
cord-015021-pol2qm74	5183	1	Ca	ca	NN
cord-015021-pol2qm74	5183	2	2	2	CD
cord-015021-pol2qm74	5183	3	+	+	CD
cord-015021-pol2qm74	5183	4	membrane	membrane	NN
cord-015021-pol2qm74	5183	5	flux	flux	NN
cord-015021-pol2qm74	5183	6	[	[	-LRB-
cord-015021-pol2qm74	5183	7	nmol	nmol	JJ
cord-015021-pol2qm74	5183	8	Ca2+/mg	Ca2+/mg	NNP
cord-015021-pol2qm74	5183	9	protein'min	protein'min	CD
cord-015021-pol2qm74	5183	10	]	]	-RRB-
cord-015021-pol2qm74	5183	11	)	)	-RRB-
cord-015021-pol2qm74	5183	12	.	.	.
cord-015021-pol2qm74	5184	1	During	during	IN
cord-015021-pol2qm74	5184	2	incubation	incubation	NN
cord-015021-pol2qm74	5184	3	,	,	,
cord-015021-pol2qm74	5184	4	aliquots	aliquot	NNS
cord-015021-pol2qm74	5184	5	(	(	-LRB-
cord-015021-pol2qm74	5184	6	100	100	CD
cord-015021-pol2qm74	5184	7	~tl	~tl	JJ
cord-015021-pol2qm74	5184	8	)	)	-RRB-
cord-015021-pol2qm74	5184	9	were	be	VBD
cord-015021-pol2qm74	5184	10	centrifuged	centrifuge	VBN
cord-015021-pol2qm74	5184	11	through	through	IN
cord-015021-pol2qm74	5184	12	oil	oil	NN
cord-015021-pol2qm74	5184	13	/	/	SYM
cord-015021-pol2qm74	5184	14	lanthanum	lanthanum	NN
cord-015021-pol2qm74	5184	15	gradient	gradient	NN
cord-015021-pol2qm74	5184	16	and	and	CC
cord-015021-pol2qm74	5184	17	acivity	acivity	NN
cord-015021-pol2qm74	5184	18	measured	measure	VBN
cord-015021-pol2qm74	5184	19	by	by	IN
cord-015021-pol2qm74	5184	20	scintillation	scintillation	NN
cord-015021-pol2qm74	5184	21	counting	counting	NN
cord-015021-pol2qm74	5184	22	.	.	.
cord-015021-pol2qm74	5185	1	Statistics	statistic	NNS
cord-015021-pol2qm74	5185	2	:	:	:
cord-015021-pol2qm74	5185	3	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	5185	4	.	.	.
cord-015021-pol2qm74	5186	1	Mean	mean	JJ
cord-015021-pol2qm74	5186	2	+	+	CC
cord-015021-pol2qm74	5186	3	SEM	sem	NN
cord-015021-pol2qm74	5186	4	.	.	.
cord-015021-pol2qm74	5187	1	Results	result	NNS
cord-015021-pol2qm74	5187	2	.	.	.
cord-015021-pol2qm74	5188	1	Hepatocyte	Hepatocyte	NNP
cord-015021-pol2qm74	5188	2	Ca2+ex	Ca2+ex	NNP
cord-015021-pol2qm74	5188	3	and	and	CC
cord-015021-pol2qm74	5188	4	membrane	membrane	NN
cord-015021-pol2qm74	5189	1	Ca	ca	NN
cord-015021-pol2qm74	5189	2	2	2	CD
cord-015021-pol2qm74	5189	3	+	+	CD
cord-015021-pol2qm74	5190	1	flux	flux	NN
cord-015021-pol2qm74	5190	2	were	be	VBD
cord-015021-pol2qm74	5190	3	significantly	significantly	RB
cord-015021-pol2qm74	5190	4	increased	increase	VBN
cord-015021-pol2qm74	5190	5	at	at	IN
cord-015021-pol2qm74	5190	6	both	both	DT
cord-015021-pol2qm74	5190	7	,	,	,
cord-015021-pol2qm74	5190	8	the	the	DT
cord-015021-pol2qm74	5190	9	end	end	NN
cord-015021-pol2qm74	5190	10	of	of	IN
cord-015021-pol2qm74	5190	11	ischemia	ischemia	NN
cord-015021-pol2qm74	5190	12	(	(	-LRB-
cord-015021-pol2qm74	5190	13	14.3+.9	14.3+.9	CD
cord-015021-pol2qm74	5190	14	;	;	:
cord-015021-pol2qm74	5190	15	0.41+.05	0.41+.05	LS
cord-015021-pol2qm74	5190	16	)	)	-RRB-
cord-015021-pol2qm74	5190	17	and	and	CC
cord-015021-pol2qm74	5190	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5190	19	(	(	-LRB-
cord-015021-pol2qm74	5190	20	16.4+.9	16.4+.9	CD
cord-015021-pol2qm74	5190	21	;	;	:
cord-015021-pol2qm74	5190	22	0.50+.2	0.50+.2	CD
cord-015021-pol2qm74	5190	23	)	)	-RRB-
cord-015021-pol2qm74	5190	24	,	,	,
cord-015021-pol2qm74	5190	25	as	as	IN
cord-015021-pol2qm74	5190	26	compared	compare	VBN
cord-015021-pol2qm74	5190	27	to	to	IN
cord-015021-pol2qm74	5190	28	sham	sham	NN
cord-015021-pol2qm74	5190	29	-	-	HYPH
cord-015021-pol2qm74	5190	30	operated	operate	VBN
cord-015021-pol2qm74	5190	31	animals	animal	NNS
cord-015021-pol2qm74	5190	32	(	(	-LRB-
cord-015021-pol2qm74	5190	33	7.6+_.5	7.6+_.5	NNP
cord-015021-pol2qm74	5190	34	;	;	:
cord-015021-pol2qm74	5190	35	0.09+.02)(19<.05	0.09+.02)(19<.05	CD
cord-015021-pol2qm74	5190	36	)	)	-RRB-
cord-015021-pol2qm74	5190	37	.	.	.
cord-015021-pol2qm74	5191	1	TNFc~-MoAB	TNFc~-MoAB	NNP
cord-015021-pol2qm74	5192	1	treatment	treatment	NN
cord-015021-pol2qm74	5192	2	significantly	significantly	RB
cord-015021-pol2qm74	5192	3	prevented	prevent	VBD
cord-015021-pol2qm74	5192	4	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5192	5	-	-	HYPH
cord-015021-pol2qm74	5192	6	induced	induce	VBN
cord-015021-pol2qm74	5192	7	increase	increase	NN
cord-015021-pol2qm74	5192	8	of	of	IN
cord-015021-pol2qm74	5192	9	Ca2+ex	Ca2+ex	NNP
cord-015021-pol2qm74	5192	10	(	(	-LRB-
cord-015021-pol2qm74	5192	11	10+.8	10+.8	CD
cord-015021-pol2qm74	5192	12	)	)	-RRB-
cord-015021-pol2qm74	5192	13	and	and	CC
cord-015021-pol2qm74	5192	14	membrane	membrane	NN
cord-015021-pol2qm74	5193	1	Ca	ca	NN
cord-015021-pol2qm74	5193	2	2	2	CD
cord-015021-pol2qm74	5193	3	+	+	CC
cord-015021-pol2qm74	5193	4	flux	flux	NN
cord-015021-pol2qm74	5193	5	(	(	-LRB-
cord-015021-pol2qm74	5193	6	0.17+.03)(p<.01	0.17+.03)(p<.01	CD
cord-015021-pol2qm74	5193	7	)	)	-RRB-
cord-015021-pol2qm74	5193	8	.	.	.
cord-015021-pol2qm74	5194	1	Fast	Fast	NNP
cord-015021-pol2qm74	5194	2	Ca	Ca	NNP
cord-015021-pol2qm74	5194	3	2	2	CD
cord-015021-pol2qm74	5194	4	+	+	CC
cord-015021-pol2qm74	5194	5	influx	influx	NN
cord-015021-pol2qm74	5194	6	was	be	VBD
cord-015021-pol2qm74	5194	7	significantly	significantly	RB
cord-015021-pol2qm74	5194	8	increased	increase	VBN
cord-015021-pol2qm74	5194	9	by	by	IN
cord-015021-pol2qm74	5194	10	epinephrine	epinephrine	NN
cord-015021-pol2qm74	5194	11	in	in	IN
cord-015021-pol2qm74	5194	12	hepatecytes	hepatecyte	NNS
cord-015021-pol2qm74	5194	13	from	from	IN
cord-015021-pol2qm74	5194	14	sham	sham	NN
cord-015021-pol2qm74	5194	15	-	-	HYPH
cord-015021-pol2qm74	5194	16	operated	operate	VBN
cord-015021-pol2qm74	5194	17	rats	rat	NNS
cord-015021-pol2qm74	5194	18	(	(	-LRB-
cord-015021-pol2qm74	5194	19	0.23+.03	0.23+.03	CD
cord-015021-pol2qm74	5194	20	vs.	vs.	IN
cord-015021-pol2qm74	5194	21	EPI	EPI	NNP
cord-015021-pol2qm74	5194	22	:	:	:
cord-015021-pol2qm74	5194	23	0.52+.1	0.52+.1	CD
cord-015021-pol2qm74	5194	24	,	,	,
cord-015021-pol2qm74	5194	25	p	p	NN
cord-015021-pol2qm74	5194	26	<	<	XX
cord-015021-pol2qm74	5194	27	.05	.05	NFP
cord-015021-pol2qm74	5194	28	)	)	-RRB-
cord-015021-pol2qm74	5194	29	.	.	.
cord-015021-pol2qm74	5195	1	This	this	DT
cord-015021-pol2qm74	5195	2	hormone	hormone	NN
cord-015021-pol2qm74	5195	3	effect	effect	NN
cord-015021-pol2qm74	5195	4	was	be	VBD
cord-015021-pol2qm74	5195	5	not	not	RB
cord-015021-pol2qm74	5195	6	observed	observe	VBN
cord-015021-pol2qm74	5195	7	in	in	IN
cord-015021-pol2qm74	5195	8	isehemia	isehemia	NNP
cord-015021-pol2qm74	5195	9	(	(	-LRB-
cord-015021-pol2qm74	5195	10	0.47+.05	0.47+.05	NNP
cord-015021-pol2qm74	5195	11	,	,	,
cord-015021-pol2qm74	5195	12	EPI	EPI	NNP
cord-015021-pol2qm74	5195	13	:	:	:
cord-015021-pol2qm74	5195	14	0.6!-_.2	0.6!-_.2	LS
cord-015021-pol2qm74	5195	15	)	)	-RRB-
cord-015021-pol2qm74	5195	16	or	or	CC
cord-015021-pol2qm74	5195	17	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5195	18	(	(	-LRB-
cord-015021-pol2qm74	5195	19	untreated	untreated	JJ
cord-015021-pol2qm74	5195	20	:	:	:
cord-015021-pol2qm74	5196	1	0.13+.06	0.13+.06	CD
cord-015021-pol2qm74	5197	1	,	,	,
cord-015021-pol2qm74	5197	2	EPI	EPI	NNP
cord-015021-pol2qm74	5197	3	:	:	:
cord-015021-pol2qm74	5197	4	0.07+.01	0.07+.01	CD
cord-015021-pol2qm74	5197	5	;	;	.
cord-015021-pol2qm74	5198	1	TNFt~-MoAB	TNFt~-MoAB	NNP
cord-015021-pol2qm74	5198	2	:	:	:
cord-015021-pol2qm74	5198	3	0.26_+.04	0.26_+.04	CD
cord-015021-pol2qm74	5198	4	,	,	,
cord-015021-pol2qm74	5198	5	EPI	EPI	NNP
cord-015021-pol2qm74	5198	6	:	:	:
cord-015021-pol2qm74	5198	7	0.33+.07	0.33+.07	LS
cord-015021-pol2qm74	5198	8	)	)	-RRB-
cord-015021-pol2qm74	5198	9	.	.	.
cord-015021-pol2qm74	5199	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	5199	2	.	.	.
cord-015021-pol2qm74	5200	1	The	the	DT
cord-015021-pol2qm74	5200	2	present	present	JJ
cord-015021-pol2qm74	5200	3	study	study	NN
cord-015021-pol2qm74	5200	4	clearly	clearly	RB
cord-015021-pol2qm74	5200	5	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	5200	6	hepato	hepato	JJ
cord-015021-pol2qm74	5200	7	-	-	HYPH
cord-015021-pol2qm74	5200	8	cellular	cellular	JJ
cord-015021-pol2qm74	5201	1	Ca	ca	NN
cord-015021-pol2qm74	5201	2	2	2	CD
cord-015021-pol2qm74	5201	3	+	+	CC
cord-015021-pol2qm74	5201	4	overload	overload	NN
cord-015021-pol2qm74	5201	5	in	in	IN
cord-015021-pol2qm74	5201	6	ischemia	ischemia	NN
cord-015021-pol2qm74	5201	7	and	and	CC
cord-015021-pol2qm74	5201	8	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5201	9	as	as	IN
cord-015021-pol2qm74	5201	10	a	a	DT
cord-015021-pol2qm74	5201	11	result	result	NN
cord-015021-pol2qm74	5201	12	of	of	IN
cord-015021-pol2qm74	5201	13	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5201	14	shock	shock	NN
cord-015021-pol2qm74	5201	15	.	.	.
cord-015021-pol2qm74	5202	1	Analysis	analysis	NN
cord-015021-pol2qm74	5202	2	of	of	IN
cord-015021-pol2qm74	5202	3	membrane	membrane	NN
cord-015021-pol2qm74	5203	1	Ca	ca	NN
cord-015021-pol2qm74	5203	2	2	2	CD
cord-015021-pol2qm74	5203	3	+	+	SYM
cord-015021-pol2qm74	5203	4	fluxes	flux	NNS
cord-015021-pol2qm74	5203	5	and	and	CC
cord-015021-pol2qm74	5203	6	hormone	hormone	NN
cord-015021-pol2qm74	5204	1	Ca	ca	NN
cord-015021-pol2qm74	5204	2	2	2	CD
cord-015021-pol2qm74	5204	3	+	+	CC
cord-015021-pol2qm74	5204	4	mobilization	mobilization	NN
cord-015021-pol2qm74	5204	5	suggests	suggest	VBZ
cord-015021-pol2qm74	5204	6	disturbances	disturbance	NNS
cord-015021-pol2qm74	5204	7	of	of	IN
cord-015021-pol2qm74	5204	8	membrane	membrane	NN
cord-015021-pol2qm74	5205	1	Ca	ca	NN
cord-015021-pol2qm74	5205	2	2	2	CD
cord-015021-pol2qm74	5205	3	+	+	SYM
cord-015021-pol2qm74	5205	4	transport	transport	NN
cord-015021-pol2qm74	5205	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5205	6	,	,	,
cord-015021-pol2qm74	5205	7	e.g.	e.g.	RB
cord-015021-pol2qm74	5205	8	through	through	IN
cord-015021-pol2qm74	5205	9	Ca2	ca2	CD
cord-015021-pol2qm74	5205	10	+	+	CC
cord-015021-pol2qm74	5206	1	-ATPases	-ATPases	NNP
cord-015021-pol2qm74	5206	2	.	.	.
cord-015021-pol2qm74	5207	1	Reperfusion	reperfusion	NN
cord-015021-pol2qm74	5207	2	-	-	HYPH
cord-015021-pol2qm74	5207	3	induced	induce	VBN
cord-015021-pol2qm74	5207	4	oxygen	oxygen	NN
cord-015021-pol2qm74	5207	5	free	free	JJ
cord-015021-pol2qm74	5207	6	radical	radical	JJ
cord-015021-pol2qm74	5207	7	generation	generation	NN
cord-015021-pol2qm74	5207	8	which	which	WDT
cord-015021-pol2qm74	5207	9	affect	affect	VBP
cord-015021-pol2qm74	5207	10	exchange	exchange	NN
cord-015021-pol2qm74	5207	11	kinetics	kinetic	NNS
cord-015021-pol2qm74	5207	12	of	of	IN
cord-015021-pol2qm74	5207	13	cellular	cellular	JJ
cord-015021-pol2qm74	5208	1	Ca	ca	NN
cord-015021-pol2qm74	5208	2	2	2	CD
cord-015021-pol2qm74	5208	3	+	+	SYM
cord-015021-pol2qm74	5208	4	buffering	buffering	NN
cord-015021-pol2qm74	5208	5	compartments	compartment	NNS
cord-015021-pol2qm74	5208	6	might	may	MD
cord-015021-pol2qm74	5208	7	also	also	RB
cord-015021-pol2qm74	5208	8	be	be	VB
cord-015021-pol2qm74	5208	9	operative	operative	JJ
cord-015021-pol2qm74	5208	10	.	.	.
cord-015021-pol2qm74	5209	1	Prevention	prevention	NN
cord-015021-pol2qm74	5209	2	by	by	IN
cord-015021-pol2qm74	5209	3	TNFct	TNFct	NNP
cord-015021-pol2qm74	5209	4	-	-	HYPH
cord-015021-pol2qm74	5209	5	MoAB	MoAB	NNP
cord-015021-pol2qm74	5209	6	indicates	indicate	VBZ
cord-015021-pol2qm74	5209	7	the	the	DT
cord-015021-pol2qm74	5209	8	pivotal	pivotal	JJ
cord-015021-pol2qm74	5209	9	role	role	NN
cord-015021-pol2qm74	5209	10	of	of	IN
cord-015021-pol2qm74	5209	11	TNF	TNF	NNP
cord-015021-pol2qm74	5209	12	as	as	IN
cord-015021-pol2qm74	5209	13	an	an	DT
cord-015021-pol2qm74	5209	14	early	early	JJ
cord-015021-pol2qm74	5209	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5209	16	mediator	mediator	NN
cord-015021-pol2qm74	5209	17	of	of	IN
cord-015021-pol2qm74	5209	18	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5209	19	alterations	alteration	NNS
cord-015021-pol2qm74	5209	20	in	in	IN
cord-015021-pol2qm74	5209	21	signal	signal	JJ
cord-015021-pol2qm74	5209	22	transduetion	transduetion	NN
cord-015021-pol2qm74	5209	23	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5209	24	and	and	CC
cord-015021-pol2qm74	5209	25	cellular	cellular	JJ
cord-015021-pol2qm74	5209	26	homeostasis	homeostasis	NN
cord-015021-pol2qm74	5209	27	.	.	.
cord-015021-pol2qm74	5210	1	Although	although	IN
cord-015021-pol2qm74	5210	2	the	the	DT
cord-015021-pol2qm74	5210	3	precise	precise	JJ
cord-015021-pol2qm74	5210	4	mechanism	mechanism	NN
cord-015021-pol2qm74	5210	5	has	have	VBZ
cord-015021-pol2qm74	5210	6	not	not	RB
cord-015021-pol2qm74	5210	7	yet	yet	RB
cord-015021-pol2qm74	5210	8	been	be	VBN
cord-015021-pol2qm74	5210	9	elucidated	elucidate	VBN
cord-015021-pol2qm74	5210	10	,	,	,
cord-015021-pol2qm74	5210	11	bacterial	bacterial	JJ
cord-015021-pol2qm74	5210	12	translocation	translocation	NN
cord-015021-pol2qm74	5210	13	and	and	CC
cord-015021-pol2qm74	5210	14	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5210	15	absorption	absorption	NN
cord-015021-pol2qm74	5210	16	have	have	VBP
cord-015021-pol2qm74	5210	17	been	be	VBN
cord-015021-pol2qm74	5210	18	frequently	frequently	RB
cord-015021-pol2qm74	5210	19	shown	show	VBN
cord-015021-pol2qm74	5210	20	after	after	IN
cord-015021-pol2qm74	5210	21	burn	burn	NN
cord-015021-pol2qm74	5210	22	,	,	,
cord-015021-pol2qm74	5210	23	and	and	CC
cord-015021-pol2qm74	5210	24	have	have	VBP
cord-015021-pol2qm74	5210	25	been	be	VBN
cord-015021-pol2qm74	5210	26	postulated	postulate	VBN
cord-015021-pol2qm74	5210	27	to	to	TO
cord-015021-pol2qm74	5210	28	be	be	VB
cord-015021-pol2qm74	5210	29	one	one	CD
cord-015021-pol2qm74	5210	30	of	of	IN
cord-015021-pol2qm74	5210	31	the	the	DT
cord-015021-pol2qm74	5210	32	underlying	underlie	VBG
cord-015021-pol2qm74	5210	33	processes	process	NNS
cord-015021-pol2qm74	5210	34	of	of	IN
cord-015021-pol2qm74	5210	35	sepsis	sepsis	NN
cord-015021-pol2qm74	5210	36	.	.	.
cord-015021-pol2qm74	5211	1	The	the	DT
cord-015021-pol2qm74	5211	2	purpose	purpose	NN
cord-015021-pol2qm74	5211	3	of	of	IN
cord-015021-pol2qm74	5211	4	the	the	DT
cord-015021-pol2qm74	5211	5	current	current	JJ
cord-015021-pol2qm74	5211	6	study	study	NN
cord-015021-pol2qm74	5211	7	is	be	VBZ
cord-015021-pol2qm74	5211	8	to	to	TO
cord-015021-pol2qm74	5211	9	define	define	VB
cord-015021-pol2qm74	5211	10	the	the	DT
cord-015021-pol2qm74	5211	11	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	5211	12	response	response	NN
cord-015021-pol2qm74	5211	13	of	of	IN
cord-015021-pol2qm74	5211	14	the	the	DT
cord-015021-pol2qm74	5211	15	liver	liver	NN
cord-015021-pol2qm74	5211	16	to	to	IN
cord-015021-pol2qm74	5211	17	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5211	18	release	release	NN
cord-015021-pol2qm74	5211	19	in	in	IN
cord-015021-pol2qm74	5211	20	burns	burn	NNS
cord-015021-pol2qm74	5211	21	,	,	,
cord-015021-pol2qm74	5211	22	in	in	IN
cord-015021-pol2qm74	5211	23	correlation	correlation	NN
cord-015021-pol2qm74	5211	24	to	to	IN
cord-015021-pol2qm74	5211	25	bacterial	bacterial	JJ
cord-015021-pol2qm74	5211	26	translocation	translocation	NN
cord-015021-pol2qm74	5211	27	.	.	.
cord-015021-pol2qm74	5212	1	Twelve	twelve	CD
cord-015021-pol2qm74	5212	2	female	female	JJ
cord-015021-pol2qm74	5212	3	minipigs	minipig	NNS
cord-015021-pol2qm74	5212	4	,	,	,
cord-015021-pol2qm74	5212	5	weighing	weigh	VBG
cord-015021-pol2qm74	5212	6	20	20	CD
cord-015021-pol2qm74	5212	7	-	-	SYM
cord-015021-pol2qm74	5212	8	28	28	CD
cord-015021-pol2qm74	5212	9	Kg	Kg	NNP
cord-015021-pol2qm74	5212	10	,	,	,
cord-015021-pol2qm74	5212	11	underwent	undergo	VBD
cord-015021-pol2qm74	5212	12	a	a	DT
cord-015021-pol2qm74	5212	13	laparotomy	laparotomy	NN
cord-015021-pol2qm74	5212	14	&	&	CC
cord-015021-pol2qm74	5212	15	transition	transition	NN
cord-015021-pol2qm74	5212	16	time	time	NN
cord-015021-pol2qm74	5212	17	ultrasonic	ultrasonic	JJ
cord-015021-pol2qm74	5212	18	flow	flow	NN
cord-015021-pol2qm74	5212	19	probes	probe	NNS
cord-015021-pol2qm74	5212	20	were	be	VBD
cord-015021-pol2qm74	5212	21	positioned	position	VBN
cord-015021-pol2qm74	5212	22	on	on	IN
cord-015021-pol2qm74	5212	23	the	the	DT
cord-015021-pol2qm74	5212	24	portal	portal	JJ
cord-015021-pol2qm74	5212	25	vein	vein	NN
cord-015021-pol2qm74	5212	26	,	,	,
cord-015021-pol2qm74	5212	27	the	the	DT
cord-015021-pol2qm74	5212	28	common	common	JJ
cord-015021-pol2qm74	5212	29	hepatic	hepatic	JJ
cord-015021-pol2qm74	5212	30	artery	artery	NN
cord-015021-pol2qm74	5212	31	,	,	,
cord-015021-pol2qm74	5212	32	and	and	CC
cord-015021-pol2qm74	5212	33	the	the	DT
cord-015021-pol2qm74	5212	34	superior	superior	JJ
cord-015021-pol2qm74	5212	35	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	5212	36	artery	artery	NN
cord-015021-pol2qm74	5212	37	.	.	.
cord-015021-pol2qm74	5213	1	6.5	6.5	CD
cord-015021-pol2qm74	5213	2	Fr	Fr	NNP
cord-015021-pol2qm74	5213	3	catheters	catheter	NNS
cord-015021-pol2qm74	5213	4	were	be	VBD
cord-015021-pol2qm74	5213	5	inserted	insert	VBN
cord-015021-pol2qm74	5213	6	in	in	IN
cord-015021-pol2qm74	5213	7	the	the	DT
cord-015021-pol2qm74	5213	8	superior	superior	JJ
cord-015021-pol2qm74	5213	9	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	5213	10	vein	vein	NN
cord-015021-pol2qm74	5213	11	and	and	CC
cord-015021-pol2qm74	5213	12	the	the	DT
cord-015021-pol2qm74	5213	13	left	left	JJ
cord-015021-pol2qm74	5213	14	hepatic	hepatic	JJ
cord-015021-pol2qm74	5213	15	vein	vein	NN
cord-015021-pol2qm74	5213	16	.	.	.
cord-015021-pol2qm74	5214	1	A	a	DT
cord-015021-pol2qm74	5214	2	jejunostomy	jejunostomy	NN
cord-015021-pol2qm74	5214	3	was	be	VBD
cord-015021-pol2qm74	5214	4	also	also	RB
cord-015021-pol2qm74	5214	5	performed	perform	VBN
cord-015021-pol2qm74	5214	6	.	.	.
cord-015021-pol2qm74	5215	1	After	after	IN
cord-015021-pol2qm74	5215	2	five	five	CD
cord-015021-pol2qm74	5215	3	days	day	NNS
cord-015021-pol2qm74	5215	4	all	all	DT
cord-015021-pol2qm74	5215	5	animals	animal	NNS
cord-015021-pol2qm74	5215	6	were	be	VBD
cord-015021-pol2qm74	5215	7	anaesthetized	anaesthetize	VBN
cord-015021-pol2qm74	5215	8	and	and	CC
cord-015021-pol2qm74	5215	9	randomized	randomize	VBN
cord-015021-pol2qm74	5215	10	to	to	TO
cord-015021-pol2qm74	5215	11	receive	receive	VB
cord-015021-pol2qm74	5215	12	40	40	CD
cord-015021-pol2qm74	5215	13	%	%	NN
cord-015021-pol2qm74	5215	14	of	of	IN
cord-015021-pol2qm74	5215	15	TBS	tbs	NN
cord-015021-pol2qm74	5216	1	A	a	DT
cord-015021-pol2qm74	5216	2	third	third	JJ
cord-015021-pol2qm74	5216	3	degree	degree	NN
cord-015021-pol2qm74	5216	4	burn	burn	NN
cord-015021-pol2qm74	5216	5	.	.	.
cord-015021-pol2qm74	5217	1	Eighteen	eighteen	CD
cord-015021-pol2qm74	5217	2	hours	hour	NNS
cord-015021-pol2qm74	5217	3	after	after	IN
cord-015021-pol2qm74	5217	4	burn	burn	NN
cord-015021-pol2qm74	5217	5	.	.	.
cord-015021-pol2qm74	5218	1	100	100	CD
cord-015021-pol2qm74	5218	2	gg	gg	NNP
cord-015021-pol2qm74	5218	3	/	/	SYM
cord-015021-pol2qm74	5218	4	Kg	Kg	NNP
cord-015021-pol2qm74	5218	5	E.	E.	NNP
cord-015021-pol2qm74	5218	6	Coli	Coli	NNP
cord-015021-pol2qm74	5218	7	LPS	LPS	NNP
cord-015021-pol2qm74	5218	8	was	be	VBD
cord-015021-pol2qm74	5218	9	intravenously	intravenously	RB
cord-015021-pol2qm74	5218	10	administered	administer	VBN
cord-015021-pol2qm74	5218	11	over	over	IN
cord-015021-pol2qm74	5218	12	30	30	CD
cord-015021-pol2qm74	5218	13	rain	rain	NN
cord-015021-pol2qm74	5218	14	.	.	.
cord-015021-pol2qm74	5219	1	alI	ali	JJ
cord-015021-pol2qm74	5219	2	animals	animal	NNS
cord-015021-pol2qm74	5219	3	were	be	VBD
cord-015021-pol2qm74	5219	4	studied	study	VBN
cord-015021-pol2qm74	5219	5	for	for	IN
cord-015021-pol2qm74	5219	6	additional	additional	JJ
cord-015021-pol2qm74	5219	7	24	24	CD
cord-015021-pol2qm74	5219	8	hours	hour	NNS
cord-015021-pol2qm74	5219	9	and	and	CC
cord-015021-pol2qm74	5219	10	then	then	RB
cord-015021-pol2qm74	5219	11	sacrificed	sacrifice	VBD
cord-015021-pol2qm74	5219	12	.	.	.
cord-015021-pol2qm74	5220	1	Several	several	JJ
cord-015021-pol2qm74	5220	2	recent	recent	JJ
cord-015021-pol2qm74	5220	3	data	datum	NNS
cord-015021-pol2qm74	5220	4	suggest	suggest	VBP
cord-015021-pol2qm74	5220	5	that	that	IN
cord-015021-pol2qm74	5220	6	in	in	IN
cord-015021-pol2qm74	5220	7	severe	severe	JJ
cord-015021-pol2qm74	5220	8	injuries	injury	NNS
cord-015021-pol2qm74	5220	9	,	,	,
cord-015021-pol2qm74	5220	10	such	such	JJ
cord-015021-pol2qm74	5220	11	as	as	IN
cord-015021-pol2qm74	5220	12	shock	shock	NN
cord-015021-pol2qm74	5220	13	state	state	NN
cord-015021-pol2qm74	5220	14	,	,	,
cord-015021-pol2qm74	5220	15	the	the	DT
cord-015021-pol2qm74	5220	16	gradual	gradual	JJ
cord-015021-pol2qm74	5220	17	activation	activation	NN
cord-015021-pol2qm74	5220	18	of	of	IN
cord-015021-pol2qm74	5220	19	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5220	20	cells	cell	NNS
cord-015021-pol2qm74	5220	21	and	and	CC
cord-015021-pol2qm74	5220	22	the	the	DT
cord-015021-pol2qm74	5220	23	excessive	excessive	JJ
cord-015021-pol2qm74	5220	24	release	release	NN
cord-015021-pol2qm74	5220	25	of	of	IN
cord-015021-pol2qm74	5220	26	destructive	destructive	JJ
cord-015021-pol2qm74	5220	27	and	and	CC
cord-015021-pol2qm74	5220	28	immunosuppresive	immunosuppresive	JJ
cord-015021-pol2qm74	5220	29	products	product	NNS
cord-015021-pol2qm74	5220	30	from	from	IN
cord-015021-pol2qm74	5220	31	macrophages	macrophage	NNS
cord-015021-pol2qm74	5220	32	may	may	MD
cord-015021-pol2qm74	5220	33	contribute	contribute	VB
cord-015021-pol2qm74	5220	34	to	to	IN
cord-015021-pol2qm74	5220	35	the	the	DT
cord-015021-pol2qm74	5220	36	development	development	NN
cord-015021-pol2qm74	5220	37	of	of	IN
cord-015021-pol2qm74	5220	38	"	"	``
cord-015021-pol2qm74	5220	39	multiple	multiple	JJ
cord-015021-pol2qm74	5220	40	organ	organ	NN
cord-015021-pol2qm74	5220	41	failure	failure	NN
cord-015021-pol2qm74	5220	42	"	"	''
cord-015021-pol2qm74	5220	43	.	.	.
cord-015021-pol2qm74	5221	1	In	in	IN
cord-015021-pol2qm74	5221	2	in	in	IN
cord-015021-pol2qm74	5221	3	vivo	vivo	NN
cord-015021-pol2qm74	5221	4	experiments	experiment	NNS
cord-015021-pol2qm74	5221	5	in	in	IN
cord-015021-pol2qm74	5221	6	mice	mouse	NNS
cord-015021-pol2qm74	5221	7	,	,	,
cord-015021-pol2qm74	5221	8	the	the	DT
cord-015021-pol2qm74	5221	9	effect	effect	NN
cord-015021-pol2qm74	5221	10	of	of	IN
cord-015021-pol2qm74	5221	11	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5221	12	cell	cell	NN
cord-015021-pol2qm74	5221	13	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	5221	14	blockade	blockade	NN
cord-015021-pol2qm74	5221	15	on	on	IN
cord-015021-pol2qm74	5221	16	the	the	DT
cord-015021-pol2qm74	5221	17	correlation	correlation	NN
cord-015021-pol2qm74	5221	18	between	between	IN
cord-015021-pol2qm74	5221	19	the	the	DT
cord-015021-pol2qm74	5221	20	tissue	tissue	NN
cord-015021-pol2qm74	5221	21	distribution	distribution	NN
cord-015021-pol2qm74	5221	22	of	of	IN
cord-015021-pol2qm74	5221	23	LPS	lp	NNS
cord-015021-pol2qm74	5221	24	,	,	,
cord-015021-pol2qm74	5221	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5221	26	sensitivity	sensitivity	NN
cord-015021-pol2qm74	5221	27	and	and	CC
cord-015021-pol2qm74	5221	28	LPS	LPS	NNP
cord-015021-pol2qm74	5221	29	-	-	HYPH
cord-015021-pol2qm74	5221	30	induced	induce	VBN
cord-015021-pol2qm74	5221	31	TNF	TNF	NNP
cord-015021-pol2qm74	5221	32	production	production	NN
cord-015021-pol2qm74	5221	33	was	be	VBD
cord-015021-pol2qm74	5221	34	investigated	investigate	VBN
cord-015021-pol2qm74	5221	35	.	.	.
cord-015021-pol2qm74	5222	1	To	to	TO
cord-015021-pol2qm74	5222	2	depress	depress	VB
cord-015021-pol2qm74	5222	3	the	the	DT
cord-015021-pol2qm74	5222	4	activity	activity	NN
cord-015021-pol2qm74	5222	5	of	of	IN
cord-015021-pol2qm74	5222	6	the	the	DT
cord-015021-pol2qm74	5222	7	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5222	8	cells	cell	NNS
cord-015021-pol2qm74	5222	9	,	,	,
cord-015021-pol2qm74	5222	10	gadolinium	gadolinium	NN
cord-015021-pol2qm74	5222	11	chloride	chloride	NN
cord-015021-pol2qm74	5222	12	(	(	-LRB-
cord-015021-pol2qm74	5222	13	GdC13	GdC13	NNS
cord-015021-pol2qm74	5222	14	)	)	-RRB-
cord-015021-pol2qm74	5222	15	or	or	CC
cord-015021-pol2qm74	5222	16	carrageenan	carrageenan	NN
cord-015021-pol2qm74	5222	17	was	be	VBD
cord-015021-pol2qm74	5222	18	used	use	VBN
cord-015021-pol2qm74	5222	19	.	.	.
cord-015021-pol2qm74	5223	1	Th	th	JJ
cord-015021-pol2qm74	5223	2	~	~	NFP
cord-015021-pol2qm74	5223	3	e	e	LS
cord-015021-pol2qm74	5223	4	studies	study	NNS
cord-015021-pol2qm74	5223	5	indicate	indicate	VBP
cord-015021-pol2qm74	5223	6	the	the	DT
cord-015021-pol2qm74	5223	7	dissociation	dissociation	NN
cord-015021-pol2qm74	5223	8	of	of	IN
cord-015021-pol2qm74	5223	9	tissue	tissue	NN
cord-015021-pol2qm74	5223	10	localisation	localisation	NN
cord-015021-pol2qm74	5223	11	of	of	IN
cord-015021-pol2qm74	5223	12	Cr	Cr	NNP
cord-015021-pol2qm74	5223	13	Jllabelled	Jllabelled	NNP
cord-015021-pol2qm74	5223	14	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5223	15	and	and	CC
cord-015021-pol2qm74	5223	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5223	17	lethalithy	lethalithy	NNP
cord-015021-pol2qm74	5223	18	.	.	.
cord-015021-pol2qm74	5224	1	Both	both	DT
cord-015021-pol2qm74	5224	2	GdC13	GdC13	NNPS
cord-015021-pol2qm74	5224	3	and	and	CC
cord-015021-pol2qm74	5224	4	carrageenan	carrageenan	NN
cord-015021-pol2qm74	5224	5	depressed	depress	VBD
cord-015021-pol2qm74	5224	6	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5224	7	cell	cell	NN
cord-015021-pol2qm74	5224	8	activity	activity	NN
cord-015021-pol2qm74	5224	9	,	,	,
cord-015021-pol2qm74	5224	10	but	but	CC
cord-015021-pol2qm74	5224	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5224	12	sensitivity	sensitivity	NN
cord-015021-pol2qm74	5224	13	was	be	VBD
cord-015021-pol2qm74	5224	14	enhanced	enhance	VBN
cord-015021-pol2qm74	5224	15	only	only	RB
cord-015021-pol2qm74	5224	16	by	by	IN
cord-015021-pol2qm74	5224	17	carragenan	carragenan	NNP
cord-015021-pol2qm74	5224	18	treatment	treatment	NN
cord-015021-pol2qm74	5224	19	.	.	.
cord-015021-pol2qm74	5225	1	However	however	RB
cord-015021-pol2qm74	5225	2	,	,	,
cord-015021-pol2qm74	5225	3	there	there	EX
cord-015021-pol2qm74	5225	4	was	be	VBD
cord-015021-pol2qm74	5225	5	a	a	DT
cord-015021-pol2qm74	5225	6	close	close	JJ
cord-015021-pol2qm74	5225	7	correlation	correlation	NN
cord-015021-pol2qm74	5225	8	between	between	IN
cord-015021-pol2qm74	5225	9	the	the	DT
cord-015021-pol2qm74	5225	10	sensitivity	sensitivity	NN
cord-015021-pol2qm74	5225	11	to	to	IN
cord-015021-pol2qm74	5225	12	LPS	LPS	NNP
cord-015021-pol2qm74	5225	13	and	and	CC
cord-015021-pol2qm74	5225	14	LPS	LPS	NNP
cord-015021-pol2qm74	5225	15	-	-	HYPH
cord-015021-pol2qm74	5225	16	induced	induce	VBN
cord-015021-pol2qm74	5225	17	TNF	TNF	NNP
cord-015021-pol2qm74	5225	18	production	production	NN
cord-015021-pol2qm74	5225	19	as	as	IN
cord-015021-pol2qm74	5225	20	measured	measure	VBN
cord-015021-pol2qm74	5225	21	in	in	IN
cord-015021-pol2qm74	5225	22	the	the	DT
cord-015021-pol2qm74	5225	23	serum	serum	NN
cord-015021-pol2qm74	5225	24	,	,	,
cord-015021-pol2qm74	5225	25	since	since	IN
cord-015021-pol2qm74	5225	26	LPSinduced	LPSinduced	NNP
cord-015021-pol2qm74	5225	27	TNF	TNF	NNP
cord-015021-pol2qm74	5225	28	production	production	NN
cord-015021-pol2qm74	5225	29	was	be	VBD
cord-015021-pol2qm74	5225	30	enhanced	enhance	VBN
cord-015021-pol2qm74	5225	31	only	only	RB
cord-015021-pol2qm74	5225	32	by	by	IN
cord-015021-pol2qm74	5225	33	carrageenan	carrageenan	NN
cord-015021-pol2qm74	5225	34	treatment	treatment	NN
cord-015021-pol2qm74	5225	35	.	.	.
cord-015021-pol2qm74	5226	1	On	on	IN
cord-015021-pol2qm74	5226	2	the	the	DT
cord-015021-pol2qm74	5226	3	other	other	JJ
cord-015021-pol2qm74	5226	4	hand	hand	NN
cord-015021-pol2qm74	5226	5	,	,	,
cord-015021-pol2qm74	5226	6	GdC13	gdc13	JJ
cord-015021-pol2qm74	5226	7	pretreatment	pretreatment	NN
cord-015021-pol2qm74	5226	8	significantly	significantly	RB
cord-015021-pol2qm74	5226	9	increased	increase	VBD
cord-015021-pol2qm74	5226	10	TNF	TNF	NNP
cord-015021-pol2qm74	5226	11	production	production	NN
cord-015021-pol2qm74	5226	12	in	in	IN
cord-015021-pol2qm74	5226	13	the	the	DT
cord-015021-pol2qm74	5226	14	spleen	spleen	NN
cord-015021-pol2qm74	5226	15	.	.	.
cord-015021-pol2qm74	5227	1	These	these	DT
cord-015021-pol2qm74	5227	2	results	result	NNS
cord-015021-pol2qm74	5227	3	support	support	VBP
cord-015021-pol2qm74	5227	4	our	-PRON-	PRP$
cord-015021-pol2qm74	5227	5	earlier	early	JJR
cord-015021-pol2qm74	5227	6	findings	finding	NNS
cord-015021-pol2qm74	5227	7	that	that	IN
cord-015021-pol2qm74	5227	8	GdC13-indueed	GdC13-indueed	NNP
cord-015021-pol2qm74	5227	9	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5227	10	cell	cell	NN
cord-015021-pol2qm74	5227	11	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	5227	12	blockade	blockade	NN
cord-015021-pol2qm74	5227	13	leads	lead	NNS
cord-015021-pol2qm74	5227	14	to	to	IN
cord-015021-pol2qm74	5227	15	activation	activation	NN
cord-015021-pol2qm74	5227	16	of	of	IN
cord-015021-pol2qm74	5227	17	the	the	DT
cord-015021-pol2qm74	5227	18	spleen	spleen	NN
cord-015021-pol2qm74	5227	19	,	,	,
cord-015021-pol2qm74	5227	20	and	and	CC
cord-015021-pol2qm74	5227	21	may	may	MD
cord-015021-pol2qm74	5227	22	explain	explain	VB
cord-015021-pol2qm74	5227	23	some	some	DT
cord-015021-pol2qm74	5227	24	of	of	IN
cord-015021-pol2qm74	5227	25	the	the	DT
cord-015021-pol2qm74	5227	26	immunological	immunological	JJ
cord-015021-pol2qm74	5227	27	effects	effect	NNS
cord-015021-pol2qm74	5227	28	of	of	IN
cord-015021-pol2qm74	5227	29	GdC13	GdC13	NNS
cord-015021-pol2qm74	5227	30	.	.	.
cord-015021-pol2qm74	5228	1	Inositol(l	Inositol(l	NNS
cord-015021-pol2qm74	5229	1	,	,	,
cord-015021-pol2qm74	5229	2	4	4	CD
cord-015021-pol2qm74	5229	3	,	,	,
cord-015021-pol2qm74	5229	4	5	5	CD
cord-015021-pol2qm74	5229	5	)	)	-RRB-
cord-015021-pol2qm74	5229	6	triphosphate	triphosphate	NN
cord-015021-pol2qm74	5229	7	(	(	-LRB-
cord-015021-pol2qm74	5229	8	IP3	IP3	NNP
cord-015021-pol2qm74	5229	9	)	)	-RRB-
cord-015021-pol2qm74	5229	10	has	have	VBZ
cord-015021-pol2qm74	5229	11	been	be	VBN
cord-015021-pol2qm74	5229	12	proposed	propose	VBN
cord-015021-pol2qm74	5229	13	as	as	IN
cord-015021-pol2qm74	5229	14	a	a	DT
cord-015021-pol2qm74	5229	15	second	second	JJ
cord-015021-pol2qm74	5229	16	messenger	messenger	NN
cord-015021-pol2qm74	5229	17	for	for	IN
cord-015021-pol2qm74	5229	18	calcium	calcium	NN
cord-015021-pol2qm74	5229	19	mobilization	mobilization	NN
cord-015021-pol2qm74	5229	20	.	.	.
cord-015021-pol2qm74	5230	1	The	the	DT
cord-015021-pol2qm74	5230	2	addition	addition	NN
cord-015021-pol2qm74	5230	3	of	of	IN
cord-015021-pol2qm74	5230	4	IP3	IP3	NNP
cord-015021-pol2qm74	5230	5	at	at	IN
cord-015021-pol2qm74	5230	6	low	low	JJ
cord-015021-pol2qm74	5230	7	concentration	concentration	NN
cord-015021-pol2qm74	5230	8	has	have	VBZ
cord-015021-pol2qm74	5230	9	been	be	VBN
cord-015021-pol2qm74	5230	10	shown	show	VBN
cord-015021-pol2qm74	5230	11	to	to	TO
cord-015021-pol2qm74	5230	12	cause	cause	VB
cord-015021-pol2qm74	5230	13	calcium	calcium	NN
cord-015021-pol2qm74	5230	14	release	release	NN
cord-015021-pol2qm74	5230	15	from	from	IN
cord-015021-pol2qm74	5230	16	intracellular	intracellular	JJ
cord-015021-pol2qm74	5230	17	microsomal	microsomal	NNP
cord-015021-pol2qm74	5230	18	store	store	NN
cord-015021-pol2qm74	5230	19	in	in	IN
cord-015021-pol2qm74	5230	20	rat	rat	NN
cord-015021-pol2qm74	5230	21	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5230	22	.	.	.
cord-015021-pol2qm74	5231	1	The	the	DT
cord-015021-pol2qm74	5231	2	effects	effect	NNS
cord-015021-pol2qm74	5231	3	of	of	IN
cord-015021-pol2qm74	5231	4	sepsis	sepsis	NN
cord-015021-pol2qm74	5231	5	on	on	IN
cord-015021-pol2qm74	5231	6	the	the	DT
cord-015021-pol2qm74	5231	7	IP3	ip3	NN
cord-015021-pol2qm74	5231	8	binding	bind	VBG
cord-015021-pol2qm74	5231	9	from	from	IN
cord-015021-pol2qm74	5231	10	microsomal	microsomal	NNP
cord-015021-pol2qm74	5231	11	fraction	fraction	NN
cord-015021-pol2qm74	5231	12	of	of	IN
cord-015021-pol2qm74	5231	13	rat	rat	NN
cord-015021-pol2qm74	5231	14	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5231	15	during	during	IN
cord-015021-pol2qm74	5231	16	sepsis	sepsis	NN
cord-015021-pol2qm74	5231	17	were	be	VBD
cord-015021-pol2qm74	5231	18	investigated	investigate	VBN
cord-015021-pol2qm74	5231	19	.	.	.
cord-015021-pol2qm74	5232	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	5232	2	was	be	VBD
cord-015021-pol2qm74	5232	3	induced	induce	VBN
cord-015021-pol2qm74	5232	4	by	by	IN
cord-015021-pol2qm74	5232	5	cecal	cecal	JJ
cord-015021-pol2qm74	5232	6	ligation	ligation	NN
cord-015021-pol2qm74	5232	7	&	&	CC
cord-015021-pol2qm74	5232	8	puncture	puncture	NN
cord-015021-pol2qm74	5232	9	(	(	-LRB-
cord-015021-pol2qm74	5232	10	CLP	CLP	NNP
cord-015021-pol2qm74	5232	11	)	)	-RRB-
cord-015021-pol2qm74	5232	12	.	.	.
cord-015021-pol2qm74	5233	1	Control	control	NN
cord-015021-pol2qm74	5233	2	rats	rat	NNS
cord-015021-pol2qm74	5233	3	were	be	VBD
cord-015021-pol2qm74	5233	4	sham	sham	JJ
cord-015021-pol2qm74	5233	5	-	-	HYPH
cord-015021-pol2qm74	5233	6	operated	operate	VBN
cord-015021-pol2qm74	5233	7	.	.	.
cord-015021-pol2qm74	5234	1	Three	three	CD
cord-015021-pol2qm74	5234	2	microsomal	microsomal	NNP
cord-015021-pol2qm74	5234	3	fractions	fraction	NNS
cord-015021-pol2qm74	5234	4	(	(	-LRB-
cord-015021-pol2qm74	5234	5	rough	rough	JJ
cord-015021-pol2qm74	5234	6	,	,	,
cord-015021-pol2qm74	5234	7	intermediate	intermediate	JJ
cord-015021-pol2qm74	5234	8	and	and	CC
cord-015021-pol2qm74	5234	9	smooth	smooth	JJ
cord-015021-pol2qm74	5234	10	)	)	-RRB-
cord-015021-pol2qm74	5234	11	were	be	VBD
cord-015021-pol2qm74	5234	12	isolated	isolate	VBN
cord-015021-pol2qm74	5234	13	from	from	IN
cord-015021-pol2qm74	5234	14	rat	rat	NN
cord-015021-pol2qm74	5234	15	liver	liver	NN
cord-015021-pol2qm74	5234	16	.	.	.
cord-015021-pol2qm74	5235	1	Study	study	NN
cord-015021-pol2qm74	5235	2	of	of	IN
cord-015021-pol2qm74	5235	3	IP3	IP3	NNP
cord-015021-pol2qm74	5235	4	receptor	receptor	NN
cord-015021-pol2qm74	5235	5	binding	binding	NN
cord-015021-pol2qm74	5235	6	was	be	VBD
cord-015021-pol2qm74	5235	7	performed	perform	VBN
cord-015021-pol2qm74	5235	8	with	with	IN
cord-015021-pol2qm74	5235	9	tridium	tridium	NN
cord-015021-pol2qm74	5235	10	label	label	NN
cord-015021-pol2qm74	5235	11	IP3	IP3	NNP
cord-015021-pol2qm74	5235	12	.	.	.
cord-015021-pol2qm74	5236	1	The	the	DT
cord-015021-pol2qm74	5236	2	results	result	NNS
cord-015021-pol2qm74	5236	3	shewed	shew	VBD
cord-015021-pol2qm74	5236	4	that	that	IN
cord-015021-pol2qm74	5236	5	the	the	DT
cord-015021-pol2qm74	5236	6	IP3	IP3	NNP
cord-015021-pol2qm74	5236	7	binding	binding	NN
cord-015021-pol2qm74	5236	8	was	be	VBD
cord-015021-pol2qm74	5236	9	significantly	significantly	RB
cord-015021-pol2qm74	5236	10	depressed	depress	VBN
cord-015021-pol2qm74	5236	11	by	by	IN
cord-015021-pol2qm74	5236	12	40	40	CD
cord-015021-pol2qm74	5236	13	-	-	SYM
cord-015021-pol2qm74	5236	14	47	47	CD
cord-015021-pol2qm74	5236	15	%	%	NN
cord-015021-pol2qm74	5236	16	(	(	-LRB-
cord-015021-pol2qm74	5236	17	p<0.05	p<0.05	CD
cord-015021-pol2qm74	5236	18	)	)	-RRB-
cord-015021-pol2qm74	5236	19	during	during	IN
cord-015021-pol2qm74	5236	20	late	late	JJ
cord-015021-pol2qm74	5236	21	sepsis	sepsis	NN
cord-015021-pol2qm74	5236	22	(	(	-LRB-
cord-015021-pol2qm74	5236	23	18	18	CD
cord-015021-pol2qm74	5236	24	hrs	hrs	NN
cord-015021-pol2qm74	5236	25	after	after	IN
cord-015021-pol2qm74	5236	26	CLP	CLP	NNP
cord-015021-pol2qm74	5236	27	)	)	-RRB-
cord-015021-pol2qm74	5236	28	,	,	,
cord-015021-pol2qm74	5236	29	but	but	CC
cord-015021-pol2qm74	5236	30	not	not	RB
cord-015021-pol2qm74	5236	31	in	in	IN
cord-015021-pol2qm74	5236	32	early	early	JJ
cord-015021-pol2qm74	5236	33	sepsis	sepsis	NN
cord-015021-pol2qm74	5236	34	(	(	-LRB-
cord-015021-pol2qm74	5236	35	9	9	CD
cord-015021-pol2qm74	5236	36	hrs	hrs	NN
cord-015021-pol2qm74	5236	37	after	after	IN
cord-015021-pol2qm74	5236	38	CLP	CLP	NNP
cord-015021-pol2qm74	5236	39	)	)	-RRB-
cord-015021-pol2qm74	5236	40	.	.	.
cord-015021-pol2qm74	5237	1	The	the	DT
cord-015021-pol2qm74	5237	2	IP3	IP3	NNP
cord-015021-pol2qm74	5237	3	binding	bind	VBG
cord-015021-pol2qm74	5237	4	depression	depression	NN
cord-015021-pol2qm74	5237	5	during	during	IN
cord-015021-pol2qm74	5237	6	late	late	JJ
cord-015021-pol2qm74	5237	7	sepsis	sepsis	NN
cord-015021-pol2qm74	5237	8	was	be	VBD
cord-015021-pol2qm74	5237	9	most	most	RBS
cord-015021-pol2qm74	5237	10	significant	significant	JJ
cord-015021-pol2qm74	5237	11	on	on	IN
cord-015021-pol2qm74	5237	12	rough	rough	JJ
cord-015021-pol2qm74	5237	13	and	and	CC
cord-015021-pol2qm74	5237	14	intermediate	intermediate	JJ
cord-015021-pol2qm74	5237	15	endoplasmic	endoplasmic	NN
cord-015021-pol2qm74	5237	16	reticulum	reticulum	NN
cord-015021-pol2qm74	5237	17	(	(	-LRB-
cord-015021-pol2qm74	5237	18	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	5237	19	)	)	-RRB-
cord-015021-pol2qm74	5237	20	,	,	,
cord-015021-pol2qm74	5237	21	but	but	CC
cord-015021-pol2qm74	5237	22	not	not	RB
cord-015021-pol2qm74	5237	23	on	on	IN
cord-015021-pol2qm74	5237	24	smooth	smooth	JJ
cord-015021-pol2qm74	5237	25	subfraction	subfraction	NN
cord-015021-pol2qm74	5237	26	.	.	.
cord-015021-pol2qm74	5238	1	Since	since	IN
cord-015021-pol2qm74	5238	2	IP3	IP3	NNP
cord-015021-pol2qm74	5238	3	binding	binding	NN
cord-015021-pol2qm74	5238	4	plays	play	VBZ
cord-015021-pol2qm74	5238	5	an	an	DT
cord-015021-pol2qm74	5238	6	important	important	JJ
cord-015021-pol2qm74	5238	7	role	role	NN
cord-015021-pol2qm74	5238	8	in	in	IN
cord-015021-pol2qm74	5238	9	the	the	DT
cord-015021-pol2qm74	5238	10	regulation	regulation	NN
cord-015021-pol2qm74	5238	11	of	of	IN
cord-015021-pol2qm74	5238	12	intracellular	intracellular	JJ
cord-015021-pol2qm74	5238	13	calcium	calcium	NN
cord-015021-pol2qm74	5238	14	homeostasis	homeostasis	NN
cord-015021-pol2qm74	5238	15	in	in	IN
cord-015021-pol2qm74	5238	16	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5238	17	,	,	,
cord-015021-pol2qm74	5238	18	an	an	DT
cord-015021-pol2qm74	5238	19	impairment	impairment	NN
cord-015021-pol2qm74	5238	20	in	in	IN
cord-015021-pol2qm74	5238	21	the	the	DT
cord-015021-pol2qm74	5238	22	calcium	calcium	NN
cord-015021-pol2qm74	5238	23	release	release	NN
cord-015021-pol2qm74	5238	24	due	due	IN
cord-015021-pol2qm74	5238	25	to	to	IN
cord-015021-pol2qm74	5238	26	depressed	depressed	JJ
cord-015021-pol2qm74	5238	27	IP3	ip3	NN
cord-015021-pol2qm74	5238	28	binding	bind	VBG
cord-015021-pol2qm74	5238	29	on	on	IN
cord-015021-pol2qm74	5238	30	smooth	smooth	JJ
cord-015021-pol2qm74	5238	31	and	and	CC
cord-015021-pol2qm74	5238	32	intermediate	intermediate	JJ
cord-015021-pol2qm74	5238	33	endoplasmic	endoplasmic	NN
cord-015021-pol2qm74	5238	34	reticulum	reticulum	NN
cord-015021-pol2qm74	5238	35	during	during	IN
cord-015021-pol2qm74	5238	36	late	late	JJ
cord-015021-pol2qm74	5238	37	sepsis	sepsis	NN
cord-015021-pol2qm74	5238	38	may	may	MD
cord-015021-pol2qm74	5238	39	have	have	VB
cord-015021-pol2qm74	5238	40	a	a	DT
cord-015021-pol2qm74	5238	41	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	5238	42	significance	significance	NN
cord-015021-pol2qm74	5238	43	in	in	IN
cord-015021-pol2qm74	5238	44	contributing	contribute	VBG
cord-015021-pol2qm74	5238	45	to	to	IN
cord-015021-pol2qm74	5238	46	the	the	DT
cord-015021-pol2qm74	5238	47	development	development	NN
cord-015021-pol2qm74	5238	48	of	of	IN
cord-015021-pol2qm74	5238	49	altered	alter	VBN
cord-015021-pol2qm74	5238	50	hepatic	hepatic	JJ
cord-015021-pol2qm74	5238	51	metabolism	metabolism	NN
cord-015021-pol2qm74	5238	52	during	during	IN
cord-015021-pol2qm74	5238	53	septic	septic	JJ
cord-015021-pol2qm74	5238	54	shock	shock	NN
cord-015021-pol2qm74	5238	55	.	.	.
cord-015021-pol2qm74	5239	1	Septic	septic	JJ
cord-015021-pol2qm74	5239	2	organ	organ	NN
cord-015021-pol2qm74	5239	3	failure	failure	NN
cord-015021-pol2qm74	5239	4	is	be	VBZ
cord-015021-pol2qm74	5239	5	currently	currently	RB
cord-015021-pol2qm74	5239	6	recognized	recognize	VBN
cord-015021-pol2qm74	5239	7	as	as	IN
cord-015021-pol2qm74	5239	8	an	an	DT
cord-015021-pol2qm74	5239	9	overactivation	overactivation	NN
cord-015021-pol2qm74	5239	10	of	of	IN
cord-015021-pol2qm74	5239	11	the	the	DT
cord-015021-pol2qm74	5239	12	nonspecific	nonspecific	JJ
cord-015021-pol2qm74	5239	13	immune	immune	JJ
cord-015021-pol2qm74	5239	14	system	system	NN
cord-015021-pol2qm74	5239	15	by	by	IN
cord-015021-pol2qm74	5239	16	bacterial	bacterial	JJ
cord-015021-pol2qm74	5239	17	stimuli	stimulus	NNS
cord-015021-pol2qm74	5239	18	giving	give	VBG
cord-015021-pol2qm74	5239	19	rise	rise	NN
cord-015021-pol2qm74	5239	20	to	to	IN
cord-015021-pol2qm74	5239	21	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	5239	22	mediators	mediator	NNS
cord-015021-pol2qm74	5239	23	.	.	.
cord-015021-pol2qm74	5240	1	Little	little	JJ
cord-015021-pol2qm74	5240	2	is	be	VBZ
cord-015021-pol2qm74	5240	3	known	know	VBN
cord-015021-pol2qm74	5240	4	about	about	IN
cord-015021-pol2qm74	5240	5	the	the	DT
cord-015021-pol2qm74	5240	6	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5240	7	of	of	IN
cord-015021-pol2qm74	5240	8	the	the	DT
cord-015021-pol2qm74	5240	9	resulting	result	VBG
cord-015021-pol2qm74	5240	10	cellular	cellular	JJ
cord-015021-pol2qm74	5240	11	injury	injury	NN
cord-015021-pol2qm74	5240	12	.	.	.
cord-015021-pol2qm74	5241	1	Here	here	RB
cord-015021-pol2qm74	5241	2	,	,	,
cord-015021-pol2qm74	5241	3	a	a	DT
cord-015021-pol2qm74	5241	4	synergism	synergism	NN
cord-015021-pol2qm74	5241	5	is	be	VBZ
cord-015021-pol2qm74	5241	6	described	describe	VBN
cord-015021-pol2qm74	5241	7	between	between	IN
cord-015021-pol2qm74	5241	8	TNF	TNF	NNP
cord-015021-pol2qm74	5241	9	as	as	IN
cord-015021-pol2qm74	5241	10	a	a	DT
cord-015021-pol2qm74	5241	11	major	major	JJ
cord-015021-pol2qm74	5241	12	mediator	mediator	NN
cord-015021-pol2qm74	5241	13	of	of	IN
cord-015021-pol2qm74	5241	14	septic	septic	JJ
cord-015021-pol2qm74	5241	15	organ	organ	NN
cord-015021-pol2qm74	5241	16	injury	injury	NN
cord-015021-pol2qm74	5241	17	released	release	VBN
cord-015021-pol2qm74	5241	18	by	by	IN
cord-015021-pol2qm74	5241	19	macrophages	macrophage	NNS
cord-015021-pol2qm74	5241	20	and	and	CC
cord-015021-pol2qm74	5241	21	hydrogen	hydrogen	NN
cord-015021-pol2qm74	5241	22	peroxide	peroxide	NN
cord-015021-pol2qm74	5241	23	(	(	-LRB-
cord-015021-pol2qm74	5241	24	H202	H202	NNP
cord-015021-pol2qm74	5241	25	)	)	-RRB-
cord-015021-pol2qm74	5241	26	as	as	IN
cord-015021-pol2qm74	5241	27	a	a	DT
cord-015021-pol2qm74	5241	28	representative	representative	NN
cord-015021-pol2qm74	5241	29	of	of	IN
cord-015021-pol2qm74	5241	30	reactive	reactive	JJ
cord-015021-pol2qm74	5241	31	oxygen	oxygen	NN
cord-015021-pol2qm74	5241	32	species	specie	NNS
cord-015021-pol2qm74	5241	33	as	as	IN
cord-015021-pol2qm74	5241	34	formed	form	VBN
cord-015021-pol2qm74	5241	35	by	by	IN
cord-015021-pol2qm74	5241	36	e.g.	e.g.	JJ
cord-015021-pol2qm74	5241	37	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5241	38	.	.	.
cord-015021-pol2qm74	5242	1	Rat	rat	NN
cord-015021-pol2qm74	5242	2	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5242	3	are	be	VBP
cord-015021-pol2qm74	5242	4	only	only	RB
cord-015021-pol2qm74	5242	5	slightly	slightly	RB
cord-015021-pol2qm74	5242	6	sensitive	sensitive	JJ
cord-015021-pol2qm74	5242	7	to	to	IN
cord-015021-pol2qm74	5242	8	either	either	DT
cord-015021-pol2qm74	5242	9	agent	agent	NN
cord-015021-pol2qm74	5242	10	alone	alone	RB
cord-015021-pol2qm74	5242	11	.	.	.
cord-015021-pol2qm74	5243	1	When	when	WRB
cord-015021-pol2qm74	5243	2	treated	treat	VBN
cord-015021-pol2qm74	5243	3	with	with	IN
cord-015021-pol2qm74	5243	4	a	a	DT
cord-015021-pol2qm74	5243	5	conbination	conbination	NN
cord-015021-pol2qm74	5243	6	of	of	IN
cord-015021-pol2qm74	5243	7	TNF	TNF	NNP
cord-015021-pol2qm74	5243	8	and	and	CC
cord-015021-pol2qm74	5243	9	H#09	H#09	VBZ
cord-015021-pol2qm74	5243	10	a	a	DT
cord-015021-pol2qm74	5243	11	stronq	stronq	NN
cord-015021-pol2qm74	5243	12	synergistic	synergistic	JJ
cord-015021-pol2qm74	5243	13	toxicity	toxicity	NN
cord-015021-pol2qm74	5243	14	was	be	VBD
cord-015021-pol2qm74	5243	15	found	find	VBN
cord-015021-pol2qm74	5243	16	,	,	,
cord-015021-pol2qm74	5243	17	especially	especially	RB
cord-015021-pol2qm74	5243	18	w	w	NN
cord-015021-pol2qm74	5243	19	~	~	CD
cord-015021-pol2qm74	5243	20	e~	e~	XX
cord-015021-pol2qm74	5244	1	TNF	tnf	NN
cord-015021-pol2qm74	5244	2	-	-	HYPH
cord-015021-pol2qm74	5244	3	treatment	treatment	NN
cord-015021-pol2qm74	5244	4	preceeded	preceede	VBD
cord-015021-pol2qm74	5244	5	challenge	challenge	NN
cord-015021-pol2qm74	5244	6	with	with	IN
cord-015021-pol2qm74	5244	7	H	h	NN
cord-015021-pol2qm74	5244	8	~	~	CD
cord-015021-pol2qm74	5244	9	O~.	o~.	NN
cord-015021-pol2qm74	5245	1	We	-PRON-	PRP
cord-015021-pol2qm74	5245	2	have	have	VBP
cord-015021-pol2qm74	5245	3	recently	recently	RB
cord-015021-pol2qm74	5245	4	described	describe	VBN
cord-015021-pol2qm74	5245	5	a	a	DT
cord-015021-pol2qm74	5245	6	coculture	coculture	NN
cord-015021-pol2qm74	5245	7	model	model	NN
cord-015021-pol2qm74	5245	8	bfZrat	bfzrat	CD
cord-015021-pol2qm74	5245	9	liver	liver	NN
cord-015021-pol2qm74	5245	10	macrophaqes	macrophaqes	NN
cord-015021-pol2qm74	5245	11	and	and	CC
cord-015021-pol2qm74	5245	12	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5245	13	where	where	WRB
cord-015021-pol2qm74	5245	14	LPS	LPS	NNP
cord-015021-pol2qm74	5245	15	induces	induce	VBZ
cord-015021-pol2qm74	5245	16	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	5245	17	cell	cell	NN
cord-015021-pol2qm74	5245	18	death	death	NN
cord-015021-pol2qm74	5245	19	partially	partially	RB
cord-015021-pol2qm74	5245	20	mediated	mediate	VBN
cord-015021-pol2qm74	5245	21	by	by	IN
cord-015021-pol2qm74	5245	22	macrophage	macrophage	NN
cord-015021-pol2qm74	5245	23	TNF	TNF	NNP
cord-015021-pol2qm74	5245	24	release	release	NN
cord-015021-pol2qm74	5245	25	.	.	.
cord-015021-pol2qm74	5246	1	When	when	WRB
cord-015021-pol2qm74	5246	2	H202	H202	NNP
cord-015021-pol2qm74	5246	3	was	be	VBD
cord-015021-pol2qm74	5246	4	also	also	RB
cord-015021-pol2qm74	5246	5	employed	employ	VBN
cord-015021-pol2qm74	5246	6	in	in	IN
cord-015021-pol2qm74	5246	7	fhis	fhis	DT
cord-015021-pol2qm74	5246	8	more	more	RBR
cord-015021-pol2qm74	5246	9	complex	complex	JJ
cord-015021-pol2qm74	5246	10	cellular	cellular	JJ
cord-015021-pol2qm74	5246	11	system	system	NN
cord-015021-pol2qm74	5246	12	a	a	DT
cord-015021-pol2qm74	5246	13	similar	similar	JJ
cord-015021-pol2qm74	5246	14	synergism	synergism	NN
cord-015021-pol2qm74	5246	15	was	be	VBD
cord-015021-pol2qm74	5246	16	found	find	VBN
cord-015021-pol2qm74	5246	17	:	:	:
cord-015021-pol2qm74	5246	18	The	the	DT
cord-015021-pol2qm74	5246	19	ECc~	ECc~	NNP
cord-015021-pol2qm74	5246	20	of	of	IN
cord-015021-pol2qm74	5246	21	LPS	LPS	NNP
cord-015021-pol2qm74	5246	22	was	be	VBD
cord-015021-pol2qm74	5246	23	62	62	CD
cord-015021-pol2qm74	5246	24	consecutive	consecutive	JJ
cord-015021-pol2qm74	5246	25	patients	patient	NNS
cord-015021-pol2qm74	5246	26	with	with	IN
cord-015021-pol2qm74	5246	27	liver	liver	NN
cord-015021-pol2qm74	5246	28	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	5246	29	admitted	admit	VBD
cord-015021-pol2qm74	5246	30	to	to	IN
cord-015021-pol2qm74	5246	31	the	the	DT
cord-015021-pol2qm74	5246	32	Department	Department	NNP
cord-015021-pol2qm74	5246	33	of	of	IN
cord-015021-pol2qm74	5246	34	Surgery	Surgery	NNP
cord-015021-pol2qm74	5246	35	over	over	IN
cord-015021-pol2qm74	5246	36	a	a	DT
cord-015021-pol2qm74	5246	37	1	1	CD
cord-015021-pol2qm74	5246	38	year	year	NN
cord-015021-pol2qm74	5246	39	period	period	NN
cord-015021-pol2qm74	5246	40	from	from	IN
cord-015021-pol2qm74	5246	41	January	January	NNP
cord-015021-pol2qm74	5246	42	to	to	IN
cord-015021-pol2qm74	5246	43	December	December	NNP
cord-015021-pol2qm74	5246	44	1992	1992	CD
cord-015021-pol2qm74	5246	45	were	be	VBD
cord-015021-pol2qm74	5246	46	studied	study	VBN
cord-015021-pol2qm74	5246	47	for	for	IN
cord-015021-pol2qm74	5246	48	their	-PRON-	PRP$
cord-015021-pol2qm74	5246	49	complement	complement	NN
cord-015021-pol2qm74	5246	50	profiles	profile	NNS
cord-015021-pol2qm74	5246	51	in	in	IN
cord-015021-pol2qm74	5246	52	relation	relation	NN
cord-015021-pol2qm74	5246	53	to	to	IN
cord-015021-pol2qm74	5246	54	other	other	JJ
cord-015021-pol2qm74	5246	55	parameters	parameter	NNS
cord-015021-pol2qm74	5246	56	of	of	IN
cord-015021-pol2qm74	5246	57	liver	liver	NN
cord-015021-pol2qm74	5246	58	function	function	NN
cord-015021-pol2qm74	5246	59	,	,	,
cord-015021-pol2qm74	5246	60	The	the	DT
cord-015021-pol2qm74	5246	61	aim	aim	NN
cord-015021-pol2qm74	5246	62	of	of	IN
cord-015021-pol2qm74	5246	63	the	the	DT
cord-015021-pol2qm74	5246	64	study	study	NN
cord-015021-pol2qm74	5246	65	was	be	VBD
cord-015021-pol2qm74	5246	66	to	to	TO
cord-015021-pol2qm74	5246	67	determine	determine	VB
cord-015021-pol2qm74	5246	68	if	if	IN
cord-015021-pol2qm74	5246	69	a	a	DT
cord-015021-pol2qm74	5246	70	direct	direct	JJ
cord-015021-pol2qm74	5246	71	correlation	correlation	NN
cord-015021-pol2qm74	5246	72	existed	exist	VBD
cord-015021-pol2qm74	5246	73	between	between	IN
cord-015021-pol2qm74	5246	74	low	low	JJ
cord-015021-pol2qm74	5246	75	complement	complement	NN
cord-015021-pol2qm74	5246	76	levels	level	NNS
cord-015021-pol2qm74	5246	77	and	and	CC
cord-015021-pol2qm74	5246	78	end	end	NN
cord-015021-pol2qm74	5246	79	stage	stage	NN
cord-015021-pol2qm74	5246	80	liver	liver	NN
cord-015021-pol2qm74	5246	81	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	5246	82	.	.	.
cord-015021-pol2qm74	5247	1	Cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	5247	2	patients	patient	NNS
cord-015021-pol2qm74	5247	3	were	be	VBD
cord-015021-pol2qm74	5247	4	divided	divide	VBN
cord-015021-pol2qm74	5247	5	into	into	IN
cord-015021-pol2qm74	5247	6	Child	child	NN
cord-015021-pol2qm74	5247	7	's	's	POS
cord-015021-pol2qm74	5247	8	A	a	NN
cord-015021-pol2qm74	5247	9	,	,	,
cord-015021-pol2qm74	5247	10	B	b	NN
cord-015021-pol2qm74	5247	11	and	and	CC
cord-015021-pol2qm74	5247	12	C	c	NN
cord-015021-pol2qm74	5247	13	categories	category	NNS
cord-015021-pol2qm74	5247	14	using	use	VBG
cord-015021-pol2qm74	5247	15	Child	child	NN
cord-015021-pol2qm74	5247	16	's	's	POS
cord-015021-pol2qm74	5247	17	classification	classification	NN
cord-015021-pol2qm74	5247	18	.	.	.
cord-015021-pol2qm74	5248	1	Complement	complement	JJ
cord-015021-pol2qm74	5248	2	levels	level	NNS
cord-015021-pol2qm74	5248	3	(	(	-LRB-
cord-015021-pol2qm74	5248	4	C3	c3	NN
cord-015021-pol2qm74	5248	5	,	,	,
cord-015021-pol2qm74	5248	6	C4	C4	NNP
cord-015021-pol2qm74	5248	7	)	)	-RRB-
cord-015021-pol2qm74	5248	8	were	be	VBD
cord-015021-pol2qm74	5248	9	measured	measure	VBN
cord-015021-pol2qm74	5248	10	and	and	CC
cord-015021-pol2qm74	5248	11	functional	functional	JJ
cord-015021-pol2qm74	5248	12	assay	assay	NN
cord-015021-pol2qm74	5248	13	for	for	IN
cord-015021-pol2qm74	5248	14	complement	complement	NN
cord-015021-pol2qm74	5248	15	(	(	-LRB-
cord-015021-pol2qm74	5248	16	CH50	CH50	NNP
cord-015021-pol2qm74	5248	17	)	)	-RRB-
cord-015021-pol2qm74	5248	18	were	be	VBD
cord-015021-pol2qm74	5248	19	performed	perform	VBN
cord-015021-pol2qm74	5248	20	in	in	IN
cord-015021-pol2qm74	5248	21	each	each	DT
cord-015021-pol2qm74	5248	22	of	of	IN
cord-015021-pol2qm74	5248	23	these	these	DT
cord-015021-pol2qm74	5248	24	groupings	grouping	NNS
cord-015021-pol2qm74	5248	25	in	in	IN
cord-015021-pol2qm74	5248	26	addition	addition	NN
cord-015021-pol2qm74	5248	27	to	to	IN
cord-015021-pol2qm74	5248	28	normal	normal	JJ
cord-015021-pol2qm74	5248	29	blood	blood	NN
cord-015021-pol2qm74	5248	30	donor	donor	NN
cord-015021-pol2qm74	5248	31	controls	control	NNS
cord-015021-pol2qm74	5248	32	.	.	.
cord-015021-pol2qm74	5249	1	These	these	DT
cord-015021-pol2qm74	5249	2	results	result	NNS
cord-015021-pol2qm74	5249	3	show	show	VBP
cord-015021-pol2qm74	5249	4	that	that	IN
cord-015021-pol2qm74	5249	5	the	the	DT
cord-015021-pol2qm74	5249	6	qualitative	qualitative	JJ
cord-015021-pol2qm74	5249	7	C3	c3	NN
cord-015021-pol2qm74	5249	8	,	,	,
cord-015021-pol2qm74	5249	9	C4	C4	NNP
cord-015021-pol2qm74	5249	10	and	and	CC
cord-015021-pol2qm74	5249	11	the	the	DT
cord-015021-pol2qm74	5249	12	functional	functional	JJ
cord-015021-pol2qm74	5249	13	CHS0	CHS0	NNP
cord-015021-pol2qm74	5249	14	complement	complement	NN
cord-015021-pol2qm74	5249	15	assays	assay	NNS
cord-015021-pol2qm74	5249	16	have	have	VBP
cord-015021-pol2qm74	5249	17	good	good	JJ
cord-015021-pol2qm74	5249	18	predictive	predictive	JJ
cord-015021-pol2qm74	5249	19	values	value	NNS
cord-015021-pol2qm74	5249	20	in	in	IN
cord-015021-pol2qm74	5249	21	assessing	assess	VBG
cord-015021-pol2qm74	5249	22	deteriorating	deteriorate	VBG
cord-015021-pol2qm74	5249	23	liver	liver	NN
cord-015021-pol2qm74	5249	24	function•	function•	JJ
cord-015021-pol2qm74	5249	25	in	in	IN
cord-015021-pol2qm74	5249	26	particular	particular	JJ
cord-015021-pol2qm74	5249	27	,	,	,
cord-015021-pol2qm74	5249	28	the	the	DT
cord-015021-pol2qm74	5249	29	functional	functional	JJ
cord-015021-pol2qm74	5249	30	assay	assay	NN
cord-015021-pol2qm74	5249	31	for	for	IN
cord-015021-pol2qm74	5249	32	complement	complement	NN
cord-015021-pol2qm74	5249	33	(	(	-LRB-
cord-015021-pol2qm74	5249	34	CH50	CH50	NNP
cord-015021-pol2qm74	5249	35	)	)	-RRB-
cord-015021-pol2qm74	5249	36	showed	show	VBD
cord-015021-pol2qm74	5249	37	marked	marked	JJ
cord-015021-pol2qm74	5249	38	impairment	impairment	NN
cord-015021-pol2qm74	5249	39	in	in	IN
cord-015021-pol2qm74	5249	40	Child	child	NN
cord-015021-pol2qm74	5249	41	's	's	POS
cord-015021-pol2qm74	5249	42	C	c	NN
cord-015021-pol2qm74	5249	43	patients	patient	NNS
cord-015021-pol2qm74	5249	44	(	(	-LRB-
cord-015021-pol2qm74	5249	45	p<0.000001	p<0.000001	NN
cord-015021-pol2qm74	5249	46	)	)	-RRB-
cord-015021-pol2qm74	5249	47	confirming	confirm	VBG
cord-015021-pol2qm74	5249	48	the	the	DT
cord-015021-pol2qm74	5249	49	impaired	impair	VBN
cord-015021-pol2qm74	5249	50	immunological	immunological	JJ
cord-015021-pol2qm74	5249	51	status	status	NN
cord-015021-pol2qm74	5249	52	of	of	IN
cord-015021-pol2qm74	5249	53	these	these	DT
cord-015021-pol2qm74	5249	54	patients	patient	NNS
cord-015021-pol2qm74	5249	55	.	.	.
cord-015021-pol2qm74	5250	1	Sera	Sera	NNP
cord-015021-pol2qm74	5250	2	from	from	IN
cord-015021-pol2qm74	5250	3	this	this	DT
cord-015021-pol2qm74	5250	4	group	group	NN
cord-015021-pol2qm74	5250	5	of	of	IN
cord-015021-pol2qm74	5250	6	patients	patient	NNS
cord-015021-pol2qm74	5250	7	(	(	-LRB-
cord-015021-pol2qm74	5250	8	Child	child	NN
cord-015021-pol2qm74	5250	9	's	's	POS
cord-015021-pol2qm74	5250	10	C	c	NN
cord-015021-pol2qm74	5250	11	)	)	-RRB-
cord-015021-pol2qm74	5250	12	were	be	VBD
cord-015021-pol2qm74	5250	13	titrated	titrate	VBN
cord-015021-pol2qm74	5250	14	with	with	IN
cord-015021-pol2qm74	5250	15	pig	pig	NN
cord-015021-pol2qm74	5250	16	red	red	JJ
cord-015021-pol2qm74	5250	17	blood	blood	NN
cord-015021-pol2qm74	5250	18	cells	cell	NNS
cord-015021-pol2qm74	5250	19	(	(	-LRB-
cord-015021-pol2qm74	5250	20	RBCs	rbc	NNS
cord-015021-pol2qm74	5250	21	)	)	-RRB-
cord-015021-pol2qm74	5250	22	in	in	IN
cord-015021-pol2qm74	5250	23	a	a	DT
cord-015021-pol2qm74	5250	24	haemolytic	haemolytic	JJ
cord-015021-pol2qm74	5250	25	assay	assay	NN
cord-015021-pol2qm74	5250	26	.	.	.
cord-015021-pol2qm74	5251	1	The	the	DT
cord-015021-pol2qm74	5251	2	results	result	NNS
cord-015021-pol2qm74	5251	3	showed	show	VBD
cord-015021-pol2qm74	5251	4	that	that	IN
cord-015021-pol2qm74	5251	5	there	there	EX
cord-015021-pol2qm74	5251	6	were	be	VBD
cord-015021-pol2qm74	5251	7	significantly	significantly	RB
cord-015021-pol2qm74	5251	8	less	less	JJR
cord-015021-pol2qm74	5251	9	haemolysis	haemolysis	NN
cord-015021-pol2qm74	5251	10	of	of	IN
cord-015021-pol2qm74	5251	11	pig	pig	NN
cord-015021-pol2qm74	5251	12	RBCs	rbc	NNS
cord-015021-pol2qm74	5251	13	in	in	IN
cord-015021-pol2qm74	5251	14	these	these	DT
cord-015021-pol2qm74	5251	15	patients	patient	NNS
cord-015021-pol2qm74	5251	16	(	(	-LRB-
cord-015021-pol2qm74	5251	17	p=0.0177	p=0.0177	NNP
cord-015021-pol2qm74	5251	18	)	)	-RRB-
cord-015021-pol2qm74	5251	19	as	as	IN
cord-015021-pol2qm74	5251	20	compared	compare	VBN
cord-015021-pol2qm74	5251	21	to	to	IN
cord-015021-pol2qm74	5251	22	the	the	DT
cord-015021-pol2qm74	5251	23	controls	control	NNS
cord-015021-pol2qm74	5251	24	.	.	.
cord-015021-pol2qm74	5252	1	This	this	DT
cord-015021-pol2qm74	5252	2	findings	finding	NNS
cord-015021-pol2qm74	5252	3	strongly	strongly	RB
cord-015021-pol2qm74	5252	4	support	support	VBP
cord-015021-pol2qm74	5252	5	an	an	DT
cord-015021-pol2qm74	5252	6	impaired	impaired	JJ
cord-015021-pol2qm74	5252	7	immunological	immunological	JJ
cord-015021-pol2qm74	5252	8	status	status	NN
cord-015021-pol2qm74	5252	9	in	in	IN
cord-015021-pol2qm74	5252	10	Child	child	NN
cord-015021-pol2qm74	5252	11	's	's	POS
cord-015021-pol2qm74	5252	12	C	C	NNP
cord-015021-pol2qm74	5252	13	liver	liver	NN
cord-015021-pol2qm74	5252	14	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	5252	15	and	and	CC
cord-015021-pol2qm74	5252	16	may	may	MD
cord-015021-pol2qm74	5252	17	explain	explain	VB
cord-015021-pol2qm74	5252	18	the	the	DT
cord-015021-pol2qm74	5252	19	high	high	JJ
cord-015021-pol2qm74	5252	20	incidence	incidence	NN
cord-015021-pol2qm74	5252	21	of	of	IN
cord-015021-pol2qm74	5252	22	sepsis	sepsis	NN
cord-015021-pol2qm74	5252	23	as	as	IN
cord-015021-pol2qm74	5252	24	a	a	DT
cord-015021-pol2qm74	5252	25	terminal	terminal	JJ
cord-015021-pol2qm74	5252	26	event	event	NN
cord-015021-pol2qm74	5252	27	in	in	IN
cord-015021-pol2qm74	5252	28	these	these	DT
cord-015021-pol2qm74	5252	29	patients	patient	NNS
cord-015021-pol2qm74	5252	30	.	.	.
cord-015021-pol2qm74	5253	1	Aim	aim	VB
cord-015021-pol2qm74	5253	2	:	:	:
cord-015021-pol2qm74	5253	3	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5253	4	cells(KC	cells(kc	NN
cord-015021-pol2qm74	5253	5	)	)	-RRB-
cord-015021-pol2qm74	5253	6	have	have	VB
cord-015021-pol2qm74	5253	7	an	an	DT
cord-015021-pol2qm74	5253	8	importamt	importamt	NN
cord-015021-pol2qm74	5253	9	play	play	NN
cord-015021-pol2qm74	5253	10	to	to	TO
cord-015021-pol2qm74	5253	11	cause	cause	VB
cord-015021-pol2qm74	5253	12	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5253	13	injury	injury	NN
cord-015021-pol2qm74	5253	14	in	in	IN
cord-015021-pol2qm74	5253	15	sepsis	sepsis	NN
cord-015021-pol2qm74	5253	16	,	,	,
cord-015021-pol2qm74	5253	17	because	because	IN
cord-015021-pol2qm74	5253	18	these	these	DT
cord-015021-pol2qm74	5253	19	cells	cell	NNS
cord-015021-pol2qm74	5253	20	release	release	VBP
cord-015021-pol2qm74	5253	21	many	many	JJ
cord-015021-pol2qm74	5253	22	kinds	kind	NNS
cord-015021-pol2qm74	5253	23	of	of	IN
cord-015021-pol2qm74	5253	24	substances	substance	NNS
cord-015021-pol2qm74	5253	25	.	.	.
cord-015021-pol2qm74	5254	1	We	-PRON-	PRP
cord-015021-pol2qm74	5254	2	reported	report	VBD
cord-015021-pol2qm74	5254	3	that	that	IN
cord-015021-pol2qm74	5254	4	oxygem	oxygem	NNP
cord-015021-pol2qm74	5254	5	radicals	radical	NNS
cord-015021-pol2qm74	5254	6	released	release	VBN
cord-015021-pol2qm74	5254	7	by	by	IN
cord-015021-pol2qm74	5254	8	KCs	kc	NNS
cord-015021-pol2qm74	5254	9	stimulated	stimulate	VBN
cord-015021-pol2qm74	5254	10	by	by	IN
cord-015021-pol2qm74	5254	11	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	5254	12	(	(	-LRB-
cord-015021-pol2qm74	5254	13	LPS	LPS	NNP
cord-015021-pol2qm74	5254	14	)	)	-RRB-
cord-015021-pol2qm74	5254	15	caused	cause	VBD
cord-015021-pol2qm74	5254	16	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5254	17	injury	injury	NN
cord-015021-pol2qm74	5254	18	.	.	.
cord-015021-pol2qm74	5255	1	Aim	aim	VB
cord-015021-pol2qm74	5255	2	of	of	IN
cord-015021-pol2qm74	5255	3	this	this	DT
cord-015021-pol2qm74	5255	4	study	study	NN
cord-015021-pol2qm74	5255	5	is	be	VBZ
cord-015021-pol2qm74	5255	6	to	to	TO
cord-015021-pol2qm74	5255	7	investigate	investigate	VB
cord-015021-pol2qm74	5255	8	the	the	DT
cord-015021-pol2qm74	5255	9	relationship	relationship	NN
cord-015021-pol2qm74	5255	10	between	between	IN
cord-015021-pol2qm74	5255	11	imtracellmlar	imtracellmlar	NNP
cord-015021-pol2qm74	5255	12	calcium(Ca	calcium(ca	NN
cord-015021-pol2qm74	5255	13	)	)	-RRB-
cord-015021-pol2qm74	5255	14	concentration	concentration	NN
cord-015021-pol2qm74	5255	15	of	of	IN
cord-015021-pol2qm74	5255	16	cultured	cultured	JJ
cord-015021-pol2qm74	5255	17	rat	rat	NN
cord-015021-pol2qm74	5255	18	KCs	kc	NNS
cord-015021-pol2qm74	5255	19	stimulated	stimulate	VBN
cord-015021-pol2qm74	5255	20	by	by	IN
cord-015021-pol2qm74	5255	21	LPS	LPS	NNP
cord-015021-pol2qm74	5255	22	and	and	CC
cord-015021-pol2qm74	5255	23	release	release	NN
cord-015021-pol2qm74	5255	24	of	of	IN
cord-015021-pol2qm74	5255	25	oxygen	oxygen	NN
cord-015021-pol2qm74	5255	26	radicals	radical	NNS
cord-015021-pol2qm74	5255	27	,	,	,
cord-015021-pol2qm74	5255	28	and	and	CC
cord-015021-pol2qm74	5255	29	effect	effect	NN
cord-015021-pol2qm74	5255	30	of	of	IN
cord-015021-pol2qm74	5255	31	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	5255	32	E~	E~	NNS
cord-015021-pol2qm74	5255	33	(	(	-LRB-
cord-015021-pol2qm74	5255	34	PGE~	PGE~	NNP
cord-015021-pol2qm74	5255	35	)	)	-RRB-
cord-015021-pol2qm74	5255	36	on	on	IN
cord-015021-pol2qm74	5255	37	imtracellular	imtracellular	NNP
cord-015021-pol2qm74	5256	1	Ca	ca	RB
cord-015021-pol2qm74	5256	2	concentration	concentration	NN
cord-015021-pol2qm74	5256	3	.	.	.
cord-015021-pol2qm74	5257	1	Production	production	NN
cord-015021-pol2qm74	5257	2	of	of	IN
cord-015021-pol2qm74	5257	3	acute	acute	JJ
cord-015021-pol2qm74	5257	4	phase	phase	NN
cord-015021-pol2qm74	5257	5	proteins	protein	NNS
cord-015021-pol2qm74	5257	6	(	(	-LRB-
cord-015021-pol2qm74	5257	7	C	c	NN
cord-015021-pol2qm74	5257	8	-	-	HYPH
cord-015021-pol2qm74	5257	9	reactive	reactive	JJ
cord-015021-pol2qm74	5257	10	protein	protein	NN
cord-015021-pol2qm74	5257	11	,	,	,
cord-015021-pol2qm74	5257	12	CRP	CRP	NNP
cord-015021-pol2qm74	5257	13	,	,	,
cord-015021-pol2qm74	5257	14	transferrin	transferrin	NN
cord-015021-pol2qm74	5257	15	,	,	,
cord-015021-pol2qm74	5257	16	Tf	Tf	NNP
cord-015021-pol2qm74	5257	17	)	)	-RRB-
cord-015021-pol2qm74	5257	18	and	and	CC
cord-015021-pol2qm74	5257	19	£	£	$
cord-015021-pol2qm74	5257	20	erritin	erritin	NNS
cord-015021-pol2qm74	5257	21	(	(	-LRB-
cord-015021-pol2qm74	5257	22	F	F	NNP
cord-015021-pol2qm74	5257	23	)	)	-RRB-
cord-015021-pol2qm74	5257	24	in	in	IN
cord-015021-pol2qm74	5257	25	rat	rat	NN
cord-015021-pol2qm74	5257	26	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5257	27	(	(	-LRB-
cord-015021-pol2qm74	5257	28	Hps	Hps	NNP
cord-015021-pol2qm74	5257	29	)	)	-RRB-
cord-015021-pol2qm74	5257	30	and	and	CC
cord-015021-pol2qm74	5257	31	its	-PRON-	PRP$
cord-015021-pol2qm74	5257	32	dependence	dependence	NN
cord-015021-pol2qm74	5257	33	on	on	IN
cord-015021-pol2qm74	5257	34	extracellular	extracellular	JJ
cord-015021-pol2qm74	5257	35	matrix	matrix	NN
cord-015021-pol2qm74	5257	36	components	component	NNS
cord-015021-pol2qm74	5257	37	were	be	VBD
cord-015021-pol2qm74	5257	38	studied	study	VBN
cord-015021-pol2qm74	5257	39	.	.	.
cord-015021-pol2qm74	5258	1	Hps	Hps	NNP
cord-015021-pol2qm74	5258	2	isolated	isolate	VBN
cord-015021-pol2qm74	5258	3	from	from	IN
cord-015021-pol2qm74	5258	4	the	the	DT
cord-015021-pol2qm74	5258	5	liver	liver	NN
cord-015021-pol2qm74	5258	6	by	by	IN
cord-015021-pol2qm74	5258	7	collagenase	collagenase	NNP
cord-015021-pol2qm74	5258	8	perfusion	perfusion	NN
cord-015021-pol2qm74	5258	9	were	be	VBD
cord-015021-pol2qm74	5258	10	cultured	culture	VBN
cord-015021-pol2qm74	5258	11	at	at	IN
cord-015021-pol2qm74	5258	12	~O5	~o5	CD
cord-015021-pol2qm74	5258	13	per	per	IN
cord-015021-pol2qm74	5258	14	0.5	0.5	CD
cord-015021-pol2qm74	5258	15	ml	ml	NN
cord-015021-pol2qm74	5258	16	medium	medium	JJ
cord-015021-pol2qm74	5258	17	FI2+DMEM	fi2+dmem	NN
cord-015021-pol2qm74	5259	1	(	(	-LRB-
cord-015021-pol2qm74	5259	2	1:1	1:1	LS
cord-015021-pol2qm74	5259	3	)	)	-RRB-
cord-015021-pol2qm74	5259	4	with	with	IN
cord-015021-pol2qm74	5259	5	10	10	CD
cord-015021-pol2qm74	5259	6	%	%	NN
cord-015021-pol2qm74	5259	7	fetal	fetal	JJ
cord-015021-pol2qm74	5259	8	calf	calf	NN
cord-015021-pol2qm74	5259	9	serum	serum	NN
cord-015021-pol2qm74	5259	10	for	for	IN
cord-015021-pol2qm74	5259	11	2	2	CD
cord-015021-pol2qm74	5259	12	days	day	NNS
cord-015021-pol2qm74	5259	13	on	on	IN
cord-015021-pol2qm74	5259	14	uncoated	uncoated	JJ
cord-015021-pol2qm74	5259	15	or	or	CC
cord-015021-pol2qm74	5259	16	type	type	NN
cord-015021-pol2qm74	5260	1	I	-PRON-	PRP
cord-015021-pol2qm74	5260	2	collagen	collagen	NN
cord-015021-pol2qm74	5260	3	coated	coat	VBN
cord-015021-pol2qm74	5260	4	plastic	plastic	NN
cord-015021-pol2qm74	5260	5	surface	surface	NN
cord-015021-pol2qm74	5260	6	or	or	CC
cord-015021-pol2qm74	5260	7	in	in	IN
cord-015021-pol2qm74	5260	8	the	the	DT
cord-015021-pol2qm74	5260	9	presence	presence	NN
cord-015021-pol2qm74	5260	10	of	of	IN
cord-015021-pol2qm74	5260	11	dextrane	dextrane	NNP
cord-015021-pol2qm74	5260	12	sulphate	sulphate	NN
cord-015021-pol2qm74	5260	13	in	in	IN
cord-015021-pol2qm74	5260	14	the	the	DT
cord-015021-pol2qm74	5260	15	medium	medium	NN
cord-015021-pol2qm74	5260	16	.	.	.
cord-015021-pol2qm74	5261	1	Hps	Hps	NNP
cord-015021-pol2qm74	5261	2	were	be	VBD
cord-015021-pol2qm74	5261	3	stimulated	stimulate	VBN
cord-015021-pol2qm74	5261	4	by	by	IN
cord-015021-pol2qm74	5261	5	conditioned	condition	VBN
cord-015021-pol2qm74	5261	6	medium	medium	NN
cord-015021-pol2qm74	5261	7	(	(	-LRB-
cord-015021-pol2qm74	5261	8	GM	GM	NNP
cord-015021-pol2qm74	5261	9	)	)	-RRB-
cord-015021-pol2qm74	5261	10	from	from	IN
cord-015021-pol2qm74	5261	11	I	I	NNP
cord-015021-pol2qm74	5261	12	~	~	CD
cord-015021-pol2qm74	5261	13	IA	IA	NNP
cord-015021-pol2qm74	5261	14	-	-	HYPH
cord-015021-pol2qm74	5261	15	P	P	NNP
cord-015021-pol2qm74	5261	16	or	or	CC
cord-015021-pol2qm74	5261	17	E.	E.	NNP
cord-015021-pol2qm74	5261	18	coli	coli	VBZ
cord-015021-pol2qm74	5261	19	LPS	LPS	NNP
cord-015021-pol2qm74	5261	20	preineubated	preineubate	VBD
cord-015021-pol2qm74	5261	21	human	human	JJ
cord-015021-pol2qm74	5261	22	blood	blood	NN
cord-015021-pol2qm74	5261	23	mononuclear	mononuclear	NN
cord-015021-pol2qm74	5261	24	cells	cell	NNS
cord-015021-pol2qm74	5261	25	.	.	.
cord-015021-pol2qm74	5262	1	Production	production	NN
cord-015021-pol2qm74	5262	2	of	of	IN
cord-015021-pol2qm74	5262	3	CRP	CRP	NNP
cord-015021-pol2qm74	5262	4	,	,	,
cord-015021-pol2qm74	5262	5	Tf	Tf	NNP
cord-015021-pol2qm74	5262	6	and	and	CC
cord-015021-pol2qm74	5262	7	F	F	NNP
cord-015021-pol2qm74	5262	8	by	by	IN
cord-015021-pol2qm74	5262	9	Hps	Hps	NNP
cord-015021-pol2qm74	5262	10	was	be	VBD
cord-015021-pol2qm74	5262	11	detected	detect	VBN
cord-015021-pol2qm74	5262	12	by	by	IN
cord-015021-pol2qm74	5262	13	ELiSA	ELiSA	NNP
cord-015021-pol2qm74	5262	14	.	.	.
cord-015021-pol2qm74	5263	1	It	-PRON-	PRP
cord-015021-pol2qm74	5263	2	was	be	VBD
cord-015021-pol2qm74	5263	3	found	find	VBN
cord-015021-pol2qm74	5263	4	that	that	IN
cord-015021-pol2qm74	5263	5	both	both	DT
cord-015021-pol2qm74	5263	6	CMs	cm	NNS
cord-015021-pol2qm74	5263	7	decreased	decrease	VBD
cord-015021-pol2qm74	5263	8	Tf	Tf	NNP
cord-015021-pol2qm74	5263	9	synthesis	synthesis	NN
cord-015021-pol2qm74	5263	10	in	in	IN
cord-015021-pol2qm74	5263	11	Hps	Hps	NNP
cord-015021-pol2qm74	5263	12	by	by	IN
cord-015021-pol2qm74	5263	13	15	15	CD
cord-015021-pol2qm74	5263	14	-	-	SYM
cord-015021-pol2qm74	5263	15	50	50	CD
cord-015021-pol2qm74	5263	16	%	%	NN
cord-015021-pol2qm74	5263	17	(	(	-LRB-
cord-015021-pol2qm74	5263	18	p	p	NN
cord-015021-pol2qm74	5263	19	<	<	XX
cord-015021-pol2qm74	5263	20	O.OS	O.OS	NNP
cord-015021-pol2qm74	5263	21	)	)	-RRB-
cord-015021-pol2qm74	5263	22	.	.	.
cord-015021-pol2qm74	5264	1	The	the	DT
cord-015021-pol2qm74	5264	2	level	level	NN
cord-015021-pol2qm74	5264	3	of	of	IN
cord-015021-pol2qm74	5264	4	F	F	NNP
cord-015021-pol2qm74	5264	5	synthesis	synthesis	NN
cord-015021-pol2qm74	5264	6	did	do	VBD
cord-015021-pol2qm74	5264	7	n't	not	RB
cord-015021-pol2qm74	5264	8	change	change	VB
cord-015021-pol2qm74	5264	9	or	or	CC
cord-015021-pol2qm74	5264	10	only	only	RB
cord-015021-pol2qm74	5264	11	slightly	slightly	RB
cord-015021-pol2qm74	5264	12	decreased	decrease	VBD
cord-015021-pol2qm74	5264	13	.	.	.
cord-015021-pol2qm74	5265	1	The	the	DT
cord-015021-pol2qm74	5265	2	addition	addition	NN
cord-015021-pol2qm74	5265	3	of	of	IN
cord-015021-pol2qm74	5265	4	CMs	cms	NN
cord-015021-pol2qm74	5265	5	led	lead	VBD
cord-015021-pol2qm74	5265	6	to	to	IN
cord-015021-pol2qm74	5265	7	the	the	DT
cord-015021-pol2qm74	5265	8	enhancement	enhancement	NN
cord-015021-pol2qm74	5265	9	of	of	IN
cord-015021-pol2qm74	5265	10	CRP	crp	NN
cord-015021-pol2qm74	5265	11	synthesis	synthesis	NN
cord-015021-pol2qm74	5265	12	more	more	JJR
cord-015021-pol2qm74	5265	13	than	than	IN
cord-015021-pol2qm74	5265	14	2.5	2.5	CD
cord-015021-pol2qm74	5265	15	times	time	NNS
cord-015021-pol2qm74	5265	16	.	.	.
cord-015021-pol2qm74	5266	1	The	the	DT
cord-015021-pol2qm74	5266	2	most	most	RBS
cord-015021-pol2qm74	5266	3	reproducible	reproducible	JJ
cord-015021-pol2qm74	5266	4	results	result	NNS
cord-015021-pol2qm74	5266	5	were	be	VBD
cord-015021-pol2qm74	5266	6	obtained	obtain	VBN
cord-015021-pol2qm74	5266	7	when	when	WRB
cord-015021-pol2qm74	5266	8	plastics	plastic	NNS
cord-015021-pol2qm74	5266	9	had	have	VBD
cord-015021-pol2qm74	5266	10	been	be	VBN
cord-015021-pol2qm74	5266	11	coated	coat	VBN
cord-015021-pol2qm74	5266	12	with	with	IN
cord-015021-pol2qm74	5266	13	collagen	collagen	NN
cord-015021-pol2qm74	5266	14	.	.	.
cord-015021-pol2qm74	5267	1	Dextran	dextran	NN
cord-015021-pol2qm74	5267	2	sulphate	sulphate	NN
cord-015021-pol2qm74	5267	3	markedly	markedly	RB
cord-015021-pol2qm74	5267	4	increased	increase	VBD
cord-015021-pol2qm74	5267	5	CRP	crp	NN
cord-015021-pol2qm74	5267	6	synthesis	synthesis	NN
cord-015021-pol2qm74	5267	7	.	.	.
cord-015021-pol2qm74	5268	1	Thus	thus	RB
cord-015021-pol2qm74	5268	2	using	use	VBG
cord-015021-pol2qm74	5268	3	this	this	DT
cord-015021-pol2qm74	5268	4	model	model	NN
cord-015021-pol2qm74	5268	5	of	of	IN
cord-015021-pol2qm74	5268	6	an	an	DT
cord-015021-pol2qm74	5268	7	acute	acute	JJ
cord-015021-pol2qm74	5268	8	phase	phase	NN
cord-015021-pol2qm74	5268	9	reaction	reaction	NN
cord-015021-pol2qm74	5268	10	in	in	IN
cord-015021-pol2qm74	5268	11	vitro	vitro	FW
cord-015021-pol2qm74	5268	12	we	-PRON-	PRP
cord-015021-pol2qm74	5268	13	found	find	VBD
cord-015021-pol2qm74	5268	14	the	the	DT
cord-015021-pol2qm74	5268	15	enhancement	enhancement	NN
cord-015021-pol2qm74	5268	16	of	of	IN
cord-015021-pol2qm74	5268	17	CRP	crp	NN
cord-015021-pol2qm74	5268	18	synthesis	synthesis	NN
cord-015021-pol2qm74	5268	19	and	and	CC
cord-015021-pol2qm74	5268	20	the	the	DT
cord-015021-pol2qm74	5268	21	decrease	decrease	NN
cord-015021-pol2qm74	5268	22	of	of	IN
cord-015021-pol2qm74	5268	23	Tf	Tf	NNP
cord-015021-pol2qm74	5268	24	synthesis	synthesis	NN
cord-015021-pol2qm74	5268	25	.	.	.
cord-015021-pol2qm74	5269	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	5269	2	data	datum	NNS
cord-015021-pol2qm74	5269	3	correspond	correspond	VBP
cord-015021-pol2qm74	5269	4	with	with	IN
cord-015021-pol2qm74	5269	5	nublished	nublished	JJ
cord-015021-pol2qm74	5269	6	materials	material	NNS
cord-015021-pol2qm74	5269	7	on	on	IN
cord-015021-pol2qm74	5269	8	the	the	DT
cord-015021-pol2qm74	5269	9	acute	acute	JJ
cord-015021-pol2qm74	5269	10	phase	phase	NN
cord-015021-pol2qm74	5269	11	in	in	IN
cord-015021-pol2qm74	5269	12	vivo	vivo	NN
cord-015021-pol2qm74	5269	13	and	and	CC
cord-015021-pol2qm74	5269	14	point	point	NN
cord-015021-pol2qm74	5269	15	to	to	IN
cord-015021-pol2qm74	5269	16	relevance	relevance	NN
cord-015021-pol2qm74	5269	17	of	of	IN
cord-015021-pol2qm74	5269	18	the	the	DT
cord-015021-pol2qm74	5269	19	proposed	propose	VBN
cord-015021-pol2qm74	5269	20	model	model	NN
cord-015021-pol2qm74	5269	21	.	.	.
cord-015021-pol2qm74	5270	1	Metabolism	metabolism	NN
cord-015021-pol2qm74	5270	2	of	of	IN
cord-015021-pol2qm74	5270	3	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5270	4	under	under	IN
cord-015021-pol2qm74	5270	5	traumatic	traumatic	JJ
cord-015021-pol2qm74	5270	6	illness	illness	NN
cord-015021-pol2qm74	5270	7	has	have	VBZ
cord-015021-pol2qm74	5270	8	not	not	RB
cord-015021-pol2qm74	5270	9	been	be	VBN
cord-015021-pol2qm74	5270	10	sufficiently	sufficiently	RB
cord-015021-pol2qm74	5270	11	investigated	investigate	VBN
cord-015021-pol2qm74	5270	12	.	.	.
cord-015021-pol2qm74	5271	1	Therefore	therefore	RB
cord-015021-pol2qm74	5271	2	we	-PRON-	PRP
cord-015021-pol2qm74	5271	3	have	have	VBP
cord-015021-pol2qm74	5271	4	applied	apply	VBN
cord-015021-pol2qm74	5271	5	absorption	absorption	NN
cord-015021-pol2qm74	5271	6	and	and	CC
cord-015021-pol2qm74	5271	7	fluorescent	fluorescent	JJ
cord-015021-pol2qm74	5271	8	cytophotometry	cytophotometry	NN
cord-015021-pol2qm74	5271	9	techniques	technique	NNS
cord-015021-pol2qm74	5271	10	to	to	TO
cord-015021-pol2qm74	5271	11	study	study	VB
cord-015021-pol2qm74	5271	12	the	the	DT
cord-015021-pol2qm74	5271	13	content	content	NN
cord-015021-pol2qm74	5271	14	of	of	IN
cord-015021-pol2qm74	5271	15	RNA	RNA	NNP
cord-015021-pol2qm74	5271	16	,	,	,
cord-015021-pol2qm74	5271	17	glycogen	glycogen	NNP
cord-015021-pol2qm74	5271	18	and	and	CC
cord-015021-pol2qm74	5271	19	its	-PRON-	PRP$
cord-015021-pol2qm74	5271	20	fractions	fraction	NNS
cord-015021-pol2qm74	5271	21	in	in	IN
cord-015021-pol2qm74	5271	22	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5271	23	of	of	IN
cord-015021-pol2qm74	5271	24	patients	patient	NNS
cord-015021-pol2qm74	5271	25	with	with	IN
cord-015021-pol2qm74	5271	26	severe	severe	JJ
cord-015021-pol2qm74	5271	27	mechanical	mechanical	JJ
cord-015021-pol2qm74	5271	28	trauma	trauma	NN
cord-015021-pol2qm74	5271	29	,	,	,
cord-015021-pol2qm74	5271	30	both	both	CC
cord-015021-pol2qm74	5271	31	with	with	IN
cord-015021-pol2qm74	5271	32	and	and	CC
cord-015021-pol2qm74	5271	33	without	without	IN
cord-015021-pol2qm74	5271	34	endointoxication	endointoxication	NN
cord-015021-pol2qm74	5271	35	at	at	IN
cord-015021-pol2qm74	5271	36	various	various	JJ
cord-015021-pol2qm74	5271	37	stages	stage	NNS
cord-015021-pol2qm74	5271	38	.	.	.
cord-015021-pol2qm74	5272	1	For	for	IN
cord-015021-pol2qm74	5272	2	these	these	DT
cord-015021-pol2qm74	5272	3	purposes	purpose	NNS
cord-015021-pol2qm74	5272	4	slides	slide	NNS
cord-015021-pol2qm74	5272	5	were	be	VBD
cord-015021-pol2qm74	5272	6	prepared	prepare	VBN
cord-015021-pol2qm74	5272	7	from	from	IN
cord-015021-pol2qm74	5272	8	the	the	DT
cord-015021-pol2qm74	5272	9	repeated	repeat	VBN
cord-015021-pol2qm74	5272	10	aspiration	aspiration	NN
cord-015021-pol2qm74	5272	11	biopsy	biopsy	NN
cord-015021-pol2qm74	5272	12	material	material	NN
cord-015021-pol2qm74	5272	13	according	accord	VBG
cord-015021-pol2qm74	5272	14	to	to	IN
cord-015021-pol2qm74	5272	15	special	special	JJ
cord-015021-pol2qm74	5272	16	techniques	technique	NNS
cord-015021-pol2qm74	5272	17	(	(	-LRB-
cord-015021-pol2qm74	5272	18	Kudryavtseva	Kudryavtseva	NNP
cord-015021-pol2qm74	5272	19	et	et	NNP
cord-015021-pol2qm74	5272	20	al	al	NNP
cord-015021-pol2qm74	5272	21	.	.	NNP
cord-015021-pol2qm74	5272	22	,	,	,
cord-015021-pol2qm74	5272	23	1983	1983	CD
cord-015021-pol2qm74	5272	24	)	)	-RRB-
cord-015021-pol2qm74	5272	25	.	.	.
cord-015021-pol2qm74	5273	1	Slides	slide	NNS
cord-015021-pol2qm74	5273	2	were	be	VBD
cord-015021-pol2qm74	5273	3	stained	stain	VBN
cord-015021-pol2qm74	5273	4	by	by	IN
cord-015021-pol2qm74	5273	5	gallocyanin	gallocyanin	NN
cord-015021-pol2qm74	5273	6	-	-	HYPH
cord-015021-pol2qm74	5273	7	chromalum	chromalum	NN
cord-015021-pol2qm74	5273	8	to	to	TO
cord-015021-pol2qm74	5273	9	measure	measure	VB
cord-015021-pol2qm74	5273	10	RNA	RNA	NNP
cord-015021-pol2qm74	5273	11	or	or	CC
cord-015021-pol2qm74	5273	12	underwent	undergo	VBD
cord-015021-pol2qm74	5273	13	fluorescent	fluorescent	JJ
cord-015021-pol2qm74	5273	14	PAS	pas	NN
cord-015021-pol2qm74	5273	15	-	-	HYPH
cord-015021-pol2qm74	5273	16	reaction	reaction	NN
cord-015021-pol2qm74	5273	17	to	to	TO
cord-015021-pol2qm74	5273	18	measure	measure	VB
cord-015021-pol2qm74	5273	19	glycogen	glycogen	NN
cord-015021-pol2qm74	5273	20	and	and	CC
cord-015021-pol2qm74	5273	21	its	-PRON-	PRP$
cord-015021-pol2qm74	5273	22	fractions	fraction	NNS
cord-015021-pol2qm74	5273	23	(	(	-LRB-
cord-015021-pol2qm74	5273	24	Kudryavtseva	Kudryavtseva	NNP
cord-015021-pol2qm74	5273	25	et	et	NNP
cord-015021-pol2qm74	5273	26	al	al	NNP
cord-015021-pol2qm74	5273	27	.	.	NNP
cord-015021-pol2qm74	5273	28	,	,	,
cord-015021-pol2qm74	5273	29	1970	1970	CD
cord-015021-pol2qm74	5274	1	(	(	-LRB-
cord-015021-pol2qm74	5274	2	Kudryavtseva	Kudryavtseva	NNP
cord-015021-pol2qm74	5274	3	et	et	NNP
cord-015021-pol2qm74	5274	4	al	al	NNP
cord-015021-pol2qm74	5274	5	.	.	.
cord-015021-pol2qm74	5275	1	,	,	,
cord-015021-pol2qm74	5275	2	,	,	,
cord-015021-pol2qm74	5275	3	1974	1974	CD
cord-015021-pol2qm74	5275	4	 	 	_SP
cord-015021-pol2qm74	5276	1	The	the	DT
cord-015021-pol2qm74	5276	2	ability	ability	NN
cord-015021-pol2qm74	5276	3	of	of	IN
cord-015021-pol2qm74	5276	4	02	02	CD
cord-015021-pol2qm74	5276	5	metabolites	metabolite	NNS
cord-015021-pol2qm74	5276	6	derived	derive	VBN
cord-015021-pol2qm74	5276	7	from	from	IN
cord-015021-pol2qm74	5276	8	the	the	DT
cord-015021-pol2qm74	5276	9	xanthine	xanthine	NN
cord-015021-pol2qm74	5276	10	-	-	HYPH
cord-015021-pol2qm74	5276	11	xanthine	xanthine	NN
cord-015021-pol2qm74	5276	12	oxidase	oxidase	NN
cord-015021-pol2qm74	5276	13	system	system	NN
cord-015021-pol2qm74	5276	14	to	to	TO
cord-015021-pol2qm74	5276	15	inhibit	inhibit	VB
cord-015021-pol2qm74	5276	16	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5276	17	function	function	NN
cord-015021-pol2qm74	5276	18	was	be	VBD
cord-015021-pol2qm74	5276	19	examined	examine	VBN
cord-015021-pol2qm74	5276	20	using	use	VBG
cord-015021-pol2qm74	5276	21	freshly	freshly	RB
cord-015021-pol2qm74	5276	22	isolated	isolate	VBN
cord-015021-pol2qm74	5276	23	rat	rat	NN
cord-015021-pol2qm74	5276	24	liver	liver	NN
cord-015021-pol2qm74	5276	25	mitochondria	mitochondrion	NNS
cord-015021-pol2qm74	5276	26	.	.	.
cord-015021-pol2qm74	5277	1	Under	under	IN
cord-015021-pol2qm74	5277	2	uncoupled	uncoupled	JJ
cord-015021-pol2qm74	5277	3	conditions	condition	NNS
cord-015021-pol2qm74	5277	4	,	,	,
cord-015021-pol2qm74	5277	5	mitochondria	mitochondrion	NNS
cord-015021-pol2qm74	5277	6	exposed	expose	VBN
cord-015021-pol2qm74	5277	7	to	to	IN
cord-015021-pol2qm74	5277	8	free	free	JJ
cord-015021-pol2qm74	5277	9	radicals	radical	NNS
cord-015021-pol2qm74	5277	10	exhibited	exhibit	VBD
cord-015021-pol2qm74	5277	11	a	a	DT
cord-015021-pol2qm74	5277	12	significant	significant	JJ
cord-015021-pol2qm74	5277	13	decrease	decrease	NN
cord-015021-pol2qm74	5277	14	in	in	IN
cord-015021-pol2qm74	5277	15	02	02	CD
cord-015021-pol2qm74	5277	16	consumption	consumption	NN
cord-015021-pol2qm74	5277	17	supported	support	VBN
cord-015021-pol2qm74	5277	18	by	by	IN
cord-015021-pol2qm74	5277	19	NAD+-Iinked	nad+-iinked	JJ
cord-015021-pol2qm74	5277	20	substrates	substrate	NNS
cord-015021-pol2qm74	5277	21	,	,	,
cord-015021-pol2qm74	5277	22	but	but	CC
cord-015021-pol2qm74	5277	23	showed	show	VBD
cord-015021-pol2qm74	5277	24	almost	almost	RB
cord-015021-pol2qm74	5277	25	no	no	DT
cord-015021-pol2qm74	5277	26	change	change	NN
cord-015021-pol2qm74	5277	27	in	in	IN
cord-015021-pol2qm74	5277	28	02	02	CD
cord-015021-pol2qm74	5277	29	consumption	consumption	NN
cord-015021-pol2qm74	5277	30	in	in	IN
cord-015021-pol2qm74	5277	31	the	the	DT
cord-015021-pol2qm74	5277	32	presence	presence	NN
cord-015021-pol2qm74	5277	33	of	of	IN
cord-015021-pol2qm74	5277	34	succinate	succinate	NNP
cord-015021-pol2qm74	5277	35	and	and	CC
cord-015021-pol2qm74	5277	36	ascorbate	ascorbate	NN
cord-015021-pol2qm74	5277	37	.	.	.
cord-015021-pol2qm74	5278	1	The	the	DT
cord-015021-pol2qm74	5278	2	activity	activity	NN
cord-015021-pol2qm74	5278	3	of	of	IN
cord-015021-pol2qm74	5278	4	electron	electron	NN
cord-015021-pol2qm74	5278	5	transfer	transfer	NN
cord-015021-pol2qm74	5278	6	complex	complex	NN
cord-015021-pol2qm74	5278	7	I	i	NN
cord-015021-pol2qm74	5278	8	(	(	-LRB-
cord-015021-pol2qm74	5278	9	NADH	NADH	NNP
cord-015021-pol2qm74	5278	10	oxidase	oxidase	NN
cord-015021-pol2qm74	5278	11	and	and	CC
cord-015021-pol2qm74	5278	12	NADH	NADH	NNP
cord-015021-pol2qm74	5278	13	-	-	HYPH
cord-015021-pol2qm74	5278	14	cytochrome	cytochrome	NNP
cord-015021-pol2qm74	5278	15	c	c	NN
cord-015021-pol2qm74	5278	16	oxidoreductase	oxidoreductase	NN
cord-015021-pol2qm74	5278	17	)	)	-RRB-
cord-015021-pol2qm74	5278	18	and	and	CC
cord-015021-pol2qm74	5278	19	the	the	DT
cord-015021-pol2qm74	5278	20	energy	energy	NN
cord-015021-pol2qm74	5278	21	-	-	HYPH
cord-015021-pol2qm74	5278	22	dependent	dependent	JJ
cord-015021-pol2qm74	5278	23	reduction	reduction	NN
cord-015021-pol2qm74	5278	24	of	of	IN
cord-015021-pol2qm74	5278	25	NAD+	NAD+	NNP
cord-015021-pol2qm74	5278	26	by	by	IN
cord-015021-pol2qm74	5278	27	succinate	succinate	NNP
cord-015021-pol2qm74	5278	28	were	be	VBD
cord-015021-pol2qm74	5278	29	unaltered	unaltered	JJ
cord-015021-pol2qm74	5278	30	by	by	IN
cord-015021-pol2qm74	5278	31	oxidative	oxidative	JJ
cord-015021-pol2qm74	5278	32	stress	stress	NN
cord-015021-pol2qm74	5278	33	.	.	.
cord-015021-pol2qm74	5279	1	Exposure	exposure	NN
cord-015021-pol2qm74	5279	2	to	to	TO
cord-015021-pol2qm74	5279	3	free	free	JJ
cord-015021-pol2qm74	5279	4	radicals	radical	NNS
cord-015021-pol2qm74	5279	5	also	also	RB
cord-015021-pol2qm74	5279	6	had	have	VBD
cord-015021-pol2qm74	5279	7	an	an	DT
cord-015021-pol2qm74	5279	8	uncoupling	uncoupling	JJ
cord-015021-pol2qm74	5279	9	effect	effect	NN
cord-015021-pol2qm74	5279	10	at	at	IN
cord-015021-pol2qm74	5279	11	all	all	RB
cord-015021-pol2qm74	5279	12	three	three	CD
cord-015021-pol2qm74	5279	13	coupling	coupling	NN
cord-015021-pol2qm74	5279	14	sites	site	NNS
cord-015021-pol2qm74	5279	15	.	.	.
cord-015021-pol2qm74	5280	1	The	the	DT
cord-015021-pol2qm74	5280	2	degree	degree	NN
cord-015021-pol2qm74	5280	3	of	of	IN
cord-015021-pol2qm74	5280	4	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5280	5	swelling	swelling	NN
cord-015021-pol2qm74	5280	6	was	be	VBD
cord-015021-pol2qm74	5280	7	closely	closely	RB
cord-015021-pol2qm74	5280	8	correlated	correlate	VBN
cord-015021-pol2qm74	5280	9	with	with	IN
cord-015021-pol2qm74	5280	10	the	the	DT
cord-015021-pol2qm74	5280	11	inhibition	inhibition	NN
cord-015021-pol2qm74	5280	12	of	of	IN
cord-015021-pol2qm74	5280	13	state	state	NN
cord-015021-pol2qm74	5280	14	3	3	CD
cord-015021-pol2qm74	5280	15	oxidation	oxidation	NN
cord-015021-pol2qm74	5280	16	of	of	IN
cord-015021-pol2qm74	5280	17	site	site	NN
cord-015021-pol2qm74	5280	18	I	-PRON-	PRP
cord-015021-pol2qm74	5280	19	substrates	substrate	NNS
cord-015021-pol2qm74	5280	20	and	and	CC
cord-015021-pol2qm74	5280	21	with	with	IN
cord-015021-pol2qm74	5280	22	the	the	DT
cord-015021-pol2qm74	5280	23	increase	increase	NN
cord-015021-pol2qm74	5280	24	in	in	IN
cord-015021-pol2qm74	5280	25	state	state	NN
cord-015021-pol2qm74	5280	26	4	4	CD
cord-015021-pol2qm74	5280	27	oxidation	oxidation	NN
cord-015021-pol2qm74	5280	28	of	of	IN
cord-015021-pol2qm74	5280	29	succinate	succinate	NN
cord-015021-pol2qm74	5280	30	.	.	.
cord-015021-pol2qm74	5281	1	The	the	DT
cord-015021-pol2qm74	5281	2	immunosuppressive	immunosuppressive	JJ
cord-015021-pol2qm74	5281	3	agent	agent	NN
cord-015021-pol2qm74	5281	4	cyclosporin	cyclosporin	NN
cord-015021-pol2qm74	5281	5	A	A	NNP
cord-015021-pol2qm74	5281	6	(	(	-LRB-
cord-015021-pol2qm74	5281	7	CyA	cya	NN
cord-015021-pol2qm74	5281	8	)	)	-RRB-
cord-015021-pol2qm74	5281	9	completely	completely	RB
cord-015021-pol2qm74	5281	10	prevented	prevent	VBD
cord-015021-pol2qm74	5281	11	the	the	DT
cord-015021-pol2qm74	5281	12	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5281	13	damage	damage	NN
cord-015021-pol2qm74	5281	14	induced	induce	VBN
cord-015021-pol2qm74	5281	15	by	by	IN
cord-015021-pol2qm74	5281	16	oxygen	oxygen	NN
cord-015021-pol2qm74	5281	17	free	free	JJ
cord-015021-pol2qm74	5281	18	radicals	radical	NNS
cord-015021-pol2qm74	5281	19	(	(	-LRB-
cord-015021-pol2qm74	5281	20	swelling	swell	VBG
cord-015021-pol2qm74	5281	21	,	,	,
cord-015021-pol2qm74	5281	22	Ca2	Ca2	NNP
cord-015021-pol2qm74	5281	23	+	+	CC
cord-015021-pol2qm74	5281	24	release	release	NN
cord-015021-pol2qm74	5281	25	,	,	,
cord-015021-pol2qm74	5281	26	sucrose	sucrose	NN
cord-015021-pol2qm74	5281	27	trapping	trapping	NN
cord-015021-pol2qm74	5281	28	,	,	,
cord-015021-pol2qm74	5281	29	uncoupling	uncoupling	NN
cord-015021-pol2qm74	5281	30	,	,	,
cord-015021-pol2qm74	5281	31	and	and	CC
cord-015021-pol2qm74	5281	32	selective	selective	JJ
cord-015021-pol2qm74	5281	33	inhibition	inhibition	NN
cord-015021-pol2qm74	5281	34	of	of	IN
cord-015021-pol2qm74	5281	35	the	the	DT
cord-015021-pol2qm74	5281	36	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5281	37	respiration	respiration	NN
cord-015021-pol2qm74	5281	38	of	of	IN
cord-015021-pol2qm74	5281	39	site	site	NN
cord-015021-pol2qm74	5281	40	I	-PRON-	PRP
cord-015021-pol2qm74	5281	41	substrates	substrate	NNS
cord-015021-pol2qm74	5281	42	)	)	-RRB-
cord-015021-pol2qm74	5281	43	.	.	.
cord-015021-pol2qm74	5282	1	The	the	DT
cord-015021-pol2qm74	5282	2	same	same	JJ
cord-015021-pol2qm74	5282	3	protective	protective	JJ
cord-015021-pol2qm74	5282	4	effect	effect	NN
cord-015021-pol2qm74	5282	5	was	be	VBD
cord-015021-pol2qm74	5282	6	found	find	VBN
cord-015021-pol2qm74	5282	7	when	when	WRB
cord-015021-pol2qm74	5282	8	Ca2	Ca2	NNP
cord-015021-pol2qm74	5282	9	+	+	CC
cord-015021-pol2qm74	5282	10	cycling	cycling	NN
cord-015021-pol2qm74	5282	11	was	be	VBD
cord-015021-pol2qm74	5282	12	prevented	prevent	VBN
cord-015021-pol2qm74	5282	13	,	,	,
cord-015021-pol2qm74	5282	14	either	either	CC
cord-015021-pol2qm74	5282	15	by	by	IN
cord-015021-pol2qm74	5282	16	chelating	chelate	VBG
cord-015021-pol2qm74	5282	17	Ca	Ca	NNP
cord-015021-pol2qm74	5282	18	2	2	CD
cord-015021-pol2qm74	5283	1	+	+	CC
cord-015021-pol2qm74	5283	2	with	with	IN
cord-015021-pol2qm74	5283	3	EGTA	EGTA	NNP
cord-015021-pol2qm74	5283	4	or	or	CC
cord-015021-pol2qm74	5283	5	by	by	IN
cord-015021-pol2qm74	5283	6	inhibiting	inhibit	VBG
cord-015021-pol2qm74	5283	7	Ca2	ca2	CD
cord-015021-pol2qm74	5283	8	+	+	CC
cord-015021-pol2qm74	5283	9	re	re	NN
cord-015021-pol2qm74	5283	10	-	-	NN
cord-015021-pol2qm74	5283	11	uptake	uptake	JJ
cord-015021-pol2qm74	5283	12	with	with	IN
cord-015021-pol2qm74	5283	13	ruthenium	ruthenium	JJ
cord-015021-pol2qm74	5283	14	red	red	JJ
cord-015021-pol2qm74	5283	15	.	.	.
cord-015021-pol2qm74	5284	1	These	these	DT
cord-015021-pol2qm74	5284	2	findings	finding	NNS
cord-015021-pol2qm74	5284	3	suggest	suggest	VBP
cord-015021-pol2qm74	5284	4	that	that	IN
cord-015021-pol2qm74	5284	5	the	the	DT
cord-015021-pol2qm74	5284	6	deleterious	deleterious	JJ
cord-015021-pol2qm74	5284	7	effect	effect	NN
cord-015021-pol2qm74	5284	8	of	of	IN
cord-015021-pol2qm74	5284	9	free	free	JJ
cord-015021-pol2qm74	5284	10	radicals	radical	NNS
cord-015021-pol2qm74	5284	11	on	on	IN
cord-015021-pol2qm74	5284	12	mitochondria	mitochondrion	NNS
cord-015021-pol2qm74	5284	13	in	in	IN
cord-015021-pol2qm74	5284	14	the	the	DT
cord-015021-pol2qm74	5284	15	present	present	JJ
cord-015021-pol2qm74	5284	16	experimental	experimental	JJ
cord-015021-pol2qm74	5284	17	system	system	NN
cord-015021-pol2qm74	5284	18	was	be	VBD
cord-015021-pol2qm74	5284	19	triggered	trigger	VBN
cord-015021-pol2qm74	5284	20	by	by	IN
cord-015021-pol2qm74	5284	21	the	the	DT
cord-015021-pol2qm74	5284	22	CyA	cya	NN
cord-015021-pol2qm74	5284	23	-	-	HYPH
cord-015021-pol2qm74	5284	24	sensitive	sensitive	JJ
cord-015021-pol2qm74	5284	25	and	and	CC
cord-015021-pol2qm74	5284	26	Ca2÷-dependent	ca2÷-dependent	JJ
cord-015021-pol2qm74	5284	27	membrane	membrane	NN
cord-015021-pol2qm74	5284	28	transition	transition	NN
cord-015021-pol2qm74	5284	29	,	,	,
cord-015021-pol2qm74	5284	30	and	and	CC
cord-015021-pol2qm74	5284	31	not	not	RB
cord-015021-pol2qm74	5284	32	by	by	IN
cord-015021-pol2qm74	5284	33	direct	direct	JJ
cord-015021-pol2qm74	5284	34	impairment	impairment	NN
cord-015021-pol2qm74	5284	35	of	of	IN
cord-015021-pol2qm74	5284	36	the	the	DT
cord-015021-pol2qm74	5284	37	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5284	38	inner	inner	JJ
cord-015021-pol2qm74	5284	39	membrane	membrane	NN
cord-015021-pol2qm74	5284	40	enzymes	enzyme	NNS
cord-015021-pol2qm74	5284	41	.	.	.
cord-015021-pol2qm74	5285	1	Correspondence	correspondence	NN
cord-015021-pol2qm74	5285	2	should	should	MD
cord-015021-pol2qm74	5285	3	be	be	VB
cord-015021-pol2qm74	5285	4	addressed	address	VBN
cord-015021-pol2qm74	5285	5	to	to	IN
cord-015021-pol2qm74	5285	6	:	:	:
cord-015021-pol2qm74	5285	7	Naoshi	Naoshi	NNP
cord-015021-pol2qm74	5285	8	Takeyama	Takeyama	NNP
cord-015021-pol2qm74	5286	1	The	the	DT
cord-015021-pol2qm74	5286	2	aim	aim	NN
cord-015021-pol2qm74	5286	3	of	of	IN
cord-015021-pol2qm74	5286	4	this	this	DT
cord-015021-pol2qm74	5286	5	study	study	NN
cord-015021-pol2qm74	5286	6	was	be	VBD
cord-015021-pol2qm74	5286	7	to	to	TO
cord-015021-pol2qm74	5286	8	clarify	clarify	VB
cord-015021-pol2qm74	5286	9	the	the	DT
cord-015021-pol2qm74	5286	10	critical	critical	JJ
cord-015021-pol2qm74	5286	11	role	role	NN
cord-015021-pol2qm74	5286	12	of	of	IN
cord-015021-pol2qm74	5286	13	reduced	reduce	VBN
cord-015021-pol2qm74	5286	14	glutathione	glutathione	NN
cord-015021-pol2qm74	5286	15	(	(	-LRB-
cord-015021-pol2qm74	5286	16	GSH	GSH	NNP
cord-015021-pol2qm74	5286	17	)	)	-RRB-
cord-015021-pol2qm74	5286	18	on	on	IN
cord-015021-pol2qm74	5286	19	the	the	DT
cord-015021-pol2qm74	5286	20	progression	progression	NN
cord-015021-pol2qm74	5286	21	of	of	IN
cord-015021-pol2qm74	5286	22	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	5286	23	(	(	-LRB-
cord-015021-pol2qm74	5286	24	LPS)induced	lps)induce	VBN
cord-015021-pol2qm74	5286	25	liver	liver	NN
cord-015021-pol2qm74	5286	26	damage	damage	NN
cord-015021-pol2qm74	5286	27	of	of	IN
cord-015021-pol2qm74	5286	28	mouse	mouse	NN
cord-015021-pol2qm74	5286	29	.	.	.
cord-015021-pol2qm74	5287	1	The	the	DT
cord-015021-pol2qm74	5287	2	conditions	condition	NNS
cord-015021-pol2qm74	5287	3	of	of	IN
cord-015021-pol2qm74	5287	4	GSH	gsh	NN
cord-015021-pol2qm74	5287	5	-	-	HYPH
cord-015021-pol2qm74	5287	6	depletion	depletion	NN
cord-015021-pol2qm74	5287	7	and	and	CC
cord-015021-pol2qm74	5287	8	-richness	-richnes	NNS
cord-015021-pol2qm74	5287	9	were	be	VBD
cord-015021-pol2qm74	5287	10	produced	produce	VBN
cord-015021-pol2qm74	5287	11	by	by	IN
cord-015021-pol2qm74	5287	12	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	5287	13	administration	administration	NN
cord-015021-pol2qm74	5287	14	of	of	IN
cord-015021-pol2qm74	5287	15	buthionine	buthionine	NNP
cord-015021-pol2qm74	5287	16	sulfoximine	sulfoximine	NNP
cord-015021-pol2qm74	5287	17	(	(	-LRB-
cord-015021-pol2qm74	5287	18	BSO	BSO	NNP
cord-015021-pol2qm74	5287	19	)	)	-RRB-
cord-015021-pol2qm74	5287	20	,	,	,
cord-015021-pol2qm74	5287	21	a	a	DT
cord-015021-pol2qm74	5287	22	specific	specific	JJ
cord-015021-pol2qm74	5287	23	inhibitor	inhibitor	NN
cord-015021-pol2qm74	5287	24	of	of	IN
cord-015021-pol2qm74	5287	25	GSH	GSH	NNP
cord-015021-pol2qm74	5287	26	synthetase	synthetase	NN
cord-015021-pol2qm74	5287	27	,	,	,
cord-015021-pol2qm74	5287	28	and	and	CC
cord-015021-pol2qm74	5287	29	of	of	IN
cord-015021-pol2qm74	5287	30	GSH	GSH	NNP
cord-015021-pol2qm74	5287	31	-	-	HYPH
cord-015021-pol2qm74	5287	32	monoethyl	monoethyl	NNP
cord-015021-pol2qm74	5287	33	ester	ester	NN
cord-015021-pol2qm74	5287	34	(	(	-LRB-
cord-015021-pol2qm74	5287	35	GSH	GSH	NNP
cord-015021-pol2qm74	5287	36	-	-	HYPH
cord-015021-pol2qm74	5287	37	ME	ME	NNP
cord-015021-pol2qm74	5287	38	)	)	-RRB-
cord-015021-pol2qm74	5287	39	,	,	,
cord-015021-pol2qm74	5287	40	respectively	respectively	RB
cord-015021-pol2qm74	5287	41	.	.	.
cord-015021-pol2qm74	5288	1	GSH	GSH	NNP
cord-015021-pol2qm74	5288	2	-	-	HYPH
cord-015021-pol2qm74	5288	3	ME	ME	NNP
cord-015021-pol2qm74	5288	4	,	,	,
cord-015021-pol2qm74	5288	5	which	which	WDT
cord-015021-pol2qm74	5288	6	was	be	VBD
cord-015021-pol2qm74	5288	7	esterified	esterify	VBN
cord-015021-pol2qm74	5288	8	the	the	DT
cord-015021-pol2qm74	5288	9	caboxyl	caboxyl	NNP
cord-015021-pol2qm74	5288	10	group	group	NN
cord-015021-pol2qm74	5288	11	of	of	IN
cord-015021-pol2qm74	5288	12	the	the	DT
cord-015021-pol2qm74	5288	13	glycine	glycine	NN
cord-015021-pol2qm74	5288	14	residue	residue	NN
cord-015021-pol2qm74	5288	15	,	,	,
cord-015021-pol2qm74	5288	16	is	be	VBZ
cord-015021-pol2qm74	5288	17	readily	readily	RB
cord-015021-pol2qm74	5288	18	transported	transport	VBN
cord-015021-pol2qm74	5288	19	into	into	IN
cord-015021-pol2qm74	5288	20	cells	cell	NNS
cord-015021-pol2qm74	5288	21	and	and	CC
cord-015021-pol2qm74	5288	22	is	be	VBZ
cord-015021-pol2qm74	5288	23	hydrolyzed	hydrolyze	VBN
cord-015021-pol2qm74	5288	24	intracellularly	intracellularly	RB
cord-015021-pol2qm74	5288	25	;	;	:
cord-015021-pol2qm74	5288	26	this	this	DT
cord-015021-pol2qm74	5288	27	leads	lead	VBZ
cord-015021-pol2qm74	5288	28	to	to	TO
cord-015021-pol2qm74	5288	29	greatly	greatly	RB
cord-015021-pol2qm74	5288	30	increased	increase	VBN
cord-015021-pol2qm74	5288	31	the	the	DT
cord-015021-pol2qm74	5288	32	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	5288	33	and	and	CC
cord-015021-pol2qm74	5288	34	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5288	35	levels	level	NNS
cord-015021-pol2qm74	5288	36	of	of	IN
cord-015021-pol2qm74	5288	37	GSH	GSH	NNP
cord-015021-pol2qm74	5288	38	.	.	.
cord-015021-pol2qm74	5289	1	BSO	BSO	NNP
cord-015021-pol2qm74	5289	2	and	and	CC
cord-015021-pol2qm74	5289	3	GSH	GSH	NNP
cord-015021-pol2qm74	5289	4	-	-	HYPH
cord-015021-pol2qm74	5289	5	ME	ME	NNP
cord-015021-pol2qm74	5289	6	were	be	VBD
cord-015021-pol2qm74	5289	7	administered	administer	VBN
cord-015021-pol2qm74	5289	8	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	5289	9	3	3	CD
cord-015021-pol2qm74	5289	10	mmol	mmol	JJ
cord-015021-pol2qm74	5289	11	/	/	SYM
cord-015021-pol2qm74	5289	12	kg	kg	NNS
cord-015021-pol2qm74	5289	13	and	and	CC
cord-015021-pol2qm74	5289	14	10	10	CD
cord-015021-pol2qm74	5289	15	mmollkg	mmollkg	NN
cord-015021-pol2qm74	5289	16	,	,	,
cord-015021-pol2qm74	5289	17	respectively	respectively	RB
cord-015021-pol2qm74	5289	18	,	,	,
cord-015021-pol2qm74	5289	19	and	and	CC
cord-015021-pol2qm74	5289	20	LPS	LPS	NNP
cord-015021-pol2qm74	5289	21	(	(	-LRB-
cord-015021-pol2qm74	5289	22	2	2	CD
cord-015021-pol2qm74	5289	23	mg	mg	NNP
cord-015021-pol2qm74	5289	24	/	/	SYM
cord-015021-pol2qm74	5289	25	kg	kg	NNP
cord-015021-pol2qm74	5289	26	)	)	-RRB-
cord-015021-pol2qm74	5289	27	given	give	VBN
cord-015021-pol2qm74	5289	28	1	1	CD
cord-015021-pol2qm74	5289	29	h	h	NN
cord-015021-pol2qm74	5289	30	later	later	RB
cord-015021-pol2qm74	5289	31	.	.	.
cord-015021-pol2qm74	5290	1	Hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5290	2	were	be	VBD
cord-015021-pol2qm74	5290	3	isolated	isolate	VBN
cord-015021-pol2qm74	5290	4	by	by	IN
cord-015021-pol2qm74	5290	5	in	in	IN
cord-015021-pol2qm74	5290	6	situ	situ	JJ
cord-015021-pol2qm74	5290	7	perfusion	perfusion	NN
cord-015021-pol2qm74	5290	8	of	of	IN
cord-015021-pol2qm74	5290	9	the	the	DT
cord-015021-pol2qm74	5290	10	liver	liver	NN
cord-015021-pol2qm74	5290	11	with	with	IN
cord-015021-pol2qm74	5290	12	collagenase	collagenase	NNP
cord-015021-pol2qm74	5290	13	6	6	CD
cord-015021-pol2qm74	5290	14	h	h	NNP
cord-015021-pol2qm74	5290	15	after	after	IN
cord-015021-pol2qm74	5290	16	LPS	LPS	NNP
cord-015021-pol2qm74	5290	17	injection	injection	NN
cord-015021-pol2qm74	5290	18	.	.	.
cord-015021-pol2qm74	5291	1	The	the	DT
cord-015021-pol2qm74	5291	2	degree	degree	NN
cord-015021-pol2qm74	5291	3	of	of	IN
cord-015021-pol2qm74	5291	4	hydrogen	hydrogen	NN
cord-015021-pol2qm74	5291	5	peroxide	peroxide	NN
cord-015021-pol2qm74	5291	6	(	(	-LRB-
cord-015021-pol2qm74	5291	7	H202	H202	NNP
cord-015021-pol2qm74	5291	8	)	)	-RRB-
cord-015021-pol2qm74	5291	9	synthesis	synthesis	NN
cord-015021-pol2qm74	5291	10	and	and	CC
cord-015021-pol2qm74	5291	11	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5291	12	membrane	membrane	NN
cord-015021-pol2qm74	5291	13	potential	potential	NN
cord-015021-pol2qm74	5291	14	were	be	VBD
cord-015021-pol2qm74	5291	15	measured	measure	VBN
cord-015021-pol2qm74	5291	16	by	by	IN
cord-015021-pol2qm74	5291	17	flow	flow	NN
cord-015021-pol2qm74	5291	18	cytometry	cytometry	NN
cord-015021-pol2qm74	5291	19	using	use	VBG
cord-015021-pol2qm74	5291	20	fluorescence	fluorescence	NN
cord-015021-pol2qm74	5291	21	probe	probe	NN
cord-015021-pol2qm74	5291	22	dichrolofluorescein	dichrolofluorescein	NNP
cord-015021-pol2qm74	5291	23	diacetate	diacetate	NNP
cord-015021-pol2qm74	5291	24	and	and	CC
cord-015021-pol2qm74	5291	25	tetrametyl	tetrametyl	NNP
cord-015021-pol2qm74	5291	26	rhodamine	rhodamine	NNP
cord-015021-pol2qm74	5291	27	ethyl	ethyl	NNP
cord-015021-pol2qm74	5291	28	ester	ester	NN
cord-015021-pol2qm74	5291	29	,	,	,
cord-015021-pol2qm74	5291	30	respectively	respectively	RB
cord-015021-pol2qm74	5291	31	.	.	.
cord-015021-pol2qm74	5292	1	The	the	DT
cord-015021-pol2qm74	5292	2	degree	degree	NN
cord-015021-pol2qm74	5292	3	of	of	IN
cord-015021-pol2qm74	5292	4	mitochondria	mitochondrion	NNS
cord-015021-pol2qm74	5292	5	membrane	membrane	NN
cord-015021-pol2qm74	5292	6	permeability	permeability	NN
cord-015021-pol2qm74	5292	7	transition	transition	NN
cord-015021-pol2qm74	5292	8	(	(	-LRB-
cord-015021-pol2qm74	5292	9	MMP	MMP	NNP
cord-015021-pol2qm74	5292	10	)	)	-RRB-
cord-015021-pol2qm74	5292	11	was	be	VBD
cord-015021-pol2qm74	5292	12	assessed	assess	VBN
cord-015021-pol2qm74	5292	13	by	by	IN
cord-015021-pol2qm74	5292	14	[	[	-LRB-
cord-015021-pol2qm74	5292	15	014]sucrose	014]sucrose	CD
cord-015021-pol2qm74	5292	16	entrapment	entrapment	NN
cord-015021-pol2qm74	5292	17	.	.	.
cord-015021-pol2qm74	5293	1	We	-PRON-	PRP
cord-015021-pol2qm74	5293	2	found	find	VBD
cord-015021-pol2qm74	5293	3	that	that	IN
cord-015021-pol2qm74	5293	4	LPS	LPS	NNP
cord-015021-pol2qm74	5293	5	treatment	treatment	NN
cord-015021-pol2qm74	5293	6	results	result	NNS
cord-015021-pol2qm74	5293	7	in	in	IN
cord-015021-pol2qm74	5293	8	a	a	DT
cord-015021-pol2qm74	5293	9	decrease	decrease	NN
cord-015021-pol2qm74	5293	10	in	in	IN
cord-015021-pol2qm74	5293	11	hepatic	hepatic	JJ
cord-015021-pol2qm74	5293	12	GSH	GSH	NNP
cord-015021-pol2qm74	5293	13	level	level	NN
cord-015021-pol2qm74	5293	14	and	and	CC
cord-015021-pol2qm74	5293	15	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5293	16	membrane	membrane	NN
cord-015021-pol2qm74	5293	17	potential	potential	NN
cord-015021-pol2qm74	5293	18	,	,	,
cord-015021-pol2qm74	5293	19	and	and	CC
cord-015021-pol2qm74	5293	20	an	an	DT
cord-015021-pol2qm74	5293	21	increase	increase	NN
cord-015021-pol2qm74	5293	22	in	in	IN
cord-015021-pol2qm74	5293	23	H202	h202	NN
cord-015021-pol2qm74	5293	24	synthesis	synthesis	NN
cord-015021-pol2qm74	5293	25	and	and	CC
cord-015021-pol2qm74	5293	26	MMP	MMP	NNP
cord-015021-pol2qm74	5293	27	.	.	.
cord-015021-pol2qm74	5294	1	LPS	LPS	NNP
cord-015021-pol2qm74	5294	2	administration	administration	NN
cord-015021-pol2qm74	5294	3	to	to	IN
cord-015021-pol2qm74	5294	4	BSQ	bsq	NN
cord-015021-pol2qm74	5294	5	-	-	HYPH
cord-015021-pol2qm74	5294	6	pretreated	pretreate	VBN
cord-015021-pol2qm74	5294	7	mouse	mouse	NN
cord-015021-pol2qm74	5294	8	worsened	worsen	VBD
cord-015021-pol2qm74	5294	9	at	at	IN
cord-015021-pol2qm74	5294	10	[	[	-LRB-
cord-015021-pol2qm74	5294	11	these	these	DT
cord-015021-pol2qm74	5294	12	parameters	parameter	NNS
cord-015021-pol2qm74	5294	13	.	.	.
cord-015021-pol2qm74	5295	1	In	in	IN
cord-015021-pol2qm74	5295	2	contrast	contrast	NN
cord-015021-pol2qm74	5295	3	,	,	,
cord-015021-pol2qm74	5295	4	GSH	GSH	NNP
cord-015021-pol2qm74	5295	5	-	-	HYPH
cord-015021-pol2qm74	5295	6	ME	ME	NNP
cord-015021-pol2qm74	5295	7	pretreatment	pretreatment	NN
cord-015021-pol2qm74	5295	8	ameliorates	ameliorate	VBZ
cord-015021-pol2qm74	5295	9	.	.	.
cord-015021-pol2qm74	5296	1	All	all	RB
cord-015021-pol2qm74	5296	2	together	together	RB
cord-015021-pol2qm74	5296	3	,	,	,
cord-015021-pol2qm74	5296	4	GSH	GSH	NNP
cord-015021-pol2qm74	5296	5	may	may	MD
cord-015021-pol2qm74	5296	6	acts	act	VBZ
cord-015021-pol2qm74	5296	7	an	an	DT
cord-015021-pol2qm74	5296	8	important	important	JJ
cord-015021-pol2qm74	5296	9	role	role	NN
cord-015021-pol2qm74	5296	10	in	in	IN
cord-015021-pol2qm74	5296	11	cellular	cellular	JJ
cord-015021-pol2qm74	5296	12	defence	defence	NN
cord-015021-pol2qm74	5296	13	against	against	IN
cord-015021-pol2qm74	5296	14	LPS	LPS	NNP
cord-015021-pol2qm74	5296	15	-	-	HYPH
cord-015021-pol2qm74	5296	16	mediated	mediate	VBN
cord-015021-pol2qm74	5296	17	liver	liver	NN
cord-015021-pol2qm74	5296	18	damage	damage	NN
cord-015021-pol2qm74	5296	19	,	,	,
cord-015021-pol2qm74	5296	20	and	and	CC
cord-015021-pol2qm74	5296	21	MMP	MMP	NNP
cord-015021-pol2qm74	5296	22	may	may	MD
cord-015021-pol2qm74	5296	23	result	result	VB
cord-015021-pol2qm74	5296	24	in	in	IN
cord-015021-pol2qm74	5296	25	the	the	DT
cord-015021-pol2qm74	5296	26	decrease	decrease	NN
cord-015021-pol2qm74	5296	27	in	in	IN
cord-015021-pol2qm74	5296	28	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	5296	29	membrane	membrane	NN
cord-015021-pol2qm74	5296	30	potential	potential	NN
cord-015021-pol2qm74	5296	31	.	.	.
cord-015021-pol2qm74	5297	1	It	-PRON-	PRP
cord-015021-pol2qm74	5297	2	has	have	VBZ
cord-015021-pol2qm74	5297	3	been	be	VBN
cord-015021-pol2qm74	5297	4	shown	show	VBN
cord-015021-pol2qm74	5297	5	,	,	,
cord-015021-pol2qm74	5297	6	up	up	IN
cord-015021-pol2qm74	5297	7	to	to	IN
cord-015021-pol2qm74	5297	8	now	now	RB
cord-015021-pol2qm74	5297	9	,	,	,
cord-015021-pol2qm74	5297	10	that	that	IN
cord-015021-pol2qm74	5297	11	disturbances	disturbance	NNS
cord-015021-pol2qm74	5297	12	of	of	IN
cord-015021-pol2qm74	5297	13	enzymatic	enzymatic	JJ
cord-015021-pol2qm74	5297	14	processes	process	NNS
cord-015021-pol2qm74	5297	15	in	in	IN
cord-015021-pol2qm74	5297	16	the	the	DT
cord-015021-pol2qm74	5297	17	cell	cell	NN
cord-015021-pol2qm74	5297	18	organella	organella	NN
cord-015021-pol2qm74	5297	19	are	be	VBP
cord-015021-pol2qm74	5297	20	the	the	DT
cord-015021-pol2qm74	5297	21	basic	basic	JJ
cord-015021-pol2qm74	5297	22	factor	factor	NN
cord-015021-pol2qm74	5297	23	of	of	IN
cord-015021-pol2qm74	5297	24	the	the	DT
cord-015021-pol2qm74	5297	25	changes	change	NNS
cord-015021-pol2qm74	5297	26	taking	take	VBG
cord-015021-pol2qm74	5297	27	place	place	NN
cord-015021-pol2qm74	5297	28	during	during	IN
cord-015021-pol2qm74	5297	29	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5297	30	shock	shock	NN
cord-015021-pol2qm74	5298	1	It	-PRON-	PRP
cord-015021-pol2qm74	5298	2	has	have	VBZ
cord-015021-pol2qm74	5298	3	been	be	VBN
cord-015021-pol2qm74	5298	4	observed	observe	VBN
cord-015021-pol2qm74	5298	5	that	that	IN
cord-015021-pol2qm74	5298	6	lysosomes	lysosome	NNS
cord-015021-pol2qm74	5298	7	are	be	VBP
cord-015021-pol2qm74	5298	8	biochemically	biochemically	RB
cord-015021-pol2qm74	5298	9	changed	change	VBN
cord-015021-pol2qm74	5298	10	as	as	IN
cord-015021-pol2qm74	5298	11	result	result	NN
cord-015021-pol2qm74	5298	12	of	of	IN
cord-015021-pol2qm74	5298	13	the	the	DT
cord-015021-pol2qm74	5298	14	effect	effect	NN
cord-015021-pol2qm74	5298	15	of	of	IN
cord-015021-pol2qm74	5298	16	lipopotysacharides	lipopotysacharide	NNS
cord-015021-pol2qm74	5298	17	of	of	IN
cord-015021-pol2qm74	5298	18	gram	gram	NN
cord-015021-pol2qm74	5298	19	negative	negative	JJ
cord-015021-pol2qm74	5298	20	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	5298	21	bacteria	bacteria	NNS
cord-015021-pol2qm74	5298	22	.	.	.
cord-015021-pol2qm74	5299	1	The	the	DT
cord-015021-pol2qm74	5299	2	purpose	purpose	NN
cord-015021-pol2qm74	5299	3	of	of	IN
cord-015021-pol2qm74	5299	4	the	the	DT
cord-015021-pol2qm74	5299	5	experiment	experiment	NN
cord-015021-pol2qm74	5299	6	was	be	VBD
cord-015021-pol2qm74	5299	7	:	:	:
cord-015021-pol2qm74	5299	8	1.evaluation	1.evaluation	CD
cord-015021-pol2qm74	5299	9	nfthe	nfthe	NNP
cord-015021-pol2qm74	5299	10	course	course	NN
cord-015021-pol2qm74	5299	11	of	of	IN
cord-015021-pol2qm74	5299	12	the	the	DT
cord-015021-pol2qm74	5299	13	EES	EES	NNP
cord-015021-pol2qm74	5299	14	due	due	IN
cord-015021-pol2qm74	5299	15	to	to	IN
cord-015021-pol2qm74	5299	16	the	the	DT
cord-015021-pol2qm74	5299	17	biochemic	biochemic	JJ
cord-015021-pol2qm74	5299	18	changes	change	VBZ
cord-015021-pol2qm74	5299	19	2.determination	2.determination	CD
cord-015021-pol2qm74	5299	20	of	of	IN
cord-015021-pol2qm74	5299	21	the	the	DT
cord-015021-pol2qm74	5299	22	influence	influence	NN
cord-015021-pol2qm74	5299	23	of	of	IN
cord-015021-pol2qm74	5299	24	the	the	DT
cord-015021-pol2qm74	5299	25	EES	EES	NNP
cord-015021-pol2qm74	5299	26	on	on	IN
cord-015021-pol2qm74	5299	27	the	the	DT
cord-015021-pol2qm74	5299	28	activity	activity	NN
cord-015021-pol2qm74	5299	29	of	of	IN
cord-015021-pol2qm74	5299	30	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	5299	31	enzymes	enzyme	NNS
cord-015021-pol2qm74	5299	32	in	in	IN
cord-015021-pol2qm74	5299	33	liver	liver	NN
cord-015021-pol2qm74	5299	34	cell	cell	NN
cord-015021-pol2qm74	5299	35	3.deterrmnatian	3.deterrmnatian	CD
cord-015021-pol2qm74	5299	36	of	of	IN
cord-015021-pol2qm74	5299	37	the	the	DT
cord-015021-pol2qm74	5299	38	influence	influence	NN
cord-015021-pol2qm74	5299	39	of	of	IN
cord-015021-pol2qm74	5299	40	H	h	NN
cord-015021-pol2qm74	5299	41	and	and	CC
cord-015021-pol2qm74	5299	42	D	d	NN
cord-015021-pol2qm74	5299	43	on	on	IN
cord-015021-pol2qm74	5299	44	the	the	DT
cord-015021-pol2qm74	5299	45	activity	activity	NN
cord-015021-pol2qm74	5299	46	of	of	IN
cord-015021-pol2qm74	5299	47	some	some	DT
cord-015021-pol2qm74	5299	48	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	5299	49	enzymes	enzyme	NNS
cord-015021-pol2qm74	5299	50	in	in	IN
cord-015021-pol2qm74	5299	51	liver	liver	NN
cord-015021-pol2qm74	5299	52	cell	cell	NN
cord-015021-pol2qm74	5299	53	during	during	IN
cord-015021-pol2qm74	5299	54	EES	EES	NNP
cord-015021-pol2qm74	5299	55	Material	Material	NNP
cord-015021-pol2qm74	5299	56	and	and	CC
cord-015021-pol2qm74	5299	57	method	method	NN
cord-015021-pol2qm74	5299	58	:	:	:
cord-015021-pol2qm74	5300	1	Examinations	examination	NNS
cord-015021-pol2qm74	5300	2	ware	ware	NNP
cord-015021-pol2qm74	5300	3	carried	carry	VBD
cord-015021-pol2qm74	5300	4	out	out	RP
cord-015021-pol2qm74	5300	5	on	on	IN
cord-015021-pol2qm74	5300	6	30	30	CD
cord-015021-pol2qm74	5300	7	dogs	dog	NNS
cord-015021-pol2qm74	5300	8	.	.	.
cord-015021-pol2qm74	5301	1	The	the	DT
cord-015021-pol2qm74	5301	2	shock	shock	NN
cord-015021-pol2qm74	5301	3	was	be	VBD
cord-015021-pol2qm74	5301	4	evoked	evoke	VBN
cord-015021-pol2qm74	5301	5	by	by	IN
cord-015021-pol2qm74	5301	6	i.v	i.v	NNP
cord-015021-pol2qm74	5301	7	.	.	NNP
cord-015021-pol2qm74	5301	8	administration	administration	NN
cord-015021-pol2qm74	5301	9	of	of	IN
cord-015021-pol2qm74	5301	10	endotoxin	endotoxin	NNP
cord-015021-pol2qm74	5301	11	E.coli	E.coli	NNP
cord-015021-pol2qm74	5301	12	.	.	.
cord-015021-pol2qm74	5302	1	The	the	DT
cord-015021-pol2qm74	5302	2	dogs	dog	NNS
cord-015021-pol2qm74	5302	3	were	be	VBD
cord-015021-pol2qm74	5302	4	divided	divide	VBN
cord-015021-pol2qm74	5302	5	into	into	IN
cord-015021-pol2qm74	5302	6	5	5	CD
cord-015021-pol2qm74	5302	7	groups	group	NNS
cord-015021-pol2qm74	5302	8	:	:	:
cord-015021-pol2qm74	5303	1	Icontrols	Icontrols	NNP
cord-015021-pol2qm74	5303	2	,	,	,
cord-015021-pol2qm74	5303	3	I	-PRON-	PRP
cord-015021-pol2qm74	5303	4	[	[	-LRB-
cord-015021-pol2qm74	5303	5	-dogs	-dog	NNS
cord-015021-pol2qm74	5303	6	with	with	IN
cord-015021-pol2qm74	5303	7	untreated	untreated	JJ
cord-015021-pol2qm74	5303	8	shock	shock	NN
cord-015021-pol2qm74	5303	9	,	,	,
cord-015021-pol2qm74	5303	10	III	III	NNP
cord-015021-pol2qm74	5303	11	-	-	HYPH
cord-015021-pol2qm74	5303	12	dogs	dog	NNS
cord-015021-pol2qm74	5303	13	in	in	IN
cord-015021-pol2qm74	5303	14	shock	shock	NN
cord-015021-pol2qm74	5303	15	treated	treat	VBN
cord-015021-pol2qm74	5303	16	with	with	IN
cord-015021-pol2qm74	5303	17	H	H	NNP
cord-015021-pol2qm74	5303	18	,	,	,
cord-015021-pol2qm74	5303	19	IVdogs	IVdogs	NNP
cord-015021-pol2qm74	5303	20	in	in	IN
cord-015021-pol2qm74	5303	21	shock	shock	NN
cord-015021-pol2qm74	5303	22	treated	treat	VBN
cord-015021-pol2qm74	5303	23	with	with	IN
cord-015021-pol2qm74	5303	24	D	D	NNP
cord-015021-pol2qm74	5303	25	,	,	,
cord-015021-pol2qm74	5303	26	V	v	NN
cord-015021-pol2qm74	5303	27	-dogs	-dogs	NN
cord-015021-pol2qm74	5304	1	in	in	IN
cord-015021-pol2qm74	5304	2	shock	shock	NN
cord-015021-pol2qm74	5304	3	treated	treat	VBN
cord-015021-pol2qm74	5304	4	with	with	IN
cord-015021-pol2qm74	5304	5	H	H	NNP
cord-015021-pol2qm74	5304	6	and	and	CC
cord-015021-pol2qm74	5304	7	D.	D.	NNP
cord-015021-pol2qm74	5305	1	The	the	DT
cord-015021-pol2qm74	5305	2	following	following	JJ
cord-015021-pol2qm74	5305	3	parameters	parameter	NNS
cord-015021-pol2qm74	5305	4	were	be	VBD
cord-015021-pol2qm74	5305	5	determined	determine	VBN
cord-015021-pol2qm74	5305	6	:	:	:
cord-015021-pol2qm74	5305	7	1.Activity	1.activity	CD
cord-015021-pol2qm74	5305	8	of	of	IN
cord-015021-pol2qm74	5305	9	acid	acid	NN
cord-015021-pol2qm74	5305	10	phosphatase	phosphatase	NN
cord-015021-pol2qm74	5305	11	in	in	IN
cord-015021-pol2qm74	5305	12	the	the	DT
cord-015021-pol2qm74	5305	13	venous	venous	JJ
cord-015021-pol2qm74	5305	14	blood	blood	NN
cord-015021-pol2qm74	5305	15	serum	serum	NN
cord-015021-pol2qm74	5305	16	.	.	.
cord-015021-pol2qm74	5306	1	2	2	LS
cord-015021-pol2qm74	5306	2	-	-	SYM
cord-015021-pol2qm74	5306	3	6.Total	6.total	CD
cord-015021-pol2qm74	5306	4	and	and	CC
cord-015021-pol2qm74	5306	5	free	free	JJ
cord-015021-pol2qm74	5306	6	activity	activity	NN
cord-015021-pol2qm74	5306	7	of	of	IN
cord-015021-pol2qm74	5306	8	acid	acid	NN
cord-015021-pol2qm74	5306	9	phosphatase	phosphatase	NN
cord-015021-pol2qm74	5306	10	and	and	CC
cord-015021-pol2qm74	5306	11	catepsins	catepsin	NNS
cord-015021-pol2qm74	5306	12	in	in	IN
cord-015021-pol2qm74	5306	13	the	the	DT
cord-015021-pol2qm74	5306	14	full	full	JJ
cord-015021-pol2qm74	5306	15	liver	liver	NN
cord-015021-pol2qm74	5306	16	cell	cell	NN
cord-015021-pol2qm74	5306	17	homogenate	homogenate	NNP
cord-015021-pol2qm74	5306	18	,	,	,
cord-015021-pol2qm74	5306	19	in	in	IN
cord-015021-pol2qm74	5306	20	mitochondrial	mitochondrial	NN
cord-015021-pol2qm74	5306	21	-	-	HYPH
cord-015021-pol2qm74	5306	22	and	and	CC
cord-015021-pol2qm74	5306	23	-	-	HYPH
cord-015021-pol2qm74	5306	24	lysosomal	lysosomal	NN
cord-015021-pol2qm74	5306	25	fraction	fraction	NN
cord-015021-pol2qm74	5306	26	,	,	,
cord-015021-pol2qm74	5306	27	and	and	CC
cord-015021-pol2qm74	5306	28	in	in	IN
cord-015021-pol2qm74	5306	29	the	the	DT
cord-015021-pol2qm74	5306	30	superuatunt	superuatunt	NN
cord-015021-pol2qm74	5306	31	(	(	-LRB-
cord-015021-pol2qm74	5306	32	all	all	RB
cord-015021-pol2qm74	5306	33	after	after	IN
cord-015021-pol2qm74	5306	34	4	4	CD
cord-015021-pol2qm74	5306	35	hours	hour	NNS
cord-015021-pol2qm74	5306	36	of	of	IN
cord-015021-pol2qm74	5306	37	the	the	DT
cord-015021-pol2qm74	5306	38	experiment	experiment	NN
cord-015021-pol2qm74	5306	39	)	)	-RRB-
cord-015021-pol2qm74	5306	40	.	.	.
cord-015021-pol2qm74	5307	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	5307	2	1	1	CD
cord-015021-pol2qm74	5307	3	.	.	.
cord-015021-pol2qm74	5308	1	Essential	essential	JJ
cord-015021-pol2qm74	5308	2	increase	increase	NN
cord-015021-pol2qm74	5308	3	of	of	IN
cord-015021-pol2qm74	5308	4	activity	activity	NN
cord-015021-pol2qm74	5308	5	of	of	IN
cord-015021-pol2qm74	5308	6	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	5308	7	enzymes	enzyme	NNS
cord-015021-pol2qm74	5308	8	was	be	VBD
cord-015021-pol2qm74	5308	9	observed	observe	VBN
cord-015021-pol2qm74	5308	10	in	in	IN
cord-015021-pol2qm74	5308	11	the	the	DT
cord-015021-pol2qm74	5308	12	EES	EES	NNP
cord-015021-pol2qm74	5308	13	.	.	.
cord-015021-pol2qm74	5309	1	2	2	LS
cord-015021-pol2qm74	5309	2	.	.	.
cord-015021-pol2qm74	5310	1	Increased	increase	VBN
cord-015021-pol2qm74	5310	2	activity	activity	NN
cord-015021-pol2qm74	5310	3	of	of	IN
cord-015021-pol2qm74	5310	4	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	5310	5	hydrolases	hydrolase	NNS
cord-015021-pol2qm74	5310	6	in	in	IN
cord-015021-pol2qm74	5310	7	the	the	DT
cord-015021-pol2qm74	5310	8	liver	liver	NN
cord-015021-pol2qm74	5310	9	cell	cell	NN
cord-015021-pol2qm74	5310	10	homogenate	homogenate	NNP
cord-015021-pol2qm74	5310	11	corresponds	correspond	VBZ
cord-015021-pol2qm74	5310	12	,	,	,
cord-015021-pol2qm74	5310	13	as	as	IN
cord-015021-pol2qm74	5310	14	a	a	DT
cord-015021-pol2qm74	5310	15	result	result	NN
cord-015021-pol2qm74	5310	16	of	of	IN
cord-015021-pol2qm74	5310	17	the	the	DT
cord-015021-pol2qm74	5310	18	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5310	19	effect	effect	NN
cord-015021-pol2qm74	5310	20	,	,	,
cord-015021-pol2qm74	5310	21	with	with	IN
cord-015021-pol2qm74	5310	22	increased	increase	VBN
cord-015021-pol2qm74	5310	23	enzymatic	enzymatic	JJ
cord-015021-pol2qm74	5310	24	activity	activity	NN
cord-015021-pol2qm74	5310	25	in	in	IN
cord-015021-pol2qm74	5310	26	the	the	DT
cord-015021-pol2qm74	5310	27	peripherial	peripherial	JJ
cord-015021-pol2qm74	5310	28	blood	blood	NN
cord-015021-pol2qm74	5310	29	.	.	.
cord-015021-pol2qm74	5311	1	Extensive	extensive	JJ
cord-015021-pol2qm74	5311	2	investigations	investigation	NNS
cord-015021-pol2qm74	5311	3	from	from	IN
cord-015021-pol2qm74	5311	4	our	-PRON-	PRP$
cord-015021-pol2qm74	5311	5	laboratory	laboratory	NN
cord-015021-pol2qm74	5311	6	of	of	IN
cord-015021-pol2qm74	5311	7	the	the	DT
cord-015021-pol2qm74	5311	8	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	5311	9	of	of	IN
cord-015021-pol2qm74	5311	10	hepatic	hepatic	JJ
cord-015021-pol2qm74	5311	11	no	no	DT
cord-015021-pol2qm74	5311	12	-	-	HYPH
cord-015021-pol2qm74	5311	13	flow	flow	NN
cord-015021-pol2qm74	5311	14	ischemia	ischemia	NN
cord-015021-pol2qm74	5311	15	(	(	-LRB-
cord-015021-pol2qm74	5311	16	45	45	CD
cord-015021-pol2qm74	5311	17	min	min	NN
cord-015021-pol2qm74	5311	18	)	)	-RRB-
cord-015021-pol2qm74	5312	1	-reperfusion	-reperfusion	:
cord-015021-pol2qm74	5312	2	injury	injury	NN
cord-015021-pol2qm74	5312	3	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	5312	4	substantial	substantial	JJ
cord-015021-pol2qm74	5312	5	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5312	6	cell	cell	NN
cord-015021-pol2qm74	5312	7	activation	activation	NN
cord-015021-pol2qm74	5312	8	with	with	IN
cord-015021-pol2qm74	5312	9	reactive	reactive	JJ
cord-015021-pol2qm74	5312	10	oxygen	oxygen	NN
cord-015021-pol2qm74	5312	11	formation	formation	NN
cord-015021-pol2qm74	5312	12	during	during	IN
cord-015021-pol2qm74	5312	13	the	the	DT
cord-015021-pol2qm74	5312	14	first	first	JJ
cord-015021-pol2qm74	5312	15	few	few	JJ
cord-015021-pol2qm74	5312	16	hours	hour	NNS
cord-015021-pol2qm74	5312	17	of	of	IN
cord-015021-pol2qm74	5312	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5312	19	as	as	IN
cord-015021-pol2qm74	5312	20	indicated	indicate	VBN
cord-015021-pol2qm74	5312	21	by	by	IN
cord-015021-pol2qm74	5312	22	increases	increase	NNS
cord-015021-pol2qm74	5312	23	in	in	IN
cord-015021-pol2qm74	5312	24	plasma	plasma	NN
cord-015021-pol2qm74	5312	25	glutathione	glutathione	NN
cord-015021-pol2qm74	5312	26	disulfide	disulfide	NN
cord-015021-pol2qm74	5313	1	(	(	-LRB-
cord-015021-pol2qm74	5313	2	GSSG	GSSG	NNP
cord-015021-pol2qm74	5313	3	)	)	-RRB-
cord-015021-pol2qm74	5313	4	levels	level	NNS
cord-015021-pol2qm74	5313	5	in	in	IN
cord-015021-pol2qm74	5313	6	vivo	vivo	NN
cord-015021-pol2qm74	5313	7	(	(	-LRB-
cord-015021-pol2qm74	5313	8	Am	Am	NNP
cord-015021-pol2qm74	5313	9	.	.	.
cord-015021-pol2qm74	5314	1	J.	J.	NNP
cord-015021-pol2qm74	5314	2	Physiol	Physiol	NNP
cord-015021-pol2qm74	5314	3	.	.	.
cord-015021-pol2qm74	5314	4	260	260	CD
cord-015021-pol2qm74	5314	5	:	:	:
cord-015021-pol2qm74	5314	6	G355	g355	CD
cord-015021-pol2qm74	5314	7	,	,	,
cord-015021-pol2qm74	5314	8	1991	1991	CD
cord-015021-pol2qm74	5314	9	)	)	-RRB-
cord-015021-pol2qm74	5314	10	and	and	CC
cord-015021-pol2qm74	5314	11	enhanced	enhanced	JJ
cord-015021-pol2qm74	5314	12	superoxide	superoxide	NN
cord-015021-pol2qm74	5314	13	formation	formation	NN
cord-015021-pol2qm74	5314	14	by	by	IN
cord-015021-pol2qm74	5314	15	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5314	16	cells	cell	NNS
cord-015021-pol2qm74	5314	17	(	(	-LRB-
cord-015021-pol2qm74	5314	18	KC	KC	NNP
cord-015021-pol2qm74	5314	19	)	)	-RRB-
cord-015021-pol2qm74	5314	20	isolated	isolate	VBN
cord-015021-pol2qm74	5314	21	from	from	IN
cord-015021-pol2qm74	5314	22	the	the	DT
cord-015021-pol2qm74	5314	23	postischemic	postischemic	JJ
cord-015021-pol2qm74	5314	24	livers	liver	NNS
cord-015021-pol2qm74	5314	25	(	(	-LRB-
cord-015021-pol2qm74	5314	26	Free	Free	NNP
cord-015021-pol2qm74	5314	27	Radic	Radic	NNP
cord-015021-pol2qm74	5314	28	.	.	.
cord-015021-pol2qm74	5315	1	Res	Res	NNP
cord-015021-pol2qm74	5315	2	.	.	NNP
cord-015021-pol2qm74	5315	3	Commun	Commun	NNP
cord-015021-pol2qm74	5315	4	.	.	.
cord-015021-pol2qm74	5316	1	15:277	15:277	CD
cord-015021-pol2qm74	5316	2	,	,	,
cord-015021-pol2qm74	5316	3	1991	1991	CD
cord-015021-pol2qm74	5316	4	)	)	-RRB-
cord-015021-pol2qm74	5316	5	.	.	.
cord-015021-pol2qm74	5317	1	The	the	DT
cord-015021-pol2qm74	5317	2	early	early	JJ
cord-015021-pol2qm74	5317	3	KC	KC	NNP
cord-015021-pol2qm74	5317	4	-	-	HYPH
cord-015021-pol2qm74	5317	5	induced	induce	VBN
cord-015021-pol2qm74	5317	6	injury	injury	NN
cord-015021-pol2qm74	5317	7	initiated	initiate	VBD
cord-015021-pol2qm74	5317	8	the	the	DT
cord-015021-pol2qm74	5317	9	later	later	RBR
cord-015021-pol2qm74	5317	10	,	,	,
cord-015021-pol2qm74	5317	11	primarily	primarily	RB
cord-015021-pol2qm74	5317	12	neutrophilmediated	neutrophilmediate	VBD
cord-015021-pol2qm74	5317	13	reperfusion	reperfusion	NN
cord-015021-pol2qm74	5317	14	injury	injury	NN
cord-015021-pol2qm74	5317	15	(	(	-LRB-
cord-015021-pol2qm74	5317	16	FASEB	FASEB	NNP
cord-015021-pol2qm74	5317	17	J.	J.	NNP
cord-015021-pol2qm74	5317	18	4	4	CD
cord-015021-pol2qm74	5317	19	:	:	:
cord-015021-pol2qm74	5317	20	3355	3355	CD
cord-015021-pol2qm74	5317	21	,	,	,
cord-015021-pol2qm74	5317	22	1990	1990	CD
cord-015021-pol2qm74	5317	23	)	)	-RRB-
cord-015021-pol2qm74	5317	24	.	.	.
cord-015021-pol2qm74	5318	1	To	to	TO
cord-015021-pol2qm74	5318	2	test	test	VB
cord-015021-pol2qm74	5318	3	whether	whether	IN
cord-015021-pol2qm74	5318	4	or	or	CC
cord-015021-pol2qm74	5318	5	not	not	RB
cord-015021-pol2qm74	5318	6	similar	similar	JJ
cord-015021-pol2qm74	5318	7	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5318	8	are	be	VBP
cord-015021-pol2qm74	5318	9	operative	operative	JJ
cord-015021-pol2qm74	5318	10	during	during	IN
cord-015021-pol2qm74	5318	11	hepatic	hepatic	JJ
cord-015021-pol2qm74	5318	12	ischemia	ischemia	NN
cord-015021-pol2qm74	5318	13	induced	induce	VBN
cord-015021-pol2qm74	5318	14	by	by	IN
cord-015021-pol2qm74	5318	15	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5318	16	shock	shock	NN
cord-015021-pol2qm74	5318	17	,	,	,
cord-015021-pol2qm74	5318	18	male	male	JJ
cord-015021-pol2qm74	5318	19	Fischer	Fischer	NNP
cord-015021-pol2qm74	5318	20	rats	rat	NNS
cord-015021-pol2qm74	5318	21	(	(	-LRB-
cord-015021-pol2qm74	5318	22	230	230	CD
cord-015021-pol2qm74	5318	23	-	-	SYM
cord-015021-pol2qm74	5318	24	250	250	CD
cord-015021-pol2qm74	5318	25	g	g	NN
cord-015021-pol2qm74	5318	26	)	)	-RRB-
cord-015021-pol2qm74	5318	27	were	be	VBD
cord-015021-pol2qm74	5318	28	subjected	subject	VBN
cord-015021-pol2qm74	5318	29	to	to	IN
cord-015021-pol2qm74	5318	30	60	60	CD
cord-015021-pol2qm74	5318	31	rain	rain	NN
cord-015021-pol2qm74	5318	32	of	of	IN
cord-015021-pol2qm74	5318	33	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5318	34	(	(	-LRB-
cord-015021-pol2qm74	5318	35	mean	mean	VB
cord-015021-pol2qm74	5319	1	arterial	arterial	JJ
cord-015021-pol2qm74	5319	2	pressure	pressure	NN
cord-015021-pol2qm74	5319	3	40	40	CD
cord-015021-pol2qm74	5319	4	mm	mm	CD
cord-015021-pol2qm74	5319	5	Hg	Hg	NNP
cord-015021-pol2qm74	5319	6	)	)	-RRB-
cord-015021-pol2qm74	5319	7	followed	follow	VBN
cord-015021-pol2qm74	5319	8	by	by	IN
cord-015021-pol2qm74	5319	9	resuscitation	resuscitation	NN
cord-015021-pol2qm74	5319	10	(	(	-LRB-
cord-015021-pol2qm74	5319	11	RS	rs	NN
cord-015021-pol2qm74	5319	12	)	)	-RRB-
cord-015021-pol2qm74	5320	1	(	(	-LRB-
cord-015021-pol2qm74	5320	2	reinfusion	reinfusion	NN
cord-015021-pol2qm74	5320	3	of	of	IN
cord-015021-pol2qm74	5320	4	shed	shed	JJ
cord-015021-pol2qm74	5320	5	blood	blood	NN
cord-015021-pol2qm74	5320	6	)	)	-RRB-
cord-015021-pol2qm74	5320	7	.	.	.
cord-015021-pol2qm74	5321	1	Hepatic	hepatic	JJ
cord-015021-pol2qm74	5321	2	ATP	ATP	NNP
cord-015021-pol2qm74	5321	3	levels	level	NNS
cord-015021-pol2qm74	5321	4	declined	decline	VBD
cord-015021-pol2qm74	5321	5	from	from	IN
cord-015021-pol2qm74	5321	6	2.3	2.3	CD
cord-015021-pol2qm74	5321	7	+	+	SYM
cord-015021-pol2qm74	5321	8	0.2	0.2	CD
cord-015021-pol2qm74	5321	9	txmol	txmol	RB
cord-015021-pol2qm74	5321	10	/	/	SYM
cord-015021-pol2qm74	5321	11	g	g	NN
cord-015021-pol2qm74	5321	12	to	to	IN
cord-015021-pol2qm74	5321	13	0.24_+0.08	0.24_+0.08	CD
cord-015021-pol2qm74	5321	14	(	(	-LRB-
cord-015021-pol2qm74	5321	15	60	60	CD
cord-015021-pol2qm74	5321	16	min	min	NN
cord-015021-pol2qm74	5321	17	shock	shock	NN
cord-015021-pol2qm74	5321	18	)	)	-RRB-
cord-015021-pol2qm74	5321	19	indicating	indicate	VBG
cord-015021-pol2qm74	5321	20	severe	severe	JJ
cord-015021-pol2qm74	5321	21	ischemia	ischemia	NN
cord-015021-pol2qm74	5321	22	,	,	,
cord-015021-pol2qm74	5321	23	and	and	CC
cord-015021-pol2qm74	5321	24	recovered	recover	VBD
cord-015021-pol2qm74	5321	25	to	to	IN
cord-015021-pol2qm74	5321	26	1.04	1.04	CD
cord-015021-pol2qm74	5321	27	-	-	HYPH
cord-015021-pol2qm74	5321	28	-0.2	-0.2	NN
cord-015021-pol2qm74	5321	29	at	at	IN
cord-015021-pol2qm74	5321	30	90	90	CD
cord-015021-pol2qm74	5321	31	min	min	NN
cord-015021-pol2qm74	5321	32	RS	rs	NN
cord-015021-pol2qm74	5321	33	.	.	.
cord-015021-pol2qm74	5322	1	To	to	TO
cord-015021-pol2qm74	5322	2	test	test	VB
cord-015021-pol2qm74	5322	3	for	for	IN
cord-015021-pol2qm74	5322	4	potential	potential	JJ
cord-015021-pol2qm74	5322	5	oxidant	oxidant	JJ
cord-015021-pol2qm74	5322	6	stress	stress	NN
cord-015021-pol2qm74	5322	7	during	during	IN
cord-015021-pol2qm74	5322	8	RS	rs	NN
cord-015021-pol2qm74	5322	9	,	,	,
cord-015021-pol2qm74	5322	10	plasma	plasma	NN
cord-015021-pol2qm74	5322	11	GSSG	GSSG	NNP
cord-015021-pol2qm74	5322	12	conc	conc	NNP
cord-015021-pol2qm74	5322	13	.	.	NNP
cord-015021-pol2qm74	5322	14	were	be	VBD
cord-015021-pol2qm74	5322	15	measured	measure	VBN
cord-015021-pol2qm74	5322	16	.	.	.
cord-015021-pol2qm74	5323	1	Although	although	IN
cord-015021-pol2qm74	5323	2	GSSG	GSSG	NNP
cord-015021-pol2qm74	5323	3	levels	level	NNS
cord-015021-pol2qm74	5323	4	increased	increase	VBD
cord-015021-pol2qm74	5323	5	by	by	IN
cord-015021-pol2qm74	5323	6	120	120	CD
cord-015021-pol2qm74	5323	7	%	%	NN
cord-015021-pol2qm74	5323	8	compared	compare	VBN
cord-015021-pol2qm74	5323	9	to	to	IN
cord-015021-pol2qm74	5323	10	baseline	baseline	JJ
cord-015021-pol2qm74	5323	11	levels	level	NNS
cord-015021-pol2qm74	5323	12	(	(	-LRB-
cord-015021-pol2qm74	5323	13	0.69!-_0.31	0.69!-_0.31	NNP
cord-015021-pol2qm74	5323	14	I.tM	I.tM	NNP
cord-015021-pol2qm74	5323	15	)	)	-RRB-
cord-015021-pol2qm74	5323	16	,	,	,
cord-015021-pol2qm74	5323	17	there	there	EX
cord-015021-pol2qm74	5323	18	was	be	VBD
cord-015021-pol2qm74	5323	19	no	no	DT
cord-015021-pol2qm74	5323	20	significant	significant	JJ
cord-015021-pol2qm74	5323	21	difference	difference	NN
cord-015021-pol2qm74	5323	22	to	to	IN
cord-015021-pol2qm74	5323	23	shamoperated	shamoperated	JJ
cord-015021-pol2qm74	5323	24	controls	control	NNS
cord-015021-pol2qm74	5323	25	.	.	.
cord-015021-pol2qm74	5324	1	Spontaneous	spontaneous	JJ
cord-015021-pol2qm74	5324	2	superoxide	superoxide	NN
cord-015021-pol2qm74	5324	3	formation	formation	NN
cord-015021-pol2qm74	5324	4	of	of	IN
cord-015021-pol2qm74	5324	5	isolated	isolate	VBN
cord-015021-pol2qm74	5324	6	KC	KC	NNP
cord-015021-pol2qm74	5324	7	was	be	VBD
cord-015021-pol2qm74	5324	8	0.32	0.32	CD
cord-015021-pol2qm74	5324	9	+	+	SYM
cord-015021-pol2qm74	5324	10	0.05	0.05	CD
cord-015021-pol2qm74	5324	11	nmol	nmol	JJ
cord-015021-pol2qm74	5324	12	O2-/min/10ecells	O2-/min/10ecells	NNP
cord-015021-pol2qm74	5324	13	(	(	-LRB-
cord-015021-pol2qm74	5324	14	KC2	KC2	NNP
cord-015021-pol2qm74	5324	15	)	)	-RRB-
cord-015021-pol2qm74	5324	16	and	and	CC
cord-015021-pol2qm74	5324	17	0.51	0.51	CD
cord-015021-pol2qm74	5324	18	+	+	CD
cord-015021-pol2qm74	5324	19	0.11	0.11	CD
cord-015021-pol2qm74	5324	20	(	(	-LRB-
cord-015021-pol2qm74	5324	21	KC3	KC3	NNP
cord-015021-pol2qm74	5324	22	)	)	-RRB-
cord-015021-pol2qm74	5324	23	in	in	IN
cord-015021-pol2qm74	5324	24	controls	control	NNS
cord-015021-pol2qm74	5324	25	and	and	CC
cord-015021-pol2qm74	5324	26	did	do	VBD
cord-015021-pol2qm74	5324	27	not	not	RB
cord-015021-pol2qm74	5324	28	change	change	VB
cord-015021-pol2qm74	5324	29	significantly	significantly	RB
cord-015021-pol2qm74	5324	30	after	after	IN
cord-015021-pol2qm74	5324	31	shock	shock	NN
cord-015021-pol2qm74	5324	32	and	and	CC
cord-015021-pol2qm74	5324	33	90	90	CD
cord-015021-pol2qm74	5324	34	rain	rain	NN
cord-015021-pol2qm74	5324	35	RS	rs	NN
cord-015021-pol2qm74	5324	36	.	.	.
cord-015021-pol2qm74	5325	1	Addition	addition	NN
cord-015021-pol2qm74	5325	2	of	of	IN
cord-015021-pol2qm74	5325	3	phorbol	phorbol	NNP
cord-015021-pol2qm74	5325	4	ester	ester	NNP
cord-015021-pol2qm74	5325	5	or	or	CC
cord-015021-pol2qm74	5325	6	opsonized	opsonize	VBN
cord-015021-pol2qm74	5325	7	zymosan	zymosan	NNP
cord-015021-pol2qm74	5325	8	to	to	IN
cord-015021-pol2qm74	5325	9	isolated	isolate	VBN
cord-015021-pol2qm74	5325	10	KC	KC	NNP
cord-015021-pol2qm74	5325	11	did	do	VBD
cord-015021-pol2qm74	5325	12	not	not	RB
cord-015021-pol2qm74	5325	13	indicate	indicate	VB
cord-015021-pol2qm74	5325	14	a	a	DT
cord-015021-pol2qm74	5325	15	priming	priming	NN
cord-015021-pol2qm74	5325	16	of	of	IN
cord-015021-pol2qm74	5325	17	these	these	DT
cord-015021-pol2qm74	5325	18	cells	cell	NNS
cord-015021-pol2qm74	5325	19	.	.	.
cord-015021-pol2qm74	5326	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	5326	2	:	:	:
cord-015021-pol2qm74	5327	1	In	in	IN
cord-015021-pol2qm74	5327	2	striking	striking	JJ
cord-015021-pol2qm74	5327	3	contrast	contrast	NN
cord-015021-pol2qm74	5327	4	to	to	IN
cord-015021-pol2qm74	5327	5	our	-PRON-	PRP$
cord-015021-pol2qm74	5327	6	previous	previous	JJ
cord-015021-pol2qm74	5327	7	findings	finding	NNS
cord-015021-pol2qm74	5327	8	with	with	IN
cord-015021-pol2qm74	5327	9	hepatic	hepatic	JJ
cord-015021-pol2qm74	5327	10	no	no	DT
cord-015021-pol2qm74	5327	11	-	-	HYPH
cord-015021-pol2qm74	5327	12	flow	flow	NN
cord-015021-pol2qm74	5327	13	ischemia	ischemia	NN
cord-015021-pol2qm74	5327	14	,	,	,
cord-015021-pol2qm74	5327	15	there	there	EX
cord-015021-pol2qm74	5327	16	is	be	VBZ
cord-015021-pol2qm74	5327	17	no	no	DT
cord-015021-pol2qm74	5327	18	evidence	evidence	NN
cord-015021-pol2qm74	5327	19	for	for	IN
cord-015021-pol2qm74	5327	20	a	a	DT
cord-015021-pol2qm74	5327	21	significant	significant	JJ
cord-015021-pol2qm74	5327	22	KC	KC	NNP
cord-015021-pol2qm74	5327	23	activation	activation	NN
cord-015021-pol2qm74	5327	24	after	after	IN
cord-015021-pol2qm74	5327	25	60	60	CD
cord-015021-pol2qm74	5327	26	min	min	NN
cord-015021-pol2qm74	5327	27	of	of	IN
cord-015021-pol2qm74	5327	28	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5327	29	shock	shock	NN
cord-015021-pol2qm74	5327	30	and	and	CC
cord-015021-pol2qm74	5327	31	up	up	IN
cord-015021-pol2qm74	5327	32	to	to	TO
cord-015021-pol2qm74	5327	33	90	90	CD
cord-015021-pol2qm74	5327	34	rain	rain	NN
cord-015021-pol2qm74	5327	35	of	of	IN
cord-015021-pol2qm74	5327	36	resuscitation	resuscitation	NN
cord-015021-pol2qm74	5327	37	.	.	.
cord-015021-pol2qm74	5328	1	Objectives	objective	NNS
cord-015021-pol2qm74	5328	2	-	-	:
cord-015021-pol2qm74	5328	3	This	this	DT
cord-015021-pol2qm74	5328	4	study	study	NN
cord-015021-pol2qm74	5328	5	investigates	investigate	VBZ
cord-015021-pol2qm74	5328	6	morphometric	morphometric	JJ
cord-015021-pol2qm74	5328	7	changes	change	NNS
cord-015021-pol2qm74	5328	8	in	in	IN
cord-015021-pol2qm74	5328	9	KC	KC	NNP
cord-015021-pol2qm74	5328	10	nltrastmcture	nltrastmcture	NN
cord-015021-pol2qm74	5328	11	which	which	WDT
cord-015021-pol2qm74	5328	12	might	may	MD
cord-015021-pol2qm74	5328	13	account	account	VB
cord-015021-pol2qm74	5328	14	for	for	IN
cord-015021-pol2qm74	5328	15	this	this	DT
cord-015021-pol2qm74	5328	16	diminution	diminution	NN
cord-015021-pol2qm74	5328	17	in	in	IN
cord-015021-pol2qm74	5328	18	phagacytosis	phagacytosis	NN
cord-015021-pol2qm74	5328	19	.	.	.
cord-015021-pol2qm74	5329	1	Materials	material	NNS
cord-015021-pol2qm74	5329	2	and	and	CC
cord-015021-pol2qm74	5329	3	methods	method	NNS
cord-015021-pol2qm74	5329	4	-Three	-Three	NNP
cord-015021-pol2qm74	5329	5	groups	group	NNS
cord-015021-pol2qm74	5329	6	of	of	IN
cord-015021-pol2qm74	5329	7	Wistar	Wistar	NNP
cord-015021-pol2qm74	5329	8	rats	rat	NNS
cord-015021-pol2qm74	5329	9	were	be	VBD
cord-015021-pol2qm74	5329	10	studied	study	VBN
cord-015021-pol2qm74	5329	11	:	:	:
cord-015021-pol2qm74	5330	1	Control	Control	NNP
cord-015021-pol2qm74	5330	2	,	,	,
cord-015021-pol2qm74	5330	3	Sham	Sham	NNP
cord-015021-pol2qm74	5330	4	-	-	HYPH
cord-015021-pol2qm74	5330	5	operated	operate	VBD
cord-015021-pol2qm74	5330	6	[	[	-LRB-
cord-015021-pol2qm74	5330	7	Sham	Sham	NNP
cord-015021-pol2qm74	5330	8	]	]	-RRB-
cord-015021-pol2qm74	5330	9	and	and	CC
cord-015021-pol2qm74	5330	10	Bile	bile	NN
cord-015021-pol2qm74	5330	11	duct	duct	NN
cord-015021-pol2qm74	5330	12	ligated	ligate	VBD
cord-015021-pol2qm74	5330	13	[	[	-LRB-
cord-015021-pol2qm74	5330	14	EDL	EDL	NNP
cord-015021-pol2qm74	5330	15	]	]	-RRB-
cord-015021-pol2qm74	5330	16	.	.	.
cord-015021-pol2qm74	5331	1	After	after	IN
cord-015021-pol2qm74	5331	2	3	3	CD
cord-015021-pol2qm74	5331	3	weeks	week	NNS
cord-015021-pol2qm74	5331	4	animals	animal	NNS
cord-015021-pol2qm74	5331	5	were	be	VBD
cord-015021-pol2qm74	5331	6	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	5331	7	and	and	CC
cord-015021-pol2qm74	5331	8	livers	liver	NNS
cord-015021-pol2qm74	5331	9	were	be	VBD
cord-015021-pol2qm74	5331	10	"	"	``
cord-015021-pol2qm74	5331	11	perfusion	perfusion	NN
cord-015021-pol2qm74	5331	12	fixed	fix	VBN
cord-015021-pol2qm74	5331	13	"	"	''
cord-015021-pol2qm74	5331	14	with	with	IN
cord-015021-pol2qm74	5331	15	3	3	CD
cord-015021-pol2qm74	5331	16	%	%	NN
cord-015021-pol2qm74	5331	17	glntaraldehyde	glntaraldehyde	NNS
cord-015021-pol2qm74	5331	18	and	and	CC
cord-015021-pol2qm74	5331	19	processed	process	VBN
cord-015021-pol2qm74	5331	20	for	for	IN
cord-015021-pol2qm74	5331	21	transmission	transmission	NN
cord-015021-pol2qm74	5331	22	electron	electron	NN
cord-015021-pol2qm74	5331	23	microscopy	microscopy	NN
cord-015021-pol2qm74	5331	24	and	and	CC
cord-015021-pol2qm74	5331	25	image	image	NN
cord-015021-pol2qm74	5331	26	analysis	analysis	NN
cord-015021-pol2qm74	5331	27	.	.	.
cord-015021-pol2qm74	5332	1	Results	result	NNS
cord-015021-pol2qm74	5332	2	-In	-In	.
cord-015021-pol2qm74	5333	1	the	the	DT
cord-015021-pol2qm74	5333	2	the	the	DT
cord-015021-pol2qm74	5333	3	BDL	BDL	NNP
cord-015021-pol2qm74	5333	4	group	group	NN
cord-015021-pol2qm74	5333	5	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	5333	6	cell	cell	NN
cord-015021-pol2qm74	5333	7	numbers	number	NNS
cord-015021-pol2qm74	5333	8	were	be	VBD
cord-015021-pol2qm74	5333	9	greatly	greatly	RB
cord-015021-pol2qm74	5333	10	increased	increase	VBN
cord-015021-pol2qm74	5333	11	.	.	.
cord-015021-pol2qm74	5334	1	Biliary	Biliary	NNP
cord-015021-pol2qm74	5334	2	ductular	ductular	JJ
cord-015021-pol2qm74	5334	3	proliferation	proliferation	NN
cord-015021-pol2qm74	5334	4	was	be	VBD
cord-015021-pol2qm74	5334	5	evident	evident	JJ
cord-015021-pol2qm74	5334	6	and	and	CC
cord-015021-pol2qm74	5334	7	sinusoidal	sinusoidal	JJ
cord-015021-pol2qm74	5334	8	spaces	space	NNS
cord-015021-pol2qm74	5334	9	were	be	VBD
cord-015021-pol2qm74	5334	10	compromised	compromise	VBN
cord-015021-pol2qm74	5334	11	.	.	.
cord-015021-pol2qm74	5335	1	Eleven	eleven	CD
cord-015021-pol2qm74	5335	2	nuclear	nuclear	JJ
cord-015021-pol2qm74	5335	3	and	and	CC
cord-015021-pol2qm74	5335	4	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	5335	5	parameters	parameter	NNS
cord-015021-pol2qm74	5335	6	were	be	VBD
cord-015021-pol2qm74	5335	7	measured	measure	VBN
cord-015021-pol2qm74	5335	8	and	and	CC
cord-015021-pol2qm74	5335	9	statistically	statistically	RB
cord-015021-pol2qm74	5335	10	significant	significant	JJ
cord-015021-pol2qm74	5335	11	results	result	NNS
cord-015021-pol2qm74	5335	12	are	be	VBP
cord-015021-pol2qm74	5335	13	summarised	summarise	VBN
cord-015021-pol2qm74	5335	14	in	in	IN
cord-015021-pol2qm74	5335	15	the	the	DT
cord-015021-pol2qm74	5335	16	RESULTS	result	NNS
cord-015021-pol2qm74	5335	17	:	:	:
cord-015021-pol2qm74	5335	18	Ascorbic	ascorbic	NN
cord-015021-pol2qm74	5335	19	acid	acid	NN
cord-015021-pol2qm74	5335	20	levels	level	NNS
cord-015021-pol2qm74	5335	21	were	be	VBD
cord-015021-pol2qm74	5335	22	slightly	slightly	RB
cord-015021-pol2qm74	5335	23	elevated	elevated	JJ
cord-015021-pol2qm74	5335	24	after	after	IN
cord-015021-pol2qm74	5335	25	the	the	DT
cord-015021-pol2qm74	5335	26	HS	HS	NNP
cord-015021-pol2qm74	5335	27	and	and	CC
cord-015021-pol2qm74	5335	28	returned	return	VBD
cord-015021-pol2qm74	5335	29	to	to	IN
cord-015021-pol2qm74	5335	30	basal	basal	NN
cord-015021-pol2qm74	5335	31	values	value	NNS
cord-015021-pol2qm74	5335	32	after	after	IN
cord-015021-pol2qm74	5335	33	120	120	CD
cord-015021-pol2qm74	5335	34	rain	rain	NN
cord-015021-pol2qm74	5335	35	.	.	.
cord-015021-pol2qm74	5336	1	Glutathione	glutathione	NN
cord-015021-pol2qm74	5336	2	concentrations	concentration	NNS
cord-015021-pol2qm74	5336	3	were	be	VBD
cord-015021-pol2qm74	5336	4	increased	increase	VBN
cord-015021-pol2qm74	5336	5	significantly	significantly	RB
cord-015021-pol2qm74	5336	6	after	after	IN
cord-015021-pol2qm74	5336	7	the	the	DT
cord-015021-pol2qm74	5336	8	HS	HS	NNP
cord-015021-pol2qm74	5336	9	and	and	CC
cord-015021-pol2qm74	5336	10	the	the	DT
cord-015021-pol2qm74	5336	11	GSH	GSH	NNP
cord-015021-pol2qm74	5336	12	levels	level	NNS
cord-015021-pol2qm74	5336	13	kept	keep	VBD
cord-015021-pol2qm74	5336	14	rising	rise	VBG
cord-015021-pol2qm74	5336	15	continuously	continuously	RB
cord-015021-pol2qm74	5336	16	to	to	IN
cord-015021-pol2qm74	5336	17	as	as	RB
cord-015021-pol2qm74	5336	18	much	much	JJ
cord-015021-pol2qm74	5336	19	as	as	IN
cord-015021-pol2qm74	5336	20	4-fold	4-fold	CD
cord-015021-pol2qm74	5336	21	of	of	IN
cord-015021-pol2qm74	5336	22	basal	basal	NN
cord-015021-pol2qm74	5336	23	levels	level	NNS
cord-015021-pol2qm74	5336	24	at	at	IN
cord-015021-pol2qm74	5336	25	the	the	DT
cord-015021-pol2qm74	5336	26	end	end	NN
cord-015021-pol2qm74	5336	27	of	of	IN
cord-015021-pol2qm74	5336	28	120	120	CD
cord-015021-pol2qm74	5336	29	min	min	NN
cord-015021-pol2qm74	5336	30	.	.	.
cord-015021-pol2qm74	5337	1	MDA	MDA	NNP
cord-015021-pol2qm74	5337	2	showed	show	VBD
cord-015021-pol2qm74	5337	3	no	no	DT
cord-015021-pol2qm74	5337	4	significant	significant	JJ
cord-015021-pol2qm74	5337	5	variation	variation	NN
cord-015021-pol2qm74	5337	6	before	before	IN
cord-015021-pol2qm74	5337	7	and	and	CC
cord-015021-pol2qm74	5337	8	after	after	IN
cord-015021-pol2qm74	5337	9	the	the	DT
cord-015021-pol2qm74	5337	10	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5337	11	shock	shock	NN
cord-015021-pol2qm74	5337	12	.	.	.
cord-015021-pol2qm74	5338	1	Plasma	plasma	NN
cord-015021-pol2qm74	5338	2	concentrations	concentration	NNS
cord-015021-pol2qm74	5338	3	of	of	IN
cord-015021-pol2qm74	5338	4	ratine	ratine	NN
cord-015021-pol2qm74	5338	5	,	,	,
cord-015021-pol2qm74	5338	6	teucine	teucine	NNP
cord-015021-pol2qm74	5338	7	,	,	,
cord-015021-pol2qm74	5338	8	isoleucine	isoleucine	NNP
cord-015021-pol2qm74	5338	9	,	,	,
cord-015021-pol2qm74	5338	10	phenylalanine	phenylalanine	NN
cord-015021-pol2qm74	5338	11	,	,	,
cord-015021-pol2qm74	5338	12	proline	proline	NN
cord-015021-pol2qm74	5338	13	,	,	,
cord-015021-pol2qm74	5338	14	threonine	threonine	NN
cord-015021-pol2qm74	5338	15	and	and	CC
cord-015021-pol2qm74	5338	16	serine	serine	NN
cord-015021-pol2qm74	5338	17	showed	show	VBD
cord-015021-pol2qm74	5338	18	significant	significant	JJ
cord-015021-pol2qm74	5338	19	increase	increase	NN
cord-015021-pol2qm74	5338	20	over	over	IN
cord-015021-pol2qm74	5338	21	basal	basal	NN
cord-015021-pol2qm74	5338	22	levels	level	NNS
cord-015021-pol2qm74	5338	23	during	during	IN
cord-015021-pol2qm74	5338	24	the	the	DT
cord-015021-pol2qm74	5338	25	whole	whole	JJ
cord-015021-pol2qm74	5338	26	ischemic	ischemic	JJ
cord-015021-pol2qm74	5338	27	period	period	NN
cord-015021-pol2qm74	5338	28	.	.	.
cord-015021-pol2qm74	5339	1	Glutamic	glutamic	NN
cord-015021-pol2qm74	5339	2	acid	acid	NN
cord-015021-pol2qm74	5339	3	was	be	VBD
cord-015021-pol2qm74	5339	4	slightly	slightly	RB
cord-015021-pol2qm74	5339	5	elevated	elevated	JJ
cord-015021-pol2qm74	5339	6	at	at	IN
cord-015021-pol2qm74	5339	7	the	the	DT
cord-015021-pol2qm74	5339	8	onset	onset	NN
cord-015021-pol2qm74	5339	9	of	of	IN
cord-015021-pol2qm74	5339	10	HS	HS	NNP
cord-015021-pol2qm74	5339	11	and	and	CC
cord-015021-pol2qm74	5339	12	remained	remain	VBD
cord-015021-pol2qm74	5339	13	the	the	DT
cord-015021-pol2qm74	5339	14	same	same	JJ
cord-015021-pol2qm74	5339	15	for	for	IN
cord-015021-pol2qm74	5339	16	the	the	DT
cord-015021-pol2qm74	5339	17	rest	rest	NN
cord-015021-pol2qm74	5339	18	of	of	IN
cord-015021-pol2qm74	5339	19	ischemic	ischemic	JJ
cord-015021-pol2qm74	5339	20	period	period	NN
cord-015021-pol2qm74	5339	21	.	.	.
cord-015021-pol2qm74	5340	1	Hydroxyproline	Hydroxyproline	NNP
cord-015021-pol2qm74	5340	2	was	be	VBD
cord-015021-pol2qm74	5340	3	significantly	significantly	RB
cord-015021-pol2qm74	5340	4	below	below	IN
cord-015021-pol2qm74	5340	5	the	the	DT
cord-015021-pol2qm74	5340	6	basal	basal	NN
cord-015021-pol2qm74	5340	7	value	value	NN
cord-015021-pol2qm74	5340	8	at	at	IN
cord-015021-pol2qm74	5340	9	the	the	DT
cord-015021-pol2qm74	5340	10	mid	mid	JJ
cord-015021-pol2qm74	5340	11	-	-	NN
cord-015021-pol2qm74	5340	12	point	point	NN
cord-015021-pol2qm74	5340	13	of	of	IN
cord-015021-pol2qm74	5340	14	ischemic	ischemic	JJ
cord-015021-pol2qm74	5340	15	period	period	NN
cord-015021-pol2qm74	5340	16	.	.	.
cord-015021-pol2qm74	5341	1	Alanine	alanine	NN
cord-015021-pol2qm74	5341	2	,	,	,
cord-015021-pol2qm74	5341	3	glycine	glycine	NN
cord-015021-pol2qm74	5341	4	,	,	,
cord-015021-pol2qm74	5341	5	histidine	histidine	NN
cord-015021-pol2qm74	5341	6	and	and	CC
cord-015021-pol2qm74	5341	7	aspartate	aspartate	NN
cord-015021-pol2qm74	5341	8	did	do	VBD
cord-015021-pol2qm74	5341	9	not	not	RB
cord-015021-pol2qm74	5341	10	change	change	VB
cord-015021-pol2qm74	5341	11	significantly	significantly	RB
cord-015021-pol2qm74	5341	12	throughout	throughout	IN
cord-015021-pol2qm74	5341	13	experimental	experimental	JJ
cord-015021-pol2qm74	5341	14	time	time	NN
cord-015021-pol2qm74	5341	15	course	course	NN
cord-015021-pol2qm74	5341	16	.	.	.
cord-015021-pol2qm74	5342	1	CONCLUSIONS	conclusion	NNS
cord-015021-pol2qm74	5342	2	:	:	:
cord-015021-pol2qm74	5342	3	(	(	-LRB-
cord-015021-pol2qm74	5342	4	1	1	LS
cord-015021-pol2qm74	5342	5	)	)	-RRB-
cord-015021-pol2qm74	5343	1	Oxidative	oxidative	JJ
cord-015021-pol2qm74	5343	2	stress	stress	NN
cord-015021-pol2qm74	5343	3	might	may	MD
cord-015021-pol2qm74	5343	4	not	not	RB
cord-015021-pol2qm74	5343	5	be	be	VB
cord-015021-pol2qm74	5343	6	severe	severe	JJ
cord-015021-pol2qm74	5343	7	in	in	IN
cord-015021-pol2qm74	5343	8	the	the	DT
cord-015021-pol2qm74	5343	9	systemic	systemic	JJ
cord-015021-pol2qm74	5343	10	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5343	11	shock	shock	NN
cord-015021-pol2qm74	5343	12	for	for	IN
cord-015021-pol2qm74	5343	13	pigs	pig	NNS
cord-015021-pol2qm74	5343	14	since	since	IN
cord-015021-pol2qm74	5343	15	no	no	DT
cord-015021-pol2qm74	5343	16	significant	significant	JJ
cord-015021-pol2qm74	5343	17	variations	variation	NNS
cord-015021-pol2qm74	5343	18	were	be	VBD
cord-015021-pol2qm74	5343	19	observed	observe	VBN
cord-015021-pol2qm74	5343	20	for	for	IN
cord-015021-pol2qm74	5343	21	ascorbic	ascorbic	NN
cord-015021-pol2qm74	5343	22	acid	acid	NN
cord-015021-pol2qm74	5343	23	and	and	CC
cord-015021-pol2qm74	5343	24	MDA	MDA	NNP
cord-015021-pol2qm74	5343	25	(	(	-LRB-
cord-015021-pol2qm74	5343	26	2	2	CD
cord-015021-pol2qm74	5343	27	)	)	-RRB-
cord-015021-pol2qm74	5344	1	the	the	DT
cord-015021-pol2qm74	5344	2	increase	increase	NN
cord-015021-pol2qm74	5344	3	of	of	IN
cord-015021-pol2qm74	5344	4	GSH	GSH	NNP
cord-015021-pol2qm74	5344	5	might	may	MD
cord-015021-pol2qm74	5344	6	be	be	VB
cord-015021-pol2qm74	5344	7	that	that	IN
cord-015021-pol2qm74	5344	8	it	-PRON-	PRP
cord-015021-pol2qm74	5344	9	was	be	VBD
cord-015021-pol2qm74	5344	10	released	release	VBN
cord-015021-pol2qm74	5344	11	from	from	IN
cord-015021-pol2qm74	5344	12	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5344	13	when	when	WRB
cord-015021-pol2qm74	5344	14	the	the	DT
cord-015021-pol2qm74	5344	15	animal	animal	NN
cord-015021-pol2qm74	5344	16	was	be	VBD
cord-015021-pol2qm74	5344	17	under	under	IN
cord-015021-pol2qm74	5344	18	systemic	systemic	JJ
cord-015021-pol2qm74	5344	19	ischemia	ischemia	NN
cord-015021-pol2qm74	5344	20	.	.	.
cord-015021-pol2qm74	5345	1	(	(	-LRB-
cord-015021-pol2qm74	5345	2	3	3	LS
cord-015021-pol2qm74	5345	3	)	)	-RRB-
cord-015021-pol2qm74	5346	1	Celzain	Celzain	NNP
cord-015021-pol2qm74	5346	2	amino	amino	NN
cord-015021-pol2qm74	5346	3	acids	acid	NNS
cord-015021-pol2qm74	5346	4	might	may	MD
cord-015021-pol2qm74	5346	5	be	be	VB
cord-015021-pol2qm74	5346	6	acting	act	VBG
cord-015021-pol2qm74	5346	7	as	as	IN
cord-015021-pol2qm74	5346	8	transmitters	transmitter	NNS
cord-015021-pol2qm74	5346	9	in	in	IN
cord-015021-pol2qm74	5346	10	the	the	DT
cord-015021-pol2qm74	5346	11	event	event	NN
cord-015021-pol2qm74	5346	12	of	of	IN
cord-015021-pol2qm74	5346	13	ischemia	ischemia	NN
cord-015021-pol2qm74	5346	14	.	.	.
cord-015021-pol2qm74	5347	1	However	however	RB
cord-015021-pol2qm74	5347	2	,	,	,
cord-015021-pol2qm74	5347	3	fm"lher	fm"lher	NN
cord-015021-pol2qm74	5347	4	investigations	investigation	NNS
cord-015021-pol2qm74	5347	5	are	be	VBP
cord-015021-pol2qm74	5347	6	needed	need	VBN
cord-015021-pol2qm74	5347	7	to	to	TO
cord-015021-pol2qm74	5347	8	clarify	clarify	VB
cord-015021-pol2qm74	5347	9	the	the	DT
cord-015021-pol2qm74	5347	10	detailed	detailed	JJ
cord-015021-pol2qm74	5347	11	mechanism	mechanism	NN
cord-015021-pol2qm74	5347	12	in	in	IN
cord-015021-pol2qm74	5347	13	regard	regard	NN
cord-015021-pol2qm74	5347	14	with	with	IN
cord-015021-pol2qm74	5347	15	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	5347	16	and	and	CC
cord-015021-pol2qm74	5347	17	amino	amino	JJ
cord-015021-pol2qm74	5347	18	acids	acid	NNS
cord-015021-pol2qm74	5347	19	.	.	.
cord-015021-pol2qm74	5348	1	Dr.	Dr.	NNP
cord-015021-pol2qm74	5348	2	Fang	Fang	NNP
cord-015021-pol2qm74	5348	3	-	-	HYPH
cord-015021-pol2qm74	5348	4	Ku	Ku	NNP
cord-015021-pol2qm74	5348	5	P'eng	P'eng	NNP
cord-015021-pol2qm74	5348	6	Taichung	Taichung	NNP
cord-015021-pol2qm74	5348	7	Veterans	Veterans	NNPS
cord-015021-pol2qm74	5348	8	General	General	NNP
cord-015021-pol2qm74	5348	9	Hospital	Hospital	NNP
cord-015021-pol2qm74	5348	10	Talchung	Talchung	NNP
cord-015021-pol2qm74	5348	11	,	,	,
cord-015021-pol2qm74	5348	12	TAIWAN	TAIWAN	NNP
cord-015021-pol2qm74	5348	13	407	407	CD
cord-015021-pol2qm74	5348	14	,	,	,
cord-015021-pol2qm74	5349	1	R.O.C.	R.O.C.	NNP
cord-015021-pol2qm74	5349	2	Jia	Jia	NNP
cord-015021-pol2qm74	5349	3	Shi	Shi	NNP
cord-015021-pol2qm74	5349	4	Yong	Yong	NNP
cord-015021-pol2qm74	5349	5	,	,	,
cord-015021-pol2qm74	5349	6	Huang	Huang	NNP
cord-015021-pol2qm74	5349	7	Zhi	Zhi	NNP
cord-015021-pol2qm74	5349	8	Oiang	Oiang	NNP
cord-015021-pol2qm74	5349	9	and	and	CC
cord-015021-pol2qm74	5350	1	Men	man	NNS
cord-015021-pol2qm74	5350	2	xian	xian	NNP
cord-015021-pol2qm74	5350	3	Jun.	June	NNP
cord-015021-pol2qm74	5351	1	In	in	IN
cord-015021-pol2qm74	5351	2	patients	patient	NNS
cord-015021-pol2qm74	5351	3	underi~	underi~	VBP
cord-015021-pol2qm74	5352	1	ent	ent	NNP
cord-015021-pol2qm74	5352	2	major	major	JJ
cord-015021-pol2qm74	5352	3	hepatic	hepatic	JJ
cord-015021-pol2qm74	5352	4	surgery	surgery	NN
cord-015021-pol2qm74	5352	5	,	,	,
cord-015021-pol2qm74	5352	6	obstructive	obstructive	JJ
cord-015021-pol2qm74	5352	7	jaundice	jaundice	NN
cord-015021-pol2qm74	5352	8	has	have	VBZ
cord-015021-pol2qm74	5352	9	been	be	VBN
cord-015021-pol2qm74	5352	10	implicated	implicate	VBN
cord-015021-pol2qm74	5352	11	with	with	IN
cord-015021-pol2qm74	5352	12	fnoreased	fnoreased	JJ
cord-015021-pol2qm74	5352	13	susceptibility	susceptibility	NN
cord-015021-pol2qm74	5352	14	to	to	IN
cord-015021-pol2qm74	5352	15	sepsis	sepsis	NN
cord-015021-pol2qm74	5352	16	and	and	CC
cord-015021-pol2qm74	5352	17	liver	liver	NN
cord-015021-pol2qm74	5352	18	failure	failure	NN
cord-015021-pol2qm74	5352	19	.	.	.
cord-015021-pol2qm74	5353	1	Jaundice	jaundice	NN
cord-015021-pol2qm74	5353	2	was	be	VBD
cord-015021-pol2qm74	5353	3	said	say	VBN
cord-015021-pol2qm74	5353	4	to	to	IN
cord-015021-pol2qm74	5353	5	he	-PRON-	PRP
cord-015021-pol2qm74	5353	6	associated	associate	VBD
cord-015021-pol2qm74	5353	7	with	with	IN
cord-015021-pol2qm74	5353	8	derangement	derangement	NN
cord-015021-pol2qm74	5353	9	of	of	IN
cord-015021-pol2qm74	5353	10	iamune	iamune	JJ
cord-015021-pol2qm74	5353	11	function	function	NN
cord-015021-pol2qm74	5353	12	and	and	CC
cord-015021-pol2qm74	5353	13	result	result	VB
cord-015021-pol2qm74	5353	14	in	in	IN
cord-015021-pol2qm74	5353	15	expression	expression	NN
cord-015021-pol2qm74	5353	16	of	of	IN
cord-015021-pol2qm74	5353	17	pr,:.inflar	pr,:.inflar	CD
cord-015021-pol2qm74	5353	18	...	...	:
cord-015021-pol2qm74	5353	19	aatory	aatory	NNP
cord-015021-pol2qm74	5353	20	cytoki~	cytoki~	.
cord-015021-pol2qm74	5354	1	es	es	XX
cord-015021-pol2qm74	5354	2	that	that	DT
cord-015021-pol2qm74	5354	3	cause	cause	VBP
cord-015021-pol2qm74	5354	4	hepatooellular	hepatooellular	NNP
cord-015021-pol2qm74	5354	5	damage	damage	NN
cord-015021-pol2qm74	5354	6	.	.	.
cord-015021-pol2qm74	5355	1	This	this	DT
cord-015021-pol2qm74	5355	2	study	study	NN
cord-015021-pol2qm74	5355	3	is	be	VBZ
cord-015021-pol2qm74	5355	4	~.o	~.o	NNP
cord-015021-pol2qm74	5355	5	investigate	investigate	VB
cord-015021-pol2qm74	5355	6	the	the	DT
cord-015021-pol2qm74	5355	7	effects	effect	NNS
cord-015021-pol2qm74	5355	8	,	,	,
cord-015021-pol2qm74	5355	9	.,t	.,t	NNP
cord-015021-pol2qm74	5355	10	lip,~polysaccharide(LPS)rats	lip,~polysaccharide(LPS)rats	NNP
cord-015021-pol2qm74	5355	11	.	.	.
cord-015021-pol2qm74	5356	1	Jaundice	jaundice	NN
cord-015021-pol2qm74	5356	2	were	be	VBD
cord-015021-pol2qm74	5356	3	produced	produce	VBN
cord-015021-pol2qm74	5356	4	in	in	IN
cord-015021-pol2qm74	5356	5	healthy	healthy	JJ
cord-015021-pol2qm74	5356	6	~istar	~istar	CD
cord-015021-pol2qm74	5356	7	rats	rat	NNS
cord-015021-pol2qm74	5356	8	of	of	IN
cord-015021-pol2qm74	5356	9	either	either	DT
cord-015021-pol2qm74	5356	10	sex	sex	NN
cord-015021-pol2qm74	5356	11	weighing	weigh	VBG
cord-015021-pol2qm74	5356	12	180	180	CD
cord-015021-pol2qm74	5356	13	-	-	SYM
cord-015021-pol2qm74	5356	14	220	220	CD
cord-015021-pol2qm74	5356	15	m~	m~	XX
cord-015021-pol2qm74	5356	16	by	by	IN
cord-015021-pol2qm74	5356	17	common	common	JJ
cord-015021-pol2qm74	5356	18	hi	hi	UH
cord-015021-pol2qm74	5356	19	l~	l~	XX
cord-015021-pol2qm74	5357	1	duet	duet	NNP
cord-015021-pol2qm74	5357	2	l	l	NNP
cord-015021-pol2qm74	5358	1	igation(Bl)L).Seven	igation(Bl)L).Seven	NNP
cord-015021-pol2qm74	5358	2	days	day	NNS
cord-015021-pol2qm74	5358	3	post	post	NNP
cord-015021-pol2qm74	5358	4	l	l	NNP
cord-015021-pol2qm74	5358	5	igation	igation	NN
cord-015021-pol2qm74	5358	6	,	,	,
cord-015021-pol2qm74	5358	7	rats	rat	NNS
cord-015021-pol2qm74	5358	8	were	be	VBD
cord-015021-pol2qm74	5358	9	given	give	VBN
cord-015021-pol2qm74	5358	10	LPS(236.gg.10)0.7rag	LPS(236.gg.10)0.7rag	NNP
cord-015021-pol2qm74	5359	1	/kg	/kg	NFP
cord-015021-pol2qm74	5359	2	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	5359	3	.	.	.
cord-015021-pol2qm74	5360	1	At	at	IN
cord-015021-pol2qm74	5360	2	the	the	DT
cord-015021-pol2qm74	5360	3	end	end	NN
cord-015021-pol2qm74	5360	4	,	,	,
cord-015021-pol2qm74	5360	5	:	:	:
cord-015021-pol2qm74	5360	6	,	,	,
cord-015021-pol2qm74	5360	7	f	f	NNP
cord-015021-pol2qm74	5360	8	l	l	NNP
cord-015021-pol2qm74	5360	9	,	,	,
cord-015021-pol2qm74	5360	10	gand	gand	NNP
cord-015021-pol2qm74	5360	11	5	5	CD
cord-015021-pol2qm74	5360	12	hours	hour	NNS
cord-015021-pol2qm74	5360	13	after	after	IN
cord-015021-pol2qm74	5360	14	LP$	LP$	NNP
cord-015021-pol2qm74	5360	15	ehanllenge	ehanllenge	NN
cord-015021-pol2qm74	5360	16	,	,	,
cord-015021-pol2qm74	5360	17	liver	liver	NN
cord-015021-pol2qm74	5360	18	were	be	VBD
cord-015021-pol2qm74	5360	19	removed	remove	VBN
cord-015021-pol2qm74	5360	20	and	and	CC
cord-015021-pol2qm74	5360	21	prepared	prepare	VBN
cord-015021-pol2qm74	5360	22	for	for	IN
cord-015021-pol2qm74	5360	23	forzen	forzen	NN
cord-015021-pol2qm74	5360	24	sections	section	NNS
cord-015021-pol2qm74	5360	25	immediately	immediately	RB
cord-015021-pol2qm74	5360	26	.	.	.
cord-015021-pol2qm74	5361	1	I)emonstration	i)emonstration	NN
cord-015021-pol2qm74	5361	2	of	of	IN
cord-015021-pol2qm74	5361	3	INF	INF	NNP
cord-015021-pol2qm74	5361	4	in	in	IN
cord-015021-pol2qm74	5361	5	liver	liver	NN
cord-015021-pol2qm74	5361	6	parenchyna	parenchyna	NN
cord-015021-pol2qm74	5361	7	were	be	VBD
cord-015021-pol2qm74	5361	8	performed	perform	VBN
cord-015021-pol2qm74	5361	9	by	by	IN
cord-015021-pol2qm74	5361	10	method	method	NN
cord-015021-pol2qm74	5361	11	of	of	IN
cord-015021-pol2qm74	5361	12	ABU	ABU	NNP
cord-015021-pol2qm74	5362	1	i	i	PRP
cord-015021-pol2qm74	5362	2	~	~	NFP
cord-015021-pol2qm74	5362	3	munohistochemistry	munohistochemistry	NNP
cord-015021-pol2qm74	5362	4	using	use	VBG
cord-015021-pol2qm74	5362	5	r	r	NNP
cord-015021-pol2qm74	5362	6	~	~	CD
cord-015021-pol2qm74	5362	7	onoolonal	onoolonal	JJ
cord-015021-pol2qm74	5362	8	antibody	antibody	NN
cord-015021-pol2qm74	5362	9	against	against	IN
cord-015021-pol2qm74	5362	10	TNF	TNF	NNP
cord-015021-pol2qm74	5362	11	,	,	,
cord-015021-pol2qm74	5362	12	Leve	Leve	NNP
cord-015021-pol2qm74	5362	13	of	of	IN
cord-015021-pol2qm74	5362	14	mRNA	mRNA	NNP
cord-015021-pol2qm74	5362	15	for	for	IN
cord-015021-pol2qm74	5362	16	TNF	TNF	NNP
cord-015021-pol2qm74	5363	1	~ere	~ere	NNP
cord-015021-pol2qm74	5363	2	measured	measure	VBN
cord-015021-pol2qm74	5363	3	by	by	IN
cord-015021-pol2qm74	5363	4	in	in	IN
cord-015021-pol2qm74	5363	5	-	-	HYPH
cord-015021-pol2qm74	5363	6	situ	situ	NN
cord-015021-pol2qm74	5363	7	hybridization	hybridization	NN
cord-015021-pol2qm74	5363	8	using	use	VBG
cord-015021-pol2qm74	5363	9	biotin	biotin	NN
cord-015021-pol2qm74	5363	10	-	-	HYPH
cord-015021-pol2qm74	5363	11	labeled	label	VBN
cord-015021-pol2qm74	5363	12	eDNA	edna	NN
cord-015021-pol2qm74	5363	13	probe	probe	NN
cord-015021-pol2qm74	5363	14	.	.	.
cord-015021-pol2qm74	5364	1	Results	result	NNS
cord-015021-pol2qm74	5364	2	sho'~ed	sho'~ed	NNP
cord-015021-pol2qm74	5364	3	that	that	IN
cord-015021-pol2qm74	5364	4	TNF	TNF	NNP
cord-015021-pol2qm74	5364	5	stained	stain	VBN
cord-015021-pol2qm74	5364	6	granules	granule	NNS
cord-015021-pol2qm74	5364	7	appeared	appear	VBD
cord-015021-pol2qm74	5364	8	in	in	IN
cord-015021-pol2qm74	5364	9	kup~'fer	kup~'fer	NNP
cord-015021-pol2qm74	5364	10	eell~	eell~	NNPS
cord-015021-pol2qm74	5364	11	and	and	CC
cord-015021-pol2qm74	5364	12	polymorphonuclear	polymorphonuclear	NNP
cord-015021-pol2qm74	5364	13	leukocytes(PNNl	leukocytes(PNNl	NNP
cord-015021-pol2qm74	5364	14	,	,	,
cord-015021-pol2qm74	5364	15	but	but	CC
cord-015021-pol2qm74	5364	16	not	not	RB
cord-015021-pol2qm74	5364	17	in	in	IN
cord-015021-pol2qm74	5364	18	hepatoeytes	hepatoeyte	NNS
cord-015021-pol2qm74	5364	19	nor	nor	CC
cord-015021-pol2qm74	5364	20	endothelial	endothelial	JJ
cord-015021-pol2qm74	5364	21	eel	eel	NN
cord-015021-pol2qm74	5364	22	Is	be	VBZ
cord-015021-pol2qm74	5364	23	.	.	.
cord-015021-pol2qm74	5365	1	They	-PRON-	PRP
cord-015021-pol2qm74	5365	2	~'ere	~'ere	RB
cord-015021-pol2qm74	5365	3	located	locate	VBN
cord-015021-pol2qm74	5365	4	within	within	IN
cord-015021-pol2qm74	5365	5	cytoplasms	cytoplasm	NNS
cord-015021-pol2qm74	5365	6	and	and	CC
cord-015021-pol2qm74	5365	7	peaked	peak	VBD
cord-015021-pol2qm74	5365	8	at	at	IN
cord-015021-pol2qm74	5365	9	3	3	CD
cord-015021-pol2qm74	5365	10	-	-	SYM
cord-015021-pol2qm74	5365	11	5	5	CD
cord-015021-pol2qm74	5365	12	hours	hour	NNS
cord-015021-pol2qm74	5365	13	after	after	IN
cord-015021-pol2qm74	5365	14	LPS	LPS	NNP
cord-015021-pol2qm74	5365	15	ohal	ohal	NN
cord-015021-pol2qm74	5365	16	lenge	lenge	NNP
cord-015021-pol2qm74	5365	17	.	.	.
cord-015021-pol2qm74	5366	1	There	there	EX
cord-015021-pol2qm74	5366	2	was	be	VBD
cord-015021-pol2qm74	5366	3	vocomitant	vocomitant	JJ
cord-015021-pol2qm74	5366	4	TNFmRNA	tnfmrna	NN
cord-015021-pol2qm74	5366	5	expression	expression	NN
cord-015021-pol2qm74	5366	6	but	but	CC
cord-015021-pol2qm74	5366	7	peaked	peak	VBD
cord-015021-pol2qm74	5366	8	earlier	early	JJR
cord-015021-pol2qm74	5366	9	1	1	CD
cord-015021-pol2qm74	5366	10	hour	hour	NN
cord-015021-pol2qm74	5366	11	post	post	NN
cord-015021-pol2qm74	5366	12	LPS	lps	NN
cord-015021-pol2qm74	5366	13	challenge	challenge	NN
cord-015021-pol2qm74	5366	14	.	.	.
cord-015021-pol2qm74	5367	1	TNFmRNA	TNFmRNA	NNP
cord-015021-pol2qm74	5367	2	vcere	vcere	NNP
cord-015021-pol2qm74	5367	3	detected	detect	VBN
cord-015021-pol2qm74	5367	4	notably	notably	RB
cord-015021-pol2qm74	5367	5	in	in	IN
cord-015021-pol2qm74	5367	6	necrotic	necrotic	JJ
cord-015021-pol2qm74	5367	7	area	area	NN
cord-015021-pol2qm74	5367	8	and	and	CC
cord-015021-pol2qm74	5367	9	barely	barely	RB
cord-015021-pol2qm74	5367	10	in	in	IN
cord-015021-pol2qm74	5367	11	BDL	BDL	NNP
cord-015021-pol2qm74	5367	12	rats	rat	NNS
cord-015021-pol2qm74	5368	1	~ithout	~ithout	JJ
cord-015021-pol2qm74	5369	1	LPS	LPS	NNP
cord-015021-pol2qm74	5369	2	challenge	challenge	NN
cord-015021-pol2qm74	5369	3	.	.	.
cord-015021-pol2qm74	5370	1	It	-PRON-	PRP
cord-015021-pol2qm74	5370	2	is	be	VBZ
cord-015021-pol2qm74	5370	3	therefore	therefore	RB
cord-015021-pol2qm74	5370	4	postulated	postulate	VBN
cord-015021-pol2qm74	5370	5	that	that	IN
cord-015021-pol2qm74	5370	6	production	production	NN
cord-015021-pol2qm74	5370	7	of	of	IN
cord-015021-pol2qm74	5370	8	TNF	TNF	NNP
cord-015021-pol2qm74	5370	9	by	by	IN
cord-015021-pol2qm74	5370	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5370	11	effeetor	effeetor	NN
cord-015021-pol2qm74	5370	12	cells	cell	NNS
cord-015021-pol2qm74	5370	13	-	-	HYPH
cord-015021-pol2qm74	5370	14	kupffer	kupffer	NN
cord-015021-pol2qm74	5370	15	cell	cell	NN
cord-015021-pol2qm74	5370	16	and	and	CC
cord-015021-pol2qm74	5370	17	PHN	PHN	NNP
cord-015021-pol2qm74	5370	18	in	in	IN
cord-015021-pol2qm74	5370	19	site	site	NN
cord-015021-pol2qm74	5370	20	,	,	,
cord-015021-pol2qm74	5370	21	in	in	IN
cord-015021-pol2qm74	5370	22	the	the	DT
cord-015021-pol2qm74	5370	23	obstructive	obstructive	JJ
cord-015021-pol2qm74	5370	24	jaundice	jaundice	NN
cord-015021-pol2qm74	5370	25	rats	rat	NNS
cord-015021-pol2qm74	5370	26	during	during	IN
cord-015021-pol2qm74	5370	27	sepsis	sepsis	NN
cord-015021-pol2qm74	5370	28	may	may	MD
cord-015021-pol2qm74	5370	29	atribute	atribute	VB
cord-015021-pol2qm74	5370	30	to	to	IN
cord-015021-pol2qm74	5370	31	the	the	DT
cord-015021-pol2qm74	5370	32	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	5370	33	damage	damage	NN
cord-015021-pol2qm74	5370	34	.	.	.
cord-015021-pol2qm74	5371	1	It	-PRON-	PRP
cord-015021-pol2qm74	5371	2	also	also	RB
cord-015021-pol2qm74	5371	3	provide	provide	VBP
cord-015021-pol2qm74	5371	4	evidence	evidence	NN
cord-015021-pol2qm74	5371	5	for	for	IN
cord-015021-pol2qm74	5371	6	the	the	DT
cord-015021-pol2qm74	5371	7	beneficial	beneficial	JJ
cord-015021-pol2qm74	5371	8	effects	effect	NNS
cord-015021-pol2qm74	5371	9	of	of	IN
cord-015021-pol2qm74	5371	10	early	early	JJ
cord-015021-pol2qm74	5371	11	release	release	NN
cord-015021-pol2qm74	5371	12	of	of	IN
cord-015021-pol2qm74	5371	13	biliary	biliary	JJ
cord-015021-pol2qm74	5371	14	obstruction	obstruction	NN
cord-015021-pol2qm74	5371	15	.	.	.
cord-015021-pol2qm74	5372	1	In	in	IN
cord-015021-pol2qm74	5372	2	the	the	DT
cord-015021-pol2qm74	5372	3	present	present	JJ
cord-015021-pol2qm74	5372	4	study	study	NN
cord-015021-pol2qm74	5372	5	,	,	,
cord-015021-pol2qm74	5372	6	an	an	DT
cord-015021-pol2qm74	5372	7	animal	animal	NN
cord-015021-pol2qm74	5372	8	model	model	NN
cord-015021-pol2qm74	5372	9	of	of	IN
cord-015021-pol2qm74	5372	10	A0C	a0c	NN
cord-015021-pol2qm74	5372	11	in	in	IN
cord-015021-pol2qm74	5372	12	Wlstar	Wlstar	NNP
cord-015021-pol2qm74	5372	13	rats	rat	NNS
cord-015021-pol2qm74	5372	14	was	be	VBD
cord-015021-pol2qm74	5372	15	developed	develop	VBN
cord-015021-pol2qm74	5372	16	by	by	IN
cord-015021-pol2qm74	5372	17	tigatlng	tigatlng	NNP
cord-015021-pol2qm74	5372	18	the	the	DT
cord-015021-pol2qm74	5372	19	common	common	JJ
cord-015021-pol2qm74	5372	20	bite	bite	NN
cord-015021-pol2qm74	5372	21	duct	duct	NN
cord-015021-pol2qm74	5372	22	and	and	CC
cord-015021-pol2qm74	5372	23	injecting	inject	VBG
cord-015021-pol2qm74	5372	24	D.3mt	D.3mt	NNP
cord-015021-pol2qm74	5372	25	solution	solution	NN
cord-015021-pol2qm74	5372	26	of	of	IN
cord-015021-pol2qm74	5372	27	E.	E.	NNP
cord-015021-pol2qm74	5372	28	goli	goli	NNP
cord-015021-pol2qm74	5372	29	%	%	NN
cord-015021-pol2qm74	5372	30	B	B	NNP
cord-015021-pol2qm74	5372	31	,	,	,
cord-015021-pol2qm74	5372	32	(	(	-LRB-
cord-015021-pol2qm74	5372	33	g×10	g×10	NNP
cord-015021-pol2qm74	5372	34	'	'	POS
cord-015021-pol2qm74	5372	35	efm	efm	NNP
cord-015021-pol2qm74	5372	36	/	/	SYM
cord-015021-pol2qm74	5372	37	mt	mt	NNP
cord-015021-pol2qm74	5372	38	)	)	-RRB-
cord-015021-pol2qm74	5372	39	into	into	IN
cord-015021-pol2qm74	5372	40	the	the	DT
cord-015021-pol2qm74	5372	41	bite	bite	NN
cord-015021-pol2qm74	5372	42	duct	duct	NN
cord-015021-pol2qm74	5372	43	.	.	.
cord-015021-pol2qm74	5373	1	The	the	DT
cord-015021-pol2qm74	5373	2	mortality	mortality	NN
cord-015021-pol2qm74	5373	3	rate	rate	NN
cord-015021-pol2qm74	5373	4	was	be	VBD
cord-015021-pol2qm74	5373	5	40~	40~	CD
cord-015021-pol2qm74	5373	6	at	at	IN
cord-015021-pol2qm74	5373	7	48h	48h	NNS
cord-015021-pol2qm74	5373	8	after	after	IN
cord-015021-pol2qm74	5373	9	AOC	AOC	NNP
cord-015021-pol2qm74	5373	10	.	.	.
cord-015021-pol2qm74	5374	1	At	at	IN
cord-015021-pol2qm74	5374	2	6	6	CD
cord-015021-pol2qm74	5374	3	,	,	,
cord-015021-pol2qm74	5374	4	12	12	CD
cord-015021-pol2qm74	5374	5	,	,	,
cord-015021-pol2qm74	5374	6	24	24	CD
cord-015021-pol2qm74	5374	7	,	,	,
cord-015021-pol2qm74	5374	8	48h	48h	NNS
cord-015021-pol2qm74	5374	9	after	after	IN
cord-015021-pol2qm74	5374	10	AOC	AOC	NNP
cord-015021-pol2qm74	5374	11	,	,	,
cord-015021-pol2qm74	5374	12	KCs	kc	NNS
cord-015021-pol2qm74	5374	13	were	be	VBD
cord-015021-pol2qm74	5374	14	isotated	isotate	VBN
cord-015021-pol2qm74	5374	15	and	and	CC
cord-015021-pol2qm74	5374	16	cultured	culture	VBN
cord-015021-pol2qm74	5374	17	atone	atone	NN
cord-015021-pol2qm74	5374	18	or	or	CC
cord-015021-pol2qm74	5374	19	cocuttured	cocutture	VBN
cord-015021-pol2qm74	5374	20	with	with	IN
cord-015021-pol2qm74	5374	21	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5374	22	to	to	TO
cord-015021-pol2qm74	5374	23	evaluate	evaluate	VB
cord-015021-pol2qm74	5374	24	the	the	DT
cord-015021-pol2qm74	5374	25	modulation	modulation	NN
cord-015021-pol2qm74	5374	26	effect	effect	NN
cord-015021-pol2qm74	5374	27	of	of	IN
cord-015021-pol2qm74	5374	28	Kgs	Kgs	NNP
cord-015021-pol2qm74	5374	29	on	on	IN
cord-015021-pol2qm74	5374	30	hepatoeyte	hepatoeyte	NNP
cord-015021-pol2qm74	5374	31	protein	protein	NN
cord-015021-pol2qm74	5374	32	synthesis	synthesis	NN
cord-015021-pol2qm74	5374	33	.	.	.
cord-015021-pol2qm74	5375	1	The	the	DT
cord-015021-pol2qm74	5375	2	results	result	NNS
cord-015021-pol2qm74	5375	3	showed	show	VBD
cord-015021-pol2qm74	5375	4	that	that	IN
cord-015021-pol2qm74	5375	5	tactodehydrogenase	tactodehydrogenase	IN
cord-015021-pol2qm74	5375	6	leakage	leakage	NN
cord-015021-pol2qm74	5375	7	was	be	VBD
cord-015021-pol2qm74	5375	8	increased	increase	VBN
cord-015021-pol2qm74	5375	9	progressively	progressively	RB
cord-015021-pol2qm74	5375	10	as	as	IN
cord-015021-pol2qm74	5375	11	the	the	DT
cord-015021-pol2qm74	5375	12	injured	injured	JJ
cord-015021-pol2qm74	5375	13	k~	k~	CD
cord-015021-pol2qm74	5375	14	function	function	NN
cord-015021-pol2qm74	5375	15	and	and	CC
cord-015021-pol2qm74	5375	16	structure	structure	NN
cord-015021-pol2qm74	5375	17	developed	develop	VBD
cord-015021-pol2qm74	5375	18	.	.	.
cord-015021-pol2qm74	5376	1	TNF	TNF	NNP
cord-015021-pol2qm74	5376	2	and	and	CC
cord-015021-pol2qm74	5376	3	IL	IL	NNP
cord-015021-pol2qm74	5376	4	-	-	:
cord-015021-pol2qm74	5376	5	I	I	NNP
cord-015021-pol2qm74	5376	6	tn	tn	NNP
cord-015021-pol2qm74	5377	1	the	the	DT
cord-015021-pol2qm74	5377	2	supernatant	supernatant	NN
cord-015021-pol2qm74	5377	3	were	be	VBD
cord-015021-pol2qm74	5377	4	detected	detect	VBN
cord-015021-pol2qm74	5377	5	with	with	IN
cord-015021-pol2qm74	5377	6	the	the	DT
cord-015021-pol2qm74	5377	7	peak	peak	NN
cord-015021-pol2qm74	5377	8	values	value	NNS
cord-015021-pol2qm74	5377	9	at	at	IN
cord-015021-pol2qm74	5377	10	12h	12h	CD
cord-015021-pol2qm74	5377	11	after	after	IN
cord-015021-pol2qm74	5377	12	AOC	AOC	NNP
cord-015021-pol2qm74	5377	13	.	.	.
cord-015021-pol2qm74	5378	1	At	at	IN
cord-015021-pol2qm74	5378	2	48h	48h	NNS
cord-015021-pol2qm74	5378	3	after	after	IN
cord-015021-pol2qm74	5378	4	AOC	AOC	NNP
cord-015021-pol2qm74	5378	5	,	,	,
cord-015021-pol2qm74	5378	6	~-teueine	~-teueine	NNP
cord-015021-pol2qm74	5378	7	incorporation	incorporation	NN
cord-015021-pol2qm74	5378	8	was	be	VBD
cord-015021-pol2qm74	5378	9	obviousty	obviousty	NNP
cord-015021-pol2qm74	5378	10	decreased	decrease	VBD
cord-015021-pol2qm74	5378	11	in	in	IN
cord-015021-pol2qm74	5378	12	the	the	DT
cord-015021-pol2qm74	5378	13	normal	normal	JJ
cord-015021-pol2qm74	5378	14	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5378	15	eocuttured	eocutture	VBN
cord-015021-pol2qm74	5378	16	with	with	IN
cord-015021-pol2qm74	5378	17	stimulated	stimulate	VBN
cord-015021-pol2qm74	5378	18	KCs	kc	NNS
cord-015021-pol2qm74	5378	19	compared	compare	VBN
cord-015021-pol2qm74	5378	20	to	to	IN
cord-015021-pol2qm74	5378	21	the	the	DT
cord-015021-pol2qm74	5378	22	uormai	uormai	NNP
cord-015021-pol2qm74	5378	23	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	5378	24	cultured	cultured	JJ
cord-015021-pol2qm74	5378	25	group	group	NN
cord-015021-pol2qm74	5378	26	(	(	-LRB-
cord-015021-pol2qm74	5378	27	P<8.01	p<8.01	JJ
cord-015021-pol2qm74	5378	28	)	)	-RRB-
cord-015021-pol2qm74	5378	29	,	,	,
cord-015021-pol2qm74	5378	30	but	but	CC
cord-015021-pol2qm74	5378	31	it	-PRON-	PRP
cord-015021-pol2qm74	5378	32	was	be	VBD
cord-015021-pol2qm74	5378	33	slgnificantiy	slgnificantiy	NNP
cord-015021-pol2qm74	5378	34	increased	increase	VBD
cord-015021-pol2qm74	5378	35	in	in	IN
cord-015021-pol2qm74	5378	36	the	the	DT
cord-015021-pol2qm74	5378	37	group	group	NN
cord-015021-pol2qm74	5378	38	cocuLtured	coculture	VBN
cord-015021-pol2qm74	5378	39	with	with	IN
cord-015021-pol2qm74	5378	40	normal	normal	JJ
cord-015021-pol2qm74	5378	41	KCs	kc	NNS
cord-015021-pol2qm74	5378	42	.	.	.
cord-015021-pol2qm74	5379	1	In	in	IN
cord-015021-pol2qm74	5379	2	the	the	DT
cord-015021-pol2qm74	5379	3	A0C	A0C	NNP
cord-015021-pol2qm74	5379	4	group	group	NN
cord-015021-pol2qm74	5379	5	,	,	,
cord-015021-pol2qm74	5379	6	'	'	''
cord-015021-pol2qm74	5379	7	H	H	NNP
cord-015021-pol2qm74	5379	8	-	-	HYPH
cord-015021-pol2qm74	5379	9	teuclne	teuclne	NNP
cord-015021-pol2qm74	5379	10	ineorporatien	ineorporatien	NNP
cord-015021-pol2qm74	5379	11	was	be	VBD
cord-015021-pol2qm74	5379	12	decreased	decrease	VBN
cord-015021-pol2qm74	5379	13	progressively	progressively	RB
cord-015021-pol2qm74	5379	14	in	in	IN
cord-015021-pol2qm74	5379	15	the	the	DT
cord-015021-pol2qm74	5379	16	injured	injure	VBN
cord-015021-pol2qm74	5379	17	hepatoeytes	hepatoeyte	NNS
cord-015021-pol2qm74	5379	18	cocuttured	cocutture	VBD
cord-015021-pol2qm74	5379	19	with	with	IN
cord-015021-pol2qm74	5379	20	stimuLatedKgs	stimuLatedKgs	NNP
cord-015021-pol2qm74	5380	1	and	and	CC
cord-015021-pol2qm74	5380	2	it	-PRON-	PRP
cord-015021-pol2qm74	5380	3	was	be	VBD
cord-015021-pol2qm74	5380	4	markedly	markedly	RB
cord-015021-pol2qm74	5380	5	elevated	elevate	VBN
cord-015021-pol2qm74	5380	6	when	when	WRB
cord-015021-pol2qm74	5380	7	cocuttured	cocuttured	JJ
cord-015021-pol2qm74	5380	8	wlthnormat	wlthnormat	NNP
cord-015021-pol2qm74	5380	9	KCs	KCs	NNPS
cord-015021-pol2qm74	5380	10	at	at	IN
cord-015021-pol2qm74	5380	11	48h	48h	NNS
cord-015021-pol2qm74	5380	12	after	after	IN
cord-015021-pol2qm74	5380	13	A0C	A0C	NNP
cord-015021-pol2qm74	5380	14	(	(	-LRB-
cord-015021-pol2qm74	5380	15	P<0	P<0	NNP
cord-015021-pol2qm74	5380	16	.	.	.
cord-015021-pol2qm74	5381	1	Og	Og	NNP
cord-015021-pol2qm74	5381	2	)	)	-RRB-
cord-015021-pol2qm74	5381	3	.	.	.
cord-015021-pol2qm74	5382	1	It	-PRON-	PRP
cord-015021-pol2qm74	5382	2	is	be	VBZ
cord-015021-pol2qm74	5382	3	concluded	conclude	VBN
cord-015021-pol2qm74	5382	4	that	that	IN
cord-015021-pol2qm74	5382	5	the	the	DT
cord-015021-pol2qm74	5382	6	impaired	impair	VBN
cord-015021-pol2qm74	5382	7	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	5382	8	proterin	proterin	NN
cord-015021-pol2qm74	5382	9	synthesis	synthesis	NN
cord-015021-pol2qm74	5382	10	was	be	VBD
cord-015021-pol2qm74	5382	11	directly	directly	RB
cord-015021-pol2qm74	5382	12	mediated	mediate	VBN
cord-015021-pol2qm74	5382	13	hy	hy	NNP
cord-015021-pol2qm74	5382	14	the	the	DT
cord-015021-pol2qm74	5382	15	stimulated	stimulate	VBN
cord-015021-pol2qm74	5382	16	KC	KC	NNP
cord-015021-pol2qm74	5382	17	function	function	NN
cord-015021-pol2qm74	5382	18	during	during	IN
cord-015021-pol2qm74	5382	19	AOC	AOC	NNP
cord-015021-pol2qm74	5382	20	.	.	.
cord-015021-pol2qm74	5383	1	Such	such	JJ
cord-015021-pol2qm74	5383	2	a	a	DT
cord-015021-pol2qm74	5383	3	mechanism	mechanism	NN
cord-015021-pol2qm74	5383	4	possibly	possibly	RB
cord-015021-pol2qm74	5383	5	may	may	MD
cord-015021-pol2qm74	5383	6	be	be	VB
cord-015021-pol2qm74	5383	7	involved	involve	VBN
cord-015021-pol2qm74	5383	8	in	in	IN
cord-015021-pol2qm74	5383	9	the	the	DT
cord-015021-pol2qm74	5383	10	patho0ensis	patho0ensi	NNS
cord-015021-pol2qm74	5383	11	of	of	IN
cord-015021-pol2qm74	5383	12	hepatic	hepatic	JJ
cord-015021-pol2qm74	5383	13	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5383	14	and	and	CC
cord-015021-pol2qm74	5383	15	M0F	m0f	NN
cord-015021-pol2qm74	5383	16	following	follow	VBG
cord-015021-pol2qm74	5383	17	h06	h06	CD
cord-015021-pol2qm74	5383	18	.	.	.
cord-015021-pol2qm74	5384	1	"	"	''
cord-015021-pol2qm74	5385	1	The	the	DT
cord-015021-pol2qm74	5385	2	project	project	NN
cord-015021-pol2qm74	5385	3	supported	support	VBN
cord-015021-pol2qm74	5385	4	by	by	IN
cord-015021-pol2qm74	5385	5	NSFC	NSFC	NNP
cord-015021-pol2qm74	5385	6	.	.	.
cord-015021-pol2qm74	5386	1	In	in	IN
cord-015021-pol2qm74	5386	2	the	the	DT
cord-015021-pol2qm74	5386	3	past	past	JJ
cord-015021-pol2qm74	5386	4	few	few	JJ
cord-015021-pol2qm74	5386	5	years	year	NNS
cord-015021-pol2qm74	5386	6	it	-PRON-	PRP
cord-015021-pol2qm74	5386	7	has	have	VBZ
cord-015021-pol2qm74	5386	8	become	become	VBN
cord-015021-pol2qm74	5386	9	evident	evident	JJ
cord-015021-pol2qm74	5386	10	that	that	IN
cord-015021-pol2qm74	5386	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	5386	12	are	be	VBP
cord-015021-pol2qm74	5386	13	implicated	implicate	VBN
cord-015021-pol2qm74	5386	14	in	in	IN
cord-015021-pol2qm74	5386	15	various	various	JJ
cord-015021-pol2qm74	5386	16	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	5386	17	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5386	18	.	.	.
cord-015021-pol2qm74	5387	1	Therefore	therefore	RB
cord-015021-pol2qm74	5387	2	measurement	measurement	NN
cord-015021-pol2qm74	5387	3	of	of	IN
cord-015021-pol2qm74	5387	4	cytokines	cytokine	NNS
cord-015021-pol2qm74	5387	5	and	and	CC
cord-015021-pol2qm74	5387	6	their	-PRON-	PRP$
cord-015021-pol2qm74	5387	7	potential	potential	JJ
cord-015021-pol2qm74	5387	8	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5387	9	in	in	IN
cord-015021-pol2qm74	5387	10	biological	biological	JJ
cord-015021-pol2qm74	5387	11	fluids	fluid	NNS
cord-015021-pol2qm74	5387	12	may	may	MD
cord-015021-pol2qm74	5387	13	be	be	VB
cord-015021-pol2qm74	5387	14	helpful	helpful	JJ
cord-015021-pol2qm74	5387	15	in	in	IN
cord-015021-pol2qm74	5387	16	diagnosing	diagnose	VBG
cord-015021-pol2qm74	5387	17	and	and	CC
cord-015021-pol2qm74	5387	18	monitoring	monitoring	NN
cord-015021-pol2qm74	5387	19	of	of	IN
cord-015021-pol2qm74	5387	20	diseases	disease	NNS
cord-015021-pol2qm74	5387	21	.	.	.
cord-015021-pol2qm74	5388	1	However	however	RB
cord-015021-pol2qm74	5388	2	,	,	,
cord-015021-pol2qm74	5388	3	dependent	dependent	JJ
cord-015021-pol2qm74	5388	4	on	on	IN
cord-015021-pol2qm74	5388	5	the	the	DT
cord-015021-pol2qm74	5388	6	type	type	NN
cord-015021-pol2qm74	5388	7	of	of	IN
cord-015021-pol2qm74	5388	8	assay	assay	NN
cord-015021-pol2qm74	5388	9	used	use	VBN
cord-015021-pol2qm74	5388	10	investigations	investigation	NNS
cord-015021-pol2qm74	5388	11	performed	perform	VBN
cord-015021-pol2qm74	5388	12	in	in	IN
cord-015021-pol2qm74	5388	13	different	different	JJ
cord-015021-pol2qm74	5388	14	laboratories	laboratory	NNS
cord-015021-pol2qm74	5388	15	have	have	VBP
cord-015021-pol2qm74	5388	16	often	often	RB
cord-015021-pol2qm74	5388	17	yielded	yield	VBN
cord-015021-pol2qm74	5388	18	conflicting	conflicting	JJ
cord-015021-pol2qm74	5388	19	results	result	NNS
cord-015021-pol2qm74	5388	20	.	.	.
cord-015021-pol2qm74	5389	1	In	in	IN
cord-015021-pol2qm74	5389	2	order	order	NN
cord-015021-pol2qm74	5389	3	to	to	TO
cord-015021-pol2qm74	5389	4	assess	assess	VB
cord-015021-pol2qm74	5389	5	reliability	reliability	NN
cord-015021-pol2qm74	5389	6	and	and	CC
cord-015021-pol2qm74	5389	7	reproducibility	reproducibility	NN
cord-015021-pol2qm74	5389	8	of	of	IN
cord-015021-pol2qm74	5389	9	cytokine	cytokine	NN
cord-015021-pol2qm74	5389	10	measurements	measurement	NNS
cord-015021-pol2qm74	5389	11	two	two	CD
cord-015021-pol2qm74	5389	12	comparative	comparative	JJ
cord-015021-pol2qm74	5389	13	studies	study	NNS
cord-015021-pol2qm74	5389	14	for	for	IN
cord-015021-pol2qm74	5389	15	the	the	DT
cord-015021-pol2qm74	5389	16	determination	determination	NN
cord-015021-pol2qm74	5389	17	of	of	IN
cord-015021-pol2qm74	5389	18	cytokines	cytokine	NNS
cord-015021-pol2qm74	5389	19	in	in	IN
cord-015021-pol2qm74	5389	20	biological	biological	JJ
cord-015021-pol2qm74	5389	21	fluids	fluid	NNS
cord-015021-pol2qm74	5389	22	were	be	VBD
cord-015021-pol2qm74	5389	23	launched	launch	VBN
cord-015021-pol2qm74	5389	24	by	by	IN
cord-015021-pol2qm74	5389	25	several	several	JJ
cord-015021-pol2qm74	5389	26	investigators	investigator	NNS
cord-015021-pol2qm74	5389	27	interested	interested	JJ
cord-015021-pol2qm74	5389	28	in	in	IN
cord-015021-pol2qm74	5389	29	this	this	DT
cord-015021-pol2qm74	5389	30	field	field	NN
cord-015021-pol2qm74	5389	31	:	:	:
cord-015021-pol2qm74	5390	1	one	one	CD
cord-015021-pol2qm74	5390	2	national	national	JJ
cord-015021-pol2qm74	5390	3	Austrian	Austrian	NNP
cord-015021-pol2qm74	5390	4	~tudy	~tudy	NNP
cord-015021-pol2qm74	5390	5	and	and	CC
cord-015021-pol2qm74	5390	6	one	one	CD
cord-015021-pol2qm74	5390	7	European	european	JJ
cord-015021-pol2qm74	5390	8	study	study	NN
cord-015021-pol2qm74	5390	9	in	in	IN
cord-015021-pol2qm74	5390	10	the	the	DT
cord-015021-pol2qm74	5390	11	context	context	NN
cord-015021-pol2qm74	5390	12	of	of	IN
cord-015021-pol2qm74	5390	13	the	the	DT
cord-015021-pol2qm74	5390	14	European	European	NNP
cord-015021-pol2qm74	5390	15	Workshop	Workshop	NNP
cord-015021-pol2qm74	5390	16	for	for	IN
cord-015021-pol2qm74	5390	17	Rheumatnlogy	Rheumatnlogy	NNP
cord-015021-pol2qm74	5390	18	Research	Research	NNP
cord-015021-pol2qm74	5390	19	.	.	.
cord-015021-pol2qm74	5391	1	Serum	serum	NN
cord-015021-pol2qm74	5391	2	and	and	CC
cord-015021-pol2qm74	5391	3	synovial	synovial	JJ
cord-015021-pol2qm74	5391	4	fluid	fluid	JJ
cord-015021-pol2qm74	5391	5	samples	sample	NNS
cord-015021-pol2qm74	5391	6	were	be	VBD
cord-015021-pol2qm74	5391	7	distributed	distribute	VBN
cord-015021-pol2qm74	5391	8	by	by	IN
cord-015021-pol2qm74	5391	9	the	the	DT
cord-015021-pol2qm74	5391	10	organisers	organiser	NNS
cord-015021-pol2qm74	5391	11	,	,	,
cord-015021-pol2qm74	5391	12	and	and	CC
cord-015021-pol2qm74	5391	13	participants	participant	NNS
cord-015021-pol2qm74	5391	14	had	have	VBD
cord-015021-pol2qm74	5391	15	to	to	TO
cord-015021-pol2qm74	5391	16	measure	measure	VB
cord-015021-pol2qm74	5391	17	one	one	CD
cord-015021-pol2qm74	5391	18	or	or	CC
cord-015021-pol2qm74	5391	19	several	several	JJ
cord-015021-pol2qm74	5391	20	of	of	IN
cord-015021-pol2qm74	5391	21	the	the	DT
cord-015021-pol2qm74	5391	22	following	follow	VBG
cord-015021-pol2qm74	5391	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	5391	24	in	in	IN
cord-015021-pol2qm74	5391	25	all	all	DT
cord-015021-pol2qm74	5391	26	samples	sample	NNS
cord-015021-pol2qm74	5391	27	:	:	:
cord-015021-pol2qm74	5392	1	IL-1	IL-1	NNP
cord-015021-pol2qm74	5392	2	,	,	,
cord-015021-pol2qm74	5392	3	IL-2	IL-2	NNP
cord-015021-pol2qm74	5392	4	,	,	,
cord-015021-pol2qm74	5392	5	1L-6	1l-6	CD
cord-015021-pol2qm74	5392	6	,	,	,
cord-015021-pol2qm74	5393	1	I58	I58	NNP
cord-015021-pol2qm74	5393	2	,	,	,
cord-015021-pol2qm74	5393	3	TNF	tnf	NN
cord-015021-pol2qm74	5393	4	-	-	HYPH
cord-015021-pol2qm74	5393	5	alpha	alpha	NN
cord-015021-pol2qm74	5393	6	,	,	,
cord-015021-pol2qm74	5393	7	IFN	IFN	NNP
cord-015021-pol2qm74	5393	8	-	-	HYPH
cord-015021-pol2qm74	5393	9	gamma	gamma	NN
cord-015021-pol2qm74	5393	10	,	,	,
cord-015021-pol2qm74	5393	11	GM	GM	NNP
cord-015021-pol2qm74	5393	12	-	-	HYPH
cord-015021-pol2qm74	5393	13	CSF	CSF	NNP
cord-015021-pol2qm74	5393	14	,	,	,
cord-015021-pol2qm74	5393	15	and	and	CC
cord-015021-pol2qm74	5393	16	the	the	DT
cord-015021-pol2qm74	5393	17	soluble	soluble	JJ
cord-015021-pol2qm74	5393	18	receptors	receptor	NNS
cord-015021-pol2qm74	5393	19	for	for	IN
cord-015021-pol2qm74	5393	20	IL-2	IL-2	NNP
cord-015021-pol2qm74	5393	21	and	and	CC
cord-015021-pol2qm74	5393	22	TNF	TNF	NNP
cord-015021-pol2qm74	5393	23	;	;	:
cord-015021-pol2qm74	5393	24	both	both	DT
cord-015021-pol2qm74	5393	25	commercially	commercially	RB
cord-015021-pol2qm74	5393	26	available	available	JJ
cord-015021-pol2qm74	5393	27	immunoassays	immunoassay	NNS
cord-015021-pol2qm74	5393	28	and	and	CC
cord-015021-pol2qm74	5393	29	home	home	NN
cord-015021-pol2qm74	5393	30	-	-	HYPH
cord-015021-pol2qm74	5393	31	made	make	VBN
cord-015021-pol2qm74	5393	32	assays	assay	NNS
cord-015021-pol2qm74	5393	33	were	be	VBD
cord-015021-pol2qm74	5393	34	allowed	allow	VBN
cord-015021-pol2qm74	5393	35	.	.	.
cord-015021-pol2qm74	5394	1	So	so	RB
cord-015021-pol2qm74	5394	2	far	far	RB
cord-015021-pol2qm74	5394	3	,	,	,
cord-015021-pol2qm74	5394	4	the	the	DT
cord-015021-pol2qm74	5394	5	main	main	JJ
cord-015021-pol2qm74	5394	6	conclusions	conclusion	NNS
cord-015021-pol2qm74	5394	7	emerging	emerge	VBG
cord-015021-pol2qm74	5394	8	from	from	IN
cord-015021-pol2qm74	5394	9	these	these	DT
cord-015021-pol2qm74	5394	10	preliminary	preliminary	JJ
cord-015021-pol2qm74	5394	11	studies	study	NNS
cord-015021-pol2qm74	5394	12	are	be	VBP
cord-015021-pol2qm74	5394	13	:	:	:
cord-015021-pol2qm74	5394	14	(	(	-LRB-
cord-015021-pol2qm74	5394	15	1	1	LS
cord-015021-pol2qm74	5394	16	)	)	-RRB-
cord-015021-pol2qm74	5394	17	the	the	DT
cord-015021-pol2qm74	5394	18	same	same	JJ
cord-015021-pol2qm74	5394	19	immurzoassay	immurzoassay	NNP
cord-015021-pol2qm74	5394	20	(	(	-LRB-
cord-015021-pol2qm74	5394	21	ELISA	ELISA	NNP
cord-015021-pol2qm74	5394	22	)	)	-RRB-
cord-015021-pol2qm74	5394	23	yielded	yield	VBD
cord-015021-pol2qm74	5394	24	comparable	comparable	JJ
cord-015021-pol2qm74	5394	25	results	result	NNS
cord-015021-pol2qm74	5394	26	in	in	IN
cord-015021-pol2qm74	5394	27	different	different	JJ
cord-015021-pol2qm74	5394	28	laboratories	laboratory	NNS
cord-015021-pol2qm74	5395	1	;	;	:
cord-015021-pol2qm74	5395	2	(	(	-LRB-
cord-015021-pol2qm74	5395	3	2	2	LS
cord-015021-pol2qm74	5395	4	)	)	-RRB-
cord-015021-pol2qm74	5395	5	immunoassays	immunoassay	NNS
cord-015021-pol2qm74	5395	6	from	from	IN
cord-015021-pol2qm74	5395	7	different	different	JJ
cord-015021-pol2qm74	5395	8	manufactureres	manufacturere	NNS
cord-015021-pol2qm74	5395	9	usually	usually	RB
cord-015021-pol2qm74	5395	10	measured	measure	VBD
cord-015021-pol2qm74	5395	11	the	the	DT
cord-015021-pol2qm74	5395	12	highest	high	JJS
cord-015021-pol2qm74	5395	13	concentrations	concentration	NNS
cord-015021-pol2qm74	5395	14	in	in	IN
cord-015021-pol2qm74	5395	15	the	the	DT
cord-015021-pol2qm74	5395	16	same	same	JJ
cord-015021-pol2qm74	5395	17	samples	sample	NNS
cord-015021-pol2qm74	5395	18	,	,	,
cord-015021-pol2qm74	5395	19	yielded	yield	VBD
cord-015021-pol2qm74	5395	20	similar	similar	JJ
cord-015021-pol2qm74	5395	21	relative	relative	JJ
cord-015021-pol2qm74	5395	22	values	value	NNS
cord-015021-pol2qm74	5395	23	but	but	CC
cord-015021-pol2qm74	5395	24	disparate	disparate	JJ
cord-015021-pol2qm74	5395	25	absolute	absolute	JJ
cord-015021-pol2qm74	5395	26	values	value	NNS
cord-015021-pol2qm74	5395	27	;	;	,
cord-015021-pol2qm74	5395	28	(	(	-LRB-
cord-015021-pol2qm74	5395	29	3	3	LS
cord-015021-pol2qm74	5395	30	)	)	-RRB-
cord-015021-pol2qm74	5395	31	assays	assay	NNS
cord-015021-pol2qm74	5395	32	for	for	IN
cord-015021-pol2qm74	5395	33	soluble	soluble	JJ
cord-015021-pol2qm74	5395	34	receptors	receptor	NNS
cord-015021-pol2qm74	5395	35	yielded	yield	VBD
cord-015021-pol2qm74	5395	36	less	less	RBR
cord-015021-pol2qm74	5395	37	discrepant	discrepant	JJ
cord-015021-pol2qm74	5395	38	results	result	NNS
cord-015021-pol2qm74	5395	39	;	;	,
cord-015021-pol2qm74	5395	40	(	(	-LRB-
cord-015021-pol2qm74	5395	41	4	4	LS
cord-015021-pol2qm74	5395	42	)	)	-RRB-
cord-015021-pol2qm74	5395	43	some	some	DT
cord-015021-pol2qm74	5395	44	assays	assay	NNS
cord-015021-pol2qm74	5395	45	seem	seem	VBP
cord-015021-pol2qm74	5395	46	to	to	TO
cord-015021-pol2qm74	5395	47	be	be	VB
cord-015021-pol2qm74	5395	48	more	more	RBR
cord-015021-pol2qm74	5395	49	suitable	suitable	JJ
cord-015021-pol2qm74	5395	50	for	for	IN
cord-015021-pol2qm74	5395	51	measuring	measure	VBG
cord-015021-pol2qm74	5395	52	cytokines	cytokine	NNS
cord-015021-pol2qm74	5395	53	in	in	IN
cord-015021-pol2qm74	5395	54	biological	biological	JJ
cord-015021-pol2qm74	5395	55	fluids	fluid	NNS
cord-015021-pol2qm74	5395	56	than	than	IN
cord-015021-pol2qm74	5395	57	others	other	NNS
cord-015021-pol2qm74	5395	58	.	.	.
cord-015021-pol2qm74	5396	1	The	the	DT
cord-015021-pol2qm74	5396	2	mean	mean	JJ
cord-015021-pol2qm74	5396	3	retrieval	retrieval	NN
cord-015021-pol2qm74	5396	4	of	of	IN
cord-015021-pol2qm74	5396	5	exogenous	exogenous	JJ
cord-015021-pol2qm74	5396	6	recombinant	recombinant	JJ
cord-015021-pol2qm74	5396	7	human	human	JJ
cord-015021-pol2qm74	5396	8	cytokines	cytokine	NNS
cord-015021-pol2qm74	5396	9	was	be	VBD
cord-015021-pol2qm74	5396	10	approximately	approximately	RB
cord-015021-pol2qm74	5396	11	50	50	CD
cord-015021-pol2qm74	5396	12	%	%	NN
cord-015021-pol2qm74	5396	13	for	for	IN
cord-015021-pol2qm74	5396	14	most	most	JJS
cord-015021-pol2qm74	5396	15	cytokines	cytokine	NNS
cord-015021-pol2qm74	5396	16	tested	test	VBN
cord-015021-pol2qm74	5396	17	.	.	.
cord-015021-pol2qm74	5397	1	However	however	RB
cord-015021-pol2qm74	5397	2	,	,	,
cord-015021-pol2qm74	5397	3	it	-PRON-	PRP
cord-015021-pol2qm74	5397	4	must	must	MD
cord-015021-pol2qm74	5397	5	be	be	VB
cord-015021-pol2qm74	5397	6	borne	bear	VBN
cord-015021-pol2qm74	5397	7	in	in	IN
cord-015021-pol2qm74	5397	8	mind	mind	NN
cord-015021-pol2qm74	5397	9	that	that	IN
cord-015021-pol2qm74	5397	10	natural	natural	JJ
cord-015021-pol2qm74	5397	11	and	and	CC
cord-015021-pol2qm74	5397	12	recombinant	recombinant	JJ
cord-015021-pol2qm74	5397	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	5397	14	may	may	MD
cord-015021-pol2qm74	5397	15	behave	behave	VB
cord-015021-pol2qm74	5397	16	differently	differently	RB
cord-015021-pol2qm74	5397	17	in	in	IN
cord-015021-pol2qm74	5397	18	immunoassays	immunoassays	NNP
cord-015021-pol2qm74	5397	19	.	.	.
cord-015021-pol2qm74	5398	1	This	this	DT
cord-015021-pol2qm74	5398	2	raises	raise	VBZ
cord-015021-pol2qm74	5398	3	the	the	DT
cord-015021-pol2qm74	5398	4	question	question	NN
cord-015021-pol2qm74	5398	5	as	as	IN
cord-015021-pol2qm74	5398	6	to	to	IN
cord-015021-pol2qm74	5398	7	the	the	DT
cord-015021-pol2qm74	5398	8	necessity	necessity	NN
cord-015021-pol2qm74	5398	9	of	of	IN
cord-015021-pol2qm74	5398	10	setting	set	VBG
cord-015021-pol2qm74	5398	11	up	up	RP
cord-015021-pol2qm74	5398	12	international	international	JJ
cord-015021-pol2qm74	5398	13	standards	standard	NNS
cord-015021-pol2qm74	5398	14	for	for	IN
cord-015021-pol2qm74	5398	15	all	all	DT
cord-015021-pol2qm74	5398	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	5398	17	.	.	.
cord-015021-pol2qm74	5399	1	Possible	possible	JJ
cord-015021-pol2qm74	5399	2	interferences	interference	NNS
cord-015021-pol2qm74	5399	3	by	by	IN
cord-015021-pol2qm74	5399	4	serum	serum	NN
cord-015021-pol2qm74	5399	5	components	component	NNS
cord-015021-pol2qm74	5399	6	such	such	JJ
cord-015021-pol2qm74	5399	7	as	as	IN
cord-015021-pol2qm74	5399	8	(	(	-LRB-
cord-015021-pol2qm74	5399	9	lipo)proteins	lipo)proteins	NNP
cord-015021-pol2qm74	5399	10	,	,	,
cord-015021-pol2qm74	5399	11	complement	complement	NN
cord-015021-pol2qm74	5399	12	,	,	,
cord-015021-pol2qm74	5399	13	rheumatoid	rheumatoid	NN
cord-015021-pol2qm74	5399	14	factors	factor	NNS
cord-015021-pol2qm74	5399	15	,	,	,
cord-015021-pol2qm74	5399	16	etc	etc	FW
cord-015021-pol2qm74	5399	17	.	.	FW
cord-015021-pol2qm74	5399	18	,	,	,
cord-015021-pol2qm74	5399	19	which	which	WDT
cord-015021-pol2qm74	5399	20	may	may	MD
cord-015021-pol2qm74	5399	21	either	either	CC
cord-015021-pol2qm74	5399	22	decrease	decrease	VB
cord-015021-pol2qm74	5399	23	assay	assay	NN
cord-015021-pol2qm74	5399	24	sensitivity	sensitivity	NN
cord-015021-pol2qm74	5399	25	or	or	CC
cord-015021-pol2qm74	5399	26	yield	yield	VB
cord-015021-pol2qm74	5399	27	false	false	JJ
cord-015021-pol2qm74	5399	28	positive	positive	JJ
cord-015021-pol2qm74	5399	29	results	result	NNS
cord-015021-pol2qm74	5399	30	,	,	,
cord-015021-pol2qm74	5399	31	must	must	MD
cord-015021-pol2qm74	5399	32	also	also	RB
cord-015021-pol2qm74	5399	33	be	be	VB
cord-015021-pol2qm74	5399	34	considered	consider	VBN
cord-015021-pol2qm74	5399	35	.	.	.
cord-015021-pol2qm74	5400	1	In	in	IN
cord-015021-pol2qm74	5400	2	addition	addition	NN
cord-015021-pol2qm74	5400	3	,	,	,
cord-015021-pol2qm74	5400	4	natural	natural	JJ
cord-015021-pol2qm74	5400	5	cytokine	cytokine	NN
cord-015021-pol2qm74	5400	6	binding	bind	VBG
cord-015021-pol2qm74	5400	7	proteins	protein	NNS
cord-015021-pol2qm74	5400	8	(	(	-LRB-
cord-015021-pol2qm74	5400	9	e.g.	e.g.	IN
cord-015021-pol2qm74	5400	10	soluble	soluble	JJ
cord-015021-pol2qm74	5400	11	receptors	receptor	NNS
cord-015021-pol2qm74	5400	12	)	)	-RRB-
cord-015021-pol2qm74	5400	13	might	may	MD
cord-015021-pol2qm74	5400	14	interfere	interfere	VB
cord-015021-pol2qm74	5400	15	with	with	IN
cord-015021-pol2qm74	5400	16	cytokine	cytokine	JJ
cord-015021-pol2qm74	5400	17	determination	determination	NN
cord-015021-pol2qm74	5400	18	in	in	IN
cord-015021-pol2qm74	5400	19	immunoassays	immunoassays	NNP
cord-015021-pol2qm74	5400	20	.	.	.
cord-015021-pol2qm74	5401	1	The	the	DT
cord-015021-pol2qm74	5401	2	problem	problem	NN
cord-015021-pol2qm74	5401	3	of	of	IN
cord-015021-pol2qm74	5401	4	immunoassays	immunoassays	NNP
cord-015021-pol2qm74	5401	5	versus	versus	IN
cord-015021-pol2qm74	5401	6	bioassays	bioassays	NNP
cord-015021-pol2qm74	5401	7	has	have	VBZ
cord-015021-pol2qm74	5401	8	not	not	RB
cord-015021-pol2qm74	5401	9	yet	yet	RB
cord-015021-pol2qm74	5401	10	been	be	VBN
cord-015021-pol2qm74	5401	11	approached	approach	VBN
cord-015021-pol2qm74	5401	12	,	,	,
cord-015021-pol2qm74	5401	13	but	but	CC
cord-015021-pol2qm74	5401	14	is	be	VBZ
cord-015021-pol2qm74	5401	15	without	without	IN
cord-015021-pol2qm74	5401	16	any	any	DT
cord-015021-pol2qm74	5401	17	doubt	doubt	NN
cord-015021-pol2qm74	5401	18	worth	worth	JJ
cord-015021-pol2qm74	5401	19	indepth	indepth	JJ
cord-015021-pol2qm74	5401	20	investigation	investigation	NN
cord-015021-pol2qm74	5401	21	.	.	.
cord-015021-pol2qm74	5402	1	Thus	thus	RB
cord-015021-pol2qm74	5402	2	,	,	,
cord-015021-pol2qm74	5402	3	these	these	DT
cord-015021-pol2qm74	5402	4	studies	study	NNS
cord-015021-pol2qm74	5402	5	are	be	VBP
cord-015021-pol2qm74	5402	6	a	a	DT
cord-015021-pol2qm74	5402	7	promising	promising	JJ
cord-015021-pol2qm74	5402	8	first	first	JJ
cord-015021-pol2qm74	5402	9	approach	approach	NN
cord-015021-pol2qm74	5402	10	to	to	TO
cord-015021-pol2qm74	5402	11	deal	deal	VB
cord-015021-pol2qm74	5402	12	with	with	IN
cord-015021-pol2qm74	5402	13	the	the	DT
cord-015021-pol2qm74	5402	14	difficulties	difficulty	NNS
cord-015021-pol2qm74	5402	15	of	of	IN
cord-015021-pol2qm74	5402	16	cytokine	cytokine	NN
cord-015021-pol2qm74	5402	17	analysis	analysis	NN
cord-015021-pol2qm74	5402	18	in	in	IN
cord-015021-pol2qm74	5402	19	biological	biological	JJ
cord-015021-pol2qm74	5402	20	samples	sample	NNS
cord-015021-pol2qm74	5402	21	,	,	,
cord-015021-pol2qm74	5402	22	and	and	CC
cord-015021-pol2qm74	5402	23	it	-PRON-	PRP
cord-015021-pol2qm74	5402	24	is	be	VBZ
cord-015021-pol2qm74	5402	25	hoped	hope	VBN
cord-015021-pol2qm74	5402	26	that	that	IN
cord-015021-pol2qm74	5402	27	they	-PRON-	PRP
cord-015021-pol2qm74	5402	28	will	will	MD
cord-015021-pol2qm74	5402	29	help	help	VB
cord-015021-pol2qm74	5402	30	to	to	TO
cord-015021-pol2qm74	5402	31	overcome	overcome	VB
cord-015021-pol2qm74	5402	32	some	some	DT
cord-015021-pol2qm74	5402	33	of	of	IN
cord-015021-pol2qm74	5402	34	the	the	DT
cord-015021-pol2qm74	5402	35	major	major	JJ
cord-015021-pol2qm74	5402	36	methodological	methodological	JJ
cord-015021-pol2qm74	5402	37	problems	problem	NNS
cord-015021-pol2qm74	5402	38	in	in	IN
cord-015021-pol2qm74	5402	39	the	the	DT
cord-015021-pol2qm74	5402	40	near	near	JJ
cord-015021-pol2qm74	5402	41	future	future	NN
cord-015021-pol2qm74	5402	42	.	.	.
cord-015021-pol2qm74	5403	1	Tumor	tumor	NN
cord-015021-pol2qm74	5403	2	necrosis	necrosis	NN
cord-015021-pol2qm74	5403	3	factor	factor	NN
cord-015021-pol2qm74	5403	4	(	(	-LRB-
cord-015021-pol2qm74	5403	5	TNF	TNF	NNP
cord-015021-pol2qm74	5403	6	)	)	-RRB-
cord-015021-pol2qm74	5403	7	is	be	VBZ
cord-015021-pol2qm74	5403	8	a	a	DT
cord-015021-pol2qm74	5403	9	pleiotropic	pleiotropic	JJ
cord-015021-pol2qm74	5403	10	cytokine	cytokine	NN
cord-015021-pol2qm74	5403	11	which	which	WDT
cord-015021-pol2qm74	5403	12	plays	play	VBZ
cord-015021-pol2qm74	5403	13	a	a	DT
cord-015021-pol2qm74	5403	14	key	key	JJ
cord-015021-pol2qm74	5403	15	role	role	NN
cord-015021-pol2qm74	5403	16	in	in	IN
cord-015021-pol2qm74	5403	17	a	a	DT
cord-015021-pol2qm74	5403	18	number	number	NN
cord-015021-pol2qm74	5403	19	of	of	IN
cord-015021-pol2qm74	5403	20	immunologically	immunologically	RB
cord-015021-pol2qm74	5403	21	mediated	mediate	VBN
cord-015021-pol2qm74	5403	22	disorders	disorder	NNS
cord-015021-pol2qm74	5403	23	like	like	IN
cord-015021-pol2qm74	5403	24	septicemia	septicemia	NN
cord-015021-pol2qm74	5403	25	or	or	CC
cord-015021-pol2qm74	5403	26	cachexia	cachexia	NN
cord-015021-pol2qm74	5403	27	.	.	.
cord-015021-pol2qm74	5404	1	TNF	TNF	NNP
cord-015021-pol2qm74	5404	2	receptors	receptor	NNS
cord-015021-pol2qm74	5404	3	are	be	VBP
cord-015021-pol2qm74	5404	4	found	find	VBN
cord-015021-pol2qm74	5404	5	on	on	IN
cord-015021-pol2qm74	5404	6	the	the	DT
cord-015021-pol2qm74	5404	7	surface	surface	NN
cord-015021-pol2qm74	5404	8	of	of	IN
cord-015021-pol2qm74	5404	9	a	a	DT
cord-015021-pol2qm74	5404	10	variety	variety	NN
cord-015021-pol2qm74	5404	11	of	of	IN
cord-015021-pol2qm74	5404	12	cells	cell	NNS
cord-015021-pol2qm74	5404	13	,	,	,
cord-015021-pol2qm74	5404	14	where	where	WRB
cord-015021-pol2qm74	5404	15	they	-PRON-	PRP
cord-015021-pol2qm74	5404	16	provide	provide	VBP
cord-015021-pol2qm74	5404	17	molecular	molecular	JJ
cord-015021-pol2qm74	5404	18	signals	signal	NNS
cord-015021-pol2qm74	5404	19	for	for	IN
cord-015021-pol2qm74	5404	20	the	the	DT
cord-015021-pol2qm74	5404	21	cytokine	cytokine	NN
cord-015021-pol2qm74	5404	22	effect	effect	NN
cord-015021-pol2qm74	5404	23	.	.	.
cord-015021-pol2qm74	5405	1	There	there	EX
cord-015021-pol2qm74	5405	2	exist	exist	VBP
cord-015021-pol2qm74	5405	3	two	two	CD
cord-015021-pol2qm74	5405	4	types	type	NNS
cord-015021-pol2qm74	5405	5	of	of	IN
cord-015021-pol2qm74	5405	6	soluble	soluble	JJ
cord-015021-pol2qm74	5405	7	TNF	TNF	NNP
cord-015021-pol2qm74	5405	8	receptors	receptor	NNS
cord-015021-pol2qm74	5405	9	(	(	-LRB-
cord-015021-pol2qm74	5405	10	sTNF	stnf	NN
cord-015021-pol2qm74	5405	11	-	-	HYPH
cord-015021-pol2qm74	5405	12	Rs	r	NNS
cord-015021-pol2qm74	5405	13	)	)	-RRB-
cord-015021-pol2qm74	5405	14	,	,	,
cord-015021-pol2qm74	5405	15	TNF	TNF	NNP
cord-015021-pol2qm74	5405	16	-	-	HYPH
cord-015021-pol2qm74	5405	17	R	R	NNP
cord-015021-pol2qm74	5405	18	p55	p55	NN
cord-015021-pol2qm74	5405	19	and	and	CC
cord-015021-pol2qm74	5405	20	TNF	TNF	NNP
cord-015021-pol2qm74	5405	21	-	-	HYPH
cord-015021-pol2qm74	5405	22	R	R	NNP
cord-015021-pol2qm74	5405	23	p75	p75	NN
cord-015021-pol2qm74	5405	24	.	.	.
cord-015021-pol2qm74	5406	1	These	these	DT
cord-015021-pol2qm74	5406	2	sTNF	stnf	NN
cord-015021-pol2qm74	5406	3	-	-	HYPH
cord-015021-pol2qm74	5406	4	Rs	r	NNS
cord-015021-pol2qm74	5406	5	can	can	MD
cord-015021-pol2qm74	5406	6	compete	compete	VB
cord-015021-pol2qm74	5406	7	with	with	IN
cord-015021-pol2qm74	5406	8	the	the	DT
cord-015021-pol2qm74	5406	9	cell	cell	NN
cord-015021-pol2qm74	5406	10	surface	surface	NN
cord-015021-pol2qm74	5406	11	receptors	receptor	NNS
cord-015021-pol2qm74	5406	12	and	and	CC
cord-015021-pol2qm74	5406	13	block	block	VB
cord-015021-pol2qm74	5406	14	their	-PRON-	PRP$
cord-015021-pol2qm74	5406	15	activity	activity	NN
cord-015021-pol2qm74	5406	16	.	.	.
cord-015021-pol2qm74	5407	1	The	the	DT
cord-015021-pol2qm74	5407	2	expression	expression	NN
cord-015021-pol2qm74	5407	3	on	on	IN
cord-015021-pol2qm74	5407	4	and	and	CC
cord-015021-pol2qm74	5407	5	shedding	shed	VBG
cord-015021-pol2qm74	5407	6	from	from	IN
cord-015021-pol2qm74	5407	7	the	the	DT
cord-015021-pol2qm74	5407	8	cell	cell	NN
cord-015021-pol2qm74	5407	9	surface	surface	NN
cord-015021-pol2qm74	5407	10	of	of	IN
cord-015021-pol2qm74	5407	11	sTNF	stnf	NN
cord-015021-pol2qm74	5407	12	-	-	HYPH
cord-015021-pol2qm74	5407	13	Rs	rs	NN
cord-015021-pol2qm74	5407	14	is	be	VBZ
cord-015021-pol2qm74	5407	15	enhanced	enhance	VBN
cord-015021-pol2qm74	5407	16	by	by	IN
cord-015021-pol2qm74	5407	17	interferon	interferon	NN
cord-015021-pol2qm74	5407	18	gamma	gamma	NN
cord-015021-pol2qm74	5407	19	.	.	.
cord-015021-pol2qm74	5408	1	Increased	increase	VBN
cord-015021-pol2qm74	5408	2	concentrations	concentration	NNS
cord-015021-pol2qm74	5408	3	of	of	IN
cord-015021-pol2qm74	5408	4	sTNF	stnf	NN
cord-015021-pol2qm74	5408	5	-	-	HYPH
cord-015021-pol2qm74	5408	6	Rs	r	NNS
cord-015021-pol2qm74	5408	7	can	can	MD
cord-015021-pol2qm74	5408	8	be	be	VB
cord-015021-pol2qm74	5408	9	found	find	VBN
cord-015021-pol2qm74	5408	10	in	in	IN
cord-015021-pol2qm74	5408	11	patients	patient	NNS
cord-015021-pol2qm74	5408	12	with	with	IN
cord-015021-pol2qm74	5408	13	infectious	infectious	JJ
cord-015021-pol2qm74	5408	14	as	as	RB
cord-015021-pol2qm74	5408	15	well	well	RB
cord-015021-pol2qm74	5408	16	as	as	IN
cord-015021-pol2qm74	5408	17	malignant	malignant	JJ
cord-015021-pol2qm74	5408	18	disorders	disorder	NNS
cord-015021-pol2qm74	5408	19	.	.	.
cord-015021-pol2qm74	5409	1	In	in	IN
cord-015021-pol2qm74	5409	2	patients	patient	NNS
cord-015021-pol2qm74	5409	3	undergoing	undergo	VBG
cord-015021-pol2qm74	5409	4	immune	immune	JJ
cord-015021-pol2qm74	5409	5	stimulatory	stimulatory	JJ
cord-015021-pol2qm74	5409	6	therapy	therapy	NN
cord-015021-pol2qm74	5409	7	with	with	IN
cord-015021-pol2qm74	5409	8	interleukin-2	interleukin-2	NN
cord-015021-pol2qm74	5409	9	and	and	CC
cord-015021-pol2qm74	5409	10	interferon	interferon	NN
cord-015021-pol2qm74	5409	11	alpha	alpha	NN
cord-015021-pol2qm74	5409	12	a	a	DT
cord-015021-pol2qm74	5409	13	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	5409	14	increase	increase	NN
cord-015021-pol2qm74	5409	15	of	of	IN
cord-015021-pol2qm74	5409	16	TNF	TNF	NNP
cord-015021-pol2qm74	5409	17	and	and	CC
cord-015021-pol2qm74	5409	18	its	-PRON-	PRP$
cord-015021-pol2qm74	5409	19	soluble	soluble	JJ
cord-015021-pol2qm74	5409	20	receptors	receptor	NNS
cord-015021-pol2qm74	5409	21	can	can	MD
cord-015021-pol2qm74	5409	22	be	be	VB
cord-015021-pol2qm74	5409	23	seen	see	VBN
cord-015021-pol2qm74	5409	24	.	.	.
cord-015021-pol2qm74	5410	1	In	in	IN
cord-015021-pol2qm74	5410	2	patients	patient	NNS
cord-015021-pol2qm74	5410	3	with	with	IN
cord-015021-pol2qm74	5410	4	HIV	HIV	NNP
cord-015021-pol2qm74	5410	5	infection	infection	NN
cord-015021-pol2qm74	5410	6	a	a	DT
cord-015021-pol2qm74	5410	7	strong	strong	JJ
cord-015021-pol2qm74	5410	8	correlation	correlation	NN
cord-015021-pol2qm74	5410	9	exists	exist	VBZ
cord-015021-pol2qm74	5410	10	between	between	IN
cord-015021-pol2qm74	5410	11	the	the	DT
cord-015021-pol2qm74	5410	12	levels	level	NNS
cord-015021-pol2qm74	5410	13	of	of	IN
cord-015021-pol2qm74	5410	14	sTNF	stnf	NN
cord-015021-pol2qm74	5410	15	-	-	HYPH
cord-015021-pol2qm74	5410	16	Rs	r	NNS
cord-015021-pol2qm74	5410	17	and	and	CC
cord-015021-pol2qm74	5410	18	markers	marker	NNS
cord-015021-pol2qm74	5410	19	of	of	IN
cord-015021-pol2qm74	5410	20	immune	immune	JJ
cord-015021-pol2qm74	5410	21	activation	activation	NN
cord-015021-pol2qm74	5410	22	like	like	IN
cord-015021-pol2qm74	5410	23	neopterin	neopterin	NNP
cord-015021-pol2qm74	5410	24	or	or	CC
cord-015021-pol2qm74	5410	25	beta-2-microglobulin	beta-2-microglobulin	NNP
cord-015021-pol2qm74	5410	26	.	.	.
cord-015021-pol2qm74	5411	1	Likewise	likewise	RB
cord-015021-pol2qm74	5411	2	patients	patient	NNS
cord-015021-pol2qm74	5411	3	with	with	IN
cord-015021-pol2qm74	5411	4	hematological	hematological	JJ
cord-015021-pol2qm74	5411	5	disorders	disorder	NNS
cord-015021-pol2qm74	5411	6	show	show	VBP
cord-015021-pol2qm74	5411	7	elevated	elevated	JJ
cord-015021-pol2qm74	5411	8	sTNF	stnf	NN
cord-015021-pol2qm74	5411	9	-	-	HYPH
cord-015021-pol2qm74	5411	10	R	r	NN
cord-015021-pol2qm74	5411	11	levels	level	NNS
cord-015021-pol2qm74	5411	12	.	.	.
cord-015021-pol2qm74	5412	1	Patients	patient	NNS
cord-015021-pol2qm74	5412	2	with	with	IN
cord-015021-pol2qm74	5412	3	weight	weight	NN
cord-015021-pol2qm74	5412	4	loss	loss	NN
cord-015021-pol2qm74	5412	5	have	have	VBP
cord-015021-pol2qm74	5412	6	higher	high	JJR
cord-015021-pol2qm74	5412	7	concentrations	concentration	NNS
cord-015021-pol2qm74	5412	8	than	than	IN
cord-015021-pol2qm74	5412	9	patients	patient	NNS
cord-015021-pol2qm74	5412	10	with	with	IN
cord-015021-pol2qm74	5412	11	stable	stable	JJ
cord-015021-pol2qm74	5412	12	weight	weight	NN
cord-015021-pol2qm74	5412	13	.	.	.
cord-015021-pol2qm74	5413	1	The	the	DT
cord-015021-pol2qm74	5413	2	final	final	JJ
cord-015021-pol2qm74	5413	3	value	value	NN
cord-015021-pol2qm74	5413	4	of	of	IN
cord-015021-pol2qm74	5413	5	sTNF	stnf	NN
cord-015021-pol2qm74	5413	6	-	-	HYPH
cord-015021-pol2qm74	5413	7	Rs	r	NNS
cord-015021-pol2qm74	5413	8	within	within	IN
cord-015021-pol2qm74	5413	9	the	the	DT
cord-015021-pol2qm74	5413	10	complex	complex	JJ
cord-015021-pol2qm74	5413	11	network	network	NN
cord-015021-pol2qm74	5413	12	of	of	IN
cord-015021-pol2qm74	5413	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	5413	14	is	be	VBZ
cord-015021-pol2qm74	5413	15	not	not	RB
cord-015021-pol2qm74	5413	16	yet	yet	RB
cord-015021-pol2qm74	5413	17	clear	clear	JJ
cord-015021-pol2qm74	5413	18	.	.	.
cord-015021-pol2qm74	5414	1	However	however	RB
cord-015021-pol2qm74	5414	2	,	,	,
cord-015021-pol2qm74	5414	3	there	there	EX
cord-015021-pol2qm74	5414	4	exist	exist	VBP
cord-015021-pol2qm74	5414	5	striking	strike	VBG
cord-015021-pol2qm74	5414	6	parallels	parallel	NNS
cord-015021-pol2qm74	5414	7	between	between	IN
cord-015021-pol2qm74	5414	8	infectious	infectious	JJ
cord-015021-pol2qm74	5414	9	and	and	CC
cord-015021-pol2qm74	5414	10	malignant	malignant	JJ
cord-015021-pol2qm74	5414	11	disorders	disorder	NNS
cord-015021-pol2qm74	5414	12	pointing	point	VBG
cord-015021-pol2qm74	5414	13	to	to	IN
cord-015021-pol2qm74	5414	14	a	a	DT
cord-015021-pol2qm74	5414	15	key	key	JJ
cord-015021-pol2qm74	5414	16	role	role	NN
cord-015021-pol2qm74	5414	17	of	of	IN
cord-015021-pol2qm74	5414	18	endogenous	endogenous	JJ
cord-015021-pol2qm74	5414	19	immune	immune	JJ
cord-015021-pol2qm74	5414	20	activation	activation	NN
cord-015021-pol2qm74	5414	21	.	.	.
cord-015021-pol2qm74	5415	1	Biochemicatly	Biochemicatly	NNP
cord-015021-pol2qm74	5415	2	,	,	,
cord-015021-pol2qm74	5415	3	D	D	NNP
cord-015021-pol2qm74	5415	4	-	-	HYPH
cord-015021-pol2qm74	5415	5	erythro	erythro	JJ
cord-015021-pol2qm74	5415	6	-	-	HYPH
cord-015021-pol2qm74	5415	7	neopterin	neopterin	NN
cord-015021-pol2qm74	5415	8	derives	derive	VBZ
cord-015021-pol2qm74	5415	9	from	from	IN
cord-015021-pol2qm74	5415	10	guanosine	guanosine	NN
cord-015021-pol2qm74	5415	11	triphosphate	triphosphate	NN
cord-015021-pol2qm74	5415	12	.	.	.
cord-015021-pol2qm74	5416	1	In	in	IN
cord-015021-pol2qm74	5416	2	vitro	vitro	FW
cord-015021-pol2qm74	5416	3	studies	study	NNS
cord-015021-pol2qm74	5416	4	show	show	VBP
cord-015021-pol2qm74	5416	5	that	that	IN
cord-015021-pol2qm74	5416	6	large	large	JJ
cord-015021-pol2qm74	5416	7	amounts	amount	NNS
cord-015021-pol2qm74	5416	8	of	of	IN
cord-015021-pol2qm74	5416	9	neopterin	neopterin	NNS
cord-015021-pol2qm74	5416	10	are	be	VBP
cord-015021-pol2qm74	5416	11	produced	produce	VBN
cord-015021-pol2qm74	5416	12	by	by	IN
cord-015021-pol2qm74	5416	13	human	human	JJ
cord-015021-pol2qm74	5416	14	monocytes	monocyte	NNS
cord-015021-pol2qm74	5416	15	/	/	SYM
cord-015021-pol2qm74	5416	16	macrophages	macrophage	NNS
cord-015021-pol2qm74	5416	17	stimulated	stimulate	VBN
cord-015021-pol2qm74	5416	18	with	with	IN
cord-015021-pol2qm74	5416	19	interferon	interferon	NN
cord-015021-pol2qm74	5416	20	-	-	HYPH
cord-015021-pol2qm74	5416	21	j	j	NNP
cord-015021-pol2qm74	5416	22	(	(	-LRB-
cord-015021-pol2qm74	5416	23	IFN	IFN	NNP
cord-015021-pol2qm74	5416	24	-	-	HYPH
cord-015021-pol2qm74	5416	25	J	J	NNP
cord-015021-pol2qm74	5416	26	)	)	-RRB-
cord-015021-pol2qm74	5416	27	.	.	.
cord-015021-pol2qm74	5417	1	Neopterin	Neopterin	NNP
cord-015021-pol2qm74	5417	2	is	be	VBZ
cord-015021-pol2qm74	5417	3	biologically	biologically	RB
cord-015021-pol2qm74	5417	4	stable	stable	JJ
cord-015021-pol2qm74	5417	5	,	,	,
cord-015021-pol2qm74	5417	6	and	and	CC
cord-015021-pol2qm74	5417	7	its	-PRON-	PRP$
cord-015021-pol2qm74	5417	8	halflife	halflife	NN
cord-015021-pol2qm74	5417	9	in	in	IN
cord-015021-pol2qm74	5417	10	the	the	DT
cord-015021-pol2qm74	5417	11	blood	blood	NN
cord-015021-pol2qm74	5417	12	seems	seem	VBZ
cord-015021-pol2qm74	5417	13	to	to	TO
cord-015021-pol2qm74	5417	14	solely	solely	RB
cord-015021-pol2qm74	5417	15	depend	depend	VB
cord-015021-pol2qm74	5417	16	on	on	IN
cord-015021-pol2qm74	5417	17	renal	renal	JJ
cord-015021-pol2qm74	5417	18	excretion	excretion	NN
cord-015021-pol2qm74	5417	19	.	.	.
cord-015021-pol2qm74	5418	1	Specimen	specimen	JJ
cord-015021-pol2qm74	5418	2	for	for	IN
cord-015021-pol2qm74	5418	3	neopterin	neopterin	JJ
cord-015021-pol2qm74	5418	4	determination	determination	NN
cord-015021-pol2qm74	5418	5	can	can	MD
cord-015021-pol2qm74	5418	6	be	be	VB
cord-015021-pol2qm74	5418	7	stored	store	VBN
cord-015021-pol2qm74	5418	8	without	without	IN
cord-015021-pol2qm74	5418	9	special	special	JJ
cord-015021-pol2qm74	5418	10	precautions	precaution	NNS
cord-015021-pol2qm74	5418	11	.	.	.
cord-015021-pol2qm74	5419	1	Increased	increase	VBN
cord-015021-pol2qm74	5419	2	concentrations	concentration	NNS
cord-015021-pol2qm74	5419	3	of	of	IN
cord-015021-pol2qm74	5419	4	neopterin	neopterin	NNP
cord-015021-pol2qm74	5419	5	have	have	VBP
cord-015021-pol2qm74	5419	6	been	be	VBN
cord-015021-pol2qm74	5419	7	described	describe	VBN
cord-015021-pol2qm74	5419	8	in	in	IN
cord-015021-pol2qm74	5419	9	body	body	NN
cord-015021-pol2qm74	5419	10	fluids	fluid	NNS
cord-015021-pol2qm74	5419	11	of	of	IN
cord-015021-pol2qm74	5419	12	patients	patient	NNS
cord-015021-pol2qm74	5419	13	suffering	suffer	VBG
cord-015021-pol2qm74	5419	14	from	from	IN
cord-015021-pol2qm74	5419	15	diseases	disease	NNS
cord-015021-pol2qm74	5419	16	which	which	WDT
cord-015021-pol2qm74	5419	17	are	be	VBP
cord-015021-pol2qm74	5419	18	apparently	apparently	RB
cord-015021-pol2qm74	5419	19	associated	associate	VBN
cord-015021-pol2qm74	5419	20	with	with	IN
cord-015021-pol2qm74	5419	21	an	an	DT
cord-015021-pol2qm74	5419	22	activated	activate	VBN
cord-015021-pol2qm74	5419	23	cellular	cellular	JJ
cord-015021-pol2qm74	5419	24	immune	immune	JJ
cord-015021-pol2qm74	5419	25	response	response	NN
cord-015021-pol2qm74	5419	26	and	and	CC
cord-015021-pol2qm74	5419	27	with	with	IN
cord-015021-pol2qm74	5419	28	enhanced	enhanced	JJ
cord-015021-pol2qm74	5419	29	endogenous	endogenous	JJ
cord-015021-pol2qm74	5419	30	formation	formation	NN
cord-015021-pol2qm74	5419	31	of	of	IN
cord-015021-pol2qm74	5419	32	IFN-~	IFN-~	NNP
cord-015021-pol2qm74	5419	33	'	'	''
cord-015021-pol2qm74	5419	34	,	,	,
cord-015021-pol2qm74	5419	35	e.g	e.g	NNP
cord-015021-pol2qm74	5419	36	,	,	,
cord-015021-pol2qm74	5419	37	,	,	,
cord-015021-pol2qm74	5419	38	1	1	CD
cord-015021-pol2qm74	5419	39	)	)	-RRB-
cord-015021-pol2qm74	5419	40	increasing	increase	VBG
cord-015021-pol2qm74	5419	41	neopterin	neopterin	JJ
cord-015021-pol2qm74	5419	42	levels	level	NNS
cord-015021-pol2qm74	5419	43	predict	predict	VBP
cord-015021-pol2qm74	5419	44	rejection	rejection	NN
cord-015021-pol2qm74	5419	45	episodes	episode	NNS
cord-015021-pol2qm74	5419	46	in	in	IN
cord-015021-pol2qm74	5419	47	allograft	allograft	NN
cord-015021-pol2qm74	5419	48	recipients	recipient	NNS
cord-015021-pol2qm74	5419	49	2	2	LS
cord-015021-pol2qm74	5419	50	)	)	-RRB-
cord-015021-pol2qm74	5419	51	virus	virus	NN
cord-015021-pol2qm74	5419	52	infections	infection	NNS
cord-015021-pol2qm74	5419	53	induce	induce	VBP
cord-015021-pol2qm74	5419	54	increased	increase	VBN
cord-015021-pol2qm74	5419	55	neopterin	neopterin	JJ
cord-015021-pol2qm74	5419	56	concentrations	concentration	NNS
cord-015021-pol2qm74	5419	57	,	,	,
cord-015021-pol2qm74	5419	58	and	and	CC
cord-015021-pol2qm74	5419	59	the	the	DT
cord-015021-pol2qm74	5419	60	degree	degree	NN
cord-015021-pol2qm74	5419	61	of	of	IN
cord-015021-pol2qm74	5419	62	neopterin	neopterin	NNP
cord-015021-pol2qm74	5419	63	elevation	elevation	NNP
cord-015021-pol2qm74	5419	64	predicts	predict	VBZ
cord-015021-pol2qm74	5419	65	prognosis	prognosis	NN
cord-015021-pol2qm74	5419	66	in	in	IN
cord-015021-pol2qm74	5419	67	these	these	DT
cord-015021-pol2qm74	5419	68	patients	patient	NNS
cord-015021-pol2qm74	5419	69	which	which	WDT
cord-015021-pol2qm74	5419	70	is	be	VBZ
cord-015021-pol2qm74	5419	71	particularly	particularly	RB
cord-015021-pol2qm74	5419	72	true	true	JJ
cord-015021-pol2qm74	5419	73	in	in	IN
cord-015021-pol2qm74	5419	74	HIV-1	HIV-1	NNP
cord-015021-pol2qm74	5419	75	infection	infection	NN
cord-015021-pol2qm74	5419	76	3	3	CD
cord-015021-pol2qm74	5419	77	)	)	-RRB-
cord-015021-pol2qm74	5419	78	in	in	IN
cord-015021-pol2qm74	5419	79	autoimmune	autoimmune	JJ
cord-015021-pol2qm74	5419	80	disorders	disorder	NNS
cord-015021-pol2qm74	5419	81	such	such	JJ
cord-015021-pol2qm74	5419	82	as	as	IN
cord-015021-pol2qm74	5419	83	systemic	systemic	JJ
cord-015021-pol2qm74	5419	84	lupus	lupus	NN
cord-015021-pol2qm74	5419	85	erythematosus	erythematosus	NN
cord-015021-pol2qm74	5419	86	or	or	CC
cord-015021-pol2qm74	5419	87	rheumatoid	rheumatoid	NN
cord-015021-pol2qm74	5419	88	arthritis	arthritis	NN
cord-015021-pol2qm74	5419	89	neopterin	neopterin	NNP
cord-015021-pol2qm74	5419	90	levels	level	NNS
cord-015021-pol2qm74	5419	91	reflect	reflect	VBP
cord-015021-pol2qm74	5419	92	activity	activity	NN
cord-015021-pol2qm74	5419	93	of	of	IN
cord-015021-pol2qm74	5419	94	the	the	DT
cord-015021-pol2qm74	5419	95	disease	disease	NN
cord-015021-pol2qm74	5419	96	4	4	CD
cord-015021-pol2qm74	5419	97	)	)	-RRB-
cord-015021-pol2qm74	5419	98	increased	increase	VBD
cord-015021-pol2qm74	5419	99	neopterin	neopterin	JJ
cord-015021-pol2qm74	5419	100	concentrations	concentration	NNS
cord-015021-pol2qm74	5419	101	in	in	IN
cord-015021-pol2qm74	5419	102	patients	patient	NNS
cord-015021-pol2qm74	5419	103	suffering	suffer	VBG
cord-015021-pol2qm74	5419	104	from	from	IN
cord-015021-pol2qm74	5419	105	certain	certain	JJ
cord-015021-pol2qm74	5419	106	types	type	NNS
cord-015021-pol2qm74	5419	107	of	of	IN
cord-015021-pol2qm74	5419	108	cancer	cancer	NN
cord-015021-pol2qm74	5419	109	indicate	indicate	VBP
cord-015021-pol2qm74	5419	110	poor	poor	JJ
cord-015021-pol2qm74	5419	111	prognosis	prognosis	NN
cord-015021-pol2qm74	5419	112	.	.	.
cord-015021-pol2qm74	5420	1	Significant	significant	JJ
cord-015021-pol2qm74	5420	2	associations	association	NNS
cord-015021-pol2qm74	5420	3	between	between	IN
cord-015021-pol2qm74	5420	4	changes	change	NNS
cord-015021-pol2qm74	5420	5	of	of	IN
cord-015021-pol2qm74	5420	6	neopterin	neopterin	NN
cord-015021-pol2qm74	5420	7	and	and	CC
cord-015021-pol2qm74	5420	8	decrease	decrease	NN
cord-015021-pol2qm74	5420	9	of	of	IN
cord-015021-pol2qm74	5420	10	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	5420	11	as	as	RB
cord-015021-pol2qm74	5420	12	well	well	RB
cord-015021-pol2qm74	5420	13	as	as	IN
cord-015021-pol2qm74	5420	14	the	the	DT
cord-015021-pol2qm74	5420	15	development	development	NN
cord-015021-pol2qm74	5420	16	of	of	IN
cord-015021-pol2qm74	5420	17	weight	weight	NN
cord-015021-pol2qm74	5420	18	loss	loss	NN
cord-015021-pol2qm74	5420	19	and	and	CC
cord-015021-pol2qm74	5420	20	cachexia	cachexia	NN
cord-015021-pol2qm74	5420	21	,	,	,
cord-015021-pol2qm74	5420	22	e.g.	e.g.	RB
cord-015021-pol2qm74	5420	23	,	,	,
cord-015021-pol2qm74	5420	24	in	in	IN
cord-015021-pol2qm74	5420	25	cancer	cancer	NN
cord-015021-pol2qm74	5420	26	patients	patient	NNS
cord-015021-pol2qm74	5420	27	and	and	CC
cord-015021-pol2qm74	5420	28	in	in	IN
cord-015021-pol2qm74	5420	29	patients	patient	NNS
cord-015021-pol2qm74	5420	30	with	with	IN
cord-015021-pol2qm74	5420	31	HIV-1	HIV-1	NNP
cord-015021-pol2qm74	5420	32	infection	infection	NN
cord-015021-pol2qm74	5420	33	,	,	,
cord-015021-pol2qm74	5420	34	support	support	VB
cord-015021-pol2qm74	5420	35	the	the	DT
cord-015021-pol2qm74	5420	36	concept	concept	NN
cord-015021-pol2qm74	5420	37	that	that	WDT
cord-015021-pol2qm74	5420	38	endogenously	endogenously	RB
cord-015021-pol2qm74	5420	39	formed	form	VBD
cord-015021-pol2qm74	5420	40	cytokines	cytokine	NNS
cord-015021-pol2qm74	5420	41	such	such	JJ
cord-015021-pol2qm74	5420	42	as	as	IN
cord-015021-pol2qm74	5420	43	IFN-~	IFN-~	NNP
cord-015021-pol2qm74	5420	44	"	"	''
cord-015021-pol2qm74	5420	45	and	and	CC
cord-015021-pol2qm74	5420	46	tumor	tumor	NN
cord-015021-pol2qm74	5420	47	necrosis	necrosis	NN
cord-015021-pol2qm74	5420	48	factor-~	factor-~	NNP
cord-015021-pol2qm74	5420	49	(	(	-LRB-
cord-015021-pol2qm74	5420	50	are	be	VBP
cord-015021-pol2qm74	5420	51	involved	involve	VBN
cord-015021-pol2qm74	5420	52	in	in	IN
cord-015021-pol2qm74	5420	53	the	the	DT
cord-015021-pol2qm74	5420	54	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	5420	55	of	of	IN
cord-015021-pol2qm74	5420	56	such	such	JJ
cord-015021-pol2qm74	5420	57	symptoms	symptom	NNS
cord-015021-pol2qm74	5420	58	.	.	.
cord-015021-pol2qm74	5421	1	In	in	IN
cord-015021-pol2qm74	5421	2	conclusion	conclusion	NN
cord-015021-pol2qm74	5421	3	,	,	,
cord-015021-pol2qm74	5421	4	neopterin	neopterin	JJ
cord-015021-pol2qm74	5421	5	monitoring	monitoring	NN
cord-015021-pol2qm74	5421	6	is	be	VBZ
cord-015021-pol2qm74	5421	7	a	a	DT
cord-015021-pol2qm74	5421	8	sensitive	sensitive	JJ
cord-015021-pol2qm74	5421	9	tool	tool	NN
cord-015021-pol2qm74	5421	10	to	to	TO
cord-015021-pol2qm74	5421	11	detect	detect	VB
cord-015021-pol2qm74	5421	12	the	the	DT
cord-015021-pol2qm74	5421	13	activation	activation	NN
cord-015021-pol2qm74	5421	14	status	status	NN
cord-015021-pol2qm74	5421	15	of	of	IN
cord-015021-pol2qm74	5421	16	the	the	DT
cord-015021-pol2qm74	5421	17	cell	cell	NN
cord-015021-pol2qm74	5421	18	-	-	HYPH
cord-015021-pol2qm74	5421	19	mediated	mediate	VBN
cord-015021-pol2qm74	5421	20	immune	immune	JJ
cord-015021-pol2qm74	5421	21	system	system	NN
cord-015021-pol2qm74	5421	22	in	in	IN
cord-015021-pol2qm74	5421	23	vivo	vivo	NNP
cord-015021-pol2qm74	5421	24	.	.	.
cord-015021-pol2qm74	5422	1	Repair	repair	NN
cord-015021-pol2qm74	5422	2	and	and	CC
cord-015021-pol2qm74	5422	3	healing	healing	NN
cord-015021-pol2qm74	5422	4	or	or	CC
cord-015021-pol2qm74	5422	5	perpetuation	perpetuation	NN
cord-015021-pol2qm74	5422	6	of	of	IN
cord-015021-pol2qm74	5422	7	acute	acute	JJ
cord-015021-pol2qm74	5422	8	inflammation	inflammation	NN
cord-015021-pol2qm74	5422	9	is	be	VBZ
cord-015021-pol2qm74	5422	10	characterized	characterize	VBN
cord-015021-pol2qm74	5422	11	by	by	IN
cord-015021-pol2qm74	5422	12	a	a	DT
cord-015021-pol2qm74	5422	13	complex	complex	JJ
cord-015021-pol2qm74	5422	14	network	network	NN
cord-015021-pol2qm74	5422	15	of	of	IN
cord-015021-pol2qm74	5422	16	interacting	interact	VBG
cord-015021-pol2qm74	5422	17	cellular	cellular	JJ
cord-015021-pol2qm74	5422	18	and	and	CC
cord-015021-pol2qm74	5422	19	humoral	humoral	JJ
cord-015021-pol2qm74	5422	20	defence	defence	NN
cord-015021-pol2qm74	5422	21	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5422	22	.	.	.
cord-015021-pol2qm74	5423	1	Of	of	IN
cord-015021-pol2qm74	5423	2	the	the	DT
cord-015021-pol2qm74	5423	3	numerous	numerous	JJ
cord-015021-pol2qm74	5423	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5423	5	mediators	mediator	NNS
cord-015021-pol2qm74	5423	6	/	/	SYM
cord-015021-pol2qm74	5423	7	effectors	effector	NNS
cord-015021-pol2qm74	5423	8	investigated	investigate	VBN
cord-015021-pol2qm74	5423	9	hitherto	hitherto	VBN
cord-015021-pol2qm74	5423	10	,	,	,
cord-015021-pol2qm74	5423	11	the	the	DT
cord-015021-pol2qm74	5423	12	proteolydc	proteolydc	JJ
cord-015021-pol2qm74	5423	13	lysosomal	lysosomal	JJ
cord-015021-pol2qm74	5423	14	enzyme	enzyme	NN
cord-015021-pol2qm74	5423	15	PMN	PMN	NNP
cord-015021-pol2qm74	5423	16	elastase	elastase	NN
cord-015021-pol2qm74	5423	17	has	have	VBZ
cord-015021-pol2qm74	5423	18	turned	turn	VBN
cord-015021-pol2qm74	5423	19	out	out	RP
cord-015021-pol2qm74	5423	20	to	to	TO
cord-015021-pol2qm74	5423	21	be	be	VB
cord-015021-pol2qm74	5423	22	highly	highly	RB
cord-015021-pol2qm74	5423	23	destructive	destructive	JJ
cord-015021-pol2qm74	5423	24	when	when	WRB
cord-015021-pol2qm74	5423	25	released	release	VBN
cord-015021-pol2qm74	5423	26	extracellularly	extracellularly	RB
cord-015021-pol2qm74	5423	27	thus	thus	RB
cord-015021-pol2qm74	5423	28	contributing	contribute	VBG
cord-015021-pol2qm74	5423	29	considm	considm	NNP
cord-015021-pol2qm74	5423	30	:	:	:
cord-015021-pol2qm74	5423	31	ably	ably	RB
cord-015021-pol2qm74	5423	32	to	to	IN
cord-015021-pol2qm74	5423	33	organ	organ	NN
cord-015021-pol2qm74	5423	34	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	5423	35	in	in	IN
cord-015021-pol2qm74	5423	36	severe	severe	JJ
cord-015021-pol2qm74	5423	37	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	5423	38	and	and	CC
cord-015021-pol2qm74	5423	39	postoperative	postoperative	JJ
cord-015021-pol2qm74	5423	40	courses	course	NNS
cord-015021-pol2qm74	5423	41	.	.	.
cord-015021-pol2qm74	5424	1	Besides	besides	IN
cord-015021-pol2qm74	5424	2	various	various	JJ
cord-015021-pol2qm74	5424	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	5424	4	,	,	,
cord-015021-pol2qm74	5424	5	elastase	elastase	NN
cord-015021-pol2qm74	5424	6	in	in	IN
cord-015021-pol2qm74	5424	7	complex	complex	NN
cord-015021-pol2qm74	5424	8	with	with	IN
cord-015021-pol2qm74	5424	9	its	-PRON-	PRP$
cord-015021-pol2qm74	5424	10	main	main	JJ
cord-015021-pol2qm74	5424	11	antagonist	antagonist	NN
cord-015021-pol2qm74	5425	1	c¢	c¢	NNP
cord-015021-pol2qm74	5426	1	1-proteinase	1-proteinase	CD
cord-015021-pol2qm74	5426	2	inhibitor	inhibitor	NN
cord-015021-pol2qm74	5426	3	(	(	-LRB-
cord-015021-pol2qm74	5426	4	a	a	DT
cord-015021-pol2qm74	5426	5	1PI	1pi	CD
cord-015021-pol2qm74	5426	6	)	)	-RRB-
cord-015021-pol2qm74	5426	7	is	be	VBZ
cord-015021-pol2qm74	5426	8	also	also	RB
cord-015021-pol2qm74	5426	9	supposed	suppose	VBN
cord-015021-pol2qm74	5426	10	to	to	TO
cord-015021-pol2qm74	5426	11	induce	induce	VB
cord-015021-pol2qm74	5426	12	the	the	DT
cord-015021-pol2qm74	5426	13	shedding	shedding	NN
cord-015021-pol2qm74	5426	14	of	of	IN
cord-015021-pol2qm74	5426	15	intercellular	intercellular	JJ
cord-015021-pol2qm74	5426	16	adhesion	adhesion	NN
cord-015021-pol2qm74	5426	17	molecules	molecule	NNS
cord-015021-pol2qm74	5426	18	from	from	IN
cord-015021-pol2qm74	5426	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5426	20	cells	cell	NNS
cord-015021-pol2qm74	5426	21	(	(	-LRB-
cord-015021-pol2qm74	5426	22	PMNs	pmn	NNS
cord-015021-pol2qm74	5426	23	,	,	,
cord-015021-pol2qm74	5426	24	monocytes	monocyte	NNS
cord-015021-pol2qm74	5426	25	/	/	SYM
cord-015021-pol2qm74	5426	26	macrophages	macrophage	NNS
cord-015021-pol2qm74	5426	27	,	,	,
cord-015021-pol2qm74	5426	28	endothelial	endothelial	JJ
cord-015021-pol2qm74	5426	29	cells	cell	NNS
cord-015021-pol2qm74	5426	30	)	)	-RRB-
cord-015021-pol2qm74	5426	31	.	.	.
cord-015021-pol2qm74	5427	1	These	these	DT
cord-015021-pol2qm74	5427	2	soluble	soluble	JJ
cord-015021-pol2qm74	5427	3	adhesion	adhesion	NN
cord-015021-pol2qm74	5427	4	molecules	molecule	NNS
cord-015021-pol2qm74	5427	5	may	may	MD
cord-015021-pol2qm74	5427	6	modulate	modulate	VB
cord-015021-pol2qm74	5427	7	the	the	DT
cord-015021-pol2qm74	5427	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5427	9	process	process	NN
cord-015021-pol2qm74	5427	10	in	in	IN
cord-015021-pol2qm74	5427	11	many	many	JJ
cord-015021-pol2qm74	5427	12	different	different	JJ
cord-015021-pol2qm74	5427	13	ways	way	NNS
cord-015021-pol2qm74	5427	14	,	,	,
cord-015021-pol2qm74	5427	15	e.g.	e.g.	RB
cord-015021-pol2qm74	5427	16	via	via	IN
cord-015021-pol2qm74	5427	17	acting	act	VBG
cord-015021-pol2qm74	5427	18	as	as	IN
cord-015021-pol2qm74	5427	19	chemotaxins	chemotaxins	NNP
cord-015021-pol2qm74	5427	20	,	,	,
cord-015021-pol2qm74	5427	21	blocking	block	VBG
cord-015021-pol2qm74	5427	22	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5427	23	activation	activation	NN
cord-015021-pol2qm74	5427	24	or	or	CC
cord-015021-pol2qm74	5427	25	competing	compete	VBG
cord-015021-pol2qm74	5427	26	with	with	IN
cord-015021-pol2qm74	5427	27	the	the	DT
cord-015021-pol2qm74	5427	28	membrane	membrane	NN
cord-015021-pol2qm74	5427	29	-	-	HYPH
cord-015021-pol2qm74	5427	30	bound	bind	VBN
cord-015021-pol2qm74	5427	31	forms	form	NNS
cord-015021-pol2qm74	5427	32	in	in	IN
cord-015021-pol2qm74	5427	33	cell	cell	NN
cord-015021-pol2qm74	5427	34	-	-	HYPH
cord-015021-pol2qm74	5427	35	cell	cell	NN
cord-015021-pol2qm74	5427	36	adhesion	adhesion	NN
cord-015021-pol2qm74	5427	37	.	.	.
cord-015021-pol2qm74	5428	1	Thus	thus	RB
cord-015021-pol2qm74	5428	2	,	,	,
cord-015021-pol2qm74	5428	3	measuring	measure	VBG
cord-015021-pol2qm74	5428	4	circulating	circulate	VBG
cord-015021-pol2qm74	5428	5	or	or	CC
cord-015021-pol2qm74	5428	6	local	local	JJ
cord-015021-pol2qm74	5428	7	levels	level	NNS
cord-015021-pol2qm74	5428	8	of	of	IN
cord-015021-pol2qm74	5428	9	elastase	elastase	NN
cord-015021-pol2qm74	5428	10	-	-	:
cord-015021-pol2qm74	5428	11	a	a	DT
cord-015021-pol2qm74	5428	12	1PI	1pi	CD
cord-015021-pol2qm74	5428	13	and	and	CC
cord-015021-pol2qm74	5428	14	soluble	soluble	JJ
cord-015021-pol2qm74	5428	15	adhesion	adhesion	NN
cord-015021-pol2qm74	5428	16	molecules	molecule	NNS
cord-015021-pol2qm74	5428	17	(	(	-LRB-
cord-015021-pol2qm74	5428	18	ICAM	ICAM	NNP
cord-015021-pol2qm74	5428	19	,	,	,
cord-015021-pol2qm74	5428	20	E	E	NNP
cord-015021-pol2qm74	5428	21	-	-	NN
cord-015021-pol2qm74	5428	22	selectin,-Pselectin	selectin,-pselectin	RB
cord-015021-pol2qm74	5428	23	,	,	,
cord-015021-pol2qm74	5428	24	L	l	NN
cord-015021-pol2qm74	5428	25	-	-	HYPH
cord-015021-pol2qm74	5428	26	selectin	selectin	NNP
cord-015021-pol2qm74	5428	27	)	)	-RRB-
cord-015021-pol2qm74	5428	28	may	may	MD
cord-015021-pol2qm74	5428	29	be	be	VB
cord-015021-pol2qm74	5428	30	a	a	DT
cord-015021-pol2qm74	5428	31	helpful	helpful	JJ
cord-015021-pol2qm74	5428	32	tool	tool	NN
cord-015021-pol2qm74	5428	33	in	in	IN
cord-015021-pol2qm74	5428	34	judging	judge	VBG
cord-015021-pol2qm74	5428	35	the	the	DT
cord-015021-pol2qm74	5428	36	severity	severity	NN
cord-015021-pol2qm74	5428	37	of	of	IN
cord-015021-pol2qm74	5428	38	an	an	DT
cord-015021-pol2qm74	5428	39	acute	acute	JJ
cord-015021-pol2qm74	5428	40	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5428	41	process	process	NN
cord-015021-pol2qm74	5428	42	.	.	.
cord-015021-pol2qm74	5429	1	In	in	IN
cord-015021-pol2qm74	5429	2	several	several	JJ
cord-015021-pol2qm74	5429	3	clinical	clinical	JJ
cord-015021-pol2qm74	5429	4	studies	study	NNS
cord-015021-pol2qm74	5429	5	on	on	IN
cord-015021-pol2qm74	5429	6	surgical	surgical	JJ
cord-015021-pol2qm74	5429	7	patients	patient	NNS
cord-015021-pol2qm74	5429	8	suffering	suffer	VBG
cord-015021-pol2qm74	5429	9	from	from	IN
cord-015021-pol2qm74	5429	10	multiple	multiple	JJ
cord-015021-pol2qm74	5429	11	trauma	trauma	NN
cord-015021-pol2qm74	5429	12	and/or	and/or	CC
cord-015021-pol2qm74	5429	13	sepsis	sepsis	NN
cord-015021-pol2qm74	5429	14	we	-PRON-	PRP
cord-015021-pol2qm74	5429	15	could	could	MD
cord-015021-pol2qm74	5429	16	demonstrate	demonstrate	VB
cord-015021-pol2qm74	5429	17	that	that	IN
cord-015021-pol2qm74	5429	18	the	the	DT
cord-015021-pol2qm74	5429	19	measurement	measurement	NN
cord-015021-pol2qm74	5429	20	of	of	IN
cord-015021-pol2qm74	5429	21	these	these	DT
cord-015021-pol2qm74	5429	22	parameters	parameter	NNS
cord-015021-pol2qm74	5429	23	in	in	IN
cord-015021-pol2qm74	5429	24	consecutive	consecutive	JJ
cord-015021-pol2qm74	5429	25	plasma	plasma	NN
cord-015021-pol2qm74	5429	26	samples	sample	NNS
cord-015021-pol2qm74	5429	27	and	and	CC
cord-015021-pol2qm74	5429	28	local	local	JJ
cord-015021-pol2qm74	5429	29	body	body	NN
cord-015021-pol2qm74	5429	30	fluids	fluid	NNS
cord-015021-pol2qm74	5429	31	was	be	VBD
cord-015021-pol2qm74	5429	32	highly	highly	RB
cord-015021-pol2qm74	5429	33	valuable	valuable	JJ
cord-015021-pol2qm74	5429	34	for	for	IN
cord-015021-pol2qm74	5429	35	early	early	JJ
cord-015021-pol2qm74	5429	36	diagnosis	diagnosis	NN
cord-015021-pol2qm74	5429	37	and	and	CC
cord-015021-pol2qm74	5429	38	prognosis	prognosis	NN
cord-015021-pol2qm74	5429	39	of	of	IN
cord-015021-pol2qm74	5429	40	multiple	multiple	JJ
cord-015021-pol2qm74	5429	41	organ	organ	NN
cord-015021-pol2qm74	5429	42	failure	failure	NN
cord-015021-pol2qm74	5429	43	.	.	.
cord-015021-pol2qm74	5430	1	Prof.	Prof.	NNP
cord-015021-pol2qm74	5430	2	Dr.	Dr.	NNP
cord-015021-pol2qm74	5430	3	M./ochum	M./ochum	NNP
cord-015021-pol2qm74	5430	4	,	,	,
cord-015021-pol2qm74	5430	5	Institut	Institut	NNP
cord-015021-pol2qm74	5430	6	Fdr	Fdr	NNP
cord-015021-pol2qm74	5430	7	klinischeChemie	klinischeChemie	NNP
cord-015021-pol2qm74	5430	8	und	und	IN
cord-015021-pol2qm74	5430	9	Biochemie	Biochemie	NNP
cord-015021-pol2qm74	5430	10	,	,	,
cord-015021-pol2qm74	5431	1	LMU	LMU	NNP
cord-015021-pol2qm74	5431	2	Miinchen	Miinchen	NNP
cord-015021-pol2qm74	5431	3	,	,	,
cord-015021-pol2qm74	5431	4	Nufibaumstrage	Nufibaumstrage	NNP
cord-015021-pol2qm74	5431	5	20	20	CD
cord-015021-pol2qm74	5431	6	,	,	,
cord-015021-pol2qm74	5431	7	80336	80336	CD
cord-015021-pol2qm74	5432	1	M0nchen	M0nchen	NNP
cord-015021-pol2qm74	5432	2	,	,	,
cord-015021-pol2qm74	5432	3	Germany	Germany	NNP
cord-015021-pol2qm74	5432	4	Procalaitonin	Procalaitonin	NNP
cord-015021-pol2qm74	5432	5	(	(	-LRB-
cord-015021-pol2qm74	5432	6	ProCT	ProCT	NNP
cord-015021-pol2qm74	5432	7	)	)	-RRB-
cord-015021-pol2qm74	5432	8	a	a	DT
cord-015021-pol2qm74	5432	9	116	116	CD
cord-015021-pol2qm74	5432	10	AA	AA	NNP
cord-015021-pol2qm74	5432	11	peptide	peptide	NN
cord-015021-pol2qm74	5432	12	is	be	VBZ
cord-015021-pol2qm74	5432	13	dramatically	dramatically	RB
cord-015021-pol2qm74	5432	14	increased	increase	VBN
cord-015021-pol2qm74	5432	15	in	in	IN
cord-015021-pol2qm74	5432	16	the	the	DT
cord-015021-pol2qm74	5432	17	blood	blood	NN
cord-015021-pol2qm74	5432	18	of	of	IN
cord-015021-pol2qm74	5432	19	patients	patient	NNS
cord-015021-pol2qm74	5432	20	with	with	IN
cord-015021-pol2qm74	5432	21	various	various	JJ
cord-015021-pol2qm74	5432	22	sepsis	sepsis	NN
cord-015021-pol2qm74	5432	23	and	and	CC
cord-015021-pol2qm74	5432	24	infections	infection	NNS
cord-015021-pol2qm74	5432	25	.	.	.
cord-015021-pol2qm74	5433	1	The	the	DT
cord-015021-pol2qm74	5433	2	increase	increase	NN
cord-015021-pol2qm74	5433	3	begins	begin	VBZ
cord-015021-pol2qm74	5433	4	as	as	RB
cord-015021-pol2qm74	5433	5	soon	soon	RB
cord-015021-pol2qm74	5433	6	as	as	IN
cord-015021-pol2qm74	5433	7	3	3	CD
cord-015021-pol2qm74	5433	8	hours	hour	NNS
cord-015021-pol2qm74	5433	9	after	after	IN
cord-015021-pol2qm74	5433	10	the	the	DT
cord-015021-pol2qm74	5433	11	andoto	andoto	NN
cord-015021-pol2qm74	5433	12	:	:	:
cord-015021-pol2qm74	5433	13	edn	edn	NNP
cord-015021-pol2qm74	5433	14	release	release	NN
cord-015021-pol2qm74	5433	15	and	and	CC
cord-015021-pol2qm74	5433	16	readied	readie	VBD
cord-015021-pol2qm74	5433	17	maximal	maximal	JJ
cord-015021-pol2qm74	5433	18	level	level	NN
cord-015021-pol2qm74	5433	19	with	with	IN
cord-015021-pol2qm74	5433	20	a	a	DT
cord-015021-pol2qm74	5433	21	200	200	CD
cord-015021-pol2qm74	5433	22	to	to	IN
cord-015021-pol2qm74	5433	23	80B	80b	NN
cord-015021-pol2qm74	5433	24	-	-	:
cord-015021-pol2qm74	5433	25	fold	fold	RB
cord-015021-pol2qm74	5433	26	increase	increase	NN
cord-015021-pol2qm74	5433	27	24	24	CD
cord-015021-pol2qm74	5433	28	h	h	NN
cord-015021-pol2qm74	5433	29	after	after	IN
cord-015021-pol2qm74	5433	30	LI~	LI~	NNP
cord-015021-pol2qm74	5433	31	edrmrdstration	edrmrdstration	NN
cord-015021-pol2qm74	5433	32	.	.	.
cord-015021-pol2qm74	5434	1	Prcc	Prcc	NNP
cord-015021-pol2qm74	5434	2	,	,	,
cord-015021-pol2qm74	5434	3	alcitorfin	alcitorfin	NN
cord-015021-pol2qm74	5434	4	response	response	NN
cord-015021-pol2qm74	5434	5	was	be	VBD
cord-015021-pol2qm74	5434	6	temporally	temporally	RB
cord-015021-pol2qm74	5434	7	different	different	JJ
cord-015021-pol2qm74	5434	8	from	from	IN
cord-015021-pol2qm74	5434	9	these	these	DT
cord-015021-pol2qm74	5434	10	of	of	IN
cord-015021-pol2qm74	5434	11	TNF~	tnf~	CD
cord-015021-pol2qm74	5434	12	and	and	CC
cord-015021-pol2qm74	5434	13	II-6	II-6	NNP
cord-015021-pol2qm74	5434	14	,	,	,
cord-015021-pol2qm74	5434	15	that	that	WDT
cord-015021-pol2qm74	5434	16	reached	reach	VBD
cord-015021-pol2qm74	5434	17	peak	peak	NN
cord-015021-pol2qm74	5434	18	levels	level	NNS
cord-015021-pol2qm74	5434	19	at	at	IN
cord-015021-pol2qm74	5434	20	2	2	CD
cord-015021-pol2qm74	5434	21	h	h	NN
cord-015021-pol2qm74	5434	22	and	and	CC
cord-015021-pol2qm74	5434	23	3	3	CD
cord-015021-pol2qm74	5434	24	h	h	NN
cord-015021-pol2qm74	5434	25	respectively	respectively	RB
cord-015021-pol2qm74	5434	26	.	.	.
cord-015021-pol2qm74	5435	1	At	at	IN
cord-015021-pol2qm74	5435	2	the	the	DT
cord-015021-pol2qm74	5435	3	opposite	opposite	NN
cord-015021-pol2qm74	5435	4	of	of	IN
cord-015021-pol2qm74	5435	5	eytokine	eytokine	NNP
cord-015021-pol2qm74	5435	6	(	(	-LRB-
cord-015021-pol2qm74	5435	7	TNFcz	TNFcz	NNP
cord-015021-pol2qm74	5435	8	,	,	,
cord-015021-pol2qm74	5435	9	ILd	ILd	NNP
cord-015021-pol2qm74	5435	10	,	,	,
cord-015021-pol2qm74	5435	11	J	J	NNP
cord-015021-pol2qm74	5435	12	,	,	,
cord-015021-pol2qm74	5435	13	Is	be	VBZ
cord-015021-pol2qm74	5435	14	)	)	-RRB-
cord-015021-pol2qm74	5435	15	,	,	,
cord-015021-pol2qm74	5435	16	ProCT	ProCT	NNP
cord-015021-pol2qm74	5435	17	is	be	VBZ
cord-015021-pol2qm74	5435	18	a	a	DT
cord-015021-pol2qm74	5435	19	very	very	RB
cord-015021-pol2qm74	5435	20	stable	stable	JJ
cord-015021-pol2qm74	5435	21	molecule	molecule	NN
cord-015021-pol2qm74	5435	22	.	.	.
cord-015021-pol2qm74	5436	1	The	the	DT
cord-015021-pol2qm74	5436	2	half	half	JJ
cord-015021-pol2qm74	5436	3	Iife	Iife	NNP
cord-015021-pol2qm74	5436	4	of	of	IN
cord-015021-pol2qm74	5436	5	ProCT	ProCT	NNP
cord-015021-pol2qm74	5436	6	in	in	IN
cord-015021-pol2qm74	5437	1	~he	~he	NNP
cord-015021-pol2qm74	5438	1	blood	blood	NN
cord-015021-pol2qm74	5438	2	is	be	VBZ
cord-015021-pol2qm74	5438	3	surprising	surprising	JJ
cord-015021-pol2qm74	5438	4	if	if	IN
cord-015021-pol2qm74	5438	5	we	-PRON-	PRP
cord-015021-pol2qm74	5438	6	consider	consider	VBP
cord-015021-pol2qm74	5438	7	the	the	DT
cord-015021-pol2qm74	5438	8	half	half	JJ
cord-015021-pol2qm74	5438	9	llfe	llfe	NN
cord-015021-pol2qm74	5438	10	(	(	-LRB-
cord-015021-pol2qm74	5438	11	about	about	RB
cord-015021-pol2qm74	5438	12	nine	nine	CD
cord-015021-pol2qm74	5438	13	mirtute	mirtute	NN
cord-015021-pol2qm74	5438	14	)	)	-RRB-
cord-015021-pol2qm74	5438	15	of	of	IN
cord-015021-pol2qm74	5438	16	mature	mature	JJ
cord-015021-pol2qm74	5438	17	¢alcitonin	¢alcitonin	JJ
cord-015021-pol2qm74	5439	1	(	(	-LRB-
cord-015021-pol2qm74	5439	2	CO	CO	NNP
cord-015021-pol2qm74	5439	3	.	.	.
cord-015021-pol2qm74	5440	1	We	-PRON-	PRP
cord-015021-pol2qm74	5440	2	have	have	VBP
cord-015021-pol2qm74	5440	3	found	find	VBN
cord-015021-pol2qm74	5440	4	that	that	IN
cord-015021-pol2qm74	5440	5	it	-PRON-	PRP
cord-015021-pol2qm74	5440	6	is	be	VBZ
cord-015021-pol2qm74	5440	7	due	due	JJ
cord-015021-pol2qm74	5440	8	to	to	IN
cord-015021-pol2qm74	5440	9	the	the	DT
cord-015021-pol2qm74	5440	10	binding	binding	NN
cord-015021-pol2qm74	5440	11	of	of	IN
cord-015021-pol2qm74	5440	12	ProCT	ProCT	NNP
cord-015021-pol2qm74	5440	13	with	with	IN
cord-015021-pol2qm74	5440	14	a	a	DT
cord-015021-pol2qm74	5440	15	protein	protein	NN
cord-015021-pol2qm74	5440	16	on	on	IN
cord-015021-pol2qm74	5440	17	the	the	DT
cord-015021-pol2qm74	5440	18	N	N	NNP
cord-015021-pol2qm74	5440	19	-	-	HYPH
cord-015021-pol2qm74	5440	20	termktal	termktal	NNP
cord-015021-pol2qm74	5440	21	part	part	NN
cord-015021-pol2qm74	5440	22	.	.	.
cord-015021-pol2qm74	5441	1	Thin	thin	JJ
cord-015021-pol2qm74	5441	2	complex	complex	NN
cord-015021-pol2qm74	5441	3	of	of	IN
cord-015021-pol2qm74	5441	4	about	about	RB
cord-015021-pol2qm74	5441	5	80	80	CD
cord-015021-pol2qm74	5441	6	000	000	CD
cord-015021-pol2qm74	5441	7	daltons	dalton	NNS
cord-015021-pol2qm74	5441	8	is	be	VBZ
cord-015021-pol2qm74	5441	9	unable	unable	JJ
cord-015021-pol2qm74	5441	10	to	to	TO
cord-015021-pol2qm74	5441	11	cross	cross	VB
cord-015021-pol2qm74	5441	12	the	the	DT
cord-015021-pol2qm74	5441	13	kidney	kidney	NN
cord-015021-pol2qm74	5441	14	and	and	CC
cord-015021-pol2qm74	5441	15	the	the	DT
cord-015021-pol2qm74	5441	16	C_N9	C_N9	NNP
cord-015021-pol2qm74	5441	17	barriers	barrier	NNS
cord-015021-pol2qm74	5441	18	and	and	CC
cord-015021-pol2qm74	5441	19	the	the	DT
cord-015021-pol2qm74	5441	20	half	half	JJ
cord-015021-pol2qm74	5441	21	life	life	NN
cord-015021-pol2qm74	5441	22	is	be	VBZ
cord-015021-pol2qm74	5441	23	at	at	IN
cord-015021-pol2qm74	5441	24	least	least	JJS
cord-015021-pol2qm74	5441	25	elghteen	elghteen	NNP
cord-015021-pol2qm74	5441	26	hours	hour	NNS
cord-015021-pol2qm74	5441	27	.	.	.
cord-015021-pol2qm74	5442	1	This	this	DT
cord-015021-pol2qm74	5443	1	long	long	JJ
cord-015021-pol2qm74	5443	2	half	half	NNP
cord-015021-pol2qm74	5443	3	llfe	llfe	NNP
cord-015021-pol2qm74	5443	4	is	be	VBZ
cord-015021-pol2qm74	5443	5	very	very	RB
cord-015021-pol2qm74	5443	6	useful	useful	JJ
cord-015021-pol2qm74	5443	7	in	in	IN
cord-015021-pol2qm74	5443	8	the	the	DT
cord-015021-pol2qm74	5443	9	evaluation	evaluation	NN
cord-015021-pol2qm74	5443	10	of	of	IN
cord-015021-pol2qm74	5443	11	a	a	DT
cord-015021-pol2qm74	5443	12	sepsis	sepsis	NN
cord-015021-pol2qm74	5443	13	.	.	.
cord-015021-pol2qm74	5444	1	A	a	DT
cord-015021-pol2qm74	5444	2	very	very	RB
cord-015021-pol2qm74	5444	3	sensitive	sensitive	JJ
cord-015021-pol2qm74	5444	4	and	and	CC
cord-015021-pol2qm74	5444	5	specific	specific	JJ
cord-015021-pol2qm74	5444	6	sandwich	sandwich	NN
cord-015021-pol2qm74	5444	7	in'ununoassay	in'ununoassay	NNP
cord-015021-pol2qm74	5444	8	has	have	VBZ
cord-015021-pol2qm74	5444	9	been	be	VBN
cord-015021-pol2qm74	5444	10	developped	developpe	VBN
cord-015021-pol2qm74	5444	11	.	.	.
cord-015021-pol2qm74	5445	1	The	the	DT
cord-015021-pol2qm74	5445	2	results	result	NNS
cord-015021-pol2qm74	5445	3	cart	cart	NN
cord-015021-pol2qm74	5445	4	be	be	VB
cord-015021-pol2qm74	5445	5	delivered	deliver	VBN
cord-015021-pol2qm74	5445	6	in	in	IN
cord-015021-pol2qm74	5445	7	tWO	two	CD
cord-015021-pol2qm74	5445	8	hours	hour	NNS
cord-015021-pol2qm74	5445	9	.	.	.
cord-015021-pol2qm74	5446	1	At	at	IN
cord-015021-pol2qm74	5446	2	time	time	NN
cord-015021-pol2qm74	5446	3	,	,	,
cord-015021-pol2qm74	5446	4	we	-PRON-	PRP
cord-015021-pol2qm74	5446	5	know	know	VBP
cord-015021-pol2qm74	5446	6	that	that	IN
cord-015021-pol2qm74	5446	7	in	in	IN
cord-015021-pol2qm74	5446	8	the	the	DT
cord-015021-pol2qm74	5446	9	healthy	healthy	JJ
cord-015021-pol2qm74	5446	10	adults	adult	NNS
cord-015021-pol2qm74	5446	11	,	,	,
cord-015021-pol2qm74	5446	12	the	the	DT
cord-015021-pol2qm74	5446	13	values	value	NNS
cord-015021-pol2qm74	5446	14	are	be	VBP
cord-015021-pol2qm74	5446	15	less	less	JJR
cord-015021-pol2qm74	5446	16	thau	thau	NNP
cord-015021-pol2qm74	5446	17	0.1ng	0.1ng	NNP
cord-015021-pol2qm74	5446	18	/	/	SYM
cord-015021-pol2qm74	5446	19	ml	ml	NN
cord-015021-pol2qm74	5446	20	.	.	.
cord-015021-pol2qm74	5447	1	It	-PRON-	PRP
cord-015021-pol2qm74	5447	2	is	be	VBZ
cord-015021-pol2qm74	5447	3	also	also	RB
cord-015021-pol2qm74	5447	4	clear	clear	JJ
cord-015021-pol2qm74	5447	5	that	that	IN
cord-015021-pol2qm74	5447	6	ProCT	ProCT	NNP
cord-015021-pol2qm74	5447	7	is	be	VBZ
cord-015021-pol2qm74	5447	8	not	not	RB
cord-015021-pol2qm74	5447	9	increased	increase	VBN
cord-015021-pol2qm74	5448	1	~n	~n	NNP
cord-015021-pol2qm74	5448	2	patients	patient	NNS
cord-015021-pol2qm74	5448	3	wlth	wlth	VBP
cord-015021-pol2qm74	5448	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5448	5	dleeasea	dleeasea	NNP
cord-015021-pol2qm74	5448	6	without	without	IN
cord-015021-pol2qm74	5448	7	lnfectlon	lnfectlon	NNP
cord-015021-pol2qm74	5448	8	.	.	.
cord-015021-pol2qm74	5449	1	For	for	IN
cord-015021-pol2qm74	5449	2	instance	instance	NN
cord-015021-pol2qm74	5449	3	,	,	,
cord-015021-pol2qm74	5449	4	ProCT	ProCT	NNP
cord-015021-pol2qm74	5449	5	is	be	VBZ
cord-015021-pol2qm74	5449	6	not	not	RB
cord-015021-pol2qm74	5449	7	signLffcat3vely	signLffcat3vely	NNP
cord-015021-pol2qm74	5449	8	increased	increase	VBN
cord-015021-pol2qm74	5449	9	in	in	IN
cord-015021-pol2qm74	5449	10	purpura	purpura	NNP
cord-015021-pol2qm74	5449	11	rhumatoM	rhumatoM	NNP
cord-015021-pol2qm74	5449	12	,	,	,
cord-015021-pol2qm74	5449	13	arthritis	arthritis	NN
cord-015021-pol2qm74	5449	14	,	,	,
cord-015021-pol2qm74	5449	15	Crohn	Crohn	NNP
cord-015021-pol2qm74	5449	16	's	's	POS
cord-015021-pol2qm74	5449	17	disease	disease	NN
cord-015021-pol2qm74	5449	18	,	,	,
cord-015021-pol2qm74	5449	19	rectocolitis	rectocolitis	NNP
cord-015021-pol2qm74	5449	20	,	,	,
cord-015021-pol2qm74	5449	21	also	also	RB
cord-015021-pol2qm74	5449	22	in	in	IN
cord-015021-pol2qm74	5449	23	various	various	JJ
cord-015021-pol2qm74	5449	24	cancer	cancer	NN
cord-015021-pol2qm74	5449	25	patients	patient	NNS
cord-015021-pol2qm74	5449	26	with	with	IN
cord-015021-pol2qm74	5449	27	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5449	28	components	component	NNS
cord-015021-pol2qm74	5449	29	.	.	.
cord-015021-pol2qm74	5450	1	Am	be	VBP
cord-015021-pol2qm74	5450	2	other	other	JJ
cord-015021-pol2qm74	5450	3	interesting	interesting	JJ
cord-015021-pol2qm74	5450	4	finding	finding	NN
cord-015021-pol2qm74	5450	5	,	,	,
cord-015021-pol2qm74	5450	6	is	be	VBZ
cord-015021-pol2qm74	5450	7	the	the	DT
cord-015021-pol2qm74	5450	8	absence	absence	NN
cord-015021-pol2qm74	5450	9	of	of	IN
cord-015021-pol2qm74	5450	10	increase	increase	NN
cord-015021-pol2qm74	5450	11	or	or	CC
cord-015021-pol2qm74	5450	12	a	a	DT
cord-015021-pol2qm74	5450	13	very	very	RB
cord-015021-pol2qm74	5450	14	low	low	JJ
cord-015021-pol2qm74	5450	15	increase	increase	NN
cord-015021-pol2qm74	5450	16	in	in	IN
cord-015021-pol2qm74	5450	17	the	the	DT
cord-015021-pol2qm74	5450	18	viral	viral	JJ
cord-015021-pol2qm74	5450	19	infections	infection	NNS
cord-015021-pol2qm74	5450	20	.	.	.
cord-015021-pol2qm74	5451	1	At	at	IN
cord-015021-pol2qm74	5451	2	the	the	DT
cord-015021-pol2qm74	5451	3	opp0site	opp0site	NNP
cord-015021-pol2qm74	5451	4	,	,	,
cord-015021-pol2qm74	5451	5	in	in	IN
cord-015021-pol2qm74	5451	6	all	all	PDT
cord-015021-pol2qm74	5451	7	the	the	DT
cord-015021-pol2qm74	5451	8	patients	patient	NNS
cord-015021-pol2qm74	5451	9	with	with	IN
cord-015021-pol2qm74	5451	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	5451	11	sepsis	sepsis	NN
cord-015021-pol2qm74	5451	12	or	or	CC
cord-015021-pol2qm74	5451	13	in	in	IN
cord-015021-pol2qm74	5451	14	the	the	DT
cord-015021-pol2qm74	5451	15	malaria	malaria	NNP
cord-015021-pol2qm74	5451	16	pat	pat	NNP
cord-015021-pol2qm74	5451	17	/	/	SYM
cord-015021-pol2qm74	5451	18	ants	ant	NNS
cord-015021-pol2qm74	5451	19	,	,	,
cord-015021-pol2qm74	5451	20	ProGT	ProGT	NNP
cord-015021-pol2qm74	5451	21	was	be	VBD
cord-015021-pol2qm74	5451	22	dramatically	dramatically	RB
cord-015021-pol2qm74	5451	23	increased	increase	VBN
cord-015021-pol2qm74	5451	24	,	,	,
cord-015021-pol2qm74	5451	25	from	from	IN
cord-015021-pol2qm74	5451	26	I00	I00	NNP
cord-015021-pol2qm74	5451	27	to	to	IN
cord-015021-pol2qm74	5451	28	10	10	CD
cord-015021-pol2qm74	5451	29	000	000	CD
cord-015021-pol2qm74	5451	30	fold	fold	NN
cord-015021-pol2qm74	5451	31	.	.	.
cord-015021-pol2qm74	5452	1	P	p	NN
cord-015021-pol2qm74	5452	2	~	~	CD
cord-015021-pol2qm74	5452	3	oCT	oct	PRP
cord-015021-pol2qm74	5452	4	can	can	MD
cord-015021-pol2qm74	5452	5	be	be	VB
cord-015021-pol2qm74	5452	6	useful	useful	JJ
cord-015021-pol2qm74	5452	7	to	to	IN
cord-015021-pol2qm74	5452	8	the	the	DT
cord-015021-pol2qm74	5452	9	follow	follow	NN
cord-015021-pol2qm74	5452	10	up	up	IN
cord-015021-pol2qm74	5452	11	of	of	IN
cord-015021-pol2qm74	5452	12	patients	patient	NNS
cord-015021-pol2qm74	5452	13	with	with	IN
cord-015021-pol2qm74	5452	14	sepsis	sepsis	NN
cord-015021-pol2qm74	5452	15	.	.	.
cord-015021-pol2qm74	5453	1	Actually	actually	RB
cord-015021-pol2qm74	5453	2	,	,	,
cord-015021-pol2qm74	5453	3	we	-PRON-	PRP
cord-015021-pol2qm74	5453	4	do	do	VBP
cord-015021-pol2qm74	5453	5	n't	not	RB
cord-015021-pol2qm74	5453	6	know	know	VB
cord-015021-pol2qm74	5453	7	the	the	DT
cord-015021-pol2qm74	5453	8	origin	origin	NN
cord-015021-pol2qm74	5453	9	of	of	IN
cord-015021-pol2qm74	5453	10	this	this	DT
cord-015021-pol2qm74	5453	11	ProCT	ProCT	NNP
cord-015021-pol2qm74	5453	12	production	production	NN
cord-015021-pol2qm74	5453	13	,	,	,
cord-015021-pol2qm74	5453	14	in	in	IN
cord-015021-pol2qm74	5453	15	the	the	DT
cord-015021-pol2qm74	5453	16	United	United	NNP
cord-015021-pol2qm74	5453	17	States	States	NNP
cord-015021-pol2qm74	5453	18	,	,	,
cord-015021-pol2qm74	5453	19	will	will	MD
cord-015021-pol2qm74	5453	20	also	also	RB
cord-015021-pol2qm74	5453	21	be	be	VB
cord-015021-pol2qm74	5453	22	discussed	discuss	VBN
cord-015021-pol2qm74	5453	23	.	.	.
cord-015021-pol2qm74	5454	1	The	the	DT
cord-015021-pol2qm74	5454	2	SepTest	SepTest	NNP
cord-015021-pol2qm74	5454	3	portion	portion	NN
cord-015021-pol2qm74	5454	4	of	of	IN
cord-015021-pol2qm74	5454	5	this	this	DT
cord-015021-pol2qm74	5454	6	study	study	NN
cord-015021-pol2qm74	5454	7	will	will	MD
cord-015021-pol2qm74	5454	8	eventually	eventually	RB
cord-015021-pol2qm74	5454	9	enroll	enroll	VB
cord-015021-pol2qm74	5454	10	over	over	IN
cord-015021-pol2qm74	5454	11	500	500	CD
cord-015021-pol2qm74	5454	12	patients	patient	NNS
cord-015021-pol2qm74	5454	13	tentatively	tentatively	RB
cord-015021-pol2qm74	5454	14	diagnosed	diagnose	VBN
cord-015021-pol2qm74	5454	15	as	as	IN
cord-015021-pol2qm74	5454	16	septic	septic	NN
cord-015021-pol2qm74	5454	17	.	.	.
cord-015021-pol2qm74	5455	1	The	the	DT
cord-015021-pol2qm74	5455	2	results	result	NNS
cord-015021-pol2qm74	5455	3	of	of	IN
cord-015021-pol2qm74	5455	4	SepTest	SepTest	NNP
cord-015021-pol2qm74	5455	5	will	will	MD
cord-015021-pol2qm74	5455	6	be	be	VB
cord-015021-pol2qm74	5455	7	compared	compare	VBN
cord-015021-pol2qm74	5455	8	with	with	IN
cord-015021-pol2qm74	5455	9	commonly	commonly	RB
cord-015021-pol2qm74	5455	10	accepted	accept	VBN
cord-015021-pol2qm74	5455	11	symptoms	symptom	NNS
cord-015021-pol2qm74	5455	12	and	and	CC
cord-015021-pol2qm74	5455	13	criteria	criterion	NNS
cord-015021-pol2qm74	5455	14	associated	associate	VBN
cord-015021-pol2qm74	5455	15	with	with	IN
cord-015021-pol2qm74	5455	16	sepsis	sepsis	NN
cord-015021-pol2qm74	5455	17	in	in	IN
cord-015021-pol2qm74	5455	18	order	order	NN
cord-015021-pol2qm74	5455	19	to	to	TO
cord-015021-pol2qm74	5455	20	determine	determine	VB
cord-015021-pol2qm74	5455	21	the	the	DT
cord-015021-pol2qm74	5455	22	clinical	clinical	JJ
cord-015021-pol2qm74	5455	23	utility	utility	NN
cord-015021-pol2qm74	5455	24	of	of	IN
cord-015021-pol2qm74	5455	25	this	this	DT
cord-015021-pol2qm74	5455	26	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5455	27	assay	assay	NN
cord-015021-pol2qm74	5455	28	.	.	.
cord-015021-pol2qm74	5456	1	Preclinical	preclinical	JJ
cord-015021-pol2qm74	5456	2	results	result	NNS
cord-015021-pol2qm74	5456	3	of	of	IN
cord-015021-pol2qm74	5456	4	patients	patient	NNS
cord-015021-pol2qm74	5456	5	and	and	CC
cord-015021-pol2qm74	5456	6	normals	normal	NNS
cord-015021-pol2qm74	5456	7	be	be	VB
cord-015021-pol2qm74	5456	8	presented	present	VBN
cord-015021-pol2qm74	5456	9	as	as	RB
cord-015021-pol2qm74	5456	10	well	well	RB
cord-015021-pol2qm74	5456	11	as	as	IN
cord-015021-pol2qm74	5456	12	data	datum	NNS
cord-015021-pol2qm74	5456	13	on	on	IN
cord-015021-pol2qm74	5456	14	the	the	DT
cord-015021-pol2qm74	5456	15	time	time	NN
cord-015021-pol2qm74	5456	16	course	course	NN
cord-015021-pol2qm74	5456	17	of	of	IN
cord-015021-pol2qm74	5456	18	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	5456	19	and	and	CC
cord-015021-pol2qm74	5456	20	clinical	clinical	JJ
cord-015021-pol2qm74	5456	21	outcome	outcome	NN
cord-015021-pol2qm74	5456	22	of	of	IN
cord-015021-pol2qm74	5456	23	selected	select	VBN
cord-015021-pol2qm74	5456	24	septic	septic	JJ
cord-015021-pol2qm74	5456	25	patients	patient	NNS
cord-015021-pol2qm74	5456	26	.	.	.
cord-015021-pol2qm74	5457	1	Preparation	preparation	NN
cord-015021-pol2qm74	5457	2	of	of	IN
cord-015021-pol2qm74	5457	3	DNA	DNA	NNP
cord-015021-pol2qm74	5457	4	Libraries	Libraries	NNPS
cord-015021-pol2qm74	5457	5	Clifford	Clifford	NNP
cord-015021-pol2qm74	5457	6	W.	W.	NNP
cord-015021-pol2qm74	5457	7	Schweinfest	Schweinfest	NNP
cord-015021-pol2qm74	5457	8	,	,	,
cord-015021-pol2qm74	5457	9	Ph.D.	Ph.D.	NNP
cord-015021-pol2qm74	5457	10	A	a	DT
cord-015021-pol2qm74	5457	11	fundamental	fundamental	JJ
cord-015021-pol2qm74	5457	12	tool	tool	NN
cord-015021-pol2qm74	5457	13	of	of	IN
cord-015021-pol2qm74	5457	14	the	the	DT
cord-015021-pol2qm74	5457	15	molecular	molecular	JJ
cord-015021-pol2qm74	5457	16	biologist	biologist	NN
cord-015021-pol2qm74	5457	17	today	today	NN
cord-015021-pol2qm74	5457	18	is	be	VBZ
cord-015021-pol2qm74	5457	19	the	the	DT
cord-015021-pol2qm74	5457	20	ability	ability	NN
cord-015021-pol2qm74	5457	21	to	to	TO
cord-015021-pol2qm74	5457	22	work	work	VB
cord-015021-pol2qm74	5457	23	with	with	IN
cord-015021-pol2qm74	5457	24	purified	purify	VBN
cord-015021-pol2qm74	5457	25	DNAs	dna	NNS
cord-015021-pol2qm74	5457	26	representing	represent	VBG
cord-015021-pol2qm74	5457	27	genes	gene	NNS
cord-015021-pol2qm74	5457	28	of	of	IN
cord-015021-pol2qm74	5457	29	interest	interest	NN
cord-015021-pol2qm74	5457	30	with	with	IN
cord-015021-pol2qm74	5457	31	respect	respect	NN
cord-015021-pol2qm74	5457	32	to	to	IN
cord-015021-pol2qm74	5457	33	the	the	DT
cord-015021-pol2qm74	5457	34	investigator	investigator	NN
cord-015021-pol2qm74	5457	35	's	's	POS
cord-015021-pol2qm74	5457	36	field	field	NN
cord-015021-pol2qm74	5457	37	of	of	IN
cord-015021-pol2qm74	5457	38	study	study	NN
cord-015021-pol2qm74	5457	39	.	.	.
cord-015021-pol2qm74	5458	1	Originally	originally	RB
cord-015021-pol2qm74	5458	2	applied	apply	VBD
cord-015021-pol2qm74	5458	3	almost	almost	RB
cord-015021-pol2qm74	5458	4	20	20	CD
cord-015021-pol2qm74	5458	5	years	year	NNS
cord-015021-pol2qm74	5458	6	ago	ago	RB
cord-015021-pol2qm74	5458	7	to	to	IN
cord-015021-pol2qm74	5458	8	the	the	DT
cord-015021-pol2qm74	5458	9	genetic	genetic	JJ
cord-015021-pol2qm74	5458	10	dissection	dissection	NN
cord-015021-pol2qm74	5458	11	of	of	IN
cord-015021-pol2qm74	5458	12	simple	simple	JJ
cord-015021-pol2qm74	5458	13	organisms	organism	NNS
cord-015021-pol2qm74	5458	14	such	such	JJ
cord-015021-pol2qm74	5458	15	as	as	IN
cord-015021-pol2qm74	5458	16	viruses	virus	NNS
cord-015021-pol2qm74	5458	17	and	and	CC
cord-015021-pol2qm74	5458	18	bacteria	bacteria	NNS
cord-015021-pol2qm74	5458	19	,	,	,
cord-015021-pol2qm74	5458	20	molecfllar	molecfllar	NN
cord-015021-pol2qm74	5458	21	cloning	cloning	NN
cord-015021-pol2qm74	5458	22	was	be	VBD
cord-015021-pol2qm74	5458	23	rapidly	rapidly	RB
cord-015021-pol2qm74	5458	24	applied	apply	VBN
cord-015021-pol2qm74	5458	25	to	to	TO
cord-015021-pol2qm74	5458	26	study	study	VB
cord-015021-pol2qm74	5458	27	the	the	DT
cord-015021-pol2qm74	5458	28	more	more	RBR
cord-015021-pol2qm74	5458	29	complex	complex	JJ
cord-015021-pol2qm74	5458	30	genetics	genetic	NNS
cord-015021-pol2qm74	5458	31	of	of	IN
cord-015021-pol2qm74	5458	32	the	the	DT
cord-015021-pol2qm74	5458	33	mammalian	mammalian	JJ
cord-015021-pol2qm74	5458	34	cell	cell	NN
cord-015021-pol2qm74	5458	35	.	.	.
cord-015021-pol2qm74	5459	1	Today	today	NN
cord-015021-pol2qm74	5459	2	,	,	,
cord-015021-pol2qm74	5459	3	virtually	virtually	RB
cord-015021-pol2qm74	5459	4	any	any	DT
cord-015021-pol2qm74	5459	5	study	study	NN
cord-015021-pol2qm74	5459	6	of	of	IN
cord-015021-pol2qm74	5459	7	cell	cell	NN
cord-015021-pol2qm74	5459	8	physiology	physiology	NN
cord-015021-pol2qm74	5459	9	which	which	WDT
cord-015021-pol2qm74	5459	10	depends	depend	VBZ
cord-015021-pol2qm74	5459	11	upon	upon	IN
cord-015021-pol2qm74	5459	12	specific	specific	JJ
cord-015021-pol2qm74	5459	13	gene	gene	NN
cord-015021-pol2qm74	5459	14	expression	expression	NN
cord-015021-pol2qm74	5459	15	is	be	VBZ
cord-015021-pol2qm74	5459	16	approachable	approachable	JJ
cord-015021-pol2qm74	5459	17	using	use	VBG
cord-015021-pol2qm74	5459	18	the	the	DT
cord-015021-pol2qm74	5459	19	tools	tool	NNS
cord-015021-pol2qm74	5459	20	of	of	IN
cord-015021-pol2qm74	5459	21	the	the	DT
cord-015021-pol2qm74	5459	22	molecular	molecular	JJ
cord-015021-pol2qm74	5459	23	biologist	biologist	NN
cord-015021-pol2qm74	5459	24	.	.	.
cord-015021-pol2qm74	5460	1	Therefore	therefore	RB
cord-015021-pol2qm74	5460	2	,	,	,
cord-015021-pol2qm74	5460	3	stress	stress	NN
cord-015021-pol2qm74	5460	4	induced	induce	VBN
cord-015021-pol2qm74	5460	5	gene	gene	NN
cord-015021-pol2qm74	5460	6	expression	expression	NN
cord-015021-pol2qm74	5460	7	(	(	-LRB-
cord-015021-pol2qm74	5460	8	such	such	JJ
cord-015021-pol2qm74	5460	9	as	as	IN
cord-015021-pol2qm74	5460	10	the	the	DT
cord-015021-pol2qm74	5460	11	heat	heat	NN
cord-015021-pol2qm74	5460	12	shock	shock	NN
cord-015021-pol2qm74	5460	13	gene	gene	NN
cord-015021-pol2qm74	5460	14	,	,	,
cord-015021-pol2qm74	5460	15	hsp70	hsp70	ADD
cord-015021-pol2qm74	5460	16	)	)	-RRB-
cord-015021-pol2qm74	5460	17	or	or	CC
cord-015021-pol2qm74	5460	18	the	the	DT
cord-015021-pol2qm74	5460	19	regulation	regulation	NN
cord-015021-pol2qm74	5460	20	of	of	IN
cord-015021-pol2qm74	5460	21	the	the	DT
cord-015021-pol2qm74	5460	22	nitric	nitric	NN
cord-015021-pol2qm74	5460	23	oxide	oxide	NN
cord-015021-pol2qm74	5460	24	synthetase	synthetase	NN
cord-015021-pol2qm74	5460	25	gene	gene	NN
cord-015021-pol2qm74	5460	26	or	or	CC
cord-015021-pol2qm74	5460	27	the	the	DT
cord-015021-pol2qm74	5460	28	induction	induction	NN
cord-015021-pol2qm74	5460	29	of	of	IN
cord-015021-pol2qm74	5460	30	cytokines	cytokine	NNS
cord-015021-pol2qm74	5460	31	and	and	CC
cord-015021-pol2qm74	5460	32	growth	growth	NN
cord-015021-pol2qm74	5460	33	factors	factor	NNS
cord-015021-pol2qm74	5460	34	as	as	IN
cord-015021-pol2qm74	5460	35	a	a	DT
cord-015021-pol2qm74	5460	36	result	result	NN
cord-015021-pol2qm74	5460	37	of	of	IN
cord-015021-pol2qm74	5460	38	trauma	trauma	NN
cord-015021-pol2qm74	5460	39	or	or	CC
cord-015021-pol2qm74	5460	40	injury	injury	NN
cord-015021-pol2qm74	5460	41	lend	lend	VBP
cord-015021-pol2qm74	5460	42	themselves	-PRON-	PRP
cord-015021-pol2qm74	5460	43	to	to	IN
cord-015021-pol2qm74	5460	44	investigation	investigation	NN
cord-015021-pol2qm74	5460	45	at	at	IN
cord-015021-pol2qm74	5460	46	the	the	DT
cord-015021-pol2qm74	5460	47	level	level	NN
cord-015021-pol2qm74	5460	48	of	of	IN
cord-015021-pol2qm74	5460	49	the	the	DT
cord-015021-pol2qm74	5460	50	gene	gene	NN
cord-015021-pol2qm74	5460	51	.	.	.
cord-015021-pol2qm74	5461	1	During	during	IN
cord-015021-pol2qm74	5461	2	these	these	DT
cord-015021-pol2qm74	5461	3	workshops	workshop	NNS
cord-015021-pol2qm74	5461	4	,	,	,
cord-015021-pol2qm74	5461	5	we	-PRON-	PRP
cord-015021-pol2qm74	5461	6	will	will	MD
cord-015021-pol2qm74	5461	7	discuss	discuss	VB
cord-015021-pol2qm74	5461	8	the	the	DT
cord-015021-pol2qm74	5461	9	means	mean	NNS
cord-015021-pol2qm74	5461	10	by	by	IN
cord-015021-pol2qm74	5461	11	which	which	WDT
cord-015021-pol2qm74	5461	12	cDNAs	cdna	NNS
cord-015021-pol2qm74	5461	13	and	and	CC
cord-015021-pol2qm74	5461	14	genes	gene	NNS
cord-015021-pol2qm74	5461	15	are	be	VBP
cord-015021-pol2qm74	5461	16	isolated	isolate	VBN
cord-015021-pol2qm74	5461	17	,	,	,
cord-015021-pol2qm74	5461	18	amplified	amplify	VBN
cord-015021-pol2qm74	5461	19	and	and	CC
cord-015021-pol2qm74	5461	20	identified	identify	VBN
cord-015021-pol2qm74	5461	21	.	.	.
cord-015021-pol2qm74	5462	1	We	-PRON-	PRP
cord-015021-pol2qm74	5462	2	will	will	MD
cord-015021-pol2qm74	5462	3	discuss	discuss	VB
cord-015021-pol2qm74	5462	4	the	the	DT
cord-015021-pol2qm74	5462	5	strategies	strategy	NNS
cord-015021-pol2qm74	5462	6	and	and	CC
cord-015021-pol2qm74	5462	7	methods	method	NNS
cord-015021-pol2qm74	5462	8	for	for	IN
cord-015021-pol2qm74	5462	9	cloning	clone	VBG
cord-015021-pol2qm74	5462	10	cDNAs	cdna	NNS
cord-015021-pol2qm74	5462	11	and	and	CC
cord-015021-pol2qm74	5462	12	genomic	genomic	JJ
cord-015021-pol2qm74	5462	13	DNAs	dna	NNS
cord-015021-pol2qm74	5462	14	,	,	,
cord-015021-pol2qm74	5462	15	for	for	IN
cord-015021-pol2qm74	5462	16	organizing	organize	VBG
cord-015021-pol2qm74	5462	17	such	such	JJ
cord-015021-pol2qm74	5462	18	cloned	clone	VBN
cord-015021-pol2qm74	5462	19	libraries	library	NNS
cord-015021-pol2qm74	5462	20	,	,	,
cord-015021-pol2qm74	5462	21	for	for	IN
cord-015021-pol2qm74	5462	22	finding	find	VBG
cord-015021-pol2qm74	5462	23	specific	specific	JJ
cord-015021-pol2qm74	5462	24	genes	gene	NNS
cord-015021-pol2qm74	5462	25	and	and	CC
cord-015021-pol2qm74	5462	26	for	for	IN
cord-015021-pol2qm74	5462	27	characterizing	characterize	VBG
cord-015021-pol2qm74	5462	28	those	those	DT
cord-015021-pol2qm74	5462	29	genes	gene	NNS
cord-015021-pol2qm74	5462	30	.	.	.
cord-015021-pol2qm74	5463	1	This	this	DT
cord-015021-pol2qm74	5463	2	speaker	speaker	NN
cord-015021-pol2qm74	5463	3	will	will	MD
cord-015021-pol2qm74	5463	4	focus	focus	VB
cord-015021-pol2qm74	5463	5	on	on	IN
cord-015021-pol2qm74	5463	6	the	the	DT
cord-015021-pol2qm74	5463	7	techniques	technique	NNS
cord-015021-pol2qm74	5463	8	and	and	CC
cord-015021-pol2qm74	5463	9	considerations	consideration	NNS
cord-015021-pol2qm74	5463	10	involved	involve	VBN
cord-015021-pol2qm74	5463	11	in	in	IN
cord-015021-pol2qm74	5463	12	the	the	DT
cord-015021-pol2qm74	5463	13	synthesis	synthesis	NN
cord-015021-pol2qm74	5463	14	of	of	IN
cord-015021-pol2qm74	5463	15	cDNA	cDNA	NNP
cord-015021-pol2qm74	5463	16	libraries	library	NNS
cord-015021-pol2qm74	5463	17	.	.	.
cord-015021-pol2qm74	5464	1	Topics	topic	NNS
cord-015021-pol2qm74	5464	2	include	include	VBP
cord-015021-pol2qm74	5464	3	RNA	RNA	NNP
cord-015021-pol2qm74	5464	4	isolation	isolation	NN
cord-015021-pol2qm74	5464	5	,	,	,
cord-015021-pol2qm74	5464	6	mRNA	mrna	NN
cord-015021-pol2qm74	5464	7	quality	quality	NN
cord-015021-pol2qm74	5464	8	,	,	,
cord-015021-pol2qm74	5464	9	reverse	reverse	VB
cord-015021-pol2qm74	5464	10	transcription	transcription	NN
cord-015021-pol2qm74	5464	11	,	,	,
cord-015021-pol2qm74	5464	12	choice	choice	NN
cord-015021-pol2qm74	5464	13	of	of	IN
cord-015021-pol2qm74	5464	14	cloning	clone	VBG
cord-015021-pol2qm74	5464	15	vectors	vector	NNS
cord-015021-pol2qm74	5464	16	and	and	CC
cord-015021-pol2qm74	5464	17	library	library	NN
cord-015021-pol2qm74	5464	18	quality	quality	NN
cord-015021-pol2qm74	5464	19	.	.	.
cord-015021-pol2qm74	5465	1	Genomic	genomic	JJ
cord-015021-pol2qm74	5465	2	DNA	dna	NN
cord-015021-pol2qm74	5465	3	library	library	NN
cord-015021-pol2qm74	5465	4	synthesis	synthesis	NN
cord-015021-pol2qm74	5465	5	will	will	MD
cord-015021-pol2qm74	5465	6	also	also	RB
cord-015021-pol2qm74	5465	7	be	be	VB
cord-015021-pol2qm74	5465	8	discussed	discuss	VBN
cord-015021-pol2qm74	5465	9	with	with	IN
cord-015021-pol2qm74	5465	10	respect	respect	NN
cord-015021-pol2qm74	5465	11	to	to	IN
cord-015021-pol2qm74	5465	12	the	the	DT
cord-015021-pol2qm74	5465	13	vector	vector	NN
cord-015021-pol2qm74	5465	14	/	/	SYM
cord-015021-pol2qm74	5465	15	host	host	NN
cord-015021-pol2qm74	5465	16	systems	system	NNS
cord-015021-pol2qm74	5465	17	available	available	JJ
cord-015021-pol2qm74	5465	18	and	and	CC
cord-015021-pol2qm74	5465	19	applications	application	NNS
cord-015021-pol2qm74	5465	20	which	which	WDT
cord-015021-pol2qm74	5465	21	are	be	VBP
cord-015021-pol2qm74	5465	22	specific	specific	JJ
cord-015021-pol2qm74	5465	23	to	to	IN
cord-015021-pol2qm74	5465	24	genomic	genomic	JJ
cord-015021-pol2qm74	5465	25	DNA	dna	NN
cord-015021-pol2qm74	5465	26	.	.	.
cord-015021-pol2qm74	5466	1	Finally	finally	RB
cord-015021-pol2qm74	5466	2	,	,	,
cord-015021-pol2qm74	5466	3	polymerase	polymerase	NN
cord-015021-pol2qm74	5466	4	chain	chain	NN
cord-015021-pol2qm74	5466	5	reaction	reaction	NN
cord-015021-pol2qm74	5466	6	(	(	-LRB-
cord-015021-pol2qm74	5466	7	PCR	PCR	NNP
cord-015021-pol2qm74	5466	8	)	)	-RRB-
cord-015021-pol2qm74	5466	9	will	will	MD
cord-015021-pol2qm74	5466	10	be	be	VB
cord-015021-pol2qm74	5466	11	discussed	discuss	VBN
cord-015021-pol2qm74	5466	12	briefly	briefly	RB
cord-015021-pol2qm74	5466	13	with	with	IN
cord-015021-pol2qm74	5466	14	regard	regard	NN
cord-015021-pol2qm74	5466	15	to	to	IN
cord-015021-pol2qm74	5466	16	its	-PRON-	PRP$
cord-015021-pol2qm74	5466	17	impact	impact	NN
cord-015021-pol2qm74	5466	18	on	on	IN
cord-015021-pol2qm74	5466	19	DNA	dna	NN
cord-015021-pol2qm74	5466	20	cloning	cloning	NN
cord-015021-pol2qm74	5466	21	.	.	.
cord-015021-pol2qm74	5467	1	The	the	DT
cord-015021-pol2qm74	5467	2	identification	identification	NN
cord-015021-pol2qm74	5467	3	of	of	IN
cord-015021-pol2qm74	5467	4	the	the	DT
cord-015021-pol2qm74	5467	5	genes	gene	NNS
cord-015021-pol2qm74	5467	6	or	or	CC
cord-015021-pol2qm74	5467	7	gene	gene	NN
cord-015021-pol2qm74	5467	8	products	product	NNS
cord-015021-pol2qm74	5467	9	that	that	WDT
cord-015021-pol2qm74	5467	10	have	have	VBP
cord-015021-pol2qm74	5467	11	a	a	DT
cord-015021-pol2qm74	5467	12	role	role	NN
cord-015021-pol2qm74	5467	13	in	in	IN
cord-015021-pol2qm74	5467	14	cellular	cellular	JJ
cord-015021-pol2qm74	5467	15	processes	process	NNS
cord-015021-pol2qm74	5467	16	is	be	VBZ
cord-015021-pol2qm74	5467	17	fundamental	fundamental	JJ
cord-015021-pol2qm74	5467	18	to	to	IN
cord-015021-pol2qm74	5467	19	our	-PRON-	PRP$
cord-015021-pol2qm74	5467	20	understanding	understanding	NN
cord-015021-pol2qm74	5467	21	of	of	IN
cord-015021-pol2qm74	5467	22	genetic	genetic	JJ
cord-015021-pol2qm74	5467	23	control	control	NN
cord-015021-pol2qm74	5467	24	and	and	CC
cord-015021-pol2qm74	5467	25	methodologies	methodology	NNS
cord-015021-pol2qm74	5467	26	to	to	TO
cord-015021-pol2qm74	5467	27	achieve	achieve	VB
cord-015021-pol2qm74	5467	28	this	this	DT
cord-015021-pol2qm74	5467	29	aim	aim	NN
cord-015021-pol2qm74	5467	30	are	be	VBP
cord-015021-pol2qm74	5467	31	currently	currently	RB
cord-015021-pol2qm74	5467	32	available	available	JJ
cord-015021-pol2qm74	5467	33	.	.	.
cord-015021-pol2qm74	5468	1	All	all	DT
cord-015021-pol2qm74	5468	2	levels	level	NNS
cord-015021-pol2qm74	5468	3	of	of	IN
cord-015021-pol2qm74	5468	4	the	the	DT
cord-015021-pol2qm74	5468	5	various	various	JJ
cord-015021-pol2qm74	5468	6	signal	signal	NN
cord-015021-pol2qm74	5468	7	transduction	transduction	NN
cord-015021-pol2qm74	5468	8	pathways	pathway	NNS
cord-015021-pol2qm74	5468	9	can	can	MD
cord-015021-pol2qm74	5468	10	b~	b~	VB
cord-015021-pol2qm74	5468	11	molecularly	molecularly	RB
cord-015021-pol2qm74	5468	12	analyzed	analyze	VBN
cord-015021-pol2qm74	5468	13	to	to	TO
cord-015021-pol2qm74	5468	14	define	define	VB
cord-015021-pol2qm74	5468	15	the	the	DT
cord-015021-pol2qm74	5468	16	mechanism	mechanism	NN
cord-015021-pol2qm74	5468	17	by	by	IN
cord-015021-pol2qm74	5468	18	which	which	WDT
cord-015021-pol2qm74	5468	19	critical	critical	JJ
cord-015021-pol2qm74	5468	20	steps	step	NNS
cord-015021-pol2qm74	5468	21	in	in	IN
cord-015021-pol2qm74	5468	22	each	each	DT
cord-015021-pol2qm74	5468	23	pathway	pathway	NN
cord-015021-pol2qm74	5468	24	are	be	VBP
cord-015021-pol2qm74	5468	25	achieved	achieve	VBN
cord-015021-pol2qm74	5468	26	.	.	.
cord-015021-pol2qm74	5469	1	The	the	DT
cord-015021-pol2qm74	5469	2	questions	question	NNS
cord-015021-pol2qm74	5469	3	that	that	WDT
cord-015021-pol2qm74	5469	4	are	be	VBP
cord-015021-pol2qm74	5469	5	unresolved	unresolved	JJ
cord-015021-pol2qm74	5469	6	in	in	IN
cord-015021-pol2qm74	5469	7	each	each	DT
cord-015021-pol2qm74	5469	8	area	area	NN
cord-015021-pol2qm74	5469	9	of	of	IN
cord-015021-pol2qm74	5469	10	investigation	investigation	NN
cord-015021-pol2qm74	5469	11	serve	serve	VBP
cord-015021-pol2qm74	5469	12	to	to	TO
cord-015021-pol2qm74	5469	13	direct	direct	VB
cord-015021-pol2qm74	5469	14	the	the	DT
cord-015021-pol2qm74	5469	15	scientist	scientist	NN
cord-015021-pol2qm74	5469	16	towards	towards	IN
cord-015021-pol2qm74	5469	17	analyses	analysis	NNS
cord-015021-pol2qm74	5469	18	of	of	IN
cord-015021-pol2qm74	5469	19	gene	gene	NN
cord-015021-pol2qm74	5469	20	products	product	NNS
cord-015021-pol2qm74	5469	21	or	or	CC
cord-015021-pol2qm74	5469	22	gene	gene	NN
cord-015021-pol2qm74	5469	23	regulation	regulation	NN
cord-015021-pol2qm74	5469	24	of	of	IN
cord-015021-pol2qm74	5469	25	the	the	DT
cord-015021-pol2qm74	5469	26	gene	gene	NN
cord-015021-pol2qm74	5469	27	itself	-PRON-	PRP
cord-015021-pol2qm74	5469	28	.	.	.
cord-015021-pol2qm74	5470	1	Thus	thus	RB
cord-015021-pol2qm74	5470	2	,	,	,
cord-015021-pol2qm74	5470	3	selection	selection	NN
cord-015021-pol2qm74	5470	4	of	of	IN
cord-015021-pol2qm74	5470	5	the	the	DT
cord-015021-pol2qm74	5470	6	type	type	NN
cord-015021-pol2qm74	5470	7	of	of	IN
cord-015021-pol2qm74	5470	8	library	library	NN
cord-015021-pol2qm74	5470	9	(	(	-LRB-
cord-015021-pol2qm74	5470	10	genomic	genomic	JJ
cord-015021-pol2qm74	5470	11	or	or	CC
cord-015021-pol2qm74	5470	12	cDNA	cdna	NN
cord-015021-pol2qm74	5470	13	)	)	-RRB-
cord-015021-pol2qm74	5470	14	to	to	TO
cord-015021-pol2qm74	5470	15	be	be	VB
cord-015021-pol2qm74	5470	16	used	use	VBN
cord-015021-pol2qm74	5470	17	is	be	VBZ
cord-015021-pol2qm74	5470	18	dependent	dependent	JJ
cord-015021-pol2qm74	5470	19	upon	upon	IN
cord-015021-pol2qm74	5470	20	the	the	DT
cord-015021-pol2qm74	5470	21	specific	specific	JJ
cord-015021-pol2qm74	5470	22	goals	goal	NNS
cord-015021-pol2qm74	5470	23	of	of	IN
cord-015021-pol2qm74	5470	24	each	each	DT
cord-015021-pol2qm74	5470	25	investigator	investigator	NN
cord-015021-pol2qm74	5470	26	.	.	.
cord-015021-pol2qm74	5471	1	To	to	TO
cord-015021-pol2qm74	5471	2	facilitate	facilitate	VB
cord-015021-pol2qm74	5471	3	resolution	resolution	NN
cord-015021-pol2qm74	5471	4	of	of	IN
cord-015021-pol2qm74	5471	5	this	this	DT
cord-015021-pol2qm74	5471	6	question	question	NN
cord-015021-pol2qm74	5471	7	,	,	,
cord-015021-pol2qm74	5471	8	an	an	DT
cord-015021-pol2qm74	5471	9	overview	overview	NN
cord-015021-pol2qm74	5471	10	of	of	IN
cord-015021-pol2qm74	5471	11	the	the	DT
cord-015021-pol2qm74	5471	12	uses	use	NNS
cord-015021-pol2qm74	5471	13	for	for	IN
cord-015021-pol2qm74	5471	14	the	the	DT
cord-015021-pol2qm74	5471	15	different	different	JJ
cord-015021-pol2qm74	5471	16	types	type	NNS
cord-015021-pol2qm74	5471	17	of	of	IN
cord-015021-pol2qm74	5471	18	libraries	library	NNS
cord-015021-pol2qm74	5471	19	will	will	MD
cord-015021-pol2qm74	5471	20	be	be	VB
cord-015021-pol2qm74	5471	21	presented	present	VBN
cord-015021-pol2qm74	5471	22	.	.	.
cord-015021-pol2qm74	5472	1	At	at	RB
cord-015021-pol2qm74	5472	2	least	least	JJS
cord-015021-pol2qm74	5472	3	four	four	CD
cord-015021-pol2qm74	5472	4	methodologies	methodology	NNS
cord-015021-pol2qm74	5472	5	are	be	VBP
cord-015021-pol2qm74	5472	6	currently	currently	RB
cord-015021-pol2qm74	5472	7	available	available	JJ
cord-015021-pol2qm74	5472	8	for	for	IN
cord-015021-pol2qm74	5472	9	screening	screen	VBG
cord-015021-pol2qm74	5472	10	a	a	DT
cord-015021-pol2qm74	5472	11	library	library	NN
cord-015021-pol2qm74	5472	12	,	,	,
cord-015021-pol2qm74	5472	13	which	which	WDT
cord-015021-pol2qm74	5472	14	are	be	VBP
cord-015021-pol2qm74	5472	15	dependent	dependent	JJ
cord-015021-pol2qm74	5472	16	upon	upon	IN
cord-015021-pol2qm74	5472	17	specific	specific	JJ
cord-015021-pol2qm74	5472	18	interaction	interaction	NN
cord-015021-pol2qm74	5472	19	between	between	IN
cord-015021-pol2qm74	5472	20	nucleic	nucleic	JJ
cord-015021-pol2qm74	5472	21	acids	acid	NNS
cord-015021-pol2qm74	5472	22	,	,	,
cord-015021-pol2qm74	5472	23	nucleic	nucleic	JJ
cord-015021-pol2qm74	5472	24	acids	acid	NNS
cord-015021-pol2qm74	5472	25	and	and	CC
cord-015021-pol2qm74	5472	26	proteins	protein	NNS
cord-015021-pol2qm74	5472	27	,	,	,
cord-015021-pol2qm74	5472	28	antibodies	antibody	NNS
cord-015021-pol2qm74	5472	29	and	and	CC
cord-015021-pol2qm74	5472	30	antigens	antigen	NNS
cord-015021-pol2qm74	5472	31	or	or	CC
cord-015021-pol2qm74	5472	32	between	between	IN
cord-015021-pol2qm74	5472	33	different	different	JJ
cord-015021-pol2qm74	5472	34	proteins	protein	NNS
cord-015021-pol2qm74	5472	35	.	.	.
cord-015021-pol2qm74	5473	1	The	the	DT
cord-015021-pol2qm74	5473	2	use	use	NN
cord-015021-pol2qm74	5473	3	and	and	CC
cord-015021-pol2qm74	5473	4	advantages	advantage	NNS
cord-015021-pol2qm74	5473	5	of	of	IN
cord-015021-pol2qm74	5473	6	each	each	DT
cord-015021-pol2qm74	5473	7	of	of	IN
cord-015021-pol2qm74	5473	8	these	these	DT
cord-015021-pol2qm74	5473	9	methodologies	methodology	NNS
cord-015021-pol2qm74	5473	10	will	will	MD
cord-015021-pol2qm74	5473	11	be	be	VB
cord-015021-pol2qm74	5473	12	discussed	discuss	VBN
cord-015021-pol2qm74	5473	13	along	along	IN
cord-015021-pol2qm74	5473	14	with	with	IN
cord-015021-pol2qm74	5473	15	a	a	DT
cord-015021-pol2qm74	5473	16	description	description	NN
cord-015021-pol2qm74	5473	17	of	of	IN
cord-015021-pol2qm74	5473	18	probe	probe	NN
cord-015021-pol2qm74	5473	19	preparation	preparation	NN
cord-015021-pol2qm74	5473	20	.	.	.
cord-015021-pol2qm74	5474	1	Sequence	sequence	NN
cord-015021-pol2qm74	5474	2	methodologies	methodology	NNS
cord-015021-pol2qm74	5474	3	required	require	VBN
cord-015021-pol2qm74	5474	4	to	to	TO
cord-015021-pol2qm74	5474	5	begin	begin	VB
cord-015021-pol2qm74	5474	6	characterization	characterization	NN
cord-015021-pol2qm74	5474	7	of	of	IN
cord-015021-pol2qm74	5474	8	gene	gene	NN
cord-015021-pol2qm74	5474	9	clones	clone	NNS
cord-015021-pol2qm74	5474	10	will	will	MD
cord-015021-pol2qm74	5474	11	be	be	VB
cord-015021-pol2qm74	5474	12	presented	present	VBN
cord-015021-pol2qm74	5474	13	.	.	.
cord-015021-pol2qm74	5475	1	Hopefully	hopefully	RB
cord-015021-pol2qm74	5475	2	,	,	,
cord-015021-pol2qm74	5475	3	the	the	DT
cord-015021-pol2qm74	5475	4	participants	participant	NNS
cord-015021-pol2qm74	5475	5	in	in	IN
cord-015021-pol2qm74	5475	6	the	the	DT
cord-015021-pol2qm74	5475	7	workshop	workshop	NN
cord-015021-pol2qm74	5475	8	will	will	MD
cord-015021-pol2qm74	5475	9	help	help	VB
cord-015021-pol2qm74	5475	10	define	define	VB
cord-015021-pol2qm74	5475	11	areas	area	NNS
cord-015021-pol2qm74	5475	12	of	of	IN
cord-015021-pol2qm74	5475	13	emphasis	emphasis	NN
cord-015021-pol2qm74	5475	14	and	and	CC
cord-015021-pol2qm74	5475	15	allow	allow	VB
cord-015021-pol2qm74	5475	16	time	time	NN
cord-015021-pol2qm74	5475	17	for	for	IN
cord-015021-pol2qm74	5475	18	directed	direct	VBN
cord-015021-pol2qm74	5475	19	interaction	interaction	NN
cord-015021-pol2qm74	5475	20	to	to	TO
cord-015021-pol2qm74	5475	21	discuss	discuss	VB
cord-015021-pol2qm74	5475	22	specific	specific	JJ
cord-015021-pol2qm74	5475	23	applications	application	NNS
cord-015021-pol2qm74	5475	24	based	base	VBN
cord-015021-pol2qm74	5475	25	upon	upon	IN
cord-015021-pol2qm74	5475	26	their	-PRON-	PRP$
cord-015021-pol2qm74	5475	27	own	own	JJ
cord-015021-pol2qm74	5475	28	experimental	experimental	JJ
cord-015021-pol2qm74	5475	29	systems	system	NNS
cord-015021-pol2qm74	5475	30	.	.	.
cord-015021-pol2qm74	5475	31	 	 	_SP
cord-015021-pol2qm74	5476	1	Alterations	alteration	NNS
cord-015021-pol2qm74	5476	2	of	of	IN
cord-015021-pol2qm74	5476	3	physiological	physiological	JJ
cord-015021-pol2qm74	5476	4	conditions	condition	NNS
cord-015021-pol2qm74	5476	5	,	,	,
cord-015021-pol2qm74	5476	6	such	such	JJ
cord-015021-pol2qm74	5476	7	as	as	IN
cord-015021-pol2qm74	5476	8	those	those	DT
cord-015021-pol2qm74	5476	9	occurring	occur	VBG
cord-015021-pol2qm74	5476	10	after	after	IN
cord-015021-pol2qm74	5476	11	shock	shock	NN
cord-015021-pol2qm74	5476	12	and	and	CC
cord-015021-pol2qm74	5476	13	sepsis	sepsis	NN
cord-015021-pol2qm74	5476	14	,	,	,
cord-015021-pol2qm74	5476	15	induce	induce	VB
cord-015021-pol2qm74	5476	16	changes	change	NNS
cord-015021-pol2qm74	5476	17	in	in	IN
cord-015021-pol2qm74	5476	18	gene	gene	NN
cord-015021-pol2qm74	5476	19	expression	expression	NN
cord-015021-pol2qm74	5476	20	of	of	IN
cord-015021-pol2qm74	5476	21	cells	cell	NNS
cord-015021-pol2qm74	5476	22	composing	compose	VBG
cord-015021-pol2qm74	5476	23	the	the	DT
cord-015021-pol2qm74	5476	24	major	major	JJ
cord-015021-pol2qm74	5476	25	organ	organ	NN
cord-015021-pol2qm74	5476	26	systems	system	NNS
cord-015021-pol2qm74	5476	27	.	.	.
cord-015021-pol2qm74	5477	1	The	the	DT
cord-015021-pol2qm74	5477	2	challenge	challenge	NN
cord-015021-pol2qm74	5477	3	is	be	VBZ
cord-015021-pol2qm74	5477	4	to	to	TO
cord-015021-pol2qm74	5477	5	detect	detect	VB
cord-015021-pol2qm74	5477	6	and	and	CC
cord-015021-pol2qm74	5477	7	characterize	characterize	VB
cord-015021-pol2qm74	5477	8	these	these	DT
cord-015021-pol2qm74	5477	9	changes	change	NNS
cord-015021-pol2qm74	5477	10	in	in	IN
cord-015021-pol2qm74	5477	11	geae	geae	NNP
cord-015021-pol2qm74	5477	12	expression	expression	NN
cord-015021-pol2qm74	5477	13	and	and	CC
cord-015021-pol2qm74	5477	14	relate	relate	VB
cord-015021-pol2qm74	5477	15	them	-PRON-	PRP
cord-015021-pol2qm74	5477	16	to	to	IN
cord-015021-pol2qm74	5477	17	the	the	DT
cord-015021-pol2qm74	5477	18	injury	injury	NN
cord-015021-pol2qm74	5477	19	.	.	.
cord-015021-pol2qm74	5478	1	The	the	DT
cord-015021-pol2qm74	5478	2	development	development	NN
cord-015021-pol2qm74	5478	3	of	of	IN
cord-015021-pol2qm74	5478	4	cloning	clone	VBG
cord-015021-pol2qm74	5478	5	techniques	technique	NNS
cord-015021-pol2qm74	5478	6	has	have	VBZ
cord-015021-pol2qm74	5478	7	emerged	emerge	VBN
cord-015021-pol2qm74	5478	8	as	as	IN
cord-015021-pol2qm74	5478	9	the	the	DT
cord-015021-pol2qm74	5478	10	methodology	methodology	NN
cord-015021-pol2qm74	5478	11	of	of	IN
cord-015021-pol2qm74	5478	12	choice	choice	NN
cord-015021-pol2qm74	5478	13	.	.	.
cord-015021-pol2qm74	5479	1	Changes	change	NNS
cord-015021-pol2qm74	5479	2	in	in	IN
cord-015021-pol2qm74	5479	3	gene	gene	NN
cord-015021-pol2qm74	5479	4	expression	expression	NN
cord-015021-pol2qm74	5479	5	are	be	VBP
cord-015021-pol2qm74	5479	6	usually	usually	RB
cord-015021-pol2qm74	5479	7	characterized	characterize	VBN
cord-015021-pol2qm74	5479	8	by	by	IN
cord-015021-pol2qm74	5479	9	variations	variation	NNS
cord-015021-pol2qm74	5479	10	in	in	IN
cord-015021-pol2qm74	5479	11	the	the	DT
cord-015021-pol2qm74	5479	12	concentration	concentration	NN
cord-015021-pol2qm74	5479	13	of	of	IN
cord-015021-pol2qm74	5479	14	cellular	cellular	JJ
cord-015021-pol2qm74	5479	15	messages	message	NNS
cord-015021-pol2qm74	5479	16	because	because	IN
cord-015021-pol2qm74	5479	17	synthesis	synthesis	NN
cord-015021-pol2qm74	5479	18	of	of	IN
cord-015021-pol2qm74	5479	19	the	the	DT
cord-015021-pol2qm74	5479	20	final	final	JJ
cord-015021-pol2qm74	5479	21	product	product	NN
cord-015021-pol2qm74	5479	22	"	"	``
cord-015021-pol2qm74	5479	23	the	the	DT
cord-015021-pol2qm74	5479	24	polypoptide	polypoptide	NN
cord-015021-pol2qm74	5479	25	"	"	``
cord-015021-pol2qm74	5479	26	is	be	VBZ
cord-015021-pol2qm74	5479	27	usually	usually	RB
cord-015021-pol2qm74	5479	28	proportional	proportional	JJ
cord-015021-pol2qm74	5479	29	to	to	IN
cord-015021-pol2qm74	5479	30	the	the	DT
cord-015021-pol2qm74	5479	31	concentration	concentration	NN
cord-015021-pol2qm74	5479	32	of	of	IN
cord-015021-pol2qm74	5479	33	mRNA	mRNA	NNP
cord-015021-pol2qm74	5479	34	.	.	.
cord-015021-pol2qm74	5480	1	Due	due	IN
cord-015021-pol2qm74	5480	2	to	to	IN
cord-015021-pol2qm74	5480	3	the	the	DT
cord-015021-pol2qm74	5480	4	rapid	rapid	JJ
cord-015021-pol2qm74	5480	5	regulation	regulation	NN
cord-015021-pol2qm74	5480	6	of	of	IN
cord-015021-pol2qm74	5480	7	gene	gene	NN
cord-015021-pol2qm74	5480	8	expression	expression	NN
cord-015021-pol2qm74	5480	9	the	the	DT
cord-015021-pol2qm74	5480	10	cellular	cellular	JJ
cord-015021-pol2qm74	5480	11	concentration	concentration	NN
cord-015021-pol2qm74	5480	12	of	of	IN
cord-015021-pol2qm74	5480	13	messages	message	NNS
cord-015021-pol2qm74	5480	14	changes	change	NNS
cord-015021-pol2qm74	5480	15	very	very	RB
cord-015021-pol2qm74	5480	16	quickly	quickly	RB
cord-015021-pol2qm74	5480	17	.	.	.
cord-015021-pol2qm74	5481	1	This	this	DT
cord-015021-pol2qm74	5481	2	is	be	VBZ
cord-015021-pol2qm74	5481	3	commonly	commonly	RB
cord-015021-pol2qm74	5481	4	referred	refer	VBN
cord-015021-pol2qm74	5481	5	to	to	IN
cord-015021-pol2qm74	5481	6	as	as	RB
cord-015021-pol2qm74	5481	7	steady	steady	JJ
cord-015021-pol2qm74	5481	8	-	-	HYPH
cord-015021-pol2qm74	5481	9	state	state	NN
cord-015021-pol2qm74	5481	10	levels	level	NNS
cord-015021-pol2qm74	5481	11	,	,	,
cord-015021-pol2qm74	5481	12	a	a	DT
cord-015021-pol2qm74	5481	13	balance	balance	NN
cord-015021-pol2qm74	5481	14	between	between	IN
cord-015021-pol2qm74	5481	15	transcription	transcription	NN
cord-015021-pol2qm74	5481	16	and	and	CC
cord-015021-pol2qm74	5481	17	degradation	degradation	NN
cord-015021-pol2qm74	5481	18	.	.	.
cord-015021-pol2qm74	5482	1	Steady	steady	JJ
cord-015021-pol2qm74	5482	2	-	-	HYPH
cord-015021-pol2qm74	5482	3	state	state	NN
cord-015021-pol2qm74	5482	4	levels	level	NNS
cord-015021-pol2qm74	5482	5	of	of	IN
cord-015021-pol2qm74	5482	6	mRNA	mrna	NN
cord-015021-pol2qm74	5482	7	can	can	MD
cord-015021-pol2qm74	5482	8	be	be	VB
cord-015021-pol2qm74	5482	9	detected	detect	VBN
cord-015021-pol2qm74	5482	10	in	in	IN
cord-015021-pol2qm74	5482	11	a	a	DT
cord-015021-pol2qm74	5482	12	single	single	JJ
cord-015021-pol2qm74	5482	13	cell	cell	NN
cord-015021-pol2qm74	5482	14	(	(	-LRB-
cord-015021-pol2qm74	5482	15	in	in	IN
cord-015021-pol2qm74	5482	16	situ	situ	NN
cord-015021-pol2qm74	5482	17	hybridization	hybridization	NN
cord-015021-pol2qm74	5482	18	)	)	-RRB-
cord-015021-pol2qm74	5482	19	or	or	CC
cord-015021-pol2qm74	5482	20	in	in	IN
cord-015021-pol2qm74	5482	21	total	total	JJ
cord-015021-pol2qm74	5482	22	RNA	RNA	NNP
cord-015021-pol2qm74	5482	23	isolated	isolate	VBN
cord-015021-pol2qm74	5482	24	from	from	IN
cord-015021-pol2qm74	5482	25	cells	cell	NNS
cord-015021-pol2qm74	5482	26	or	or	CC
cord-015021-pol2qm74	5482	27	organs	organ	NNS
cord-015021-pol2qm74	5482	28	and	and	CC
cord-015021-pol2qm74	5482	29	separated	separate	VBD
cord-015021-pol2qm74	5482	30	in	in	IN
cord-015021-pol2qm74	5482	31	agarose	agarose	JJ
cord-015021-pol2qm74	5482	32	gels	gel	NNS
cord-015021-pol2qm74	5482	33	(	(	-LRB-
cord-015021-pol2qm74	5482	34	Northern	northern	JJ
cord-015021-pol2qm74	5482	35	blots	blot	NNS
cord-015021-pol2qm74	5482	36	)	)	-RRB-
cord-015021-pol2qm74	5482	37	.	.	.
cord-015021-pol2qm74	5483	1	Although	although	IN
cord-015021-pol2qm74	5483	2	analysis	analysis	NN
cord-015021-pol2qm74	5483	3	of	of	IN
cord-015021-pol2qm74	5483	4	mRNA	mRNA	NNP
cord-015021-pol2qm74	5483	5	steady	steady	JJ
cord-015021-pol2qm74	5483	6	-	-	HYPH
cord-015021-pol2qm74	5483	7	state	state	NN
cord-015021-pol2qm74	5483	8	levels	level	NNS
cord-015021-pol2qm74	5483	9	are	be	VBP
cord-015021-pol2qm74	5483	10	very	very	RB
cord-015021-pol2qm74	5483	11	useful	useful	JJ
cord-015021-pol2qm74	5483	12	,	,	,
cord-015021-pol2qm74	5483	13	they	-PRON-	PRP
cord-015021-pol2qm74	5483	14	do	do	VBP
cord-015021-pol2qm74	5483	15	not	not	RB
cord-015021-pol2qm74	5483	16	provide	provide	VB
cord-015021-pol2qm74	5483	17	information	information	NN
cord-015021-pol2qm74	5483	18	about	about	IN
cord-015021-pol2qm74	5483	19	the	the	DT
cord-015021-pol2qm74	5483	20	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5483	21	that	that	WDT
cord-015021-pol2qm74	5483	22	regulate	regulate	VBP
cord-015021-pol2qm74	5483	23	gene	gene	NN
cord-015021-pol2qm74	5483	24	expression	expression	NN
cord-015021-pol2qm74	5483	25	.	.	.
cord-015021-pol2qm74	5484	1	Changes	change	NNS
cord-015021-pol2qm74	5484	2	in	in	IN
cord-015021-pol2qm74	5484	3	gene	gene	NN
cord-015021-pol2qm74	5484	4	expression	expression	NN
cord-015021-pol2qm74	5484	5	primarily	primarily	RB
cord-015021-pol2qm74	5484	6	occur	occur	VBP
cord-015021-pol2qm74	5484	7	at	at	IN
cord-015021-pol2qm74	5484	8	the	the	DT
cord-015021-pol2qm74	5484	9	level	level	NN
cord-015021-pol2qm74	5484	10	of	of	IN
cord-015021-pol2qm74	5484	11	transcription	transcription	NN
cord-015021-pol2qm74	5484	12	;	;	:
cord-015021-pol2qm74	5484	13	characterization	characterization	NN
cord-015021-pol2qm74	5484	14	of	of	IN
cord-015021-pol2qm74	5484	15	the	the	DT
cord-015021-pol2qm74	5484	16	RNA	RNA	NNP
cord-015021-pol2qm74	5484	17	species	specie	NNS
cord-015021-pol2qm74	5484	18	being	be	VBG
cord-015021-pol2qm74	5484	19	synthesized	synthesize	VBN
cord-015021-pol2qm74	5484	20	at	at	IN
cord-015021-pol2qm74	5484	21	a	a	DT
cord-015021-pol2qm74	5484	22	given	give	VBN
cord-015021-pol2qm74	5484	23	time	time	NN
cord-015021-pol2qm74	5484	24	is	be	VBZ
cord-015021-pol2qm74	5484	25	performed	perform	VBN
cord-015021-pol2qm74	5484	26	by	by	IN
cord-015021-pol2qm74	5484	27	the	the	DT
cord-015021-pol2qm74	5484	28	nuclear	nuclear	JJ
cord-015021-pol2qm74	5484	29	run	run	NN
cord-015021-pol2qm74	5484	30	-	-	HYPH
cord-015021-pol2qm74	5484	31	off	off	RP
cord-015021-pol2qm74	5484	32	technique	technique	NN
cord-015021-pol2qm74	5484	33	.	.	.
cord-015021-pol2qm74	5485	1	When	when	WRB
cord-015021-pol2qm74	5485	2	there	there	EX
cord-015021-pol2qm74	5485	3	is	be	VBZ
cord-015021-pol2qm74	5485	4	no	no	DT
cord-015021-pol2qm74	5485	5	a	a	FW
cord-015021-pol2qm74	5485	6	priori	priori	FW
cord-015021-pol2qm74	5485	7	information	information	NN
cord-015021-pol2qm74	5485	8	about	about	IN
cord-015021-pol2qm74	5485	9	the	the	DT
cord-015021-pol2qm74	5485	10	gene	gene	NN
cord-015021-pol2qm74	5485	11	that	that	WDT
cord-015021-pol2qm74	5485	12	may	may	MD
cord-015021-pol2qm74	5485	13	be	be	VB
cord-015021-pol2qm74	5485	14	regulated	regulate	VBN
cord-015021-pol2qm74	5485	15	after	after	IN
cord-015021-pol2qm74	5485	16	a	a	DT
cord-015021-pol2qm74	5485	17	particular	particular	JJ
cord-015021-pol2qm74	5485	18	situation	situation	NN
cord-015021-pol2qm74	5485	19	such	such	JJ
cord-015021-pol2qm74	5485	20	as	as	IN
cord-015021-pol2qm74	5485	21	sepsis	sepsis	NN
cord-015021-pol2qm74	5485	22	,	,	,
cord-015021-pol2qm74	5485	23	the	the	DT
cord-015021-pol2qm74	5485	24	total	total	JJ
cord-015021-pol2qm74	5485	25	pool	pool	NN
cord-015021-pol2qm74	5485	26	of	of	IN
cord-015021-pol2qm74	5485	27	messages	message	NNS
cord-015021-pol2qm74	5485	28	present	present	JJ
cord-015021-pol2qm74	5485	29	in	in	IN
cord-015021-pol2qm74	5485	30	cells	cell	NNS
cord-015021-pol2qm74	5485	31	at	at	IN
cord-015021-pol2qm74	5485	32	given	give	VBN
cord-015021-pol2qm74	5485	33	time	time	NN
cord-015021-pol2qm74	5485	34	can	can	MD
cord-015021-pol2qm74	5485	35	be	be	VB
cord-015021-pol2qm74	5485	36	characterized	characterize	VBN
cord-015021-pol2qm74	5485	37	by	by	IN
cord-015021-pol2qm74	5485	38	a	a	DT
cord-015021-pol2qm74	5485	39	combination	combination	NN
cord-015021-pol2qm74	5485	40	of	of	IN
cord-015021-pol2qm74	5485	41	in	in	FW
cord-015021-pol2qm74	5485	42	vitro	vitro	FW
cord-015021-pol2qm74	5485	43	translation	translation	NN
cord-015021-pol2qm74	5485	44	of	of	IN
cord-015021-pol2qm74	5485	45	the	the	DT
cord-015021-pol2qm74	5485	46	cellular	cellular	JJ
cord-015021-pol2qm74	5485	47	messages	message	NNS
cord-015021-pol2qm74	5485	48	and	and	CC
cord-015021-pol2qm74	5485	49	fractionation	fractionation	NN
cord-015021-pol2qm74	5485	50	of	of	IN
cord-015021-pol2qm74	5485	51	the	the	DT
cord-015021-pol2qm74	5485	52	in	in	FW
cord-015021-pol2qm74	5485	53	vitro	vitro	FW
cord-015021-pol2qm74	5485	54	translated	translate	VBN
cord-015021-pol2qm74	5485	55	products	product	NNS
cord-015021-pol2qm74	5485	56	by	by	IN
cord-015021-pol2qm74	5485	57	two	two	CD
cord-015021-pol2qm74	5485	58	dimensional	dimensional	JJ
cord-015021-pol2qm74	5485	59	gel	gel	NN
cord-015021-pol2qm74	5485	60	electrophoresis	electrophoresis	NN
cord-015021-pol2qm74	5485	61	.	.	.
cord-015021-pol2qm74	5486	1	Such	such	JJ
cord-015021-pol2qm74	5486	2	approach	approach	NN
cord-015021-pol2qm74	5486	3	permits	permit	VBZ
cord-015021-pol2qm74	5486	4	the	the	DT
cord-015021-pol2qm74	5486	5	visualization	visualization	NN
cord-015021-pol2qm74	5486	6	of	of	IN
cord-015021-pol2qm74	5486	7	the	the	DT
cord-015021-pol2qm74	5486	8	general	general	JJ
cord-015021-pol2qm74	5486	9	pattern	pattern	NN
cord-015021-pol2qm74	5486	10	of	of	IN
cord-015021-pol2qm74	5486	11	gene	gene	NN
cord-015021-pol2qm74	5486	12	expression	expression	NN
cord-015021-pol2qm74	5486	13	,	,	,
cord-015021-pol2qm74	5486	14	a	a	DT
cord-015021-pol2qm74	5486	15	"	"	``
cord-015021-pol2qm74	5486	16	finger	finger	NN
cord-015021-pol2qm74	5486	17	print	print	NN
cord-015021-pol2qm74	5486	18	"	"	''
cord-015021-pol2qm74	5486	19	,	,	,
cord-015021-pol2qm74	5486	20	of	of	IN
cord-015021-pol2qm74	5486	21	the	the	DT
cord-015021-pol2qm74	5486	22	physiologic	physiologic	JJ
cord-015021-pol2qm74	5486	23	state	state	NN
cord-015021-pol2qm74	5486	24	.	.	.
cord-015021-pol2qm74	5487	1	In	in	IN
cord-015021-pol2qm74	5487	2	summary	summary	NN
cord-015021-pol2qm74	5487	3	,	,	,
cord-015021-pol2qm74	5487	4	researchers	researcher	NNS
cord-015021-pol2qm74	5487	5	now	now	RB
cord-015021-pol2qm74	5487	6	have	have	VBP
cord-015021-pol2qm74	5487	7	access	access	NN
cord-015021-pol2qm74	5487	8	to	to	IN
cord-015021-pol2qm74	5487	9	a	a	DT
cord-015021-pol2qm74	5487	10	great	great	JJ
cord-015021-pol2qm74	5487	11	variety	variety	NN
cord-015021-pol2qm74	5487	12	of	of	IN
cord-015021-pol2qm74	5487	13	techniques	technique	NNS
cord-015021-pol2qm74	5487	14	to	to	TO
cord-015021-pol2qm74	5487	15	identify	identify	VB
cord-015021-pol2qm74	5487	16	and	and	CC
cord-015021-pol2qm74	5487	17	characterize	characterize	VB
cord-015021-pol2qm74	5487	18	genes	gene	NNS
cord-015021-pol2qm74	5487	19	expressed	express	VBN
cord-015021-pol2qm74	5487	20	in	in	IN
cord-015021-pol2qm74	5487	21	response	response	NN
cord-015021-pol2qm74	5487	22	to	to	IN
cord-015021-pol2qm74	5487	23	a	a	DT
cord-015021-pol2qm74	5487	24	physiological	physiological	JJ
cord-015021-pol2qm74	5487	25	condition	condition	NN
cord-015021-pol2qm74	5487	26	that	that	WDT
cord-015021-pol2qm74	5487	27	may	may	MD
cord-015021-pol2qm74	5487	28	be	be	VB
cord-015021-pol2qm74	5487	29	utilized	utilize	VBN
cord-015021-pol2qm74	5487	30	as	as	IN
cord-015021-pol2qm74	5487	31	"	"	``
cord-015021-pol2qm74	5487	32	molecular	molecular	JJ
cord-015021-pol2qm74	5487	33	tools	tool	NNS
cord-015021-pol2qm74	5487	34	"	"	''
cord-015021-pol2qm74	5487	35	to	to	TO
cord-015021-pol2qm74	5487	36	study	study	VB
cord-015021-pol2qm74	5487	37	the	the	DT
cord-015021-pol2qm74	5487	38	organism	organism	NN
cord-015021-pol2qm74	5487	39	's	's	POS
cord-015021-pol2qm74	5487	40	responses	response	NNS
cord-015021-pol2qm74	5487	41	to	to	TO
cord-015021-pol2qm74	5487	42	shock	shock	VB
cord-015021-pol2qm74	5487	43	and	and	CC
cord-015021-pol2qm74	5487	44	sepsis	sepsis	NN
cord-015021-pol2qm74	5487	45	.	.	.
cord-015021-pol2qm74	5488	1	The	the	DT
cord-015021-pol2qm74	5488	2	acute	acute	JJ
cord-015021-pol2qm74	5488	3	phase	phase	NN
cord-015021-pol2qm74	5488	4	proteins	protein	NNS
cord-015021-pol2qm74	5488	5	are	be	VBP
cord-015021-pol2qm74	5488	6	a	a	DT
cord-015021-pol2qm74	5488	7	set	set	NN
cord-015021-pol2qm74	5488	8	of	of	IN
cord-015021-pol2qm74	5488	9	plasma	plasma	NN
cord-015021-pol2qm74	5488	10	proteins	protein	NNS
cord-015021-pol2qm74	5488	11	with	with	IN
cord-015021-pol2qm74	5488	12	greatly	greatly	RB
cord-015021-pol2qm74	5488	13	increased	increase	VBN
cord-015021-pol2qm74	5488	14	plasma	plasma	NN
cord-015021-pol2qm74	5488	15	concentrations	concentration	NNS
cord-015021-pol2qm74	5488	16	during	during	IN
cord-015021-pol2qm74	5488	17	acute	acute	JJ
cord-015021-pol2qm74	5488	18	inflammations	inflammation	NNS
cord-015021-pol2qm74	5488	19	and	and	CC
cord-015021-pol2qm74	5488	20	after	after	IN
cord-015021-pol2qm74	5488	21	tissue	tissue	NN
cord-015021-pol2qm74	5488	22	trauma	trauma	NN
cord-015021-pol2qm74	5488	23	,	,	,
cord-015021-pol2qm74	5488	24	e.g.	e.g.	RB
cord-015021-pol2qm74	5488	25	after	after	IN
cord-015021-pol2qm74	5488	26	major	major	JJ
cord-015021-pol2qm74	5488	27	surgery	surgery	NN
cord-015021-pol2qm74	5488	28	.	.	.
cord-015021-pol2qm74	5489	1	The	the	DT
cord-015021-pol2qm74	5489	2	proteins	protein	NNS
cord-015021-pol2qm74	5489	3	counteract	counteract	VBP
cord-015021-pol2qm74	5489	4	the	the	DT
cord-015021-pol2qm74	5489	5	source	source	NN
cord-015021-pol2qm74	5489	6	of	of	IN
cord-015021-pol2qm74	5489	7	injury	injury	NN
cord-015021-pol2qm74	5489	8	,	,	,
cord-015021-pol2qm74	5489	9	facilitate	facilitate	VB
cord-015021-pol2qm74	5489	10	clearance	clearance	NN
cord-015021-pol2qm74	5489	11	of	of	IN
cord-015021-pol2qm74	5489	12	infectious	infectious	JJ
cord-015021-pol2qm74	5489	13	particles	particle	NNS
cord-015021-pol2qm74	5489	14	by	by	IN
cord-015021-pol2qm74	5489	15	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	5489	16	,	,	,
cord-015021-pol2qm74	5489	17	assist	assist	VB
cord-015021-pol2qm74	5489	18	immune	immune	JJ
cord-015021-pol2qm74	5489	19	responses	response	NNS
cord-015021-pol2qm74	5489	20	and	and	CC
cord-015021-pol2qm74	5489	21	initiate	initiate	VB
cord-015021-pol2qm74	5489	22	wound	wind	VBN
cord-015021-pol2qm74	5489	23	healing	healing	NN
cord-015021-pol2qm74	5489	24	.	.	.
cord-015021-pol2qm74	5490	1	The	the	DT
cord-015021-pol2qm74	5490	2	corresponding	corresponding	JJ
cord-015021-pol2qm74	5490	3	genes	gene	NNS
cord-015021-pol2qm74	5490	4	are	be	VBP
cord-015021-pol2qm74	5490	5	expressed	express	VBN
cord-015021-pol2qm74	5490	6	in	in	IN
cord-015021-pol2qm74	5490	7	liver	liver	NN
cord-015021-pol2qm74	5490	8	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	5490	9	and	and	CC
cord-015021-pol2qm74	5490	10	regulated	regulate	VBN
cord-015021-pol2qm74	5490	11	by	by	IN
cord-015021-pol2qm74	5490	12	the	the	DT
cord-015021-pol2qm74	5490	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5490	14	mediators	mediator	NNS
cord-015021-pol2qm74	5490	15	interleukin	interleukin	NN
cord-015021-pol2qm74	5490	16	1	1	CD
cord-015021-pol2qm74	5490	17	and	and	CC
cord-015021-pol2qm74	5490	18	interleukin	interleukin	NN
cord-015021-pol2qm74	5490	19	6	6	CD
cord-015021-pol2qm74	5490	20	(	(	-LRB-
cord-015021-pol2qm74	5490	21	ILl	ILl	NNP
cord-015021-pol2qm74	5490	22	,	,	,
cord-015021-pol2qm74	5490	23	IL6	IL6	NNP
cord-015021-pol2qm74	5490	24	)	)	-RRB-
cord-015021-pol2qm74	5490	25	.	.	.
cord-015021-pol2qm74	5491	1	Class1	Class1	NNP
cord-015021-pol2qm74	5492	1	acute	acute	JJ
cord-015021-pol2qm74	5492	2	phase	phase	NN
cord-015021-pol2qm74	5492	3	genes	gene	NNS
cord-015021-pol2qm74	5492	4	are	be	VBP
cord-015021-pol2qm74	5492	5	mainly	mainly	RB
cord-015021-pol2qm74	5492	6	controlled	control	VBN
cord-015021-pol2qm74	5492	7	by	by	IN
cord-015021-pol2qm74	5492	8	ILl	ILl	NNS
cord-015021-pol2qm74	5492	9	and	and	CC
cord-015021-pol2qm74	5492	10	by	by	IN
cord-015021-pol2qm74	5492	11	combinations	combination	NNS
cord-015021-pol2qm74	5492	12	of	of	IN
cord-015021-pol2qm74	5492	13	ILl	ILl	NNP
cord-015021-pol2qm74	5492	14	plus	plus	CC
cord-015021-pol2qm74	5492	15	IL6	IL6	NNP
cord-015021-pol2qm74	5492	16	;	;	:
cord-015021-pol2qm74	5492	17	class2	class2	NNP
cord-015021-pol2qm74	5492	18	genes	gene	NNS
cord-015021-pol2qm74	5492	19	mainly	mainly	RB
cord-015021-pol2qm74	5492	20	by	by	IN
cord-015021-pol2qm74	5492	21	ii,6	ii,6	NNP
cord-015021-pol2qm74	5492	22	.	.	.
cord-015021-pol2qm74	5493	1	The	the	DT
cord-015021-pol2qm74	5493	2	human	human	JJ
cord-015021-pol2qm74	5493	3	C	c	NN
cord-015021-pol2qm74	5493	4	-	-	HYPH
cord-015021-pol2qm74	5493	5	reactive	reactive	JJ
cord-015021-pol2qm74	5493	6	protein(CRP	protein(crp	CD
cord-015021-pol2qm74	5493	7	)	)	-RRB-
cord-015021-pol2qm74	5493	8	,	,	,
cord-015021-pol2qm74	5493	9	serum	serum	NN
cord-015021-pol2qm74	5493	10	amyloid	amyloid	NN
cord-015021-pol2qm74	5493	11	A(SAA	A(SAA	NNP
cord-015021-pol2qm74	5493	12	)	)	-RRB-
cord-015021-pol2qm74	5493	13	and	and	CC
cord-015021-pol2qm74	5493	14	complement	complement	VB
cord-015021-pol2qm74	5493	15	C3	C3	NNP
cord-015021-pol2qm74	5493	16	genes	gene	NNS
cord-015021-pol2qm74	5493	17	will	will	MD
cord-015021-pol2qm74	5493	18	be	be	VB
cord-015021-pol2qm74	5493	19	discussed	discuss	VBN
cord-015021-pol2qm74	5493	20	as	as	IN
cord-015021-pol2qm74	5493	21	examples	example	NNS
cord-015021-pol2qm74	5493	22	of	of	IN
cord-015021-pol2qm74	5493	23	class1	class1	NNP
cord-015021-pol2qm74	5493	24	genes	gene	NNS
cord-015021-pol2qm74	5493	25	,	,	,
cord-015021-pol2qm74	5493	26	and	and	CC
cord-015021-pol2qm74	5493	27	rat	rat	NN
cord-015021-pol2qm74	5493	28	c~2	c~2	NNP
cord-015021-pol2qm74	5493	29	macroglobulin	macroglobulin	NNP
cord-015021-pol2qm74	5493	30	as	as	IN
cord-015021-pol2qm74	5493	31	a	a	DT
cord-015021-pol2qm74	5493	32	prototypical	prototypical	JJ
cord-015021-pol2qm74	5493	33	class2	class2	NN
cord-015021-pol2qm74	5493	34	gene	gene	NN
cord-015021-pol2qm74	5493	35	.	.	.
cord-015021-pol2qm74	5494	1	Both	both	DT
cord-015021-pol2qm74	5494	2	classes	class	NNS
cord-015021-pol2qm74	5494	3	of	of	IN
cord-015021-pol2qm74	5494	4	genes	gene	NNS
cord-015021-pol2qm74	5494	5	use	use	VBP
cord-015021-pol2qm74	5494	6	different	different	JJ
cord-015021-pol2qm74	5494	7	types	type	NNS
cord-015021-pol2qm74	5494	8	of	of	IN
cord-015021-pol2qm74	5494	9	¢ytokine	¢ytokine	JJ
cord-015021-pol2qm74	5494	10	response	response	NN
cord-015021-pol2qm74	5494	11	elements	element	NNS
cord-015021-pol2qm74	5494	12	in	in	IN
cord-015021-pol2qm74	5494	13	their	-PRON-	PRP$
cord-015021-pol2qm74	5494	14	promoter	promoter	NN
cord-015021-pol2qm74	5494	15	-	-	HYPH
cord-015021-pol2qm74	5494	16	proximal	proximal	JJ
cord-015021-pol2qm74	5494	17	transcription	transcription	NN
cord-015021-pol2qm74	5494	18	control	control	NN
cord-015021-pol2qm74	5494	19	regions	region	NNS
cord-015021-pol2qm74	5494	20	;	;	:
cord-015021-pol2qm74	5494	21	class1	class1	NN
cord-015021-pol2qm74	5494	22	genes	gene	NNS
cord-015021-pol2qm74	5494	23	use	use	VBP
cord-015021-pol2qm74	5494	24	the	the	DT
cord-015021-pol2qm74	5494	25	transcription	transcription	NN
cord-015021-pol2qm74	5494	26	factor	factor	NN
cord-015021-pol2qm74	5494	27	NF	nf	NN
cord-015021-pol2qm74	5494	28	-	-	HYPH
cord-015021-pol2qm74	5494	29	IL6	IL6	NNP
cord-015021-pol2qm74	5494	30	or	or	CC
cord-015021-pol2qm74	5494	31	C	C	NNP
cord-015021-pol2qm74	5494	32	/	/	SYM
cord-015021-pol2qm74	5494	33	EBP	ebp	NN
cord-015021-pol2qm74	5494	34	as	as	IN
cord-015021-pol2qm74	5494	35	the	the	DT
cord-015021-pol2qm74	5494	36	key	key	JJ
cord-015021-pol2qm74	5494	37	factor	factor	NN
cord-015021-pol2qm74	5494	38	to	to	TO
cord-015021-pol2qm74	5494	39	mediate	mediate	VB
cord-015021-pol2qm74	5494	40	cytokine	cytokine	JJ
cord-015021-pol2qm74	5494	41	responsiveness	responsiveness	NN
cord-015021-pol2qm74	5494	42	;	;	:
cord-015021-pol2qm74	5494	43	class2	class2	NNP
cord-015021-pol2qm74	5494	44	genes	gene	NNS
cord-015021-pol2qm74	5494	45	use	use	VBP
cord-015021-pol2qm74	5494	46	a	a	DT
cord-015021-pol2qm74	5494	47	different	different	JJ
cord-015021-pol2qm74	5494	48	,	,	,
cord-015021-pol2qm74	5494	49	so	so	RB
cord-015021-pol2qm74	5494	50	far	far	RB
cord-015021-pol2qm74	5494	51	unidentified	unidentified	JJ
cord-015021-pol2qm74	5494	52	factor	factor	NN
cord-015021-pol2qm74	5494	53	to	to	TO
cord-015021-pol2qm74	5494	54	achieve	achieve	VB
cord-015021-pol2qm74	5494	55	responsiveness	responsiveness	NN
cord-015021-pol2qm74	5494	56	to	to	IN
cord-015021-pol2qm74	5494	57	IL6	IL6	NNP
cord-015021-pol2qm74	5494	58	.	.	.
cord-015021-pol2qm74	5495	1	Ongoing	ongoing	JJ
cord-015021-pol2qm74	5495	2	efforts	effort	NNS
cord-015021-pol2qm74	5495	3	to	to	TO
cord-015021-pol2qm74	5495	4	purify	purify	VB
cord-015021-pol2qm74	5495	5	this	this	DT
cord-015021-pol2qm74	5495	6	factor	factor	NN
cord-015021-pol2qm74	5495	7	,	,	,
cord-015021-pol2qm74	5495	8	called	call	VBD
cord-015021-pol2qm74	5495	9	the	the	DT
cord-015021-pol2qm74	5495	10	IL6-Response	IL6-Response	NNP
cord-015021-pol2qm74	5495	11	Factor	Factor	NNP
cord-015021-pol2qm74	5495	12	(	(	-LRB-
cord-015021-pol2qm74	5495	13	IL6-RF	il6-rf	NN
cord-015021-pol2qm74	5495	14	)	)	-RRB-
cord-015021-pol2qm74	5495	15	,	,	,
cord-015021-pol2qm74	5495	16	from	from	IN
cord-015021-pol2qm74	5495	17	rat	rat	NN
cord-015021-pol2qm74	5495	18	liver	liver	NN
cord-015021-pol2qm74	5495	19	nuclear	nuclear	JJ
cord-015021-pol2qm74	5495	20	protein	protein	NN
cord-015021-pol2qm74	5495	21	extracts	extract	NNS
cord-015021-pol2qm74	5495	22	will	will	MD
cord-015021-pol2qm74	5495	23	be	be	VB
cord-015021-pol2qm74	5495	24	described	describe	VBN
cord-015021-pol2qm74	5495	25	.	.	.
cord-015021-pol2qm74	5496	1	The	the	DT
cord-015021-pol2qm74	5496	2	IL6-RF	il6-rf	NN
cord-015021-pol2qm74	5496	3	apparently	apparently	RB
cord-015021-pol2qm74	5496	4	mediates	mediate	VBZ
cord-015021-pol2qm74	5496	5	the	the	DT
cord-015021-pol2qm74	5496	6	effects	effect	NNS
cord-015021-pol2qm74	5496	7	of	of	IN
cord-015021-pol2qm74	5496	8	IL6	il6	NN
cord-015021-pol2qm74	5496	9	in	in	IN
cord-015021-pol2qm74	5496	10	a	a	DT
cord-015021-pol2qm74	5496	11	broad	broad	JJ
cord-015021-pol2qm74	5496	12	range	range	NN
cord-015021-pol2qm74	5496	13	of	of	IN
cord-015021-pol2qm74	5496	14	cell	cell	NN
cord-015021-pol2qm74	5496	15	types	type	NNS
cord-015021-pol2qm74	5496	16	,	,	,
cord-015021-pol2qm74	5496	17	including	include	VBG
cord-015021-pol2qm74	5496	18	B	b	NN
cord-015021-pol2qm74	5496	19	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	5496	20	and	and	CC
cord-015021-pol2qm74	5496	21	other	other	JJ
cord-015021-pol2qm74	5496	22	hematopoietic	hematopoietic	JJ
cord-015021-pol2qm74	5496	23	cells	cell	NNS
cord-015021-pol2qm74	5496	24	.	.	.
cord-015021-pol2qm74	5497	1	It	-PRON-	PRP
cord-015021-pol2qm74	5497	2	is	be	VBZ
cord-015021-pol2qm74	5497	3	therefore	therefore	RB
cord-015021-pol2qm74	5497	4	likely	likely	JJ
cord-015021-pol2qm74	5497	5	to	to	TO
cord-015021-pol2qm74	5497	6	be	be	VB
cord-015021-pol2qm74	5497	7	of	of	IN
cord-015021-pol2qm74	5497	8	equal	equal	JJ
cord-015021-pol2qm74	5497	9	general	general	JJ
cord-015021-pol2qm74	5497	10	importance	importance	NN
cord-015021-pol2qm74	5497	11	for	for	IN
cord-015021-pol2qm74	5497	12	gene	gene	NN
cord-015021-pol2qm74	5497	13	regulation	regulation	NN
cord-015021-pol2qm74	5497	14	by	by	IN
cord-015021-pol2qm74	5497	15	IL6	IL6	NNP
cord-015021-pol2qm74	5497	16	as	as	IN
cord-015021-pol2qm74	5497	17	NF	NF	NNP
cord-015021-pol2qm74	5497	18	-	-	HYPH
cord-015021-pol2qm74	5497	19	IL6	il6	NN
cord-015021-pol2qm74	5497	20	.	.	.
cord-015021-pol2qm74	5498	1	The	the	DT
cord-015021-pol2qm74	5498	2	importance	importance	NN
cord-015021-pol2qm74	5498	3	of	of	IN
cord-015021-pol2qm74	5498	4	transcription	transcription	NN
cord-015021-pol2qm74	5498	5	factors	factor	NNS
cord-015021-pol2qm74	5498	6	as	as	IN
cord-015021-pol2qm74	5498	7	potential	potential	JJ
cord-015021-pol2qm74	5498	8	targets	target	NNS
cord-015021-pol2qm74	5498	9	for	for	IN
cord-015021-pol2qm74	5498	10	novel	novel	JJ
cord-015021-pol2qm74	5498	11	bioactive	bioactive	JJ
cord-015021-pol2qm74	5498	12	substances	substance	NNS
cord-015021-pol2qm74	5498	13	and	and	CC
cord-015021-pol2qm74	5498	14	possibly	possibly	RB
cord-015021-pol2qm74	5498	15	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	5498	16	agents	agent	NNS
cord-015021-pol2qm74	5498	17	will	will	MD
cord-015021-pol2qm74	5498	18	be	be	VB
cord-015021-pol2qm74	5498	19	discussed	discuss	VBN
cord-015021-pol2qm74	5498	20	with	with	IN
cord-015021-pol2qm74	5498	21	the	the	DT
cord-015021-pol2qm74	5498	22	help	help	NN
cord-015021-pol2qm74	5498	23	of	of	IN
cord-015021-pol2qm74	5498	24	several	several	JJ
cord-015021-pol2qm74	5498	25	recent	recent	JJ
cord-015021-pol2qm74	5498	26	examples	example	NNS
cord-015021-pol2qm74	5498	27	.	.	.
cord-015021-pol2qm74	5499	1	New	new	JJ
cord-015021-pol2qm74	5499	2	methods	method	NNS
cord-015021-pol2qm74	5499	3	for	for	IN
cord-015021-pol2qm74	5499	4	altering	alter	VBG
cord-015021-pol2qm74	5499	5	the	the	DT
cord-015021-pol2qm74	5499	6	germ	germ	NN
cord-015021-pol2qm74	5499	7	lines	line	NNS
cord-015021-pol2qm74	5499	8	of	of	IN
cord-015021-pol2qm74	5499	9	mice	mouse	NNS
cord-015021-pol2qm74	5499	10	provide	provide	VBP
cord-015021-pol2qm74	5499	11	powerful	powerful	JJ
cord-015021-pol2qm74	5499	12	tools	tool	NNS
cord-015021-pol2qm74	5499	13	for	for	IN
cord-015021-pol2qm74	5499	14	understanding	understand	VBG
cord-015021-pol2qm74	5499	15	the	the	DT
cord-015021-pol2qm74	5499	16	roles	role	NNS
cord-015021-pol2qm74	5499	17	of	of	IN
cord-015021-pol2qm74	5499	18	individual	individual	JJ
cord-015021-pol2qm74	5499	19	genes	gene	NNS
cord-015021-pol2qm74	5499	20	in	in	IN
cord-015021-pol2qm74	5499	21	normal	normal	JJ
cord-015021-pol2qm74	5499	22	and	and	CC
cord-015021-pol2qm74	5499	23	pathological	pathological	JJ
cord-015021-pol2qm74	5499	24	processes	process	NNS
cord-015021-pol2qm74	5499	25	,	,	,
cord-015021-pol2qm74	5499	26	and	and	CC
cord-015021-pol2qm74	5499	27	for	for	IN
cord-015021-pol2qm74	5499	28	reproducing	reproduce	VBG
cord-015021-pol2qm74	5499	29	specific	specific	JJ
cord-015021-pol2qm74	5499	30	genetic	genetic	JJ
cord-015021-pol2qm74	5499	31	mutations	mutation	NNS
cord-015021-pol2qm74	5499	32	that	that	WDT
cord-015021-pol2qm74	5499	33	result	result	VBP
cord-015021-pol2qm74	5499	34	in	in	IN
cord-015021-pol2qm74	5499	35	congenital	congenital	JJ
cord-015021-pol2qm74	5499	36	disease	disease	NN
cord-015021-pol2qm74	5499	37	.	.	.
cord-015021-pol2qm74	5500	1	Three	three	CD
cord-015021-pol2qm74	5500	2	approaches	approach	NNS
cord-015021-pol2qm74	5500	3	will	will	MD
cord-015021-pol2qm74	5500	4	be	be	VB
cord-015021-pol2qm74	5500	5	discussed	discuss	VBN
cord-015021-pol2qm74	5500	6	.	.	.
cord-015021-pol2qm74	5501	1	Conventional	conventional	JJ
cord-015021-pol2qm74	5501	2	transgeulc	transgeulc	NN
cord-015021-pol2qm74	5501	3	mice	mouse	NNS
cord-015021-pol2qm74	5501	4	are	be	VBP
cord-015021-pol2qm74	5501	5	frequently	frequently	RB
cord-015021-pol2qm74	5501	6	constructed	construct	VBN
cord-015021-pol2qm74	5501	7	using	use	VBG
cord-015021-pol2qm74	5501	8	artificial	artificial	JJ
cord-015021-pol2qm74	5501	9	transgenes	transgene	NNS
cord-015021-pol2qm74	5501	10	that	that	WDT
cord-015021-pol2qm74	5501	11	express	express	VBP
cord-015021-pol2qm74	5501	12	genes	gene	NNS
cord-015021-pol2qm74	5501	13	from	from	IN
cord-015021-pol2qm74	5501	14	a	a	DT
cord-015021-pol2qm74	5501	15	promoter	promoter	NN
cord-015021-pol2qm74	5501	16	other	other	JJ
cord-015021-pol2qm74	5501	17	than	than	IN
cord-015021-pol2qm74	5501	18	the	the	DT
cord-015021-pol2qm74	5501	19	normal	normal	JJ
cord-015021-pol2qm74	5501	20	gene	gene	NN
cord-015021-pol2qm74	5501	21	promoter	promoter	NN
cord-015021-pol2qm74	5501	22	.	.	.
cord-015021-pol2qm74	5502	1	This	this	DT
cord-015021-pol2qm74	5502	2	paradigm	paradigm	NN
cord-015021-pol2qm74	5502	3	is	be	VBZ
cord-015021-pol2qm74	5502	4	used	use	VBN
cord-015021-pol2qm74	5502	5	to	to	TO
cord-015021-pol2qm74	5502	6	produce	produce	VB
cord-015021-pol2qm74	5502	7	very	very	RB
cord-015021-pol2qm74	5502	8	high	high	JJ
cord-015021-pol2qm74	5502	9	levels	level	NNS
cord-015021-pol2qm74	5502	10	of	of	IN
cord-015021-pol2qm74	5502	11	a	a	DT
cord-015021-pol2qm74	5502	12	gene	gene	NN
cord-015021-pol2qm74	5502	13	product	product	NN
cord-015021-pol2qm74	5502	14	,	,	,
cord-015021-pol2qm74	5502	15	for	for	IN
cord-015021-pol2qm74	5502	16	example	example	NN
cord-015021-pol2qm74	5502	17	,	,	,
cord-015021-pol2qm74	5502	18	with	with	IN
cord-015021-pol2qm74	5502	19	a	a	DT
cord-015021-pol2qm74	5502	20	viral	viral	JJ
cord-015021-pol2qm74	5502	21	promoter	promoter	NN
cord-015021-pol2qm74	5502	22	,	,	,
cord-015021-pol2qm74	5502	23	or	or	CC
cord-015021-pol2qm74	5502	24	to	to	TO
cord-015021-pol2qm74	5502	25	attempt	attempt	VB
cord-015021-pol2qm74	5502	26	to	to	TO
cord-015021-pol2qm74	5502	27	regulate	regulate	VB
cord-015021-pol2qm74	5502	28	gene	gene	NN
cord-015021-pol2qm74	5502	29	expression	expression	NN
cord-015021-pol2qm74	5502	30	using	use	VBG
cord-015021-pol2qm74	5502	31	an	an	DT
cord-015021-pol2qm74	5502	32	inducible	inducible	JJ
cord-015021-pol2qm74	5502	33	promoter	promoter	NN
cord-015021-pol2qm74	5502	34	.	.	.
cord-015021-pol2qm74	5503	1	Alternatively	alternatively	RB
cord-015021-pol2qm74	5503	2	,	,	,
cord-015021-pol2qm74	5503	3	normal	normal	JJ
cord-015021-pol2qm74	5503	4	promoter	promoter	NN
cord-015021-pol2qm74	5503	5	sequences	sequence	NNS
cord-015021-pol2qm74	5503	6	can	can	MD
cord-015021-pol2qm74	5503	7	be	be	VB
cord-015021-pol2qm74	5503	8	hooked	hook	VBN
cord-015021-pol2qm74	5503	9	to	to	IN
cord-015021-pol2qm74	5503	10	a	a	DT
cord-015021-pol2qm74	5503	11	gene	gene	NN
cord-015021-pol2qm74	5503	12	whose	whose	WP$
cord-015021-pol2qm74	5503	13	expression	expression	NN
cord-015021-pol2qm74	5503	14	is	be	VBZ
cord-015021-pol2qm74	5503	15	lethal	lethal	JJ
cord-015021-pol2qm74	5503	16	to	to	IN
cord-015021-pol2qm74	5503	17	the	the	DT
cord-015021-pol2qm74	5503	18	cell	cell	NN
cord-015021-pol2qm74	5503	19	(	(	-LRB-
cord-015021-pol2qm74	5503	20	e.g.	e.g.	RB
cord-015021-pol2qm74	5503	21	,	,	,
cord-015021-pol2qm74	5503	22	diptheria	diptheria	NN
cord-015021-pol2qm74	5503	23	toxin	toxin	NN
cord-015021-pol2qm74	5503	24	A	a	DT
cord-015021-pol2qm74	5503	25	chain	chain	NN
cord-015021-pol2qm74	5503	26	)	)	-RRB-
cord-015021-pol2qm74	5503	27	to	to	TO
cord-015021-pol2qm74	5503	28	ablate	ablate	VB
cord-015021-pol2qm74	5503	29	all	all	DT
cord-015021-pol2qm74	5503	30	cells	cell	NNS
cord-015021-pol2qm74	5503	31	expressing	express	VBG
cord-015021-pol2qm74	5503	32	that	that	DT
cord-015021-pol2qm74	5503	33	gene	gene	NN
cord-015021-pol2qm74	5503	34	.	.	.
cord-015021-pol2qm74	5504	1	Another	another	DT
cord-015021-pol2qm74	5504	2	approach	approach	NN
cord-015021-pol2qm74	5504	3	uses	use	VBZ
cord-015021-pol2qm74	5504	4	an	an	DT
cord-015021-pol2qm74	5504	5	intact	intact	JJ
cord-015021-pol2qm74	5504	6	gene	gene	NN
cord-015021-pol2qm74	5504	7	with	with	IN
cord-015021-pol2qm74	5504	8	its	-PRON-	PRP$
cord-015021-pol2qm74	5504	9	normal	normal	JJ
cord-015021-pol2qm74	5504	10	regulatory	regulatory	JJ
cord-015021-pol2qm74	5504	11	sequences	sequence	NNS
cord-015021-pol2qm74	5504	12	.	.	.
cord-015021-pol2qm74	5505	1	Here	here	RB
cord-015021-pol2qm74	5505	2	,	,	,
cord-015021-pol2qm74	5505	3	an	an	DT
cord-015021-pol2qm74	5505	4	elevated	elevated	JJ
cord-015021-pol2qm74	5505	5	level	level	NN
cord-015021-pol2qm74	5505	6	of	of	IN
cord-015021-pol2qm74	5505	7	the	the	DT
cord-015021-pol2qm74	5505	8	gene	gene	NN
cord-015021-pol2qm74	5505	9	product	product	NN
cord-015021-pol2qm74	5505	10	is	be	VBZ
cord-015021-pol2qm74	5505	11	delivered	deliver	VBN
cord-015021-pol2qm74	5505	12	from	from	IN
cord-015021-pol2qm74	5505	13	the	the	DT
cord-015021-pol2qm74	5505	14	correct	correct	JJ
cord-015021-pol2qm74	5505	15	cells	cell	NNS
cord-015021-pol2qm74	5505	16	in	in	IN
cord-015021-pol2qm74	5505	17	the	the	DT
cord-015021-pol2qm74	5505	18	correct	correct	JJ
cord-015021-pol2qm74	5505	19	tissues	tissue	NNS
cord-015021-pol2qm74	5505	20	at	at	IN
cord-015021-pol2qm74	5505	21	the	the	DT
cord-015021-pol2qm74	5505	22	correct	correct	JJ
cord-015021-pol2qm74	5505	23	developmental	developmental	JJ
cord-015021-pol2qm74	5505	24	stages	stage	NNS
cord-015021-pol2qm74	5505	25	or	or	CC
cord-015021-pol2qm74	5505	26	in	in	IN
cord-015021-pol2qm74	5505	27	response	response	NN
cord-015021-pol2qm74	5505	28	to	to	IN
cord-015021-pol2qm74	5505	29	natural	natural	JJ
cord-015021-pol2qm74	5505	30	signals	signal	NNS
cord-015021-pol2qm74	5505	31	.	.	.
cord-015021-pol2qm74	5506	1	This	this	DT
cord-015021-pol2qm74	5506	2	approach	approach	NN
cord-015021-pol2qm74	5506	3	has	have	VBZ
cord-015021-pol2qm74	5506	4	been	be	VBN
cord-015021-pol2qm74	5506	5	refered	refer	VBN
cord-015021-pol2qm74	5506	6	to	to	IN
cord-015021-pol2qm74	5506	7	as	as	IN
cord-015021-pol2qm74	5506	8	"	"	``
cord-015021-pol2qm74	5506	9	genetic	genetic	JJ
cord-015021-pol2qm74	5506	10	pharmacology	pharmacology	NN
cord-015021-pol2qm74	5506	11	,	,	,
cord-015021-pol2qm74	5506	12	"	"	''
cord-015021-pol2qm74	5506	13	and	and	CC
cord-015021-pol2qm74	5506	14	provides	provide	VBZ
cord-015021-pol2qm74	5506	15	a	a	DT
cord-015021-pol2qm74	5506	16	precise	precise	JJ
cord-015021-pol2qm74	5506	17	delivery	delivery	NN
cord-015021-pol2qm74	5506	18	of	of	IN
cord-015021-pol2qm74	5506	19	the	the	DT
cord-015021-pol2qm74	5506	20	gene	gene	NN
cord-015021-pol2qm74	5506	21	product	product	NN
cord-015021-pol2qm74	5506	22	to	to	IN
cord-015021-pol2qm74	5506	23	the	the	DT
cord-015021-pol2qm74	5506	24	target	target	NN
cord-015021-pol2qm74	5506	25	.	.	.
cord-015021-pol2qm74	5507	1	However	however	RB
cord-015021-pol2qm74	5507	2	,	,	,
cord-015021-pol2qm74	5507	3	to	to	TO
cord-015021-pol2qm74	5507	4	be	be	VB
cord-015021-pol2qm74	5507	5	most	most	RBS
cord-015021-pol2qm74	5507	6	effective	effective	JJ
cord-015021-pol2qm74	5507	7	,	,	,
cord-015021-pol2qm74	5507	8	the	the	DT
cord-015021-pol2qm74	5507	9	transgene	transgene	NN
cord-015021-pol2qm74	5507	10	should	should	MD
cord-015021-pol2qm74	5507	11	contain	contain	VB
cord-015021-pol2qm74	5507	12	arl	arl	NNP
cord-015021-pol2qm74	5507	13	regulatory	regulatory	JJ
cord-015021-pol2qm74	5507	14	sequences	sequence	NNS
cord-015021-pol2qm74	5507	15	as	as	IN
cord-015021-pol2qm74	5507	16	welt	welt	NN
cord-015021-pol2qm74	5507	17	as	as	IN
cord-015021-pol2qm74	5507	18	the	the	DT
cord-015021-pol2qm74	5507	19	entire	entire	JJ
cord-015021-pol2qm74	5507	20	genomic	genomic	JJ
cord-015021-pol2qm74	5507	21	segment	segment	NN
cord-015021-pol2qm74	5507	22	containing	contain	VBG
cord-015021-pol2qm74	5507	23	gene	gene	NN
cord-015021-pol2qm74	5507	24	coding	code	VBG
cord-015021-pol2qm74	5507	25	regions	region	NNS
cord-015021-pol2qm74	5507	26	.	.	.
cord-015021-pol2qm74	5508	1	The	the	DT
cord-015021-pol2qm74	5508	2	introduction	introduction	NN
cord-015021-pol2qm74	5508	3	of	of	IN
cord-015021-pol2qm74	5508	4	conventional	conventional	JJ
cord-015021-pol2qm74	5508	5	transgenes	transgene	NNS
cord-015021-pol2qm74	5508	6	is	be	VBZ
cord-015021-pol2qm74	5508	7	limited	limit	VBN
cord-015021-pol2qm74	5508	8	to	to	IN
cord-015021-pol2qm74	5508	9	roughly	roughly	RB
cord-015021-pol2qm74	5508	10	50	50	CD
cord-015021-pol2qm74	5508	11	kilobases	kilobase	NNS
cord-015021-pol2qm74	5508	12	,	,	,
cord-015021-pol2qm74	5508	13	while	while	IN
cord-015021-pol2qm74	5508	14	genes	gene	NNS
cord-015021-pol2qm74	5508	15	containing	contain	VBG
cord-015021-pol2qm74	5508	16	all	all	DT
cord-015021-pol2qm74	5508	17	regulatory	regulatory	JJ
cord-015021-pol2qm74	5508	18	sequences	sequence	NNS
cord-015021-pol2qm74	5508	19	frequently	frequently	RB
cord-015021-pol2qm74	5508	20	stretch	stretch	VBP
cord-015021-pol2qm74	5508	21	over	over	IN
cord-015021-pol2qm74	5508	22	dozens	dozen	NNS
cord-015021-pol2qm74	5508	23	or	or	CC
cord-015021-pol2qm74	5508	24	even	even	RB
cord-015021-pol2qm74	5508	25	hundreds	hundred	NNS
cord-015021-pol2qm74	5508	26	of	of	IN
cord-015021-pol2qm74	5508	27	kilobases	kilobase	NNS
cord-015021-pol2qm74	5508	28	.	.	.
cord-015021-pol2qm74	5509	1	To	to	TO
cord-015021-pol2qm74	5509	2	overcome	overcome	VB
cord-015021-pol2qm74	5509	3	this	this	DT
cord-015021-pol2qm74	5509	4	problem	problem	NN
cord-015021-pol2qm74	5509	5	,	,	,
cord-015021-pol2qm74	5509	6	procedures	procedure	NNS
cord-015021-pol2qm74	5509	7	have	have	VBP
cord-015021-pol2qm74	5509	8	been	be	VBN
cord-015021-pol2qm74	5509	9	developed	develop	VBN
cord-015021-pol2qm74	5509	10	recently	recently	RB
cord-015021-pol2qm74	5509	11	to	to	TO
cord-015021-pol2qm74	5509	12	introduce	introduce	VB
cord-015021-pol2qm74	5509	13	yeast	yeast	NN
cord-015021-pol2qm74	5509	14	artificial	artificial	JJ
cord-015021-pol2qm74	5509	15	chromosomes	chromosome	NNS
cord-015021-pol2qm74	5509	16	(	(	-LRB-
cord-015021-pol2qm74	5509	17	YACs	YACs	NNP
cord-015021-pol2qm74	5509	18	)	)	-RRB-
cord-015021-pol2qm74	5509	19	into	into	IN
cord-015021-pol2qm74	5509	20	mouse	mouse	NN
cord-015021-pol2qm74	5509	21	embryonic	embryonic	JJ
cord-015021-pol2qm74	5509	22	stem	stem	NN
cord-015021-pol2qm74	5509	23	(	(	-LRB-
cord-015021-pol2qm74	5509	24	ES	ES	NNP
cord-015021-pol2qm74	5509	25	)	)	-RRB-
cord-015021-pol2qm74	5509	26	cells	cell	NNS
cord-015021-pol2qm74	5509	27	.	.	.
cord-015021-pol2qm74	5510	1	YACs	yac	NNS
cord-015021-pol2qm74	5510	2	can	can	MD
cord-015021-pol2qm74	5510	3	include	include	VB
cord-015021-pol2qm74	5510	4	over	over	IN
cord-015021-pol2qm74	5510	5	2	2	CD
cord-015021-pol2qm74	5510	6	Mb	Mb	NNS
cord-015021-pol2qm74	5510	7	of	of	IN
cord-015021-pol2qm74	5510	8	human	human	JJ
cord-015021-pol2qm74	5510	9	DNA	dna	NN
cord-015021-pol2qm74	5510	10	,	,	,
cord-015021-pol2qm74	5510	11	large	large	JJ
cord-015021-pol2qm74	5510	12	enough	enough	RB
cord-015021-pol2qm74	5510	13	to	to	TO
cord-015021-pol2qm74	5510	14	encompass	encompass	VB
cord-015021-pol2qm74	5510	15	the	the	DT
cord-015021-pol2qm74	5510	16	largest	large	JJS
cord-015021-pol2qm74	5510	17	known	know	VBN
cord-015021-pol2qm74	5510	18	human	human	JJ
cord-015021-pol2qm74	5510	19	genes	gene	NNS
cord-015021-pol2qm74	5510	20	.	.	.
cord-015021-pol2qm74	5511	1	ES	ES	NNP
cord-015021-pol2qm74	5511	2	cells	cell	NNS
cord-015021-pol2qm74	5511	3	are	be	VBP
cord-015021-pol2qm74	5511	4	also	also	RB
cord-015021-pol2qm74	5511	5	useful	useful	JJ
cord-015021-pol2qm74	5511	6	for	for	IN
cord-015021-pol2qm74	5511	7	targeted	target	VBN
cord-015021-pol2qm74	5511	8	gene	gene	NN
cord-015021-pol2qm74	5511	9	deletions	deletion	NNS
cord-015021-pol2qm74	5511	10	and	and	CC
cord-015021-pol2qm74	5511	11	mutations	mutation	NNS
cord-015021-pol2qm74	5511	12	.	.	.
cord-015021-pol2qm74	5512	1	Homologous	homologous	JJ
cord-015021-pol2qm74	5512	2	recombination	recombination	NN
cord-015021-pol2qm74	5512	3	can	can	MD
cord-015021-pol2qm74	5512	4	be	be	VB
cord-015021-pol2qm74	5512	5	targeted	target	VBN
cord-015021-pol2qm74	5512	6	to	to	IN
cord-015021-pol2qm74	5512	7	any	any	DT
cord-015021-pol2qm74	5512	8	known	know	VBN
cord-015021-pol2qm74	5512	9	gene	gene	NN
cord-015021-pol2qm74	5512	10	in	in	IN
cord-015021-pol2qm74	5512	11	ES	ES	NNP
cord-015021-pol2qm74	5512	12	cells	cell	NNS
cord-015021-pol2qm74	5512	13	.	.	.
cord-015021-pol2qm74	5513	1	When	when	WRB
cord-015021-pol2qm74	5513	2	these	these	DT
cord-015021-pol2qm74	5513	3	modified	modify	VBN
cord-015021-pol2qm74	5513	4	cells	cell	NNS
cord-015021-pol2qm74	5513	5	are	be	VBP
cord-015021-pol2qm74	5513	6	injected	inject	VBN
cord-015021-pol2qm74	5513	7	into	into	IN
cord-015021-pol2qm74	5513	8	a	a	DT
cord-015021-pol2qm74	5513	9	mouse	mouse	NN
cord-015021-pol2qm74	5513	10	blastocyst	blastocyst	NN
cord-015021-pol2qm74	5513	11	,	,	,
cord-015021-pol2qm74	5513	12	they	-PRON-	PRP
cord-015021-pol2qm74	5513	13	can	can	MD
cord-015021-pol2qm74	5513	14	be	be	VB
cord-015021-pol2qm74	5513	15	incorporated	incorporate	VBN
cord-015021-pol2qm74	5513	16	into	into	IN
cord-015021-pol2qm74	5513	17	all	all	DT
cord-015021-pol2qm74	5513	18	tissues	tissue	NNS
cord-015021-pol2qm74	5513	19	of	of	IN
cord-015021-pol2qm74	5513	20	the	the	DT
cord-015021-pol2qm74	5513	21	resulting	result	VBG
cord-015021-pol2qm74	5513	22	mouse	mouse	NN
cord-015021-pol2qm74	5513	23	,	,	,
cord-015021-pol2qm74	5513	24	including	include	VBG
cord-015021-pol2qm74	5513	25	germ	germ	NN
cord-015021-pol2qm74	5513	26	cells	cell	NNS
cord-015021-pol2qm74	5513	27	,	,	,
cord-015021-pol2qm74	5513	28	so	so	IN
cord-015021-pol2qm74	5513	29	subsequent	subsequent	JJ
cord-015021-pol2qm74	5513	30	generations	generation	NNS
cord-015021-pol2qm74	5513	31	will	will	MD
cord-015021-pol2qm74	5513	32	pass	pass	VB
cord-015021-pol2qm74	5513	33	the	the	DT
cord-015021-pol2qm74	5513	34	genetic	genetic	JJ
cord-015021-pol2qm74	5513	35	modification	modification	NN
cord-015021-pol2qm74	5513	36	as	as	IN
cord-015021-pol2qm74	5513	37	an	an	DT
cord-015021-pol2qm74	5513	38	inherited	inherit	VBN
cord-015021-pol2qm74	5513	39	trait	trait	NN
cord-015021-pol2qm74	5513	40	.	.	.
cord-015021-pol2qm74	5514	1	Assessment	assessment	NN
cord-015021-pol2qm74	5514	2	of	of	IN
cord-015021-pol2qm74	5514	3	the	the	DT
cord-015021-pol2qm74	5514	4	effects	effect	NNS
cord-015021-pol2qm74	5514	5	of	of	IN
cord-015021-pol2qm74	5514	6	a	a	DT
cord-015021-pol2qm74	5514	7	null	null	JJ
cord-015021-pol2qm74	5514	8	allele	allele	NN
cord-015021-pol2qm74	5514	9	on	on	IN
cord-015021-pol2qm74	5514	10	development	development	NN
cord-015021-pol2qm74	5514	11	can	can	MD
cord-015021-pol2qm74	5514	12	provide	provide	VB
cord-015021-pol2qm74	5514	13	valuable	valuable	JJ
cord-015021-pol2qm74	5514	14	insights	insight	NNS
cord-015021-pol2qm74	5514	15	into	into	IN
cord-015021-pol2qm74	5514	16	its	-PRON-	PRP$
cord-015021-pol2qm74	5514	17	normal	normal	JJ
cord-015021-pol2qm74	5514	18	role	role	NN
cord-015021-pol2qm74	5514	19	.	.	.
cord-015021-pol2qm74	5515	1	Ultimately	ultimately	RB
cord-015021-pol2qm74	5515	2	,	,	,
cord-015021-pol2qm74	5515	3	these	these	DT
cord-015021-pol2qm74	5515	4	technologies	technology	NNS
cord-015021-pol2qm74	5515	5	may	may	MD
cord-015021-pol2qm74	5515	6	be	be	VB
cord-015021-pol2qm74	5515	7	adapted	adapt	VBN
cord-015021-pol2qm74	5515	8	to	to	IN
cord-015021-pol2qm74	5515	9	human	human	JJ
cord-015021-pol2qm74	5515	10	cells	cell	NNS
cord-015021-pol2qm74	5515	11	-not	-not	:
cord-015021-pol2qm74	5515	12	for	for	IN
cord-015021-pol2qm74	5515	13	embryonic	embryonic	JJ
cord-015021-pol2qm74	5515	14	intervention	intervention	NN
cord-015021-pol2qm74	5515	15	,	,	,
cord-015021-pol2qm74	5515	16	but	but	CC
cord-015021-pol2qm74	5515	17	to	to	TO
cord-015021-pol2qm74	5515	18	provide	provide	VB
cord-015021-pol2qm74	5515	19	modified	modify	VBN
cord-015021-pol2qm74	5515	20	stem	stem	NN
cord-015021-pol2qm74	5515	21	cells	cell	NNS
cord-015021-pol2qm74	5515	22	for	for	IN
cord-015021-pol2qm74	5515	23	various	various	JJ
cord-015021-pol2qm74	5515	24	tissues	tissue	NNS
cord-015021-pol2qm74	5515	25	(	(	-LRB-
cord-015021-pol2qm74	5515	26	e.g.	e.g.	RB
cord-015021-pol2qm74	5515	27	,	,	,
cord-015021-pol2qm74	5515	28	gut	gut	NN
cord-015021-pol2qm74	5515	29	,	,	,
cord-015021-pol2qm74	5515	30	eye	eye	NN
cord-015021-pol2qm74	5515	31	,	,	,
cord-015021-pol2qm74	5515	32	hematopoietic	hematopoietic	JJ
cord-015021-pol2qm74	5515	33	system	system	NN
cord-015021-pol2qm74	5515	34	)	)	-RRB-
cord-015021-pol2qm74	5515	35	which	which	WDT
cord-015021-pol2qm74	5515	36	could	could	MD
cord-015021-pol2qm74	5515	37	then	then	RB
cord-015021-pol2qm74	5515	38	be	be	VB
cord-015021-pol2qm74	5515	39	applied	apply	VBN
cord-015021-pol2qm74	5515	40	to	to	IN
cord-015021-pol2qm74	5515	41	somatic	somatic	JJ
cord-015021-pol2qm74	5515	42	therapies	therapy	NNS
cord-015021-pol2qm74	5515	43	.	.	.
cord-015021-pol2qm74	5516	1	with	with	IN
cord-015021-pol2qm74	5516	2	major	major	JJ
cord-015021-pol2qm74	5516	3	illness	illness	NN
cord-015021-pol2qm74	5516	4	/	/	SYM
cord-015021-pol2qm74	5516	5	injury	injury	NN
cord-015021-pol2qm74	5516	6	that	that	WDT
cord-015021-pol2qm74	5516	7	respirswy	respirswy	NNP
cord-015021-pol2qm74	5516	8	faihne	faihne	NNP
cord-015021-pol2qm74	5516	9	fi'equently	fi'equently	NNP
cord-015021-pol2qm74	5516	10	followed	follow	VBD
cord-015021-pol2qm74	5516	11	sepsis	sepsis	NN
cord-015021-pol2qm74	5516	12	,	,	,
cord-015021-pol2qm74	5516	13	Tilney	Tilney	NNP
cord-015021-pol2qm74	5516	14	el	el	NNP
cord-015021-pol2qm74	5516	15	al	al	NNP
cord-015021-pol2qm74	5516	16	nse	nse	NNP
cord-015021-pol2qm74	5516	17	,	,	,
cord-015021-pol2qm74	5516	18	d	d	NNP
cord-015021-pol2qm74	5516	19	the	the	DT
cord-015021-pol2qm74	5516	20	term	term	NN
cord-015021-pol2qm74	5516	21	"	"	``
cord-015021-pol2qm74	5516	22	soqueutial	soqueutial	JJ
cord-015021-pol2qm74	5516	23	syste~	syste~	NN
cord-015021-pol2qm74	5516	24	failure	failure	NN
cord-015021-pol2qm74	5516	25	"	"	''
cord-015021-pol2qm74	5516	26	for	for	IN
cord-015021-pol2qm74	5516	27	patients	patient	NNS
cord-015021-pol2qm74	5516	28	with	with	IN
cord-015021-pol2qm74	5516	29	renal	renal	JJ
cord-015021-pol2qm74	5516	30	failure	failure	NN
cord-015021-pol2qm74	5516	31	after	after	IN
cord-015021-pol2qm74	5516	32	Solmir	Solmir	NNP
cord-015021-pol2qm74	5516	33	of	of	IN
cord-015021-pol2qm74	5516	34	ruptured	ruptured	JJ
cord-015021-pol2qm74	5516	35	abdominal	abdominal	JJ
cord-015021-pol2qm74	5516	36	aortic	aortic	NN
cord-015021-pol2qm74	5517	1	~aeurysms	~aeurysms	.
cord-015021-pol2qm74	5518	1	,	,	,
cord-015021-pol2qm74	5518	2	I	-PRON-	PRP
cord-015021-pol2qm74	5518	3	then	then	RB
cord-015021-pol2qm74	5518	4	reviewed	review	VBD
cord-015021-pol2qm74	5518	5	our	-PRON-	PRP$
cord-015021-pol2qm74	5518	6	experiences	experience	NNS
cord-015021-pol2qm74	5518	7	after	after	IN
cord-015021-pol2qm74	5518	8	inju~	inju~	NN
cord-015021-pol2qm74	5518	9	and	and	CC
cord-015021-pol2qm74	5518	10	oporstion	oporstion	NN
cord-015021-pol2qm74	5518	11	and	and	CC
cord-015021-pol2qm74	5518	12	suggested	suggest	VBD
cord-015021-pol2qm74	5518	13	that	that	IN
cord-015021-pol2qm74	5518	14	multiple	multiple	JJ
cord-015021-pol2qm74	5518	15	,	,	,
cord-015021-pol2qm74	5518	16	progsesslve	progsesslve	JJ
cord-015021-pol2qm74	5518	17	or	or	CC
cord-015021-pol2qm74	5518	18	sequential	sequential	JJ
cord-015021-pol2qm74	5518	19	systems	system	NNS
cord-015021-pol2qm74	5518	20	or	or	CC
cord-015021-pol2qm74	5518	21	organ	organ	NN
cord-015021-pol2qm74	5518	22	failure	failure	NN
cord-015021-pol2qm74	5518	23	was	be	VBD
cord-015021-pol2qm74	5518	24	a	a	DT
cord-015021-pol2qm74	5518	25	syndrome	syndrome	NN
cord-015021-pol2qm74	5518	26	to	to	TO
cord-015021-pol2qm74	5518	27	be	be	VB
cord-015021-pol2qm74	5518	28	reckoned	reckon	VBN
cord-015021-pol2qm74	5518	29	with	with	IN
cord-015021-pol2qm74	5518	30	in	in	IN
cord-015021-pol2qm74	5518	31	the	the	DT
cord-015021-pol2qm74	5518	32	,	,	,
cord-015021-pol2qm74	5518	33	70	70	CD
cord-015021-pol2qm74	5518	34	's	's	POS
cord-015021-pol2qm74	5518	35	.	.	.
cord-015021-pol2qm74	5519	1	Eiseman	Eiseman	NNP
cord-015021-pol2qm74	5519	2	et	et	NNP
cord-015021-pol2qm74	5519	3	al	al	NNP
cord-015021-pol2qm74	5519	4	then	then	RB
cord-015021-pol2qm74	5519	5	wrote	write	VBD
cord-015021-pol2qm74	5519	6	about	about	IN
cord-015021-pol2qm74	5519	7	"	"	``
cord-015021-pol2qm74	5519	8	multiple	multiple	JJ
cord-015021-pol2qm74	5519	9	organ	organ	NN
cord-015021-pol2qm74	5519	10	failure	failure	NN
cord-015021-pol2qm74	5519	11	"	"	''
cord-015021-pol2qm74	5519	12	,	,	,
cord-015021-pol2qm74	5519	13	especially	especially	RB
cord-015021-pol2qm74	5519	14	with	with	IN
cord-015021-pol2qm74	5519	15	liver	liver	NN
cord-015021-pol2qm74	5519	16	failure	failure	NN
cord-015021-pol2qm74	5519	17	.	.	.
cord-015021-pol2qm74	5520	1	Polk	Polk	NNP
cord-015021-pol2qm74	5520	2	el	el	NNP
cord-015021-pol2qm74	5520	3	M	M	NNP
cord-015021-pol2qm74	5520	4	found	find	VBD
cord-015021-pol2qm74	5520	5	that	that	IN
cord-015021-pol2qm74	5520	6	renmte	renmte	NNP
cord-015021-pol2qm74	5520	7	orgau	orgau	NNP
cord-015021-pol2qm74	5520	8	failure	failure	NN
cord-015021-pol2qm74	5520	9	often	often	RB
cord-015021-pol2qm74	5520	10	signalled	signal	VBD
cord-015021-pol2qm74	5520	11	occult	occult	JJ
cord-015021-pol2qm74	5520	12	anita	anita	NNP
cord-015021-pol2qm74	5520	13	-	-	HYPH
cord-015021-pol2qm74	5520	14	abdominal	abdominal	JJ
cord-015021-pol2qm74	5520	15	infection	infection	NN
cord-015021-pol2qm74	5520	16	.	.	.
cord-015021-pol2qm74	5521	1	Fry	Fry	NNP
cord-015021-pol2qm74	5521	2	et	et	NNP
cord-015021-pol2qm74	5521	3	al	al	NNP
cord-015021-pol2qm74	5521	4	ampbasized	ampbasize	VBD
cord-015021-pol2qm74	5521	5	the	the	DT
cord-015021-pol2qm74	5521	6	role	role	NN
cord-015021-pol2qm74	5521	7	of	of	IN
cord-015021-pol2qm74	5521	8	uncontrolled	uncontrolled	JJ
cord-015021-pol2qm74	5521	9	infection	infection	NN
cord-015021-pol2qm74	5521	10	in	in	IN
cord-015021-pol2qm74	5521	11	organ	organ	NN
cord-015021-pol2qm74	5521	12	failure	failure	NN
cord-015021-pol2qm74	5521	13	,	,	,
cord-015021-pol2qm74	5521	14	Border	Border	NNP
cord-015021-pol2qm74	5521	15	et	et	NNP
cord-015021-pol2qm74	5521	16	aI	aI	NNP
cord-015021-pol2qm74	5521	17	described	describe	VBD
cord-015021-pol2qm74	5521	18	metabolic	metabolic	JJ
cord-015021-pol2qm74	5521	19	alterations	alteration	NNS
cord-015021-pol2qm74	5521	20	with	with	IN
cord-015021-pol2qm74	5521	21	MOF	MOF	NNP
cord-015021-pol2qm74	5521	22	and	and	CC
cord-015021-pol2qm74	5521	23	used	use	VBD
cord-015021-pol2qm74	5521	24	the	the	DT
cord-015021-pol2qm74	5521	25	term	term	NN
cord-015021-pol2qm74	5521	26	multiplesystems	multiplesystem	NNS
cord-015021-pol2qm74	5521	27	organ	organ	NN
cord-015021-pol2qm74	5521	28	feilmo	feilmo	NNP
cord-015021-pol2qm74	5521	29	(	(	-LRB-
cord-015021-pol2qm74	5521	30	MSOF	MSOF	NNP
cord-015021-pol2qm74	5521	31	)	)	-RRB-
cord-015021-pol2qm74	5521	32	.	.	.
cord-015021-pol2qm74	5522	1	Other	other	JJ
cord-015021-pol2qm74	5522	2	early	early	JJ
cord-015021-pol2qm74	5522	3	conltibutots	conltibutot	NNS
cord-015021-pol2qm74	5522	4	to	to	IN
cord-015021-pol2qm74	5522	5	our	-PRON-	PRP$
cord-015021-pol2qm74	5522	6	knowledge	knowledge	NN
cord-015021-pol2qm74	5522	7	of	of	IN
cord-015021-pol2qm74	5522	8	MOF	MOF	NNP
cord-015021-pol2qm74	5522	9	include	include	VBP
cord-015021-pol2qm74	5522	10	Faist	Faist	NNP
cord-015021-pol2qm74	5522	11	,	,	,
cord-015021-pol2qm74	5522	12	Trunkey	Trunkey	NNP
cord-015021-pol2qm74	5522	13	and	and	CC
cord-015021-pol2qm74	5522	14	Miller	Miller	NNP
cord-015021-pol2qm74	5522	15	,	,	,
cord-015021-pol2qm74	5522	16	Marshall	Marshall	NNP
cord-015021-pol2qm74	5522	17	and	and	CC
cord-015021-pol2qm74	5522	18	Dimic	Dimic	NNP
cord-015021-pol2qm74	5522	19	&	&	CC
cord-015021-pol2qm74	5522	20	,	,	,
cord-015021-pol2qm74	5522	21	Cassone	Cassone	NNP
cord-015021-pol2qm74	5522	22	,	,	,
cord-015021-pol2qm74	5522	23	Catlleo	Catlleo	NNP
cord-015021-pol2qm74	5522	24	,	,	,
cord-015021-pol2qm74	5522	25	Meakins	Meakins	NNP
cord-015021-pol2qm74	5522	26	and	and	CC
cord-015021-pol2qm74	5522	27	Marshall	Marshall	NNP
cord-015021-pol2qm74	5522	28	,	,	,
cord-015021-pol2qm74	5522	29	(	(	-LRB-
cord-015021-pol2qm74	5522	30	}	}	-RRB-
cord-015021-pol2qm74	5522	31	otis	otis	NNP
cord-015021-pol2qm74	5522	32	et	et	NNP
cord-015021-pol2qm74	5522	33	at	at	IN
cord-015021-pol2qm74	5522	34	.	.	.
cord-015021-pol2qm74	5523	1	,	,	,
cord-015021-pol2qm74	5523	2	Mater	mater	NN
cord-015021-pol2qm74	5523	3	and	and	CC
cord-015021-pol2qm74	5523	4	many	many	JJ
cord-015021-pol2qm74	5523	5	others	other	NNS
cord-015021-pol2qm74	5523	6	.	.	.
cord-015021-pol2qm74	5524	1	MOF	MOF	NNP
cord-015021-pol2qm74	5524	2	or	or	CC
cord-015021-pol2qm74	5524	3	MSOF	MSOF	NNP
cord-015021-pol2qm74	5524	4	were	be	VBD
cord-015021-pol2qm74	5524	5	used	use	VBN
cord-015021-pol2qm74	5524	6	eommoifly	eommoifly	NN
cord-015021-pol2qm74	5524	7	.	.	.
cord-015021-pol2qm74	5525	1	Cerra	Cerra	NNP
cord-015021-pol2qm74	5525	2	coined	coin	VBD
cord-015021-pol2qm74	5525	3	the	the	DT
cord-015021-pol2qm74	5525	4	terms	term	NNS
cord-015021-pol2qm74	5525	5	"	"	``
cord-015021-pol2qm74	5525	6	post	post	JJ
cord-015021-pol2qm74	5525	7	-	-	JJ
cord-015021-pol2qm74	5525	8	trsumatic	trsumatic	JJ
cord-015021-pol2qm74	5525	9	septic	septic	NN
cord-015021-pol2qm74	5525	10	sFndromc	sFndromc	NNP
cord-015021-pol2qm74	5525	11	"	"	''
cord-015021-pol2qm74	5525	12	and	and	CC
cord-015021-pol2qm74	5525	13	"	"	``
cord-015021-pol2qm74	5525	14	hyper	hyper	JJ
cord-015021-pol2qm74	5525	15	metabolism	metabolism	NN
cord-015021-pol2qm74	5525	16	otgau	otgau	NN
cord-015021-pol2qm74	5525	17	failure	failure	NN
cord-015021-pol2qm74	5525	18	complex	complex	JJ
cord-015021-pol2qm74	5525	19	"	"	''
cord-015021-pol2qm74	5525	20	,	,	,
cord-015021-pol2qm74	5525	21	and	and	CC
cord-015021-pol2qm74	5525	22	Border	Border	NNP
cord-015021-pol2qm74	5525	23	et	et	NNP
cord-015021-pol2qm74	5525	24	al	al	NNP
cord-015021-pol2qm74	5525	25	,	,	,
cord-015021-pol2qm74	5525	26	used	use	VBD
cord-015021-pol2qm74	5525	27	lhe	lhe	NNP
cord-015021-pol2qm74	5525	28	ex3~ression	ex3~ression	NN
cord-015021-pol2qm74	5525	29	"	"	``
cord-015021-pol2qm74	5525	30	gut	gut	VB
cord-015021-pol2qm74	5525	31	origin	origin	NNP
cord-015021-pol2qm74	5525	32	seplic	seplic	NNP
cord-015021-pol2qm74	5525	33	states	state	NNS
cord-015021-pol2qm74	5525	34	"	"	''
cord-015021-pol2qm74	5525	35	to	to	TO
cord-015021-pol2qm74	5525	36	illdioate	illdioate	VB
cord-015021-pol2qm74	5525	37	important	important	JJ
cord-015021-pol2qm74	5525	38	eurrem	eurrem	NNP
cord-015021-pol2qm74	5525	39	aspects	aspect	NNS
cord-015021-pol2qm74	5525	40	of	of	IN
cord-015021-pol2qm74	5525	41	abe	abe	NNP
cord-015021-pol2qm74	5525	42	gt	gt	NNP
cord-015021-pol2qm74	5525	43	.	.	.
cord-015021-pol2qm74	5526	1	'	'	``
cord-015021-pol2qm74	5526	2	nerlc	nerlc	NNP
cord-015021-pol2qm74	5526	3	problem	problem	NN
cord-015021-pol2qm74	5526	4	of	of	IN
cord-015021-pol2qm74	5526	5	organ	organ	NN
cord-015021-pol2qm74	5526	6	failure	failure	NN
cord-015021-pol2qm74	5526	7	and	and	CC
cord-015021-pol2qm74	5526	8	death	death	NN
cord-015021-pol2qm74	5527	1	,	,	,
cord-015021-pol2qm74	5527	2	Other	other	JJ
cord-015021-pol2qm74	5527	3	terms	term	NNS
cord-015021-pol2qm74	5527	4	include	include	VBP
cord-015021-pol2qm74	5527	5	acute	acute	JJ
cord-015021-pol2qm74	5527	6	organ	organ	NN
cord-015021-pol2qm74	5527	7	-	-	HYPH
cord-015021-pol2qm74	5527	8	system	system	NN
cord-015021-pol2qm74	5527	9	failure	failure	NN
cord-015021-pol2qm74	5527	10	,	,	,
cord-015021-pol2qm74	5527	11	multiple	multiple	JJ
cord-015021-pol2qm74	5527	12	organ	organ	NN
cord-015021-pol2qm74	5527	13	injury	injury	NN
cord-015021-pol2qm74	5527	14	syndrome	syndrome	NN
cord-015021-pol2qm74	5527	15	,	,	,
cord-015021-pol2qm74	5527	16	post	post	JJ
cord-015021-pol2qm74	5527	17	-	-	JJ
cord-015021-pol2qm74	5527	18	traumatic	traumatic	JJ
cord-015021-pol2qm74	5527	19	multi	multi	JJ
cord-015021-pol2qm74	5527	20	-	-	JJ
cord-015021-pol2qm74	5527	21	system	system	JJ
cord-015021-pol2qm74	5527	22	organ	organ	NN
cord-015021-pol2qm74	5527	23	failure	failure	NN
cord-015021-pol2qm74	5527	24	nod	nod	CC
cord-015021-pol2qm74	5527	25	post-~aumatic	post-~aumatic	JJ
cord-015021-pol2qm74	5527	26	organ	organ	NN
cord-015021-pol2qm74	5527	27	system	system	NN
cord-015021-pol2qm74	5527	28	infection	infection	NN
cord-015021-pol2qm74	5527	29	s	s	NNP
cord-015021-pol2qm74	5527	30	~	~	NFP
cord-015021-pol2qm74	5527	31	dmmc	dmmc	NNP
cord-015021-pol2qm74	5527	32	(	(	-LRB-
cord-015021-pol2qm74	5527	33	FI	FI	NNP
cord-015021-pol2qm74	5527	34	~	~	NFP
cord-015021-pol2qm74	5527	35	SIS	SIS	NNP
cord-015021-pol2qm74	5527	36	)	)	-RRB-
cord-015021-pol2qm74	5527	37	,	,	,
cord-015021-pol2qm74	5527	38	I	-PRON-	PRP
cord-015021-pol2qm74	5527	39	bdieve	bdieve	VBP
cord-015021-pol2qm74	5527	40	the	the	DT
cord-015021-pol2qm74	5527	41	latin	latin	NNP
cord-015021-pol2qm74	5527	42	"	"	``
cord-015021-pol2qm74	5527	43	maltiple	maltiple	JJ
cord-015021-pol2qm74	5527	44	organ	organ	NN
cord-015021-pol2qm74	5527	45	failure	failure	NN
cord-015021-pol2qm74	5527	46	"	"	''
cord-015021-pol2qm74	5527	47	is	be	VBZ
cord-015021-pol2qm74	5527	48	clean	clean	JJ
cord-015021-pol2qm74	5527	49	,	,	,
cord-015021-pol2qm74	5527	50	neat	neat	JJ
cord-015021-pol2qm74	5527	51	and	and	CC
cord-015021-pol2qm74	5527	52	says	say	VBZ
cord-015021-pol2qm74	5527	53	it	-PRON-	PRP
cord-015021-pol2qm74	5527	54	all	all	DT
cord-015021-pol2qm74	5527	55	,	,	,
cord-015021-pol2qm74	5527	56	Now	now	RB
cord-015021-pol2qm74	5527	57	there	there	EX
cord-015021-pol2qm74	5527	58	is	be	VBZ
cord-015021-pol2qm74	5527	59	a	a	DT
cord-015021-pol2qm74	5527	60	proposal	proposal	NN
cord-015021-pol2qm74	5527	61	for	for	IN
cord-015021-pol2qm74	5527	62	a	a	DT
cord-015021-pol2qm74	5527	63	new	new	JJ
cord-015021-pol2qm74	5527	64	set	set	NN
cord-015021-pol2qm74	5527	65	of	of	IN
cord-015021-pol2qm74	5527	66	torminolugios	torminolugios	NNP
cord-015021-pol2qm74	5527	67	-MODS	-MODS	NNP
cord-015021-pol2qm74	5527	68	and	and	CC
cord-015021-pol2qm74	5527	69	SIRS	SIRS	NNP
cord-015021-pol2qm74	5527	70	.	.	.
cord-015021-pol2qm74	5528	1	Will	Will	MD
cord-015021-pol2qm74	5528	2	they	-PRON-	PRP
cord-015021-pol2qm74	5528	3	be	be	VB
cord-015021-pol2qm74	5528	4	helpful	helpful	JJ
cord-015021-pol2qm74	5528	5	in	in	IN
cord-015021-pol2qm74	5528	6	the	the	DT
cord-015021-pol2qm74	5528	7	study	study	NN
cord-015021-pol2qm74	5528	8	and	and	CC
cord-015021-pol2qm74	5528	9	esro	esro	NNS
cord-015021-pol2qm74	5528	10	of	of	IN
cord-015021-pol2qm74	5528	11	patients	patient	NNS
cord-015021-pol2qm74	5528	12	?	?	.
cord-015021-pol2qm74	5529	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	5529	2	speakers	speaker	NNS
cord-015021-pol2qm74	5529	3	in	in	IN
cord-015021-pol2qm74	5529	4	this	this	DT
cord-015021-pol2qm74	5529	5	session	session	NN
cord-015021-pol2qm74	5529	6	will	will	MD
cord-015021-pol2qm74	5529	7	review	review	VB
cord-015021-pol2qm74	5529	8	thcsa	thcsa	NNP
cord-015021-pol2qm74	5529	9	proposals	proposal	NNS
cord-015021-pol2qm74	5529	10	and	and	CC
cord-015021-pol2qm74	5529	11	the	the	DT
cord-015021-pol2qm74	5529	12	evidence	evidence	NN
cord-015021-pol2qm74	5529	13	as	as	IN
cord-015021-pol2qm74	5529	14	we	-PRON-	PRP
cord-015021-pol2qm74	5529	15	strlVO	strlVO	NNP
cord-015021-pol2qm74	5529	16	for	for	IN
cord-015021-pol2qm74	5529	17	eoasensns	eoasensns	NN
cord-015021-pol2qm74	5529	18	.	.	.
cord-015021-pol2qm74	5530	1	It	-PRON-	PRP
cord-015021-pol2qm74	5530	2	has	have	VBZ
cord-015021-pol2qm74	5530	3	been	be	VBN
cord-015021-pol2qm74	5530	4	well	well	RB
cord-015021-pol2qm74	5530	5	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	5530	6	that	that	IN
cord-015021-pol2qm74	5530	7	the	the	DT
cord-015021-pol2qm74	5530	8	administration	administration	NN
cord-015021-pol2qm74	5530	9	of	of	IN
cord-015021-pol2qm74	5530	10	pro	pro	JJ
cord-015021-pol2qm74	5530	11	-	-	JJ
cord-015021-pol2qm74	5530	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5530	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	5530	14	,	,	,
cord-015021-pol2qm74	5530	15	and	and	CC
cord-015021-pol2qm74	5530	16	especially	especially	RB
cord-015021-pol2qm74	5530	17	tumor	tumor	NN
cord-015021-pol2qm74	5530	18	necrosis	necrosis	NN
cord-015021-pol2qm74	5530	19	factor	factor	NN
cord-015021-pol2qm74	5530	20	(	(	-LRB-
cord-015021-pol2qm74	5530	21	TNF	TNF	NNP
cord-015021-pol2qm74	5530	22	)	)	-RRB-
cord-015021-pol2qm74	5530	23	can	can	MD
cord-015021-pol2qm74	5530	24	result	result	VB
cord-015021-pol2qm74	5530	25	in	in	IN
cord-015021-pol2qm74	5530	26	a	a	DT
cord-015021-pol2qm74	5530	27	picture	picture	NN
cord-015021-pol2qm74	5530	28	similar	similar	JJ
cord-015021-pol2qm74	5530	29	to	to	IN
cord-015021-pol2qm74	5530	30	septic	septic	JJ
cord-015021-pol2qm74	5530	31	shock	shock	NN
cord-015021-pol2qm74	5530	32	with	with	IN
cord-015021-pol2qm74	5530	33	secondary	secondary	JJ
cord-015021-pol2qm74	5530	34	multiple	multiple	JJ
cord-015021-pol2qm74	5530	35	organ	organ	NN
cord-015021-pol2qm74	5530	36	failure	failure	NN
cord-015021-pol2qm74	5530	37	.	.	.
cord-015021-pol2qm74	5531	1	It	-PRON-	PRP
cord-015021-pol2qm74	5531	2	is	be	VBZ
cord-015021-pol2qm74	5531	3	also	also	RB
cord-015021-pol2qm74	5531	4	clear	clear	JJ
cord-015021-pol2qm74	5531	5	that	that	IN
cord-015021-pol2qm74	5531	6	tissue	tissue	NN
cord-015021-pol2qm74	5531	7	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5531	8	can	can	MD
cord-015021-pol2qm74	5531	9	lead	lead	VB
cord-015021-pol2qm74	5531	10	to	to	IN
cord-015021-pol2qm74	5531	11	organ	organ	NN
cord-015021-pol2qm74	5531	12	damage	damage	NN
cord-015021-pol2qm74	5531	13	.	.	.
cord-015021-pol2qm74	5532	1	We	-PRON-	PRP
cord-015021-pol2qm74	5532	2	believe	believe	VBP
cord-015021-pol2qm74	5532	3	that	that	IN
cord-015021-pol2qm74	5532	4	it	-PRON-	PRP
cord-015021-pol2qm74	5532	5	is	be	VBZ
cord-015021-pol2qm74	5532	6	the	the	DT
cord-015021-pol2qm74	5532	7	interaction	interaction	NN
cord-015021-pol2qm74	5532	8	between	between	IN
cord-015021-pol2qm74	5532	9	the	the	DT
cord-015021-pol2qm74	5532	10	two	two	CD
cord-015021-pol2qm74	5532	11	phenomenons	phenomenon	NNS
cord-015021-pol2qm74	5532	12	that	that	WDT
cord-015021-pol2qm74	5532	13	can	can	MD
cord-015021-pol2qm74	5532	14	lead	lead	VB
cord-015021-pol2qm74	5532	15	to	to	IN
cord-015021-pol2qm74	5532	16	MOF	MOF	NNP
cord-015021-pol2qm74	5532	17	.	.	.
cord-015021-pol2qm74	5533	1	On	on	IN
cord-015021-pol2qm74	5533	2	the	the	DT
cord-015021-pol2qm74	5533	3	one	one	CD
cord-015021-pol2qm74	5533	4	hand	hand	NN
cord-015021-pol2qm74	5533	5	,	,	,
cord-015021-pol2qm74	5533	6	the	the	DT
cord-015021-pol2qm74	5533	7	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5533	8	response	response	NN
cord-015021-pol2qm74	5533	9	is	be	VBZ
cord-015021-pol2qm74	5533	10	amplified	amplify	VBN
cord-015021-pol2qm74	5533	11	in	in	IN
cord-015021-pol2qm74	5533	12	the	the	DT
cord-015021-pol2qm74	5533	13	presence	presence	NN
cord-015021-pol2qm74	5533	14	of	of	IN
cord-015021-pol2qm74	5533	15	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5533	16	.	.	.
cord-015021-pol2qm74	5534	1	On	on	IN
cord-015021-pol2qm74	5534	2	the	the	DT
cord-015021-pol2qm74	5534	3	other	other	JJ
cord-015021-pol2qm74	5534	4	hand	hand	NN
cord-015021-pol2qm74	5534	5	,	,	,
cord-015021-pol2qm74	5534	6	the	the	DT
cord-015021-pol2qm74	5534	7	release	release	NN
cord-015021-pol2qm74	5534	8	of	of	IN
cord-015021-pol2qm74	5534	9	the	the	DT
cord-015021-pol2qm74	5534	10	mediators	mediator	NNS
cord-015021-pol2qm74	5534	11	of	of	IN
cord-015021-pol2qm74	5534	12	sepsis	sepsis	NN
cord-015021-pol2qm74	5534	13	can	can	MD
cord-015021-pol2qm74	5534	14	increase	increase	VB
cord-015021-pol2qm74	5534	15	tbe	tbe	JJ
cord-015021-pol2qm74	5534	16	oxygen	oxygen	NN
cord-015021-pol2qm74	5534	17	demand	demand	NN
cord-015021-pol2qm74	5534	18	ef	ef	NNP
cord-015021-pol2qm74	5534	19	the	the	DT
cord-015021-pol2qm74	5534	20	tissues	tissue	NNS
cord-015021-pol2qm74	5534	21	,	,	,
cord-015021-pol2qm74	5534	22	alter	alter	VB
cord-015021-pol2qm74	5534	23	their	-PRON-	PRP$
cord-015021-pol2qm74	5534	24	oxygen	oxygen	NN
cord-015021-pol2qm74	5534	25	extraction	extraction	NN
cord-015021-pol2qm74	5534	26	and	and	CC
cord-015021-pol2qm74	5534	27	decrease	decrease	VB
cord-015021-pol2qm74	5534	28	myocardial	myocardial	JJ
cord-015021-pol2qm74	5534	29	contractility	contractility	NN
cord-015021-pol2qm74	5534	30	,	,	,
cord-015021-pol2qm74	5534	31	and	and	CC
cord-015021-pol2qm74	5534	32	the	the	DT
cord-015021-pol2qm74	5534	33	combination	combination	NN
cord-015021-pol2qm74	5534	34	of	of	IN
cord-015021-pol2qm74	5534	35	these	these	DT
cord-015021-pol2qm74	5534	36	elements	element	NNS
cord-015021-pol2qm74	5534	37	accounts	account	VBZ
cord-015021-pol2qm74	5534	38	for	for	IN
cord-015021-pol2qm74	5534	39	the	the	DT
cord-015021-pol2qm74	5534	40	development	development	NN
cord-015021-pol2qm74	5534	41	of	of	IN
cord-015021-pol2qm74	5534	42	septic	septic	JJ
cord-015021-pol2qm74	5534	43	shock	shock	NN
cord-015021-pol2qm74	5534	44	.	.	.
cord-015021-pol2qm74	5535	1	This	this	DT
cord-015021-pol2qm74	5535	2	hypothesis	hypothesis	NN
cord-015021-pol2qm74	5535	3	is	be	VBZ
cord-015021-pol2qm74	5535	4	supported	support	VBN
cord-015021-pol2qm74	5535	5	by	by	IN
cord-015021-pol2qm74	5535	6	two	two	CD
cord-015021-pol2qm74	5535	7	lines	line	NNS
cord-015021-pol2qm74	5535	8	of	of	IN
cord-015021-pol2qm74	5535	9	evidence	evidence	NN
cord-015021-pol2qm74	5535	10	.	.	.
cord-015021-pol2qm74	5536	1	First	first	RB
cord-015021-pol2qm74	5536	2	,	,	,
cord-015021-pol2qm74	5536	3	MOF	MOF	NNP
cord-015021-pol2qm74	5536	4	is	be	VBZ
cord-015021-pol2qm74	5536	5	usually	usually	RB
cord-015021-pol2qm74	5536	6	preceded	precede	VBN
cord-015021-pol2qm74	5536	7	by	by	IN
cord-015021-pol2qm74	5536	8	an	an	DT
cord-015021-pol2qm74	5536	9	episode	episode	NN
cord-015021-pol2qm74	5536	10	of	of	IN
cord-015021-pol2qm74	5536	11	acute	acute	JJ
cord-015021-pol2qm74	5536	12	circulatory	circulatory	JJ
cord-015021-pol2qm74	5536	13	failure	failure	NN
cord-015021-pol2qm74	5536	14	(	(	-LRB-
cord-015021-pol2qm74	5536	15	even	even	RB
cord-015021-pol2qm74	5536	16	though	though	IN
cord-015021-pol2qm74	5536	17	frank	frank	JJ
cord-015021-pol2qm74	5536	18	circulatory	circulatory	JJ
cord-015021-pol2qm74	5536	19	shock	shock	NN
cord-015021-pol2qm74	5536	20	may	may	MD
cord-015021-pol2qm74	5536	21	not	not	RB
cord-015021-pol2qm74	5536	22	be	be	VB
cord-015021-pol2qm74	5536	23	evident	evident	JJ
cord-015021-pol2qm74	5536	24	)	)	-RRB-
cord-015021-pol2qm74	5536	25	.	.	.
cord-015021-pol2qm74	5537	1	Second	second	RB
cord-015021-pol2qm74	5537	2	,	,	,
cord-015021-pol2qm74	5537	3	recent	recent	JJ
cord-015021-pol2qm74	5537	4	experimental	experimental	JJ
cord-015021-pol2qm74	5537	5	and	and	CC
cord-015021-pol2qm74	5537	6	clinical	clinical	JJ
cord-015021-pol2qm74	5537	7	studies	study	NNS
cord-015021-pol2qm74	5537	8	indicated	indicate	VBD
cord-015021-pol2qm74	5537	9	that	that	IN
cord-015021-pol2qm74	5537	10	immunotherapy	immunotherapy	NN
cord-015021-pol2qm74	5537	11	(	(	-LRB-
cord-015021-pol2qm74	5537	12	especially	especially	RB
cord-015021-pol2qm74	5537	13	antibodies	antibody	NNS
cord-015021-pol2qm74	5537	14	to	to	IN
cord-015021-pol2qm74	5537	15	TNF	TNF	NNP
cord-015021-pol2qm74	5537	16	)	)	-RRB-
cord-015021-pol2qm74	5537	17	is	be	VBZ
cord-015021-pol2qm74	5537	18	particularly	particularly	RB
cord-015021-pol2qm74	5537	19	effective	effective	JJ
cord-015021-pol2qm74	5537	20	in	in	IN
cord-015021-pol2qm74	5537	21	the	the	DT
cord-015021-pol2qm74	5537	22	most	most	RBS
cord-015021-pol2qm74	5537	23	severe	severe	JJ
cord-015021-pol2qm74	5537	24	forms	form	NNS
cord-015021-pol2qm74	5537	25	of	of	IN
cord-015021-pol2qm74	5537	26	sepsis	sepsis	NN
cord-015021-pol2qm74	5537	27	,	,	,
cord-015021-pol2qm74	5537	28	associated	associate	VBN
cord-015021-pol2qm74	5537	29	with	with	IN
cord-015021-pol2qm74	5537	30	circulatory	circulatory	JJ
cord-015021-pol2qm74	5537	31	shock	shock	NN
cord-015021-pol2qm74	5537	32	.	.	.
cord-015021-pol2qm74	5538	1	Hence	hence	RB
cord-015021-pol2qm74	5538	2	,	,	,
cord-015021-pol2qm74	5538	3	an	an	DT
cord-015021-pol2qm74	5538	4	effective	effective	JJ
cord-015021-pol2qm74	5538	5	way	way	NN
cord-015021-pol2qm74	5538	6	to	to	TO
cord-015021-pol2qm74	5538	7	prevent	prevent	VB
cord-015021-pol2qm74	5538	8	MOF	MOF	NNP
cord-015021-pol2qm74	5538	9	may	may	MD
cord-015021-pol2qm74	5538	10	be	be	VB
cord-015021-pol2qm74	5538	11	a	a	DT
cord-015021-pol2qm74	5538	12	combination	combination	NN
cord-015021-pol2qm74	5538	13	of	of	IN
cord-015021-pol2qm74	5538	14	aggressive	aggressive	JJ
cord-015021-pol2qm74	5538	15	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	5538	16	management	management	NN
cord-015021-pol2qm74	5538	17	and	and	CC
cord-015021-pol2qm74	5538	18	immunotherapy	immunotherapy	NN
cord-015021-pol2qm74	5538	19	.	.	.
cord-015021-pol2qm74	5539	1	Development	development	NN
cord-015021-pol2qm74	5539	2	of	of	IN
cord-015021-pol2qm74	5539	3	the	the	DT
cord-015021-pol2qm74	5539	4	multiple	multiple	JJ
cord-015021-pol2qm74	5539	5	organ	organ	NN
cord-015021-pol2qm74	5539	6	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5539	7	syndrome	syndrome	NN
cord-015021-pol2qm74	5539	8	(	(	-LRB-
cord-015021-pol2qm74	5539	9	MODS	MODS	NNP
cord-015021-pol2qm74	5539	10	)	)	-RRB-
cord-015021-pol2qm74	5539	11	in	in	IN
cord-015021-pol2qm74	5539	12	the	the	DT
cord-015021-pol2qm74	5539	13	critically	critically	RB
cord-015021-pol2qm74	5539	14	ill	ill	JJ
cord-015021-pol2qm74	5539	15	follows	follow	VBZ
cord-015021-pol2qm74	5539	16	an	an	DT
cord-015021-pol2qm74	5539	17	heterogeneous	heterogeneous	JJ
cord-015021-pol2qm74	5539	18	group	group	NN
cord-015021-pol2qm74	5539	19	of	of	IN
cord-015021-pol2qm74	5539	20	stimuli	stimulus	NNS
cord-015021-pol2qm74	5539	21	including	include	VBG
cord-015021-pol2qm74	5539	22	infection	infection	NN
cord-015021-pol2qm74	5539	23	,	,	,
cord-015021-pol2qm74	5539	24	sterile	sterile	JJ
cord-015021-pol2qm74	5539	25	inflammmion	inflammmion	NN
cord-015021-pol2qm74	5539	26	,	,	,
cord-015021-pol2qm74	5539	27	extensive	extensive	JJ
cord-015021-pol2qm74	5539	28	tissue	tissue	NN
cord-015021-pol2qm74	5539	29	injury	injury	NN
cord-015021-pol2qm74	5539	30	,	,	,
cord-015021-pol2qm74	5539	31	ischemia	ischemia	NN
cord-015021-pol2qm74	5539	32	,	,	,
cord-015021-pol2qm74	5539	33	intoxication	intoxication	NN
cord-015021-pol2qm74	5539	34	with	with	IN
cord-015021-pol2qm74	5539	35	a	a	DT
cord-015021-pol2qm74	5539	36	variety	variety	NN
cord-015021-pol2qm74	5539	37	of	of	IN
cord-015021-pol2qm74	5539	38	substances	substance	NNS
cord-015021-pol2qm74	5539	39	,	,	,
cord-015021-pol2qm74	5539	40	and	and	CC
cord-015021-pol2qm74	5539	41	immune	immune	JJ
cord-015021-pol2qm74	5539	42	system	system	NN
cord-015021-pol2qm74	5539	43	activation	activation	NN
cord-015021-pol2qm74	5539	44	.	.	.
cord-015021-pol2qm74	5540	1	Whether	whether	IN
cord-015021-pol2qm74	5540	2	the	the	DT
cord-015021-pol2qm74	5540	3	resulting	result	VBG
cord-015021-pol2qm74	5540	4	physiologic	physiologic	JJ
cord-015021-pol2qm74	5540	5	abnormalities	abnormality	NNS
cord-015021-pol2qm74	5540	6	reflect	reflect	VBP
cord-015021-pol2qm74	5540	7	a	a	DT
cord-015021-pol2qm74	5540	8	common	common	JJ
cord-015021-pol2qm74	5540	9	pathologic	pathologic	JJ
cord-015021-pol2qm74	5540	10	process	process	NN
cord-015021-pol2qm74	5540	11	,	,	,
cord-015021-pol2qm74	5540	12	or	or	CC
cord-015021-pol2qm74	5540	13	are	be	VBP
cord-015021-pol2qm74	5540	14	simply	simply	RB
cord-015021-pol2qm74	5540	15	a	a	DT
cord-015021-pol2qm74	5540	16	non	non	JJ
cord-015021-pol2qm74	5540	17	-	-	JJ
cord-015021-pol2qm74	5540	18	specific	specific	JJ
cord-015021-pol2qm74	5540	19	manifestation	manifestation	NN
cord-015021-pol2qm74	5540	20	of	of	IN
cord-015021-pol2qm74	5540	21	tissue	tissue	NN
cord-015021-pol2qm74	5540	22	injury	injury	NN
cord-015021-pol2qm74	5540	23	is	be	VBZ
cord-015021-pol2qm74	5540	24	unknown	unknown	JJ
cord-015021-pol2qm74	5540	25	.	.	.
cord-015021-pol2qm74	5541	1	Moreover	moreover	RB
cord-015021-pol2qm74	5541	2	,	,	,
cord-015021-pol2qm74	5541	3	the	the	DT
cord-015021-pol2qm74	5541	4	lack	lack	NN
cord-015021-pol2qm74	5541	5	of	of	IN
cord-015021-pol2qm74	5541	6	clearly	clearly	RB
cord-015021-pol2qm74	5541	7	-	-	HYPH
cord-015021-pol2qm74	5541	8	defined	define	VBN
cord-015021-pol2qm74	5541	9	functional	functional	JJ
cord-015021-pol2qm74	5541	10	criteria	criterion	NNS
cord-015021-pol2qm74	5541	11	for	for	IN
cord-015021-pol2qm74	5541	12	the	the	DT
cord-015021-pol2qm74	5541	13	characterization	characterization	NN
cord-015021-pol2qm74	5541	14	of	of	IN
cord-015021-pol2qm74	5541	15	the	the	DT
cord-015021-pol2qm74	5541	16	syndrome	syndrome	NN
cord-015021-pol2qm74	5541	17	on	on	IN
cord-015021-pol2qm74	5541	18	the	the	DT
cord-015021-pol2qm74	5541	19	one	one	CD
cord-015021-pol2qm74	5541	20	hand	hand	NN
cord-015021-pol2qm74	5541	21	,	,	,
cord-015021-pol2qm74	5541	22	and	and	CC
cord-015021-pol2qm74	5541	23	of	of	IN
cord-015021-pol2qm74	5541	24	reliable	reliable	JJ
cord-015021-pol2qm74	5541	25	biochemical	biochemical	JJ
cord-015021-pol2qm74	5541	26	markers	marker	NNS
cord-015021-pol2qm74	5541	27	of	of	IN
cord-015021-pol2qm74	5541	28	its	-PRON-	PRP$
cord-015021-pol2qm74	5541	29	evolution	evolution	NN
cord-015021-pol2qm74	5541	30	on	on	IN
cord-015021-pol2qm74	5541	31	the	the	DT
cord-015021-pol2qm74	5541	32	other	other	JJ
cord-015021-pol2qm74	5541	33	,	,	,
cord-015021-pol2qm74	5541	34	has	have	VBZ
cord-015021-pol2qm74	5541	35	made	make	VBN
cord-015021-pol2qm74	5541	36	attempts	attempt	NNS
cord-015021-pol2qm74	5541	37	to	to	TO
cord-015021-pol2qm74	5541	38	define	define	VB
cord-015021-pol2qm74	5541	39	its	-PRON-	PRP$
cord-015021-pol2qm74	5541	40	epidemiology	epidemiology	NN
cord-015021-pol2qm74	5541	41	and	and	CC
cord-015021-pol2qm74	5541	42	natural	natural	JJ
cord-015021-pol2qm74	5541	43	history	history	NN
cord-015021-pol2qm74	5541	44	difficult	difficult	JJ
cord-015021-pol2qm74	5541	45	.	.	.
cord-015021-pol2qm74	5542	1	Using	use	VBG
cord-015021-pol2qm74	5542	2	a	a	DT
cord-015021-pol2qm74	5542	3	numeric	numeric	JJ
cord-015021-pol2qm74	5542	4	scoring	scoring	NN
cord-015021-pol2qm74	5542	5	system	system	NN
cord-015021-pol2qm74	5542	6	to	to	TO
cord-015021-pol2qm74	5542	7	quanfimte	quanfimte	VB
cord-015021-pol2qm74	5542	8	the	the	DT
cord-015021-pol2qm74	5542	9	clinical	clinical	JJ
cord-015021-pol2qm74	5542	10	severity	severity	NN
cord-015021-pol2qm74	5542	11	of	of	IN
cord-015021-pol2qm74	5542	12	MODS	mods	NN
cord-015021-pol2qm74	5542	13	,	,	,
cord-015021-pol2qm74	5542	14	we	-PRON-	PRP
cord-015021-pol2qm74	5542	15	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	5542	16	that	that	IN
cord-015021-pol2qm74	5542	17	,	,	,
cord-015021-pol2qm74	5542	18	although	although	IN
cord-015021-pol2qm74	5542	19	MODS	MODS	NNP
cord-015021-pol2qm74	5542	20	is	be	VBZ
cord-015021-pol2qm74	5542	21	more	more	RBR
cord-015021-pol2qm74	5542	22	common	common	JJ
cord-015021-pol2qm74	5542	23	in	in	IN
cord-015021-pol2qm74	5542	24	patients	patient	NNS
cord-015021-pol2qm74	5542	25	who	who	WP
cord-015021-pol2qm74	5542	26	have	have	VBP
cord-015021-pol2qm74	5542	27	significant	significant	JJ
cord-015021-pol2qm74	5542	28	infection	infection	NN
cord-015021-pol2qm74	5542	29	at	at	IN
cord-015021-pol2qm74	5542	30	the	the	DT
cord-015021-pol2qm74	5542	31	time	time	NN
cord-015021-pol2qm74	5542	32	of	of	IN
cord-015021-pol2qm74	5542	33	ICU	ICU	NNP
cord-015021-pol2qm74	5542	34	admission	admission	NN
cord-015021-pol2qm74	5542	35	,	,	,
cord-015021-pol2qm74	5542	36	a	a	DT
cord-015021-pol2qm74	5542	37	much	much	RB
cord-015021-pol2qm74	5542	38	stronger	strong	JJR
cord-015021-pol2qm74	5542	39	correlation	correlation	NN
cord-015021-pol2qm74	5542	40	is	be	VBZ
cord-015021-pol2qm74	5542	41	evident	evident	JJ
cord-015021-pol2qm74	5542	42	between	between	IN
cord-015021-pol2qm74	5542	43	the	the	DT
cord-015021-pol2qm74	5542	44	severity	severity	NN
cord-015021-pol2qm74	5542	45	of	of	IN
cord-015021-pol2qm74	5542	46	MODS	mods	NN
cord-015021-pol2qm74	5542	47	and	and	CC
cord-015021-pol2qm74	5542	48	the	the	DT
cord-015021-pol2qm74	5542	49	subsequent	subsequent	JJ
cord-015021-pol2qm74	5542	50	development	development	NN
cord-015021-pol2qm74	5542	51	of	of	IN
cord-015021-pol2qm74	5542	52	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	5542	53	ICU	ICU	NNP
cord-015021-pol2qm74	5542	54	-	-	HYPH
cord-015021-pol2qm74	5542	55	acquired	acquire	VBN
cord-015021-pol2qm74	5542	56	infection	infection	NN
cord-015021-pol2qm74	5542	57	.	.	.
cord-015021-pol2qm74	5543	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	5543	2	the	the	DT
cord-015021-pol2qm74	5543	3	severity	severity	NN
cord-015021-pol2qm74	5543	4	of	of	IN
cord-015021-pol2qm74	5543	5	MODS	MODS	NNP
cord-015021-pol2qm74	5543	6	correlates	correlate	VBZ
cord-015021-pol2qm74	5543	7	strongly	strongly	RB
cord-015021-pol2qm74	5543	8	with	with	IN
cord-015021-pol2qm74	5543	9	the	the	DT
cord-015021-pol2qm74	5543	10	severity	severity	NN
cord-015021-pol2qm74	5543	11	of	of	IN
cord-015021-pol2qm74	5543	12	the	the	DT
cord-015021-pol2qm74	5543	13	clinical	clinical	JJ
cord-015021-pol2qm74	5543	14	septic	septic	JJ
cord-015021-pol2qm74	5543	15	response	response	NN
cord-015021-pol2qm74	5543	16	,	,	,
cord-015021-pol2qm74	5543	17	and	and	CC
cord-015021-pol2qm74	5543	18	with	with	IN
cord-015021-pol2qm74	5543	19	the	the	DT
cord-015021-pol2qm74	5543	20	degree	degree	NN
cord-015021-pol2qm74	5543	21	of	of	IN
cord-015021-pol2qm74	5543	22	immunologic	immunologic	JJ
cord-015021-pol2qm74	5543	23	compromise	compromise	NN
cord-015021-pol2qm74	5543	24	evident	evident	JJ
cord-015021-pol2qm74	5543	25	on	on	IN
cord-015021-pol2qm74	5543	26	delayed	delayed	JJ
cord-015021-pol2qm74	5543	27	type	type	NN
cord-015021-pol2qm74	5543	28	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	5543	29	skin	skin	NN
cord-015021-pol2qm74	5543	30	testing	testing	NN
cord-015021-pol2qm74	5543	31	.	.	.
cord-015021-pol2qm74	5544	1	To	to	TO
cord-015021-pol2qm74	5544	2	determine	determine	VB
cord-015021-pol2qm74	5544	3	the	the	DT
cord-015021-pol2qm74	5544	4	relative	relative	JJ
cord-015021-pol2qm74	5544	5	importance	importance	NN
cord-015021-pol2qm74	5544	6	of	of	IN
cord-015021-pol2qm74	5544	7	the	the	DT
cord-015021-pol2qm74	5544	8	initial	initial	JJ
cord-015021-pol2qm74	5544	9	stimulus	stimulus	NN
cord-015021-pol2qm74	5544	10	,	,	,
cord-015021-pol2qm74	5544	11	and	and	CC
cord-015021-pol2qm74	5544	12	the	the	DT
cord-015021-pol2qm74	5544	13	host	host	NN
cord-015021-pol2qm74	5544	14	response	response	NN
cord-015021-pol2qm74	5544	15	to	to	IN
cord-015021-pol2qm74	5544	16	that	that	DT
cord-015021-pol2qm74	5544	17	stimulus	stimulus	NN
cord-015021-pol2qm74	5544	18	,	,	,
cord-015021-pol2qm74	5544	19	to	to	IN
cord-015021-pol2qm74	5544	20	the	the	DT
cord-015021-pol2qm74	5544	21	subsequent	subsequent	JJ
cord-015021-pol2qm74	5544	22	emergence	emergence	NN
cord-015021-pol2qm74	5544	23	of	of	IN
cord-015021-pol2qm74	5544	24	MODS	mods	NN
cord-015021-pol2qm74	5544	25	,	,	,
cord-015021-pol2qm74	5544	26	we	-PRON-	PRP
cord-015021-pol2qm74	5544	27	undertook	undertake	VBD
cord-015021-pol2qm74	5544	28	a	a	DT
cord-015021-pol2qm74	5544	29	matched	match	VBN
cord-015021-pol2qm74	5544	30	cohort	cohort	NN
cord-015021-pol2qm74	5544	31	study	study	NN
cord-015021-pol2qm74	5544	32	of	of	IN
cord-015021-pol2qm74	5544	33	109	109	CD
cord-015021-pol2qm74	5544	34	critically	critically	RB
cord-015021-pol2qm74	5544	35	ill	ill	JJ
cord-015021-pol2qm74	5544	36	patients	patient	NNS
cord-015021-pol2qm74	5544	37	admitted	admit	VBN
cord-015021-pol2qm74	5544	38	to	to	IN
cord-015021-pol2qm74	5544	39	the	the	DT
cord-015021-pol2qm74	5544	40	ICU	ICU	NNP
cord-015021-pol2qm74	5544	41	with	with	IN
cord-015021-pol2qm74	5544	42	infection	infection	NN
cord-015021-pol2qm74	5544	43	,	,	,
cord-015021-pol2qm74	5544	44	matched	match	VBN
cord-015021-pol2qm74	5544	45	by	by	IN
cord-015021-pol2qm74	5544	46	age	age	NN
cord-015021-pol2qm74	5544	47	,	,	,
cord-015021-pol2qm74	5544	48	sex	sex	NN
cord-015021-pol2qm74	5544	49	,	,	,
cord-015021-pol2qm74	5544	50	and	and	CC
cord-015021-pol2qm74	5544	51	APACHE	APACHE	NNP
cord-015021-pol2qm74	5544	52	II	II	NNP
cord-015021-pol2qm74	5544	53	score	score	NN
cord-015021-pol2qm74	5544	54	to	to	IN
cord-015021-pol2qm74	5544	55	109	109	CD
cord-015021-pol2qm74	5544	56	uninfected	uninfected	JJ
cord-015021-pol2qm74	5544	57	controls	control	NNS
cord-015021-pol2qm74	5544	58	.	.	.
cord-015021-pol2qm74	5545	1	Organ	organ	NN
cord-015021-pol2qm74	5545	2	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5545	3	scores	score	NNS
cord-015021-pol2qm74	5545	4	were	be	VBD
cord-015021-pol2qm74	5545	5	higher	high	JJR
cord-015021-pol2qm74	5545	6	in	in	IN
cord-015021-pol2qm74	5545	7	patients	patient	NNS
cord-015021-pol2qm74	5545	8	admitted	admit	VBN
cord-015021-pol2qm74	5545	9	with	with	IN
cord-015021-pol2qm74	5545	10	infection	infection	NN
cord-015021-pol2qm74	5545	11	,	,	,
cord-015021-pol2qm74	5545	12	but	but	CC
cord-015021-pol2qm74	5545	13	were	be	VBD
cord-015021-pol2qm74	5545	14	also	also	RB
cord-015021-pol2qm74	5545	15	significantly	significantly	RB
cord-015021-pol2qm74	5545	16	associated	associate	VBN
cord-015021-pol2qm74	5545	17	with	with	IN
cord-015021-pol2qm74	5545	18	the	the	DT
cord-015021-pol2qm74	5545	19	expression	expression	NN
cord-015021-pol2qm74	5545	20	of	of	IN
cord-015021-pol2qm74	5545	21	a	a	DT
cord-015021-pol2qm74	5545	22	septic	septic	JJ
cord-015021-pol2qm74	5545	23	response	response	NN
cord-015021-pol2qm74	5545	24	at	at	IN
cord-015021-pol2qm74	5545	25	the	the	DT
cord-015021-pol2qm74	5545	26	time	time	NN
cord-015021-pol2qm74	5545	27	of	of	IN
cord-015021-pol2qm74	5545	28	ICU	ICU	NNP
cord-015021-pol2qm74	5545	29	admission	admission	NN
cord-015021-pol2qm74	5545	30	,	,	,
cord-015021-pol2qm74	5545	31	independent	independent	JJ
cord-015021-pol2qm74	5545	32	of	of	IN
cord-015021-pol2qm74	5545	33	the	the	DT
cord-015021-pol2qm74	5545	34	presence	presence	NN
cord-015021-pol2qm74	5545	35	of	of	IN
cord-015021-pol2qm74	5545	36	infection	infection	NN
cord-015021-pol2qm74	5545	37	.	.	.
cord-015021-pol2qm74	5546	1	By	by	IN
cord-015021-pol2qm74	5546	2	stepwise	stepwise	JJ
cord-015021-pol2qm74	5546	3	regression	regression	NN
cord-015021-pol2qm74	5546	4	analysis	analysis	NN
cord-015021-pol2qm74	5546	5	,	,	,
cord-015021-pol2qm74	5546	6	the	the	DT
cord-015021-pol2qm74	5546	7	magnitude	magnitude	NN
cord-015021-pol2qm74	5546	8	of	of	IN
cord-015021-pol2qm74	5546	9	the	the	DT
cord-015021-pol2qm74	5546	10	septic	septic	JJ
cord-015021-pol2qm74	5546	11	response	response	NN
cord-015021-pol2qm74	5546	12	was	be	VBD
cord-015021-pol2qm74	5546	13	the	the	DT
cord-015021-pol2qm74	5546	14	most	most	RBS
cord-015021-pol2qm74	5546	15	powerful	powerful	JJ
cord-015021-pol2qm74	5546	16	predictor	predictor	NN
cord-015021-pol2qm74	5546	17	of	of	IN
cord-015021-pol2qm74	5546	18	the	the	DT
cord-015021-pol2qm74	5546	19	severity	severity	NN
cord-015021-pol2qm74	5546	20	of	of	IN
cord-015021-pol2qm74	5546	21	MODS	mods	NN
cord-015021-pol2qm74	5546	22	in	in	IN
cord-015021-pol2qm74	5546	23	both	both	CC
cord-015021-pol2qm74	5546	24	infected	infected	JJ
cord-015021-pol2qm74	5546	25	and	and	CC
cord-015021-pol2qm74	5546	26	uninfected	uninfected	JJ
cord-015021-pol2qm74	5546	27	patients	patient	NNS
cord-015021-pol2qm74	5546	28	.	.	.
cord-015021-pol2qm74	5547	1	These	these	DT
cord-015021-pol2qm74	5547	2	data	datum	NNS
cord-015021-pol2qm74	5547	3	suggest	suggest	VBP
cord-015021-pol2qm74	5547	4	a	a	DT
cord-015021-pol2qm74	5547	5	model	model	NN
cord-015021-pol2qm74	5547	6	of	of	IN
cord-015021-pol2qm74	5547	7	MODS	mods	NN
cord-015021-pol2qm74	5547	8	in	in	IN
cord-015021-pol2qm74	5547	9	which	which	WDT
cord-015021-pol2qm74	5547	10	a	a	DT
cord-015021-pol2qm74	5547	11	stimulus	stimulus	NN
cord-015021-pol2qm74	5547	12	(	(	-LRB-
cord-015021-pol2qm74	5547	13	eg	eg	IN
cord-015021-pol2qm74	5547	14	infection	infection	NN
cord-015021-pol2qm74	5547	15	)	)	-RRB-
cord-015021-pol2qm74	5547	16	and	and	CC
cord-015021-pol2qm74	5547	17	the	the	DT
cord-015021-pol2qm74	5547	18	host	host	NN
cord-015021-pol2qm74	5547	19	response	response	NN
cord-015021-pol2qm74	5547	20	to	to	IN
cord-015021-pol2qm74	5547	21	that	that	DT
cord-015021-pol2qm74	5547	22	stimulus	stimulus	NN
cord-015021-pol2qm74	5547	23	(	(	-LRB-
cord-015021-pol2qm74	5547	24	eg	eg	IN
cord-015021-pol2qm74	5547	25	the	the	DT
cord-015021-pol2qm74	5547	26	septic	septic	JJ
cord-015021-pol2qm74	5547	27	response	response	NN
cord-015021-pol2qm74	5547	28	)	)	-RRB-
cord-015021-pol2qm74	5547	29	result	result	NN
cord-015021-pol2qm74	5547	30	in	in	IN
cord-015021-pol2qm74	5547	31	a	a	DT
cord-015021-pol2qm74	5547	32	state	state	NN
cord-015021-pol2qm74	5547	33	of	of	IN
cord-015021-pol2qm74	5547	34	altered	alter	VBN
cord-015021-pol2qm74	5547	35	systemic	systemic	JJ
cord-015021-pol2qm74	5547	36	homeostasis	homeostasis	NN
cord-015021-pol2qm74	5547	37	(	(	-LRB-
cord-015021-pol2qm74	5547	38	manifested	manifest	VBN
cord-015021-pol2qm74	5547	39	in	in	IN
cord-015021-pol2qm74	5547	40	this	this	DT
cord-015021-pol2qm74	5547	41	example	example	NN
cord-015021-pol2qm74	5547	42	by	by	IN
cord-015021-pol2qm74	5547	43	immunologic	immunologic	JJ
cord-015021-pol2qm74	5547	44	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5547	45	)	)	-RRB-
cord-015021-pol2qm74	5547	46	.	.	.
cord-015021-pol2qm74	5548	1	Moreover	moreover	RB
cord-015021-pol2qm74	5548	2	they	-PRON-	PRP
cord-015021-pol2qm74	5548	3	suggest	suggest	VBP
cord-015021-pol2qm74	5548	4	that	that	IN
cord-015021-pol2qm74	5548	5	the	the	DT
cord-015021-pol2qm74	5548	6	principle	principle	JJ
cord-015021-pol2qm74	5548	7	determinant	determinant	NN
cord-015021-pol2qm74	5548	8	of	of	IN
cord-015021-pol2qm74	5548	9	the	the	DT
cord-015021-pol2qm74	5548	10	emergence	emergence	NN
cord-015021-pol2qm74	5548	11	of	of	IN
cord-015021-pol2qm74	5548	12	MODS	MODS	NNP
cord-015021-pol2qm74	5548	13	is	be	VBZ
cord-015021-pol2qm74	5548	14	the	the	DT
cord-015021-pol2qm74	5548	15	response	response	NN
cord-015021-pol2qm74	5548	16	of	of	IN
cord-015021-pol2qm74	5548	17	the	the	DT
cord-015021-pol2qm74	5548	18	host	host	NN
cord-015021-pol2qm74	5548	19	,	,	,
cord-015021-pol2qm74	5548	20	rather	rather	RB
cord-015021-pol2qm74	5548	21	than	than	IN
cord-015021-pol2qm74	5548	22	the	the	DT
cord-015021-pol2qm74	5548	23	nature	nature	NN
cord-015021-pol2qm74	5548	24	of	of	IN
cord-015021-pol2qm74	5548	25	the	the	DT
cord-015021-pol2qm74	5548	26	stimulus	stimulus	NN
cord-015021-pol2qm74	5548	27	,	,	,
cord-015021-pol2qm74	5548	28	and	and	CC
cord-015021-pol2qm74	5548	29	are	be	VBP
cord-015021-pol2qm74	5548	30	consistent	consistent	JJ
cord-015021-pol2qm74	5548	31	with	with	IN
cord-015021-pol2qm74	5548	32	the	the	DT
cord-015021-pol2qm74	5548	33	hypothesis	hypothesis	NN
cord-015021-pol2qm74	5548	34	that	that	IN
cord-015021-pol2qm74	5548	35	a	a	DT
cord-015021-pol2qm74	5548	36	stereotypie	stereotypie	JJ
cord-015021-pol2qm74	5548	37	systemic	systemic	JJ
cord-015021-pol2qm74	5548	38	response	response	NN
cord-015021-pol2qm74	5548	39	to	to	IN
cord-015021-pol2qm74	5548	40	an	an	DT
cord-015021-pol2qm74	5548	41	heterogeneous	heterogeneous	JJ
cord-015021-pol2qm74	5548	42	group	group	NN
cord-015021-pol2qm74	5548	43	of	of	IN
cord-015021-pol2qm74	5548	44	injurious	injurious	JJ
cord-015021-pol2qm74	5548	45	stimuli	stimulus	NNS
cord-015021-pol2qm74	5548	46	underlies	underlie	VBZ
cord-015021-pol2qm74	5548	47	the	the	DT
cord-015021-pol2qm74	5548	48	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	5548	49	of	of	IN
cord-015021-pol2qm74	5548	50	MODS	mod	NNS
cord-015021-pol2qm74	5548	51	.	.	.
cord-015021-pol2qm74	5549	1	Arthur	Arthur	NNP
cord-015021-pol2qm74	5549	2	E.	E.	NNP
cord-015021-pol2qm74	5549	3	Baue	Baue	NNP
cord-015021-pol2qm74	5549	4	,	,	,
cord-015021-pol2qm74	5549	5	M.D	M.D	NNP
cord-015021-pol2qm74	5549	6	,	,	,
cord-015021-pol2qm74	5550	1	Ever	ever	RB
cord-015021-pol2qm74	5550	2	since	since	IN
cord-015021-pol2qm74	5550	3	the	the	DT
cord-015021-pol2qm74	5550	4	attorapt	attorapt	NNP
cord-015021-pol2qm74	5550	5	10	10	CD
cord-015021-pol2qm74	5550	6	build	build	NN
cord-015021-pol2qm74	5550	7	the	the	DT
cord-015021-pol2qm74	5550	8	Tower	Tower	NNP
cord-015021-pol2qm74	5550	9	ef	ef	NNP
cord-015021-pol2qm74	5550	10	Babel	Babel	NNP
cord-015021-pol2qm74	5550	11	,	,	,
cord-015021-pol2qm74	5550	12	as	as	IN
cord-015021-pol2qm74	5550	13	desclibcd	desclibcd	NN
cord-015021-pol2qm74	5550	14	in	in	IN
cord-015021-pol2qm74	5550	15	the	the	DT
cord-015021-pol2qm74	5550	16	Old	Old	NNP
cord-015021-pol2qm74	5550	17	Testament	Testament	NNP
cord-015021-pol2qm74	5550	18	of	of	IN
cord-015021-pol2qm74	5550	19	the	the	DT
cord-015021-pol2qm74	5550	20	Biblc	Biblc	NNP
cord-015021-pol2qm74	5550	21	,	,	,
cord-015021-pol2qm74	5550	22	it	-PRON-	PRP
cord-015021-pol2qm74	5550	23	has	have	VBZ
cord-015021-pol2qm74	5550	24	been	be	VBN
cord-015021-pol2qm74	5550	25	difficult	difficult	JJ
cord-015021-pol2qm74	5550	26	to	to	TO
cord-015021-pol2qm74	5550	27	got	got	VB
cord-015021-pol2qm74	5550	28	agreement	agreement	NN
cord-015021-pol2qm74	5551	1	o;x	o;x	IN
cord-015021-pol2qm74	5551	2	common	common	JJ
cord-015021-pol2qm74	5551	3	definitions	definition	NNS
cord-015021-pol2qm74	5551	4	or	or	CC
cord-015021-pol2qm74	5551	5	language	language	NN
cord-015021-pol2qm74	5552	1	,	,	,
cord-015021-pol2qm74	5552	2	Although	although	IN
cord-015021-pol2qm74	5552	3	MOF	MOF	NNP
cord-015021-pol2qm74	5552	4	has	have	VBZ
cord-015021-pol2qm74	5552	5	served	serve	VBN
cord-015021-pol2qm74	5552	6	well	well	RB
cord-015021-pol2qm74	5552	7	,	,	,
cord-015021-pol2qm74	5552	8	there	there	EX
cord-015021-pol2qm74	5552	9	will	will	MD
cord-015021-pol2qm74	5552	10	always	always	RB
cord-015021-pol2qm74	5552	11	he	-PRON-	PRP
cord-015021-pol2qm74	5552	12	now	now	RB
cord-015021-pol2qm74	5552	13	classifications	classification	NNS
cord-015021-pol2qm74	5552	14	proposed	propose	VBN
cord-015021-pol2qm74	5552	15	with	with	IN
cord-015021-pol2qm74	5552	16	good	good	JJ
cord-015021-pol2qm74	5552	17	reasons	reason	NNS
cord-015021-pol2qm74	5552	18	for	for	IN
cord-015021-pol2qm74	5552	19	them	-PRON-	PRP
cord-015021-pol2qm74	5552	20	,	,	,
cord-015021-pol2qm74	5552	21	Thus	thus	RB
cord-015021-pol2qm74	5552	22	MODS	MODS	NNP
cord-015021-pol2qm74	5552	23	and	and	CC
cord-015021-pol2qm74	5552	24	SIRS	sir	NNS
cord-015021-pol2qm74	5552	25	are	be	VBP
cord-015021-pol2qm74	5552	26	not	not	RB
cord-015021-pol2qm74	5552	27	the	the	DT
cord-015021-pol2qm74	5552	28	final	final	JJ
cord-015021-pol2qm74	5552	29	oxpressinns	oxpressinns	NN
cord-015021-pol2qm74	5552	30	in	in	IN
cord-015021-pol2qm74	5552	31	the	the	DT
cord-015021-pol2qm74	5552	32	lexico	lexico	NNP
cord-015021-pol2qm74	5552	33	~	~	NFP
cord-015021-pol2qm74	5552	34	aphic	aphic	NNP
cord-015021-pol2qm74	5552	35	sweepstakes	sweepstakes	NNP
cord-015021-pol2qm74	5552	36	.	.	.
cord-015021-pol2qm74	5553	1	Attcmpts	attcmpts	JJ
cord-015021-pol2qm74	5553	2	to	to	TO
cord-015021-pol2qm74	5553	3	develop	develop	VB
cord-015021-pol2qm74	5553	4	standard	standard	JJ
cord-015021-pol2qm74	5553	5	animal	animal	NN
cord-015021-pol2qm74	5553	6	shock	shock	NN
cord-015021-pol2qm74	5553	7	and	and	CC
cord-015021-pol2qm74	5553	8	scpsis	scpsis	NN
cord-015021-pol2qm74	5553	9	models	model	NNS
cord-015021-pol2qm74	5553	10	(	(	-LRB-
cord-015021-pol2qm74	5553	11	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	5553	12	,	,	,
cord-015021-pol2qm74	5553	13	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5553	14	,	,	,
cord-015021-pol2qm74	5553	15	foes	foe	NNS
cord-015021-pol2qm74	5553	16	[	[	-LRB-
cord-015021-pol2qm74	5553	17	pellets	pellet	NNS
cord-015021-pol2qm74	5553	18	,	,	,
cord-015021-pol2qm74	5553	19	cecal	cecal	JJ
cord-015021-pol2qm74	5553	20	ligation	ligation	NN
cord-015021-pol2qm74	5553	21	and	and	CC
cord-015021-pol2qm74	5553	22	puncture	puncture	NN
cord-015021-pol2qm74	5553	23	,	,	,
cord-015021-pol2qm74	5553	24	E.	E.	NNP
cord-015021-pol2qm74	5553	25	colt	colt	NN
cord-015021-pol2qm74	5553	26	hlf0sioI0	hlf0sioI0	NNP
cord-015021-pol2qm74	5553	27	to	to	TO
cord-015021-pol2qm74	5553	28	evaluate	evaluate	VB
cord-015021-pol2qm74	5553	29	therapy	therapy	NN
cord-015021-pol2qm74	5553	30	have	have	VBP
cord-015021-pol2qm74	5553	31	net	net	NN
cord-015021-pol2qm74	5553	32	been	be	VBN
cord-015021-pol2qm74	5553	33	suoca.ssf~.	suoca.ssf~.	NNP
cord-015021-pol2qm74	5553	34	Clinical	clinical	JJ
cord-015021-pol2qm74	5553	35	syndromes	syndrome	NNS
cord-015021-pol2qm74	5553	36	of	of	IN
cord-015021-pol2qm74	5553	37	MOF	MOF	NNP
cord-015021-pol2qm74	5553	38	,	,	,
cord-015021-pol2qm74	5553	39	sepsis	sepsis	NN
cord-015021-pol2qm74	5553	40	,	,	,
cord-015021-pol2qm74	5553	41	sepsis	sepsis	NN
cord-015021-pol2qm74	5553	42	syndrome	syndrome	NN
cord-015021-pol2qm74	5553	43	and	and	CC
cord-015021-pol2qm74	5553	44	athers	ather	NNS
cord-015021-pol2qm74	5553	45	have	have	VBP
cord-015021-pol2qm74	5553	46	not	not	RB
cord-015021-pol2qm74	5553	47	been	be	VBN
cord-015021-pol2qm74	5553	48	aeacpte.d	aeacpte.d	JJ
cord-015021-pol2qm74	5553	49	by	by	RB
cord-015021-pol2qm74	5553	50	all	all	DT
cord-015021-pol2qm74	5553	51	.	.	.
cord-015021-pol2qm74	5554	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	5554	2	problem	problem	NN
cord-015021-pol2qm74	5554	3	is	be	VBZ
cord-015021-pol2qm74	5554	4	that	that	IN
cord-015021-pol2qm74	5554	5	we	-PRON-	PRP
cord-015021-pol2qm74	5554	6	arc	arc	VBP
cord-015021-pol2qm74	5555	1	tryittg	tryittg	NNP
cord-015021-pol2qm74	5555	2	tu	tu	NNP
cord-015021-pol2qm74	5555	3	d¢ffino	d¢ffino	NNP
cord-015021-pol2qm74	5555	4	a	a	DT
cord-015021-pol2qm74	5555	5	non	non	JJ
cord-015021-pol2qm74	5555	6	-	-	JJ
cord-015021-pol2qm74	5555	7	emily	emily	NNP
cord-015021-pol2qm74	5555	8	.	.	.
cord-015021-pol2qm74	5556	1	MOF	MOF	NNP
cord-015021-pol2qm74	5556	2	or	or	CC
cord-015021-pol2qm74	5556	3	MODS	MODS	NNP
cord-015021-pol2qm74	5556	4	or	or	CC
cord-015021-pol2qm74	5556	5	SIRS	SIRS	NNP
cord-015021-pol2qm74	5556	6	is	be	VBZ
cord-015021-pol2qm74	5556	7	net	net	PDT
cord-015021-pol2qm74	5556	8	a	a	DT
cord-015021-pol2qm74	5556	9	disease	disease	NN
cord-015021-pol2qm74	5556	10	or	or	CC
cord-015021-pol2qm74	5556	11	oven	oven	NN
cord-015021-pol2qm74	5556	12	a	a	DT
cord-015021-pol2qm74	5556	13	syndrome	syndrome	NN
cord-015021-pol2qm74	5556	14	.	.	.
cord-015021-pol2qm74	5557	1	It	-PRON-	PRP
cord-015021-pol2qm74	5557	2	is	be	VBZ
cord-015021-pol2qm74	5557	3	a	a	DT
cord-015021-pol2qm74	5557	4	series	series	NN
cord-015021-pol2qm74	5557	5	of	of	IN
cord-015021-pol2qm74	5557	6	complications	complication	NNS
cord-015021-pol2qm74	5557	7	of	of	IN
cord-015021-pol2qm74	5557	8	injury	injury	NN
cord-015021-pol2qm74	5557	9	,	,	,
cord-015021-pol2qm74	5557	10	disease	disease	NN
cord-015021-pol2qm74	5557	11	and	and	CC
cord-015021-pol2qm74	5557	12	intensiva	intensiva	NN
cord-015021-pol2qm74	5557	13	care	care	NN
cord-015021-pol2qm74	5557	14	which	which	WDT
cord-015021-pol2qm74	5557	15	loads	load	VBZ
cord-015021-pol2qm74	5557	16	to	to	IN
cord-015021-pol2qm74	5557	17	death	death	NN
cord-015021-pol2qm74	5557	18	for	for	IN
cord-015021-pol2qm74	5557	19	many	many	JJ
cord-015021-pol2qm74	5557	20	patients	patient	NNS
cord-015021-pol2qm74	5557	21	in	in	IN
cord-015021-pol2qm74	5557	22	intensive	intensive	JJ
cord-015021-pol2qm74	5557	23	care	care	NN
cord-015021-pol2qm74	5557	24	units	unit	NNS
cord-015021-pol2qm74	5557	25	,	,	,
cord-015021-pol2qm74	5557	26	It	-PRON-	PRP
cord-015021-pol2qm74	5557	27	is	be	VBZ
cord-015021-pol2qm74	5557	28	not	not	RB
cord-015021-pol2qm74	5557	29	a	a	DT
cord-015021-pol2qm74	5557	30	fixed	fix	VBN
cord-015021-pol2qm74	5557	31	entity	entity	NN
cord-015021-pol2qm74	5557	32	,	,	,
cord-015021-pol2qm74	5557	33	but	but	CC
cord-015021-pol2qm74	5557	34	an	an	DT
cord-015021-pol2qm74	5557	35	ewilving	ewilve	VBG
cord-015021-pol2qm74	5557	36	picture	picture	NN
cord-015021-pol2qm74	5557	37	.	.	.
cord-015021-pol2qm74	5558	1	We	-PRON-	PRP
cord-015021-pol2qm74	5558	2	have	have	VBP
cord-015021-pol2qm74	5558	3	lumped	lump	VBN
cord-015021-pol2qm74	5558	4	(	(	-LRB-
cord-015021-pol2qm74	5558	5	ugethet	ugethet	NNP
cord-015021-pol2qm74	5558	6	for	for	IN
cord-015021-pol2qm74	5558	7	therapy	therapy	NN
cord-015021-pol2qm74	5558	8	and	and	CC
cord-015021-pol2qm74	5558	9	definition	definition	NN
cord-015021-pol2qm74	5558	10	a	a	DT
cord-015021-pol2qm74	5558	11	number	number	NN
cord-015021-pol2qm74	5558	12	of	of	IN
cord-015021-pol2qm74	5558	13	diseases	disease	NNS
cord-015021-pol2qm74	5558	14	and	and	CC
cord-015021-pol2qm74	5558	15	problems	problem	NNS
cord-015021-pol2qm74	5558	16	according	accord	VBG
cord-015021-pol2qm74	5558	17	to	to	IN
cord-015021-pol2qm74	5558	18	clinical	clinical	JJ
cord-015021-pol2qm74	5558	19	manifestatieos	manifestatieos	NN
cord-015021-pol2qm74	5558	20	rather	rather	RB
cord-015021-pol2qm74	5558	21	than	than	IN
cord-015021-pol2qm74	5558	22	the	the	DT
cord-015021-pol2qm74	5558	23	eause	eause	NN
cord-015021-pol2qm74	5558	24	of	of	IN
cord-015021-pol2qm74	5558	25	Ihe	Ihe	NNP
cord-015021-pol2qm74	5558	26	problem	problem	NN
cord-015021-pol2qm74	5558	27	,	,	,
cord-015021-pol2qm74	5558	28	The	the	DT
cord-015021-pol2qm74	5558	29	search	search	NN
cord-015021-pol2qm74	5558	30	for	for	IN
cord-015021-pol2qm74	5558	31	unified	unified	JJ
cord-015021-pol2qm74	5558	32	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5558	33	has	have	VBZ
cord-015021-pol2qm74	5558	34	not	not	RB
cord-015021-pol2qm74	5558	35	bean	bean	NN
cord-015021-pol2qm74	5558	36	successful	successful	JJ
cord-015021-pol2qm74	5558	37	.	.	.
cord-015021-pol2qm74	5559	1	Will	Will	MD
cord-015021-pol2qm74	5559	2	we	-PRON-	PRP
cord-015021-pol2qm74	5559	3	benefit	benefit	VB
cord-015021-pol2qm74	5559	4	Oleo	Oleo	NNP
cord-015021-pol2qm74	5559	5	from	from	IN
cord-015021-pol2qm74	5559	6	a	a	DT
cord-015021-pol2qm74	5559	7	more	more	RBR
cord-015021-pol2qm74	5559	8	precise	precise	JJ
cord-015021-pol2qm74	5559	9	classification	classification	NN
cord-015021-pol2qm74	5559	10	and	and	CC
cord-015021-pol2qm74	5559	11	definition	definition	NN
cord-015021-pol2qm74	5559	12	of	of	IN
cord-015021-pol2qm74	5559	13	a	a	DT
cord-015021-pol2qm74	5559	14	non	non	JJ
cord-015021-pol2qm74	5559	15	-	-	JJ
cord-015021-pol2qm74	5559	16	outjty	outjty	JJ
cord-015021-pol2qm74	5559	17	,	,	,
cord-015021-pol2qm74	5559	18	a	a	DT
cord-015021-pol2qm74	5559	19	hodgu	hodgu	NN
cord-015021-pol2qm74	5559	20	-	-	HYPH
cord-015021-pol2qm74	5559	21	podge	podge	NN
cord-015021-pol2qm74	5559	22	of	of	IN
cord-015021-pol2qm74	5559	23	human	human	JJ
cord-015021-pol2qm74	5559	24	disorders	disorder	NNS
cord-015021-pol2qm74	5559	25	which	which	WDT
cord-015021-pol2qm74	5559	26	have	have	VBP
cord-015021-pol2qm74	5559	27	charsmeristic.s	charsmeristic.s	NN
cord-015021-pol2qm74	5559	28	and	and	CC
cord-015021-pol2qm74	5559	29	manifestations	manifestation	NNS
cord-015021-pol2qm74	5559	30	of	of	IN
cord-015021-pol2qm74	5559	31	tissue	tissue	NN
cord-015021-pol2qm74	5559	32	injury	injury	NN
cord-015021-pol2qm74	5559	33	,	,	,
cord-015021-pol2qm74	5559	34	inflammation	inflammation	NN
cord-015021-pol2qm74	5559	35	and	and	CC
cord-015021-pol2qm74	5559	36	infactian	infactian	NN
cord-015021-pol2qm74	5559	37	?	?	.
cord-015021-pol2qm74	5560	1	Re.hi	re.hi	DT
cord-015021-pol2qm74	5560	2	clinical	clinical	JJ
cord-015021-pol2qm74	5560	3	trials	trial	NNS
cord-015021-pol2qm74	5560	4	of	of	IN
cord-015021-pol2qm74	5560	5	potential	potential	JJ
cord-015021-pol2qm74	5560	6	"	"	``
cord-015021-pol2qm74	5560	7	magle	magle	NNP
cord-015021-pol2qm74	5560	8	ballets	ballet	NNS
cord-015021-pol2qm74	5560	9	"	"	''
cord-015021-pol2qm74	5560	10	suggest	suggest	VBP
cord-015021-pol2qm74	5560	11	that	that	IN
cord-015021-pol2qm74	5560	12	we	-PRON-	PRP
cord-015021-pol2qm74	5560	13	should	should	MD
cord-015021-pol2qm74	5560	14	go	go	VB
cord-015021-pol2qm74	5560	15	in	in	IN
cord-015021-pol2qm74	5560	16	a	a	DT
cord-015021-pol2qm74	5560	17	different	different	JJ
cord-015021-pol2qm74	5560	18	direction	direction	NN
cord-015021-pol2qm74	5560	19	--	--	:
cord-015021-pol2qm74	5560	20	instead	instead	RB
cord-015021-pol2qm74	5560	21	of	of	IN
cord-015021-pol2qm74	5560	22	lumpors	lumpor	NNS
cord-015021-pol2qm74	5560	23	,	,	,
cord-015021-pol2qm74	5560	24	we	-PRON-	PRP
cord-015021-pol2qm74	5560	25	should	should	MD
cord-015021-pol2qm74	5560	26	be	be	VB
cord-015021-pol2qm74	5560	27	splitters	splitter	NNS
cord-015021-pol2qm74	5560	28	,	,	,
cord-015021-pol2qm74	5560	29	To	to	TO
cord-015021-pol2qm74	5560	30	seek	seek	VB
cord-015021-pol2qm74	5560	31	effective	effective	JJ
cord-015021-pol2qm74	5560	32	therapy	therapy	NN
cord-015021-pol2qm74	5560	33	,	,	,
cord-015021-pol2qm74	5560	34	we	-PRON-	PRP
cord-015021-pol2qm74	5560	35	must	must	MD
cord-015021-pol2qm74	5560	36	fucus	fucus	VB
cord-015021-pol2qm74	5560	37	on	on	IN
cord-015021-pol2qm74	5560	38	specific	specific	JJ
cord-015021-pol2qm74	5560	39	disorders	disorder	NNS
cord-015021-pol2qm74	5560	40	such	such	JJ
cord-015021-pol2qm74	5560	41	as	as	IN
cord-015021-pol2qm74	5560	42	trauma	trauma	NN
cord-015021-pol2qm74	5560	43	,	,	,
cord-015021-pol2qm74	5560	44	specific	specific	JJ
cord-015021-pol2qm74	5560	45	infections	infection	NNS
cord-015021-pol2qm74	5560	46	,	,	,
cord-015021-pol2qm74	5560	47	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5560	48	disease	disease	NN
cord-015021-pol2qm74	5560	49	and	and	CC
cord-015021-pol2qm74	5560	50	chronic	chronic	JJ
cord-015021-pol2qm74	5560	51	or	or	CC
cord-015021-pol2qm74	5560	52	acute	acute	JJ
cord-015021-pol2qm74	5560	53	organ	organ	NN
cord-015021-pol2qm74	5560	54	damage	damage	NN
cord-015021-pol2qm74	5561	1	(	(	-LRB-
cord-015021-pol2qm74	5561	2	COPD	COPD	NNP
cord-015021-pol2qm74	5561	3	-renal	-renal	JJ
cord-015021-pol2qm74	5561	4	failure	failure	NN
cord-015021-pol2qm74	5561	5	,	,	,
cord-015021-pol2qm74	5561	6	etc	etc	FW
cord-015021-pol2qm74	5561	7	.	.	.
cord-015021-pol2qm74	5561	8	)	)	-RRB-
cord-015021-pol2qm74	5562	1	,	,	,
cord-015021-pol2qm74	5562	2	I	-PRON-	PRP
cord-015021-pol2qm74	5562	3	will	will	MD
cord-015021-pol2qm74	5562	4	say	say	VB
cord-015021-pol2qm74	5562	5	more	more	JJR
cord-015021-pol2qm74	5562	6	aboet	aboet	NNP
cord-015021-pol2qm74	5563	1	this	this	DT
cord-015021-pol2qm74	5563	2	later	later	RB
cord-015021-pol2qm74	5563	3	ha	ha	UH
cord-015021-pol2qm74	5563	4	the	the	DT
cord-015021-pol2qm74	5563	5	me.ethag	me.ethag	NNP
cord-015021-pol2qm74	5563	6	.	.	.
cord-015021-pol2qm74	5564	1	Thcre	Thcre	NNP
cord-015021-pol2qm74	5564	2	is	be	VBZ
cord-015021-pol2qm74	5564	3	cue	cue	NN
cord-015021-pol2qm74	5564	4	potentially	potentially	RB
cord-015021-pol2qm74	5564	5	important	important	JJ
cord-015021-pol2qm74	5564	6	pert	pert	NN
cord-015021-pol2qm74	5564	7	of	of	IN
cord-015021-pol2qm74	5564	8	the	the	DT
cord-015021-pol2qm74	5564	9	MODS	MODS	NNP
cord-015021-pol2qm74	5564	10	proposal	proposal	NN
cord-015021-pol2qm74	5564	11	,	,	,
cord-015021-pol2qm74	5564	12	and	and	CC
cord-015021-pol2qm74	5564	13	that	that	DT
cord-015021-pol2qm74	5564	14	would	would	MD
cord-015021-pol2qm74	5564	15	be	be	VB
cord-015021-pol2qm74	5564	16	do	do	VB
cord-015021-pol2qm74	5564	17	~	~	CD
cord-015021-pol2qm74	5564	18	mcntation	mcntation	NN
cord-015021-pol2qm74	5564	19	of	of	IN
cord-015021-pol2qm74	5564	20	organ	organ	NN
cord-015021-pol2qm74	5564	21	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5564	22	before	before	IN
cord-015021-pol2qm74	5564	23	fsiiure	fsiiure	JJ
cord-015021-pol2qm74	5564	24	occurs	occur	VBZ
cord-015021-pol2qm74	5564	25	and	and	CC
cord-015021-pol2qm74	5564	26	before	before	IN
cord-015021-pol2qm74	5564	27	tile	tile	NN
cord-015021-pol2qm74	5564	28	need	need	NN
cord-015021-pol2qm74	5564	29	for	for	IN
cord-015021-pol2qm74	5564	30	external	external	JJ
cord-015021-pol2qm74	5564	31	supporl	supporl	NN
cord-015021-pol2qm74	5564	32	dovelope	dovelope	NNP
cord-015021-pol2qm74	5564	33	.	.	.
cord-015021-pol2qm74	5565	1	This	this	DT
cord-015021-pol2qm74	5565	2	could	could	MD
cord-015021-pol2qm74	5565	3	lead	lead	VB
cord-015021-pol2qm74	5565	4	to	to	IN
cord-015021-pol2qm74	5565	5	hatter	hatter	NN
cord-015021-pol2qm74	5565	6	methods	method	NNS
cord-015021-pol2qm74	5565	7	of	of	IN
cord-015021-pol2qm74	5565	8	preventing	prevent	VBG
cord-015021-pol2qm74	5565	9	organ	organ	NN
cord-015021-pol2qm74	5565	10	failure	failure	NN
cord-015021-pol2qm74	5565	11	.	.	.
cord-015021-pol2qm74	5566	1	Preveution	preveution	NN
cord-015021-pol2qm74	5566	2	is	be	VBZ
cord-015021-pol2qm74	5566	3	ultimately	ultimately	RB
cord-015021-pol2qm74	5566	4	the	the	DT
cord-015021-pol2qm74	5566	5	only	only	JJ
cord-015021-pol2qm74	5566	6	answer	answer	NN
cord-015021-pol2qm74	5566	7	to	to	IN
cord-015021-pol2qm74	5566	8	organ	organ	NN
cord-015021-pol2qm74	5566	9	failure	failure	NN
cord-015021-pol2qm74	5566	10	,	,	,
cord-015021-pol2qm74	5566	11	m	m	NNP
cord-015021-pol2qm74	5566	12	MOF	MOF	NNP
cord-015021-pol2qm74	5566	13	,	,	,
cord-015021-pol2qm74	5566	14	MODS	MODS	NNP
cord-015021-pol2qm74	5566	15	and	and	CC
cord-015021-pol2qm74	5566	16	SIRS	sir	NNS
cord-015021-pol2qm74	5566	17	.	.	.
cord-015021-pol2qm74	5567	1	Have	have	VBP
cord-015021-pol2qm74	5567	2	wo	wo	MD
cord-015021-pol2qm74	5567	3	reached	reach	VBN
cord-015021-pol2qm74	5567	4	a	a	DT
cord-015021-pol2qm74	5567	5	consensus?--Only	consensus?--only	NN
cord-015021-pol2qm74	5567	6	that	that	WDT
cord-015021-pol2qm74	5567	7	we	-PRON-	PRP
cord-015021-pol2qm74	5567	8	arc	arc	VBP
cord-015021-pol2qm74	5567	9	dealing	deal	VBG
cord-015021-pol2qm74	5567	10	wilh	wilh	NNP
cord-015021-pol2qm74	5567	11	a	a	DT
cord-015021-pol2qm74	5567	12	diffl	diffl	NNP
cord-015021-pol2qm74	5568	1	~x	~x	NNP
cord-015021-pol2qm74	5568	2	:	:	:
cord-015021-pol2qm74	5568	3	lt	lt	NNP
cord-015021-pol2qm74	5568	4	probtolR	probtolR	NNP
cord-015021-pol2qm74	5568	5	looking	look	VBG
cord-015021-pol2qm74	5568	6	for	for	IN
cord-015021-pol2qm74	5568	7	solutlons	solutlon	NNS
cord-015021-pol2qm74	5568	8	.	.	.
cord-015021-pol2qm74	5569	1	Acute	acute	JJ
cord-015021-pol2qm74	5569	2	lung	lung	NN
cord-015021-pol2qm74	5569	3	injury	injury	NN
cord-015021-pol2qm74	5569	4	(	(	-LRB-
cord-015021-pol2qm74	5569	5	ALI	ALI	NNP
cord-015021-pol2qm74	5569	6	)	)	-RRB-
cord-015021-pol2qm74	5569	7	and	and	CC
cord-015021-pol2qm74	5569	8	its	-PRON-	PRP$
cord-015021-pol2qm74	5569	9	most	most	RBS
cord-015021-pol2qm74	5569	10	severe	severe	JJ
cord-015021-pol2qm74	5569	11	form	form	NN
cord-015021-pol2qm74	5569	12	,	,	,
cord-015021-pol2qm74	5569	13	acute	acute	JJ
cord-015021-pol2qm74	5569	14	respiratory	respiratory	JJ
cord-015021-pol2qm74	5569	15	distress	distress	NN
cord-015021-pol2qm74	5569	16	syndrome	syndrome	NN
cord-015021-pol2qm74	5569	17	(	(	-LRB-
cord-015021-pol2qm74	5569	18	ARDS	ARDS	NNP
cord-015021-pol2qm74	5569	19	)	)	-RRB-
cord-015021-pol2qm74	5569	20	characterized	characterize	VBN
cord-015021-pol2qm74	5569	21	by	by	IN
cord-015021-pol2qm74	5569	22	severe	severe	JJ
cord-015021-pol2qm74	5569	23	hypoxemia	hypoxemia	NN
cord-015021-pol2qm74	5569	24	,	,	,
cord-015021-pol2qm74	5569	25	diffuse	diffuse	VB
cord-015021-pol2qm74	5569	26	infiltration	infiltration	NN
cord-015021-pol2qm74	5569	27	of	of	IN
cord-015021-pol2qm74	5569	28	both	both	DT
cord-015021-pol2qm74	5569	29	lungs	lung	NNS
cord-015021-pol2qm74	5569	30	,	,	,
cord-015021-pol2qm74	5569	31	a	a	DT
cord-015021-pol2qm74	5569	32	reduction	reduction	NN
cord-015021-pol2qm74	5569	33	of	of	IN
cord-015021-pol2qm74	5569	34	compliance	compliance	NN
cord-015021-pol2qm74	5569	35	and	and	CC
cord-015021-pol2qm74	5569	36	a	a	DT
cord-015021-pol2qm74	5569	37	wedgepresure	wedgepresure	NN
cord-015021-pol2qm74	5570	1	lower	low	JJR
cord-015021-pol2qm74	5570	2	than	than	IN
cord-015021-pol2qm74	5570	3	18	18	CD
cord-015021-pol2qm74	5570	4	mm	mm	NNP
cord-015021-pol2qm74	5570	5	Hare	Hare	NNP
cord-015021-pol2qm74	5570	6	related	relate	VBD
cord-015021-pol2qm74	5570	7	to	to	IN
cord-015021-pol2qm74	5570	8	direct	direct	JJ
cord-015021-pol2qm74	5570	9	or	or	CC
cord-015021-pol2qm74	5570	10	indirect	indirect	JJ
cord-015021-pol2qm74	5570	11	injury	injury	NN
cord-015021-pol2qm74	5570	12	.	.	.
cord-015021-pol2qm74	5571	1	When	when	WRB
cord-015021-pol2qm74	5571	2	ALIresults	ALIresults	NNP
cord-015021-pol2qm74	5571	3	from	from	IN
cord-015021-pol2qm74	5571	4	direct	direct	JJ
cord-015021-pol2qm74	5571	5	injury	injury	NN
cord-015021-pol2qm74	5571	6	(	(	-LRB-
cord-015021-pol2qm74	5571	7	toxic	toxic	JJ
cord-015021-pol2qm74	5571	8	agents	agent	NNS
cord-015021-pol2qm74	5571	9	,	,	,
cord-015021-pol2qm74	5571	10	lung	lung	NN
cord-015021-pol2qm74	5571	11	contusion	contusion	NN
cord-015021-pol2qm74	5571	12	,	,	,
cord-015021-pol2qm74	5571	13	pneumonia	pneumonia	NN
cord-015021-pol2qm74	5571	14	)	)	-RRB-
cord-015021-pol2qm74	5571	15	,	,	,
cord-015021-pol2qm74	5571	16	the	the	DT
cord-015021-pol2qm74	5571	17	lesions	lesion	NNS
cord-015021-pol2qm74	5571	18	of	of	IN
cord-015021-pol2qm74	5571	19	epithelial	epithelial	JJ
cord-015021-pol2qm74	5571	20	barrier	barrier	NN
cord-015021-pol2qm74	5571	21	and	and	CC
cord-015021-pol2qm74	5571	22	the	the	DT
cord-015021-pol2qm74	5571	23	activation	activation	NN
cord-015021-pol2qm74	5571	24	of	of	IN
cord-015021-pol2qm74	5571	25	lung	lung	NN
cord-015021-pol2qm74	5571	26	macrophages	macrophage	NNS
cord-015021-pol2qm74	5571	27	are	be	VBP
cord-015021-pol2qm74	5571	28	the	the	DT
cord-015021-pol2qm74	5571	29	first	first	JJ
cord-015021-pol2qm74	5571	30	events	event	NNS
cord-015021-pol2qm74	5571	31	leading	lead	VBG
cord-015021-pol2qm74	5571	32	to	to	IN
cord-015021-pol2qm74	5571	33	the	the	DT
cord-015021-pol2qm74	5571	34	release	release	NN
cord-015021-pol2qm74	5571	35	of	of	IN
cord-015021-pol2qm74	5571	36	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5571	37	mediators	mediator	NNS
cord-015021-pol2qm74	5571	38	wh	wh	NN
cord-015021-pol2qm74	5571	39	:	:	:
cord-015021-pol2qm74	5571	40	ch	ch	NNP
cord-015021-pol2qm74	5571	41	are	be	VBP
cord-015021-pol2qm74	5571	42	responsible	responsible	JJ
cord-015021-pol2qm74	5571	43	for	for	IN
cord-015021-pol2qm74	5571	44	alteration	alteration	NN
cord-015021-pol2qm74	5571	45	of	of	IN
cord-015021-pol2qm74	5571	46	the	the	DT
cord-015021-pol2qm74	5571	47	membranar	membranar	NNP
cord-015021-pol2qm74	5571	48	permeability	permeability	NN
cord-015021-pol2qm74	5571	49	and	and	CC
cord-015021-pol2qm74	5571	50	for	for	IN
cord-015021-pol2qm74	5571	51	invasion	invasion	NN
cord-015021-pol2qm74	5571	52	of	of	IN
cord-015021-pol2qm74	5571	53	the	the	DT
cord-015021-pol2qm74	5571	54	alveoli	alveolus	NNS
cord-015021-pol2qm74	5571	55	by	by	IN
cord-015021-pol2qm74	5571	56	fluids	fluid	NNS
cord-015021-pol2qm74	5571	57	,	,	,
cord-015021-pol2qm74	5571	58	proteins	protein	NNS
cord-015021-pol2qm74	5571	59	and	and	CC
cord-015021-pol2qm74	5571	60	cells	cell	NNS
cord-015021-pol2qm74	5571	61	.	.	.
cord-015021-pol2qm74	5572	1	An	an	DT
cord-015021-pol2qm74	5572	2	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5572	3	reaction	reaction	NN
cord-015021-pol2qm74	5572	4	develops	develop	VBZ
cord-015021-pol2qm74	5572	5	,	,	,
cord-015021-pol2qm74	5572	6	with	with	IN
cord-015021-pol2qm74	5572	7	injury	injury	NN
cord-015021-pol2qm74	5572	8	to	to	IN
cord-015021-pol2qm74	5572	9	endothelial	endothelial	JJ
cord-015021-pol2qm74	5572	10	cells	cell	NNS
cord-015021-pol2qm74	5572	11	,	,	,
cord-015021-pol2qm74	5572	12	adhesion	adhesion	NN
cord-015021-pol2qm74	5572	13	of	of	IN
cord-015021-pol2qm74	5572	14	polymorpbonuclear	polymorpbonuclear	NNP
cord-015021-pol2qm74	5572	15	leucocytes	leucocytes	NNP
cord-015021-pol2qm74	5572	16	(	(	-LRB-
cord-015021-pol2qm74	5572	17	PMN	PMN	NNP
cord-015021-pol2qm74	5572	18	)	)	-RRB-
cord-015021-pol2qm74	5572	19	and	and	CC
cord-015021-pol2qm74	5572	20	the	the	DT
cord-015021-pol2qm74	5572	21	release	release	NN
cord-015021-pol2qm74	5572	22	in	in	IN
cord-015021-pol2qm74	5572	23	blood	blood	NN
cord-015021-pol2qm74	5572	24	stream	stream	NN
cord-015021-pol2qm74	5572	25	of	of	IN
cord-015021-pol2qm74	5572	26	intlammatory	intlammatory	JJ
cord-015021-pol2qm74	5572	27	mediators	mediator	NNS
cord-015021-pol2qm74	5572	28	dispersing	disperse	VBG
cord-015021-pol2qm74	5572	29	the	the	DT
cord-015021-pol2qm74	5572	30	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5572	31	reaction	reaction	NN
cord-015021-pol2qm74	5572	32	to	to	IN
cord-015021-pol2qm74	5572	33	other	other	JJ
cord-015021-pol2qm74	5572	34	organs	organ	NNS
cord-015021-pol2qm74	5572	35	and	and	CC
cord-015021-pol2qm74	5572	36	tissues	tissue	NNS
cord-015021-pol2qm74	5572	37	.	.	.
cord-015021-pol2qm74	5573	1	The	the	DT
cord-015021-pol2qm74	5573	2	failure	failure	NN
cord-015021-pol2qm74	5573	3	of	of	IN
cord-015021-pol2qm74	5573	4	lung	lung	NN
cord-015021-pol2qm74	5573	5	function	function	NN
cord-015021-pol2qm74	5573	6	also	also	RB
cord-015021-pol2qm74	5573	7	results	result	VBZ
cord-015021-pol2qm74	5573	8	into	into	IN
cord-015021-pol2qm74	5573	9	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5573	10	in	in	IN
cord-015021-pol2qm74	5573	11	other	other	JJ
cord-015021-pol2qm74	5573	12	organs	organ	NNS
cord-015021-pol2qm74	5573	13	,	,	,
cord-015021-pol2qm74	5573	14	leading	lead	VBG
cord-015021-pol2qm74	5573	15	to	to	IN
cord-015021-pol2qm74	5573	16	tissular	tissular	JJ
cord-015021-pol2qm74	5573	17	ischemia	ischemia	NN
cord-015021-pol2qm74	5573	18	,	,	,
cord-015021-pol2qm74	5573	19	triggering	trigger	VBG
cord-015021-pol2qm74	5573	20	an	an	DT
cord-015021-pol2qm74	5573	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5573	22	reaction	reaction	NN
cord-015021-pol2qm74	5573	23	leading	lead	VBG
cord-015021-pol2qm74	5573	24	to	to	IN
cord-015021-pol2qm74	5573	25	organ	organ	NN
cord-015021-pol2qm74	5573	26	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5573	27	.	.	.
cord-015021-pol2qm74	5574	1	Frequent	frequent	JJ
cord-015021-pol2qm74	5574	2	complications	complication	NNS
cord-015021-pol2qm74	5574	3	of	of	IN
cord-015021-pol2qm74	5574	4	direct	direct	JJ
cord-015021-pol2qm74	5574	5	lung	lung	NN
cord-015021-pol2qm74	5574	6	injury	injury	NN
cord-015021-pol2qm74	5574	7	are	be	VBP
cord-015021-pol2qm74	5574	8	septic	septic	JJ
cord-015021-pol2qm74	5574	9	pneumonia	pneumonia	NN
cord-015021-pol2qm74	5574	10	with	with	IN
cord-015021-pol2qm74	5574	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5574	12	release	release	NN
cord-015021-pol2qm74	5574	13	,	,	,
cord-015021-pol2qm74	5574	14	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	5574	15	activation	activation	NN
cord-015021-pol2qm74	5574	16	and	and	CC
cord-015021-pol2qm74	5574	17	cytokine	cytokine	NN
cord-015021-pol2qm74	5574	18	production	production	NN
cord-015021-pol2qm74	5574	19	disseminating	disseminate	VBG
cord-015021-pol2qm74	5574	20	inflammation	inflammation	NN
cord-015021-pol2qm74	5574	21	.	.	.
cord-015021-pol2qm74	5575	1	By	by	IN
cord-015021-pol2qm74	5575	2	this	this	DT
cord-015021-pol2qm74	5575	3	way	way	NN
cord-015021-pol2qm74	5575	4	,	,	,
cord-015021-pol2qm74	5575	5	direct	direct	JJ
cord-015021-pol2qm74	5575	6	lung	lung	NN
cord-015021-pol2qm74	5575	7	injury	injury	NN
cord-015021-pol2qm74	5575	8	can	can	MD
cord-015021-pol2qm74	5575	9	be	be	VB
cord-015021-pol2qm74	5575	10	at	at	IN
cord-015021-pol2qm74	5575	11	the	the	DT
cord-015021-pol2qm74	5575	12	origin	origin	NN
cord-015021-pol2qm74	5575	13	of	of	IN
cord-015021-pol2qm74	5575	14	the	the	DT
cord-015021-pol2qm74	5575	15	multiple	multiple	JJ
cord-015021-pol2qm74	5575	16	organ	organ	NN
cord-015021-pol2qm74	5575	17	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5575	18	syndrome	syndrome	NN
cord-015021-pol2qm74	5575	19	(	(	-LRB-
cord-015021-pol2qm74	5575	20	MODS	MODS	NNP
cord-015021-pol2qm74	5575	21	)	)	-RRB-
cord-015021-pol2qm74	5575	22	,	,	,
cord-015021-pol2qm74	5575	23	the	the	DT
cord-015021-pol2qm74	5575	24	frequence	frequence	NN
cord-015021-pol2qm74	5575	25	of	of	IN
cord-015021-pol2qm74	5575	26	which	which	WDT
cord-015021-pol2qm74	5575	27	having	have	VBG
cord-015021-pol2qm74	5575	28	been	be	VBN
cord-015021-pol2qm74	5575	29	estimated	estimate	VBN
cord-015021-pol2qm74	5575	30	to	to	IN
cord-015021-pol2qm74	5575	31	40	40	CD
cord-015021-pol2qm74	5575	32	%	%	NN
cord-015021-pol2qm74	5575	33	and	and	CC
cord-015021-pol2qm74	5575	34	is	be	VBZ
cord-015021-pol2qm74	5575	35	increased	increase	VBN
cord-015021-pol2qm74	5575	36	when	when	WRB
cord-015021-pol2qm74	5575	37	ALl	all	DT
cord-015021-pol2qm74	5575	38	has	have	VBZ
cord-015021-pol2qm74	5575	39	occured	occur	VBN
cord-015021-pol2qm74	5575	40	in	in	IN
cord-015021-pol2qm74	5575	41	patients	patient	NNS
cord-015021-pol2qm74	5575	42	alreadypresenting	alreadypresente	VBG
cord-015021-pol2qm74	5575	43	an	an	DT
cord-015021-pol2qm74	5575	44	organ	organ	NN
cord-015021-pol2qm74	5575	45	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5575	46	(	(	-LRB-
cord-015021-pol2qm74	5575	47	immunodepresslon	immunodepresslon	NNP
cord-015021-pol2qm74	5575	48	,	,	,
cord-015021-pol2qm74	5575	49	cancer	cancer	NN
cord-015021-pol2qm74	5575	50	...	...	NFP
cord-015021-pol2qm74	5575	51	)	)	-RRB-
cord-015021-pol2qm74	5575	52	.	.	.
cord-015021-pol2qm74	5576	1	When	when	WRB
cord-015021-pol2qm74	5576	2	ALI	ALI	NNP
cord-015021-pol2qm74	5576	3	results	result	VBZ
cord-015021-pol2qm74	5576	4	from	from	IN
cord-015021-pol2qm74	5576	5	redirect	redirect	NN
cord-015021-pol2qm74	5576	6	or	or	CC
cord-015021-pol2qm74	5576	7	extrathoraclc	extrathoraclc	JJ
cord-015021-pol2qm74	5576	8	injury	injury	NN
cord-015021-pol2qm74	5576	9	(	(	-LRB-
cord-015021-pol2qm74	5576	10	trauma	trauma	NN
cord-015021-pol2qm74	5576	11	,	,	,
cord-015021-pol2qm74	5576	12	infections	infection	NNS
cord-015021-pol2qm74	5576	13	,	,	,
cord-015021-pol2qm74	5576	14	hypovolemic	hypovolemic	JJ
cord-015021-pol2qm74	5576	15	shock	shock	NN
cord-015021-pol2qm74	5576	16	,	,	,
cord-015021-pol2qm74	5576	17	acute	acute	JJ
cord-015021-pol2qm74	5576	18	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	5576	19	...	...	NFP
cord-015021-pol2qm74	5576	20	)	)	-RRB-
cord-015021-pol2qm74	5576	21	,	,	,
cord-015021-pol2qm74	5576	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5576	23	mediators	mediator	NNS
cord-015021-pol2qm74	5576	24	and	and	CC
cord-015021-pol2qm74	5576	25	micro	micro	NNS
cord-015021-pol2qm74	5576	26	-	-	HYPH
cord-015021-pol2qm74	5576	27	aggregates	aggregate	NNS
cord-015021-pol2qm74	5576	28	released	release	VBN
cord-015021-pol2qm74	5576	29	in	in	IN
cord-015021-pol2qm74	5576	30	particular	particular	JJ
cord-015021-pol2qm74	5576	31	organs	organ	NNS
cord-015021-pol2qm74	5576	32	or	or	CC
cord-015021-pol2qm74	5576	33	tissues	tissue	NNS
cord-015021-pol2qm74	5576	34	reach	reach	VB
cord-015021-pol2qm74	5576	35	the	the	DT
cord-015021-pol2qm74	5576	36	lung	lung	NN
cord-015021-pol2qm74	5576	37	via	via	IN
cord-015021-pol2qm74	5576	38	the	the	DT
cord-015021-pol2qm74	5576	39	blood	blood	NN
cord-015021-pol2qm74	5576	40	and	and	CC
cord-015021-pol2qm74	5576	41	lymph	lymph	NN
cord-015021-pol2qm74	5576	42	streams	stream	NNS
cord-015021-pol2qm74	5576	43	,	,	,
cord-015021-pol2qm74	5576	44	are	be	VBP
cord-015021-pol2qm74	5576	45	filtered	filter	VBN
cord-015021-pol2qm74	5576	46	in	in	IN
cord-015021-pol2qm74	5576	47	the	the	DT
cord-015021-pol2qm74	5576	48	organ	organ	NN
cord-015021-pol2qm74	5576	49	or	or	CC
cord-015021-pol2qm74	5576	50	trapped	trap	VBN
cord-015021-pol2qm74	5576	51	in	in	IN
cord-015021-pol2qm74	5576	52	the	the	DT
cord-015021-pol2qm74	5576	53	lung	lung	NN
cord-015021-pol2qm74	5576	54	capillaries	capillary	NNS
cord-015021-pol2qm74	5576	55	,	,	,
cord-015021-pol2qm74	5576	56	and	and	CC
cord-015021-pol2qm74	5576	57	are	be	VBP
cord-015021-pol2qm74	5576	58	responsible	responsible	JJ
cord-015021-pol2qm74	5576	59	for	for	IN
cord-015021-pol2qm74	5576	60	a	a	DT
cord-015021-pol2qm74	5576	61	local	local	JJ
cord-015021-pol2qm74	5576	62	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5576	63	reactaon	reactaon	NNS
cord-015021-pol2qm74	5576	64	(	(	-LRB-
cord-015021-pol2qm74	5576	65	endothelial	endothelial	JJ
cord-015021-pol2qm74	5576	66	cell	cell	NN
cord-015021-pol2qm74	5576	67	activation	activation	NN
cord-015021-pol2qm74	5576	68	,	,	,
cord-015021-pol2qm74	5576	69	PMN	pmn	NN
cord-015021-pol2qm74	5576	70	trapping	trapping	NN
cord-015021-pol2qm74	5576	71	and	and	CC
cord-015021-pol2qm74	5576	72	adhesion	adhesion	NN
cord-015021-pol2qm74	5576	73	,	,	,
cord-015021-pol2qm74	5576	74	platelet	platelet	NN
cord-015021-pol2qm74	5576	75	aggregation	aggregation	NN
cord-015021-pol2qm74	5576	76	,	,	,
cord-015021-pol2qm74	5576	77	release	release	NN
cord-015021-pol2qm74	5576	78	of	of	IN
cord-015021-pol2qm74	5576	79	mediators	mediator	NNS
cord-015021-pol2qm74	5576	80	)	)	-RRB-
cord-015021-pol2qm74	5576	81	.	.	.
cord-015021-pol2qm74	5577	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	5577	2	acts	act	NNS
cord-015021-pol2qm74	5577	3	by	by	IN
cord-015021-pol2qm74	5577	4	the	the	DT
cord-015021-pol2qm74	5577	5	way	way	NN
cord-015021-pol2qm74	5577	6	of	of	IN
cord-015021-pol2qm74	5577	7	endotoxiu	endotoxiu	NN
cord-015021-pol2qm74	5577	8	and	and	CC
cord-015021-pol2qm74	5577	9	sequential	sequential	JJ
cord-015021-pol2qm74	5577	10	eytokines	eytokine	NNS
cord-015021-pol2qm74	5577	11	release	release	NN
cord-015021-pol2qm74	5577	12	(	(	-LRB-
cord-015021-pol2qm74	5577	13	TNF	TNF	NNP
cord-015021-pol2qm74	5577	14	,	,	,
cord-015021-pol2qm74	5577	15	ILl	ILl	NNP
cord-015021-pol2qm74	5577	16	,	,	,
cord-015021-pol2qm74	5577	17	...	...	NFP
cord-015021-pol2qm74	5577	18	)	)	-RRB-
cord-015021-pol2qm74	5577	19	while	while	IN
cord-015021-pol2qm74	5577	20	trauma	trauma	NN
cord-015021-pol2qm74	5577	21	with	with	IN
cord-015021-pol2qm74	5577	22	important	important	JJ
cord-015021-pol2qm74	5577	23	blood	blood	NN
cord-015021-pol2qm74	5577	24	loss	loss	NN
cord-015021-pol2qm74	5577	25	acts	act	NNS
cord-015021-pol2qm74	5577	26	especially	especially	RB
cord-015021-pol2qm74	5577	27	by	by	IN
cord-015021-pol2qm74	5577	28	the	the	DT
cord-015021-pol2qm74	5577	29	way	way	NN
cord-015021-pol2qm74	5577	30	of	of	IN
cord-015021-pol2qm74	5577	31	hypoperfusionreperfusion	hypoperfusionreperfusion	NN
cord-015021-pol2qm74	5577	32	phenomena	phenomenon	NNS
cord-015021-pol2qm74	5577	33	leading	lead	VBG
cord-015021-pol2qm74	5577	34	to	to	IN
cord-015021-pol2qm74	5577	35	a	a	DT
cord-015021-pol2qm74	5577	36	disseminatedinflammatory	disseminatedinflammatory	JJ
cord-015021-pol2qm74	5577	37	reaction	reaction	NN
cord-015021-pol2qm74	5577	38	and	and	CC
cord-015021-pol2qm74	5577	39	to	to	IN
cord-015021-pol2qm74	5577	40	a	a	DT
cord-015021-pol2qm74	5577	41	possible	possible	JJ
cord-015021-pol2qm74	5577	42	bacterial	bacterial	JJ
cord-015021-pol2qm74	5577	43	transloeation	transloeation	NN
cord-015021-pol2qm74	5577	44	when	when	WRB
cord-015021-pol2qm74	5577	45	intestinal	intestinal	JJ
cord-015021-pol2qm74	5577	46	hypopeffnsion	hypopeffnsion	NN
cord-015021-pol2qm74	5577	47	is	be	VBZ
cord-015021-pol2qm74	5577	48	present	present	JJ
cord-015021-pol2qm74	5577	49	.	.	.
cord-015021-pol2qm74	5578	1	In	in	IN
cord-015021-pol2qm74	5578	2	these	these	DT
cord-015021-pol2qm74	5578	3	conditions	condition	NNS
cord-015021-pol2qm74	5578	4	of	of	IN
cord-015021-pol2qm74	5578	5	indirect	indirect	JJ
cord-015021-pol2qm74	5578	6	injury	injury	NN
cord-015021-pol2qm74	5578	7	,	,	,
cord-015021-pol2qm74	5578	8	ALl	all	DT
cord-015021-pol2qm74	5578	9	(	(	-LRB-
cord-015021-pol2qm74	5578	10	or	or	CC
cord-015021-pol2qm74	5578	11	ARDS	ARDS	NNP
cord-015021-pol2qm74	5578	12	)	)	-RRB-
cord-015021-pol2qm74	5578	13	is	be	VBZ
cord-015021-pol2qm74	5578	14	a	a	DT
cord-015021-pol2qm74	5578	15	Iocal	Iocal	NNP
cord-015021-pol2qm74	5578	16	early	early	RB
cord-015021-pol2qm74	5578	17	(	(	-LRB-
cord-015021-pol2qm74	5578	18	often	often	RB
cord-015021-pol2qm74	5578	19	the	the	DT
cord-015021-pol2qm74	5578	20	first	first	JJ
cord-015021-pol2qm74	5578	21	)	)	-RRB-
cord-015021-pol2qm74	5578	22	manifestation	manifestation	NN
cord-015021-pol2qm74	5578	23	of	of	IN
cord-015021-pol2qm74	5578	24	a	a	DT
cord-015021-pol2qm74	5578	25	general	general	JJ
cord-015021-pol2qm74	5578	26	phenomenon	phenomenon	NN
cord-015021-pol2qm74	5578	27	of	of	IN
cord-015021-pol2qm74	5578	28	altered	alter	VBN
cord-015021-pol2qm74	5578	29	membrane	membrane	NN
cord-015021-pol2qm74	5578	30	permeability	permeability	NN
cord-015021-pol2qm74	5578	31	and	and	CC
cord-015021-pol2qm74	5578	32	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5578	33	reaction	reaction	NN
cord-015021-pol2qm74	5578	34	,	,	,
cord-015021-pol2qm74	5578	35	easily	easily	RB
cord-015021-pol2qm74	5578	36	and	and	CC
cord-015021-pol2qm74	5578	37	rapidly	rapidly	RB
cord-015021-pol2qm74	5578	38	recognized	recognize	VBN
cord-015021-pol2qm74	5578	39	by	by	IN
cord-015021-pol2qm74	5578	40	its	-PRON-	PRP$
cord-015021-pol2qm74	5578	41	clin	clin	NNP
cord-015021-pol2qm74	5578	42	~	~	NNP
cord-015021-pol2qm74	5578	43	cai	cai	NNP
cord-015021-pol2qm74	5578	44	signs	sign	NNS
cord-015021-pol2qm74	5578	45	.	.	.
cord-015021-pol2qm74	5579	1	The	the	DT
cord-015021-pol2qm74	5579	2	iung	iung	NNP
cord-015021-pol2qm74	5579	3	is	be	VBZ
cord-015021-pol2qm74	5579	4	one	one	CD
cord-015021-pol2qm74	5579	5	of	of	IN
cord-015021-pol2qm74	5579	6	the	the	DT
cord-015021-pol2qm74	5579	7	numerous	numerous	JJ
cord-015021-pol2qm74	5579	8	organs	organ	NNS
cord-015021-pol2qm74	5579	9	participating	participate	VBG
cord-015021-pol2qm74	5579	10	to	to	IN
cord-015021-pol2qm74	5579	11	the	the	DT
cord-015021-pol2qm74	5579	12	MODS	mods	NN
cord-015021-pol2qm74	5579	13	,	,	,
cord-015021-pol2qm74	5579	14	In	in	IN
cord-015021-pol2qm74	5579	15	these	these	DT
cord-015021-pol2qm74	5579	16	conditions	condition	NNS
cord-015021-pol2qm74	5579	17	,	,	,
cord-015021-pol2qm74	5579	18	the	the	DT
cord-015021-pol2qm74	5579	19	mortality	mortality	NN
cord-015021-pol2qm74	5579	20	rate	rate	NN
cord-015021-pol2qm74	5579	21	is	be	VBZ
cord-015021-pol2qm74	5579	22	high	high	JJ
cord-015021-pol2qm74	5579	23	,	,	,
cord-015021-pol2qm74	5579	24	reaching	reach	VBG
cord-015021-pol2qm74	5579	25	more	more	JJR
cord-015021-pol2qm74	5579	26	than	than	IN
cord-015021-pol2qm74	5579	27	80	80	CD
cord-015021-pol2qm74	5579	28	%	%	NN
cord-015021-pol2qm74	5579	29	when	when	WRB
cord-015021-pol2qm74	5579	30	sepsis	sepsis	NN
cord-015021-pol2qm74	5579	31	is	be	VBZ
cord-015021-pol2qm74	5579	32	present	present	JJ
cord-015021-pol2qm74	5579	33	or	or	CC
cord-015021-pol2qm74	5579	34	when	when	WRB
cord-015021-pol2qm74	5579	35	at	at	RB
cord-015021-pol2qm74	5579	36	least	least	JJS
cord-015021-pol2qm74	5579	37	3	3	CD
cord-015021-pol2qm74	5579	38	organs	organ	NNS
cord-015021-pol2qm74	5579	39	are	be	VBP
cord-015021-pol2qm74	5579	40	implicated	implicate	VBN
cord-015021-pol2qm74	5579	41	in	in	IN
cord-015021-pol2qm74	5579	42	MODS	mods	NN
cord-015021-pol2qm74	5579	43	.	.	.
cord-015021-pol2qm74	5580	1	By	by	IN
cord-015021-pol2qm74	5580	2	direct	direct	JJ
cord-015021-pol2qm74	5580	3	or	or	CC
cord-015021-pol2qm74	5580	4	redirect	redirect	VB
cord-015021-pol2qm74	5580	5	injury	injury	NN
cord-015021-pol2qm74	5580	6	,	,	,
cord-015021-pol2qm74	5580	7	lung	lung	NN
cord-015021-pol2qm74	5580	8	is	be	VBZ
cord-015021-pol2qm74	5580	9	so	so	RB
cord-015021-pol2qm74	5580	10	a	a	DT
cord-015021-pol2qm74	5580	11	target	target	NN
cord-015021-pol2qm74	5580	12	organ	organ	NN
cord-015021-pol2qm74	5580	13	for	for	IN
cord-015021-pol2qm74	5580	14	MODS	mods	NN
cord-015021-pol2qm74	5580	15	and	and	CC
cord-015021-pol2qm74	5580	16	injured	injured	JJ
cord-015021-pol2qm74	5580	17	lung	lung	NN
cord-015021-pol2qm74	5580	18	can	can	MD
cord-015021-pol2qm74	5580	19	be	be	VB
cord-015021-pol2qm74	5580	20	the	the	DT
cord-015021-pol2qm74	5580	21	cause	cause	NN
cord-015021-pol2qm74	5580	22	of	of	IN
cord-015021-pol2qm74	5580	23	MODS	mods	NN
cord-015021-pol2qm74	5580	24	or	or	CC
cord-015021-pol2qm74	5580	25	simply	simply	RB
cord-015021-pol2qm74	5580	26	a	a	DT
cord-015021-pol2qm74	5580	27	participant	participant	NN
cord-015021-pol2qm74	5580	28	to	to	IN
cord-015021-pol2qm74	5580	29	this	this	DT
cord-015021-pol2qm74	5580	30	syndrome	syndrome	NN
cord-015021-pol2qm74	5580	31	.	.	.
cord-015021-pol2qm74	5581	1	Jorge	Jorge	NNP
cord-015021-pol2qm74	5581	2	Cervts	Cervts	NNP
cord-015021-pol2qm74	5581	3	-	-	HYPH
cord-015021-pol2qm74	5581	4	Navarro	Navarro	NNP
cord-015021-pol2qm74	5581	5	Main	Main	NNP
cord-015021-pol2qm74	5581	6	determinants	determinant	NNS
cord-015021-pol2qm74	5581	7	for	for	IN
cord-015021-pol2qm74	5581	8	brain	brain	NN
cord-015021-pol2qm74	5581	9	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5581	10	are	be	VBP
cord-015021-pol2qm74	5581	11	breakdown	breakdown	NN
cord-015021-pol2qm74	5581	12	of	of	IN
cord-015021-pol2qm74	5581	13	the	the	DT
cord-015021-pol2qm74	5581	14	blood	blood	NN
cord-015021-pol2qm74	5581	15	-	-	HYPH
cord-015021-pol2qm74	5581	16	brainbarrier	brainbarrier	NN
cord-015021-pol2qm74	5581	17	and	and	CC
cord-015021-pol2qm74	5581	18	raise	raise	VB
cord-015021-pol2qm74	5581	19	of	of	IN
cord-015021-pol2qm74	5581	20	intracranial	intracranial	JJ
cord-015021-pol2qm74	5581	21	pressure	pressure	NN
cord-015021-pol2qm74	5581	22	(	(	-LRB-
cord-015021-pol2qm74	5581	23	ICP	ICP	NNP
cord-015021-pol2qm74	5581	24	)	)	-RRB-
cord-015021-pol2qm74	5581	25	,	,	,
cord-015021-pol2qm74	5581	26	in	in	IN
cord-015021-pol2qm74	5581	27	second	second	JJ
cord-015021-pol2qm74	5581	28	place	place	NN
cord-015021-pol2qm74	5581	29	decrease	decrease	NN
cord-015021-pol2qm74	5581	30	of	of	IN
cord-015021-pol2qm74	5581	31	systemic	systemic	JJ
cord-015021-pol2qm74	5581	32	blood	blood	NN
cord-015021-pol2qm74	5581	33	pressure	pressure	NN
cord-015021-pol2qm74	5581	34	,	,	,
cord-015021-pol2qm74	5581	35	disorders	disorder	NNS
cord-015021-pol2qm74	5581	36	of	of	IN
cord-015021-pol2qm74	5581	37	blood	blood	NN
cord-015021-pol2qm74	5581	38	coagulation	coagulation	NN
cord-015021-pol2qm74	5581	39	and	and	CC
cord-015021-pol2qm74	5581	40	respiratory	respiratory	JJ
cord-015021-pol2qm74	5581	41	function	function	NN
cord-015021-pol2qm74	5581	42	.	.	.
cord-015021-pol2qm74	5582	1	The	the	DT
cord-015021-pol2qm74	5582	2	blood	blood	NN
cord-015021-pol2qm74	5582	3	-	-	HYPH
cord-015021-pol2qm74	5582	4	brain	brain	NN
cord-015021-pol2qm74	5582	5	-	-	HYPH
cord-015021-pol2qm74	5582	6	barrier	barrier	NN
cord-015021-pol2qm74	5582	7	of	of	IN
cord-015021-pol2qm74	5582	8	cerebral	cerebral	JJ
cord-015021-pol2qm74	5582	9	blood	blood	NN
cord-015021-pol2qm74	5582	10	vessels	vessel	NNS
cord-015021-pol2qm74	5582	11	can	can	MD
cord-015021-pol2qm74	5582	12	be	be	VB
cord-015021-pol2qm74	5582	13	opened	open	VBN
cord-015021-pol2qm74	5582	14	by	by	IN
cord-015021-pol2qm74	5582	15	stroke	stroke	NN
cord-015021-pol2qm74	5582	16	,	,	,
cord-015021-pol2qm74	5582	17	cerebral	cerebral	JJ
cord-015021-pol2qm74	5582	18	trauma	trauma	NN
cord-015021-pol2qm74	5582	19	,	,	,
cord-015021-pol2qm74	5582	20	inflammation	inflammation	NN
cord-015021-pol2qm74	5582	21	,	,	,
cord-015021-pol2qm74	5582	22	convulsions	convulsion	NNS
cord-015021-pol2qm74	5582	23	,	,	,
cord-015021-pol2qm74	5582	24	acute	acute	JJ
cord-015021-pol2qm74	5582	25	hypertension	hypertension	NN
cord-015021-pol2qm74	5582	26	and	and	CC
cord-015021-pol2qm74	5582	27	changes	change	NNS
cord-015021-pol2qm74	5582	28	in	in	IN
cord-015021-pol2qm74	5582	29	the	the	DT
cord-015021-pol2qm74	5582	30	blood	blood	NN
cord-015021-pol2qm74	5582	31	osmolarity	osmolarity	NN
cord-015021-pol2qm74	5582	32	.	.	.
cord-015021-pol2qm74	5583	1	The	the	DT
cord-015021-pol2qm74	5583	2	consequence	consequence	NN
cord-015021-pol2qm74	5583	3	is	be	VBZ
cord-015021-pol2qm74	5583	4	brain	brain	NN
cord-015021-pol2qm74	5583	5	oedema	oedema	NN
cord-015021-pol2qm74	5583	6	,	,	,
cord-015021-pol2qm74	5583	7	increase	increase	NN
cord-015021-pol2qm74	5583	8	of	of	IN
cord-015021-pol2qm74	5583	9	lOP	lOP	NNS
cord-015021-pol2qm74	5583	10	and	and	CC
cord-015021-pol2qm74	5583	11	decrease	decrease	NN
cord-015021-pol2qm74	5583	12	of	of	IN
cord-015021-pol2qm74	5583	13	the	the	DT
cord-015021-pol2qm74	5583	14	perfusion	perfusion	NN
cord-015021-pol2qm74	5583	15	pressure	pressure	NN
cord-015021-pol2qm74	5583	16	.	.	.
cord-015021-pol2qm74	5584	1	A	a	DT
cord-015021-pol2qm74	5584	2	close	close	JJ
cord-015021-pol2qm74	5584	3	correlation	correlation	NN
cord-015021-pol2qm74	5584	4	between	between	IN
cord-015021-pol2qm74	5584	5	intraventricular	intraventricular	JJ
cord-015021-pol2qm74	5584	6	pressure	pressure	NN
cord-015021-pol2qm74	5584	7	and	and	CC
cord-015021-pol2qm74	5584	8	the	the	DT
cord-015021-pol2qm74	5584	9	fate	fate	NN
cord-015021-pol2qm74	5584	10	of	of	IN
cord-015021-pol2qm74	5584	11	patients	patient	NNS
cord-015021-pol2qm74	5584	12	with	with	IN
cord-015021-pol2qm74	5584	13	severe	severe	JJ
cord-015021-pol2qm74	5584	14	brain	brain	NN
cord-015021-pol2qm74	5584	15	injuries	injury	NNS
cord-015021-pol2qm74	5584	16	has	have	VBZ
cord-015021-pol2qm74	5584	17	been	be	VBN
cord-015021-pol2qm74	5584	18	established	establish	VBN
cord-015021-pol2qm74	5584	19	.	.	.
cord-015021-pol2qm74	5585	1	Regional	regional	JJ
cord-015021-pol2qm74	5585	2	CBF	CBF	NNP
cord-015021-pol2qm74	5585	3	values	value	NNS
cord-015021-pol2qm74	5585	4	of	of	IN
cord-015021-pol2qm74	5585	5	16	16	CD
cord-015021-pol2qm74	5585	6	to	to	TO
cord-015021-pol2qm74	5585	7	18	18	CD
cord-015021-pol2qm74	5585	8	ml/100g	ml/100g	CD
cord-015021-pol2qm74	5585	9	/	/	SYM
cord-015021-pol2qm74	5585	10	min	min	NN
cord-015021-pol2qm74	5585	11	are	be	VBP
cord-015021-pol2qm74	5585	12	reflected	reflect	VBN
cord-015021-pol2qm74	5585	13	in	in	IN
cord-015021-pol2qm74	5585	14	isoelectric	isoelectric	JJ
cord-015021-pol2qm74	5585	15	EEG	EEG	NNP
cord-015021-pol2qm74	5585	16	,	,	,
cord-015021-pol2qm74	5585	17	and	and	CC
cord-015021-pol2qm74	5585	18	values	value	NNS
cord-015021-pol2qm74	5585	19	about	about	IN
cord-015021-pol2qm74	5585	20	t5ml/100g	t5ml/100g	NN
cord-015021-pol2qm74	5585	21	/	/	SYM
cord-015021-pol2qm74	5585	22	min	min	NN
cord-015021-pol2qm74	5585	23	,	,	,
cord-015021-pol2qm74	5585	24	result	result	VB
cord-015021-pol2qm74	5585	25	in	in	IN
cord-015021-pol2qm74	5585	26	loss	loss	NN
cord-015021-pol2qm74	5585	27	of	of	IN
cord-015021-pol2qm74	5585	28	somatosensory	somatosensory	NN
cord-015021-pol2qm74	5585	29	evoked	evoke	VBN
cord-015021-pol2qm74	5585	30	potentials	potential	NNS
cord-015021-pol2qm74	5585	31	.	.	.
cord-015021-pol2qm74	5586	1	For	for	IN
cord-015021-pol2qm74	5586	2	ionic	ionic	JJ
cord-015021-pol2qm74	5586	3	pump	pump	NN
cord-015021-pol2qm74	5586	4	failure	failure	NN
cord-015021-pol2qm74	5586	5	the	the	DT
cord-015021-pol2qm74	5586	6	threshold	threshold	NN
cord-015021-pol2qm74	5586	7	has	have	VBZ
cord-015021-pol2qm74	5586	8	been	be	VBN
cord-015021-pol2qm74	5586	9	determined	determine	VBN
cord-015021-pol2qm74	5586	10	by	by	IN
cord-015021-pol2qm74	5586	11	values	value	NNS
cord-015021-pol2qm74	5586	12	of	of	IN
cord-015021-pol2qm74	5586	13	about	about	RB
cord-015021-pol2qm74	5586	14	10	10	CD
cord-015021-pol2qm74	5586	15	ml/100g	ml/100g	CD
cord-015021-pol2qm74	5586	16	/	/	SYM
cord-015021-pol2qm74	5586	17	min	min	NN
cord-015021-pol2qm74	5586	18	and	and	CC
cord-015021-pol2qm74	5586	19	is	be	VBZ
cord-015021-pol2qm74	5586	20	reflected	reflect	VBN
cord-015021-pol2qm74	5586	21	in	in	IN
cord-015021-pol2qm74	5586	22	massive	massive	JJ
cord-015021-pol2qm74	5586	23	release	release	NN
cord-015021-pol2qm74	5586	24	of	of	IN
cord-015021-pol2qm74	5586	25	intracellular	intracellular	JJ
cord-015021-pol2qm74	5586	26	potassium	potassium	NN
cord-015021-pol2qm74	5586	27	.	.	.
cord-015021-pol2qm74	5587	1	In	in	IN
cord-015021-pol2qm74	5587	2	stroke	stroke	NN
cord-015021-pol2qm74	5587	3	and	and	CC
cord-015021-pol2qm74	5587	4	in	in	IN
cord-015021-pol2qm74	5587	5	brain	brain	NN
cord-015021-pol2qm74	5587	6	trauma	trauma	NN
cord-015021-pol2qm74	5587	7	when	when	WRB
cord-015021-pol2qm74	5587	8	the	the	DT
cord-015021-pol2qm74	5587	9	oedematogenous	oedematogenous	JJ
cord-015021-pol2qm74	5587	10	condition	condition	NN
cord-015021-pol2qm74	5587	11	is	be	VBZ
cord-015021-pol2qm74	5587	12	initially	initially	RB
cord-015021-pol2qm74	5587	13	localized	localize	VBN
cord-015021-pol2qm74	5587	14	the	the	DT
cord-015021-pol2qm74	5587	15	tissue	tissue	NN
cord-015021-pol2qm74	5587	16	pressure	pressure	NN
cord-015021-pol2qm74	5587	17	variance	variance	NN
cord-015021-pol2qm74	5587	18	within	within	IN
cord-015021-pol2qm74	5587	19	and	and	CC
cord-015021-pol2qm74	5587	20	between	between	IN
cord-015021-pol2qm74	5587	21	the	the	DT
cord-015021-pol2qm74	5587	22	hemispheres	hemisphere	NNS
cord-015021-pol2qm74	5587	23	lead	lead	VBP
cord-015021-pol2qm74	5587	24	to	to	IN
cord-015021-pol2qm74	5587	25	tentorial	tentorial	NNP
cord-015021-pol2qm74	5587	26	and	and	CC
cord-015021-pol2qm74	5587	27	falciform	falciform	JJ
cord-015021-pol2qm74	5587	28	herniations	herniation	NNS
cord-015021-pol2qm74	5587	29	are	be	VBP
cord-015021-pol2qm74	5587	30	the	the	DT
cord-015021-pol2qm74	5587	31	common	common	JJ
cord-015021-pol2qm74	5587	32	cause	cause	NN
cord-015021-pol2qm74	5587	33	of	of	IN
cord-015021-pol2qm74	5587	34	death	death	NN
cord-015021-pol2qm74	5587	35	even	even	RB
cord-015021-pol2qm74	5587	36	before	before	IN
cord-015021-pol2qm74	5587	37	the	the	DT
cord-015021-pol2qm74	5587	38	critical	critical	JJ
cord-015021-pol2qm74	5587	39	threshold	threshold	NN
cord-015021-pol2qm74	5587	40	of	of	IN
cord-015021-pol2qm74	5587	41	intracranial	intracranial	JJ
cord-015021-pol2qm74	5587	42	pressure	pressure	NN
cord-015021-pol2qm74	5587	43	is	be	VBZ
cord-015021-pol2qm74	5587	44	reached	reach	VBN
cord-015021-pol2qm74	5587	45	.	.	.
cord-015021-pol2qm74	5588	1	The	the	DT
cord-015021-pol2qm74	5588	2	increase	increase	NN
cord-015021-pol2qm74	5588	3	of	of	IN
cord-015021-pol2qm74	5588	4	the	the	DT
cord-015021-pol2qm74	5588	5	ICP	ICP	NNP
cord-015021-pol2qm74	5588	6	over	over	IN
cord-015021-pol2qm74	5588	7	the	the	DT
cord-015021-pol2qm74	5588	8	level	level	NN
cord-015021-pol2qm74	5588	9	of	of	IN
cord-015021-pol2qm74	5588	10	the	the	DT
cord-015021-pol2qm74	5588	11	perfusion	perfusion	NN
cord-015021-pol2qm74	5588	12	pressure	pressure	NN
cord-015021-pol2qm74	5588	13	leads	lead	VBZ
cord-015021-pol2qm74	5588	14	to	to	IN
cord-015021-pol2qm74	5588	15	the	the	DT
cord-015021-pol2qm74	5588	16	arrest	arrest	NN
cord-015021-pol2qm74	5588	17	of	of	IN
cord-015021-pol2qm74	5588	18	the	the	DT
cord-015021-pol2qm74	5588	19	CBF	CBF	NNP
cord-015021-pol2qm74	5588	20	.	.	.
cord-015021-pol2qm74	5589	1	If	if	IN
cord-015021-pol2qm74	5589	2	this	this	DT
cord-015021-pol2qm74	5589	3	persists	persist	VBZ
cord-015021-pol2qm74	5589	4	{	{	-LRB-
cord-015021-pol2qm74	5589	5	or	or	CC
cord-015021-pol2qm74	5589	6	periods	period	NNS
cord-015021-pol2qm74	5589	7	exceeding	exceed	VBG
cord-015021-pol2qm74	5589	8	6	6	CD
cord-015021-pol2qm74	5589	9	seconds	second	NNS
cord-015021-pol2qm74	5589	10	of	of	IN
cord-015021-pol2qm74	5589	11	global	global	JJ
cord-015021-pol2qm74	5589	12	brain	brain	NN
cord-015021-pol2qm74	5589	13	ischemia	ischemia	NN
cord-015021-pol2qm74	5589	14	loss	loss	NN
cord-015021-pol2qm74	5589	15	of	of	IN
cord-015021-pol2qm74	5589	16	conciousness	conciousness	NN
cord-015021-pol2qm74	5589	17	and	and	CC
cord-015021-pol2qm74	5589	18	developing	develop	VBG
cord-015021-pol2qm74	5589	19	seizures	seizure	NNS
cord-015021-pol2qm74	5589	20	appear	appear	VBP
cord-015021-pol2qm74	5589	21	.	.	.
cord-015021-pol2qm74	5590	1	If	if	IN
cord-015021-pol2qm74	5590	2	it	-PRON-	PRP
cord-015021-pol2qm74	5590	3	exceeds	exceed	VBZ
cord-015021-pol2qm74	5590	4	10	10	CD
cord-015021-pol2qm74	5590	5	min	min	NN
cord-015021-pol2qm74	5590	6	irreversible	irreversible	JJ
cord-015021-pol2qm74	5590	7	injuries	injury	NNS
cord-015021-pol2qm74	5590	8	of	of	IN
cord-015021-pol2qm74	5590	9	the	the	DT
cord-015021-pol2qm74	5590	10	brain	brain	NN
cord-015021-pol2qm74	5590	11	appear	appear	VBP
cord-015021-pol2qm74	5590	12	.	.	.
cord-015021-pol2qm74	5591	1	Following	follow	VBG
cord-015021-pol2qm74	5591	2	cerebral	cerebral	JJ
cord-015021-pol2qm74	5591	3	ischemia	ischemia	NN
cord-015021-pol2qm74	5591	4	and	and	CC
cord-015021-pol2qm74	5591	5	after	after	IN
cord-015021-pol2qm74	5591	6	severe	severe	JJ
cord-015021-pol2qm74	5591	7	head	head	NN
cord-015021-pol2qm74	5591	8	injury	injury	NN
cord-015021-pol2qm74	5591	9	a	a	DT
cord-015021-pol2qm74	5591	10	tendency	tendency	NN
cord-015021-pol2qm74	5591	11	to	to	IN
cord-015021-pol2qm74	5591	12	increased	increase	VBN
cord-015021-pol2qm74	5591	13	coagulation	coagulation	NN
cord-015021-pol2qm74	5591	14	can	can	MD
cord-015021-pol2qm74	5591	15	be	be	VB
cord-015021-pol2qm74	5591	16	detected	detect	VBN
cord-015021-pol2qm74	5591	17	.	.	.
cord-015021-pol2qm74	5592	1	Vascular	vascular	JJ
cord-015021-pol2qm74	5592	2	occlusion	occlusion	NN
cord-015021-pol2qm74	5592	3	may	may	MD
cord-015021-pol2qm74	5592	4	develop	develop	VB
cord-015021-pol2qm74	5592	5	either	either	CC
cord-015021-pol2qm74	5592	6	as	as	IN
cord-015021-pol2qm74	5592	7	a	a	DT
cord-015021-pol2qm74	5592	8	result	result	NN
cord-015021-pol2qm74	5592	9	of	of	IN
cord-015021-pol2qm74	5592	10	local	local	JJ
cord-015021-pol2qm74	5592	11	thrombus	thrombus	NN
cord-015021-pol2qm74	5592	12	formation	formation	NN
cord-015021-pol2qm74	5592	13	or	or	CC
cord-015021-pol2qm74	5592	14	from	from	IN
cord-015021-pol2qm74	5592	15	emboli	embolus	NNS
cord-015021-pol2qm74	5592	16	caused	cause	VBN
cord-015021-pol2qm74	5592	17	by	by	IN
cord-015021-pol2qm74	5592	18	circulating	circulate	VBG
cord-015021-pol2qm74	5592	19	platelet	platelet	NN
cord-015021-pol2qm74	5592	20	aggregates	aggregate	NNS
cord-015021-pol2qm74	5592	21	.	.	.
cord-015021-pol2qm74	5593	1	The	the	DT
cord-015021-pol2qm74	5593	2	formation	formation	NN
cord-015021-pol2qm74	5593	3	of	of	IN
cord-015021-pol2qm74	5593	4	microthrombi	microthrombi	NNP
cord-015021-pol2qm74	5593	5	is	be	VBZ
cord-015021-pol2qm74	5593	6	triggered	trigger	VBN
cord-015021-pol2qm74	5593	7	by	by	IN
cord-015021-pol2qm74	5593	8	the	the	DT
cord-015021-pol2qm74	5593	9	plateletactivating	plateletactivating	NN
cord-015021-pol2qm74	5593	10	factor	factor	NN
cord-015021-pol2qm74	5593	11	a	a	DT
cord-015021-pol2qm74	5593	12	mediator	mediator	NN
cord-015021-pol2qm74	5593	13	in	in	IN
cord-015021-pol2qm74	5593	14	central	central	JJ
cord-015021-pol2qm74	5593	15	nervous	nervous	JJ
cord-015021-pol2qm74	5593	16	injury	injury	NN
cord-015021-pol2qm74	5593	17	also	also	RB
cord-015021-pol2qm74	5593	18	responsible	responsible	JJ
cord-015021-pol2qm74	5593	19	for	for	IN
cord-015021-pol2qm74	5593	20	aggravation	aggravation	NN
cord-015021-pol2qm74	5593	21	of	of	IN
cord-015021-pol2qm74	5593	22	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	5593	23	brain	brain	NN
cord-015021-pol2qm74	5593	24	edema	edema	NN
cord-015021-pol2qm74	5593	25	.	.	.
cord-015021-pol2qm74	5594	1	Acute	acute	JJ
cord-015021-pol2qm74	5594	2	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5594	3	leucoencephalitis	leucoencephalitis	NN
cord-015021-pol2qm74	5594	4	and	and	CC
cord-015021-pol2qm74	5594	5	brain	brain	NN
cord-015021-pol2qm74	5594	6	purpura	purpura	NN
cord-015021-pol2qm74	5594	7	are	be	VBP
cord-015021-pol2qm74	5594	8	known	know	VBN
cord-015021-pol2qm74	5594	9	to	to	TO
cord-015021-pol2qm74	5594	10	arise	arise	VB
cord-015021-pol2qm74	5594	11	as	as	IN
cord-015021-pol2qm74	5594	12	complications	complication	NNS
cord-015021-pol2qm74	5594	13	of	of	IN
cord-015021-pol2qm74	5594	14	acute	acute	JJ
cord-015021-pol2qm74	5594	15	viral	viral	JJ
cord-015021-pol2qm74	5594	16	infections	infection	NNS
cord-015021-pol2qm74	5594	17	and	and	CC
cord-015021-pol2qm74	5594	18	following	follow	VBG
cord-015021-pol2qm74	5594	19	Gram	gram	NN
cord-015021-pol2qm74	5594	20	-	-	HYPH
cord-015021-pol2qm74	5594	21	negative	negative	JJ
cord-015021-pol2qm74	5594	22	septicaemia	septicaemia	NN
cord-015021-pol2qm74	5594	23	.	.	.
cord-015021-pol2qm74	5595	1	Institute	Institute	NNP
cord-015021-pol2qm74	5595	2	of	of	IN
cord-015021-pol2qm74	5595	3	Neuropathology	Neuropathology	NNP
cord-015021-pol2qm74	5595	4	,	,	,
cord-015021-pol2qm74	5595	5	Free	Free	NNP
cord-015021-pol2qm74	5595	6	University	University	NNP
cord-015021-pol2qm74	5595	7	of	of	IN
cord-015021-pol2qm74	5595	8	Berlin	Berlin	NNP
cord-015021-pol2qm74	5595	9	,	,	,
cord-015021-pol2qm74	5595	10	Hindenburgdamm	Hindenburgdamm	NNP
cord-015021-pol2qm74	5595	11	30	30	CD
cord-015021-pol2qm74	5595	12	,	,	,
cord-015021-pol2qm74	5595	13	12200	12200	CD
cord-015021-pol2qm74	5595	14	Berlin	Berlin	NNP
cord-015021-pol2qm74	5595	15	,	,	,
cord-015021-pol2qm74	5595	16	Germany	Germany	NNP
cord-015021-pol2qm74	5595	17	Undoubtedly	Undoubtedly	NNP
cord-015021-pol2qm74	5595	18	,	,	,
cord-015021-pol2qm74	5595	19	attempts	attempt	VBZ
cord-015021-pol2qm74	5595	20	to	to	TO
cord-015021-pol2qm74	5595	21	quantify	quantify	VB
cord-015021-pol2qm74	5595	22	as	as	RB
cord-015021-pol2qm74	5595	23	objectively	objectively	RB
cord-015021-pol2qm74	5595	24	as	as	IN
cord-015021-pol2qm74	5595	25	possible	possible	JJ
cord-015021-pol2qm74	5596	1	the	the	DT
cord-015021-pol2qm74	5596	2	degree	degree	NN
cord-015021-pol2qm74	5596	3	of	of	IN
cord-015021-pol2qm74	5596	4	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5596	5	of	of	IN
cord-015021-pol2qm74	5596	6	the	the	DT
cord-015021-pol2qm74	5596	7	various	various	JJ
cord-015021-pol2qm74	5596	8	organs	organ	NNS
cord-015021-pol2qm74	5596	9	is	be	VBZ
cord-015021-pol2qm74	5596	10	very	very	RB
cord-015021-pol2qm74	5596	11	valuable	valuable	JJ
cord-015021-pol2qm74	5596	12	.	.	.
cord-015021-pol2qm74	5597	1	However	however	RB
cord-015021-pol2qm74	5597	2	,	,	,
cord-015021-pol2qm74	5597	3	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	5597	4	failure	failure	NN
cord-015021-pol2qm74	5597	5	has	have	VBZ
cord-015021-pol2qm74	5597	6	a	a	DT
cord-015021-pol2qm74	5597	7	peculiar	peculiar	JJ
cord-015021-pol2qm74	5597	8	place	place	NN
cord-015021-pol2qm74	5597	9	in	in	IN
cord-015021-pol2qm74	5597	10	the	the	DT
cord-015021-pol2qm74	5597	11	context	context	NN
cord-015021-pol2qm74	5597	12	of	of	IN
cord-015021-pol2qm74	5597	13	sepsis	sepsis	NN
cord-015021-pol2qm74	5597	14	.	.	.
cord-015021-pol2qm74	5598	1	The	the	DT
cord-015021-pol2qm74	5598	2	development	development	NN
cord-015021-pol2qm74	5598	3	of	of	IN
cord-015021-pol2qm74	5598	4	acute	acute	JJ
cord-015021-pol2qm74	5598	5	circulatory	circulatory	JJ
cord-015021-pol2qm74	5598	6	failure	failure	NN
cord-015021-pol2qm74	5598	7	(	(	-LRB-
cord-015021-pol2qm74	5598	8	shock	shock	NN
cord-015021-pol2qm74	5598	9	)	)	-RRB-
cord-015021-pol2qm74	5598	10	is	be	VBZ
cord-015021-pol2qm74	5598	11	of	of	IN
cord-015021-pol2qm74	5598	12	paramount	paramount	JJ
cord-015021-pol2qm74	5598	13	importance	importance	NN
cord-015021-pol2qm74	5598	14	as	as	IN
cord-015021-pol2qm74	5598	15	a	a	DT
cord-015021-pol2qm74	5598	16	cause	cause	NN
cord-015021-pol2qm74	5598	17	rather	rather	RB
cord-015021-pol2qm74	5598	18	than	than	IN
cord-015021-pol2qm74	5598	19	as	as	IN
cord-015021-pol2qm74	5598	20	a	a	DT
cord-015021-pol2qm74	5598	21	consequence	consequence	NN
cord-015021-pol2qm74	5598	22	of	of	IN
cord-015021-pol2qm74	5598	23	organ	organ	NN
cord-015021-pol2qm74	5598	24	failure	failure	NN
cord-015021-pol2qm74	5598	25	.	.	.
cord-015021-pol2qm74	5599	1	It	-PRON-	PRP
cord-015021-pol2qm74	5599	2	is	be	VBZ
cord-015021-pol2qm74	5599	3	therefore	therefore	RB
cord-015021-pol2qm74	5599	4	essential	essential	JJ
cord-015021-pol2qm74	5599	5	to	to	TO
cord-015021-pol2qm74	5599	6	clearly	clearly	RB
cord-015021-pol2qm74	5599	7	separate	separate	VB
cord-015021-pol2qm74	5599	8	patients	patient	NNS
cord-015021-pol2qm74	5599	9	with	with	IN
cord-015021-pol2qm74	5599	10	and	and	CC
cord-015021-pol2qm74	5599	11	without	without	IN
cord-015021-pol2qm74	5599	12	circulatory	circulatory	JJ
cord-015021-pol2qm74	5599	13	failure	failure	NN
cord-015021-pol2qm74	5599	14	.	.	.
cord-015021-pol2qm74	5600	1	Once	once	RB
cord-015021-pol2qm74	5600	2	this	this	DT
cord-015021-pol2qm74	5600	3	has	have	VBZ
cord-015021-pol2qm74	5600	4	been	be	VBN
cord-015021-pol2qm74	5600	5	done	do	VBN
cord-015021-pol2qm74	5600	6	,	,	,
cord-015021-pol2qm74	5600	7	attempts	attempt	VBZ
cord-015021-pol2qm74	5600	8	to	to	TO
cord-015021-pol2qm74	5600	9	list	list	VB
cord-015021-pol2qm74	5600	10	the	the	DT
cord-015021-pol2qm74	5600	11	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	5600	12	system	system	NN
cord-015021-pol2qm74	5600	13	among	among	IN
cord-015021-pol2qm74	5600	14	the	the	DT
cord-015021-pol2qm74	5600	15	other	other	JJ
cord-015021-pol2qm74	5600	16	systems	system	NNS
cord-015021-pol2qm74	5600	17	have	have	VBP
cord-015021-pol2qm74	5600	18	been	be	VBN
cord-015021-pol2qm74	5600	19	unconvincing	unconvincing	JJ
cord-015021-pol2qm74	5600	20	.	.	.
cord-015021-pol2qm74	5601	1	In	in	IN
cord-015021-pol2qm74	5601	2	a	a	DT
cord-015021-pol2qm74	5601	3	number	number	NN
cord-015021-pol2qm74	5601	4	of	of	IN
cord-015021-pol2qm74	5601	5	studies	study	NNS
cord-015021-pol2qm74	5601	6	,	,	,
cord-015021-pol2qm74	5601	7	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	5601	8	complications	complication	NNS
cord-015021-pol2qm74	5601	9	are	be	VBP
cord-015021-pol2qm74	5601	10	assimilated	assimilate	VBN
cord-015021-pol2qm74	5601	11	to	to	IN
cord-015021-pol2qm74	5601	12	a	a	DT
cord-015021-pol2qm74	5601	13	low	low	JJ
cord-015021-pol2qm74	5601	14	systemic	systemic	JJ
cord-015021-pol2qm74	5601	15	vascular	vascular	JJ
cord-015021-pol2qm74	5601	16	resistance	resistance	NN
cord-015021-pol2qm74	5601	17	(	(	-LRB-
cord-015021-pol2qm74	5601	18	SVR	SVR	NNP
cord-015021-pol2qm74	5601	19	)	)	-RRB-
cord-015021-pol2qm74	5601	20	,	,	,
cord-015021-pol2qm74	5601	21	but	but	CC
cord-015021-pol2qm74	5601	22	since	since	IN
cord-015021-pol2qm74	5601	23	SVR	SVR	NNP
cord-015021-pol2qm74	5601	24	is	be	VBZ
cord-015021-pol2qm74	5601	25	basically	basically	RB
cord-015021-pol2qm74	5601	26	the	the	DT
cord-015021-pol2qm74	5601	27	ratio	ratio	NN
cord-015021-pol2qm74	5601	28	of	of	IN
cord-015021-pol2qm74	5601	29	blood	blood	NN
cord-015021-pol2qm74	5601	30	pressure	pressure	NN
cord-015021-pol2qm74	5601	31	over	over	IN
cord-015021-pol2qm74	5601	32	cardiac	cardiac	JJ
cord-015021-pol2qm74	5601	33	output	output	NN
cord-015021-pol2qm74	5601	34	,	,	,
cord-015021-pol2qm74	5601	35	and	and	CC
cord-015021-pol2qm74	5601	36	since	since	IN
cord-015021-pol2qm74	5601	37	hypotension	hypotension	NN
cord-015021-pol2qm74	5601	38	is	be	VBZ
cord-015021-pol2qm74	5601	39	already	already	RB
cord-015021-pol2qm74	5601	40	included	include	VBN
cord-015021-pol2qm74	5601	41	in	in	IN
cord-015021-pol2qm74	5601	42	the	the	DT
cord-015021-pol2qm74	5601	43	definition	definition	NN
cord-015021-pol2qm74	5601	44	of	of	IN
cord-015021-pol2qm74	5601	45	shock	shock	NN
cord-015021-pol2qm74	5601	46	,	,	,
cord-015021-pol2qm74	5601	47	then	then	RB
cord-015021-pol2qm74	5601	48	a	a	DT
cord-015021-pol2qm74	5601	49	low	low	JJ
cord-015021-pol2qm74	5601	50	SVR	SVR	NNP
cord-015021-pol2qm74	5601	51	is	be	VBZ
cord-015021-pol2qm74	5601	52	basically	basically	RB
cord-015021-pol2qm74	5601	53	equivalent	equivalent	JJ
cord-015021-pol2qm74	5601	54	to	to	IN
cord-015021-pol2qm74	5601	55	a	a	DT
cord-015021-pol2qm74	5601	56	high	high	JJ
cord-015021-pol2qm74	5601	57	cardiac	cardiac	JJ
cord-015021-pol2qm74	5601	58	output	output	NN
cord-015021-pol2qm74	5601	59	,	,	,
cord-015021-pol2qm74	5601	60	which	which	WDT
cord-015021-pol2qm74	5601	61	is	be	VBZ
cord-015021-pol2qm74	5601	62	a	a	DT
cord-015021-pol2qm74	5601	63	characteristic	characteristic	NN
cord-015021-pol2qm74	5601	64	rather	rather	RB
cord-015021-pol2qm74	5601	65	than	than	IN
cord-015021-pol2qm74	5601	66	an	an	DT
cord-015021-pol2qm74	5601	67	ominous	ominous	JJ
cord-015021-pol2qm74	5601	68	complication	complication	NN
cord-015021-pol2qm74	5601	69	of	of	IN
cord-015021-pol2qm74	5601	70	severe	severe	JJ
cord-015021-pol2qm74	5601	71	sepsis	sepsis	NN
cord-015021-pol2qm74	5601	72	.	.	.
cord-015021-pol2qm74	5602	1	Development	development	NN
cord-015021-pol2qm74	5602	2	of	of	IN
cord-015021-pol2qm74	5602	3	a	a	DT
cord-015021-pol2qm74	5602	4	low	low	JJ
cord-015021-pol2qm74	5602	5	cardiac	cardiac	JJ
cord-015021-pol2qm74	5602	6	output	output	NN
cord-015021-pol2qm74	5602	7	unresponsive	unresponsive	JJ
cord-015021-pol2qm74	5602	8	to	to	IN
cord-015021-pol2qm74	5602	9	fluids	fluid	NNS
cord-015021-pol2qm74	5602	10	is	be	VBZ
cord-015021-pol2qm74	5602	11	usually	usually	RB
cord-015021-pol2qm74	5602	12	a	a	DT
cord-015021-pol2qm74	5602	13	terminal	terminal	JJ
cord-015021-pol2qm74	5602	14	event	event	NN
cord-015021-pol2qm74	5602	15	.	.	.
cord-015021-pol2qm74	5603	1	It	-PRON-	PRP
cord-015021-pol2qm74	5603	2	is	be	VBZ
cord-015021-pol2qm74	5603	3	not	not	RB
cord-015021-pol2qm74	5603	4	advisable	advisable	JJ
cord-015021-pol2qm74	5603	5	to	to	TO
cord-015021-pol2qm74	5603	6	list	list	VB
cord-015021-pol2qm74	5603	7	other	other	JJ
cord-015021-pol2qm74	5603	8	problems	problem	NNS
cord-015021-pol2qm74	5603	9	such	such	JJ
cord-015021-pol2qm74	5603	10	as	as	IN
cord-015021-pol2qm74	5603	11	severe	severe	JJ
cord-015021-pol2qm74	5603	12	arrhythmias	arrhythmia	NNS
cord-015021-pol2qm74	5603	13	,	,	,
cord-015021-pol2qm74	5603	14	myocardial	myocardial	JJ
cord-015021-pol2qm74	5603	15	infarction	infarction	NN
cord-015021-pol2qm74	5603	16	or	or	CC
cord-015021-pol2qm74	5603	17	tamponade	tamponade	NN
cord-015021-pol2qm74	5603	18	as	as	IN
cord-015021-pol2qm74	5603	19	complications	complication	NNS
cord-015021-pol2qm74	5603	20	of	of	IN
cord-015021-pol2qm74	5603	21	severe	severe	JJ
cord-015021-pol2qm74	5603	22	sepsis	sepsis	NN
cord-015021-pol2qm74	5603	23	.	.	.
cord-015021-pol2qm74	5604	1	HOST	HOST	NNP
cord-015021-pol2qm74	5604	2	DEFENSE	defense	NN
cord-015021-pol2qm74	5604	3	DYSFUNCTION	dysfunction	NN
cord-015021-pol2qm74	5605	1	FOLLOWING	following	JJ
cord-015021-pol2qm74	5605	2	TRAUMA	trauma	NN
cord-015021-pol2qm74	5605	3	,	,	,
cord-015021-pol2qm74	5606	1	SHOCK	shock	NN
cord-015021-pol2qm74	5606	2	AND	and	CC
cord-015021-pol2qm74	5606	3	SEPSIS	SEPSIS	NNP
cord-015021-pol2qm74	5606	4	E.	E.	NNP
cord-015021-pol2qm74	5606	5	Faist	Faist	NNP
cord-015021-pol2qm74	5606	6	,	,	,
cord-015021-pol2qm74	5606	7	G.	G.	NNP
cord-015021-pol2qm74	5606	8	F.	F.	NNP
cord-015021-pol2qm74	5606	9	Babcock	Babcock	NNP
cord-015021-pol2qm74	5607	1	*	*	NFP
cord-015021-pol2qm74	5608	1	Major	major	JJ
cord-015021-pol2qm74	5608	2	accidental	accidental	JJ
cord-015021-pol2qm74	5608	3	,	,	,
cord-015021-pol2qm74	5608	4	burn	burn	VB
cord-015021-pol2qm74	5608	5	and	and	CC
cord-015021-pol2qm74	5608	6	operative	operative	JJ
cord-015021-pol2qm74	5608	7	injury	injury	NN
cord-015021-pol2qm74	5608	8	often	often	RB
cord-015021-pol2qm74	5608	9	precipitates	precipitate	VBZ
cord-015021-pol2qm74	5608	10	a	a	DT
cord-015021-pol2qm74	5608	11	profound	profound	JJ
cord-015021-pol2qm74	5608	12	multicentric	multicentric	JJ
cord-015021-pol2qm74	5608	13	immunologic	immunologic	JJ
cord-015021-pol2qm74	5608	14	depression	depression	NN
cord-015021-pol2qm74	5608	15	that	that	WDT
cord-015021-pol2qm74	5608	16	is	be	VBZ
cord-015021-pol2qm74	5608	17	believed	believe	VBN
cord-015021-pol2qm74	5608	18	to	to	TO
cord-015021-pol2qm74	5608	19	predispose	predispose	VB
cord-015021-pol2qm74	5608	20	patients	patient	NNS
cord-015021-pol2qm74	5608	21	to	to	TO
cord-015021-pol2qm74	5608	22	become	become	VB
cord-015021-pol2qm74	5608	23	anergic	anergic	NN
cord-015021-pol2qm74	5608	24	and	and	CC
cord-015021-pol2qm74	5608	25	thus	thus	RB
cord-015021-pol2qm74	5608	26	to	to	TO
cord-015021-pol2qm74	5608	27	develop	develop	VB
cord-015021-pol2qm74	5608	28	towards	towards	IN
cord-015021-pol2qm74	5608	29	a	a	DT
cord-015021-pol2qm74	5608	30	higb	higb	JJ
cord-015021-pol2qm74	5608	31	probability	probability	NN
cord-015021-pol2qm74	5608	32	of	of	IN
cord-015021-pol2qm74	5608	33	infection	infection	NN
cord-015021-pol2qm74	5608	34	.	.	.
cord-015021-pol2qm74	5609	1	Anergy	Anergy	NNP
cord-015021-pol2qm74	5609	2	or	or	CC
cord-015021-pol2qm74	5609	3	a	a	DT
cord-015021-pol2qm74	5609	4	lack	lack	NN
cord-015021-pol2qm74	5609	5	of	of	IN
cord-015021-pol2qm74	5609	6	immunologic	immunologic	JJ
cord-015021-pol2qm74	5609	7	reactiVity	reactivity	NN
cord-015021-pol2qm74	5609	8	stands	stand	VBZ
cord-015021-pol2qm74	5609	9	for	for	IN
cord-015021-pol2qm74	5609	10	a	a	DT
cord-015021-pol2qm74	5609	11	total	total	JJ
cord-015021-pol2qm74	5609	12	elimination	elimination	NN
cord-015021-pol2qm74	5609	13	of	of	IN
cord-015021-pol2qm74	5609	14	skin	skin	NN
cord-015021-pol2qm74	5609	15	test	test	NN
cord-015021-pol2qm74	5609	16	reactivity	reactivity	NN
cord-015021-pol2qm74	5609	17	and	and	CC
cord-015021-pol2qm74	5609	18	recall	recall	VB
cord-015021-pol2qm74	5609	19	antigen	antigen	NN
cord-015021-pol2qm74	5609	20	responses	response	NNS
cord-015021-pol2qm74	5609	21	in	in	IN
cord-015021-pol2qm74	5609	22	the	the	DT
cord-015021-pol2qm74	5609	23	inununocompromised	inununocompromised	JJ
cord-015021-pol2qm74	5609	24	patient	patient	NN
cord-015021-pol2qm74	5609	25	.	.	.
cord-015021-pol2qm74	5610	1	Anergy	Anergy	NNP
cord-015021-pol2qm74	5610	2	following	follow	VBG
cord-015021-pol2qm74	5610	3	overwhelming	overwhelming	JJ
cord-015021-pol2qm74	5610	4	trauma	trauma	NN
cord-015021-pol2qm74	5610	5	or	or	CC
cord-015021-pol2qm74	5610	6	major	major	JJ
cord-015021-pol2qm74	5610	7	septic	septic	JJ
cord-015021-pol2qm74	5610	8	conditions	condition	NNS
cord-015021-pol2qm74	5610	9	results	result	VBZ
cord-015021-pol2qm74	5610	10	from	from	IN
cord-015021-pol2qm74	5610	11	a	a	DT
cord-015021-pol2qm74	5610	12	massive	massive	JJ
cord-015021-pol2qm74	5610	13	impairment	impairment	NN
cord-015021-pol2qm74	5610	14	of	of	IN
cord-015021-pol2qm74	5610	15	cell	cell	NN
cord-015021-pol2qm74	5610	16	mediated	mediate	VBN
cord-015021-pol2qm74	5610	17	immunity	immunity	NN
cord-015021-pol2qm74	5610	18	(	(	-LRB-
cord-015021-pol2qm74	5610	19	CMI	CMI	NNP
cord-015021-pol2qm74	5610	20	)	)	-RRB-
cord-015021-pol2qm74	5610	21	together	together	RB
cord-015021-pol2qm74	5610	22	with	with	IN
cord-015021-pol2qm74	5610	23	a	a	DT
cord-015021-pol2qm74	5610	24	whole	whole	JJ
cord-015021-pol2qm74	5610	25	body	body	NN
cord-015021-pol2qm74	5610	26	malignant	malignant	JJ
cord-015021-pol2qm74	5610	27	inflammationiike	inflammationiike	JJ
cord-015021-pol2qm74	5610	28	state	state	NN
cord-015021-pol2qm74	5610	29	.	.	.
cord-015021-pol2qm74	5611	1	We	-PRON-	PRP
cord-015021-pol2qm74	5611	2	and	and	CC
cord-015021-pol2qm74	5611	3	others	other	NNS
cord-015021-pol2qm74	5611	4	have	have	VBP
cord-015021-pol2qm74	5611	5	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	5611	6	clearly	clearly	RB
cord-015021-pol2qm74	5611	7	that	that	IN
cord-015021-pol2qm74	5611	8	the	the	DT
cord-015021-pol2qm74	5611	9	skeration	skeration	NN
cord-015021-pol2qm74	5611	10	of	of	IN
cord-015021-pol2qm74	5611	11	CMI	CMI	NNP
cord-015021-pol2qm74	5611	12	following	follow	VBG
cord-015021-pol2qm74	5611	13	trauma	trauma	NN
cord-015021-pol2qm74	5611	14	is	be	VBZ
cord-015021-pol2qm74	5611	15	mainly	mainly	RB
cord-015021-pol2qm74	5611	16	due	due	JJ
cord-015021-pol2qm74	5611	17	to	to	IN
cord-015021-pol2qm74	5611	18	the	the	DT
cord-015021-pol2qm74	5611	19	disruption	disruption	NN
cord-015021-pol2qm74	5611	20	of	of	IN
cord-015021-pol2qm74	5611	21	intact	intact	JJ
cord-015021-pol2qm74	5611	22	monocyte	monocyte	NNP
cord-015021-pol2qm74	5611	23	(	(	-LRB-
cord-015021-pol2qm74	5611	24	MOO	MOO	NNP
cord-015021-pol2qm74	5611	25	)	)	-RRB-
cord-015021-pol2qm74	5611	26	/	/	SYM
cord-015021-pol2qm74	5611	27	T	t	NN
cord-015021-pol2qm74	5611	28	-	-	HYPH
cord-015021-pol2qm74	5611	29	cell	cell	NN
cord-015021-pol2qm74	5611	30	interaction	interaction	NN
cord-015021-pol2qm74	5611	31	.	.	.
cord-015021-pol2qm74	5612	1	Within	within	IN
cord-015021-pol2qm74	5612	2	this	this	DT
cord-015021-pol2qm74	5612	3	phenomenon	phenomenon	NN
cord-015021-pol2qm74	5612	4	we	-PRON-	PRP
cord-015021-pol2qm74	5612	5	see	see	VBP
cord-015021-pol2qm74	5612	6	a	a	DT
cord-015021-pol2qm74	5612	7	shift	shift	NN
cord-015021-pol2qm74	5612	8	of	of	IN
cord-015021-pol2qm74	5612	9	the	the	DT
cord-015021-pol2qm74	5612	10	cell	cell	NN
cord-015021-pol2qm74	5612	11	ratio	ratio	NN
cord-015021-pol2qm74	5612	12	in	in	IN
cord-015021-pol2qm74	5612	13	the	the	DT
cord-015021-pol2qm74	5612	14	compartment	compartment	NN
cord-015021-pol2qm74	5612	15	of	of	IN
cord-015021-pol2qm74	5612	16	peripheral	peripheral	JJ
cord-015021-pol2qm74	5612	17	blood	blood	NN
cord-015021-pol2qm74	5612	18	mononuclear	mononuclear	NN
cord-015021-pol2qm74	5612	19	cells	cell	NNS
cord-015021-pol2qm74	5612	20	(	(	-LRB-
cord-015021-pol2qm74	5612	21	PBMC	PBMC	NNP
cord-015021-pol2qm74	5612	22	)	)	-RRB-
cord-015021-pol2qm74	5612	23	with	with	IN
cord-015021-pol2qm74	5612	24	a	a	DT
cord-015021-pol2qm74	5612	25	considerable	considerable	JJ
cord-015021-pol2qm74	5612	26	increase	increase	NN
cord-015021-pol2qm74	5612	27	of	of	IN
cord-015021-pol2qm74	5612	28	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	5612	29	E	e	NN
cord-015021-pol2qm74	5612	30	2	2	CD
cord-015021-pol2qm74	5612	31	synthesizing	synthesize	VBG
cord-015021-pol2qm74	5612	32	M~	m~	NN
cord-015021-pol2qm74	5612	33	and	and	CC
cord-015021-pol2qm74	5612	34	a	a	DT
cord-015021-pol2qm74	5612	35	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	5612	36	decrease	decrease	NN
cord-015021-pol2qm74	5612	37	of	of	IN
cord-015021-pol2qm74	5612	38	functionally	functionally	RB
cord-015021-pol2qm74	5612	39	competent	competent	JJ
cord-015021-pol2qm74	5612	40	CD3	CD3	NNP
cord-015021-pol2qm74	5612	41	+	+	CC
cord-015021-pol2qm74	5612	42	and	and	CC
cord-015021-pol2qm74	5612	43	CD4	CD4	NNP
cord-015021-pol2qm74	5612	44	+	+	CC
cord-015021-pol2qm74	5612	45	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	5612	46	.	.	.
cord-015021-pol2qm74	5613	1	T	t	NN
cord-015021-pol2qm74	5613	2	-	-	HYPH
cord-015021-pol2qm74	5613	3	cell	cell	NN
cord-015021-pol2qm74	5613	4	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5613	5	in	in	IN
cord-015021-pol2qm74	5613	6	states	state	NNS
cord-015021-pol2qm74	5613	7	of	of	IN
cord-015021-pol2qm74	5613	8	profound	profound	JJ
cord-015021-pol2qm74	5613	9	stress	stress	NN
cord-015021-pol2qm74	5613	10	is	be	VBZ
cord-015021-pol2qm74	5613	11	characterized	characterize	VBN
cord-015021-pol2qm74	5613	12	by	by	IN
cord-015021-pol2qm74	5613	13	impaired	impaired	JJ
cord-015021-pol2qm74	5613	14	synthesis	synthesis	NN
cord-015021-pol2qm74	5613	15	of	of	IN
cord-015021-pol2qm74	5613	16	two	two	CD
cord-015021-pol2qm74	5613	17	crucial	crucial	JJ
cord-015021-pol2qm74	5613	18	lymphokines	lymphokine	NNS
cord-015021-pol2qm74	5613	19	-Interleukin-2	-Interleukin-2	.
cord-015021-pol2qm74	5613	20	(	(	-LRB-
cord-015021-pol2qm74	5613	21	IL-2	IL-2	NNP
cord-015021-pol2qm74	5613	22	)	)	-RRB-
cord-015021-pol2qm74	5613	23	and	and	CC
cord-015021-pol2qm74	5613	24	gamma	gamma	NN
cord-015021-pol2qm74	5613	25	-	-	HYPH
cord-015021-pol2qm74	5613	26	Interferon	Interferon	NNP
cord-015021-pol2qm74	5613	27	(	(	-LRB-
cord-015021-pol2qm74	5613	28	y	y	NNP
cord-015021-pol2qm74	5613	29	-	-	HYPH
cord-015021-pol2qm74	5613	30	IFN	IFN	NNP
cord-015021-pol2qm74	5613	31	)	)	-RRB-
cord-015021-pol2qm74	5613	32	.	.	.
cord-015021-pol2qm74	5614	1	The	the	DT
cord-015021-pol2qm74	5614	2	inability	inability	NN
cord-015021-pol2qm74	5614	3	to	to	TO
cord-015021-pol2qm74	5614	4	produce	produce	VB
cord-015021-pol2qm74	5614	5	adequate	adequate	JJ
cord-015021-pol2qm74	5614	6	amounts	amount	NNS
cord-015021-pol2qm74	5614	7	of	of	IN
cord-015021-pol2qm74	5614	8	IL-2	il-2	NN
cord-015021-pol2qm74	5614	9	,	,	,
cord-015021-pol2qm74	5614	10	most	most	RBS
cord-015021-pol2qm74	5614	11	likely	likely	RB
cord-015021-pol2qm74	5614	12	attributable	attributable	JJ
cord-015021-pol2qm74	5614	13	to	to	IN
cord-015021-pol2qm74	5614	14	alterations	alteration	NNS
cord-015021-pol2qm74	5614	15	in	in	IN
cord-015021-pol2qm74	5614	16	the	the	DT
cord-015021-pol2qm74	5614	17	transmission	transmission	NN
cord-015021-pol2qm74	5614	18	of	of	IN
cord-015021-pol2qm74	5614	19	signals	signal	NNS
cord-015021-pol2qm74	5614	20	from	from	IN
cord-015021-pol2qm74	5614	21	the	the	DT
cord-015021-pol2qm74	5614	22	cell	cell	NN
cord-015021-pol2qm74	5614	23	membrane	membrane	NN
cord-015021-pol2qm74	5614	24	to	to	IN
cord-015021-pol2qm74	5614	25	the	the	DT
cord-015021-pol2qm74	5614	26	nucleus	nucleus	NN
cord-015021-pol2qm74	5614	27	,	,	,
cord-015021-pol2qm74	5614	28	results	result	NNS
cord-015021-pol2qm74	5614	29	in	in	IN
cord-015021-pol2qm74	5614	30	incomplete	incomplete	JJ
cord-015021-pol2qm74	5614	31	proliferative	proliferative	JJ
cord-015021-pol2qm74	5614	32	T	t	NN
cord-015021-pol2qm74	5614	33	-	-	HYPH
cord-015021-pol2qm74	5614	34	cell	cell	NN
cord-015021-pol2qm74	5614	35	responses	response	NNS
cord-015021-pol2qm74	5614	36	to	to	IN
cord-015021-pol2qm74	5614	37	antigenic	antigenic	JJ
cord-015021-pol2qm74	5614	38	stimuli	stimulus	NNS
cord-015021-pol2qm74	5614	39	,	,	,
cord-015021-pol2qm74	5614	40	while	while	IN
cord-015021-pol2qm74	5614	41	a	a	DT
cord-015021-pol2qm74	5614	42	lack	lack	NN
cord-015021-pol2qm74	5614	43	of	of	IN
cord-015021-pol2qm74	5614	44	?	?	.
cord-015021-pol2qm74	5615	1	-IFN	-IFN	-LRB-
cord-015021-pol2qm74	5615	2	results	result	VBZ
cord-015021-pol2qm74	5615	3	in	in	IN
cord-015021-pol2qm74	5615	4	inadequate	inadequate	JJ
cord-015021-pol2qm74	5615	5	M~	M~	NNP
cord-015021-pol2qm74	5615	6	antigen	antigen	NN
cord-015021-pol2qm74	5615	7	processing	processing	NN
cord-015021-pol2qm74	5615	8	and	and	CC
cord-015021-pol2qm74	5615	9	presentation	presentation	NN
cord-015021-pol2qm74	5615	10	.	.	.
cord-015021-pol2qm74	5616	1	The	the	DT
cord-015021-pol2qm74	5616	2	role	role	NN
cord-015021-pol2qm74	5616	3	of	of	IN
cord-015021-pol2qm74	5616	4	the	the	DT
cord-015021-pol2qm74	5616	5	two	two	CD
cord-015021-pol2qm74	5616	6	functionally	functionally	RB
cord-015021-pol2qm74	5616	7	distinct	distinct	JJ
cord-015021-pol2qm74	5616	8	T	t	NN
cord-015021-pol2qm74	5616	9	-	-	HYPH
cord-015021-pol2qm74	5616	10	helper	helper	NN
cord-015021-pol2qm74	5616	11	subsets	subset	NNS
cord-015021-pol2qm74	5616	12	,	,	,
cord-015021-pol2qm74	5616	13	T	T	NNP
cord-015021-pol2qm74	5616	14	-	-	HYPH
cord-015021-pol2qm74	5616	15	helper-1	helper-1	NNP
cord-015021-pol2qm74	5617	1	(	(	-LRB-
cord-015021-pol2qm74	5617	2	Thl	Thl	NNP
cord-015021-pol2qm74	5617	3	)	)	-RRB-
cord-015021-pol2qm74	5617	4	secreting	secrete	VBG
cord-015021-pol2qm74	5617	5	principally	principally	RB
cord-015021-pol2qm74	5617	6	IL-2	IL-2	NNP
cord-015021-pol2qm74	5618	1	and	and	CC
cord-015021-pol2qm74	5618	2	?	?	.
cord-015021-pol2qm74	5618	3	-IFN	-ifn	ADD
cord-015021-pol2qm74	5618	4	and	and	CC
cord-015021-pol2qm74	5618	5	T	T	NNP
cord-015021-pol2qm74	5618	6	-	-	HYPH
cord-015021-pol2qm74	5618	7	helper-2	helper-2	NNP
cord-015021-pol2qm74	5618	8	(	(	-LRB-
cord-015021-pol2qm74	5618	9	Th2	Th2	NNP
cord-015021-pol2qm74	5618	10	)	)	-RRB-
cord-015021-pol2qm74	5618	11	acting	act	VBG
cord-015021-pol2qm74	5618	12	principally	principally	RB
cord-015021-pol2qm74	5618	13	in	in	IN
cord-015021-pol2qm74	5618	14	inducing	induce	VBG
cord-015021-pol2qm74	5618	15	antibody	antibody	NN
cord-015021-pol2qm74	5618	16	formation	formation	NN
cord-015021-pol2qm74	5618	17	with	with	IN
cord-015021-pol2qm74	5618	18	a	a	DT
cord-015021-pol2qm74	5618	19	secretion	secretion	NN
cord-015021-pol2qm74	5618	20	of	of	IN
cord-015021-pol2qm74	5618	21	IL-4	IL-4	NNP
cord-015021-pol2qm74	5618	22	,	,	,
cord-015021-pol2qm74	5618	23	IL-5	IL-5	NNP
cord-015021-pol2qm74	5618	24	,	,	,
cord-015021-pol2qm74	5618	25	IL-10	IL-10	NNP
cord-015021-pol2qm74	5618	26	and	and	CC
cord-015021-pol2qm74	5618	27	TNF-[3	TNF-[3	NNP
cord-015021-pol2qm74	5618	28	has	have	VBZ
cord-015021-pol2qm74	5618	29	still	still	RB
cord-015021-pol2qm74	5618	30	to	to	TO
cord-015021-pol2qm74	5618	31	be	be	VB
cord-015021-pol2qm74	5618	32	established	establish	VBN
cord-015021-pol2qm74	5618	33	within	within	IN
cord-015021-pol2qm74	5618	34	the	the	DT
cord-015021-pol2qm74	5618	35	context	context	NN
cord-015021-pol2qm74	5618	36	of	of	IN
cord-015021-pol2qm74	5618	37	major	major	JJ
cord-015021-pol2qm74	5618	38	trauma	trauma	NN
cord-015021-pol2qm74	5618	39	.	.	.
cord-015021-pol2qm74	5619	1	Antibody	antibody	NN
cord-015021-pol2qm74	5619	2	formation	formation	NN
cord-015021-pol2qm74	5619	3	to	to	IN
cord-015021-pol2qm74	5619	4	common	common	JJ
cord-015021-pol2qm74	5619	5	protein	protein	NN
cord-015021-pol2qm74	5619	6	antigens	antigen	NNS
cord-015021-pol2qm74	5619	7	is	be	VBZ
cord-015021-pol2qm74	5619	8	impaired	impair	VBN
cord-015021-pol2qm74	5619	9	,	,	,
cord-015021-pol2qm74	5619	10	the	the	DT
cord-015021-pol2qm74	5619	11	predominant	predominant	JJ
cord-015021-pol2qm74	5619	12	finding	finding	NN
cord-015021-pol2qm74	5619	13	is	be	VBZ
cord-015021-pol2qm74	5619	14	a	a	DT
cord-015021-pol2qm74	5619	15	shift	shift	NN
cord-015021-pol2qm74	5619	16	from	from	IN
cord-015021-pol2qm74	5619	17	IgM	IgM	NNP
cord-015021-pol2qm74	5619	18	to	to	IN
cord-015021-pol2qm74	5619	19	IgG	IgG	NNP
cord-015021-pol2qm74	5619	20	synthesis	synthesis	NNP
cord-015021-pol2qm74	5619	21	.	.	.
cord-015021-pol2qm74	5620	1	Although	although	IN
cord-015021-pol2qm74	5620	2	excessive	excessive	JJ
cord-015021-pol2qm74	5620	3	secretion	secretion	NN
cord-015021-pol2qm74	5620	4	of	of	IN
cord-015021-pol2qm74	5620	5	prninflammatory	prninflammatory	NN
cord-015021-pol2qm74	5620	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	5620	7	(	(	-LRB-
cord-015021-pol2qm74	5620	8	IL	IL	NNP
cord-015021-pol2qm74	5620	9	-	-	HYPH
cord-015021-pol2qm74	5620	10	U3	U3	NNP
cord-015021-pol2qm74	5620	11	,	,	,
cord-015021-pol2qm74	5620	12	TNF	TNF	NNP
cord-015021-pol2qm74	5620	13	-	-	HYPH
cord-015021-pol2qm74	5620	14	c~	c~	NNP
cord-015021-pol2qm74	5620	15	,	,	,
cord-015021-pol2qm74	5620	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	5620	17	,	,	,
cord-015021-pol2qm74	5620	18	IL-8	IL-8	NNP
cord-015021-pol2qm74	5620	19	)	)	-RRB-
cord-015021-pol2qm74	5620	20	has	have	VBZ
cord-015021-pol2qm74	5620	21	been	be	VBN
cord-015021-pol2qm74	5620	22	considered	consider	VBN
cord-015021-pol2qm74	5620	23	to	to	TO
cord-015021-pol2qm74	5620	24	be	be	VB
cord-015021-pol2qm74	5620	25	deleterious	deleterious	JJ
cord-015021-pol2qm74	5620	26	for	for	IN
cord-015021-pol2qm74	5620	27	the	the	DT
cord-015021-pol2qm74	5620	28	host	host	NN
cord-015021-pol2qm74	5620	29	in	in	IN
cord-015021-pol2qm74	5620	30	states	state	NNS
cord-015021-pol2qm74	5620	31	of	of	IN
cord-015021-pol2qm74	5620	32	major	major	JJ
cord-015021-pol2qm74	5620	33	inflammation	inflammation	NN
cord-015021-pol2qm74	5620	34	and	and	CC
cord-015021-pol2qm74	5620	35	infection	infection	NN
cord-015021-pol2qm74	5620	36	,	,	,
cord-015021-pol2qm74	5620	37	in	in	IN
cord-015021-pol2qm74	5620	38	-	-	HYPH
cord-015021-pol2qm74	5620	39	vitro	vitro	FW
cord-015021-pol2qm74	5620	40	and	and	CC
cord-015021-pol2qm74	5620	41	whole	whole	JJ
cord-015021-pol2qm74	5620	42	blood	blood	NN
cord-015021-pol2qm74	5620	43	investigation	investigation	NN
cord-015021-pol2qm74	5620	44	of	of	IN
cord-015021-pol2qm74	5620	45	Me	Me	NNP
cord-015021-pol2qm74	5620	46	function	function	NN
cord-015021-pol2qm74	5620	47	has	have	VBZ
cord-015021-pol2qm74	5620	48	clearly	clearly	RB
cord-015021-pol2qm74	5620	49	revealed	reveal	VBN
cord-015021-pol2qm74	5620	50	that	that	IN
cord-015021-pol2qm74	5620	51	there	there	EX
cord-015021-pol2qm74	5620	52	is	be	VBZ
cord-015021-pol2qm74	5620	53	initially	initially	RB
cord-015021-pol2qm74	5620	54	a	a	DT
cord-015021-pol2qm74	5620	55	marked	marked	JJ
cord-015021-pol2qm74	5620	56	suppression	suppression	NN
cord-015021-pol2qm74	5620	57	of	of	IN
cord-015021-pol2qm74	5620	58	MOO	MOO	NNP
cord-015021-pol2qm74	5620	59	from	from	IN
cord-015021-pol2qm74	5620	60	septic	septic	JJ
cord-015021-pol2qm74	5620	61	patients	patient	NNS
cord-015021-pol2qm74	5620	62	to	to	TO
cord-015021-pol2qm74	5620	63	synthesize	synthesize	VB
cord-015021-pol2qm74	5620	64	and	and	CC
cord-015021-pol2qm74	5620	65	secrete	secrete	VB
cord-015021-pol2qm74	5620	66	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	5620	67	cytokines	cytokine	NNS
cord-015021-pol2qm74	5620	68	to	to	IN
cord-015021-pol2qm74	5620	69	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5620	70	.	.	.
cord-015021-pol2qm74	5621	1	This	this	DT
cord-015021-pol2qm74	5621	2	probably	probably	RB
cord-015021-pol2qm74	5621	3	will	will	MD
cord-015021-pol2qm74	5621	4	result	result	VB
cord-015021-pol2qm74	5621	5	in	in	IN
cord-015021-pol2qm74	5621	6	immunodeficiency	immunodeficiency	NN
cord-015021-pol2qm74	5621	7	of	of	IN
cord-015021-pol2qm74	5621	8	traumatized	traumatize	VBN
cord-015021-pol2qm74	5621	9	as	as	RB
cord-015021-pol2qm74	5621	10	well	well	RB
cord-015021-pol2qm74	5621	11	as	as	IN
cord-015021-pol2qm74	5621	12	septic	septic	JJ
cord-015021-pol2qm74	5621	13	patients	patient	NNS
cord-015021-pol2qm74	5621	14	,	,	,
cord-015021-pol2qm74	5621	15	since	since	IN
cord-015021-pol2qm74	5621	16	these	these	DT
cord-015021-pol2qm74	5621	17	cytokines	cytokine	NNS
cord-015021-pol2qm74	5621	18	in	in	IN
cord-015021-pol2qm74	5621	19	low	low	JJ
cord-015021-pol2qm74	5621	20	concentrations	concentration	NNS
cord-015021-pol2qm74	5621	21	are	be	VBP
cord-015021-pol2qm74	5621	22	involved	involve	VBN
cord-015021-pol2qm74	5621	23	in	in	IN
cord-015021-pol2qm74	5621	24	the	the	DT
cord-015021-pol2qm74	5621	25	upregulation	upregulation	NN
cord-015021-pol2qm74	5621	26	of	of	IN
cord-015021-pol2qm74	5621	27	the	the	DT
cord-015021-pol2qm74	5621	28	essential	essential	JJ
cord-015021-pol2qm74	5621	29	humoral	humoral	JJ
cord-015021-pol2qm74	5621	30	and	and	CC
cord-015021-pol2qm74	5621	31	cellular	cellular	JJ
cord-015021-pol2qm74	5621	32	immune	immune	JJ
cord-015021-pol2qm74	5621	33	functions	function	NNS
cord-015021-pol2qm74	5621	34	.	.	.
cord-015021-pol2qm74	5622	1	Abnormalities	abnormality	NNS
cord-015021-pol2qm74	5622	2	of	of	IN
cord-015021-pol2qm74	5622	3	PMN	PMN	NNP
cord-015021-pol2qm74	5622	4	function	function	NN
cord-015021-pol2qm74	5622	5	noted	note	VBN
cord-015021-pol2qm74	5622	6	after	after	IN
cord-015021-pol2qm74	5622	7	serious	serious	JJ
cord-015021-pol2qm74	5622	8	injury	injury	NN
cord-015021-pol2qm74	5622	9	have	have	VBP
cord-015021-pol2qm74	5622	10	been	be	VBN
cord-015021-pol2qm74	5622	11	interpreted	interpret	VBN
cord-015021-pol2qm74	5622	12	by	by	IN
cord-015021-pol2qm74	5622	13	some	some	DT
cord-015021-pol2qm74	5622	14	investigators	investigator	NNS
cord-015021-pol2qm74	5622	15	as	as	IN
cord-015021-pol2qm74	5622	16	signs	sign	NNS
cord-015021-pol2qm74	5622	17	of	of	IN
cord-015021-pol2qm74	5622	18	unresponsiveness	unresponsiveness	NN
cord-015021-pol2qm74	5622	19	of	of	IN
cord-015021-pol2qm74	5622	20	this	this	DT
cord-015021-pol2qm74	5622	21	cell	cell	NN
cord-015021-pol2qm74	5622	22	population	population	NN
cord-015021-pol2qm74	5622	23	,	,	,
cord-015021-pol2qm74	5622	24	others	other	NNS
cord-015021-pol2qm74	5622	25	have	have	VBP
cord-015021-pol2qm74	5622	26	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	5622	27	signs	sign	NNS
cord-015021-pol2qm74	5622	28	of	of	IN
cord-015021-pol2qm74	5622	29	PMN	PMN	NNP
cord-015021-pol2qm74	5622	30	byperactivation	byperactivation	NN
cord-015021-pol2qm74	5622	31	.	.	.
cord-015021-pol2qm74	5623	1	Latest	late	JJS
cord-015021-pol2qm74	5623	2	findings	finding	NNS
cord-015021-pol2qm74	5623	3	revealed	reveal	VBD
cord-015021-pol2qm74	5623	4	that	that	IN
cord-015021-pol2qm74	5623	5	there	there	EX
cord-015021-pol2qm74	5623	6	is	be	VBZ
cord-015021-pol2qm74	5623	7	a	a	DT
cord-015021-pol2qm74	5623	8	clear	clear	JJ
cord-015021-pol2qm74	5623	9	PMN	PMN	NNP
cord-015021-pol2qm74	5623	10	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5623	11	in	in	IN
cord-015021-pol2qm74	5623	12	circulating	circulate	VBG
cord-015021-pol2qm74	5623	13	blood	blood	NN
cord-015021-pol2qm74	5623	14	:	:	:
cord-015021-pol2qm74	5623	15	70	70	CD
cord-015021-pol2qm74	5623	16	%	%	NN
cord-015021-pol2qm74	5623	17	of	of	IN
cord-015021-pol2qm74	5623	18	all	all	DT
cord-015021-pol2qm74	5623	19	PMN	PMN	NNP
cord-015021-pol2qm74	5623	20	's	's	POS
cord-015021-pol2qm74	5623	21	in	in	IN
cord-015021-pol2qm74	5623	22	this	this	DT
cord-015021-pol2qm74	5623	23	compartment	compartment	NN
cord-015021-pol2qm74	5623	24	show	show	NN
cord-015021-pol2qm74	5623	25	downregulated	downregulate	VBD
cord-015021-pol2qm74	5623	26	or	or	CC
cord-015021-pol2qm74	5623	27	non	non	AFX
cord-015021-pol2qm74	5623	28	existent	existent	JJ
cord-015021-pol2qm74	5623	29	~-integrins	~-integrin	NNS
cord-015021-pol2qm74	5623	30	within	within	IN
cord-015021-pol2qm74	5623	31	72	72	CD
cord-015021-pol2qm74	5623	32	hours	hour	NNS
cord-015021-pol2qm74	5623	33	posttrauma	posttrauma	NN
cord-015021-pol2qm74	5623	34	-these	-these	JJ
cord-015021-pol2qm74	5623	35	cells	cell	NNS
cord-015021-pol2qm74	5623	36	do	do	VBP
cord-015021-pol2qm74	5623	37	not	not	RB
cord-015021-pol2qm74	5623	38	phagocytose	phagocytose	JJ
cord-015021-pol2qm74	5623	39	,	,	,
cord-015021-pol2qm74	5623	40	have	have	VBP
cord-015021-pol2qm74	5623	41	a	a	DT
cord-015021-pol2qm74	5623	42	reduced	reduce	VBN
cord-015021-pol2qm74	5623	43	respiratory	respiratory	JJ
cord-015021-pol2qm74	5623	44	burst	burst	NN
cord-015021-pol2qm74	5623	45	and	and	CC
cord-015021-pol2qm74	5623	46	appear	appear	VB
cord-015021-pol2qm74	5623	47	to	to	TO
cord-015021-pol2qm74	5623	48	be	be	VB
cord-015021-pol2qm74	5623	49	completely	completely	RB
cord-015021-pol2qm74	5623	50	degranulated	degranulate	VBN
cord-015021-pol2qm74	5623	51	.	.	.
cord-015021-pol2qm74	5624	1	Restoration	restoration	NN
cord-015021-pol2qm74	5624	2	of	of	IN
cord-015021-pol2qm74	5624	3	these	these	DT
cord-015021-pol2qm74	5624	4	cell	cell	NN
cord-015021-pol2qm74	5624	5	functions	function	NNS
cord-015021-pol2qm74	5624	6	within	within	IN
cord-015021-pol2qm74	5624	7	7	7	CD
cord-015021-pol2qm74	5624	8	days	day	NNS
cord-015021-pol2qm74	5624	9	post	post	NN
cord-015021-pol2qm74	5624	10	-	-	NN
cord-015021-pol2qm74	5624	11	trauma	trauma	NN
cord-015021-pol2qm74	5624	12	is	be	VBZ
cord-015021-pol2qm74	5624	13	significantly	significantly	RB
cord-015021-pol2qm74	5624	14	correlated	correlate	VBN
cord-015021-pol2qm74	5624	15	to	to	IN
cord-015021-pol2qm74	5624	16	survival	survival	NN
cord-015021-pol2qm74	5624	17	of	of	IN
cord-015021-pol2qm74	5624	18	traumatized	traumatize	VBN
cord-015021-pol2qm74	5624	19	patients	patient	NNS
cord-015021-pol2qm74	5624	20	.	.	.
cord-015021-pol2qm74	5625	1	Other	other	JJ
cord-015021-pol2qm74	5625	2	reports	report	NNS
cord-015021-pol2qm74	5625	3	however	however	RB
cord-015021-pol2qm74	5625	4	stress	stress	NN
cord-015021-pol2qm74	5625	5	increased	increase	VBD
cord-015021-pol2qm74	5625	6	expression	expression	NN
cord-015021-pol2qm74	5625	7	of	of	IN
cord-015021-pol2qm74	5625	8	CR3	CR3	NNP
cord-015021-pol2qm74	5625	9	+	+	SYM
cord-015021-pol2qm74	5625	10	receptors	receptor	NNS
cord-015021-pol2qm74	5625	11	(	(	-LRB-
cord-015021-pol2qm74	5625	12	CDll	CDll	NNP
cord-015021-pol2qm74	5625	13	/	/	SYM
cord-015021-pol2qm74	5625	14	CD18	CD18	NNP
cord-015021-pol2qm74	5625	15	complex	complex	NN
cord-015021-pol2qm74	5625	16	)	)	-RRB-
cord-015021-pol2qm74	5625	17	on	on	IN
cord-015021-pol2qm74	5625	18	circulating	circulate	VBG
cord-015021-pol2qm74	5625	19	PMN	PMN	NNP
cord-015021-pol2qm74	5625	20	's	's	POS
cord-015021-pol2qm74	5625	21	,	,	,
cord-015021-pol2qm74	5625	22	increasing	increase	VBG
cord-015021-pol2qm74	5625	23	the	the	DT
cord-015021-pol2qm74	5625	24	ability	ability	NN
cord-015021-pol2qm74	5625	25	of	of	IN
cord-015021-pol2qm74	5625	26	these	these	DT
cord-015021-pol2qm74	5625	27	cells	cell	NNS
cord-015021-pol2qm74	5625	28	to	to	TO
cord-015021-pol2qm74	5625	29	adhere	adhere	VB
cord-015021-pol2qm74	5625	30	to	to	IN
cord-015021-pol2qm74	5625	31	intercellular	intercellular	JJ
cord-015021-pol2qm74	5625	32	adhesion	adhesion	NN
cord-015021-pol2qm74	5625	33	molecules	molecule	NNS
cord-015021-pol2qm74	5625	34	,	,	,
cord-015021-pol2qm74	5625	35	thus	thus	RB
cord-015021-pol2qm74	5625	36	contributing	contribute	VBG
cord-015021-pol2qm74	5625	37	to	to	TO
cord-015021-pol2qm74	5625	38	play	play	VB
cord-015021-pol2qm74	5625	39	a	a	DT
cord-015021-pol2qm74	5625	40	major	major	JJ
cord-015021-pol2qm74	5625	41	role	role	NN
cord-015021-pol2qm74	5625	42	in	in	IN
cord-015021-pol2qm74	5625	43	inducing	induce	VBG
cord-015021-pol2qm74	5625	44	the	the	DT
cord-015021-pol2qm74	5625	45	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	5625	46	capillary	capillary	JJ
cord-015021-pol2qm74	5625	47	leakage	leakage	NN
cord-015021-pol2qm74	5625	48	.	.	.
cord-015021-pol2qm74	5626	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	5626	2	knowledge	knowledge	NN
cord-015021-pol2qm74	5626	3	about	about	IN
cord-015021-pol2qm74	5626	4	the	the	DT
cord-015021-pol2qm74	5626	5	perturbation	perturbation	NN
cord-015021-pol2qm74	5626	6	of	of	IN
cord-015021-pol2qm74	5626	7	host	host	NN
cord-015021-pol2qm74	5626	8	defenses	defense	NNS
cord-015021-pol2qm74	5626	9	associated	associate	VBN
cord-015021-pol2qm74	5626	10	with	with	IN
cord-015021-pol2qm74	5626	11	serious	serious	JJ
cord-015021-pol2qm74	5626	12	injury	injury	NN
cord-015021-pol2qm74	5626	13	and	and	CC
cord-015021-pol2qm74	5626	14	sepsis	sepsis	NN
cord-015021-pol2qm74	5626	15	is	be	VBZ
cord-015021-pol2qm74	5626	16	continuously	continuously	RB
cord-015021-pol2qm74	5626	17	increasing	increase	VBG
cord-015021-pol2qm74	5626	18	and	and	CC
cord-015021-pol2qm74	5626	19	represents	represent	VBZ
cord-015021-pol2qm74	5626	20	the	the	DT
cord-015021-pol2qm74	5626	21	precondition	precondition	NN
cord-015021-pol2qm74	5626	22	for	for	IN
cord-015021-pol2qm74	5626	23	the	the	DT
cord-015021-pol2qm74	5626	24	design	design	NN
cord-015021-pol2qm74	5626	25	of	of	IN
cord-015021-pol2qm74	5626	26	effective	effective	JJ
cord-015021-pol2qm74	5626	27	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	5626	28	measures	measure	NNS
cord-015021-pol2qm74	5626	29	to	to	TO
cord-015021-pol2qm74	5626	30	prevent	prevent	VB
cord-015021-pol2qm74	5626	31	and	and	CC
cord-015021-pol2qm74	5626	32	counteract	counteract	VB
cord-015021-pol2qm74	5626	33	the	the	DT
cord-015021-pol2qm74	5626	34	resistance	resistance	NN
cord-015021-pol2qm74	5626	35	to	to	IN
cord-015021-pol2qm74	5626	36	invading	invade	VBG
cord-015021-pol2qm74	5626	37	microorganisms	microorganism	NNS
cord-015021-pol2qm74	5626	38	.	.	.
cord-015021-pol2qm74	5627	1	Dept	Dept	NNP
cord-015021-pol2qm74	5627	2	.	.	NNP
cord-015021-pol2qm74	5627	3	of	of	IN
cord-015021-pol2qm74	5627	4	Surgery	surgery	NN
cord-015021-pol2qm74	5627	5	,	,	,
cord-015021-pol2qm74	5627	6	Klinikum	Klinikum	NNP
cord-015021-pol2qm74	5627	7	Grosshadern	Grosshadern	NNP
cord-015021-pol2qm74	5627	8	,	,	,
cord-015021-pol2qm74	5627	9	Ludwig	Ludwig	NNP
cord-015021-pol2qm74	5627	10	-	-	HYPH
cord-015021-pol2qm74	5627	11	Maximilians	Maximilians	NNP
cord-015021-pol2qm74	5627	12	-	-	HYPH
cord-015021-pol2qm74	5627	13	University	University	NNP
cord-015021-pol2qm74	5627	14	,	,	,
cord-015021-pol2qm74	5627	15	Munich	Munich	NNP
cord-015021-pol2qm74	5627	16	,	,	,
cord-015021-pol2qm74	5627	17	Germany	Germany	NNP
cord-015021-pol2qm74	5627	18	.	.	.
cord-015021-pol2qm74	5628	1	*	*	NFP
cord-015021-pol2qm74	5628	2	Dept	Dept	NNP
cord-015021-pol2qm74	5628	3	.	.	NNP
cord-015021-pol2qm74	5628	4	of	of	IN
cord-015021-pol2qm74	5628	5	Surgery	Surgery	NNP
cord-015021-pol2qm74	5628	6	,	,	,
cord-015021-pol2qm74	5628	7	University	University	NNP
cord-015021-pol2qm74	5628	8	of	of	IN
cord-015021-pol2qm74	5628	9	Cincinnati	Cincinnati	NNP
cord-015021-pol2qm74	5628	10	,	,	,
cord-015021-pol2qm74	5628	11	Cincinnati	Cincinnati	NNP
cord-015021-pol2qm74	5628	12	,	,	,
cord-015021-pol2qm74	5628	13	Ohio	Ohio	NNP
cord-015021-pol2qm74	5628	14	,	,	,
cord-015021-pol2qm74	5628	15	USA	USA	NNP
cord-015021-pol2qm74	5628	16	LG	LG	NNP
cord-015021-pol2qm74	5628	17	Thijs~	Thijs~	NNP
cord-015021-pol2qm74	5629	1	CE	CE	NNP
cord-015021-pol2qm74	5629	2	N	N	NNP
cord-015021-pol2qm74	5630	1	~ck	~ck	NNP
cord-015021-pol2qm74	5630	2	Sepsis	sepsis	NN
cord-015021-pol2qm74	5630	3	is	be	VBZ
cord-015021-pol2qm74	5630	4	the	the	DT
cord-015021-pol2qm74	5630	5	most	most	RBS
cord-015021-pol2qm74	5630	6	common	common	JJ
cord-015021-pol2qm74	5630	7	cause	cause	NN
cord-015021-pol2qm74	5630	8	of	of	IN
cord-015021-pol2qm74	5630	9	acute	acute	JJ
cord-015021-pol2qm74	5630	10	disseminated	disseminate	VBN
cord-015021-pol2qm74	5630	11	intravascular	intravascular	JJ
cord-015021-pol2qm74	5630	12	coagulation	coagulation	NN
cord-015021-pol2qm74	5630	13	(	(	-LRB-
cord-015021-pol2qm74	5630	14	DIC	DIC	NNP
cord-015021-pol2qm74	5630	15	)	)	-RRB-
cord-015021-pol2qm74	5630	16	and	and	CC
cord-015021-pol2qm74	5630	17	coagulation	coagulation	NN
cord-015021-pol2qm74	5630	18	disorders	disorder	NNS
cord-015021-pol2qm74	5630	19	as	as	RB
cord-015021-pol2qm74	5630	20	well	well	RB
cord-015021-pol2qm74	5630	21	as	as	IN
cord-015021-pol2qm74	5631	1	abnormalities	abnormality	NNS
cord-015021-pol2qm74	5631	2	of	of	IN
cord-015021-pol2qm74	5631	3	fibrinolysis	fibrinolysis	NN
cord-015021-pol2qm74	5631	4	are	be	VBP
cord-015021-pol2qm74	5631	5	common	common	JJ
cord-015021-pol2qm74	5631	6	in	in	IN
cord-015021-pol2qm74	5631	7	septic	septic	JJ
cord-015021-pol2qm74	5631	8	patients	patient	NNS
cord-015021-pol2qm74	5631	9	.	.	.
cord-015021-pol2qm74	5632	1	Some	some	DT
cord-015021-pol2qm74	5632	2	clinical	clinical	JJ
cord-015021-pol2qm74	5632	3	and	and	CC
cord-015021-pol2qm74	5632	4	experimental	experimental	JJ
cord-015021-pol2qm74	5632	5	studies	study	NNS
cord-015021-pol2qm74	5632	6	indicate	indicate	VBP
cord-015021-pol2qm74	5632	7	that	that	IN
cord-015021-pol2qm74	5632	8	DIC	DIC	NNP
cord-015021-pol2qm74	5632	9	is	be	VBZ
cord-015021-pol2qm74	5632	10	a	a	DT
cord-015021-pol2qm74	5632	11	pathogenetic	pathogenetic	JJ
cord-015021-pol2qm74	5632	12	factor	factor	NN
cord-015021-pol2qm74	5632	13	for	for	IN
cord-015021-pol2qm74	5632	14	the	the	DT
cord-015021-pol2qm74	5632	15	development	development	NN
cord-015021-pol2qm74	5632	16	of	of	IN
cord-015021-pol2qm74	5632	17	multiple	multiple	JJ
cord-015021-pol2qm74	5632	18	organ	organ	NN
cord-015021-pol2qm74	5632	19	failure	failure	NN
cord-015021-pol2qm74	5632	20	.	.	.
cord-015021-pol2qm74	5633	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	5633	2	and	and	CC
cord-015021-pol2qm74	5633	3	various	various	JJ
cord-015021-pol2qm74	5633	4	mediators	mediator	NNS
cord-015021-pol2qm74	5633	5	(	(	-LRB-
cord-015021-pol2qm74	5633	6	TNF	TNF	NNP
cord-015021-pol2qm74	5633	7	,	,	,
cord-015021-pol2qm74	5633	8	IL	IL	NNP
cord-015021-pol2qm74	5633	9	-	-	:
cord-015021-pol2qm74	5633	10	I	I	NNP
cord-015021-pol2qm74	5633	11	)	)	-RRB-
cord-015021-pol2qm74	5633	12	enhance	enhance	VBP
cord-015021-pol2qm74	5633	13	tissue	tissue	NN
cord-015021-pol2qm74	5633	14	factor	factor	NN
cord-015021-pol2qm74	5633	15	and	and	CC
cord-015021-pol2qm74	5633	16	decrease	decrease	VB
cord-015021-pol2qm74	5633	17	expression	expression	NN
cord-015021-pol2qm74	5633	18	of	of	IN
cord-015021-pol2qm74	5633	19	thrombomodulin	thrombomodulin	NNP
cord-015021-pol2qm74	5633	20	on	on	IN
cord-015021-pol2qm74	5633	21	endothelial	endothelial	JJ
cord-015021-pol2qm74	5633	22	cells	cell	NNS
cord-015021-pol2qm74	5633	23	in	in	IN
cord-015021-pol2qm74	5633	24	vitro	vitro	FW
cord-015021-pol2qm74	5633	25	.	.	.
cord-015021-pol2qm74	5634	1	Also	also	RB
cord-015021-pol2qm74	5634	2	,	,	,
cord-015021-pol2qm74	5634	3	tPA	tpa	NN
cord-015021-pol2qm74	5634	4	activity	activity	NN
cord-015021-pol2qm74	5634	5	is	be	VBZ
cord-015021-pol2qm74	5634	6	suppressed	suppress	VBN
cord-015021-pol2qm74	5634	7	and	and	CC
cord-015021-pol2qm74	5634	8	release	release	NN
cord-015021-pol2qm74	5634	9	of	of	IN
cord-015021-pol2qm74	5634	10	PAI	PAI	NNP
cord-015021-pol2qm74	5634	11	-	-	:
cord-015021-pol2qm74	5634	12	I	-PRON-	PRP
cord-015021-pol2qm74	5634	13	is	be	VBZ
cord-015021-pol2qm74	5634	14	stimulated	stimulate	VBN
cord-015021-pol2qm74	5634	15	.	.	.
cord-015021-pol2qm74	5635	1	In	in	IN
cord-015021-pol2qm74	5635	2	such	such	PDT
cord-015021-pol2qm74	5635	3	a	a	DT
cord-015021-pol2qm74	5635	4	way	way	NN
cord-015021-pol2qm74	5635	5	the	the	DT
cord-015021-pol2qm74	5635	6	endothelial	endothelial	JJ
cord-015021-pol2qm74	5635	7	surface	surface	NN
cord-015021-pol2qm74	5635	8	becomes	become	VBZ
cord-015021-pol2qm74	5635	9	procoagulant	procoagulant	NN
cord-015021-pol2qm74	5635	10	whereas	whereas	IN
cord-015021-pol2qm74	5635	11	fibrinolysis	fibrinolysis	NNP
cord-015021-pol2qm74	5635	12	is	be	VBZ
cord-015021-pol2qm74	5635	13	inhibited	inhibit	VBN
cord-015021-pol2qm74	5635	14	.	.	.
cord-015021-pol2qm74	5636	1	Following	follow	VBG
cord-015021-pol2qm74	5636	2	administration	administration	NN
cord-015021-pol2qm74	5636	3	of	of	IN
cord-015021-pol2qm74	5636	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5636	5	to	to	IN
cord-015021-pol2qm74	5636	6	normal	normal	JJ
cord-015021-pol2qm74	5636	7	volunteers	volunteer	NNS
cord-015021-pol2qm74	5636	8	levels	level	NNS
cord-015021-pol2qm74	5636	9	of	of	IN
cord-015021-pol2qm74	5636	10	prothrombin	prothrombin	NN
cord-015021-pol2qm74	5636	11	fragments	fragment	NNS
cord-015021-pol2qm74	5636	12	(	(	-LRB-
cord-015021-pol2qm74	5636	13	FI+2	FI+2	NNP
cord-015021-pol2qm74	5636	14	)	)	-RRB-
cord-015021-pol2qm74	5636	15	and	and	CC
cord-015021-pol2qm74	5636	16	thrombin	thrombin	NN
cord-015021-pol2qm74	5636	17	-	-	HYPH
cord-015021-pol2qm74	5636	18	antithrombin	antithrombin	NN
cord-015021-pol2qm74	5636	19	(	(	-LRB-
cord-015021-pol2qm74	5636	20	TAT	tat	NN
cord-015021-pol2qm74	5636	21	)	)	-RRB-
cord-015021-pol2qm74	5636	22	complexes	complex	NNS
cord-015021-pol2qm74	5636	23	increase	increase	VBP
cord-015021-pol2qm74	5636	24	,	,	,
cord-015021-pol2qm74	5636	25	indicating	indicate	VBG
cord-015021-pol2qm74	5636	26	thrombin	thrombin	JJ
cord-015021-pol2qm74	5636	27	generation	generation	NN
cord-015021-pol2qm74	5636	28	.	.	.
cord-015021-pol2qm74	5637	1	Also	also	RB
cord-015021-pol2qm74	5637	2	the	the	DT
cord-015021-pol2qm74	5637	3	fibrinolytic	fibrinolytic	JJ
cord-015021-pol2qm74	5637	4	system	system	NN
cord-015021-pol2qm74	5637	5	is	be	VBZ
cord-015021-pol2qm74	5637	6	activated	activate	VBN
cord-015021-pol2qm74	5637	7	as	as	IN
cord-015021-pol2qm74	5637	8	evidenced	evidence	VBN
cord-015021-pol2qm74	5637	9	by	by	IN
cord-015021-pol2qm74	5637	10	a	a	DT
cord-015021-pol2qm74	5637	11	rise	rise	NN
cord-015021-pol2qm74	5637	12	of	of	IN
cord-015021-pol2qm74	5637	13	levels	level	NNS
cord-015021-pol2qm74	5637	14	of	of	IN
cord-015021-pol2qm74	5637	15	tPA	tPA	NNP
cord-015021-pol2qm74	5637	16	and	and	CC
cord-015021-pol2qm74	5637	17	plasmin	plasmin	NNP
cord-015021-pol2qm74	5637	18	-	-	HYPH
cord-015021-pol2qm74	5637	19	antiplasmin	antiplasmin	NNP
cord-015021-pol2qm74	5637	20	(	(	-LRB-
cord-015021-pol2qm74	5637	21	PAP	pap	NN
cord-015021-pol2qm74	5637	22	)	)	-RRB-
cord-015021-pol2qm74	5637	23	complexes	complex	NNS
cord-015021-pol2qm74	5638	1	but	but	CC
cord-015021-pol2qm74	5638	2	this	this	DT
cord-015021-pol2qm74	5638	3	is	be	VBZ
cord-015021-pol2qm74	5638	4	counteracted	counteract	VBN
cord-015021-pol2qm74	5638	5	by	by	IN
cord-015021-pol2qm74	5638	6	a	a	DT
cord-015021-pol2qm74	5638	7	subsequent	subsequent	JJ
cord-015021-pol2qm74	5638	8	release	release	NN
cord-015021-pol2qm74	5638	9	of	of	IN
cord-015021-pol2qm74	5638	10	PAI	PAI	NNP
cord-015021-pol2qm74	5638	11	-	-	HYPH
cord-015021-pol2qm74	5638	12	I.	I.	NNP
cord-015021-pol2qm74	5639	1	In	in	IN
cord-015021-pol2qm74	5639	2	severely	severely	RB
cord-015021-pol2qm74	5639	3	ill	ill	JJ
cord-015021-pol2qm74	5639	4	septic	septic	JJ
cord-015021-pol2qm74	5639	5	patients	patient	NNS
cord-015021-pol2qm74	5639	6	levels	level	NNS
cord-015021-pol2qm74	5639	7	of	of	IN
cord-015021-pol2qm74	5639	8	TAT	tat	NN
cord-015021-pol2qm74	5639	9	complexes	complex	NNS
cord-015021-pol2qm74	5639	10	are	be	VBP
cord-015021-pol2qm74	5639	11	increased	increase	VBN
cord-015021-pol2qm74	5639	12	and	and	CC
cord-015021-pol2qm74	5639	13	concentrations	concentration	NNS
cord-015021-pol2qm74	5639	14	of	of	IN
cord-015021-pol2qm74	5639	15	the	the	DT
cord-015021-pol2qm74	5639	16	natural	natural	JJ
cord-015021-pol2qm74	5639	17	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5639	18	of	of	IN
cord-015021-pol2qm74	5639	19	coagulation	coagulation	NN
cord-015021-pol2qm74	5639	20	(	(	-LRB-
cord-015021-pol2qm74	5639	21	AT	at	IN
cord-015021-pol2qm74	5639	22	III	III	NNP
cord-015021-pol2qm74	5639	23	,	,	,
cord-015021-pol2qm74	5639	24	protein	protein	NN
cord-015021-pol2qm74	5639	25	C	C	NNP
cord-015021-pol2qm74	5639	26	)	)	-RRB-
cord-015021-pol2qm74	5639	27	are	be	VBP
cord-015021-pol2qm74	5639	28	usually	usually	RB
cord-015021-pol2qm74	5639	29	decreased	decrease	VBN
cord-015021-pol2qm74	5639	30	.	.	.
cord-015021-pol2qm74	5640	1	Also	also	RB
cord-015021-pol2qm74	5640	2	,	,	,
cord-015021-pol2qm74	5640	3	tPA	tPA	NNP
cord-015021-pol2qm74	5640	4	levels	level	NNS
cord-015021-pol2qm74	5640	5	snd	snd	NNP
cord-015021-pol2qm74	5640	6	PAP	pap	NN
cord-015021-pol2qm74	5640	7	complexes	complex	NNS
cord-015021-pol2qm74	5640	8	as	as	RB
cord-015021-pol2qm74	5640	9	well	well	RB
cord-015021-pol2qm74	5640	10	as	as	IN
cord-015021-pol2qm74	5640	11	concentrations	concentration	NNS
cord-015021-pol2qm74	5640	12	of	of	IN
cord-015021-pol2qm74	5640	13	PAI	PAI	NNP
cord-015021-pol2qm74	5640	14	-	-	:
cord-015021-pol2qm74	5640	15	I	-PRON-	PRP
cord-015021-pol2qm74	5640	16	are	be	VBP
cord-015021-pol2qm74	5640	17	elevated	elevated	JJ
cord-015021-pol2qm74	5640	18	.	.	.
cord-015021-pol2qm74	5641	1	The	the	DT
cord-015021-pol2qm74	5641	2	severity	severity	NN
cord-015021-pol2qm74	5641	3	of	of	IN
cord-015021-pol2qm74	5641	4	many	many	JJ
cord-015021-pol2qm74	5641	5	of	of	IN
cord-015021-pol2qm74	5641	6	these	these	DT
cord-015021-pol2qm74	5641	7	alterations	alteration	NNS
cord-015021-pol2qm74	5641	8	is	be	VBZ
cord-015021-pol2qm74	5641	9	related	relate	VBN
cord-015021-pol2qm74	5641	10	to	to	IN
cord-015021-pol2qm74	5641	11	mortality	mortality	NN
cord-015021-pol2qm74	5641	12	.	.	.
cord-015021-pol2qm74	5642	1	Thus	thus	RB
cord-015021-pol2qm74	5642	2	,	,	,
cord-015021-pol2qm74	5642	3	both	both	DT
cord-015021-pol2qm74	5642	4	coagulation	coagulation	NN
cord-015021-pol2qm74	5642	5	and	and	CC
cord-015021-pol2qm74	5642	6	fibrinolysis	fibrinolysis	NN
cord-015021-pol2qm74	5642	7	are	be	VBP
cord-015021-pol2qm74	5642	8	activated	activate	VBN
cord-015021-pol2qm74	5642	9	in	in	IN
cord-015021-pol2qm74	5642	10	sepsis	sepsis	NN
cord-015021-pol2qm74	5642	11	,	,	,
cord-015021-pol2qm74	5642	12	but	but	CC
cord-015021-pol2qm74	5642	13	not	not	RB
cord-015021-pol2qm74	5642	14	in	in	IN
cord-015021-pol2qm74	5642	15	a	a	DT
cord-015021-pol2qm74	5642	16	balanced	balanced	JJ
cord-015021-pol2qm74	5642	17	way	way	NN
cord-015021-pol2qm74	5642	18	,	,	,
cord-015021-pol2qm74	5642	19	thereby	thereby	RB
cord-015021-pol2qm74	5642	20	promoting	promote	VBG
cord-015021-pol2qm74	5642	21	coagulation	coagulation	NN
cord-015021-pol2qm74	5642	22	.	.	.
cord-015021-pol2qm74	5643	1	One	one	CD
cord-015021-pol2qm74	5643	2	of	of	IN
cord-015021-pol2qm74	5643	3	the	the	DT
cord-015021-pol2qm74	5643	4	hallmsxk	hallmsxk	NNP
cord-015021-pol2qm74	5643	5	pathological	pathological	JJ
cord-015021-pol2qm74	5643	6	alterations	alteration	NNS
cord-015021-pol2qm74	5643	7	associated	associate	VBN
cord-015021-pol2qm74	5643	8	with	with	IN
cord-015021-pol2qm74	5643	9	sepsis	sepsis	NN
cord-015021-pol2qm74	5643	10	is	be	VBZ
cord-015021-pol2qm74	5643	11	the	the	DT
cord-015021-pol2qm74	5643	12	development	development	NN
cord-015021-pol2qm74	5643	13	of	of	IN
cord-015021-pol2qm74	5643	14	microvascular	microvascular	JJ
cord-015021-pol2qm74	5643	15	thrombosis	thrombosis	NN
cord-015021-pol2qm74	5643	16	,	,	,
cord-015021-pol2qm74	5643	17	an	an	DT
cord-015021-pol2qm74	5643	18	entity	entity	NN
cord-015021-pol2qm74	5644	1	~lmre~	~lmre~	NNP
cord-015021-pol2qm74	5645	1	erizod	erizod	NNP
cord-015021-pol2qm74	5645	2	by	by	IN
cord-015021-pol2qm74	5645	3	microvas	microvas	NNP
cord-015021-pol2qm74	5645	4	~	~	NFP
cord-015021-pol2qm74	5645	5	tlar	tlar	NNP
cord-015021-pol2qm74	5645	6	plugBing	plugbe	VBG
cord-015021-pol2qm74	5645	7	with	with	IN
cord-015021-pol2qm74	5645	8	leukoeyies	leukoeyie	NNS
cord-015021-pol2qm74	5645	9	(	(	-LRB-
cord-015021-pol2qm74	5645	10	predominately	predominately	RB
cord-015021-pol2qm74	5645	11	nentrophils	nentrophils	NNP
cord-015021-pol2qm74	5645	12	)	)	-RRB-
cord-015021-pol2qm74	5645	13	and	and	CC
cord-015021-pol2qm74	5645	14	fibrin	fibrin	NN
cord-015021-pol2qm74	5645	15	deposits	deposit	NNS
cord-015021-pol2qm74	5645	16	.	.	.
cord-015021-pol2qm74	5646	1	PreRanably	preranably	RB
cord-015021-pol2qm74	5646	2	,	,	,
cord-015021-pol2qm74	5646	3	ischemia	ischemia	NN
cord-015021-pol2qm74	5646	4	remlt~	remlt~	NNP
cord-015021-pol2qm74	5647	1	g	g	NNP
cord-015021-pol2qm74	5647	2	fibm	fibm	NNP
cord-015021-pol2qm74	5648	1	ve~-'ttlac	ve~-'ttlac	NNP
cord-015021-pol2qm74	5648	2	ow,.luwion	ow,.luwion	NN
cord-015021-pol2qm74	5648	3	contributes	contribute	VBZ
cord-015021-pol2qm74	5648	4	sisni.ficantly	sisni.ficantly	RB
cord-015021-pol2qm74	5648	5	to	to	TO
cord-015021-pol2qm74	5648	6	end	end	VB
cord-015021-pol2qm74	5648	7	orgen	orgen	NNP
cord-015021-pol2qm74	5648	8	darnaje	darnaje	NNP
cord-015021-pol2qm74	5648	9	and	and	CC
cord-015021-pol2qm74	5648	10	consequent	consequent	NN
cord-015021-pol2qm74	5648	11	dysfatlctlon	dysfatlctlon	NN
cord-015021-pol2qm74	5648	12	.	.	.
cord-015021-pol2qm74	5649	1	P	p	NN
cord-015021-pol2qm74	5649	2	,	,	,
cord-015021-pol2qm74	5649	3	er	er	UH
cord-015021-pol2qm74	5649	4	~	~	NN
cord-015021-pol2qm74	5649	5	t	t	NNP
cord-015021-pol2qm74	5649	6	sRldies	sRldies	NNP
cord-015021-pol2qm74	5649	7	haw	haw	NNP
cord-015021-pol2qm74	5649	8	focused	focus	VBD
cord-015021-pol2qm74	5649	9	pmdominately	pmdominately	RB
cord-015021-pol2qm74	5649	10	on	on	IN
cord-015021-pol2qm74	5649	11	the	the	DT
cord-015021-pol2qm74	5649	12	role	role	NN
cord-015021-pol2qm74	5649	13	of	of	IN
cord-015021-pol2qm74	5649	14	adhesion	adhesion	NN
cord-015021-pol2qm74	5649	15	molecules	molecule	NNS
cord-015021-pol2qm74	5649	16	in	in	IN
cord-015021-pol2qm74	5649	17	the	the	DT
cord-015021-pol2qm74	5649	18	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	5649	19	of	of	IN
cord-015021-pol2qm74	5649	20	neu~	neu~	NNP
cord-015021-pol2qm74	5650	1	ophil	ophil	NNP
cord-015021-pol2qm74	5650	2	sequestration	sequestration	NN
cord-015021-pol2qm74	5650	3	during	during	IN
cord-015021-pol2qm74	5650	4	infection	infection	NN
cord-015021-pol2qm74	5650	5	and	and	CC
cord-015021-pol2qm74	5650	6	s	s	NN
cord-015021-pol2qm74	5650	7	~	~	NFP
cord-015021-pol2qm74	5650	8	sis	sis	NN
cord-015021-pol2qm74	5650	9	.	.	.
cord-015021-pol2qm74	5651	1	This	this	DT
cord-015021-pol2qm74	5651	2	preparation	preparation	NN
cord-015021-pol2qm74	5651	3	will	will	MD
cord-015021-pol2qm74	5651	4	review	review	VB
cord-015021-pol2qm74	5651	5	the	the	DT
cord-015021-pol2qm74	5651	6	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5652	1	underlying	underlie	VBG
cord-015021-pol2qm74	5652	2	intravak-'v.ler	intravak-'v.ler	CD
cord-015021-pol2qm74	5653	1	i	i	PRP
cord-015021-pol2qm74	5653	2	~	~	CD
cord-015021-pol2qm74	5653	3	brin	brin	NNP
cord-015021-pol2qm74	5653	4	deposition	deposition	NNP
cord-015021-pol2qm74	5653	5	and	and	CC
cord-015021-pol2qm74	5653	6	its	-PRON-	PRP$
cord-015021-pol2qm74	5653	7	contribution	contribution	NN
cord-015021-pol2qm74	5653	8	to	to	IN
cord-015021-pol2qm74	5653	9	organ	organ	NN
cord-015021-pol2qm74	5653	10	injury	injury	NN
cord-015021-pol2qm74	5653	11	.	.	.
cord-015021-pol2qm74	5654	1	The	the	DT
cord-015021-pol2qm74	5654	2	normal	normal	JJ
cord-015021-pol2qm74	5654	3	endothelial	endothelial	JJ
cord-015021-pol2qm74	5654	4	cell	cell	NN
cord-015021-pol2qm74	5654	5	sure	sure	RB
cord-015021-pol2qm74	5654	6	is	be	VBZ
cord-015021-pol2qm74	5654	7	generally	generally	RB
cord-015021-pol2qm74	5654	8	conddered	conddered	JJ
cord-015021-pol2qm74	5654	9	1o	1o	CD
cord-015021-pol2qm74	5654	10	be	be	VB
cord-015021-pol2qm74	5654	11	anticos	anticos	NNP
cord-015021-pol2qm74	5654	12	~	~	NFP
cord-015021-pol2qm74	5654	13	am	am	NN
cord-015021-pol2qm74	5654	14	.	.	.
cord-015021-pol2qm74	5655	1	This	this	DT
cord-015021-pol2qm74	5655	2	state	state	NN
cord-015021-pol2qm74	5655	3	is	be	VBZ
cord-015021-pol2qm74	5655	4	maintained	maintain	VBN
cord-015021-pol2qm74	5655	5	by	by	IN
cord-015021-pol2qm74	5655	6	two	two	CD
cord-015021-pol2qm74	5655	7	major	major	JJ
cord-015021-pol2qm74	5655	8	anticoag	anticoag	NN
cord-015021-pol2qm74	5655	9	~	~	NFP
cord-015021-pol2qm74	5655	10	lam	lam	NNP
cord-015021-pol2qm74	5655	11	molecules	molecule	NNS
cord-015021-pol2qm74	5655	12	on	on	IN
cord-015021-pol2qm74	5655	13	the	the	DT
cord-015021-pol2qm74	5655	14	cell	cell	NN
cord-015021-pol2qm74	5656	1	so	so	RB
cord-015021-pol2qm74	5656	2	,	,	,
cord-015021-pol2qm74	5656	3	ace	ace	NN
cord-015021-pol2qm74	5656	4	:	:	:
cord-015021-pol2qm74	5656	5	hepax'an	hepax'an	NNP
cord-015021-pol2qm74	5656	6	su	su	NNP
cord-015021-pol2qm74	5656	7	,	,	,
cord-015021-pol2qm74	5656	8	lfale	lfale	NNP
cord-015021-pol2qm74	5656	9	and	and	CC
cord-015021-pol2qm74	5656	10	thmmbomodulin	thmmbomodulin	NNP
cord-015021-pol2qm74	5656	11	.	.	.
cord-015021-pol2qm74	5657	1	Studies	study	NNS
cord-015021-pol2qm74	5657	2	performed	perform	VBN
cord-015021-pol2qm74	5657	3	over	over	IN
cord-015021-pol2qm74	5657	4	the	the	DT
cord-015021-pol2qm74	5657	5	past	past	JJ
cord-015021-pol2qm74	5657	6	decade	decade	NN
cord-015021-pol2qm74	5657	7	have	have	VBP
cord-015021-pol2qm74	5657	8	do	do	VBP
cord-015021-pol2qm74	5657	9	~	~	CD
cord-015021-pol2qm74	5657	10	mentod	mentod	NNP
cord-015021-pol2qm74	5657	11	a	a	DT
cord-015021-pol2qm74	5657	12	general	general	JJ
cord-015021-pol2qm74	5657	13	shii~	shii~	NNP
cord-015021-pol2qm74	5657	14	towards	towards	IN
cord-015021-pol2qm74	5657	15	a	a	DT
cord-015021-pol2qm74	5657	16	procoa	procoa	NNS
cord-015021-pol2qm74	5657	17	~	~	NFP
cord-015021-pol2qm74	5657	18	qtlant	qtlant	NNP
cord-015021-pol2qm74	5657	19	staw	staw	NNP
cord-015021-pol2qm74	5657	20	during	during	IN
cord-015021-pol2qm74	5657	21	gram	gram	NN
cord-015021-pol2qm74	5657	22	negative	negative	JJ
cord-015021-pol2qm74	5657	23	hffeodon	hffeodon	NN
cord-015021-pol2qm74	5657	24	,	,	,
cord-015021-pol2qm74	5657	25	aft	aft	JJ
cord-015021-pol2qm74	5657	26	e~|	e~|	NNP
cord-015021-pol2qm74	5657	27	mediated	mediate	VBN
cord-015021-pol2qm74	5657	28	mainly	mainly	RB
cord-015021-pol2qm74	5657	29	by	by	IN
cord-015021-pol2qm74	5657	30	changes	change	NNS
cord-015021-pol2qm74	5657	31	in	in	IN
cord-015021-pol2qm74	5657	32	the	the	DT
cord-015021-pol2qm74	5657	33	endothalial	endothalial	JJ
cord-015021-pol2qm74	5657	34	cell	cell	NN
cord-015021-pol2qm74	5657	35	surface	surface	NN
cord-015021-pol2qm74	5657	36	.	.	.
cord-015021-pol2qm74	5658	1	antt	antt	NNP
cord-015021-pol2qm74	5658	2	-	-	HYPH
cord-015021-pol2qm74	5658	3	TF	TF	NNP
cord-015021-pol2qm74	5658	4	antibodies	antibody	NNS
cord-015021-pol2qm74	5658	5	have	have	VBP
cord-015021-pol2qm74	5658	6	been	be	VBN
cord-015021-pol2qm74	5658	7	shown	show	VBN
cord-015021-pol2qm74	5658	8	to	to	TO
cord-015021-pol2qm74	5658	9	be	be	VB
cord-015021-pol2qm74	5658	10	pro	pro	JJ
cord-015021-pol2qm74	5658	11	~	~	XX
cord-015021-pol2qm74	5658	12	ective	ective	JJ
cord-015021-pol2qm74	5658	13	during	during	IN
cord-015021-pol2qm74	5658	14	l~'ml	l~'ml	NNP
cord-015021-pol2qm74	5658	15	endotexemia	endotexemia	NN
cord-015021-pol2qm74	5658	16	.	.	.
cord-015021-pol2qm74	5659	1	In	in	IN
cord-015021-pol2qm74	5659	2	summary	summary	NN
cord-015021-pol2qm74	5659	3	,	,	,
cord-015021-pol2qm74	5659	4	~erova~'~ler	~erova~'~ler	ADD
cord-015021-pol2qm74	5659	5	fibrin	fibrin	NN
cord-015021-pol2qm74	5659	6	deposition	deposition	NN
cord-015021-pol2qm74	5659	7	,	,	,
cord-015021-pol2qm74	5659	8	in	in	IN
cord-015021-pol2qm74	5659	9	~rt	~rt	NNP
cord-015021-pol2qm74	5659	10	mediated	mediate	VBN
cord-015021-pol2qm74	5659	11	by	by	IN
cord-015021-pol2qm74	5659	12	~rcgulation	~rcgulation	NNP
cord-015021-pol2qm74	5659	13	of	of	IN
cord-015021-pol2qm74	5659	14	cellular	cellular	JJ
cord-015021-pol2qm74	5659	15	TF	TF	NNP
cord-015021-pol2qm74	5659	16	,	,	,
cord-015021-pol2qm74	5659	17	is	be	VBZ
cord-015021-pol2qm74	5659	18	a	a	DT
cord-015021-pol2qm74	5659	19	consistemt	consistemt	NNP
cord-015021-pol2qm74	5659	20	patholo	patholo	NNP
cord-015021-pol2qm74	5659	21	~	~	NFP
cord-015021-pol2qm74	5659	22	cal	cal	XX
cord-015021-pol2qm74	5659	23	flndin~	flndin~	NNP
cord-015021-pol2qm74	5659	24	during	during	IN
cord-015021-pol2qm74	5659	25	sepsis	sepsis	NN
cord-015021-pol2qm74	5659	26	and	and	CC
cord-015021-pol2qm74	5659	27	contributes	contribute	VBZ
cord-015021-pol2qm74	5659	28	to	to	IN
cord-015021-pol2qm74	5659	29	organ	organ	NN
cord-015021-pol2qm74	5659	30	injury	injury	NN
cord-015021-pol2qm74	5659	31	.	.	.
cord-015021-pol2qm74	5660	1	Strategies	strategy	NNS
cord-015021-pol2qm74	5660	2	designed	design	VBN
cord-015021-pol2qm74	5660	3	to	to	TO
cord-015021-pol2qm74	5660	4	abrogate	abrogate	VB
cord-015021-pol2qm74	5660	5	this	this	DT
cord-015021-pol2qm74	5660	6	event	event	NN
cord-015021-pol2qm74	5660	7	may	may	MD
cord-015021-pol2qm74	5660	8	n	n	VB
cord-015021-pol2qm74	5660	9	~	~	NFP
cord-015021-pol2qm74	5660	10	nimJze	nimJze	NNP
cord-015021-pol2qm74	5660	11	the	the	DT
cord-015021-pol2qm74	5660	12	magnitude	magnitude	NN
cord-015021-pol2qm74	5660	13	of	of	IN
cord-015021-pol2qm74	5660	14	erg~	erg~	CD
cord-015021-pol2qm74	5660	15	dysftm	dysftm	NNP
cord-015021-pol2qm74	5660	16	~	~	NFP
cord-015021-pol2qm74	5660	17	on	on	IN
cord-015021-pol2qm74	5660	18	.	.	.
cord-015021-pol2qm74	5661	1	N	N	NNP
cord-015021-pol2qm74	5661	2	,	,	,
cord-015021-pol2qm74	5661	3	V	V	NNP
cord-015021-pol2qm74	5661	4	,	,	,
cord-015021-pol2qm74	5661	5	Christou	Christou	NNP
cord-015021-pol2qm74	5661	6	MD	MD	NNP
cord-015021-pol2qm74	5661	7	PhD	phd	NN
cord-015021-pol2qm74	5661	8	,	,	,
cord-015021-pol2qm74	5661	9	Department	Department	NNP
cord-015021-pol2qm74	5661	10	of	of	IN
cord-015021-pol2qm74	5661	11	Surgery	Surgery	NNP
cord-015021-pol2qm74	5661	12	,	,	,
cord-015021-pol2qm74	5661	13	MeGill	MeGill	NNP
cord-015021-pol2qm74	5661	14	University	University	NNP
cord-015021-pol2qm74	5661	15	,	,	,
cord-015021-pol2qm74	5661	16	Montreal	Montreal	NNP
cord-015021-pol2qm74	5661	17	,	,	,
cord-015021-pol2qm74	5661	18	Quebec	Quebec	NNP
cord-015021-pol2qm74	5661	19	,	,	,
cord-015021-pol2qm74	5661	20	CANADA	CANADA	NNP
cord-015021-pol2qm74	5661	21	Interactions	Interactions	NNPS
cord-015021-pol2qm74	5661	22	between	between	IN
cord-015021-pol2qm74	5661	23	Immune	Immune	NNP
cord-015021-pol2qm74	5661	24	calls	call	NNS
cord-015021-pol2qm74	5661	25	and	and	CC
cord-015021-pol2qm74	5661	26	the	the	DT
cord-015021-pol2qm74	5661	27	endothelium	endothelium	NN
cord-015021-pol2qm74	5661	28	vie	vie	IN
cord-015021-pol2qm74	5661	29	adhesion	adhesion	NN
cord-015021-pol2qm74	5661	30	molecules	molecule	NNS
cord-015021-pol2qm74	5661	31	serve	serve	VBP
cord-015021-pol2qm74	5661	32	to	to	TO
cord-015021-pol2qm74	5661	33	modulate	modulate	VB
cord-015021-pol2qm74	5661	34	immune	immune	JJ
cord-015021-pol2qm74	5661	35	cell	cell	NN
cord-015021-pol2qm74	5661	36	traffic	traffic	NN
cord-015021-pol2qm74	5661	37	between	between	IN
cord-015021-pol2qm74	5661	38	the	the	DT
cord-015021-pol2qm74	5661	39	blood	blood	NN
cord-015021-pol2qm74	5661	40	strum	strum	NN
cord-015021-pol2qm74	5661	41	and	and	CC
cord-015021-pol2qm74	5661	42	the	the	DT
cord-015021-pol2qm74	5661	43	extrmvascular	extrmvascular	JJ
cord-015021-pol2qm74	5661	44	space	space	NN
cord-015021-pol2qm74	5661	45	,	,	,
cord-015021-pol2qm74	5661	46	These	these	DT
cord-015021-pol2qm74	5661	47	families	family	NNS
cord-015021-pol2qm74	5661	48	of	of	IN
cord-015021-pol2qm74	5661	49	molecules	molecule	NNS
cord-015021-pol2qm74	5661	50	acting	act	VBG
cord-015021-pol2qm74	5661	51	in	in	IN
cord-015021-pol2qm74	5661	52	a	a	DT
cord-015021-pol2qm74	5661	53	cascade	cascade	NN
cord-015021-pol2qm74	5661	54	and	and	CC
cord-015021-pol2qm74	5661	55	closely	closely	RB
cord-015021-pol2qm74	5661	56	integrated	integrate	VBN
cord-015021-pol2qm74	5661	57	with	with	IN
cord-015021-pol2qm74	5661	58	the	the	DT
cord-015021-pol2qm74	5661	59	oytoklna	oytoklna	NNP
cord-015021-pol2qm74	5661	60	network	network	NN
cord-015021-pol2qm74	5661	61	,	,	,
cord-015021-pol2qm74	5661	62	blood	blood	NN
cord-015021-pol2qm74	5661	63	coagulation	coagulation	NN
cord-015021-pol2qm74	5661	64	and	and	CC
cord-015021-pol2qm74	5661	65	the	the	DT
cord-015021-pol2qm74	5661	66	complement	complement	NN
cord-015021-pol2qm74	5661	67	system	system	NN
cord-015021-pol2qm74	5661	68	,	,	,
cord-015021-pol2qm74	5661	69	are	be	VBP
cord-015021-pol2qm74	5661	70	responsible	responsible	JJ
cord-015021-pol2qm74	5661	71	for	for	IN
cord-015021-pol2qm74	5661	72	the	the	DT
cord-015021-pol2qm74	5661	73	homing	homing	NN
cord-015021-pol2qm74	5661	74	of	of	IN
cord-015021-pol2qm74	5661	75	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	5661	76	to	to	IN
cord-015021-pol2qm74	5661	77	areas	area	NNS
cord-015021-pol2qm74	5661	78	of	of	IN
cord-015021-pol2qm74	5661	79	inflammation	inflammation	NN
cord-015021-pol2qm74	5661	80	and	and	CC
cord-015021-pol2qm74	5661	81	the	the	DT
cord-015021-pol2qm74	5661	82	realrculatlon	realrculatlon	NN
cord-015021-pol2qm74	5661	83	of	of	IN
cord-015021-pol2qm74	5661	84	tymphocytes	tymphocyte	NNS
cord-015021-pol2qm74	5661	85	.	.	.
cord-015021-pol2qm74	5662	1	There	there	EX
cord-015021-pol2qm74	5662	2	are	be	VBP
cord-015021-pol2qm74	5662	3	three	three	CD
cord-015021-pol2qm74	5662	4	types	type	NNS
cord-015021-pol2qm74	5662	5	of	of	IN
cord-015021-pol2qm74	5662	6	immune	immune	JJ
cord-015021-pol2qm74	5662	7	ceils	ceil	NNS
cord-015021-pol2qm74	5662	8	that	that	WDT
cord-015021-pol2qm74	5662	9	must	must	MD
cord-015021-pol2qm74	5662	10	exit	exit	VB
cord-015021-pol2qm74	5662	11	the	the	DT
cord-015021-pol2qm74	5662	12	blood	blood	NN
cord-015021-pol2qm74	5662	13	stream	stream	NN
cord-015021-pol2qm74	5662	14	into	into	IN
cord-015021-pol2qm74	5662	15	the	the	DT
cord-015021-pol2qm74	5662	16	extravascular	extravascular	JJ
cord-015021-pol2qm74	5662	17	space	space	NN
cord-015021-pol2qm74	5662	18	:	:	:
cord-015021-pol2qm74	5662	19	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	5662	20	;	;	:
cord-015021-pol2qm74	5662	21	polymorphonuclear	polymorphonuclear	NNP
cord-015021-pol2qm74	5662	22	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	5662	23	;	;	:
cord-015021-pol2qm74	5662	24	and	and	CC
cord-015021-pol2qm74	5662	25	non	non	JJ
cord-015021-pol2qm74	5662	26	-	-	JJ
cord-015021-pol2qm74	5662	27	lymphocyta	lymphocyta	JJ
cord-015021-pol2qm74	5662	28	mononuclaar	mononuclaar	NN
cord-015021-pol2qm74	5662	29	cells	cell	NNS
cord-015021-pol2qm74	5662	30	(	(	-LRB-
cord-015021-pol2qm74	5662	31	monooytes	monooytes	NNP
cord-015021-pol2qm74	5662	32	,	,	,
cord-015021-pol2qm74	5662	33	basophlls	basophlls	NNP
cord-015021-pol2qm74	5662	34	,	,	,
cord-015021-pol2qm74	5662	35	aoslncphils	aoslncphils	NNP
cord-015021-pol2qm74	5662	36	)	)	-RRB-
cord-015021-pol2qm74	5662	37	.	.	.
cord-015021-pol2qm74	5663	1	B	b	NN
cord-015021-pol2qm74	5663	2	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	5663	3	exit	exit	VBP
cord-015021-pol2qm74	5663	4	the	the	DT
cord-015021-pol2qm74	5663	5	blood	blood	NN
cord-015021-pol2qm74	5663	6	stream	stream	NN
cord-015021-pol2qm74	5663	7	and	and	CC
cord-015021-pol2qm74	5663	8	recircu}ate	recircu}ate	VB
cord-015021-pol2qm74	5663	9	mostly	mostly	RB
cord-015021-pol2qm74	5663	10	via	via	IN
cord-015021-pol2qm74	5663	11	the	the	DT
cord-015021-pol2qm74	5663	12	high	high	JJ
cord-015021-pol2qm74	5663	13	endothelial	endothelial	JJ
cord-015021-pol2qm74	5663	14	venule	venule	NN
cord-015021-pol2qm74	5663	15	(	(	-LRB-
cord-015021-pol2qm74	5663	16	HEV	HEV	NNP
cord-015021-pol2qm74	5663	17	)	)	-RRB-
cord-015021-pol2qm74	5663	18	in	in	IN
cord-015021-pol2qm74	5663	19	lymphatic	lymphatic	JJ
cord-015021-pol2qm74	5663	20	tissue	tissue	NN
cord-015021-pol2qm74	5663	21	,	,	,
cord-015021-pol2qm74	5663	22	Rarely	rarely	RB
cord-015021-pol2qm74	5663	23	,	,	,
cord-015021-pol2qm74	5663	24	in	in	IN
cord-015021-pol2qm74	5663	25	chronic	chronic	JJ
cord-015021-pol2qm74	5663	26	}	}	-RRB-
cord-015021-pol2qm74	5663	27	nfectlon=	nfectlon=	NN
cord-015021-pol2qm74	5663	28	,	,	,
cord-015021-pol2qm74	5663	29	they	-PRON-	PRP
cord-015021-pol2qm74	5663	30	may	may	MD
cord-015021-pol2qm74	5663	31	recirQulate	recirqulate	VB
cord-015021-pol2qm74	5664	1	vie	vie	NNP
cord-015021-pol2qm74	5664	2	HEV	hev	VB
cord-015021-pol2qm74	5664	3	in	in	IN
cord-015021-pol2qm74	5664	4	non	non	JJ
cord-015021-pol2qm74	5664	5	-	-	JJ
cord-015021-pol2qm74	5664	6	lymphoi	lymphoi	JJ
cord-015021-pol2qm74	5664	7	:	:	:
cord-015021-pol2qm74	5664	8	t	t	NN
cord-015021-pol2qm74	5664	9	tissue	tissue	NN
cord-015021-pol2qm74	5664	10	.	.	.
cord-015021-pol2qm74	5665	1	T	t	NN
cord-015021-pol2qm74	5665	2	-	-	HYPH
cord-015021-pol2qm74	5665	3	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	5665	4	recircutation	recircutation	NN
cord-015021-pol2qm74	5665	5	on	on	IN
cord-015021-pol2qm74	5665	6	the	the	DT
cord-015021-pol2qm74	5665	7	other	other	JJ
cord-015021-pol2qm74	5665	8	hand	hand	NN
cord-015021-pol2qm74	5665	9	can	can	MD
cord-015021-pol2qm74	5665	10	occur	occur	VB
cord-015021-pol2qm74	5665	11	via	via	IN
cord-015021-pol2qm74	5665	12	HEV	HEV	NNP
cord-015021-pol2qm74	5665	13	in	in	IN
cord-015021-pol2qm74	5665	14	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	5665	15	tissue	tissue	NN
cord-015021-pol2qm74	5665	16	,	,	,
cord-015021-pol2qm74	5665	17	as	as	RB
cord-015021-pol2qm74	5665	18	well	well	RB
cord-015021-pol2qm74	5665	19	as	as	IN
cord-015021-pol2qm74	5665	20	,	,	,
cord-015021-pol2qm74	5665	21	the	the	DT
cord-015021-pol2qm74	5665	22	endothalium	endothalium	NN
cord-015021-pol2qm74	5665	23	of	of	IN
cord-015021-pol2qm74	5665	24	the	the	DT
cord-015021-pol2qm74	5665	25	skin	skin	NN
cord-015021-pol2qm74	5665	26	,	,	,
cord-015021-pol2qm74	5665	27	returning	return	VBG
cord-015021-pol2qm74	5665	28	to	to	IN
cord-015021-pol2qm74	5665	29	peripheral	peripheral	JJ
cord-015021-pol2qm74	5665	30	lymph	lymph	NN
cord-015021-pol2qm74	5665	31	nodes	node	NNS
cord-015021-pol2qm74	5665	32	via	via	IN
cord-015021-pol2qm74	5665	33	the	the	DT
cord-015021-pol2qm74	5665	34	lymphatic	lymphatic	JJ
cord-015021-pol2qm74	5665	35	channels	channel	NNS
cord-015021-pol2qm74	5665	36	.	.	.
cord-015021-pol2qm74	5666	1	Lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	5666	2	recirculation	recirculation	NN
cord-015021-pol2qm74	5666	3	is	be	VBZ
cord-015021-pol2qm74	5666	4	the	the	DT
cord-015021-pol2qm74	5666	5	mechanism	mechanism	NN
cord-015021-pol2qm74	5666	6	which	which	WDT
cord-015021-pol2qm74	5666	7	allows	allow	VBZ
cord-015021-pol2qm74	5666	8	¢ontaot	¢ontaot	VBN
cord-015021-pol2qm74	5666	9	between	between	IN
cord-015021-pol2qm74	5666	10	the	the	DT
cord-015021-pol2qm74	5666	11	immune	immune	JJ
cord-015021-pol2qm74	5666	12	repertoire	repertoire	NN
cord-015021-pol2qm74	5666	13	and	and	CC
cord-015021-pol2qm74	5666	14	pathogens	pathogen	NNS
cord-015021-pol2qm74	5666	15	,	,	,
cord-015021-pol2qm74	5666	16	and	and	CC
cord-015021-pol2qm74	5666	17	homing	homing	NN
cord-015021-pol2qm74	5666	18	delivers	deliver	VBZ
cord-015021-pol2qm74	5666	19	these	these	DT
cord-015021-pol2qm74	5666	20	cells	cell	NNS
cord-015021-pol2qm74	5666	21	to	to	IN
cord-015021-pol2qm74	5666	22	the	the	DT
cord-015021-pol2qm74	5666	23	appropriate	appropriate	JJ
cord-015021-pol2qm74	5666	24	environment	environment	NN
cord-015021-pol2qm74	5666	25	for	for	IN
cord-015021-pol2qm74	5666	26	activation	activation	NN
cord-015021-pol2qm74	5666	27	and	and	CC
cord-015021-pol2qm74	5666	28	for	for	IN
cord-015021-pol2qm74	5666	29	effeotor	effeotor	NN
cord-015021-pol2qm74	5666	30	function	function	NN
cord-015021-pol2qm74	5666	31	,	,	,
cord-015021-pol2qm74	5666	32	PMNs	pmn	NNS
cord-015021-pol2qm74	5666	33	exit	exit	NN
cord-015021-pol2qm74	5666	34	the	the	DT
cord-015021-pol2qm74	5666	35	blood	blood	NN
cord-015021-pol2qm74	5666	36	stream	stream	NN
cord-015021-pol2qm74	5666	37	through	through	IN
cord-015021-pol2qm74	5666	38	endotbelium	endotbelium	NN
cord-015021-pol2qm74	5666	39	in	in	IN
cord-015021-pol2qm74	5666	40	close	close	JJ
cord-015021-pol2qm74	5666	41	proximity	proximity	NN
cord-015021-pol2qm74	5666	42	to	to	IN
cord-015021-pol2qm74	5666	43	the	the	DT
cord-015021-pol2qm74	5666	44	site	site	NN
cord-015021-pol2qm74	5666	45	of	of	IN
cord-015021-pol2qm74	5666	46	inflammation	inflammation	NN
cord-015021-pol2qm74	5666	47	after	after	IN
cord-015021-pol2qm74	5666	48	appropriate	appropriate	JJ
cord-015021-pol2qm74	5666	49	endothelial	endothelial	JJ
cord-015021-pol2qm74	5666	50	membrane	membrane	NN
cord-015021-pol2qm74	5666	51	receptor	receptor	NN
cord-015021-pol2qm74	5666	52	expression	expression	NN
cord-015021-pol2qm74	5666	53	.	.	.
cord-015021-pol2qm74	5667	1	They	-PRON-	PRP
cord-015021-pol2qm74	5667	2	must	must	MD
cord-015021-pol2qm74	5667	3	reach	reach	VB
cord-015021-pol2qm74	5667	4	the	the	DT
cord-015021-pol2qm74	5667	5	site	site	NN
cord-015021-pol2qm74	5667	6	of	of	IN
cord-015021-pol2qm74	5667	7	pathogen	pathogen	NN
cord-015021-pol2qm74	5667	8	tnveslon	tnveslon	NN
cord-015021-pol2qm74	5667	9	quickly	quickly	RB
cord-015021-pol2qm74	5667	10	in	in	IN
cord-015021-pol2qm74	5667	11	order	order	NN
cord-015021-pol2qm74	5667	12	to	to	TO
cord-015021-pol2qm74	5667	13	be	be	VB
cord-015021-pol2qm74	5667	14	effective	effective	JJ
cord-015021-pol2qm74	5667	15	.	.	.
cord-015021-pol2qm74	5668	1	Their	-PRON-	PRP$
cord-015021-pol2qm74	5668	2	exudation	exudation	NN
cord-015021-pol2qm74	5668	3	to	to	IN
cord-015021-pol2qm74	5668	4	the	the	DT
cord-015021-pol2qm74	5668	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5668	6	site	site	NN
cord-015021-pol2qm74	5668	7	can	can	MD
cord-015021-pol2qm74	5668	8	be	be	VB
cord-015021-pol2qm74	5668	9	modulated	modulate	VBN
cord-015021-pol2qm74	5668	10	by	by	IN
cord-015021-pol2qm74	5668	11	their	-PRON-	PRP$
cord-015021-pol2qm74	5668	12	intravascular	intravascular	JJ
cord-015021-pol2qm74	5668	13	pdmlng	pdmlng	NN
cord-015021-pol2qm74	5668	14	,	,	,
cord-015021-pol2qm74	5668	15	which	which	WDT
cord-015021-pol2qm74	5668	16	results	result	VBZ
cord-015021-pol2qm74	5668	17	from	from	IN
cord-015021-pol2qm74	5668	18	appropriate	appropriate	JJ
cord-015021-pol2qm74	5668	19	receptor	receptor	NN
cord-015021-pol2qm74	5668	20	expression	expression	NN
cord-015021-pol2qm74	5668	21	.	.	.
cord-015021-pol2qm74	5669	1	Because	because	IN
cord-015021-pol2qm74	5669	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5669	3	leak	leak	NN
cord-015021-pol2qm74	5669	4	from	from	IN
cord-015021-pol2qm74	5669	5	the	the	DT
cord-015021-pol2qm74	5669	6	gut	gut	NN
cord-015021-pol2qm74	5669	7	has	have	VBZ
cord-015021-pol2qm74	5669	8	been	be	VBN
cord-015021-pol2qm74	5669	9	postulated	postulate	VBN
cord-015021-pol2qm74	5669	10	as	as	IN
cord-015021-pol2qm74	5669	11	an	an	DT
cord-015021-pol2qm74	5669	12	important	important	JJ
cord-015021-pol2qm74	5669	13	trigger	trigger	NN
cord-015021-pol2qm74	5669	14	mechanism	mechanism	NN
cord-015021-pol2qm74	5669	15	for	for	IN
cord-015021-pol2qm74	5669	16	the	the	DT
cord-015021-pol2qm74	5669	17	systemic	systemic	JJ
cord-015021-pol2qm74	5669	18	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5669	19	response	response	NN
cord-015021-pol2qm74	5669	20	syndrome	syndrome	NN
cord-015021-pol2qm74	5669	21	seen	see	VBN
cord-015021-pol2qm74	5669	22	after	after	IN
cord-015021-pol2qm74	5669	23	serious	serious	JJ
cord-015021-pol2qm74	5669	24	injury	injury	NN
cord-015021-pol2qm74	5669	25	,	,	,
cord-015021-pol2qm74	5669	26	the	the	DT
cord-015021-pol2qm74	5669	27	immunologic	immunologic	JJ
cord-015021-pol2qm74	5669	28	and	and	CC
cord-015021-pol2qm74	5669	29	metabolic	metabolic	JJ
cord-015021-pol2qm74	5669	30	effects	effect	NNS
cord-015021-pol2qm74	5669	31	of	of	IN
cord-015021-pol2qm74	5669	32	bacterial	bacterial	JJ
cord-015021-pol2qm74	5669	33	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5669	34	infusion	infusion	NN
cord-015021-pol2qm74	5669	35	into	into	IN
cord-015021-pol2qm74	5669	36	normal	normal	JJ
cord-015021-pol2qm74	5669	37	volunteers	volunteer	NNS
cord-015021-pol2qm74	5669	38	can	can	MD
cord-015021-pol2qm74	5669	39	be	be	VB
cord-015021-pol2qm74	5669	40	expected	expect	VBN
cord-015021-pol2qm74	5669	41	to	to	TO
cord-015021-pol2qm74	5669	42	shed	shed	VB
cord-015021-pol2qm74	5669	43	considerable	considerable	JJ
cord-015021-pol2qm74	5669	44	light	light	NN
cord-015021-pol2qm74	5669	45	on	on	IN
cord-015021-pol2qm74	5669	46	the	the	DT
cord-015021-pol2qm74	5669	47	validity	validity	NN
cord-015021-pol2qm74	5669	48	of	of	IN
cord-015021-pol2qm74	5669	49	this	this	DT
cord-015021-pol2qm74	5669	50	hypothesis	hypothesis	NN
cord-015021-pol2qm74	5669	51	.	.	.
cord-015021-pol2qm74	5670	1	We	-PRON-	PRP
cord-015021-pol2qm74	5670	2	and	and	CC
cord-015021-pol2qm74	5670	3	ethers	ether	NNS
cord-015021-pol2qm74	5670	4	have	have	VBP
cord-015021-pol2qm74	5670	5	used	use	VBN
cord-015021-pol2qm74	5670	6	tbis	tbis	NN
cord-015021-pol2qm74	5670	7	model	model	NN
cord-015021-pol2qm74	5670	8	to	to	TO
cord-015021-pol2qm74	5670	9	show	show	VB
cord-015021-pol2qm74	5670	10	that	that	IN
cord-015021-pol2qm74	5670	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5670	12	causes	cause	VBZ
cord-015021-pol2qm74	5670	13	a	a	DT
cord-015021-pol2qm74	5670	14	temporary	temporary	JJ
cord-015021-pol2qm74	5670	15	paralysis	paralysis	NN
cord-015021-pol2qm74	5670	16	in	in	IN
cord-015021-pol2qm74	5670	17	the	the	DT
cord-015021-pol2qm74	5670	18	ability	ability	NN
cord-015021-pol2qm74	5670	19	of	of	IN
cord-015021-pol2qm74	5670	20	circulating	circulate	VBG
cord-015021-pol2qm74	5670	21	monocytes	monocyte	NNS
cord-015021-pol2qm74	5670	22	to	to	TO
cord-015021-pol2qm74	5670	23	prudce	prudce	VB
cord-015021-pol2qm74	5670	24	the	the	DT
cord-015021-pol2qm74	5670	25	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	5670	26	cytokines	cytokine	NNS
cord-015021-pol2qm74	5671	1	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	5671	2	-	-	HYPH
cord-015021-pol2qm74	5671	3	i	i	NNP
cord-015021-pol2qm74	5671	4	(	(	-LRB-
cord-015021-pol2qm74	5671	5	IL	IL	NNP
cord-015021-pol2qm74	5671	6	-	-	HYPH
cord-015021-pol2qm74	5671	7	I	I	NNP
cord-015021-pol2qm74	5671	8	)	)	-RRB-
cord-015021-pol2qm74	5671	9	and	and	CC
cord-015021-pol2qm74	5671	10	TNF	TNF	NNP
cord-015021-pol2qm74	5671	11	-	-	HYPH
cord-015021-pol2qm74	5671	12	a	a	NNP
cord-015021-pol2qm74	5671	13	.	.	.
cord-015021-pol2qm74	5672	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	5672	2	,	,	,
cord-015021-pol2qm74	5672	3	however	however	RB
cord-015021-pol2qm74	5672	4	,	,	,
cord-015021-pol2qm74	5672	5	causes	cause	VBZ
cord-015021-pol2qm74	5672	6	increased	increase	VBN
cord-015021-pol2qm74	5672	7	production	production	NN
cord-015021-pol2qm74	5672	8	of	of	IN
cord-015021-pol2qm74	5672	9	PGE2	PGE2	NNP
cord-015021-pol2qm74	5672	10	by	by	IN
cord-015021-pol2qm74	5672	11	the	the	DT
cord-015021-pol2qm74	5672	12	same	same	JJ
cord-015021-pol2qm74	5672	13	cell	cell	NN
cord-015021-pol2qm74	5672	14	population	population	NN
cord-015021-pol2qm74	5672	15	.	.	.
cord-015021-pol2qm74	5673	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	5673	2	infusion	infusion	NN
cord-015021-pol2qm74	5673	3	causes	cause	VBZ
cord-015021-pol2qm74	5673	4	significant	significant	JJ
cord-015021-pol2qm74	5673	5	suppression	suppression	NN
cord-015021-pol2qm74	5673	6	of	of	IN
cord-015021-pol2qm74	5673	7	circulating	circulate	VBG
cord-015021-pol2qm74	5673	8	T	t	NN
cord-015021-pol2qm74	5673	9	-	-	HYPH
cord-015021-pol2qm74	5673	10	cell	cell	NN
cord-015021-pol2qm74	5673	11	numbers	number	NNS
cord-015021-pol2qm74	5673	12	and	and	CC
cord-015021-pol2qm74	5673	13	a	a	DT
cord-015021-pol2qm74	5673	14	profound	profound	JJ
cord-015021-pol2qm74	5673	15	suppression	suppression	NN
cord-015021-pol2qm74	5673	16	in	in	IN
cord-015021-pol2qm74	5673	17	the	the	DT
cord-015021-pol2qm74	5673	18	ability	ability	NN
cord-015021-pol2qm74	5673	19	of	of	IN
cord-015021-pol2qm74	5673	20	the	the	DT
cord-015021-pol2qm74	5673	21	circulating	circulate	VBG
cord-015021-pol2qm74	5673	22	T	t	NN
cord-015021-pol2qm74	5673	23	-	-	HYPH
cord-015021-pol2qm74	5673	24	cell	cell	NN
cord-015021-pol2qm74	5673	25	population	population	NN
cord-015021-pol2qm74	5673	26	to	to	TO
cord-015021-pol2qm74	5673	27	proliferate	proliferate	VB
cord-015021-pol2qm74	5673	28	and	and	CC
cord-015021-pol2qm74	5673	29	to	to	TO
cord-015021-pol2qm74	5673	30	produce	produce	VB
cord-015021-pol2qm74	5673	31	Interle	Interle	NNP
cord-015021-pol2qm74	5674	1	~in-2	~in-2	NFP
cord-015021-pol2qm74	5674	2	(	(	-LRB-
cord-015021-pol2qm74	5674	3	IL-2	IL-2	NNP
cord-015021-pol2qm74	5674	4	)	)	-RRB-
cord-015021-pol2qm74	5674	5	upon	upon	IN
cord-015021-pol2qm74	5674	6	in	in	FW
cord-015021-pol2qm74	5674	7	vitro	vitro	FW
cord-015021-pol2qm74	5674	8	stimulation	stimulation	NN
cord-015021-pol2qm74	5674	9	.	.	.
cord-015021-pol2qm74	5675	1	After	after	IN
cord-015021-pol2qm74	5675	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5675	3	circulating	circulate	VBG
cord-015021-pol2qm74	5675	4	T	T	NNP
cord-015021-pol2qm74	5675	5	-	-	HYPH
cord-015021-pol2qm74	5675	6	cells	cell	NNS
cord-015021-pol2qm74	5675	7	are	be	VBP
cord-015021-pol2qm74	5675	8	also	also	RB
cord-015021-pol2qm74	5675	9	more	more	RBR
cord-015021-pol2qm74	5675	10	sensitive	sensitive	JJ
cord-015021-pol2qm74	5675	11	to	to	IN
cord-015021-pol2qm74	5675	12	the	the	DT
cord-015021-pol2qm74	5675	13	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	5675	14	action	action	NN
cord-015021-pol2qm74	5675	15	of	of	IN
cord-015021-pol2qm74	5675	16	exogenous	exogenous	JJ
cord-015021-pol2qm74	5675	17	PGE2	PGE2	NNP
cord-015021-pol2qm74	5675	18	.	.	.
cord-015021-pol2qm74	5676	1	Administration	administration	NN
cord-015021-pol2qm74	5676	2	of	of	IN
cord-015021-pol2qm74	5676	3	cyclooxygenase	cyclooxygenase	NN
cord-015021-pol2qm74	5676	4	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5676	5	at	at	IN
cord-015021-pol2qm74	5676	6	the	the	DT
cord-015021-pol2qm74	5676	7	time	time	NN
cord-015021-pol2qm74	5676	8	of	of	IN
cord-015021-pol2qm74	5676	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5676	10	infusion	infusion	NN
cord-015021-pol2qm74	5676	11	largely	largely	RB
cord-015021-pol2qm74	5676	12	abrogates	abrogate	VBZ
cord-015021-pol2qm74	5676	13	the	the	DT
cord-015021-pol2qm74	5676	14	effect	effect	NN
cord-015021-pol2qm74	5676	15	of	of	IN
cord-015021-pol2qm74	5676	16	endetexin	endetexin	NN
cord-015021-pol2qm74	5676	17	on	on	IN
cord-015021-pol2qm74	5676	18	T	T	NNP
cord-015021-pol2qm74	5676	19	-	-	HYPH
cord-015021-pol2qm74	5676	20	Cell	cell	NN
cord-015021-pol2qm74	5676	21	proliferation	proliferation	NN
cord-015021-pol2qm74	5676	22	and	and	CC
cord-015021-pol2qm74	5676	23	IL-2	il-2	NN
cord-015021-pol2qm74	5676	24	production	production	NN
cord-015021-pol2qm74	5676	25	.	.	.
cord-015021-pol2qm74	5677	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	5677	2	infusion	infusion	NN
cord-015021-pol2qm74	5677	3	also	also	RB
cord-015021-pol2qm74	5677	4	causes	cause	VBZ
cord-015021-pol2qm74	5677	5	the	the	DT
cord-015021-pol2qm74	5677	6	release	release	NN
cord-015021-pol2qm74	5677	7	of	of	IN
cord-015021-pol2qm74	5677	8	increased	increase	VBN
cord-015021-pol2qm74	5677	9	levels	level	NNS
cord-015021-pol2qm74	5677	10	of	of	IN
cord-015021-pol2qm74	5677	11	circulating	circulate	VBG
cord-015021-pol2qm74	5677	12	catabolic	catabolic	JJ
cord-015021-pol2qm74	5677	13	hormones	hormone	NNS
cord-015021-pol2qm74	5677	14	including	include	VBG
cord-015021-pol2qm74	5677	15	cortisol	cortisol	NN
cord-015021-pol2qm74	5677	16	.	.	.
cord-015021-pol2qm74	5678	1	Administration	administration	NN
cord-015021-pol2qm74	5678	2	of	of	IN
cord-015021-pol2qm74	5678	3	cortisol	cortisol	NN
cord-015021-pol2qm74	5678	4	alone	alone	RB
cord-015021-pol2qm74	5678	5	or	or	CC
cord-015021-pol2qm74	5678	6	cortisol	cortisol	NN
cord-015021-pol2qm74	5678	7	along	along	RP
cord-015021-pol2qm74	5678	8	with	with	IN
cord-015021-pol2qm74	5678	9	endetowin	endetowin	NNP
cord-015021-pol2qm74	5678	10	to	to	IN
cord-015021-pol2qm74	5678	11	volunteers	volunteer	NNS
cord-015021-pol2qm74	5678	12	has	have	VBZ
cord-015021-pol2qm74	5678	13	allowed	allow	VBN
cord-015021-pol2qm74	5678	14	dissection	dissection	NN
cord-015021-pol2qm74	5678	15	of	of	IN
cord-015021-pol2qm74	5678	16	cortisol	cortisol	NN
cord-015021-pol2qm74	5678	17	effects	effect	NNS
cord-015021-pol2qm74	5678	18	from	from	IN
cord-015021-pol2qm74	5678	19	those	those	DT
cord-015021-pol2qm74	5678	20	of	of	IN
cord-015021-pol2qm74	5678	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5678	22	itself	-PRON-	PRP
cord-015021-pol2qm74	5678	23	.	.	.
cord-015021-pol2qm74	5679	1	Cortisol	cortisol	NN
cord-015021-pol2qm74	5679	2	infusion	infusion	NN
cord-015021-pol2qm74	5679	3	alone	alone	RB
cord-015021-pol2qm74	5679	4	causes	cause	VBZ
cord-015021-pol2qm74	5679	5	a	a	DT
cord-015021-pol2qm74	5679	6	diminution	diminution	NN
cord-015021-pol2qm74	5679	7	in	in	IN
cord-015021-pol2qm74	5679	8	the	the	DT
cord-015021-pol2qm74	5679	9	circulating	circulate	VBG
cord-015021-pol2qm74	5679	10	T	t	NN
cord-015021-pol2qm74	5679	11	-	-	HYPH
cord-015021-pol2qm74	5679	12	cell	cell	NN
cord-015021-pol2qm74	5679	13	population	population	NN
cord-015021-pol2qm74	5679	14	but	but	CC
cord-015021-pol2qm74	5679	15	the	the	DT
cord-015021-pol2qm74	5679	16	remaining	remain	VBG
cord-015021-pol2qm74	5679	17	ceils	ceil	NNS
cord-015021-pol2qm74	5679	18	continue	continue	VBP
cord-015021-pol2qm74	5679	19	to	to	TO
cord-015021-pol2qm74	5679	20	produce	produce	VB
cord-015021-pol2qm74	5679	21	IL-2	il-2	NN
cord-015021-pol2qm74	5680	1	after	after	IN
cord-015021-pol2qm74	5680	2	appropriate	appropriate	JJ
cord-015021-pol2qm74	5680	3	stimulation	stimulation	NN
cord-015021-pol2qm74	5680	4	.	.	.
cord-015021-pol2qm74	5681	1	Cortisol	cortisol	NN
cord-015021-pol2qm74	5681	2	infused	infuse	VBN
cord-015021-pol2qm74	5681	3	along	along	IN
cord-015021-pol2qm74	5681	4	with	with	IN
cord-015021-pol2qm74	5681	5	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5681	6	blocks	block	VBZ
cord-015021-pol2qm74	5681	7	the	the	DT
cord-015021-pol2qm74	5681	8	overshoot	overshoot	NN
cord-015021-pol2qm74	5681	9	in	in	IN
cord-015021-pol2qm74	5681	10	monocyte	monocyte	NNP
cord-015021-pol2qm74	5681	11	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	5681	12	cytokine	cytokine	NN
cord-015021-pol2qm74	5681	13	production	production	NN
cord-015021-pol2qm74	5681	14	seen	see	VBN
cord-015021-pol2qm74	5681	15	24	24	CD
cord-015021-pol2qm74	5681	16	-48	-48	NNP
cord-015021-pol2qm74	5681	17	hours	hour	NNS
cord-015021-pol2qm74	5681	18	after	after	IN
cord-015021-pol2qm74	5681	19	endetoxin	endetoxin	NN
cord-015021-pol2qm74	5681	20	infusion	infusion	NN
cord-015021-pol2qm74	5681	21	.	.	.
cord-015021-pol2qm74	5682	1	At	at	IN
cord-015021-pol2qm74	5682	2	present	present	NN
cord-015021-pol2qm74	5682	3	,	,	,
cord-015021-pol2qm74	5682	4	one	one	PRP
cord-015021-pol2qm74	5682	5	may	may	MD
cord-015021-pol2qm74	5682	6	conclude	conclude	VB
cord-015021-pol2qm74	5682	7	that	that	IN
cord-015021-pol2qm74	5682	8	administration	administration	NN
cord-015021-pol2qm74	5682	9	of	of	IN
cord-015021-pol2qm74	5682	10	sublethal	sublethal	JJ
cord-015021-pol2qm74	5682	11	doses	dose	NNS
cord-015021-pol2qm74	5682	12	of	of	IN
cord-015021-pol2qm74	5682	13	bacterial	bacterial	JJ
cord-015021-pol2qm74	5682	14	endetoxin	endetoxin	NN
cord-015021-pol2qm74	5682	15	to	to	IN
cord-015021-pol2qm74	5682	16	human	human	JJ
cord-015021-pol2qm74	5682	17	volusteers	volusteer	NNS
cord-015021-pol2qm74	5682	18	produces	produce	VBZ
cord-015021-pol2qm74	5682	19	alterations	alteration	NNS
cord-015021-pol2qm74	5682	20	in	in	IN
cord-015021-pol2qm74	5682	21	cytokime	cytokime	NN
cord-015021-pol2qm74	5682	22	production	production	NN
cord-015021-pol2qm74	5682	23	and	and	CC
cord-015021-pol2qm74	5682	24	Tlymphocyte	Tlymphocyte	NNP
cord-015021-pol2qm74	5682	25	activation	activation	NN
cord-015021-pol2qm74	5682	26	which	which	WDT
cord-015021-pol2qm74	5682	27	are	be	VBP
cord-015021-pol2qm74	5682	28	both	both	DT
cord-015021-pol2qm74	5682	29	similar	similar	JJ
cord-015021-pol2qm74	5682	30	and	and	CC
cord-015021-pol2qm74	5682	31	dissimilar	dissimilar	JJ
cord-015021-pol2qm74	5682	32	to	to	IN
cord-015021-pol2qm74	5682	33	those	those	DT
cord-015021-pol2qm74	5682	34	seen	see	VBN
cord-015021-pol2qm74	5682	35	following	follow	VBG
cord-015021-pol2qm74	5682	36	serious	serious	JJ
cord-015021-pol2qm74	5682	37	injury	injury	NN
cord-015021-pol2qm74	5682	38	.	.	.
cord-015021-pol2qm74	5683	1	Hemodynamic	Hemodynamic	NNP
cord-015021-pol2qm74	5683	2	support	support	NN
cord-015021-pol2qm74	5683	3	is	be	VBZ
cord-015021-pol2qm74	5683	4	based	base	VBN
cord-015021-pol2qm74	5683	5	first	first	RB
cord-015021-pol2qm74	5683	6	on	on	IN
cord-015021-pol2qm74	5683	7	intravenous	intravenous	JJ
cord-015021-pol2qm74	5683	8	fluids	fluid	NNS
cord-015021-pol2qm74	5683	9	and	and	CC
cord-015021-pol2qm74	5683	10	second	second	RB
cord-015021-pol2qm74	5683	11	on	on	IN
cord-015021-pol2qm74	5683	12	vasoactive	vasoactive	JJ
cord-015021-pol2qm74	5683	13	agents	agent	NNS
cord-015021-pol2qm74	5683	14	.	.	.
cord-015021-pol2qm74	5684	1	Colloids	colloid	NNS
cord-015021-pol2qm74	5684	2	are	be	VBP
cord-015021-pol2qm74	5684	3	usually	usually	RB
cord-015021-pol2qm74	5684	4	preferred	prefer	VBN
cord-015021-pol2qm74	5684	5	to	to	IN
cord-015021-pol2qm74	5684	6	crystalloids	crystalloids	NNP
cord-015021-pol2qm74	5684	7	,	,	,
cord-015021-pol2qm74	5684	8	for	for	IN
cord-015021-pol2qm74	5684	9	their	-PRON-	PRP$
cord-015021-pol2qm74	5684	10	more	more	RBR
cord-015021-pol2qm74	5684	11	rapid	rapid	JJ
cord-015021-pol2qm74	5684	12	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	5684	13	effects	effect	NNS
cord-015021-pol2qm74	5684	14	and	and	CC
cord-015021-pol2qm74	5684	15	their	-PRON-	PRP$
cord-015021-pol2qm74	5684	16	lesser	less	JJR
cord-015021-pol2qm74	5684	17	passage	passage	NN
cord-015021-pol2qm74	5684	18	in	in	IN
cord-015021-pol2qm74	5684	19	the	the	DT
cord-015021-pol2qm74	5684	20	interstitial	interstitial	JJ
cord-015021-pol2qm74	5684	21	space	space	NN
cord-015021-pol2qm74	5684	22	.	.	.
cord-015021-pol2qm74	5685	1	In	in	IN
cord-015021-pol2qm74	5685	2	the	the	DT
cord-015021-pol2qm74	5685	3	presence	presence	NN
cord-015021-pol2qm74	5685	4	of	of	IN
cord-015021-pol2qm74	5685	5	hypotension	hypotension	NN
cord-015021-pol2qm74	5685	6	,	,	,
cord-015021-pol2qm74	5685	7	the	the	DT
cord-015021-pol2qm74	5685	8	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	5685	9	profile	profile	NN
cord-015021-pol2qm74	5685	10	of	of	IN
cord-015021-pol2qm74	5685	11	dopamine	dopamine	NN
cord-015021-pol2qm74	5685	12	makes	make	VBZ
cord-015021-pol2qm74	5685	13	it	-PRON-	PRP
cord-015021-pol2qm74	5685	14	the	the	DT
cord-015021-pol2qm74	5685	15	first	first	JJ
cord-015021-pol2qm74	5685	16	agent	agent	NN
cord-015021-pol2qm74	5685	17	of	of	IN
cord-015021-pol2qm74	5685	18	choice	choice	NN
cord-015021-pol2qm74	5685	19	.	.	.
cord-015021-pol2qm74	5686	1	It	-PRON-	PRP
cord-015021-pol2qm74	5686	2	is	be	VBZ
cord-015021-pol2qm74	5686	3	only	only	RB
cord-015021-pol2qm74	5686	4	when	when	WRB
cord-015021-pol2qm74	5686	5	high	high	JJ
cord-015021-pol2qm74	5686	6	doses	dose	NNS
cord-015021-pol2qm74	5686	7	of	of	IN
cord-015021-pol2qm74	5686	8	dopamine	dopamine	NN
cord-015021-pol2qm74	5686	9	are	be	VBP
cord-015021-pol2qm74	5686	10	insufficient	insufficient	JJ
cord-015021-pol2qm74	5686	11	to	to	TO
cord-015021-pol2qm74	5686	12	restore	restore	VB
cord-015021-pol2qm74	5686	13	a	a	DT
cord-015021-pol2qm74	5686	14	sufficient	sufficient	JJ
cord-015021-pol2qm74	5686	15	tissue	tissue	NN
cord-015021-pol2qm74	5686	16	perfusion	perfusion	NN
cord-015021-pol2qm74	5686	17	pressure	pressure	NN
cord-015021-pol2qm74	5686	18	that	that	IN
cord-015021-pol2qm74	5686	19	norepinephrine	norepinephrine	NN
cord-015021-pol2qm74	5686	20	should	should	MD
cord-015021-pol2qm74	5686	21	be	be	VB
cord-015021-pol2qm74	5686	22	added	add	VBN
cord-015021-pol2qm74	5686	23	.	.	.
cord-015021-pol2qm74	5687	1	Even	even	RB
cord-015021-pol2qm74	5687	2	when	when	WRB
cord-015021-pol2qm74	5687	3	cardiac	cardiac	JJ
cord-015021-pol2qm74	5687	4	output	output	NN
cord-015021-pol2qm74	5687	5	is	be	VBZ
cord-015021-pol2qm74	5687	6	not	not	RB
cord-015021-pol2qm74	5687	7	decreased	decrease	VBN
cord-015021-pol2qm74	5687	8	,	,	,
cord-015021-pol2qm74	5687	9	a	a	DT
cord-015021-pol2qm74	5687	10	dobutamine	dobutamine	JJ
cord-015021-pol2qm74	5687	11	infusion	infusion	NN
cord-015021-pol2qm74	5687	12	is	be	VBZ
cord-015021-pol2qm74	5687	13	often	often	RB
cord-015021-pol2qm74	5687	14	indicated	indicate	VBN
cord-015021-pol2qm74	5687	15	to	to	TO
cord-015021-pol2qm74	5687	16	counteract	counteract	VB
cord-015021-pol2qm74	5687	17	the	the	DT
cord-015021-pol2qm74	5687	18	myocardial	myocardial	JJ
cord-015021-pol2qm74	5687	19	depression	depression	NN
cord-015021-pol2qm74	5687	20	,	,	,
cord-015021-pol2qm74	5687	21	prevent	prevent	VB
cord-015021-pol2qm74	5687	22	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	5687	23	,	,	,
cord-015021-pol2qm74	5687	24	and	and	CC
cord-015021-pol2qm74	5687	25	increase	increase	VB
cord-015021-pol2qm74	5687	26	oxygen	oxygen	NN
cord-015021-pol2qm74	5687	27	delivery	delivery	NN
cord-015021-pol2qm74	5687	28	to	to	IN
cord-015021-pol2qm74	5687	29	the	the	DT
cord-015021-pol2qm74	5687	30	tissues	tissue	NNS
cord-015021-pol2qm74	5687	31	.	.	.
cord-015021-pol2qm74	5688	1	The	the	DT
cord-015021-pol2qm74	5688	2	benefit	benefit	NN
cord-015021-pol2qm74	5688	3	derived	derive	VBN
cord-015021-pol2qm74	5688	4	from	from	IN
cord-015021-pol2qm74	5688	5	the	the	DT
cord-015021-pol2qm74	5688	6	administration	administration	NN
cord-015021-pol2qm74	5688	7	of	of	IN
cord-015021-pol2qm74	5688	8	"	"	``
cord-015021-pol2qm74	5688	9	renal	renal	JJ
cord-015021-pol2qm74	5688	10	"	"	''
cord-015021-pol2qm74	5688	11	doses	dose	NNS
cord-015021-pol2qm74	5688	12	of	of	IN
cord-015021-pol2qm74	5688	13	dopamine	dopamine	NN
cord-015021-pol2qm74	5688	14	is	be	VBZ
cord-015021-pol2qm74	5688	15	doubtful	doubtful	JJ
cord-015021-pol2qm74	5688	16	,	,	,
cord-015021-pol2qm74	5688	17	but	but	CC
cord-015021-pol2qm74	5688	18	stimulation	stimulation	NN
cord-015021-pol2qm74	5688	19	of	of	IN
cord-015021-pol2qm74	5688	20	dopaminergic	dopaminergic	JJ
cord-015021-pol2qm74	5688	21	receptors	receptor	NNS
cord-015021-pol2qm74	5688	22	may	may	MD
cord-015021-pol2qm74	5688	23	increase	increase	VB
cord-015021-pol2qm74	5688	24	blood	blood	NN
cord-015021-pol2qm74	5688	25	flow	flow	NN
cord-015021-pol2qm74	5688	26	also	also	RB
cord-015021-pol2qm74	5688	27	to	to	IN
cord-015021-pol2qm74	5688	28	the	the	DT
cord-015021-pol2qm74	5688	29	gut	gut	NN
cord-015021-pol2qm74	5688	30	.	.	.
cord-015021-pol2qm74	5689	1	In	in	IN
cord-015021-pol2qm74	5689	2	any	any	DT
cord-015021-pol2qm74	5689	3	case	case	NN
cord-015021-pol2qm74	5689	4	,	,	,
cord-015021-pol2qm74	5689	5	none	none	NN
cord-015021-pol2qm74	5689	6	of	of	IN
cord-015021-pol2qm74	5689	7	these	these	DT
cord-015021-pol2qm74	5689	8	catecholamines	catecholamine	NNS
cord-015021-pol2qm74	5689	9	has	have	VBZ
cord-015021-pol2qm74	5689	10	been	be	VBN
cord-015021-pol2qm74	5689	11	shown	show	VBN
cord-015021-pol2qm74	5689	12	to	to	TO
cord-015021-pol2qm74	5689	13	significantly	significantly	RB
cord-015021-pol2qm74	5689	14	improve	improve	VB
cord-015021-pol2qm74	5689	15	the	the	DT
cord-015021-pol2qm74	5689	16	oxygen	oxygen	NN
cord-015021-pol2qm74	5689	17	extraction	extraction	NN
cord-015021-pol2qm74	5689	18	capabilities	capability	NNS
cord-015021-pol2qm74	5689	19	of	of	IN
cord-015021-pol2qm74	5689	20	the	the	DT
cord-015021-pol2qm74	5689	21	tissues	tissue	NNS
cord-015021-pol2qm74	5689	22	.	.	.
cord-015021-pol2qm74	5690	1	Agents	agent	NNS
cord-015021-pol2qm74	5690	2	with	with	IN
cord-015021-pol2qm74	5690	3	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	5690	4	properties	property	NNS
cord-015021-pol2qm74	5690	5	but	but	CC
cord-015021-pol2qm74	5690	6	also	also	RB
cord-015021-pol2qm74	5690	7	with	with	IN
cord-015021-pol2qm74	5690	8	some	some	DT
cord-015021-pol2qm74	5690	9	vasodilating	vasodilating	NN
cord-015021-pol2qm74	5690	10	properties	property	NNS
cord-015021-pol2qm74	5690	11	,	,	,
cord-015021-pol2qm74	5690	12	such	such	JJ
cord-015021-pol2qm74	5690	13	as	as	IN
cord-015021-pol2qm74	5690	14	N	n	CD
cord-015021-pol2qm74	5690	15	-	-	HYPH
cord-015021-pol2qm74	5690	16	acetylcysteine	acetylcysteine	NN
cord-015021-pol2qm74	5690	17	,	,	,
cord-015021-pol2qm74	5690	18	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	5690	19	El	El	NNP
cord-015021-pol2qm74	5690	20	or	or	CC
cord-015021-pol2qm74	5690	21	pentoxifylline	pentoxifylline	NNP
cord-015021-pol2qm74	5690	22	represent	represent	VBP
cord-015021-pol2qm74	5690	23	more	more	RBR
cord-015021-pol2qm74	5690	24	attractive	attractive	JJ
cord-015021-pol2qm74	5690	25	options	option	NNS
cord-015021-pol2qm74	5690	26	to	to	TO
cord-015021-pol2qm74	5690	27	increase	increase	VB
cord-015021-pol2qm74	5690	28	oxygen	oxygen	NN
cord-015021-pol2qm74	5690	29	extraction	extraction	NN
cord-015021-pol2qm74	5690	30	.	.	.
cord-015021-pol2qm74	5691	1	Cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	5691	2	support	support	NN
cord-015021-pol2qm74	5691	3	should	should	MD
cord-015021-pol2qm74	5691	4	aim	aim	VB
cord-015021-pol2qm74	5691	5	not	not	RB
cord-015021-pol2qm74	5691	6	only	only	RB
cord-015021-pol2qm74	5691	7	at	at	IN
cord-015021-pol2qm74	5691	8	the	the	DT
cord-015021-pol2qm74	5691	9	restoration	restoration	NN
cord-015021-pol2qm74	5691	10	of	of	IN
cord-015021-pol2qm74	5691	11	a	a	DT
cord-015021-pol2qm74	5691	12	sufficient	sufficient	JJ
cord-015021-pol2qm74	5691	13	arterial	arterial	JJ
cord-015021-pol2qm74	5691	14	pressure	pressure	NN
cord-015021-pol2qm74	5691	15	but	but	CC
cord-015021-pol2qm74	5691	16	also	also	RB
cord-015021-pol2qm74	5691	17	at	at	IN
cord-015021-pol2qm74	5691	18	the	the	DT
cord-015021-pol2qm74	5691	19	maintenance	maintenance	NN
cord-015021-pol2qm74	5691	20	of	of	IN
cord-015021-pol2qm74	5691	21	an	an	DT
cord-015021-pol2qm74	5691	22	optimal	optimal	JJ
cord-015021-pol2qm74	5691	23	oxygen	oxygen	NN
cord-015021-pol2qm74	5691	24	delivery	delivery	NN
cord-015021-pol2qm74	5691	25	to	to	IN
cord-015021-pol2qm74	5691	26	the	the	DT
cord-015021-pol2qm74	5691	27	cells	cell	NNS
cord-015021-pol2qm74	5691	28	.	.	.
cord-015021-pol2qm74	5692	1	It	-PRON-	PRP
cord-015021-pol2qm74	5692	2	should	should	MD
cord-015021-pol2qm74	5692	3	thus	thus	RB
cord-015021-pol2qm74	5692	4	be	be	VB
cord-015021-pol2qm74	5692	5	guided	guide	VBN
cord-015021-pol2qm74	5692	6	also	also	RB
cord-015021-pol2qm74	5692	7	by	by	IN
cord-015021-pol2qm74	5692	8	measurements	measurement	NNS
cord-015021-pol2qm74	5692	9	of	of	IN
cord-015021-pol2qm74	5692	10	cardiac	cardiac	JJ
cord-015021-pol2qm74	5692	11	output	output	NN
cord-015021-pol2qm74	5692	12	,	,	,
cord-015021-pol2qm74	5692	13	mixed	mixed	JJ
cord-015021-pol2qm74	5692	14	venous	venous	JJ
cord-015021-pol2qm74	5692	15	oxygen	oxygen	NN
cord-015021-pol2qm74	5692	16	saturation	saturation	NN
cord-015021-pol2qm74	5692	17	and	and	CC
cord-015021-pol2qm74	5692	18	oxygen	oxygen	NN
cord-015021-pol2qm74	5692	19	extraction	extraction	NN
cord-015021-pol2qm74	5692	20	,	,	,
cord-015021-pol2qm74	5692	21	and	and	CC
cord-015021-pol2qm74	5692	22	indexes	index	NNS
cord-015021-pol2qm74	5692	23	of	of	IN
cord-015021-pol2qm74	5692	24	cellular	cellular	JJ
cord-015021-pol2qm74	5692	25	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5692	26	,	,	,
cord-015021-pol2qm74	5692	27	such	such	JJ
cord-015021-pol2qm74	5692	28	as	as	IN
cord-015021-pol2qm74	5692	29	blood	blood	NN
cord-015021-pol2qm74	5692	30	lactate	lactate	NN
cord-015021-pol2qm74	5692	31	levels	level	NNS
cord-015021-pol2qm74	5692	32	,	,	,
cord-015021-pol2qm74	5692	33	gastric	gastric	JJ
cord-015021-pol2qm74	5692	34	intramucosal	intramucosal	NN
cord-015021-pol2qm74	5692	35	pH	ph	NN
cord-015021-pol2qm74	5692	36	or	or	CC
cord-015021-pol2qm74	5692	37	vanearterial	vanearterial	JJ
cord-015021-pol2qm74	5692	38	PC02	PC02	NNP
cord-015021-pol2qm74	5692	39	gradients	gradient	NNS
cord-015021-pol2qm74	5692	40	.	.	.
cord-015021-pol2qm74	5692	41	 	 	_SP
cord-015021-pol2qm74	5693	1	Supranorma	Supranorma	NNP
cord-015021-pol2qm74	5693	2	[	[	-LRB-
cord-015021-pol2qm74	5693	3	02	02	CD
cord-015021-pol2qm74	5693	4	delivery	delivery	NN
cord-015021-pol2qm74	5693	5	contributes	contribute	VBZ
cord-015021-pol2qm74	5693	6	to	to	IN
cord-015021-pol2qm74	5693	7	the	the	DT
cord-015021-pol2qm74	5693	8	prevention	prevention	NN
cord-015021-pol2qm74	5693	9	of	of	IN
cord-015021-pol2qm74	5693	10	tissue	tissue	NN
cord-015021-pol2qm74	5693	11	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5693	12	Tissue	tissue	NN
cord-015021-pol2qm74	5693	13	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5693	14	is	be	VBZ
cord-015021-pol2qm74	5693	15	considered	consider	VBN
cord-015021-pol2qm74	5693	16	to	to	TO
cord-015021-pol2qm74	5693	17	be	be	VB
cord-015021-pol2qm74	5693	18	the	the	DT
cord-015021-pol2qm74	5693	19	common	common	JJ
cord-015021-pol2qm74	5693	20	final	final	JJ
cord-015021-pol2qm74	5693	21	pathway	pathway	NN
cord-015021-pol2qm74	5693	22	in	in	IN
cord-015021-pol2qm74	5693	23	the	the	DT
cord-015021-pol2qm74	5693	24	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	5693	25	of	of	IN
cord-015021-pol2qm74	5693	26	multipte	multipte	NNP
cord-015021-pol2qm74	5693	27	systems	system	NNS
cord-015021-pol2qm74	5693	28	organ	organ	NN
cord-015021-pol2qm74	5693	29	failure	failure	NN
cord-015021-pol2qm74	5693	30	.	.	.
cord-015021-pol2qm74	5694	1	It	-PRON-	PRP
cord-015021-pol2qm74	5694	2	may	may	MD
cord-015021-pol2qm74	5694	3	directly	directly	RB
cord-015021-pol2qm74	5694	4	contribute	contribute	VB
cord-015021-pol2qm74	5694	5	to	to	IN
cord-015021-pol2qm74	5694	6	cellular	cellular	JJ
cord-015021-pol2qm74	5694	7	injury	injury	NN
cord-015021-pol2qm74	5694	8	and	and	CC
cord-015021-pol2qm74	5694	9	organ	organ	NN
cord-015021-pol2qm74	5694	10	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5694	11	as	as	RB
cord-015021-pol2qm74	5694	12	well	well	RB
cord-015021-pol2qm74	5694	13	as	as	IN
cord-015021-pol2qm74	5694	14	enhance	enhance	VB
cord-015021-pol2qm74	5694	15	further	further	JJ
cord-015021-pol2qm74	5694	16	mediator	mediator	NN
cord-015021-pol2qm74	5694	17	activation	activation	NN
cord-015021-pol2qm74	5694	18	and	and	CC
cord-015021-pol2qm74	5694	19	release	release	NN
cord-015021-pol2qm74	5694	20	by	by	IN
cord-015021-pol2qm74	5694	21	a	a	DT
cord-015021-pol2qm74	5694	22	positive	positive	JJ
cord-015021-pol2qm74	5694	23	feed	feed	NN
cord-015021-pol2qm74	5694	24	back	back	NN
cord-015021-pol2qm74	5694	25	mechanism	mechanism	NN
cord-015021-pol2qm74	5694	26	.	.	.
cord-015021-pol2qm74	5695	1	Prevention	prevention	NN
cord-015021-pol2qm74	5695	2	of	of	IN
cord-015021-pol2qm74	5695	3	tissue	tissue	NN
cord-015021-pol2qm74	5695	4	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5695	5	,	,	,
cord-015021-pol2qm74	5695	6	is	be	VBZ
cord-015021-pol2qm74	5695	7	therefore	therefore	RB
cord-015021-pol2qm74	5695	8	,	,	,
cord-015021-pol2qm74	5695	9	one	one	CD
cord-015021-pol2qm74	5695	10	of	of	IN
cord-015021-pol2qm74	5695	11	the	the	DT
cord-015021-pol2qm74	5695	12	most	most	RBS
cord-015021-pol2qm74	5695	13	important	important	JJ
cord-015021-pol2qm74	5695	14	aims	aim	NNS
cord-015021-pol2qm74	5695	15	in	in	IN
cord-015021-pol2qm74	5695	16	the	the	DT
cord-015021-pol2qm74	5695	17	supportive	supportive	JJ
cord-015021-pol2qm74	5695	18	therapy	therapy	NN
cord-015021-pol2qm74	5695	19	of	of	IN
cord-015021-pol2qm74	5695	20	critically	critically	RB
cord-015021-pol2qm74	5695	21	ill	ill	JJ
cord-015021-pol2qm74	5695	22	patients	patient	NNS
cord-015021-pol2qm74	5695	23	,	,	,
cord-015021-pol2qm74	5695	24	especially	especially	RB
cord-015021-pol2qm74	5695	25	in	in	IN
cord-015021-pol2qm74	5695	26	those	those	DT
cord-015021-pol2qm74	5695	27	with	with	IN
cord-015021-pol2qm74	5695	28	sepsis	sepsis	NN
cord-015021-pol2qm74	5695	29	and	and	CC
cord-015021-pol2qm74	5695	30	septic	septic	JJ
cord-015021-pol2qm74	5695	31	shock	shock	NN
cord-015021-pol2qm74	5695	32	.	.	.
cord-015021-pol2qm74	5696	1	Mismatch	mismatch	NN
cord-015021-pol2qm74	5696	2	of	of	IN
cord-015021-pol2qm74	5696	3	cellular	cellular	JJ
cord-015021-pol2qm74	5696	4	O=	O=	NNP
cord-015021-pol2qm74	5696	5	supply	supply	NN
cord-015021-pol2qm74	5696	6	and	and	CC
cord-015021-pol2qm74	5696	7	demand	demand	NN
cord-015021-pol2qm74	5696	8	in	in	IN
cord-015021-pol2qm74	5696	9	these	these	DT
cord-015021-pol2qm74	5696	10	patients	patient	NNS
cord-015021-pol2qm74	5696	11	may	may	MD
cord-015021-pol2qm74	5696	12	resuit	resuit	VB
cord-015021-pol2qm74	5696	13	from	from	IN
cord-015021-pol2qm74	5696	14	the	the	DT
cord-015021-pol2qm74	5696	15	impairment	impairment	NN
cord-015021-pol2qm74	5696	16	of	of	IN
cord-015021-pol2qm74	5696	17	the	the	DT
cord-015021-pol2qm74	5696	18	cardiocircu[atory	cardiocircu[atory	NN
cord-015021-pol2qm74	5696	19	system	system	NN
cord-015021-pol2qm74	5696	20	on	on	IN
cord-015021-pol2qm74	5696	21	all	all	DT
cord-015021-pol2qm74	5696	22	levels	level	NNS
cord-015021-pol2qm74	5696	23	.	.	.
cord-015021-pol2qm74	5697	1	1	1	LS
cord-015021-pol2qm74	5697	2	.	.	.
cord-015021-pol2qm74	5698	1	Myocardial	myocardial	JJ
cord-015021-pol2qm74	5698	2	depression	depression	NN
cord-015021-pol2qm74	5698	3	with	with	IN
cord-015021-pol2qm74	5698	4	a	a	DT
cord-015021-pol2qm74	5698	5	drop	drop	NN
cord-015021-pol2qm74	5698	6	in	in	IN
cord-015021-pol2qm74	5698	7	02	02	CD
cord-015021-pol2qm74	5698	8	delivery	delivery	NN
cord-015021-pol2qm74	5698	9	(	(	-LRB-
cord-015021-pol2qm74	5698	10	DO~	DO~	NNP
cord-015021-pol2qm74	5698	11	)	)	-RRB-
cord-015021-pol2qm74	5698	12	2	2	CD
cord-015021-pol2qm74	5698	13	.	.	.
cord-015021-pol2qm74	5699	1	Redistribution	redistribution	NN
cord-015021-pol2qm74	5699	2	of	of	IN
cord-015021-pol2qm74	5699	3	blood	blood	NN
cord-015021-pol2qm74	5699	4	flow	flow	NN
cord-015021-pol2qm74	5699	5	between	between	IN
cord-015021-pol2qm74	5699	6	the	the	DT
cord-015021-pol2qm74	5699	7	different	different	JJ
cord-015021-pol2qm74	5699	8	organ	organ	NN
cord-015021-pol2qm74	5699	9	systems	system	NNS
cord-015021-pol2qm74	5699	10	3	3	CD
cord-015021-pol2qm74	5699	11	.	.	.
cord-015021-pol2qm74	5700	1	inadequate	inadequate	JJ
cord-015021-pol2qm74	5700	2	nutritive	nutritive	JJ
cord-015021-pol2qm74	5700	3	blood	blood	NN
cord-015021-pol2qm74	5700	4	flow	flow	NN
cord-015021-pol2qm74	5700	5	due	due	IN
cord-015021-pol2qm74	5700	6	to	to	IN
cord-015021-pol2qm74	5700	7	tissue	tissue	NN
cord-015021-pol2qm74	5700	8	edema	edema	NN
cord-015021-pol2qm74	5700	9	and	and	CC
cord-015021-pol2qm74	5700	10	endothelial	endothelial	JJ
cord-015021-pol2qm74	5700	11	damage	damage	NN
cord-015021-pol2qm74	5701	1	(	(	-LRB-
cord-015021-pol2qm74	5701	2	gIC	gIC	NNP
cord-015021-pol2qm74	5701	3	,	,	,
cord-015021-pol2qm74	5701	4	leucocyte	leucocyte	NNP
cord-015021-pol2qm74	5701	5	swelling	swell	VBG
cord-015021-pol2qm74	5701	6	etc	etc	NN
cord-015021-pol2qm74	5701	7	.	.	.
cord-015021-pol2qm74	5701	8	)	)	-RRB-
cord-015021-pol2qm74	5702	1	These	these	DT
cord-015021-pol2qm74	5702	2	pathological	pathological	JJ
cord-015021-pol2qm74	5702	3	changes	change	NNS
cord-015021-pol2qm74	5702	4	may	may	MD
cord-015021-pol2qm74	5702	5	go	go	VB
cord-015021-pol2qm74	5702	6	along	along	RB
cord-015021-pol2qm74	5702	7	with	with	IN
cord-015021-pol2qm74	5702	8	increased	increase	VBN
cord-015021-pol2qm74	5702	9	metabolic	metabolic	JJ
cord-015021-pol2qm74	5702	10	needs	need	NNS
cord-015021-pol2qm74	5702	11	.	.	.
cord-015021-pol2qm74	5703	1	Cellular	cellular	JJ
cord-015021-pol2qm74	5703	2	and	and	CC
cord-015021-pol2qm74	5703	3	organ	organ	NN
cord-015021-pol2qm74	5703	4	02	02	CD
cord-015021-pol2qm74	5703	5	supply	supply	NN
cord-015021-pol2qm74	5703	6	may	may	MD
cord-015021-pol2qm74	5703	7	therefore	therefore	RB
cord-015021-pol2qm74	5703	8	be	be	VB
cord-015021-pol2qm74	5703	9	inadequately	inadequately	RB
cord-015021-pol2qm74	5703	10	matched	match	VBN
cord-015021-pol2qm74	5703	11	with	with	IN
cord-015021-pol2qm74	5703	12	cellular	cellular	JJ
cord-015021-pol2qm74	5703	13	02	02	CD
cord-015021-pol2qm74	5703	14	needs	need	NNS
cord-015021-pol2qm74	5703	15	in	in	IN
cord-015021-pol2qm74	5703	16	patients	patient	NNS
cord-015021-pol2qm74	5703	17	with	with	IN
cord-015021-pol2qm74	5703	18	normal	normal	JJ
cord-015021-pol2qm74	5703	19	and	and	CC
cord-015021-pol2qm74	5703	20	even	even	RB
cord-015021-pol2qm74	5703	21	supral	supral	JJ
cord-015021-pol2qm74	5703	22	normal	normal	JJ
cord-015021-pol2qm74	5703	23	DOz	DOz	NNS
cord-015021-pol2qm74	5703	24	.	.	.
cord-015021-pol2qm74	5704	1	Hyperdynamic	Hyperdynamic	NNP
cord-015021-pol2qm74	5704	2	circulation	circulation	NN
cord-015021-pol2qm74	5704	3	is	be	VBZ
cord-015021-pol2qm74	5704	4	often	often	RB
cord-015021-pol2qm74	5704	5	present	present	JJ
cord-015021-pol2qm74	5704	6	in	in	IN
cord-015021-pol2qm74	5704	7	adequately	adequately	RB
cord-015021-pol2qm74	5704	8	volume	volume	NN
cord-015021-pol2qm74	5704	9	resusucitated	resusucitate	VBN
cord-015021-pol2qm74	5704	10	patients	patient	NNS
cord-015021-pol2qm74	5704	11	.	.	.
cord-015021-pol2qm74	5705	1	It	-PRON-	PRP
cord-015021-pol2qm74	5705	2	is	be	VBZ
cord-015021-pol2qm74	5705	3	most	most	RBS
cord-015021-pol2qm74	5705	4	likely	likely	JJ
cord-015021-pol2qm74	5705	5	that	that	IN
cord-015021-pol2qm74	5705	6	one	one	CD
cord-015021-pol2qm74	5705	7	of	of	IN
cord-015021-pol2qm74	5705	8	the	the	DT
cord-015021-pol2qm74	5705	9	bodys	bodys	JJ
cord-015021-pol2qm74	5705	10	main	main	JJ
cord-015021-pol2qm74	5705	11	compensatory	compensatory	JJ
cord-015021-pol2qm74	5705	12	mechanisms	mechanism	NNS
cord-015021-pol2qm74	5705	13	would	would	MD
cord-015021-pol2qm74	5705	14	maintain	maintain	VB
cord-015021-pol2qm74	5705	15	cellular	cellular	JJ
cord-015021-pol2qm74	5705	16	O=	O=	NNP
cord-015021-pol2qm74	5705	17	supply	supply	NN
cord-015021-pol2qm74	5705	18	in	in	IN
cord-015021-pol2qm74	5705	19	the	the	DT
cord-015021-pol2qm74	5705	20	face	face	NN
cord-015021-pol2qm74	5705	21	of	of	IN
cord-015021-pol2qm74	5705	22	increased	increase	VBN
cord-015021-pol2qm74	5705	23	metabolic	metabolic	JJ
cord-015021-pol2qm74	5705	24	needs	need	NNS
cord-015021-pol2qm74	5705	25	and	and	CC
cord-015021-pol2qm74	5705	26	impaired	impair	VBN
cord-015021-pol2qm74	5705	27	Oz	Oz	NNP
cord-015021-pol2qm74	5705	28	extraction	extraction	NN
cord-015021-pol2qm74	5705	29	capabillities	capabillitie	NNS
cord-015021-pol2qm74	5705	30	.	.	.
cord-015021-pol2qm74	5706	1	This	this	DT
cord-015021-pol2qm74	5706	2	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	5706	3	may	may	MD
cord-015021-pol2qm74	5706	4	explain	explain	VB
cord-015021-pol2qm74	5706	5	the	the	DT
cord-015021-pol2qm74	5706	6	findings	finding	NNS
cord-015021-pol2qm74	5706	7	in	in	IN
cord-015021-pol2qm74	5706	8	several	several	JJ
cord-015021-pol2qm74	5706	9	clinical	clinical	JJ
cord-015021-pol2qm74	5706	10	investigations	investigation	NNS
cord-015021-pol2qm74	5706	11	that	that	WDT
cord-015021-pol2qm74	5706	12	patients	patient	NNS
cord-015021-pol2qm74	5706	13	with	with	IN
cord-015021-pol2qm74	5706	14	normal	normal	JJ
cord-015021-pol2qm74	5706	15	or	or	CC
cord-015021-pol2qm74	5706	16	even	even	RB
cord-015021-pol2qm74	5706	17	supranormal	supranormal	JJ
cord-015021-pol2qm74	5706	18	DOz	DOz	NNS
cord-015021-pol2qm74	5706	19	can	can	MD
cord-015021-pol2qm74	5706	20	have	have	VB
cord-015021-pol2qm74	5706	21	signs	sign	NNS
cord-015021-pol2qm74	5706	22	of	of	IN
cord-015021-pol2qm74	5706	23	inadequate	inadequate	JJ
cord-015021-pol2qm74	5706	24	regional	regional	JJ
cord-015021-pol2qm74	5706	25	tissue	tissue	NN
cord-015021-pol2qm74	5706	26	oxygenation	oxygenation	NN
cord-015021-pol2qm74	5706	27	.	.	.
cord-015021-pol2qm74	5707	1	It	-PRON-	PRP
cord-015021-pol2qm74	5707	2	is	be	VBZ
cord-015021-pol2qm74	5707	3	also	also	RB
cord-015021-pol2qm74	5707	4	consistent	consistent	JJ
cord-015021-pol2qm74	5707	5	with	with	IN
cord-015021-pol2qm74	5707	6	the	the	DT
cord-015021-pol2qm74	5707	7	results	result	NNS
cord-015021-pol2qm74	5707	8	of	of	IN
cord-015021-pol2qm74	5707	9	different	different	JJ
cord-015021-pol2qm74	5707	10	studies	study	NNS
cord-015021-pol2qm74	5707	11	which	which	WDT
cord-015021-pol2qm74	5707	12	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	5707	13	that	that	IN
cord-015021-pol2qm74	5707	14	the	the	DT
cord-015021-pol2qm74	5707	15	achievement	achievement	NN
cord-015021-pol2qm74	5707	16	of	of	IN
cord-015021-pol2qm74	5707	17	supranormal	supranormal	JJ
cord-015021-pol2qm74	5707	18	DOz	DOz	NNS
cord-015021-pol2qm74	5707	19	levels	level	NNS
cord-015021-pol2qm74	5707	20	,	,	,
cord-015021-pol2qm74	5707	21	either	either	CC
cord-015021-pol2qm74	5707	22	spontanuously	spontanuously	RB
cord-015021-pol2qm74	5707	23	or	or	CC
cord-015021-pol2qm74	5707	24	due	due	JJ
cord-015021-pol2qm74	5707	25	to	to	TO
cord-015021-pol2qm74	5707	26	adequate	adequate	JJ
cord-015021-pol2qm74	5707	27	supportive	supportive	JJ
cord-015021-pol2qm74	5707	28	therapy	therapy	NN
cord-015021-pol2qm74	5707	29	,	,	,
cord-015021-pol2qm74	5707	30	resuits	resuit	NNS
cord-015021-pol2qm74	5707	31	in	in	IN
cord-015021-pol2qm74	5707	32	better	well	JJR
cord-015021-pol2qm74	5707	33	patient	patient	JJ
cord-015021-pol2qm74	5707	34	outcome	outcome	NN
cord-015021-pol2qm74	5707	35	.	.	.
cord-015021-pol2qm74	5708	1	Any	any	DT
cord-015021-pol2qm74	5708	2	attempt	attempt	NN
cord-015021-pol2qm74	5708	3	to	to	TO
cord-015021-pol2qm74	5708	4	prevent	prevent	VB
cord-015021-pol2qm74	5708	5	or	or	CC
cord-015021-pol2qm74	5708	6	treat	treat	VB
cord-015021-pol2qm74	5708	7	tissue	tissue	NN
cord-015021-pol2qm74	5708	8	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5708	9	in	in	IN
cord-015021-pol2qm74	5708	10	these	these	DT
cord-015021-pol2qm74	5708	11	patients	patient	NNS
cord-015021-pol2qm74	5708	12	,	,	,
cord-015021-pol2qm74	5708	13	however	however	RB
cord-015021-pol2qm74	5708	14	,	,	,
cord-015021-pol2qm74	5708	15	has	have	VBZ
cord-015021-pol2qm74	5708	16	to	to	TO
cord-015021-pol2qm74	5708	17	take	take	VB
cord-015021-pol2qm74	5708	18	into	into	IN
cord-015021-pol2qm74	5708	19	account	account	NN
cord-015021-pol2qm74	5708	20	the	the	DT
cord-015021-pol2qm74	5708	21	effects	effect	NNS
cord-015021-pol2qm74	5708	22	of	of	IN
cord-015021-pol2qm74	5708	23	therapy	therapy	NN
cord-015021-pol2qm74	5708	24	not	not	RB
cord-015021-pol2qm74	5708	25	only	only	RB
cord-015021-pol2qm74	5708	26	on	on	IN
cord-015021-pol2qm74	5708	27	global	global	JJ
cord-015021-pol2qm74	5708	28	Dgz	Dgz	NNP
cord-015021-pol2qm74	5708	29	but	but	CC
cord-015021-pol2qm74	5708	30	especially	especially	RB
cord-015021-pol2qm74	5708	31	on	on	IN
cord-015021-pol2qm74	5708	32	regional	regional	JJ
cord-015021-pol2qm74	5708	33	and	and	CC
cord-015021-pol2qm74	5708	34	microcirculatory	microcirculatory	JJ
cord-015021-pol2qm74	5708	35	blood	blood	NN
cord-015021-pol2qm74	5708	36	flow	flow	NN
cord-015021-pol2qm74	5708	37	.	.	.
cord-015021-pol2qm74	5709	1	R.	R.	NNP
cord-015021-pol2qm74	5709	2	Rossaint	Rossaint	NNP
cord-015021-pol2qm74	5709	3	,	,	,
cord-015021-pol2qm74	5709	4	D.	D.	NNP
cord-015021-pol2qm74	5709	5	Pappert	Pappert	NNP
cord-015021-pol2qm74	5709	6	,	,	,
cord-015021-pol2qm74	5709	7	K.	K.	NNP
cord-015021-pol2qm74	5709	8	Lewandowski	Lewandowski	NNP
cord-015021-pol2qm74	5709	9	,	,	,
cord-015021-pol2qm74	5709	10	H.	H.	NNP
cord-015021-pol2qm74	5709	11	Gedach	Gedach	NNP
cord-015021-pol2qm74	5709	12	,	,	,
cord-015021-pol2qm74	5709	13	K.	K.	NNP
cord-015021-pol2qm74	5709	14	Slama	Slama	NNP
cord-015021-pol2qm74	5709	15	,	,	,
cord-015021-pol2qm74	5709	16	K.J.	K.J.	NNP
cord-015021-pol2qm74	5709	17	Falke	Falke	NNP
cord-015021-pol2qm74	5709	18	Klinik	Klinik	NNP
cord-015021-pol2qm74	5709	19	for	for	IN
cord-015021-pol2qm74	5709	20	Anaesthesiologie	Anaesthesiologie	NNP
cord-015021-pol2qm74	5710	1	und	und	NNP
cord-015021-pol2qm74	5711	1	operative	operative	JJ
cord-015021-pol2qm74	5711	2	Intensivmedizin	Intensivmedizin	NNP
cord-015021-pol2qm74	5711	3	,	,	,
cord-015021-pol2qm74	5711	4	UKRV	UKRV	NNP
cord-015021-pol2qm74	5711	5	,	,	,
cord-015021-pol2qm74	5711	6	Freie	Freie	NNP
cord-015021-pol2qm74	5711	7	Universit	Universit	NNP
cord-015021-pol2qm74	5712	1	§	§	NN
cord-015021-pol2qm74	5712	2	t	t	NNP
cord-015021-pol2qm74	5712	3	Berlin	Berlin	NNP
cord-015021-pol2qm74	5712	4	,	,	,
cord-015021-pol2qm74	5712	5	Germany	Germany	NNP
cord-015021-pol2qm74	5712	6	Important	important	JJ
cord-015021-pol2qm74	5712	7	contributory	contributory	JJ
cord-015021-pol2qm74	5712	8	factors	factor	NNS
cord-015021-pol2qm74	5712	9	to	to	IN
cord-015021-pol2qm74	5712	10	the	the	DT
cord-015021-pol2qm74	5712	11	high	high	JJ
cord-015021-pol2qm74	5712	12	mortality	mortality	NN
cord-015021-pol2qm74	5712	13	of	of	IN
cord-015021-pol2qm74	5712	14	severe	severe	JJ
cord-015021-pol2qm74	5712	15	acute	acute	JJ
cord-015021-pol2qm74	5712	16	respiratory	respiratory	JJ
cord-015021-pol2qm74	5712	17	distress	distress	NN
cord-015021-pol2qm74	5712	18	syndrome	syndrome	NN
cord-015021-pol2qm74	5712	19	lARDS	lARDS	NNP
cord-015021-pol2qm74	5712	20	)	)	-RRB-
cord-015021-pol2qm74	5712	21	are	be	VBP
cord-015021-pol2qm74	5712	22	the	the	DT
cord-015021-pol2qm74	5712	23	aggressive	aggressive	JJ
cord-015021-pol2qm74	5712	24	therapies	therapy	NNS
cord-015021-pol2qm74	5712	25	required	require	VBN
cord-015021-pol2qm74	5712	26	,	,	,
cord-015021-pol2qm74	5712	27	such	such	JJ
cord-015021-pol2qm74	5712	28	as	as	IN
cord-015021-pol2qm74	5712	29	mechanical	mechanical	JJ
cord-015021-pol2qm74	5712	30	ventilation	ventilation	NN
cord-015021-pol2qm74	5712	31	with	with	IN
cord-015021-pol2qm74	5712	32	high	high	JJ
cord-015021-pol2qm74	5712	33	inspiratory	inspiratory	JJ
cord-015021-pol2qm74	5712	34	oxygen	oxygen	NN
cord-015021-pol2qm74	5712	35	concentrations	concentration	NNS
cord-015021-pol2qm74	5712	36	and	and	CC
cord-015021-pol2qm74	5712	37	airway	airway	NN
cord-015021-pol2qm74	5712	38	pressures	pressure	NNS
cord-015021-pol2qm74	5712	39	.	.	.
cord-015021-pol2qm74	5713	1	As	as	IN
cord-015021-pol2qm74	5713	2	specific	specific	JJ
cord-015021-pol2qm74	5713	3	therapies	therapy	NNS
cord-015021-pol2qm74	5713	4	for	for	IN
cord-015021-pol2qm74	5713	5	reducing	reduce	VBG
cord-015021-pol2qm74	5713	6	or	or	CC
cord-015021-pol2qm74	5713	7	preventing	prevent	VBG
cord-015021-pol2qm74	5713	8	the	the	DT
cord-015021-pol2qm74	5713	9	general	general	JJ
cord-015021-pol2qm74	5713	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5713	11	reaction	reaction	NN
cord-015021-pol2qm74	5713	12	of	of	IN
cord-015021-pol2qm74	5713	13	the	the	DT
cord-015021-pol2qm74	5713	14	lung	lung	NN
cord-015021-pol2qm74	5713	15	resulting	result	VBG
cord-015021-pol2qm74	5713	16	in	in	IN
cord-015021-pol2qm74	5713	17	severe	severe	JJ
cord-015021-pol2qm74	5713	18	hypoxemia	hypoxemia	NN
cord-015021-pol2qm74	5713	19	is	be	VBZ
cord-015021-pol2qm74	5713	20	unknown	unknown	JJ
cord-015021-pol2qm74	5713	21	,	,	,
cord-015021-pol2qm74	5713	22	today	today	NN
cord-015021-pol2qm74	5713	23	's	's	POS
cord-015021-pol2qm74	5713	24	therapy	therapy	NN
cord-015021-pol2qm74	5713	25	is	be	VBZ
cord-015021-pol2qm74	5713	26	limited	limit	VBN
cord-015021-pol2qm74	5713	27	to	to	IN
cord-015021-pol2qm74	5713	28	procedures	procedure	NNS
cord-015021-pol2qm74	5713	29	which	which	WDT
cord-015021-pol2qm74	5713	30	predominantly	predominantly	RB
cord-015021-pol2qm74	5713	31	support	support	VBP
cord-015021-pol2qm74	5713	32	or	or	CC
cord-015021-pol2qm74	5713	33	maintain	maintain	VB
cord-015021-pol2qm74	5713	34	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	5713	35	function	function	NN
cord-015021-pol2qm74	5713	36	,	,	,
cord-015021-pol2qm74	5713	37	i.e.	i.e.	FW
cord-015021-pol2qm74	5713	38	pressure	pressure	NN
cord-015021-pol2qm74	5713	39	limited	limit	VBN
cord-015021-pol2qm74	5713	40	ventilation	ventilation	NN
cord-015021-pol2qm74	5713	41	with	with	IN
cord-015021-pol2qm74	5713	42	PEEP	peep	NN
cord-015021-pol2qm74	5713	43	and	and	CC
cord-015021-pol2qm74	5713	44	permissive	permissive	JJ
cord-015021-pol2qm74	5713	45	hypercapnea	hypercapnea	NN
cord-015021-pol2qm74	5713	46	,	,	,
cord-015021-pol2qm74	5713	47	avoiding	avoid	VBG
cord-015021-pol2qm74	5713	48	or	or	CC
cord-015021-pol2qm74	5713	49	treatment	treatment	NN
cord-015021-pol2qm74	5713	50	of	of	IN
cord-015021-pol2qm74	5713	51	fluid	fluid	JJ
cord-015021-pol2qm74	5713	52	overloading	overloading	NN
cord-015021-pol2qm74	5713	53	,	,	,
cord-015021-pol2qm74	5713	54	and	and	CC
cord-015021-pol2qm74	5713	55	positional	positional	JJ
cord-015021-pol2qm74	5713	56	maneuvers	maneuver	NNS
cord-015021-pol2qm74	5713	57	.	.	.
cord-015021-pol2qm74	5714	1	Extracorporeal	extracorporeal	JJ
cord-015021-pol2qm74	5714	2	lung	lung	NN
cord-015021-pol2qm74	5714	3	assist	assist	NN
cord-015021-pol2qm74	5714	4	combined	combine	VBN
cord-015021-pol2qm74	5714	5	with	with	IN
cord-015021-pol2qm74	5714	6	low	low	JJ
cord-015021-pol2qm74	5714	7	frequency	frequency	NN
cord-015021-pol2qm74	5714	8	positive	positive	JJ
cord-015021-pol2qm74	5714	9	pressure	pressure	NN
cord-015021-pol2qm74	5714	10	ventilation	ventilation	NN
cord-015021-pol2qm74	5714	11	has	have	VBZ
cord-015021-pol2qm74	5714	12	been	be	VBN
cord-015021-pol2qm74	5714	13	recommended	recommend	VBN
cord-015021-pol2qm74	5714	14	,	,	,
cord-015021-pol2qm74	5714	15	when	when	WRB
cord-015021-pol2qm74	5714	16	conventional	conventional	JJ
cord-015021-pol2qm74	5714	17	therapy	therapy	NN
cord-015021-pol2qm74	5714	18	fails	fail	VBZ
cord-015021-pol2qm74	5714	19	.	.	.
cord-015021-pol2qm74	5715	1	Today	today	NN
cord-015021-pol2qm74	5715	2	,	,	,
cord-015021-pol2qm74	5715	3	extracorporeal	extracorporeal	JJ
cord-015021-pol2qm74	5715	4	gas	gas	NN
cord-015021-pol2qm74	5715	5	exchange	exchange	NN
cord-015021-pol2qm74	5715	6	may	may	MD
cord-015021-pol2qm74	5715	7	be	be	VB
cord-015021-pol2qm74	5715	8	carried	carry	VBN
cord-015021-pol2qm74	5715	9	out	out	RP
cord-015021-pol2qm74	5715	10	using	use	VBG
cord-015021-pol2qm74	5715	11	a	a	DT
cord-015021-pol2qm74	5715	12	system	system	NN
cord-015021-pol2qm74	5715	13	internally	internally	RB
cord-015021-pol2qm74	5715	14	coated	coat	VBD
cord-015021-pol2qm74	5715	15	with	with	IN
cord-015021-pol2qm74	5715	16	covalently	covalently	RB
cord-015021-pol2qm74	5715	17	bound	bind	VBN
cord-015021-pol2qm74	5715	18	heparin	heparin	NN
cord-015021-pol2qm74	5715	19	.	.	.
cord-015021-pol2qm74	5716	1	This	this	DT
cord-015021-pol2qm74	5716	2	allows	allow	VBZ
cord-015021-pol2qm74	5716	3	for	for	IN
cord-015021-pol2qm74	5716	4	a	a	DT
cord-015021-pol2qm74	5716	5	lower	low	JJR
cord-015021-pol2qm74	5716	6	level	level	NN
cord-015021-pol2qm74	5716	7	of	of	IN
cord-015021-pol2qm74	5716	8	systemic	systemic	JJ
cord-015021-pol2qm74	5716	9	heparinzation	heparinzation	NN
cord-015021-pol2qm74	5716	10	reducing	reduce	VBG
cord-015021-pol2qm74	5716	11	the	the	DT
cord-015021-pol2qm74	5716	12	risk	risk	NN
cord-015021-pol2qm74	5716	13	of	of	IN
cord-015021-pol2qm74	5716	14	severe	severe	JJ
cord-015021-pol2qm74	5716	15	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	5716	16	complications	complication	NNS
cord-015021-pol2qm74	5716	17	of	of	IN
cord-015021-pol2qm74	5716	18	extracorporeal	extracorporeal	JJ
cord-015021-pol2qm74	5716	19	respiratory	respiratory	JJ
cord-015021-pol2qm74	5716	20	support	support	NN
cord-015021-pol2qm74	5716	21	.	.	.
cord-015021-pol2qm74	5717	1	From	from	IN
cord-015021-pol2qm74	5717	2	April	April	NNP
cord-015021-pol2qm74	5717	3	1989	1989	CD
cord-015021-pol2qm74	5717	4	to	to	IN
cord-015021-pol2qm74	5717	5	August	August	NNP
cord-015021-pol2qm74	5717	6	1993	1993	CD
cord-015021-pol2qm74	5717	7	89	89	CD
cord-015021-pol2qm74	5717	8	patients	patient	NNS
cord-015021-pol2qm74	5717	9	,	,	,
cord-015021-pol2qm74	5717	10	aged	age	VBN
cord-015021-pol2qm74	5717	11	from	from	IN
cord-015021-pol2qm74	5717	12	15	15	CD
cord-015021-pol2qm74	5717	13	months	month	NNS
cord-015021-pol2qm74	5717	14	to	to	IN
cord-015021-pol2qm74	5717	15	60	60	CD
cord-015021-pol2qm74	5717	16	years	year	NNS
cord-015021-pol2qm74	5717	17	,	,	,
cord-015021-pol2qm74	5717	18	were	be	VBD
cord-015021-pol2qm74	5717	19	transferred	transfer	VBN
cord-015021-pol2qm74	5717	20	to	to	IN
cord-015021-pol2qm74	5717	21	our	-PRON-	PRP$
cord-015021-pol2qm74	5717	22	intensive	intensive	JJ
cord-015021-pol2qm74	5717	23	care	care	NN
cord-015021-pol2qm74	5717	24	unit	unit	NN
cord-015021-pol2qm74	5717	25	(	(	-LRB-
cord-015021-pol2qm74	5717	26	ICU	ICU	NNP
cord-015021-pol2qm74	5717	27	)	)	-RRB-
cord-015021-pol2qm74	5717	28	for	for	IN
cord-015021-pol2qm74	5717	29	treatment	treatment	NN
cord-015021-pol2qm74	5717	30	of	of	IN
cord-015021-pol2qm74	5717	31	severe	severe	JJ
cord-015021-pol2qm74	5717	32	ARDS	ARDS	NNP
cord-015021-pol2qm74	5717	33	.	.	.
cord-015021-pol2qm74	5718	1	All	all	DT
cord-015021-pol2qm74	5718	2	fulfilled	fulfil	VBD
cord-015021-pol2qm74	5718	3	at	at	IN
cord-015021-pol2qm74	5718	4	least	least	JJS
cord-015021-pol2qm74	5718	5	the	the	DT
cord-015021-pol2qm74	5718	6	slow	slow	JJ
cord-015021-pol2qm74	5718	7	entry	entry	NN
cord-015021-pol2qm74	5718	8	criteria	criterion	NNS
cord-015021-pol2qm74	5718	9	of	of	IN
cord-015021-pol2qm74	5718	10	the	the	DT
cord-015021-pol2qm74	5718	11	U.S.	U.S.	NNP
cord-015021-pol2qm74	5718	12	National	National	NNP
cord-015021-pol2qm74	5718	13	ECMO	ECMO	NNP
cord-015021-pol2qm74	5718	14	Study	Study	NNP
cord-015021-pol2qm74	5718	15	.	.	.
cord-015021-pol2qm74	5719	1	Due	due	IN
cord-015021-pol2qm74	5719	2	to	to	IN
cord-015021-pol2qm74	5719	3	hypoxemia	hypoxemia	NN
cord-015021-pol2qm74	5719	4	13	13	CD
cord-015021-pol2qm74	5719	5	patients	patient	NNS
cord-015021-pol2qm74	5719	6	required	require	VBD
cord-015021-pol2qm74	5719	7	veno	veno	NNP
cord-015021-pol2qm74	5719	8	-	-	HYPH
cord-015021-pol2qm74	5719	9	venous	venous	JJ
cord-015021-pol2qm74	5719	10	extracorporeal	extracorporeal	JJ
cord-015021-pol2qm74	5719	11	membrane	membrane	NN
cord-015021-pol2qm74	5719	12	oxygenation	oxygenation	NN
cord-015021-pol2qm74	5719	13	(	(	-LRB-
cord-015021-pol2qm74	5719	14	ECMO	ECMO	NNP
cord-015021-pol2qm74	5719	15	)	)	-RRB-
cord-015021-pol2qm74	5719	16	immediately	immediately	RB
cord-015021-pol2qm74	5719	17	after	after	IN
cord-015021-pol2qm74	5719	18	transfer	transfer	NN
cord-015021-pol2qm74	5719	19	to	to	IN
cord-015021-pol2qm74	5719	20	our	-PRON-	PRP$
cord-015021-pol2qm74	5719	21	ICU	ICU	NNP
cord-015021-pol2qm74	5719	22	.	.	.
cord-015021-pol2qm74	5720	1	The	the	DT
cord-015021-pol2qm74	5720	2	other	other	JJ
cord-015021-pol2qm74	5720	3	76	76	CD
cord-015021-pol2qm74	5720	4	patients	patient	NNS
cord-015021-pol2qm74	5720	5	were	be	VBD
cord-015021-pol2qm74	5720	6	first	first	RB
cord-015021-pol2qm74	5720	7	treated	treat	VBN
cord-015021-pol2qm74	5720	8	with	with	IN
cord-015021-pol2qm74	5720	9	pressure	pressure	NN
cord-015021-pol2qm74	5720	10	controlled	control	VBN
cord-015021-pol2qm74	5720	11	mechanical	mechanical	JJ
cord-015021-pol2qm74	5720	12	ventilation	ventilation	NN
cord-015021-pol2qm74	5720	13	,	,	,
cord-015021-pol2qm74	5720	14	permissive	permissive	JJ
cord-015021-pol2qm74	5720	15	hypercapnea	hypercapnea	NN
cord-015021-pol2qm74	5720	16	,	,	,
cord-015021-pol2qm74	5720	17	prone	prone	JJ
cord-015021-pol2qm74	5720	18	position	position	NN
cord-015021-pol2qm74	5720	19	,	,	,
cord-015021-pol2qm74	5720	20	and	and	CC
cord-015021-pol2qm74	5720	21	dehydration	dehydration	NN
cord-015021-pol2qm74	5720	22	,	,	,
cord-015021-pol2qm74	5720	23	if	if	IN
cord-015021-pol2qm74	5720	24	necessary	necessary	JJ
cord-015021-pol2qm74	5720	25	.	.	.
cord-015021-pol2qm74	5721	1	In	in	IN
cord-015021-pol2qm74	5721	2	23	23	CD
cord-015021-pol2qm74	5721	3	out	out	IN
cord-015021-pol2qm74	5721	4	of	of	IN
cord-015021-pol2qm74	5721	5	these	these	DT
cord-015021-pol2qm74	5721	6	76	76	CD
cord-015021-pol2qm74	5721	7	patients	patient	NNS
cord-015021-pol2qm74	5721	8	,	,	,
cord-015021-pol2qm74	5721	9	in	in	IN
cord-015021-pol2qm74	5721	10	which	which	WDT
cord-015021-pol2qm74	5721	11	the	the	DT
cord-015021-pol2qm74	5721	12	gas	gas	NN
cord-015021-pol2qm74	5721	13	exchange	exchange	NN
cord-015021-pol2qm74	5721	14	did	do	VBD
cord-015021-pol2qm74	5721	15	not	not	RB
cord-015021-pol2qm74	5721	16	improve	improve	VB
cord-015021-pol2qm74	5721	17	in	in	IN
cord-015021-pol2qm74	5721	18	the	the	DT
cord-015021-pol2qm74	5721	19	following	follow	VBG
cord-015021-pol2qm74	5721	20	days	day	NNS
cord-015021-pol2qm74	5721	21	,	,	,
cord-015021-pol2qm74	5721	22	veno	veno	NN
cord-015021-pol2qm74	5721	23	-	-	HYPH
cord-015021-pol2qm74	5721	24	venous	venous	JJ
cord-015021-pol2qm74	5721	25	ECMO	ECMO	NNP
cord-015021-pol2qm74	5721	26	with	with	IN
cord-015021-pol2qm74	5721	27	heparin	heparin	NN
cord-015021-pol2qm74	5721	28	-	-	HYPH
cord-015021-pol2qm74	5721	29	coated	coat	VBN
cord-015021-pol2qm74	5721	30	systems	system	NNS
cord-015021-pol2qm74	5721	31	was	be	VBD
cord-015021-pol2qm74	5721	32	additionally	additionally	RB
cord-015021-pol2qm74	5721	33	performed	perform	VBN
cord-015021-pol2qm74	5721	34	.	.	.
cord-015021-pol2qm74	5722	1	Heparin	Heparin	NNP
cord-015021-pol2qm74	5722	2	was	be	VBD
cord-015021-pol2qm74	5722	3	given	give	VBN
cord-015021-pol2qm74	5722	4	to	to	TO
cord-015021-pol2qm74	5722	5	achieve	achieve	VB
cord-015021-pol2qm74	5722	6	a	a	DT
cord-015021-pol2qm74	5722	7	partial	partial	JJ
cord-015021-pol2qm74	5722	8	thrombin	thrombin	JJ
cord-015021-pol2qm74	5722	9	time	time	NN
cord-015021-pol2qm74	5722	10	between	between	IN
cord-015021-pol2qm74	5722	11	40	40	CD
cord-015021-pol2qm74	5722	12	-55	-55	NNP
cord-015021-pol2qm74	5722	13	s	s	NNP
cord-015021-pol2qm74	5722	14	and	and	CC
cord-015021-pol2qm74	5722	15	an	an	DT
cord-015021-pol2qm74	5722	16	activated	activate	VBN
cord-015021-pol2qm74	5722	17	clotting	clotting	NN
cord-015021-pol2qm74	5722	18	time	time	NN
cord-015021-pol2qm74	5722	19	between	between	IN
cord-015021-pol2qm74	5722	20	120	120	CD
cord-015021-pol2qm74	5723	1	-150	-150	NNP
cord-015021-pol2qm74	5724	1	s.	s.	NNP
cord-015021-pol2qm74	5725	1	If	if	IN
cord-015021-pol2qm74	5725	2	surgery	surgery	NN
cord-015021-pol2qm74	5725	3	was	be	VBD
cord-015021-pol2qm74	5725	4	performed	perform	VBN
cord-015021-pol2qm74	5725	5	during	during	IN
cord-015021-pol2qm74	5725	6	ECMO	ECMO	NNP
cord-015021-pol2qm74	5725	7	,	,	,
cord-015021-pol2qm74	5725	8	heparin	heparin	JJ
cord-015021-pol2qm74	5725	9	infusion	infusion	NN
cord-015021-pol2qm74	5725	10	was	be	VBD
cord-015021-pol2qm74	5725	11	interrupted	interrupt	VBN
cord-015021-pol2qm74	5725	12	.	.	.
cord-015021-pol2qm74	5726	1	No	no	DT
cord-015021-pol2qm74	5726	2	severe	severe	JJ
cord-015021-pol2qm74	5726	3	bleeding	bleeding	JJ
cord-015021-pol2qm74	5726	4	complications	complication	NNS
cord-015021-pol2qm74	5726	5	related	relate	VBN
cord-015021-pol2qm74	5726	6	to	to	IN
cord-015021-pol2qm74	5726	7	anticoagulation	anticoagulation	NN
cord-015021-pol2qm74	5726	8	for	for	IN
cord-015021-pol2qm74	5726	9	the	the	DT
cord-015021-pol2qm74	5726	10	extracorporeal	extracorporeal	JJ
cord-015021-pol2qm74	5726	11	bypass	bypass	NN
cord-015021-pol2qm74	5726	12	could	could	MD
cord-015021-pol2qm74	5726	13	be	be	VB
cord-015021-pol2qm74	5726	14	observed	observe	VBN
cord-015021-pol2qm74	5726	15	,	,	,
cord-015021-pol2qm74	5726	16	however	however	RB
cord-015021-pol2qm74	5726	17	,	,	,
cord-015021-pol2qm74	5726	18	in	in	IN
cord-015021-pol2qm74	5726	19	some	some	DT
cord-015021-pol2qm74	5726	20	patients	patient	NNS
cord-015021-pol2qm74	5726	21	,	,	,
cord-015021-pol2qm74	5726	22	after	after	IN
cord-015021-pol2qm74	5726	23	three	three	CD
cord-015021-pol2qm74	5726	24	weeks	week	NNS
cord-015021-pol2qm74	5726	25	of	of	IN
cord-015021-pol2qm74	5726	26	ECMO	ECMO	NNP
cord-015021-pol2qm74	5726	27	thrombi	thrombi	NNP
cord-015021-pol2qm74	5726	28	in	in	IN
cord-015021-pol2qm74	5726	29	the	the	DT
cord-015021-pol2qm74	5726	30	drainage	drainage	NN
cord-015021-pol2qm74	5726	31	cannula	cannula	NN
cord-015021-pol2qm74	5726	32	were	be	VBD
cord-015021-pol2qm74	5726	33	observed	observe	VBN
cord-015021-pol2qm74	5726	34	.	.	.
cord-015021-pol2qm74	5727	1	A	a	DT
cord-015021-pol2qm74	5727	2	problem	problem	NN
cord-015021-pol2qm74	5727	3	of	of	IN
cord-015021-pol2qm74	5727	4	of	of	IN
cord-015021-pol2qm74	5727	5	membrane	membrane	NN
cord-015021-pol2qm74	5727	6	leakage	leakage	NN
cord-015021-pol2qm74	5727	7	shortened	shorten	VBD
cord-015021-pol2qm74	5727	8	the	the	DT
cord-015021-pol2qm74	5727	9	life	life	NN
cord-015021-pol2qm74	5727	10	span	span	NN
cord-015021-pol2qm74	5727	11	of	of	IN
cord-015021-pol2qm74	5727	12	the	the	DT
cord-015021-pol2qm74	5727	13	membrane	membrane	NN
cord-015021-pol2qm74	5727	14	lungs	lung	VBZ
cord-015021-pol2qm74	5727	15	to	to	IN
cord-015021-pol2qm74	5727	16	a	a	DT
cord-015021-pol2qm74	5727	17	mean	mean	NN
cord-015021-pol2qm74	5727	18	of	of	IN
cord-015021-pol2qm74	5727	19	about	about	RB
cord-015021-pol2qm74	5727	20	four	four	CD
cord-015021-pol2qm74	5727	21	4	4	CD
cord-015021-pol2qm74	5727	22	days	day	NNS
cord-015021-pol2qm74	5727	23	.	.	.
cord-015021-pol2qm74	5728	1	In	in	IN
cord-015021-pol2qm74	5728	2	the	the	DT
cord-015021-pol2qm74	5728	3	conventionally	conventionally	RB
cord-015021-pol2qm74	5728	4	treated	treat	VBN
cord-015021-pol2qm74	5728	5	group	group	NN
cord-015021-pol2qm74	5728	6	87	87	CD
cord-015021-pol2qm74	5728	7	%	%	NN
cord-015021-pol2qm74	5728	8	survived	survive	VBD
cord-015021-pol2qm74	5728	9	and	and	CC
cord-015021-pol2qm74	5728	10	in	in	IN
cord-015021-pol2qm74	5728	11	the	the	DT
cord-015021-pol2qm74	5728	12	additionally	additionally	RB
cord-015021-pol2qm74	5728	13	with	with	IN
cord-015021-pol2qm74	5728	14	ECMO	ECMO	NNP
cord-015021-pol2qm74	5728	15	treated	treat	VBN
cord-015021-pol2qm74	5728	16	group	group	NN
cord-015021-pol2qm74	5728	17	58	58	CD
cord-015021-pol2qm74	5728	18	%	%	NN
cord-015021-pol2qm74	5728	19	survived	survive	VBD
cord-015021-pol2qm74	5728	20	,	,	,
cord-015021-pol2qm74	5728	21	representing	represent	VBG
cord-015021-pol2qm74	5728	22	a	a	DT
cord-015021-pol2qm74	5728	23	75	75	CD
cord-015021-pol2qm74	5728	24	%	%	NN
cord-015021-pol2qm74	5728	25	survival	survival	NN
cord-015021-pol2qm74	5728	26	rate	rate	NN
cord-015021-pol2qm74	5728	27	in	in	IN
cord-015021-pol2qm74	5728	28	patients	patient	NNS
cord-015021-pol2qm74	5728	29	whose	whose	WP$
cord-015021-pol2qm74	5728	30	risk	risk	NN
cord-015021-pol2qm74	5728	31	of	of	IN
cord-015021-pol2qm74	5728	32	death	death	NN
cord-015021-pol2qm74	5728	33	is	be	VBZ
cord-015021-pol2qm74	5728	34	considered	consider	VBN
cord-015021-pol2qm74	5728	35	more	more	JJR
cord-015021-pol2qm74	5728	36	than	than	IN
cord-015021-pol2qm74	5728	37	50	50	CD
cord-015021-pol2qm74	5728	38	%	%	NN
cord-015021-pol2qm74	5728	39	.	.	.
cord-015021-pol2qm74	5729	1	On	on	IN
cord-015021-pol2qm74	5729	2	the	the	DT
cord-015021-pol2qm74	5729	3	basis	basis	NN
cord-015021-pol2qm74	5729	4	of	of	IN
cord-015021-pol2qm74	5729	5	these	these	DT
cord-015021-pol2qm74	5729	6	experiences	experience	NNS
cord-015021-pol2qm74	5729	7	,	,	,
cord-015021-pol2qm74	5729	8	we	-PRON-	PRP
cord-015021-pol2qm74	5729	9	conclude	conclude	VBP
cord-015021-pol2qm74	5729	10	that	that	IN
cord-015021-pol2qm74	5729	11	the	the	DT
cord-015021-pol2qm74	5729	12	described	describe	VBN
cord-015021-pol2qm74	5729	13	strategy	strategy	NN
cord-015021-pol2qm74	5729	14	,	,	,
cord-015021-pol2qm74	5729	15	including	include	VBG
cord-015021-pol2qm74	5729	16	veno	veno	NN
cord-015021-pol2qm74	5729	17	-	-	HYPH
cord-015021-pol2qm74	5729	18	venous	venous	JJ
cord-015021-pol2qm74	5729	19	ECMO	ECMO	NNP
cord-015021-pol2qm74	5729	20	with	with	IN
cord-015021-pol2qm74	5729	21	heparin	heparin	NN
cord-015021-pol2qm74	5729	22	-	-	HYPH
cord-015021-pol2qm74	5729	23	coeted	coete	VBN
cord-015021-pol2qm74	5729	24	systems	system	NNS
cord-015021-pol2qm74	5729	25	,	,	,
cord-015021-pol2qm74	5729	26	may	may	MD
cord-015021-pol2qm74	5729	27	improve	improve	VB
cord-015021-pol2qm74	5729	28	the	the	DT
cord-015021-pol2qm74	5729	29	survival	survival	NN
cord-015021-pol2qm74	5729	30	in	in	IN
cord-015021-pol2qm74	5729	31	patients	patient	NNS
cord-015021-pol2qm74	5729	32	suffering	suffer	VBG
cord-015021-pol2qm74	5729	33	from	from	IN
cord-015021-pol2qm74	5729	34	severe	severe	JJ
cord-015021-pol2qm74	5729	35	ARDS	ARDS	NNP
cord-015021-pol2qm74	5729	36	.	.	.
cord-015021-pol2qm74	5730	1	Abnormally	abnormally	RB
cord-015021-pol2qm74	5730	2	high	high	JJ
cord-015021-pol2qm74	5730	3	skeletal	skeletal	JJ
cord-015021-pol2qm74	5730	4	muscle	muscle	NN
cord-015021-pol2qm74	5730	5	pO	po	NN
cord-015021-pol2qm74	5730	6	2	2	CD
cord-015021-pol2qm74	5730	7	in	in	IN
cord-015021-pol2qm74	5730	8	septic	septic	JJ
cord-015021-pol2qm74	5730	9	patients	patient	NNS
cord-015021-pol2qm74	5730	10	and	and	CC
cord-015021-pol2qm74	5730	11	its	-PRON-	PRP$
cord-015021-pol2qm74	5730	12	normalization	normalization	NN
cord-015021-pol2qm74	5730	13	during	during	IN
cord-015021-pol2qm74	5730	14	recovery	recovery	NN
cord-015021-pol2qm74	5730	15	:	:	:
cord-015021-pol2qm74	5730	16	Evidence	evidence	NN
cord-015021-pol2qm74	5730	17	against	against	IN
cord-015021-pol2qm74	5730	18	tissue	tissue	NN
cord-015021-pol2qm74	5730	19	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5730	20	but	but	CC
cord-015021-pol2qm74	5730	21	for	for	IN
cord-015021-pol2qm74	5730	22	impaired	impaired	JJ
cord-015021-pol2qm74	5730	23	oxygen	oxygen	NN
cord-015021-pol2qm74	5730	24	metabolism	metabolism	NN
cord-015021-pol2qm74	5730	25	of	of	IN
cord-015021-pol2qm74	5730	26	skeletal	skeletal	JJ
cord-015021-pol2qm74	5730	27	muscle	muscle	NN
cord-015021-pol2qm74	5730	28	?	?	.
cord-015021-pol2qm74	5731	1	P.	P.	NNP
cord-015021-pol2qm74	5731	2	Boekstegers	Boekstegers	NNP
cord-015021-pol2qm74	5731	3	,	,	,
cord-015021-pol2qm74	5731	4	K.	K.	NNP
cord-015021-pol2qm74	5731	5	Werdan	Werdan	NNP
cord-015021-pol2qm74	5731	6	Department	Department	NNP
cord-015021-pol2qm74	5731	7	of	of	IN
cord-015021-pol2qm74	5731	8	Medicine	Medicine	NNP
cord-015021-pol2qm74	5732	1	I	-PRON-	PRP
cord-015021-pol2qm74	5732	2	,	,	,
cord-015021-pol2qm74	5732	3	Gro6hadern	Gro6hadern	NNP
cord-015021-pol2qm74	5732	4	University	University	NNP
cord-015021-pol2qm74	5732	5	Hospital	Hospital	NNP
cord-015021-pol2qm74	5732	6	,	,	,
cord-015021-pol2qm74	5732	7	Munich	Munich	NNP
cord-015021-pol2qm74	5732	8	,	,	,
cord-015021-pol2qm74	5732	9	Germany	Germany	NNP
cord-015021-pol2qm74	5733	1	A	a	DT
cord-015021-pol2qm74	5733	2	pathological	pathological	JJ
cord-015021-pol2qm74	5733	3	oxygen	oxygen	NN
cord-015021-pol2qm74	5733	4	uptake	uptake	NN
cord-015021-pol2qm74	5733	5	supply	supply	NN
cord-015021-pol2qm74	5733	6	dependence	dependence	NN
cord-015021-pol2qm74	5733	7	was	be	VBD
cord-015021-pol2qm74	5733	8	suggested	suggest	VBN
cord-015021-pol2qm74	5733	9	to	to	TO
cord-015021-pol2qm74	5733	10	indicate	indicate	VB
cord-015021-pol2qm74	5733	11	tissue	tissue	NN
cord-015021-pol2qm74	5733	12	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5733	13	in	in	IN
cord-015021-pol2qm74	5733	14	sepsis	sepsis	NN
cord-015021-pol2qm74	5733	15	-	-	:
cord-015021-pol2qm74	5733	16	a	a	DT
cord-015021-pol2qm74	5733	17	hypothesis	hypothesis	NN
cord-015021-pol2qm74	5733	18	which	which	WDT
cord-015021-pol2qm74	5733	19	is	be	VBZ
cord-015021-pol2qm74	5733	20	discussed	discuss	VBN
cord-015021-pol2qm74	5733	21	controversially	controversially	RB
cord-015021-pol2qm74	5733	22	.	.	.
cord-015021-pol2qm74	5734	1	Because	because	IN
cord-015021-pol2qm74	5734	2	the	the	DT
cord-015021-pol2qm74	5734	3	detection	detection	NN
cord-015021-pol2qm74	5734	4	of	of	IN
cord-015021-pol2qm74	5734	5	reduced	reduce	VBN
cord-015021-pol2qm74	5734	6	oxygen	oxygen	NN
cord-015021-pol2qm74	5734	7	transport	transport	NN
cord-015021-pol2qm74	5734	8	to	to	IN
cord-015021-pol2qm74	5734	9	tissue	tissue	NN
cord-015021-pol2qm74	5734	10	and	and	CC
cord-015021-pol2qm74	5734	11	&	&	CC
cord-015021-pol2qm74	5734	12	tissue	tissue	NN
cord-015021-pol2qm74	5734	13	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5734	14	would	would	MD
cord-015021-pol2qm74	5734	15	have	have	VB
cord-015021-pol2qm74	5734	16	important	important	JJ
cord-015021-pol2qm74	5734	17	implications	implication	NNS
cord-015021-pol2qm74	5734	18	for	for	IN
cord-015021-pol2qm74	5734	19	therapy	therapy	NN
cord-015021-pol2qm74	5734	20	,	,	,
cord-015021-pol2qm74	5734	21	skeletal	skeletal	JJ
cord-015021-pol2qm74	5734	22	muscle	muscle	NN
cord-015021-pol2qm74	5734	23	oxygenation	oxygenation	NN
cord-015021-pol2qm74	5734	24	was	be	VBD
cord-015021-pol2qm74	5734	25	studied	study	VBN
cord-015021-pol2qm74	5734	26	in	in	IN
cord-015021-pol2qm74	5734	27	patients	patient	NNS
cord-015021-pol2qm74	5734	28	with	with	IN
cord-015021-pol2qm74	5734	29	sepsis	sepsis	NN
cord-015021-pol2qm74	5734	30	.	.	.
cord-015021-pol2qm74	5735	1	Intermittent	intermittent	JJ
cord-015021-pol2qm74	5735	2	and	and	CC
cord-015021-pol2qm74	5735	3	continuous	continuous	JJ
cord-015021-pol2qm74	5735	4	determination	determination	NN
cord-015021-pol2qm74	5735	5	of	of	IN
cord-015021-pol2qm74	5735	6	skeletal	skeletal	JJ
cord-015021-pol2qm74	5735	7	muscle	muscle	NN
cord-015021-pol2qm74	5735	8	pO	po	NN
cord-015021-pol2qm74	5735	9	2	2	CD
cord-015021-pol2qm74	5735	10	by	by	IN
cord-015021-pol2qm74	5735	11	polarographic	polarographic	JJ
cord-015021-pol2qm74	5735	12	needle	needle	NN
cord-015021-pol2qm74	5735	13	or	or	CC
cord-015021-pol2qm74	5735	14	catheter	catheter	NN
cord-015021-pol2qm74	5735	15	probes	probe	NNS
cord-015021-pol2qm74	5735	16	provided	provide	VBD
cord-015021-pol2qm74	5735	17	no	no	DT
cord-015021-pol2qm74	5735	18	evidence	evidence	NN
cord-015021-pol2qm74	5735	19	for	for	IN
cord-015021-pol2qm74	5735	20	skeletal	skeletal	JJ
cord-015021-pol2qm74	5735	21	muscle	muscle	NN
cord-015021-pol2qm74	5735	22	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5735	23	even	even	RB
cord-015021-pol2qm74	5735	24	in	in	IN
cord-015021-pol2qm74	5735	25	severe	severe	JJ
cord-015021-pol2qm74	5735	26	stage	stage	NN
cord-015021-pol2qm74	5735	27	of	of	IN
cord-015021-pol2qm74	5735	28	sepsis	sepsis	NN
cord-015021-pol2qm74	5736	1	(	(	-LRB-
cord-015021-pol2qm74	5736	2	Boekstegers	Boekstegers	NNP
cord-015021-pol2qm74	5736	3	et	et	NNP
cord-015021-pol2qm74	5736	4	al	al	NNP
cord-015021-pol2qm74	5736	5	.	.	NNP
cord-015021-pol2qm74	5736	6	,	,	,
cord-015021-pol2qm74	5737	1	Crit	Crit	NNP
cord-015021-pol2qm74	5737	2	Care	Care	NNP
cord-015021-pol2qm74	5737	3	Med	Med	NNP
cord-015021-pol2qm74	5737	4	1994	1994	CD
cord-015021-pol2qm74	5737	5	)	)	-RRB-
cord-015021-pol2qm74	5737	6	.	.	.
cord-015021-pol2qm74	5738	1	In	in	IN
cord-015021-pol2qm74	5738	2	contrast	contrast	NN
cord-015021-pol2qm74	5738	3	,	,	,
cord-015021-pol2qm74	5738	4	mean	mean	JJ
cord-015021-pol2qm74	5738	5	skeletal	skeletal	JJ
cord-015021-pol2qm74	5738	6	muscle	muscle	NN
cord-015021-pol2qm74	5738	7	pO	po	NN
cord-015021-pol2qm74	5738	8	2	2	CD
cord-015021-pol2qm74	5738	9	was	be	VBD
cord-015021-pol2qm74	5738	10	found	find	VBN
cord-015021-pol2qm74	5738	11	to	to	TO
cord-015021-pol2qm74	5738	12	be	be	VB
cord-015021-pol2qm74	5738	13	abnormally	abnormally	RB
cord-015021-pol2qm74	5738	14	high	high	JJ
cord-015021-pol2qm74	5738	15	in	in	IN
cord-015021-pol2qm74	5738	16	patients	patient	NNS
cord-015021-pol2qm74	5738	17	with	with	IN
cord-015021-pol2qm74	5738	18	sepsis	sepsis	NN
cord-015021-pol2qm74	5738	19	(	(	-LRB-
cord-015021-pol2qm74	5738	20	48	48	CD
cord-015021-pol2qm74	5738	21	_	_	NN
cord-015021-pol2qm74	5738	22	+	+	CC
cord-015021-pol2qm74	5738	23	10,4	10,4	CD
cord-015021-pol2qm74	5738	24	mmHg	mmHg	NNS
cord-015021-pol2qm74	5738	25	,	,	,
cord-015021-pol2qm74	5738	26	n=39	n=39	NNP
cord-015021-pol2qm74	5738	27	)	)	-RRB-
cord-015021-pol2qm74	5738	28	compared	compare	VBN
cord-015021-pol2qm74	5738	29	to	to	IN
cord-015021-pol2qm74	5738	30	patients	patient	NNS
cord-015021-pol2qm74	5738	31	with	with	IN
cord-015021-pol2qm74	5738	32	limited	limited	JJ
cord-015021-pol2qm74	5738	33	infection	infection	NN
cord-015021-pol2qm74	5738	34	(	(	-LRB-
cord-015021-pol2qm74	5738	35	28	28	CD
cord-015021-pol2qm74	5738	36	,	,	,
cord-015021-pol2qm74	5738	37	4	4	CD
cord-015021-pol2qm74	5738	38	+	+	SYM
cord-015021-pol2qm74	5738	39	4	4	CD
cord-015021-pol2qm74	5738	40	,	,	,
cord-015021-pol2qm74	5738	41	7	7	CD
cord-015021-pol2qm74	5738	42	mmHg	mmHg	NNS
cord-015021-pol2qm74	5738	43	,	,	,
cord-015021-pol2qm74	5738	44	p<0.001	p<0.001	CD
cord-015021-pol2qm74	5738	45	,	,	,
cord-015021-pol2qm74	5738	46	n=16	n=16	NNP
cord-015021-pol2qm74	5738	47	)	)	-RRB-
cord-015021-pol2qm74	5738	48	,	,	,
cord-015021-pol2qm74	5738	49	to	to	IN
cord-015021-pol2qm74	5738	50	patients	patient	NNS
cord-015021-pol2qm74	5738	51	with	with	IN
cord-015021-pol2qm74	5738	52	cardiogenic	cardiogenic	JJ
cord-015021-pol2qm74	5738	53	shock	shock	NN
cord-015021-pol2qm74	5738	54	(	(	-LRB-
cord-015021-pol2qm74	5738	55	22,3	22,3	CD
cord-015021-pol2qm74	5738	56	+	+	SYM
cord-015021-pol2qm74	5738	57	6,2	6,2	CD
cord-015021-pol2qm74	5738	58	mmHg	mmHg	NNS
cord-015021-pol2qm74	5738	59	,	,	,
cord-015021-pol2qm74	5738	60	p<0.001	p<0.001	CD
cord-015021-pol2qm74	5738	61	,	,	,
cord-015021-pol2qm74	5738	62	n	n	NN
cord-015021-pol2qm74	5738	63	=	=	NN
cord-015021-pol2qm74	5738	64	lS	ls	NN
cord-015021-pol2qm74	5738	65	)	)	-RRB-
cord-015021-pol2qm74	5738	66	and	and	CC
cord-015021-pol2qm74	5738	67	to	to	IN
cord-015021-pol2qm74	5738	68	healthy	healthy	JJ
cord-015021-pol2qm74	5738	69	subjects	subject	NNS
cord-015021-pol2qm74	5738	70	(	(	-LRB-
cord-015021-pol2qm74	5738	71	33,3	33,3	CD
cord-015021-pol2qm74	5738	72	_	_	NN
cord-015021-pol2qm74	5738	73	+	+	CC
cord-015021-pol2qm74	5738	74	8,1	8,1	CD
cord-015021-pol2qm74	5738	75	mmHg	mmHg	NNS
cord-015021-pol2qm74	5738	76	,	,	,
cord-015021-pol2qm74	5738	77	p<0.001	p<0.001	CD
cord-015021-pol2qm74	5738	78	,	,	,
cord-015021-pol2qm74	5738	79	n=10	n=10	NNP
cord-015021-pol2qm74	5738	80	)	)	-RRB-
cord-015021-pol2qm74	5738	81	.	.	.
cord-015021-pol2qm74	5739	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	5739	2	,	,	,
cord-015021-pol2qm74	5739	3	serial	serial	JJ
cord-015021-pol2qm74	5739	4	measurements	measurement	NNS
cord-015021-pol2qm74	5739	5	in	in	IN
cord-015021-pol2qm74	5739	6	patients	patient	NNS
cord-015021-pol2qm74	5739	7	with	with	IN
cord-015021-pol2qm74	5739	8	sepsis	sepsis	NN
cord-015021-pol2qm74	5739	9	showed	show	VBD
cord-015021-pol2qm74	5739	10	that	that	IN
cord-015021-pol2qm74	5739	11	skeletal	skeletal	JJ
cord-015021-pol2qm74	5739	12	muscle	muscle	NN
cord-015021-pol2qm74	5739	13	pO	po	NN
cord-015021-pol2qm74	5739	14	2	2	CD
cord-015021-pol2qm74	5739	15	was	be	VBD
cord-015021-pol2qm74	5739	16	higher	high	JJR
cord-015021-pol2qm74	5740	1	(	(	-LRB-
cord-015021-pol2qm74	5740	2	44,1	44,1	CD
cord-015021-pol2qm74	5740	3	_	_	NN
cord-015021-pol2qm74	5740	4	+	+	SYM
cord-015021-pol2qm74	5740	5	10,3	10,3	CD
cord-015021-pol2qm74	5740	6	mmHg	mmHg	NNS
cord-015021-pol2qm74	5740	7	)	)	-RRB-
cord-015021-pol2qm74	5740	8	on	on	IN
cord-015021-pol2qm74	5740	9	days	day	NNS
cord-015021-pol2qm74	5740	10	with	with	IN
cord-015021-pol2qm74	5740	11	severe	severe	JJ
cord-015021-pol2qm74	5740	12	sepsis	sepsis	NN
cord-015021-pol2qm74	5741	1	than	than	IN
cord-015021-pol2qm74	5741	2	on	on	IN
cord-015021-pol2qm74	5741	3	days	day	NNS
cord-015021-pol2qm74	5741	4	with	with	IN
cord-015021-pol2qm74	5741	5	intermediate	intermediate	JJ
cord-015021-pol2qm74	5741	6	state	state	NN
cord-015021-pol2qm74	5741	7	(	(	-LRB-
cord-015021-pol2qm74	5741	8	30,1	30,1	CD
cord-015021-pol2qm74	5741	9	_	_	NN
cord-015021-pol2qm74	5741	10	+	+	SYM
cord-015021-pol2qm74	5741	11	8	8	CD
cord-015021-pol2qm74	5741	12	mmHg	mmHg	NNS
cord-015021-pol2qm74	5741	13	)	)	-RRB-
cord-015021-pol2qm74	5741	14	and	and	CC
cord-015021-pol2qm74	5741	15	than	than	IN
cord-015021-pol2qm74	5741	16	on	on	IN
cord-015021-pol2qm74	5741	17	days	day	NNS
cord-015021-pol2qm74	5741	18	without	without	IN
cord-015021-pol2qm74	5741	19	sepsis	sepsis	NN
cord-015021-pol2qm74	5741	20	(	(	-LRB-
cord-015021-pol2qm74	5741	21	26	26	CD
cord-015021-pol2qm74	5741	22	,	,	,
cord-015021-pol2qm74	5741	23	8	8	CD
cord-015021-pol2qm74	5741	24	_	_	NN
cord-015021-pol2qm74	5741	25	+	+	SYM
cord-015021-pol2qm74	5741	26	5	5	CD
cord-015021-pol2qm74	5741	27	,	,	,
cord-015021-pol2qm74	5741	28	I	-PRON-	PRP
cord-015021-pol2qm74	5741	29	mmHg	mmHg	NNP
cord-015021-pol2qm74	5741	30	)	)	-RRB-
cord-015021-pol2qm74	5741	31	.	.	.
cord-015021-pol2qm74	5742	1	Thus	thus	RB
cord-015021-pol2qm74	5742	2	,	,	,
cord-015021-pol2qm74	5742	3	a	a	DT
cord-015021-pol2qm74	5742	4	decrease	decrease	NN
cord-015021-pol2qm74	5742	5	of	of	IN
cord-015021-pol2qm74	5742	6	abnormally	abnormally	RB
cord-015021-pol2qm74	5742	7	high	high	JJ
cord-015021-pol2qm74	5742	8	skeletal	skeletal	JJ
cord-015021-pol2qm74	5742	9	muscle	muscle	NN
cord-015021-pol2qm74	5742	10	pO	po	NN
cord-015021-pol2qm74	5742	11	2	2	CD
cord-015021-pol2qm74	5742	12	was	be	VBD
cord-015021-pol2qm74	5742	13	related	relate	VBN
cord-015021-pol2qm74	5742	14	to	to	IN
cord-015021-pol2qm74	5742	15	improvement	improvement	NN
cord-015021-pol2qm74	5742	16	of	of	IN
cord-015021-pol2qm74	5742	17	sepsis	sepsis	NN
cord-015021-pol2qm74	5742	18	.	.	.
cord-015021-pol2qm74	5743	1	This	this	DT
cord-015021-pol2qm74	5743	2	was	be	VBD
cord-015021-pol2qm74	5743	3	also	also	RB
cord-015021-pol2qm74	5743	4	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	5743	5	by	by	IN
cord-015021-pol2qm74	5743	6	comparing	compare	VBG
cord-015021-pol2qm74	5743	7	the	the	DT
cord-015021-pol2qm74	5743	8	decrease	decrease	NN
cord-015021-pol2qm74	5743	9	of	of	IN
cord-015021-pol2qm74	5743	10	abnormally	abnormally	RB
cord-015021-pol2qm74	5743	11	high	high	JJ
cord-015021-pol2qm74	5743	12	skeletal	skeletal	JJ
cord-015021-pol2qm74	5743	13	muscle	muscle	NN
cord-015021-pol2qm74	5743	14	pO	po	NN
cord-015021-pol2qm74	5743	15	2	2	CD
cord-015021-pol2qm74	5743	16	with	with	IN
cord-015021-pol2qm74	5743	17	the	the	DT
cord-015021-pol2qm74	5743	18	decrease	decrease	NN
cord-015021-pol2qm74	5743	19	of	of	IN
cord-015021-pol2qm74	5743	20	APACHE	APACHE	NNP
cord-015021-pol2qm74	5743	21	II	II	NNP
cord-015021-pol2qm74	5743	22	score	score	NN
cord-015021-pol2qm74	5743	23	or	or	CC
cord-015021-pol2qm74	5743	24	Elebute	Elebute	NNP
cord-015021-pol2qm74	5743	25	score	score	NN
cord-015021-pol2qm74	5743	26	as	as	RB
cord-015021-pol2qm74	5743	27	well	well	RB
cord-015021-pol2qm74	5743	28	as	as	IN
cord-015021-pol2qm74	5743	29	Interleukin-6	Interleukin-6	NNP
cord-015021-pol2qm74	5743	30	serum	serum	NN
cord-015021-pol2qm74	5743	31	levels	level	NNS
cord-015021-pol2qm74	5743	32	in	in	IN
cord-015021-pol2qm74	5743	33	a	a	DT
cord-015021-pol2qm74	5743	34	separate	separate	JJ
cord-015021-pol2qm74	5743	35	study	study	NN
cord-015021-pol2qm74	5743	36	(	(	-LRB-
cord-015021-pol2qm74	5743	37	Boekstegers	Boekstegers	NNP
cord-015021-pol2qm74	5743	38	et	et	NNP
cord-015021-pol2qm74	5743	39	el	el	NNP
cord-015021-pol2qm74	5743	40	.	.	NNP
cord-015021-pol2qm74	5743	41	,	,	,
cord-015021-pol2qm74	5743	42	Shock	Shock	NNP
cord-015021-pol2qm74	5743	43	,	,	,
cord-015021-pol2qm74	5743	44	in	in	IN
cord-015021-pol2qm74	5743	45	press	press	NN
cord-015021-pol2qm74	5743	46	)	)	-RRB-
cord-015021-pol2qm74	5743	47	.	.	.
cord-015021-pol2qm74	5744	1	In	in	IN
cord-015021-pol2qm74	5744	2	summary	summary	NN
cord-015021-pol2qm74	5744	3	,	,	,
cord-015021-pol2qm74	5744	4	our	-PRON-	PRP$
cord-015021-pol2qm74	5744	5	data	datum	NNS
cord-015021-pol2qm74	5744	6	provide	provide	VBP
cord-015021-pol2qm74	5744	7	no	no	DT
cord-015021-pol2qm74	5744	8	evidence	evidence	NN
cord-015021-pol2qm74	5744	9	for	for	IN
cord-015021-pol2qm74	5744	10	skeletal	skeletal	JJ
cord-015021-pol2qm74	5744	11	muscle	muscle	NN
cord-015021-pol2qm74	5744	12	hypoxia	hypoxia	NN
cord-015021-pol2qm74	5744	13	in	in	IN
cord-015021-pol2qm74	5744	14	patients	patient	NNS
cord-015021-pol2qm74	5744	15	with	with	IN
cord-015021-pol2qm74	5744	16	sepsis	sepsis	NN
cord-015021-pol2qm74	5744	17	but	but	CC
cord-015021-pol2qm74	5744	18	support	support	VBP
cord-015021-pol2qm74	5744	19	the	the	DT
cord-015021-pol2qm74	5744	20	assumption	assumption	NN
cord-015021-pol2qm74	5744	21	&	&	CC
cord-015021-pol2qm74	5744	22	impaired	impair	VBN
cord-015021-pol2qm74	5744	23	oxygen	oxygen	NN
cord-015021-pol2qm74	5744	24	metabolism	metabolism	NN
cord-015021-pol2qm74	5744	25	in	in	IN
cord-015021-pol2qm74	5744	26	severe	severe	JJ
cord-015021-pol2qm74	5744	27	sepsis	sepsis	NN
cord-015021-pol2qm74	5744	28	.	.	.
cord-015021-pol2qm74	5745	1	NeutropNlic	NeutropNlic	NNP
cord-015021-pol2qm74	5745	2	emigration	emigration	NN
cord-015021-pol2qm74	5745	3	from	from	IN
cord-015021-pol2qm74	5745	4	the	the	DT
cord-015021-pol2qm74	5745	5	vascular	vascular	JJ
cord-015021-pol2qm74	5745	6	space	space	NN
cord-015021-pol2qm74	5745	7	into	into	IN
cord-015021-pol2qm74	5745	8	the	the	DT
cord-015021-pol2qm74	5745	9	extracellular	extracellular	JJ
cord-015021-pol2qm74	5745	10	matrix	matrix	NN
cord-015021-pol2qm74	5745	11	is	be	VBZ
cord-015021-pol2qm74	5745	12	important	important	JJ
cord-015021-pol2qm74	5745	13	for	for	IN
cord-015021-pol2qm74	5745	14	the	the	DT
cord-015021-pol2qm74	5745	15	response	response	NN
cord-015021-pol2qm74	5745	16	to	to	TO
cord-015021-pol2qm74	5745	17	tissue	tissue	NN
cord-015021-pol2qm74	5745	18	injury	injury	NN
cord-015021-pol2qm74	5745	19	or	or	CC
cord-015021-pol2qm74	5745	20	contamination	contamination	NN
cord-015021-pol2qm74	5745	21	by	by	IN
cord-015021-pol2qm74	5745	22	providing	provide	VBG
cord-015021-pol2qm74	5745	23	a	a	DT
cord-015021-pol2qm74	5745	24	large	large	JJ
cord-015021-pol2qm74	5745	25	recruitable	recruitable	JJ
cord-015021-pol2qm74	5745	26	pool	pool	NN
cord-015021-pol2qm74	5745	27	of	of	IN
cord-015021-pol2qm74	5745	28	tissue	tissue	NN
cord-015021-pol2qm74	5745	29	-	-	HYPH
cord-015021-pol2qm74	5745	30	based	base	VBN
cord-015021-pol2qm74	5745	31	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	5745	32	.	.	.
cord-015021-pol2qm74	5746	1	The	the	DT
cord-015021-pol2qm74	5746	2	consequences	consequence	NNS
cord-015021-pol2qm74	5746	3	of	of	IN
cord-015021-pol2qm74	5746	4	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5746	5	exposure	exposure	NN
cord-015021-pol2qm74	5746	6	to	to	IN
cord-015021-pol2qm74	5746	7	intravaseular	intravaseular	NNP
cord-015021-pol2qm74	5746	8	chemoattractants	chemoattractants	NNP
cord-015021-pol2qm74	5746	9	,	,	,
cord-015021-pol2qm74	5746	10	likely	likely	RB
cord-015021-pol2qm74	5746	11	relevant	relevant	JJ
cord-015021-pol2qm74	5746	12	for	for	IN
cord-015021-pol2qm74	5746	13	IL-8	IL-8	NNP
cord-015021-pol2qm74	5746	14	and	and	CC
cord-015021-pol2qm74	5746	15	C5a	C5a	NNS
cord-015021-pol2qm74	5746	16	in	in	IN
cord-015021-pol2qm74	5746	17	sepsis	sepsis	NN
cord-015021-pol2qm74	5746	18	,	,	,
cord-015021-pol2qm74	5746	19	trauma	trauma	NN
cord-015021-pol2qm74	5746	20	,	,	,
cord-015021-pol2qm74	5746	21	and	and	CC
cord-015021-pol2qm74	5746	22	in	in	IN
cord-015021-pol2qm74	5746	23	burn	burn	NN
cord-015021-pol2qm74	5746	24	injury	injury	NN
cord-015021-pol2qm74	5746	25	,	,	,
cord-015021-pol2qm74	5746	26	are	be	VBP
cord-015021-pol2qm74	5746	27	suppression	suppression	NN
cord-015021-pol2qm74	5746	28	of	of	IN
cord-015021-pol2qm74	5746	29	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5746	30	attachment	attachment	NN
cord-015021-pol2qm74	5746	31	to	to	IN
cord-015021-pol2qm74	5746	32	endothelial	endothelial	JJ
cord-015021-pol2qm74	5746	33	cells	cell	NNS
cord-015021-pol2qm74	5746	34	and	and	CC
cord-015021-pol2qm74	5746	35	matrix	matrix	NN
cord-015021-pol2qm74	5746	36	proteins	protein	NNS
cord-015021-pol2qm74	5746	37	.	.	.
cord-015021-pol2qm74	5747	1	It	-PRON-	PRP
cord-015021-pol2qm74	5747	2	is	be	VBZ
cord-015021-pol2qm74	5747	3	probable	probable	JJ
cord-015021-pol2qm74	5747	4	that	that	IN
cord-015021-pol2qm74	5747	5	proteoglycan	proteoglycan	NN
cord-015021-pol2qm74	5747	6	-	-	HYPH
cord-015021-pol2qm74	5747	7	bound	bind	VBN
cord-015021-pol2qm74	5747	8	attractants	attractant	NNS
cord-015021-pol2qm74	5747	9	are	be	VBP
cord-015021-pol2qm74	5747	10	of	of	IN
cord-015021-pol2qm74	5747	11	considerable	considerable	JJ
cord-015021-pol2qm74	5747	12	biologic	biologic	JJ
cord-015021-pol2qm74	5747	13	relevance	relevance	NN
cord-015021-pol2qm74	5747	14	,	,	,
cord-015021-pol2qm74	5747	15	and	and	CC
cord-015021-pol2qm74	5747	16	may	may	MD
cord-015021-pol2qm74	5747	17	result	result	VB
cord-015021-pol2qm74	5747	18	in	in	IN
cord-015021-pol2qm74	5747	19	enhancement	enhancement	NN
cord-015021-pol2qm74	5747	20	of	of	IN
cord-015021-pol2qm74	5747	21	responses	response	NNS
cord-015021-pol2qm74	5747	22	to	to	TO
cord-015021-pol2qm74	5747	23	subsequently	subsequently	RB
cord-015021-pol2qm74	5747	24	encountered	encounter	VBD
cord-015021-pol2qm74	5747	25	cytokines	cytokine	NNS
cord-015021-pol2qm74	5747	26	.	.	.
cord-015021-pol2qm74	5748	1	In	in	IN
cord-015021-pol2qm74	5748	2	the	the	DT
cord-015021-pol2qm74	5748	3	presence	presence	NN
cord-015021-pol2qm74	5748	4	of	of	IN
cord-015021-pol2qm74	5748	5	connective	connective	JJ
cord-015021-pol2qm74	5748	6	tissue	tissue	NN
cord-015021-pol2qm74	5748	7	proteins	protein	NNS
cord-015021-pol2qm74	5748	8	expressing	express	VBG
cord-015021-pol2qm74	5748	9	integrin	integrin	NN
cord-015021-pol2qm74	5748	10	-	-	HYPH
cord-015021-pol2qm74	5748	11	specific	specific	JJ
cord-015021-pol2qm74	5748	12	binding	bind	VBG
cord-015021-pol2qm74	5748	13	ligands	ligand	NNS
cord-015021-pol2qm74	5748	14	,	,	,
cord-015021-pol2qm74	5748	15	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	5748	16	respond	respond	VBP
cord-015021-pol2qm74	5748	17	to	to	IN
cord-015021-pol2qm74	5748	18	TNF	TNF	NNP
cord-015021-pol2qm74	5748	19	-	-	HYPH
cord-015021-pol2qm74	5748	20	cq	cq	NNP
cord-015021-pol2qm74	5748	21	GM	GM	NNP
cord-015021-pol2qm74	5748	22	-	-	HYPH
cord-015021-pol2qm74	5748	23	CSF	CSF	NNP
cord-015021-pol2qm74	5748	24	and	and	CC
cord-015021-pol2qm74	5748	25	other	other	JJ
cord-015021-pol2qm74	5748	26	cytokines	cytokine	NNS
cord-015021-pol2qm74	5748	27	by	by	IN
cord-015021-pol2qm74	5748	28	producing	produce	VBG
cord-015021-pol2qm74	5748	29	large	large	JJ
cord-015021-pol2qm74	5748	30	amounts	amount	NNS
cord-015021-pol2qm74	5748	31	of	of	IN
cord-015021-pol2qm74	5748	32	hydrogen	hydrogen	NN
cord-015021-pol2qm74	5748	33	peroxide	peroxide	NN
cord-015021-pol2qm74	5748	34	.	.	.
cord-015021-pol2qm74	5749	1	This	this	DT
cord-015021-pol2qm74	5749	2	response	response	NN
cord-015021-pol2qm74	5749	3	is	be	VBZ
cord-015021-pol2qm74	5749	4	likely	likely	RB
cord-015021-pol2qm74	5749	5	important	important	JJ
cord-015021-pol2qm74	5749	6	in	in	IN
cord-015021-pol2qm74	5749	7	the	the	DT
cord-015021-pol2qm74	5749	8	digestion	digestion	NN
cord-015021-pol2qm74	5749	9	of	of	IN
cord-015021-pol2qm74	5749	10	contaminated	contaminate	VBN
cord-015021-pol2qm74	5749	11	or	or	CC
cord-015021-pol2qm74	5749	12	injured	injure	VBN
cord-015021-pol2qm74	5749	13	tissue	tissue	NN
cord-015021-pol2qm74	5749	14	by	by	IN
cord-015021-pol2qm74	5749	15	facilitating	facilitate	VBG
cord-015021-pol2qm74	5749	16	activity	activity	NN
cord-015021-pol2qm74	5749	17	of	of	IN
cord-015021-pol2qm74	5749	18	neutrnphil	neutrnphil	NNP
cord-015021-pol2qm74	5749	19	granular	granular	JJ
cord-015021-pol2qm74	5749	20	proteases	protease	NNS
cord-015021-pol2qm74	5749	21	and	and	CC
cord-015021-pol2qm74	5749	22	inactivating	inactivate	VBG
cord-015021-pol2qm74	5749	23	plasma	plasma	NN
cord-015021-pol2qm74	5749	24	anti	anti	NNS
cord-015021-pol2qm74	5749	25	-	-	NNS
cord-015021-pol2qm74	5749	26	proteases	protease	NNS
cord-015021-pol2qm74	5749	27	.	.	.
cord-015021-pol2qm74	5750	1	This	this	DT
cord-015021-pol2qm74	5750	2	matrix	matrix	NN
cord-015021-pol2qm74	5750	3	-	-	HYPH
cord-015021-pol2qm74	5750	4	dependent	dependent	JJ
cord-015021-pol2qm74	5750	5	oxidative	oxidative	JJ
cord-015021-pol2qm74	5750	6	response	response	NN
cord-015021-pol2qm74	5750	7	is	be	VBZ
cord-015021-pol2qm74	5750	8	important	important	JJ
cord-015021-pol2qm74	5750	9	in	in	IN
cord-015021-pol2qm74	5750	10	defining	define	VBG
cord-015021-pol2qm74	5750	11	potential	potential	JJ
cord-015021-pol2qm74	5750	12	novel	novel	NN
cord-015021-pol2qm74	5750	13	targets	target	NNS
cord-015021-pol2qm74	5750	14	for	for	IN
cord-015021-pol2qm74	5750	15	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	5750	16	intervention	intervention	NN
cord-015021-pol2qm74	5750	17	.	.	.
cord-015021-pol2qm74	5751	1	The	the	DT
cord-015021-pol2qm74	5751	2	response	response	NN
cord-015021-pol2qm74	5751	3	appears	appear	VBZ
cord-015021-pol2qm74	5751	4	to	to	TO
cord-015021-pol2qm74	5751	5	involve	involve	VB
cord-015021-pol2qm74	5751	6	signalling	signal	VBG
cord-015021-pol2qm74	5751	7	by	by	IN
cord-015021-pol2qm74	5751	8	integrin	integrin	NN
cord-015021-pol2qm74	5751	9	-	-	HYPH
cord-015021-pol2qm74	5751	10	linked	link	VBN
cord-015021-pol2qm74	5751	11	tyrosine	tyrosine	NN
cord-015021-pol2qm74	5751	12	kinases	kinase	NNS
cord-015021-pol2qm74	5751	13	.	.	.
cord-015021-pol2qm74	5752	1	The	the	DT
cord-015021-pol2qm74	5752	2	net	net	JJ
cord-015021-pol2qm74	5752	3	effect	effect	NN
cord-015021-pol2qm74	5752	4	of	of	IN
cord-015021-pol2qm74	5752	5	matrix	matrix	NN
cord-015021-pol2qm74	5752	6	protein	protein	NN
cord-015021-pol2qm74	5752	7	injury	injury	NN
cord-015021-pol2qm74	5752	8	through	through	IN
cord-015021-pol2qm74	5752	9	this	this	DT
cord-015021-pol2qm74	5752	10	mechanism	mechanism	NN
cord-015021-pol2qm74	5752	11	is	be	VBZ
cord-015021-pol2qm74	5752	12	enhancement	enhancement	NN
cord-015021-pol2qm74	5752	13	of	of	IN
cord-015021-pol2qm74	5752	14	the	the	DT
cord-015021-pol2qm74	5752	15	fibrotic	fibrotic	JJ
cord-015021-pol2qm74	5752	16	response	response	NN
cord-015021-pol2qm74	5752	17	which	which	WDT
cord-015021-pol2qm74	5752	18	underlies	underlie	VBZ
cord-015021-pol2qm74	5752	19	much	much	JJ
cord-015021-pol2qm74	5752	20	of	of	IN
cord-015021-pol2qm74	5752	21	the	the	DT
cord-015021-pol2qm74	5752	22	prolonged	prolong	VBN
cord-015021-pol2qm74	5752	23	ventilator	ventilator	NN
cord-015021-pol2qm74	5752	24	dependence	dependence	NN
cord-015021-pol2qm74	5752	25	of	of	IN
cord-015021-pol2qm74	5752	26	patients	patient	NNS
cord-015021-pol2qm74	5752	27	with	with	IN
cord-015021-pol2qm74	5752	28	the	the	DT
cord-015021-pol2qm74	5752	29	adult	adult	NN
cord-015021-pol2qm74	5752	30	respiratory	respiratory	JJ
cord-015021-pol2qm74	5752	31	distress	distress	NN
cord-015021-pol2qm74	5752	32	syndrome	syndrome	NN
cord-015021-pol2qm74	5752	33	.	.	.
cord-015021-pol2qm74	5753	1	This	this	DT
cord-015021-pol2qm74	5753	2	adherence	adherence	NN
cord-015021-pol2qm74	5753	3	dependent	dependent	JJ
cord-015021-pol2qm74	5753	4	response	response	NN
cord-015021-pol2qm74	5753	5	has	have	VBZ
cord-015021-pol2qm74	5753	6	also	also	RB
cord-015021-pol2qm74	5753	7	been	be	VBN
cord-015021-pol2qm74	5753	8	implicated	implicate	VBN
cord-015021-pol2qm74	5753	9	in	in	IN
cord-015021-pol2qm74	5753	10	direct	direct	JJ
cord-015021-pol2qm74	5753	11	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	5753	12	injury	injury	NN
cord-015021-pol2qm74	5753	13	,	,	,
cord-015021-pol2qm74	5753	14	and	and	CC
cord-015021-pol2qm74	5753	15	may	may	MD
cord-015021-pol2qm74	5753	16	represent	represent	VB
cord-015021-pol2qm74	5753	17	an	an	DT
cord-015021-pol2qm74	5753	18	early	early	JJ
cord-015021-pol2qm74	5753	19	component	component	NN
cord-015021-pol2qm74	5753	20	of	of	IN
cord-015021-pol2qm74	5753	21	the	the	DT
cord-015021-pol2qm74	5753	22	syndrome	syndrome	NN
cord-015021-pol2qm74	5753	23	of	of	IN
cord-015021-pol2qm74	5753	24	multisystem	multisystem	JJ
cord-015021-pol2qm74	5753	25	organ	organ	NN
cord-015021-pol2qm74	5753	26	failure	failure	NN
cord-015021-pol2qm74	5753	27	.	.	.
cord-015021-pol2qm74	5754	1	Study	study	NN
cord-015021-pol2qm74	5754	2	purpose	purpose	NN
cord-015021-pol2qm74	5754	3	:	:	:
cord-015021-pol2qm74	5754	4	In	in	IN
cord-015021-pol2qm74	5754	5	this	this	DT
cord-015021-pol2qm74	5754	6	patient	patient	NN
cord-015021-pol2qm74	5754	7	(	(	-LRB-
cord-015021-pol2qm74	5754	8	pat	pat	NNP
cord-015021-pol2qm74	5754	9	.	.	.
cord-015021-pol2qm74	5754	10	)	)	-RRB-
cord-015021-pol2qm74	5754	11	population	population	NN
cord-015021-pol2qm74	5754	12	with	with	IN
cord-015021-pol2qm74	5754	13	a	a	DT
cord-015021-pol2qm74	5754	14	considerable	considerable	JJ
cord-015021-pol2qm74	5754	15	sepsis	sepsis	NN
cord-015021-pol2qm74	5754	16	morbidity	morbidity	NN
cord-015021-pol2qm74	5754	17	and	and	CC
cord-015021-pol2qm74	5754	18	mortality	mortality	NN
cord-015021-pol2qm74	5754	19	,	,	,
cord-015021-pol2qm74	5754	20	parameters	parameter	NNS
cord-015021-pol2qm74	5754	21	proposed	propose	VBN
cord-015021-pol2qm74	5754	22	for	for	IN
cord-015021-pol2qm74	5754	23	sepsis	sepsis	NN
cord-015021-pol2qm74	5754	24	assessment	assessment	NN
cord-015021-pol2qm74	5754	25	(	(	-LRB-
cord-015021-pol2qm74	5754	26	Elebute	elebute	NN
cord-015021-pol2qm74	5754	27	sepsis	sepsis	NN
cord-015021-pol2qm74	5754	28	score	score	NN
cord-015021-pol2qm74	5754	29	[	[	-LRB-
cord-015021-pol2qm74	5754	30	Ele	Ele	NNP
cord-015021-pol2qm74	5754	31	]	]	-RRB-
cord-015021-pol2qm74	5754	32	,	,	,
cord-015021-pol2qm74	5754	33	SIRS	SIRS	NNP
cord-015021-pol2qm74	5754	34	)	)	-RRB-
cord-015021-pol2qm74	5754	35	were	be	VBD
cord-015021-pol2qm74	5754	36	investigated	investigate	VBN
cord-015021-pol2qm74	5754	37	with	with	IN
cord-015021-pol2qm74	5754	38	regard	regard	NN
cord-015021-pol2qm74	5754	39	to	to	IN
cord-015021-pol2qm74	5754	40	their	-PRON-	PRP$
cord-015021-pol2qm74	5754	41	use	use	NN
cord-015021-pol2qm74	5754	42	in	in	IN
cord-015021-pol2qm74	5754	43	the	the	DT
cord-015021-pol2qm74	5754	44	early	early	JJ
cord-015021-pol2qm74	5754	45	classification	classification	NN
cord-015021-pol2qm74	5754	46	of	of	IN
cord-015021-pol2qm74	5754	47	pop	pop	NN
cord-015021-pol2qm74	5754	48	.	.	.
cord-015021-pol2qm74	5755	1	pat	pat	NNP
cord-015021-pol2qm74	5755	2	.	.	.
cord-015021-pol2qm74	5756	1	at	at	IN
cord-015021-pol2qm74	5756	2	risk	risk	NN
cord-015021-pol2qm74	5756	3	for	for	IN
cord-015021-pol2qm74	5756	4	developing	develop	VBG
cord-015021-pol2qm74	5756	5	sepsis	sepsis	NN
cord-015021-pol2qm74	5756	6	.	.	.
cord-015021-pol2qm74	5757	1	Patients	patient	NNS
cord-015021-pol2qm74	5757	2	and	and	CC
cord-015021-pol2qm74	5757	3	Methods	method	NNS
cord-015021-pol2qm74	5757	4	:	:	:
cord-015021-pol2qm74	5757	5	In	in	IN
cord-015021-pol2qm74	5757	6	a	a	DT
cord-015021-pol2qm74	5757	7	previous	previous	JJ
cord-015021-pol2qm74	5757	8	observational	observational	JJ
cord-015021-pol2qm74	5757	9	study	study	NN
cord-015021-pol2qm74	5757	10	on	on	IN
cord-015021-pol2qm74	5757	11	110	110	CD
cord-015021-pol2qm74	5757	12	consecutive	consecutive	JJ
cord-015021-pol2qm74	5757	13	pat	pat	NN
cord-015021-pol2qm74	5757	14	.	.	.
cord-015021-pol2qm74	5758	1	after	after	IN
cord-015021-pol2qm74	5758	2	elective	elective	JJ
cord-015021-pol2qm74	5758	3	open	open	JJ
cord-015021-pol2qm74	5758	4	-	-	HYPH
cord-015021-pol2qm74	5758	5	heart	heart	NN
cord-015021-pol2qm74	5758	6	surgery	surgery	NN
cord-015021-pol2qm74	5758	7	,	,	,
cord-015021-pol2qm74	5758	8	we	-PRON-	PRP
cord-015021-pol2qm74	5758	9	had	have	VBD
cord-015021-pol2qm74	5758	10	determined	determine	VBN
cord-015021-pol2qm74	5758	11	Ele	Ele	NNP
cord-015021-pol2qm74	5758	12	daily	daily	RB
cord-015021-pol2qm74	5758	13	for	for	IN
cord-015021-pol2qm74	5758	14	at	at	RB
cord-015021-pol2qm74	5758	15	least	least	JJS
cord-015021-pol2qm74	5758	16	3	3	CD
cord-015021-pol2qm74	5758	17	pop	pop	NN
cord-015021-pol2qm74	5758	18	.	.	.
cord-015021-pol2qm74	5759	1	days	day	NNS
cord-015021-pol2qm74	5759	2	(	(	-LRB-
cord-015021-pol2qm74	5759	3	in	in	IN
cord-015021-pol2qm74	5759	4	pat	pat	NNP
cord-015021-pol2qm74	5759	5	.	.	.
cord-015021-pol2qm74	5760	1	with	with	IN
cord-015021-pol2qm74	5760	2	a	a	DT
cord-015021-pol2qm74	5760	3	longer	long	RBR
cord-015021-pol2qm74	5760	4	stay	stay	NN
cord-015021-pol2qm74	5760	5	:	:	:
cord-015021-pol2qm74	5760	6	until	until	IN
cord-015021-pol2qm74	5760	7	ICU	ICU	NNP
cord-015021-pol2qm74	5760	8	discharge	discharge	NN
cord-015021-pol2qm74	5760	9	)	)	-RRB-
cord-015021-pol2qm74	5760	10	.	.	.
cord-015021-pol2qm74	5761	1	After	after	IN
cord-015021-pol2qm74	5761	2	publication	publication	NN
cord-015021-pol2qm74	5761	3	of	of	IN
cord-015021-pol2qm74	5761	4	the	the	DT
cord-015021-pol2qm74	5761	5	newly	newly	RB
cord-015021-pol2qm74	5761	6	proposed	propose	VBN
cord-015021-pol2qm74	5761	7	SIRS	sirs	NN
cord-015021-pol2qm74	5761	8	definition	definition	NN
cord-015021-pol2qm74	5761	9	,	,	,
cord-015021-pol2qm74	5761	10	these	these	DT
cord-015021-pol2qm74	5761	11	criteria	criterion	NNS
cord-015021-pol2qm74	5761	12	were	be	VBD
cord-015021-pol2qm74	5761	13	retrospectively	retrospectively	RB
cord-015021-pol2qm74	5761	14	calculated	calculate	VBN
cord-015021-pol2qm74	5761	15	and	and	CC
cord-015021-pol2qm74	5761	16	compared	compare	VBN
cord-015021-pol2qm74	5761	17	to	to	IN
cord-015021-pol2qm74	5761	18	Ele	Ele	NNP
cord-015021-pol2qm74	5761	19	.	.	.
cord-015021-pol2qm74	5762	1	Results	result	NNS
cord-015021-pol2qm74	5762	2	:	:	:
cord-015021-pol2qm74	5763	1	On	on	IN
cord-015021-pol2qm74	5763	2	the	the	DT
cord-015021-pol2qm74	5763	3	total	total	NN
cord-015021-pol2qm74	5763	4	of	of	IN
cord-015021-pol2qm74	5763	5	n	n	NN
cord-015021-pol2qm74	5763	6	=	=	SYM
cord-015021-pol2qm74	5763	7	515	515	CD
cord-015021-pol2qm74	5763	8	patient	patient	NN
cord-015021-pol2qm74	5763	9	-	-	HYPH
cord-015021-pol2qm74	5763	10	days	day	NNS
cord-015021-pol2qm74	5763	11	,	,	,
cord-015021-pol2qm74	5763	12	both	both	CC
cord-015021-pol2qm74	5763	13	Ele	Ele	NNP
cord-015021-pol2qm74	5763	14	and	and	CC
cord-015021-pol2qm74	5763	15	SIRS	SIRS	NNP
cord-015021-pol2qm74	5763	16	showed	show	VBD
cord-015021-pol2qm74	5763	17	significant	significant	JJ
cord-015021-pol2qm74	5763	18	(	(	-LRB-
cord-015021-pol2qm74	5763	19	p<0.0001	p<0.0001	NNP
cord-015021-pol2qm74	5763	20	)	)	-RRB-
cord-015021-pol2qm74	5763	21	correlations	correlation	NNS
cord-015021-pol2qm74	5763	22	with	with	IN
cord-015021-pol2qm74	5763	23	parameters	parameter	NNS
cord-015021-pol2qm74	5763	24	reflecting	reflect	VBG
cord-015021-pol2qm74	5763	25	the	the	DT
cord-015021-pol2qm74	5763	26	general	general	JJ
cord-015021-pol2qm74	5763	27	and	and	CC
cord-015021-pol2qm74	5763	28	sepsis	sepsis	NN
cord-015021-pol2qm74	5763	29	-	-	HYPH
cord-015021-pol2qm74	5763	30	related	relate	VBN
cord-015021-pol2qm74	5763	31	severity	severity	NN
cord-015021-pol2qm74	5763	32	of	of	IN
cord-015021-pol2qm74	5763	33	the	the	DT
cord-015021-pol2qm74	5763	34	pop	pop	NN
cord-015021-pol2qm74	5763	35	.	.	.
cord-015021-pol2qm74	5764	1	clinical	clinical	JJ
cord-015021-pol2qm74	5764	2	course	course	NN
cord-015021-pol2qm74	5764	3	.	.	.
cord-015021-pol2qm74	5765	1	Compared	compare	VBN
cord-015021-pol2qm74	5765	2	to	to	IN
cord-015021-pol2qm74	5765	3	SIRS	SIRS	NNP
cord-015021-pol2qm74	5765	4	,	,	,
cord-015021-pol2qm74	5765	5	the	the	DT
cord-015021-pol2qm74	5765	6	Ele	Ele	NNP
cord-015021-pol2qm74	5765	7	correlations	correlation	NNS
cord-015021-pol2qm74	5765	8	were	be	VBD
cord-015021-pol2qm74	5765	9	better	well	JJR
cord-015021-pol2qm74	5765	10	(	(	-LRB-
cord-015021-pol2qm74	5765	11	ICU	ICU	NNP
cord-015021-pol2qm74	5765	12	mortality	mortality	NN
cord-015021-pol2qm74	5765	13	:	:	:
cord-015021-pol2qm74	5765	14	0.59	0.59	CD
cord-015021-pol2qm74	5765	15	vs.	vs.	IN
cord-015021-pol2qm74	5765	16	0.32	0.32	CD
cord-015021-pol2qm74	5765	17	;	;	:
cord-015021-pol2qm74	5765	18	ICU	ICU	NNP
cord-015021-pol2qm74	5765	19	treatment	treatment	NN
cord-015021-pol2qm74	5765	20	days	day	NNS
cord-015021-pol2qm74	5765	21	:	:	:
cord-015021-pol2qm74	5766	1	0,51	0,51	LS
cord-015021-pol2qm74	5766	2	vs.	vs.	NN
cord-015021-pol2qm74	5766	3	0.32	0.32	CD
cord-015021-pol2qm74	5766	4	;	;	:
cord-015021-pol2qm74	5766	5	days	day	NNS
cord-015021-pol2qm74	5766	6	on	on	IN
cord-015021-pol2qm74	5766	7	mechanical	mechanical	JJ
cord-015021-pol2qm74	5766	8	ventilation	ventilation	NN
cord-015021-pol2qm74	5766	9	:	:	:
cord-015021-pol2qm74	5766	10	0,54	0,54	NNP
cord-015021-pol2qm74	5766	11	vs.	vs.	FW
cord-015021-pol2qm74	5766	12	0.32	0.32	CD
cord-015021-pol2qm74	5766	13	;	;	:
cord-015021-pol2qm74	5766	14	days	day	NNS
cord-015021-pol2qm74	5766	15	with	with	IN
cord-015021-pol2qm74	5766	16	vasopressor	vasopressor	NN
cord-015021-pol2qm74	5766	17	requirement	requirement	NN
cord-015021-pol2qm74	5766	18	:	:	:
cord-015021-pol2qm74	5766	19	0.59	0.59	CD
cord-015021-pol2qm74	5766	20	vs.	vs.	IN
cord-015021-pol2qm74	5766	21	0.33	0.33	CD
cord-015021-pol2qm74	5766	22	;	;	:
cord-015021-pol2qm74	5766	23	number	number	NN
cord-015021-pol2qm74	5766	24	of	of	IN
cord-015021-pol2qm74	5766	25	microbiological	microbiological	JJ
cord-015021-pol2qm74	5766	26	findings	finding	NNS
cord-015021-pol2qm74	5766	27	:	:	:
cord-015021-pol2qm74	5766	28	0.44	0.44	CD
cord-015021-pol2qm74	5766	29	vs.	vs.	NN
cord-015021-pol2qm74	5766	30	0.29	0.29	CD
cord-015021-pol2qm74	5766	31	)	)	-RRB-
cord-015021-pol2qm74	5767	1	,	,	,
cord-015021-pol2qm74	5767	2	The	the	DT
cord-015021-pol2qm74	5767	3	optimal	optimal	JJ
cord-015021-pol2qm74	5767	4	classification	classification	NN
cord-015021-pol2qm74	5767	5	criteria	criterion	NNS
cord-015021-pol2qm74	5767	6	for	for	IN
cord-015021-pol2qm74	5767	7	the	the	DT
cord-015021-pol2qm74	5767	8	mainly	mainly	RB
cord-015021-pol2qm74	5767	9	sepsis	sepsis	NN
cord-015021-pol2qm74	5767	10	-	-	HYPH
cord-015021-pol2qm74	5767	11	related	relate	VBN
cord-015021-pol2qm74	5767	12	outcome	outcome	NN
cord-015021-pol2qm74	5767	13	gave	give	VBD
cord-015021-pol2qm74	5767	14	maximal	maximal	JJ
cord-015021-pol2qm74	5767	15	Youden	Youden	NNP
cord-015021-pol2qm74	5767	16	indices	index	NNS
cord-015021-pol2qm74	5767	17	of	of	IN
cord-015021-pol2qm74	5767	18	0.87	0.87	CD
cord-015021-pol2qm74	5767	19	for	for	IN
cord-015021-pol2qm74	5767	20	Ele	Ele	NNP
cord-015021-pol2qm74	5767	21	(	(	-LRB-
cord-015021-pol2qm74	5767	22	Ele	ele	NN
cord-015021-pol2qm74	5767	23	>	>	XX
cord-015021-pol2qm74	5768	1	_	_	NNP
cord-015021-pol2qm74	5768	2	12	12	CD
cord-015021-pol2qm74	5768	3	on	on	IN
cord-015021-pol2qm74	5769	1	>	>	XX
cord-015021-pol2qm74	5769	2	_	_	NN
cord-015021-pol2qm74	5769	3	2	2	CD
cord-015021-pol2qm74	5769	4	days	day	NNS
cord-015021-pol2qm74	5769	5	,	,	,
cord-015021-pol2qm74	5769	6	accuracy	accuracy	NN
cord-015021-pol2qm74	5769	7	:	:	:
cord-015021-pol2qm74	5769	8	94	94	CD
cord-015021-pol2qm74	5769	9	%	%	NN
cord-015021-pol2qm74	5769	10	)	)	-RRB-
cord-015021-pol2qm74	5769	11	compared	compare	VBN
cord-015021-pol2qm74	5769	12	to	to	IN
cord-015021-pol2qm74	5769	13	0.42	0.42	CD
cord-015021-pol2qm74	5769	14	for	for	IN
cord-015021-pol2qm74	5769	15	SIRS	SIRS	NNP
cord-015021-pol2qm74	5770	1	(	(	-LRB-
cord-015021-pol2qm74	5770	2	SIRS	sirs	UH
cord-015021-pol2qm74	5770	3	present	present	JJ
cord-015021-pol2qm74	5770	4	on	on	IN
cord-015021-pol2qm74	5770	5	>	>	$
cord-015021-pol2qm74	5770	6	3	3	CD
cord-015021-pol2qm74	5770	7	days	day	NNS
cord-015021-pol2qm74	5770	8	,	,	,
cord-015021-pol2qm74	5770	9	accuracy	accuracy	NN
cord-015021-pol2qm74	5770	10	:	:	:
cord-015021-pol2qm74	5770	11	67	67	CD
cord-015021-pol2qm74	5770	12	%	%	NN
cord-015021-pol2qm74	5770	13	)	)	-RRB-
cord-015021-pol2qm74	5770	14	.	.	.
cord-015021-pol2qm74	5771	1	Accordingly	accordingly	RB
cord-015021-pol2qm74	5771	2	,	,	,
cord-015021-pol2qm74	5771	3	Ele	Ele	NNP
cord-015021-pol2qm74	5771	4	ROC	ROC	NNP
cord-015021-pol2qm74	5771	5	curve	curve	NN
cord-015021-pol2qm74	5771	6	areas	area	NNS
cord-015021-pol2qm74	5771	7	for	for	IN
cord-015021-pol2qm74	5771	8	both	both	DT
cord-015021-pol2qm74	5771	9	overall	overall	JJ
cord-015021-pol2qm74	5771	10	(	(	-LRB-
cord-015021-pol2qm74	5771	11	0.92	0.92	CD
cord-015021-pol2qm74	5771	12	)	)	-RRB-
cord-015021-pol2qm74	5771	13	as	as	RB
cord-015021-pol2qm74	5771	14	well	well	RB
cord-015021-pol2qm74	5771	15	as	as	IN
cord-015021-pol2qm74	5771	16	sepsis	sepsis	NN
cord-015021-pol2qm74	5771	17	-	-	HYPH
cord-015021-pol2qm74	5771	18	related	relate	VBN
cord-015021-pol2qm74	5771	19	prognostic	prognostic	JJ
cord-015021-pol2qm74	5771	20	evaluation	evaluation	NN
cord-015021-pol2qm74	5771	21	(	(	-LRB-
cord-015021-pol2qm74	5771	22	0.99	0.99	CD
cord-015021-pol2qm74	5771	23	)	)	-RRB-
cord-015021-pol2qm74	5771	24	were	be	VBD
cord-015021-pol2qm74	5771	25	significantly	significantly	RB
cord-015021-pol2qm74	5771	26	(	(	-LRB-
cord-015021-pol2qm74	5771	27	p<0,05	p<0,05	NNP
cord-015021-pol2qm74	5771	28	)	)	-RRB-
cord-015021-pol2qm74	5771	29	larger	large	JJR
cord-015021-pol2qm74	5771	30	compared	compare	VBN
cord-015021-pol2qm74	5771	31	to	to	IN
cord-015021-pol2qm74	5771	32	SIRS	SIRS	NNP
cord-015021-pol2qm74	5771	33	(	(	-LRB-
cord-015021-pol2qm74	5771	34	0.79	0.79	CD
cord-015021-pol2qm74	5771	35	and	and	CC
cord-015021-pol2qm74	5771	36	0.86	0.86	CD
cord-015021-pol2qm74	5771	37	,	,	,
cord-015021-pol2qm74	5771	38	resp	resp	NNP
cord-015021-pol2qm74	5771	39	.	.	NNP
cord-015021-pol2qm74	5771	40	)	)	-RRB-
cord-015021-pol2qm74	5771	41	,	,	,
cord-015021-pol2qm74	5771	42	This	this	DT
cord-015021-pol2qm74	5771	43	higher	high	JJR
cord-015021-pol2qm74	5771	44	overall	overall	JJ
cord-015021-pol2qm74	5771	45	accuracy	accuracy	NN
cord-015021-pol2qm74	5771	46	of	of	IN
cord-015021-pol2qm74	5771	47	the	the	DT
cord-015021-pol2qm74	5771	48	Ele	Ele	NNP
cord-015021-pol2qm74	5771	49	criterion	criterion	NN
cord-015021-pol2qm74	5771	50	was	be	VBD
cord-015021-pol2qm74	5771	51	primary	primary	JJ
cord-015021-pol2qm74	5771	52	due	due	IN
cord-015021-pol2qm74	5771	53	to	to	IN
cord-015021-pol2qm74	5771	54	a	a	DT
cord-015021-pol2qm74	5771	55	more	more	RBR
cord-015021-pol2qm74	5771	56	valid	valid	JJ
cord-015021-pol2qm74	5771	57	assessment	assessment	NN
cord-015021-pol2qm74	5771	58	already	already	RB
cord-015021-pol2qm74	5771	59	on	on	IN
cord-015021-pol2qm74	5771	60	the	the	DT
cord-015021-pol2qm74	5771	61	first	first	JJ
cord-015021-pol2qm74	5771	62	and	and	CC
cord-015021-pol2qm74	5771	63	second	second	JJ
cord-015021-pol2qm74	5771	64	pop	pop	NN
cord-015021-pol2qm74	5771	65	.	.	.
cord-015021-pol2qm74	5772	1	day	day	NN
cord-015021-pol2qm74	5772	2	,	,	,
cord-015021-pol2qm74	5772	3	where	where	WRB
cord-015021-pol2qm74	5772	4	SIRS	SIRS	NNP
cord-015021-pol2qm74	5772	5	still	still	RB
cord-015021-pol2qm74	5772	6	had	have	VBD
cord-015021-pol2qm74	5772	7	a	a	DT
cord-015021-pol2qm74	5772	8	high	high	JJ
cord-015021-pol2qm74	5772	9	false	false	JJ
cord-015021-pol2qm74	5772	10	positive	positive	JJ
cord-015021-pol2qm74	5772	11	classification	classification	NN
cord-015021-pol2qm74	5772	12	rate	rate	NN
cord-015021-pol2qm74	5772	13	(	(	-LRB-
cord-015021-pol2qm74	5772	14	46	46	CD
cord-015021-pol2qm74	5772	15	%	%	NN
cord-015021-pol2qm74	5772	16	and	and	CC
cord-015021-pol2qm74	5772	17	53	53	CD
cord-015021-pol2qm74	5772	18	%	%	NN
cord-015021-pol2qm74	5772	19	,	,	,
cord-015021-pol2qm74	5772	20	compared	compare	VBN
cord-015021-pol2qm74	5772	21	to	to	IN
cord-015021-pol2qm74	5772	22	7	7	CD
cord-015021-pol2qm74	5772	23	%	%	NN
cord-015021-pol2qm74	5772	24	and	and	CC
cord-015021-pol2qm74	5772	25	1	1	CD
cord-015021-pol2qm74	5772	26	%	%	NN
cord-015021-pol2qm74	5772	27	,	,	,
cord-015021-pol2qm74	5772	28	resp	resp	NNP
cord-015021-pol2qm74	5772	29	.	.	.
cord-015021-pol2qm74	5772	30	)	)	-RRB-
cord-015021-pol2qm74	5772	31	.	.	.
cord-015021-pol2qm74	5773	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	5773	2	:	:	:
cord-015021-pol2qm74	5774	1	In	in	IN
cord-015021-pol2qm74	5774	2	the	the	DT
cord-015021-pol2qm74	5774	3	early	early	JJ
cord-015021-pol2qm74	5774	4	postoperative	postoperative	JJ
cord-015021-pol2qm74	5774	5	course	course	NN
cord-015021-pol2qm74	5774	6	after	after	IN
cord-015021-pol2qm74	5774	7	cardiac	cardiac	JJ
cord-015021-pol2qm74	5774	8	surgery	surgery	NN
cord-015021-pol2qm74	5774	9	,	,	,
cord-015021-pol2qm74	5774	10	the	the	DT
cord-015021-pol2qm74	5774	11	SIRS	SIRS	NNP
cord-015021-pol2qm74	5774	12	definition	definition	NN
cord-015021-pol2qm74	5774	13	displayed	display	VBD
cord-015021-pol2qm74	5774	14	a	a	DT
cord-015021-pol2qm74	5774	15	high	high	JJ
cord-015021-pol2qm74	5774	16	false	false	JJ
cord-015021-pol2qm74	5774	17	-	-	HYPH
cord-015021-pol2qm74	5774	18	positive	positive	JJ
cord-015021-pol2qm74	5774	19	classification	classification	NN
cord-015021-pol2qm74	5774	20	rate	rate	NN
cord-015021-pol2qm74	5774	21	(	(	-LRB-
cord-015021-pol2qm74	5774	22	low	low	JJ
cord-015021-pol2qm74	5774	23	specificity	specificity	NN
cord-015021-pol2qm74	5774	24	)	)	-RRB-
cord-015021-pol2qm74	5774	25	for	for	IN
cord-015021-pol2qm74	5774	26	subsequent	subsequent	JJ
cord-015021-pol2qm74	5774	27	sepsis	sepsis	NN
cord-015021-pol2qm74	5774	28	-	-	HYPH
cord-015021-pol2qm74	5774	29	related	relate	VBN
cord-015021-pol2qm74	5774	30	mortality	mortality	NN
cord-015021-pol2qm74	5774	31	compared	compare	VBN
cord-015021-pol2qm74	5774	32	to	to	IN
cord-015021-pol2qm74	5774	33	better	well	JJR
cord-015021-pol2qm74	5774	34	classification	classification	NN
cord-015021-pol2qm74	5774	35	results	result	NNS
cord-015021-pol2qm74	5774	36	obtained	obtain	VBN
cord-015021-pol2qm74	5774	37	by	by	IN
cord-015021-pol2qm74	5774	38	the	the	DT
cord-015021-pol2qm74	5774	39	Elebute	Elebute	NNP
cord-015021-pol2qm74	5774	40	sepsis	sepsis	NN
cord-015021-pol2qm74	5774	41	score	score	NN
cord-015021-pol2qm74	5774	42	.	.	.
cord-015021-pol2qm74	5775	1	From	from	IN
cord-015021-pol2qm74	5775	2	the	the	DT
cord-015021-pol2qm74	5775	3	Departments	Departments	NNPS
cord-015021-pol2qm74	5775	4	of	of	IN
cord-015021-pol2qm74	5775	5	Medicine	Medicine	NNP
cord-015021-pol2qm74	5775	6	I	I	NNP
cord-015021-pol2qm74	5775	7	and	and	CC
cord-015021-pol2qm74	5775	8	of	of	IN
cord-015021-pol2qm74	5775	9	"	"	``
cord-015021-pol2qm74	5775	10	Cardiac	Cardiac	NNP
cord-015021-pol2qm74	5775	11	Surgery	surgery	NN
cord-015021-pol2qm74	5775	12	,	,	,
cord-015021-pol2qm74	5775	13	Grosshadern	Grosshadern	NNP
cord-015021-pol2qm74	5775	14	University	University	NNP
cord-015021-pol2qm74	5775	15	Hospital	Hospital	NNP
cord-015021-pol2qm74	5775	16	,	,	,
cord-015021-pol2qm74	5775	17	Marchioninistr	Marchioninistr	NNP
cord-015021-pol2qm74	5775	18	.	.	.
cord-015021-pol2qm74	5776	1	15	15	CD
cord-015021-pol2qm74	5776	2	,	,	,
cord-015021-pol2qm74	5776	3	D-81377	D-81377	NNS
cord-015021-pol2qm74	5776	4	Munich	Munich	NNP
cord-015021-pol2qm74	5776	5	,	,	,
cord-015021-pol2qm74	5776	6	FRG	FRG	NNP
cord-015021-pol2qm74	5776	7	.	.	.
cord-015021-pol2qm74	5777	1	Correlation	correlation	NN
cord-015021-pol2qm74	5777	2	between	between	IN
cord-015021-pol2qm74	5777	3	physiological	physiological	JJ
cord-015021-pol2qm74	5777	4	and	and	CC
cord-015021-pol2qm74	5777	5	immunological	immunological	JJ
cord-015021-pol2qm74	5777	6	parameters	parameter	NNS
cord-015021-pol2qm74	5777	7	in	in	IN
cord-015021-pol2qm74	5777	8	critically	critically	RB
cord-015021-pol2qm74	5777	9	ill	ill	JJ
cord-015021-pol2qm74	5777	10	septic	septic	JJ
cord-015021-pol2qm74	5777	11	patients	patient	NNS
cord-015021-pol2qm74	5777	12	.	.	.
cord-015021-pol2qm74	5778	1	MA	MA	NNP
cord-015021-pol2qm74	5778	2	Rogy	Rogy	NNP
cord-015021-pol2qm74	5778	3	,	,	,
cord-015021-pol2qm74	5778	4	H	H	NNP
cord-015021-pol2qm74	5778	5	Oldenburg	Oldenburg	NNP
cord-015021-pol2qm74	5778	6	,	,	,
cord-015021-pol2qm74	5778	7	R	R	NNP
cord-015021-pol2qm74	5778	8	Trousdale	Trousdale	NNP
cord-015021-pol2qm74	5778	9	,	,	,
cord-015021-pol2qm74	5778	10	S	S	NNP
cord-015021-pol2qm74	5778	11	Coyle	Coyle	NNP
cord-015021-pol2qm74	5778	12	,	,	,
cord-015021-pol2qm74	5778	13	L	L	NNP
cord-015021-pol2qm74	5778	14	Moldawer	Moldawer	NNP
cord-015021-pol2qm74	5778	15	,	,	,
cord-015021-pol2qm74	5778	16	SF	SF	NNP
cord-015021-pol2qm74	5778	17	Lowry	Lowry	NNP
cord-015021-pol2qm74	5778	18	A	A	NNP
cord-015021-pol2qm74	5778	19	relationship	relationship	NN
cord-015021-pol2qm74	5778	20	between	between	IN
cord-015021-pol2qm74	5778	21	physiological	physiological	JJ
cord-015021-pol2qm74	5778	22	parameters	parameter	NNS
cord-015021-pol2qm74	5778	23	of	of	IN
cord-015021-pol2qm74	5778	24	severe	severe	JJ
cord-015021-pol2qm74	5778	25	sepsis	sepsis	NN
cord-015021-pol2qm74	5778	26	and	and	CC
cord-015021-pol2qm74	5778	27	immunological	immunological	JJ
cord-015021-pol2qm74	5778	28	function	function	NN
cord-015021-pol2qm74	5778	29	has	have	VBZ
cord-015021-pol2qm74	5778	30	not	not	RB
cord-015021-pol2qm74	5778	31	been	be	VBN
cord-015021-pol2qm74	5778	32	established	establish	VBN
cord-015021-pol2qm74	5778	33	.	.	.
cord-015021-pol2qm74	5779	1	In	in	IN
cord-015021-pol2qm74	5779	2	an	an	DT
cord-015021-pol2qm74	5779	3	effort	effort	NN
cord-015021-pol2qm74	5779	4	to	to	TO
cord-015021-pol2qm74	5779	5	assess	assess	VB
cord-015021-pol2qm74	5779	6	such	such	PDT
cord-015021-pol2qm74	5779	7	a	a	DT
cord-015021-pol2qm74	5779	8	relationship	relationship	NN
cord-015021-pol2qm74	5779	9	we	-PRON-	PRP
cord-015021-pol2qm74	5779	10	prospectively	prospectively	RB
cord-015021-pol2qm74	5779	11	evaluated	evaluate	VBD
cord-015021-pol2qm74	5779	12	nine	nine	CD
cord-015021-pol2qm74	5779	13	severely	severely	RB
cord-015021-pol2qm74	5779	14	ill	ill	JJ
cord-015021-pol2qm74	5779	15	septic	septic	JJ
cord-015021-pol2qm74	5779	16	patients	patient	NNS
cord-015021-pol2qm74	5779	17	.	.	.
cord-015021-pol2qm74	5780	1	Physiological	physiological	JJ
cord-015021-pol2qm74	5780	2	risk	risk	NN
cord-015021-pol2qm74	5780	3	was	be	VBD
cord-015021-pol2qm74	5780	4	assessed	assess	VBN
cord-015021-pol2qm74	5780	5	by	by	IN
cord-015021-pol2qm74	5780	6	the	the	DT
cord-015021-pol2qm74	5780	7	APACHE	APACHE	NNP
cord-015021-pol2qm74	5780	8	III	III	NNP
cord-015021-pol2qm74	5780	9	score	score	NN
cord-015021-pol2qm74	5780	10	1	1	CD
cord-015021-pol2qm74	5780	11	,	,	,
cord-015021-pol2qm74	5780	12	while	while	IN
cord-015021-pol2qm74	5780	13	one	one	CD
cord-015021-pol2qm74	5780	14	component	component	NN
cord-015021-pol2qm74	5780	15	of	of	IN
cord-015021-pol2qm74	5780	16	immunologic	immunologic	JJ
cord-015021-pol2qm74	5780	17	function	function	NN
cord-015021-pol2qm74	5780	18	was	be	VBD
cord-015021-pol2qm74	5780	19	evaluated	evaluate	VBN
cord-015021-pol2qm74	5780	20	by	by	IN
cord-015021-pol2qm74	5780	21	peripheral	peripheral	JJ
cord-015021-pol2qm74	5780	22	blood	blood	NN
cord-015021-pol2qm74	5780	23	mononuclear	mononuclear	NN
cord-015021-pol2qm74	5780	24	cells	cell	NNS
cord-015021-pol2qm74	5780	25	(	(	-LRB-
cord-015021-pol2qm74	5780	26	PBMC	PBMC	NNP
cord-015021-pol2qm74	5780	27	)	)	-RRB-
cord-015021-pol2qm74	5780	28	eytokine	eytokine	NN
cord-015021-pol2qm74	5780	29	production	production	NN
cord-015021-pol2qm74	5780	30	after	after	IN
cord-015021-pol2qm74	5780	31	in	in	IN
cord-015021-pol2qm74	5780	32	vitro	vitro	FW
cord-015021-pol2qm74	5780	33	LPS	LPS	NNP
cord-015021-pol2qm74	5780	34	stimulation	stimulation	NN
cord-015021-pol2qm74	5780	35	2	2	CD
cord-015021-pol2qm74	5780	36	.	.	.
cord-015021-pol2qm74	5781	1	Four	four	CD
cord-015021-pol2qm74	5781	2	of	of	IN
cord-015021-pol2qm74	5781	3	the	the	DT
cord-015021-pol2qm74	5781	4	nine	nine	CD
cord-015021-pol2qm74	5781	5	patients	patient	NNS
cord-015021-pol2qm74	5781	6	died	die	VBD
cord-015021-pol2qm74	5781	7	.	.	.
cord-015021-pol2qm74	5782	1	APACHE	APACHE	NNP
cord-015021-pol2qm74	5782	2	III	iii	CD
cord-015021-pol2qm74	5782	3	scores	score	NNS
cord-015021-pol2qm74	5782	4	at	at	IN
cord-015021-pol2qm74	5782	5	72	72	CD
cord-015021-pol2qm74	5782	6	h	h	NN
cord-015021-pol2qm74	5782	7	were	be	VBD
cord-015021-pol2qm74	5782	8	lower	low	JJR
cord-015021-pol2qm74	5782	9	in	in	IN
cord-015021-pol2qm74	5782	10	survivors	survivor	NNS
cord-015021-pol2qm74	5782	11	(	(	-LRB-
cord-015021-pol2qm74	5782	12	S	S	NNP
cord-015021-pol2qm74	5782	13	)	)	-RRB-
cord-015021-pol2qm74	5782	14	than	than	IN
cord-015021-pol2qm74	5782	15	in	in	IN
cord-015021-pol2qm74	5782	16	non	non	NNS
cord-015021-pol2qm74	5782	17	-	-	NNS
cord-015021-pol2qm74	5782	18	survivors	survivor	NNS
cord-015021-pol2qm74	5782	19	(	(	-LRB-
cord-015021-pol2qm74	5782	20	NS	NS	NNP
cord-015021-pol2qm74	5782	21	)	)	-RRB-
cord-015021-pol2qm74	5782	22	,	,	,
cord-015021-pol2qm74	5782	23	(	(	-LRB-
cord-015021-pol2qm74	5782	24	51-+13	51-+13	CD
cord-015021-pol2qm74	5782	25	vs	vs	IN
cord-015021-pol2qm74	5782	26	111-+1	111-+1	CD
cord-015021-pol2qm74	5782	27	5	5	CD
cord-015021-pol2qm74	5782	28	p<0.05	p<0.05	CD
cord-015021-pol2qm74	5782	29	)	)	-RRB-
cord-015021-pol2qm74	5782	30	,	,	,
cord-015021-pol2qm74	5782	31	while	while	IN
cord-015021-pol2qm74	5782	32	APACHE	APACHE	NNP
cord-015021-pol2qm74	5782	33	III	III	NNP
cord-015021-pol2qm74	5782	34	scores	score	NNS
cord-015021-pol2qm74	5782	35	at	at	IN
cord-015021-pol2qm74	5782	36	admission	admission	NN
cord-015021-pol2qm74	5782	37	were	be	VBD
cord-015021-pol2qm74	5782	38	not	not	RB
cord-015021-pol2qm74	5782	39	significant	significant	JJ
cord-015021-pol2qm74	5782	40	different	different	JJ
cord-015021-pol2qm74	5782	41	between	between	IN
cord-015021-pol2qm74	5782	42	S	S	NNP
cord-015021-pol2qm74	5782	43	and	and	CC
cord-015021-pol2qm74	5782	44	NS	NS	NNP
cord-015021-pol2qm74	5782	45	(	(	-LRB-
cord-015021-pol2qm74	5782	46	82-+13	82-+13	CD
cord-015021-pol2qm74	5782	47	vs	vs	IN
cord-015021-pol2qm74	5782	48	95-+13	95-+13	CD
cord-015021-pol2qm74	5782	49	)	)	-RRB-
cord-015021-pol2qm74	5782	50	.	.	.
cord-015021-pol2qm74	5783	1	Down	down	IN
cord-015021-pol2qm74	5783	2	regulation	regulation	NN
cord-015021-pol2qm74	5783	3	of	of	IN
cord-015021-pol2qm74	5783	4	cytokine	cytokine	NN
cord-015021-pol2qm74	5783	5	production	production	NN
cord-015021-pol2qm74	5783	6	by	by	IN
cord-015021-pol2qm74	5783	7	PBMC	PBMC	NNP
cord-015021-pol2qm74	5783	8	upon	upon	IN
cord-015021-pol2qm74	5783	9	LPS	LPS	NNP
cord-015021-pol2qm74	5783	10	stimulation	stimulation	NN
cord-015021-pol2qm74	5783	11	was	be	VBD
cord-015021-pol2qm74	5783	12	a	a	DT
cord-015021-pol2qm74	5783	13	transient	transient	JJ
cord-015021-pol2qm74	5783	14	event	event	NN
cord-015021-pol2qm74	5783	15	in	in	IN
cord-015021-pol2qm74	5783	16	S.	S.	NNP
cord-015021-pol2qm74	5783	17	While	while	IN
cord-015021-pol2qm74	5783	18	S	S	NNP
cord-015021-pol2qm74	5783	19	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	5783	20	an	an	DT
cord-015021-pol2qm74	5783	21	3	3	CD
cord-015021-pol2qm74	5783	22	fold	fold	JJ
cord-015021-pol2qm74	5783	23	increase	increase	NN
cord-015021-pol2qm74	5783	24	of	of	IN
cord-015021-pol2qm74	5783	25	TNF	TNF	NNP
cord-015021-pol2qm74	5783	26	-	-	:
cord-015021-pol2qm74	5783	27	a	a	DT
cord-015021-pol2qm74	5783	28	bioactivity	bioactivity	NN
cord-015021-pol2qm74	5784	1	with[r~	with[r~	NNP
cord-015021-pol2qm74	5785	1	72	72	CD
cord-015021-pol2qm74	5785	2	hours	hour	NNS
cord-015021-pol2qm74	5785	3	,	,	,
cord-015021-pol2qm74	5785	4	NS	NS	NNP
cord-015021-pol2qm74	5785	5	did	do	VBD
cord-015021-pol2qm74	5785	6	not	not	RB
cord-015021-pol2qm74	5785	7	demonstrate	demonstrate	VB
cord-015021-pol2qm74	5785	8	any	any	DT
cord-015021-pol2qm74	5785	9	increase	increase	NN
cord-015021-pol2qm74	5785	10	at	at	RB
cord-015021-pol2qm74	5785	11	all	all	RB
cord-015021-pol2qm74	5785	12	.	.	.
cord-015021-pol2qm74	5786	1	A	a	DT
cord-015021-pol2qm74	5786	2	similar	similar	JJ
cord-015021-pol2qm74	5786	3	pattern	pattern	NN
cord-015021-pol2qm74	5786	4	was	be	VBD
cord-015021-pol2qm74	5786	5	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	5786	6	for	for	IN
cord-015021-pol2qm74	5786	7	IL-1[3	il-1[3	JJ
cord-015021-pol2qm74	5786	8	and	and	CC
cord-015021-pol2qm74	5786	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	5786	10	immunoactivity	immunoactivity	NNP
cord-015021-pol2qm74	5786	11	.	.	.
cord-015021-pol2qm74	5787	1	TNF	TNF	NNP
cord-015021-pol2qm74	5787	2	was	be	VBD
cord-015021-pol2qm74	5787	3	measured	measure	VBN
cord-015021-pol2qm74	5787	4	by	by	IN
cord-015021-pol2qm74	5787	5	WEHI	WEHI	NNP
cord-015021-pol2qm74	5787	6	bioactivity	bioactivity	NN
cord-015021-pol2qm74	5787	7	,	,	,
cord-015021-pol2qm74	5787	8	IL-1[~	IL-1[~	NNP
cord-015021-pol2qm74	5787	9	and	and	CC
cord-015021-pol2qm74	5787	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	5787	11	immunoactivity	immunoactivity	NNP
cord-015021-pol2qm74	5787	12	were	be	VBD
cord-015021-pol2qm74	5787	13	determined	determine	VBN
cord-015021-pol2qm74	5787	14	by	by	IN
cord-015021-pol2qm74	5787	15	ELISA	ELISA	NNP
cord-015021-pol2qm74	5787	16	.	.	.
cord-015021-pol2qm74	5788	1	The	the	DT
cord-015021-pol2qm74	5788	2	sensitivity	sensitivity	NN
cord-015021-pol2qm74	5788	3	was	be	VBD
cord-015021-pol2qm74	5788	4	35	35	CD
cord-015021-pol2qm74	5788	5	pg	pg	NN
cord-015021-pol2qm74	5788	6	/	/	SYM
cord-015021-pol2qm74	5788	7	ml	ml	NN
cord-015021-pol2qm74	5788	8	for	for	IN
cord-015021-pol2qm74	5788	9	TNF	TNF	NNP
cord-015021-pol2qm74	5788	10	,	,	,
cord-015021-pol2qm74	5788	11	30	30	CD
cord-015021-pol2qm74	5788	12	pg	pg	NN
cord-015021-pol2qm74	5788	13	/	/	SYM
cord-015021-pol2qm74	5788	14	ml	ml	NN
cord-015021-pol2qm74	5788	15	for	for	IN
cord-015021-pol2qm74	5788	16	IL	IL	NNP
cord-015021-pol2qm74	5788	17	-	-	HYPH
cord-015021-pol2qm74	5788	18	ll3	ll3	NNS
cord-015021-pol2qm74	5788	19	and	and	CC
cord-015021-pol2qm74	5788	20	35	35	CD
cord-015021-pol2qm74	5788	21	pg	pg	NN
cord-015021-pol2qm74	5788	22	/	/	SYM
cord-015021-pol2qm74	5788	23	ml	ml	NN
cord-015021-pol2qm74	5788	24	for	for	IN
cord-015021-pol2qm74	5788	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	5788	26	,	,	,
cord-015021-pol2qm74	5788	27	respectively	respectively	RB
cord-015021-pol2qm74	5788	28	.	.	.
cord-015021-pol2qm74	5789	1	In	in	IN
cord-015021-pol2qm74	5789	2	conclusion	conclusion	NN
cord-015021-pol2qm74	5789	3	,	,	,
cord-015021-pol2qm74	5789	4	both	both	DT
cord-015021-pol2qm74	5789	5	physiological	physiological	JJ
cord-015021-pol2qm74	5789	6	as	as	RB
cord-015021-pol2qm74	5789	7	well	well	RB
cord-015021-pol2qm74	5789	8	as	as	IN
cord-015021-pol2qm74	5789	9	immunological	immunological	JJ
cord-015021-pol2qm74	5789	10	functions	function	NNS
cord-015021-pol2qm74	5789	11	of	of	IN
cord-015021-pol2qm74	5789	12	severe	severe	JJ
cord-015021-pol2qm74	5789	13	critically	critically	RB
cord-015021-pol2qm74	5789	14	ill	ill	JJ
cord-015021-pol2qm74	5789	15	septic	septic	JJ
cord-015021-pol2qm74	5789	16	patients	patient	NNS
cord-015021-pol2qm74	5789	17	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	5789	18	predictive	predictive	JJ
cord-015021-pol2qm74	5789	19	value	value	NN
cord-015021-pol2qm74	5789	20	for	for	IN
cord-015021-pol2qm74	5789	21	ultimate	ultimate	JJ
cord-015021-pol2qm74	5789	22	survival	survival	NN
cord-015021-pol2qm74	5789	23	.	.	.
cord-015021-pol2qm74	5790	1	While	while	IN
cord-015021-pol2qm74	5790	2	patients	patient	NNS
cord-015021-pol2qm74	5790	3	biological	biological	JJ
cord-015021-pol2qm74	5790	4	status	status	NN
cord-015021-pol2qm74	5790	5	seems	seem	VBZ
cord-015021-pol2qm74	5790	6	to	to	TO
cord-015021-pol2qm74	5790	7	be	be	VB
cord-015021-pol2qm74	5790	8	more	more	RBR
cord-015021-pol2qm74	5790	9	predictable	predictable	JJ
cord-015021-pol2qm74	5790	10	by	by	IN
cord-015021-pol2qm74	5790	11	APACHE	APACHE	NNP
cord-015021-pol2qm74	5790	12	III	III	NNP
cord-015021-pol2qm74	5790	13	at	at	IN
cord-015021-pol2qm74	5790	14	day	day	NN
cord-015021-pol2qm74	5790	15	3	3	CD
cord-015021-pol2qm74	5790	16	,	,	,
cord-015021-pol2qm74	5790	17	p<0.05	p<0.05	CD
cord-015021-pol2qm74	5790	18	,	,	,
cord-015021-pol2qm74	5790	19	the	the	DT
cord-015021-pol2qm74	5790	20	pattern	pattern	NN
cord-015021-pol2qm74	5790	21	of	of	IN
cord-015021-pol2qm74	5790	22	cytokine	cytokine	NN
cord-015021-pol2qm74	5790	23	production	production	NN
cord-015021-pol2qm74	5790	24	by	by	IN
cord-015021-pol2qm74	5790	25	PBMC	PBMC	NNP
cord-015021-pol2qm74	5790	26	upon	upon	IN
cord-015021-pol2qm74	5790	27	LPS	LPS	NNP
cord-015021-pol2qm74	5790	28	stimulation	stimulation	NN
cord-015021-pol2qm74	5790	29	over	over	IN
cord-015021-pol2qm74	5790	30	the	the	DT
cord-015021-pol2qm74	5790	31	first	first	JJ
cord-015021-pol2qm74	5790	32	72h	72h	NNS
cord-015021-pol2qm74	5790	33	might	may	MD
cord-015021-pol2qm74	5790	34	be	be	VB
cord-015021-pol2qm74	5790	35	a	a	DT
cord-015021-pol2qm74	5790	36	reliable	reliable	JJ
cord-015021-pol2qm74	5790	37	predictor	predictor	NN
cord-015021-pol2qm74	5790	38	as	as	RB
cord-015021-pol2qm74	5790	39	well	well	RB
cord-015021-pol2qm74	5790	40	.	.	.
cord-015021-pol2qm74	5791	1	Introduction	introduction	NN
cord-015021-pol2qm74	5791	2	:	:	:
cord-015021-pol2qm74	5791	3	Therapy	therapy	NN
cord-015021-pol2qm74	5791	4	of	of	IN
cord-015021-pol2qm74	5791	5	sepsis	sepsis	NN
cord-015021-pol2qm74	5791	6	and	and	CC
cord-015021-pol2qm74	5791	7	its	-PRON-	PRP$
cord-015021-pol2qm74	5791	8	sequelae	sequela	NNS
cord-015021-pol2qm74	5791	9	depends	depend	VBZ
cord-015021-pol2qm74	5791	10	largely	largely	RB
cord-015021-pol2qm74	5791	11	on	on	IN
cord-015021-pol2qm74	5791	12	its	-PRON-	PRP$
cord-015021-pol2qm74	5791	13	early	early	JJ
cord-015021-pol2qm74	5791	14	recognition	recognition	NN
cord-015021-pol2qm74	5791	15	.	.	.
cord-015021-pol2qm74	5792	1	Many	many	JJ
cord-015021-pol2qm74	5792	2	studies	study	NNS
cord-015021-pol2qm74	5792	3	have	have	VBP
cord-015021-pol2qm74	5792	4	investigated	investigate	VBN
cord-015021-pol2qm74	5792	5	the	the	DT
cord-015021-pol2qm74	5792	6	change	change	NN
cord-015021-pol2qm74	5792	7	of	of	IN
cord-015021-pol2qm74	5792	8	certain	certain	JJ
cord-015021-pol2qm74	5792	9	mediators	mediator	NNS
cord-015021-pol2qm74	5792	10	during	during	IN
cord-015021-pol2qm74	5792	11	sepsis	sepsis	NN
cord-015021-pol2qm74	5792	12	and	and	CC
cord-015021-pol2qm74	5792	13	their	-PRON-	PRP$
cord-015021-pol2qm74	5792	14	potential	potential	NN
cord-015021-pol2qm74	5792	15	to	to	TO
cord-015021-pol2qm74	5792	16	predict	predict	VB
cord-015021-pol2qm74	5792	17	multiple	multiple	JJ
cord-015021-pol2qm74	5792	18	organ	organ	NN
cord-015021-pol2qm74	5792	19	failure	failure	NN
cord-015021-pol2qm74	5792	20	and	and	CC
cord-015021-pol2qm74	5792	21	outcome	outcome	NN
cord-015021-pol2qm74	5792	22	.	.	.
cord-015021-pol2qm74	5793	1	It	-PRON-	PRP
cord-015021-pol2qm74	5793	2	was	be	VBD
cord-015021-pol2qm74	5793	3	the	the	DT
cord-015021-pol2qm74	5793	4	objective	objective	NN
cord-015021-pol2qm74	5793	5	of	of	IN
cord-015021-pol2qm74	5793	6	this	this	DT
cord-015021-pol2qm74	5793	7	study	study	NN
cord-015021-pol2qm74	5793	8	to	to	TO
cord-015021-pol2qm74	5793	9	investigate	investigate	VB
cord-015021-pol2qm74	5793	10	whether	whether	IN
cord-015021-pol2qm74	5793	11	the	the	DT
cord-015021-pol2qm74	5793	12	onset	onset	NN
cord-015021-pol2qm74	5793	13	of	of	IN
cord-015021-pol2qm74	5793	14	sepsis	sepsis	NN
cord-015021-pol2qm74	5793	15	can	can	MD
cord-015021-pol2qm74	5793	16	be	be	VB
cord-015021-pol2qm74	5793	17	predicted	predict	VBN
cord-015021-pol2qm74	5793	18	by	by	IN
cord-015021-pol2qm74	5793	19	alterations	alteration	NNS
cord-015021-pol2qm74	5793	20	of	of	IN
cord-015021-pol2qm74	5793	21	levels	level	NNS
cord-015021-pol2qm74	5793	22	of	of	IN
cord-015021-pol2qm74	5793	23	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	5793	24	(	(	-LRB-
cord-015021-pol2qm74	5793	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	5793	26	)	)	-RRB-
cord-015021-pol2qm74	5793	27	,	,	,
cord-015021-pol2qm74	5793	28	tumour	tumour	NN
cord-015021-pol2qm74	5793	29	-	-	HYPH
cord-015021-pol2qm74	5793	30	necrosis	necrosis	NN
cord-015021-pol2qm74	5793	31	-	-	HYPH
cord-015021-pol2qm74	5793	32	factor	factor	NN
cord-015021-pol2qm74	5793	33	(	(	-LRB-
cord-015021-pol2qm74	5793	34	TNF	TNF	NNP
cord-015021-pol2qm74	5793	35	)	)	-RRB-
cord-015021-pol2qm74	5793	36	,	,	,
cord-015021-pol2qm74	5793	37	PMN	pmn	NN
cord-015021-pol2qm74	5793	38	-	-	HYPH
cord-015021-pol2qm74	5793	39	elastase	elastase	NN
cord-015021-pol2qm74	5793	40	and	and	CC
cord-015021-pol2qm74	5793	41	C	c	NN
cord-015021-pol2qm74	5793	42	-	-	HYPH
cord-015021-pol2qm74	5793	43	reactive	reactive	JJ
cord-015021-pol2qm74	5793	44	protein	protein	NN
cord-015021-pol2qm74	5793	45	(	(	-LRB-
cord-015021-pol2qm74	5793	46	CRP	CRP	NNP
cord-015021-pol2qm74	5793	47	)	)	-RRB-
cord-015021-pol2qm74	5793	48	.	.	.
cord-015021-pol2qm74	5794	1	Materials	material	NNS
cord-015021-pol2qm74	5794	2	and	and	CC
cord-015021-pol2qm74	5794	3	methods	method	NNS
cord-015021-pol2qm74	5794	4	:	:	:
cord-015021-pol2qm74	5794	5	Over	over	IN
cord-015021-pol2qm74	5794	6	a	a	DT
cord-015021-pol2qm74	5794	7	one	one	CD
cord-015021-pol2qm74	5794	8	year	year	NN
cord-015021-pol2qm74	5794	9	period	period	NN
cord-015021-pol2qm74	5794	10	,	,	,
cord-015021-pol2qm74	5794	11	40	40	CD
cord-015021-pol2qm74	5794	12	polytraumatized	polytraumatize	VBN
cord-015021-pol2qm74	5794	13	patients	patient	NNS
cord-015021-pol2qm74	5794	14	were	be	VBD
cord-015021-pol2qm74	5794	15	prospectively	prospectively	RB
cord-015021-pol2qm74	5794	16	studied	study	VBN
cord-015021-pol2qm74	5794	17	(	(	-LRB-
cord-015021-pol2qm74	5794	18	mean	mean	VBP
cord-015021-pol2qm74	5794	19	age	age	NN
cord-015021-pol2qm74	5794	20	42y	42y	CD
cord-015021-pol2qm74	5794	21	,	,	,
cord-015021-pol2qm74	5794	22	71	71	CD
cord-015021-pol2qm74	5794	23	%	%	NN
cord-015021-pol2qm74	5794	24	male	male	NN
cord-015021-pol2qm74	5794	25	,	,	,
cord-015021-pol2qm74	5794	26	ISS	ISS	NNP
cord-015021-pol2qm74	5794	27	28	28	CD
cord-015021-pol2qm74	5794	28	)	)	-RRB-
cord-015021-pol2qm74	5794	29	.	.	.
cord-015021-pol2qm74	5795	1	Serum	serum	NN
cord-015021-pol2qm74	5795	2	and	and	CC
cord-015021-pol2qm74	5795	3	EDTA	edta	NN
cord-015021-pol2qm74	5795	4	-	-	HYPH
cord-015021-pol2qm74	5795	5	plasma	plasma	NN
cord-015021-pol2qm74	5795	6	samples	sample	NNS
cord-015021-pol2qm74	5795	7	were	be	VBD
cord-015021-pol2qm74	5795	8	taken	take	VBN
cord-015021-pol2qm74	5795	9	in	in	RP
cord-015021-pol2qm74	5795	10	12h	12h	CD
cord-015021-pol2qm74	5795	11	intervalls	intervall	NNS
cord-015021-pol2qm74	5795	12	until	until	IN
cord-015021-pol2qm74	5795	13	the	the	DT
cord-015021-pol2qm74	5795	14	patient	patient	NN
cord-015021-pol2qm74	5795	15	left	leave	VBD
cord-015021-pol2qm74	5795	16	the	the	DT
cord-015021-pol2qm74	5795	17	ICU	ICU	NNP
cord-015021-pol2qm74	5795	18	.	.	.
cord-015021-pol2qm74	5796	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	5796	2	,	,	,
cord-015021-pol2qm74	5796	3	TNF	TNF	NNP
cord-015021-pol2qm74	5796	4	,	,	,
cord-015021-pol2qm74	5796	5	elastase	elastase	NN
cord-015021-pol2qm74	5796	6	,	,	,
cord-015021-pol2qm74	5796	7	and	and	CC
cord-015021-pol2qm74	5796	8	CRP	CRP	NNP
cord-015021-pol2qm74	5796	9	were	be	VBD
cord-015021-pol2qm74	5796	10	determined	determine	VBN
cord-015021-pol2qm74	5796	11	immunologically	immunologically	RB
cord-015021-pol2qm74	5796	12	.	.	.
cord-015021-pol2qm74	5797	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	5797	2	was	be	VBD
cord-015021-pol2qm74	5797	3	defined	define	VBN
cord-015021-pol2qm74	5797	4	according	accord	VBG
cord-015021-pol2qm74	5797	5	to	to	IN
cord-015021-pol2qm74	5797	6	the	the	DT
cord-015021-pol2qm74	5797	7	criteria	criterion	NNS
cord-015021-pol2qm74	5797	8	of	of	IN
cord-015021-pol2qm74	5797	9	'	'	``
cord-015021-pol2qm74	5797	10	systemic	systemic	JJ
cord-015021-pol2qm74	5797	11	sepsis	sepsis	NN
cord-015021-pol2qm74	5797	12	'	'	''
cord-015021-pol2qm74	5797	13	(	(	-LRB-
cord-015021-pol2qm74	5797	14	Veterans	Veterans	NNPS
cord-015021-pol2qm74	5797	15	"	"	''
cord-015021-pol2qm74	5797	16	Administration	Administration	NNP
cord-015021-pol2qm74	5797	17	Study	Study	NNP
cord-015021-pol2qm74	5797	18	,	,	,
cord-015021-pol2qm74	5797	19	1987	1987	CD
cord-015021-pol2qm74	5797	20	)	)	-RRB-
cord-015021-pol2qm74	5797	21	with	with	IN
cord-015021-pol2qm74	5797	22	at	at	RB
cord-015021-pol2qm74	5797	23	least	least	JJS
cord-015021-pol2qm74	5797	24	4	4	CD
cord-015021-pol2qm74	5797	25	of	of	IN
cord-015021-pol2qm74	5797	26	7	7	CD
cord-015021-pol2qm74	5797	27	clinical	clinical	JJ
cord-015021-pol2qm74	5797	28	signs	sign	NNS
cord-015021-pol2qm74	5797	29	:	:	:
cord-015021-pol2qm74	5797	30	(	(	-LRB-
cord-015021-pol2qm74	5797	31	1	1	LS
cord-015021-pol2qm74	5797	32	)	)	-RRB-
cord-015021-pol2qm74	5797	33	tachycar	tachycar	JJ
cord-015021-pol2qm74	5797	34	-	-	HYPH
cord-015021-pol2qm74	5797	35	dia	dia	NNP
cord-015021-pol2qm74	5797	36	>	>	XX
cord-015021-pol2qm74	5797	37	100	100	CD
cord-015021-pol2qm74	5797	38	/	/	SYM
cord-015021-pol2qm74	5797	39	min	min	NN
cord-015021-pol2qm74	5797	40	,	,	,
cord-015021-pol2qm74	5797	41	(	(	-LRB-
cord-015021-pol2qm74	5797	42	2	2	LS
cord-015021-pol2qm74	5797	43	)	)	-RRB-
cord-015021-pol2qm74	5797	44	temperature	temperature	NN
cord-015021-pol2qm74	5797	45	>	>	XX
cord-015021-pol2qm74	5798	1	38,9	38,9	CD
cord-015021-pol2qm74	5798	2	°	°	NNP
cord-015021-pol2qm74	5798	3	C	C	NNP
cord-015021-pol2qm74	5798	4	,	,	,
cord-015021-pol2qm74	5798	5	(	(	-LRB-
cord-015021-pol2qm74	5798	6	3	3	LS
cord-015021-pol2qm74	5798	7	)	)	-RRB-
cord-015021-pol2qm74	5798	8	blood	blood	NN
cord-015021-pol2qm74	5798	9	pressure	pressure	NN
cord-015021-pol2qm74	5798	10	<	<	XX
cord-015021-pol2qm74	5798	11	100mmHg	100mmhg	CD
cord-015021-pol2qm74	5798	12	,	,	,
cord-015021-pol2qm74	5798	13	(	(	-LRB-
cord-015021-pol2qm74	5798	14	4	4	LS
cord-015021-pol2qm74	5798	15	)	)	-RRB-
cord-015021-pol2qm74	5798	16	mechanical	mechanical	JJ
cord-015021-pol2qm74	5798	17	ventilation	ventilation	NN
cord-015021-pol2qm74	5798	18	,	,	,
cord-015021-pol2qm74	5799	1	(	(	-LRB-
cord-015021-pol2qm74	5799	2	5	5	LS
cord-015021-pol2qm74	5799	3	)	)	-RRB-
cord-015021-pol2qm74	5799	4	leukocytosis	leukocytosis	NN
cord-015021-pol2qm74	5799	5	>	>	XX
cord-015021-pol2qm74	5800	1	15.000	15.000	CD
cord-015021-pol2qm74	5800	2	/ml	/ml	NFP
cord-015021-pol2qm74	5800	3	,	,	,
cord-015021-pol2qm74	5800	4	(	(	-LRB-
cord-015021-pol2qm74	5800	5	6	6	LS
cord-015021-pol2qm74	5800	6	)	)	-RRB-
cord-015021-pol2qm74	5800	7	thrombocytopenia	thrombocytopenia	NN
cord-015021-pol2qm74	5801	1	<	<	XX
cord-015021-pol2qm74	5802	1	100.000	100.000	CD
cord-015021-pol2qm74	5802	2	/	/	SYM
cord-015021-pol2qm74	5802	3	ml	ml	NN
cord-015021-pol2qm74	5802	4	and	and	CC
cord-015021-pol2qm74	5802	5	(	(	-LRB-
cord-015021-pol2qm74	5802	6	7	7	LS
cord-015021-pol2qm74	5802	7	)	)	-RRB-
cord-015021-pol2qm74	5802	8	presence	presence	NN
cord-015021-pol2qm74	5802	9	of	of	IN
cord-015021-pol2qm74	5802	10	an	an	DT
cord-015021-pol2qm74	5802	11	obvious	obvious	JJ
cord-015021-pol2qm74	5802	12	septic	septic	JJ
cord-015021-pol2qm74	5802	13	focus	focus	NN
cord-015021-pol2qm74	5802	14	.	.	.
cord-015021-pol2qm74	5803	1	Clinical	clinical	JJ
cord-015021-pol2qm74	5803	2	parameters	parameter	NNS
cord-015021-pol2qm74	5803	3	,	,	,
cord-015021-pol2qm74	5803	4	sepsis	sepsis	NN
cord-015021-pol2qm74	5803	5	severity	severity	NN
cord-015021-pol2qm74	5803	6	and	and	CC
cord-015021-pol2qm74	5803	7	serum	serum	NN
cord-015021-pol2qm74	5803	8	levels	level	NNS
cord-015021-pol2qm74	5803	9	were	be	VBD
cord-015021-pol2qm74	5803	10	documented	document	VBN
cord-015021-pol2qm74	5803	11	on	on	IN
cord-015021-pol2qm74	5803	12	a	a	DT
cord-015021-pol2qm74	5803	13	daily	daily	JJ
cord-015021-pol2qm74	5803	14	basis	basis	NN
cord-015021-pol2qm74	5803	15	,	,	,
cord-015021-pol2qm74	5803	16	beginning	begin	VBG
cord-015021-pol2qm74	5803	17	on	on	IN
cord-015021-pol2qm74	5803	18	day	day	NN
cord-015021-pol2qm74	5803	19	2	2	CD
cord-015021-pol2qm74	5803	20	after	after	IN
cord-015021-pol2qm74	5803	21	trauma	trauma	NN
cord-015021-pol2qm74	5803	22	.	.	.
cord-015021-pol2qm74	5804	1	Results	result	NNS
cord-015021-pol2qm74	5804	2	:	:	:
cord-015021-pol2qm74	5804	3	21	21	CD
cord-015021-pol2qm74	5804	4	of	of	IN
cord-015021-pol2qm74	5804	5	40	40	CD
cord-015021-pol2qm74	5804	6	patients	patient	NNS
cord-015021-pol2qm74	5804	7	developed	develop	VBD
cord-015021-pol2qm74	5804	8	a	a	DT
cord-015021-pol2qm74	5804	9	systemic	systemic	JJ
cord-015021-pol2qm74	5804	10	sepsis	sepsis	NN
cord-015021-pol2qm74	5804	11	(	(	-LRB-
cord-015021-pol2qm74	5804	12	52.5	52.5	CD
cord-015021-pol2qm74	5804	13	%	%	NN
cord-015021-pol2qm74	5804	14	)	)	-RRB-
cord-015021-pol2qm74	5804	15	,	,	,
cord-015021-pol2qm74	5804	16	and	and	CC
cord-015021-pol2qm74	5804	17	5	5	CD
cord-015021-pol2qm74	5804	18	died	die	VBD
cord-015021-pol2qm74	5804	19	.	.	.
cord-015021-pol2qm74	5805	1	All	all	DT
cord-015021-pol2qm74	5805	2	mediator	mediator	NN
cord-015021-pol2qm74	5805	3	levels	level	NNS
cord-015021-pol2qm74	5805	4	were	be	VBD
cord-015021-pol2qm74	5805	5	elevated	elevate	VBN
cord-015021-pol2qm74	5805	6	under	under	IN
cord-015021-pol2qm74	5805	7	septic	septic	JJ
cord-015021-pol2qm74	5805	8	conditions	condition	NNS
cord-015021-pol2qm74	5805	9	.	.	.
cord-015021-pol2qm74	5806	1	The	the	DT
cord-015021-pol2qm74	5806	2	clinical	clinical	JJ
cord-015021-pol2qm74	5806	3	severity	severity	NN
cord-015021-pol2qm74	5806	4	of	of	IN
cord-015021-pol2qm74	5806	5	sepsis	sepsis	NN
cord-015021-pol2qm74	5806	6	correlated	correlate	VBN
cord-015021-pol2qm74	5806	7	well	well	RB
cord-015021-pol2qm74	5806	8	with	with	IN
cord-015021-pol2qm74	5806	9	the	the	DT
cord-015021-pol2qm74	5806	10	respective	respective	JJ
cord-015021-pol2qm74	5806	11	levels	level	NNS
cord-015021-pol2qm74	5806	12	of	of	IN
cord-015021-pol2qm74	5806	13	mediators	mediator	NNS
cord-015021-pol2qm74	5806	14	.	.	.
cord-015021-pol2qm74	5807	1	In	in	IN
cord-015021-pol2qm74	5807	2	patients	patient	NNS
cord-015021-pol2qm74	5807	3	,	,	,
cord-015021-pol2qm74	5807	4	who	who	WP
cord-015021-pol2qm74	5807	5	developed	develop	VBD
cord-015021-pol2qm74	5807	6	a	a	DT
cord-015021-pol2qm74	5807	7	sepsis	sepsis	NN
cord-015021-pol2qm74	5807	8	the	the	DT
cord-015021-pol2qm74	5807	9	following	follow	VBG
cord-015021-pol2qm74	5807	10	day	day	NN
cord-015021-pol2qm74	5807	11	,	,	,
cord-015021-pol2qm74	5807	12	IL-6	IL-6	NNP
cord-015021-pol2qm74	5807	13	(	(	-LRB-
cord-015021-pol2qm74	5807	14	510	510	CD
cord-015021-pol2qm74	5807	15	vs.	vs.	IN
cord-015021-pol2qm74	5807	16	195	195	CD
cord-015021-pol2qm74	5807	17	ng	ng	NN
cord-015021-pol2qm74	5807	18	/	/	SYM
cord-015021-pol2qm74	5807	19	l	l	NN
cord-015021-pol2qm74	5807	20	;	;	:
cord-015021-pol2qm74	5807	21	p=0.029	p=0.029	NNP
cord-015021-pol2qm74	5807	22	)	)	-RRB-
cord-015021-pol2qm74	5807	23	,	,	,
cord-015021-pol2qm74	5807	24	CRP	CRP	NNP
cord-015021-pol2qm74	5807	25	(	(	-LRB-
cord-015021-pol2qm74	5807	26	160	160	CD
cord-015021-pol2qm74	5807	27	vs.	vs.	NN
cord-015021-pol2qm74	5807	28	121	121	CD
cord-015021-pol2qm74	5807	29	mg	mg	NNP
cord-015021-pol2qm74	5807	30	/	/	SYM
cord-015021-pol2qm74	5807	31	l	l	NN
cord-015021-pol2qm74	5807	32	;	;	:
cord-015021-pol2qm74	5807	33	p=0.035	p=0.035	NNP
cord-015021-pol2qm74	5807	34	)	)	-RRB-
cord-015021-pol2qm74	5807	35	and	and	CC
cord-015021-pol2qm74	5807	36	TNF	TNF	NNP
cord-015021-pol2qm74	5807	37	(	(	-LRB-
cord-015021-pol2qm74	5807	38	32	32	CD
cord-015021-pol2qm74	5807	39	vs.	vs.	NN
cord-015021-pol2qm74	5807	40	15	15	CD
cord-015021-pol2qm74	5807	41	ng	ng	NNP
cord-015021-pol2qm74	5807	42	/	/	SYM
cord-015021-pol2qm74	5807	43	l	l	NN
cord-015021-pol2qm74	5807	44	;	;	:
cord-015021-pol2qm74	5807	45	p=0.045	p=0.045	NNP
cord-015021-pol2qm74	5807	46	)	)	-RRB-
cord-015021-pol2qm74	5807	47	were	be	VBD
cord-015021-pol2qm74	5807	48	significantly	significantly	RB
cord-015021-pol2qm74	5807	49	increased	increase	VBN
cord-015021-pol2qm74	5807	50	as	as	IN
cord-015021-pol2qm74	5807	51	compared	compare	VBN
cord-015021-pol2qm74	5807	52	to	to	IN
cord-015021-pol2qm74	5807	53	those	those	DT
cord-015021-pol2qm74	5807	54	patients	patient	NNS
cord-015021-pol2qm74	5807	55	who	who	WP
cord-015021-pol2qm74	5807	56	remained	remain	VBD
cord-015021-pol2qm74	5807	57	non	non	JJ
cord-015021-pol2qm74	5807	58	-	-	JJ
cord-015021-pol2qm74	5807	59	septic	septic	JJ
cord-015021-pol2qm74	5807	60	.	.	.
cord-015021-pol2qm74	5808	1	Elastase	Elastase	NNP
cord-015021-pol2qm74	5808	2	levels	level	NNS
cord-015021-pol2qm74	5808	3	were	be	VBD
cord-015021-pol2qm74	5808	4	considerably	considerably	RB
cord-015021-pol2qm74	5808	5	elevated	elevated	JJ
cord-015021-pol2qm74	5808	6	but	but	CC
cord-015021-pol2qm74	5808	7	did	do	VBD
cord-015021-pol2qm74	5808	8	not	not	RB
cord-015021-pol2qm74	5808	9	reach	reach	VB
cord-015021-pol2qm74	5808	10	the	the	DT
cord-015021-pol2qm74	5808	11	level	level	NN
cord-015021-pol2qm74	5808	12	of	of	IN
cord-015021-pol2qm74	5808	13	significance	significance	NN
cord-015021-pol2qm74	5808	14	.	.	.
cord-015021-pol2qm74	5809	1	We	-PRON-	PRP
cord-015021-pol2qm74	5809	2	conclude	conclude	VBP
cord-015021-pol2qm74	5809	3	that	that	IN
cord-015021-pol2qm74	5809	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	5809	5	,	,	,
cord-015021-pol2qm74	5809	6	TNF	TNF	NNP
cord-015021-pol2qm74	5809	7	and	and	CC
cord-015021-pol2qm74	5809	8	CRP	CRP	NNP
cord-015021-pol2qm74	5809	9	appear	appear	VBP
cord-015021-pol2qm74	5809	10	to	to	TO
cord-015021-pol2qm74	5809	11	be	be	VB
cord-015021-pol2qm74	5809	12	sensitive	sensitive	JJ
cord-015021-pol2qm74	5809	13	markers	marker	NNS
cord-015021-pol2qm74	5809	14	for	for	IN
cord-015021-pol2qm74	5809	15	prediction	prediction	NN
cord-015021-pol2qm74	5809	16	of	of	IN
cord-015021-pol2qm74	5809	17	septic	septic	JJ
cord-015021-pol2qm74	5809	18	complications	complication	NNS
cord-015021-pol2qm74	5809	19	in	in	IN
cord-015021-pol2qm74	5809	20	polytraumatized	polytraumatize	VBN
cord-015021-pol2qm74	5809	21	patients	patient	NNS
cord-015021-pol2qm74	5809	22	.	.	.
cord-015021-pol2qm74	5810	1	Objectives	objective	NNS
cord-015021-pol2qm74	5810	2	of	of	IN
cord-015021-pol2qm74	5810	3	the	the	DT
cord-015021-pol2qm74	5810	4	study	study	NN
cord-015021-pol2qm74	5810	5	:	:	:
cord-015021-pol2qm74	5810	6	The	the	DT
cord-015021-pol2qm74	5810	7	assessment	assessment	NN
cord-015021-pol2qm74	5810	8	of	of	IN
cord-015021-pol2qm74	5810	9	liver	liver	NN
cord-015021-pol2qm74	5810	10	function	function	NN
cord-015021-pol2qm74	5810	11	in	in	IN
cord-015021-pol2qm74	5810	12	polytraumatized	polytraumatize	VBN
cord-015021-pol2qm74	5810	13	patients	patient	NNS
cord-015021-pol2qm74	5810	14	who	who	WP
cord-015021-pol2qm74	5810	15	are	be	VBP
cord-015021-pol2qm74	5810	16	at	at	IN
cord-015021-pol2qm74	5810	17	risk	risk	NN
cord-015021-pol2qm74	5810	18	of	of	IN
cord-015021-pol2qm74	5810	19	developing	develop	VBG
cord-015021-pol2qm74	5810	20	MOF	MOF	NNP
cord-015021-pol2qm74	5810	21	is	be	VBZ
cord-015021-pol2qm74	5810	22	too	too	RB
cord-015021-pol2qm74	5810	23	inaccurate	inaccurate	JJ
cord-015021-pol2qm74	5810	24	and	and	CC
cord-015021-pol2qm74	5810	25	late	late	RB
cord-015021-pol2qm74	5810	26	by	by	IN
cord-015021-pol2qm74	5810	27	using	use	VBG
cord-015021-pol2qm74	5810	28	conventional	conventional	JJ
cord-015021-pol2qm74	5810	29	biochemical	biochemical	JJ
cord-015021-pol2qm74	5810	30	parameters	parameter	NNS
cord-015021-pol2qm74	5810	31	.	.	.
cord-015021-pol2qm74	5811	1	Methats	Methats	NNP
cord-015021-pol2qm74	5811	2	:	:	:
cord-015021-pol2qm74	5812	1	The	the	DT
cord-015021-pol2qm74	5812	2	injury	injury	NN
cord-015021-pol2qm74	5812	3	severity	severity	NN
cord-015021-pol2qm74	5812	4	of	of	IN
cord-015021-pol2qm74	5812	5	the	the	DT
cord-015021-pol2qm74	5812	6	patients	patient	NNS
cord-015021-pol2qm74	5812	7	(	(	-LRB-
cord-015021-pol2qm74	5812	8	n=26	n=26	RB
cord-015021-pol2qm74	5812	9	)	)	-RRB-
cord-015021-pol2qm74	5812	10	was	be	VBD
cord-015021-pol2qm74	5812	11	determined	determine	VBN
cord-015021-pol2qm74	5812	12	by	by	IN
cord-015021-pol2qm74	5812	13	the	the	DT
cord-015021-pol2qm74	5812	14	Injury	Injury	NNP
cord-015021-pol2qm74	5812	15	Severity	Severity	NNP
cord-015021-pol2qm74	5812	16	Score	Score	NNP
cord-015021-pol2qm74	5812	17	(	(	-LRB-
cord-015021-pol2qm74	5812	18	ISS	ISS	NNP
cord-015021-pol2qm74	5812	19	)	)	-RRB-
cord-015021-pol2qm74	5812	20	.	.	.
cord-015021-pol2qm74	5813	1	Lidocaine	lidocaine	NN
cord-015021-pol2qm74	5813	2	is	be	VBZ
cord-015021-pol2qm74	5813	3	given	give	VBN
cord-015021-pol2qm74	5813	4	at	at	IN
cord-015021-pol2qm74	5813	5	a	a	DT
cord-015021-pol2qm74	5813	6	dose	dose	NN
cord-015021-pol2qm74	5813	7	of	of	IN
cord-015021-pol2qm74	5813	8	1	1	CD
cord-015021-pol2qm74	5813	9	mg	mg	NNP
cord-015021-pol2qm74	5813	10	/	/	SYM
cord-015021-pol2qm74	5813	11	kgBW	kgBW	NNP
cord-015021-pol2qm74	5813	12	over	over	IN
cord-015021-pol2qm74	5813	13	2	2	CD
cord-015021-pol2qm74	5813	14	rain	rain	NN
cord-015021-pol2qm74	5813	15	.	.	.
cord-015021-pol2qm74	5814	1	i.v	i.v	NNP
cord-015021-pol2qm74	5814	2	.	.	.
cord-015021-pol2qm74	5815	1	and	and	CC
cord-015021-pol2qm74	5815	2	is	be	VBZ
cord-015021-pol2qm74	5815	3	metabolized	metabolize	VBN
cord-015021-pol2qm74	5815	4	in	in	IN
cord-015021-pol2qm74	5815	5	the	the	DT
cord-015021-pol2qm74	5815	6	liver	liver	NN
cord-015021-pol2qm74	5815	7	by	by	IN
cord-015021-pol2qm74	5815	8	a	a	DT
cord-015021-pol2qm74	5815	9	cytochrome	cytochrome	NN
cord-015021-pol2qm74	5815	10	P-450	p-450	NN
cord-015021-pol2qm74	5815	11	mechanism	mechanism	NN
cord-015021-pol2qm74	5815	12	to	to	IN
cord-015021-pol2qm74	5815	13	monoethylglycinexylidide	monoethylglycinexylidide	NN
cord-015021-pol2qm74	5815	14	(	(	-LRB-
cord-015021-pol2qm74	5815	15	MEGX	MEGX	NNP
cord-015021-pol2qm74	5815	16	)	)	-RRB-
cord-015021-pol2qm74	5815	17	.	.	.
cord-015021-pol2qm74	5816	1	The	the	DT
cord-015021-pol2qm74	5816	2	metabolite	metabolite	NN
cord-015021-pol2qm74	5816	3	is	be	VBZ
cord-015021-pol2qm74	5816	4	measured	measure	VBN
cord-015021-pol2qm74	5816	5	by	by	IN
cord-015021-pol2qm74	5816	6	a	a	DT
cord-015021-pol2qm74	5816	7	fluorescence	fluorescence	NN
cord-015021-pol2qm74	5816	8	polarization	polarization	NN
cord-015021-pol2qm74	5816	9	immunoassay	immunoassay	JJ
cord-015021-pol2qm74	5816	10	.	.	.
cord-015021-pol2qm74	5817	1	Serial	serial	JJ
cord-015021-pol2qm74	5817	2	determinations	determination	NNS
cord-015021-pol2qm74	5817	3	of	of	IN
cord-015021-pol2qm74	5817	4	the	the	DT
cord-015021-pol2qm74	5817	5	test	test	NN
cord-015021-pol2qm74	5817	6	were	be	VBD
cord-015021-pol2qm74	5817	7	performed	perform	VBN
cord-015021-pol2qm74	5817	8	between	between	IN
cord-015021-pol2qm74	5817	9	the	the	DT
cord-015021-pol2qm74	5817	10	1	1	CD
cord-015021-pol2qm74	5817	11	~t	~t	NNPS
cord-015021-pol2qm74	5817	12	and	and	CC
cord-015021-pol2qm74	5817	13	the	the	DT
cord-015021-pol2qm74	5817	14	11	11	CD
cord-015021-pol2qm74	5817	15	~	~	CD
cord-015021-pol2qm74	5817	16	day	day	NN
cord-015021-pol2qm74	5817	17	after	after	IN
cord-015021-pol2qm74	5817	18	trauma	trauma	NN
cord-015021-pol2qm74	5817	19	and	and	CC
cord-015021-pol2qm74	5817	20	were	be	VBD
cord-015021-pol2qm74	5817	21	compared	compare	VBN
cord-015021-pol2qm74	5817	22	with	with	IN
cord-015021-pol2qm74	5817	23	other	other	JJ
cord-015021-pol2qm74	5817	24	liver	liver	NN
cord-015021-pol2qm74	5817	25	function	function	NN
cord-015021-pol2qm74	5817	26	tests	test	NNS
cord-015021-pol2qm74	5817	27	(	(	-LRB-
cord-015021-pol2qm74	5817	28	bilimbin	bilimbin	NNP
cord-015021-pol2qm74	5817	29	,	,	,
cord-015021-pol2qm74	5817	30	GLDH	GLDH	NNP
cord-015021-pol2qm74	5817	31	,	,	,
cord-015021-pol2qm74	5817	32	ALT	ALT	NNP
cord-015021-pol2qm74	5817	33	,	,	,
cord-015021-pol2qm74	5817	34	AST	AST	NNP
cord-015021-pol2qm74	5817	35	)	)	-RRB-
cord-015021-pol2qm74	5817	36	.	.	.
cord-015021-pol2qm74	5818	1	The	the	DT
cord-015021-pol2qm74	5818	2	systemic	systemic	JJ
cord-015021-pol2qm74	5818	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5818	4	response	response	NN
cord-015021-pol2qm74	5818	5	syndrome	syndrome	NN
cord-015021-pol2qm74	5818	6	(	(	-LRB-
cord-015021-pol2qm74	5818	7	SIRS	SIRS	NNP
cord-015021-pol2qm74	5818	8	)	)	-RRB-
cord-015021-pol2qm74	5818	9	is	be	VBZ
cord-015021-pol2qm74	5818	10	still	still	RB
cord-015021-pol2qm74	5818	11	a	a	DT
cord-015021-pol2qm74	5818	12	challenge	challenge	NN
cord-015021-pol2qm74	5818	13	concerning	concern	VBG
cord-015021-pol2qm74	5818	14	early	early	JJ
cord-015021-pol2qm74	5818	15	diagnosis	diagnosis	NN
cord-015021-pol2qm74	5818	16	,	,	,
cord-015021-pol2qm74	5818	17	therapy	therapy	NN
cord-015021-pol2qm74	5818	18	and	and	CC
cord-015021-pol2qm74	5818	19	prognosis	prognosis	NN
cord-015021-pol2qm74	5818	20	.	.	.
cord-015021-pol2qm74	5819	1	Therefore	therefore	RB
cord-015021-pol2qm74	5819	2	,	,	,
cord-015021-pol2qm74	5819	3	evaluation	evaluation	NN
cord-015021-pol2qm74	5819	4	of	of	IN
cord-015021-pol2qm74	5819	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5819	6	and	and	CC
cord-015021-pol2qm74	5819	7	disease	disease	NN
cord-015021-pol2qm74	5819	8	activity	activity	NN
cord-015021-pol2qm74	5819	9	becomes	become	VBZ
cord-015021-pol2qm74	5819	10	more	more	RBR
cord-015021-pol2qm74	5819	11	important	important	JJ
cord-015021-pol2qm74	5819	12	.	.	.
cord-015021-pol2qm74	5820	1	C	C	NNP
cord-015021-pol2qm74	5820	2	-	-	HYPH
cord-015021-pol2qm74	5820	3	reactive	reactive	JJ
cord-015021-pol2qm74	5820	4	protein	protein	NN
cord-015021-pol2qm74	5820	5	(	(	-LRB-
cord-015021-pol2qm74	5820	6	CRP	CRP	NNP
cord-015021-pol2qm74	5820	7	)	)	-RRB-
cord-015021-pol2qm74	5820	8	is	be	VBZ
cord-015021-pol2qm74	5820	9	a	a	DT
cord-015021-pol2qm74	5820	10	well	well	RB
cord-015021-pol2qm74	5820	11	established	establish	VBN
cord-015021-pol2qm74	5820	12	acute	acute	JJ
cord-015021-pol2qm74	5820	13	phase	phase	NN
cord-015021-pol2qm74	5820	14	protein	protein	NN
cord-015021-pol2qm74	5820	15	in	in	IN
cord-015021-pol2qm74	5820	16	chronic	chronic	JJ
cord-015021-pol2qm74	5820	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5820	18	diseases	disease	NNS
cord-015021-pol2qm74	5820	19	.	.	.
cord-015021-pol2qm74	5821	1	Recent	recent	JJ
cord-015021-pol2qm74	5821	2	reports	report	NNS
cord-015021-pol2qm74	5821	3	suggest	suggest	VBP
cord-015021-pol2qm74	5821	4	an	an	DT
cord-015021-pol2qm74	5821	5	induction	induction	NN
cord-015021-pol2qm74	5821	6	of	of	IN
cord-015021-pol2qm74	5821	7	CRP	CRP	NNP
cord-015021-pol2qm74	5821	8	by	by	IN
cord-015021-pol2qm74	5821	9	interteukin-6	interteukin-6	NNP
cord-015021-pol2qm74	5821	10	(	(	-LRB-
cord-015021-pol2qm74	5821	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	5821	12	)	)	-RRB-
cord-015021-pol2qm74	5821	13	,	,	,
cord-015021-pol2qm74	5821	14	a	a	DT
cord-015021-pol2qm74	5821	15	cytokine	cytokine	NN
cord-015021-pol2qm74	5821	16	involved	involve	VBN
cord-015021-pol2qm74	5821	17	in	in	IN
cord-015021-pol2qm74	5821	18	the	the	DT
cord-015021-pol2qm74	5821	19	mediator	mediator	NN
cord-015021-pol2qm74	5821	20	cascade	cascade	NN
cord-015021-pol2qm74	5821	21	of	of	IN
cord-015021-pol2qm74	5821	22	SIRS	SIRS	NNP
cord-015021-pol2qm74	5821	23	.	.	.
cord-015021-pol2qm74	5822	1	On	on	IN
cord-015021-pol2qm74	5822	2	the	the	DT
cord-015021-pol2qm74	5822	3	other	other	JJ
cord-015021-pol2qm74	5822	4	hand	hand	NN
cord-015021-pol2qm74	5822	5	,	,	,
cord-015021-pol2qm74	5822	6	tumornecmsisfactor	tumornecmsisfactor	NNP
cord-015021-pol2qm74	5822	7	alpha	alpha	NN
cord-015021-pol2qm74	5822	8	(	(	-LRB-
cord-015021-pol2qm74	5822	9	TNFcx	TNFcx	NNP
cord-015021-pol2qm74	5822	10	)	)	-RRB-
cord-015021-pol2qm74	5822	11	is	be	VBZ
cord-015021-pol2qm74	5822	12	a	a	DT
cord-015021-pol2qm74	5822	13	very	very	RB
cord-015021-pol2qm74	5822	14	early	early	RB
cord-015021-pol2qm74	5822	15	released	release	VBN
cord-015021-pol2qm74	5822	16	mediator	mediator	NN
cord-015021-pol2qm74	5822	17	in	in	IN
cord-015021-pol2qm74	5822	18	SIRS	SIRS	NNP
cord-015021-pol2qm74	5822	19	removed	remove	VBD
cord-015021-pol2qm74	5822	20	very	very	RB
cord-015021-pol2qm74	5822	21	rapidly	rapidly	RB
cord-015021-pol2qm74	5822	22	from	from	IN
cord-015021-pol2qm74	5822	23	circulation	circulation	NN
cord-015021-pol2qm74	5822	24	.	.	.
cord-015021-pol2qm74	5823	1	In	in	IN
cord-015021-pol2qm74	5823	2	addition	addition	NN
cord-015021-pol2qm74	5823	3	,	,	,
cord-015021-pol2qm74	5823	4	soluble	soluble	JJ
cord-015021-pol2qm74	5823	5	TNF	TNF	NNP
cord-015021-pol2qm74	5823	6	receptors	receptor	NNS
cord-015021-pol2qm74	5823	7	(	(	-LRB-
cord-015021-pol2qm74	5823	8	sTNFR~5	sTNFR~5	NNP
cord-015021-pol2qm74	5823	9	,	,	,
cord-015021-pol2qm74	5823	10	sTNFR75	sTNFR75	NNS
cord-015021-pol2qm74	5823	11	)	)	-RRB-
cord-015021-pol2qm74	5823	12	are	be	VBP
cord-015021-pol2qm74	5823	13	released	release	VBN
cord-015021-pol2qm74	5823	14	into	into	IN
cord-015021-pol2qm74	5823	15	circulation	circulation	NN
cord-015021-pol2qm74	5823	16	in	in	IN
cord-015021-pol2qm74	5823	17	the	the	DT
cord-015021-pol2qm74	5823	18	acute	acute	JJ
cord-015021-pol2qm74	5823	19	phase	phase	NN
cord-015021-pol2qm74	5823	20	response	response	NN
cord-015021-pol2qm74	5823	21	.	.	.
cord-015021-pol2qm74	5824	1	This	this	DT
cord-015021-pol2qm74	5824	2	study	study	NN
cord-015021-pol2qm74	5824	3	examines	examine	VBZ
cord-015021-pol2qm74	5824	4	the	the	DT
cord-015021-pol2qm74	5824	5	kinetics	kinetic	NNS
cord-015021-pol2qm74	5824	6	of	of	IN
cord-015021-pol2qm74	5824	7	five	five	CD
cord-015021-pol2qm74	5824	8	acute	acute	JJ
cord-015021-pol2qm74	5824	9	phase	phase	NN
cord-015021-pol2qm74	5824	10	proteins	protein	NNS
cord-015021-pol2qm74	5824	11	(	(	-LRB-
cord-015021-pol2qm74	5824	12	CRP	CRP	NNP
cord-015021-pol2qm74	5824	13	,	,	,
cord-015021-pol2qm74	5824	14	IL-6	IL-6	NNP
cord-015021-pol2qm74	5824	15	,	,	,
cord-015021-pol2qm74	5824	16	TNFot	TNFot	NNP
cord-015021-pol2qm74	5824	17	,	,	,
cord-015021-pol2qm74	5824	18	sTNFR55	stnfr55	CD
cord-015021-pol2qm74	5824	19	,	,	,
cord-015021-pol2qm74	5824	20	sTNFR75	stnfr75	CD
cord-015021-pol2qm74	5824	21	)	)	-RRB-
cord-015021-pol2qm74	5824	22	in	in	IN
cord-015021-pol2qm74	5824	23	patients	patient	NNS
cord-015021-pol2qm74	5824	24	suffering	suffer	VBG
cord-015021-pol2qm74	5824	25	from	from	IN
cord-015021-pol2qm74	5824	26	SIRS	SIRS	NNP
cord-015021-pol2qm74	5824	27	.	.	.
cord-015021-pol2qm74	5825	1	Eighteen	eighteen	CD
cord-015021-pol2qm74	5825	2	patients	patient	NNS
cord-015021-pol2qm74	5825	3	entered	enter	VBD
cord-015021-pol2qm74	5825	4	the	the	DT
cord-015021-pol2qm74	5825	5	study	study	NN
cord-015021-pol2qm74	5825	6	after	after	IN
cord-015021-pol2qm74	5825	7	diagnosis	diagnosis	NN
cord-015021-pol2qm74	5825	8	of	of	IN
cord-015021-pol2qm74	5825	9	SIRS	SIRS	NNP
cord-015021-pol2qm74	5825	10	.	.	.
cord-015021-pol2qm74	5826	1	Blood	blood	NN
cord-015021-pol2qm74	5826	2	samples	sample	NNS
cord-015021-pol2qm74	5826	3	were	be	VBD
cord-015021-pol2qm74	5826	4	drawn	draw	VBN
cord-015021-pol2qm74	5826	5	every	every	DT
cord-015021-pol2qm74	5826	6	six	six	CD
cord-015021-pol2qm74	5826	7	hours	hour	NNS
cord-015021-pol2qm74	5826	8	during	during	IN
cord-015021-pol2qm74	5826	9	the	the	DT
cord-015021-pol2qm74	5826	10	first	first	JJ
cord-015021-pol2qm74	5826	11	two	two	CD
cord-015021-pol2qm74	5826	12	days	day	NNS
cord-015021-pol2qm74	5826	13	and	and	CC
cord-015021-pol2qm74	5826	14	every	every	DT
cord-015021-pol2qm74	5826	15	twelve	twelve	CD
cord-015021-pol2qm74	5826	16	hours	hour	NNS
cord-015021-pol2qm74	5826	17	thereafter	thereafter	RB
cord-015021-pol2qm74	5826	18	.	.	.
cord-015021-pol2qm74	5827	1	CRP	CRP	NNP
cord-015021-pol2qm74	5827	2	was	be	VBD
cord-015021-pol2qm74	5827	3	measured	measure	VBN
cord-015021-pol2qm74	5827	4	in	in	IN
cord-015021-pol2qm74	5827	5	an	an	DT
cord-015021-pol2qm74	5827	6	routine	routine	JJ
cord-015021-pol2qm74	5827	7	turbimetric	turbimetric	NN
cord-015021-pol2qm74	5827	8	assay	assay	NN
cord-015021-pol2qm74	5827	9	.	.	.
cord-015021-pol2qm74	5828	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	5828	2	was	be	VBD
cord-015021-pol2qm74	5828	3	detected	detect	VBN
cord-015021-pol2qm74	5828	4	in	in	IN
cord-015021-pol2qm74	5828	5	an	an	DT
cord-015021-pol2qm74	5828	6	biological	biological	JJ
cord-015021-pol2qm74	5828	7	assay	assay	NN
cord-015021-pol2qm74	5828	8	using	use	VBG
cord-015021-pol2qm74	5828	9	the	the	DT
cord-015021-pol2qm74	5828	10	/	/	SYM
cord-015021-pol2qm74	5828	11	L-6	L-6	NNP
cord-015021-pol2qm74	5828	12	dependent	dependent	JJ
cord-015021-pol2qm74	5828	13	13-cell	13-cell	CD
cord-015021-pol2qm74	5828	14	line	line	NN
cord-015021-pol2qm74	5828	15	1313/29	1313/29	CD
cord-015021-pol2qm74	5828	16	.	.	.
cord-015021-pol2qm74	5829	1	Detection	detection	NN
cord-015021-pol2qm74	5829	2	of	of	IN
cord-015021-pol2qm74	5829	3	TNFc~	TNFc~	NNP
cord-015021-pol2qm74	5829	4	was	be	VBD
cord-015021-pol2qm74	5829	5	performed	perform	VBN
cord-015021-pol2qm74	5829	6	in	in	IN
cord-015021-pol2qm74	5829	7	an	an	DT
cord-015021-pol2qm74	5829	8	ELISA	ELISA	NNP
cord-015021-pol2qm74	5829	9	system	system	NN
cord-015021-pol2qm74	5829	10	using	use	VBG
cord-015021-pol2qm74	5829	11	a	a	DT
cord-015021-pol2qm74	5829	12	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	5829	13	antibody	antibody	NN
cord-015021-pol2qm74	5829	14	"	"	''
cord-015021-pol2qm74	5829	15	for	for	IN
cord-015021-pol2qm74	5829	16	TNFo~.	TNFo~.	NNP
cord-015021-pol2qm74	5829	17	Soluble	soluble	JJ
cord-015021-pol2qm74	5829	18	TNF	TNF	NNP
cord-015021-pol2qm74	5829	19	receptors	receptor	NNS
cord-015021-pol2qm74	5829	20	were	be	VBD
cord-015021-pol2qm74	5829	21	also	also	RB
cord-015021-pol2qm74	5829	22	measured	measure	VBN
cord-015021-pol2qm74	5829	23	by	by	IN
cord-015021-pol2qm74	5829	24	ELISA	ELISA	NNP
cord-015021-pol2qm74	5829	25	.	.	.
cord-015021-pol2qm74	5830	1	CRP	CRP	NNP
cord-015021-pol2qm74	5830	2	levels	level	NNS
cord-015021-pol2qm74	5830	3	were	be	VBD
cord-015021-pol2qm74	5830	4	elevated	elevate	VBN
cord-015021-pol2qm74	5830	5	(	(	-LRB-
cord-015021-pol2qm74	5830	6	>	>	NFP
cord-015021-pol2qm74	5830	7	10	10	CD
cord-015021-pol2qm74	5830	8	mg	mg	NNP
cord-015021-pol2qm74	5830	9	/	/	SYM
cord-015021-pol2qm74	5830	10	L	L	NNP
cord-015021-pol2qm74	5830	11	)	)	-RRB-
cord-015021-pol2qm74	5830	12	in	in	IN
cord-015021-pol2qm74	5830	13	all	all	DT
cord-015021-pol2qm74	5830	14	patients	patient	NNS
cord-015021-pol2qm74	5830	15	and	and	CC
cord-015021-pol2qm74	5830	16	at	at	IN
cord-015021-pol2qm74	5830	17	all	all	DT
cord-015021-pol2qm74	5830	18	time	time	NN
cord-015021-pol2qm74	5830	19	points	point	NNS
cord-015021-pol2qm74	5830	20	.	.	.
cord-015021-pol2qm74	5831	1	CRP	CRP	NNP
cord-015021-pol2qm74	5831	2	values	value	NNS
cord-015021-pol2qm74	5831	3	did	do	VBD
cord-015021-pol2qm74	5831	4	neither	neither	DT
cord-015021-pol2qm74	5831	5	differ	differ	VB
cord-015021-pol2qm74	5831	6	significantly	significantly	RB
cord-015021-pol2qm74	5831	7	in	in	IN
cord-015021-pol2qm74	5831	8	patients	patient	NNS
cord-015021-pol2qm74	5831	9	with	with	IN
cord-015021-pol2qm74	5831	10	(	(	-LRB-
cord-015021-pol2qm74	5831	11	143±33	143±33	CD
cord-015021-pol2qm74	5831	12	mg	mg	NNP
cord-015021-pol2qm74	5831	13	/	/	SYM
cord-015021-pol2qm74	5831	14	L	L	NNP
cord-015021-pol2qm74	5831	15	)	)	-RRB-
cord-015021-pol2qm74	5831	16	or	or	CC
cord-015021-pol2qm74	5831	17	without	without	IN
cord-015021-pol2qm74	5831	18	(	(	-LRB-
cord-015021-pol2qm74	5831	19	129a:39	129a:39	CD
cord-015021-pol2qm74	5831	20	)	)	-RRB-
cord-015021-pol2qm74	5831	21	multiple	multiple	JJ
cord-015021-pol2qm74	5831	22	organ	organ	NN
cord-015021-pol2qm74	5831	23	failure	failure	NN
cord-015021-pol2qm74	5831	24	(	(	-LRB-
cord-015021-pol2qm74	5831	25	MOF	MOF	NNP
cord-015021-pol2qm74	5831	26	)	)	-RRB-
cord-015021-pol2qm74	5831	27	nor	nor	CC
cord-015021-pol2qm74	5831	28	in	in	IN
cord-015021-pol2qm74	5831	29	survivors	survivor	NNS
cord-015021-pol2qm74	5831	30	(	(	-LRB-
cord-015021-pol2qm74	5831	31	133±41	133±41	CD
cord-015021-pol2qm74	5831	32	)	)	-RRB-
cord-015021-pol2qm74	5831	33	or	or	CC
cord-015021-pol2qm74	5831	34	non	non	NNS
cord-015021-pol2qm74	5831	35	-	-	NNS
cord-015021-pol2qm74	5831	36	survivors	survivor	NNS
cord-015021-pol2qm74	5831	37	(	(	-LRB-
cord-015021-pol2qm74	5831	38	147	147	CD
cord-015021-pol2qm74	5831	39	:	:	:
cord-015021-pol2qm74	5831	40	t:44	t:44	CD
cord-015021-pol2qm74	5831	41	)	)	-RRB-
cord-015021-pol2qm74	5831	42	.	.	.
cord-015021-pol2qm74	5832	1	In	in	IN
cord-015021-pol2qm74	5832	2	contrast	contrast	NN
cord-015021-pol2qm74	5832	3	,	,	,
cord-015021-pol2qm74	5832	4	1L-6	1l-6	CD
cord-015021-pol2qm74	5832	5	was	be	VBD
cord-015021-pol2qm74	5832	6	elevated	elevate	VBN
cord-015021-pol2qm74	5832	7	in	in	IN
cord-015021-pol2qm74	5832	8	patients	patient	NNS
cord-015021-pol2qm74	5832	9	wilh	wilh	NNP
cord-015021-pol2qm74	5832	10	MOF	MOF	NNP
cord-015021-pol2qm74	5832	11	(	(	-LRB-
cord-015021-pol2qm74	5832	12	mean	mean	VBP
cord-015021-pol2qm74	5832	13	740	740	CD
cord-015021-pol2qm74	5832	14	pg	pg	NN
cord-015021-pol2qm74	5832	15	/	/	SYM
cord-015021-pol2qm74	5832	16	ml	ml	NN
cord-015021-pol2qm74	5832	17	,	,	,
cord-015021-pol2qm74	5832	18	range	range	VBP
cord-015021-pol2qm74	5832	19	0	0	CD
cord-015021-pol2qm74	5832	20	-	-	HYPH
cord-015021-pol2qm74	5832	21	8900	8900	CD
cord-015021-pol2qm74	5832	22	pg	pg	NN
cord-015021-pol2qm74	5832	23	/	/	SYM
cord-015021-pol2qm74	5832	24	ml	ml	NNP
cord-015021-pol2qm74	5832	25	)	)	-RRB-
cord-015021-pol2qm74	5832	26	.	.	.
cord-015021-pol2qm74	5833	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	5833	2	levels	level	NNS
cord-015021-pol2qm74	5833	3	correlated	correlate	VBN
cord-015021-pol2qm74	5833	4	especially	especially	RB
cord-015021-pol2qm74	5833	5	with	with	IN
cord-015021-pol2qm74	5833	6	lung	lung	NN
cord-015021-pol2qm74	5833	7	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5833	8	.	.	.
cord-015021-pol2qm74	5834	1	TNF(x	tnf(x	NN
cord-015021-pol2qm74	5834	2	levels	level	NNS
cord-015021-pol2qm74	5834	3	were	be	VBD
cord-015021-pol2qm74	5834	4	consistently	consistently	RB
cord-015021-pol2qm74	5834	5	elevated	elevate	VBN
cord-015021-pol2qm74	5834	6	in	in	IN
cord-015021-pol2qm74	5834	7	patients	patient	NNS
cord-015021-pol2qm74	5834	8	with	with	IN
cord-015021-pol2qm74	5834	9	MOF	MOF	NNP
cord-015021-pol2qm74	5834	10	.	.	.
cord-015021-pol2qm74	5835	1	CRP	CRP	NNP
cord-015021-pol2qm74	5835	2	,	,	,
cord-015021-pol2qm74	5835	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	5835	4	and	and	CC
cord-015021-pol2qm74	5835	5	TNFoc	TNFoc	NNP
cord-015021-pol2qm74	5835	6	did	do	VBD
cord-015021-pol2qm74	5835	7	not	not	RB
cord-015021-pol2qm74	5835	8	correlate	correlate	VB
cord-015021-pol2qm74	5835	9	with	with	IN
cord-015021-pol2qm74	5835	10	each	each	DT
cord-015021-pol2qm74	5835	11	other	other	JJ
cord-015021-pol2qm74	5835	12	.	.	.
cord-015021-pol2qm74	5836	1	In	in	IN
cord-015021-pol2qm74	5836	2	contrast	contrast	NN
cord-015021-pol2qm74	5836	3	,	,	,
cord-015021-pol2qm74	5836	4	levels	level	NNS
cord-015021-pol2qm74	5836	5	for	for	IN
cord-015021-pol2qm74	5836	6	both	both	DT
cord-015021-pol2qm74	5836	7	sTNFR	stnfr	RB
cord-015021-pol2qm74	5836	8	showed	show	VBD
cord-015021-pol2qm74	5836	9	a	a	DT
cord-015021-pol2qm74	5836	10	positive	positive	JJ
cord-015021-pol2qm74	5836	11	correlation	correlation	NN
cord-015021-pol2qm74	5836	12	(	(	-LRB-
cord-015021-pol2qm74	5836	13	r=0.7	r=0.7	NNP
cord-015021-pol2qm74	5836	14	)	)	-RRB-
cord-015021-pol2qm74	5836	15	.	.	.
cord-015021-pol2qm74	5837	1	Patients	patient	NNS
cord-015021-pol2qm74	5837	2	could	could	MD
cord-015021-pol2qm74	5837	3	be	be	VB
cord-015021-pol2qm74	5837	4	divided	divide	VBN
cord-015021-pol2qm74	5837	5	into	into	IN
cord-015021-pol2qm74	5837	6	two	two	CD
cord-015021-pol2qm74	5837	7	groups	group	NNS
cord-015021-pol2qm74	5837	8	by	by	IN
cord-015021-pol2qm74	5837	9	values	value	NNS
cord-015021-pol2qm74	5837	10	for	for	IN
cord-015021-pol2qm74	5837	11	sTNFR~5	sTNFR~5	NNP
cord-015021-pol2qm74	5837	12	and	and	CC
cord-015021-pol2qm74	5837	13	sTNFR75	sTNFR75	NNS
cord-015021-pol2qm74	5837	14	:	:	:
cord-015021-pol2qm74	5838	1	The	the	DT
cord-015021-pol2qm74	5838	2	group	group	NN
cord-015021-pol2qm74	5838	3	with	with	IN
cord-015021-pol2qm74	5838	4	higher	high	JJR
cord-015021-pol2qm74	5838	5	soluble	soluble	JJ
cord-015021-pol2qm74	5838	6	TNF	TNF	NNP
cord-015021-pol2qm74	5838	7	receptor	receptor	NN
cord-015021-pol2qm74	5838	8	levels	level	NNS
cord-015021-pol2qm74	5838	9	showed	show	VBD
cord-015021-pol2qm74	5838	10	increasing	increase	VBG
cord-015021-pol2qm74	5838	11	values	value	NNS
cord-015021-pol2qm74	5838	12	combined	combine	VBN
cord-015021-pol2qm74	5838	13	with	with	IN
cord-015021-pol2qm74	5838	14	a	a	DT
cord-015021-pol2qm74	5838	15	poor	poor	JJ
cord-015021-pol2qm74	5838	16	prognosis	prognosis	NN
cord-015021-pol2qm74	5838	17	.	.	.
cord-015021-pol2qm74	5839	1	The	the	DT
cord-015021-pol2qm74	5839	2	group	group	NN
cord-015021-pol2qm74	5839	3	with	with	IN
cord-015021-pol2qm74	5839	4	lower	low	JJR
cord-015021-pol2qm74	5839	5	levels	level	NNS
cord-015021-pol2qm74	5839	6	of	of	IN
cord-015021-pol2qm74	5839	7	soluble	soluble	JJ
cord-015021-pol2qm74	5839	8	TNF	TNF	NNP
cord-015021-pol2qm74	5839	9	receptor	receptor	NN
cord-015021-pol2qm74	5839	10	consisted	consist	VBD
cord-015021-pol2qm74	5839	11	of	of	IN
cord-015021-pol2qm74	5839	12	patients	patient	NNS
cord-015021-pol2qm74	5839	13	surviving	survive	VBG
cord-015021-pol2qm74	5839	14	MOF	MOF	NNP
cord-015021-pol2qm74	5839	15	or	or	CC
cord-015021-pol2qm74	5839	16	without	without	IN
cord-015021-pol2qm74	5839	17	MOF	MOF	NNP
cord-015021-pol2qm74	5839	18	.	.	.
cord-015021-pol2qm74	5840	1	In	in	IN
cord-015021-pol2qm74	5840	2	conclusion	conclusion	NN
cord-015021-pol2qm74	5840	3	,	,	,
cord-015021-pol2qm74	5840	4	CRP	CRP	NNP
cord-015021-pol2qm74	5840	5	does	do	VBZ
cord-015021-pol2qm74	5840	6	not	not	RB
cord-015021-pol2qm74	5840	7	monitor	monitor	VB
cord-015021-pol2qm74	5840	8	the	the	DT
cord-015021-pol2qm74	5840	9	course	course	NN
cord-015021-pol2qm74	5840	10	of	of	IN
cord-015021-pol2qm74	5840	11	SIRS	SIRS	NNP
cord-015021-pol2qm74	5840	12	adequately	adequately	RB
cord-015021-pol2qm74	5840	13	.	.	.
cord-015021-pol2qm74	5841	1	In	in	IN
cord-015021-pol2qm74	5841	2	contrast	contrast	NN
cord-015021-pol2qm74	5841	3	,	,	,
cord-015021-pol2qm74	5841	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	5841	5	correlates	correlate	VBZ
cord-015021-pol2qm74	5841	6	with	with	IN
cord-015021-pol2qm74	5841	7	MOF	MOF	NNP
cord-015021-pol2qm74	5841	8	and	and	CC
cord-015021-pol2qm74	5841	9	episodes	episode	NNS
cord-015021-pol2qm74	5841	10	of	of	IN
cord-015021-pol2qm74	5841	11	high	high	JJ
cord-015021-pol2qm74	5841	12	disease	disease	NN
cord-015021-pol2qm74	5841	13	activity	activity	NN
cord-015021-pol2qm74	5841	14	.	.	.
cord-015021-pol2qm74	5842	1	High	high	JJ
cord-015021-pol2qm74	5842	2	sTNFR	stnfr	NN
cord-015021-pol2qm74	5842	3	levels	level	NNS
cord-015021-pol2qm74	5842	4	may	may	MD
cord-015021-pol2qm74	5842	5	indicate	indicate	VB
cord-015021-pol2qm74	5842	6	poor	poor	JJ
cord-015021-pol2qm74	5842	7	prognosis	prognosis	NN
cord-015021-pol2qm74	5842	8	.	.	.
cord-015021-pol2qm74	5843	1	Klinik	Klinik	NNP
cord-015021-pol2qm74	5843	2	F0r	F0r	NNP
cord-015021-pol2qm74	5844	1	An	an	DT
cord-015021-pol2qm74	5844	2	/	/	SYM
cord-015021-pol2qm74	5844	3	isthesiologie	isthesiologie	NN
cord-015021-pol2qm74	5844	4	and	and	CC
cord-015021-pol2qm74	5844	5	Operative	Operative	NNP
cord-015021-pol2qm74	5844	6	Intensivmedizin	Intensivmedizin	NNP
cord-015021-pol2qm74	5844	7	der	der	NNP
cord-015021-pol2qm74	5844	8	CAU	CAU	NNP
cord-015021-pol2qm74	5844	9	Kiel	Kiel	NNP
cord-015021-pol2qm74	5844	10	,	,	,
cord-015021-pol2qm74	5844	11	Schwanenweg	Schwanenweg	NNP
cord-015021-pol2qm74	5844	12	21	21	CD
cord-015021-pol2qm74	5844	13	,	,	,
cord-015021-pol2qm74	5844	14	24105	24105	CD
cord-015021-pol2qm74	5844	15	Kiei	Kiei	NNP
cord-015021-pol2qm74	5844	16	,	,	,
cord-015021-pol2qm74	5844	17	Germany	Germany	NNP
cord-015021-pol2qm74	5844	18	.	.	.
cord-015021-pol2qm74	5845	1	Ch	Ch	NNP
cord-015021-pol2qm74	5845	2	.	.	.
cord-015021-pol2qm74	5846	1	Waydhas	Waydhas	NNP
cord-015021-pol2qm74	5846	2	,	,	,
cord-015021-pol2qm74	5846	3	MD	MD	NNP
cord-015021-pol2qm74	5846	4	;	;	:
cord-015021-pol2qm74	5846	5	D.	D.	NNP
cord-015021-pol2qm74	5846	6	Nast	Nast	NNP
cord-015021-pol2qm74	5846	7	-	-	HYPH
cord-015021-pol2qm74	5846	8	Kolb	Kolb	NNP
cord-015021-pol2qm74	5846	9	,	,	,
cord-015021-pol2qm74	5846	10	ivID	ivid	NN
cord-015021-pol2qm74	5846	11	;	;	:
cord-015021-pol2qm74	5846	12	M.	M.	NNP
cord-015021-pol2qm74	5846	13	Jochum	Jochum	NNP
cord-015021-pol2qm74	5846	14	,	,	,
cord-015021-pol2qm74	5846	15	Phi	Phi	NNP
cord-015021-pol2qm74	5846	16	)	)	-RRB-
cord-015021-pol2qm74	5846	17	;	;	:
cord-015021-pol2qm74	5846	18	L.	L.	NNP
cord-015021-pol2qm74	5846	19	Schweiberer	Schweiberer	NNP
cord-015021-pol2qm74	5846	20	,	,	,
cord-015021-pol2qm74	5846	21	MI	MI	NNP
cord-015021-pol2qm74	5847	1	)	)	-RRB-
cord-015021-pol2qm74	5847	2	Objective	objective	NN
cord-015021-pol2qm74	5847	3	:	:	:
cord-015021-pol2qm74	5847	4	To	to	TO
cord-015021-pol2qm74	5847	5	evaluate	evaluate	VB
cord-015021-pol2qm74	5847	6	the	the	DT
cord-015021-pol2qm74	5847	7	irfflarranatory	irfflarranatory	NNP
cord-015021-pol2qm74	5847	8	response	response	NN
cord-015021-pol2qm74	5847	9	after	after	IN
cord-015021-pol2qm74	5847	10	different	different	JJ
cord-015021-pol2qm74	5847	11	types	type	NNS
cord-015021-pol2qm74	5847	12	of	of	IN
cord-015021-pol2qm74	5847	13	orthopedic	orthopedic	NN
cord-015021-pol2qm74	5847	14	operations	operation	NNS
cord-015021-pol2qm74	5847	15	and	and	CC
cord-015021-pol2qm74	5847	16	compare	compare	VB
cord-015021-pol2qm74	5847	17	them	-PRON-	PRP
cord-015021-pol2qm74	5847	18	with	with	IN
cord-015021-pol2qm74	5847	19	the	the	DT
cord-015021-pol2qm74	5847	20	systemic	systemic	JJ
cord-015021-pol2qm74	5847	21	effects	effect	NNS
cord-015021-pol2qm74	5847	22	of	of	IN
cord-015021-pol2qm74	5847	23	accidental	accidental	JJ
cord-015021-pol2qm74	5847	24	trauma	trauma	NN
cord-015021-pol2qm74	5847	25	of	of	IN
cord-015021-pol2qm74	5847	26	varying	vary	VBG
cord-015021-pol2qm74	5847	27	severity	severity	NN
cord-015021-pol2qm74	5847	28	.	.	.
cord-015021-pol2qm74	5848	1	Patients	patient	NNS
cord-015021-pol2qm74	5848	2	:	:	:
cord-015021-pol2qm74	5848	3	In	in	IN
cord-015021-pol2qm74	5848	4	135	135	CD
cord-015021-pol2qm74	5848	5	consecutive	consecutive	JJ
cord-015021-pol2qm74	5848	6	patients	patient	NNS
cord-015021-pol2qm74	5848	7	with	with	IN
cord-015021-pol2qm74	5848	8	multiple	multiple	JJ
cord-015021-pol2qm74	5848	9	injuries	injury	NNS
cord-015021-pol2qm74	5848	10	(	(	-LRB-
cord-015021-pol2qm74	5848	11	ISS	ISS	NNP
cord-015021-pol2qm74	5848	12	40.6	40.6	CD
cord-015021-pol2qm74	5848	13	)	)	-RRB-
cord-015021-pol2qm74	5849	1	the	the	DT
cord-015021-pol2qm74	5849	2	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5849	3	response	response	NN
cord-015021-pol2qm74	5849	4	to	to	IN
cord-015021-pol2qm74	5849	5	trauma	trauma	NN
cord-015021-pol2qm74	5849	6	was	be	VBD
cord-015021-pol2qm74	5849	7	prospectively	prospectively	RB
cord-015021-pol2qm74	5849	8	studied	study	VBN
cord-015021-pol2qm74	5849	9	.	.	.
cord-015021-pol2qm74	5850	1	The	the	DT
cord-015021-pol2qm74	5850	2	patients	patient	NNS
cord-015021-pol2qm74	5850	3	were	be	VBD
cord-015021-pol2qm74	5850	4	divided	divide	VBN
cord-015021-pol2qm74	5850	5	into	into	IN
cord-015021-pol2qm74	5850	6	4	4	CD
cord-015021-pol2qm74	5850	7	groups	group	NNS
cord-015021-pol2qm74	5850	8	according	accord	VBG
cord-015021-pol2qm74	5850	9	to	to	IN
cord-015021-pol2qm74	5850	10	their	-PRON-	PRP$
cord-015021-pol2qm74	5850	11	ISS	ISS	NNP
cord-015021-pol2qm74	5850	12	points	point	NNS
cord-015021-pol2qm74	5850	13	.	.	.
cord-015021-pol2qm74	5851	1	Additionally	additionally	RB
cord-015021-pol2qm74	5851	2	,	,	,
cord-015021-pol2qm74	5851	3	the	the	DT
cord-015021-pol2qm74	5851	4	alterations	alteration	NNS
cord-015021-pol2qm74	5851	5	after	after	IN
cord-015021-pol2qm74	5851	6	79	79	CD
cord-015021-pol2qm74	5851	7	secondary	secondary	JJ
cord-015021-pol2qm74	5851	8	operations	operation	NNS
cord-015021-pol2qm74	5851	9	(	(	-LRB-
cord-015021-pol2qm74	5851	10	>	>	NFP
cord-015021-pol2qm74	5851	11	24	24	CD
cord-015021-pol2qm74	5851	12	hr	hr	NN
cord-015021-pol2qm74	5851	13	)	)	-RRB-
cord-015021-pol2qm74	5851	14	were	be	VBD
cord-015021-pol2qm74	5851	15	determined	determine	VBN
cord-015021-pol2qm74	5851	16	(	(	-LRB-
cord-015021-pol2qm74	5851	17	msteosynthesis	msteosynthesis	NN
cord-015021-pol2qm74	5851	18	of	of	IN
cord-015021-pol2qm74	5851	19	the	the	DT
cord-015021-pol2qm74	5851	20	femur	femur	NN
cord-015021-pol2qm74	5851	21	(	(	-LRB-
cord-015021-pol2qm74	5851	22	n=28	n=28	RB
cord-015021-pol2qm74	5851	23	)	)	-RRB-
cord-015021-pol2qm74	5851	24	,	,	,
cord-015021-pol2qm74	5851	25	pelvic	pelvic	JJ
cord-015021-pol2qm74	5851	26	girdle	girdle	NN
cord-015021-pol2qm74	5851	27	(	(	-LRB-
cord-015021-pol2qm74	5851	28	n	n	NN
cord-015021-pol2qm74	5851	29	=	=	SYM
cord-015021-pol2qm74	5851	30	ll	ll	NNP
cord-015021-pol2qm74	5851	31	)	)	-RRB-
cord-015021-pol2qm74	5851	32	and	and	CC
cord-015021-pol2qm74	5851	33	spine	spine	NN
cord-015021-pol2qm74	5851	34	(	(	-LRB-
cord-015021-pol2qm74	5851	35	n=8	n=8	NN
cord-015021-pol2qm74	5851	36	)	)	-RRB-
cord-015021-pol2qm74	5851	37	,	,	,
cord-015021-pol2qm74	5851	38	facial	facial	JJ
cord-015021-pol2qm74	5851	39	reconstruction	reconstruction	NN
cord-015021-pol2qm74	5851	40	(	(	-LRB-
cord-015021-pol2qm74	5851	41	n=13	n=13	NNP
cord-015021-pol2qm74	5851	42	)	)	-RRB-
cord-015021-pol2qm74	5851	43	,	,	,
cord-015021-pol2qm74	5851	44	smaller	small	JJR
cord-015021-pol2qm74	5851	45	osteosynthesis	osteosynthesis	NNP
cord-015021-pol2qm74	5851	46	(	(	-LRB-
cord-015021-pol2qm74	5851	47	n=13	n=13	NNP
cord-015021-pol2qm74	5851	48	)	)	-RRB-
cord-015021-pol2qm74	5851	49	and	and	CC
cord-015021-pol2qm74	5851	50	others	other	NNS
cord-015021-pol2qm74	5851	51	(	(	-LRB-
cord-015021-pol2qm74	5851	52	n=6	n=6	NNP
cord-015021-pol2qm74	5851	53	)	)	-RRB-
cord-015021-pol2qm74	5851	54	)	)	-RRB-
cord-015021-pol2qm74	5851	55	.	.	.
cord-015021-pol2qm74	5852	1	Methods	method	NNS
cord-015021-pol2qm74	5852	2	:	:	:
cord-015021-pol2qm74	5852	3	Specific	specific	JJ
cord-015021-pol2qm74	5852	4	and	and	CC
cord-015021-pol2qm74	5852	5	unspecific	unspecific	JJ
cord-015021-pol2qm74	5852	6	parameters	parameter	NNS
cord-015021-pol2qm74	5852	7	of	of	IN
cord-015021-pol2qm74	5852	8	the	the	DT
cord-015021-pol2qm74	5852	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5852	10	response	response	NN
cord-015021-pol2qm74	5852	11	were	be	VBD
cord-015021-pol2qm74	5852	12	determined	determine	VBN
cord-015021-pol2qm74	5852	13	in	in	IN
cord-015021-pol2qm74	5852	14	the	the	DT
cord-015021-pol2qm74	5852	15	trauma	trauma	NN
cord-015021-pol2qm74	5852	16	patients	patient	NNS
cord-015021-pol2qm74	5852	17	every	every	DT
cord-015021-pol2qm74	5852	18	6	6	CD
cord-015021-pol2qm74	5852	19	h	h	NN
cord-015021-pol2qm74	5852	20	,	,	,
cord-015021-pol2qm74	5852	21	beginning	begin	VBG
cord-015021-pol2qm74	5852	22	on	on	IN
cord-015021-pol2qm74	5852	23	admission	admission	NN
cord-015021-pol2qm74	5852	24	of	of	IN
cord-015021-pol2qm74	5852	25	the	the	DT
cord-015021-pol2qm74	5852	26	patient	patient	NN
cord-015021-pol2qm74	5852	27	to	to	IN
cord-015021-pol2qm74	5852	28	the	the	DT
cord-015021-pol2qm74	5852	29	emergency	emergency	NN
cord-015021-pol2qm74	5852	30	room	room	NN
cord-015021-pol2qm74	5852	31	for	for	IN
cord-015021-pol2qm74	5852	32	a	a	DT
cord-015021-pol2qm74	5852	33	period	period	NN
cord-015021-pol2qm74	5852	34	of	of	IN
cord-015021-pol2qm74	5852	35	48	48	CD
cord-015021-pol2qm74	5852	36	hr	hr	NN
cord-015021-pol2qm74	5852	37	,	,	,
cord-015021-pol2qm74	5852	38	and	and	CC
cord-015021-pol2qm74	5852	39	in	in	IN
cord-015021-pol2qm74	5852	40	the	the	DT
cord-015021-pol2qm74	5852	41	operative	operative	JJ
cord-015021-pol2qm74	5852	42	patients	patient	NNS
cord-015021-pol2qm74	5852	43	on	on	IN
cord-015021-pol2qm74	5852	44	the	the	DT
cord-015021-pol2qm74	5852	45	morning	morning	NN
cord-015021-pol2qm74	5852	46	of	of	IN
cord-015021-pol2qm74	5852	47	the	the	DT
cord-015021-pol2qm74	5852	48	operation	operation	NN
cord-015021-pol2qm74	5852	49	,	,	,
cord-015021-pol2qm74	5852	50	at	at	IN
cord-015021-pol2qm74	5852	51	the	the	DT
cord-015021-pol2qm74	5852	52	end	end	NN
cord-015021-pol2qm74	5852	53	of	of	IN
cord-015021-pol2qm74	5852	54	the	the	DT
cord-015021-pol2qm74	5852	55	procedure	procedure	NN
cord-015021-pol2qm74	5852	56	and	and	CC
cord-015021-pol2qm74	5852	57	every	every	DT
cord-015021-pol2qm74	5852	58	6	6	CD
cord-015021-pol2qm74	5852	59	hr	hr	NN
cord-015021-pol2qm74	5852	60	during	during	IN
cord-015021-pol2qm74	5852	61	the	the	DT
cord-015021-pol2qm74	5852	62	first	first	JJ
cord-015021-pol2qm74	5852	63	two	two	CD
cord-015021-pol2qm74	5852	64	days	day	NNS
cord-015021-pol2qm74	5852	65	.	.	.
cord-015021-pol2qm74	5853	1	Results	result	NNS
cord-015021-pol2qm74	5853	2	:	:	:
cord-015021-pol2qm74	5854	1	Lactate	lactate	NN
cord-015021-pol2qm74	5854	2	,	,	,
cord-015021-pol2qm74	5854	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5854	4	elastase	elastase	NN
cord-015021-pol2qm74	5854	5	,	,	,
cord-015021-pol2qm74	5854	6	heart	heart	NN
cord-015021-pol2qm74	5854	7	rate	rate	NN
cord-015021-pol2qm74	5854	8	,	,	,
cord-015021-pol2qm74	5854	9	pO2	pO2	NNP
cord-015021-pol2qm74	5854	10	/	/	SYM
cord-015021-pol2qm74	5854	11	FiO2-ratio	FiO2-ratio	NNP
cord-015021-pol2qm74	5854	12	,	,	,
cord-015021-pol2qm74	5854	13	and	and	CC
cord-015021-pol2qm74	5854	14	other	other	JJ
cord-015021-pol2qm74	5854	15	parameters	parameter	NNS
cord-015021-pol2qm74	5854	16	discriminated	discriminate	VBN
cord-015021-pol2qm74	5854	17	significantly	significantly	RB
cord-015021-pol2qm74	5854	18	between	between	IN
cord-015021-pol2qm74	5854	19	the	the	DT
cord-015021-pol2qm74	5854	20	4	4	CD
cord-015021-pol2qm74	5854	21	injury	injury	NN
cord-015021-pol2qm74	5854	22	severity	severity	NN
cord-015021-pol2qm74	5854	23	groups	group	NNS
cord-015021-pol2qm74	5854	24	during	during	IN
cord-015021-pol2qm74	5854	25	the	the	DT
cord-015021-pol2qm74	5854	26	first	first	JJ
cord-015021-pol2qm74	5854	27	48	48	CD
cord-015021-pol2qm74	5854	28	hr	hr	NN
cord-015021-pol2qm74	5854	29	(	(	-LRB-
cord-015021-pol2qm74	5854	30	Kruskal	Kruskal	NNP
cord-015021-pol2qm74	5854	31	-	-	HYPH
cord-015021-pol2qm74	5854	32	Wallis	Wallis	NNP
cord-015021-pol2qm74	5854	33	-	-	HYPH
cord-015021-pol2qm74	5854	34	test	test	NN
cord-015021-pol2qm74	5854	35	,	,	,
cord-015021-pol2qm74	5854	36	p<.05	p<.05	NNP
cord-015021-pol2qm74	5854	37	)	)	-RRB-
cord-015021-pol2qm74	5854	38	.	.	.
cord-015021-pol2qm74	5855	1	The	the	DT
cord-015021-pol2qm74	5855	2	degree	degree	NN
cord-015021-pol2qm74	5855	3	of	of	IN
cord-015021-pol2qm74	5855	4	postoperative	postoperative	JJ
cord-015021-pol2qm74	5855	5	changes	change	NNS
cord-015021-pol2qm74	5855	6	differed	differ	VBD
cord-015021-pol2qm74	5855	7	significantly	significantly	RB
cord-015021-pol2qm74	5855	8	(	(	-LRB-
cord-015021-pol2qm74	5855	9	Kmskal	Kmskal	NNP
cord-015021-pol2qm74	5855	10	-	-	HYPH
cord-015021-pol2qm74	5855	11	Wallis	Wallis	NNP
cord-015021-pol2qm74	5855	12	-	-	HYPH
cord-015021-pol2qm74	5855	13	test	test	NN
cord-015021-pol2qm74	5855	14	,	,	,
cord-015021-pol2qm74	5855	15	p<.05	p<.05	NNP
cord-015021-pol2qm74	5855	16	)	)	-RRB-
cord-015021-pol2qm74	5855	17	between	between	IN
cord-015021-pol2qm74	5855	18	the	the	DT
cord-015021-pol2qm74	5855	19	5	5	CD
cord-015021-pol2qm74	5855	20	types	type	NNS
cord-015021-pol2qm74	5855	21	of	of	IN
cord-015021-pol2qm74	5855	22	operations	operation	NNS
cord-015021-pol2qm74	5855	23	for	for	IN
cord-015021-pol2qm74	5855	24	lactate	lactate	NN
cord-015021-pol2qm74	5855	25	,	,	,
cord-015021-pol2qm74	5855	26	heart	heart	NN
cord-015021-pol2qm74	5855	27	rate	rate	NN
cord-015021-pol2qm74	5855	28	,	,	,
cord-015021-pol2qm74	5855	29	pO2	pO2	NNP
cord-015021-pol2qm74	5855	30	/	/	SYM
cord-015021-pol2qm74	5855	31	FiO2-ratio	FiO2-ratio	NNP
cord-015021-pol2qm74	5855	32	,	,	,
cord-015021-pol2qm74	5855	33	nitrogen	nitrogen	NN
cord-015021-pol2qm74	5855	34	excretion	excretion	NN
cord-015021-pol2qm74	5855	35	and	and	CC
cord-015021-pol2qm74	5855	36	showed	show	VBD
cord-015021-pol2qm74	5855	37	a	a	DT
cord-015021-pol2qm74	5855	38	strong	strong	JJ
cord-015021-pol2qm74	5855	39	discriminating	discriminating	JJ
cord-015021-pol2qm74	5855	40	tendency	tendency	NN
cord-015021-pol2qm74	5855	41	for	for	IN
cord-015021-pol2qm74	5855	42	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5855	43	elastase	elastase	NN
cord-015021-pol2qm74	5855	44	and	and	CC
cord-015021-pol2qm74	5855	45	C	c	NN
cord-015021-pol2qm74	5855	46	-	-	HYPH
cord-015021-pol2qm74	5855	47	reactive	reactive	JJ
cord-015021-pol2qm74	5855	48	protein	protein	NN
cord-015021-pol2qm74	5855	49	.	.	.
cord-015021-pol2qm74	5856	1	The	the	DT
cord-015021-pol2qm74	5856	2	extent	extent	NN
cord-015021-pol2qm74	5856	3	of	of	IN
cord-015021-pol2qm74	5856	4	changes	change	NNS
cord-015021-pol2qm74	5856	5	were	be	VBD
cord-015021-pol2qm74	5856	6	highest	high	JJS
cord-015021-pol2qm74	5856	7	after	after	IN
cord-015021-pol2qm74	5856	8	operations	operation	NNS
cord-015021-pol2qm74	5856	9	of	of	IN
cord-015021-pol2qm74	5856	10	the	the	DT
cord-015021-pol2qm74	5856	11	pelvic	pelvic	JJ
cord-015021-pol2qm74	5856	12	girdle	girdle	NN
cord-015021-pol2qm74	5856	13	,	,	,
cord-015021-pol2qm74	5856	14	followed	follow	VBN
cord-015021-pol2qm74	5856	15	by	by	IN
cord-015021-pol2qm74	5856	16	procedures	procedure	NNS
cord-015021-pol2qm74	5856	17	on	on	IN
cord-015021-pol2qm74	5856	18	the	the	DT
cord-015021-pol2qm74	5856	19	femur	femur	NN
cord-015021-pol2qm74	5856	20	,	,	,
cord-015021-pol2qm74	5856	21	spine	spine	NN
cord-015021-pol2qm74	5856	22	,	,	,
cord-015021-pol2qm74	5856	23	smaller	small	JJR
cord-015021-pol2qm74	5856	24	bones	bone	NNS
cord-015021-pol2qm74	5856	25	,	,	,
cord-015021-pol2qm74	5856	26	and	and	CC
cord-015021-pol2qm74	5856	27	the	the	DT
cord-015021-pol2qm74	5856	28	facial	facial	JJ
cord-015021-pol2qm74	5856	29	region	region	NN
cord-015021-pol2qm74	5856	30	.	.	.
cord-015021-pol2qm74	5857	1	The	the	DT
cord-015021-pol2qm74	5857	2	postoperative	postoperative	JJ
cord-015021-pol2qm74	5857	3	changes	change	NNS
cord-015021-pol2qm74	5857	4	after	after	IN
cord-015021-pol2qm74	5857	5	osteosynthesis	osteosynthesis	NN
cord-015021-pol2qm74	5857	6	of	of	IN
cord-015021-pol2qm74	5857	7	the	the	DT
cord-015021-pol2qm74	5857	8	femur	femur	NN
cord-015021-pol2qm74	5857	9	or	or	CC
cord-015021-pol2qm74	5857	10	pelvis	pelvi	NNS
cord-015021-pol2qm74	5857	11	were	be	VBD
cord-015021-pol2qm74	5857	12	comparable	comparable	JJ
cord-015021-pol2qm74	5857	13	to	to	IN
cord-015021-pol2qm74	5857	14	the	the	DT
cord-015021-pol2qm74	5857	15	alterations	alteration	NNS
cord-015021-pol2qm74	5857	16	noticed	notice	VBN
cord-015021-pol2qm74	5857	17	after	after	IN
cord-015021-pol2qm74	5857	18	smaller	small	JJR
cord-015021-pol2qm74	5857	19	(	(	-LRB-
cord-015021-pol2qm74	5857	20	ISS	ISS	NNP
cord-015021-pol2qm74	5857	21	1	1	CD
cord-015021-pol2qm74	5857	22	to	to	IN
cord-015021-pol2qm74	5857	23	24	24	CD
cord-015021-pol2qm74	5857	24	)	)	-RRB-
cord-015021-pol2qm74	5857	25	or	or	CC
cord-015021-pol2qm74	5857	26	moderate	moderate	JJ
cord-015021-pol2qm74	5857	27	(	(	-LRB-
cord-015021-pol2qm74	5857	28	ISS	ISS	NNP
cord-015021-pol2qm74	5857	29	25	25	CD
cord-015021-pol2qm74	5857	30	to	to	IN
cord-015021-pol2qm74	5857	31	40	40	CD
cord-015021-pol2qm74	5857	32	)	)	-RRB-
cord-015021-pol2qm74	5857	33	accidental	accidental	JJ
cord-015021-pol2qm74	5857	34	trauma	trauma	NN
cord-015021-pol2qm74	5857	35	for	for	IN
cord-015021-pol2qm74	5857	36	neutrophil	neutrophil	NN
cord-015021-pol2qm74	5857	37	elastuse	elastuse	NN
cord-015021-pol2qm74	5857	38	,	,	,
cord-015021-pol2qm74	5857	39	heart	heart	NN
cord-015021-pol2qm74	5857	40	rate	rate	NN
cord-015021-pol2qm74	5857	41	,	,	,
cord-015021-pol2qm74	5857	42	pO2	pO2	NNP
cord-015021-pol2qm74	5857	43	/	/	SYM
cord-015021-pol2qm74	5857	44	FiO2-ratio	FiO2-ratio	NNP
cord-015021-pol2qm74	5857	45	and	and	CC
cord-015021-pol2qm74	5857	46	parameters	parameter	NNS
cord-015021-pol2qm74	5857	47	of	of	IN
cord-015021-pol2qm74	5857	48	the	the	DT
cord-015021-pol2qm74	5857	49	coagulation	coagulation	NN
cord-015021-pol2qm74	5857	50	system	system	NN
cord-015021-pol2qm74	5857	51	.	.	.
cord-015021-pol2qm74	5858	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	5858	2	:	:	:
cord-015021-pol2qm74	5859	1	There	there	EX
cord-015021-pol2qm74	5859	2	is	be	VBZ
cord-015021-pol2qm74	5859	3	a	a	DT
cord-015021-pol2qm74	5859	4	considerable	considerable	JJ
cord-015021-pol2qm74	5859	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5859	6	response	response	NN
cord-015021-pol2qm74	5859	7	to	to	IN
cord-015021-pol2qm74	5859	8	operative	operative	JJ
cord-015021-pol2qm74	5859	9	procedures	procedure	NNS
cord-015021-pol2qm74	5859	10	that	that	WDT
cord-015021-pol2qm74	5859	11	varies	vary	VBZ
cord-015021-pol2qm74	5859	12	with	with	IN
cord-015021-pol2qm74	5859	13	the	the	DT
cord-015021-pol2qm74	5859	14	type	type	NN
cord-015021-pol2qm74	5859	15	of	of	IN
cord-015021-pol2qm74	5859	16	surgery	surgery	NN
cord-015021-pol2qm74	5859	17	.	.	.
cord-015021-pol2qm74	5860	1	Large	large	JJ
cord-015021-pol2qm74	5860	2	operations	operation	NNS
cord-015021-pol2qm74	5860	3	cause	cause	VBP
cord-015021-pol2qm74	5860	4	changes	change	NNS
cord-015021-pol2qm74	5860	5	in	in	IN
cord-015021-pol2qm74	5860	6	the	the	DT
cord-015021-pol2qm74	5860	7	body	body	NN
cord-015021-pol2qm74	5860	8	homeostasis	homeostasis	NN
cord-015021-pol2qm74	5860	9	that	that	WDT
cord-015021-pol2qm74	5860	10	resemble	resemble	VBP
cord-015021-pol2qm74	5860	11	those	those	DT
cord-015021-pol2qm74	5860	12	after	after	IN
cord-015021-pol2qm74	5860	13	multiple	multiple	JJ
cord-015021-pol2qm74	5860	14	injuries	injury	NNS
cord-015021-pol2qm74	5860	15	.	.	.
cord-015021-pol2qm74	5861	1	It	-PRON-	PRP
cord-015021-pol2qm74	5861	2	remains	remain	VBZ
cord-015021-pol2qm74	5861	3	to	to	TO
cord-015021-pol2qm74	5861	4	be	be	VB
cord-015021-pol2qm74	5861	5	established	establish	VBN
cord-015021-pol2qm74	5861	6	whether	whether	IN
cord-015021-pol2qm74	5861	7	the	the	DT
cord-015021-pol2qm74	5861	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	5861	9	sequelae	sequela	NNS
cord-015021-pol2qm74	5861	10	of	of	IN
cord-015021-pol2qm74	5861	11	surgical	surgical	JJ
cord-015021-pol2qm74	5861	12	trauma	trauma	NN
cord-015021-pol2qm74	5861	13	are	be	VBP
cord-015021-pol2qm74	5861	14	additive	additive	NN
cord-015021-pol2qm74	5861	15	to	to	IN
cord-015021-pol2qm74	5861	16	the	the	DT
cord-015021-pol2qm74	5861	17	changes	change	NNS
cord-015021-pol2qm74	5861	18	caused	cause	VBN
cord-015021-pol2qm74	5861	19	by	by	IN
cord-015021-pol2qm74	5861	20	accidental	accidental	JJ
cord-015021-pol2qm74	5861	21	trauma	trauma	NN
cord-015021-pol2qm74	5861	22	.	.	.
cord-015021-pol2qm74	5862	1	Objective	objective	NN
cord-015021-pol2qm74	5862	2	of	of	IN
cord-015021-pol2qm74	5862	3	the	the	DT
cord-015021-pol2qm74	5862	4	study	study	NN
cord-015021-pol2qm74	5862	5	:	:	:
cord-015021-pol2qm74	5862	6	We	-PRON-	PRP
cord-015021-pol2qm74	5862	7	retrospectively	retrospectively	RB
cord-015021-pol2qm74	5862	8	compared	compare	VBD
cord-015021-pol2qm74	5862	9	characteristics	characteristic	NNS
cord-015021-pol2qm74	5862	10	of	of	IN
cord-015021-pol2qm74	5862	11	elderly	elderly	JJ
cord-015021-pol2qm74	5862	12	patients	patient	NNS
cord-015021-pol2qm74	5862	13	(	(	-LRB-
cord-015021-pol2qm74	5862	14	~65	~65	CD
cord-015021-pol2qm74	5862	15	years	year	NNS
cord-015021-pol2qm74	5862	16	)	)	-RRB-
cord-015021-pol2qm74	5862	17	and	and	CC
cord-015021-pol2qm74	5862	18	yeunger	yeunger	NNP
cord-015021-pol2qm74	5862	19	patients	patient	NNS
cord-015021-pol2qm74	5862	20	admitted	admit	VBD
cord-015021-pol2qm74	5862	21	to	to	IN
cord-015021-pol2qm74	5862	22	a	a	DT
cord-015021-pol2qm74	5862	23	surgical	surgical	JJ
cord-015021-pol2qm74	5862	24	{	{	-LRB-
cord-015021-pol2qm74	5862	25	SICU	SICU	NNP
cord-015021-pol2qm74	5862	26	)	)	-RRB-
cord-015021-pol2qm74	5862	27	and	and	CC
cord-015021-pol2qm74	5862	28	a	a	DT
cord-015021-pol2qm74	5862	29	medical	medical	JJ
cord-015021-pol2qm74	5862	30	intensive	intensive	JJ
cord-015021-pol2qm74	5862	31	care	care	NN
cord-015021-pol2qm74	5862	32	unit	unit	NN
cord-015021-pol2qm74	5862	33	(	(	-LRB-
cord-015021-pol2qm74	5862	34	MICU	MICU	NNP
cord-015021-pol2qm74	5862	35	)	)	-RRB-
cord-015021-pol2qm74	5862	36	.	.	.
cord-015021-pol2qm74	5863	1	We	-PRON-	PRP
cord-015021-pol2qm74	5863	2	further	further	RB
cord-015021-pol2qm74	5863	3	studied	study	VBD
cord-015021-pol2qm74	5863	4	the	the	DT
cord-015021-pol2qm74	5863	5	relations	relation	NNS
cord-015021-pol2qm74	5863	6	between	between	IN
cord-015021-pol2qm74	5863	7	advancing	advance	VBG
cord-015021-pol2qm74	5863	8	age	age	NN
cord-015021-pol2qm74	5863	9	,	,	,
cord-015021-pol2qm74	5863	10	chronic	chronic	JJ
cord-015021-pol2qm74	5863	11	disease	disease	NN
cord-015021-pol2qm74	5863	12	,	,	,
cord-015021-pol2qm74	5863	13	sepsis	sepsis	NN
cord-015021-pol2qm74	5863	14	,	,	,
cord-015021-pol2qm74	5863	15	organ	organ	NN
cord-015021-pol2qm74	5863	16	system	system	NN
cord-015021-pol2qm74	5863	17	failure	failure	NN
cord-015021-pol2qm74	5863	18	(	(	-LRB-
cord-015021-pol2qm74	5863	19	OSF	OSF	NNP
cord-015021-pol2qm74	5863	20	)	)	-RRB-
cord-015021-pol2qm74	5863	21	and	and	CC
cord-015021-pol2qm74	5863	22	mortality	mortality	NN
cord-015021-pol2qm74	5863	23	in	in	IN
cord-015021-pol2qm74	5863	24	the	the	DT
cord-015021-pol2qm74	5863	25	elderly	elderly	JJ
cord-015021-pol2qm74	5863	26	group	group	NN
cord-015021-pol2qm74	5863	27	.	.	.
cord-015021-pol2qm74	5864	1	Material	material	NN
cord-015021-pol2qm74	5864	2	and	and	CC
cord-015021-pol2qm74	5864	3	methods	method	NNS
cord-015021-pol2qm74	5864	4	:	:	:
cord-015021-pol2qm74	5864	5	During	during	IN
cord-015021-pol2qm74	5864	6	a	a	DT
cord-015021-pol2qm74	5864	7	1-year	1-year	CD
cord-015021-pol2qm74	5864	8	period	period	NN
cord-015021-pol2qm74	5864	9	,	,	,
cord-015021-pol2qm74	5864	10	538	538	CD
cord-015021-pol2qm74	5864	11	patients	patient	NNS
cord-015021-pol2qm74	5864	12	were	be	VBD
cord-015021-pol2qm74	5864	13	consecutively	consecutively	RB
cord-015021-pol2qm74	5864	14	admitted	admit	VBN
cord-015021-pol2qm74	5864	15	into	into	IN
cord-015021-pol2qm74	5864	16	the	the	DT
cord-015021-pol2qm74	5864	17	8ICU	8icu	NN
cord-015021-pol2qm74	5864	18	;	;	:
cord-015021-pol2qm74	5864	19	and	and	CC
cord-015021-pol2qm74	5864	20	during	during	IN
cord-015021-pol2qm74	5864	21	a	a	DT
cord-015021-pol2qm74	5864	22	2-year	2-year	CD
cord-015021-pol2qm74	5864	23	period	period	NN
cord-015021-pol2qm74	5864	24	,	,	,
cord-015021-pol2qm74	5864	25	487	487	CD
cord-015021-pol2qm74	5864	26	patients	patient	NNS
cord-015021-pol2qm74	5864	27	were	be	VBD
cord-015021-pol2qm74	5864	28	consecutively	consecutively	RB
cord-015021-pol2qm74	5864	29	admitted	admit	VBN
cord-015021-pol2qm74	5864	30	to	to	IN
cord-015021-pol2qm74	5864	31	t	t	NN
cord-015021-pol2qm74	5864	32	~	~	CD
cord-015021-pol2qm74	5864	33	MICH	MICH	NNP
cord-015021-pol2qm74	5864	34	.	.	.
cord-015021-pol2qm74	5865	1	Criteria	criterion	NNS
cord-015021-pol2qm74	5865	2	for	for	IN
cord-015021-pol2qm74	5865	3	chronic	chronic	JJ
cord-015021-pol2qm74	5865	4	disease	disease	NN
cord-015021-pol2qm74	5865	5	,	,	,
cord-015021-pol2qm74	5865	6	sepsis	sepsis	NN
cord-015021-pol2qm74	5865	7	,	,	,
cord-015021-pol2qm74	5865	8	OSFsi.e	osfsi.e	CD
cord-015021-pol2qm74	5865	9	.	.	.
cord-015021-pol2qm74	5866	1	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	5866	2	(	(	-LRB-
cord-015021-pol2qm74	5866	3	CF	CF	NNP
cord-015021-pol2qm74	5866	4	)	)	-RRB-
cord-015021-pol2qm74	5866	5	,	,	,
cord-015021-pol2qm74	5866	6	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	5866	7	(	(	-LRB-
cord-015021-pol2qm74	5866	8	PF	PF	NNP
cord-015021-pol2qm74	5866	9	)	)	-RRB-
cord-015021-pol2qm74	5866	10	,	,	,
cord-015021-pol2qm74	5866	11	renal	renal	JJ
cord-015021-pol2qm74	5866	12	(	(	-LRB-
cord-015021-pol2qm74	5866	13	RF	RF	NNP
cord-015021-pol2qm74	5866	14	)	)	-RRB-
cord-015021-pol2qm74	5866	15	,	,	,
cord-015021-pol2qm74	5866	16	neurological	neurological	JJ
cord-015021-pol2qm74	5866	17	(	(	-LRB-
cord-015021-pol2qm74	5866	18	NF	NF	NNP
cord-015021-pol2qm74	5866	19	)	)	-RRB-
cord-015021-pol2qm74	5866	20	,	,	,
cord-015021-pol2qm74	5866	21	haematological	haematological	FW
cord-015021-pol2qm74	5866	22	(	(	-LRB-
cord-015021-pol2qm74	5866	23	HF	HF	NNP
cord-015021-pol2qm74	5866	24	)	)	-RRB-
cord-015021-pol2qm74	5866	25	,	,	,
cord-015021-pol2qm74	5866	26	hepatic	hepatic	JJ
cord-015021-pol2qm74	5866	27	(	(	-LRB-
cord-015021-pol2qm74	5866	28	LF	LF	NNP
cord-015021-pol2qm74	5866	29	)	)	-RRB-
cord-015021-pol2qm74	5866	30	,	,	,
cord-015021-pol2qm74	5866	31	and	and	CC
cord-015021-pol2qm74	5866	32	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	5866	33	failure	failure	NN
cord-015021-pol2qm74	5866	34	(	(	-LRB-
cord-015021-pol2qm74	5866	35	GF)-were	gf)-were	CD
cord-015021-pol2qm74	5866	36	derived	derive	VBN
cord-015021-pol2qm74	5866	37	from	from	IN
cord-015021-pol2qm74	5866	38	the	the	DT
cord-015021-pol2qm74	5866	39	literature	literature	NN
cord-015021-pol2qm74	5866	40	.	.	.
cord-015021-pol2qm74	5867	1	Results	result	NNS
cord-015021-pol2qm74	5867	2	:	:	:
cord-015021-pol2qm74	5868	1	Patients	patient	NNS
cord-015021-pol2qm74	5868	2	from	from	IN
cord-015021-pol2qm74	5868	3	the	the	DT
cord-015021-pol2qm74	5868	4	SICU	SICU	NNP
cord-015021-pol2qm74	5868	5	and	and	CC
cord-015021-pol2qm74	5868	6	~	~	NFP
cord-015021-pol2qm74	5868	7	CU	CU	NNP
cord-015021-pol2qm74	5868	8	were	be	VBD
cord-015021-pol2qm74	5868	9	similar	similar	JJ
cord-015021-pol2qm74	5868	10	in	in	IN
cord-015021-pol2qm74	5868	11	age	age	NN
cord-015021-pol2qm74	5868	12	,	,	,
cord-015021-pol2qm74	5868	13	number	number	NN
cord-015021-pol2qm74	5868	14	of	of	IN
cord-015021-pol2qm74	5868	15	OSF	OSF	NNP
cord-015021-pol2qm74	5868	16	,	,	,
cord-015021-pol2qm74	5868	17	and	and	CC
cord-015021-pol2qm74	5868	18	length	length	NN
cord-015021-pol2qm74	5868	19	of	of	IN
cord-015021-pol2qm74	5868	20	stay	stay	NN
cord-015021-pol2qm74	5868	21	.	.	.
cord-015021-pol2qm74	5869	1	However	however	RB
cord-015021-pol2qm74	5869	2	,	,	,
cord-015021-pol2qm74	5869	3	when	when	WRB
cord-015021-pol2qm74	5869	4	compared	compare	VBN
cord-015021-pol2qm74	5869	5	to	to	IN
cord-015021-pol2qm74	5869	6	SICU	SICU	NNP
cord-015021-pol2qm74	5869	7	patients	patient	NNS
cord-015021-pol2qm74	5869	8	,	,	,
cord-015021-pol2qm74	5869	9	MICU	MICU	NNP
cord-015021-pol2qm74	5869	10	patients	patient	NNS
cord-015021-pol2qm74	5869	11	had	have	VBD
cord-015021-pol2qm74	5869	12	more	more	JJR
cord-015021-pol2qm74	5869	13	CF	cf	NN
cord-015021-pol2qm74	5869	14	(	(	-LRB-
cord-015021-pol2qm74	5869	15	p	p	NN
cord-015021-pol2qm74	5869	16	<	<	XX
cord-015021-pol2qm74	5869	17	O.O1	O.O1	NNP
cord-015021-pol2qm74	5869	18	)	)	-RRB-
cord-015021-pol2qm74	5869	19	,	,	,
cord-015021-pol2qm74	5869	20	sepsis	sepsis	NN
cord-015021-pol2qm74	5869	21	(	(	-LRB-
cord-015021-pol2qm74	5869	22	p	p	NN
cord-015021-pol2qm74	5869	23	<	<	XX
cord-015021-pol2qm74	5869	24	O.O01	O.O01	NNP
cord-015021-pol2qm74	5869	25	)	)	-RRB-
cord-015021-pol2qm74	5869	26	,	,	,
cord-015021-pol2qm74	5869	27	and	and	CC
cord-015021-pol2qm74	5869	28	mortality	mortality	NN
cord-015021-pol2qm74	5869	29	rate	rate	NN
cord-015021-pol2qm74	5869	30	(	(	-LRB-
cord-015021-pol2qm74	5869	31	27	27	CD
cord-015021-pol2qm74	5869	32	%	%	NN
cord-015021-pol2qm74	5869	33	vs.	vs.	IN
cord-015021-pol2qm74	5869	34	ii~	ii~	NNP
cord-015021-pol2qm74	5869	35	,	,	,
cord-015021-pol2qm74	5869	36	p	p	NN
cord-015021-pol2qm74	5869	37	<	<	XX
cord-015021-pol2qm74	5869	38	O.OOl	o.ool	XX
cord-015021-pol2qm74	5869	39	)	)	-RRB-
cord-015021-pol2qm74	5869	40	.	.	.
cord-015021-pol2qm74	5870	1	In	in	IN
cord-015021-pol2qm74	5870	2	contrast	contrast	NN
cord-015021-pol2qm74	5870	3	,	,	,
cord-015021-pol2qm74	5870	4	SICU	SICU	NNP
cord-015021-pol2qm74	5870	5	patients	patient	NNS
cord-015021-pol2qm74	5870	6	had	have	VBD
cord-015021-pol2qm74	5870	7	more	more	JJR
cord-015021-pol2qm74	5870	8	HP	HP	NNP
cord-015021-pol2qm74	5870	9	and	and	CC
cord-015021-pol2qm74	5870	10	NF	nf	NN
cord-015021-pol2qm74	5870	11	,	,	,
cord-015021-pol2qm74	5870	12	and	and	CC
cord-015021-pol2qm74	5870	13	prior	prior	JJ
cord-015021-pol2qm74	5870	14	chronic	chronic	JJ
cord-015021-pol2qm74	5870	15	disease	disease	NN
cord-015021-pol2qm74	5870	16	(	(	-LRB-
cord-015021-pol2qm74	5870	17	all	all	DT
cord-015021-pol2qm74	5870	18	,	,	,
cord-015021-pol2qm74	5870	19	p	p	NN
cord-015021-pol2qm74	5870	20	<	<	XX
cord-015021-pol2qm74	5870	21	O.O01	o.o01	NN
cord-015021-pol2qm74	5870	22	)	)	-RRB-
cord-015021-pol2qm74	5870	23	.	.	.
cord-015021-pol2qm74	5871	1	Of	of	IN
cord-015021-pol2qm74	5871	2	the	the	DT
cord-015021-pol2qm74	5871	3	total	total	JJ
cord-015021-pol2qm74	5871	4	group	group	NN
cord-015021-pol2qm74	5871	5	of	of	IN
cord-015021-pol2qm74	5871	6	1,025	1,025	CD
cord-015021-pol2qm74	5871	7	patients	patient	NNS
cord-015021-pol2qm74	5871	8	,	,	,
cord-015021-pol2qm74	5871	9	there	there	EX
cord-015021-pol2qm74	5871	10	were	be	VBD
cord-015021-pol2qm74	5871	11	406	406	CD
cord-015021-pol2qm74	5871	12	(	(	-LRB-
cord-015021-pol2qm74	5871	13	40	40	CD
cord-015021-pol2qm74	5871	14	%	%	NN
cord-015021-pol2qm74	5871	15	)	)	-RRB-
cord-015021-pol2qm74	5871	16	patients	patient	NNS
cord-015021-pol2qm74	5871	17	65	65	CD
cord-015021-pol2qm74	5871	18	years	year	NNS
cord-015021-pol2qm74	5871	19	of	of	IN
cord-015021-pol2qm74	5871	20	age	age	NN
cord-015021-pol2qm74	5871	21	or	or	CC
cord-015021-pol2qm74	5871	22	older	old	JJR
cord-015021-pol2qm74	5871	23	.	.	.
cord-015021-pol2qm74	5872	1	Elderly	elderly	JJ
cord-015021-pol2qm74	5872	2	and	and	CC
cord-015021-pol2qm74	5872	3	younger	young	JJR
cord-015021-pol2qm74	5872	4	patients	patient	NNS
cord-015021-pol2qm74	5872	5	had	have	VBD
cord-015021-pol2qm74	5872	6	comparable	comparable	JJ
cord-015021-pol2qm74	5872	7	length	length	NN
cord-015021-pol2qm74	5872	8	of	of	IN
cord-015021-pol2qm74	5872	9	stay	stay	NN
cord-015021-pol2qm74	5872	10	in	in	IN
cord-015021-pol2qm74	5872	11	the	the	DT
cord-015021-pol2qm74	5872	12	ICJ	ICJ	NNP
cord-015021-pol2qm74	5872	13	,	,	,
cord-015021-pol2qm74	5872	14	but	but	CC
cord-015021-pol2qm74	5872	15	elderly	elderly	JJ
cord-015021-pol2qm74	5872	16	patients	patient	NNS
cord-015021-pol2qm74	5872	17	had	have	VBD
cord-015021-pol2qm74	5872	18	significantly	significantly	RB
cord-015021-pol2qm74	5872	19	more	more	RBR
cord-015021-pol2qm74	5872	20	chronic	chronic	JJ
cord-015021-pol2qm74	5872	21	disease	disease	NN
cord-015021-pol2qm74	5872	22	,	,	,
cord-015021-pol2qm74	5872	23	sepsis	sepsis	NN
cord-015021-pol2qm74	5872	24	,	,	,
cord-015021-pol2qm74	5872	25	and	and	CC
cord-015021-pol2qm74	5872	26	number	number	NN
cord-015021-pol2qm74	5872	27	of	of	IN
cord-015021-pol2qm74	5872	28	OSF	OSF	NNP
cord-015021-pol2qm74	5872	29	(	(	-LRB-
cord-015021-pol2qm74	5872	30	all	all	DT
cord-015021-pol2qm74	5872	31	,	,	,
cord-015021-pol2qm74	5872	32	p	p	NN
cord-015021-pol2qm74	5872	33	<	<	XX
cord-015021-pol2qm74	5872	34	O.O02	O.O02	NNP
cord-015021-pol2qm74	5872	35	)	)	-RRB-
cord-015021-pol2qm74	5872	36	.	.	.
cord-015021-pol2qm74	5873	1	All	all	DT
cord-015021-pol2qm74	5873	2	OSFs	osf	NNS
cord-015021-pol2qm74	5873	3	,	,	,
cord-015021-pol2qm74	5873	4	except	except	IN
cord-015021-pol2qm74	5873	5	HF	HF	NNP
cord-015021-pol2qm74	5873	6	and	and	CC
cord-015021-pol2qm74	5873	7	NF	NF	NNP
cord-015021-pol2qm74	5873	8	,	,	,
cord-015021-pol2qm74	5873	9	were	be	VBD
cord-015021-pol2qm74	5873	10	more	more	JJR
cord-015021-pol2qm74	5874	1	~o~	~o~	.
cord-015021-pol2qm74	5875	1	mon	mon	NNP
cord-015021-pol2qm74	5875	2	i~	i~	NNP
cord-015021-pol2qm74	5875	3	mdeLjl	mdeLjl	NNP
cord-015021-pol2qm74	5875	4	,	,	,
cord-015021-pol2qm74	5875	5	eompard	eompard	NN
cord-015021-pol2qm74	5875	6	to	to	IN
cord-015021-pol2qm74	5875	7	you	-PRON-	PRP
cord-015021-pol2qm74	5875	8	-	-	HYPH
cord-015021-pol2qm74	5875	9	ger	ger	JJ
cord-015021-pol2qm74	5875	10	patients	patient	NNS
cord-015021-pol2qm74	5875	11	.	.	.
cord-015021-pol2qm74	5876	1	~he	~he	JJ
cord-015021-pol2qm74	5876	2	mortality	mortality	NN
cord-015021-pol2qm74	5876	3	is	be	VBZ
cord-015021-pol2qm74	5876	4	also	also	RB
cord-015021-pol2qm74	5876	5	higher	high	JJR
cord-015021-pol2qm74	5876	6	in	in	IN
cord-015021-pol2qm74	5876	7	elderly	elderly	JJ
cord-015021-pol2qm74	5876	8	patients	patient	NNS
cord-015021-pol2qm74	5876	9	(	(	-LRB-
cord-015021-pol2qm74	5876	10	29	29	CD
cord-015021-pol2qm74	5876	11	%	%	NN
cord-015021-pol2qm74	5876	12	vs.	vs.	IN
cord-015021-pol2qm74	5876	13	11	11	CD
cord-015021-pol2qm74	5876	14	%	%	NN
cord-015021-pol2qm74	5876	15	in	in	IN
cord-015021-pol2qm74	5876	16	younger	young	JJR
cord-015021-pol2qm74	5876	17	patients	patient	NNS
cord-015021-pol2qm74	5876	18	)	)	-RRB-
cord-015021-pol2qm74	5876	19	.	.	.
cord-015021-pol2qm74	5877	1	After	after	IN
cord-015021-pol2qm74	5877	2	multiple	multiple	JJ
cord-015021-pol2qm74	5877	3	logistic	logistic	JJ
cord-015021-pol2qm74	5877	4	regression	regression	NN
cord-015021-pol2qm74	5877	5	,	,	,
cord-015021-pol2qm74	5877	6	only	only	JJ
cord-015021-pol2qm74	5877	7	number	number	NN
cord-015021-pol2qm74	5877	8	of	of	IN
cord-015021-pol2qm74	5877	9	OSF	OSF	NNP
cord-015021-pol2qm74	5877	10	increased	increase	VBN
cord-015021-pol2qm74	5877	11	mortality	mortality	NN
cord-015021-pol2qm74	5877	12	by	by	IN
cord-015021-pol2qm74	5877	13	a	a	DT
cord-015021-pol2qm74	5877	14	factor	factor	NN
cord-015021-pol2qm74	5877	15	of	of	IN
cord-015021-pol2qm74	5877	16	2.48	2.48	CD
cord-015021-pol2qm74	5877	17	(	(	-LRB-
cord-015021-pol2qm74	5877	18	95	95	CD
cord-015021-pol2qm74	5877	19	%	%	NN
cord-015021-pol2qm74	5877	20	confidence	confidence	NN
cord-015021-pol2qm74	5877	21	limits	limit	NNS
cord-015021-pol2qm74	5877	22	,	,	,
cord-015021-pol2qm74	5877	23	1.97	1.97	CD
cord-015021-pol2qm74	5877	24	-	-	SYM
cord-015021-pol2qm74	5877	25	3.12	3.12	CD
cord-015021-pol2qm74	5877	26	)	)	-RRB-
cord-015021-pol2qm74	5877	27	,	,	,
cord-015021-pol2qm74	5877	28	age	age	NN
cord-015021-pol2qm74	5877	29	did	do	VBD
cord-015021-pol2qm74	5877	30	not	not	RB
cord-015021-pol2qm74	5877	31	increased	increase	VBN
cord-015021-pol2qm74	5877	32	[	[	-LRB-
cord-015021-pol2qm74	5877	33	odds	odd	NNS
cord-015021-pol2qm74	5877	34	ratio	ratio	NN
cord-015021-pol2qm74	5877	35	1.05	1.05	CD
cord-015021-pol2qm74	5877	36	(	(	-LRB-
cord-015021-pol2qm74	5877	37	i.01i.i0	i.01i.i0	NN
cord-015021-pol2qm74	5877	38	)	)	-RRB-
cord-015021-pol2qm74	5877	39	]	]	-RRB-
cord-015021-pol2qm74	5877	40	,	,	,
cord-015021-pol2qm74	5877	41	while	while	IN
cord-015021-pol2qm74	5877	42	admission	admission	NN
cord-015021-pol2qm74	5877	43	to	to	IN
cord-015021-pol2qm74	5877	44	the	the	DT
cord-015021-pol2qm74	5877	45	SICU	SICU	NNP
cord-015021-pol2qm74	5877	46	reduced	reduce	VBN
cord-015021-pol2qm74	5877	47	risk	risk	NN
cord-015021-pol2qm74	5877	48	of	of	IN
cord-015021-pol2qm74	5877	49	death	death	NN
cord-015021-pol2qm74	5877	50	by	by	IN
cord-015021-pol2qm74	5877	51	a	a	DT
cord-015021-pol2qm74	5877	52	factor	factor	NN
cord-015021-pol2qm74	5877	53	of	of	IN
cord-015021-pol2qm74	5877	54	0.15	0.15	CD
cord-015021-pol2qm74	5877	55	(	(	-LRB-
cord-015021-pol2qm74	5877	56	0.08	0.08	CD
cord-015021-pol2qm74	5877	57	-	-	SYM
cord-015021-pol2qm74	5877	58	0.30	0.30	CD
cord-015021-pol2qm74	5877	59	)	)	-RRB-
cord-015021-pol2qm74	5877	60	.	.	.
cord-015021-pol2qm74	5878	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	5878	2	:	:	:
cord-015021-pol2qm74	5879	1	Based	base	VBN
cord-015021-pol2qm74	5879	2	on	on	IN
cord-015021-pol2qm74	5879	3	these	these	DT
cord-015021-pol2qm74	5879	4	results	result	NNS
cord-015021-pol2qm74	5879	5	,	,	,
cord-015021-pol2qm74	5879	6	we	-PRON-	PRP
cord-015021-pol2qm74	5879	7	conclude	conclude	VBP
cord-015021-pol2qm74	5879	8	that	that	IN
cord-015021-pol2qm74	5879	9	age	age	NN
cord-015021-pol2qm74	5879	10	does	do	VBZ
cord-015021-pol2qm74	5879	11	not	not	RB
cord-015021-pol2qm74	5879	12	have	have	VB
cord-015021-pol2qm74	5879	13	any	any	DT
cord-015021-pol2qm74	5879	14	impact	impact	NN
cord-015021-pol2qm74	5879	15	on	on	IN
cord-015021-pol2qm74	5879	16	ICU	ICU	NNP
cord-015021-pol2qm74	5879	17	outcome	outcome	NN
cord-015021-pol2qm74	5879	18	in	in	IN
cord-015021-pol2qm74	5879	19	the	the	DT
cord-015021-pol2qm74	5879	20	elderly	elderly	JJ
cord-015021-pol2qm74	5879	21	.	.	.
cord-015021-pol2qm74	5880	1	The	the	DT
cord-015021-pol2qm74	5880	2	only	only	JJ
cord-015021-pol2qm74	5880	3	prognostic	prognostic	JJ
cord-015021-pol2qm74	5880	4	factor	factor	NN
cord-015021-pol2qm74	5880	5	is	be	VBZ
cord-015021-pol2qm74	5880	6	the	the	DT
cord-015021-pol2qm74	5880	7	extent	extent	NN
cord-015021-pol2qm74	5880	8	of	of	IN
cord-015021-pol2qm74	5880	9	acute	acute	JJ
cord-015021-pol2qm74	5880	10	disease	disease	NN
cord-015021-pol2qm74	5880	11	,	,	,
cord-015021-pol2qm74	5880	12	as	as	IN
cord-015021-pol2qm74	5880	13	measured	measure	VBN
cord-015021-pol2qm74	5880	14	by	by	IN
cord-015021-pol2qm74	5880	15	the	the	DT
cord-015021-pol2qm74	5880	16	number	number	NN
cord-015021-pol2qm74	5880	17	of	of	IN
cord-015021-pol2qm74	5880	18	OSF	OSF	NNP
cord-015021-pol2qm74	5880	19	.	.	.
cord-015021-pol2qm74	5881	1	Hence	hence	RB
cord-015021-pol2qm74	5881	2	,	,	,
cord-015021-pol2qm74	5881	3	prevention	prevention	NN
cord-015021-pol2qm74	5881	4	of	of	IN
cord-015021-pol2qm74	5881	5	OaF	oaf	NN
cord-015021-pol2qm74	5881	6	may	may	MD
cord-015021-pol2qm74	5881	7	influence	influence	VB
cord-015021-pol2qm74	5881	8	outcome	outcome	NN
cord-015021-pol2qm74	5881	9	in	in	IN
cord-015021-pol2qm74	5881	10	elderly	elderly	JJ
cord-015021-pol2qm74	5881	11	patients	patient	NNS
cord-015021-pol2qm74	5881	12	with	with	IN
cord-015021-pol2qm74	5881	13	critical	critical	JJ
cord-015021-pol2qm74	5881	14	illness	illness	NN
cord-015021-pol2qm74	5881	15	.	.	.
cord-015021-pol2qm74	5882	1	The	the	DT
cord-015021-pol2qm74	5882	2	lower	low	JJR
cord-015021-pol2qm74	5882	3	risk	risk	NN
cord-015021-pol2qm74	5882	4	of	of	IN
cord-015021-pol2qm74	5882	5	death	death	NN
cord-015021-pol2qm74	5882	6	in	in	IN
cord-015021-pol2qm74	5882	7	SICUpatients	sicupatient	NNS
cord-015021-pol2qm74	5882	8	may	may	MD
cord-015021-pol2qm74	5882	9	be	be	VB
cord-015021-pol2qm74	5882	10	explained	explain	VBN
cord-015021-pol2qm74	5882	11	by	by	IN
cord-015021-pol2qm74	5882	12	the	the	DT
cord-015021-pol2qm74	5882	13	large	large	JJ
cord-015021-pol2qm74	5882	14	proportion	proportion	NN
cord-015021-pol2qm74	5882	15	of	of	IN
cord-015021-pol2qm74	5882	16	postoperative	postoperative	JJ
cord-015021-pol2qm74	5882	17	elective	elective	JJ
cord-015021-pol2qm74	5882	18	patients	patient	NNS
cord-015021-pol2qm74	5882	19	with	with	IN
cord-015021-pol2qm74	5882	20	relative	relative	JJ
cord-015021-pol2qm74	5882	21	mild	mild	JJ
cord-015021-pol2qm74	5882	22	chronic	chronic	JJ
cord-015021-pol2qm74	5882	23	disease	disease	NN
cord-015021-pol2qm74	5882	24	,	,	,
cord-015021-pol2qm74	5882	25	and	and	CC
cord-015021-pol2qm74	5882	26	the	the	DT
cord-015021-pol2qm74	5882	27	lower	low	JJR
cord-015021-pol2qm74	5882	28	incidence	incidence	NN
cord-015021-pol2qm74	5882	29	of	of	IN
cord-015021-pol2qm74	5882	30	sepsis	sepsis	NN
cord-015021-pol2qm74	5882	31	.	.	.
cord-015021-pol2qm74	5883	1	Department	Department	NNP
cord-015021-pol2qm74	5883	2	of	of	IN
cord-015021-pol2qm74	5883	3	Surgery	Surgery	NNP
cord-015021-pol2qm74	5883	4	,	,	,
cord-015021-pol2qm74	5883	5	Free	Free	NNP
cord-015021-pol2qm74	5883	6	University	University	NNP
cord-015021-pol2qm74	5883	7	Hospital	Hospital	NNP
cord-015021-pol2qm74	5883	8	,	,	,
cord-015021-pol2qm74	5883	9	De	De	NNP
cord-015021-pol2qm74	5883	10	Boelelaan	Boelelaan	NNP
cord-015021-pol2qm74	5883	11	1117	1117	CD
cord-015021-pol2qm74	5883	12	,	,	,
cord-015021-pol2qm74	5883	13	1081	1081	CD
cord-015021-pol2qm74	5883	14	~V	~V	.
cord-015021-pol2qm74	5883	15	Amsterdam	Amsterdam	NNP
cord-015021-pol2qm74	5883	16	,	,	,
cord-015021-pol2qm74	5883	17	The	the	DT
cord-015021-pol2qm74	5883	18	Netherlands	Netherlands	NNP
cord-015021-pol2qm74	5883	19	.	.	.
cord-015021-pol2qm74	5884	1	SEPTIC	septic	JJ
cord-015021-pol2qm74	5884	2	SHOCK	shock	NN
cord-015021-pol2qm74	5884	3	AND	and	CC
cord-015021-pol2qm74	5884	4	LOW	low	JJ
cord-015021-pol2qm74	5884	5	OUTPUT	output	NN
cord-015021-pol2qm74	5884	6	SYNDROME	syndrome	NN
cord-015021-pol2qm74	5885	1	H.Miyakawa	H.Miyakawa	NNP
cord-015021-pol2qm74	5885	2	,	,	,
cord-015021-pol2qm74	5885	3	T.Noguchi	T.Noguchi	NNP
cord-015021-pol2qm74	5885	4	,	,	,
cord-015021-pol2qm74	5885	5	S.Hattori	S.Hattori	NNP
cord-015021-pol2qm74	5885	6	,	,	,
cord-015021-pol2qm74	5885	7	A.	a.	NN
cord-015021-pol2qm74	5885	8	Mizutani	Mizutani	NNP
cord-015021-pol2qm74	5885	9	,	,	,
cord-015021-pol2qm74	5885	10	M.	M.	NNP
cord-015021-pol2qm74	5885	11	Mori	Mori	NNP
cord-015021-pol2qm74	5885	12	and	and	CC
cord-015021-pol2qm74	5885	13	N.Honda	N.Honda	NNP
cord-015021-pol2qm74	5885	14	Objectives	Objectives	NNPS
cord-015021-pol2qm74	5885	15	:	:	:
cord-015021-pol2qm74	5885	16	Cytckines	cytckine	NNS
cord-015021-pol2qm74	5885	17	are	be	VBP
cord-015021-pol2qm74	5885	18	thought	think	VBN
cord-015021-pol2qm74	5885	19	to	to	TO
cord-015021-pol2qm74	5885	20	cause	cause	VB
cord-015021-pol2qm74	5885	21	the	the	DT
cord-015021-pol2qm74	5885	22	acute	acute	JJ
cord-015021-pol2qm74	5885	23	phase	phase	NN
cord-015021-pol2qm74	5885	24	reactions	reaction	NNS
cord-015021-pol2qm74	5885	25	under	under	IN
cord-015021-pol2qm74	5885	26	several	several	JJ
cord-015021-pol2qm74	5885	27	critical	critical	JJ
cord-015021-pol2qm74	5885	28	conditions	condition	NNS
cord-015021-pol2qm74	5885	29	.	.	.
cord-015021-pol2qm74	5886	1	We	-PRON-	PRP
cord-015021-pol2qm74	5886	2	had	have	VBD
cord-015021-pol2qm74	5886	3	investigated	investigate	VBN
cord-015021-pol2qm74	5886	4	the	the	DT
cord-015021-pol2qm74	5886	5	relationships	relationship	NNS
cord-015021-pol2qm74	5886	6	between	between	IN
cord-015021-pol2qm74	5886	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	5886	8	network	network	NN
cord-015021-pol2qm74	5886	9	which	which	WDT
cord-015021-pol2qm74	5886	10	included	include	VBD
cord-015021-pol2qm74	5886	11	IL-6,1L-8,ACTH	IL-6,1L-8,ACTH	NNP
cord-015021-pol2qm74	5886	12	and	and	CC
cord-015021-pol2qm74	5886	13	cortisol	cortisol	NN
cord-015021-pol2qm74	5886	14	,	,	,
cord-015021-pol2qm74	5886	15	and	and	CC
cord-015021-pol2qm74	5886	16	the	the	DT
cord-015021-pol2qm74	5886	17	outcome	outcome	NN
cord-015021-pol2qm74	5886	18	of	of	IN
cord-015021-pol2qm74	5886	19	the	the	DT
cord-015021-pol2qm74	5886	20	patients	patient	NNS
cord-015021-pol2qm74	5886	21	with	with	IN
cord-015021-pol2qm74	5886	22	septic	septic	JJ
cord-015021-pol2qm74	5886	23	shock	shock	NN
cord-015021-pol2qm74	5886	24	or	or	CC
cord-015021-pol2qm74	5886	25	low	low	JJ
cord-015021-pol2qm74	5886	26	output	output	NN
cord-015021-pol2qm74	5886	27	syndrome	syndrome	NN
cord-015021-pol2qm74	5886	28	(	(	-LRB-
cord-015021-pol2qm74	5886	29	LOS	LOS	NNP
cord-015021-pol2qm74	5886	30	)	)	-RRB-
cord-015021-pol2qm74	5886	31	.	.	.
cord-015021-pol2qm74	5887	1	Materials	material	NNS
cord-015021-pol2qm74	5887	2	and	and	CC
cord-015021-pol2qm74	5887	3	methods	method	NNS
cord-015021-pol2qm74	5887	4	:	:	:
cord-015021-pol2qm74	5887	5	In	in	IN
cord-015021-pol2qm74	5887	6	the	the	DT
cord-015021-pol2qm74	5887	7	septic	septic	JJ
cord-015021-pol2qm74	5887	8	group	group	NN
cord-015021-pol2qm74	5887	9	and	and	CC
cord-015021-pol2qm74	5887	10	LOS	LOS	NNP
cord-015021-pol2qm74	5887	11	group	group	NN
cord-015021-pol2qm74	5887	12	,	,	,
cord-015021-pol2qm74	5887	13	nine	nine	CD
cord-015021-pol2qm74	5887	14	and	and	CC
cord-015021-pol2qm74	5887	15	four	four	CD
cord-015021-pol2qm74	5887	16	patients	patient	NNS
cord-015021-pol2qm74	5887	17	were	be	VBD
cord-015021-pol2qm74	5887	18	enrolled	enrol	VBN
cord-015021-pol2qm74	5887	19	respectively	respectively	RB
cord-015021-pol2qm74	5887	20	.	.	.
cord-015021-pol2qm74	5888	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	5888	2	,	,	,
cord-015021-pol2qm74	5888	3	the	the	DT
cord-015021-pol2qm74	5888	4	patients	patient	NNS
cord-015021-pol2qm74	5888	5	in	in	IN
cord-015021-pol2qm74	5888	6	the	the	DT
cord-015021-pol2qm74	5888	7	septic	septic	JJ
cord-015021-pol2qm74	5888	8	group	group	NN
cord-015021-pol2qm74	5888	9	were	be	VBD
cord-015021-pol2qm74	5888	10	divided	divide	VBN
cord-015021-pol2qm74	5888	11	into	into	IN
cord-015021-pol2qm74	5888	12	two	two	CD
cord-015021-pol2qm74	5888	13	groups	group	NNS
cord-015021-pol2qm74	5888	14	,	,	,
cord-015021-pol2qm74	5888	15	survival	survival	NN
cord-015021-pol2qm74	5888	16	(	(	-LRB-
cord-015021-pol2qm74	5888	17	n=5	n=5	NNP
cord-015021-pol2qm74	5888	18	)	)	-RRB-
cord-015021-pol2qm74	5888	19	and	and	CC
cord-015021-pol2qm74	5888	20	non	non	JJ
cord-015021-pol2qm74	5888	21	-	-	JJ
cord-015021-pol2qm74	5888	22	survival	survival	JJ
cord-015021-pol2qm74	5888	23	group	group	NN
cord-015021-pol2qm74	5889	1	(	(	-LRB-
cord-015021-pol2qm74	5889	2	n=4).tn	n=4).tn	ADD
cord-015021-pol2qm74	5890	1	these	these	DT
cord-015021-pol2qm74	5890	2	patients	patient	NNS
cord-015021-pol2qm74	5890	3	,	,	,
cord-015021-pol2qm74	5890	4	lL-6,1L-8,ACTH	lL-6,1L-8,ACTH	NNP
cord-015021-pol2qm74	5890	5	and	and	CC
cord-015021-pol2qm74	5890	6	cortisol	cortisol	NN
cord-015021-pol2qm74	5890	7	had	have	VBD
cord-015021-pol2qm74	5890	8	been	be	VBN
cord-015021-pol2qm74	5890	9	measured	measure	VBN
cord-015021-pol2qm74	5890	10	every	every	DT
cord-015021-pol2qm74	5890	11	day	day	NN
cord-015021-pol2qm74	5890	12	after	after	IN
cord-015021-pol2qm74	5890	13	diagnosis	diagnosis	NN
cord-015021-pol2qm74	5890	14	of	of	IN
cord-015021-pol2qm74	5890	15	septic	septic	JJ
cord-015021-pol2qm74	5890	16	shock	shock	NN
cord-015021-pol2qm74	5890	17	or	or	CC
cord-015021-pol2qm74	5891	1	LOS.The	LOS.The	NNP
cord-015021-pol2qm74	5891	2	total	total	JJ
cord-015021-pol2qm74	5891	3	number	number	NN
cord-015021-pol2qm74	5891	4	of	of	IN
cord-015021-pol2qm74	5891	5	measurements	measurement	NNS
cord-015021-pol2qm74	5891	6	were	be	VBD
cord-015021-pol2qm74	5891	7	12	12	CD
cord-015021-pol2qm74	5891	8	points	point	NNS
cord-015021-pol2qm74	5891	9	in	in	IN
cord-015021-pol2qm74	5891	10	survival	survival	NN
cord-015021-pol2qm74	5891	11	septic	septic	NN
cord-015021-pol2qm74	5891	12	group	group	NN
cord-015021-pol2qm74	5891	13	,	,	,
cord-015021-pol2qm74	5892	1	l	l	NNP
cord-015021-pol2qm74	5892	2	l	l	NNP
cord-015021-pol2qm74	5892	3	points	point	NNS
cord-015021-pol2qm74	5892	4	in	in	IN
cord-015021-pol2qm74	5892	5	non	non	JJ
cord-015021-pol2qm74	5892	6	-	-	JJ
cord-015021-pol2qm74	5892	7	survival	survival	JJ
cord-015021-pol2qm74	5892	8	septic	septic	JJ
cord-015021-pol2qm74	5892	9	group	group	NN
cord-015021-pol2qm74	5892	10	and	and	CC
cord-015021-pol2qm74	5892	11	10	10	CD
cord-015021-pol2qm74	5892	12	points	point	NNS
cord-015021-pol2qm74	5892	13	in	in	IN
cord-015021-pol2qm74	5892	14	LOS	LOS	NNP
cord-015021-pol2qm74	5892	15	group	group	NN
cord-015021-pol2qm74	5892	16	.	.	.
cord-015021-pol2qm74	5893	1	Statistical	statistical	JJ
cord-015021-pol2qm74	5893	2	analysis	analysis	NN
cord-015021-pol2qm74	5893	3	was	be	VBD
cord-015021-pol2qm74	5893	4	used	use	VBN
cord-015021-pol2qm74	5893	5	student	student	NN
cord-015021-pol2qm74	5893	6	's	's	POS
cord-015021-pol2qm74	5893	7	t	t	NN
cord-015021-pol2qm74	5893	8	-	-	HYPH
cord-015021-pol2qm74	5893	9	test	test	NN
cord-015021-pol2qm74	5893	10	to	to	TO
cord-015021-pol2qm74	5893	11	compare	compare	VB
cord-015021-pol2qm74	5893	12	the	the	DT
cord-015021-pol2qm74	5893	13	mean	mean	NN
cord-015021-pol2qm74	5893	14	of	of	IN
cord-015021-pol2qm74	5893	15	each	each	DT
cord-015021-pol2qm74	5893	16	group	group	NN
cord-015021-pol2qm74	5893	17	,	,	,
cord-015021-pol2qm74	5893	18	and	and	CC
cord-015021-pol2qm74	5893	19	the	the	DT
cord-015021-pol2qm74	5893	20	changes	change	NNS
cord-015021-pol2qm74	5893	21	were	be	VBD
cord-015021-pol2qm74	5893	22	reported	report	VBN
cord-015021-pol2qm74	5893	23	as	as	IN
cord-015021-pol2qm74	5893	24	clinicat	clinicat	RB
cord-015021-pol2qm74	5893	25	significant	significant	JJ
cord-015021-pol2qm74	5893	26	if	if	IN
cord-015021-pol2qm74	5893	27	P<0.05	P<0.05	NNP
cord-015021-pol2qm74	5893	28	.	.	.
cord-015021-pol2qm74	5894	1	Results	result	NNS
cord-015021-pol2qm74	5894	2	:	:	:
cord-015021-pol2qm74	5895	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	5895	2	levels	level	NNS
cord-015021-pol2qm74	5895	3	in	in	IN
cord-015021-pol2qm74	5895	4	non	non	JJ
cord-015021-pol2qm74	5895	5	-	-	JJ
cord-015021-pol2qm74	5895	6	survival	survival	JJ
cord-015021-pol2qm74	5895	7	septic	septic	JJ
cord-015021-pol2qm74	5895	8	group	group	NN
cord-015021-pol2qm74	5895	9	were	be	VBD
cord-015021-pol2qm74	5895	10	higher	high	JJR
cord-015021-pol2qm74	5895	11	than	than	IN
cord-015021-pol2qm74	5895	12	in	in	IN
cord-015021-pol2qm74	5895	13	both	both	DT
cord-015021-pol2qm74	5895	14	survival	survival	NN
cord-015021-pol2qm74	5895	15	septic	septic	NN
cord-015021-pol2qm74	5895	16	and	and	CC
cord-015021-pol2qm74	5895	17	LOS	LOS	NNP
cord-015021-pol2qm74	5895	18	group.lL-6	group.ll-6	JJ
cord-015021-pol2qm74	5895	19	levels	level	NNS
cord-015021-pol2qm74	5895	20	in	in	IN
cord-015021-pol2qm74	5895	21	non	non	JJ
cord-015021-pol2qm74	5895	22	-	-	JJ
cord-015021-pol2qm74	5895	23	survival	survival	JJ
cord-015021-pol2qm74	5895	24	septic	septic	JJ
cord-015021-pol2qm74	5895	25	group	group	NN
cord-015021-pol2qm74	5895	26	were	be	VBD
cord-015021-pol2qm74	5895	27	more	more	RBR
cord-015021-pol2qm74	5895	28	significant	significant	JJ
cord-015021-pol2qm74	5895	29	than	than	IN
cord-015021-pol2qm74	5895	30	in	in	IN
cord-015021-pol2qm74	5895	31	both	both	DT
cord-015021-pol2qm74	5895	32	survival	survival	NN
cord-015021-pol2qm74	5895	33	and	and	CC
cord-015021-pol2qm74	5895	34	LOS	LOS	NNP
cord-015021-pol2qm74	5895	35	group	group	NN
cord-015021-pol2qm74	5895	36	.	.	.
cord-015021-pol2qm74	5896	1	Otherwise	otherwise	RB
cord-015021-pol2qm74	5896	2	,	,	,
cord-015021-pol2qm74	5896	3	there	there	EX
cord-015021-pol2qm74	5896	4	were	be	VBD
cord-015021-pol2qm74	5896	5	no	no	DT
cord-015021-pol2qm74	5896	6	differences	difference	NNS
cord-015021-pol2qm74	5896	7	with	with	IN
cord-015021-pol2qm74	5896	8	respect	respect	NN
cord-015021-pol2qm74	5896	9	to	to	IN
cord-015021-pol2qm74	5896	10	ACTH	ACTH	NNP
cord-015021-pol2qm74	5896	11	and	and	CC
cord-015021-pol2qm74	5896	12	cortisol	cortisol	NN
cord-015021-pol2qm74	5896	13	among	among	IN
cord-015021-pol2qm74	5896	14	three	three	CD
cord-015021-pol2qm74	5896	15	groups	group	NNS
cord-015021-pol2qm74	5896	16	.	.	.
cord-015021-pol2qm74	5897	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	5897	2	:	:	:
cord-015021-pol2qm74	5898	1	We	-PRON-	PRP
cord-015021-pol2qm74	5898	2	assumed	assume	VBD
cord-015021-pol2qm74	5898	3	that	that	IN
cord-015021-pol2qm74	5898	4	LOS	LOS	NNP
cord-015021-pol2qm74	5898	5	would	would	MD
cord-015021-pol2qm74	5898	6	make	make	VB
cord-015021-pol2qm74	5898	7	several	several	JJ
cord-015021-pol2qm74	5898	8	organs	organ	NNS
cord-015021-pol2qm74	5898	9	dysfunction	dysfunction	NN
cord-015021-pol2qm74	5898	10	as	as	RB
cord-015021-pol2qm74	5898	11	well	well	RB
cord-015021-pol2qm74	5898	12	as	as	IN
cord-015021-pol2qm74	5898	13	septic	septic	JJ
cord-015021-pol2qm74	5898	14	shock	shock	NN
cord-015021-pol2qm74	5898	15	.	.	.
cord-015021-pol2qm74	5899	1	But	but	CC
cord-015021-pol2qm74	5899	2	our	-PRON-	PRP$
cord-015021-pol2qm74	5899	3	results	result	NNS
cord-015021-pol2qm74	5899	4	showed	show	VBD
cord-015021-pol2qm74	5899	5	septic	septic	JJ
cord-015021-pol2qm74	5899	6	shock	shock	NN
cord-015021-pol2qm74	5899	7	,	,	,
cord-015021-pol2qm74	5899	8	especially	especially	RB
cord-015021-pol2qm74	5899	9	non	non	JJ
cord-015021-pol2qm74	5899	10	-	-	JJ
cord-015021-pol2qm74	5899	11	survival	survival	JJ
cord-015021-pol2qm74	5899	12	,	,	,
cord-015021-pol2qm74	5899	13	had	have	VBD
cord-015021-pol2qm74	5899	14	different	different	JJ
cord-015021-pol2qm74	5899	15	cytokins	cytokins	NNP
cord-015021-pol2qm74	5899	16	network	network	NN
cord-015021-pol2qm74	5899	17	mechanism	mechanism	NN
cord-015021-pol2qm74	5899	18	for	for	IN
cord-015021-pol2qm74	5899	19	organs	organ	NNS
cord-015021-pol2qm74	5899	20	failure	failure	NN
cord-015021-pol2qm74	5899	21	from	from	IN
cord-015021-pol2qm74	5899	22	LOS	LOS	NNP
cord-015021-pol2qm74	5899	23	.	.	.
cord-015021-pol2qm74	5900	1	Lasson	Lasson	NNP
cord-015021-pol2qm74	5900	2	,	,	,
cord-015021-pol2qm74	5900	3	~	~	NFP
cord-015021-pol2qm74	5900	4	,	,	,
cord-015021-pol2qm74	5900	5	G/3ransson	G/3ransson	NNP
cord-015021-pol2qm74	5900	6	J	J	NNP
cord-015021-pol2qm74	5900	7	,	,	,
cord-015021-pol2qm74	5900	8	JiJnsson	JiJnsson	NNP
cord-015021-pol2qm74	5900	9	K.	K.	NNP
cord-015021-pol2qm74	5900	10	Eady	Eady	NNP
cord-015021-pol2qm74	5901	1	diagnosis	diagnosis	NN
cord-015021-pol2qm74	5901	2	of	of	IN
cord-015021-pol2qm74	5901	3	complications	complication	NNS
cord-015021-pol2qm74	5901	4	after	after	IN
cord-015021-pol2qm74	5901	5	trauma	trauma	NN
cord-015021-pol2qm74	5901	6	is	be	VBZ
cord-015021-pol2qm74	5901	7	imperative	imperative	JJ
cord-015021-pol2qm74	5901	8	to	to	TO
cord-015021-pol2qm74	5901	9	decrease	decrease	VB
cord-015021-pol2qm74	5901	10	morbidity	morbidity	NN
cord-015021-pol2qm74	5901	11	and	and	CC
cord-015021-pol2qm74	5901	12	mortality	mortality	NN
cord-015021-pol2qm74	5901	13	.	.	.
cord-015021-pol2qm74	5902	1	For	for	IN
cord-015021-pol2qm74	5902	2	this	this	DT
cord-015021-pol2qm74	5902	3	purpose	purpose	NN
cord-015021-pol2qm74	5902	4	an	an	DT
cord-015021-pol2qm74	5902	5	easy	easy	JJ
cord-015021-pol2qm74	5902	6	,	,	,
cord-015021-pol2qm74	5902	7	cheap	cheap	JJ
cord-015021-pol2qm74	5902	8	and	and	CC
cord-015021-pol2qm74	5902	9	fast	fast	JJ
cord-015021-pol2qm74	5902	10	diagnostic	diagnostic	JJ
cord-015021-pol2qm74	5902	11	method	method	NN
cord-015021-pol2qm74	5902	12	is	be	VBZ
cord-015021-pol2qm74	5902	13	needed	need	VBN
cord-015021-pol2qm74	5902	14	.	.	.
cord-015021-pol2qm74	5903	1	The	the	DT
cord-015021-pol2qm74	5903	2	aim	aim	NN
cord-015021-pol2qm74	5903	3	of	of	IN
cord-015021-pol2qm74	5903	4	this	this	DT
cord-015021-pol2qm74	5903	5	study	study	NN
cord-015021-pol2qm74	5903	6	was	be	VBD
cord-015021-pol2qm74	5903	7	to	to	TO
cord-015021-pol2qm74	5903	8	analyse	analyse	VB
cord-015021-pol2qm74	5903	9	if	if	IN
cord-015021-pol2qm74	5903	10	complications	complication	NNS
cord-015021-pol2qm74	5903	11	after	after	IN
cord-015021-pol2qm74	5903	12	surgical	surgical	JJ
cord-015021-pol2qm74	5903	13	trauma	trauma	NN
cord-015021-pol2qm74	5903	14	of	of	IN
cord-015021-pol2qm74	5903	15	various	various	JJ
cord-015021-pol2qm74	5903	16	extent	extent	NN
cord-015021-pol2qm74	5903	17	could	could	MD
cord-015021-pol2qm74	5903	18	be	be	VB
cord-015021-pol2qm74	5903	19	diagnosed	diagnose	VBN
cord-015021-pol2qm74	5903	20	earlier	early	RBR
cord-015021-pol2qm74	5903	21	using	use	VBG
cord-015021-pol2qm74	5903	22	preoperative	preoperative	JJ
cord-015021-pol2qm74	5903	23	or	or	CC
cord-015021-pol2qm74	5903	24	daily	daily	JJ
cord-015021-pol2qm74	5903	25	postoperative	postoperative	JJ
cord-015021-pol2qm74	5903	26	measurements	measurement	NNS
cord-015021-pol2qm74	5903	27	of	of	IN
cord-015021-pol2qm74	5903	28	various	various	JJ
cord-015021-pol2qm74	5903	29	plasma	plasma	NN
cord-015021-pol2qm74	5903	30	proteins	protein	NNS
cord-015021-pol2qm74	5903	31	than	than	IN
cord-015021-pol2qm74	5903	32	by	by	IN
cord-015021-pol2qm74	5903	33	using	use	VBG
cord-015021-pol2qm74	5903	34	climcal	climcal	JJ
cord-015021-pol2qm74	5903	35	signs	sign	NNS
cord-015021-pol2qm74	5903	36	of	of	IN
cord-015021-pol2qm74	5903	37	complications	complication	NNS
cord-015021-pol2qm74	5903	38	.	.	.
cord-015021-pol2qm74	5904	1	Material	material	NN
cord-015021-pol2qm74	5904	2	and	and	CC
cord-015021-pol2qm74	5904	3	Methods	method	NNS
cord-015021-pol2qm74	5904	4	:	:	:
cord-015021-pol2qm74	5904	5	Two	two	CD
cord-015021-pol2qm74	5904	6	acute	acute	JJ
cord-015021-pol2qm74	5904	7	phase	phase	NN
cord-015021-pol2qm74	5904	8	proteins	protein	NNS
cord-015021-pol2qm74	5904	9	(	(	-LRB-
cord-015021-pol2qm74	5904	10	C	c	NN
cord-015021-pol2qm74	5904	11	-	-	HYPH
cord-015021-pol2qm74	5904	12	reactive	reactive	JJ
cord-015021-pol2qm74	5904	13	protein	protein	NN
cord-015021-pol2qm74	5904	14	and	and	CC
cord-015021-pol2qm74	5904	15	antichymotrypsin	antichymotrypsin	NNP
cord-015021-pol2qm74	5904	16	)	)	-RRB-
cord-015021-pol2qm74	5904	17	,	,	,
cord-015021-pol2qm74	5904	18	lbur	lbur	NNP
cord-015021-pol2qm74	5905	1	main	main	JJ
cord-015021-pol2qm74	5905	2	plasma	plasma	NN
cord-015021-pol2qm74	5905	3	protease	protease	NN
cord-015021-pol2qm74	5905	4	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5905	5	(	(	-LRB-
cord-015021-pol2qm74	5905	6	alpha-2-maeroglobulin	alpha-2-maeroglobulin	NNP
cord-015021-pol2qm74	5905	7	,	,	,
cord-015021-pol2qm74	5905	8	C	C	NNP
cord-015021-pol2qm74	5905	9	1estemse	1estemse	CD
cord-015021-pol2qm74	5905	10	inhibitor	inhibitor	NN
cord-015021-pol2qm74	5905	11	,	,	,
cord-015021-pol2qm74	5905	12	antithrombin	antithrombin	NN
cord-015021-pol2qm74	5905	13	Ill	Ill	NNP
cord-015021-pol2qm74	5905	14	and	and	CC
cord-015021-pol2qm74	5905	15	alpha-2-antiplasmin	alpha-2-antiplasmin	NNP
cord-015021-pol2qm74	5905	16	)	)	-RRB-
cord-015021-pol2qm74	5905	17	and	and	CC
cord-015021-pol2qm74	5905	18	one	one	CD
cord-015021-pol2qm74	5905	19	collagen	collagen	NN
cord-015021-pol2qm74	5905	20	precursor	precursor	NN
cord-015021-pol2qm74	5905	21	(	(	-LRB-
cord-015021-pol2qm74	5905	22	procollagen	procollagen	NNP
cord-015021-pol2qm74	5905	23	III	III	NNP
cord-015021-pol2qm74	5905	24	peptide	peptide	NN
cord-015021-pol2qm74	5905	25	)	)	-RRB-
cord-015021-pol2qm74	5905	26	were	be	VBD
cord-015021-pol2qm74	5905	27	measured	measure	VBN
cord-015021-pol2qm74	5905	28	preoperatively	preoperatively	RB
cord-015021-pol2qm74	5905	29	and	and	CC
cord-015021-pol2qm74	5905	30	then	then	RB
cord-015021-pol2qm74	5905	31	once	once	RB
cord-015021-pol2qm74	5905	32	dally	dally	VBP
cord-015021-pol2qm74	5905	33	for	for	IN
cord-015021-pol2qm74	5905	34	7	7	CD
cord-015021-pol2qm74	5905	35	days	day	NNS
cord-015021-pol2qm74	5905	36	postoperatively	postoperatively	RB
cord-015021-pol2qm74	5905	37	.	.	.
cord-015021-pol2qm74	5906	1	For	for	IN
cord-015021-pol2qm74	5906	2	the	the	DT
cord-015021-pol2qm74	5906	3	plasma	plasma	NN
cord-015021-pol2qm74	5906	4	protease	protease	NN
cord-015021-pol2qm74	5906	5	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5906	6	immunorcactive	immunorcactive	JJ
cord-015021-pol2qm74	5906	7	as	as	RB
cord-015021-pol2qm74	5906	8	well	well	RB
cord-015021-pol2qm74	5906	9	as	as	IN
cord-015021-pol2qm74	5906	10	functional	functional	JJ
cord-015021-pol2qm74	5906	11	levels	level	NNS
cord-015021-pol2qm74	5906	12	were	be	VBD
cord-015021-pol2qm74	5906	13	measured	measure	VBN
cord-015021-pol2qm74	5906	14	.	.	.
cord-015021-pol2qm74	5907	1	Haemoglbin	Haemoglbin	NNP
cord-015021-pol2qm74	5907	2	,	,	,
cord-015021-pol2qm74	5907	3	albumin	albumin	NN
cord-015021-pol2qm74	5907	4	and	and	CC
cord-015021-pol2qm74	5907	5	the	the	DT
cord-015021-pol2qm74	5907	6	white	white	JJ
cord-015021-pol2qm74	5907	7	blood	blood	NN
cord-015021-pol2qm74	5907	8	cell	cell	NN
cord-015021-pol2qm74	5907	9	count	count	NN
cord-015021-pol2qm74	5907	10	were	be	VBD
cord-015021-pol2qm74	5907	11	also	also	RB
cord-015021-pol2qm74	5907	12	measured	measure	VBN
cord-015021-pol2qm74	5907	13	.	.	.
cord-015021-pol2qm74	5908	1	Measurements	measurement	NNS
cord-015021-pol2qm74	5908	2	were	be	VBD
cord-015021-pol2qm74	5908	3	done	do	VBN
cord-015021-pol2qm74	5908	4	preoperatively	preoperatively	NN
cord-015021-pol2qm74	5908	5	in	in	IN
cord-015021-pol2qm74	5908	6	256	256	CD
cord-015021-pol2qm74	5908	7	patients	patient	NNS
cord-015021-pol2qm74	5908	8	and	and	CC
cord-015021-pol2qm74	5908	9	continued	continue	VBD
cord-015021-pol2qm74	5908	10	postoperatively	postoperatively	RB
cord-015021-pol2qm74	5908	11	in	in	IN
cord-015021-pol2qm74	5908	12	78	78	CD
cord-015021-pol2qm74	5908	13	patients	patient	NNS
cord-015021-pol2qm74	5908	14	,	,	,
cord-015021-pol2qm74	5908	15	70	70	CD
cord-015021-pol2qm74	5908	16	%	%	NN
cord-015021-pol2qm74	5908	17	of	of	IN
cord-015021-pol2qm74	5908	18	the	the	DT
cord-015021-pol2qm74	5908	19	patients	patient	NNS
cord-015021-pol2qm74	5908	20	were	be	VBD
cord-015021-pol2qm74	5908	21	operated	operate	VBN
cord-015021-pol2qm74	5908	22	on	on	IN
cord-015021-pol2qm74	5908	23	for	for	IN
cord-015021-pol2qm74	5908	24	malignancy	malignancy	NN
cord-015021-pol2qm74	5908	25	.	.	.
cord-015021-pol2qm74	5909	1	Resulls	resull	NNS
cord-015021-pol2qm74	5909	2	:	:	:
cord-015021-pol2qm74	5910	1	Preoperative	Preoperative	NNP
cord-015021-pol2qm74	5910	2	plasma	plasma	NN
cord-015021-pol2qm74	5910	3	C	c	NN
cord-015021-pol2qm74	5910	4	-	-	HYPH
cord-015021-pol2qm74	5910	5	reactive	reactive	JJ
cord-015021-pol2qm74	5910	6	protein	protein	NN
cord-015021-pol2qm74	5910	7	levels	level	NNS
cord-015021-pol2qm74	5910	8	were	be	VBD
cord-015021-pol2qm74	5910	9	higher	high	JJR
cord-015021-pol2qm74	5910	10	in	in	IN
cord-015021-pol2qm74	5910	11	patients	patient	NNS
cord-015021-pol2qm74	5910	12	developing	develop	VBG
cord-015021-pol2qm74	5910	13	postoperative	postoperative	JJ
cord-015021-pol2qm74	5910	14	complications	complication	NNS
cord-015021-pol2qm74	5910	15	.	.	.
cord-015021-pol2qm74	5911	1	This	this	DT
cord-015021-pol2qm74	5911	2	discrimination	discrimination	NN
cord-015021-pol2qm74	5911	3	increased	increase	VBD
cord-015021-pol2qm74	5911	4	when	when	WRB
cord-015021-pol2qm74	5911	5	plasma	plasma	NN
cord-015021-pol2qm74	5911	6	was	be	VBD
cord-015021-pol2qm74	5911	7	sequentially	sequentially	RB
cord-015021-pol2qm74	5911	8	analysed	analyse	VBN
cord-015021-pol2qm74	5911	9	postoperatively	postoperatively	RB
cord-015021-pol2qm74	5911	10	,	,	,
cord-015021-pol2qm74	5911	11	when	when	WRB
cord-015021-pol2qm74	5911	12	a	a	DT
cord-015021-pol2qm74	5911	13	remaining	remain	VBG
cord-015021-pol2qm74	5911	14	high	high	JJ
cord-015021-pol2qm74	5911	15	level	level	NN
cord-015021-pol2qm74	5911	16	ora	ora	NN
cord-015021-pol2qm74	5911	17	second	second	JJ
cord-015021-pol2qm74	5911	18	increase	increase	NN
cord-015021-pol2qm74	5911	19	in	in	IN
cord-015021-pol2qm74	5911	20	plasma	plasma	NN
cord-015021-pol2qm74	5911	21	levels	level	NNS
cord-015021-pol2qm74	5911	22	depicted	depict	VBD
cord-015021-pol2qm74	5911	23	a	a	DT
cord-015021-pol2qm74	5911	24	complication	complication	NN
cord-015021-pol2qm74	5911	25	1	1	CD
cord-015021-pol2qm74	5911	26	-	-	SYM
cord-015021-pol2qm74	5911	27	3	3	CD
cord-015021-pol2qm74	5911	28	days	day	NNS
cord-015021-pol2qm74	5911	29	earlier	early	RBR
cord-015021-pol2qm74	5911	30	than	than	IN
cord-015021-pol2qm74	5911	31	clinical	clinical	JJ
cord-015021-pol2qm74	5911	32	signs	sign	NNS
cord-015021-pol2qm74	5911	33	.	.	.
cord-015021-pol2qm74	5912	1	High	high	JJ
cord-015021-pol2qm74	5912	2	levels	level	NNS
cord-015021-pol2qm74	5912	3	were	be	VBD
cord-015021-pol2qm74	5912	4	seen	see	VBN
cord-015021-pol2qm74	5912	5	both	both	CC
cord-015021-pol2qm74	5912	6	in	in	IN
cord-015021-pol2qm74	5912	7	patients	patient	NNS
cord-015021-pol2qm74	5912	8	developing	develop	VBG
cord-015021-pol2qm74	5912	9	local	local	JJ
cord-015021-pol2qm74	5912	10	as	as	RB
cord-015021-pol2qm74	5912	11	well	well	RB
cord-015021-pol2qm74	5912	12	as	as	IN
cord-015021-pol2qm74	5912	13	in	in	IN
cord-015021-pol2qm74	5912	14	patients	patient	NNS
cord-015021-pol2qm74	5912	15	developing	develop	VBG
cord-015021-pol2qm74	5912	16	general	general	JJ
cord-015021-pol2qm74	5912	17	complications	complication	NNS
cord-015021-pol2qm74	5912	18	.	.	.
cord-015021-pol2qm74	5913	1	There	there	EX
cord-015021-pol2qm74	5913	2	was	be	VBD
cord-015021-pol2qm74	5913	3	no	no	DT
cord-015021-pol2qm74	5913	4	clear	clear	JJ
cord-015021-pol2qm74	5913	5	correlation	correlation	NN
cord-015021-pol2qm74	5913	6	between	between	IN
cord-015021-pol2qm74	5913	7	plasma	plasma	NN
cord-015021-pol2qm74	5913	8	protease	protease	NN
cord-015021-pol2qm74	5913	9	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	5913	10	levels	level	NNS
cord-015021-pol2qm74	5913	11	and	and	CC
cord-015021-pol2qm74	5913	12	complications	complication	NNS
cord-015021-pol2qm74	5913	13	,	,	,
cord-015021-pol2qm74	5913	14	neither	neither	CC
cord-015021-pol2qm74	5913	15	pre	pre	VB
cord-015021-pol2qm74	5913	16	-	-	:
cord-015021-pol2qm74	5913	17	nor	nor	CC
cord-015021-pol2qm74	5913	18	postoperatively	postoperatively	RB
cord-015021-pol2qm74	5913	19	.	.	.
cord-015021-pol2qm74	5914	1	Procollagen	Procollagen	NNP
cord-015021-pol2qm74	5914	2	III	III	NNP
cord-015021-pol2qm74	5914	3	paptide	paptide	NN
cord-015021-pol2qm74	5914	4	levels	level	NNS
cord-015021-pol2qm74	5914	5	were	be	VBD
cord-015021-pol2qm74	5914	6	slightly	slightly	RB
cord-015021-pol2qm74	5914	7	(	(	-LRB-
cord-015021-pol2qm74	5914	8	but	but	CC
cord-015021-pol2qm74	5914	9	not	not	RB
cord-015021-pol2qm74	5914	10	significantly	significantly	RB
cord-015021-pol2qm74	5914	11	)	)	-RRB-
cord-015021-pol2qm74	5914	12	higher	high	JJR
cord-015021-pol2qm74	5914	13	postoperatively	postoperatively	RB
cord-015021-pol2qm74	5914	14	in	in	IN
cord-015021-pol2qm74	5914	15	patients	patient	NNS
cord-015021-pol2qm74	5914	16	developing	develop	VBG
cord-015021-pol2qm74	5914	17	complications	complication	NNS
cord-015021-pol2qm74	5914	18	.	.	.
cord-015021-pol2qm74	5915	1	Contusions	contusion	NNS
cord-015021-pol2qm74	5915	2	:	:	:
cord-015021-pol2qm74	5916	1	The	the	DT
cord-015021-pol2qm74	5916	2	acute	acute	JJ
cord-015021-pol2qm74	5916	3	phase	phase	NN
cord-015021-pol2qm74	5916	4	response	response	NN
cord-015021-pol2qm74	5916	5	,	,	,
cord-015021-pol2qm74	5916	6	especially	especially	RB
cord-015021-pol2qm74	5916	7	concerning	concern	VBG
cord-015021-pol2qm74	5916	8	C	c	NN
cord-015021-pol2qm74	5916	9	-	-	HYPH
cord-015021-pol2qm74	5916	10	reactive	reactive	JJ
cord-015021-pol2qm74	5916	11	protein	protein	NN
cord-015021-pol2qm74	5916	12	,	,	,
cord-015021-pol2qm74	5916	13	predicts	predict	VBZ
cord-015021-pol2qm74	5916	14	postoperative	postoperative	JJ
cord-015021-pol2qm74	5916	15	complications	complication	NNS
cord-015021-pol2qm74	5916	16	better	well	RBR
cord-015021-pol2qm74	5916	17	than	than	IN
cord-015021-pol2qm74	5916	18	both	both	CC
cord-015021-pol2qm74	5916	19	plasma	plasma	NN
cord-015021-pol2qm74	5916	20	protease	protease	NN
cord-015021-pol2qm74	5916	21	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	5916	22	or	or	CC
cord-015021-pol2qm74	5916	23	collagen	collagen	NN
cord-015021-pol2qm74	5916	24	precursors	precursor	NNS
cord-015021-pol2qm74	5916	25	.	.	.
cord-015021-pol2qm74	5917	1	Preoperative	Preoperative	NNP
cord-015021-pol2qm74	5917	2	plasma	plasma	NN
cord-015021-pol2qm74	5917	3	C	c	NN
cord-015021-pol2qm74	5917	4	-	-	HYPH
cord-015021-pol2qm74	5917	5	reactive	reactive	JJ
cord-015021-pol2qm74	5917	6	protein	protein	NN
cord-015021-pol2qm74	5917	7	levels	level	NNS
cord-015021-pol2qm74	5917	8	indicate	indicate	VBP
cord-015021-pol2qm74	5917	9	the	the	DT
cord-015021-pol2qm74	5917	10	risk	risk	NN
cord-015021-pol2qm74	5917	11	of	of	IN
cord-015021-pol2qm74	5917	12	postoperative	postoperative	JJ
cord-015021-pol2qm74	5917	13	complications	complication	NNS
cord-015021-pol2qm74	5917	14	,	,	,
cord-015021-pol2qm74	5917	15	while	while	IN
cord-015021-pol2qm74	5917	16	daily	daily	JJ
cord-015021-pol2qm74	5917	17	postoperative	postoperative	JJ
cord-015021-pol2qm74	5917	18	measurements	measurement	NNS
cord-015021-pol2qm74	5917	19	more	more	RBR
cord-015021-pol2qm74	5917	20	readily	readily	RB
cord-015021-pol2qm74	5917	21	depicts	depict	VBZ
cord-015021-pol2qm74	5917	22	a	a	DT
cord-015021-pol2qm74	5917	23	complication	complication	NN
cord-015021-pol2qm74	5917	24	,	,	,
cord-015021-pol2qm74	5917	25	usually	usually	RB
cord-015021-pol2qm74	5917	26	preceeding	preceede	VBG
cord-015021-pol2qm74	5917	27	the	the	DT
cord-015021-pol2qm74	5917	28	clinical	clinical	JJ
cord-015021-pol2qm74	5917	29	signs	sign	NNS
cord-015021-pol2qm74	5917	30	of	of	IN
cord-015021-pol2qm74	5917	31	complication	complication	NN
cord-015021-pol2qm74	5917	32	by	by	IN
cord-015021-pol2qm74	5917	33	1	1	CD
cord-015021-pol2qm74	5917	34	-	-	SYM
cord-015021-pol2qm74	5917	35	3	3	CD
cord-015021-pol2qm74	5917	36	days	day	NNS
cord-015021-pol2qm74	5917	37	.	.	.
cord-015021-pol2qm74	5918	1	Dept	Dept	NNP
cord-015021-pol2qm74	5918	2	.	.	.
cord-015021-pol2qm74	5919	1	of	of	IN
cord-015021-pol2qm74	5919	2	Surgery	Surgery	NNP
cord-015021-pol2qm74	5919	3	M'alm6	M'alm6	NNP
cord-015021-pol2qm74	5919	4	General	General	NNP
cord-015021-pol2qm74	5919	5	Hospital	Hospital	NNP
cord-015021-pol2qm74	5919	6	,	,	,
cord-015021-pol2qm74	5919	7	S-2	S-2	NNP
cord-015021-pol2qm74	5919	8	I4	I4	NNP
cord-015021-pol2qm74	5919	9	01	01	CD
cord-015021-pol2qm74	5919	10	Malmr	Malmr	NNP
cord-015021-pol2qm74	5919	11	,	,	,
cord-015021-pol2qm74	5919	12	Sweden	Sweden	NNP
cord-015021-pol2qm74	5919	13	.	.	.
cord-015021-pol2qm74	5920	1	MOF	MOF	NNP
cord-015021-pol2qm74	5920	2	is	be	VBZ
cord-015021-pol2qm74	5920	3	a	a	DT
cord-015021-pol2qm74	5920	4	major	major	JJ
cord-015021-pol2qm74	5920	5	threat	threat	NN
cord-015021-pol2qm74	5920	6	to	to	IN
cord-015021-pol2qm74	5920	7	the	the	DT
cord-015021-pol2qm74	5920	8	extensive	extensive	JJ
cord-015021-pol2qm74	5920	9	burned	burn	VBN
cord-015021-pol2qm74	5920	10	patients	patient	NNS
cord-015021-pol2qm74	5920	11	and	and	CC
cord-015021-pol2qm74	5920	12	associated	associate	VBN
cord-015021-pol2qm74	5920	13	with	with	IN
cord-015021-pol2qm74	5920	14	a	a	DT
cord-015021-pol2qm74	5920	15	high	high	JJ
cord-015021-pol2qm74	5920	16	mortality	mortality	NN
cord-015021-pol2qm74	5920	17	rate	rate	NN
cord-015021-pol2qm74	5920	18	.	.	.
cord-015021-pol2qm74	5921	1	The	the	DT
cord-015021-pol2qm74	5921	2	role	role	NN
cord-015021-pol2qm74	5921	3	of	of	IN
cord-015021-pol2qm74	5921	4	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	5921	5	in	in	IN
cord-015021-pol2qm74	5921	6	the	the	DT
cord-015021-pol2qm74	5921	7	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	5921	8	of	of	IN
cord-015021-pol2qm74	5921	9	MOF	MOF	NNP
cord-015021-pol2qm74	5921	10	in	in	IN
cord-015021-pol2qm74	5921	11	burned	burn	VBN
cord-015021-pol2qm74	5921	12	patients	patient	NNS
cord-015021-pol2qm74	5921	13	remains	remain	VBZ
cord-015021-pol2qm74	5921	14	controversial	controversial	JJ
cord-015021-pol2qm74	5921	15	.	.	.
cord-015021-pol2qm74	5922	1	In	in	IN
cord-015021-pol2qm74	5922	2	this	this	DT
cord-015021-pol2qm74	5922	3	study	study	NN
cord-015021-pol2qm74	5922	4	,	,	,
cord-015021-pol2qm74	5922	5	We	-PRON-	PRP
cord-015021-pol2qm74	5922	6	examined	examine	VBD
cord-015021-pol2qm74	5922	7	the	the	DT
cord-015021-pol2qm74	5922	8	relationship	relationship	NN
cord-015021-pol2qm74	5922	9	of	of	IN
cord-015021-pol2qm74	5922	10	plasma	plasma	NN
cord-015021-pol2qm74	5922	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5922	12	levels	level	NNS
cord-015021-pol2qm74	5922	13	to	to	IN
cord-015021-pol2qm74	5922	14	development	development	NN
cord-015021-pol2qm74	5922	15	of	of	IN
cord-015021-pol2qm74	5922	16	MOF	MOF	NNP
cord-015021-pol2qm74	5922	17	,	,	,
cord-015021-pol2qm74	5922	18	and	and	CC
cord-015021-pol2qm74	5922	19	outcome	outcome	NN
cord-015021-pol2qm74	5922	20	in	in	IN
cord-015021-pol2qm74	5922	21	patients	patient	NNS
cord-015021-pol2qm74	5922	22	with	with	IN
cord-015021-pol2qm74	5922	23	thermal	thermal	JJ
cord-015021-pol2qm74	5922	24	injury	injury	NN
cord-015021-pol2qm74	5922	25	.	.	.
cord-015021-pol2qm74	5923	1	Methods	method	NNS
cord-015021-pol2qm74	5923	2	:	:	:
cord-015021-pol2qm74	5924	1	A	a	DT
cord-015021-pol2qm74	5924	2	prospective	prospective	JJ
cord-015021-pol2qm74	5924	3	cohort	cohort	NN
cord-015021-pol2qm74	5924	4	study	study	NN
cord-015021-pol2qm74	5924	5	of	of	IN
cord-015021-pol2qm74	5924	6	17	17	CD
cord-015021-pol2qm74	5924	7	patients	patient	NNS
cord-015021-pol2qm74	5924	8	admitted	admit	VBN
cord-015021-pol2qm74	5924	9	with	with	IN
cord-015021-pol2qm74	5924	10	burns	burn	NNS
cord-015021-pol2qm74	5924	11	covering	cover	VBG
cord-015021-pol2qm74	5924	12	more	more	JJR
cord-015021-pol2qm74	5924	13	than	than	IN
cord-015021-pol2qm74	5924	14	70	70	CD
cord-015021-pol2qm74	5924	15	per	per	IN
cord-015021-pol2qm74	5924	16	cent	cent	NN
cord-015021-pol2qm74	5924	17	of	of	IN
cord-015021-pol2qm74	5924	18	body	body	NN
cord-015021-pol2qm74	5924	19	surface	surface	NN
cord-015021-pol2qm74	5924	20	area	area	NN
cord-015021-pol2qm74	5924	21	was	be	VBD
cord-015021-pol2qm74	5924	22	undertaken	undertake	VBN
cord-015021-pol2qm74	5924	23	.	.	.
cord-015021-pol2qm74	5925	1	Circulating	circulate	VBG
cord-015021-pol2qm74	5925	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5925	3	concentrations	concentration	NNS
cord-015021-pol2qm74	5925	4	were	be	VBD
cord-015021-pol2qm74	5925	5	measured	measure	VBN
cord-015021-pol2qm74	5925	6	by	by	IN
cord-015021-pol2qm74	5925	7	modified	modify	VBN
cord-015021-pol2qm74	5925	8	limulus	limulus	NNP
cord-015021-pol2qm74	5925	9	amebocyte	amebocyte	NNP
cord-015021-pol2qm74	5925	10	lysate	lysate	NN
cord-015021-pol2qm74	5925	11	assay	assay	NN
cord-015021-pol2qm74	5925	12	in	in	IN
cord-015021-pol2qm74	5925	13	serial	serial	JJ
cord-015021-pol2qm74	5925	14	samples	sample	NNS
cord-015021-pol2qm74	5925	15	of	of	IN
cord-015021-pol2qm74	5925	16	plasma	plasma	NN
cord-015021-pol2qm74	5925	17	.	.	.
cord-015021-pol2qm74	5926	1	Results	result	NNS
cord-015021-pol2qm74	5926	2	:	:	:
cord-015021-pol2qm74	5926	3	7	7	CD
cord-015021-pol2qm74	5926	4	out	out	IN
cord-015021-pol2qm74	5926	5	of	of	IN
cord-015021-pol2qm74	5926	6	17	17	CD
cord-015021-pol2qm74	5926	7	burned	burn	VBN
cord-015021-pol2qm74	5926	8	patients	patient	NNS
cord-015021-pol2qm74	5926	9	developed	develop	VBD
cord-015021-pol2qm74	5926	10	MOF	MOF	NNP
cord-015021-pol2qm74	5926	11	according	accord	VBG
cord-015021-pol2qm74	5926	12	to	to	IN
cord-015021-pol2qm74	5926	13	multiple	multiple	JJ
cord-015021-pol2qm74	5926	14	criteria	criterion	NNS
cord-015021-pol2qm74	5926	15	.	.	.
cord-015021-pol2qm74	5927	1	The	the	DT
cord-015021-pol2qm74	5927	2	plasma	plasma	NN
cord-015021-pol2qm74	5927	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5927	4	concentrations	concentration	NNS
cord-015021-pol2qm74	5927	5	of	of	IN
cord-015021-pol2qm74	5927	6	patients	patient	NNS
cord-015021-pol2qm74	5927	7	with	with	IN
cord-015021-pol2qm74	5927	8	MOF	MOF	NNP
cord-015021-pol2qm74	5927	9	were	be	VBD
cord-015021-pol2qm74	5927	10	0.512	0.512	CD
cord-015021-pol2qm74	5927	11	-	-	HYPH
cord-015021-pol2qm74	5927	12	-1.127	-1.127	NNP
cord-015021-pol2qm74	5927	13	EU	EU	NNP
cord-015021-pol2qm74	5927	14	/	/	SYM
cord-015021-pol2qm74	5927	15	ml	ml	NNS
cord-015021-pol2qm74	5927	16	,	,	,
cord-015021-pol2qm74	5927	17	significantly	significantly	RB
cord-015021-pol2qm74	5927	18	higher	high	JJR
cord-015021-pol2qm74	5927	19	than	than	IN
cord-015021-pol2qm74	5927	20	that	that	DT
cord-015021-pol2qm74	5927	21	of	of	IN
cord-015021-pol2qm74	5927	22	10	10	CD
cord-015021-pol2qm74	5927	23	patients	patient	NNS
cord-015021-pol2qm74	5927	24	without	without	IN
cord-015021-pol2qm74	5927	25	MOF	MOF	NNP
cord-015021-pol2qm74	5927	26	(	(	-LRB-
cord-015021-pol2qm74	5927	27	0.216	0.216	CD
cord-015021-pol2qm74	5927	28	-	-	SYM
cord-015021-pol2qm74	5927	29	0.553	0.553	CD
cord-015021-pol2qm74	5927	30	EU	EU	NNP
cord-015021-pol2qm74	5927	31	/	/	SYM
cord-015021-pol2qm74	5927	32	ml	ml	NN
cord-015021-pol2qm74	5927	33	)	)	-RRB-
cord-015021-pol2qm74	5927	34	on	on	IN
cord-015021-pol2qm74	5927	35	3	3	CD
cord-015021-pol2qm74	5927	36	,	,	,
cord-015021-pol2qm74	5927	37	14	14	CD
cord-015021-pol2qm74	5927	38	,	,	,
cord-015021-pol2qm74	5927	39	21	21	CD
cord-015021-pol2qm74	5927	40	and	and	CC
cord-015021-pol2qm74	5927	41	28	28	CD
cord-015021-pol2qm74	5927	42	days	day	NNS
cord-015021-pol2qm74	5927	43	postburn	postburn	NN
cord-015021-pol2qm74	5927	44	(	(	-LRB-
cord-015021-pol2qm74	5927	45	p	p	NN
cord-015021-pol2qm74	5927	46	<	<	XX
cord-015021-pol2qm74	5927	47	0.05	0.05	CD
cord-015021-pol2qm74	5927	48	-	-	HYPH
cord-015021-pol2qm74	5927	49	-0.01	-0.01	CD
cord-015021-pol2qm74	5927	50	)	)	-RRB-
cord-015021-pol2qm74	5927	51	.	.	.
cord-015021-pol2qm74	5928	1	Significantly	significantly	RB
cord-015021-pol2qm74	5928	2	more	more	JJR
cord-015021-pol2qm74	5928	3	incidence	incidence	NN
cord-015021-pol2qm74	5928	4	of	of	IN
cord-015021-pol2qm74	5928	5	positive	positive	JJ
cord-015021-pol2qm74	5928	6	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5928	7	test	test	NN
cord-015021-pol2qm74	5928	8	(	(	-LRB-
cord-015021-pol2qm74	5928	9	>	>	XX
cord-015021-pol2qm74	5929	1	_	_	NN
cord-015021-pol2qm74	5929	2	0.120	0.120	CD
cord-015021-pol2qm74	5929	3	EU	EU	NNP
cord-015021-pol2qm74	5929	4	/	/	SYM
cord-015021-pol2qm74	5929	5	ml	ml	NN
cord-015021-pol2qm74	5929	6	)	)	-RRB-
cord-015021-pol2qm74	5929	7	was	be	VBD
cord-015021-pol2qm74	5929	8	found	find	VBN
cord-015021-pol2qm74	5929	9	in	in	IN
cord-015021-pol2qm74	5929	10	patients	patient	NNS
cord-015021-pol2qm74	5929	11	who	who	WP
cord-015021-pol2qm74	5929	12	developed	develop	VBD
cord-015021-pol2qm74	5929	13	MOF	MOF	NNP
cord-015021-pol2qm74	5929	14	as	as	IN
cord-015021-pol2qm74	5929	15	compared	compare	VBN
cord-015021-pol2qm74	5929	16	to	to	IN
cord-015021-pol2qm74	5929	17	that	that	DT
cord-015021-pol2qm74	5929	18	of	of	IN
cord-015021-pol2qm74	5929	19	Non	Non	NNP
cord-015021-pol2qm74	5929	20	-	-	NNP
cord-015021-pol2qm74	5929	21	MOF	MOF	NNP
cord-015021-pol2qm74	5929	22	during	during	IN
cord-015021-pol2qm74	5929	23	the	the	DT
cord-015021-pol2qm74	5929	24	observation	observation	NN
cord-015021-pol2qm74	5929	25	period	period	NN
cord-015021-pol2qm74	5929	26	(	(	-LRB-
cord-015021-pol2qm74	5929	27	p<0.05	p<0.05	CD
cord-015021-pol2qm74	5929	28	)	)	-RRB-
cord-015021-pol2qm74	5929	29	.	.	.
cord-015021-pol2qm74	5930	1	As	as	IN
cord-015021-pol2qm74	5930	2	the	the	DT
cord-015021-pol2qm74	5930	3	mean	mean	JJ
cord-015021-pol2qm74	5930	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5930	5	levels	level	NNS
cord-015021-pol2qm74	5930	6	increased	increase	VBD
cord-015021-pol2qm74	5930	7	,	,	,
cord-015021-pol2qm74	5930	8	the	the	DT
cord-015021-pol2qm74	5930	9	prevalence	prevalence	NN
cord-015021-pol2qm74	5930	10	of	of	IN
cord-015021-pol2qm74	5930	11	MOF	MOF	NNP
cord-015021-pol2qm74	5930	12	and	and	CC
cord-015021-pol2qm74	5930	13	death	death	NN
cord-015021-pol2qm74	5930	14	also	also	RB
cord-015021-pol2qm74	5930	15	increased	increase	VBD
cord-015021-pol2qm74	5930	16	(	(	-LRB-
cord-015021-pol2qm74	5930	17	see	see	VB
cord-015021-pol2qm74	5930	18	table	table	NN
cord-015021-pol2qm74	5930	19	below	below	RB
cord-015021-pol2qm74	5930	20	)	)	-RRB-
cord-015021-pol2qm74	5930	21	,	,	,
cord-015021-pol2qm74	5930	22	persistent	persistent	JJ
cord-015021-pol2qm74	5930	23	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	5930	24	carried	carry	VBD
cord-015021-pol2qm74	5930	25	a	a	DT
cord-015021-pol2qm74	5930	26	poor	poor	JJ
cord-015021-pol2qm74	5930	27	prognosis	prognosis	NN
cord-015021-pol2qm74	5930	28	.	.	.
cord-015021-pol2qm74	5931	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	5931	2	:	:	:
cord-015021-pol2qm74	5932	1	The	the	DT
cord-015021-pol2qm74	5932	2	present	present	JJ
cord-015021-pol2qm74	5932	3	investigation	investigation	NN
cord-015021-pol2qm74	5932	4	provide	provide	VBP
cord-015021-pol2qm74	5932	5	further	further	JJ
cord-015021-pol2qm74	5932	6	evidence	evidence	NN
cord-015021-pol2qm74	5932	7	that	that	IN
cord-015021-pol2qm74	5932	8	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	5932	9	in	in	IN
cord-015021-pol2qm74	5932	10	severely	severely	RB
cord-015021-pol2qm74	5932	11	burned	burn	VBN
cord-015021-pol2qm74	5932	12	patients	patient	NNS
cord-015021-pol2qm74	5932	13	commonly	commonly	RB
cord-015021-pol2qm74	5932	14	occur	occur	VBP
cord-015021-pol2qm74	5932	15	.	.	.
cord-015021-pol2qm74	5933	1	Cimulating	Cimulating	NNP
cord-015021-pol2qm74	5933	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	5933	3	has	have	VBZ
cord-015021-pol2qm74	5933	4	also	also	RB
cord-015021-pol2qm74	5933	5	been	be	VBN
cord-015021-pol2qm74	5933	6	found	find	VBN
cord-015021-pol2qm74	5933	7	to	to	TO
cord-015021-pol2qm74	5933	8	be	be	VB
cord-015021-pol2qm74	5933	9	strongly	strongly	RB
cord-015021-pol2qm74	5933	10	associated	associate	VBN
cord-015021-pol2qm74	5933	11	with	with	IN
cord-015021-pol2qm74	5933	12	development	development	NN
cord-015021-pol2qm74	5933	13	of	of	IN
cord-015021-pol2qm74	5933	14	MOF	MOF	NNP
cord-015021-pol2qm74	5933	15	and	and	CC
cord-015021-pol2qm74	5933	16	mortality	mortality	NN
cord-015021-pol2qm74	5933	17	following	follow	VBG
cord-015021-pol2qm74	5933	18	major	major	JJ
cord-015021-pol2qm74	5933	19	burn	burn	NN
cord-015021-pol2qm74	5933	20	injury	injury	NN
cord-015021-pol2qm74	5933	21	.	.	.
cord-015021-pol2qm74	5934	1	Multiple	multiple	JJ
cord-015021-pol2qm74	5934	2	hemostatic	hemostatic	JJ
cord-015021-pol2qm74	5934	3	changes	change	NNS
cord-015021-pol2qm74	5934	4	occur	occur	VBP
cord-015021-pol2qm74	5934	5	in	in	IN
cord-015021-pol2qm74	5934	6	sepsis	sepsis	NN
cord-015021-pol2qm74	5934	7	mad	mad	JJ
cord-015021-pol2qm74	5934	8	multiple	multiple	JJ
cord-015021-pol2qm74	5934	9	organ	organ	NN
cord-015021-pol2qm74	5934	10	failure	failure	NN
cord-015021-pol2qm74	5934	11	(	(	-LRB-
cord-015021-pol2qm74	5934	12	MOF	MOF	NNP
cord-015021-pol2qm74	5934	13	)	)	-RRB-
cord-015021-pol2qm74	5934	14	.	.	.
cord-015021-pol2qm74	5935	1	To	to	TO
cord-015021-pol2qm74	5935	2	evaluate	evaluate	VB
cord-015021-pol2qm74	5935	3	the	the	DT
cord-015021-pol2qm74	5935	4	role	role	NN
cord-015021-pol2qm74	5935	5	of	of	IN
cord-015021-pol2qm74	5935	6	platelcts	platelct	NNS
cord-015021-pol2qm74	5935	7	in	in	IN
cord-015021-pol2qm74	5935	8	patients	patient	NNS
cord-015021-pol2qm74	5935	9	with	with	IN
cord-015021-pol2qm74	5935	10	sepsis	sepsis	NN
cord-015021-pol2qm74	5935	11	and	and	CC
cord-015021-pol2qm74	5935	12	MOF	MOF	NNP
cord-015021-pol2qm74	5935	13	,	,	,
cord-015021-pol2qm74	5935	14	we	-PRON-	PRP
cord-015021-pol2qm74	5935	15	examined	examine	VBD
cord-015021-pol2qm74	5935	16	changes	change	NNS
cord-015021-pol2qm74	5935	17	in	in	IN
cord-015021-pol2qm74	5935	18	surface	surface	NN
cord-015021-pol2qm74	5935	19	glyeoproteins	glyeoprotein	NNS
cord-015021-pol2qm74	5935	20	on	on	IN
cord-015021-pol2qm74	5935	21	circulating	circulate	VBG
cord-015021-pol2qm74	5935	22	platelets	platelet	NNS
cord-015021-pol2qm74	5935	23	of	of	IN
cord-015021-pol2qm74	5935	24	t4	t4	NNP
cord-015021-pol2qm74	5935	25	patients	patient	NNS
cord-015021-pol2qm74	5935	26	with	with	IN
cord-015021-pol2qm74	5935	27	suspected	suspect	VBN
cord-015021-pol2qm74	5935	28	sepsis	sepsis	NN
cord-015021-pol2qm74	5935	29	and	and	CC
cord-015021-pol2qm74	5935	30	MOF	MOF	NNP
cord-015021-pol2qm74	5935	31	.	.	.
cord-015021-pol2qm74	5936	1	The	the	DT
cord-015021-pol2qm74	5936	2	severity	severity	NN
cord-015021-pol2qm74	5936	3	of	of	IN
cord-015021-pol2qm74	5936	4	sepsis	sepsis	NN
cord-015021-pol2qm74	5936	5	and	and	CC
cord-015021-pol2qm74	5936	6	MOF	MOF	NNP
cord-015021-pol2qm74	5936	7	was	be	VBD
cord-015021-pol2qm74	5936	8	assessed	assess	VBN
cord-015021-pol2qm74	5936	9	by	by	IN
cord-015021-pol2qm74	5936	10	Eiebute	Eiebute	NNP
cord-015021-pol2qm74	5936	11	and	and	CC
cord-015021-pol2qm74	5936	12	APACHE	APACHE	NNP
cord-015021-pol2qm74	5936	13	1I	1i	CD
cord-015021-pol2qm74	5936	14	scoring	score	VBG
cord-015021-pol2qm74	5936	15	system	system	NN
cord-015021-pol2qm74	5936	16	,	,	,
cord-015021-pol2qm74	5936	17	respectively	respectively	RB
cord-015021-pol2qm74	5936	18	.	.	.
cord-015021-pol2qm74	5937	1	Using	use	VBG
cord-015021-pol2qm74	5937	2	flow	flow	NN
cord-015021-pol2qm74	5937	3	cytometric	cytometric	NN
cord-015021-pol2qm74	5937	4	techniques	technique	NNS
cord-015021-pol2qm74	5937	5	and	and	CC
cord-015021-pol2qm74	5937	6	platelets	platelet	NNS
cord-015021-pol2qm74	5937	7	specific	specific	JJ
cord-015021-pol2qm74	5937	8	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	5937	9	antibodies	antibody	NNS
cord-015021-pol2qm74	5937	10	,	,	,
cord-015021-pol2qm74	5937	11	platelet	platelet	NN
cord-015021-pol2qm74	5937	12	surface	surface	NN
cord-015021-pol2qm74	5937	13	expression	expression	NN
cord-015021-pol2qm74	5937	14	of	of	IN
cord-015021-pol2qm74	5937	15	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	5937	16	receptor	receptor	NN
cord-015021-pol2qm74	5937	17	on	on	IN
cord-015021-pol2qm74	5937	18	GPIIb	GPIIb	NNP
cord-015021-pol2qm74	5937	19	-	-	HYPH
cord-015021-pol2qm74	5937	20	IIIa	iiia	NN
cord-015021-pol2qm74	5937	21	,	,	,
cord-015021-pol2qm74	5937	22	ofvon	ofvon	NN
cord-015021-pol2qm74	5937	23	Willebrand	Willebrand	NNP
cord-015021-pol2qm74	5937	24	receptor	receptor	NN
cord-015021-pol2qm74	5937	25	GPIb	GPIb	NNS
cord-015021-pol2qm74	5937	26	,	,	,
cord-015021-pol2qm74	5937	27	and	and	CC
cord-015021-pol2qm74	5937	28	of	of	IN
cord-015021-pol2qm74	5937	29	granula	granula	NN
cord-015021-pol2qm74	5937	30	glycoproteins	glycoprotein	NNS
cord-015021-pol2qm74	5937	31	(	(	-LRB-
cord-015021-pol2qm74	5937	32	thrombospondin	thrombospondin	NNP
cord-015021-pol2qm74	5937	33	,	,	,
cord-015021-pol2qm74	5937	34	GMP-140	GMP-140	NNP
cord-015021-pol2qm74	5937	35	,	,	,
cord-015021-pol2qm74	5937	36	and	and	CC
cord-015021-pol2qm74	5937	37	GP53	GP53	NNP
cord-015021-pol2qm74	5937	38	)	)	-RRB-
cord-015021-pol2qm74	5937	39	was	be	VBD
cord-015021-pol2qm74	5937	40	measured	measure	VBN
cord-015021-pol2qm74	5937	41	.	.	.
cord-015021-pol2qm74	5938	1	Receptor	receptor	NN
cord-015021-pol2qm74	5938	2	density	density	NN
cord-015021-pol2qm74	5938	3	of	of	IN
cord-015021-pol2qm74	5938	4	GPIIb	GPIIb	NNP
cord-015021-pol2qm74	5938	5	-	-	HYPH
cord-015021-pol2qm74	5938	6	Illa	Illa	NNP
cord-015021-pol2qm74	5938	7	mad	mad	JJ
cord-015021-pol2qm74	5938	8	GPIb	GPIb	NNS
cord-015021-pol2qm74	5938	9	on	on	IN
cord-015021-pol2qm74	5938	10	circulating	circulate	VBG
cord-015021-pol2qm74	5938	11	platelets	platelet	NNS
cord-015021-pol2qm74	5938	12	was	be	VBD
cord-015021-pol2qm74	5938	13	not	not	RB
cord-015021-pol2qm74	5938	14	affected	affect	VBN
cord-015021-pol2qm74	5938	15	by	by	IN
cord-015021-pol2qm74	5938	16	sepsis	sepsis	NN
cord-015021-pol2qm74	5938	17	or	or	CC
cord-015021-pol2qm74	5938	18	MOF	MOF	NNP
cord-015021-pol2qm74	5938	19	.	.	.
cord-015021-pol2qm74	5939	1	In	in	IN
cord-015021-pol2qm74	5939	2	septic	septic	JJ
cord-015021-pol2qm74	5939	3	patients	patient	NNS
cord-015021-pol2qm74	5939	4	surface	surface	VBP
cord-015021-pol2qm74	5939	5	expression	expression	NN
cord-015021-pol2qm74	5939	6	of	of	IN
cord-015021-pol2qm74	5939	7	activated	activate	VBN
cord-015021-pol2qm74	5939	8	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	5939	9	receptor	receptor	NN
cord-015021-pol2qm74	5939	10	(	(	-LRB-
cord-015021-pol2qm74	5939	11	LIBS1	libs1	JJ
cord-015021-pol2qm74	5939	12	expression	expression	NN
cord-015021-pol2qm74	5939	13	)	)	-RRB-
cord-015021-pol2qm74	5939	14	was	be	VBD
cord-015021-pol2qm74	5939	15	significantly	significantly	RB
cord-015021-pol2qm74	5939	16	elevated	elevate	VBN
cord-015021-pol2qm74	5939	17	(	(	-LRB-
cord-015021-pol2qm74	5939	18	p<0.05	p<0.05	CD
cord-015021-pol2qm74	5939	19	)	)	-RRB-
cord-015021-pol2qm74	5939	20	and	and	CC
cord-015021-pol2qm74	5939	21	correlated	correlate	VBN
cord-015021-pol2qm74	5939	22	well	well	RB
cord-015021-pol2qm74	5939	23	with	with	IN
cord-015021-pol2qm74	5939	24	severity	severity	NN
cord-015021-pol2qm74	5939	25	of	of	IN
cord-015021-pol2qm74	5939	26	disease	disease	NN
cord-015021-pol2qm74	5939	27	(	(	-LRB-
cord-015021-pol2qm74	5939	28	F0.597	F0.597	NNP
cord-015021-pol2qm74	5939	29	)	)	-RRB-
cord-015021-pol2qm74	5939	30	.	.	.
cord-015021-pol2qm74	5940	1	NO	no	DT
cord-015021-pol2qm74	5940	2	significant	significant	JJ
cord-015021-pol2qm74	5940	3	change	change	NN
cord-015021-pol2qm74	5940	4	in	in	IN
cord-015021-pol2qm74	5940	5	surface	surface	NN
cord-015021-pol2qm74	5940	6	expression	expression	NN
cord-015021-pol2qm74	5940	7	ofthrombospondin	ofthrombospondin	NNP
cord-015021-pol2qm74	5940	8	,	,	,
cord-015021-pol2qm74	5940	9	GMP-140	GMP-140	NNP
cord-015021-pol2qm74	5940	10	or	or	CC
cord-015021-pol2qm74	5940	11	GP53	GP53	NNP
cord-015021-pol2qm74	5940	12	was	be	VBD
cord-015021-pol2qm74	5940	13	noted	note	VBN
cord-015021-pol2qm74	5940	14	in	in	IN
cord-015021-pol2qm74	5940	15	septic	septic	JJ
cord-015021-pol2qm74	5940	16	patients	patient	NNS
cord-015021-pol2qm74	5940	17	.	.	.
cord-015021-pol2qm74	5941	1	In	in	IN
cord-015021-pol2qm74	5941	2	contrast	contrast	NN
cord-015021-pol2qm74	5941	3	,	,	,
cord-015021-pol2qm74	5941	4	degranulation	degranulation	NN
cord-015021-pol2qm74	5941	5	ofgraanle	ofgraanle	NNS
cord-015021-pol2qm74	5941	6	glycoproteins	glycoprotein	NNS
cord-015021-pol2qm74	5941	7	was	be	VBD
cord-015021-pol2qm74	5941	8	significantly	significantly	RB
cord-015021-pol2qm74	5941	9	elevated	elevate	VBN
cord-015021-pol2qm74	5941	10	in	in	IN
cord-015021-pol2qm74	5941	11	MOF	MOF	NNP
cord-015021-pol2qm74	5941	12	(	(	-LRB-
cord-015021-pol2qm74	5941	13	!	!	.
cord-015021-pol2qm74	5942	1	0<0.05	0<0.05	LS
cord-015021-pol2qm74	5942	2	)	)	-RRB-
cord-015021-pol2qm74	5942	3	that	that	WDT
cord-015021-pol2qm74	5942	4	correlated	correlate	VBD
cord-015021-pol2qm74	5942	5	well	well	RB
cord-015021-pol2qm74	5942	6	with	with	IN
cord-015021-pol2qm74	5942	7	severity	severity	NN
cord-015021-pol2qm74	5942	8	of	of	IN
cord-015021-pol2qm74	5942	9	MOF	MOF	NNP
cord-015021-pol2qm74	5942	10	(	(	-LRB-
cord-015021-pol2qm74	5942	11	GMP-140	gmp-140	XX
cord-015021-pol2qm74	5942	12	,	,	,
cord-015021-pol2qm74	5942	13	r=0.611	r=0.611	JJ
cord-015021-pol2qm74	5942	14	;	;	:
cord-015021-pol2qm74	5942	15	Thrombospondin	Thrombospondin	NNP
cord-015021-pol2qm74	5942	16	,	,	,
cord-015021-pol2qm74	5942	17	r=0.643).We	r=0.643).We	NNP
cord-015021-pol2qm74	5942	18	speculate	speculate	VBP
cord-015021-pol2qm74	5942	19	,	,	,
cord-015021-pol2qm74	5942	20	that	that	IN
cord-015021-pol2qm74	5942	21	platelets	platelet	NNS
cord-015021-pol2qm74	5942	22	in	in	IN
cord-015021-pol2qm74	5942	23	sepsis	sepsis	NN
cord-015021-pol2qm74	5942	24	circulate	circulate	VBP
cord-015021-pol2qm74	5942	25	in	in	IN
cord-015021-pol2qm74	5942	26	a	a	DT
cord-015021-pol2qm74	5942	27	hyperaggregable	hyperaggregable	NN
cord-015021-pol2qm74	5942	28	(	(	-LRB-
cord-015021-pol2qm74	5942	29	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	5942	30	receptor	receptor	NN
cord-015021-pol2qm74	5942	31	activation	activation	NN
cord-015021-pol2qm74	5942	32	)	)	-RRB-
cord-015021-pol2qm74	5942	33	but	but	CC
cord-015021-pol2qm74	5942	34	still	still	RB
cord-015021-pol2qm74	5942	35	reversible	reversible	JJ
cord-015021-pol2qm74	5942	36	state	state	NN
cord-015021-pol2qm74	5942	37	that	that	WDT
cord-015021-pol2qm74	5942	38	results	result	VBZ
cord-015021-pol2qm74	5942	39	in	in	IN
cord-015021-pol2qm74	5942	40	increased	increase	VBN
cord-015021-pol2qm74	5942	41	risk	risk	NN
cord-015021-pol2qm74	5942	42	of	of	IN
cord-015021-pol2qm74	5942	43	microthrombotic	microthrombotic	JJ
cord-015021-pol2qm74	5942	44	events	event	NNS
cord-015021-pol2qm74	5942	45	.	.	.
cord-015021-pol2qm74	5943	1	In	in	IN
cord-015021-pol2qm74	5943	2	the	the	DT
cord-015021-pol2qm74	5943	3	course	course	NN
cord-015021-pol2qm74	5943	4	of	of	IN
cord-015021-pol2qm74	5943	5	the	the	DT
cord-015021-pol2qm74	5943	6	disease	disease	NN
cord-015021-pol2qm74	5943	7	,	,	,
cord-015021-pol2qm74	5943	8	irreversible	irreversible	JJ
cord-015021-pol2qm74	5943	9	platelet	platelet	NN
cord-015021-pol2qm74	5943	10	degranulation	degranulation	NN
cord-015021-pol2qm74	5943	11	might	may	MD
cord-015021-pol2qm74	5943	12	occur	occur	VB
cord-015021-pol2qm74	5943	13	and	and	CC
cord-015021-pol2qm74	5943	14	may	may	MD
cord-015021-pol2qm74	5943	15	play	play	VB
cord-015021-pol2qm74	5943	16	an	an	DT
cord-015021-pol2qm74	5943	17	important	important	JJ
cord-015021-pol2qm74	5943	18	role	role	NN
cord-015021-pol2qm74	5943	19	in	in	IN
cord-015021-pol2qm74	5943	20	development	development	NN
cord-015021-pol2qm74	5943	21	of	of	IN
cord-015021-pol2qm74	5943	22	MOF	MOF	NNP
cord-015021-pol2qm74	5943	23	.	.	.
cord-015021-pol2qm74	5944	1	Abdominal	abdominal	JJ
cord-015021-pol2qm74	5944	2	sepsis	sepsis	NN
cord-015021-pol2qm74	5944	3	is	be	VBZ
cord-015021-pol2qm74	5944	4	still	still	RB
cord-015021-pol2qm74	5944	5	associated	associate	VBN
cord-015021-pol2qm74	5944	6	with	with	IN
cord-015021-pol2qm74	5944	7	high	high	JJ
cord-015021-pol2qm74	5944	8	morbidity	morbidity	NN
cord-015021-pol2qm74	5944	9	and	and	CC
cord-015021-pol2qm74	5944	10	mortality	mortality	NN
cord-015021-pol2qm74	5944	11	.	.	.
cord-015021-pol2qm74	5945	1	The	the	DT
cord-015021-pol2qm74	5945	2	present	present	JJ
cord-015021-pol2qm74	5945	3	study	study	NN
cord-015021-pol2qm74	5945	4	aimed	aim	VBN
cord-015021-pol2qm74	5945	5	at	at	IN
cord-015021-pol2qm74	5945	6	evaluating	evaluate	VBG
cord-015021-pol2qm74	5945	7	patients	patient	NNS
cord-015021-pol2qm74	5945	8	with	with	IN
cord-015021-pol2qm74	5945	9	abdominal	abdominal	JJ
cord-015021-pol2qm74	5945	10	sepsis	sepsis	NN
cord-015021-pol2qm74	5945	11	treated	treat	VBN
cord-015021-pol2qm74	5945	12	at	at	IN
cord-015021-pol2qm74	5945	13	our	-PRON-	PRP$
cord-015021-pol2qm74	5945	14	surgical	surgical	JJ
cord-015021-pol2qm74	5945	15	intensive	intensive	JJ
cord-015021-pol2qm74	5945	16	care	care	NN
cord-015021-pol2qm74	5945	17	unit	unit	NN
cord-015021-pol2qm74	5945	18	during	during	IN
cord-015021-pol2qm74	5945	19	a	a	DT
cord-015021-pol2qm74	5945	20	10-year	10-year	CD
cord-015021-pol2qm74	5945	21	period	period	NN
cord-015021-pol2qm74	5945	22	with	with	IN
cord-015021-pol2qm74	5945	23	the	the	DT
cord-015021-pol2qm74	5945	24	aim	aim	NN
cord-015021-pol2qm74	5945	25	of	of	IN
cord-015021-pol2qm74	5945	26	identifying	identify	VBG
cord-015021-pol2qm74	5945	27	potential	potential	JJ
cord-015021-pol2qm74	5945	28	prognostic	prognostic	JJ
cord-015021-pol2qm74	5945	29	factors	factor	NNS
cord-015021-pol2qm74	5945	30	,	,	,
cord-015021-pol2qm74	5945	31	bacteriological	bacteriological	JJ
cord-015021-pol2qm74	5945	32	cultures	culture	NNS
cord-015021-pol2qm74	5945	33	,	,	,
cord-015021-pol2qm74	5945	34	diagnostic	diagnostic	JJ
cord-015021-pol2qm74	5945	35	procedures	procedure	NNS
cord-015021-pol2qm74	5945	36	,	,	,
cord-015021-pol2qm74	5945	37	treatment	treatment	NN
cord-015021-pol2qm74	5945	38	and	and	CC
cord-015021-pol2qm74	5945	39	outcome	outcome	NN
cord-015021-pol2qm74	5945	40	.	.	.
cord-015021-pol2qm74	5946	1	During	during	IN
cord-015021-pol2qm74	5946	2	the	the	DT
cord-015021-pol2qm74	5946	3	period	period	NN
cord-015021-pol2qm74	5946	4	1983	1983	CD
cord-015021-pol2qm74	5946	5	-	-	SYM
cord-015021-pol2qm74	5946	6	1992	1992	CD
cord-015021-pol2qm74	5946	7	I66	I66	NNP
cord-015021-pol2qm74	5946	8	patients	patient	NNS
cord-015021-pol2qm74	5946	9	with	with	IN
cord-015021-pol2qm74	5946	10	abdominal	abdominal	JJ
cord-015021-pol2qm74	5946	11	sepsis	sepsis	NN
cord-015021-pol2qm74	5946	12	were	be	VBD
cord-015021-pol2qm74	5946	13	treated	treat	VBN
cord-015021-pol2qm74	5946	14	at	at	IN
cord-015021-pol2qm74	5946	15	the	the	DT
cord-015021-pol2qm74	5946	16	ICU	ICU	NNP
cord-015021-pol2qm74	5946	17	at	at	IN
cord-015021-pol2qm74	5946	18	our	-PRON-	PRP$
cord-015021-pol2qm74	5946	19	university	university	NN
cord-015021-pol2qm74	5946	20	hospital	hospital	NN
cord-015021-pol2qm74	5946	21	.	.	.
cord-015021-pol2qm74	5947	1	60	60	CD
cord-015021-pol2qm74	5947	2	patients	patient	NNS
cord-015021-pol2qm74	5947	3	were	be	VBD
cord-015021-pol2qm74	5947	4	women	woman	NNS
cord-015021-pol2qm74	5947	5	and	and	CC
cord-015021-pol2qm74	5947	6	106	106	CD
cord-015021-pol2qm74	5947	7	men	man	NNS
cord-015021-pol2qm74	5947	8	with	with	IN
cord-015021-pol2qm74	5947	9	a	a	DT
cord-015021-pol2qm74	5947	10	mean	mean	JJ
cord-015021-pol2qm74	5947	11	age	age	NN
cord-015021-pol2qm74	5947	12	of	of	IN
cord-015021-pol2qm74	5947	13	64	64	CD
cord-015021-pol2qm74	5947	14	(	(	-LRB-
cord-015021-pol2qm74	5947	15	17	17	CD
cord-015021-pol2qm74	5947	16	-	-	SYM
cord-015021-pol2qm74	5947	17	101	101	CD
cord-015021-pol2qm74	5947	18	)	)	-RRB-
cord-015021-pol2qm74	5947	19	years	year	NNS
cord-015021-pol2qm74	5947	20	.	.	.
cord-015021-pol2qm74	5948	1	In	in	IN
cord-015021-pol2qm74	5948	2	74	74	CD
cord-015021-pol2qm74	5948	3	cases	case	NNS
cord-015021-pol2qm74	5948	4	,	,	,
cord-015021-pol2qm74	5948	5	the	the	DT
cord-015021-pol2qm74	5948	6	abdominal	abdominal	JJ
cord-015021-pol2qm74	5948	7	sepsis	sepsis	NN
cord-015021-pol2qm74	5948	8	occurred	occur	VBD
cord-015021-pol2qm74	5948	9	as	as	IN
cord-015021-pol2qm74	5948	10	a	a	DT
cord-015021-pol2qm74	5948	11	postoperative	postoperative	JJ
cord-015021-pol2qm74	5948	12	complication	complication	NN
cord-015021-pol2qm74	5948	13	.	.	.
cord-015021-pol2qm74	5949	1	The	the	DT
cord-015021-pol2qm74	5949	2	patients	patient	NNS
cord-015021-pol2qm74	5949	3	were	be	VBD
cord-015021-pol2qm74	5949	4	scored	score	VBN
cord-015021-pol2qm74	5949	5	according	accord	VBG
cord-015021-pol2qm74	5949	6	to	to	IN
cord-015021-pol2qm74	5949	7	APACHE	APACHE	NNP
cord-015021-pol2qm74	5949	8	II	II	NNP
cord-015021-pol2qm74	5949	9	and	and	CC
cord-015021-pol2qm74	5949	10	bacteriological	bacteriological	JJ
cord-015021-pol2qm74	5949	11	cultures	culture	NNS
cord-015021-pol2qm74	5949	12	and	and	CC
cord-015021-pol2qm74	5949	13	the	the	DT
cord-015021-pol2qm74	5949	14	occurrence	occurrence	NN
cord-015021-pol2qm74	5949	15	of	of	IN
cord-015021-pol2qm74	5949	16	organ	organ	NN
cord-015021-pol2qm74	5949	17	failure	failure	NN
cord-015021-pol2qm74	5949	18	were	be	VBD
cord-015021-pol2qm74	5949	19	noted	note	VBN
cord-015021-pol2qm74	5949	20	.	.	.
cord-015021-pol2qm74	5950	1	The	the	DT
cord-015021-pol2qm74	5950	2	patients	patient	NNS
cord-015021-pol2qm74	5950	3	were	be	VBD
cord-015021-pol2qm74	5950	4	hospitalized	hospitalize	VBN
cord-015021-pol2qm74	5950	5	in	in	IN
cord-015021-pol2qm74	5950	6	median	median	NN
cord-015021-pol2qm74	5950	7	for	for	IN
cord-015021-pol2qm74	5950	8	40	40	CD
cord-015021-pol2qm74	5950	9	(	(	-LRB-
cord-015021-pol2qm74	5950	10	-273	-273	NN
cord-015021-pol2qm74	5950	11	)	)	-RRB-
cord-015021-pol2qm74	5950	12	days	day	NNS
cord-015021-pol2qm74	5950	13	out	out	IN
cord-015021-pol2qm74	5950	14	of	of	IN
cord-015021-pol2qm74	5950	15	which	which	WDT
cord-015021-pol2qm74	5950	16	7	7	CD
cord-015021-pol2qm74	5950	17	(	(	-LRB-
cord-015021-pol2qm74	5950	18	-178	-178	RB
cord-015021-pol2qm74	5950	19	)	)	-RRB-
cord-015021-pol2qm74	5950	20	in	in	IN
cord-015021-pol2qm74	5950	21	the	the	DT
cord-015021-pol2qm74	5950	22	intensive	intensive	JJ
cord-015021-pol2qm74	5950	23	care	care	NN
cord-015021-pol2qm74	5950	24	unit	unit	NN
cord-015021-pol2qm74	5950	25	.	.	.
cord-015021-pol2qm74	5951	1	46	46	CD
cord-015021-pol2qm74	5951	2	out	out	IN
cord-015021-pol2qm74	5951	3	of	of	IN
cord-015021-pol2qm74	5951	4	166	166	CD
cord-015021-pol2qm74	5951	5	patients	patient	NNS
cord-015021-pol2qm74	5951	6	(	(	-LRB-
cord-015021-pol2qm74	5951	7	28	28	CD
cord-015021-pol2qm74	5951	8	%	%	NN
cord-015021-pol2qm74	5951	9	)	)	-RRB-
cord-015021-pol2qm74	5951	10	died	die	VBD
cord-015021-pol2qm74	5951	11	in	in	IN
cord-015021-pol2qm74	5951	12	median	median	NN
cord-015021-pol2qm74	5951	13	after	after	IN
cord-015021-pol2qm74	5951	14	18	18	CD
cord-015021-pol2qm74	5951	15	(	(	-LRB-
cord-015021-pol2qm74	5951	16	1	1	CD
cord-015021-pol2qm74	5951	17	-	-	SYM
cord-015021-pol2qm74	5951	18	194	194	CD
cord-015021-pol2qm74	5951	19	)	)	-RRB-
cord-015021-pol2qm74	5951	20	days	day	NNS
cord-015021-pol2qm74	5951	21	.	.	.
cord-015021-pol2qm74	5952	1	The	the	DT
cord-015021-pol2qm74	5952	2	primary	primary	JJ
cord-015021-pol2qm74	5952	3	cause	cause	NN
cord-015021-pol2qm74	5952	4	of	of	IN
cord-015021-pol2qm74	5952	5	mortality	mortality	NN
cord-015021-pol2qm74	5952	6	was	be	VBD
cord-015021-pol2qm74	5952	7	multiple	multiple	JJ
cord-015021-pol2qm74	5952	8	organ	organ	NN
cord-015021-pol2qm74	5952	9	failure	failure	NN
cord-015021-pol2qm74	5952	10	(	(	-LRB-
cord-015021-pol2qm74	5952	11	38/46	38/46	CD
cord-015021-pol2qm74	5952	12	;	;	:
cord-015021-pol2qm74	5952	13	83	83	CD
cord-015021-pol2qm74	5952	14	%	%	NN
cord-015021-pol2qm74	5952	15	)	)	-RRB-
cord-015021-pol2qm74	5952	16	.	.	.
cord-015021-pol2qm74	5953	1	APACHE	APACHE	NNP
cord-015021-pol2qm74	5953	2	II	II	NNP
cord-015021-pol2qm74	5953	3	scoring	scoring	NN
cord-015021-pol2qm74	5953	4	could	could	MD
cord-015021-pol2qm74	5953	5	not	not	RB
cord-015021-pol2qm74	5953	6	predict	predict	VB
cord-015021-pol2qm74	5953	7	a	a	DT
cord-015021-pol2qm74	5953	8	fatal	fatal	JJ
cord-015021-pol2qm74	5953	9	outcome	outcome	NN
cord-015021-pol2qm74	5953	10	.	.	.
cord-015021-pol2qm74	5954	1	Abdominal	abdominal	JJ
cord-015021-pol2qm74	5954	2	bacterial	bacterial	JJ
cord-015021-pol2qm74	5954	3	cultures	culture	NNS
cord-015021-pol2qm74	5954	4	were	be	VBD
cord-015021-pol2qm74	5954	5	dominated	dominate	VBN
cord-015021-pol2qm74	5954	6	by	by	IN
cord-015021-pol2qm74	5954	7	bacteria	bacteria	NNS
cord-015021-pol2qm74	5954	8	of	of	IN
cord-015021-pol2qm74	5954	9	enteric	enteric	JJ
cord-015021-pol2qm74	5954	10	origin	origin	NN
cord-015021-pol2qm74	5954	11	(	(	-LRB-
cord-015021-pol2qm74	5954	12	83	83	CD
cord-015021-pol2qm74	5954	13	%	%	NN
cord-015021-pol2qm74	5954	14	)	)	-RRB-
cord-015021-pol2qm74	5954	15	and	and	CC
cord-015021-pol2qm74	5954	16	in	in	IN
cord-015021-pol2qm74	5954	17	60	60	CD
cord-015021-pol2qm74	5954	18	%	%	NN
cord-015021-pol2qm74	5954	19	cultures	culture	NNS
cord-015021-pol2qm74	5954	20	grew	grow	VBD
cord-015021-pol2qm74	5954	21	multiple	multiple	JJ
cord-015021-pol2qm74	5954	22	bacteria	bacteria	NNS
cord-015021-pol2qm74	5954	23	.	.	.
cord-015021-pol2qm74	5955	1	134	134	CD
cord-015021-pol2qm74	5955	2	patients	patient	NNS
cord-015021-pol2qm74	5955	3	bad	bad	JJ
cord-015021-pol2qm74	5955	4	organ	organ	NN
cord-015021-pol2qm74	5955	5	failure	failure	NN
cord-015021-pol2qm74	5955	6	and	and	CC
cord-015021-pol2qm74	5955	7	64	64	CD
cord-015021-pol2qm74	5955	8	multiple	multiple	JJ
cord-015021-pol2qm74	5955	9	organ	organ	NN
cord-015021-pol2qm74	5955	10	failure	failure	NN
cord-015021-pol2qm74	5955	11	.	.	.
cord-015021-pol2qm74	5956	1	29/166	29/166	CD
cord-015021-pol2qm74	5956	2	patients	patient	NNS
cord-015021-pol2qm74	5956	3	(	(	-LRB-
cord-015021-pol2qm74	5956	4	17	17	CD
cord-015021-pol2qm74	5956	5	%	%	NN
cord-015021-pol2qm74	5956	6	)	)	-RRB-
cord-015021-pol2qm74	5956	7	had	have	VBD
cord-015021-pol2qm74	5956	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	5956	9	sepsis	sepsis	NN
cord-015021-pol2qm74	5956	10	due	due	IN
cord-015021-pol2qm74	5956	11	to	to	IN
cord-015021-pol2qm74	5956	12	diffuse	diffuse	VB
cord-015021-pol2qm74	5956	13	peritonitis	peritonitis	NN
cord-015021-pol2qm74	5956	14	despite	despite	IN
cord-015021-pol2qm74	5956	15	a	a	DT
cord-015021-pol2qm74	5956	16	morphologically	morphologically	RB
cord-015021-pol2qm74	5956	17	intact	intact	JJ
cord-015021-pol2qm74	5956	18	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	5956	19	tract	tract	NN
cord-015021-pol2qm74	5956	20	and	and	CC
cord-015021-pol2qm74	5956	21	the	the	DT
cord-015021-pol2qm74	5956	22	absence	absence	NN
cord-015021-pol2qm74	5956	23	of	of	IN
cord-015021-pol2qm74	5956	24	localized	localized	JJ
cord-015021-pol2qm74	5956	25	abscess	abscess	NN
cord-015021-pol2qm74	5956	26	formation	formation	NN
cord-015021-pol2qm74	5956	27	.	.	.
cord-015021-pol2qm74	5957	1	Mortality	mortality	NN
cord-015021-pol2qm74	5957	2	in	in	IN
cord-015021-pol2qm74	5957	3	this	this	DT
cord-015021-pol2qm74	5957	4	group	group	NN
cord-015021-pol2qm74	5957	5	was	be	VBD
cord-015021-pol2qm74	5957	6	significantly	significantly	RB
cord-015021-pol2qm74	5957	7	higher	high	JJR
cord-015021-pol2qm74	5957	8	as	as	IN
cord-015021-pol2qm74	5957	9	was	be	VBD
cord-015021-pol2qm74	5957	10	the	the	DT
cord-015021-pol2qm74	5957	11	percentage	percentage	NN
cord-015021-pol2qm74	5957	12	of	of	IN
cord-015021-pol2qm74	5957	13	positive	positive	JJ
cord-015021-pol2qm74	5957	14	blood	blood	NN
cord-015021-pol2qm74	5957	15	cultures	culture	NNS
cord-015021-pol2qm74	5957	16	and	and	CC
cord-015021-pol2qm74	5957	17	the	the	DT
cord-015021-pol2qm74	5957	18	occurrence	occurrence	NN
cord-015021-pol2qm74	5957	19	of	of	IN
cord-015021-pol2qm74	5957	20	multiple	multiple	JJ
cord-015021-pol2qm74	5957	21	organ	organ	NN
cord-015021-pol2qm74	5957	22	failure	failure	NN
cord-015021-pol2qm74	5957	23	.	.	.
cord-015021-pol2qm74	5958	1	Abdominal	abdominal	JJ
cord-015021-pol2qm74	5958	2	sepsis	sepsis	NN
cord-015021-pol2qm74	5958	3	is	be	VBZ
cord-015021-pol2qm74	5958	4	still	still	RB
cord-015021-pol2qm74	5958	5	associated	associate	VBN
cord-015021-pol2qm74	5958	6	with	with	IN
cord-015021-pol2qm74	5958	7	a	a	DT
cord-015021-pol2qm74	5958	8	high	high	JJ
cord-015021-pol2qm74	5958	9	mortality	mortality	NN
cord-015021-pol2qm74	5958	10	,	,	,
cord-015021-pol2qm74	5958	11	predominantly	predominantly	RB
cord-015021-pol2qm74	5958	12	caused	cause	VBN
cord-015021-pol2qm74	5958	13	by	by	IN
cord-015021-pol2qm74	5958	14	multiple	multiple	JJ
cord-015021-pol2qm74	5958	15	organ	organ	NN
cord-015021-pol2qm74	5958	16	failure	failure	NN
cord-015021-pol2qm74	5958	17	.	.	.
cord-015021-pol2qm74	5959	1	Abdominal	abdominal	JJ
cord-015021-pol2qm74	5959	2	culture	culture	NN
cord-015021-pol2qm74	5959	3	findings	finding	NNS
cord-015021-pol2qm74	5959	4	are	be	VBP
cord-015021-pol2qm74	5959	5	dominated	dominate	VBN
cord-015021-pol2qm74	5959	6	by	by	IN
cord-015021-pol2qm74	5959	7	bacteria	bacteria	NNS
cord-015021-pol2qm74	5959	8	of	of	IN
cord-015021-pol2qm74	5959	9	enteric	enteric	JJ
cord-015021-pol2qm74	5959	10	origin	origin	NN
cord-015021-pol2qm74	5959	11	.	.	.
cord-015021-pol2qm74	5960	1	In	in	IN
cord-015021-pol2qm74	5960	2	about	about	IN
cord-015021-pol2qm74	5960	3	1/5	1/5	CD
cord-015021-pol2qm74	5960	4	of	of	IN
cord-015021-pol2qm74	5960	5	patients	patient	NNS
cord-015021-pol2qm74	5960	6	with	with	IN
cord-015021-pol2qm74	5960	7	severe	severe	JJ
cord-015021-pol2qm74	5960	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	5960	9	sepsis	sepsis	NN
cord-015021-pol2qm74	5960	10	a	a	DT
cord-015021-pol2qm74	5960	11	diffuse	diffuse	JJ
cord-015021-pol2qm74	5960	12	peritonitis	peritonitis	NN
cord-015021-pol2qm74	5960	13	with	with	IN
cord-015021-pol2qm74	5960	14	intact	intact	JJ
cord-015021-pol2qm74	5960	15	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	5960	16	tract	tract	NN
cord-015021-pol2qm74	5960	17	without	without	IN
cord-015021-pol2qm74	5960	18	localized	localized	JJ
cord-015021-pol2qm74	5960	19	abscess	abscess	NN
cord-015021-pol2qm74	5960	20	formation	formation	NN
cord-015021-pol2qm74	5960	21	was	be	VBD
cord-015021-pol2qm74	5960	22	found	find	VBN
cord-015021-pol2qm74	5960	23	.	.	.
cord-015021-pol2qm74	5961	1	In	in	IN
cord-015021-pol2qm74	5961	2	this	this	DT
cord-015021-pol2qm74	5961	3	group	group	NN
cord-015021-pol2qm74	5961	4	the	the	DT
cord-015021-pol2qm74	5961	5	mortality	mortality	NN
cord-015021-pol2qm74	5961	6	was	be	VBD
cord-015021-pol2qm74	5961	7	increased	increase	VBN
cord-015021-pol2qm74	5961	8	as	as	RB
cord-015021-pol2qm74	5961	9	well	well	RB
cord-015021-pol2qm74	5961	10	as	as	IN
cord-015021-pol2qm74	5961	11	the	the	DT
cord-015021-pol2qm74	5961	12	risk	risk	NN
cord-015021-pol2qm74	5961	13	of	of	IN
cord-015021-pol2qm74	5961	14	developing	develop	VBG
cord-015021-pol2qm74	5961	15	multiple	multiple	JJ
cord-015021-pol2qm74	5961	16	organ	organ	NN
cord-015021-pol2qm74	5961	17	failure	failure	NN
cord-015021-pol2qm74	5961	18	.	.	.
cord-015021-pol2qm74	5962	1	During	during	IN
cord-015021-pol2qm74	5962	2	the	the	DT
cord-015021-pol2qm74	5962	3	period	period	NN
cord-015021-pol2qm74	5962	4	from	from	IN
cord-015021-pol2qm74	5962	5	January	January	NNP
cord-015021-pol2qm74	5962	6	1985	1985	CD
cord-015021-pol2qm74	5962	7	to	to	IN
cord-015021-pol2qm74	5962	8	September	September	NNP
cord-015021-pol2qm74	5962	9	1993	1993	CD
cord-015021-pol2qm74	5962	10	56	56	CD
cord-015021-pol2qm74	5962	11	patients	patient	NNS
cord-015021-pol2qm74	5962	12	,	,	,
cord-015021-pol2qm74	5962	13	mean	mean	VB
cord-015021-pol2qm74	5962	14	age	age	NN
cord-015021-pol2qm74	5962	15	24	24	CD
cord-015021-pol2qm74	5962	16	+	+	SYM
cord-015021-pol2qm74	5962	17	4	4	CD
cord-015021-pol2qm74	5962	18	years	year	NNS
cord-015021-pol2qm74	5962	19	were	be	VBD
cord-015021-pol2qm74	5962	20	referred	refer	VBN
cord-015021-pol2qm74	5962	21	to	to	IN
cord-015021-pol2qm74	5962	22	our	-PRON-	PRP$
cord-015021-pol2qm74	5962	23	department	department	NN
cord-015021-pol2qm74	5962	24	of	of	IN
cord-015021-pol2qm74	5962	25	Resuscitologywith	Resuscitologywith	NNP
cord-015021-pol2qm74	5962	26	the	the	DT
cord-015021-pol2qm74	5962	27	diagnosis	diagnosis	NN
cord-015021-pol2qm74	5962	28	of	of	IN
cord-015021-pol2qm74	5962	29	eclampsia	eclampsia	NN
cord-015021-pol2qm74	5962	30	.	.	.
cord-015021-pol2qm74	5963	1	All	all	PDT
cord-015021-pol2qm74	5963	2	the	the	DT
cord-015021-pol2qm74	5963	3	patients	patient	NNS
cord-015021-pol2qm74	5963	4	were	be	VBD
cord-015021-pol2qm74	5963	5	delivered	deliver	VBN
cord-015021-pol2qm74	5963	6	by	by	IN
cord-015021-pol2qm74	5963	7	cesarian	cesarian	NN
cord-015021-pol2qm74	5963	8	section	section	NN
cord-015021-pol2qm74	5963	9	and	and	CC
cord-015021-pol2qm74	5963	10	were	be	VBD
cord-015021-pol2qm74	5963	11	mechanically	mechanically	RB
cord-015021-pol2qm74	5963	12	ventilated	ventilate	VBN
cord-015021-pol2qm74	5963	13	for	for	IN
cord-015021-pol2qm74	5963	14	7.3_+5.7	7.3_+5.7	CD
cord-015021-pol2qm74	5963	15	days	day	NNS
cord-015021-pol2qm74	5963	16	.	.	.
cord-015021-pol2qm74	5964	1	Diagnosis	diagnosis	NN
cord-015021-pol2qm74	5964	2	of	of	IN
cord-015021-pol2qm74	5964	3	sepsis	sepsis	NN
cord-015021-pol2qm74	5964	4	was	be	VBD
cord-015021-pol2qm74	5964	5	confirmed	confirm	VBN
cord-015021-pol2qm74	5964	6	in	in	IN
cord-015021-pol2qm74	5964	7	6	6	CD
cord-015021-pol2qm74	5964	8	cases	case	NNS
cord-015021-pol2qm74	5964	9	by	by	IN
cord-015021-pol2qm74	5964	10	clinical	clinical	JJ
cord-015021-pol2qm74	5964	11	and	and	CC
cord-015021-pol2qm74	5964	12	microbiological	microbiological	JJ
cord-015021-pol2qm74	5964	13	methods	method	NNS
cord-015021-pol2qm74	5964	14	.	.	.
cord-015021-pol2qm74	5965	1	Patients	patient	NNS
cord-015021-pol2qm74	5965	2	were	be	VBD
cord-015021-pol2qm74	5965	3	divided	divide	VBN
cord-015021-pol2qm74	5965	4	in	in	IN
cord-015021-pol2qm74	5965	5	two	two	CD
cord-015021-pol2qm74	5965	6	groups	group	NNS
cord-015021-pol2qm74	5965	7	:	:	:
cord-015021-pol2qm74	5965	8	lnon	lnon	NN
cord-015021-pol2qm74	5965	9	septic	septic	JJ
cord-015021-pol2qm74	5965	10	patients	patient	NNS
cord-015021-pol2qm74	5965	11	,	,	,
cord-015021-pol2qm74	5965	12	2-patients	2-patients	CD
cord-015021-pol2qm74	5965	13	with	with	IN
cord-015021-pol2qm74	5965	14	sepsis	sepsis	NN
cord-015021-pol2qm74	5965	15	,	,	,
cord-015021-pol2qm74	5965	16	the	the	DT
cord-015021-pol2qm74	5965	17	control	control	NN
cord-015021-pol2qm74	5965	18	group	group	NN
cord-015021-pol2qm74	5965	19	consisted	consist	VBD
cord-015021-pol2qm74	5965	20	of	of	IN
cord-015021-pol2qm74	5965	21	20	20	CD
cord-015021-pol2qm74	5965	22	patients	patient	NNS
cord-015021-pol2qm74	5965	23	after	after	IN
cord-015021-pol2qm74	5965	24	cesarian	cesarian	NN
cord-015021-pol2qm74	5965	25	section	section	NN
cord-015021-pol2qm74	5965	26	without	without	IN
cord-015021-pol2qm74	5965	27	symptoms	symptom	NNS
cord-015021-pol2qm74	5965	28	of	of	IN
cord-015021-pol2qm74	5965	29	eclampsia	eclampsia	NN
cord-015021-pol2qm74	5965	30	or	or	CC
cord-015021-pol2qm74	5965	31	infection	infection	NN
cord-015021-pol2qm74	5965	32	.	.	.
cord-015021-pol2qm74	5966	1	We	-PRON-	PRP
cord-015021-pol2qm74	5966	2	determined	determine	VBD
cord-015021-pol2qm74	5966	3	plasma	plasma	NN
cord-015021-pol2qm74	5966	4	concentrations	concentration	NNS
cord-015021-pol2qm74	5966	5	of	of	IN
cord-015021-pol2qm74	5966	6	immunoglobulins	immunoglobulin	NNS
cord-015021-pol2qm74	5966	7	A	A	NNP
cord-015021-pol2qm74	5966	8	,	,	,
cord-015021-pol2qm74	5966	9	G	G	NNP
cord-015021-pol2qm74	5966	10	,	,	,
cord-015021-pol2qm74	5966	11	M(A	M(A	NNP
cord-015021-pol2qm74	5966	12	,	,	,
cord-015021-pol2qm74	5966	13	G	G	NNP
cord-015021-pol2qm74	5966	14	,	,	,
cord-015021-pol2qm74	5966	15	M	M	NNP
cord-015021-pol2qm74	5966	16	)	)	-RRB-
cord-015021-pol2qm74	5966	17	,	,	,
cord-015021-pol2qm74	5966	18	complement	complement	NN
cord-015021-pol2qm74	5966	19	factors	factor	NNS
cord-015021-pol2qm74	5966	20	(	(	-LRB-
cord-015021-pol2qm74	5966	21	C3,C4	C3,C4	NNP
cord-015021-pol2qm74	5966	22	)	)	-RRB-
cord-015021-pol2qm74	5966	23	,	,	,
cord-015021-pol2qm74	5966	24	alphal	alphal	NN
cord-015021-pol2qm74	5966	25	-	-	HYPH
cord-015021-pol2qm74	5966	26	antitrypsin	antitrypsin	NN
cord-015021-pol2qm74	5966	27	(	(	-LRB-
cord-015021-pol2qm74	5966	28	AAT	AAT	NNP
cord-015021-pol2qm74	5966	29	)	)	-RRB-
cord-015021-pol2qm74	5966	30	,	,	,
cord-015021-pol2qm74	5966	31	trausferrin	trausferrin	NNP
cord-015021-pol2qm74	5966	32	(	(	-LRB-
cord-015021-pol2qm74	5966	33	TRF	TRF	NNP
cord-015021-pol2qm74	5966	34	)	)	-RRB-
cord-015021-pol2qm74	5966	35	and	and	CC
cord-015021-pol2qm74	5966	36	albumin	albumin	NN
cord-015021-pol2qm74	5966	37	(	(	-LRB-
cord-015021-pol2qm74	5966	38	ALB	ALB	NNP
cord-015021-pol2qm74	5966	39	)	)	-RRB-
cord-015021-pol2qm74	5966	40	using	use	VBG
cord-015021-pol2qm74	5966	41	BECKMAN	BECKMAN	NNP
cord-015021-pol2qm74	5966	42	(	(	-LRB-
cord-015021-pol2qm74	5966	43	USA	USA	NNP
cord-015021-pol2qm74	5966	44	)	)	-RRB-
cord-015021-pol2qm74	5966	45	analyzer	analyzer	NN
cord-015021-pol2qm74	5966	46	,	,	,
cord-015021-pol2qm74	5966	47	protein	protein	NN
cord-015021-pol2qm74	5966	48	concentration	concentration	NN
cord-015021-pol2qm74	5966	49	,	,	,
cord-015021-pol2qm74	5966	50	using	use	VBG
cord-015021-pol2qm74	5966	51	KONE	KONE	NNP
cord-015021-pol2qm74	5966	52	(	(	-LRB-
cord-015021-pol2qm74	5966	53	Finland	Finland	NNP
cord-015021-pol2qm74	5966	54	)	)	-RRB-
cord-015021-pol2qm74	5966	55	analyzer	analyzer	NN
cord-015021-pol2qm74	5966	56	.	.	.
cord-015021-pol2qm74	5967	1	A(mg	A(mg	NNP
cord-015021-pol2qm74	5968	1	/dL	/dL	NFP
cord-015021-pol2qm74	5968	2	)	)	-RRB-
cord-015021-pol2qm74	5969	1	G(mg	G(mg	NNP
cord-015021-pol2qm74	5969	2	/	/	SYM
cord-015021-pol2qm74	5969	3	dL	dl	NN
cord-015021-pol2qm74	5969	4	)	)	-RRB-
cord-015021-pol2qm74	5970	1	M(mg	M(mg	NNP
cord-015021-pol2qm74	5970	2	/	/	SYM
cord-015021-pol2qm74	5970	3	dL	dl	NN
cord-015021-pol2qm74	5970	4	)	)	-RRB-
cord-015021-pol2qm74	5971	1	C3(mg	c3(mg	NN
cord-015021-pol2qm74	5971	2	/	/	SYM
cord-015021-pol2qm74	5971	3	dL	dl	NN
cord-015021-pol2qm74	5971	4	)	)	-RRB-
cord-015021-pol2qm74	5972	1	C4(mg	C4(mg	NNP
cord-015021-pol2qm74	5972	2	/	/	SYM
cord-015021-pol2qm74	5972	3	dL	dl	NN
cord-015021-pol2qm74	5972	4	)	)	-RRB-
cord-015021-pol2qm74	5973	1	K	K	NNP
cord-015021-pol2qm74	5973	2	203	203	CD
cord-015021-pol2qm74	5973	3	+	+	CC
cord-015021-pol2qm74	5973	4	-31	-31	CD
cord-015021-pol2qm74	5973	5	971	971	CD
cord-015021-pol2qm74	5973	6	+	+	SYM
cord-015021-pol2qm74	5973	7	47	47	CD
cord-015021-pol2qm74	5973	8	205_+21	205_+21	CD
cord-015021-pol2qm74	5974	1	134	134	CD
cord-015021-pol2qm74	5974	2	+	+	SYM
cord-015021-pol2qm74	5974	3	12	12	CD
cord-015021-pol2qm74	5974	4	30	30	CD
cord-015021-pol2qm74	5974	5	+	+	CD
cord-015021-pol2qm74	5975	1	-3	-3	NNP
cord-015021-pol2qm74	5975	2	1	1	CD
cord-015021-pol2qm74	5975	3	154-+29	154-+29	CD
cord-015021-pol2qm74	5975	4	"	"	``
cord-015021-pol2qm74	5975	5	568-+48	568-+48	NNP
cord-015021-pol2qm74	5975	6	*	*	NFP
cord-015021-pol2qm74	5975	7	142_+24	142_+24	CD
cord-015021-pol2qm74	5975	8	"	"	``
cord-015021-pol2qm74	5975	9	81-+14	81-+14	CD
cord-015021-pol2qm74	5975	10	'	'	CD
cord-015021-pol2qm74	5975	11	17_+4	17_+4	CD
cord-015021-pol2qm74	5975	12	"	"	''
cord-015021-pol2qm74	5975	13	2	2	CD
cord-015021-pol2qm74	5975	14	102+_21	102+_21	CD
cord-015021-pol2qm74	5975	15	'	'	POS
cord-015021-pol2qm74	5975	16	*	*	NFP
cord-015021-pol2qm74	5975	17	420-+30	420-+30	CD
cord-015021-pol2qm74	5975	18	*	*	NFP
cord-015021-pol2qm74	5975	19	*	*	NFP
cord-015021-pol2qm74	5975	20	96-+21	96-+21	CD
cord-015021-pol2qm74	5976	1	"	"	``
cord-015021-pol2qm74	5976	2	*	*	NFP
cord-015021-pol2qm74	5976	3	67-+10	67-+10	CD
cord-015021-pol2qm74	5976	4	"	"	''
cord-015021-pol2qm74	5977	1	*	*	NFP
cord-015021-pol2qm74	5977	2	11_+3	11_+3	CD
cord-015021-pol2qm74	5977	3	"	"	``
cord-015021-pol2qm74	5977	4	In	in	IN
cord-015021-pol2qm74	5977	5	a	a	DT
cord-015021-pol2qm74	5977	6	prospective	prospective	JJ
cord-015021-pol2qm74	5977	7	study	study	NN
cord-015021-pol2qm74	5977	8	we	-PRON-	PRP
cord-015021-pol2qm74	5977	9	investigated	investigate	VBD
cord-015021-pol2qm74	5977	10	serum	serum	NN
cord-015021-pol2qm74	5977	11	of	of	IN
cord-015021-pol2qm74	5977	12	12	12	CD
cord-015021-pol2qm74	5977	13	severly	severly	RB
cord-015021-pol2qm74	5977	14	traumatized	traumatize	VBN
cord-015021-pol2qm74	5977	15	patients	patient	NNS
cord-015021-pol2qm74	5977	16	withdrawn	withdraw	VBN
cord-015021-pol2qm74	5977	17	directly	directly	RB
cord-015021-pol2qm74	5977	18	after	after	IN
cord-015021-pol2qm74	5977	19	admission	admission	NN
cord-015021-pol2qm74	5977	20	at	at	IN
cord-015021-pol2qm74	5977	21	our	-PRON-	PRP$
cord-015021-pol2qm74	5977	22	hospital	hospital	NN
cord-015021-pol2qm74	5977	23	(	(	-LRB-
cord-015021-pol2qm74	5977	24	TR	TR	NNP
cord-015021-pol2qm74	5977	25	I	I	NNP
cord-015021-pol2qm74	5977	26	)	)	-RRB-
cord-015021-pol2qm74	5977	27	.	.	.
cord-015021-pol2qm74	5978	1	Follow	follow	VB
cord-015021-pol2qm74	5978	2	up	up	RP
cord-015021-pol2qm74	5978	3	controls	control	NNS
cord-015021-pol2qm74	5978	4	were	be	VBD
cord-015021-pol2qm74	5978	5	taken	take	VBN
cord-015021-pol2qm74	5978	6	daily	daily	RB
cord-015021-pol2qm74	5978	7	until	until	IN
cord-015021-pol2qm74	5978	8	day	day	NN
cord-015021-pol2qm74	5978	9	ten	ten	CD
cord-015021-pol2qm74	5978	10	after	after	IN
cord-015021-pol2qm74	5978	11	trauma	trauma	NN
cord-015021-pol2qm74	5978	12	(	(	-LRB-
cord-015021-pol2qm74	5978	13	TR	TR	NNP
cord-015021-pol2qm74	5978	14	II	II	NNP
cord-015021-pol2qm74	5978	15	)	)	-RRB-
cord-015021-pol2qm74	5978	16	.	.	.
cord-015021-pol2qm74	5979	1	Two	two	CD
cord-015021-pol2qm74	5979	2	control	control	NN
cord-015021-pol2qm74	5979	3	groups	group	NNS
cord-015021-pol2qm74	5979	4	were	be	VBD
cord-015021-pol2qm74	5979	5	performed	perform	VBN
cord-015021-pol2qm74	5979	6	:	:	:
cord-015021-pol2qm74	5979	7	Serum	serum	NN
cord-015021-pol2qm74	5979	8	of	of	IN
cord-015021-pol2qm74	5979	9	healthy	healthy	JJ
cord-015021-pol2qm74	5979	10	volunteers	volunteer	NNS
cord-015021-pol2qm74	5979	11	(	(	-LRB-
cord-015021-pol2qm74	5979	12	CO	CO	NNP
cord-015021-pol2qm74	5979	13	,	,	,
cord-015021-pol2qm74	5979	14	n	n	NN
cord-015021-pol2qm74	5979	15	=	=	SYM
cord-015021-pol2qm74	5979	16	24	24	CD
cord-015021-pol2qm74	5979	17	)	)	-RRB-
cord-015021-pol2qm74	5979	18	was	be	VBD
cord-015021-pol2qm74	5979	19	investigated	investigate	VBN
cord-015021-pol2qm74	5979	20	as	as	IN
cord-015021-pol2qm74	5979	21	.	.	.
cord-015021-pol2qm74	5980	1	well	well	UH
cord-015021-pol2qm74	5980	2	as	as	IN
cord-015021-pol2qm74	5980	3	serum	serum	NN
cord-015021-pol2qm74	5980	4	of	of	IN
cord-015021-pol2qm74	5980	5	patients	patient	NNS
cord-015021-pol2qm74	5980	6	undergoing	undergo	VBG
cord-015021-pol2qm74	5980	7	elective	elective	JJ
cord-015021-pol2qm74	5980	8	herniotomy	herniotomy	NN
cord-015021-pol2qm74	5980	9	(	(	-LRB-
cord-015021-pol2qm74	5980	10	n=12	n=12	NNP
cord-015021-pol2qm74	5980	11	)	)	-RRB-
cord-015021-pol2qm74	5980	12	24	24	CD
cord-015021-pol2qm74	5980	13	hours	hour	NNS
cord-015021-pol2qm74	5980	14	before	before	IN
cord-015021-pol2qm74	5980	15	(	(	-LRB-
cord-015021-pol2qm74	5980	16	OP	OP	NNP
cord-015021-pol2qm74	5980	17	I	I	NNP
cord-015021-pol2qm74	5980	18	)	)	-RRB-
cord-015021-pol2qm74	5980	19	and	and	CC
cord-015021-pol2qm74	5980	20	24	24	CD
cord-015021-pol2qm74	5980	21	hours	hour	NNS
cord-015021-pol2qm74	5980	22	after	after	IN
cord-015021-pol2qm74	5980	23	operation	operation	NN
cord-015021-pol2qm74	5980	24	(	(	-LRB-
cord-015021-pol2qm74	5980	25	OP	OP	NNP
cord-015021-pol2qm74	5980	26	II	II	NNP
cord-015021-pol2qm74	5980	27	)	)	-RRB-
cord-015021-pol2qm74	5980	28	.	.	.
cord-015021-pol2qm74	5981	1	Serum	serum	NN
cord-015021-pol2qm74	5981	2	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	5981	3	index	index	NN
cord-015021-pol2qm74	5981	4	(	(	-LRB-
cord-015021-pol2qm74	5981	5	SBI	SBI	NNP
cord-015021-pol2qm74	5981	6	)	)	-RRB-
cord-015021-pol2qm74	5981	7	was	be	VBD
cord-015021-pol2qm74	5981	8	determined	determine	VBN
cord-015021-pol2qm74	5981	9	using	use	VBG
cord-015021-pol2qm74	5981	10	a	a	DT
cord-015021-pol2qm74	5981	11	hemolytic	hemolytic	JJ
cord-015021-pol2qm74	5981	12	E.coli	e.coli	NN
cord-015021-pol2qm74	5981	13	strain	strain	NN
cord-015021-pol2qm74	5981	14	08	08	CD
cord-015021-pol2qm74	5981	15	:	:	:
cord-015021-pol2qm74	5981	16	K87	k87	JJ
cord-015021-pol2qm74	5981	17	:	:	:
cord-015021-pol2qm74	5981	18	H19	H19	NNP
cord-015021-pol2qm74	5981	19	.	.	.
cord-015021-pol2qm74	5982	1	200/11	200/11	NNS
cord-015021-pol2qm74	5982	2	suspension	suspension	NN
cord-015021-pol2qm74	5982	3	with	with	IN
cord-015021-pol2qm74	5982	4	a	a	DT
cord-015021-pol2qm74	5982	5	final	final	JJ
cord-015021-pol2qm74	5982	6	concentration	concentration	NN
cord-015021-pol2qm74	5982	7	of	of	IN
cord-015021-pol2qm74	5982	8	250	250	CD
cord-015021-pol2qm74	5982	9	-400	-400	NN
cord-015021-pol2qm74	5982	10	CFU	CFU	NNP
cord-015021-pol2qm74	5982	11	were	be	VBD
cord-015021-pol2qm74	5982	12	incubated	incubate	VBN
cord-015021-pol2qm74	5982	13	with	with	IN
cord-015021-pol2qm74	5982	14	l	l	NNP
cord-015021-pol2qm74	5982	15	OOpl	OOpl	NNP
cord-015021-pol2qm74	5982	16	serum	serum	NN
cord-015021-pol2qm74	5982	17	.	.	.
cord-015021-pol2qm74	5983	1	After	after	IN
cord-015021-pol2qm74	5983	2	overnight	overnight	JJ
cord-015021-pol2qm74	5983	3	incubation	incubation	NN
cord-015021-pol2qm74	5983	4	SBI	SBI	NNP
cord-015021-pol2qm74	5983	5	was	be	VBD
cord-015021-pol2qm74	5983	6	calculated	calculate	VBN
cord-015021-pol2qm74	5983	7	according	accord	VBG
cord-015021-pol2qm74	5983	8	a	a	DT
cord-015021-pol2qm74	5983	9	special	special	JJ
cord-015021-pol2qm74	5983	10	formula	formula	NN
cord-015021-pol2qm74	5983	11	.	.	.
cord-015021-pol2qm74	5984	1	Results	result	NNS
cord-015021-pol2qm74	5984	2	:	:	:
cord-015021-pol2qm74	5984	3	CO	co	NN
cord-015021-pol2qm74	5985	1	74.8	74.8	CD
cord-015021-pol2qm74	5985	2	_	_	NN
cord-015021-pol2qm74	5985	3	+	+	SYM
cord-015021-pol2qm74	5985	4	6.3	6.3	CD
cord-015021-pol2qm74	5985	5	OPI	OPI	NNP
cord-015021-pol2qm74	5985	6	77.8	77.8	NNP
cord-015021-pol2qm74	5985	7	_	_	NNP
cord-015021-pol2qm74	5985	8	+	+	CC
cord-015021-pol2qm74	5985	9	6.4	6.4	CD
cord-015021-pol2qm74	5985	10	OPII	opii	JJ
cord-015021-pol2qm74	5985	11	68.2	68.2	CD
cord-015021-pol2qm74	5985	12	_	_	NN
cord-015021-pol2qm74	5986	1	+	+	CC
cord-015021-pol2qm74	5987	1	7.7	7.7	CD
cord-015021-pol2qm74	5987	2	*	*	NFP
cord-015021-pol2qm74	5987	3	TRI	tri	NN
cord-015021-pol2qm74	5988	1	38.4	38.4	CD
cord-015021-pol2qm74	5988	2	_	_	NN
cord-015021-pol2qm74	5988	3	+	+	SYM
cord-015021-pol2qm74	5988	4	9.1	9.1	CD
cord-015021-pol2qm74	5988	5	"	"	''
cord-015021-pol2qm74	5989	1	*	*	NFP
cord-015021-pol2qm74	5989	2	TRII	TRII	NNP
cord-015021-pol2qm74	5989	3	57.6	57.6	CD
cord-015021-pol2qm74	5989	4	+	+	SYM
cord-015021-pol2qm74	5989	5	8.9	8.9	CD
cord-015021-pol2qm74	5990	1	*	*	NFP
cord-015021-pol2qm74	5990	2	*	*	NFP
cord-015021-pol2qm74	5990	3	(	(	-LRB-
cord-015021-pol2qm74	5990	4	*	*	NFP
cord-015021-pol2qm74	5990	5	:p	:p	NFP
cord-015021-pol2qm74	5990	6	<	<	XX
cord-015021-pol2qm74	5990	7	0.05	0.05	CD
cord-015021-pol2qm74	5990	8	;	;	:
cord-015021-pol2qm74	5991	1	*	*	NFP
cord-015021-pol2qm74	5991	2	*	*	NFP
cord-015021-pol2qm74	5991	3	:p	:p	.
cord-015021-pol2qm74	5991	4	<	<	XX
cord-015021-pol2qm74	5992	1	O.01	o.01	CD
cord-015021-pol2qm74	5992	2	)	)	-RRB-
cord-015021-pol2qm74	5993	1	SBI	SBI	NNP
cord-015021-pol2qm74	5993	2	represents	represent	VBZ
cord-015021-pol2qm74	5993	3	a	a	DT
cord-015021-pol2qm74	5993	4	simple	simple	JJ
cord-015021-pol2qm74	5993	5	and	and	CC
cord-015021-pol2qm74	5993	6	reproducible	reproducible	JJ
cord-015021-pol2qm74	5993	7	method	method	NN
cord-015021-pol2qm74	5993	8	to	to	TO
cord-015021-pol2qm74	5993	9	detect	detect	VB
cord-015021-pol2qm74	5993	10	immunobiological	immunobiological	JJ
cord-015021-pol2qm74	5993	11	alterations	alteration	NNS
cord-015021-pol2qm74	5993	12	after	after	IN
cord-015021-pol2qm74	5993	13	trauma	trauma	NN
cord-015021-pol2qm74	5993	14	and	and	CC
cord-015021-pol2qm74	5993	15	elective	elective	JJ
cord-015021-pol2qm74	5993	16	surgery	surgery	NN
cord-015021-pol2qm74	5993	17	.	.	.
cord-015021-pol2qm74	5994	1	Patients	patient	NNS
cord-015021-pol2qm74	5994	2	undergoing	undergo	VBG
cord-015021-pol2qm74	5994	3	elective	elective	JJ
cord-015021-pol2qm74	5994	4	surgery	surgery	NN
cord-015021-pol2qm74	5994	5	showed	show	VBD
cord-015021-pol2qm74	5994	6	slight	slight	JJ
cord-015021-pol2qm74	5994	7	but	but	CC
cord-015021-pol2qm74	5994	8	significant	significant	JJ
cord-015021-pol2qm74	5994	9	diminuation	diminuation	NN
cord-015021-pol2qm74	5994	10	of	of	IN
cord-015021-pol2qm74	5994	11	SBI	SBI	NNP
cord-015021-pol2qm74	5994	12	24h	24h	NNS
cord-015021-pol2qm74	5994	13	after	after	IN
cord-015021-pol2qm74	5994	14	operation	operation	NN
cord-015021-pol2qm74	5994	15	.	.	.
cord-015021-pol2qm74	5995	1	Deterioration	deterioration	NN
cord-015021-pol2qm74	5995	2	of	of	IN
cord-015021-pol2qm74	5995	3	SBI	SBI	NNP
cord-015021-pol2qm74	5995	4	was	be	VBD
cord-015021-pol2qm74	5995	5	observed	observe	VBN
cord-015021-pol2qm74	5995	6	in	in	IN
cord-015021-pol2qm74	5995	7	serum	serum	NN
cord-015021-pol2qm74	5995	8	of	of	IN
cord-015021-pol2qm74	5995	9	traumatized	traumatize	VBN
cord-015021-pol2qm74	5995	10	patients	patient	NNS
cord-015021-pol2qm74	5995	11	directly	directly	RB
cord-015021-pol2qm74	5995	12	withdrawn	withdraw	VBN
cord-015021-pol2qm74	5995	13	after	after	IN
cord-015021-pol2qm74	5995	14	admission	admission	NN
cord-015021-pol2qm74	5995	15	at	at	IN
cord-015021-pol2qm74	5995	16	our	-PRON-	PRP$
cord-015021-pol2qm74	5995	17	hospital	hospital	NN
cord-015021-pol2qm74	5995	18	.	.	.
cord-015021-pol2qm74	5996	1	Ten	ten	CD
cord-015021-pol2qm74	5996	2	days	day	NNS
cord-015021-pol2qm74	5996	3	after	after	IN
cord-015021-pol2qm74	5996	4	trauma	trauma	NN
cord-015021-pol2qm74	5996	5	significant	significant	JJ
cord-015021-pol2qm74	5996	6	improvement	improvement	NN
cord-015021-pol2qm74	5996	7	of	of	IN
cord-015021-pol2qm74	5996	8	SBI	SBI	NNP
cord-015021-pol2qm74	5996	9	was	be	VBD
cord-015021-pol2qm74	5996	10	found	find	VBN
cord-015021-pol2qm74	5996	11	.	.	.
cord-015021-pol2qm74	5997	1	Further	further	JJ
cord-015021-pol2qm74	5997	2	investigations	investigation	NNS
cord-015021-pol2qm74	5997	3	have	have	VBP
cord-015021-pol2qm74	5997	4	to	to	TO
cord-015021-pol2qm74	5997	5	be	be	VB
cord-015021-pol2qm74	5997	6	done	do	VBN
cord-015021-pol2qm74	5997	7	to	to	IN
cord-015021-pol2qm74	5997	8	proof	proof	NN
cord-015021-pol2qm74	5997	9	sensitivity	sensitivity	NN
cord-015021-pol2qm74	5997	10	and	and	CC
cord-015021-pol2qm74	5997	11	prospectivity	prospectivity	NN
cord-015021-pol2qm74	5997	12	of	of	IN
cord-015021-pol2qm74	5997	13	this	this	DT
cord-015021-pol2qm74	5997	14	simple	simple	JJ
cord-015021-pol2qm74	5997	15	but	but	CC
cord-015021-pol2qm74	5997	16	reliable	reliable	JJ
cord-015021-pol2qm74	5997	17	test	test	NN
cord-015021-pol2qm74	5997	18	.	.	.
cord-015021-pol2qm74	5998	1	A	a	DT
cord-015021-pol2qm74	5998	2	sepsis	sepsis	NN
cord-015021-pol2qm74	5998	3	like	like	IN
cord-015021-pol2qm74	5998	4	syndrome	syndrome	NN
cord-015021-pol2qm74	5998	5	(	(	-LRB-
cord-015021-pol2qm74	5998	6	SLS	SLS	NNP
cord-015021-pol2qm74	5998	7	)	)	-RRB-
cord-015021-pol2qm74	5998	8	occurs	occur	VBZ
cord-015021-pol2qm74	5998	9	in	in	IN
cord-015021-pol2qm74	5998	10	i0	i0	NN
cord-015021-pol2qm74	5998	11	%	%	NN
cord-015021-pol2qm74	5998	12	of	of	IN
cord-015021-pol2qm74	5998	13	our	-PRON-	PRP$
cord-015021-pol2qm74	5998	14	patients	patient	NNS
cord-015021-pol2qm74	5998	15	following	follow	VBG
cord-015021-pol2qm74	5998	16	cardiac	cardiac	JJ
cord-015021-pol2qm74	5998	17	surgery	surgery	NN
cord-015021-pol2qm74	5998	18	.	.	.
cord-015021-pol2qm74	5999	1	SLS	SLS	NNP
cord-015021-pol2qm74	5999	2	is	be	VBZ
cord-015021-pol2qm74	5999	3	characterized	characterize	VBN
cord-015021-pol2qm74	5999	4	by	by	IN
cord-015021-pol2qm74	5999	5	a	a	DT
cord-015021-pol2qm74	5999	6	severe	severe	JJ
cord-015021-pol2qm74	5999	7	decrease	decrease	NN
cord-015021-pol2qm74	5999	8	in	in	IN
cord-015021-pol2qm74	5999	9	systemic	systemic	JJ
cord-015021-pol2qm74	5999	10	vascular	vascular	JJ
cord-015021-pol2qm74	5999	11	resistance	resistance	NN
cord-015021-pol2qm74	5999	12	requiring	require	VBG
cord-015021-pol2qm74	5999	13	the	the	DT
cord-015021-pol2qm74	5999	14	use	use	NN
cord-015021-pol2qm74	5999	15	of	of	IN
cord-015021-pol2qm74	5999	16	vasopressors	vasopressor	NNS
cord-015021-pol2qm74	5999	17	to	to	TO
cord-015021-pol2qm74	5999	18	maintain	maintain	VB
cord-015021-pol2qm74	5999	19	adequate	adequate	JJ
cord-015021-pol2qm74	5999	20	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	5999	21	in	in	IN
cord-015021-pol2qm74	5999	22	the	the	DT
cord-015021-pol2qm74	5999	23	presence	presence	NN
cord-015021-pol2qm74	5999	24	of	of	IN
cord-015021-pol2qm74	5999	25	negative	negative	JJ
cord-015021-pol2qm74	5999	26	blood	blood	NN
cord-015021-pol2qm74	5999	27	cultures	culture	NNS
cord-015021-pol2qm74	5999	28	.	.	.
cord-015021-pol2qm74	6000	1	In	in	IN
cord-015021-pol2qm74	6000	2	order	order	NN
cord-015021-pol2qm74	6000	3	to	to	TO
cord-015021-pol2qm74	6000	4	determine	determine	VB
cord-015021-pol2qm74	6000	5	whether	whether	IN
cord-015021-pol2qm74	6000	6	preoperative	preoperative	JJ
cord-015021-pol2qm74	6000	7	factors	factor	NNS
cord-015021-pol2qm74	6000	8	predict	predict	VBP
cord-015021-pol2qm74	6000	9	the	the	DT
cord-015021-pol2qm74	6000	10	occurrence	occurrence	NN
cord-015021-pol2qm74	6000	11	SLS	SLS	NNP
cord-015021-pol2qm74	6000	12	we	-PRON-	PRP
cord-015021-pol2qm74	6000	13	retrospectively	retrospectively	RB
cord-015021-pol2qm74	6000	14	studied	study	VBD
cord-015021-pol2qm74	6000	15	62	62	CD
cord-015021-pol2qm74	6000	16	patients	patient	NNS
cord-015021-pol2qm74	6000	17	with	with	IN
cord-015021-pol2qm74	6000	18	SLS	SLS	NNP
cord-015021-pol2qm74	6000	19	(	(	-LRB-
cord-015021-pol2qm74	6000	20	group	group	NN
cord-015021-pol2qm74	6000	21	i	i	PRP
cord-015021-pol2qm74	6000	22	:	:	:
cord-015021-pol2qm74	6000	23	age	age	NN
cord-015021-pol2qm74	6000	24	61.1	61.1	CD
cord-015021-pol2qm74	6000	25	~	~	NFP
cord-015021-pol2qm74	6000	26	10.8	10.8	CD
cord-015021-pol2qm74	6000	27	years	year	NNS
cord-015021-pol2qm74	6000	28	)	)	-RRB-
cord-015021-pol2qm74	6000	29	;	;	:
cord-015021-pol2qm74	6000	30	they	-PRON-	PRP
cord-015021-pol2qm74	6000	31	were	be	VBD
cord-015021-pol2qm74	6000	32	compared	compare	VBN
cord-015021-pol2qm74	6000	33	to	to	IN
cord-015021-pol2qm74	6000	34	52	52	CD
cord-015021-pol2qm74	6000	35	control	control	NN
cord-015021-pol2qm74	6000	36	patients	patient	NNS
cord-015021-pol2qm74	6000	37	(	(	-LRB-
cord-015021-pol2qm74	6000	38	group	group	NN
cord-015021-pol2qm74	6000	39	2	2	CD
cord-015021-pol2qm74	6000	40	:	:	:
cord-015021-pol2qm74	6000	41	age	age	NN
cord-015021-pol2qm74	6000	42	58	58	CD
cord-015021-pol2qm74	6000	43	±	±	CD
cord-015021-pol2qm74	6000	44	14.3	14.3	CD
cord-015021-pol2qm74	6000	45	years	year	NNS
cord-015021-pol2qm74	6000	46	)	)	-RRB-
cord-015021-pol2qm74	6000	47	.	.	.
cord-015021-pol2qm74	6001	1	Treatment	treatment	NN
cord-015021-pol2qm74	6001	2	of	of	IN
cord-015021-pol2qm74	6001	3	SLS	SLS	NNP
cord-015021-pol2qm74	6001	4	consisted	consist	VBD
cord-015021-pol2qm74	6001	5	of	of	IN
cord-015021-pol2qm74	6001	6	aggressive	aggressive	JJ
cord-015021-pol2qm74	6001	7	fluid	fluid	JJ
cord-015021-pol2qm74	6001	8	replacement	replacement	NN
cord-015021-pol2qm74	6001	9	and	and	CC
cord-015021-pol2qm74	6001	10	norepinephrine	norepinephrine	NN
cord-015021-pol2qm74	6001	11	infusion	infusion	NN
cord-015021-pol2qm74	6001	12	.	.	.
cord-015021-pol2qm74	6002	1	Rydrocortisone	Rydrocortisone	NNP
cord-015021-pol2qm74	6002	2	(	(	-LRB-
cord-015021-pol2qm74	6002	3	200	200	CD
cord-015021-pol2qm74	6002	4	mg/24	mg/24	CD
cord-015021-pol2qm74	6002	5	hrs	hrs	NN
cord-015021-pol2qm74	6002	6	)	)	-RRB-
cord-015021-pol2qm74	6002	7	was	be	VBD
cord-015021-pol2qm74	6002	8	given	give	VBN
cord-015021-pol2qm74	6002	9	on	on	IN
cord-015021-pol2qm74	6002	10	the	the	DT
cord-015021-pol2qm74	6002	11	first	first	JJ
cord-015021-pol2qm74	6002	12	day	day	NN
cord-015021-pol2qm74	6002	13	.	.	.
cord-015021-pol2qm74	6003	1	Antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6003	2	were	be	VBD
cord-015021-pol2qm74	6003	3	switched	switch	VBN
cord-015021-pol2qm74	6003	4	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	6003	5	to	to	TO
cord-015021-pol2qm74	6003	6	cover	cover	VB
cord-015021-pol2qm74	6003	7	gramnegative	gramnegative	JJ
cord-015021-pol2qm74	6003	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	6003	9	in	in	IN
cord-015021-pol2qm74	6003	10	48	48	CD
cord-015021-pol2qm74	6003	11	pts	pt	NNS
cord-015021-pol2qm74	6003	12	.	.	.
cord-015021-pol2qm74	6004	1	Preoperatively	Preoperatively	NNP
cord-015021-pol2qm74	6004	2	pts	pts	NNP
cord-015021-pol2qm74	6004	3	in	in	IN
cord-015021-pol2qm74	6004	4	group	group	NN
cord-015021-pol2qm74	6004	5	1	1	CD
cord-015021-pol2qm74	6004	6	revealed	reveal	VBD
cord-015021-pol2qm74	6004	7	a	a	DT
cord-015021-pol2qm74	6004	8	significantly	significantly	RB
cord-015021-pol2qm74	6004	9	lower	low	JJR
cord-015021-pol2qm74	6004	10	cardiac	cardiac	JJ
cord-015021-pol2qm74	6004	11	index	index	NN
cord-015021-pol2qm74	6004	12	(	(	-LRB-
cord-015021-pol2qm74	6004	13	2.5	2.5	CD
cord-015021-pol2qm74	6004	14	±	±	NNP
cord-015021-pol2qm74	6004	15	1	1	CD
cord-015021-pol2qm74	6004	16	i	i	NNP
cord-015021-pol2qm74	6004	17	/	/	SYM
cord-015021-pol2qm74	6004	18	min	min	NNP
cord-015021-pol2qm74	6004	19	/	/	SYM
cord-015021-pol2qm74	6004	20	m	m	NNP
cord-015021-pol2qm74	6004	21	2	2	CD
cord-015021-pol2qm74	6004	22	)	)	-RRB-
cord-015021-pol2qm74	6004	23	compared	compare	VBN
cord-015021-pol2qm74	6004	24	to	to	IN
cord-015021-pol2qm74	6004	25	group	group	NN
cord-015021-pol2qm74	6004	26	2	2	CD
cord-015021-pol2qm74	6004	27	(	(	-LRB-
cord-015021-pol2qm74	6004	28	3.1	3.1	CD
cord-015021-pol2qm74	6004	29	±	±	CD
cord-015021-pol2qm74	6004	30	1.2	1.2	CD
cord-015021-pol2qm74	6004	31	i	i	NNP
cord-015021-pol2qm74	6004	32	/	/	SYM
cord-015021-pol2qm74	6004	33	min	min	NNP
cord-015021-pol2qm74	6004	34	/	/	SYM
cord-015021-pol2qm74	6004	35	m2	m2	NNP
cord-015021-pol2qm74	6004	36	;	;	:
cord-015021-pol2qm74	6004	37	p	p	NN
cord-015021-pol2qm74	6004	38	<	<	XX
cord-015021-pol2qm74	6004	39	.02	.02	NFP
cord-015021-pol2qm74	6004	40	)	)	-RRB-
cord-015021-pol2qm74	6005	1	higher	high	JJR
cord-015021-pol2qm74	6005	2	left	left	JJ
cord-015021-pol2qm74	6005	3	atrial	atrial	JJ
cord-015021-pol2qm74	6005	4	pressure	pressure	NN
cord-015021-pol2qm74	6005	5	(	(	-LRB-
cord-015021-pol2qm74	6005	6	group	group	NN
cord-015021-pol2qm74	6005	7	i	i	PRP
cord-015021-pol2qm74	6005	8	:	:	:
cord-015021-pol2qm74	6005	9	17.8	17.8	CD
cord-015021-pol2qm74	6005	10	~	~	NFP
cord-015021-pol2qm74	6005	11	8.1	8.1	CD
cord-015021-pol2qm74	6005	12	mmHg	mmHg	NNS
cord-015021-pol2qm74	6005	13	;	;	:
cord-015021-pol2qm74	6005	14	group	group	NN
cord-015021-pol2qm74	6005	15	2	2	CD
cord-015021-pol2qm74	6005	16	:	:	:
cord-015021-pol2qm74	6005	17	13.1	13.1	CD
cord-015021-pol2qm74	6005	18	~	~	NFP
cord-015021-pol2qm74	6005	19	6.1	6.1	CD
cord-015021-pol2qm74	6005	20	mmHg	mmHg	NNS
cord-015021-pol2qm74	6005	21	;	;	:
cord-015021-pol2qm74	6005	22	p	p	NN
cord-015021-pol2qm74	6005	23	<	<	XX
cord-015021-pol2qm74	6005	24	.005	.005	NFP
cord-015021-pol2qm74	6005	25	)	)	-RRB-
cord-015021-pol2qm74	6005	26	and	and	CC
cord-015021-pol2qm74	6005	27	lower	low	JJR
cord-015021-pol2qm74	6005	28	ejection	ejection	NN
cord-015021-pol2qm74	6005	29	fraction	fraction	NN
cord-015021-pol2qm74	6006	1	(	(	-LRB-
cord-015021-pol2qm74	6006	2	group	group	NN
cord-015021-pol2qm74	6006	3	i	i	PRP
cord-015021-pol2qm74	6006	4	:	:	:
cord-015021-pol2qm74	6006	5	57.9	57.9	CD
cord-015021-pol2qm74	6006	6	Z	z	NN
cord-015021-pol2qm74	6006	7	16.3	16.3	CD
cord-015021-pol2qm74	6006	8	%	%	NN
cord-015021-pol2qm74	6006	9	;	;	:
cord-015021-pol2qm74	6006	10	group	group	NN
cord-015021-pol2qm74	6006	11	2	2	CD
cord-015021-pol2qm74	6006	12	65.2	65.2	CD
cord-015021-pol2qm74	6006	13	±	±	CD
cord-015021-pol2qm74	6006	14	10.9	10.9	CD
cord-015021-pol2qm74	6006	15	%	%	NN
cord-015021-pol2qm74	6006	16	;	;	:
cord-015021-pol2qm74	6006	17	p	p	NN
cord-015021-pol2qm74	6006	18	<	<	XX
cord-015021-pol2qm74	6006	19	.03	.03	NFP
cord-015021-pol2qm74	6006	20	)	)	-RRB-
cord-015021-pol2qm74	6006	21	.	.	.
cord-015021-pol2qm74	6007	1	Bypass	bypass	NN
cord-015021-pol2qm74	6007	2	time	time	NN
cord-015021-pol2qm74	6007	3	,	,	,
cord-015021-pol2qm74	6007	4	minimum	minimum	NN
cord-015021-pol2qm74	6007	5	and	and	CC
cord-015021-pol2qm74	6007	6	mean	mean	VB
cord-015021-pol2qm74	6007	7	blood	blood	NN
cord-015021-pol2qm74	6007	8	pressure	pressure	NN
cord-015021-pol2qm74	6007	9	on	on	IN
cord-015021-pol2qm74	6007	10	bypass	bypass	NN
cord-015021-pol2qm74	6007	11	and	and	CC
cord-015021-pol2qm74	6007	12	aortic	aortic	JJ
cord-015021-pol2qm74	6007	13	clamp	clamp	NN
cord-015021-pol2qm74	6007	14	time	time	NN
cord-015021-pol2qm74	6007	15	were	be	VBD
cord-015021-pol2qm74	6007	16	not	not	RB
cord-015021-pol2qm74	6007	17	different	different	JJ
cord-015021-pol2qm74	6007	18	between	between	IN
cord-015021-pol2qm74	6007	19	the	the	DT
cord-015021-pol2qm74	6007	20	groups	group	NNS
cord-015021-pol2qm74	6007	21	.	.	.
cord-015021-pol2qm74	6008	1	Immediately	immediately	RB
cord-015021-pol2qm74	6008	2	postoperatively	postoperatively	DT
cord-015021-pol2qm74	6008	3	(	(	-LRB-
cord-015021-pol2qm74	6008	4	pop	pop	NN
cord-015021-pol2qm74	6008	5	)	)	-RRB-
cord-015021-pol2qm74	6008	6	,	,	,
cord-015021-pol2qm74	6008	7	the	the	DT
cord-015021-pol2qm74	6008	8	white	white	JJ
cord-015021-pol2qm74	6008	9	blood	blood	NN
cord-015021-pol2qm74	6008	10	count	count	NN
cord-015021-pol2qm74	6008	11	was	be	VBD
cord-015021-pol2qm74	6008	12	elevated	elevate	VBN
cord-015021-pol2qm74	6008	13	(	(	-LRB-
cord-015021-pol2qm74	6008	14	group	group	NN
cord-015021-pol2qm74	6008	15	i	i	PRP
cord-015021-pol2qm74	6008	16	:	:	:
cord-015021-pol2qm74	6008	17	15,700	15,700	CD
cord-015021-pol2qm74	6009	1	±	±	NNP
cord-015021-pol2qm74	6009	2	8,200	8,200	CD
cord-015021-pol2qm74	6009	3	/	/	SYM
cord-015021-pol2qm74	6009	4	ui	ui	NNP
cord-015021-pol2qm74	6009	5	;	;	:
cord-015021-pol2qm74	6009	6	group	group	NNP
cord-015021-pol2qm74	6009	7	2	2	CD
cord-015021-pol2qm74	6009	8	:	:	:
cord-015021-pol2qm74	6010	1	10,200	10,200	CD
cord-015021-pol2qm74	6010	2	~	~	CD
cord-015021-pol2qm74	6010	3	4,400	4,400	CD
cord-015021-pol2qm74	6010	4	/	/	SYM
cord-015021-pol2qm74	6010	5	ui	ui	NNP
cord-015021-pol2qm74	6010	6	;	;	:
cord-015021-pol2qm74	6010	7	p	p	NN
cord-015021-pol2qm74	6010	8	<	<	XX
cord-015021-pol2qm74	6010	9	.0005	.0005	XX
cord-015021-pol2qm74	6010	10	)	)	-RRB-
cord-015021-pol2qm74	6011	1	and	and	CC
cord-015021-pol2qm74	6011	2	core	core	NN
cord-015021-pol2qm74	6011	3	temperature	temperature	NN
cord-015021-pol2qm74	6011	4	12	12	CD
cord-015021-pol2qm74	6011	5	hours	hour	NNS
cord-015021-pol2qm74	6011	6	pop	pop	NN
cord-015021-pol2qm74	6011	7	was	be	VBD
cord-015021-pol2qm74	6011	8	higher	high	JJR
cord-015021-pol2qm74	6012	1	(	(	-LRB-
cord-015021-pol2qm74	6012	2	group	group	NN
cord-015021-pol2qm74	6012	3	i	i	PRP
cord-015021-pol2qm74	6012	4	:	:	:
cord-015021-pol2qm74	6012	5	38.3	38.3	CD
cord-015021-pol2qm74	6012	6	7.6	7.6	CD
cord-015021-pol2qm74	6012	7	°	°	NN
cord-015021-pol2qm74	6012	8	C	c	NN
cord-015021-pol2qm74	6012	9	;	;	:
cord-015021-pol2qm74	6012	10	group	group	NN
cord-015021-pol2qm74	6012	11	2	2	CD
cord-015021-pol2qm74	6012	12	:	:	:
cord-015021-pol2qm74	6012	13	37.6	37.6	CD
cord-015021-pol2qm74	6012	14	~	~	CD
cord-015021-pol2qm74	6012	15	8.4	8.4	CD
cord-015021-pol2qm74	6012	16	°	°	NN
cord-015021-pol2qm74	6012	17	C	c	NN
cord-015021-pol2qm74	6012	18	;	;	:
cord-015021-pol2qm74	6012	19	p	p	NN
cord-015021-pol2qm74	6012	20	<	<	XX
cord-015021-pol2qm74	6012	21	.004	.004	CD
cord-015021-pol2qm74	6012	22	)	)	-RRB-
cord-015021-pol2qm74	6012	23	.	.	.
cord-015021-pol2qm74	6013	1	Serum	serum	NN
cord-015021-pol2qm74	6013	2	lactate	lactate	NN
cord-015021-pol2qm74	6013	3	was	be	VBD
cord-015021-pol2qm74	6013	4	already	already	RB
cord-015021-pol2qm74	6013	5	elevated	elevate	VBN
cord-015021-pol2qm74	6013	6	on	on	IN
cord-015021-pol2qm74	6013	7	arrival	arrival	NN
cord-015021-pol2qm74	6013	8	on	on	IN
cord-015021-pol2qm74	6013	9	the	the	DT
cord-015021-pol2qm74	6013	10	ICU	ICU	NNP
cord-015021-pol2qm74	6013	11	pop	pop	NN
cord-015021-pol2qm74	6013	12	(	(	-LRB-
cord-015021-pol2qm74	6013	13	group	group	NN
cord-015021-pol2qm74	6013	14	I	-PRON-	PRP
cord-015021-pol2qm74	6013	15	:	:	:
cord-015021-pol2qm74	6013	16	5,0	5,0	CD
cord-015021-pol2qm74	6013	17	Z	z	NN
cord-015021-pol2qm74	6013	18	1.9	1.9	CD
cord-015021-pol2qm74	6013	19	mmol	mmol	NNP
cord-015021-pol2qm74	6013	20	/	/	SYM
cord-015021-pol2qm74	6013	21	l	l	NN
cord-015021-pol2qm74	6013	22	,	,	,
cord-015021-pol2qm74	6013	23	group	group	NN
cord-015021-pol2qm74	6013	24	2	2	CD
cord-015021-pol2qm74	6013	25	:	:	:
cord-015021-pol2qm74	6013	26	2.2	2.2	CD
cord-015021-pol2qm74	6013	27	~	~	NFP
cord-015021-pol2qm74	6013	28	0.9	0.9	CD
cord-015021-pol2qm74	6013	29	mmol	mmol	NN
cord-015021-pol2qm74	6013	30	/	/	SYM
cord-015021-pol2qm74	6013	31	l	l	NN
cord-015021-pol2qm74	6013	32	)	)	-RRB-
cord-015021-pol2qm74	6013	33	but	but	CC
cord-015021-pol2qm74	6013	34	dropped	drop	VBD
cord-015021-pol2qm74	6013	35	within	within	IN
cord-015021-pol2qm74	6013	36	24	24	CD
cord-015021-pol2qm74	6013	37	hours	hour	NNS
cord-015021-pol2qm74	6013	38	(	(	-LRB-
cord-015021-pol2qm74	6013	39	p	p	NN
cord-015021-pol2qm74	6013	40	<	<	XX
cord-015021-pol2qm74	6013	41	.0005	.0005	NNP
cord-015021-pol2qm74	6013	42	)	)	-RRB-
cord-015021-pol2qm74	6013	43	.	.	.
cord-015021-pol2qm74	6014	1	ICU	ICU	NNP
cord-015021-pol2qm74	6014	2	stay	stay	VBP
cord-015021-pol2qm74	6014	3	(	(	-LRB-
cord-015021-pol2qm74	6014	4	group	group	NN
cord-015021-pol2qm74	6014	5	i	i	PRP
cord-015021-pol2qm74	6014	6	:	:	:
cord-015021-pol2qm74	6014	7	3.7	3.7	CD
cord-015021-pol2qm74	6014	8	!	!	.
cord-015021-pol2qm74	6014	9	4.3	4.3	CD
cord-015021-pol2qm74	6014	10	;	;	:
cord-015021-pol2qm74	6014	11	group	group	NN
cord-015021-pol2qm74	6014	12	2	2	CD
cord-015021-pol2qm74	6014	13	:	:	:
cord-015021-pol2qm74	6014	14	1.6	1.6	CD
cord-015021-pol2qm74	6014	15	±	±	CD
cord-015021-pol2qm74	6014	16	1.9	1.9	CD
cord-015021-pol2qm74	6014	17	days	day	NNS
cord-015021-pol2qm74	6014	18	;	;	:
cord-015021-pol2qm74	6014	19	p	p	NN
cord-015021-pol2qm74	6014	20	<	<	XX
cord-015021-pol2qm74	6014	21	0.001	0.001	CD
cord-015021-pol2qm74	6014	22	)	)	-RRB-
cord-015021-pol2qm74	6014	23	and	and	CC
cord-015021-pol2qm74	6014	24	mortality	mortality	NN
cord-015021-pol2qm74	6014	25	over	over	IN
cord-015021-pol2qm74	6014	26	3	3	CD
cord-015021-pol2qm74	6014	27	months	month	NNS
cord-015021-pol2qm74	6015	1	(	(	-LRB-
cord-015021-pol2qm74	6015	2	group	group	NN
cord-015021-pol2qm74	6015	3	I	-PRON-	PRP
cord-015021-pol2qm74	6015	4	:	:	:
cord-015021-pol2qm74	6015	5	19.1	19.1	CD
cord-015021-pol2qm74	6015	6	%	%	NN
cord-015021-pol2qm74	6015	7	;	;	:
cord-015021-pol2qm74	6015	8	group	group	NN
cord-015021-pol2qm74	6015	9	2	2	CD
cord-015021-pol2qm74	6015	10	:	:	:
cord-015021-pol2qm74	6015	11	3.1	3.1	CD
cord-015021-pol2qm74	6015	12	%	%	NN
cord-015021-pol2qm74	6015	13	;	;	:
cord-015021-pol2qm74	6015	14	p	p	NN
cord-015021-pol2qm74	6015	15	<	<	XX
cord-015021-pol2qm74	6015	16	.005	.005	NFP
cord-015021-pol2qm74	6015	17	)	)	-RRB-
cord-015021-pol2qm74	6015	18	were	be	VBD
cord-015021-pol2qm74	6015	19	significant	significant	JJ
cord-015021-pol2qm74	6015	20	higher	higher	RBR
cord-015021-pol2qm74	6015	21	in	in	IN
cord-015021-pol2qm74	6016	1	group	group	NN
cord-015021-pol2qm74	6016	2	i.	i.	NNP
cord-015021-pol2qm74	6016	3	SLS	SLS	NNP
cord-015021-pol2qm74	6016	4	is	be	VBZ
cord-015021-pol2qm74	6016	5	observed	observe	VBN
cord-015021-pol2qm74	6016	6	more	more	RBR
cord-015021-pol2qm74	6016	7	frequently	frequently	RB
cord-015021-pol2qm74	6016	8	in	in	IN
cord-015021-pol2qm74	6016	9	patients	patient	NNS
cord-015021-pol2qm74	6016	10	with	with	IN
cord-015021-pol2qm74	6016	11	preoperative	preoperative	JJ
cord-015021-pol2qm74	6016	12	cardiac	cardiac	JJ
cord-015021-pol2qm74	6016	13	congestion	congestion	NN
cord-015021-pol2qm74	6016	14	and	and	CC
cord-015021-pol2qm74	6016	15	results	result	NNS
cord-015021-pol2qm74	6016	16	in	in	IN
cord-015021-pol2qm74	6016	17	longer	long	JJR
cord-015021-pol2qm74	6016	18	ICU	ICU	NNP
cord-015021-pol2qm74	6016	19	stay	stay	NN
cord-015021-pol2qm74	6016	20	and	and	CC
cord-015021-pol2qm74	6016	21	higher	high	JJR
cord-015021-pol2qm74	6016	22	mortality	mortality	NN
cord-015021-pol2qm74	6016	23	.	.	.
cord-015021-pol2qm74	6017	1	Although	although	IN
cord-015021-pol2qm74	6017	2	intraoperative	intraoperative	JJ
cord-015021-pol2qm74	6017	3	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	6017	4	are	be	VBP
cord-015021-pol2qm74	6017	5	similar	similar	JJ
cord-015021-pol2qm74	6017	6	in	in	IN
cord-015021-pol2qm74	6017	7	both	both	DT
cord-015021-pol2qm74	6017	8	groups	group	NNS
cord-015021-pol2qm74	6017	9	,	,	,
cord-015021-pol2qm74	6017	10	the	the	DT
cord-015021-pol2qm74	6017	11	white	white	JJ
cord-015021-pol2qm74	6017	12	blood	blood	NN
cord-015021-pol2qm74	6017	13	count	count	NN
cord-015021-pol2qm74	6017	14	and	and	CC
cord-015021-pol2qm74	6017	15	serum	serum	NN
cord-015021-pol2qm74	6017	16	lactate	lactate	NN
cord-015021-pol2qm74	6017	17	levels	level	NNS
cord-015021-pol2qm74	6017	18	suggest	suggest	VBP
cord-015021-pol2qm74	6017	19	an	an	DT
cord-015021-pol2qm74	6017	20	intraoperative	intraoperative	JJ
cord-015021-pol2qm74	6017	21	cause	cause	NN
cord-015021-pol2qm74	6017	22	for	for	IN
cord-015021-pol2qm74	6017	23	SLS	SLS	NNP
cord-015021-pol2qm74	6017	24	.	.	.
cord-015021-pol2qm74	6018	1	Further	further	JJ
cord-015021-pol2qm74	6018	2	investigations	investigation	NNS
cord-015021-pol2qm74	6018	3	will	will	MD
cord-015021-pol2qm74	6018	4	focus	focus	VB
cord-015021-pol2qm74	6018	5	on	on	IN
cord-015021-pol2qm74	6018	6	possible	possible	JJ
cord-015021-pol2qm74	6018	7	intraoperative	intraoperative	JJ
cord-015021-pol2qm74	6018	8	causes	cause	NNS
cord-015021-pol2qm74	6018	9	of	of	IN
cord-015021-pol2qm74	6018	10	SLS	SLS	NNP
cord-015021-pol2qm74	6018	11	.	.	.
cord-015021-pol2qm74	6019	1	The	the	DT
cord-015021-pol2qm74	6019	2	objectives	objective	NNS
cord-015021-pol2qm74	6019	3	of	of	IN
cord-015021-pol2qm74	6019	4	the	the	DT
cord-015021-pol2qm74	6019	5	study	study	NN
cord-015021-pol2qm74	6019	6	were	be	VBD
cord-015021-pol2qm74	6019	7	to	to	TO
cord-015021-pol2qm74	6019	8	estimate	estimate	VB
cord-015021-pol2qm74	6019	9	the	the	DT
cord-015021-pol2qm74	6019	10	problem	problem	NN
cord-015021-pol2qm74	6019	11	of	of	IN
cord-015021-pol2qm74	6019	12	stress	stress	NN
cord-015021-pol2qm74	6019	13	ulcers	ulcer	NNS
cord-015021-pol2qm74	6019	14	in	in	IN
cord-015021-pol2qm74	6019	15	critically	critically	RB
cord-015021-pol2qm74	6019	16	ill	ill	JJ
cord-015021-pol2qm74	6019	17	patients	patient	NNS
cord-015021-pol2qm74	6019	18	and	and	CC
cord-015021-pol2qm74	6019	19	to	to	TO
cord-015021-pol2qm74	6019	20	compare	compare	VB
cord-015021-pol2qm74	6019	21	Ranitidine	Ranitidine	NNP
cord-015021-pol2qm74	6019	22	and	and	CC
cord-015021-pol2qm74	6019	23	Omeprazole	Omeprazole	NNP
cord-015021-pol2qm74	6019	24	to	to	TO
cord-015021-pol2qm74	6019	25	determine	determine	VB
cord-015021-pol2qm74	6019	26	their	-PRON-	PRP$
cord-015021-pol2qm74	6019	27	efficacy	efficacy	NN
cord-015021-pol2qm74	6019	28	in	in	IN
cord-015021-pol2qm74	6019	29	the	the	DT
cord-015021-pol2qm74	6019	30	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	6019	31	of	of	IN
cord-015021-pol2qm74	6019	32	stress	stress	NN
cord-015021-pol2qm74	6019	33	ulcers	ulcer	NNS
cord-015021-pol2qm74	6019	34	.	.	.
cord-015021-pol2qm74	6020	1	33	33	CD
cord-015021-pol2qm74	6020	2	patients	patient	NNS
cord-015021-pol2qm74	6020	3	who	who	WP
cord-015021-pol2qm74	6020	4	were	be	VBD
cord-015021-pol2qm74	6020	5	admitted	admit	VBN
cord-015021-pol2qm74	6020	6	to	to	IN
cord-015021-pol2qm74	6020	7	the	the	DT
cord-015021-pol2qm74	6020	8	Intensive	Intensive	NNP
cord-015021-pol2qm74	6020	9	Care	Care	NNP
cord-015021-pol2qm74	6020	10	Units	Units	NNPS
cord-015021-pol2qm74	6020	11	between	between	IN
cord-015021-pol2qm74	6020	12	January	January	NNP
cord-015021-pol2qm74	6020	13	and	and	CC
cord-015021-pol2qm74	6020	14	July	July	NNP
cord-015021-pol2qm74	6020	15	'	'	POS
cord-015021-pol2qm74	6020	16	92	92	CD
cord-015021-pol2qm74	6020	17	with	with	IN
cord-015021-pol2qm74	6020	18	polytrauma	polytrauma	NN
cord-015021-pol2qm74	6020	19	,	,	,
cord-015021-pol2qm74	6020	20	sepsis	sepsis	NN
cord-015021-pol2qm74	6020	21	or	or	CC
cord-015021-pol2qm74	6020	22	those	those	DT
cord-015021-pol2qm74	6020	23	requiring	require	VBG
cord-015021-pol2qm74	6020	24	ventilatory	ventilatory	JJ
cord-015021-pol2qm74	6020	25	support	support	NN
cord-015021-pol2qm74	6020	26	for	for	IN
cord-015021-pol2qm74	6020	27	more	more	JJR
cord-015021-pol2qm74	6020	28	than	than	IN
cord-015021-pol2qm74	6020	29	48	48	CD
cord-015021-pol2qm74	6020	30	hours	hour	NNS
cord-015021-pol2qm74	6020	31	were	be	VBD
cord-015021-pol2qm74	6020	32	selected	select	VBN
cord-015021-pol2qm74	6020	33	for	for	IN
cord-015021-pol2qm74	6020	34	the	the	DT
cord-015021-pol2qm74	6020	35	study	study	NN
cord-015021-pol2qm74	6020	36	.	.	.
cord-015021-pol2qm74	6021	1	The	the	DT
cord-015021-pol2qm74	6021	2	patients	patient	NNS
cord-015021-pol2qm74	6021	3	were	be	VBD
cord-015021-pol2qm74	6021	4	randomized	randomize	VBN
cord-015021-pol2qm74	6021	5	into	into	IN
cord-015021-pol2qm74	6021	6	3	3	CD
cord-015021-pol2qm74	6021	7	groups	group	NNS
cord-015021-pol2qm74	6021	8	to	to	TO
cord-015021-pol2qm74	6021	9	receive	receive	VB
cord-015021-pol2qm74	6021	10	Ranitidine	Ranitidine	NNP
cord-015021-pol2qm74	6021	11	,	,	,
cord-015021-pol2qm74	6021	12	Omeprazole	Omeprazole	NNP
cord-015021-pol2qm74	6021	13	or	or	CC
cord-015021-pol2qm74	6021	14	a	a	DT
cord-015021-pol2qm74	6021	15	placebo	placebo	NN
cord-015021-pol2qm74	6021	16	.	.	.
cord-015021-pol2qm74	6022	1	The	the	DT
cord-015021-pol2qm74	6022	2	changes	change	NNS
cord-015021-pol2qm74	6022	3	in	in	IN
cord-015021-pol2qm74	6022	4	gastric	gastric	JJ
cord-015021-pol2qm74	6022	5	pH	ph	NN
cord-015021-pol2qm74	6022	6	were	be	VBD
cord-015021-pol2qm74	6022	7	monitored	monitor	VBN
cord-015021-pol2qm74	6022	8	4	4	CD
cord-015021-pol2qm74	6022	9	hourly	hourly	JJ
cord-015021-pol2qm74	6022	10	and	and	CC
cord-015021-pol2qm74	6022	11	the	the	DT
cord-015021-pol2qm74	6022	12	patients	patient	NNS
cord-015021-pol2qm74	6022	13	underwent	undergo	VBD
cord-015021-pol2qm74	6022	14	an	an	DT
cord-015021-pol2qm74	6022	15	upper	upper	JJ
cord-015021-pol2qm74	6022	16	GI	GI	NNP
cord-015021-pol2qm74	6022	17	endoscopy	endoscopy	NN
cord-015021-pol2qm74	6022	18	48	48	CD
cord-015021-pol2qm74	6022	19	hours	hour	NNS
cord-015021-pol2qm74	6022	20	after	after	IN
cord-015021-pol2qm74	6022	21	the	the	DT
cord-015021-pol2qm74	6022	22	start	start	NN
cord-015021-pol2qm74	6022	23	of	of	IN
cord-015021-pol2qm74	6022	24	the	the	DT
cord-015021-pol2qm74	6022	25	study	study	NN
cord-015021-pol2qm74	6022	26	to	to	TO
cord-015021-pol2qm74	6022	27	look	look	VB
cord-015021-pol2qm74	6022	28	for	for	IN
cord-015021-pol2qm74	6022	29	stress	stress	NN
cord-015021-pol2qm74	6022	30	ulcers	ulcer	NNS
cord-015021-pol2qm74	6022	31	and	and	CC
cord-015021-pol2qm74	6022	32	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6022	33	.	.	.
cord-015021-pol2qm74	6023	1	The	the	DT
cord-015021-pol2qm74	6023	2	drugs	drug	NNS
cord-015021-pol2qm74	6023	3	were	be	VBD
cord-015021-pol2qm74	6023	4	withdrawn	withdraw	VBN
cord-015021-pol2qm74	6023	5	one	one	CD
cord-015021-pol2qm74	6023	6	week	week	NN
cord-015021-pol2qm74	6023	7	after	after	IN
cord-015021-pol2qm74	6023	8	the	the	DT
cord-015021-pol2qm74	6023	9	start	start	NN
cord-015021-pol2qm74	6023	10	of	of	IN
cord-015021-pol2qm74	6023	11	the	the	DT
cord-015021-pol2qm74	6023	12	study	study	NN
cord-015021-pol2qm74	6023	13	.	.	.
cord-015021-pol2qm74	6024	1	Of	of	IN
cord-015021-pol2qm74	6024	2	the	the	DT
cord-015021-pol2qm74	6024	3	33	33	CD
cord-015021-pol2qm74	6024	4	patients	patient	NNS
cord-015021-pol2qm74	6024	5	selected	select	VBN
cord-015021-pol2qm74	6024	6	for	for	IN
cord-015021-pol2qm74	6024	7	the	the	DT
cord-015021-pol2qm74	6024	8	study	study	NN
cord-015021-pol2qm74	6024	9	,	,	,
cord-015021-pol2qm74	6024	10	14	14	CD
cord-015021-pol2qm74	6024	11	had	have	VBD
cord-015021-pol2qm74	6024	12	undergone	undergo	VBN
cord-015021-pol2qm74	6024	13	cardiac	cardiac	JJ
cord-015021-pol2qm74	6024	14	surgery	surgery	NN
cord-015021-pol2qm74	6024	15	,	,	,
cord-015021-pol2qm74	6024	16	6	6	CD
cord-015021-pol2qm74	6024	17	had	have	VBD
cord-015021-pol2qm74	6024	18	polytrauma	polytrauma	NN
cord-015021-pol2qm74	6024	19	and	and	CC
cord-015021-pol2qm74	6024	20	13	13	CD
cord-015021-pol2qm74	6024	21	had	have	VBD
cord-015021-pol2qm74	6024	22	sepsis	sepsis	NN
cord-015021-pol2qm74	6024	23	.	.	.
cord-015021-pol2qm74	6025	1	The	the	DT
cord-015021-pol2qm74	6025	2	change	change	NN
cord-015021-pol2qm74	6025	3	in	in	IN
cord-015021-pol2qm74	6025	4	average	average	JJ
cord-015021-pol2qm74	6025	5	pre	pre	JJ
cord-015021-pol2qm74	6025	6	and	and	CC
cord-015021-pol2qm74	6025	7	post	post	JJ
cord-015021-pol2qm74	6025	8	drug	drug	NN
cord-015021-pol2qm74	6025	9	gastric	gastric	NN
cord-015021-pol2qm74	6025	10	pH	ph	NN
cord-015021-pol2qm74	6025	11	was	be	VBD
cord-015021-pol2qm74	6025	12	+1.1	+1.1	CD
cord-015021-pol2qm74	6025	13	in	in	IN
cord-015021-pol2qm74	6025	14	the	the	DT
cord-015021-pol2qm74	6025	15	Omeprazole	Omeprazole	NNP
cord-015021-pol2qm74	6025	16	group	group	NN
cord-015021-pol2qm74	6025	17	,	,	,
cord-015021-pol2qm74	6025	18	+0.5	+0.5	NNP
cord-015021-pol2qm74	6025	19	in	in	IN
cord-015021-pol2qm74	6025	20	the	the	DT
cord-015021-pol2qm74	6025	21	Ranitidine	Ranitidine	NNP
cord-015021-pol2qm74	6025	22	group	group	NN
cord-015021-pol2qm74	6025	23	and	and	CC
cord-015021-pol2qm74	6025	24	-).9	-).9	NN
cord-015021-pol2qm74	6025	25	in	in	IN
cord-015021-pol2qm74	6025	26	the	the	DT
cord-015021-pol2qm74	6025	27	placebo	placebo	NN
cord-015021-pol2qm74	6025	28	group	group	NN
cord-015021-pol2qm74	6025	29	(	(	-LRB-
cord-015021-pol2qm74	6025	30	p	p	NN
cord-015021-pol2qm74	6025	31	<	<	XX
cord-015021-pol2qm74	6025	32	0.05	0.05	CD
cord-015021-pol2qm74	6025	33	)	)	-RRB-
cord-015021-pol2qm74	6025	34	.	.	.
cord-015021-pol2qm74	6026	1	Endoscopic	endoscopic	JJ
cord-015021-pol2qm74	6026	2	evidence	evidence	NN
cord-015021-pol2qm74	6026	3	of	of	IN
cord-015021-pol2qm74	6026	4	stress	stress	NN
cord-015021-pol2qm74	6026	5	ulcers	ulcer	NNS
cord-015021-pol2qm74	6026	6	was	be	VBD
cord-015021-pol2qm74	6026	7	seen	see	VBN
cord-015021-pol2qm74	6026	8	in	in	IN
cord-015021-pol2qm74	6026	9	62	62	CD
cord-015021-pol2qm74	6026	10	%	%	NN
cord-015021-pol2qm74	6026	11	of	of	IN
cord-015021-pol2qm74	6026	12	patients	patient	NNS
cord-015021-pol2qm74	6026	13	not	not	RB
cord-015021-pol2qm74	6026	14	on	on	IN
cord-015021-pol2qm74	6026	15	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	6026	16	,	,	,
cord-015021-pol2qm74	6026	17	18.1	18.1	CD
cord-015021-pol2qm74	6026	18	%	%	NN
cord-015021-pol2qm74	6026	19	of	of	IN
cord-015021-pol2qm74	6026	20	those	those	DT
cord-015021-pol2qm74	6026	21	on	on	IN
cord-015021-pol2qm74	6026	22	Omeprazole	Omeprazole	NNP
cord-015021-pol2qm74	6026	23	and	and	CC
cord-015021-pol2qm74	6026	24	54.5	54.5	CD
cord-015021-pol2qm74	6026	25	%	%	NN
cord-015021-pol2qm74	6026	26	of	of	IN
cord-015021-pol2qm74	6026	27	those	those	DT
cord-015021-pol2qm74	6026	28	on	on	IN
cord-015021-pol2qm74	6026	29	Ranitidine	Ranitidine	NNP
cord-015021-pol2qm74	6026	30	.	.	.
cord-015021-pol2qm74	6027	1	While	while	IN
cord-015021-pol2qm74	6027	2	all	all	PDT
cord-015021-pol2qm74	6027	3	the	the	DT
cord-015021-pol2qm74	6027	4	patients	patient	NNS
cord-015021-pol2qm74	6027	5	in	in	IN
cord-015021-pol2qm74	6027	6	the	the	DT
cord-015021-pol2qm74	6027	7	placebo	placebo	NN
cord-015021-pol2qm74	6027	8	group	group	NN
cord-015021-pol2qm74	6027	9	who	who	WP
cord-015021-pol2qm74	6027	10	had	have	VBD
cord-015021-pol2qm74	6027	11	stress	stress	NN
cord-015021-pol2qm74	6027	12	ulcers	ulcer	NNS
cord-015021-pol2qm74	6027	13	showed	show	VBD
cord-015021-pol2qm74	6027	14	endoscopic	endoscopic	JJ
cord-015021-pol2qm74	6027	15	evidence	evidence	NN
cord-015021-pol2qm74	6027	16	of	of	IN
cord-015021-pol2qm74	6027	17	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6027	18	,	,	,
cord-015021-pol2qm74	6027	19	82	82	CD
cord-015021-pol2qm74	6027	20	%	%	NN
cord-015021-pol2qm74	6027	21	of	of	IN
cord-015021-pol2qm74	6027	22	the	the	DT
cord-015021-pol2qm74	6027	23	patients	patient	NNS
cord-015021-pol2qm74	6027	24	with	with	IN
cord-015021-pol2qm74	6027	25	ulcers	ulcer	NNS
cord-015021-pol2qm74	6027	26	in	in	IN
cord-015021-pol2qm74	6027	27	the	the	DT
cord-015021-pol2qm74	6027	28	Ranitidine	Ranitidine	NNP
cord-015021-pol2qm74	6027	29	group	group	NN
cord-015021-pol2qm74	6027	30	and	and	CC
cord-015021-pol2qm74	6027	31	none	none	NN
cord-015021-pol2qm74	6027	32	of	of	IN
cord-015021-pol2qm74	6027	33	the	the	DT
cord-015021-pol2qm74	6027	34	patients	patient	NNS
cord-015021-pol2qm74	6027	35	with	with	IN
cord-015021-pol2qm74	6027	36	ulcers	ulcer	NNS
cord-015021-pol2qm74	6027	37	in	in	IN
cord-015021-pol2qm74	6027	38	the	the	DT
cord-015021-pol2qm74	6027	39	Omeprazole	Omeprazole	NNP
cord-015021-pol2qm74	6027	40	group	group	NN
cord-015021-pol2qm74	6027	41	showed	show	VBD
cord-015021-pol2qm74	6027	42	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6028	1	(	(	-LRB-
cord-015021-pol2qm74	6028	2	p	p	NN
cord-015021-pol2qm74	6028	3	<	<	XX
cord-015021-pol2qm74	6028	4	0.01	0.01	CD
cord-015021-pol2qm74	6028	5	)	)	-RRB-
cord-015021-pol2qm74	6028	6	.	.	.
cord-015021-pol2qm74	6029	1	In	in	IN
cord-015021-pol2qm74	6029	2	critically	critically	RB
cord-015021-pol2qm74	6029	3	ill	ill	JJ
cord-015021-pol2qm74	6029	4	patients	patient	NNS
cord-015021-pol2qm74	6029	5	the	the	DT
cord-015021-pol2qm74	6029	6	incidence	incidence	NN
cord-015021-pol2qm74	6029	7	of	of	IN
cord-015021-pol2qm74	6029	8	stress	stress	NN
cord-015021-pol2qm74	6029	9	ulceration	ulceration	NN
cord-015021-pol2qm74	6029	10	is	be	VBZ
cord-015021-pol2qm74	6029	11	high	high	JJ
cord-015021-pol2qm74	6029	12	.	.	.
cord-015021-pol2qm74	6030	1	An	an	DT
cord-015021-pol2qm74	6030	2	alkaline	alkaline	JJ
cord-015021-pol2qm74	6030	3	gastric	gastric	NN
cord-015021-pol2qm74	6030	4	pH	ph	NN
cord-015021-pol2qm74	6030	5	is	be	VBZ
cord-015021-pol2qm74	6030	6	protective	protective	JJ
cord-015021-pol2qm74	6030	7	against	against	IN
cord-015021-pol2qm74	6030	8	stress	stress	NN
cord-015021-pol2qm74	6030	9	ulcers	ulcer	NNS
cord-015021-pol2qm74	6030	10	.	.	.
cord-015021-pol2qm74	6031	1	Omeprazole	omeprazole	NN
cord-015021-pol2qm74	6031	2	when	when	WRB
cord-015021-pol2qm74	6031	3	used	use	VBN
cord-015021-pol2qm74	6031	4	for	for	IN
cord-015021-pol2qm74	6031	5	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	6031	6	against	against	IN
cord-015021-pol2qm74	6031	7	stress	stress	NN
cord-015021-pol2qm74	6031	8	ulcers	ulcer	NNS
cord-015021-pol2qm74	6031	9	in	in	IN
cord-015021-pol2qm74	6031	10	critically	critically	RB
cord-015021-pol2qm74	6031	11	ill	ill	JJ
cord-015021-pol2qm74	6031	12	patients	patient	NNS
cord-015021-pol2qm74	6031	13	or	or	CC
cord-015021-pol2qm74	6031	14	those	those	DT
cord-015021-pol2qm74	6031	15	on	on	IN
cord-015021-pol2qm74	6031	16	short	short	JJ
cord-015021-pol2qm74	6031	17	term	term	NN
cord-015021-pol2qm74	6031	18	ventilation	ventilation	NN
cord-015021-pol2qm74	6031	19	will	will	MD
cord-015021-pol2qm74	6031	20	reduce	reduce	VB
cord-015021-pol2qm74	6031	21	the	the	DT
cord-015021-pol2qm74	6031	22	incidence	incidence	NN
cord-015021-pol2qm74	6031	23	of	of	IN
cord-015021-pol2qm74	6031	24	formation	formation	NN
cord-015021-pol2qm74	6031	25	and	and	CC
cord-015021-pol2qm74	6031	26	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6031	27	from	from	IN
cord-015021-pol2qm74	6031	28	stress	stress	NN
cord-015021-pol2qm74	6031	29	ulcers	ulcer	NNS
cord-015021-pol2qm74	6031	30	.	.	.
cord-015021-pol2qm74	6032	1	The	the	DT
cord-015021-pol2qm74	6032	2	early	early	JJ
cord-015021-pol2qm74	6032	3	and	and	CC
cord-015021-pol2qm74	6032	4	accurate	accurate	JJ
cord-015021-pol2qm74	6032	5	diagnosis	diagnosis	NN
cord-015021-pol2qm74	6032	6	of	of	IN
cord-015021-pol2qm74	6032	7	sepsis	sepsis	NN
cord-015021-pol2qm74	6032	8	is	be	VBZ
cord-015021-pol2qm74	6032	9	of	of	IN
cord-015021-pol2qm74	6032	10	key	key	JJ
cord-015021-pol2qm74	6032	11	importance	importance	NN
cord-015021-pol2qm74	6032	12	for	for	IN
cord-015021-pol2qm74	6032	13	critically	critically	RB
cord-015021-pol2qm74	6032	14	ill	ill	JJ
cord-015021-pol2qm74	6032	15	patients	patient	NNS
cord-015021-pol2qm74	6032	16	survival	survival	NN
cord-015021-pol2qm74	6032	17	.	.	.
cord-015021-pol2qm74	6033	1	Many	many	JJ
cord-015021-pol2qm74	6033	2	studies	study	NNS
cord-015021-pol2qm74	6033	3	have	have	VBP
cord-015021-pol2qm74	6033	4	shown	show	VBN
cord-015021-pol2qm74	6033	5	that	that	IN
cord-015021-pol2qm74	6033	6	tumor	tumor	NN
cord-015021-pol2qm74	6033	7	necrosis	necrosis	NN
cord-015021-pol2qm74	6033	8	factor	factor	NN
cord-015021-pol2qm74	6034	1	~x	~x	NNP
cord-015021-pol2qm74	6035	1	(	(	-LRB-
cord-015021-pol2qm74	6035	2	TNF	TNF	NNP
cord-015021-pol2qm74	6035	3	~	~	NFP
cord-015021-pol2qm74	6035	4	)	)	-RRB-
cord-015021-pol2qm74	6035	5	and	and	CC
cord-015021-pol2qm74	6035	6	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	6035	7	(	(	-LRB-
cord-015021-pol2qm74	6035	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	6035	9	)	)	-RRB-
cord-015021-pol2qm74	6035	10	are	be	VBP
cord-015021-pol2qm74	6035	11	mediators	mediator	NNS
cord-015021-pol2qm74	6035	12	of	of	IN
cord-015021-pol2qm74	6035	13	the	the	DT
cord-015021-pol2qm74	6035	14	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6035	15	response	response	NN
cord-015021-pol2qm74	6035	16	in	in	IN
cord-015021-pol2qm74	6035	17	sepsis	sepsis	NN
cord-015021-pol2qm74	6035	18	.	.	.
cord-015021-pol2qm74	6036	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	6036	2	antigens	antigen	NNS
cord-015021-pol2qm74	6036	3	interact	interact	VBP
cord-015021-pol2qm74	6036	4	also	also	RB
cord-015021-pol2qm74	6036	5	with	with	IN
cord-015021-pol2qm74	6036	6	antigen	antigen	NN
cord-015021-pol2qm74	6036	7	specific	specific	JJ
cord-015021-pol2qm74	6036	8	T	T	NNP
cord-015021-pol2qm74	6036	9	cell	cell	NN
cord-015021-pol2qm74	6036	10	receptors	receptor	NNS
cord-015021-pol2qm74	6036	11	and	and	CC
cord-015021-pol2qm74	6036	12	the	the	DT
cord-015021-pol2qm74	6036	13	activation	activation	NN
cord-015021-pol2qm74	6036	14	of	of	IN
cord-015021-pol2qm74	6036	15	T	T	NNP
cord-015021-pol2qm74	6036	16	ceils	ceils	NNP
cord-015021-pol2qm74	6036	17	takes	take	VBZ
cord-015021-pol2qm74	6036	18	place	place	NN
cord-015021-pol2qm74	6036	19	.	.	.
cord-015021-pol2qm74	6037	1	Activated	activate	VBN
cord-015021-pol2qm74	6037	2	T	T	NNP
cord-015021-pol2qm74	6037	3	cells	cell	NNS
cord-015021-pol2qm74	6037	4	release	release	VBP
cord-015021-pol2qm74	6037	5	soluble	soluble	JJ
cord-015021-pol2qm74	6037	6	interteuldn-2	interteuldn-2	NNP
cord-015021-pol2qm74	6037	7	receptors	receptor	NNS
cord-015021-pol2qm74	6037	8	(	(	-LRB-
cord-015021-pol2qm74	6037	9	sIL-2R	sIL-2R	NNP
cord-015021-pol2qm74	6037	10	)	)	-RRB-
cord-015021-pol2qm74	6037	11	.	.	.
cord-015021-pol2qm74	6038	1	The	the	DT
cord-015021-pol2qm74	6038	2	aim	aim	NN
cord-015021-pol2qm74	6038	3	of	of	IN
cord-015021-pol2qm74	6038	4	this	this	DT
cord-015021-pol2qm74	6038	5	study	study	NN
cord-015021-pol2qm74	6038	6	was	be	VBD
cord-015021-pol2qm74	6038	7	to	to	TO
cord-015021-pol2qm74	6038	8	evaluate	evaluate	VB
cord-015021-pol2qm74	6038	9	:	:	:
cord-015021-pol2qm74	6038	10	the	the	DT
cord-015021-pol2qm74	6038	11	significance	significance	NN
cord-015021-pol2qm74	6038	12	ofTNF	oftnf	IN
cord-015021-pol2qm74	6039	1	c~	c~	XX
cord-015021-pol2qm74	6039	2	,	,	,
cord-015021-pol2qm74	6039	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	6039	4	and	and	CC
cord-015021-pol2qm74	6039	5	slL-2R	slL-2R	NNP
cord-015021-pol2qm74	6039	6	in	in	IN
cord-015021-pol2qm74	6039	7	the	the	DT
cord-015021-pol2qm74	6039	8	diagnosis	diagnosis	NN
cord-015021-pol2qm74	6039	9	of	of	IN
cord-015021-pol2qm74	6039	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	6039	11	sepsis	sepsis	NN
cord-015021-pol2qm74	6039	12	and	and	CC
cord-015021-pol2qm74	6039	13	to	to	TO
cord-015021-pol2qm74	6039	14	evaluate	evaluate	VB
cord-015021-pol2qm74	6039	15	the	the	DT
cord-015021-pol2qm74	6039	16	correlation	correlation	NN
cord-015021-pol2qm74	6039	17	of	of	IN
cord-015021-pol2qm74	6039	18	clinical	clinical	JJ
cord-015021-pol2qm74	6039	19	and	and	CC
cord-015021-pol2qm74	6039	20	laboratory	laboratory	NN
cord-015021-pol2qm74	6039	21	parameters	parameter	NNS
cord-015021-pol2qm74	6039	22	with	with	IN
cord-015021-pol2qm74	6039	23	serum	serum	NN
cord-015021-pol2qm74	6039	24	levels	level	NNS
cord-015021-pol2qm74	6039	25	of	of	IN
cord-015021-pol2qm74	6039	26	TNF	TNF	NNP
cord-015021-pol2qm74	6039	27	~x	~x	NNP
cord-015021-pol2qm74	6039	28	,	,	,
cord-015021-pol2qm74	6039	29	IL-6	IL-6	NNP
cord-015021-pol2qm74	6039	30	and	and	CC
cord-015021-pol2qm74	6039	31	slL-2R.	slL-2R.	NNP
cord-015021-pol2qm74	6040	1	We	-PRON-	PRP
cord-015021-pol2qm74	6040	2	examined	examine	VBD
cord-015021-pol2qm74	6040	3	19	19	CD
cord-015021-pol2qm74	6040	4	patients	patient	NNS
cord-015021-pol2qm74	6040	5	with	with	IN
cord-015021-pol2qm74	6040	6	clinical	clinical	JJ
cord-015021-pol2qm74	6040	7	signs	sign	NNS
cord-015021-pol2qm74	6040	8	of	of	IN
cord-015021-pol2qm74	6040	9	sepsis	sepsis	NN
cord-015021-pol2qm74	6040	10	treated	treat	VBN
cord-015021-pol2qm74	6040	11	in	in	IN
cord-015021-pol2qm74	6040	12	the	the	DT
cord-015021-pol2qm74	6040	13	intensive	intensive	JJ
cord-015021-pol2qm74	6040	14	care	care	NN
cord-015021-pol2qm74	6040	15	units	unit	NNS
cord-015021-pol2qm74	6040	16	of	of	IN
cord-015021-pol2qm74	6040	17	University	University	NNP
cord-015021-pol2qm74	6040	18	Medical	Medical	NNP
cord-015021-pol2qm74	6040	19	Centre	Centre	NNP
cord-015021-pol2qm74	6040	20	Ljubljana	Ljubljana	NNP
cord-015021-pol2qm74	6040	21	.	.	.
cord-015021-pol2qm74	6041	1	Venous	venous	JJ
cord-015021-pol2qm74	6041	2	blood	blood	NN
cord-015021-pol2qm74	6041	3	was	be	VBD
cord-015021-pol2qm74	6041	4	drawn	draw	VBN
cord-015021-pol2qm74	6041	5	from	from	IN
cord-015021-pol2qm74	6041	6	each	each	DT
cord-015021-pol2qm74	6041	7	patient	patient	NN
cord-015021-pol2qm74	6041	8	within	within	IN
cord-015021-pol2qm74	6041	9	24	24	CD
cord-015021-pol2qm74	6041	10	hours	hour	NNS
cord-015021-pol2qm74	6041	11	after	after	IN
cord-015021-pol2qm74	6041	12	the	the	DT
cord-015021-pol2qm74	6041	13	first	first	JJ
cord-015021-pol2qm74	6041	14	clinical	clinical	JJ
cord-015021-pol2qm74	6041	15	signs	sign	NNS
cord-015021-pol2qm74	6041	16	of	of	IN
cord-015021-pol2qm74	6041	17	sepsis	sepsis	NN
cord-015021-pol2qm74	6041	18	.	.	.
cord-015021-pol2qm74	6042	1	Clinical	clinical	JJ
cord-015021-pol2qm74	6042	2	data	datum	NNS
cord-015021-pol2qm74	6042	3	(	(	-LRB-
cord-015021-pol2qm74	6042	4	body	body	NN
cord-015021-pol2qm74	6042	5	temperature	temperature	NN
cord-015021-pol2qm74	6042	6	,	,	,
cord-015021-pol2qm74	6042	7	blood	blood	NN
cord-015021-pol2qm74	6042	8	pressure	pressure	NN
cord-015021-pol2qm74	6042	9	)	)	-RRB-
cord-015021-pol2qm74	6042	10	,	,	,
cord-015021-pol2qm74	6042	11	laboratory	laboratory	NN
cord-015021-pol2qm74	6042	12	dam	dam	NN
cord-015021-pol2qm74	6042	13	(	(	-LRB-
cord-015021-pol2qm74	6042	14	peripheral	peripheral	JJ
cord-015021-pol2qm74	6042	15	white	white	JJ
cord-015021-pol2qm74	6042	16	blood	blood	NN
cord-015021-pol2qm74	6042	17	cell	cell	NN
cord-015021-pol2qm74	6042	18	count	count	NN
cord-015021-pol2qm74	6042	19	with	with	IN
cord-015021-pol2qm74	6042	20	differential	differential	JJ
cord-015021-pol2qm74	6042	21	,	,	,
cord-015021-pol2qm74	6042	22	platelet	platelet	NN
cord-015021-pol2qm74	6042	23	count	count	NN
cord-015021-pol2qm74	6042	24	,	,	,
cord-015021-pol2qm74	6042	25	C	c	NN
cord-015021-pol2qm74	6042	26	-	-	HYPH
cord-015021-pol2qm74	6042	27	reactive	reactive	JJ
cord-015021-pol2qm74	6042	28	protein	protein	NN
cord-015021-pol2qm74	6042	29	)	)	-RRB-
cord-015021-pol2qm74	6042	30	,	,	,
cord-015021-pol2qm74	6042	31	and	and	CC
cord-015021-pol2qm74	6042	32	quantitative	quantitative	JJ
cord-015021-pol2qm74	6042	33	blood	blood	NN
cord-015021-pol2qm74	6042	34	cultures	culture	NNS
cord-015021-pol2qm74	6042	35	were	be	VBD
cord-015021-pol2qm74	6042	36	recorded	record	VBN
cord-015021-pol2qm74	6042	37	.	.	.
cord-015021-pol2qm74	6043	1	Serum	serum	NN
cord-015021-pol2qm74	6043	2	levels	level	NNS
cord-015021-pol2qm74	6043	3	of	of	IN
cord-015021-pol2qm74	6043	4	TNF	TNF	NNP
cord-015021-pol2qm74	6044	1	c~	c~	XX
cord-015021-pol2qm74	6044	2	,	,	,
cord-015021-pol2qm74	6045	1	11,-6	11,-6	NNP
cord-015021-pol2qm74	6045	2	and	and	CC
cord-015021-pol2qm74	6045	3	sIL-2R	sIL-2R	NNP
cord-015021-pol2qm74	6045	4	were	be	VBD
cord-015021-pol2qm74	6045	5	measured	measure	VBN
cord-015021-pol2qm74	6045	6	in	in	IN
cord-015021-pol2qm74	6045	7	19	19	CD
cord-015021-pol2qm74	6045	8	septic	septic	JJ
cord-015021-pol2qm74	6045	9	patients	patient	NNS
cord-015021-pol2qm74	6045	10	and	and	CC
cord-015021-pol2qm74	6045	11	in	in	IN
cord-015021-pol2qm74	6045	12	20	20	CD
cord-015021-pol2qm74	6045	13	adult	adult	NN
cord-015021-pol2qm74	6045	14	healthy	healthy	JJ
cord-015021-pol2qm74	6045	15	controls	control	NNS
cord-015021-pol2qm74	6045	16	.	.	.
cord-015021-pol2qm74	6046	1	TNF	TNF	NNP
cord-015021-pol2qm74	6046	2	ct	ct	NNP
cord-015021-pol2qm74	6046	3	,	,	,
cord-015021-pol2qm74	6046	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	6046	5	and	and	CC
cord-015021-pol2qm74	6046	6	sIL-2R	sIL-2R	NNP
cord-015021-pol2qm74	6046	7	serum	serum	NN
cord-015021-pol2qm74	6046	8	levels	level	NNS
cord-015021-pol2qm74	6046	9	were	be	VBD
cord-015021-pol2qm74	6046	10	measured	measure	VBN
cord-015021-pol2qm74	6046	11	by	by	IN
cord-015021-pol2qm74	6046	12	commercially	commercially	RB
cord-015021-pol2qm74	6046	13	available	available	JJ
cord-015021-pol2qm74	6046	14	RIA	RIA	NNP
cord-015021-pol2qm74	6046	15	and	and	CC
cord-015021-pol2qm74	6046	16	ELISA	ELISA	NNP
cord-015021-pol2qm74	6047	1	(	(	-LRB-
cord-015021-pol2qm74	6047	2	Amersharn	Amersharn	NNP
cord-015021-pol2qm74	6047	3	and	and	CC
cord-015021-pol2qm74	6047	4	Eurogenetics	Eurogenetics	NNP
cord-015021-pol2qm74	6047	5	)	)	-RRB-
cord-015021-pol2qm74	6047	6	kits	kit	NNS
cord-015021-pol2qm74	6047	7	.	.	.
cord-015021-pol2qm74	6048	1	The	the	DT
cord-015021-pol2qm74	6048	2	differences	difference	NNS
cord-015021-pol2qm74	6048	3	in	in	IN
cord-015021-pol2qm74	6048	4	serttm	serttm	NN
cord-015021-pol2qm74	6048	5	levels	level	NNS
cord-015021-pol2qm74	6048	6	of	of	IN
cord-015021-pol2qm74	6048	7	TNF	TNF	NNP
cord-015021-pol2qm74	6048	8	~	~	NFP
cord-015021-pol2qm74	6048	9	,	,	,
cord-015021-pol2qm74	6048	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	6048	11	and	and	CC
cord-015021-pol2qm74	6048	12	sIL-2R	sIL-2R	NNS
cord-015021-pol2qm74	6048	13	between	between	IN
cord-015021-pol2qm74	6048	14	healthy	healthy	JJ
cord-015021-pol2qm74	6048	15	control	control	NN
cord-015021-pol2qm74	6048	16	and	and	CC
cord-015021-pol2qm74	6048	17	patients	patient	NNS
cord-015021-pol2qm74	6048	18	and	and	CC
cord-015021-pol2qm74	6048	19	correlation	correlation	NN
cord-015021-pol2qm74	6048	20	between	between	IN
cord-015021-pol2qm74	6048	21	clinical	clinical	JJ
cord-015021-pol2qm74	6048	22	and	and	CC
cord-015021-pol2qm74	6048	23	laboratory	laboratory	NN
cord-015021-pol2qm74	6048	24	parameters	parameter	NNS
cord-015021-pol2qm74	6048	25	were	be	VBD
cord-015021-pol2qm74	6048	26	calculated	calculate	VBN
cord-015021-pol2qm74	6048	27	.	.	.
cord-015021-pol2qm74	6049	1	We	-PRON-	PRP
cord-015021-pol2qm74	6049	2	found	find	VBD
cord-015021-pol2qm74	6049	3	that	that	IN
cord-015021-pol2qm74	6049	4	only	only	RB
cord-015021-pol2qm74	6049	5	slL-2R	sll-2r	JJ
cord-015021-pol2qm74	6049	6	serum	serum	NN
cord-015021-pol2qm74	6049	7	levels	level	NNS
cord-015021-pol2qm74	6049	8	were	be	VBD
cord-015021-pol2qm74	6049	9	significantly	significantly	RB
cord-015021-pol2qm74	6049	10	(	(	-LRB-
cord-015021-pol2qm74	6049	11	p<0.005	p<0.005	JJ
cord-015021-pol2qm74	6049	12	,	,	,
cord-015021-pol2qm74	6049	13	Student	Student	NNP
cord-015021-pol2qm74	6049	14	t	t	NN
cord-015021-pol2qm74	6049	15	test	test	NN
cord-015021-pol2qm74	6049	16	)	)	-RRB-
cord-015021-pol2qm74	6049	17	increased	increase	VBD
cord-015021-pol2qm74	6049	18	in	in	IN
cord-015021-pol2qm74	6049	19	patients	patient	NNS
cord-015021-pol2qm74	6049	20	in	in	IN
cord-015021-pol2qm74	6049	21	comparison	comparison	NN
cord-015021-pol2qm74	6049	22	with	with	IN
cord-015021-pol2qm74	6049	23	healthy	healthy	JJ
cord-015021-pol2qm74	6049	24	controls	control	NNS
cord-015021-pol2qm74	6049	25	.	.	.
cord-015021-pol2qm74	6050	1	Of	of	IN
cord-015021-pol2qm74	6050	2	all	all	DT
cord-015021-pol2qm74	6050	3	indicators	indicator	NNS
cord-015021-pol2qm74	6050	4	of	of	IN
cord-015021-pol2qm74	6050	5	sepsis	sepsis	NN
cord-015021-pol2qm74	6050	6	that	that	WDT
cord-015021-pol2qm74	6050	7	we	-PRON-	PRP
cord-015021-pol2qm74	6050	8	compared	compare	VBD
cord-015021-pol2qm74	6050	9	,	,	,
cord-015021-pol2qm74	6050	10	only	only	JJ
cord-015021-pol2qm74	6050	11	hypotension	hypotension	NN
cord-015021-pol2qm74	6050	12	was	be	VBD
cord-015021-pol2qm74	6050	13	significantly	significantly	RB
cord-015021-pol2qm74	6050	14	correlated	correlate	VBN
cord-015021-pol2qm74	6050	15	with	with	IN
cord-015021-pol2qm74	6050	16	TNF	TNF	NNP
cord-015021-pol2qm74	6050	17	~x	~x	NNP
cord-015021-pol2qm74	6050	18	levels	level	NNS
cord-015021-pol2qm74	6050	19	and	and	CC
cord-015021-pol2qm74	6050	20	leukocytosis	leukocytosis	NN
cord-015021-pol2qm74	6050	21	with	with	IN
cord-015021-pol2qm74	6050	22	]	]	-RRB-
cord-015021-pol2qm74	6050	23	1,-6	1,-6	CD
cord-015021-pol2qm74	6050	24	levels	level	NNS
cord-015021-pol2qm74	6050	25	.	.	.
cord-015021-pol2qm74	6051	1	We	-PRON-	PRP
cord-015021-pol2qm74	6051	2	conclude	conclude	VBP
cord-015021-pol2qm74	6051	3	that	that	IN
cord-015021-pol2qm74	6051	4	only	only	RB
cord-015021-pol2qm74	6051	5	the	the	DT
cord-015021-pol2qm74	6051	6	increased	increase	VBN
cord-015021-pol2qm74	6051	7	serum	serum	NN
cord-015021-pol2qm74	6051	8	sIL-2R	sil-2r	NN
cord-015021-pol2qm74	6051	9	levels	level	NNS
cord-015021-pol2qm74	6051	10	were	be	VBD
cord-015021-pol2qm74	6051	11	predictive	predictive	JJ
cord-015021-pol2qm74	6051	12	of	of	IN
cord-015021-pol2qm74	6051	13	bacterial	bacterial	JJ
cord-015021-pol2qm74	6051	14	sepsis	sepsis	NN
cord-015021-pol2qm74	6051	15	within	within	IN
cord-015021-pol2qm74	6051	16	24	24	CD
cord-015021-pol2qm74	6051	17	hours	hour	NNS
cord-015021-pol2qm74	6051	18	after	after	IN
cord-015021-pol2qm74	6051	19	the	the	DT
cord-015021-pol2qm74	6051	20	first	first	JJ
cord-015021-pol2qm74	6051	21	septic	septic	JJ
cord-015021-pol2qm74	6051	22	signs	sign	NNS
cord-015021-pol2qm74	6051	23	.	.	.
cord-015021-pol2qm74	6052	1	TNF	TNF	NNP
cord-015021-pol2qm74	6052	2	c~	c~	NNP
cord-015021-pol2qm74	6052	3	and	and	CC
cord-015021-pol2qm74	6052	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	6052	5	levels	level	NNS
cord-015021-pol2qm74	6052	6	were	be	VBD
cord-015021-pol2qm74	6052	7	not	not	RB
cord-015021-pol2qm74	6052	8	significantly	significantly	RB
cord-015021-pol2qm74	6052	9	increased	increase	VBN
cord-015021-pol2qm74	6052	10	at	at	IN
cord-015021-pol2qm74	6052	11	that	that	DT
cord-015021-pol2qm74	6052	12	time	time	NN
cord-015021-pol2qm74	6052	13	in	in	IN
cord-015021-pol2qm74	6052	14	lifts	lift	VBZ
cord-015021-pol2qm74	6052	15	small	small	JJ
cord-015021-pol2qm74	6052	16	group	group	NN
cord-015021-pol2qm74	6052	17	of	of	IN
cord-015021-pol2qm74	6052	18	patients	patient	NNS
cord-015021-pol2qm74	6052	19	.	.	.
cord-015021-pol2qm74	6053	1	In	in	IN
cord-015021-pol2qm74	6053	2	order	order	NN
cord-015021-pol2qm74	6053	3	to	to	TO
cord-015021-pol2qm74	6053	4	create	create	VB
cord-015021-pol2qm74	6053	5	high	high	JJ
cord-015021-pol2qm74	6053	6	precision	precision	NN
cord-015021-pol2qm74	6053	7	prognostic	prognostic	JJ
cord-015021-pol2qm74	6053	8	system	system	NN
cord-015021-pol2qm74	6053	9	for	for	IN
cord-015021-pol2qm74	6053	10	patients	patient	NNS
cord-015021-pol2qm74	6053	11	with	with	IN
cord-015021-pol2qm74	6053	12	sepsis	sepsis	NN
cord-015021-pol2qm74	6053	13	and	and	CC
cord-015021-pol2qm74	6053	14	septic	septic	JJ
cord-015021-pol2qm74	6053	15	shock	shock	NN
cord-015021-pol2qm74	6053	16	we	-PRON-	PRP
cord-015021-pol2qm74	6053	17	have	have	VBP
cord-015021-pol2qm74	6053	18	made	make	VBN
cord-015021-pol2qm74	6053	19	prospective	prospective	JJ
cord-015021-pol2qm74	6053	20	and	and	CC
cord-015021-pol2qm74	6053	21	retrospective	retrospective	JJ
cord-015021-pol2qm74	6053	22	analis	anali	NNS
cord-015021-pol2qm74	6053	23	of	of	IN
cord-015021-pol2qm74	6053	24	200	200	CD
cord-015021-pol2qm74	6053	25	cases	case	NNS
cord-015021-pol2qm74	6053	26	of	of	IN
cord-015021-pol2qm74	6053	27	sepsis	sepsis	NN
cord-015021-pol2qm74	6053	28	.	.	.
cord-015021-pol2qm74	6054	1	Patients	patient	NNS
cord-015021-pol2qm74	6054	2	were	be	VBD
cord-015021-pol2qm74	6054	3	included	include	VBN
cord-015021-pol2qm74	6054	4	in	in	IN
cord-015021-pol2qm74	6054	5	this	this	DT
cord-015021-pol2qm74	6054	6	analis	anali	NNS
cord-015021-pol2qm74	6054	7	according	accord	VBG
cord-015021-pol2qm74	6054	8	Bone	Bone	NNP
cord-015021-pol2qm74	6054	9	's	's	POS
cord-015021-pol2qm74	6054	10	criterions	criterion	NNS
cord-015021-pol2qm74	6054	11	of	of	IN
cord-015021-pol2qm74	6054	12	sepsis	sepsis	NN
cord-015021-pol2qm74	6054	13	.	.	.
cord-015021-pol2qm74	6055	1	Comparing	compare	VBG
cord-015021-pol2qm74	6055	2	with	with	IN
cord-015021-pol2qm74	6055	3	APACHE	APACHE	NNP
cord-015021-pol2qm74	6055	4	-	-	HYPH
cord-015021-pol2qm74	6055	5	H	H	NNP
cord-015021-pol2qm74	6055	6	,	,	,
cord-015021-pol2qm74	6055	7	we	-PRON-	PRP
cord-015021-pol2qm74	6055	8	have	have	VBP
cord-015021-pol2qm74	6055	9	excluded	exclude	VBN
cord-015021-pol2qm74	6055	10	such	such	JJ
cord-015021-pol2qm74	6055	11	phisiologic	phisiologic	JJ
cord-015021-pol2qm74	6055	12	variables	variable	NNS
cord-015021-pol2qm74	6055	13	as	as	IN
cord-015021-pol2qm74	6055	14	:	:	:
cord-015021-pol2qm74	6055	15	temperature	temperature	NN
cord-015021-pol2qm74	6055	16	,	,	,
cord-015021-pol2qm74	6055	17	Na+	na+	NN
cord-015021-pol2qm74	6055	18	,	,	,
cord-015021-pol2qm74	6055	19	K+	K+	NNP
cord-015021-pol2qm74	6055	20	,	,	,
cord-015021-pol2qm74	6055	21	}	}	-RRB-
cord-015021-pol2qm74	6055	22	It	-PRON-	PRP
cord-015021-pol2qm74	6055	23	,	,	,
cord-015021-pol2qm74	6055	24	pH	pH	NNP
cord-015021-pol2qm74	6055	25	,	,	,
cord-015021-pol2qm74	6055	26	which	which	WDT
cord-015021-pol2qm74	6055	27	had	have	VBD
cord-015021-pol2qm74	6055	28	a	a	DT
cord-015021-pol2qm74	6055	29	little	little	JJ
cord-015021-pol2qm74	6055	30	influence	influence	NN
cord-015021-pol2qm74	6055	31	on	on	IN
cord-015021-pol2qm74	6055	32	prognos	prognos	NNP
cord-015021-pol2qm74	6055	33	of	of	IN
cord-015021-pol2qm74	6055	34	illness	illness	NN
cord-015021-pol2qm74	6055	35	.	.	.
cord-015021-pol2qm74	6056	1	We	-PRON-	PRP
cord-015021-pol2qm74	6056	2	have	have	VBP
cord-015021-pol2qm74	6056	3	added	add	VBN
cord-015021-pol2qm74	6056	4	the	the	DT
cord-015021-pol2qm74	6056	5	other	other	JJ
cord-015021-pol2qm74	6056	6	,	,	,
cord-015021-pol2qm74	6056	7	more	more	RBR
cord-015021-pol2qm74	6056	8	important	important	JJ
cord-015021-pol2qm74	6056	9	variables	variable	NNS
cord-015021-pol2qm74	6056	10	:	:	:
cord-015021-pol2qm74	6056	11	biilirubin	biilirubin	NNP
cord-015021-pol2qm74	6056	12	,	,	,
cord-015021-pol2qm74	6056	13	plateles	platele	NNS
cord-015021-pol2qm74	6056	14	,	,	,
cord-015021-pol2qm74	6056	15	PTI	PTI	NNP
cord-015021-pol2qm74	6056	16	.	.	.
cord-015021-pol2qm74	6057	1	We	-PRON-	PRP
cord-015021-pol2qm74	6057	2	took	take	VBD
cord-015021-pol2qm74	6057	3	into	into	IN
cord-015021-pol2qm74	6057	4	account	account	NN
cord-015021-pol2qm74	6057	5	:	:	:
cord-015021-pol2qm74	6057	6	the	the	DT
cord-015021-pol2qm74	6057	7	seat	seat	NN
cord-015021-pol2qm74	6057	8	arrangement	arrangement	NN
cord-015021-pol2qm74	6057	9	,	,	,
cord-015021-pol2qm74	6057	10	methods	method	NNS
cord-015021-pol2qm74	6057	11	of	of	IN
cord-015021-pol2qm74	6057	12	respiratory	respiratory	JJ
cord-015021-pol2qm74	6057	13	support	support	NN
cord-015021-pol2qm74	6057	14	,	,	,
cord-015021-pol2qm74	6057	15	comorbid	comorbid	NN
cord-015021-pol2qm74	6057	16	conditions	condition	NNS
cord-015021-pol2qm74	6057	17	as	as	IN
cord-015021-pol2qm74	6057	18	:	:	:
cord-015021-pol2qm74	6057	19	caneer	caneer	NNP
cord-015021-pol2qm74	6057	20	,	,	,
cord-015021-pol2qm74	6057	21	diabets	diabets	NNPS
cord-015021-pol2qm74	6057	22	,	,	,
cord-015021-pol2qm74	6057	23	obersity	obersity	NN
cord-015021-pol2qm74	6057	24	.	.	.
cord-015021-pol2qm74	6058	1	In	in	IN
cord-015021-pol2qm74	6058	2	general	general	JJ
cord-015021-pol2qm74	6058	3	new	new	JJ
cord-015021-pol2qm74	6058	4	score	score	NN
cord-015021-pol2qm74	6058	5	has	have	VBZ
cord-015021-pol2qm74	6058	6	5	5	CD
cord-015021-pol2qm74	6058	7	headings	heading	NNS
cord-015021-pol2qm74	6058	8	:	:	:
cord-015021-pol2qm74	6058	9	-physiologic	-physiologic	NN
cord-015021-pol2qm74	6058	10	variables	variable	NNS
cord-015021-pol2qm74	6058	11	,	,	,
cord-015021-pol2qm74	6058	12	-age	-age	''
cord-015021-pol2qm74	6058	13	,	,	,
cord-015021-pol2qm74	6058	14	-seat	-seat	CD
cord-015021-pol2qm74	6058	15	arrangement	arrangement	NN
cord-015021-pol2qm74	6058	16	,	,	,
cord-015021-pol2qm74	6058	17	-chronic	-chronic	:
cord-015021-pol2qm74	6058	18	comorbid	comorbid	NN
cord-015021-pol2qm74	6058	19	conditions	condition	NNS
cord-015021-pol2qm74	6058	20	,	,	,
cord-015021-pol2qm74	6058	21	-methods	-methods	RB
cord-015021-pol2qm74	6058	22	of	of	IN
cord-015021-pol2qm74	6058	23	respiratory	respiratory	JJ
cord-015021-pol2qm74	6058	24	support	support	NN
cord-015021-pol2qm74	6058	25	.	.	.
cord-015021-pol2qm74	6059	1	ROC	ROC	NNP
cord-015021-pol2qm74	6059	2	-analis	-anali	NNS
cord-015021-pol2qm74	6059	3	have	have	VBP
cord-015021-pol2qm74	6059	4	showed	show	VBN
cord-015021-pol2qm74	6059	5	a	a	DT
cord-015021-pol2qm74	6059	6	greater	great	JJR
cord-015021-pol2qm74	6059	7	precision	precision	NN
cord-015021-pol2qm74	6059	8	of	of	IN
cord-015021-pol2qm74	6059	9	our	-PRON-	PRP$
cord-015021-pol2qm74	6059	10	score	score	NN
cord-015021-pol2qm74	6059	11	,	,	,
cord-015021-pol2qm74	6059	12	compared	compare	VBN
cord-015021-pol2qm74	6059	13	with	with	IN
cord-015021-pol2qm74	6059	14	APACHE	APACHE	NNP
cord-015021-pol2qm74	6059	15	-	-	HYPH
cord-015021-pol2qm74	6059	16	II	II	NNP
cord-015021-pol2qm74	6059	17	score	score	NN
cord-015021-pol2qm74	6059	18	.	.	.
cord-015021-pol2qm74	6060	1	There	there	EX
cord-015021-pol2qm74	6060	2	is	be	VBZ
cord-015021-pol2qm74	6060	3	significant	significant	JJ
cord-015021-pol2qm74	6060	4	difference	difference	NN
cord-015021-pol2qm74	6060	5	between	between	IN
cord-015021-pol2qm74	6060	6	the	the	DT
cord-015021-pol2qm74	6060	7	ROC	ROC	NNP
cord-015021-pol2qm74	6060	8	-	-	HYPH
cord-015021-pol2qm74	6060	9	curve	curve	NN
cord-015021-pol2qm74	6060	10	of	of	IN
cord-015021-pol2qm74	6060	11	APACHE	APACHE	NNP
cord-015021-pol2qm74	6060	12	-	-	HYPH
cord-015021-pol2qm74	6060	13	II	II	NNP
cord-015021-pol2qm74	6060	14	scare	scare	NN
cord-015021-pol2qm74	6060	15	.	.	.
cord-015021-pol2qm74	6061	1	The	the	DT
cord-015021-pol2qm74	6061	2	k.	k.	NNP
cord-015021-pol2qm74	6062	1	P.Tit	P.Tit	NNP
cord-015021-pol2qm74	6063	1	~v	~v	NNP
cord-015021-pol2qm74	6063	2	.	.	.
cord-015021-pol2qm74	6063	3	,I.E.Gurmanchuk	,I.E.Gurmanchuk	NFP
cord-015021-pol2qm74	6063	4	.	.	.
cord-015021-pol2qm74	6064	1	Objectives	objective	NNS
cord-015021-pol2qm74	6064	2	of	of	IN
cord-015021-pol2qm74	6064	3	the	the	DT
cord-015021-pol2qm74	6064	4	study	study	NN
cord-015021-pol2qm74	6064	5	.	.	.
cord-015021-pol2qm74	6065	1	Sepsis	sepsis	NN
cord-015021-pol2qm74	6065	2	is	be	VBZ
cord-015021-pol2qm74	6065	3	a	a	DT
cord-015021-pol2qm74	6065	4	severe	severe	JJ
cord-015021-pol2qm74	6065	5	complication	complication	NN
cord-015021-pol2qm74	6065	6	of	of	IN
cord-015021-pol2qm74	6065	7	the	the	DT
cord-015021-pol2qm74	6065	8	local	local	JJ
cord-015021-pol2qm74	6065	9	infection	infection	NN
cord-015021-pol2qm74	6065	10	,	,	,
cord-015021-pol2qm74	6065	11	Th	Th	NNP
cord-015021-pol2qm74	6065	12	e	e	NN
cord-015021-pol2qm74	6065	13	fever	fever	NN
cord-015021-pol2qm74	6065	14	and	and	CC
cord-015021-pol2qm74	6065	15	the	the	DT
cord-015021-pol2qm74	6065	16	systemic	systemic	JJ
cord-015021-pol2qm74	6065	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6065	18	response	response	NN
cord-015021-pol2qm74	6065	19	syndrome	syndrome	NN
cord-015021-pol2qm74	6065	20	may	may	MD
cord-015021-pol2qm74	6065	21	take	take	VB
cord-015021-pol2qm74	6065	22	place	place	NN
cord-015021-pol2qm74	6065	23	in	in	IN
cord-015021-pol2qm74	6065	24	such	such	PDT
cord-015021-pol2qm74	6065	25	a	a	DT
cord-015021-pol2qm74	6065	26	case	case	NN
cord-015021-pol2qm74	6065	27	as	as	IN
cord-015021-pol2qm74	6065	28	manifistations	manifistation	NNS
cord-015021-pol2qm74	6065	29	of	of	IN
cord-015021-pol2qm74	6065	30	the	the	DT
cord-015021-pol2qm74	6065	31	inflammation	inflammation	NN
cord-015021-pol2qm74	6065	32	induced	induce	VBN
cord-015021-pol2qm74	6065	33	by	by	IN
cord-015021-pol2qm74	6065	34	bacteria	bacteria	NNS
cord-015021-pol2qm74	6065	35	.	.	.
cord-015021-pol2qm74	6066	1	The	the	DT
cord-015021-pol2qm74	6066	2	systemic	systemic	JJ
cord-015021-pol2qm74	6066	3	fever	fever	NN
cord-015021-pol2qm74	6066	4	observed	observe	VBN
cord-015021-pol2qm74	6066	5	in	in	IN
cord-015021-pol2qm74	6066	6	infection	infection	NN
cord-015021-pol2qm74	6066	7	is	be	VBZ
cord-015021-pol2qm74	6066	8	known	know	VBN
cord-015021-pol2qm74	6066	9	to	to	TO
cord-015021-pol2qm74	6066	10	develop	develop	VB
cord-015021-pol2qm74	6066	11	due	due	IN
cord-015021-pol2qm74	6066	12	to	to	IN
cord-015021-pol2qm74	6066	13	the	the	DT
cord-015021-pol2qm74	6066	14	action	action	NN
cord-015021-pol2qm74	6066	15	of	of	IN
cord-015021-pol2qm74	6066	16	certain	certain	JJ
cord-015021-pol2qm74	6066	17	cytoldnes	cytoldne	NNS
cord-015021-pol2qm74	6066	18	.	.	.
cord-015021-pol2qm74	6067	1	Other	other	JJ
cord-015021-pol2qm74	6067	2	systemic	systemic	JJ
cord-015021-pol2qm74	6067	3	manffistation	manffistation	NN
cord-015021-pol2qm74	6067	4	of	of	IN
cord-015021-pol2qm74	6067	5	inflammation	inflammation	NN
cord-015021-pol2qm74	6067	6	are	be	VBP
cord-015021-pol2qm74	6067	7	the	the	DT
cord-015021-pol2qm74	6067	8	production	production	NN
cord-015021-pol2qm74	6067	9	of	of	IN
cord-015021-pol2qm74	6067	10	acute	acute	JJ
cord-015021-pol2qm74	6067	11	phase	phase	NN
cord-015021-pol2qm74	6067	12	reactants	reactant	NNS
cord-015021-pol2qm74	6067	13	,	,	,
cord-015021-pol2qm74	6067	14	acute	acute	JJ
cord-015021-pol2qm74	6067	15	phase	phase	NN
cord-015021-pol2qm74	6067	16	proteins	protein	NNS
cord-015021-pol2qm74	6067	17	,	,	,
cord-015021-pol2qm74	6067	18	the	the	DT
cord-015021-pol2qm74	6067	19	activation	activation	NN
cord-015021-pol2qm74	6067	20	of	of	IN
cord-015021-pol2qm74	6067	21	the	the	DT
cord-015021-pol2qm74	6067	22	complement	complement	NN
cord-015021-pol2qm74	6067	23	system	system	NN
cord-015021-pol2qm74	6067	24	.	.	.
cord-015021-pol2qm74	6068	1	IVratertals	ivratertal	NNS
cord-015021-pol2qm74	6068	2	and	and	CC
cord-015021-pol2qm74	6068	3	methods	method	NNS
cord-015021-pol2qm74	6068	4	.	.	.
cord-015021-pol2qm74	6069	1	We	-PRON-	PRP
cord-015021-pol2qm74	6069	2	observed	observe	VBD
cord-015021-pol2qm74	6069	3	35	35	CD
cord-015021-pol2qm74	6069	4	children	child	NNS
cord-015021-pol2qm74	6069	5	with	with	IN
cord-015021-pol2qm74	6069	6	light	light	NN
cord-015021-pol2qm74	6069	7	and	and	CC
cord-015021-pol2qm74	6069	8	45	45	CD
cord-015021-pol2qm74	6069	9	children	child	NNS
cord-015021-pol2qm74	6069	10	with	with	IN
cord-015021-pol2qm74	6069	11	severe	severe	JJ
cord-015021-pol2qm74	6069	12	course(l-3	course(l-3	NNP
cord-015021-pol2qm74	6069	13	class	class	NN
cord-015021-pol2qm74	6069	14	of	of	IN
cord-015021-pol2qm74	6069	15	serionuess	serionuess	NNP
cord-015021-pol2qm74	6069	16	)	)	-RRB-
cord-015021-pol2qm74	6069	17	of	of	IN
cord-015021-pol2qm74	6069	18	the	the	DT
cord-015021-pol2qm74	6069	19	sepsis	sepsis	NN
cord-015021-pol2qm74	6069	20	.	.	.
cord-015021-pol2qm74	6070	1	The	the	DT
cord-015021-pol2qm74	6070	2	ftmetional	ftmetional	JJ
cord-015021-pol2qm74	6070	3	activity	activity	NN
cord-015021-pol2qm74	6070	4	of	of	IN
cord-015021-pol2qm74	6070	5	the	the	DT
cord-015021-pol2qm74	6070	6	complement	complement	NN
cord-015021-pol2qm74	6070	7	system	system	NN
cord-015021-pol2qm74	6070	8	(	(	-LRB-
cord-015021-pol2qm74	6070	9	CH50	CH50	NNP
cord-015021-pol2qm74	6070	10	,	,	,
cord-015021-pol2qm74	6070	11	level	level	NN
cord-015021-pol2qm74	6070	12	of	of	IN
cord-015021-pol2qm74	6070	13	C	C	NNP
cord-015021-pol2qm74	6070	14	1-C5	1-c5	CD
cord-015021-pol2qm74	6070	15	,	,	,
cord-015021-pol2qm74	6070	16	factors	factor	NNS
cord-015021-pol2qm74	6070	17	B	B	NNP
cord-015021-pol2qm74	6070	18	told	tell	VBD
cord-015021-pol2qm74	6070	19	D	D	NNP
cord-015021-pol2qm74	6070	20	,	,	,
cord-015021-pol2qm74	6070	21	C3a	C3a	NNP
cord-015021-pol2qm74	6070	22	)	)	-RRB-
cord-015021-pol2qm74	6070	23	,	,	,
cord-015021-pol2qm74	6070	24	level	level	NN
cord-015021-pol2qm74	6070	25	of	of	IN
cord-015021-pol2qm74	6070	26	C	c	NN
cord-015021-pol2qm74	6070	27	-	-	HYPH
cord-015021-pol2qm74	6070	28	reactive	reactive	JJ
cord-015021-pol2qm74	6070	29	protein	protein	NN
cord-015021-pol2qm74	6070	30	(	(	-LRB-
cord-015021-pol2qm74	6070	31	CRP	CRP	NNP
cord-015021-pol2qm74	6070	32	}	}	-RRB-
cord-015021-pol2qm74	6070	33	and	and	CC
cord-015021-pol2qm74	6070	34	tumor	tumor	NN
cord-015021-pol2qm74	6070	35	necrosis	necrosis	NN
cord-015021-pol2qm74	6070	36	factor	factor	NN
cord-015021-pol2qm74	6070	37	(	(	-LRB-
cord-015021-pol2qm74	6070	38	TNF	TNF	NNP
cord-015021-pol2qm74	6070	39	)	)	-RRB-
cord-015021-pol2qm74	6070	40	were	be	VBD
cord-015021-pol2qm74	6070	41	investigated	investigate	VBN
cord-015021-pol2qm74	6070	42	,	,	,
cord-015021-pol2qm74	6070	43	Results	result	NNS
cord-015021-pol2qm74	6070	44	.	.	.
cord-015021-pol2qm74	6071	1	The	the	DT
cord-015021-pol2qm74	6071	2	level	level	NN
cord-015021-pol2qm74	6071	3	of	of	IN
cord-015021-pol2qm74	6071	4	CRP	CRP	NNP
cord-015021-pol2qm74	6071	5	was	be	VBD
cord-015021-pol2qm74	6071	6	increased	increase	VBN
cord-015021-pol2qm74	6071	7	in	in	IN
cord-015021-pol2qm74	6071	8	the	the	DT
cord-015021-pol2qm74	6071	9	children	child	NNS
cord-015021-pol2qm74	6071	10	with	with	IN
cord-015021-pol2qm74	6071	11	more	more	RBR
cord-015021-pol2qm74	6071	12	severe	severe	JJ
cord-015021-pol2qm74	6071	13	class	class	NN
cord-015021-pol2qm74	6071	14	of	of	IN
cord-015021-pol2qm74	6071	15	the	the	DT
cord-015021-pol2qm74	6071	16	septic	septic	JJ
cord-015021-pol2qm74	6071	17	process	process	NN
cord-015021-pol2qm74	6071	18	in	in	IN
cord-015021-pol2qm74	6071	19	both	both	DT
cord-015021-pol2qm74	6071	20	group	group	NN
cord-015021-pol2qm74	6071	21	(	(	-LRB-
cord-015021-pol2qm74	6071	22	60%-1	60%-1	CD
cord-015021-pol2qm74	6071	23	st	st	NNP
cord-015021-pol2qm74	6071	24	and	and	CC
cord-015021-pol2qm74	6071	25	iOO%-2	iOO%-2	NNP
cord-015021-pol2qm74	6071	26	nd	nd	NNP
cord-015021-pol2qm74	6071	27	}	}	-RRB-
cord-015021-pol2qm74	6071	28	(	(	-LRB-
cord-015021-pol2qm74	6071	29	with	with	IN
cord-015021-pol2qm74	6071	30	light	light	JJ
cord-015021-pol2qm74	6071	31	and	and	CC
cord-015021-pol2qm74	6071	32	hard	hard	JJ
cord-015021-pol2qm74	6071	33	eours	eour	NNS
cord-015021-pol2qm74	6071	34	of	of	IN
cord-015021-pol2qm74	6071	35	disese	disese	NNP
cord-015021-pol2qm74	6071	36	)	)	-RRB-
cord-015021-pol2qm74	6071	37	of	of	IN
cord-015021-pol2qm74	6071	38	patients	patient	NNS
cord-015021-pol2qm74	6071	39	.	.	.
cord-015021-pol2qm74	6072	1	Parameters	parameter	NNS
cord-015021-pol2qm74	6072	2	of	of	IN
cord-015021-pol2qm74	6072	3	the	the	DT
cord-015021-pol2qm74	6072	4	complement	complement	NN
cord-015021-pol2qm74	6072	5	system	system	NN
cord-015021-pol2qm74	6072	6	-the	-the	WDT
cord-015021-pol2qm74	6072	7	activity	activity	NN
cord-015021-pol2qm74	6072	8	of	of	IN
cord-015021-pol2qm74	6072	9	Cl	Cl	NNP
cord-015021-pol2qm74	6072	10	,	,	,
cord-015021-pol2qm74	6072	11	C4	C4	NNP
cord-015021-pol2qm74	6072	12	,	,	,
cord-015021-pol2qm74	6072	13	C3	c3	NN
cord-015021-pol2qm74	6072	14	components	component	NNS
cord-015021-pol2qm74	6072	15	,	,	,
cord-015021-pol2qm74	6072	16	activity	activity	NN
cord-015021-pol2qm74	6072	17	of	of	IN
cord-015021-pol2qm74	6072	18	B	b	NN
cord-015021-pol2qm74	6072	19	and	and	CC
cord-015021-pol2qm74	6072	20	D	d	NN
cord-015021-pol2qm74	6072	21	factors	factor	NNS
cord-015021-pol2qm74	6072	22	-	-	,
cord-015021-pol2qm74	6072	23	were	be	VBD
cord-015021-pol2qm74	6072	24	increased	increase	VBN
cord-015021-pol2qm74	6072	25	in	in	IN
cord-015021-pol2qm74	6072	26	the	the	DT
cord-015021-pol2qm74	6072	27	seram	seram	NNP
cord-015021-pol2qm74	6072	28	of	of	IN
cord-015021-pol2qm74	6072	29	children	child	NNS
cord-015021-pol2qm74	6072	30	with	with	IN
cord-015021-pol2qm74	6072	31	light	light	JJ
cord-015021-pol2qm74	6072	32	course	course	NN
cord-015021-pol2qm74	6072	33	of	of	IN
cord-015021-pol2qm74	6072	34	sepsis	sepsis	NN
cord-015021-pol2qm74	6072	35	.	.	.
cord-015021-pol2qm74	6073	1	In	in	IN
cord-015021-pol2qm74	6073	2	children	child	NNS
cord-015021-pol2qm74	6073	3	with	with	IN
cord-015021-pol2qm74	6073	4	severe	severe	JJ
cord-015021-pol2qm74	6073	5	course	course	NN
cord-015021-pol2qm74	6073	6	of	of	IN
cord-015021-pol2qm74	6073	7	sepsis	sepsis	NN
cord-015021-pol2qm74	6073	8	these	these	DT
cord-015021-pol2qm74	6073	9	parameters	parameter	NNS
cord-015021-pol2qm74	6073	10	were	be	VBD
cord-015021-pol2qm74	6073	11	signffieantty	signffieantty	JJ
cord-015021-pol2qm74	6073	12	decreased	decrease	VBD
cord-015021-pol2qm74	6073	13	,	,	,
cord-015021-pol2qm74	6073	14	especially	especially	RB
cord-015021-pol2qm74	6073	15	in	in	IN
cord-015021-pol2qm74	6073	16	the	the	DT
cord-015021-pol2qm74	6073	17	group	group	NN
cord-015021-pol2qm74	6073	18	of	of	IN
cord-015021-pol2qm74	6073	19	chiidrellwith	chiidrellwith	NNP
cord-015021-pol2qm74	6073	20	higer	hig	JJR
cord-015021-pol2qm74	6073	21	level	level	NN
cord-015021-pol2qm74	6073	22	of	of	IN
cord-015021-pol2qm74	6073	23	CRP	crp	NN
cord-015021-pol2qm74	6073	24	.	.	.
cord-015021-pol2qm74	6074	1	We	-PRON-	PRP
cord-015021-pol2qm74	6074	2	found	find	VBD
cord-015021-pol2qm74	6074	3	the	the	DT
cord-015021-pol2qm74	6074	4	negative	negative	JJ
cord-015021-pol2qm74	6074	5	correlation	correlation	NN
cord-015021-pol2qm74	6074	6	of	of	IN
cord-015021-pol2qm74	6074	7	the	the	DT
cord-015021-pol2qm74	6074	8	TNP	TNP	NNP
cord-015021-pol2qm74	6074	9	-	-	HYPH
cord-015021-pol2qm74	6074	10	alfa	alfa	NNP
cord-015021-pol2qm74	6074	11	concentration	concentration	NN
cord-015021-pol2qm74	6074	12	with	with	IN
cord-015021-pol2qm74	6074	13	the	the	DT
cord-015021-pol2qm74	6074	14	functional	functional	JJ
cord-015021-pol2qm74	6074	15	activity	activity	NN
cord-015021-pol2qm74	6074	16	of	of	IN
cord-015021-pol2qm74	6074	17	classical	classical	JJ
cord-015021-pol2qm74	6074	18	pathway	pathway	NN
cord-015021-pol2qm74	6074	19	components	component	NNS
cord-015021-pol2qm74	6074	20	(	(	-LRB-
cord-015021-pol2qm74	6074	21	Cl~3	Cl~3	NNP
cord-015021-pol2qm74	6074	22	)	)	-RRB-
cord-015021-pol2qm74	6074	23	and	and	CC
cord-015021-pol2qm74	6074	24	the	the	DT
cord-015021-pol2qm74	6074	25	positive	positive	JJ
cord-015021-pol2qm74	6074	26	onewith	onewith	NN
cord-015021-pol2qm74	6074	27	the	the	DT
cord-015021-pol2qm74	6074	28	funfional	funfional	JJ
cord-015021-pol2qm74	6074	29	activity	activity	NN
cord-015021-pol2qm74	6074	30	of	of	IN
cord-015021-pol2qm74	6074	31	the	the	DT
cord-015021-pol2qm74	6074	32	alternative	alternative	JJ
cord-015021-pol2qm74	6074	33	pathway	pathway	NN
cord-015021-pol2qm74	6074	34	factors	factor	NNS
cord-015021-pol2qm74	6074	35	B	b	NN
cord-015021-pol2qm74	6074	36	-	-	:
cord-015021-pol2qm74	6074	37	and	and	CC
cord-015021-pol2qm74	6074	38	D	d	NN
cord-015021-pol2qm74	6074	39	of	of	IN
cord-015021-pol2qm74	6074	40	the	the	DT
cord-015021-pol2qm74	6074	41	complement	complement	NN
cord-015021-pol2qm74	6074	42	system	system	NN
cord-015021-pol2qm74	6074	43	.	.	.
cord-015021-pol2qm74	6075	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	6075	2	.	.	.
cord-015021-pol2qm74	6076	1	Thus	thus	RB
cord-015021-pol2qm74	6076	2	,	,	,
cord-015021-pol2qm74	6076	3	in	in	IN
cord-015021-pol2qm74	6076	4	children	child	NNS
cord-015021-pol2qm74	6076	5	with	with	IN
cord-015021-pol2qm74	6076	6	different	different	JJ
cord-015021-pol2qm74	6076	7	course	course	NN
cord-015021-pol2qm74	6076	8	of	of	IN
cord-015021-pol2qm74	6076	9	sepsis	sepsis	NN
cord-015021-pol2qm74	6076	10	certain	certain	JJ
cord-015021-pol2qm74	6076	11	changes	change	NNS
cord-015021-pol2qm74	6076	12	in	in	IN
cord-015021-pol2qm74	6076	13	levels	level	NNS
cord-015021-pol2qm74	6076	14	and	and	CC
cord-015021-pol2qm74	6076	15	functional	functional	JJ
cord-015021-pol2qm74	6076	16	activity	activity	NN
cord-015021-pol2qm74	6076	17	of	of	IN
cord-015021-pol2qm74	6076	18	an	an	DT
cord-015021-pol2qm74	6076	19	acute	acute	JJ
cord-015021-pol2qm74	6076	20	phase	phase	NN
cord-015021-pol2qm74	6076	21	o	o	NN
cord-015021-pol2qm74	6076	22	[	[	-LRB-
cord-015021-pol2qm74	6076	23	inflammation	inflammation	NN
cord-015021-pol2qm74	6076	24	proteins	protein	NNS
cord-015021-pol2qm74	6076	25	-CRP	-CRP	:
cord-015021-pol2qm74	6076	26	and	and	CC
cord-015021-pol2qm74	6076	27	the	the	DT
cord-015021-pol2qm74	6076	28	complement	complement	NN
cord-015021-pol2qm74	6076	29	system	system	NN
cord-015021-pol2qm74	6076	30	ones	one	NNS
cord-015021-pol2qm74	6076	31	-&Ire	-&Ire	.
cord-015021-pol2qm74	6077	1	characteristic	characteristic	JJ
cord-015021-pol2qm74	6077	2	.	.	.
cord-015021-pol2qm74	6078	1	The	the	DT
cord-015021-pol2qm74	6078	2	relationship	relationship	NN
cord-015021-pol2qm74	6078	3	between	between	IN
cord-015021-pol2qm74	6078	4	the	the	DT
cord-015021-pol2qm74	6078	5	TNF	TNF	NNP
cord-015021-pol2qm74	6078	6	-	-	HYPH
cord-015021-pol2qm74	6078	7	alfa	alfa	NNP
cord-015021-pol2qm74	6078	8	level	level	NN
cord-015021-pol2qm74	6078	9	and	and	CC
cord-015021-pol2qm74	6078	10	the	the	DT
cord-015021-pol2qm74	6078	11	activity	activity	NN
cord-015021-pol2qm74	6078	12	of	of	IN
cord-015021-pol2qm74	6078	13	classical	classical	JJ
cord-015021-pol2qm74	6078	14	and	and	CC
cord-015021-pol2qm74	6078	15	alternative	alternative	JJ
cord-015021-pol2qm74	6078	16	pathways	pathway	NNS
cord-015021-pol2qm74	6078	17	proteins	protein	NNS
cord-015021-pol2qm74	6078	18	indicates	indicate	VBZ
cord-015021-pol2qm74	6078	19	on	on	IN
cord-015021-pol2qm74	6078	20	its	-PRON-	PRP$
cord-015021-pol2qm74	6078	21	role	role	NN
cord-015021-pol2qm74	6078	22	in	in	IN
cord-015021-pol2qm74	6078	23	the	the	DT
cord-015021-pol2qm74	6078	24	complement	complement	NN
cord-015021-pol2qm74	6078	25	proteins	protein	NNS
cord-015021-pol2qm74	6078	26	genes	gene	NNS
cord-015021-pol2qm74	6078	27	expression	expression	NN
cord-015021-pol2qm74	6078	28	.	.	.
cord-015021-pol2qm74	6078	29	 	 	_SP
cord-015021-pol2qm74	6079	1	Schr6der	Schr6der	NNP
cord-015021-pol2qm74	6079	2	J	J	NNP
cord-015021-pol2qm74	6079	3	,	,	,
cord-015021-pol2qm74	6079	4	Braun	Braun	NNP
cord-015021-pol2qm74	6079	5	J	J	NNP
cord-015021-pol2qm74	6079	6	,	,	,
cord-015021-pol2qm74	6079	7	Rennekampff	Rennekampff	NNP
cord-015021-pol2qm74	6079	8	Ha	Ha	NNP
cord-015021-pol2qm74	6079	9	,	,	,
cord-015021-pol2qm74	6079	10	Schr6der	schr6der	NN
cord-015021-pol2qm74	6079	11	DW	DW	NNP
cord-015021-pol2qm74	6079	12	Various	various	JJ
cord-015021-pol2qm74	6079	13	alterations	alteration	NNS
cord-015021-pol2qm74	6079	14	of	of	IN
cord-015021-pol2qm74	6079	15	the	the	DT
cord-015021-pol2qm74	6079	16	immune	immune	JJ
cord-015021-pol2qm74	6079	17	response	response	NN
cord-015021-pol2qm74	6079	18	are	be	VBP
cord-015021-pol2qm74	6079	19	known	know	VBN
cord-015021-pol2qm74	6079	20	in	in	IN
cord-015021-pol2qm74	6079	21	trauma	trauma	NN
cord-015021-pol2qm74	6079	22	,	,	,
cord-015021-pol2qm74	6079	23	but	but	CC
cord-015021-pol2qm74	6079	24	the	the	DT
cord-015021-pol2qm74	6079	25	course	course	NN
cord-015021-pol2qm74	6079	26	will	will	MD
cord-015021-pol2qm74	6079	27	not	not	RB
cord-015021-pol2qm74	6079	28	be	be	VB
cord-015021-pol2qm74	6079	29	complicated	complicate	VBN
cord-015021-pol2qm74	6079	30	by	by	IN
cord-015021-pol2qm74	6079	31	multiple	multiple	JJ
cord-015021-pol2qm74	6079	32	organ	organ	NN
cord-015021-pol2qm74	6079	33	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6079	34	syndrome	syndrome	NN
cord-015021-pol2qm74	6079	35	(	(	-LRB-
cord-015021-pol2qm74	6079	36	MODS	MODS	NNP
cord-015021-pol2qm74	6079	37	)	)	-RRB-
cord-015021-pol2qm74	6079	38	in	in	IN
cord-015021-pol2qm74	6079	39	all	all	DT
cord-015021-pol2qm74	6079	40	patients	patient	NNS
cord-015021-pol2qm74	6079	41	.	.	.
cord-015021-pol2qm74	6080	1	Phenotyping	phenotyping	NN
cord-015021-pol2qm74	6080	2	of	of	IN
cord-015021-pol2qm74	6080	3	cells	cell	NNS
cord-015021-pol2qm74	6080	4	offers	offer	VBZ
cord-015021-pol2qm74	6080	5	a	a	DT
cord-015021-pol2qm74	6080	6	rapid	rapid	JJ
cord-015021-pol2qm74	6080	7	system	system	NN
cord-015021-pol2qm74	6080	8	of	of	IN
cord-015021-pol2qm74	6080	9	evaluation	evaluation	NN
cord-015021-pol2qm74	6080	10	certain	certain	JJ
cord-015021-pol2qm74	6080	11	aspects	aspect	NNS
cord-015021-pol2qm74	6080	12	of	of	IN
cord-015021-pol2qm74	6080	13	the	the	DT
cord-015021-pol2qm74	6080	14	immune	immune	JJ
cord-015021-pol2qm74	6080	15	response	response	NN
cord-015021-pol2qm74	6080	16	.	.	.
cord-015021-pol2qm74	6081	1	Different	different	JJ
cord-015021-pol2qm74	6081	2	subsets	subset	NNS
cord-015021-pol2qm74	6081	3	of	of	IN
cord-015021-pol2qm74	6081	4	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	6081	5	and	and	CC
cord-015021-pol2qm74	6081	6	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	6081	7	were	be	VBD
cord-015021-pol2qm74	6081	8	determined	determine	VBN
cord-015021-pol2qm74	6081	9	to	to	TO
cord-015021-pol2qm74	6081	10	evaluate	evaluate	VB
cord-015021-pol2qm74	6081	11	their	-PRON-	PRP$
cord-015021-pol2qm74	6081	12	prognostic	prognostic	JJ
cord-015021-pol2qm74	6081	13	role	role	NN
cord-015021-pol2qm74	6081	14	in	in	IN
cord-015021-pol2qm74	6081	15	developement	developement	NN
cord-015021-pol2qm74	6081	16	of	of	IN
cord-015021-pol2qm74	6081	17	MODS	MODS	NNP
cord-015021-pol2qm74	6081	18	.	.	.
cord-015021-pol2qm74	6082	1	In	in	IN
cord-015021-pol2qm74	6082	2	16	16	CD
cord-015021-pol2qm74	6082	3	trauma	trauma	NN
cord-015021-pol2qm74	6082	4	patients	patient	NNS
cord-015021-pol2qm74	6082	5	with	with	IN
cord-015021-pol2qm74	6082	6	an	an	DT
cord-015021-pol2qm74	6082	7	injury	injury	NN
cord-015021-pol2qm74	6082	8	severity	severity	NN
cord-015021-pol2qm74	6082	9	score	score	NN
cord-015021-pol2qm74	6082	10	(	(	-LRB-
cord-015021-pol2qm74	6082	11	ISS	ISS	NNP
cord-015021-pol2qm74	6082	12	)	)	-RRB-
cord-015021-pol2qm74	6082	13	>	>	NFP
cord-015021-pol2qm74	6082	14	20	20	CD
cord-015021-pol2qm74	6082	15	(	(	-LRB-
cord-015021-pol2qm74	6082	16	mean	mean	VB
cord-015021-pol2qm74	6082	17	ISS	ISS	NNP
cord-015021-pol2qm74	6082	18	=	=	SYM
cord-015021-pol2qm74	6082	19	32	32	CD
cord-015021-pol2qm74	6082	20	;	;	:
cord-015021-pol2qm74	6082	21	mean	mean	VB
cord-015021-pol2qm74	6082	22	age	age	NN
cord-015021-pol2qm74	6082	23	41	41	CD
cord-015021-pol2qm74	6082	24	years	year	NNS
cord-015021-pol2qm74	6082	25	)	)	-RRB-
cord-015021-pol2qm74	6082	26	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	6082	27	and	and	CC
cord-015021-pol2qm74	6082	28	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6082	29	phenotypes	phenotype	NNS
cord-015021-pol2qm74	6082	30	CD	cd	NN
cord-015021-pol2qm74	6082	31	3	3	CD
cord-015021-pol2qm74	6083	1	(	(	-LRB-
cord-015021-pol2qm74	6083	2	T	t	NN
cord-015021-pol2qm74	6083	3	-	-	HYPH
cord-015021-pol2qm74	6083	4	cells	cell	NNS
cord-015021-pol2qm74	6083	5	)	)	-RRB-
cord-015021-pol2qm74	6083	6	,	,	,
cord-015021-pol2qm74	6083	7	CD	CD	NNP
cord-015021-pol2qm74	6083	8	4	4	CD
cord-015021-pol2qm74	6084	1	(	(	-LRB-
cord-015021-pol2qm74	6084	2	T	t	NN
cord-015021-pol2qm74	6084	3	-	-	HYPH
cord-015021-pol2qm74	6084	4	helper	helper	NN
cord-015021-pol2qm74	6084	5	cells	cell	NNS
cord-015021-pol2qm74	6084	6	)	)	-RRB-
cord-015021-pol2qm74	6084	7	,	,	,
cord-015021-pol2qm74	6084	8	CD	CD	NNP
cord-015021-pol2qm74	6084	9	8	8	CD
cord-015021-pol2qm74	6084	10	(	(	-LRB-
cord-015021-pol2qm74	6084	11	T	t	NN
cord-015021-pol2qm74	6084	12	-	-	HYPH
cord-015021-pol2qm74	6084	13	suppressor	suppressor	NN
cord-015021-pol2qm74	6084	14	cells	cell	NNS
cord-015021-pol2qm74	6084	15	)	)	-RRB-
cord-015021-pol2qm74	6085	1	,	,	,
cord-015021-pol2qm74	6085	2	ratio	ratio	NN
cord-015021-pol2qm74	6085	3	CD	CD	NNP
cord-015021-pol2qm74	6085	4	4	4	CD
cord-015021-pol2qm74	6085	5	/	/	SYM
cord-015021-pol2qm74	6085	6	CD	CD	NNP
cord-015021-pol2qm74	6085	7	8	8	CD
cord-015021-pol2qm74	6085	8	,	,	,
cord-015021-pol2qm74	6085	9	CD	cd	NN
cord-015021-pol2qm74	6085	10	11b	11b	NNS
cord-015021-pol2qm74	6086	1	(	(	-LRB-
cord-015021-pol2qm74	6086	2	receptor	receptor	NN
cord-015021-pol2qm74	6086	3	for	for	IN
cord-015021-pol2qm74	6086	4	CR	CR	NNP
cord-015021-pol2qm74	6086	5	3	3	CD
cord-015021-pol2qm74	6086	6	)	)	-RRB-
cord-015021-pol2qm74	6086	7	and	and	CC
cord-015021-pol2qm74	6086	8	CD	CD	NNP
cord-015021-pol2qm74	6086	9	16	16	CD
cord-015021-pol2qm74	6087	1	(	(	-LRB-
cord-015021-pol2qm74	6087	2	FcRIII	FcRIII	NNP
cord-015021-pol2qm74	6087	3	)	)	-RRB-
cord-015021-pol2qm74	6087	4	were	be	VBD
cord-015021-pol2qm74	6087	5	measured	measure	VBN
cord-015021-pol2qm74	6087	6	on	on	IN
cord-015021-pol2qm74	6087	7	day	day	NN
cord-015021-pol2qm74	6087	8	1,2,3,5,7	1,2,3,5,7	CD
cord-015021-pol2qm74	6087	9	and	and	CC
cord-015021-pol2qm74	6087	10	10	10	CD
cord-015021-pol2qm74	6087	11	post	post	NN
cord-015021-pol2qm74	6087	12	trauma	trauma	NN
cord-015021-pol2qm74	6087	13	.	.	.
cord-015021-pol2qm74	6088	1	The	the	DT
cord-015021-pol2qm74	6088	2	expression	expression	NN
cord-015021-pol2qm74	6088	3	of	of	IN
cord-015021-pol2qm74	6088	4	class	class	NN
cord-015021-pol2qm74	6088	5	II	II	NNP
cord-015021-pol2qm74	6088	6	histocompatibility	histocompatibility	NN
cord-015021-pol2qm74	6088	7	antigen	antigen	NN
cord-015021-pol2qm74	6088	8	(	(	-LRB-
cord-015021-pol2qm74	6088	9	HLADR	HLADR	NNP
cord-015021-pol2qm74	6088	10	)	)	-RRB-
cord-015021-pol2qm74	6088	11	on	on	IN
cord-015021-pol2qm74	6088	12	monocytes	monocyte	NNS
cord-015021-pol2qm74	6088	13	(	(	-LRB-
cord-015021-pol2qm74	6088	14	HLADR+	hladr+	DT
cord-015021-pol2qm74	6088	15	CD	CD	NNP
cord-015021-pol2qm74	6088	16	14	14	CD
cord-015021-pol2qm74	6088	17	)	)	-RRB-
cord-015021-pol2qm74	6088	18	and	and	CC
cord-015021-pol2qm74	6088	19	IL	IL	NNP
cord-015021-pol2qm74	6088	20	2-receptors	2-receptors	CD
cord-015021-pol2qm74	6088	21	on	on	IN
cord-015021-pol2qm74	6088	22	T	t	NN
cord-015021-pol2qm74	6088	23	-	-	HYPH
cord-015021-pol2qm74	6088	24	helper	helper	NN
cord-015021-pol2qm74	6088	25	cells	cell	NNS
cord-015021-pol2qm74	6088	26	(	(	-LRB-
cord-015021-pol2qm74	6088	27	CD	CD	NNP
cord-015021-pol2qm74	6088	28	25	25	CD
cord-015021-pol2qm74	6089	1	/CD	/cd	CD
cord-015021-pol2qm74	6089	2	41	41	CD
cord-015021-pol2qm74	6089	3	were	be	VBD
cord-015021-pol2qm74	6089	4	determined	determine	VBN
cord-015021-pol2qm74	6089	5	as	as	RB
cord-015021-pol2qm74	6089	6	well	well	RB
cord-015021-pol2qm74	6089	7	.	.	.
cord-015021-pol2qm74	6090	1	The	the	DT
cord-015021-pol2qm74	6090	2	percentage	percentage	NN
cord-015021-pol2qm74	6090	3	of	of	IN
cord-015021-pol2qm74	6090	4	cells	cell	NNS
cord-015021-pol2qm74	6090	5	was	be	VBD
cord-015021-pol2qm74	6090	6	monitored	monitor	VBN
cord-015021-pol2qm74	6090	7	by	by	IN
cord-015021-pol2qm74	6090	8	immunofluorescence	immunofluorescence	NN
cord-015021-pol2qm74	6090	9	using	use	VBG
cord-015021-pol2qm74	6090	10	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	6090	11	antibodies	antibody	NNS
cord-015021-pol2qm74	6090	12	and	and	CC
cord-015021-pol2qm74	6090	13	three	three	CD
cord-015021-pol2qm74	6090	14	color	color	NN
cord-015021-pol2qm74	6090	15	cytometry	cytometry	NN
cord-015021-pol2qm74	6090	16	.	.	.
cord-015021-pol2qm74	6091	1	The	the	DT
cord-015021-pol2qm74	6091	2	percentage	percentage	NN
cord-015021-pol2qm74	6091	3	of	of	IN
cord-015021-pol2qm74	6091	4	HLADR+	HLADR+	NNP
cord-015021-pol2qm74	6091	5	CD	CD	NNP
cord-015021-pol2qm74	6091	6	14	14	CD
cord-015021-pol2qm74	6091	7	were	be	VBD
cord-015021-pol2qm74	6091	8	significantly	significantly	RB
cord-015021-pol2qm74	6091	9	lower	low	JJR
cord-015021-pol2qm74	6091	10	an	an	DT
cord-015021-pol2qm74	6091	11	day	day	NN
cord-015021-pol2qm74	6091	12	2,5,7	2,5,7	CD
cord-015021-pol2qm74	6091	13	and	and	CC
cord-015021-pol2qm74	6091	14	10	10	CD
cord-015021-pol2qm74	6091	15	in	in	IN
cord-015021-pol2qm74	6091	16	patients	patient	NNS
cord-015021-pol2qm74	6091	17	who	who	WP
cord-015021-pol2qm74	6091	18	developed	develop	VBD
cord-015021-pol2qm74	6091	19	MODS	mod	NNS
cord-015021-pol2qm74	6091	20	(	(	-LRB-
cord-015021-pol2qm74	6091	21	p<0,05	p<0,05	NNP
cord-015021-pol2qm74	6091	22	)	)	-RRB-
cord-015021-pol2qm74	6091	23	compared	compare	VBN
cord-015021-pol2qm74	6091	24	to	to	IN
cord-015021-pol2qm74	6091	25	patients	patient	NNS
cord-015021-pol2qm74	6091	26	without	without	IN
cord-015021-pol2qm74	6091	27	MODS	mods	NN
cord-015021-pol2qm74	6091	28	and	and	CC
cord-015021-pol2qm74	6091	29	a	a	DT
cord-015021-pol2qm74	6091	30	healthy	healthy	JJ
cord-015021-pol2qm74	6091	31	control	control	NN
cord-015021-pol2qm74	6092	1	(	(	-LRB-
cord-015021-pol2qm74	6092	2	p	p	NN
cord-015021-pol2qm74	6092	3	<	<	XX
cord-015021-pol2qm74	6092	4	O	o	UH
cord-015021-pol2qm74	6092	5	,	,	,
cord-015021-pol2qm74	6092	6	O01	O01	NNP
cord-015021-pol2qm74	6092	7	)	)	-RRB-
cord-015021-pol2qm74	6092	8	.	.	.
cord-015021-pol2qm74	6093	1	The	the	DT
cord-015021-pol2qm74	6093	2	expression	expression	NN
cord-015021-pol2qm74	6093	3	of	of	IN
cord-015021-pol2qm74	6093	4	IL	IL	NNP
cord-015021-pol2qm74	6093	5	2receptors	2receptors	CD
cord-015021-pol2qm74	6093	6	on	on	IN
cord-015021-pol2qm74	6093	7	CD	CD	NNP
cord-015021-pol2qm74	6093	8	4	4	CD
cord-015021-pol2qm74	6093	9	was	be	VBD
cord-015021-pol2qm74	6093	10	significantly	significantly	RB
cord-015021-pol2qm74	6093	11	different	different	JJ
cord-015021-pol2qm74	6093	12	only	only	RB
cord-015021-pol2qm74	6093	13	on	on	IN
cord-015021-pol2qm74	6093	14	day	day	NN
cord-015021-pol2qm74	6093	15	2	2	CD
cord-015021-pol2qm74	6093	16	.	.	.
cord-015021-pol2qm74	6094	1	No	no	DT
cord-015021-pol2qm74	6094	2	differences	difference	NNS
cord-015021-pol2qm74	6094	3	could	could	MD
cord-015021-pol2qm74	6094	4	be	be	VB
cord-015021-pol2qm74	6094	5	measured	measure	VBN
cord-015021-pol2qm74	6094	6	in	in	IN
cord-015021-pol2qm74	6094	7	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	6094	8	phenotypes	phenotype	NNS
cord-015021-pol2qm74	6094	9	CD	CD	NNP
cord-015021-pol2qm74	6094	10	3	3	CD
cord-015021-pol2qm74	6094	11	,	,	,
cord-015021-pol2qm74	6094	12	4	4	CD
cord-015021-pol2qm74	6094	13	,	,	,
cord-015021-pol2qm74	6094	14	8	8	CD
cord-015021-pol2qm74	6094	15	and	and	CC
cord-015021-pol2qm74	6094	16	CD	CD	NNP
cord-015021-pol2qm74	6094	17	4	4	CD
cord-015021-pol2qm74	6094	18	/	/	SYM
cord-015021-pol2qm74	6094	19	CD	CD	NNP
cord-015021-pol2qm74	6094	20	8-ratio	8-ratio	CD
cord-015021-pol2qm74	6095	1	as	as	RB
cord-015021-pol2qm74	6095	2	well	well	RB
cord-015021-pol2qm74	6095	3	as	as	IN
cord-015021-pol2qm74	6095	4	in	in	IN
cord-015021-pol2qm74	6095	5	expression	expression	NN
cord-015021-pol2qm74	6095	6	of	of	IN
cord-015021-pol2qm74	6095	7	CD	CD	NNP
cord-015021-pol2qm74	6095	8	11b	11b	NNS
cord-015021-pol2qm74	6095	9	and	and	CC
cord-015021-pol2qm74	6095	10	CD	CD	NNP
cord-015021-pol2qm74	6095	11	16	16	CD
cord-015021-pol2qm74	6095	12	on	on	IN
cord-015021-pol2qm74	6095	13	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	6095	14	.	.	.
cord-015021-pol2qm74	6096	1	Class	Class	NNP
cord-015021-pol2qm74	6096	2	II	II	NNP
cord-015021-pol2qm74	6096	3	histocompatibility	histocompatibility	NN
cord-015021-pol2qm74	6096	4	antigen	antigen	NN
cord-015021-pol2qm74	6096	5	(	(	-LRB-
cord-015021-pol2qm74	6096	6	HLADR	HLADR	NNP
cord-015021-pol2qm74	6096	7	)	)	-RRB-
cord-015021-pol2qm74	6096	8	on	on	IN
cord-015021-pol2qm74	6096	9	monocytes	monocyte	NNS
cord-015021-pol2qm74	6096	10	offers	offer	VBZ
cord-015021-pol2qm74	6096	11	the	the	DT
cord-015021-pol2qm74	6096	12	best	good	JJS
cord-015021-pol2qm74	6096	13	ability	ability	NN
cord-015021-pol2qm74	6096	14	to	to	TO
cord-015021-pol2qm74	6096	15	reflect	reflect	VB
cord-015021-pol2qm74	6096	16	cellular	cellular	JJ
cord-015021-pol2qm74	6096	17	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	6096	18	in	in	IN
cord-015021-pol2qm74	6096	19	trauma	trauma	NN
cord-015021-pol2qm74	6096	20	.	.	.
cord-015021-pol2qm74	6097	1	This	this	DT
cord-015021-pol2qm74	6097	2	parameter	parameter	NN
cord-015021-pol2qm74	6097	3	allows	allow	VBZ
cord-015021-pol2qm74	6097	4	the	the	DT
cord-015021-pol2qm74	6097	5	best	good	JJS
cord-015021-pol2qm74	6097	6	differentiation	differentiation	NN
cord-015021-pol2qm74	6097	7	of	of	IN
cord-015021-pol2qm74	6097	8	patients	patient	NNS
cord-015021-pol2qm74	6097	9	with	with	IN
cord-015021-pol2qm74	6097	10	and	and	CC
cord-015021-pol2qm74	6097	11	without	without	IN
cord-015021-pol2qm74	6097	12	MODS	mod	NNS
cord-015021-pol2qm74	6097	13	.	.	.
cord-015021-pol2qm74	6098	1	We	-PRON-	PRP
cord-015021-pol2qm74	6098	2	retrospectively	retrospectively	RB
cord-015021-pol2qm74	6098	3	studied	study	VBD
cord-015021-pol2qm74	6098	4	the	the	DT
cord-015021-pol2qm74	6098	5	relative	relative	JJ
cord-015021-pol2qm74	6098	6	importance	importance	NN
cord-015021-pol2qm74	6098	7	of	of	IN
cord-015021-pol2qm74	6098	8	age	age	NN
cord-015021-pol2qm74	6098	9	,	,	,
cord-015021-pol2qm74	6098	10	prior	prior	JJ
cord-015021-pol2qm74	6098	11	chronic	chronic	JJ
cord-015021-pol2qm74	6098	12	disease	disease	NN
cord-015021-pol2qm74	6098	13	,	,	,
cord-015021-pol2qm74	6098	14	sepsis	sepsis	NN
cord-015021-pol2qm74	6098	15	and	and	CC
cord-015021-pol2qm74	6098	16	organ	organ	NN
cord-015021-pol2qm74	6098	17	system	system	NN
cord-015021-pol2qm74	6098	18	failure	failure	NN
cord-015021-pol2qm74	6098	19	(	(	-LRB-
cord-015021-pol2qm74	6098	20	OSF	OSF	NNP
cord-015021-pol2qm74	6098	21	)	)	-RRB-
cord-015021-pol2qm74	6098	22	to	to	TO
cord-015021-pol2qm74	6098	23	determine	determine	VB
cord-015021-pol2qm74	6098	24	outcome	outcome	NN
cord-015021-pol2qm74	6098	25	in	in	IN
cord-015021-pol2qm74	6098	26	critically	critically	RB
cord-015021-pol2qm74	6098	27	ill	ill	JJ
cord-015021-pol2qm74	6098	28	patients	patient	NNS
cord-015021-pol2qm74	6098	29	with	with	IN
cord-015021-pol2qm74	6098	30	acute	acute	JJ
cord-015021-pol2qm74	6098	31	renal	renal	JJ
cord-015021-pol2qm74	6098	32	failure	failure	NN
cord-015021-pol2qm74	6098	33	(	(	-LRB-
cord-015021-pol2qm74	6098	34	ARF	ARF	NNP
cord-015021-pol2qm74	6098	35	)	)	-RRB-
cord-015021-pol2qm74	6098	36	.	.	.
cord-015021-pol2qm74	6099	1	ARF	ARF	NNP
cord-015021-pol2qm74	6099	2	was	be	VBD
cord-015021-pol2qm74	6099	3	defined	define	VBN
cord-015021-pol2qm74	6099	4	as	as	IN
cord-015021-pol2qm74	6099	5	serum	serum	NN
cord-015021-pol2qm74	6099	6	creatinine	creatinine	NN
cord-015021-pol2qm74	6099	7	>	>	XX
cord-015021-pol2qm74	6099	8	280	280	CD
cord-015021-pol2qm74	6099	9	/	/	SYM
cord-015021-pol2qm74	6099	10	zmol/	zmol/	XX
cord-015021-pol2qm74	6100	1	I	-PRON-	PRP
cord-015021-pol2qm74	6100	2	,	,	,
cord-015021-pol2qm74	6100	3	a	a	DT
cord-015021-pol2qm74	6100	4	twofold	twofold	JJ
cord-015021-pol2qm74	6100	5	creatinine	creatinine	NN
cord-015021-pol2qm74	6100	6	rise	rise	NN
cord-015021-pol2qm74	6100	7	in	in	IN
cord-015021-pol2qm74	6100	8	prior	prior	JJ
cord-015021-pol2qm74	6100	9	renal	renal	JJ
cord-015021-pol2qm74	6100	10	insufficiency	insufficiency	NN
cord-015021-pol2qm74	6100	11	or	or	CC
cord-015021-pol2qm74	6100	12	the	the	DT
cord-015021-pol2qm74	6100	13	need	need	NN
cord-015021-pol2qm74	6100	14	of	of	IN
cord-015021-pol2qm74	6100	15	acute	acute	JJ
cord-015021-pol2qm74	6100	16	renal	renal	JJ
cord-015021-pol2qm74	6100	17	replacement	replacement	NN
cord-015021-pol2qm74	6100	18	therapy	therapy	NN
cord-015021-pol2qm74	6100	19	.	.	.
cord-015021-pol2qm74	6101	1	Definitions	definition	NNS
cord-015021-pol2qm74	6101	2	for	for	IN
cord-015021-pol2qm74	6101	3	prior	prior	JJ
cord-015021-pol2qm74	6101	4	chronic	chronic	JJ
cord-015021-pol2qm74	6101	5	disease	disease	NN
cord-015021-pol2qm74	6101	6	and	and	CC
cord-015021-pol2qm74	6101	7	other	other	JJ
cord-015021-pol2qm74	6101	8	OSFs	osf	NNS
cord-015021-pol2qm74	6101	9	-i.e	-i.e	ADD
cord-015021-pol2qm74	6101	10	.	.	.
cord-015021-pol2qm74	6102	1	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	6102	2	(	(	-LRB-
cord-015021-pol2qm74	6102	3	CF	CF	NNP
cord-015021-pol2qm74	6102	4	)	)	-RRB-
cord-015021-pol2qm74	6102	5	,	,	,
cord-015021-pol2qm74	6102	6	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	6102	7	(	(	-LRB-
cord-015021-pol2qm74	6102	8	PF	PF	NNP
cord-015021-pol2qm74	6102	9	)	)	-RRB-
cord-015021-pol2qm74	6102	10	,	,	,
cord-015021-pol2qm74	6102	11	neurological	neurological	JJ
cord-015021-pol2qm74	6102	12	(	(	-LRB-
cord-015021-pol2qm74	6102	13	NF	NF	NNP
cord-015021-pol2qm74	6102	14	)	)	-RRB-
cord-015021-pol2qm74	6102	15	,	,	,
cord-015021-pol2qm74	6102	16	haematological	haematological	FW
cord-015021-pol2qm74	6102	17	(	(	-LRB-
cord-015021-pol2qm74	6102	18	HF	HF	NNP
cord-015021-pol2qm74	6102	19	)	)	-RRB-
cord-015021-pol2qm74	6102	20	,	,	,
cord-015021-pol2qm74	6102	21	hepatic	hepatic	JJ
cord-015021-pol2qm74	6102	22	(	(	-LRB-
cord-015021-pol2qm74	6102	23	LF	LF	NNP
cord-015021-pol2qm74	6102	24	)	)	-RRB-
cord-015021-pol2qm74	6102	25	,	,	,
cord-015021-pol2qm74	6102	26	and	and	CC
cord-015021-pol2qm74	6102	27	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	6102	28	failure	failure	NN
cord-015021-pol2qm74	6102	29	(	(	-LRB-
cord-015021-pol2qm74	6102	30	GF)-were	gf)-were	CD
cord-015021-pol2qm74	6102	31	derived	derive	VBN
cord-015021-pol2qm74	6102	32	from	from	IN
cord-015021-pol2qm74	6102	33	the	the	DT
cord-015021-pol2qm74	6102	34	literature	literature	NN
cord-015021-pol2qm74	6102	35	and	and	CC
cord-015021-pol2qm74	6102	36	described	describe	VBD
cord-015021-pol2qm74	6102	37	previously	previously	RB
cord-015021-pol2qm74	6102	38	.	.	.
cord-015021-pol2qm74	6103	1	Of	of	IN
cord-015021-pol2qm74	6103	2	the	the	DT
cord-015021-pol2qm74	6103	3	1025	1025	CD
cord-015021-pol2qm74	6103	4	consecutively	consecutively	RB
cord-015021-pol2qm74	6103	5	admitted	admit	VBD
cord-015021-pol2qm74	6103	6	patients	patient	NNS
cord-015021-pol2qm74	6103	7	to	to	IN
cord-015021-pol2qm74	6103	8	a	a	DT
cord-015021-pol2qm74	6103	9	surgical	surgical	JJ
cord-015021-pol2qm74	6103	10	and	and	CC
cord-015021-pol2qm74	6103	11	a	a	DT
cord-015021-pol2qm74	6103	12	medical	medical	JJ
cord-015021-pol2qm74	6103	13	intensive	intensive	JJ
cord-015021-pol2qm74	6103	14	care	care	NN
cord-015021-pol2qm74	6103	15	unit	unit	NN
cord-015021-pol2qm74	6103	16	during	during	IN
cord-015021-pol2qm74	6103	17	1	1	CD
cord-015021-pol2qm74	6103	18	-ye0r	-ye0r	NN
cord-015021-pol2qm74	6103	19	period	period	NN
cord-015021-pol2qm74	6103	20	,	,	,
cord-015021-pol2qm74	6103	21	136	136	CD
cord-015021-pol2qm74	6103	22	(	(	-LRB-
cord-015021-pol2qm74	6103	23	13	13	CD
cord-015021-pol2qm74	6103	24	%	%	NN
cord-015021-pol2qm74	6103	25	)	)	-RRB-
cord-015021-pol2qm74	6103	26	had	have	VBD
cord-015021-pol2qm74	6103	27	ARF	arf	NN
cord-015021-pol2qm74	6103	28	.	.	.
cord-015021-pol2qm74	6104	1	ARF	ARF	NNP
cord-015021-pol2qm74	6104	2	mortality	mortality	NN
cord-015021-pol2qm74	6104	3	was	be	VBD
cord-015021-pol2qm74	6104	4	52	52	CD
cord-015021-pol2qm74	6104	5	%	%	NN
cord-015021-pol2qm74	6104	6	.	.	.
cord-015021-pol2qm74	6105	1	Ninety	ninety	CD
cord-015021-pol2qm74	6105	2	-	-	HYPH
cord-015021-pol2qm74	6105	3	eight	eight	CD
cord-015021-pol2qm74	6105	4	percent	percent	NN
cord-015021-pol2qm74	6105	5	had	have	VBD
cord-015021-pol2qm74	6105	6	other	other	JJ
cord-015021-pol2qm74	6105	7	OSF	OSF	NNP
cord-015021-pol2qm74	6105	8	.	.	.
cord-015021-pol2qm74	6106	1	Overall	overall	RB
cord-015021-pol2qm74	6106	2	,	,	,
cord-015021-pol2qm74	6106	3	CF	CF	NNP
cord-015021-pol2qm74	6106	4	,	,	,
cord-015021-pol2qm74	6106	5	PF	PF	NNP
cord-015021-pol2qm74	6106	6	,	,	,
cord-015021-pol2qm74	6106	7	GF	GF	NNP
cord-015021-pol2qm74	6106	8	,	,	,
cord-015021-pol2qm74	6106	9	and	and	CC
cord-015021-pol2qm74	6106	10	NF	NF	NNP
cord-015021-pol2qm74	6106	11	was	be	VBD
cord-015021-pol2qm74	6106	12	significantly	significantly	RB
cord-015021-pol2qm74	6106	13	more	more	RBR
cord-015021-pol2qm74	6106	14	common	common	JJ
cord-015021-pol2qm74	6106	15	in	in	IN
cord-015021-pol2qm74	6106	16	nonsurvivors	nonsurvivor	NNS
cord-015021-pol2qm74	6106	17	than	than	IN
cord-015021-pol2qm74	6106	18	in	in	IN
cord-015021-pol2qm74	6106	19	survivors	survivor	NNS
cord-015021-pol2qm74	6106	20	(	(	-LRB-
cord-015021-pol2qm74	6106	21	all	all	DT
cord-015021-pol2qm74	6106	22	,	,	,
cord-015021-pol2qm74	6106	23	p	p	XX
cord-015021-pol2qm74	6106	24	<	<	XX
cord-015021-pol2qm74	6106	25	O,02	O,02	NNP
cord-015021-pol2qm74	6106	26	)	)	-RRB-
cord-015021-pol2qm74	6106	27	.	.	.
cord-015021-pol2qm74	6107	1	Although	although	IN
cord-015021-pol2qm74	6107	2	both	both	CC
cord-015021-pol2qm74	6107	3	the	the	DT
cord-015021-pol2qm74	6107	4	number	number	NN
cord-015021-pol2qm74	6107	5	of	of	IN
cord-015021-pol2qm74	6107	6	OSF	OSF	NNP
cord-015021-pol2qm74	6107	7	before	before	RB
cord-015021-pol2qm74	6107	8	and	and	CC
cord-015021-pol2qm74	6107	9	after	after	IN
cord-015021-pol2qm74	6107	10	ARF	ARF	NNP
cord-015021-pol2qm74	6107	11	was	be	VBD
cord-015021-pol2qm74	6107	12	higher	high	JJR
cord-015021-pol2qm74	6107	13	in	in	IN
cord-015021-pol2qm74	6107	14	nonsurvivors	nonsurvivor	NNS
cord-015021-pol2qm74	6107	15	than	than	IN
cord-015021-pol2qm74	6107	16	in	in	IN
cord-015021-pol2qm74	6107	17	survivors	survivor	NNS
cord-015021-pol2qm74	6107	18	(	(	-LRB-
cord-015021-pol2qm74	6107	19	p<0.02	p<0.02	NNP
cord-015021-pol2qm74	6107	20	)	)	-RRB-
cord-015021-pol2qm74	6107	21	,	,	,
cord-015021-pol2qm74	6107	22	the	the	DT
cord-015021-pol2qm74	6107	23	number	number	NN
cord-015021-pol2qm74	6107	24	of	of	IN
cord-015021-pol2qm74	6107	25	OSF	OSF	NNP
cord-015021-pol2qm74	6107	26	before	before	RB
cord-015021-pol2qm74	6107	27	was	be	VBD
cord-015021-pol2qm74	6107	28	higher	high	JJR
cord-015021-pol2qm74	6107	29	compared	compare	VBN
cord-015021-pol2qm74	6107	30	to	to	IN
cord-015021-pol2qm74	6107	31	after	after	IN
cord-015021-pol2qm74	6107	32	ARF	ARF	NNP
cord-015021-pol2qm74	6107	33	in	in	IN
cord-015021-pol2qm74	6107	34	both	both	DT
cord-015021-pol2qm74	6107	35	groups	group	NNS
cord-015021-pol2qm74	6107	36	of	of	IN
cord-015021-pol2qm74	6107	37	patients	patient	NNS
cord-015021-pol2qm74	6107	38	(	(	-LRB-
cord-015021-pol2qm74	6107	39	p<0.001	p<0.001	CD
cord-015021-pol2qm74	6107	40	)	)	-RRB-
cord-015021-pol2qm74	6107	41	.	.	.
cord-015021-pol2qm74	6108	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	6108	2	,	,	,
cord-015021-pol2qm74	6108	3	age	age	NN
cord-015021-pol2qm74	6108	4	,	,	,
cord-015021-pol2qm74	6108	5	CF	CF	NNP
cord-015021-pol2qm74	6108	6	and	and	CC
cord-015021-pol2qm74	6108	7	PF	PF	NNP
cord-015021-pol2qm74	6108	8	before	before	IN
cord-015021-pol2qm74	6108	9	the	the	DT
cord-015021-pol2qm74	6108	10	ontset	ontset	NN
cord-015021-pol2qm74	6108	11	of	of	IN
cord-015021-pol2qm74	6108	12	ARF	ARF	NNP
cord-015021-pol2qm74	6108	13	,	,	,
cord-015021-pol2qm74	6108	14	NF	NF	NNP
cord-015021-pol2qm74	6108	15	thereafter	thereafter	RB
cord-015021-pol2qm74	6108	16	,	,	,
cord-015021-pol2qm74	6108	17	and	and	CC
cord-015021-pol2qm74	6108	18	renal	renal	JJ
cord-015021-pol2qm74	6108	19	replacement	replacement	NN
cord-015021-pol2qm74	6108	20	therapy	therapy	NN
cord-015021-pol2qm74	6108	21	were	be	VBD
cord-015021-pol2qm74	6108	22	related	relate	VBN
cord-015021-pol2qm74	6108	23	to	to	IN
cord-015021-pol2qm74	6108	24	mortality	mortality	NN
cord-015021-pol2qm74	6108	25	(	(	-LRB-
cord-015021-pol2qm74	6108	26	all	all	DT
cord-015021-pol2qm74	6108	27	,	,	,
cord-015021-pol2qm74	6108	28	p<0.03	p<0.03	NN
cord-015021-pol2qm74	6108	29	)	)	-RRB-
cord-015021-pol2qm74	6108	30	.	.	.
cord-015021-pol2qm74	6109	1	However	however	RB
cord-015021-pol2qm74	6109	2	,	,	,
cord-015021-pol2qm74	6109	3	prior	prior	JJ
cord-015021-pol2qm74	6109	4	chronic	chronic	JJ
cord-015021-pol2qm74	6109	5	disease	disease	NN
cord-015021-pol2qm74	6109	6	was	be	VBD
cord-015021-pol2qm74	6109	7	not	not	RB
cord-015021-pol2qm74	6109	8	related	relate	VBN
cord-015021-pol2qm74	6109	9	to	to	IN
cord-015021-pol2qm74	6109	10	mortality	mortality	NN
cord-015021-pol2qm74	6109	11	and	and	CC
cord-015021-pol2qm74	6109	12	chronic	chronic	JJ
cord-015021-pol2qm74	6109	13	renal	renal	JJ
cord-015021-pol2qm74	6109	14	insufficiency	insufficiency	NN
cord-015021-pol2qm74	6109	15	was	be	VBD
cord-015021-pol2qm74	6109	16	inversely	inversely	RB
cord-015021-pol2qm74	6109	17	related	relate	VBN
cord-015021-pol2qm74	6109	18	to	to	IN
cord-015021-pol2qm74	6109	19	outcome	outcome	NN
cord-015021-pol2qm74	6109	20	(	(	-LRB-
cord-015021-pol2qm74	6109	21	p<0.002	p<0.002	CD
cord-015021-pol2qm74	6109	22	)	)	-RRB-
cord-015021-pol2qm74	6109	23	.	.	.
cord-015021-pol2qm74	6110	1	After	after	IN
cord-015021-pol2qm74	6110	2	multiple	multiple	JJ
cord-015021-pol2qm74	6110	3	logistic	logistic	JJ
cord-015021-pol2qm74	6110	4	regression	regression	NN
cord-015021-pol2qm74	6110	5	,	,	,
cord-015021-pol2qm74	6110	6	advancing	advance	VBG
cord-015021-pol2qm74	6110	7	age	age	NN
cord-015021-pol2qm74	6110	8	,	,	,
cord-015021-pol2qm74	6110	9	cardiopulrnonary	cardiopulrnonary	JJ
cord-015021-pol2qm74	6110	10	failure	failure	NN
cord-015021-pol2qm74	6110	11	and	and	CC
cord-015021-pol2qm74	6110	12	sepsis	sepsis	NN
cord-015021-pol2qm74	6110	13	before	before	IN
cord-015021-pol2qm74	6110	14	ARF	ARF	NNP
cord-015021-pol2qm74	6110	15	,	,	,
cord-015021-pol2qm74	6110	16	and	and	CC
cord-015021-pol2qm74	6110	17	NF	nf	NN
cord-015021-pol2qm74	6110	18	after	after	IN
cord-015021-pol2qm74	6110	19	ARF	ARF	NNP
cord-015021-pol2qm74	6110	20	remained	remain	VBD
cord-015021-pol2qm74	6110	21	significant	significant	JJ
cord-015021-pol2qm74	6110	22	.	.	.
cord-015021-pol2qm74	6111	1	These	these	DT
cord-015021-pol2qm74	6111	2	results	result	NNS
cord-015021-pol2qm74	6111	3	show	show	VBP
cord-015021-pol2qm74	6111	4	the	the	DT
cord-015021-pol2qm74	6111	5	high	high	JJ
cord-015021-pol2qm74	6111	6	prevalence	prevalence	NN
cord-015021-pol2qm74	6111	7	of	of	IN
cord-015021-pol2qm74	6111	8	ARF	arf	NN
cord-015021-pol2qm74	6111	9	in	in	IN
cord-015021-pol2qm74	6111	10	critically	critically	RB
cord-015021-pol2qm74	6111	11	ill	ill	JJ
cord-015021-pol2qm74	6111	12	patients	patient	NNS
cord-015021-pol2qm74	6111	13	and	and	CC
cord-015021-pol2qm74	6111	14	that	that	IN
cord-015021-pol2qm74	6111	15	ARF	ARF	NNP
cord-015021-pol2qm74	6111	16	rarely	rarely	RB
cord-015021-pol2qm74	6111	17	occurs	occur	VBZ
cord-015021-pol2qm74	6111	18	alone	alone	RB
cord-015021-pol2qm74	6111	19	.	.	.
cord-015021-pol2qm74	6112	1	The	the	DT
cord-015021-pol2qm74	6112	2	prognosis	prognosis	NN
cord-015021-pol2qm74	6112	3	of	of	IN
cord-015021-pol2qm74	6112	4	ARF	ARF	NNP
cord-015021-pol2qm74	6112	5	in	in	IN
cord-015021-pol2qm74	6112	6	critically	critically	RB
cord-015021-pol2qm74	6112	7	ill	ill	JJ
cord-015021-pol2qm74	6112	8	patients	patient	NNS
cord-015021-pol2qm74	6112	9	is	be	VBZ
cord-015021-pol2qm74	6112	10	poor	poor	JJ
cord-015021-pol2qm74	6112	11	,	,	,
cord-015021-pol2qm74	6112	12	especially	especially	RB
cord-015021-pol2qm74	6112	13	if	if	IN
cord-015021-pol2qm74	6112	14	associated	associate	VBN
cord-015021-pol2qm74	6112	15	with	with	IN
cord-015021-pol2qm74	6112	16	advancing	advance	VBG
cord-015021-pol2qm74	6112	17	age	age	NN
cord-015021-pol2qm74	6112	18	,	,	,
cord-015021-pol2qm74	6112	19	additional	additional	JJ
cord-015021-pol2qm74	6112	20	OSF	OSF	NNP
cord-015021-pol2qm74	6112	21	,	,	,
cord-015021-pol2qm74	6112	22	particularly	particularly	RB
cord-015021-pol2qm74	6112	23	cardiopulmonary	cardiopulmonary	JJ
cord-015021-pol2qm74	6112	24	failure	failure	NN
cord-015021-pol2qm74	6112	25	and	and	CC
cord-015021-pol2qm74	6112	26	sepsis	sepsis	NN
cord-015021-pol2qm74	6112	27	before	before	IN
cord-015021-pol2qm74	6112	28	ARF	ARF	NNP
cord-015021-pol2qm74	6112	29	,	,	,
cord-015021-pol2qm74	6112	30	and	and	CC
cord-015021-pol2qm74	6112	31	NF	nf	NN
cord-015021-pol2qm74	6112	32	after	after	IN
cord-015021-pol2qm74	6112	33	ARF	ARF	NNP
cord-015021-pol2qm74	6112	34	.	.	.
cord-015021-pol2qm74	6113	1	Hence	hence	RB
cord-015021-pol2qm74	6113	2	,	,	,
cord-015021-pol2qm74	6113	3	prevention	prevention	NN
cord-015021-pol2qm74	6113	4	of	of	IN
cord-015021-pol2qm74	6113	5	cardiopulmonary	cardiopulmonary	JJ
cord-015021-pol2qm74	6113	6	and	and	CC
cord-015021-pol2qm74	6113	7	sepsis	sepsis	NN
cord-015021-pol2qm74	6113	8	before	before	IN
cord-015021-pol2qm74	6113	9	the	the	DT
cord-015021-pol2qm74	6113	10	outset	outset	NN
cord-015021-pol2qm74	6113	11	of	of	IN
cord-015021-pol2qm74	6113	12	ARF	ARF	NNP
cord-015021-pol2qm74	6113	13	may	may	MD
cord-015021-pol2qm74	6113	14	influence	influence	VB
cord-015021-pol2qm74	6113	15	outcome	outcome	NN
cord-015021-pol2qm74	6113	16	in	in	IN
cord-015021-pol2qm74	6113	17	ARF	arf	NN
cord-015021-pol2qm74	6113	18	in	in	IN
cord-015021-pol2qm74	6113	19	patients	patient	NNS
cord-015021-pol2qm74	6113	20	with	with	IN
cord-015021-pol2qm74	6113	21	critical	critical	JJ
cord-015021-pol2qm74	6113	22	illness	illness	NN
cord-015021-pol2qm74	6113	23	.	.	.
cord-015021-pol2qm74	6114	1	The	the	DT
cord-015021-pol2qm74	6114	2	search	search	NN
cord-015021-pol2qm74	6114	3	cominnes	cominne	NNS
cord-015021-pol2qm74	6114	4	for	for	IN
cord-015021-pol2qm74	6114	5	a	a	DT
cord-015021-pol2qm74	6114	6	magic	magic	JJ
cord-015021-pol2qm74	6114	7	bullet	bullet	NN
cord-015021-pol2qm74	6114	8	ta	ta	PRP
cord-015021-pol2qm74	6114	9	help	help	VB
cord-015021-pol2qm74	6114	10	critically	critically	RB
cord-015021-pol2qm74	6114	11	ill	ill	JJ
cord-015021-pol2qm74	6114	12	petienta	petienta	NNS
cord-015021-pol2qm74	6114	13	,	,	,
cord-015021-pol2qm74	6114	14	bat	bat	VB
cord-015021-pol2qm74	6114	15	recent	recent	JJ
cord-015021-pol2qm74	6114	16	elini	elini	NN
cord-015021-pol2qm74	6114	17	'	'	''
cord-015021-pol2qm74	6114	18	,	,	.
cord-015021-pol2qm74	6115	1	.ml	.ml	.
cord-015021-pol2qm74	6116	1	1rials	1rials	CD
cord-015021-pol2qm74	6116	2	of	of	IN
cord-015021-pol2qm74	6116	3	agents	agent	NNS
cord-015021-pol2qm74	6116	4	that	that	WDT
cord-015021-pol2qm74	6116	5	showed	show	VBD
cord-015021-pol2qm74	6116	6	Ixomise	Ixomise	NNP
cord-015021-pol2qm74	6116	7	in	in	IN
cord-015021-pol2qm74	6116	8	animal	animal	NN
cord-015021-pol2qm74	6116	9	studies	study	NNS
cord-015021-pol2qm74	6116	10	raise	raise	VBP
cord-015021-pol2qm74	6116	11	questions	question	NNS
cord-015021-pol2qm74	6116	12	about	about	IN
cord-015021-pol2qm74	6116	13	such	such	JJ
cord-015021-pol2qm74	6116	14	trials	trial	NNS
cord-015021-pol2qm74	6116	15	.	.	.
cord-015021-pol2qm74	6117	1	ExpcrlmemaI	ExpcrlmemaI	NNP
cord-015021-pol2qm74	6118	1	uvidan~	uvidan~	NN
cord-015021-pol2qm74	6118	2	:	:	:
cord-015021-pol2qm74	6119	1	in	in	IN
cord-015021-pol2qm74	6119	2	anlmats	anlmat	NNS
cord-015021-pol2qm74	6119	3	and	and	CC
cord-015021-pol2qm74	6119	4	human	human	JJ
cord-015021-pol2qm74	6119	5	volanteet~	volanteet~	NN
cord-015021-pol2qm74	6119	6	for	for	IN
cord-015021-pol2qm74	6119	7	concepts	concept	NNS
cord-015021-pol2qm74	6119	8	,	,	,
cord-015021-pol2qm74	6119	9	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6119	10	and	and	CC
cord-015021-pol2qm74	6119	11	treatment	treatment	NN
cord-015021-pol2qm74	6119	12	of	of	IN
cord-015021-pol2qm74	6119	13	inju~	inju~	NN
cord-015021-pol2qm74	6119	14	ur	ur	JJ
cord-015021-pol2qm74	6119	15	illness	illness	NN
cord-015021-pol2qm74	6119	16	can	can	MD
cord-015021-pol2qm74	6119	17	be	be	VB
cord-015021-pol2qm74	6119	18	substentlal	substentlal	NN
cord-015021-pol2qm74	6119	19	,	,	.
cord-015021-pol2qm74	6120	1	l	l	NNP
cord-015021-pol2qm74	6120	2	~	~	CD
cord-015021-pol2qm74	6120	3	rauasive	rauasive	NN
cord-015021-pol2qm74	6120	4	and	and	CC
cord-015021-pol2qm74	6120	5	exciting	exciting	JJ
cord-015021-pol2qm74	6120	6	but	but	CC
cord-015021-pol2qm74	6120	7	the	the	DT
cord-015021-pol2qm74	6120	8	positive	positive	JJ
cord-015021-pol2qm74	6120	9	effects	effect	NNS
cord-015021-pol2qm74	6120	10	of	of	IN
cord-015021-pol2qm74	6120	11	potential	potential	JJ
cord-015021-pol2qm74	6120	12	therapy	therapy	NN
cord-015021-pol2qm74	6120	13	suggested	suggest	VBN
cord-015021-pol2qm74	6120	14	by	by	IN
cord-015021-pol2qm74	6120	15	such	such	JJ
cord-015021-pol2qm74	6120	16	animal	animal	NN
cord-015021-pol2qm74	6120	17	and	and	CC
cord-015021-pol2qm74	6120	18	ctinieal	ctinieal	JJ
cord-015021-pol2qm74	6120	19	research	research	NN
cord-015021-pol2qm74	6120	20	may	may	MD
cord-015021-pol2qm74	6120	21	be	be	VB
cord-015021-pol2qm74	6120	22	difficult	difficult	JJ
cord-015021-pol2qm74	6120	23	to	to	TO
cord-015021-pol2qm74	6120	24	prove	prove	VB
cord-015021-pol2qm74	6120	25	in	in	IN
cord-015021-pol2qm74	6120	26	sick	sick	JJ
cord-015021-pol2qm74	6120	27	patients	patient	NNS
cord-015021-pol2qm74	6120	28	.	.	.
cord-015021-pol2qm74	6121	1	Efficacy	efficacy	NN
cord-015021-pol2qm74	6121	2	of	of	IN
cord-015021-pol2qm74	6121	3	a	a	DT
cord-015021-pol2qm74	6121	4	new	new	JJ
cord-015021-pol2qm74	6121	5	txeatment	txeatment	NN
cord-015021-pol2qm74	6121	6	can	can	MD
cord-015021-pol2qm74	6121	7	be	be	VB
cord-015021-pol2qm74	6121	8	difficult	difficult	JJ
cord-015021-pol2qm74	6121	9	to	to	TO
cord-015021-pol2qm74	6121	10	prove	prove	VB
cord-015021-pol2qm74	6121	11	became	become	VBN
cord-015021-pol2qm74	6121	12	elinie.al	elinie.al	CD
cord-015021-pol2qm74	6121	13	situations	situation	NNS
cord-015021-pol2qm74	6121	14	,	,	,
cord-015021-pol2qm74	6121	15	hi	hi	UH
cord-015021-pol2qm74	6121	16	spi	spi	NNP
cord-015021-pol2qm74	6121	17	~	~	NNP
cord-015021-pol2qm74	6121	18	e	e	NNP
cord-015021-pol2qm74	6121	19	of	of	IN
cord-015021-pol2qm74	6121	20	important	important	JJ
cord-015021-pol2qm74	6121	21	biologic	biologic	JJ
cord-015021-pol2qm74	6121	22	phenomena	phenomenon	NNS
cord-015021-pol2qm74	6121	23	,	,	,
cord-015021-pol2qm74	6121	24	are	be	VBP
cord-015021-pol2qm74	6121	25	v	v	LS
cord-015021-pol2qm74	6121	26	~	~	NFP
cord-015021-pol2qm74	6121	27	iable	iable	NNP
cord-015021-pol2qm74	6121	28	and	and	CC
cord-015021-pol2qm74	6121	29	conrplex	conrplex	NNP
cord-015021-pol2qm74	6121	30	.	.	.
cord-015021-pol2qm74	6122	1	There	there	EX
cord-015021-pol2qm74	6122	2	is	be	VBZ
cord-015021-pol2qm74	6122	3	redundancy	redundancy	NN
cord-015021-pol2qm74	6122	4	and	and	CC
cord-015021-pol2qm74	6122	5	overlap	overlap	NN
cord-015021-pol2qm74	6122	6	of	of	IN
cord-015021-pol2qm74	6122	7	mediators	mediator	NNS
cord-015021-pol2qm74	6123	1	~d	~d	.
cord-015021-pol2qm74	6124	1	problems	problem	NNS
cord-015021-pol2qm74	6124	2	of	of	IN
cord-015021-pol2qm74	6124	3	timing	timing	NN
cord-015021-pol2qm74	6124	4	of	of	IN
cord-015021-pol2qm74	6124	5	therapy	therapy	NN
cord-015021-pol2qm74	6124	6	.	.	.
cord-015021-pol2qm74	6125	1	A	a	DT
cord-015021-pol2qm74	6125	2	majt	majt	NN
cord-015021-pol2qm74	6125	3	~	~	NFP
cord-015021-pol2qm74	6125	4	r	r	NN
cord-015021-pol2qm74	6125	5	cause	cause	NN
cord-015021-pol2qm74	6125	6	of	of	IN
cord-015021-pol2qm74	6125	7	this	this	DT
cord-015021-pol2qm74	6125	8	dilemtns	dilemtns	NN
cord-015021-pol2qm74	6125	9	is	be	VBZ
cord-015021-pol2qm74	6125	10	not	not	RB
cord-015021-pol2qm74	6125	11	with	with	IN
cord-015021-pol2qm74	6125	12	the	the	DT
cord-015021-pol2qm74	6125	13	trials	trial	NNS
cord-015021-pol2qm74	6125	14	or	or	CC
cord-015021-pol2qm74	6125	15	hypotheses	hypothesis	NNS
cord-015021-pol2qm74	6125	16	,	,	,
cord-015021-pol2qm74	6125	17	but	but	CC
cord-015021-pol2qm74	6125	18	rather	rather	RB
cord-015021-pol2qm74	6125	19	the	the	DT
cord-015021-pol2qm74	6125	20	proMem	promem	NN
cord-015021-pol2qm74	6125	21	of	of	IN
cord-015021-pol2qm74	6125	22	the	the	DT
cord-015021-pol2qm74	6125	23	cause	cause	NN
cord-015021-pol2qm74	6125	24	or	or	CC
cord-015021-pol2qm74	6125	25	the	the	DT
cord-015021-pol2qm74	6125	26	causability	causability	NN
cord-015021-pol2qm74	6125	27	of	of	IN
cord-015021-pol2qm74	6125	28	the	the	DT
cord-015021-pol2qm74	6125	29	human	human	JJ
cord-015021-pol2qm74	6125	30	dise~.se	dise~.se	NNS
cord-015021-pol2qm74	6125	31	that	that	WDT
cord-015021-pol2qm74	6125	32	is	be	VBZ
cord-015021-pol2qm74	6125	33	trebled	treble	VBN
cord-015021-pol2qm74	6125	34	.	.	.
cord-015021-pol2qm74	6126	1	This	this	DT
cord-015021-pol2qm74	6126	2	is	be	VBZ
cord-015021-pol2qm74	6126	3	/	/	SYM
cord-015021-pol2qm74	6126	4	hu	hu	NNP
cord-015021-pol2qm74	6126	5	"	"	``
cord-015021-pol2qm74	6126	6	causa	causa	NNP
cord-015021-pol2qm74	6126	7	nets	net	NNS
cord-015021-pol2qm74	6126	8	"	"	''
cord-015021-pol2qm74	6126	9	or	or	CC
cord-015021-pol2qm74	6126	10	'	'	``
cord-015021-pol2qm74	6126	11	*	*	NFP
cord-015021-pol2qm74	6126	12	specific	specific	JJ
cord-015021-pol2qm74	6126	13	cause	cause	NN
cord-015021-pol2qm74	6126	14	"	"	''
cord-015021-pol2qm74	6126	15	as	as	IN
cord-015021-pol2qm74	6126	16	described	describe	VBN
cord-015021-pol2qm74	6126	17	by	by	IN
cord-015021-pol2qm74	6126	18	Stehbens	Stehbens	NNP
cord-015021-pol2qm74	6126	19	,	,	,
cord-015021-pol2qm74	6126	20	When	when	WRB
cord-015021-pol2qm74	6126	21	prevention	prevention	NN
cord-015021-pol2qm74	6126	22	or	or	CC
cord-015021-pol2qm74	6126	23	tre.atmcnt	tre.atmcnt	NNP
cord-015021-pol2qm74	6126	24	is	be	VBZ
cord-015021-pol2qm74	6126	25	based	base	VBN
cord-015021-pol2qm74	6126	26	em	-PRON-	PRP
cord-015021-pol2qm74	6127	1	the	the	DT
cord-015021-pol2qm74	6127	2	sauna	sauna	NN
cord-015021-pol2qm74	6127	3	nero	nero	NNP
cord-015021-pol2qm74	6127	4	,	,	,
cord-015021-pol2qm74	6127	5	extinetiem	extinetiem	NNP
cord-015021-pol2qm74	6127	6	of	of	IN
cord-015021-pol2qm74	6127	7	the	the	DT
cord-015021-pol2qm74	6127	8	disease	disease	NN
cord-015021-pol2qm74	6127	9	is	be	VBZ
cord-015021-pol2qm74	6127	10	Ix	Ix	NNP
cord-015021-pol2qm74	6128	1	~ssible	~ssible	JJ
cord-015021-pol2qm74	6128	2	as	as	IN
cord-015021-pol2qm74	6128	3	with	with	IN
cord-015021-pol2qm74	6128	4	saul/	saul/	ADD
cord-015021-pol2qm74	6128	5	pox	pox	NN
cord-015021-pol2qm74	6128	6	.	.	.
cord-015021-pol2qm74	6129	1	Only	only	RB
cord-015021-pol2qm74	6129	2	elimination	elimination	NN
cord-015021-pol2qm74	6129	3	of	of	IN
cord-015021-pol2qm74	6129	4	the	the	DT
cord-015021-pol2qm74	6129	5	cause	cause	NN
cord-015021-pol2qm74	6129	6	wl12	wl12	NNP
cord-015021-pol2qm74	6129	7	cure	cure	VB
cord-015021-pol2qm74	6129	8	the	the	DT
cord-015021-pol2qm74	6129	9	disease	disease	NN
cord-015021-pol2qm74	6129	10	.	.	.
cord-015021-pol2qm74	6130	1	Careful	careful	JJ
cord-015021-pol2qm74	6130	2	animal	animal	NN
cord-015021-pol2qm74	6130	3	studit	studit	NNP
cord-015021-pol2qm74	6130	4	~	~	NFP
cord-015021-pol2qm74	6130	5	s	s	PRP
cord-015021-pol2qm74	6130	6	evaluate	evaluate	VB
cord-015021-pol2qm74	6130	7	single	single	JJ
cord-015021-pol2qm74	6130	8	pcrturbmiuns	pcrturbmiun	NNS
cord-015021-pol2qm74	6130	9	for	for	IN
cord-015021-pol2qm74	6130	10	survival	survival	NN
cord-015021-pol2qm74	6130	11	or	or	CC
cord-015021-pol2qm74	6130	12	other	other	JJ
cord-015021-pol2qm74	6130	13	changes	change	NNS
cord-015021-pol2qm74	6130	14	.	.	.
cord-015021-pol2qm74	6131	1	An	an	DT
cord-015021-pol2qm74	6131	2	LDso	LDso	NNP
cord-015021-pol2qm74	6131	3	preparation	preparation	NN
cord-015021-pol2qm74	6131	4	may	may	MD
cord-015021-pol2qm74	6131	5	be	be	VB
cord-015021-pol2qm74	6131	6	infiuancad	infiuancad	NNP
cord-015021-pol2qm74	6131	7	aignificantly	aignificantly	RB
cord-015021-pol2qm74	6131	8	by	by	IN
cord-015021-pol2qm74	6131	9	a	a	DT
cord-015021-pol2qm74	6131	10	~mall	~mall	NNP
cord-015021-pol2qm74	6131	11	clangs	clang	NNS
cord-015021-pol2qm74	6131	12	which	which	WDT
cord-015021-pol2qm74	6131	13	may	may	MD
cord-015021-pol2qm74	6131	14	be	be	VB
cord-015021-pol2qm74	6131	15	insignific	insignific	JJ
cord-015021-pol2qm74	6132	1	~lt	~lt	NNP
cord-015021-pol2qm74	6132	2	ht	ht	NNP
cord-015021-pol2qm74	6132	3	pstiants	pstiants	NNP
cord-015021-pol2qm74	6132	4	,	,	,
cord-015021-pol2qm74	6132	5	Most	Most	JJS
cord-015021-pol2qm74	6132	6	human	human	JJ
cord-015021-pol2qm74	6132	7	experiments	experiment	NNS
cord-015021-pol2qm74	6132	8	ate	eat	VBD
cord-015021-pol2qm74	6132	9	carried	carry	VBN
cord-015021-pol2qm74	6132	10	out	out	RP
cord-015021-pol2qm74	6132	11	in	in	IN
cord-015021-pol2qm74	6132	12	normal	normal	JJ
cord-015021-pol2qm74	6132	13	volunleers	volunleer	NNS
cord-015021-pol2qm74	6132	14	with	with	IN
cord-015021-pol2qm74	6132	15	a	a	DT
cord-015021-pol2qm74	6132	16	single	single	JJ
cord-015021-pol2qm74	6132	17	porlurbation	porlurbation	NN
cord-015021-pol2qm74	6132	18	,	,	,
cord-015021-pol2qm74	6132	19	such	such	JJ
cord-015021-pol2qm74	6132	20	as	as	IN
cord-015021-pol2qm74	6132	21	a	a	DT
cord-015021-pol2qm74	6132	22	low	low	JJ
cord-015021-pol2qm74	6132	23	-	-	HYPH
cord-015021-pol2qm74	6132	24	level	level	NN
cord-015021-pol2qm74	6132	25	,	,	,
cord-015021-pol2qm74	6132	26	non	non	JJ
cord-015021-pol2qm74	6132	27	-	-	JJ
cord-015021-pol2qm74	6132	28	lethal	lethal	JJ
cord-015021-pol2qm74	6132	29	dose	dose	NN
cord-015021-pol2qm74	6132	30	of	of	IN
cord-015021-pol2qm74	6132	31	a	a	DT
cord-015021-pol2qm74	6132	32	substance	substance	NN
cord-015021-pol2qm74	6132	33	.	.	.
cord-015021-pol2qm74	6133	1	Such	such	JJ
cord-015021-pol2qm74	6133	2	studies	study	NNS
cord-015021-pol2qm74	6133	3	are	be	VBP
cord-015021-pol2qm74	6133	4	huportant	huportant	JJ
cord-015021-pol2qm74	6133	5	in	in	IN
cord-015021-pol2qm74	6133	6	defining	define	VBG
cord-015021-pol2qm74	6133	7	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6133	8	attd	attd	NN
cord-015021-pol2qm74	6133	9	mediators	mediator	NNS
cord-015021-pol2qm74	6133	10	of	of	IN
cord-015021-pol2qm74	6133	11	disease	disease	NN
cord-015021-pol2qm74	6133	12	,	,	,
cord-015021-pol2qm74	6133	13	In	in	IN
cord-015021-pol2qm74	6133	14	our	-PRON-	PRP$
cord-015021-pol2qm74	6133	15	world	world	NN
cord-015021-pol2qm74	6133	16	of	of	IN
cord-015021-pol2qm74	6133	17	injm'ed	injm'ed	NN
cord-015021-pol2qm74	6133	18	,	,	,
cord-015021-pol2qm74	6133	19	operated	operate	VBN
cord-015021-pol2qm74	6133	20	,	,	,
cord-015021-pol2qm74	6133	21	infected	infected	JJ
cord-015021-pol2qm74	6133	22	and	and	CC
cord-015021-pol2qm74	6133	23	inflslned	inflslned	JJ
cord-015021-pol2qm74	6133	24	patients	patient	NNS
cord-015021-pol2qm74	6133	25	,	,	,
cord-015021-pol2qm74	6133	26	there	there	EX
cord-015021-pol2qm74	6133	27	are	be	VBP
cord-015021-pol2qm74	6133	28	many	many	JJ
cord-015021-pol2qm74	6133	29	diseases	disease	NNS
cord-015021-pol2qm74	6133	30	,	,	,
cord-015021-pol2qm74	6133	31	MOF	MOF	NNP
cord-015021-pol2qm74	6133	32	is	be	VBZ
cord-015021-pol2qm74	6133	33	not	not	RB
cord-015021-pol2qm74	6133	34	one	one	CD
cord-015021-pol2qm74	6133	35	of	of	IN
cord-015021-pol2qm74	6133	36	lhem	lhem	NN
cord-015021-pol2qm74	6133	37	.	.	.
cord-015021-pol2qm74	6134	1	it	-PRON-	PRP
cord-015021-pol2qm74	6134	2	is	be	VBZ
cord-015021-pol2qm74	6134	3	n't	not	RB
cord-015021-pol2qm74	6134	4	even	even	RB
cord-015021-pol2qm74	6134	5	a	a	DT
cord-015021-pol2qm74	6134	6	syndrume	syndrume	NN
cord-015021-pol2qm74	6134	7	,	,	,
cord-015021-pol2qm74	6134	8	It	-PRON-	PRP
cord-015021-pol2qm74	6134	9	is	be	VBZ
cord-015021-pol2qm74	6134	10	the	the	DT
cord-015021-pol2qm74	6134	11	final	final	JJ
cord-015021-pol2qm74	6134	12	pathway	pathway	NN
cord-015021-pol2qm74	6134	13	for	for	IN
cord-015021-pol2qm74	6134	14	a	a	DT
cord-015021-pol2qm74	6134	15	number	number	NN
cord-015021-pol2qm74	6134	16	of	of	IN
cord-015021-pol2qm74	6134	17	diseaaes~	diseaaes~	NNP
cord-015021-pol2qm74	6134	18	each	each	DT
cord-015021-pol2qm74	6134	19	of	of	IN
cord-015021-pol2qm74	6134	20	which	which	WDT
cord-015021-pol2qm74	6134	21	has	have	VBZ
cord-015021-pol2qm74	6134	22	a	a	DT
cord-015021-pol2qm74	6134	23	cause	cause	NN
cord-015021-pol2qm74	6134	24	.	.	.
cord-015021-pol2qm74	6135	1	MeCormock	MeCormock	NNP
cord-015021-pol2qm74	6135	2	believes	believe	VBZ
cord-015021-pol2qm74	6135	3	thal	thal	NNP
cord-015021-pol2qm74	6135	4	a	a	DT
cord-015021-pol2qm74	6135	5	"	"	``
cord-015021-pol2qm74	6135	6	multi	multi	JJ
cord-015021-pol2qm74	6135	7	-	-	JJ
cord-015021-pol2qm74	6135	8	causal	causal	JJ
cord-015021-pol2qm74	6135	9	"	"	''
cord-015021-pol2qm74	6135	10	etiology	etiology	NN
cord-015021-pol2qm74	6135	11	is	be	VBZ
cord-015021-pol2qm74	6135	12	a	a	DT
cord-015021-pol2qm74	6135	13	euphemism	euphemism	NN
cord-015021-pol2qm74	6135	14	for	for	IN
cord-015021-pol2qm74	6135	15	ignoranc	ignoranc	NNP
cord-015021-pol2qm74	6135	16	#	#	NN
cord-015021-pol2qm74	6135	17	or	or	CC
cord-015021-pol2qm74	6135	18	a	a	DT
cord-015021-pol2qm74	6135	19	synonym	synonym	JJ
cord-015021-pol2qm74	6135	20	fo~	fo~	NN
cord-015021-pol2qm74	6135	21	unknown	unknown	JJ
cord-015021-pol2qm74	6135	22	etiology	etiology	NN
cord-015021-pol2qm74	6135	23	.	.	.
cord-015021-pol2qm74	6136	1	Admission	admission	NN
cord-015021-pol2qm74	6136	2	Iv	Iv	NNP
cord-015021-pol2qm74	6136	3	sn	sn	NNP
cord-015021-pol2qm74	6136	4	ICU	ICU	NNP
cord-015021-pol2qm74	6136	5	,	,	,
cord-015021-pol2qm74	6136	6	a	a	DT
cord-015021-pol2qm74	6136	7	high	high	JJ
cord-015021-pol2qm74	6136	8	APACHE	apache	NN
cord-015021-pol2qm74	6136	9	seer%	seer%	,
cord-015021-pol2qm74	6136	10	the	the	DT
cord-015021-pol2qm74	6136	11	sepsis	sepsis	NN
cord-015021-pol2qm74	6136	12	syndrome	syndrome	NN
cord-015021-pol2qm74	6136	13	,	,	,
cord-015021-pol2qm74	6136	14	MOF	MOF	NNP
cord-015021-pol2qm74	6136	15	,	,	,
cord-015021-pol2qm74	6136	16	MUDS	MUDS	NNPS
cord-015021-pol2qm74	6136	17	,	,	,
cord-015021-pol2qm74	6136	18	or	or	CC
cord-015021-pol2qm74	6136	19	SIRS	SIRS	NNP
cord-015021-pol2qm74	6136	20	and	and	CC
cord-015021-pol2qm74	6136	21	having	have	VBG
cord-015021-pol2qm74	6136	22	predictors	predictor	NNS
cord-015021-pol2qm74	6136	23	indicating	indicate	VBG
cord-015021-pol2qm74	6136	24	potential	potential	JJ
cord-015021-pol2qm74	6136	25	mortality	mortality	NN
cord-015021-pol2qm74	6136	26	,	,	,
cord-015021-pol2qm74	6136	27	are	be	VBP
cord-015021-pol2qm74	6136	28	not	not	RB
cord-015021-pol2qm74	6136	29	diseases	disease	NNS
cord-015021-pol2qm74	6136	30	.	.	.
cord-015021-pol2qm74	6137	1	The	the	DT
cord-015021-pol2qm74	6137	2	inmpors	inmpor	NNS
cord-015021-pol2qm74	6137	3	are	be	VBP
cord-015021-pol2qm74	6137	4	getting	get	VBG
cord-015021-pol2qm74	6137	5	negative	negative	JJ
cord-015021-pol2qm74	6137	6	results	result	NNS
cord-015021-pol2qm74	6137	7	in	in	IN
cord-015021-pol2qm74	6137	8	trials	trial	NNS
cord-015021-pol2qm74	6137	9	of	of	IN
cord-015021-pol2qm74	6137	10	agents	agent	NNS
cord-015021-pol2qm74	6137	11	on	on	IN
cord-015021-pol2qm74	6137	12	eiek	eiek	NNP
cord-015021-pol2qm74	6137	13	or	or	CC
cord-015021-pol2qm74	6137	14	septic	septic	JJ
cord-015021-pol2qm74	6137	15	ICU	ICU	NNP
cord-015021-pol2qm74	6137	16	patients	patient	NNS
cord-015021-pol2qm74	6137	17	and	and	CC
cord-015021-pol2qm74	6137	18	aru	aru	NNP
cord-015021-pol2qm74	6137	19	now	now	RB
cord-015021-pol2qm74	6137	20	becoming	become	VBG
cord-015021-pol2qm74	6137	21	splitters	splitter	NNS
cord-015021-pol2qm74	6137	22	,	,	,
cord-015021-pol2qm74	6137	23	dafining	dafine	VBG
cord-015021-pol2qm74	6137	24	subgaoups	subgaoups	NNP
cord-015021-pol2qm74	6137	25	at	at	IN
cord-015021-pol2qm74	6137	26	higher	high	JJR
cord-015021-pol2qm74	6137	27	risk	risk	NN
cord-015021-pol2qm74	6137	28	for	for	IN
cord-015021-pol2qm74	6137	29	death	death	NN
cord-015021-pol2qm74	6137	30	.	.	.
cord-015021-pol2qm74	6138	1	Such	such	JJ
cord-015021-pol2qm74	6138	2	an	an	DT
cord-015021-pol2qm74	6138	3	approach	approach	NN
cord-015021-pol2qm74	6138	4	may	may	MD
cord-015021-pol2qm74	6138	5	produce	produce	VB
cord-015021-pol2qm74	6138	6	positive	positive	JJ
cord-015021-pol2qm74	6138	7	results	result	NNS
cord-015021-pol2qm74	6138	8	if	if	IN
cord-015021-pol2qm74	6138	9	the	the	DT
cord-015021-pol2qm74	6138	10	diseases	disease	NNS
cord-015021-pol2qm74	6138	11	are	be	VBP
cord-015021-pol2qm74	6138	12	identified	identify	VBN
cord-015021-pol2qm74	6138	13	and	and	CC
cord-015021-pol2qm74	6138	14	the	the	DT
cord-015021-pol2qm74	6138	15	treatmeul	treatmeul	NN
cord-015021-pol2qm74	6138	16	is	be	VBZ
cord-015021-pol2qm74	6138	17	specific	specific	JJ
cord-015021-pol2qm74	6138	18	for	for	IN
cord-015021-pol2qm74	6138	19	them	-PRON-	PRP
cord-015021-pol2qm74	6138	20	,	,	,
cord-015021-pol2qm74	6138	21	A	a	DT
cord-015021-pol2qm74	6138	22	major	major	JJ
cord-015021-pol2qm74	6138	23	challenge	challenge	NN
cord-015021-pol2qm74	6138	24	in	in	IN
cord-015021-pol2qm74	6138	25	deterraintng	deterraintng	NN
cord-015021-pol2qm74	6138	26	the	the	DT
cord-015021-pol2qm74	6138	27	efficacy	efficacy	NN
cord-015021-pol2qm74	6138	28	of	of	IN
cord-015021-pol2qm74	6138	29	new	new	JJ
cord-015021-pol2qm74	6138	30	therapies	therapy	NNS
cord-015021-pol2qm74	6138	31	for	for	IN
cord-015021-pol2qm74	6138	32	sepsis	sepsis	NN
cord-015021-pol2qm74	6138	33	nnd	nnd	NNP
cord-015021-pol2qm74	6138	34	shock	shock	NN
cord-015021-pol2qm74	6138	35	Is	be	VBZ
cord-015021-pol2qm74	6138	36	Identifying	identify	VBG
cord-015021-pol2qm74	6138	37	patients	patient	NNS
cord-015021-pol2qm74	6138	38	whose	whose	WP$
cord-015021-pol2qm74	6138	39	e#temtc	e#temtc	CD
cord-015021-pol2qm74	6138	40	Inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6138	41	response	response	NN
cord-015021-pol2qm74	6138	42	Is	be	VBZ
cord-015021-pol2qm74	6138	43	appropriate	appropriate	JJ
cord-015021-pol2qm74	6138	44	from	from	IN
cord-015021-pol2qm74	6138	45	those	those	DT
cord-015021-pol2qm74	6138	46	in	in	IN
cord-015021-pol2qm74	6138	47	whom	whom	WP
cord-015021-pol2qm74	6138	48	the	the	DT
cord-015021-pol2qm74	6138	49	mediator|	mediator|	NNP
cord-015021-pol2qm74	6138	50	are	be	VBP
cord-015021-pol2qm74	6138	51	contributing	contribute	VBG
cord-015021-pol2qm74	6138	52	to	to	TO
cord-015021-pol2qm74	6138	53	end	end	VB
cord-015021-pol2qm74	6138	54	organ	organ	NN
cord-015021-pol2qm74	6138	55	system	system	NN
cord-015021-pol2qm74	6138	56	damage	damage	NN
cord-015021-pol2qm74	6138	57	end	end	NN
cord-015021-pol2qm74	6138	58	death	death	NN
cord-015021-pol2qm74	6138	59	,	,	,
cord-015021-pol2qm74	6138	60	Traditional	Traditional	NNP
cord-015021-pol2qm74	6138	61	and	and	CC
cord-015021-pol2qm74	6138	62	recently	recently	RB
cord-015021-pol2qm74	6138	63	revised	revise	VBD
cord-015021-pol2qm74	6138	64	categorical	categorical	JJ
cord-015021-pol2qm74	6138	65	patient	patient	NN
cord-015021-pol2qm74	6138	66	descriptions	description	NNS
cord-015021-pol2qm74	6138	67	such	such	JJ
cord-015021-pol2qm74	6138	68	as	as	IN
cord-015021-pol2qm74	6138	69	sepsis	sepsis	NN
cord-015021-pol2qm74	6138	70	syndrome	syndrome	NN
cord-015021-pol2qm74	6138	71	,	,	,
cord-015021-pol2qm74	6139	1	sepsis	sepsis	NNP
cord-015021-pol2qm74	6139	2	syndrome	syndrome	NN
cord-015021-pol2qm74	6139	3	with	with	IN
cord-015021-pol2qm74	6139	4	shock	shock	NN
cord-015021-pol2qm74	6139	5	,	,	,
cord-015021-pol2qm74	6139	6	multiple	multiple	JJ
cord-015021-pol2qm74	6139	7	organ	organ	NN
cord-015021-pol2qm74	6139	8	system	system	NN
cord-015021-pol2qm74	6139	9	failure	failure	NN
cord-015021-pol2qm74	6139	10	,	,	,
cord-015021-pol2qm74	6139	11	or	or	CC
cord-015021-pol2qm74	6139	12	the	the	DT
cord-015021-pol2qm74	6139	13	recently	recently	RB
cord-015021-pol2qm74	6139	14	proposed	propose	VBN
cord-015021-pol2qm74	6139	15	systemic	systemic	JJ
cord-015021-pol2qm74	6139	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6139	17	response	response	NN
cord-015021-pol2qm74	6139	18	syndrome	syndrome	NN
cord-015021-pol2qm74	6139	19	(	(	-LRB-
cord-015021-pol2qm74	6139	20	SIRS	SIRS	NNP
cord-015021-pol2qm74	6139	21	)	)	-RRB-
cord-015021-pol2qm74	6139	22	may	may	MD
cord-015021-pol2qm74	6139	23	not	not	RB
cord-015021-pol2qm74	6139	24	be	be	VB
cord-015021-pol2qm74	6139	25	sufilcient	sufilcient	JJ
cord-015021-pol2qm74	6139	26	since	since	IN
cord-015021-pol2qm74	6139	27	they	-PRON-	PRP
cord-015021-pol2qm74	6139	28	Identify	identify	VBP
cord-015021-pol2qm74	6139	29	individuals	individual	NNS
cord-015021-pol2qm74	6139	30	at	at	IN
cord-015021-pol2qm74	6139	31	varying	vary	VBG
cord-015021-pol2qm74	6139	32	levels	level	NNS
cord-015021-pol2qm74	6139	33	of	of	IN
cord-015021-pol2qm74	6139	34	risk	risk	NN
cord-015021-pol2qm74	6139	35	for	for	IN
cord-015021-pol2qm74	6139	36	short	short	JJ
cord-015021-pol2qm74	6139	37	term	term	NN
cord-015021-pol2qm74	6139	38	mortality	mortality	NN
cord-015021-pol2qm74	6139	39	,	,	,
cord-015021-pol2qm74	6139	40	The	the	DT
cord-015021-pol2qm74	6139	41	efficacy	efficacy	NN
cord-015021-pol2qm74	6139	42	of	of	IN
cord-015021-pol2qm74	6139	43	new	new	JJ
cord-015021-pol2qm74	6139	44	lmmunotherapy	lmmunotherapy	NNP
cord-015021-pol2qm74	6139	45	may	may	MD
cord-015021-pol2qm74	6139	46	be	be	VB
cord-015021-pol2qm74	6139	47	directly	directly	RB
cord-015021-pol2qm74	6139	48	related	relate	VBN
cord-015021-pol2qm74	6139	49	to	to	IN
cord-015021-pol2qm74	6139	50	the	the	DT
cord-015021-pol2qm74	6139	51	patient	patient	NN
cord-015021-pol2qm74	6139	52	's	's	POS
cord-015021-pol2qm74	6139	53	severity	severity	NN
cord-015021-pol2qm74	6139	54	end	end	VB
cord-015021-pol2qm74	6139	55	risk	risk	NN
cord-015021-pol2qm74	6139	56	of	of	IN
cord-015021-pol2qm74	6139	57	mortality	mortality	NN
cord-015021-pol2qm74	6139	58	at	at	IN
cord-015021-pol2qm74	6139	59	entry	entry	NN
cord-015021-pol2qm74	6139	60	to	to	IN
cord-015021-pol2qm74	6139	61	the	the	DT
cord-015021-pol2qm74	6139	62	study	study	NN
cord-015021-pol2qm74	6139	63	.	.	.
cord-015021-pol2qm74	6140	1	We	-PRON-	PRP
cord-015021-pol2qm74	6140	2	recently	recently	RB
cord-015021-pol2qm74	6140	3	reported	report	VBD
cord-015021-pol2qm74	6140	4	(	(	-LRB-
cord-015021-pol2qm74	6140	5	JAMA	JAMA	NNP
cord-015021-pol2qm74	6140	6	1993;270:1Z33	1993;270:1z33	CD
cord-015021-pol2qm74	6140	7	-	-	HYPH
cord-015021-pol2qm74	6140	8	1~41	1~41	CD
cord-015021-pol2qm74	6140	9	)	)	-RRB-
cord-015021-pol2qm74	6140	10	a	a	DT
cord-015021-pol2qm74	6140	11	comprehensive	comprehensive	JJ
cord-015021-pol2qm74	6140	12	risk	risk	NN
cord-015021-pol2qm74	6140	13	assessment	assessment	NN
cord-015021-pol2qm74	6140	14	approach	approach	NN
cord-015021-pol2qm74	6140	15	for	for	IN
cord-015021-pol2qm74	6140	16	patients	patient	NNS
cord-015021-pol2qm74	6140	17	with	with	IN
cord-015021-pol2qm74	6140	18	sepsis	sepsis	NN
cord-015021-pol2qm74	6140	19	syndrome	syndrome	NN
cord-015021-pol2qm74	6140	20	,	,	,
cord-015021-pol2qm74	6140	21	a	a	DT
cord-015021-pol2qm74	6140	22	common	common	JJ
cord-015021-pol2qm74	6140	23	eategarlcal	eategarlcal	JJ
cord-015021-pol2qm74	6140	24	description	description	NN
cord-015021-pol2qm74	6140	25	used	use	VBN
cord-015021-pol2qm74	6140	26	as	as	IN
cord-015021-pol2qm74	6140	27	an	an	DT
cord-015021-pol2qm74	6140	28	entry	entry	NN
cord-015021-pol2qm74	6140	29	eriterlon	eriterlon	NN
cord-015021-pol2qm74	6140	30	for	for	IN
cord-015021-pol2qm74	6140	31	many	many	JJ
cord-015021-pol2qm74	6140	32	trials	trial	NNS
cord-015021-pol2qm74	6140	33	.	.	.
cord-015021-pol2qm74	6141	1	By	by	IN
cord-015021-pol2qm74	6141	2	screening	screen	VBG
cord-015021-pol2qm74	6141	3	s	s	POS
cord-015021-pol2qm74	6141	4	database	database	NN
cord-015021-pol2qm74	6141	5	of	of	IN
cord-015021-pol2qm74	6141	6	58,737	58,737	CD
cord-015021-pol2qm74	6141	7	recent	recent	JJ
cord-015021-pol2qm74	6141	8	admissions	admission	NNS
cord-015021-pol2qm74	6141	9	to	to	IN
cord-015021-pol2qm74	6141	10	107	107	CD
cord-015021-pol2qm74	6141	11	hospitals	hospital	NNS
cord-015021-pol2qm74	6141	12	in	in	IN
cord-015021-pol2qm74	6141	13	the	the	DT
cord-015021-pol2qm74	6141	14	United	United	NNP
cord-015021-pol2qm74	6141	15	States	States	NNP
cord-015021-pol2qm74	6141	16	and	and	CC
cord-015021-pol2qm74	6141	17	Western	Western	NNP
cord-015021-pol2qm74	6141	18	Europe	Europe	NNP
cord-015021-pol2qm74	6141	19	,	,	,
cord-015021-pol2qm74	6141	20	we	-PRON-	PRP
cord-015021-pol2qm74	6141	21	identified	identify	VBD
cord-015021-pol2qm74	6141	22	1,195	1,195	CD
cord-015021-pol2qm74	6141	23	patients	patient	NNS
cord-015021-pol2qm74	6141	24	who	who	WP
cord-015021-pol2qm74	6141	25	met	meet	VBD
cord-015021-pol2qm74	6141	26	sepsis	sepsis	NN
cord-015021-pol2qm74	6141	27	syndrome	syndrome	NN
cord-015021-pol2qm74	6141	28	criteria	criterion	NNS
cord-015021-pol2qm74	6141	29	but	but	CC
cord-015021-pol2qm74	6141	30	were	be	VBD
cord-015021-pol2qm74	6141	31	not	not	RB
cord-015021-pol2qm74	6141	32	enrolled	enrol	VBN
cord-015021-pol2qm74	6141	33	tn	tn	NNP
cord-015021-pol2qm74	6141	34	clinical	clinical	JJ
cord-015021-pol2qm74	6141	35	trinh	trinh	NNP
cord-015021-pol2qm74	6141	36	,	,	,
cord-015021-pol2qm74	6141	37	We	-PRON-	PRP
cord-015021-pol2qm74	6141	38	then	then	RB
cord-015021-pol2qm74	6141	39	developed	develop	VBD
cord-015021-pol2qm74	6141	40	a	a	DT
cord-015021-pol2qm74	6141	41	survival	survival	NN
cord-015021-pol2qm74	6141	42	model	model	NN
cord-015021-pol2qm74	6141	43	end	end	NN
cord-015021-pol2qm74	6141	44	severlty	severlty	NN
cord-015021-pol2qm74	6141	45	assessment	assessment	NN
cord-015021-pol2qm74	6141	46	method	method	NN
cord-015021-pol2qm74	6141	47	to	to	TO
cord-015021-pol2qm74	6141	48	estimate	estimate	VB
cord-015021-pol2qm74	6141	49	their	-PRON-	PRP$
cord-015021-pol2qm74	6141	50	2g.day	2g.day	CD
cord-015021-pol2qm74	6141	51	mortality	mortality	NN
cord-015021-pol2qm74	6141	52	risk	risk	NN
cord-015021-pol2qm74	6141	53	.	.	.
cord-015021-pol2qm74	6142	1	k	k	NNP
cord-015021-pol2qm74	6142	2	..	..	.
cord-015021-pol2qm74	6143	1	ente	ente	NNP
cord-015021-pol2qm74	6143	2	physiologic	physiologic	JJ
cord-015021-pol2qm74	6143	3	abnormalities	abnormality	NNS
cord-015021-pol2qm74	6143	4	were	be	VBD
cord-015021-pol2qm74	6143	5	the	the	DT
cord-015021-pol2qm74	6143	6	most	most	RBS
cord-015021-pol2qm74	6143	7	important	important	JJ
cord-015021-pol2qm74	6143	8	prognostic	prognostic	JJ
cord-015021-pol2qm74	6143	9	factors	factor	NNS
cord-015021-pol2qm74	6143	10	(	(	-LRB-
cord-015021-pol2qm74	6143	11	82	82	CD
cord-015021-pol2qm74	6143	12	%	%	NN
cord-015021-pol2qm74	6143	13	of	of	IN
cord-015021-pol2qm74	6143	14	total	total	JJ
cord-015021-pol2qm74	6143	15	chl	chl	NNP
cord-015021-pol2qm74	6143	16	square	square	NNP
cord-015021-pol2qm74	6143	17	)	)	-RRB-
cord-015021-pol2qm74	6143	18	influencing	influence	VBG
cord-015021-pol2qm74	6143	19	outcome	outcome	NN
cord-015021-pol2qm74	6143	20	.	.	.
cord-015021-pol2qm74	6144	1	The	the	DT
cord-015021-pol2qm74	6144	2	specific	specific	JJ
cord-015021-pol2qm74	6144	3	disease	disease	NN
cord-015021-pol2qm74	6144	4	resulting	result	VBG
cord-015021-pol2qm74	6144	5	in	in	IN
cord-015021-pol2qm74	6144	6	Ice	Ice	NNP
cord-015021-pol2qm74	6144	7	admission	admission	NN
cord-015021-pol2qm74	6144	8	and	and	CC
cord-015021-pol2qm74	6144	9	the	the	DT
cord-015021-pol2qm74	6144	10	days	day	NNS
cord-015021-pol2qm74	6144	11	the	the	DT
cord-015021-pol2qm74	6144	12	patient	patient	NN
cord-015021-pol2qm74	6144	13	spent	spend	VBN
cord-015021-pol2qm74	6144	14	In	in	IN
cord-015021-pol2qm74	6144	15	the	the	DT
cord-015021-pol2qm74	6144	16	hospital	hospital	NN
cord-015021-pol2qm74	6144	17	and	and	CC
cord-015021-pol2qm74	6144	18	ICU	ICU	NNP
cord-015021-pol2qm74	6144	19	before	before	IN
cord-015021-pol2qm74	6144	20	qualification	qualification	NN
cord-015021-pol2qm74	6144	21	were	be	VBD
cord-015021-pol2qm74	6144	22	independent	independent	JJ
cord-015021-pol2qm74	6144	23	risks	risk	NNS
cord-015021-pol2qm74	6144	24	,	,	,
cord-015021-pol2qm74	6144	25	as	as	IN
cord-015021-pol2qm74	6144	26	were	be	VBD
cord-015021-pol2qm74	6144	27	age	age	NN
cord-015021-pol2qm74	6144	28	and	and	CC
cord-015021-pol2qm74	6144	29	a	a	DT
cord-015021-pol2qm74	6144	30	clinical	clinical	JJ
cord-015021-pol2qm74	6144	31	history	history	NN
cord-015021-pol2qm74	6144	32	of	of	IN
cord-015021-pol2qm74	6144	33	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	6144	34	.	.	.
cord-015021-pol2qm74	6145	1	The	the	DT
cord-015021-pol2qm74	6145	2	predictive	predictive	JJ
cord-015021-pol2qm74	6145	3	model	model	NN
cord-015021-pol2qm74	6145	4	was	be	VBD
cord-015021-pol2qm74	6145	5	cross	cross	JJ
cord-015021-pol2qm74	6145	6	-	-	VBN
cord-015021-pol2qm74	6145	7	validated	validate	VBN
cord-015021-pol2qm74	6145	8	within	within	IN
cord-015021-pol2qm74	6145	9	the	the	DT
cord-015021-pol2qm74	6145	10	original	original	JJ
cord-015021-pol2qm74	6145	11	1,195	1,195	CD
cord-015021-pol2qm74	6145	12	patients	patient	NNS
cord-015021-pol2qm74	6145	13	with	with	IN
cord-015021-pol2qm74	6145	14	a	a	DT
cord-015021-pol2qm74	6145	15	Receiver	Receiver	NNP
cord-015021-pol2qm74	6145	16	D_perator	D_perator	NNP
cord-015021-pol2qm74	6145	17	Characteristics	Characteristics	NNP
cord-015021-pol2qm74	6145	18	(	(	-LRB-
cord-015021-pol2qm74	6145	19	ROC	ROC	NNP
cord-015021-pol2qm74	6145	20	)	)	-RRB-
cord-015021-pol2qm74	6145	21	area	area	NN
cord-015021-pol2qm74	6145	22	of	of	IN
cord-015021-pol2qm74	6145	23	0.76	0.76	CD
cord-015021-pol2qm74	6145	24	and	and	CC
cord-015021-pol2qm74	6146	1	In	in	IN
cord-015021-pol2qm74	6146	2	two	two	CD
cord-015021-pol2qm74	6146	3	Independent	independent	JJ
cord-015021-pol2qm74	6146	4	databases	database	NNS
cord-015021-pol2qm74	6146	5	,	,	,
cord-015021-pol2qm74	6146	6	The	the	DT
cord-015021-pol2qm74	6146	7	first	first	JJ
cord-015021-pol2qm74	6146	8	independent	independent	JJ
cord-015021-pol2qm74	6146	9	database	database	NN
cord-015021-pol2qm74	6146	10	contained	contain	VBD
cord-015021-pol2qm74	6146	11	295	295	CD
cord-015021-pol2qm74	6146	12	hospitalized	hospitalize	VBN
cord-015021-pol2qm74	6146	13	patients	patient	NNS
cord-015021-pol2qm74	6146	14	with	with	IN
cord-015021-pol2qm74	6146	15	gram	gram	JJ
cord-015021-pol2qm74	6146	16	-	-	HYPH
cord-015021-pol2qm74	6146	17	negative	negative	JJ
cord-015021-pol2qm74	6146	18	infection	infection	NN
cord-015021-pol2qm74	6146	19	meeting	meeting	NN
cord-015021-pol2qm74	6146	20	criteria	criterion	NNS
cord-015021-pol2qm74	6146	21	for	for	IN
cord-015021-pol2qm74	6146	22	sepsis	sepsis	NN
cord-015021-pol2qm74	6146	23	syndrome	syndrome	NN
cord-015021-pol2qm74	6146	24	(	(	-LRB-
cord-015021-pol2qm74	6146	25	ROC=0.80	ROC=0.80	NNP
cord-015021-pol2qm74	6146	26	)	)	-RRB-
cord-015021-pol2qm74	6146	27	;	;	:
cord-015021-pol2qm74	6146	28	in	in	IN
cord-015021-pol2qm74	6146	29	the	the	DT
cord-015021-pol2qm74	6146	30	second	second	JJ
cord-015021-pol2qm74	6146	31	,	,	,
cord-015021-pol2qm74	6146	32	the	the	DT
cord-015021-pol2qm74	6146	33	302	302	CD
cord-015021-pol2qm74	6146	34	placebo	placebo	NN
cord-015021-pol2qm74	6146	35	patients	patient	NNS
cord-015021-pol2qm74	6146	36	withtn	withtn	NNP
cord-015021-pol2qm74	6146	37	the	the	DT
cord-015021-pol2qm74	6146	38	recently	recently	RB
cord-015021-pol2qm74	6146	39	completed	complete	VBN
cord-015021-pol2qm74	6146	40	Phase	phase	NN
cord-015021-pol2qm74	6146	41	Ill	Ill	NNP
cord-015021-pol2qm74	6146	42	e	e	NN
cord-015021-pol2qm74	6147	1	~aluatlan	~aluatlan	NNP
cord-015021-pol2qm74	6147	2	of	of	IN
cord-015021-pol2qm74	6147	3	IL-1Ra	IL-1Ra	NNP
cord-015021-pol2qm74	6147	4	(	(	-LRB-
cord-015021-pol2qm74	6147	5	ROCffi0.76	ROCffi0.76	NNP
cord-015021-pol2qm74	6147	6	)	)	-RRB-
cord-015021-pol2qm74	6147	7	.	.	.
cord-015021-pol2qm74	6148	1	In	in	IN
cord-015021-pol2qm74	6148	2	all	all	DT
cord-015021-pol2qm74	6148	3	databases	database	NNS
cord-015021-pol2qm74	6148	4	the	the	DT
cord-015021-pol2qm74	6148	5	risk	risk	NN
cord-015021-pol2qm74	6148	6	model	model	NN
cord-015021-pol2qm74	6148	7	was	be	VBD
cord-015021-pol2qm74	6148	8	able	able	JJ
cord-015021-pol2qm74	6148	9	to	to	TO
cord-015021-pol2qm74	6148	10	accurately	accurately	RB
cord-015021-pol2qm74	6148	11	risk	risk	VB
cord-015021-pol2qm74	6148	12	stratify	stratify	VB
cord-015021-pol2qm74	6148	13	patients	patient	NNS
cord-015021-pol2qm74	6148	14	throughout	throughout	IN
cord-015021-pol2qm74	6148	15	the	the	DT
cord-015021-pol2qm74	6148	16	range	range	NN
cord-015021-pol2qm74	6148	17	of	of	IN
cord-015021-pol2qm74	6148	18	risks	risk	NNS
cord-015021-pol2qm74	6148	19	that	that	WDT
cord-015021-pol2qm74	6148	20	varled	varle	VBD
cord-015021-pol2qm74	6148	21	from	from	IN
cord-015021-pol2qm74	6148	22	a	a	DT
cord-015021-pol2qm74	6148	23	very	very	RB
cord-015021-pol2qm74	6148	24	low	low	JJ
cord-015021-pol2qm74	6148	25	1	1	CD
cord-015021-pol2qm74	6148	26	%	%	NN
cord-015021-pol2qm74	6148	27	to	to	IN
cord-015021-pol2qm74	6148	28	a	a	DT
cord-015021-pol2qm74	6148	29	very	very	JJ
cord-015021-pol2qm74	6148	30	hlglt	hlglt	NNP
cord-015021-pol2qm74	6148	31	99	99	CD
cord-015021-pol2qm74	6148	32	%	%	NN
cord-015021-pol2qm74	6148	33	.	.	.
cord-015021-pol2qm74	6149	1	By	by	IN
cord-015021-pol2qm74	6149	2	drawing	draw	VBG
cord-015021-pol2qm74	6149	3	on	on	IN
cord-015021-pol2qm74	6149	4	the	the	DT
cord-015021-pol2qm74	6149	5	ready	ready	JJ
cord-015021-pol2qm74	6149	6	avatlabillty	avatlabillty	NN
cord-015021-pol2qm74	6149	7	of	of	IN
cord-015021-pol2qm74	6149	8	large	large	JJ
cord-015021-pol2qm74	6149	9	clinically	clinically	RB
cord-015021-pol2qm74	6149	10	aeuurate	aeuurate	NN
cord-015021-pol2qm74	6149	11	,	,	,
cord-015021-pol2qm74	6149	12	current	current	JJ
cord-015021-pol2qm74	6149	13	databases	database	NNS
cord-015021-pol2qm74	6149	14	and	and	CC
cord-015021-pol2qm74	6149	15	using	use	VBG
cord-015021-pol2qm74	6149	16	the	the	DT
cord-015021-pol2qm74	6149	17	power	power	NN
cord-015021-pol2qm74	6149	18	of	of	IN
cord-015021-pol2qm74	6149	19	modern	modern	JJ
cord-015021-pol2qm74	6149	20	statistical	statistical	JJ
cord-015021-pol2qm74	6149	21	techniques	technique	NNS
cord-015021-pol2qm74	6149	22	to	to	TO
cord-015021-pol2qm74	6149	23	model	model	VB
cord-015021-pol2qm74	6149	24	the	the	DT
cord-015021-pol2qm74	6149	25	bodfs	bodfs	NNP
cord-015021-pol2qm74	6149	26	response	response	NN
cord-015021-pol2qm74	6149	27	to	to	IN
cord-015021-pol2qm74	6149	28	sepsis	sepsis	NN
cord-015021-pol2qm74	6149	29	,	,	,
cord-015021-pol2qm74	6149	30	we	-PRON-	PRP
cord-015021-pol2qm74	6149	31	are	be	VBP
cord-015021-pol2qm74	6149	32	able	able	JJ
cord-015021-pol2qm74	6149	33	to	to	TO
cord-015021-pol2qm74	6149	34	produce	produce	VB
cord-015021-pol2qm74	6149	35	very	very	RB
cord-015021-pol2qm74	6149	36	aeettrate	aeettrate	JJ
cord-015021-pol2qm74	6149	37	pre	pre	JJ
cord-015021-pol2qm74	6149	38	-	-	JJ
cord-015021-pol2qm74	6149	39	treatment	treatment	JJ
cord-015021-pol2qm74	6149	40	risk	risk	NN
cord-015021-pol2qm74	6149	41	estimates	estimate	NNS
cord-015021-pol2qm74	6149	42	,	,	,
cord-015021-pol2qm74	6149	43	These	these	DT
cord-015021-pol2qm74	6149	44	prospectively	prospectively	RB
cord-015021-pol2qm74	6149	45	defined	define	VBN
cord-015021-pol2qm74	6149	46	and	and	CC
cord-015021-pol2qm74	6149	47	continuous	continuous	JJ
cord-015021-pol2qm74	6149	48	risk	risk	NN
cord-015021-pol2qm74	6149	49	estimates	estimate	NNS
cord-015021-pol2qm74	6149	50	reduce	reduce	VBP
cord-015021-pol2qm74	6149	51	reliance	reliance	NN
cord-015021-pol2qm74	6149	52	on	on	IN
cord-015021-pol2qm74	6149	53	multiple	multiple	JJ
cord-015021-pol2qm74	6149	54	subgroups	subgroup	NNS
cord-015021-pol2qm74	6149	55	and	and	CC
cord-015021-pol2qm74	6149	56	data	datum	NNS
cord-015021-pol2qm74	6149	57	dredging	dredging	NN
cord-015021-pol2qm74	6149	58	that	that	WDT
cord-015021-pol2qm74	6149	59	can	can	MD
cord-015021-pol2qm74	6149	60	compromise	compromise	VB
cord-015021-pol2qm74	6149	61	a	a	DT
cord-015021-pol2qm74	6149	62	stady	stady	NNP
cord-015021-pol2qm74	6149	63	's	's	POS
cord-015021-pol2qm74	6149	64	integrity	integrity	NN
cord-015021-pol2qm74	6149	65	.	.	.
cord-015021-pol2qm74	6150	1	They	-PRON-	PRP
cord-015021-pol2qm74	6150	2	cart	cart	VBP
cord-015021-pol2qm74	6150	3	provide	provide	VBP
cord-015021-pol2qm74	6150	4	a	a	DT
cord-015021-pol2qm74	6150	5	nnlform	nnlform	NN
cord-015021-pol2qm74	6150	6	method	method	NN
cord-015021-pol2qm74	6150	7	for	for	IN
cord-015021-pol2qm74	6150	8	patient	patient	JJ
cord-015021-pol2qm74	6150	9	description	description	NN
cord-015021-pol2qm74	6150	10	across	across	IN
cord-015021-pol2qm74	6150	11	clinical	clinical	JJ
cord-015021-pol2qm74	6150	12	trials	trial	NNS
cord-015021-pol2qm74	6150	13	of	of	IN
cord-015021-pol2qm74	6150	14	different	different	JJ
cord-015021-pol2qm74	6150	15	attempts	attempt	NNS
cord-015021-pol2qm74	6150	16	at	at	IN
cord-015021-pol2qm74	6150	17	immmlotherapy	immmlotherapy	NNP
cord-015021-pol2qm74	6150	18	.	.	.
cord-015021-pol2qm74	6151	1	Risk	risk	NN
cord-015021-pol2qm74	6151	2	calculations	calculation	NNS
cord-015021-pol2qm74	6151	3	can	can	MD
cord-015021-pol2qm74	6151	4	also	also	RB
cord-015021-pol2qm74	6151	5	be	be	VB
cord-015021-pol2qm74	6151	6	useful	useful	JJ
cord-015021-pol2qm74	6151	7	in	in	IN
cord-015021-pol2qm74	6151	8	developing	develop	VBG
cord-015021-pol2qm74	6151	9	entry	entry	NN
cord-015021-pol2qm74	6151	10	criteria	criterion	NNS
cord-015021-pol2qm74	6151	11	for	for	IN
cord-015021-pol2qm74	6151	12	Phase	Phase	NNP
cord-015021-pol2qm74	6151	13	II	II	NNP
cord-015021-pol2qm74	6151	14	evaluations	evaluation	NNS
cord-015021-pol2qm74	6151	15	in	in	IN
cord-015021-pol2qm74	6151	16	order	order	NN
cord-015021-pol2qm74	6151	17	to	to	TO
cord-015021-pol2qm74	6151	18	initially	initially	RB
cord-015021-pol2qm74	6151	19	test	test	VB
cord-015021-pol2qm74	6151	20	efficacy	efficacy	NN
cord-015021-pol2qm74	6151	21	on	on	IN
cord-015021-pol2qm74	6151	22	a	a	DT
cord-015021-pol2qm74	6151	23	limited	limited	JJ
cord-015021-pol2qm74	6151	24	number	number	NN
cord-015021-pol2qm74	6151	25	of	of	IN
cord-015021-pol2qm74	6151	26	high	high	JJ
cord-015021-pol2qm74	6151	27	risk	risk	NN
cord-015021-pol2qm74	6151	28	patients	patient	NNS
cord-015021-pol2qm74	6151	29	,	,	,
cord-015021-pol2qm74	6151	30	Fonowing	Fonowing	NNP
cord-015021-pol2qm74	6151	31	sueeessinl	sueeessinl	NNS
cord-015021-pol2qm74	6151	32	completion	completion	NN
cord-015021-pol2qm74	6151	33	of	of	IN
cord-015021-pol2qm74	6151	34	a	a	DT
cord-015021-pol2qm74	6151	35	definitive	definitive	JJ
cord-015021-pol2qm74	6151	36	trial	trial	NN
cord-015021-pol2qm74	6151	37	,	,	,
cord-015021-pol2qm74	6151	38	the	the	DT
cord-015021-pol2qm74	6151	39	risk	risk	NN
cord-015021-pol2qm74	6151	40	estimates	estimate	NNS
cord-015021-pol2qm74	6151	41	can	can	MD
cord-015021-pol2qm74	6151	42	be	be	VB
cord-015021-pol2qm74	6151	43	used	use	VBN
cord-015021-pol2qm74	6151	44	to	to	TO
cord-015021-pol2qm74	6151	45	develop	develop	VB
cord-015021-pol2qm74	6151	46	specific	specific	JJ
cord-015021-pol2qm74	6151	47	|ndlcattons	|ndlcatton	NNS
cord-015021-pol2qm74	6151	48	for	for	IN
cord-015021-pol2qm74	6151	49	s	s	NNP
cord-015021-pol2qm74	6151	50	drug	drug	NN
cord-015021-pol2qm74	6151	51	's	's	POS
cord-015021-pol2qm74	6151	52	use	use	NN
cord-015021-pol2qm74	6151	53	and	and	CC
cord-015021-pol2qm74	6151	54	can	can	MD
cord-015021-pol2qm74	6151	55	monitor	monitor	VB
cord-015021-pol2qm74	6151	56	the	the	DT
cord-015021-pol2qm74	6151	57	impact	impact	NN
cord-015021-pol2qm74	6151	58	of	of	IN
cord-015021-pol2qm74	6151	59	both	both	CC
cord-015021-pol2qm74	6151	60	new	new	JJ
cord-015021-pol2qm74	6151	61	and	and	CC
cord-015021-pol2qm74	6151	62	multiple	multiple	JJ
cord-015021-pol2qm74	6151	63	compounds	compound	NNS
cord-015021-pol2qm74	6151	64	on	on	IN
cord-015021-pol2qm74	6151	65	patient	patient	NN
cord-015021-pol2qm74	6151	66	outrome	outrome	NN
cord-015021-pol2qm74	6151	67	,	,	,
cord-015021-pol2qm74	6151	68	When	when	WRB
cord-015021-pol2qm74	6151	69	dealing	deal	VBG
cord-015021-pol2qm74	6151	70	with	with	IN
cord-015021-pol2qm74	6151	71	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6151	72	trials	trial	NNS
cord-015021-pol2qm74	6151	73	for	for	IN
cord-015021-pol2qm74	6151	74	the	the	DT
cord-015021-pol2qm74	6151	75	treatment	treatment	NN
cord-015021-pol2qm74	6151	76	of	of	IN
cord-015021-pol2qm74	6151	77	sepsis	sepsis	NN
cord-015021-pol2qm74	6151	78	,	,	,
cord-015021-pol2qm74	6151	79	there	there	EX
cord-015021-pol2qm74	6151	80	are	be	VBP
cord-015021-pol2qm74	6151	81	2	2	CD
cord-015021-pol2qm74	6151	82	ways	way	NNS
cord-015021-pol2qm74	6151	83	of	of	IN
cord-015021-pol2qm74	6151	84	checking	check	VBG
cord-015021-pol2qm74	6151	85	the	the	DT
cord-015021-pol2qm74	6151	86	comparability	comparability	NN
cord-015021-pol2qm74	6151	87	of	of	IN
cord-015021-pol2qm74	6151	88	the	the	DT
cord-015021-pol2qm74	6151	89	groups	group	NNS
cord-015021-pol2qm74	6151	90	(	(	-LRB-
cord-015021-pol2qm74	6151	91	placebo	placebo	NN
cord-015021-pol2qm74	6151	92	and	and	CC
cord-015021-pol2qm74	6151	93	treated	treat	VBN
cord-015021-pol2qm74	6151	94	groups	group	NNS
cord-015021-pol2qm74	6151	95	)	)	-RRB-
cord-015021-pol2qm74	6152	1	-To	-To	:
cord-015021-pol2qm74	6152	2	use	use	VB
cord-015021-pol2qm74	6152	3	several	several	JJ
cord-015021-pol2qm74	6152	4	description	description	NN
cord-015021-pol2qm74	6152	5	items	item	NNS
cord-015021-pol2qm74	6152	6	such	such	JJ
cord-015021-pol2qm74	6152	7	as	as	IN
cord-015021-pol2qm74	6152	8	age	age	NN
cord-015021-pol2qm74	6152	9	,	,	,
cord-015021-pol2qm74	6152	10	sex	sex	NN
cord-015021-pol2qm74	6152	11	,	,	,
cord-015021-pol2qm74	6152	12	preexisting	preexist	VBG
cord-015021-pol2qm74	6152	13	disease	disease	NN
cord-015021-pol2qm74	6152	14	,	,	,
cord-015021-pol2qm74	6152	15	number	number	NN
cord-015021-pol2qm74	6152	16	and	and	CC
cord-015021-pol2qm74	6152	17	nature	nature	NN
cord-015021-pol2qm74	6152	18	of	of	IN
cord-015021-pol2qm74	6152	19	organ	organ	NN
cord-015021-pol2qm74	6152	20	failures	failure	NNS
cord-015021-pol2qm74	6152	21	,	,	,
cord-015021-pol2qm74	6152	22	physiology	physiology	NN
cord-015021-pol2qm74	6152	23	score	score	NN
cord-015021-pol2qm74	6152	24	,	,	,
cord-015021-pol2qm74	6152	25	such	such	JJ
cord-015021-pol2qm74	6152	26	as	as	IN
cord-015021-pol2qm74	6152	27	SAPS	SAPS	NNP
cord-015021-pol2qm74	6152	28	IL	IL	NNP
cord-015021-pol2qm74	6152	29	(	(	-LRB-
cord-015021-pol2qm74	6152	30	1	1	CD
cord-015021-pol2qm74	6152	31	)	)	-RRB-
cord-015021-pol2qm74	6152	32	-To	-To	:
cord-015021-pol2qm74	6152	33	use	use	VBP
cord-015021-pol2qm74	6152	34	a	a	DT
cord-015021-pol2qm74	6152	35	model	model	NN
cord-015021-pol2qm74	6152	36	for	for	IN
cord-015021-pol2qm74	6152	37	risk	risk	NN
cord-015021-pol2qm74	6152	38	of	of	IN
cord-015021-pol2qm74	6152	39	death	death	NN
cord-015021-pol2qm74	6152	40	either	either	CC
cord-015021-pol2qm74	6152	41	from	from	IN
cord-015021-pol2qm74	6152	42	a	a	DT
cord-015021-pol2qm74	6152	43	score	score	NN
cord-015021-pol2qm74	6152	44	(	(	-LRB-
cord-015021-pol2qm74	6152	45	APACHE	APACHE	NNP
cord-015021-pol2qm74	6152	46	II	II	NNP
cord-015021-pol2qm74	6152	47	,	,	,
cord-015021-pol2qm74	6152	48	lII	lII	NNP
cord-015021-pol2qm74	6152	49	,	,	,
cord-015021-pol2qm74	6152	50	(	(	-LRB-
cord-015021-pol2qm74	6152	51	2	2	LS
cord-015021-pol2qm74	6152	52	)	)	-RRB-
cord-015021-pol2qm74	6152	53	SAPS	SAPS	NNP
cord-015021-pol2qm74	6152	54	II	II	NNP
cord-015021-pol2qm74	6152	55	)	)	-RRB-
cord-015021-pol2qm74	6152	56	or	or	CC
cord-015021-pol2qm74	6152	57	directly	directly	RB
cord-015021-pol2qm74	6152	58	(	(	-LRB-
cord-015021-pol2qm74	6152	59	MPM	MPM	NNP
cord-015021-pol2qm74	6152	60	II	II	NNP
cord-015021-pol2qm74	6152	61	system	system	NN
cord-015021-pol2qm74	6152	62	(	(	-LRB-
cord-015021-pol2qm74	6152	63	3	3	CD
cord-015021-pol2qm74	6152	64	)	)	-RRB-
cord-015021-pol2qm74	6152	65	)	)	-RRB-
cord-015021-pol2qm74	6153	1	Before	before	IN
cord-015021-pol2qm74	6153	2	using	use	VBG
cord-015021-pol2qm74	6153	3	the	the	DT
cord-015021-pol2qm74	6153	4	model	model	NN
cord-015021-pol2qm74	6153	5	for	for	IN
cord-015021-pol2qm74	6153	6	risk	risk	NN
cord-015021-pol2qm74	6153	7	of	of	IN
cord-015021-pol2qm74	6153	8	death	death	NN
cord-015021-pol2qm74	6153	9	in	in	IN
cord-015021-pol2qm74	6153	10	septic	septic	JJ
cord-015021-pol2qm74	6153	11	patients	patient	NNS
cord-015021-pol2qm74	6153	12	,	,	,
cord-015021-pol2qm74	6153	13	is	be	VBZ
cord-015021-pol2qm74	6153	14	it	-PRON-	PRP
cord-015021-pol2qm74	6153	15	mandatory	mandatory	JJ
cord-015021-pol2qm74	6153	16	to	to	TO
cord-015021-pol2qm74	6153	17	validate	validate	VB
cord-015021-pol2qm74	6153	18	it	-PRON-	PRP
cord-015021-pol2qm74	6153	19	(	(	-LRB-
cord-015021-pol2qm74	6153	20	by	by	IN
cord-015021-pol2qm74	6153	21	calibration	calibration	NN
cord-015021-pol2qm74	6153	22	,	,	,
cord-015021-pol2qm74	6153	23	i.e.	i.e.	FW
cord-015021-pol2qm74	6153	24	goodness	goodness	NN
cord-015021-pol2qm74	6153	25	of	of	IN
cord-015021-pol2qm74	6153	26	fit	fit	NN
cord-015021-pol2qm74	6153	27	,	,	,
cord-015021-pol2qm74	6153	28	and	and	CC
cord-015021-pol2qm74	6153	29	discrin'dnation	discrin'dnation	NNP
cord-015021-pol2qm74	6153	30	,	,	,
cord-015021-pol2qm74	6153	31	i.e.	i.e.	FW
cord-015021-pol2qm74	6153	32	,	,	,
cord-015021-pol2qm74	6153	33	ROC	ROC	NNP
cord-015021-pol2qm74	6153	34	curves	curve	VBZ
cord-015021-pol2qm74	6153	35	)	)	-RRB-
cord-015021-pol2qm74	6153	36	first	first	RB
cord-015021-pol2qm74	6153	37	on	on	IN
cord-015021-pol2qm74	6153	38	a	a	DT
cord-015021-pol2qm74	6153	39	data	data	NN
cord-015021-pol2qm74	6153	40	base	base	NN
cord-015021-pol2qm74	6153	41	using	use	VBG
cord-015021-pol2qm74	6153	42	the	the	DT
cord-015021-pol2qm74	6153	43	same	same	JJ
cord-015021-pol2qm74	6153	44	definition	definition	NN
cord-015021-pol2qm74	6153	45	for	for	IN
cord-015021-pol2qm74	6153	46	sepsis	sepsis	NN
cord-015021-pol2qm74	6153	47	as	as	IN
cord-015021-pol2qm74	6153	48	in	in	IN
cord-015021-pol2qm74	6153	49	the	the	DT
cord-015021-pol2qm74	6153	50	trial	trial	NN
cord-015021-pol2qm74	6153	51	and	and	CC
cord-015021-pol2qm74	6153	52	secondly	secondly	RB
cord-015021-pol2qm74	6153	53	on	on	IN
cord-015021-pol2qm74	6153	54	the	the	DT
cord-015021-pol2qm74	6153	55	placebo	placebo	NN
cord-015021-pol2qm74	6153	56	group	group	NN
cord-015021-pol2qm74	6153	57	of	of	IN
cord-015021-pol2qm74	6153	58	the	the	DT
cord-015021-pol2qm74	6153	59	trial	trial	NN
cord-015021-pol2qm74	6153	60	?	?	.
cord-015021-pol2qm74	6154	1	or	or	CC
cord-015021-pol2qm74	6154	2	is	be	VBZ
cord-015021-pol2qm74	6154	3	it	-PRON-	PRP
cord-015021-pol2qm74	6154	4	better	well	JJR
cord-015021-pol2qm74	6154	5	to	to	TO
cord-015021-pol2qm74	6154	6	use	use	VB
cord-015021-pol2qm74	6154	7	a	a	DT
cord-015021-pol2qm74	6154	8	specific	specific	JJ
cord-015021-pol2qm74	6154	9	model	model	NN
cord-015021-pol2qm74	6154	10	for	for	IN
cord-015021-pol2qm74	6154	11	each	each	DT
cord-015021-pol2qm74	6154	12	trial	trial	NN
cord-015021-pol2qm74	6154	13	?	?	.
cord-015021-pol2qm74	6155	1	The	the	DT
cord-015021-pol2qm74	6155	2	general	general	JJ
cord-015021-pol2qm74	6155	3	models	model	NNS
cord-015021-pol2qm74	6155	4	usually	usually	RB
cord-015021-pol2qm74	6155	5	do	do	VBP
cord-015021-pol2qm74	6155	6	uot	uot	VBN
cord-015021-pol2qm74	6155	7	fit	fit	VB
cord-015021-pol2qm74	6155	8	for	for	IN
cord-015021-pol2qm74	6155	9	septic	septic	JJ
cord-015021-pol2qm74	6155	10	patients	patient	NNS
cord-015021-pol2qm74	6155	11	.	.	.
cord-015021-pol2qm74	6156	1	There	there	EX
cord-015021-pol2qm74	6156	2	are	be	VBP
cord-015021-pol2qm74	6156	3	2	2	CD
cord-015021-pol2qm74	6156	4	methods	method	NNS
cord-015021-pol2qm74	6156	5	to	to	TO
cord-015021-pol2qm74	6156	6	make	make	VB
cord-015021-pol2qm74	6156	7	them	-PRON-	PRP
cord-015021-pol2qm74	6156	8	fit	fit	JJ
cord-015021-pol2qm74	6156	9	:	:	:
cord-015021-pol2qm74	6156	10	either	either	CC
cord-015021-pol2qm74	6156	11	to	to	TO
cord-015021-pol2qm74	6156	12	add	add	VB
cord-015021-pol2qm74	6156	13	variables	variable	NNS
cord-015021-pol2qm74	6156	14	to	to	IN
cord-015021-pol2qm74	6156	15	the	the	DT
cord-015021-pol2qm74	6156	16	original	original	JJ
cord-015021-pol2qm74	6156	17	score	score	NN
cord-015021-pol2qm74	6156	18	(	(	-LRB-
cord-015021-pol2qm74	6156	19	model	model	NN
cord-015021-pol2qm74	6156	20	for	for	IN
cord-015021-pol2qm74	6156	21	sepsis	sepsis	NN
cord-015021-pol2qm74	6156	22	using	use	VBG
cord-015021-pol2qm74	6156	23	the	the	DT
cord-015021-pol2qm74	6156	24	APACHE	APACHE	NNP
cord-015021-pol2qm74	6156	25	III	III	NNP
cord-015021-pol2qm74	6156	26	system	system	NN
cord-015021-pol2qm74	6156	27	(	(	-LRB-
cord-015021-pol2qm74	6156	28	4	4	CD
cord-015021-pol2qm74	6156	29	)	)	-RRB-
cord-015021-pol2qm74	6156	30	)	)	-RRB-
cord-015021-pol2qm74	6156	31	or	or	CC
cord-015021-pol2qm74	6156	32	to	to	TO
cord-015021-pol2qm74	6156	33	customize	customize	VB
cord-015021-pol2qm74	6156	34	the	the	DT
cord-015021-pol2qm74	6156	35	model	model	NN
cord-015021-pol2qm74	6156	36	.	.	.
cord-015021-pol2qm74	6157	1	For	for	IN
cord-015021-pol2qm74	6157	2	SAPS	SAPS	NNP
cord-015021-pol2qm74	6157	3	II	II	NNP
cord-015021-pol2qm74	6157	4	the	the	DT
cord-015021-pol2qm74	6157	5	customization	customization	NN
cord-015021-pol2qm74	6157	6	is	be	VBZ
cord-015021-pol2qm74	6157	7	applied	apply	VBN
cord-015021-pol2qm74	6157	8	to	to	IN
cord-015021-pol2qm74	6157	9	the	the	DT
cord-015021-pol2qm74	6157	10	equation	equation	NN
cord-015021-pol2qm74	6157	11	regression	regression	NN
cord-015021-pol2qm74	6157	12	,	,	,
cord-015021-pol2qm74	6157	13	using	use	VBG
cord-015021-pol2qm74	6157	14	the	the	DT
cord-015021-pol2qm74	6157	15	same	same	JJ
cord-015021-pol2qm74	6157	16	SAPS	SAPS	NNP
cord-015021-pol2qm74	6157	17	II	II	NNP
cord-015021-pol2qm74	6157	18	score	score	NN
cord-015021-pol2qm74	6157	19	.	.	.
cord-015021-pol2qm74	6158	1	For	for	IN
cord-015021-pol2qm74	6158	2	MPM	MPM	NNP
cord-015021-pol2qm74	6158	3	1I	1i	CD
cord-015021-pol2qm74	6158	4	each	each	DT
cord-015021-pol2qm74	6158	5	component	component	NN
cord-015021-pol2qm74	6158	6	of	of	IN
cord-015021-pol2qm74	6158	7	the	the	DT
cord-015021-pol2qm74	6158	8	model	model	NN
cord-015021-pol2qm74	6158	9	can	can	MD
cord-015021-pol2qm74	6158	10	be	be	VB
cord-015021-pol2qm74	6158	11	customized	customize	VBN
cord-015021-pol2qm74	6158	12	.	.	.
cord-015021-pol2qm74	6159	1	Several	several	JJ
cord-015021-pol2qm74	6159	2	Remarks	remark	NNS
cord-015021-pol2qm74	6159	3	:	:	:
cord-015021-pol2qm74	6159	4	Only	only	RB
cord-015021-pol2qm74	6159	5	one	one	CD
cord-015021-pol2qm74	6159	6	model	model	NN
cord-015021-pol2qm74	6159	7	is	be	VBZ
cord-015021-pol2qm74	6159	8	published	publish	VBN
cord-015021-pol2qm74	6159	9	to	to	TO
cord-015021-pol2qm74	6159	10	be	be	VB
cord-015021-pol2qm74	6159	11	applied	apply	VBN
cord-015021-pol2qm74	6159	12	at	at	IN
cord-015021-pol2qm74	6159	13	the	the	DT
cord-015021-pol2qm74	6159	14	ICU	ICU	NNP
cord-015021-pol2qm74	6159	15	entry	entry	NN
cord-015021-pol2qm74	6159	16	(	(	-LRB-
cord-015021-pol2qm74	6159	17	MPM	MPM	NNP
cord-015021-pol2qm74	6159	18	II	II	NNP
cord-015021-pol2qm74	6159	19	0	0	NFP
cord-015021-pol2qm74	6159	20	)	)	-RRB-
cord-015021-pol2qm74	6159	21	before	before	IN
cord-015021-pol2qm74	6159	22	any	any	DT
cord-015021-pol2qm74	6159	23	therapy	therapy	NN
cord-015021-pol2qm74	6159	24	.	.	.
cord-015021-pol2qm74	6160	1	2	2	LS
cord-015021-pol2qm74	6160	2	-Most	-most	NN
cord-015021-pol2qm74	6160	3	of	of	IN
cord-015021-pol2qm74	6160	4	the	the	DT
cord-015021-pol2qm74	6160	5	published	publish	VBN
cord-015021-pol2qm74	6160	6	scores	score	NNS
cord-015021-pol2qm74	6160	7	are	be	VBP
cord-015021-pol2qm74	6160	8	calculated	calculate	VBN
cord-015021-pol2qm74	6160	9	from	from	IN
cord-015021-pol2qm74	6160	10	the	the	DT
cord-015021-pol2qm74	6160	11	lsl	lsl	NNP
cord-015021-pol2qm74	6160	12	ICU	ICU	NNP
cord-015021-pol2qm74	6160	13	day	day	NN
cord-015021-pol2qm74	6160	14	.	.	.
cord-015021-pol2qm74	6161	1	Applying	apply	VBG
cord-015021-pol2qm74	6161	2	these	these	DT
cord-015021-pol2qm74	6161	3	scores	score	NNS
cord-015021-pol2qm74	6161	4	to	to	IN
cord-015021-pol2qm74	6161	5	the	the	DT
cord-015021-pol2qm74	6161	6	let	let	JJ
cord-015021-pol2qm74	6161	7	day	day	NN
cord-015021-pol2qm74	6161	8	of	of	IN
cord-015021-pol2qm74	6161	9	sepsis	sepsis	NN
cord-015021-pol2qm74	6161	10	could	could	MD
cord-015021-pol2qm74	6161	11	have	have	VB
cord-015021-pol2qm74	6161	12	a	a	DT
cord-015021-pol2qm74	6161	13	very	very	RB
cord-015021-pol2qm74	6161	14	different	different	JJ
cord-015021-pol2qm74	6161	15	significance	significance	NN
cord-015021-pol2qm74	6161	16	.	.	.
cord-015021-pol2qm74	6162	1	3	3	LS
cord-015021-pol2qm74	6162	2	-Is	-i	VBZ
cord-015021-pol2qm74	6162	3	the	the	DT
cord-015021-pol2qm74	6162	4	ACCP	ACCP	NNP
cord-015021-pol2qm74	6162	5	classification	classification	NN
cord-015021-pol2qm74	6162	6	of	of	IN
cord-015021-pol2qm74	6162	7	sepsis	sepsis	NN
cord-015021-pol2qm74	6162	8	useful	useful	JJ
cord-015021-pol2qm74	6162	9	at	at	IN
cord-015021-pol2qm74	6162	10	the	the	DT
cord-015021-pol2qm74	6162	11	bedside	bedside	NN
cord-015021-pol2qm74	6162	12	to	to	TO
cord-015021-pol2qm74	6162	13	select	select	VB
cord-015021-pol2qm74	6162	14	oatients	oatient	NNS
cord-015021-pol2qm74	6162	15	?	?	.
cord-015021-pol2qm74	6163	1	(	(	-LRB-
cord-015021-pol2qm74	6163	2	The	the	DT
cord-015021-pol2qm74	6163	3	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	6163	4	of	of	IN
cord-015021-pol2qm74	6163	5	sepsis	sepsis	NN
cord-015021-pol2qm74	6163	6	involves	involve	VBZ
cord-015021-pol2qm74	6163	7	a	a	DT
cord-015021-pol2qm74	6163	8	dynamic	dynamic	JJ
cord-015021-pol2qm74	6163	9	interaction	interaction	NN
cord-015021-pol2qm74	6163	10	between	between	IN
cord-015021-pol2qm74	6163	11	the	the	DT
cord-015021-pol2qm74	6163	12	host	host	NN
cord-015021-pol2qm74	6163	13	and	and	CC
cord-015021-pol2qm74	6163	14	the	the	DT
cord-015021-pol2qm74	6163	15	infecting	infect	VBG
cord-015021-pol2qm74	6163	16	microorganism(s	microorganism(s	NNP
cord-015021-pol2qm74	6163	17	)	)	-RRB-
cord-015021-pol2qm74	6163	18	.	.	.
cord-015021-pol2qm74	6164	1	A	a	DT
cord-015021-pol2qm74	6164	2	multitude	multitude	NN
cord-015021-pol2qm74	6164	3	of	of	IN
cord-015021-pol2qm74	6164	4	biochemical	biochemical	JJ
cord-015021-pol2qm74	6164	5	and	and	CC
cord-015021-pol2qm74	6164	6	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	6164	7	interactions	interaction	NNS
cord-015021-pol2qm74	6164	8	occur	occur	VBP
cord-015021-pol2qm74	6164	9	which	which	WDT
cord-015021-pol2qm74	6164	10	function	function	VBP
cord-015021-pol2qm74	6164	11	in	in	IN
cord-015021-pol2qm74	6164	12	concert	concert	NN
cord-015021-pol2qm74	6164	13	to	to	TO
cord-015021-pol2qm74	6164	14	determine	determine	VB
cord-015021-pol2qm74	6164	15	the	the	DT
cord-015021-pol2qm74	6164	16	ultimate	ultimate	JJ
cord-015021-pol2qm74	6164	17	outcome	outcome	NN
cord-015021-pol2qm74	6164	18	of	of	IN
cord-015021-pol2qm74	6164	19	the	the	DT
cord-015021-pol2qm74	6164	20	septic	septic	JJ
cord-015021-pol2qm74	6164	21	episode	episode	NN
cord-015021-pol2qm74	6164	22	.	.	.
cord-015021-pol2qm74	6165	1	The	the	DT
cord-015021-pol2qm74	6165	2	complexities	complexity	NNS
cord-015021-pol2qm74	6165	3	of	of	IN
cord-015021-pol2qm74	6165	4	the	the	DT
cord-015021-pol2qm74	6165	5	septic	septic	JJ
cord-015021-pol2qm74	6165	6	process	process	NN
cord-015021-pol2qm74	6165	7	preclude	preclude	VBP
cord-015021-pol2qm74	6165	8	outcome	outcome	NN
cord-015021-pol2qm74	6165	9	analysis	analysis	NN
cord-015021-pol2qm74	6165	10	by	by	IN
cord-015021-pol2qm74	6165	11	in	in	FW
cord-015021-pol2qm74	6165	12	vitro	vitro	FW
cord-015021-pol2qm74	6165	13	systems	system	NNS
cord-015021-pol2qm74	6165	14	or	or	CC
cord-015021-pol2qm74	6165	15	computer	computer	NN
cord-015021-pol2qm74	6165	16	models	model	NNS
cord-015021-pol2qm74	6165	17	,	,	,
cord-015021-pol2qm74	6165	18	Animal	Animal	NNP
cord-015021-pol2qm74	6165	19	studies	study	NNS
cord-015021-pol2qm74	6165	20	have	have	VBP
cord-015021-pol2qm74	6165	21	become	become	VBN
cord-015021-pol2qm74	6165	22	indispensable	indispensable	JJ
cord-015021-pol2qm74	6165	23	in	in	IN
cord-015021-pol2qm74	6165	24	evaluating	evaluate	VBG
cord-015021-pol2qm74	6165	25	new	new	JJ
cord-015021-pol2qm74	6165	26	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6165	27	agents	agent	NNS
cord-015021-pol2qm74	6165	28	in	in	IN
cord-015021-pol2qm74	6165	29	the	the	DT
cord-015021-pol2qm74	6165	30	treatment	treatment	NN
cord-015021-pol2qm74	6165	31	of	of	IN
cord-015021-pol2qm74	6165	32	sepsis	sepsis	NN
cord-015021-pol2qm74	6165	33	.	.	.
cord-015021-pol2qm74	6166	1	These	these	DT
cord-015021-pol2qm74	6166	2	studies	study	NNS
cord-015021-pol2qm74	6166	3	provide	provide	VBP
cord-015021-pol2qm74	6166	4	valuable	valuable	JJ
cord-015021-pol2qm74	6166	5	information	information	NN
cord-015021-pol2qm74	6166	6	on	on	IN
cord-015021-pol2qm74	6166	7	safety	safety	NN
cord-015021-pol2qm74	6166	8	,	,	,
cord-015021-pol2qm74	6166	9	pharmacokinetics	pharmacokinetic	NNS
cord-015021-pol2qm74	6166	10	,	,	,
cord-015021-pol2qm74	6166	11	relative	relative	JJ
cord-015021-pol2qm74	6166	12	efficacy	efficacy	NN
cord-015021-pol2qm74	6166	13	and	and	CC
cord-015021-pol2qm74	6166	14	dosing	dose	VBG
cord-015021-pol2qm74	6166	15	strategies	strategy	NNS
cord-015021-pol2qm74	6166	16	for	for	IN
cord-015021-pol2qm74	6166	17	potential	potential	JJ
cord-015021-pol2qm74	6166	18	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6166	19	agents	agent	NNS
cord-015021-pol2qm74	6166	20	in	in	IN
cord-015021-pol2qm74	6166	21	the	the	DT
cord-015021-pol2qm74	6166	22	treatment	treatment	NN
cord-015021-pol2qm74	6166	23	of	of	IN
cord-015021-pol2qm74	6166	24	sepsis	sepsis	NN
cord-015021-pol2qm74	6166	25	.	.	.
cord-015021-pol2qm74	6167	1	There	there	EX
cord-015021-pol2qm74	6167	2	are	be	VBP
cord-015021-pol2qm74	6167	3	three	three	CD
cord-015021-pol2qm74	6167	4	basic	basic	JJ
cord-015021-pol2qm74	6167	5	types	type	NNS
cord-015021-pol2qm74	6167	6	of	of	IN
cord-015021-pol2qm74	6167	7	animal	animal	NN
cord-015021-pol2qm74	6167	8	models	model	NNS
cord-015021-pol2qm74	6167	9	:	:	:
cord-015021-pol2qm74	6167	10	(	(	-LRB-
cord-015021-pol2qm74	6167	11	1	1	LS
cord-015021-pol2qm74	6167	12	)	)	-RRB-
cord-015021-pol2qm74	6167	13	toxicity	toxicity	NN
cord-015021-pol2qm74	6167	14	models	model	NNS
cord-015021-pol2qm74	6167	15	with	with	IN
cord-015021-pol2qm74	6167	16	injection	injection	NN
cord-015021-pol2qm74	6167	17	of	of	IN
cord-015021-pol2qm74	6167	18	bacterial	bacterial	JJ
cord-015021-pol2qm74	6167	19	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6167	20	or	or	CC
cord-015021-pol2qm74	6167	21	exotoxins	exotoxin	NNS
cord-015021-pol2qm74	6167	22	;	;	,
cord-015021-pol2qm74	6167	23	(	(	-LRB-
cord-015021-pol2qm74	6167	24	2	2	LS
cord-015021-pol2qm74	6167	25	)	)	-RRB-
cord-015021-pol2qm74	6167	26	live	live	VB
cord-015021-pol2qm74	6167	27	or	or	CC
cord-015021-pol2qm74	6167	28	killed	kill	VBD
cord-015021-pol2qm74	6167	29	bacterial	bacterial	JJ
cord-015021-pol2qm74	6167	30	challenge	challenge	NN
cord-015021-pol2qm74	6167	31	models	model	NNS
cord-015021-pol2qm74	6167	32	;	;	,
cord-015021-pol2qm74	6167	33	(	(	-LRB-
cord-015021-pol2qm74	6167	34	3	3	LS
cord-015021-pol2qm74	6167	35	)	)	-RRB-
cord-015021-pol2qm74	6167	36	actual	actual	JJ
cord-015021-pol2qm74	6167	37	infection	infection	NN
cord-015021-pol2qm74	6167	38	models	model	NNS
cord-015021-pol2qm74	6167	39	.	.	.
cord-015021-pol2qm74	6168	1	All	all	DT
cord-015021-pol2qm74	6168	2	models	model	NNS
cord-015021-pol2qm74	6168	3	employ	employ	VBP
cord-015021-pol2qm74	6168	4	some	some	DT
cord-015021-pol2qm74	6168	5	form	form	NN
cord-015021-pol2qm74	6168	6	of	of	IN
cord-015021-pol2qm74	6168	7	external	external	JJ
cord-015021-pol2qm74	6168	8	manipulation	manipulation	NN
cord-015021-pol2qm74	6168	9	under	under	IN
cord-015021-pol2qm74	6168	10	controlled	control	VBN
cord-015021-pol2qm74	6168	11	conditions	condition	NNS
cord-015021-pol2qm74	6168	12	to	to	TO
cord-015021-pol2qm74	6168	13	induce	induce	VB
cord-015021-pol2qm74	6168	14	sepsis	sepsis	NN
cord-015021-pol2qm74	6168	15	and	and	CC
cord-015021-pol2qm74	6168	16	to	to	TO
cord-015021-pol2qm74	6168	17	analyze	analyze	VB
cord-015021-pol2qm74	6168	18	potential	potential	JJ
cord-015021-pol2qm74	6168	19	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6168	20	efficacy	efficacy	NN
cord-015021-pol2qm74	6168	21	.	.	.
cord-015021-pol2qm74	6169	1	These	these	DT
cord-015021-pol2qm74	6169	2	experimental	experimental	JJ
cord-015021-pol2qm74	6169	3	requirements	requirement	NNS
cord-015021-pol2qm74	6169	4	may	may	MD
cord-015021-pol2qm74	6169	5	limit	limit	VB
cord-015021-pol2qm74	6169	6	the	the	DT
cord-015021-pol2qm74	6169	7	ability	ability	NN
cord-015021-pol2qm74	6169	8	of	of	IN
cord-015021-pol2qm74	6169	9	animal	animal	NN
cord-015021-pol2qm74	6169	10	models	model	NNS
cord-015021-pol2qm74	6169	11	to	to	TO
cord-015021-pol2qm74	6169	12	accurately	accurately	RB
cord-015021-pol2qm74	6169	13	predict	predict	VB
cord-015021-pol2qm74	6169	14	the	the	DT
cord-015021-pol2qm74	6169	15	clinical	clinical	JJ
cord-015021-pol2qm74	6169	16	value	value	NN
cord-015021-pol2qm74	6169	17	of	of	IN
cord-015021-pol2qm74	6169	18	new	new	JJ
cord-015021-pol2qm74	6169	19	agents	agent	NNS
cord-015021-pol2qm74	6169	20	in	in	IN
cord-015021-pol2qm74	6169	21	human	human	JJ
cord-015021-pol2qm74	6169	22	sepsis	sepsis	NN
cord-015021-pol2qm74	6169	23	.	.	.
cord-015021-pol2qm74	6170	1	Four	four	CD
cord-015021-pol2qm74	6170	2	major	major	JJ
cord-015021-pol2qm74	6170	3	end	end	NN
cord-015021-pol2qm74	6170	4	points	point	NNS
cord-015021-pol2qm74	6170	5	are	be	VBP
cord-015021-pol2qm74	6170	6	analyzed	analyze	VBN
cord-015021-pol2qm74	6170	7	in	in	IN
cord-015021-pol2qm74	6170	8	the	the	DT
cord-015021-pol2qm74	6170	9	various	various	JJ
cord-015021-pol2qm74	6170	10	animal	animal	NN
cord-015021-pol2qm74	6170	11	models	model	NNS
cord-015021-pol2qm74	6170	12	:	:	:
cord-015021-pol2qm74	6170	13	(	(	-LRB-
cord-015021-pol2qm74	6170	14	1	1	LS
cord-015021-pol2qm74	6170	15	)	)	-RRB-
cord-015021-pol2qm74	6170	16	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	6170	17	parameters	parameter	NNS
cord-015021-pol2qm74	6170	18	;	;	,
cord-015021-pol2qm74	6170	19	(	(	-LRB-
cord-015021-pol2qm74	6170	20	2	2	LS
cord-015021-pol2qm74	6170	21	)	)	-RRB-
cord-015021-pol2qm74	6170	22	modulation	modulation	NN
cord-015021-pol2qm74	6170	23	of	of	IN
cord-015021-pol2qm74	6170	24	host	host	NN
cord-015021-pol2qm74	6170	25	-	-	HYPH
cord-015021-pol2qm74	6170	26	derived	derive	VBN
cord-015021-pol2qm74	6170	27	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6170	28	mediators	mediator	NNS
cord-015021-pol2qm74	6170	29	;	;	,
cord-015021-pol2qm74	6170	30	(	(	-LRB-
cord-015021-pol2qm74	6170	31	3	3	LS
cord-015021-pol2qm74	6170	32	)	)	-RRB-
cord-015021-pol2qm74	6170	33	resolution	resolution	NN
cord-015021-pol2qm74	6170	34	of	of	IN
cord-015021-pol2qm74	6170	35	end	end	JJ
cord-015021-pol2qm74	6170	36	organ	organ	NN
cord-015021-pol2qm74	6170	37	injury	injury	NN
cord-015021-pol2qm74	6170	38	;	;	,
cord-015021-pol2qm74	6170	39	or	or	CC
cord-015021-pol2qm74	6170	40	(	(	-LRB-
cord-015021-pol2qm74	6170	41	4	4	LS
cord-015021-pol2qm74	6170	42	)	)	-RRB-
cord-015021-pol2qm74	6170	43	lethality	lethality	NN
cord-015021-pol2qm74	6170	44	.	.	.
cord-015021-pol2qm74	6171	1	Each	each	DT
cord-015021-pol2qm74	6171	2	animal	animal	NN
cord-015021-pol2qm74	6171	3	model	model	NN
cord-015021-pol2qm74	6171	4	has	have	VBZ
cord-015021-pol2qm74	6171	5	certain	certain	JJ
cord-015021-pol2qm74	6171	6	advantages	advantage	NNS
cord-015021-pol2qm74	6171	7	and	and	CC
cord-015021-pol2qm74	6171	8	limitations	limitation	NNS
cord-015021-pol2qm74	6171	9	.	.	.
cord-015021-pol2qm74	6172	1	Species	species	NN
cord-015021-pol2qm74	6172	2	-	-	HYPH
cord-015021-pol2qm74	6172	3	specific	specific	JJ
cord-015021-pol2qm74	6172	4	differences	difference	NNS
cord-015021-pol2qm74	6172	5	in	in	IN
cord-015021-pol2qm74	6172	6	physiologic	physiologic	JJ
cord-015021-pol2qm74	6172	7	and	and	CC
cord-015021-pol2qm74	6172	8	immunologic	immunologic	JJ
cord-015021-pol2qm74	6172	9	features	feature	NNS
cord-015021-pol2qm74	6172	10	make	make	VBP
cord-015021-pol2qm74	6172	11	it	-PRON-	PRP
cord-015021-pol2qm74	6172	12	difficult	difficult	JJ
cord-015021-pol2qm74	6172	13	to	to	TO
cord-015021-pol2qm74	6172	14	directly	directly	RB
cord-015021-pol2qm74	6172	15	extrapolate	extrapolate	VB
cord-015021-pol2qm74	6172	16	the	the	DT
cord-015021-pol2qm74	6172	17	results	result	NNS
cord-015021-pol2qm74	6172	18	of	of	IN
cord-015021-pol2qm74	6172	19	animal	animal	NN
cord-015021-pol2qm74	6172	20	experiments	experiment	NNS
cord-015021-pol2qm74	6172	21	into	into	IN
cord-015021-pol2qm74	6172	22	clinical	clinical	JJ
cord-015021-pol2qm74	6172	23	medicine	medicine	NN
cord-015021-pol2qm74	6172	24	.	.	.
cord-015021-pol2qm74	6173	1	While	while	IN
cord-015021-pol2qm74	6173	2	no	no	DT
cord-015021-pol2qm74	6173	3	ideal	ideal	JJ
cord-015021-pol2qm74	6173	4	animal	animal	NN
cord-015021-pol2qm74	6173	5	model	model	NN
cord-015021-pol2qm74	6173	6	exists	exist	VBZ
cord-015021-pol2qm74	6173	7	,	,	,
cord-015021-pol2qm74	6173	8	consistent	consistent	JJ
cord-015021-pol2qm74	6173	9	benefit	benefit	NN
cord-015021-pol2qm74	6173	10	of	of	IN
cord-015021-pol2qm74	6173	11	a	a	DT
cord-015021-pol2qm74	6173	12	new	new	JJ
cord-015021-pol2qm74	6173	13	immunotherapeutic	immunotherapeutic	JJ
cord-015021-pol2qm74	6173	14	agent	agent	NN
cord-015021-pol2qm74	6173	15	in	in	IN
cord-015021-pol2qm74	6173	16	multiple	multiple	JJ
cord-015021-pol2qm74	6173	17	animal	animal	NN
cord-015021-pol2qm74	6173	18	systems	system	NNS
cord-015021-pol2qm74	6173	19	provides	provide	VBZ
cord-015021-pol2qm74	6173	20	the	the	DT
cord-015021-pol2qm74	6173	21	most	most	RBS
cord-015021-pol2qm74	6173	22	compelling	compelling	JJ
cord-015021-pol2qm74	6173	23	preclinical	preclinical	JJ
cord-015021-pol2qm74	6173	24	evidence	evidence	NN
cord-015021-pol2qm74	6173	25	of	of	IN
cord-015021-pol2qm74	6173	26	its	-PRON-	PRP$
cord-015021-pol2qm74	6173	27	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6173	28	potential	potential	NN
cord-015021-pol2qm74	6173	29	in	in	IN
cord-015021-pol2qm74	6173	30	septic	septic	JJ
cord-015021-pol2qm74	6173	31	patients	patient	NNS
cord-015021-pol2qm74	6173	32	.	.	.
cord-015021-pol2qm74	6174	1	Consensus	consensus	NN
cord-015021-pol2qm74	6174	2	-	-	HYPH
cord-015021-pol2qm74	6174	3	assisted	assist	VBN
cord-015021-pol2qm74	6174	4	development	development	NN
cord-015021-pol2qm74	6174	5	of	of	IN
cord-015021-pol2qm74	6174	6	a	a	DT
cord-015021-pol2qm74	6174	7	study	study	NN
cord-015021-pol2qm74	6174	8	protocol	protocol	NN
cord-015021-pol2qm74	6174	9	on	on	IN
cord-015021-pol2qm74	6174	10	sepsis	sepsis	NN
cord-015021-pol2qm74	6174	11	:	:	:
cord-015021-pol2qm74	6174	12	an	an	DT
cord-015021-pol2qm74	6174	13	important	important	JJ
cord-015021-pol2qm74	6174	14	difference	difference	NN
cord-015021-pol2qm74	6174	15	from	from	IN
cord-015021-pol2qm74	6174	16	previous	previous	JJ
cord-015021-pol2qm74	6174	17	randomized	randomized	JJ
cord-015021-pol2qm74	6174	18	trials	trial	NNS
cord-015021-pol2qm74	6174	19	There	there	EX
cord-015021-pol2qm74	6174	20	have	have	VBP
cord-015021-pol2qm74	6174	21	been	be	VBN
cord-015021-pol2qm74	6174	22	several	several	JJ
cord-015021-pol2qm74	6174	23	,	,	,
cord-015021-pol2qm74	6174	24	and	and	CC
cord-015021-pol2qm74	6174	25	perhaps	perhaps	RB
cord-015021-pol2qm74	6174	26	too	too	RB
cord-015021-pol2qm74	6174	27	many	many	JJ
cord-015021-pol2qm74	6174	28	metaanalyses	metaanalyse	NNS
cord-015021-pol2qm74	6174	29	of	of	IN
cord-015021-pol2qm74	6174	30	cliuical	cliuical	JJ
cord-015021-pol2qm74	6174	31	trials	trial	NNS
cord-015021-pol2qm74	6174	32	on	on	IN
cord-015021-pol2qm74	6174	33	surgical	surgical	JJ
cord-015021-pol2qm74	6174	34	infections	infection	NNS
cord-015021-pol2qm74	6174	35	,	,	,
cord-015021-pol2qm74	6174	36	but	but	CC
cord-015021-pol2qm74	6174	37	their	-PRON-	PRP$
cord-015021-pol2qm74	6174	38	results	result	NNS
cord-015021-pol2qm74	6174	39	have	have	VBP
cord-015021-pol2qm74	6174	40	only	only	RB
cord-015021-pol2qm74	6174	41	rarely	rarely	RB
cord-015021-pol2qm74	6174	42	been	be	VBN
cord-015021-pol2qm74	6174	43	incorporated	incorporate	VBN
cord-015021-pol2qm74	6174	44	into	into	IN
cord-015021-pol2qm74	6174	45	the	the	DT
cord-015021-pol2qm74	6174	46	design	design	NN
cord-015021-pol2qm74	6174	47	of	of	IN
cord-015021-pol2qm74	6174	48	new	new	JJ
cord-015021-pol2qm74	6174	49	randomized	randomized	JJ
cord-015021-pol2qm74	6174	50	trials	trial	NNS
cord-015021-pol2qm74	6174	51	in	in	IN
cord-015021-pol2qm74	6174	52	sepsis	sepsis	NN
cord-015021-pol2qm74	6174	53	.	.	.
cord-015021-pol2qm74	6175	1	Metaanalysis	Metaanalysis	NNP
cord-015021-pol2qm74	6175	2	is	be	VBZ
cord-015021-pol2qm74	6175	3	retrospective	retrospective	JJ
cord-015021-pol2qm74	6175	4	.	.	.
cord-015021-pol2qm74	6176	1	It	-PRON-	PRP
cord-015021-pol2qm74	6176	2	seems	seem	VBZ
cord-015021-pol2qm74	6176	3	more	more	RBR
cord-015021-pol2qm74	6176	4	important	important	JJ
cord-015021-pol2qm74	6176	5	to	to	TO
cord-015021-pol2qm74	6176	6	analyse	analyse	VB
cord-015021-pol2qm74	6176	7	and	and	CC
cord-015021-pol2qm74	6176	8	to	to	TO
cord-015021-pol2qm74	6176	9	criticize	criticize	VB
cord-015021-pol2qm74	6176	10	the	the	DT
cord-015021-pol2qm74	6176	11	design	design	NN
cord-015021-pol2qm74	6176	12	of	of	IN
cord-015021-pol2qm74	6176	13	tria	tria	NNP
cord-015021-pol2qm74	6176	14	/	/	SYM
cord-015021-pol2qm74	6176	15	s	s	NNP
cord-015021-pol2qm74	6176	16	before	before	IN
cord-015021-pol2qm74	6176	17	they	-PRON-	PRP
cord-015021-pol2qm74	6176	18	are	be	VBP
cord-015021-pol2qm74	6176	19	ongoing	ongoing	JJ
cord-015021-pol2qm74	6176	20	.	.	.
cord-015021-pol2qm74	6177	1	Incorporation	incorporation	NN
cord-015021-pol2qm74	6177	2	of	of	IN
cord-015021-pol2qm74	6177	3	that	that	DT
cord-015021-pol2qm74	6177	4	into	into	IN
cord-015021-pol2qm74	6177	5	development	development	NN
cord-015021-pol2qm74	6177	6	of	of	IN
cord-015021-pol2qm74	6177	7	a	a	DT
cord-015021-pol2qm74	6177	8	study	study	NN
cord-015021-pol2qm74	6177	9	protocol	protocol	NN
cord-015021-pol2qm74	6177	10	is	be	VBZ
cord-015021-pol2qm74	6177	11	the	the	DT
cord-015021-pol2qm74	6177	12	aim	aim	NN
cord-015021-pol2qm74	6177	13	of	of	IN
cord-015021-pol2qm74	6177	14	the	the	DT
cord-015021-pol2qm74	6177	15	following	follow	VBG
cord-015021-pol2qm74	6177	16	procedure	procedure	NN
cord-015021-pol2qm74	6177	17	:	:	:
cord-015021-pol2qm74	6177	18	The	the	DT
cord-015021-pol2qm74	6177	19	time	time	NN
cord-015021-pol2qm74	6177	20	-	-	HYPH
cord-015021-pol2qm74	6177	21	schedule	schedule	NN
cord-015021-pol2qm74	6177	22	of	of	IN
cord-015021-pol2qm74	6177	23	about	about	RB
cord-015021-pol2qm74	6177	24	two	two	CD
cord-015021-pol2qm74	6177	25	years	year	NNS
cord-015021-pol2qm74	6177	26	should	should	MD
cord-015021-pol2qm74	6177	27	include	include	VB
cord-015021-pol2qm74	6177	28	further	further	JJ
cord-015021-pol2qm74	6177	29	cell	cell	NN
cord-015021-pol2qm74	6177	30	culture	culture	NN
cord-015021-pol2qm74	6177	31	and	and	CC
cord-015021-pol2qm74	6177	32	animal	animal	NN
cord-015021-pol2qm74	6177	33	experiments	experiment	NNS
cord-015021-pol2qm74	6177	34	after	after	IN
cord-015021-pol2qm74	6177	35	the	the	DT
cord-015021-pol2qm74	6177	36	first	first	JJ
cord-015021-pol2qm74	6177	37	successful	successful	JJ
cord-015021-pol2qm74	6177	38	studies	study	NNS
cord-015021-pol2qm74	6177	39	showing	show	VBG
cord-015021-pol2qm74	6177	40	effectiveness	effectiveness	NN
cord-015021-pol2qm74	6177	41	.	.	.
cord-015021-pol2qm74	6178	1	Exhaustive	exhaustive	JJ
cord-015021-pol2qm74	6178	2	evidence	evidence	NN
cord-015021-pol2qm74	6178	3	for	for	IN
cord-015021-pol2qm74	6178	4	a	a	DT
cord-015021-pol2qm74	6178	5	dose	dose	NN
cord-015021-pol2qm74	6178	6	-	-	HYPH
cord-015021-pol2qm74	6178	7	dependent	dependent	JJ
cord-015021-pol2qm74	6178	8	cost	cost	NN
cord-015021-pol2qm74	6178	9	-	-	HYPH
cord-015021-pol2qm74	6178	10	banefit	banefit	NN
cord-015021-pol2qm74	6178	11	and	and	CC
cord-015021-pol2qm74	6178	12	near	near	IN
cord-015021-pol2qm74	6178	13	complete	complete	JJ
cord-015021-pol2qm74	6178	14	explanations	explanation	NNS
cord-015021-pol2qm74	6178	15	of	of	IN
cord-015021-pol2qm74	6178	16	the	the	DT
cord-015021-pol2qm74	6178	17	pathomechanism	pathomechanism	NN
cord-015021-pol2qm74	6178	18	should	should	MD
cord-015021-pol2qm74	6178	19	not	not	RB
cord-015021-pol2qm74	6178	20	be	be	VB
cord-015021-pol2qm74	6178	21	awaited	await	VBN
cord-015021-pol2qm74	6178	22	for	for	IN
cord-015021-pol2qm74	6178	23	development	development	NN
cord-015021-pol2qm74	6178	24	of	of	IN
cord-015021-pol2qm74	6178	25	the	the	DT
cord-015021-pol2qm74	6178	26	protocol	protocol	NN
cord-015021-pol2qm74	6178	27	of	of	IN
cord-015021-pol2qm74	6178	28	the	the	DT
cord-015021-pol2qm74	6178	29	clinical	clinical	JJ
cord-015021-pol2qm74	6178	30	study	study	NN
cord-015021-pol2qm74	6178	31	.	.	.
cord-015021-pol2qm74	6179	1	However	however	RB
cord-015021-pol2qm74	6179	2	,	,	,
cord-015021-pol2qm74	6179	3	a	a	DT
cord-015021-pol2qm74	6179	4	discussion	discussion	NN
cord-015021-pol2qm74	6179	5	forum	forum	NN
cord-015021-pol2qm74	6179	6	of	of	IN
cord-015021-pol2qm74	6179	7	experts	expert	NNS
cord-015021-pol2qm74	6179	8	should	should	MD
cord-015021-pol2qm74	6179	9	be	be	VB
cord-015021-pol2qm74	6179	10	performed	perform	VBN
cord-015021-pol2qm74	6179	11	in	in	IN
cord-015021-pol2qm74	6179	12	a	a	DT
cord-015021-pol2qm74	6179	13	recently	recently	RB
cord-015021-pol2qm74	6179	14	published	publish	VBN
cord-015021-pol2qm74	6179	15	,	,	,
cord-015021-pol2qm74	6179	16	almost	almost	RB
cord-015021-pol2qm74	6179	17	perfect	perfect	JJ
cord-015021-pol2qm74	6179	18	trial	trial	NN
cord-015021-pol2qm74	6179	19	in	in	IN
cord-015021-pol2qm74	6179	20	order	order	NN
cord-015021-pol2qm74	6179	21	to	to	TO
cord-015021-pol2qm74	6179	22	see	see	VB
cord-015021-pol2qm74	6179	23	the	the	DT
cord-015021-pol2qm74	6179	24	frontiers	frontier	NNS
cord-015021-pol2qm74	6179	25	of	of	IN
cord-015021-pol2qm74	6179	26	the	the	DT
cord-015021-pol2qm74	6179	27	present	present	JJ
cord-015021-pol2qm74	6179	28	research	research	NN
cord-015021-pol2qm74	6179	29	in	in	IN
cord-015021-pol2qm74	6179	30	cell	cell	NN
cord-015021-pol2qm74	6179	31	and	and	CC
cord-015021-pol2qm74	6179	32	molecular	molecular	JJ
cord-015021-pol2qm74	6179	33	biology	biology	NN
cord-015021-pol2qm74	6179	34	,	,	,
cord-015021-pol2qm74	6179	35	clinical	clinical	JJ
cord-015021-pol2qm74	6179	36	pharmacology	pharmacology	NN
cord-015021-pol2qm74	6179	37	,	,	,
cord-015021-pol2qm74	6179	38	statistics	statistic	NNS
cord-015021-pol2qm74	6179	39	and	and	CC
cord-015021-pol2qm74	6179	40	decision	decision	NN
cord-015021-pol2qm74	6179	41	making	making	NN
cord-015021-pol2qm74	6179	42	.	.	.
cord-015021-pol2qm74	6180	1	This	this	DT
cord-015021-pol2qm74	6180	2	should	should	MD
cord-015021-pol2qm74	6180	3	be	be	VB
cord-015021-pol2qm74	6180	4	followed	follow	VBN
cord-015021-pol2qm74	6180	5	by	by	IN
cord-015021-pol2qm74	6180	6	a	a	DT
cord-015021-pol2qm74	6180	7	metaanalysis	metaanalysis	NN
cord-015021-pol2qm74	6180	8	of	of	IN
cord-015021-pol2qm74	6180	9	at	at	RB
cord-015021-pol2qm74	6180	10	least	least	RBS
cord-015021-pol2qm74	6180	11	10	10	CD
cord-015021-pol2qm74	6180	12	study	study	NN
cord-015021-pol2qm74	6180	13	designs	design	NNS
cord-015021-pol2qm74	6180	14	on	on	IN
cord-015021-pol2qm74	6180	15	sepsis	sepsis	NN
cord-015021-pol2qm74	6180	16	with	with	IN
cord-015021-pol2qm74	6180	17	methods	method	NNS
cord-015021-pol2qm74	6180	18	of	of	IN
cord-015021-pol2qm74	6180	19	formalized	formalize	VBN
cord-015021-pol2qm74	6180	20	medical	medical	JJ
cord-015021-pol2qm74	6180	21	decision	decision	NN
cord-015021-pol2qm74	6180	22	making	make	VBG
cord-015021-pol2qm74	6180	23	(	(	-LRB-
cord-015021-pol2qm74	6180	24	decision	decision	NN
cord-015021-pol2qm74	6180	25	tree	tree	NN
cord-015021-pol2qm74	6180	26	)	)	-RRB-
cord-015021-pol2qm74	6180	27	.	.	.
cord-015021-pol2qm74	6181	1	Clinical	clinical	JJ
cord-015021-pol2qm74	6181	2	algorithms	algorithm	NNS
cord-015021-pol2qm74	6181	3	-developed	-develope	VBD
cord-015021-pol2qm74	6182	1	by	by	IN
cord-015021-pol2qm74	6182	2	objective	objective	JJ
cord-015021-pol2qm74	6182	3	methods	method	NNS
cord-015021-pol2qm74	6182	4	including	include	VBG
cord-015021-pol2qm74	6182	5	nominal	nominal	JJ
cord-015021-pol2qm74	6182	6	group	group	NN
cord-015021-pol2qm74	6182	7	processes	process	NNS
cord-015021-pol2qm74	6183	1	-should	-should	MD
cord-015021-pol2qm74	6183	2	be	be	VB
cord-015021-pol2qm74	6183	3	developed	develop	VBN
cord-015021-pol2qm74	6183	4	to	to	TO
cord-015021-pol2qm74	6183	5	standardize	standardize	VB
cord-015021-pol2qm74	6183	6	any	any	DT
cord-015021-pol2qm74	6183	7	concomitant	concomitant	JJ
cord-015021-pol2qm74	6183	8	treatment	treatment	NN
cord-015021-pol2qm74	6183	9	in	in	IN
cord-015021-pol2qm74	6183	10	the	the	DT
cord-015021-pol2qm74	6183	11	centers	center	NNS
cord-015021-pol2qm74	6183	12	considered	consider	VBN
cord-015021-pol2qm74	6183	13	for	for	IN
cord-015021-pol2qm74	6183	14	a	a	DT
cord-015021-pol2qm74	6183	15	multinentre	multinentre	NN
cord-015021-pol2qm74	6183	16	trial	trial	NN
cord-015021-pol2qm74	6183	17	.	.	.
cord-015021-pol2qm74	6184	1	The	the	DT
cord-015021-pol2qm74	6184	2	latter	latter	JJ
cord-015021-pol2qm74	6184	3	is	be	VBZ
cord-015021-pol2qm74	6184	4	usually	usually	RB
cord-015021-pol2qm74	6184	5	necessary	necessary	JJ
cord-015021-pol2qm74	6184	6	in	in	IN
cord-015021-pol2qm74	6184	7	the	the	DT
cord-015021-pol2qm74	6184	8	field	field	NN
cord-015021-pol2qm74	6184	9	of	of	IN
cord-015021-pol2qm74	6184	10	sepsis	sepsis	NN
cord-015021-pol2qm74	6184	11	.	.	.
cord-015021-pol2qm74	6185	1	Finally	finally	RB
cord-015021-pol2qm74	6185	2	,	,	,
cord-015021-pol2qm74	6185	3	a	a	DT
cord-015021-pol2qm74	6185	4	pilot	pilot	NN
cord-015021-pol2qm74	6185	5	study	study	NN
cord-015021-pol2qm74	6185	6	should	should	MD
cord-015021-pol2qm74	6185	7	be	be	VB
cord-015021-pol2qm74	6185	8	performed	perform	VBN
cord-015021-pol2qm74	6185	9	to	to	TO
cord-015021-pol2qm74	6185	10	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6185	11	not	not	RB
cord-015021-pol2qm74	6185	12	only	only	RB
cord-015021-pol2qm74	6185	13	feasability	feasability	NN
cord-015021-pol2qm74	6185	14	,	,	,
cord-015021-pol2qm74	6185	15	but	but	CC
cord-015021-pol2qm74	6185	16	to	to	TO
cord-015021-pol2qm74	6185	17	learn	learn	VB
cord-015021-pol2qm74	6185	18	about	about	IN
cord-015021-pol2qm74	6185	19	all	all	DT
cord-015021-pol2qm74	6185	20	possible	possible	JJ
cord-015021-pol2qm74	6185	21	types	type	NNS
cord-015021-pol2qm74	6185	22	of	of	IN
cord-015021-pol2qm74	6185	23	interventions	intervention	NNS
cord-015021-pol2qm74	6185	24	which	which	WDT
cord-015021-pol2qm74	6185	25	modify	modify	VBP
cord-015021-pol2qm74	6185	26	endpoints	endpoint	NNS
cord-015021-pol2qm74	6185	27	as	as	IN
cord-015021-pol2qm74	6185	28	response	response	NN
cord-015021-pol2qm74	6185	29	variables	variable	NNS
cord-015021-pol2qm74	6185	30	.	.	.
cord-015021-pol2qm74	6186	1	Especially	especially	RB
cord-015021-pol2qm74	6186	2	mortality	mortality	NN
cord-015021-pol2qm74	6186	3	is	be	VBZ
cord-015021-pol2qm74	6186	4	not	not	RB
cord-015021-pol2qm74	6186	5	free	free	JJ
cord-015021-pol2qm74	6186	6	from	from	IN
cord-015021-pol2qm74	6186	7	such	such	JJ
cord-015021-pol2qm74	6186	8	effects	effect	NNS
cord-015021-pol2qm74	6186	9	.	.	.
cord-015021-pol2qm74	6187	1	The	the	DT
cord-015021-pol2qm74	6187	2	time	time	NN
cord-015021-pol2qm74	6187	3	for	for	IN
cord-015021-pol2qm74	6187	4	the	the	DT
cord-015021-pol2qm74	6187	5	individual	individual	JJ
cord-015021-pol2qm74	6187	6	phases	phase	NNS
cord-015021-pol2qm74	6187	7	of	of	IN
cord-015021-pol2qm74	6187	8	this	this	DT
cord-015021-pol2qm74	6187	9	consensus	consensus	NN
cord-015021-pol2qm74	6187	10	-	-	HYPH
cord-015021-pol2qm74	6187	11	assisted	assist	VBN
cord-015021-pol2qm74	6187	12	process	process	NN
cord-015021-pol2qm74	6187	13	of	of	IN
cord-015021-pol2qm74	6187	14	protocol	protocol	NN
cord-015021-pol2qm74	6187	15	development	development	NN
cord-015021-pol2qm74	6187	16	have	have	VBP
cord-015021-pol2qm74	6187	17	to	to	TO
cord-015021-pol2qm74	6187	18	be	be	VB
cord-015021-pol2qm74	6187	19	shortened	shorten	VBN
cord-015021-pol2qm74	6187	20	by	by	IN
cord-015021-pol2qm74	6187	21	their	-PRON-	PRP$
cord-015021-pol2qm74	6187	22	temporal	temporal	JJ
cord-015021-pol2qm74	6187	23	hiterloeldug	hiterloeldug	NN
cord-015021-pol2qm74	6187	24	.	.	.
cord-015021-pol2qm74	6188	1	Due	due	IN
cord-015021-pol2qm74	6188	2	to	to	IN
cord-015021-pol2qm74	6188	3	the	the	DT
cord-015021-pol2qm74	6188	4	fast	fast	JJ
cord-015021-pol2qm74	6188	5	discovery	discovery	NN
cord-015021-pol2qm74	6188	6	of	of	IN
cord-015021-pol2qm74	6188	7	new	new	JJ
cord-015021-pol2qm74	6188	8	chemical	chemical	NN
cord-015021-pol2qm74	6188	9	factors	factor	NNS
cord-015021-pol2qm74	6188	10	in	in	IN
cord-015021-pol2qm74	6188	11	SIRS	SIRS	NNP
cord-015021-pol2qm74	6188	12	it	-PRON-	PRP
cord-015021-pol2qm74	6188	13	wilt	wilt	MD
cord-015021-pol2qm74	6188	14	otherwise	otherwise	RB
cord-015021-pol2qm74	6188	15	be	be	VB
cord-015021-pol2qm74	6188	16	impossible	impossible	JJ
cord-015021-pol2qm74	6188	17	to	to	TO
cord-015021-pol2qm74	6188	18	come	come	VB
cord-015021-pol2qm74	6188	19	up	up	RP
cord-015021-pol2qm74	6188	20	with	with	IN
cord-015021-pol2qm74	6188	21	results	result	NNS
cord-015021-pol2qm74	6188	22	of	of	IN
cord-015021-pol2qm74	6188	23	randomized	randomized	JJ
cord-015021-pol2qm74	6188	24	trials	trial	NNS
cord-015021-pol2qm74	6188	25	which	which	WDT
cord-015021-pol2qm74	6188	26	are	be	VBP
cord-015021-pol2qm74	6188	27	fascinating	fascinating	JJ
cord-015021-pol2qm74	6188	28	enough	enough	RB
cord-015021-pol2qm74	6188	29	to	to	TO
cord-015021-pol2qm74	6188	30	be	be	VB
cord-015021-pol2qm74	6188	31	incorporated	incorporate	VBN
cord-015021-pol2qm74	6188	32	in	in	IN
cord-015021-pol2qm74	6188	33	daily	daily	JJ
cord-015021-pol2qm74	6188	34	routine	routine	JJ
cord-015021-pol2qm74	6188	35	treatment	treatment	NN
cord-015021-pol2qm74	6188	36	.	.	.
cord-015021-pol2qm74	6189	1	Severity	severity	NN
cord-015021-pol2qm74	6189	2	scoring	scoring	NN
cord-015021-pol2qm74	6189	3	systems	system	NNS
cord-015021-pol2qm74	6189	4	are	be	VBP
cord-015021-pol2qm74	6189	5	intended	intend	VBN
cord-015021-pol2qm74	6189	6	to	to	TO
cord-015021-pol2qm74	6189	7	provide	provide	VB
cord-015021-pol2qm74	6189	8	a	a	DT
cord-015021-pol2qm74	6189	9	population	population	NN
cord-015021-pol2qm74	6189	10	-	-	HYPH
cord-015021-pol2qm74	6189	11	based	base	VBN
cord-015021-pol2qm74	6189	12	estimate	estimate	NN
cord-015021-pol2qm74	6189	13	for	for	IN
cord-015021-pol2qm74	6189	14	the	the	DT
cord-015021-pol2qm74	6189	15	risk	risk	NN
cord-015021-pol2qm74	6189	16	of	of	IN
cord-015021-pol2qm74	6189	17	an	an	DT
cord-015021-pol2qm74	6189	18	unwanted	unwanted	JJ
cord-015021-pol2qm74	6189	19	outcome	outcome	NN
cord-015021-pol2qm74	6189	20	resulting	result	VBG
cord-015021-pol2qm74	6189	21	from	from	IN
cord-015021-pol2qm74	6189	22	some	some	DT
cord-015021-pol2qm74	6189	23	disease	disease	NN
cord-015021-pol2qm74	6189	24	process	process	NN
cord-015021-pol2qm74	6189	25	.	.	.
cord-015021-pol2qm74	6190	1	In	in	IN
cord-015021-pol2qm74	6190	2	the	the	DT
cord-015021-pol2qm74	6190	3	area	area	NN
cord-015021-pol2qm74	6190	4	of	of	IN
cord-015021-pol2qm74	6190	5	infections	infection	NNS
cord-015021-pol2qm74	6190	6	and	and	CC
cord-015021-pol2qm74	6190	7	the	the	DT
cord-015021-pol2qm74	6190	8	"	"	``
cord-015021-pol2qm74	6190	9	septic	septic	JJ
cord-015021-pol2qm74	6190	10	"	"	''
cord-015021-pol2qm74	6190	11	response	response	NN
cord-015021-pol2qm74	6190	12	,	,	,
cord-015021-pol2qm74	6190	13	this	this	DT
cord-015021-pol2qm74	6190	14	has	have	VBZ
cord-015021-pol2qm74	6190	15	routinely	routinely	RB
cord-015021-pol2qm74	6190	16	been	be	VBN
cord-015021-pol2qm74	6190	17	defined	define	VBN
cord-015021-pol2qm74	6190	18	as	as	IN
cord-015021-pol2qm74	6190	19	death	death	NN
cord-015021-pol2qm74	6190	20	.	.	.
cord-015021-pol2qm74	6191	1	For	for	IN
cord-015021-pol2qm74	6191	2	anti	anti	JJ
cord-015021-pol2qm74	6191	3	-	-	JJ
cord-015021-pol2qm74	6191	4	infective	infective	JJ
cord-015021-pol2qm74	6191	5	trials	trial	NNS
cord-015021-pol2qm74	6191	6	,	,	,
cord-015021-pol2qm74	6191	7	there	there	EX
cord-015021-pol2qm74	6191	8	has	have	VBZ
cord-015021-pol2qm74	6191	9	been	be	VBN
cord-015021-pol2qm74	6191	10	a	a	DT
cord-015021-pol2qm74	6191	11	reasonable	reasonable	JJ
cord-015021-pol2qm74	6191	12	correlation	correlation	NN
cord-015021-pol2qm74	6191	13	of	of	IN
cord-015021-pol2qm74	6191	14	severity	severity	NN
cord-015021-pol2qm74	6191	15	(	(	-LRB-
cord-015021-pol2qm74	6191	16	APACHE	APACHE	NNP
cord-015021-pol2qm74	6191	17	ll	will	NNP
cord-015021-pol2qm74	6191	18	)	)	-RRB-
cord-015021-pol2qm74	6191	19	with	with	IN
cord-015021-pol2qm74	6191	20	outcome	outcome	NN
cord-015021-pol2qm74	6191	21	measured	measure	VBN
cord-015021-pol2qm74	6191	22	as	as	IN
cord-015021-pol2qm74	6191	23	persistent	persistent	JJ
cord-015021-pol2qm74	6191	24	or	or	CC
cord-015021-pol2qm74	6191	25	recurrent	recurrent	JJ
cord-015021-pol2qm74	6191	26	infection	infection	NN
cord-015021-pol2qm74	6191	27	,	,	,
cord-015021-pol2qm74	6191	28	but	but	CC
cord-015021-pol2qm74	6191	29	this	this	DT
cord-015021-pol2qm74	6191	30	is	be	VBZ
cord-015021-pol2qm74	6191	31	not	not	RB
cord-015021-pol2qm74	6191	32	as	as	RB
cord-015021-pol2qm74	6191	33	robust	robust	JJ
cord-015021-pol2qm74	6191	34	as	as	IN
cord-015021-pol2qm74	6191	35	the	the	DT
cord-015021-pol2qm74	6191	36	association	association	NN
cord-015021-pol2qm74	6191	37	with	with	IN
cord-015021-pol2qm74	6191	38	mortality	mortality	NN
cord-015021-pol2qm74	6191	39	.	.	.
cord-015021-pol2qm74	6192	1	It	-PRON-	PRP
cord-015021-pol2qm74	6192	2	is	be	VBZ
cord-015021-pol2qm74	6192	3	expected	expect	VBN
cord-015021-pol2qm74	6192	4	that	that	IN
cord-015021-pol2qm74	6192	5	non	non	JJ
cord-015021-pol2qm74	6192	6	-	-	JJ
cord-015021-pol2qm74	6192	7	lethal	lethal	JJ
cord-015021-pol2qm74	6192	8	failure	failure	NN
cord-015021-pol2qm74	6192	9	would	would	MD
cord-015021-pol2qm74	6192	10	not	not	RB
cord-015021-pol2qm74	6192	11	immediately	immediately	RB
cord-015021-pol2qm74	6192	12	correlate	correlate	VB
cord-015021-pol2qm74	6192	13	with	with	IN
cord-015021-pol2qm74	6192	14	disturbed	disturbed	JJ
cord-015021-pol2qm74	6192	15	physiology	physiology	NN
cord-015021-pol2qm74	6192	16	:	:	:
cord-015021-pol2qm74	6193	1	the	the	DT
cord-015021-pol2qm74	6193	2	basis	basis	NN
cord-015021-pol2qm74	6193	3	for	for	IN
cord-015021-pol2qm74	6193	4	antiinfective	antiinfective	JJ
cord-015021-pol2qm74	6193	5	failure	failure	NN
cord-015021-pol2qm74	6193	6	depends	depend	VBZ
cord-015021-pol2qm74	6193	7	on	on	IN
cord-015021-pol2qm74	6193	8	a	a	DT
cord-015021-pol2qm74	6193	9	variety	variety	NN
cord-015021-pol2qm74	6193	10	of	of	IN
cord-015021-pol2qm74	6193	11	factors	factor	NNS
cord-015021-pol2qm74	6193	12	not	not	RB
cord-015021-pol2qm74	6193	13	measured	measure	VBN
cord-015021-pol2qm74	6193	14	in	in	IN
cord-015021-pol2qm74	6193	15	severity	severity	NN
cord-015021-pol2qm74	6193	16	scoring	scoring	NN
cord-015021-pol2qm74	6193	17	,	,	,
cord-015021-pol2qm74	6193	18	such	such	JJ
cord-015021-pol2qm74	6193	19	as	as	IN
cord-015021-pol2qm74	6193	20	type	type	NN
cord-015021-pol2qm74	6193	21	of	of	IN
cord-015021-pol2qm74	6193	22	infecting	infect	VBG
cord-015021-pol2qm74	6193	23	organisms	organism	NNS
cord-015021-pol2qm74	6193	24	,	,	,
cord-015021-pol2qm74	6193	25	density	density	NN
cord-015021-pol2qm74	6193	26	and	and	CC
cord-015021-pol2qm74	6193	27	susceptibility	susceptibility	NN
cord-015021-pol2qm74	6193	28	to	to	IN
cord-015021-pol2qm74	6193	29	administered	administer	VBN
cord-015021-pol2qm74	6193	30	antimicrobia[s	antimicrobia[s	NNP
cord-015021-pol2qm74	6193	31	,	,	,
cord-015021-pol2qm74	6193	32	and	and	CC
cord-015021-pol2qm74	6193	33	anatomic	anatomic	JJ
cord-015021-pol2qm74	6193	34	features	feature	NNS
cord-015021-pol2qm74	6193	35	of	of	IN
cord-015021-pol2qm74	6193	36	infection	infection	NN
cord-015021-pol2qm74	6193	37	(	(	-LRB-
cord-015021-pol2qm74	6193	38	e.g.	e.g.	RB
cord-015021-pol2qm74	6193	39	,	,	,
cord-015021-pol2qm74	6193	40	pancreatic	pancreatic	NN
cord-015021-pol2qm74	6193	41	)	)	-RRB-
cord-015021-pol2qm74	6193	42	.	.	.
cord-015021-pol2qm74	6194	1	Severity	severity	NN
cord-015021-pol2qm74	6194	2	scoring	scoring	NN
cord-015021-pol2qm74	6194	3	is	be	VBZ
cord-015021-pol2qm74	6194	4	important	important	JJ
cord-015021-pol2qm74	6194	5	in	in	IN
cord-015021-pol2qm74	6194	6	differentiating	differentiate	VBG
cord-015021-pol2qm74	6194	7	these	these	DT
cord-015021-pol2qm74	6194	8	"	"	``
cord-015021-pol2qm74	6194	9	categorical	categorical	JJ
cord-015021-pol2qm74	6194	10	"	"	''
cord-015021-pol2qm74	6194	11	variables	variable	NNS
cord-015021-pol2qm74	6194	12	from	from	IN
cord-015021-pol2qm74	6194	13	continuous	continuous	JJ
cord-015021-pol2qm74	6194	14	(	(	-LRB-
cord-015021-pol2qm74	6194	15	physiologic	physiologic	JJ
cord-015021-pol2qm74	6194	16	)	)	-RRB-
cord-015021-pol2qm74	6194	17	variables	variable	NNS
cord-015021-pol2qm74	6194	18	.	.	.
cord-015021-pol2qm74	6195	1	There	there	EX
cord-015021-pol2qm74	6195	2	are	be	VBP
cord-015021-pol2qm74	6195	3	,	,	,
cord-015021-pol2qm74	6195	4	additionally	additionally	RB
cord-015021-pol2qm74	6195	5	,	,	,
cord-015021-pol2qm74	6195	6	a	a	DT
cord-015021-pol2qm74	6195	7	series	series	NN
cord-015021-pol2qm74	6195	8	of	of	IN
cord-015021-pol2qm74	6195	9	problems	problem	NNS
cord-015021-pol2qm74	6195	10	related	relate	VBN
cord-015021-pol2qm74	6195	11	to	to	IN
cord-015021-pol2qm74	6195	12	the	the	DT
cord-015021-pol2qm74	6195	13	cause	cause	NN
cord-015021-pol2qm74	6195	14	of	of	IN
cord-015021-pol2qm74	6195	15	death	death	NN
cord-015021-pol2qm74	6195	16	in	in	IN
cord-015021-pol2qm74	6195	17	relation	relation	NN
cord-015021-pol2qm74	6195	18	to	to	IN
cord-015021-pol2qm74	6195	19	severity	severity	NN
cord-015021-pol2qm74	6195	20	scoring	scoring	NN
cord-015021-pol2qm74	6195	21	.	.	.
cord-015021-pol2qm74	6196	1	In	in	IN
cord-015021-pol2qm74	6196	2	those	those	DT
cord-015021-pol2qm74	6196	3	tdals	tdal	NNS
cord-015021-pol2qm74	6196	4	in	in	IN
cord-015021-pol2qm74	6196	5	which	which	WDT
cord-015021-pol2qm74	6196	6	cause	cause	NN
cord-015021-pol2qm74	6196	7	of	of	IN
cord-015021-pol2qm74	6196	8	death	death	NN
cord-015021-pol2qm74	6196	9	is	be	VBZ
cord-015021-pol2qm74	6196	10	analyzed	analyze	VBN
cord-015021-pol2qm74	6196	11	,	,	,
cord-015021-pol2qm74	6196	12	high	high	JJ
cord-015021-pol2qm74	6196	13	severity	severity	NN
cord-015021-pol2qm74	6196	14	scores	score	NNS
cord-015021-pol2qm74	6196	15	did	do	VBD
cord-015021-pol2qm74	6196	16	not	not	RB
cord-015021-pol2qm74	6196	17	routinely	routinely	RB
cord-015021-pol2qm74	6196	18	predict	predict	VB
cord-015021-pol2qm74	6196	19	death	death	NN
cord-015021-pol2qm74	6196	20	as	as	IN
cord-015021-pol2qm74	6196	21	an	an	DT
cord-015021-pol2qm74	6196	22	immediate	immediate	JJ
cord-015021-pol2qm74	6196	23	sequelae	sequela	NNS
cord-015021-pol2qm74	6196	24	of	of	IN
cord-015021-pol2qm74	6196	25	sepsis	sepsis	NN
cord-015021-pol2qm74	6196	26	/	/	SYM
cord-015021-pol2qm74	6196	27	septic	septic	JJ
cord-015021-pol2qm74	6196	28	shock	shock	NN
cord-015021-pol2qm74	6196	29	.	.	.
cord-015021-pol2qm74	6197	1	Many	many	JJ
cord-015021-pol2qm74	6197	2	of	of	IN
cord-015021-pol2qm74	6197	3	the	the	DT
cord-015021-pol2qm74	6197	4	predicted	predict	VBN
cord-015021-pol2qm74	6197	5	deaths	death	NNS
cord-015021-pol2qm74	6197	6	occurred	occur	VBD
cord-015021-pol2qm74	6197	7	remotely	remotely	RB
cord-015021-pol2qm74	6197	8	of	of	IN
cord-015021-pol2qm74	6197	9	progressive	progressive	JJ
cord-015021-pol2qm74	6197	10	background	background	NN
cord-015021-pol2qm74	6197	11	diseases	disease	NNS
cord-015021-pol2qm74	6197	12	.	.	.
cord-015021-pol2qm74	6198	1	Other	other	JJ
cord-015021-pol2qm74	6198	2	important	important	JJ
cord-015021-pol2qm74	6198	3	problems	problem	NNS
cord-015021-pol2qm74	6198	4	with	with	IN
cord-015021-pol2qm74	6198	5	severity	severity	NN
cord-015021-pol2qm74	6198	6	scoring	scoring	NN
cord-015021-pol2qm74	6198	7	have	have	VBP
cord-015021-pol2qm74	6198	8	to	to	TO
cord-015021-pol2qm74	6198	9	do	do	VB
cord-015021-pol2qm74	6198	10	with	with	IN
cord-015021-pol2qm74	6198	11	lead	lead	JJ
cord-015021-pol2qm74	6198	12	-	-	HYPH
cord-015021-pol2qm74	6198	13	time	time	NN
cord-015021-pol2qm74	6198	14	bias	bias	NN
cord-015021-pol2qm74	6198	15	:	:	:
cord-015021-pol2qm74	6198	16	hew	hew	NNP
cord-015021-pol2qm74	6198	17	long	long	JJ
cord-015021-pol2qm74	6198	18	patients	patient	NNS
cord-015021-pol2qm74	6198	19	were	be	VBD
cord-015021-pol2qm74	6198	20	ill	ill	JJ
cord-015021-pol2qm74	6198	21	before	before	IN
cord-015021-pol2qm74	6198	22	entry	entry	NN
cord-015021-pol2qm74	6198	23	into	into	IN
cord-015021-pol2qm74	6198	24	the	the	DT
cord-015021-pol2qm74	6198	25	study	study	NN
cord-015021-pol2qm74	6198	26	.	.	.
cord-015021-pol2qm74	6199	1	Statistical	statistical	JJ
cord-015021-pol2qm74	6199	2	techniques	technique	NNS
cord-015021-pol2qm74	6199	3	for	for	IN
cord-015021-pol2qm74	6199	4	condensing	condense	VBG
cord-015021-pol2qm74	6199	5	various	various	JJ
cord-015021-pol2qm74	6199	6	categorical	categorical	JJ
cord-015021-pol2qm74	6199	7	and	and	CC
cord-015021-pol2qm74	6199	8	continuous	continuous	JJ
cord-015021-pol2qm74	6199	9	variables	variable	NNS
cord-015021-pol2qm74	6199	10	,	,	,
cord-015021-pol2qm74	6199	11	as	as	RB
cord-015021-pol2qm74	6199	12	well	well	RB
cord-015021-pol2qm74	6199	13	as	as	IN
cord-015021-pol2qm74	6199	14	factoring	factor	VBG
cord-015021-pol2qm74	6199	15	in	in	IN
cord-015021-pol2qm74	6199	16	information	information	NN
cord-015021-pol2qm74	6199	17	requiring	require	VBG
cord-015021-pol2qm74	6199	18	the	the	DT
cord-015021-pol2qm74	6199	19	pharmacodynamics	pharmacodynamic	NNS
cord-015021-pol2qm74	6199	20	of	of	IN
cord-015021-pol2qm74	6199	21	agents	agent	NNS
cord-015021-pol2qm74	6199	22	which	which	WDT
cord-015021-pol2qm74	6199	23	affect	affect	VBP
cord-015021-pol2qm74	6199	24	outcome	outcome	NN
cord-015021-pol2qm74	6199	25	,	,	,
cord-015021-pol2qm74	6199	26	are	be	VBP
cord-015021-pol2qm74	6199	27	being	be	VBG
cord-015021-pol2qm74	6199	28	developed	develop	VBN
cord-015021-pol2qm74	6199	29	to	to	TO
cord-015021-pol2qm74	6199	30	further	further	RB
cord-015021-pol2qm74	6199	31	refine	refine	VB
cord-015021-pol2qm74	6199	32	deviation	deviation	NN
cord-015021-pol2qm74	6199	33	from	from	IN
cord-015021-pol2qm74	6199	34	predictive	predictive	JJ
cord-015021-pol2qm74	6199	35	equations	equation	NNS
cord-015021-pol2qm74	6199	36	as	as	IN
cord-015021-pol2qm74	6199	37	an	an	DT
cord-015021-pol2qm74	6199	38	outcome	outcome	NN
cord-015021-pol2qm74	6199	39	measure	measure	NN
cord-015021-pol2qm74	6199	40	.	.	.
cord-015021-pol2qm74	6200	1	Stepwise	Stepwise	NNP
cord-015021-pol2qm74	6200	2	logistic	logistic	JJ
cord-015021-pol2qm74	6200	3	regression	regression	NN
cord-015021-pol2qm74	6200	4	analysis	analysis	NN
cord-015021-pol2qm74	6200	5	has	have	VBZ
cord-015021-pol2qm74	6200	6	identified	identify	VBN
cord-015021-pol2qm74	6200	7	the	the	DT
cord-015021-pol2qm74	6200	8	presence	presence	NN
cord-015021-pol2qm74	6200	9	of	of	IN
cord-015021-pol2qm74	6200	10	shock	shock	NN
cord-015021-pol2qm74	6200	11	,	,	,
cord-015021-pol2qm74	6200	12	intm	intm	NN
cord-015021-pol2qm74	6200	13	-	-	HYPH
cord-015021-pol2qm74	6200	14	abdominal	abdominal	JJ
cord-015021-pol2qm74	6200	15	or	or	CC
cord-015021-pol2qm74	6200	16	unknown	unknown	JJ
cord-015021-pol2qm74	6200	17	source	source	NN
cord-015021-pol2qm74	6200	18	of	of	IN
cord-015021-pol2qm74	6200	19	infection	infection	NN
cord-015021-pol2qm74	6200	20	,	,	,
cord-015021-pol2qm74	6200	21	hospital	hospital	NN
cord-015021-pol2qm74	6200	22	acquired	acquire	VBN
cord-015021-pol2qm74	6200	23	infection	infection	NN
cord-015021-pol2qm74	6200	24	,	,	,
cord-015021-pol2qm74	6200	25	age	age	NN
cord-015021-pol2qm74	6200	26	greater	great	JJR
cord-015021-pol2qm74	6200	27	than	than	IN
cord-015021-pol2qm74	6200	28	70	70	CD
cord-015021-pol2qm74	6200	29	years	year	NNS
cord-015021-pol2qm74	6200	30	,	,	,
cord-015021-pol2qm74	6200	31	neutropenia	neutropenia	NN
cord-015021-pol2qm74	6200	32	and	and	CC
cord-015021-pol2qm74	6200	33	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6200	34	antimicmbial	antimicmbial	JJ
cord-015021-pol2qm74	6200	35	therapy	therapy	NN
cord-015021-pol2qm74	6200	36	as	as	IN
cord-015021-pol2qm74	6200	37	independent	independent	JJ
cord-015021-pol2qm74	6200	38	variables	variable	NNS
cord-015021-pol2qm74	6200	39	associated	associate	VBN
cord-015021-pol2qm74	6200	40	with	with	IN
cord-015021-pol2qm74	6200	41	increased	increase	VBN
cord-015021-pol2qm74	6200	42	mortality	mortality	NN
cord-015021-pol2qm74	6200	43	in	in	IN
cord-015021-pol2qm74	6200	44	sepsis	sepsis	NN
cord-015021-pol2qm74	6200	45	.	.	.
cord-015021-pol2qm74	6201	1	Maldistribution	maldistribution	NN
cord-015021-pol2qm74	6201	2	or	or	CC
cord-015021-pol2qm74	6201	3	"	"	``
cord-015021-pol2qm74	6201	4	these	these	DT
cord-015021-pol2qm74	6201	5	variables	variable	NNS
cord-015021-pol2qm74	6201	6	is	be	VBZ
cord-015021-pol2qm74	6201	7	a	a	DT
cord-015021-pol2qm74	6201	8	concern	concern	NN
cord-015021-pol2qm74	6201	9	in	in	IN
cord-015021-pol2qm74	6201	10	targe	targe	NN
cord-015021-pol2qm74	6201	11	randomized	randomized	JJ
cord-015021-pol2qm74	6201	12	clinical	clinical	JJ
cord-015021-pol2qm74	6201	13	studies	study	NNS
cord-015021-pol2qm74	6201	14	.	.	.
cord-015021-pol2qm74	6202	1	It	-PRON-	PRP
cord-015021-pol2qm74	6202	2	should	should	MD
cord-015021-pol2qm74	6202	3	be	be	VB
cord-015021-pol2qm74	6202	4	noted	note	VBN
cord-015021-pol2qm74	6202	5	that	that	IN
cord-015021-pol2qm74	6202	6	only	only	RB
cord-015021-pol2qm74	6202	7	the	the	DT
cord-015021-pol2qm74	6202	8	selection	selection	NN
cord-015021-pol2qm74	6202	9	of	of	IN
cord-015021-pol2qm74	6202	10	antimicrobiaI	antimicrobiaI	NNP
cord-015021-pol2qm74	6202	11	therapy	therapy	NN
cord-015021-pol2qm74	6202	12	could	could	MD
cord-015021-pol2qm74	6202	13	be	be	VB
cord-015021-pol2qm74	6202	14	addre.~'sed	addre.~'se	VBN
cord-015021-pol2qm74	6202	15	and	and	CC
cord-015021-pol2qm74	6202	16	altered	alter	VBN
cord-015021-pol2qm74	6202	17	at	at	IN
cord-015021-pol2qm74	6202	18	the	the	DT
cord-015021-pol2qm74	6202	19	time	time	NN
cord-015021-pol2qm74	6202	20	of	of	IN
cord-015021-pol2qm74	6202	21	enrollment	enrollment	NN
cord-015021-pol2qm74	6202	22	in	in	IN
cord-015021-pol2qm74	6202	23	a	a	DT
cord-015021-pol2qm74	6202	24	sepsis	sepsis	NN
cord-015021-pol2qm74	6202	25	clinics	clinic	NNS
cord-015021-pol2qm74	6202	26	]	]	-RRB-
cord-015021-pol2qm74	6202	27	trial	trial	NN
cord-015021-pol2qm74	6202	28	.	.	.
cord-015021-pol2qm74	6203	1	Inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6203	2	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	6203	3	therapy	therapy	NN
cord-015021-pol2qm74	6203	4	has	have	VBZ
cord-015021-pol2qm74	6203	5	been	be	VBN
cord-015021-pol2qm74	6203	6	noted	note	VBN
cord-015021-pol2qm74	6203	7	in	in	IN
cord-015021-pol2qm74	6203	8	41%-66	41%-66	CD
cord-015021-pol2qm74	6203	9	%	%	NN
cord-015021-pol2qm74	6203	10	of	of	IN
cord-015021-pol2qm74	6203	11	septic	septic	JJ
cord-015021-pol2qm74	6203	12	patients	patient	NNS
cord-015021-pol2qm74	6203	13	.	.	.
cord-015021-pol2qm74	6204	1	Well	well	UH
cord-015021-pol2qm74	6204	2	designed	design	VBN
cord-015021-pol2qm74	6204	3	,	,	,
cord-015021-pol2qm74	6204	4	randomized	randomized	JJ
cord-015021-pol2qm74	6204	5	sepsis	sepsis	NN
cord-015021-pol2qm74	6204	6	trials	trial	NNS
cord-015021-pol2qm74	6204	7	do	do	VBP
cord-015021-pol2qm74	6204	8	not	not	RB
cord-015021-pol2qm74	6204	9	assure	assure	VB
cord-015021-pol2qm74	6204	10	the	the	DT
cord-015021-pol2qm74	6204	11	absence	absence	NN
cord-015021-pol2qm74	6204	12	of	of	IN
cord-015021-pol2qm74	6204	13	imbalance	imbalance	NN
cord-015021-pol2qm74	6204	14	between	between	IN
cord-015021-pol2qm74	6204	15	treatment	treatment	NN
cord-015021-pol2qm74	6204	16	and	and	CC
cord-015021-pol2qm74	6204	17	control	control	NN
cord-015021-pol2qm74	6204	18	groups	group	NNS
cord-015021-pol2qm74	6204	19	with	with	IN
cord-015021-pol2qm74	6204	20	regard	regard	NN
cord-015021-pol2qm74	6204	21	to	to	IN
cord-015021-pol2qm74	6204	22	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6204	23	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6204	24	therapy	therapy	NN
cord-015021-pol2qm74	6204	25	,	,	,
cord-015021-pol2qm74	6204	26	especially	especially	RB
cord-015021-pol2qm74	6204	27	with	with	IN
cord-015021-pol2qm74	6204	28	subgroup	subgroup	NN
cord-015021-pol2qm74	6204	29	analysis	analysis	NN
cord-015021-pol2qm74	6204	30	.	.	.
cord-015021-pol2qm74	6205	1	Statistical	statistical	JJ
cord-015021-pol2qm74	6205	2	manipulation	manipulation	NN
cord-015021-pol2qm74	6205	3	to	to	TO
cord-015021-pol2qm74	6205	4	correct	correct	VB
cord-015021-pol2qm74	6205	5	for	for	IN
cord-015021-pol2qm74	6205	6	any	any	DT
cord-015021-pol2qm74	6205	7	imbalance	imbalance	NN
cord-015021-pol2qm74	6205	8	is	be	VBZ
cord-015021-pol2qm74	6205	9	appropriate	appropriate	JJ
cord-015021-pol2qm74	6205	10	but	but	CC
cord-015021-pol2qm74	6205	11	avoiding	avoid	VBG
cord-015021-pol2qm74	6205	12	imbalance	imbalance	NN
cord-015021-pol2qm74	6205	13	is	be	VBZ
cord-015021-pol2qm74	6205	14	ideal	ideal	JJ
cord-015021-pol2qm74	6205	15	.	.	.
cord-015021-pol2qm74	6206	1	Selection	selection	NN
cord-015021-pol2qm74	6206	2	of	of	IN
cord-015021-pol2qm74	6206	3	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6206	4	in	in	IN
cord-015021-pol2qm74	6206	5	septic	septic	JJ
cord-015021-pol2qm74	6206	6	patients	patient	NNS
cord-015021-pol2qm74	6206	7	requires	require	VBZ
cord-015021-pol2qm74	6206	8	such	such	JJ
cord-015021-pol2qm74	6206	9	considerations	consideration	NNS
cord-015021-pol2qm74	6206	10	as	as	IN
cord-015021-pol2qm74	6206	11	clinical	clinical	JJ
cord-015021-pol2qm74	6206	12	setting	setting	NN
cord-015021-pol2qm74	6206	13	(	(	-LRB-
cord-015021-pol2qm74	6206	14	history	history	NN
cord-015021-pol2qm74	6206	15	,	,	,
cord-015021-pol2qm74	6206	16	physical	physical	JJ
cord-015021-pol2qm74	6206	17	examination	examination	NN
cord-015021-pol2qm74	6206	18	and	and	CC
cord-015021-pol2qm74	6206	19	underlying	underlying	JJ
cord-015021-pol2qm74	6206	20	disease	disease	NN
cord-015021-pol2qm74	6206	21	)	)	-RRB-
cord-015021-pol2qm74	6206	22	,	,	,
cord-015021-pol2qm74	6206	23	appropriate	appropriate	JJ
cord-015021-pol2qm74	6206	24	laboratory	laboratory	NN
cord-015021-pol2qm74	6206	25	tests	test	NNS
cord-015021-pol2qm74	6206	26	(	(	-LRB-
cord-015021-pol2qm74	6206	27	such	such	JJ
cord-015021-pol2qm74	6206	28	as	as	IN
cord-015021-pol2qm74	6206	29	gram	gram	NN
cord-015021-pol2qm74	6206	30	stain	stain	NN
cord-015021-pol2qm74	6206	31	)	)	-RRB-
cord-015021-pol2qm74	6206	32	,	,	,
cord-015021-pol2qm74	6206	33	identification	identification	NN
cord-015021-pol2qm74	6206	34	of	of	IN
cord-015021-pol2qm74	6206	35	source	source	NN
cord-015021-pol2qm74	6206	36	and	and	CC
cord-015021-pol2qm74	6206	37	associated	associated	JJ
cord-015021-pol2qm74	6206	38	bacterial	bacterial	JJ
cord-015021-pol2qm74	6206	39	flora	flora	NNS
cord-015021-pol2qm74	6206	40	,	,	,
cord-015021-pol2qm74	6206	41	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6206	42	susceptibility	susceptibility	NN
cord-015021-pol2qm74	6206	43	patterns	pattern	NNS
cord-015021-pol2qm74	6206	44	for	for	IN
cord-015021-pol2qm74	6206	45	that	that	DT
cord-015021-pol2qm74	6206	46	hospital	hospital	NN
cord-015021-pol2qm74	6206	47	and	and	CC
cord-015021-pol2qm74	6206	48	likelihood	likelihood	NN
cord-015021-pol2qm74	6206	49	of	of	IN
cord-015021-pol2qm74	6206	50	resistant	resistant	JJ
cord-015021-pol2qm74	6206	51	organisms	organism	NNS
cord-015021-pol2qm74	6206	52	.	.	.
cord-015021-pol2qm74	6207	1	Determination	determination	NN
cord-015021-pol2qm74	6207	2	of	of	IN
cord-015021-pol2qm74	6207	3	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6207	4	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6207	5	therapy	therapy	NN
cord-015021-pol2qm74	6207	6	is	be	VBZ
cord-015021-pol2qm74	6207	7	made	make	VBN
cord-015021-pol2qm74	6207	8	retrospectively	retrospectively	RB
cord-015021-pol2qm74	6207	9	after	after	IN
cord-015021-pol2qm74	6207	10	culture	culture	NN
cord-015021-pol2qm74	6207	11	results	result	NNS
cord-015021-pol2qm74	6207	12	are	be	VBP
cord-015021-pol2qm74	6207	13	available	available	JJ
cord-015021-pol2qm74	6207	14	.	.	.
cord-015021-pol2qm74	6208	1	In	in	IN
cord-015021-pol2qm74	6208	2	some	some	DT
cord-015021-pol2qm74	6208	3	circunmtances	circunmtance	NNS
cord-015021-pol2qm74	6208	4	the	the	DT
cord-015021-pol2qm74	6208	5	organism	organism	NN
cord-015021-pol2qm74	6208	6	and	and	CC
cord-015021-pol2qm74	6208	7	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6208	8	sensitivities	sensitivity	NNS
cord-015021-pol2qm74	6208	9	can	can	MD
cord-015021-pol2qm74	6208	10	not	not	RB
cord-015021-pol2qm74	6208	11	be	be	VB
cord-015021-pol2qm74	6208	12	predicted	predict	VBN
cord-015021-pol2qm74	6208	13	,	,	,
cord-015021-pol2qm74	6208	14	while	while	IN
cord-015021-pol2qm74	6208	15	in	in	IN
cord-015021-pol2qm74	6208	16	others	other	NNS
cord-015021-pol2qm74	6208	17	it	-PRON-	PRP
cord-015021-pol2qm74	6208	18	can	can	MD
cord-015021-pol2qm74	6208	19	.	.	.
cord-015021-pol2qm74	6209	1	Leibovici	Leibovici	NNP
cord-015021-pol2qm74	6209	2	et	et	IN
cord-015021-pol2qm74	6209	3	al	al	NNP
cord-015021-pol2qm74	6209	4	identified	identify	VBD
cord-015021-pol2qm74	6209	5	hospital	hospital	NN
cord-015021-pol2qm74	6209	6	acquired	acquire	VBD
cord-015021-pol2qm74	6209	7	infection	infection	NN
cord-015021-pol2qm74	6209	8	,	,	,
cord-015021-pol2qm74	6209	9	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6209	10	treatment	treatment	NN
cord-015021-pol2qm74	6209	11	before	before	IN
cord-015021-pol2qm74	6209	12	a	a	DT
cord-015021-pol2qm74	6209	13	bacteremic	bacteremic	JJ
cord-015021-pol2qm74	6209	14	episode	episode	NN
cord-015021-pol2qm74	6209	15	,	,	,
cord-015021-pol2qm74	6209	16	endotracheal	endotracheal	NN
cord-015021-pol2qm74	6209	17	intubetion	intubetion	NN
cord-015021-pol2qm74	6209	18	and	and	CC
cord-015021-pol2qm74	6209	19	thermal	thermal	JJ
cord-015021-pol2qm74	6209	20	trauma	trauma	NN
cord-015021-pol2qm74	6209	21	as	as	IN
cord-015021-pol2qm74	6209	22	independent	independent	JJ
cord-015021-pol2qm74	6209	23	variables	variable	NNS
cord-015021-pol2qm74	6209	24	which	which	WDT
cord-015021-pol2qm74	6209	25	predicted	predict	VBD
cord-015021-pol2qm74	6209	26	isolation	isolation	NN
cord-015021-pol2qm74	6209	27	of	of	IN
cord-015021-pol2qm74	6209	28	a	a	DT
cord-015021-pol2qm74	6209	29	multiresistant	multiresistant	JJ
cord-015021-pol2qm74	6209	30	organism	organism	NN
cord-015021-pol2qm74	6209	31	.	.	.
cord-015021-pol2qm74	6210	1	The	the	DT
cord-015021-pol2qm74	6210	2	same	same	JJ
cord-015021-pol2qm74	6210	3	authors	author	NNS
cord-015021-pol2qm74	6210	4	developed	develop	VBD
cord-015021-pol2qm74	6210	5	a	a	DT
cord-015021-pol2qm74	6210	6	predictive	predictive	JJ
cord-015021-pol2qm74	6210	7	index	index	NN
cord-015021-pol2qm74	6210	8	for	for	IN
cord-015021-pol2qm74	6210	9	resistant	resistant	JJ
cord-015021-pol2qm74	6210	10	organisms	organism	NNS
cord-015021-pol2qm74	6210	11	,	,	,
cord-015021-pol2qm74	6210	12	which	which	WDT
cord-015021-pol2qm74	6210	13	when	when	WRB
cord-015021-pol2qm74	6210	14	compared	compare	VBN
cord-015021-pol2qm74	6210	15	to	to	IN
cord-015021-pol2qm74	6210	16	prescriptions	prescription	NNS
cord-015021-pol2qm74	6210	17	of	of	IN
cord-015021-pol2qm74	6210	18	attending	attend	VBG
cord-015021-pol2qm74	6210	19	physicians	physician	NNS
cord-015021-pol2qm74	6210	20	,	,	,
cord-015021-pol2qm74	6210	21	improved	improve	VBD
cord-015021-pol2qm74	6210	22	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6210	23	selection	selection	NN
cord-015021-pol2qm74	6210	24	in	in	IN
cord-015021-pol2qm74	6210	25	critically	critically	RB
cord-015021-pol2qm74	6210	26	ill	ill	JJ
cord-015021-pol2qm74	6210	27	patients	patient	NNS
cord-015021-pol2qm74	6210	28	.	.	.
cord-015021-pol2qm74	6211	1	Including	include	VBG
cord-015021-pol2qm74	6211	2	a	a	DT
cord-015021-pol2qm74	6211	3	standard	standard	JJ
cord-015021-pol2qm74	6211	4	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6211	5	regimen	regimen	NN
cord-015021-pol2qm74	6211	6	for	for	IN
cord-015021-pol2qm74	6211	7	all	all	DT
cord-015021-pol2qm74	6211	8	septic	septic	JJ
cord-015021-pol2qm74	6211	9	patients	patient	NNS
cord-015021-pol2qm74	6211	10	in	in	IN
cord-015021-pol2qm74	6211	11	a	a	DT
cord-015021-pol2qm74	6211	12	clinical	clinical	JJ
cord-015021-pol2qm74	6211	13	trial	trial	NN
cord-015021-pol2qm74	6211	14	is	be	VBZ
cord-015021-pol2qm74	6211	15	impractical	impractical	JJ
cord-015021-pol2qm74	6211	16	.	.	.
cord-015021-pol2qm74	6212	1	There	there	EX
cord-015021-pol2qm74	6212	2	is	be	VBZ
cord-015021-pol2qm74	6212	3	too	too	RB
cord-015021-pol2qm74	6212	4	much	much	JJ
cord-015021-pol2qm74	6212	5	interhopsital	interhopsital	JJ
cord-015021-pol2qm74	6212	6	variability	variability	NN
cord-015021-pol2qm74	6212	7	in	in	IN
cord-015021-pol2qm74	6212	8	flora	flora	NNS
cord-015021-pol2qm74	6212	9	and	and	CC
cord-015021-pol2qm74	6212	10	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6212	11	susceptibility	susceptibility	NN
cord-015021-pol2qm74	6212	12	.	.	.
cord-015021-pol2qm74	6213	1	In	in	IN
cord-015021-pol2qm74	6213	2	addition	addition	NN
cord-015021-pol2qm74	6213	3	,	,	,
cord-015021-pol2qm74	6213	4	the	the	DT
cord-015021-pol2qm74	6213	5	aggressive	aggressive	JJ
cord-015021-pol2qm74	6213	6	broad	broad	JJ
cord-015021-pol2qm74	6213	7	spectrum	spectrum	NN
cord-015021-pol2qm74	6213	8	coverage	coverage	NN
cord-015021-pol2qm74	6213	9	necessary	necessary	JJ
cord-015021-pol2qm74	6213	10	for	for	IN
cord-015021-pol2qm74	6213	11	some	some	DT
cord-015021-pol2qm74	6213	12	patients	patient	NNS
cord-015021-pol2qm74	6213	13	is	be	VBZ
cord-015021-pol2qm74	6213	14	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6213	15	for	for	IN
cord-015021-pol2qm74	6213	16	others	other	NNS
cord-015021-pol2qm74	6213	17	.	.	.
cord-015021-pol2qm74	6214	1	A	a	DT
cord-015021-pol2qm74	6214	2	protocol	protocol	NN
cord-015021-pol2qm74	6214	3	which	which	WDT
cord-015021-pol2qm74	6214	4	guides	guide	VBZ
cord-015021-pol2qm74	6214	5	a	a	DT
cord-015021-pol2qm74	6214	6	prescribing	prescribe	VBG
cord-015021-pol2qm74	6214	7	physician	physician	NN
cord-015021-pol2qm74	6214	8	through	through	IN
cord-015021-pol2qm74	6214	9	a	a	DT
cord-015021-pol2qm74	6214	10	logical	logical	JJ
cord-015021-pol2qm74	6214	11	chain	chain	NN
cord-015021-pol2qm74	6214	12	of	of	IN
cord-015021-pol2qm74	6214	13	reasoning	reasoning	NN
cord-015021-pol2qm74	6214	14	might	may	MD
cord-015021-pol2qm74	6214	15	improve	improve	VB
cord-015021-pol2qm74	6214	16	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6214	17	selection	selection	NN
cord-015021-pol2qm74	6214	18	in	in	IN
cord-015021-pol2qm74	6214	19	critically	critically	RB
cord-015021-pol2qm74	6214	20	ill	ill	JJ
cord-015021-pol2qm74	6214	21	patients	patient	NNS
cord-015021-pol2qm74	6214	22	and	and	CC
cord-015021-pol2qm74	6214	23	could	could	MD
cord-015021-pol2qm74	6214	24	be	be	VB
cord-015021-pol2qm74	6214	25	included	include	VBN
cord-015021-pol2qm74	6214	26	in	in	IN
cord-015021-pol2qm74	6214	27	the	the	DT
cord-015021-pol2qm74	6214	28	design	design	NN
cord-015021-pol2qm74	6214	29	of	of	IN
cord-015021-pol2qm74	6214	30	a	a	DT
cord-015021-pol2qm74	6214	31	clinical	clinical	JJ
cord-015021-pol2qm74	6214	32	trial	trial	NN
cord-015021-pol2qm74	6214	33	in	in	IN
cord-015021-pol2qm74	6214	34	sepsis	sepsis	NN
cord-015021-pol2qm74	6214	35	.	.	.
cord-015021-pol2qm74	6215	1	Although	although	IN
cord-015021-pol2qm74	6215	2	this	this	DT
cord-015021-pol2qm74	6215	3	approach	approach	NN
cord-015021-pol2qm74	6215	4	might	may	MD
cord-015021-pol2qm74	6215	5	minimize	minimize	VB
cord-015021-pol2qm74	6215	6	potential	potential	NN
cord-015021-pol2qm74	6215	7	for	for	IN
cord-015021-pol2qm74	6215	8	maldistribution	maldistribution	NN
cord-015021-pol2qm74	6215	9	of	of	IN
cord-015021-pol2qm74	6215	10	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6215	11	antimierobial	antimierobial	JJ
cord-015021-pol2qm74	6215	12	therapy	therapy	NN
cord-015021-pol2qm74	6215	13	,	,	,
cord-015021-pol2qm74	6215	14	it	-PRON-	PRP
cord-015021-pol2qm74	6215	15	would	would	MD
cord-015021-pol2qm74	6215	16	likely	likely	RB
cord-015021-pol2qm74	6215	17	create	create	VB
cord-015021-pol2qm74	6215	18	multiple	multiple	JJ
cord-015021-pol2qm74	6215	19	problem	problem	NN
cord-015021-pol2qm74	6215	20	areas	area	NNS
cord-015021-pol2qm74	6215	21	.	.	.
cord-015021-pol2qm74	6216	1	Will	Will	MD
cord-015021-pol2qm74	6216	2	the	the	DT
cord-015021-pol2qm74	6216	3	patient	patient	NN
cord-015021-pol2qm74	6216	4	's	's	POS
cord-015021-pol2qm74	6216	5	physicians	physician	NNS
cord-015021-pol2qm74	6216	6	agree	agree	VBP
cord-015021-pol2qm74	6216	7	to	to	IN
cord-015021-pol2qm74	6216	8	the	the	DT
cord-015021-pol2qm74	6216	9	protocol	protocol	NN
cord-015021-pol2qm74	6216	10	choice	choice	NN
cord-015021-pol2qm74	6216	11	?	?	.
cord-015021-pol2qm74	6217	1	What	what	WP
cord-015021-pol2qm74	6217	2	is	be	VBZ
cord-015021-pol2qm74	6217	3	the	the	DT
cord-015021-pol2qm74	6217	4	availability	availability	NN
cord-015021-pol2qm74	6217	5	of	of	IN
cord-015021-pol2qm74	6217	6	speciftc	speciftc	NNP
cord-015021-pol2qm74	6217	7	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6217	8	at	at	IN
cord-015021-pol2qm74	6217	9	a	a	DT
cord-015021-pol2qm74	6217	10	participating	participate	VBG
cord-015021-pol2qm74	6217	11	hospital	hospital	NN
cord-015021-pol2qm74	6217	12	?	?	.
cord-015021-pol2qm74	6218	1	What	what	WP
cord-015021-pol2qm74	6218	2	is	be	VBZ
cord-015021-pol2qm74	6218	3	the	the	DT
cord-015021-pol2qm74	6218	4	aplpiieability	aplpiieability	NN
cord-015021-pol2qm74	6218	5	of	of	IN
cord-015021-pol2qm74	6218	6	study	study	NN
cord-015021-pol2qm74	6218	7	results	result	NNS
cord-015021-pol2qm74	6218	8	in	in	IN
cord-015021-pol2qm74	6218	9	typical	typical	JJ
cord-015021-pol2qm74	6218	10	clinical	clinical	JJ
cord-015021-pol2qm74	6218	11	situations	situation	NNS
cord-015021-pol2qm74	6218	12	?	?	.
cord-015021-pol2qm74	6219	1	If	if	IN
cord-015021-pol2qm74	6219	2	there	there	EX
cord-015021-pol2qm74	6219	3	is	be	VBZ
cord-015021-pol2qm74	6219	4	agreement	agreement	NN
cord-015021-pol2qm74	6219	5	that	that	IN
cord-015021-pol2qm74	6219	6	thin	thin	JJ
cord-015021-pol2qm74	6219	7	is	be	VBZ
cord-015021-pol2qm74	6219	8	an	an	DT
cord-015021-pol2qm74	6219	9	appropriate	appropriate	JJ
cord-015021-pol2qm74	6219	10	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6219	11	protocol	protocol	NN
cord-015021-pol2qm74	6219	12	,	,	,
cord-015021-pol2qm74	6219	13	should	should	MD
cord-015021-pol2qm74	6219	14	it	-PRON-	PRP
cord-015021-pol2qm74	6219	15	not	not	RB
cord-015021-pol2qm74	6219	16	be	be	VB
cord-015021-pol2qm74	6219	17	used	use	VBN
cord-015021-pol2qm74	6219	18	in	in	IN
cord-015021-pol2qm74	6219	19	all	all	DT
cord-015021-pol2qm74	6219	20	seriously	seriously	RB
cord-015021-pol2qm74	6219	21	ill	ill	JJ
cord-015021-pol2qm74	6219	22	septic	septic	JJ
cord-015021-pol2qm74	6219	23	patients	patient	NNS
cord-015021-pol2qm74	6219	24	in	in	IN
cord-015021-pol2qm74	6219	25	the	the	DT
cord-015021-pol2qm74	6219	26	hospital	hospital	NN
cord-015021-pol2qm74	6219	27	?	?	.
cord-015021-pol2qm74	6220	1	In	in	IN
cord-015021-pol2qm74	6220	2	other	other	JJ
cord-015021-pol2qm74	6220	3	conditions	condition	NNS
cord-015021-pol2qm74	6220	4	such	such	JJ
cord-015021-pol2qm74	6220	5	as	as	IN
cord-015021-pol2qm74	6220	6	ARDS	ARDS	NNP
cord-015021-pol2qm74	6220	7	,	,	,
cord-015021-pol2qm74	6220	8	the	the	DT
cord-015021-pol2qm74	6220	9	success	success	NN
cord-015021-pol2qm74	6220	10	of	of	IN
cord-015021-pol2qm74	6220	11	protocol	protocol	NN
cord-015021-pol2qm74	6220	12	therapy	therapy	NN
cord-015021-pol2qm74	6220	13	is	be	VBZ
cord-015021-pol2qm74	6220	14	dependent	dependent	JJ
cord-015021-pol2qm74	6220	15	upon	upon	IN
cord-015021-pol2qm74	6220	16	measurable	measurable	JJ
cord-015021-pol2qm74	6220	17	goals	goal	NNS
cord-015021-pol2qm74	6220	18	such	such	JJ
cord-015021-pol2qm74	6220	19	as	as	IN
cord-015021-pol2qm74	6220	20	Pao	Pao	NNP
cord-015021-pol2qm74	6220	21	2	2	CD
cord-015021-pol2qm74	6220	22	and	and	CC
cord-015021-pol2qm74	6220	23	highest	high	JJS
cord-015021-pol2qm74	6220	24	plateau	plateau	NN
cord-015021-pol2qm74	6220	25	pressure	pressure	NN
cord-015021-pol2qm74	6220	26	,	,	,
cord-015021-pol2qm74	6220	27	while	while	IN
cord-015021-pol2qm74	6220	28	measurable	measurable	JJ
cord-015021-pol2qm74	6220	29	goals	goal	NNS
cord-015021-pol2qm74	6220	30	are	be	VBP
cord-015021-pol2qm74	6220	31	not	not	RB
cord-015021-pol2qm74	6220	32	as	as	RB
cord-015021-pol2qm74	6220	33	clear	clear	JJ
cord-015021-pol2qm74	6220	34	in	in	IN
cord-015021-pol2qm74	6220	35	choosing	choose	VBG
cord-015021-pol2qm74	6220	36	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6220	37	.	.	.
cord-015021-pol2qm74	6221	1	Based	base	VBN
cord-015021-pol2qm74	6221	2	on	on	IN
cord-015021-pol2qm74	6221	3	the	the	DT
cord-015021-pol2qm74	6221	4	above	above	JJ
cord-015021-pol2qm74	6221	5	confounding	confounding	JJ
cord-015021-pol2qm74	6221	6	issues	issue	NNS
cord-015021-pol2qm74	6221	7	,	,	,
cord-015021-pol2qm74	6221	8	a	a	DT
cord-015021-pol2qm74	6221	9	complex	complex	JJ
cord-015021-pol2qm74	6221	10	and	and	CC
cord-015021-pol2qm74	6221	11	extensive	extensive	JJ
cord-015021-pol2qm74	6221	12	algorithm	algorithm	NN
cord-015021-pol2qm74	6221	13	covering	cover	VBG
cord-015021-pol2qm74	6221	14	many	many	JJ
cord-015021-pol2qm74	6221	15	potential	potential	JJ
cord-015021-pol2qm74	6221	16	possibilities	possibility	NNS
cord-015021-pol2qm74	6221	17	of	of	IN
cord-015021-pol2qm74	6221	18	error	error	NN
cord-015021-pol2qm74	6221	19	and	and	CC
cord-015021-pol2qm74	6221	20	specific	specific	JJ
cord-015021-pol2qm74	6221	21	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6221	22	seems	seem	VBZ
cord-015021-pol2qm74	6221	23	impractical	impractical	JJ
cord-015021-pol2qm74	6221	24	;	;	:
cord-015021-pol2qm74	6221	25	however	however	RB
cord-015021-pol2qm74	6221	26	,	,	,
cord-015021-pol2qm74	6221	27	an	an	DT
cord-015021-pol2qm74	6221	28	algorithm	algorithm	NN
cord-015021-pol2qm74	6221	29	focusing	focus	VBG
cord-015021-pol2qm74	6221	30	on	on	IN
cord-015021-pol2qm74	6221	31	three	three	CD
cord-015021-pol2qm74	6221	32	to	to	TO
cord-015021-pol2qm74	6221	33	four	four	CD
cord-015021-pol2qm74	6221	34	major	major	JJ
cord-015021-pol2qm74	6221	35	common	common	JJ
cord-015021-pol2qm74	6221	36	errors	error	NNS
cord-015021-pol2qm74	6221	37	in	in	IN
cord-015021-pol2qm74	6221	38	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6221	39	selection	selection	NN
cord-015021-pol2qm74	6221	40	and	and	CC
cord-015021-pol2qm74	6221	41	dealing	deal	VBG
cord-015021-pol2qm74	6221	42	with	with	IN
cord-015021-pol2qm74	6221	43	classes	class	NNS
cord-015021-pol2qm74	6221	44	of	of	IN
cord-015021-pol2qm74	6221	45	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6221	46	is	be	VBZ
cord-015021-pol2qm74	6221	47	plausible	plausible	JJ
cord-015021-pol2qm74	6221	48	for	for	IN
cord-015021-pol2qm74	6221	49	inclusion	inclusion	NN
cord-015021-pol2qm74	6221	50	in	in	IN
cord-015021-pol2qm74	6221	51	sepsis	sepsis	NN
cord-015021-pol2qm74	6221	52	clinical	clinical	JJ
cord-015021-pol2qm74	6221	53	trials	trial	NNS
cord-015021-pol2qm74	6221	54	.	.	.
cord-015021-pol2qm74	6222	1	In	in	IN
cord-015021-pol2qm74	6222	2	this	this	DT
cord-015021-pol2qm74	6222	3	session	session	NN
cord-015021-pol2qm74	6222	4	we	-PRON-	PRP
cord-015021-pol2qm74	6222	5	will	will	MD
cord-015021-pol2qm74	6222	6	attempt	attempt	VB
cord-015021-pol2qm74	6222	7	to	to	TO
cord-015021-pol2qm74	6222	8	outline	outline	VB
cord-015021-pol2qm74	6222	9	the	the	DT
cord-015021-pol2qm74	6222	10	methodology	methodology	NN
cord-015021-pol2qm74	6222	11	of	of	IN
cord-015021-pol2qm74	6222	12	such	such	PDT
cord-015021-pol2qm74	6222	13	a	a	DT
cord-015021-pol2qm74	6222	14	future	future	JJ
cord-015021-pol2qm74	6222	15	study	study	NN
cord-015021-pol2qm74	6222	16	,	,	,
cord-015021-pol2qm74	6222	17	emphasizing	emphasize	VBG
cord-015021-pol2qm74	6222	18	the	the	DT
cord-015021-pol2qm74	6222	19	immense	immense	JJ
cord-015021-pol2qm74	6222	20	difficulties	difficulty	NNS
cord-015021-pol2qm74	6222	21	involved	involve	VBN
cord-015021-pol2qm74	6222	22	in	in	IN
cord-015021-pol2qm74	6222	23	its	-PRON-	PRP$
cord-015021-pol2qm74	6222	24	proper	proper	JJ
cord-015021-pol2qm74	6222	25	conduction	conduction	NN
cord-015021-pol2qm74	6222	26	including	include	VBG
cord-015021-pol2qm74	6222	27	:	:	:
cord-015021-pol2qm74	6222	28	design	design	NN
cord-015021-pol2qm74	6222	29	,	,	,
cord-015021-pol2qm74	6222	30	selection	selection	NN
cord-015021-pol2qm74	6222	31	of	of	IN
cord-015021-pol2qm74	6222	32	patients	patient	NNS
cord-015021-pol2qm74	6222	33	,	,	,
cord-015021-pol2qm74	6222	34	surgical	surgical	JJ
cord-015021-pol2qm74	6222	35	considerations	consideration	NNS
cord-015021-pol2qm74	6222	36	,	,	,
cord-015021-pol2qm74	6222	37	supportive	supportive	JJ
cord-015021-pol2qm74	6222	38	treatment	treatment	NN
cord-015021-pol2qm74	6222	39	,	,	,
cord-015021-pol2qm74	6222	40	the	the	DT
cord-015021-pol2qm74	6222	41	"	"	``
cord-015021-pol2qm74	6222	42	human	human	JJ
cord-015021-pol2qm74	6222	43	factor	factor	NN
cord-015021-pol2qm74	6222	44	"	"	''
cord-015021-pol2qm74	6222	45	and	and	CC
cord-015021-pol2qm74	6222	46	~nd	~nd	NNP
cord-015021-pol2qm74	6222	47	points	point	NNS
cord-015021-pol2qm74	6222	48	.	.	.
cord-015021-pol2qm74	6223	1	Only	only	RB
cord-015021-pol2qm74	6223	2	a	a	DT
cord-015021-pol2qm74	6223	3	close	close	JJ
cord-015021-pol2qm74	6223	4	cooperation	cooperation	NN
cord-015021-pol2qm74	6223	5	between	between	IN
cord-015021-pol2qm74	6223	6	a	a	DT
cord-015021-pol2qm74	6223	7	few	few	JJ
cord-015021-pol2qm74	6223	8	dedicated	dedicated	JJ
cord-015021-pol2qm74	6223	9	surgeons	surgeon	NNS
cord-015021-pol2qm74	6223	10	,	,	,
cord-015021-pol2qm74	6223	11	obsessively	obsessively	RB
cord-015021-pol2qm74	6223	12	studying	study	VBG
cord-015021-pol2qm74	6223	13	a	a	DT
cord-015021-pol2qm74	6223	14	large	large	JJ
cord-015021-pol2qm74	6223	15	number	number	NN
cord-015021-pol2qm74	6223	16	of	of	IN
cord-015021-pol2qm74	6223	17	well	well	RB
cord-015021-pol2qm74	6223	18	selected	selected	JJ
cord-015021-pol2qm74	6223	19	and	and	CC
cord-015021-pol2qm74	6223	20	stratified	stratified	JJ
cord-015021-pol2qm74	6223	21	patients	patient	NNS
cord-015021-pol2qm74	6223	22	over	over	IN
cord-015021-pol2qm74	6223	23	years	year	NNS
cord-015021-pol2qm74	6223	24	,	,	,
cord-015021-pol2qm74	6223	25	could	could	MD
cord-015021-pol2qm74	6223	26	make	make	VB
cord-015021-pol2qm74	6223	27	such	such	PDT
cord-015021-pol2qm74	6223	28	a	a	DT
cord-015021-pol2qm74	6223	29	study	study	NN
cord-015021-pol2qm74	6223	30	possible	possible	JJ
cord-015021-pol2qm74	6223	31	.	.	.
cord-015021-pol2qm74	6224	1	Algorithmis	Algorithmis	NNP
cord-015021-pol2qm74	6224	2	have	have	VBP
cord-015021-pol2qm74	6224	3	frequently	frequently	RB
cord-015021-pol2qm74	6224	4	been	be	VBN
cord-015021-pol2qm74	6224	5	mistaken	mistaken	JJ
cord-015021-pol2qm74	6224	6	for	for	IN
cord-015021-pol2qm74	6224	7	the	the	DT
cord-015021-pol2qm74	6224	8	graphic	graphic	JJ
cord-015021-pol2qm74	6224	9	format	format	NN
cord-015021-pol2qm74	6224	10	in	in	IN
cord-015021-pol2qm74	6224	11	which	which	WDT
cord-015021-pol2qm74	6224	12	they	-PRON-	PRP
cord-015021-pol2qm74	6224	13	are	be	VBP
cord-015021-pol2qm74	6224	14	presented	present	VBN
cord-015021-pol2qm74	6224	15	.	.	.
cord-015021-pol2qm74	6225	1	However	however	RB
cord-015021-pol2qm74	6225	2	,	,	,
cord-015021-pol2qm74	6225	3	an	an	DT
cord-015021-pol2qm74	6225	4	algorithm	algorithm	NN
cord-015021-pol2qm74	6225	5	is	be	VBZ
cord-015021-pol2qm74	6225	6	neither	neither	CC
cord-015021-pol2qm74	6225	7	a	a	DT
cord-015021-pol2qm74	6225	8	flow	flow	NN
cord-015021-pol2qm74	6225	9	chart	chart	NN
cord-015021-pol2qm74	6225	10	nor	nor	CC
cord-015021-pol2qm74	6225	11	a	a	DT
cord-015021-pol2qm74	6225	12	list	list	NN
cord-015021-pol2qm74	6225	13	of	of	IN
cord-015021-pol2qm74	6225	14	instructions	instruction	NNS
cord-015021-pol2qm74	6225	15	;	;	:
cord-015021-pol2qm74	6225	16	it	-PRON-	PRP
cord-015021-pol2qm74	6225	17	is	be	VBZ
cord-015021-pol2qm74	6225	18	a	a	DT
cord-015021-pol2qm74	6225	19	step	step	NN
cord-015021-pol2qm74	6225	20	-	-	HYPH
cord-015021-pol2qm74	6225	21	by	by	IN
cord-015021-pol2qm74	6225	22	-	-	HYPH
cord-015021-pol2qm74	6225	23	step	step	NN
cord-015021-pol2qm74	6225	24	approach	approach	NN
cord-015021-pol2qm74	6225	25	to	to	IN
cord-015021-pol2qm74	6225	26	solving	solve	VBG
cord-015021-pol2qm74	6225	27	a	a	DT
cord-015021-pol2qm74	6225	28	problem	problem	NN
cord-015021-pol2qm74	6225	29	.	.	.
cord-015021-pol2qm74	6226	1	Likewise	likewise	RB
cord-015021-pol2qm74	6226	2	,	,	,
cord-015021-pol2qm74	6226	3	a	a	DT
cord-015021-pol2qm74	6226	4	clinical	clinical	JJ
cord-015021-pol2qm74	6226	5	algorithm	algorithm	NN
cord-015021-pol2qm74	6226	6	is	be	VBZ
cord-015021-pol2qm74	6226	7	a	a	DT
cord-015021-pol2qm74	6226	8	step	step	NN
cord-015021-pol2qm74	6226	9	-	-	HYPH
cord-015021-pol2qm74	6226	10	by	by	IN
cord-015021-pol2qm74	6226	11	-	-	HYPH
cord-015021-pol2qm74	6226	12	step	step	NN
cord-015021-pol2qm74	6226	13	approach	approach	NN
cord-015021-pol2qm74	6226	14	to	to	IN
cord-015021-pol2qm74	6226	15	solving	solve	VBG
cord-015021-pol2qm74	6226	16	a	a	DT
cord-015021-pol2qm74	6226	17	clinical	clinical	JJ
cord-015021-pol2qm74	6226	18	problem	problem	NN
cord-015021-pol2qm74	6226	19	.	.	.
cord-015021-pol2qm74	6227	1	CAs	CAs	NNP
cord-015021-pol2qm74	6227	2	are	be	VBP
cord-015021-pol2qm74	6227	3	deterministic	deterministic	JJ
cord-015021-pol2qm74	6227	4	,	,	,
cord-015021-pol2qm74	6227	5	which	which	WDT
cord-015021-pol2qm74	6227	6	does	do	VBZ
cord-015021-pol2qm74	6227	7	not	not	RB
cord-015021-pol2qm74	6227	8	mean	mean	VB
cord-015021-pol2qm74	6227	9	that	that	IN
cord-015021-pol2qm74	6227	10	they	-PRON-	PRP
cord-015021-pol2qm74	6227	11	are	be	VBP
cord-015021-pol2qm74	6227	12	rigid	rigid	JJ
cord-015021-pol2qm74	6227	13	.	.	.
cord-015021-pol2qm74	6228	1	They	-PRON-	PRP
cord-015021-pol2qm74	6228	2	are	be	VBP
cord-015021-pol2qm74	6228	3	practical	practical	JJ
cord-015021-pol2qm74	6228	4	rather	rather	RB
cord-015021-pol2qm74	6228	5	than	than	IN
cord-015021-pol2qm74	6228	6	mathematical	mathematical	JJ
cord-015021-pol2qm74	6228	7	algorithms	algorithm	NNS
cord-015021-pol2qm74	6228	8	,	,	,
cord-015021-pol2qm74	6228	9	that	that	IN
cord-015021-pol2qm74	6228	10	tan	tan	NNP
cord-015021-pol2qm74	6228	11	be	be	VB
cord-015021-pol2qm74	6228	12	used	use	VBN
cord-015021-pol2qm74	6228	13	only	only	RB
cord-015021-pol2qm74	6228	14	with	with	IN
cord-015021-pol2qm74	6228	15	clinical	clinical	JJ
cord-015021-pol2qm74	6228	16	judgment	judgment	NN
cord-015021-pol2qm74	6228	17	,	,	,
cord-015021-pol2qm74	6228	18	and	and	CC
cord-015021-pol2qm74	6228	19	must	must	MD
cord-015021-pol2qm74	6228	20	be	be	VB
cord-015021-pol2qm74	6228	21	tailored	tailor	VBN
cord-015021-pol2qm74	6228	22	to	to	IN
cord-015021-pol2qm74	6228	23	each	each	DT
cord-015021-pol2qm74	6228	24	patient	patient	NN
cord-015021-pol2qm74	6228	25	.	.	.
cord-015021-pol2qm74	6229	1	There	there	EX
cord-015021-pol2qm74	6229	2	are	be	VBP
cord-015021-pol2qm74	6229	3	a	a	DT
cord-015021-pol2qm74	6229	4	number	number	NN
cord-015021-pol2qm74	6229	5	of	of	IN
cord-015021-pol2qm74	6229	6	types	type	NNS
cord-015021-pol2qm74	6229	7	of	of	IN
cord-015021-pol2qm74	6229	8	,	,	,
cord-015021-pol2qm74	6229	9	or	or	CC
cord-015021-pol2qm74	6229	10	uses	use	VBZ
cord-015021-pol2qm74	6229	11	for	for	IN
cord-015021-pol2qm74	6229	12	,	,	,
cord-015021-pol2qm74	6229	13	CAs	CAs	NNP
cord-015021-pol2qm74	6229	14	that	that	WDT
cord-015021-pol2qm74	6229	15	can	can	MD
cord-015021-pol2qm74	6229	16	improve	improve	VB
cord-015021-pol2qm74	6229	17	sepsis	sepsis	NN
cord-015021-pol2qm74	6229	18	management	management	NN
cord-015021-pol2qm74	6229	19	,	,	,
cord-015021-pol2qm74	6229	20	including	include	VBG
cord-015021-pol2qm74	6229	21	:	:	:
cord-015021-pol2qm74	6229	22	diagnostic	diagnostic	JJ
cord-015021-pol2qm74	6229	23	or	or	CC
cord-015021-pol2qm74	6229	24	severity	severity	NN
cord-015021-pol2qm74	6229	25	scorm	scorm	NNP
cord-015021-pol2qm74	6229	26	CAs	CAs	NNP
cord-015021-pol2qm74	6229	27	,	,	,
cord-015021-pol2qm74	6229	28	a	a	DT
cord-015021-pol2qm74	6229	29	management	management	NN
cord-015021-pol2qm74	6229	30	CA	CA	NNP
cord-015021-pol2qm74	6229	31	for	for	IN
cord-015021-pol2qm74	6229	32	managing	manage	VBG
cord-015021-pol2qm74	6229	33	sepsis	sepsis	NN
cord-015021-pol2qm74	6229	34	constructed	construct	VBN
cord-015021-pol2qm74	6229	35	according	accord	VBG
cord-015021-pol2qm74	6229	36	to	to	IN
cord-015021-pol2qm74	6229	37	recently	recently	RB
cord-015021-pol2qm74	6229	38	published	publish	VBN
cord-015021-pol2qm74	6229	39	standards	standard	NNS
cord-015021-pol2qm74	6229	40	for	for	IN
cord-015021-pol2qm74	6229	41	use	use	NN
cord-015021-pol2qm74	6229	42	in	in	IN
cord-015021-pol2qm74	6229	43	teaching	teaching	NN
cord-015021-pol2qm74	6229	44	research	research	NN
cord-015021-pol2qm74	6229	45	protocol	protocol	NN
cord-015021-pol2qm74	6229	46	algorithms	algorithm	NNS
cord-015021-pol2qm74	6229	47	that	that	WDT
cord-015021-pol2qm74	6229	48	must	must	MD
cord-015021-pol2qm74	6229	49	be	be	VB
cord-015021-pol2qm74	6229	50	used	use	VBN
cord-015021-pol2qm74	6229	51	to	to	TO
cord-015021-pol2qm74	6229	52	collect	collect	VB
cord-015021-pol2qm74	6229	53	data	datum	NNS
cord-015021-pol2qm74	6229	54	or	or	CC
cord-015021-pol2qm74	6229	55	guide	guide	NN
cord-015021-pol2qm74	6229	56	implementation	implementation	NN
cord-015021-pol2qm74	6229	57	of	of	IN
cord-015021-pol2qm74	6229	58	a	a	DT
cord-015021-pol2qm74	6229	59	clinical	clinical	JJ
cord-015021-pol2qm74	6229	60	trial	trial	NN
cord-015021-pol2qm74	6229	61	aimed	aim	VBN
cord-015021-pol2qm74	6229	62	at	at	IN
cord-015021-pol2qm74	6229	63	validating	validate	VBG
cord-015021-pol2qm74	6229	64	one	one	CD
cord-015021-pol2qm74	6229	65	or	or	CC
cord-015021-pol2qm74	6229	66	more	more	JJR
cord-015021-pol2qm74	6229	67	dicisions	dicision	NNS
cord-015021-pol2qm74	6229	68	in	in	IN
cord-015021-pol2qm74	6229	69	the	the	DT
cord-015021-pol2qm74	6229	70	management	management	NN
cord-015021-pol2qm74	6229	71	CA	CA	NNP
cord-015021-pol2qm74	6229	72	;	;	:
cord-015021-pol2qm74	6229	73	finally	finally	RB
cord-015021-pol2qm74	6229	74	,	,	,
cord-015021-pol2qm74	6229	75	protocol	protocol	NN
cord-015021-pol2qm74	6229	76	-	-	HYPH
cord-015021-pol2qm74	6229	77	style	style	NN
cord-015021-pol2qm74	6229	78	CAs	ca	NNS
cord-015021-pol2qm74	6229	79	drawn	draw	VBN
cord-015021-pol2qm74	6229	80	from	from	IN
cord-015021-pol2qm74	6229	81	the	the	DT
cord-015021-pol2qm74	6229	82	management	management	NN
cord-015021-pol2qm74	6229	83	CA	CA	NNP
cord-015021-pol2qm74	6229	84	and	and	CC
cord-015021-pol2qm74	6229	85	should	should	MD
cord-015021-pol2qm74	6229	86	be	be	VB
cord-015021-pol2qm74	6229	87	validated	validate	VBN
cord-015021-pol2qm74	6229	88	using	use	VBG
cord-015021-pol2qm74	6229	89	matching	match	VBG
cord-015021-pol2qm74	6229	90	outcome	outcome	NN
cord-015021-pol2qm74	6229	91	studies	study	NNS
cord-015021-pol2qm74	6229	92	.	.	.
cord-015021-pol2qm74	6229	93	 	 	_SP
cord-015021-pol2qm74	6230	1	Organisational	organisational	JJ
cord-015021-pol2qm74	6230	2	problems	problem	NNS
cord-015021-pol2qm74	6230	3	peculiar	peculiar	JJ
cord-015021-pol2qm74	6230	4	to	to	IN
cord-015021-pol2qm74	6230	5	multicentre	multicentre	NNP
cord-015021-pol2qm74	6230	6	trials	trial	NNS
cord-015021-pol2qm74	6231	1	The	the	DT
cord-015021-pol2qm74	6231	2	organisation	organisation	NN
cord-015021-pol2qm74	6231	3	of	of	IN
cord-015021-pol2qm74	6231	4	any	any	DT
cord-015021-pol2qm74	6231	5	randomised	randomised	JJ
cord-015021-pol2qm74	6231	6	clinical	clinical	JJ
cord-015021-pol2qm74	6231	7	trial	trial	NN
cord-015021-pol2qm74	6231	8	is	be	VBZ
cord-015021-pol2qm74	6231	9	fraught	fraught	JJ
cord-015021-pol2qm74	6231	10	with	with	IN
cord-015021-pol2qm74	6231	11	difficulties	difficulty	NNS
cord-015021-pol2qm74	6231	12	,	,	,
cord-015021-pol2qm74	6231	13	and	and	CC
cord-015021-pol2qm74	6231	14	that	that	DT
cord-015021-pol2qm74	6231	15	of	of	IN
cord-015021-pol2qm74	6231	16	a	a	DT
cord-015021-pol2qm74	6231	17	multicentre	multicentre	NNP
cord-015021-pol2qm74	6231	18	trial	trial	NN
cord-015021-pol2qm74	6231	19	particularly	particularly	RB
cord-015021-pol2qm74	6231	20	so	so	RB
cord-015021-pol2qm74	6231	21	.	.	.
cord-015021-pol2qm74	6232	1	There	there	EX
cord-015021-pol2qm74	6232	2	are	be	VBP
cord-015021-pol2qm74	6232	3	problems	problem	NNS
cord-015021-pol2qm74	6232	4	associated	associate	VBN
cord-015021-pol2qm74	6232	5	not	not	RB
cord-015021-pol2qm74	6232	6	only	only	RB
cord-015021-pol2qm74	6232	7	with	with	IN
cord-015021-pol2qm74	6232	8	the	the	DT
cord-015021-pol2qm74	6232	9	principles	principle	NNS
cord-015021-pol2qm74	6232	10	on	on	IN
cord-015021-pol2qm74	6232	11	which	which	WDT
cord-015021-pol2qm74	6232	12	the	the	DT
cord-015021-pol2qm74	6232	13	investigation	investigation	NN
cord-015021-pol2qm74	6232	14	is	be	VBZ
cord-015021-pol2qm74	6232	15	based	base	VBN
cord-015021-pol2qm74	6232	16	but	but	CC
cord-015021-pol2qm74	6232	17	also	also	RB
cord-015021-pol2qm74	6232	18	with	with	IN
cord-015021-pol2qm74	6232	19	the	the	DT
cord-015021-pol2qm74	6232	20	detailed	detailed	JJ
cord-015021-pol2qm74	6232	21	organisation	organisation	NN
cord-015021-pol2qm74	6232	22	and	and	CC
cord-015021-pol2qm74	6232	23	analysis	analysis	NN
cord-015021-pol2qm74	6232	24	.	.	.
cord-015021-pol2qm74	6233	1	Are	be	VBP
cord-015021-pol2qm74	6233	2	all	all	PDT
cord-015021-pol2qm74	6233	3	the	the	DT
cord-015021-pol2qm74	6233	4	participants	participant	NNS
cord-015021-pol2qm74	6233	5	truly	truly	RB
cord-015021-pol2qm74	6233	6	unbiased	unbiased	JJ
cord-015021-pol2qm74	6233	7	about	about	IN
cord-015021-pol2qm74	6233	8	the	the	DT
cord-015021-pol2qm74	6233	9	relative	relative	JJ
cord-015021-pol2qm74	6233	10	merits	merit	NNS
cord-015021-pol2qm74	6233	11	of	of	IN
cord-015021-pol2qm74	6233	12	the	the	DT
cord-015021-pol2qm74	6233	13	regimens	regimen	NNS
cord-015021-pol2qm74	6233	14	being	be	VBG
cord-015021-pol2qm74	6233	15	studied	study	VBN
cord-015021-pol2qm74	6233	16	?	?	.
cord-015021-pol2qm74	6234	1	Is	be	VBZ
cord-015021-pol2qm74	6234	2	like	like	IN
cord-015021-pol2qm74	6234	3	being	be	VBG
cord-015021-pol2qm74	6234	4	compared	compare	VBN
cord-015021-pol2qm74	6234	5	with	with	IN
cord-015021-pol2qm74	6234	6	like	like	UH
cord-015021-pol2qm74	6234	7	-are	-are	:
cord-015021-pol2qm74	6234	8	all	all	PDT
cord-015021-pol2qm74	6234	9	the	the	DT
cord-015021-pol2qm74	6234	10	end	end	NN
cord-015021-pol2qm74	6234	11	points	point	NNS
cord-015021-pol2qm74	6234	12	and	and	CC
cord-015021-pol2qm74	6234	13	the	the	DT
cord-015021-pol2qm74	6234	14	standards	standard	NNS
cord-015021-pol2qm74	6234	15	for	for	IN
cord-015021-pol2qm74	6234	16	measuring	measure	VBG
cord-015021-pol2qm74	6234	17	them	-PRON-	PRP
cord-015021-pol2qm74	6234	18	clearly	clearly	RB
cord-015021-pol2qm74	6234	19	defined	define	VBN
cord-015021-pol2qm74	6234	20	so	so	IN
cord-015021-pol2qm74	6234	21	that	that	IN
cord-015021-pol2qm74	6234	22	they	-PRON-	PRP
cord-015021-pol2qm74	6234	23	can	can	MD
cord-015021-pol2qm74	6234	24	not	not	RB
cord-015021-pol2qm74	6234	25	be	be	VB
cord-015021-pol2qm74	6234	26	misunderstood	misunderstand	VBN
cord-015021-pol2qm74	6234	27	?	?	.
cord-015021-pol2qm74	6235	1	Are	be	VBP
cord-015021-pol2qm74	6235	2	all	all	DT
cord-015021-pol2qm74	6235	3	eligible	eligible	JJ
cord-015021-pol2qm74	6235	4	patients	patient	NNS
cord-015021-pol2qm74	6235	5	being	be	VBG
cord-015021-pol2qm74	6235	6	studied	study	VBN
cord-015021-pol2qm74	6235	7	,	,	,
cord-015021-pol2qm74	6235	8	and	and	CC
cord-015021-pol2qm74	6235	9	their	-PRON-	PRP$
cord-015021-pol2qm74	6235	10	results	result	NNS
cord-015021-pol2qm74	6235	11	reported	report	VBN
cord-015021-pol2qm74	6235	12	?	?	.
cord-015021-pol2qm74	6236	1	Is	be	VBZ
cord-015021-pol2qm74	6236	2	truly	truly	RB
cord-015021-pol2qm74	6236	3	informed	informed	JJ
cord-015021-pol2qm74	6236	4	consent	consent	NN
cord-015021-pol2qm74	6236	5	being	be	VBG
cord-015021-pol2qm74	6236	6	sought	seek	VBN
cord-015021-pol2qm74	6236	7	that	that	WDT
cord-015021-pol2qm74	6236	8	will	will	MD
cord-015021-pol2qm74	6236	9	satisfy	satisfy	VB
cord-015021-pol2qm74	6236	10	not	not	RB
cord-015021-pol2qm74	6236	11	only	only	RB
cord-015021-pol2qm74	6236	12	the	the	DT
cord-015021-pol2qm74	6236	13	patient	patient	NN
cord-015021-pol2qm74	6236	14	's	's	POS
cord-015021-pol2qm74	6236	15	right	right	NN
cord-015021-pol2qm74	6236	16	to	to	TO
cord-015021-pol2qm74	6236	17	choose	choose	VB
cord-015021-pol2qm74	6236	18	what	what	WP
cord-015021-pol2qm74	6236	19	happens	happen	VBZ
cord-015021-pol2qm74	6236	20	to	to	IN
cord-015021-pol2qm74	6236	21	him	-PRON-	PRP
cord-015021-pol2qm74	6236	22	,	,	,
cord-015021-pol2qm74	6236	23	but	but	CC
cord-015021-pol2qm74	6236	24	also	also	RB
cord-015021-pol2qm74	6236	25	the	the	DT
cord-015021-pol2qm74	6236	26	law	law	NN
cord-015021-pol2qm74	6236	27	of	of	IN
cord-015021-pol2qm74	6236	28	the	the	DT
cord-015021-pol2qm74	6236	29	land	land	NN
cord-015021-pol2qm74	6236	30	?	?	.
cord-015021-pol2qm74	6237	1	And	and	CC
cord-015021-pol2qm74	6237	2	,	,	,
cord-015021-pol2qm74	6237	3	finally	finally	RB
cord-015021-pol2qm74	6237	4	,	,	,
cord-015021-pol2qm74	6237	5	how	how	WRB
cord-015021-pol2qm74	6237	6	can	can	MD
cord-015021-pol2qm74	6237	7	the	the	DT
cord-015021-pol2qm74	6237	8	participants	participant	NNS
cord-015021-pol2qm74	6237	9	be	be	VB
cord-015021-pol2qm74	6237	10	sure	sure	JJ
cord-015021-pol2qm74	6237	11	that	that	IN
cord-015021-pol2qm74	6237	12	the	the	DT
cord-015021-pol2qm74	6237	13	trial	trial	NN
cord-015021-pol2qm74	6237	14	will	will	MD
cord-015021-pol2qm74	6237	15	be	be	VB
cord-015021-pol2qm74	6237	16	stopped	stop	VBN
cord-015021-pol2qm74	6237	17	at	at	IN
cord-015021-pol2qm74	6237	18	the	the	DT
cord-015021-pol2qm74	6237	19	right	right	JJ
cord-015021-pol2qm74	6237	20	time	time	NN
cord-015021-pol2qm74	6237	21	,	,	,
cord-015021-pol2qm74	6237	22	to	to	TO
cord-015021-pol2qm74	6237	23	ensure	ensure	VB
cord-015021-pol2qm74	6237	24	that	that	IN
cord-015021-pol2qm74	6237	25	no	no	DT
cord-015021-pol2qm74	6237	26	treatment	treatment	NN
cord-015021-pol2qm74	6237	27	is	be	VBZ
cord-015021-pol2qm74	6237	28	given	give	VBN
cord-015021-pol2qm74	6237	29	to	to	IN
cord-015021-pol2qm74	6237	30	any	any	DT
cord-015021-pol2qm74	6237	31	patient	patient	NN
cord-015021-pol2qm74	6237	32	that	that	WDT
cord-015021-pol2qm74	6237	33	might	may	MD
cord-015021-pol2qm74	6237	34	be	be	VB
cord-015021-pol2qm74	6237	35	harmful	harmful	JJ
cord-015021-pol2qm74	6237	36	?	?	.
cord-015021-pol2qm74	6238	1	These	these	DT
cord-015021-pol2qm74	6238	2	questions	question	NNS
cord-015021-pol2qm74	6238	3	may	may	MD
cord-015021-pol2qm74	6238	4	seem	seem	VB
cord-015021-pol2qm74	6238	5	insoluble	insoluble	JJ
cord-015021-pol2qm74	6238	6	,	,	,
cord-015021-pol2qm74	6238	7	but	but	CC
cord-015021-pol2qm74	6238	8	until	until	IN
cord-015021-pol2qm74	6238	9	we	-PRON-	PRP
cord-015021-pol2qm74	6238	10	tackle	tackle	VBP
cord-015021-pol2qm74	6238	11	them	-PRON-	PRP
cord-015021-pol2qm74	6238	12	we	-PRON-	PRP
cord-015021-pol2qm74	6238	13	shall	shall	MD
cord-015021-pol2qm74	6238	14	never	never	RB
cord-015021-pol2qm74	6238	15	be	be	VB
cord-015021-pol2qm74	6238	16	certain	certain	JJ
cord-015021-pol2qm74	6238	17	.	.	.
cord-015021-pol2qm74	6239	1	Dr.	Dr.	NNP
cord-015021-pol2qm74	6240	1	M.	M.	NNP
cord-015021-pol2qm74	6240	2	Ev	Ev	NNP
cord-015021-pol2qm74	6240	3	~	~	NNP
cord-015021-pol2qm74	6240	4	s	s	NNP
cord-015021-pol2qm74	6240	5	,	,	,
cord-015021-pol2qm74	6240	6	Scar	Scar	NNP
cord-015021-pol2qm74	6240	7	~	~	NFP
cord-015021-pol2qm74	6240	8	mu~	mu~	NN
cord-015021-pol2qm74	6240	9	Hospital	Hospital	NNP
cord-015021-pol2qm74	6240	10	,	,	,
cord-015021-pol2qm74	6240	11	Scarborough	Scarborough	NNP
cord-015021-pol2qm74	6240	12	,	,	,
cord-015021-pol2qm74	6240	13	NonhYo	NonhYo	NNP
cord-015021-pol2qm74	6240	14	~	~	NFP
cord-015021-pol2qm74	6240	15	s~	s~	CD
cord-015021-pol2qm74	6240	16	Y0126QL	Y0126QL	NNP
cord-015021-pol2qm74	6240	17	,	,	,
cord-015021-pol2qm74	6241	1	U.K.	U.K.	NNP
cord-015021-pol2qm74	6241	2	Increasing	increase	VBG
cord-015021-pol2qm74	6241	3	knowledge	knowledge	NN
cord-015021-pol2qm74	6241	4	of	of	IN
cord-015021-pol2qm74	6241	5	the	the	DT
cord-015021-pol2qm74	6241	6	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	6241	7	of	of	IN
cord-015021-pol2qm74	6241	8	sepsis	sepsis	NN
cord-015021-pol2qm74	6241	9	and	and	CC
cord-015021-pol2qm74	6241	10	septic	septic	JJ
cord-015021-pol2qm74	6241	11	shock	shock	NN
cord-015021-pol2qm74	6241	12	has	have	VBZ
cord-015021-pol2qm74	6241	13	led	lead	VBN
cord-015021-pol2qm74	6241	14	to	to	IN
cord-015021-pol2qm74	6241	15	the	the	DT
cord-015021-pol2qm74	6241	16	development	development	NN
cord-015021-pol2qm74	6241	17	of	of	IN
cord-015021-pol2qm74	6241	18	many	many	JJ
cord-015021-pol2qm74	6241	19	new	new	JJ
cord-015021-pol2qm74	6241	20	therapies	therapy	NNS
cord-015021-pol2qm74	6241	21	and	and	CC
cord-015021-pol2qm74	6241	22	technologies	technology	NNS
cord-015021-pol2qm74	6241	23	capable	capable	JJ
cord-015021-pol2qm74	6241	24	of	of	IN
cord-015021-pol2qm74	6241	25	preventing	prevent	VBG
cord-015021-pol2qm74	6241	26	,	,	,
cord-015021-pol2qm74	6241	27	blocking	block	VBG
cord-015021-pol2qm74	6241	28	or	or	CC
cord-015021-pol2qm74	6241	29	even	even	RB
cord-015021-pol2qm74	6241	30	reversing	reverse	VBG
cord-015021-pol2qm74	6241	31	the	the	DT
cord-015021-pol2qm74	6241	32	deleterious	deleterious	JJ
cord-015021-pol2qm74	6241	33	cycle	cycle	NN
cord-015021-pol2qm74	6241	34	of	of	IN
cord-015021-pol2qm74	6241	35	events	event	NNS
cord-015021-pol2qm74	6241	36	.	.	.
cord-015021-pol2qm74	6242	1	Recent	recent	JJ
cord-015021-pol2qm74	6242	2	results	result	NNS
cord-015021-pol2qm74	6242	3	of	of	IN
cord-015021-pol2qm74	6242	4	subsequent	subsequent	JJ
cord-015021-pol2qm74	6242	5	multicenter	multicenter	JJ
cord-015021-pol2qm74	6242	6	trials	trial	NNS
cord-015021-pol2qm74	6242	7	testing	test	VBG
cord-015021-pol2qm74	6242	8	some	some	DT
cord-015021-pol2qm74	6242	9	novel	novel	JJ
cord-015021-pol2qm74	6242	10	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6242	11	drugs	drug	NNS
cord-015021-pol2qm74	6242	12	,	,	,
cord-015021-pol2qm74	6242	13	however	however	RB
cord-015021-pol2qm74	6242	14	,	,	,
cord-015021-pol2qm74	6242	15	did	do	VBD
cord-015021-pol2qm74	6242	16	not	not	RB
cord-015021-pol2qm74	6242	17	confirm	confirm	VB
cord-015021-pol2qm74	6242	18	the	the	DT
cord-015021-pol2qm74	6242	19	promising	promising	NN
cord-015021-pol2qm74	6242	20	sometimes	sometimes	RB
cord-015021-pol2qm74	6242	21	overwhelming	overwhelming	JJ
cord-015021-pol2qm74	6242	22	effects	effect	NNS
cord-015021-pol2qm74	6242	23	obtained	obtain	VBN
cord-015021-pol2qm74	6242	24	experimentally	experimentally	RB
cord-015021-pol2qm74	6242	25	.	.	.
cord-015021-pol2qm74	6243	1	It	-PRON-	PRP
cord-015021-pol2qm74	6243	2	is	be	VBZ
cord-015021-pol2qm74	6243	3	postulated	postulate	VBN
cord-015021-pol2qm74	6243	4	that	that	IN
cord-015021-pol2qm74	6243	5	this	this	DT
cord-015021-pol2qm74	6243	6	is	be	VBZ
cord-015021-pol2qm74	6243	7	largely	largely	RB
cord-015021-pol2qm74	6243	8	due	due	JJ
cord-015021-pol2qm74	6243	9	to	to	IN
cord-015021-pol2qm74	6243	10	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6243	11	design	design	NN
cord-015021-pol2qm74	6243	12	and	and	CC
cord-015021-pol2qm74	6243	13	conduct	conduct	NN
cord-015021-pol2qm74	6243	14	of	of	IN
cord-015021-pol2qm74	6243	15	multicenter	multicenter	JJ
cord-015021-pol2qm74	6243	16	trials	trial	NNS
cord-015021-pol2qm74	6243	17	as	as	IN
cord-015021-pol2qm74	6243	18	currently	currently	RB
cord-015021-pol2qm74	6243	19	performed	perform	VBN
cord-015021-pol2qm74	6243	20	.	.	.
cord-015021-pol2qm74	6244	1	One	one	CD
cord-015021-pol2qm74	6244	2	of	of	IN
cord-015021-pol2qm74	6244	3	the	the	DT
cord-015021-pol2qm74	6244	4	shortcomings	shortcoming	NNS
cord-015021-pol2qm74	6244	5	emphasized	emphasize	VBN
cord-015021-pol2qm74	6244	6	in	in	IN
cord-015021-pol2qm74	6244	7	this	this	DT
cord-015021-pol2qm74	6244	8	paper	paper	NN
cord-015021-pol2qm74	6244	9	is	be	VBZ
cord-015021-pol2qm74	6244	10	the	the	DT
cord-015021-pol2qm74	6244	11	"	"	``
cord-015021-pol2qm74	6244	12	treatment	treatment	NN
cord-015021-pol2qm74	6244	13	mix	mix	NN
cord-015021-pol2qm74	6244	14	"	"	''
cord-015021-pol2qm74	6244	15	problem	problem	NN
cord-015021-pol2qm74	6244	16	.	.	.
cord-015021-pol2qm74	6245	1	Multicenter	multicenter	JJ
cord-015021-pol2qm74	6245	2	trials	trial	NNS
cord-015021-pol2qm74	6245	3	in	in	IN
cord-015021-pol2qm74	6245	4	sepsis	sepsis	NN
cord-015021-pol2qm74	6245	5	are	be	VBP
cord-015021-pol2qm74	6245	6	performed	perform	VBN
cord-015021-pol2qm74	6245	7	because	because	IN
cord-015021-pol2qm74	6245	8	no	no	DT
cord-015021-pol2qm74	6245	9	single	single	JJ
cord-015021-pol2qm74	6245	10	center	center	NN
cord-015021-pol2qm74	6245	11	is	be	VBZ
cord-015021-pol2qm74	6245	12	able	able	JJ
cord-015021-pol2qm74	6245	13	to	to	TO
cord-015021-pol2qm74	6245	14	recruit	recruit	VB
cord-015021-pol2qm74	6245	15	the	the	DT
cord-015021-pol2qm74	6245	16	necessary	necessary	JJ
cord-015021-pol2qm74	6245	17	number	number	NN
cord-015021-pol2qm74	6245	18	of	of	IN
cord-015021-pol2qm74	6245	19	eligible	eligible	JJ
cord-015021-pol2qm74	6245	20	subjects	subject	NNS
cord-015021-pol2qm74	6245	21	within	within	IN
cord-015021-pol2qm74	6245	22	a	a	DT
cord-015021-pol2qm74	6245	23	reasonable	reasonable	JJ
cord-015021-pol2qm74	6245	24	time	time	NN
cord-015021-pol2qm74	6245	25	.	.	.
cord-015021-pol2qm74	6246	1	Each	each	DT
cord-015021-pol2qm74	6246	2	single	single	JJ
cord-015021-pol2qm74	6246	3	center	center	NN
cord-015021-pol2qm74	6246	4	(	(	-LRB-
cord-015021-pol2qm74	6246	5	ICU	ICU	NNP
cord-015021-pol2qm74	6246	6	)	)	-RRB-
cord-015021-pol2qm74	6246	7	has	have	VBZ
cord-015021-pol2qm74	6246	8	its	-PRON-	PRP$
cord-015021-pol2qm74	6246	9	own	own	JJ
cord-015021-pol2qm74	6246	10	individual	individual	JJ
cord-015021-pol2qm74	6246	11	policy	policy	NN
cord-015021-pol2qm74	6246	12	which	which	WDT
cord-015021-pol2qm74	6246	13	can	can	MD
cord-015021-pol2qm74	6246	14	not	not	RB
cord-015021-pol2qm74	6246	15	be	be	VB
cord-015021-pol2qm74	6246	16	standardized	standardize	VBN
cord-015021-pol2qm74	6246	17	for	for	IN
cord-015021-pol2qm74	6246	18	the	the	DT
cord-015021-pol2qm74	6246	19	trial	trial	NN
cord-015021-pol2qm74	6246	20	(	(	-LRB-
cord-015021-pol2qm74	6246	21	treatment	treatment	NN
cord-015021-pol2qm74	6246	22	mix	mix	NN
cord-015021-pol2qm74	6246	23	)	)	-RRB-
cord-015021-pol2qm74	6246	24	.	.	.
cord-015021-pol2qm74	6247	1	Even	even	RB
cord-015021-pol2qm74	6247	2	if	if	IN
cord-015021-pol2qm74	6247	3	we	-PRON-	PRP
cord-015021-pol2qm74	6247	4	ascribe	ascribe	VBP
cord-015021-pol2qm74	6247	5	that	that	IN
cord-015021-pol2qm74	6247	6	each	each	DT
cord-015021-pol2qm74	6247	7	ICU	ICU	NNP
cord-015021-pol2qm74	6247	8	did	do	VBD
cord-015021-pol2qm74	6247	9	the	the	DT
cord-015021-pol2qm74	6247	10	"	"	``
cord-015021-pol2qm74	6247	11	best	good	JJS
cord-015021-pol2qm74	6247	12	"	"	''
cord-015021-pol2qm74	6247	13	for	for	IN
cord-015021-pol2qm74	6247	14	their	-PRON-	PRP$
cord-015021-pol2qm74	6247	15	patients	patient	NNS
cord-015021-pol2qm74	6247	16	,	,	,
cord-015021-pol2qm74	6247	17	it	-PRON-	PRP
cord-015021-pol2qm74	6247	18	is	be	VBZ
cord-015021-pol2qm74	6247	19	highly	highly	RB
cord-015021-pol2qm74	6247	20	probable	probable	JJ
cord-015021-pol2qm74	6247	21	that	that	IN
cord-015021-pol2qm74	6247	22	the	the	DT
cord-015021-pol2qm74	6247	23	outcome	outcome	NN
cord-015021-pol2qm74	6247	24	differs	differ	VBZ
cord-015021-pol2qm74	6247	25	between	between	IN
cord-015021-pol2qm74	6247	26	the	the	DT
cord-015021-pol2qm74	6247	27	ICUs	ICUs	NNP
cord-015021-pol2qm74	6247	28	.	.	.
cord-015021-pol2qm74	6248	1	This	this	DT
cord-015021-pol2qm74	6248	2	translates	translate	VBZ
cord-015021-pol2qm74	6248	3	to	to	IN
cord-015021-pol2qm74	6248	4	the	the	DT
cord-015021-pol2qm74	6248	5	effect	effect	NN
cord-015021-pol2qm74	6248	6	of	of	IN
cord-015021-pol2qm74	6248	7	the	the	DT
cord-015021-pol2qm74	6248	8	new	new	JJ
cord-015021-pol2qm74	6248	9	therapy	therapy	NN
cord-015021-pol2qm74	6248	10	under	under	IN
cord-015021-pol2qm74	6248	11	investigation	investigation	NN
cord-015021-pol2qm74	6248	12	.	.	.
cord-015021-pol2qm74	6248	13	]	]	-RRB-
cord-015021-pol2qm74	6249	1	t	t	NNP
cord-015021-pol2qm74	6249	2	is	be	VBZ
cord-015021-pol2qm74	6249	3	therefore	therefore	RB
cord-015021-pol2qm74	6249	4	worthwhile	worthwhile	JJ
cord-015021-pol2qm74	6249	5	to	to	TO
cord-015021-pol2qm74	6249	6	consider	consider	VB
cord-015021-pol2qm74	6249	7	that	that	IN
cord-015021-pol2qm74	6249	8	ICUs	ICUs	NNP
cord-015021-pol2qm74	6249	9	must	must	MD
cord-015021-pol2qm74	6249	10	first	first	RB
cord-015021-pol2qm74	6249	11	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6249	12	a	a	DT
cord-015021-pol2qm74	6249	13	certain	certain	JJ
cord-015021-pol2qm74	6249	14	standard	standard	NN
cord-015021-pol2qm74	6249	15	based	base	VBN
cord-015021-pol2qm74	6249	16	on	on	IN
cord-015021-pol2qm74	6249	17	the	the	DT
cord-015021-pol2qm74	6249	18	patients	patient	NNS
cord-015021-pol2qm74	6249	19	'	'	POS
cord-015021-pol2qm74	6249	20	outcome	outcome	NN
cord-015021-pol2qm74	6249	21	(	(	-LRB-
cord-015021-pol2qm74	6249	22	audit	audit	NN
cord-015021-pol2qm74	6249	23	)	)	-RRB-
cord-015021-pol2qm74	6249	24	before	before	IN
cord-015021-pol2qm74	6249	25	becoming	become	VBG
cord-015021-pol2qm74	6249	26	accepted	accept	VBN
cord-015021-pol2qm74	6249	27	as	as	IN
cord-015021-pol2qm74	6249	28	a	a	DT
cord-015021-pol2qm74	6249	29	participating	participate	VBG
cord-015021-pol2qm74	6249	30	center	center	NN
cord-015021-pol2qm74	6249	31	.	.	.
cord-015021-pol2qm74	6250	1	This	this	DT
cord-015021-pol2qm74	6250	2	prerequisite	prerequisite	NN
cord-015021-pol2qm74	6250	3	ensures	ensure	VBZ
cord-015021-pol2qm74	6250	4	comparable	comparable	JJ
cord-015021-pol2qm74	6250	5	quality	quality	NN
cord-015021-pol2qm74	6250	6	between	between	IN
cord-015021-pol2qm74	6250	7	participating	participate	VBG
cord-015021-pol2qm74	6250	8	centers	center	NNS
cord-015021-pol2qm74	6250	9	,	,	,
cord-015021-pol2qm74	6250	10	led	lead	VBD
cord-015021-pol2qm74	6250	11	to	to	IN
cord-015021-pol2qm74	6250	12	the	the	DT
cord-015021-pol2qm74	6250	13	reduction	reduction	NN
cord-015021-pol2qm74	6250	14	of	of	IN
cord-015021-pol2qm74	6250	15	"	"	``
cord-015021-pol2qm74	6250	16	noise	noise	NN
cord-015021-pol2qm74	6250	17	level	level	NN
cord-015021-pol2qm74	6250	18	"	"	''
cord-015021-pol2qm74	6250	19	and	and	CC
cord-015021-pol2qm74	6250	20	increases	increase	VBZ
cord-015021-pol2qm74	6250	21	the	the	DT
cord-015021-pol2qm74	6250	22	probability	probability	NN
cord-015021-pol2qm74	6250	23	of	of	IN
cord-015021-pol2qm74	6250	24	positive	positive	JJ
cord-015021-pol2qm74	6250	25	study	study	NN
cord-015021-pol2qm74	6250	26	results	result	NNS
cord-015021-pol2qm74	6250	27	.	.	.
cord-015021-pol2qm74	6251	1	The	the	DT
cord-015021-pol2qm74	6251	2	RIYADH	RIYADH	NNP
cord-015021-pol2qm74	6251	3	-	-	HYPH
cord-015021-pol2qm74	6251	4	ICU	ICU	NNP
cord-015021-pol2qm74	6251	5	program	program	NN
cord-015021-pol2qm74	6251	6	based	base	VBN
cord-015021-pol2qm74	6251	7	on	on	IN
cord-015021-pol2qm74	6251	8	standard	standard	JJ
cord-015021-pol2qm74	6251	9	mortality	mortality	NN
cord-015021-pol2qm74	6251	10	ratios	ratio	NNS
cord-015021-pol2qm74	6251	11	is	be	VBZ
cord-015021-pol2qm74	6251	12	recommended	recommend	VBN
cord-015021-pol2qm74	6251	13	as	as	IN
cord-015021-pol2qm74	6251	14	an	an	DT
cord-015021-pol2qm74	6251	15	audit	audit	NN
cord-015021-pol2qm74	6251	16	instrument	instrument	NN
cord-015021-pol2qm74	6251	17	.	.	.
cord-015021-pol2qm74	6252	1	During	during	IN
cord-015021-pol2qm74	6252	2	the	the	DT
cord-015021-pol2qm74	6252	3	last	last	JJ
cord-015021-pol2qm74	6252	4	decade	decade	NN
cord-015021-pol2qm74	6252	5	most	most	RBS
cord-015021-pol2qm74	6252	6	clinical	clinical	JJ
cord-015021-pol2qm74	6252	7	trials	trial	NNS
cord-015021-pol2qm74	6252	8	of	of	IN
cord-015021-pol2qm74	6252	9	potential	potential	JJ
cord-015021-pol2qm74	6252	10	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6252	11	agents	agent	NNS
cord-015021-pol2qm74	6252	12	in	in	IN
cord-015021-pol2qm74	6252	13	systemic	systemic	JJ
cord-015021-pol2qm74	6252	14	sepsis	sepsis	NN
cord-015021-pol2qm74	6252	15	have	have	VBP
cord-015021-pol2qm74	6252	16	failed	fail	VBN
cord-015021-pol2qm74	6252	17	to	to	TO
cord-015021-pol2qm74	6252	18	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6252	19	benefit	benefit	NN
cord-015021-pol2qm74	6252	20	from	from	IN
cord-015021-pol2qm74	6252	21	the	the	DT
cord-015021-pol2qm74	6252	22	drug	drug	NN
cord-015021-pol2qm74	6252	23	under	under	IN
cord-015021-pol2qm74	6252	24	study	study	NN
cord-015021-pol2qm74	6252	25	.	.	.
cord-015021-pol2qm74	6253	1	Although	although	IN
cord-015021-pol2qm74	6253	2	in	in	IN
cord-015021-pol2qm74	6253	3	many	many	JJ
cord-015021-pol2qm74	6253	4	instances	instance	NNS
cord-015021-pol2qm74	6253	5	it	-PRON-	PRP
cord-015021-pol2qm74	6253	6	is	be	VBZ
cord-015021-pol2qm74	6253	7	entirely	entirely	RB
cord-015021-pol2qm74	6253	8	possible	possible	JJ
cord-015021-pol2qm74	6253	9	that	that	IN
cord-015021-pol2qm74	6253	10	the	the	DT
cord-015021-pol2qm74	6253	11	agent	agent	NN
cord-015021-pol2qm74	6253	12	in	in	IN
cord-015021-pol2qm74	6253	13	question	question	NN
cord-015021-pol2qm74	6253	14	does	do	VBZ
cord-015021-pol2qm74	6253	15	not	not	RB
cord-015021-pol2qm74	6253	16	have	have	VB
cord-015021-pol2qm74	6253	17	clinical	clinical	JJ
cord-015021-pol2qm74	6253	18	efficacy	efficacy	NN
cord-015021-pol2qm74	6253	19	,	,	,
cord-015021-pol2qm74	6253	20	an	an	DT
cord-015021-pol2qm74	6253	21	equally	equally	RB
cord-015021-pol2qm74	6253	22	plausible	plausible	JJ
cord-015021-pol2qm74	6253	23	explanation	explanation	NN
cord-015021-pol2qm74	6253	24	for	for	IN
cord-015021-pol2qm74	6253	25	the	the	DT
cord-015021-pol2qm74	6253	26	multitude	multitude	NN
cord-015021-pol2qm74	6253	27	of	of	IN
cord-015021-pol2qm74	6253	28	negative	negative	JJ
cord-015021-pol2qm74	6253	29	results	result	NNS
cord-015021-pol2qm74	6253	30	is	be	VBZ
cord-015021-pol2qm74	6253	31	that	that	IN
cord-015021-pol2qm74	6253	32	the	the	DT
cord-015021-pol2qm74	6253	33	studies	study	NNS
cord-015021-pol2qm74	6253	34	were	be	VBD
cord-015021-pol2qm74	6253	35	improperly	improperly	RB
cord-015021-pol2qm74	6253	36	designed	design	VBN
cord-015021-pol2qm74	6253	37	and	and	CC
cord-015021-pol2qm74	6253	38	thus	thus	RB
cord-015021-pol2qm74	6253	39	could	could	MD
cord-015021-pol2qm74	6253	40	not	not	RB
cord-015021-pol2qm74	6253	41	show	show	VB
cord-015021-pol2qm74	6253	42	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6253	43	benefit	benefit	NN
cord-015021-pol2qm74	6253	44	,	,	,
cord-015021-pol2qm74	6253	45	if	if	IN
cord-015021-pol2qm74	6253	46	it	-PRON-	PRP
cord-015021-pol2qm74	6253	47	existed	exist	VBD
cord-015021-pol2qm74	6253	48	.	.	.
cord-015021-pol2qm74	6254	1	Problems	problem	NNS
cord-015021-pol2qm74	6254	2	which	which	WDT
cord-015021-pol2qm74	6254	3	have	have	VBP
cord-015021-pol2qm74	6254	4	been	be	VBN
cord-015021-pol2qm74	6254	5	identified	identify	VBN
cord-015021-pol2qm74	6254	6	in	in	IN
cord-015021-pol2qm74	6254	7	these	these	DT
cord-015021-pol2qm74	6254	8	various	various	JJ
cord-015021-pol2qm74	6254	9	trials	trial	NNS
cord-015021-pol2qm74	6254	10	include	include	VBP
cord-015021-pol2qm74	6254	11	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	6254	12	or	or	CC
cord-015021-pol2qm74	6254	13	unrealistic	unrealistic	JJ
cord-015021-pol2qm74	6254	14	definitions	definition	NNS
cord-015021-pol2qm74	6254	15	of	of	IN
cord-015021-pol2qm74	6254	16	response	response	NN
cord-015021-pol2qm74	6254	17	to	to	IN
cord-015021-pol2qm74	6254	18	the	the	DT
cord-015021-pol2qm74	6254	19	drug	drug	NN
cord-015021-pol2qm74	6254	20	;	;	,
cord-015021-pol2qm74	6254	21	inadequate	inadequate	JJ
cord-015021-pol2qm74	6254	22	sample	sample	NN
cord-015021-pol2qm74	6254	23	size	size	NN
cord-015021-pol2qm74	6254	24	,	,	,
cord-015021-pol2qm74	6254	25	with	with	IN
cord-015021-pol2qm74	6254	26	attendant	attendant	JJ
cord-015021-pol2qm74	6254	27	insufficient	insufficient	JJ
cord-015021-pol2qm74	6254	28	statistical	statistical	JJ
cord-015021-pol2qm74	6254	29	power	power	NN
cord-015021-pol2qm74	6254	30	to	to	TO
cord-015021-pol2qm74	6254	31	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6254	32	a	a	DT
cord-015021-pol2qm74	6254	33	difference	difference	NN
cord-015021-pol2qm74	6254	34	,	,	,
cord-015021-pol2qm74	6254	35	if	if	IN
cord-015021-pol2qm74	6254	36	it	-PRON-	PRP
cord-015021-pol2qm74	6254	37	existed	exist	VBD
cord-015021-pol2qm74	6254	38	;	;	,
cord-015021-pol2qm74	6254	39	insufficient	insufficient	JJ
cord-015021-pol2qm74	6254	40	standardization	standardization	NN
cord-015021-pol2qm74	6254	41	of	of	IN
cord-015021-pol2qm74	6254	42	customary	customary	JJ
cord-015021-pol2qm74	6254	43	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6254	44	maneuvers	maneuver	NNS
cord-015021-pol2qm74	6254	45	in	in	IN
cord-015021-pol2qm74	6254	46	septic	septic	JJ
cord-015021-pol2qm74	6254	47	patients	patient	NNS
cord-015021-pol2qm74	6254	48	;	;	:
cord-015021-pol2qm74	6254	49	imprecise	imprecise	JJ
cord-015021-pol2qm74	6254	50	criteria	criterion	NNS
cord-015021-pol2qm74	6254	51	for	for	IN
cord-015021-pol2qm74	6254	52	patient	patient	JJ
cord-015021-pol2qm74	6254	53	entry	entry	NN
cord-015021-pol2qm74	6254	54	into	into	IN
cord-015021-pol2qm74	6254	55	the	the	DT
cord-015021-pol2qm74	6254	56	study	study	NN
cord-015021-pol2qm74	6254	57	,	,	,
cord-015021-pol2qm74	6254	58	which	which	WDT
cord-015021-pol2qm74	6254	59	creates	create	VBZ
cord-015021-pol2qm74	6254	60	unacceptable	unacceptable	JJ
cord-015021-pol2qm74	6254	61	inhomogeneity	inhomogeneity	NN
cord-015021-pol2qm74	6254	62	between	between	IN
cord-015021-pol2qm74	6254	63	control	control	NN
cord-015021-pol2qm74	6254	64	and	and	CC
cord-015021-pol2qm74	6254	65	treatment	treatment	NN
cord-015021-pol2qm74	6254	66	groups	group	NNS
cord-015021-pol2qm74	6254	67	and	and	CC
cord-015021-pol2qm74	6254	68	invites	invite	VBZ
cord-015021-pol2qm74	6254	69	unjustified	unjustified	JJ
cord-015021-pol2qm74	6254	70	post	post	JJ
cord-015021-pol2qm74	6254	71	-	-	JJ
cord-015021-pol2qm74	6254	72	study	study	JJ
cord-015021-pol2qm74	6254	73	subgroup	subgroup	NN
cord-015021-pol2qm74	6254	74	analysis	analysis	NN
cord-015021-pol2qm74	6254	75	;	;	:
cord-015021-pol2qm74	6254	76	the	the	DT
cord-015021-pol2qm74	6254	77	lack	lack	NN
cord-015021-pol2qm74	6254	78	of	of	IN
cord-015021-pol2qm74	6254	79	a	a	DT
cord-015021-pol2qm74	6254	80	formal	formal	JJ
cord-015021-pol2qm74	6254	81	sequential	sequential	JJ
cord-015021-pol2qm74	6254	82	monitoring	monitoring	NN
cord-015021-pol2qm74	6254	83	procedure	procedure	NN
cord-015021-pol2qm74	6254	84	for	for	IN
cord-015021-pol2qm74	6254	85	interim	interim	JJ
cord-015021-pol2qm74	6254	86	data	datum	NNS
cord-015021-pol2qm74	6254	87	analysis	analysis	NN
cord-015021-pol2qm74	6254	88	,	,	,
cord-015021-pol2qm74	6254	89	which	which	WDT
cord-015021-pol2qm74	6254	90	could	could	MD
cord-015021-pol2qm74	6254	91	potentially	potentially	RB
cord-015021-pol2qm74	6254	92	affect	affect	VB
cord-015021-pol2qm74	6254	93	patient	patient	JJ
cord-015021-pol2qm74	6254	94	safety	safety	NN
cord-015021-pol2qm74	6254	95	;	;	:
cord-015021-pol2qm74	6254	96	and	and	CC
cord-015021-pol2qm74	6254	97	a	a	DT
cord-015021-pol2qm74	6254	98	primary	primary	JJ
cord-015021-pol2qm74	6254	99	analysis	analysis	NN
cord-015021-pol2qm74	6254	100	of	of	IN
cord-015021-pol2qm74	6254	101	study	study	NN
cord-015021-pol2qm74	6254	102	results	result	NNS
cord-015021-pol2qm74	6254	103	that	that	WDT
cord-015021-pol2qm74	6254	104	excludes	exclude	VBZ
cord-015021-pol2qm74	6254	105	protocol	protocol	NN
cord-015021-pol2qm74	6254	106	deviants	deviant	NNS
cord-015021-pol2qm74	6254	107	and	and	CC
cord-015021-pol2qm74	6254	108	is	be	VBZ
cord-015021-pol2qm74	6254	109	not	not	RB
cord-015021-pol2qm74	6254	110	according	accord	VBG
cord-015021-pol2qm74	6254	111	to	to	IN
cord-015021-pol2qm74	6254	112	intent	intent	NN
cord-015021-pol2qm74	6254	113	-	-	HYPH
cord-015021-pol2qm74	6254	114	to	to	IN
cord-015021-pol2qm74	6254	115	-	-	HYPH
cord-015021-pol2qm74	6254	116	treat	treat	NN
cord-015021-pol2qm74	6254	117	.	.	.
cord-015021-pol2qm74	6255	1	These	these	DT
cord-015021-pol2qm74	6255	2	and	and	CC
cord-015021-pol2qm74	6255	3	other	other	JJ
cord-015021-pol2qm74	6255	4	problems	problem	NNS
cord-015021-pol2qm74	6255	5	have	have	VBP
cord-015021-pol2qm74	6255	6	impacted	impact	VBN
cord-015021-pol2qm74	6255	7	upon	upon	IN
cord-015021-pol2qm74	6255	8	the	the	DT
cord-015021-pol2qm74	6255	9	validity	validity	NN
cord-015021-pol2qm74	6255	10	of	of	IN
cord-015021-pol2qm74	6255	11	the	the	DT
cord-015021-pol2qm74	6255	12	various	various	JJ
cord-015021-pol2qm74	6255	13	trials	trial	NNS
cord-015021-pol2qm74	6255	14	conducted	conduct	VBN
cord-015021-pol2qm74	6255	15	to	to	IN
cord-015021-pol2qm74	6255	16	date	date	NN
cord-015021-pol2qm74	6255	17	and	and	CC
cord-015021-pol2qm74	6255	18	may	may	MD
cord-015021-pol2qm74	6255	19	well	well	RB
cord-015021-pol2qm74	6255	20	have	have	VB
cord-015021-pol2qm74	6255	21	prevented	prevent	VBN
cord-015021-pol2qm74	6255	22	the	the	DT
cord-015021-pol2qm74	6255	23	resolution	resolution	NN
cord-015021-pol2qm74	6255	24	of	of	IN
cord-015021-pol2qm74	6255	25	controversies	controversy	NNS
cord-015021-pol2qm74	6255	26	surrounding	surround	VBG
cord-015021-pol2qm74	6255	27	the	the	DT
cord-015021-pol2qm74	6255	28	use	use	NN
cord-015021-pol2qm74	6255	29	of	of	IN
cord-015021-pol2qm74	6255	30	certain	certain	JJ
cord-015021-pol2qm74	6255	31	agents	agent	NNS
cord-015021-pol2qm74	6255	32	in	in	IN
cord-015021-pol2qm74	6255	33	the	the	DT
cord-015021-pol2qm74	6255	34	treatment	treatment	NN
cord-015021-pol2qm74	6255	35	of	of	IN
cord-015021-pol2qm74	6255	36	septic	septic	JJ
cord-015021-pol2qm74	6255	37	patients	patient	NNS
cord-015021-pol2qm74	6255	38	.	.	.
cord-015021-pol2qm74	6256	1	The	the	DT
cord-015021-pol2qm74	6256	2	complexity	complexity	NN
cord-015021-pol2qm74	6256	3	of	of	IN
cord-015021-pol2qm74	6256	4	bacterially	bacterially	RB
cord-015021-pol2qm74	6256	5	-	-	HYPH
cord-015021-pol2qm74	6256	6	induced	induce	VBN
cord-015021-pol2qm74	6256	7	septic	septic	JJ
cord-015021-pol2qm74	6256	8	shock	shock	NN
cord-015021-pol2qm74	6256	9	involves	involve	VBZ
cord-015021-pol2qm74	6256	10	a	a	DT
cord-015021-pol2qm74	6256	11	cascade	cascade	NN
cord-015021-pol2qm74	6256	12	of	of	IN
cord-015021-pol2qm74	6256	13	events	event	NNS
cord-015021-pol2qm74	6256	14	that	that	WDT
cord-015021-pol2qm74	6256	15	evolve	evolve	VBP
cord-015021-pol2qm74	6256	16	over	over	IN
cord-015021-pol2qm74	6256	17	time	time	NN
cord-015021-pol2qm74	6256	18	,	,	,
cord-015021-pol2qm74	6256	19	beginning	begin	VBG
cord-015021-pol2qm74	6256	20	with	with	IN
cord-015021-pol2qm74	6256	21	the	the	DT
cord-015021-pol2qm74	6256	22	proliferation	proliferation	NN
cord-015021-pol2qm74	6256	23	of	of	IN
cord-015021-pol2qm74	6256	24	offending	offend	VBG
cord-015021-pol2qm74	6256	25	organisms	organism	NNS
cord-015021-pol2qm74	6256	26	and	and	CC
cord-015021-pol2qm74	6256	27	followed	follow	VBN
cord-015021-pol2qm74	6256	28	by	by	IN
cord-015021-pol2qm74	6256	29	the	the	DT
cord-015021-pol2qm74	6256	30	release	release	NN
cord-015021-pol2qm74	6256	31	of	of	IN
cord-015021-pol2qm74	6256	32	toxic	toxic	JJ
cord-015021-pol2qm74	6256	33	mediators	mediator	NNS
cord-015021-pol2qm74	6256	34	from	from	IN
cord-015021-pol2qm74	6256	35	the	the	DT
cord-015021-pol2qm74	6256	36	bacteria	bacteria	NNS
cord-015021-pol2qm74	6256	37	.	.	.
cord-015021-pol2qm74	6257	1	Endotoxins	endotoxin	NNS
cord-015021-pol2qm74	6257	2	[	[	-LRB-
cord-015021-pol2qm74	6257	3	e.g.	e.g.	RB
cord-015021-pol2qm74	6257	4	lipopolysaccharides	lipopolysaccharides	NNP
cord-015021-pol2qm74	6257	5	)	)	-RRB-
cord-015021-pol2qm74	6257	6	from	from	IN
cord-015021-pol2qm74	6257	7	gram	gram	NN
cord-015021-pol2qm74	6257	8	-	-	HYPH
cord-015021-pol2qm74	6257	9	negative	negative	JJ
cord-015021-pol2qm74	6257	10	bacteria	bacteria	NNS
cord-015021-pol2qm74	6257	11	initiate	initiate	VBP
cord-015021-pol2qm74	6257	12	septic	septic	JJ
cord-015021-pol2qm74	6257	13	shock	shock	NN
cord-015021-pol2qm74	6257	14	by	by	IN
cord-015021-pol2qm74	6257	15	precipitating	precipitate	VBG
cord-015021-pol2qm74	6257	16	a	a	DT
cord-015021-pol2qm74	6257	17	systemic	systemic	JJ
cord-015021-pol2qm74	6257	18	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6257	19	response	response	NN
cord-015021-pol2qm74	6257	20	syndrome	syndrome	NN
cord-015021-pol2qm74	6257	21	(	(	-LRB-
cord-015021-pol2qm74	6257	22	SIRS	sirs	UH
cord-015021-pol2qm74	6257	23	)	)	-RRB-
cord-015021-pol2qm74	6257	24	through	through	IN
cord-015021-pol2qm74	6257	25	release	release	NN
cord-015021-pol2qm74	6257	26	of	of	IN
cord-015021-pol2qm74	6257	27	a	a	DT
cord-015021-pol2qm74	6257	28	broad	broad	JJ
cord-015021-pol2qm74	6257	29	spectrum	spectrum	NN
cord-015021-pol2qm74	6257	30	of	of	IN
cord-015021-pol2qm74	6257	31	hostderived	hostderived	JJ
cord-015021-pol2qm74	6257	32	mediators	mediator	NNS
cord-015021-pol2qm74	6257	33	.	.	.
cord-015021-pol2qm74	6258	1	Over	over	IN
cord-015021-pol2qm74	6258	2	the	the	DT
cord-015021-pol2qm74	6258	3	last	last	JJ
cord-015021-pol2qm74	6258	4	century	century	NN
cord-015021-pol2qm74	6258	5	,	,	,
cord-015021-pol2qm74	6258	6	hundreds	hundred	NNS
cord-015021-pol2qm74	6258	7	of	of	IN
cord-015021-pol2qm74	6258	8	these	these	DT
cord-015021-pol2qm74	6258	9	endogenous	endogenous	JJ
cord-015021-pol2qm74	6258	10	mediators	mediator	NNS
cord-015021-pol2qm74	6258	11	have	have	VBP
cord-015021-pol2qm74	6258	12	been	be	VBN
cord-015021-pol2qm74	6258	13	proposed	propose	VBN
cord-015021-pol2qm74	6258	14	to	to	TO
cord-015021-pol2qm74	6258	15	serve	serve	VB
cord-015021-pol2qm74	6258	16	as	as	IN
cord-015021-pol2qm74	6258	17	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	6258	18	substances	substance	NNS
cord-015021-pol2qm74	6258	19	in	in	IN
cord-015021-pol2qm74	6258	20	this	this	DT
cord-015021-pol2qm74	6258	21	"	"	``
cord-015021-pol2qm74	6258	22	alphabet	alphabet	NN
cord-015021-pol2qm74	6258	23	soup	soup	NN
cord-015021-pol2qm74	6258	24	"	"	''
cord-015021-pol2qm74	6258	25	of	of	IN
cord-015021-pol2qm74	6258	26	cytokines	cytokine	NNS
cord-015021-pol2qm74	6258	27	,	,	,
cord-015021-pol2qm74	6258	28	eieosanoids	eieosanoid	NNS
cord-015021-pol2qm74	6258	29	,	,	,
cord-015021-pol2qm74	6258	30	biogenic	biogenic	JJ
cord-015021-pol2qm74	6258	31	amines	amine	NNS
cord-015021-pol2qm74	6258	32	,	,	,
cord-015021-pol2qm74	6258	33	kinins	kinin	NNS
cord-015021-pol2qm74	6258	34	,	,	,
cord-015021-pol2qm74	6258	35	peptides	peptide	NNS
cord-015021-pol2qm74	6258	36	,	,	,
cord-015021-pol2qm74	6258	37	ions	ion	NNS
cord-015021-pol2qm74	6258	38	and	and	CC
cord-015021-pol2qm74	6258	39	hormones	hormone	NNS
cord-015021-pol2qm74	6258	40	.	.	.
cord-015021-pol2qm74	6259	1	An	an	DT
cord-015021-pol2qm74	6259	2	evaluation	evaluation	NN
cord-015021-pol2qm74	6259	3	of	of	IN
cord-015021-pol2qm74	6259	4	the	the	DT
cord-015021-pol2qm74	6259	5	literature	literature	NN
cord-015021-pol2qm74	6259	6	on	on	IN
cord-015021-pol2qm74	6259	7	septic	septic	JJ
cord-015021-pol2qm74	6259	8	shock	shock	NN
cord-015021-pol2qm74	6259	9	leaves	leave	VBZ
cord-015021-pol2qm74	6259	10	the	the	DT
cord-015021-pol2qm74	6259	11	investigator	investigator	NN
cord-015021-pol2qm74	6259	12	with	with	IN
cord-015021-pol2qm74	6259	13	a	a	DT
cord-015021-pol2qm74	6259	14	sense	sense	NN
cord-015021-pol2qm74	6259	15	that	that	IN
cord-015021-pol2qm74	6259	16	,	,	,
cord-015021-pol2qm74	6259	17	although	although	IN
cord-015021-pol2qm74	6259	18	many	many	JJ
cord-015021-pol2qm74	6259	19	pieces	piece	NNS
cord-015021-pol2qm74	6259	20	of	of	IN
cord-015021-pol2qm74	6259	21	the	the	DT
cord-015021-pol2qm74	6259	22	septic	septic	JJ
cord-015021-pol2qm74	6259	23	shock	shock	NN
cord-015021-pol2qm74	6259	24	puzzle	puzzle	NN
cord-015021-pol2qm74	6259	25	have	have	VBP
cord-015021-pol2qm74	6259	26	been	be	VBN
cord-015021-pol2qm74	6259	27	presented	present	VBN
cord-015021-pol2qm74	6259	28	,	,	,
cord-015021-pol2qm74	6259	29	no	no	DT
cord-015021-pol2qm74	6259	30	clue	clue	NN
cord-015021-pol2qm74	6259	31	was	be	VBD
cord-015021-pol2qm74	6259	32	provided	provide	VBN
cord-015021-pol2qm74	6259	33	to	to	TO
cord-015021-pol2qm74	6259	34	indicate	indicate	VB
cord-015021-pol2qm74	6259	35	how	how	WRB
cord-015021-pol2qm74	6259	36	these	these	DT
cord-015021-pol2qm74	6259	37	pieces	piece	NNS
cord-015021-pol2qm74	6259	38	fit	fit	VBP
cord-015021-pol2qm74	6259	39	together	together	RB
cord-015021-pol2qm74	6259	40	,	,	.
cord-015021-pol2qm74	6260	1	In	in	IN
cord-015021-pol2qm74	6260	2	an	an	DT
cord-015021-pol2qm74	6260	3	attempt	attempt	NN
cord-015021-pol2qm74	6260	4	to	to	TO
cord-015021-pol2qm74	6260	5	assess	assess	VB
cord-015021-pol2qm74	6260	6	objectively	objectively	RB
cord-015021-pol2qm74	6260	7	the	the	DT
cord-015021-pol2qm74	6260	8	causal	causal	JJ
cord-015021-pol2qm74	6260	9	role	role	NN
cord-015021-pol2qm74	6260	10	of	of	IN
cord-015021-pol2qm74	6260	11	individual	individual	JJ
cord-015021-pol2qm74	6260	12	mediators	mediator	NNS
cord-015021-pol2qm74	6260	13	,	,	,
cord-015021-pol2qm74	6260	14	we	-PRON-	PRP
cord-015021-pol2qm74	6260	15	recently	recently	RB
cord-015021-pol2qm74	6260	16	completed	complete	VBD
cord-015021-pol2qm74	6260	17	a	a	DT
cord-015021-pol2qm74	6260	18	collective	collective	JJ
cord-015021-pol2qm74	6260	19	meta	meta	NN
cord-015021-pol2qm74	6260	20	-	-	HYPH
cord-015021-pol2qm74	6260	21	analysis	analysis	NN
cord-015021-pol2qm74	6260	22	of	of	IN
cord-015021-pol2qm74	6260	23	24	24	CD
cord-015021-pol2qm74	6260	24	mediators	mediator	NNS
cord-015021-pol2qm74	6260	25	that	that	WDT
cord-015021-pol2qm74	6260	26	were	be	VBD
cord-015021-pol2qm74	6260	27	individually	individually	RB
cord-015021-pol2qm74	6260	28	reviewed	review	VBN
cord-015021-pol2qm74	6260	29	and	and	CC
cord-015021-pol2qm74	6260	30	subjected	subject	VBN
cord-015021-pol2qm74	6260	31	to	to	IN
cord-015021-pol2qm74	6260	32	Koch	Koch	NNP
cord-015021-pol2qm74	6260	33	-	-	HYPH
cord-015021-pol2qm74	6260	34	Dale	Dale	NNP
cord-015021-pol2qm74	6260	35	analysis	analysis	NN
cord-015021-pol2qm74	6260	36	of	of	IN
cord-015021-pol2qm74	6260	37	causality	causality	NN
cord-015021-pol2qm74	6260	38	by	by	IN
cord-015021-pol2qm74	6260	39	distinguished	distinguished	JJ
cord-015021-pol2qm74	6260	40	authorities	authority	NNS
cord-015021-pol2qm74	6260	41	in	in	IN
cord-015021-pol2qm74	6260	42	the	the	DT
cord-015021-pol2qm74	6260	43	field	field	NN
cord-015021-pol2qm74	6260	44	(	(	-LRB-
cord-015021-pol2qm74	6260	45	1	1	CD
cord-015021-pol2qm74	6260	46	)	)	-RRB-
cord-015021-pol2qm74	6260	47	.	.	.
cord-015021-pol2qm74	6261	1	In	in	IN
cord-015021-pol2qm74	6261	2	summary	summary	NN
cord-015021-pol2qm74	6261	3	,	,	,
cord-015021-pol2qm74	6261	4	our	-PRON-	PRP$
cord-015021-pol2qm74	6261	5	attempt	attempt	NN
cord-015021-pol2qm74	6261	6	analyze	analyze	VB
cord-015021-pol2qm74	6261	7	available	available	JJ
cord-015021-pol2qm74	6261	8	evidence	evidence	NN
cord-015021-pol2qm74	6261	9	to	to	TO
cord-015021-pol2qm74	6261	10	support	support	VB
cord-015021-pol2qm74	6261	11	a	a	DT
cord-015021-pol2qm74	6261	12	cause	cause	NN
cord-015021-pol2qm74	6261	13	-	-	HYPH
cord-015021-pol2qm74	6261	14	and	and	CC
cord-015021-pol2qm74	6261	15	-	-	HYPH
cord-015021-pol2qm74	6261	16	effect	effect	NN
cord-015021-pol2qm74	6261	17	relationship	relationship	NN
cord-015021-pol2qm74	6261	18	for	for	IN
cord-015021-pol2qm74	6261	19	putative	putative	JJ
cord-015021-pol2qm74	6261	20	mediators	mediator	NNS
cord-015021-pol2qm74	6261	21	of	of	IN
cord-015021-pol2qm74	6261	22	septic	septic	JJ
cord-015021-pol2qm74	6261	23	shock	shock	NN
cord-015021-pol2qm74	6261	24	revealed	reveal	VBD
cord-015021-pol2qm74	6261	25	that	that	IN
cord-015021-pol2qm74	6261	26	only	only	RB
cord-015021-pol2qm74	6261	27	eight	eight	CD
cord-015021-pol2qm74	6261	28	of	of	IN
cord-015021-pol2qm74	6261	29	the	the	DT
cord-015021-pol2qm74	6261	30	24	24	CD
cord-015021-pol2qm74	6261	31	mediators	mediator	NNS
cord-015021-pol2qm74	6261	32	analyzed	analyze	VBN
cord-015021-pol2qm74	6261	33	could	could	MD
cord-015021-pol2qm74	6261	34	be	be	VB
cord-015021-pol2qm74	6261	35	strongly	strongly	RB
cord-015021-pol2qm74	6261	36	inferred	infer	VBN
cord-015021-pol2qm74	6261	37	as	as	IN
cord-015021-pol2qm74	6261	38	playing	play	VBG
cord-015021-pol2qm74	6261	39	a	a	DT
cord-015021-pol2qm74	6261	40	causal	causal	JJ
cord-015021-pol2qm74	6261	41	role	role	NN
cord-015021-pol2qm74	6261	42	in	in	IN
cord-015021-pol2qm74	6261	43	septic	septic	JJ
cord-015021-pol2qm74	6261	44	shock	shock	NN
cord-015021-pol2qm74	6261	45	.	.	.
cord-015021-pol2qm74	6262	1	Evidence	evidence	NN
cord-015021-pol2qm74	6262	2	supported	support	VBD
cord-015021-pol2qm74	6262	3	the	the	DT
cord-015021-pol2qm74	6262	4	involvement	involvement	NN
cord-015021-pol2qm74	6262	5	of	of	IN
cord-015021-pol2qm74	6262	6	endotoxln	endotoxln	NNP
cord-015021-pol2qm74	6262	7	,	,	,
cord-015021-pol2qm74	6262	8	endorphins	endorphin	NNS
cord-015021-pol2qm74	6262	9	,	,	,
cord-015021-pol2qm74	6262	10	complement	complement	NN
cord-015021-pol2qm74	6262	11	,	,	,
cord-015021-pol2qm74	6262	12	interleukins	interleukin	NNS
cord-015021-pol2qm74	6262	13	,	,	,
cord-015021-pol2qm74	6262	14	tumor	tumor	NN
cord-015021-pol2qm74	6262	15	necrosis	necrosis	NN
cord-015021-pol2qm74	6262	16	factor	factor	NN
cord-015021-pol2qm74	6262	17	,	,	,
cord-015021-pol2qm74	6262	18	eieosanoids	eieosanoid	NNS
cord-015021-pol2qm74	6262	19	,	,	,
cord-015021-pol2qm74	6262	20	platelet	platelet	NN
cord-015021-pol2qm74	6262	21	activating	activate	VBG
cord-015021-pol2qm74	6262	22	factor	factor	NN
cord-015021-pol2qm74	6262	23	and	and	CC
cord-015021-pol2qm74	6262	24	calcium	calcium	NN
cord-015021-pol2qm74	6262	25	.	.	.
cord-015021-pol2qm74	6263	1	Other	other	JJ
cord-015021-pol2qm74	6263	2	mediators	mediator	NNS
cord-015021-pol2qm74	6263	3	either	either	CC
cord-015021-pol2qm74	6263	4	lacked	lack	VBD
cord-015021-pol2qm74	6263	5	adequate	adequate	JJ
cord-015021-pol2qm74	6263	6	supportive	supportive	JJ
cord-015021-pol2qm74	6263	7	evidence	evidence	NN
cord-015021-pol2qm74	6263	8	or	or	CC
cord-015021-pol2qm74	6263	9	were	be	VBD
cord-015021-pol2qm74	6263	10	not	not	RB
cord-015021-pol2qm74	6263	11	conclusively	conclusively	RB
cord-015021-pol2qm74	6263	12	involved	involve	VBN
cord-015021-pol2qm74	6263	13	.	.	.
cord-015021-pol2qm74	6264	1	Posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	6264	2	outcome	outcome	NN
cord-015021-pol2qm74	6264	3	may	may	MD
cord-015021-pol2qm74	6264	4	be	be	VB
cord-015021-pol2qm74	6264	5	reduced	reduce	VBN
cord-015021-pol2qm74	6264	6	by	by	IN
cord-015021-pol2qm74	6264	7	an	an	DT
cord-015021-pol2qm74	6264	8	amplified	amplify	VBN
cord-015021-pol2qm74	6264	9	stress	stress	NN
cord-015021-pol2qm74	6264	10	response	response	NN
cord-015021-pol2qm74	6264	11	mediated	mediate	VBN
cord-015021-pol2qm74	6264	12	by	by	IN
cord-015021-pol2qm74	6264	13	neural	neural	JJ
cord-015021-pol2qm74	6264	14	and	and	CC
cord-015021-pol2qm74	6264	15	humoral	humoral	JJ
cord-015021-pol2qm74	6264	16	stimuli	stimulus	NNS
cord-015021-pol2qm74	6264	17	.	.	.
cord-015021-pol2qm74	6265	1	The	the	DT
cord-015021-pol2qm74	6265	2	classical	classical	JJ
cord-015021-pol2qm74	6265	3	hormonal	hormonal	JJ
cord-015021-pol2qm74	6265	4	catabolic	catabolic	JJ
cord-015021-pol2qm74	6265	5	response	response	NN
cord-015021-pol2qm74	6265	6	is	be	VBZ
cord-015021-pol2qm74	6265	7	predominantly	predominantly	RB
cord-015021-pol2qm74	6265	8	mediated	mediate	VBN
cord-015021-pol2qm74	6265	9	directly	directly	RB
cord-015021-pol2qm74	6265	10	or	or	CC
cord-015021-pol2qm74	6265	11	indirectly	indirectly	RB
cord-015021-pol2qm74	6265	12	by	by	IN
cord-015021-pol2qm74	6265	13	neural	neural	JJ
cord-015021-pol2qm74	6265	14	stimuli	stimulus	NNS
cord-015021-pol2qm74	6265	15	,	,	,
cord-015021-pol2qm74	6265	16	while	while	IN
cord-015021-pol2qm74	6265	17	most	most	JJS
cord-015021-pol2qm74	6265	18	changes	change	NNS
cord-015021-pol2qm74	6265	19	in	in	IN
cord-015021-pol2qm74	6265	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6265	21	responses	response	NNS
cord-015021-pol2qm74	6265	22	such	such	JJ
cord-015021-pol2qm74	6265	23	as	as	IN
cord-015021-pol2qm74	6265	24	leukocytosis	leukocytosis	NNP
cord-015021-pol2qm74	6265	25	,	,	,
cord-015021-pol2qm74	6265	26	acute	acute	JJ
cord-015021-pol2qm74	6265	27	phase	phase	NN
cord-015021-pol2qm74	6265	28	proteins	protein	NNS
cord-015021-pol2qm74	6265	29	and	and	CC
cord-015021-pol2qm74	6265	30	changes	change	NNS
cord-015021-pol2qm74	6265	31	immunofunction	immunofunction	NN
cord-015021-pol2qm74	6265	32	are	be	VBP
cord-015021-pol2qm74	6265	33	mediated	mediate	VBN
cord-015021-pol2qm74	6265	34	by	by	IN
cord-015021-pol2qm74	6265	35	humoral	humoral	JJ
cord-015021-pol2qm74	6265	36	mediators	mediator	NNS
cord-015021-pol2qm74	6265	37	.	.	.
cord-015021-pol2qm74	6266	1	Clinical	clinical	JJ
cord-015021-pol2qm74	6266	2	experience	experience	NN
cord-015021-pol2qm74	6266	3	from	from	IN
cord-015021-pol2qm74	6266	4	controlled	control	VBN
cord-015021-pol2qm74	6266	5	studies	study	NNS
cord-015021-pol2qm74	6266	6	suggest	suggest	VBP
cord-015021-pol2qm74	6266	7	afferent	afferent	JJ
cord-015021-pol2qm74	6266	8	neural	neural	JJ
cord-015021-pol2qm74	6266	9	blockade	blockade	NN
cord-015021-pol2qm74	6266	10	and	and	CC
cord-015021-pol2qm74	6266	11	modification	modification	NN
cord-015021-pol2qm74	6266	12	of	of	IN
cord-015021-pol2qm74	6266	13	stress	stress	NN
cord-015021-pol2qm74	6266	14	response	response	NN
cord-015021-pol2qm74	6266	15	to	to	TO
cord-015021-pol2qm74	6266	16	improve	improve	VB
cord-015021-pol2qm74	6266	17	organ	organ	NN
cord-015021-pol2qm74	6266	18	function	function	NN
cord-015021-pol2qm74	6266	19	and	and	CC
cord-015021-pol2qm74	6266	20	postoperative	postoperative	JJ
cord-015021-pol2qm74	6266	21	outcome	outcome	NN
cord-015021-pol2qm74	6266	22	,	,	,
cord-015021-pol2qm74	6266	23	and	and	CC
cord-015021-pol2qm74	6266	24	limited	limited	JJ
cord-015021-pol2qm74	6266	25	experimental	experimental	JJ
cord-015021-pol2qm74	6266	26	studies	study	NNS
cord-015021-pol2qm74	6266	27	also	also	RB
cord-015021-pol2qm74	6266	28	suggest	suggest	VBP
cord-015021-pol2qm74	6266	29	neural	neural	JJ
cord-015021-pol2qm74	6266	30	blockade	blockade	NN
cord-015021-pol2qm74	6266	31	to	to	TO
cord-015021-pol2qm74	6266	32	be	be	VB
cord-015021-pol2qm74	6266	33	of	of	IN
cord-015021-pol2qm74	6266	34	beneficial	beneficial	JJ
cord-015021-pol2qm74	6266	35	value	value	NN
cord-015021-pol2qm74	6266	36	in	in	IN
cord-015021-pol2qm74	6266	37	shock	shock	NN
cord-015021-pol2qm74	6266	38	states	state	NNS
cord-015021-pol2qm74	6266	39	.	.	.
cord-015021-pol2qm74	6267	1	Of	of	IN
cord-015021-pol2qm74	6267	2	special	special	JJ
cord-015021-pol2qm74	6267	3	value	value	NN
cord-015021-pol2qm74	6267	4	may	may	MD
cord-015021-pol2qm74	6267	5	be	be	VB
cord-015021-pol2qm74	6267	6	the	the	DT
cord-015021-pol2qm74	6267	7	improved	improve	VBN
cord-015021-pol2qm74	6267	8	gastro	gastro	JJ
cord-015021-pol2qm74	6267	9	-	-	JJ
cord-015021-pol2qm74	6267	10	intestinal	intestinal	JJ
cord-015021-pol2qm74	6267	11	motility	motility	NN
cord-015021-pol2qm74	6267	12	after	after	IN
cord-015021-pol2qm74	6267	13	neural	neural	JJ
cord-015021-pol2qm74	6267	14	(	(	-LRB-
cord-015021-pol2qm74	6267	15	visceral	visceral	JJ
cord-015021-pol2qm74	6267	16	)	)	-RRB-
cord-015021-pol2qm74	6267	17	blockade	blockade	NN
cord-015021-pol2qm74	6267	18	.	.	.
cord-015021-pol2qm74	6268	1	No	no	DT
cord-015021-pol2qm74	6268	2	outcome	outcome	NN
cord-015021-pol2qm74	6268	3	studies	study	NNS
cord-015021-pol2qm74	6268	4	are	be	VBP
cord-015021-pol2qm74	6268	5	available	available	JJ
cord-015021-pol2qm74	6268	6	from	from	IN
cord-015021-pol2qm74	6268	7	patients	patient	NNS
cord-015021-pol2qm74	6268	8	with	with	IN
cord-015021-pol2qm74	6268	9	major	major	JJ
cord-015021-pol2qm74	6268	10	truma	truma	NNP
cord-015021-pol2qm74	6268	11	,	,	,
cord-015021-pol2qm74	6268	12	multiple	multiple	JJ
cord-015021-pol2qm74	6268	13	organ	organ	NN
cord-015021-pol2qm74	6268	14	failure	failure	NN
cord-015021-pol2qm74	6268	15	or	or	CC
cord-015021-pol2qm74	6268	16	sepsis	sepsis	NN
cord-015021-pol2qm74	6268	17	,	,	,
cord-015021-pol2qm74	6268	18	conditions	condition	NNS
cord-015021-pol2qm74	6268	19	where	where	WRB
cord-015021-pol2qm74	6268	20	humorai	humorai	NNP
cord-015021-pol2qm74	6268	21	mediators	mediator	NNS
cord-015021-pol2qm74	6268	22	may	may	MD
cord-015021-pol2qm74	6268	23	be	be	VB
cord-015021-pol2qm74	6268	24	more	more	RBR
cord-015021-pol2qm74	6268	25	important	important	JJ
cord-015021-pol2qm74	6268	26	to	to	TO
cord-015021-pol2qm74	6268	27	modify	modify	VB
cord-015021-pol2qm74	6268	28	than	than	IN
cord-015021-pol2qm74	6268	29	neurally	neurally	RB
cord-015021-pol2qm74	6268	30	mediated	mediate	VBN
cord-015021-pol2qm74	6268	31	responses	response	NNS
cord-015021-pol2qm74	6268	32	.	.	.
cord-015021-pol2qm74	6269	1	Future	future	JJ
cord-015021-pol2qm74	6269	2	studies	study	NNS
cord-015021-pol2qm74	6269	3	should	should	MD
cord-015021-pol2qm74	6269	4	investigate	investigate	VB
cord-015021-pol2qm74	6269	5	the	the	DT
cord-015021-pol2qm74	6269	6	clinical	clinical	JJ
cord-015021-pol2qm74	6269	7	outcome	outcome	NN
cord-015021-pol2qm74	6269	8	effect	effect	NN
cord-015021-pol2qm74	6269	9	of	of	IN
cord-015021-pol2qm74	6269	10	combined	combine	VBN
cord-015021-pol2qm74	6269	11	neural	neural	JJ
cord-015021-pol2qm74	6269	12	and	and	CC
cord-015021-pol2qm74	6269	13	humoral	humoral	JJ
cord-015021-pol2qm74	6269	14	mediated	mediate	VBN
cord-015021-pol2qm74	6269	15	blockade	blockade	NN
cord-015021-pol2qm74	6269	16	,	,	,
cord-015021-pol2qm74	6269	17	as	as	RB
cord-015021-pol2qm74	6269	18	well	well	RB
cord-015021-pol2qm74	6269	19	as	as	IN
cord-015021-pol2qm74	6269	20	the	the	DT
cord-015021-pol2qm74	6269	21	potential	potential	JJ
cord-015021-pol2qm74	6269	22	role	role	NN
cord-015021-pol2qm74	6269	23	of	of	IN
cord-015021-pol2qm74	6269	24	an	an	DT
cord-015021-pol2qm74	6269	25	initial	initial	JJ
cord-015021-pol2qm74	6269	26	neural	neural	JJ
cord-015021-pol2qm74	6269	27	blockade	blockade	NN
cord-015021-pol2qm74	6269	28	in	in	IN
cord-015021-pol2qm74	6269	29	elective	elective	JJ
cord-015021-pol2qm74	6269	30	trauma	trauma	NN
cord-015021-pol2qm74	6269	31	(	(	-LRB-
cord-015021-pol2qm74	6269	32	first	first	RB
cord-015021-pol2qm74	6269	33	hit	hit	VBN
cord-015021-pol2qm74	6269	34	)	)	-RRB-
cord-015021-pol2qm74	6269	35	to	to	TO
cord-015021-pol2qm74	6269	36	improve	improve	VB
cord-015021-pol2qm74	6269	37	the	the	DT
cord-015021-pol2qm74	6269	38	metabolic	metabolic	JJ
cord-015021-pol2qm74	6269	39	scene	scene	NN
cord-015021-pol2qm74	6269	40	and	and	CC
cord-015021-pol2qm74	6269	41	outcome	outcome	NN
cord-015021-pol2qm74	6269	42	if	if	IN
cord-015021-pol2qm74	6269	43	a	a	DT
cord-015021-pol2qm74	6269	44	postoperative	postoperative	JJ
cord-015021-pol2qm74	6269	45	complication	complication	NN
cord-015021-pol2qm74	6269	46	(	(	-LRB-
cord-015021-pol2qm74	6269	47	second	second	RB
cord-015021-pol2qm74	6269	48	hit	hit	NN
cord-015021-pol2qm74	6269	49	)	)	-RRB-
cord-015021-pol2qm74	6269	50	should	should	MD
cord-015021-pol2qm74	6269	51	occur	occur	VB
cord-015021-pol2qm74	6269	52	.	.	.
cord-015021-pol2qm74	6270	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	6270	2	elastase	elastase	NN
cord-015021-pol2qm74	6270	3	is	be	VBZ
cord-015021-pol2qm74	6270	4	the	the	DT
cord-015021-pol2qm74	6270	5	predominant	predominant	JJ
cord-015021-pol2qm74	6270	6	protease	protease	NN
cord-015021-pol2qm74	6270	7	of	of	IN
cord-015021-pol2qm74	6270	8	the	the	DT
cord-015021-pol2qm74	6270	9	human	human	JJ
cord-015021-pol2qm74	6270	10	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6270	11	.	.	.
cord-015021-pol2qm74	6271	1	This	this	DT
cord-015021-pol2qm74	6271	2	enzyme	enzyme	NN
cord-015021-pol2qm74	6271	3	,	,	,
cord-015021-pol2qm74	6271	4	and	and	CC
cord-015021-pol2qm74	6271	5	a	a	DT
cord-015021-pol2qm74	6271	6	variety	variety	NN
cord-015021-pol2qm74	6271	7	of	of	IN
cord-015021-pol2qm74	6271	8	other	other	JJ
cord-015021-pol2qm74	6271	9	enzymes	enzyme	NNS
cord-015021-pol2qm74	6271	10	,	,	,
cord-015021-pol2qm74	6271	11	including	include	VBG
cord-015021-pol2qm74	6271	12	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6271	13	collagenase	collagenase	NNP
cord-015021-pol2qm74	6271	14	,	,	,
cord-015021-pol2qm74	6271	15	are	be	VBP
cord-015021-pol2qm74	6271	16	released	release	VBN
cord-015021-pol2qm74	6271	17	by	by	IN
cord-015021-pol2qm74	6271	18	activated	activate	VBN
cord-015021-pol2qm74	6271	19	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	6271	20	in	in	IN
cord-015021-pol2qm74	6271	21	the	the	DT
cord-015021-pol2qm74	6271	22	setting	setting	NN
cord-015021-pol2qm74	6271	23	of	of	IN
cord-015021-pol2qm74	6271	24	high	high	JJ
cord-015021-pol2qm74	6271	25	concentrations	concentration	NNS
cord-015021-pol2qm74	6271	26	of	of	IN
cord-015021-pol2qm74	6271	27	reactive	reactive	JJ
cord-015021-pol2qm74	6271	28	oxygen	oxygen	NN
cord-015021-pol2qm74	6271	29	metabolites	metabolite	NNS
cord-015021-pol2qm74	6271	30	.	.	.
cord-015021-pol2qm74	6272	1	In	in	IN
cord-015021-pol2qm74	6272	2	addition	addition	NN
cord-015021-pol2qm74	6272	3	,	,	,
cord-015021-pol2qm74	6272	4	in	in	IN
cord-015021-pol2qm74	6272	5	this	this	DT
cord-015021-pol2qm74	6272	6	extracellular	extracellular	JJ
cord-015021-pol2qm74	6272	7	environment	environment	NN
cord-015021-pol2qm74	6272	8	,	,	,
cord-015021-pol2qm74	6272	9	the	the	DT
cord-015021-pol2qm74	6272	10	normal	normal	JJ
cord-015021-pol2qm74	6272	11	antiprotease	antiprotease	NN
cord-015021-pol2qm74	6272	12	defense	defense	NN
cord-015021-pol2qm74	6272	13	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6272	14	of	of	IN
cord-015021-pol2qm74	6272	15	the	the	DT
cord-015021-pol2qm74	6272	16	organism	organism	NN
cord-015021-pol2qm74	6272	17	may	may	MD
cord-015021-pol2qm74	6272	18	have	have	VB
cord-015021-pol2qm74	6272	19	been	be	VBN
cord-015021-pol2qm74	6272	20	severely	severely	RB
cord-015021-pol2qm74	6272	21	inactivated	inactivate	VBN
cord-015021-pol2qm74	6272	22	oxidatively	oxidatively	RB
cord-015021-pol2qm74	6272	23	especially	especially	RB
cord-015021-pol2qm74	6272	24	along	along	IN
cord-015021-pol2qm74	6272	25	capillary	capillary	JJ
cord-015021-pol2qm74	6272	26	endothelial	endothelial	JJ
cord-015021-pol2qm74	6272	27	cells	cell	NNS
cord-015021-pol2qm74	6272	28	.	.	.
cord-015021-pol2qm74	6273	1	Accordingly	accordingly	RB
cord-015021-pol2qm74	6273	2	,	,	,
cord-015021-pol2qm74	6273	3	release	release	NN
cord-015021-pol2qm74	6273	4	of	of	IN
cord-015021-pol2qm74	6273	5	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6273	6	elastase	elastase	NN
cord-015021-pol2qm74	6273	7	which	which	WDT
cord-015021-pol2qm74	6273	8	mediates	mediate	VBZ
cord-015021-pol2qm74	6273	9	inflammation	inflammation	NN
cord-015021-pol2qm74	6273	10	and	and	CC
cord-015021-pol2qm74	6273	11	degrades	degrade	VBZ
cord-015021-pol2qm74	6273	12	most	most	RBS
cord-015021-pol2qm74	6273	13	extracellular	extracellular	JJ
cord-015021-pol2qm74	6273	14	matrix	matrix	NN
cord-015021-pol2qm74	6273	15	proteins	protein	NNS
cord-015021-pol2qm74	6273	16	,	,	,
cord-015021-pol2qm74	6273	17	including	include	VBG
cord-015021-pol2qm74	6273	18	elastin	elastin	NN
cord-015021-pol2qm74	6273	19	,	,	,
cord-015021-pol2qm74	6273	20	fibronectin	fibronectin	NN
cord-015021-pol2qm74	6273	21	and	and	CC
cord-015021-pol2qm74	6273	22	many	many	JJ
cord-015021-pol2qm74	6273	23	forms	form	NNS
cord-015021-pol2qm74	6273	24	of	of	IN
cord-015021-pol2qm74	6273	25	collagen	collagen	NN
cord-015021-pol2qm74	6273	26	,	,	,
cord-015021-pol2qm74	6273	27	may	may	MD
cord-015021-pol2qm74	6273	28	contribute	contribute	VB
cord-015021-pol2qm74	6273	29	to	to	IN
cord-015021-pol2qm74	6273	30	tissue	tissue	NN
cord-015021-pol2qm74	6273	31	injury	injury	NN
cord-015021-pol2qm74	6273	32	and	and	CC
cord-015021-pol2qm74	6273	33	organ	organ	NN
cord-015021-pol2qm74	6273	34	failure	failure	NN
cord-015021-pol2qm74	6273	35	in	in	IN
cord-015021-pol2qm74	6273	36	a	a	DT
cord-015021-pol2qm74	6273	37	variety	variety	NN
cord-015021-pol2qm74	6273	38	of	of	IN
cord-015021-pol2qm74	6273	39	diseases	disease	NNS
cord-015021-pol2qm74	6273	40	ranging	range	VBG
cord-015021-pol2qm74	6273	41	in	in	IN
cord-015021-pol2qm74	6273	42	severity	severity	NN
cord-015021-pol2qm74	6273	43	and	and	CC
cord-015021-pol2qm74	6273	44	acuity	acuity	NN
cord-015021-pol2qm74	6273	45	from	from	IN
cord-015021-pol2qm74	6273	46	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	6273	47	emphysema	emphysema	NN
cord-015021-pol2qm74	6273	48	to	to	IN
cord-015021-pol2qm74	6273	49	the	the	DT
cord-015021-pol2qm74	6273	50	Adult	Adult	NNP
cord-015021-pol2qm74	6273	51	Respiratory	Respiratory	NNP
cord-015021-pol2qm74	6273	52	Distress	Distress	NNP
cord-015021-pol2qm74	6273	53	syndrome	syndrome	NN
cord-015021-pol2qm74	6273	54	(	(	-LRB-
cord-015021-pol2qm74	6273	55	ARDS	ARDS	NNP
cord-015021-pol2qm74	6273	56	)	)	-RRB-
cord-015021-pol2qm74	6273	57	.	.	.
cord-015021-pol2qm74	6274	1	As	as	IN
cord-015021-pol2qm74	6274	2	a	a	DT
cord-015021-pol2qm74	6274	3	result	result	NN
cord-015021-pol2qm74	6274	4	,	,	,
cord-015021-pol2qm74	6274	5	significant	significant	JJ
cord-015021-pol2qm74	6274	6	efforts	effort	NNS
cord-015021-pol2qm74	6274	7	by	by	IN
cord-015021-pol2qm74	6274	8	the	the	DT
cord-015021-pol2qm74	6274	9	pharmaceutical	pharmaceutical	NN
cord-015021-pol2qm74	6274	10	industry	industry	NN
cord-015021-pol2qm74	6274	11	have	have	VBP
cord-015021-pol2qm74	6274	12	been	be	VBN
cord-015021-pol2qm74	6274	13	directed	direct	VBN
cord-015021-pol2qm74	6274	14	not	not	RB
cord-015021-pol2qm74	6274	15	only	only	RB
cord-015021-pol2qm74	6274	16	toward	toward	IN
cord-015021-pol2qm74	6274	17	the	the	DT
cord-015021-pol2qm74	6274	18	development	development	NN
cord-015021-pol2qm74	6274	19	of	of	IN
cord-015021-pol2qm74	6274	20	human	human	JJ
cord-015021-pol2qm74	6274	21	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6274	22	elastase	elastase	NN
cord-015021-pol2qm74	6274	23	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	6274	24	,	,	,
cord-015021-pol2qm74	6274	25	but	but	CC
cord-015021-pol2qm74	6274	26	also	also	RB
cord-015021-pol2qm74	6274	27	toward	toward	IN
cord-015021-pol2qm74	6274	28	their	-PRON-	PRP$
cord-015021-pol2qm74	6274	29	characterization	characterization	NN
cord-015021-pol2qm74	6274	30	in	in	IN
cord-015021-pol2qm74	6274	31	a	a	DT
cord-015021-pol2qm74	6274	32	variety	variety	NN
cord-015021-pol2qm74	6274	33	of	of	IN
cord-015021-pol2qm74	6274	34	animal	animal	NN
cord-015021-pol2qm74	6274	35	models	model	NNS
cord-015021-pol2qm74	6274	36	of	of	IN
cord-015021-pol2qm74	6274	37	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6274	38	mediated	mediate	VBN
cord-015021-pol2qm74	6274	39	diseases	disease	NNS
cord-015021-pol2qm74	6274	40	,	,	,
cord-015021-pol2qm74	6274	41	and	and	CC
cord-015021-pol2qm74	6274	42	their	-PRON-	PRP$
cord-015021-pol2qm74	6274	43	evaluation	evaluation	NN
cord-015021-pol2qm74	6274	44	as	as	IN
cord-015021-pol2qm74	6274	45	potential	potential	JJ
cord-015021-pol2qm74	6274	46	therapeutics	therapeutic	NNS
cord-015021-pol2qm74	6274	47	for	for	IN
cord-015021-pol2qm74	6274	48	the	the	DT
cord-015021-pol2qm74	6274	49	treatment	treatment	NN
cord-015021-pol2qm74	6274	50	of	of	IN
cord-015021-pol2qm74	6274	51	a	a	DT
cord-015021-pol2qm74	6274	52	variety	variety	NN
cord-015021-pol2qm74	6274	53	of	of	IN
cord-015021-pol2qm74	6274	54	human	human	JJ
cord-015021-pol2qm74	6274	55	clinical	clinical	JJ
cord-015021-pol2qm74	6274	56	conditions	condition	NNS
cord-015021-pol2qm74	6274	57	.	.	.
cord-015021-pol2qm74	6275	1	Data	datum	NNS
cord-015021-pol2qm74	6275	2	from	from	IN
cord-015021-pol2qm74	6275	3	animal	animal	NN
cord-015021-pol2qm74	6275	4	models	model	NNS
cord-015021-pol2qm74	6275	5	of	of	IN
cord-015021-pol2qm74	6275	6	organ	organ	NN
cord-015021-pol2qm74	6275	7	injury	injury	NN
cord-015021-pol2qm74	6275	8	and	and	CC
cord-015021-pol2qm74	6275	9	failure	failure	NN
cord-015021-pol2qm74	6275	10	along	along	IN
cord-015021-pol2qm74	6275	11	with	with	IN
cord-015021-pol2qm74	6275	12	data	datum	NNS
cord-015021-pol2qm74	6275	13	collected	collect	VBN
cord-015021-pol2qm74	6275	14	from	from	IN
cord-015021-pol2qm74	6275	15	a	a	DT
cord-015021-pol2qm74	6275	16	series	series	NN
cord-015021-pol2qm74	6275	17	of	of	IN
cord-015021-pol2qm74	6275	18	patients	patient	NNS
cord-015021-pol2qm74	6275	19	at	at	IN
cord-015021-pol2qm74	6275	20	risk	risk	NN
cord-015021-pol2qm74	6275	21	for	for	IN
cord-015021-pol2qm74	6275	22	ARDS	ARDS	NNP
cord-015021-pol2qm74	6275	23	and	and	CC
cord-015021-pol2qm74	6275	24	with	with	IN
cord-015021-pol2qm74	6275	25	ARDS	ARDS	NNP
cord-015021-pol2qm74	6275	26	will	will	MD
cord-015021-pol2qm74	6275	27	be	be	VB
cord-015021-pol2qm74	6275	28	presented	present	VBN
cord-015021-pol2qm74	6275	29	and	and	CC
cord-015021-pol2qm74	6275	30	discussed	discuss	VBN
cord-015021-pol2qm74	6275	31	as	as	IN
cord-015021-pol2qm74	6275	32	a	a	DT
cord-015021-pol2qm74	6275	33	rationale	rationale	NN
cord-015021-pol2qm74	6275	34	for	for	IN
cord-015021-pol2qm74	6275	35	inhibition	inhibition	NN
cord-015021-pol2qm74	6275	36	of	of	IN
cord-015021-pol2qm74	6275	37	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6275	38	elastase	elastase	NN
cord-015021-pol2qm74	6275	39	.	.	.
cord-015021-pol2qm74	6276	1	Parameters	parameter	NNS
cord-015021-pol2qm74	6276	2	that	that	WDT
cord-015021-pol2qm74	6276	3	need	need	VBP
cord-015021-pol2qm74	6276	4	to	to	TO
cord-015021-pol2qm74	6276	5	be	be	VB
cord-015021-pol2qm74	6276	6	monitored	monitor	VBN
cord-015021-pol2qm74	6276	7	to	to	TO
cord-015021-pol2qm74	6276	8	obtain	obtain	VB
cord-015021-pol2qm74	6276	9	success	success	NN
cord-015021-pol2qm74	6276	10	in	in	IN
cord-015021-pol2qm74	6276	11	future	future	JJ
cord-015021-pol2qm74	6276	12	clinical	clinical	JJ
cord-015021-pol2qm74	6276	13	studies	study	NNS
cord-015021-pol2qm74	6276	14	will	will	MD
cord-015021-pol2qm74	6276	15	also	also	RB
cord-015021-pol2qm74	6276	16	be	be	VB
cord-015021-pol2qm74	6276	17	presented	present	VBN
cord-015021-pol2qm74	6276	18	in	in	IN
cord-015021-pol2qm74	6276	19	this	this	DT
cord-015021-pol2qm74	6276	20	context	context	NN
cord-015021-pol2qm74	6276	21	.	.	.
cord-015021-pol2qm74	6277	1	have	have	VBP
cord-015021-pol2qm74	6277	2	turned	turn	VBN
cord-015021-pol2qm74	6277	3	out	out	RP
cord-015021-pol2qm74	6277	4	to	to	TO
cord-015021-pol2qm74	6277	5	initiate	initiate	VB
cord-015021-pol2qm74	6277	6	and	and	CC
cord-015021-pol2qm74	6277	7	maintain	maintain	VB
cord-015021-pol2qm74	6277	8	organ	organ	NN
cord-015021-pol2qm74	6277	9	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	6277	10	in	in	IN
cord-015021-pol2qm74	6277	11	severe	severe	JJ
cord-015021-pol2qm74	6277	12	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	6277	13	and	and	CC
cord-015021-pol2qm74	6277	14	postoperative	postoperative	JJ
cord-015021-pol2qm74	6277	15	courses	course	NNS
cord-015021-pol2qm74	6277	16	.	.	.
cord-015021-pol2qm74	6278	1	Such	such	JJ
cord-015021-pol2qm74	6278	2	proteolysis	proteolysis	NN
cord-015021-pol2qm74	6278	3	-	-	HYPH
cord-015021-pol2qm74	6278	4	induced	induce	VBN
cord-015021-pol2qm74	6278	5	disorders	disorder	NNS
cord-015021-pol2qm74	6278	6	are	be	VBP
cord-015021-pol2qm74	6278	7	especially	especially	RB
cord-015021-pol2qm74	6278	8	rendered	render	VBN
cord-015021-pol2qm74	6278	9	possible	possible	JJ
cord-015021-pol2qm74	6278	10	by	by	IN
cord-015021-pol2qm74	6278	11	the	the	DT
cord-015021-pol2qm74	6278	12	concurrently	concurrently	RB
cord-015021-pol2qm74	6278	13	arising	arise	VBG
cord-015021-pol2qm74	6278	14	consumption	consumption	NN
cord-015021-pol2qm74	6278	15	of	of	IN
cord-015021-pol2qm74	6278	16	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	6278	17	regulators	regulator	NNS
cord-015021-pol2qm74	6278	18	(	(	-LRB-
cord-015021-pol2qm74	6278	19	e.g.	e.g.	RB
cord-015021-pol2qm74	6278	20	a	a	DT
cord-015021-pol2qm74	6278	21	Vproteinase	Vproteinase	NNP
cord-015021-pol2qm74	6278	22	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6278	23	=	=	VBZ
cord-015021-pol2qm74	6278	24	a	a	DT
cord-015021-pol2qm74	6278	25	1PI	1pi	CD
cord-015021-pol2qm74	6278	26	,	,	,
cord-015021-pol2qm74	6278	27	antithrombin	antithrombin	NN
cord-015021-pol2qm74	6278	28	III	III	NNP
cord-015021-pol2qm74	6278	29	=	=	SYM
cord-015021-pol2qm74	6278	30	AT	at	IN
cord-015021-pol2qm74	6278	31	III	III	NNP
cord-015021-pol2qm74	6278	32	)	)	-RRB-
cord-015021-pol2qm74	6278	33	via	via	IN
cord-015021-pol2qm74	6278	34	cofnplex	cofnplex	NN
cord-015021-pol2qm74	6278	35	formation	formation	NN
cord-015021-pol2qm74	6278	36	and	and	CC
cord-015021-pol2qm74	6278	37	/	/	SYM
cord-015021-pol2qm74	6278	38	of	of	IN
cord-015021-pol2qm74	6278	39	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	6278	40	/	/	SYM
cord-015021-pol2qm74	6278	41	oxidative	oxidative	JJ
cord-015021-pol2qm74	6278	42	inactivation	inactivation	NN
cord-015021-pol2qm74	6278	43	.	.	.
cord-015021-pol2qm74	6279	1	Besides	besides	IN
cord-015021-pol2qm74	6279	2	the	the	DT
cord-015021-pol2qm74	6279	3	well	well	RB
cord-015021-pol2qm74	6279	4	-	-	HYPH
cord-015021-pol2qm74	6279	5	known	know	VBN
cord-015021-pol2qm74	6279	6	destructive	destructive	JJ
cord-015021-pol2qm74	6279	7	potency	potency	NN
cord-015021-pol2qm74	6279	8	against	against	IN
cord-015021-pol2qm74	6279	9	protein	protein	NN
cord-015021-pol2qm74	6279	10	substrates	substrate	NNS
cord-015021-pol2qm74	6279	11	,	,	,
cord-015021-pol2qm74	6279	12	proteinases	proteinase	VBZ
cord-015021-pol2qm74	6279	13	such	such	JJ
cord-015021-pol2qm74	6279	14	as	as	IN
cord-015021-pol2qm74	6279	15	elastase	elastase	NN
cord-015021-pol2qm74	6279	16	or	or	CC
cord-015021-pol2qm74	6279	17	thrombin	thrombin	NN
cord-015021-pol2qm74	6279	18	(	(	-LRB-
cord-015021-pol2qm74	6279	19	active	active	JJ
cord-015021-pol2qm74	6279	20	or	or	CC
cord-015021-pol2qm74	6279	21	in	in	IN
cord-015021-pol2qm74	6279	22	complex	complex	NN
cord-015021-pol2qm74	6279	23	with	with	IN
cord-015021-pol2qm74	6279	24	the	the	DT
cord-015021-pol2qm74	6279	25	serpin	serpin	NN
cord-015021-pol2qm74	6279	26	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	6279	27	~	~	NFP
cord-015021-pol2qm74	6279	28	1PI	1pi	CD
cord-015021-pol2qm74	6279	29	or	or	CC
cord-015021-pol2qm74	6279	30	AT	AT	NNP
cord-015021-pol2qm74	6279	31	III	III	NNP
cord-015021-pol2qm74	6279	32	)	)	-RRB-
cord-015021-pol2qm74	6279	33	are	be	VBP
cord-015021-pol2qm74	6279	34	also	also	RB
cord-015021-pol2qm74	6279	35	supposed	suppose	VBN
cord-015021-pol2qm74	6279	36	to	to	TO
cord-015021-pol2qm74	6279	37	increase	increase	VB
cord-015021-pol2qm74	6279	38	the	the	DT
cord-015021-pol2qm74	6279	39	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6279	40	reaction	reaction	NN
cord-015021-pol2qm74	6279	41	by	by	IN
cord-015021-pol2qm74	6279	42	inducing	induce	VBG
cord-015021-pol2qm74	6279	43	cytokine	cytokine	NN
cord-015021-pol2qm74	6279	44	release	release	NN
cord-015021-pol2qm74	6279	45	or	or	CC
cord-015021-pol2qm74	6279	46	shedding	shedding	NN
cord-015021-pol2qm74	6279	47	of	of	IN
cord-015021-pol2qm74	6279	48	soIuble	soIuble	NNP
cord-015021-pol2qm74	6279	49	adhesion	adhesion	NN
cord-015021-pol2qm74	6279	50	molecules	molecule	NNS
cord-015021-pol2qm74	6279	51	from	from	IN
cord-015021-pol2qm74	6279	52	various	various	JJ
cord-015021-pol2qm74	6279	53	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6279	54	cells	cell	NNS
cord-015021-pol2qm74	6279	55	(	(	-LRB-
cord-015021-pol2qm74	6279	56	PMNs	pmn	NNS
cord-015021-pol2qm74	6279	57	,	,	,
cord-015021-pol2qm74	6279	58	monocytes	monocyte	NNS
cord-015021-pol2qm74	6279	59	/	/	SYM
cord-015021-pol2qm74	6279	60	macrophages	macrophage	NNS
cord-015021-pol2qm74	6279	61	,	,	,
cord-015021-pol2qm74	6279	62	endothelial	endothelial	JJ
cord-015021-pol2qm74	6279	63	cells	cell	NNS
cord-015021-pol2qm74	6279	64	)	)	-RRB-
cord-015021-pol2qm74	6279	65	.	.	.
cord-015021-pol2qm74	6280	1	Those	those	DT
cord-015021-pol2qm74	6280	2	cell	cell	NN
cord-015021-pol2qm74	6280	3	-	-	HYPH
cord-015021-pol2qm74	6280	4	derived	derive	VBN
cord-015021-pol2qm74	6280	5	mediators	mediator	NNS
cord-015021-pol2qm74	6280	6	may	may	MD
cord-015021-pol2qm74	6280	7	provoke	provoke	VB
cord-015021-pol2qm74	6280	8	further	further	JJ
cord-015021-pol2qm74	6280	9	cell	cell	NN
cord-015021-pol2qm74	6280	10	activation	activation	NN
cord-015021-pol2qm74	6280	11	through	through	IN
cord-015021-pol2qm74	6280	12	an	an	DT
cord-015021-pol2qm74	6280	13	autocrine	autocrine	JJ
cord-015021-pol2qm74	6280	14	/	/	SYM
cord-015021-pol2qm74	6280	15	paracrine	paracrine	NN
cord-015021-pol2qm74	6280	16	loop	loop	NN
cord-015021-pol2qm74	6280	17	thus	thus	RB
cord-015021-pol2qm74	6280	18	increasing	increase	VBG
cord-015021-pol2qm74	6280	19	significantly	significantly	RB
cord-015021-pol2qm74	6280	20	the	the	DT
cord-015021-pol2qm74	6280	21	proteinase	proteinase	NN
cord-015021-pol2qm74	6280	22	burden	burden	NN
cord-015021-pol2qm74	6280	23	at	at	IN
cord-015021-pol2qm74	6280	24	the	the	DT
cord-015021-pol2qm74	6280	25	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6280	26	focus	focus	NN
cord-015021-pol2qm74	6280	27	.	.	.
cord-015021-pol2qm74	6281	1	Therefore	therefore	RB
cord-015021-pol2qm74	6281	2	,	,	,
cord-015021-pol2qm74	6281	3	this	this	DT
cord-015021-pol2qm74	6281	4	noxious	noxious	JJ
cord-015021-pol2qm74	6281	5	circle	circle	NN
cord-015021-pol2qm74	6281	6	might	may	MD
cord-015021-pol2qm74	6281	7	be	be	VB
cord-015021-pol2qm74	6281	8	interrupted	interrupt	VBN
cord-015021-pol2qm74	6281	9	by	by	IN
cord-015021-pol2qm74	6281	10	a	a	DT
cord-015021-pol2qm74	6281	11	convenient	convenient	JJ
cord-015021-pol2qm74	6281	12	proteinase	proteinase	NN
cord-015021-pol2qm74	6281	13	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6281	14	therapy	therapy	NN
cord-015021-pol2qm74	6281	15	to	to	TO
cord-015021-pol2qm74	6281	16	ameliorate	ameliorate	VB
cord-015021-pol2qm74	6281	17	the	the	DT
cord-015021-pol2qm74	6281	18	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6281	19	process	process	NN
cord-015021-pol2qm74	6281	20	.	.	.
cord-015021-pol2qm74	6282	1	To	to	TO
cord-015021-pol2qm74	6282	2	verify	verify	VB
cord-015021-pol2qm74	6282	3	this	this	DT
cord-015021-pol2qm74	6282	4	hypothesis	hypothesis	NN
cord-015021-pol2qm74	6282	5	,	,	,
cord-015021-pol2qm74	6282	6	high	high	JJ
cord-015021-pol2qm74	6282	7	dosis	dosis	NN
cord-015021-pol2qm74	6282	8	of	of	IN
cord-015021-pol2qm74	6282	9	AT	AT	NNP
cord-015021-pol2qm74	6282	10	III	III	NNP
cord-015021-pol2qm74	6283	1	(	(	-LRB-
cord-015021-pol2qm74	6283	2	mean	mean	VB
cord-015021-pol2qm74	6283	3	plasma	plasma	NN
cord-015021-pol2qm74	6283	4	levels	level	NNS
cord-015021-pol2qm74	6283	5	up	up	IN
cord-015021-pol2qm74	6283	6	to	to	IN
cord-015021-pol2qm74	6283	7	140	140	CD
cord-015021-pol2qm74	6283	8	%	%	NN
cord-015021-pol2qm74	6283	9	)	)	-RRB-
cord-015021-pol2qm74	6283	10	were	be	VBD
cord-015021-pol2qm74	6283	11	applied	apply	VBN
cord-015021-pol2qm74	6283	12	in	in	IN
cord-015021-pol2qm74	6283	13	first	first	RB
cord-015021-pol2qm74	6283	14	controlled	control	VBN
cord-015021-pol2qm74	6283	15	randomized	randomized	JJ
cord-015021-pol2qm74	6283	16	studies	study	NNS
cord-015021-pol2qm74	6283	17	on	on	IN
cord-015021-pol2qm74	6283	18	surgical	surgical	JJ
cord-015021-pol2qm74	6283	19	patients	patient	NNS
cord-015021-pol2qm74	6283	20	suffering	suffer	VBG
cord-015021-pol2qm74	6283	21	from	from	IN
cord-015021-pol2qm74	6283	22	multiple	multiple	JJ
cord-015021-pol2qm74	6283	23	trauma	trauma	NN
cord-015021-pol2qm74	6283	24	or	or	CC
cord-015021-pol2qm74	6283	25	severe	severe	JJ
cord-015021-pol2qm74	6283	26	sepsis	sepsis	NN
cord-015021-pol2qm74	6283	27	.	.	.
cord-015021-pol2qm74	6284	1	In	in	IN
cord-015021-pol2qm74	6284	2	control	control	NN
cord-015021-pol2qm74	6284	3	patients	patient	NNS
cord-015021-pol2qm74	6284	4	we	-PRON-	PRP
cord-015021-pol2qm74	6284	5	could	could	MD
cord-015021-pol2qm74	6284	6	clearly	clearly	RB
cord-015021-pol2qm74	6284	7	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6284	8	the	the	DT
cord-015021-pol2qm74	6284	9	sequential	sequential	JJ
cord-015021-pol2qm74	6284	10	appearance	appearance	NN
cord-015021-pol2qm74	6284	11	of	of	IN
cord-015021-pol2qm74	6284	12	proteinase	proteinase	NN
cord-015021-pol2qm74	6284	13	/	/	SYM
cord-015021-pol2qm74	6284	14	serpin	serpin	NN
cord-015021-pol2qm74	6284	15	-	-	HYPH
cord-015021-pol2qm74	6284	16	complexes	complex	NNS
cord-015021-pol2qm74	6284	17	(	(	-LRB-
cord-015021-pol2qm74	6284	18	Fa	Fa	NNP
cord-015021-pol2qm74	6284	19	1PI	1PI	NNP
cord-015021-pol2qm74	6284	20	,	,	,
cord-015021-pol2qm74	6284	21	TAT	TAT	NNP
cord-015021-pol2qm74	6284	22	)	)	-RRB-
cord-015021-pol2qm74	6284	23	,	,	,
cord-015021-pol2qm74	6284	24	cytokines	cytokine	NNS
cord-015021-pol2qm74	6284	25	(	(	-LRB-
cord-015021-pol2qm74	6284	26	IL-8	IL-8	NNP
cord-015021-pol2qm74	6284	27	,	,	,
cord-015021-pol2qm74	6284	28	IL-6	IL-6	NNP
cord-015021-pol2qm74	6284	29	)	)	-RRB-
cord-015021-pol2qm74	6284	30	,	,	,
cord-015021-pol2qm74	6284	31	and	and	CC
cord-015021-pol2qm74	6284	32	soluble	soluble	JJ
cord-015021-pol2qm74	6284	33	intercellular	intercellular	JJ
cord-015021-pol2qm74	6284	34	adh6sion	adh6sion	NN
cord-015021-pol2qm74	6284	35	molecules	molecule	NNS
cord-015021-pol2qm74	6284	36	(	(	-LRB-
cord-015021-pol2qm74	6284	37	ICAM	ICAM	NNP
cord-015021-pol2qm74	6284	38	,	,	,
cord-015021-pol2qm74	6284	39	ELAN	ELAN	NNP
cord-015021-pol2qm74	6284	40	,	,	,
cord-015021-pol2qm74	6284	41	P	p	NN
cord-015021-pol2qm74	6284	42	-	-	HYPH
cord-015021-pol2qm74	6284	43	selectin	selectin	NNP
cord-015021-pol2qm74	6284	44	)	)	-RRB-
cord-015021-pol2qm74	6284	45	in	in	IN
cord-015021-pol2qm74	6284	46	the	the	DT
cord-015021-pol2qm74	6284	47	circulation	circulation	NN
cord-015021-pol2qm74	6284	48	.	.	.
cord-015021-pol2qm74	6285	1	These	these	DT
cord-015021-pol2qm74	6285	2	factors	factor	NNS
cord-015021-pol2qm74	6285	3	turned	turn	VBD
cord-015021-pol2qm74	6285	4	out	out	RP
cord-015021-pol2qm74	6285	5	to	to	TO
cord-015021-pol2qm74	6285	6	be	be	VB
cord-015021-pol2qm74	6285	7	a	a	DT
cord-015021-pol2qm74	6285	8	helpful	helpful	JJ
cord-015021-pol2qm74	6285	9	tool	tool	NN
cord-015021-pol2qm74	6285	10	for	for	IN
cord-015021-pol2qm74	6285	11	early	early	JJ
cord-015021-pol2qm74	6285	12	diagnosis	diagnosis	NN
cord-015021-pol2qm74	6285	13	and	and	CC
cord-015021-pol2qm74	6285	14	prognosis	prognosis	NN
cord-015021-pol2qm74	6285	15	of	of	IN
cord-015021-pol2qm74	6285	16	forthcoming	forthcoming	JJ
cord-015021-pol2qm74	6285	17	organ	organ	NN
cord-015021-pol2qm74	6285	18	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	6285	19	.	.	.
cord-015021-pol2qm74	6286	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	6286	2	,	,	,
cord-015021-pol2qm74	6286	3	m	m	NNP
cord-015021-pol2qm74	6286	4	AT	AT	NNP
cord-015021-pol2qm74	6286	5	III	III	NNP
cord-015021-pol2qm74	6286	6	-	-	HYPH
cord-015021-pol2qm74	6286	7	treated	treat	VBN
cord-015021-pol2qm74	6286	8	patients	patient	NNS
cord-015021-pol2qm74	6286	9	a	a	DT
cord-015021-pol2qm74	6286	10	significantly	significantly	RB
cord-015021-pol2qm74	6286	11	reduced	reduce	VBN
cord-015021-pol2qm74	6286	12	release	release	NN
cord-015021-pol2qm74	6286	13	/	/	SYM
cord-015021-pol2qm74	6286	14	production	production	NN
cord-015021-pol2qm74	6286	15	of	of	IN
cord-015021-pol2qm74	6286	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6286	17	mediators	mediator	NNS
cord-015021-pol2qm74	6286	18	became	become	VBD
cord-015021-pol2qm74	6286	19	obvious	obvious	JJ
cord-015021-pol2qm74	6286	20	concomitant	concomitant	JJ
cord-015021-pol2qm74	6286	21	with	with	IN
cord-015021-pol2qm74	6286	22	the	the	DT
cord-015021-pol2qm74	6286	23	improved	improve	VBN
cord-015021-pol2qm74	6286	24	clinical	clinical	JJ
cord-015021-pol2qm74	6286	25	course	course	NN
cord-015021-pol2qm74	6286	26	in	in	IN
cord-015021-pol2qm74	6286	27	comparision	comparision	NN
cord-015021-pol2qm74	6286	28	to	to	IN
cord-015021-pol2qm74	6286	29	an	an	DT
cord-015021-pol2qm74	6286	30	increasing	increase	VBG
cord-015021-pol2qm74	6286	31	deterioration	deterioration	NN
cord-015021-pol2qm74	6286	32	in	in	IN
cord-015021-pol2qm74	6286	33	control	control	NN
cord-015021-pol2qm74	6286	34	patients	patient	NNS
cord-015021-pol2qm74	6286	35	.	.	.
cord-015021-pol2qm74	6287	1	Soluble	soluble	JJ
cord-015021-pol2qm74	6287	2	mediators	mediator	NNS
cord-015021-pol2qm74	6287	3	of	of	IN
cord-015021-pol2qm74	6287	4	inflammation	inflammation	NN
cord-015021-pol2qm74	6287	5	are	be	VBP
cord-015021-pol2qm74	6287	6	cytokines	cytokine	NNS
cord-015021-pol2qm74	6287	7	(	(	-LRB-
cord-015021-pol2qm74	6287	8	e.g.	e.g.	RB
cord-015021-pol2qm74	6287	9	IL-1	IL-1	NNP
cord-015021-pol2qm74	6287	10	,	,	,
cord-015021-pol2qm74	6287	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	6287	12	and	and	CC
cord-015021-pol2qm74	6287	13	TNFe	TNFe	NNP
cord-015021-pol2qm74	6287	14	)	)	-RRB-
cord-015021-pol2qm74	6287	15	as	as	RB
cord-015021-pol2qm74	6287	16	well	well	RB
cord-015021-pol2qm74	6287	17	as	as	IN
cord-015021-pol2qm74	6287	18	breakdown	breakdown	NN
cord-015021-pol2qm74	6287	19	products	product	NNS
cord-015021-pol2qm74	6287	20	of	of	IN
cord-015021-pol2qm74	6287	21	complement	complement	NN
cord-015021-pol2qm74	6287	22	proteins	protein	NNS
cord-015021-pol2qm74	6287	23	(	(	-LRB-
cord-015021-pol2qm74	6287	24	e.g.	e.g.	IN
cord-015021-pol2qm74	6287	25	C5a	C5a	NNS
cord-015021-pol2qm74	6287	26	and	and	CC
cord-015021-pol2qm74	6287	27	terminal	terminal	NN
cord-015021-pol2qm74	6287	28	complement	complement	NN
cord-015021-pol2qm74	6287	29	complex	complex	NN
cord-015021-pol2qm74	6287	30	)	)	-RRB-
cord-015021-pol2qm74	6287	31	.	.	.
cord-015021-pol2qm74	6288	1	Therefore	therefore	RB
cord-015021-pol2qm74	6288	2	,	,	,
cord-015021-pol2qm74	6288	3	attenuation	attenuation	NN
cord-015021-pol2qm74	6288	4	of	of	IN
cord-015021-pol2qm74	6288	5	both	both	DT
cord-015021-pol2qm74	6288	6	,	,	,
cord-015021-pol2qm74	6288	7	release	release	NN
cord-015021-pol2qm74	6288	8	and	and	CC
cord-015021-pol2qm74	6288	9	generation	generation	NN
cord-015021-pol2qm74	6288	10	of	of	IN
cord-015021-pol2qm74	6288	11	these	these	DT
cord-015021-pol2qm74	6288	12	synergistically	synergistically	RB
cord-015021-pol2qm74	6288	13	functioning	function	VBG
cord-015021-pol2qm74	6288	14	mediators	mediator	NNS
cord-015021-pol2qm74	6288	15	together	together	RB
cord-015021-pol2qm74	6288	16	with	with	IN
cord-015021-pol2qm74	6288	17	stimulation	stimulation	NN
cord-015021-pol2qm74	6288	18	of	of	IN
cord-015021-pol2qm74	6288	19	release	release	NN
cord-015021-pol2qm74	6288	20	of	of	IN
cord-015021-pol2qm74	6288	21	antagonists	antagonist	NNS
cord-015021-pol2qm74	6288	22	including	include	VBG
cord-015021-pol2qm74	6288	23	soluble	soluble	JJ
cord-015021-pol2qm74	6288	24	forms	form	NNS
cord-015021-pol2qm74	6288	25	of	of	IN
cord-015021-pol2qm74	6288	26	receptors	receptor	NNS
cord-015021-pol2qm74	6288	27	are	be	VBP
cord-015021-pol2qm74	6288	28	potentially	potentially	RB
cord-015021-pol2qm74	6288	29	beneficial	beneficial	JJ
cord-015021-pol2qm74	6288	30	in	in	IN
cord-015021-pol2qm74	6288	31	all	all	DT
cord-015021-pol2qm74	6288	32	kind	kind	NN
cord-015021-pol2qm74	6288	33	of	of	IN
cord-015021-pol2qm74	6288	34	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6288	35	diseases	disease	NNS
cord-015021-pol2qm74	6288	36	.	.	.
cord-015021-pol2qm74	6289	1	Intravenous	intravenous	JJ
cord-015021-pol2qm74	6289	2	immunoglobulins	immunoglobulin	NNS
cord-015021-pol2qm74	6289	3	(	(	-LRB-
cord-015021-pol2qm74	6289	4	IVIGs	ivig	NNS
cord-015021-pol2qm74	6289	5	)	)	-RRB-
cord-015021-pol2qm74	6289	6	are	be	VBP
cord-015021-pol2qm74	6289	7	known	know	VBN
cord-015021-pol2qm74	6289	8	to	to	TO
cord-015021-pol2qm74	6289	9	have	have	VB
cord-015021-pol2qm74	6289	10	an	an	DT
cord-015021-pol2qm74	6289	11	anti	anti	JJ
cord-015021-pol2qm74	6289	12	-	-	JJ
cord-015021-pol2qm74	6289	13	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6289	14	effect	effect	NN
cord-015021-pol2qm74	6289	15	in	in	IN
cord-015021-pol2qm74	6289	16	humans	human	NNS
cord-015021-pol2qm74	6289	17	(	(	-LRB-
cord-015021-pol2qm74	6289	18	NIH	NIH	NNP
cord-015021-pol2qm74	6289	19	Consensus	Consensus	NNP
cord-015021-pol2qm74	6289	20	Conference	Conference	NNP
cord-015021-pol2qm74	6289	21	on	on	IN
cord-015021-pol2qm74	6289	22	WIG	WIG	NNP
cord-015021-pol2qm74	6289	23	,	,	,
cord-015021-pol2qm74	6289	24	1990	1990	CD
cord-015021-pol2qm74	6289	25	)	)	-RRB-
cord-015021-pol2qm74	6289	26	.	.	.
cord-015021-pol2qm74	6290	1	The	the	DT
cord-015021-pol2qm74	6290	2	mechanism	mechanism	NN
cord-015021-pol2qm74	6290	3	of	of	IN
cord-015021-pol2qm74	6290	4	action	action	NN
cord-015021-pol2qm74	6290	5	becomes	become	VBZ
cord-015021-pol2qm74	6290	6	more	more	RBR
cord-015021-pol2qm74	6290	7	and	and	CC
cord-015021-pol2qm74	6290	8	more	more	RBR
cord-015021-pol2qm74	6290	9	clear	clear	JJ
cord-015021-pol2qm74	6290	10	.	.	.
cord-015021-pol2qm74	6291	1	In	in	IN
cord-015021-pol2qm74	6291	2	single	single	JJ
cord-015021-pol2qm74	6291	3	cells	cell	NNS
cord-015021-pol2qm74	6291	4	stimulated	stimulate	VBN
cord-015021-pol2qm74	6291	5	by	by	IN
cord-015021-pol2qm74	6291	6	anti	anti	JJ
cord-015021-pol2qm74	6291	7	-	-	JJ
cord-015021-pol2qm74	6291	8	CD3	cd3	JJ
cord-015021-pol2qm74	6291	9	mAb	mab	NN
cord-015021-pol2qm74	6291	10	WIG	WIG	NNP
cord-015021-pol2qm74	6291	11	was	be	VBD
cord-015021-pol2qm74	6291	12	able	able	JJ
cord-015021-pol2qm74	6291	13	to	to	TO
cord-015021-pol2qm74	6291	14	down	down	VB
cord-015021-pol2qm74	6291	15	-	-	HYPH
cord-015021-pol2qm74	6291	16	regulate	regulate	VB
cord-015021-pol2qm74	6291	17	production	production	NN
cord-015021-pol2qm74	6291	18	of	of	IN
cord-015021-pol2qm74	6291	19	IL-2	IL-2	NNP
cord-015021-pol2qm74	6291	20	,	,	,
cord-015021-pol2qm74	6291	21	IL-10	IL-10	NNP
cord-015021-pol2qm74	6291	22	,	,	,
cord-015021-pol2qm74	6291	23	IFN%	IFN%	NNP
cord-015021-pol2qm74	6291	24	and	and	CC
cord-015021-pol2qm74	6291	25	TNFJ~	TNFJ~	NNP
cord-015021-pol2qm74	6291	26	significantly	significantly	RB
cord-015021-pol2qm74	6291	27	.	.	.
cord-015021-pol2qm74	6292	1	IgG	IgG	NNP
cord-015021-pol2qm74	6292	2	coated	coat	VBD
cord-015021-pol2qm74	6292	3	solid	solid	JJ
cord-015021-pol2qm74	6292	4	-	-	HYPH
cord-015021-pol2qm74	6292	5	phase	phase	NN
cord-015021-pol2qm74	6292	6	stimulates	stimulate	VBZ
cord-015021-pol2qm74	6292	7	release	release	NN
cord-015021-pol2qm74	6292	8	from	from	IN
cord-015021-pol2qm74	6292	9	monocytes	monocyte	NNS
cord-015021-pol2qm74	6292	10	of	of	IN
cord-015021-pol2qm74	6292	11	interleukin-1	interleukin-1	NNP
cord-015021-pol2qm74	6292	12	receptor	receptor	NN
cord-015021-pol2qm74	6292	13	antagonist	antagonist	NN
cord-015021-pol2qm74	6292	14	(	(	-LRB-
cord-015021-pol2qm74	6292	15	IL	IL	NNP
cord-015021-pol2qm74	6292	16	-	-	HYPH
cord-015021-pol2qm74	6292	17	lra	lra	NNP
cord-015021-pol2qm74	6292	18	)	)	-RRB-
cord-015021-pol2qm74	6292	19	but	but	CC
cord-015021-pol2qm74	6292	20	not	not	RB
cord-015021-pol2qm74	6292	21	of	of	IN
cord-015021-pol2qm74	6292	22	IL-1	IL-1	NNP
cord-015021-pol2qm74	6292	23	;	;	:
cord-015021-pol2qm74	6292	24	this	this	DT
cord-015021-pol2qm74	6292	25	observation	observation	NN
cord-015021-pol2qm74	6292	26	is	be	VBZ
cord-015021-pol2qm74	6292	27	very	very	RB
cord-015021-pol2qm74	6292	28	much	much	RB
cord-015021-pol2qm74	6292	29	in	in	IN
cord-015021-pol2qm74	6292	30	contrast	contrast	NN
cord-015021-pol2qm74	6292	31	to	to	IN
cord-015021-pol2qm74	6292	32	the	the	DT
cord-015021-pol2qm74	6292	33	effect	effect	NN
cord-015021-pol2qm74	6292	34	of	of	IN
cord-015021-pol2qm74	6292	35	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6292	36	in	in	IN
cord-015021-pol2qm74	6292	37	the	the	DT
cord-015021-pol2qm74	6292	38	same	same	JJ
cord-015021-pol2qm74	6292	39	in	in	IN
cord-015021-pol2qm74	6292	40	vitro	vitro	FW
cord-015021-pol2qm74	6292	41	system	system	NN
cord-015021-pol2qm74	6292	42	.	.	.
cord-015021-pol2qm74	6293	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	6293	2	,	,	,
cord-015021-pol2qm74	6293	3	naturally	naturally	RB
cord-015021-pol2qm74	6293	4	occurring	occur	VBG
cord-015021-pol2qm74	6293	5	anti	anti	JJ
cord-015021-pol2qm74	6293	6	-	-	JJ
cord-015021-pol2qm74	6293	7	cytokine	cytokine	JJ
cord-015021-pol2qm74	6293	8	antibodies	antibody	NNS
cord-015021-pol2qm74	6293	9	can	can	MD
cord-015021-pol2qm74	6293	10	be	be	VB
cord-015021-pol2qm74	6293	11	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	6293	12	in	in	IN
cord-015021-pol2qm74	6293	13	apparently	apparently	RB
cord-015021-pol2qm74	6293	14	healthy	healthy	JJ
cord-015021-pol2qm74	6293	15	individuals	individual	NNS
cord-015021-pol2qm74	6293	16	and	and	CC
cord-015021-pol2qm74	6293	17	in	in	IN
cord-015021-pol2qm74	6293	18	WIG	wig	NN
cord-015021-pol2qm74	6293	19	prepared	prepare	VBN
cord-015021-pol2qm74	6293	20	from	from	IN
cord-015021-pol2qm74	6293	21	plasma	plasma	NN
cord-015021-pol2qm74	6293	22	pools	pool	NNS
cord-015021-pol2qm74	6293	23	.	.	.
cord-015021-pol2qm74	6294	1	Some	some	DT
cord-015021-pol2qm74	6294	2	of	of	IN
cord-015021-pol2qm74	6294	3	these	these	DT
cord-015021-pol2qm74	6294	4	antibodies	antibody	NNS
cord-015021-pol2qm74	6294	5	can	can	MD
cord-015021-pol2qm74	6294	6	be	be	VB
cord-015021-pol2qm74	6294	7	detected	detect	VBN
cord-015021-pol2qm74	6294	8	by	by	IN
cord-015021-pol2qm74	6294	9	antigen	antigen	NN
cord-015021-pol2qm74	6294	10	/	/	SYM
cord-015021-pol2qm74	6294	11	antibody	antibody	NN
cord-015021-pol2qm74	6294	12	reactions	reaction	NNS
cord-015021-pol2qm74	6294	13	in	in	IN
cord-015021-pol2qm74	6294	14	fluid	fluid	JJ
cord-015021-pol2qm74	6294	15	phase	phase	NN
cord-015021-pol2qm74	6294	16	(	(	-LRB-
cord-015021-pol2qm74	6294	17	anti	anti	JJ
cord-015021-pol2qm74	6294	18	-	-	JJ
cord-015021-pol2qm74	6294	19	lL	ll	JJ
cord-015021-pol2qm74	6294	20	-	-	HYPH
cord-015021-pol2qm74	6294	21	le	le	NNP
cord-015021-pol2qm74	6294	22	,	,	,
cord-015021-pol2qm74	6294	23	anti	anti	NNP
cord-015021-pol2qm74	6294	24	-	-	NNP
cord-015021-pol2qm74	6294	25	IL-6	IL-6	NNP
cord-015021-pol2qm74	6294	26	)	)	-RRB-
cord-015021-pol2qm74	6294	27	,	,	,
cord-015021-pol2qm74	6294	28	some	some	DT
cord-015021-pol2qm74	6294	29	only	only	RB
cord-015021-pol2qm74	6294	30	by	by	IN
cord-015021-pol2qm74	6294	31	solid	solid	JJ
cord-015021-pol2qm74	6294	32	-	-	HYPH
cord-015021-pol2qm74	6294	33	phase	phase	NN
cord-015021-pol2qm74	6294	34	detection	detection	NN
cord-015021-pol2qm74	6294	35	systems	system	NNS
cord-015021-pol2qm74	6294	36	(	(	-LRB-
cord-015021-pol2qm74	6294	37	anti	anti	NNS
cord-015021-pol2qm74	6294	38	-	-	JJ
cord-015021-pol2qm74	6294	39	lL-8	ll-8	JJ
cord-015021-pol2qm74	6294	40	,	,	,
cord-015021-pol2qm74	6294	41	anti	anti	JJ
cord-015021-pol2qm74	6294	42	-	-	JJ
cord-015021-pol2qm74	6294	43	IFN%	ifn%	JJ
cord-015021-pol2qm74	6294	44	anti	anti	JJ
cord-015021-pol2qm74	6294	45	-	-	JJ
cord-015021-pol2qm74	6294	46	TNFc	TNFc	NNS
cord-015021-pol2qm74	6294	47	0	0	CD
cord-015021-pol2qm74	6294	48	.	.	.
cord-015021-pol2qm74	6295	1	Infusion	infusion	NN
cord-015021-pol2qm74	6295	2	of	of	IN
cord-015021-pol2qm74	6295	3	WIG	wig	NN
cord-015021-pol2qm74	6295	4	to	to	IN
cord-015021-pol2qm74	6295	5	patients	patient	NNS
cord-015021-pol2qm74	6295	6	suffering	suffer	VBG
cord-015021-pol2qm74	6295	7	from	from	IN
cord-015021-pol2qm74	6295	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6295	9	disorders	disorder	NNS
cord-015021-pol2qm74	6295	10	have	have	VBP
cord-015021-pol2qm74	6295	11	resulted	result	VBN
cord-015021-pol2qm74	6295	12	in	in	IN
cord-015021-pol2qm74	6295	13	a	a	DT
cord-015021-pol2qm74	6295	14	decrease	decrease	NN
cord-015021-pol2qm74	6295	15	in	in	IN
cord-015021-pol2qm74	6295	16	IL-6	IL-6	NNP
cord-015021-pol2qm74	6295	17	in	in	IN
cord-015021-pol2qm74	6295	18	circulation	circulation	NN
cord-015021-pol2qm74	6295	19	.	.	.
cord-015021-pol2qm74	6296	1	During	during	IN
cord-015021-pol2qm74	6296	2	infusion	infusion	NN
cord-015021-pol2qm74	6296	3	WIG	wig	NN
cord-015021-pol2qm74	6296	4	might	may	MD
cord-015021-pol2qm74	6296	5	induce	induce	VB
cord-015021-pol2qm74	6296	6	an	an	DT
cord-015021-pol2qm74	6296	7	acute	acute	JJ
cord-015021-pol2qm74	6296	8	but	but	CC
cord-015021-pol2qm74	6296	9	transient	transient	JJ
cord-015021-pol2qm74	6296	10	rise	rise	NN
cord-015021-pol2qm74	6296	11	of	of	IN
cord-015021-pol2qm74	6296	12	TNFo~	tnfo~	NN
cord-015021-pol2qm74	6296	13	,	,	,
cord-015021-pol2qm74	6296	14	IL-6	IL-6	NNP
cord-015021-pol2qm74	6296	15	,	,	,
cord-015021-pol2qm74	6296	16	and	and	CC
cord-015021-pol2qm74	6297	1	IL-8	IL-8	NNP
cord-015021-pol2qm74	6297	2	.	.	.
cord-015021-pol2qm74	6298	1	Self	self	NN
cord-015021-pol2qm74	6298	2	limitiation	limitiation	NN
cord-015021-pol2qm74	6298	3	of	of	IN
cord-015021-pol2qm74	6298	4	this	this	DT
cord-015021-pol2qm74	6298	5	process	process	NN
cord-015021-pol2qm74	6298	6	might	may	MD
cord-015021-pol2qm74	6298	7	be	be	VB
cord-015021-pol2qm74	6298	8	due	due	JJ
cord-015021-pol2qm74	6298	9	to	to	IN
cord-015021-pol2qm74	6298	10	demonstrable	demonstrable	JJ
cord-015021-pol2qm74	6298	11	instant	instant	JJ
cord-015021-pol2qm74	6298	12	release	release	NN
cord-015021-pol2qm74	6298	13	of	of	IN
cord-015021-pol2qm74	6298	14	IL-1	IL-1	NNP
cord-015021-pol2qm74	6298	15	ra	ra	NNP
cord-015021-pol2qm74	6298	16	and	and	CC
cord-015021-pol2qm74	6298	17	soluble	soluble	JJ
cord-015021-pol2qm74	6298	18	TNFo~	TNFo~	NNP
cord-015021-pol2qm74	6298	19	receptors	receptor	NNS
cord-015021-pol2qm74	6298	20	.	.	.
cord-015021-pol2qm74	6299	1	In	in	IN
cord-015021-pol2qm74	6299	2	vitro	vitro	FW
cord-015021-pol2qm74	6299	3	IVIG	IVIG	NNP
cord-015021-pol2qm74	6299	4	has	have	VBZ
cord-015021-pol2qm74	6299	5	also	also	RB
cord-015021-pol2qm74	6299	6	been	be	VBN
cord-015021-pol2qm74	6299	7	shown	show	VBN
cord-015021-pol2qm74	6299	8	to	to	TO
cord-015021-pol2qm74	6299	9	attenuate	attenuate	VB
cord-015021-pol2qm74	6299	10	complement	complement	JJ
cord-015021-pol2qm74	6299	11	activation	activation	NN
cord-015021-pol2qm74	6299	12	via	via	IN
cord-015021-pol2qm74	6299	13	the	the	DT
cord-015021-pol2qm74	6299	14	classical	classical	JJ
cord-015021-pol2qm74	6299	15	pathway	pathway	NN
cord-015021-pol2qm74	6299	16	.	.	.
cord-015021-pol2qm74	6300	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	6300	2	,	,	,
cord-015021-pol2qm74	6300	3	acid	acid	NNP
cord-015021-pol2qm74	6300	4	haemolysis	haemolysis	NN
cord-015021-pol2qm74	6300	5	of	of	IN
cord-015021-pol2qm74	6300	6	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	6300	7	in	in	IN
cord-015021-pol2qm74	6300	8	paroxysmal	paroxysmal	JJ
cord-015021-pol2qm74	6300	9	nocturnal	nocturnal	JJ
cord-015021-pol2qm74	6300	10	haemoglobinuria	haemoglobinuria	NNS
cord-015021-pol2qm74	6300	11	could	could	MD
cord-015021-pol2qm74	6300	12	partially	partially	RB
cord-015021-pol2qm74	6300	13	be	be	VB
cord-015021-pol2qm74	6300	14	prevented	prevent	VBN
cord-015021-pol2qm74	6300	15	by	by	IN
cord-015021-pol2qm74	6300	16	IVIG	IVIG	NNP
cord-015021-pol2qm74	6300	17	.	.	.
cord-015021-pol2qm74	6301	1	IVIG	IVIG	NNP
cord-015021-pol2qm74	6301	2	was	be	VBD
cord-015021-pol2qm74	6301	3	able	able	JJ
cord-015021-pol2qm74	6301	4	to	to	TO
cord-015021-pol2qm74	6301	5	attenuate	attenuate	VB
cord-015021-pol2qm74	6301	6	Forssman	Forssman	NNP
cord-015021-pol2qm74	6301	7	shock	shock	NN
cord-015021-pol2qm74	6301	8	in	in	IN
cord-015021-pol2qm74	6301	9	guinea	guinea	NN
cord-015021-pol2qm74	6301	10	pigs	pig	NNS
cord-015021-pol2qm74	6301	11	.	.	.
cord-015021-pol2qm74	6302	1	We	-PRON-	PRP
cord-015021-pol2qm74	6302	2	have	have	VBP
cord-015021-pol2qm74	6302	3	seen	see	VBN
cord-015021-pol2qm74	6302	4	a	a	DT
cord-015021-pol2qm74	6302	5	patient	patient	NN
cord-015021-pol2qm74	6302	6	with	with	IN
cord-015021-pol2qm74	6302	7	congenitally	congenitally	RB
cord-015021-pol2qm74	6302	8	elevated	elevated	JJ
cord-015021-pol2qm74	6302	9	turnover	turnover	NN
cord-015021-pol2qm74	6302	10	of	of	IN
cord-015021-pol2qm74	6302	11	alternative	alternative	JJ
cord-015021-pol2qm74	6302	12	pathway	pathway	NN
cord-015021-pol2qm74	6302	13	of	of	IN
cord-015021-pol2qm74	6302	14	complement	complement	NN
cord-015021-pol2qm74	6302	15	who	who	WP
cord-015021-pol2qm74	6302	16	repeatedly	repeatedly	RB
cord-015021-pol2qm74	6302	17	showed	show	VBD
cord-015021-pol2qm74	6302	18	an	an	DT
cord-015021-pol2qm74	6302	19	increase	increase	NN
cord-015021-pol2qm74	6302	20	of	of	IN
cord-015021-pol2qm74	6302	21	haemolytic	haemolytic	JJ
cord-015021-pol2qm74	6302	22	titres	titre	NNS
cord-015021-pol2qm74	6302	23	after	after	IN
cord-015021-pol2qm74	6302	24	administration	administration	NN
cord-015021-pol2qm74	6302	25	of	of	IN
cord-015021-pol2qm74	6302	26	IVIG	IVIG	NNP
cord-015021-pol2qm74	6302	27	.	.	.
cord-015021-pol2qm74	6303	1	Thus	thus	RB
cord-015021-pol2qm74	6303	2	,	,	,
cord-015021-pol2qm74	6303	3	WIGs	wig	NNS
cord-015021-pol2qm74	6303	4	apparently	apparently	RB
cord-015021-pol2qm74	6303	5	have	have	VBP
cord-015021-pol2qm74	6303	6	multiple	multiple	JJ
cord-015021-pol2qm74	6303	7	potencies	potency	NNS
cord-015021-pol2qm74	6303	8	including	include	VBG
cord-015021-pol2qm74	6303	9	attenuation	attenuation	NN
cord-015021-pol2qm74	6303	10	of	of	IN
cord-015021-pol2qm74	6303	11	soluble	soluble	JJ
cord-015021-pol2qm74	6303	12	mediators	mediator	NNS
cord-015021-pol2qm74	6303	13	of	of	IN
cord-015021-pol2qm74	6303	14	inflammation	inflammation	NN
cord-015021-pol2qm74	6303	15	and	and	CC
cord-015021-pol2qm74	6303	16	might	may	MD
cord-015021-pol2qm74	6303	17	therefore	therefore	RB
cord-015021-pol2qm74	6303	18	be	be	VB
cord-015021-pol2qm74	6303	19	of	of	IN
cord-015021-pol2qm74	6303	20	benefit	benefit	NN
cord-015021-pol2qm74	6303	21	in	in	IN
cord-015021-pol2qm74	6303	22	trauma	trauma	NN
cord-015021-pol2qm74	6303	23	,	,	,
cord-015021-pol2qm74	6303	24	shock	shock	NN
cord-015021-pol2qm74	6303	25	,	,	,
cord-015021-pol2qm74	6303	26	and	and	CC
cord-015021-pol2qm74	6303	27	sepsis	sepsis	NN
cord-015021-pol2qm74	6303	28	.	.	.
cord-015021-pol2qm74	6304	1	Significance	significance	NN
cord-015021-pol2qm74	6304	2	of	of	IN
cord-015021-pol2qm74	6304	3	sinusoidal	sinusoidal	JJ
cord-015021-pol2qm74	6304	4	liuing	liuing	NN
cord-015021-pol2qm74	6304	5	cells	cell	NNS
cord-015021-pol2qm74	6304	6	and	and	CC
cord-015021-pol2qm74	6304	7	of	of	IN
cord-015021-pol2qm74	6304	8	humoral	humoral	JJ
cord-015021-pol2qm74	6304	9	factors	factor	NNS
cord-015021-pol2qm74	6304	10	on	on	IN
cord-015021-pol2qm74	6304	11	hepatic	hepatic	JJ
cord-015021-pol2qm74	6304	12	function	function	NN
cord-015021-pol2qm74	6304	13	following	follow	VBG
cord-015021-pol2qm74	6304	14	sepsis	sepsis	NN
cord-015021-pol2qm74	6304	15	and	and	CC
cord-015021-pol2qm74	6304	16	major	major	JJ
cord-015021-pol2qm74	6304	17	surgery	surgery	NN
cord-015021-pol2qm74	6305	1	Hirata	Hirata	NNP
cord-015021-pol2qm74	6305	2	K	K	NNP
cord-015021-pol2qm74	6305	3	,	,	,
cord-015021-pol2qm74	6305	4	Katsuramaki	Katsuramaki	NNP
cord-015021-pol2qm74	6305	5	T	T	NNP
cord-015021-pol2qm74	6305	6	,	,	,
cord-015021-pol2qm74	6305	7	Yamaguchi	Yamaguchi	NNP
cord-015021-pol2qm74	6305	8	H	H	NNP
cord-015021-pol2qm74	6305	9	,	,	,
cord-015021-pol2qm74	6305	10	Mukaiya	Mukaiya	NNP
cord-015021-pol2qm74	6305	11	M	M	NNP
cord-015021-pol2qm74	6305	12	,	,	,
cord-015021-pol2qm74	6305	13	Yamashiro	Yamashiro	NNP
cord-015021-pol2qm74	6305	14	K.	K.	NNP
cord-015021-pol2qm74	6305	15	Regeneration	regeneration	NN
cord-015021-pol2qm74	6305	16	of	of	IN
cord-015021-pol2qm74	6305	17	the	the	DT
cord-015021-pol2qm74	6305	18	liver	liver	NN
cord-015021-pol2qm74	6305	19	after	after	IN
cord-015021-pol2qm74	6305	20	hepatic	hepatic	JJ
cord-015021-pol2qm74	6305	21	necrosis	necrosis	NN
cord-015021-pol2qm74	6305	22	or	or	CC
cord-015021-pol2qm74	6305	23	partial	partial	JJ
cord-015021-pol2qm74	6305	24	removal	removal	NN
cord-015021-pol2qm74	6305	25	has	have	VBZ
cord-015021-pol2qm74	6305	26	been	be	VBN
cord-015021-pol2qm74	6305	27	extensively	extensively	RB
cord-015021-pol2qm74	6305	28	studied	study	VBN
cord-015021-pol2qm74	6305	29	,	,	,
cord-015021-pol2qm74	6305	30	but	but	CC
cord-015021-pol2qm74	6305	31	uncontrolled	uncontrolled	JJ
cord-015021-pol2qm74	6305	32	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6305	33	to	to	IN
cord-015021-pol2qm74	6305	34	irreversible	irreversible	JJ
cord-015021-pol2qm74	6305	35	hepatic	hepatic	JJ
cord-015021-pol2qm74	6305	36	failure	failure	NN
cord-015021-pol2qm74	6305	37	following	follow	VBG
cord-015021-pol2qm74	6305	38	sepsis	sepsis	NN
cord-015021-pol2qm74	6305	39	or	or	CC
cord-015021-pol2qm74	6305	40	major	major	JJ
cord-015021-pol2qm74	6305	41	surgery	surgery	NN
cord-015021-pol2qm74	6305	42	of	of	IN
cord-015021-pol2qm74	6305	43	liver	liver	NN
cord-015021-pol2qm74	6305	44	or	or	CC
cord-015021-pol2qm74	6305	45	with	with	IN
cord-015021-pol2qm74	6305	46	hepatic	hepatic	JJ
cord-015021-pol2qm74	6305	47	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6305	48	have	have	VBP
cord-015021-pol2qm74	6305	49	so	so	RB
cord-015021-pol2qm74	6305	50	far	far	RB
cord-015021-pol2qm74	6305	51	not	not	RB
cord-015021-pol2qm74	6305	52	been	be	VBN
cord-015021-pol2qm74	6305	53	well	well	RB
cord-015021-pol2qm74	6305	54	documented	document	VBN
cord-015021-pol2qm74	6305	55	.	.	.
cord-015021-pol2qm74	6306	1	We	-PRON-	PRP
cord-015021-pol2qm74	6306	2	suggested	suggest	VBD
cord-015021-pol2qm74	6306	3	the	the	DT
cord-015021-pol2qm74	6306	4	importance	importance	NN
cord-015021-pol2qm74	6306	5	of	of	IN
cord-015021-pol2qm74	6306	6	the	the	DT
cord-015021-pol2qm74	6306	7	intrasinusoidal	intrasinusoidal	JJ
cord-015021-pol2qm74	6306	8	aggregation	aggregation	NN
cord-015021-pol2qm74	6306	9	between	between	IN
cord-015021-pol2qm74	6306	10	sinusoidal	sinusoidal	JJ
cord-015021-pol2qm74	6306	11	lining	lining	NN
cord-015021-pol2qm74	6306	12	cells	cell	NNS
cord-015021-pol2qm74	6306	13	and	and	CC
cord-015021-pol2qm74	6306	14	intrasinusoidal	intrasinusoidal	NNP
cord-015021-pol2qm74	6306	15	running	run	VBG
cord-015021-pol2qm74	6306	16	ceils	ceils	NNP
cord-015021-pol2qm74	6306	17	in	in	IN
cord-015021-pol2qm74	6306	18	the	the	DT
cord-015021-pol2qm74	6306	19	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6306	20	of	of	IN
cord-015021-pol2qm74	6306	21	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	6306	22	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6306	23	.	.	.
cord-015021-pol2qm74	6307	1	Thus	thus	RB
cord-015021-pol2qm74	6307	2	,	,	,
cord-015021-pol2qm74	6307	3	the	the	DT
cord-015021-pol2qm74	6307	4	purposes	purpose	NNS
cord-015021-pol2qm74	6307	5	of	of	IN
cord-015021-pol2qm74	6307	6	this	this	DT
cord-015021-pol2qm74	6307	7	study	study	NN
cord-015021-pol2qm74	6307	8	was	be	VBD
cord-015021-pol2qm74	6307	9	to	to	TO
cord-015021-pol2qm74	6307	10	investigate	investigate	VB
cord-015021-pol2qm74	6307	11	the	the	DT
cord-015021-pol2qm74	6307	12	changes	change	NNS
cord-015021-pol2qm74	6307	13	in	in	IN
cord-015021-pol2qm74	6307	14	each	each	DT
cord-015021-pol2qm74	6307	15	sinusoidal	sinusoidal	JJ
cord-015021-pol2qm74	6307	16	lining	lining	NN
cord-015021-pol2qm74	6307	17	cell	cell	NN
cord-015021-pol2qm74	6307	18	during	during	IN
cord-015021-pol2qm74	6307	19	this	this	DT
cord-015021-pol2qm74	6307	20	process	process	NN
cord-015021-pol2qm74	6307	21	and	and	CC
cord-015021-pol2qm74	6307	22	the	the	DT
cord-015021-pol2qm74	6307	23	effect	effect	NN
cord-015021-pol2qm74	6307	24	of	of	IN
cord-015021-pol2qm74	6307	25	cytokine	cytokine	NN
cord-015021-pol2qm74	6307	26	on	on	IN
cord-015021-pol2qm74	6307	27	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	6307	28	under	under	IN
cord-015021-pol2qm74	6307	29	various	various	JJ
cord-015021-pol2qm74	6307	30	oxygenation	oxygenation	NN
cord-015021-pol2qm74	6307	31	.	.	.
cord-015021-pol2qm74	6308	1	[	[	-LRB-
cord-015021-pol2qm74	6308	2	Materials	material	NNS
cord-015021-pol2qm74	6308	3	and	and	CC
cord-015021-pol2qm74	6308	4	Methods	Methods	NNPS
cord-015021-pol2qm74	6308	5	]	]	-RRB-
cord-015021-pol2qm74	6308	6	(	(	-LRB-
cord-015021-pol2qm74	6308	7	1	1	LS
cord-015021-pol2qm74	6308	8	)	)	-RRB-
cord-015021-pol2qm74	6308	9	Clinical	clinical	JJ
cord-015021-pol2qm74	6308	10	study	study	NN
cord-015021-pol2qm74	6308	11	:	:	:
cord-015021-pol2qm74	6309	1	Thirty	thirty	CD
cord-015021-pol2qm74	6309	2	two	two	CD
cord-015021-pol2qm74	6309	3	patients	patient	NNS
cord-015021-pol2qm74	6309	4	with	with	IN
cord-015021-pol2qm74	6309	5	histologically	histologically	RB
cord-015021-pol2qm74	6309	6	proved	prove	VBN
cord-015021-pol2qm74	6309	7	malignant	malignant	JJ
cord-015021-pol2qm74	6309	8	tumor	tumor	NN
cord-015021-pol2qm74	6309	9	underwent	undergo	VBD
cord-015021-pol2qm74	6309	10	major	major	JJ
cord-015021-pol2qm74	6309	11	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	6309	12	were	be	VBD
cord-015021-pol2qm74	6309	13	devided	devide	VBN
cord-015021-pol2qm74	6309	14	in	in	IN
cord-015021-pol2qm74	6309	15	two	two	CD
cord-015021-pol2qm74	6309	16	groups	group	NNS
cord-015021-pol2qm74	6309	17	,	,	,
cord-015021-pol2qm74	6309	18	i_e	i_e	NNP
cord-015021-pol2qm74	6309	19	.	.	.
cord-015021-pol2qm74	6310	1	the	the	DT
cord-015021-pol2qm74	6310	2	cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	6310	3	liver	liver	NN
cord-015021-pol2qm74	6310	4	group	group	NN
cord-015021-pol2qm74	6310	5	and	and	CC
cord-015021-pol2qm74	6310	6	the	the	DT
cord-015021-pol2qm74	6310	7	non	non	JJ
cord-015021-pol2qm74	6310	8	-	-	JJ
cord-015021-pol2qm74	6310	9	cirrhotic	cirrhotic	JJ
cord-015021-pol2qm74	6310	10	[	[	-LRB-
cord-015021-pol2qm74	6310	11	Aver	Aver	NNP
cord-015021-pol2qm74	6310	12	group	group	NN
cord-015021-pol2qm74	6310	13	.	.	.
cord-015021-pol2qm74	6311	1	Most	Most	JJS
cord-015021-pol2qm74	6311	2	of	of	IN
cord-015021-pol2qm74	6311	3	the	the	DT
cord-015021-pol2qm74	6311	4	former	former	JJ
cord-015021-pol2qm74	6311	5	were	be	VBD
cord-015021-pol2qm74	6311	6	the	the	DT
cord-015021-pol2qm74	6311	7	patients	patient	NNS
cord-015021-pol2qm74	6311	8	with	with	IN
cord-015021-pol2qm74	6311	9	hepatocellular	hepatocellular	JJ
cord-015021-pol2qm74	6311	10	carcinoma	carcinoma	NN
cord-015021-pol2qm74	6311	11	and	and	CC
cord-015021-pol2qm74	6311	12	most	most	JJS
cord-015021-pol2qm74	6311	13	of	of	IN
cord-015021-pol2qm74	6311	14	the	the	DT
cord-015021-pol2qm74	6311	15	latter	latter	JJ
cord-015021-pol2qm74	6311	16	were	be	VBD
cord-015021-pol2qm74	6311	17	the	the	DT
cord-015021-pol2qm74	6311	18	patients	patient	NNS
cord-015021-pol2qm74	6311	19	with	with	IN
cord-015021-pol2qm74	6311	20	metastatic	metastatic	JJ
cord-015021-pol2qm74	6311	21	carcinoma	carcinoma	NN
cord-015021-pol2qm74	6311	22	of	of	IN
cord-015021-pol2qm74	6311	23	colorectal	colorectal	JJ
cord-015021-pol2qm74	6311	24	cancer	cancer	NN
cord-015021-pol2qm74	6311	25	.	.	.
cord-015021-pol2qm74	6312	1	Five	five	CD
cord-015021-pol2qm74	6312	2	patients	patient	NNS
cord-015021-pol2qm74	6312	3	were	be	VBD
cord-015021-pol2qm74	6312	4	complicated	complicated	JJ
cord-015021-pol2qm74	6312	5	septic	septic	JJ
cord-015021-pol2qm74	6312	6	conditions	condition	NNS
cord-015021-pol2qm74	6312	7	with	with	IN
cord-015021-pol2qm74	6312	8	hepatic	hepatic	JJ
cord-015021-pol2qm74	6312	9	failure	failure	NN
cord-015021-pol2qm74	6312	10	.	.	.
cord-015021-pol2qm74	6313	1	Following	follow	VBG
cord-015021-pol2qm74	6313	2	operation	operation	NN
cord-015021-pol2qm74	6313	3	in	in	IN
cord-015021-pol2qm74	6313	4	each	each	DT
cord-015021-pol2qm74	6313	5	patient	patient	NN
cord-015021-pol2qm74	6313	6	,	,	,
cord-015021-pol2qm74	6313	7	a	a	DT
cord-015021-pol2qm74	6313	8	verous	verous	JJ
cord-015021-pol2qm74	6313	9	blood	blood	NN
cord-015021-pol2qm74	6313	10	sample	sample	NN
cord-015021-pol2qm74	6313	11	was	be	VBD
cord-015021-pol2qm74	6313	12	taken	take	VBN
cord-015021-pol2qm74	6313	13	for	for	IN
cord-015021-pol2qm74	6313	14	measurement	measurement	NN
cord-015021-pol2qm74	6313	15	of	of	IN
cord-015021-pol2qm74	6313	16	serum	serum	NN
cord-015021-pol2qm74	6313	17	IL-1	IL-1	NNP
cord-015021-pol2qm74	6313	18	,	,	,
cord-015021-pol2qm74	6313	19	IL-6	IL-6	NNP
cord-015021-pol2qm74	6313	20	,	,	,
cord-015021-pol2qm74	6313	21	TNF	TNF	NNP
cord-015021-pol2qm74	6313	22	and	and	CC
cord-015021-pol2qm74	6313	23	C	C	NNP
cord-015021-pol2qm74	6313	24	-	-	HYPH
cord-015021-pol2qm74	6313	25	reactive	reactive	JJ
cord-015021-pol2qm74	6313	26	protein	protein	NN
cord-015021-pol2qm74	6313	27	concentration	concentration	NN
cord-015021-pol2qm74	6313	28	.	.	.
cord-015021-pol2qm74	6314	1	And	and	CC
cord-015021-pol2qm74	6314	2	hepatic	hepatic	JJ
cord-015021-pol2qm74	6314	3	biopsies	biopsy	NNS
cord-015021-pol2qm74	6314	4	were	be	VBD
cord-015021-pol2qm74	6314	5	sometimes	sometimes	RB
cord-015021-pol2qm74	6314	6	undergone	undergo	VBN
cord-015021-pol2qm74	6314	7	in	in	IN
cord-015021-pol2qm74	6314	8	patients	patient	NNS
cord-015021-pol2qm74	6314	9	with	with	IN
cord-015021-pol2qm74	6314	10	anomalous	anomalous	JJ
cord-015021-pol2qm74	6314	11	hepatic	hepatic	JJ
cord-015021-pol2qm74	6314	12	function	function	NN
cord-015021-pol2qm74	6314	13	.	.	.
cord-015021-pol2qm74	6315	1	(	(	-LRB-
cord-015021-pol2qm74	6315	2	2	2	LS
cord-015021-pol2qm74	6315	3	)	)	-RRB-
cord-015021-pol2qm74	6315	4	Experimental	experimental	JJ
cord-015021-pol2qm74	6315	5	study	study	NN
cord-015021-pol2qm74	6315	6	:	:	:
cord-015021-pol2qm74	6315	7	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	6315	8	ceils	ceil	NNS
cord-015021-pol2qm74	6315	9	,	,	,
cord-015021-pol2qm74	6315	10	sinsoidal	sinsoidal	JJ
cord-015021-pol2qm74	6315	11	endothelial	endothelial	JJ
cord-015021-pol2qm74	6315	12	cells	cell	NNS
cord-015021-pol2qm74	6315	13	and	and	CC
cord-015021-pol2qm74	6315	14	hepatocytes	hepatocyte	NNS
cord-015021-pol2qm74	6315	15	were	be	VBD
cord-015021-pol2qm74	6315	16	separated	separate	VBN
cord-015021-pol2qm74	6315	17	from	from	IN
cord-015021-pol2qm74	6315	18	mouse	mouse	NN
cord-015021-pol2qm74	6315	19	(	(	-LRB-
cord-015021-pol2qm74	6315	20	C3HHeN	C3HHeN	NNP
cord-015021-pol2qm74	6315	21	)	)	-RRB-
cord-015021-pol2qm74	6315	22	liver	liver	NN
cord-015021-pol2qm74	6315	23	.	.	.
cord-015021-pol2qm74	6316	1	And	and	CC
cord-015021-pol2qm74	6316	2	also	also	RB
cord-015021-pol2qm74	6316	3	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	6316	4	cells	cell	NNS
cord-015021-pol2qm74	6316	5	and	and	CC
cord-015021-pol2qm74	6316	6	platelets	platelet	NNS
cord-015021-pol2qm74	6316	7	were	be	VBD
cord-015021-pol2qm74	6316	8	purified	purify	VBN
cord-015021-pol2qm74	6316	9	from	from	IN
cord-015021-pol2qm74	6316	10	blood	blood	NN
cord-015021-pol2qm74	6316	11	and	and	CC
cord-015021-pol2qm74	6316	12	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6316	13	macrophages	macrophage	NNS
cord-015021-pol2qm74	6316	14	were	be	VBD
cord-015021-pol2qm74	6316	15	from	from	IN
cord-015021-pol2qm74	6316	16	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6316	17	cavity	cavity	NN
cord-015021-pol2qm74	6316	18	of	of	IN
cord-015021-pol2qm74	6316	19	mouse	mouse	NN
cord-015021-pol2qm74	6316	20	.	.	.
cord-015021-pol2qm74	6317	1	Co	Co	NNS
cord-015021-pol2qm74	6317	2	-	-	NNS
cord-015021-pol2qm74	6317	3	cultures	culture	NNS
cord-015021-pol2qm74	6317	4	between	between	IN
cord-015021-pol2qm74	6317	5	or	or	CC
cord-015021-pol2qm74	6317	6	among	among	IN
cord-015021-pol2qm74	6317	7	these	these	DT
cord-015021-pol2qm74	6317	8	cells	cell	NNS
cord-015021-pol2qm74	6317	9	with	with	IN
cord-015021-pol2qm74	6317	10	Iipopolysaccharide	Iipopolysaccharide	NNP
cord-015021-pol2qm74	6317	11	were	be	VBD
cord-015021-pol2qm74	6317	12	performed	perform	VBN
cord-015021-pol2qm74	6317	13	.	.	.
cord-015021-pol2qm74	6318	1	Cytokine	cytokine	NN
cord-015021-pol2qm74	6318	2	concentrations	concentration	NNS
cord-015021-pol2qm74	6318	3	in	in	IN
cord-015021-pol2qm74	6318	4	media	medium	NNS
cord-015021-pol2qm74	6318	5	and	and	CC
cord-015021-pol2qm74	6318	6	hepatocytic	hepatocytic	JJ
cord-015021-pol2qm74	6318	7	function	function	NN
cord-015021-pol2qm74	6318	8	were	be	VBD
cord-015021-pol2qm74	6318	9	compared	compare	VBN
cord-015021-pol2qm74	6318	10	.	.	.
cord-015021-pol2qm74	6319	1	[	[	-LRB-
cord-015021-pol2qm74	6319	2	Results	result	NNS
cord-015021-pol2qm74	6319	3	and	and	CC
cord-015021-pol2qm74	6319	4	Conclusion	conclusion	NN
cord-015021-pol2qm74	6319	5	]	]	-RRB-
cord-015021-pol2qm74	6319	6	Our	-PRON-	PRP$
cord-015021-pol2qm74	6319	7	findings	finding	NNS
cord-015021-pol2qm74	6319	8	in	in	IN
cord-015021-pol2qm74	6319	9	above	above	IN
cord-015021-pol2qm74	6319	10	experiments	experiment	NNS
cord-015021-pol2qm74	6319	11	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	6319	12	the	the	DT
cord-015021-pol2qm74	6319	13	cleanly	cleanly	RB
cord-015021-pol2qm74	6319	14	different	different	JJ
cord-015021-pol2qm74	6319	15	concept	concept	NN
cord-015021-pol2qm74	6319	16	for	for	IN
cord-015021-pol2qm74	6319	17	the	the	DT
cord-015021-pol2qm74	6319	18	mechanism	mechanism	NN
cord-015021-pol2qm74	6319	19	of	of	IN
cord-015021-pol2qm74	6319	20	hepatocyte	hepatocyte	NN
cord-015021-pol2qm74	6319	21	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6319	22	following	follow	VBG
cord-015021-pol2qm74	6319	23	sepsis	sepsis	NN
cord-015021-pol2qm74	6319	24	or	or	CC
cord-015021-pol2qm74	6319	25	major	major	JJ
cord-015021-pol2qm74	6319	26	surgery	surgery	NN
cord-015021-pol2qm74	6319	27	.	.	.
cord-015021-pol2qm74	6320	1	Namely	namely	RB
cord-015021-pol2qm74	6320	2	,	,	,
cord-015021-pol2qm74	6320	3	the	the	DT
cord-015021-pol2qm74	6320	4	effect	effect	NN
cord-015021-pol2qm74	6320	5	of	of	IN
cord-015021-pol2qm74	6320	6	hepatoeytie	hepatoeytie	NN
cord-015021-pol2qm74	6320	7	function	function	NN
cord-015021-pol2qm74	6320	8	by	by	IN
cord-015021-pol2qm74	6320	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	6320	10	or	or	CC
cord-015021-pol2qm74	6320	11	superioxide	superioxide	NN
cord-015021-pol2qm74	6320	12	were	be	VBD
cord-015021-pol2qm74	6320	13	significantly	significantly	RB
cord-015021-pol2qm74	6320	14	affected	affect	VBN
cord-015021-pol2qm74	6320	15	under	under	IN
cord-015021-pol2qm74	6320	16	low	low	JJ
cord-015021-pol2qm74	6320	17	oxygenation	oxygenation	NN
cord-015021-pol2qm74	6320	18	,	,	,
cord-015021-pol2qm74	6320	19	but	but	CC
cord-015021-pol2qm74	6320	20	not	not	RB
cord-015021-pol2qm74	6320	21	significant	significant	JJ
cord-015021-pol2qm74	6320	22	under	under	IN
cord-015021-pol2qm74	6320	23	good	good	JJ
cord-015021-pol2qm74	6320	24	oxygenation	oxygenation	NN
cord-015021-pol2qm74	6320	25	.	.	.
cord-015021-pol2qm74	6321	1	Hirata	Hirata	NNP
cord-015021-pol2qm74	6321	2	M.D.,Nishi	M.D.,Nishi	NNP
cord-015021-pol2qm74	6322	1	17,Hokkaido	17,hokkaido	CD
cord-015021-pol2qm74	6322	2	,	,	,
cord-015021-pol2qm74	6322	3	Japan	Japan	NNP
cord-015021-pol2qm74	6322	4	$	$	$
cord-015021-pol2qm74	6322	5	120	120	CD
cord-015021-pol2qm74	6322	6	470	470	CD
cord-015021-pol2qm74	6322	7	immune	immune	JJ
cord-015021-pol2qm74	6322	8	Complexes	complex	NNS
cord-015021-pol2qm74	6322	9	as	as	IN
cord-015021-pol2qm74	6322	10	.Mediators	.mediator	NNS
cord-015021-pol2qm74	6322	11	of	of	IN
cord-015021-pol2qm74	6322	12	Sepsis	Sepsis	NNP
cord-015021-pol2qm74	6322	13	and	and	CC
cord-015021-pol2qm74	6322	14	Immune	Immune	NNP
cord-015021-pol2qm74	6322	15	Dyafumcffon	Dyafumcffon	NNP
cord-015021-pol2qm74	6323	1	laa	laa	NNP
cord-015021-pol2qm74	6323	2	K	K	NNP
cord-015021-pol2qm74	6323	3	Horn	Horn	NNP
cord-015021-pol2qm74	6323	4	,	,	,
cord-015021-pol2qm74	6323	5	Chxistof	Chxistof	NNP
cord-015021-pol2qm74	6323	6	Birkenmaier	Birkenmaier	NNP
cord-015021-pol2qm74	6323	7	,	,	,
cord-015021-pol2qm74	6323	8	and	and	CC
cord-015021-pol2qm74	6323	9	Greg	Greg	NNP
cord-015021-pol2qm74	6323	10	H2mon	H2mon	NNP
cord-015021-pol2qm74	6323	11	Departmen~	departmen~	VBP
cord-015021-pol2qm74	6323	12	of	of	IN
cord-015021-pol2qm74	6323	13	Surgery	surgery	NN
cord-015021-pol2qm74	6323	14	,	,	,
cord-015021-pol2qm74	6323	15	San	San	NNP
cord-015021-pol2qm74	6323	16	Frandsco	Frandsco	NNP
cord-015021-pol2qm74	6323	17	General	General	NNP
cord-015021-pol2qm74	6323	18	Hospital	Hospital	NNP
cord-015021-pol2qm74	6323	19	,	,	,
cord-015021-pol2qm74	6323	20	UrdversR	urdversr	JJ
cord-015021-pol2qm74	6323	21	3	3	CD
cord-015021-pol2qm74	6323	22	,	,	,
cord-015021-pol2qm74	6323	23	of	of	IN
cord-015021-pol2qm74	6323	24	Calif(~rrda	Calif(~rrda	NNP
cord-015021-pol2qm74	6323	25	,	,	,
cord-015021-pol2qm74	6323	26	San	San	NNP
cord-015021-pol2qm74	6323	27	Frandsco	Frandsco	NNP
cord-015021-pol2qm74	6323	28	.	.	.
cord-015021-pol2qm74	6324	1	Immune	immune	JJ
cord-015021-pol2qm74	6324	2	complexes	complex	NNS
cord-015021-pol2qm74	6324	3	(	(	-LRB-
cord-015021-pol2qm74	6325	1	IC	IC	NNP
cord-015021-pol2qm74	6325	2	)	)	-RRB-
cord-015021-pol2qm74	6325	3	a;:e	a;:e	NFP
cord-015021-pol2qm74	6325	4	commonly	commonly	RB
cord-015021-pol2qm74	6325	5	found	find	VBD
cord-015021-pol2qm74	6325	6	circulating	circulate	VBG
cord-015021-pol2qm74	6325	7	in	in	IN
cord-015021-pol2qm74	6325	8	parians	parian	NNS
cord-015021-pol2qm74	6325	9	during	during	IN
cord-015021-pol2qm74	6325	10	infection	infection	NN
cord-015021-pol2qm74	6325	11	and	and	CC
cord-015021-pol2qm74	6325	12	sepsis	sepsis	NN
cord-015021-pol2qm74	6325	13	;	;	:
cord-015021-pol2qm74	6325	14	and	and	CC
cord-015021-pol2qm74	6325	15	following	follow	VBG
cord-015021-pol2qm74	6325	16	traumm	traumm	NNP
cord-015021-pol2qm74	6325	17	,	,	,
cord-015021-pol2qm74	6325	18	bums	bum	NNS
cord-015021-pol2qm74	6325	19	,	,	,
cord-015021-pol2qm74	6325	20	and	and	CC
cord-015021-pol2qm74	6325	21	massive	massive	JJ
cord-015021-pol2qm74	6325	22	l	l	NN
cord-015021-pol2qm74	6325	23	~	~	CD
cord-015021-pol2qm74	6325	24	ensfusion	ensfusion	NN
cord-015021-pol2qm74	6325	25	.	.	.
cord-015021-pol2qm74	6326	1	Clearance	clearance	NN
cord-015021-pol2qm74	6326	2	of	of	IN
cord-015021-pol2qm74	6326	3	1C	1c	NN
cord-015021-pol2qm74	6326	4	occurs	occur	VBZ
cord-015021-pol2qm74	6326	5	by	by	IN
cord-015021-pol2qm74	6326	6	phago~'Tmsis	phago~'Tmsis	NNP
cord-015021-pol2qm74	6326	7	of	of	IN
cord-015021-pol2qm74	6326	8	esll	esll	NNP
cord-015021-pol2qm74	6326	9	-	-	HYPH
cord-015021-pol2qm74	6326	10	bou_nd	bou_nd	NNP
cord-015021-pol2qm74	6326	11	or	or	CC
cord-015021-pol2qm74	6326	12	opsonized	opsonize	VBN
cord-015021-pol2qm74	6326	13	p	p	NN
cord-015021-pol2qm74	6326	14	~	~	CD
cord-015021-pol2qm74	6326	15	tlcles	tlcle	NNS
cord-015021-pol2qm74	6326	16	.	.	.
cord-015021-pol2qm74	6327	1	Monocyte	Monocyte	NNP
cord-015021-pol2qm74	6327	2	activation	activation	NN
cord-015021-pol2qm74	6327	3	du	du	NNP
cord-015021-pol2qm74	6328	1	~Jng	~Jng	NNP
cord-015021-pol2qm74	6328	2	phmgocytos	phmgocytos	NNP
cord-015021-pol2qm74	6328	3	/	/	SYM
cord-015021-pol2qm74	6328	4	s	s	PRP
cord-015021-pol2qm74	6328	5	could	could	MD
cord-015021-pol2qm74	6328	6	lead	lead	VB
cord-015021-pol2qm74	6328	7	~o	~o	NNP
cord-015021-pol2qm74	6328	8	release	release	NN
cord-015021-pol2qm74	6328	9	of	of	IN
cord-015021-pol2qm74	6328	10	cytokilIes	cytokilie	NNS
cord-015021-pol2qm74	6328	11	ieletexiot~	ieletexiot~	NNP
cord-015021-pol2qm74	6328	12	to	to	IN
cord-015021-pol2qm74	6328	13	the	the	DT
cord-015021-pol2qm74	6328	14	hosh	hosh	NN
cord-015021-pol2qm74	6329	1	To	to	TO
cord-015021-pol2qm74	6329	2	examine	examine	VB
cord-015021-pol2qm74	6329	3	tb	tb	NNP
cord-015021-pol2qm74	6329	4	/	/	SYM
cord-015021-pol2qm74	6329	5	s	s	POS
cord-015021-pol2qm74	6329	6	phenomenon	phenomenon	NN
cord-015021-pol2qm74	6329	7	,	,	,
cord-015021-pol2qm74	6329	8	we	-PRON-	PRP
cord-015021-pol2qm74	6329	9	formed	form	VBD
cord-015021-pol2qm74	6329	10	insoluble	insoluble	JJ
cord-015021-pol2qm74	6329	11	IC	ic	NN
cord-015021-pol2qm74	6329	12	by	by	IN
cord-015021-pol2qm74	6329	13	precipitating	precipitate	VBG
cord-015021-pol2qm74	6329	14	Iow	Iow	NNP
cord-015021-pol2qm74	6329	15	-	-	HYPH
cord-015021-pol2qm74	6329	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6329	17	bovine	bovine	NN
cord-015021-pol2qm74	6329	18	serun~	serun~	NN
cord-015021-pol2qm74	6329	19	albumin	albumin	NN
cord-015021-pol2qm74	6329	20	(	(	-LRB-
cord-015021-pol2qm74	6329	21	BSA	BSA	NNP
cord-015021-pol2qm74	6329	22	)	)	-RRB-
cord-015021-pol2qm74	6329	23	with	with	IN
cord-015021-pol2qm74	6329	24	rabbit	rabbit	NN
cord-015021-pol2qm74	6329	25	ant/-BSA	ant/-bsa	NN
cord-015021-pol2qm74	6330	1	IgG.	IgG.	NNP
cord-015021-pol2qm74	6331	1	We	-PRON-	PRP
cord-015021-pol2qm74	6331	2	have	have	VBP
cord-015021-pol2qm74	6331	3	~town	~town	XX
cord-015021-pol2qm74	6331	4	that	that	WDT
cord-015021-pol2qm74	6331	5	these	these	DT
cord-015021-pol2qm74	6331	6	IC	IC	NNP
cord-015021-pol2qm74	6331	7	are	be	VBP
cord-015021-pol2qm74	6331	8	ingested	ingest	VBN
cord-015021-pol2qm74	6331	9	by	by	IN
cord-015021-pol2qm74	6331	10	monocytes	monocyte	NNS
cord-015021-pol2qm74	6331	11	and	and	CC
cord-015021-pol2qm74	6331	12	concomitantly	concomitantly	RB
cord-015021-pol2qm74	6331	13	stimv	stimv	NNP
cord-015021-pol2qm74	6331	14	/	/	SYM
cord-015021-pol2qm74	6331	15	ate	eat	VBD
cord-015021-pol2qm74	6331	16	re	re	NNP
cord-015021-pol2qm74	6331	17	~	~	CD
cord-015021-pol2qm74	6331	18	pizatory	pizatory	NNP
cord-015021-pol2qm74	6331	19	bu	bu	NNP
cord-015021-pol2qm74	6331	20	~	~	NNP
cord-015021-pol2qm74	6331	21	t	t	XX
cord-015021-pol2qm74	6331	22	activity	activity	NN
cord-015021-pol2qm74	6331	23	measuxed	measuxed	NNP
cord-015021-pol2qm74	6331	24	by	by	IN
cord-015021-pol2qm74	6331	25	assay	assay	NN
cord-015021-pol2qm74	6331	26	of	of	IN
cord-015021-pol2qm74	6331	27	in%racellul~	in%racellul~	NNP
cord-015021-pol2qm74	6331	28	peroxldaffon	peroxldaffon	JJ
cord-015021-pol2qm74	6331	29	.	.	.
cord-015021-pol2qm74	6332	1	We	-PRON-	PRP
cord-015021-pol2qm74	6332	2	have	have	VBP
cord-015021-pol2qm74	6332	3	shown	show	VBN
cord-015021-pol2qm74	6332	4	that	that	IN
cord-015021-pol2qm74	6332	5	IC	IC	NNP
cord-015021-pol2qm74	6332	6	ingesffon	ingesffon	NNP
cord-015021-pol2qm74	6332	7	produces	produce	VBZ
cord-015021-pol2qm74	6332	8	signLqcant	signlqcant	JJ
cord-015021-pol2qm74	6332	9	el	el	NNP
cord-015021-pol2qm74	6332	10	,	,	,
cord-015021-pol2qm74	6332	11	era	era	NN
cord-015021-pol2qm74	6332	12	,	,	,
cord-015021-pol2qm74	6332	13	lore	lore	NN
cord-015021-pol2qm74	6332	14	in	in	IN
cord-015021-pol2qm74	6332	15	the	the	DT
cord-015021-pol2qm74	6332	16	monoey	monoey	NN
cord-015021-pol2qm74	6332	17	~	~	NFP
cord-015021-pol2qm74	6332	18	e	e	NN
cord-015021-pol2qm74	6332	19	phenotype	phenotype	NN
cord-015021-pol2qm74	6332	20	.	.	.
cord-015021-pol2qm74	6333	1	Spedacally	Spedacally	NNP
cord-015021-pol2qm74	6333	2	,	,	,
cord-015021-pol2qm74	6333	3	CDI4	CDI4	NNP
cord-015021-pol2qm74	6333	4	is	be	VBZ
cord-015021-pol2qm74	6333	5	down	down	RB
cord-015021-pol2qm74	6333	6	-	-	HYPH
cord-015021-pol2qm74	6333	7	regu	regu	NN
cord-015021-pol2qm74	6333	8	/	/	SYM
cord-015021-pol2qm74	6333	9	ated	ate	VBN
cord-015021-pol2qm74	6333	10	,	,	,
cord-015021-pol2qm74	6333	11	along	along	IN
cord-015021-pol2qm74	6333	12	wl~	wl~	NN
cord-015021-pol2qm74	6333	13	CD	CD	NNP
cord-015021-pol2qm74	6333	14	32	32	CD
cord-015021-pol2qm74	6333	15	and	and	CC
cord-015021-pol2qm74	6333	16	CD64	CD64	NNP
cord-015021-pol2qm74	6333	17	.	.	.
cord-015021-pol2qm74	6334	1	Thus	thus	RB
cord-015021-pol2qm74	6334	2	responsiveness	responsiveness	NN
cord-015021-pol2qm74	6334	3	to	to	IN
cord-015021-pol2qm74	6334	4	lipopolysacchmdde	lipopolysacchmdde	NNP
cord-015021-pol2qm74	6334	5	(	(	-LRB-
cord-015021-pol2qm74	6334	6	128	128	CD
cord-015021-pol2qm74	6334	7	)	)	-RRB-
cord-015021-pol2qm74	6334	8	a	a	DT
cord-015021-pol2qm74	6335	1	~xd	~xd	NNP
cord-015021-pol2qm74	6335	2	i	i	PRP
cord-015021-pol2qm74	6335	3	=	=	SYM
cord-015021-pol2qm74	6335	4	m	m	NNP
cord-015021-pol2qm74	6335	5	~	~	NFP
cord-015021-pol2qm74	6335	6	unoglobulin	unoglobulin	NNP
cord-015021-pol2qm74	6335	7	Fe	Fe	NNP
cord-015021-pol2qm74	6335	8	st	st	NNP
cord-015021-pol2qm74	6335	9	~	~	NNP
cord-015021-pol2qm74	6335	10	mu	mu	NNP
cord-015021-pol2qm74	6335	11	/	/	SYM
cord-015021-pol2qm74	6335	12	mtlon	mtlon	NNP
cord-015021-pol2qm74	6335	13	is	be	VBZ
cord-015021-pol2qm74	6335	14	reduced	reduce	VBN
cord-015021-pol2qm74	6335	15	.	.	.
cord-015021-pol2qm74	6336	1	In	in	IN
cord-015021-pol2qm74	6336	2	cert,+rest	cert,+r	JJS
cord-015021-pol2qm74	6336	3	,	,	,
cord-015021-pol2qm74	6336	4	the	the	DT
cord-015021-pol2qm74	6336	5	complement	complement	NN
cord-015021-pol2qm74	6336	6	rote.p	rote.p	TO
cord-015021-pol2qm74	6336	7	tot	tot	NNP
cord-015021-pol2qm74	6336	8	CDC42	CDC42	NNP
cord-015021-pol2qm74	6336	9	is	be	VBZ
cord-015021-pol2qm74	6336	10	u~-regulamd	u~-regulamd	JJR
cord-015021-pol2qm74	6336	11	,	,	,
cord-015021-pol2qm74	6336	12	indicaling	indicale	VBG
cord-015021-pol2qm74	6336	13	Mcremsed	Mcremsed	NNP
cord-015021-pol2qm74	6336	14	re	re	NNP
cord-015021-pol2qm74	6336	15	~	~	CD
cord-015021-pol2qm74	6336	16	ponalx=~ness	ponalx=~ness	NNP
cord-015021-pol2qm74	6336	17	to	to	IN
cord-015021-pol2qm74	6336	18	opsonized	opsonized	NNP
cord-015021-pol2qm74	6336	19	pat	pat	NNP
cord-015021-pol2qm74	6336	20	,	,	,
cord-015021-pol2qm74	6336	21	rotes	rotes	NNP
cord-015021-pol2qm74	6336	22	,	,	,
cord-015021-pol2qm74	6336	23	we	-PRON-	PRP
cord-015021-pol2qm74	6336	24	examined	examine	VBD
cord-015021-pol2qm74	6336	25	monocyte	monocyte	NNP
cord-015021-pol2qm74	6336	26	superna~	superna~	NNS
cord-015021-pol2qm74	6337	1	n	n	NNP
cord-015021-pol2qm74	6337	2	~	~	NNP
cord-015021-pol2qm74	6337	3	s	s	NNP
cord-015021-pol2qm74	6337	4	for	for	IN
cord-015021-pol2qm74	6337	5	production	production	NN
cord-015021-pol2qm74	6337	6	of	of	IN
cord-015021-pol2qm74	6337	7	hzmor	hzmor	NNP
cord-015021-pol2qm74	6337	8	necrosis	necrosis	NN
cord-015021-pol2qm74	6337	9	factor	factor	NN
cord-015021-pol2qm74	6337	10	alpha	alpha	NNP
cord-015021-pol2qm74	6337	11	(	(	-LRB-
cord-015021-pol2qm74	6337	12	TNFg	TNFg	NNP
cord-015021-pol2qm74	6337	13	)	)	-RRB-
cord-015021-pol2qm74	6338	1	following	follow	VBG
cord-015021-pol2qm74	6338	2	IC	IC	NNP
cord-015021-pol2qm74	6338	3	stimulation	stimulation	NN
cord-015021-pol2qm74	6338	4	and	and	CC
cord-015021-pol2qm74	6338	5	showed	show	VBD
cord-015021-pol2qm74	6338	6	that	that	IN
cord-015021-pol2qm74	6338	7	IC	IC	NNP
cord-015021-pol2qm74	6338	8	are	be	VBP
cord-015021-pol2qm74	6338	9	capable	capable	JJ
cord-015021-pol2qm74	6338	10	of	of	IN
cord-015021-pol2qm74	6338	11	provoking	provoke	VBG
cord-015021-pol2qm74	6338	12	~elaase	~elaase	CD
cord-015021-pol2qm74	6338	13	of	of	IN
cord-015021-pol2qm74	6338	14	hrmaunl)reac	hrmaunl)reac	NNP
cord-015021-pol2qm74	6339	1	~ve	~ve	NNP
cord-015021-pol2qm74	6339	2	TNI~.	TNI~.	NNP
cord-015021-pol2qm74	6339	3	J[C	j[c	NN
cord-015021-pol2qm74	6339	4	also	also	RB
cord-015021-pol2qm74	6339	5	increase	increase	VBP
cord-015021-pol2qm74	6339	6	mono	mono	NN
cord-015021-pol2qm74	6339	7	=	=	SYM
cord-015021-pol2qm74	6339	8	yte	yte	NNP
cord-015021-pol2qm74	6339	9	producHon	producHon	NNP
cord-015021-pol2qm74	6339	10	of	of	IN
cord-015021-pol2qm74	6339	11	prnstaglandin	prnstaglandin	NNP
cord-015021-pol2qm74	6339	12	E2	E2	NNP
cord-015021-pol2qm74	6339	13	.	.	.
cord-015021-pol2qm74	6340	1	in	in	IN
cord-015021-pol2qm74	6340	2	summary	summary	NN
cord-015021-pol2qm74	6340	3	,	,	,
cord-015021-pol2qm74	6340	4	~/~ese	~/~ese	NN
cord-015021-pol2qm74	6340	5	results	result	NNS
cord-015021-pol2qm74	6340	6	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	6340	7	Lhmt	Lhmt	NNP
cord-015021-pol2qm74	6340	8	IC	IC	NNP
cord-015021-pol2qm74	6340	9	are	be	VBP
cord-015021-pol2qm74	6340	10	capable	capable	JJ
cord-015021-pol2qm74	6340	11	of	of	IN
cord-015021-pol2qm74	6340	12	indudng	indudng	NN
cord-015021-pol2qm74	6340	13	production	production	NN
cord-015021-pol2qm74	6340	14	of	of	IN
cord-015021-pol2qm74	6340	15	¢ytokines	¢ytokines	NNP
cord-015021-pol2qm74	6340	16	and	and	CC
cord-015021-pol2qm74	6340	17	the	the	DT
cord-015021-pol2qm74	6340	18	imrau	imrau	NNP
cord-015021-pol2qm74	6340	19	-	-	HYPH
cord-015021-pol2qm74	6340	20	nosuppressive	nosuppressive	NNP
cord-015021-pol2qm74	6340	21	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	6340	22	PGE2	PGE2	NNP
cord-015021-pol2qm74	6340	23	.	.	.
cord-015021-pol2qm74	6341	1	IC	IC	NNP
cord-015021-pol2qm74	6341	2	also	also	RB
cord-015021-pol2qm74	6341	3	allez	allez	NNP
cord-015021-pol2qm74	6341	4	~he	~he	NNP
cord-015021-pol2qm74	6341	5	surface	surface	VBP
cord-015021-pol2qm74	6341	6	expression	expression	NN
cord-015021-pol2qm74	6341	7	of	of	IN
cord-015021-pol2qm74	6341	8	important	important	JJ
cord-015021-pol2qm74	6341	9	receptors	receptor	NNS
cord-015021-pol2qm74	6341	10	involved	involve	VBN
cord-015021-pol2qm74	6341	11	in	in	IN
cord-015021-pol2qm74	6341	12	actlvaffon	actlvaffon	NN
cord-015021-pol2qm74	6341	13	by	by	IN
cord-015021-pol2qm74	6341	14	LP~	LP~	NNP
cord-015021-pol2qm74	6341	15	and	and	CC
cord-015021-pol2qm74	6341	16	phagocyIosis	phagocyiosis	NN
cord-015021-pol2qm74	6341	17	.	.	.
cord-015021-pol2qm74	6342	1	Thus	thus	RB
cord-015021-pol2qm74	6342	2	,	,	,
cord-015021-pol2qm74	6342	3	IC	IC	NNP
cord-015021-pol2qm74	6342	4	aze	aze	NNP
cord-015021-pol2qm74	6342	5	competent	competent	JJ
cord-015021-pol2qm74	6342	6	for	for	IN
cord-015021-pol2qm74	6342	7	indud	indud	NNP
cord-015021-pol2qm74	6342	8	/	/	,
cord-015021-pol2qm74	6342	9	on	on	IN
cord-015021-pol2qm74	6342	10	of	of	IN
cord-015021-pol2qm74	6342	11	the	the	DT
cord-015021-pol2qm74	6342	12	mepl	mepl	NNP
cord-015021-pol2qm74	6342	13	/	/	SYM
cord-015021-pol2qm74	6342	14	e	e	NNP
cord-015021-pol2qm74	6342	15	s!0otLse	s!0otLse	NNP
cord-015021-pol2qm74	6342	16	.	.	.
cord-015021-pol2qm74	6343	1	By	by	IN
cord-015021-pol2qm74	6343	2	examining	examine	VBG
cord-015021-pol2qm74	6343	3	m0n0cyte	m0n0cyte	CD
cord-015021-pol2qm74	6343	4	phenotypms	phenotypms	NNP
cord-015021-pol2qm74	6343	5	,	,	,
cord-015021-pol2qm74	6343	6	it	-PRON-	PRP
cord-015021-pol2qm74	6343	7	may	may	MD
cord-015021-pol2qm74	6343	8	be	be	VB
cord-015021-pol2qm74	6343	9	possible	possible	JJ
cord-015021-pol2qm74	6343	10	tO	to	IN
cord-015021-pol2qm74	6343	11	d	d	XX
cord-015021-pol2qm74	6344	1	~mrmkne	~mrmkne	NNP
cord-015021-pol2qm74	6344	2	extent	extent	NN
cord-015021-pol2qm74	6344	3	oHn'u~	oHn'u~	NNP
cord-015021-pol2qm74	6345	1	u	u	NNP
cord-015021-pol2qm74	6345	2	~	~	NNP
cord-015021-pol2qm74	6345	3	e	e	LS
cord-015021-pol2qm74	6345	4	complex	complex	JJ
cord-015021-pol2qm74	6345	5	activation	activation	NN
cord-015021-pol2qm74	6345	6	and	and	CC
cord-015021-pol2qm74	6345	7	predict	predict	VB
cord-015021-pol2qm74	6345	8	immune	immune	JJ
cord-015021-pol2qm74	6345	9	depression	depression	NN
cord-015021-pol2qm74	6345	10	iu	iu	IN
cord-015021-pol2qm74	6345	11	criffcally	criffcally	RB
cord-015021-pol2qm74	6345	12	ill	ill	NNP
cord-015021-pol2qm74	6345	13	pa	pa	NNP
cord-015021-pol2qm74	6345	14	~	~	CD
cord-015021-pol2qm74	6345	15	ents	ent	NNS
cord-015021-pol2qm74	6345	16	.	.	.
cord-015021-pol2qm74	6346	1	A	a	DT
cord-015021-pol2qm74	6346	2	great	great	JJ
cord-015021-pol2qm74	6346	3	deal	deal	NN
cord-015021-pol2qm74	6346	4	of	of	IN
cord-015021-pol2qm74	6346	5	experimental	experimental	JJ
cord-015021-pol2qm74	6346	6	work	work	NN
cord-015021-pol2qm74	6346	7	has	have	VBZ
cord-015021-pol2qm74	6346	8	focused	focus	VBN
cord-015021-pol2qm74	6346	9	on	on	IN
cord-015021-pol2qm74	6346	10	preventing	prevent	VBG
cord-015021-pol2qm74	6346	11	and/or	and/or	CC
cord-015021-pol2qm74	6346	12	treating	treat	VBG
cord-015021-pol2qm74	6346	13	sepsis	sepsis	NN
cord-015021-pol2qm74	6346	14	and	and	CC
cord-015021-pol2qm74	6346	15	organ	organ	NN
cord-015021-pol2qm74	6346	16	failure	failure	NN
cord-015021-pol2qm74	6346	17	following	follow	VBG
cord-015021-pol2qm74	6346	18	injury	injury	NN
cord-015021-pol2qm74	6346	19	.	.	.
cord-015021-pol2qm74	6347	1	Many	many	JJ
cord-015021-pol2qm74	6347	2	of	of	IN
cord-015021-pol2qm74	6347	3	these	these	DT
cord-015021-pol2qm74	6347	4	strategies	strategy	NNS
cord-015021-pol2qm74	6347	5	have	have	VBP
cord-015021-pol2qm74	6347	6	tried	try	VBN
cord-015021-pol2qm74	6347	7	to	to	TO
cord-015021-pol2qm74	6347	8	attack	attack	VB
cord-015021-pol2qm74	6347	9	mediator	mediator	NN
cord-015021-pol2qm74	6347	10	substances	substance	NNS
cord-015021-pol2qm74	6347	11	released	release	VBN
cord-015021-pol2qm74	6347	12	during	during	IN
cord-015021-pol2qm74	6347	13	the	the	DT
cord-015021-pol2qm74	6347	14	systemic	systemic	JJ
cord-015021-pol2qm74	6347	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6347	16	response	response	NN
cord-015021-pol2qm74	6347	17	following	follow	VBG
cord-015021-pol2qm74	6347	18	injury	injury	NN
cord-015021-pol2qm74	6347	19	.	.	.
cord-015021-pol2qm74	6348	1	Sugermann	Sugermann	NNP
cord-015021-pol2qm74	6348	2	has	have	VBZ
cord-015021-pol2qm74	6348	3	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	6348	4	the	the	DT
cord-015021-pol2qm74	6348	5	improvement	improvement	NN
cord-015021-pol2qm74	6348	6	of	of	IN
cord-015021-pol2qm74	6348	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	6348	8	function	function	NN
cord-015021-pol2qm74	6348	9	,	,	,
cord-015021-pol2qm74	6348	10	but	but	CC
cord-015021-pol2qm74	6348	11	not	not	RB
cord-015021-pol2qm74	6348	12	eappillary	eappillary	NNP
cord-015021-pol2qm74	6348	13	leak	leak	NN
cord-015021-pol2qm74	6348	14	using	use	VBG
cord-015021-pol2qm74	6348	15	[	[	-LRB-
cord-015021-pol2qm74	6348	16	buprofen	buprofen	NN
cord-015021-pol2qm74	6348	17	in	in	IN
cord-015021-pol2qm74	6348	18	the	the	DT
cord-015021-pol2qm74	6348	19	porcine	porcine	JJ
cord-015021-pol2qm74	6348	20	model	model	NN
cord-015021-pol2qm74	6348	21	.	.	.
cord-015021-pol2qm74	6349	1	In	in	IN
cord-015021-pol2qm74	6349	2	a	a	DT
cord-015021-pol2qm74	6349	3	clinical	clinical	JJ
cord-015021-pol2qm74	6349	4	trial	trial	NN
cord-015021-pol2qm74	6349	5	,	,	,
cord-015021-pol2qm74	6349	6	Faist	Faist	NNP
cord-015021-pol2qm74	6349	7	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	6349	8	the	the	DT
cord-015021-pol2qm74	6349	9	effectiveness	effectiveness	NN
cord-015021-pol2qm74	6349	10	of	of	IN
cord-015021-pol2qm74	6349	11	Indomethacine	Indomethacine	NNP
cord-015021-pol2qm74	6349	12	in	in	IN
cord-015021-pol2qm74	6349	13	amelierating	amelierate	VBG
cord-015021-pol2qm74	6349	14	the	the	DT
cord-015021-pol2qm74	6349	15	post	post	NN
cord-015021-pol2qm74	6349	16	trauma	trauma	NN
cord-015021-pol2qm74	6349	17	of	of	IN
cord-015021-pol2qm74	6349	18	cellular	cellular	JJ
cord-015021-pol2qm74	6349	19	amenity	amenity	NN
cord-015021-pol2qm74	6349	20	using	use	VBG
cord-015021-pol2qm74	6349	21	in	in	IN
cord-015021-pol2qm74	6349	22	vitro	vitro	FW
cord-015021-pol2qm74	6349	23	parameters	parameter	NNS
cord-015021-pol2qm74	6349	24	.	.	.
cord-015021-pol2qm74	6350	1	Morbidity	morbidity	NN
cord-015021-pol2qm74	6350	2	and	and	CC
cord-015021-pol2qm74	6350	3	mortality	mortality	NN
cord-015021-pol2qm74	6350	4	,	,	,
cord-015021-pol2qm74	6350	5	however	however	RB
cord-015021-pol2qm74	6350	6	,	,	,
cord-015021-pol2qm74	6350	7	were	be	VBD
cord-015021-pol2qm74	6350	8	not	not	RB
cord-015021-pol2qm74	6350	9	different	different	JJ
cord-015021-pol2qm74	6350	10	between	between	IN
cord-015021-pol2qm74	6350	11	control	control	NN
cord-015021-pol2qm74	6350	12	and	and	CC
cord-015021-pol2qm74	6350	13	treatment	treatment	NN
cord-015021-pol2qm74	6350	14	groups	group	NNS
cord-015021-pol2qm74	6350	15	.	.	.
cord-015021-pol2qm74	6351	1	Baue	Baue	NNP
cord-015021-pol2qm74	6351	2	und	und	IN
cord-015021-pol2qm74	6351	3	Chaudry	Chaudry	NNP
cord-015021-pol2qm74	6351	4	have	have	VBP
cord-015021-pol2qm74	6351	5	suggested	suggest	VBN
cord-015021-pol2qm74	6351	6	that	that	IN
cord-015021-pol2qm74	6351	7	ATP	ATP	NNP
cord-015021-pol2qm74	6351	8	magnesium	magnesium	NN
cord-015021-pol2qm74	6351	9	chloride	chloride	NN
cord-015021-pol2qm74	6351	10	may	may	MD
cord-015021-pol2qm74	6351	11	have	have	VB
cord-015021-pol2qm74	6351	12	protective	protective	JJ
cord-015021-pol2qm74	6351	13	effect	effect	NN
cord-015021-pol2qm74	6351	14	in	in	IN
cord-015021-pol2qm74	6351	15	renal	renal	JJ
cord-015021-pol2qm74	6351	16	failure	failure	NN
cord-015021-pol2qm74	6351	17	uM	um	UH
cord-015021-pol2qm74	6351	18	Kupfer	Kupfer	NNP
cord-015021-pol2qm74	6351	19	cell	cell	NN
cord-015021-pol2qm74	6351	20	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6351	21	seen	see	VBN
cord-015021-pol2qm74	6351	22	after	after	IN
cord-015021-pol2qm74	6351	23	shock	shock	NN
cord-015021-pol2qm74	6351	24	.	.	.
cord-015021-pol2qm74	6352	1	Pentoxiphyllin	Pentoxiphyllin	NNP
cord-015021-pol2qm74	6352	2	has	have	VBZ
cord-015021-pol2qm74	6352	3	been	be	VBN
cord-015021-pol2qm74	6352	4	found	find	VBN
cord-015021-pol2qm74	6352	5	to	to	TO
cord-015021-pol2qm74	6352	6	be	be	VB
cord-015021-pol2qm74	6352	7	effective	effective	JJ
cord-015021-pol2qm74	6352	8	in	in	IN
cord-015021-pol2qm74	6352	9	improving	improve	VBG
cord-015021-pol2qm74	6352	10	tissue	tissue	NN
cord-015021-pol2qm74	6352	11	oxygenation	oxygenation	NN
cord-015021-pol2qm74	6352	12	and	and	CC
cord-015021-pol2qm74	6352	13	oxygen	oxygen	NN
cord-015021-pol2qm74	6352	14	consumption	consumption	NN
cord-015021-pol2qm74	6352	15	following	follow	VBG
cord-015021-pol2qm74	6352	16	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6352	17	,	,	,
cord-015021-pol2qm74	6352	18	and	and	CC
cord-015021-pol2qm74	6352	19	there	there	EX
cord-015021-pol2qm74	6352	20	may	may	MD
cord-015021-pol2qm74	6352	21	be	be	VB
cord-015021-pol2qm74	6352	22	promise	promise	NN
cord-015021-pol2qm74	6352	23	for	for	IN
cord-015021-pol2qm74	6352	24	this	this	DT
cord-015021-pol2qm74	6352	25	drug	drug	NN
cord-015021-pol2qm74	6352	26	in	in	IN
cord-015021-pol2qm74	6352	27	the	the	DT
cord-015021-pol2qm74	6352	28	ischemia	ischemia	NN
cord-015021-pol2qm74	6352	29	reperfusion	reperfusion	NN
cord-015021-pol2qm74	6352	30	injury	injury	NN
cord-015021-pol2qm74	6352	31	.	.	.
cord-015021-pol2qm74	6353	1	Monoclonal	monoclonal	JJ
cord-015021-pol2qm74	6353	2	antibodies	antibody	NNS
cord-015021-pol2qm74	6353	3	against	against	IN
cord-015021-pol2qm74	6353	4	endothxin	endothxin	NN
cord-015021-pol2qm74	6353	5	and	and	CC
cord-015021-pol2qm74	6353	6	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6353	7	mediators	mediator	NNS
cord-015021-pol2qm74	6353	8	seemed	seem	VBD
cord-015021-pol2qm74	6353	9	promising	promise	VBG
cord-015021-pol2qm74	6353	10	at	at	IN
cord-015021-pol2qm74	6353	11	first	first	JJ
cord-015021-pol2qm74	6353	12	glance	glance	NN
cord-015021-pol2qm74	6353	13	;	;	:
cord-015021-pol2qm74	6353	14	however	however	RB
cord-015021-pol2qm74	6353	15	,	,	,
cord-015021-pol2qm74	6353	16	preliminiary	preliminiary	DT
cord-015021-pol2qm74	6353	17	clinical	clinical	JJ
cord-015021-pol2qm74	6353	18	data	datum	NNS
cord-015021-pol2qm74	6353	19	of	of	IN
cord-015021-pol2qm74	6353	20	the	the	DT
cord-015021-pol2qm74	6353	21	treatment	treatment	NN
cord-015021-pol2qm74	6353	22	of	of	IN
cord-015021-pol2qm74	6353	23	sepsis	sepsis	NN
cord-015021-pol2qm74	6353	24	with	with	IN
cord-015021-pol2qm74	6353	25	either	either	CC
cord-015021-pol2qm74	6353	26	HA	HA	NNP
cord-015021-pol2qm74	6353	27	-	-	HYPH
cord-015021-pol2qm74	6353	28	IA	IA	NNP
cord-015021-pol2qm74	6353	29	or	or	CC
cord-015021-pol2qm74	6353	30	E5	E5	NNP
cord-015021-pol2qm74	6353	31	monoelonoal	monoelonoal	JJ
cord-015021-pol2qm74	6353	32	antibodies	antibody	NNS
cord-015021-pol2qm74	6353	33	against	against	IN
cord-015021-pol2qm74	6353	34	bacterial	bacterial	JJ
cord-015021-pol2qm74	6353	35	cell	cell	NN
cord-015021-pol2qm74	6353	36	wall	wall	NN
cord-015021-pol2qm74	6353	37	have	have	VBP
cord-015021-pol2qm74	6353	38	been	be	VBN
cord-015021-pol2qm74	6353	39	disappointing	disappointing	JJ
cord-015021-pol2qm74	6353	40	.	.	.
cord-015021-pol2qm74	6354	1	Initial	initial	JJ
cord-015021-pol2qm74	6354	2	studies	study	NNS
cord-015021-pol2qm74	6354	3	with	with	IN
cord-015021-pol2qm74	6354	4	IL	IL	NNP
cord-015021-pol2qm74	6354	5	-	-	:
cord-015021-pol2qm74	6354	6	I	I	NNP
cord-015021-pol2qm74	6354	7	receptor	receptor	NN
cord-015021-pol2qm74	6354	8	antagonist	antagonist	NN
cord-015021-pol2qm74	6354	9	also	also	RB
cord-015021-pol2qm74	6354	10	appeared	appear	VBD
cord-015021-pol2qm74	6354	11	encouraging	encouraging	JJ
cord-015021-pol2qm74	6354	12	,	,	,
cord-015021-pol2qm74	6354	13	but	but	CC
cord-015021-pol2qm74	6354	14	no	no	DT
cord-015021-pol2qm74	6354	15	difference	difference	NN
cord-015021-pol2qm74	6354	16	was	be	VBD
cord-015021-pol2qm74	6354	17	seen	see	VBN
cord-015021-pol2qm74	6354	18	in	in	IN
cord-015021-pol2qm74	6354	19	the	the	DT
cord-015021-pol2qm74	6354	20	most	most	RBS
cord-015021-pol2qm74	6354	21	recent	recent	JJ
cord-015021-pol2qm74	6354	22	trial	trial	NN
cord-015021-pol2qm74	6354	23	.	.	.
cord-015021-pol2qm74	6355	1	Currently	currently	RB
cord-015021-pol2qm74	6355	2	studies	study	NNS
cord-015021-pol2qm74	6355	3	are	be	VBP
cord-015021-pol2qm74	6355	4	ongoing	ongoing	JJ
cord-015021-pol2qm74	6355	5	with	with	IN
cord-015021-pol2qm74	6355	6	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	6355	7	antibodies	antibody	NNS
cord-015021-pol2qm74	6355	8	to	to	TO
cord-015021-pol2qm74	6355	9	tumor	tumor	NN
cord-015021-pol2qm74	6355	10	necrosis	necrosis	NN
cord-015021-pol2qm74	6355	11	factor	factor	NN
cord-015021-pol2qm74	6355	12	which	which	WDT
cord-015021-pol2qm74	6355	13	may	may	MD
cord-015021-pol2qm74	6355	14	have	have	VB
cord-015021-pol2qm74	6355	15	more	more	JJR
cord-015021-pol2qm74	6355	16	efficacy	efficacy	NN
cord-015021-pol2qm74	6355	17	given	give	VBN
cord-015021-pol2qm74	6355	18	the	the	DT
cord-015021-pol2qm74	6355	19	fact	fact	NN
cord-015021-pol2qm74	6355	20	that	that	IN
cord-015021-pol2qm74	6355	21	it	-PRON-	PRP
cord-015021-pol2qm74	6355	22	is	be	VBZ
cord-015021-pol2qm74	6355	23	a	a	DT
cord-015021-pol2qm74	6355	24	macrophage	macrophage	NN
cord-015021-pol2qm74	6355	25	mediator	mediator	NN
cord-015021-pol2qm74	6355	26	released	release	VBN
cord-015021-pol2qm74	6355	27	by	by	IN
cord-015021-pol2qm74	6355	28	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6355	29	.	.	.
cord-015021-pol2qm74	6356	1	Although	although	IN
cord-015021-pol2qm74	6356	2	we	-PRON-	PRP
cord-015021-pol2qm74	6356	3	seem	seem	VBP
cord-015021-pol2qm74	6356	4	closer	close	RBR
cord-015021-pol2qm74	6356	5	to	to	IN
cord-015021-pol2qm74	6356	6	understanding	understanding	NN
cord-015021-pol2qm74	6356	7	and	and	CC
cord-015021-pol2qm74	6356	8	preventing	prevent	VBG
cord-015021-pol2qm74	6356	9	the	the	DT
cord-015021-pol2qm74	6356	10	problems	problem	NNS
cord-015021-pol2qm74	6356	11	of	of	IN
cord-015021-pol2qm74	6356	12	sepsis	sepsis	NN
cord-015021-pol2qm74	6356	13	and	and	CC
cord-015021-pol2qm74	6356	14	organg	organg	NNP
cord-015021-pol2qm74	6356	15	failure	failure	NN
cord-015021-pol2qm74	6356	16	after	after	IN
cord-015021-pol2qm74	6356	17	trauma	trauma	NN
cord-015021-pol2qm74	6356	18	,	,	,
cord-015021-pol2qm74	6356	19	we	-PRON-	PRP
cord-015021-pol2qm74	6356	20	must	must	MD
cord-015021-pol2qm74	6356	21	continue	continue	VB
cord-015021-pol2qm74	6356	22	to	to	TO
cord-015021-pol2qm74	6356	23	appreciate	appreciate	VB
cord-015021-pol2qm74	6356	24	the	the	DT
cord-015021-pol2qm74	6356	25	complex	complex	JJ
cord-015021-pol2qm74	6356	26	interrelationships	interrelationship	NNS
cord-015021-pol2qm74	6356	27	and	and	CC
cord-015021-pol2qm74	6356	28	delicate	delicate	JJ
cord-015021-pol2qm74	6356	29	balances	balance	NNS
cord-015021-pol2qm74	6356	30	inherent	inherent	JJ
cord-015021-pol2qm74	6356	31	in	in	IN
cord-015021-pol2qm74	6356	32	the	the	DT
cord-015021-pol2qm74	6356	33	host	host	NN
cord-015021-pol2qm74	6356	34	defense	defense	NN
cord-015021-pol2qm74	6356	35	system	system	NN
cord-015021-pol2qm74	6356	36	.	.	.
cord-015021-pol2qm74	6357	1	Overzealous	overzealous	JJ
cord-015021-pol2qm74	6357	2	attempts	attempt	NNS
cord-015021-pol2qm74	6357	3	at	at	IN
cord-015021-pol2qm74	6357	4	restoring	restore	VBG
cord-015021-pol2qm74	6357	5	immunity	immunity	NN
cord-015021-pol2qm74	6357	6	in	in	IN
cord-015021-pol2qm74	6357	7	the	the	DT
cord-015021-pol2qm74	6357	8	absence	absence	NN
cord-015021-pol2qm74	6357	9	of	of	IN
cord-015021-pol2qm74	6357	10	understanding	understand	VBG
cord-015021-pol2qm74	6357	11	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	6357	12	may	may	MD
cord-015021-pol2qm74	6357	13	be	be	VB
cord-015021-pol2qm74	6357	14	just	just	RB
cord-015021-pol2qm74	6357	15	as	as	RB
cord-015021-pol2qm74	6357	16	dangerous	dangerous	JJ
cord-015021-pol2qm74	6357	17	at	at	IN
cord-015021-pol2qm74	6357	18	post	post	JJ
cord-015021-pol2qm74	6357	19	-	-	JJ
cord-015021-pol2qm74	6357	20	traumatic	traumatic	JJ
cord-015021-pol2qm74	6357	21	immlmospremsion	immlmospremsion	NN
cord-015021-pol2qm74	6357	22	.	.	.
cord-015021-pol2qm74	6358	1	Severe	severe	JJ
cord-015021-pol2qm74	6358	2	acute	acute	JJ
cord-015021-pol2qm74	6358	3	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6358	4	was	be	VBD
cord-015021-pol2qm74	6358	5	caused	cause	VBN
cord-015021-pol2qm74	6358	6	by	by	IN
cord-015021-pol2qm74	6358	7	different	different	JJ
cord-015021-pol2qm74	6358	8	etiologic	etiologic	JJ
cord-015021-pol2qm74	6358	9	factors	factor	NNS
cord-015021-pol2qm74	6358	10	,	,	,
cord-015021-pol2qm74	6358	11	but	but	CC
cord-015021-pol2qm74	6358	12	once	once	IN
cord-015021-pol2qm74	6358	13	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	6358	14	tissues	tissue	NNS
cord-015021-pol2qm74	6358	15	were	be	VBD
cord-015021-pol2qm74	6358	16	infected	infect	VBN
cord-015021-pol2qm74	6358	17	,	,	,
cord-015021-pol2qm74	6358	18	patients	patient	NNS
cord-015021-pol2qm74	6358	19	show	show	VBP
cord-015021-pol2qm74	6358	20	a	a	DT
cord-015021-pol2qm74	6358	21	similar	similar	JJ
cord-015021-pol2qm74	6358	22	pattern	pattern	NN
cord-015021-pol2qm74	6358	23	of	of	IN
cord-015021-pol2qm74	6358	24	aggravation	aggravation	NN
cord-015021-pol2qm74	6358	25	and	and	CC
cord-015021-pol2qm74	6358	26	develop	develop	VB
cord-015021-pol2qm74	6358	27	organ	organ	NN
cord-015021-pol2qm74	6358	28	failure	failure	NN
cord-015021-pol2qm74	6358	29	.	.	.
cord-015021-pol2qm74	6359	1	Remarkable	remarkable	JJ
cord-015021-pol2qm74	6359	2	elevation	elevation	NN
cord-015021-pol2qm74	6359	3	of	of	IN
cord-015021-pol2qm74	6359	4	serum	serum	NN
cord-015021-pol2qm74	6359	5	IL-6	IL-6	NNP
cord-015021-pol2qm74	6359	6	was	be	VBD
cord-015021-pol2qm74	6359	7	unexceptionally	unexceptionally	RB
cord-015021-pol2qm74	6359	8	observed	observe	VBN
cord-015021-pol2qm74	6359	9	in	in	IN
cord-015021-pol2qm74	6359	10	patients	patient	NNS
cord-015021-pol2qm74	6359	11	with	with	IN
cord-015021-pol2qm74	6359	12	severe	severe	JJ
cord-015021-pol2qm74	6359	13	acute	acute	JJ
cord-015021-pol2qm74	6359	14	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6359	15	.	.	.
cord-015021-pol2qm74	6360	1	The	the	DT
cord-015021-pol2qm74	6360	2	serum	serum	NN
cord-015021-pol2qm74	6360	3	levels	level	NNS
cord-015021-pol2qm74	6360	4	were	be	VBD
cord-015021-pol2qm74	6360	5	more	more	JJR
cord-015021-pol2qm74	6360	6	than	than	IN
cord-015021-pol2qm74	6360	7	500	500	CD
cord-015021-pol2qm74	6360	8	pg	pg	NN
cord-015021-pol2qm74	6360	9	/	/	SYM
cord-015021-pol2qm74	6360	10	ml	ml	IN
cord-015021-pol2qm74	6360	11	(	(	-LRB-
cord-015021-pol2qm74	6360	12	normal	normal	JJ
cord-015021-pol2qm74	6360	13	:	:	:
cord-015021-pol2qm74	6360	14	less	less	JJR
cord-015021-pol2qm74	6360	15	than	than	IN
cord-015021-pol2qm74	6360	16	4	4	CD
cord-015021-pol2qm74	6360	17	pg	pg	NN
cord-015021-pol2qm74	6360	18	/	/	SYM
cord-015021-pol2qm74	6360	19	ml	ml	NNP
cord-015021-pol2qm74	6360	20	)	)	-RRB-
cord-015021-pol2qm74	6360	21	during	during	IN
cord-015021-pol2qm74	6360	22	the	the	DT
cord-015021-pol2qm74	6360	23	first	first	JJ
cord-015021-pol2qm74	6360	24	one	one	CD
cord-015021-pol2qm74	6360	25	or	or	CC
cord-015021-pol2qm74	6360	26	two	two	CD
cord-015021-pol2qm74	6360	27	days	day	NNS
cord-015021-pol2qm74	6360	28	after	after	IN
cord-015021-pol2qm74	6360	29	onset	onset	NN
cord-015021-pol2qm74	6360	30	.	.	.
cord-015021-pol2qm74	6361	1	There	there	EX
cord-015021-pol2qm74	6361	2	was	be	VBD
cord-015021-pol2qm74	6361	3	a	a	DT
cord-015021-pol2qm74	6361	4	significant	significant	JJ
cord-015021-pol2qm74	6361	5	correlation	correlation	NN
cord-015021-pol2qm74	6361	6	between	between	IN
cord-015021-pol2qm74	6361	7	the	the	DT
cord-015021-pol2qm74	6361	8	peak	peak	NN
cord-015021-pol2qm74	6361	9	serum	serum	NN
cord-015021-pol2qm74	6361	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	6361	11	level	level	NN
cord-015021-pol2qm74	6361	12	and	and	CC
cord-015021-pol2qm74	6361	13	the	the	DT
cord-015021-pol2qm74	6361	14	number	number	NN
cord-015021-pol2qm74	6361	15	of	of	IN
cord-015021-pol2qm74	6361	16	organs	organ	NNS
cord-015021-pol2qm74	6361	17	showing	show	VBG
cord-015021-pol2qm74	6361	18	failure	failure	NN
cord-015021-pol2qm74	6361	19	(	(	-LRB-
cord-015021-pol2qm74	6361	20	r=0.883	r=0.883	NNS
cord-015021-pol2qm74	6361	21	)	)	-RRB-
cord-015021-pol2qm74	6361	22	.	.	.
cord-015021-pol2qm74	6362	1	TNF	TNF	NNP
cord-015021-pol2qm74	6362	2	-	-	:
cord-015021-pol2qm74	6362	3	a	a	DT
cord-015021-pol2qm74	6362	4	production	production	NN
cord-015021-pol2qm74	6362	5	by	by	IN
cord-015021-pol2qm74	6362	6	isolated	isolate	VBN
cord-015021-pol2qm74	6362	7	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6362	8	macrophages	macrophage	NNS
cord-015021-pol2qm74	6362	9	following	follow	VBG
cord-015021-pol2qm74	6362	10	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	6362	11	(	(	-LRB-
cord-015021-pol2qm74	6362	12	LPS	LPS	NNP
cord-015021-pol2qm74	6362	13	)	)	-RRB-
cord-015021-pol2qm74	6362	14	stimulation	stimulation	NN
cord-015021-pol2qm74	6362	15	was	be	VBD
cord-015021-pol2qm74	6362	16	significantly	significantly	RB
cord-015021-pol2qm74	6362	17	increased	increase	VBN
cord-015021-pol2qm74	6362	18	in	in	IN
cord-015021-pol2qm74	6362	19	cerulein	cerulein	NN
cord-015021-pol2qm74	6362	20	-	-	HYPH
cord-015021-pol2qm74	6362	21	induced	induce	VBN
cord-015021-pol2qm74	6362	22	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6362	23	rats	rat	NNS
cord-015021-pol2qm74	6362	24	.	.	.
cord-015021-pol2qm74	6363	1	Serum	serum	NN
cord-015021-pol2qm74	6363	2	TNF	TNF	NNP
cord-015021-pol2qm74	6363	3	-	-	:
cord-015021-pol2qm74	6363	4	a	a	DT
cord-015021-pol2qm74	6363	5	activity	activity	NN
cord-015021-pol2qm74	6363	6	was	be	VBD
cord-015021-pol2qm74	6363	7	elevated	elevate	VBN
cord-015021-pol2qm74	6363	8	following	follow	VBG
cord-015021-pol2qm74	6363	9	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	6363	10	administration	administration	NN
cord-015021-pol2qm74	6363	11	of	of	IN
cord-015021-pol2qm74	6363	12	LPS	LPS	NNP
cord-015021-pol2qm74	6363	13	as	as	IN
cord-015021-pol2qm74	6363	14	the	the	DT
cord-015021-pol2qm74	6363	15	septic	septic	JJ
cord-015021-pol2qm74	6363	16	challenge	challenge	NN
cord-015021-pol2qm74	6363	17	both	both	CC
cord-015021-pol2qm74	6363	18	in	in	IN
cord-015021-pol2qm74	6363	19	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6363	20	rats	rat	NNS
cord-015021-pol2qm74	6363	21	and	and	CC
cord-015021-pol2qm74	6363	22	in	in	IN
cord-015021-pol2qm74	6363	23	control	control	NN
cord-015021-pol2qm74	6363	24	rats	rat	NNS
cord-015021-pol2qm74	6363	25	,	,	,
cord-015021-pol2qm74	6363	26	being	be	VBG
cord-015021-pol2qm74	6363	27	significantly	significantly	RB
cord-015021-pol2qm74	6363	28	higher	high	JJR
cord-015021-pol2qm74	6363	29	in	in	IN
cord-015021-pol2qm74	6363	30	the	the	DT
cord-015021-pol2qm74	6363	31	former	former	JJ
cord-015021-pol2qm74	6363	32	(	(	-LRB-
cord-015021-pol2qm74	6363	33	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6363	34	)	)	-RRB-
cord-015021-pol2qm74	6363	35	.	.	.
cord-015021-pol2qm74	6364	1	Histological	histological	JJ
cord-015021-pol2qm74	6364	2	findings	finding	NNS
cord-015021-pol2qm74	6364	3	and	and	CC
cord-015021-pol2qm74	6364	4	liver	liver	NN
cord-015021-pol2qm74	6364	5	function	function	NN
cord-015021-pol2qm74	6364	6	tests	test	NNS
cord-015021-pol2qm74	6364	7	revealed	reveal	VBD
cord-015021-pol2qm74	6364	8	that	that	IN
cord-015021-pol2qm74	6364	9	LPS	LPS	NNP
cord-015021-pol2qm74	6364	10	induced	induce	VBD
cord-015021-pol2qm74	6364	11	more	more	RBR
cord-015021-pol2qm74	6364	12	severe	severe	JJ
cord-015021-pol2qm74	6364	13	liver	liver	NN
cord-015021-pol2qm74	6364	14	damage	damage	NN
cord-015021-pol2qm74	6364	15	in	in	IN
cord-015021-pol2qm74	6364	16	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6364	17	rats	rat	NNS
cord-015021-pol2qm74	6364	18	than	than	IN
cord-015021-pol2qm74	6364	19	in	in	IN
cord-015021-pol2qm74	6364	20	control	control	NN
cord-015021-pol2qm74	6364	21	rats	rat	NNS
cord-015021-pol2qm74	6364	22	.	.	.
cord-015021-pol2qm74	6365	1	These	these	DT
cord-015021-pol2qm74	6365	2	results	result	NNS
cord-015021-pol2qm74	6365	3	indicate	indicate	VBP
cord-015021-pol2qm74	6365	4	that	that	IN
cord-015021-pol2qm74	6365	5	increased	increase	VBN
cord-015021-pol2qm74	6365	6	TNF	TNF	NNP
cord-015021-pol2qm74	6365	7	-	-	:
cord-015021-pol2qm74	6365	8	a	a	DT
cord-015021-pol2qm74	6365	9	production	production	NN
cord-015021-pol2qm74	6365	10	by	by	IN
cord-015021-pol2qm74	6365	11	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6365	12	macrophages	macrophage	NNS
cord-015021-pol2qm74	6365	13	in	in	IN
cord-015021-pol2qm74	6365	14	acute	acute	JJ
cord-015021-pol2qm74	6365	15	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6365	16	augmented	augment	VBD
cord-015021-pol2qm74	6365	17	LPS	LPS	NNP
cord-015021-pol2qm74	6365	18	-	-	HYPH
cord-015021-pol2qm74	6365	19	induced	induce	VBN
cord-015021-pol2qm74	6365	20	liver	liver	NN
cord-015021-pol2qm74	6365	21	injury	injury	NN
cord-015021-pol2qm74	6365	22	.	.	.
cord-015021-pol2qm74	6366	1	Organ	organ	NN
cord-015021-pol2qm74	6366	2	failure	failure	NN
cord-015021-pol2qm74	6366	3	in	in	IN
cord-015021-pol2qm74	6366	4	severe	severe	JJ
cord-015021-pol2qm74	6366	5	acute	acute	JJ
cord-015021-pol2qm74	6366	6	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6366	7	could	could	MD
cord-015021-pol2qm74	6366	8	be	be	VB
cord-015021-pol2qm74	6366	9	caused	cause	VBN
cord-015021-pol2qm74	6366	10	,	,	,
cord-015021-pol2qm74	6366	11	at	at	IN
cord-015021-pol2qm74	6366	12	least	least	JJS
cord-015021-pol2qm74	6366	13	in	in	IN
cord-015021-pol2qm74	6366	14	part	part	NN
cord-015021-pol2qm74	6366	15	,	,	,
cord-015021-pol2qm74	6366	16	by	by	IN
cord-015021-pol2qm74	6366	17	increased	increase	VBN
cord-015021-pol2qm74	6366	18	cytokine	cytokine	NN
cord-015021-pol2qm74	6366	19	production	production	NN
cord-015021-pol2qm74	6366	20	.	.	.
cord-015021-pol2qm74	6367	1	It	-PRON-	PRP
cord-015021-pol2qm74	6367	2	is	be	VBZ
cord-015021-pol2qm74	6367	3	clear	clear	JJ
cord-015021-pol2qm74	6367	4	now	now	RB
cord-015021-pol2qm74	6367	5	,	,	,
cord-015021-pol2qm74	6367	6	that	that	IN
cord-015021-pol2qm74	6367	7	in	in	IN
cord-015021-pol2qm74	6367	8	MODS	MODS	NNP
cord-015021-pol2qm74	6367	9	,	,	,
cord-015021-pol2qm74	6367	10	organ	organ	NN
cord-015021-pol2qm74	6367	11	injury	injury	NN
cord-015021-pol2qm74	6367	12	is	be	VBZ
cord-015021-pol2qm74	6367	13	not	not	RB
cord-015021-pol2qm74	6367	14	directly	directly	RB
cord-015021-pol2qm74	6367	15	due	due	JJ
cord-015021-pol2qm74	6367	16	to	to	IN
cord-015021-pol2qm74	6367	17	exogenous	exogenous	JJ
cord-015021-pol2qm74	6367	18	factors	factor	NNS
cord-015021-pol2qm74	6367	19	,	,	,
cord-015021-pol2qm74	6367	20	such	such	JJ
cord-015021-pol2qm74	6367	21	as	as	IN
cord-015021-pol2qm74	6367	22	bacteria	bacteria	NNS
cord-015021-pol2qm74	6367	23	or	or	CC
cord-015021-pol2qm74	6367	24	toxins	toxin	NNS
cord-015021-pol2qm74	6367	25	,	,	,
cord-015021-pol2qm74	6367	26	but	but	CC
cord-015021-pol2qm74	6367	27	instead	instead	RB
cord-015021-pol2qm74	6367	28	is	be	VBZ
cord-015021-pol2qm74	6367	29	largely	largely	RB
cord-015021-pol2qm74	6367	30	a	a	DT
cord-015021-pol2qm74	6367	31	consequence	consequence	NN
cord-015021-pol2qm74	6367	32	of	of	IN
cord-015021-pol2qm74	6367	33	the	the	DT
cord-015021-pol2qm74	6367	34	host	host	NN
cord-015021-pol2qm74	6367	35	's	's	POS
cord-015021-pol2qm74	6367	36	own	own	JJ
cord-015021-pol2qm74	6367	37	endogenously	endogenously	RB
cord-015021-pol2qm74	6367	38	produced	produce	VBN
cord-015021-pol2qm74	6367	39	mediators	mediator	NNS
cord-015021-pol2qm74	6367	40	.	.	.
cord-015021-pol2qm74	6368	1	There	there	EX
cord-015021-pol2qm74	6368	2	is	be	VBZ
cord-015021-pol2qm74	6368	3	an	an	DT
cord-015021-pol2qm74	6368	4	extensive	extensive	JJ
cord-015021-pol2qm74	6368	5	body	body	NN
cord-015021-pol2qm74	6368	6	of	of	IN
cord-015021-pol2qm74	6368	7	literature	literature	NN
cord-015021-pol2qm74	6368	8	on	on	IN
cord-015021-pol2qm74	6368	9	the	the	DT
cord-015021-pol2qm74	6368	10	inhibition	inhibition	NN
cord-015021-pol2qm74	6368	11	of	of	IN
cord-015021-pol2qm74	6368	12	mediator	mediator	NN
cord-015021-pol2qm74	6368	13	production	production	NN
cord-015021-pol2qm74	6368	14	,	,	,
cord-015021-pol2qm74	6368	15	release	release	NN
cord-015021-pol2qm74	6368	16	and	and	CC
cord-015021-pol2qm74	6368	17	action	action	NN
cord-015021-pol2qm74	6368	18	in	in	IN
cord-015021-pol2qm74	6368	19	different	different	JJ
cord-015021-pol2qm74	6368	20	cascade	cascade	NN
cord-015021-pol2qm74	6368	21	systems	system	NNS
cord-015021-pol2qm74	6368	22	by	by	IN
cord-015021-pol2qm74	6368	23	glucocorticoids	glucocorticoid	NNS
cord-015021-pol2qm74	6368	24	.	.	.
cord-015021-pol2qm74	6369	1	They	-PRON-	PRP
cord-015021-pol2qm74	6369	2	can	can	MD
cord-015021-pol2qm74	6369	3	serve	serve	VB
cord-015021-pol2qm74	6369	4	as	as	IN
cord-015021-pol2qm74	6369	5	a	a	DT
cord-015021-pol2qm74	6369	6	host	host	NN
cord-015021-pol2qm74	6369	7	protection	protection	NN
cord-015021-pol2qm74	6369	8	against	against	IN
cord-015021-pol2qm74	6369	9	overactive	overactive	JJ
cord-015021-pol2qm74	6369	10	defense	defense	NN
cord-015021-pol2qm74	6369	11	reactions	reaction	NNS
cord-015021-pol2qm74	6369	12	if	if	IN
cord-015021-pol2qm74	6369	13	used	use	VBN
cord-015021-pol2qm74	6369	14	adequately	adequately	RB
cord-015021-pol2qm74	6369	15	.	.	.
cord-015021-pol2qm74	6370	1	A	a	DT
cord-015021-pol2qm74	6370	2	new	new	JJ
cord-015021-pol2qm74	6370	3	understanding	understanding	NN
cord-015021-pol2qm74	6370	4	of	of	IN
cord-015021-pol2qm74	6370	5	the	the	DT
cord-015021-pol2qm74	6370	6	regulation	regulation	NN
cord-015021-pol2qm74	6370	7	of	of	IN
cord-015021-pol2qm74	6370	8	cytokine	cytokine	NN
cord-015021-pol2qm74	6370	9	synthesis	synthesis	NN
cord-015021-pol2qm74	6370	10	,	,	,
cord-015021-pol2qm74	6370	11	especially	especially	RB
cord-015021-pol2qm74	6370	12	TNF	TNF	NNP
cord-015021-pol2qm74	6370	13	,	,	,
cord-015021-pol2qm74	6370	14	may	may	MD
cord-015021-pol2qm74	6370	15	lead	lead	VB
cord-015021-pol2qm74	6370	16	to	to	IN
cord-015021-pol2qm74	6370	17	an	an	DT
cord-015021-pol2qm74	6370	18	insight	insight	NN
cord-015021-pol2qm74	6370	19	of	of	IN
cord-015021-pol2qm74	6370	20	the	the	DT
cord-015021-pol2qm74	6370	21	conflicting	conflict	VBG
cord-015021-pol2qm74	6370	22	findings	finding	NNS
cord-015021-pol2qm74	6370	23	between	between	IN
cord-015021-pol2qm74	6370	24	the	the	DT
cord-015021-pol2qm74	6370	25	benefits	benefit	NNS
cord-015021-pol2qm74	6370	26	of	of	IN
cord-015021-pol2qm74	6370	27	glucocorticoid	glucocorticoid	NN
cord-015021-pol2qm74	6370	28	therapy	therapy	NN
cord-015021-pol2qm74	6370	29	in	in	IN
cord-015021-pol2qm74	6370	30	animals	animal	NNS
cord-015021-pol2qm74	6370	31	and	and	CC
cord-015021-pol2qm74	6370	32	its	-PRON-	PRP$
cord-015021-pol2qm74	6370	33	current	current	JJ
cord-015021-pol2qm74	6370	34	failure	failure	NN
cord-015021-pol2qm74	6370	35	in	in	IN
cord-015021-pol2qm74	6370	36	recent	recent	JJ
cord-015021-pol2qm74	6370	37	clinical	clinical	JJ
cord-015021-pol2qm74	6370	38	trials	trial	NNS
cord-015021-pol2qm74	6370	39	.	.	.
cord-015021-pol2qm74	6371	1	Glucocorticoid	Glucocorticoid	NNP
cord-015021-pol2qm74	6371	2	shares	share	VBZ
cord-015021-pol2qm74	6371	3	its	-PRON-	PRP$
cord-015021-pol2qm74	6371	4	role	role	NN
cord-015021-pol2qm74	6371	5	with	with	IN
cord-015021-pol2qm74	6371	6	other	other	JJ
cord-015021-pol2qm74	6371	7	novel	novel	JJ
cord-015021-pol2qm74	6371	8	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6371	9	approaches	approach	NNS
cord-015021-pol2qm74	6372	1	also	also	RB
cord-015021-pol2qm74	6372	2	shown	show	VBN
cord-015021-pol2qm74	6372	3	to	to	TO
cord-015021-pol2qm74	6372	4	be	be	VB
cord-015021-pol2qm74	6372	5	successful	successful	JJ
cord-015021-pol2qm74	6372	6	only	only	RB
cord-015021-pol2qm74	6372	7	in	in	IN
cord-015021-pol2qm74	6372	8	experimental	experimental	JJ
cord-015021-pol2qm74	6372	9	settings	setting	NNS
cord-015021-pol2qm74	6372	10	.	.	.
cord-015021-pol2qm74	6373	1	A	a	DT
cord-015021-pol2qm74	6373	2	mete	mete	NN
cord-015021-pol2qm74	6373	3	-	-	HYPH
cord-015021-pol2qm74	6373	4	analysis	analysis	NN
cord-015021-pol2qm74	6373	5	of	of	IN
cord-015021-pol2qm74	6373	6	steroids	steroid	NNS
cord-015021-pol2qm74	6373	7	in	in	IN
cord-015021-pol2qm74	6373	8	sepsis	sepsis	NN
cord-015021-pol2qm74	6373	9	,	,	,
cord-015021-pol2qm74	6373	10	however	however	RB
cord-015021-pol2qm74	6373	11	,	,	,
cord-015021-pol2qm74	6373	12	revealed	reveal	VBD
cord-015021-pol2qm74	6373	13	a	a	DT
cord-015021-pol2qm74	6373	14	beneficial	beneficial	JJ
cord-015021-pol2qm74	6373	15	effect	effect	NN
cord-015021-pol2qm74	6373	16	in	in	IN
cord-015021-pol2qm74	6373	17	the	the	DT
cord-015021-pol2qm74	6373	18	subgroup	subgroup	NN
cord-015021-pol2qm74	6373	19	of	of	IN
cord-015021-pol2qm74	6373	20	patients	patient	NNS
cord-015021-pol2qm74	6373	21	with	with	IN
cord-015021-pol2qm74	6373	22	gram	gram	JJ
cord-015021-pol2qm74	6373	23	-	-	HYPH
cord-015021-pol2qm74	6373	24	negative	negative	JJ
cord-015021-pol2qm74	6373	25	infections	infection	NNS
cord-015021-pol2qm74	6373	26	.	.	.
cord-015021-pol2qm74	6374	1	There	there	EX
cord-015021-pol2qm74	6374	2	is	be	VBZ
cord-015021-pol2qm74	6374	3	now	now	RB
cord-015021-pol2qm74	6374	4	a	a	DT
cord-015021-pol2qm74	6374	5	series	series	NN
cord-015021-pol2qm74	6374	6	of	of	IN
cord-015021-pol2qm74	6374	7	arguments	argument	NNS
cord-015021-pol2qm74	6374	8	to	to	TO
cord-015021-pol2qm74	6374	9	reevaluate	reevaluate	VB
cord-015021-pol2qm74	6374	10	the	the	DT
cord-015021-pol2qm74	6374	11	indication	indication	NN
cord-015021-pol2qm74	6374	12	for	for	IN
cord-015021-pol2qm74	6374	13	steroid	steroid	NN
cord-015021-pol2qm74	6374	14	thera	thera	NN
cord-015021-pol2qm74	6374	15	-	-	HYPH
cord-015021-pol2qm74	6374	16	py	py	NN
cord-015021-pol2qm74	6374	17	and/or	and/or	CC
cord-015021-pol2qm74	6374	18	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	6374	19	in	in	IN
cord-015021-pol2qm74	6374	20	MODS	mods	NN
cord-015021-pol2qm74	6374	21	and	and	CC
cord-015021-pol2qm74	6374	22	sepsis	sepsis	NN
cord-015021-pol2qm74	6374	23	.	.	.
cord-015021-pol2qm74	6375	1	Honjo	Honjo	NNP
cord-015021-pol2qm74	6375	2	i-1	i-1	NNP
cord-015021-pol2qm74	6375	3	-	-	HYPH
cord-015021-pol2qm74	6375	4	1	1	CD
cord-015021-pol2qm74	6375	5	,	,	,
cord-015021-pol2qm74	6375	6	Kumamoto	Kumamoto	NNP
cord-015021-pol2qm74	6375	7	860	860	CD
cord-015021-pol2qm74	6376	1	,	,	,
cord-015021-pol2qm74	6376	2	Japan	Japan	NNP
cord-015021-pol2qm74	6376	3	IN	in	IN
cord-015021-pol2qm74	6376	4	SEPTIC	septic	JJ
cord-015021-pol2qm74	6376	5	SHOCK	shock	NN
cord-015021-pol2qm74	6376	6	J.	J.	NNP
cord-015021-pol2qm74	6376	7	Briegel	Briegel	NNP
cord-015021-pol2qm74	6376	8	,	,	,
cord-015021-pol2qm74	6376	9	M.	M.	NNP
cord-015021-pol2qm74	6376	10	Halter	Halter	NNP
cord-015021-pol2qm74	6376	11	,	,	,
cord-015021-pol2qm74	6376	12	H.	H.	NNP
cord-015021-pol2qm74	6376	13	Forst	Forst	NNP
cord-015021-pol2qm74	6376	14	,	,	,
cord-015021-pol2qm74	6376	15	W.	W.	NNP
cord-015021-pol2qm74	6376	16	Kellermaun	Kellermaun	NNP
cord-015021-pol2qm74	6376	17	,	,	,
cord-015021-pol2qm74	6376	18	M.	M.	NNP
cord-015021-pol2qm74	6376	19	Bittl	Bittl	NNP
cord-015021-pol2qm74	6376	20	,	,	,
cord-015021-pol2qm74	6376	21	K.	K.	NNP
cord-015021-pol2qm74	6376	22	Peter	Peter	NNP
cord-015021-pol2qm74	6376	23	Imrodnetlea	Imrodnetlea	NNP
cord-015021-pol2qm74	6376	24	and	and	CC
cord-015021-pol2qm74	6376	25	Methods	method	NNS
cord-015021-pol2qm74	6376	26	:	:	:
cord-015021-pol2qm74	6376	27	Hydrocortisone	Hydrocortisone	NNP
cord-015021-pol2qm74	6376	28	(	(	-LRB-
cord-015021-pol2qm74	6376	29	HC	HC	NNP
cord-015021-pol2qm74	6376	30	)	)	-RRB-
cord-015021-pol2qm74	6376	31	at	at	IN
cord-015021-pol2qm74	6376	32	an	an	DT
cord-015021-pol2qm74	6376	33	infusion	infusion	NN
cord-015021-pol2qm74	6376	34	rate	rate	NN
cord-015021-pol2qm74	6376	35	similar	similar	JJ
cord-015021-pol2qm74	6376	36	to	to	IN
cord-015021-pol2qm74	6376	37	the	the	DT
cord-015021-pol2qm74	6376	38	maximal	maximal	JJ
cord-015021-pol2qm74	6376	39	secretory	secretory	JJ
cord-015021-pol2qm74	6376	40	rate	rate	NN
cord-015021-pol2qm74	6376	41	of	of	IN
cord-015021-pol2qm74	6376	42	cortisol	cortisol	NN
cord-015021-pol2qm74	6376	43	in	in	IN
cord-015021-pol2qm74	6376	44	man	man	NN
cord-015021-pol2qm74	6376	45	improves	improve	VBZ
cord-015021-pol2qm74	6376	46	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	6376	47	in	in	IN
cord-015021-pol2qm74	6376	48	human	human	JJ
cord-015021-pol2qm74	6376	49	septic	septic	JJ
cord-015021-pol2qm74	6376	50	shock	shock	NN
cord-015021-pol2qm74	6376	51	(	(	-LRB-
cord-015021-pol2qm74	6376	52	1	1	CD
cord-015021-pol2qm74	6376	53	)	)	-RRB-
cord-015021-pol2qm74	6376	54	.	.	.
cord-015021-pol2qm74	6377	1	We	-PRON-	PRP
cord-015021-pol2qm74	6377	2	hypothesized	hypothesize	VBD
cord-015021-pol2qm74	6377	3	that	that	IN
cord-015021-pol2qm74	6377	4	the	the	DT
cord-015021-pol2qm74	6377	5	HC	HC	NNP
cord-015021-pol2qm74	6377	6	-	-	HYPH
cord-015021-pol2qm74	6377	7	induced	induce	VBN
cord-015021-pol2qm74	6377	8	hypercortisolemia	hypercortisolemia	NN
cord-015021-pol2qm74	6377	9	prevents	prevent	VBZ
cord-015021-pol2qm74	6377	10	a	a	DT
cord-015021-pol2qm74	6377	11	harmful	harmful	JJ
cord-015021-pol2qm74	6377	12	overshoot	overshoot	NN
cord-015021-pol2qm74	6377	13	of	of	IN
cord-015021-pol2qm74	6377	14	immune	immune	JJ
cord-015021-pol2qm74	6377	15	reactions	reaction	NNS
cord-015021-pol2qm74	6377	16	.	.	.
cord-015021-pol2qm74	6378	1	To	to	TO
cord-015021-pol2qm74	6378	2	test	test	VB
cord-015021-pol2qm74	6378	3	this	this	DT
cord-015021-pol2qm74	6378	4	hypothesis	hypothesis	NN
cord-015021-pol2qm74	6378	5	we	-PRON-	PRP
cord-015021-pol2qm74	6378	6	prospectively	prospectively	RB
cord-015021-pol2qm74	6378	7	investigated	investigate	VBD
cord-015021-pol2qm74	6378	8	12	12	CD
cord-015021-pol2qm74	6378	9	patients	patient	NNS
cord-015021-pol2qm74	6378	10	admitted	admit	VBN
cord-015021-pol2qm74	6378	11	to	to	IN
cord-015021-pol2qm74	6378	12	the	the	DT
cord-015021-pol2qm74	6378	13	ICU	ICU	NNP
cord-015021-pol2qm74	6378	14	in	in	IN
cord-015021-pol2qm74	6378	15	refractory	refractory	JJ
cord-015021-pol2qm74	6378	16	septic	septic	JJ
cord-015021-pol2qm74	6378	17	shock	shock	NN
cord-015021-pol2qm74	6378	18	.	.	.
cord-015021-pol2qm74	6379	1	After	after	IN
cord-015021-pol2qm74	6379	2	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6379	3	(	(	-LRB-
cord-015021-pol2qm74	6379	4	mechanical	mechanical	JJ
cord-015021-pol2qm74	6379	5	ventilation	ventilation	NN
cord-015021-pol2qm74	6379	6	,	,	,
cord-015021-pol2qm74	6379	7	fluid	fluid	JJ
cord-015021-pol2qm74	6379	8	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6379	9	,	,	,
cord-015021-pol2qm74	6379	10	titration	titration	NN
cord-015021-pol2qm74	6379	11	of	of	IN
cord-015021-pol2qm74	6379	12	vasopressors	vasopressor	NNS
cord-015021-pol2qm74	6379	13	,	,	,
cord-015021-pol2qm74	6379	14	and	and	CC
cord-015021-pol2qm74	6379	15	initiation	initiation	NN
cord-015021-pol2qm74	6379	16	of	of	IN
cord-015021-pol2qm74	6379	17	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	6379	18	therapy	therapy	NN
cord-015021-pol2qm74	6379	19	)	)	-RRB-
cord-015021-pol2qm74	6380	1	HC	HC	NNP
cord-015021-pol2qm74	6380	2	Was	be	VBD
cord-015021-pol2qm74	6380	3	started	start	VBN
cord-015021-pol2qm74	6380	4	with	with	IN
cord-015021-pol2qm74	6380	5	a	a	DT
cord-015021-pol2qm74	6380	6	loading	loading	NN
cord-015021-pol2qm74	6380	7	dose	dose	NN
cord-015021-pol2qm74	6380	8	of	of	IN
cord-015021-pol2qm74	6380	9	100	100	CD
cord-015021-pol2qm74	6380	10	mg/	mg/	NN
cord-015021-pol2qm74	6380	11	30	30	CD
cord-015021-pol2qm74	6380	12	rain	rain	NN
cord-015021-pol2qm74	6380	13	,	,	,
cord-015021-pol2qm74	6380	14	followed	follow	VBN
cord-015021-pol2qm74	6380	15	by	by	IN
cord-015021-pol2qm74	6380	16	a	a	DT
cord-015021-pol2qm74	6380	17	continuous	continuous	JJ
cord-015021-pol2qm74	6380	18	infusion	infusion	NN
cord-015021-pol2qm74	6380	19	(	(	-LRB-
cord-015021-pol2qm74	6380	20	10	10	CD
cord-015021-pol2qm74	6380	21	mggh	mggh	NNS
cord-015021-pol2qm74	6380	22	)	)	-RRB-
cord-015021-pol2qm74	6380	23	.	.	.
cord-015021-pol2qm74	6381	1	With	with	IN
cord-015021-pol2qm74	6381	2	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	6381	3	improvement	improvement	NN
cord-015021-pol2qm74	6381	4	(	(	-LRB-
cord-015021-pol2qm74	6381	5	dopamine	dopamine	NN
cord-015021-pol2qm74	6381	6	<	<	XX
cord-015021-pol2qm74	6381	7	2	2	CD
cord-015021-pol2qm74	6381	8	gg	gg	NNP
cord-015021-pol2qm74	6381	9	/	/	SYM
cord-015021-pol2qm74	6381	10	kg	kg	NNP
cord-015021-pol2qm74	6381	11	/	/	SYM
cord-015021-pol2qm74	6381	12	min	min	NN
cord-015021-pol2qm74	6381	13	)	)	-RRB-
cord-015021-pol2qm74	6381	14	the	the	DT
cord-015021-pol2qm74	6381	15	infusion	infusion	NN
cord-015021-pol2qm74	6381	16	rate	rate	NN
cord-015021-pol2qm74	6381	17	nfHC	nfhc	NN
cord-015021-pol2qm74	6381	18	was	be	VBD
cord-015021-pol2qm74	6381	19	tapered	taper	VBN
cord-015021-pol2qm74	6381	20	over	over	IN
cord-015021-pol2qm74	6381	21	a	a	DT
cord-015021-pol2qm74	6381	22	period	period	NN
cord-015021-pol2qm74	6381	23	of	of	IN
cord-015021-pol2qm74	6381	24	3	3	CD
cord-015021-pol2qm74	6381	25	days	day	NNS
cord-015021-pol2qm74	6381	26	.	.	.
cord-015021-pol2qm74	6382	1	Phospbolipase	Phospbolipase	NNP
cord-015021-pol2qm74	6382	2	A	a	DT
cord-015021-pol2qm74	6382	3	2	2	CD
cord-015021-pol2qm74	6382	4	(	(	-LRB-
cord-015021-pol2qm74	6382	5	PLA2	PLA2	NNP
cord-015021-pol2qm74	6382	6	)	)	-RRB-
cord-015021-pol2qm74	6382	7	,	,	,
cord-015021-pol2qm74	6382	8	C	c	NN
cord-015021-pol2qm74	6382	9	-	-	HYPH
cord-015021-pol2qm74	6382	10	reactive	reactive	JJ
cord-015021-pol2qm74	6382	11	protein	protein	NN
cord-015021-pol2qm74	6382	12	(	(	-LRB-
cord-015021-pol2qm74	6382	13	CRP	CRP	NNP
cord-015021-pol2qm74	6382	14	)	)	-RRB-
cord-015021-pol2qm74	6382	15	,	,	,
cord-015021-pol2qm74	6382	16	and	and	CC
cord-015021-pol2qm74	6382	17	elastase	elastase	NN
cord-015021-pol2qm74	6382	18	-	-	HYPH
cord-015021-pol2qm74	6382	19	proteinase	proteinase	NN
cord-015021-pol2qm74	6382	20	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6382	21	complex	complex	NN
cord-015021-pol2qm74	6383	1	(	(	-LRB-
cord-015021-pol2qm74	6383	2	E	e	NN
cord-015021-pol2qm74	6383	3	-	-	NN
cord-015021-pol2qm74	6383	4	PI	pi	NN
cord-015021-pol2qm74	6383	5	)	)	-RRB-
cord-015021-pol2qm74	6383	6	were	be	VBD
cord-015021-pol2qm74	6383	7	deierminated	deierminate	VBN
cord-015021-pol2qm74	6383	8	daily	daily	RB
cord-015021-pol2qm74	6383	9	.	.	.
cord-015021-pol2qm74	6384	1	Results	result	NNS
cord-015021-pol2qm74	6384	2	:	:	:
cord-015021-pol2qm74	6385	1	According	accord	VBG
cord-015021-pol2qm74	6385	2	to	to	IN
cord-015021-pol2qm74	6385	3	our	-PRON-	PRP$
cord-015021-pol2qm74	6385	4	previous	previous	JJ
cord-015021-pol2qm74	6385	5	results	result	NNS
cord-015021-pol2qm74	6385	6	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	6385	7	improved	improve	VBD
cord-015021-pol2qm74	6385	8	during	during	IN
cord-015021-pol2qm74	6385	9	HC	HC	NNP
cord-015021-pol2qm74	6385	10	infusien	infusien	NNP
cord-015021-pol2qm74	6385	11	.	.	.
cord-015021-pol2qm74	6386	1	After	after	IN
cord-015021-pol2qm74	6386	2	4	4	CD
cord-015021-pol2qm74	6386	3	days	day	NNS
cord-015021-pol2qm74	6386	4	dopamine	dopamine	NN
cord-015021-pol2qm74	6386	5	requirements	requirement	NNS
cord-015021-pol2qm74	6386	6	decreased	decrease	VBD
cord-015021-pol2qm74	6386	7	to	to	IN
cord-015021-pol2qm74	6386	8	less	less	JJR
cord-015021-pol2qm74	6386	9	than	than	IN
cord-015021-pol2qm74	6386	10	2	2	CD
cord-015021-pol2qm74	6386	11	gg&g	gg&g	NNP
cord-015021-pol2qm74	6386	12	/	/	SYM
cord-015021-pol2qm74	6386	13	min	min	NN
cord-015021-pol2qm74	6386	14	in	in	IN
cord-015021-pol2qm74	6386	15	all	all	DT
cord-015021-pol2qm74	6386	16	patients	patient	NNS
cord-015021-pol2qm74	6386	17	.	.	.
cord-015021-pol2qm74	6387	1	This	this	DT
cord-015021-pol2qm74	6387	2	corresponded	correspond	VBD
cord-015021-pol2qm74	6387	3	to	to	IN
cord-015021-pol2qm74	6387	4	an	an	DT
cord-015021-pol2qm74	6387	5	attenuation	attenuation	NN
cord-015021-pol2qm74	6387	6	of	of	IN
cord-015021-pol2qm74	6387	7	the	the	DT
cord-015021-pol2qm74	6387	8	systemic	systemic	JJ
cord-015021-pol2qm74	6387	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6387	10	response	response	NN
cord-015021-pol2qm74	6387	11	syndrome	syndrome	NN
cord-015021-pol2qm74	6387	12	(	(	-LRB-
cord-015021-pol2qm74	6387	13	SIRS	SIRS	NNP
cord-015021-pol2qm74	6387	14	)	)	-RRB-
cord-015021-pol2qm74	6387	15	indicated	indicate	VBN
cord-015021-pol2qm74	6387	16	by	by	IN
cord-015021-pol2qm74	6387	17	the	the	DT
cord-015021-pol2qm74	6387	18	abrogation	abrogation	NN
cord-015021-pol2qm74	6387	19	of	of	IN
cord-015021-pol2qm74	6387	20	fever	fever	NN
cord-015021-pol2qm74	6387	21	and	and	CC
cord-015021-pol2qm74	6387	22	the	the	DT
cord-015021-pol2qm74	6387	23	decrease	decrease	NN
cord-015021-pol2qm74	6387	24	in	in	IN
cord-015021-pol2qm74	6387	25	heart	heart	NN
cord-015021-pol2qm74	6387	26	rate	rate	NN
cord-015021-pol2qm74	6387	27	and	and	CC
cord-015021-pol2qm74	6387	28	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6387	29	mediators	mediator	NNS
cord-015021-pol2qm74	6387	30	.	.	.
cord-015021-pol2qm74	6388	1	PLA	PLA	NNP
cord-015021-pol2qm74	6388	2	2	2	CD
cord-015021-pol2qm74	6388	3	activity	activity	NN
cord-015021-pol2qm74	6388	4	and	and	CC
cord-015021-pol2qm74	6388	5	E	e	NN
cord-015021-pol2qm74	6388	6	-	-	JJ
cord-015021-pol2qm74	6388	7	PI	pi	JJ
cord-015021-pol2qm74	6388	8	concentrations	concentration	NNS
cord-015021-pol2qm74	6388	9	decreased	decrease	VBD
cord-015021-pol2qm74	6388	10	to	to	IN
cord-015021-pol2qm74	6388	11	near	near	IN
cord-015021-pol2qm74	6388	12	normal	normal	JJ
cord-015021-pol2qm74	6388	13	values	value	NNS
cord-015021-pol2qm74	6388	14	and	and	CC
cord-015021-pol2qm74	6388	15	CRP	crp	NN
cord-015021-pol2qm74	6388	16	concentrations	concentration	NNS
cord-015021-pol2qm74	6388	17	decreased	decrease	VBD
cord-015021-pol2qm74	6388	18	as	as	RB
cord-015021-pol2qm74	6388	19	well	well	RB
cord-015021-pol2qm74	6388	20	.	.	.
cord-015021-pol2qm74	6389	1	After	after	IN
cord-015021-pol2qm74	6389	2	cessation	cessation	NN
cord-015021-pol2qm74	6389	3	of	of	IN
cord-015021-pol2qm74	6389	4	HC	HC	NNP
cord-015021-pol2qm74	6389	5	infusion	infusion	NN
cord-015021-pol2qm74	6389	6	(	(	-LRB-
cord-015021-pol2qm74	6389	7	between	between	IN
cord-015021-pol2qm74	6389	8	day	day	NN
cord-015021-pol2qm74	6389	9	5	5	CD
cord-015021-pol2qm74	6389	10	and	and	CC
cord-015021-pol2qm74	6389	11	7	7	CD
cord-015021-pol2qm74	6389	12	)	)	-RRB-
cord-015021-pol2qm74	6389	13	a	a	DT
cord-015021-pol2qm74	6389	14	reinforcement	reinforcement	NN
cord-015021-pol2qm74	6389	15	nfthe	nfthe	JJS
cord-015021-pol2qm74	6389	16	SIRS	SIRS	NNP
cord-015021-pol2qm74	6389	17	was	be	VBD
cord-015021-pol2qm74	6389	18	observed	observe	VBN
cord-015021-pol2qm74	6389	19	despite	despite	IN
cord-015021-pol2qm74	6389	20	cortisol	cortisol	NN
cord-015021-pol2qm74	6389	21	levels	level	NNS
cord-015021-pol2qm74	6389	22	within	within	IN
cord-015021-pol2qm74	6389	23	the	the	DT
cord-015021-pol2qm74	6389	24	normal	normal	JJ
cord-015021-pol2qm74	6389	25	range	range	NN
cord-015021-pol2qm74	6389	26	.	.	.
cord-015021-pol2qm74	6390	1	This	this	DT
cord-015021-pol2qm74	6390	2	was	be	VBD
cord-015021-pol2qm74	6390	3	first	first	RB
cord-015021-pol2qm74	6390	4	indicated	indicate	VBN
cord-015021-pol2qm74	6390	5	by	by	IN
cord-015021-pol2qm74	6390	6	E	e	NN
cord-015021-pol2qm74	6390	7	-	-	NN
cord-015021-pol2qm74	6390	8	PI	pi	NN
cord-015021-pol2qm74	6390	9	,	,	,
cord-015021-pol2qm74	6390	10	followed	follow	VBN
cord-015021-pol2qm74	6390	11	by	by	IN
cord-015021-pol2qm74	6390	12	fever	fever	NN
cord-015021-pol2qm74	6390	13	,	,	,
cord-015021-pol2qm74	6390	14	increases	increase	NNS
cord-015021-pol2qm74	6390	15	in	in	IN
cord-015021-pol2qm74	6390	16	heart	heart	NN
cord-015021-pol2qm74	6390	17	rate	rate	NN
cord-015021-pol2qm74	6390	18	,	,	,
cord-015021-pol2qm74	6390	19	CRP	CRP	NNP
cord-015021-pol2qm74	6390	20	,	,	,
cord-015021-pol2qm74	6390	21	PLA2	PLA2	NNP
cord-015021-pol2qm74	6390	22	,	,	,
cord-015021-pol2qm74	6390	23	and	and	CC
cord-015021-pol2qm74	6390	24	finally	finally	RB
cord-015021-pol2qm74	6390	25	by	by	IN
cord-015021-pol2qm74	6390	26	the	the	DT
cord-015021-pol2qm74	6390	27	relapse	relapse	NN
cord-015021-pol2qm74	6390	28	of	of	IN
cord-015021-pol2qm74	6390	29	septic	septic	JJ
cord-015021-pol2qm74	6390	30	shock	shock	NN
cord-015021-pol2qm74	6390	31	in	in	IN
cord-015021-pol2qm74	6390	32	four	four	CD
cord-015021-pol2qm74	6390	33	patients	patient	NNS
cord-015021-pol2qm74	6390	34	on	on	IN
cord-015021-pol2qm74	6390	35	days	day	NNS
cord-015021-pol2qm74	6390	36	7,8	7,8	CD
cord-015021-pol2qm74	6390	37	9	9	CD
cord-015021-pol2qm74	6390	38	,	,	,
cord-015021-pol2qm74	6390	39	and	and	CC
cord-015021-pol2qm74	6390	40	1O.	1o.	CD
cord-015021-pol2qm74	6390	41	A	a	DT
cord-015021-pol2qm74	6390	42	second	second	JJ
cord-015021-pol2qm74	6390	43	infusion	infusion	NN
cord-015021-pol2qm74	6390	44	of	of	IN
cord-015021-pol2qm74	6390	45	HC	HC	NNP
cord-015021-pol2qm74	6390	46	again	again	RB
cord-015021-pol2qm74	6390	47	resulted	result	VBD
cord-015021-pol2qm74	6390	48	in	in	IN
cord-015021-pol2qm74	6390	49	shock	shock	NN
cord-015021-pol2qm74	6390	50	reversal	reversal	NN
cord-015021-pol2qm74	6390	51	and	and	CC
cord-015021-pol2qm74	6390	52	in	in	IN
cord-015021-pol2qm74	6390	53	a	a	DT
cord-015021-pol2qm74	6390	54	decrease	decrease	NN
cord-015021-pol2qm74	6390	55	in	in	IN
cord-015021-pol2qm74	6390	56	PLA2	PLA2	NNP
cord-015021-pol2qm74	6390	57	,	,	,
cord-015021-pol2qm74	6390	58	CRP	CRP	NNP
cord-015021-pol2qm74	6390	59	,	,	,
cord-015021-pol2qm74	6390	60	and	and	CC
cord-015021-pol2qm74	6390	61	E	e	NN
cord-015021-pol2qm74	6390	62	-	-	NN
cord-015021-pol2qm74	6390	63	PI	pi	NN
cord-015021-pol2qm74	6390	64	in	in	IN
cord-015021-pol2qm74	6390	65	the	the	DT
cord-015021-pol2qm74	6390	66	patients	patient	NNS
cord-015021-pol2qm74	6390	67	under	under	IN
cord-015021-pol2qm74	6390	68	study	study	NN
cord-015021-pol2qm74	6390	69	.	.	.
cord-015021-pol2qm74	6391	1	Discussion	discussion	NN
cord-015021-pol2qm74	6391	2	:	:	:
cord-015021-pol2qm74	6392	1	There	there	EX
cord-015021-pol2qm74	6392	2	is	be	VBZ
cord-015021-pol2qm74	6392	3	growing	grow	VBG
cord-015021-pol2qm74	6392	4	evidence	evidence	NN
cord-015021-pol2qm74	6392	5	that	that	IN
cord-015021-pol2qm74	6392	6	the	the	DT
cord-015021-pol2qm74	6392	7	endogenous	endogenous	JJ
cord-015021-pol2qm74	6392	8	steroid	steroid	NN
cord-015021-pol2qm74	6392	9	HC	hc	NN
cord-015021-pol2qm74	6392	10	and	and	CC
cord-015021-pol2qm74	6392	11	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	6392	12	cytokines	cytokine	NNS
cord-015021-pol2qm74	6392	13	integrate	integrate	VBP
cord-015021-pol2qm74	6392	14	a	a	DT
cord-015021-pol2qm74	6392	15	complex	complex	JJ
cord-015021-pol2qm74	6392	16	immunoregulatory	immunoregulatory	NN
cord-015021-pol2qm74	6392	17	feec	feec	NNP
cord-015021-pol2qm74	6392	18	~	~	NFP
cord-015021-pol2qm74	6392	19	ack	ack	NNP
cord-015021-pol2qm74	6392	20	circuit	circuit	NN
cord-015021-pol2qm74	6392	21	.	.	.
cord-015021-pol2qm74	6393	1	The	the	DT
cord-015021-pol2qm74	6393	2	elaboration	elaboration	NN
cord-015021-pol2qm74	6393	3	of	of	IN
cord-015021-pol2qm74	6393	4	TNF	TNF	NNP
cord-015021-pol2qm74	6393	5	,	,	,
cord-015021-pol2qm74	6393	6	IL-16	IL-16	NNP
cord-015021-pol2qm74	6393	7	,	,	,
cord-015021-pol2qm74	6393	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	6393	9	,	,	,
cord-015021-pol2qm74	6393	10	and	and	CC
cord-015021-pol2qm74	6393	11	IL-8	IL-8	NNP
cord-015021-pol2qm74	6393	12	is	be	VBZ
cord-015021-pol2qm74	6393	13	attenuated	attenuate	VBN
cord-015021-pol2qm74	6393	14	by-100	by-100	NNP
cord-015021-pol2qm74	6393	15	rag	rag	NN
cord-015021-pol2qm74	6393	16	HC	HC	NNP
cord-015021-pol2qm74	6393	17	prior	prior	RB
cord-015021-pol2qm74	6393	18	to	to	IN
cord-015021-pol2qm74	6393	19	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6393	20	challenge	challenge	NN
cord-015021-pol2qm74	6393	21	in	in	IN
cord-015021-pol2qm74	6393	22	humans	human	NNS
cord-015021-pol2qm74	6393	23	(	(	-LRB-
cord-015021-pol2qm74	6393	24	2	2	CD
cord-015021-pol2qm74	6393	25	,	,	,
cord-015021-pol2qm74	6393	26	3	3	CD
cord-015021-pol2qm74	6393	27	)	)	-RRB-
cord-015021-pol2qm74	6393	28	.	.	.
cord-015021-pol2qm74	6394	1	Cytokines	Cytokines	NNP
cord-015021-pol2qm74	6394	2	like	like	IN
cord-015021-pol2qm74	6394	3	TNF	TNF	NNP
cord-015021-pol2qm74	6394	4	,	,	,
cord-015021-pol2qm74	6394	5	IL-16	IL-16	NNP
cord-015021-pol2qm74	6394	6	,	,	,
cord-015021-pol2qm74	6394	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	6394	8	,	,	,
cord-015021-pol2qm74	6394	9	and	and	CC
cord-015021-pol2qm74	6394	10	IL-8	IL-8	NNP
cord-015021-pol2qm74	6394	11	are	be	VBP
cord-015021-pol2qm74	6394	12	potent	potent	JJ
cord-015021-pol2qm74	6394	13	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	6394	14	signals	signal	NNS
cord-015021-pol2qm74	6394	15	for	for	IN
cord-015021-pol2qm74	6394	16	acute	acute	JJ
cord-015021-pol2qm74	6394	17	reactants	reactant	NNS
cord-015021-pol2qm74	6394	18	(	(	-LRB-
cord-015021-pol2qm74	6394	19	--	--	:
cord-015021-pol2qm74	6394	20	,	,	,
cord-015021-pol2qm74	6394	21	CLIP	CLIP	NNP
cord-015021-pol2qm74	6394	22	)	)	-RRB-
cord-015021-pol2qm74	6394	23	,	,	,
cord-015021-pol2qm74	6394	24	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6394	25	degranulation	degranulation	NN
cord-015021-pol2qm74	6394	26	(	(	-LRB-
cord-015021-pol2qm74	6394	27	--	--	:
cord-015021-pol2qm74	6394	28	,	,	,
cord-015021-pol2qm74	6394	29	E	e	NN
cord-015021-pol2qm74	6394	30	-	-	NN
cord-015021-pol2qm74	6394	31	PI	PI	NNP
cord-015021-pol2qm74	6394	32	)	)	-RRB-
cord-015021-pol2qm74	6394	33	,	,	,
cord-015021-pol2qm74	6394	34	and	and	CC
cord-015021-pol2qm74	6394	35	PLA	PLA	NNP
cord-015021-pol2qm74	6394	36	2	2	CD
cord-015021-pol2qm74	6394	37	synthesis	synthesis	NN
cord-015021-pol2qm74	6394	38	and	and	CC
cord-015021-pol2qm74	6394	39	secretion	secretion	NN
cord-015021-pol2qm74	6394	40	.	.	.
cord-015021-pol2qm74	6395	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	6395	2	data	datum	NNS
cord-015021-pol2qm74	6395	3	provide	provide	VBP
cord-015021-pol2qm74	6395	4	evidence	evidence	NN
cord-015021-pol2qm74	6395	5	that	that	IN
cord-015021-pol2qm74	6395	6	HC	HC	NNP
cord-015021-pol2qm74	6395	7	at	at	IN
cord-015021-pol2qm74	6395	8	an	an	DT
cord-015021-pol2qm74	6395	9	infusion	infusion	NN
cord-015021-pol2qm74	6395	10	rate	rate	NN
cord-015021-pol2qm74	6395	11	similar	similar	JJ
cord-015021-pol2qm74	6395	12	to	to	IN
cord-015021-pol2qm74	6395	13	the	the	DT
cord-015021-pol2qm74	6395	14	maximal	maximal	JJ
cord-015021-pol2qm74	6395	15	secretory	secretory	JJ
cord-015021-pol2qm74	6395	16	rate	rate	NN
cord-015021-pol2qm74	6395	17	of	of	IN
cord-015021-pol2qm74	6395	18	cortisol	cortisol	NN
cord-015021-pol2qm74	6395	19	in	in	IN
cord-015021-pol2qm74	6395	20	man	man	NN
cord-015021-pol2qm74	6395	21	attenuates	attenuate	VBZ
cord-015021-pol2qm74	6395	22	the	the	DT
cord-015021-pol2qm74	6395	23	systemic	systemic	JJ
cord-015021-pol2qm74	6395	24	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6395	25	response	response	NN
cord-015021-pol2qm74	6395	26	in	in	IN
cord-015021-pol2qm74	6395	27	human	human	JJ
cord-015021-pol2qm74	6395	28	septic	septic	JJ
cord-015021-pol2qm74	6395	29	shock	shock	NN
cord-015021-pol2qm74	6395	30	.	.	.
cord-015021-pol2qm74	6396	1	To	to	TO
cord-015021-pol2qm74	6396	2	evaluate	evaluate	VB
cord-015021-pol2qm74	6396	3	the	the	DT
cord-015021-pol2qm74	6396	4	feasibility	feasibility	NN
cord-015021-pol2qm74	6396	5	of	of	IN
cord-015021-pol2qm74	6396	6	a	a	DT
cord-015021-pol2qm74	6396	7	nigh	nigh	JJ
cord-015021-pol2qm74	6396	8	-	-	HYPH
cord-015021-pol2qm74	6396	9	dose	dose	NN
cord-015021-pol2qm74	6396	10	regimen	regimen	NN
cord-015021-pol2qm74	6396	11	of	of	IN
cord-015021-pol2qm74	6396	12	antithrombin	antithrombin	NN
cord-015021-pol2qm74	6396	13	III	III	NNP
cord-015021-pol2qm74	6396	14	(	(	-LRB-
cord-015021-pol2qm74	6396	15	AT	at	IN
cord-015021-pol2qm74	6396	16	III	III	NNP
cord-015021-pol2qm74	6396	17	)	)	-RRB-
cord-015021-pol2qm74	6396	18	treatment	treatment	NN
cord-015021-pol2qm74	6396	19	in	in	IN
cord-015021-pol2qm74	6396	20	patients	patient	NNS
cord-015021-pol2qm74	6396	21	with	with	IN
cord-015021-pol2qm74	6396	22	multiple	multiple	JJ
cord-015021-pol2qm74	6396	23	injuries	injury	NNS
cord-015021-pol2qm74	6396	24	regarding	regard	VBG
cord-015021-pol2qm74	6396	25	blood	blood	NN
cord-015021-pol2qm74	6396	26	levels	level	NNS
cord-015021-pol2qm74	6396	27	of	of	IN
cord-015021-pol2qm74	6396	28	antithrombin	antithrombin	NN
cord-015021-pol2qm74	6396	29	III	III	NNP
cord-015021-pol2qm74	6396	30	and	and	CC
cord-015021-pol2qm74	6396	31	undesired	undesired	JJ
cord-015021-pol2qm74	6396	32	side	side	NN
cord-015021-pol2qm74	6396	33	effcts	effct	NNS
cord-015021-pol2qm74	6396	34	and	and	CC
cord-015021-pol2qm74	6396	35	to	to	TO
cord-015021-pol2qm74	6396	36	analyse	analyse	VB
cord-015021-pol2qm74	6396	37	effects	effect	NNS
cord-015021-pol2qm74	6396	38	of	of	IN
cord-015021-pol2qm74	6396	39	the	the	DT
cord-015021-pol2qm74	6396	40	initibitortherapy	initibitortherapy	NN
cord-015021-pol2qm74	6396	41	on	on	IN
cord-015021-pol2qm74	6396	42	the	the	DT
cord-015021-pol2qm74	6396	43	systemic	systemic	JJ
cord-015021-pol2qm74	6396	44	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6396	45	response	response	NN
cord-015021-pol2qm74	6396	46	.	.	.
cord-015021-pol2qm74	6397	1	Patients	patient	NNS
cord-015021-pol2qm74	6397	2	and	and	CC
cord-015021-pol2qm74	6397	3	methods	method	NNS
cord-015021-pol2qm74	6397	4	:	:	:
cord-015021-pol2qm74	6397	5	20	20	CD
cord-015021-pol2qm74	6397	6	patients	patient	NNS
cord-015021-pol2qm74	6397	7	with	with	IN
cord-015021-pol2qm74	6397	8	an	an	DT
cord-015021-pol2qm74	6397	9	ISS	ISS	NNP
cord-015021-pol2qm74	6397	10	nf	nf	NN
cord-015021-pol2qm74	6397	11	more	more	JJR
cord-015021-pol2qm74	6397	12	than	than	IN
cord-015021-pol2qm74	6397	13	28	28	CD
cord-015021-pol2qm74	6397	14	points	point	NNS
cord-015021-pol2qm74	6397	15	who	who	WP
cord-015021-pol2qm74	6397	16	could	could	MD
cord-015021-pol2qm74	6397	17	be	be	VB
cord-015021-pol2qm74	6397	18	treated	treat	VBN
cord-015021-pol2qm74	6397	19	with	with	IN
cord-015021-pol2qm74	6397	20	AT	AT	NNP
cord-015021-pol2qm74	6397	21	III	III	NNP
cord-015021-pol2qm74	6397	22	administration	administration	NN
cord-015021-pol2qm74	6397	23	within	within	IN
cord-015021-pol2qm74	6397	24	180	180	CD
cord-015021-pol2qm74	6397	25	rain	rain	NN
cord-015021-pol2qm74	6397	26	after	after	IN
cord-015021-pol2qm74	6397	27	trauma	trauma	NN
cord-015021-pol2qm74	6397	28	were	be	VBD
cord-015021-pol2qm74	6397	29	randomized	randomize	VBN
cord-015021-pol2qm74	6397	30	to	to	TO
cord-015021-pol2qm74	6397	31	receive	receive	VB
cord-015021-pol2qm74	6397	32	either	either	CC
cord-015021-pol2qm74	6397	33	AT	AT	NNP
cord-015021-pol2qm74	6397	34	III	iii	CD
cord-015021-pol2qm74	6397	35	or	or	CC
cord-015021-pol2qm74	6397	36	placebo	placebo	NN
cord-015021-pol2qm74	6397	37	.	.	.
cord-015021-pol2qm74	6398	1	AT	at	IN
cord-015021-pol2qm74	6398	2	III	III	NNP
cord-015021-pol2qm74	6398	3	was	be	VBD
cord-015021-pol2qm74	6398	4	given	give	VBN
cord-015021-pol2qm74	6398	5	to	to	TO
cord-015021-pol2qm74	6398	6	reach	reach	VB
cord-015021-pol2qm74	6398	7	an	an	DT
cord-015021-pol2qm74	6398	8	antithrombin	antithrombin	NN
cord-015021-pol2qm74	6398	9	III	iii	CD
cord-015021-pol2qm74	6398	10	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	6398	11	capacity	capacity	NN
cord-015021-pol2qm74	6398	12	in	in	IN
cord-015021-pol2qm74	6398	13	plasma	plasma	NN
cord-015021-pol2qm74	6398	14	of	of	IN
cord-015021-pol2qm74	6398	15	140	140	CD
cord-015021-pol2qm74	6398	16	%	%	NN
cord-015021-pol2qm74	6398	17	by	by	IN
cord-015021-pol2qm74	6398	18	using	use	VBG
cord-015021-pol2qm74	6398	19	the	the	DT
cord-015021-pol2qm74	6398	20	following	follow	VBG
cord-015021-pol2qm74	6398	21	calculation	calculation	NN
cord-015021-pol2qm74	6398	22	:	:	:
cord-015021-pol2qm74	6398	23	AT	at	IN
cord-015021-pol2qm74	6398	24	III	III	NNP
cord-015021-pol2qm74	6398	25	to	to	TO
cord-015021-pol2qm74	6398	26	administer	administer	VB
cord-015021-pol2qm74	6398	27	=	=	NFP
cord-015021-pol2qm74	6398	28	(	(	-LRB-
cord-015021-pol2qm74	6398	29	140	140	CD
cord-015021-pol2qm74	6398	30	%	%	NN
cord-015021-pol2qm74	6398	31	-AT	-AT	HYPH
cord-015021-pol2qm74	6398	32	III	iii	CD
cord-015021-pol2qm74	6398	33	measured	measure	VBN
cord-015021-pol2qm74	6398	34	)	)	-RRB-
cord-015021-pol2qm74	6399	1	x	x	SYM
cord-015021-pol2qm74	6399	2	body	body	NN
cord-015021-pol2qm74	6399	3	weight	weight	NN
cord-015021-pol2qm74	6399	4	.	.	.
cord-015021-pol2qm74	6400	1	AT	at	IN
cord-015021-pol2qm74	6400	2	III	III	NNP
cord-015021-pol2qm74	6400	3	was	be	VBD
cord-015021-pol2qm74	6400	4	given	give	VBN
cord-015021-pol2qm74	6400	5	every	every	DT
cord-015021-pol2qm74	6400	6	six	six	CD
cord-015021-pol2qm74	6400	7	hours	hour	NNS
cord-015021-pol2qm74	6400	8	for	for	IN
cord-015021-pol2qm74	6400	9	a	a	DT
cord-015021-pol2qm74	6400	10	period	period	NN
cord-015021-pol2qm74	6400	11	nf48	nf48	RB
cord-015021-pol2qm74	6400	12	hours	hour	NNS
cord-015021-pol2qm74	6400	13	and	and	CC
cord-015021-pol2qm74	6400	14	on	on	IN
cord-015021-pol2qm74	6400	15	the	the	DT
cord-015021-pol2qm74	6400	16	4th	4th	JJ
cord-015021-pol2qm74	6400	17	day	day	NN
cord-015021-pol2qm74	6400	18	.	.	.
cord-015021-pol2qm74	6401	1	Patients	patient	NNS
cord-015021-pol2qm74	6401	2	were	be	VBD
cord-015021-pol2qm74	6401	3	followed	follow	VBN
cord-015021-pol2qm74	6401	4	up	up	RP
cord-015021-pol2qm74	6401	5	throughout	throughout	IN
cord-015021-pol2qm74	6401	6	their	-PRON-	PRP$
cord-015021-pol2qm74	6401	7	stay	stay	NN
cord-015021-pol2qm74	6401	8	in	in	IN
cord-015021-pol2qm74	6401	9	the	the	DT
cord-015021-pol2qm74	6401	10	ICU	ICU	NNP
cord-015021-pol2qm74	6402	1	but	but	CC
cord-015021-pol2qm74	6402	2	at	at	RB
cord-015021-pol2qm74	6402	3	least	least	RBS
cord-015021-pol2qm74	6402	4	14	14	CD
cord-015021-pol2qm74	6402	5	days	day	NNS
cord-015021-pol2qm74	6402	6	.	.	.
cord-015021-pol2qm74	6403	1	In	in	IN
cord-015021-pol2qm74	6403	2	this	this	DT
cord-015021-pol2qm74	6403	3	abstract	abstract	JJ
cord-015021-pol2qm74	6403	4	the	the	DT
cord-015021-pol2qm74	6403	5	data	datum	NNS
cord-015021-pol2qm74	6403	6	of	of	IN
cord-015021-pol2qm74	6403	7	the	the	DT
cord-015021-pol2qm74	6403	8	first	first	JJ
cord-015021-pol2qm74	6403	9	10	10	CD
cord-015021-pol2qm74	6403	10	patients	patient	NNS
cord-015021-pol2qm74	6403	11	are	be	VBP
cord-015021-pol2qm74	6403	12	included	include	VBN
cord-015021-pol2qm74	6403	13	.	.	.
cord-015021-pol2qm74	6404	1	Results	result	NNS
cord-015021-pol2qm74	6404	2	:	:	:
cord-015021-pol2qm74	6405	1	The	the	DT
cord-015021-pol2qm74	6405	2	patients	patient	NNS
cord-015021-pol2qm74	6405	3	'	'	POS
cord-015021-pol2qm74	6405	4	median	median	JJ
cord-015021-pol2qm74	6405	5	injury	injury	NN
cord-015021-pol2qm74	6405	6	severity	severity	NN
cord-015021-pol2qm74	6405	7	score	score	NN
cord-015021-pol2qm74	6405	8	was	be	VBD
cord-015021-pol2qm74	6405	9	41	41	CD
cord-015021-pol2qm74	6405	10	points	point	NNS
cord-015021-pol2qm74	6405	11	with	with	IN
cord-015021-pol2qm74	6405	12	a	a	DT
cord-015021-pol2qm74	6405	13	median	median	JJ
cord-015021-pol2qm74	6405	14	age	age	NN
cord-015021-pol2qm74	6405	15	of	of	IN
cord-015021-pol2qm74	6405	16	42	42	CD
cord-015021-pol2qm74	6405	17	years	year	NNS
cord-015021-pol2qm74	6405	18	.	.	.
cord-015021-pol2qm74	6406	1	The	the	DT
cord-015021-pol2qm74	6406	2	patients	patient	NNS
cord-015021-pol2qm74	6406	3	were	be	VBD
cord-015021-pol2qm74	6406	4	equally	equally	RB
cord-015021-pol2qm74	6406	5	distributed	distribute	VBN
cord-015021-pol2qm74	6406	6	between	between	IN
cord-015021-pol2qm74	6406	7	verum	verum	NN
cord-015021-pol2qm74	6406	8	and	and	CC
cord-015021-pol2qm74	6406	9	placebo	placebo	NN
cord-015021-pol2qm74	6406	10	groups	group	NNS
cord-015021-pol2qm74	6406	11	with	with	IN
cord-015021-pol2qm74	6406	12	respact	respact	NN
cord-015021-pol2qm74	6406	13	to	to	IN
cord-015021-pol2qm74	6406	14	age	age	NN
cord-015021-pol2qm74	6406	15	,	,	,
cord-015021-pol2qm74	6406	16	ISS	ISS	NNP
cord-015021-pol2qm74	6406	17	,	,	,
cord-015021-pol2qm74	6406	18	prehospital	prehospital	JJ
cord-015021-pol2qm74	6406	19	treatment	treatment	NN
cord-015021-pol2qm74	6406	20	,	,	,
cord-015021-pol2qm74	6406	21	blood	blood	NN
cord-015021-pol2qm74	6406	22	pressure	pressure	NN
cord-015021-pol2qm74	6406	23	,	,	,
cord-015021-pol2qm74	6406	24	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6406	25	and	and	CC
cord-015021-pol2qm74	6406	26	AT	at	IN
cord-015021-pol2qm74	6406	27	nMevel	nMevel	NNP
cord-015021-pol2qm74	6406	28	on	on	IN
cord-015021-pol2qm74	6406	29	admission	admission	NN
cord-015021-pol2qm74	6406	30	,	,	,
cord-015021-pol2qm74	6406	31	and	and	CC
cord-015021-pol2qm74	6406	32	time	time	NN
cord-015021-pol2qm74	6406	33	from	from	IN
cord-015021-pol2qm74	6406	34	the	the	DT
cord-015021-pol2qm74	6406	35	accident	accident	NN
cord-015021-pol2qm74	6406	36	until	until	IN
cord-015021-pol2qm74	6406	37	the	the	DT
cord-015021-pol2qm74	6406	38	test	test	NN
cord-015021-pol2qm74	6406	39	solution	solution	NN
cord-015021-pol2qm74	6406	40	was	be	VBD
cord-015021-pol2qm74	6406	41	given	give	VBN
cord-015021-pol2qm74	6406	42	.	.	.
cord-015021-pol2qm74	6407	1	The	the	DT
cord-015021-pol2qm74	6407	2	patients	patient	NNS
cord-015021-pol2qm74	6407	3	of	of	IN
cord-015021-pol2qm74	6407	4	the	the	DT
cord-015021-pol2qm74	6407	5	AT	AT	NNP
cord-015021-pol2qm74	6407	6	III	iii	CD
cord-015021-pol2qm74	6407	7	group	group	NN
cord-015021-pol2qm74	6407	8	received	receive	VBD
cord-015021-pol2qm74	6407	9	18,100	18,100	CD
cord-015021-pol2qm74	6407	10	units	unit	NNS
cord-015021-pol2qm74	6407	11	of	of	IN
cord-015021-pol2qm74	6407	12	the	the	DT
cord-015021-pol2qm74	6407	13	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6407	14	on	on	IN
cord-015021-pol2qm74	6407	15	average	average	NN
cord-015021-pol2qm74	6407	16	during	during	IN
cord-015021-pol2qm74	6407	17	the	the	DT
cord-015021-pol2qm74	6407	18	first	first	JJ
cord-015021-pol2qm74	6407	19	4	4	CD
cord-015021-pol2qm74	6407	20	days	day	NNS
cord-015021-pol2qm74	6407	21	.	.	.
cord-015021-pol2qm74	6408	1	With	with	IN
cord-015021-pol2qm74	6408	2	our	-PRON-	PRP$
cord-015021-pol2qm74	6408	3	regimen	regimen	NN
cord-015021-pol2qm74	6408	4	,	,	,
cord-015021-pol2qm74	6408	5	the	the	DT
cord-015021-pol2qm74	6408	6	AT	AT	NNP
cord-015021-pol2qm74	6408	7	III	iii	CD
cord-015021-pol2qm74	6408	8	levels	level	NNS
cord-015021-pol2qm74	6408	9	could	could	MD
cord-015021-pol2qm74	6408	10	be	be	VB
cord-015021-pol2qm74	6408	11	kept	keep	VBN
cord-015021-pol2qm74	6408	12	between	between	IN
cord-015021-pol2qm74	6408	13	125	125	CD
cord-015021-pol2qm74	6408	14	%	%	NN
cord-015021-pol2qm74	6408	15	and	and	CC
cord-015021-pol2qm74	6408	16	140	140	CD
cord-015021-pol2qm74	6408	17	%	%	NN
cord-015021-pol2qm74	6408	18	of	of	IN
cord-015021-pol2qm74	6408	19	normal	normal	JJ
cord-015021-pol2qm74	6408	20	,	,	,
cord-015021-pol2qm74	6408	21	whereas	whereas	IN
cord-015021-pol2qm74	6408	22	control	control	NN
cord-015021-pol2qm74	6408	23	patients	patient	NNS
cord-015021-pol2qm74	6408	24	an	an	DT
cord-015021-pol2qm74	6408	25	AT	AT	NNP
cord-015021-pol2qm74	6408	26	HI	HI	NNP
cord-015021-pol2qm74	6408	27	concentration	concentration	NN
cord-015021-pol2qm74	6408	28	of	of	IN
cord-015021-pol2qm74	6408	29	40	40	CD
cord-015021-pol2qm74	6408	30	%	%	NN
cord-015021-pol2qm74	6408	31	to	to	TO
cord-015021-pol2qm74	6408	32	60	60	CD
cord-015021-pol2qm74	6408	33	%	%	NN
cord-015021-pol2qm74	6408	34	was	be	VBD
cord-015021-pol2qm74	6408	35	observed	observe	VBN
cord-015021-pol2qm74	6408	36	.	.	.
cord-015021-pol2qm74	6409	1	Patients	patient	NNS
cord-015021-pol2qm74	6409	2	with	with	IN
cord-015021-pol2qm74	6409	3	AT	AT	NNP
cord-015021-pol2qm74	6409	4	nI	nI	NNP
cord-015021-pol2qm74	6409	5	treatment	treatment	NN
cord-015021-pol2qm74	6409	6	required	require	VBD
cord-015021-pol2qm74	6409	7	less	less	JJR
cord-015021-pol2qm74	6409	8	red	red	JJ
cord-015021-pol2qm74	6409	9	blood	blood	NN
cord-015021-pol2qm74	6409	10	cells	cell	NNS
cord-015021-pol2qm74	6409	11	bur	bur	NN
cord-015021-pol2qm74	6409	12	received	receive	VBD
cord-015021-pol2qm74	6409	13	the	the	DT
cord-015021-pol2qm74	6409	14	same	same	JJ
cord-015021-pol2qm74	6409	15	amount	amount	NN
cord-015021-pol2qm74	6409	16	of	of	IN
cord-015021-pol2qm74	6409	17	FFP	ffp	NN
cord-015021-pol2qm74	6409	18	and	and	CC
cord-015021-pol2qm74	6409	19	fluids	fluid	NNS
cord-015021-pol2qm74	6409	20	.	.	.
cord-015021-pol2qm74	6410	1	There	there	EX
cord-015021-pol2qm74	6410	2	were	be	VBD
cord-015021-pol2qm74	6410	3	no	no	DT
cord-015021-pol2qm74	6410	4	differences	difference	NNS
cord-015021-pol2qm74	6410	5	with	with	IN
cord-015021-pol2qm74	6410	6	respect	respect	NN
cord-015021-pol2qm74	6410	7	to	to	IN
cord-015021-pol2qm74	6410	8	platelet	platelet	NN
cord-015021-pol2qm74	6410	9	count	count	NN
cord-015021-pol2qm74	6410	10	,	,	,
cord-015021-pol2qm74	6410	11	partial	partial	JJ
cord-015021-pol2qm74	6410	12	thromboplastin	thromboplastin	NNP
cord-015021-pol2qm74	6410	13	time	time	NN
cord-015021-pol2qm74	6410	14	,	,	,
cord-015021-pol2qm74	6410	15	l	l	NNP
cord-015021-pol2qm74	6410	16	~	~	NFP
cord-015021-pol2qm74	6410	17	rothrombin	rothrombin	JJ
cord-015021-pol2qm74	6410	18	time	time	NN
cord-015021-pol2qm74	6410	19	and	and	CC
cord-015021-pol2qm74	6410	20	prothrombim	prothrombim	NNP
cord-015021-pol2qm74	6410	21	.	.	.
cord-015021-pol2qm74	6411	1	We	-PRON-	PRP
cord-015021-pol2qm74	6411	2	did	do	VBD
cord-015021-pol2qm74	6411	3	not	not	RB
cord-015021-pol2qm74	6411	4	observe	observe	VB
cord-015021-pol2qm74	6411	5	bleeding	bleed	VBG
cord-015021-pol2qm74	6411	6	disorders	disorder	NNS
cord-015021-pol2qm74	6411	7	or	or	CC
cord-015021-pol2qm74	6411	8	any	any	DT
cord-015021-pol2qm74	6411	9	other	other	JJ
cord-015021-pol2qm74	6411	10	side	side	NN
cord-015021-pol2qm74	6411	11	effect	effect	NN
cord-015021-pol2qm74	6411	12	with	with	IN
cord-015021-pol2qm74	6411	13	peak	peak	JJ
cord-015021-pol2qm74	6411	14	concetrations	concetration	NNS
cord-015021-pol2qm74	6411	15	of	of	IN
cord-015021-pol2qm74	6411	16	up	up	IN
cord-015021-pol2qm74	6411	17	to	to	TO
cord-015021-pol2qm74	6411	18	206	206	CD
cord-015021-pol2qm74	6411	19	%	%	NN
cord-015021-pol2qm74	6411	20	of	of	IN
cord-015021-pol2qm74	6411	21	normal	normal	JJ
cord-015021-pol2qm74	6411	22	.	.	.
cord-015021-pol2qm74	6412	1	White	white	JJ
cord-015021-pol2qm74	6412	2	blood	blood	NN
cord-015021-pol2qm74	6412	3	count	count	NN
cord-015021-pol2qm74	6412	4	,	,	,
cord-015021-pol2qm74	6412	5	PMN	pmn	NN
cord-015021-pol2qm74	6412	6	--	--	:
cord-015021-pol2qm74	6412	7	elastase	elastase	NN
cord-015021-pol2qm74	6412	8	,	,	,
cord-015021-pol2qm74	6412	9	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	6412	10	6	6	CD
cord-015021-pol2qm74	6412	11	and	and	CC
cord-015021-pol2qm74	6412	12	8	8	CD
cord-015021-pol2qm74	6412	13	and	and	CC
cord-015021-pol2qm74	6412	14	C	c	NN
cord-015021-pol2qm74	6412	15	-	-	HYPH
cord-015021-pol2qm74	6412	16	reactive	reactive	JJ
cord-015021-pol2qm74	6412	17	protein	protein	NN
cord-015021-pol2qm74	6412	18	tended	tend	VBD
cord-015021-pol2qm74	6412	19	to	to	TO
cord-015021-pol2qm74	6412	20	be	be	VB
cord-015021-pol2qm74	6412	21	lower	low	JJR
cord-015021-pol2qm74	6412	22	in	in	IN
cord-015021-pol2qm74	6412	23	the	the	DT
cord-015021-pol2qm74	6412	24	AT	AT	NNP
cord-015021-pol2qm74	6412	25	III	iii	CD
cord-015021-pol2qm74	6412	26	group	group	NN
cord-015021-pol2qm74	6412	27	.	.	.
cord-015021-pol2qm74	6413	1	There	there	EX
cord-015021-pol2qm74	6413	2	were	be	VBD
cord-015021-pol2qm74	6413	3	no	no	DT
cord-015021-pol2qm74	6413	4	differences	difference	NNS
cord-015021-pol2qm74	6413	5	with	with	IN
cord-015021-pol2qm74	6413	6	respect	respect	NN
cord-015021-pol2qm74	6413	7	to	to	IN
cord-015021-pol2qm74	6413	8	renal	renal	JJ
cord-015021-pol2qm74	6413	9	and	and	CC
cord-015021-pol2qm74	6413	10	hepatic	hepatic	JJ
cord-015021-pol2qm74	6413	11	function	function	NN
cord-015021-pol2qm74	6413	12	parameters	parameter	NNS
cord-015021-pol2qm74	6413	13	but	but	CC
cord-015021-pol2qm74	6413	14	the	the	DT
cord-015021-pol2qm74	6413	15	duration	duration	NN
cord-015021-pol2qm74	6413	16	od	od	NNP
cord-015021-pol2qm74	6413	17	mechanical	mechanical	JJ
cord-015021-pol2qm74	6413	18	ventilation	ventilation	NN
cord-015021-pol2qm74	6413	19	was	be	VBD
cord-015021-pol2qm74	6413	20	shorter	short	JJR
cord-015021-pol2qm74	6413	21	in	in	IN
cord-015021-pol2qm74	6413	22	the	the	DT
cord-015021-pol2qm74	6413	23	AT	AT	NNP
cord-015021-pol2qm74	6413	24	II1	II1	NNP
cord-015021-pol2qm74	6413	25	group	group	NN
cord-015021-pol2qm74	6413	26	(	(	-LRB-
cord-015021-pol2qm74	6413	27	8.5	8.5	CD
cord-015021-pol2qm74	6413	28	vs.	vs.	NN
cord-015021-pol2qm74	6413	29	15.8	15.8	CD
cord-015021-pol2qm74	6413	30	days	day	NNS
cord-015021-pol2qm74	6413	31	)	)	-RRB-
cord-015021-pol2qm74	6414	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	6414	2	:	:	:
cord-015021-pol2qm74	6415	1	We	-PRON-	PRP
cord-015021-pol2qm74	6415	2	conclude	conclude	VBP
cord-015021-pol2qm74	6415	3	that	that	IN
cord-015021-pol2qm74	6415	4	our	-PRON-	PRP$
cord-015021-pol2qm74	6415	5	treatment	treatment	NN
cord-015021-pol2qm74	6415	6	protocol	protocol	NN
cord-015021-pol2qm74	6415	7	(	(	-LRB-
cord-015021-pol2qm74	6415	8	a	a	LS
cord-015021-pol2qm74	6415	9	)	)	-RRB-
cord-015021-pol2qm74	6415	10	was	be	VBD
cord-015021-pol2qm74	6415	11	able	able	JJ
cord-015021-pol2qm74	6415	12	to	to	TO
cord-015021-pol2qm74	6415	13	restore	restore	VB
cord-015021-pol2qm74	6415	14	AT	at	IN
cord-015021-pol2qm74	6415	15	IIl	IIl	NNS
cord-015021-pol2qm74	6415	16	levels	level	NNS
cord-015021-pol2qm74	6415	17	to	to	IN
cord-015021-pol2qm74	6415	18	the	the	DT
cord-015021-pol2qm74	6415	19	desired	desire	VBN
cord-015021-pol2qm74	6415	20	range	range	NN
cord-015021-pol2qm74	6415	21	of	of	IN
cord-015021-pol2qm74	6415	22	140	140	CD
cord-015021-pol2qm74	6415	23	%	%	NN
cord-015021-pol2qm74	6415	24	,	,	,
cord-015021-pol2qm74	6415	25	(	(	-LRB-
cord-015021-pol2qm74	6415	26	b	b	NN
cord-015021-pol2qm74	6415	27	)	)	-RRB-
cord-015021-pol2qm74	6415	28	did	do	VBD
cord-015021-pol2qm74	6415	29	not	not	RB
cord-015021-pol2qm74	6415	30	lead	lead	VB
cord-015021-pol2qm74	6415	31	to	to	IN
cord-015021-pol2qm74	6415	32	coagulation	coagulation	NN
cord-015021-pol2qm74	6415	33	disorders	disorder	NNS
cord-015021-pol2qm74	6415	34	,	,	,
cord-015021-pol2qm74	6415	35	(	(	-LRB-
cord-015021-pol2qm74	6415	36	c	c	NN
cord-015021-pol2qm74	6415	37	)	)	-RRB-
cord-015021-pol2qm74	6415	38	did	do	VBD
cord-015021-pol2qm74	6415	39	not	not	RB
cord-015021-pol2qm74	6415	40	increase	increase	VB
cord-015021-pol2qm74	6415	41	transfusion	transfusion	NN
cord-015021-pol2qm74	6415	42	requirements	requirement	NNS
cord-015021-pol2qm74	6415	43	,	,	,
cord-015021-pol2qm74	6415	44	(	(	-LRB-
cord-015021-pol2qm74	6415	45	d	d	LS
cord-015021-pol2qm74	6415	46	)	)	-RRB-
cord-015021-pol2qm74	6415	47	did	do	VBD
cord-015021-pol2qm74	6415	48	not	not	RB
cord-015021-pol2qm74	6415	49	reveal	reveal	VB
cord-015021-pol2qm74	6415	50	other	other	JJ
cord-015021-pol2qm74	6415	51	undesired	undesired	JJ
cord-015021-pol2qm74	6415	52	side	side	NN
cord-015021-pol2qm74	6415	53	effects	effect	NNS
cord-015021-pol2qm74	6415	54	,	,	,
cord-015021-pol2qm74	6415	55	and	and	CC
cord-015021-pol2qm74	6415	56	(	(	-LRB-
cord-015021-pol2qm74	6415	57	e	e	NN
cord-015021-pol2qm74	6415	58	)	)	-RRB-
cord-015021-pol2qm74	6415	59	showed	show	VBD
cord-015021-pol2qm74	6415	60	a	a	DT
cord-015021-pol2qm74	6415	61	tendency	tendency	NN
cord-015021-pol2qm74	6415	62	towards	towards	IN
cord-015021-pol2qm74	6415	63	reduced	reduce	VBN
cord-015021-pol2qm74	6415	64	posttranmatic	posttranmatic	JJ
cord-015021-pol2qm74	6415	65	inflammation	inflammation	NN
cord-015021-pol2qm74	6415	66	and	and	CC
cord-015021-pol2qm74	6415	67	mechanical	mechanical	JJ
cord-015021-pol2qm74	6415	68	ventilation	ventilation	NN
cord-015021-pol2qm74	6415	69	requirements	requirement	NNS
cord-015021-pol2qm74	6415	70	Department	Department	NNP
cord-015021-pol2qm74	6415	71	of	of	IN
cord-015021-pol2qm74	6415	72	Trauma	Trauma	NNP
cord-015021-pol2qm74	6415	73	Surgery	Surgery	NNP
cord-015021-pol2qm74	6415	74	,	,	,
cord-015021-pol2qm74	6415	75	45122	45122	CD
cord-015021-pol2qm74	6415	76	Essen	Essen	NNP
cord-015021-pol2qm74	6415	77	,	,	,
cord-015021-pol2qm74	6415	78	Germany	Germany	NNP
cord-015021-pol2qm74	6415	79	Antithrombin	Antithrombin	NNP
cord-015021-pol2qm74	6415	80	-	-	HYPH
cord-015021-pol2qm74	6415	81	lll	lll	NNP
cord-015021-pol2qm74	6415	82	(	(	-LRB-
cord-015021-pol2qm74	6415	83	AT	AT	NNP
cord-015021-pol2qm74	6415	84	-	-	HYPH
cord-015021-pol2qm74	6415	85	Ill	Ill	NNP
cord-015021-pol2qm74	6415	86	)	)	-RRB-
cord-015021-pol2qm74	6415	87	acts	act	VBZ
cord-015021-pol2qm74	6415	88	as	as	IN
cord-015021-pol2qm74	6415	89	an	an	DT
cord-015021-pol2qm74	6415	90	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6415	91	of	of	IN
cord-015021-pol2qm74	6415	92	thrombin	thrombin	NN
cord-015021-pol2qm74	6415	93	,	,	,
cord-015021-pol2qm74	6415	94	further	further	JJ
cord-015021-pol2qm74	6415	95	proteases	protease	NNS
cord-015021-pol2qm74	6415	96	and	and	CC
cord-015021-pol2qm74	6415	97	the	the	DT
cord-015021-pol2qm74	6415	98	alternative	alternative	JJ
cord-015021-pol2qm74	6415	99	pathway	pathway	NN
cord-015021-pol2qm74	6415	100	of	of	IN
cord-015021-pol2qm74	6415	101	the	the	DT
cord-015021-pol2qm74	6415	102	complement	complement	JJ
cord-015021-pol2qm74	6415	103	system	system	NN
cord-015021-pol2qm74	6415	104	.	.	.
cord-015021-pol2qm74	6416	1	Inhibiting	inhibit	VBG
cord-015021-pol2qm74	6416	2	thrombin	thrombin	NN
cord-015021-pol2qm74	6416	3	,	,	,
cord-015021-pol2qm74	6416	4	AT	AT	NNP
cord-015021-pol2qm74	6416	5	-	-	HYPH
cord-015021-pol2qm74	6416	6	Ill	Ill	NNP
cord-015021-pol2qm74	6416	7	works	work	VBZ
cord-015021-pol2qm74	6416	8	as	as	IN
cord-015021-pol2qm74	6416	9	a	a	DT
cord-015021-pol2qm74	6416	10	functional	functional	JJ
cord-015021-pol2qm74	6416	11	antagonist	antagonist	NN
cord-015021-pol2qm74	6416	12	of	of	IN
cord-015021-pol2qm74	6417	1	PAF~	PAF~	NNP
cord-015021-pol2qm74	6417	2	Therefore	therefore	RB
cord-015021-pol2qm74	6417	3	,	,	,
cord-015021-pol2qm74	6417	4	in	in	IN
cord-015021-pol2qm74	6417	5	state	state	NN
cord-015021-pol2qm74	6417	6	of	of	IN
cord-015021-pol2qm74	6417	7	hypevolemic	hypevolemic	NN
cord-015021-pol2qm74	6417	8	-	-	HYPH
cord-015021-pol2qm74	6417	9	traumatic	traumatic	JJ
cord-015021-pol2qm74	6417	10	shock	shock	NN
cord-015021-pol2qm74	6417	11	,	,	,
cord-015021-pol2qm74	6417	12	continuous	continuous	JJ
cord-015021-pol2qm74	6417	13	supranormal	supranormal	JJ
cord-015021-pol2qm74	6417	14	serum	serum	NN
cord-015021-pol2qm74	6417	15	-and	-and	CC
cord-015021-pol2qm74	6417	16	tissue	tissue	NN
cord-015021-pol2qm74	6417	17	-concentrations	-concentration	NNS
cord-015021-pol2qm74	6417	18	of	of	IN
cord-015021-pol2qm74	6417	19	AT	AT	NNP
cord-015021-pol2qm74	6417	20	-	-	HYPH
cord-015021-pol2qm74	6417	21	Ill	Ill	NNP
cord-015021-pol2qm74	6417	22	may	may	MD
cord-015021-pol2qm74	6417	23	be	be	VB
cord-015021-pol2qm74	6417	24	efficient	efficient	JJ
cord-015021-pol2qm74	6417	25	to	to	TO
cord-015021-pol2qm74	6417	26	reduce	reduce	VB
cord-015021-pol2qm74	6417	27	the	the	DT
cord-015021-pol2qm74	6417	28	local	local	JJ
cord-015021-pol2qm74	6417	29	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	6417	30	reactions	reaction	NNS
cord-015021-pol2qm74	6417	31	resulting	result	VBG
cord-015021-pol2qm74	6417	32	from	from	IN
cord-015021-pol2qm74	6417	33	complement	complement	NN
cord-015021-pol2qm74	6417	34	and	and	CC
cord-015021-pol2qm74	6417	35	PMN	pmn	NN
cord-015021-pol2qm74	6417	36	-	-	HYPH
cord-015021-pol2qm74	6417	37	activation	activation	NN
cord-015021-pol2qm74	6417	38	.	.	.
cord-015021-pol2qm74	6418	1	20	20	CD
cord-015021-pol2qm74	6418	2	patients	patient	NNS
cord-015021-pol2qm74	6418	3	with	with	IN
cord-015021-pol2qm74	6418	4	severe	severe	JJ
cord-015021-pol2qm74	6418	5	multiple	multiple	JJ
cord-015021-pol2qm74	6418	6	trauma	trauma	NN
cord-015021-pol2qm74	6418	7	(	(	-LRB-
cord-015021-pol2qm74	6418	8	7	7	CD
cord-015021-pol2qm74	6418	9	treatment	treatment	NN
cord-015021-pol2qm74	6418	10	[	[	-LRB-
cord-015021-pol2qm74	6418	11	AT	AT	NNP
cord-015021-pol2qm74	6418	12	-	-	HYPH
cord-015021-pol2qm74	6418	13	Ill	Ill	NNP
cord-015021-pol2qm74	6418	14	]	]	-RRB-
cord-015021-pol2qm74	6419	1	--13	--13	NNP
cord-015021-pol2qm74	6419	2	controls	control	VBZ
cord-015021-pol2qm74	6419	3	[	[	-LRB-
cord-015021-pol2qm74	6419	4	C	C	NNP
cord-015021-pol2qm74	6419	5	]	]	-RRB-
cord-015021-pol2qm74	6419	6	)	)	-RRB-
cord-015021-pol2qm74	6419	7	were	be	VBD
cord-015021-pol2qm74	6419	8	investigated	investigate	VBN
cord-015021-pol2qm74	6419	9	.	.	.
cord-015021-pol2qm74	6420	1	Study	study	NN
cord-015021-pol2qm74	6420	2	cdteda	cdteda	NN
cord-015021-pol2qm74	6420	3	were	be	VBD
cord-015021-pol2qm74	6420	4	age	age	NN
cord-015021-pol2qm74	6421	1	>	>	XX
cord-015021-pol2qm74	6422	1	16	16	CD
cord-015021-pol2qm74	6422	2	and	and	CC
cord-015021-pol2qm74	6422	3	<	<	XX
cord-015021-pol2qm74	6422	4	65	65	CD
cord-015021-pol2qm74	6422	5	years	year	NNS
cord-015021-pol2qm74	6422	6	,	,	,
cord-015021-pol2qm74	6422	7	injury	injury	NN
cord-015021-pol2qm74	6422	8	severity	severity	NN
cord-015021-pol2qm74	6422	9	(	(	-LRB-
cord-015021-pol2qm74	6422	10	ISS	ISS	NNP
cord-015021-pol2qm74	6422	11	)	)	-RRB-
cord-015021-pol2qm74	6422	12	>	>	XX
cord-015021-pol2qm74	6423	1	30	30	CD
cord-015021-pol2qm74	6423	2	points	point	NNS
cord-015021-pol2qm74	6423	3	and	and	CC
cord-015021-pol2qm74	6423	4	Glasgow	Glasgow	NNP
cord-015021-pol2qm74	6423	5	-	-	HYPH
cord-015021-pol2qm74	6423	6	Coma	Coma	NNP
cord-015021-pol2qm74	6423	7	-	-	HYPH
cord-015021-pol2qm74	6423	8	Scale	Scale	NNP
cord-015021-pol2qm74	6423	9	>	>	SYM
cord-015021-pol2qm74	6423	10	8	8	CD
cord-015021-pol2qm74	6423	11	points	point	NNS
cord-015021-pol2qm74	6423	12	;	;	:
cord-015021-pol2qm74	6423	13	Randomization	randomization	NN
cord-015021-pol2qm74	6423	14	and	and	CC
cord-015021-pol2qm74	6423	15	treatment	treatment	NN
cord-015021-pol2qm74	6423	16	has	have	VBZ
cord-015021-pol2qm74	6423	17	to	to	TO
cord-015021-pol2qm74	6423	18	be	be	VB
cord-015021-pol2qm74	6423	19	started	start	VBN
cord-015021-pol2qm74	6423	20	within	within	IN
cord-015021-pol2qm74	6423	21	6	6	CD
cord-015021-pol2qm74	6423	22	hours	hour	NNS
cord-015021-pol2qm74	6423	23	after	after	IN
cord-015021-pol2qm74	6423	24	trauma	trauma	NN
cord-015021-pol2qm74	6423	25	.	.	.
cord-015021-pol2qm74	6424	1	Permission	permission	NN
cord-015021-pol2qm74	6424	2	for	for	IN
cord-015021-pol2qm74	6424	3	the	the	DT
cord-015021-pol2qm74	6424	4	clinical	clinical	JJ
cord-015021-pol2qm74	6424	5	study	study	NN
cord-015021-pol2qm74	6424	6	was	be	VBD
cord-015021-pol2qm74	6424	7	given	give	VBN
cord-015021-pol2qm74	6424	8	by	by	IN
cord-015021-pol2qm74	6424	9	the	the	DT
cord-015021-pol2qm74	6424	10	local	local	JJ
cord-015021-pol2qm74	6424	11	ethic	ethic	NNP
cord-015021-pol2qm74	6424	12	committee	committee	NN
cord-015021-pol2qm74	6424	13	.	.	.
cord-015021-pol2qm74	6425	1	Bradykinin	Bradykinin	NNP
cord-015021-pol2qm74	6425	2	(	(	-LRB-
cord-015021-pol2qm74	6425	3	BK	BK	NNP
cord-015021-pol2qm74	6425	4	)	)	-RRB-
cord-015021-pol2qm74	6425	5	and	and	CC
cord-015021-pol2qm74	6425	6	related	relate	VBN
cord-015021-pol2qm74	6425	7	kinins	kinin	NNS
cord-015021-pol2qm74	6425	8	are	be	VBP
cord-015021-pol2qm74	6425	9	potent	potent	JJ
cord-015021-pol2qm74	6425	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6425	11	peptides	peptide	NNS
cord-015021-pol2qm74	6425	12	which	which	WDT
cord-015021-pol2qm74	6425	13	possess	possess	VBP
cord-015021-pol2qm74	6425	14	the	the	DT
cord-015021-pol2qm74	6425	15	ability	ability	NN
cord-015021-pol2qm74	6425	16	to	to	TO
cord-015021-pol2qm74	6425	17	induce	induce	VB
cord-015021-pol2qm74	6425	18	,	,	,
cord-015021-pol2qm74	6425	19	vasodilation	vasodilation	NN
cord-015021-pol2qm74	6425	20	,	,	,
cord-015021-pol2qm74	6425	21	increased	increase	VBN
cord-015021-pol2qm74	6425	22	vascular	vascular	JJ
cord-015021-pol2qm74	6425	23	permeability	permeability	NN
cord-015021-pol2qm74	6425	24	and	and	CC
cord-015021-pol2qm74	6425	25	hyperalgesia	hyperalgesia	NN
cord-015021-pol2qm74	6425	26	.	.	.
cord-015021-pol2qm74	6426	1	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6426	2	,	,	,
cord-015021-pol2qm74	6426	3	a	a	DT
cord-015021-pol2qm74	6426	4	novel	novel	NN
cord-015021-pol2qm74	6426	5	homodimer	homodimer	VBN
cord-015021-pol2qm74	6426	6	BK	BK	NNP
cord-015021-pol2qm74	6426	7	antagonist	antagonist	NN
cord-015021-pol2qm74	6426	8	has	have	VBZ
cord-015021-pol2qm74	6426	9	previously	previously	RB
cord-015021-pol2qm74	6426	10	been	be	VBN
cord-015021-pol2qm74	6426	11	shown	show	VBN
cord-015021-pol2qm74	6426	12	to	to	TO
cord-015021-pol2qm74	6426	13	increase	increase	VB
cord-015021-pol2qm74	6426	14	survival	survival	NN
cord-015021-pol2qm74	6426	15	in	in	IN
cord-015021-pol2qm74	6426	16	rat	rat	NN
cord-015021-pol2qm74	6426	17	and	and	CC
cord-015021-pol2qm74	6426	18	rabbit	rabbit	NN
cord-015021-pol2qm74	6426	19	models	model	NNS
cord-015021-pol2qm74	6426	20	of	of	IN
cord-015021-pol2qm74	6426	21	lethal	lethal	JJ
cord-015021-pol2qm74	6426	22	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6426	23	shock	shock	NN
cord-015021-pol2qm74	6426	24	and	and	CC
cord-015021-pol2qm74	6426	25	is	be	VBZ
cord-015021-pol2qm74	6426	26	now	now	RB
cord-015021-pol2qm74	6426	27	in	in	IN
cord-015021-pol2qm74	6426	28	clinical	clinical	JJ
cord-015021-pol2qm74	6426	29	trials	trial	NNS
cord-015021-pol2qm74	6426	30	for	for	IN
cord-015021-pol2qm74	6426	31	sepsis	sepsis	NN
cord-015021-pol2qm74	6426	32	.	.	.
cord-015021-pol2qm74	6427	1	We	-PRON-	PRP
cord-015021-pol2qm74	6427	2	have	have	VBP
cord-015021-pol2qm74	6427	3	now	now	RB
cord-015021-pol2qm74	6427	4	evaluated	evaluate	VBN
cord-015021-pol2qm74	6427	5	the	the	DT
cord-015021-pol2qm74	6427	6	effect	effect	NN
cord-015021-pol2qm74	6427	7	of	of	IN
cord-015021-pol2qm74	6427	8	CP-0127	cp-0127	NN
cord-015021-pol2qm74	6427	9	in	in	IN
cord-015021-pol2qm74	6427	10	other	other	JJ
cord-015021-pol2qm74	6427	11	models	model	NNS
cord-015021-pol2qm74	6427	12	of	of	IN
cord-015021-pol2qm74	6427	13	inflammation	inflammation	NN
cord-015021-pol2qm74	6427	14	.	.	.
cord-015021-pol2qm74	6428	1	Male	male	JJ
cord-015021-pol2qm74	6428	2	rats	rat	NNS
cord-015021-pol2qm74	6428	3	were	be	VBD
cord-015021-pol2qm74	6428	4	precannulated	precannulate	VBN
cord-015021-pol2qm74	6428	5	with	with	IN
cord-015021-pol2qm74	6428	6	a	a	DT
cord-015021-pol2qm74	6428	7	catheter	catheter	NN
cord-015021-pol2qm74	6428	8	in	in	IN
cord-015021-pol2qm74	6428	9	the	the	DT
cord-015021-pol2qm74	6428	10	carotid	carotid	JJ
cord-015021-pol2qm74	6428	11	artery	artery	NN
cord-015021-pol2qm74	6428	12	.	.	.
cord-015021-pol2qm74	6429	1	24h	24h	NNP
cord-015021-pol2qm74	6429	2	later	later	RB
cord-015021-pol2qm74	6429	3	BK	BK	NNP
cord-015021-pol2qm74	6429	4	was	be	VBD
cord-015021-pol2qm74	6429	5	injected	inject	VBN
cord-015021-pol2qm74	6429	6	ia	ia	NNP
cord-015021-pol2qm74	6429	7	and	and	CC
cord-015021-pol2qm74	6429	8	the	the	DT
cord-015021-pol2qm74	6429	9	pain	pain	NN
cord-015021-pol2qm74	6429	10	score	score	NN
cord-015021-pol2qm74	6429	11	ranked	rank	VBD
cord-015021-pol2qm74	6429	12	from	from	IN
cord-015021-pol2qm74	6429	13	0	0	NFP
cord-015021-pol2qm74	6429	14	(	(	-LRB-
cord-015021-pol2qm74	6429	15	no	no	DT
cord-015021-pol2qm74	6429	16	responses	response	NNS
cord-015021-pol2qm74	6429	17	)	)	-RRB-
cord-015021-pol2qm74	6429	18	to	to	IN
cord-015021-pol2qm74	6429	19	5	5	CD
cord-015021-pol2qm74	6429	20	(	(	-LRB-
cord-015021-pol2qm74	6429	21	vocalization	vocalization	NN
cord-015021-pol2qm74	6429	22	)	)	-RRB-
cord-015021-pol2qm74	6429	23	.	.	.
cord-015021-pol2qm74	6430	1	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6430	2	at	at	IN
cord-015021-pol2qm74	6430	3	3.6	3.6	CD
cord-015021-pol2qm74	6430	4	umoles	umole	NNS
cord-015021-pol2qm74	6430	5	/	/	SYM
cord-015021-pol2qm74	6430	6	kg	kg	CC
cord-015021-pol2qm74	6430	7	completely	completely	RB
cord-015021-pol2qm74	6430	8	inhibited	inhibit	VBD
cord-015021-pol2qm74	6430	9	the	the	DT
cord-015021-pol2qm74	6430	10	pain	pain	NN
cord-015021-pol2qm74	6430	11	responses	response	NNS
cord-015021-pol2qm74	6430	12	for	for	IN
cord-015021-pol2qm74	6430	13	a	a	DT
cord-015021-pol2qm74	6430	14	period	period	NN
cord-015021-pol2qm74	6430	15	of	of	IN
cord-015021-pol2qm74	6430	16	2.5	2.5	CD
cord-015021-pol2qm74	6430	17	-3h	-3h	NNS
cord-015021-pol2qm74	6430	18	.	.	.
cord-015021-pol2qm74	6431	1	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6431	2	at	at	IN
cord-015021-pol2qm74	6431	3	3.6	3.6	CD
cord-015021-pol2qm74	6431	4	umoles	umoles	NNPS
cord-015021-pol2qm74	6431	5	/	/	SYM
cord-015021-pol2qm74	6431	6	kg	kg	NNP
cord-015021-pol2qm74	6431	7	s.c	s.c	NNP
cord-015021-pol2qm74	6431	8	.	.	NNP
cord-015021-pol2qm74	6431	9	was	be	VBD
cord-015021-pol2qm74	6431	10	also	also	RB
cord-015021-pol2qm74	6431	11	found	find	VBN
cord-015021-pol2qm74	6431	12	to	to	TO
cord-015021-pol2qm74	6431	13	inhibit	inhibit	VB
cord-015021-pol2qm74	6431	14	the	the	DT
cord-015021-pol2qm74	6431	15	increase	increase	NN
cord-015021-pol2qm74	6431	16	in	in	IN
cord-015021-pol2qm74	6431	17	paw	paw	NN
cord-015021-pol2qm74	6431	18	volume	volume	NN
cord-015021-pol2qm74	6431	19	and	and	CC
cord-015021-pol2qm74	6431	20	hyperalgesia	hyperalgesia	NN
cord-015021-pol2qm74	6431	21	induced	induce	VBN
cord-015021-pol2qm74	6431	22	in	in	IN
cord-015021-pol2qm74	6431	23	rats	rat	NNS
cord-015021-pol2qm74	6431	24	over	over	IN
cord-015021-pol2qm74	6431	25	a	a	DT
cord-015021-pol2qm74	6431	26	3	3	CD
cord-015021-pol2qm74	6431	27	-	-	HYPH
cord-015021-pol2qm74	6431	28	4h	4h	CD
cord-015021-pol2qm74	6431	29	period	period	NN
cord-015021-pol2qm74	6431	30	by	by	IN
cord-015021-pol2qm74	6431	31	an	an	DT
cord-015021-pol2qm74	6431	32	intraplantar	intraplantar	JJ
cord-015021-pol2qm74	6431	33	injection	injection	NN
cord-015021-pol2qm74	6431	34	of	of	IN
cord-015021-pol2qm74	6431	35	0.1	0.1	CD
cord-015021-pol2qm74	6431	36	%	%	NN
cord-015021-pol2qm74	6431	37	carrageenan	carrageenan	NN
cord-015021-pol2qm74	6431	38	.	.	.
cord-015021-pol2qm74	6432	1	The	the	DT
cord-015021-pol2qm74	6432	2	abdominal	abdominal	JJ
cord-015021-pol2qm74	6432	3	constriction	constriction	NN
cord-015021-pol2qm74	6432	4	response	response	NN
cord-015021-pol2qm74	6432	5	1o	1o	CD
cord-015021-pol2qm74	6433	1	an	an	DT
cord-015021-pol2qm74	6433	2	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	6433	3	injection	injection	NN
cord-015021-pol2qm74	6433	4	of	of	IN
cord-015021-pol2qm74	6433	5	kaolin	kaolin	NN
cord-015021-pol2qm74	6433	6	was	be	VBD
cord-015021-pol2qm74	6433	7	inhibited	inhibit	VBN
cord-015021-pol2qm74	6433	8	in	in	IN
cord-015021-pol2qm74	6433	9	a	a	DT
cord-015021-pol2qm74	6433	10	dose	dose	NN
cord-015021-pol2qm74	6433	11	-	-	HYPH
cord-015021-pol2qm74	6433	12	dependent	dependent	JJ
cord-015021-pol2qm74	6433	13	manner	manner	NN
cord-015021-pol2qm74	6433	14	by	by	IN
cord-015021-pol2qm74	6433	15	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6433	16	.	.	.
cord-015021-pol2qm74	6434	1	When	when	WRB
cord-015021-pol2qm74	6434	2	50	50	CD
cord-015021-pol2qm74	6434	3	ul	ul	NN
cord-015021-pol2qm74	6434	4	of	of	IN
cord-015021-pol2qm74	6434	5	0.5	0.5	CD
cord-015021-pol2qm74	6434	6	%	%	NN
cord-015021-pol2qm74	6434	7	formalin	formalin	NN
cord-015021-pol2qm74	6434	8	was	be	VBD
cord-015021-pol2qm74	6434	9	injected	inject	VBN
cord-015021-pol2qm74	6434	10	into	into	IN
cord-015021-pol2qm74	6434	11	the	the	DT
cord-015021-pol2qm74	6434	12	paw	paw	NN
cord-015021-pol2qm74	6434	13	of	of	IN
cord-015021-pol2qm74	6434	14	a	a	DT
cord-015021-pol2qm74	6434	15	mouse	mouse	NN
cord-015021-pol2qm74	6434	16	a	a	DT
cord-015021-pol2qm74	6434	17	characteristic	characteristic	JJ
cord-015021-pol2qm74	6434	18	licking	lick	VBG
cord-015021-pol2qm74	6434	19	response	response	NN
cord-015021-pol2qm74	6434	20	was	be	VBD
cord-015021-pol2qm74	6434	21	observed	observe	VBN
cord-015021-pol2qm74	6434	22	which	which	WDT
cord-015021-pol2qm74	6434	23	was	be	VBD
cord-015021-pol2qm74	6434	24	biphasic	biphasic	JJ
cord-015021-pol2qm74	6434	25	in	in	IN
cord-015021-pol2qm74	6434	26	nature	nature	NN
cord-015021-pol2qm74	6434	27	.	.	.
cord-015021-pol2qm74	6435	1	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6435	2	significantly	significantly	RB
cord-015021-pol2qm74	6435	3	inhibited	inhibit	VBD
cord-015021-pol2qm74	6435	4	both	both	CC
cord-015021-pol2qm74	6435	5	the	the	DT
cord-015021-pol2qm74	6435	6	first	first	JJ
cord-015021-pol2qm74	6435	7	(	(	-LRB-
cord-015021-pol2qm74	6435	8	0	0	CD
cord-015021-pol2qm74	6435	9	-	-	HYPH
cord-015021-pol2qm74	6435	10	5min	5min	CD
cord-015021-pol2qm74	6435	11	)	)	-RRB-
cord-015021-pol2qm74	6435	12	and	and	CC
cord-015021-pol2qm74	6435	13	second	second	JJ
cord-015021-pol2qm74	6435	14	(	(	-LRB-
cord-015021-pol2qm74	6435	15	15	15	CD
cord-015021-pol2qm74	6435	16	-	-	SYM
cord-015021-pol2qm74	6435	17	30	30	CD
cord-015021-pol2qm74	6435	18	min	min	NN
cord-015021-pol2qm74	6435	19	)	)	-RRB-
cord-015021-pol2qm74	6435	20	phase	phase	NN
cord-015021-pol2qm74	6435	21	responses	response	NNS
cord-015021-pol2qm74	6435	22	.	.	.
cord-015021-pol2qm74	6435	23	]	]	-RRB-
cord-015021-pol2qm74	6436	1	n	n	LS
cord-015021-pol2qm74	6436	2	a	a	DT
cord-015021-pol2qm74	6436	3	rat	rat	NN
cord-015021-pol2qm74	6436	4	burn	burn	NN
cord-015021-pol2qm74	6436	5	model	model	NN
cord-015021-pol2qm74	6436	6	,	,	,
cord-015021-pol2qm74	6436	7	where	where	WRB
cord-015021-pol2qm74	6436	8	the	the	DT
cord-015021-pol2qm74	6436	9	hind	hind	NN
cord-015021-pol2qm74	6436	10	paw	paw	NNP
cord-015021-pol2qm74	6436	11	is	be	VBZ
cord-015021-pol2qm74	6436	12	immersed	immerse	VBN
cord-015021-pol2qm74	6436	13	in	in	IN
cord-015021-pol2qm74	6436	14	water	water	NN
cord-015021-pol2qm74	6436	15	at	at	IN
cord-015021-pol2qm74	6436	16	55	55	CD
cord-015021-pol2qm74	6436	17	°	°	NN
cord-015021-pol2qm74	6436	18	C	c	NN
cord-015021-pol2qm74	6436	19	for	for	IN
cord-015021-pol2qm74	6436	20	15	15	CD
cord-015021-pol2qm74	6436	21	sec	sec	NNP
cord-015021-pol2qm74	6437	1	the	the	DT
cord-015021-pol2qm74	6437	2	increase	increase	NN
cord-015021-pol2qm74	6437	3	in	in	IN
cord-015021-pol2qm74	6437	4	paw	paw	NN
cord-015021-pol2qm74	6437	5	volume	volume	NN
cord-015021-pol2qm74	6437	6	was	be	VBD
cord-015021-pol2qm74	6437	7	significantly	significantly	RB
cord-015021-pol2qm74	6437	8	reduced	reduce	VBN
cord-015021-pol2qm74	6437	9	by	by	IN
cord-015021-pol2qm74	6437	10	pretreatment	pretreatment	NN
cord-015021-pol2qm74	6437	11	with	with	IN
cord-015021-pol2qm74	6437	12	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6437	13	,	,	,
cord-015021-pol2qm74	6437	14	3.6	3.6	CD
cord-015021-pol2qm74	6437	15	umoles	umoles	NNPS
cord-015021-pol2qm74	6437	16	/	/	SYM
cord-015021-pol2qm74	6437	17	kg	kg	NNP
cord-015021-pol2qm74	6437	18	s.c	s.c	NNP
cord-015021-pol2qm74	6437	19	.	.	.
cord-015021-pol2qm74	6438	1	Finally	finally	RB
cord-015021-pol2qm74	6438	2	cerebrai	cerebrai	NNP
cord-015021-pol2qm74	6438	3	edema	edema	NN
cord-015021-pol2qm74	6438	4	was	be	VBD
cord-015021-pol2qm74	6438	5	induced	induce	VBN
cord-015021-pol2qm74	6438	6	in	in	IN
cord-015021-pol2qm74	6438	7	rats	rat	NNS
cord-015021-pol2qm74	6438	8	by	by	IN
cord-015021-pol2qm74	6438	9	applying	apply	VBG
cord-015021-pol2qm74	6438	10	cold	cold	JJ
cord-015021-pol2qm74	6438	11	(	(	-LRB-
cord-015021-pol2qm74	6438	12	-78	-78	NN
cord-015021-pol2qm74	6438	13	°	°	NN
cord-015021-pol2qm74	6438	14	C	c	NN
cord-015021-pol2qm74	6438	15	for	for	IN
cord-015021-pol2qm74	6438	16	10	10	CD
cord-015021-pol2qm74	6438	17	sec	sec	NNP
cord-015021-pol2qm74	6438	18	)	)	-RRB-
cord-015021-pol2qm74	6438	19	to	to	IN
cord-015021-pol2qm74	6438	20	the	the	DT
cord-015021-pol2qm74	6438	21	dural	dural	NN
cord-015021-pol2qm74	6438	22	surface	surface	NN
cord-015021-pol2qm74	6438	23	following	follow	VBG
cord-015021-pol2qm74	6438	24	a	a	DT
cord-015021-pol2qm74	6438	25	craniectomy	craniectomy	NN
cord-015021-pol2qm74	6438	26	.	.	.
cord-015021-pol2qm74	6439	1	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6439	2	at	at	IN
cord-015021-pol2qm74	6439	3	3.6	3.6	CD
cord-015021-pol2qm74	6439	4	umoles	umoles	NNPS
cord-015021-pol2qm74	6439	5	/	/	SYM
cord-015021-pol2qm74	6439	6	kg	kg	NNP
cord-015021-pol2qm74	6439	7	s.c	s.c	NNP
cord-015021-pol2qm74	6439	8	.	.	NNP
cord-015021-pol2qm74	6439	9	produced	produce	VBD
cord-015021-pol2qm74	6439	10	a	a	DT
cord-015021-pol2qm74	6439	11	significant	significant	JJ
cord-015021-pol2qm74	6439	12	reduction	reduction	NN
cord-015021-pol2qm74	6439	13	in	in	IN
cord-015021-pol2qm74	6439	14	the	the	DT
cord-015021-pol2qm74	6439	15	amount	amount	NN
cord-015021-pol2qm74	6439	16	of	of	IN
cord-015021-pol2qm74	6439	17	edema	edema	NN
cord-015021-pol2qm74	6439	18	compared	compare	VBN
cord-015021-pol2qm74	6439	19	with	with	IN
cord-015021-pol2qm74	6439	20	sham	sham	NN
cord-015021-pol2qm74	6439	21	controls	control	VBZ
cord-015021-pol2qm74	6439	22	24	24	CD
cord-015021-pol2qm74	6439	23	h	h	NNP
cord-015021-pol2qm74	6439	24	later	later	RB
cord-015021-pol2qm74	6439	25	.	.	.
cord-015021-pol2qm74	6440	1	These	these	DT
cord-015021-pol2qm74	6440	2	data	datum	NNS
cord-015021-pol2qm74	6440	3	suggest	suggest	VBP
cord-015021-pol2qm74	6440	4	that	that	IN
cord-015021-pol2qm74	6440	5	BK	BK	NNP
cord-015021-pol2qm74	6440	6	is	be	VBZ
cord-015021-pol2qm74	6440	7	an	an	DT
cord-015021-pol2qm74	6440	8	important	important	JJ
cord-015021-pol2qm74	6440	9	mediator	mediator	NN
cord-015021-pol2qm74	6440	10	of	of	IN
cord-015021-pol2qm74	6440	11	inflammation	inflammation	NN
cord-015021-pol2qm74	6440	12	and	and	CC
cord-015021-pol2qm74	6440	13	hyperalgesia	hyperalgesia	NN
cord-015021-pol2qm74	6440	14	and	and	CC
cord-015021-pol2qm74	6440	15	that	that	IN
cord-015021-pol2qm74	6440	16	the	the	DT
cord-015021-pol2qm74	6440	17	bradykinin	bradykinin	NN
cord-015021-pol2qm74	6440	18	antagonist	antagonist	NN
cord-015021-pol2qm74	6440	19	,	,	,
cord-015021-pol2qm74	6440	20	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	6440	21	,	,	,
cord-015021-pol2qm74	6440	22	may	may	MD
cord-015021-pol2qm74	6440	23	be	be	VB
cord-015021-pol2qm74	6440	24	useful	useful	JJ
cord-015021-pol2qm74	6440	25	in	in	IN
cord-015021-pol2qm74	6440	26	the	the	DT
cord-015021-pol2qm74	6440	27	treatment	treatment	NN
cord-015021-pol2qm74	6440	28	of	of	IN
cord-015021-pol2qm74	6440	29	such	such	JJ
cord-015021-pol2qm74	6440	30	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6440	31	,	,	,
cord-015021-pol2qm74	6440	32	hyperalgesic	hyperalgesic	NN
cord-015021-pol2qm74	6440	33	disorders	disorder	NNS
cord-015021-pol2qm74	6440	34	.	.	.
cord-015021-pol2qm74	6441	1	Partial	partial	JJ
cord-015021-pol2qm74	6441	2	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	6441	3	in	in	IN
cord-015021-pol2qm74	6441	4	humans	human	NNS
cord-015021-pol2qm74	6441	5	is	be	VBZ
cord-015021-pol2qm74	6441	6	associated	associate	VBN
cord-015021-pol2qm74	6441	7	with	with	IN
cord-015021-pol2qm74	6441	8	a	a	DT
cord-015021-pol2qm74	6441	9	considerable	considerable	JJ
cord-015021-pol2qm74	6441	10	morbidity	morbidity	NN
cord-015021-pol2qm74	6441	11	due	due	IN
cord-015021-pol2qm74	6441	12	to	to	IN
cord-015021-pol2qm74	6441	13	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	6441	14	and	and	CC
cord-015021-pol2qm74	6441	15	metabolic	metabolic	JJ
cord-015021-pol2qm74	6441	16	derangements	derangement	NNS
cord-015021-pol2qm74	6441	17	,	,	,
cord-015021-pol2qm74	6441	18	which	which	WDT
cord-015021-pol2qm74	6441	19	increase	increase	VBP
cord-015021-pol2qm74	6441	20	the	the	DT
cord-015021-pol2qm74	6441	21	risk	risk	NN
cord-015021-pol2qm74	6441	22	for	for	IN
cord-015021-pol2qm74	6441	23	organ	organ	NN
cord-015021-pol2qm74	6441	24	failure	failure	NN
cord-015021-pol2qm74	6441	25	and	and	CC
cord-015021-pol2qm74	6441	26	mortality	mortality	NN
cord-015021-pol2qm74	6441	27	.	.	.
cord-015021-pol2qm74	6442	1	We	-PRON-	PRP
cord-015021-pol2qm74	6442	2	hypothesized	hypothesize	VBD
cord-015021-pol2qm74	6442	3	that	that	IN
cord-015021-pol2qm74	6442	4	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	6442	5	may	may	MD
cord-015021-pol2qm74	6442	6	play	play	VB
cord-015021-pol2qm74	6442	7	a	a	DT
cord-015021-pol2qm74	6442	8	pivotal	pivotal	JJ
cord-015021-pol2qm74	6442	9	role	role	NN
cord-015021-pol2qm74	6442	10	in	in	IN
cord-015021-pol2qm74	6442	11	these	these	DT
cord-015021-pol2qm74	6442	12	complications	complication	NNS
cord-015021-pol2qm74	6442	13	.	.	.
cord-015021-pol2qm74	6443	1	We	-PRON-	PRP
cord-015021-pol2qm74	6443	2	therefore	therefore	RB
cord-015021-pol2qm74	6443	3	,	,	,
cord-015021-pol2qm74	6443	4	investigated	investigate	VBD
cord-015021-pol2qm74	6443	5	whether	whether	IN
cord-015021-pol2qm74	6443	6	peri	peri	JJ
cord-015021-pol2qm74	6443	7	-	-	HYPH
cord-015021-pol2qm74	6443	8	operative	operative	JJ
cord-015021-pol2qm74	6443	9	infusion	infusion	NN
cord-015021-pol2qm74	6443	10	of	of	IN
cord-015021-pol2qm74	6443	11	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	6443	12	,	,	,
cord-015021-pol2qm74	6443	13	a	a	DT
cord-015021-pol2qm74	6443	14	recombinant	recombinant	JJ
cord-015021-pol2qm74	6443	15	protein	protein	NN
cord-015021-pol2qm74	6443	16	of	of	IN
cord-015021-pol2qm74	6443	17	the	the	DT
cord-015021-pol2qm74	6443	18	human	human	JJ
cord-015021-pol2qm74	6443	19	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6443	20	BPI	BPI	NNP
cord-015021-pol2qm74	6443	21	with	with	IN
cord-015021-pol2qm74	6443	22	bactericidal	bactericidal	JJ
cord-015021-pol2qm74	6443	23	and	and	CC
cord-015021-pol2qm74	6443	24	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6443	25	-	-	HYPH
cord-015021-pol2qm74	6443	26	binding	bind	VBG
cord-015021-pol2qm74	6443	27	capacity	capacity	NN
cord-015021-pol2qm74	6443	28	,	,	,
cord-015021-pol2qm74	6443	29	could	could	MD
cord-015021-pol2qm74	6443	30	prevent	prevent	VB
cord-015021-pol2qm74	6443	31	postoperative	postoperative	JJ
cord-015021-pol2qm74	6443	32	derangements	derangement	NNS
cord-015021-pol2qm74	6443	33	following	follow	VBG
cord-015021-pol2qm74	6443	34	partial	partial	JJ
cord-015021-pol2qm74	6443	35	hepatectomy	hepatectomy	NN
cord-015021-pol2qm74	6443	36	.	.	.
cord-015021-pol2qm74	6444	1	Male	male	JJ
cord-015021-pol2qm74	6444	2	Wistar	Wistar	NNP
cord-015021-pol2qm74	6444	3	rats	rat	NNS
cord-015021-pol2qm74	6444	4	(	(	-LRB-
cord-015021-pol2qm74	6444	5	230	230	CD
cord-015021-pol2qm74	6444	6	-	-	SYM
cord-015021-pol2qm74	6444	7	250	250	CD
cord-015021-pol2qm74	6444	8	g.	g.	NNP
cord-015021-pol2qm74	6444	9	)	)	-RRB-
cord-015021-pol2qm74	6444	10	received	receive	VBD
cord-015021-pol2qm74	6444	11	a	a	DT
cord-015021-pol2qm74	6444	12	70	70	CD
cord-015021-pol2qm74	6444	13	%	%	NN
cord-015021-pol2qm74	6444	14	liver	liver	NN
cord-015021-pol2qm74	6444	15	resection	resection	NN
cord-015021-pol2qm74	6444	16	(	(	-LRB-
cord-015021-pol2qm74	6444	17	phx	phx	NNP
cord-015021-pol2qm74	6444	18	)	)	-RRB-
cord-015021-pol2qm74	6444	19	or	or	CC
cord-015021-pol2qm74	6444	20	a	a	DT
cord-015021-pol2qm74	6444	21	sham	sham	JJ
cord-015021-pol2qm74	6444	22	operation	operation	NN
cord-015021-pol2qm74	6444	23	(	(	-LRB-
cord-015021-pol2qm74	6444	24	sh	sh	NNP
cord-015021-pol2qm74	6444	25	)	)	-RRB-
cord-015021-pol2qm74	6444	26	,	,	,
cord-015021-pol2qm74	6444	27	and	and	CC
cord-015021-pol2qm74	6444	28	a	a	DT
cord-015021-pol2qm74	6444	29	continuous	continuous	JJ
cord-015021-pol2qm74	6444	30	intravenous	intravenous	JJ
cord-015021-pol2qm74	6444	31	infusion	infusion	NN
cord-015021-pol2qm74	6444	32	of	of	IN
cord-015021-pol2qm74	6444	33	either	either	DT
cord-015021-pol2qm74	6444	34	0.2	0.2	CD
cord-015021-pol2qm74	6444	35	mg	mg	NNP
cord-015021-pol2qm74	6444	36	/	/	SYM
cord-015021-pol2qm74	6444	37	kg	kg	NNP
cord-015021-pol2qm74	6444	38	/	/	SYM
cord-015021-pol2qm74	6444	39	hr	hr	NN
cord-015021-pol2qm74	6445	1	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	6445	2	(	(	-LRB-
cord-015021-pol2qm74	6445	3	phx	phx	NNP
cord-015021-pol2qm74	6445	4	-	-	HYPH
cord-015021-pol2qm74	6445	5	bpi	bpi	NNP
cord-015021-pol2qm74	6445	6	,	,	,
cord-015021-pol2qm74	6445	7	n=8	n=8	NN
cord-015021-pol2qm74	6445	8	;	;	:
cord-015021-pol2qm74	6445	9	sh	sh	NNP
cord-015021-pol2qm74	6445	10	-	-	HYPH
cord-015021-pol2qm74	6445	11	bpi	bpi	NNP
cord-015021-pol2qm74	6445	12	,	,	,
cord-015021-pol2qm74	6445	13	n=7	n=7	NNS
cord-015021-pol2qm74	6445	14	)	)	-RRB-
cord-015021-pol2qm74	6445	15	or	or	CC
cord-015021-pol2qm74	6445	16	the	the	DT
cord-015021-pol2qm74	6445	17	(	(	-LRB-
cord-015021-pol2qm74	6445	18	iso	iso	JJ
cord-015021-pol2qm74	6445	19	-	-	HYPH
cord-015021-pol2qm74	6445	20	electric	electric	JJ
cord-015021-pol2qm74	6446	1	,	,	,
cord-015021-pol2qm74	6446	2	iso	iso	NNP
cord-015021-pol2qm74	6446	3	-	-	HYPH
cord-015021-pol2qm74	6446	4	kD	kd	JJ
cord-015021-pol2qm74	6446	5	)	)	-RRB-
cord-015021-pol2qm74	6446	6	control	control	NN
cord-015021-pol2qm74	6446	7	protein	protein	NN
cord-015021-pol2qm74	6446	8	thaumatin	thaumatin	NNP
cord-015021-pol2qm74	6446	9	(	(	-LRB-
cord-015021-pol2qm74	6446	10	phx	phx	NNP
cord-015021-pol2qm74	6446	11	-	-	HYPH
cord-015021-pol2qm74	6446	12	con	con	NNP
cord-015021-pol2qm74	6446	13	,	,	,
cord-015021-pol2qm74	6446	14	n=8	n=8	NN
cord-015021-pol2qm74	6446	15	;	;	:
cord-015021-pol2qm74	6446	16	sh	sh	NN
cord-015021-pol2qm74	6446	17	-	-	HYPH
cord-015021-pol2qm74	6446	18	con	con	NN
cord-015021-pol2qm74	6446	19	,	,	,
cord-015021-pol2qm74	6446	20	n-8	n-8	NNP
cord-015021-pol2qm74	6446	21	)	)	-RRB-
cord-015021-pol2qm74	6446	22	.	.	.
cord-015021-pol2qm74	6447	1	Various	various	JJ
cord-015021-pol2qm74	6447	2	parameters	parameter	NNS
cord-015021-pol2qm74	6447	3	were	be	VBD
cord-015021-pol2qm74	6447	4	measured	measure	VBN
cord-015021-pol2qm74	6447	5	4	4	CD
cord-015021-pol2qm74	6447	6	h	h	NN
cord-015021-pol2qm74	6447	7	after	after	IN
cord-015021-pol2qm74	6447	8	the	the	DT
cord-015021-pol2qm74	6447	9	resection	resection	NN
cord-015021-pol2qm74	6447	10	or	or	CC
cord-015021-pol2qm74	6447	11	sham	sham	NN
cord-015021-pol2qm74	6447	12	operation	operation	NN
cord-015021-pol2qm74	6447	13	.	.	.
cord-015021-pol2qm74	6448	1	Mean	mean	JJ
cord-015021-pol2qm74	6448	2	arterial	arterial	JJ
cord-015021-pol2qm74	6448	3	pressure	pressure	NN
cord-015021-pol2qm74	6448	4	,	,	,
cord-015021-pol2qm74	6448	5	cardiac	cardiac	JJ
cord-015021-pol2qm74	6448	6	output	output	NN
cord-015021-pol2qm74	6448	7	and	and	CC
cord-015021-pol2qm74	6448	8	heart	heart	NN
cord-015021-pol2qm74	6448	9	rate	rate	NN
cord-015021-pol2qm74	6448	10	were	be	VBD
cord-015021-pol2qm74	6448	11	significantly	significantly	RB
cord-015021-pol2qm74	6448	12	decreased	decrease	VBN
cord-015021-pol2qm74	6448	13	in	in	IN
cord-015021-pol2qm74	6448	14	phx	phx	NNP
cord-015021-pol2qm74	6448	15	-	-	HYPH
cord-015021-pol2qm74	6448	16	con	con	NN
cord-015021-pol2qm74	6448	17	rats	rat	NNS
cord-015021-pol2qm74	6448	18	compared	compare	VBN
cord-015021-pol2qm74	6448	19	with	with	IN
cord-015021-pol2qm74	6448	20	sh	sh	NNP
cord-015021-pol2qm74	6448	21	rats	rat	NNS
cord-015021-pol2qm74	6448	22	,	,	,
cord-015021-pol2qm74	6448	23	which	which	WDT
cord-015021-pol2qm74	6448	24	effects	effect	NNS
cord-015021-pol2qm74	6448	25	were	be	VBD
cord-015021-pol2qm74	6448	26	not	not	RB
cord-015021-pol2qm74	6448	27	observed	observe	VBN
cord-015021-pol2qm74	6448	28	in	in	IN
cord-015021-pol2qm74	6448	29	phx	phx	NNP
cord-015021-pol2qm74	6448	30	rats	rat	NNS
cord-015021-pol2qm74	6448	31	treated	treat	VBN
cord-015021-pol2qm74	6448	32	with	with	IN
cord-015021-pol2qm74	6448	33	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	6448	34	.	.	.
cord-015021-pol2qm74	6449	1	Blood	blood	NN
cord-015021-pol2qm74	6449	2	pH	pH	NNP
cord-015021-pol2qm74	6449	3	was	be	VBD
cord-015021-pol2qm74	6449	4	significantly	significantly	RB
cord-015021-pol2qm74	6449	5	decreased	decrease	VBN
cord-015021-pol2qm74	6449	6	in	in	IN
cord-015021-pol2qm74	6449	7	the	the	DT
cord-015021-pol2qm74	6449	8	phx	phx	NNP
cord-015021-pol2qm74	6449	9	-	-	HYPH
cord-015021-pol2qm74	6449	10	eon	eon	NNP
cord-015021-pol2qm74	6449	11	group	group	NN
cord-015021-pol2qm74	6449	12	,	,	,
cord-015021-pol2qm74	6449	13	whereas	whereas	IN
cord-015021-pol2qm74	6449	14	the	the	DT
cord-015021-pol2qm74	6449	15	leucocyte	leucocyte	NNP
cord-015021-pol2qm74	6449	16	count	count	NNP
cord-015021-pol2qm74	6449	17	,	,	,
cord-015021-pol2qm74	6449	18	hematocrite	hematocrite	NNP
cord-015021-pol2qm74	6449	19	and	and	CC
cord-015021-pol2qm74	6449	20	IL-6	IL-6	NNP
cord-015021-pol2qm74	6449	21	levels	level	NNS
cord-015021-pol2qm74	6449	22	were	be	VBD
cord-015021-pol2qm74	6449	23	significantly	significantly	RB
cord-015021-pol2qm74	6449	24	increased	increase	VBN
cord-015021-pol2qm74	6449	25	compared	compare	VBN
cord-015021-pol2qm74	6449	26	to	to	IN
cord-015021-pol2qm74	6449	27	sham	sham	JJ
cord-015021-pol2qm74	6449	28	levels	level	NNS
cord-015021-pol2qm74	6449	29	.	.	.
cord-015021-pol2qm74	6450	1	In	in	IN
cord-015021-pol2qm74	6450	2	the	the	DT
cord-015021-pol2qm74	6450	3	phx	phx	NNP
cord-015021-pol2qm74	6450	4	-	-	HYPH
cord-015021-pol2qm74	6450	5	bpi	bpi	NNP
cord-015021-pol2qm74	6450	6	group	group	NN
cord-015021-pol2qm74	6450	7	,	,	,
cord-015021-pol2qm74	6450	8	these	these	DT
cord-015021-pol2qm74	6450	9	parameters	parameter	NNS
cord-015021-pol2qm74	6450	10	were	be	VBD
cord-015021-pol2qm74	6450	11	restored	restore	VBN
cord-015021-pol2qm74	6450	12	to	to	IN
cord-015021-pol2qm74	6450	13	near	near	IN
cord-015021-pol2qm74	6450	14	sham	sham	JJ
cord-015021-pol2qm74	6450	15	levels	level	NNS
cord-015021-pol2qm74	6450	16	.	.	.
cord-015021-pol2qm74	6451	1	In	in	IN
cord-015021-pol2qm74	6451	2	vitro	vitro	FW
cord-015021-pol2qm74	6451	3	experiments	experiment	NNS
cord-015021-pol2qm74	6451	4	with	with	IN
cord-015021-pol2qm74	6451	5	rat	rat	NN
cord-015021-pol2qm74	6451	6	plasma	plasma	NN
cord-015021-pol2qm74	6451	7	and	and	CC
cord-015021-pol2qm74	6451	8	human	human	JJ
cord-015021-pol2qm74	6451	9	mononuclear	mononuclear	NN
cord-015021-pol2qm74	6451	10	cells	cell	NNS
cord-015021-pol2qm74	6451	11	(	(	-LRB-
cord-015021-pol2qm74	6451	12	MNCs	mnc	NNS
cord-015021-pol2qm74	6451	13	)	)	-RRB-
cord-015021-pol2qm74	6451	14	revealed	reveal	VBD
cord-015021-pol2qm74	6451	15	that	that	IN
cord-015021-pol2qm74	6451	16	plasma	plasma	NN
cord-015021-pol2qm74	6451	17	of	of	IN
cord-015021-pol2qm74	6451	18	phx	phx	NNP
cord-015021-pol2qm74	6451	19	-	-	HYPH
cord-015021-pol2qm74	6451	20	con	con	NN
cord-015021-pol2qm74	6451	21	rats	rat	NNS
cord-015021-pol2qm74	6451	22	is	be	VBZ
cord-015021-pol2qm74	6451	23	highly	highly	RB
cord-015021-pol2qm74	6451	24	capable	capable	JJ
cord-015021-pol2qm74	6451	25	of	of	IN
cord-015021-pol2qm74	6451	26	activating	activate	VBG
cord-015021-pol2qm74	6451	27	MNCs	mnc	NNS
cord-015021-pol2qm74	6451	28	,	,	,
cord-015021-pol2qm74	6451	29	accompanied	accompany	VBN
cord-015021-pol2qm74	6451	30	by	by	IN
cord-015021-pol2qm74	6451	31	the	the	DT
cord-015021-pol2qm74	6451	32	release	release	NN
cord-015021-pol2qm74	6451	33	of	of	IN
cord-015021-pol2qm74	6451	34	cytokines	cytokine	NNS
cord-015021-pol2qm74	6451	35	.	.	.
cord-015021-pol2qm74	6452	1	This	this	DT
cord-015021-pol2qm74	6452	2	activation	activation	NN
cord-015021-pol2qm74	6452	3	is	be	VBZ
cord-015021-pol2qm74	6452	4	attenuated	attenuate	VBN
cord-015021-pol2qm74	6452	5	with	with	IN
cord-015021-pol2qm74	6452	6	phx	phx	NNP
cord-015021-pol2qm74	6452	7	-	-	HYPH
cord-015021-pol2qm74	6452	8	bpi	bpi	NNP
cord-015021-pol2qm74	6452	9	plasma	plasma	NN
cord-015021-pol2qm74	6452	10	.	.	.
cord-015021-pol2qm74	6453	1	In	in	IN
cord-015021-pol2qm74	6453	2	vitro	vitro	FW
cord-015021-pol2qm74	6453	3	added	add	VBN
cord-015021-pol2qm74	6453	4	aCD14	aCD14	NNP
cord-015021-pol2qm74	6453	5	or	or	CC
cord-015021-pol2qm74	6453	6	polymyxin	polymyxin	NN
cord-015021-pol2qm74	6453	7	B	B	NNP
cord-015021-pol2qm74	6453	8	was	be	VBD
cord-015021-pol2qm74	6453	9	able	able	JJ
cord-015021-pol2qm74	6453	10	to	to	TO
cord-015021-pol2qm74	6453	11	reduce	reduce	VB
cord-015021-pol2qm74	6453	12	the	the	DT
cord-015021-pol2qm74	6453	13	activation	activation	NN
cord-015021-pol2qm74	6453	14	by	by	IN
cord-015021-pol2qm74	6453	15	phx	phx	NNP
cord-015021-pol2qm74	6453	16	-	-	HYPH
cord-015021-pol2qm74	6453	17	con	con	FW
cord-015021-pol2qm74	6453	18	rat	rat	NN
cord-015021-pol2qm74	6453	19	plasma	plasma	NN
cord-015021-pol2qm74	6453	20	to	to	IN
cord-015021-pol2qm74	6453	21	the	the	DT
cord-015021-pol2qm74	6453	22	levels	level	NNS
cord-015021-pol2qm74	6453	23	of	of	IN
cord-015021-pol2qm74	6453	24	phx	phx	NNP
cord-015021-pol2qm74	6453	25	-	-	HYPH
cord-015021-pol2qm74	6453	26	bpi	bpi	NNP
cord-015021-pol2qm74	6453	27	rats	rat	NNS
cord-015021-pol2qm74	6454	1	Thus	thus	RB
cord-015021-pol2qm74	6454	2	,	,	,
cord-015021-pol2qm74	6454	3	these	these	DT
cord-015021-pol2qm74	6454	4	data	datum	NNS
cord-015021-pol2qm74	6454	5	suggest	suggest	VBP
cord-015021-pol2qm74	6454	6	that	that	IN
cord-015021-pol2qm74	6454	7	systemic	systemic	JJ
cord-015021-pol2qm74	6454	8	endctoxemia	endctoxemia	NN
cord-015021-pol2qm74	6454	9	,	,	,
cord-015021-pol2qm74	6454	10	possibly	possibly	RB
cord-015021-pol2qm74	6454	11	of	of	IN
cord-015021-pol2qm74	6454	12	gut	gut	NN
cord-015021-pol2qm74	6454	13	origin	origin	NN
cord-015021-pol2qm74	6454	14	,	,	,
cord-015021-pol2qm74	6454	15	is	be	VBZ
cord-015021-pol2qm74	6454	16	a	a	DT
cord-015021-pol2qm74	6454	17	major	major	JJ
cord-015021-pol2qm74	6454	18	cause	cause	NN
cord-015021-pol2qm74	6454	19	of	of	IN
cord-015021-pol2qm74	6454	20	postoperative	postoperative	JJ
cord-015021-pol2qm74	6454	21	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	6454	22	and	and	CC
cord-015021-pol2qm74	6454	23	metabolic	metabolic	JJ
cord-015021-pol2qm74	6454	24	derangements	derangement	NNS
cord-015021-pol2qm74	6454	25	following	follow	VBG
cord-015021-pol2qm74	6454	26	phx	phx	NNP
cord-015021-pol2qm74	6454	27	and	and	CC
cord-015021-pol2qm74	6454	28	that	that	IN
cord-015021-pol2qm74	6454	29	rBPIzz	rBPIzz	NNS
cord-015021-pol2qm74	6454	30	can	can	MD
cord-015021-pol2qm74	6454	31	prevent	prevent	VB
cord-015021-pol2qm74	6454	32	these	these	DT
cord-015021-pol2qm74	6454	33	changes	change	NNS
cord-015021-pol2qm74	6454	34	.	.	.
cord-015021-pol2qm74	6455	1	More	more	RBR
cord-015021-pol2qm74	6455	2	recently	recently	RB
cord-015021-pol2qm74	6455	3	we	-PRON-	PRP
cord-015021-pol2qm74	6455	4	reported	report	VBD
cord-015021-pol2qm74	6455	5	a	a	DT
cord-015021-pol2qm74	6455	6	transient	transient	JJ
cord-015021-pol2qm74	6455	7	appearance	appearance	NN
cord-015021-pol2qm74	6455	8	of	of	IN
cord-015021-pol2qm74	6455	9	both	both	DT
cord-015021-pol2qm74	6455	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6455	11	and	and	CC
cord-015021-pol2qm74	6455	12	TNF	TNF	NNP
cord-015021-pol2qm74	6455	13	in	in	IN
cord-015021-pol2qm74	6455	14	the	the	DT
cord-015021-pol2qm74	6455	15	circulation	circulation	NN
cord-015021-pol2qm74	6455	16	of	of	IN
cord-015021-pol2qm74	6455	17	rats	rat	NNS
cord-015021-pol2qm74	6455	18	subjected	subject	VBN
cord-015021-pol2qm74	6455	19	to	to	IN
cord-015021-pol2qm74	6455	20	the	the	DT
cord-015021-pol2qm74	6455	21	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	6455	22	shock	shock	NN
cord-015021-pol2qm74	6455	23	(	(	-LRB-
cord-015021-pol2qm74	6455	24	HS	HS	NNP
cord-015021-pol2qm74	6455	25	)	)	-RRB-
cord-015021-pol2qm74	6455	26	already	already	RB
cord-015021-pol2qm74	6455	27	at	at	IN
cord-015021-pol2qm74	6455	28	90	90	CD
cord-015021-pol2qm74	6455	29	-120	-120	NN
cord-015021-pol2qm74	6455	30	rain	rain	NN
cord-015021-pol2qm74	6455	31	.	.	.
cord-015021-pol2qm74	6456	1	Similar	similar	JJ
cord-015021-pol2qm74	6456	2	to	to	IN
cord-015021-pol2qm74	6456	3	BPI	BPI	NNP
cord-015021-pol2qm74	6456	4	,	,	,
cord-015021-pol2qm74	6456	5	recombinant	recombinant	JJ
cord-015021-pol2qm74	6456	6	BPI	BPI	NNP
cord-015021-pol2qm74	6456	7	was	be	VBD
cord-015021-pol2qm74	6456	8	found	find	VBN
cord-015021-pol2qm74	6456	9	to	to	TO
cord-015021-pol2qm74	6456	10	bind	bind	VB
cord-015021-pol2qm74	6456	11	LPS	LPS	NNP
cord-015021-pol2qm74	6456	12	and	and	CC
cord-015021-pol2qm74	6456	13	inhibit	inhibit	VB
cord-015021-pol2qm74	6456	14	TNF	TNF	NNP
cord-015021-pol2qm74	6456	15	formation	formation	NN
cord-015021-pol2qm74	6456	16	in	in	IN
cord-015021-pol2qm74	6456	17	vitro	vitro	FW
cord-015021-pol2qm74	6456	18	.	.	.
cord-015021-pol2qm74	6457	1	The	the	DT
cord-015021-pol2qm74	6457	2	aim	aim	NN
cord-015021-pol2qm74	6457	3	of	of	IN
cord-015021-pol2qm74	6457	4	this	this	DT
cord-015021-pol2qm74	6457	5	study	study	NN
cord-015021-pol2qm74	6457	6	was	be	VBD
cord-015021-pol2qm74	6457	7	to	to	TO
cord-015021-pol2qm74	6457	8	investigate	investigate	VB
cord-015021-pol2qm74	6457	9	the	the	DT
cord-015021-pol2qm74	6457	10	effects	effect	NNS
cord-015021-pol2qm74	6457	11	of	of	IN
cord-015021-pol2qm74	6457	12	rBPI21	rBPI21	NNP
cord-015021-pol2qm74	6457	13	(	(	-LRB-
cord-015021-pol2qm74	6457	14	kindly	kindly	RB
cord-015021-pol2qm74	6457	15	provided	provide	VBN
cord-015021-pol2qm74	6457	16	by	by	IN
cord-015021-pol2qm74	6457	17	Xoma	Xoma	NNP
cord-015021-pol2qm74	6457	18	corporation	corporation	NN
cord-015021-pol2qm74	6457	19	,	,	,
cord-015021-pol2qm74	6457	20	Berkeley	Berkeley	NNP
cord-015021-pol2qm74	6457	21	,	,	,
cord-015021-pol2qm74	6457	22	CA	CA	NNP
cord-015021-pol2qm74	6457	23	)	)	-RRB-
cord-015021-pol2qm74	6457	24	against	against	IN
cord-015021-pol2qm74	6457	25	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	6457	26	related	relate	VBN
cord-015021-pol2qm74	6457	27	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	6457	28	and	and	CC
cord-015021-pol2qm74	6457	29	mortality	mortality	NN
cord-015021-pol2qm74	6457	30	in	in	IN
cord-015021-pol2qm74	6457	31	rats	rat	NNS
cord-015021-pol2qm74	6457	32	.	.	.
cord-015021-pol2qm74	6458	1	Method	method	NN
cord-015021-pol2qm74	6458	2	:	:	:
cord-015021-pol2qm74	6459	1	A	a	DT
cord-015021-pol2qm74	6459	2	prolonged	prolonged	JJ
cord-015021-pol2qm74	6459	3	HS	hs	NN
cord-015021-pol2qm74	6459	4	was	be	VBD
cord-015021-pol2qm74	6459	5	induced	induce	VBN
cord-015021-pol2qm74	6459	6	by	by	IN
cord-015021-pol2qm74	6459	7	blood	blood	NN
cord-015021-pol2qm74	6459	8	withdrawal	withdrawal	NN
cord-015021-pol2qm74	6459	9	to	to	IN
cord-015021-pol2qm74	6459	10	a	a	DT
cord-015021-pol2qm74	6459	11	mean	mean	JJ
cord-015021-pol2qm74	6459	12	arterial	arterial	JJ
cord-015021-pol2qm74	6459	13	pressure	pressure	NN
cord-015021-pol2qm74	6459	14	of	of	IN
cord-015021-pol2qm74	6459	15	30	30	CD
cord-015021-pol2qm74	6459	16	-	-	SYM
cord-015021-pol2qm74	6459	17	35	35	CD
cord-015021-pol2qm74	6459	18	mmHg	mmHg	NNS
cord-015021-pol2qm74	6459	19	for	for	IN
cord-015021-pol2qm74	6459	20	180	180	CD
cord-015021-pol2qm74	6459	21	rain	rain	NN
cord-015021-pol2qm74	6459	22	followed	follow	VBN
cord-015021-pol2qm74	6459	23	by	by	IN
cord-015021-pol2qm74	6459	24	reinfusion	reinfusion	NN
cord-015021-pol2qm74	6459	25	of	of	IN
cord-015021-pol2qm74	6459	26	shed	shed	JJ
cord-015021-pol2qm74	6459	27	blood	blood	NN
cord-015021-pol2qm74	6459	28	(	(	-LRB-
cord-015021-pol2qm74	6459	29	SB	SB	NNP
cord-015021-pol2qm74	6459	30	)	)	-RRB-
cord-015021-pol2qm74	6459	31	and	and	CC
cord-015021-pol2qm74	6459	32	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6459	33	with	with	IN
cord-015021-pol2qm74	6459	34	two	two	CD
cord-015021-pol2qm74	6459	35	times	time	NNS
cord-015021-pol2qm74	6459	36	of	of	IN
cord-015021-pol2qm74	6459	37	SB	SB	NNP
cord-015021-pol2qm74	6459	38	volume	volume	NN
cord-015021-pol2qm74	6459	39	of	of	IN
cord-015021-pol2qm74	6459	40	Ringer	Ringer	NNP
cord-015021-pol2qm74	6459	41	's	's	POS
cord-015021-pol2qm74	6459	42	lactate	lactate	NN
cord-015021-pol2qm74	6459	43	over	over	IN
cord-015021-pol2qm74	6459	44	50	50	CD
cord-015021-pol2qm74	6459	45	rain	rain	NN
cord-015021-pol2qm74	6459	46	.	.	.
cord-015021-pol2qm74	6460	1	rBPlg	rBPlg	NNP
cord-015021-pol2qm74	6460	2	.	.	.
cord-015021-pol2qm74	6461	1	1	1	CD
cord-015021-pol2qm74	6461	2	was	be	VBD
cord-015021-pol2qm74	6461	3	administered	administer	VBN
cord-015021-pol2qm74	6461	4	at	at	IN
cord-015021-pol2qm74	6461	5	a	a	DT
cord-015021-pol2qm74	6461	6	total	total	JJ
cord-015021-pol2qm74	6461	7	dose	dose	NN
cord-015021-pol2qm74	6461	8	of	of	IN
cord-015021-pol2qm74	6461	9	5	5	CD
cord-015021-pol2qm74	6461	10	mg	mg	NNP
cord-015021-pol2qm74	6461	11	/	/	SYM
cord-015021-pol2qm74	6461	12	kg	kg	NNP
cord-015021-pol2qm74	6461	13	i.v	i.v	NNP
cord-015021-pol2qm74	6461	14	.	.	.
cord-015021-pol2qm74	6462	1	(	(	-LRB-
cord-015021-pol2qm74	6462	2	2.0	2.0	CD
cord-015021-pol2qm74	6462	3	mg	mg	NNP
cord-015021-pol2qm74	6462	4	/	/	SYM
cord-015021-pol2qm74	6462	5	kg	kg	NN
cord-015021-pol2qm74	6462	6	at	at	IN
cord-015021-pol2qm74	6462	7	the16-eginning	the16-eginning	NN
cord-015021-pol2qm74	6462	8	followed	follow	VBN
cord-015021-pol2qm74	6462	9	by	by	IN
cord-015021-pol2qm74	6462	10	two	two	CD
cord-015021-pol2qm74	6462	11	doses	dose	NNS
cord-015021-pol2qm74	6462	12	of	of	IN
cord-015021-pol2qm74	6462	13	1.5	1.5	CD
cord-015021-pol2qm74	6462	14	mg	mg	NNP
cord-015021-pol2qm74	6462	15	/	/	SYM
cord-015021-pol2qm74	6462	16	kg	kg	VBZ
cord-015021-pol2qm74	6462	17	each	each	DT
cord-015021-pol2qm74	6462	18	at	at	IN
cord-015021-pol2qm74	6462	19	end	end	NN
cord-015021-pol2qm74	6462	20	of	of	IN
cord-015021-pol2qm74	6462	21	shock	shock	NN
cord-015021-pol2qm74	6462	22	and	and	CC
cord-015021-pol2qm74	6462	23	the	the	DT
cord-015021-pol2qm74	6462	24	end	end	NN
cord-015021-pol2qm74	6462	25	of	of	IN
cord-015021-pol2qm74	6462	26	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6462	27	)	)	-RRB-
cord-015021-pol2qm74	6462	28	.	.	.
cord-015021-pol2qm74	6463	1	The	the	DT
cord-015021-pol2qm74	6463	2	control	control	NN
cord-015021-pol2qm74	6463	3	group	group	NN
cord-015021-pol2qm74	6463	4	was	be	VBD
cord-015021-pol2qm74	6463	5	treated	treat	VBN
cord-015021-pol2qm74	6463	6	similar	similar	JJ
cord-015021-pol2qm74	6463	7	to	to	IN
cord-015021-pol2qm74	6463	8	the	the	DT
cord-015021-pol2qm74	6463	9	BPI	BPI	NNP
cord-015021-pol2qm74	6463	10	group	group	NN
cord-015021-pol2qm74	6463	11	but	but	CC
cord-015021-pol2qm74	6463	12	received	receive	VBD
cord-015021-pol2qm74	6463	13	thaumatin	thaumatin	NN
cord-015021-pol2qm74	6463	14	as	as	IN
cord-015021-pol2qm74	6463	15	a	a	DT
cord-015021-pol2qm74	6463	16	protein	protein	NN
cord-015021-pol2qm74	6463	17	control	control	NN
cord-015021-pol2qm74	6463	18	preparation	preparation	NN
cord-015021-pol2qm74	6463	19	at	at	IN
cord-015021-pol2qm74	6463	20	the	the	DT
cord-015021-pol2qm74	6463	21	same	same	JJ
cord-015021-pol2qm74	6463	22	dose	dose	NN
cord-015021-pol2qm74	6463	23	as	as	IN
cord-015021-pol2qm74	6463	24	rBPI21	rBPI21	NNP
cord-015021-pol2qm74	6463	25	.	.	.
cord-015021-pol2qm74	6464	1	Results	result	NNS
cord-015021-pol2qm74	6464	2	:	:	:
cord-015021-pol2qm74	6465	1	Imrffe?diately	imrffe?diately	RB
cord-015021-pol2qm74	6465	2	after	after	IN
cord-015021-pol2qm74	6465	3	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6465	4	(	(	-LRB-
cord-015021-pol2qm74	6465	5	230	230	CD
cord-015021-pol2qm74	6465	6	min	min	NN
cord-015021-pol2qm74	6465	7	)	)	-RRB-
cord-015021-pol2qm74	6466	1	the	the	DT
cord-015021-pol2qm74	6466	2	detected	detect	VBN
cord-015021-pol2qm74	6466	3	plasma	plasma	NN
cord-015021-pol2qm74	6466	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6466	5	levels	level	NNS
cord-015021-pol2qm74	6466	6	in	in	IN
cord-015021-pol2qm74	6466	7	the	the	DT
cord-015021-pol2qm74	6466	8	control	control	NN
cord-015021-pol2qm74	6466	9	group	group	NN
cord-015021-pol2qm74	6466	10	(	(	-LRB-
cord-015021-pol2qm74	6466	11	mean	mean	NNP
cord-015021-pol2qm74	6466	12	=	=	SYM
cord-015021-pol2qm74	6466	13	61	61	CD
cord-015021-pol2qm74	6466	14	,	,	,
cord-015021-pol2qm74	6466	15	range	range	NN
cord-015021-pol2qm74	6466	16	=	=	SYM
cord-015021-pol2qm74	6466	17	0	0	CD
cord-015021-pol2qm74	6466	18	-	-	SYM
cord-015021-pol2qm74	6466	19	120	120	CD
cord-015021-pol2qm74	6466	20	pg	pg	NN
cord-015021-pol2qm74	6466	21	/	/	SYM
cord-015021-pol2qm74	6466	22	ml	ml	NN
cord-015021-pol2qm74	6466	23	)	)	-RRB-
cord-015021-pol2qm74	6466	24	were	be	VBD
cord-015021-pol2qm74	6466	25	almost	almost	RB
cord-015021-pol2qm74	6466	26	neutralized	neutralize	VBN
cord-015021-pol2qm74	6466	27	by	by	IN
cord-015021-pol2qm74	6466	28	rBPI21	rBPI21	NNP
cord-015021-pol2qm74	6466	29	treatment	treatment	NN
cord-015021-pol2qm74	6466	30	(	(	-LRB-
cord-015021-pol2qm74	6466	31	mean	mean	VB
cord-015021-pol2qm74	6466	32	=	=	SYM
cord-015021-pol2qm74	6466	33	13	13	CD
cord-015021-pol2qm74	6466	34	,	,	,
cord-015021-pol2qm74	6466	35	range	range	NN
cord-015021-pol2qm74	6466	36	=	=	SYM
cord-015021-pol2qm74	6466	37	0	0	CD
cord-015021-pol2qm74	6466	38	-	-	SYM
cord-015021-pol2qm74	6466	39	53	53	CD
cord-015021-pol2qm74	6466	40	pg	pg	NN
cord-015021-pol2qm74	6466	41	/	/	SYM
cord-015021-pol2qm74	6466	42	ml	ml	NN
cord-015021-pol2qm74	6466	43	)	)	-RRB-
cord-015021-pol2qm74	6466	44	.	.	.
cord-015021-pol2qm74	6467	1	Plasma	plasma	NN
cord-015021-pol2qm74	6467	2	TNF	TNF	NNP
cord-015021-pol2qm74	6467	3	levYIs	levYIs	NNP
cord-015021-pol2qm74	6467	4	were	be	VBD
cord-015021-pol2qm74	6467	5	not	not	RB
cord-015021-pol2qm74	6467	6	significantly	significantly	RB
cord-015021-pol2qm74	6467	7	influenced	influence	VBN
cord-015021-pol2qm74	6467	8	by	by	IN
cord-015021-pol2qm74	6467	9	rBPI	rbpi	CD
cord-015021-pol2qm74	6467	10	treatment	treatment	NN
cord-015021-pol2qm74	6467	11	at	at	IN
cord-015021-pol2qm74	6467	12	the	the	DT
cord-015021-pol2qm74	6467	13	two	two	CD
cord-015021-pol2qm74	6467	14	time	time	NN
cord-015021-pol2qm74	6467	15	points	point	VBZ
cord-015021-pol2qm74	6467	16	230	230	CD
cord-015021-pol2qm74	6467	17	and	and	CC
cord-015021-pol2qm74	6467	18	320	320	CD
cord-015021-pol2qm74	6467	19	min	min	NN
cord-015021-pol2qm74	6467	20	of	of	IN
cord-015021-pol2qm74	6467	21	experiment	experiment	NN
cord-015021-pol2qm74	6467	22	(	(	-LRB-
cord-015021-pol2qm74	6467	23	means	mean	VBZ
cord-015021-pol2qm74	6467	24	:	:	:
cord-015021-pol2qm74	6467	25	65	65	CD
cord-015021-pol2qm74	6467	26	and	and	CC
cord-015021-pol2qm74	6467	27	51	51	CD
cord-015021-pol2qm74	6467	28	in	in	IN
cord-015021-pol2qm74	6467	29	BPI	BPI	NNP
cord-015021-pol2qm74	6467	30	vs	vs	IN
cord-015021-pol2qm74	6467	31	49	49	CD
cord-015021-pol2qm74	6467	32	,	,	,
cord-015021-pol2qm74	6467	33	65	65	CD
cord-015021-pol2qm74	6467	34	pg	pg	NN
cord-015021-pol2qm74	6467	35	/	/	SYM
cord-015021-pol2qm74	6467	36	ml	ml	XX
cord-015021-pol2qm74	6467	37	in	in	IN
cord-015021-pol2qm74	6467	38	the	the	DT
cord-015021-pol2qm74	6467	39	control	control	NN
cord-015021-pol2qm74	6467	40	group	group	NN
cord-015021-pol2qm74	6467	41	)	)	-RRB-
cord-015021-pol2qm74	6467	42	.	.	.
cord-015021-pol2qm74	6468	1	The	the	DT
cord-015021-pol2qm74	6468	2	48-hour	48-hour	JJ
cord-015021-pol2qm74	6468	3	survival	survival	NN
cord-015021-pol2qm74	6468	4	rate	rate	NN
cord-015021-pol2qm74	6468	5	was	be	VBD
cord-015021-pol2qm74	6468	6	improved	improve	VBN
cord-015021-pol2qm74	6468	7	from	from	IN
cord-015021-pol2qm74	6468	8	6/16	6/16	CD
cord-015021-pol2qm74	6468	9	(	(	-LRB-
cord-015021-pol2qm74	6468	10	37.5	37.5	CD
cord-015021-pol2qm74	6468	11	%	%	NN
cord-015021-pol2qm74	6468	12	)	)	-RRB-
cord-015021-pol2qm74	6468	13	in	in	IN
cord-015021-pol2qm74	6468	14	the	the	DT
cord-015021-pol2qm74	6468	15	control	control	NN
cord-015021-pol2qm74	6468	16	to	to	IN
cord-015021-pol2qm74	6468	17	11/16	11/16	CD
cord-015021-pol2qm74	6468	18	(	(	-LRB-
cord-015021-pol2qm74	6468	19	69	69	CD
cord-015021-pol2qm74	6468	20	%	%	NN
cord-015021-pol2qm74	6468	21	)	)	-RRB-
cord-015021-pol2qm74	6468	22	.	.	.
cord-015021-pol2qm74	6469	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	6469	2	:	:	:
cord-015021-pol2qm74	6470	1	These	these	DT
cord-015021-pol2qm74	6470	2	data	datum	NNS
cord-015021-pol2qm74	6470	3	suggest	suggest	VBP
cord-015021-pol2qm74	6470	4	that	that	IN
cord-015021-pol2qm74	6470	5	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	6470	6	shock	shock	NN
cord-015021-pol2qm74	6470	7	may	may	MD
cord-015021-pol2qm74	6470	8	lead	lead	VB
cord-015021-pol2qm74	6470	9	to	to	IN
cord-015021-pol2qm74	6470	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	6470	11	translocation	translocation	NN
cord-015021-pol2qm74	6470	12	and/or	and/or	CC
cord-015021-pol2qm74	6470	13	transient	transient	JJ
cord-015021-pol2qm74	6470	14	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	6470	15	with	with	IN
cord-015021-pol2qm74	6470	16	concomitant	concomitant	JJ
cord-015021-pol2qm74	6470	17	cytokine	cytokine	NN
cord-015021-pol2qm74	6470	18	formation	formation	NN
cord-015021-pol2qm74	6470	19	that	that	WDT
cord-015021-pol2qm74	6470	20	may	may	MD
cord-015021-pol2qm74	6470	21	play	play	VB
cord-015021-pol2qm74	6470	22	an	an	DT
cord-015021-pol2qm74	6470	23	important	important	JJ
cord-015021-pol2qm74	6470	24	role	role	NN
cord-015021-pol2qm74	6470	25	in	in	IN
cord-015021-pol2qm74	6470	26	the	the	DT
cord-015021-pol2qm74	6470	27	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	6470	28	after	after	IN
cord-015021-pol2qm74	6470	29	shock	shock	NN
cord-015021-pol2qm74	6470	30	and	and	CC
cord-015021-pol2qm74	6470	31	trauma	trauma	NN
cord-015021-pol2qm74	6470	32	,	,	,
cord-015021-pol2qm74	6470	33	rBPI21	rBPI21	NNP
cord-015021-pol2qm74	6470	34	might	may	MD
cord-015021-pol2qm74	6470	35	be	be	VB
cord-015021-pol2qm74	6470	36	a	a	DT
cord-015021-pol2qm74	6470	37	useful	useful	JJ
cord-015021-pol2qm74	6470	38	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6470	39	agent	agent	NN
cord-015021-pol2qm74	6470	40	against	against	IN
cord-015021-pol2qm74	6470	41	endogenous	endogenous	JJ
cord-015021-pol2qm74	6470	42	bacterFal	bacterFal	NNS
cord-015021-pol2qm74	6470	43	/	/	SYM
cord-015021-pol2qm74	6470	44	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6470	45	related	relate	VBN
cord-015021-pol2qm74	6470	46	disorders	disorder	NNS
cord-015021-pol2qm74	6470	47	in	in	IN
cord-015021-pol2qm74	6470	48	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	6470	49	shock	shock	NN
cord-015021-pol2qm74	6470	50	.	.	.
cord-015021-pol2qm74	6471	1	Morbidity	morbidity	NN
cord-015021-pol2qm74	6471	2	and	and	CC
cord-015021-pol2qm74	6471	3	mortality	mortality	NN
cord-015021-pol2qm74	6471	4	after	after	IN
cord-015021-pol2qm74	6471	5	hypoxia	hypoxia	NN
cord-015021-pol2qm74	6471	6	of	of	IN
cord-015021-pol2qm74	6471	7	the	the	DT
cord-015021-pol2qm74	6471	8	vital	vital	JJ
cord-015021-pol2qm74	6471	9	organs	organ	NNS
cord-015021-pol2qm74	6471	10	had	have	VBD
cord-015021-pol2qm74	6471	11	been	be	VBN
cord-015021-pol2qm74	6471	12	correlated	correlate	VBN
cord-015021-pol2qm74	6471	13	to	to	IN
cord-015021-pol2qm74	6471	14	the	the	DT
cord-015021-pol2qm74	6471	15	production	production	NN
cord-015021-pol2qm74	6471	16	of	of	IN
cord-015021-pol2qm74	6471	17	oxygen	oxygen	NN
cord-015021-pol2qm74	6471	18	radicle	radicle	NN
cord-015021-pol2qm74	6471	19	which	which	WDT
cord-015021-pol2qm74	6471	20	is	be	VBZ
cord-015021-pol2qm74	6471	21	mediated	mediate	VBN
cord-015021-pol2qm74	6471	22	by	by	IN
cord-015021-pol2qm74	6471	23	xanthine	xanthine	NN
cord-015021-pol2qm74	6471	24	oxidase	oxidase	NN
cord-015021-pol2qm74	6471	25	activity	activity	NN
cord-015021-pol2qm74	6471	26	,	,	,
cord-015021-pol2qm74	6471	27	In	in	IN
cord-015021-pol2qm74	6471	28	this	this	DT
cord-015021-pol2qm74	6471	29	study	study	NN
cord-015021-pol2qm74	6471	30	we	-PRON-	PRP
cord-015021-pol2qm74	6471	31	have	have	VBP
cord-015021-pol2qm74	6471	32	evaluated	evaluate	VBN
cord-015021-pol2qm74	6471	33	the	the	DT
cord-015021-pol2qm74	6471	34	survival	survival	NN
cord-015021-pol2qm74	6471	35	rate	rate	NN
cord-015021-pol2qm74	6471	36	after	after	IN
cord-015021-pol2qm74	6471	37	allopurinol	allopurinol	NN
cord-015021-pol2qm74	6471	38	.	.	.
cord-015021-pol2qm74	6472	1	42	42	CD
cord-015021-pol2qm74	6472	2	rabbits	rabbit	NNS
cord-015021-pol2qm74	6472	3	weighed	weigh	VBD
cord-015021-pol2qm74	6472	4	900	900	CD
cord-015021-pol2qm74	6472	5	+	+	SYM
cord-015021-pol2qm74	6472	6	200	200	CD
cord-015021-pol2qm74	6472	7	grams	gram	NNS
cord-015021-pol2qm74	6472	8	divided	divide	VBN
cord-015021-pol2qm74	6472	9	into	into	IN
cord-015021-pol2qm74	6472	10	two	two	CD
cord-015021-pol2qm74	6472	11	groups	group	NNS
cord-015021-pol2qm74	6472	12	.	.	.
cord-015021-pol2qm74	6473	1	Group	group	NN
cord-015021-pol2qm74	6474	1	I	-PRON-	PRP
cord-015021-pol2qm74	6474	2	included	include	VBD
cord-015021-pol2qm74	6474	3	22	22	CD
cord-015021-pol2qm74	6474	4	Tabbits	tabbit	NNS
cord-015021-pol2qm74	6474	5	were	be	VBD
cord-015021-pol2qm74	6474	6	treated	treat	VBN
cord-015021-pol2qm74	6474	7	with	with	IN
cord-015021-pol2qm74	6474	8	allopurinol	allopurinol	NN
cord-015021-pol2qm74	6474	9	80	80	CD
cord-015021-pol2qm74	6474	10	mg	mg	NNP
cord-015021-pol2qm74	6474	11	/	/	SYM
cord-015021-pol2qm74	6474	12	kg	kg	NN
cord-015021-pol2qm74	6474	13	for	for	IN
cord-015021-pol2qm74	6474	14	seven	seven	CD
cord-015021-pol2qm74	6474	15	days	day	NNS
cord-015021-pol2qm74	6474	16	before	before	IN
cord-015021-pol2qm74	6474	17	induction	induction	NN
cord-015021-pol2qm74	6474	18	of	of	IN
cord-015021-pol2qm74	6474	19	haemorrhage	haemorrhage	NN
cord-015021-pol2qm74	6474	20	.	.	.
cord-015021-pol2qm74	6475	1	Group	Group	NNP
cord-015021-pol2qm74	6475	2	II	II	NNP
cord-015021-pol2qm74	6475	3	as	as	IN
cord-015021-pol2qm74	6475	4	a	a	DT
cord-015021-pol2qm74	6475	5	control	control	NN
cord-015021-pol2qm74	6475	6	included	include	VBD
cord-015021-pol2qm74	6475	7	20	20	CD
cord-015021-pol2qm74	6475	8	rabbits	rabbit	NNS
cord-015021-pol2qm74	6475	9	.	.	.
cord-015021-pol2qm74	6476	1	All	all	DT
cord-015021-pol2qm74	6476	2	rabbits	rabbit	NNS
cord-015021-pol2qm74	6476	3	were	be	VBD
cord-015021-pol2qm74	6476	4	subjected	subject	VBN
cord-015021-pol2qm74	6476	5	to	to	IN
cord-015021-pol2qm74	6476	6	25	25	CD
cord-015021-pol2qm74	6476	7	%	%	NN
cord-015021-pol2qm74	6476	8	arterial	arterial	JJ
cord-015021-pol2qm74	6476	9	blood	blood	NN
cord-015021-pol2qm74	6476	10	loss	loss	NN
cord-015021-pol2qm74	6476	11	through	through	IN
cord-015021-pol2qm74	6476	12	the	the	DT
cord-015021-pol2qm74	6476	13	central	central	JJ
cord-015021-pol2qm74	6476	14	ear	ear	NN
cord-015021-pol2qm74	6476	15	artery	artery	NN
cord-015021-pol2qm74	6476	16	for	for	IN
cord-015021-pol2qm74	6476	17	one	one	CD
cord-015021-pol2qm74	6476	18	hour	hour	NN
cord-015021-pol2qm74	6477	1	then	then	RB
cord-015021-pol2qm74	6477	2	resusciatation	resusciatation	NN
cord-015021-pol2qm74	6477	3	was	be	VBD
cord-015021-pol2qm74	6477	4	done	do	VBN
cord-015021-pol2qm74	6477	5	by	by	IN
cord-015021-pol2qm74	6477	6	the	the	DT
cord-015021-pol2qm74	6477	7	heparinized	heparinize	VBN
cord-015021-pol2qm74	6477	8	withdrawn	withdraw	VBN
cord-015021-pol2qm74	6477	9	blood	blood	NN
cord-015021-pol2qm74	6477	10	through	through	IN
cord-015021-pol2qm74	6477	11	a	a	DT
cord-015021-pol2qm74	6477	12	marginal	marginal	JJ
cord-015021-pol2qm74	6477	13	ear	ear	NN
cord-015021-pol2qm74	6477	14	vein	vein	NN
cord-015021-pol2qm74	6477	15	.	.	.
cord-015021-pol2qm74	6478	1	During	during	IN
cord-015021-pol2qm74	6478	2	the	the	DT
cord-015021-pol2qm74	6478	3	experiment	experiment	NN
cord-015021-pol2qm74	6478	4	blood	blood	NN
cord-015021-pol2qm74	6478	5	pressure	pressure	NN
cord-015021-pol2qm74	6478	6	and	and	CC
cord-015021-pol2qm74	6478	7	heart	heart	NN
cord-015021-pol2qm74	6478	8	rate	rate	NN
cord-015021-pol2qm74	6478	9	were	be	VBD
cord-015021-pol2qm74	6478	10	monitored	monitor	VBN
cord-015021-pol2qm74	6478	11	through	through	IN
cord-015021-pol2qm74	6478	12	the	the	DT
cord-015021-pol2qm74	6478	13	central	central	JJ
cord-015021-pol2qm74	6478	14	ear	ear	NN
cord-015021-pol2qm74	6478	15	artery	artery	NN
cord-015021-pol2qm74	6478	16	.	.	.
cord-015021-pol2qm74	6479	1	ALso	also	RB
cord-015021-pol2qm74	6479	2	uric	uric	NN
cord-015021-pol2qm74	6479	3	acid	acid	NN
cord-015021-pol2qm74	6479	4	,	,	,
cord-015021-pol2qm74	6479	5	lactic	lactic	JJ
cord-015021-pol2qm74	6479	6	acid	acid	NN
cord-015021-pol2qm74	6479	7	,	,	,
cord-015021-pol2qm74	6479	8	glutathione	glutathione	NN
cord-015021-pol2qm74	6479	9	activity	activity	NN
cord-015021-pol2qm74	6479	10	were	be	VBD
cord-015021-pol2qm74	6479	11	estimated	estimate	VBN
cord-015021-pol2qm74	6479	12	.	.	.
cord-015021-pol2qm74	6480	1	Animal	animal	NN
cord-015021-pol2qm74	6480	2	survival	survival	NN
cord-015021-pol2qm74	6480	3	was	be	VBD
cord-015021-pol2qm74	6480	4	followed	follow	VBN
cord-015021-pol2qm74	6480	5	for	for	IN
cord-015021-pol2qm74	6480	6	10	10	CD
cord-015021-pol2qm74	6480	7	days	day	NNS
cord-015021-pol2qm74	6480	8	.	.	.
cord-015021-pol2qm74	6481	1	Postmortem	postmortem	JJ
cord-015021-pol2qm74	6481	2	vital	vital	JJ
cord-015021-pol2qm74	6481	3	organ	organ	NN
cord-015021-pol2qm74	6481	4	histochemistry	histochemistry	NN
cord-015021-pol2qm74	6481	5	and	and	CC
cord-015021-pol2qm74	6481	6	histopathology	histopathology	NN
cord-015021-pol2qm74	6481	7	examinations	examination	NNS
cord-015021-pol2qm74	6481	8	were	be	VBD
cord-015021-pol2qm74	6481	9	done	do	VBN
cord-015021-pol2qm74	6481	10	.	.	.
cord-015021-pol2qm74	6482	1	In	in	IN
cord-015021-pol2qm74	6482	2	group	group	NN
cord-015021-pol2qm74	6482	3	I	-PRON-	PRP
cord-015021-pol2qm74	6482	4	the	the	DT
cord-015021-pol2qm74	6482	5	survival	survival	NN
cord-015021-pol2qm74	6482	6	after	after	IN
cord-015021-pol2qm74	6482	7	three	three	CD
cord-015021-pol2qm74	6482	8	days	day	NNS
cord-015021-pol2qm74	6482	9	was	be	VBD
cord-015021-pol2qm74	6482	10	10	10	CD
cord-015021-pol2qm74	6482	11	out	out	IN
cord-015021-pol2qm74	6482	12	of	of	IN
cord-015021-pol2qm74	6482	13	22	22	CD
cord-015021-pol2qm74	6482	14	while	while	NN
cord-015021-pol2qm74	6482	15	in	in	IN
cord-015021-pol2qm74	6482	16	group	group	NN
cord-015021-pol2qm74	6482	17	II	II	NNP
cord-015021-pol2qm74	6482	18	it	-PRON-	PRP
cord-015021-pol2qm74	6482	19	was	be	VBD
cord-015021-pol2qm74	6482	20	two	two	CD
cord-015021-pol2qm74	6482	21	out	out	IN
cord-015021-pol2qm74	6482	22	of	of	IN
cord-015021-pol2qm74	6482	23	20	20	CD
cord-015021-pol2qm74	6482	24	.	.	.
cord-015021-pol2qm74	6483	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	6483	2	conc|usion	conc|usion	NN
cord-015021-pol2qm74	6483	3	,	,	,
cord-015021-pol2qm74	6483	4	allopurinol	allopurinol	NN
cord-015021-pol2qm74	6483	5	had	have	VBD
cord-015021-pol2qm74	6483	6	increased	increase	VBN
cord-015021-pol2qm74	6483	7	the	the	DT
cord-015021-pol2qm74	6483	8	survival	survival	NN
cord-015021-pol2qm74	6483	9	in	in	IN
cord-015021-pol2qm74	6483	10	aiiopurinol	aiiopurinol	NN
cord-015021-pol2qm74	6483	11	pretreated	pretreate	VBN
cord-015021-pol2qm74	6483	12	rabbits	rabbit	NNS
cord-015021-pol2qm74	6483	13	which	which	WDT
cord-015021-pol2qm74	6483	14	may	may	MD
cord-015021-pol2qm74	6483	15	indicate	indicate	VB
cord-015021-pol2qm74	6483	16	the	the	DT
cord-015021-pol2qm74	6483	17	value	value	NN
cord-015021-pol2qm74	6483	18	of	of	IN
cord-015021-pol2qm74	6483	19	allopurinol	allopurinol	NN
cord-015021-pol2qm74	6483	20	premedication	premedication	NN
cord-015021-pol2qm74	6483	21	for	for	IN
cord-015021-pol2qm74	6483	22	patient	patient	NN
cord-015021-pol2qm74	6483	23	prepared	prepare	VBN
cord-015021-pol2qm74	6483	24	for	for	IN
cord-015021-pol2qm74	6483	25	elective	elective	JJ
cord-015021-pol2qm74	6483	26	bloody	bloody	JJ
cord-015021-pol2qm74	6483	27	surgical	surgical	JJ
cord-015021-pol2qm74	6483	28	intervention	intervention	NN
cord-015021-pol2qm74	6483	29	.	.	.
cord-015021-pol2qm74	6484	1	H2	H2	NNP
cord-015021-pol2qm74	6484	2	receptor	receptor	NN
cord-015021-pol2qm74	6484	3	antagonists	antagonist	NNS
cord-015021-pol2qm74	6484	4	are	be	VBP
cord-015021-pol2qm74	6484	5	commonly	commonly	RB
cord-015021-pol2qm74	6484	6	used	use	VBN
cord-015021-pol2qm74	6484	7	for	for	IN
cord-015021-pol2qm74	6484	8	stress	stress	NN
cord-015021-pol2qm74	6484	9	ulcer	ulcer	NN
cord-015021-pol2qm74	6484	10	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	6484	11	,	,	,
cord-015021-pol2qm74	6484	12	but	but	CC
cord-015021-pol2qm74	6484	13	their	-PRON-	PRP$
cord-015021-pol2qm74	6484	14	actions	action	NNS
cord-015021-pol2qm74	6484	15	on	on	IN
cord-015021-pol2qm74	6484	16	the	the	DT
cord-015021-pol2qm74	6484	17	septic	septic	JJ
cord-015021-pol2qm74	6484	18	response	response	NN
cord-015021-pol2qm74	6484	19	are	be	VBP
cord-015021-pol2qm74	6484	20	largely	largely	RB
cord-015021-pol2qm74	6484	21	unknown	unknown	JJ
cord-015021-pol2qm74	6484	22	,	,	,
cord-015021-pol2qm74	6484	23	In	in	IN
cord-015021-pol2qm74	6484	24	an	an	DT
cord-015021-pol2qm74	6484	25	experimental	experimental	JJ
cord-015021-pol2qm74	6484	26	model	model	NN
cord-015021-pol2qm74	6484	27	,	,	,
cord-015021-pol2qm74	6484	28	26	26	CD
cord-015021-pol2qm74	6484	29	pigs	pig	NNS
cord-015021-pol2qm74	6484	30	were	be	VBD
cord-015021-pol2qm74	6484	31	first	first	RB
cord-015021-pol2qm74	6484	32	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	6484	33	,	,	,
cord-015021-pol2qm74	6484	34	then	then	RB
cord-015021-pol2qm74	6484	35	injured	injure	VBN
cord-015021-pol2qm74	6484	36	with	with	IN
cord-015021-pol2qm74	6484	37	100	100	CD
cord-015021-pol2qm74	6484	38	joules	joule	NNS
cord-015021-pol2qm74	6484	39	of	of	IN
cord-015021-pol2qm74	6484	40	energy	energy	NN
cord-015021-pol2qm74	6484	41	to	to	IN
cord-015021-pol2qm74	6484	42	the	the	DT
cord-015021-pol2qm74	6484	43	posterior	posterior	JJ
cord-015021-pol2qm74	6484	44	thigh	thigh	NN
cord-015021-pol2qm74	6484	45	,	,	,
cord-015021-pol2qm74	6484	46	then	then	RB
cord-015021-pol2qm74	6484	47	hemorrhaged	hemorrhage	VBD
cord-015021-pol2qm74	6484	48	30	30	CD
cord-015021-pol2qm74	6484	49	-	-	SYM
cord-015021-pol2qm74	6484	50	40	40	CD
cord-015021-pol2qm74	6484	51	%	%	NN
cord-015021-pol2qm74	6484	52	of	of	IN
cord-015021-pol2qm74	6484	53	their	-PRON-	PRP$
cord-015021-pol2qm74	6484	54	blood	blood	NN
cord-015021-pol2qm74	6484	55	volume	volume	NN
cord-015021-pol2qm74	6484	56	.	.	.
cord-015021-pol2qm74	6485	1	After	after	IN
cord-015021-pol2qm74	6485	2	I	-PRON-	PRP
cord-015021-pol2qm74	6485	3	hr	hr	NN
cord-015021-pol2qm74	6485	4	of	of	IN
cord-015021-pol2qm74	6485	5	shock	shock	NN
cord-015021-pol2qm74	6485	6	,	,	,
cord-015021-pol2qm74	6485	7	all	all	PDT
cord-015021-pol2qm74	6485	8	the	the	DT
cord-015021-pol2qm74	6485	9	shed	shed	JJ
cord-015021-pol2qm74	6485	10	blood	blood	NN
cord-015021-pol2qm74	6485	11	plus	plus	CC
cord-015021-pol2qm74	6485	12	2x	2x	NFP
cord-015021-pol2qm74	6485	13	the	the	DT
cord-015021-pol2qm74	6485	14	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6485	15	volume	volume	NN
cord-015021-pol2qm74	6485	16	as	as	IN
cord-015021-pol2qm74	6485	17	lactated	lactate	VBN
cord-015021-pol2qm74	6485	18	ringers	ringer	NNS
cord-015021-pol2qm74	6485	19	was	be	VBD
cord-015021-pol2qm74	6485	20	infused	infuse	VBN
cord-015021-pol2qm74	6485	21	.	.	.
cord-015021-pol2qm74	6486	1	Following	follow	VBG
cord-015021-pol2qm74	6486	2	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6486	3	,	,	,
cord-015021-pol2qm74	6486	4	ranitidine	ranitidine	NN
cord-015021-pol2qm74	6486	5	(	(	-LRB-
cord-015021-pol2qm74	6486	6	1.5	1.5	CD
cord-015021-pol2qm74	6486	7	mg	mg	NNP
cord-015021-pol2qm74	6486	8	/	/	SYM
cord-015021-pol2qm74	6486	9	kg	kg	NNP
cord-015021-pol2qm74	6486	10	iv	iv	CD
cord-015021-pol2qm74	6486	11	twice	twice	RB
cord-015021-pol2qm74	6486	12	daily	daily	JJ
cord-015021-pol2qm74	6486	13	)	)	-RRB-
cord-015021-pol2qm74	6486	14	or	or	CC
cord-015021-pol2qm74	6486	15	saline	saline	NN
cord-015021-pol2qm74	6486	16	placebo	placebo	NN
cord-015021-pol2qm74	6486	17	was	be	VBD
cord-015021-pol2qm74	6486	18	begun	begin	VBN
cord-015021-pol2qm74	6486	19	.	.	.
cord-015021-pol2qm74	6487	1	The	the	DT
cord-015021-pol2qm74	6487	2	treatment	treatment	NN
cord-015021-pol2qm74	6487	3	group	group	NN
cord-015021-pol2qm74	6487	4	was	be	VBD
cord-015021-pol2qm74	6487	5	randomly	randomly	RB
cord-015021-pol2qm74	6487	6	assigned	assign	VBN
cord-015021-pol2qm74	6487	7	in	in	IN
cord-015021-pol2qm74	6487	8	a	a	DT
cord-015021-pol2qm74	6487	9	blinded	blinded	JJ
cord-015021-pol2qm74	6487	10	fashion	fashion	NN
cord-015021-pol2qm74	6487	11	.	.	.
cord-015021-pol2qm74	6488	1	After	after	IN
cord-015021-pol2qm74	6488	2	72	72	CD
cord-015021-pol2qm74	6488	3	hrs	hrs	NN
cord-015021-pol2qm74	6488	4	,	,	,
cord-015021-pol2qm74	6488	5	a	a	DT
cord-015021-pol2qm74	6488	6	septic	septic	JJ
cord-015021-pol2qm74	6488	7	challenge	challenge	NN
cord-015021-pol2qm74	6488	8	was	be	VBD
cord-015021-pol2qm74	6488	9	administered	administer	VBN
cord-015021-pol2qm74	6488	10	(	(	-LRB-
cord-015021-pol2qm74	6488	11	15	15	CD
cord-015021-pol2qm74	6488	12	Bg	Bg	NNP
cord-015021-pol2qm74	6488	13	/	/	SYM
cord-015021-pol2qm74	6488	14	kg	kg	NNP
cord-015021-pol2qm74	6488	15	of	of	IN
cord-015021-pol2qm74	6488	16	E.	E.	NNP
cord-015021-pol2qm74	6488	17	coil	coil	NN
cord-015021-pol2qm74	6488	18	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6488	19	(	(	-LRB-
cord-015021-pol2qm74	6488	20	LPS	LPS	NNP
cord-015021-pol2qm74	6488	21	)	)	-RRB-
cord-015021-pol2qm74	6488	22	)	)	-RRB-
cord-015021-pol2qm74	6488	23	.	.	.
cord-015021-pol2qm74	6489	1	Serial	serial	JJ
cord-015021-pol2qm74	6489	2	gastroscopy	gastroscopy	NN
cord-015021-pol2qm74	6489	3	,	,	,
cord-015021-pol2qm74	6489	4	gastric	gastric	JJ
cord-015021-pol2qm74	6489	5	pH	ph	NN
cord-015021-pol2qm74	6489	6	,	,	,
cord-015021-pol2qm74	6489	7	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	6489	8	,	,	,
cord-015021-pol2qm74	6489	9	ABG	ABG	NNP
cord-015021-pol2qm74	6489	10	's	's	POS
cord-015021-pol2qm74	6489	11	,	,	,
cord-015021-pol2qm74	6489	12	physiologic	physiologic	JJ
cord-015021-pol2qm74	6489	13	dead	dead	JJ
cord-015021-pol2qm74	6489	14	space	space	NN
cord-015021-pol2qm74	6489	15	ventilation	ventilation	NN
cord-015021-pol2qm74	6489	16	,	,	,
cord-015021-pol2qm74	6489	17	leukocyte	leukocyte	NN
cord-015021-pol2qm74	6489	18	counts	count	VBZ
cord-015021-pol2qm74	6489	19	,	,	,
cord-015021-pol2qm74	6489	20	and	and	CC
cord-015021-pol2qm74	6489	21	tumor	tumor	NN
cord-015021-pol2qm74	6489	22	necrosis	necrosis	NN
cord-015021-pol2qm74	6489	23	factor	factor	NN
cord-015021-pol2qm74	6489	24	(	(	-LRB-
cord-015021-pol2qm74	6489	25	TNF	TNF	NNP
cord-015021-pol2qm74	6489	26	)	)	-RRB-
cord-015021-pol2qm74	6489	27	levels	level	NNS
cord-015021-pol2qm74	6489	28	were	be	VBD
cord-015021-pol2qm74	6489	29	recorded	record	VBN
cord-015021-pol2qm74	6489	30	for	for	IN
cord-015021-pol2qm74	6489	31	180	180	CD
cord-015021-pol2qm74	6489	32	min	min	NN
cord-015021-pol2qm74	6489	33	.	.	.
cord-015021-pol2qm74	6490	1	Baseline	baseline	JJ
cord-015021-pol2qm74	6490	2	values	value	NNS
cord-015021-pol2qm74	6490	3	and	and	CC
cord-015021-pol2qm74	6490	4	units	unit	NNS
cord-015021-pol2qm74	6490	5	were	be	VBD
cord-015021-pol2qm74	6490	6	cardiac	cardiac	JJ
cord-015021-pol2qm74	6490	7	index	index	NN
cord-015021-pol2qm74	6490	8	102	102	CD
cord-015021-pol2qm74	6490	9	_	_	NN
cord-015021-pol2qm74	6491	1	+	+	CC
cord-015021-pol2qm74	6492	1	9	9	CD
cord-015021-pol2qm74	6492	2	ml	ml	NN
cord-015021-pol2qm74	6492	3	/	/	SYM
cord-015021-pol2qm74	6492	4	min	min	NN
cord-015021-pol2qm74	6492	5	/	/	SYM
cord-015021-pol2qm74	6492	6	kg	kg	NNP
cord-015021-pol2qm74	6492	7	(	(	-LRB-
cord-015021-pol2qm74	6492	8	CI	CI	NNP
cord-015021-pol2qm74	6492	9	)	)	-RRB-
cord-015021-pol2qm74	6492	10	,	,	,
cord-015021-pol2qm74	6492	11	arterial	arterial	JJ
cord-015021-pol2qm74	6492	12	PO2	PO2	NNP
cord-015021-pol2qm74	6492	13	228	228	CD
cord-015021-pol2qm74	6492	14	+	+	SYM
cord-015021-pol2qm74	6492	15	11	11	CD
cord-015021-pol2qm74	6492	16	mmHg(PaO2	mmHg(PaO2	NNP
cord-015021-pol2qm74	6492	17	)	)	-RRB-
cord-015021-pol2qm74	6492	18	,	,	,
cord-015021-pol2qm74	6492	19	base	base	NN
cord-015021-pol2qm74	6492	20	excess	excess	JJ
cord-015021-pol2qm74	6492	21	6.5	6.5	CD
cord-015021-pol2qm74	6492	22	-+	-+	SYM
cord-015021-pol2qm74	6492	23	1	1	CD
cord-015021-pol2qm74	6492	24	meq	meq	NN
cord-015021-pol2qm74	6492	25	(	(	-LRB-
cord-015021-pol2qm74	6492	26	BE	BE	NNP
cord-015021-pol2qm74	6492	27	)	)	-RRB-
cord-015021-pol2qm74	6492	28	,	,	,
cord-015021-pol2qm74	6492	29	physiologic	physiologic	JJ
cord-015021-pol2qm74	6492	30	dead	dead	JJ
cord-015021-pol2qm74	6492	31	space	space	NN
cord-015021-pol2qm74	6492	32	fraction	fraction	NN
cord-015021-pol2qm74	6492	33	23	23	CD
cord-015021-pol2qm74	6493	1	+	+	CC
cord-015021-pol2qm74	6493	2	_	_	NN
cord-015021-pol2qm74	6493	3	4	4	CD
cord-015021-pol2qm74	6493	4	%	%	NN
cord-015021-pol2qm74	6493	5	(	(	-LRB-
cord-015021-pol2qm74	6493	6	PDS	PDS	NNP
cord-015021-pol2qm74	6493	7	)	)	-RRB-
cord-015021-pol2qm74	6493	8	,	,	,
cord-015021-pol2qm74	6493	9	and	and	CC
cord-015021-pol2qm74	6493	10	TNF	TNF	NNP
cord-015021-pol2qm74	6493	11	0.4	0.4	CD
cord-015021-pol2qm74	6493	12	+	+	SYM
cord-015021-pol2qm74	6493	13	0.1	0.1	CD
cord-015021-pol2qm74	6493	14	units	unit	NNS
cord-015021-pol2qm74	6493	15	/	/	SYM
cord-015021-pol2qm74	6493	16	ml	ml	NN
cord-015021-pol2qm74	6493	17	.	.	.
cord-015021-pol2qm74	6494	1	Baseline	baseline	JJ
cord-015021-pol2qm74	6494	2	gastric	gastric	JJ
cord-015021-pol2qm74	6494	3	pH	ph	NN
cord-015021-pol2qm74	6494	4	was	be	VBD
cord-015021-pol2qm74	6494	5	3.9	3.9	CD
cord-015021-pol2qm74	6494	6	-+	-+	.
cord-015021-pol2qm74	6494	7	0.4	0.4	CD
cord-015021-pol2qm74	6494	8	and	and	CC
cord-015021-pol2qm74	6495	1	4.8	4.8	CD
cord-015021-pol2qm74	6495	2	_	_	NN
cord-015021-pol2qm74	6495	3	+	+	SYM
cord-015021-pol2qm74	6495	4	0.5	0.5	CD
cord-015021-pol2qm74	6495	5	in	in	IN
cord-015021-pol2qm74	6495	6	the	the	DT
cord-015021-pol2qm74	6495	7	placebo	placebo	NN
cord-015021-pol2qm74	6495	8	and	and	CC
cord-015021-pol2qm74	6495	9	ranitidine	ranitidine	NN
cord-015021-pol2qm74	6495	10	groups	group	NNS
cord-015021-pol2qm74	6495	11	,	,	,
cord-015021-pol2qm74	6495	12	respectively	respectively	RB
cord-015021-pol2qm74	6495	13	.	.	.
cord-015021-pol2qm74	6496	1	The	the	DT
cord-015021-pol2qm74	6496	2	gastritis	gastritis	NN
cord-015021-pol2qm74	6496	3	following	follow	VBG
cord-015021-pol2qm74	6496	4	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6496	5	was	be	VBD
cord-015021-pol2qm74	6496	6	marginally	marginally	RB
cord-015021-pol2qm74	6496	7	attenuated	attenuated	JJ
cord-015021-pol2qm74	6496	8	in	in	IN
cord-015021-pol2qm74	6496	9	the	the	DT
cord-015021-pol2qm74	6496	10	ranitidine	ranitidine	NN
cord-015021-pol2qm74	6496	11	group	group	NN
cord-015021-pol2qm74	6496	12	.	.	.
cord-015021-pol2qm74	6497	1	Following	follow	VBG
cord-015021-pol2qm74	6497	2	LPS	LPS	NNP
cord-015021-pol2qm74	6497	3	infusion	infusion	NN
cord-015021-pol2qm74	6497	4	the	the	DT
cord-015021-pol2qm74	6497	5	following	follow	VBG
cord-015021-pol2qm74	6497	6	were	be	VBD
cord-015021-pol2qm74	6497	7	obtained	obtain	VBN
cord-015021-pol2qm74	6497	8	:	:	:
cord-015021-pol2qm74	6497	9	CI	CI	NNP
cord-015021-pol2qm74	6497	10	PaO2	PaO2	NNS
cord-015021-pol2qm74	6498	1	*	*	NFP
cord-015021-pol2qm74	6498	2	BE	be	VB
cord-015021-pol2qm74	6498	3	*	*	NFP
cord-015021-pol2qm74	6499	1	Gastric	gastric	JJ
cord-015021-pol2qm74	6500	1	*	*	NFP
cord-015021-pol2qm74	6500	2	PDS	PDS	NNP
cord-015021-pol2qm74	6501	1	*	*	NFP
cord-015021-pol2qm74	6502	1	Peak	Peak	NNP
cord-015021-pol2qm74	6502	2	*	*	NFP
cord-015021-pol2qm74	6502	3	120	120	CD
cord-015021-pol2qm74	6502	4	rain	rain	VBP
cord-015021-pol2qm74	6502	5	60	60	CD
cord-015021-pol2qm74	6502	6	rain	rain	NN
cord-015021-pol2qm74	6502	7	120	120	CD
cord-015021-pol2qm74	6502	8	rain	rain	NN
cord-015021-pol2qm74	6503	1	pH	pH	NNP
cord-015021-pol2qm74	6504	1	120	120	CD
cord-015021-pol2qm74	6504	2	min	min	NNP
cord-015021-pol2qm74	6504	3	TNF	TNF	NNP
cord-015021-pol2qm74	6504	4	Ranitidine	Ranitidine	NNP
cord-015021-pol2qm74	6504	5	167_+17	167_+17	NNP
cord-015021-pol2qm74	6504	6	118_+15	118_+15	CD
cord-015021-pol2qm74	6504	7	-4.4±1	-4.4±1	NNP
cord-015021-pol2qm74	6504	8	.	.	.
cord-015021-pol2qm74	6505	1	Bum	bum	JJ
cord-015021-pol2qm74	6505	2	injury	injury	NN
cord-015021-pol2qm74	6505	3	results	result	NNS
cord-015021-pol2qm74	6505	4	in	in	IN
cord-015021-pol2qm74	6505	5	hypermetabolism	hypermetabolism	NN
cord-015021-pol2qm74	6505	6	,	,	,
cord-015021-pol2qm74	6505	7	fever	fever	NN
cord-015021-pol2qm74	6505	8	and	and	CC
cord-015021-pol2qm74	6505	9	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6505	10	wasting	wasting	NN
cord-015021-pol2qm74	6505	11	.	.	.
cord-015021-pol2qm74	6506	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	6506	2	(	(	-LRB-
cord-015021-pol2qm74	6506	3	LPS	LPS	NNP
cord-015021-pol2qm74	6506	4	)	)	-RRB-
cord-015021-pol2qm74	6506	5	has	have	VBZ
cord-015021-pol2qm74	6506	6	been	be	VBN
cord-015021-pol2qm74	6506	7	proposed	propose	VBN
cord-015021-pol2qm74	6506	8	to	to	TO
cord-015021-pol2qm74	6506	9	mediate	mediate	VB
cord-015021-pol2qm74	6506	10	these	these	DT
cord-015021-pol2qm74	6506	11	effects	effect	NNS
cord-015021-pol2qm74	6506	12	,	,	,
cord-015021-pol2qm74	6506	13	either	either	CC
cord-015021-pol2qm74	6506	14	directly	directly	RB
cord-015021-pol2qm74	6506	15	or	or	CC
cord-015021-pol2qm74	6506	16	via	via	IN
cord-015021-pol2qm74	6506	17	activation	activation	NN
cord-015021-pol2qm74	6506	18	of	of	IN
cord-015021-pol2qm74	6506	19	macrophages	macrophage	NNS
cord-015021-pol2qm74	6506	20	to	to	TO
cord-015021-pol2qm74	6506	21	produce	produce	VB
cord-015021-pol2qm74	6506	22	cytokines	cytokine	NNS
cord-015021-pol2qm74	6506	23	such	such	JJ
cord-015021-pol2qm74	6506	24	as	as	IN
cord-015021-pol2qm74	6506	25	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	6506	26	(	(	-LRB-
cord-015021-pol2qm74	6506	27	II-6	II-6	NNP
cord-015021-pol2qm74	6506	28	)	)	-RRB-
cord-015021-pol2qm74	6506	29	.	.	.
cord-015021-pol2qm74	6507	1	This	this	DT
cord-015021-pol2qm74	6507	2	study	study	NN
cord-015021-pol2qm74	6507	3	was	be	VBD
cord-015021-pol2qm74	6507	4	designed	design	VBN
cord-015021-pol2qm74	6507	5	to	to	TO
cord-015021-pol2qm74	6507	6	clarify	clarify	VB
cord-015021-pol2qm74	6507	7	the	the	DT
cord-015021-pol2qm74	6507	8	role	role	NN
cord-015021-pol2qm74	6507	9	of	of	IN
cord-015021-pol2qm74	6507	10	LPS	LPS	NNP
cord-015021-pol2qm74	6507	11	and	and	CC
cord-015021-pol2qm74	6507	12	11	11	CD
cord-015021-pol2qm74	6507	13	-	-	SYM
cord-015021-pol2qm74	6507	14	6	6	CD
cord-015021-pol2qm74	6507	15	in	in	IN
cord-015021-pol2qm74	6507	16	the	the	DT
cord-015021-pol2qm74	6507	17	metabolic	metabolic	JJ
cord-015021-pol2qm74	6507	18	response	response	NN
cord-015021-pol2qm74	6507	19	to	to	TO
cord-015021-pol2qm74	6507	20	bum	bum	VB
cord-015021-pol2qm74	6507	21	injury	injury	NN
cord-015021-pol2qm74	6507	22	.	.	.
cord-015021-pol2qm74	6508	1	Twenty	twenty	CD
cord-015021-pol2qm74	6508	2	-	-	HYPH
cord-015021-pol2qm74	6508	3	five	five	CD
cord-015021-pol2qm74	6508	4	burn	burn	NN
cord-015021-pol2qm74	6508	5	patients	patient	NNS
cord-015021-pol2qm74	6508	6	(	(	-LRB-
cord-015021-pol2qm74	6508	7	49	49	CD
cord-015021-pol2qm74	6508	8	-+	-+	SYM
cord-015021-pol2qm74	6508	9	17	17	CD
cord-015021-pol2qm74	6508	10	%	%	NN
cord-015021-pol2qm74	6508	11	;	;	:
cord-015021-pol2qm74	6508	12	16	16	CD
cord-015021-pol2qm74	6508	13	+	+	SYM
cord-015021-pol2qm74	6508	14	15	15	CD
cord-015021-pol2qm74	6508	15	%	%	NN
cord-015021-pol2qm74	6508	16	FT	FT	NNP
cord-015021-pol2qm74	6508	17	BSA	BSA	NNP
cord-015021-pol2qm74	6508	18	burn	burn	NN
cord-015021-pol2qm74	6508	19	;	;	.
cord-015021-pol2qm74	6509	1	32	32	CD
cord-015021-pol2qm74	6509	2	_	_	NN
cord-015021-pol2qm74	6509	3	+	+	SYM
cord-015021-pol2qm74	6509	4	16	16	CD
cord-015021-pol2qm74	6509	5	years	year	NNS
cord-015021-pol2qm74	6509	6	old	old	JJ
cord-015021-pol2qm74	6509	7	)	)	-RRB-
cord-015021-pol2qm74	6509	8	were	be	VBD
cord-015021-pol2qm74	6509	9	studied	study	VBN
cord-015021-pol2qm74	6509	10	serially	serially	RB
cord-015021-pol2qm74	6509	11	for	for	IN
cord-015021-pol2qm74	6509	12	three	three	CD
cord-015021-pol2qm74	6509	13	weeks	week	NNS
cord-015021-pol2qm74	6509	14	post	post	NN
cord-015021-pol2qm74	6509	15	bum	bum	NN
cord-015021-pol2qm74	6509	16	.	.	.
cord-015021-pol2qm74	6510	1	Patients	patient	NNS
cord-015021-pol2qm74	6510	2	underwent	undergo	VBD
cord-015021-pol2qm74	6510	3	partitional	partitional	JJ
cord-015021-pol2qm74	6510	4	calorimetry	calorimetry	NN
cord-015021-pol2qm74	6510	5	to	to	TO
cord-015021-pol2qm74	6510	6	assess	assess	VB
cord-015021-pol2qm74	6510	7	metabolic	metabolic	JJ
cord-015021-pol2qm74	6510	8	rate	rate	NN
cord-015021-pol2qm74	6510	9	and	and	CC
cord-015021-pol2qm74	6510	10	compartmented	compartmented	JJ
cord-015021-pol2qm74	6510	11	heat	heat	NN
cord-015021-pol2qm74	6510	12	loss	loss	NN
cord-015021-pol2qm74	6510	13	.	.	.
cord-015021-pol2qm74	6511	1	Nitrogen	nitrogen	NN
cord-015021-pol2qm74	6511	2	was	be	VBD
cord-015021-pol2qm74	6511	3	assayed	assay	VBN
cord-015021-pol2qm74	6511	4	using	use	VBG
cord-015021-pol2qm74	6511	5	chemiluminescence	chemiluminescence	NN
cord-015021-pol2qm74	6511	6	.	.	.
cord-015021-pol2qm74	6512	1	LPS	LPS	NNP
cord-015021-pol2qm74	6512	2	and	and	CC
cord-015021-pol2qm74	6512	3	I1	I1	NNP
cord-015021-pol2qm74	6512	4	-	-	HYPH
cord-015021-pol2qm74	6512	5	6	6	CD
cord-015021-pol2qm74	6512	6	were	be	VBD
cord-015021-pol2qm74	6512	7	measured	measure	VBN
cord-015021-pol2qm74	6512	8	with	with	IN
cord-015021-pol2qm74	6512	9	Limulus	Limulus	NNP
cord-015021-pol2qm74	6512	10	Amebocyte	Amebocyte	NNP
cord-015021-pol2qm74	6512	11	Lysate	Lysate	NNP
cord-015021-pol2qm74	6512	12	assay	assay	NN
cord-015021-pol2qm74	6512	13	and	and	CC
cord-015021-pol2qm74	6512	14	ELISA	ELISA	NNP
cord-015021-pol2qm74	6512	15	.	.	.
cord-015021-pol2qm74	6513	1	Patients	patient	NNS
cord-015021-pol2qm74	6513	2	were	be	VBD
cord-015021-pol2qm74	6513	3	excluded	exclude	VBN
cord-015021-pol2qm74	6513	4	if	if	IN
cord-015021-pol2qm74	6513	5	they	-PRON-	PRP
cord-015021-pol2qm74	6513	6	suffered	suffer	VBD
cord-015021-pol2qm74	6513	7	smoke	smoke	NN
cord-015021-pol2qm74	6513	8	inhalation	inhalation	NN
cord-015021-pol2qm74	6513	9	,	,	,
cord-015021-pol2qm74	6513	10	showed	show	VBD
cord-015021-pol2qm74	6513	11	any	any	DT
cord-015021-pol2qm74	6513	12	sign	sign	NN
cord-015021-pol2qm74	6513	13	of	of	IN
cord-015021-pol2qm74	6513	14	sepsis	sepsis	NN
cord-015021-pol2qm74	6513	15	or	or	CC
cord-015021-pol2qm74	6513	16	failed	fail	VBD
cord-015021-pol2qm74	6513	17	to	to	TO
cord-015021-pol2qm74	6513	18	rapidly	rapidly	RB
cord-015021-pol2qm74	6513	19	meet	meet	VB
cord-015021-pol2qm74	6513	20	their	-PRON-	PRP$
cord-015021-pol2qm74	6513	21	nutritional	nutritional	JJ
cord-015021-pol2qm74	6513	22	needs	need	NNS
cord-015021-pol2qm74	6513	23	via	via	IN
cord-015021-pol2qm74	6513	24	the	the	DT
cord-015021-pol2qm74	6513	25	enteral	enteral	JJ
cord-015021-pol2qm74	6513	26	route	route	NN
cord-015021-pol2qm74	6513	27	.	.	.
cord-015021-pol2qm74	6514	1	Ten	ten	CD
cord-015021-pol2qm74	6514	2	patients	patient	NNS
cord-015021-pol2qm74	6514	3	received	receive	VBD
cord-015021-pol2qm74	6514	4	intravenous	intravenous	JJ
cord-015021-pol2qm74	6514	5	Polymixin	Polymixin	NNP
cord-015021-pol2qm74	6514	6	B	B	NNP
cord-015021-pol2qm74	6514	7	(	(	-LRB-
cord-015021-pol2qm74	6514	8	5,000	5,000	CD
cord-015021-pol2qm74	6514	9	U	U	NNP
cord-015021-pol2qm74	6514	10	/	/	SYM
cord-015021-pol2qm74	6514	11	kg	kg	NN
cord-015021-pol2qm74	6514	12	/	/	SYM
cord-015021-pol2qm74	6514	13	day	day	NN
cord-015021-pol2qm74	6514	14	to	to	TO
cord-015021-pol2qm74	6514	15	bind	bind	VB
cord-015021-pol2qm74	6514	16	LPS	LPS	NNP
cord-015021-pol2qm74	6514	17	)	)	-RRB-
cord-015021-pol2qm74	6514	18	.	.	.
cord-015021-pol2qm74	6515	1	These	these	DT
cord-015021-pol2qm74	6515	2	patients	patient	NNS
cord-015021-pol2qm74	6515	3	did	do	VBD
cord-015021-pol2qm74	6515	4	not	not	RB
cord-015021-pol2qm74	6515	5	differ	differ	VB
cord-015021-pol2qm74	6515	6	for	for	IN
cord-015021-pol2qm74	6515	7	the	the	DT
cord-015021-pol2qm74	6515	8	remainder	remainder	NN
cord-015021-pol2qm74	6515	9	.	.	.
cord-015021-pol2qm74	6516	1	All	all	DT
cord-015021-pol2qm74	6516	2	patients	patient	NNS
cord-015021-pol2qm74	6516	3	were	be	VBD
cord-015021-pol2qm74	6516	4	hypermetabolic	hypermetabolic	JJ
cord-015021-pol2qm74	6516	5	and	and	CC
cord-015021-pol2qm74	6516	6	febrile	febrile	JJ
cord-015021-pol2qm74	6516	7	in	in	IN
cord-015021-pol2qm74	6516	8	proportion	proportion	NN
cord-015021-pol2qm74	6516	9	to	to	IN
cord-015021-pol2qm74	6516	10	the	the	DT
cord-015021-pol2qm74	6516	11	size	size	NN
cord-015021-pol2qm74	6516	12	of	of	IN
cord-015021-pol2qm74	6516	13	their	-PRON-	PRP$
cord-015021-pol2qm74	6516	14	bum	bum	NN
cord-015021-pol2qm74	6516	15	wound	wound	NN
cord-015021-pol2qm74	6516	16	but	but	CC
cord-015021-pol2qm74	6516	17	were	be	VBD
cord-015021-pol2qm74	6516	18	not	not	RB
cord-015021-pol2qm74	6516	19	endotoxemic	endotoxemic	JJ
cord-015021-pol2qm74	6516	20	(	(	-LRB-
cord-015021-pol2qm74	6516	21	3.1	3.1	CD
cord-015021-pol2qm74	6516	22	+	+	CC
cord-015021-pol2qm74	6516	23	_	_	NN
cord-015021-pol2qm74	6516	24	5.6	5.6	CD
cord-015021-pol2qm74	6516	25	pg	pg	NNP
cord-015021-pol2qm74	6516	26	/	/	SYM
cord-015021-pol2qm74	6516	27	ml	ml	NN
cord-015021-pol2qm74	6516	28	;	;	:
cord-015021-pol2qm74	6516	29	normal	normal	JJ
cord-015021-pol2qm74	6516	30	<	<	XX
cord-015021-pol2qm74	6516	31	40	40	CD
cord-015021-pol2qm74	6516	32	pg	pg	NN
cord-015021-pol2qm74	6516	33	/	/	SYM
cord-015021-pol2qm74	6516	34	ml	ml	NN
cord-015021-pol2qm74	6516	35	)	)	-RRB-
cord-015021-pol2qm74	6516	36	.	.	.
cord-015021-pol2qm74	6517	1	I1	I1	NNP
cord-015021-pol2qm74	6517	2	-	-	HYPH
cord-015021-pol2qm74	6517	3	6	6	NNP
cord-015021-pol2qm74	6517	4	did	do	VBD
cord-015021-pol2qm74	6517	5	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6517	6	a	a	DT
cord-015021-pol2qm74	6517	7	significant	significant	JJ
cord-015021-pol2qm74	6517	8	correlation	correlation	NN
cord-015021-pol2qm74	6517	9	with	with	IN
cord-015021-pol2qm74	6517	10	cole	cole	NNP
cord-015021-pol2qm74	6517	11	temperature	temperature	NN
cord-015021-pol2qm74	6517	12	(	(	-LRB-
cord-015021-pol2qm74	6517	13	Tr~	tr~	NN
cord-015021-pol2qm74	6517	14	=	=	NFP
cord-015021-pol2qm74	6518	1	37.6	37.6	CD
cord-015021-pol2qm74	6518	2	+	+	SYM
cord-015021-pol2qm74	6518	3	0.21ogi1	0.21ogi1	CD
cord-015021-pol2qm74	6518	4	-	-	SYM
cord-015021-pol2qm74	6518	5	6	6	CD
cord-015021-pol2qm74	6518	6	,	,	,
cord-015021-pol2qm74	6518	7	P=0.04	P=0.04	NNP
cord-015021-pol2qm74	6518	8	)	)	-RRB-
cord-015021-pol2qm74	6518	9	and	and	CC
cord-015021-pol2qm74	6518	10	with	with	IN
cord-015021-pol2qm74	6518	11	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6518	12	excretion	excretion	NN
cord-015021-pol2qm74	6518	13	(	(	-LRB-
cord-015021-pol2qm74	6518	14	Nou	Nou	NNP
cord-015021-pol2qm74	6518	15	t	t	NNP
cord-015021-pol2qm74	6518	16	=	=	SYM
cord-015021-pol2qm74	6518	17	-5.2	-5.2	NNP
cord-015021-pol2qm74	6518	18	4	4	CD
cord-015021-pol2qm74	6518	19	-	-	HYPH
cord-015021-pol2qm74	6518	20	0.091ogi1	0.091ogi1	CD
cord-015021-pol2qm74	6518	21	-	-	HYPH
cord-015021-pol2qm74	6518	22	6	6	CD
cord-015021-pol2qm74	6518	23	+	+	SYM
cord-015021-pol2qm74	6518	24	0.14TR	0.14tr	CD
cord-015021-pol2qm74	6518	25	,	,	,
cord-015021-pol2qm74	6518	26	P=0.01	P=0.01	''
cord-015021-pol2qm74	6518	27	)	)	-RRB-
cord-015021-pol2qm74	6518	28	.	.	.
cord-015021-pol2qm74	6519	1	Administration	Administration	NNP
cord-015021-pol2qm74	6519	2	of	of	IN
cord-015021-pol2qm74	6519	3	polymixin	polymixin	NNP
cord-015021-pol2qm74	6519	4	B	B	NNP
cord-015021-pol2qm74	6519	5	had	have	VBD
cord-015021-pol2qm74	6519	6	no	no	DT
cord-015021-pol2qm74	6519	7	effect	effect	NN
cord-015021-pol2qm74	6519	8	on	on	IN
cord-015021-pol2qm74	6519	9	metabolic	metabolic	JJ
cord-015021-pol2qm74	6519	10	rate	rate	NN
cord-015021-pol2qm74	6519	11	,	,	,
cord-015021-pol2qm74	6519	12	temperature	temperature	NN
cord-015021-pol2qm74	6519	13	or	or	CC
cord-015021-pol2qm74	6519	14	I1	i1	NN
cord-015021-pol2qm74	6519	15	-	-	HYPH
cord-015021-pol2qm74	6519	16	6	6	CD
cord-015021-pol2qm74	6519	17	levels	level	NNS
cord-015021-pol2qm74	6519	18	but	but	CC
cord-015021-pol2qm74	6519	19	did	do	VBD
cord-015021-pol2qm74	6519	20	reduce	reduce	VB
cord-015021-pol2qm74	6519	21	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6519	22	excretion	excretion	NN
cord-015021-pol2qm74	6519	23	resulting	result	VBG
cord-015021-pol2qm74	6519	24	in	in	IN
cord-015021-pol2qm74	6519	25	more	more	RBR
cord-015021-pol2qm74	6519	26	positive	positive	JJ
cord-015021-pol2qm74	6519	27	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6519	28	balance	balance	NN
cord-015021-pol2qm74	6519	29	(	(	-LRB-
cord-015021-pol2qm74	6519	30	0.t	0.t	CD
cord-015021-pol2qm74	6519	31	grn	grn	NNP
cord-015021-pol2qm74	6519	32	/	/	SYM
cord-015021-pol2qm74	6519	33	day	day	NN
cord-015021-pol2qm74	6519	34	vs.	vs.	FW
cord-015021-pol2qm74	6519	35	-0.1	-0.1	CD
cord-015021-pol2qm74	6519	36	gm	gm	NNP
cord-015021-pol2qm74	6519	37	/	/	SYM
cord-015021-pol2qm74	6519	38	day	day	NN
cord-015021-pol2qm74	6519	39	,	,	,
cord-015021-pol2qm74	6519	40	P=0.04	P=0.04	NNP
cord-015021-pol2qm74	6519	41	)	)	-RRB-
cord-015021-pol2qm74	6519	42	.	.	.
cord-015021-pol2qm74	6520	1	Although	although	IN
cord-015021-pol2qm74	6520	2	bum	bum	JJ
cord-015021-pol2qm74	6520	3	injury	injury	NN
cord-015021-pol2qm74	6520	4	does	do	VBZ
cord-015021-pol2qm74	6520	5	not	not	RB
cord-015021-pol2qm74	6520	6	produce	produce	VB
cord-015021-pol2qm74	6520	7	an	an	DT
cord-015021-pol2qm74	6520	8	obligatory	obligatory	JJ
cord-015021-pol2qm74	6520	9	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	6520	10	,	,	,
cord-015021-pol2qm74	6520	11	I1	i1	NN
cord-015021-pol2qm74	6520	12	-	-	HYPH
cord-015021-pol2qm74	6520	13	6	6	NNP
cord-015021-pol2qm74	6520	14	does	do	VBZ
cord-015021-pol2qm74	6520	15	appear	appear	VB
cord-015021-pol2qm74	6520	16	to	to	TO
cord-015021-pol2qm74	6520	17	play	play	VB
cord-015021-pol2qm74	6520	18	a	a	DT
cord-015021-pol2qm74	6520	19	role	role	NN
cord-015021-pol2qm74	6520	20	in	in	IN
cord-015021-pol2qm74	6520	21	the	the	DT
cord-015021-pol2qm74	6520	22	fever	fever	NN
cord-015021-pol2qm74	6520	23	and	and	CC
cord-015021-pol2qm74	6520	24	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6520	25	wasting	wasting	NN
cord-015021-pol2qm74	6520	26	seen	see	VBN
cord-015021-pol2qm74	6520	27	with	with	IN
cord-015021-pol2qm74	6520	28	such	such	JJ
cord-015021-pol2qm74	6520	29	injuries	injury	NNS
cord-015021-pol2qm74	6520	30	.	.	.
cord-015021-pol2qm74	6521	1	The	the	DT
cord-015021-pol2qm74	6521	2	effect	effect	NN
cord-015021-pol2qm74	6521	3	ofPolymixin	ofPolymixin	NNP
cord-015021-pol2qm74	6521	4	B	B	NNP
cord-015021-pol2qm74	6521	5	on	on	IN
cord-015021-pol2qm74	6521	6	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6521	7	excretion	excretion	NN
cord-015021-pol2qm74	6521	8	suggests	suggest	VBZ
cord-015021-pol2qm74	6521	9	that	that	IN
cord-015021-pol2qm74	6521	10	LPS	LPS	NNP
cord-015021-pol2qm74	6521	11	may	may	MD
cord-015021-pol2qm74	6521	12	play	play	VB
cord-015021-pol2qm74	6521	13	a	a	DT
cord-015021-pol2qm74	6521	14	role	role	NN
cord-015021-pol2qm74	6521	15	either	either	CC
cord-015021-pol2qm74	6521	16	locally	locally	RB
cord-015021-pol2qm74	6521	17	or	or	CC
cord-015021-pol2qm74	6521	18	in	in	IN
cord-015021-pol2qm74	6521	19	the	the	DT
cord-015021-pol2qm74	6521	20	portal	portal	JJ
cord-015021-pol2qm74	6521	21	system	system	NN
cord-015021-pol2qm74	6521	22	.	.	.
cord-015021-pol2qm74	6522	1	Introduction	introduction	NN
cord-015021-pol2qm74	6522	2	:	:	:
cord-015021-pol2qm74	6523	1	There	there	EX
cord-015021-pol2qm74	6523	2	is	be	VBZ
cord-015021-pol2qm74	6523	3	substantial	substantial	JJ
cord-015021-pol2qm74	6523	4	evidence	evidence	NN
cord-015021-pol2qm74	6523	5	that	that	WDT
cord-015021-pol2qm74	6523	6	release	release	NN
cord-015021-pol2qm74	6523	7	of	of	IN
cord-015021-pol2qm74	6523	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6523	9	mediators	mediator	NNS
cord-015021-pol2qm74	6523	10	by	by	IN
cord-015021-pol2qm74	6523	11	activated	activate	VBN
cord-015021-pol2qm74	6523	12	Kupffer	Kupffer	NNP
cord-015021-pol2qm74	6523	13	cells	cell	NNS
cord-015021-pol2qm74	6523	14	contribute	contribute	VBP
cord-015021-pol2qm74	6523	15	to	to	IN
cord-015021-pol2qm74	6523	16	the	the	DT
cord-015021-pol2qm74	6523	17	course	course	NN
cord-015021-pol2qm74	6523	18	of	of	IN
cord-015021-pol2qm74	6523	19	a	a	DT
cord-015021-pol2qm74	6523	20	systemic	systemic	JJ
cord-015021-pol2qm74	6523	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6523	22	process	process	NN
cord-015021-pol2qm74	6523	23	,	,	,
cord-015021-pol2qm74	6523	24	e.g.	e.g.	RB
cord-015021-pol2qm74	6523	25	after	after	IN
cord-015021-pol2qm74	6523	26	shock	shock	NN
cord-015021-pol2qm74	6523	27	or	or	CC
cord-015021-pol2qm74	6523	28	lrauma	lrauma	NN
cord-015021-pol2qm74	6523	29	.	.	.
cord-015021-pol2qm74	6524	1	Besides	besides	IN
cord-015021-pol2qm74	6524	2	the	the	DT
cord-015021-pol2qm74	6524	3	systemic	systemic	JJ
cord-015021-pol2qm74	6524	4	effects	effect	NNS
cord-015021-pol2qm74	6524	5	of	of	IN
cord-015021-pol2qm74	6524	6	mediators	mediator	NNS
cord-015021-pol2qm74	6524	7	such	such	JJ
cord-015021-pol2qm74	6524	8	as	as	IN
cord-015021-pol2qm74	6524	9	TNF	TNF	NNP
cord-015021-pol2qm74	6524	10	,	,	,
cord-015021-pol2qm74	6524	11	PAF	PAF	NNP
cord-015021-pol2qm74	6524	12	or	or	CC
cord-015021-pol2qm74	6524	13	interleukines	interleukine	NNS
cord-015021-pol2qm74	6524	14	,	,	,
cord-015021-pol2qm74	6524	15	local	local	JJ
cord-015021-pol2qm74	6524	16	actions	action	NNS
cord-015021-pol2qm74	6524	17	on	on	IN
cord-015021-pol2qm74	6524	18	hepatic	hepatic	JJ
cord-015021-pol2qm74	6524	19	microvasculature	microvasculature	NN
cord-015021-pol2qm74	6524	20	and	and	CC
cord-015021-pol2qm74	6524	21	hepatic	hepatic	JJ
cord-015021-pol2qm74	6524	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6524	23	response	response	NN
cord-015021-pol2qm74	6524	24	have	have	VBP
cord-015021-pol2qm74	6524	25	to	to	TO
cord-015021-pol2qm74	6524	26	be	be	VB
cord-015021-pol2qm74	6524	27	considered	consider	VBN
cord-015021-pol2qm74	6524	28	.	.	.
cord-015021-pol2qm74	6525	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	6525	2	aim	aim	NN
cord-015021-pol2qm74	6525	3	was	be	VBD
cord-015021-pol2qm74	6525	4	to	to	TO
cord-015021-pol2qm74	6525	5	assess	assess	VB
cord-015021-pol2qm74	6525	6	the	the	DT
cord-015021-pol2qm74	6525	7	role	role	NN
cord-015021-pol2qm74	6525	8	of	of	IN
cord-015021-pol2qm74	6525	9	TNF	TNF	NNP
cord-015021-pol2qm74	6525	10	and	and	CC
cord-015021-pol2qm74	6525	11	PAF	PAF	NNP
cord-015021-pol2qm74	6525	12	by	by	IN
cord-015021-pol2qm74	6525	13	blocking	block	VBG
cord-015021-pol2qm74	6525	14	their	-PRON-	PRP$
cord-015021-pol2qm74	6525	15	effects	effect	NNS
cord-015021-pol2qm74	6525	16	using	use	VBG
cord-015021-pol2qm74	6525	17	anti	anti	JJ
cord-015021-pol2qm74	6525	18	-	-	JJ
cord-015021-pol2qm74	6525	19	TNF	tnf	JJ
cord-015021-pol2qm74	6525	20	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	6525	21	antibody	antibody	NN
cord-015021-pol2qm74	6525	22	,	,	,
cord-015021-pol2qm74	6525	23	pentoxifylline	pentoxifylline	NNP
cord-015021-pol2qm74	6525	24	and	and	CC
cord-015021-pol2qm74	6525	25	a	a	DT
cord-015021-pol2qm74	6525	26	PAF	PAF	NNP
cord-015021-pol2qm74	6525	27	antagonist	antagonist	NN
cord-015021-pol2qm74	6525	28	.	.	.
cord-015021-pol2qm74	6526	1	Methnds	methnd	NNS
cord-015021-pol2qm74	6526	2	:	:	:
cord-015021-pol2qm74	6527	1	In	in	IN
cord-015021-pol2qm74	6527	2	anesthetized	anesthetized	JJ
cord-015021-pol2qm74	6527	3	SPRD	SPRD	NNS
cord-015021-pol2qm74	6527	4	-	-	HYPH
cord-015021-pol2qm74	6527	5	rats	rat	NNS
cord-015021-pol2qm74	6527	6	,	,	,
cord-015021-pol2qm74	6527	7	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	6527	8	shock	shock	NN
cord-015021-pol2qm74	6527	9	was	be	VBD
cord-015021-pol2qm74	6527	10	induced	induce	VBN
cord-015021-pol2qm74	6527	11	by	by	IN
cord-015021-pol2qm74	6527	12	withdrawl	withdrawl	NN
cord-015021-pol2qm74	6527	13	of	of	IN
cord-015021-pol2qm74	6527	14	arterial	arterial	JJ
cord-015021-pol2qm74	6527	15	blood	blood	NN
cord-015021-pol2qm74	6527	16	within	within	IN
cord-015021-pol2qm74	6527	17	5	5	CD
cord-015021-pol2qm74	6527	18	rain	rain	NN
cord-015021-pol2qm74	6527	19	and	and	CC
cord-015021-pol2qm74	6527	20	shock	shock	NN
cord-015021-pol2qm74	6527	21	state	state	NN
cord-015021-pol2qm74	6527	22	was	be	VBD
cord-015021-pol2qm74	6527	23	hold	hold	NN
cord-015021-pol2qm74	6527	24	for	for	IN
cord-015021-pol2qm74	6527	25	1	1	CD
cord-015021-pol2qm74	6527	26	h	h	NN
cord-015021-pol2qm74	6527	27	at	at	IN
cord-015021-pol2qm74	6527	28	a	a	DT
cord-015021-pol2qm74	6527	29	MAP	MAP	NNP
cord-015021-pol2qm74	6527	30	of	of	IN
cord-015021-pol2qm74	6527	31	40	40	CD
cord-015021-pol2qm74	6527	32	mm	mm	NN
cord-015021-pol2qm74	6527	33	Hg	hg	NN
cord-015021-pol2qm74	6527	34	(	(	-LRB-
cord-015021-pol2qm74	6527	35	cardiac	cardiac	JJ
cord-015021-pol2qm74	6527	36	output	output	NN
cord-015021-pol2qm74	6527	37	of	of	IN
cord-015021-pol2qm74	6527	38	50	50	CD
cord-015021-pol2qm74	6527	39	%	%	NN
cord-015021-pol2qm74	6527	40	)	)	-RRB-
cord-015021-pol2qm74	6527	41	.	.	.
cord-015021-pol2qm74	6528	1	Following	follow	VBG
cord-015021-pol2qm74	6528	2	adequate	adequate	JJ
cord-015021-pol2qm74	6528	3	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6528	4	with	with	IN
cord-015021-pol2qm74	6528	5	60	60	CD
cord-015021-pol2qm74	6528	6	%	%	NN
cord-015021-pol2qm74	6528	7	of	of	IN
cord-015021-pol2qm74	6528	8	shed	shed	JJ
cord-015021-pol2qm74	6528	9	blood	blood	NN
cord-015021-pol2qm74	6528	10	and	and	CC
cord-015021-pol2qm74	6528	11	twice	twice	RB
cord-015021-pol2qm74	6528	12	of	of	IN
cord-015021-pol2qm74	6528	13	this	this	DT
cord-015021-pol2qm74	6528	14	volume	volume	NN
cord-015021-pol2qm74	6528	15	as	as	IN
cord-015021-pol2qm74	6528	16	Ringer	Ringer	NNP
cord-015021-pol2qm74	6528	17	's	's	POS
cord-015021-pol2qm74	6528	18	solntion	solntion	NN
cord-015021-pol2qm74	6528	19	,	,	,
cord-015021-pol2qm74	6528	20	animals	animal	NNS
cord-015021-pol2qm74	6528	21	recovered	recover	VBD
cord-015021-pol2qm74	6528	22	to	to	IN
cord-015021-pol2qm74	6528	23	MAP	MAP	NNP
cord-015021-pol2qm74	6529	1	>	>	XX
cord-015021-pol2qm74	6530	1	1130	1130	CD
cord-015021-pol2qm74	6530	2	mm	mm	NNP
cord-015021-pol2qm74	6530	3	Hg	Hg	NNP
cord-015021-pol2qm74	6530	4	and	and	CC
cord-015021-pol2qm74	6530	5	CO	co	NN
cord-015021-pol2qm74	6530	6	>	>	XX
cord-015021-pol2qm74	6530	7	120	120	CD
cord-015021-pol2qm74	6530	8	%	%	NN
cord-015021-pol2qm74	6530	9	.	.	.
cord-015021-pol2qm74	6531	1	Hepatic	hepatic	JJ
cord-015021-pol2qm74	6531	2	microcirculation	microcirculation	NN
cord-015021-pol2qm74	6531	3	and	and	CC
cord-015021-pol2qm74	6531	4	sinusoidal	sinusoidal	JJ
cord-015021-pol2qm74	6531	5	leukocyte	leukocyte	NN
cord-015021-pol2qm74	6531	6	-	-	HYPH
cord-015021-pol2qm74	6531	7	endothelium	endothelium	NN
cord-015021-pol2qm74	6531	8	interactions	interaction	NNS
cord-015021-pol2qm74	6531	9	were	be	VBD
cord-015021-pol2qm74	6531	10	examined	examine	VBN
cord-015021-pol2qm74	6531	11	by	by	IN
cord-015021-pol2qm74	6531	12	intravital	intravital	NNP
cord-015021-pol2qm74	6531	13	epi	epi	NNP
cord-015021-pol2qm74	6531	14	-	-	HYPH
cord-015021-pol2qm74	6531	15	fluorescence	fluorescence	NN
cord-015021-pol2qm74	6531	16	microscopy	microscopy	NNS
cord-015021-pol2qm74	6531	17	at	at	IN
cord-015021-pol2qm74	6531	18	1	1	CD
cord-015021-pol2qm74	6531	19	,	,	,
cord-015021-pol2qm74	6531	20	3	3	CD
cord-015021-pol2qm74	6531	21	,	,	,
cord-015021-pol2qm74	6531	22	or	or	CC
cord-015021-pol2qm74	6531	23	5	5	CD
cord-015021-pol2qm74	6531	24	hours	hour	NNS
cord-015021-pol2qm74	6531	25	after	after	IN
cord-015021-pol2qm74	6531	26	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6531	27	.	.	.
cord-015021-pol2qm74	6532	1	In	in	IN
cord-015021-pol2qm74	6532	2	a	a	DT
cord-015021-pol2qm74	6532	3	blinded	blinded	JJ
cord-015021-pol2qm74	6532	4	fashion	fashion	NN
cord-015021-pol2qm74	6532	5	,	,	,
cord-015021-pol2qm74	6532	6	a	a	DT
cord-015021-pol2qm74	6532	7	rat	rat	NN
cord-015021-pol2qm74	6532	8	-	-	HYPH
cord-015021-pol2qm74	6532	9	specific	specific	JJ
cord-015021-pol2qm74	6532	10	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	6532	11	anti	anti	JJ
cord-015021-pol2qm74	6532	12	-	-	JJ
cord-015021-pol2qm74	6532	13	TNF	tnf	JJ
cord-015021-pol2qm74	6532	14	antibody	antibody	NN
cord-015021-pol2qm74	6532	15	[	[	-LRB-
cord-015021-pol2qm74	6532	16	2	2	CD
cord-015021-pol2qm74	6532	17	mg	mg	NNP
cord-015021-pol2qm74	6532	18	/	/	SYM
cord-015021-pol2qm74	6532	19	kg	kg	NNP
cord-015021-pol2qm74	6532	20	,	,	,
cord-015021-pol2qm74	6532	21	Celltech	Celltech	NNP
cord-015021-pol2qm74	6532	22	,	,	,
cord-015021-pol2qm74	6532	23	UK	UK	NNP
cord-015021-pol2qm74	6532	24	)	)	-RRB-
cord-015021-pol2qm74	6532	25	,	,	,
cord-015021-pol2qm74	6532	26	pentoxffylline	pentoxffylline	NNP
cord-015021-pol2qm74	6532	27	(	(	-LRB-
cord-015021-pol2qm74	6532	28	PTX	PTX	NNP
cord-015021-pol2qm74	6532	29	,	,	,
cord-015021-pol2qm74	6532	30	50	50	CD
cord-015021-pol2qm74	6532	31	mg	mg	NNP
cord-015021-pol2qm74	6532	32	/	/	SYM
cord-015021-pol2qm74	6532	33	kg	kg	NNS
cord-015021-pol2qm74	6532	34	,	,	,
cord-015021-pol2qm74	6532	35	Hoechst	Hoechst	NNP
cord-015021-pol2qm74	6532	36	,	,	,
cord-015021-pol2qm74	6532	37	D	D	NNP
cord-015021-pol2qm74	6532	38	)	)	-RRB-
cord-015021-pol2qm74	6532	39	,	,	,
cord-015021-pol2qm74	6532	40	and	and	CC
cord-015021-pol2qm74	6532	41	a	a	DT
cord-015021-pol2qm74	6532	42	PAF	PAF	NNP
cord-015021-pol2qm74	6532	43	antagonist	antagonist	NN
cord-015021-pol2qm74	6532	44	(	(	-LRB-
cord-015021-pol2qm74	6532	45	WEB	web	NN
cord-015021-pol2qm74	6532	46	2086	2086	CD
cord-015021-pol2qm74	6532	47	,	,	,
cord-015021-pol2qm74	6532	48	Boehringer	Boehringer	NNP
cord-015021-pol2qm74	6532	49	,	,	,
cord-015021-pol2qm74	6532	50	Ingh	Ingh	NNP
cord-015021-pol2qm74	6532	51	.	.	.
cord-015021-pol2qm74	6532	52	,	,	,
cord-015021-pol2qm74	6532	53	D	D	NNP
cord-015021-pol2qm74	6532	54	)	)	-RRB-
cord-015021-pol2qm74	6532	55	were	be	VBD
cord-015021-pol2qm74	6532	56	given	give	VBN
cord-015021-pol2qm74	6532	57	either	either	CC
cord-015021-pol2qm74	6532	58	as	as	IN
cord-015021-pol2qm74	6532	59	pretreatment	pretreatment	NN
cord-015021-pol2qm74	6532	60	or	or	CC
cord-015021-pol2qm74	6532	61	at	at	IN
cord-015021-pol2qm74	6532	62	the	the	DT
cord-015021-pol2qm74	6532	63	time	time	NN
cord-015021-pol2qm74	6532	64	of	of	IN
cord-015021-pol2qm74	6532	65	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6532	66	(	(	-LRB-
cord-015021-pol2qm74	6532	67	n=6	n=6	JJ
cord-015021-pol2qm74	6532	68	-	-	HYPH
cord-015021-pol2qm74	6532	69	8	8	CD
cord-015021-pol2qm74	6532	70	group	group	NN
cord-015021-pol2qm74	6532	71	Bolla	Bolla	NNP
cord-015021-pol2qm74	6532	72	.	.	.
cord-015021-pol2qm74	6533	1	K	K	NNP
cord-015021-pol2qm74	6533	2	*	*	NFP
cord-015021-pol2qm74	6533	3	.	.	.
cord-015021-pol2qm74	6533	4	,	,	,
cord-015021-pol2qm74	6533	5	Duchateau	Duchateau	NNP
cord-015021-pol2qm74	6533	6	,	,	,
cord-015021-pol2qm74	6533	7	J.	J.	NNP
cord-015021-pol2qm74	6533	8	,	,	,
cord-015021-pol2qm74	6533	9	HajOs	HajOs	NNP
cord-015021-pol2qm74	6533	10	,	,	,
cord-015021-pol2qm74	6533	11	Gy	Gy	NNP
cord-015021-pol2qm74	6533	12	.	.	NNP
cord-015021-pol2qm74	6533	13	,	,	,
cord-015021-pol2qm74	6533	14	Mbzes	Mbzes	NNP
cord-015021-pol2qm74	6533	15	,	,	,
cord-015021-pol2qm74	6533	16	T.	T.	NNP
cord-015021-pol2qm74	6533	17	,	,	,
cord-015021-pol2qm74	6533	18	Hern	Hern	NNP
cord-015021-pol2qm74	6533	19	~	~	NNP
cord-015021-pol2qm74	6533	20	di	di	NNP
cord-015021-pol2qm74	6533	21	,	,	,
cord-015021-pol2qm74	6533	22	F.	F.	NNP
cord-015021-pol2qm74	6533	23	Prevention	Prevention	NNP
cord-015021-pol2qm74	6533	24	of	of	IN
cord-015021-pol2qm74	6533	25	temporary	temporary	JJ
cord-015021-pol2qm74	6533	26	/	/	SYM
cord-015021-pol2qm74	6533	27	secondary	secondary	JJ
cord-015021-pol2qm74	6533	28	immune	immune	JJ
cord-015021-pol2qm74	6533	29	deficiencies	deficiency	NNS
cord-015021-pol2qm74	6533	30	or	or	CC
cord-015021-pol2qm74	6533	31	reduction	reduction	NN
cord-015021-pol2qm74	6533	32	of	of	IN
cord-015021-pol2qm74	6533	33	their	-PRON-	PRP$
cord-015021-pol2qm74	6533	34	severity	severity	NN
cord-015021-pol2qm74	6533	35	and/or	and/or	CC
cord-015021-pol2qm74	6533	36	duration	duration	NN
cord-015021-pol2qm74	6533	37	as	as	RB
cord-015021-pol2qm74	6533	38	well	well	RB
cord-015021-pol2qm74	6533	39	as	as	IN
cord-015021-pol2qm74	6533	40	the	the	DT
cord-015021-pol2qm74	6533	41	reduction	reduction	NN
cord-015021-pol2qm74	6533	42	of	of	IN
cord-015021-pol2qm74	6533	43	the	the	DT
cord-015021-pol2qm74	6533	44	perifocal	perifocal	JJ
cord-015021-pol2qm74	6533	45	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6533	46	processes	process	NNS
cord-015021-pol2qm74	6533	47	belong	belong	VBP
cord-015021-pol2qm74	6533	48	to	to	IN
cord-015021-pol2qm74	6533	49	the	the	DT
cord-015021-pol2qm74	6533	50	rational	rational	JJ
cord-015021-pol2qm74	6533	51	targets	target	NNS
cord-015021-pol2qm74	6533	52	of	of	IN
cord-015021-pol2qm74	6533	53	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	6533	54	/	/	SYM
cord-015021-pol2qm74	6533	55	pedsurgical	pedsurgical	JJ
cord-015021-pol2qm74	6533	56	medication	medication	NN
cord-015021-pol2qm74	6533	57	.	.	.
cord-015021-pol2qm74	6534	1	Such	such	PDT
cord-015021-pol2qm74	6534	2	a	a	DT
cord-015021-pol2qm74	6534	3	targeted	target	VBN
cord-015021-pol2qm74	6534	4	medication	medication	NN
cord-015021-pol2qm74	6534	5	can	can	MD
cord-015021-pol2qm74	6534	6	result	result	VB
cord-015021-pol2qm74	6534	7	in	in	IN
cord-015021-pol2qm74	6534	8	less	less	RBR
cord-015021-pol2qm74	6534	9	frequently	frequently	RB
cord-015021-pol2qm74	6534	10	occurring	occur	VBG
cord-015021-pol2qm74	6534	11	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	6534	12	infections	infection	NNS
cord-015021-pol2qm74	6534	13	,	,	,
cord-015021-pol2qm74	6534	14	and	and	CC
cord-015021-pol2qm74	6534	15	in	in	IN
cord-015021-pol2qm74	6534	16	reducing	reduce	VBG
cord-015021-pol2qm74	6534	17	the	the	DT
cord-015021-pol2qm74	6534	18	duration	duration	NN
cord-015021-pol2qm74	6534	19	of	of	IN
cord-015021-pol2qm74	6534	20	the	the	DT
cord-015021-pol2qm74	6534	21	intensive	intensive	JJ
cord-015021-pol2qm74	6534	22	care	care	NN
cord-015021-pol2qm74	6534	23	and	and	CC
cord-015021-pol2qm74	6534	24	convalescence	convalescence	NN
cord-015021-pol2qm74	6534	25	period	period	NN
cord-015021-pol2qm74	6534	26	.	.	.
cord-015021-pol2qm74	6535	1	The	the	DT
cord-015021-pol2qm74	6535	2	results	result	NNS
cord-015021-pol2qm74	6535	3	of	of	IN
cord-015021-pol2qm74	6535	4	in	in	FW
cord-015021-pol2qm74	6535	5	vitro	vitro	FW
cord-015021-pol2qm74	6535	6	studies	study	NNS
cord-015021-pol2qm74	6535	7	performed	perform	VBN
cord-015021-pol2qm74	6535	8	with	with	IN
cord-015021-pol2qm74	6535	9	the	the	DT
cord-015021-pol2qm74	6535	10	amino	amino	NN
cord-015021-pol2qm74	6535	11	acid	acid	NN
cord-015021-pol2qm74	6535	12	sequence	sequence	NN
cord-015021-pol2qm74	6535	13	32	32	CD
cord-015021-pol2qm74	6535	14	-	-	SYM
cord-015021-pol2qm74	6535	15	35	35	CD
cord-015021-pol2qm74	6535	16	of	of	IN
cord-015021-pol2qm74	6535	17	thymopoietin	thymopoietin	NNS
cord-015021-pol2qm74	6535	18	,	,	,
cord-015021-pol2qm74	6535	19	i.e.	i.e.	FW
cord-015021-pol2qm74	6535	20	,	,	,
cord-015021-pol2qm74	6535	21	with	with	IN
cord-015021-pol2qm74	6535	22	thymocartin	thymocartin	NNS
cord-015021-pol2qm74	6535	23	in	in	IN
cord-015021-pol2qm74	6535	24	whole	whole	JJ
cord-015021-pol2qm74	6535	25	blood	blood	NN
cord-015021-pol2qm74	6535	26	and	and	CC
cord-015021-pol2qm74	6535	27	peripheral	peripheral	JJ
cord-015021-pol2qm74	6535	28	mono	mono	JJ
cord-015021-pol2qm74	6535	29	-	-	HYPH
cord-015021-pol2qm74	6535	30	nuclear	nuclear	JJ
cord-015021-pol2qm74	6535	31	celI(PBNC	celi(pbnc	CD
cord-015021-pol2qm74	6535	32	)	)	-RRB-
cord-015021-pol2qm74	6536	1	cultures	culture	NNS
cord-015021-pol2qm74	6536	2	clearly	clearly	RB
cord-015021-pol2qm74	6536	3	show	show	VBP
cord-015021-pol2qm74	6536	4	some	some	DT
cord-015021-pol2qm74	6536	5	characteristic	characteristic	JJ
cord-015021-pol2qm74	6536	6	effects	effect	NNS
cord-015021-pol2qm74	6536	7	of	of	IN
cord-015021-pol2qm74	6536	8	this	this	DT
cord-015021-pol2qm74	6536	9	immunomodulator	immunomodulator	NN
cord-015021-pol2qm74	6536	10	.	.	.
cord-015021-pol2qm74	6537	1	Preincubation	preincubation	NN
cord-015021-pol2qm74	6537	2	with	with	IN
cord-015021-pol2qm74	6537	3	the	the	DT
cord-015021-pol2qm74	6537	4	tetrapeptide	tetrapeptide	NN
cord-015021-pol2qm74	6537	5	significantly	significantly	RB
cord-015021-pol2qm74	6537	6	(	(	-LRB-
cord-015021-pol2qm74	6537	7	p	p	NN
cord-015021-pol2qm74	6537	8	<	<	XX
cord-015021-pol2qm74	6537	9	O.Ol	O.Ol	NNP
cord-015021-pol2qm74	6537	10	)	)	-RRB-
cord-015021-pol2qm74	6537	11	and	and	CC
cord-015021-pol2qm74	6537	12	concentration	concentration	NN
cord-015021-pol2qm74	6537	13	-	-	HYPH
cord-015021-pol2qm74	6537	14	dependent	dependent	JJ
cord-015021-pol2qm74	6537	15	reduced	reduce	VBD
cord-015021-pol2qm74	6537	16	the	the	DT
cord-015021-pol2qm74	6537	17	endotoxin(LPS)-induced	endotoxin(LPS)-induced	NNP
cord-015021-pol2qm74	6537	18	TNFalfa	TNFalfa	NNP
cord-015021-pol2qm74	6537	19	production	production	NN
cord-015021-pol2qm74	6537	20	from	from	IN
cord-015021-pol2qm74	6537	21	95,7	95,7	CD
cord-015021-pol2qm74	6537	22	to	to	IN
cord-015021-pol2qm74	6537	23	about	about	IN
cord-015021-pol2qm74	6537	24	20	20	CD
cord-015021-pol2qm74	6537	25	pglml	pglml	NNS
cord-015021-pol2qm74	6537	26	,	,	,
cord-015021-pol2qm74	6537	27	but	but	CC
cord-015021-pol2qm74	6537	28	did	do	VBD
cord-015021-pol2qm74	6537	29	not	not	RB
cord-015021-pol2qm74	6537	30	abolish	abolish	VB
cord-015021-pol2qm74	6537	31	it	-PRON-	PRP
cord-015021-pol2qm74	6537	32	.	.	.
cord-015021-pol2qm74	6538	1	The	the	DT
cord-015021-pol2qm74	6538	2	inhibition	inhibition	NN
cord-015021-pol2qm74	6538	3	of	of	IN
cord-015021-pol2qm74	6538	4	the	the	DT
cord-015021-pol2qm74	6538	5	LPS(0.1	LPS(0.1	NNP
cord-015021-pol2qm74	6538	6	ug	ug	NNP
cord-015021-pol2qm74	6538	7	/	/	SYM
cord-015021-pol2qm74	6538	8	ml)-induced	ml)-induced	NNP
cord-015021-pol2qm74	6538	9	TNF	TNF	NNP
cord-015021-pol2qm74	6538	10	production	production	NN
cord-015021-pol2qm74	6538	11	occured	occur	VBD
cord-015021-pol2qm74	6538	12	already	already	RB
cord-015021-pol2qm74	6538	13	in	in	IN
cord-015021-pol2qm74	6538	14	presence	presence	NN
cord-015021-pol2qm74	6538	15	of	of	IN
cord-015021-pol2qm74	6538	16	0,1	0,1	CD
cord-015021-pol2qm74	6538	17	pg	pg	NNP
cord-015021-pol2qm74	6538	18	peptide	peptide	NNP
cord-015021-pol2qm74	6538	19	/	/	SYM
cord-015021-pol2qm74	6538	20	ml	ml	NN
cord-015021-pol2qm74	6538	21	and	and	CC
cord-015021-pol2qm74	6538	22	peaked	peak	VBD
cord-015021-pol2qm74	6538	23	at	at	IN
cord-015021-pol2qm74	6538	24	the	the	DT
cord-015021-pol2qm74	6538	25	concentration	concentration	NN
cord-015021-pol2qm74	6538	26	of	of	IN
cord-015021-pol2qm74	6538	27	0,01	0,01	NN
cord-015021-pol2qm74	6538	28	ng	ng	NNP
cord-015021-pol2qm74	6538	29	/	/	SYM
cord-015021-pol2qm74	6538	30	ml	ml	NN
cord-015021-pol2qm74	6538	31	.	.	.
cord-015021-pol2qm74	6539	1	Higher	high	JJR
cord-015021-pol2qm74	6539	2	concentrations	concentration	NNS
cord-015021-pol2qm74	6539	3	did	do	VBD
cord-015021-pol2qm74	6539	4	not	not	RB
cord-015021-pol2qm74	6539	5	increase	increase	VB
cord-015021-pol2qm74	6539	6	this	this	DT
cord-015021-pol2qm74	6539	7	effect	effect	NN
cord-015021-pol2qm74	6539	8	.	.	.
cord-015021-pol2qm74	6540	1	In	in	IN
cord-015021-pol2qm74	6540	2	contrast	contrast	NN
cord-015021-pol2qm74	6540	3	to	to	IN
cord-015021-pol2qm74	6540	4	the	the	DT
cord-015021-pol2qm74	6540	5	other	other	JJ
cord-015021-pol2qm74	6540	6	two	two	CD
cord-015021-pol2qm74	6540	7	small	small	JJ
cord-015021-pol2qm74	6540	8	thymic	thymic	JJ
cord-015021-pol2qm74	6540	9	peptides	peptide	NNS
cord-015021-pol2qm74	6540	10	(	(	-LRB-
cord-015021-pol2qm74	6540	11	TP-3	TP-3	NNP
cord-015021-pol2qm74	6540	12	and	and	CC
cord-015021-pol2qm74	6540	13	TP-5	TP-5	NNP
cord-015021-pol2qm74	6540	14	)	)	-RRB-
cord-015021-pol2qm74	6540	15	,	,	,
cord-015021-pol2qm74	6540	16	thymocartin	thymocartin	NNP
cord-015021-pol2qm74	6540	17	did	do	VBD
cord-015021-pol2qm74	6540	18	not	not	RB
cord-015021-pol2qm74	6540	19	enhanced	enhance	VBN
cord-015021-pol2qm74	6540	20	the	the	DT
cord-015021-pol2qm74	6540	21	PWM	PWM	NNP
cord-015021-pol2qm74	6540	22	-	-	HYPH
cord-015021-pol2qm74	6540	23	induced	induce	VBN
cord-015021-pol2qm74	6540	24	PGE	PGE	NNP
cord-015021-pol2qm74	6540	25	2	2	CD
cord-015021-pol2qm74	6540	26	production	production	NN
cord-015021-pol2qm74	6540	27	in	in	IN
cord-015021-pol2qm74	6540	28	PBMC	PBMC	NNP
cord-015021-pol2qm74	6540	29	cultures	culture	NNS
cord-015021-pol2qm74	6540	30	up	up	RP
cord-015021-pol2qm74	6540	31	to	to	IN
cord-015021-pol2qm74	6540	32	a	a	DT
cord-015021-pol2qm74	6540	33	concentration	concentration	NN
cord-015021-pol2qm74	6540	34	of	of	IN
cord-015021-pol2qm74	6540	35	1	1	CD
cord-015021-pol2qm74	6540	36	ng	ng	NN
cord-015021-pol2qm74	6540	37	/	/	SYM
cord-015021-pol2qm74	6540	38	ml	ml	NN
cord-015021-pol2qm74	6540	39	,	,	,
cord-015021-pol2qm74	6540	40	inclusive	inclusive	JJ
cord-015021-pol2qm74	6540	41	.	.	.
cord-015021-pol2qm74	6541	1	The	the	DT
cord-015021-pol2qm74	6541	2	selection	selection	NN
cord-015021-pol2qm74	6541	3	of	of	IN
cord-015021-pol2qm74	6541	4	thymocartin	thymocartin	NNP
cord-015021-pol2qm74	6541	5	(	(	-LRB-
cord-015021-pol2qm74	6541	6	TP-4	TP-4	NNP
cord-015021-pol2qm74	6541	7	)	)	-RRB-
cord-015021-pol2qm74	6541	8	for	for	IN
cord-015021-pol2qm74	6541	9	perisurgical	perisurgical	JJ
cord-015021-pol2qm74	6541	10	medication	medication	NN
cord-015021-pol2qm74	6541	11	and/or	and/or	CC
cord-015021-pol2qm74	6541	12	for	for	IN
cord-015021-pol2qm74	6541	13	treatment	treatment	NN
cord-015021-pol2qm74	6541	14	of	of	IN
cord-015021-pol2qm74	6541	15	trauma	trauma	NN
cord-015021-pol2qm74	6541	16	-	-	HYPH
cord-015021-pol2qm74	6541	17	induced	induce	VBN
cord-015021-pol2qm74	6541	18	temporary	temporary	JJ
cord-015021-pol2qm74	6541	19	immune	immune	JJ
cord-015021-pol2qm74	6541	20	depression	depression	NN
cord-015021-pol2qm74	6541	21	has	have	VBZ
cord-015021-pol2qm74	6541	22	been	be	VBN
cord-015021-pol2qm74	6541	23	strongly	strongly	RB
cord-015021-pol2qm74	6541	24	supported	support	VBN
cord-015021-pol2qm74	6541	25	also	also	RB
cord-015021-pol2qm74	6541	26	by	by	IN
cord-015021-pol2qm74	6541	27	targeted	target	VBN
cord-015021-pol2qm74	6541	28	animal	animal	NN
cord-015021-pol2qm74	6541	29	experiments	experiment	NNS
cord-015021-pol2qm74	6541	30	.	.	.
cord-015021-pol2qm74	6542	1	Thus	thus	RB
cord-015021-pol2qm74	6542	2	,	,	,
cord-015021-pol2qm74	6542	3	mortality	mortality	NN
cord-015021-pol2qm74	6542	4	of	of	IN
cord-015021-pol2qm74	6542	5	about	about	RB
cord-015021-pol2qm74	6542	6	90	90	CD
cord-015021-pol2qm74	6542	7	%	%	NN
cord-015021-pol2qm74	6542	8	registered	register	VBN
cord-015021-pol2qm74	6542	9	in	in	IN
cord-015021-pol2qm74	6542	10	mice	mouse	NNS
cord-015021-pol2qm74	6542	11	infected	infect	VBN
cord-015021-pol2qm74	6542	12	with	with	IN
cord-015021-pol2qm74	6542	13	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	6542	14	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	6542	15	after	after	IN
cord-015021-pol2qm74	6542	16	bum	bum	NN
cord-015021-pol2qm74	6542	17	injury	injury	NN
cord-015021-pol2qm74	6542	18	could	could	MD
cord-015021-pol2qm74	6542	19	be	be	VB
cord-015021-pol2qm74	6542	20	reduced	reduce	VBN
cord-015021-pol2qm74	6542	21	with	with	IN
cord-015021-pol2qm74	6542	22	the	the	DT
cord-015021-pol2qm74	6542	23	tetrapeptide	tetrapeptide	NN
cord-015021-pol2qm74	6542	24	treatment	treatment	NN
cord-015021-pol2qm74	6542	25	to	to	IN
cord-015021-pol2qm74	6542	26	a	a	DT
cord-015021-pol2qm74	6542	27	level	level	NN
cord-015021-pol2qm74	6542	28	which	which	WDT
cord-015021-pol2qm74	6542	29	did	do	VBD
cord-015021-pol2qm74	6542	30	not	not	RB
cord-015021-pol2qm74	6542	31	differ	differ	VB
cord-015021-pol2qm74	6542	32	significantly	significantly	RB
cord-015021-pol2qm74	6542	33	from	from	IN
cord-015021-pol2qm74	6542	34	that	that	DT
cord-015021-pol2qm74	6542	35	of	of	IN
cord-015021-pol2qm74	6542	36	the	the	DT
cord-015021-pol2qm74	6542	37	infected	infect	VBN
cord-015021-pol2qm74	6542	38	non	non	JJ
cord-015021-pol2qm74	6542	39	-	-	JJ
cord-015021-pol2qm74	6542	40	burned	burn	VBN
cord-015021-pol2qm74	6542	41	controls	control	NNS
cord-015021-pol2qm74	6542	42	.	.	.
cord-015021-pol2qm74	6543	1	Moreover	moreover	RB
cord-015021-pol2qm74	6543	2	,	,	,
cord-015021-pol2qm74	6543	3	observations	observation	NNS
cord-015021-pol2qm74	6543	4	gathered	gather	VBD
cord-015021-pol2qm74	6543	5	first	first	RB
cord-015021-pol2qm74	6543	6	of	of	IN
cord-015021-pol2qm74	6543	7	all	all	DT
cord-015021-pol2qm74	6543	8	with	with	IN
cord-015021-pol2qm74	6543	9	the	the	DT
cord-015021-pol2qm74	6543	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6543	11	model	model	NN
cord-015021-pol2qm74	6543	12	of	of	IN
cord-015021-pol2qm74	6543	13	air	air	NN
cord-015021-pol2qm74	6543	14	poach	poach	NNP
cord-015021-pol2qm74	6543	15	/	/	SYM
cord-015021-pol2qm74	6543	16	croton	croton	NNP
cord-015021-pol2qm74	6543	17	oil	oil	NN
cord-015021-pol2qm74	6543	18	grenuloma	grenuloma	NN
cord-015021-pol2qm74	6543	19	(	(	-LRB-
cord-015021-pol2qm74	6543	20	SELYE	SELYE	NNP
cord-015021-pol2qm74	6543	21	)	)	-RRB-
cord-015021-pol2qm74	6543	22	clearly	clearly	RB
cord-015021-pol2qm74	6543	23	showed	show	VBD
cord-015021-pol2qm74	6543	24	,	,	,
cord-015021-pol2qm74	6543	25	that	that	IN
cord-015021-pol2qm74	6543	26	a	a	DT
cord-015021-pol2qm74	6543	27	very	very	RB
cord-015021-pol2qm74	6543	28	definite	definite	JJ
cord-015021-pol2qm74	6543	29	,	,	,
cord-015021-pol2qm74	6543	30	antiexudative	antiexudative	JJ
cord-015021-pol2qm74	6543	31	effect	effect	NN
cord-015021-pol2qm74	6543	32	can	can	MD
cord-015021-pol2qm74	6543	33	be	be	VB
cord-015021-pol2qm74	6543	34	achieved	achieve	VBN
cord-015021-pol2qm74	6543	35	with	with	IN
cord-015021-pol2qm74	6543	36	this	this	DT
cord-015021-pol2qm74	6543	37	thymic	thymic	JJ
cord-015021-pol2qm74	6543	38	peptide	peptide	NN
cord-015021-pol2qm74	6543	39	.	.	.
cord-015021-pol2qm74	6544	1	As	as	IN
cord-015021-pol2qm74	6544	2	to	to	IN
cord-015021-pol2qm74	6544	3	this	this	DT
cord-015021-pol2qm74	6544	4	effect	effect	NN
cord-015021-pol2qm74	6544	5	,	,	,
cord-015021-pol2qm74	6544	6	thymocartin	thymocartin	NNP
cord-015021-pol2qm74	6544	7	has	have	VBZ
cord-015021-pol2qm74	6544	8	been	be	VBN
cord-015021-pol2qm74	6544	9	confirmed	confirm	VBN
cord-015021-pol2qm74	6544	10	,	,	,
cord-015021-pol2qm74	6544	11	e.g.	e.g.	RB
cord-015021-pol2qm74	6544	12	,	,	,
cord-015021-pol2qm74	6544	13	to	to	TO
cord-015021-pol2qm74	6544	14	be	be	VB
cord-015021-pol2qm74	6544	15	equipotent	equipotent	JJ
cord-015021-pol2qm74	6544	16	with	with	IN
cord-015021-pol2qm74	6544	17	locally	locally	RB
cord-015021-pol2qm74	6544	18	administered	administer	VBN
cord-015021-pol2qm74	6544	19	fluocinolone	fluocinolone	NN
cord-015021-pol2qm74	6544	20	acetonide	acetonide	NN
cord-015021-pol2qm74	6544	21	and/or	and/or	CC
cord-015021-pol2qm74	6545	1	s.c	s.c	NNP
cord-015021-pol2qm74	6545	2	.	.	NNP
cord-015021-pol2qm74	6545	3	injected	inject	VBD
cord-015021-pol2qm74	6545	4	prednisolone	prednisolone	NN
cord-015021-pol2qm74	6545	5	.	.	.
cord-015021-pol2qm74	6546	1	The	the	DT
cord-015021-pol2qm74	6546	2	interim	interim	JJ
cord-015021-pol2qm74	6546	3	results	result	NNS
cord-015021-pol2qm74	6546	4	of	of	IN
cord-015021-pol2qm74	6546	5	two	two	CD
cord-015021-pol2qm74	6546	6	explorative	explorative	JJ
cord-015021-pol2qm74	6546	7	double	double	JJ
cord-015021-pol2qm74	6546	8	-	-	HYPH
cord-015021-pol2qm74	6546	9	blind	blind	JJ
cord-015021-pol2qm74	6546	10	clinical	clinical	JJ
cord-015021-pol2qm74	6546	11	studies	study	NNS
cord-015021-pol2qm74	6546	12	(	(	-LRB-
cord-015021-pol2qm74	6546	13	involving	involve	VBG
cord-015021-pol2qm74	6546	14	more	more	JJR
cord-015021-pol2qm74	6546	15	than	than	IN
cord-015021-pol2qm74	6546	16	260	260	CD
cord-015021-pol2qm74	6546	17	patients	patient	NNS
cord-015021-pol2qm74	6546	18	after	after	IN
cord-015021-pol2qm74	6546	19	polytrauma	polytrauma	NN
cord-015021-pol2qm74	6546	20	and	and	CC
cord-015021-pol2qm74	6546	21	hip	hip	NN
cord-015021-pol2qm74	6546	22	-	-	HYPH
cord-015021-pol2qm74	6546	23	fracture	fracture	NN
cord-015021-pol2qm74	6546	24	untill	untill	NN
cord-015021-pol2qm74	6546	25	now	now	RB
cord-015021-pol2qm74	6546	26	,	,	,
cord-015021-pol2qm74	6546	27	respectively	respectively	RB
cord-015021-pol2qm74	6546	28	)	)	-RRB-
cord-015021-pol2qm74	6546	29	correspond	correspond	VBP
cord-015021-pol2qm74	6546	30	to	to	IN
cord-015021-pol2qm74	6546	31	the	the	DT
cord-015021-pol2qm74	6546	32	expectations	expectation	NNS
cord-015021-pol2qm74	6546	33	.	.	.
cord-015021-pol2qm74	6547	1	The	the	DT
cord-015021-pol2qm74	6547	2	treatment	treatment	NN
cord-015021-pol2qm74	6547	3	significantly	significantly	RB
cord-015021-pol2qm74	6547	4	reduced	reduce	VBD
cord-015021-pol2qm74	6547	5	the	the	DT
cord-015021-pol2qm74	6547	6	occurence	occurence	NN
cord-015021-pol2qm74	6547	7	of	of	IN
cord-015021-pol2qm74	6547	8	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	6547	9	infections	infection	NNS
cord-015021-pol2qm74	6547	10	,	,	,
cord-015021-pol2qm74	6547	11	the	the	DT
cord-015021-pol2qm74	6547	12	days	day	NNS
cord-015021-pol2qm74	6547	13	spend	spend	VBP
cord-015021-pol2qm74	6547	14	in	in	IN
cord-015021-pol2qm74	6547	15	intensive	intensive	JJ
cord-015021-pol2qm74	6547	16	care	care	NN
cord-015021-pol2qm74	6547	17	and	and	CC
cord-015021-pol2qm74	6547	18	on	on	IN
cord-015021-pol2qm74	6547	19	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6547	20	as	as	RB
cord-015021-pol2qm74	6547	21	well	well	RB
cord-015021-pol2qm74	6547	22	as	as	IN
cord-015021-pol2qm74	6547	23	it	-PRON-	PRP
cord-015021-pol2qm74	6547	24	shortened	shorten	VBD
cord-015021-pol2qm74	6547	25	the	the	DT
cord-015021-pol2qm74	6547	26	bed	bed	NN
cord-015021-pol2qm74	6547	27	-	-	HYPH
cord-015021-pol2qm74	6547	28	out	out	RP
cord-015021-pol2qm74	6547	29	time	time	NN
cord-015021-pol2qm74	6547	30	and	and	CC
cord-015021-pol2qm74	6547	31	reduced	reduce	VBD
cord-015021-pol2qm74	6547	32	the	the	DT
cord-015021-pol2qm74	6547	33	additional	additional	JJ
cord-015021-pol2qm74	6547	34	medication	medication	NN
cord-015021-pol2qm74	6547	35	.	.	.
cord-015021-pol2qm74	6548	1	Objective	objective	NN
cord-015021-pol2qm74	6548	2	of	of	IN
cord-015021-pol2qm74	6548	3	this	this	DT
cord-015021-pol2qm74	6548	4	prospective	prospective	JJ
cord-015021-pol2qm74	6548	5	randomized	randomized	JJ
cord-015021-pol2qm74	6548	6	study	study	NN
cord-015021-pol2qm74	6548	7	was	be	VBD
cord-015021-pol2qm74	6548	8	to	to	TO
cord-015021-pol2qm74	6548	9	further	further	RB
cord-015021-pol2qm74	6548	10	delineate	delineate	VB
cord-015021-pol2qm74	6548	11	the	the	DT
cord-015021-pol2qm74	6548	12	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6548	13	leading	lead	VBG
cord-015021-pol2qm74	6548	14	to	to	IN
cord-015021-pol2qm74	6548	15	these	these	DT
cord-015021-pol2qm74	6548	16	alterations	alteration	NNS
cord-015021-pol2qm74	6548	17	and	and	CC
cord-015021-pol2qm74	6548	18	to	to	TO
cord-015021-pol2qm74	6548	19	investigate	investigate	VB
cord-015021-pol2qm74	6548	20	the	the	DT
cord-015021-pol2qm74	6548	21	effects	effect	NNS
cord-015021-pol2qm74	6548	22	of	of	IN
cord-015021-pol2qm74	6548	23	immunomodulatory	immunomodulatory	JJ
cord-015021-pol2qm74	6548	24	intervention	intervention	NN
cord-015021-pol2qm74	6548	25	.	.	.
cord-015021-pol2qm74	6549	1	Patients	patient	NNS
cord-015021-pol2qm74	6549	2	and	and	CC
cord-015021-pol2qm74	6549	3	Methods	method	NNS
cord-015021-pol2qm74	6549	4	:	:	:
cord-015021-pol2qm74	6549	5	20	20	CD
cord-015021-pol2qm74	6549	6	patients	patient	NNS
cord-015021-pol2qm74	6549	7	(	(	-LRB-
cord-015021-pol2qm74	6549	8	pts	pts	NNP
cord-015021-pol2qm74	6549	9	)	)	-RRB-
cord-015021-pol2qm74	6549	10	formed	form	VBN
cord-015021-pol2qm74	6550	1	control	control	NNP
cord-015021-pol2qm74	6550	2	group	group	NNP
cord-015021-pol2qm74	6550	3	A.	A.	NNP
cord-015021-pol2qm74	6550	4	20	20	CD
cord-015021-pol2qm74	6550	5	group	group	NN
cord-015021-pol2qm74	6550	6	B	b	NN
cord-015021-pol2qm74	6550	7	pts	pts	NNP
cord-015021-pol2qm74	6550	8	received	receive	VBD
cord-015021-pol2qm74	6550	9	3x50	3x50	CD
cord-015021-pol2qm74	6550	10	mg	mg	NNP
cord-015021-pol2qm74	6550	11	Indomethacin	Indomethacin	NNP
cord-015021-pol2qm74	6550	12	(	(	-LRB-
cord-015021-pol2qm74	6550	13	Indo	Indo	NNP
cord-015021-pol2qm74	6550	14	)	)	-RRB-
cord-015021-pol2qm74	6550	15	from	from	IN
cord-015021-pol2qm74	6550	16	the	the	DT
cord-015021-pol2qm74	6550	17	first	first	JJ
cord-015021-pol2qm74	6550	18	(	(	-LRB-
cord-015021-pol2qm74	6550	19	dl	dl	NNP
cord-015021-pol2qm74	6550	20	)	)	-RRB-
cord-015021-pol2qm74	6550	21	to	to	IN
cord-015021-pol2qm74	6550	22	the	the	DT
cord-015021-pol2qm74	6550	23	fourth	fourth	JJ
cord-015021-pol2qm74	6550	24	postoperative	postoperative	JJ
cord-015021-pol2qm74	6550	25	day	day	NN
cord-015021-pol2qm74	6550	26	(	(	-LRB-
cord-015021-pol2qm74	6550	27	d5	d5	NNP
cord-015021-pol2qm74	6550	28	)	)	-RRB-
cord-015021-pol2qm74	6550	29	intravenously	intravenously	RB
cord-015021-pol2qm74	6550	30	to	to	TO
cord-015021-pol2qm74	6550	31	block	block	VB
cord-015021-pol2qm74	6550	32	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	6550	33	E2induced	e2induced	CD
cord-015021-pol2qm74	6550	34	suppression	suppression	NN
cord-015021-pol2qm74	6550	35	of	of	IN
cord-015021-pol2qm74	6550	36	CMI	CMI	NNP
cord-015021-pol2qm74	6550	37	response	response	NN
cord-015021-pol2qm74	6550	38	as	as	RB
cord-015021-pol2qm74	6550	39	well	well	RB
cord-015021-pol2qm74	6550	40	as	as	IN
cord-015021-pol2qm74	6551	1	50	50	CD
cord-015021-pol2qm74	6551	2	mg	mg	NNP
cord-015021-pol2qm74	6551	3	Thymopentin	Thymopentin	NNP
cord-015021-pol2qm74	6551	4	(	(	-LRB-
cord-015021-pol2qm74	6551	5	TP-5	TP-5	NNP
cord-015021-pol2qm74	6551	6	)	)	-RRB-
cord-015021-pol2qm74	6551	7	subcutaneously	subcutaneously	RB
cord-015021-pol2qm74	6551	8	preop	preop	NNP
cord-015021-pol2qm74	6551	9	.	.	NNP
cord-015021-pol2qm74	6551	10	,	,	,
cord-015021-pol2qm74	6551	11	on	on	IN
cord-015021-pol2qm74	6551	12	d2	d2	NN
cord-015021-pol2qm74	6551	13	and	and	CC
cord-015021-pol2qm74	6551	14	d4	d4	NN
cord-015021-pol2qm74	6551	15	to	to	TO
cord-015021-pol2qm74	6551	16	augment	augment	VB
cord-015021-pol2qm74	6551	17	CMI	CMI	NNP
cord-015021-pol2qm74	6551	18	reactivity	reactivity	NN
cord-015021-pol2qm74	6551	19	.	.	.
cord-015021-pol2qm74	6552	1	In	in	IN
cord-015021-pol2qm74	6552	2	vitro	vitro	FW
cord-015021-pol2qm74	6552	3	investigations	investigation	NNS
cord-015021-pol2qm74	6552	4	preoperatively	preoperatively	RB
cord-015021-pol2qm74	6552	5	,	,	,
cord-015021-pol2qm74	6552	6	on	on	IN
cord-015021-pol2qm74	6552	7	dl	dl	NNP
cord-015021-pol2qm74	6552	8	and	and	CC
cord-015021-pol2qm74	6552	9	d7	d7	NNP
cord-015021-pol2qm74	6552	10	included	include	VBD
cord-015021-pol2qm74	6552	11	measurements	measurement	NNS
cord-015021-pol2qm74	6552	12	of	of	IN
cord-015021-pol2qm74	6552	13	the	the	DT
cord-015021-pol2qm74	6552	14	percentage	percentage	NN
cord-015021-pol2qm74	6552	15	of	of	IN
cord-015021-pol2qm74	6552	16	CD4	CD4	NNP
cord-015021-pol2qm74	6552	17	+	+	CC
cord-015021-pol2qm74	6552	18	T	t	NN
cord-015021-pol2qm74	6552	19	-	-	HYPH
cord-015021-pol2qm74	6552	20	helper	helper	NN
cord-015021-pol2qm74	6552	21	(	(	-LRB-
cord-015021-pol2qm74	6552	22	TH	TH	NNP
cord-015021-pol2qm74	6552	23	)	)	-RRB-
cord-015021-pol2qm74	6552	24	cells	cell	NNS
cord-015021-pol2qm74	6552	25	,	,	,
cord-015021-pol2qm74	6552	26	pbytohemagglutinin	pbytohemagglutinin	JJ
cord-015021-pol2qm74	6552	27	(	(	-LRB-
cord-015021-pol2qm74	6552	28	PHA)induced	pha)induce	VBN
cord-015021-pol2qm74	6552	29	synthesis	synthesis	NN
cord-015021-pol2qm74	6552	30	of	of	IN
cord-015021-pol2qm74	6552	31	interleukin	interleukin	NN
cord-015021-pol2qm74	6552	32	(	(	-LRB-
cord-015021-pol2qm74	6552	33	IL)-2	il)-2	RB
cord-015021-pol2qm74	6552	34	as	as	IN
cord-015021-pol2qm74	6552	35	one	one	CD
cord-015021-pol2qm74	6552	36	cytokine	cytokine	NN
cord-015021-pol2qm74	6552	37	primarily	primarily	RB
cord-015021-pol2qm74	6552	38	produced	produce	VBN
cord-015021-pol2qm74	6552	39	by	by	IN
cord-015021-pol2qm74	6552	40	THl	THl	NNS
cord-015021-pol2qm74	6552	41	-	-	HYPH
cord-015021-pol2qm74	6552	42	cells	cell	NNS
cord-015021-pol2qm74	6552	43	,	,	,
cord-015021-pol2qm74	6552	44	and	and	CC
cord-015021-pol2qm74	6552	45	PHA	PHA	NNP
cord-015021-pol2qm74	6552	46	-	-	HYPH
cord-015021-pol2qm74	6552	47	induced	induce	VBN
cord-015021-pol2qm74	6552	48	synthesis	synthesis	NN
cord-015021-pol2qm74	6552	49	of	of	IN
cord-015021-pol2qm74	6552	50	IL-6	IL-6	NNP
cord-015021-pol2qm74	6552	51	as	as	IN
cord-015021-pol2qm74	6552	52	one	one	CD
cord-015021-pol2qm74	6552	53	cytokine	cytokine	NN
cord-015021-pol2qm74	6552	54	primarily	primarily	RB
cord-015021-pol2qm74	6552	55	produced	produce	VBN
cord-015021-pol2qm74	6552	56	by	by	IN
cord-015021-pol2qm74	6552	57	TH2-cells	th2-cell	NNS
cord-015021-pol2qm74	6552	58	.	.	.
cord-015021-pol2qm74	6553	1	Delayed	delay	VBN
cord-015021-pol2qm74	6553	2	type	type	NN
cord-015021-pol2qm74	6553	3	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	6553	4	(	(	-LRB-
cord-015021-pol2qm74	6553	5	DTH	DTH	NNP
cord-015021-pol2qm74	6553	6	)	)	-RRB-
cord-015021-pol2qm74	6553	7	skin	skin	NN
cord-015021-pol2qm74	6553	8	response	response	NN
cord-015021-pol2qm74	6553	9	to	to	IN
cord-015021-pol2qm74	6553	10	an	an	DT
cord-015021-pol2qm74	6553	11	antigen	antigen	NN
cord-015021-pol2qm74	6553	12	skin	skin	NN
cord-015021-pol2qm74	6553	13	test	test	NN
cord-015021-pol2qm74	6553	14	battery	battery	NN
cord-015021-pol2qm74	6553	15	and	and	CC
cord-015021-pol2qm74	6553	16	specific	specific	JJ
cord-015021-pol2qm74	6553	17	antibody	antibody	NN
cord-015021-pol2qm74	6553	18	(	(	-LRB-
cord-015021-pol2qm74	6553	19	AB	ab	NN
cord-015021-pol2qm74	6553	20	)	)	-RRB-
cord-015021-pol2qm74	6553	21	production	production	NN
cord-015021-pol2qm74	6553	22	following	follow	VBG
cord-015021-pol2qm74	6553	23	tetanus	tetanus	JJ
cord-015021-pol2qm74	6553	24	vaccination	vaccination	NN
cord-015021-pol2qm74	6553	25	preoperatively	preoperatively	NN
cord-015021-pol2qm74	6553	26	and	and	CC
cord-015021-pol2qm74	6553	27	on	on	IN
cord-015021-pol2qm74	6553	28	d7	d7	NNP
cord-015021-pol2qm74	6553	29	were	be	VBD
cord-015021-pol2qm74	6553	30	used	use	VBN
cord-015021-pol2qm74	6553	31	as	as	IN
cord-015021-pol2qm74	6553	32	in	in	IN
cord-015021-pol2qm74	6553	33	vivo	vivo	NN
cord-015021-pol2qm74	6553	34	tests	test	NNS
cord-015021-pol2qm74	6553	35	for	for	IN
cord-015021-pol2qm74	6553	36	THl	THl	NNP
cord-015021-pol2qm74	6553	37	-	-	:
cord-015021-pol2qm74	6553	38	and	and	CC
cord-015021-pol2qm74	6553	39	TH2-induced	TH2-induced	NNP
cord-015021-pol2qm74	6553	40	immune	immune	JJ
cord-015021-pol2qm74	6553	41	response	response	NN
cord-015021-pol2qm74	6553	42	respectively	respectively	RB
cord-015021-pol2qm74	6553	43	.	.	.
cord-015021-pol2qm74	6554	1	Results	result	NNS
cord-015021-pol2qm74	6554	2	:	:	:
cord-015021-pol2qm74	6555	1	Postoperatively	postoperatively	RB
cord-015021-pol2qm74	6555	2	,	,	,
cord-015021-pol2qm74	6555	3	group	group	NN
cord-015021-pol2qm74	6555	4	A	a	DT
cord-015021-pol2qm74	6555	5	pts	pts	NN
cord-015021-pol2qm74	6555	6	showed	show	VBD
cord-015021-pol2qm74	6555	7	a	a	DT
cord-015021-pol2qm74	6555	8	persistent	persistent	JJ
cord-015021-pol2qm74	6555	9	significant	significant	JJ
cord-015021-pol2qm74	6555	10	reduction	reduction	NN
cord-015021-pol2qm74	6555	11	of	of	IN
cord-015021-pol2qm74	6555	12	CD4	CD4	NNP
cord-015021-pol2qm74	6555	13	+	+	CC
cord-015021-pol2qm74	6555	14	TH	TH	NNP
cord-015021-pol2qm74	6555	15	cells	cell	NNS
cord-015021-pol2qm74	6555	16	,	,	,
cord-015021-pol2qm74	6555	17	IL-2	IL-2	NNP
cord-015021-pol2qm74	6555	18	/	/	SYM
cord-015021-pol2qm74	6555	19	IL-6	IL-6	NNP
cord-015021-pol2qm74	6555	20	ratio	ratio	NN
cord-015021-pol2qm74	6555	21	,	,	,
cord-015021-pol2qm74	6555	22	and	and	CC
cord-015021-pol2qm74	6555	23	DTH	DTH	NNP
cord-015021-pol2qm74	6555	24	skin	skin	NN
cord-015021-pol2qm74	6555	25	response	response	NN
cord-015021-pol2qm74	6555	26	as	as	IN
cord-015021-pol2qm74	6555	27	compared	compare	VBN
cord-015021-pol2qm74	6555	28	to	to	IN
cord-015021-pol2qm74	6555	29	baseline	baseline	JJ
cord-015021-pol2qm74	6555	30	values	value	NNS
cord-015021-pol2qm74	6555	31	(	(	-LRB-
cord-015021-pol2qm74	6555	32	BL	BL	NNP
cord-015021-pol2qm74	6555	33	)	)	-RRB-
cord-015021-pol2qm74	6555	34	,	,	,
cord-015021-pol2qm74	6555	35	while	while	IN
cord-015021-pol2qm74	6555	36	AB	AB	NNP
cord-015021-pol2qm74	6555	37	production	production	NN
cord-015021-pol2qm74	6555	38	increased	increase	VBD
cord-015021-pol2qm74	6555	39	(	(	-LRB-
cord-015021-pol2qm74	6555	40	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6555	41	vs	vs	IN
cord-015021-pol2qm74	6555	42	.	.	.
cord-015021-pol2qm74	6555	43	BL	BL	NNP
cord-015021-pol2qm74	6555	44	)	)	-RRB-
cord-015021-pol2qm74	6555	45	.	.	.
cord-015021-pol2qm74	6556	1	In	in	IN
cord-015021-pol2qm74	6556	2	group	group	NN
cord-015021-pol2qm74	6556	3	B	b	NN
cord-015021-pol2qm74	6556	4	pts	pts	NN
cord-015021-pol2qm74	6556	5	no	no	DT
cord-015021-pol2qm74	6556	6	change	change	NN
cord-015021-pol2qm74	6556	7	in	in	IN
cord-015021-pol2qm74	6556	8	CD4	CD4	NNP
cord-015021-pol2qm74	6556	9	+	+	CC
cord-015021-pol2qm74	6556	10	TH	TH	NNP
cord-015021-pol2qm74	6556	11	cells	cell	NNS
cord-015021-pol2qm74	6556	12	,	,	,
cord-015021-pol2qm74	6557	1	IL-2	IL-2	NNP
cord-015021-pol2qm74	6557	2	/	/	SYM
cord-015021-pol2qm74	6557	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	6557	4	ratio	ratio	NN
cord-015021-pol2qm74	6557	5	,	,	,
cord-015021-pol2qm74	6557	6	or	or	CC
cord-015021-pol2qm74	6557	7	DTH	DTH	NNP
cord-015021-pol2qm74	6557	8	skin	skin	NN
cord-015021-pol2qm74	6557	9	response	response	NN
cord-015021-pol2qm74	6557	10	was	be	VBD
cord-015021-pol2qm74	6557	11	observed	observe	VBN
cord-015021-pol2qm74	6557	12	(	(	-LRB-
cord-015021-pol2qm74	6557	13	p<0.05	p<0.05	JJ
cord-015021-pol2qm74	6557	14	vs.group	vs.group	NNP
cord-015021-pol2qm74	6557	15	A	A	NNP
cord-015021-pol2qm74	6557	16	)	)	-RRB-
cord-015021-pol2qm74	6557	17	,	,	,
cord-015021-pol2qm74	6557	18	and	and	CC
cord-015021-pol2qm74	6557	19	postoperative	postoperative	JJ
cord-015021-pol2qm74	6557	20	AB	ab	NN
cord-015021-pol2qm74	6557	21	production	production	NN
cord-015021-pol2qm74	6557	22	increased	increase	VBD
cord-015021-pol2qm74	6557	23	significantly	significantly	RB
cord-015021-pol2qm74	6557	24	(	(	-LRB-
cord-015021-pol2qm74	6557	25	n.s	n.s	NNP
cord-015021-pol2qm74	6557	26	.	.	NNP
cord-015021-pol2qm74	6557	27	vs.	vs.	CC
cord-015021-pol2qm74	6557	28	group	group	NNP
cord-015021-pol2qm74	6557	29	A	A	NNP
cord-015021-pol2qm74	6557	30	)	)	-RRB-
cord-015021-pol2qm74	6557	31	.	.	.
cord-015021-pol2qm74	6558	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	6558	2	:	:	:
cord-015021-pol2qm74	6559	1	1.These	1.these	CD
cord-015021-pol2qm74	6559	2	results	result	NNS
cord-015021-pol2qm74	6559	3	clearly	clearly	RB
cord-015021-pol2qm74	6559	4	indicate	indicate	VBP
cord-015021-pol2qm74	6559	5	a	a	DT
cord-015021-pol2qm74	6559	6	significant	significant	JJ
cord-015021-pol2qm74	6559	7	suppression	suppression	NN
cord-015021-pol2qm74	6559	8	of	of	IN
cord-015021-pol2qm74	6559	9	TH1	TH1	NNP
cord-015021-pol2qm74	6559	10	induced	induce	VBN
cord-015021-pol2qm74	6559	11	CMI	CMI	NNP
cord-015021-pol2qm74	6559	12	response	response	NN
cord-015021-pol2qm74	6559	13	,	,	,
cord-015021-pol2qm74	6559	14	while	while	IN
cord-015021-pol2qm74	6559	15	TH2	TH2	NNP
cord-015021-pol2qm74	6559	16	induced	induce	VBD
cord-015021-pol2qm74	6559	17	response	response	NN
cord-015021-pol2qm74	6559	18	remains	remain	VBZ
cord-015021-pol2qm74	6559	19	normal	normal	JJ
cord-015021-pol2qm74	6559	20	following	follow	VBG
cord-015021-pol2qm74	6559	21	OHS	OHS	NNP
cord-015021-pol2qm74	6559	22	.	.	.
cord-015021-pol2qm74	6560	1	2.These	2.these	CD
cord-015021-pol2qm74	6560	2	alterations	alteration	NNS
cord-015021-pol2qm74	6560	3	may	may	MD
cord-015021-pol2qm74	6560	4	gain	gain	VB
cord-015021-pol2qm74	6560	5	clinical	clinical	JJ
cord-015021-pol2qm74	6560	6	significance	significance	NN
cord-015021-pol2qm74	6560	7	whenever	whenever	WRB
cord-015021-pol2qm74	6560	8	a	a	DT
cord-015021-pol2qm74	6560	9	postoperative	postoperative	JJ
cord-015021-pol2qm74	6560	10	infection	infection	NN
cord-015021-pol2qm74	6560	11	requires	require	VBZ
cord-015021-pol2qm74	6560	12	a	a	DT
cord-015021-pol2qm74	6560	13	TH1	TH1	NNP
cord-015021-pol2qm74	6560	14	response	response	NN
cord-015021-pol2qm74	6560	15	and	and	CC
cord-015021-pol2qm74	6560	16	may	may	MD
cord-015021-pol2qm74	6560	17	explain	explain	VB
cord-015021-pol2qm74	6560	18	the	the	DT
cord-015021-pol2qm74	6560	19	susceptibility	susceptibility	NN
cord-015021-pol2qm74	6560	20	to	to	IN
cord-015021-pol2qm74	6560	21	opportunistic	opportunistic	JJ
cord-015021-pol2qm74	6560	22	microorganisms	microorganism	NNS
cord-015021-pol2qm74	6560	23	observed	observe	VBN
cord-015021-pol2qm74	6560	24	in	in	IN
cord-015021-pol2qm74	6560	25	pts	pts	NN
cord-015021-pol2qm74	6560	26	after	after	IN
cord-015021-pol2qm74	6560	27	OHS	OHS	NNP
cord-015021-pol2qm74	6560	28	.	.	.
cord-015021-pol2qm74	6561	1	3	3	LS
cord-015021-pol2qm74	6562	1	The	the	DT
cord-015021-pol2qm74	6562	2	aim	aim	NN
cord-015021-pol2qm74	6562	3	of	of	IN
cord-015021-pol2qm74	6562	4	this	this	DT
cord-015021-pol2qm74	6562	5	study	study	NN
cord-015021-pol2qm74	6562	6	was	be	VBD
cord-015021-pol2qm74	6562	7	to	to	TO
cord-015021-pol2qm74	6562	8	find	find	VB
cord-015021-pol2qm74	6562	9	out	out	RP
cord-015021-pol2qm74	6562	10	whether	whether	IN
cord-015021-pol2qm74	6562	11	the	the	DT
cord-015021-pol2qm74	6562	12	establishment	establishment	NN
cord-015021-pol2qm74	6562	13	of	of	IN
cord-015021-pol2qm74	6562	14	administration	administration	NN
cord-015021-pol2qm74	6562	15	of	of	IN
cord-015021-pol2qm74	6562	16	Thymostimulin	Thymostimulin	NNP
cord-015021-pol2qm74	6562	17	(	(	-LRB-
cord-015021-pol2qm74	6562	18	TP	tp	NN
cord-015021-pol2qm74	6562	19	-	-	HYPH
cord-015021-pol2qm74	6562	20	I	I	NNP
cord-015021-pol2qm74	6562	21	)	)	-RRB-
cord-015021-pol2qm74	6562	22	in	in	IN
cord-015021-pol2qm74	6562	23	jaundiced	jaundiced	JJ
cord-015021-pol2qm74	6562	24	and	and	CC
cord-015021-pol2qm74	6562	25	anergic	anergic	JJ
cord-015021-pol2qm74	6562	26	rats	rat	NNS
cord-015021-pol2qm74	6562	27	would	would	MD
cord-015021-pol2qm74	6562	28	return	return	VB
cord-015021-pol2qm74	6562	29	the	the	DT
cord-015021-pol2qm74	6562	30	rats	rat	NNS
cord-015021-pol2qm74	6562	31	to	to	IN
cord-015021-pol2qm74	6562	32	the	the	DT
cord-015021-pol2qm74	6562	33	state	state	NN
cord-015021-pol2qm74	6562	34	of	of	IN
cord-015021-pol2qm74	6562	35	immunocompetence	immunocompetence	NN
cord-015021-pol2qm74	6562	36	.	.	.
cord-015021-pol2qm74	6563	1	Material	material	NN
cord-015021-pol2qm74	6563	2	and	and	CC
cord-015021-pol2qm74	6563	3	Methods	method	NNS
cord-015021-pol2qm74	6563	4	.	.	.
cord-015021-pol2qm74	6564	1	Male	male	JJ
cord-015021-pol2qm74	6564	2	Wistar	Wistar	NNP
cord-015021-pol2qm74	6564	3	rats	rat	NNS
cord-015021-pol2qm74	6564	4	weighing	weigh	VBG
cord-015021-pol2qm74	6564	5	250	250	CD
cord-015021-pol2qm74	6564	6	-	-	SYM
cord-015021-pol2qm74	6564	7	300	300	CD
cord-015021-pol2qm74	6564	8	g	g	NN
cord-015021-pol2qm74	6564	9	were	be	VBD
cord-015021-pol2qm74	6564	10	injected	inject	VBN
cord-015021-pol2qm74	6564	11	with	with	IN
cord-015021-pol2qm74	6564	12	haemocyanin	haemocyanin	NNP
cord-015021-pol2qm74	6564	13	(	(	-LRB-
cord-015021-pol2qm74	6564	14	KLH	KLH	NNP
cord-015021-pol2qm74	6564	15	)	)	-RRB-
cord-015021-pol2qm74	6564	16	.	.	.
cord-015021-pol2qm74	6565	1	All	all	DT
cord-015021-pol2qm74	6565	2	rats	rat	NNS
cord-015021-pol2qm74	6565	3	with	with	IN
cord-015021-pol2qm74	6565	4	a	a	DT
cord-015021-pol2qm74	6565	5	positive	positive	JJ
cord-015021-pol2qm74	6565	6	response	response	NN
cord-015021-pol2qm74	6565	7	were	be	VBD
cord-015021-pol2qm74	6565	8	included	include	VBN
cord-015021-pol2qm74	6565	9	in	in	IN
cord-015021-pol2qm74	6565	10	the	the	DT
cord-015021-pol2qm74	6565	11	study	study	NN
cord-015021-pol2qm74	6565	12	and	and	CC
cord-015021-pol2qm74	6565	13	we	-PRON-	PRP
cord-015021-pol2qm74	6565	14	evalu	evalu	VBP
cord-015021-pol2qm74	6565	15	ated	ate	VBD
cord-015021-pol2qm74	6565	16	the	the	DT
cord-015021-pol2qm74	6565	17	T	T	NNP
cord-015021-pol2qm74	6565	18	cell	cell	NN
cord-015021-pol2qm74	6565	19	subpopulations	subpopulation	NNS
cord-015021-pol2qm74	6565	20	and	and	CC
cord-015021-pol2qm74	6565	21	IL-2	il-2	NN
cord-015021-pol2qm74	6565	22	.	.	.
cord-015021-pol2qm74	6566	1	They	-PRON-	PRP
cord-015021-pol2qm74	6566	2	underwent	undergo	VBD
cord-015021-pol2qm74	6566	3	laparotomy	laparotomy	NN
cord-015021-pol2qm74	6566	4	and	and	CC
cord-015021-pol2qm74	6566	5	the	the	DT
cord-015021-pol2qm74	6566	6	common	common	JJ
cord-015021-pol2qm74	6566	7	duct	duct	NN
cord-015021-pol2qm74	6566	8	was	be	VBD
cord-015021-pol2qm74	6566	9	ligated	ligate	VBN
cord-015021-pol2qm74	6566	10	and	and	CC
cord-015021-pol2qm74	6566	11	divided	divide	VBN
cord-015021-pol2qm74	6566	12	.	.	.
cord-015021-pol2qm74	6567	1	Those	those	DT
cord-015021-pol2qm74	6567	2	rats	rat	NNS
cord-015021-pol2qm74	6567	3	whic	whic	,
cord-015021-pol2qm74	6567	4	become	become	VBP
cord-015021-pol2qm74	6567	5	jaundiced	jaundiced	JJ
cord-015021-pol2qm74	6567	6	and	and	CC
cord-015021-pol2qm74	6567	7	anergic	anergic	JJ
cord-015021-pol2qm74	6567	8	one	one	CD
cord-015021-pol2qm74	6567	9	week	week	NN
cord-015021-pol2qm74	6567	10	after	after	IN
cord-015021-pol2qm74	6567	11	the	the	DT
cord-015021-pol2qm74	6567	12	operation	operation	NN
cord-015021-pol2qm74	6567	13	,	,	,
cord-015021-pol2qm74	6567	14	were	be	VBD
cord-015021-pol2qm74	6567	15	divided	divide	VBN
cord-015021-pol2qm74	6567	16	in	in	IN
cord-015021-pol2qm74	6567	17	two	two	CD
cord-015021-pol2qm74	6567	18	groups	group	NNS
cord-015021-pol2qm74	6567	19	:	:	:
cord-015021-pol2qm74	6567	20	control	control	NNP
cord-015021-pol2qm74	6567	21	group	group	NN
cord-015021-pol2qm74	6567	22	(	(	-LRB-
cord-015021-pol2qm74	6567	23	Objective	Objective	NNP
cord-015021-pol2qm74	6567	24	of	of	IN
cord-015021-pol2qm74	6567	25	study	study	NN
cord-015021-pol2qm74	6567	26	.	.	.
cord-015021-pol2qm74	6568	1	The	the	DT
cord-015021-pol2qm74	6568	2	goal	goal	NN
cord-015021-pol2qm74	6568	3	of	of	IN
cord-015021-pol2qm74	6568	4	this	this	DT
cord-015021-pol2qm74	6568	5	study	study	NN
cord-015021-pol2qm74	6568	6	was	be	VBD
cord-015021-pol2qm74	6568	7	to	to	TO
cord-015021-pol2qm74	6568	8	prove	prove	VB
cord-015021-pol2qm74	6568	9	the	the	DT
cord-015021-pol2qm74	6568	10	necessity	necessity	NN
cord-015021-pol2qm74	6568	11	of	of	IN
cord-015021-pol2qm74	6568	12	thymus	thymus	NN
cord-015021-pol2qm74	6568	13	derived	derive	VBN
cord-015021-pol2qm74	6568	14	immunomodulators	immunomodulator	NNS
cord-015021-pol2qm74	6568	15	treatment	treatment	NN
cord-015021-pol2qm74	6568	16	in	in	IN
cord-015021-pol2qm74	6568	17	acute	acute	JJ
cord-015021-pol2qm74	6568	18	period	period	NN
cord-015021-pol2qm74	6568	19	of	of	IN
cord-015021-pol2qm74	6568	20	infantine	infantine	NN
cord-015021-pol2qm74	6568	21	sepsis	sepsis	NN
cord-015021-pol2qm74	6568	22	,	,	,
cord-015021-pol2qm74	6568	23	Materials	material	NNS
cord-015021-pol2qm74	6568	24	and	and	CC
cord-015021-pol2qm74	6568	25	methods	method	NNS
cord-015021-pol2qm74	6568	26	.	.	.
cord-015021-pol2qm74	6569	1	Immune	immune	JJ
cord-015021-pol2qm74	6569	2	status	status	NN
cord-015021-pol2qm74	6569	3	was	be	VBD
cord-015021-pol2qm74	6569	4	investigated	investigate	VBN
cord-015021-pol2qm74	6569	5	in	in	IN
cord-015021-pol2qm74	6569	6	11O	11o	JJ
cord-015021-pol2qm74	6569	7	infants	infant	NNS
cord-015021-pol2qm74	6569	8	.	.	.
cord-015021-pol2qm74	6570	1	Clinical	clinical	JJ
cord-015021-pol2qm74	6570	2	conditions	condition	NNS
cord-015021-pol2qm74	6570	3	of	of	IN
cord-015021-pol2qm74	6570	4	children	child	NNS
cord-015021-pol2qm74	6570	5	were	be	VBD
cord-015021-pol2qm74	6570	6	defined	define	VBN
cord-015021-pol2qm74	6570	7	by	by	IN
cord-015021-pol2qm74	6570	8	syndrome	syndrome	NN
cord-015021-pol2qm74	6570	9	of	of	IN
cord-015021-pol2qm74	6570	10	multiple	multiple	JJ
cord-015021-pol2qm74	6570	11	polyorgan]c	polyorgan]c	NNP
cord-015021-pol2qm74	6570	12	insufficiency	insufficiency	NN
cord-015021-pol2qm74	6570	13	.	.	.
cord-015021-pol2qm74	6571	1	The	the	DT
cord-015021-pol2qm74	6571	2	heaviness	heaviness	NN
cord-015021-pol2qm74	6571	3	nf	nf	NN
cord-015021-pol2qm74	6571	4	condition	condition	NN
cord-015021-pol2qm74	6571	5	was	be	VBD
cord-015021-pol2qm74	6571	6	estimated	estimate	VBN
cord-015021-pol2qm74	6571	7	as	as	IN
cord-015021-pol2qm74	6571	8	the	the	DT
cord-015021-pol2qm74	6571	9	sum	sum	NN
cord-015021-pol2qm74	6571	10	of	of	IN
cord-015021-pol2qm74	6571	11	points	point	NNS
cord-015021-pol2qm74	6571	12	according	accord	VBG
cord-015021-pol2qm74	6571	13	to	to	IN
cord-015021-pol2qm74	6571	14	efforts	effort	NNS
cord-015021-pol2qm74	6571	15	needed	need	VBN
cord-015021-pol2qm74	6571	16	to	to	TO
cord-015021-pol2qm74	6571	17	restore	restore	VB
cord-015021-pol2qm74	6571	18	of	of	IN
cord-015021-pol2qm74	6571	19	basic	basic	JJ
cord-015021-pol2qm74	6571	20	living	living	NN
cord-015021-pol2qm74	6571	21	functions	function	NNS
cord-015021-pol2qm74	6571	22	-respiration	-respiration	NN
cord-015021-pol2qm74	6571	23	,	,	,
cord-015021-pol2qm74	6571	24	hemodynamJcs	hemodynamJcs	NNP
cord-015021-pol2qm74	6571	25	,	,	,
cord-015021-pol2qm74	6571	26	hemocoagulatlon	hemocoagulatlon	NNP
cord-015021-pol2qm74	6571	27	,	,	,
cord-015021-pol2qm74	6571	28	metabolism	metabolism	NN
cord-015021-pol2qm74	6571	29	,	,	,
cord-015021-pol2qm74	6571	30	functions	function	NNS
cord-015021-pol2qm74	6571	31	of	of	IN
cord-015021-pol2qm74	6571	32	liver	liver	NN
cord-015021-pol2qm74	6571	33	and	and	CC
cord-015021-pol2qm74	6571	34	kidneys	kidney	NNS
cord-015021-pol2qm74	6571	35	.	.	.
cord-015021-pol2qm74	6572	1	It	-PRON-	PRP
cord-015021-pol2qm74	6572	2	was	be	VBD
cord-015021-pol2qm74	6572	3	expressed	express	VBN
cord-015021-pol2qm74	6572	4	in	in	IN
cord-015021-pol2qm74	6572	5	form	form	NN
cord-015021-pol2qm74	6572	6	of	of	IN
cord-015021-pol2qm74	6572	7	clinic	clinic	NN
cord-015021-pol2qm74	6572	8	condition	condition	NN
cord-015021-pol2qm74	6572	9	classes	class	NNS
cord-015021-pol2qm74	6572	10	from	from	IN
cord-015021-pol2qm74	6572	11	1	1	CD
cord-015021-pol2qm74	6572	12	to	to	IN
cord-015021-pol2qm74	6572	13	4	4	CD
cord-015021-pol2qm74	6572	14	.	.	.
cord-015021-pol2qm74	6573	1	Results	result	NNS
cord-015021-pol2qm74	6573	2	.	.	.
cord-015021-pol2qm74	6574	1	It	-PRON-	PRP
cord-015021-pol2qm74	6574	2	was	be	VBD
cord-015021-pol2qm74	6574	3	found	find	VBN
cord-015021-pol2qm74	6574	4	that	that	IN
cord-015021-pol2qm74	6574	5	in	in	IN
cord-015021-pol2qm74	6574	6	100	100	CD
cord-015021-pol2qm74	6574	7	%	%	NN
cord-015021-pol2qm74	6574	8	of	of	IN
cord-015021-pol2qm74	6574	9	infants	infant	NNS
cord-015021-pol2qm74	6574	10	with	with	IN
cord-015021-pol2qm74	6574	11	3	3	CD
cord-015021-pol2qm74	6574	12	-	-	SYM
cord-015021-pol2qm74	6574	13	4	4	CD
cord-015021-pol2qm74	6574	14	classes	class	NNS
cord-015021-pol2qm74	6574	15	of	of	IN
cord-015021-pol2qm74	6574	16	heaviness	heaviness	NN
cord-015021-pol2qm74	6574	17	immunode[iciency	immunode[iciency	,
cord-015021-pol2qm74	6574	18	took	take	VBD
cord-015021-pol2qm74	6574	19	place	place	NN
cord-015021-pol2qm74	6574	20	simultaneously	simultaneously	RB
cord-015021-pol2qm74	6574	21	with	with	IN
cord-015021-pol2qm74	6574	22	II	II	NNP
cord-015021-pol2qm74	6574	23	and	and	CC
cord-015021-pol2qm74	6574	24	III	iii	CD
cord-015021-pol2qm74	6574	25	stages	stage	NNS
cord-015021-pol2qm74	6574	26	of	of	IN
cord-015021-pol2qm74	6574	27	hemocoagulattve	hemocoagulattve	NNP
cord-015021-pol2qm74	6574	28	syndrome	syndrome	NN
cord-015021-pol2qm74	6574	29	.	.	.
cord-015021-pol2qm74	6575	1	Amounts	amount	NNS
cord-015021-pol2qm74	6575	2	of	of	IN
cord-015021-pol2qm74	6575	3	T	t	NN
cord-015021-pol2qm74	6575	4	cells	cell	NNS
cord-015021-pol2qm74	6575	5	and	and	CC
cord-015021-pol2qm74	6575	6	T	t	NN
cord-015021-pol2qm74	6575	7	helpers	helper	NNS
cord-015021-pol2qm74	6575	8	were	be	VBD
cord-015021-pol2qm74	6575	9	decreased	decrease	VBN
cord-015021-pol2qm74	6575	10	more	more	JJR
cord-015021-pol2qm74	6575	11	then	then	RB
cord-015021-pol2qm74	6575	12	2	2	CD
cord-015021-pol2qm74	6575	13	times	time	NNS
cord-015021-pol2qm74	6575	14	,	,	,
cord-015021-pol2qm74	6575	15	ratio	ratio	NN
cord-015021-pol2qm74	6575	16	Th	Th	NNP
cord-015021-pol2qm74	6575	17	/	/	SYM
cord-015021-pol2qm74	6575	18	Ts	Ts	NNP
cord-015021-pol2qm74	6575	19	was	be	VBD
cord-015021-pol2qm74	6575	20	reduced	reduce	VBN
cord-015021-pol2qm74	6575	21	to	to	IN
cord-015021-pol2qm74	6575	22	1.5	1.5	CD
cord-015021-pol2qm74	6575	23	or	or	CC
cord-015021-pol2qm74	6575	24	lower	low	JJR
cord-015021-pol2qm74	6575	25	.	.	.
cord-015021-pol2qm74	6576	1	Concentration	concentration	NN
cord-015021-pol2qm74	6576	2	of	of	IN
cord-015021-pol2qm74	6576	3	lgG	lgG	NNP
cord-015021-pol2qm74	6576	4	and	and	CC
cord-015021-pol2qm74	6576	5	IgAwas	IgAwas	NNP
cord-015021-pol2qm74	6576	6	reduced	reduce	VBD
cord-015021-pol2qm74	6576	7	almost	almost	RB
cord-015021-pol2qm74	6576	8	a	a	DT
cord-015021-pol2qm74	6576	9	hull	hull	NN
cord-015021-pol2qm74	6576	10	in	in	IN
cord-015021-pol2qm74	6576	11	comparison	comparison	NN
cord-015021-pol2qm74	6576	12	to	to	TO
cord-015021-pol2qm74	6576	13	control	control	VB
cord-015021-pol2qm74	6576	14	.	.	.
cord-015021-pol2qm74	6577	1	Phagocytic	phagocytic	JJ
cord-015021-pol2qm74	6577	2	and	and	CC
cord-015021-pol2qm74	6577	3	metabolic	metabolic	JJ
cord-015021-pol2qm74	6577	4	activities	activity	NNS
cord-015021-pol2qm74	6578	1	nf	nf	NNP
cord-015021-pol2qm74	6578	2	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	6578	3	were	be	VBD
cord-015021-pol2qm74	6578	4	depressed	depressed	JJ
cord-015021-pol2qm74	6578	5	.	.	.
cord-015021-pol2qm74	6579	1	Complement	complement	JJ
cord-015021-pol2qm74	6579	2	system	system	NN
cord-015021-pol2qm74	6579	3	state	state	NN
cord-015021-pol2qm74	6579	4	was	be	VBD
cord-015021-pol2qm74	6579	5	changed	change	VBN
cord-015021-pol2qm74	6579	6	:	:	:
cord-015021-pol2qm74	6579	7	the	the	DT
cord-015021-pol2qm74	6579	8	functional	functional	JJ
cord-015021-pol2qm74	6579	9	activity	activity	NN
cord-015021-pol2qm74	6579	10	of	of	IN
cord-015021-pol2qm74	6579	11	the	the	DT
cord-015021-pol2qm74	6579	12	alternative	alternative	JJ
cord-015021-pol2qm74	6579	13	pathway	pathway	NN
cord-015021-pol2qm74	6579	14	factors	factor	NNS
cord-015021-pol2qm74	6579	15	B	b	NN
cord-015021-pol2qm74	6579	16	,	,	,
cord-015021-pol2qm74	6579	17	D	d	NN
cord-015021-pol2qm74	6579	18	and	and	CC
cord-015021-pol2qm74	6579	19	the	the	DT
cord-015021-pol2qm74	6579	20	level	level	NN
cord-015021-pol2qm74	6579	21	or	or	CC
cord-015021-pol2qm74	6579	22	C3a	C3a	NNP
cord-015021-pol2qm74	6579	23	subcomponent	subcomponent	NN
cord-015021-pol2qm74	6579	24	were	be	VBD
cord-015021-pol2qm74	6579	25	increased	increase	VBN
cord-015021-pol2qm74	6579	26	but	but	CC
cord-015021-pol2qm74	6579	27	the	the	DT
cord-015021-pol2qm74	6579	28	level	level	NN
cord-015021-pol2qm74	6579	29	of	of	IN
cord-015021-pol2qm74	6579	30	C2	C2	NNP
cord-015021-pol2qm74	6579	31	,	,	,
cord-015021-pol2qm74	6579	32	C3	C3	NNP
cord-015021-pol2qm74	6579	33	,	,	,
cord-015021-pol2qm74	6579	34	,	,	,
cord-015021-pol2qm74	6579	35	C4	C4	NNP
cord-015021-pol2qm74	6579	36	and	and	CC
cord-015021-pol2qm74	6579	37	C5	C5	NNP
cord-015021-pol2qm74	6579	38	components	component	NNS
cord-015021-pol2qm74	6579	39	of	of	IN
cord-015021-pol2qm74	6579	40	the	the	DT
cord-015021-pol2qm74	6579	41	classic	classic	JJ
cord-015021-pol2qm74	6579	42	pathway	pathway	NN
cord-015021-pol2qm74	6579	43	were	be	VBD
cord-015021-pol2qm74	6579	44	decreased	decrease	VBN
cord-015021-pol2qm74	6579	45	.	.	.
cord-015021-pol2qm74	6580	1	During	during	IN
cord-015021-pol2qm74	6580	2	the	the	DT
cord-015021-pol2qm74	6580	3	development	development	NN
cord-015021-pol2qm74	6580	4	of	of	IN
cord-015021-pol2qm74	6580	5	coagnlopathy	coagnlopathy	NNP
cord-015021-pol2qm74	6580	6	the	the	DT
cord-015021-pol2qm74	6580	7	direct	direct	JJ
cord-015021-pol2qm74	6580	8	correlation	correlation	NN
cord-015021-pol2qm74	6580	9	between	between	IN
cord-015021-pol2qm74	6580	10	CHSO	CHSO	NNS
cord-015021-pol2qm74	6580	11	,	,	,
cord-015021-pol2qm74	6580	12	levels	level	NNS
cord-015021-pol2qm74	6580	13	of	of	IN
cord-015021-pol2qm74	6580	14	plasminogen	plasminogen	NN
cord-015021-pol2qm74	6580	15	and	and	CC
cord-015021-pol2qm74	6580	16	antithrombine	antithrombine	NNP
cord-015021-pol2qm74	6580	17	III	III	NNP
cord-015021-pol2qm74	6580	18	was	be	VBD
cord-015021-pol2qm74	6580	19	found	find	VBN
cord-015021-pol2qm74	6580	20	.	.	.
cord-015021-pol2qm74	6581	1	In	in	IN
cord-015021-pol2qm74	6581	2	greater	great	JJR
cord-015021-pol2qm74	6581	3	extent	extent	NN
cord-015021-pol2qm74	6581	4	the	the	DT
cord-015021-pol2qm74	6581	5	function	function	NN
cord-015021-pol2qm74	6581	6	of	of	IN
cord-015021-pol2qm74	6581	7	immune	immune	JJ
cord-015021-pol2qm74	6581	8	system	system	NN
cord-015021-pol2qm74	6581	9	was	be	VBD
cord-015021-pol2qm74	6581	10	disodered	disodere	VBN
cord-015021-pol2qm74	6581	11	in	in	IN
cord-015021-pol2qm74	6581	12	accordance	accordance	NN
cord-015021-pol2qm74	6581	13	with	with	IN
cord-015021-pol2qm74	6581	14	2	2	CD
cord-015021-pol2qm74	6581	15	point	point	NN
cord-015021-pol2qm74	6581	16	metabolic	metabolic	JJ
cord-015021-pol2qm74	6581	17	violations	violation	NNS
cord-015021-pol2qm74	6581	18	and	and	CC
cord-015021-pol2qm74	6581	19	hemocoagulative	hemocoagulative	JJ
cord-015021-pol2qm74	6581	20	disturbances	disturbance	NNS
cord-015021-pol2qm74	6581	21	considered	consider	VBN
cord-015021-pol2qm74	6581	22	as	as	IN
cord-015021-pol2qm74	6581	23	disseminated	disseminate	VBN
cord-015021-pol2qm74	6581	24	inmtravaseular	inmtravaseular	JJ
cord-015021-pol2qm74	6581	25	clotting	clotting	NN
cord-015021-pol2qm74	6581	26	syndrome	syndrome	NN
cord-015021-pol2qm74	6581	27	on	on	IN
cord-015021-pol2qm74	6581	28	II	II	NNP
cord-015021-pol2qm74	6581	29	or	or	CC
cord-015021-pol2qm74	6581	30	IlI	ili	NN
cord-015021-pol2qm74	6581	31	stages	stage	NNS
cord-015021-pol2qm74	6581	32	.	.	.
cord-015021-pol2qm74	6582	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	6582	2	.	.	.
cord-015021-pol2qm74	6583	1	The	the	DT
cord-015021-pol2qm74	6583	2	rehabilitation	rehabilitation	NN
cord-015021-pol2qm74	6583	3	of	of	IN
cord-015021-pol2qm74	6583	4	the	the	DT
cord-015021-pol2qm74	6583	5	immune	immune	JJ
cord-015021-pol2qm74	6583	6	system	system	NN
cord-015021-pol2qm74	6583	7	functions	function	NNS
cord-015021-pol2qm74	6583	8	was	be	VBD
cord-015021-pol2qm74	6583	9	promoted	promote	VBN
cord-015021-pol2qm74	6583	10	by	by	IN
cord-015021-pol2qm74	6583	11	taetivine	taetivine	NNP
cord-015021-pol2qm74	6583	12	and	and	CC
cord-015021-pol2qm74	6583	13	thymaline	thymaline	NN
cord-015021-pol2qm74	6583	14	in	in	IN
cord-015021-pol2qm74	6583	15	doses	dose	NNS
cord-015021-pol2qm74	6583	16	of	of	IN
cord-015021-pol2qm74	6583	17	I-3	I-3	NNP
cord-015021-pol2qm74	6583	18	mcg	mcg	NNP
cord-015021-pol2qm74	6583	19	/	/	SYM
cord-015021-pol2qm74	6583	20	kg	kg	NNP
cord-015021-pol2qm74	6583	21	per	per	IN
cord-015021-pol2qm74	6583	22	day	day	NN
cord-015021-pol2qm74	6583	23	and	and	CC
cord-015021-pol2qm74	6583	24	2	2	CD
cord-015021-pol2qm74	6583	25	mg	mg	NNP
cord-015021-pol2qm74	6583	26	/	/	SYM
cord-015021-pol2qm74	6583	27	kg	kg	NN
cord-015021-pol2qm74	6583	28	per	per	IN
cord-015021-pol2qm74	6583	29	day	day	NN
cord-015021-pol2qm74	6583	30	accordingly	accordingly	RB
cord-015021-pol2qm74	6583	31	during	during	IN
cord-015021-pol2qm74	6583	32	a	a	DT
cord-015021-pol2qm74	6583	33	week	week	NN
cord-015021-pol2qm74	6583	34	in	in	IN
cord-015021-pol2qm74	6583	35	children	child	NNS
cord-015021-pol2qm74	6583	36	with	with	IN
cord-015021-pol2qm74	6583	37	3	3	CD
cord-015021-pol2qm74	6583	38	-4	-4	NNS
cord-015021-pol2qm74	6583	39	classes	class	NNS
cord-015021-pol2qm74	6583	40	el	el	NNP
cord-015021-pol2qm74	6583	41	heaviness	heaviness	NN
cord-015021-pol2qm74	6583	42	.	.	.
cord-015021-pol2qm74	6584	1	AIter	aiter	RB
cord-015021-pol2qm74	6584	2	11	11	CD
cord-015021-pol2qm74	6584	3	-	-	SYM
cord-015021-pol2qm74	6584	4	14	14	CD
cord-015021-pol2qm74	6584	5	days	day	NNS
cord-015021-pol2qm74	6584	6	tactivine	tactivine	NNP
cord-015021-pol2qm74	6584	7	had	have	VBD
cord-015021-pol2qm74	6584	8	advantage	advantage	NN
cord-015021-pol2qm74	6584	9	.	.	.
cord-015021-pol2qm74	6585	1	When	when	WRB
cord-015021-pol2qm74	6585	2	eoagulopathy	eoagulopathy	NNP
cord-015021-pol2qm74	6585	3	took	take	VBD
cord-015021-pol2qm74	6585	4	place	place	NN
cord-015021-pol2qm74	6585	5	thynaalJne	thynaalJne	NNS
cord-015021-pol2qm74	6585	6	promoted	promote	VBN
cord-015021-pol2qm74	6585	7	restoration	restoration	NN
cord-015021-pol2qm74	6585	8	of	of	IN
cord-015021-pol2qm74	6585	9	(	(	-LRB-
cord-015021-pol2qm74	6585	10	1	1	CD
cord-015021-pol2qm74	6585	11	-	-	HYPH
cord-015021-pol2qm74	6585	12	3)-~-D	3)-~-d	CD
cord-015021-pol2qm74	6585	13	-	-	HYPH
cord-015021-pol2qm74	6585	14	glucan	glucan	NN
cord-015021-pol2qm74	6585	15	(	(	-LRB-
cord-015021-pol2qm74	6585	16	BGC	BGC	NNP
cord-015021-pol2qm74	6585	17	)	)	-RRB-
cord-015021-pol2qm74	6585	18	is	be	VBZ
cord-015021-pol2qm74	6585	19	a	a	DT
cord-015021-pol2qm74	6585	20	major	major	JJ
cord-015021-pol2qm74	6585	21	cell	cell	NN
cord-015021-pol2qm74	6585	22	wall	wall	NN
cord-015021-pol2qm74	6585	23	compornent	compornent	NNP
cord-015021-pol2qm74	6585	24	of	of	IN
cord-015021-pol2qm74	6585	25	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	6585	26	fungi	fungus	NNS
cord-015021-pol2qm74	6585	27	and	and	CC
cord-015021-pol2qm74	6585	28	shows	show	VBZ
cord-015021-pol2qm74	6585	29	many	many	JJ
cord-015021-pol2qm74	6585	30	immunopharmacological	immunopharmacological	JJ
cord-015021-pol2qm74	6585	31	activities	activity	NNS
cord-015021-pol2qm74	6585	32	on	on	IN
cord-015021-pol2qm74	6585	33	experimental	experimental	JJ
cord-015021-pol2qm74	6585	34	animals	animal	NNS
cord-015021-pol2qm74	6585	35	.	.	.
cord-015021-pol2qm74	6586	1	LPS	LPS	NNP
cord-015021-pol2qm74	6586	2	is	be	VBZ
cord-015021-pol2qm74	6586	3	also	also	RB
cord-015021-pol2qm74	6586	4	derived	derive	VBN
cord-015021-pol2qm74	6586	5	from	from	IN
cord-015021-pol2qm74	6586	6	gram	gram	JJ
cord-015021-pol2qm74	6586	7	-	-	HYPH
cord-015021-pol2qm74	6586	8	negative	negative	JJ
cord-015021-pol2qm74	6586	9	bacteria	bacteria	NNS
cord-015021-pol2qm74	6586	10	and	and	CC
cord-015021-pol2qm74	6586	11	have	have	VBP
cord-015021-pol2qm74	6586	12	in	in	IN
cord-015021-pol2qm74	6586	13	~	~	NFP
cord-015021-pol2qm74	6586	14	ttnomodulating	ttnomodulating	NN
cord-015021-pol2qm74	6586	15	activities	activity	NNS
cord-015021-pol2qm74	6586	16	on	on	IN
cord-015021-pol2qm74	6586	17	immune	immune	JJ
cord-015021-pol2qm74	6586	18	systems	system	NNS
cord-015021-pol2qm74	6586	19	positively	positively	RB
cord-015021-pol2qm74	6586	20	or	or	CC
cord-015021-pol2qm74	6586	21	negatively	negatively	RB
cord-015021-pol2qm74	6586	22	.	.	.
cord-015021-pol2qm74	6587	1	Because	because	IN
cord-015021-pol2qm74	6587	2	of	of	IN
cord-015021-pol2qm74	6587	3	difficulty	difficulty	NN
cord-015021-pol2qm74	6587	4	to	to	TO
cord-015021-pol2qm74	6587	5	cure	cure	VB
cord-015021-pol2qm74	6587	6	contaminating	contaminate	VBG
cord-015021-pol2qm74	6587	7	LPS	lp	NNS
cord-015021-pol2qm74	6587	8	from	from	IN
cord-015021-pol2qm74	6587	9	BGC	BGC	NNP
cord-015021-pol2qm74	6587	10	preparations	preparation	NNS
cord-015021-pol2qm74	6587	11	,	,	,
cord-015021-pol2qm74	6587	12	it	-PRON-	PRP
cord-015021-pol2qm74	6587	13	is	be	VBZ
cord-015021-pol2qm74	6587	14	very	very	RB
cord-015021-pol2qm74	6587	15	hard	hard	JJ
cord-015021-pol2qm74	6587	16	to	to	TO
cord-015021-pol2qm74	6587	17	evaluate	evaluate	VB
cord-015021-pol2qm74	6587	18	the	the	DT
cord-015021-pol2qm74	6587	19	exact	exact	JJ
cord-015021-pol2qm74	6587	20	activities	activity	NNS
cord-015021-pol2qm74	6587	21	of	of	IN
cord-015021-pol2qm74	6587	22	BGC	BGC	NNP
cord-015021-pol2qm74	6587	23	.	.	.
cord-015021-pol2qm74	6588	1	In	in	IN
cord-015021-pol2qm74	6588	2	this	this	DT
cord-015021-pol2qm74	6588	3	study	study	NN
cord-015021-pol2qm74	6588	4	,	,	,
cord-015021-pol2qm74	6588	5	we	-PRON-	PRP
cord-015021-pol2qm74	6588	6	compared	compare	VBD
cord-015021-pol2qm74	6588	7	the	the	DT
cord-015021-pol2qm74	6588	8	immunological	immunological	JJ
cord-015021-pol2qm74	6588	9	activities	activity	NNS
cord-015021-pol2qm74	6588	10	of	of	IN
cord-015021-pol2qm74	6588	11	LPS	LPS	NNP
cord-015021-pol2qm74	6588	12	ans	an	NNS
cord-015021-pol2qm74	6588	13	highly	highly	RB
cord-015021-pol2qm74	6588	14	purified	purify	VBD
cord-015021-pol2qm74	6588	15	BGC	BGC	NNP
cord-015021-pol2qm74	6588	16	on	on	IN
cord-015021-pol2qm74	6588	17	murine	murine	JJ
cord-015021-pol2qm74	6588	18	system	system	NN
cord-015021-pol2qm74	6588	19	.	.	.
cord-015021-pol2qm74	6589	1	Materials	material	NNS
cord-015021-pol2qm74	6589	2	and	and	CC
cord-015021-pol2qm74	6589	3	Methods	method	NNS
cord-015021-pol2qm74	6589	4	:	:	:
cord-015021-pol2qm74	6589	5	C3H	C3H	NNP
cord-015021-pol2qm74	6589	6	/	/	SYM
cord-015021-pol2qm74	6589	7	HeN	HeN	NNS
cord-015021-pol2qm74	6589	8	or	or	CC
cord-015021-pol2qm74	6589	9	C3H	c3h	RB
cord-015021-pol2qm74	6589	10	/	/	SYM
cord-015021-pol2qm74	6589	11	HeJ	hej	NN
cord-015021-pol2qm74	6589	12	mice	mouse	NNS
cord-015021-pol2qm74	6589	13	,	,	,
cord-015021-pol2qm74	6589	14	6	6	CD
cord-015021-pol2qm74	6589	15	to	to	TO
cord-015021-pol2qm74	6589	16	12	12	CD
cord-015021-pol2qm74	6589	17	wkolds	wkold	NNS
cord-015021-pol2qm74	6589	18	of	of	IN
cord-015021-pol2qm74	6589	19	both	both	DT
cord-015021-pol2qm74	6589	20	sexes	sex	NNS
cord-015021-pol2qm74	6589	21	were	be	VBD
cord-015021-pol2qm74	6589	22	used	use	VBN
cord-015021-pol2qm74	6589	23	through	through	IN
cord-015021-pol2qm74	6589	24	experiments	experiment	NNS
cord-015021-pol2qm74	6589	25	.	.	.
cord-015021-pol2qm74	6590	1	Highly	highly	RB
cord-015021-pol2qm74	6590	2	purified	purify	VBN
cord-015021-pol2qm74	6590	3	(	(	-LRB-
cord-015021-pol2qm74	6590	4	1	1	CD
cord-015021-pol2qm74	6590	5	-	-	SYM
cord-015021-pol2qm74	6590	6	3	3	CD
cord-015021-pol2qm74	6590	7	)	)	-RRB-
cord-015021-pol2qm74	6590	8	-{5-D	-{5-D	HYPH
cord-015021-pol2qm74	6590	9	-	-	HYPH
cord-015021-pol2qm74	6590	10	glucan	glucan	JJ
cord-015021-pol2qm74	6590	11	(	(	-LRB-
cord-015021-pol2qm74	6590	12	Gurdran	Gurdran	NNP
cord-015021-pol2qm74	6590	13	;	;	:
cord-015021-pol2qm74	6590	14	BGC)was	BGC)was	NNP
cord-015021-pol2qm74	6590	15	courteous	courteous	JJ
cord-015021-pol2qm74	6590	16	gift	gift	NN
cord-015021-pol2qm74	6590	17	from	from	IN
cord-015021-pol2qm74	6591	1	Seikagaku	Seikagaku	NNP
cord-015021-pol2qm74	6591	2	Kogyo	Kogyo	NNP
cord-015021-pol2qm74	6591	3	Co.	Co.	NNP
cord-015021-pol2qm74	6591	4	Tokyo	Tokyo	NNP
cord-015021-pol2qm74	6591	5	,	,	,
cord-015021-pol2qm74	6591	6	Japan	Japan	NNP
cord-015021-pol2qm74	6591	7	and	and	CC
cord-015021-pol2qm74	6591	8	resolved	resolve	VBD
cord-015021-pol2qm74	6591	9	in	in	IN
cord-015021-pol2qm74	6591	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6591	11	-	-	HYPH
cord-015021-pol2qm74	6591	12	free	free	JJ
cord-015021-pol2qm74	6591	13	ultra	ultra	JJ
cord-015021-pol2qm74	6591	14	-	-	JJ
cord-015021-pol2qm74	6591	15	pure	pure	JJ
cord-015021-pol2qm74	6591	16	water	water	NN
cord-015021-pol2qm74	6591	17	.	.	.
cord-015021-pol2qm74	6592	1	Escherichia	escherichia	NN
cord-015021-pol2qm74	6592	2	cell	cell	NN
cord-015021-pol2qm74	6592	3	LPS	LPS	NNP
cord-015021-pol2qm74	6592	4	was	be	VBD
cord-015021-pol2qm74	6592	5	purchased	purchase	VBN
cord-015021-pol2qm74	6592	6	from	from	IN
cord-015021-pol2qm74	6592	7	Sigma	Sigma	NNP
cord-015021-pol2qm74	6592	8	Chemicals	Chemicals	NNP
cord-015021-pol2qm74	6592	9	,	,	,
cord-015021-pol2qm74	6592	10	USA	USA	NNP
cord-015021-pol2qm74	6592	11	.	.	.
cord-015021-pol2qm74	6593	1	Mitogenic	Mitogenic	NNP
cord-015021-pol2qm74	6593	2	activities	activity	NNS
cord-015021-pol2qm74	6593	3	of	of	IN
cord-015021-pol2qm74	6593	4	BGC	BGC	NNP
cord-015021-pol2qm74	6593	5	or	or	CC
cord-015021-pol2qm74	6593	6	LPS	LPS	NNP
cord-015021-pol2qm74	6593	7	on	on	IN
cord-015021-pol2qm74	6593	8	splenic	splenic	JJ
cord-015021-pol2qm74	6593	9	cells	cell	NNS
cord-015021-pol2qm74	6593	10	were	be	VBD
cord-015021-pol2qm74	6593	11	measured	measure	VBN
cord-015021-pol2qm74	6593	12	by	by	IN
cord-015021-pol2qm74	6593	13	MIT	MIT	NNP
cord-015021-pol2qm74	6593	14	dye	dye	NN
cord-015021-pol2qm74	6593	15	assay	assay	NN
cord-015021-pol2qm74	6593	16	.	.	.
cord-015021-pol2qm74	6594	1	In	in	IN
cord-015021-pol2qm74	6594	2	vitro	vitro	FW
cord-015021-pol2qm74	6594	3	activation	activation	NN
cord-015021-pol2qm74	6594	4	of	of	IN
cord-015021-pol2qm74	6594	5	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6594	6	exudate	exudate	NNP
cord-015021-pol2qm74	6594	7	macrophage	macrophage	NN
cord-015021-pol2qm74	6594	8	(	(	-LRB-
cord-015021-pol2qm74	6594	9	PEN	pen	NN
cord-015021-pol2qm74	6594	10	)	)	-RRB-
cord-015021-pol2qm74	6594	11	have	have	VBP
cord-015021-pol2qm74	6594	12	moniotored	moniotore	VBN
cord-015021-pol2qm74	6594	13	by	by	IN
cord-015021-pol2qm74	6594	14	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	6594	15	and	and	CC
cord-015021-pol2qm74	6594	16	intraphagocytic	intraphagocytic	JJ
cord-015021-pol2qm74	6594	17	killing	killing	NN
cord-015021-pol2qm74	6594	18	of	of	IN
cord-015021-pol2qm74	6594	19	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	6594	20	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	6594	21	(	(	-LRB-
cord-015021-pol2qm74	6594	22	Z	z	NN
cord-015021-pol2qm74	6594	23	~	~	NFP
cord-015021-pol2qm74	6594	24	B-139	b-139	NN
cord-015021-pol2qm74	6594	25	.	.	.
cord-015021-pol2qm74	6595	1	Induction	induction	NN
cord-015021-pol2qm74	6595	2	of	of	IN
cord-015021-pol2qm74	6595	3	cytokine	cytokine	NN
cord-015021-pol2qm74	6595	4	productions	production	NNS
cord-015021-pol2qm74	6595	5	from	from	IN
cord-015021-pol2qm74	6595	6	PEM	pem	NN
cord-015021-pol2qm74	6595	7	or	or	CC
cord-015021-pol2qm74	6595	8	spleen	spleen	NN
cord-015021-pol2qm74	6595	9	cells	cell	NNS
cord-015021-pol2qm74	6595	10	induced	induce	VBN
cord-015021-pol2qm74	6595	11	by	by	IN
cord-015021-pol2qm74	6595	12	BGC	BGC	NNP
cord-015021-pol2qm74	6595	13	or	or	CC
cord-015021-pol2qm74	6595	14	LPS	LPS	NNP
cord-015021-pol2qm74	6595	15	were	be	VBD
cord-015021-pol2qm74	6595	16	detected	detect	VBN
cord-015021-pol2qm74	6595	17	by	by	IN
cord-015021-pol2qm74	6595	18	cytotoxic	cytotoxic	JJ
cord-015021-pol2qm74	6595	19	assay	assay	NN
cord-015021-pol2qm74	6595	20	.	.	.
cord-015021-pol2qm74	6596	1	Results	result	NNS
cord-015021-pol2qm74	6596	2	and	and	CC
cord-015021-pol2qm74	6596	3	(	(	-LRB-
cord-015021-pol2qm74	6596	4	bnclnsions	bnclnsion	NNS
cord-015021-pol2qm74	6596	5	:	:	:
cord-015021-pol2qm74	6596	6	I	i	NN
cord-015021-pol2qm74	6596	7	)	)	-RRB-
cord-015021-pol2qm74	6597	1	In	in	IN
cord-015021-pol2qm74	6597	2	vitro	vitro	FW
cord-015021-pol2qm74	6597	3	cultures	culture	NNS
cord-015021-pol2qm74	6597	4	of	of	IN
cord-015021-pol2qm74	6597	5	PEM	PEM	NNP
cord-015021-pol2qm74	6597	6	with	with	IN
cord-015021-pol2qm74	6597	7	BGC	BGC	NNP
cord-015021-pol2qm74	6597	8	have	have	VBP
cord-015021-pol2qm74	6597	9	induced	induce	VBN
cord-015021-pol2qm74	6597	10	enhanced	enhance	VBN
cord-015021-pol2qm74	6597	11	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	6597	12	and	and	CC
cord-015021-pol2qm74	6597	13	bactecidal	bactecidal	JJ
cord-015021-pol2qm74	6597	14	activities	activity	NNS
cord-015021-pol2qm74	6597	15	in	in	IN
cord-015021-pol2qm74	6597	16	C3H	c3h	NN
cord-015021-pol2qm74	6597	17	/	/	SYM
cord-015021-pol2qm74	6597	18	HeN	HeN	NNS
cord-015021-pol2qm74	6597	19	and	and	CC
cord-015021-pol2qm74	6597	20	C3H	c3h	RB
cord-015021-pol2qm74	6597	21	/	/	SYM
cord-015021-pol2qm74	6597	22	HeJ	hej	NN
cord-015021-pol2qm74	6597	23	mice	mouse	NNS
cord-015021-pol2qm74	6597	24	,	,	,
cord-015021-pol2qm74	6597	25	whereas	whereas	IN
cord-015021-pol2qm74	6597	26	LPS	LPS	NNP
cord-015021-pol2qm74	6597	27	only	only	RB
cord-015021-pol2qm74	6597	28	induced	induce	VBD
cord-015021-pol2qm74	6597	29	such	such	JJ
cord-015021-pol2qm74	6597	30	activities	activity	NNS
cord-015021-pol2qm74	6597	31	in	in	IN
cord-015021-pol2qm74	6597	32	C3H	c3h	NN
cord-015021-pol2qm74	6597	33	/	/	SYM
cord-015021-pol2qm74	6597	34	HeN	hen	JJ
cord-015021-pol2qm74	6597	35	mice	mouse	NNS
cord-015021-pol2qm74	6597	36	.	.	.
cord-015021-pol2qm74	6598	1	Most	Most	JJS
cord-015021-pol2qm74	6598	2	effective	effective	JJ
cord-015021-pol2qm74	6598	3	dose	dose	NN
cord-015021-pol2qm74	6598	4	of	of	IN
cord-015021-pol2qm74	6598	5	BGC	BGC	NNP
cord-015021-pol2qm74	6598	6	was	be	VBD
cord-015021-pol2qm74	6599	1	10	10	CD
cord-015021-pol2qm74	6599	2	ug	ug	NNP
cord-015021-pol2qm74	6599	3	/	/	SYM
cord-015021-pol2qm74	6599	4	ml	ml	NN
cord-015021-pol2qm74	6599	5	.	.	NNP
cord-015021-pol2qm74	6599	6	2	2	LS
cord-015021-pol2qm74	6599	7	)	)	-RRB-
cord-015021-pol2qm74	6599	8	BGC	BGC	NNP
cord-015021-pol2qm74	6599	9	-	-	HYPH
cord-015021-pol2qm74	6599	10	dependent	dependent	JJ
cord-015021-pol2qm74	6599	11	proliferative	proliferative	JJ
cord-015021-pol2qm74	6599	12	response	response	NN
cord-015021-pol2qm74	6599	13	of	of	IN
cord-015021-pol2qm74	6599	14	C3H	c3h	NN
cord-015021-pol2qm74	6599	15	/	/	SYM
cord-015021-pol2qm74	6599	16	HeN	hen	NN
cord-015021-pol2qm74	6599	17	splenic	splenic	JJ
cord-015021-pol2qm74	6599	18	cells	cell	NNS
cord-015021-pol2qm74	6599	19	was	be	VBD
cord-015021-pol2qm74	6599	20	not	not	RB
cord-015021-pol2qm74	6599	21	detected	detect	VBN
cord-015021-pol2qm74	6599	22	under	under	IN
cord-015021-pol2qm74	6599	23	the	the	DT
cord-015021-pol2qm74	6599	24	culture	culture	NN
cord-015021-pol2qm74	6599	25	condition	condition	NN
cord-015021-pol2qm74	6599	26	used	use	VBN
cord-015021-pol2qm74	6599	27	.	.	.
cord-015021-pol2qm74	6600	1	3	3	LS
cord-015021-pol2qm74	6600	2	)	)	-RRB-
cord-015021-pol2qm74	6600	3	Induction	induction	NN
cord-015021-pol2qm74	6600	4	of	of	IN
cord-015021-pol2qm74	6600	5	TNF~	tnf~	CD
cord-015021-pol2qm74	6600	6	prodction	prodction	NN
cord-015021-pol2qm74	6600	7	was	be	VBD
cord-015021-pol2qm74	6600	8	apparently	apparently	RB
cord-015021-pol2qm74	6600	9	observed	observe	VBN
cord-015021-pol2qm74	6600	10	in	in	IN
cord-015021-pol2qm74	6600	11	BGC	BGC	NNP
cord-015021-pol2qm74	6600	12	-	-	HYPH
cord-015021-pol2qm74	6600	13	stimulated	stimulate	VBN
cord-015021-pol2qm74	6600	14	C3H	c3h	JJ
cord-015021-pol2qm74	6600	15	/	/	SYM
cord-015021-pol2qm74	6600	16	HeJ	hej	NN
cord-015021-pol2qm74	6600	17	PD4	PD4	NNP
cord-015021-pol2qm74	6600	18	cultures	culture	NNS
cord-015021-pol2qm74	6600	19	,	,	,
cord-015021-pol2qm74	6600	20	but	but	CC
cord-015021-pol2qm74	6600	21	not	not	RB
cord-015021-pol2qm74	6600	22	in	in	IN
cord-015021-pol2qm74	6600	23	LPS	LPS	NNP
cord-015021-pol2qm74	6600	24	stimulated	stimulate	VBD
cord-015021-pol2qm74	6600	25	one	one	CD
cord-015021-pol2qm74	6600	26	.	.	.
cord-015021-pol2qm74	6601	1	These	these	DT
cord-015021-pol2qm74	6601	2	findings	finding	NNS
cord-015021-pol2qm74	6601	3	indicate	indicate	VBP
cord-015021-pol2qm74	6601	4	that	that	IN
cord-015021-pol2qm74	6601	5	activation	activation	NN
cord-015021-pol2qm74	6601	6	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6601	7	of	of	IN
cord-015021-pol2qm74	6601	8	Pr94	Pr94	NNP
cord-015021-pol2qm74	6601	9	and	and	CC
cord-015021-pol2qm74	6601	10	splenic	splenic	JJ
cord-015021-pol2qm74	6601	11	cells	cell	NNS
cord-015021-pol2qm74	6601	12	by	by	IN
cord-015021-pol2qm74	6601	13	BGC	BGC	NNP
cord-015021-pol2qm74	6601	14	are	be	VBP
cord-015021-pol2qm74	6601	15	different	different	JJ
cord-015021-pol2qm74	6601	16	from	from	IN
cord-015021-pol2qm74	6601	17	that	that	DT
cord-015021-pol2qm74	6601	18	by	by	IN
cord-015021-pol2qm74	6601	19	LPS	lp	NNS
cord-015021-pol2qm74	6601	20	.	.	.
cord-015021-pol2qm74	6602	1	To	to	TO
cord-015021-pol2qm74	6602	2	investigate	investigate	VB
cord-015021-pol2qm74	6602	3	the	the	DT
cord-015021-pol2qm74	6602	4	BSC	BSC	NNP
cord-015021-pol2qm74	6602	5	-	-	HYPH
cord-015021-pol2qm74	6602	6	induced	induce	VBN
cord-015021-pol2qm74	6602	7	P~4	P~4	NNP
cord-015021-pol2qm74	6602	8	activation	activation	NN
cord-015021-pol2qm74	6602	9	,	,	,
cord-015021-pol2qm74	6602	10	intracellular	intracellular	JJ
cord-015021-pol2qm74	6602	11	signaling	signal	VBG
cord-015021-pol2qm74	6602	12	pathways	pathway	NNS
cord-015021-pol2qm74	6602	13	of	of	IN
cord-015021-pol2qm74	6602	14	P~4	P~4	NNP
cord-015021-pol2qm74	6602	15	by	by	IN
cord-015021-pol2qm74	6602	16	BGC	BGC	NNP
cord-015021-pol2qm74	6602	17	-	-	HYPH
cord-015021-pol2qm74	6602	18	stimulation	stimulation	NN
cord-015021-pol2qm74	6602	19	are	be	VBP
cord-015021-pol2qm74	6602	20	under	under	IN
cord-015021-pol2qm74	6602	21	consideration	consideration	NN
cord-015021-pol2qm74	6602	22	.	.	.
cord-015021-pol2qm74	6603	1	Yamagami	Yamagami	NNP
cord-015021-pol2qm74	6603	2	K	K	NNP
cord-015021-pol2qm74	6603	3	,	,	,
cord-015021-pol2qm74	6603	4	Uedono	Uedono	NNP
cord-015021-pol2qm74	6603	5	Y	Y	NNP
cord-015021-pol2qm74	6603	6	,	,	,
cord-015021-pol2qm74	6603	7	Kawakami	Kawakami	NNP
cord-015021-pol2qm74	6603	8	K	K	NNP
cord-015021-pol2qm74	6603	9	,	,	,
cord-015021-pol2qm74	6603	10	Kitazawa	Kitazawa	NNP
cord-015021-pol2qm74	6603	11	Y	Y	NNP
cord-015021-pol2qm74	6603	12	and	and	CC
cord-015021-pol2qm74	6603	13	Tanaka	Tanaka	NNP
cord-015021-pol2qm74	6603	14	T	T	NNP
cord-015021-pol2qm74	6604	1	According	accord	VBG
cord-015021-pol2qm74	6604	2	to	to	IN
cord-015021-pol2qm74	6604	3	the	the	DT
cord-015021-pol2qm74	6604	4	latest	late	JJS
cord-015021-pol2qm74	6604	5	reports	report	NNS
cord-015021-pol2qm74	6604	6	of	of	IN
cord-015021-pol2qm74	6604	7	use	use	NN
cord-015021-pol2qm74	6604	8	of	of	IN
cord-015021-pol2qm74	6604	9	IL-2	IL-2	NNP
cord-015021-pol2qm74	6604	10	in	in	IN
cord-015021-pol2qm74	6604	11	a	a	DT
cord-015021-pol2qm74	6604	12	burned	burn	VBN
cord-015021-pol2qm74	6604	13	-	-	HYPH
cord-015021-pol2qm74	6604	14	sepsis	sepsis	NN
cord-015021-pol2qm74	6604	15	model	model	NN
cord-015021-pol2qm74	6604	16	,	,	,
cord-015021-pol2qm74	6604	17	the	the	DT
cord-015021-pol2qm74	6604	18	dose	dose	NN
cord-015021-pol2qm74	6604	19	was	be	VBD
cord-015021-pol2qm74	6604	20	too	too	RB
cord-015021-pol2qm74	6604	21	high	high	JJ
cord-015021-pol2qm74	6604	22	to	to	TO
cord-015021-pol2qm74	6604	23	adjust	adjust	VB
cord-015021-pol2qm74	6604	24	for	for	IN
cord-015021-pol2qm74	6604	25	human	human	JJ
cord-015021-pol2qm74	6604	26	therapy	therapy	NN
cord-015021-pol2qm74	6604	27	.	.	.
cord-015021-pol2qm74	6605	1	Adoptive	adoptive	JJ
cord-015021-pol2qm74	6605	2	transfer	transfer	NN
cord-015021-pol2qm74	6605	3	of	of	IN
cord-015021-pol2qm74	6605	4	L	L	NNP
cord-015021-pol2qm74	6605	5	~	~	CD
cord-015021-pol2qm74	6605	6	ymphokine	ymphokine	NN
cord-015021-pol2qm74	6605	7	-	-	HYPH
cord-015021-pol2qm74	6605	8	activated	activate	VBN
cord-015021-pol2qm74	6605	9	killer	killer	NN
cord-015021-pol2qm74	6605	10	(	(	-LRB-
cord-015021-pol2qm74	6605	11	LAK	LAK	NNP
cord-015021-pol2qm74	6605	12	)	)	-RRB-
cord-015021-pol2qm74	6605	13	cells	cell	NNS
cord-015021-pol2qm74	6605	14	has	have	VBZ
cord-015021-pol2qm74	6605	15	been	be	VBN
cord-015021-pol2qm74	6605	16	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	6605	17	as	as	IN
cord-015021-pol2qm74	6605	18	a	a	DT
cord-015021-pol2qm74	6605	19	means	means	NN
cord-015021-pol2qm74	6605	20	of	of	IN
cord-015021-pol2qm74	6605	21	enhancing	enhance	VBG
cord-015021-pol2qm74	6605	22	therapy	therapy	NN
cord-015021-pol2qm74	6605	23	in	in	IN
cord-015021-pol2qm74	6605	24	malignant	malignant	JJ
cord-015021-pol2qm74	6605	25	tumors	tumor	NNS
cord-015021-pol2qm74	6605	26	.	.	.
cord-015021-pol2qm74	6606	1	We	-PRON-	PRP
cord-015021-pol2qm74	6606	2	therefore	therefore	RB
cord-015021-pol2qm74	6606	3	attempt	attempt	VBP
cord-015021-pol2qm74	6606	4	to	to	TO
cord-015021-pol2qm74	6606	5	use	use	VB
cord-015021-pol2qm74	6606	6	LAK	LAK	NNP
cord-015021-pol2qm74	6606	7	therapy	therapy	NN
cord-015021-pol2qm74	6606	8	on	on	IN
cord-015021-pol2qm74	6606	9	burned	burn	VBN
cord-015021-pol2qm74	6606	10	-	-	HYPH
cord-015021-pol2qm74	6606	11	infected	infect	VBN
cord-015021-pol2qm74	6606	12	mice	mouse	NNS
cord-015021-pol2qm74	6606	13	instead	instead	RB
cord-015021-pol2qm74	6606	14	of	of	IN
cord-015021-pol2qm74	6606	15	IL-2	IL-2	NNP
cord-015021-pol2qm74	6606	16	.	.	.
cord-015021-pol2qm74	6607	1	Under	under	IN
cord-015021-pol2qm74	6607	2	anesthesia	anesthesia	NN
cord-015021-pol2qm74	6607	3	,	,	,
cord-015021-pol2qm74	6607	4	8-weekold	8-weekold	CD
cord-015021-pol2qm74	6607	5	male	male	JJ
cord-015021-pol2qm74	6607	6	C3H	c3h	NN
cord-015021-pol2qm74	6607	7	-	-	HYPH
cord-015021-pol2qm74	6607	8	Hej	Hej	NNP
cord-015021-pol2qm74	6607	9	mice	mouse	NNS
cord-015021-pol2qm74	6607	10	were	be	VBD
cord-015021-pol2qm74	6607	11	subjected	subject	VBN
cord-015021-pol2qm74	6607	12	to	to	IN
cord-015021-pol2qm74	6607	13	a	a	DT
cord-015021-pol2qm74	6607	14	20	20	CD
cord-015021-pol2qm74	6607	15	%	%	NN
cord-015021-pol2qm74	6607	16	scald	scald	NN
cord-015021-pol2qm74	6607	17	or	or	CC
cord-015021-pol2qm74	6607	18	sham	sham	NN
cord-015021-pol2qm74	6607	19	burn	burn	NN
cord-015021-pol2qm74	6607	20	and	and	CC
cord-015021-pol2qm74	6607	21	then	then	RB
cord-015021-pol2qm74	6607	22	resuscitated	resuscitate	VBD
cord-015021-pol2qm74	6607	23	.	.	.
cord-015021-pol2qm74	6608	1	Sham	Sham	NNP
cord-015021-pol2qm74	6608	2	burned	burn	VBD
cord-015021-pol2qm74	6608	3	mice	mouse	NNS
cord-015021-pol2qm74	6608	4	served	serve	VBD
cord-015021-pol2qm74	6608	5	as	as	IN
cord-015021-pol2qm74	6608	6	controls	control	NNS
cord-015021-pol2qm74	6608	7	.	.	.
cord-015021-pol2qm74	6609	1	Scald	scald	VB
cord-015021-pol2qm74	6609	2	burn	burn	VB
cord-015021-pol2qm74	6610	1	mice	mouse	NNS
cord-015021-pol2qm74	6610	2	were	be	VBD
cord-015021-pol2qm74	6610	3	subjected	subject	VBN
cord-015021-pol2qm74	6610	4	to	to	IN
cord-015021-pol2qm74	6610	5	peritonitis	peritonitis	NN
cord-015021-pol2qm74	6610	6	by	by	IN
cord-015021-pol2qm74	6610	7	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	6610	8	innoculation	innoculation	NN
cord-015021-pol2qm74	6610	9	of	of	IN
cord-015021-pol2qm74	6610	10	105	105	CD
cord-015021-pol2qm74	6610	11	organisms	organism	NNS
cord-015021-pol2qm74	6610	12	of	of	IN
cord-015021-pol2qm74	6610	13	P.	P.	NNP
cord-015021-pol2qm74	6610	14	aeruginosa	aeruginosa	NNP
cord-015021-pol2qm74	6610	15	24	24	CD
cord-015021-pol2qm74	6610	16	hr	hr	NN
cord-015021-pol2qm74	6610	17	after	after	IN
cord-015021-pol2qm74	6610	18	burn	burn	NN
cord-015021-pol2qm74	6610	19	.	.	.
cord-015021-pol2qm74	6611	1	Burned	burn	VBN
cord-015021-pol2qm74	6611	2	-	-	HYPH
cord-015021-pol2qm74	6611	3	infected	infect	VBN
cord-015021-pol2qm74	6611	4	-	-	HYPH
cord-015021-pol2qm74	6611	5	mice	mouse	NNS
cord-015021-pol2qm74	6611	6	were	be	VBD
cord-015021-pol2qm74	6611	7	divided	divide	VBN
cord-015021-pol2qm74	6611	8	into	into	IN
cord-015021-pol2qm74	6611	9	two	two	CD
cord-015021-pol2qm74	6611	10	groups	group	NNS
cord-015021-pol2qm74	6611	11	.	.	.
cord-015021-pol2qm74	6612	1	One	one	CD
cord-015021-pol2qm74	6612	2	group	group	NN
cord-015021-pol2qm74	6612	3	had	have	VBD
cord-015021-pol2qm74	6612	4	no	no	DT
cord-015021-pol2qm74	6612	5	further	further	JJ
cord-015021-pol2qm74	6612	6	treatment	treatment	NN
cord-015021-pol2qm74	6612	7	,	,	,
cord-015021-pol2qm74	6612	8	and	and	CC
cord-015021-pol2qm74	6612	9	the	the	DT
cord-015021-pol2qm74	6612	10	other	other	JJ
cord-015021-pol2qm74	6612	11	group	group	NN
cord-015021-pol2qm74	6612	12	received	receive	VBD
cord-015021-pol2qm74	6612	13	LAK	LAK	NNP
cord-015021-pol2qm74	6612	14	cells	cell	NNS
cord-015021-pol2qm74	6612	15	(	(	-LRB-
cord-015021-pol2qm74	6612	16	2x105	2x105	CD
cord-015021-pol2qm74	6612	17	)	)	-RRB-
cord-015021-pol2qm74	6612	18	intraperitonelly	intraperitonelly	NN
cord-015021-pol2qm74	6612	19	after	after	IN
cord-015021-pol2qm74	6612	20	septic	septic	JJ
cord-015021-pol2qm74	6612	21	challenge	challenge	NN
cord-015021-pol2qm74	6612	22	.	.	.
cord-015021-pol2qm74	6613	1	The	the	DT
cord-015021-pol2qm74	6613	2	mice	mouse	NNS
cord-015021-pol2qm74	6613	3	were	be	VBD
cord-015021-pol2qm74	6613	4	scored	score	VBN
cord-015021-pol2qm74	6613	5	for	for	IN
cord-015021-pol2qm74	6613	6	survival	survival	NN
cord-015021-pol2qm74	6613	7	daily	daily	RB
cord-015021-pol2qm74	6613	8	.	.	.
cord-015021-pol2qm74	6614	1	On	on	IN
cord-015021-pol2qm74	6614	2	day	day	NN
cord-015021-pol2qm74	6614	3	7	7	CD
cord-015021-pol2qm74	6614	4	after	after	IN
cord-015021-pol2qm74	6614	5	burn	burn	NN
cord-015021-pol2qm74	6614	6	,	,	,
cord-015021-pol2qm74	6614	7	Using	use	VBG
cord-015021-pol2qm74	6614	8	Moabs	Moabs	NNPS
cord-015021-pol2qm74	6614	9	dual	dual	JJ
cord-015021-pol2qm74	6614	10	-	-	HYPH
cord-015021-pol2qm74	6614	11	color	color	NN
cord-015021-pol2qm74	6614	12	flow	flow	NN
cord-015021-pol2qm74	6614	13	cytometry	cytometry	NN
cord-015021-pol2qm74	6614	14	,	,	,
cord-015021-pol2qm74	6614	15	we	-PRON-	PRP
cord-015021-pol2qm74	6614	16	studied	study	VBD
cord-015021-pol2qm74	6614	17	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	6614	18	expression	expression	NN
cord-015021-pol2qm74	6614	19	in	in	IN
cord-015021-pol2qm74	6614	20	mice	mouse	NNS
cord-015021-pol2qm74	6614	21	with	with	IN
cord-015021-pol2qm74	6614	22	use	use	NN
cord-015021-pol2qm74	6614	23	of	of	IN
cord-015021-pol2qm74	6614	24	blood	blood	NN
cord-015021-pol2qm74	6614	25	and	and	CC
cord-015021-pol2qm74	6614	26	spleen	spleen	NNS
cord-015021-pol2qm74	6614	27	.	.	.
cord-015021-pol2qm74	6615	1	Simultaneousely	Simultaneousely	NNP
cord-015021-pol2qm74	6615	2	we	-PRON-	PRP
cord-015021-pol2qm74	6615	3	studied	study	VBD
cord-015021-pol2qm74	6615	4	the	the	DT
cord-015021-pol2qm74	6615	5	alteration	alteration	NN
cord-015021-pol2qm74	6615	6	of	of	IN
cord-015021-pol2qm74	6615	7	IL-1	IL-1	NNP
cord-015021-pol2qm74	6615	8	and	and	CC
cord-015021-pol2qm74	6615	9	IL-6	IL-6	NNP
cord-015021-pol2qm74	6615	10	in	in	IN
cord-015021-pol2qm74	6615	11	their	-PRON-	PRP$
cord-015021-pol2qm74	6615	12	serum	serum	NN
cord-015021-pol2qm74	6615	13	using	use	VBG
cord-015021-pol2qm74	6615	14	immunoassy	immunoassy	NN
cord-015021-pol2qm74	6615	15	kits	kit	NNS
cord-015021-pol2qm74	6615	16	.	.	.
cord-015021-pol2qm74	6616	1	Sham	Sham	NNP
cord-015021-pol2qm74	6616	2	burned	burn	VBD
cord-015021-pol2qm74	6616	3	animals	animal	NNS
cord-015021-pol2qm74	6616	4	had	have	VBD
cord-015021-pol2qm74	6616	5	no	no	DT
cord-015021-pol2qm74	6616	6	mortality	mortality	NN
cord-015021-pol2qm74	6616	7	.	.	.
cord-015021-pol2qm74	6617	1	The	the	DT
cord-015021-pol2qm74	6617	2	mortality	mortality	NN
cord-015021-pol2qm74	6617	3	of	of	IN
cord-015021-pol2qm74	6617	4	the	the	DT
cord-015021-pol2qm74	6617	5	LAK	LAK	NNP
cord-015021-pol2qm74	6617	6	-	-	HYPH
cord-015021-pol2qm74	6617	7	treated	treat	VBN
cord-015021-pol2qm74	6617	8	mice	mouse	NNS
cord-015021-pol2qm74	6617	9	was	be	VBD
cord-015021-pol2qm74	6617	10	significantly	significantly	RB
cord-015021-pol2qm74	6617	11	reduced	reduce	VBN
cord-015021-pol2qm74	6617	12	when	when	WRB
cord-015021-pol2qm74	6617	13	compared	compare	VBN
cord-015021-pol2qm74	6617	14	with	with	IN
cord-015021-pol2qm74	6617	15	that	that	DT
cord-015021-pol2qm74	6617	16	of	of	IN
cord-015021-pol2qm74	6617	17	the	the	DT
cord-015021-pol2qm74	6617	18	burned	burn	VBN
cord-015021-pol2qm74	6617	19	-	-	HYPH
cord-015021-pol2qm74	6617	20	infected	infect	VBN
cord-015021-pol2qm74	6617	21	mice	mouse	NNS
cord-015021-pol2qm74	6617	22	.	.	.
cord-015021-pol2qm74	6618	1	The	the	DT
cord-015021-pol2qm74	6618	2	most	most	RBS
cord-015021-pol2qm74	6618	3	consistent	consistent	JJ
cord-015021-pol2qm74	6618	4	changes	change	NNS
cord-015021-pol2qm74	6618	5	observed	observe	VBD
cord-015021-pol2qm74	6618	6	were	be	VBD
cord-015021-pol2qm74	6618	7	depressions	depression	NNS
cord-015021-pol2qm74	6618	8	in	in	IN
cord-015021-pol2qm74	6618	9	percentages	percentage	NNS
cord-015021-pol2qm74	6618	10	of	of	IN
cord-015021-pol2qm74	6618	11	Thyl	Thyl	NNP
cord-015021-pol2qm74	6618	12	,	,	,
cord-015021-pol2qm74	6618	13	2	2	CD
cord-015021-pol2qm74	6618	14	positive	positive	JJ
cord-015021-pol2qm74	6618	15	cells	cell	NNS
cord-015021-pol2qm74	6618	16	and	and	CC
cord-015021-pol2qm74	6618	17	a	a	DT
cord-015021-pol2qm74	6618	18	remarkable	remarkable	JJ
cord-015021-pol2qm74	6618	19	depression	depression	NN
cord-015021-pol2qm74	6618	20	of	of	IN
cord-015021-pol2qm74	6618	21	NK	NK	NNP
cord-015021-pol2qm74	6618	22	cells	cell	NNS
cord-015021-pol2qm74	6618	23	in	in	IN
cord-015021-pol2qm74	6618	24	spleen	spleen	NN
cord-015021-pol2qm74	6618	25	.	.	.
cord-015021-pol2qm74	6619	1	After	after	IN
cord-015021-pol2qm74	6619	2	LAK	LAK	NNP
cord-015021-pol2qm74	6619	3	cell	cell	NN
cord-015021-pol2qm74	6619	4	treatment	treatment	NN
cord-015021-pol2qm74	6619	5	,	,	,
cord-015021-pol2qm74	6619	6	those	those	DT
cord-015021-pol2qm74	6619	7	two	two	CD
cord-015021-pol2qm74	6619	8	percentages	percentage	NNS
cord-015021-pol2qm74	6619	9	of	of	IN
cord-015021-pol2qm74	6619	10	cells	cell	NNS
cord-015021-pol2qm74	6619	11	significantly	significantly	RB
cord-015021-pol2qm74	6619	12	increased	increase	VBD
cord-015021-pol2qm74	6619	13	.	.	.
cord-015021-pol2qm74	6620	1	All	all	PDT
cord-015021-pol2qm74	6620	2	the	the	DT
cord-015021-pol2qm74	6620	3	data	datum	NNS
cord-015021-pol2qm74	6620	4	of	of	IN
cord-015021-pol2qm74	6620	5	assay	assay	NN
cord-015021-pol2qm74	6620	6	of	of	IN
cord-015021-pol2qm74	6620	7	ILl	ILl	NNS
cord-015021-pol2qm74	6620	8	and	and	CC
cord-015021-pol2qm74	6620	9	[	[	-LRB-
cord-015021-pol2qm74	6620	10	L	L	NNP
cord-015021-pol2qm74	6620	11	6	6	CD
cord-015021-pol2qm74	6620	12	were	be	VBD
cord-015021-pol2qm74	6620	13	not	not	RB
cord-015021-pol2qm74	6620	14	detected	detect	VBN
cord-015021-pol2qm74	6620	15	on	on	IN
cord-015021-pol2qm74	6620	16	sham	sham	NN
cord-015021-pol2qm74	6620	17	burn	burn	NN
cord-015021-pol2qm74	6620	18	mice	mouse	NNS
cord-015021-pol2qm74	6620	19	serum	serum	NN
cord-015021-pol2qm74	6620	20	.	.	.
cord-015021-pol2qm74	6621	1	Due	due	IN
cord-015021-pol2qm74	6621	2	to	to	TO
cord-015021-pol2qm74	6621	3	burn	burn	VB
cord-015021-pol2qm74	6621	4	and	and	CC
cord-015021-pol2qm74	6621	5	septic	septic	JJ
cord-015021-pol2qm74	6621	6	challenge	challenge	NN
cord-015021-pol2qm74	6621	7	the	the	DT
cord-015021-pol2qm74	6621	8	levels	level	NNS
cord-015021-pol2qm74	6621	9	of	of	IN
cord-015021-pol2qm74	6621	10	ILland	ILland	NNP
cord-015021-pol2qm74	6621	11	IL	IL	NNP
cord-015021-pol2qm74	6621	12	6	6	CD
cord-015021-pol2qm74	6621	13	(	(	-LRB-
cord-015021-pol2qm74	6621	14	n=6	n=6	NNP
cord-015021-pol2qm74	6621	15	)	)	-RRB-
cord-015021-pol2qm74	6621	16	were	be	VBD
cord-015021-pol2qm74	6621	17	raised	raise	VBN
cord-015021-pol2qm74	6621	18	to	to	IN
cord-015021-pol2qm74	6621	19	45.9_+17.4	45.9_+17.4	CD
cord-015021-pol2qm74	6621	20	and	and	CC
cord-015021-pol2qm74	6621	21	3866_+1045	3866_+1045	CD
cord-015021-pol2qm74	6621	22	pg	pg	NNP
cord-015021-pol2qm74	6621	23	/	/	SYM
cord-015021-pol2qm74	6621	24	ml	ml	XX
cord-015021-pol2qm74	6621	25	,	,	,
cord-015021-pol2qm74	6621	26	while	while	IN
cord-015021-pol2qm74	6621	27	the	the	DT
cord-015021-pol2qm74	6621	28	levels	level	NNS
cord-015021-pol2qm74	6621	29	in	in	IN
cord-015021-pol2qm74	6621	30	LAK	LAK	NNP
cord-015021-pol2qm74	6621	31	treated	treat	VBD
cord-015021-pol2qm74	6621	32	mice	mouse	NNS
cord-015021-pol2qm74	6621	33	were	be	VBD
cord-015021-pol2qm74	6621	34	reduced	reduce	VBN
cord-015021-pol2qm74	6621	35	to	to	IN
cord-015021-pol2qm74	6621	36	4.23_+2.37	4.23_+2.37	CD
cord-015021-pol2qm74	6621	37	and	and	CC
cord-015021-pol2qm74	6621	38	437_+110	437_+110	CD
cord-015021-pol2qm74	6621	39	pg	pg	NNP
cord-015021-pol2qm74	6621	40	/	/	SYM
cord-015021-pol2qm74	6621	41	ml	ml	NNS
cord-015021-pol2qm74	6621	42	,	,	,
cord-015021-pol2qm74	6621	43	respectively	respectively	RB
cord-015021-pol2qm74	6621	44	.	.	.
cord-015021-pol2qm74	6622	1	The	the	DT
cord-015021-pol2qm74	6622	2	results	result	NNS
cord-015021-pol2qm74	6622	3	reported	report	VBN
cord-015021-pol2qm74	6622	4	here	here	RB
cord-015021-pol2qm74	6622	5	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	6622	6	that	that	IN
cord-015021-pol2qm74	6622	7	LAK	LAK	NNP
cord-015021-pol2qm74	6622	8	therapy	therapy	NN
cord-015021-pol2qm74	6622	9	is	be	VBZ
cord-015021-pol2qm74	6622	10	able	able	JJ
cord-015021-pol2qm74	6622	11	to	to	TO
cord-015021-pol2qm74	6622	12	improve	improve	VB
cord-015021-pol2qm74	6622	13	cell	cell	NN
cord-015021-pol2qm74	6622	14	-	-	HYPH
cord-015021-pol2qm74	6622	15	mediated	mediate	VBN
cord-015021-pol2qm74	6622	16	immunity	immunity	NN
cord-015021-pol2qm74	6622	17	in	in	IN
cord-015021-pol2qm74	6622	18	burned	burn	VBN
cord-015021-pol2qm74	6622	19	-	-	HYPH
cord-015021-pol2qm74	6622	20	infected	infect	VBN
cord-015021-pol2qm74	6622	21	mice	mouse	NNS
cord-015021-pol2qm74	6622	22	.	.	.
cord-015021-pol2qm74	6623	1	This	this	DT
cord-015021-pol2qm74	6623	2	is	be	VBZ
cord-015021-pol2qm74	6623	3	associated	associate	VBN
cord-015021-pol2qm74	6623	4	with	with	IN
cord-015021-pol2qm74	6623	5	a	a	DT
cord-015021-pol2qm74	6623	6	significantly	significantly	RB
cord-015021-pol2qm74	6623	7	improved	improve	VBN
cord-015021-pol2qm74	6623	8	survival	survival	NN
cord-015021-pol2qm74	6623	9	rate	rate	NN
cord-015021-pol2qm74	6623	10	,	,	,
cord-015021-pol2qm74	6623	11	since	since	IN
cord-015021-pol2qm74	6623	12	ILl	ILl	NNP
cord-015021-pol2qm74	6623	13	has	have	VBZ
cord-015021-pol2qm74	6623	14	been	be	VBN
cord-015021-pol2qm74	6623	15	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	6623	16	to	to	TO
cord-015021-pol2qm74	6623	17	mediate	mediate	VB
cord-015021-pol2qm74	6623	18	immune	immune	JJ
cord-015021-pol2qm74	6623	19	and	and	CC
cord-015021-pol2qm74	6623	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6623	21	responses	response	NNS
cord-015021-pol2qm74	6623	22	.	.	.
cord-015021-pol2qm74	6624	1	Also	also	RB
cord-015021-pol2qm74	6624	2	a	a	DT
cord-015021-pol2qm74	6624	3	cause	cause	NN
cord-015021-pol2qm74	6624	4	effect	effect	NN
cord-015021-pol2qm74	6624	5	relationship	relationship	NN
cord-015021-pol2qm74	6624	6	between	between	IN
cord-015021-pol2qm74	6624	7	elevated	elevated	JJ
cord-015021-pol2qm74	6624	8	endetoxin	endetoxin	NN
cord-015021-pol2qm74	6624	9	levels	level	NNS
cord-015021-pol2qm74	6624	10	and	and	CC
cord-015021-pol2qm74	6624	11	increases	increase	NNS
cord-015021-pol2qm74	6624	12	of	of	IN
cord-015021-pol2qm74	6624	13	[	[	-LRB-
cord-015021-pol2qm74	6624	14	L6	L6	NNP
cord-015021-pol2qm74	6624	15	has	have	VBZ
cord-015021-pol2qm74	6624	16	been	be	VBN
cord-015021-pol2qm74	6624	17	recently	recently	RB
cord-015021-pol2qm74	6624	18	established	establish	VBN
cord-015021-pol2qm74	6624	19	.	.	.
cord-015021-pol2qm74	6625	1	The	the	DT
cord-015021-pol2qm74	6625	2	aim	aim	NN
cord-015021-pol2qm74	6625	3	of	of	IN
cord-015021-pol2qm74	6625	4	our	-PRON-	PRP$
cord-015021-pol2qm74	6625	5	present	present	JJ
cord-015021-pol2qm74	6625	6	study	study	NN
cord-015021-pol2qm74	6625	7	was	be	VBD
cord-015021-pol2qm74	6625	8	to	to	TO
cord-015021-pol2qm74	6625	9	investigate	investigate	VB
cord-015021-pol2qm74	6625	10	the	the	DT
cord-015021-pol2qm74	6625	11	effect	effect	NN
cord-015021-pol2qm74	6625	12	of	of	IN
cord-015021-pol2qm74	6625	13	parenteral	parenteral	JJ
cord-015021-pol2qm74	6625	14	indomethacin	indomethacin	NN
cord-015021-pol2qm74	6625	15	on	on	IN
cord-015021-pol2qm74	6625	16	the	the	DT
cord-015021-pol2qm74	6625	17	immune	immune	JJ
cord-015021-pol2qm74	6625	18	system	system	NN
cord-015021-pol2qm74	6625	19	of	of	IN
cord-015021-pol2qm74	6625	20	patients	patient	NNS
cord-015021-pol2qm74	6625	21	under	under	IN
cord-015021-pol2qm74	6625	22	major	major	JJ
cord-015021-pol2qm74	6625	23	operations	operation	NNS
cord-015021-pol2qm74	6625	24	.	.	.
cord-015021-pol2qm74	6626	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	6626	2	study	study	NN
cord-015021-pol2qm74	6626	3	included	include	VBD
cord-015021-pol2qm74	6626	4	20	20	CD
cord-015021-pol2qm74	6626	5	operated	operate	VBN
cord-015021-pol2qm74	6626	6	patients	patient	NNS
cord-015021-pol2qm74	6626	7	,	,	,
cord-015021-pol2qm74	6626	8	10	10	CD
cord-015021-pol2qm74	6626	9	of	of	IN
cord-015021-pol2qm74	6626	10	which	which	WDT
cord-015021-pol2qm74	6626	11	received	receive	VBD
cord-015021-pol2qm74	6626	12	100	100	CD
cord-015021-pol2qm74	6626	13	mg	mg	NNP
cord-015021-pol2qm74	6626	14	indomethacin	indomethacin	NN
cord-015021-pol2qm74	6626	15	before	before	RB
cord-015021-pol2qm74	6626	16	and	and	CC
cord-015021-pol2qm74	6626	17	1,2	1,2	CD
cord-015021-pol2qm74	6626	18	and	and	CC
cord-015021-pol2qm74	6626	19	3	3	CD
cord-015021-pol2qm74	6626	20	days	day	NNS
cord-015021-pol2qm74	6626	21	after	after	IN
cord-015021-pol2qm74	6626	22	surgery	surgery	NN
cord-015021-pol2qm74	6626	23	(	(	-LRB-
cord-015021-pol2qm74	6626	24	group	group	NN
cord-015021-pol2qm74	6626	25	A	A	NNP
cord-015021-pol2qm74	6626	26	)	)	-RRB-
cord-015021-pol2qm74	6626	27	and	and	CC
cord-015021-pol2qm74	6626	28	10	10	CD
cord-015021-pol2qm74	6626	29	patients	patient	NNS
cord-015021-pol2qm74	6626	30	received	receive	VBD
cord-015021-pol2qm74	6626	31	no	no	DT
cord-015021-pol2qm74	6626	32	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	6626	33	therapy	therapy	NN
cord-015021-pol2qm74	6626	34	(	(	-LRB-
cord-015021-pol2qm74	6626	35	group	group	NN
cord-015021-pol2qm74	6626	36	B	B	NNP
cord-015021-pol2qm74	6626	37	)	)	-RRB-
cord-015021-pol2qm74	6626	38	.	.	.
cord-015021-pol2qm74	6627	1	We	-PRON-	PRP
cord-015021-pol2qm74	6627	2	measured	measure	VBD
cord-015021-pol2qm74	6627	3	total	total	JJ
cord-015021-pol2qm74	6627	4	T	T	NNP
cord-015021-pol2qm74	6627	5	-	-	HYPH
cord-015021-pol2qm74	6627	6	cells	cell	NNS
cord-015021-pol2qm74	6627	7	helper	helper	NN
cord-015021-pol2qm74	6627	8	(	(	-LRB-
cord-015021-pol2qm74	6627	9	CD4	CD4	NNP
cord-015021-pol2qm74	6627	10	)	)	-RRB-
cord-015021-pol2qm74	6627	11	,	,	,
cord-015021-pol2qm74	6627	12	suppressor	suppressor	NN
cord-015021-pol2qm74	6627	13	(	(	-LRB-
cord-015021-pol2qm74	6627	14	CD8	CD8	NNP
cord-015021-pol2qm74	6627	15	)	)	-RRB-
cord-015021-pol2qm74	6627	16	,	,	,
cord-015021-pol2qm74	6627	17	NK	NK	NNP
cord-015021-pol2qm74	6627	18	-	-	HYPH
cord-015021-pol2qm74	6627	19	cells	cell	NNS
cord-015021-pol2qm74	6627	20	and	and	CC
cord-015021-pol2qm74	6627	21	interleukin-1	interleukin-1	NN
cord-015021-pol2qm74	6627	22	and	and	CC
cord-015021-pol2qm74	6627	23	TNF	TNF	NNP
cord-015021-pol2qm74	6627	24	production	production	NN
cord-015021-pol2qm74	6627	25	by	by	IN
cord-015021-pol2qm74	6627	26	PHA	PHA	NNP
cord-015021-pol2qm74	6627	27	or	or	CC
cord-015021-pol2qm74	6627	28	endodoxin	endodoxin	NNP
cord-015021-pol2qm74	6627	29	(	(	-LRB-
cord-015021-pol2qm74	6627	30	LPS	LPS	NNP
cord-015021-pol2qm74	6627	31	)	)	-RRB-
cord-015021-pol2qm74	6627	32	stimulated	stimulate	VBD
cord-015021-pol2qm74	6627	33	peripheral	peripheral	JJ
cord-015021-pol2qm74	6627	34	blood	blood	NN
cord-015021-pol2qm74	6627	35	mononuclear	mononuclear	NN
cord-015021-pol2qm74	6627	36	cells	cell	NNS
cord-015021-pol2qm74	6627	37	at	at	IN
cord-015021-pol2qm74	6627	38	day	day	NN
cord-015021-pol2qm74	6627	39	0	0	CD
cord-015021-pol2qm74	6627	40	and	and	CC
cord-015021-pol2qm74	6627	41	1	1	CD
cord-015021-pol2qm74	6627	42	,	,	,
cord-015021-pol2qm74	6627	43	3	3	CD
cord-015021-pol2qm74	6627	44	and	and	CC
cord-015021-pol2qm74	6627	45	7	7	CD
cord-015021-pol2qm74	6627	46	days	day	NNS
cord-015021-pol2qm74	6627	47	after	after	IN
cord-015021-pol2qm74	6627	48	operation	operation	NN
cord-015021-pol2qm74	6627	49	.	.	.
cord-015021-pol2qm74	6628	1	In	in	IN
cord-015021-pol2qm74	6628	2	group	group	NN
cord-015021-pol2qm74	6628	3	A	A	NNP
cord-015021-pol2qm74	6628	4	we	-PRON-	PRP
cord-015021-pol2qm74	6628	5	detected	detect	VBD
cord-015021-pol2qm74	6628	6	a	a	DT
cord-015021-pol2qm74	6628	7	significant	significant	JJ
cord-015021-pol2qm74	6628	8	(	(	-LRB-
cord-015021-pol2qm74	6628	9	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6628	10	)	)	-RRB-
cord-015021-pol2qm74	6628	11	increase	increase	NN
cord-015021-pol2qm74	6628	12	in	in	IN
cord-015021-pol2qm74	6628	13	CD4	CD4	NNP
cord-015021-pol2qm74	6628	14	/	/	SYM
cord-015021-pol2qm74	6628	15	CD8	CD8	NNP
cord-015021-pol2qm74	6628	16	ratio	ratio	NN
cord-015021-pol2qm74	6628	17	on	on	IN
cord-015021-pol2qm74	6628	18	day	day	NN
cord-015021-pol2qm74	6628	19	3	3	CD
cord-015021-pol2qm74	6628	20	while	while	IN
cord-015021-pol2qm74	6628	21	no	no	DT
cord-015021-pol2qm74	6628	22	differences	difference	NNS
cord-015021-pol2qm74	6628	23	were	be	VBD
cord-015021-pol2qm74	6628	24	~oted	~ote	VBN
cord-015021-pol2qm74	6628	25	in	in	IN
cord-015021-pol2qm74	6628	26	NK	NK	NNP
cord-015021-pol2qm74	6628	27	-	-	HYPH
cord-015021-pol2qm74	6628	28	cells	cell	NNS
cord-015021-pol2qm74	6628	29	or	or	CC
cord-015021-pol2qm74	6628	30	cytokine	cytokine	NN
cord-015021-pol2qm74	6628	31	production	production	NN
cord-015021-pol2qm74	6628	32	in	in	IN
cord-015021-pol2qm74	6628	33	both	both	DT
cord-015021-pol2qm74	6628	34	groups	group	NNS
cord-015021-pol2qm74	6628	35	(	(	-LRB-
cord-015021-pol2qm74	6628	36	Table	table	NN
cord-015021-pol2qm74	6628	37	1	1	CD
cord-015021-pol2qm74	6628	38	)	)	-RRB-
cord-015021-pol2qm74	6628	39	.	.	.
cord-015021-pol2qm74	6629	1	It	-PRON-	PRP
cord-015021-pol2qm74	6629	2	seems	seem	VBZ
cord-015021-pol2qm74	6629	3	,	,	,
cord-015021-pol2qm74	6629	4	therefore	therefore	RB
cord-015021-pol2qm74	6629	5	,	,	,
cord-015021-pol2qm74	6629	6	that	that	IN
cord-015021-pol2qm74	6629	7	parenterai	parenterai	FW
cord-015021-pol2qm74	6629	8	indomethacin	indomethacin	NNP
cord-015021-pol2qm74	6629	9	may	may	MD
cord-015021-pol2qm74	6629	10	have	have	VB
cord-015021-pol2qm74	6629	11	a	a	DT
cord-015021-pol2qm74	6629	12	benefitial	benefitial	JJ
cord-015021-pol2qm74	6629	13	effect	effect	NN
cord-015021-pol2qm74	6629	14	on	on	IN
cord-015021-pol2qm74	6629	15	the	the	DT
cord-015021-pol2qm74	6629	16	immune	immune	JJ
cord-015021-pol2qm74	6629	17	system	system	NN
cord-015021-pol2qm74	6629	18	of	of	IN
cord-015021-pol2qm74	6629	19	patients	patient	NNS
cord-015021-pol2qm74	6629	20	under	under	IN
cord-015021-pol2qm74	6629	21	major	major	JJ
cord-015021-pol2qm74	6629	22	operations	operation	NNS
cord-015021-pol2qm74	6629	23	by	by	IN
cord-015021-pol2qm74	6629	24	increasing	increase	VBG
cord-015021-pol2qm74	6629	25	the	the	DT
cord-015021-pol2qm74	6629	26	T	t	NN
cord-015021-pol2qm74	6629	27	-	-	HYPH
cord-015021-pol2qm74	6629	28	helper	helper	NN
cord-015021-pol2qm74	6629	29	/T	/T	.
cord-015021-pol2qm74	6629	30	-	-	HYPH
cord-015021-pol2qm74	6629	31	suppressor	suppressor	NN
cord-015021-pol2qm74	6629	32	cell	cell	NN
cord-015021-pol2qm74	6629	33	ratio	ratio	NN
cord-015021-pol2qm74	6629	34	while	while	IN
cord-015021-pol2qm74	6629	35	having	have	VBG
cord-015021-pol2qm74	6629	36	no	no	DT
cord-015021-pol2qm74	6629	37	effect	effect	NN
cord-015021-pol2qm74	6629	38	on	on	IN
cord-015021-pol2qm74	6629	39	the	the	DT
cord-015021-pol2qm74	6629	40	production	production	NN
cord-015021-pol2qm74	6629	41	of	of	IN
cord-015021-pol2qm74	6629	42	cytokines	cytokine	NNS
cord-015021-pol2qm74	6629	43	by	by	IN
cord-015021-pol2qm74	6629	44	peripheral	peripheral	JJ
cord-015021-pol2qm74	6629	45	blood	blood	NN
cord-015021-pol2qm74	6629	46	mononuclear	mononuclear	NN
cord-015021-pol2qm74	6629	47	cells	cell	NNS
cord-015021-pol2qm74	6629	48	.	.	.
cord-015021-pol2qm74	6630	1	This	this	DT
cord-015021-pol2qm74	6630	2	study	study	NN
cord-015021-pol2qm74	6630	3	was	be	VBD
cord-015021-pol2qm74	6630	4	undertaken	undertake	VBN
cord-015021-pol2qm74	6630	5	tD	td	CD
cord-015021-pol2qm74	6630	6	dete	dete	NNP
cord-015021-pol2qm74	6630	7	~	~	NFP
cord-015021-pol2qm74	6630	8	nnine	nnine	VB
cord-015021-pol2qm74	6630	9	the	the	DT
cord-015021-pol2qm74	6630	10	role	role	NN
cord-015021-pol2qm74	6630	11	of	of	IN
cord-015021-pol2qm74	6630	12	prostaglandin	prostaglandin	JJ
cord-015021-pol2qm74	6630	13	synthesis	synthesis	NN
cord-015021-pol2qm74	6630	14	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6630	15	on	on	IN
cord-015021-pol2qm74	6630	16	survival	survival	NNP
cord-015021-pol2qm74	6630	17	post	post	NN
cord-015021-pol2qm74	6630	18	traulna	traulna	NNP
cord-015021-pol2qm74	6630	19	sepsis	sepsis	NN
cord-015021-pol2qm74	6630	20	.	.	.
cord-015021-pol2qm74	6631	1	Analysis	analysis	NN
cord-015021-pol2qm74	6631	2	of	of	IN
cord-015021-pol2qm74	6631	3	the	the	DT
cord-015021-pol2qm74	6631	4	effects	effect	NNS
cord-015021-pol2qm74	6631	5	of	of	IN
cord-015021-pol2qm74	6631	6	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	6631	7	synthesis	synthesis	NN
cord-015021-pol2qm74	6631	8	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6631	9	on	on	IN
cord-015021-pol2qm74	6631	10	survival	survival	NN
cord-015021-pol2qm74	6631	11	of	of	IN
cord-015021-pol2qm74	6631	12	four	four	CD
cord-015021-pol2qm74	6631	13	groups	group	NNS
cord-015021-pol2qm74	6631	14	of	of	IN
cord-015021-pol2qm74	6631	15	15	15	CD
cord-015021-pol2qm74	6631	16	mice	mouse	NNS
cord-015021-pol2qm74	6631	17	each	each	DT
cord-015021-pol2qm74	6631	18	were	be	VBD
cord-015021-pol2qm74	6631	19	made	make	VBN
cord-015021-pol2qm74	6631	20	after	after	IN
cord-015021-pol2qm74	6631	21	laparatomy	laparatomy	NN
cord-015021-pol2qm74	6631	22	and	and	CC
cord-015021-pol2qm74	6631	23	intravenous	intravenous	JJ
cord-015021-pol2qm74	6631	24	administration	administration	NN
cord-015021-pol2qm74	6631	25	of	of	IN
cord-015021-pol2qm74	6631	26	live	live	JJ
cord-015021-pol2qm74	6631	27	E.coli	E.coli	NNS
cord-015021-pol2qm74	6631	28	.	.	.
cord-015021-pol2qm74	6632	1	Post	post	JJ
cord-015021-pol2qm74	6632	2	trauma	trauma	NN
cord-015021-pol2qm74	6632	3	sepsis	sepsis	NN
cord-015021-pol2qm74	6632	4	,	,	,
cord-015021-pol2qm74	6632	5	Group	Group	NNP
cord-015021-pol2qm74	6632	6	A	A	NNP
cord-015021-pol2qm74	6632	7	received	receive	VBD
cord-015021-pol2qm74	6632	8	no	no	DT
cord-015021-pol2qm74	6632	9	treatment	treatment	NN
cord-015021-pol2qm74	6632	10	;	;	:
cord-015021-pol2qm74	6632	11	Group	Group	NNP
cord-015021-pol2qm74	6632	12	B	B	NNP
cord-015021-pol2qm74	6632	13	received	receive	VBD
cord-015021-pol2qm74	6632	14	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6632	15	IM	im	JJ
cord-015021-pol2qm74	6632	16	;	;	:
cord-015021-pol2qm74	6632	17	Group	Group	NNP
cord-015021-pol2qm74	6632	18	C	C	NNP
cord-015021-pol2qm74	6632	19	received	receive	VBD
cord-015021-pol2qm74	6632	20	prostaglandin	prostaglandin	JJ
cord-015021-pol2qm74	6632	21	synthesis	synthesis	NN
cord-015021-pol2qm74	6632	22	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6632	23	IM	IM	NNP
cord-015021-pol2qm74	6632	24	and	and	CC
cord-015021-pol2qm74	6632	25	Group	Group	NNP
cord-015021-pol2qm74	6632	26	D	D	NNP
cord-015021-pol2qm74	6632	27	received	receive	VBD
cord-015021-pol2qm74	6632	28	both	both	DT
cord-015021-pol2qm74	6632	29	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6632	30	and	and	CC
cord-015021-pol2qm74	6632	31	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	6632	32	synthesis	synthesis	NN
cord-015021-pol2qm74	6632	33	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6632	34	IM	IM	NNP
cord-015021-pol2qm74	6632	35	.	.	.
cord-015021-pol2qm74	6633	1	Survival	survival	NN
cord-015021-pol2qm74	6633	2	time	time	NN
cord-015021-pol2qm74	6633	3	was	be	VBD
cord-015021-pol2qm74	6633	4	longest	long	JJS
cord-015021-pol2qm74	6633	5	in	in	IN
cord-015021-pol2qm74	6633	6	group	group	NN
cord-015021-pol2qm74	6633	7	treated	treat	VBN
cord-015021-pol2qm74	6633	8	with	with	IN
cord-015021-pol2qm74	6633	9	prostaglandin	prostaglandin	JJ
cord-015021-pol2qm74	6633	10	synthesis	synthesis	NN
cord-015021-pol2qm74	6633	11	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6633	12	and	and	CC
cord-015021-pol2qm74	6633	13	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6633	14	post	post	VBP
cord-015021-pol2qm74	6633	15	trauma	trauma	NN
cord-015021-pol2qm74	6633	16	sepsis	sepsis	NN
cord-015021-pol2qm74	6633	17	.	.	.
cord-015021-pol2qm74	6634	1	The	the	DT
cord-015021-pol2qm74	6634	2	singular	singular	JJ
cord-015021-pol2qm74	6634	3	use	use	NN
cord-015021-pol2qm74	6634	4	of	of	IN
cord-015021-pol2qm74	6634	5	either	either	CC
cord-015021-pol2qm74	6634	6	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	6634	7	or	or	CC
cord-015021-pol2qm74	6634	8	prostaglandin	prostaglandin	JJ
cord-015021-pol2qm74	6634	9	synthesis	synthesis	NN
cord-015021-pol2qm74	6634	10	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6634	11	did	do	VBD
cord-015021-pol2qm74	6634	12	not	not	RB
cord-015021-pol2qm74	6634	13	alter	alter	VB
cord-015021-pol2qm74	6634	14	the	the	DT
cord-015021-pol2qm74	6634	15	outcome	outcome	NN
cord-015021-pol2qm74	6634	16	on	on	IN
cord-015021-pol2qm74	6634	17	survival	survival	NN
cord-015021-pol2qm74	6634	18	.	.	.
cord-015021-pol2qm74	6635	1	Mortality	mortality	NN
cord-015021-pol2qm74	6635	2	rate	rate	NN
cord-015021-pol2qm74	6635	3	was	be	VBD
cord-015021-pol2qm74	6635	4	lowest	low	JJS
cord-015021-pol2qm74	6635	5	in	in	IN
cord-015021-pol2qm74	6635	6	the	the	DT
cord-015021-pol2qm74	6635	7	group	group	NN
cord-015021-pol2qm74	6635	8	treated	treat	VBN
cord-015021-pol2qm74	6635	9	with	with	IN
cord-015021-pol2qm74	6635	10	combined	combined	JJ
cord-015021-pol2qm74	6635	11	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	6635	12	synthesis	synthesis	NN
cord-015021-pol2qm74	6635	13	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6635	14	and	and	CC
cord-015021-pol2qm74	6635	15	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	6635	16	.	.	.
cord-015021-pol2qm74	6636	1	Use	use	NN
cord-015021-pol2qm74	6636	2	of	of	IN
cord-015021-pol2qm74	6636	3	this	this	DT
cord-015021-pol2qm74	6636	4	combination	combination	NN
cord-015021-pol2qm74	6636	5	showed	show	VBD
cord-015021-pol2qm74	6636	6	a	a	DT
cord-015021-pol2qm74	6636	7	reduction	reduction	NN
cord-015021-pol2qm74	6636	8	in	in	IN
cord-015021-pol2qm74	6636	9	bacterial	bacterial	JJ
cord-015021-pol2qm74	6636	10	growth	growth	NN
cord-015021-pol2qm74	6636	11	in	in	IN
cord-015021-pol2qm74	6636	12	peritoneal	peritoneal	NN
cord-015021-pol2qm74	6636	13	and	and	CC
cord-015021-pol2qm74	6636	14	blood	blood	NN
cord-015021-pol2qm74	6636	15	samples	sample	NNS
cord-015021-pol2qm74	6636	16	,	,	,
cord-015021-pol2qm74	6636	17	mild	mild	JJ
cord-015021-pol2qm74	6636	18	morphologic	morphologic	JJ
cord-015021-pol2qm74	6636	19	changes	change	NNS
cord-015021-pol2qm74	6636	20	secondary	secondary	JJ
cord-015021-pol2qm74	6636	21	to	to	IN
cord-015021-pol2qm74	6636	22	sepsis	sepsis	NN
cord-015021-pol2qm74	6636	23	in	in	IN
cord-015021-pol2qm74	6636	24	the	the	DT
cord-015021-pol2qm74	6636	25	heart	heart	NN
cord-015021-pol2qm74	6636	26	,	,	,
cord-015021-pol2qm74	6636	27	lungs	lung	NNS
cord-015021-pol2qm74	6636	28	,	,	,
cord-015021-pol2qm74	6636	29	liver	liver	NN
cord-015021-pol2qm74	6636	30	,	,	,
cord-015021-pol2qm74	6636	31	kidney	kidney	NN
cord-015021-pol2qm74	6636	32	and	and	CC
cord-015021-pol2qm74	6636	33	stomach	stomach	NN
cord-015021-pol2qm74	6636	34	and	and	CC
cord-015021-pol2qm74	6636	35	marked	marked	JJ
cord-015021-pol2qm74	6636	36	enhancement	enhancement	NN
cord-015021-pol2qm74	6636	37	of	of	IN
cord-015021-pol2qm74	6636	38	mean	mean	JJ
cord-015021-pol2qm74	6636	39	level	level	NN
cord-015021-pol2qm74	6636	40	of	of	IN
cord-015021-pol2qm74	6636	41	activity	activity	NN
cord-015021-pol2qm74	6636	42	.	.	.
cord-015021-pol2qm74	6637	1	The	the	DT
cord-015021-pol2qm74	6637	2	study	study	NN
cord-015021-pol2qm74	6637	3	indicates	indicate	VBZ
cord-015021-pol2qm74	6637	4	that	that	IN
cord-015021-pol2qm74	6637	5	addition	addition	NN
cord-015021-pol2qm74	6637	6	of	of	IN
cord-015021-pol2qm74	6637	7	prostaglandin	prostaglandin	JJ
cord-015021-pol2qm74	6637	8	synthesis	synthesis	NN
cord-015021-pol2qm74	6637	9	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6637	10	in	in	IN
cord-015021-pol2qm74	6637	11	treatment	treatment	NN
cord-015021-pol2qm74	6637	12	of	of	IN
cord-015021-pol2qm74	6637	13	trauma	trauma	NN
cord-015021-pol2qm74	6637	14	-	-	HYPH
cord-015021-pol2qm74	6637	15	sepsis	sepsis	NN
cord-015021-pol2qm74	6637	16	has	have	VBZ
cord-015021-pol2qm74	6637	17	clear	clear	JJ
cord-015021-pol2qm74	6637	18	beneficial	beneficial	JJ
cord-015021-pol2qm74	6637	19	effects	effect	NNS
cord-015021-pol2qm74	6637	20	.	.	.
cord-015021-pol2qm74	6638	1	Interferon-	Interferon-	NNP
cord-015021-pol2qm74	6638	2	?	?	.
cord-015021-pol2qm74	6639	1	(	(	-LRB-
cord-015021-pol2qm74	6639	2	IFN	IFN	NNP
cord-015021-pol2qm74	6639	3	-	-	HYPH
cord-015021-pol2qm74	6639	4	y	y	NNP
cord-015021-pol2qm74	6639	5	)	)	-RRB-
cord-015021-pol2qm74	6639	6	is	be	VBZ
cord-015021-pol2qm74	6639	7	a	a	DT
cord-015021-pol2qm74	6639	8	potent	potent	JJ
cord-015021-pol2qm74	6639	9	immunostimulant	immunostimulant	NN
cord-015021-pol2qm74	6639	10	which	which	WDT
cord-015021-pol2qm74	6639	11	has	have	VBZ
cord-015021-pol2qm74	6639	12	been	be	VBN
cord-015021-pol2qm74	6639	13	shown	show	VBN
cord-015021-pol2qm74	6639	14	to	to	TO
cord-015021-pol2qm74	6639	15	be	be	VB
cord-015021-pol2qm74	6639	16	detrimental	detrimental	JJ
cord-015021-pol2qm74	6639	17	when	when	WRB
cord-015021-pol2qm74	6639	18	administered	administer	VBN
cord-015021-pol2qm74	6639	19	during	during	IN
cord-015021-pol2qm74	6639	20	septic	septic	JJ
cord-015021-pol2qm74	6639	21	shock	shock	NN
cord-015021-pol2qm74	6639	22	.	.	.
cord-015021-pol2qm74	6640	1	Blockade	blockade	NN
cord-015021-pol2qm74	6640	2	of	of	IN
cord-015021-pol2qm74	6640	3	this	this	DT
cord-015021-pol2qm74	6640	4	cytokine	cytokine	NN
cord-015021-pol2qm74	6640	5	however	however	RB
cord-015021-pol2qm74	6640	6	is	be	VBZ
cord-015021-pol2qm74	6640	7	beneficial	beneficial	JJ
cord-015021-pol2qm74	6640	8	during	during	IN
cord-015021-pol2qm74	6640	9	the	the	DT
cord-015021-pol2qm74	6640	10	acute	acute	JJ
cord-015021-pol2qm74	6640	11	septic	septic	JJ
cord-015021-pol2qm74	6640	12	response	response	NN
cord-015021-pol2qm74	6640	13	.	.	.
cord-015021-pol2qm74	6641	1	The	the	DT
cord-015021-pol2qm74	6641	2	aim	aim	NN
cord-015021-pol2qm74	6641	3	of	of	IN
cord-015021-pol2qm74	6641	4	this	this	DT
cord-015021-pol2qm74	6641	5	study	study	NN
cord-015021-pol2qm74	6641	6	was	be	VBD
cord-015021-pol2qm74	6641	7	to	to	TO
cord-015021-pol2qm74	6641	8	evaluate	evaluate	VB
cord-015021-pol2qm74	6641	9	the	the	DT
cord-015021-pol2qm74	6641	10	cellular	cellular	JJ
cord-015021-pol2qm74	6641	11	effects	effect	NNS
cord-015021-pol2qm74	6641	12	of	of	IN
cord-015021-pol2qm74	6641	13	this	this	DT
cord-015021-pol2qm74	6641	14	cytokine	cytokine	NN
cord-015021-pol2qm74	6641	15	and	and	CC
cord-015021-pol2qm74	6641	16	its	-PRON-	PRP$
cord-015021-pol2qm74	6641	17	blocking	block	VBG
cord-015021-pol2qm74	6641	18	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	6641	19	antibody	antibody	NN
cord-015021-pol2qm74	6641	20	(	(	-LRB-
cord-015021-pol2qm74	6641	21	MoAb	MoAb	NNP
cord-015021-pol2qm74	6641	22	)	)	-RRB-
cord-015021-pol2qm74	6641	23	in	in	IN
cord-015021-pol2qm74	6641	24	lethal	lethal	JJ
cord-015021-pol2qm74	6641	25	sepsis	sepsis	NN
cord-015021-pol2qm74	6641	26	following	follow	VBG
cord-015021-pol2qm74	6641	27	injury	injury	NN
cord-015021-pol2qm74	6641	28	.	.	.
cord-015021-pol2qm74	6642	1	100	100	CD
cord-015021-pol2qm74	6642	2	female	female	JJ
cord-015021-pol2qm74	6642	3	CD-1	CD-1	NNP
cord-015021-pol2qm74	6642	4	mice	mouse	NNS
cord-015021-pol2qm74	6642	5	were	be	VBD
cord-015021-pol2qm74	6642	6	randomized	randomize	VBN
cord-015021-pol2qm74	6642	7	into	into	IN
cord-015021-pol2qm74	6642	8	two	two	CD
cord-015021-pol2qm74	6642	9	groups	group	NNS
cord-015021-pol2qm74	6642	10	:	:	:
cord-015021-pol2qm74	6642	11	Septic	septic	NN
cord-015021-pol2qm74	6642	12	=	=	SYM
cord-015021-pol2qm74	6642	13	LPS	LPS	NNP
cord-015021-pol2qm74	6642	14	vs	vs	IN
cord-015021-pol2qm74	6642	15	injury	injury	NN
cord-015021-pol2qm74	6642	16	=	=	SYM
cord-015021-pol2qm74	6642	17	hind	hind	NN
cord-015021-pol2qm74	6642	18	limb	limb	NN
cord-015021-pol2qm74	6642	19	amputation	amputation	NN
cord-015021-pol2qm74	6643	1	(	(	-LRB-
cord-015021-pol2qm74	6643	2	HLA	HLA	NNP
cord-015021-pol2qm74	6643	3	vs	vs	IN
cord-015021-pol2qm74	6643	4	IgG.	IgG.	NNP
cord-015021-pol2qm74	6644	1	nStats=	nStats=	NNP
cord-015021-pol2qm74	6644	2	ANOVA=	ANOVA=	NNP
cord-015021-pol2qm74	6645	1	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6646	1	vs	vs	IN
cord-015021-pol2qm74	6646	2	lgG	lgG	NNP
cord-015021-pol2qm74	6646	3	IFN	IFN	NNP
cord-015021-pol2qm74	6646	4	-	-	HYPH
cord-015021-pol2qm74	6646	5	y	y	NNP
cord-015021-pol2qm74	6646	6	was	be	VBD
cord-015021-pol2qm74	6646	7	detrimental	detrimental	JJ
cord-015021-pol2qm74	6646	8	when	when	WRB
cord-015021-pol2qm74	6646	9	given	give	VBN
cord-015021-pol2qm74	6646	10	to	to	TO
cord-015021-pol2qm74	6646	11	control	control	VB
cord-015021-pol2qm74	6646	12	septic	septic	JJ
cord-015021-pol2qm74	6646	13	animals	animal	NNS
cord-015021-pol2qm74	6646	14	.	.	.
cord-015021-pol2qm74	6647	1	However	however	RB
cord-015021-pol2qm74	6647	2	its	-PRON-	PRP$
cord-015021-pol2qm74	6647	3	blocking	block	VBG
cord-015021-pol2qm74	6647	4	MoAb	MoAb	NNP
cord-015021-pol2qm74	6647	5	was	be	VBD
cord-015021-pol2qm74	6647	6	protective	protective	JJ
cord-015021-pol2qm74	6647	7	(	(	-LRB-
cord-015021-pol2qm74	6647	8	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6647	9	)	)	-RRB-
cord-015021-pol2qm74	6647	10	.	.	.
cord-015021-pol2qm74	6648	1	Conversely	conversely	RB
cord-015021-pol2qm74	6648	2	IFN	IFN	NNP
cord-015021-pol2qm74	6648	3	-	-	HYPH
cord-015021-pol2qm74	6648	4	y	y	NNP
cord-015021-pol2qm74	6648	5	was	be	VBD
cord-015021-pol2qm74	6648	6	proteetive	proteetive	JJ
cord-015021-pol2qm74	6648	7	in	in	IN
cord-015021-pol2qm74	6648	8	injured	injure	VBN
cord-015021-pol2qm74	6648	9	septic	septic	JJ
cord-015021-pol2qm74	6648	10	animals	animal	NNS
cord-015021-pol2qm74	6648	11	compared	compare	VBN
cord-015021-pol2qm74	6648	12	with	with	IN
cord-015021-pol2qm74	6649	1	anti	anti	JJ
cord-015021-pol2qm74	6649	2	-	-	JJ
cord-015021-pol2qm74	6649	3	IFN-	ifn-	JJ
cord-015021-pol2qm74	6649	4	?	?	.
cord-015021-pol2qm74	6649	5	(	(	-LRB-
cord-015021-pol2qm74	6649	6	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6649	7	)	)	-RRB-
cord-015021-pol2qm74	6649	8	.	.	.
cord-015021-pol2qm74	6650	1	These	these	DT
cord-015021-pol2qm74	6650	2	findings	finding	NNS
cord-015021-pol2qm74	6650	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	6650	4	that	that	IN
cord-015021-pol2qm74	6650	5	the	the	DT
cord-015021-pol2qm74	6650	6	immune	immune	JJ
cord-015021-pol2qm74	6650	7	stimulant	stimulant	NN
cord-015021-pol2qm74	6650	8	IFN-	IFN-	NNP
cord-015021-pol2qm74	6650	9	?	?	,
cord-015021-pol2qm74	6650	10	has	have	VBZ
cord-015021-pol2qm74	6650	11	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6650	12	potential	potential	NN
cord-015021-pol2qm74	6650	13	in	in	IN
cord-015021-pol2qm74	6650	14	the	the	DT
cord-015021-pol2qm74	6650	15	immunosuppressed	immunosuppressed	JJ
cord-015021-pol2qm74	6650	16	injured	injure	VBN
cord-015021-pol2qm74	6650	17	host	host	NN
cord-015021-pol2qm74	6650	18	predisposed	predisposed	JJ
cord-015021-pol2qm74	6650	19	to	to	IN
cord-015021-pol2qm74	6650	20	sepsis	sepsis	NN
cord-015021-pol2qm74	6650	21	,	,	,
cord-015021-pol2qm74	6650	22	while	while	IN
cord-015021-pol2qm74	6650	23	blockade	blockade	NN
cord-015021-pol2qm74	6650	24	of	of	IN
cord-015021-pol2qm74	6650	25	this	this	DT
cord-015021-pol2qm74	6650	26	cytokine	cytokine	NN
cord-015021-pol2qm74	6650	27	is	be	VBZ
cord-015021-pol2qm74	6650	28	required	require	VBN
cord-015021-pol2qm74	6650	29	for	for	IN
cord-015021-pol2qm74	6650	30	protection	protection	NN
cord-015021-pol2qm74	6650	31	in	in	IN
cord-015021-pol2qm74	6650	32	the	the	DT
cord-015021-pol2qm74	6650	33	septic	septic	JJ
cord-015021-pol2qm74	6650	34	host	host	NN
cord-015021-pol2qm74	6650	35	with	with	IN
cord-015021-pol2qm74	6650	36	a	a	DT
cord-015021-pol2qm74	6650	37	normal	normal	JJ
cord-015021-pol2qm74	6650	38	immune	immune	JJ
cord-015021-pol2qm74	6650	39	response	response	NN
cord-015021-pol2qm74	6650	40	.	.	.
cord-015021-pol2qm74	6651	1	Dept	Dept	NNP
cord-015021-pol2qm74	6651	2	of	of	IN
cord-015021-pol2qm74	6651	3	Surgery	Surgery	NNP
cord-015021-pol2qm74	6651	4	,	,	,
cord-015021-pol2qm74	6651	5	RCSI	RCSI	NNP
cord-015021-pol2qm74	6651	6	,	,	,
cord-015021-pol2qm74	6651	7	Beaumont	Beaumont	NNP
cord-015021-pol2qm74	6651	8	Hospital	Hospital	NNP
cord-015021-pol2qm74	6651	9	,	,	,
cord-015021-pol2qm74	6651	10	Dublin	Dublin	NNP
cord-015021-pol2qm74	6651	11	9	9	CD
cord-015021-pol2qm74	6651	12	,	,	,
cord-015021-pol2qm74	6651	13	Ireland	Ireland	NNP
cord-015021-pol2qm74	6651	14	.	.	.
cord-015021-pol2qm74	6652	1	Oxidants	oxidant	NNS
cord-015021-pol2qm74	6652	2	play	play	VBP
cord-015021-pol2qm74	6652	3	a	a	DT
cord-015021-pol2qm74	6652	4	role	role	NN
cord-015021-pol2qm74	6652	5	in	in	IN
cord-015021-pol2qm74	6652	6	physiology	physiology	NN
cord-015021-pol2qm74	6652	7	.	.	.
cord-015021-pol2qm74	6653	1	The	the	DT
cord-015021-pol2qm74	6653	2	potential	potential	JJ
cord-015021-pol2qm74	6653	3	noxious	noxious	JJ
cord-015021-pol2qm74	6653	4	oxidant	oxidant	JJ
cord-015021-pol2qm74	6653	5	biochemistry	biochemistry	NN
cord-015021-pol2qm74	6653	6	is	be	VBZ
cord-015021-pol2qm74	6653	7	restrained	restrain	VBN
cord-015021-pol2qm74	6653	8	by	by	IN
cord-015021-pol2qm74	6653	9	chemically	chemically	RB
cord-015021-pol2qm74	6653	10	distinct	distinct	JJ
cord-015021-pol2qm74	6653	11	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6653	12	.	.	.
cord-015021-pol2qm74	6654	1	These	these	DT
cord-015021-pol2qm74	6654	2	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6654	3	,	,	,
cord-015021-pol2qm74	6654	4	which	which	WDT
cord-015021-pol2qm74	6654	5	may	may	MD
cord-015021-pol2qm74	6654	6	reside	reside	VB
cord-015021-pol2qm74	6654	7	in	in	IN
cord-015021-pol2qm74	6654	8	different	different	JJ
cord-015021-pol2qm74	6654	9	cellular	cellular	JJ
cord-015021-pol2qm74	6654	10	compartments	compartment	NNS
cord-015021-pol2qm74	6654	11	,	,	,
cord-015021-pol2qm74	6654	12	can	can	MD
cord-015021-pol2qm74	6654	13	act	act	VB
cord-015021-pol2qm74	6654	14	synergistically	synergistically	RB
cord-015021-pol2qm74	6654	15	.	.	.
cord-015021-pol2qm74	6655	1	In	in	IN
cord-015021-pol2qm74	6655	2	normal	normal	JJ
cord-015021-pol2qm74	6655	3	physiology	physiology	NN
cord-015021-pol2qm74	6655	4	an	an	DT
cord-015021-pol2qm74	6655	5	oxidant	oxidant	JJ
cord-015021-pol2qm74	6655	6	/	/	SYM
cord-015021-pol2qm74	6655	7	antioxidant	antioxidant	NN
cord-015021-pol2qm74	6655	8	bai&nce	bai&nce	NN
cord-015021-pol2qm74	6655	9	exists	exist	VBZ
cord-015021-pol2qm74	6655	10	.	.	.
cord-015021-pol2qm74	6656	1	Unbalance	unbalance	NN
cord-015021-pol2qm74	6656	2	in	in	IN
cord-015021-pol2qm74	6656	3	favour	favour	NN
cord-015021-pol2qm74	6656	4	of	of	IN
cord-015021-pol2qm74	6656	5	the	the	DT
cord-015021-pol2qm74	6656	6	oxidants	oxidant	NNS
cord-015021-pol2qm74	6656	7	is	be	VBZ
cord-015021-pol2qm74	6656	8	called	call	VBN
cord-015021-pol2qm74	6656	9	oxidative	oxidative	JJ
cord-015021-pol2qm74	6656	10	stress	stress	NN
cord-015021-pol2qm74	6656	11	.	.	.
cord-015021-pol2qm74	6657	1	Oxidative	oxidative	JJ
cord-015021-pol2qm74	6657	2	stress	stress	NN
cord-015021-pol2qm74	6657	3	has	have	VBZ
cord-015021-pol2qm74	6657	4	been	be	VBN
cord-015021-pol2qm74	6657	5	implicated	implicate	VBN
cord-015021-pol2qm74	6657	6	in	in	IN
cord-015021-pol2qm74	6657	7	many	many	JJ
cord-015021-pol2qm74	6657	8	pathologies	pathology	NNS
cord-015021-pol2qm74	6657	9	including	include	VBG
cord-015021-pol2qm74	6657	10	lung	lung	NN
cord-015021-pol2qm74	6657	11	diseases(e.g	diseases(e.g	NNP
cord-015021-pol2qm74	6657	12	,	,	,
cord-015021-pol2qm74	6657	13	doxorubicin	doxorubicin	JJ
cord-015021-pol2qm74	6657	14	induced	induce	VBN
cord-015021-pol2qm74	6657	15	cardiotoxicity	cardiotoxicity	NN
cord-015021-pol2qm74	6657	16	)	)	-RRB-
cord-015021-pol2qm74	6657	17	,	,	,
cord-015021-pol2qm74	6657	18	ischemia	ischemia	NN
cord-015021-pol2qm74	6657	19	/	/	SYM
cord-015021-pol2qm74	6657	20	reperfnsion	reperfnsion	NN
cord-015021-pol2qm74	6657	21	damage	damage	NN
cord-015021-pol2qm74	6657	22	and	and	CC
cord-015021-pol2qm74	6657	23	central	central	JJ
cord-015021-pol2qm74	6657	24	nervous	nervous	JJ
cord-015021-pol2qm74	6657	25	system	system	NN
cord-015021-pol2qm74	6657	26	trauma	trauma	NN
cord-015021-pol2qm74	6657	27	.	.	.
cord-015021-pol2qm74	6658	1	Transition	transition	NN
cord-015021-pol2qm74	6658	2	metals	metal	NNS
cord-015021-pol2qm74	6658	3	such	such	JJ
cord-015021-pol2qm74	6658	4	as	as	IN
cord-015021-pol2qm74	6658	5	iron	iron	NN
cord-015021-pol2qm74	6658	6	are	be	VBP
cord-015021-pol2qm74	6658	7	involved	involve	VBN
cord-015021-pol2qm74	6658	8	in	in	IN
cord-015021-pol2qm74	6658	9	the	the	DT
cord-015021-pol2qm74	6658	10	early	early	JJ
cord-015021-pol2qm74	6658	11	events	event	NNS
cord-015021-pol2qm74	6658	12	leading	lead	VBG
cord-015021-pol2qm74	6658	13	to	to	IN
cord-015021-pol2qm74	6658	14	oxidative	oxidative	JJ
cord-015021-pol2qm74	6658	15	damage	damage	NN
cord-015021-pol2qm74	6658	16	in	in	IN
cord-015021-pol2qm74	6658	17	these	these	DT
cord-015021-pol2qm74	6658	18	pathologies	pathology	NNS
cord-015021-pol2qm74	6658	19	.	.	.
cord-015021-pol2qm74	6659	1	This	this	DT
cord-015021-pol2qm74	6659	2	has	have	VBZ
cord-015021-pol2qm74	6659	3	been	be	VBN
cord-015021-pol2qm74	6659	4	underlined	underline	VBN
cord-015021-pol2qm74	6659	5	by	by	IN
cord-015021-pol2qm74	6659	6	the	the	DT
cord-015021-pol2qm74	6659	7	finding	finding	NN
cord-015021-pol2qm74	6659	8	that	that	IN
cord-015021-pol2qm74	6659	9	postischemic	postischemic	JJ
cord-015021-pol2qm74	6659	10	CNS	cns	NN
cord-015021-pol2qm74	6659	11	pathology	pathology	NN
cord-015021-pol2qm74	6659	12	closely	closely	RB
cord-015021-pol2qm74	6659	13	resembles	resemble	VBZ
cord-015021-pol2qm74	6659	14	that	that	IN
cord-015021-pol2qm74	6659	15	caused	cause	VBN
cord-015021-pol2qm74	6659	16	by	by	IN
cord-015021-pol2qm74	6659	17	a	a	DT
cord-015021-pol2qm74	6659	18	chemical	chemical	JJ
cord-015021-pol2qm74	6659	19	oxidative	oxidative	JJ
cord-015021-pol2qm74	6659	20	insult	insult	NN
cord-015021-pol2qm74	6659	21	(	(	-LRB-
cord-015021-pol2qm74	6659	22	e.g.	e.g.	IN
cord-015021-pol2qm74	6659	23	iron	iron	NN
cord-015021-pol2qm74	6659	24	microinjection	microinjection	NN
cord-015021-pol2qm74	6659	25	)	)	-RRB-
cord-015021-pol2qm74	6659	26	.	.	.
cord-015021-pol2qm74	6660	1	Moreover	moreover	RB
cord-015021-pol2qm74	6660	2	,	,	,
cord-015021-pol2qm74	6660	3	a	a	DT
cord-015021-pol2qm74	6660	4	protective	protective	JJ
cord-015021-pol2qm74	6660	5	effect	effect	NN
cord-015021-pol2qm74	6660	6	of	of	IN
cord-015021-pol2qm74	6660	7	oxygen	oxygen	NN
cord-015021-pol2qm74	6660	8	-	-	HYPH
cord-015021-pol2qm74	6660	9	radical	radical	JJ
cord-015021-pol2qm74	6660	10	scavening	scavene	VBG
cord-015021-pol2qm74	6660	11	agents	agent	NNS
cord-015021-pol2qm74	6660	12	or	or	CC
cord-015021-pol2qm74	6660	13	compounds	compound	NNS
cord-015021-pol2qm74	6660	14	that	that	WDT
cord-015021-pol2qm74	6660	15	inhibit	inhibit	VBP
cord-015021-pol2qm74	6660	16	lipid	lipid	NN
cord-015021-pol2qm74	6660	17	peroxidation	peroxidation	NN
cord-015021-pol2qm74	6660	18	(	(	-LRB-
cord-015021-pol2qm74	6660	19	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6660	20	)	)	-RRB-
cord-015021-pol2qm74	6660	21	in	in	IN
cord-015021-pol2qm74	6660	22	brain	brain	NN
cord-015021-pol2qm74	6660	23	ischemia	ischemia	NN
cord-015021-pol2qm74	6660	24	/	/	SYM
cord-015021-pol2qm74	6660	25	trauma	trauma	NN
cord-015021-pol2qm74	6660	26	is	be	VBZ
cord-015021-pol2qm74	6660	27	apparent	apparent	JJ
cord-015021-pol2qm74	6660	28	.	.	.
cord-015021-pol2qm74	6661	1	Some	some	DT
cord-015021-pol2qm74	6661	2	known	know	VBN
cord-015021-pol2qm74	6661	3	drugs	drug	NNS
cord-015021-pol2qm74	6661	4	(	(	-LRB-
cord-015021-pol2qm74	6661	5	e.g.	e.g.	IN
cord-015021-pol2qm74	6661	6	anti	anti	JJ
cord-015021-pol2qm74	6661	7	-	-	NNS
cord-015021-pol2qm74	6661	8	arrhythmics	arrhythmic	NNS
cord-015021-pol2qm74	6661	9	or	or	CC
cord-015021-pol2qm74	6661	10	histamine	histamine	NN
cord-015021-pol2qm74	6661	11	H2-antagonists	h2-antagonist	NNS
cord-015021-pol2qm74	6661	12	may	may	MD
cord-015021-pol2qm74	6661	13	act	act	VB
cord-015021-pol2qm74	6661	14	as	as	IN
cord-015021-pol2qm74	6661	15	non	non	JJ
cord-015021-pol2qm74	6661	16	-	-	JJ
cord-015021-pol2qm74	6661	17	specific	specific	JJ
cord-015021-pol2qm74	6661	18	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6661	19	.	.	.
cord-015021-pol2qm74	6662	1	Howe	Howe	NNP
cord-015021-pol2qm74	6662	2	~	~	NFP
cord-015021-pol2qm74	6662	3	er	er	UH
cord-015021-pol2qm74	6662	4	,	,	,
cord-015021-pol2qm74	6662	5	recently	recently	RB
cord-015021-pol2qm74	6662	6	,	,	,
cord-015021-pol2qm74	6662	7	interesting	interesting	JJ
cord-015021-pol2qm74	6662	8	new	new	JJ
cord-015021-pol2qm74	6662	9	membrancespecific	membrancespecific	NN
cord-015021-pol2qm74	6662	10	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6662	11	(	(	-LRB-
cord-015021-pol2qm74	6662	12	e.g.	e.g.	RB
cord-015021-pol2qm74	6662	13	21-aminosterdids	21-aminosterdids	CD
cord-015021-pol2qm74	6662	14	)	)	-RRB-
cord-015021-pol2qm74	6662	15	have	have	VBP
cord-015021-pol2qm74	6662	16	been	be	VBN
cord-015021-pol2qm74	6662	17	designed	design	VBN
cord-015021-pol2qm74	6662	18	.	.	.
cord-015021-pol2qm74	6663	1	Subt&e	subt&e	CD
cord-015021-pol2qm74	6663	2	effects	effect	NNS
cord-015021-pol2qm74	6663	3	on	on	IN
cord-015021-pol2qm74	6663	4	iron	iron	NN
cord-015021-pol2qm74	6663	5	redox	redox	NN
cord-015021-pol2qm74	6663	6	chemistry	chemistry	NN
cord-015021-pol2qm74	6663	7	contributes	contribute	VBZ
cord-015021-pol2qm74	6663	8	to	to	IN
cord-015021-pol2qm74	6663	9	the	the	DT
cord-015021-pol2qm74	6663	10	potent	potent	JJ
cord-015021-pol2qm74	6663	11	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6663	12	activity	activity	NN
cord-015021-pol2qm74	6663	13	of	of	IN
cord-015021-pol2qm74	6663	14	these	these	DT
cord-015021-pol2qm74	6663	15	21aminosteroids	21aminosteroids	CD
cord-015021-pol2qm74	6663	16	.	.	.
cord-015021-pol2qm74	6664	1	Since	since	IN
cord-015021-pol2qm74	6664	2	a	a	DT
cord-015021-pol2qm74	6664	3	few	few	JJ
cord-015021-pol2qm74	6664	4	years	year	NNS
cord-015021-pol2qm74	6664	5	,	,	,
cord-015021-pol2qm74	6664	6	one	one	CD
cord-015021-pol2qm74	6664	7	area	area	NN
cord-015021-pol2qm74	6664	8	that	that	WDT
cord-015021-pol2qm74	6664	9	greeted	greet	VBD
cord-015021-pol2qm74	6664	10	enthusimastlcally	enthusimastlcally	RB
cord-015021-pol2qm74	6664	11	in	in	IN
cord-015021-pol2qm74	6664	12	clinical	clinical	JJ
cord-015021-pol2qm74	6664	13	medicine	medicine	NN
cord-015021-pol2qm74	6664	14	is	be	VBZ
cord-015021-pol2qm74	6664	15	that	that	DT
cord-015021-pol2qm74	6664	16	of	of	IN
cord-015021-pol2qm74	6664	17	reoxygenatlon	reoxygenatlon	NNP
cord-015021-pol2qm74	6664	18	injury	injury	NN
cord-015021-pol2qm74	6664	19	or	or	CC
cord-015021-pol2qm74	6664	20	ischemia	ischemia	NN
cord-015021-pol2qm74	6664	21	-	-	HYPH
cord-015021-pol2qm74	6664	22	repeffusion	repeffusion	NN
cord-015021-pol2qm74	6664	23	,	,	,
cord-015021-pol2qm74	6664	24	a	a	DT
cord-015021-pol2qm74	6664	25	phenomenon	phenomenon	NN
cord-015021-pol2qm74	6664	26	accepted	accept	VBN
cord-015021-pol2qm74	6664	27	to	to	TO
cord-015021-pol2qm74	6664	28	make	make	VB
cord-015021-pol2qm74	6664	29	a	a	DT
cord-015021-pol2qm74	6664	30	majo	majo	NN
cord-015021-pol2qm74	6664	31	:	:	:
cord-015021-pol2qm74	6664	32	"	"	``
cord-015021-pol2qm74	6664	33	contribution	contribution	NN
cord-015021-pol2qm74	6664	34	to	to	IN
cord-015021-pol2qm74	6664	35	organ	organ	NN
cord-015021-pol2qm74	6664	36	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6664	37	in	in	IN
cord-015021-pol2qm74	6664	38	trauma	trauma	NN
cord-015021-pol2qm74	6664	39	,	,	,
cord-015021-pol2qm74	6664	40	shock	shock	NN
cord-015021-pol2qm74	6664	41	and	and	CC
cord-015021-pol2qm74	6664	42	sepsis	sepsis	NN
cord-015021-pol2qm74	6664	43	through	through	IN
cord-015021-pol2qm74	6664	44	the	the	DT
cord-015021-pol2qm74	6664	45	formation	formation	NN
cord-015021-pol2qm74	6664	46	o	o	NN
cord-015021-pol2qm74	6664	47	(	(	-LRB-
cord-015021-pol2qm74	6664	48	oxygenated	oxygenated	JJ
cord-015021-pol2qm74	6664	49	free	free	JJ
cord-015021-pol2qm74	6664	50	radical	radical	JJ
cord-015021-pol2qm74	6664	51	species	specie	NNS
cord-015021-pol2qm74	6664	52	.	.	.
cord-015021-pol2qm74	6665	1	However	however	RB
cord-015021-pol2qm74	6665	2	,	,	,
cord-015021-pol2qm74	6665	3	thei	thei	PRP$
cord-015021-pol2qm74	6665	4	detection	detection	NN
cord-015021-pol2qm74	6665	5	in	in	IN
cord-015021-pol2qm74	6665	6	vivo	vivo	NN
cord-015021-pol2qm74	6665	7	always	always	RB
cord-015021-pol2qm74	6665	8	remains	remain	VBZ
cord-015021-pol2qm74	6665	9	a	a	DT
cord-015021-pol2qm74	6665	10	difficult	difficult	JJ
cord-015021-pol2qm74	6665	11	challenge	challenge	NN
cord-015021-pol2qm74	6665	12	.	.	.
cord-015021-pol2qm74	6666	1	Efforts	effort	NNS
cord-015021-pol2qm74	6666	2	have	have	VBP
cord-015021-pol2qm74	6666	3	been	be	VBN
cord-015021-pol2qm74	6666	4	made	make	VBN
cord-015021-pol2qm74	6666	5	recently	recently	RB
cord-015021-pol2qm74	6666	6	to	to	TO
cord-015021-pol2qm74	6666	7	directly	directly	RB
cord-015021-pol2qm74	6666	8	establish	establish	VB
cord-015021-pol2qm74	6666	9	the	the	DT
cord-015021-pol2qm74	6666	10	formation	formation	NN
cord-015021-pol2qm74	6666	11	of	of	IN
cord-015021-pol2qm74	6666	12	free	free	JJ
cord-015021-pol2qm74	6666	13	radicals	radical	NNS
cord-015021-pol2qm74	6666	14	in	in	IN
cord-015021-pol2qm74	6666	15	biological	biological	JJ
cord-015021-pol2qm74	6666	16	samples	sample	NNS
cord-015021-pol2qm74	6666	17	as	as	RB
cord-015021-pol2qm74	6666	18	complex	complex	JJ
cord-015021-pol2qm74	6666	19	as	as	IN
cord-015021-pol2qm74	6666	20	blood	blood	NN
cord-015021-pol2qm74	6666	21	,	,	,
cord-015021-pol2qm74	6666	22	plasma	plasma	NN
cord-015021-pol2qm74	6666	23	or	or	CC
cord-015021-pol2qm74	6666	24	tissue	tissue	NN
cord-015021-pol2qm74	6666	25	with	with	IN
cord-015021-pol2qm74	6666	26	the	the	DT
cord-015021-pol2qm74	6666	27	use	use	NN
cord-015021-pol2qm74	6666	28	of	of	IN
cord-015021-pol2qm74	6666	29	electron	electron	NN
cord-015021-pol2qm74	6666	30	spin	spin	NN
cord-015021-pol2qm74	6666	31	resonance	resonance	NN
cord-015021-pol2qm74	6666	32	(	(	-LRB-
cord-015021-pol2qm74	6666	33	esr	esr	NNP
cord-015021-pol2qm74	6666	34	)	)	-RRB-
cord-015021-pol2qm74	6666	35	spectroscopy	spectroscopy	NNP
cord-015021-pol2qm74	6666	36	.	.	.
cord-015021-pol2qm74	6667	1	Using	use	VBG
cord-015021-pol2qm74	6667	2	spin	spin	NN
cord-015021-pol2qm74	6667	3	trapping	trap	VBG
cord-015021-pol2qm74	6667	4	agents	agent	NNS
cord-015021-pol2qm74	6667	5	,	,	,
cord-015021-pol2qm74	6667	6	the	the	DT
cord-015021-pol2qm74	6667	7	presence	presence	NN
cord-015021-pol2qm74	6667	8	of	of	IN
cord-015021-pol2qm74	6667	9	reactive	reactive	JJ
cord-015021-pol2qm74	6667	10	carbon	carbon	NN
cord-015021-pol2qm74	6667	11	-	-	HYPH
cord-015021-pol2qm74	6667	12	and	and	CC
cord-015021-pol2qm74	6667	13	oxygen	oxygen	NN
cord-015021-pol2qm74	6667	14	-	-	HYPH
cord-015021-pol2qm74	6667	15	centered	center	VBN
cord-015021-pol2qm74	6667	16	radicals	radical	NNS
cord-015021-pol2qm74	6667	17	has	have	VBZ
cord-015021-pol2qm74	6667	18	been	be	VBN
cord-015021-pol2qm74	6667	19	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	6667	20	in	in	IN
cord-015021-pol2qm74	6667	21	animals	animal	NNS
cord-015021-pol2qm74	6667	22	blood	blood	NN
cord-015021-pol2qm74	6667	23	submitted	submit	VBN
cord-015021-pol2qm74	6667	24	to	to	IN
cord-015021-pol2qm74	6667	25	heart	heart	NN
cord-015021-pol2qm74	6667	26	,	,	,
cord-015021-pol2qm74	6667	27	renal	renal	JJ
cord-015021-pol2qm74	6667	28	and	and	CC
cord-015021-pol2qm74	6667	29	intestinal	intestinal	JJ
cord-015021-pol2qm74	6667	30	ischemia	ischemia	NN
cord-015021-pol2qm74	6667	31	-	-	HYPH
cord-015021-pol2qm74	6667	32	repeffusion	repeffusion	NN
cord-015021-pol2qm74	6667	33	or	or	CC
cord-015021-pol2qm74	6667	34	to	to	IN
cord-015021-pol2qm74	6667	35	liver	liver	NN
cord-015021-pol2qm74	6667	36	transplantation	transplantation	NN
cord-015021-pol2qm74	6667	37	.	.	.
cord-015021-pol2qm74	6668	1	Recently	recently	RB
cord-015021-pol2qm74	6668	2	,	,	,
cord-015021-pol2qm74	6668	3	the	the	DT
cord-015021-pol2qm74	6668	4	in	in	IN
cord-015021-pol2qm74	6668	5	vivo	vivo	NN
cord-015021-pol2qm74	6668	6	formation	formation	NN
cord-015021-pol2qm74	6668	7	of	of	IN
cord-015021-pol2qm74	6668	8	free	free	JJ
cord-015021-pol2qm74	6668	9	radicals	radical	NNS
cord-015021-pol2qm74	6668	10	in	in	IN
cord-015021-pol2qm74	6668	11	the	the	DT
cord-015021-pol2qm74	6668	12	cerebra	cerebra	NN
cord-015021-pol2qm74	6668	13	;	;	:
cord-015021-pol2qm74	6668	14	extracellnlar	extracellnlar	JJ
cord-015021-pol2qm74	6668	15	fluid	fluid	NN
cord-015021-pol2qm74	6668	16	during	during	IN
cord-015021-pol2qm74	6668	17	cerebral	cerebral	JJ
cord-015021-pol2qm74	6668	18	isehemia	isehemia	NN
cord-015021-pol2qm74	6668	19	-	-	HYPH
cord-015021-pol2qm74	6668	20	repeffusion	repeffusion	NNP
cord-015021-pol2qm74	6668	21	has	have	VBZ
cord-015021-pol2qm74	6668	22	been	be	VBN
cord-015021-pol2qm74	6668	23	assessed	assess	VBN
cord-015021-pol2qm74	6668	24	by	by	IN
cord-015021-pol2qm74	6668	25	the	the	DT
cord-015021-pol2qm74	6668	26	spin	spin	NN
cord-015021-pol2qm74	6668	27	trapping	trapping	NN
cord-015021-pol2qm74	6668	28	technique	technique	NN
cord-015021-pol2qm74	6668	29	coupled	couple	VBN
cord-015021-pol2qm74	6668	30	to	to	IN
cord-015021-pol2qm74	6668	31	brain	brain	NN
cord-015021-pol2qm74	6668	32	microdialysis	microdialysis	NN
cord-015021-pol2qm74	6668	33	.	.	.
cord-015021-pol2qm74	6669	1	Esr	Esr	NNS
cord-015021-pol2qm74	6669	2	investigations	investigation	NNS
cord-015021-pol2qm74	6669	3	have	have	VBP
cord-015021-pol2qm74	6669	4	also	also	RB
cord-015021-pol2qm74	6669	5	been	be	VBN
cord-015021-pol2qm74	6669	6	conducted	conduct	VBN
cord-015021-pol2qm74	6669	7	to	to	TO
cord-015021-pol2qm74	6669	8	detect	detect	VB
cord-015021-pol2qm74	6669	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6669	10	-	-	HYPH
cord-015021-pol2qm74	6669	11	induced	induce	VBN
cord-015021-pol2qm74	6669	12	free	free	JJ
cord-015021-pol2qm74	6669	13	radical	radical	JJ
cord-015021-pol2qm74	6669	14	generation	generation	NN
cord-015021-pol2qm74	6669	15	in	in	IN
cord-015021-pol2qm74	6669	16	rat	rat	NN
cord-015021-pol2qm74	6669	17	or	or	CC
cord-015021-pol2qm74	6669	18	baboon	baboon	NN
cord-015021-pol2qm74	6669	19	liver	liver	NN
cord-015021-pol2qm74	6669	20	and	and	CC
cord-015021-pol2qm74	6669	21	 	 	_SP
cord-015021-pol2qm74	6669	22	Oxygen	oxygen	NN
cord-015021-pol2qm74	6669	23	free	free	JJ
cord-015021-pol2qm74	6669	24	radicals	radical	NNS
cord-015021-pol2qm74	6669	25	(	(	-LRB-
cord-015021-pol2qm74	6669	26	OFR	OFR	NNP
cord-015021-pol2qm74	6669	27	)	)	-RRB-
cord-015021-pol2qm74	6669	28	,	,	,
cord-015021-pol2qm74	6669	29	produced	produce	VBD
cord-015021-pol2qm74	6669	30	both	both	CC
cord-015021-pol2qm74	6669	31	at	at	IN
cord-015021-pol2qm74	6669	32	intra	intra	JJ
cord-015021-pol2qm74	6669	33	-	-	JJ
cord-015021-pol2qm74	6669	34	and	and	CC
cord-015021-pol2qm74	6669	35	extra	extra	JJ
cord-015021-pol2qm74	6669	36	-	-	JJ
cord-015021-pol2qm74	6669	37	cellular	cellular	JJ
cord-015021-pol2qm74	6669	38	levels	level	NNS
cord-015021-pol2qm74	6669	39	,	,	,
cord-015021-pol2qm74	6669	40	seem	seem	VBP
cord-015021-pol2qm74	6669	41	to	to	TO
cord-015021-pol2qm74	6669	42	play	play	VB
cord-015021-pol2qm74	6669	43	a	a	DT
cord-015021-pol2qm74	6669	44	major	major	JJ
cord-015021-pol2qm74	6669	45	role	role	NN
cord-015021-pol2qm74	6669	46	in	in	IN
cord-015021-pol2qm74	6669	47	the	the	DT
cord-015021-pol2qm74	6669	48	pathophysiology	pathophysiology	NN
cord-015021-pol2qm74	6669	49	of	of	IN
cord-015021-pol2qm74	6669	50	tissue	tissue	NN
cord-015021-pol2qm74	6669	51	injury	injury	NN
cord-015021-pol2qm74	6669	52	and	and	CC
cord-015021-pol2qm74	6669	53	organ	organ	NN
cord-015021-pol2qm74	6669	54	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6669	55	in	in	IN
cord-015021-pol2qm74	6669	56	sepsis	sepsis	NN
cord-015021-pol2qm74	6669	57	,	,	,
cord-015021-pol2qm74	6669	58	through	through	IN
cord-015021-pol2qm74	6669	59	induction	induction	NN
cord-015021-pol2qm74	6669	60	of	of	IN
cord-015021-pol2qm74	6669	61	lipid	lipid	NN
cord-015021-pol2qm74	6669	62	pemxidation	pemxidation	NN
cord-015021-pol2qm74	6669	63	in	in	IN
cord-015021-pol2qm74	6669	64	cell	cell	NN
cord-015021-pol2qm74	6669	65	membranes	membrane	NNS
cord-015021-pol2qm74	6669	66	.	.	.
cord-015021-pol2qm74	6670	1	Oxidative	oxidative	JJ
cord-015021-pol2qm74	6670	2	damage	damage	NN
cord-015021-pol2qm74	6670	3	can	can	MD
cord-015021-pol2qm74	6670	4	result	result	VB
cord-015021-pol2qm74	6670	5	both	both	DT
cord-015021-pol2qm74	6670	6	to	to	IN
cord-015021-pol2qm74	6670	7	an	an	DT
cord-015021-pol2qm74	6670	8	OFR	OFR	NNP
cord-015021-pol2qm74	6670	9	-	-	HYPH
cord-015021-pol2qm74	6670	10	overpmduction	overpmduction	NN
cord-015021-pol2qm74	6670	11	or	or	CC
cord-015021-pol2qm74	6670	12	to	to	IN
cord-015021-pol2qm74	6670	13	a	a	DT
cord-015021-pol2qm74	6670	14	depletion	depletion	NN
cord-015021-pol2qm74	6670	15	of	of	IN
cord-015021-pol2qm74	6670	16	endogenous	endogenous	JJ
cord-015021-pol2qm74	6670	17	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6670	18	defenses	defense	NNS
cord-015021-pol2qm74	6670	19	,	,	,
cord-015021-pol2qm74	6670	20	which	which	WDT
cord-015021-pol2qm74	6670	21	are	be	VBP
cord-015021-pol2qm74	6670	22	represented	represent	VBN
cord-015021-pol2qm74	6670	23	by	by	IN
cord-015021-pol2qm74	6670	24	scavenger	scavenger	NN
cord-015021-pol2qm74	6670	25	enzymes	enzyme	NNS
cord-015021-pol2qm74	6670	26	(	(	-LRB-
cord-015021-pol2qm74	6670	27	e.g.	e.g.	RB
cord-015021-pol2qm74	6670	28	SOD	SOD	NNP
cord-015021-pol2qm74	6670	29	)	)	-RRB-
cord-015021-pol2qm74	6670	30	,	,	,
cord-015021-pol2qm74	6670	31	hydrosoluble	hydrosoluble	JJ
cord-015021-pol2qm74	6670	32	and	and	CC
cord-015021-pol2qm74	6670	33	liposoluble	liposoluble	JJ
cord-015021-pol2qm74	6670	34	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6670	35	(	(	-LRB-
cord-015021-pol2qm74	6670	36	e.g.	e.g.	RB
cord-015021-pol2qm74	6670	37	ascorbate	ascorbate	NN
cord-015021-pol2qm74	6670	38	,	,	,
cord-015021-pol2qm74	6670	39	vitamin	vitamin	NN
cord-015021-pol2qm74	6670	40	E	e	NN
cord-015021-pol2qm74	6670	41	)	)	-RRB-
cord-015021-pol2qm74	6670	42	,	,	,
cord-015021-pol2qm74	6670	43	and	and	CC
cord-015021-pol2qm74	6670	44	other	other	JJ
cord-015021-pol2qm74	6670	45	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6670	46	such	such	JJ
cord-015021-pol2qm74	6670	47	as	as	IN
cord-015021-pol2qm74	6670	48	metal	metal	NN
cord-015021-pol2qm74	6670	49	-	-	HYPH
cord-015021-pol2qm74	6670	50	ion	ion	NN
cord-015021-pol2qm74	6670	51	sequestration	sequestration	NN
cord-015021-pol2qm74	6670	52	.	.	.
cord-015021-pol2qm74	6671	1	In	in	IN
cord-015021-pol2qm74	6671	2	animal	animal	NN
cord-015021-pol2qm74	6671	3	models	model	NNS
cord-015021-pol2qm74	6671	4	,	,	,
cord-015021-pol2qm74	6671	5	oxidative	oxidative	JJ
cord-015021-pol2qm74	6671	6	damage	damage	NN
cord-015021-pol2qm74	6671	7	has	have	VBZ
cord-015021-pol2qm74	6671	8	been	be	VBN
cord-015021-pol2qm74	6671	9	proved	prove	VBN
cord-015021-pol2qm74	6671	10	by	by	IN
cord-015021-pol2qm74	6671	11	detection	detection	NN
cord-015021-pol2qm74	6671	12	of	of	IN
cord-015021-pol2qm74	6671	13	increased	increase	VBN
cord-015021-pol2qm74	6671	14	levels	level	NNS
cord-015021-pol2qm74	6671	15	of	of	IN
cord-015021-pol2qm74	6671	16	lipoperoxidative	lipoperoxidative	JJ
cord-015021-pol2qm74	6671	17	products	product	NNS
cord-015021-pol2qm74	6671	18	,	,	,
cord-015021-pol2qm74	6671	19	and	and	CC
cord-015021-pol2qm74	6671	20	a	a	DT
cord-015021-pol2qm74	6671	21	depletion	depletion	NN
cord-015021-pol2qm74	6671	22	of	of	IN
cord-015021-pol2qm74	6671	23	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6671	24	defenses	defense	NNS
cord-015021-pol2qm74	6671	25	was	be	VBD
cord-015021-pol2qm74	6671	26	found	find	VBN
cord-015021-pol2qm74	6671	27	both	both	CC
cord-015021-pol2qm74	6671	28	in	in	IN
cord-015021-pol2qm74	6671	29	plasma	plasma	NN
cord-015021-pol2qm74	6671	30	and	and	CC
cord-015021-pol2qm74	6671	31	tissues	tissue	NNS
cord-015021-pol2qm74	6671	32	.	.	.
cord-015021-pol2qm74	6672	1	In	in	IN
cord-015021-pol2qm74	6672	2	the	the	DT
cord-015021-pol2qm74	6672	3	few	few	JJ
cord-015021-pol2qm74	6672	4	clinical	clinical	JJ
cord-015021-pol2qm74	6672	5	studies	study	NNS
cord-015021-pol2qm74	6672	6	a	a	DT
cord-015021-pol2qm74	6672	7	similar	similar	JJ
cord-015021-pol2qm74	6672	8	results	result	NNS
cord-015021-pol2qm74	6672	9	have	have	VBP
cord-015021-pol2qm74	6672	10	been	be	VBN
cord-015021-pol2qm74	6672	11	reported	report	VBN
cord-015021-pol2qm74	6672	12	,	,	,
cord-015021-pol2qm74	6672	13	and	and	CC
cord-015021-pol2qm74	6672	14	oxidative	oxidative	JJ
cord-015021-pol2qm74	6672	15	damage	damage	NN
cord-015021-pol2qm74	6672	16	appears	appear	VBZ
cord-015021-pol2qm74	6672	17	to	to	TO
cord-015021-pol2qm74	6672	18	correlate	correlate	VB
cord-015021-pol2qm74	6672	19	with	with	IN
cord-015021-pol2qm74	6672	20	DIC	DIC	NNP
cord-015021-pol2qm74	6672	21	,	,	,
cord-015021-pol2qm74	6672	22	with	with	IN
cord-015021-pol2qm74	6672	23	organ	organ	NN
cord-015021-pol2qm74	6672	24	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6672	25	and	and	CC
cord-015021-pol2qm74	6672	26	with	with	IN
cord-015021-pol2qm74	6672	27	red	red	JJ
cord-015021-pol2qm74	6672	28	blood	blood	NN
cord-015021-pol2qm74	6672	29	cell	cell	NN
cord-015021-pol2qm74	6672	30	deformability	deformability	NN
cord-015021-pol2qm74	6672	31	.	.	.
cord-015021-pol2qm74	6673	1	In	in	IN
cord-015021-pol2qm74	6673	2	a	a	DT
cord-015021-pol2qm74	6673	3	group	group	NN
cord-015021-pol2qm74	6673	4	of	of	IN
cord-015021-pol2qm74	6673	5	critically	critically	RB
cord-015021-pol2qm74	6673	6	ill	ill	JJ
cord-015021-pol2qm74	6673	7	septic	septic	JJ
cord-015021-pol2qm74	6673	8	patients	patient	NNS
cord-015021-pol2qm74	6673	9	we	-PRON-	PRP
cord-015021-pol2qm74	6673	10	found	find	VBD
cord-015021-pol2qm74	6673	11	increased	increase	VBN
cord-015021-pol2qm74	6673	12	levels	level	NNS
cord-015021-pol2qm74	6673	13	of	of	IN
cord-015021-pol2qm74	6673	14	conjugated	conjugated	JJ
cord-015021-pol2qm74	6673	15	dienes	diene	NNS
cord-015021-pol2qm74	6673	16	(	(	-LRB-
cord-015021-pol2qm74	6673	17	CD	CD	NNP
cord-015021-pol2qm74	6673	18	)	)	-RRB-
cord-015021-pol2qm74	6673	19	(	(	-LRB-
cord-015021-pol2qm74	6673	20	bioproducts	bioproduct	NNS
cord-015021-pol2qm74	6673	21	of	of	IN
cord-015021-pol2qm74	6673	22	lipoperoxidation	lipoperoxidation	NNP
cord-015021-pol2qm74	6673	23	)	)	-RRB-
cord-015021-pol2qm74	6673	24	and	and	CC
cord-015021-pol2qm74	6673	25	decreased	decrease	VBD
cord-015021-pol2qm74	6673	26	plasma	plasma	NN
cord-015021-pol2qm74	6673	27	levels	level	NNS
cord-015021-pol2qm74	6673	28	of	of	IN
cord-015021-pol2qm74	6673	29	alpha	alpha	NN
cord-015021-pol2qm74	6673	30	-	-	HYPH
cord-015021-pol2qm74	6673	31	tocopherol	tocopherol	NN
cord-015021-pol2qm74	6673	32	and	and	CC
cord-015021-pol2qm74	6673	33	coenzyme	coenzyme	NN
cord-015021-pol2qm74	6673	34	Qlo	Qlo	NNP
cord-015021-pol2qm74	6673	35	(	(	-LRB-
cord-015021-pol2qm74	6673	36	CoQI0)(endogenous	coqi0)(endogenous	JJ
cord-015021-pol2qm74	6673	37	liposoluble	liposoluble	NNP
cord-015021-pol2qm74	6673	38	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6673	39	)	)	-RRB-
cord-015021-pol2qm74	6673	40	.	.	.
cord-015021-pol2qm74	6674	1	A	a	DT
cord-015021-pol2qm74	6674	2	relationship	relationship	NN
cord-015021-pol2qm74	6674	3	between	between	IN
cord-015021-pol2qm74	6674	4	CD	cd	NN
cord-015021-pol2qm74	6674	5	and	and	CC
cord-015021-pol2qm74	6674	6	uric	uric	NN
cord-015021-pol2qm74	6674	7	acid	acid	NN
cord-015021-pol2qm74	6674	8	(	(	-LRB-
cord-015021-pol2qm74	6674	9	p<0.004	p<0.004	CD
cord-015021-pol2qm74	6674	10	)	)	-RRB-
cord-015021-pol2qm74	6674	11	was	be	VBD
cord-015021-pol2qm74	6674	12	found	find	VBN
cord-015021-pol2qm74	6674	13	,	,	,
cord-015021-pol2qm74	6674	14	may	may	MD
cord-015021-pol2qm74	6674	15	be	be	VB
cord-015021-pol2qm74	6674	16	related	relate	VBN
cord-015021-pol2qm74	6674	17	to	to	IN
cord-015021-pol2qm74	6674	18	xantine	xantine	NN
cord-015021-pol2qm74	6674	19	-	-	HYPH
cord-015021-pol2qm74	6674	20	dehydmgenase	dehydmgenase	NNP
cord-015021-pol2qm74	6674	21	to	to	IN
cord-015021-pol2qm74	6674	22	xantine	xantine	NN
cord-015021-pol2qm74	6674	23	-	-	HYPH
cord-015021-pol2qm74	6674	24	oxidase	oxidase	JJ
cord-015021-pol2qm74	6674	25	conversion	conversion	NN
cord-015021-pol2qm74	6674	26	.	.	.
cord-015021-pol2qm74	6675	1	Antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6675	2	depletion	depletion	NN
cord-015021-pol2qm74	6675	3	is	be	VBZ
cord-015021-pol2qm74	6675	4	due	due	JJ
cord-015021-pol2qm74	6675	5	both	both	DT
cord-015021-pol2qm74	6675	6	to	to	IN
cord-015021-pol2qm74	6675	7	overconsumption	overconsumption	NN
cord-015021-pol2qm74	6675	8	and	and	CC
cord-015021-pol2qm74	6675	9	to	to	IN
cord-015021-pol2qm74	6675	10	a	a	DT
cord-015021-pol2qm74	6675	11	nutritional	nutritional	JJ
cord-015021-pol2qm74	6675	12	deficiency	deficiency	NN
cord-015021-pol2qm74	6675	13	,	,	,
cord-015021-pol2qm74	6675	14	even	even	RB
cord-015021-pol2qm74	6675	15	if	if	IN
cord-015021-pol2qm74	6675	16	a	a	DT
cord-015021-pol2qm74	6675	17	reduced	reduce	VBN
cord-015021-pol2qm74	6675	18	synthesis	synthesis	NN
cord-015021-pol2qm74	6675	19	can	can	MD
cord-015021-pol2qm74	6675	20	also	also	RB
cord-015021-pol2qm74	6675	21	be	be	VB
cord-015021-pol2qm74	6675	22	present	present	JJ
cord-015021-pol2qm74	6675	23	.	.	.
cord-015021-pol2qm74	6676	1	In	in	IN
cord-015021-pol2qm74	6676	2	fact	fact	NN
cord-015021-pol2qm74	6676	3	one	one	CD
cord-015021-pol2qm74	6676	4	more	more	JJR
cord-015021-pol2qm74	6676	5	relationship	relationship	NN
cord-015021-pol2qm74	6676	6	between	between	IN
cord-015021-pol2qm74	6676	7	CoQI0	CoQI0	NNP
cord-015021-pol2qm74	6676	8	and	and	CC
cord-015021-pol2qm74	6676	9	plasma	plasma	NN
cord-015021-pol2qm74	6676	10	cholesterol	cholesterol	NN
cord-015021-pol2qm74	6676	11	(	(	-LRB-
cord-015021-pol2qm74	6676	12	p<0.0005	p<0.0005	NN
cord-015021-pol2qm74	6676	13	)	)	-RRB-
cord-015021-pol2qm74	6676	14	demonstrates	demonstrate	VBZ
cord-015021-pol2qm74	6676	15	the	the	DT
cord-015021-pol2qm74	6676	16	commun	commun	NNP
cord-015021-pol2qm74	6676	17	hepatic	hepatic	JJ
cord-015021-pol2qm74	6676	18	biosynthetic	biosynthetic	JJ
cord-015021-pol2qm74	6676	19	defect	defect	NN
cord-015021-pol2qm74	6676	20	.	.	.
cord-015021-pol2qm74	6677	1	Is	be	VBZ
cord-015021-pol2qm74	6677	2	there	there	EX
cord-015021-pol2qm74	6677	3	any	any	DT
cord-015021-pol2qm74	6677	4	role	role	NN
cord-015021-pol2qm74	6677	5	for	for	IN
cord-015021-pol2qm74	6677	6	antioxidative	antioxidative	JJ
cord-015021-pol2qm74	6677	7	therapy	therapy	NN
cord-015021-pol2qm74	6677	8	in	in	IN
cord-015021-pol2qm74	6677	9	sepsis	sepsis	NN
cord-015021-pol2qm74	6677	10	?	?	.
cord-015021-pol2qm74	6678	1	Can	Can	MD
cord-015021-pol2qm74	6678	2	it	-PRON-	PRP
cord-015021-pol2qm74	6678	3	achives	achive	VBZ
cord-015021-pol2qm74	6678	4	a	a	DT
cord-015021-pol2qm74	6678	5	significant	significant	JJ
cord-015021-pol2qm74	6678	6	improvement	improvement	NN
cord-015021-pol2qm74	6678	7	in	in	IN
cord-015021-pol2qm74	6678	8	the	the	DT
cord-015021-pol2qm74	6678	9	septic	septic	JJ
cord-015021-pol2qm74	6678	10	course	course	NN
cord-015021-pol2qm74	6678	11	,	,	,
cord-015021-pol2qm74	6678	12	organ	organ	NN
cord-015021-pol2qm74	6678	13	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6678	14	,	,	,
cord-015021-pol2qm74	6678	15	and	and	CC
cord-015021-pol2qm74	6678	16	final	final	JJ
cord-015021-pol2qm74	6678	17	outcome	outcome	NN
cord-015021-pol2qm74	6678	18	?	?	.
cord-015021-pol2qm74	6679	1	Several	several	JJ
cord-015021-pol2qm74	6679	2	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6679	3	drugs	drug	NNS
cord-015021-pol2qm74	6679	4	,	,	,
cord-015021-pol2qm74	6679	5	have	have	VBP
cord-015021-pol2qm74	6679	6	been	be	VBN
cord-015021-pol2qm74	6679	7	evaluated	evaluate	VBN
cord-015021-pol2qm74	6679	8	in	in	IN
cord-015021-pol2qm74	6679	9	experimental	experimental	JJ
cord-015021-pol2qm74	6679	10	and	and	CC
cord-015021-pol2qm74	6679	11	clinical	clinical	JJ
cord-015021-pol2qm74	6679	12	sepsis	sepsis	NN
cord-015021-pol2qm74	6679	13	:	:	:
cord-015021-pol2qm74	6679	14	scavenger	scavenger	NN
cord-015021-pol2qm74	6679	15	enzymes	enzyme	NNS
cord-015021-pol2qm74	6679	16	,	,	,
cord-015021-pol2qm74	6679	17	natural	natural	JJ
cord-015021-pol2qm74	6679	18	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6679	19	,	,	,
cord-015021-pol2qm74	6679	20	alloporinol	alloporinol	NN
cord-015021-pol2qm74	6679	21	,	,	,
cord-015021-pol2qm74	6679	22	21-aminosteroids	21-aminosteroids	CD
cord-015021-pol2qm74	6679	23	or	or	CC
cord-015021-pol2qm74	6679	24	lazaroids	lazaroid	NNS
cord-015021-pol2qm74	6679	25	,	,	,
cord-015021-pol2qm74	6679	26	have	have	VBP
cord-015021-pol2qm74	6679	27	been	be	VBN
cord-015021-pol2qm74	6679	28	proved	prove	VBN
cord-015021-pol2qm74	6679	29	to	to	TO
cord-015021-pol2qm74	6679	30	reduce	reduce	VB
cord-015021-pol2qm74	6679	31	lipopemxidative	lipopemxidative	JJ
cord-015021-pol2qm74	6679	32	damage	damage	NN
cord-015021-pol2qm74	6679	33	,	,	,
cord-015021-pol2qm74	6679	34	to	to	TO
cord-015021-pol2qm74	6679	35	protect	protect	VB
cord-015021-pol2qm74	6679	36	organ	organ	NN
cord-015021-pol2qm74	6679	37	dysfunction	dysfunction	NN
cord-015021-pol2qm74	6679	38	,	,	,
cord-015021-pol2qm74	6679	39	and	and	CC
cord-015021-pol2qm74	6679	40	in	in	IN
cord-015021-pol2qm74	6679	41	some	some	DT
cord-015021-pol2qm74	6679	42	cases	case	NNS
cord-015021-pol2qm74	6679	43	to	to	TO
cord-015021-pol2qm74	6679	44	improve	improve	VB
cord-015021-pol2qm74	6679	45	survival	survival	NN
cord-015021-pol2qm74	6679	46	.	.	.
cord-015021-pol2qm74	6680	1	Several	several	JJ
cord-015021-pol2qm74	6680	2	questions	question	NNS
cord-015021-pol2qm74	6680	3	must	must	MD
cord-015021-pol2qm74	6680	4	be	be	VB
cord-015021-pol2qm74	6680	5	addressed	address	VBN
cord-015021-pol2qm74	6680	6	in	in	IN
cord-015021-pol2qm74	6680	7	evaluating	evaluate	VBG
cord-015021-pol2qm74	6680	8	safety	safety	NN
cord-015021-pol2qm74	6680	9	and	and	CC
cord-015021-pol2qm74	6680	10	utility	utility	NN
cord-015021-pol2qm74	6680	11	of	of	IN
cord-015021-pol2qm74	6680	12	antioxidative	antioxidative	JJ
cord-015021-pol2qm74	6680	13	therapy	therapy	NN
cord-015021-pol2qm74	6680	14	.	.	.
cord-015021-pol2qm74	6681	1	More	more	RBR
cord-015021-pol2qm74	6681	2	specific	specific	JJ
cord-015021-pol2qm74	6681	3	and	and	CC
cord-015021-pol2qm74	6681	4	standardized	standardized	JJ
cord-015021-pol2qm74	6681	5	methods	method	NNS
cord-015021-pol2qm74	6681	6	must	must	MD
cord-015021-pol2qm74	6681	7	be	be	VB
cord-015021-pol2qm74	6681	8	applied	apply	VBN
cord-015021-pol2qm74	6681	9	to	to	TO
cord-015021-pol2qm74	6681	10	detect	detect	VB
cord-015021-pol2qm74	6681	11	and	and	CC
cord-015021-pol2qm74	6681	12	quantify	quantify	VB
cord-015021-pol2qm74	6681	13	the	the	DT
cord-015021-pol2qm74	6681	14	lipoperoxidative	lipoperoxidative	JJ
cord-015021-pol2qm74	6681	15	damage	damage	NN
cord-015021-pol2qm74	6681	16	.	.	.
cord-015021-pol2qm74	6682	1	Antioxidant	antioxidant	NN
cord-015021-pol2qm74	6682	2	drags	drag	VBZ
cord-015021-pol2qm74	6682	3	must	must	MD
cord-015021-pol2qm74	6682	4	act	act	VB
cord-015021-pol2qm74	6682	5	selectively	selectively	RB
cord-015021-pol2qm74	6682	6	on	on	IN
cord-015021-pol2qm74	6682	7	OFR	ofr	NN
cord-015021-pol2qm74	6682	8	-	-	HYPH
cord-015021-pol2qm74	6682	9	production	production	NN
cord-015021-pol2qm74	6682	10	,	,	,
cord-015021-pol2qm74	6682	11	without	without	IN
cord-015021-pol2qm74	6682	12	interference	interference	NN
cord-015021-pol2qm74	6682	13	with	with	IN
cord-015021-pol2qm74	6682	14	other	other	JJ
cord-015021-pol2qm74	6682	15	than	than	IN
cord-015021-pol2qm74	6683	1	that	that	WDT
cord-015021-pol2qm74	6683	2	are	be	VBP
cord-015021-pol2qm74	6683	3	beneficial	beneficial	JJ
cord-015021-pol2qm74	6683	4	for	for	IN
cord-015021-pol2qm74	6683	5	the	the	DT
cord-015021-pol2qm74	6683	6	organism	organism	NN
cord-015021-pol2qm74	6683	7	.	.	.
cord-015021-pol2qm74	6684	1	Antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6684	2	must	must	MD
cord-015021-pol2qm74	6684	3	be	be	VB
cord-015021-pol2qm74	6684	4	able	able	JJ
cord-015021-pol2qm74	6684	5	to	to	TO
cord-015021-pol2qm74	6684	6	achive	achive	VB
cord-015021-pol2qm74	6684	7	in	in	IN
cord-015021-pol2qm74	6684	8	adequate	adequate	JJ
cord-015021-pol2qm74	6684	9	amount	amount	NN
cord-015021-pol2qm74	6684	10	the	the	DT
cord-015021-pol2qm74	6684	11	tissue	tissue	NN
cord-015021-pol2qm74	6684	12	or	or	CC
cord-015021-pol2qm74	6684	13	cellular	cellular	JJ
cord-015021-pol2qm74	6684	14	compartment	compartment	NN
cord-015021-pol2qm74	6684	15	where	where	WRB
cord-015021-pol2qm74	6684	16	their	-PRON-	PRP$
cord-015021-pol2qm74	6684	17	action	action	NN
cord-015021-pol2qm74	6684	18	is	be	VBZ
cord-015021-pol2qm74	6684	19	required	require	VBN
cord-015021-pol2qm74	6684	20	.	.	.
cord-015021-pol2qm74	6685	1	Many	many	JJ
cord-015021-pol2qm74	6685	2	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6685	3	have	have	VBP
cord-015021-pol2qm74	6685	4	also	also	RB
cord-015021-pol2qm74	6685	5	a	a	DT
cord-015021-pol2qm74	6685	6	pro	pro	JJ
cord-015021-pol2qm74	6685	7	-	-	JJ
cord-015021-pol2qm74	6685	8	oxidative	oxidative	JJ
cord-015021-pol2qm74	6685	9	effect	effect	NN
cord-015021-pol2qm74	6685	10	which	which	WDT
cord-015021-pol2qm74	6685	11	can	can	MD
cord-015021-pol2qm74	6685	12	he	-PRON-	PRP
cord-015021-pol2qm74	6685	13	detrimental	detrimental	VB
cord-015021-pol2qm74	6685	14	in	in	IN
cord-015021-pol2qm74	6685	15	some	some	DT
cord-015021-pol2qm74	6685	16	conditions	condition	NNS
cord-015021-pol2qm74	6685	17	.	.	.
cord-015021-pol2qm74	6686	1	The	the	DT
cord-015021-pol2qm74	6686	2	timing	timing	NN
cord-015021-pol2qm74	6686	3	of	of	IN
cord-015021-pol2qm74	6686	4	administration	administration	NN
cord-015021-pol2qm74	6686	5	,	,	,
cord-015021-pol2qm74	6686	6	the	the	DT
cord-015021-pol2qm74	6686	7	dosage	dosage	NN
cord-015021-pol2qm74	6686	8	used	use	VBN
cord-015021-pol2qm74	6686	9	and	and	CC
cord-015021-pol2qm74	6686	10	the	the	DT
cord-015021-pol2qm74	6686	11	association	association	NN
cord-015021-pol2qm74	6686	12	wih	wih	IN
cord-015021-pol2qm74	6686	13	others	other	NNS
cord-015021-pol2qm74	6686	14	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6686	15	drugs	drug	NNS
cord-015021-pol2qm74	6686	16	must	must	MD
cord-015021-pol2qm74	6686	17	be	be	VB
cord-015021-pol2qm74	6686	18	defined	define	VBN
cord-015021-pol2qm74	6686	19	.	.	.
cord-015021-pol2qm74	6687	1	Nutrition	nutrition	NN
cord-015021-pol2qm74	6687	2	plays	play	VBZ
cord-015021-pol2qm74	6687	3	an	an	DT
cord-015021-pol2qm74	6687	4	important	important	JJ
cord-015021-pol2qm74	6687	5	role	role	NN
cord-015021-pol2qm74	6687	6	as	as	IN
cord-015021-pol2qm74	6687	7	antioxidative	antioxidative	JJ
cord-015021-pol2qm74	6687	8	therapy	therapy	NN
cord-015021-pol2qm74	6687	9	,	,	,
cord-015021-pol2qm74	6687	10	since	since	IN
cord-015021-pol2qm74	6687	11	it	-PRON-	PRP
cord-015021-pol2qm74	6687	12	supplies	supply	VBZ
cord-015021-pol2qm74	6687	13	all	all	DT
cord-015021-pol2qm74	6687	14	compounds	compound	NNS
cord-015021-pol2qm74	6687	15	needed	need	VBN
cord-015021-pol2qm74	6687	16	to	to	TO
cord-015021-pol2qm74	6687	17	maintain	maintain	VB
cord-015021-pol2qm74	6687	18	adequately	adequately	RB
cord-015021-pol2qm74	6687	19	levels	level	NNS
cord-015021-pol2qm74	6687	20	of	of	IN
cord-015021-pol2qm74	6687	21	endogenous	endogenous	JJ
cord-015021-pol2qm74	6687	22	antioxidant	antioxidant	NN
cord-015021-pol2qm74	6687	23	or	or	CC
cord-015021-pol2qm74	6687	24	to	to	TO
cord-015021-pol2qm74	6687	25	support	support	VB
cord-015021-pol2qm74	6687	26	their	-PRON-	PRP$
cord-015021-pol2qm74	6687	27	synthesis	synthesis	NN
cord-015021-pol2qm74	6687	28	.	.	.
cord-015021-pol2qm74	6688	1	Thiobarbituric	thiobarbituric	JJ
cord-015021-pol2qm74	6688	2	acid	acid	NN
cord-015021-pol2qm74	6688	3	reactive	reactive	JJ
cord-015021-pol2qm74	6688	4	substances	substance	NNS
cord-015021-pol2qm74	6689	1	(	(	-LRB-
cord-015021-pol2qm74	6689	2	TBARS	TBARS	NNP
cord-015021-pol2qm74	6689	3	)	)	-RRB-
cord-015021-pol2qm74	6689	4	concentration	concentration	NN
cord-015021-pol2qm74	6689	5	in	in	IN
cord-015021-pol2qm74	6689	6	serum	serum	NN
cord-015021-pol2qm74	6689	7	has	have	VBZ
cord-015021-pol2qm74	6689	8	been	be	VBN
cord-015021-pol2qm74	6689	9	determined	determine	VBN
cord-015021-pol2qm74	6689	10	in	in	IN
cord-015021-pol2qm74	6689	11	a	a	DT
cord-015021-pol2qm74	6689	12	large	large	JJ
cord-015021-pol2qm74	6689	13	population	population	NN
cord-015021-pol2qm74	6689	14	of	of	IN
cord-015021-pol2qm74	6689	15	healthy	healthy	JJ
cord-015021-pol2qm74	6689	16	subjects	subject	NNS
cord-015021-pol2qm74	6689	17	and	and	CC
cord-015021-pol2qm74	6689	18	in	in	IN
cord-015021-pol2qm74	6689	19	patients	patient	NNS
cord-015021-pol2qm74	6689	20	suffering	suffer	VBG
cord-015021-pol2qm74	6689	21	acute	acute	JJ
cord-015021-pol2qm74	6689	22	hepatitis	hepatitis	NN
cord-015021-pol2qm74	6689	23	and	and	CC
cord-015021-pol2qm74	6689	24	chronic	chronic	JJ
cord-015021-pol2qm74	6689	25	cases	case	NNS
cord-015021-pol2qm74	6689	26	of	of	IN
cord-015021-pol2qm74	6689	27	hepatitis	hepatitis	NN
cord-015021-pol2qm74	6689	28	C	C	NNP
cord-015021-pol2qm74	6689	29	,	,	,
cord-015021-pol2qm74	6689	30	as	as	RB
cord-015021-pol2qm74	6689	31	well	well	RB
cord-015021-pol2qm74	6689	32	as	as	IN
cord-015021-pol2qm74	6689	33	several	several	JJ
cord-015021-pol2qm74	6689	34	other	other	JJ
cord-015021-pol2qm74	6689	35	processes	process	NNS
cord-015021-pol2qm74	6689	36	.	.	.
cord-015021-pol2qm74	6690	1	The	the	DT
cord-015021-pol2qm74	6690	2	correlation	correlation	NN
cord-015021-pol2qm74	6690	3	with	with	IN
cord-015021-pol2qm74	6690	4	different	different	JJ
cord-015021-pol2qm74	6690	5	physiological	physiological	JJ
cord-015021-pol2qm74	6690	6	and	and	CC
cord-015021-pol2qm74	6690	7	clinical	clinical	JJ
cord-015021-pol2qm74	6690	8	parameters	parameter	NNS
cord-015021-pol2qm74	6690	9	in	in	IN
cord-015021-pol2qm74	6690	10	these	these	DT
cord-015021-pol2qm74	6690	11	populations	population	NNS
cord-015021-pol2qm74	6690	12	is	be	VBZ
cord-015021-pol2qm74	6690	13	also	also	RB
cord-015021-pol2qm74	6690	14	presented	present	VBN
cord-015021-pol2qm74	6690	15	.	.	.
cord-015021-pol2qm74	6691	1	Treatment	treatment	NN
cord-015021-pol2qm74	6691	2	with	with	IN
cord-015021-pol2qm74	6691	3	interferon	interferon	NN
cord-015021-pol2qm74	6691	4	of	of	IN
cord-015021-pol2qm74	6691	5	the	the	DT
cord-015021-pol2qm74	6691	6	chronic	chronic	JJ
cord-015021-pol2qm74	6691	7	active	active	JJ
cord-015021-pol2qm74	6691	8	hepatitis	hepatitis	NN
cord-015021-pol2qm74	6691	9	C	C	NNP
cord-015021-pol2qm74	6691	10	patients	patient	NNS
cord-015021-pol2qm74	6691	11	,	,	,
cord-015021-pol2qm74	6691	12	5x10	5x10	CD
cord-015021-pol2qm74	6691	13	U	U	NNP
cord-015021-pol2qm74	6691	14	three	three	CD
cord-015021-pol2qm74	6691	15	times	time	NNS
cord-015021-pol2qm74	6691	16	a	a	DT
cord-015021-pol2qm74	6691	17	week	week	NN
cord-015021-pol2qm74	6691	18	during	during	IN
cord-015021-pol2qm74	6691	19	two	two	CD
cord-015021-pol2qm74	6691	20	months	month	NNS
cord-015021-pol2qm74	6691	21	,	,	,
cord-015021-pol2qm74	6691	22	led	lead	VBN
cord-015021-pol2qm74	6691	23	in	in	IN
cord-015021-pol2qm74	6691	24	those	those	DT
cord-015021-pol2qm74	6691	25	patients	patient	NNS
cord-015021-pol2qm74	6691	26	whose	whose	WP$
cord-015021-pol2qm74	6691	27	SGPT	SGPT	NNP
cord-015021-pol2qm74	6691	28	activity	activity	NN
cord-015021-pol2qm74	6691	29	normalized	normalize	VBN
cord-015021-pol2qm74	6691	30	in	in	IN
cord-015021-pol2qm74	6691	31	serum	serum	NN
cord-015021-pol2qm74	6691	32	,	,	,
cord-015021-pol2qm74	6691	33	to	to	IN
cord-015021-pol2qm74	6691	34	a	a	DT
cord-015021-pol2qm74	6691	35	concomitant	concomitant	JJ
cord-015021-pol2qm74	6691	36	decrease	decrease	NN
cord-015021-pol2qm74	6691	37	in	in	IN
cord-015021-pol2qm74	6691	38	serum	serum	NN
cord-015021-pol2qm74	6691	39	TBARS	tbars	NN
cord-015021-pol2qm74	6691	40	content	content	NN
cord-015021-pol2qm74	6691	41	.	.	.
cord-015021-pol2qm74	6692	1	The	the	DT
cord-015021-pol2qm74	6692	2	possible	possible	JJ
cord-015021-pol2qm74	6692	3	theoretical	theoretical	JJ
cord-015021-pol2qm74	6692	4	involvement	involvement	NN
cord-015021-pol2qm74	6692	5	of	of	IN
cord-015021-pol2qm74	6692	6	peroxidation	peroxidation	NN
cord-015021-pol2qm74	6692	7	and	and	CC
cord-015021-pol2qm74	6692	8	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6692	9	in	in	IN
cord-015021-pol2qm74	6692	10	this	this	DT
cord-015021-pol2qm74	6692	11	beneficial	beneficial	JJ
cord-015021-pol2qm74	6692	12	effect	effect	NN
cord-015021-pol2qm74	6692	13	of	of	IN
cord-015021-pol2qm74	6692	14	i	i	PRP
cord-015021-pol2qm74	6692	15	~	~	NFP
cord-015021-pol2qm74	6692	16	terferon	terferon	NNP
cord-015021-pol2qm74	6692	17	in	in	IN
cord-015021-pol2qm74	6692	18	hepatitis	hepatitis	NN
cord-015021-pol2qm74	6692	19	C	C	NNP
cord-015021-pol2qm74	6692	20	patients	patient	NNS
cord-015021-pol2qm74	6692	21	is	be	VBZ
cord-015021-pol2qm74	6692	22	discussed	discuss	VBN
cord-015021-pol2qm74	6692	23	.	.	.
cord-015021-pol2qm74	6693	1	The	the	DT
cord-015021-pol2qm74	6693	2	results	result	NNS
cord-015021-pol2qm74	6693	3	presented	present	VBN
cord-015021-pol2qm74	6693	4	confirm	confirm	VBP
cord-015021-pol2qm74	6693	5	the	the	DT
cord-015021-pol2qm74	6693	6	value	value	NN
cord-015021-pol2qm74	6693	7	of	of	IN
cord-015021-pol2qm74	6693	8	TBARS	TBARS	NNP
cord-015021-pol2qm74	6693	9	as	as	IN
cord-015021-pol2qm74	6693	10	laboratory	laboratory	NN
cord-015021-pol2qm74	6693	11	test	test	NN
cord-015021-pol2qm74	6693	12	in	in	IN
cord-015021-pol2qm74	6693	13	the	the	DT
cord-015021-pol2qm74	6693	14	management	management	NN
cord-015021-pol2qm74	6693	15	of	of	IN
cord-015021-pol2qm74	6693	16	disease	disease	NN
cord-015021-pol2qm74	6693	17	and	and	CC
cord-015021-pol2qm74	6693	18	as	as	IN
cord-015021-pol2qm74	6693	19	a	a	DT
cord-015021-pol2qm74	6693	20	useful	useful	JJ
cord-015021-pol2qm74	6693	21	tool	tool	NN
cord-015021-pol2qm74	6693	22	for	for	IN
cord-015021-pol2qm74	6693	23	the	the	DT
cord-015021-pol2qm74	6693	24	study	study	NN
cord-015021-pol2qm74	6693	25	of	of	IN
cord-015021-pol2qm74	6693	26	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	6693	27	and/or	and/or	CC
cord-015021-pol2qm74	6693	28	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6693	29	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6693	30	.	.	.
cord-015021-pol2qm74	6694	1	4-Hydroxyalkenals	4-hydroxyalkenals	CD
cord-015021-pol2qm74	6694	2	are	be	VBP
cord-015021-pol2qm74	6694	3	among	among	IN
cord-015021-pol2qm74	6694	4	the	the	DT
cord-015021-pol2qm74	6694	5	different	different	JJ
cord-015021-pol2qm74	6694	6	substances	substance	NNS
cord-015021-pol2qm74	6694	7	measured	measure	VBN
cord-015021-pol2qm74	6694	8	by	by	IN
cord-015021-pol2qm74	6694	9	the	the	DT
cord-015021-pol2qm74	6694	10	TBARS	TBARS	NNP
cord-015021-pol2qm74	6694	11	assay	assay	NN
cord-015021-pol2qm74	6694	12	.	.	.
cord-015021-pol2qm74	6695	1	These	these	DT
cord-015021-pol2qm74	6695	2	compounds	compound	NNS
cord-015021-pol2qm74	6695	3	show	show	VBP
cord-015021-pol2qm74	6695	4	several	several	JJ
cord-015021-pol2qm74	6695	5	biological	biological	JJ
cord-015021-pol2qm74	6695	6	effects	effect	NNS
cord-015021-pol2qm74	6695	7	that	that	WDT
cord-015021-pol2qm74	6695	8	have	have	VBP
cord-015021-pol2qm74	6695	9	been	be	VBN
cord-015021-pol2qm74	6695	10	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	6695	11	mainly	mainly	RB
cord-015021-pol2qm74	6695	12	in	in	IN
cord-015021-pol2qm74	6695	13	different	different	JJ
cord-015021-pol2qm74	6695	14	experimental	experimental	JJ
cord-015021-pol2qm74	6695	15	models	model	NNS
cord-015021-pol2qm74	6695	16	.	.	.
cord-015021-pol2qm74	6696	1	We	-PRON-	PRP
cord-015021-pol2qm74	6696	2	have	have	VBP
cord-015021-pol2qm74	6696	3	studied	study	VBN
cord-015021-pol2qm74	6696	4	the	the	DT
cord-015021-pol2qm74	6696	5	capacity	capacity	NN
cord-015021-pol2qm74	6696	6	of	of	IN
cord-015021-pol2qm74	6696	7	different	different	JJ
cord-015021-pol2qm74	6696	8	tissues	tissue	NNS
cord-015021-pol2qm74	6696	9	to	to	TO
cord-015021-pol2qm74	6696	10	conjugate	conjugate	VB
cord-015021-pol2qm74	6696	11	these	these	DT
cord-015021-pol2qm74	6696	12	compounds	compound	NNS
cord-015021-pol2qm74	6696	13	 	 	_SP
cord-015021-pol2qm74	6696	14	Patients	patient	NNS
cord-015021-pol2qm74	6696	15	surviving	survive	VBG
cord-015021-pol2qm74	6696	16	the	the	DT
cord-015021-pol2qm74	6696	17	initial	initial	JJ
cord-015021-pol2qm74	6696	18	subarachnoid	subarachnoid	NN
cord-015021-pol2qm74	6696	19	hemorrhage	hemorrhage	NN
cord-015021-pol2qm74	6696	20	(	(	-LRB-
cord-015021-pol2qm74	6696	21	SAH	SAH	NNP
cord-015021-pol2qm74	6696	22	)	)	-RRB-
cord-015021-pol2qm74	6696	23	from	from	IN
cord-015021-pol2qm74	6696	24	a	a	DT
cord-015021-pol2qm74	6696	25	ruptured	ruptured	NN
cord-015021-pol2qm74	6696	26	in	in	IN
cord-015021-pol2qm74	6696	27	~	~	CD
cord-015021-pol2qm74	6696	28	raeranial	raeranial	JJ
cord-015021-pol2qm74	6696	29	aneurysm	aneurysm	NNP
cord-015021-pol2qm74	6696	30	are	be	VBP
cord-015021-pol2qm74	6696	31	prone	prone	JJ
cord-015021-pol2qm74	6696	32	to	to	TO
cord-015021-pol2qm74	6696	33	develop	develop	VB
cord-015021-pol2qm74	6696	34	cerebra	cerebra	NN
cord-015021-pol2qm74	6696	35	]	]	-RRB-
cord-015021-pol2qm74	6696	36	ischemia	ischemia	NN
cord-015021-pol2qm74	6696	37	from	from	IN
cord-015021-pol2qm74	6696	38	vasospasm	vasospasm	NN
cord-015021-pol2qm74	6696	39	which	which	WDT
cord-015021-pol2qm74	6696	40	is	be	VBZ
cord-015021-pol2qm74	6696	41	associated	associate	VBN
cord-015021-pol2qm74	6696	42	with	with	IN
cord-015021-pol2qm74	6696	43	significant	significant	JJ
cord-015021-pol2qm74	6696	44	morbidity	morbidity	NN
cord-015021-pol2qm74	6696	45	and	and	CC
cord-015021-pol2qm74	6696	46	mortality	mortality	NN
cord-015021-pol2qm74	6696	47	.	.	.
cord-015021-pol2qm74	6697	1	Among	among	IN
cord-015021-pol2qm74	6697	2	the	the	DT
cord-015021-pol2qm74	6697	3	many	many	JJ
cord-015021-pol2qm74	6697	4	treatments	treatment	NNS
cord-015021-pol2qm74	6697	5	that	that	WDT
cord-015021-pol2qm74	6697	6	have	have	VBP
cord-015021-pol2qm74	6697	7	been	be	VBN
cord-015021-pol2qm74	6697	8	prol	prol	NNP
cord-015021-pol2qm74	6697	9	~	~	NFP
cord-015021-pol2qm74	6697	10	osed	ose	VBN
cord-015021-pol2qm74	6697	11	to	to	TO
cord-015021-pol2qm74	6697	12	treat	treat	VB
cord-015021-pol2qm74	6697	13	this	this	DT
cord-015021-pol2qm74	6697	14	condition	condition	NN
cord-015021-pol2qm74	6697	15	,	,	,
cord-015021-pol2qm74	6697	16	none	none	NN
cord-015021-pol2qm74	6697	17	has	have	VBZ
cord-015021-pol2qm74	6697	18	been	be	VBN
cord-015021-pol2qm74	6697	19	shown	show	VBN
cord-015021-pol2qm74	6697	20	to	to	TO
cord-015021-pol2qm74	6697	21	be	be	VB
cord-015021-pol2qm74	6697	22	satisfactorily	satisfactorily	RB
cord-015021-pol2qm74	6697	23	effective	effective	JJ
cord-015021-pol2qm74	6697	24	.	.	.
cord-015021-pol2qm74	6698	1	Recently	recently	RB
cord-015021-pol2qm74	6698	2	,	,	,
cord-015021-pol2qm74	6698	3	a	a	DT
cord-015021-pol2qm74	6698	4	new	new	JJ
cord-015021-pol2qm74	6698	5	drug	drug	NN
cord-015021-pol2qm74	6698	6	,	,	,
cord-015021-pol2qm74	6698	7	namely	namely	RB
cord-015021-pol2qm74	6698	8	the	the	DT
cord-015021-pol2qm74	6698	9	21-aminosteroid	21-aminosteroid	CD
cord-015021-pol2qm74	6698	10	Tirilazadmesylats	Tirilazadmesylats	NNPS
cord-015021-pol2qm74	6698	11	,	,	,
cord-015021-pol2qm74	6698	12	has	have	VBZ
cord-015021-pol2qm74	6698	13	been	be	VBN
cord-015021-pol2qm74	6698	14	studied	study	VBN
cord-015021-pol2qm74	6698	15	in	in	IN
cord-015021-pol2qm74	6698	16	a	a	DT
cord-015021-pol2qm74	6698	17	large	large	JJ
cord-015021-pol2qm74	6698	18	,	,	,
cord-015021-pol2qm74	6698	19	prospective	prospective	JJ
cord-015021-pol2qm74	6698	20	,	,	,
cord-015021-pol2qm74	6698	21	multicentor	multicentor	NN
cord-015021-pol2qm74	6698	22	trial	trial	NN
cord-015021-pol2qm74	6698	23	for	for	IN
cord-015021-pol2qm74	6698	24	its	-PRON-	PRP$
cord-015021-pol2qm74	6698	25	effectiveness	effectiveness	NN
cord-015021-pol2qm74	6698	26	to	to	TO
cord-015021-pol2qm74	6698	27	improve	improve	VB
cord-015021-pol2qm74	6698	28	the	the	DT
cord-015021-pol2qm74	6698	29	outcome	outcome	NN
cord-015021-pol2qm74	6698	30	of	of	IN
cord-015021-pol2qm74	6698	31	patients	patient	NNS
cord-015021-pol2qm74	6698	32	with	with	IN
cord-015021-pol2qm74	6698	33	aneurysma	aneurysma	NNP
cord-015021-pol2qm74	6698	34	!	!	.
cord-015021-pol2qm74	6699	1	SAId	SAId	NNP
cord-015021-pol2qm74	6699	2	.	.	.
cord-015021-pol2qm74	6700	1	The	the	DT
cord-015021-pol2qm74	6700	2	study	study	NN
cord-015021-pol2qm74	6700	3	was	be	VBD
cord-015021-pol2qm74	6700	4	conducted	conduct	VBN
cord-015021-pol2qm74	6700	5	in	in	IN
cord-015021-pol2qm74	6700	6	Europe	Europe	NNP
cord-015021-pol2qm74	6700	7	and	and	CC
cord-015021-pol2qm74	6700	8	Australia	Australia	NNP
cord-015021-pol2qm74	6700	9	in	in	IN
cord-015021-pol2qm74	6700	10	41	41	CD
cord-015021-pol2qm74	6700	11	neurosurgical	neurosurgical	JJ
cord-015021-pol2qm74	6700	12	centers	center	NNS
cord-015021-pol2qm74	6700	13	and	and	CC
cord-015021-pol2qm74	6700	14	included	include	VBD
cord-015021-pol2qm74	6700	15	1023	1023	CD
cord-015021-pol2qm74	6700	16	patients	patient	NNS
cord-015021-pol2qm74	6700	17	.	.	.
cord-015021-pol2qm74	6701	1	All	all	DT
cord-015021-pol2qm74	6701	2	patients	patient	NNS
cord-015021-pol2qm74	6701	3	received	receive	VBD
cord-015021-pol2qm74	6701	4	presently	presently	RB
cord-015021-pol2qm74	6701	5	accepted	accept	VBN
cord-015021-pol2qm74	6701	6	standard	standard	JJ
cord-015021-pol2qm74	6701	7	treatment	treatment	NN
cord-015021-pol2qm74	6701	8	,	,	,
cord-015021-pol2qm74	6701	9	including	include	VBG
cord-015021-pol2qm74	6701	10	nimodipine	nimodipine	NN
cord-015021-pol2qm74	6701	11	.	.	.
cord-015021-pol2qm74	6702	1	Patients	patient	NNS
cord-015021-pol2qm74	6702	2	were	be	VBD
cord-015021-pol2qm74	6702	3	randomized	randomize	VBN
cord-015021-pol2qm74	6702	4	to	to	IN
cord-015021-pol2qm74	6702	5	four	four	CD
cord-015021-pol2qm74	6702	6	different	different	JJ
cord-015021-pol2qm74	6702	7	groups	group	NNS
cord-015021-pol2qm74	6702	8	:	:	:
cord-015021-pol2qm74	6702	9	placebo	placebo	NN
cord-015021-pol2qm74	6702	10	and	and	CC
cord-015021-pol2qm74	6702	11	8	8	CD
cord-015021-pol2qm74	6702	12	groups	group	NNS
cord-015021-pol2qm74	6702	13	of	of	IN
cord-015021-pol2qm74	6702	14	tirilazad	tirilazad	NNP
cord-015021-pol2qm74	6702	15	in	in	IN
cord-015021-pol2qm74	6702	16	escalating	escalate	VBG
cord-015021-pol2qm74	6702	17	dosage	dosage	NN
cord-015021-pol2qm74	6702	18	(	(	-LRB-
cord-015021-pol2qm74	6702	19	0.6	0.6	CD
cord-015021-pol2qm74	6702	20	-6	-6	CD
cord-015021-pol2qm74	6702	21	mg	mg	NNP
cord-015021-pol2qm74	6702	22	/	/	SYM
cord-015021-pol2qm74	6702	23	kg	kg	NNP
cord-015021-pol2qm74	6702	24	/	/	SYM
cord-015021-pol2qm74	6702	25	day	day	NN
cord-015021-pol2qm74	6702	26	)	)	-RRB-
cord-015021-pol2qm74	6702	27	.	.	.
cord-015021-pol2qm74	6703	1	The	the	DT
cord-015021-pol2qm74	6703	2	clinical	clinical	JJ
cord-015021-pol2qm74	6703	3	outcome	outcome	NN
cord-015021-pol2qm74	6703	4	was	be	VBD
cord-015021-pol2qm74	6703	5	compared	compare	VBN
cord-015021-pol2qm74	6703	6	for	for	IN
cord-015021-pol2qm74	6703	7	these	these	DT
cord-015021-pol2qm74	6703	8	4	4	CD
cord-015021-pol2qm74	6703	9	groups	group	NNS
cord-015021-pol2qm74	6703	10	and	and	CC
cord-015021-pol2qm74	6703	11	cerebral	cerebral	JJ
cord-015021-pol2qm74	6703	12	a	a	DT
cord-015021-pol2qm74	6703	13	~	~	NFP
cord-015021-pol2qm74	6703	14	giography	giography	NNP
cord-015021-pol2qm74	6703	15	was	be	VBD
cord-015021-pol2qm74	6703	16	performed	perform	VBN
cord-015021-pol2qm74	6703	17	in	in	IN
cord-015021-pol2qm74	6703	18	75	75	CD
cord-015021-pol2qm74	6703	19	%	%	NN
cord-015021-pol2qm74	6703	20	of	of	IN
cord-015021-pol2qm74	6703	21	patients	patient	NNS
cord-015021-pol2qm74	6703	22	on	on	IN
cord-015021-pol2qm74	6703	23	day	day	NN
cord-015021-pol2qm74	6703	24	7	7	CD
cord-015021-pol2qm74	6703	25	-11	-11	NN
cord-015021-pol2qm74	6703	26	follovang	follovang	NNP
cord-015021-pol2qm74	6703	27	SAH	SAH	NNP
cord-015021-pol2qm74	6703	28	,	,	,
cord-015021-pol2qm74	6703	29	to	to	TO
cord-015021-pol2qm74	6703	30	study	study	VB
cord-015021-pol2qm74	6703	31	the	the	DT
cord-015021-pol2qm74	6703	32	effect	effect	NN
cord-015021-pol2qm74	6703	33	0f'the	0f'the	CD
cord-015021-pol2qm74	6703	34	dflf~	dflf~	NNP
cord-015021-pol2qm74	6703	35	off	off	RP
cord-015021-pol2qm74	6703	36	Cerebral	cerebral	JJ
cord-015021-pol2qm74	6703	37	vasospasm	vasospasm	NN
cord-015021-pol2qm74	6703	38	.	.	.
cord-015021-pol2qm74	6704	1	The	the	DT
cord-015021-pol2qm74	6704	2	study	study	NN
cord-015021-pol2qm74	6704	3	reached	reach	VBD
cord-015021-pol2qm74	6704	4	its	-PRON-	PRP$
cord-015021-pol2qm74	6704	5	planned	planned	JJ
cord-015021-pol2qm74	6704	6	endpoint	endpoint	NN
cord-015021-pol2qm74	6704	7	6	6	CD
cord-015021-pol2qm74	6704	8	months	month	NNS
cord-015021-pol2qm74	6704	9	ago	ago	RB
cord-015021-pol2qm74	6704	10	.	.	.
cord-015021-pol2qm74	6705	1	Preliminary	preliminary	JJ
cord-015021-pol2qm74	6705	2	results	result	VBZ
cord-015021-pol2qm74	6705	3	~how	~how	NNP
cord-015021-pol2qm74	6705	4	a	a	DT
cord-015021-pol2qm74	6705	5	significant	significant	JJ
cord-015021-pol2qm74	6705	6	improvement	improvement	NN
cord-015021-pol2qm74	6705	7	with	with	IN
cord-015021-pol2qm74	6705	8	regardto	regardto	NN
cord-015021-pol2qm74	6705	9	mortality	mortality	NN
cord-015021-pol2qm74	6705	10	in	in	IN
cord-015021-pol2qm74	6705	11	those	those	DT
cord-015021-pol2qm74	6705	12	patients	patient	NNS
cord-015021-pol2qm74	6705	13	receiving	receive	VBG
cord-015021-pol2qm74	6705	14	the	the	DT
cord-015021-pol2qm74	6705	15	highest	high	JJS
cord-015021-pol2qm74	6705	16	tirilazad	tirilazad	NNP
cord-015021-pol2qm74	6705	17	dose	dose	NN
cord-015021-pol2qm74	6705	18	as	as	IN
cord-015021-pol2qm74	6705	19	compared	compare	VBN
cord-015021-pol2qm74	6705	20	to	to	IN
cord-015021-pol2qm74	6705	21	placebo	placebo	NN
cord-015021-pol2qm74	6705	22	and	and	CC
cord-015021-pol2qm74	6705	23	the	the	DT
cord-015021-pol2qm74	6705	24	two	two	CD
cord-015021-pol2qm74	6705	25	lower	low	JJR
cord-015021-pol2qm74	6705	26	dose	dose	NN
cord-015021-pol2qm74	6705	27	groups	group	NNS
cord-015021-pol2qm74	6705	28	.	.	.
cord-015021-pol2qm74	6706	1	Additional	additional	JJ
cord-015021-pol2qm74	6706	2	beneficial	beneficial	JJ
cord-015021-pol2qm74	6706	3	effects	effect	NNS
cord-015021-pol2qm74	6706	4	were	be	VBD
cord-015021-pol2qm74	6706	5	seen	see	VBN
cord-015021-pol2qm74	6706	6	in	in	IN
cord-015021-pol2qm74	6706	7	the	the	DT
cord-015021-pol2qm74	6706	8	6	6	CD
cord-015021-pol2qm74	6706	9	rag	rag	NN
cord-015021-pol2qm74	6706	10	/	/	SYM
cord-015021-pol2qm74	6706	11	day	day	NN
cord-015021-pol2qm74	6706	12	groups	group	NNS
cord-015021-pol2qm74	6706	13	with	with	IN
cord-015021-pol2qm74	6706	14	regard	regard	NN
cord-015021-pol2qm74	6706	15	to	to	IN
cord-015021-pol2qm74	6706	16	the	the	DT
cord-015021-pol2qm74	6706	17	occurence	occurence	NN
cord-015021-pol2qm74	6706	18	of	of	IN
cord-015021-pol2qm74	6706	19	symptomatic	symptomatic	JJ
cord-015021-pol2qm74	6706	20	vasospasm	vasospasm	NN
cord-015021-pol2qm74	6706	21	and	and	CC
cord-015021-pol2qm74	6706	22	good	good	JJ
cord-015021-pol2qm74	6706	23	clinical	clinical	JJ
cord-015021-pol2qm74	6706	24	outcome	outcome	NN
cord-015021-pol2qm74	6706	25	.	.	.
cord-015021-pol2qm74	6707	1	Although	although	IN
cord-015021-pol2qm74	6707	2	the	the	DT
cord-015021-pol2qm74	6707	3	final	final	JJ
cord-015021-pol2qm74	6707	4	analysis	analysis	NN
cord-015021-pol2qm74	6707	5	of	of	IN
cord-015021-pol2qm74	6707	6	all	all	DT
cord-015021-pol2qm74	6707	7	data	datum	NNS
cord-015021-pol2qm74	6707	8	is	be	VBZ
cord-015021-pol2qm74	6707	9	still	still	RB
cord-015021-pol2qm74	6707	10	pending	pende	VBG
cord-015021-pol2qm74	6707	11	,	,	,
cord-015021-pol2qm74	6707	12	these	these	DT
cord-015021-pol2qm74	6707	13	results	result	NNS
cord-015021-pol2qm74	6707	14	suggest	suggest	VBP
cord-015021-pol2qm74	6707	15	that	that	IN
cord-015021-pol2qm74	6707	16	tirilazad	tirilazad	NNP
cord-015021-pol2qm74	6707	17	-	-	HYPH
cord-015021-pol2qm74	6707	18	mesylate	mesylate	NNP
cord-015021-pol2qm74	6707	19	could	could	MD
cord-015021-pol2qm74	6707	20	represent	represent	VB
cord-015021-pol2qm74	6707	21	a	a	DT
cord-015021-pol2qm74	6707	22	major	major	JJ
cord-015021-pol2qm74	6707	23	improvement	improvement	NN
cord-015021-pol2qm74	6707	24	for	for	IN
cord-015021-pol2qm74	6707	25	the	the	DT
cord-015021-pol2qm74	6707	26	treatment	treatment	NN
cord-015021-pol2qm74	6707	27	of	of	IN
cord-015021-pol2qm74	6707	28	patients	patient	NNS
cord-015021-pol2qm74	6707	29	with	with	IN
cord-015021-pol2qm74	6707	30	SAIl	sail	NN
cord-015021-pol2qm74	6707	31	.	.	.
cord-015021-pol2qm74	6708	1	Experimentally	experimentally	RB
cord-015021-pol2qm74	6708	2	lipidperoxidation	lipidperoxidation	NN
cord-015021-pol2qm74	6708	3	products	product	NNS
cord-015021-pol2qm74	6708	4	(	(	-LRB-
cord-015021-pol2qm74	6708	5	LPO	LPO	NNP
cord-015021-pol2qm74	6708	6	)	)	-RRB-
cord-015021-pol2qm74	6708	7	are	be	VBP
cord-015021-pol2qm74	6708	8	increased	increase	VBN
cord-015021-pol2qm74	6708	9	in	in	IN
cord-015021-pol2qm74	6708	10	acute	acute	JJ
cord-015021-pol2qm74	6708	11	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	6708	12	(	(	-LRB-
cord-015021-pol2qm74	6708	13	AP	AP	NNP
cord-015021-pol2qm74	6708	14	)	)	-RRB-
cord-015021-pol2qm74	6708	15	due	due	IN
cord-015021-pol2qm74	6708	16	to	to	IN
cord-015021-pol2qm74	6708	17	oxygen	oxygen	NN
cord-015021-pol2qm74	6708	18	radicals	radical	NNS
cord-015021-pol2qm74	6708	19	(	(	-LRB-
cord-015021-pol2qm74	6708	20	OR	or	CC
cord-015021-pol2qm74	6708	21	)	)	-RRB-
cord-015021-pol2qm74	6708	22	.	.	.
cord-015021-pol2qm74	6709	1	The	the	DT
cord-015021-pol2qm74	6709	2	purpose	purpose	NN
cord-015021-pol2qm74	6709	3	of	of	IN
cord-015021-pol2qm74	6709	4	this	this	DT
cord-015021-pol2qm74	6709	5	clinical	clinical	JJ
cord-015021-pol2qm74	6709	6	study	study	NN
cord-015021-pol2qm74	6709	7	was	be	VBD
cord-015021-pol2qm74	6709	8	to	to	TO
cord-015021-pol2qm74	6709	9	determine	determine	VB
cord-015021-pol2qm74	6709	10	the	the	DT
cord-015021-pol2qm74	6709	11	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6709	12	status	status	NN
cord-015021-pol2qm74	6709	13	and	and	CC
cord-015021-pol2qm74	6709	14	LPO	LPO	NNP
cord-015021-pol2qm74	6709	15	in	in	IN
cord-015021-pol2qm74	6709	16	patients	patient	NNS
cord-015021-pol2qm74	6709	17	suffering	suffer	VBG
cord-015021-pol2qm74	6709	18	from	from	IN
cord-015021-pol2qm74	6709	19	AP	AP	NNP
cord-015021-pol2qm74	6709	20	and	and	CC
cord-015021-pol2qm74	6709	21	tO	to	TO
cord-015021-pol2qm74	6709	22	evaluate	evaluate	VB
cord-015021-pol2qm74	6709	23	the	the	DT
cord-015021-pol2qm74	6709	24	effect	effect	NN
cord-015021-pol2qm74	6709	25	of	of	IN
cord-015021-pol2qm74	6709	26	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6709	27	treatment	treatment	NN
cord-015021-pol2qm74	6709	28	with	with	IN
cord-015021-pol2qm74	6709	29	sodium	sodium	NN
cord-015021-pol2qm74	6709	30	selenite	selenite	NN
cord-015021-pol2qm74	6709	31	(	(	-LRB-
cord-015021-pol2qm74	6709	32	SE	SE	NNP
cord-015021-pol2qm74	6709	33	)	)	-RRB-
cord-015021-pol2qm74	6709	34	thus	thus	RB
cord-015021-pol2qm74	6709	35	improving	improve	VBG
cord-015021-pol2qm74	6709	36	the	the	DT
cord-015021-pol2qm74	6709	37	function	function	NN
cord-015021-pol2qm74	6709	38	of	of	IN
cord-015021-pol2qm74	6709	39	the	the	DT
cord-015021-pol2qm74	6709	40	SE	SE	NNP
cord-015021-pol2qm74	6709	41	dependant	dependant	JJ
cord-015021-pol2qm74	6709	42	glutathione	glutathione	NN
cord-015021-pol2qm74	6709	43	peroxidase	peroxidase	NN
cord-015021-pol2qm74	6709	44	which	which	WDT
cord-015021-pol2qm74	6709	45	is	be	VBZ
cord-015021-pol2qm74	6709	46	the	the	DT
cord-015021-pol2qm74	6709	47	major	major	JJ
cord-015021-pol2qm74	6709	48	detoxifying	detoxify	VBG
cord-015021-pol2qm74	6709	49	system	system	NN
cord-015021-pol2qm74	6709	50	for	for	IN
cord-015021-pol2qm74	6709	51	OR	OR	NNP
cord-015021-pol2qm74	6709	52	.	.	.
cord-015021-pol2qm74	6710	1	Materials	material	NNS
cord-015021-pol2qm74	6710	2	and	and	CC
cord-015021-pol2qm74	6710	3	Methods	method	NNS
cord-015021-pol2qm74	6710	4	:	:	:
cord-015021-pol2qm74	6711	1	In	in	IN
cord-015021-pol2qm74	6711	2	Z0	Z0	NNP
cord-015021-pol2qm74	6711	3	patients	patient	NNS
cord-015021-pol2qm74	6711	4	sufferin	sufferin	NNP
cord-015021-pol2qm74	6711	5	s	s	NNP
cord-015021-pol2qm74	6711	6	from	from	IN
cord-015021-pol2qm74	6711	7	severe	severe	JJ
cord-015021-pol2qm74	6711	8	AP	AP	NNP
cord-015021-pol2qm74	6711	9	(	(	-LRB-
cord-015021-pol2qm74	6711	10	C	C	NNP
cord-015021-pol2qm74	6711	11	-	-	HYPH
cord-015021-pol2qm74	6711	12	reactlve	reactlve	NN
cord-015021-pol2qm74	6711	13	protein	protein	NN
cord-015021-pol2qm74	6712	1	>	>	XX
cord-015021-pol2qm74	6713	1	120	120	CD
cord-015021-pol2qm74	6713	2	mE	mE	NNP
cord-015021-pol2qm74	6713	3	/	/	SYM
cord-015021-pol2qm74	6713	4	l	l	NN
cord-015021-pol2qm74	6713	5	)	)	-RRB-
cord-015021-pol2qm74	6714	1	we	-PRON-	PRP
cord-015021-pol2qm74	6714	2	determined	determine	VBD
cord-015021-pol2qm74	6714	3	on	on	IN
cord-015021-pol2qm74	6714	4	day	day	NN
cord-015021-pol2qm74	6714	5	1	1	CD
cord-015021-pol2qm74	6714	6	and	and	CC
cord-015021-pol2qm74	6714	7	day	day	NN
cord-015021-pol2qm74	6714	8	8	8	CD
cord-015021-pol2qm74	6714	9	after	after	IN
cord-015021-pol2qm74	6714	10	admission	admission	NN
cord-015021-pol2qm74	6715	1	the	the	DT
cord-015021-pol2qm74	6715	2	LPO	LPO	NNP
cord-015021-pol2qm74	6715	3	ma!ondialdehyd	ma!ondialdehyd	IN
cord-015021-pol2qm74	6715	4	(	(	-LRB-
cord-015021-pol2qm74	6715	5	MDA	MDA	NNP
cord-015021-pol2qm74	6715	6	)	)	-RRB-
cord-015021-pol2qm74	6715	7	,	,	,
cord-015021-pol2qm74	6715	8	conjugated	conjugate	VBN
cord-015021-pol2qm74	6715	9	dishes	dish	NNS
cord-015021-pol2qm74	6715	10	(	(	-LRB-
cord-015021-pol2qm74	6715	11	CD	CD	NNP
cord-015021-pol2qm74	6715	12	)	)	-RRB-
cord-015021-pol2qm74	6715	13	,	,	,
cord-015021-pol2qm74	6715	14	reduced	reduce	VBN
cord-015021-pol2qm74	6715	15	(	(	-LRB-
cord-015021-pol2qm74	6715	16	GSR	GSR	NNP
cord-015021-pol2qm74	6715	17	)	)	-RRB-
cord-015021-pol2qm74	6715	18	and	and	CC
cord-015021-pol2qm74	6715	19	oxidized	oxidize	VBN
cord-015021-pol2qm74	6715	20	(	(	-LRB-
cord-015021-pol2qm74	6716	1	GSSG	GSSG	NNP
cord-015021-pol2qm74	6716	2	)	)	-RRB-
cord-015021-pol2qm74	6716	3	glutathione	glutathione	NN
cord-015021-pol2qm74	6716	4	,	,	,
cord-015021-pol2qm74	6716	5	the	the	DT
cord-015021-pol2qm74	6716	6	vitamins	vitamin	NNS
cord-015021-pol2qm74	6716	7	A	A	NNP
cord-015021-pol2qm74	6716	8	,	,	,
cord-015021-pol2qm74	6716	9	C	C	NNP
cord-015021-pol2qm74	6716	10	,	,	,
cord-015021-pol2qm74	6716	11	E	E	NNP
cord-015021-pol2qm74	6716	12	and	and	CC
cord-015021-pol2qm74	6716	13	SE	SE	NNP
cord-015021-pol2qm74	6716	14	.	.	.
cord-015021-pol2qm74	6717	1	Moreover	moreover	RB
cord-015021-pol2qm74	6717	2	the	the	DT
cord-015021-pol2qm74	6717	3	patients	patient	NNS
cord-015021-pol2qm74	6717	4	were	be	VBD
cord-015021-pol2qm74	6717	5	evaluated	evaluate	VBN
cord-015021-pol2qm74	6717	6	clinically	clinically	RB
cord-015021-pol2qm74	6717	7	using	use	VBG
cord-015021-pol2qm74	6717	8	the	the	DT
cord-015021-pol2qm74	6717	9	RANSON	RANSON	NNP
cord-015021-pol2qm74	6717	10	and	and	CC
cord-015021-pol2qm74	6717	11	the	the	DT
cord-015021-pol2qm74	6717	12	APACHE	APACHE	NNP
cord-015021-pol2qm74	6717	13	II	II	NNP
cord-015021-pol2qm74	6717	14	score	score	NN
cord-015021-pol2qm74	6717	15	.	.	.
cord-015021-pol2qm74	6718	1	I0	i0	NN
cord-015021-pol2qm74	6718	2	patients	patient	NNS
cord-015021-pol2qm74	6718	3	were	be	VBD
cord-015021-pol2qm74	6718	4	randomly	randomly	RB
cord-015021-pol2qm74	6718	5	treated	treat	VBN
cord-015021-pol2qm74	6718	6	with	with	IN
cord-015021-pol2qm74	6718	7	600	600	CD
cord-015021-pol2qm74	6718	8	ug	ug	NNP
cord-015021-pol2qm74	6718	9	/	/	SYM
cord-015021-pol2qm74	6718	10	day	day	NN
cord-015021-pol2qm74	6718	11	of	of	IN
cord-015021-pol2qm74	6718	12	SE	SE	NNP
cord-015021-pol2qm74	6718	13	for	for	IN
cord-015021-pol2qm74	6718	14	8	8	CD
cord-015021-pol2qm74	6718	15	days	day	NNS
cord-015021-pol2qm74	6718	16	.	.	.
cord-015021-pol2qm74	6719	1	Results	result	NNS
cord-015021-pol2qm74	6719	2	:	:	:
cord-015021-pol2qm74	6720	1	All	all	DT
cord-015021-pol2qm74	6720	2	patients	patient	NNS
cord-015021-pol2qm74	6720	3	suffered	suffer	VBD
cord-015021-pol2qm74	6720	4	from	from	IN
cord-015021-pol2qm74	6720	5	a	a	DT
cord-015021-pol2qm74	6720	6	severe	severe	JJ
cord-015021-pol2qm74	6720	7	depletion	depletion	NN
cord-015021-pol2qm74	6720	8	of	of	IN
cord-015021-pol2qm74	6720	9	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	6720	10	,	,	,
cord-015021-pol2qm74	6720	11	especially	especially	RB
cord-015021-pol2qm74	6720	12	a	a	DT
cord-015021-pol2qm74	6720	13	low	low	JJ
cord-015021-pol2qm74	6720	14	concentration	concentration	NN
cord-015021-pol2qm74	6720	15	of	of	IN
cord-015021-pol2qm74	6720	16	SE	SE	NNP
cord-015021-pol2qm74	6720	17	(	(	-LRB-
cord-015021-pol2qm74	6720	18	only	only	RB
cord-015021-pol2qm74	6720	19	1/3	1/3	CD
cord-015021-pol2qm74	6720	20	of	of	IN
cord-015021-pol2qm74	6720	21	normal	normal	JJ
cord-015021-pol2qm74	6720	22	)	)	-RRB-
cord-015021-pol2qm74	6720	23	.	.	.
cord-015021-pol2qm74	6721	1	Thereby	thereby	RB
cord-015021-pol2qm74	6721	2	the	the	DT
cord-015021-pol2qm74	6721	3	increase	increase	NN
cord-015021-pol2qm74	6721	4	in	in	IN
cord-015021-pol2qm74	6721	5	LPO	LPO	NNP
cord-015021-pol2qm74	6721	6	correlated	correlate	VBD
cord-015021-pol2qm74	6721	7	with	with	IN
cord-015021-pol2qm74	6721	8	the	the	DT
cord-015021-pol2qm74	6721	9	clinical	clinical	JJ
cord-015021-pol2qm74	6721	10	course	course	NN
cord-015021-pol2qm74	6721	11	.	.	.
cord-015021-pol2qm74	6722	1	During	during	IN
cord-015021-pol2qm74	6722	2	SE	SE	NNP
cord-015021-pol2qm74	6722	3	treatment	treatment	NN
cord-015021-pol2qm74	6722	4	LPO	LPO	NNP
cord-015021-pol2qm74	6722	5	decreased	decrease	VBD
cord-015021-pol2qm74	6722	6	and	and	CC
cord-015021-pol2qm74	6722	7	the	the	DT
cord-015021-pol2qm74	6722	8	levels	level	NNS
cord-015021-pol2qm74	6722	9	of	of	IN
cord-015021-pol2qm74	6722	10	antioxidant	antioxidant	JJ
cord-015021-pol2qm74	6722	11	vitamins	vitamin	NNS
cord-015021-pol2qm74	6722	12	improved	improve	VBD
cord-015021-pol2qm74	6722	13	.	.	.
cord-015021-pol2qm74	6723	1	SE	SE	NNP
cord-015021-pol2qm74	6723	2	had	have	VBD
cord-015021-pol2qm74	6723	3	no	no	DT
cord-015021-pol2qm74	6723	4	influence	influence	NN
cord-015021-pol2qm74	6723	5	on	on	IN
cord-015021-pol2qm74	6723	6	leth	leth	NN
cord-015021-pol2qm74	6723	7	-	-	HYPH
cord-015021-pol2qm74	6723	8	slity	slity	NN
cord-015021-pol2qm74	6723	9	the	the	DT
cord-015021-pol2qm74	6723	10	lenl	lenl	NNP
cord-015021-pol2qm74	6723	11	or	or	CC
cord-015021-pol2qm74	6723	12	the	the	DT
cord-015021-pol2qm74	6723	13	chan	chan	NNP
cord-015021-pol2qm74	6723	14	in	in	IN
cord-015021-pol2qm74	6723	15	RS	RS	NNP
cord-015021-pol2qm74	6723	16	or	or	CC
cord-015021-pol2qm74	6723	17	AP	AP	NNP
cord-015021-pol2qm74	6723	18	II	II	NNP
cord-015021-pol2qm74	6723	19	.	.	.
cord-015021-pol2qm74	6724	1	Background	background	NN
cord-015021-pol2qm74	6724	2	:	:	:
cord-015021-pol2qm74	6725	1	Since	since	IN
cord-015021-pol2qm74	6725	2	reperfusion	reperfusion	NN
cord-015021-pol2qm74	6725	3	injury	injury	NN
cord-015021-pol2qm74	6725	4	occurs	occur	VBZ
cord-015021-pol2qm74	6725	5	when	when	WRB
cord-015021-pol2qm74	6725	6	oxygen	oxygen	NN
cord-015021-pol2qm74	6725	7	is	be	VBZ
cord-015021-pol2qm74	6725	8	reintroduced	reintroduce	VBN
cord-015021-pol2qm74	6725	9	into	into	IN
cord-015021-pol2qm74	6725	10	ischemic	ischemic	JJ
cord-015021-pol2qm74	6725	11	tissue	tissue	NN
cord-015021-pol2qm74	6725	12	,	,	,
cord-015021-pol2qm74	6725	13	the	the	DT
cord-015021-pol2qm74	6725	14	ideal	ideal	JJ
cord-015021-pol2qm74	6725	15	timing	timing	NN
cord-015021-pol2qm74	6725	16	for	for	IN
cord-015021-pol2qm74	6725	17	administration	administration	NN
cord-015021-pol2qm74	6725	18	of	of	IN
cord-015021-pol2qm74	6725	19	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	6725	20	compounds	compound	NNS
cord-015021-pol2qm74	6725	21	aimed	aim	VBN
cord-015021-pol2qm74	6725	22	at	at	IN
cord-015021-pol2qm74	6725	23	ameliorating	ameliorate	VBG
cord-015021-pol2qm74	6725	24	oxygen	oxygen	NN
cord-015021-pol2qm74	6725	25	radical	radical	JJ
cord-015021-pol2qm74	6725	26	mediated	mediate	VBN
cord-015021-pol2qm74	6725	27	injury	injury	NN
cord-015021-pol2qm74	6725	28	is	be	VBZ
cord-015021-pol2qm74	6725	29	at	at	IN
cord-015021-pol2qm74	6725	30	the	the	DT
cord-015021-pol2qm74	6725	31	time	time	NN
cord-015021-pol2qm74	6725	32	of	of	IN
cord-015021-pol2qm74	6725	33	initial	initial	JJ
cord-015021-pol2qm74	6725	34	fluid	fluid	JJ
cord-015021-pol2qm74	6725	35	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6725	36	.	.	.
cord-015021-pol2qm74	6726	1	Currently	currently	RB
cord-015021-pol2qm74	6726	2	used	use	VBN
cord-015021-pol2qm74	6726	3	colloid	colloid	NN
cord-015021-pol2qm74	6726	4	or	or	CC
cord-015021-pol2qm74	6726	5	crystalloid	crystalloid	NN
cord-015021-pol2qm74	6726	6	preparations	preparation	NNS
cord-015021-pol2qm74	6726	7	do	do	VBP
cord-015021-pol2qm74	6726	8	not	not	RB
cord-015021-pol2qm74	6726	9	provide	provide	VB
cord-015021-pol2qm74	6726	10	optimal	optimal	JJ
cord-015021-pol2qm74	6726	11	,	,	,
cord-015021-pol2qm74	6726	12	or	or	CC
cord-015021-pol2qm74	6726	13	even	even	RB
cord-015021-pol2qm74	6726	14	significant	significant	JJ
cord-015021-pol2qm74	6726	15	,	,	,
cord-015021-pol2qm74	6726	16	anti	anti	JJ
cord-015021-pol2qm74	6726	17	-	-	JJ
cord-015021-pol2qm74	6726	18	oxidant	oxidant	JJ
cord-015021-pol2qm74	6726	19	protection	protection	NN
cord-015021-pol2qm74	6726	20	.	.	.
cord-015021-pol2qm74	6727	1	Systemic	systemic	JJ
cord-015021-pol2qm74	6727	2	iron	iron	NN
cord-015021-pol2qm74	6727	3	chelation	chelation	NN
cord-015021-pol2qm74	6727	4	affords	afford	VBZ
cord-015021-pol2qm74	6727	5	protection	protection	NN
cord-015021-pol2qm74	6727	6	against	against	IN
cord-015021-pol2qm74	6727	7	the	the	DT
cord-015021-pol2qm74	6727	8	iron	iron	NN
cord-015021-pol2qm74	6727	9	catalyzed	catalyze	VBN
cord-015021-pol2qm74	6727	10	components	component	NNS
cord-015021-pol2qm74	6727	11	of	of	IN
cord-015021-pol2qm74	6727	12	oxygen	oxygen	NN
cord-015021-pol2qm74	6727	13	and	and	CC
cord-015021-pol2qm74	6727	14	lipid	lipid	NN
cord-015021-pol2qm74	6727	15	radical	radical	JJ
cord-015021-pol2qm74	6727	16	mediated	mediate	VBN
cord-015021-pol2qm74	6727	17	tissue	tissue	NN
cord-015021-pol2qm74	6727	18	injury	injury	NN
cord-015021-pol2qm74	6727	19	.	.	.
cord-015021-pol2qm74	6728	1	The	the	DT
cord-015021-pol2qm74	6728	2	conjugate	conjugate	NN
cord-015021-pol2qm74	6728	3	resulting	result	VBG
cord-015021-pol2qm74	6728	4	from	from	IN
cord-015021-pol2qm74	6728	5	chemical	chemical	JJ
cord-015021-pol2qm74	6728	6	attachment	attachment	NN
cord-015021-pol2qm74	6728	7	of	of	IN
cord-015021-pol2qm74	6728	8	the	the	DT
cord-015021-pol2qm74	6728	9	clinically	clinically	RB
cord-015021-pol2qm74	6728	10	approved	approve	VBN
cord-015021-pol2qm74	6728	11	iron	iron	NN
cord-015021-pol2qm74	6728	12	chelator	chelator	NN
cord-015021-pol2qm74	6728	13	,	,	,
cord-015021-pol2qm74	6728	14	deferoxamine	deferoxamine	NNP
cord-015021-pol2qm74	6728	15	(	(	-LRB-
cord-015021-pol2qm74	6728	16	DFO	DFO	NNP
cord-015021-pol2qm74	6728	17	,	,	,
cord-015021-pol2qm74	6728	18	Desferal	Desferal	NNP
cord-015021-pol2qm74	6728	19	®	®	NNP
cord-015021-pol2qm74	6728	20	,	,	,
cord-015021-pol2qm74	6728	21	Ciba	Ciba	NNP
cord-015021-pol2qm74	6728	22	)	)	-RRB-
cord-015021-pol2qm74	6728	23	,	,	,
cord-015021-pol2qm74	6728	24	to	to	IN
cord-015021-pol2qm74	6728	25	hydroxyethyl	hydroxyethyl	NN
cord-015021-pol2qm74	6728	26	starch	starch	NN
cord-015021-pol2qm74	6728	27	(	(	-LRB-
cord-015021-pol2qm74	6728	28	HES	HES	NNP
cord-015021-pol2qm74	6728	29	)	)	-RRB-
cord-015021-pol2qm74	6728	30	represents	represent	VBZ
cord-015021-pol2qm74	6728	31	a	a	DT
cord-015021-pol2qm74	6728	32	novel	novel	JJ
cord-015021-pol2qm74	6728	33	approach	approach	NN
cord-015021-pol2qm74	6728	34	to	to	IN
cord-015021-pol2qm74	6728	35	colloid	colloid	NN
cord-015021-pol2qm74	6728	36	based	base	VBN
cord-015021-pol2qm74	6728	37	fluid	fluid	JJ
cord-015021-pol2qm74	6728	38	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6728	39	.	.	.
cord-015021-pol2qm74	6729	1	HES	HES	NNP
cord-015021-pol2qm74	6729	2	-	-	HYPH
cord-015021-pol2qm74	6729	3	DFO	DFO	NNP
cord-015021-pol2qm74	6729	4	contains	contain	VBZ
cord-015021-pol2qm74	6729	5	85	85	CD
cord-015021-pol2qm74	6729	6	%	%	NN
cord-015021-pol2qm74	6729	7	HES	hes	NN
cord-015021-pol2qm74	6729	8	and	and	CC
cord-015021-pol2qm74	6730	1	15	15	CD
cord-015021-pol2qm74	6730	2	%	%	NN
cord-015021-pol2qm74	6730	3	chemically	chemically	RB
cord-015021-pol2qm74	6730	4	bound	bind	VBN
cord-015021-pol2qm74	6730	5	DFO	DFO	NNP
cord-015021-pol2qm74	6730	6	.	.	.
cord-015021-pol2qm74	6731	1	The	the	DT
cord-015021-pol2qm74	6731	2	polymer	polymer	NN
cord-015021-pol2qm74	6731	3	-	-	HYPH
cord-015021-pol2qm74	6731	4	drug	drug	NN
cord-015021-pol2qm74	6731	5	conjugate	conjugate	NN
cord-015021-pol2qm74	6731	6	has	have	VBZ
cord-015021-pol2qm74	6731	7	a	a	DT
cord-015021-pol2qm74	6731	8	lower	low	JJR
cord-015021-pol2qm74	6731	9	molecular	molecular	JJ
cord-015021-pol2qm74	6731	10	weight	weight	NN
cord-015021-pol2qm74	6731	11	than	than	IN
cord-015021-pol2qm74	6731	12	that	that	DT
cord-015021-pol2qm74	6731	13	of	of	IN
cord-015021-pol2qm74	6731	14	HES	HES	NNP
cord-015021-pol2qm74	6731	15	in	in	IN
cord-015021-pol2qm74	6731	16	order	order	NN
cord-015021-pol2qm74	6731	17	to	to	TO
cord-015021-pol2qm74	6731	18	allow	allow	VB
cord-015021-pol2qm74	6731	19	more	more	RBR
cord-015021-pol2qm74	6731	20	rapid	rapid	JJ
cord-015021-pol2qm74	6731	21	excretion	excretion	NN
cord-015021-pol2qm74	6731	22	.	.	.
cord-015021-pol2qm74	6732	1	Results	result	NNS
cord-015021-pol2qm74	6732	2	:	:	:
cord-015021-pol2qm74	6733	1	Preclinical	preclinical	JJ
cord-015021-pol2qm74	6733	2	and	and	CC
cord-015021-pol2qm74	6733	3	initial	initial	JJ
cord-015021-pol2qm74	6733	4	clinical	clinical	JJ
cord-015021-pol2qm74	6733	5	trials	trial	NNS
cord-015021-pol2qm74	6733	6	indicate	indicate	VBP
cord-015021-pol2qm74	6733	7	that	that	IN
cord-015021-pol2qm74	6733	8	HES	HES	NNP
cord-015021-pol2qm74	6733	9	-	-	HYPH
cord-015021-pol2qm74	6733	10	DFO	DFO	NNP
cord-015021-pol2qm74	6733	11	is	be	VBZ
cord-015021-pol2qm74	6733	12	well	well	RB
cord-015021-pol2qm74	6733	13	tolerated	tolerate	VBN
cord-015021-pol2qm74	6733	14	,	,	,
cord-015021-pol2qm74	6733	15	even	even	RB
cord-015021-pol2qm74	6733	16	at	at	IN
cord-015021-pol2qm74	6733	17	high	high	JJ
cord-015021-pol2qm74	6733	18	doses	dose	NNS
cord-015021-pol2qm74	6733	19	.	.	.
cord-015021-pol2qm74	6734	1	In	in	IN
cord-015021-pol2qm74	6734	2	animal	animal	NN
cord-015021-pol2qm74	6734	3	studies	study	NNS
cord-015021-pol2qm74	6734	4	,	,	,
cord-015021-pol2qm74	6734	5	fluid	fluid	JJ
cord-015021-pol2qm74	6734	6	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6734	7	with	with	IN
cord-015021-pol2qm74	6734	8	HES	HES	NNP
cord-015021-pol2qm74	6734	9	-	-	HYPH
cord-015021-pol2qm74	6734	10	DFO	DFO	NNP
cord-015021-pol2qm74	6734	11	does	do	VBZ
cord-015021-pol2qm74	6734	12	not	not	RB
cord-015021-pol2qm74	6734	13	significantly	significantly	RB
cord-015021-pol2qm74	6734	14	improve	improve	VB
cord-015021-pol2qm74	6734	15	central	central	JJ
cord-015021-pol2qm74	6734	16	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	6734	17	recovery	recovery	NN
cord-015021-pol2qm74	6734	18	beyond	beyond	IN
cord-015021-pol2qm74	6734	19	that	that	DT
cord-015021-pol2qm74	6734	20	observed	observe	VBD
cord-015021-pol2qm74	6734	21	with	with	IN
cord-015021-pol2qm74	6734	22	HES	HES	NNP
cord-015021-pol2qm74	6734	23	,	,	,
cord-015021-pol2qm74	6734	24	but	but	CC
cord-015021-pol2qm74	6734	25	HES	HES	NNP
cord-015021-pol2qm74	6734	26	-	-	HYPH
cord-015021-pol2qm74	6734	27	DFO	DFO	NNP
cord-015021-pol2qm74	6734	28	seems	seem	VBZ
cord-015021-pol2qm74	6734	29	to	to	TO
cord-015021-pol2qm74	6734	30	afford	afford	VB
cord-015021-pol2qm74	6734	31	better	well	JJR
cord-015021-pol2qm74	6734	32	protection	protection	NN
cord-015021-pol2qm74	6734	33	of	of	IN
cord-015021-pol2qm74	6734	34	microcirculation	microcirculation	NN
cord-015021-pol2qm74	6734	35	in	in	IN
cord-015021-pol2qm74	6734	36	organs	organ	NNS
cord-015021-pol2qm74	6734	37	at	at	IN
cord-015021-pol2qm74	6734	38	risk	risk	NN
cord-015021-pol2qm74	6734	39	(	(	-LRB-
cord-015021-pol2qm74	6734	40	lung	lung	NN
cord-015021-pol2qm74	6734	41	,	,	,
cord-015021-pol2qm74	6734	42	liver	liver	NN
cord-015021-pol2qm74	6734	43	and	and	CC
cord-015021-pol2qm74	6734	44	gut	gut	NN
cord-015021-pol2qm74	6734	45	)	)	-RRB-
cord-015021-pol2qm74	6734	46	,	,	,
cord-015021-pol2qm74	6734	47	possibly	possibly	RB
cord-015021-pol2qm74	6734	48	by	by	IN
cord-015021-pol2qm74	6734	49	decreasing	decrease	VBG
cord-015021-pol2qm74	6734	50	neutrophil	neutrophil	NN
cord-015021-pol2qm74	6734	51	sequestration	sequestration	NN
cord-015021-pol2qm74	6734	52	.	.	.
cord-015021-pol2qm74	6735	1	In	in	IN
cord-015021-pol2qm74	6735	2	a	a	DT
cord-015021-pol2qm74	6735	3	burn	burn	NN
cord-015021-pol2qm74	6735	4	model	model	NN
cord-015021-pol2qm74	6735	5	,	,	,
cord-015021-pol2qm74	6735	6	total	total	JJ
cord-015021-pol2qm74	6735	7	fluid	fluid	JJ
cord-015021-pol2qm74	6735	8	requirements	requirement	NNS
cord-015021-pol2qm74	6735	9	are	be	VBP
cord-015021-pol2qm74	6735	10	lower	low	JJR
cord-015021-pol2qm74	6735	11	and	and	CC
cord-015021-pol2qm74	6735	12	oxygen	oxygen	NN
cord-015021-pol2qm74	6735	13	utilization	utilization	NN
cord-015021-pol2qm74	6735	14	higher	high	JJR
cord-015021-pol2qm74	6735	15	in	in	IN
cord-015021-pol2qm74	6735	16	HES	HES	NNP
cord-015021-pol2qm74	6735	17	-	-	HYPH
cord-015021-pol2qm74	6735	18	DFO	DFO	NNP
cord-015021-pol2qm74	6736	1	treated	treat	VBN
cord-015021-pol2qm74	6736	2	animals	animal	NNS
cord-015021-pol2qm74	6736	3	compared	compare	VBN
cord-015021-pol2qm74	6736	4	to	to	IN
cord-015021-pol2qm74	6736	5	HES	HES	NNP
cord-015021-pol2qm74	6736	6	controls	control	NNS
cord-015021-pol2qm74	6736	7	,	,	,
cord-015021-pol2qm74	6736	8	suggesting	suggest	VBG
cord-015021-pol2qm74	6736	9	decreased	decrease	VBD
cord-015021-pol2qm74	6736	10	vascular	vascular	JJ
cord-015021-pol2qm74	6736	11	leak	leak	NN
cord-015021-pol2qm74	6736	12	and	and	CC
cord-015021-pol2qm74	6736	13	improved	improved	JJ
cord-015021-pol2qm74	6736	14	tissue	tissue	NN
cord-015021-pol2qm74	6736	15	perfusion	perfusion	NN
cord-015021-pol2qm74	6736	16	.	.	.
cord-015021-pol2qm74	6737	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	6737	2	:	:	:
cord-015021-pol2qm74	6738	1	HES	HES	NNP
cord-015021-pol2qm74	6738	2	-	-	HYPH
cord-015021-pol2qm74	6738	3	DFO	DFO	NNP
cord-015021-pol2qm74	6738	4	represents	represent	VBZ
cord-015021-pol2qm74	6738	5	a	a	DT
cord-015021-pol2qm74	6738	6	means	means	NN
cord-015021-pol2qm74	6738	7	by	by	IN
cord-015021-pol2qm74	6738	8	which	which	WDT
cord-015021-pol2qm74	6738	9	potent	potent	JJ
cord-015021-pol2qm74	6738	10	antioxidant	antioxidant	NN
cord-015021-pol2qm74	6738	11	protection	protection	NN
cord-015021-pol2qm74	6738	12	can	can	MD
cord-015021-pol2qm74	6738	13	be	be	VB
cord-015021-pol2qm74	6738	14	administered	administer	VBN
cord-015021-pol2qm74	6738	15	at	at	IN
cord-015021-pol2qm74	6738	16	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6738	17	.	.	.
cord-015021-pol2qm74	6739	1	Iron	iron	NN
cord-015021-pol2qm74	6739	2	has	have	VBZ
cord-015021-pol2qm74	6739	3	been	be	VBN
cord-015021-pol2qm74	6739	4	suggested	suggest	VBN
cord-015021-pol2qm74	6739	5	to	to	TO
cord-015021-pol2qm74	6739	6	play	play	VB
cord-015021-pol2qm74	6739	7	a	a	DT
cord-015021-pol2qm74	6739	8	pivotal	pivotal	JJ
cord-015021-pol2qm74	6739	9	role	role	NN
cord-015021-pol2qm74	6739	10	in	in	IN
cord-015021-pol2qm74	6739	11	oxygen	oxygen	NN
cord-015021-pol2qm74	6739	12	flee	flee	NN
cord-015021-pol2qm74	6739	13	radical	radical	JJ
cord-015021-pol2qm74	6739	14	mediated	mediate	VBN
cord-015021-pol2qm74	6739	15	tissue	tissue	NN
cord-015021-pol2qm74	6739	16	injury	injury	NN
cord-015021-pol2qm74	6739	17	.	.	.
cord-015021-pol2qm74	6740	1	In	in	IN
cord-015021-pol2qm74	6740	2	vitro	vitro	FW
cord-015021-pol2qm74	6740	3	experiments	experiment	NNS
cord-015021-pol2qm74	6740	4	indicated	indicate	VBD
cord-015021-pol2qm74	6740	5	its	-PRON-	PRP$
cord-015021-pol2qm74	6740	6	critical	critical	JJ
cord-015021-pol2qm74	6740	7	role	role	NN
cord-015021-pol2qm74	6740	8	as	as	IN
cord-015021-pol2qm74	6740	9	a	a	DT
cord-015021-pol2qm74	6740	10	katalyst	katalyst	NN
cord-015021-pol2qm74	6740	11	in	in	IN
cord-015021-pol2qm74	6740	12	hydroxyl	hydroxyl	NN
cord-015021-pol2qm74	6740	13	free	free	JJ
cord-015021-pol2qm74	6740	14	radical	radical	JJ
cord-015021-pol2qm74	6740	15	generation	generation	NN
cord-015021-pol2qm74	6740	16	0Fenton	0fenton	JJ
cord-015021-pol2qm74	6740	17	-	-	HYPH
cord-015021-pol2qm74	6740	18	reaction	reaction	NN
cord-015021-pol2qm74	6740	19	)	)	-RRB-
cord-015021-pol2qm74	6740	20	.	.	.
cord-015021-pol2qm74	6741	1	Since	since	IN
cord-015021-pol2qm74	6741	2	iron	iron	NN
cord-015021-pol2qm74	6741	3	chelator	chelator	NN
cord-015021-pol2qm74	6741	4	deferoxamine	deferoxamine	NN
cord-015021-pol2qm74	6741	5	administered	administer	VBN
cord-015021-pol2qm74	6741	6	in	in	IN
cord-015021-pol2qm74	6741	7	shock	shock	NN
cord-015021-pol2qm74	6741	8	alone	alone	RB
cord-015021-pol2qm74	6741	9	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	6741	10	severe	severe	JJ
cord-015021-pol2qm74	6741	11	side	side	NN
cord-015021-pol2qm74	6741	12	effects	effect	NNS
cord-015021-pol2qm74	6741	13	,	,	,
cord-015021-pol2qm74	6741	14	a	a	DT
cord-015021-pol2qm74	6741	15	hydroxyethylstarch	hydroxyethylstarch	NN
cord-015021-pol2qm74	6741	16	(	(	-LRB-
cord-015021-pol2qm74	6741	17	HES)daferoxamine	HES)daferoxamine	NNP
cord-015021-pol2qm74	6741	18	(	(	-LRB-
cord-015021-pol2qm74	6741	19	DFO)-conjugute	DFO)-conjugute	NNP
cord-015021-pol2qm74	6741	20	was	be	VBD
cord-015021-pol2qm74	6741	21	used	use	VBN
cord-015021-pol2qm74	6741	22	to	to	TO
cord-015021-pol2qm74	6741	23	modulate	modulate	VB
cord-015021-pol2qm74	6741	24	oxygen	oxygen	NN
cord-015021-pol2qm74	6741	25	free	free	JJ
cord-015021-pol2qm74	6741	26	radical	radical	JJ
cord-015021-pol2qm74	6741	27	injury	injury	NN
cord-015021-pol2qm74	6741	28	during	during	IN
cord-015021-pol2qm74	6741	29	the	the	DT
cord-015021-pol2qm74	6741	30	ischemia	ischemia	NN
cord-015021-pol2qm74	6741	31	/	/	SYM
cord-015021-pol2qm74	6741	32	reperfi	reperfi	NNP
cord-015021-pol2qm74	6741	33	~	~	NFP
cord-015021-pol2qm74	6741	34	ion	ion	NN
cord-015021-pol2qm74	6741	35	syndrome	syndrome	NN
cord-015021-pol2qm74	6741	36	induced	induce	VBN
cord-015021-pol2qm74	6741	37	by	by	IN
cord-015021-pol2qm74	6741	38	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	6741	39	shock	shock	NN
cord-015021-pol2qm74	6741	40	.	.	.
cord-015021-pol2qm74	6742	1	Methods	method	NNS
cord-015021-pol2qm74	6742	2	.	.	.
cord-015021-pol2qm74	6743	1	Female	Female	NNP
cord-015021-pol2qm74	6743	2	LEWIS	LEWIS	NNP
cord-015021-pol2qm74	6743	3	rats	rat	NNS
cord-015021-pol2qm74	6743	4	(	(	-LRB-
cord-015021-pol2qm74	6743	5	190	190	CD
cord-015021-pol2qm74	6743	6	-	-	SYM
cord-015021-pol2qm74	6743	7	215	215	CD
cord-015021-pol2qm74	6743	8	g	g	NN
cord-015021-pol2qm74	6743	9	,	,	,
cord-015021-pol2qm74	6743	10	n>6	n>6	NNP
cord-015021-pol2qm74	6743	11	;	;	,
cord-015021-pol2qm74	6743	12	pentobarbital	pentobarbital	NN
cord-015021-pol2qm74	6743	13	anesthesia	anesthesia	NN
cord-015021-pol2qm74	6743	14	50	50	CD
cord-015021-pol2qm74	6743	15	mgjkg	mgjkg	NN
cord-015021-pol2qm74	6743	16	)	)	-RRB-
cord-015021-pol2qm74	6743	17	,	,	,
cord-015021-pol2qm74	6743	18	in	in	IN
cord-015021-pol2qm74	6743	19	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	6743	20	shock	shock	NN
cord-015021-pol2qm74	6743	21	(	(	-LRB-
cord-015021-pol2qm74	6743	22	The	the	DT
cord-015021-pol2qm74	6743	23	aim	aim	NN
cord-015021-pol2qm74	6743	24	of	of	IN
cord-015021-pol2qm74	6743	25	the	the	DT
cord-015021-pol2qm74	6743	26	study	study	NN
cord-015021-pol2qm74	6743	27	was	be	VBD
cord-015021-pol2qm74	6743	28	to	to	TO
cord-015021-pol2qm74	6743	29	elucidate	elucidate	VB
cord-015021-pol2qm74	6743	30	(	(	-LRB-
cord-015021-pol2qm74	6743	31	1	1	CD
cord-015021-pol2qm74	6743	32	)	)	-RRB-
cord-015021-pol2qm74	6743	33	whether	whether	IN
cord-015021-pol2qm74	6743	34	the	the	DT
cord-015021-pol2qm74	6743	35	generation	generation	NN
cord-015021-pol2qm74	6743	36	of	of	IN
cord-015021-pol2qm74	6743	37	OR	or	CC
cord-015021-pol2qm74	6743	38	would	would	MD
cord-015021-pol2qm74	6743	39	affect	affect	VB
cord-015021-pol2qm74	6743	40	lung	lung	NN
cord-015021-pol2qm74	6743	41	and	and	CC
cord-015021-pol2qm74	6743	42	kidneys	kidney	NNS
cord-015021-pol2qm74	6743	43	as	as	IN
cord-015021-pol2qm74	6743	44	primary	primary	JJ
cord-015021-pol2qm74	6743	45	shock	shock	NN
cord-015021-pol2qm74	6743	46	organs	organ	NNS
cord-015021-pol2qm74	6743	47	in	in	IN
cord-015021-pol2qm74	6743	48	the	the	DT
cord-015021-pol2qm74	6743	49	very	very	RB
cord-015021-pol2qm74	6743	50	early	early	JJ
cord-015021-pol2qm74	6743	51	phase	phase	NN
cord-015021-pol2qm74	6743	52	of	of	IN
cord-015021-pol2qm74	6743	53	sepsis	sepsis	NN
cord-015021-pol2qm74	6743	54	and	and	CC
cord-015021-pol2qm74	6743	55	(	(	-LRB-
cord-015021-pol2qm74	6743	56	2	2	LS
cord-015021-pol2qm74	6743	57	)	)	-RRB-
cord-015021-pol2qm74	6743	58	whether	whether	IN
cord-015021-pol2qm74	6743	59	DFO	DFO	NNP
cord-015021-pol2qm74	6743	60	-	-	HYPH
cord-015021-pol2qm74	6743	61	HES	HES	NNP
cord-015021-pol2qm74	6743	62	could	could	MD
cord-015021-pol2qm74	6743	63	prevent	prevent	VB
cord-015021-pol2qm74	6743	64	this	this	DT
cord-015021-pol2qm74	6743	65	tissue	tissue	NN
cord-015021-pol2qm74	6743	66	damage	damage	NN
cord-015021-pol2qm74	6743	67	.	.	.
cord-015021-pol2qm74	6744	1	Methods	method	NNS
cord-015021-pol2qm74	6744	2	:	:	:
cord-015021-pol2qm74	6744	3	In	in	IN
cord-015021-pol2qm74	6744	4	67	67	CD
cord-015021-pol2qm74	6744	5	rats	rat	NNS
cord-015021-pol2qm74	6744	6	sepsis	sepsis	NN
cord-015021-pol2qm74	6744	7	was	be	VBD
cord-015021-pol2qm74	6744	8	induced	induce	VBN
cord-015021-pol2qm74	6744	9	by	by	IN
cord-015021-pol2qm74	6744	10	cecal	cecal	JJ
cord-015021-pol2qm74	6744	11	ligation	ligation	NN
cord-015021-pol2qm74	6744	12	puncture	puncture	NN
cord-015021-pol2qm74	6744	13	(	(	-LRB-
cord-015021-pol2qm74	6744	14	CLP	CLP	NNP
cord-015021-pol2qm74	6744	15	)	)	-RRB-
cord-015021-pol2qm74	6744	16	peritonitis	peritonitis	NN
cord-015021-pol2qm74	6744	17	.	.	.
cord-015021-pol2qm74	6745	1	The	the	DT
cord-015021-pol2qm74	6745	2	animals	animal	NNS
cord-015021-pol2qm74	6745	3	were	be	VBD
cord-015021-pol2qm74	6745	4	randomly	randomly	RB
cord-015021-pol2qm74	6745	5	assessed	assess	VBN
cord-015021-pol2qm74	6745	6	to	to	IN
cord-015021-pol2qm74	6745	7	2	2	CD
cord-015021-pol2qm74	6745	8	groups	group	NNS
cord-015021-pol2qm74	6745	9	:	:	:
cord-015021-pol2qm74	6745	10	one	one	CD
cord-015021-pol2qm74	6745	11	group	group	NN
cord-015021-pol2qm74	6745	12	was	be	VBD
cord-015021-pol2qm74	6745	13	treated	treat	VBN
cord-015021-pol2qm74	6745	14	with	with	IN
cord-015021-pol2qm74	6745	15	3	3	CD
cord-015021-pol2qm74	6745	16	ml	ml	NN
cord-015021-pol2qm74	6745	17	DFO	DFO	NNP
cord-015021-pol2qm74	6745	18	-	-	HYPH
cord-015021-pol2qm74	6745	19	HES	HES	NNP
cord-015021-pol2qm74	6746	1	(	(	-LRB-
cord-015021-pol2qm74	6746	2	100	100	CD
cord-015021-pol2qm74	6746	3	mg	mg	NNP
cord-015021-pol2qm74	6746	4	/	/	SYM
cord-015021-pol2qm74	6746	5	kg	kg	NNP
cord-015021-pol2qm74	6746	6	iv	iv	CD
cord-015021-pol2qm74	6746	7	)	)	-RRB-
cord-015021-pol2qm74	6746	8	,	,	,
cord-015021-pol2qm74	6746	9	the	the	DT
cord-015021-pol2qm74	6746	10	other	other	JJ
cord-015021-pol2qm74	6746	11	rats	rat	NNS
cord-015021-pol2qm74	6746	12	received	receive	VBD
cord-015021-pol2qm74	6746	13	solely	solely	RB
cord-015021-pol2qm74	6746	14	3	3	CD
cord-015021-pol2qm74	6746	15	ml	ml	NNS
cord-015021-pol2qm74	6746	16	of	of	IN
cord-015021-pol2qm74	6746	17	the	the	DT
cord-015021-pol2qm74	6746	18	carrier	carrier	NN
cord-015021-pol2qm74	6746	19	starch	starch	NN
cord-015021-pol2qm74	6746	20	solution	solution	NN
cord-015021-pol2qm74	6746	21	.	.	.
cord-015021-pol2qm74	6747	1	30	30	CD
cord-015021-pol2qm74	6747	2	,	,	,
cord-015021-pol2qm74	6747	3	60	60	CD
cord-015021-pol2qm74	6747	4	,	,	,
cord-015021-pol2qm74	6747	5	120	120	CD
cord-015021-pol2qm74	6747	6	,	,	,
cord-015021-pol2qm74	6747	7	and	and	CC
cord-015021-pol2qm74	6747	8	240	240	CD
cord-015021-pol2qm74	6747	9	min	min	NN
cord-015021-pol2qm74	6747	10	after	after	IN
cord-015021-pol2qm74	6747	11	induction	induction	NN
cord-015021-pol2qm74	6747	12	of	of	IN
cord-015021-pol2qm74	6747	13	sepsis	sepsis	NN
cord-015021-pol2qm74	6748	1	respectively	respectively	RB
cord-015021-pol2qm74	6748	2	,	,	,
cord-015021-pol2qm74	6748	3	the	the	DT
cord-015021-pol2qm74	6748	4	animals	animal	NNS
cord-015021-pol2qm74	6748	5	were	be	VBD
cord-015021-pol2qm74	6748	6	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	6748	7	,	,	,
cord-015021-pol2qm74	6748	8	the	the	DT
cord-015021-pol2qm74	6748	9	organs	organ	NNS
cord-015021-pol2qm74	6748	10	collected	collect	VBN
cord-015021-pol2qm74	6748	11	,	,	,
cord-015021-pol2qm74	6748	12	and	and	CC
cord-015021-pol2qm74	6748	13	tissue	tissue	NN
cord-015021-pol2qm74	6748	14	contents	content	NNS
cord-015021-pol2qm74	6748	15	of	of	IN
cord-015021-pol2qm74	6748	16	glutathione	glutathione	NN
cord-015021-pol2qm74	6748	17	(	(	-LRB-
cord-015021-pol2qm74	6748	18	GSH	GSH	NNP
cord-015021-pol2qm74	6748	19	)	)	-RRB-
cord-015021-pol2qm74	6748	20	,	,	,
cord-015021-pol2qm74	6748	21	malondialdehyde	malondialdehyde	NNP
cord-015021-pol2qm74	6748	22	(	(	-LRB-
cord-015021-pol2qm74	6748	23	MDA	MDA	NNP
cord-015021-pol2qm74	6748	24	)	)	-RRB-
cord-015021-pol2qm74	6748	25	,	,	,
cord-015021-pol2qm74	6748	26	myeloperoxidase	myeloperoxidase	NNP
cord-015021-pol2qm74	6748	27	(	(	-LRB-
cord-015021-pol2qm74	6748	28	MPO	MPO	NNP
cord-015021-pol2qm74	6748	29	)	)	-RRB-
cord-015021-pol2qm74	6748	30	and	and	CC
cord-015021-pol2qm74	6748	31	conjugated	conjugate	VBN
cord-015021-pol2qm74	6748	32	dienes	diene	NNS
cord-015021-pol2qm74	6748	33	(	(	-LRB-
cord-015021-pol2qm74	6748	34	CD	CD	NNP
cord-015021-pol2qm74	6748	35	)	)	-RRB-
cord-015021-pol2qm74	6748	36	determined	determine	VBD
cord-015021-pol2qm74	6748	37	.	.	.
cord-015021-pol2qm74	6749	1	Plasma	plasma	NN
cord-015021-pol2qm74	6749	2	samples	sample	NNS
cord-015021-pol2qm74	6749	3	were	be	VBD
cord-015021-pol2qm74	6749	4	obtained	obtain	VBN
cord-015021-pol2qm74	6749	5	for	for	IN
cord-015021-pol2qm74	6749	6	analyses	analysis	NNS
cord-015021-pol2qm74	6749	7	of	of	IN
cord-015021-pol2qm74	6749	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6749	9	(	(	-LRB-
cord-015021-pol2qm74	6749	10	chromogenic	chromogenic	NNP
cord-015021-pol2qm74	6749	11	LAL	LAL	NNP
cord-015021-pol2qm74	6749	12	test	test	NN
cord-015021-pol2qm74	6749	13	)	)	-RRB-
cord-015021-pol2qm74	6749	14	.	.	.
cord-015021-pol2qm74	6750	1	Blood	blood	NN
cord-015021-pol2qm74	6750	2	pressure	pressure	NN
cord-015021-pol2qm74	6750	3	(	(	-LRB-
cord-015021-pol2qm74	6750	4	MAP	MAP	NNP
cord-015021-pol2qm74	6750	5	)	)	-RRB-
cord-015021-pol2qm74	6750	6	was	be	VBD
cord-015021-pol2qm74	6750	7	measured	measure	VBN
cord-015021-pol2qm74	6750	8	via	via	IN
cord-015021-pol2qm74	6750	9	a	a	DT
cord-015021-pol2qm74	6750	10	carotid	carotid	JJ
cord-015021-pol2qm74	6750	11	artery	artery	NN
cord-015021-pol2qm74	6750	12	catheter	catheter	NN
cord-015021-pol2qm74	6750	13	.	.	.
cord-015021-pol2qm74	6751	1	Results	result	NNS
cord-015021-pol2qm74	6751	2	:	:	:
cord-015021-pol2qm74	6752	1	CLP	CLP	NNP
cord-015021-pol2qm74	6752	2	caused	cause	VBD
cord-015021-pol2qm74	6752	3	sepsis	sepsis	NN
cord-015021-pol2qm74	6752	4	with	with	IN
cord-015021-pol2qm74	6752	5	high	high	JJ
cord-015021-pol2qm74	6752	6	(	(	-LRB-
cord-015021-pol2qm74	6752	7	>	>	NFP
cord-015021-pol2qm74	6752	8	1.84	1.84	CD
cord-015021-pol2qm74	6752	9	EU	EU	NNP
cord-015021-pol2qm74	6752	10	/	/	SYM
cord-015021-pol2qm74	6752	11	ml	ml	NN
cord-015021-pol2qm74	6752	12	)	)	-RRB-
cord-015021-pol2qm74	6752	13	endotoxin	endotoxin	NN
cord-015021-pol2qm74	6752	14	levels	level	NNS
cord-015021-pol2qm74	6752	15	.	.	.
cord-015021-pol2qm74	6753	1	MAP	map	VB
cord-015021-pol2qm74	6753	2	in	in	IN
cord-015021-pol2qm74	6753	3	both	both	DT
cord-015021-pol2qm74	6753	4	groups	group	NNS
cord-015021-pol2qm74	6753	5	decreased	decrease	VBD
cord-015021-pol2qm74	6753	6	slightly	slightly	RB
cord-015021-pol2qm74	6753	7	but	but	CC
cord-015021-pol2qm74	6753	8	significantly	significantly	RB
cord-015021-pol2qm74	6753	9	during	during	IN
cord-015021-pol2qm74	6753	10	sepsis	sepsis	NN
cord-015021-pol2qm74	6753	11	regardless	regardless	RB
cord-015021-pol2qm74	6753	12	any	any	DT
cord-015021-pol2qm74	6753	13	treatment	treatment	NN
cord-015021-pol2qm74	6753	14	.	.	.
cord-015021-pol2qm74	6754	1	In	in	IN
cord-015021-pol2qm74	6754	2	the	the	DT
cord-015021-pol2qm74	6754	3	lungs	lung	NNS
cord-015021-pol2qm74	6754	4	MPO	MPO	NNP
cord-015021-pol2qm74	6754	5	concentration	concentration	NN
cord-015021-pol2qm74	6754	6	was	be	VBD
cord-015021-pol2qm74	6754	7	increased	increase	VBN
cord-015021-pol2qm74	6754	8	(	(	-LRB-
cord-015021-pol2qm74	6754	9	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6754	10	)	)	-RRB-
cord-015021-pol2qm74	6754	11	in	in	IN
cord-015021-pol2qm74	6754	12	the	the	DT
cord-015021-pol2qm74	6754	13	lIES	lIES	NNP
cord-015021-pol2qm74	6754	14	group	group	NN
cord-015021-pol2qm74	6754	15	already	already	RB
cord-015021-pol2qm74	6754	16	30	30	CD
cord-015021-pol2qm74	6754	17	min	min	NN
cord-015021-pol2qm74	6754	18	after	after	IN
cord-015021-pol2qm74	6754	19	sepsis	sepsis	NN
cord-015021-pol2qm74	6754	20	induction	induction	NN
cord-015021-pol2qm74	6754	21	.	.	.
cord-015021-pol2qm74	6755	1	Concomitantly	concomitantly	RB
cord-015021-pol2qm74	6755	2	,	,	,
cord-015021-pol2qm74	6755	3	tissue	tissue	NN
cord-015021-pol2qm74	6755	4	GSH	GSH	NNP
cord-015021-pol2qm74	6755	5	level	level	NN
cord-015021-pol2qm74	6755	6	decreased	decrease	VBD
cord-015021-pol2qm74	6755	7	and	and	CC
cord-015021-pol2qm74	6755	8	lipid	lipid	NN
cord-015021-pol2qm74	6755	9	peroxidation	peroxidation	NN
cord-015021-pol2qm74	6755	10	was	be	VBD
cord-015021-pol2qm74	6755	11	pronounced	pronounce	VBN
cord-015021-pol2qm74	6755	12	as	as	IN
cord-015021-pol2qm74	6755	13	shown	show	VBN
cord-015021-pol2qm74	6755	14	by	by	IN
cord-015021-pol2qm74	6755	15	elevated	elevated	JJ
cord-015021-pol2qm74	6755	16	MDA	MDA	NNP
cord-015021-pol2qm74	6755	17	and	and	CC
cord-015021-pol2qm74	6755	18	CD	CD	NNP
cord-015021-pol2qm74	6755	19	levels	level	NNS
cord-015021-pol2qm74	6755	20	.	.	.
cord-015021-pol2qm74	6756	1	DFO	DFO	NNP
cord-015021-pol2qm74	6756	2	-	-	HYPH
cord-015021-pol2qm74	6756	3	HES	HES	NNP
cord-015021-pol2qm74	6756	4	diminished	diminish	VBD
cord-015021-pol2qm74	6756	5	tissue	tissue	NN
cord-015021-pol2qm74	6756	6	PMN	pmn	NN
cord-015021-pol2qm74	6756	7	accumulation	accumulation	NN
cord-015021-pol2qm74	6756	8	and	and	CC
cord-015021-pol2qm74	6756	9	MPO	MPO	NNP
cord-015021-pol2qm74	6756	10	concentration	concentration	NN
cord-015021-pol2qm74	6756	11	.	.	.
cord-015021-pol2qm74	6757	1	Moreover	moreover	RB
cord-015021-pol2qm74	6757	2	,	,	,
cord-015021-pol2qm74	6757	3	at	at	IN
cord-015021-pol2qm74	6757	4	each	each	DT
cord-015021-pol2qm74	6757	5	time	time	NN
cord-015021-pol2qm74	6757	6	point	point	NN
cord-015021-pol2qm74	6757	7	lung	lung	NN
cord-015021-pol2qm74	6757	8	MDA	MDA	NNP
cord-015021-pol2qm74	6757	9	and	and	CC
cord-015021-pol2qm74	6757	10	CD	CD	NNP
cord-015021-pol2qm74	6757	11	levels	level	NNS
cord-015021-pol2qm74	6757	12	were	be	VBD
cord-015021-pol2qm74	6757	13	lower	low	JJR
cord-015021-pol2qm74	6757	14	(	(	-LRB-
cord-015021-pol2qm74	6757	15	p<0.02	p<0.02	NN
cord-015021-pol2qm74	6757	16	)	)	-RRB-
cord-015021-pol2qm74	6757	17	.	.	.
cord-015021-pol2qm74	6758	1	Histomorphological	histomorphological	JJ
cord-015021-pol2qm74	6758	2	examination	examination	NN
cord-015021-pol2qm74	6758	3	showed	show	VBD
cord-015021-pol2qm74	6758	4	marked	mark	VBN
cord-015021-pol2qm74	6758	5	micro	micro	NN
cord-015021-pol2qm74	6758	6	-	-	HYPH
cord-015021-pol2qm74	6758	7	atelectases	atelectase	NNS
cord-015021-pol2qm74	6758	8	,	,	,
cord-015021-pol2qm74	6758	9	destruction	destruction	NN
cord-015021-pol2qm74	6758	10	of	of	IN
cord-015021-pol2qm74	6758	11	the	the	DT
cord-015021-pol2qm74	6758	12	alveolar	alveolar	JJ
cord-015021-pol2qm74	6758	13	septa	septa	NNP
cord-015021-pol2qm74	6758	14	,	,	,
cord-015021-pol2qm74	6758	15	and	and	CC
cord-015021-pol2qm74	6758	16	splicing	splicing	NN
cord-015021-pol2qm74	6758	17	of	of	IN
cord-015021-pol2qm74	6758	18	the	the	DT
cord-015021-pol2qm74	6758	19	basal	basal	NN
cord-015021-pol2qm74	6758	20	membranes	membrane	NNS
cord-015021-pol2qm74	6758	21	in	in	IN
cord-015021-pol2qm74	6758	22	the	the	DT
cord-015021-pol2qm74	6758	23	lIES	lies	JJ
cord-015021-pol2qm74	6758	24	group	group	NN
cord-015021-pol2qm74	6758	25	.	.	.
cord-015021-pol2qm74	6759	1	In	in	IN
cord-015021-pol2qm74	6759	2	contrast	contrast	NN
cord-015021-pol2qm74	6759	3	,	,	,
cord-015021-pol2qm74	6759	4	in	in	IN
cord-015021-pol2qm74	6759	5	DFO	DFO	NNP
cord-015021-pol2qm74	6759	6	-	-	HYPH
cord-015021-pol2qm74	6759	7	HES	HES	NNP
cord-015021-pol2qm74	6759	8	treated	treat	VBD
cord-015021-pol2qm74	6759	9	rats	rat	NNS
cord-015021-pol2qm74	6759	10	the	the	DT
cord-015021-pol2qm74	6759	11	alveoli	alveolus	NNS
cord-015021-pol2qm74	6759	12	remained	remain	VBD
cord-015021-pol2qm74	6759	13	well	well	RB
cord-015021-pol2qm74	6759	14	-	-	HYPH
cord-015021-pol2qm74	6759	15	ventiIated	ventiiate	VBN
cord-015021-pol2qm74	6759	16	and	and	CC
cord-015021-pol2qm74	6759	17	only	only	RB
cord-015021-pol2qm74	6759	18	some	some	DT
cord-015021-pol2qm74	6759	19	enlarged	enlarged	JJ
cord-015021-pol2qm74	6759	20	reticular	reticular	JJ
cord-015021-pol2qm74	6759	21	fibers	fiber	NNS
cord-015021-pol2qm74	6759	22	without	without	IN
cord-015021-pol2qm74	6759	23	splicing	splicing	NN
cord-015021-pol2qm74	6759	24	were	be	VBD
cord-015021-pol2qm74	6759	25	observed	observe	VBN
cord-015021-pol2qm74	6759	26	.	.	.
cord-015021-pol2qm74	6760	1	Almost	almost	RB
cord-015021-pol2qm74	6760	2	similar	similar	JJ
cord-015021-pol2qm74	6760	3	results	result	NNS
cord-015021-pol2qm74	6760	4	were	be	VBD
cord-015021-pol2qm74	6760	5	found	find	VBN
cord-015021-pol2qm74	6760	6	for	for	IN
cord-015021-pol2qm74	6760	7	the	the	DT
cord-015021-pol2qm74	6760	8	kidneys	kidney	NNS
cord-015021-pol2qm74	6760	9	.	.	.
cord-015021-pol2qm74	6761	1	MPO	MPO	NNP
cord-015021-pol2qm74	6761	2	levels	level	NNS
cord-015021-pol2qm74	6761	3	differed	differ	VBD
cord-015021-pol2qm74	6761	4	neither	neither	CC
cord-015021-pol2qm74	6761	5	within	within	IN
cord-015021-pol2qm74	6761	6	nor	nor	CC
cord-015021-pol2qm74	6761	7	between	between	IN
cord-015021-pol2qm74	6761	8	both	both	DT
cord-015021-pol2qm74	6761	9	groups	group	NNS
cord-015021-pol2qm74	6761	10	.	.	.
cord-015021-pol2qm74	6762	1	The	the	DT
cord-015021-pol2qm74	6762	2	slight	slight	JJ
cord-015021-pol2qm74	6762	3	decrease	decrease	NN
cord-015021-pol2qm74	6762	4	in	in	IN
cord-015021-pol2qm74	6762	5	GSH	GSH	NNP
cord-015021-pol2qm74	6762	6	levels	level	NNS
cord-015021-pol2qm74	6762	7	seen	see	VBN
cord-015021-pol2qm74	6762	8	after	after	IN
cord-015021-pol2qm74	6762	9	60	60	CD
cord-015021-pol2qm74	6762	10	min	min	NN
cord-015021-pol2qm74	6762	11	in	in	IN
cord-015021-pol2qm74	6762	12	the	the	DT
cord-015021-pol2qm74	6762	13	DFO	DFO	NNP
cord-015021-pol2qm74	6762	14	-	-	HYPH
cord-015021-pol2qm74	6762	15	HES	HES	NNP
cord-015021-pol2qm74	6762	16	group	group	NN
cord-015021-pol2qm74	6762	17	seems	seem	VBZ
cord-015021-pol2qm74	6762	18	to	to	TO
cord-015021-pol2qm74	6762	19	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6762	20	an	an	DT
cord-015021-pol2qm74	6762	21	oxidative	oxidative	JJ
cord-015021-pol2qm74	6762	22	stress	stress	NN
cord-015021-pol2qm74	6762	23	to	to	IN
cord-015021-pol2qm74	6762	24	a	a	DT
cord-015021-pol2qm74	6762	25	lesser	less	JJR
cord-015021-pol2qm74	6762	26	degree	degree	NN
cord-015021-pol2qm74	6762	27	.	.	.
cord-015021-pol2qm74	6763	1	The	the	DT
cord-015021-pol2qm74	6763	2	most	most	RBS
cord-015021-pol2qm74	6763	3	impressive	impressive	JJ
cord-015021-pol2qm74	6763	4	effect	effect	NN
cord-015021-pol2qm74	6763	5	of	of	IN
cord-015021-pol2qm74	6763	6	iron	iron	NN
cord-015021-pol2qm74	6763	7	chelation	chelation	NN
cord-015021-pol2qm74	6763	8	,	,	,
cord-015021-pol2qm74	6763	9	however	however	RB
cord-015021-pol2qm74	6763	10	,	,	,
cord-015021-pol2qm74	6763	11	was	be	VBD
cord-015021-pol2qm74	6763	12	revealed	reveal	VBN
cord-015021-pol2qm74	6763	13	by	by	IN
cord-015021-pol2qm74	6763	14	the	the	DT
cord-015021-pol2qm74	6763	15	lipid	lipid	NN
cord-015021-pol2qm74	6763	16	peroxidation	peroxidation	NN
cord-015021-pol2qm74	6763	17	products	product	NNS
cord-015021-pol2qm74	6763	18	.	.	.
cord-015021-pol2qm74	6764	1	At	at	IN
cord-015021-pol2qm74	6764	2	each	each	DT
cord-015021-pol2qm74	6764	3	time	time	NN
cord-015021-pol2qm74	6764	4	point	point	NN
cord-015021-pol2qm74	6764	5	,	,	,
cord-015021-pol2qm74	6764	6	MDA	MDA	NNP
cord-015021-pol2qm74	6764	7	and	and	CC
cord-015021-pol2qm74	6764	8	CD	CD	NNP
cord-015021-pol2qm74	6764	9	levels	level	NNS
cord-015021-pol2qm74	6764	10	were	be	VBD
cord-015021-pol2qm74	6764	11	lower	low	JJR
cord-015021-pol2qm74	6764	12	(	(	-LRB-
cord-015021-pol2qm74	6764	13	p<0.02	p<0.02	NN
cord-015021-pol2qm74	6764	14	)	)	-RRB-
cord-015021-pol2qm74	6764	15	compared	compare	VBN
cord-015021-pol2qm74	6764	16	to	to	IN
cord-015021-pol2qm74	6764	17	the	the	DT
cord-015021-pol2qm74	6764	18	HES	HES	NNP
cord-015021-pol2qm74	6764	19	group	group	NN
cord-015021-pol2qm74	6764	20	.	.	.
cord-015021-pol2qm74	6765	1	Light	light	NN
cord-015021-pol2qm74	6765	2	and	and	CC
cord-015021-pol2qm74	6765	3	electron	electron	NN
cord-015021-pol2qm74	6765	4	microscopic	microscopic	JJ
cord-015021-pol2qm74	6765	5	examination	examination	NN
cord-015021-pol2qm74	6765	6	disclosed	disclose	VBD
cord-015021-pol2qm74	6765	7	tubulotoxic	tubulotoxic	NNP
cord-015021-pol2qm74	6765	8	and	and	CC
cord-015021-pol2qm74	6765	9	mitochondriat	mitochondriat	NNP
cord-015021-pol2qm74	6765	10	damages	damage	NNS
cord-015021-pol2qm74	6765	11	while	while	IN
cord-015021-pol2qm74	6765	12	DFO	DFO	NNP
cord-015021-pol2qm74	6765	13	-	-	HYPH
cord-015021-pol2qm74	6765	14	HES	HES	NNP
cord-015021-pol2qm74	6765	15	lxeatment	lxeatment	NN
cord-015021-pol2qm74	6765	16	prevented	prevent	VBD
cord-015021-pol2qm74	6765	17	that	that	IN
cord-015021-pol2qm74	6765	18	alterations	alteration	NNS
cord-015021-pol2qm74	6765	19	.	.	.
cord-015021-pol2qm74	6766	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	6766	2	:	:	:
cord-015021-pol2qm74	6766	3	Both	both	CC
cord-015021-pol2qm74	6766	4	the	the	DT
cord-015021-pol2qm74	6766	5	biochemical	biochemical	JJ
cord-015021-pol2qm74	6766	6	and	and	CC
cord-015021-pol2qm74	6766	7	histological	histological	JJ
cord-015021-pol2qm74	6766	8	results	result	NNS
cord-015021-pol2qm74	6766	9	of	of	IN
cord-015021-pol2qm74	6766	10	this	this	DT
cord-015021-pol2qm74	6766	11	study	study	NN
cord-015021-pol2qm74	6766	12	reveal	reveal	VBP
cord-015021-pol2qm74	6766	13	an	an	DT
cord-015021-pol2qm74	6766	14	early	early	JJ
cord-015021-pol2qm74	6766	15	and	and	CC
cord-015021-pol2qm74	6766	16	remarkable	remarkable	JJ
cord-015021-pol2qm74	6766	17	generation	generation	NN
cord-015021-pol2qm74	6766	18	of	of	IN
cord-015021-pol2qm74	6766	19	OR	or	CC
cord-015021-pol2qm74	6766	20	in	in	IN
cord-015021-pol2qm74	6766	21	peritonitis	peritonitis	NN
cord-015021-pol2qm74	6766	22	-	-	HYPH
cord-015021-pol2qm74	6766	23	induced	induce	VBN
cord-015021-pol2qm74	6766	24	sepsis	sepsis	NN
cord-015021-pol2qm74	6766	25	.	.	.
cord-015021-pol2qm74	6767	1	Thereby	thereby	RB
cord-015021-pol2qm74	6767	2	,	,	,
cord-015021-pol2qm74	6767	3	these	these	DT
cord-015021-pol2qm74	6767	4	OR	or	CC
cord-015021-pol2qm74	6767	5	obviously	obviously	RB
cord-015021-pol2qm74	6767	6	cause	cause	VB
cord-015021-pol2qm74	6767	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	6767	8	and	and	CC
cord-015021-pol2qm74	6767	9	renal	renal	JJ
cord-015021-pol2qm74	6767	10	tissue	tissue	NN
cord-015021-pol2qm74	6767	11	damages	damage	NNS
cord-015021-pol2qm74	6767	12	,	,	,
cord-015021-pol2qm74	6767	13	intravenous	intravenous	JJ
cord-015021-pol2qm74	6767	14	application	application	NN
cord-015021-pol2qm74	6767	15	of	of	IN
cord-015021-pol2qm74	6767	16	DFO	DFO	NNP
cord-015021-pol2qm74	6767	17	-	-	HYPH
cord-015021-pol2qm74	6767	18	HES	HES	NNP
cord-015021-pol2qm74	6767	19	may	may	MD
cord-015021-pol2qm74	6767	20	,	,	,
cord-015021-pol2qm74	6767	21	however	however	RB
cord-015021-pol2qm74	6767	22	,	,	,
cord-015021-pol2qm74	6767	23	benefit	benefit	VBP
cord-015021-pol2qm74	6767	24	by	by	IN
cord-015021-pol2qm74	6767	25	preventing	prevent	VBG
cord-015021-pol2qm74	6767	26	early	early	JJ
cord-015021-pol2qm74	6767	27	lipid	lipid	NN
cord-015021-pol2qm74	6767	28	peroxidation	peroxidation	NN
cord-015021-pol2qm74	6767	29	of	of	IN
cord-015021-pol2qm74	6767	30	the	the	DT
cord-015021-pol2qm74	6767	31	tissue	tissue	NN
cord-015021-pol2qm74	6767	32	.	.	.
cord-015021-pol2qm74	6768	1	The	the	DT
cord-015021-pol2qm74	6768	2	proteolytic	proteolytic	JJ
cord-015021-pol2qm74	6768	3	irreversible	irreversible	JJ
cord-015021-pol2qm74	6768	4	COnversion	conversion	NN
cord-015021-pol2qm74	6768	5	of	of	IN
cord-015021-pol2qm74	6768	6	xanthine	xanthine	NN
cord-015021-pol2qm74	6768	7	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	6768	8	(	(	-LRB-
cord-015021-pol2qm74	6768	9	XD	XD	NNP
cord-015021-pol2qm74	6768	10	)	)	-RRB-
cord-015021-pol2qm74	6768	11	to	to	IN
cord-015021-pol2qm74	6768	12	xanthine	xanthine	NN
cord-015021-pol2qm74	6768	13	Oxidase	Oxidase	NNP
cord-015021-pol2qm74	6768	14	(	(	-LRB-
cord-015021-pol2qm74	6768	15	XO	XO	NNP
cord-015021-pol2qm74	6768	16	)	)	-RRB-
cord-015021-pol2qm74	6768	17	is	be	VBZ
cord-015021-pol2qm74	6768	18	triggered	trigger	VBN
cord-015021-pol2qm74	6768	19	by	by	IN
cord-015021-pol2qm74	6768	20	calcium	calcium	NN
cord-015021-pol2qm74	6768	21	flux	flux	NN
cord-015021-pol2qm74	6768	22	.	.	.
cord-015021-pol2qm74	6769	1	The	the	DT
cord-015021-pol2qm74	6769	2	aim	aim	NN
cord-015021-pol2qm74	6769	3	of	of	IN
cord-015021-pol2qm74	6769	4	our	-PRON-	PRP$
cord-015021-pol2qm74	6769	5	study	study	NN
cord-015021-pol2qm74	6769	6	is	be	VBZ
cord-015021-pol2qm74	6769	7	to	to	TO
cord-015021-pol2qm74	6769	8	clarify	clarify	VB
cord-015021-pol2qm74	6769	9	~he	~he	NNP
cord-015021-pol2qm74	6769	10	link	link	VB
cord-015021-pol2qm74	6769	11	between	between	IN
cord-015021-pol2qm74	6769	12	intracellular	intracellular	JJ
cord-015021-pol2qm74	6769	13	Ca2	ca2	CD
cord-015021-pol2qm74	6769	14	+	+	SYM
cord-015021-pol2qm74	6769	15	levels	level	NNS
cord-015021-pol2qm74	6769	16	and	and	CC
cord-015021-pol2qm74	6769	17	XO	XO	NNP
cord-015021-pol2qm74	6769	18	activity	activity	NN
cord-015021-pol2qm74	6769	19	determined	determine	VBN
cord-015021-pol2qm74	6769	20	by	by	IN
cord-015021-pol2qm74	6769	21	uric	uric	NN
cord-015021-pol2qm74	6769	22	acid	acid	NN
cord-015021-pol2qm74	6769	23	release	release	NN
cord-015021-pol2qm74	6769	24	,	,	,
cord-015021-pol2qm74	6769	25	and	and	CC
cord-015021-pol2qm74	6769	26	to	to	TO
cord-015021-pol2qm74	6769	27	evaluate	evaluate	VB
cord-015021-pol2qm74	6769	28	the	the	DT
cord-015021-pol2qm74	6769	29	efficacy	efficacy	NN
cord-015021-pol2qm74	6769	30	of	of	IN
cord-015021-pol2qm74	6769	31	verapamil	verapamil	NN
cord-015021-pol2qm74	6769	32	,	,	,
cord-015021-pol2qm74	6769	33	on	on	IN
cord-015021-pol2qm74	6769	34	the	the	DT
cord-015021-pol2qm74	6769	35	generation	generation	NN
cord-015021-pol2qm74	6769	36	of	of	IN
cord-015021-pol2qm74	6769	37	hydrogen	hydrogen	NN
cord-015021-pol2qm74	6769	38	peroxide	peroxide	NN
cord-015021-pol2qm74	6769	39	associated	associate	VBN
cord-015021-pol2qm74	6769	40	with	with	IN
cord-015021-pol2qm74	6769	41	reperfusion	reperfusion	NN
cord-015021-pol2qm74	6769	42	by	by	IN
cord-015021-pol2qm74	6769	43	assaying	assay	VBG
cord-015021-pol2qm74	6769	44	lactate	lactate	NN
cord-015021-pol2qm74	6769	45	&	&	CC
cord-015021-pol2qm74	6769	46	pyruva	pyruva	NNP
cord-015021-pol2qm74	6769	47	~	~	NFP
cord-015021-pol2qm74	6769	48	e	e	NN
cord-015021-pol2qm74	6769	49	release	release	NN
cord-015021-pol2qm74	6769	50	and	and	CC
cord-015021-pol2qm74	6769	51	the	the	DT
cord-015021-pol2qm74	6769	52	levels	level	NNS
cord-015021-pol2qm74	6769	53	of	of	IN
cord-015021-pol2qm74	6769	54	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	6769	55	free	free	JJ
cord-015021-pol2qm74	6769	56	NAD	NAD	NNP
cord-015021-pol2qm74	6769	57	/NADH	/NADH	:
cord-015021-pol2qm74	6769	58	ratio	ratio	NN
cord-015021-pol2qm74	6769	59	.	.	.
cord-015021-pol2qm74	6770	1	Experimental	experimental	JJ
cord-015021-pol2qm74	6770	2	protocol	protocol	NN
cord-015021-pol2qm74	6770	3	consisted	consist	VBD
cord-015021-pol2qm74	6770	4	of	of	IN
cord-015021-pol2qm74	6770	5	:	:	:
cord-015021-pol2qm74	6770	6	(	(	-LRB-
cord-015021-pol2qm74	6770	7	A	a	NN
cord-015021-pol2qm74	6770	8	)	)	-RRB-
cord-015021-pol2qm74	6770	9	Non	non	JJ
cord-015021-pol2qm74	6770	10	ischemic	ischemic	JJ
cord-015021-pol2qm74	6770	11	/	/	SYM
cord-015021-pol2qm74	6770	12	reperfused	reperfused	JJ
cord-015021-pol2qm74	6770	13	experiment	experiment	NN
cord-015021-pol2qm74	6770	14	in	in	IN
cord-015021-pol2qm74	6770	15	which	which	WDT
cord-015021-pol2qm74	6770	16	normal	normal	JJ
cord-015021-pol2qm74	6770	17	cardiac	cardiac	JJ
cord-015021-pol2qm74	6770	18	slices	slice	NNS
cord-015021-pol2qm74	6770	19	of	of	IN
cord-015021-pol2qm74	6770	20	rats	rat	NNS
cord-015021-pol2qm74	6770	21	were	be	VBD
cord-015021-pol2qm74	6770	22	perfusated	perfusate	VBN
cord-015021-pol2qm74	6770	23	with	with	IN
cord-015021-pol2qm74	6770	24	oxygenated	oxygenated	JJ
cord-015021-pol2qm74	6770	25	kreb	kreb	NNP
cord-015021-pol2qm74	6770	26	's	's	POS
cord-015021-pol2qm74	6770	27	Ringer	Ringer	NNP
cord-015021-pol2qm74	6770	28	phosphate	phosphate	NN
cord-015021-pol2qm74	6770	29	buffer	buffer	NN
cord-015021-pol2qm74	6770	30	containing	contain	VBG
cord-015021-pol2qm74	6770	31	glucose	glucose	NN
cord-015021-pol2qm74	6770	32	(	(	-LRB-
cord-015021-pol2qm74	6770	33	150mg%	150mg%	CD
cord-015021-pol2qm74	6770	34	)	)	-RRB-
cord-015021-pol2qm74	6770	35	and	and	CC
cord-015021-pol2qm74	6770	36	bovine	bovine	JJ
cord-015021-pol2qm74	6770	37	albumine	albumine	NN
cord-015021-pol2qm74	6770	38	(	(	-LRB-
cord-015021-pol2qm74	6770	39	5gm%	5gm%	CD
cord-015021-pol2qm74	6770	40	)	)	-RRB-
cord-015021-pol2qm74	6770	41	for	for	IN
cord-015021-pol2qm74	6770	42	60min	60min	NN
cord-015021-pol2qm74	6770	43	at	at	IN
cord-015021-pol2qm74	6770	44	37	37	CD
cord-015021-pol2qm74	6770	45	°	°	NNS
cord-015021-pol2qm74	6770	46	C.It	C.It	NNP
cord-015021-pol2qm74	6770	47	composed	compose	VBN
cord-015021-pol2qm74	6770	48	of	of	IN
cord-015021-pol2qm74	6770	49	3	3	CD
cord-015021-pol2qm74	6770	50	groups	group	NNS
cord-015021-pol2qm74	6770	51	,	,	,
cord-015021-pol2qm74	6770	52	group	group	NN
cord-015021-pol2qm74	6770	53	Aa	Aa	NNP
cord-015021-pol2qm74	6770	54	(	(	-LRB-
cord-015021-pol2qm74	6770	55	control	control	NNP
cord-015021-pol2qm74	6770	56	group	group	NN
cord-015021-pol2qm74	6770	57	)	)	-RRB-
cord-015021-pol2qm74	6770	58	,	,	,
cord-015021-pol2qm74	6770	59	and	and	CC
cord-015021-pol2qm74	6770	60	groups	group	NNS
cord-015021-pol2qm74	6770	61	Ab	Ab	NNP
cord-015021-pol2qm74	6770	62	&	&	CC
cord-015021-pol2qm74	6770	63	Ac	Ac	NNP
cord-015021-pol2qm74	6770	64	(	(	-LRB-
cord-015021-pol2qm74	6770	65	perfusate	perfusate	NN
cord-015021-pol2qm74	6770	66	supplemented	supplement	VBN
cord-015021-pol2qm74	6770	67	with	with	IN
cord-015021-pol2qm74	6770	68	verapamil	verapamil	NN
cord-015021-pol2qm74	6770	69	in	in	IN
cord-015021-pol2qm74	6770	70	the	the	DT
cord-015021-pol2qm74	6770	71	dose	dose	NN
cord-015021-pol2qm74	6770	72	of	of	IN
cord-015021-pol2qm74	6770	73	lOO&200	loo&200	NN
cord-015021-pol2qm74	6770	74	mi%	mi%	NNP
cord-015021-pol2qm74	6770	75	respectively	respectively	RB
cord-015021-pol2qm74	6770	76	)	)	-RRB-
cord-015021-pol2qm74	6770	77	.	.	.
cord-015021-pol2qm74	6771	1	(	(	-LRB-
cord-015021-pol2qm74	6771	2	B	b	NN
cord-015021-pol2qm74	6771	3	)	)	-RRB-
cord-015021-pol2qm74	6772	1	Ischemic	ischemic	JJ
cord-015021-pol2qm74	6772	2	reperfused	reperfused	JJ
cord-015021-pol2qm74	6772	3	experiment	experiment	NN
cord-015021-pol2qm74	6772	4	in	in	IN
cord-015021-pol2qm74	6772	5	which	which	WDT
cord-015021-pol2qm74	6772	6	ischemic	ischemic	JJ
cord-015021-pol2qm74	6772	7	cardiac	cardiac	JJ
cord-015021-pol2qm74	6772	8	slices	slice	NNS
cord-015021-pol2qm74	6772	9	were	be	VBD
cord-015021-pol2qm74	6772	10	obtained	obtain	VBN
cord-015021-pol2qm74	6772	11	from	from	IN
cord-015021-pol2qm74	6772	12	rats	rat	NNS
cord-015021-pol2qm74	6772	13	subjected	subject	VBN
cord-015021-pol2qm74	6772	14	to	to	IN
cord-015021-pol2qm74	6772	15	15	15	CD
cord-015021-pol2qm74	6772	16	min	min	NN
cord-015021-pol2qm74	6773	1	~aemorrhage.lt	~aemorrhage.lt	JJ
cord-015021-pol2qm74	6773	2	was	be	VBD
cord-015021-pol2qm74	6773	3	also	also	RB
cord-015021-pol2qm74	6773	4	divided	divide	VBN
cord-015021-pol2qm74	6773	5	into	into	IN
cord-015021-pol2qm74	6773	6	two	two	CD
cord-015021-pol2qm74	6773	7	groups	group	NNS
cord-015021-pol2qm74	6773	8	;	;	:
cord-015021-pol2qm74	6773	9	group	group	NN
cord-015021-pol2qm74	6773	10	Ba	Ba	NNP
cord-015021-pol2qm74	6773	11	and	and	CC
cord-015021-pol2qm74	6773	12	Bb	Bb	NNP
cord-015021-pol2qm74	6773	13	(	(	-LRB-
cord-015021-pol2qm74	6773	14	verapam~/	verapam~/	``
cord-015021-pol2qm74	6773	15	200mi%	200mi%	CD
cord-015021-pol2qm74	6773	16	added	add	VBD
cord-015021-pol2qm74	6773	17	to	to	IN
cord-015021-pol2qm74	6773	18	perfusate	perfusate	VB
cord-015021-pol2qm74	6773	19	}	}	-RRB-
cord-015021-pol2qm74	6773	20	.	.	.
cord-015021-pol2qm74	6774	1	Verapamil	verapamil	NN
cord-015021-pol2qm74	6774	2	stimulated	stimulate	VBD
cord-015021-pol2qm74	6774	3	uric	uric	NN
cord-015021-pol2qm74	6774	4	acid	acid	NN
cord-015021-pol2qm74	6774	5	release	release	NN
cord-015021-pol2qm74	6774	6	from	from	IN
cord-015021-pol2qm74	6774	7	normal	normal	JJ
cord-015021-pol2qm74	6774	8	rat	rat	NN
cord-015021-pol2qm74	6774	9	cardiac	cardiac	JJ
cord-015021-pol2qm74	6774	10	slices	slice	NNS
cord-015021-pol2qm74	6774	11	were	be	VBD
cord-015021-pol2qm74	6774	12	267	267	CD
cord-015021-pol2qm74	6774	13	%	%	NN
cord-015021-pol2qm74	6774	14	in	in	IN
cord-015021-pol2qm74	6774	15	group	group	NN
cord-015021-pol2qm74	6774	16	Ab	Ab	NNP
cord-015021-pol2qm74	6774	17	and	and	CC
cord-015021-pol2qm74	6774	18	767	767	CD
cord-015021-pol2qm74	6774	19	%	%	NN
cord-015021-pol2qm74	6774	20	in	in	IN
cord-015021-pol2qm74	6774	21	group	group	NN
cord-015021-pol2qm74	6775	1	Ac(dose	ac(dose	RB
cord-015021-pol2qm74	6775	2	related	relate	VBN
cord-015021-pol2qm74	6775	3	)	)	-RRB-
cord-015021-pol2qm74	6775	4	.	.	.
cord-015021-pol2qm74	6776	1	Rates	rate	NNS
cord-015021-pol2qm74	6776	2	of	of	IN
cord-015021-pol2qm74	6776	3	uric	uric	NN
cord-015021-pol2qm74	6776	4	acid	acid	NN
cord-015021-pol2qm74	6776	5	release	release	NN
cord-015021-pol2qm74	6776	6	is	be	VBZ
cord-015021-pol2qm74	6776	7	enhanced	enhance	VBN
cord-015021-pol2qm74	6776	8	by	by	IN
cord-015021-pol2qm74	6776	9	verapamil	verapamil	NN
cord-015021-pol2qm74	6776	10	in	in	IN
cord-015021-pol2qm74	6776	11	group	group	NN
cord-015021-pol2qm74	6776	12	Bb	Bb	NNP
cord-015021-pol2qm74	6776	13	.	.	.
cord-015021-pol2qm74	6777	1	Moreover	moreover	RB
cord-015021-pol2qm74	6777	2	,	,	,
cord-015021-pol2qm74	6777	3	rates	rate	NNS
cord-015021-pol2qm74	6777	4	of	of	IN
cord-015021-pol2qm74	6777	5	uric	uric	NN
cord-015021-pol2qm74	6777	6	acid	acid	NN
cord-015021-pol2qm74	6777	7	release	release	NN
cord-015021-pol2qm74	6777	8	in	in	IN
cord-015021-pol2qm74	6777	9	groups	group	NNS
cord-015021-pol2qm74	6777	10	Ac	Ac	NNP
cord-015021-pol2qm74	6777	11	&	&	CC
cord-015021-pol2qm74	6777	12	Bb	Bb	NNP
cord-015021-pol2qm74	6777	13	are	be	VBP
cord-015021-pol2qm74	6777	14	insignificant	insignificant	JJ
cord-015021-pol2qm74	6777	15	.	.	.
cord-015021-pol2qm74	6778	1	In	in	IN
cord-015021-pol2qm74	6778	2	verapmil	verapmil	NN
cord-015021-pol2qm74	6778	3	added	add	VBD
cord-015021-pol2qm74	6778	4	groups	group	NNS
cord-015021-pol2qm74	6778	5	(	(	-LRB-
cord-015021-pol2qm74	6778	6	group	group	NN
cord-015021-pol2qm74	6778	7	Ab	Ab	NNP
cord-015021-pol2qm74	6778	8	,	,	,
cord-015021-pol2qm74	6778	9	Ac	Ac	NNP
cord-015021-pol2qm74	6778	10	&	&	CC
cord-015021-pol2qm74	6778	11	Bb	Bb	NNP
cord-015021-pol2qm74	6778	12	)	)	-RRB-
cord-015021-pol2qm74	6778	13	,	,	,
cord-015021-pol2qm74	6778	14	increase	increase	VB
cord-015021-pol2qm74	6778	15	uric	uric	NN
cord-015021-pol2qm74	6778	16	acid	acid	NN
cord-015021-pol2qm74	6778	17	release	release	NN
cord-015021-pol2qm74	6778	18	is	be	VBZ
cord-015021-pol2qm74	6778	19	associated	associate	VBN
cord-015021-pol2qm74	6778	20	with	with	IN
cord-015021-pol2qm74	6778	21	an	an	DT
cord-015021-pol2qm74	6778	22	enhancement	enhancement	NN
cord-015021-pol2qm74	6778	23	in	in	IN
cord-015021-pol2qm74	6778	24	pyrurate	pyrurate	NNP
cord-015021-pol2qm74	6778	25	release	release	NN
cord-015021-pol2qm74	6778	26	and	and	CC
cord-015021-pol2qm74	6778	27	with	with	IN
cord-015021-pol2qm74	6778	28	increase	increase	NN
cord-015021-pol2qm74	6778	29	levels	level	NNS
cord-015021-pol2qm74	6778	30	of	of	IN
cord-015021-pol2qm74	6778	31	cytosolic	cytosolic	JJ
cord-015021-pol2qm74	6778	32	free	free	JJ
cord-015021-pol2qm74	6778	33	NAD+/NADH	NAD+/NADH	NNP
cord-015021-pol2qm74	6778	34	ratio	ratio	NN
cord-015021-pol2qm74	6778	35	,	,	,
cord-015021-pol2qm74	6778	36	although	although	IN
cord-015021-pol2qm74	6778	37	it	-PRON-	PRP
cord-015021-pol2qm74	6778	38	is	be	VBZ
cord-015021-pol2qm74	6778	39	not	not	RB
cord-015021-pol2qm74	6778	40	evident	evident	JJ
cord-015021-pol2qm74	6778	41	~	~	NFP
cord-015021-pol2qm74	6778	42	ischemic	ischemic	JJ
cord-015021-pol2qm74	6778	43	group	group	NN
cord-015021-pol2qm74	6778	44	(	(	-LRB-
cord-015021-pol2qm74	6778	45	group	group	NN
cord-015021-pol2qm74	6778	46	Ba).It	Ba).It	NNP
cord-015021-pol2qm74	6778	47	is	be	VBZ
cord-015021-pol2qm74	6778	48	concluded	conclude	VBN
cord-015021-pol2qm74	6778	49	that	that	IN
cord-015021-pol2qm74	6778	50	the	the	DT
cord-015021-pol2qm74	6778	51	conversion	conversion	NN
cord-015021-pol2qm74	6778	52	of	of	IN
cord-015021-pol2qm74	6778	53	XD	XD	NNP
cord-015021-pol2qm74	6778	54	to	to	IN
cord-015021-pol2qm74	6778	55	XO	XO	NNP
cord-015021-pol2qm74	6778	56	is	be	VBZ
cord-015021-pol2qm74	6778	57	calcium	calcium	NN
cord-015021-pol2qm74	6778	58	independent	independent	JJ
cord-015021-pol2qm74	6778	59	.	.	.
cord-015021-pol2qm74	6779	1	Eicosanoids	Eicosanoids	NNP
cord-015021-pol2qm74	6779	2	like	like	IN
cord-015021-pol2qm74	6779	3	thromboxane	thromboxane	NN
cord-015021-pol2qm74	6779	4	A2	A2	NNP
cord-015021-pol2qm74	6779	5	,	,	,
cord-015021-pol2qm74	6779	6	leukotriene	leukotriene	NN
cord-015021-pol2qm74	6779	7	B4	B4	NNP
cord-015021-pol2qm74	6779	8	and	and	CC
cord-015021-pol2qm74	6779	9	leukotriene	leukotriene	NN
cord-015021-pol2qm74	6779	10	C4	C4	NNP
cord-015021-pol2qm74	6779	11	are	be	VBP
cord-015021-pol2qm74	6779	12	known	know	VBN
cord-015021-pol2qm74	6779	13	as	as	IN
cord-015021-pol2qm74	6779	14	promoters	promoter	NNS
cord-015021-pol2qm74	6779	15	of	of	IN
cord-015021-pol2qm74	6779	16	initial	initial	JJ
cord-015021-pol2qm74	6779	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6779	18	reactions	reaction	NNS
cord-015021-pol2qm74	6779	19	.	.	.
cord-015021-pol2qm74	6780	1	We	-PRON-	PRP
cord-015021-pol2qm74	6780	2	investigated	investigate	VBD
cord-015021-pol2qm74	6780	3	whether	whether	IN
cord-015021-pol2qm74	6780	4	oxygen	oxygen	NN
cord-015021-pol2qm74	6780	5	radicals	radical	NNS
cord-015021-pol2qm74	6780	6	(	(	-LRB-
cord-015021-pol2qm74	6780	7	OR	or	CC
cord-015021-pol2qm74	6780	8	)	)	-RRB-
cord-015021-pol2qm74	6780	9	are	be	VBP
cord-015021-pol2qm74	6780	10	able	able	JJ
cord-015021-pol2qm74	6780	11	to	to	TO
cord-015021-pol2qm74	6780	12	induce	induce	VB
cord-015021-pol2qm74	6780	13	a	a	DT
cord-015021-pol2qm74	6780	14	release	release	NN
cord-015021-pol2qm74	6780	15	of	of	IN
cord-015021-pol2qm74	6780	16	these	these	DT
cord-015021-pol2qm74	6780	17	eicosanoids	eicosanoid	NNS
cord-015021-pol2qm74	6780	18	in	in	IN
cord-015021-pol2qm74	6780	19	whole	whole	JJ
cord-015021-pol2qm74	6780	20	blood	blood	NN
cord-015021-pol2qm74	6780	21	.	.	.
cord-015021-pol2qm74	6781	1	Blood	blood	NN
cord-015021-pol2qm74	6781	2	from	from	IN
cord-015021-pol2qm74	6781	3	healthy	healthy	JJ
cord-015021-pol2qm74	6781	4	volunteers	volunteer	NNS
cord-015021-pol2qm74	6781	5	was	be	VBD
cord-015021-pol2qm74	6781	6	incubated	incubate	VBN
cord-015021-pol2qm74	6781	7	with	with	IN
cord-015021-pol2qm74	6781	8	xanthine	xanthine	NN
cord-015021-pol2qm74	6781	9	oxidase	oxidase	NN
cord-015021-pol2qm74	6781	10	/	/	SYM
cord-015021-pol2qm74	6781	11	hypoxanthine	hypoxanthine	NN
cord-015021-pol2qm74	6781	12	to	to	TO
cord-015021-pol2qm74	6781	13	generate	generate	VB
cord-015021-pol2qm74	6781	14	oxygen	oxygen	NN
cord-015021-pol2qm74	6781	15	radicals	radical	NNS
cord-015021-pol2qm74	6781	16	.	.	.
cord-015021-pol2qm74	6782	1	After	after	IN
cord-015021-pol2qm74	6782	2	0,5,15,30	0,5,15,30	CD
cord-015021-pol2qm74	6782	3	and	and	CC
cord-015021-pol2qm74	6782	4	60	60	CD
cord-015021-pol2qm74	6782	5	minutes	minute	NNS
cord-015021-pol2qm74	6782	6	plasma	plasma	NN
cord-015021-pol2qm74	6782	7	levels	level	NNS
cord-015021-pol2qm74	6782	8	of	of	IN
cord-015021-pol2qm74	6782	9	thromboxane	thromboxane	NN
cord-015021-pol2qm74	6782	10	B2	b2	NN
cord-015021-pol2qm74	6782	11	(	(	-LRB-
cord-015021-pol2qm74	6782	12	TxB2	TxB2	NNP
cord-015021-pol2qm74	6782	13	)	)	-RRB-
cord-015021-pol2qm74	6782	14	,	,	,
cord-015021-pol2qm74	6782	15	leukotriene	leukotriene	NN
cord-015021-pol2qm74	6782	16	B4	B4	NNP
cord-015021-pol2qm74	6782	17	(	(	-LRB-
cord-015021-pol2qm74	6782	18	LTB4	LTB4	NNP
cord-015021-pol2qm74	6782	19	)	)	-RRB-
cord-015021-pol2qm74	6782	20	and	and	CC
cord-015021-pol2qm74	6782	21	leukotriene	leukotriene	NN
cord-015021-pol2qm74	6782	22	C4	c4	NN
cord-015021-pol2qm74	6782	23	(	(	-LRB-
cord-015021-pol2qm74	6782	24	LTC4	LTC4	NNP
cord-015021-pol2qm74	6782	25	)	)	-RRB-
cord-015021-pol2qm74	6782	26	were	be	VBD
cord-015021-pol2qm74	6782	27	determined	determine	VBN
cord-015021-pol2qm74	6782	28	via	via	IN
cord-015021-pol2qm74	6782	29	ELISA	ELISA	NNP
cord-015021-pol2qm74	6782	30	technique	technique	NN
cord-015021-pol2qm74	6782	31	.	.	.
cord-015021-pol2qm74	6783	1	Another	another	DT
cord-015021-pol2qm74	6783	2	volunteer	volunteer	NN
cord-015021-pol2qm74	6783	3	had	have	VBD
cord-015021-pol2qm74	6783	4	taken	take	VBN
cord-015021-pol2qm74	6783	5	1000	1000	CD
cord-015021-pol2qm74	6783	6	mg	mg	NNP
cord-015021-pol2qm74	6783	7	Aspirin	Aspirin	NNP
cord-015021-pol2qm74	6783	8	one	one	CD
cord-015021-pol2qm74	6783	9	day	day	NN
cord-015021-pol2qm74	6783	10	before	before	IN
cord-015021-pol2qm74	6783	11	taking	take	VBG
cord-015021-pol2qm74	6783	12	the	the	DT
cord-015021-pol2qm74	6783	13	blood	blood	NN
cord-015021-pol2qm74	6783	14	sample	sample	NN
cord-015021-pol2qm74	6783	15	(	(	-LRB-
cord-015021-pol2qm74	6783	16	no7	no7	NNP
cord-015021-pol2qm74	6783	17	)	)	-RRB-
cord-015021-pol2qm74	6783	18	.	.	.
cord-015021-pol2qm74	6784	1	Results	result	NNS
cord-015021-pol2qm74	6784	2	:	:	:
cord-015021-pol2qm74	6785	1	TxB2	txb2	JJ
cord-015021-pol2qm74	6785	2	plasma	plasma	NN
cord-015021-pol2qm74	6785	3	levels	level	NNS
cord-015021-pol2qm74	6785	4	increased	increase	VBD
cord-015021-pol2qm74	6785	5	from	from	IN
cord-015021-pol2qm74	6785	6	14pg	14pg	NN
cord-015021-pol2qm74	6785	7	/	/	SYM
cord-015021-pol2qm74	6785	8	ml	ml	XX
cord-015021-pol2qm74	6785	9	at	at	IN
cord-015021-pol2qm74	6785	10	0min	0min	CD
cord-015021-pol2qm74	6785	11	to	to	IN
cord-015021-pol2qm74	6786	1	144pg	144pg	NNP
cord-015021-pol2qm74	6786	2	/	/	SYM
cord-015021-pol2qm74	6786	3	ml	ml	NN
cord-015021-pol2qm74	6786	4	,	,	,
cord-015021-pol2qm74	6786	5	350pg	350pg	NNP
cord-015021-pol2qm74	6786	6	/	/	SYM
cord-015021-pol2qm74	6786	7	ml	ml	XX
cord-015021-pol2qm74	6786	8	,	,	,
cord-015021-pol2qm74	6786	9	370pg	370pg	NNP
cord-015021-pol2qm74	6786	10	/	/	SYM
cord-015021-pol2qm74	6786	11	ml	ml	NN
cord-015021-pol2qm74	6786	12	and	and	CC
cord-015021-pol2qm74	6786	13	660pg	660pg	NNP
cord-015021-pol2qm74	6786	14	/	/	SYM
cord-015021-pol2qm74	6786	15	ml	ml	XX
cord-015021-pol2qm74	6786	16	at	at	IN
cord-015021-pol2qm74	6786	17	5,15,30	5,15,30	CD
cord-015021-pol2qm74	6786	18	and	and	CC
cord-015021-pol2qm74	6786	19	60min	60min	NN
cord-015021-pol2qm74	6786	20	(	(	-LRB-
cord-015021-pol2qm74	6786	21	p<0,01	p<0,01	NN
cord-015021-pol2qm74	6786	22	)	)	-RRB-
cord-015021-pol2qm74	6786	23	.	.	.
cord-015021-pol2qm74	6787	1	LTB4	LTB4	NNP
cord-015021-pol2qm74	6787	2	and	and	CC
cord-015021-pol2qm74	6787	3	LTC4	LTC4	NNP
cord-015021-pol2qm74	6787	4	plasma	plasma	NN
cord-015021-pol2qm74	6787	5	levels	level	NNS
cord-015021-pol2qm74	6787	6	showed	show	VBD
cord-015021-pol2qm74	6787	7	an	an	DT
cord-015021-pol2qm74	6787	8	increase	increase	NN
cord-015021-pol2qm74	6787	9	during	during	IN
cord-015021-pol2qm74	6787	10	the	the	DT
cord-015021-pol2qm74	6787	11	first	first	JJ
cord-015021-pol2qm74	6787	12	few	few	JJ
cord-015021-pol2qm74	6787	13	minutes	minute	NNS
cord-015021-pol2qm74	6787	14	(	(	-LRB-
cord-015021-pol2qm74	6787	15	LTB4	ltb4	NN
cord-015021-pol2qm74	6787	16	:	:	:
cord-015021-pol2qm74	6787	17	0min	0min	CD
cord-015021-pol2qm74	6787	18	:	:	:
cord-015021-pol2qm74	6787	19	llpg	llpg	CC
cord-015021-pol2qm74	6787	20	/	/	SYM
cord-015021-pol2qm74	6787	21	ml,5min	ml,5min	NNS
cord-015021-pol2qm74	6787	22	:	:	:
cord-015021-pol2qm74	6787	23	87pg	87pg	NN
cord-015021-pol2qm74	6787	24	/	/	SYM
cord-015021-pol2qm74	6787	25	ml	ml	NN
cord-015021-pol2qm74	6787	26	;	;	:
cord-015021-pol2qm74	6787	27	LTC4	LTC4	NNP
cord-015021-pol2qm74	6787	28	:	:	:
cord-015021-pol2qm74	6787	29	0min	0min	CD
cord-015021-pol2qm74	6787	30	:	:	:
cord-015021-pol2qm74	6788	1	23pg	23pg	NNP
cord-015021-pol2qm74	6788	2	/	/	SYM
cord-015021-pol2qm74	6788	3	ml	ml	XX
cord-015021-pol2qm74	6788	4	,	,	,
cord-015021-pol2qm74	6788	5	5min	5min	CD
cord-015021-pol2qm74	6788	6	:	:	:
cord-015021-pol2qm74	6789	1	97pg	97pg	NNP
cord-015021-pol2qm74	6789	2	/	/	SYM
cord-015021-pol2qm74	6789	3	ml	ml	NN
cord-015021-pol2qm74	6789	4	(	(	-LRB-
cord-015021-pol2qm74	6789	5	p<0,05	p<0,05	NNP
cord-015021-pol2qm74	6789	6	)	)	-RRB-
cord-015021-pol2qm74	6789	7	)	)	-RRB-
cord-015021-pol2qm74	6789	8	followed	follow	VBN
cord-015021-pol2qm74	6789	9	by	by	IN
cord-015021-pol2qm74	6789	10	a	a	DT
cord-015021-pol2qm74	6789	11	decrease	decrease	NN
cord-015021-pol2qm74	6789	12	to	to	IN
cord-015021-pol2qm74	6789	13	normal	normal	JJ
cord-015021-pol2qm74	6789	14	values	value	NNS
cord-015021-pol2qm74	6789	15	at	at	IN
cord-015021-pol2qm74	6789	16	15min	15min	NN
cord-015021-pol2qm74	6789	17	.	.	.
cord-015021-pol2qm74	6790	1	In	in	IN
cord-015021-pol2qm74	6790	2	the	the	DT
cord-015021-pol2qm74	6790	3	sample	sample	NN
cord-015021-pol2qm74	6790	4	no7	no7	NNP
cord-015021-pol2qm74	6790	5	the	the	DT
cord-015021-pol2qm74	6790	6	cyclooxigenase	cyclooxigenase	NN
cord-015021-pol2qm74	6790	7	-	-	HYPH
cord-015021-pol2qm74	6790	8	pathway	pathway	NN
cord-015021-pol2qm74	6790	9	was	be	VBD
cord-015021-pol2qm74	6790	10	completely	completely	RB
cord-015021-pol2qm74	6790	11	inhibited	inhibit	VBN
cord-015021-pol2qm74	6790	12	,	,	,
cord-015021-pol2qm74	6790	13	the	the	DT
cord-015021-pol2qm74	6790	14	TxB2	txb2	JJ
cord-015021-pol2qm74	6790	15	plasma	plasma	NN
cord-015021-pol2qm74	6790	16	-	-	HYPH
cord-015021-pol2qm74	6790	17	levels	level	NNS
cord-015021-pol2qm74	6790	18	did	do	VBD
cord-015021-pol2qm74	6790	19	not	not	RB
cord-015021-pol2qm74	6790	20	alter	alter	VB
cord-015021-pol2qm74	6790	21	at	at	RB
cord-015021-pol2qm74	6790	22	all	all	RB
cord-015021-pol2qm74	6790	23	,	,	,
cord-015021-pol2qm74	6790	24	whereas	whereas	IN
cord-015021-pol2qm74	6790	25	LTB4	LTB4	NNP
cord-015021-pol2qm74	6790	26	and	and	CC
cord-015021-pol2qm74	6790	27	LTC4-plasma	LTC4-plasma	NNP
cord-015021-pol2qm74	6790	28	levels	level	NNS
cord-015021-pol2qm74	6790	29	were	be	VBD
cord-015021-pol2qm74	6790	30	n't	not	RB
cord-015021-pol2qm74	6790	31	affected	affect	VBN
cord-015021-pol2qm74	6790	32	.	.	.
cord-015021-pol2qm74	6790	33	 	 	_SP
cord-015021-pol2qm74	6791	1	OPALLOGENEIC	OPALLOGENEIC	NNP
cord-015021-pol2qm74	6791	2	BLOOD	blood	NN
cord-015021-pol2qm74	6791	3	TRANSFUSION	transfusion	NN
cord-015021-pol2qm74	6791	4	Jane	Jane	NNP
cord-015021-pol2qm74	6791	5	Shelby	Shelby	NNP
cord-015021-pol2qm74	6791	6	,	,	,
cord-015021-pol2qm74	6791	7	Ph.D.	ph.d.	NN
cord-015021-pol2qm74	6791	8	,	,	,
cord-015021-pol2qm74	6791	9	and	and	CC
cord-015021-pol2qm74	6791	10	Edward	Edward	NNP
cord-015021-pol2qm74	6791	11	W	W	NNP
cord-015021-pol2qm74	6791	12	,	,	,
cord-015021-pol2qm74	6791	13	Nelson	Nelson	NNP
cord-015021-pol2qm74	6791	14	,	,	,
cord-015021-pol2qm74	6791	15	M.D	M.D	NNP
cord-015021-pol2qm74	6791	16	,	,	,
cord-015021-pol2qm74	6791	17	There	there	EX
cord-015021-pol2qm74	6791	18	have	have	VBP
cord-015021-pol2qm74	6791	19	been	be	VBN
cord-015021-pol2qm74	6791	20	numerous	numerous	JJ
cord-015021-pol2qm74	6791	21	investigations	investigation	NNS
cord-015021-pol2qm74	6791	22	dudng	dudng	VB
cord-015021-pol2qm74	6791	23	the	the	DT
cord-015021-pol2qm74	6791	24	last	last	JJ
cord-015021-pol2qm74	6791	25	two	two	CD
cord-015021-pol2qm74	6791	26	decades	decade	NNS
cord-015021-pol2qm74	6791	27	examining	examine	VBG
cord-015021-pol2qm74	6791	28	the	the	DT
cord-015021-pol2qm74	6791	29	effect	effect	NN
cord-015021-pol2qm74	6791	30	of	of	IN
cord-015021-pol2qm74	6791	31	surgery	surgery	NN
cord-015021-pol2qm74	6791	32	,	,	,
cord-015021-pol2qm74	6791	33	anesthesia	anesthesia	NN
cord-015021-pol2qm74	6791	34	,	,	,
cord-015021-pol2qm74	6791	35	blood	blood	NN
cord-015021-pol2qm74	6791	36	loss	loss	NN
cord-015021-pol2qm74	6791	37	and	and	CC
cord-015021-pol2qm74	6791	38	transfusion	transfusion	NN
cord-015021-pol2qm74	6791	39	on	on	IN
cord-015021-pol2qm74	6791	40	vadous	vadous	JJ
cord-015021-pol2qm74	6791	41	immune	immune	JJ
cord-015021-pol2qm74	6791	42	parameters	parameter	NNS
cord-015021-pol2qm74	6791	43	in	in	IN
cord-015021-pol2qm74	6791	44	humans	human	NNS
cord-015021-pol2qm74	6791	45	and	and	CC
cord-015021-pol2qm74	6791	46	animal	animal	NN
cord-015021-pol2qm74	6791	47	models	model	NNS
cord-015021-pol2qm74	6791	48	.	.	.
cord-015021-pol2qm74	6792	1	There	there	EX
cord-015021-pol2qm74	6792	2	appears	appear	VBZ
cord-015021-pol2qm74	6792	3	to	to	TO
cord-015021-pol2qm74	6792	4	be	be	VB
cord-015021-pol2qm74	6792	5	concurrence	concurrence	NN
cord-015021-pol2qm74	6792	6	among	among	IN
cord-015021-pol2qm74	6792	7	several	several	JJ
cord-015021-pol2qm74	6792	8	well	well	RB
cord-015021-pol2qm74	6792	9	controlled	control	VBN
cord-015021-pol2qm74	6792	10	studies	study	NNS
cord-015021-pol2qm74	6792	11	that	that	IN
cord-015021-pol2qm74	6792	12	transfusion	transfusion	NN
cord-015021-pol2qm74	6792	13	of	of	IN
cord-015021-pol2qm74	6792	14	whole	whole	JJ
cord-015021-pol2qm74	6792	15	blood	blood	NN
cord-015021-pol2qm74	6792	16	(	(	-LRB-
cord-015021-pol2qm74	6792	17	containing	contain	VBG
cord-015021-pol2qm74	6792	18	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	6792	19	)	)	-RRB-
cord-015021-pol2qm74	6792	20	,	,	,
cord-015021-pol2qm74	6792	21	has	have	VBZ
cord-015021-pol2qm74	6792	22	regulatory	regulatory	JJ
cord-015021-pol2qm74	6792	23	effects	effect	NNS
cord-015021-pol2qm74	6792	24	on	on	IN
cord-015021-pol2qm74	6792	25	immune	immune	JJ
cord-015021-pol2qm74	6792	26	ceil	ceil	NN
cord-015021-pol2qm74	6792	27	function	function	NN
cord-015021-pol2qm74	6792	28	which	which	WDT
cord-015021-pol2qm74	6792	29	include	include	VBP
cord-015021-pol2qm74	6792	30	decreased	decrease	VBN
cord-015021-pol2qm74	6792	31	cell	cell	NN
cord-015021-pol2qm74	6792	32	mediated	mediate	VBD
cord-015021-pol2qm74	6792	33	immune	immune	JJ
cord-015021-pol2qm74	6792	34	response	response	NN
cord-015021-pol2qm74	6792	35	,	,	,
cord-015021-pol2qm74	6792	36	and	and	CC
cord-015021-pol2qm74	6792	37	inhibition	inhibition	NN
cord-015021-pol2qm74	6792	38	of	of	IN
cord-015021-pol2qm74	6792	39	IL-2	IL-2	NNP
cord-015021-pol2qm74	6792	40	secretion	secretion	NN
cord-015021-pol2qm74	6792	41	.	.	.
cord-015021-pol2qm74	6793	1	These	these	DT
cord-015021-pol2qm74	6793	2	effects	effect	NNS
cord-015021-pol2qm74	6793	3	occur	occur	VBP
cord-015021-pol2qm74	6793	4	following	follow	VBG
cord-015021-pol2qm74	6793	5	transfusion	transfusion	NN
cord-015021-pol2qm74	6793	6	alone	alone	RB
cord-015021-pol2qm74	6793	7	and	and	CC
cord-015021-pol2qm74	6793	8	in	in	IN
cord-015021-pol2qm74	6793	9	con.cart	con.cart	NNP
cord-015021-pol2qm74	6793	10	with	with	IN
cord-015021-pol2qm74	6793	11	the	the	DT
cord-015021-pol2qm74	6793	12	distinct	distinct	JJ
cord-015021-pol2qm74	6793	13	immune	immune	JJ
cord-015021-pol2qm74	6793	14	effects	effect	NNS
cord-015021-pol2qm74	6793	15	of	of	IN
cord-015021-pol2qm74	6793	16	surgery	surgery	NN
cord-015021-pol2qm74	6793	17	,	,	,
cord-015021-pol2qm74	6793	18	trauma	trauma	NN
cord-015021-pol2qm74	6793	19	and	and	CC
cord-015021-pol2qm74	6793	20	anesthesla	anesthesla	NN
cord-015021-pol2qm74	6793	21	,	,	,
cord-015021-pol2qm74	6793	22	The	the	DT
cord-015021-pol2qm74	6793	23	clinical	clinical	JJ
cord-015021-pol2qm74	6793	24	consequences	consequence	NNS
cord-015021-pol2qm74	6793	25	of	of	IN
cord-015021-pol2qm74	6793	26	this	this	DT
cord-015021-pol2qm74	6793	27	immune	immune	JJ
cord-015021-pol2qm74	6793	28	modulation	modulation	NN
cord-015021-pol2qm74	6793	29	by	by	IN
cord-015021-pol2qm74	6793	30	transfusion	transfusion	NN
cord-015021-pol2qm74	6793	31	include	include	VBP
cord-015021-pol2qm74	6793	32	decreased	decrease	VBD
cord-015021-pol2qm74	6793	33	allogeneic	allogeneic	IN
cord-015021-pol2qm74	6793	34	response	response	NN
cord-015021-pol2qm74	6793	35	to	to	IN
cord-015021-pol2qm74	6793	36	transplanted	transplanted	JJ
cord-015021-pol2qm74	6793	37	organs	organ	NNS
cord-015021-pol2qm74	6793	38	,	,	,
cord-015021-pol2qm74	6793	39	which	which	WDT
cord-015021-pol2qm74	6793	40	has	have	VBZ
cord-015021-pol2qm74	6793	41	been	be	VBN
cord-015021-pol2qm74	6793	42	exploited	exploit	VBN
cord-015021-pol2qm74	6793	43	clinicelly	clinicelly	RB
cord-015021-pol2qm74	6793	44	in	in	IN
cord-015021-pol2qm74	6793	45	renal	renal	JJ
cord-015021-pol2qm74	6793	46	transplant	transplant	NN
cord-015021-pol2qm74	6793	47	patients	patient	NNS
cord-015021-pol2qm74	6793	48	.	.	.
cord-015021-pol2qm74	6794	1	Additionally	additionally	RB
cord-015021-pol2qm74	6794	2	,	,	,
cord-015021-pol2qm74	6794	3	there	there	EX
cord-015021-pol2qm74	6794	4	is	be	VBZ
cord-015021-pol2qm74	6794	5	evidence	evidence	NN
cord-015021-pol2qm74	6794	6	for	for	IN
cord-015021-pol2qm74	6794	7	a	a	DT
cord-015021-pol2qm74	6794	8	strong	strong	JJ
cord-015021-pol2qm74	6794	9	association	association	NN
cord-015021-pol2qm74	6794	10	with	with	IN
cord-015021-pol2qm74	6794	11	increased	increase	VBN
cord-015021-pol2qm74	6794	12	risk	risk	NN
cord-015021-pol2qm74	6794	13	for	for	IN
cord-015021-pol2qm74	6794	14	infection	infection	NN
cord-015021-pol2qm74	6794	15	in	in	IN
cord-015021-pol2qm74	6794	16	transfused	transfuse	VBN
cord-015021-pol2qm74	6794	17	patients	patient	NNS
cord-015021-pol2qm74	6794	18	following	follow	VBG
cord-015021-pol2qm74	6794	19	surgical	surgical	JJ
cord-015021-pol2qm74	6794	20	procedures	procedure	NNS
cord-015021-pol2qm74	6794	21	.	.	.
cord-015021-pol2qm74	6795	1	AIIogeneio	AIIogeneio	NNS
cord-015021-pol2qm74	6795	2	blood	blood	NN
cord-015021-pol2qm74	6795	3	transfusions	transfusion	NNS
cord-015021-pol2qm74	6795	4	have	have	VBP
cord-015021-pol2qm74	6795	5	been	be	VBN
cord-015021-pol2qm74	6795	6	shown	show	VBN
cord-015021-pol2qm74	6795	7	to	to	TO
cord-015021-pol2qm74	6795	8	inhibit	inhibit	VB
cord-015021-pol2qm74	6795	9	cellular	cellular	JJ
cord-015021-pol2qm74	6795	10	anti.bacterial	anti.bacterial	JJ
cord-015021-pol2qm74	6795	11	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6795	12	,	,	,
cord-015021-pol2qm74	6795	13	causing	cause	VBG
cord-015021-pol2qm74	6795	14	increased	increase	VBN
cord-015021-pol2qm74	6795	15	susceptibility	susceptibility	NN
cord-015021-pol2qm74	6795	16	to	to	IN
cord-015021-pol2qm74	6795	17	bacterial	bacterial	JJ
cord-015021-pol2qm74	6795	18	pathogens	pathogen	NNS
cord-015021-pol2qm74	6795	19	,	,	,
cord-015021-pol2qm74	6795	20	in	in	IN
cord-015021-pol2qm74	6795	21	humans	human	NNS
cord-015021-pol2qm74	6795	22	and	and	CC
cord-015021-pol2qm74	6795	23	in	in	IN
cord-015021-pol2qm74	6795	24	animal	animal	NN
cord-015021-pol2qm74	6795	25	models	model	NNS
cord-015021-pol2qm74	6795	26	.	.	.
cord-015021-pol2qm74	6796	1	There	there	EX
cord-015021-pol2qm74	6796	2	is	be	VBZ
cord-015021-pol2qm74	6796	3	also	also	RB
cord-015021-pol2qm74	6796	4	concern	concern	NN
cord-015021-pol2qm74	6796	5	that	that	IN
cord-015021-pol2qm74	6796	6	allog	allog	NN
cord-015021-pol2qm74	6796	7	~	~	CD
cord-015021-pol2qm74	6796	8	neiC	neiC	:
cord-015021-pol2qm74	6796	9	transfusion	transfusion	NN
cord-015021-pol2qm74	6796	10	may	may	MD
cord-015021-pol2qm74	6796	11	adversely	adversely	RB
cord-015021-pol2qm74	6796	12	affect	affect	VB
cord-015021-pol2qm74	6796	13	cancer	cancer	NN
cord-015021-pol2qm74	6796	14	patients	patient	NNS
cord-015021-pol2qm74	6796	15	,	,	,
cord-015021-pol2qm74	6796	16	resulting	result	VBG
cord-015021-pol2qm74	6796	17	in	in	IN
cord-015021-pol2qm74	6796	18	decreased	decreased	JJ
cord-015021-pol2qm74	6796	19	disease	disease	NN
cord-015021-pol2qm74	6796	20	-	-	HYPH
cord-015021-pol2qm74	6796	21	free	free	JJ
cord-015021-pol2qm74	6796	22	survival	survival	NN
cord-015021-pol2qm74	6796	23	.	.	.
cord-015021-pol2qm74	6797	1	Several	several	JJ
cord-015021-pol2qm74	6797	2	stategies	stategie	NNS
cord-015021-pol2qm74	6797	3	have	have	VBP
cord-015021-pol2qm74	6797	4	been	be	VBN
cord-015021-pol2qm74	6797	5	proposed	propose	VBN
cord-015021-pol2qm74	6797	6	to	to	TO
cord-015021-pol2qm74	6797	7	minimize	minimize	VB
cord-015021-pol2qm74	6797	8	the	the	DT
cord-015021-pol2qm74	6797	9	adverse	adverse	JJ
cord-015021-pol2qm74	6797	10	effects	effect	NNS
cord-015021-pol2qm74	6797	11	of	of	IN
cord-015021-pol2qm74	6797	12	blood	blood	NN
cord-015021-pol2qm74	6797	13	transfusion	transfusion	NN
cord-015021-pol2qm74	6797	14	.	.	.
cord-015021-pol2qm74	6798	1	There	there	EX
cord-015021-pol2qm74	6798	2	is	be	VBZ
cord-015021-pol2qm74	6798	3	evidence	evidence	NN
cord-015021-pol2qm74	6798	4	that	that	IN
cord-015021-pol2qm74	6798	5	the	the	DT
cord-015021-pol2qm74	6798	6	risk	risk	NN
cord-015021-pol2qm74	6798	7	of	of	IN
cord-015021-pol2qm74	6798	8	immune	immune	JJ
cord-015021-pol2qm74	6798	9	mediated	mediate	VBN
cord-015021-pol2qm74	6798	10	infectious	infectious	JJ
cord-015021-pol2qm74	6798	11	complications	complication	NNS
cord-015021-pol2qm74	6798	12	associated	associate	VBN
cord-015021-pol2qm74	6798	13	with	with	IN
cord-015021-pol2qm74	6798	14	transfusion	transfusion	NN
cord-015021-pol2qm74	6798	15	may	may	MD
cord-015021-pol2qm74	6798	16	be	be	VB
cord-015021-pol2qm74	6798	17	greatly	greatly	RB
cord-015021-pol2qm74	6798	18	minimized	minimize	VBN
cord-015021-pol2qm74	6798	19	wlth	wlth	IN
cord-015021-pol2qm74	6798	20	the	the	DT
cord-015021-pol2qm74	6798	21	use	use	NN
cord-015021-pol2qm74	6798	22	of	of	IN
cord-015021-pol2qm74	6798	23	autologous	autologous	JJ
cord-015021-pol2qm74	6798	24	blood	blood	NN
cord-015021-pol2qm74	6798	25	and	and	CC
cord-015021-pol2qm74	6798	26	leukocyte	leukocyte	NN
cord-015021-pol2qm74	6798	27	free	free	JJ
cord-015021-pol2qm74	6798	28	allogeneic	allogeneic	NN
cord-015021-pol2qm74	6798	29	blood.products	blood.product	NNS
cord-015021-pol2qm74	6798	30	in	in	IN
cord-015021-pol2qm74	6798	31	surgical	surgical	JJ
cord-015021-pol2qm74	6798	32	and	and	CC
cord-015021-pol2qm74	6798	33	trauma	trauma	NN
cord-015021-pol2qm74	6798	34	patients	patient	NNS
cord-015021-pol2qm74	6798	35	,	,	,
cord-015021-pol2qm74	6798	36	it	-PRON-	PRP
cord-015021-pol2qm74	6798	37	also	also	RB
cord-015021-pol2qm74	6798	38	appears	appear	VBZ
cord-015021-pol2qm74	6798	39	that	that	IN
cord-015021-pol2qm74	6798	40	the	the	DT
cord-015021-pol2qm74	6798	41	inhibition	inhibition	NN
cord-015021-pol2qm74	6798	42	of	of	IN
cord-015021-pol2qm74	6798	43	cellular	cellular	JJ
cord-015021-pol2qm74	6798	44	immune	immune	JJ
cord-015021-pol2qm74	6798	45	response	response	NN
cord-015021-pol2qm74	6798	46	and	and	CC
cord-015021-pol2qm74	6798	47	IL-2	il-2	NN
cord-015021-pol2qm74	6798	48	productiorl	productiorl	VBZ
cord-015021-pol2qm74	6798	49	following	follow	VBG
cord-015021-pol2qm74	6798	50	atlogeneic	atlogeneic	NNS
cord-015021-pol2qm74	6798	51	blood	blood	NN
cord-015021-pol2qm74	6798	52	transfusion	transfusion	NN
cord-015021-pol2qm74	6798	53	may	may	MD
cord-015021-pol2qm74	6798	54	be	be	VB
cord-015021-pol2qm74	6798	55	mediated	mediate	VBN
cord-015021-pol2qm74	6798	56	by	by	IN
cord-015021-pol2qm74	6798	57	increased	increase	VBN
cord-015021-pol2qm74	6798	58	prostaglandin	prostaglandin	NN
cord-015021-pol2qm74	6798	59	E2	E2	NNP
cord-015021-pol2qm74	6798	60	secretion	secretion	NN
cord-015021-pol2qm74	6798	61	,	,	,
cord-015021-pol2qm74	6798	62	and	and	CC
cord-015021-pol2qm74	6798	63	that	that	IN
cord-015021-pol2qm74	6798	64	immune	immune	JJ
cord-015021-pol2qm74	6798	65	response	response	NN
cord-015021-pol2qm74	6798	66	may	may	MD
cord-015021-pol2qm74	6798	67	be	be	VB
cord-015021-pol2qm74	6798	68	preserved	preserve	VBN
cord-015021-pol2qm74	6798	69	in	in	IN
cord-015021-pol2qm74	6798	70	allogeneio	allogeneio	NNS
cord-015021-pol2qm74	6798	71	whole	whole	JJ
cord-015021-pol2qm74	6798	72	blood	blood	NN
cord-015021-pol2qm74	6798	73	transfused	transfuse	VBN
cord-015021-pol2qm74	6798	74	subjects	subject	NNS
cord-015021-pol2qm74	6798	75	receiving	receive	VBG
cord-015021-pol2qm74	6798	76	c3Lc	c3lc	XX
cord-015021-pol2qm74	6798	77	~	~	CD
cord-015021-pol2qm74	6798	78	oxygenase	oxygenase	NN
cord-015021-pol2qm74	6798	79	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	6798	80	such	such	JJ
cord-015021-pol2qm74	6798	81	as	as	IN
cord-015021-pol2qm74	6798	82	ibuprofen	ibuprofen	NN
cord-015021-pol2qm74	6798	83	.	.	.
cord-015021-pol2qm74	6799	1	Among	among	IN
cord-015021-pol2qm74	6799	2	these	these	DT
cord-015021-pol2qm74	6799	3	are	be	VBP
cord-015021-pol2qm74	6799	4	various	various	JJ
cord-015021-pol2qm74	6799	5	alterations	alteration	NNS
cord-015021-pol2qm74	6799	6	in	in	IN
cord-015021-pol2qm74	6799	7	immune	immune	JJ
cord-015021-pol2qm74	6799	8	function	function	NN
cord-015021-pol2qm74	6799	9	.	.	.
cord-015021-pol2qm74	6800	1	Efforts	effort	NNS
cord-015021-pol2qm74	6800	2	have	have	VBP
cord-015021-pol2qm74	6800	3	therefore	therefore	RB
cord-015021-pol2qm74	6800	4	been	be	VBN
cord-015021-pol2qm74	6800	5	made	make	VBN
cord-015021-pol2qm74	6800	6	to	to	TO
cord-015021-pol2qm74	6800	7	utilize	utilize	VB
cord-015021-pol2qm74	6800	8	alternatives	alternative	NNS
cord-015021-pol2qm74	6800	9	to	to	IN
cord-015021-pol2qm74	6800	10	homologous	homologous	JJ
cord-015021-pol2qm74	6800	11	transfusions	transfusion	NNS
cord-015021-pol2qm74	6800	12	.	.	.
cord-015021-pol2qm74	6801	1	These	these	DT
cord-015021-pol2qm74	6801	2	include	include	VBP
cord-015021-pol2qm74	6801	3	the	the	DT
cord-015021-pol2qm74	6801	4	use	use	NN
cord-015021-pol2qm74	6801	5	of	of	IN
cord-015021-pol2qm74	6801	6	autologous	autologous	JJ
cord-015021-pol2qm74	6801	7	predonation	predonation	NN
cord-015021-pol2qm74	6801	8	,	,	,
cord-015021-pol2qm74	6801	9	supplemental	supplemental	JJ
cord-015021-pol2qm74	6801	10	iron	iron	NN
cord-015021-pol2qm74	6801	11	therapy	therapy	NN
cord-015021-pol2qm74	6801	12	,	,	,
cord-015021-pol2qm74	6801	13	and	and	CC
cord-015021-pol2qm74	6801	14	recombinant	recombinant	JJ
cord-015021-pol2qm74	6801	15	human	human	JJ
cord-015021-pol2qm74	6801	16	erythropoietin	erythropoietin	NN
cord-015021-pol2qm74	6801	17	.	.	.
cord-015021-pol2qm74	6802	1	Although	although	IN
cord-015021-pol2qm74	6802	2	initially	initially	RB
cord-015021-pol2qm74	6802	3	considered	consider	VBN
cord-015021-pol2qm74	6802	4	innocuous	innocuous	JJ
cord-015021-pol2qm74	6802	5	,	,	,
cord-015021-pol2qm74	6802	6	these	these	DT
cord-015021-pol2qm74	6802	7	therapies	therapy	NNS
cord-015021-pol2qm74	6802	8	are	be	VBP
cord-015021-pol2qm74	6802	9	now	now	RB
cord-015021-pol2qm74	6802	10	recognized	recognize	VBN
cord-015021-pol2qm74	6802	11	to	to	TO
cord-015021-pol2qm74	6802	12	have	have	VB
cord-015021-pol2qm74	6802	13	potential	potential	JJ
cord-015021-pol2qm74	6802	14	deliterious	deliterious	JJ
cord-015021-pol2qm74	6802	15	immune	immune	JJ
cord-015021-pol2qm74	6802	16	sequelae	sequela	NNS
cord-015021-pol2qm74	6802	17	.	.	.
cord-015021-pol2qm74	6803	1	Erythropoietin	erythropoietin	NN
cord-015021-pol2qm74	6803	2	,	,	,
cord-015021-pol2qm74	6803	3	by	by	IN
cord-015021-pol2qm74	6803	4	its	-PRON-	PRP$
cord-015021-pol2qm74	6803	5	ability	ability	NN
cord-015021-pol2qm74	6803	6	to	to	TO
cord-015021-pol2qm74	6803	7	lower	lower	VB
cord-015021-pol2qm74	6803	8	serum	serum	NN
cord-015021-pol2qm74	6803	9	iron	iron	NN
cord-015021-pol2qm74	6803	10	levels	level	NNS
cord-015021-pol2qm74	6803	11	,	,	,
cord-015021-pol2qm74	6803	12	can	can	MD
cord-015021-pol2qm74	6803	13	impair	impair	VB
cord-015021-pol2qm74	6803	14	both	both	DT
cord-015021-pol2qm74	6803	15	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	6803	16	and	and	CC
cord-015021-pol2qm74	6803	17	NK	NK	NNP
cord-015021-pol2qm74	6803	18	cell	cell	NN
cord-015021-pol2qm74	6803	19	activity	activity	NN
cord-015021-pol2qm74	6803	20	.	.	.
cord-015021-pol2qm74	6804	1	Autologous	autologous	JJ
cord-015021-pol2qm74	6804	2	donation	donation	NN
cord-015021-pol2qm74	6804	3	impairs	impair	VBZ
cord-015021-pol2qm74	6804	4	NK	NK	NNP
cord-015021-pol2qm74	6804	5	cell	cell	NN
cord-015021-pol2qm74	6804	6	function	function	NN
cord-015021-pol2qm74	6804	7	.	.	.
cord-015021-pol2qm74	6805	1	Finally	finally	RB
cord-015021-pol2qm74	6805	2	,	,	,
cord-015021-pol2qm74	6805	3	supplemental	supplemental	JJ
cord-015021-pol2qm74	6805	4	iron	iron	NN
cord-015021-pol2qm74	6805	5	therapy	therapy	NN
cord-015021-pol2qm74	6805	6	can	can	MD
cord-015021-pol2qm74	6805	7	stimulate	stimulate	VB
cord-015021-pol2qm74	6805	8	bacterial	bacterial	JJ
cord-015021-pol2qm74	6805	9	growth	growth	NN
cord-015021-pol2qm74	6805	10	and	and	CC
cord-015021-pol2qm74	6805	11	increase	increase	VB
cord-015021-pol2qm74	6805	12	the	the	DT
cord-015021-pol2qm74	6805	13	rate	rate	NN
cord-015021-pol2qm74	6805	14	of	of	IN
cord-015021-pol2qm74	6805	15	infectious	infectious	JJ
cord-015021-pol2qm74	6805	16	complications	complication	NNS
cord-015021-pol2qm74	6805	17	.	.	.
cord-015021-pol2qm74	6806	1	This	this	DT
cord-015021-pol2qm74	6806	2	talk	talk	NN
cord-015021-pol2qm74	6806	3	will	will	MD
cord-015021-pol2qm74	6806	4	present	present	VB
cord-015021-pol2qm74	6806	5	a	a	DT
cord-015021-pol2qm74	6806	6	discussion	discussion	NN
cord-015021-pol2qm74	6806	7	of	of	IN
cord-015021-pol2qm74	6806	8	these	these	DT
cord-015021-pol2qm74	6806	9	factors	factor	NNS
cord-015021-pol2qm74	6806	10	as	as	RB
cord-015021-pol2qm74	6806	11	well	well	RB
cord-015021-pol2qm74	6806	12	as	as	IN
cord-015021-pol2qm74	6806	13	a	a	DT
cord-015021-pol2qm74	6806	14	weighting	weighting	NN
cord-015021-pol2qm74	6806	15	of	of	IN
cord-015021-pol2qm74	6806	16	their	-PRON-	PRP$
cord-015021-pol2qm74	6806	17	importance	importance	NN
cord-015021-pol2qm74	6806	18	.	.	.
cord-015021-pol2qm74	6807	1	R.L	R.L	NNP
cord-015021-pol2qm74	6807	2	Rutan	Rutan	NNP
cord-015021-pol2qm74	6807	3	,	,	,
cord-015021-pol2qm74	6807	4	RN;BSN	RN;BSN	NNP
cord-015021-pol2qm74	6807	5	,	,	,
cord-015021-pol2qm74	6807	6	Shriners	Shriners	NNP
cord-015021-pol2qm74	6807	7	Burns	Burns	NNP
cord-015021-pol2qm74	6807	8	Institute	Institute	NNP
cord-015021-pol2qm74	6807	9	and	and	CC
cord-015021-pol2qm74	6807	10	The	the	DT
cord-015021-pol2qm74	6807	11	University	University	NNP
cord-015021-pol2qm74	6807	12	of	of	IN
cord-015021-pol2qm74	6807	13	Texas	Texas	NNP
cord-015021-pol2qm74	6807	14	Medical	Medical	NNP
cord-015021-pol2qm74	6807	15	Branch	Branch	NNP
cord-015021-pol2qm74	6807	16	,	,	,
cord-015021-pol2qm74	6807	17	Galveston	Galveston	NNP
cord-015021-pol2qm74	6807	18	TX	TX	NNP
cord-015021-pol2qm74	6807	19	,	,	,
cord-015021-pol2qm74	6807	20	USA	USA	NNP
cord-015021-pol2qm74	6808	1	The	the	DT
cord-015021-pol2qm74	6808	2	serious	serious	JJ
cord-015021-pol2qm74	6808	3	sequelae	sequela	NNS
cord-015021-pol2qm74	6808	4	of	of	IN
cord-015021-pol2qm74	6808	5	homologous	homologous	JJ
cord-015021-pol2qm74	6808	6	blood	blood	NN
cord-015021-pol2qm74	6808	7	transfusions	transfusion	NNS
cord-015021-pol2qm74	6808	8	have	have	VBP
cord-015021-pol2qm74	6808	9	resulted	result	VBN
cord-015021-pol2qm74	6808	10	in	in	IN
cord-015021-pol2qm74	6808	11	vigorous	vigorous	JJ
cord-015021-pol2qm74	6808	12	efforts	effort	NNS
cord-015021-pol2qm74	6808	13	at	at	IN
cord-015021-pol2qm74	6808	14	identifying	identify	VBG
cord-015021-pol2qm74	6808	15	alternate	alternate	JJ
cord-015021-pol2qm74	6808	16	therapies	therapy	NNS
cord-015021-pol2qm74	6808	17	for	for	IN
cord-015021-pol2qm74	6808	18	correcting	correct	VBG
cord-015021-pol2qm74	6808	19	red	red	JJ
cord-015021-pol2qm74	6808	20	blood	blood	NN
cord-015021-pol2qm74	6808	21	cell	cell	NN
cord-015021-pol2qm74	6808	22	(	(	-LRB-
cord-015021-pol2qm74	6808	23	RBC	RBC	NNP
cord-015021-pol2qm74	6808	24	)	)	-RRB-
cord-015021-pol2qm74	6808	25	deficits	deficit	NNS
cord-015021-pol2qm74	6808	26	.	.	.
cord-015021-pol2qm74	6809	1	Erythropoietin	Erythropoietin	NNP
cord-015021-pol2qm74	6809	2	(	(	-LRB-
cord-015021-pol2qm74	6809	3	EPO	EPO	NNP
cord-015021-pol2qm74	6809	4	)	)	-RRB-
cord-015021-pol2qm74	6809	5	was	be	VBD
cord-015021-pol2qm74	6809	6	hypothesized	hypothesize	VBN
cord-015021-pol2qm74	6809	7	to	to	TO
cord-015021-pol2qm74	6809	8	exist	exist	VB
cord-015021-pol2qm74	6809	9	in	in	IN
cord-015021-pol2qm74	6809	10	the	the	DT
cord-015021-pol2qm74	6809	11	early	early	JJ
cord-015021-pol2qm74	6809	12	20th	20th	JJ
cord-015021-pol2qm74	6809	13	century	century	NN
cord-015021-pol2qm74	6809	14	,	,	,
cord-015021-pol2qm74	6809	15	however	however	RB
cord-015021-pol2qm74	6809	16	the	the	DT
cord-015021-pol2qm74	6809	17	protein	protein	NN
cord-015021-pol2qm74	6809	18	was	be	VBD
cord-015021-pol2qm74	6809	19	not	not	RB
cord-015021-pol2qm74	6809	20	isolaled	isolale	VBN
cord-015021-pol2qm74	6809	21	until	until	IN
cord-015021-pol2qm74	6809	22	1977	1977	CD
cord-015021-pol2qm74	6809	23	.	.	.
cord-015021-pol2qm74	6810	1	The	the	DT
cord-015021-pol2qm74	6810	2	human	human	JJ
cord-015021-pol2qm74	6810	3	gene	gene	NN
cord-015021-pol2qm74	6810	4	was	be	VBD
cord-015021-pol2qm74	6810	5	identified	identify	VBN
cord-015021-pol2qm74	6810	6	and	and	CC
cord-015021-pol2qm74	6810	7	cloned	clone	VBN
cord-015021-pol2qm74	6810	8	in	in	IN
cord-015021-pol2qm74	6810	9	1983	1983	CD
cord-015021-pol2qm74	6810	10	,	,	,
cord-015021-pol2qm74	6810	11	which	which	WDT
cord-015021-pol2qm74	6810	12	permitted	permit	VBD
cord-015021-pol2qm74	6810	13	the	the	DT
cord-015021-pol2qm74	6810	14	production	production	NN
cord-015021-pol2qm74	6810	15	of	of	IN
cord-015021-pol2qm74	6810	16	EPO	EPO	NNP
cord-015021-pol2qm74	6810	17	through	through	IN
cord-015021-pol2qm74	6810	18	recombinant	recombinant	JJ
cord-015021-pol2qm74	6810	19	techniques	technique	NNS
cord-015021-pol2qm74	6810	20	.	.	.
cord-015021-pol2qm74	6811	1	The	the	DT
cord-015021-pol2qm74	6811	2	earliest	early	JJS
cord-015021-pol2qm74	6811	3	clinical	clinical	JJ
cord-015021-pol2qm74	6811	4	trials	trial	NNS
cord-015021-pol2qm74	6811	5	were	be	VBD
cord-015021-pol2qm74	6811	6	performed	perform	VBN
cord-015021-pol2qm74	6811	7	in	in	IN
cord-015021-pol2qm74	6811	8	anemic	anemic	JJ
cord-015021-pol2qm74	6811	9	end	end	JJ
cord-015021-pol2qm74	6811	10	-	-	HYPH
cord-015021-pol2qm74	6811	11	stage	stage	NN
cord-015021-pol2qm74	6811	12	renal	renal	JJ
cord-015021-pol2qm74	6811	13	failure	failure	NN
cord-015021-pol2qm74	6811	14	palients	palient	NNS
cord-015021-pol2qm74	6811	15	on	on	IN
cord-015021-pol2qm74	6811	16	hemodialysis	hemodialysis	NN
cord-015021-pol2qm74	6811	17	.	.	.
cord-015021-pol2qm74	6812	1	Treated	treat	VBN
cord-015021-pol2qm74	6812	2	patients	patient	NNS
cord-015021-pol2qm74	6812	3	experienced	experience	VBD
cord-015021-pol2qm74	6812	4	increases	increase	NNS
cord-015021-pol2qm74	6812	5	in	in	IN
cord-015021-pol2qm74	6812	6	erythropoiesis	erythropoiesis	NN
cord-015021-pol2qm74	6812	7	with	with	IN
cord-015021-pol2qm74	6812	8	normalization	normalization	NN
cord-015021-pol2qm74	6812	9	of	of	IN
cord-015021-pol2qm74	6812	10	hematocrit	hematocrit	NN
cord-015021-pol2qm74	6812	11	and	and	CC
cord-015021-pol2qm74	6812	12	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6812	13	levels	level	NNS
cord-015021-pol2qm74	6812	14	,	,	,
cord-015021-pol2qm74	6812	15	cessation	cessation	NN
cord-015021-pol2qm74	6812	16	of	of	IN
cord-015021-pol2qm74	6812	17	lrans	lran	NNS
cord-015021-pol2qm74	6812	18	-	-	HYPH
cord-015021-pol2qm74	6812	19	fusion	fusion	NN
cord-015021-pol2qm74	6812	20	requirements	requirement	NNS
cord-015021-pol2qm74	6812	21	and	and	CC
cord-015021-pol2qm74	6812	22	improvement	improvement	NN
cord-015021-pol2qm74	6812	23	in	in	IN
cord-015021-pol2qm74	6812	24	general	general	JJ
cord-015021-pol2qm74	6812	25	wellbeing	wellbeing	NN
cord-015021-pol2qm74	6812	26	.	.	.
cord-015021-pol2qm74	6813	1	These	these	DT
cord-015021-pol2qm74	6813	2	studies	study	NNS
cord-015021-pol2qm74	6813	3	,	,	,
cord-015021-pol2qm74	6813	4	however	however	RB
cord-015021-pol2qm74	6813	5	,	,	,
cord-015021-pol2qm74	6813	6	identified	identify	VBD
cord-015021-pol2qm74	6813	7	side	side	NN
cord-015021-pol2qm74	6813	8	effects	effect	NNS
cord-015021-pol2qm74	6813	9	of	of	IN
cord-015021-pol2qm74	6813	10	EPO	EPO	NNP
cord-015021-pol2qm74	6813	11	treatment	treatment	NN
cord-015021-pol2qm74	6813	12	such	such	JJ
cord-015021-pol2qm74	6813	13	as	as	IN
cord-015021-pol2qm74	6813	14	hypertension	hypertension	NN
cord-015021-pol2qm74	6813	15	,	,	,
cord-015021-pol2qm74	6813	16	seizures	seizure	NNS
cord-015021-pol2qm74	6813	17	and	and	CC
cord-015021-pol2qm74	6813	18	Ee	Ee	NNP
cord-015021-pol2qm74	6813	19	deficiency	deficiency	NN
cord-015021-pol2qm74	6813	20	.	.	.
cord-015021-pol2qm74	6814	1	Volunteer	volunteer	NN
cord-015021-pol2qm74	6814	2	trials	trial	NNS
cord-015021-pol2qm74	6814	3	have	have	VBP
cord-015021-pol2qm74	6814	4	established	establish	VBN
cord-015021-pol2qm74	6814	5	that	that	IN
cord-015021-pol2qm74	6814	6	the	the	DT
cord-015021-pol2qm74	6814	7	hypertension	hypertension	NN
cord-015021-pol2qm74	6814	8	is	be	VBZ
cord-015021-pol2qm74	6814	9	not	not	RB
cord-015021-pol2qm74	6814	10	a	a	DT
cord-015021-pol2qm74	6814	11	direct	direct	JJ
cord-015021-pol2qm74	6814	12	pressor	pressor	NN
cord-015021-pol2qm74	6814	13	effect	effect	NN
cord-015021-pol2qm74	6814	14	but	but	CC
cord-015021-pol2qm74	6814	15	rather	rather	RB
cord-015021-pol2qm74	6814	16	the	the	DT
cord-015021-pol2qm74	6814	17	result	result	NN
cord-015021-pol2qm74	6814	18	of	of	IN
cord-015021-pol2qm74	6814	19	abnormally	abnormally	RB
cord-015021-pol2qm74	6814	20	rapid	rapid	JJ
cord-015021-pol2qm74	6814	21	increases	increase	NNS
cord-015021-pol2qm74	6814	22	in	in	IN
cord-015021-pol2qm74	6814	23	red	red	JJ
cord-015021-pol2qm74	6814	24	cell	cell	NN
cord-015021-pol2qm74	6814	25	mass	mass	NN
cord-015021-pol2qm74	6814	26	in	in	IN
cord-015021-pol2qm74	6814	27	the	the	DT
cord-015021-pol2qm74	6814	28	face	face	NN
cord-015021-pol2qm74	6814	29	of	of	IN
cord-015021-pol2qm74	6814	30	the	the	DT
cord-015021-pol2qm74	6814	31	incompetent	incompetent	JJ
cord-015021-pol2qm74	6814	32	volume	volume	NN
cord-015021-pol2qm74	6814	33	-	-	HYPH
cord-015021-pol2qm74	6814	34	controlling	control	VBG
cord-015021-pol2qm74	6814	35	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6814	36	of	of	IN
cord-015021-pol2qm74	6814	37	the	the	DT
cord-015021-pol2qm74	6814	38	end	end	NN
cord-015021-pol2qm74	6814	39	stage	stage	NN
cord-015021-pol2qm74	6814	40	renal	renal	JJ
cord-015021-pol2qm74	6814	41	failure	failure	NN
cord-015021-pol2qm74	6814	42	patient	patient	NN
cord-015021-pol2qm74	6814	43	.	.	.
cord-015021-pol2qm74	6815	1	Lower	low	JJR
cord-015021-pol2qm74	6815	2	doses	dose	NNS
cord-015021-pol2qm74	6815	3	of	of	IN
cord-015021-pol2qm74	6815	4	EPO	EPO	NNP
cord-015021-pol2qm74	6815	5	and	and	CC
cord-015021-pol2qm74	6815	6	the	the	DT
cord-015021-pol2qm74	6815	7	subsequent	subsequent	JJ
cord-015021-pol2qm74	6815	8	gradual	gradual	JJ
cord-015021-pol2qm74	6815	9	increases	increase	NNS
cord-015021-pol2qm74	6815	10	in	in	IN
cord-015021-pol2qm74	6815	11	red	red	JJ
cord-015021-pol2qm74	6815	12	cell	cell	NN
cord-015021-pol2qm74	6815	13	mass	mass	NN
cord-015021-pol2qm74	6815	14	are	be	VBP
cord-015021-pol2qm74	6815	15	associated	associate	VBN
cord-015021-pol2qm74	6815	16	with	with	IN
cord-015021-pol2qm74	6815	17	significantly	significantly	RB
cord-015021-pol2qm74	6815	18	lower	low	JJR
cord-015021-pol2qm74	6815	19	incidences	incidence	NNS
cord-015021-pol2qm74	6815	20	of	of	IN
cord-015021-pol2qm74	6815	21	hypertensive	hypertensive	JJ
cord-015021-pol2qm74	6815	22	complications	complication	NNS
cord-015021-pol2qm74	6815	23	of	of	IN
cord-015021-pol2qm74	6815	24	EPO	EPO	NNP
cord-015021-pol2qm74	6815	25	therapy	therapy	NN
cord-015021-pol2qm74	6815	26	.	.	.
cord-015021-pol2qm74	6816	1	Likewise	likewise	RB
cord-015021-pol2qm74	6816	2	,	,	,
cord-015021-pol2qm74	6816	3	seizure	seizure	NN
cord-015021-pol2qm74	6816	4	activity	activity	NN
cord-015021-pol2qm74	6816	5	is	be	VBZ
cord-015021-pol2qm74	6816	6	not	not	RB
cord-015021-pol2qm74	6816	7	the	the	DT
cord-015021-pol2qm74	6816	8	result	result	NN
cord-015021-pol2qm74	6816	9	of	of	IN
cord-015021-pol2qm74	6816	10	a	a	DT
cord-015021-pol2qm74	6816	11	direct	direct	JJ
cord-015021-pol2qm74	6816	12	epileptogenie	epileptogenie	NN
cord-015021-pol2qm74	6816	13	effect	effect	NN
cord-015021-pol2qm74	6816	14	but	but	CC
cord-015021-pol2qm74	6816	15	parallels	parallel	VBZ
cord-015021-pol2qm74	6816	16	the	the	DT
cord-015021-pol2qm74	6816	17	incidence	incidence	NN
cord-015021-pol2qm74	6816	18	of	of	IN
cord-015021-pol2qm74	6816	19	hyper	hyper	JJ
cord-015021-pol2qm74	6816	20	-	-	JJ
cord-015021-pol2qm74	6816	21	tensive	tensive	JJ
cord-015021-pol2qm74	6816	22	-	-	HYPH
cord-015021-pol2qm74	6816	23	related	relate	VBN
cord-015021-pol2qm74	6816	24	sequelae	sequela	NNS
cord-015021-pol2qm74	6816	25	during	during	IN
cord-015021-pol2qm74	6816	26	high.dose	high.dose	NNP
cord-015021-pol2qm74	6816	27	EPO	EPO	NNP
cord-015021-pol2qm74	6816	28	treatment	treatment	NN
cord-015021-pol2qm74	6816	29	.	.	.
cord-015021-pol2qm74	6817	1	In	in	IN
cord-015021-pol2qm74	6817	2	cross	cross	JJ
cord-015021-pol2qm74	6817	3	-	-	HYPH
cord-015021-pol2qm74	6817	4	over	over	RP
cord-015021-pol2qm74	6817	5	designed	design	VBN
cord-015021-pol2qm74	6817	6	studies	study	NNS
cord-015021-pol2qm74	6817	7	,	,	,
cord-015021-pol2qm74	6817	8	pre	pre	VBN
cord-015021-pol2qm74	6817	9	-	-	JJ
cord-015021-pol2qm74	6817	10	existing	existing	JJ
cord-015021-pol2qm74	6817	11	iron	iron	NN
cord-015021-pol2qm74	6817	12	deficiency	deficiency	NN
cord-015021-pol2qm74	6817	13	has	have	VBZ
cord-015021-pol2qm74	6817	14	been	be	VBN
cord-015021-pol2qm74	6817	15	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	6817	16	to	to	TO
cord-015021-pol2qm74	6817	17	decrease	decrease	VB
cord-015021-pol2qm74	6817	18	or	or	CC
cord-015021-pol2qm74	6817	19	negate	negate	VB
cord-015021-pol2qm74	6817	20	stimulated	stimulate	VBN
cord-015021-pol2qm74	6817	21	erythropoiesis	erythropoiesis	NN
cord-015021-pol2qm74	6817	22	but	but	CC
cord-015021-pol2qm74	6817	23	effective	effective	JJ
cord-015021-pol2qm74	6817	24	-	-	:
cord-015021-pol2qm74	6817	25	hess	hess	NNP
cord-015021-pol2qm74	6817	26	can	can	MD
cord-015021-pol2qm74	6817	27	be	be	VB
cord-015021-pol2qm74	6817	28	restored	restore	VBN
cord-015021-pol2qm74	6817	29	with	with	IN
cord-015021-pol2qm74	6817	30	appropriate	appropriate	JJ
cord-015021-pol2qm74	6817	31	Fe	Fe	NNP
cord-015021-pol2qm74	6817	32	supplementation	supplementation	NN
cord-015021-pol2qm74	6817	33	.	.	.
cord-015021-pol2qm74	6818	1	Exogenous	exogenous	JJ
cord-015021-pol2qm74	6818	2	EPO	EPO	NNP
cord-015021-pol2qm74	6818	3	is	be	VBZ
cord-015021-pol2qm74	6818	4	effective	effective	JJ
cord-015021-pol2qm74	6818	5	whether	whether	IN
cord-015021-pol2qm74	6818	6	given	give	VBN
cord-015021-pol2qm74	6818	7	by	by	IN
cord-015021-pol2qm74	6818	8	IV	IV	NNP
cord-015021-pol2qm74	6818	9	or	or	CC
cord-015021-pol2qm74	6818	10	SQ	SQ	NNP
cord-015021-pol2qm74	6818	11	routes	route	NNS
cord-015021-pol2qm74	6818	12	and	and	CC
cord-015021-pol2qm74	6818	13	dose	dose	NN
cord-015021-pol2qm74	6818	14	response	response	NN
cord-015021-pol2qm74	6818	15	curves	curve	NNS
cord-015021-pol2qm74	6818	16	do	do	VBP
cord-015021-pol2qm74	6818	17	not	not	RB
cord-015021-pol2qm74	6818	18	vary	vary	VB
cord-015021-pol2qm74	6818	19	with	with	IN
cord-015021-pol2qm74	6818	20	route	route	NN
cord-015021-pol2qm74	6818	21	of	of	IN
cord-015021-pol2qm74	6818	22	administration	administration	NN
cord-015021-pol2qm74	6818	23	.	.	.
cord-015021-pol2qm74	6819	1	Increases	increase	NNS
cord-015021-pol2qm74	6819	2	in	in	IN
cord-015021-pol2qm74	6819	3	RBC	RBC	NNP
cord-015021-pol2qm74	6819	4	mass	mass	NN
cord-015021-pol2qm74	6819	5	are	be	VBP
cord-015021-pol2qm74	6819	6	directly	directly	RB
cord-015021-pol2qm74	6819	7	related	relate	VBN
cord-015021-pol2qm74	6819	8	to	to	IN
cord-015021-pol2qm74	6819	9	the	the	DT
cord-015021-pol2qm74	6819	10	dose	dose	NN
cord-015021-pol2qm74	6819	11	of	of	IN
cord-015021-pol2qm74	6819	12	EPO	EPO	NNP
cord-015021-pol2qm74	6819	13	,	,	,
cord-015021-pol2qm74	6819	14	both	both	CC
cord-015021-pol2qm74	6819	15	in	in	IN
cord-015021-pol2qm74	6819	16	amount	amount	NN
cord-015021-pol2qm74	6819	17	and	and	CC
cord-015021-pol2qm74	6819	18	frequency	frequency	NN
cord-015021-pol2qm74	6819	19	of	of	IN
cord-015021-pol2qm74	6819	20	administration	administration	NN
cord-015021-pol2qm74	6819	21	although	although	IN
cord-015021-pol2qm74	6819	22	there	there	EX
cord-015021-pol2qm74	6819	23	is	be	VBZ
cord-015021-pol2qm74	6819	24	a	a	DT
cord-015021-pol2qm74	6819	25	3	3	CD
cord-015021-pol2qm74	6819	26	-	-	SYM
cord-015021-pol2qm74	6819	27	5	5	CD
cord-015021-pol2qm74	6819	28	day	day	NN
cord-015021-pol2qm74	6819	29	time	time	NN
cord-015021-pol2qm74	6819	30	lag	lag	VB
cord-015021-pol2qm74	6819	31	between	between	IN
cord-015021-pol2qm74	6819	32	the	the	DT
cord-015021-pol2qm74	6819	33	first	first	JJ
cord-015021-pol2qm74	6819	34	EPO	EPO	NNP
cord-015021-pol2qm74	6819	35	dose	dose	NN
cord-015021-pol2qm74	6819	36	and	and	CC
cord-015021-pol2qm74	6819	37	laboratory	laboratory	NN
cord-015021-pol2qm74	6819	38	indications	indication	NNS
cord-015021-pol2qm74	6819	39	of	of	IN
cord-015021-pol2qm74	6819	40	its	-PRON-	PRP$
cord-015021-pol2qm74	6819	41	action	action	NN
cord-015021-pol2qm74	6819	42	(	(	-LRB-
cord-015021-pol2qm74	6819	43	i.e.	i.e.	FW
cord-015021-pol2qm74	6819	44	increase	increase	NN
cord-015021-pol2qm74	6819	45	in	in	IN
cord-015021-pol2qm74	6819	46	the	the	DT
cord-015021-pol2qm74	6819	47	number	number	NN
cord-015021-pol2qm74	6819	48	of	of	IN
cord-015021-pol2qm74	6819	49	reticulceytes	reticulceyte	NNS
cord-015021-pol2qm74	6819	50	in	in	IN
cord-015021-pol2qm74	6819	51	peripheral	peripheral	JJ
cord-015021-pol2qm74	6819	52	Wood	Wood	NNP
cord-015021-pol2qm74	6819	53	)	)	-RRB-
cord-015021-pol2qm74	6819	54	.	.	.
cord-015021-pol2qm74	6820	1	EPO	EPO	NNP
cord-015021-pol2qm74	6820	2	is	be	VBZ
cord-015021-pol2qm74	6820	3	currently	currently	RB
cord-015021-pol2qm74	6820	4	labelled	label	VBN
cord-015021-pol2qm74	6820	5	for	for	IN
cord-015021-pol2qm74	6820	6	use	use	NN
cord-015021-pol2qm74	6820	7	in	in	IN
cord-015021-pol2qm74	6820	8	the	the	DT
cord-015021-pol2qm74	6820	9	treatment	treatment	NN
cord-015021-pol2qm74	6820	10	of	of	IN
cord-015021-pol2qm74	6820	11	anemias	anemia	NNS
cord-015021-pol2qm74	6820	12	associated	associate	VBN
cord-015021-pol2qm74	6820	13	with	with	IN
cord-015021-pol2qm74	6820	14	end	end	NN
cord-015021-pol2qm74	6820	15	-	-	HYPH
cord-015021-pol2qm74	6820	16	stage	stage	NN
cord-015021-pol2qm74	6820	17	renal	renal	JJ
cord-015021-pol2qm74	6820	18	disease	disease	NN
cord-015021-pol2qm74	6820	19	and	and	CC
cord-015021-pol2qm74	6820	20	AIDS	AIDS	NNP
cord-015021-pol2qm74	6820	21	.	.	.
cord-015021-pol2qm74	6821	1	However	however	RB
cord-015021-pol2qm74	6821	2	,	,	,
cord-015021-pol2qm74	6821	3	its	-PRON-	PRP$
cord-015021-pol2qm74	6821	4	use	use	NN
cord-015021-pol2qm74	6821	5	in	in	IN
cord-015021-pol2qm74	6821	6	the	the	DT
cord-015021-pol2qm74	6821	7	surgical	surgical	JJ
cord-015021-pol2qm74	6821	8	population	population	NN
cord-015021-pol2qm74	6821	9	has	have	VBZ
cord-015021-pol2qm74	6821	10	been	be	VBN
cord-015021-pol2qm74	6821	11	explored	explore	VBN
cord-015021-pol2qm74	6821	12	because	because	IN
cord-015021-pol2qm74	6821	13	of	of	IN
cord-015021-pol2qm74	6821	14	its	-PRON-	PRP$
cord-015021-pol2qm74	6821	15	unique	unique	JJ
cord-015021-pol2qm74	6821	16	direct	direct	JJ
cord-015021-pol2qm74	6821	17	dose	dose	NN
cord-015021-pol2qm74	6821	18	-	-	HYPH
cord-015021-pol2qm74	6821	19	response	response	NN
cord-015021-pol2qm74	6821	20	,	,	,
cord-015021-pol2qm74	6821	21	EPO	EPO	NNP
cord-015021-pol2qm74	6821	22	has	have	VBZ
cord-015021-pol2qm74	6821	23	been	be	VBN
cord-015021-pol2qm74	6821	24	used	use	VBN
cord-015021-pol2qm74	6821	25	to	to	TO
cord-015021-pol2qm74	6821	26	effectively	effectively	RB
cord-015021-pol2qm74	6821	27	increase	increase	VB
cord-015021-pol2qm74	6821	28	the	the	DT
cord-015021-pol2qm74	6821	29	blood	blood	NN
cord-015021-pol2qm74	6821	30	harvest	harvest	NN
cord-015021-pol2qm74	6821	31	amounls	amounls	NN
cord-015021-pol2qm74	6821	32	in	in	IN
cord-015021-pol2qm74	6821	33	autologous	autologous	JJ
cord-015021-pol2qm74	6821	34	pre	pre	JJ
cord-015021-pol2qm74	6821	35	-	-	NN
cord-015021-pol2qm74	6821	36	donation	donation	NN
cord-015021-pol2qm74	6821	37	,	,	,
cord-015021-pol2qm74	6821	38	significantly	significantly	RB
cord-015021-pol2qm74	6821	39	increase	increase	VBP
cord-015021-pol2qm74	6821	40	hematocrils	hematocril	NNS
cord-015021-pol2qm74	6821	41	in	in	IN
cord-015021-pol2qm74	6821	42	children	child	NNS
cord-015021-pol2qm74	6821	43	following	follow	VBG
cord-015021-pol2qm74	6821	44	thermal	thermal	JJ
cord-015021-pol2qm74	6821	45	trauma	trauma	NN
cord-015021-pol2qm74	6821	46	and	and	CC
cord-015021-pol2qm74	6821	47	successfully	successfully	RB
cord-015021-pol2qm74	6821	48	increase	increase	VB
cord-015021-pol2qm74	6821	49	red	red	JJ
cord-015021-pol2qm74	6821	50	blood	blood	NN
cord-015021-pol2qm74	6821	51	cell	cell	NN
cord-015021-pol2qm74	6821	52	mass	mass	NN
cord-015021-pol2qm74	6821	53	following	follow	VBG
cord-015021-pol2qm74	6821	54	essential	essential	JJ
cord-015021-pol2qm74	6821	55	surgical	surgical	JJ
cord-015021-pol2qm74	6821	56	procedures	procedure	NNS
cord-015021-pol2qm74	6821	57	in	in	IN
cord-015021-pol2qm74	6821	58	patients	patient	NNS
cord-015021-pol2qm74	6821	59	with	with	IN
cord-015021-pol2qm74	6821	60	religious	religious	JJ
cord-015021-pol2qm74	6821	61	aversion	aversion	NN
cord-015021-pol2qm74	6821	62	to	to	IN
cord-015021-pol2qm74	6821	63	transfusion	transfusion	NN
cord-015021-pol2qm74	6821	64	.	.	.
cord-015021-pol2qm74	6822	1	BY	by	IN
cord-015021-pol2qm74	6822	2	BLOOD	blood	NN
cord-015021-pol2qm74	6822	3	TRANSFUSION	transfusion	NN
cord-015021-pol2qm74	6822	4	IN	in	IN
cord-015021-pol2qm74	6822	5	COLORECTAL	colorectal	JJ
cord-015021-pol2qm74	6822	6	CANCER	cancer	NN
cord-015021-pol2qm74	6822	7	SURGERY	surgery	NN
cord-015021-pol2qm74	6823	1	MM	MM	NNP
cord-015021-pol2qm74	6824	1	Heiss	Heiss	NNP
cord-015021-pol2qm74	6824	2	MD	MD	NNP
cord-015021-pol2qm74	6824	3	,	,	,
cord-015021-pol2qm74	6824	4	Ch	Ch	NNP
cord-015021-pol2qm74	6824	5	Delanoff	Delanoff	NNP
cord-015021-pol2qm74	6824	6	MD	MD	NNP
cord-015021-pol2qm74	6824	7	,	,	,
cord-015021-pol2qm74	6824	8	R	R	NNP
cord-015021-pol2qm74	6824	9	Stets	Stets	NNP
cord-015021-pol2qm74	6824	10	MD	MD	NNP
cord-015021-pol2qm74	6824	11	,	,	,
cord-015021-pol2qm74	6824	12	J	J	NNP
cord-015021-pol2qm74	6824	13	Hofinann	Hofinann	NNP
cord-015021-pol2qm74	6824	14	,	,	,
cord-015021-pol2qm74	6824	15	E	E	NNP
cord-015021-pol2qm74	6824	16	Faist	Faist	NNP
cord-015021-pol2qm74	6824	17	MD	MD	NNP
cord-015021-pol2qm74	6824	18	,	,	,
cord-015021-pol2qm74	6824	19	KW	KW	NNP
cord-015021-pol2qm74	6824	20	Jauch	Jauch	NNP
cord-015021-pol2qm74	6824	21	MD	MD	NNP
cord-015021-pol2qm74	6824	22	,	,	,
cord-015021-pol2qm74	6824	23	FW	FW	NNP
cord-015021-pol2qm74	6824	24	Schildberg	Schildberg	NNP
cord-015021-pol2qm74	6824	25	MD	MD	NNP
cord-015021-pol2qm74	6824	26	Allogeneic	Allogeneic	NNP
cord-015021-pol2qm74	6824	27	blood	blood	NN
cord-015021-pol2qm74	6824	28	transfusions	transfusion	NNS
cord-015021-pol2qm74	6824	29	are	be	VBP
cord-015021-pol2qm74	6824	30	associated	associate	VBN
cord-015021-pol2qm74	6824	31	with	with	IN
cord-015021-pol2qm74	6824	32	an	an	DT
cord-015021-pol2qm74	6824	33	increased	increase	VBN
cord-015021-pol2qm74	6824	34	risk	risk	NN
cord-015021-pol2qm74	6824	35	for	for	IN
cord-015021-pol2qm74	6824	36	postoperative	postoperative	JJ
cord-015021-pol2qm74	6824	37	infections	infection	NNS
cord-015021-pol2qm74	6824	38	in	in	IN
cord-015021-pol2qm74	6824	39	colorectal	colorectal	JJ
cord-015021-pol2qm74	6824	40	surgery	surgery	NN
cord-015021-pol2qm74	6824	41	when	when	WRB
cord-015021-pol2qm74	6824	42	compared	compare	VBN
cord-015021-pol2qm74	6824	43	with	with	IN
cord-015021-pol2qm74	6824	44	autologous	autologous	JJ
cord-015021-pol2qm74	6824	45	blood	blood	NN
cord-015021-pol2qm74	6824	46	transfusions	transfusion	NNS
cord-015021-pol2qm74	6824	47	.	.	.
cord-015021-pol2qm74	6825	1	Attribution	attribution	NN
cord-015021-pol2qm74	6825	2	of	of	IN
cord-015021-pol2qm74	6825	3	this	this	DT
cord-015021-pol2qm74	6825	4	effect	effect	NN
cord-015021-pol2qm74	6825	5	to	to	IN
cord-015021-pol2qm74	6825	6	immunomodulation	immunomodulation	NN
cord-015021-pol2qm74	6825	7	was	be	VBD
cord-015021-pol2qm74	6825	8	suspected	suspect	VBN
cord-015021-pol2qm74	6825	9	in	in	IN
cord-015021-pol2qm74	6825	10	our	-PRON-	PRP$
cord-015021-pol2qm74	6825	11	previous	previous	JJ
cord-015021-pol2qm74	6825	12	study	study	NN
cord-015021-pol2qm74	6825	13	(	(	-LRB-
cord-015021-pol2qm74	6825	14	Lancet	Lancet	NNP
cord-015021-pol2qm74	6825	15	1993	1993	CD
cord-015021-pol2qm74	6825	16	;	;	:
cord-015021-pol2qm74	6825	17	342:1328	342:1328	NNP
cord-015021-pol2qm74	6825	18	-	-	HYPH
cord-015021-pol2qm74	6825	19	33	33	CD
cord-015021-pol2qm74	6825	20	)	)	-RRB-
cord-015021-pol2qm74	6825	21	.	.	.
cord-015021-pol2qm74	6826	1	Task	task	NN
cord-015021-pol2qm74	6826	2	of	of	IN
cord-015021-pol2qm74	6826	3	the	the	DT
cord-015021-pol2qm74	6826	4	recent	recent	JJ
cord-015021-pol2qm74	6826	5	investigations	investigation	NNS
cord-015021-pol2qm74	6826	6	was	be	VBD
cord-015021-pol2qm74	6826	7	to	to	TO
cord-015021-pol2qm74	6826	8	analyze	analyze	VB
cord-015021-pol2qm74	6826	9	which	which	WDT
cord-015021-pol2qm74	6826	10	specific	specific	JJ
cord-015021-pol2qm74	6826	11	effector	effector	NN
cord-015021-pol2qm74	6826	12	systems	system	NNS
cord-015021-pol2qm74	6826	13	were	be	VBD
cord-015021-pol2qm74	6826	14	affected	affect	VBN
cord-015021-pol2qm74	6826	15	in	in	IN
cord-015021-pol2qm74	6826	16	-	-	HYPH
cord-015021-pol2qm74	6826	17	vivo	vivo	NN
cord-015021-pol2qm74	6826	18	by	by	IN
cord-015021-pol2qm74	6826	19	this	this	DT
cord-015021-pol2qm74	6826	20	transfusion	transfusion	NN
cord-015021-pol2qm74	6826	21	-	-	HYPH
cord-015021-pol2qm74	6826	22	associated	associate	VBN
cord-015021-pol2qm74	6826	23	modulation	modulation	NN
cord-015021-pol2qm74	6826	24	.	.	.
cord-015021-pol2qm74	6827	1	For	for	IN
cord-015021-pol2qm74	6827	2	global	global	JJ
cord-015021-pol2qm74	6827	3	in	in	IN
cord-015021-pol2qm74	6827	4	-	-	HYPH
cord-015021-pol2qm74	6827	5	viva	viva	FW
cord-015021-pol2qm74	6827	6	assessment	assessment	NN
cord-015021-pol2qm74	6827	7	of	of	IN
cord-015021-pol2qm74	6827	8	cell	cell	NN
cord-015021-pol2qm74	6827	9	-	-	HYPH
cord-015021-pol2qm74	6827	10	mediated	mediate	VBN
cord-015021-pol2qm74	6827	11	immunity	immunity	NN
cord-015021-pol2qm74	6827	12	(	(	-LRB-
cord-015021-pol2qm74	6827	13	CMI	CMI	NNP
cord-015021-pol2qm74	6827	14	)	)	-RRB-
cord-015021-pol2qm74	6828	1	multiple	multiple	JJ
cord-015021-pol2qm74	6828	2	recall	recall	NN
cord-015021-pol2qm74	6829	1	skin	skin	NN
cord-015021-pol2qm74	6829	2	-	-	HYPH
cord-015021-pol2qm74	6829	3	reactions	reaction	NNS
cord-015021-pol2qm74	6829	4	were	be	VBD
cord-015021-pol2qm74	6829	5	applied	apply	VBN
cord-015021-pol2qm74	6829	6	prior	prior	RB
cord-015021-pol2qm74	6829	7	and	and	CC
cord-015021-pol2qm74	6829	8	post	post	JJ
cord-015021-pol2qm74	6829	9	-	-	JJ
cord-015021-pol2qm74	6829	10	operative	operative	JJ
cord-015021-pol2qm74	6829	11	.	.	.
cord-015021-pol2qm74	6830	1	The	the	DT
cord-015021-pol2qm74	6830	2	specific	specific	JJ
cord-015021-pol2qm74	6830	3	humoral	humoral	JJ
cord-015021-pol2qm74	6830	4	immune	immune	JJ
cord-015021-pol2qm74	6830	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6830	6	were	be	VBD
cord-015021-pol2qm74	6830	7	investigated	investigate	VBN
cord-015021-pol2qm74	6830	8	by	by	IN
cord-015021-pol2qm74	6830	9	applying	apply	VBG
cord-015021-pol2qm74	6830	10	Tetanus	Tetanus	NNP
cord-015021-pol2qm74	6830	11	-	-	HYPH
cord-015021-pol2qm74	6830	12	Toxoid	Toxoid	NNP
cord-015021-pol2qm74	6830	13	one	one	CD
cord-015021-pol2qm74	6830	14	day	day	NN
cord-015021-pol2qm74	6830	15	preoperatively	preoperatively	NN
cord-015021-pol2qm74	6830	16	and	and	CC
cord-015021-pol2qm74	6830	17	deterimnating	deterimnate	VBG
cord-015021-pol2qm74	6830	18	the	the	DT
cord-015021-pol2qm74	6830	19	quantitative	quantitative	JJ
cord-015021-pol2qm74	6830	20	IgG	igg	NN
cord-015021-pol2qm74	6830	21	-	-	HYPH
cord-015021-pol2qm74	6830	22	response	response	NN
cord-015021-pol2qm74	6830	23	.	.	.
cord-015021-pol2qm74	6831	1	For	for	IN
cord-015021-pol2qm74	6831	2	indication	indication	NN
cord-015021-pol2qm74	6831	3	of	of	IN
cord-015021-pol2qm74	6831	4	macrophage	macrophage	NN
cord-015021-pol2qm74	6831	5	stimulation	stimulation	NN
cord-015021-pol2qm74	6831	6	in	in	IN
cord-015021-pol2qm74	6831	7	-	-	HYPH
cord-015021-pol2qm74	6831	8	vivo	vivo	NNP
cord-015021-pol2qm74	6831	9	TNF	tnf	NN
cord-015021-pol2qm74	6831	10	-	-	HYPH
cord-015021-pol2qm74	6831	11	levels	level	NNS
cord-015021-pol2qm74	6831	12	were	be	VBD
cord-015021-pol2qm74	6831	13	determinated	determinate	VBN
cord-015021-pol2qm74	6831	14	by	by	IN
cord-015021-pol2qm74	6831	15	bioassay	bioassay	NN
cord-015021-pol2qm74	6831	16	.	.	.
cord-015021-pol2qm74	6832	1	DTH	DTH	NNP
cord-015021-pol2qm74	6832	2	-	-	HYPH
cord-015021-pol2qm74	6832	3	responses	response	NNS
cord-015021-pol2qm74	6832	4	were	be	VBD
cord-015021-pol2qm74	6832	5	significantly	significantly	RB
cord-015021-pol2qm74	6832	6	suppressed	suppress	VBN
cord-015021-pol2qm74	6832	7	(	(	-LRB-
cord-015021-pol2qm74	6832	8	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6832	9	)	)	-RRB-
cord-015021-pol2qm74	6832	10	in	in	IN
cord-015021-pol2qm74	6832	11	patients	patient	NNS
cord-015021-pol2qm74	6832	12	receiving	receive	VBG
cord-015021-pol2qm74	6832	13	allogeneic	allogeneic	IN
cord-015021-pol2qm74	6832	14	blood	blood	NN
cord-015021-pol2qm74	6832	15	(	(	-LRB-
cord-015021-pol2qm74	6832	16	n=36	n=36	NNS
cord-015021-pol2qm74	6832	17	)	)	-RRB-
cord-015021-pol2qm74	6832	18	or	or	CC
cord-015021-pol2qm74	6832	19	operated	operate	VBN
cord-015021-pol2qm74	6832	20	without	without	IN
cord-015021-pol2qm74	6832	21	blood	blood	NN
cord-015021-pol2qm74	6832	22	transfusions	transfusion	NNS
cord-015021-pol2qm74	6832	23	(	(	-LRB-
cord-015021-pol2qm74	6832	24	n=17	n=17	NNP
cord-015021-pol2qm74	6832	25	)	)	-RRB-
cord-015021-pol2qm74	6832	26	.	.	.
cord-015021-pol2qm74	6833	1	DTHresponses	DTHresponses	NNP
cord-015021-pol2qm74	6833	2	were	be	VBD
cord-015021-pol2qm74	6833	3	not	not	RB
cord-015021-pol2qm74	6833	4	suppressed	suppress	VBN
cord-015021-pol2qm74	6833	5	and	and	CC
cord-015021-pol2qm74	6833	6	tendentiously	tendentiously	RB
cord-015021-pol2qm74	6833	7	increased	increase	VBN
cord-015021-pol2qm74	6833	8	in	in	IN
cord-015021-pol2qm74	6833	9	patients	patient	NNS
cord-015021-pol2qm74	6833	10	with	with	IN
cord-015021-pol2qm74	6833	11	autologous	autologous	JJ
cord-015021-pol2qm74	6833	12	blood	blood	NN
cord-015021-pol2qm74	6833	13	transfusions	transfusion	NNS
cord-015021-pol2qm74	6833	14	(	(	-LRB-
cord-015021-pol2qm74	6833	15	n=24	n=24	NNP
cord-015021-pol2qm74	6833	16	)	)	-RRB-
cord-015021-pol2qm74	6833	17	.	.	.
cord-015021-pol2qm74	6834	1	In	in	IN
cord-015021-pol2qm74	6834	2	contrast	contrast	NN
cord-015021-pol2qm74	6834	3	,	,	,
cord-015021-pol2qm74	6834	4	specific	specific	JJ
cord-015021-pol2qm74	6834	5	IgG	igg	NN
cord-015021-pol2qm74	6834	6	-	-	HYPH
cord-015021-pol2qm74	6834	7	levels	level	NNS
cord-015021-pol2qm74	6834	8	increased	increase	VBN
cord-015021-pol2qm74	6834	9	sigmficantly	sigmficantly	RB
cord-015021-pol2qm74	6834	10	(	(	-LRB-
cord-015021-pol2qm74	6834	11	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6834	12	)	)	-RRB-
cord-015021-pol2qm74	6834	13	in	in	IN
cord-015021-pol2qm74	6834	14	patients	patient	NNS
cord-015021-pol2qm74	6834	15	receiving	receive	VBG
cord-015021-pol2qm74	6834	16	allogeneie	allogeneie	NN
cord-015021-pol2qm74	6834	17	blood	blood	NN
cord-015021-pol2qm74	6834	18	(	(	-LRB-
cord-015021-pol2qm74	6834	19	from	from	IN
cord-015021-pol2qm74	6834	20	1.6	1.6	CD
cord-015021-pol2qm74	6834	21	+	+	SYM
cord-015021-pol2qm74	6834	22	4.4	4.4	CD
cord-015021-pol2qm74	6834	23	to	to	TO
cord-015021-pol2qm74	6834	24	9.7	9.7	CD
cord-015021-pol2qm74	6834	25	_	_	NN
cord-015021-pol2qm74	6834	26	+	+	SYM
cord-015021-pol2qm74	6834	27	18.4	18.4	CD
cord-015021-pol2qm74	6834	28	IE	IE	NNP
cord-015021-pol2qm74	6834	29	/	/	SYM
cord-015021-pol2qm74	6834	30	ml	ml	NN
cord-015021-pol2qm74	6834	31	)	)	-RRB-
cord-015021-pol2qm74	6834	32	whereas	whereas	IN
cord-015021-pol2qm74	6834	33	in	in	IN
cord-015021-pol2qm74	6834	34	patients	patient	NNS
cord-015021-pol2qm74	6834	35	receiving	receive	VBG
cord-015021-pol2qm74	6834	36	autologous	autologous	JJ
cord-015021-pol2qm74	6834	37	blood	blood	NN
cord-015021-pol2qm74	6834	38	a	a	DT
cord-015021-pol2qm74	6834	39	smaller	small	JJR
cord-015021-pol2qm74	6834	40	increase	increase	NN
cord-015021-pol2qm74	6834	41	(	(	-LRB-
cord-015021-pol2qm74	6834	42	from	from	IN
cord-015021-pol2qm74	6834	43	1.9	1.9	CD
cord-015021-pol2qm74	6834	44	+	+	SYM
cord-015021-pol2qm74	6834	45	4.1	4.1	CD
cord-015021-pol2qm74	6834	46	to	to	TO
cord-015021-pol2qm74	6834	47	4.0	4.0	CD
cord-015021-pol2qm74	6834	48	+	+	SYM
cord-015021-pol2qm74	6834	49	6.7	6.7	CD
cord-015021-pol2qm74	6834	50	;	;	:
cord-015021-pol2qm74	6834	51	p=0.068	p=0.068	NN
cord-015021-pol2qm74	6834	52	)	)	-RRB-
cord-015021-pol2qm74	6834	53	was	be	VBD
cord-015021-pol2qm74	6834	54	observed	observe	VBN
cord-015021-pol2qm74	6834	55	.	.	.
cord-015021-pol2qm74	6835	1	TNFlevels	TNFlevels	NNP
cord-015021-pol2qm74	6835	2	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	6835	3	a	a	DT
cord-015021-pol2qm74	6835	4	similar	similar	JJ
cord-015021-pol2qm74	6835	5	pattern	pattern	NN
cord-015021-pol2qm74	6835	6	with	with	IN
cord-015021-pol2qm74	6835	7	a	a	DT
cord-015021-pol2qm74	6835	8	higher	high	JJR
cord-015021-pol2qm74	6835	9	increase	increase	NN
cord-015021-pol2qm74	6835	10	in	in	IN
cord-015021-pol2qm74	6835	11	patients	patient	NNS
cord-015021-pol2qm74	6835	12	receiving	receive	VBG
cord-015021-pol2qm74	6835	13	allogeneic	allogeneic	NN
cord-015021-pol2qm74	6835	14	transfusions	transfusion	NNS
cord-015021-pol2qm74	6835	15	(	(	-LRB-
cord-015021-pol2qm74	6835	16	l	l	NN
cord-015021-pol2qm74	6835	17	1.4	1.4	CD
cord-015021-pol2qm74	6835	18	+	+	SYM
cord-015021-pol2qm74	6835	19	12.0	12.0	CD
cord-015021-pol2qm74	6835	20	to	to	IN
cord-015021-pol2qm74	6835	21	28.5	28.5	CD
cord-015021-pol2qm74	6835	22	+	+	SYM
cord-015021-pol2qm74	6835	23	11.4	11.4	CD
cord-015021-pol2qm74	6835	24	u	u	NNP
cord-015021-pol2qm74	6835	25	/	/	SYM
cord-015021-pol2qm74	6835	26	ml	ml	NN
cord-015021-pol2qm74	6835	27	)	)	-RRB-
cord-015021-pol2qm74	6835	28	compared	compare	VBN
cord-015021-pol2qm74	6835	29	to	to	IN
cord-015021-pol2qm74	6835	30	those	those	DT
cord-015021-pol2qm74	6835	31	patients	patient	NNS
cord-015021-pol2qm74	6835	32	with	with	IN
cord-015021-pol2qm74	6835	33	autologous	autologous	JJ
cord-015021-pol2qm74	6835	34	blood	blood	NN
cord-015021-pol2qm74	6835	35	(	(	-LRB-
cord-015021-pol2qm74	6835	36	8.7	8.7	CD
cord-015021-pol2qm74	6835	37	+	+	SYM
cord-015021-pol2qm74	6835	38	12.5	12.5	CD
cord-015021-pol2qm74	6835	39	to	to	IN
cord-015021-pol2qm74	6835	40	17.1	17.1	CD
cord-015021-pol2qm74	6835	41	+	+	CD
cord-015021-pol2qm74	6835	42	23.0	23.0	CD
cord-015021-pol2qm74	6835	43	)	)	-RRB-
cord-015021-pol2qm74	6835	44	.	.	.
cord-015021-pol2qm74	6836	1	In	in	IN
cord-015021-pol2qm74	6836	2	conclusion	conclusion	NN
cord-015021-pol2qm74	6836	3	these	these	DT
cord-015021-pol2qm74	6836	4	data	datum	NNS
cord-015021-pol2qm74	6836	5	indicate	indicate	VBP
cord-015021-pol2qm74	6836	6	that	that	IN
cord-015021-pol2qm74	6836	7	allogeneic	allogeneic	IN
cord-015021-pol2qm74	6836	8	blood	blood	NN
cord-015021-pol2qm74	6836	9	transfusions	transfusion	NNS
cord-015021-pol2qm74	6836	10	lead	lead	VBP
cord-015021-pol2qm74	6836	11	to	to	IN
cord-015021-pol2qm74	6836	12	a	a	DT
cord-015021-pol2qm74	6836	13	remarkable	remarkable	JJ
cord-015021-pol2qm74	6836	14	macrophage	macrophage	NN
cord-015021-pol2qm74	6836	15	/	/	SYM
cord-015021-pol2qm74	6836	16	RHS	RHS	NNP
cord-015021-pol2qm74	6836	17	stimulation	stimulation	NN
cord-015021-pol2qm74	6836	18	.	.	.
cord-015021-pol2qm74	6837	1	This	this	DT
cord-015021-pol2qm74	6837	2	is	be	VBZ
cord-015021-pol2qm74	6837	3	corroborated	corroborate	VBN
cord-015021-pol2qm74	6837	4	by	by	IN
cord-015021-pol2qm74	6837	5	the	the	DT
cord-015021-pol2qm74	6837	6	boostered	boostered	NNP
cord-015021-pol2qm74	6837	7	humoral	humoral	NNP
cord-015021-pol2qm74	6837	8	IgG	IgG	NNP
cord-015021-pol2qm74	6837	9	-	-	HYPH
cord-015021-pol2qm74	6837	10	response	response	NN
cord-015021-pol2qm74	6837	11	which	which	WDT
cord-015021-pol2qm74	6837	12	was	be	VBD
cord-015021-pol2qm74	6837	13	initiated	initiate	VBN
cord-015021-pol2qm74	6837	14	before	before	IN
cord-015021-pol2qm74	6837	15	onset	onset	NN
cord-015021-pol2qm74	6837	16	of	of	IN
cord-015021-pol2qm74	6837	17	surgical	surgical	JJ
cord-015021-pol2qm74	6837	18	trauma	trauma	NN
cord-015021-pol2qm74	6837	19	and	and	CC
cord-015021-pol2qm74	6837	20	blood	blood	NN
cord-015021-pol2qm74	6837	21	transfusion	transfusion	NN
cord-015021-pol2qm74	6837	22	.	.	.
cord-015021-pol2qm74	6838	1	Concerning	concern	VBG
cord-015021-pol2qm74	6838	2	CMI	CMI	NNP
cord-015021-pol2qm74	6839	1	this	this	DT
cord-015021-pol2qm74	6839	2	caused	cause	VBD
cord-015021-pol2qm74	6839	3	a	a	DT
cord-015021-pol2qm74	6839	4	substancial	substancial	JJ
cord-015021-pol2qm74	6839	5	suppression	suppression	NN
cord-015021-pol2qm74	6839	6	probably	probably	RB
cord-015021-pol2qm74	6839	7	due	due	IN
cord-015021-pol2qm74	6839	8	to	to	IN
cord-015021-pol2qm74	6839	9	a	a	DT
cord-015021-pol2qm74	6839	10	stimulated	stimulated	JJ
cord-015021-pol2qm74	6839	11	secretion	secretion	NN
cord-015021-pol2qm74	6839	12	of	of	IN
cord-015021-pol2qm74	6839	13	immunosuppressive	immunosuppressive	JJ
cord-015021-pol2qm74	6839	14	monokines	monokine	NNS
cord-015021-pol2qm74	6839	15	.	.	.
cord-015021-pol2qm74	6840	1	Objective	objective	NN
cord-015021-pol2qm74	6840	2	:	:	:
cord-015021-pol2qm74	6841	1	Firstly	firstly	RB
cord-015021-pol2qm74	6841	2	,	,	,
cord-015021-pol2qm74	6841	3	to	to	TO
cord-015021-pol2qm74	6841	4	analyse	analyse	VB
cord-015021-pol2qm74	6841	5	the	the	DT
cord-015021-pol2qm74	6841	6	concentrations	concentration	NNS
cord-015021-pol2qm74	6841	7	of	of	IN
cord-015021-pol2qm74	6841	8	the	the	DT
cord-015021-pol2qm74	6841	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	6841	10	tumor	tumor	NN
cord-015021-pol2qm74	6841	11	necrosis	necrosis	NN
cord-015021-pol2qm74	6841	12	factor	factor	NN
cord-015021-pol2qm74	6841	13	(	(	-LRB-
cord-015021-pol2qm74	6841	14	TNc	TNc	NNP
cord-015021-pol2qm74	6841	15	)	)	-RRB-
cord-015021-pol2qm74	6841	16	,	,	,
cord-015021-pol2qm74	6841	17	interleukin-1	interleukin-1	FW
cord-015021-pol2qm74	6841	18	(	(	-LRB-
cord-015021-pol2qm74	6841	19	IL	IL	NNP
cord-015021-pol2qm74	6841	20	-	-	HYPH
cord-015021-pol2qm74	6841	21	I	I	NNP
cord-015021-pol2qm74	6841	22	)	)	-RRB-
cord-015021-pol2qm74	6841	23	,	,	,
cord-015021-pol2qm74	6841	24	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	6841	25	(	(	-LRB-
cord-015021-pol2qm74	6841	26	IL-6	IL-6	NNP
cord-015021-pol2qm74	6841	27	)	)	-RRB-
cord-015021-pol2qm74	6841	28	and	and	CC
cord-015021-pol2qm74	6841	29	coagulatioo	coagulatioo	NNP
cord-015021-pol2qm74	6841	30	/	/	SYM
cord-015021-pol2qm74	6841	31	fibrinolysis	fibrinolysis	NN
cord-015021-pol2qm74	6841	32	parameters	parameter	NNS
cord-015021-pol2qm74	6841	33	in	in	IN
cord-015021-pol2qm74	6841	34	postoperatively	postoperatively	RB
cord-015021-pol2qm74	6841	35	retrieved	retrieve	VBN
cord-015021-pol2qm74	6841	36	blood	blood	NN
cord-015021-pol2qm74	6841	37	from	from	IN
cord-015021-pol2qm74	6841	38	a	a	DT
cord-015021-pol2qm74	6841	39	surgical	surgical	JJ
cord-015021-pol2qm74	6841	40	area	area	NN
cord-015021-pol2qm74	6841	41	,	,	,
cord-015021-pol2qm74	6841	42	secondly	secondly	RB
cord-015021-pol2qm74	6841	43	to	to	TO
cord-015021-pol2qm74	6841	44	characterize	characterize	VB
cord-015021-pol2qm74	6841	45	the	the	DT
cord-015021-pol2qm74	6841	46	correspanding	correspande	VBG
cord-015021-pol2qm74	6841	47	cytokine	cytokine	NN
cord-015021-pol2qm74	6841	48	patters	patter	NNS
cord-015021-pol2qm74	6841	49	in	in	IN
cord-015021-pol2qm74	6841	50	the	the	DT
cord-015021-pol2qm74	6841	51	patients	patient	NNS
cord-015021-pol2qm74	6841	52	and	and	CC
cord-015021-pol2qm74	6841	53	thirdly	thirdly	RB
cord-015021-pol2qm74	6841	54	to	to	TO
cord-015021-pol2qm74	6841	55	study	study	VB
cord-015021-pol2qm74	6841	56	cytokine	cytokine	JJ
cord-015021-pol2qm74	6841	57	concentrations	concentration	NNS
cord-015021-pol2qm74	6841	58	in	in	IN
cord-015021-pol2qm74	6841	59	the	the	DT
cord-015021-pol2qm74	6841	60	initial	initial	JJ
cord-015021-pol2qm74	6841	61	portion	portion	NN
cord-015021-pol2qm74	6841	62	of	of	IN
cord-015021-pol2qm74	6841	63	drainage	drainage	NN
cord-015021-pol2qm74	6841	64	blood	blood	NN
cord-015021-pol2qm74	6841	65	from	from	IN
cord-015021-pol2qm74	6841	66	a	a	DT
cord-015021-pol2qm74	6841	67	surgical	surgical	JJ
cord-015021-pol2qm74	6841	68	area	area	NN
cord-015021-pol2qm74	6841	69	.	.	.
cord-015021-pol2qm74	6842	1	Materials	material	NNS
cord-015021-pol2qm74	6842	2	and	and	CC
cord-015021-pol2qm74	6842	3	Methods	method	NNS
cord-015021-pol2qm74	6842	4	:	:	:
cord-015021-pol2qm74	6842	5	Blood	blood	NN
cord-015021-pol2qm74	6842	6	retrieval	retrieval	NN
cord-015021-pol2qm74	6842	7	was	be	VBD
cord-015021-pol2qm74	6842	8	performed	perform	VBN
cord-015021-pol2qm74	6842	9	in	in	IN
cord-015021-pol2qm74	6842	10	a	a	DT
cord-015021-pol2qm74	6842	11	closed	closed	JJ
cord-015021-pol2qm74	6842	12	-	-	HYPH
cord-015021-pol2qm74	6842	13	loop	loop	NN
cord-015021-pol2qm74	6842	14	system	system	NN
cord-015021-pol2qm74	6842	15	without	without	IN
cord-015021-pol2qm74	6842	16	anticoagulant	anticoagulant	NN
cord-015021-pol2qm74	6842	17	during	during	IN
cord-015021-pol2qm74	6842	18	4	4	CD
cord-015021-pol2qm74	6842	19	-	-	SYM
cord-015021-pol2qm74	6842	20	6	6	CD
cord-015021-pol2qm74	6842	21	hours	hour	NNS
cord-015021-pol2qm74	6842	22	after	after	IN
cord-015021-pol2qm74	6842	23	surgery	surgery	NN
cord-015021-pol2qm74	6842	24	in	in	IN
cord-015021-pol2qm74	6842	25	10	10	CD
cord-015021-pol2qm74	6842	26	patients	patient	NNS
cord-015021-pol2qm74	6842	27	undergoing	undergo	VBG
cord-015021-pol2qm74	6842	28	arthroplasty	arthroplasty	NNP
cord-015021-pol2qm74	6842	29	(	(	-LRB-
cord-015021-pol2qm74	6842	30	9	9	CD
cord-015021-pol2qm74	6842	31	hips	hip	NNS
cord-015021-pol2qm74	6842	32	and	and	CC
cord-015021-pol2qm74	6842	33	1	1	CD
cord-015021-pol2qm74	6842	34	knee	knee	NN
cord-015021-pol2qm74	6842	35	)	)	-RRB-
cord-015021-pol2qm74	6842	36	.	.	.
cord-015021-pol2qm74	6843	1	7KF	7kf	CD
cord-015021-pol2qm74	6843	2	,	,	,
cord-015021-pol2qm74	6843	3	IL-1	IL-1	NNP
cord-015021-pol2qm74	6843	4	,	,	,
cord-015021-pol2qm74	6843	5	It-6	It-6	NNP
cord-015021-pol2qm74	6843	6	,	,	,
cord-015021-pol2qm74	6843	7	thrembin	thrembin	NN
cord-015021-pol2qm74	6843	8	-	-	HYPH
cord-015021-pol2qm74	6843	9	antithrombin	antithrombin	NN
cord-015021-pol2qm74	6843	10	complexes	complex	NNS
cord-015021-pol2qm74	6843	11	(	(	-LRB-
cord-015021-pol2qm74	6843	12	TAC	TAC	NNP
cord-015021-pol2qm74	6843	13	)	)	-RRB-
cord-015021-pol2qm74	6843	14	and	and	CC
cord-015021-pol2qm74	6843	15	antithrombin	antithrombin	NN
cord-015021-pol2qm74	6843	16	(	(	-LRB-
cord-015021-pol2qm74	6843	17	AT	at	IN
cord-015021-pol2qm74	6843	18	)	)	-RRB-
cord-015021-pol2qm74	6844	1	~ere	~ere	NNP
cord-015021-pol2qm74	6844	2	determined	determine	VBN
cord-015021-pol2qm74	6844	3	in	in	IN
cord-015021-pol2qm74	6844	4	shed	shed	JJ
cord-015021-pol2qm74	6844	5	blood	blood	NN
cord-015021-pol2qm74	6844	6	.	.	.
cord-015021-pol2qm74	6845	1	Patient	Patient	NNP
cord-015021-pol2qm74	6845	2	plasma	plasma	NN
cord-015021-pol2qm74	6845	3	TN	TN	NNP
cord-015021-pol2qm74	6845	4	v	v	NN
cord-015021-pol2qm74	6845	5	,	,	,
cord-015021-pol2qm74	6845	6	IL	IL	NNP
cord-015021-pol2qm74	6845	7	-	-	HYPH
cord-015021-pol2qm74	6845	8	I	I	NNP
cord-015021-pol2qm74	6845	9	and	and	CC
cord-015021-pol2qm74	6845	10	IL-6	IL-6	NNP
cord-015021-pol2qm74	6845	11	concentrations	concentration	NNS
cord-015021-pol2qm74	6846	1	~ere	~ere	NNP
cord-015021-pol2qm74	6846	2	analysed	analyse	VBD
cord-015021-pol2qm74	6846	3	at	at	IN
cord-015021-pol2qm74	6846	4	the	the	DT
cord-015021-pol2qm74	6846	5	beginnLqg	beginnlqg	NN
cord-015021-pol2qm74	6846	6	and	and	CC
cord-015021-pol2qm74	6846	7	end	end	NN
cord-015021-pol2qm74	6846	8	of	of	IN
cord-015021-pol2qm74	6846	9	the	the	DT
cord-015021-pol2qm74	6846	10	4	4	CD
cord-015021-pol2qm74	6846	11	-	-	SYM
cord-015021-pol2qm74	6846	12	6	6	CD
cord-015021-pol2qm74	6846	13	hour	hour	NN
cord-015021-pol2qm74	6846	14	blood	blood	NN
cord-015021-pol2qm74	6846	15	retrieval	retrieval	NN
cord-015021-pol2qm74	6846	16	period	period	NN
cord-015021-pol2qm74	6846	17	.	.	.
cord-015021-pol2qm74	6847	1	In	in	IN
cord-015021-pol2qm74	6847	2	a	a	DT
cord-015021-pol2qm74	6847	3	separate	separate	JJ
cord-015021-pol2qm74	6847	4	study	study	NN
cord-015021-pol2qm74	6847	5	(	(	-LRB-
cord-015021-pol2qm74	6847	6	5	5	CD
cord-015021-pol2qm74	6847	7	hip	hip	NN
cord-015021-pol2qm74	6847	8	arthroplasties	arthroplasty	NNS
cord-015021-pol2qm74	6847	9	)	)	-RRB-
cord-015021-pol2qm74	6848	1	f	f	LS
cord-015021-pol2qm74	6848	2	~	~	NFP
cord-015021-pol2qm74	6848	3	F	F	NNP
cord-015021-pol2qm74	6848	4	,	,	,
cord-015021-pol2qm74	6848	5	IL	IL	NNP
cord-015021-pol2qm74	6848	6	-	-	:
cord-015021-pol2qm74	6848	7	I	I	NNP
cord-015021-pol2qm74	6848	8	and	and	CC
cord-015021-pol2qm74	6849	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	6849	2	~ere	~ere	NNP
cord-015021-pol2qm74	6849	3	determined	determine	VBN
cord-015021-pol2qm74	6849	4	in	in	IN
cord-015021-pol2qm74	6849	5	the	the	DT
cord-015021-pol2qm74	6849	6	initial	initial	JJ
cord-015021-pol2qm74	6849	7	portion	portion	NN
cord-015021-pol2qm74	6849	8	of	of	IN
cord-015021-pol2qm74	6849	9	drainage	drainage	NN
cord-015021-pol2qm74	6849	10	blood	blood	NN
cord-015021-pol2qm74	6849	11	.	.	.
cord-015021-pol2qm74	6850	1	Cytekine	cytekine	NN
cord-015021-pol2qm74	6850	2	analyses	analysis	NNS
cord-015021-pol2qm74	6850	3	~re	~re	NNP
cord-015021-pol2qm74	6850	4	performed	perform	VBD
cord-015021-pol2qm74	6850	5	usiog	usiog	NNP
cord-015021-pol2qm74	6850	6	ipmuooassays	ipmuooassays	NNP
cord-015021-pol2qm74	6850	7	.	.	.
cord-015021-pol2qm74	6851	1	An	an	DT
cord-015021-pol2qm74	6851	2	omidolytic	omidolytic	JJ
cord-015021-pol2qm74	6851	3	method	method	NN
cord-015021-pol2qm74	6851	4	was	be	VBD
cord-015021-pol2qm74	6851	5	used	use	VBN
cord-015021-pol2qm74	6851	6	for	for	IN
cord-015021-pol2qm74	6851	7	AT	AT	NNP
cord-015021-pol2qm74	6851	8	determinaf.ion	determinaf.ion	NNP
cord-015021-pol2qm74	6851	9	and	and	CC
cord-015021-pol2qm74	6851	10	TAC	TAC	NNP
cord-015021-pol2qm74	6851	11	was	be	VBD
cord-015021-pol2qm74	6851	12	analysed	analyse	VBN
cord-015021-pol2qm74	6851	13	by	by	IN
cord-015021-pol2qm74	6851	14	ELISA	ELISA	NNP
cord-015021-pol2qm74	6851	15	.	.	.
cord-015021-pol2qm74	6852	1	N	N	NNP
cord-015021-pol2qm74	6852	2	~	~	CD
cord-015021-pol2qm74	6852	3	n	n	NN
cord-015021-pol2qm74	6852	4	-	-	HYPH
cord-015021-pol2qm74	6852	5	poram	poram	NNP
cord-015021-pol2qm74	6852	6	~	~	NFP
cord-015021-pol2qm74	6852	7	tric	tric	JJ
cord-015021-pol2qm74	6852	8	tests	test	NNS
cord-015021-pol2qm74	6852	9	was	be	VBD
cord-015021-pol2qm74	6852	10	used	use	VBN
cord-015021-pol2qm74	6852	11	for	for	IN
cord-015021-pol2qm74	6852	12	the	the	DT
cord-015021-pol2qm74	6852	13	statistical	statistical	JJ
cord-015021-pol2qm74	6852	14	comparison	comparison	NN
cord-015021-pol2qm74	6852	15	.	.	.
cord-015021-pol2qm74	6853	1	Results	result	NNS
cord-015021-pol2qm74	6853	2	:	:	:
cord-015021-pol2qm74	6854	1	The	the	DT
cord-015021-pol2qm74	6854	2	patient	patient	NN
cord-015021-pol2qm74	6854	3	plasma	plasma	NN
cord-015021-pol2qm74	6854	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	6854	5	coocemtratiems	coocemtratiem	NNS
cord-015021-pol2qm74	6854	6	rose	rise	VBD
cord-015021-pol2qm74	6854	7	from	from	IN
cord-015021-pol2qm74	6854	8	a	a	DT
cord-015021-pol2qm74	6854	9	median	median	JJ
cord-015021-pol2qm74	6854	10	value	value	NN
cord-015021-pol2qm74	6854	11	of	of	IN
cord-015021-pol2qm74	6854	12	0	0	CD
cord-015021-pol2qm74	6854	13	to	to	IN
cord-015021-pol2qm74	6854	14	116	116	CD
cord-015021-pol2qm74	6854	15	pg	pg	NN
cord-015021-pol2qm74	6854	16	/	/	SYM
cord-015021-pol2qm74	6854	17	ml	ml	NN
cord-015021-pol2qm74	6854	18	,	,	,
cord-015021-pol2qm74	6854	19	p	p	NN
cord-015021-pol2qm74	6854	20	<	<	XX
cord-015021-pol2qm74	6855	1	O.01	o.01	CD
cord-015021-pol2qm74	6855	2	,	,	,
cord-015021-pol2qm74	6855	3	during	during	IN
cord-015021-pol2qm74	6855	4	the	the	DT
cord-015021-pol2qm74	6855	5	blood	blood	NN
cord-015021-pol2qm74	6855	6	ret.rieval	ret.rieval	NNP
cord-015021-pol2qm74	6855	7	period	period	NN
cord-015021-pol2qm74	6855	8	.	.	.
cord-015021-pol2qm74	6856	1	IN	in	IN
cord-015021-pol2qm74	6856	2	c	c	NNP
cord-015021-pol2qm74	6856	3	was	be	VBD
cord-015021-pol2qm74	6856	4	detectable	detectable	JJ
cord-015021-pol2qm74	6856	5	in	in	IN
cord-015021-pol2qm74	6856	6	4	4	CD
cord-015021-pol2qm74	6856	7	patients	patient	NNS
cord-015021-pol2qm74	6856	8	,	,	,
cord-015021-pol2qm74	6856	9	range:15	range:15	NNP
cord-015021-pol2qm74	6856	10	-	-	HYPH
cord-015021-pol2qm74	6856	11	50	50	CD
cord-015021-pol2qm74	6856	12	pg	pg	NN
cord-015021-pol2qm74	6856	13	/	/	SYM
cord-015021-pol2qm74	6856	14	ml	ml	NN
cord-015021-pol2qm74	6856	15	.	.	.
cord-015021-pol2qm74	6857	1	IL	IL	NNP
cord-015021-pol2qm74	6857	2	-	-	:
cord-015021-pol2qm74	6857	3	I	-PRON-	PRP
cord-015021-pol2qm74	6857	4	was	be	VBD
cord-015021-pol2qm74	6857	5	not	not	RB
cord-015021-pol2qm74	6857	6	detectable	detectable	JJ
cord-015021-pol2qm74	6857	7	in	in	IN
cord-015021-pol2qm74	6857	8	the	the	DT
cord-015021-pol2qm74	6857	9	patients	patient	NNS
cord-015021-pol2qm74	6857	10	.	.	.
cord-015021-pol2qm74	6858	1	In	in	IN
cord-015021-pol2qm74	6858	2	retrieved	retrieve	VBN
cord-015021-pol2qm74	6858	3	blood	blood	NN
cord-015021-pol2qm74	6858	4	TAG	tag	NN
cord-015021-pol2qm74	6858	5	was	be	VBD
cord-015021-pol2qm74	6858	6	>	>	NFP
cord-015021-pol2qm74	6858	7	200	200	CD
cord-015021-pol2qm74	6858	8	mg	mg	NNP
cord-015021-pol2qm74	6858	9	/	/	SYM
cord-015021-pol2qm74	6858	10	ml	ml	XX
cord-015021-pol2qm74	6858	11	in	in	IN
cord-015021-pol2qm74	6858	12	all	all	DT
cord-015021-pol2qm74	6858	13	samples	sample	NNS
cord-015021-pol2qm74	6859	1	(	(	-LRB-
cord-015021-pol2qm74	6859	2	ref:<4.1	ref:<4.1	NNP
cord-015021-pol2qm74	6859	3	mg	mg	NNP
cord-015021-pol2qm74	6859	4	/	/	SYM
cord-015021-pol2qm74	6859	5	ml	ml	NNP
cord-015021-pol2qm74	6859	6	)	)	-RRB-
cord-015021-pol2qm74	6859	7	and	and	CC
cord-015021-pol2qm74	6859	8	AT	AT	NNP
cord-015021-pol2qm74	6859	9	was	be	VBD
cord-015021-pol2qm74	6859	10	0	0	CD
cord-015021-pol2qm74	6859	11	.	.	.
cord-015021-pol2qm74	6860	1	16	16	CD
cord-015021-pol2qm74	6860	2	-	-	SYM
cord-015021-pol2qm74	6860	3	0.51	0.51	CD
cord-015021-pol2qm74	6860	4	units	unit	NNS
cord-015021-pol2qm74	6860	5	/	/	SYM
cord-015021-pol2qm74	6860	6	ml	ml	XX
cord-015021-pol2qm74	6861	1	(	(	-LRB-
cord-015021-pol2qm74	6861	2	ref	ref	NN
cord-015021-pol2qm74	6861	3	:	:	:
cord-015021-pol2qm74	6862	1	O.80	o.80	LS
cord-015021-pol2qm74	6862	2	-	-	HYPH
cord-015021-pol2qm74	6862	3	1.20	1.20	CD
cord-015021-pol2qm74	6862	4	)	)	-RRB-
cord-015021-pol2qm74	6862	5	.	.	.
cord-015021-pol2qm74	6863	1	The	the	DT
cord-015021-pol2qm74	6863	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	6863	3	concentrations	concentration	NNS
cord-015021-pol2qm74	6863	4	in	in	IN
cord-015021-pol2qm74	6863	5	retrieved	retrieve	VBN
cord-015021-pol2qm74	6863	6	blood	blood	NN
cord-015021-pol2qm74	6863	7	was	be	VBD
cord-015021-pol2qm74	6863	8	>	>	NFP
cord-015021-pol2qm74	6863	9	1000	1000	CD
cord-015021-pol2qm74	6863	10	pg	pg	NN
cord-015021-pol2qm74	6863	11	/	/	SYM
cord-015021-pol2qm74	6863	12	ml	ml	XX
cord-015021-pol2qm74	6863	13	in	in	IN
cord-015021-pol2qm74	6863	14	all	all	DT
cord-015021-pol2qm74	6863	15	samples	sample	NNS
cord-015021-pol2qm74	6863	16	.	.	.
cord-015021-pol2qm74	6864	1	TN	TN	NNP
cord-015021-pol2qm74	6864	2	v	v	NN
cord-015021-pol2qm74	6864	3	or	or	CC
cord-015021-pol2qm74	6864	4	IL	IL	NNP
cord-015021-pol2qm74	6864	5	-	-	:
cord-015021-pol2qm74	6864	6	I	-PRON-	PRP
cord-015021-pol2qm74	6864	7	was	be	VBD
cord-015021-pol2qm74	6864	8	not	not	RB
cord-015021-pol2qm74	6864	9	detectable	detectable	JJ
cord-015021-pol2qm74	6864	10	.	.	.
cord-015021-pol2qm74	6865	1	In	in	IN
cord-015021-pol2qm74	6865	2	the	the	DT
cord-015021-pol2qm74	6865	3	separate	separate	JJ
cord-015021-pol2qm74	6865	4	study	study	NN
cord-015021-pol2qm74	6865	5	,	,	,
cord-015021-pol2qm74	6865	6	(	(	-LRB-
cord-015021-pol2qm74	6865	7	n=5	n=5	NNP
cord-015021-pol2qm74	6865	8	)	)	-RRB-
cord-015021-pol2qm74	6865	9	,	,	,
cord-015021-pol2qm74	6865	10	characterlzing	characterlze	VBG
cord-015021-pol2qm74	6865	11	eytokine	eytokine	JJ
cord-015021-pol2qm74	6865	12	content	content	NN
cord-015021-pol2qm74	6865	13	in	in	IN
cord-015021-pol2qm74	6865	14	the	the	DT
cord-015021-pol2qm74	6865	15	initial	initial	JJ
cord-015021-pol2qm74	6865	16	portiere	portiere	NN
cord-015021-pol2qm74	6865	17	of	of	IN
cord-015021-pol2qm74	6865	18	drainage	drainage	NN
cord-015021-pol2qm74	6865	19	blood	blood	NN
cord-015021-pol2qm74	6865	20	,	,	,
cord-015021-pol2qm74	6865	21	IN=	IN=	''
cord-015021-pol2qm74	6866	1	(	(	-LRB-
cord-015021-pol2qm74	6866	2	range	range	NN
cord-015021-pol2qm74	6866	3	:	:	:
cord-015021-pol2qm74	6866	4	11	11	CD
cord-015021-pol2qm74	6866	5	-	-	SYM
cord-015021-pol2qm74	6866	6	277	277	CD
cord-015021-pol2qm74	6866	7	pg	pg	NN
cord-015021-pol2qm74	6866	8	/	/	SYM
cord-015021-pol2qm74	6866	9	ml	ml	NN
cord-015021-pol2qm74	6866	10	)	)	-RRB-
cord-015021-pol2qm74	6866	11	and	and	CC
cord-015021-pol2qm74	6866	12	IL	IL	NNP
cord-015021-pol2qm74	6866	13	-	-	:
cord-015021-pol2qm74	6866	14	I	I	NNP
cord-015021-pol2qm74	6867	1	(	(	-LRB-
cord-015021-pol2qm74	6867	2	range:5	range:5	NN
cord-015021-pol2qm74	6867	3	-	-	HYPH
cord-015021-pol2qm74	6867	4	125	125	CD
cord-015021-pol2qm74	6867	5	pg	pg	NN
cord-015021-pol2qm74	6867	6	/	/	SYM
cord-015021-pol2qm74	6867	7	ml	ml	NN
cord-015021-pol2qm74	6867	8	)	)	-RRB-
cord-015021-pol2qm74	6868	1	~re	~re	NN
cord-015021-pol2qm74	6868	2	present	present	JJ
cord-015021-pol2qm74	6868	3	in	in	IN
cord-015021-pol2qm74	6868	4	all	all	DT
cord-015021-pol2qm74	6868	5	samples	sample	NNS
cord-015021-pol2qm74	6869	1	but	but	CC
cord-015021-pol2qm74	6869	2	II-6	II-6	NNP
cord-015021-pol2qm74	6869	3	(	(	-LRB-
cord-015021-pol2qm74	6869	4	range	range	NN
cord-015021-pol2qm74	6869	5	:	:	:
cord-015021-pol2qm74	6869	6	O-25	O-25	NNP
cord-015021-pol2qm74	6869	7	pg	pg	NNP
cord-015021-pol2qm74	6869	8	/	/	SYM
cord-015021-pol2qm74	6869	9	ml	ml	NN
cord-015021-pol2qm74	6869	10	)	)	-RRB-
cord-015021-pol2qm74	6869	11	was	be	VBD
cord-015021-pol2qm74	6869	12	detectable	detectable	JJ
cord-015021-pol2qm74	6869	13	in	in	IN
cord-015021-pol2qm74	6869	14	o.qly	o.qly	VBG
cord-015021-pol2qm74	6869	15	one	one	CD
cord-015021-pol2qm74	6869	16	semple	semple	NNP
cord-015021-pol2qm74	6869	17	.	.	.
cord-015021-pol2qm74	6870	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	6870	2	:	:	:
cord-015021-pol2qm74	6871	1	These	these	DT
cord-015021-pol2qm74	6871	2	s	s	POS
cord-015021-pol2qm74	6871	3	findings	finding	NNS
cord-015021-pol2qm74	6871	4	indicate	indicate	VBP
cord-015021-pol2qm74	6871	5	that	that	IN
cord-015021-pol2qm74	6871	6	hypereoagulability	hypereoagulability	NN
cord-015021-pol2qm74	6871	7	and	and	CC
cord-015021-pol2qm74	6871	8	hic~	hic~	NNP
cord-015021-pol2qm74	6871	9	ccrcentratioos	ccrcentratioo	NNS
cord-015021-pol2qm74	6871	10	are	be	VBP
cord-015021-pol2qm74	6871	11	present	present	JJ
cord-015021-pol2qm74	6871	12	in	in	IN
cord-015021-pol2qm74	6871	13	retrieved	retrieve	VBN
cord-015021-pol2qm74	6871	14	blood	blood	NN
cord-015021-pol2qm74	6871	15	.	.	.
cord-015021-pol2qm74	6872	1	The	the	DT
cord-015021-pol2qm74	6872	2	cytokine	cytokine	NN
cord-015021-pol2qm74	6872	3	pattern	pattern	NN
cord-015021-pol2qm74	6872	4	in	in	IN
cord-015021-pol2qm74	6872	5	the	the	DT
cord-015021-pol2qm74	6872	6	initial	initial	JJ
cord-015021-pol2qm74	6872	7	portion	portion	NN
cord-015021-pol2qm74	6872	8	of	of	IN
cord-015021-pol2qm74	6872	9	blood	blood	NN
cord-015021-pol2qm74	6872	10	from	from	IN
cord-015021-pol2qm74	6872	11	a	a	DT
cord-015021-pol2qm74	6872	12	surgical	surgical	JJ
cord-015021-pol2qm74	6872	13	area	area	NN
cord-015021-pol2qm74	6872	14	differed	differ	VBD
cord-015021-pol2qm74	6872	15	from	from	IN
cord-015021-pol2qm74	6872	16	these	these	DT
cord-015021-pol2qm74	6872	17	observed	observe	VBN
cord-015021-pol2qm74	6872	18	in	in	IN
cord-015021-pol2qm74	6872	19	retrieved	retrieve	VBN
cord-015021-pol2qm74	6872	20	blood	blood	NN
cord-015021-pol2qm74	6872	21	and	and	CC
cord-015021-pol2qm74	6872	22	in	in	IN
cord-015021-pol2qm74	6872	23	the	the	DT
cord-015021-pol2qm74	6872	24	systemic	systemic	JJ
cord-015021-pol2qm74	6872	25	circulation	circulation	NN
cord-015021-pol2qm74	6872	26	.	.	.
cord-015021-pol2qm74	6873	1	To	to	TO
cord-015021-pol2qm74	6873	2	identify	identify	VB
cord-015021-pol2qm74	6873	3	the	the	DT
cord-015021-pol2qm74	6873	4	role	role	NN
cord-015021-pol2qm74	6873	5	of	of	IN
cord-015021-pol2qm74	6873	6	both	both	DT
cord-015021-pol2qm74	6873	7	autOlogous	autologous	JJ
cord-015021-pol2qm74	6873	8	and	and	CC
cord-015021-pol2qm74	6873	9	homologous	homologous	JJ
cord-015021-pol2qm74	6873	10	blood	blood	NN
cord-015021-pol2qm74	6873	11	on	on	IN
cord-015021-pol2qm74	6873	12	postoperative	postoperative	JJ
cord-015021-pol2qm74	6873	13	infections	infection	NNS
cord-015021-pol2qm74	6873	14	in	in	IN
cord-015021-pol2qm74	6873	15	elective	elective	JJ
cord-015021-pol2qm74	6873	16	cancer	cancer	NN
cord-015021-pol2qm74	6873	17	surgery	surgery	NN
cord-015021-pol2qm74	6873	18	.	.	.
cord-015021-pol2qm74	6874	1	Materials	material	NNS
cord-015021-pol2qm74	6874	2	and	and	CC
cord-015021-pol2qm74	6874	3	methods	method	NNS
cord-015021-pol2qm74	6874	4	:	:	:
cord-015021-pol2qm74	6874	5	159	159	CD
cord-015021-pol2qm74	6874	6	patients	patient	NNS
cord-015021-pol2qm74	6874	7	with	with	IN
cord-015021-pol2qm74	6874	8	colo	colo	JJ
cord-015021-pol2qm74	6874	9	-	-	HYPH
cord-015021-pol2qm74	6874	10	rectal	rectal	JJ
cord-015021-pol2qm74	6874	11	cancer	cancer	NN
cord-015021-pol2qm74	6874	12	submitted	submit	VBN
cord-015021-pol2qm74	6874	13	to	to	IN
cord-015021-pol2qm74	6874	14	curative	curative	JJ
cord-015021-pol2qm74	6874	15	elective	elective	JJ
cord-015021-pol2qm74	6874	16	surgery	surgery	NN
cord-015021-pol2qm74	6874	17	were	be	VBD
cord-015021-pol2qm74	6874	18	prospectively	prospectively	RB
cord-015021-pol2qm74	6874	19	studied	study	VBN
cord-015021-pol2qm74	6874	20	.	.	.
cord-015021-pol2qm74	6875	1	On	on	IN
cord-015021-pol2qm74	6875	2	hospital	hospital	NN
cord-015021-pol2qm74	6875	3	admission	admission	NN
cord-015021-pol2qm74	6875	4	the	the	DT
cord-015021-pol2qm74	6875	5	following	follow	VBG
cord-015021-pol2qm74	6875	6	nutritional	nutritional	JJ
cord-015021-pol2qm74	6875	7	measurements	measurement	NNS
cord-015021-pol2qm74	6875	8	were	be	VBD
cord-015021-pol2qm74	6875	9	assessed	assess	VBN
cord-015021-pol2qm74	6875	10	:	:	:
cord-015021-pol2qm74	6875	11	serum	serum	NN
cord-015021-pol2qm74	6875	12	level	level	NN
cord-015021-pol2qm74	6875	13	of	of	IN
cord-015021-pol2qm74	6875	14	albumin	albumin	NN
cord-015021-pol2qm74	6875	15	,	,	,
cord-015021-pol2qm74	6875	16	cholinesterase	cholinesterase	NN
cord-015021-pol2qm74	6875	17	,	,	,
cord-015021-pol2qm74	6875	18	delayed	delay	VBN
cord-015021-pol2qm74	6875	19	hypersensivity	hypersensivity	NN
cord-015021-pol2qm74	6875	20	response	response	NN
cord-015021-pol2qm74	6875	21	,	,	,
cord-015021-pol2qm74	6875	22	total	total	JJ
cord-015021-pol2qm74	6875	23	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	6875	24	count	count	NN
cord-015021-pol2qm74	6875	25	and	and	CC
cord-015021-pol2qm74	6875	26	weight	weight	NN
cord-015021-pol2qm74	6875	27	loss	loss	NN
cord-015021-pol2qm74	6875	28	,	,	,
cord-015021-pol2qm74	6875	29	as	as	IN
cord-015021-pol2qm74	6875	30	were	be	VBD
cord-015021-pol2qm74	6875	31	age	age	NN
cord-015021-pol2qm74	6875	32	and	and	CC
cord-015021-pol2qm74	6875	33	sex	sex	NN
cord-015021-pol2qm74	6875	34	,	,	,
cord-015021-pol2qm74	6875	35	Duration	duration	NN
cord-015021-pol2qm74	6875	36	of	of	IN
cord-015021-pol2qm74	6875	37	operation	operation	NN
cord-015021-pol2qm74	6875	38	,	,	,
cord-015021-pol2qm74	6875	39	operative	operative	JJ
cord-015021-pol2qm74	6875	40	blood	blood	NN
cord-015021-pol2qm74	6875	41	loss	loss	NN
cord-015021-pol2qm74	6875	42	,	,	,
cord-015021-pol2qm74	6875	43	amount	amount	NN
cord-015021-pol2qm74	6875	44	and	and	CC
cord-015021-pol2qm74	6875	45	type	type	NN
cord-015021-pol2qm74	6875	46	of	of	IN
cord-015021-pol2qm74	6875	47	blood	blood	NN
cord-015021-pol2qm74	6875	48	given	give	VBN
cord-015021-pol2qm74	6875	49	,	,	,
cord-015021-pol2qm74	6875	50	pathological	pathological	JJ
cord-015021-pol2qm74	6875	51	Dukes	duke	NNS
cord-015021-pol2qm74	6875	52	'	'	POS
cord-015021-pol2qm74	6875	53	stage	stage	NN
cord-015021-pol2qm74	6875	54	of	of	IN
cord-015021-pol2qm74	6875	55	the	the	DT
cord-015021-pol2qm74	6875	56	disease	disease	NN
cord-015021-pol2qm74	6875	57	and	and	CC
cord-015021-pol2qm74	6875	58	the	the	DT
cord-015021-pol2qm74	6875	59	attending	attend	VBG
cord-015021-pol2qm74	6875	60	surgeon	surgeon	NN
cord-015021-pol2qm74	6875	61	were	be	VBD
cord-015021-pol2qm74	6875	62	also	also	RB
cord-015021-pol2qm74	6875	63	recorded	record	VBN
cord-015021-pol2qm74	6875	64	.	.	.
cord-015021-pol2qm74	6876	1	Results	result	NNS
cord-015021-pol2qm74	6876	2	:	:	:
cord-015021-pol2qm74	6877	1	Eighty	eighty	CD
cord-015021-pol2qm74	6877	2	-	-	HYPH
cord-015021-pol2qm74	6877	3	four	four	CD
cord-015021-pol2qm74	6877	4	patients	patient	NNS
cord-015021-pol2qm74	6877	5	(	(	-LRB-
cord-015021-pol2qm74	6877	6	52.8	52.8	CD
cord-015021-pol2qm74	6877	7	%	%	NN
cord-015021-pol2qm74	6877	8	)	)	-RRB-
cord-015021-pol2qm74	6877	9	were	be	VBD
cord-015021-pol2qm74	6877	10	perioperatively	perioperatively	RB
cord-015021-pol2qm74	6877	11	transfused	transfuse	VBN
cord-015021-pol2qm74	6877	12	.	.	.
cord-015021-pol2qm74	6878	1	Thirty	thirty	CD
cord-015021-pol2qm74	6878	2	-	-	HYPH
cord-015021-pol2qm74	6878	3	six	six	CD
cord-015021-pol2qm74	6878	4	(	(	-LRB-
cord-015021-pol2qm74	6878	5	42.8	42.8	CD
cord-015021-pol2qm74	6878	6	%	%	NN
cord-015021-pol2qm74	6878	7	)	)	-RRB-
cord-015021-pol2qm74	6878	8	patients	patient	NNS
cord-015021-pol2qm74	6878	9	were	be	VBD
cord-015021-pol2qm74	6878	10	given	give	VBN
cord-015021-pol2qm74	6878	11	autologous	autologous	JJ
cord-015021-pol2qm74	6878	12	blood	blood	NN
cord-015021-pol2qm74	6878	13	,	,	,
cord-015021-pol2qm74	6878	14	while	while	IN
cord-015021-pol2qm74	6878	15	48	48	CD
cord-015021-pol2qm74	6878	16	(	(	-LRB-
cord-015021-pol2qm74	6878	17	57.2	57.2	CD
cord-015021-pol2qm74	6878	18	%	%	NN
cord-015021-pol2qm74	6878	19	)	)	-RRB-
cord-015021-pol2qm74	6878	20	received	receive	VBD
cord-015021-pol2qm74	6878	21	homologous	homologous	JJ
cord-015021-pol2qm74	6878	22	blood	blood	NN
cord-015021-pol2qm74	6878	23	.	.	.
cord-015021-pol2qm74	6879	1	No	no	DT
cord-015021-pol2qm74	6879	2	patients	patient	NNS
cord-015021-pol2qm74	6879	3	received	receive	VBD
cord-015021-pol2qm74	6879	4	both	both	CC
cord-015021-pol2qm74	6879	5	autologous	autologous	JJ
cord-015021-pol2qm74	6879	6	and	and	CC
cord-015021-pol2qm74	6879	7	homologous	homologous	JJ
cord-015021-pol2qm74	6879	8	blood	blood	NN
cord-015021-pol2qm74	6879	9	.	.	.
cord-015021-pol2qm74	6880	1	Twenty	twenty	CD
cord-015021-pol2qm74	6880	2	eight	eight	CD
cord-015021-pol2qm74	6880	3	(	(	-LRB-
cord-015021-pol2qm74	6880	4	17.9	17.9	CD
cord-015021-pol2qm74	6880	5	%	%	NN
cord-015021-pol2qm74	6880	6	)	)	-RRB-
cord-015021-pol2qm74	6880	7	patients	patient	NNS
cord-015021-pol2qm74	6880	8	developed	develop	VBD
cord-015021-pol2qm74	6880	9	postoperative	postoperative	JJ
cord-015021-pol2qm74	6880	10	infections	infection	NNS
cord-015021-pol2qm74	6880	11	.	.	.
cord-015021-pol2qm74	6881	1	Non	non	JJ
cord-015021-pol2qm74	6881	2	transfused	transfuse	VBN
cord-015021-pol2qm74	6881	3	patients	patient	NNS
cord-015021-pol2qm74	6881	4	had	have	VBD
cord-015021-pol2qm74	6881	5	a	a	DT
cord-015021-pol2qm74	6881	6	9.3	9.3	CD
cord-015021-pol2qm74	6881	7	%	%	NN
cord-015021-pol2qm74	6881	8	infection	infection	NN
cord-015021-pol2qm74	6881	9	rate	rate	NN
cord-015021-pol2qm74	6881	10	,	,	,
cord-015021-pol2qm74	6881	11	those	those	DT
cord-015021-pol2qm74	6881	12	receiving	receive	VBG
cord-015021-pol2qm74	6881	13	autologous	autologous	JJ
cord-015021-pol2qm74	6881	14	blood	blood	NN
cord-015021-pol2qm74	6881	15	had	have	VBD
cord-015021-pol2qm74	6881	16	a	a	DT
cord-015021-pol2qm74	6881	17	13.9	13.9	CD
cord-015021-pol2qm74	6881	18	%	%	NN
cord-015021-pol2qm74	6881	19	infection	infection	NN
cord-015021-pol2qm74	6881	20	rate	rate	NN
cord-015021-pol2qm74	6881	21	,	,	,
cord-015021-pol2qm74	6881	22	whi]e	whi]e	NNP
cord-015021-pol2qm74	6881	23	in	in	IN
cord-015021-pol2qm74	6881	24	the	the	DT
cord-015021-pol2qm74	6881	25	homologous	homologous	JJ
cord-015021-pol2qm74	6881	26	blood	blood	NN
cord-015021-pol2qm74	6881	27	group	group	NN
cord-015021-pol2qm74	6881	28	the	the	DT
cord-015021-pol2qm74	6881	29	infection	infection	NN
cord-015021-pol2qm74	6881	30	rate	rate	NN
cord-015021-pol2qm74	6881	31	was	be	VBD
cord-015021-pol2qm74	6881	32	33.3	33.3	CD
cord-015021-pol2qm74	6881	33	%	%	NN
cord-015021-pol2qm74	6881	34	(	(	-LRB-
cord-015021-pol2qm74	6881	35	p	p	NN
cord-015021-pol2qm74	6881	36	<	<	XX
cord-015021-pol2qm74	6881	37	0.001	0.001	CD
cord-015021-pol2qm74	6881	38	)	)	-RRB-
cord-015021-pol2qm74	6881	39	.	.	.
cord-015021-pol2qm74	6882	1	Univariate	Univariate	NNP
cord-015021-pol2qm74	6882	2	analysis	analysis	NN
cord-015021-pol2qm74	6882	3	showed	show	VBD
cord-015021-pol2qm74	6882	4	that	that	IN
cord-015021-pol2qm74	6882	5	infections	infection	NNS
cord-015021-pol2qm74	6882	6	were	be	VBD
cord-015021-pol2qm74	6882	7	significantly	significantly	RB
cord-015021-pol2qm74	6882	8	related	relate	VBN
cord-015021-pol2qm74	6882	9	to	to	IN
cord-015021-pol2qm74	6882	10	operative	operative	JJ
cord-015021-pol2qm74	6882	11	blood	blood	NN
cord-015021-pol2qm74	6882	12	loss	loss	NN
cord-015021-pol2qm74	6882	13	(	(	-LRB-
cord-015021-pol2qm74	6882	14	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	6882	15	)	)	-RRB-
cord-015021-pol2qm74	6882	16	,	,	,
cord-015021-pol2qm74	6882	17	length	length	NN
cord-015021-pol2qm74	6882	18	of	of	IN
cord-015021-pol2qm74	6882	19	operation	operation	NN
cord-015021-pol2qm74	6882	20	(	(	-LRB-
cord-015021-pol2qm74	6882	21	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6882	22	)	)	-RRB-
cord-015021-pol2qm74	6883	1	blood	blood	NN
cord-015021-pol2qm74	6883	2	transfusion	transfusion	NN
cord-015021-pol2qm74	6883	3	(	(	-LRB-
cord-015021-pol2qm74	6883	4	p<0.05	p<0.05	CD
cord-015021-pol2qm74	6883	5	)	)	-RRB-
cord-015021-pol2qm74	6883	6	and	and	CC
cord-015021-pol2qm74	6883	7	attending	attend	VBG
cord-015021-pol2qm74	6883	8	surgeon	surgeon	NN
cord-015021-pol2qm74	6883	9	(	(	-LRB-
cord-015021-pol2qm74	6883	10	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	6883	11	)	)	-RRB-
cord-015021-pol2qm74	6883	12	.	.	.
cord-015021-pol2qm74	6884	1	Multivariate	multivariate	JJ
cord-015021-pol2qm74	6884	2	analysis	analysis	NN
cord-015021-pol2qm74	6884	3	identified	identify	VBD
cord-015021-pol2qm74	6884	4	homologous	homologous	JJ
cord-015021-pol2qm74	6884	5	blood	blood	NN
cord-015021-pol2qm74	6884	6	transfusion	transfusion	NN
cord-015021-pol2qm74	6884	7	as	as	IN
cord-015021-pol2qm74	6884	8	the	the	DT
cord-015021-pol2qm74	6884	9	only	only	JJ
cord-015021-pol2qm74	6884	10	variable	variable	NN
cord-015021-pol2qm74	6884	11	related	relate	VBN
cord-015021-pol2qm74	6884	12	to	to	IN
cord-015021-pol2qm74	6884	13	the	the	DT
cord-015021-pol2qm74	6884	14	occurrence	occurrence	NN
cord-015021-pol2qm74	6884	15	of	of	IN
cord-015021-pol2qm74	6884	16	postoperative	postoperative	JJ
cord-015021-pol2qm74	6884	17	infections	infection	NNS
cord-015021-pol2qm74	6884	18	,	,	,
cord-015021-pol2qm74	6884	19	while	while	IN
cord-015021-pol2qm74	6884	20	the	the	DT
cord-015021-pol2qm74	6884	21	other	other	JJ
cord-015021-pol2qm74	6884	22	variables	variable	NNS
cord-015021-pol2qm74	6884	23	failed	fail	VBD
cord-015021-pol2qm74	6884	24	to	to	TO
cord-015021-pol2qm74	6884	25	reach	reach	VB
cord-015021-pol2qm74	6884	26	statistical	statistical	JJ
cord-015021-pol2qm74	6884	27	significance	significance	NN
cord-015021-pol2qm74	6884	28	.	.	.
cord-015021-pol2qm74	6885	1	Blood	blood	NN
cord-015021-pol2qm74	6885	2	transfusion	transfusion	NN
cord-015021-pol2qm74	6885	3	(	(	-LRB-
cord-015021-pol2qm74	6885	4	BT	BT	NNP
cord-015021-pol2qm74	6885	5	)	)	-RRB-
cord-015021-pol2qm74	6885	6	remains	remain	VBZ
cord-015021-pol2qm74	6885	7	an	an	DT
cord-015021-pol2qm74	6885	8	essential	essential	JJ
cord-015021-pol2qm74	6885	9	life	life	NN
cord-015021-pol2qm74	6885	10	-	-	HYPH
cord-015021-pol2qm74	6885	11	saving	save	VBG
cord-015021-pol2qm74	6885	12	treatment	treatment	NN
cord-015021-pol2qm74	6885	13	for	for	IN
cord-015021-pol2qm74	6885	14	surgical	surgical	JJ
cord-015021-pol2qm74	6885	15	patients	patient	NNS
cord-015021-pol2qm74	6885	16	.	.	.
cord-015021-pol2qm74	6886	1	However	however	RB
cord-015021-pol2qm74	6886	2	,	,	,
cord-015021-pol2qm74	6886	3	besides	besides	IN
cord-015021-pol2qm74	6886	4	the	the	DT
cord-015021-pol2qm74	6886	5	beneficial	beneficial	JJ
cord-015021-pol2qm74	6886	6	short	short	JJ
cord-015021-pol2qm74	6886	7	-	-	HYPH
cord-015021-pol2qm74	6886	8	term	term	NN
cord-015021-pol2qm74	6886	9	impacts	impact	NNS
cord-015021-pol2qm74	6886	10	,	,	,
cord-015021-pol2qm74	6886	11	negative	negative	JJ
cord-015021-pol2qm74	6886	12	longer	long	JJR
cord-015021-pol2qm74	6886	13	-	-	HYPH
cord-015021-pol2qm74	6886	14	term	term	NN
cord-015021-pol2qm74	6886	15	effects	effect	NNS
cord-015021-pol2qm74	6886	16	are	be	VBP
cord-015021-pol2qm74	6886	17	observed	observe	VBN
cord-015021-pol2qm74	6886	18	,	,	,
cord-015021-pol2qm74	6886	19	which	which	WDT
cord-015021-pol2qm74	6886	20	include	include	VBP
cord-015021-pol2qm74	6886	21	various	various	JJ
cord-015021-pol2qm74	6886	22	alterations	alteration	NNS
cord-015021-pol2qm74	6886	23	in	in	IN
cord-015021-pol2qm74	6886	24	the	the	DT
cord-015021-pol2qm74	6886	25	immune	immune	JJ
cord-015021-pol2qm74	6886	26	responsiveness	responsiveness	NN
cord-015021-pol2qm74	6886	27	.	.	.
cord-015021-pol2qm74	6887	1	In	in	IN
cord-015021-pol2qm74	6887	2	surgical	surgical	JJ
cord-015021-pol2qm74	6887	3	patients	patient	NNS
cord-015021-pol2qm74	6887	4	these	these	DT
cord-015021-pol2qm74	6887	5	alterations	alteration	NNS
cord-015021-pol2qm74	6887	6	may	may	MD
cord-015021-pol2qm74	6887	7	contribute	contribute	VB
cord-015021-pol2qm74	6887	8	to	to	IN
cord-015021-pol2qm74	6887	9	the	the	DT
cord-015021-pol2qm74	6887	10	increased	increase	VBN
cord-015021-pol2qm74	6887	11	risk	risk	NN
cord-015021-pol2qm74	6887	12	for	for	IN
cord-015021-pol2qm74	6887	13	infections	infection	NNS
cord-015021-pol2qm74	6887	14	and	and	CC
cord-015021-pol2qm74	6887	15	cancer	cancer	NN
cord-015021-pol2qm74	6887	16	recurrence	recurrence	NN
cord-015021-pol2qm74	6887	17	.	.	.
cord-015021-pol2qm74	6888	1	Since	since	IN
cord-015021-pol2qm74	6888	2	relatively	relatively	RB
cord-015021-pol2qm74	6888	3	few	few	JJ
cord-015021-pol2qm74	6888	4	data	datum	NNS
cord-015021-pol2qm74	6888	5	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	6888	6	immunologic	immunologic	JJ
cord-015021-pol2qm74	6888	7	changes	change	NNS
cord-015021-pol2qm74	6888	8	occurring	occur	VBG
cord-015021-pol2qm74	6888	9	in	in	IN
cord-015021-pol2qm74	6888	10	other	other	JJ
cord-015021-pol2qm74	6888	11	lymphoid	lymphoid	JJ
cord-015021-pol2qm74	6888	12	compartments	compartment	NNS
cord-015021-pol2qm74	6888	13	than	than	IN
cord-015021-pol2qm74	6888	14	blood	blood	NN
cord-015021-pol2qm74	6888	15	after	after	IN
cord-015021-pol2qm74	6888	16	BT	BT	NNP
cord-015021-pol2qm74	6888	17	,	,	,
cord-015021-pol2qm74	6888	18	we	-PRON-	PRP
cord-015021-pol2qm74	6888	19	studied	study	VBD
cord-015021-pol2qm74	6888	20	the	the	DT
cord-015021-pol2qm74	6888	21	effect	effect	NN
cord-015021-pol2qm74	6888	22	of	of	IN
cord-015021-pol2qm74	6888	23	ET	ET	NNP
cord-015021-pol2qm74	6888	24	on	on	IN
cord-015021-pol2qm74	6888	25	the	the	DT
cord-015021-pol2qm74	6888	26	frequency	frequency	NN
cord-015021-pol2qm74	6888	27	and	and	CC
cord-015021-pol2qm74	6888	28	responsiveness	responsiveness	NN
cord-015021-pol2qm74	6888	29	of	of	IN
cord-015021-pol2qm74	6888	30	immune	immune	JJ
cord-015021-pol2qm74	6888	31	cells	cell	NNS
cord-015021-pol2qm74	6888	32	in	in	IN
cord-015021-pol2qm74	6888	33	bone	bone	NN
cord-015021-pol2qm74	6888	34	marrow	marrow	NN
cord-015021-pol2qm74	6888	35	(	(	-LRB-
cord-015021-pol2qm74	6888	36	BM	BM	NNP
cord-015021-pol2qm74	6888	37	)	)	-RRB-
cord-015021-pol2qm74	6888	38	,	,	,
cord-015021-pol2qm74	6888	39	spleen	spleen	NNS
cord-015021-pol2qm74	6888	40	(	(	-LRB-
cord-015021-pol2qm74	6888	41	SPL	SPL	NNP
cord-015021-pol2qm74	6888	42	)	)	-RRB-
cord-015021-pol2qm74	6888	43	and	and	CC
cord-015021-pol2qm74	6888	44	blood	blood	NN
cord-015021-pol2qm74	6888	45	(	(	-LRB-
cord-015021-pol2qm74	6888	46	B	b	NN
cord-015021-pol2qm74	6888	47	)	)	-RRB-
cord-015021-pol2qm74	6888	48	in	in	IN
cord-015021-pol2qm74	6888	49	a	a	DT
cord-015021-pol2qm74	6888	50	rat	rat	NN
cord-015021-pol2qm74	6888	51	model	model	NN
cord-015021-pol2qm74	6888	52	.	.	.
cord-015021-pol2qm74	6889	1	Normovalemic	Normovalemic	NNP
cord-015021-pol2qm74	6889	2	,	,	,
cord-015021-pol2qm74	6889	3	2	2	CD
cord-015021-pol2qm74	6889	4	month	month	NN
cord-015021-pol2qm74	6889	5	old	old	JJ
cord-015021-pol2qm74	6889	6	rats	rat	NNS
cord-015021-pol2qm74	6889	7	were	be	VBD
cord-015021-pol2qm74	6889	8	transfused	transfuse	VBN
cord-015021-pol2qm74	6889	9	intravenously	intravenously	RB
cord-015021-pol2qm74	6889	10	with	with	IN
cord-015021-pol2qm74	6889	11	syngeneic	syngeneic	NNS
cord-015021-pol2qm74	6889	12	heparinized	heparinized	NNP
cord-015021-pol2qm74	6889	13	venous	venous	JJ
cord-015021-pol2qm74	6889	14	blood	blood	NN
cord-015021-pol2qm74	6889	15	(	(	-LRB-
cord-015021-pol2qm74	6889	16	3x2ml	3x2ml	CD
cord-015021-pol2qm74	6889	17	,	,	,
cord-015021-pol2qm74	6889	18	every	every	DT
cord-015021-pol2qm74	6889	19	other	other	JJ
cord-015021-pol2qm74	6889	20	day	day	NN
cord-015021-pol2qm74	6889	21	)	)	-RRB-
cord-015021-pol2qm74	6889	22	,	,	,
cord-015021-pol2qm74	6889	23	and	and	CC
cord-015021-pol2qm74	6889	24	3	3	CD
cord-015021-pol2qm74	6889	25	,	,	,
cord-015021-pol2qm74	6889	26	7	7	CD
cord-015021-pol2qm74	6889	27	and	and	CC
cord-015021-pol2qm74	6889	28	14	14	CD
cord-015021-pol2qm74	6889	29	days	day	NNS
cord-015021-pol2qm74	6889	30	after	after	IN
cord-015021-pol2qm74	6889	31	the	the	DT
cord-015021-pol2qm74	6889	32	last	last	JJ
cord-015021-pol2qm74	6889	33	transfusion	transfusion	NN
cord-015021-pol2qm74	6889	34	BM	bm	NN
cord-015021-pol2qm74	6889	35	cells	cell	NNS
cord-015021-pol2qm74	6889	36	(	(	-LRB-
cord-015021-pol2qm74	6889	37	LEH	LEH	NNP
cord-015021-pol2qm74	6889	38	is	be	VBZ
cord-015021-pol2qm74	6889	39	an	an	DT
cord-015021-pol2qm74	6889	40	experimental	experimental	JJ
cord-015021-pol2qm74	6889	41	oxygen	oxygen	NN
cord-015021-pol2qm74	6889	42	-	-	HYPH
cord-015021-pol2qm74	6889	43	carrying	carry	VBG
cord-015021-pol2qm74	6889	44	resuscitation	resuscitation	NN
cord-015021-pol2qm74	6889	45	fluid	fluid	NN
cord-015021-pol2qm74	6889	46	.	.	.
cord-015021-pol2qm74	6890	1	Since	since	IN
cord-015021-pol2qm74	6890	2	LEH	LEH	NNP
cord-015021-pol2qm74	6890	3	is	be	VBZ
cord-015021-pol2qm74	6890	4	cleared	clear	VBN
cord-015021-pol2qm74	6890	5	from	from	IN
cord-015021-pol2qm74	6890	6	the	the	DT
cord-015021-pol2qm74	6890	7	circulation	circulation	NN
cord-015021-pol2qm74	6890	8	primarily	primarily	RB
cord-015021-pol2qm74	6890	9	by	by	IN
cord-015021-pol2qm74	6890	10	the	the	DT
cord-015021-pol2qm74	6890	11	MPS	MPS	NNP
cord-015021-pol2qm74	6890	12	,	,	,
cord-015021-pol2qm74	6890	13	its	-PRON-	PRP$
cord-015021-pol2qm74	6890	14	effect	effect	NN
cord-015021-pol2qm74	6890	15	on	on	IN
cord-015021-pol2qm74	6890	16	the	the	DT
cord-015021-pol2qm74	6890	17	development	development	NN
cord-015021-pol2qm74	6890	18	of	of	IN
cord-015021-pol2qm74	6890	19	sepsis	sepsis	NN
cord-015021-pol2qm74	6890	20	and	and	CC
cord-015021-pol2qm74	6890	21	the	the	DT
cord-015021-pol2qm74	6890	22	nature	nature	NN
cord-015021-pol2qm74	6890	23	of	of	IN
cord-015021-pol2qm74	6890	24	its	-PRON-	PRP$
cord-015021-pol2qm74	6890	25	relationship	relationship	NN
cord-015021-pol2qm74	6890	26	with	with	IN
cord-015021-pol2qm74	6890	27	the	the	DT
cord-015021-pol2qm74	6890	28	MPS	MPS	NNP
cord-015021-pol2qm74	6890	29	remain	remain	VBP
cord-015021-pol2qm74	6890	30	a	a	DT
cord-015021-pol2qm74	6890	31	major	major	JJ
cord-015021-pol2qm74	6890	32	concern	concern	NN
cord-015021-pol2qm74	6890	33	.	.	.
cord-015021-pol2qm74	6891	1	Preliminary	preliminary	JJ
cord-015021-pol2qm74	6891	2	in	in	IN
cord-015021-pol2qm74	6891	3	vivo	vivo	NNP
cord-015021-pol2qm74	6891	4	data	datum	NNS
cord-015021-pol2qm74	6891	5	from	from	IN
cord-015021-pol2qm74	6891	6	our	-PRON-	PRP$
cord-015021-pol2qm74	6891	7	laboratory	laboratory	NN
cord-015021-pol2qm74	6891	8	failed	fail	VBD
cord-015021-pol2qm74	6891	9	to	to	TO
cord-015021-pol2qm74	6891	10	show	show	VB
cord-015021-pol2qm74	6891	11	any	any	DT
cord-015021-pol2qm74	6891	12	LEH	LEH	NNP
cord-015021-pol2qm74	6891	13	effect	effect	NN
cord-015021-pol2qm74	6891	14	on	on	IN
cord-015021-pol2qm74	6891	15	the	the	DT
cord-015021-pol2qm74	6891	16	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	6891	17	and	and	CC
cord-015021-pol2qm74	6891	18	hematologic	hematologic	JJ
cord-015021-pol2qm74	6891	19	responses	response	NNS
cord-015021-pol2qm74	6891	20	to	to	IN
cord-015021-pol2qm74	6891	21	endotoxin	endotoxin	VB
cord-015021-pol2qm74	6891	22	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	6891	23	(	(	-LRB-
cord-015021-pol2qm74	6891	24	LPS	LPS	NNP
cord-015021-pol2qm74	6891	25	)	)	-RRB-
cord-015021-pol2qm74	6891	26	in	in	IN
cord-015021-pol2qm74	6891	27	the	the	DT
cord-015021-pol2qm74	6891	28	rat	rat	NN
cord-015021-pol2qm74	6891	29	.	.	.
cord-015021-pol2qm74	6892	1	In	in	IN
cord-015021-pol2qm74	6892	2	contrast	contrast	NN
cord-015021-pol2qm74	6892	3	,	,	,
cord-015021-pol2qm74	6892	4	LEH	LEH	NNP
cord-015021-pol2qm74	6892	5	exacerbated	exacerbate	VBD
cord-015021-pol2qm74	6892	6	the	the	DT
cord-015021-pol2qm74	6892	7	LPS	LPS	NNP
cord-015021-pol2qm74	6892	8	-	-	HYPH
cord-015021-pol2qm74	6892	9	induced	induce	VBN
cord-015021-pol2qm74	6892	10	TNFa	TNFa	NNP
cord-015021-pol2qm74	6892	11	production	production	NN
cord-015021-pol2qm74	6892	12	and	and	CC
cord-015021-pol2qm74	6892	13	early	early	JJ
cord-015021-pol2qm74	6892	14	mortality	mortality	NN
cord-015021-pol2qm74	6892	15	.	.	.
cord-015021-pol2qm74	6893	1	The	the	DT
cord-015021-pol2qm74	6893	2	exacerbation	exacerbation	NN
cord-015021-pol2qm74	6893	3	of	of	IN
cord-015021-pol2qm74	6893	4	early	early	JJ
cord-015021-pol2qm74	6893	5	mortality	mortality	NN
cord-015021-pol2qm74	6893	6	by	by	IN
cord-015021-pol2qm74	6893	7	LEH	LEH	NNP
cord-015021-pol2qm74	6893	8	was	be	VBD
cord-015021-pol2qm74	6893	9	attenuated	attenuate	VBN
cord-015021-pol2qm74	6893	10	by	by	IN
cord-015021-pol2qm74	6893	11	pretreatment	pretreatment	NN
cord-015021-pol2qm74	6893	12	with	with	IN
cord-015021-pol2qm74	6893	13	the	the	DT
cord-015021-pol2qm74	6893	14	TNFu	TNFu	NNP
cord-015021-pol2qm74	6893	15	synthesis	synthesis	NN
cord-015021-pol2qm74	6893	16	inhibitor	inhibitor	NN
cord-015021-pol2qm74	6893	17	rolipram	rolipram	NNP
cord-015021-pol2qm74	6893	18	.	.	.
cord-015021-pol2qm74	6894	1	Ex	Ex	NNP
cord-015021-pol2qm74	6894	2	vivo	vivo	NN
cord-015021-pol2qm74	6894	3	,	,	,
cord-015021-pol2qm74	6894	4	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6894	5	macrophages	macrophage	NNS
cord-015021-pol2qm74	6894	6	from	from	IN
cord-015021-pol2qm74	6894	7	rats	rat	NNS
cord-015021-pol2qm74	6894	8	treated	treat	VBN
cord-015021-pol2qm74	6894	9	with	with	IN
cord-015021-pol2qm74	6894	10	LEH	LEH	NNP
cord-015021-pol2qm74	6894	11	and	and	CC
cord-015021-pol2qm74	6894	12	LPS	LPS	NNP
cord-015021-pol2qm74	6895	1	have	have	VBP
cord-015021-pol2qm74	6895	2	shown	show	VBN
cord-015021-pol2qm74	6895	3	increased	increase	VBN
cord-015021-pol2qm74	6895	4	IL	IL	NNP
cord-015021-pol2qm74	6895	5	-	-	HYPH
cord-015021-pol2qm74	6895	6	lg	lg	NNP
cord-015021-pol2qm74	6895	7	mRNA	mRNA	NNP
cord-015021-pol2qm74	6895	8	signal	signal	NN
cord-015021-pol2qm74	6895	9	as	as	IN
cord-015021-pol2qm74	6895	10	compared	compare	VBN
cord-015021-pol2qm74	6895	11	to	to	IN
cord-015021-pol2qm74	6895	12	LPS	LPS	NNP
cord-015021-pol2qm74	6895	13	alone	alone	RB
cord-015021-pol2qm74	6895	14	.	.	.
cord-015021-pol2qm74	6896	1	Also	also	RB
cord-015021-pol2qm74	6896	2	,	,	,
cord-015021-pol2qm74	6896	3	LEH	LEH	NNP
cord-015021-pol2qm74	6896	4	increased	increase	VBD
cord-015021-pol2qm74	6896	5	TNFtx	tnftx	DT
cord-015021-pol2qm74	6896	6	production	production	NN
cord-015021-pol2qm74	6896	7	by	by	IN
cord-015021-pol2qm74	6896	8	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6896	9	macrophages	macrophage	NNS
cord-015021-pol2qm74	6896	10	in	in	IN
cord-015021-pol2qm74	6896	11	response	response	NN
cord-015021-pol2qm74	6896	12	to	to	IN
cord-015021-pol2qm74	6896	13	LPS	LPS	NNP
cord-015021-pol2qm74	6896	14	stimulation	stimulation	NN
cord-015021-pol2qm74	6896	15	in	in	IN
cord-015021-pol2qm74	6896	16	vitro	vitro	FW
cord-015021-pol2qm74	6896	17	.	.	.
cord-015021-pol2qm74	6897	1	Additionally	additionally	RB
cord-015021-pol2qm74	6897	2	,	,	,
cord-015021-pol2qm74	6897	3	recent	recent	JJ
cord-015021-pol2qm74	6897	4	pilot	pilot	NN
cord-015021-pol2qm74	6897	5	studies	study	NNS
cord-015021-pol2qm74	6897	6	indicate	indicate	VBP
cord-015021-pol2qm74	6897	7	that	that	IN
cord-015021-pol2qm74	6897	8	LEH	LEH	NNP
cord-015021-pol2qm74	6897	9	attenuates	attenuate	VBZ
cord-015021-pol2qm74	6897	10	PMA	PMA	NNP
cord-015021-pol2qm74	6897	11	-	-	HYPH
cord-015021-pol2qm74	6897	12	induced	induce	VBN
cord-015021-pol2qm74	6897	13	superoxide	superoxide	NN
cord-015021-pol2qm74	6897	14	production	production	NN
cord-015021-pol2qm74	6897	15	from	from	IN
cord-015021-pol2qm74	6897	16	rat	rat	NN
cord-015021-pol2qm74	6897	17	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	6897	18	macrophages	macrophage	NNS
cord-015021-pol2qm74	6897	19	and	and	CC
cord-015021-pol2qm74	6897	20	that	that	IN
cord-015021-pol2qm74	6897	21	LEH	LEH	NNP
cord-015021-pol2qm74	6897	22	augments	augment	VBZ
cord-015021-pol2qm74	6897	23	fMLP	fMLP	VBN
cord-015021-pol2qm74	6897	24	-	-	HYPH
cord-015021-pol2qm74	6897	25	induced	induce	VBN
cord-015021-pol2qm74	6897	26	migration	migration	NN
cord-015021-pol2qm74	6897	27	of	of	IN
cord-015021-pol2qm74	6897	28	human	human	JJ
cord-015021-pol2qm74	6897	29	monocytes	monocyte	NNS
cord-015021-pol2qm74	6897	30	.	.	.
cord-015021-pol2qm74	6898	1	Taken	take	VBN
cord-015021-pol2qm74	6898	2	together	together	RB
cord-015021-pol2qm74	6898	3	,	,	,
cord-015021-pol2qm74	6898	4	these	these	DT
cord-015021-pol2qm74	6898	5	data	datum	NNS
cord-015021-pol2qm74	6898	6	strongly	strongly	RB
cord-015021-pol2qm74	6898	7	support	support	VBP
cord-015021-pol2qm74	6898	8	possible	possible	JJ
cord-015021-pol2qm74	6898	9	interactions	interaction	NNS
cord-015021-pol2qm74	6898	10	of	of	IN
cord-015021-pol2qm74	6898	11	LEH	LEH	NNP
cord-015021-pol2qm74	6898	12	with	with	IN
cord-015021-pol2qm74	6898	13	the	the	DT
cord-015021-pol2qm74	6898	14	MPS	MPS	NNP
cord-015021-pol2qm74	6898	15	and	and	CC
cord-015021-pol2qm74	6898	16	therefore	therefore	RB
cord-015021-pol2qm74	6898	17	the	the	DT
cord-015021-pol2qm74	6898	18	nature	nature	NN
cord-015021-pol2qm74	6898	19	of	of	IN
cord-015021-pol2qm74	6898	20	such	such	JJ
cord-015021-pol2qm74	6898	21	interactions	interaction	NNS
cord-015021-pol2qm74	6898	22	should	should	MD
cord-015021-pol2qm74	6898	23	be	be	VB
cord-015021-pol2qm74	6898	24	further	further	RB
cord-015021-pol2qm74	6898	25	explored	explore	VBN
cord-015021-pol2qm74	6898	26	.	.	.
cord-015021-pol2qm74	6899	1	Over	over	IN
cord-015021-pol2qm74	6899	2	the	the	DT
cord-015021-pol2qm74	6899	3	last	last	JJ
cord-015021-pol2qm74	6899	4	decade	decade	NN
cord-015021-pol2qm74	6899	5	,	,	,
cord-015021-pol2qm74	6899	6	we	-PRON-	PRP
cord-015021-pol2qm74	6899	7	have	have	VBP
cord-015021-pol2qm74	6899	8	developed	develop	VBN
cord-015021-pol2qm74	6899	9	liposome	liposome	NN
cord-015021-pol2qm74	6899	10	encapsulated	encapsulate	VBN
cord-015021-pol2qm74	6899	11	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6899	12	(	(	-LRB-
cord-015021-pol2qm74	6899	13	LEH	LEH	NNP
cord-015021-pol2qm74	6899	14	)	)	-RRB-
cord-015021-pol2qm74	6899	15	as	as	IN
cord-015021-pol2qm74	6899	16	an	an	DT
cord-015021-pol2qm74	6899	17	artificial	artificial	JJ
cord-015021-pol2qm74	6899	18	oxygen	oxygen	NN
cord-015021-pol2qm74	6899	19	carrying	carrying	NN
cord-015021-pol2qm74	6899	20	fluid	fluid	NN
cord-015021-pol2qm74	6899	21	,	,	,
cord-015021-pol2qm74	6899	22	or	or	CC
cord-015021-pol2qm74	6899	23	blood	blood	NN
cord-015021-pol2qm74	6899	24	substitute	substitute	NN
cord-015021-pol2qm74	6899	25	.	.	.
cord-015021-pol2qm74	6900	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	6900	2	efforts	effort	NNS
cord-015021-pol2qm74	6900	3	have	have	VBP
cord-015021-pol2qm74	6900	4	focused	focus	VBN
cord-015021-pol2qm74	6900	5	on	on	IN
cord-015021-pol2qm74	6900	6	studies	study	NNS
cord-015021-pol2qm74	6900	7	to	to	TO
cord-015021-pol2qm74	6900	8	define	define	VB
cord-015021-pol2qm74	6900	9	the	the	DT
cord-015021-pol2qm74	6900	10	safety	safety	NN
cord-015021-pol2qm74	6900	11	and	and	CC
cord-015021-pol2qm74	6900	12	efficacy	efficacy	NN
cord-015021-pol2qm74	6900	13	of	of	IN
cord-015021-pol2qm74	6900	14	this	this	DT
cord-015021-pol2qm74	6900	15	resuscitative	resuscitative	JJ
cord-015021-pol2qm74	6900	16	solutions	solution	NNS
cord-015021-pol2qm74	6900	17	.	.	.
cord-015021-pol2qm74	6901	1	LEH	LEH	NNP
cord-015021-pol2qm74	6901	2	consists	consist	VBZ
cord-015021-pol2qm74	6901	3	of	of	IN
cord-015021-pol2qm74	6901	4	distearoyl	distearoyl	NNP
cord-015021-pol2qm74	6901	5	phosphatidylcholine	phosphatidylcholine	NN
cord-015021-pol2qm74	6901	6	,	,	,
cord-015021-pol2qm74	6901	7	cholesterol	cholesterol	NN
cord-015021-pol2qm74	6901	8	,	,	,
cord-015021-pol2qm74	6901	9	dimyristoyl	dimyristoyl	NNP
cord-015021-pol2qm74	6901	10	phosphatidylglyeerol	phosphatidylglyeerol	NNP
cord-015021-pol2qm74	6901	11	,	,	,
cord-015021-pol2qm74	6901	12	and	and	CC
cord-015021-pol2qm74	6901	13	alpha	alpha	NN
cord-015021-pol2qm74	6901	14	tocopherol	tocopherol	NN
cord-015021-pol2qm74	6901	15	in	in	IN
cord-015021-pol2qm74	6901	16	a	a	DT
cord-015021-pol2qm74	6901	17	10:9:0.9:0.1	10:9:0.9:0.1	CD
cord-015021-pol2qm74	6901	18	mole	mole	NN
cord-015021-pol2qm74	6901	19	ratio	ratio	NN
cord-015021-pol2qm74	6901	20	and	and	CC
cord-015021-pol2qm74	6901	21	can	can	MD
cord-015021-pol2qm74	6901	22	encapsulate	encapsulate	VB
cord-015021-pol2qm74	6901	23	hemoglobins	hemoglobin	NNS
cord-015021-pol2qm74	6901	24	of	of	IN
cord-015021-pol2qm74	6901	25	different	different	JJ
cord-015021-pol2qm74	6901	26	origin	origin	NN
cord-015021-pol2qm74	6901	27	(	(	-LRB-
cord-015021-pol2qm74	6901	28	bovine	bovine	JJ
cord-015021-pol2qm74	6901	29	,	,	,
cord-015021-pol2qm74	6901	30	human	human	JJ
cord-015021-pol2qm74	6901	31	,	,	,
cord-015021-pol2qm74	6901	32	recombinant	recombinant	JJ
cord-015021-pol2qm74	6901	33	human	human	NN
cord-015021-pol2qm74	6901	34	)	)	-RRB-
cord-015021-pol2qm74	6901	35	.	.	.
cord-015021-pol2qm74	6902	1	LEH	LEH	NNP
cord-015021-pol2qm74	6902	2	is	be	VBZ
cord-015021-pol2qm74	6902	3	fabricated	fabricate	VBN
cord-015021-pol2qm74	6902	4	using	use	VBG
cord-015021-pol2qm74	6902	5	hydrodynamic	hydrodynamic	JJ
cord-015021-pol2qm74	6902	6	shear	shear	NN
cord-015021-pol2qm74	6902	7	to	to	TO
cord-015021-pol2qm74	6902	8	create	create	VB
cord-015021-pol2qm74	6902	9	an	an	DT
cord-015021-pol2qm74	6902	10	average	average	JJ
cord-015021-pol2qm74	6902	11	particle	particle	NN
cord-015021-pol2qm74	6902	12	size	size	NN
cord-015021-pol2qm74	6902	13	of	of	IN
cord-015021-pol2qm74	6902	14	0.3	0.3	CD
cord-015021-pol2qm74	6902	15	microns	micron	NNS
cord-015021-pol2qm74	6902	16	.	.	.
cord-015021-pol2qm74	6903	1	LEH	LEH	NNP
cord-015021-pol2qm74	6903	2	can	can	MD
cord-015021-pol2qm74	6903	3	be	be	VB
cord-015021-pol2qm74	6903	4	lyophilized	lyophilize	VBN
cord-015021-pol2qm74	6903	5	using	use	VBG
cord-015021-pol2qm74	6903	6	disaccharides	disaccharide	NNS
cord-015021-pol2qm74	6903	7	and	and	CC
cord-015021-pol2qm74	6903	8	stabilized	stabilize	VBN
cord-015021-pol2qm74	6903	9	in	in	IN
cord-015021-pol2qm74	6903	10	the	the	DT
cord-015021-pol2qm74	6903	11	dry	dry	JJ
cord-015021-pol2qm74	6903	12	state	state	NN
cord-015021-pol2qm74	6903	13	and	and	CC
cord-015021-pol2qm74	6903	14	easily	easily	RB
cord-015021-pol2qm74	6903	15	reconstituted	reconstitute	VBN
cord-015021-pol2qm74	6903	16	before	before	IN
cord-015021-pol2qm74	6903	17	administration	administration	NN
cord-015021-pol2qm74	6903	18	.	.	.
cord-015021-pol2qm74	6904	1	Histopathology	Histopathology	NNP
cord-015021-pol2qm74	6904	2	and	and	CC
cord-015021-pol2qm74	6904	3	clinical	clinical	JJ
cord-015021-pol2qm74	6904	4	chemistries	chemistry	NNS
cord-015021-pol2qm74	6904	5	indicate	indicate	VBP
cord-015021-pol2qm74	6904	6	that	that	IN
cord-015021-pol2qm74	6904	7	LEH	LEH	NNP
cord-015021-pol2qm74	6904	8	rapidly	rapidly	RB
cord-015021-pol2qm74	6904	9	accumulates	accumulate	VBZ
cord-015021-pol2qm74	6904	10	in	in	IN
cord-015021-pol2qm74	6904	11	tissue	tissue	NN
cord-015021-pol2qm74	6904	12	resident	resident	NN
cord-015021-pol2qm74	6904	13	macrophages	macrophage	NNS
cord-015021-pol2qm74	6904	14	in	in	IN
cord-015021-pol2qm74	6904	15	small	small	JJ
cord-015021-pol2qm74	6904	16	animals	animal	NNS
cord-015021-pol2qm74	6904	17	injected	inject	VBN
cord-015021-pol2qm74	6904	18	in	in	IN
cord-015021-pol2qm74	6904	19	the	the	DT
cord-015021-pol2qm74	6904	20	tail	tail	NN
cord-015021-pol2qm74	6904	21	vein	vein	NN
cord-015021-pol2qm74	6904	22	,	,	,
cord-015021-pol2qm74	6904	23	principaI1y	principaI1y	''
cord-015021-pol2qm74	6904	24	in	in	IN
cord-015021-pol2qm74	6904	25	the	the	DT
cord-015021-pol2qm74	6904	26	liver	liver	NN
cord-015021-pol2qm74	6904	27	and	and	CC
cord-015021-pol2qm74	6904	28	spleen	spleen	NNS
cord-015021-pol2qm74	6904	29	.	.	.
cord-015021-pol2qm74	6905	1	The	the	DT
cord-015021-pol2qm74	6905	2	consequences	consequence	NNS
cord-015021-pol2qm74	6905	3	of	of	IN
cord-015021-pol2qm74	6905	4	accumulation	accumulation	NN
cord-015021-pol2qm74	6905	5	in	in	IN
cord-015021-pol2qm74	6905	6	the	the	DT
cord-015021-pol2qm74	6905	7	reticuloendothelial	reticuloendothelial	JJ
cord-015021-pol2qm74	6905	8	system	system	NN
cord-015021-pol2qm74	6905	9	are	be	VBP
cord-015021-pol2qm74	6905	10	manifest	manifest	JJ
cord-015021-pol2qm74	6905	11	by	by	IN
cord-015021-pol2qm74	6905	12	transient	transient	JJ
cord-015021-pol2qm74	6905	13	increases	increase	NNS
cord-015021-pol2qm74	6905	14	in	in	IN
cord-015021-pol2qm74	6905	15	liver	liver	NN
cord-015021-pol2qm74	6905	16	transaminases	transaminase	NNS
cord-015021-pol2qm74	6905	17	(	(	-LRB-
cord-015021-pol2qm74	6905	18	AST	AST	NNP
cord-015021-pol2qm74	6905	19	,	,	,
cord-015021-pol2qm74	6905	20	ALT	ALT	NNP
cord-015021-pol2qm74	6905	21	)	)	-RRB-
cord-015021-pol2qm74	6905	22	,	,	,
cord-015021-pol2qm74	6905	23	bilirubin	bilirubin	NN
cord-015021-pol2qm74	6905	24	,	,	,
cord-015021-pol2qm74	6905	25	and	and	CC
cord-015021-pol2qm74	6905	26	BUN	bun	NN
cord-015021-pol2qm74	6905	27	over	over	IN
cord-015021-pol2qm74	6905	28	24	24	CD
cord-015021-pol2qm74	6905	29	-	-	SYM
cord-015021-pol2qm74	6905	30	48	48	CD
cord-015021-pol2qm74	6905	31	hours	hour	NNS
cord-015021-pol2qm74	6905	32	with	with	IN
cord-015021-pol2qm74	6905	33	no	no	DT
cord-015021-pol2qm74	6905	34	change	change	NN
cord-015021-pol2qm74	6905	35	in	in	IN
cord-015021-pol2qm74	6905	36	biliary	biliary	JJ
cord-015021-pol2qm74	6905	37	function	function	NN
cord-015021-pol2qm74	6905	38	(	(	-LRB-
cord-015021-pol2qm74	6905	39	GGT	GGT	NNP
cord-015021-pol2qm74	6905	40	,	,	,
cord-015021-pol2qm74	6905	41	aP	aP	NNP
cord-015021-pol2qm74	6905	42	)	)	-RRB-
cord-015021-pol2qm74	6905	43	.	.	.
cord-015021-pol2qm74	6906	1	Clearance	clearance	NN
cord-015021-pol2qm74	6906	2	through	through	IN
cord-015021-pol2qm74	6906	3	the	the	DT
cord-015021-pol2qm74	6906	4	liver	liver	NN
cord-015021-pol2qm74	6906	5	and	and	CC
cord-015021-pol2qm74	6906	6	spleen	spleen	NN
cord-015021-pol2qm74	6906	7	is	be	VBZ
cord-015021-pol2qm74	6906	8	observed	observe	VBN
cord-015021-pol2qm74	6906	9	over	over	IN
cord-015021-pol2qm74	6906	10	the	the	DT
cord-015021-pol2qm74	6906	11	course	course	NN
cord-015021-pol2qm74	6906	12	of	of	IN
cord-015021-pol2qm74	6906	13	1	1	CD
cord-015021-pol2qm74	6906	14	-	-	SYM
cord-015021-pol2qm74	6906	15	2-weeks	2-weeks	CD
cord-015021-pol2qm74	6906	16	.	.	.
cord-015021-pol2qm74	6907	1	More	More	JJR
cord-015021-pol2qm74	6907	2	recent	recent	JJ
cord-015021-pol2qm74	6907	3	attention	attention	NN
cord-015021-pol2qm74	6907	4	has	have	VBZ
cord-015021-pol2qm74	6907	5	been	be	VBN
cord-015021-pol2qm74	6907	6	focused	focus	VBN
cord-015021-pol2qm74	6907	7	on	on	IN
cord-015021-pol2qm74	6907	8	secondary	secondary	JJ
cord-015021-pol2qm74	6907	9	consequences	consequence	NNS
cord-015021-pol2qm74	6907	10	of	of	IN
cord-015021-pol2qm74	6907	11	LEH	LEH	NNP
cord-015021-pol2qm74	6907	12	administration	administration	NN
cord-015021-pol2qm74	6907	13	especially	especially	RB
cord-015021-pol2qm74	6907	14	with	with	IN
cord-015021-pol2qm74	6907	15	regard	regard	NN
cord-015021-pol2qm74	6907	16	to	to	IN
cord-015021-pol2qm74	6907	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	6907	18	eytokines	eytokine	NNS
cord-015021-pol2qm74	6907	19	.	.	.
cord-015021-pol2qm74	6908	1	LEH	LEH	NNP
cord-015021-pol2qm74	6908	2	does	do	VBZ
cord-015021-pol2qm74	6908	3	not	not	RB
cord-015021-pol2qm74	6908	4	elicit	elicit	VB
cord-015021-pol2qm74	6908	5	expression	expression	NN
cord-015021-pol2qm74	6908	6	of	of	IN
cord-015021-pol2qm74	6908	7	tumor	tumor	NN
cord-015021-pol2qm74	6908	8	necrosis	necrosis	NN
cord-015021-pol2qm74	6908	9	factor	factor	NN
cord-015021-pol2qm74	6908	10	in	in	IN
cord-015021-pol2qm74	6908	11	vivo	vivo	NN
cord-015021-pol2qm74	6908	12	and	and	CC
cord-015021-pol2qm74	6908	13	in	in	IN
cord-015021-pol2qm74	6908	14	isolated	isolate	VBN
cord-015021-pol2qm74	6908	15	macrophage	macrophage	NN
cord-015021-pol2qm74	6908	16	cultures	culture	NNS
cord-015021-pol2qm74	6908	17	,	,	,
cord-015021-pol2qm74	6908	18	but	but	CC
cord-015021-pol2qm74	6908	19	does	do	VBZ
cord-015021-pol2qm74	6908	20	result	result	VB
cord-015021-pol2qm74	6908	21	in	in	IN
cord-015021-pol2qm74	6908	22	a	a	DT
cord-015021-pol2qm74	6908	23	transient	transient	JJ
cord-015021-pol2qm74	6908	24	increase	increase	NN
cord-015021-pol2qm74	6908	25	in	in	IN
cord-015021-pol2qm74	6908	26	serum	serum	NN
cord-015021-pol2qm74	6908	27	IL-6	IL-6	NNP
cord-015021-pol2qm74	6908	28	.	.	.
cord-015021-pol2qm74	6909	1	We	-PRON-	PRP
cord-015021-pol2qm74	6909	2	have	have	VBP
cord-015021-pol2qm74	6909	3	also	also	RB
cord-015021-pol2qm74	6909	4	examined	examine	VBN
cord-015021-pol2qm74	6909	5	the	the	DT
cord-015021-pol2qm74	6909	6	interaction	interaction	NN
cord-015021-pol2qm74	6909	7	of	of	IN
cord-015021-pol2qm74	6909	8	LEH	LEH	NNP
cord-015021-pol2qm74	6909	9	with	with	IN
cord-015021-pol2qm74	6909	10	LPS	LPS	NNP
cord-015021-pol2qm74	6909	11	in	in	IN
cord-015021-pol2qm74	6909	12	vitro	vitro	FW
cord-015021-pol2qm74	6909	13	macrophage	macrophage	NN
cord-015021-pol2qm74	6909	14	culture	culture	NN
cord-015021-pol2qm74	6909	15	to	to	TO
cord-015021-pol2qm74	6909	16	further	further	RB
cord-015021-pol2qm74	6909	17	understand	understand	VB
cord-015021-pol2qm74	6909	18	how	how	WRB
cord-015021-pol2qm74	6909	19	this	this	DT
cord-015021-pol2qm74	6909	20	blood	blood	NN
cord-015021-pol2qm74	6909	21	substitute	substitute	NN
cord-015021-pol2qm74	6909	22	may	may	MD
cord-015021-pol2qm74	6909	23	effect	effect	VB
cord-015021-pol2qm74	6909	24	the	the	DT
cord-015021-pol2qm74	6909	25	immune	immune	JJ
cord-015021-pol2qm74	6909	26	system	system	NN
cord-015021-pol2qm74	6909	27	.	.	.
cord-015021-pol2qm74	6910	1	We	-PRON-	PRP
cord-015021-pol2qm74	6910	2	have	have	VBP
cord-015021-pol2qm74	6910	3	labeled	label	VBN
cord-015021-pol2qm74	6910	4	LEH	LEH	NNP
cord-015021-pol2qm74	6910	5	with	with	IN
cord-015021-pol2qm74	6910	6	technetium-99	technetium-99	NN
cord-015021-pol2qm74	6910	7	m	m	NN
cord-015021-pol2qm74	6910	8	(	(	-LRB-
cord-015021-pol2qm74	6910	9	99mTc	99mtc	NN
cord-015021-pol2qm74	6910	10	)	)	-RRB-
cord-015021-pol2qm74	6910	11	to	to	TO
cord-015021-pol2qm74	6910	12	study	study	VB
cord-015021-pol2qm74	6910	13	the	the	DT
cord-015021-pol2qm74	6910	14	biodistribution	biodistribution	NN
cord-015021-pol2qm74	6910	15	of	of	IN
cord-015021-pol2qm74	6910	16	LEH	LEH	NNP
cord-015021-pol2qm74	6910	17	non	non	NNP
cord-015021-pol2qm74	6910	18	-	-	VBZ
cord-015021-pol2qm74	6910	19	invasively	invasively	RB
cord-015021-pol2qm74	6910	20	in	in	IN
cord-015021-pol2qm74	6910	21	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	6910	22	rabbits	rabbit	NNS
cord-015021-pol2qm74	6910	23	.	.	.
cord-015021-pol2qm74	6911	1	Rabbits	rabbit	NNS
cord-015021-pol2qm74	6911	2	were	be	VBD
cord-015021-pol2qm74	6911	3	infused	infuse	VBN
cord-015021-pol2qm74	6911	4	with	with	IN
cord-015021-pol2qm74	6911	5	a	a	DT
cord-015021-pol2qm74	6911	6	25	25	CD
cord-015021-pol2qm74	6911	7	%	%	NN
cord-015021-pol2qm74	6911	8	topload	topload	NN
cord-015021-pol2qm74	6911	9	of	of	IN
cord-015021-pol2qm74	6911	10	LEH	LEH	NNP
cord-015021-pol2qm74	6911	11	(	(	-LRB-
cord-015021-pol2qm74	6911	12	200	200	CD
cord-015021-pol2qm74	6911	13	mg	mg	NN
cord-015021-pol2qm74	6911	14	of	of	IN
cord-015021-pol2qm74	6911	15	phospholipid	phospholipid	NN
cord-015021-pol2qm74	6911	16	,	,	,
cord-015021-pol2qm74	6911	17	2.5	2.5	CD
cord-015021-pol2qm74	6911	18	g	g	NN
cord-015021-pol2qm74	6911	19	of	of	IN
cord-015021-pol2qm74	6911	20	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6911	21	per	per	IN
cord-015021-pol2qm74	6911	22	kg	kg	NNS
cord-015021-pol2qm74	6911	23	of	of	IN
cord-015021-pol2qm74	6911	24	body	body	NN
cord-015021-pol2qm74	6911	25	weight	weight	NN
cord-015021-pol2qm74	6911	26	)	)	-RRB-
cord-015021-pol2qm74	6911	27	and	and	CC
cord-015021-pol2qm74	6911	28	imaged	image	VBD
cord-015021-pol2qm74	6911	29	continuously	continuously	RB
cord-015021-pol2qm74	6911	30	with	with	IN
cord-015021-pol2qm74	6911	31	a	a	DT
cord-015021-pol2qm74	6911	32	gamma	gamma	JJ
cord-015021-pol2qm74	6911	33	camera	camera	NN
cord-015021-pol2qm74	6911	34	.	.	.
cord-015021-pol2qm74	6912	1	At	at	IN
cord-015021-pol2qm74	6912	2	20	20	CD
cord-015021-pol2qm74	6912	3	hours	hour	NNS
cord-015021-pol2qm74	6912	4	,	,	,
cord-015021-pol2qm74	6912	5	images	image	NNS
cord-015021-pol2qm74	6912	6	were	be	VBD
cord-015021-pol2qm74	6912	7	again	again	RB
cord-015021-pol2qm74	6912	8	acquired	acquire	VBN
cord-015021-pol2qm74	6912	9	.	.	.
cord-015021-pol2qm74	6913	1	Animals	animal	NNS
cord-015021-pol2qm74	6913	2	were	be	VBD
cord-015021-pol2qm74	6913	3	then	then	RB
cord-015021-pol2qm74	6913	4	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	6913	5	and	and	CC
cord-015021-pol2qm74	6913	6	tissue	tissue	NN
cord-015021-pol2qm74	6913	7	counts	count	NNS
cord-015021-pol2qm74	6913	8	obtained	obtain	VBN
cord-015021-pol2qm74	6913	9	,	,	,
cord-015021-pol2qm74	6913	10	images	image	NNS
cord-015021-pol2qm74	6913	11	revealed	reveal	VBD
cord-015021-pol2qm74	6913	12	an	an	DT
cord-015021-pol2qm74	6913	13	initial	initial	JJ
cord-015021-pol2qm74	6913	14	rapid	rapid	JJ
cord-015021-pol2qm74	6913	15	uptake	uptake	NN
cord-015021-pol2qm74	6913	16	bythe	bythe	DT
cord-015021-pol2qm74	6913	17	liver	liver	NN
cord-015021-pol2qm74	6913	18	,	,	,
cord-015021-pol2qm74	6913	19	8	8	CD
cord-015021-pol2qm74	6913	20	%	%	NN
cord-015021-pol2qm74	6913	21	at	at	IN
cord-015021-pol2qm74	6913	22	30	30	CD
cord-015021-pol2qm74	6913	23	minutes	minute	NNS
cord-015021-pol2qm74	6913	24	and	and	CC
cord-015021-pol2qm74	6913	25	15	15	CD
cord-015021-pol2qm74	6913	26	%	%	NN
cord-015021-pol2qm74	6913	27	by	by	IN
cord-015021-pol2qm74	6913	28	2	2	CD
cord-015021-pol2qm74	6913	29	hours	hour	NNS
cord-015021-pol2qm74	6913	30	.	.	.
cord-015021-pol2qm74	6914	1	The	the	DT
cord-015021-pol2qm74	6914	2	spleen	spleen	NN
cord-015021-pol2qm74	6914	3	accumulated	accumulate	VBN
cord-015021-pol2qm74	6914	4	activity	activity	NN
cord-015021-pol2qm74	6914	5	at	at	IN
cord-015021-pol2qm74	6914	6	a	a	DT
cord-015021-pol2qm74	6914	7	slower	slow	JJR
cord-015021-pol2qm74	6914	8	rate	rate	NN
cord-015021-pol2qm74	6914	9	,	,	,
cord-015021-pol2qm74	6914	10	3	3	CD
cord-015021-pol2qm74	6914	11	%	%	NN
cord-015021-pol2qm74	6914	12	at	at	IN
cord-015021-pol2qm74	6914	13	30	30	CD
cord-015021-pol2qm74	6914	14	minutes	minute	NNS
cord-015021-pol2qm74	6914	15	and	and	CC
cord-015021-pol2qm74	6914	16	7	7	CD
cord-015021-pol2qm74	6914	17	%	%	NN
cord-015021-pol2qm74	6914	18	at	at	IN
cord-015021-pol2qm74	6914	19	2	2	CD
cord-015021-pol2qm74	6914	20	hours	hour	NNS
cord-015021-pol2qm74	6914	21	.	.	.
cord-015021-pol2qm74	6915	1	At	at	IN
cord-015021-pol2qm74	6915	2	20	20	CD
cord-015021-pol2qm74	6915	3	hours	hour	NNS
cord-015021-pol2qm74	6915	4	,	,	,
cord-015021-pol2qm74	6915	5	autopsy	autopsy	JJ
cord-015021-pol2qm74	6915	6	biodistribution	biodistribution	NN
cord-015021-pol2qm74	6915	7	studies	study	NNS
cord-015021-pol2qm74	6915	8	revealed	reveal	VBD
cord-015021-pol2qm74	6915	9	that	that	IN
cord-015021-pol2qm74	6915	10	approximately	approximately	RB
cord-015021-pol2qm74	6915	11	42.6	42.6	CD
cord-015021-pol2qm74	6915	12	%	%	NN
cord-015021-pol2qm74	6915	13	of	of	IN
cord-015021-pol2qm74	6915	14	the	the	DT
cord-015021-pol2qm74	6915	15	dose	dose	NN
cord-015021-pol2qm74	6915	16	is	be	VBZ
cord-015021-pol2qm74	6915	17	in	in	IN
cord-015021-pol2qm74	6915	18	the	the	DT
cord-015021-pol2qm74	6915	19	blood	blood	NN
cord-015021-pol2qm74	6915	20	pool	pool	NN
cord-015021-pol2qm74	6915	21	,	,	,
cord-015021-pol2qm74	6915	22	15.4	15.4	CD
cord-015021-pol2qm74	6915	23	%	%	NN
cord-015021-pol2qm74	6915	24	in	in	IN
cord-015021-pol2qm74	6915	25	liver	liver	NN
cord-015021-pol2qm74	6915	26	,	,	,
cord-015021-pol2qm74	6915	27	18.1	18.1	CD
cord-015021-pol2qm74	6915	28	%	%	NN
cord-015021-pol2qm74	6915	29	in	in	IN
cord-015021-pol2qm74	6915	30	spleen	spleen	NN
cord-015021-pol2qm74	6915	31	,	,	,
cord-015021-pol2qm74	6915	32	3.2	3.2	CD
cord-015021-pol2qm74	6915	33	%	%	NN
cord-015021-pol2qm74	6915	34	in	in	IN
cord-015021-pol2qm74	6915	35	lungs	lung	NNS
cord-015021-pol2qm74	6915	36	,	,	,
cord-015021-pol2qm74	6915	37	2.4	2.4	CD
cord-015021-pol2qm74	6915	38	%	%	NN
cord-015021-pol2qm74	6915	39	in	in	IN
cord-015021-pol2qm74	6915	40	muscle	muscle	NN
cord-015021-pol2qm74	6915	41	and	and	CC
cord-015021-pol2qm74	6915	42	1.6	1.6	CD
cord-015021-pol2qm74	6915	43	%	%	NN
cord-015021-pol2qm74	6915	44	in	in	IN
cord-015021-pol2qm74	6915	45	urine	urine	NN
cord-015021-pol2qm74	6915	46	,	,	,
cord-015021-pol2qm74	6915	47	with	with	IN
cord-015021-pol2qm74	6915	48	trace	trace	NN
cord-015021-pol2qm74	6915	49	levels	level	NNS
cord-015021-pol2qm74	6915	50	in	in	IN
cord-015021-pol2qm74	6915	51	kidney	kidney	NN
cord-015021-pol2qm74	6915	52	,	,	,
cord-015021-pol2qm74	6915	53	brain	brain	NN
cord-015021-pol2qm74	6915	54	and	and	CC
cord-015021-pol2qm74	6915	55	heart	heart	NN
cord-015021-pol2qm74	6915	56	(	(	-LRB-
cord-015021-pol2qm74	6915	57	<	<	NNP
cord-015021-pol2qm74	6915	58	1	1	CD
cord-015021-pol2qm74	6915	59	°	°	NN
cord-015021-pol2qm74	6915	60	/o	/o	NNP
cord-015021-pol2qm74	6915	61	)	)	-RRB-
cord-015021-pol2qm74	6915	62	.	.	.
cord-015021-pol2qm74	6916	1	In	in	IN
cord-015021-pol2qm74	6916	2	a	a	DT
cord-015021-pol2qm74	6916	3	hypovolemic	hypovolemic	JJ
cord-015021-pol2qm74	6916	4	model	model	NN
cord-015021-pol2qm74	6916	5	,	,	,
cord-015021-pol2qm74	6916	6	rats	rat	NNS
cord-015021-pol2qm74	6916	7	were	be	VBD
cord-015021-pol2qm74	6916	8	10	10	CD
cord-015021-pol2qm74	6916	9	%	%	NN
cord-015021-pol2qm74	6916	10	or	or	CC
cord-015021-pol2qm74	6916	11	50	50	CD
cord-015021-pol2qm74	6916	12	%	%	NN
cord-015021-pol2qm74	6916	13	exchange	exchange	NN
cord-015021-pol2qm74	6916	14	transfused	transfuse	VBN
cord-015021-pol2qm74	6916	15	with	with	IN
cord-015021-pol2qm74	6916	16	99mTc	99mTc	NNP
cord-015021-pol2qm74	6916	17	-	-	HYPH
cord-015021-pol2qm74	6916	18	LEH	leh	NN
cord-015021-pol2qm74	6916	19	.	.	.
cord-015021-pol2qm74	6917	1	In	in	IN
cord-015021-pol2qm74	6917	2	the	the	DT
cord-015021-pol2qm74	6917	3	10	10	CD
cord-015021-pol2qm74	6917	4	%	%	NN
cord-015021-pol2qm74	6917	5	exchange	exchange	NN
cord-015021-pol2qm74	6917	6	model	model	NN
cord-015021-pol2qm74	6917	7	,	,	,
cord-015021-pol2qm74	6917	8	99mTc	99mTc	NNP
cord-015021-pol2qm74	6917	9	-	-	HYPH
cord-015021-pol2qm74	6917	10	LEH	LEH	NNP
cord-015021-pol2qm74	6917	11	was	be	VBD
cord-015021-pol2qm74	6917	12	rapidly	rapidly	RB
cord-015021-pol2qm74	6917	13	taken	take	VBN
cord-015021-pol2qm74	6917	14	up	up	RP
cord-015021-pol2qm74	6917	15	by	by	IN
cord-015021-pol2qm74	6917	16	the	the	DT
cord-015021-pol2qm74	6917	17	liver	liver	NN
cord-015021-pol2qm74	6917	18	and	and	CC
cord-015021-pol2qm74	6917	19	spleen	spleen	NNS
cord-015021-pol2qm74	6917	20	with	with	IN
cord-015021-pol2qm74	6917	21	minimal	minimal	JJ
cord-015021-pol2qm74	6917	22	activity	activity	NN
cord-015021-pol2qm74	6917	23	in	in	IN
cord-015021-pol2qm74	6917	24	the	the	DT
cord-015021-pol2qm74	6917	25	circulation	circulation	NN
cord-015021-pol2qm74	6917	26	at	at	IN
cord-015021-pol2qm74	6917	27	20	20	CD
cord-015021-pol2qm74	6917	28	hours	hour	NNS
cord-015021-pol2qm74	6917	29	.	.	.
cord-015021-pol2qm74	6918	1	With	with	IN
cord-015021-pol2qm74	6918	2	the	the	DT
cord-015021-pol2qm74	6918	3	50	50	CD
cord-015021-pol2qm74	6918	4	%	%	NN
cord-015021-pol2qm74	6918	5	exchange	exchange	NN
cord-015021-pol2qm74	6918	6	,	,	,
cord-015021-pol2qm74	6918	7	50	50	CD
cord-015021-pol2qm74	6918	8	%	%	NN
cord-015021-pol2qm74	6918	9	of	of	IN
cord-015021-pol2qm74	6918	10	the	the	DT
cord-015021-pol2qm74	6918	11	LEH	LEH	NNP
cord-015021-pol2qm74	6918	12	was	be	VBD
cord-015021-pol2qm74	6918	13	in	in	IN
cord-015021-pol2qm74	6918	14	circulation	circulation	NN
cord-015021-pol2qm74	6918	15	at	at	IN
cord-015021-pol2qm74	6918	16	20	20	CD
cord-015021-pol2qm74	6918	17	hours	hour	NNS
cord-015021-pol2qm74	6918	18	.	.	.
cord-015021-pol2qm74	6919	1	The	the	DT
cord-015021-pol2qm74	6919	2	interaction	interaction	NN
cord-015021-pol2qm74	6919	3	of	of	IN
cord-015021-pol2qm74	6919	4	LEH	LEH	NNP
cord-015021-pol2qm74	6919	5	with	with	IN
cord-015021-pol2qm74	6919	6	platelets	platelet	NNS
cord-015021-pol2qm74	6919	7	labeled	label	VBN
cord-015021-pol2qm74	6919	8	with	with	IN
cord-015021-pol2qm74	6919	9	indium-111	indium-111	NNP
cord-015021-pol2qm74	6919	10	was	be	VBD
cord-015021-pol2qm74	6919	11	also	also	RB
cord-015021-pol2qm74	6919	12	studied	study	VBN
cord-015021-pol2qm74	6919	13	.	.	.
cord-015021-pol2qm74	6920	1	After	after	IN
cord-015021-pol2qm74	6920	2	infusion	infusion	NN
cord-015021-pol2qm74	6920	3	of	of	IN
cord-015021-pol2qm74	6920	4	LEH	LEH	NNP
cord-015021-pol2qm74	6920	5	,	,	,
cord-015021-pol2qm74	6920	6	the	the	DT
cord-015021-pol2qm74	6920	7	labeled	label	VBN
cord-015021-pol2qm74	6920	8	platelets	platelet	NNS
cord-015021-pol2qm74	6920	9	rapidly	rapidly	RB
cord-015021-pol2qm74	6920	10	moved	move	VBD
cord-015021-pol2qm74	6920	11	from	from	IN
cord-015021-pol2qm74	6920	12	the	the	DT
cord-015021-pol2qm74	6920	13	circulation	circulation	NN
cord-015021-pol2qm74	6920	14	to	to	IN
cord-015021-pol2qm74	6920	15	the	the	DT
cord-015021-pol2qm74	6920	16	lungs	lung	NNS
cord-015021-pol2qm74	6920	17	and	and	CC
cord-015021-pol2qm74	6920	18	liver	liver	NN
cord-015021-pol2qm74	6920	19	.	.	.
cord-015021-pol2qm74	6921	1	Over	over	IN
cord-015021-pol2qm74	6921	2	the	the	DT
cord-015021-pol2qm74	6921	3	next	next	JJ
cord-015021-pol2qm74	6921	4	30	30	CD
cord-015021-pol2qm74	6921	5	minutes	minute	NNS
cord-015021-pol2qm74	6921	6	,	,	,
cord-015021-pol2qm74	6921	7	the	the	DT
cord-015021-pol2qm74	6921	8	platelets	platelet	NNS
cord-015021-pol2qm74	6921	9	gradually	gradually	RB
cord-015021-pol2qm74	6921	10	returned	return	VBD
cord-015021-pol2qm74	6921	11	to	to	IN
cord-015021-pol2qm74	6921	12	circulation	circulation	NN
cord-015021-pol2qm74	6921	13	.	.	.
cord-015021-pol2qm74	6922	1	This	this	DT
cord-015021-pol2qm74	6922	2	effect	effect	NN
cord-015021-pol2qm74	6922	3	was	be	VBD
cord-015021-pol2qm74	6922	4	not	not	RB
cord-015021-pol2qm74	6922	5	seen	see	VBN
cord-015021-pol2qm74	6922	6	with	with	IN
cord-015021-pol2qm74	6922	7	Iiposomes	Iiposomes	NNP
cord-015021-pol2qm74	6922	8	of	of	IN
cord-015021-pol2qm74	6922	9	the	the	DT
cord-015021-pol2qm74	6922	10	same	same	JJ
cord-015021-pol2qm74	6922	11	lipid	lipid	NN
cord-015021-pol2qm74	6922	12	composition	composition	NN
cord-015021-pol2qm74	6922	13	but	but	CC
cord-015021-pol2qm74	6922	14	containing	contain	VBG
cord-015021-pol2qm74	6922	15	no	no	DT
cord-015021-pol2qm74	6922	16	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6922	17	.	.	.
cord-015021-pol2qm74	6923	1	Non	non	JJ
cord-015021-pol2qm74	6923	2	-	-	JJ
cord-015021-pol2qm74	6923	3	invasive	invasive	JJ
cord-015021-pol2qm74	6923	4	imaging	imaging	NN
cord-015021-pol2qm74	6923	5	is	be	VBZ
cord-015021-pol2qm74	6923	6	proving	prove	VBG
cord-015021-pol2qm74	6923	7	to	to	TO
cord-015021-pol2qm74	6923	8	be	be	VB
cord-015021-pol2qm74	6923	9	a	a	DT
cord-015021-pol2qm74	6923	10	very	very	RB
cord-015021-pol2qm74	6923	11	useful	useful	JJ
cord-015021-pol2qm74	6923	12	tool	tool	NN
cord-015021-pol2qm74	6923	13	for	for	IN
cord-015021-pol2qm74	6923	14	the	the	DT
cord-015021-pol2qm74	6923	15	investigation	investigation	NN
cord-015021-pol2qm74	6923	16	of	of	IN
cord-015021-pol2qm74	6923	17	LEH	LEH	NNP
cord-015021-pol2qm74	6923	18	.	.	.
cord-015021-pol2qm74	6924	1	The	the	DT
cord-015021-pol2qm74	6924	2	need	need	NN
cord-015021-pol2qm74	6924	3	for	for	IN
cord-015021-pol2qm74	6924	4	a	a	DT
cord-015021-pol2qm74	6924	5	safe	safe	JJ
cord-015021-pol2qm74	6924	6	,	,	,
cord-015021-pol2qm74	6924	7	efficacious	efficacious	JJ
cord-015021-pol2qm74	6924	8	and	and	CC
cord-015021-pol2qm74	6924	9	commercially	commercially	RB
cord-015021-pol2qm74	6924	10	viable	viable	JJ
cord-015021-pol2qm74	6924	11	blood	blood	NN
cord-015021-pol2qm74	6924	12	substitute	substitute	NN
cord-015021-pol2qm74	6924	13	is	be	VBZ
cord-015021-pol2qm74	6924	14	unequivocal	unequivocal	JJ
cord-015021-pol2qm74	6924	15	.	.	.
cord-015021-pol2qm74	6925	1	Of	of	IN
cord-015021-pol2qm74	6925	2	the	the	DT
cord-015021-pol2qm74	6925	3	several	several	JJ
cord-015021-pol2qm74	6925	4	strategies	strategy	NNS
cord-015021-pol2qm74	6925	5	pursued	pursue	VBN
cord-015021-pol2qm74	6925	6	to	to	TO
cord-015021-pol2qm74	6925	7	invent	invent	VB
cord-015021-pol2qm74	6925	8	an	an	DT
cord-015021-pol2qm74	6925	9	adequate	adequate	JJ
cord-015021-pol2qm74	6925	10	blood	blood	NN
cord-015021-pol2qm74	6925	11	substitute	substitute	NN
cord-015021-pol2qm74	6925	12	,	,	,
cord-015021-pol2qm74	6925	13	Liposome	liposome	NN
cord-015021-pol2qm74	6925	14	Entrapped	entrap	VBN
cord-015021-pol2qm74	6925	15	Hemoglobin	Hemoglobin	NNP
cord-015021-pol2qm74	6925	16	(	(	-LRB-
cord-015021-pol2qm74	6925	17	LEH	LEH	NNP
cord-015021-pol2qm74	6925	18	)	)	-RRB-
cord-015021-pol2qm74	6925	19	has	have	VBZ
cord-015021-pol2qm74	6925	20	been	be	VBN
cord-015021-pol2qm74	6925	21	already	already	RB
cord-015021-pol2qm74	6925	22	established	establish	VBN
cord-015021-pol2qm74	6925	23	as	as	IN
cord-015021-pol2qm74	6925	24	a	a	DT
cord-015021-pol2qm74	6925	25	leading	lead	VBG
cord-015021-pol2qm74	6925	26	possibility	possibility	NN
cord-015021-pol2qm74	6925	27	.	.	.
cord-015021-pol2qm74	6926	1	Major	major	JJ
cord-015021-pol2qm74	6926	2	advances	advance	NNS
cord-015021-pol2qm74	6926	3	in	in	IN
cord-015021-pol2qm74	6926	4	liposome	liposome	NN
cord-015021-pol2qm74	6926	5	technology	technology	NN
cord-015021-pol2qm74	6926	6	have	have	VBP
cord-015021-pol2qm74	6926	7	already	already	RB
cord-015021-pol2qm74	6926	8	resulted	result	VBN
cord-015021-pol2qm74	6926	9	in	in	IN
cord-015021-pol2qm74	6926	10	liposome	liposome	NN
cord-015021-pol2qm74	6926	11	preparations	preparation	NNS
cord-015021-pol2qm74	6926	12	compatible	compatible	JJ
cord-015021-pol2qm74	6926	13	with	with	IN
cord-015021-pol2qm74	6926	14	clinical	clinical	JJ
cord-015021-pol2qm74	6926	15	use	use	NN
cord-015021-pol2qm74	6926	16	for	for	IN
cord-015021-pol2qm74	6926	17	drug	drug	NN
cord-015021-pol2qm74	6926	18	delivery	delivery	NN
cord-015021-pol2qm74	6926	19	.	.	.
cord-015021-pol2qm74	6927	1	Recent	recent	JJ
cord-015021-pol2qm74	6927	2	technological	technological	JJ
cord-015021-pol2qm74	6927	3	advances	advance	NNS
cord-015021-pol2qm74	6927	4	made	make	VBN
cord-015021-pol2qm74	6927	5	by	by	IN
cord-015021-pol2qm74	6927	6	the	the	DT
cord-015021-pol2qm74	6927	7	U.S.	U.S.	NNP
cord-015021-pol2qm74	6927	8	Naval	Naval	NNP
cord-015021-pol2qm74	6927	9	Research	Research	NNP
cord-015021-pol2qm74	6927	10	Laboratories	Laboratories	NNP
cord-015021-pol2qm74	6927	11	resulted	result	VBD
cord-015021-pol2qm74	6927	12	in	in	IN
cord-015021-pol2qm74	6927	13	the	the	DT
cord-015021-pol2qm74	6927	14	capacity	capacity	NN
cord-015021-pol2qm74	6927	15	to	to	TO
cord-015021-pol2qm74	6927	16	entrap	entrap	VB
cord-015021-pol2qm74	6927	17	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6927	18	into	into	IN
cord-015021-pol2qm74	6927	19	liposomes	liposome	NNS
cord-015021-pol2qm74	6927	20	in	in	IN
cord-015021-pol2qm74	6927	21	a	a	DT
cord-015021-pol2qm74	6927	22	way	way	NN
cord-015021-pol2qm74	6927	23	which	which	WDT
cord-015021-pol2qm74	6927	24	secludes	seclude	VBZ
cord-015021-pol2qm74	6927	25	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6927	26	from	from	IN
cord-015021-pol2qm74	6927	27	interacting	interact	VBG
cord-015021-pol2qm74	6927	28	freely	freely	RB
cord-015021-pol2qm74	6927	29	with	with	IN
cord-015021-pol2qm74	6927	30	biological	biological	JJ
cord-015021-pol2qm74	6927	31	systems	system	NNS
cord-015021-pol2qm74	6927	32	.	.	.
cord-015021-pol2qm74	6928	1	The	the	DT
cord-015021-pol2qm74	6928	2	LEH	LEH	NNP
cord-015021-pol2qm74	6928	3	produced	produce	VBD
cord-015021-pol2qm74	6928	4	has	have	VBZ
cord-015021-pol2qm74	6928	5	already	already	RB
cord-015021-pol2qm74	6928	6	been	be	VBN
cord-015021-pol2qm74	6928	7	tested	test	VBN
cord-015021-pol2qm74	6928	8	in	in	RP
cord-015021-pol2qm74	6928	9	in	in	IN
cord-015021-pol2qm74	6928	10	vivo	vivo	NN
cord-015021-pol2qm74	6928	11	systems	system	NNS
cord-015021-pol2qm74	6928	12	and	and	CC
cord-015021-pol2qm74	6928	13	was	be	VBD
cord-015021-pol2qm74	6928	14	foun.d	foun.d	JJ
cord-015021-pol2qm74	6928	15	to	to	TO
cord-015021-pol2qm74	6928	16	be	be	VB
cord-015021-pol2qm74	6928	17	well	well	RB
cord-015021-pol2qm74	6928	18	tolerated	tolerate	VBN
cord-015021-pol2qm74	6928	19	.	.	.
cord-015021-pol2qm74	6929	1	Moreover	moreover	RB
cord-015021-pol2qm74	6929	2	,	,	,
cord-015021-pol2qm74	6929	3	the	the	DT
cord-015021-pol2qm74	6929	4	LEH	LEH	NNP
cord-015021-pol2qm74	6929	5	originally	originally	RB
cord-015021-pol2qm74	6929	6	produced	produce	VBD
cord-015021-pol2qm74	6929	7	as	as	IN
cord-015021-pol2qm74	6929	8	a	a	DT
cord-015021-pol2qm74	6929	9	solution	solution	NN
cord-015021-pol2qm74	6929	10	can	can	MD
cord-015021-pol2qm74	6929	11	be	be	VB
cord-015021-pol2qm74	6929	12	transformed	transform	VBN
cord-015021-pol2qm74	6929	13	into	into	IN
cord-015021-pol2qm74	6929	14	a	a	DT
cord-015021-pol2qm74	6929	15	lyophilized	lyophilized	JJ
cord-015021-pol2qm74	6929	16	form	form	NN
cord-015021-pol2qm74	6929	17	which	which	WDT
cord-015021-pol2qm74	6929	18	can	can	MD
cord-015021-pol2qm74	6929	19	be	be	VB
cord-015021-pol2qm74	6929	20	reconstituted	reconstitute	VBN
cord-015021-pol2qm74	6929	21	and	and	CC
cord-015021-pol2qm74	6929	22	delivered	deliver	VBN
cord-015021-pol2qm74	6929	23	as	as	IN
cord-015021-pol2qm74	6929	24	a	a	DT
cord-015021-pol2qm74	6929	25	fresh	fresh	JJ
cord-015021-pol2qm74	6929	26	solution	solution	NN
cord-015021-pol2qm74	6929	27	.	.	.
cord-015021-pol2qm74	6930	1	While	while	IN
cord-015021-pol2qm74	6930	2	important	important	JJ
cord-015021-pol2qm74	6930	3	milestones	milestone	NNS
cord-015021-pol2qm74	6930	4	in	in	IN
cord-015021-pol2qm74	6930	5	LEH	LEH	NNP
cord-015021-pol2qm74	6930	6	development	development	NN
cord-015021-pol2qm74	6930	7	for	for	IN
cord-015021-pol2qm74	6930	8	a	a	DT
cord-015021-pol2qm74	6930	9	practical	practical	JJ
cord-015021-pol2qm74	6930	10	blood	blood	NN
cord-015021-pol2qm74	6930	11	substitute	substitute	NN
cord-015021-pol2qm74	6930	12	have	have	VBP
cord-015021-pol2qm74	6930	13	been	be	VBN
cord-015021-pol2qm74	6930	14	achieved	achieve	VBN
cord-015021-pol2qm74	6930	15	,	,	,
cord-015021-pol2qm74	6930	16	several	several	JJ
cord-015021-pol2qm74	6930	17	issues	issue	NNS
cord-015021-pol2qm74	6930	18	remain	remain	VBP
cord-015021-pol2qm74	6930	19	to	to	TO
cord-015021-pol2qm74	6930	20	be	be	VB
cord-015021-pol2qm74	6930	21	explored	explore	VBN
cord-015021-pol2qm74	6930	22	.	.	.
cord-015021-pol2qm74	6931	1	Most	most	RBS
cord-015021-pol2qm74	6931	2	notably	notably	RB
cord-015021-pol2qm74	6931	3	,	,	,
cord-015021-pol2qm74	6931	4	the	the	DT
cord-015021-pol2qm74	6931	5	long	long	JJ
cord-015021-pol2qm74	6931	6	term	term	NN
cord-015021-pol2qm74	6931	7	consequences	consequence	NNS
cord-015021-pol2qm74	6931	8	of	of	IN
cord-015021-pol2qm74	6931	9	LEH	LEH	NNP
cord-015021-pol2qm74	6931	10	on	on	IN
cord-015021-pol2qm74	6931	11	host	host	NN
cord-015021-pol2qm74	6931	12	defense	defense	NN
cord-015021-pol2qm74	6931	13	mechanisms	mechanism	NNS
cord-015021-pol2qm74	6931	14	and	and	CC
cord-015021-pol2qm74	6931	15	,	,	,
cord-015021-pol2qm74	6931	16	in	in	IN
cord-015021-pol2qm74	6931	17	particular	particular	JJ
cord-015021-pol2qm74	6931	18	,	,	,
cord-015021-pol2qm74	6931	19	immune	immune	JJ
cord-015021-pol2qm74	6931	20	cell	cell	NN
cord-015021-pol2qm74	6931	21	function	function	NN
cord-015021-pol2qm74	6931	22	.	.	.
cord-015021-pol2qm74	6932	1	In	in	IN
cord-015021-pol2qm74	6932	2	addition	addition	NN
cord-015021-pol2qm74	6932	3	,	,	,
cord-015021-pol2qm74	6932	4	it	-PRON-	PRP
cord-015021-pol2qm74	6932	5	is	be	VBZ
cord-015021-pol2qm74	6932	6	important	important	JJ
cord-015021-pol2qm74	6932	7	to	to	TO
cord-015021-pol2qm74	6932	8	understand	understand	VB
cord-015021-pol2qm74	6932	9	more	more	JJR
cord-015021-pol2qm74	6932	10	fully	fully	RB
cord-015021-pol2qm74	6932	11	the	the	DT
cord-015021-pol2qm74	6932	12	metabolic	metabolic	JJ
cord-015021-pol2qm74	6932	13	fate	fate	NN
cord-015021-pol2qm74	6932	14	and	and	CC
cord-015021-pol2qm74	6932	15	repercussions	repercussion	NNS
cord-015021-pol2qm74	6932	16	of	of	IN
cord-015021-pol2qm74	6932	17	LEH	LEH	NNP
cord-015021-pol2qm74	6932	18	delivered	deliver	VBD
cord-015021-pol2qm74	6932	19	at	at	IN
cord-015021-pol2qm74	6932	20	clinically	clinically	RB
cord-015021-pol2qm74	6932	21	relevant	relevant	JJ
cord-015021-pol2qm74	6932	22	dose	dose	NN
cord-015021-pol2qm74	6932	23	/	/	SYM
cord-015021-pol2qm74	6932	24	schedule	schedule	NN
cord-015021-pol2qm74	6932	25	regimens	regimen	NNS
cord-015021-pol2qm74	6932	26	.	.	.
cord-015021-pol2qm74	6933	1	Finally	finally	RB
cord-015021-pol2qm74	6933	2	,	,	,
cord-015021-pol2qm74	6933	3	while	while	IN
cord-015021-pol2qm74	6933	4	LEH	LEH	NNP
cord-015021-pol2qm74	6933	5	is	be	VBZ
cord-015021-pol2qm74	6933	6	a	a	DT
cord-015021-pol2qm74	6933	7	highly	highly	RB
cord-015021-pol2qm74	6933	8	promising	promising	JJ
cord-015021-pol2qm74	6933	9	strategy	strategy	NN
cord-015021-pol2qm74	6933	10	for	for	IN
cord-015021-pol2qm74	6933	11	a	a	DT
cord-015021-pol2qm74	6933	12	blood	blood	NN
cord-015021-pol2qm74	6933	13	substitute	substitute	NN
cord-015021-pol2qm74	6933	14	,	,	,
cord-015021-pol2qm74	6933	15	the	the	DT
cord-015021-pol2qm74	6933	16	present	present	JJ
cord-015021-pol2qm74	6933	17	formulations	formulation	NNS
cord-015021-pol2qm74	6933	18	consist	consist	VBP
cord-015021-pol2qm74	6933	19	of	of	IN
cord-015021-pol2qm74	6933	20	human	human	JJ
cord-015021-pol2qm74	6933	21	hemoglobin	hemoglobin	NN
cord-015021-pol2qm74	6933	22	derived	derive	VBN
cord-015021-pol2qm74	6933	23	from	from	IN
cord-015021-pol2qm74	6933	24	human	human	JJ
cord-015021-pol2qm74	6933	25	blood	blood	NN
cord-015021-pol2qm74	6933	26	,	,	,
cord-015021-pol2qm74	6933	27	To	to	TO
cord-015021-pol2qm74	6933	28	improve	improve	VB
cord-015021-pol2qm74	6933	29	the	the	DT
cord-015021-pol2qm74	6933	30	safety	safety	NN
cord-015021-pol2qm74	6933	31	profile	profile	NN
cord-015021-pol2qm74	6933	32	,	,	,
cord-015021-pol2qm74	6933	33	a	a	DT
cord-015021-pol2qm74	6933	34	recombinant	recombinant	JJ
cord-015021-pol2qm74	6933	35	preparation	preparation	NN
cord-015021-pol2qm74	6933	36	for	for	IN
cord-015021-pol2qm74	6933	37	liposome	liposome	NN
cord-015021-pol2qm74	6933	38	entrapment	entrapment	NN
cord-015021-pol2qm74	6933	39	will	will	MD
cord-015021-pol2qm74	6933	40	be	be	VB
cord-015021-pol2qm74	6933	41	much	much	RB
cord-015021-pol2qm74	6933	42	desired	desire	VBN
cord-015021-pol2qm74	6933	43	,	,	,
cord-015021-pol2qm74	6933	44	Aa	Aa	NNP
cord-015021-pol2qm74	6933	45	-	-	HYPH
cord-015021-pol2qm74	6933	46	ginine	ginine	NNP
cord-015021-pol2qm74	6933	47	,	,	,
cord-015021-pol2qm74	6933	48	a	a	DT
cord-015021-pol2qm74	6933	49	semi	semi	JJ
cord-015021-pol2qm74	6933	50	-	-	JJ
cord-015021-pol2qm74	6933	51	essendai	essendai	JJ
cord-015021-pol2qm74	6933	52	dietary	dietary	JJ
cord-015021-pol2qm74	6933	53	amino	amino	NN
cord-015021-pol2qm74	6933	54	acid	acid	NN
cord-015021-pol2qm74	6933	55	,	,	,
cord-015021-pol2qm74	6933	56	possesses	possess	VBZ
cord-015021-pol2qm74	6933	57	several	several	JJ
cord-015021-pol2qm74	6933	58	unique	unique	JJ
cord-015021-pol2qm74	6933	59	and	and	CC
cord-015021-pol2qm74	6933	60	potentially	potentially	RB
cord-015021-pol2qm74	6933	61	pharmacologic	pharmacologic	JJ
cord-015021-pol2qm74	6933	62	properties	property	NNS
cord-015021-pol2qm74	6933	63	.	.	.
cord-015021-pol2qm74	6934	1	Argirdun	Argirdun	NNP
cord-015021-pol2qm74	6934	2	is	be	VBZ
cord-015021-pol2qm74	6934	3	a	a	DT
cord-015021-pol2qm74	6934	4	potent	potent	JJ
cord-015021-pol2qm74	6934	5	secretagogue	secretagogue	NN
cord-015021-pol2qm74	6934	6	for	for	IN
cord-015021-pol2qm74	6934	7	pituitary	pituitary	JJ
cord-015021-pol2qm74	6934	8	growth	growth	NN
cord-015021-pol2qm74	6934	9	hormone	hormone	NN
cord-015021-pol2qm74	6934	10	and	and	CC
cord-015021-pol2qm74	6934	11	prolacfin	prolacfin	NN
cord-015021-pol2qm74	6934	12	and	and	CC
cord-015021-pol2qm74	6934	13	for	for	IN
cord-015021-pol2qm74	6934	14	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	6934	15	insulin	insulin	NN
cord-015021-pol2qm74	6934	16	and	and	CC
cord-015021-pol2qm74	6934	17	glueagon	glueagon	NNP
cord-015021-pol2qm74	6934	18	;	;	:
cord-015021-pol2qm74	6934	19	it	-PRON-	PRP
cord-015021-pol2qm74	6934	20	modulates	modulate	VBZ
cord-015021-pol2qm74	6934	21	host	host	NN
cord-015021-pol2qm74	6934	22	protein	protein	NN
cord-015021-pol2qm74	6934	23	metabolism	metabolism	NN
cord-015021-pol2qm74	6934	24	by	by	IN
cord-015021-pol2qm74	6934	25	increasing	increase	VBG
cord-015021-pol2qm74	6934	26	nkmgen	nkmgen	NNP
cord-015021-pol2qm74	6934	27	retention	retention	NN
cord-015021-pol2qm74	6934	28	and	and	CC
cord-015021-pol2qm74	6934	29	enhancing	enhance	VBG
cord-015021-pol2qm74	6934	30	wound	wound	NN
cord-015021-pol2qm74	6934	31	collagen	collagen	NN
cord-015021-pol2qm74	6934	32	synthesis	synthesis	NN
cord-015021-pol2qm74	6934	33	.	.	.
cord-015021-pol2qm74	6935	1	It	-PRON-	PRP
cord-015021-pol2qm74	6935	2	also	also	RB
cord-015021-pol2qm74	6935	3	is	be	VBZ
cord-015021-pol2qm74	6935	4	a	a	DT
cord-015021-pol2qm74	6935	5	potent	potent	JJ
cord-015021-pol2qm74	6935	6	T	t	NN
cord-015021-pol2qm74	6935	7	call	call	NN
cord-015021-pol2qm74	6935	8	function	function	NN
cord-015021-pol2qm74	6935	9	regulator	regulator	NN
cord-015021-pol2qm74	6935	10	.	.	.
cord-015021-pol2qm74	6936	1	AIt	AIt	NNS
cord-015021-pol2qm74	6936	2	of	of	IN
cord-015021-pol2qm74	6936	3	these	these	DT
cord-015021-pol2qm74	6936	4	effects	effect	NNS
cord-015021-pol2qm74	6936	5	coupled	couple	VBN
cord-015021-pol2qm74	6936	6	with	with	IN
cord-015021-pol2qm74	6936	7	its	-PRON-	PRP$
cord-015021-pol2qm74	6936	8	relative	relative	JJ
cord-015021-pol2qm74	6936	9	lack	lack	NN
cord-015021-pol2qm74	6936	10	of	of	IN
cord-015021-pol2qm74	6936	11	toxicity	toxicity	NN
cord-015021-pol2qm74	6936	12	and	and	CC
cord-015021-pol2qm74	6936	13	safety	safety	NN
cord-015021-pol2qm74	6936	14	make	make	VBP
cord-015021-pol2qm74	6936	15	it	-PRON-	PRP
cord-015021-pol2qm74	6936	16	an	an	DT
cord-015021-pol2qm74	6936	17	a	a	NN
cord-015021-pol2qm74	6936	18	~	~	NFP
cord-015021-pol2qm74	6936	19	antive	antive	NNP
cord-015021-pol2qm74	6936	20	nulritionai	nulritionai	NNPS
cord-015021-pol2qm74	6936	21	pharmacologic	pharmacologic	NNP
cord-015021-pol2qm74	6936	22	agem	agem	NNPS
cord-015021-pol2qm74	6936	23	(	(	-LRB-
cord-015021-pol2qm74	6936	24	t	t	NN
cord-015021-pol2qm74	6936	25	)	)	-RRB-
cord-015021-pol2qm74	6936	26	.	.	.
cord-015021-pol2qm74	6937	1	Rodents	rodent	NNS
cord-015021-pol2qm74	6937	2	fed	feed	VBN
cord-015021-pol2qm74	6938	1	supplemeutal	supplemeutal	NNP
cord-015021-pol2qm74	6938	2	arginine	arginine	NNP
cord-015021-pol2qm74	6938	3	exhibit	exhibit	NN
cord-015021-pol2qm74	6938	4	increased	increase	VBD
cord-015021-pol2qm74	6938	5	thymSc	thymsc	CD
cord-015021-pol2qm74	6938	6	weight	weight	NN
cord-015021-pol2qm74	6938	7	which	which	WDT
cord-015021-pol2qm74	6938	8	is	be	VBZ
cord-015021-pol2qm74	6938	9	due	due	JJ
cord-015021-pol2qm74	6938	10	to	to	IN
cord-015021-pol2qm74	6938	11	increased	increase	VBN
cord-015021-pol2qm74	6938	12	numbers	number	NNS
cord-015021-pol2qm74	6938	13	of	of	IN
cord-015021-pol2qm74	6938	14	thymic	thymic	JJ
cord-015021-pol2qm74	6938	15	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	6938	16	present	present	JJ
cord-015021-pol2qm74	6938	17	in	in	IN
cord-015021-pol2qm74	6938	18	the	the	DT
cord-015021-pol2qm74	6938	19	gland	gland	NN
cord-015021-pol2qm74	6938	20	.	.	.
cord-015021-pol2qm74	6939	1	Thymic	Thymic	NNP
cord-015021-pol2qm74	6939	2	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	6939	3	from	from	IN
cord-015021-pol2qm74	6939	4	animals	animal	NNS
cord-015021-pol2qm74	6939	5	fed	feed	VBD
cord-015021-pol2qm74	6939	6	supplemental	supplemental	NNP
cord-015021-pol2qm74	6939	7	ar	ar	NNP
cord-015021-pol2qm74	6939	8	~	~	NFP
cord-015021-pol2qm74	6939	9	e	e	TO
cord-015021-pol2qm74	6939	10	demonstrate	demonstrate	VB
cord-015021-pol2qm74	6939	11	increased	increase	VBN
cord-015021-pol2qm74	6939	12	blastogenesis	blastogenesis	NN
cord-015021-pol2qm74	6939	13	in	in	IN
cord-015021-pol2qm74	6939	14	response	response	NN
cord-015021-pol2qm74	6939	15	to	to	IN
cord-015021-pol2qm74	6939	16	Coma	Coma	NNP
cord-015021-pol2qm74	6939	17	.	.	.
cord-015021-pol2qm74	6940	1	and	and	CC
cord-015021-pol2qm74	6940	2	PHA	PHA	NNP
cord-015021-pol2qm74	6940	3	(	(	-LRB-
cord-015021-pol2qm74	6940	4	2	2	CD
cord-015021-pol2qm74	6940	5	)	)	-RRB-
cord-015021-pol2qm74	6940	6	.	.	.
cord-015021-pol2qm74	6941	1	Peripheral	peripheral	JJ
cord-015021-pol2qm74	6941	2	blood	blood	NN
cord-015021-pol2qm74	6941	3	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	6941	4	from	from	IN
cord-015021-pol2qm74	6941	5	humans	human	NNS
cord-015021-pol2qm74	6941	6	given	give	VBN
cord-015021-pol2qm74	6941	7	supplemental	supplemental	JJ
cord-015021-pol2qm74	6941	8	arginine	arginine	NN
cord-015021-pol2qm74	6941	9	also	also	RB
cord-015021-pol2qm74	6941	10	have	have	VBP
cord-015021-pol2qm74	6941	11	heightened	heighten	VBN
cord-015021-pol2qm74	6941	12	mitogunic	mitogunic	NNP
cord-015021-pol2qm74	6941	13	responses	response	NNS
cord-015021-pol2qm74	6941	14	to	to	IN
cord-015021-pol2qm74	6941	15	mitogen	mitogen	NNP
cord-015021-pol2qm74	6941	16	or	or	CC
cord-015021-pol2qm74	6941	17	antigens	antigen	NNS
cord-015021-pol2qm74	6941	18	(	(	-LRB-
cord-015021-pol2qm74	6941	19	3	3	CD
cord-015021-pol2qm74	6941	20	)	)	-RRB-
cord-015021-pol2qm74	6941	21	.	.	.
cord-015021-pol2qm74	6942	1	In	in	IN
cord-015021-pol2qm74	6942	2	postsurgery	postsurgery	NNP
cord-015021-pol2qm74	6942	3	padents	padent	NNS
cord-015021-pol2qm74	6942	4	supplemental	supplemental	JJ
cord-015021-pol2qm74	6942	5	arginine	arginine	NN
cord-015021-pol2qm74	6942	6	abrogates	abrogate	VBZ
cord-015021-pol2qm74	6942	7	or	or	CC
cord-015021-pol2qm74	6942	8	diminishes	diminish	VBZ
cord-015021-pol2qm74	6942	9	the	the	DT
cord-015021-pol2qm74	6942	10	deleterious	deleterious	JJ
cord-015021-pol2qm74	6942	11	effects	effect	NNS
cord-015021-pol2qm74	6942	12	of	of	IN
cord-015021-pol2qm74	6942	13	trauma	trauma	NN
cord-015021-pol2qm74	6942	14	on	on	IN
cord-015021-pol2qm74	6942	15	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	6942	16	responsiveness	responsiveness	NN
cord-015021-pol2qm74	6942	17	and	and	CC
cord-015021-pol2qm74	6942	18	restores	restore	VBZ
cord-015021-pol2qm74	6942	19	peripheral	peripheral	JJ
cord-015021-pol2qm74	6942	20	blood	blood	NN
cord-015021-pol2qm74	6942	21	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	6942	22	responses	response	NNS
cord-015021-pol2qm74	6942	23	much	much	RB
cord-015021-pol2qm74	6942	24	faster	fast	RBR
cord-015021-pol2qm74	6942	25	than	than	IN
cord-015021-pol2qm74	6942	26	observed	observe	VBN
cord-015021-pol2qm74	6942	27	in	in	IN
cord-015021-pol2qm74	6942	28	controls	control	NNS
cord-015021-pol2qm74	6942	29	.	.	.
cord-015021-pol2qm74	6943	1	Overall	overall	JJ
cord-015021-pol2qm74	6943	2	host	host	NN
cord-015021-pol2qm74	6943	3	immunity	immunity	NN
cord-015021-pol2qm74	6943	4	is	be	VBZ
cord-015021-pol2qm74	6943	5	also	also	RB
cord-015021-pol2qm74	6943	6	enhanced	enhance	VBN
cord-015021-pol2qm74	6943	7	by	by	IN
cord-015021-pol2qm74	6943	8	arginine	arginine	NN
cord-015021-pol2qm74	6943	9	.	.	.
cord-015021-pol2qm74	6944	1	Allograft	Allograft	NNP
cord-015021-pol2qm74	6944	2	rejection	rejection	NN
cord-015021-pol2qm74	6944	3	is	be	VBZ
cord-015021-pol2qm74	6944	4	enhanced	enhance	VBN
cord-015021-pol2qm74	6944	5	and	and	CC
cord-015021-pol2qm74	6944	6	septic	septic	JJ
cord-015021-pol2qm74	6944	7	animals	animal	NNS
cord-015021-pol2qm74	6944	8	survive	survive	VBP
cord-015021-pol2qm74	6944	9	longer	long	RBR
cord-015021-pol2qm74	6944	10	when	when	WRB
cord-015021-pol2qm74	6944	11	given	give	VBN
cord-015021-pol2qm74	6944	12	supplemental	supplemental	JJ
cord-015021-pol2qm74	6944	13	arginine	arginine	NN
cord-015021-pol2qm74	6944	14	(	(	-LRB-
cord-015021-pol2qm74	6944	15	4	4	CD
cord-015021-pol2qm74	6944	16	)	)	-RRB-
cord-015021-pol2qm74	6944	17	.	.	.
cord-015021-pol2qm74	6945	1	Tumor	tumor	NN
cord-015021-pol2qm74	6945	2	bearing	bear	VBG
cord-015021-pol2qm74	6945	3	urginine	urginine	NN
cord-015021-pol2qm74	6945	4	-	-	HYPH
cord-015021-pol2qm74	6945	5	supplemented	supplement	VBN
cord-015021-pol2qm74	6945	6	animals	animal	NNS
cord-015021-pol2qm74	6945	7	have	have	VBP
cord-015021-pol2qm74	6945	8	decreased	decrease	VBN
cord-015021-pol2qm74	6945	9	tumor	tumor	NN
cord-015021-pol2qm74	6945	10	growth	growth	NN
cord-015021-pol2qm74	6945	11	and	and	CC
cord-015021-pol2qm74	6945	12	enhanced	enhanced	JJ
cord-015021-pol2qm74	6945	13	survival	survival	NN
cord-015021-pol2qm74	6945	14	(	(	-LRB-
cord-015021-pol2qm74	6945	15	i	i	NN
cord-015021-pol2qm74	6945	16	)	)	-RRB-
cord-015021-pol2qm74	6945	17	.	.	.
cord-015021-pol2qm74	6946	1	Lastly	lastly	RB
cord-015021-pol2qm74	6946	2	,	,	,
cord-015021-pol2qm74	6946	3	asgmine	asgmine	NNP
cord-015021-pol2qm74	6946	4	can	can	MD
cord-015021-pol2qm74	6946	5	induce	induce	VB
cord-015021-pol2qm74	6946	6	T	T	NNP
cord-015021-pol2qm74	6946	7	cell	cell	NN
cord-015021-pol2qm74	6946	8	maturation	maturation	NN
cord-015021-pol2qm74	6946	9	and	and	CC
cord-015021-pol2qm74	6946	10	T	t	NN
cord-015021-pol2qm74	6946	11	cell	cell	NN
cord-015021-pol2qm74	6946	12	mediated	mediate	VBD
cord-015021-pol2qm74	6946	13	responses	response	NNS
cord-015021-pol2qm74	6946	14	in	in	IN
cord-015021-pol2qm74	6946	15	athyrnic	athyrnic	NNP
cord-015021-pol2qm74	6946	16	nude	nude	JJ
cord-015021-pol2qm74	6946	17	mice	mouse	NNS
cord-015021-pol2qm74	6946	18	.	.	.
cord-015021-pol2qm74	6947	1	Arginine	arginine	NN
cord-015021-pol2qm74	6947	2	also	also	RB
cord-015021-pol2qm74	6947	3	has	have	VBZ
cord-015021-pol2qm74	6947	4	remarkable	remarkable	JJ
cord-015021-pol2qm74	6947	5	effects	effect	NNS
cord-015021-pol2qm74	6947	6	on	on	IN
cord-015021-pol2qm74	6947	7	host	host	NN
cord-015021-pol2qm74	6947	8	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6947	9	metabolism	metabolism	NN
cord-015021-pol2qm74	6947	10	post	post	JJ
cord-015021-pol2qm74	6947	11	-	-	NN
cord-015021-pol2qm74	6947	12	injury	injury	NN
cord-015021-pol2qm74	6947	13	.	.	.
cord-015021-pol2qm74	6948	1	In	in	IN
cord-015021-pol2qm74	6948	2	increases	increase	NNS
cord-015021-pol2qm74	6948	3	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6948	4	retention	retention	NN
cord-015021-pol2qm74	6948	5	in	in	IN
cord-015021-pol2qm74	6948	6	healthy	healthy	JJ
cord-015021-pol2qm74	6948	7	human	human	JJ
cord-015021-pol2qm74	6948	8	volunteers	volunteer	NNS
cord-015021-pol2qm74	6948	9	and	and	CC
cord-015021-pol2qm74	6948	10	in	in	IN
cord-015021-pol2qm74	6948	11	surgical	surgical	JJ
cord-015021-pol2qm74	6948	12	patients	patient	NNS
cord-015021-pol2qm74	6948	13	.	.	.
cord-015021-pol2qm74	6949	1	This	this	DT
cord-015021-pol2qm74	6949	2	beneficial	beneficial	JJ
cord-015021-pol2qm74	6949	3	effect	effect	NN
cord-015021-pol2qm74	6949	4	on	on	IN
cord-015021-pol2qm74	6949	5	overall	overall	JJ
cord-015021-pol2qm74	6949	6	nitrogen	nitrogen	NN
cord-015021-pol2qm74	6949	7	metabolism	metabolism	NN
cord-015021-pol2qm74	6949	8	is	be	VBZ
cord-015021-pol2qm74	6949	9	accompanied	accompany	VBN
cord-015021-pol2qm74	6949	10	by	by	IN
cord-015021-pol2qm74	6949	11	a	a	DT
cord-015021-pol2qm74	6949	12	unique	unique	JJ
cord-015021-pol2qm74	6949	13	effect	effect	NN
cord-015021-pol2qm74	6949	14	on	on	IN
cord-015021-pol2qm74	6949	15	the	the	DT
cord-015021-pol2qm74	6949	16	healing	healing	NN
cord-015021-pol2qm74	6949	17	wound	wound	NN
cord-015021-pol2qm74	6949	18	.	.	.
cord-015021-pol2qm74	6950	1	Supp]emental	Supp]emental	NNP
cord-015021-pol2qm74	6951	1	arginine	arginine	NN
cord-015021-pol2qm74	6951	2	increases	increase	NNS
cord-015021-pol2qm74	6951	3	wound	wound	VBP
cord-015021-pol2qm74	6951	4	collagen	collagen	NN
cord-015021-pol2qm74	6951	5	synthesis	synthesis	NN
cord-015021-pol2qm74	6951	6	which	which	WDT
cord-015021-pol2qm74	6951	7	also	also	RB
cord-015021-pol2qm74	6951	8	translates	translate	VBZ
cord-015021-pol2qm74	6951	9	into	into	IN
cord-015021-pol2qm74	6951	10	increased	increased	JJ
cord-015021-pol2qm74	6951	11	wound	wound	NN
cord-015021-pol2qm74	6951	12	breaking	break	VBG
cord-015021-pol2qm74	6951	13	strength	strength	NN
cord-015021-pol2qm74	6951	14	(	(	-LRB-
cord-015021-pol2qm74	6951	15	5	5	CD
cord-015021-pol2qm74	6951	16	)	)	-RRB-
cord-015021-pol2qm74	6951	17	.	.	.
cord-015021-pol2qm74	6952	1	Arginine	arginine	NN
cord-015021-pol2qm74	6952	2	has	have	VBZ
cord-015021-pol2qm74	6952	3	no	no	DT
cord-015021-pol2qm74	6952	4	effect	effect	NN
cord-015021-pol2qm74	6952	5	ou	ou	NNP
cord-015021-pol2qm74	6952	6	epithelialization	epithelialization	NN
cord-015021-pol2qm74	6952	7	.	.	.
cord-015021-pol2qm74	6953	1	Douglas	Douglas	NNP
cord-015021-pol2qm74	6953	2	W.	W.	NNP
cord-015021-pol2qm74	6953	3	Wilmom	Wilmom	NNP
cord-015021-pol2qm74	6953	4	,	,	,
cord-015021-pol2qm74	6953	5	M.D.	M.D.	NNP
cord-015021-pol2qm74	6953	6	Boston	Boston	NNP
cord-015021-pol2qm74	6953	7	,	,	,
cord-015021-pol2qm74	6953	8	MA	MA	NNP
cord-015021-pol2qm74	6953	9	Gintamine	Gintamine	NNP
cord-015021-pol2qm74	6953	10	is	be	VBZ
cord-015021-pol2qm74	6953	11	the	the	DT
cord-015021-pol2qm74	6953	12	most	most	RBS
cord-015021-pol2qm74	6953	13	abundant	abundant	JJ
cord-015021-pol2qm74	6953	14	amino	amino	NN
cord-015021-pol2qm74	6953	15	acid	acid	NN
cord-015021-pol2qm74	6953	16	in	in	IN
cord-015021-pol2qm74	6953	17	the	the	DT
cord-015021-pol2qm74	6953	18	body	body	NN
cord-015021-pol2qm74	6953	19	,	,	,
cord-015021-pol2qm74	6953	20	but	but	CC
cord-015021-pol2qm74	6953	21	it	-PRON-	PRP
cord-015021-pol2qm74	6953	22	has	have	VBZ
cord-015021-pol2qm74	6953	23	long	long	RB
cord-015021-pol2qm74	6953	24	been	be	VBN
cord-015021-pol2qm74	6953	25	considered	consider	VBN
cord-015021-pol2qm74	6953	26	a	a	DT
cord-015021-pol2qm74	6953	27	nonessential	nonessential	JJ
cord-015021-pol2qm74	6953	28	amino	amino	NN
cord-015021-pol2qm74	6953	29	aeid	aeid	NN
cord-015021-pol2qm74	6953	30	because	because	IN
cord-015021-pol2qm74	6953	31	it	-PRON-	PRP
cord-015021-pol2qm74	6953	32	is	be	VBZ
cord-015021-pol2qm74	6953	33	synthesized	synthesize	VBN
cord-015021-pol2qm74	6953	34	in	in	IN
cord-015021-pol2qm74	6953	35	many	many	JJ
cord-015021-pol2qm74	6953	36	tissues	tissue	NNS
cord-015021-pol2qm74	6953	37	.	.	.
cord-015021-pol2qm74	6954	1	FoHov	FoHov	NNP
cord-015021-pol2qm74	6954	2	~	~	NFP
cord-015021-pol2qm74	6954	3	g	g	NNP
cord-015021-pol2qm74	6954	4	st,~'vation~	st,~'vation~	,
cord-015021-pol2qm74	6954	5	injury	injury	NN
cord-015021-pol2qm74	6954	6	or	or	CC
cord-015021-pol2qm74	6954	7	infection	infection	NN
cord-015021-pol2qm74	6954	8	,	,	,
cord-015021-pol2qm74	6954	9	skeletal	skeletal	JJ
cord-015021-pol2qm74	6954	10	muscle	muscle	NN
cord-015021-pol2qm74	6954	11	pmteln	pmteln	NNP
cord-015021-pol2qm74	6954	12	inoresses	inoresses	NNP
cord-015021-pol2qm74	6954	13	its	-PRON-	PRP$
cord-015021-pol2qm74	6954	14	net	net	JJ
cord-015021-pol2qm74	6954	15	tale	tale	NN
cord-015021-pol2qm74	6954	16	of	of	IN
cord-015021-pol2qm74	6954	17	degradation	degradation	NN
cord-015021-pol2qm74	6954	18	and	and	CC
cord-015021-pol2qm74	6954	19	releases	release	VBZ
cord-015021-pol2qm74	6954	20	amino	amino	NN
cord-015021-pol2qm74	6954	21	acids	acid	NNS
cord-015021-pol2qm74	6954	22	into	into	IN
cord-015021-pol2qm74	6954	23	the	the	DT
cord-015021-pol2qm74	6954	24	blunds	blund	NNS
cord-015021-pol2qm74	6954	25	~	~	NFP
cord-015021-pol2qm74	6954	26	mm	mm	XX
cord-015021-pol2qm74	6954	27	at	at	IN
cord-015021-pol2qm74	6954	28	an	an	DT
cord-015021-pol2qm74	6954	29	aocelerared	aocelerared	JJ
cord-015021-pol2qm74	6954	30	rate	rate	NN
cord-015021-pol2qm74	6954	31	.	.	.
cord-015021-pol2qm74	6955	1	App	App	VBZ
cord-015021-pol2qm74	6955	2	~	~	NFP
cord-015021-pol2qm74	6955	3	o)~mately	o)~mately	RB
cord-015021-pol2qm74	6955	4	one	one	CD
cord-015021-pol2qm74	6955	5	-	-	HYPH
cord-015021-pol2qm74	6955	6	third	third	NN
cord-015021-pol2qm74	6955	7	of	of	IN
cord-015021-pol2qm74	6955	8	the	the	DT
cord-015021-pol2qm74	6955	9	amino	amino	NN
cord-015021-pol2qm74	6955	10	nitmgea	nitmgea	NNP
cord-015021-pol2qm74	6955	11	is	be	VBZ
cord-015021-pol2qm74	6955	12	ghitamine	ghitamine	NNP
cord-015021-pol2qm74	6955	13	,	,	,
cord-015021-pol2qm74	6955	14	which	which	WDT
cord-015021-pol2qm74	6955	15	is	be	VBZ
cord-015021-pol2qm74	6955	16	metabolized	metabolize	VBN
cord-015021-pol2qm74	6955	17	by	by	IN
cord-015021-pol2qm74	6955	18	the	the	DT
cord-015021-pol2qm74	6955	19	kidney	kidney	NN
cord-015021-pol2qm74	6955	20	where	where	WRB
cord-015021-pol2qm74	6955	21	it	-PRON-	PRP
cord-015021-pol2qm74	6955	22	parth:~pates	parth:~pate	VBZ
cord-015021-pol2qm74	6955	23	in	in	IN
cord-015021-pol2qm74	6955	24	acid	acid	NN
cord-015021-pol2qm74	6955	25	-	-	HYPH
cord-015021-pol2qm74	6955	26	base	base	NN
cord-015021-pol2qm74	6955	27	homeostasis	homeostasis	NN
cord-015021-pol2qm74	6955	28	,	,	,
cord-015021-pol2qm74	6955	29	is	be	VBZ
cord-015021-pol2qm74	6955	30	the	the	DT
cord-015021-pol2qm74	6955	31	primly	primly	NN
cord-015021-pol2qm74	6955	32	~	~	NFP
cord-015021-pol2qm74	6955	33	for	for	IN
cord-015021-pol2qm74	6955	34	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	6955	35	,	,	,
cord-015021-pol2qm74	6955	36	mac	mac	NNP
cord-015021-pol2qm74	6955	37	~	~	NNP
cord-015021-pol2qm74	6955	38	optmgcs	optmgcs	NNP
cord-015021-pol2qm74	6955	39	and	and	CC
cord-015021-pol2qm74	6955	40	untexocyms	untexocyms	NNP
cord-015021-pol2qm74	6955	41	,	,	,
cord-015021-pol2qm74	6955	42	and	and	CC
cord-015021-pol2qm74	6955	43	contm'butcs	contm'butcs	NNP
cord-015021-pol2qm74	6955	44	to	to	IN
cord-015021-pol2qm74	6955	45	the	the	DT
cord-015021-pol2qm74	6955	46	synthesis	synthesis	NN
cord-015021-pol2qm74	6955	47	of	of	IN
cord-015021-pol2qm74	6955	48	giumth~	giumth~	NNP
cord-015021-pol2qm74	6956	1	une	une	NNP
cord-015021-pol2qm74	6956	2	.	.	.
cord-015021-pol2qm74	6957	1	Olmamine	Olmamine	NNP
cord-015021-pol2qm74	6957	2	degrades	degrade	VBZ
cord-015021-pol2qm74	6957	3	slowly	slowly	RB
cord-015021-pol2qm74	6957	4	while	while	IN
cord-015021-pol2qm74	6957	5	in	in	IN
cord-015021-pol2qm74	6957	6	~olu	~olu	NNP
cord-015021-pol2qm74	6958	1	~ou	~ou	NNP
cord-015021-pol2qm74	6958	2	,	,	,
cord-015021-pol2qm74	6958	3	especially	especially	RB
cord-015021-pol2qm74	6958	4	at	at	IN
cord-015021-pol2qm74	6958	5	usual	usual	JJ
cord-015021-pol2qm74	6958	6	room	room	NN
cord-015021-pol2qm74	6958	7	teml	teml	NN
cord-015021-pol2qm74	6958	8	~	~	NFP
cord-015021-pol2qm74	6958	9	mtums	mtum	NNS
cord-015021-pol2qm74	6958	10	.	.	.
cord-015021-pol2qm74	6959	1	Because	because	IN
cord-015021-pol2qm74	6959	2	giulamine	giulamine	NNP
cord-015021-pol2qm74	6959	3	was	be	VBD
cord-015021-pol2qm74	6959	4	considered	consider	VBN
cord-015021-pol2qm74	6959	5	nonessential	nonessential	JJ
cord-015021-pol2qm74	6959	6	,	,	,
cord-015021-pol2qm74	6959	7	it	-PRON-	PRP
cord-015021-pol2qm74	6959	8	has	have	VBZ
cord-015021-pol2qm74	6959	9	beer	beer	NN
cord-015021-pol2qm74	6959	10	absent	absent	JJ
cord-015021-pol2qm74	6959	11	R'om	r'om	JJ
cord-015021-pol2qm74	6959	12	nil	nil	NN
cord-015021-pol2qm74	6959	13	intravenous	intravenous	JJ
cord-015021-pol2qm74	6959	14	and	and	CC
cord-015021-pol2qm74	6959	15	most	most	JJS
cord-015021-pol2qm74	6959	16	Gluts.mine	gluts.mine	PRP
cord-015021-pol2qm74	6959	17	should	should	MD
cord-015021-pol2qm74	6959	18	be	be	VB
cord-015021-pol2qm74	6959	19	considered	consider	VBN
cord-015021-pol2qm74	6959	20	a	a	DT
cord-015021-pol2qm74	6959	21	cendittona]ly	cendittona]ly	NN
cord-015021-pol2qm74	6959	22	essential	essential	JJ
cord-015021-pol2qm74	6959	23	nutrient	nutrient	NN
cord-015021-pol2qm74	6959	24	for	for	IN
cord-015021-pol2qm74	6959	25	individuals	individual	NNS
cord-015021-pol2qm74	6959	26	with	with	IN
cord-015021-pol2qm74	6959	27	serious	serious	JJ
cord-015021-pol2qm74	6959	28	ilinesses	ilinesse	NNS
cord-015021-pol2qm74	6959	29	,	,	,
cord-015021-pol2qm74	6959	30	uspccially	uspccially	RB
cord-015021-pol2qm74	6959	31	those	those	DT
cord-015021-pol2qm74	6959	32	confoanded	confoande	VBN
cord-015021-pol2qm74	6959	33	by	by	IN
cord-015021-pol2qm74	6959	34	infcctinn	infcctinn	NNP
cord-015021-pol2qm74	6959	35	and	and	CC
cord-015021-pol2qm74	6959	36	inflammation	inflammation	NN
cord-015021-pol2qm74	6959	37	.	.	.
cord-015021-pol2qm74	6960	1	Over	over	IN
cord-015021-pol2qm74	6960	2	the	the	DT
cord-015021-pol2qm74	6960	3	uc~:t	uc~:t	CD
cord-015021-pol2qm74	6960	4	5	5	CD
cord-015021-pol2qm74	6960	5	-	-	SYM
cord-015021-pol2qm74	6960	6	7	7	CD
cord-015021-pol2qm74	6960	7	years	year	NNS
cord-015021-pol2qm74	6960	8	,	,	,
cord-015021-pol2qm74	6960	9	glutamine	glutamine	NN
cord-015021-pol2qm74	6960	10	will	will	MD
cord-015021-pol2qm74	6960	11	be	be	VB
cord-015021-pol2qm74	6960	12	incorgorated	incorgorate	VBN
cord-015021-pol2qm74	6960	13	into	into	IN
cord-015021-pol2qm74	6960	14	most	most	JJS
cord-015021-pol2qm74	6960	15	feeding	feeding	NN
cord-015021-pol2qm74	6960	16	formulas	formula	NNS
cord-015021-pol2qm74	6960	17	designed	design	VBN
cord-015021-pol2qm74	6960	18	for	for	IN
cord-015021-pol2qm74	6960	19	patients	patient	NNS
cord-015021-pol2qm74	6960	20	with	with	IN
cord-015021-pol2qm74	6960	21	critical	critical	JJ
cord-015021-pol2qm74	6960	22	illness	illness	NN
cord-015021-pol2qm74	6960	23	.	.	.
cord-015021-pol2qm74	6961	1	526	526	CD
cord-015021-pol2qm74	6961	2	O]~GA-3	o]~ga-3	NN
cord-015021-pol2qm74	6961	3	PUFA	PUFA	NNS
cord-015021-pol2qm74	6962	1	There	there	EX
cord-015021-pol2qm74	6962	2	continues	continue	VBZ
cord-015021-pol2qm74	6962	3	to	to	IN
cord-015021-pol2qm74	6962	4	much	much	JJ
cord-015021-pol2qm74	6962	5	interest	interest	NN
cord-015021-pol2qm74	6962	6	in	in	IN
cord-015021-pol2qm74	6962	7	the	the	DT
cord-015021-pol2qm74	6962	8	application	application	NN
cord-015021-pol2qm74	6962	9	of	of	IN
cord-015021-pol2qm74	6962	10	the	the	DT
cord-015021-pol2qm74	6962	11	0mega-3	0mega-3	CD
cord-015021-pol2qm74	6962	12	PUFA	PUFA	NNP
cord-015021-pol2qm74	6962	13	in	in	IN
cord-015021-pol2qm74	6962	14	clinical	clinical	JJ
cord-015021-pol2qm74	6962	15	nutrition	nutrition	NN
cord-015021-pol2qm74	6962	16	.	.	.
cord-015021-pol2qm74	6963	1	The	the	DT
cord-015021-pol2qm74	6963	2	basic	basic	JJ
cord-015021-pol2qm74	6963	3	principle	principle	NN
cord-015021-pol2qm74	6963	4	has	have	VBZ
cord-015021-pol2qm74	6963	5	been	be	VBN
cord-015021-pol2qm74	6963	6	that	that	IN
cord-015021-pol2qm74	6963	7	the	the	DT
cord-015021-pol2qm74	6963	8	0mega-3	0mega-3	CD
cord-015021-pol2qm74	6963	9	PUFA	PUFA	NNP
cord-015021-pol2qm74	6963	10	will	will	MD
cord-015021-pol2qm74	6963	11	displace	displace	VB
cord-015021-pol2qm74	6963	12	arachidunic	arachidunic	JJ
cord-015021-pol2qm74	6963	13	acid	acid	NN
cord-015021-pol2qm74	6963	14	and	and	CC
cord-015021-pol2qm74	6963	15	result	result	VB
cord-015021-pol2qm74	6963	16	in	in	IN
cord-015021-pol2qm74	6963	17	a	a	DT
cord-015021-pol2qm74	6963	18	decrease	decrease	NN
cord-015021-pol2qm74	6963	19	in	in	IN
cord-015021-pol2qm74	6963	20	eic0san0id	eic0san0id	VBG
cord-015021-pol2qm74	6963	21	production	production	NN
cord-015021-pol2qm74	6963	22	.	.	.
cord-015021-pol2qm74	6964	1	In	in	IN
cord-015021-pol2qm74	6964	2	addition	addition	NN
cord-015021-pol2qm74	6964	3	these	these	DT
cord-015021-pol2qm74	6964	4	changes	change	NNS
cord-015021-pol2qm74	6964	5	in	in	IN
cord-015021-pol2qm74	6964	6	PUFA	PUFA	NNP
cord-015021-pol2qm74	6964	7	will	will	MD
cord-015021-pol2qm74	6964	8	after	after	IN
cord-015021-pol2qm74	6964	9	the	the	DT
cord-015021-pol2qm74	6964	10	physical	physical	JJ
cord-015021-pol2qm74	6964	11	characteristics	characteristic	NNS
cord-015021-pol2qm74	6964	12	of	of	IN
cord-015021-pol2qm74	6964	13	the	the	DT
cord-015021-pol2qm74	6964	14	membrane	membrane	NN
cord-015021-pol2qm74	6964	15	including	include	VBG
cord-015021-pol2qm74	6964	16	flujdity	flujdity	NN
cord-015021-pol2qm74	6964	17	,	,	,
cord-015021-pol2qm74	6964	18	receptor	receptor	NN
cord-015021-pol2qm74	6964	19	function	function	NN
cord-015021-pol2qm74	6964	20	and	and	CC
cord-015021-pol2qm74	6964	21	transmembrane	transmembrane	NN
cord-015021-pol2qm74	6964	22	signals	signal	NNS
cord-015021-pol2qm74	6964	23	.	.	.
cord-015021-pol2qm74	6965	1	Animal	animal	NN
cord-015021-pol2qm74	6965	2	studies	study	NNS
cord-015021-pol2qm74	6965	3	have	have	VBP
cord-015021-pol2qm74	6965	4	shown	show	VBN
cord-015021-pol2qm74	6965	5	that	that	IN
cord-015021-pol2qm74	6965	6	there	there	EX
cord-015021-pol2qm74	6965	7	is	be	VBZ
cord-015021-pol2qm74	6965	8	omega-3	omega-3	NN
cord-015021-pol2qm74	6965	9	incorporation	incorporation	NN
cord-015021-pol2qm74	6965	10	with	with	IN
cord-015021-pol2qm74	6965	11	continuou~	continuou~	NN
cord-015021-pol2qm74	6965	12	enteral	enteral	NN
cord-015021-pol2qm74	6965	13	feeding	feed	VBG
cord-015021-pol2qm74	6965	14	both	both	CC
cord-015021-pol2qm74	6965	15	in	in	IN
cord-015021-pol2qm74	6965	16	control	control	NN
cord-015021-pol2qm74	6965	17	and	and	CC
cord-015021-pol2qm74	6965	18	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	6965	19	animals	animal	NNS
cord-015021-pol2qm74	6965	20	within	within	IN
cord-015021-pol2qm74	6965	21	3	3	CD
cord-015021-pol2qm74	6965	22	days	day	NNS
cord-015021-pol2qm74	6965	23	.	.	.
cord-015021-pol2qm74	6966	1	This	this	DT
cord-015021-pol2qm74	6966	2	includes	include	VBZ
cord-015021-pol2qm74	6966	3	the	the	DT
cord-015021-pol2qm74	6966	4	liver	liver	NN
cord-015021-pol2qm74	6966	5	,	,	,
cord-015021-pol2qm74	6966	6	spleen	spleen	NNS
cord-015021-pol2qm74	6966	7	,	,	,
cord-015021-pol2qm74	6966	8	circulating	circulating	NN
cord-015021-pol2qm74	6966	9	and	and	CC
cord-015021-pol2qm74	6966	10	alveolar	alveolar	JJ
cord-015021-pol2qm74	6966	11	marc0phages	marc0phage	NNS
cord-015021-pol2qm74	6966	12	and	and	CC
cord-015021-pol2qm74	6966	13	the	the	DT
cord-015021-pol2qm74	6966	14	lung	lung	NN
cord-015021-pol2qm74	6966	15	.	.	.
cord-015021-pol2qm74	6967	1	This	this	DT
cord-015021-pol2qm74	6967	2	incorporation	incorporation	NN
cord-015021-pol2qm74	6967	3	resuls	resuls	NN
cord-015021-pol2qm74	6967	4	in	in	IN
cord-015021-pol2qm74	6967	5	significant	significant	JJ
cord-015021-pol2qm74	6967	6	changes	change	NNS
cord-015021-pol2qm74	6967	7	in	in	IN
cord-015021-pol2qm74	6967	8	the	the	DT
cord-015021-pol2qm74	6967	9	eicosan0id	eicosan0id	NNP
cord-015021-pol2qm74	6967	10	production	production	NN
cord-015021-pol2qm74	6967	11	including	include	VBG
cord-015021-pol2qm74	6967	12	PGF	PGF	NNP
cord-015021-pol2qm74	6967	13	2	2	CD
cord-015021-pol2qm74	6967	14	and	and	CC
cord-015021-pol2qm74	6967	15	ket0-PGFlalpha	ket0-pgflalpha	NN
cord-015021-pol2qm74	6967	16	.	.	.
cord-015021-pol2qm74	6968	1	There	there	EX
cord-015021-pol2qm74	6968	2	is	be	VBZ
cord-015021-pol2qm74	6968	3	improvement	improvement	NN
cord-015021-pol2qm74	6968	4	in	in	IN
cord-015021-pol2qm74	6968	5	the	the	DT
cord-015021-pol2qm74	6968	6	cardio	cardio	JJ
cord-015021-pol2qm74	6968	7	-	-	HYPH
cord-015021-pol2qm74	6968	8	vascular	vascular	JJ
cord-015021-pol2qm74	6968	9	reep0nse	reep0nse	NN
cord-015021-pol2qm74	6968	10	of	of	IN
cord-015021-pol2qm74	6968	11	these	these	DT
cord-015021-pol2qm74	6968	12	animals	animal	NNS
cord-015021-pol2qm74	6968	13	with	with	IN
cord-015021-pol2qm74	6968	14	~ecreamed	~ecreamed	CD
cord-015021-pol2qm74	6968	15	lactic	lactic	JJ
cord-015021-pol2qm74	6968	16	acidosis	acidosis	NN
cord-015021-pol2qm74	6968	17	and	and	CC
cord-015021-pol2qm74	6968	18	improved	improved	JJ
cord-015021-pol2qm74	6968	19	cardiac	cardiac	JJ
cord-015021-pol2qm74	6968	20	contractility	contractility	NN
cord-015021-pol2qm74	6968	21	.	.	.
cord-015021-pol2qm74	6969	1	As	as	RB
cord-015021-pol2qm74	6969	2	well	well	RB
cord-015021-pol2qm74	6969	3	there	there	EX
cord-015021-pol2qm74	6969	4	is	be	VBZ
cord-015021-pol2qm74	6969	5	improved	improve	VBN
cord-015021-pol2qm74	6969	6	immune	immune	JJ
cord-015021-pol2qm74	6969	7	function	function	NN
cord-015021-pol2qm74	6969	8	with	with	IN
cord-015021-pol2qm74	6969	9	improved	improve	VBN
cord-015021-pol2qm74	6969	10	T	T	NNP
cord-015021-pol2qm74	6969	11	cell	cell	NN
cord-015021-pol2qm74	6969	12	response	response	NN
cord-015021-pol2qm74	6969	13	to	to	IN
cord-015021-pol2qm74	6969	14	mit0gens	mit0gens	NNP
cord-015021-pol2qm74	6969	15	.	.	.
cord-015021-pol2qm74	6970	1	The	the	DT
cord-015021-pol2qm74	6970	2	~	~	NFP
cord-015021-pol2qm74	6970	3	of	of	IN
cord-015021-pol2qm74	6970	4	a	a	DT
cord-015021-pol2qm74	6970	5	mumber	mumber	NN
cord-015021-pol2qm74	6970	6	of	of	IN
cord-015021-pol2qm74	6970	7	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	6970	8	agents	agent	NNS
cord-015021-pol2qm74	6970	9	blocking	block	VBG
cord-015021-pol2qm74	6970	10	cicosanoid	cicosanoid	NN
cord-015021-pol2qm74	6970	11	production	production	NN
cord-015021-pol2qm74	6970	12	can	can	MD
cord-015021-pol2qm74	6970	13	enhance	enhance	VB
cord-015021-pol2qm74	6970	14	the	the	DT
cord-015021-pol2qm74	6970	15	cell	cell	NN
cord-015021-pol2qm74	6970	16	effects	effect	NNS
cord-015021-pol2qm74	6970	17	of	of	IN
cord-015021-pol2qm74	6970	18	0mega-3	0mega-3	CD
cord-015021-pol2qm74	6970	19	PUFA	PUFA	NNP
cord-015021-pol2qm74	6970	20	.	.	.
cord-015021-pol2qm74	6971	1	Clinical	clinical	JJ
cord-015021-pol2qm74	6971	2	studies	study	NNS
cord-015021-pol2qm74	6971	3	using	use	VBG
cord-015021-pol2qm74	6971	4	short	short	JJ
cord-015021-pol2qm74	6971	5	term	term	NN
cord-015021-pol2qm74	6971	6	entsral	entsral	JJ
cord-015021-pol2qm74	6971	7	nutrition	nutrition	NN
cord-015021-pol2qm74	6971	8	with	with	IN
cord-015021-pol2qm74	6971	9	0mega-3	0mega-3	CD
cord-015021-pol2qm74	6972	1	either	either	CC
cord-015021-pol2qm74	6972	2	alone	alone	RB
cord-015021-pol2qm74	6972	3	or	or	CC
cord-015021-pol2qm74	6972	4	with	with	IN
cord-015021-pol2qm74	6972	5	other	other	JJ
cord-015021-pol2qm74	6972	6	enteral	enteral	JJ
cord-015021-pol2qm74	6972	7	supplements	supplement	NNS
cord-015021-pol2qm74	6972	8	in	in	IN
cord-015021-pol2qm74	6972	9	a	a	DT
cord-015021-pol2qm74	6972	10	number	number	NN
cord-015021-pol2qm74	6972	11	of	of	IN
cord-015021-pol2qm74	6972	12	clinical	clinical	JJ
cord-015021-pol2qm74	6972	13	settings	setting	NNS
cord-015021-pol2qm74	6972	14	have	have	VBP
cord-015021-pol2qm74	6972	15	shown	show	VBN
cord-015021-pol2qm74	6972	16	significant	significant	JJ
cord-015021-pol2qm74	6972	17	0mesa-3	0mesa-3	CD
cord-015021-pol2qm74	6972	18	incorporation	incorporation	NN
cord-015021-pol2qm74	6972	19	and	and	CC
cord-015021-pol2qm74	6972	20	decreased	decrease	VBD
cord-015021-pol2qm74	6972	21	eicosan0id	eicosan0id	NNP
cord-015021-pol2qm74	6972	22	production	production	NN
cord-015021-pol2qm74	6972	23	.	.	.
cord-015021-pol2qm74	6973	1	These	these	DT
cord-015021-pol2qm74	6973	2	positive	positive	JJ
cord-015021-pol2qm74	6973	3	results	result	NNS
cord-015021-pol2qm74	6973	4	must	must	MD
cord-015021-pol2qm74	6973	5	be	be	VB
cord-015021-pol2qm74	6973	6	discussed	discuss	VBN
cord-015021-pol2qm74	6973	7	with	with	IN
cord-015021-pol2qm74	6973	8	the	the	DT
cord-015021-pol2qm74	6973	9	additional	additional	JJ
cord-015021-pol2qm74	6973	10	evidence	evidence	NN
cord-015021-pol2qm74	6973	11	that	that	IN
cord-015021-pol2qm74	6973	12	long	long	JJ
cord-015021-pol2qm74	6973	13	term	term	NN
cord-015021-pol2qm74	6973	14	omega-3	omega-3	NN
cord-015021-pol2qm74	6973	15	supplementation	supplementation	NN
cord-015021-pol2qm74	6973	16	decrease	decrease	NN
cord-015021-pol2qm74	6973	17	eic0san0id	eic0san0id	JJ
cord-015021-pol2qm74	6973	18	production	production	NN
cord-015021-pol2qm74	6973	19	but	but	CC
cord-015021-pol2qm74	6973	20	als0	als0	NN
cord-015021-pol2qm74	6973	21	induce	induce	VB
cord-015021-pol2qm74	6973	22	a	a	DT
cord-015021-pol2qm74	6973	23	state	state	NN
cord-015021-pol2qm74	6973	24	of	of	IN
cord-015021-pol2qm74	6973	25	immune	immune	JJ
cord-015021-pol2qm74	6973	26	suppression	suppression	NN
cord-015021-pol2qm74	6973	27	that	that	WDT
cord-015021-pol2qm74	6973	28	is	be	VBZ
cord-015021-pol2qm74	6973	29	capable	capable	JJ
cord-015021-pol2qm74	6973	30	of	of	IN
cord-015021-pol2qm74	6973	31	increasing	increase	VBG
cord-015021-pol2qm74	6973	32	transplant	transplant	NN
cord-015021-pol2qm74	6973	33	sunvival	sunvival	NN
cord-015021-pol2qm74	6973	34	.	.	.
cord-015021-pol2qm74	6974	1	These	these	DT
cord-015021-pol2qm74	6974	2	10ng	10ng	JJ
cord-015021-pol2qm74	6974	3	te~	te~	NNP
cord-015021-pol2qm74	6974	4	inune	inune	NNP
cord-015021-pol2qm74	6974	5	effects	effect	NNS
cord-015021-pol2qm74	6974	6	may	may	MD
cord-015021-pol2qm74	6974	7	benefit	benefit	VB
cord-015021-pol2qm74	6974	8	clinical	clinical	JJ
cord-015021-pol2qm74	6974	9	conditions	condition	NNS
cord-015021-pol2qm74	6974	10	including	include	VBG
cord-015021-pol2qm74	6974	11	rheumatoid	rheumatoid	NN
cord-015021-pol2qm74	6974	12	arthritis	arthritis	NN
cord-015021-pol2qm74	6974	13	and	and	CC
cord-015021-pol2qm74	6974	14	Cr0hn	Cr0hn	NNP
cord-015021-pol2qm74	6974	15	'	'	POS
cord-015021-pol2qm74	6974	16	disease	disease	NN
cord-015021-pol2qm74	6975	1	Early	early	JJ
cord-015021-pol2qm74	6975	2	enteral	enteral	JJ
cord-015021-pol2qm74	6975	3	nutrition	nutrition	NN
cord-015021-pol2qm74	6975	4	instituted	institute	VBD
cord-015021-pol2qm74	6975	5	i	i	NNP
cord-015021-pol2qm74	6975	6	~	~	CD
cord-015021-pol2qm74	6975	7	mediately	mediately	NNP
cord-015021-pol2qm74	6975	8	afte~	afte~	NNP
cord-015021-pol2qm74	6976	1	injury	injury	NN
cord-015021-pol2qm74	6976	2	will	will	MD
cord-015021-pol2qm74	6976	3	decrease	decrease	VB
cord-015021-pol2qm74	6976	4	the	the	DT
cord-015021-pol2qm74	6976	5	entry	entry	NN
cord-015021-pol2qm74	6976	6	of	of	IN
cord-015021-pol2qm74	6976	7	bacteria	bacteria	NNS
cord-015021-pol2qm74	6976	8	into	into	IN
cord-015021-pol2qm74	6976	9	the	the	DT
cord-015021-pol2qm74	6976	10	intestinal	intestinal	JJ
cord-015021-pol2qm74	6976	11	wall	wall	NN
cord-015021-pol2qm74	6976	12	and	and	CC
cord-015021-pol2qm74	6976	13	decrease	decrease	VB
cord-015021-pol2qm74	6976	14	the	the	DT
cord-015021-pol2qm74	6976	15	number	number	NN
cord-015021-pol2qm74	6976	16	of	of	IN
cord-015021-pol2qm74	6976	17	bacteria	bacteria	NNS
cord-015021-pol2qm74	6976	18	that	that	WDT
cord-015021-pol2qm74	6976	19	translocate	translocate	VBP
cord-015021-pol2qm74	6976	20	into	into	IN
cord-015021-pol2qm74	6976	21	the	the	DT
cord-015021-pol2qm74	6976	22	portal	portal	JJ
cord-015021-pol2qm74	6976	23	blood	blood	NN
cord-015021-pol2qm74	6976	24	.	.	.
cord-015021-pol2qm74	6977	1	These	these	DT
cord-015021-pol2qm74	6977	2	reductions	reduction	NNS
cord-015021-pol2qm74	6977	3	are	be	VBP
cord-015021-pol2qm74	6977	4	associated	associate	VBN
cord-015021-pol2qm74	6977	5	with	with	IN
cord-015021-pol2qm74	6977	6	&	&	CC
cord-015021-pol2qm74	6977	7	decreased	decreased	JJ
cord-015021-pol2qm74	6977	8	catabolic	catabolic	JJ
cord-015021-pol2qm74	6977	9	response	response	NN
cord-015021-pol2qm74	6977	10	,	,	,
cord-015021-pol2qm74	6977	11	decreased	decrease	VBD
cord-015021-pol2qm74	6977	12	plasma	plasma	NN
cord-015021-pol2qm74	6977	13	cortisnl	cortisnl	NNS
cord-015021-pol2qm74	6977	14	levels	level	NNS
cord-015021-pol2qm74	6977	15	,	,	,
cord-015021-pol2qm74	6977	16	end	end	NN
cord-015021-pol2qm74	6977	17	decreased	decrease	VBD
cord-015021-pol2qm74	6977	18	VMA	VMA	NNP
cord-015021-pol2qm74	6977	19	excretion	excretion	NN
cord-015021-pol2qm74	6977	20	in	in	IN
cord-015021-pol2qm74	6977	21	the	the	DT
cord-015021-pol2qm74	6977	22	urine	urine	NN
cord-015021-pol2qm74	6977	23	and	and	CC
cord-015021-pol2qm74	6977	24	prevention	prevention	NN
cord-015021-pol2qm74	6977	25	of	of	IN
cord-015021-pol2qm74	6977	26	mueosal	mueosal	NN
cord-015021-pol2qm74	6977	27	atrophy	atrophy	NN
cord-015021-pol2qm74	6977	28	.	.	.
cord-015021-pol2qm74	6978	1	SDecific	sdecific	JJ
cord-015021-pol2qm74	6978	2	nutrients	nutrient	NNS
cord-015021-pol2qm74	6978	3	also	also	RB
cord-015021-pol2qm74	6978	4	affect	affect	VBP
cord-015021-pol2qm74	6978	5	the	the	DT
cord-015021-pol2qm74	6978	6	transloeation	transloeation	NN
cord-015021-pol2qm74	6978	7	process	process	NN
cord-015021-pol2qm74	6978	8	.	.	.
cord-015021-pol2qm74	6979	1	Addition	addition	NN
cord-015021-pol2qm74	6979	2	of	of	IN
cord-015021-pol2qm74	6979	3	arginlne	arginlne	NNP
cord-015021-pol2qm74	6979	4	to	to	IN
cord-015021-pol2qm74	6979	5	the	the	DT
cord-015021-pol2qm74	6979	6	diet	diet	NN
cord-015021-pol2qm74	6979	7	significantly	significantly	RB
cord-015021-pol2qm74	6979	8	improves	improve	VBZ
cord-015021-pol2qm74	6979	9	the	the	DT
cord-015021-pol2qm74	6979	10	ability	ability	NN
cord-015021-pol2qm74	6979	11	to	to	TO
cord-015021-pol2qm74	6979	12	kill	kill	VB
cord-015021-pol2qm74	6979	13	translocated	translocate	VBN
cord-015021-pol2qm74	6979	14	organisms	organism	NNS
cord-015021-pol2qm74	6979	15	.	.	.
cord-015021-pol2qm74	6980	1	However	however	RB
cord-015021-pol2qm74	6980	2	.	.	.
cord-015021-pol2qm74	6981	1	translooetion	translooetion	NN
cord-015021-pol2qm74	6981	2	across	across	IN
cord-015021-pol2qm74	6981	3	the	the	DT
cord-015021-pol2qm74	6981	4	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	6981	5	barrier	barrier	NN
cord-015021-pol2qm74	6981	6	is	be	VBZ
cord-015021-pol2qm74	6981	7	not	not	RB
cord-015021-pol2qm74	6981	8	affected	affect	VBN
cord-015021-pol2qm74	6981	9	.	.	.
cord-015021-pol2qm74	6982	1	In	in	IN
cord-015021-pol2qm74	6982	2	contrast	contrast	NN
cord-015021-pol2qm74	6982	3	,	,	,
cord-015021-pol2qm74	6982	4	glutamine	glutamine	NN
cord-015021-pol2qm74	6982	5	diminishes	diminish	VBZ
cord-015021-pol2qm74	6982	6	the	the	DT
cord-015021-pol2qm74	6982	7	rate	rate	NN
cord-015021-pol2qm74	6982	8	of	of	IN
cord-015021-pol2qm74	6982	9	translooation	translooation	NN
cord-015021-pol2qm74	6982	10	across	across	IN
cord-015021-pol2qm74	6982	11	the	the	DT
cord-015021-pol2qm74	6982	12	Imtestinal	Imtestinal	NNP
cord-015021-pol2qm74	6982	13	barrier	barrier	NN
cord-015021-pol2qm74	6982	14	and	and	CC
cord-015021-pol2qm74	6982	15	also	also	RB
cord-015021-pol2qm74	6982	16	improves	improve	VBZ
cord-015021-pol2qm74	6982	17	killing	killing	NN
cord-015021-pol2qm74	6982	18	of	of	IN
cord-015021-pol2qm74	6982	19	the	the	DT
cord-015021-pol2qm74	6982	20	beetarla	beetarla	NN
cord-015021-pol2qm74	6982	21	that	that	WDT
cord-015021-pol2qm74	6982	22	do	do	VBP
cord-015021-pol2qm74	6982	23	translooate	translooate	NN
cord-015021-pol2qm74	6982	24	.	.	.
cord-015021-pol2qm74	6983	1	The	the	DT
cord-015021-pol2qm74	6983	2	omega	omega	NN
cord-015021-pol2qm74	6983	3	3	3	CD
cord-015021-pol2qm74	6983	4	fatty	fatty	JJ
cord-015021-pol2qm74	6983	5	acids	acid	NNS
cord-015021-pol2qm74	6983	6	in	in	IN
cord-015021-pol2qm74	6983	7	the	the	DT
cord-015021-pol2qm74	6983	8	form	form	NN
cord-015021-pol2qm74	6983	9	of	of	IN
cord-015021-pol2qm74	6983	10	fish	fish	NN
cord-015021-pol2qm74	6983	11	oil	oil	NN
cord-015021-pol2qm74	6983	12	slightly	slightly	RB
cord-015021-pol2qm74	6983	13	decrease	decrease	VBP
cord-015021-pol2qm74	6983	14	the	the	DT
cord-015021-pol2qm74	6983	15	rate	rate	NN
cord-015021-pol2qm74	6983	16	of	of	IN
cord-015021-pol2qm74	6983	17	translocation	translocation	NN
cord-015021-pol2qm74	6983	18	but	but	CC
cord-015021-pol2qm74	6983	19	more	more	RBR
cord-015021-pol2qm74	6983	20	significantly	significantly	RB
cord-015021-pol2qm74	6983	21	increase	increase	VB
cord-015021-pol2qm74	6983	22	the	the	DT
cord-015021-pol2qm74	6983	23	ability	ability	NN
cord-015021-pol2qm74	6983	24	of	of	IN
cord-015021-pol2qm74	6983	25	the	the	DT
cord-015021-pol2qm74	6983	26	animal	animal	NN
cord-015021-pol2qm74	6983	27	to	to	TO
cord-015021-pol2qm74	6983	28	kill	kill	VB
cord-015021-pol2qm74	6983	29	translo	translo	NNP
cord-015021-pol2qm74	6983	30	~	~	NFP
cord-015021-pol2qm74	6983	31	ated	ate	VBN
cord-015021-pol2qm74	6983	32	organisms	organism	NNS
cord-015021-pol2qm74	6983	33	,	,	,
cord-015021-pol2qm74	6983	34	All	all	DT
cord-015021-pol2qm74	6983	35	three	three	CD
cord-015021-pol2qm74	6983	36	dietary	dietary	JJ
cord-015021-pol2qm74	6983	37	additives	additive	NNS
cord-015021-pol2qm74	6983	38	,	,	,
cord-015021-pol2qm74	6983	39	i.e.	i.e.	FW
cord-015021-pol2qm74	6983	40	argini	argini	NNP
cord-015021-pol2qm74	6983	41	~	~	NNP
cord-015021-pol2qm74	6983	42	e	e	NNP
cord-015021-pol2qm74	6983	43	,	,	,
cord-015021-pol2qm74	6983	44	glu	glu	NNP
cord-015021-pol2qm74	6983	45	=	=	SYM
cord-015021-pol2qm74	6983	46	amine	amine	NN
cord-015021-pol2qm74	6983	47	and	and	CC
cord-015021-pol2qm74	6983	48	fish	fish	NN
cord-015021-pol2qm74	6983	49	nil	nil	NN
cord-015021-pol2qm74	6983	50	.	.	.
cord-015021-pol2qm74	6984	1	significantly	significantly	RB
cord-015021-pol2qm74	6984	2	improve	improve	VB
cord-015021-pol2qm74	6984	3	survival	survival	NN
cord-015021-pol2qm74	6984	4	,	,	,
cord-015021-pol2qm74	6984	5	hut	hut	NN
cord-015021-pol2qm74	6984	6	adding	add	VBG
cord-015021-pol2qm74	6984	7	glyoine	glyoine	NN
cord-015021-pol2qm74	6984	8	or	or	CC
cord-015021-pol2qm74	6984	9	medium	medium	JJ
cord-015021-pol2qm74	6984	10	chain	chain	NN
cord-015021-pol2qm74	6984	11	triglyeeridem	triglyeeridem	NNS
cord-015021-pol2qm74	6984	12	do	do	VBP
cord-015021-pol2qm74	6984	13	not	not	RB
cord-015021-pol2qm74	6984	14	,	,	,
cord-015021-pol2qm74	6984	15	Combinations	Combinations	NNPS
cord-015021-pol2qm74	6984	16	of	of	IN
cord-015021-pol2qm74	6984	17	srginine	srginine	NNP
cord-015021-pol2qm74	6984	18	and	and	CC
cord-015021-pol2qm74	6984	19	glutamlns	glutamlns	NNP
cord-015021-pol2qm74	6984	20	,	,	,
cord-015021-pol2qm74	6984	21	glutamine	glutamine	NN
cord-015021-pol2qm74	6984	22	and	and	CC
cord-015021-pol2qm74	6984	23	fish	fish	NN
cord-015021-pol2qm74	6984	24	oil	oil	NN
cord-015021-pol2qm74	6984	25	,	,	,
cord-015021-pol2qm74	6984	26	and	and	CC
cord-015021-pol2qm74	6984	27	fish	fish	VB
cord-015021-pol2qm74	6984	28	ell	ell	NNP
cord-015021-pol2qm74	6984	29	end	end	NN
cord-015021-pol2qm74	6984	30	arginine	arginine	NN
cord-015021-pol2qm74	6984	31	each	each	DT
cord-015021-pol2qm74	6984	32	improve	improve	VBP
cord-015021-pol2qm74	6984	33	survival	survival	NN
cord-015021-pol2qm74	6984	34	,	,	,
cord-015021-pol2qm74	6984	35	and	and	CC
cord-015021-pol2qm74	6984	36	to	to	IN
cord-015021-pol2qm74	6984	37	a	a	DT
cord-015021-pol2qm74	6984	38	greater	great	JJR
cord-015021-pol2qm74	6984	39	degree	degree	NN
cord-015021-pol2qm74	6984	40	than	than	IN
cord-015021-pol2qm74	6984	41	a	a	DT
cord-015021-pol2qm74	6984	42	combination	combination	NN
cord-015021-pol2qm74	6984	43	of	of	IN
cord-015021-pol2qm74	6984	44	all	all	DT
cord-015021-pol2qm74	6984	45	three	three	CD
cord-015021-pol2qm74	6984	46	.	.	.
cord-015021-pol2qm74	6985	1	These	these	DT
cord-015021-pol2qm74	6985	2	studies	study	NNS
cord-015021-pol2qm74	6985	3	add	add	VBP
cord-015021-pol2qm74	6985	4	further	further	JJ
cord-015021-pol2qm74	6985	5	evidence	evidence	NN
cord-015021-pol2qm74	6985	6	that	that	IN
cord-015021-pol2qm74	6985	7	translocation	translocation	NN
cord-015021-pol2qm74	6985	8	is	be	VBZ
cord-015021-pol2qm74	6985	9	an	an	DT
cord-015021-pol2qm74	6985	10	important	important	JJ
cord-015021-pol2qm74	6985	11	determinant	determinant	NN
cord-015021-pol2qm74	6985	12	of	of	IN
cord-015021-pol2qm74	6985	13	survival	survival	NN
cord-015021-pol2qm74	6985	14	after	after	IN
cord-015021-pol2qm74	6985	15	injury	injury	NN
cord-015021-pol2qm74	6985	16	,	,	,
cord-015021-pol2qm74	6985	17	Early	early	RB
cord-015021-pol2qm74	6985	18	feeding	feed	VBG
cord-015021-pol2qm74	6985	19	with	with	IN
cord-015021-pol2qm74	6985	20	immunonutrlent	immunonutrlent	NN
cord-015021-pol2qm74	6985	21	enriched	enrich	VBN
cord-015021-pol2qm74	6985	22	dices	dice	NNS
cord-015021-pol2qm74	6985	23	will	will	MD
cord-015021-pol2qm74	6985	24	improve	improve	VB
cord-015021-pol2qm74	6985	25	survival	survival	NN
cord-015021-pol2qm74	6985	26	and	and	CC
cord-015021-pol2qm74	6985	27	dsarease	dsarease	NN
cord-015021-pol2qm74	6985	28	transloeation	transloeation	NN
cord-015021-pol2qm74	6985	29	to	to	IN
cord-015021-pol2qm74	6985	30	varying	vary	VBG
cord-015021-pol2qm74	6985	31	degrees	degree	NNS
cord-015021-pol2qm74	6985	32	,	,	,
cord-015021-pol2qm74	6985	33	depending	depend	VBG
cord-015021-pol2qm74	6985	34	upon	upon	IN
cord-015021-pol2qm74	6985	35	the	the	DT
cord-015021-pol2qm74	6985	36	nutrients	nutrient	NNS
cord-015021-pol2qm74	6985	37	provided	provide	VBN
cord-015021-pol2qm74	6985	38	.	.	.
cord-015021-pol2qm74	6986	1	OBJECTIVES	objectives	NN
cord-015021-pol2qm74	6986	2	:	:	:
cord-015021-pol2qm74	6987	1	We	-PRON-	PRP
cord-015021-pol2qm74	6987	2	studied	study	VBD
cord-015021-pol2qm74	6987	3	effects	effect	NNS
cord-015021-pol2qm74	6987	4	of	of	IN
cord-015021-pol2qm74	6987	5	supplementing	supplement	VBG
cord-015021-pol2qm74	6987	6	a	a	DT
cord-015021-pol2qm74	6987	7	commercial	commercial	JJ
cord-015021-pol2qm74	6987	8	enteral	enteral	JJ
cord-015021-pol2qm74	6987	9	diet	diet	NN
cord-015021-pol2qm74	6987	10	,	,	,
cord-015021-pol2qm74	6987	11	Impact	impact	NN
cord-015021-pol2qm74	6987	12	R	R	NNP
cord-015021-pol2qm74	6987	13	(	(	-LRB-
cord-015021-pol2qm74	6987	14	IMP	IMP	NNP
cord-015021-pol2qm74	6987	15	,	,	,
cord-015021-pol2qm74	6987	16	Sander	Sander	NNP
cord-015021-pol2qm74	6987	17	Nutr	Nutr	NNP
cord-015021-pol2qm74	6987	18	lnc	lnc	NNP
cord-015021-pol2qm74	6987	19	)	)	-RRB-
cord-015021-pol2qm74	6987	20	,	,	,
cord-015021-pol2qm74	6987	21	with	with	IN
cord-015021-pol2qm74	6987	22	fiber	fiber	NN
cord-015021-pol2qm74	6987	23	(	(	-LRB-
cord-015021-pol2qm74	6987	24	IMP	IMP	NNP
cord-015021-pol2qm74	6987	25	/	/	SYM
cord-015021-pol2qm74	6987	26	FIB	FIB	NNP
cord-015021-pol2qm74	6987	27	)	)	-RRB-
cord-015021-pol2qm74	6987	28	or	or	CC
cord-015021-pol2qm74	6987	29	alanyl	alanyl	NN
cord-015021-pol2qm74	6987	30	-	-	HYPH
cord-015021-pol2qm74	6987	31	glutamine	glutamine	NN
cord-015021-pol2qm74	6987	32	(	(	-LRB-
cord-015021-pol2qm74	6987	33	IMP	IMP	NNP
cord-015021-pol2qm74	6987	34	/	/	SYM
cord-015021-pol2qm74	6987	35	AG	AG	NNP
cord-015021-pol2qm74	6987	36	,	,	,
cord-015021-pol2qm74	6987	37	exogenous	exogenous	JJ
cord-015021-pol2qm74	6987	38	glutamine	glutamine	NN
cord-015021-pol2qm74	6987	39	(	(	-LRB-
cord-015021-pol2qm74	6987	40	GLN	GLN	NNP
cord-015021-pol2qm74	6987	41	)	)	-RRB-
cord-015021-pol2qm74	6987	42	14	14	CD
cord-015021-pol2qm74	6987	43	gms	gms	NN
cord-015021-pol2qm74	6987	44	/	/	SYM
cord-015021-pol2qm74	6987	45	L	L	NNP
cord-015021-pol2qm74	6987	46	)	)	-RRB-
cord-015021-pol2qm74	6987	47	on	on	IN
cord-015021-pol2qm74	6987	48	influencing	influence	VBG
cord-015021-pol2qm74	6987	49	the	the	DT
cord-015021-pol2qm74	6987	50	incidence	incidence	NN
cord-015021-pol2qm74	6987	51	of	of	IN
cord-015021-pol2qm74	6987	52	BT	BT	NNP
cord-015021-pol2qm74	6987	53	to	to	IN
cord-015021-pol2qm74	6987	54	mesenteric	mesenteric	JJ
cord-015021-pol2qm74	6987	55	lymph	lymph	NN
cord-015021-pol2qm74	6987	56	nodes	node	NNS
cord-015021-pol2qm74	6987	57	(	(	-LRB-
cord-015021-pol2qm74	6987	58	MLN	mln	NN
cord-015021-pol2qm74	6987	59	)	)	-RRB-
cord-015021-pol2qm74	6987	60	in	in	IN
cord-015021-pol2qm74	6987	61	burned	burn	VBN
cord-015021-pol2qm74	6987	62	mice	mouse	NNS
cord-015021-pol2qm74	6987	63	.	.	.
cord-015021-pol2qm74	6988	1	Fiber	fiber	NN
cord-015021-pol2qm74	6988	2	has	have	VBZ
cord-015021-pol2qm74	6988	3	been	be	VBN
cord-015021-pol2qm74	6988	4	shown	show	VBN
cord-015021-pol2qm74	6988	5	to	to	TO
cord-015021-pol2qm74	6988	6	improve	improve	VB
cord-015021-pol2qm74	6988	7	GI	GI	NNP
cord-015021-pol2qm74	6988	8	integrity	integrity	NN
cord-015021-pol2qm74	6988	9	under	under	IN
cord-015021-pol2qm74	6988	10	certain	certain	JJ
cord-015021-pol2qm74	6988	11	stress	stress	NN
cord-015021-pol2qm74	6988	12	/	/	SYM
cord-015021-pol2qm74	6988	13	treatment	treatment	NN
cord-015021-pol2qm74	6988	14	conditions	condition	NNS
cord-015021-pol2qm74	6988	15	.	.	.
cord-015021-pol2qm74	6989	1	The	the	DT
cord-015021-pol2qm74	6989	2	dipeptide	dipeptide	JJ
cord-015021-pol2qm74	6989	3	AG	AG	NNP
cord-015021-pol2qm74	6989	4	is	be	VBZ
cord-015021-pol2qm74	6989	5	a	a	DT
cord-015021-pol2qm74	6989	6	water	water	NN
cord-015021-pol2qm74	6989	7	-	-	HYPH
cord-015021-pol2qm74	6989	8	stable	stable	JJ
cord-015021-pol2qm74	6989	9	source	source	NN
cord-015021-pol2qm74	6989	10	of	of	IN
cord-015021-pol2qm74	6989	11	GLN	GLN	NNP
cord-015021-pol2qm74	6989	12	,	,	,
cord-015021-pol2qm74	6989	13	which	which	WDT
cord-015021-pol2qm74	6989	14	is	be	VBZ
cord-015021-pol2qm74	6989	15	a	a	DT
cord-015021-pol2qm74	6989	16	specific	specific	JJ
cord-015021-pol2qm74	6989	17	fuel	fuel	NN
cord-015021-pol2qm74	6989	18	for	for	IN
cord-015021-pol2qm74	6989	19	many	many	JJ
cord-015021-pol2qm74	6989	20	cells	cell	NNS
cord-015021-pol2qm74	6989	21	including	include	VBG
cord-015021-pol2qm74	6989	22	enterocytes	enterocyte	NNS
cord-015021-pol2qm74	6989	23	.	.	.
cord-015021-pol2qm74	6990	1	TraumaCal	TraumaCal	NNP
cord-015021-pol2qm74	6990	2	(	(	-LRB-
cord-015021-pol2qm74	6990	3	TRCAL	TRCAL	NNP
cord-015021-pol2qm74	6990	4	)	)	-RRB-
cord-015021-pol2qm74	6990	5	,	,	,
cord-015021-pol2qm74	6990	6	a	a	DT
cord-015021-pol2qm74	6990	7	high	high	JJ
cord-015021-pol2qm74	6990	8	-	-	HYPH
cord-015021-pol2qm74	6990	9	protein	protein	NN
cord-015021-pol2qm74	6990	10	,	,	,
cord-015021-pol2qm74	6990	11	high	high	JJ
cord-015021-pol2qm74	6990	12	-	-	HYPH
cord-015021-pol2qm74	6990	13	fat	fat	NN
cord-015021-pol2qm74	6990	14	enteral	enteral	JJ
cord-015021-pol2qm74	6990	15	diet	diet	NN
cord-015021-pol2qm74	6990	16	(	(	-LRB-
cord-015021-pol2qm74	6990	17	Mead	Mead	NNP
cord-015021-pol2qm74	6990	18	Johnson	Johnson	NNP
cord-015021-pol2qm74	6990	19	Iuc	Iuc	NNP
cord-015021-pol2qm74	6990	20	)	)	-RRB-
cord-015021-pol2qm74	6990	21	,	,	,
cord-015021-pol2qm74	6990	22	was	be	VBD
cord-015021-pol2qm74	6990	23	also	also	RB
cord-015021-pol2qm74	6990	24	studied	study	VBN
cord-015021-pol2qm74	6990	25	,	,	,
cord-015021-pol2qm74	6990	26	as	as	RB
cord-015021-pol2qm74	6990	27	well	well	RB
cord-015021-pol2qm74	6990	28	as	as	IN
cord-015021-pol2qm74	6990	29	Rodent	Rodent	NNP
cord-015021-pol2qm74	6990	30	Chow	Chow	NNP
cord-015021-pol2qm74	6990	31	(	(	-LRB-
cord-015021-pol2qm74	6990	32	Harlan	Harlan	NNP
cord-015021-pol2qm74	6990	33	Teklad	Teklad	NNP
cord-015021-pol2qm74	6990	34	Inc	Inc	NNP
cord-015021-pol2qm74	6990	35	)	)	-RRB-
cord-015021-pol2qm74	6990	36	,	,	,
cord-015021-pol2qm74	6990	37	which	which	WDT
cord-015021-pol2qm74	6990	38	contains	contain	VBZ
cord-015021-pol2qm74	6990	39	very	very	RB
cord-015021-pol2qm74	6990	40	high	high	JJ
cord-015021-pol2qm74	6990	41	protein	protein	NN
cord-015021-pol2qm74	6990	42	&	&	CC
cord-015021-pol2qm74	6990	43	fiber	fiber	NN
cord-015021-pol2qm74	6990	44	.	.	.
cord-015021-pol2qm74	6991	1	METHODS	methods	NN
cord-015021-pol2qm74	6991	2	:	:	:
cord-015021-pol2qm74	6992	1	Anesthetized	anesthetize	VBN
cord-015021-pol2qm74	6992	2	CF-1	CF-1	NNP
cord-015021-pol2qm74	6992	3	mice	mouse	NNS
cord-015021-pol2qm74	6992	4	aged	age	VBN
cord-015021-pol2qm74	6992	5	8	8	CD
cord-015021-pol2qm74	6992	6	-	-	SYM
cord-015021-pol2qm74	6992	7	12	12	CD
cord-015021-pol2qm74	6992	8	wks	wks	NN
cord-015021-pol2qm74	6992	9	received	receive	VBD
cord-015021-pol2qm74	6992	10	32	32	CD
cord-015021-pol2qm74	6992	11	%	%	NN
cord-015021-pol2qm74	6992	12	TBSA	TBSA	NNP
cord-015021-pol2qm74	6992	13	fullthickness	fullthickness	JJ
cord-015021-pol2qm74	6992	14	dorsal	dorsal	NNP
cord-015021-pol2qm74	6992	15	burns	burn	NNS
cord-015021-pol2qm74	6992	16	&	&	CC
cord-015021-pol2qm74	6992	17	were	be	VBD
cord-015021-pol2qm74	6992	18	resuscitated	resuscitate	VBN
cord-015021-pol2qm74	6992	19	with	with	IN
cord-015021-pol2qm74	6992	20	2	2	CD
cord-015021-pol2qm74	6992	21	cc	cc	NN
cord-015021-pol2qm74	6992	22	ip	ip	NN
cord-015021-pol2qm74	6992	23	saline	saline	NN
cord-015021-pol2qm74	6992	24	.	.	.
cord-015021-pol2qm74	6993	1	Diets	diet	NNS
cord-015021-pol2qm74	6993	2	were	be	VBD
cord-015021-pol2qm74	6993	3	allowed	allow	VBN
cord-015021-pol2qm74	6993	4	ad	ad	NN
cord-015021-pol2qm74	6993	5	lib	lib	NN
cord-015021-pol2qm74	6993	6	;	;	:
cord-015021-pol2qm74	6993	7	caloric	caloric	JJ
cord-015021-pol2qm74	6993	8	intakes	intake	NNS
cord-015021-pol2qm74	6993	9	were	be	VBD
cord-015021-pol2qm74	6993	10	comparable	comparable	JJ
cord-015021-pol2qm74	6993	11	in	in	IN
cord-015021-pol2qm74	6993	12	all	all	DT
cord-015021-pol2qm74	6993	13	Gps	Gps	NNP
cord-015021-pol2qm74	6993	14	except	except	IN
cord-015021-pol2qm74	6993	15	fasted	fast	VBN
cord-015021-pol2qm74	6993	16	Gp	Gp	NNP
cord-015021-pol2qm74	6993	17	(	(	-LRB-
cord-015021-pol2qm74	6993	18	fast	fast	JJ
cord-015021-pol2qm74	6993	19	24	24	CD
cord-015021-pol2qm74	6993	20	hrs	hrs	NN
cord-015021-pol2qm74	6993	21	,	,	,
cord-015021-pol2qm74	6993	22	Chow	Chow	NNP
cord-015021-pol2qm74	6993	23	24	24	CD
cord-015021-pol2qm74	6993	24	hrs	hrs	NN
cord-015021-pol2qm74	6993	25	)	)	-RRB-
cord-015021-pol2qm74	6993	26	.	.	.
cord-015021-pol2qm74	6994	1	At	at	IN
cord-015021-pol2qm74	6994	2	48	48	CD
cord-015021-pol2qm74	6994	3	hrs	hrs	NN
cord-015021-pol2qm74	6994	4	postburn	postburn	NN
cord-015021-pol2qm74	6994	5	MLN	MLN	NNP
cord-015021-pol2qm74	6994	6	were	be	VBD
cord-015021-pol2qm74	6994	7	sterily	sterily	RB
cord-015021-pol2qm74	6994	8	removed	remove	VBN
cord-015021-pol2qm74	6994	9	,	,	,
cord-015021-pol2qm74	6994	10	homogenized	homogenize	VBN
cord-015021-pol2qm74	6994	11	and	and	CC
cord-015021-pol2qm74	6994	12	plated	plate	VBN
cord-015021-pol2qm74	6994	13	on	on	IN
cord-015021-pol2qm74	6994	14	heart	heart	NN
cord-015021-pol2qm74	6994	15	brain	brain	NN
cord-015021-pol2qm74	6994	16	infusion	infusion	NN
cord-015021-pol2qm74	6994	17	agar	agar	NN
cord-015021-pol2qm74	6994	18	;	;	:
cord-015021-pol2qm74	6994	19	CFU	CFU	NNP
cord-015021-pol2qm74	6994	20	/	/	SYM
cord-015021-pol2qm74	6994	21	g	g	NN
cord-015021-pol2qm74	6994	22	MLN	mln	NN
cord-015021-pol2qm74	6994	23	tissue	tissue	NN
cord-015021-pol2qm74	6994	24	were	be	VBD
cord-015021-pol2qm74	6994	25	determined	determine	VBN
cord-015021-pol2qm74	6994	26	.	.	.
cord-015021-pol2qm74	6995	1	BT	BT	NNP
cord-015021-pol2qm74	6995	2	was	be	VBD
cord-015021-pol2qm74	6995	3	analyzed	analyze	VBN
cord-015021-pol2qm74	6995	4	by	by	IN
cord-015021-pol2qm74	6995	5	Fishers	Fishers	NNPS
cord-015021-pol2qm74	6995	6	Exact	Exact	NNP
cord-015021-pol2qm74	6995	7	Test	Test	NNP
cord-015021-pol2qm74	6995	8	,	,	,
cord-015021-pol2qm74	6995	9	CFU	CFU	NNP
cord-015021-pol2qm74	6995	10	/	/	SYM
cord-015021-pol2qm74	6995	11	g	g	NN
cord-015021-pol2qm74	6995	12	by	by	IN
cord-015021-pol2qm74	6995	13	ANOVA	ANOVA	NNP
cord-015021-pol2qm74	6995	14	-	-	HYPH
cord-015021-pol2qm74	6995	15	Bonferroni	Bonferroni	NNP
cord-015021-pol2qm74	6995	16	.	.	.
cord-015021-pol2qm74	6996	1	*	*	NFP
cord-015021-pol2qm74	6996	2	P<0.01	P<0.01	NNS
cord-015021-pol2qm74	6996	3	,	,	.
cord-015021-pol2qm74	6997	1	*	*	NFP
cord-015021-pol2qm74	6997	2	*	*	NFP
cord-015021-pol2qm74	6997	3	P<0.05	P<0.05	NNS
cord-015021-pol2qm74	6997	4	compared	compare	VBN
cord-015021-pol2qm74	6997	5	to	to	IN
cord-015021-pol2qm74	6997	6	IMP	IMP	NNP
cord-015021-pol2qm74	6997	7	and	and	CC
cord-015021-pol2qm74	6997	8	Burn	burn	VB
cord-015021-pol2qm74	6997	9	-	-	HYPH
cord-015021-pol2qm74	6997	10	Fast	Fast	NNP
cord-015021-pol2qm74	6997	11	Gps	Gps	NNP
cord-015021-pol2qm74	6997	12	.	.	.
cord-015021-pol2qm74	6998	1	Background	background	NN
cord-015021-pol2qm74	6998	2	.	.	.
cord-015021-pol2qm74	6999	1	Infectious	infectious	JJ
cord-015021-pol2qm74	6999	2	complications	complication	NNS
cord-015021-pol2qm74	6999	3	following	follow	VBG
cord-015021-pol2qm74	6999	4	trauma	trauma	NN
cord-015021-pol2qm74	6999	5	,	,	,
cord-015021-pol2qm74	6999	6	major	major	JJ
cord-015021-pol2qm74	6999	7	operation	operation	NN
cord-015021-pol2qm74	6999	8	,	,	,
cord-015021-pol2qm74	6999	9	or	or	CC
cord-015021-pol2qm74	6999	10	critical	critical	JJ
cord-015021-pol2qm74	6999	11	illness	illness	NN
cord-015021-pol2qm74	6999	12	adversely	adversely	RB
cord-015021-pol2qm74	6999	13	affect	affect	VBP
cord-015021-pol2qm74	6999	14	hospital	hospital	NN
cord-015021-pol2qm74	6999	15	cost	cost	NN
cord-015021-pol2qm74	6999	16	and	and	CC
cord-015021-pol2qm74	6999	17	length	length	NN
cord-015021-pol2qm74	6999	18	of	of	IN
cord-015021-pol2qm74	6999	19	stay	stay	NN
cord-015021-pol2qm74	6999	20	(	(	-LRB-
cord-015021-pol2qm74	6999	21	LOS	LOS	NNP
cord-015021-pol2qm74	6999	22	)	)	-RRB-
cord-015021-pol2qm74	6999	23	.	.	.
cord-015021-pol2qm74	7000	1	Some	some	DT
cord-015021-pol2qm74	7000	2	key	key	JJ
cord-015021-pol2qm74	7000	3	nutrients	nutrient	NNS
cord-015021-pol2qm74	7000	4	have	have	VBP
cord-015021-pol2qm74	7000	5	been	be	VBN
cord-015021-pol2qm74	7000	6	shown	show	VBN
cord-015021-pol2qm74	7000	7	to	to	TO
cord-015021-pol2qm74	7000	8	possess	possess	VB
cord-015021-pol2qm74	7000	9	immune	immune	JJ
cord-015021-pol2qm74	7000	10	enhancing	enhance	VBG
cord-015021-pol2qm74	7000	11	properties	property	NNS
cord-015021-pol2qm74	7000	12	.	.	.
cord-015021-pol2qm74	7001	1	This	this	DT
cord-015021-pol2qm74	7001	2	multicenter	multicenter	JJ
cord-015021-pol2qm74	7001	3	trial	trial	NN
cord-015021-pol2qm74	7001	4	was	be	VBD
cord-015021-pol2qm74	7001	5	conducted	conduct	VBN
cord-015021-pol2qm74	7001	6	to	to	TO
cord-015021-pol2qm74	7001	7	determine	determine	VB
cord-015021-pol2qm74	7001	8	if	if	IN
cord-015021-pol2qm74	7001	9	early	early	JJ
cord-015021-pol2qm74	7001	10	administration	administration	NN
cord-015021-pol2qm74	7001	11	of	of	IN
cord-015021-pol2qm74	7001	12	an	an	DT
cord-015021-pol2qm74	7001	13	enteral	enteral	JJ
cord-015021-pol2qm74	7001	14	formula	formula	NN
cord-015021-pol2qm74	7001	15	supplemented	supplement	VBN
cord-015021-pol2qm74	7001	16	with	with	IN
cord-015021-pol2qm74	7001	17	arginine	arginine	NN
cord-015021-pol2qm74	7001	18	,	,	,
cord-015021-pol2qm74	7001	19	dietary	dietary	JJ
cord-015021-pol2qm74	7001	20	nucleotides	nucleotide	NNS
cord-015021-pol2qm74	7001	21	and	and	CC
cord-015021-pol2qm74	7001	22	fish	fish	NN
cord-015021-pol2qm74	7001	23	oil	oil	NN
cord-015021-pol2qm74	7001	24	can	can	MD
cord-015021-pol2qm74	7001	25	decrease	decrease	VB
cord-015021-pol2qm74	7001	26	LOS	LOS	NNP
cord-015021-pol2qm74	7001	27	and	and	CC
cord-015021-pol2qm74	7001	28	infectious	infectious	JJ
cord-015021-pol2qm74	7001	29	complications	complication	NNS
cord-015021-pol2qm74	7001	30	in	in	IN
cord-015021-pol2qm74	7001	31	ICU	ICU	NNP
cord-015021-pol2qm74	7001	32	patients	patient	NNS
cord-015021-pol2qm74	7001	33	.	.	.
cord-015021-pol2qm74	7002	1	Methods	method	NNS
cord-015021-pol2qm74	7002	2	.	.	.
cord-015021-pol2qm74	7003	1	This	this	DT
cord-015021-pol2qm74	7003	2	was	be	VBD
cord-015021-pol2qm74	7003	3	a	a	DT
cord-015021-pol2qm74	7003	4	prospective	prospective	JJ
cord-015021-pol2qm74	7003	5	,	,	,
cord-015021-pol2qm74	7003	6	randomized	randomized	JJ
cord-015021-pol2qm74	7003	7	,	,	,
cord-015021-pol2qm74	7003	8	double	double	JJ
cord-015021-pol2qm74	7003	9	-	-	HYPH
cord-015021-pol2qm74	7003	10	blind	blind	JJ
cord-015021-pol2qm74	7003	11	study	study	NN
cord-015021-pol2qm74	7003	12	of	of	IN
cord-015021-pol2qm74	7003	13	326	326	CD
cord-015021-pol2qm74	7003	14	adult	adult	NN
cord-015021-pol2qm74	7003	15	ICU	ICU	NNP
cord-015021-pol2qm74	7003	16	patients	patient	NNS
cord-015021-pol2qm74	7003	17	who	who	WP
cord-015021-pol2qm74	7003	18	required	require	VBD
cord-015021-pol2qm74	7003	19	enteral	enteral	NN
cord-015021-pol2qm74	7003	20	feeding	feed	VBG
cord-015021-pol2qm74	7003	21	for	for	IN
cord-015021-pol2qm74	7003	22	>	>	$
cord-015021-pol2qm74	7003	23	7	7	CD
cord-015021-pol2qm74	7003	24	days	day	NNS
cord-015021-pol2qm74	7003	25	.	.	.
cord-015021-pol2qm74	7004	1	Patients	patient	NNS
cord-015021-pol2qm74	7004	2	entered	enter	VBD
cord-015021-pol2qm74	7004	3	the	the	DT
cord-015021-pol2qm74	7004	4	study	study	NN
cord-015021-pol2qm74	7004	5	within	within	IN
cord-015021-pol2qm74	7004	6	48	48	CD
cord-015021-pol2qm74	7004	7	hr	hr	NN
cord-015021-pol2qm74	7004	8	of	of	IN
cord-015021-pol2qm74	7004	9	the	the	DT
cord-015021-pol2qm74	7004	10	event	event	NN
cord-015021-pol2qm74	7004	11	,	,	,
cord-015021-pol2qm74	7004	12	were	be	VBD
cord-015021-pol2qm74	7004	13	stratified	stratify	VBN
cord-015021-pol2qm74	7004	14	by	by	IN
cord-015021-pol2qm74	7004	15	age	age	NN
cord-015021-pol2qm74	7004	16	and	and	CC
cord-015021-pol2qm74	7004	17	disease	disease	NN
cord-015021-pol2qm74	7004	18	,	,	,
cord-015021-pol2qm74	7004	19	and	and	CC
cord-015021-pol2qm74	7004	20	were	be	VBD
cord-015021-pol2qm74	7004	21	randomized	randomize	VBN
cord-015021-pol2qm74	7004	22	to	to	TO
cord-015021-pol2qm74	7004	23	receive	receive	VB
cord-015021-pol2qm74	7004	24	either	either	CC
cord-015021-pol2qm74	7004	25	the	the	DT
cord-015021-pol2qm74	7004	26	supplemented	supplement	VBN
cord-015021-pol2qm74	7004	27	formula	formula	NN
cord-015021-pol2qm74	7004	28	(	(	-LRB-
cord-015021-pol2qm74	7004	29	IMPACT	IMPACT	NNP
cord-015021-pol2qm74	7004	30	®	®	NNPS
cord-015021-pol2qm74	7004	31	)	)	-RRB-
cord-015021-pol2qm74	7004	32	or	or	CC
cord-015021-pol2qm74	7004	33	the	the	DT
cord-015021-pol2qm74	7004	34	conventional	conventional	JJ
cord-015021-pol2qm74	7004	35	formula	formula	NN
cord-015021-pol2qm74	7004	36	(	(	-LRB-
cord-015021-pol2qm74	7004	37	Osmolite	Osmolite	NNP
cord-015021-pol2qm74	7004	38	®	®	NN
cord-015021-pol2qm74	7004	39	HN	HN	NNP
cord-015021-pol2qm74	7004	40	)	)	-RRB-
cord-015021-pol2qm74	7004	41	.	.	.
cord-015021-pol2qm74	7005	1	Feedings	feeding	NNS
cord-015021-pol2qm74	7005	2	were	be	VBD
cord-015021-pol2qm74	7005	3	initiated	initiate	VBN
cord-015021-pol2qm74	7005	4	at	at	IN
cord-015021-pol2qm74	7005	5	full	full	JJ
cord-015021-pol2qm74	7005	6	strength	strength	NN
cord-015021-pol2qm74	7005	7	and	and	CC
cord-015021-pol2qm74	7005	8	advanced	advance	VBD
cord-015021-pol2qm74	7005	9	to	to	IN
cord-015021-pol2qm74	7005	10	at	at	RB
cord-015021-pol2qm74	7005	11	least	least	RBS
cord-015021-pol2qm74	7005	12	60	60	CD
cord-015021-pol2qm74	7005	13	ml	ml	NN
cord-015021-pol2qm74	7005	14	/	/	SYM
cord-015021-pol2qm74	7005	15	hr	hr	NN
cord-015021-pol2qm74	7005	16	by	by	IN
cord-015021-pol2qm74	7005	17	96	96	CD
cord-015021-pol2qm74	7005	18	hr	hr	NN
cord-015021-pol2qm74	7005	19	after	after	IN
cord-015021-pol2qm74	7005	20	event	event	NN
cord-015021-pol2qm74	7005	21	.	.	.
cord-015021-pol2qm74	7006	1	Results	result	NNS
cord-015021-pol2qm74	7006	2	.	.	.
cord-015021-pol2qm74	7007	1	Both	both	DT
cord-015021-pol2qm74	7007	2	groups	group	NNS
cord-015021-pol2qm74	7007	3	tolerated	tolerate	VBD
cord-015021-pol2qm74	7007	4	administration	administration	NN
cord-015021-pol2qm74	7007	5	of	of	IN
cord-015021-pol2qm74	7007	6	formula	formula	NNP
cord-015021-pol2qm74	7007	7	well	well	RB
cord-015021-pol2qm74	7007	8	.	.	.
cord-015021-pol2qm74	7008	1	For	for	IN
cord-015021-pol2qm74	7008	2	patients	patient	NNS
cord-015021-pol2qm74	7008	3	fed	feed	VBN
cord-015021-pol2qm74	7008	4	>	>	XX
cord-015021-pol2qm74	7008	5	7	7	CD
cord-015021-pol2qm74	7008	6	days	day	NNS
cord-015021-pol2qm74	7008	7	,	,	,
cord-015021-pol2qm74	7008	8	the	the	DT
cord-015021-pol2qm74	7008	9	median	median	JJ
cord-015021-pol2qm74	7008	10	LOS	LOS	NNP
cord-015021-pol2qm74	7008	11	was	be	VBD
cord-015021-pol2qm74	7008	12	25	25	CD
cord-015021-pol2qm74	7008	13	%	%	NN
cord-015021-pol2qm74	7008	14	shorter	short	JJR
cord-015021-pol2qm74	7009	1	(	(	-LRB-
cord-015021-pol2qm74	7009	2	p	p	NN
cord-015021-pol2qm74	7009	3	=	=	SYM
cord-015021-pol2qm74	7009	4	O.OL	O.OL	NNP
cord-015021-pol2qm74	7009	5	)	)	-RRB-
cord-015021-pol2qm74	7009	6	for	for	IN
cord-015021-pol2qm74	7009	7	the	the	DT
cord-015021-pol2qm74	7009	8	--	--	:
cord-015021-pol2qm74	7009	9	supplemented	supplement	VBN
cord-015021-pol2qm74	7009	10	group	group	NN
cord-015021-pol2qm74	7009	11	(	(	-LRB-
cord-015021-pol2qm74	7009	12	21	21	CD
cord-015021-pol2qm74	7009	13	days	day	NNS
cord-015021-pol2qm74	7009	14	)	)	-RRB-
cord-015021-pol2qm74	7010	1	compared	compare	VBN
cord-015021-pol2qm74	7010	2	to	to	IN
cord-015021-pol2qm74	7010	3	the	the	DT
cord-015021-pol2qm74	7010	4	conventional	conventional	JJ
cord-015021-pol2qm74	7010	5	group	group	NN
cord-015021-pol2qm74	7010	6	(	(	-LRB-
cord-015021-pol2qm74	7010	7	28	28	CD
cord-015021-pol2qm74	7010	8	days	day	NNS
cord-015021-pol2qm74	7010	9	)	)	-RRB-
cord-015021-pol2qm74	7010	10	.	.	.
cord-015021-pol2qm74	7011	1	The	the	DT
cord-015021-pol2qm74	7011	2	incidence	incidence	NN
cord-015021-pol2qm74	7011	3	of	of	IN
cord-015021-pol2qm74	7011	4	most	most	JJS
cord-015021-pol2qm74	7011	5	infectious	infectious	JJ
cord-015021-pol2qm74	7011	6	complications	complication	NNS
cord-015021-pol2qm74	7011	7	was	be	VBD
cord-015021-pol2qm74	7011	8	lower	low	JJR
cord-015021-pol2qm74	7011	9	in	in	IN
cord-015021-pol2qm74	7011	10	the	the	DT
cord-015021-pol2qm74	7011	11	supplemented	supplement	VBN
cord-015021-pol2qm74	7011	12	group	group	NN
cord-015021-pol2qm74	7011	13	,	,	,
cord-015021-pol2qm74	7011	14	but	but	CC
cord-015021-pol2qm74	7011	15	this	this	DT
cord-015021-pol2qm74	7011	16	difference	difference	NN
cord-015021-pol2qm74	7011	17	reached	reach	VBD
cord-015021-pol2qm74	7011	18	significance	significance	NN
cord-015021-pol2qm74	7011	19	only	only	RB
cord-015021-pol2qm74	7011	20	for	for	IN
cord-015021-pol2qm74	7011	21	urinary	urinary	JJ
cord-015021-pol2qm74	7011	22	tract	tract	NN
cord-015021-pol2qm74	7011	23	infections	infection	NNS
cord-015021-pol2qm74	7012	1	(	(	-LRB-
cord-015021-pol2qm74	7012	2	p	p	NN
cord-015021-pol2qm74	7012	3	=	=	SYM
cord-015021-pol2qm74	7012	4	O.O05	o.o05	NN
cord-015021-pol2qm74	7012	5	)	)	-RRB-
cord-015021-pol2qm74	7012	6	.	.	.
cord-015021-pol2qm74	7013	1	The	the	DT
cord-015021-pol2qm74	7013	2	supplemented	supplemented	JJ
cord-015021-pol2qm74	7013	3	group	group	NN
cord-015021-pol2qm74	7013	4	had	have	VBD
cord-015021-pol2qm74	7013	5	a	a	DT
cord-015021-pol2qm74	7013	6	significantly	significantly	RB
cord-015021-pol2qm74	7013	7	shorter	short	JJR
cord-015021-pol2qm74	7013	8	LOS	LOS	NNP
cord-015021-pol2qm74	7013	9	from	from	IN
cord-015021-pol2qm74	7013	10	onset	onset	NN
cord-015021-pol2qm74	7013	11	of	of	IN
cord-015021-pol2qm74	7013	12	infectious	infectious	JJ
cord-015021-pol2qm74	7013	13	complication	complication	NN
cord-015021-pol2qm74	7013	14	until	until	IN
cord-015021-pol2qm74	7013	15	discharge	discharge	NN
cord-015021-pol2qm74	7013	16	for	for	IN
cord-015021-pol2qm74	7013	17	patients	patient	NNS
cord-015021-pol2qm74	7013	18	with	with	IN
cord-015021-pol2qm74	7013	19	pneumonia	pneumonia	NN
cord-015021-pol2qm74	7013	20	(	(	-LRB-
cord-015021-pol2qm74	7013	21	19	19	CD
cord-015021-pol2qm74	7013	22	vs.	vs.	IN
cord-015021-pol2qm74	7013	23	27	27	CD
cord-015021-pol2qm74	7013	24	days	day	NNS
cord-015021-pol2qm74	7013	25	)	)	-RRB-
cord-015021-pol2qm74	7013	26	and	and	CC
cord-015021-pol2qm74	7013	27	skin	skin	NN
cord-015021-pol2qm74	7013	28	/	/	SYM
cord-015021-pol2qm74	7013	29	soft	soft	JJ
cord-015021-pol2qm74	7013	30	tissue	tissue	NN
cord-015021-pol2qm74	7013	31	infection	infection	NN
cord-015021-pol2qm74	7013	32	(	(	-LRB-
cord-015021-pol2qm74	7013	33	19	19	CD
cord-015021-pol2qm74	7013	34	vs.	vs.	NN
cord-015021-pol2qm74	7013	35	37	37	CD
cord-015021-pol2qm74	7013	36	days	day	NNS
cord-015021-pol2qm74	7013	37	)	)	-RRB-
cord-015021-pol2qm74	7013	38	.	.	.
cord-015021-pol2qm74	7014	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	7014	2	.	.	.
cord-015021-pol2qm74	7015	1	Administration	administration	NN
cord-015021-pol2qm74	7015	2	of	of	IN
cord-015021-pol2qm74	7015	3	the	the	DT
cord-015021-pol2qm74	7015	4	supplemented	supplement	VBN
cord-015021-pol2qm74	7015	5	formula	formula	NN
cord-015021-pol2qm74	7015	6	was	be	VBD
cord-015021-pol2qm74	7015	7	safe	safe	JJ
cord-015021-pol2qm74	7015	8	and	and	CC
cord-015021-pol2qm74	7015	9	well	well	RB
cord-015021-pol2qm74	7015	10	tolerated	tolerate	VBN
cord-015021-pol2qm74	7015	11	.	.	.
cord-015021-pol2qm74	7016	1	When	when	WRB
cord-015021-pol2qm74	7016	2	fed	fed	NNP
cord-015021-pol2qm74	7016	3	>	>	XX
cord-015021-pol2qm74	7016	4	7	7	CD
cord-015021-pol2qm74	7016	5	days	day	NNS
cord-015021-pol2qm74	7016	6	,	,	,
cord-015021-pol2qm74	7016	7	it	-PRON-	PRP
cord-015021-pol2qm74	7016	8	reduced	reduce	VBD
cord-015021-pol2qm74	7016	9	the	the	DT
cord-015021-pol2qm74	7016	10	incidence	incidence	NN
cord-015021-pol2qm74	7016	11	of	of	IN
cord-015021-pol2qm74	7016	12	most	most	JJS
cord-015021-pol2qm74	7016	13	infectious	infectious	JJ
cord-015021-pol2qm74	7016	14	complications	complication	NNS
cord-015021-pol2qm74	7016	15	,	,	,
cord-015021-pol2qm74	7016	16	and	and	CC
cord-015021-pol2qm74	7016	17	significantly	significantly	RB
cord-015021-pol2qm74	7016	18	reduced	reduce	VBN
cord-015021-pol2qm74	7016	19	LOS	LOS	NNP
cord-015021-pol2qm74	7016	20	.	.	.
cord-015021-pol2qm74	7017	1	Materials	material	NNS
cord-015021-pol2qm74	7017	2	and	and	CC
cord-015021-pol2qm74	7017	3	Methods	method	NNS
cord-015021-pol2qm74	7017	4	:	:	:
cord-015021-pol2qm74	7017	5	Twenty	twenty	CD
cord-015021-pol2qm74	7017	6	-	-	HYPH
cord-015021-pol2qm74	7017	7	seven	seven	CD
cord-015021-pol2qm74	7017	8	patients	patient	NNS
cord-015021-pol2qm74	7017	9	were	be	VBD
cord-015021-pol2qm74	7017	10	randomised	randomise	VBN
cord-015021-pol2qm74	7017	11	into	into	IN
cord-015021-pol2qm74	7017	12	3	3	CD
cord-015021-pol2qm74	7017	13	groups	group	NNS
cord-015021-pol2qm74	7017	14	(	(	-LRB-
cord-015021-pol2qm74	7017	15	n=	n=	NNP
cord-015021-pol2qm74	7017	16	9	9	CD
cord-015021-pol2qm74	7017	17	each	each	DT
cord-015021-pol2qm74	7017	18	)	)	-RRB-
cord-015021-pol2qm74	7017	19	to	to	TO
cord-015021-pol2qm74	7017	20	receive	receive	VB
cord-015021-pol2qm74	7017	21	either	either	CC
cord-015021-pol2qm74	7017	22	a	a	DT
cord-015021-pol2qm74	7017	23	standard	standard	JJ
cord-015021-pol2qm74	7017	24	enteral	enteral	JJ
cord-015021-pol2qm74	7017	25	formula	formula	NN
cord-015021-pol2qm74	7017	26	,	,	,
cord-015021-pol2qm74	7017	27	the	the	DT
cord-015021-pol2qm74	7017	28	same	same	JJ
cord-015021-pol2qm74	7017	29	formula	formula	NN
cord-015021-pol2qm74	7017	30	enriched	enrich	VBN
cord-015021-pol2qm74	7017	31	with	with	IN
cord-015021-pol2qm74	7017	32	arginine	arginine	NN
cord-015021-pol2qm74	7017	33	,	,	,
cord-015021-pol2qm74	7017	34	RNA	RNA	NNP
cord-015021-pol2qm74	7017	35	and	and	CC
cord-015021-pol2qm74	7017	36	omega	omega	NN
cord-015021-pol2qm74	7017	37	3	3	CD
cord-015021-pol2qm74	7017	38	fatty	fatty	JJ
cord-015021-pol2qm74	7017	39	acids	acid	NNS
cord-015021-pol2qm74	7017	40	(	(	-LRB-
cord-015021-pol2qm74	7017	41	enriched	enrich	VBN
cord-015021-pol2qm74	7017	42	group	group	NN
cord-015021-pol2qm74	7017	43	)	)	-RRB-
cord-015021-pol2qm74	7017	44	or	or	CC
cord-015021-pol2qm74	7017	45	isonitrogen	isonitrogen	NNP
cord-015021-pol2qm74	7017	46	,	,	,
cord-015021-pol2qm74	7017	47	isocaloric	isocaloric	JJ
cord-015021-pol2qm74	7017	48	parenteral	parenteral	JJ
cord-015021-pol2qm74	7017	49	nutrition	nutrition	NN
cord-015021-pol2qm74	7017	50	.	.	.
cord-015021-pol2qm74	7018	1	Early	early	JJ
cord-015021-pol2qm74	7018	2	enteral	enteral	JJ
cord-015021-pol2qm74	7018	3	nutrition	nutrition	NN
cord-015021-pol2qm74	7018	4	was	be	VBD
cord-015021-pol2qm74	7018	5	started	start	VBN
cord-015021-pol2qm74	7018	6	within	within	IN
cord-015021-pol2qm74	7018	7	12	12	CD
cord-015021-pol2qm74	7018	8	hours	hour	NNS
cord-015021-pol2qm74	7018	9	following	follow	VBG
cord-015021-pol2qm74	7018	10	surgery	surgery	NN
cord-015021-pol2qm74	7018	11	(	(	-LRB-
cord-015021-pol2qm74	7018	12	10	10	CD
cord-015021-pol2qm74	7018	13	ml	ml	NN
cord-015021-pol2qm74	7018	14	/	/	SYM
cord-015021-pol2qm74	7018	15	hour	hour	NN
cord-015021-pol2qm74	7018	16	)	)	-RRB-
cord-015021-pol2qm74	7018	17	.	.	.
cord-015021-pol2qm74	7019	1	It	-PRON-	PRP
cord-015021-pol2qm74	7019	2	was	be	VBD
cord-015021-pol2qm74	7019	3	progressively	progressively	RB
cord-015021-pol2qm74	7019	4	increased	increase	VBN
cord-015021-pol2qm74	7019	5	reaching	reach	VBG
cord-015021-pol2qm74	7019	6	a	a	DT
cord-015021-pol2qm74	7019	7	full	full	JJ
cord-015021-pol2qm74	7019	8	regimen	regimen	NN
cord-015021-pol2qm74	7019	9	on	on	IN
cord-015021-pol2qm74	7019	10	day	day	NN
cord-015021-pol2qm74	7019	11	4	4	CD
cord-015021-pol2qm74	7019	12	.	.	.
cord-015021-pol2qm74	7020	1	On	on	IN
cord-015021-pol2qm74	7020	2	hospital	hospital	NN
cord-015021-pol2qm74	7020	3	admission	admission	NN
cord-015021-pol2qm74	7020	4	and	and	CC
cord-015021-pol2qm74	7020	5	on	on	IN
cord-015021-pol2qm74	7020	6	post	post	JJ
cord-015021-pol2qm74	7020	7	-	-	JJ
cord-015021-pol2qm74	7020	8	operative	operative	JJ
cord-015021-pol2qm74	7020	9	day	day	NN
cord-015021-pol2qm74	7020	10	1	1	CD
cord-015021-pol2qm74	7020	11	and	and	CC
cord-015021-pol2qm74	7020	12	8	8	CD
cord-015021-pol2qm74	7020	13	,	,	,
cord-015021-pol2qm74	7020	14	the	the	DT
cord-015021-pol2qm74	7020	15	following	follow	VBG
cord-015021-pol2qm74	7020	16	parameters	parameter	NNS
cord-015021-pol2qm74	7020	17	were	be	VBD
cord-015021-pol2qm74	7020	18	assessed	assess	VBN
cord-015021-pol2qm74	7020	19	:	:	:
cord-015021-pol2qm74	7020	20	serum	serum	NN
cord-015021-pol2qm74	7020	21	level	level	NN
cord-015021-pol2qm74	7020	22	of	of	IN
cord-015021-pol2qm74	7020	23	transferrin	transferrin	NN
cord-015021-pol2qm74	7020	24	,	,	,
cord-015021-pol2qm74	7020	25	albumin	albumin	NN
cord-015021-pol2qm74	7020	26	,	,	,
cord-015021-pol2qm74	7020	27	prealbumin	prealbumin	NNP
cord-015021-pol2qm74	7020	28	,	,	,
cord-015021-pol2qm74	7020	29	retiool	retiool	NN
cord-015021-pol2qm74	7020	30	binding	bind	VBG
cord-015021-pol2qm74	7020	31	protein	protein	NN
cord-015021-pol2qm74	7020	32	(	(	-LRB-
cord-015021-pol2qm74	7020	33	RBP	RBP	NNP
cord-015021-pol2qm74	7020	34	)	)	-RRB-
cord-015021-pol2qm74	7020	35	,	,	,
cord-015021-pol2qm74	7020	36	cholinesterase	cholinesterase	NN
cord-015021-pol2qm74	7020	37	.	.	.
cord-015021-pol2qm74	7021	1	Delayed	delayed	JJ
cord-015021-pol2qm74	7021	2	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	7021	3	response	response	NN
cord-015021-pol2qm74	7021	4	,	,	,
cord-015021-pol2qm74	7021	5	IgG	IgG	NNP
cord-015021-pol2qm74	7021	6	,	,	,
cord-015021-pol2qm74	7021	7	IgM	IgM	NNP
cord-015021-pol2qm74	7021	8	,	,	,
cord-015021-pol2qm74	7021	9	IgA	IgA	NNP
cord-015021-pol2qm74	7021	10	,	,	,
cord-015021-pol2qm74	7021	11	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	7021	12	subsets	subset	NNS
cord-015021-pol2qm74	7021	13	and	and	CC
cord-015021-pol2qm74	7021	14	monocyte	monocyte	JJ
cord-015021-pol2qm74	7021	15	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7021	16	ability	ability	NN
cord-015021-pol2qm74	7021	17	were	be	VBD
cord-015021-pol2qm74	7021	18	evaluated	evaluate	VBN
cord-015021-pol2qm74	7021	19	on	on	IN
cord-015021-pol2qm74	7021	20	admission	admission	NN
cord-015021-pol2qm74	7021	21	and	and	CC
cord-015021-pol2qm74	7021	22	on	on	IN
cord-015021-pol2qm74	7021	23	post	post	JJ
cord-015021-pol2qm74	7021	24	-	-	JJ
cord-015021-pol2qm74	7021	25	operative	operative	JJ
cord-015021-pol2qm74	7021	26	day	day	NN
cord-015021-pol2qm74	7021	27	1	1	CD
cord-015021-pol2qm74	7021	28	,	,	,
cord-015021-pol2qm74	7021	29	4	4	CD
cord-015021-pol2qm74	7021	30	,	,	,
cord-015021-pol2qm74	7021	31	8	8	CD
cord-015021-pol2qm74	7021	32	.	.	.
cord-015021-pol2qm74	7022	1	The	the	DT
cord-015021-pol2qm74	7022	2	three	three	CD
cord-015021-pol2qm74	7022	3	groups	group	NNS
cord-015021-pol2qm74	7022	4	were	be	VBD
cord-015021-pol2qm74	7022	5	comparable	comparable	JJ
cord-015021-pol2qm74	7022	6	for	for	IN
cord-015021-pol2qm74	7022	7	sex	sex	NN
cord-015021-pol2qm74	7022	8	,	,	,
cord-015021-pol2qm74	7022	9	age	age	NN
cord-015021-pol2qm74	7022	10	,	,	,
cord-015021-pol2qm74	7022	11	cancer	cancer	NN
cord-015021-pol2qm74	7022	12	stage	stage	NN
cord-015021-pol2qm74	7022	13	,	,	,
cord-015021-pol2qm74	7022	14	type	type	NN
cord-015021-pol2qm74	7022	15	and	and	CC
cord-015021-pol2qm74	7022	16	duration	duration	NN
cord-015021-pol2qm74	7022	17	of	of	IN
cord-015021-pol2qm74	7022	18	surgery	surgery	NN
cord-015021-pol2qm74	7022	19	,	,	,
cord-015021-pol2qm74	7022	20	intra	intra	JJ
cord-015021-pol2qm74	7022	21	-	-	JJ
cord-015021-pol2qm74	7022	22	operative	operative	JJ
cord-015021-pol2qm74	7022	23	blood	blood	NN
cord-015021-pol2qm74	7022	24	loss	loss	NN
cord-015021-pol2qm74	7022	25	and	and	CC
cord-015021-pol2qm74	7022	26	amount	amount	NN
cord-015021-pol2qm74	7022	27	of	of	IN
cord-015021-pol2qm74	7022	28	blood	blood	NN
cord-015021-pol2qm74	7022	29	transfused	transfuse	VBN
cord-015021-pol2qm74	7022	30	.	.	.
cord-015021-pol2qm74	7023	1	In	in	IN
cord-015021-pol2qm74	7023	2	all	all	DT
cord-015021-pol2qm74	7023	3	groups	group	NNS
cord-015021-pol2qm74	7023	4	a	a	DT
cord-015021-pol2qm74	7023	5	significant	significant	JJ
cord-015021-pol2qm74	7023	6	drop	drop	NN
cord-015021-pol2qm74	7023	7	in	in	IN
cord-015021-pol2qm74	7023	8	all	all	PDT
cord-015021-pol2qm74	7023	9	the	the	DT
cord-015021-pol2qm74	7023	10	nutritional	nutritional	JJ
cord-015021-pol2qm74	7023	11	and	and	CC
cord-015021-pol2qm74	7023	12	immunological	immunological	JJ
cord-015021-pol2qm74	7023	13	parameters	parameter	NNS
cord-015021-pol2qm74	7023	14	was	be	VBD
cord-015021-pol2qm74	7023	15	observed	observe	VBN
cord-015021-pol2qm74	7023	16	on	on	IN
cord-015021-pol2qm74	7023	17	postoperative	postoperative	JJ
cord-015021-pol2qm74	7023	18	day	day	NN
cord-015021-pol2qm74	7023	19	1	1	CD
cord-015021-pol2qm74	7023	20	.	.	.
cord-015021-pol2qm74	7024	1	Comparing	compare	VBG
cord-015021-pol2qm74	7024	2	post	post	JJ
cord-015021-pol2qm74	7024	3	-	-	JJ
cord-015021-pol2qm74	7024	4	operative	operative	JJ
cord-015021-pol2qm74	7024	5	day	day	NN
cord-015021-pol2qm74	7024	6	1	1	CD
cord-015021-pol2qm74	7024	7	versus	versus	IN
cord-015021-pol2qm74	7024	8	day	day	NN
cord-015021-pol2qm74	7024	9	8	8	CD
cord-015021-pol2qm74	7024	10	a	a	DT
cord-015021-pol2qm74	7024	11	significant	significant	JJ
cord-015021-pol2qm74	7024	12	increase	increase	NN
cord-015021-pol2qm74	7024	13	of	of	IN
cord-015021-pol2qm74	7024	14	prealbumin	prealbumin	NN
cord-015021-pol2qm74	7024	15	(	(	-LRB-
cord-015021-pol2qm74	7024	16	p<0.02	p<0.02	NN
cord-015021-pol2qm74	7024	17	)	)	-RRB-
cord-015021-pol2qm74	7024	18	and	and	CC
cord-015021-pol2qm74	7024	19	RBP	RBP	NNP
cord-015021-pol2qm74	7024	20	(	(	-LRB-
cord-015021-pol2qm74	7024	21	p<0.005	p<0.005	JJ
cord-015021-pol2qm74	7024	22	)	)	-RRB-
cord-015021-pol2qm74	7024	23	was	be	VBD
cord-015021-pol2qm74	7024	24	found	find	VBN
cord-015021-pol2qm74	7024	25	only	only	RB
cord-015021-pol2qm74	7024	26	in	in	IN
cord-015021-pol2qm74	7024	27	the	the	DT
cord-015021-pol2qm74	7024	28	enriched	enriched	JJ
cord-015021-pol2qm74	7024	29	group	group	NN
cord-015021-pol2qm74	7024	30	.	.	.
cord-015021-pol2qm74	7025	1	With	with	IN
cord-015021-pol2qm74	7025	2	respect	respect	NN
cord-015021-pol2qm74	7025	3	to	to	IN
cord-015021-pol2qm74	7025	4	immunological	immunological	JJ
cord-015021-pol2qm74	7025	5	variables	variable	NNS
cord-015021-pol2qm74	7025	6	an	an	DT
cord-015021-pol2qm74	7025	7	increased	increase	VBN
cord-015021-pol2qm74	7025	8	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7025	9	ability	ability	NN
cord-015021-pol2qm74	7025	10	(	(	-LRB-
cord-015021-pol2qm74	7025	11	p<0.001	p<0.001	CD
cord-015021-pol2qm74	7025	12	)	)	-RRB-
cord-015021-pol2qm74	7025	13	and	and	CC
cord-015021-pol2qm74	7025	14	a	a	DT
cord-015021-pol2qm74	7025	15	significant	significant	JJ
cord-015021-pol2qm74	7025	16	recovery	recovery	NN
cord-015021-pol2qm74	7025	17	in	in	IN
cord-015021-pol2qm74	7025	18	delayed	delay	VBN
cord-015021-pol2qm74	7025	19	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	7025	20	response	response	NN
cord-015021-pol2qm74	7025	21	(	(	-LRB-
cord-015021-pol2qm74	7025	22	p	p	NN
cord-015021-pol2qm74	7025	23	<	<	XX
cord-015021-pol2qm74	7025	24	0.005	0.005	CD
cord-015021-pol2qm74	7025	25	)	)	-RRB-
cord-015021-pol2qm74	7025	26	was	be	VBD
cord-015021-pol2qm74	7025	27	observed	observe	VBN
cord-015021-pol2qm74	7025	28	only	only	RB
cord-015021-pol2qm74	7025	29	in	in	IN
cord-015021-pol2qm74	7025	30	the	the	DT
cord-015021-pol2qm74	7025	31	enriched	enriched	JJ
cord-015021-pol2qm74	7025	32	group	group	NN
cord-015021-pol2qm74	7025	33	.	.	.
cord-015021-pol2qm74	7026	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	7026	2	:	:	:
cord-015021-pol2qm74	7027	1	These	these	DT
cord-015021-pol2qm74	7027	2	data	datum	NNS
cord-015021-pol2qm74	7027	3	are	be	VBP
cord-015021-pol2qm74	7027	4	suggestive	suggestive	JJ
cord-015021-pol2qm74	7027	5	for	for	IN
cord-015021-pol2qm74	7027	6	a	a	DT
cord-015021-pol2qm74	7027	7	more	more	RBR
cord-015021-pol2qm74	7027	8	effective	effective	JJ
cord-015021-pol2qm74	7027	9	post	post	JJ
cord-015021-pol2qm74	7027	10	-	-	JJ
cord-015021-pol2qm74	7027	11	operative	operative	JJ
cord-015021-pol2qm74	7027	12	recovery	recovery	NN
cord-015021-pol2qm74	7027	13	of	of	IN
cord-015021-pol2qm74	7027	14	both	both	DT
cord-015021-pol2qm74	7027	15	.	.	.
cord-015021-pol2qm74	7028	1	nutritional	nutritional	JJ
cord-015021-pol2qm74	7028	2	and	and	CC
cord-015021-pol2qm74	7028	3	immunological	immunological	JJ
cord-015021-pol2qm74	7028	4	status	status	NN
cord-015021-pol2qm74	7028	5	in	in	IN
cord-015021-pol2qm74	7028	6	cancer	cancer	NN
cord-015021-pol2qm74	7028	7	patients	patient	NNS
cord-015021-pol2qm74	7028	8	fed	feed	VBN
cord-015021-pol2qm74	7028	9	with	with	IN
cord-015021-pol2qm74	7028	10	enriched	enriched	JJ
cord-015021-pol2qm74	7028	11	enteral	enteral	NN
cord-015021-pol2qm74	7028	12	formula	formula	NN
cord-015021-pol2qm74	7028	13	.	.	.
cord-015021-pol2qm74	7029	1	Gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	7029	2	intolerance	intolerance	NN
cord-015021-pol2qm74	7029	3	was	be	VBD
cord-015021-pol2qm74	7029	4	equivalent	equivalent	JJ
cord-015021-pol2qm74	7029	5	(	(	-LRB-
cord-015021-pol2qm74	7029	6	18	18	CD
cord-015021-pol2qm74	7029	7	%	%	NN
cord-015021-pol2qm74	7029	8	in	in	IN
cord-015021-pol2qm74	7029	9	each	each	DT
cord-015021-pol2qm74	7029	10	group	group	NN
cord-015021-pol2qm74	7029	11	)	)	-RRB-
cord-015021-pol2qm74	7029	12	and	and	CC
cord-015021-pol2qm74	7029	13	laboratory	laboratory	NN
cord-015021-pol2qm74	7029	14	screening	screening	NN
cord-015021-pol2qm74	7029	15	confirmed	confirm	VBD
cord-015021-pol2qm74	7029	16	that	that	IN
cord-015021-pol2qm74	7029	17	both	both	DT
cord-015021-pol2qm74	7029	18	diets	diet	NNS
cord-015021-pol2qm74	7029	19	were	be	VBD
cord-015021-pol2qm74	7029	20	safe	safe	JJ
cord-015021-pol2qm74	7029	21	.	.	.
cord-015021-pol2qm74	7030	1	When	when	WRB
cord-015021-pol2qm74	7030	2	analyzing	analyze	VBG
cord-015021-pol2qm74	7030	3	clinical	clinical	JJ
cord-015021-pol2qm74	7030	4	outcome	outcome	NN
cord-015021-pol2qm74	7030	5	for	for	IN
cord-015021-pol2qm74	7030	6	all	all	DT
cord-015021-pol2qm74	7030	7	patients	patient	NNS
cord-015021-pol2qm74	7030	8	,	,	,
cord-015021-pol2qm74	7030	9	there	there	EX
cord-015021-pol2qm74	7030	10	were	be	VBD
cord-015021-pol2qm74	7030	11	no	no	DT
cord-015021-pol2qm74	7030	12	significant	significant	JJ
cord-015021-pol2qm74	7030	13	differences	difference	NNS
cord-015021-pol2qm74	7030	14	in	in	IN
cord-015021-pol2qm74	7030	15	septic	septic	JJ
cord-015021-pol2qm74	7030	16	complications	complication	NNS
cord-015021-pol2qm74	7030	17	(	(	-LRB-
cord-015021-pol2qm74	7030	18	Immun	Immun	NNP
cord-015021-pol2qm74	7030	19	-	-	HYPH
cord-015021-pol2qm74	7030	20	Aid	Aid	NNP
cord-015021-pol2qm74	7030	21	=	=	SYM
cord-015021-pol2qm74	7030	22	41	41	CD
cord-015021-pol2qm74	7030	23	%	%	NN
cord-015021-pol2qm74	7030	24	vs	vs	IN
cord-015021-pol2qm74	7030	25	Vivonex	Vivonex	NNP
cord-015021-pol2qm74	7030	26	TEN	TEN	NNP
cord-015021-pol2qm74	7030	27	=	=	SYM
cord-015021-pol2qm74	7030	28	35	35	CD
cord-015021-pol2qm74	7030	29	%	%	NN
cord-015021-pol2qm74	7030	30	)	)	-RRB-
cord-015021-pol2qm74	7030	31	,	,	,
cord-015021-pol2qm74	7030	32	mean	mean	VB
cord-015021-pol2qm74	7030	33	MOF	MOF	NNP
cord-015021-pol2qm74	7030	34	score	score	NN
cord-015021-pol2qm74	7030	35	(	(	-LRB-
cord-015021-pol2qm74	7030	36	Immun	Immun	NNP
cord-015021-pol2qm74	7030	37	-	-	HYPH
cord-015021-pol2qm74	7030	38	Aid	aid	NN
cord-015021-pol2qm74	7030	39	=	=	NFP
cord-015021-pol2qm74	7031	1	l.	l.	NNP
cord-015021-pol2qm74	7032	1	B	B	NNP
cord-015021-pol2qm74	7032	2	vs	vs	IN
cord-015021-pol2qm74	7032	3	Vivonex	Vivonex	NNP
cord-015021-pol2qm74	7032	4	TEN	TEN	NNP
cord-015021-pol2qm74	7032	5	=	=	SYM
cord-015021-pol2qm74	7032	6	3.6	3.6	CD
cord-015021-pol2qm74	7032	7	)	)	-RRB-
cord-015021-pol2qm74	7032	8	,	,	,
cord-015021-pol2qm74	7032	9	or	or	CC
cord-015021-pol2qm74	7032	10	mortality	mortality	NN
cord-015021-pol2qm74	7033	1	(	(	-LRB-
cord-015021-pol2qm74	7033	2	Immun	Immun	NNP
cord-015021-pol2qm74	7033	3	-	-	HYPH
cord-015021-pol2qm74	7033	4	Aid	aid	NN
cord-015021-pol2qm74	7033	5	0	0	CD
cord-015021-pol2qm74	7033	6	%	%	NN
cord-015021-pol2qm74	7033	7	vs	vs	IN
cord-015021-pol2qm74	7033	8	Vivonex	Vivonex	NNP
cord-015021-pol2qm74	7033	9	TEN	TEN	NNP
cord-015021-pol2qm74	7033	10	=	=	SYM
cord-015021-pol2qm74	7033	11	6	6	CD
cord-015021-pol2qm74	7033	12	%	%	NN
cord-015021-pol2qm74	7033	13	)	)	-RRB-
cord-015021-pol2qm74	7033	14	.	.	.
cord-015021-pol2qm74	7034	1	Kowever	Kowever	NNP
cord-015021-pol2qm74	7034	2	,	,	,
cord-015021-pol2qm74	7034	3	when	when	WRB
cord-015021-pol2qm74	7034	4	analyzing	analyze	VBG
cord-015021-pol2qm74	7034	5	the	the	DT
cord-015021-pol2qm74	7034	6	subgroup	subgroup	NN
cord-015021-pol2qm74	7034	7	of	of	IN
cord-015021-pol2qm74	7034	8	patients	patient	NNS
cord-015021-pol2qm74	7034	9	with	with	IN
cord-015021-pol2qm74	7034	10	severe	severe	JJ
cord-015021-pol2qm74	7034	11	injury	injury	NN
cord-015021-pol2qm74	7034	12	(	(	-LRB-
cord-015021-pol2qm74	7034	13	ISS	ISS	NNP
cord-015021-pol2qm74	7034	14	or	or	CC
cord-015021-pol2qm74	7035	1	ATI	ATI	NNP
cord-015021-pol2qm74	7035	2	_	_	NNP
cord-015021-pol2qm74	7036	1	>	>	XX
cord-015021-pol2qm74	7036	2	25	25	CD
cord-015021-pol2qm74	7036	3	)	)	-RRB-
cord-015021-pol2qm74	7036	4	,	,	,
cord-015021-pol2qm74	7036	5	patients	patient	NNS
cord-015021-pol2qm74	7036	6	receiving	receive	VBG
cord-015021-pol2qm74	7036	7	Immun	Immun	NNP
cord-015021-pol2qm74	7036	8	-	-	HYPH
cord-015021-pol2qm74	7036	9	Aid	Aid	NNP
cord-015021-pol2qm74	7036	10	appeared	appear	VBD
cord-015021-pol2qm74	7036	11	to	to	TO
cord-015021-pol2qm74	7036	12	have	have	VB
cord-015021-pol2qm74	7036	13	fewer	few	JJR
cord-015021-pol2qm74	7036	14	septic	septic	JJ
cord-015021-pol2qm74	7036	15	complications	complication	NNS
cord-015021-pol2qm74	7036	16	(	(	-LRB-
cord-015021-pol2qm74	7036	17	33	33	CD
cord-015021-pol2qm74	7036	18	%	%	NN
cord-015021-pol2qm74	7036	19	vs	vs	IN
cord-015021-pol2qm74	7036	20	50	50	CD
cord-015021-pol2qm74	7036	21	%	%	NN
cord-015021-pol2qm74	7036	22	)	)	-RRB-
cord-015021-pol2qm74	7036	23	and	and	CC
cord-015021-pol2qm74	7036	24	their	-PRON-	PRP$
cord-015021-pol2qm74	7036	25	mean	mean	JJ
cord-015021-pol2qm74	7036	26	MOF	MOF	NNP
cord-015021-pol2qm74	7036	27	was	be	VBD
cord-015021-pol2qm74	7036	28	significantly	significantly	RB
cord-015021-pol2qm74	7036	29	lower	low	JJR
cord-015021-pol2qm74	7036	30	(	(	-LRB-
cord-015021-pol2qm74	7037	1	1.8	1.8	CD
cord-015021-pol2qm74	7037	2	_	_	NN
cord-015021-pol2qm74	7037	3	+	+	CC
cord-015021-pol2qm74	7038	1	0.7	0.7	CD
cord-015021-pol2qm74	7038	2	vs	vs	IN
cord-015021-pol2qm74	7038	3	5.8	5.8	CD
cord-015021-pol2qm74	7038	4	+	+	SYM
cord-015021-pol2qm74	7038	5	1.7	1.7	CD
cord-015021-pol2qm74	7038	6	,	,	,
cord-015021-pol2qm74	7038	7	p	p	NN
cord-015021-pol2qm74	7038	8	=	=	SYM
cord-015021-pol2qm74	7038	9	0.05	0.05	CD
cord-015021-pol2qm74	7038	10	,	,	,
cord-015021-pol2qm74	7038	11	Student	Student	NNP
cord-015021-pol2qm74	7038	12	's	's	POS
cord-015021-pol2qm74	7038	13	t	t	NN
cord-015021-pol2qm74	7038	14	-	-	HYPH
cord-015021-pol2qm74	7038	15	test	test	NN
cord-015021-pol2qm74	7038	16	)	)	-RRB-
cord-015021-pol2qm74	7038	17	.	.	.
cord-015021-pol2qm74	7039	1	These	these	DT
cord-015021-pol2qm74	7039	2	preliminary	preliminary	JJ
cord-015021-pol2qm74	7039	3	data	datum	NNS
cord-015021-pol2qm74	7039	4	indicate	indicate	VBP
cord-015021-pol2qm74	7039	5	that	that	IN
cord-015021-pol2qm74	7039	6	Immun	Immun	NNP
cord-015021-pol2qm74	7039	7	-	-	HYPH
cord-015021-pol2qm74	7039	8	Aid	Aid	NNP
cord-015021-pol2qm74	7039	9	is	be	VBZ
cord-015021-pol2qm74	7039	10	tolerated	tolerate	VBN
cord-015021-pol2qm74	7039	11	well	well	RB
cord-015021-pol2qm74	7039	12	when	when	WRB
cord-015021-pol2qm74	7039	13	aggressively	aggressively	RB
cord-015021-pol2qm74	7039	14	delivered	deliver	VBN
cord-015021-pol2qm74	7039	15	immediately	immediately	RB
cord-015021-pol2qm74	7039	16	postinjury	postinjury	NNP
cord-015021-pol2qm74	7039	17	.	.	.
cord-015021-pol2qm74	7040	1	The	the	DT
cord-015021-pol2qm74	7040	2	ultimate	ultimate	JJ
cord-015021-pol2qm74	7040	3	affect	affect	NN
cord-015021-pol2qm74	7040	4	on	on	IN
cord-015021-pol2qm74	7040	5	clinical	clinical	JJ
cord-015021-pol2qm74	7040	6	outcome	outcome	NN
cord-015021-pol2qm74	7040	7	appears	appear	VBZ
cord-015021-pol2qm74	7040	8	~avorable	~avorable	NNP
cord-015021-pol2qm74	7040	9	for	for	IN
cord-015021-pol2qm74	7040	10	Immun	Immun	NNP
cord-015021-pol2qm74	7040	11	-	-	HYPH
cord-015021-pol2qm74	7040	12	Aid	Aid	NNP
cord-015021-pol2qm74	7040	13	,	,	,
cord-015021-pol2qm74	7040	14	but	but	CC
cord-015021-pol2qm74	7040	15	needs	need	VBZ
cord-015021-pol2qm74	7040	16	to	to	TO
cord-015021-pol2qm74	7040	17	be	be	VB
cord-015021-pol2qm74	7040	18	confirmed	confirm	VBN
cord-015021-pol2qm74	7040	19	in	in	IN
cord-015021-pol2qm74	7040	20	larger	large	JJR
cord-015021-pol2qm74	7040	21	patient	patient	NN
cord-015021-pol2qm74	7040	22	groups	group	NNS
cord-015021-pol2qm74	7040	23	.	.	.
cord-015021-pol2qm74	7041	1	Kemp?n	Kemp?n	NNP
cord-015021-pol2qm74	7041	2	,	,	,
cord-015021-pol2qm74	7041	3	M.	M.	NNP
cord-015021-pol2qm74	7041	4	,	,	,
cord-015021-pol2qm74	7041	5	Neumann	Neumann	NNP
cord-015021-pol2qm74	7041	6	,	,	,
cord-015021-pol2qm74	7041	7	H.A.	H.A.	NNP
cord-015021-pol2qm74	7041	8	,	,	,
cord-015021-pol2qm74	7042	1	He	-PRON-	PRP
cord-015021-pol2qm74	7042	2	I[michh	i[michh	NN
cord-015021-pol2qm74	7042	3	B	b	NN
cord-015021-pol2qm74	7042	4	:	:	:
cord-015021-pol2qm74	7042	5	As	as	IN
cord-015021-pol2qm74	7042	6	both	both	DT
cord-015021-pol2qm74	7042	7	increased	increase	VBN
cord-015021-pol2qm74	7042	8	,	,	,
cord-015021-pol2qm74	7042	9	normal	normal	JJ
cord-015021-pol2qm74	7042	10	and	and	CC
cord-015021-pol2qm74	7042	11	reduced	reduced	JJ
cord-015021-pol2qm74	7042	12	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7042	13	capabilities	capability	NNS
cord-015021-pol2qm74	7042	14	of	of	IN
cord-015021-pol2qm74	7042	15	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	7042	16	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7042	17	(	(	-LRB-
cord-015021-pol2qm74	7042	18	PMN	PMN	NNP
cord-015021-pol2qm74	7042	19	)	)	-RRB-
cord-015021-pol2qm74	7042	20	and	and	CC
cord-015021-pol2qm74	7042	21	monocytes	monocyte	VBZ
cord-015021-pol2qm74	7042	22	in	in	IN
cord-015021-pol2qm74	7042	23	acute	acute	JJ
cord-015021-pol2qm74	7042	24	batterial	batterial	JJ
cord-015021-pol2qm74	7042	25	infections	infection	NNS
cord-015021-pol2qm74	7042	26	have	have	VBP
cord-015021-pol2qm74	7042	27	been	be	VBN
cord-015021-pol2qm74	7042	28	reported	report	VBN
cord-015021-pol2qm74	7042	29	,	,	,
cord-015021-pol2qm74	7042	30	the	the	DT
cord-015021-pol2qm74	7042	31	role	role	NN
cord-015021-pol2qm74	7042	32	of	of	IN
cord-015021-pol2qm74	7042	33	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	7042	34	in	in	IN
cord-015021-pol2qm74	7042	35	patients	patient	NNS
cord-015021-pol2qm74	7042	36	with	with	IN
cord-015021-pol2qm74	7042	37	severe	severe	JJ
cord-015021-pol2qm74	7042	38	sepsis	sepsis	NN
cord-015021-pol2qm74	7042	39	is	be	VBZ
cord-015021-pol2qm74	7042	40	less	less	RBR
cord-015021-pol2qm74	7042	41	clear	clear	JJ
cord-015021-pol2qm74	7042	42	.	.	.
cord-015021-pol2qm74	7043	1	We	-PRON-	PRP
cord-015021-pol2qm74	7043	2	examined	examine	VBD
cord-015021-pol2qm74	7043	3	PMN	PMN	NNP
cord-015021-pol2qm74	7043	4	and	and	CC
cord-015021-pol2qm74	7043	5	monocytes	monocyte	VBZ
cord-015021-pol2qm74	7043	6	from	from	IN
cord-015021-pol2qm74	7043	7	10	10	CD
cord-015021-pol2qm74	7043	8	patients	patient	NNS
cord-015021-pol2qm74	7043	9	in	in	IN
cord-015021-pol2qm74	7043	10	septic	septic	JJ
cord-015021-pol2qm74	7043	11	shock	shock	NN
cord-015021-pol2qm74	7043	12	and	and	CC
cord-015021-pol2qm74	7043	13	17	17	CD
cord-015021-pol2qm74	7043	14	heaiLhy	heaiLhy	NNP
cord-015021-pol2qm74	7043	15	votunteers	votunteer	NNS
cord-015021-pol2qm74	7043	16	for	for	IN
cord-015021-pol2qm74	7043	17	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7043	18	function	function	NN
cord-015021-pol2qm74	7043	19	.	.	.
cord-015021-pol2qm74	7044	1	Phagocytosis	Phagocytosis	NNP
cord-015021-pol2qm74	7044	2	was	be	VBD
cord-015021-pol2qm74	7044	3	determined	determine	VBN
cord-015021-pol2qm74	7044	4	by	by	IN
cord-015021-pol2qm74	7044	5	flow	flow	NN
cord-015021-pol2qm74	7044	6	cytometry	cytometry	NN
cord-015021-pol2qm74	7044	7	(	(	-LRB-
cord-015021-pol2qm74	7044	8	FACScan	FACScan	NNP
cord-015021-pol2qm74	7044	9	)	)	-RRB-
cord-015021-pol2qm74	7044	10	and	and	CC
cord-015021-pol2qm74	7044	11	was	be	VBD
cord-015021-pol2qm74	7044	12	measured	measure	VBN
cord-015021-pol2qm74	7044	13	by	by	IN
cord-015021-pol2qm74	7044	14	the	the	DT
cord-015021-pol2qm74	7044	15	ability	ability	NN
cord-015021-pol2qm74	7044	16	of	of	IN
cord-015021-pol2qm74	7044	17	PMN	PMN	NNP
cord-015021-pol2qm74	7044	18	and	and	CC
cord-015021-pol2qm74	7044	19	monocytes	monocyte	VBZ
cord-015021-pol2qm74	7044	20	to	to	TO
cord-015021-pol2qm74	7044	21	phagocytose	phagocytose	JJ
cord-015021-pol2qm74	7044	22	E.Coli	E.Coli	NNS
cord-015021-pol2qm74	7044	23	marked	mark	VBN
cord-015021-pol2qm74	7044	24	with	with	IN
cord-015021-pol2qm74	7044	25	fluorescent	fluorescent	JJ
cord-015021-pol2qm74	7044	26	antibodies	antibody	NNS
cord-015021-pol2qm74	7044	27	.	.	.
cord-015021-pol2qm74	7045	1	A	a	DT
cord-015021-pol2qm74	7045	2	septic	septic	JJ
cord-015021-pol2qm74	7045	3	shock	shock	NN
cord-015021-pol2qm74	7045	4	was	be	VBD
cord-015021-pol2qm74	7045	5	defined	define	VBN
cord-015021-pol2qm74	7045	6	by	by	IN
cord-015021-pol2qm74	7045	7	the	the	DT
cord-015021-pol2qm74	7045	8	presence	presence	NN
cord-015021-pol2qm74	7045	9	of	of	IN
cord-015021-pol2qm74	7045	10	a	a	DT
cord-015021-pol2qm74	7045	11	~ource	~ource	NNP
cord-015021-pol2qm74	7045	12	of	of	IN
cord-015021-pol2qm74	7045	13	i	i	NNP
cord-015021-pol2qm74	7045	14	,	,	,
cord-015021-pol2qm74	7045	15	nfoctiQn	nfoctiQn	NNP
cord-015021-pol2qm74	7045	16	with	with	IN
cord-015021-pol2qm74	7045	17	a	a	DT
cord-015021-pol2qm74	7045	18	known	know	VBN
cord-015021-pol2qm74	7045	19	bacteriology	bacteriology	NN
cord-015021-pol2qm74	7045	20	,	,	,
cord-015021-pol2qm74	7045	21	distinct	distinct	JJ
cord-015021-pol2qm74	7045	22	signs	sign	NNS
cord-015021-pol2qm74	7045	23	of	of	IN
cord-015021-pol2qm74	7045	24	a	a	DT
cord-015021-pol2qm74	7045	25	systemic	systemic	JJ
cord-015021-pol2qm74	7045	26	response	response	NN
cord-015021-pol2qm74	7045	27	and	and	CC
cord-015021-pol2qm74	7045	28	defined	define	VBN
cord-015021-pol2qm74	7045	29	minimum	minimum	JJ
cord-015021-pol2qm74	7045	30	scores	score	NNS
cord-015021-pol2qm74	7045	31	in	in	IN
cord-015021-pol2qm74	7045	32	3	3	CD
cord-015021-pol2qm74	7045	33	ICU	ICU	NNP
cord-015021-pol2qm74	7045	34	scoring	score	VBG
cord-015021-pol2qm74	7045	35	systems	system	NNS
cord-015021-pol2qm74	7045	36	indicating	indicate	VBG
cord-015021-pol2qm74	7045	37	the	the	DT
cord-015021-pol2qm74	7045	38	presence	presence	NN
cord-015021-pol2qm74	7045	39	of	of	IN
cord-015021-pol2qm74	7045	40	a	a	DT
cord-015021-pol2qm74	7045	41	multiple	multiple	JJ
cord-015021-pol2qm74	7045	42	organ	organ	NN
cord-015021-pol2qm74	7045	43	failure	failure	NN
cord-015021-pol2qm74	7045	44	.	.	.
cord-015021-pol2qm74	7046	1	Additionally	additionally	RB
cord-015021-pol2qm74	7046	2	we	-PRON-	PRP
cord-015021-pol2qm74	7046	3	examined	examine	VBD
cord-015021-pol2qm74	7046	4	how	how	WRB
cord-015021-pol2qm74	7046	5	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7046	6	is	be	VBZ
cord-015021-pol2qm74	7046	7	influenced	influence	VBN
cord-015021-pol2qm74	7046	8	when	when	WRB
cord-015021-pol2qm74	7046	9	a	a	DT
cord-015021-pol2qm74	7046	10	new	new	JJ
cord-015021-pol2qm74	7046	11	enteral	enteral	JJ
cord-015021-pol2qm74	7046	12	diet	diet	NN
cord-015021-pol2qm74	7046	13	formulation	formulation	NN
cord-015021-pol2qm74	7046	14	containing	contain	VBG
cord-015021-pol2qm74	7046	15	substrates	substrate	NNS
cord-015021-pol2qm74	7046	16	suggested	suggest	VBD
cord-015021-pol2qm74	7046	17	to	to	TO
cord-015021-pol2qm74	7046	18	improve	improve	VB
cord-015021-pol2qm74	7046	19	immune	immune	JJ
cord-015021-pol2qm74	7046	20	function	function	NN
cord-015021-pol2qm74	7046	21	or	or	CC
cord-015021-pol2qm74	7046	22	Arginine	arginine	NN
cord-015021-pol2qm74	7046	23	,	,	,
cord-015021-pol2qm74	7046	24	one	one	CD
cord-015021-pol2qm74	7046	25	of	of	IN
cord-015021-pol2qm74	7046	26	its	-PRON-	PRP$
cord-015021-pol2qm74	7046	27	major	major	JJ
cord-015021-pol2qm74	7046	28	compononts	componont	NNS
cord-015021-pol2qm74	7046	29	,	,	,
cord-015021-pol2qm74	7046	30	is	be	VBZ
cord-015021-pol2qm74	7046	31	added	add	VBN
cord-015021-pol2qm74	7046	32	in	in	IN
cord-015021-pol2qm74	7046	33	vitro	vitro	FW
cord-015021-pol2qm74	7046	34	in	in	IN
cord-015021-pol2qm74	7046	35	defined	define	VBN
cord-015021-pol2qm74	7046	36	concentrations	concentration	NNS
cord-015021-pol2qm74	7046	37	and	and	CC
cord-015021-pol2qm74	7046	38	incubated	incubate	VBN
cord-015021-pol2qm74	7046	39	for	for	IN
cord-015021-pol2qm74	7046	40	10	10	CD
cord-015021-pol2qm74	7046	41	minutes	minute	NNS
cord-015021-pol2qm74	7046	42	.	.	.
cord-015021-pol2qm74	7047	1	PMN	PMN	NNP
cord-015021-pol2qm74	7047	2	(	(	-LRB-
cord-015021-pol2qm74	7047	3	p{O,05	p{O,05	NNP
cord-015021-pol2qm74	7047	4	)	)	-RRB-
cord-015021-pol2qm74	7047	5	and	and	CC
cord-015021-pol2qm74	7047	6	monocytes	monocyte	NNS
cord-015021-pol2qm74	7047	7	(	(	-LRB-
cord-015021-pol2qm74	7047	8	p	p	NN
cord-015021-pol2qm74	7047	9	<	<	XX
cord-015021-pol2qm74	7047	10	O,01	O,01	NNP
cord-015021-pol2qm74	7047	11	)	)	-RRB-
cord-015021-pol2qm74	7047	12	of	of	IN
cord-015021-pol2qm74	7047	13	the	the	DT
cord-015021-pol2qm74	7047	14	septic	septic	JJ
cord-015021-pol2qm74	7047	15	patients	patient	NNS
cord-015021-pol2qm74	7047	16	showed	show	VBD
cord-015021-pol2qm74	7047	17	a	a	DT
cord-015021-pol2qm74	7047	18	significantly	significantly	RB
cord-015021-pol2qm74	7047	19	enhanced	enhance	VBN
cord-015021-pol2qm74	7047	20	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7047	21	compared	compare	VBN
cord-015021-pol2qm74	7047	22	toLhe	tolhe	NN
cord-015021-pol2qm74	7047	23	phagocytes	phagocyte	NNS
cord-015021-pol2qm74	7047	24	of	of	IN
cord-015021-pol2qm74	7047	25	the	the	DT
cord-015021-pol2qm74	7047	26	healthy	healthy	JJ
cord-015021-pol2qm74	7047	27	group	group	NN
cord-015021-pol2qm74	7047	28	.	.	.
cord-015021-pol2qm74	7048	1	The	the	DT
cord-015021-pol2qm74	7048	2	incubation	incubation	NN
cord-015021-pol2qm74	7048	3	with	with	IN
cord-015021-pol2qm74	7048	4	the	the	DT
cord-015021-pol2qm74	7048	5	enteral	enteral	JJ
cord-015021-pol2qm74	7048	6	diet	diet	NN
cord-015021-pol2qm74	7048	7	in	in	IN
cord-015021-pol2qm74	7048	8	vitro	vitro	FW
cord-015021-pol2qm74	7048	9	was	be	VBD
cord-015021-pol2qm74	7048	10	followed	follow	VBN
cord-015021-pol2qm74	7048	11	by	by	IN
cord-015021-pol2qm74	7048	12	a	a	DT
cord-015021-pol2qm74	7048	13	higher	high	JJR
cord-015021-pol2qm74	7048	14	dose	dose	NN
cord-015021-pol2qm74	7048	15	-	-	HYPH
cord-015021-pol2qm74	7048	16	related	relate	VBN
cord-015021-pol2qm74	7048	17	rate	rate	NN
cord-015021-pol2qm74	7048	18	of	of	IN
cord-015021-pol2qm74	7048	19	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7048	20	,	,	,
cord-015021-pol2qm74	7048	21	especially	especially	RB
cord-015021-pol2qm74	7048	22	in	in	IN
cord-015021-pol2qm74	7048	23	the	the	DT
cord-015021-pol2qm74	7048	24	healthy	healthy	JJ
cord-015021-pol2qm74	7048	25	group	group	NN
cord-015021-pol2qm74	7048	26	,	,	,
cord-015021-pol2qm74	7048	27	that	that	WDT
cord-015021-pol2qm74	7048	28	was	be	VBD
cord-015021-pol2qm74	7048	29	not	not	RB
cord-015021-pol2qm74	7048	30	statistically	statistically	RB
cord-015021-pol2qm74	7048	31	significant	significant	JJ
cord-015021-pol2qm74	7048	32	.	.	.
cord-015021-pol2qm74	7049	1	After	after	IN
cord-015021-pol2qm74	7049	2	addition	addition	NN
cord-015021-pol2qm74	7049	3	of	of	IN
cord-015021-pol2qm74	7049	4	L	L	NNP
cord-015021-pol2qm74	7049	5	-	-	HYPH
cord-015021-pol2qm74	7049	6	Argintne	Argintne	NNP
cord-015021-pol2qm74	7049	7	we	-PRON-	PRP
cord-015021-pol2qm74	7049	8	atso	atso	RB
cord-015021-pol2qm74	7049	9	observed	observe	VBD
cord-015021-pol2qm74	7049	10	an	an	DT
cord-015021-pol2qm74	7049	11	iqcrease	iqcrease	NN
cord-015021-pol2qm74	7049	12	in	in	IN
cord-015021-pol2qm74	7049	13	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7049	14	,	,	,
cord-015021-pol2qm74	7049	15	that	that	WDT
cord-015021-pol2qm74	7049	16	was	be	VBD
cord-015021-pol2qm74	7049	17	lower	low	JJR
cord-015021-pol2qm74	7049	18	than	than	IN
cord-015021-pol2qm74	7049	19	in	in	IN
cord-015021-pol2qm74	7049	20	the	the	DT
cord-015021-pol2qm74	7049	21	group	group	NN
cord-015021-pol2qm74	7049	22	with	with	IN
cord-015021-pol2qm74	7049	23	the	the	DT
cord-015021-pol2qm74	7049	24	complete	complete	JJ
cord-015021-pol2qm74	7049	25	diet	diet	NN
cord-015021-pol2qm74	7049	26	.	.	.
cord-015021-pol2qm74	7050	1	Using	use	VBG
cord-015021-pol2qm74	7050	2	a	a	DT
cord-015021-pol2qm74	7050	3	modern	modern	JJ
cord-015021-pol2qm74	7050	4	immunefluorescence	immunefluorescence	NN
cord-015021-pol2qm74	7050	5	-	-	HYPH
cord-015021-pol2qm74	7050	6	cytometric	cytometric	NN
cord-015021-pol2qm74	7050	7	essay	essay	NN
cord-015021-pol2qm74	7050	8	we	-PRON-	PRP
cord-015021-pol2qm74	7050	9	founfl	founfl	VBP
cord-015021-pol2qm74	7050	10	an	an	DT
cord-015021-pol2qm74	7050	11	improved	improve	VBN
cord-015021-pol2qm74	7050	12	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7050	13	function	function	NN
cord-015021-pol2qm74	7050	14	in	in	IN
cord-015021-pol2qm74	7050	15	septic	septic	JJ
cord-015021-pol2qm74	7050	16	shosk	shosk	NN
cord-015021-pol2qm74	7050	17	.	.	.
cord-015021-pol2qm74	7051	1	There	there	EX
cord-015021-pol2qm74	7051	2	are	be	VBP
cord-015021-pol2qm74	7051	3	signs	sign	NNS
cord-015021-pol2qm74	7051	4	for	for	IN
cord-015021-pol2qm74	7051	5	an	an	DT
cord-015021-pol2qm74	7051	6	influence	influence	NN
cord-015021-pol2qm74	7051	7	of	of	IN
cord-015021-pol2qm74	7051	8	nutrient	nutrient	NN
cord-015021-pol2qm74	7051	9	substrates	substrate	NNS
cord-015021-pol2qm74	7051	10	on	on	IN
cord-015021-pol2qm74	7051	11	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7051	12	which	which	WDT
cord-015021-pol2qm74	7051	13	seems	seem	VBZ
cord-015021-pol2qm74	7051	14	to	to	TO
cord-015021-pol2qm74	7051	15	be	be	VB
cord-015021-pol2qm74	7051	16	complex	complex	JJ
cord-015021-pol2qm74	7051	17	and	and	CC
cord-015021-pol2qm74	7051	18	should	should	MD
cord-015021-pol2qm74	7051	19	be	be	VB
cord-015021-pol2qm74	7051	20	further	further	RB
cord-015021-pol2qm74	7051	21	investigated	investigate	VBN
cord-015021-pol2qm74	7051	22	.	.	.
cord-015021-pol2qm74	7052	1	ARG	ARG	NNP
cord-015021-pol2qm74	7052	2	and	and	CC
cord-015021-pol2qm74	7052	3	GLN	GLN	NNP
cord-015021-pol2qm74	7052	4	were	be	VBD
cord-015021-pol2qm74	7052	5	lower	low	JJR
cord-015021-pol2qm74	7052	6	in	in	IN
cord-015021-pol2qm74	7052	7	the	the	DT
cord-015021-pol2qm74	7052	8	49%-BCAA	49%-bcaa	CD
cord-015021-pol2qm74	7052	9	vs	vs	IN
cord-015021-pol2qm74	7052	10	16%-BCAA	16%-bcaa	CD
cord-015021-pol2qm74	7052	11	group	group	NN
cord-015021-pol2qm74	7052	12	;	;	:
cord-015021-pol2qm74	7052	13	ARG	ARG	NNP
cord-015021-pol2qm74	7052	14	was	be	VBD
cord-015021-pol2qm74	7052	15	related	relate	VBN
cord-015021-pol2qm74	7052	16	directly	directly	RB
cord-015021-pol2qm74	7052	17	to	to	IN
cord-015021-pol2qm74	7052	18	ARG	arg	NN
cord-015021-pol2qm74	7052	19	dose	dose	NN
cord-015021-pol2qm74	7052	20	and	and	CC
cord-015021-pol2qm74	7052	21	inversely	inversely	RB
cord-015021-pol2qm74	7052	22	to	to	IN
cord-015021-pol2qm74	7052	23	BCAA	BCAA	NNP
cord-015021-pol2qm74	7052	24	dose	dose	NN
cord-015021-pol2qm74	7052	25	(	(	-LRB-
cord-015021-pol2qm74	7052	26	p	p	NN
cord-015021-pol2qm74	7052	27	<	<	XX
cord-015021-pol2qm74	7052	28	O.O01	o.o01	RB
cord-015021-pol2qm74	7052	29	for	for	IN
cord-015021-pol2qm74	7052	30	all	all	DT
cord-015021-pol2qm74	7052	31	)	)	-RRB-
cord-015021-pol2qm74	7052	32	.	.	.
cord-015021-pol2qm74	7053	1	Clearances	clearance	NNS
cord-015021-pol2qm74	7053	2	of	of	IN
cord-015021-pol2qm74	7053	3	BCAA	BCAA	NNP
cord-015021-pol2qm74	7053	4	increased	increase	VBD
cord-015021-pol2qm74	7053	5	with	with	IN
cord-015021-pol2qm74	7053	6	increasing	increase	VBG
cord-015021-pol2qm74	7053	7	BCAA	BCAA	NNP
cord-015021-pol2qm74	7053	8	dose	dose	NN
cord-015021-pol2qm74	7053	9	(	(	-LRB-
cord-015021-pol2qm74	7053	10	p	p	NN
cord-015021-pol2qm74	7053	11	<	<	XX
cord-015021-pol2qm74	7053	12	O.O01	o.o01	NN
cord-015021-pol2qm74	7053	13	)	)	-RRB-
cord-015021-pol2qm74	7053	14	;	;	:
cord-015021-pol2qm74	7053	15	ARG	ARG	NNP
cord-015021-pol2qm74	7053	16	and	and	CC
cord-015021-pol2qm74	7053	17	GLN	GLN	NNP
cord-015021-pol2qm74	7053	18	clearances	clearance	NNS
cord-015021-pol2qm74	7053	19	were	be	VBD
cord-015021-pol2qm74	7053	20	directly	directly	RB
cord-015021-pol2qm74	7053	21	related	relate	VBN
cord-015021-pol2qm74	7053	22	to	to	IN
cord-015021-pol2qm74	7053	23	the	the	DT
cord-015021-pol2qm74	7053	24	BCAA	BCAA	NNP
cord-015021-pol2qm74	7053	25	clearances	clearance	NNS
cord-015021-pol2qm74	7053	26	(	(	-LRB-
cord-015021-pol2qm74	7053	27	rZ	rZ	NNP
cord-015021-pol2qm74	7053	28	=	=	SYM
cord-015021-pol2qm74	7053	29	O.65	o.65	NN
cord-015021-pol2qm74	7053	30	,	,	,
cord-015021-pol2qm74	7053	31	p	p	NN
cord-015021-pol2qm74	7053	32	<	<	XX
cord-015021-pol2qm74	7053	33	O.O0i	O.O0i	NNP
cord-015021-pol2qm74	7053	34	)	)	-RRB-
cord-015021-pol2qm74	7053	35	.	.	.
cord-015021-pol2qm74	7054	1	Relationships	relationship	NNS
cord-015021-pol2qm74	7054	2	between	between	IN
cord-015021-pol2qm74	7054	3	ARG	arg	NN
cord-015021-pol2qm74	7054	4	,	,	,
cord-015021-pol2qm74	7054	5	GLN	GLN	NNP
cord-015021-pol2qm74	7054	6	and	and	CC
cord-015021-pol2qm74	7054	7	other	other	JJ
cord-015021-pol2qm74	7054	8	AA	AA	NNP
cord-015021-pol2qm74	7054	9	seem	seem	VBP
cord-015021-pol2qm74	7054	10	to	to	TO
cord-015021-pol2qm74	7054	11	be	be	VB
cord-015021-pol2qm74	7054	12	ruled	rule	VBN
cord-015021-pol2qm74	7054	13	by	by	IN
cord-015021-pol2qm74	7054	14	patterns	pattern	NNS
cord-015021-pol2qm74	7054	15	involving	involve	VBG
cord-015021-pol2qm74	7054	16	specific	specific	JJ
cord-015021-pol2qm74	7054	17	intracellular	intracellular	JJ
cord-015021-pol2qm74	7054	18	AA	AA	NNP
cord-015021-pol2qm74	7054	19	transport	transport	NN
cord-015021-pol2qm74	7054	20	systems	system	NNS
cord-015021-pol2qm74	7054	21	.	.	.
cord-015021-pol2qm74	7055	1	Regulation	regulation	NN
cord-015021-pol2qm74	7055	2	of	of	IN
cord-015021-pol2qm74	7055	3	ARG	arg	NN
cord-015021-pol2qm74	7055	4	and	and	CC
cord-015021-pol2qm74	7055	5	GLN	GLN	NNP
cord-015021-pol2qm74	7055	6	clearances	clearance	NNS
cord-015021-pol2qm74	7055	7	through	through	IN
cord-015021-pol2qm74	7055	8	BCAA	BCAA	NNP
cord-015021-pol2qm74	7055	9	administration	administration	NN
cord-015021-pol2qm74	7055	10	may	may	MD
cord-015021-pol2qm74	7055	11	be	be	VB
cord-015021-pol2qm74	7055	12	related	relate	VBN
cord-015021-pol2qm74	7055	13	to	to	IN
cord-015021-pol2qm74	7055	14	an	an	DT
cord-015021-pol2qm74	7055	15	increased	increase	VBN
cord-015021-pol2qm74	7055	16	flux	flux	NN
cord-015021-pol2qm74	7055	17	of	of	IN
cord-015021-pol2qm74	7055	18	AA	AA	NNP
cord-015021-pol2qm74	7055	19	into	into	IN
cord-015021-pol2qm74	7055	20	synthetic	synthetic	JJ
cord-015021-pol2qm74	7055	21	processes	process	NNS
cord-015021-pol2qm74	7055	22	.	.	.
cord-015021-pol2qm74	7056	1	Intestinal	intestinal	JJ
cord-015021-pol2qm74	7056	2	segments	segment	NNS
cord-015021-pol2qm74	7056	3	from	from	IN
cord-015021-pol2qm74	7056	4	rats	rat	NNS
cord-015021-pol2qm74	7056	5	immunized	immunize	VBN
cord-015021-pol2qm74	7056	6	by	by	IN
cord-015021-pol2qm74	7056	7	infection	infection	NN
cord-015021-pol2qm74	7056	8	with	with	IN
cord-015021-pol2qm74	7056	9	the	the	DT
cord-015021-pol2qm74	7056	10	nematode	nematode	NN
cord-015021-pol2qm74	7056	11	Trichinella	Trichinella	NNP
cord-015021-pol2qm74	7056	12	spiruUs	spiruu	NNS
cord-015021-pol2qm74	7056	13	undergo	undergo	VBP
cord-015021-pol2qm74	7056	14	intestinal	intestinal	JJ
cord-015021-pol2qm74	7056	15	anaphylaxis	anaphylaxis	NN
cord-015021-pol2qm74	7056	16	or	or	CC
cord-015021-pol2qm74	7056	17	type	type	NN
cord-015021-pol2qm74	7056	18	I	-PRON-	PRP
cord-015021-pol2qm74	7056	19	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	7056	20	when	when	WRB
cord-015021-pol2qm74	7056	21	challenged	challenge	VBN
cord-015021-pol2qm74	7056	22	in	in	IN
cord-015021-pol2qm74	7056	23	vitro	vitro	FW
cord-015021-pol2qm74	7056	24	with	with	IN
cord-015021-pol2qm74	7056	25	parasite	parasite	NN
cord-015021-pol2qm74	7056	26	antigen	antigen	NN
cord-015021-pol2qm74	7056	27	.	.	.
cord-015021-pol2qm74	7057	1	Immunized	immunize	VBN
cord-015021-pol2qm74	7057	2	rats	rat	NNS
cord-015021-pol2qm74	7057	3	exposed	expose	VBN
cord-015021-pol2qm74	7057	4	to	to	IN
cord-015021-pol2qm74	7057	5	T	t	NN
cord-015021-pol2qm74	7057	6	-	-	HYPH
cord-015021-pol2qm74	7057	7	radiation	radiation	NN
cord-015021-pol2qm74	7057	8	(	(	-LRB-
cord-015021-pol2qm74	7057	9	7Gy	7Gy	NNP
cord-015021-pol2qm74	7057	10	)	)	-RRB-
cord-015021-pol2qm74	7057	11	and	and	CC
cord-015021-pol2qm74	7057	12	sustained	sustain	VBD
cord-015021-pol2qm74	7057	13	on	on	IN
cord-015021-pol2qm74	7057	14	rat	rat	NN
cord-015021-pol2qm74	7057	15	chow	chow	NN
cord-015021-pol2qm74	7057	16	,	,	,
cord-015021-pol2qm74	7057	17	fail	fail	VBP
cord-015021-pol2qm74	7057	18	to	to	TO
cord-015021-pol2qm74	7057	19	fully	fully	RB
cord-015021-pol2qm74	7057	20	express	express	VB
cord-015021-pol2qm74	7057	21	type	type	NN
cord-015021-pol2qm74	7057	22	I	-PRON-	PRP
cord-015021-pol2qm74	7057	23	hypersensitivity	hypersensitivity	VBP
cord-015021-pol2qm74	7057	24	up	up	RP
cord-015021-pol2qm74	7057	25	to	to	TO
cord-015021-pol2qm74	7057	26	14	14	CD
cord-015021-pol2qm74	7057	27	Days	day	NNS
cord-015021-pol2qm74	7058	1	Post	Post	NNP
cord-015021-pol2qm74	7058	2	Irradiation	Irradiation	NNP
cord-015021-pol2qm74	7058	3	(	(	-LRB-
cord-015021-pol2qm74	7058	4	DPI	DPI	NNP
cord-015021-pol2qm74	7058	5	)	)	-RRB-
cord-015021-pol2qm74	7058	6	.	.	.
cord-015021-pol2qm74	7059	1	We	-PRON-	PRP
cord-015021-pol2qm74	7059	2	hypothesized	hypothesize	VBD
cord-015021-pol2qm74	7059	3	that	that	IN
cord-015021-pol2qm74	7059	4	enteral	enteral	JJ
cord-015021-pol2qm74	7059	5	nutritional	nutritional	JJ
cord-015021-pol2qm74	7059	6	support	support	NN
cord-015021-pol2qm74	7059	7	immediately	immediately	RB
cord-015021-pol2qm74	7059	8	following	follow	VBG
cord-015021-pol2qm74	7059	9	irradiation	irradiation	NN
cord-015021-pol2qm74	7059	10	may	may	MD
cord-015021-pol2qm74	7059	11	be	be	VB
cord-015021-pol2qm74	7059	12	effective	effective	JJ
cord-015021-pol2qm74	7059	13	in	in	IN
cord-015021-pol2qm74	7059	14	preserving	preserve	VBG
cord-015021-pol2qm74	7059	15	mucosal	mucosal	JJ
cord-015021-pol2qm74	7059	16	immune	immune	JJ
cord-015021-pol2qm74	7059	17	responsiveness	responsiveness	NN
cord-015021-pol2qm74	7059	18	or	or	CC
cord-015021-pol2qm74	7059	19	in	in	IN
cord-015021-pol2qm74	7059	20	reducing	reduce	VBG
cord-015021-pol2qm74	7059	21	the	the	DT
cord-015021-pol2qm74	7059	22	recovery	recovery	NN
cord-015021-pol2qm74	7059	23	time	time	NN
cord-015021-pol2qm74	7059	24	after	after	IN
cord-015021-pol2qm74	7059	25	radiation	radiation	NN
cord-015021-pol2qm74	7059	26	-	-	HYPH
cord-015021-pol2qm74	7059	27	induced	induce	VBN
cord-015021-pol2qm74	7059	28	injury	injury	NN
cord-015021-pol2qm74	7059	29	.	.	.
cord-015021-pol2qm74	7060	1	Rats	rat	NNS
cord-015021-pol2qm74	7060	2	were	be	VBD
cord-015021-pol2qm74	7060	3	infected	infect	VBN
cord-015021-pol2qm74	7060	4	with	with	IN
cord-015021-pol2qm74	7060	5	3x103	3x103	CD
cord-015021-pol2qm74	7060	6	T.spiralis	T.spiralis	NNP
cord-015021-pol2qm74	7060	7	larvae	larva	NNS
cord-015021-pol2qm74	7060	8	.	.	.
cord-015021-pol2qm74	7061	1	Thirty	thirty	CD
cord-015021-pol2qm74	7061	2	to	to	TO
cord-015021-pol2qm74	7061	3	fifty	fifty	CD
cord-015021-pol2qm74	7061	4	days	day	NNS
cord-015021-pol2qm74	7061	5	later	later	RBR
cord-015021-pol2qm74	7061	6	rats	rat	NNS
cord-015021-pol2qm74	7061	7	received	receive	VBD
cord-015021-pol2qm74	7061	8	7Gy	7Gy	NNP
cord-015021-pol2qm74	7061	9	T	t	NN
cord-015021-pol2qm74	7061	10	-	-	HYPH
cord-015021-pol2qm74	7061	11	radiation	radiation	NN
cord-015021-pol2qm74	7061	12	from	from	IN
cord-015021-pol2qm74	7061	13	a	a	DT
cord-015021-pol2qm74	7061	14	Co	Co	NNP
cord-015021-pol2qm74	7061	15	source	source	NN
cord-015021-pol2qm74	7061	16	as	as	IN
cord-015021-pol2qm74	7061	17	total	total	JJ
cord-015021-pol2qm74	7061	18	abdominal	abdominal	JJ
cord-015021-pol2qm74	7061	19	irradiation	irradiation	NN
cord-015021-pol2qm74	7061	20	(	(	-LRB-
cord-015021-pol2qm74	7061	21	TAI	TAI	NNP
cord-015021-pol2qm74	7061	22	)	)	-RRB-
cord-015021-pol2qm74	7061	23	.	.	.
cord-015021-pol2qm74	7062	1	Immediately	immediately	RB
cord-015021-pol2qm74	7062	2	following	follow	VBG
cord-015021-pol2qm74	7062	3	TAI	TAI	NNP
cord-015021-pol2qm74	7062	4	,	,	,
cord-015021-pol2qm74	7062	5	rats	rat	NNS
cord-015021-pol2qm74	7062	6	were	be	VBD
cord-015021-pol2qm74	7062	7	fed	feed	VBN
cord-015021-pol2qm74	7062	8	an	an	DT
cord-015021-pol2qm74	7062	9	elemental	elemental	JJ
cord-015021-pol2qm74	7062	10	amino	amino	NN
cord-015021-pol2qm74	7062	11	acid	acid	NN
cord-015021-pol2qm74	7062	12	diet	diet	NN
cord-015021-pol2qm74	7062	13	(	(	-LRB-
cord-015021-pol2qm74	7062	14	EAAD	EAAD	NNP
cord-015021-pol2qm74	7062	15	)	)	-RRB-
cord-015021-pol2qm74	7062	16	and	and	CC
cord-015021-pol2qm74	7062	17	at	at	IN
cord-015021-pol2qm74	7062	18	various	various	JJ
cord-015021-pol2qm74	7062	19	DPI	DPI	NNP
cord-015021-pol2qm74	7062	20	sacrificed	sacrifice	VBD
cord-015021-pol2qm74	7062	21	and	and	CC
cord-015021-pol2qm74	7062	22	tested	test	VBN
cord-015021-pol2qm74	7062	23	in	in	IN
cord-015021-pol2qm74	7062	24	Ussing	Ussing	NNP
cord-015021-pol2qm74	7062	25	chambers	chamber	NNS
cord-015021-pol2qm74	7062	26	for	for	IN
cord-015021-pol2qm74	7062	27	local	local	JJ
cord-015021-pol2qm74	7062	28	anaphylaxis	anaphylaxis	NN
cord-015021-pol2qm74	7062	29	,	,	,
cord-015021-pol2qm74	7062	30	expressed	express	VBN
cord-015021-pol2qm74	7062	31	as	as	IN
cord-015021-pol2qm74	7062	32	antigen	antigen	NN
cord-015021-pol2qm74	7062	33	-	-	HYPH
cord-015021-pol2qm74	7062	34	induced	induce	VBN
cord-015021-pol2qm74	7062	35	CI	CI	NNP
cord-015021-pol2qm74	7062	36	secretion	secretion	NN
cord-015021-pol2qm74	7062	37	.	.	.
cord-015021-pol2qm74	7063	1	The	the	DT
cord-015021-pol2qm74	7063	2	normal	normal	JJ
cord-015021-pol2qm74	7063	3	CI	CI	NNP
cord-015021-pol2qm74	7063	4	secretory	secretory	JJ
cord-015021-pol2qm74	7063	5	response	response	NN
cord-015021-pol2qm74	7063	6	to	to	IN
cord-015021-pol2qm74	7063	7	antigenic	antigenic	JJ
cord-015021-pol2qm74	7063	8	challenge	challenge	NN
cord-015021-pol2qm74	7063	9	which	which	WDT
cord-015021-pol2qm74	7063	10	is	be	VBZ
cord-015021-pol2qm74	7063	11	suppressed	suppress	VBN
cord-015021-pol2qm74	7063	12	after	after	IN
cord-015021-pol2qm74	7063	13	irradiation	irradiation	NN
cord-015021-pol2qm74	7063	14	,	,	,
cord-015021-pol2qm74	7063	15	was	be	VBD
cord-015021-pol2qm74	7063	16	restored	restore	VBN
cord-015021-pol2qm74	7063	17	by	by	IN
cord-015021-pol2qm74	7063	18	3	3	CD
cord-015021-pol2qm74	7063	19	DPI	DPI	NNP
cord-015021-pol2qm74	7063	20	when	when	WRB
cord-015021-pol2qm74	7063	21	rats	rat	NNS
cord-015021-pol2qm74	7063	22	were	be	VBD
cord-015021-pol2qm74	7063	23	placed	place	VBN
cord-015021-pol2qm74	7063	24	on	on	IN
cord-015021-pol2qm74	7063	25	the	the	DT
cord-015021-pol2qm74	7063	26	EAAD	EAAD	NNP
cord-015021-pol2qm74	7063	27	.	.	.
cord-015021-pol2qm74	7064	1	Antigen	antigen	NN
cord-015021-pol2qm74	7064	2	-	-	HYPH
cord-015021-pol2qm74	7064	3	induced	induce	VBN
cord-015021-pol2qm74	7064	4	C	c	NN
cord-015021-pol2qm74	7064	5	[	[	-LRB-
cord-015021-pol2qm74	7064	6	secretion	secretion	NN
cord-015021-pol2qm74	7064	7	is	be	VBZ
cord-015021-pol2qm74	7064	8	dependent	dependent	JJ
cord-015021-pol2qm74	7064	9	on	on	IN
cord-015021-pol2qm74	7064	10	the	the	DT
cord-015021-pol2qm74	7064	11	interaction	interaction	NN
cord-015021-pol2qm74	7064	12	o~	o~	CD
cord-015021-pol2qm74	7064	13	antigen	antigen	NN
cord-015021-pol2qm74	7064	14	with	with	IN
cord-015021-pol2qm74	7064	15	specific	specific	JJ
cord-015021-pol2qm74	7064	16	IgE	IgE	NNP
cord-015021-pol2qm74	7064	17	antibodies	antibody	NNS
cord-015021-pol2qm74	7064	18	on	on	IN
cord-015021-pol2qm74	7064	19	the	the	DT
cord-015021-pol2qm74	7064	20	surface	surface	NN
cord-015021-pol2qm74	7064	21	o5	o5	NNP
cord-015021-pol2qm74	7064	22	mucosal	mucosal	NN
cord-015021-pol2qm74	7064	23	mast	mast	NN
cord-015021-pol2qm74	7064	24	cells	cell	NNS
cord-015021-pol2qm74	7064	25	and	and	CC
cord-015021-pol2qm74	7064	26	their	-PRON-	PRP$
cord-015021-pol2qm74	7064	27	subsequent	subsequent	JJ
cord-015021-pol2qm74	7064	28	degranulation	degranulation	NN
cord-015021-pol2qm74	7064	29	.	.	.
cord-015021-pol2qm74	7065	1	Mast	mast	JJ
cord-015021-pol2qm74	7065	2	cell	cell	NN
cord-015021-pol2qm74	7065	3	-	-	HYPH
cord-015021-pol2qm74	7065	4	derived	derive	VBN
cord-015021-pol2qm74	7065	5	5-HT	5-ht	CD
cord-015021-pol2qm74	7065	6	,	,	,
cord-015021-pol2qm74	7065	7	histamine	histamine	NN
cord-015021-pol2qm74	7065	8	and	and	CC
cord-015021-pol2qm74	7065	9	PG	PG	NNP
cord-015021-pol2qm74	7065	10	,	,	,
cord-015021-pol2qm74	7065	11	together	together	RB
cord-015021-pol2qm74	7065	12	effect	effect	NN
cord-015021-pol2qm74	7065	13	CI	CI	NNP
cord-015021-pol2qm74	7065	14	secretion	secretion	NN
cord-015021-pol2qm74	7065	15	.	.	.
cord-015021-pol2qm74	7066	1	In	in	IN
cord-015021-pol2qm74	7066	2	irradiated	irradiate	VBN
cord-015021-pol2qm74	7066	3	rats	rat	NNS
cord-015021-pol2qm74	7066	4	on	on	IN
cord-015021-pol2qm74	7066	5	rat	rat	NN
cord-015021-pol2qm74	7066	6	chow	chow	NNP
cord-015021-pol2qm74	7066	7	,	,	,
cord-015021-pol2qm74	7066	8	the	the	DT
cord-015021-pol2qm74	7066	9	failure	failure	NN
cord-015021-pol2qm74	7066	10	to	to	TO
cord-015021-pol2qm74	7066	11	respond	respond	VB
cord-015021-pol2qm74	7066	12	to	to	IN
cord-015021-pol2qm74	7066	13	antigenic	antigenic	JJ
cord-015021-pol2qm74	7066	14	challenge	challenge	NN
cord-015021-pol2qm74	7066	15	appears	appear	VBZ
cord-015021-pol2qm74	7066	16	to	to	TO
cord-015021-pol2qm74	7066	17	be	be	VB
cord-015021-pol2qm74	7066	18	associated	associate	VBN
cord-015021-pol2qm74	7066	19	with	with	IN
cord-015021-pol2qm74	7066	20	the	the	DT
cord-015021-pol2qm74	7066	21	destruction	destruction	NN
cord-015021-pol2qm74	7066	22	of	of	IN
cord-015021-pol2qm74	7066	23	mast	mast	NN
cord-015021-pol2qm74	7066	24	cells	cell	NNS
cord-015021-pol2qm74	7066	25	.	.	.
cord-015021-pol2qm74	7067	1	They	-PRON-	PRP
cord-015021-pol2qm74	7067	2	are	be	VBP
cord-015021-pol2qm74	7067	3	undetectable	undetectable	JJ
cord-015021-pol2qm74	7067	4	with	with	IN
cord-015021-pol2qm74	7067	5	standard	standard	JJ
cord-015021-pol2qm74	7067	6	staining	stain	VBG
cord-015021-pol2qm74	7067	7	procedures	procedure	NNS
cord-015021-pol2qm74	7067	8	and	and	CC
cord-015021-pol2qm74	7067	9	mucosal	mucosal	JJ
cord-015021-pol2qm74	7067	10	histamine	histamine	NN
cord-015021-pol2qm74	7067	11	levels	level	NNS
cord-015021-pol2qm74	7067	12	are	be	VBP
cord-015021-pol2qm74	7067	13	drastically	drastically	RB
cord-015021-pol2qm74	7067	14	reduced	reduce	VBN
cord-015021-pol2qm74	7067	15	.	.	.
cord-015021-pol2qm74	7068	1	Also	also	RB
cord-015021-pol2qm74	7068	2	,	,	,
cord-015021-pol2qm74	7068	3	el	el	NNP
cord-015021-pol2qm74	7068	4	secretion	secretion	NN
cord-015021-pol2qm74	7068	5	can	can	MD
cord-015021-pol2qm74	7068	6	be	be	VB
cord-015021-pol2qm74	7068	7	induced	induce	VBN
cord-015021-pol2qm74	7068	8	by	by	IN
cord-015021-pol2qm74	7068	9	direct	direct	JJ
cord-015021-pol2qm74	7068	10	stimulation	stimulation	NN
cord-015021-pol2qm74	7068	11	of	of	IN
cord-015021-pol2qm74	7068	12	epithelium	epithelium	NN
cord-015021-pol2qm74	7068	13	with	with	IN
cord-015021-pol2qm74	7068	14	cr	cr	NNP
cord-015021-pol2qm74	7068	15	secrctagogues	secrctagogues	NNP
cord-015021-pol2qm74	7068	16	and	and	CC
cord-015021-pol2qm74	7068	17	circulating	circulate	VBG
cord-015021-pol2qm74	7068	18	IgE	IgE	NNP
cord-015021-pol2qm74	7068	19	levels	level	NNS
cord-015021-pol2qm74	7068	20	are	be	VBP
cord-015021-pol2qm74	7068	21	normal	normal	JJ
cord-015021-pol2qm74	7068	22	.	.	.
cord-015021-pol2qm74	7069	1	Despite	despite	IN
cord-015021-pol2qm74	7069	2	a	a	DT
cord-015021-pol2qm74	7069	3	more	more	RBR
cord-015021-pol2qm74	7069	4	rapid	rapid	JJ
cord-015021-pol2qm74	7069	5	recovery	recovery	NN
cord-015021-pol2qm74	7069	6	of	of	IN
cord-015021-pol2qm74	7069	7	immune	immune	JJ
cord-015021-pol2qm74	7069	8	responsiveness	responsiveness	NN
cord-015021-pol2qm74	7069	9	in	in	IN
cord-015021-pol2qm74	7069	10	irradiated	irradiate	VBN
cord-015021-pol2qm74	7069	11	rats	rat	NNS
cord-015021-pol2qm74	7069	12	receiving	receive	VBG
cord-015021-pol2qm74	7069	13	EAAD	EAAD	NNP
cord-015021-pol2qm74	7069	14	,	,	,
cord-015021-pol2qm74	7069	15	mast	mast	NN
cord-015021-pol2qm74	7069	16	cells	cell	NNS
cord-015021-pol2qm74	7069	17	were	be	VBD
cord-015021-pol2qm74	7069	18	not	not	RB
cord-015021-pol2qm74	7069	19	restored	restore	VBN
cord-015021-pol2qm74	7069	20	.	.	.
cord-015021-pol2qm74	7070	1	We	-PRON-	PRP
cord-015021-pol2qm74	7070	2	conclude	conclude	VBP
cord-015021-pol2qm74	7070	3	that	that	IN
cord-015021-pol2qm74	7070	4	the	the	DT
cord-015021-pol2qm74	7070	5	EAAD	EAAD	NNP
cord-015021-pol2qm74	7070	6	contributes	contribute	VBZ
cord-015021-pol2qm74	7070	7	to	to	IN
cord-015021-pol2qm74	7070	8	an	an	DT
cord-015021-pol2qm74	7070	9	adaptation	adaptation	NN
cord-015021-pol2qm74	7070	10	that	that	WDT
cord-015021-pol2qm74	7070	11	supports	support	VBZ
cord-015021-pol2qm74	7070	12	the	the	DT
cord-015021-pol2qm74	7070	13	expression	expression	NN
cord-015021-pol2qm74	7070	14	of	of	IN
cord-015021-pol2qm74	7070	15	local	local	JJ
cord-015021-pol2qm74	7070	16	anaphylaxis	anaphylaxis	NN
cord-015021-pol2qm74	7070	17	in	in	IN
cord-015021-pol2qm74	7070	18	the	the	DT
cord-015021-pol2qm74	7070	19	absence	absence	NN
cord-015021-pol2qm74	7070	20	of	of	IN
cord-015021-pol2qm74	7070	21	mast	mast	NN
cord-015021-pol2qm74	7070	22	cells	cell	NNS
cord-015021-pol2qm74	7070	23	.	.	.
cord-015021-pol2qm74	7071	1	Total	total	JJ
cord-015021-pol2qm74	7071	2	parenteral	parenteral	JJ
cord-015021-pol2qm74	7071	3	nutrition	nutrition	NN
cord-015021-pol2qm74	7071	4	(	(	-LRB-
cord-015021-pol2qm74	7071	5	PN	PN	NNP
cord-015021-pol2qm74	7071	6	)	)	-RRB-
cord-015021-pol2qm74	7071	7	and	and	CC
cord-015021-pol2qm74	7072	1	bowel	bowel	NN
cord-015021-pol2qm74	7072	2	rest	rest	NN
cord-015021-pol2qm74	7072	3	may	may	MD
cord-015021-pol2qm74	7072	4	influence	influence	VB
cord-015021-pol2qm74	7072	5	the	the	DT
cord-015021-pol2qm74	7072	6	host	host	NN
cord-015021-pol2qm74	7072	7	response	response	NN
cord-015021-pol2qm74	7072	8	to	to	IN
cord-015021-pol2qm74	7072	9	infection	infection	NN
cord-015021-pol2qm74	7072	10	.	.	.
cord-015021-pol2qm74	7073	1	This	this	DT
cord-015021-pol2qm74	7073	2	study	study	NN
cord-015021-pol2qm74	7073	3	examined	examine	VBD
cord-015021-pol2qm74	7073	4	the	the	DT
cord-015021-pol2qm74	7073	5	different	different	JJ
cord-015021-pol2qm74	7073	6	host	host	NN
cord-015021-pol2qm74	7073	7	response	response	NN
cord-015021-pol2qm74	7073	8	to	to	IN
cord-015021-pol2qm74	7073	9	infection	infection	NN
cord-015021-pol2qm74	7073	10	in	in	IN
cord-015021-pol2qm74	7073	11	parenterally	parenterally	NN
cord-015021-pol2qm74	7073	12	and	and	CC
cord-015021-pol2qm74	7073	13	enterally	enterally	RB
cord-015021-pol2qm74	7073	14	fed	fed	JJ
cord-015021-pol2qm74	7073	15	animals	animal	NNS
cord-015021-pol2qm74	7073	16	.	.	.
cord-015021-pol2qm74	7074	1	Forty	forty	CD
cord-015021-pol2qm74	7074	2	-	-	HYPH
cord-015021-pol2qm74	7074	3	three	three	CD
cord-015021-pol2qm74	7074	4	rats	rat	NNS
cord-015021-pol2qm74	7074	5	were	be	VBD
cord-015021-pol2qm74	7074	6	divided	divide	VBN
cord-015021-pol2qm74	7074	7	into	into	IN
cord-015021-pol2qm74	7074	8	PN	PN	NNP
cord-015021-pol2qm74	7074	9	group	group	NN
cord-015021-pol2qm74	7074	10	and	and	CC
cord-015021-pol2qm74	7074	11	total	total	JJ
cord-015021-pol2qm74	7074	12	enteral	enteral	JJ
cord-015021-pol2qm74	7074	13	nutrition	nutrition	NN
cord-015021-pol2qm74	7074	14	(	(	-LRB-
cord-015021-pol2qm74	7074	15	EN	EN	NNP
cord-015021-pol2qm74	7074	16	)	)	-RRB-
cord-015021-pol2qm74	7074	17	group	group	NN
cord-015021-pol2qm74	7074	18	.	.	.
cord-015021-pol2qm74	7075	1	They	-PRON-	PRP
cord-015021-pol2qm74	7075	2	received	receive	VBD
cord-015021-pol2qm74	7075	3	identically	identically	RB
cord-015021-pol2qm74	7075	4	constituted	constitute	VBN
cord-015021-pol2qm74	7075	5	isocaloric	isocaloric	JJ
cord-015021-pol2qm74	7075	6	isonitxogenous	isonitxogenous	JJ
cord-015021-pol2qm74	7075	7	diets	diet	NNS
cord-015021-pol2qm74	7075	8	for	for	IN
cord-015021-pol2qm74	7075	9	seven	seven	CD
cord-015021-pol2qm74	7075	10	days	day	NNS
cord-015021-pol2qm74	7075	11	.	.	.
cord-015021-pol2qm74	7076	1	Animals	animal	NNS
cord-015021-pol2qm74	7076	2	were	be	VBD
cord-015021-pol2qm74	7076	3	then	then	RB
cord-015021-pol2qm74	7076	4	challenged	challenge	VBN
cord-015021-pol2qm74	7076	5	intraperitoneaUy	intraperitoneauy	NN
cord-015021-pol2qm74	7076	6	with	with	IN
cord-015021-pol2qm74	7076	7	3xl(Y	3xl(y	CD
cord-015021-pol2qm74	7076	8	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	7076	9	Coli	Coli	NNP
cord-015021-pol2qm74	7076	10	and	and	CC
cord-015021-pol2qm74	7076	11	survival	survival	NN
cord-015021-pol2qm74	7076	12	were	be	VBD
cord-015021-pol2qm74	7076	13	observed	observe	VBN
cord-015021-pol2qm74	7076	14	.	.	.
cord-015021-pol2qm74	7077	1	In	in	IN
cord-015021-pol2qm74	7077	2	other	other	JJ
cord-015021-pol2qm74	7077	3	experiments	experiment	NNS
cord-015021-pol2qm74	7077	4	,	,	,
cord-015021-pol2qm74	7077	5	they	-PRON-	PRP
cord-015021-pol2qm74	7077	6	were	be	VBD
cord-015021-pol2qm74	7077	7	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	7077	8	before	before	RB
cord-015021-pol2qm74	7077	9	and	and	CC
cord-015021-pol2qm74	7077	10	two	two	CD
cord-015021-pol2qm74	7077	11	hours	hour	NNS
cord-015021-pol2qm74	7077	12	after	after	IN
cord-015021-pol2qm74	7077	13	bacterial	bacterial	JJ
cord-015021-pol2qm74	7077	14	challenge	challenge	NN
cord-015021-pol2qm74	7077	15	.	.	.
cord-015021-pol2qm74	7078	1	Peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7078	2	cavity	cavity	NN
cord-015021-pol2qm74	7078	3	was	be	VBD
cord-015021-pol2qm74	7078	4	lavaged	lavage	VBN
cord-015021-pol2qm74	7078	5	with	with	IN
cord-015021-pol2qm74	7078	6	10ml	10ml	JJ
cord-015021-pol2qm74	7078	7	saline	saline	NN
cord-015021-pol2qm74	7078	8	and	and	CC
cord-015021-pol2qm74	7078	9	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7078	10	exudative	exudative	JJ
cord-015021-pol2qm74	7078	11	cells	cell	NNS
cord-015021-pol2qm74	7078	12	(	(	-LRB-
cord-015021-pol2qm74	7078	13	PEC	PEC	NNP
cord-015021-pol2qm74	7078	14	)	)	-RRB-
cord-015021-pol2qm74	7078	15	were	be	VBD
cord-015021-pol2qm74	7078	16	harvested	harvest	VBN
cord-015021-pol2qm74	7078	17	and	and	CC
cord-015021-pol2qm74	7078	18	cultured	culture	VBN
cord-015021-pol2qm74	7078	19	in	in	IN
cord-015021-pol2qm74	7078	20	vitro	vitro	FW
cord-015021-pol2qm74	7078	21	for	for	IN
cord-015021-pol2qm74	7078	22	24	24	CD
cord-015021-pol2qm74	7078	23	hours	hour	NNS
cord-015021-pol2qm74	7078	24	with	with	IN
cord-015021-pol2qm74	7078	25	and	and	CC
cord-015021-pol2qm74	7078	26	without	without	IN
cord-015021-pol2qm74	7078	27	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	7078	28	(	(	-LRB-
cord-015021-pol2qm74	7078	29	LPS	LPS	NNP
cord-015021-pol2qm74	7078	30	)	)	-RRB-
cord-015021-pol2qm74	7078	31	.	.	.
cord-015021-pol2qm74	7079	1	Colony	Colony	NNP
cord-015021-pol2qm74	7079	2	f(m	f(m	NNP
cord-015021-pol2qm74	7079	3	,	,	,
cord-015021-pol2qm74	7079	4	ning	ning	NN
cord-015021-pol2qm74	7079	5	units	unit	NNS
cord-015021-pol2qm74	7079	6	of	of	IN
cord-015021-pol2qm74	7079	7	bacteria	bacteria	NNS
cord-015021-pol2qm74	7079	8	(	(	-LRB-
cord-015021-pol2qm74	7079	9	CFU	CFU	NNP
cord-015021-pol2qm74	7079	10	-	-	HYPH
cord-015021-pol2qm74	7079	11	b	b	NNP
cord-015021-pol2qm74	7079	12	)	)	-RRB-
cord-015021-pol2qm74	7079	13	in	in	IN
cord-015021-pol2qm74	7079	14	the	the	DT
cord-015021-pol2qm74	7079	15	peritoncal	peritoncal	JJ
cord-015021-pol2qm74	7079	16	lavaged	lavaged	JJ
cord-015021-pol2qm74	7079	17	fluid	fluid	NN
cord-015021-pol2qm74	7079	18	(	(	-LRB-
cord-015021-pol2qm74	7079	19	PLF	PLF	NNP
cord-015021-pol2qm74	7079	20	)	)	-RRB-
cord-015021-pol2qm74	7079	21	were	be	VBD
cord-015021-pol2qm74	7079	22	determined	determine	VBN
cord-015021-pol2qm74	7079	23	and	and	CC
cord-015021-pol2qm74	7079	24	TNF	TNF	NNP
cord-015021-pol2qm74	7079	25	in	in	IN
cord-015021-pol2qm74	7079	26	the	the	DT
cord-015021-pol2qm74	7079	27	PLF	PLF	NNP
cord-015021-pol2qm74	7079	28	,	,	,
cord-015021-pol2qm74	7079	29	serum	serum	NN
cord-015021-pol2qm74	7079	30	and	and	CC
cord-015021-pol2qm74	7079	31	PEC	pec	NN
cord-015021-pol2qm74	7079	32	culture	culture	NN
cord-015021-pol2qm74	7079	33	supernal	supernal	JJ
cord-015021-pol2qm74	7079	34	,	,	,
cord-015021-pol2qm74	7079	35	ants	ant	NNS
cord-015021-pol2qm74	7079	36	were	be	VBD
cord-015021-pol2qm74	7079	37	measured	measure	VBN
cord-015021-pol2qm74	7079	38	by	by	IN
cord-015021-pol2qm74	7079	39	L929	l929	CD
cord-015021-pol2qm74	7079	40	bioassay	bioassay	NN
cord-015021-pol2qm74	7079	41	.	.	.
cord-015021-pol2qm74	7080	1	Twenty	twenty	CD
cord-015021-pol2qm74	7080	2	-	-	HYPH
cord-015021-pol2qm74	7080	3	fonr	fonr	NN
cord-015021-pol2qm74	7080	4	hour	hour	NN
cord-015021-pol2qm74	7080	5	survival	survival	NN
cord-015021-pol2qm74	7080	6	rate	rate	NN
cord-015021-pol2qm74	7080	7	in	in	IN
cord-015021-pol2qm74	7080	8	EN	EN	NNP
cord-015021-pol2qm74	7080	9	group	group	NN
cord-015021-pol2qm74	7080	10	was	be	VBD
cord-015021-pol2qm74	7080	11	significantly	significantly	RB
cord-015021-pol2qm74	7080	12	greater	great	JJR
cord-015021-pol2qm74	7080	13	than	than	IN
cord-015021-pol2qm74	7080	14	that	that	DT
cord-015021-pol2qm74	7080	15	in	in	IN
cord-015021-pol2qm74	7080	16	PN	PN	NNP
cord-015021-pol2qm74	7080	17	group	group	NN
cord-015021-pol2qm74	7080	18	(	(	-LRB-
cord-015021-pol2qm74	7080	19	60	60	CD
cord-015021-pol2qm74	7080	20	%	%	NN
cord-015021-pol2qm74	7080	21	vs	vs	IN
cord-015021-pol2qm74	7080	22	0	0	CD
cord-015021-pol2qm74	7080	23	%	%	NN
cord-015021-pol2qm74	7080	24	)	)	-RRB-
cord-015021-pol2qm74	7080	25	.	.	.
cord-015021-pol2qm74	7081	1	The	the	DT
cord-015021-pol2qm74	7081	2	data	datum	NNS
cord-015021-pol2qm74	7081	3	suggest	suggest	VBP
cord-015021-pol2qm74	7081	4	that	that	IN
cord-015021-pol2qm74	7081	5	local	local	JJ
cord-015021-pol2qm74	7081	6	immune	immune	JJ
cord-015021-pol2qm74	7081	7	responses	response	NNS
cord-015021-pol2qm74	7081	8	of	of	IN
cord-015021-pol2qm74	7081	9	PN	pn	NN
cord-015021-pol2qm74	7081	10	-	-	HYPH
cord-015021-pol2qm74	7081	11	treated	treat	VBN
cord-015021-pol2qm74	7081	12	animals	animal	NNS
cord-015021-pol2qm74	7081	13	may	may	MD
cord-015021-pol2qm74	7081	14	be	be	VB
cord-015021-pol2qm74	7081	15	depressed	depress	VBN
cord-015021-pol2qm74	7081	16	with	with	IN
cord-015021-pol2qm74	7081	17	consequent	consequent	JJ
cord-015021-pol2qm74	7081	18	disturbance	disturbance	NN
cord-015021-pol2qm74	7081	19	in	in	IN
cord-015021-pol2qm74	7081	20	the	the	DT
cord-015021-pol2qm74	7081	21	clearance	clearance	NN
cord-015021-pol2qm74	7081	22	of	of	IN
cord-015021-pol2qm74	7081	23	bacteria	bacteria	NNS
cord-015021-pol2qm74	7081	24	.	.	.
cord-015021-pol2qm74	7082	1	This	this	DT
cord-015021-pol2qm74	7082	2	may	may	MD
cord-015021-pol2qm74	7082	3	lead	lead	VB
cord-015021-pol2qm74	7082	4	to	to	IN
cord-015021-pol2qm74	7082	5	a	a	DT
cord-015021-pol2qm74	7082	6	greater	great	JJR
cord-015021-pol2qm74	7082	7	systemic	systemic	JJ
cord-015021-pol2qm74	7082	8	cytokine	cytokine	NN
cord-015021-pol2qm74	7082	9	response	response	NN
cord-015021-pol2qm74	7082	10	and	and	CC
cord-015021-pol2qm74	7082	11	resulting	result	VBG
cord-015021-pol2qm74	7082	12	in	in	IN
cord-015021-pol2qm74	7082	13	a	a	DT
cord-015021-pol2qm74	7082	14	poor	poor	JJ
cord-015021-pol2qm74	7082	15	survival	survival	NN
cord-015021-pol2qm74	7082	16	after	after	IN
cord-015021-pol2qm74	7082	17	bacterial	bacterial	JJ
cord-015021-pol2qm74	7082	18	challenge	challenge	NN
cord-015021-pol2qm74	7082	19	in	in	IN
cord-015021-pol2qm74	7082	20	PN	PN	NNP
cord-015021-pol2qm74	7082	21	group	group	NN
cord-015021-pol2qm74	7082	22	.	.	.
cord-015021-pol2qm74	7083	1	The	the	DT
cord-015021-pol2qm74	7083	2	effects	effect	NNS
cord-015021-pol2qm74	7083	3	of	of	IN
cord-015021-pol2qm74	7083	4	intragastfic	intragastfic	NN
cord-015021-pol2qm74	7083	5	tube	tube	NN
cord-015021-pol2qm74	7083	6	feeding	feeding	NN
cord-015021-pol2qm74	7083	7	of	of	IN
cord-015021-pol2qm74	7083	8	diets	diet	NNS
cord-015021-pol2qm74	7083	9	enriched	enrich	VBN
cord-015021-pol2qm74	7083	10	with	with	IN
cord-015021-pol2qm74	7083	11	m-6	m-6	NNP
cord-015021-pol2qm74	7083	12	polyunsaturated	polyunsaturated	JJ
cord-015021-pol2qm74	7083	13	fatty	fatty	JJ
cord-015021-pol2qm74	7083	14	acids	acid	NNS
cord-015021-pol2qm74	7083	15	(	(	-LRB-
cord-015021-pol2qm74	7083	16	PUFA	PUFA	NNP
cord-015021-pol2qm74	7083	17	)	)	-RRB-
cord-015021-pol2qm74	7083	18	from	from	IN
cord-015021-pol2qm74	7083	19	safflower	safflower	NN
cord-015021-pol2qm74	7083	20	oil	oil	NN
cord-015021-pol2qm74	7083	21	(	(	-LRB-
cord-015021-pol2qm74	7083	22	SO	so	RB
cord-015021-pol2qm74	7083	23	)	)	-RRB-
cord-015021-pol2qm74	7083	24	or	or	CC
cord-015021-pol2qm74	7083	25	(	(	-LRB-
cord-015021-pol2qm74	7083	26	o-3	o-3	JJ
cord-015021-pol2qm74	7083	27	PUFA	PUFA	NNP
cord-015021-pol2qm74	7083	28	from	from	IN
cord-015021-pol2qm74	7083	29	menhaden	menhaden	NN
cord-015021-pol2qm74	7083	30	oil	oil	NN
cord-015021-pol2qm74	7083	31	(	(	-LRB-
cord-015021-pol2qm74	7083	32	MO	MO	NNP
cord-015021-pol2qm74	7083	33	)	)	-RRB-
cord-015021-pol2qm74	7083	34	on	on	IN
cord-015021-pol2qm74	7083	35	eicosanoid	eicosanoid	JJ
cord-015021-pol2qm74	7083	36	production	production	NN
cord-015021-pol2qm74	7083	37	,	,	,
cord-015021-pol2qm74	7083	38	and	and	CC
cord-015021-pol2qm74	7083	39	onthe	onthe	JJ
cord-015021-pol2qm74	7083	40	membrane	membrane	NN
cord-015021-pol2qm74	7083	41	phospholipid	phospholipid	NN
cord-015021-pol2qm74	7083	42	fatty	fatty	JJ
cord-015021-pol2qm74	7083	43	acid	acid	NN
cord-015021-pol2qm74	7083	44	composition	composition	NN
cord-015021-pol2qm74	7083	45	were	be	VBD
cord-015021-pol2qm74	7083	46	investigated	investigate	VBN
cord-015021-pol2qm74	7083	47	in	in	IN
cord-015021-pol2qm74	7083	48	a	a	DT
cord-015021-pol2qm74	7083	49	severe	severe	JJ
cord-015021-pol2qm74	7083	50	acute	acute	JJ
cord-015021-pol2qm74	7083	51	septic	septic	JJ
cord-015021-pol2qm74	7083	52	shock	shock	NN
cord-015021-pol2qm74	7083	53	model	model	NN
cord-015021-pol2qm74	7083	54	.	.	.
cord-015021-pol2qm74	7084	1	The	the	DT
cord-015021-pol2qm74	7084	2	percent	percent	NN
cord-015021-pol2qm74	7084	3	calories	calorie	NNS
cord-015021-pol2qm74	7084	4	from	from	IN
cord-015021-pol2qm74	7084	5	fat	fat	NN
cord-015021-pol2qm74	7084	6	maintained	maintain	VBN
cord-015021-pol2qm74	7084	7	at	at	IN
cord-015021-pol2qm74	7084	8	30	30	CD
cord-015021-pol2qm74	7084	9	%	%	NN
cord-015021-pol2qm74	7084	10	in	in	IN
cord-015021-pol2qm74	7084	11	the	the	DT
cord-015021-pol2qm74	7084	12	diets	diet	NNS
cord-015021-pol2qm74	7084	13	was	be	VBD
cord-015021-pol2qm74	7084	14	adjusted	adjust	VBN
cord-015021-pol2qm74	7084	15	to	to	TO
cord-015021-pol2qm74	7084	16	provide	provide	VB
cord-015021-pol2qm74	7084	17	10	10	CD
cord-015021-pol2qm74	7084	18	%	%	NN
cord-015021-pol2qm74	7084	19	each	each	DT
cord-015021-pol2qm74	7084	20	of	of	IN
cord-015021-pol2qm74	7084	21	saturated	saturate	VBN
cord-015021-pol2qm74	7084	22	,	,	,
cord-015021-pol2qm74	7084	23	monounsaturated	monounsaturated	JJ
cord-015021-pol2qm74	7084	24	,	,	,
cord-015021-pol2qm74	7084	25	and	and	CC
cord-015021-pol2qm74	7084	26	PUFA	PUFA	NNP
cord-015021-pol2qm74	7084	27	using	use	VBG
cord-015021-pol2qm74	7084	28	olive	olive	NN
cord-015021-pol2qm74	7084	29	oil	oil	NN
cord-015021-pol2qm74	7084	30	and	and	CC
cord-015021-pol2qm74	7084	31	palm	palm	NN
cord-015021-pol2qm74	7084	32	oil	oil	NN
cord-015021-pol2qm74	7084	33	as	as	IN
cord-015021-pol2qm74	7084	34	filler	filler	NN
cord-015021-pol2qm74	7084	35	fats	fat	NNS
cord-015021-pol2qm74	7084	36	.	.	.
cord-015021-pol2qm74	7085	1	After	after	IN
cord-015021-pol2qm74	7085	2	feeding	feed	VBG
cord-015021-pol2qm74	7085	3	for	for	IN
cord-015021-pol2qm74	7085	4	5	5	CD
cord-015021-pol2qm74	7085	5	days	day	NNS
cord-015021-pol2qm74	7085	6	,	,	,
cord-015021-pol2qm74	7085	7	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	7085	8	(	(	-LRB-
cord-015021-pol2qm74	7085	9	LPS	LPS	NNP
cord-015021-pol2qm74	7085	10	,	,	,
cord-015021-pol2qm74	7085	11	9mg/100	9mg/100	CD
cord-015021-pol2qm74	7085	12	g	g	NN
cord-015021-pol2qm74	7085	13	)	)	-RRB-
cord-015021-pol2qm74	7085	14	was	be	VBD
cord-015021-pol2qm74	7085	15	injected	inject	VBN
cord-015021-pol2qm74	7085	16	through	through	IN
cord-015021-pol2qm74	7085	17	the	the	DT
cord-015021-pol2qm74	7085	18	tail	tail	NN
cord-015021-pol2qm74	7085	19	vein	vein	NN
cord-015021-pol2qm74	7085	20	.	.	.
cord-015021-pol2qm74	7086	1	The	the	DT
cord-015021-pol2qm74	7086	2	percent	percent	NN
cord-015021-pol2qm74	7086	3	of	of	IN
cord-015021-pol2qm74	7086	4	animals	animal	NNS
cord-015021-pol2qm74	7086	5	surviving	survive	VBG
cord-015021-pol2qm74	7086	6	in	in	IN
cord-015021-pol2qm74	7086	7	the	the	DT
cord-015021-pol2qm74	7086	8	MO	MO	NNP
cord-015021-pol2qm74	7086	9	group	group	NN
cord-015021-pol2qm74	7086	10	was	be	VBD
cord-015021-pol2qm74	7086	11	67	67	CD
cord-015021-pol2qm74	7086	12	%	%	NN
cord-015021-pol2qm74	7086	13	(	(	-LRB-
cord-015021-pol2qm74	7086	14	14/21	14/21	CD
cord-015021-pol2qm74	7086	15	)	)	-RRB-
cord-015021-pol2qm74	7086	16	,	,	,
cord-015021-pol2qm74	7086	17	and	and	CC
cord-015021-pol2qm74	7086	18	did	do	VBD
cord-015021-pol2qm74	7086	19	not	not	RB
cord-015021-pol2qm74	7086	20	differ	differ	VB
cord-015021-pol2qm74	7086	21	significantly	significantly	RB
cord-015021-pol2qm74	7086	22	compared	compare	VBN
cord-015021-pol2qm74	7086	23	to	to	IN
cord-015021-pol2qm74	7086	24	57	57	CD
cord-015021-pol2qm74	7086	25	%	%	NN
cord-015021-pol2qm74	7086	26	(	(	-LRB-
cord-015021-pol2qm74	7086	27	12/21	12/21	CD
cord-015021-pol2qm74	7086	28	)	)	-RRB-
cord-015021-pol2qm74	7086	29	in	in	IN
cord-015021-pol2qm74	7086	30	the	the	DT
cord-015021-pol2qm74	7086	31	SO	so	JJ
cord-015021-pol2qm74	7086	32	group	group	NN
cord-015021-pol2qm74	7086	33	.	.	.
cord-015021-pol2qm74	7087	1	The	the	DT
cord-015021-pol2qm74	7087	2	plasma	plasma	NN
cord-015021-pol2qm74	7087	3	concentrations	concentration	NNS
cord-015021-pol2qm74	7087	4	of	of	IN
cord-015021-pol2qm74	7087	5	TNF	TNF	NNP
cord-015021-pol2qm74	7087	6	ct	ct	NNP
cord-015021-pol2qm74	7087	7	for	for	IN
cord-015021-pol2qm74	7087	8	the	the	DT
cord-015021-pol2qm74	7087	9	groups	group	NNS
cord-015021-pol2qm74	7087	10	of	of	IN
cord-015021-pol2qm74	7087	11	animals	animal	NNS
cord-015021-pol2qm74	7087	12	fed	feed	VBN
cord-015021-pol2qm74	7087	13	SO	so	RB
cord-015021-pol2qm74	7088	1	(	(	-LRB-
cord-015021-pol2qm74	7088	2	1.2	1.2	CD
cord-015021-pol2qm74	7088	3	+	+	SYM
cord-015021-pol2qm74	7088	4	3.0	3.0	CD
cord-015021-pol2qm74	7088	5	ng	ng	NN
cord-015021-pol2qm74	7088	6	/	/	SYM
cord-015021-pol2qm74	7088	7	ml	ml	NN
cord-015021-pol2qm74	7088	8	)	)	-RRB-
cord-015021-pol2qm74	7088	9	and	and	CC
cord-015021-pol2qm74	7088	10	those	those	DT
cord-015021-pol2qm74	7088	11	fed	fed	NNP
cord-015021-pol2qm74	7088	12	MO	MO	NNP
cord-015021-pol2qm74	7088	13	(	(	-LRB-
cord-015021-pol2qm74	7088	14	1.8	1.8	CD
cord-015021-pol2qm74	7088	15	+	+	SYM
cord-015021-pol2qm74	7088	16	1.1	1.1	CD
cord-015021-pol2qm74	7088	17	)	)	-RRB-
cord-015021-pol2qm74	7088	18	did	do	VBD
cord-015021-pol2qm74	7088	19	not	not	RB
cord-015021-pol2qm74	7088	20	differ	differ	VB
cord-015021-pol2qm74	7088	21	significantly	significantly	RB
cord-015021-pol2qm74	7088	22	.	.	.
cord-015021-pol2qm74	7089	1	The	the	DT
cord-015021-pol2qm74	7089	2	levels	level	NNS
cord-015021-pol2qm74	7089	3	of	of	IN
cord-015021-pol2qm74	7089	4	prostaglandin(PG)E2	prostaglandin(PG)E2	NNP
cord-015021-pol2qm74	7089	5	,	,	,
cord-015021-pol2qm74	7089	6	6-Keto	6-keto	CD
cord-015021-pol2qm74	7089	7	-	-	HYPH
cord-015021-pol2qm74	7089	8	PGFlc~	pgflc~	NN
cord-015021-pol2qm74	7089	9	and	and	CC
cord-015021-pol2qm74	7089	10	tumor	tumor	NN
cord-015021-pol2qm74	7089	11	necrosis	necrosis	NN
cord-015021-pol2qm74	7089	12	factor	factor	NN
cord-015021-pol2qm74	7089	13	-	-	HYPH
cord-015021-pol2qm74	7089	14	ct	ct	NN
cord-015021-pol2qm74	7090	1	(	(	-LRB-
cord-015021-pol2qm74	7090	2	TNF	TNF	NNP
cord-015021-pol2qm74	7090	3	-	-	HYPH
cord-015021-pol2qm74	7090	4	c	c	NNP
cord-015021-pol2qm74	7090	5	0	0	CD
cord-015021-pol2qm74	7090	6	were	be	VBD
cord-015021-pol2qm74	7090	7	determined	determine	VBN
cord-015021-pol2qm74	7090	8	90	90	CD
cord-015021-pol2qm74	7090	9	min	min	NN
cord-015021-pol2qm74	7090	10	after	after	IN
cord-015021-pol2qm74	7090	11	LPS	LPS	NNP
cord-015021-pol2qm74	7090	12	injection	injection	NN
cord-015021-pol2qm74	7090	13	.	.	.
cord-015021-pol2qm74	7091	1	The	the	DT
cord-015021-pol2qm74	7091	2	fatty	fatty	JJ
cord-015021-pol2qm74	7091	3	composition	composition	NN
cord-015021-pol2qm74	7091	4	(	(	-LRB-
cord-015021-pol2qm74	7091	5	relative	relative	JJ
cord-015021-pol2qm74	7091	6	mole%	mole%	NN
cord-015021-pol2qm74	7091	7	)	)	-RRB-
cord-015021-pol2qm74	7091	8	of	of	IN
cord-015021-pol2qm74	7091	9	the	the	DT
cord-015021-pol2qm74	7091	10	liver	liver	NN
cord-015021-pol2qm74	7091	11	was	be	VBD
cord-015021-pol2qm74	7091	12	determined	determine	VBN
cord-015021-pol2qm74	7091	13	before	before	IN
cord-015021-pol2qm74	7091	14	(	(	-LRB-
cord-015021-pol2qm74	7091	15	LPS-	LPS-	NNP
cord-015021-pol2qm74	7091	16	)	)	-RRB-
cord-015021-pol2qm74	7091	17	and	and	CC
cord-015021-pol2qm74	7091	18	3h	3h	CD
cord-015021-pol2qm74	7091	19	after	after	IN
cord-015021-pol2qm74	7091	20	the	the	DT
cord-015021-pol2qm74	7091	21	LPS	LPS	NNP
cord-015021-pol2qm74	7091	22	administration	administration	NN
cord-015021-pol2qm74	7091	23	(	(	-LRB-
cord-015021-pol2qm74	7091	24	LPS+	LPS+	NNP
cord-015021-pol2qm74	7091	25	)	)	-RRB-
cord-015021-pol2qm74	7091	26	.	.	.
cord-015021-pol2qm74	7092	1	The	the	DT
cord-015021-pol2qm74	7092	2	data	datum	NNS
cord-015021-pol2qm74	7092	3	(	(	-LRB-
cord-015021-pol2qm74	7092	4	mean_+SD	mean_+sd	RB
cord-015021-pol2qm74	7092	5	;	;	:
cord-015021-pol2qm74	7092	6	n=6	n=6	NNP
cord-015021-pol2qm74	7092	7	)	)	-RRB-
cord-015021-pol2qm74	7092	8	are	be	VBP
cord-015021-pol2qm74	7092	9	as	as	IN
cord-015021-pol2qm74	7092	10	follows	follow	NNS
cord-015021-pol2qm74	7092	11	.	.	.
cord-015021-pol2qm74	7093	1	Group	group	NN
cord-015021-pol2qm74	7094	1	These	these	DT
cord-015021-pol2qm74	7094	2	data	datum	NNS
cord-015021-pol2qm74	7094	3	indicate	indicate	VBP
cord-015021-pol2qm74	7094	4	that	that	IN
cord-015021-pol2qm74	7094	5	a	a	DT
cord-015021-pol2qm74	7094	6	marked	marked	JJ
cord-015021-pol2qm74	7094	7	reduction	reduction	NN
cord-015021-pol2qm74	7094	8	in	in	IN
cord-015021-pol2qm74	7094	9	the	the	DT
cord-015021-pol2qm74	7094	10	plasma	plasma	NN
cord-015021-pol2qm74	7094	11	levels	level	NNS
cord-015021-pol2qm74	7094	12	of	of	IN
cord-015021-pol2qm74	7094	13	POE2	POE2	NNP
cord-015021-pol2qm74	7094	14	and	and	CC
cord-015021-pol2qm74	7094	15	6-Keto	6-keto	CD
cord-015021-pol2qm74	7094	16	-	-	HYPH
cord-015021-pol2qm74	7094	17	PGFlct	PGFlct	NNP
cord-015021-pol2qm74	7094	18	for	for	IN
cord-015021-pol2qm74	7094	19	rats	rat	NNS
cord-015021-pol2qm74	7094	20	fed	fed	NNP
cord-015021-pol2qm74	7094	21	MO	MO	NNP
cord-015021-pol2qm74	7094	22	diet	diet	NN
cord-015021-pol2qm74	7094	23	was	be	VBD
cord-015021-pol2qm74	7094	24	associated	associate	VBN
cord-015021-pol2qm74	7094	25	with	with	IN
cord-015021-pol2qm74	7094	26	a	a	DT
cord-015021-pol2qm74	7094	27	reduction	reduction	NN
cord-015021-pol2qm74	7094	28	in	in	IN
cord-015021-pol2qm74	7094	29	AA	AA	NNP
cord-015021-pol2qm74	7094	30	which	which	WDT
cord-015021-pol2qm74	7094	31	was	be	VBD
cord-015021-pol2qm74	7094	32	displaced	displace	VBN
cord-015021-pol2qm74	7094	33	by	by	IN
cord-015021-pol2qm74	7094	34	EPA	EPA	NNP
cord-015021-pol2qm74	7094	35	in	in	IN
cord-015021-pol2qm74	7094	36	the	the	DT
cord-015021-pol2qm74	7094	37	membrane	membrane	NN
cord-015021-pol2qm74	7094	38	phospholipids	phospholipid	NNS
cord-015021-pol2qm74	7094	39	.	.	.
cord-015021-pol2qm74	7095	1	Further	further	RB
cord-015021-pol2qm74	7095	2	,	,	,
cord-015021-pol2qm74	7095	3	in	in	IN
cord-015021-pol2qm74	7095	4	these	these	DT
cord-015021-pol2qm74	7095	5	rats	rat	NNS
cord-015021-pol2qm74	7095	6	,	,	,
cord-015021-pol2qm74	7095	7	we	-PRON-	PRP
cord-015021-pol2qm74	7095	8	observed	observe	VBD
cord-015021-pol2qm74	7095	9	that	that	IN
cord-015021-pol2qm74	7095	10	there	there	EX
cord-015021-pol2qm74	7095	11	was	be	VBD
cord-015021-pol2qm74	7095	12	a	a	DT
cord-015021-pol2qm74	7095	13	2.8	2.8	CD
cord-015021-pol2qm74	7095	14	%	%	NN
cord-015021-pol2qm74	7095	15	reduction	reduction	NN
cord-015021-pol2qm74	7095	16	in	in	IN
cord-015021-pol2qm74	7095	17	the	the	DT
cord-015021-pol2qm74	7095	18	percent	percent	NN
cord-015021-pol2qm74	7095	19	of	of	IN
cord-015021-pol2qm74	7095	20	EPA	EPA	NNP
cord-015021-pol2qm74	7095	21	following	follow	VBG
cord-015021-pol2qm74	7095	22	LPS	LPS	NNP
cord-015021-pol2qm74	7095	23	challenge	challenge	NN
cord-015021-pol2qm74	7095	24	compared	compare	VBN
cord-015021-pol2qm74	7095	25	to	to	IN
cord-015021-pol2qm74	7095	26	the	the	DT
cord-015021-pol2qm74	7095	27	basal	basal	NN
cord-015021-pol2qm74	7095	28	levels	level	NNS
cord-015021-pol2qm74	7095	29	.	.	.
cord-015021-pol2qm74	7096	1	However	however	RB
cord-015021-pol2qm74	7096	2	,	,	,
cord-015021-pol2qm74	7096	3	for	for	IN
cord-015021-pol2qm74	7096	4	the	the	DT
cord-015021-pol2qm74	7096	5	group	group	NN
cord-015021-pol2qm74	7096	6	of	of	IN
cord-015021-pol2qm74	7096	7	rats	rat	NNS
cord-015021-pol2qm74	7096	8	maintained	maintain	VBD
cord-015021-pol2qm74	7096	9	on	on	IN
cord-015021-pol2qm74	7096	10	SO	SO	NNP
cord-015021-pol2qm74	7096	11	diet	diet	NN
cord-015021-pol2qm74	7096	12	,	,	,
cord-015021-pol2qm74	7096	13	the	the	DT
cord-015021-pol2qm74	7096	14	liver	liver	NN
cord-015021-pol2qm74	7096	15	membrane	membrane	NN
cord-015021-pol2qm74	7096	16	phospholipid	phospholipid	NN
cord-015021-pol2qm74	7096	17	fatty	fatty	JJ
cord-015021-pol2qm74	7096	18	acid	acid	NN
cord-015021-pol2qm74	7096	19	composition	composition	NN
cord-015021-pol2qm74	7096	20	before	before	IN
cord-015021-pol2qm74	7096	21	and	and	CC
cord-015021-pol2qm74	7096	22	after	after	IN
cord-015021-pol2qm74	7096	23	LPS	LPS	NNP
cord-015021-pol2qm74	7096	24	administration	administration	NN
cord-015021-pol2qm74	7096	25	was	be	VBD
cord-015021-pol2qm74	7096	26	unaltered	unaltered	JJ
cord-015021-pol2qm74	7096	27	.	.	.
cord-015021-pol2qm74	7097	1	These	these	DT
cord-015021-pol2qm74	7097	2	finding	finding	NN
cord-015021-pol2qm74	7097	3	suggest	suggest	VBP
cord-015021-pol2qm74	7097	4	that	that	IN
cord-015021-pol2qm74	7097	5	although	although	IN
cord-015021-pol2qm74	7097	6	a	a	DT
cord-015021-pol2qm74	7097	7	reduction	reduction	NN
cord-015021-pol2qm74	7097	8	in	in	IN
cord-015021-pol2qm74	7097	9	AA	AA	NNP
cord-015021-pol2qm74	7097	10	was	be	VBD
cord-015021-pol2qm74	7097	11	associated	associate	VBN
cord-015021-pol2qm74	7097	12	with	with	IN
cord-015021-pol2qm74	7097	13	a	a	DT
cord-015021-pol2qm74	7097	14	decrease	decrease	NN
cord-015021-pol2qm74	7097	15	in	in	IN
cord-015021-pol2qm74	7097	16	the	the	DT
cord-015021-pol2qm74	7097	17	production	production	NN
cord-015021-pol2qm74	7097	18	of	of	IN
cord-015021-pol2qm74	7097	19	pro	pro	JJ
cord-015021-pol2qm74	7097	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7097	21	eicosanoids	eicosanoid	NNS
cord-015021-pol2qm74	7097	22	after	after	IN
cord-015021-pol2qm74	7097	23	5	5	CD
cord-015021-pol2qm74	7097	24	days	day	NNS
cord-015021-pol2qm74	7097	25	of	of	IN
cord-015021-pol2qm74	7097	26	continuous	continuous	JJ
cord-015021-pol2qm74	7097	27	MO	MO	NNP
cord-015021-pol2qm74	7097	28	feeding	feeding	NN
cord-015021-pol2qm74	7097	29	,	,	,
cord-015021-pol2qm74	7097	30	there	there	EX
cord-015021-pol2qm74	7097	31	was	be	VBD
cord-015021-pol2qm74	7097	32	no	no	DT
cord-015021-pol2qm74	7097	33	marked	marked	JJ
cord-015021-pol2qm74	7097	34	effect	effect	NN
cord-015021-pol2qm74	7097	35	on	on	IN
cord-015021-pol2qm74	7097	36	the	the	DT
cord-015021-pol2qm74	7097	37	survival	survival	NN
cord-015021-pol2qm74	7097	38	following	follow	VBG
cord-015021-pol2qm74	7097	39	LPS	LPS	NNP
cord-015021-pol2qm74	7097	40	challenge	challenge	NN
cord-015021-pol2qm74	7097	41	.	.	.
cord-015021-pol2qm74	7098	1	Animal	animal	NN
cord-015021-pol2qm74	7098	2	models	model	NNS
cord-015021-pol2qm74	7098	3	have	have	VBP
cord-015021-pol2qm74	7098	4	been	be	VBN
cord-015021-pol2qm74	7098	5	used	use	VBN
cord-015021-pol2qm74	7098	6	to	to	TO
cord-015021-pol2qm74	7098	7	examine	examine	VB
cord-015021-pol2qm74	7098	8	the	the	DT
cord-015021-pol2qm74	7098	9	effects	effect	NNS
cord-015021-pol2qm74	7098	10	of	of	IN
cord-015021-pol2qm74	7098	11	various	various	JJ
cord-015021-pol2qm74	7098	12	nutrients	nutrient	NNS
cord-015021-pol2qm74	7098	13	and	and	CC
cord-015021-pol2qm74	7098	14	nutrient	nutrient	NN
cord-015021-pol2qm74	7098	15	combinations	combination	NNS
cord-015021-pol2qm74	7098	16	upon	upon	IN
cord-015021-pol2qm74	7098	17	the	the	DT
cord-015021-pol2qm74	7098	18	immune	immune	JJ
cord-015021-pol2qm74	7098	19	system	system	NN
cord-015021-pol2qm74	7098	20	.	.	.
cord-015021-pol2qm74	7099	1	We	-PRON-	PRP
cord-015021-pol2qm74	7099	2	studied	study	VBD
cord-015021-pol2qm74	7099	3	the	the	DT
cord-015021-pol2qm74	7099	4	effects	effect	NNS
cord-015021-pol2qm74	7099	5	of	of	IN
cord-015021-pol2qm74	7099	6	standard	standard	NN
cord-015021-pol2qm74	7099	7	and	and	CC
cord-015021-pol2qm74	7099	8	specialized	specialized	JJ
cord-015021-pol2qm74	7099	9	enteral	enteral	JJ
cord-015021-pol2qm74	7099	10	formulations	formulation	NNS
cord-015021-pol2qm74	7099	11	on	on	IN
cord-015021-pol2qm74	7099	12	the	the	DT
cord-015021-pol2qm74	7099	13	response	response	NN
cord-015021-pol2qm74	7099	14	of	of	IN
cord-015021-pol2qm74	7099	15	mice	mouse	NNS
cord-015021-pol2qm74	7099	16	to	to	IN
cord-015021-pol2qm74	7099	17	infectious	infectious	JJ
cord-015021-pol2qm74	7099	18	challenge	challenge	NN
cord-015021-pol2qm74	7099	19	with	with	IN
cord-015021-pol2qm74	7099	20	Listeria	Listeria	NNP
cord-015021-pol2qm74	7099	21	monocytogenes	monocytogenes	NNP
cord-015021-pol2qm74	7099	22	,	,	,
cord-015021-pol2qm74	7099	23	Influenza	Influenza	NNP
cord-015021-pol2qm74	7099	24	A	A	NNP
cord-015021-pol2qm74	7099	25	or	or	CC
cord-015021-pol2qm74	7099	26	Candida	Candida	NNP
cord-015021-pol2qm74	7099	27	albicans	albican	NNS
cord-015021-pol2qm74	7099	28	in	in	IN
cord-015021-pol2qm74	7099	29	order	order	NN
cord-015021-pol2qm74	7099	30	to	to	TO
cord-015021-pol2qm74	7099	31	test	test	VB
cord-015021-pol2qm74	7099	32	the	the	DT
cord-015021-pol2qm74	7099	33	efficacy	efficacy	NN
cord-015021-pol2qm74	7099	34	of	of	IN
cord-015021-pol2qm74	7099	35	specialized	specialized	JJ
cord-015021-pol2qm74	7099	36	ingredients	ingredient	NNS
cord-015021-pol2qm74	7099	37	.	.	.
cord-015021-pol2qm74	7100	1	CF-1	CF-1	NNP
cord-015021-pol2qm74	7101	1	outhred	outhre	VBN
cord-015021-pol2qm74	7101	2	female	female	JJ
cord-015021-pol2qm74	7101	3	mice	mouse	NNS
cord-015021-pol2qm74	7101	4	(	(	-LRB-
cord-015021-pol2qm74	7101	5	12	12	CD
cord-015021-pol2qm74	7101	6	-	-	SYM
cord-015021-pol2qm74	7101	7	15	15	CD
cord-015021-pol2qm74	7101	8	g	g	NN
cord-015021-pol2qm74	7101	9	)	)	-RRB-
cord-015021-pol2qm74	7101	10	were	be	VBD
cord-015021-pol2qm74	7101	11	fed	feed	VBN
cord-015021-pol2qm74	7101	12	Purina	Purina	NNP
cord-015021-pol2qm74	7101	13	#	#	NN
cord-015021-pol2qm74	7101	14	5002	5002	CD
cord-015021-pol2qm74	7101	15	chow	chow	NN
cord-015021-pol2qm74	7101	16	,	,	,
cord-015021-pol2qm74	7101	17	commercially	commercially	RB
cord-015021-pol2qm74	7101	18	available	available	JJ
cord-015021-pol2qm74	7101	19	Osmolite	Osmolite	NNP
cord-015021-pol2qm74	7101	20	HN	HN	NNP
cord-015021-pol2qm74	7102	1	®	®	VB
cord-015021-pol2qm74	7102	2	,	,	,
cord-015021-pol2qm74	7102	3	Perative	Perative	NNP
cord-015021-pol2qm74	7102	4	®	®	VBP
cord-015021-pol2qm74	7102	5	or	or	CC
cord-015021-pol2qm74	7102	6	Impact	Impact	NNP
cord-015021-pol2qm74	7102	7	*	*	NFP
cord-015021-pol2qm74	7102	8	.	.	.
cord-015021-pol2qm74	7102	9	Mortality	mortality	NN
cord-015021-pol2qm74	7102	10	and	and	CC
cord-015021-pol2qm74	7102	11	tissue	tissue	NN
cord-015021-pol2qm74	7102	12	burden	burden	NN
cord-015021-pol2qm74	7102	13	of	of	IN
cord-015021-pol2qm74	7102	14	pathogen	pathogen	NN
cord-015021-pol2qm74	7102	15	were	be	VBD
cord-015021-pol2qm74	7102	16	examined	examine	VBN
cord-015021-pol2qm74	7102	17	during	during	IN
cord-015021-pol2qm74	7102	18	the	the	DT
cord-015021-pol2qm74	7102	19	21	21	CD
cord-015021-pol2qm74	7102	20	d	d	NN
cord-015021-pol2qm74	7102	21	period	period	NN
cord-015021-pol2qm74	7102	22	following	follow	VBG
cord-015021-pol2qm74	7102	23	induced	induce	VBN
cord-015021-pol2qm74	7102	24	infection	infection	NN
cord-015021-pol2qm74	7102	25	.	.	.
cord-015021-pol2qm74	7103	1	The	the	DT
cord-015021-pol2qm74	7103	2	results	result	NNS
cord-015021-pol2qm74	7103	3	indicate	indicate	VBP
cord-015021-pol2qm74	7103	4	that	that	IN
cord-015021-pol2qm74	7103	5	there	there	EX
cord-015021-pol2qm74	7103	6	were	be	VBD
cord-015021-pol2qm74	7103	7	no	no	DT
cord-015021-pol2qm74	7103	8	differences	difference	NNS
cord-015021-pol2qm74	7103	9	between	between	IN
cord-015021-pol2qm74	7103	10	the	the	DT
cord-015021-pol2qm74	7103	11	groups	group	NNS
cord-015021-pol2qm74	7103	12	fed	feed	VBD
cord-015021-pol2qm74	7103	13	the	the	DT
cord-015021-pol2qm74	7103	14	liquid	liquid	JJ
cord-015021-pol2qm74	7103	15	formulas	formula	NNS
cord-015021-pol2qm74	7103	16	with	with	IN
cord-015021-pol2qm74	7103	17	regards	regard	NNS
cord-015021-pol2qm74	7103	18	to	to	TO
cord-015021-pol2qm74	7103	19	mean	mean	VB
cord-015021-pol2qm74	7103	20	survival	survival	NN
cord-015021-pol2qm74	7103	21	time	time	NN
cord-015021-pol2qm74	7103	22	or	or	CC
cord-015021-pol2qm74	7103	23	%	%	NN
cord-015021-pol2qm74	7103	24	survivors	survivor	NNS
cord-015021-pol2qm74	7103	25	in	in	IN
cord-015021-pol2qm74	7103	26	these	these	DT
cord-015021-pol2qm74	7103	27	models	model	NNS
cord-015021-pol2qm74	7103	28	of	of	IN
cord-015021-pol2qm74	7103	29	infection	infection	NN
cord-015021-pol2qm74	7103	30	.	.	.
cord-015021-pol2qm74	7104	1	Examination	examination	NN
cord-015021-pol2qm74	7104	2	of	of	IN
cord-015021-pol2qm74	7104	3	spleens	spleen	NNS
cord-015021-pol2qm74	7104	4	in	in	IN
cord-015021-pol2qm74	7104	5	the	the	DT
cord-015021-pol2qm74	7104	6	groups	group	NNS
cord-015021-pol2qm74	7104	7	challenged	challenge	VBN
cord-015021-pol2qm74	7104	8	with	with	IN
cord-015021-pol2qm74	7104	9	L.	L.	NNP
cord-015021-pol2qm74	7104	10	monocytogenes	monocytogene	NNS
cord-015021-pol2qm74	7104	11	and	and	CC
cord-015021-pol2qm74	7104	12	kidneys	kidney	NNS
cord-015021-pol2qm74	7104	13	in	in	IN
cord-015021-pol2qm74	7104	14	the	the	DT
cord-015021-pol2qm74	7104	15	groups	group	NNS
cord-015021-pol2qm74	7104	16	challenged	challenge	VBN
cord-015021-pol2qm74	7104	17	with	with	IN
cord-015021-pol2qm74	7104	18	C.	C.	NNP
cord-015021-pol2qm74	7104	19	albicans	albican	NNS
cord-015021-pol2qm74	7105	1	revealed	reveal	VBD
cord-015021-pol2qm74	7105	2	no	no	DT
cord-015021-pol2qm74	7105	3	differences	difference	NNS
cord-015021-pol2qm74	7105	4	in	in	IN
cord-015021-pol2qm74	7105	5	tissue	tissue	NN
cord-015021-pol2qm74	7105	6	burden	burden	NN
cord-015021-pol2qm74	7105	7	of	of	IN
cord-015021-pol2qm74	7105	8	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	7105	9	organisms	organism	NNS
cord-015021-pol2qm74	7105	10	.	.	.
cord-015021-pol2qm74	7106	1	Alterations	alteration	NNS
cord-015021-pol2qm74	7106	2	in	in	IN
cord-015021-pol2qm74	7106	3	the	the	DT
cord-015021-pol2qm74	7106	4	length	length	NN
cord-015021-pol2qm74	7106	5	of	of	IN
cord-015021-pol2qm74	7106	6	pre	pre	NN
cord-015021-pol2qm74	7106	7	-	-	JJ
cord-015021-pol2qm74	7106	8	feeding	feed	VBG
cord-015021-pol2qm74	7106	9	from	from	IN
cord-015021-pol2qm74	7106	10	0	0	CD
cord-015021-pol2qm74	7106	11	to	to	TO
cord-015021-pol2qm74	7106	12	8	8	CD
cord-015021-pol2qm74	7106	13	days	day	NNS
cord-015021-pol2qm74	7106	14	prior	prior	RB
cord-015021-pol2qm74	7106	15	to	to	IN
cord-015021-pol2qm74	7106	16	infection	infection	NN
cord-015021-pol2qm74	7106	17	did	do	VBD
cord-015021-pol2qm74	7106	18	not	not	RB
cord-015021-pol2qm74	7106	19	affect	affect	VB
cord-015021-pol2qm74	7106	20	these	these	DT
cord-015021-pol2qm74	7106	21	results	result	NNS
cord-015021-pol2qm74	7106	22	.	.	.
cord-015021-pol2qm74	7107	1	These	these	DT
cord-015021-pol2qm74	7107	2	data	datum	NNS
cord-015021-pol2qm74	7107	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	7107	4	that	that	IN
cord-015021-pol2qm74	7107	5	,	,	,
cord-015021-pol2qm74	7107	6	contrary	contrary	JJ
cord-015021-pol2qm74	7107	7	to	to	IN
cord-015021-pol2qm74	7107	8	previous	previous	JJ
cord-015021-pol2qm74	7107	9	reports	report	NNS
cord-015021-pol2qm74	7107	10	,	,	,
cord-015021-pol2qm74	7107	11	the	the	DT
cord-015021-pol2qm74	7107	12	use	use	NN
cord-015021-pol2qm74	7107	13	of	of	IN
cord-015021-pol2qm74	7107	14	specialized	specialized	JJ
cord-015021-pol2qm74	7107	15	nutrients	nutrient	NNS
cord-015021-pol2qm74	7107	16	did	do	VBD
cord-015021-pol2qm74	7107	17	not	not	RB
cord-015021-pol2qm74	7107	18	improve	improve	VB
cord-015021-pol2qm74	7107	19	resistance	resistance	NN
cord-015021-pol2qm74	7107	20	to	to	IN
cord-015021-pol2qm74	7107	21	disease	disease	NN
cord-015021-pol2qm74	7107	22	in	in	IN
cord-015021-pol2qm74	7107	23	mice	mouse	NNS
cord-015021-pol2qm74	7107	24	challenged	challenge	VBN
cord-015021-pol2qm74	7107	25	with	with	IN
cord-015021-pol2qm74	7107	26	L.	L.	NNP
cord-015021-pol2qm74	7107	27	monocytogenese	monocytogenese	NN
cord-015021-pol2qm74	7107	28	,	,	,
cord-015021-pol2qm74	7107	29	Influenza	Influenza	NNP
cord-015021-pol2qm74	7107	30	A	A	NNP
cord-015021-pol2qm74	7107	31	or	or	CC
cord-015021-pol2qm74	7107	32	C.	C.	NNP
cord-015021-pol2qm74	7107	33	albicans	albican	NNS
cord-015021-pol2qm74	7107	34	as	as	IN
cord-015021-pol2qm74	7107	35	compared	compare	VBN
cord-015021-pol2qm74	7107	36	with	with	IN
cord-015021-pol2qm74	7107	37	mice	mouse	NNS
cord-015021-pol2qm74	7107	38	fed	feed	VBD
cord-015021-pol2qm74	7107	39	Osmolite	Osmolite	NNP
cord-015021-pol2qm74	7107	40	HN	HN	NNP
cord-015021-pol2qm74	7107	41	.	.	.
cord-015021-pol2qm74	7108	1	Animals	animal	NNS
cord-015021-pol2qm74	7108	2	fed	feed	VBD
cord-015021-pol2qm74	7109	1	standard	standard	NNP
cord-015021-pol2qm74	7109	2	chow	chow	NNP
cord-015021-pol2qm74	7109	3	tended	tend	VBD
cord-015021-pol2qm74	7109	4	to	to	TO
cord-015021-pol2qm74	7109	5	be	be	VB
cord-015021-pol2qm74	7109	6	more	more	RBR
cord-015021-pol2qm74	7109	7	resistant	resistant	JJ
cord-015021-pol2qm74	7109	8	to	to	IN
cord-015021-pol2qm74	7109	9	infectious	infectious	JJ
cord-015021-pol2qm74	7109	10	disease	disease	NN
cord-015021-pol2qm74	7109	11	than	than	IN
cord-015021-pol2qm74	7109	12	those	those	DT
cord-015021-pol2qm74	7109	13	fed	feed	VBD
cord-015021-pol2qm74	7109	14	the	the	DT
cord-015021-pol2qm74	7109	15	liquid	liquid	JJ
cord-015021-pol2qm74	7109	16	formulas	formula	NNS
cord-015021-pol2qm74	7109	17	perhaps	perhaps	RB
cord-015021-pol2qm74	7109	18	due	due	IN
cord-015021-pol2qm74	7109	19	to	to	IN
cord-015021-pol2qm74	7109	20	the	the	DT
cord-015021-pol2qm74	7109	21	form	form	NN
cord-015021-pol2qm74	7109	22	of	of	IN
cord-015021-pol2qm74	7109	23	diet	diet	NN
cord-015021-pol2qm74	7109	24	or	or	CC
cord-015021-pol2qm74	7109	25	complexity	complexity	NN
cord-015021-pol2qm74	7109	26	of	of	IN
cord-015021-pol2qm74	7109	27	ingredients	ingredient	NNS
cord-015021-pol2qm74	7109	28	.	.	.
cord-015021-pol2qm74	7110	1	The	the	DT
cord-015021-pol2qm74	7110	2	results	result	NNS
cord-015021-pol2qm74	7110	3	indicate	indicate	VBP
cord-015021-pol2qm74	7110	4	that	that	IN
cord-015021-pol2qm74	7110	5	these	these	DT
cord-015021-pol2qm74	7110	6	animal	animal	NN
cord-015021-pol2qm74	7110	7	models	model	NNS
cord-015021-pol2qm74	7110	8	of	of	IN
cord-015021-pol2qm74	7110	9	infectious	infectious	JJ
cord-015021-pol2qm74	7110	10	challenge	challenge	NN
cord-015021-pol2qm74	7110	11	may	may	MD
cord-015021-pol2qm74	7110	12	be	be	VB
cord-015021-pol2qm74	7110	13	of	of	IN
cord-015021-pol2qm74	7110	14	limited	limited	JJ
cord-015021-pol2qm74	7110	15	use	use	NN
cord-015021-pol2qm74	7110	16	to	to	TO
cord-015021-pol2qm74	7110	17	distinguish	distinguish	VB
cord-015021-pol2qm74	7110	18	effects	effect	NNS
cord-015021-pol2qm74	7110	19	of	of	IN
cord-015021-pol2qm74	7110	20	modified	modify	VBN
cord-015021-pol2qm74	7110	21	nutrient	nutrient	NN
cord-015021-pol2qm74	7110	22	composition	composition	NN
cord-015021-pol2qm74	7110	23	of	of	IN
cord-015021-pol2qm74	7110	24	enteral	enteral	JJ
cord-015021-pol2qm74	7110	25	formulas	formula	NNS
cord-015021-pol2qm74	7110	26	.	.	.
cord-015021-pol2qm74	7111	1	Laboratories	laboratory	NNS
cord-015021-pol2qm74	7112	1	The	the	DT
cord-015021-pol2qm74	7112	2	beneficial	beneficial	JJ
cord-015021-pol2qm74	7112	3	effects	effect	NNS
cord-015021-pol2qm74	7112	4	of	of	IN
cord-015021-pol2qm74	7112	5	sesame	sesame	NN
cord-015021-pol2qm74	7112	6	oil	oil	NN
cord-015021-pol2qm74	7112	7	(	(	-LRB-
cord-015021-pol2qm74	7112	8	SES	SES	NNP
cord-015021-pol2qm74	7112	9	)	)	-RRB-
cord-015021-pol2qm74	7112	10	have	have	VBP
cord-015021-pol2qm74	7112	11	been	be	VBN
cord-015021-pol2qm74	7112	12	attributed	attribute	VBN
cord-015021-pol2qm74	7112	13	to	to	IN
cord-015021-pol2qm74	7112	14	the	the	DT
cord-015021-pol2qm74	7112	15	presence	presence	NN
cord-015021-pol2qm74	7112	16	ofsesamin	ofsesamin	NN
cord-015021-pol2qm74	7112	17	,	,	,
cord-015021-pol2qm74	7112	18	a	a	DT
cord-015021-pol2qm74	7112	19	non	non	JJ
cord-015021-pol2qm74	7112	20	-	-	JJ
cord-015021-pol2qm74	7112	21	fat	fat	JJ
cord-015021-pol2qm74	7112	22	constituent	constituent	NN
cord-015021-pol2qm74	7112	23	which	which	WDT
cord-015021-pol2qm74	7112	24	is	be	VBZ
cord-015021-pol2qm74	7112	25	claimed	claim	VBN
cord-015021-pol2qm74	7112	26	to	to	TO
cord-015021-pol2qm74	7112	27	iultibit	iultibit	VB
cord-015021-pol2qm74	7112	28	A-5	A-5	NNP
cord-015021-pol2qm74	7112	29	desaturase	desaturase	NN
cord-015021-pol2qm74	7112	30	activity	activity	NN
cord-015021-pol2qm74	7112	31	.	.	.
cord-015021-pol2qm74	7113	1	We	-PRON-	PRP
cord-015021-pol2qm74	7113	2	investigated	investigate	VBD
cord-015021-pol2qm74	7113	3	the	the	DT
cord-015021-pol2qm74	7113	4	effects	effect	NNS
cord-015021-pol2qm74	7113	5	of	of	IN
cord-015021-pol2qm74	7113	6	ad	ad	FW
cord-015021-pol2qm74	7113	7	libidum	libidum	FW
cord-015021-pol2qm74	7113	8	feeding	feeding	NN
cord-015021-pol2qm74	7113	9	of	of	IN
cord-015021-pol2qm74	7113	10	SES	SES	NNP
cord-015021-pol2qm74	7113	11	enriched	enrich	VBN
cord-015021-pol2qm74	7113	12	diet	diet	NN
cord-015021-pol2qm74	7113	13	on	on	IN
cord-015021-pol2qm74	7113	14	fatty	fatty	JJ
cord-015021-pol2qm74	7113	15	acid	acid	NN
cord-015021-pol2qm74	7113	16	composition	composition	NN
cord-015021-pol2qm74	7113	17	of	of	IN
cord-015021-pol2qm74	7113	18	phospholipids	phospholipid	NNS
cord-015021-pol2qm74	7113	19	from	from	IN
cord-015021-pol2qm74	7113	20	plasma	plasma	NN
cord-015021-pol2qm74	7113	21	,	,	,
cord-015021-pol2qm74	7113	22	liver	liver	NN
cord-015021-pol2qm74	7113	23	,	,	,
cord-015021-pol2qm74	7113	24	on	on	IN
cord-015021-pol2qm74	7113	25	eicosanoid	eicosanoid	JJ
cord-015021-pol2qm74	7113	26	production	production	NN
cord-015021-pol2qm74	7113	27	,	,	,
cord-015021-pol2qm74	7113	28	and	and	CC
cord-015021-pol2qm74	7113	29	on	on	IN
cord-015021-pol2qm74	7113	30	the	the	DT
cord-015021-pol2qm74	7113	31	protective	protective	JJ
cord-015021-pol2qm74	7113	32	effects	effect	NNS
cord-015021-pol2qm74	7113	33	in	in	IN
cord-015021-pol2qm74	7113	34	mice	mouse	NNS
cord-015021-pol2qm74	7113	35	after	after	IN
cord-015021-pol2qm74	7113	36	cecal	cecal	JJ
cord-015021-pol2qm74	7113	37	ligation	ligation	NN
cord-015021-pol2qm74	7113	38	and	and	CC
cord-015021-pol2qm74	7113	39	puncture	puncture	NN
cord-015021-pol2qm74	7113	40	(	(	-LRB-
cord-015021-pol2qm74	7113	41	CLP	CLP	NNP
cord-015021-pol2qm74	7113	42	)	)	-RRB-
cord-015021-pol2qm74	7113	43	and	and	CC
cord-015021-pol2qm74	7113	44	compared	compare	VBN
cord-015021-pol2qm74	7113	45	with	with	IN
cord-015021-pol2qm74	7113	46	safflower	safflower	NN
cord-015021-pol2qm74	7113	47	oil	oil	NN
cord-015021-pol2qm74	7113	48	(	(	-LRB-
cord-015021-pol2qm74	7113	49	SO	so	RB
cord-015021-pol2qm74	7113	50	)	)	-RRB-
cord-015021-pol2qm74	7113	51	diets	diet	NNS
cord-015021-pol2qm74	7113	52	.	.	.
cord-015021-pol2qm74	7114	1	Olive	olive	NN
cord-015021-pol2qm74	7114	2	and	and	CC
cord-015021-pol2qm74	7114	3	palm	palm	NNP
cord-015021-pol2qm74	7114	4	otis	otis	NNP
cord-015021-pol2qm74	7114	5	were	be	VBD
cord-015021-pol2qm74	7114	6	added	add	VBN
cord-015021-pol2qm74	7114	7	as	as	IN
cord-015021-pol2qm74	7114	8	filler	filler	NN
cord-015021-pol2qm74	7114	9	fats	fat	NNS
cord-015021-pol2qm74	7114	10	to	to	IN
cord-015021-pol2qm74	7114	11	the	the	DT
cord-015021-pol2qm74	7114	12	SO	so	JJ
cord-015021-pol2qm74	7114	13	diet	diet	NN
cord-015021-pol2qm74	7114	14	to	to	TO
cord-015021-pol2qm74	7114	15	maintain	maintain	VB
cord-015021-pol2qm74	7114	16	the	the	DT
cord-015021-pol2qm74	7114	17	ratios	ratio	NNS
cord-015021-pol2qm74	7114	18	of	of	IN
cord-015021-pol2qm74	7114	19	saturated	saturated	JJ
cord-015021-pol2qm74	7114	20	,	,	,
cord-015021-pol2qm74	7114	21	and	and	CC
cord-015021-pol2qm74	7114	22	unsaturated	unsaturated	JJ
cord-015021-pol2qm74	7114	23	fatty	fatty	JJ
cord-015021-pol2qm74	7114	24	acids	acid	NNS
cord-015021-pol2qm74	7114	25	similar	similar	JJ
cord-015021-pol2qm74	7114	26	to	to	IN
cord-015021-pol2qm74	7114	27	SES	SES	NNP
cord-015021-pol2qm74	7114	28	diet	diet	NN
cord-015021-pol2qm74	7114	29	.	.	.
cord-015021-pol2qm74	7115	1	Thus	thus	RB
cord-015021-pol2qm74	7115	2	,	,	,
cord-015021-pol2qm74	7115	3	while	while	IN
cord-015021-pol2qm74	7115	4	the	the	DT
cord-015021-pol2qm74	7115	5	total	total	JJ
cord-015021-pol2qm74	7115	6	fat	fat	NN
cord-015021-pol2qm74	7115	7	remained	remain	VBD
cord-015021-pol2qm74	7115	8	at	at	IN
cord-015021-pol2qm74	7115	9	15wt%	15wt%	CD
cord-015021-pol2qm74	7115	10	,	,	,
cord-015021-pol2qm74	7115	11	the	the	DT
cord-015021-pol2qm74	7115	12	only	only	JJ
cord-015021-pol2qm74	7115	13	difference	difference	NN
cord-015021-pol2qm74	7115	14	between	between	IN
cord-015021-pol2qm74	7115	15	the	the	DT
cord-015021-pol2qm74	7115	16	two	two	CD
cord-015021-pol2qm74	7115	17	diets	diet	NNS
cord-015021-pol2qm74	7115	18	is	be	VBZ
cord-015021-pol2qm74	7115	19	the	the	DT
cord-015021-pol2qm74	7115	20	presence	presence	NN
cord-015021-pol2qm74	7115	21	ofsesamin	ofsesamin	NN
cord-015021-pol2qm74	7115	22	in	in	IN
cord-015021-pol2qm74	7115	23	SES	SES	NNP
cord-015021-pol2qm74	7115	24	diet	diet	NN
cord-015021-pol2qm74	7115	25	.	.	.
cord-015021-pol2qm74	7116	1	The	the	DT
cord-015021-pol2qm74	7116	2	animals	animal	NNS
cord-015021-pol2qm74	7116	3	were	be	VBD
cord-015021-pol2qm74	7116	4	fed	feed	VBN
cord-015021-pol2qm74	7116	5	for	for	IN
cord-015021-pol2qm74	7116	6	3	3	CD
cord-015021-pol2qm74	7116	7	weeks	week	NNS
cord-015021-pol2qm74	7116	8	.	.	.
cord-015021-pol2qm74	7117	1	The	the	DT
cord-015021-pol2qm74	7117	2	incorporation	incorporation	NN
cord-015021-pol2qm74	7117	3	of	of	IN
cord-015021-pol2qm74	7117	4	dihomo	dihomo	NNP
cord-015021-pol2qm74	7117	5	-	-	HYPH
cord-015021-pol2qm74	7117	6	y	y	NNP
cord-015021-pol2qm74	7117	7	-	-	HYPH
cord-015021-pol2qm74	7117	8	linolealc	linolealc	NN
cord-015021-pol2qm74	7117	9	acid	acid	NN
cord-015021-pol2qm74	7117	10	(	(	-LRB-
cord-015021-pol2qm74	7117	11	DGLA	DGLA	NNP
cord-015021-pol2qm74	7117	12	:	:	:
cord-015021-pol2qm74	7117	13	20:3	20:3	CD
cord-015021-pol2qm74	7117	14	o)-6	o)-6	NN
cord-015021-pol2qm74	7117	15	)	)	-RRB-
cord-015021-pol2qm74	7117	16	in	in	IN
cord-015021-pol2qm74	7117	17	the	the	DT
cord-015021-pol2qm74	7117	18	phospholipids	phospholipid	NNS
cord-015021-pol2qm74	7117	19	from	from	IN
cord-015021-pol2qm74	7117	20	plasma	plasma	NN
cord-015021-pol2qm74	7117	21	and	and	CC
cord-015021-pol2qm74	7117	22	from	from	IN
cord-015021-pol2qm74	7117	23	the	the	DT
cord-015021-pol2qm74	7117	24	liver	liver	NN
cord-015021-pol2qm74	7117	25	for	for	IN
cord-015021-pol2qm74	7117	26	the	the	DT
cord-015021-pol2qm74	7117	27	group	group	NN
cord-015021-pol2qm74	7117	28	of	of	IN
cord-015021-pol2qm74	7117	29	mice	mouse	NNS
cord-015021-pol2qm74	7117	30	fed	feed	VBN
cord-015021-pol2qm74	7117	31	SO	so	RB
cord-015021-pol2qm74	7117	32	diet	diet	NN
cord-015021-pol2qm74	7117	33	ranged	range	VBD
cord-015021-pol2qm74	7117	34	between	between	IN
cord-015021-pol2qm74	7117	35	1	1	CD
cord-015021-pol2qm74	7117	36	-	-	SYM
cord-015021-pol2qm74	7117	37	3	3	CD
cord-015021-pol2qm74	7117	38	%	%	NN
cord-015021-pol2qm74	7117	39	compared	compare	VBN
cord-015021-pol2qm74	7117	40	to	to	IN
cord-015021-pol2qm74	7117	41	the	the	DT
cord-015021-pol2qm74	7117	42	undetectable	undetectable	JJ
cord-015021-pol2qm74	7117	43	levels	level	NNS
cord-015021-pol2qm74	7117	44	for	for	IN
cord-015021-pol2qm74	7117	45	those	those	DT
cord-015021-pol2qm74	7117	46	fed	feed	VBN
cord-015021-pol2qm74	7117	47	SO	SO	NNP
cord-015021-pol2qm74	7117	48	diet	diet	NN
cord-015021-pol2qm74	7117	49	.	.	.
cord-015021-pol2qm74	7118	1	There	there	EX
cord-015021-pol2qm74	7118	2	were	be	VBD
cord-015021-pol2qm74	7118	3	no	no	DT
cord-015021-pol2qm74	7118	4	significant	significant	JJ
cord-015021-pol2qm74	7118	5	differences	difference	NNS
cord-015021-pol2qm74	7118	6	in	in	IN
cord-015021-pol2qm74	7118	7	the	the	DT
cord-015021-pol2qm74	7118	8	incorporation	incorporation	NN
cord-015021-pol2qm74	7118	9	of	of	IN
cord-015021-pol2qm74	7118	10	other	other	JJ
cord-015021-pol2qm74	7118	11	fatty	fatty	JJ
cord-015021-pol2qm74	7118	12	acids	acid	NNS
cord-015021-pol2qm74	7118	13	either	either	CC
cord-015021-pol2qm74	7118	14	in	in	IN
cord-015021-pol2qm74	7118	15	plasma	plasma	NN
cord-015021-pol2qm74	7118	16	or	or	CC
cord-015021-pol2qm74	7118	17	in	in	IN
cord-015021-pol2qm74	7118	18	the	the	DT
cord-015021-pol2qm74	7118	19	cell	cell	NN
cord-015021-pol2qm74	7118	20	membranes	membrane	NNS
cord-015021-pol2qm74	7118	21	between	between	IN
cord-015021-pol2qm74	7118	22	the	the	DT
cord-015021-pol2qm74	7118	23	two	two	CD
cord-015021-pol2qm74	7118	24	groups	group	NNS
cord-015021-pol2qm74	7118	25	.	.	.
cord-015021-pol2qm74	7119	1	Following	follow	VBG
cord-015021-pol2qm74	7119	2	an	an	DT
cord-015021-pol2qm74	7119	3	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	7119	4	administration	administration	NN
cord-015021-pol2qm74	7119	5	ofLPS	oflp	NNS
cord-015021-pol2qm74	7119	6	(	(	-LRB-
cord-015021-pol2qm74	7119	7	10p.g	10p.g	CD
cord-015021-pol2qm74	7119	8	/	/	SYM
cord-015021-pol2qm74	7119	9	kg	kg	NN
cord-015021-pol2qm74	7119	10	body	body	NN
cord-015021-pol2qm74	7119	11	wt	wt	NNP
cord-015021-pol2qm74	7119	12	)	)	-RRB-
cord-015021-pol2qm74	7119	13	,	,	,
cord-015021-pol2qm74	7119	14	the	the	DT
cord-015021-pol2qm74	7119	15	plasma	plasma	NN
cord-015021-pol2qm74	7119	16	levels	level	NNS
cord-015021-pol2qm74	7119	17	of	of	IN
cord-015021-pol2qm74	7119	18	both	both	CC
cord-015021-pol2qm74	7119	19	PGE2	PGE2	NNP
cord-015021-pol2qm74	7119	20	,	,	,
cord-015021-pol2qm74	7119	21	and	and	CC
cord-015021-pol2qm74	7119	22	TxB2	TxB2	NNS
cord-015021-pol2qm74	7119	23	,	,	,
cord-015021-pol2qm74	7119	24	were	be	VBD
cord-015021-pol2qm74	7119	25	significantly	significantly	RB
cord-015021-pol2qm74	7119	26	decreased	decrease	VBN
cord-015021-pol2qm74	7119	27	(	(	-LRB-
cord-015021-pol2qm74	7119	28	P<0.02	p<0.02	JJ
cord-015021-pol2qm74	7119	29	)	)	-RRB-
cord-015021-pol2qm74	7119	30	by	by	IN
cord-015021-pol2qm74	7119	31	nearly	nearly	RB
cord-015021-pol2qm74	7119	32	50	50	CD
cord-015021-pol2qm74	7119	33	%	%	NN
cord-015021-pol2qm74	7119	34	for	for	IN
cord-015021-pol2qm74	7119	35	the	the	DT
cord-015021-pol2qm74	7119	36	group	group	NN
cord-015021-pol2qm74	7119	37	of	of	IN
cord-015021-pol2qm74	7119	38	animals	animal	NNS
cord-015021-pol2qm74	7119	39	maintained	maintain	VBN
cord-015021-pol2qm74	7119	40	on	on	IN
cord-015021-pol2qm74	7119	41	SES	SES	NNP
cord-015021-pol2qm74	7119	42	diet	diet	NN
cord-015021-pol2qm74	7119	43	compared	compare	VBN
cord-015021-pol2qm74	7119	44	to	to	IN
cord-015021-pol2qm74	7119	45	those	those	DT
cord-015021-pol2qm74	7119	46	maintained	maintain	VBN
cord-015021-pol2qm74	7119	47	on	on	IN
cord-015021-pol2qm74	7119	48	SO	so	RB
cord-015021-pol2qm74	7119	49	diet	diet	NN
cord-015021-pol2qm74	7119	50	.	.	.
cord-015021-pol2qm74	7120	1	These	these	DT
cord-015021-pol2qm74	7120	2	findings	finding	NNS
cord-015021-pol2qm74	7120	3	suggest	suggest	VBP
cord-015021-pol2qm74	7120	4	that	that	IN
cord-015021-pol2qm74	7120	5	sesamin	sesamin	NNP
cord-015021-pol2qm74	7120	6	inhibited	inhibit	VBD
cord-015021-pol2qm74	7120	7	the	the	DT
cord-015021-pol2qm74	7120	8	release	release	NN
cord-015021-pol2qm74	7120	9	of	of	IN
cord-015021-pol2qm74	7120	10	arachidonic	arachidonic	JJ
cord-015021-pol2qm74	7120	11	acid	acid	NN
cord-015021-pol2qm74	7120	12	(	(	-LRB-
cord-015021-pol2qm74	7120	13	AA	AA	NNP
cord-015021-pol2qm74	7120	14	)	)	-RRB-
cord-015021-pol2qm74	7120	15	which	which	WDT
cord-015021-pol2qm74	7120	16	upon	upon	IN
cord-015021-pol2qm74	7120	17	accumulation	accumulation	NN
cord-015021-pol2qm74	7120	18	is	be	VBZ
cord-015021-pol2qm74	7120	19	retroconverted	retroconverte	VBN
cord-015021-pol2qm74	7120	20	to	to	IN
cord-015021-pol2qm74	7120	21	DGLA	DGLA	NNP
cord-015021-pol2qm74	7120	22	which	which	WDT
cord-015021-pol2qm74	7120	23	could	could	MD
cord-015021-pol2qm74	7120	24	reflect	reflect	VB
cord-015021-pol2qm74	7120	25	a	a	DT
cord-015021-pol2qm74	7120	26	modest	modest	JJ
cord-015021-pol2qm74	7120	27	increase	increase	NN
cord-015021-pol2qm74	7120	28	in	in	IN
cord-015021-pol2qm74	7120	29	the	the	DT
cord-015021-pol2qm74	7120	30	content	content	NN
cord-015021-pol2qm74	7120	31	of	of	IN
cord-015021-pol2qm74	7120	32	DGLA	DGLA	NNP
cord-015021-pol2qm74	7120	33	.	.	.
cord-015021-pol2qm74	7121	1	Failure	failure	NN
cord-015021-pol2qm74	7121	2	to	to	TO
cord-015021-pol2qm74	7121	3	decrease	decrease	VB
cord-015021-pol2qm74	7121	4	the	the	DT
cord-015021-pol2qm74	7121	5	formation	formation	NN
cord-015021-pol2qm74	7121	6	of	of	IN
cord-015021-pol2qm74	7121	7	AA	AA	NNP
cord-015021-pol2qm74	7121	8	could	could	MD
cord-015021-pol2qm74	7121	9	mean	mean	VB
cord-015021-pol2qm74	7121	10	that	that	IN
cord-015021-pol2qm74	7121	11	the	the	DT
cord-015021-pol2qm74	7121	12	effects	effect	NNS
cord-015021-pol2qm74	7121	13	of	of	IN
cord-015021-pol2qm74	7121	14	sesamin	sesamin	NN
cord-015021-pol2qm74	7121	15	on	on	IN
cord-015021-pol2qm74	7121	16	chain	chain	NN
cord-015021-pol2qm74	7121	17	elongation	elongation	NN
cord-015021-pol2qm74	7121	18	process	process	NN
cord-015021-pol2qm74	7121	19	may	may	MD
cord-015021-pol2qm74	7121	20	be	be	VB
cord-015021-pol2qm74	7121	21	after	after	IN
cord-015021-pol2qm74	7121	22	AA	AA	NNP
cord-015021-pol2qm74	7121	23	is	be	VBZ
cord-015021-pol2qm74	7121	24	formed	form	VBN
cord-015021-pol2qm74	7121	25	,	,	,
cord-015021-pol2qm74	7121	26	and	and	CC
cord-015021-pol2qm74	7121	27	that	that	IN
cord-015021-pol2qm74	7121	28	sesamin	sesamin	NNS
cord-015021-pol2qm74	7121	29	may	may	MD
cord-015021-pol2qm74	7121	30	not	not	RB
cord-015021-pol2qm74	7121	31	inhibit	inhibit	VB
cord-015021-pol2qm74	7121	32	A-5	A-5	NNP
cord-015021-pol2qm74	7121	33	desaturase	desaturase	NN
cord-015021-pol2qm74	7121	34	activity	activity	NN
cord-015021-pol2qm74	7121	35	.	.	.
cord-015021-pol2qm74	7122	1	On	on	IN
cord-015021-pol2qm74	7122	2	the	the	DT
cord-015021-pol2qm74	7122	3	other	other	JJ
cord-015021-pol2qm74	7122	4	hand	hand	NN
cord-015021-pol2qm74	7122	5	,	,	,
cord-015021-pol2qm74	7122	6	our	-PRON-	PRP$
cord-015021-pol2qm74	7122	7	data	datum	NNS
cord-015021-pol2qm74	7122	8	suggest	suggest	VBP
cord-015021-pol2qm74	7122	9	that	that	IN
cord-015021-pol2qm74	7122	10	sesamin	sesamin	NN
cord-015021-pol2qm74	7122	11	present	present	JJ
cord-015021-pol2qm74	7122	12	in	in	IN
cord-015021-pol2qm74	7122	13	sesame	sesame	NN
cord-015021-pol2qm74	7122	14	oil	oil	NN
cord-015021-pol2qm74	7122	15	inhibited	inhibit	VBD
cord-015021-pol2qm74	7122	16	the	the	DT
cord-015021-pol2qm74	7122	17	activity	activity	NN
cord-015021-pol2qm74	7122	18	of	of	IN
cord-015021-pol2qm74	7122	19	cyclooxygenase	cyclooxygenase	NN
cord-015021-pol2qm74	7122	20	which	which	WDT
cord-015021-pol2qm74	7122	21	converts	convert	VBZ
cord-015021-pol2qm74	7122	22	AA	AA	NNP
cord-015021-pol2qm74	7122	23	to	to	IN
cord-015021-pol2qm74	7122	24	its	-PRON-	PRP$
cord-015021-pol2qm74	7122	25	metabolites	metabolite	NNS
cord-015021-pol2qm74	7122	26	)	)	-RRB-
cord-015021-pol2qm74	7122	27	,	,	,
cord-015021-pol2qm74	7122	28	or	or	CC
cord-015021-pol2qm74	7122	29	alternatively	alternatively	RB
cord-015021-pol2qm74	7122	30	could	could	MD
cord-015021-pol2qm74	7122	31	block	block	VB
cord-015021-pol2qm74	7122	32	the	the	DT
cord-015021-pol2qm74	7122	33	activity	activity	NN
cord-015021-pol2qm74	7122	34	of	of	IN
cord-015021-pol2qm74	7123	1	phosphalipase	phosphalipase	NNP
cord-015021-pol2qm74	7123	2	A	a	DT
cord-015021-pol2qm74	7123	3	2	2	CD
cord-015021-pol2qm74	7124	1	(	(	-LRB-
cord-015021-pol2qm74	7124	2	PLA2	PLA2	NNP
cord-015021-pol2qm74	7124	3	)	)	-RRB-
cord-015021-pol2qm74	7124	4	(	(	-LRB-
cord-015021-pol2qm74	7124	5	which	which	WDT
cord-015021-pol2qm74	7124	6	releases	release	VBZ
cord-015021-pol2qm74	7124	7	AA	AA	NNP
cord-015021-pol2qm74	7124	8	from	from	IN
cord-015021-pol2qm74	7124	9	membrane	membrane	NN
cord-015021-pol2qm74	7124	10	phospholipids	phospholipid	NNS
cord-015021-pol2qm74	7124	11	)	)	-RRB-
cord-015021-pol2qm74	7124	12	as	as	IN
cord-015021-pol2qm74	7124	13	is	be	VBZ
cord-015021-pol2qm74	7124	14	evident	evident	JJ
cord-015021-pol2qm74	7124	15	from	from	IN
cord-015021-pol2qm74	7124	16	a	a	DT
cord-015021-pol2qm74	7124	17	marked	marked	JJ
cord-015021-pol2qm74	7124	18	decrease	decrease	NN
cord-015021-pol2qm74	7124	19	in	in	IN
cord-015021-pol2qm74	7124	20	eicosanoid	eicosanoid	JJ
cord-015021-pol2qm74	7124	21	production	production	NN
cord-015021-pol2qm74	7124	22	.	.	.
cord-015021-pol2qm74	7125	1	The	the	DT
cord-015021-pol2qm74	7125	2	percentage	percentage	NN
cord-015021-pol2qm74	7125	3	of	of	IN
cord-015021-pol2qm74	7125	4	animals	animal	NNS
cord-015021-pol2qm74	7125	5	surviving	survive	VBG
cord-015021-pol2qm74	7125	6	after	after	IN
cord-015021-pol2qm74	7125	7	cecal	cecal	JJ
cord-015021-pol2qm74	7125	8	ligation	ligation	NN
cord-015021-pol2qm74	7125	9	and	and	CC
cord-015021-pol2qm74	7125	10	puncture	puncture	NN
cord-015021-pol2qm74	7125	11	in	in	IN
cord-015021-pol2qm74	7125	12	rite	rite	JJ
cord-015021-pol2qm74	7125	13	group	group	NN
cord-015021-pol2qm74	7125	14	of	of	IN
cord-015021-pol2qm74	7125	15	mice	mouse	NNS
cord-015021-pol2qm74	7125	16	fed	fed	NNP
cord-015021-pol2qm74	7125	17	SES	SES	NNP
cord-015021-pol2qm74	7125	18	diet	diet	NN
cord-015021-pol2qm74	7125	19	was	be	VBD
cord-015021-pol2qm74	7125	20	65	65	CD
cord-015021-pol2qm74	7125	21	%	%	NN
cord-015021-pol2qm74	7125	22	(	(	-LRB-
cord-015021-pol2qm74	7125	23	13/20	13/20	CD
cord-015021-pol2qm74	7125	24	)	)	-RRB-
cord-015021-pol2qm74	7125	25	which	which	WDT
cord-015021-pol2qm74	7125	26	was	be	VBD
cord-015021-pol2qm74	7125	27	markedly	markedly	RB
cord-015021-pol2qm74	7125	28	higher	high	JJR
cord-015021-pol2qm74	7125	29	(	(	-LRB-
cord-015021-pol2qm74	7125	30	p<0.01	p<0.01	NN
cord-015021-pol2qm74	7125	31	)	)	-RRB-
cord-015021-pol2qm74	7125	32	compared	compare	VBN
cord-015021-pol2qm74	7125	33	to	to	IN
cord-015021-pol2qm74	7125	34	only	only	RB
cord-015021-pol2qm74	7125	35	20	20	CD
cord-015021-pol2qm74	7125	36	%	%	NN
cord-015021-pol2qm74	7125	37	(	(	-LRB-
cord-015021-pol2qm74	7125	38	4/20	4/20	CD
cord-015021-pol2qm74	7125	39	)	)	-RRB-
cord-015021-pol2qm74	7125	40	for	for	IN
cord-015021-pol2qm74	7125	41	the	the	DT
cord-015021-pol2qm74	7125	42	SO	so	JJ
cord-015021-pol2qm74	7125	43	group	group	NN
cord-015021-pol2qm74	7125	44	.	.	.
cord-015021-pol2qm74	7126	1	Increase	increase	VB
cord-015021-pol2qm74	7126	2	in	in	IN
cord-015021-pol2qm74	7126	3	survival	survival	NN
cord-015021-pol2qm74	7126	4	in	in	IN
cord-015021-pol2qm74	7126	5	the	the	DT
cord-015021-pol2qm74	7126	6	group	group	NN
cord-015021-pol2qm74	7126	7	of	of	IN
cord-015021-pol2qm74	7126	8	mice	mouse	NNS
cord-015021-pol2qm74	7126	9	fed	fed	NNP
cord-015021-pol2qm74	7126	10	SES	SES	NNP
cord-015021-pol2qm74	7126	11	diet	diet	NN
cord-015021-pol2qm74	7126	12	was	be	VBD
cord-015021-pol2qm74	7126	13	associated	associate	VBN
cord-015021-pol2qm74	7126	14	with	with	IN
cord-015021-pol2qm74	7126	15	nearly	nearly	RB
cord-015021-pol2qm74	7126	16	50	50	CD
cord-015021-pol2qm74	7126	17	%	%	NN
cord-015021-pol2qm74	7126	18	reduction	reduction	NN
cord-015021-pol2qm74	7126	19	in	in	IN
cord-015021-pol2qm74	7126	20	the	the	DT
cord-015021-pol2qm74	7126	21	production	production	NN
cord-015021-pol2qm74	7126	22	of	of	IN
cord-015021-pol2qm74	7126	23	TNF	TNF	NNP
cord-015021-pol2qm74	7126	24	in	in	IN
cord-015021-pol2qm74	7126	25	response	response	NN
cord-015021-pol2qm74	7126	26	to	to	IN
cord-015021-pol2qm74	7126	27	LPS	LPS	NNP
cord-015021-pol2qm74	7126	28	i.p	i.p	NNP
cord-015021-pol2qm74	7126	29	.	.	NNP
cord-015021-pol2qm74	7126	30	challenge	challenge	NN
cord-015021-pol2qm74	7126	31	,	,	,
cord-015021-pol2qm74	7126	32	for	for	IN
cord-015021-pol2qm74	7126	33	SES	SES	NNP
cord-015021-pol2qm74	7126	34	group	group	NN
cord-015021-pol2qm74	7126	35	compared	compare	VBN
cord-015021-pol2qm74	7126	36	to	to	IN
cord-015021-pol2qm74	7126	37	SO	so	RB
cord-015021-pol2qm74	7126	38	fed	fed	JJ
cord-015021-pol2qm74	7126	39	animals	animal	NNS
cord-015021-pol2qm74	7126	40	.	.	.
cord-015021-pol2qm74	7127	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	7127	2	data	datum	NNS
cord-015021-pol2qm74	7127	3	suggest	suggest	VBP
cord-015021-pol2qm74	7127	4	that	that	IN
cord-015021-pol2qm74	7127	5	sesamin	sesamin	NNS
cord-015021-pol2qm74	7127	6	,	,	,
cord-015021-pol2qm74	7127	7	present	present	JJ
cord-015021-pol2qm74	7127	8	in	in	IN
cord-015021-pol2qm74	7127	9	sesame	sesame	NN
cord-015021-pol2qm74	7127	10	oil	oil	NN
cord-015021-pol2qm74	7127	11	,	,	,
cord-015021-pol2qm74	7127	12	decreased	decrease	VBD
cord-015021-pol2qm74	7127	13	the	the	DT
cord-015021-pol2qm74	7127	14	production	production	NN
cord-015021-pol2qm74	7127	15	TNF~	tnf~	RB
cord-015021-pol2qm74	7127	16	,	,	,
cord-015021-pol2qm74	7127	17	inhibited	inhibit	VBD
cord-015021-pol2qm74	7127	18	the	the	DT
cord-015021-pol2qm74	7127	19	activity	activity	NN
cord-015021-pol2qm74	7127	20	ofPLA	ofpla	IN
cord-015021-pol2qm74	7127	21	2	2	CD
cord-015021-pol2qm74	7127	22	and	and	CC
cord-015021-pol2qm74	7127	23	consequently	consequently	RB
cord-015021-pol2qm74	7127	24	offered	offer	VBD
cord-015021-pol2qm74	7127	25	a	a	DT
cord-015021-pol2qm74	7127	26	significant	significant	JJ
cord-015021-pol2qm74	7127	27	protection	protection	NN
cord-015021-pol2qm74	7127	28	against	against	IN
cord-015021-pol2qm74	7127	29	CLP	CLP	NNP
cord-015021-pol2qm74	7127	30	.	.	.
cord-015021-pol2qm74	7128	1	Thus	thus	RB
cord-015021-pol2qm74	7128	2	sesamin	sesamin	NNP
cord-015021-pol2qm74	7128	3	or	or	CC
cord-015021-pol2qm74	7128	4	sesame	sesame	NN
cord-015021-pol2qm74	7128	5	oil	oil	NN
cord-015021-pol2qm74	7128	6	appear	appear	VBP
cord-015021-pol2qm74	7128	7	to	to	TO
cord-015021-pol2qm74	7128	8	be	be	VB
cord-015021-pol2qm74	7128	9	novel	novel	JJ
cord-015021-pol2qm74	7128	10	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	7128	11	agents	agent	NNS
cord-015021-pol2qm74	7128	12	which	which	WDT
cord-015021-pol2qm74	7128	13	are	be	VBP
cord-015021-pol2qm74	7128	14	present	present	JJ
cord-015021-pol2qm74	7128	15	naturally	naturally	RB
cord-015021-pol2qm74	7128	16	in	in	IN
cord-015021-pol2qm74	7128	17	many	many	JJ
cord-015021-pol2qm74	7128	18	edible	edible	JJ
cord-015021-pol2qm74	7128	19	products	product	NNS
cord-015021-pol2qm74	7128	20	.	.	.
cord-015021-pol2qm74	7129	1	[	[	-LRB-
cord-015021-pol2qm74	7129	2	Dept	Dept	NNP
cord-015021-pol2qm74	7129	3	.	.	.
cord-015021-pol2qm74	7130	1	Surgery	surgery	NN
cord-015021-pol2qm74	7130	2	,	,	,
cord-015021-pol2qm74	7130	3	~E.	~E.	NNP
cord-015021-pol2qm74	7130	4	Deasoness	Deasoness	NNP
cord-015021-pol2qm74	7130	5	Hosp	Hosp	NNP
cord-015021-pol2qm74	7130	6	.	.	.
cord-015021-pol2qm74	7131	1	,	,	,
cord-015021-pol2qm74	7131	2	Harvard	Harvard	NNP
cord-015021-pol2qm74	7132	1	Medical	Medical	NNP
cord-015021-pol2qm74	7132	2	School	School	NNP
cord-015021-pol2qm74	7132	3	,	,	,
cord-015021-pol2qm74	7132	4	Boston	Boston	NNP
cord-015021-pol2qm74	7132	5	,	,	,
cord-015021-pol2qm74	7132	6	USA	USA	NNP
cord-015021-pol2qm74	7132	7	]	]	-RRB-
cord-015021-pol2qm74	7132	8	Stress	Stress	NNP
cord-015021-pol2qm74	7132	9	causes	cause	VBZ
cord-015021-pol2qm74	7132	10	alterations	alteration	NNS
cord-015021-pol2qm74	7132	11	in	in	IN
cord-015021-pol2qm74	7132	12	the	the	DT
cord-015021-pol2qm74	7132	13	homeostasis	homeostasis	NN
cord-015021-pol2qm74	7132	14	of	of	IN
cord-015021-pol2qm74	7132	15	an	an	DT
cord-015021-pol2qm74	7132	16	organism	organism	NN
cord-015021-pol2qm74	7132	17	with	with	IN
cord-015021-pol2qm74	7132	18	major	major	JJ
cord-015021-pol2qm74	7132	19	changes	change	NNS
cord-015021-pol2qm74	7132	20	in	in	IN
cord-015021-pol2qm74	7132	21	various	various	JJ
cord-015021-pol2qm74	7132	22	organs	organ	NNS
cord-015021-pol2qm74	7132	23	,	,	,
cord-015021-pol2qm74	7132	24	lifespans	lifespan	NNS
cord-015021-pol2qm74	7132	25	of	of	IN
cord-015021-pol2qm74	7132	26	cells	cell	NNS
cord-015021-pol2qm74	7132	27	,	,	,
cord-015021-pol2qm74	7132	28	protein	protein	NN
cord-015021-pol2qm74	7132	29	turnovers	turnover	NNS
cord-015021-pol2qm74	7132	30	,	,	,
cord-015021-pol2qm74	7132	31	metabolic	metabolic	JJ
cord-015021-pol2qm74	7132	32	pathways	pathway	NNS
cord-015021-pol2qm74	7132	33	of	of	IN
cord-015021-pol2qm74	7132	34	activation	activation	NN
cord-015021-pol2qm74	7132	35	or	or	CC
cord-015021-pol2qm74	7132	36	stimulation	stimulation	NN
cord-015021-pol2qm74	7132	37	,	,	,
cord-015021-pol2qm74	7132	38	energy	energy	NN
cord-015021-pol2qm74	7132	39	mobilization	mobilization	NN
cord-015021-pol2qm74	7132	40	,	,	,
cord-015021-pol2qm74	7132	41	etc	etc	FW
cord-015021-pol2qm74	7132	42	.	.	.
cord-015021-pol2qm74	7133	1	Punctual	punctual	JJ
cord-015021-pol2qm74	7133	2	changes	change	NNS
cord-015021-pol2qm74	7133	3	have	have	VBP
cord-015021-pol2qm74	7133	4	been	be	VBN
cord-015021-pol2qm74	7133	5	described	describe	VBN
cord-015021-pol2qm74	7133	6	in	in	IN
cord-015021-pol2qm74	7133	7	several	several	JJ
cord-015021-pol2qm74	7133	8	organs	organ	NNS
cord-015021-pol2qm74	7133	9	and	and	CC
cord-015021-pol2qm74	7133	10	various	various	JJ
cord-015021-pol2qm74	7133	11	cell	cell	NN
cord-015021-pol2qm74	7133	12	types	type	NNS
cord-015021-pol2qm74	7133	13	of	of	IN
cord-015021-pol2qm74	7133	14	the	the	DT
cord-015021-pol2qm74	7133	15	nervous	nervous	JJ
cord-015021-pol2qm74	7133	16	,	,	,
cord-015021-pol2qm74	7133	17	endocrine	endocrine	JJ
cord-015021-pol2qm74	7133	18	and	and	CC
cord-015021-pol2qm74	7133	19	immune	immune	JJ
cord-015021-pol2qm74	7133	20	systems	system	NNS
cord-015021-pol2qm74	7133	21	.	.	.
cord-015021-pol2qm74	7134	1	Many	many	JJ
cord-015021-pol2qm74	7134	2	stored	store	VBN
cord-015021-pol2qm74	7134	3	or	or	CC
cord-015021-pol2qm74	7134	4	newly	newly	RB
cord-015021-pol2qm74	7134	5	synthesized	synthesize	VBN
cord-015021-pol2qm74	7134	6	proteins	protein	NNS
cord-015021-pol2qm74	7134	7	are	be	VBP
cord-015021-pol2qm74	7134	8	released	release	VBN
cord-015021-pol2qm74	7134	9	to	to	IN
cord-015021-pol2qm74	7134	10	the	the	DT
cord-015021-pol2qm74	7134	11	bloodstream	bloodstream	NN
cord-015021-pol2qm74	7134	12	to	to	TO
cord-015021-pol2qm74	7134	13	be	be	VB
cord-015021-pol2qm74	7134	14	transported	transport	VBN
cord-015021-pol2qm74	7134	15	to	to	TO
cord-015021-pol2qm74	7134	16	target	target	VB
cord-015021-pol2qm74	7134	17	organs	organ	NNS
cord-015021-pol2qm74	7134	18	or	or	CC
cord-015021-pol2qm74	7134	19	to	to	TO
cord-015021-pol2qm74	7134	20	be	be	VB
cord-015021-pol2qm74	7134	21	disposed	dispose	VBN
cord-015021-pol2qm74	7134	22	of	of	IN
cord-015021-pol2qm74	7134	23	.	.	.
cord-015021-pol2qm74	7135	1	As	as	IN
cord-015021-pol2qm74	7135	2	stress	stress	NN
cord-015021-pol2qm74	7135	3	alters	alter	VBZ
cord-015021-pol2qm74	7135	4	protein	protein	NN
cord-015021-pol2qm74	7135	5	synthesis	synthesis	NN
cord-015021-pol2qm74	7135	6	and	and	CC
cord-015021-pol2qm74	7135	7	requirements	requirement	NNS
cord-015021-pol2qm74	7135	8	in	in	IN
cord-015021-pol2qm74	7135	9	the	the	DT
cord-015021-pol2qm74	7135	10	targets	target	NNS
cord-015021-pol2qm74	7135	11	,	,	,
cord-015021-pol2qm74	7135	12	the	the	DT
cord-015021-pol2qm74	7135	13	bloodstream	bloodstream	NN
cord-015021-pol2qm74	7135	14	is	be	VBZ
cord-015021-pol2qm74	7135	15	a	a	DT
cord-015021-pol2qm74	7135	16	useful	useful	JJ
cord-015021-pol2qm74	7135	17	system	system	NN
cord-015021-pol2qm74	7135	18	for	for	IN
cord-015021-pol2qm74	7135	19	monitoring	monitor	VBG
cord-015021-pol2qm74	7135	20	the	the	DT
cord-015021-pol2qm74	7135	21	relevant	relevant	JJ
cord-015021-pol2qm74	7135	22	changes	change	NNS
cord-015021-pol2qm74	7135	23	.	.	.
cord-015021-pol2qm74	7136	1	We	-PRON-	PRP
cord-015021-pol2qm74	7136	2	present	present	VBP
cord-015021-pol2qm74	7136	3	here	here	RB
cord-015021-pol2qm74	7136	4	the	the	DT
cord-015021-pol2qm74	7136	5	pattern	pattern	NN
cord-015021-pol2qm74	7136	6	of	of	IN
cord-015021-pol2qm74	7136	7	newly	newly	RB
cord-015021-pol2qm74	7136	8	synthesized	synthesize	VBN
cord-015021-pol2qm74	7136	9	or	or	CC
cord-015021-pol2qm74	7136	10	released	release	VBN
cord-015021-pol2qm74	7136	11	serum	serum	NN
cord-015021-pol2qm74	7136	12	proteins	protein	NNS
cord-015021-pol2qm74	7136	13	in	in	IN
cord-015021-pol2qm74	7136	14	C57BL/6	C57BL/6	NNP
cord-015021-pol2qm74	7136	15	mice	mouse	NNS
cord-015021-pol2qm74	7136	16	that	that	WDT
cord-015021-pol2qm74	7136	17	have	have	VBP
cord-015021-pol2qm74	7136	18	been	be	VBN
cord-015021-pol2qm74	7136	19	stressed	stress	VBN
cord-015021-pol2qm74	7136	20	by	by	IN
cord-015021-pol2qm74	7136	21	immobilization	immobilization	NN
cord-015021-pol2qm74	7136	22	.	.	.
cord-015021-pol2qm74	7137	1	The	the	DT
cord-015021-pol2qm74	7137	2	proteins	protein	NNS
cord-015021-pol2qm74	7137	3	have	have	VBP
cord-015021-pol2qm74	7137	4	been	be	VBN
cord-015021-pol2qm74	7137	5	labelled	label	VBN
cord-015021-pol2qm74	7137	6	with	with	IN
cord-015021-pol2qm74	7137	7	3sSmethionine	3ssmethionine	CD
cord-015021-pol2qm74	7137	8	in	in	IN
cord-015021-pol2qm74	7137	9	vivo	vivo	NN
cord-015021-pol2qm74	7137	10	and	and	CC
cord-015021-pol2qm74	7137	11	the	the	DT
cord-015021-pol2qm74	7137	12	study	study	NN
cord-015021-pol2qm74	7137	13	was	be	VBD
cord-015021-pol2qm74	7137	14	performed	perform	VBN
cord-015021-pol2qm74	7137	15	by	by	IN
cord-015021-pol2qm74	7137	16	two	two	CD
cord-015021-pol2qm74	7137	17	dimensional	dimensional	JJ
cord-015021-pol2qm74	7137	18	gel	gel	NN
cord-015021-pol2qm74	7137	19	electrophoresis	electrophoresis	NN
cord-015021-pol2qm74	7137	20	based	base	VBN
cord-015021-pol2qm74	7137	21	on	on	IN
cord-015021-pol2qm74	7137	22	the	the	DT
cord-015021-pol2qm74	7137	23	method	method	NN
cord-015021-pol2qm74	7137	24	originally	originally	RB
cord-015021-pol2qm74	7137	25	described	describe	VBN
cord-015021-pol2qm74	7137	26	by	by	IN
cord-015021-pol2qm74	7137	27	O'Farrel	O'Farrel	NNP
cord-015021-pol2qm74	7137	28	.	.	.
cord-015021-pol2qm74	7138	1	The	the	DT
cord-015021-pol2qm74	7138	2	electrophoretic	electrophoretic	JJ
cord-015021-pol2qm74	7138	3	run	run	NN
cord-015021-pol2qm74	7138	4	was	be	VBD
cord-015021-pol2qm74	7138	5	carried	carry	VBN
cord-015021-pol2qm74	7138	6	out	out	RP
cord-015021-pol2qm74	7138	7	in	in	IN
cord-015021-pol2qm74	7138	8	an	an	DT
cord-015021-pol2qm74	7138	9	ISODALT	isodalt	NN
cord-015021-pol2qm74	7138	10	apparatus	apparatus	NN
cord-015021-pol2qm74	7138	11	.	.	.
cord-015021-pol2qm74	7139	1	A	a	DT
cord-015021-pol2qm74	7139	2	Molecular	Molecular	NNP
cord-015021-pol2qm74	7139	3	Dynamics	Dynamics	NNPS
cord-015021-pol2qm74	7139	4	laser	laser	NN
cord-015021-pol2qm74	7139	5	scanner	scanner	NN
cord-015021-pol2qm74	7139	6	and	and	CC
cord-015021-pol2qm74	7139	7	the	the	DT
cord-015021-pol2qm74	7139	8	Kepler	Kepler	NNP
cord-015021-pol2qm74	7139	9	Image	Image	NNP
cord-015021-pol2qm74	7139	10	Analysis	Analysis	NNP
cord-015021-pol2qm74	7139	11	System	System	NNP
cord-015021-pol2qm74	7139	12	(	(	-LRB-
cord-015021-pol2qm74	7139	13	LSB	LSB	NNP
cord-015021-pol2qm74	7139	14	,	,	,
cord-015021-pol2qm74	7139	15	Rockville	Rockville	NNP
cord-015021-pol2qm74	7139	16	,	,	,
cord-015021-pol2qm74	7139	17	USA	USA	NNP
cord-015021-pol2qm74	7139	18	)	)	-RRB-
cord-015021-pol2qm74	7139	19	were	be	VBD
cord-015021-pol2qm74	7139	20	used	use	VBN
cord-015021-pol2qm74	7139	21	for	for	IN
cord-015021-pol2qm74	7139	22	modelling	model	VBG
cord-015021-pol2qm74	7139	23	the	the	DT
cord-015021-pol2qm74	7139	24	radiofluorographic	radiofluorographic	JJ
cord-015021-pol2qm74	7139	25	images	image	NNS
cord-015021-pol2qm74	7139	26	.	.	.
cord-015021-pol2qm74	7140	1	The	the	DT
cord-015021-pol2qm74	7140	2	radiofluorographic	radiofluorographic	JJ
cord-015021-pol2qm74	7140	3	images	image	NNS
cord-015021-pol2qm74	7140	4	of	of	IN
cord-015021-pol2qm74	7140	5	the	the	DT
cord-015021-pol2qm74	7140	6	gels	gel	NNS
cord-015021-pol2qm74	7140	7	from	from	IN
cord-015021-pol2qm74	7140	8	serum	serum	NN
cord-015021-pol2qm74	7140	9	samples	sample	NNS
cord-015021-pol2qm74	7140	10	obtained	obtain	VBN
cord-015021-pol2qm74	7140	11	from	from	IN
cord-015021-pol2qm74	7140	12	mice	mouse	NNS
cord-015021-pol2qm74	7140	13	injected	inject	VBN
cord-015021-pol2qm74	7140	14	with	with	IN
cord-015021-pol2qm74	7140	15	I	-PRON-	PRP
cord-015021-pol2qm74	7140	16	mCi	mCi	NNP
cord-015021-pol2qm74	7140	17	of	of	IN
cord-015021-pol2qm74	7140	18	3SS	3ss	CD
cord-015021-pol2qm74	7140	19	-	-	HYPH
cord-015021-pol2qm74	7140	20	methionine	methionine	NN
cord-015021-pol2qm74	7140	21	reveal	reveal	VBP
cord-015021-pol2qm74	7140	22	about	about	RB
cord-015021-pol2qm74	7140	23	440	440	CD
cord-015021-pol2qm74	7140	24	protein	protein	NN
cord-015021-pol2qm74	7140	25	spots	spot	NNS
cord-015021-pol2qm74	7140	26	,	,	,
cord-015021-pol2qm74	7140	27	from	from	IN
cord-015021-pol2qm74	7140	28	which	which	WDT
cord-015021-pol2qm74	7140	29	a	a	DT
cord-015021-pol2qm74	7140	30	small	small	JJ
cord-015021-pol2qm74	7140	31	fraction	fraction	NN
cord-015021-pol2qm74	7140	32	-about	-about	NN
cord-015021-pol2qm74	7140	33	20are	20are	NN
cord-015021-pol2qm74	7140	34	altered	alter	VBN
cord-015021-pol2qm74	7140	35	in	in	IN
cord-015021-pol2qm74	7140	36	both	both	DT
cord-015021-pol2qm74	7140	37	qualitative	qualitative	JJ
cord-015021-pol2qm74	7140	38	and	and	CC
cord-015021-pol2qm74	7140	39	quantitative	quantitative	JJ
cord-015021-pol2qm74	7140	40	manner	manner	NN
cord-015021-pol2qm74	7140	41	.	.	.
cord-015021-pol2qm74	7141	1	The	the	DT
cord-015021-pol2qm74	7141	2	major	major	JJ
cord-015021-pol2qm74	7141	3	changes	change	NNS
cord-015021-pol2qm74	7141	4	are	be	VBP
cord-015021-pol2qm74	7141	5	in	in	IN
cord-015021-pol2qm74	7141	6	the	the	DT
cord-015021-pol2qm74	7141	7	range	range	NN
cord-015021-pol2qm74	7141	8	of	of	IN
cord-015021-pol2qm74	7141	9	25	25	CD
cord-015021-pol2qm74	7141	10	to	to	TO
cord-015021-pol2qm74	7141	11	60.000	60.000	CD
cord-015021-pol2qm74	7141	12	d.	d.	NNP
cord-015021-pol2qm74	7142	1	The	the	DT
cord-015021-pol2qm74	7142	2	analysis	analysis	NN
cord-015021-pol2qm74	7142	3	displays	display	VBZ
cord-015021-pol2qm74	7142	4	a	a	DT
cord-015021-pol2qm74	7142	5	highly	highly	RB
cord-015021-pol2qm74	7142	6	reproducible	reproducible	JJ
cord-015021-pol2qm74	7142	7	pattern	pattern	NN
cord-015021-pol2qm74	7142	8	,	,	,
cord-015021-pol2qm74	7142	9	where	where	WRB
cord-015021-pol2qm74	7142	10	clear	clear	JJ
cord-015021-pol2qm74	7142	11	differences	difference	NNS
cord-015021-pol2qm74	7142	12	between	between	IN
cord-015021-pol2qm74	7142	13	stressed	stressed	JJ
cord-015021-pol2qm74	7142	14	and	and	CC
cord-015021-pol2qm74	7142	15	non	non	JJ
cord-015021-pol2qm74	7142	16	-	-	JJ
cord-015021-pol2qm74	7142	17	stressed	stress	VBN
cord-015021-pol2qm74	7142	18	conditions	condition	NNS
cord-015021-pol2qm74	7142	19	are	be	VBP
cord-015021-pol2qm74	7142	20	shown	show	VBN
cord-015021-pol2qm74	7142	21	.	.	.
cord-015021-pol2qm74	7143	1	Differences	difference	NNS
cord-015021-pol2qm74	7143	2	between	between	IN
cord-015021-pol2qm74	7143	3	patterns	pattern	NNS
cord-015021-pol2qm74	7143	4	attributed	attribute	VBN
cord-015021-pol2qm74	7143	5	to	to	IN
cord-015021-pol2qm74	7143	6	chronic	chronic	JJ
cord-015021-pol2qm74	7143	7	vs.	vs.	IN
cord-015021-pol2qm74	7143	8	acute	acute	JJ
cord-015021-pol2qm74	7143	9	stress	stress	NN
cord-015021-pol2qm74	7143	10	will	will	MD
cord-015021-pol2qm74	7143	11	be	be	VB
cord-015021-pol2qm74	7143	12	presented	present	VBN
cord-015021-pol2qm74	7143	13	.	.	.
cord-015021-pol2qm74	7144	1	Patients	patient	NNS
cord-015021-pol2qm74	7144	2	with	with	IN
cord-015021-pol2qm74	7144	3	severe	severe	JJ
cord-015021-pol2qm74	7144	4	trauma	trauma	NN
cord-015021-pol2qm74	7144	5	or	or	CC
cord-015021-pol2qm74	7144	6	major	major	JJ
cord-015021-pol2qm74	7144	7	surgery	surgery	NN
cord-015021-pol2qm74	7144	8	are	be	VBP
cord-015021-pol2qm74	7144	9	known	know	VBN
cord-015021-pol2qm74	7144	10	to	to	TO
cord-015021-pol2qm74	7144	11	acquire	acquire	VB
cord-015021-pol2qm74	7144	12	alterations	alteration	NNS
cord-015021-pol2qm74	7144	13	in	in	IN
cord-015021-pol2qm74	7144	14	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7144	15	functions	function	NNS
cord-015021-pol2qm74	7144	16	which	which	WDT
cord-015021-pol2qm74	7144	17	contribute	contribute	VBP
cord-015021-pol2qm74	7144	18	to	to	IN
cord-015021-pol2qm74	7144	19	their	-PRON-	PRP$
cord-015021-pol2qm74	7144	20	enhanced	enhance	VBN
cord-015021-pol2qm74	7144	21	susceptibility	susceptibility	NN
cord-015021-pol2qm74	7144	22	towards	towards	IN
cord-015021-pol2qm74	7144	23	microbial	microbial	JJ
cord-015021-pol2qm74	7144	24	infections	infection	NNS
cord-015021-pol2qm74	7144	25	.	.	.
cord-015021-pol2qm74	7145	1	We	-PRON-	PRP
cord-015021-pol2qm74	7145	2	analyzed	analyze	VBD
cord-015021-pol2qm74	7145	3	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7145	4	functions	function	NNS
cord-015021-pol2qm74	7145	5	from	from	IN
cord-015021-pol2qm74	7145	6	fourty	fourty	CD
cord-015021-pol2qm74	7145	7	patients	patient	NNS
cord-015021-pol2qm74	7145	8	admitted	admit	VBN
cord-015021-pol2qm74	7145	9	for	for	IN
cord-015021-pol2qm74	7145	10	major	major	JJ
cord-015021-pol2qm74	7145	11	surgery	surgery	NN
cord-015021-pol2qm74	7145	12	6	6	CD
cord-015021-pol2qm74	7145	13	days	day	NNS
cord-015021-pol2qm74	7145	14	and	and	CC
cord-015021-pol2qm74	7145	15	1	1	CD
cord-015021-pol2qm74	7145	16	days	day	NNS
cord-015021-pol2qm74	7145	17	preoperatively	preoperatively	RB
cord-015021-pol2qm74	7145	18	and	and	CC
cord-015021-pol2qm74	7145	19	on	on	IN
cord-015021-pol2qm74	7145	20	the	the	DT
cord-015021-pol2qm74	7145	21	ist	ist	NN
cord-015021-pol2qm74	7145	22	and	and	CC
cord-015021-pol2qm74	7145	23	6th	6th	JJ
cord-015021-pol2qm74	7145	24	postoperative	postoperative	JJ
cord-015021-pol2qm74	7145	25	days	day	NNS
cord-015021-pol2qm74	7146	1	(	(	-LRB-
cord-015021-pol2qm74	7146	2	study	study	NN
cord-015021-pol2qm74	7146	3	-	-	HYPH
cord-015021-pol2qm74	7146	4	days	day	NNS
cord-015021-pol2qm74	7146	5	i	i	PRP
cord-015021-pol2qm74	7146	6	,	,	,
cord-015021-pol2qm74	7146	7	2	2	CD
cord-015021-pol2qm74	7146	8	,	,	,
cord-015021-pol2qm74	7146	9	3	3	CD
cord-015021-pol2qm74	7146	10	,	,	,
cord-015021-pol2qm74	7146	11	and	and	CC
cord-015021-pol2qm74	7146	12	4	4	LS
cord-015021-pol2qm74	7146	13	)	)	-RRB-
cord-015021-pol2qm74	7146	14	in	in	IN
cord-015021-pol2qm74	7146	15	a	a	DT
cord-015021-pol2qm74	7146	16	randomized	randomized	JJ
cord-015021-pol2qm74	7146	17	placebo	placebo	NN
cord-015021-pol2qm74	7146	18	-	-	HYPH
cord-015021-pol2qm74	7146	19	controlled	control	VBN
cord-015021-pol2qm74	7146	20	double	double	JJ
cord-015021-pol2qm74	7146	21	-	-	HYPH
cord-015021-pol2qm74	7146	22	blind	blind	JJ
cord-015021-pol2qm74	7146	23	study	study	NN
cord-015021-pol2qm74	7146	24	.	.	.
cord-015021-pol2qm74	7147	1	Patients	patient	NNS
cord-015021-pol2qm74	7147	2	were	be	VBD
cord-015021-pol2qm74	7147	3	divided	divide	VBN
cord-015021-pol2qm74	7147	4	into	into	IN
cord-015021-pol2qm74	7147	5	two	two	CD
cord-015021-pol2qm74	7147	6	groups	group	NNS
cord-015021-pol2qm74	7147	7	,	,	,
cord-015021-pol2qm74	7147	8	one	one	CD
cord-015021-pol2qm74	7147	9	~eceived	~eceived	SYM
cord-015021-pol2qm74	7147	10	6	6	CD
cord-015021-pol2qm74	7147	11	days	day	NNS
cord-015021-pol2qm74	7147	12	preoperatively	preoperatively	RB
cord-015021-pol2qm74	7147	13	an	an	DT
cord-015021-pol2qm74	7147	14	enteral	enteral	JJ
cord-015021-pol2qm74	7147	15	nutrition	nutrition	NN
cord-015021-pol2qm74	7147	16	enriched	enrich	VBN
cord-015021-pol2qm74	7147	17	with	with	IN
cord-015021-pol2qm74	7147	18	omega-3	omega-3	JJ
cord-015021-pol2qm74	7147	19	fatty	fatty	JJ
cord-015021-pol2qm74	7147	20	acids	acid	NNS
cord-015021-pol2qm74	7147	21	,	,	,
cord-015021-pol2qm74	7147	22	arginiee	arginiee	NN
cord-015021-pol2qm74	7147	23	,	,	,
cord-015021-pol2qm74	7147	24	and	and	CC
cord-015021-pol2qm74	7147	25	RNA	RNA	NNP
cord-015021-pol2qm74	7147	26	(	(	-LRB-
cord-015021-pol2qm74	7147	27	IMPACT	IMPACT	NNP
cord-015021-pol2qm74	7147	28	)	)	-RRB-
cord-015021-pol2qm74	7147	29	,	,	,
cord-015021-pol2qm74	7147	30	the	the	DT
cord-015021-pol2qm74	7147	31	other	other	JJ
cord-015021-pol2qm74	7147	32	an	an	DT
cord-015021-pol2qm74	7147	33	isocaloric	isocaloric	JJ
cord-015021-pol2qm74	7147	34	,	,	,
cord-015021-pol2qm74	7147	35	not	not	RB
cord-015021-pol2qm74	7147	36	enriched	enrich	VBN
cord-015021-pol2qm74	7147	37	control	control	NN
cord-015021-pol2qm74	7147	38	nutrition	nutrition	NN
cord-015021-pol2qm74	7147	39	(	(	-LRB-
cord-015021-pol2qm74	7147	40	placebo	placebo	NN
cord-015021-pol2qm74	7147	41	)	)	-RRB-
cord-015021-pol2qm74	7147	42	.	.	.
cord-015021-pol2qm74	7148	1	Meutrophils	meutrophil	NNS
cord-015021-pol2qm74	7148	2	were	be	VBD
cord-015021-pol2qm74	7148	3	isolated	isolate	VBN
cord-015021-pol2qm74	7148	4	from	from	IN
cord-015021-pol2qm74	7148	5	the	the	DT
cord-015021-pol2qm74	7148	6	peripheral	peripheral	JJ
cord-015021-pol2qm74	7148	7	blood	blood	NN
cord-015021-pol2qm74	7148	8	and	and	CC
cord-015021-pol2qm74	7148	9	stimulated	stimulate	VBD
cord-015021-pol2qm74	7148	10	with	with	IN
cord-015021-pol2qm74	7148	11	the	the	DT
cord-015021-pol2qm74	7148	12	Ca	Ca	NNP
cord-015021-pol2qm74	7148	13	-	-	HYPH
cord-015021-pol2qm74	7148	14	ionophor	ionophor	NNP
cord-015021-pol2qm74	7149	1	A23187	A23187	NNP
cord-015021-pol2qm74	7149	2	(	(	-LRB-
cord-015021-pol2qm74	7149	3	7.3	7.3	CD
cord-015021-pol2qm74	7149	4	pM	pm	NN
cord-015021-pol2qm74	7149	5	)	)	-RRB-
cord-015021-pol2qm74	7149	6	.	.	.
cord-015021-pol2qm74	7150	1	The	the	DT
cord-015021-pol2qm74	7150	2	capacity	capacity	NN
cord-015021-pol2qm74	7150	3	of	of	IN
cord-015021-pol2qm74	7150	4	the	the	DT
cord-015021-pol2qm74	7150	5	respective	respective	JJ
cord-015021-pol2qm74	7150	6	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7150	7	to	to	TO
cord-015021-pol2qm74	7150	8	generate	generate	VB
cord-015021-pol2qm74	7150	9	leukotrienes	leukotriene	NNS
cord-015021-pol2qm74	7150	10	was	be	VBD
cord-015021-pol2qm74	7150	11	analyzed	analyze	VBN
cord-015021-pol2qm74	7150	12	by	by	IN
cord-015021-pol2qm74	7150	13	RP	RP	NNP
cord-015021-pol2qm74	7150	14	-	-	HYPH
cord-015021-pol2qm74	7150	15	HPLC	HPLC	NNP
cord-015021-pol2qm74	7150	16	.	.	.
cord-015021-pol2qm74	7151	1	Neutrophils	neutrophils	NN
cord-015021-pol2qm74	7151	2	from	from	IN
cord-015021-pol2qm74	7151	3	IMPACT	impact	NN
cord-015021-pol2qm74	7151	4	group	group	NN
cord-015021-pol2qm74	7151	5	generated	generate	VBD
cord-015021-pol2qm74	7151	6	significantly	significantly	RB
cord-015021-pol2qm74	7151	7	higher	high	JJR
cord-015021-pol2qm74	7151	8	amounts	amount	NNS
cord-015021-pol2qm74	7151	9	of	of	IN
cord-015021-pol2qm74	7151	10	LTB5	LTB5	NNP
cord-015021-pol2qm74	7151	11	(	(	-LRB-
cord-015021-pol2qm74	7151	12	mean	mean	VB
cord-015021-pol2qm74	7151	13	values	value	NNS
cord-015021-pol2qm74	7151	14	6.6	6.6	CD
cord-015021-pol2qm74	7151	15	ng	ng	NN
cord-015021-pol2qm74	7151	16	/	/	SYM
cord-015021-pol2qm74	7151	17	l	l	NN
cord-015021-pol2qm74	7151	18	x	x	NNP
cord-015021-pol2qm74	7151	19	i~	i~	CD
cord-015021-pol2qm74	7151	20	cells	cell	NNS
cord-015021-pol2qm74	7151	21	)	)	-RRB-
cord-015021-pol2qm74	7151	22	compared	compare	VBN
cord-015021-pol2qm74	7151	23	to	to	IN
cord-015021-pol2qm74	7151	24	the	the	DT
cord-015021-pol2qm74	7151	25	placebo	placebo	NN
cord-015021-pol2qm74	7151	26	group	group	NN
cord-015021-pol2qm74	7151	27	(	(	-LRB-
cord-015021-pol2qm74	7151	28	2.6	2.6	CD
cord-015021-pol2qm74	7151	29	ng	ng	NN
cord-015021-pol2qm74	7151	30	)	)	-RRB-
cord-015021-pol2qm74	7151	31	at	at	IN
cord-015021-pol2qm74	7151	32	study	study	NN
cord-015021-pol2qm74	7151	33	-	-	HYPH
cord-015021-pol2qm74	7151	34	day	day	NN
cord-015021-pol2qm74	7151	35	2	2	CD
cord-015021-pol2qm74	7151	36	[	[	-LRB-
cord-015021-pol2qm74	7151	37	p	p	NN
cord-015021-pol2qm74	7151	38	,	,	,
cord-015021-pol2qm74	7151	39	0.01	0.01	CD
cord-015021-pol2qm74	7151	40	)	)	-RRB-
cord-015021-pol2qm74	7151	41	.	.	.
cord-015021-pol2qm74	7152	1	In	in	IN
cord-015021-pol2qm74	7152	2	contrast	contrast	NN
cord-015021-pol2qm74	7152	3	,	,	,
cord-015021-pol2qm74	7152	4	the	the	DT
cord-015021-pol2qm74	7152	5	capacity	capacity	NN
cord-015021-pol2qm74	7152	6	of	of	IN
cord-015021-pol2qm74	7152	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7152	8	to	to	TO
cord-015021-pol2qm74	7152	9	produce	produce	VB
cord-015021-pol2qm74	7152	10	LTB4	LTB4	NNP
cord-015021-pol2qm74	7152	11	was	be	VBD
cord-015021-pol2qm74	7152	12	not	not	RB
cord-015021-pol2qm74	7152	13	significantly	significantly	RB
cord-015021-pol2qm74	7152	14	different	different	JJ
cord-015021-pol2qm74	7152	15	in	in	IN
cord-015021-pol2qm74	7152	16	both	both	DT
cord-015021-pol2qm74	7152	17	patients	patient	NNS
cord-015021-pol2qm74	7152	18	populations	population	NNS
cord-015021-pol2qm74	7152	19	at	at	IN
cord-015021-pol2qm74	7152	20	study	study	NN
cord-015021-pol2qm74	7152	21	-	-	HYPH
cord-015021-pol2qm74	7152	22	days	day	NNS
cord-015021-pol2qm74	7152	23	2	2	CD
cord-015021-pol2qm74	7152	24	and	and	CC
cord-015021-pol2qm74	7152	25	3	3	CD
cord-015021-pol2qm74	7152	26	.	.	.
cord-015021-pol2qm74	7153	1	The	the	DT
cord-015021-pol2qm74	7153	2	omega	omega	NN
cord-015021-pol2qm74	7153	3	-	-	HYPH
cord-015021-pol2qm74	7153	4	oxidation	oxidation	NN
cord-015021-pol2qm74	7153	5	of	of	IN
cord-015021-pol2qm74	7153	6	LTB4	LTB4	NNP
cord-015021-pol2qm74	7153	7	to	to	IN
cord-015021-pol2qm74	7153	8	its	-PRON-	PRP$
cord-015021-pol2qm74	7153	9	biologically	biologically	RB
cord-015021-pol2qm74	7153	10	less	less	RBR
cord-015021-pol2qm74	7153	11	active	active	JJ
cord-015021-pol2qm74	7153	12	metabolites	metabolite	NNS
cord-015021-pol2qm74	7153	13	OH	OH	NNP
cord-015021-pol2qm74	7153	14	-	-	HYPH
cord-015021-pol2qm74	7153	15	LTB4	LTB4	NNP
cord-015021-pol2qm74	7153	16	and	and	CC
cord-015021-pol2qm74	7153	17	COOH	COOH	NNP
cord-015021-pol2qm74	7153	18	-	-	HYPH
cord-015021-pol2qm74	7153	19	LTB4	LTB4	NNP
cord-015021-pol2qm74	7153	20	was	be	VBD
cord-015021-pol2qm74	7153	21	not	not	RB
cord-015021-pol2qm74	7153	22	significantly	significantly	RB
cord-015021-pol2qm74	7153	23	different	different	JJ
cord-015021-pol2qm74	7153	24	in	in	IN
cord-015021-pol2qm74	7153	25	both	both	DT
cord-015021-pol2qm74	7153	26	groups	group	NNS
cord-015021-pol2qm74	7153	27	.	.	.
cord-015021-pol2qm74	7154	1	However	however	RB
cord-015021-pol2qm74	7154	2	,	,	,
cord-015021-pol2qm74	7154	3	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7154	4	from	from	IN
cord-015021-pol2qm74	7154	5	group	group	NN
cord-015021-pol2qm74	7154	6	F	F	NNP
cord-015021-pol2qm74	7154	7	patients	patient	NNS
cord-015021-pol2qm74	7154	8	generate	generate	VBP
cord-015021-pol2qm74	7154	9	more	more	JJR
cord-015021-pol2qm74	7154	10	LTC4	LTC4	NNP
cord-015021-pol2qm74	7154	11	at	at	IN
cord-015021-pol2qm74	7154	12	study	study	NN
cord-015021-pol2qm74	7154	13	-	-	HYPH
cord-015021-pol2qm74	7154	14	day	day	NN
cord-015021-pol2qm74	7154	15	2	2	CD
cord-015021-pol2qm74	7154	16	(	(	-LRB-
cord-015021-pol2qm74	7154	17	p(0/5	p(0/5	NNP
cord-015021-pol2qm74	7154	18	)	)	-RRB-
cord-015021-pol2qm74	7154	19	.	.	.
cord-015021-pol2qm74	7155	1	The	the	DT
cord-015021-pol2qm74	7155	2	capacity	capacity	NN
cord-015021-pol2qm74	7155	3	of	of	IN
cord-015021-pol2qm74	7155	4	the	the	DT
cord-015021-pol2qm74	7155	5	patients'neutrophils	patients'neutrophil	NNS
cord-015021-pol2qm74	7155	6	to	to	TO
cord-015021-pol2qm74	7155	7	generate	generate	VB
cord-015021-pol2qm74	7155	8	reactive	reactive	JJ
cord-015021-pol2qm74	7155	9	oxygen	oxygen	NN
cord-015021-pol2qm74	7155	10	radicals	radical	NNS
cord-015021-pol2qm74	7155	11	upon	upon	IN
cord-015021-pol2qm74	7155	12	stimulation	stimulation	NN
cord-015021-pol2qm74	7155	13	with	with	IN
cord-015021-pol2qm74	7155	14	fMLP	fmlp	NN
cord-015021-pol2qm74	7155	15	,	,	,
cord-015021-pol2qm74	7155	16	PMA	PMA	NNP
cord-015021-pol2qm74	7155	17	or	or	CC
cord-015021-pol2qm74	7155	18	the	the	DT
cord-015021-pol2qm74	7155	19	Caionopbore	Caionopbore	NNP
cord-015021-pol2qm74	7155	20	A23187	A23187	NNP
cord-015021-pol2qm74	7155	21	exhibited	exhibit	VBD
cord-015021-pol2qm74	7155	22	patient	patient	JJ
cord-015021-pol2qm74	7155	23	dependent	dependent	JJ
cord-015021-pol2qm74	7155	24	differences	difference	NNS
cord-015021-pol2qm74	7155	25	but	but	CC
cord-015021-pol2qm74	7155	26	no	no	DT
cord-015021-pol2qm74	7155	27	correlations	correlation	NNS
cord-015021-pol2qm74	7155	28	to	to	IN
cord-015021-pol2qm74	7155	29	the	the	DT
cord-015021-pol2qm74	7155	30	repective	repective	JJ
cord-015021-pol2qm74	7155	31	nutritional	nutritional	JJ
cord-015021-pol2qm74	7155	32	supplementation	supplementation	NN
cord-015021-pol2qm74	7155	33	as	as	IN
cord-015021-pol2qm74	7155	34	was	be	VBD
cord-015021-pol2qm74	7155	35	measured	measure	VBN
cord-015021-pol2qm74	7155	36	by	by	IN
cord-015021-pol2qm74	7155	37	luminol	luminol	NN
cord-015021-pol2qm74	7155	38	dependent	dependent	JJ
cord-015021-pol2qm74	7155	39	ohemiluminescense=	ohemiluminescense=	RB
cord-015021-pol2qm74	7156	1	These	these	DT
cord-015021-pol2qm74	7156	2	data	datum	NNS
cord-015021-pol2qm74	7156	3	indicate	indicate	VBP
cord-015021-pol2qm74	7156	4	that	that	IN
cord-015021-pol2qm74	7156	5	an	an	DT
cord-015021-pol2qm74	7156	6	enteral	enteral	JJ
cord-015021-pol2qm74	7156	7	nutrition	nutrition	NN
cord-015021-pol2qm74	7156	8	enriched	enrich	VBN
cord-015021-pol2qm74	7156	9	in	in	IN
cord-015021-pol2qm74	7156	10	omega-3	omega-3	JJ
cord-015021-pol2qm74	7156	11	fatty	fatty	JJ
cord-015021-pol2qm74	7156	12	acids	acid	NNS
cord-015021-pol2qm74	7156	13	lead	lead	VBP
cord-015021-pol2qm74	7156	14	to	to	IN
cord-015021-pol2qm74	7156	15	alterations	alteration	NNS
cord-015021-pol2qm74	7156	16	in	in	IN
cord-015021-pol2qm74	7156	17	distinct	distinct	JJ
cord-015021-pol2qm74	7156	18	parameters	parameter	NNS
cord-015021-pol2qm74	7156	19	of	of	IN
cord-015021-pol2qm74	7156	20	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7156	21	functions	function	NNS
cord-015021-pol2qm74	7156	22	.	.	.
cord-015021-pol2qm74	7157	1	Clinical	clinical	JJ
cord-015021-pol2qm74	7157	2	patient	patient	NN
cord-015021-pol2qm74	7157	3	characteristics	characteristic	NNS
cord-015021-pol2qm74	7157	4	and	and	CC
cord-015021-pol2qm74	7157	5	mean	mean	VB
cord-015021-pol2qm74	7157	6	caloric	caloric	JJ
cord-015021-pol2qm74	7157	7	intake	intake	NN
cord-015021-pol2qm74	7157	8	were	be	VBD
cord-015021-pol2qm74	7157	9	similar	similar	JJ
cord-015021-pol2qm74	7157	10	between	between	IN
cord-015021-pol2qm74	7157	11	the	the	DT
cord-015021-pol2qm74	7157	12	two	two	CD
cord-015021-pol2qm74	7157	13	groups	group	NNS
cord-015021-pol2qm74	7157	14	.	.	.
cord-015021-pol2qm74	7158	1	Both	both	DT
cord-015021-pol2qm74	7158	2	formula	formula	NN
cord-015021-pol2qm74	7158	3	were	be	VBD
cord-015021-pol2qm74	7158	4	tolerated	tolerate	VBN
cord-015021-pol2qm74	7158	5	well	well	RB
cord-015021-pol2qm74	7158	6	and	and	CC
cord-015021-pol2qm74	7158	7	the	the	DT
cord-015021-pol2qm74	7158	8	incidence	incidence	NN
cord-015021-pol2qm74	7158	9	of	of	IN
cord-015021-pol2qm74	7158	10	diarrhea	diarrhea	NN
cord-015021-pol2qm74	7158	11	was	be	VBD
cord-015021-pol2qm74	7158	12	low	low	JJ
cord-015021-pol2qm74	7158	13	.	.	.
cord-015021-pol2qm74	7159	1	The	the	DT
cord-015021-pol2qm74	7159	2	number	number	NN
cord-015021-pol2qm74	7159	3	of	of	IN
cord-015021-pol2qm74	7159	4	infectious	infectious	JJ
cord-015021-pol2qm74	7159	5	and	and	CC
cord-015021-pol2qm74	7159	6	wound	wound	JJ
cord-015021-pol2qm74	7159	7	complications	complication	NNS
cord-015021-pol2qm74	7159	8	as	as	RB
cord-015021-pol2qm74	7159	9	well	well	RB
cord-015021-pol2qm74	7159	10	as	as	IN
cord-015021-pol2qm74	7159	11	the	the	DT
cord-015021-pol2qm74	7159	12	APACHE	APACHE	NNP
cord-015021-pol2qm74	7159	13	II	II	NNP
cord-015021-pol2qm74	7159	14	score	score	NN
cord-015021-pol2qm74	7159	15	was	be	VBD
cord-015021-pol2qm74	7159	16	evaluated	evaluate	VBN
cord-015021-pol2qm74	7159	17	for	for	IN
cord-015021-pol2qm74	7159	18	the	the	DT
cord-015021-pol2qm74	7159	19	two	two	CD
cord-015021-pol2qm74	7159	20	study	study	NN
cord-015021-pol2qm74	7159	21	groups	group	NNS
cord-015021-pol2qm74	7159	22	.	.	.
cord-015021-pol2qm74	7160	1	Although	although	IN
cord-015021-pol2qm74	7160	2	the	the	DT
cord-015021-pol2qm74	7160	3	number	number	NN
cord-015021-pol2qm74	7160	4	of	of	IN
cord-015021-pol2qm74	7160	5	complications	complication	NNS
cord-015021-pol2qm74	7160	6	in	in	IN
cord-015021-pol2qm74	7160	7	the	the	DT
cord-015021-pol2qm74	7160	8	group	group	NN
cord-015021-pol2qm74	7160	9	supplemented	supplement	VBN
cord-015021-pol2qm74	7160	10	with	with	IN
cord-015021-pol2qm74	7160	11	arginine	arginine	NN
cord-015021-pol2qm74	7160	12	,	,	,
cord-015021-pol2qm74	7160	13	RNA	RNA	NNP
cord-015021-pol2qm74	7160	14	and	and	CC
cord-015021-pol2qm74	7160	15	omega-3	omega-3	JJ
cord-015021-pol2qm74	7160	16	fatty	fatty	JJ
cord-015021-pol2qm74	7160	17	acids	acid	NNS
cord-015021-pol2qm74	7160	18	was	be	VBD
cord-015021-pol2qm74	7160	19	lower	low	JJR
cord-015021-pol2qm74	7160	20	no	no	DT
cord-015021-pol2qm74	7160	21	significant	significant	JJ
cord-015021-pol2qm74	7160	22	difference	difference	NN
cord-015021-pol2qm74	7160	23	in	in	IN
cord-015021-pol2qm74	7160	24	the	the	DT
cord-015021-pol2qm74	7160	25	occurance	occurance	NN
cord-015021-pol2qm74	7160	26	of	of	IN
cord-015021-pol2qm74	7160	27	infectious	infectious	JJ
cord-015021-pol2qm74	7160	28	and	and	CC
cord-015021-pol2qm74	7160	29	wound	wound	JJ
cord-015021-pol2qm74	7160	30	complications	complication	NNS
cord-015021-pol2qm74	7160	31	has	have	VBZ
cord-015021-pol2qm74	7160	32	been	be	VBN
cord-015021-pol2qm74	7160	33	observed	observe	VBN
cord-015021-pol2qm74	7160	34	between	between	IN
cord-015021-pol2qm74	7160	35	the	the	DT
cord-015021-pol2qm74	7160	36	two	two	CD
cord-015021-pol2qm74	7160	37	groups	group	NNS
cord-015021-pol2qm74	7160	38	.	.	.
cord-015021-pol2qm74	7161	1	However	however	RB
cord-015021-pol2qm74	7161	2	,	,	,
cord-015021-pol2qm74	7161	3	the	the	DT
cord-015021-pol2qm74	7161	4	APACHE	APACHE	NNP
cord-015021-pol2qm74	7161	5	II	II	NNP
cord-015021-pol2qm74	7161	6	score	score	NN
cord-015021-pol2qm74	7161	7	indicated	indicate	VBD
cord-015021-pol2qm74	7161	8	a	a	DT
cord-015021-pol2qm74	7161	9	significantly	significantly	RB
cord-015021-pol2qm74	7161	10	improved	improve	VBN
cord-015021-pol2qm74	7161	11	clinical	clinical	JJ
cord-015021-pol2qm74	7161	12	outcome	outcome	NN
cord-015021-pol2qm74	7161	13	in	in	IN
cord-015021-pol2qm74	7161	14	patients	patient	NNS
cord-015021-pol2qm74	7161	15	with	with	IN
cord-015021-pol2qm74	7161	16	supplemented	supplement	VBN
cord-015021-pol2qm74	7161	17	diet	diet	NN
cord-015021-pol2qm74	7161	18	.	.	.
cord-015021-pol2qm74	7162	1	In	in	IN
cord-015021-pol2qm74	7162	2	conclusion	conclusion	NN
cord-015021-pol2qm74	7162	3	,	,	,
cord-015021-pol2qm74	7162	4	early	early	JJ
cord-015021-pol2qm74	7162	5	enteral	enteral	JJ
cord-015021-pol2qm74	7162	6	nutrition	nutrition	NN
cord-015021-pol2qm74	7162	7	with	with	IN
cord-015021-pol2qm74	7162	8	an	an	DT
cord-015021-pol2qm74	7162	9	arginine	arginine	NN
cord-015021-pol2qm74	7162	10	,	,	,
cord-015021-pol2qm74	7162	11	omega-3	omega-3	JJ
cord-015021-pol2qm74	7162	12	fatty	fatty	JJ
cord-015021-pol2qm74	7162	13	acids	acid	NNS
cord-015021-pol2qm74	7162	14	and	and	CC
cord-015021-pol2qm74	7162	15	RNA	RNA	NNP
cord-015021-pol2qm74	7162	16	supplemented	supplement	VBD
cord-015021-pol2qm74	7162	17	diet	diet	NN
cord-015021-pol2qm74	7162	18	helps	help	VBZ
cord-015021-pol2qm74	7162	19	to	to	TO
cord-015021-pol2qm74	7162	20	recover	recover	VB
cord-015021-pol2qm74	7162	21	more	more	RBR
cord-015021-pol2qm74	7162	22	rapidly	rapidly	RB
cord-015021-pol2qm74	7162	23	after	after	IN
cord-015021-pol2qm74	7162	24	surgical	surgical	JJ
cord-015021-pol2qm74	7162	25	Total	total	JJ
cord-015021-pol2qm74	7162	26	parenteral	parenteral	JJ
cord-015021-pol2qm74	7162	27	nutrition	nutrition	NN
cord-015021-pol2qm74	7163	1	(	(	-LRB-
cord-015021-pol2qm74	7163	2	TPN	TPN	NNP
cord-015021-pol2qm74	7163	3	}	}	-RRB-
cord-015021-pol2qm74	7163	4	is	be	VBZ
cord-015021-pol2qm74	7163	5	associated	associate	VBN
cord-015021-pol2qm74	7163	6	with	with	IN
cord-015021-pol2qm74	7163	7	intestinal	intestinal	JJ
cord-015021-pol2qm74	7163	8	atrophy	atrophy	NN
cord-015021-pol2qm74	7163	9	and	and	CC
cord-015021-pol2qm74	7163	10	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7163	11	attributed	attribute	VBN
cord-015021-pol2qm74	7163	12	to	to	IN
cord-015021-pol2qm74	7163	13	the	the	DT
cord-015021-pol2qm74	7163	14	absence	absence	NN
cord-015021-pol2qm74	7163	15	of	of	IN
cord-015021-pol2qm74	7163	16	the	the	DT
cord-015021-pol2qm74	7163	17	non	non	JJ
cord-015021-pol2qm74	7163	18	-	-	JJ
cord-015021-pol2qm74	7163	19	essential	essential	JJ
cord-015021-pol2qm74	7163	20	amino	amino	NN
cord-015021-pol2qm74	7163	21	acid	acid	NN
cord-015021-pol2qm74	7163	22	glutamine	glutamine	NN
cord-015021-pol2qm74	7163	23	in	in	IN
cord-015021-pol2qm74	7163	24	current	current	JJ
cord-015021-pol2qm74	7163	25	parenteral	parenteral	JJ
cord-015021-pol2qm74	7163	26	nutrition	nutrition	NN
cord-015021-pol2qm74	7163	27	solutions	solution	NNS
cord-015021-pol2qm74	7163	28	.	.	.
cord-015021-pol2qm74	7164	1	In	in	IN
cord-015021-pol2qm74	7164	2	this	this	DT
cord-015021-pol2qm74	7164	3	animal	animal	NN
cord-015021-pol2qm74	7164	4	study	study	NN
cord-015021-pol2qm74	7164	5	with	with	IN
cord-015021-pol2qm74	7164	6	18	18	CD
cord-015021-pol2qm74	7164	7	male	male	JJ
cord-015021-pol2qm74	7164	8	Wistar	Wistar	NNP
cord-015021-pol2qm74	7164	9	-	-	HYPH
cord-015021-pol2qm74	7164	10	rats	rat	NNS
cord-015021-pol2qm74	7164	11	we	-PRON-	PRP
cord-015021-pol2qm74	7164	12	tested	test	VBD
cord-015021-pol2qm74	7164	13	the	the	DT
cord-015021-pol2qm74	7164	14	hypothesis	hypothesis	NN
cord-015021-pol2qm74	7164	15	that	that	IN
cord-015021-pol2qm74	7164	16	glutamine	glutamine	NN
cord-015021-pol2qm74	7164	17	-	-	HYPH
cord-015021-pol2qm74	7164	18	dipeptide	dipeptide	NN
cord-015021-pol2qm74	7164	19	supplementation	supplementation	NN
cord-015021-pol2qm74	7164	20	during	during	IN
cord-015021-pol2qm74	7164	21	TPN	TPN	NNP
cord-015021-pol2qm74	7164	22	for	for	IN
cord-015021-pol2qm74	7164	23	10	10	CD
cord-015021-pol2qm74	7164	24	days	day	NNS
cord-015021-pol2qm74	7164	25	would	would	MD
cord-015021-pol2qm74	7164	26	restore	restore	VB
cord-015021-pol2qm74	7164	27	small	small	JJ
cord-015021-pol2qm74	7164	28	bowel	bowel	NN
cord-015021-pol2qm74	7164	29	atrophy	atrophy	NN
cord-015021-pol2qm74	7164	30	and	and	CC
cord-015021-pol2qm74	7164	31	TPN	TPN	NNP
cord-015021-pol2qm74	7164	32	induced	induce	VBN
cord-015021-pol2qm74	7164	33	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7164	34	.	.	.
cord-015021-pol2qm74	7165	1	A	a	DT
cord-015021-pol2qm74	7165	2	conventional	conventional	JJ
cord-015021-pol2qm74	7165	3	TPN	TPN	NNP
cord-015021-pol2qm74	7165	4	solution	solution	NN
cord-015021-pol2qm74	7165	5	(	(	-LRB-
cord-015021-pol2qm74	7165	6	250	250	CD
cord-015021-pol2qm74	7165	7	Kcai	Kcai	NNP
cord-015021-pol2qm74	7165	8	/	/	SYM
cord-015021-pol2qm74	7165	9	kg	kg	NNP
cord-015021-pol2qm74	7165	10	bw	bw	NNP
cord-015021-pol2qm74	7165	11	)	)	-RRB-
cord-015021-pol2qm74	7165	12	was	be	VBD
cord-015021-pol2qm74	7165	13	compared	compare	VBN
cord-015021-pol2qm74	7165	14	to	to	IN
cord-015021-pol2qm74	7165	15	an	an	DT
cord-015021-pol2qm74	7165	16	isocaloric	isocaloric	JJ
cord-015021-pol2qm74	7165	17	and	and	CC
cord-015021-pol2qm74	7165	18	isonitrogenous	isonitrogenous	JJ
cord-015021-pol2qm74	7165	19	TPN	TPN	NNP
cord-015021-pol2qm74	7165	20	(	(	-LRB-
cord-015021-pol2qm74	7165	21	0,5	0,5	CD
cord-015021-pol2qm74	7165	22	g	g	NN
cord-015021-pol2qm74	7165	23	N	N	NNP
cord-015021-pol2qm74	7165	24	/	/	SYM
cord-015021-pol2qm74	7165	25	animal	animal	NN
cord-015021-pol2qm74	7165	26	/	/	SYM
cord-015021-pol2qm74	7165	27	d	d	NN
cord-015021-pol2qm74	7165	28	)	)	-RRB-
cord-015021-pol2qm74	7165	29	supplemented	supplement	VBN
cord-015021-pol2qm74	7165	30	with	with	IN
cord-015021-pol2qm74	7165	31	alanin	alanin	NNS
cord-015021-pol2qm74	7165	32	-	-	HYPH
cord-015021-pol2qm74	7165	33	glutamin	glutamin	NNP
cord-015021-pol2qm74	7165	34	(	(	-LRB-
cord-015021-pol2qm74	7165	35	Ala	ala	NN
cord-015021-pol2qm74	7165	36	-	-	HYPH
cord-015021-pol2qm74	7165	37	GIn	GIn	NNS
cord-015021-pol2qm74	7165	38	)	)	-RRB-
cord-015021-pol2qm74	7165	39	dipeptide	dipeptide	NNP
cord-015021-pol2qm74	7165	40	(	(	-LRB-
cord-015021-pol2qm74	7165	41	0,15	0,15	NNP
cord-015021-pol2qm74	7165	42	g	g	NNP
cord-015021-pol2qm74	7165	43	N	n	CD
cord-015021-pol2qm74	7165	44	derived	derive	VBN
cord-015021-pol2qm74	7165	45	from	from	IN
cord-015021-pol2qm74	7165	46	Ala	Ala	NNP
cord-015021-pol2qm74	7165	47	-	-	HYPH
cord-015021-pol2qm74	7165	48	GIn	GIn	NNS
cord-015021-pol2qm74	7165	49	=	=	SYM
cord-015021-pol2qm74	7165	50	30	30	CD
cord-015021-pol2qm74	7165	51	%	%	NN
cord-015021-pol2qm74	7165	52	GIn	GIn	NNS
cord-015021-pol2qm74	7165	53	-	-	HYPH
cord-015021-pol2qm74	7165	54	N	N	NNP
cord-015021-pol2qm74	7165	55	)	)	-RRB-
cord-015021-pol2qm74	7165	56	.	.	.
cord-015021-pol2qm74	7166	1	An	an	DT
cord-015021-pol2qm74	7166	2	enteral	enteral	NN
cord-015021-pol2qm74	7166	3	fed	fed	NNP
cord-015021-pol2qm74	7166	4	cqntrol	cqntrol	NNP
cord-015021-pol2qm74	7166	5	group	group	NNP
cord-015021-pol2qm74	7166	6	was	be	VBD
cord-015021-pol2qm74	7166	7	included	include	VBN
cord-015021-pol2qm74	7166	8	.	.	.
cord-015021-pol2qm74	7167	1	Mucosal	Mucosal	NNP
cord-015021-pol2qm74	7167	2	thickness	thickness	NN
cord-015021-pol2qm74	7167	3	,	,	,
cord-015021-pol2qm74	7167	4	villous	villous	NNP
cord-015021-pol2qm74	7167	5	height	height	NN
cord-015021-pol2qm74	7167	6	and	and	CC
cord-015021-pol2qm74	7167	7	architecture	architecture	NN
cord-015021-pol2qm74	7167	8	,	,	,
cord-015021-pol2qm74	7167	9	absorption	absorption	NN
cord-015021-pol2qm74	7167	10	of	of	IN
cord-015021-pol2qm74	7167	11	water	water	NN
cord-015021-pol2qm74	7167	12	and	and	CC
cord-015021-pol2qm74	7167	13	glucose	glucose	NN
cord-015021-pol2qm74	7167	14	as	as	RB
cord-015021-pol2qm74	7167	15	well	well	RB
cord-015021-pol2qm74	7167	16	as	as	IN
cord-015021-pol2qm74	7167	17	dissacharidase	dissacharidase	NN
cord-015021-pol2qm74	7167	18	activity	activity	NN
cord-015021-pol2qm74	7167	19	of	of	IN
cord-015021-pol2qm74	7167	20	maltase	maltase	NN
cord-015021-pol2qm74	7167	21	and	and	CC
cord-015021-pol2qm74	7167	22	alkaline	alkaline	JJ
cord-015021-pol2qm74	7167	23	phosphatase	phosphatase	NN
cord-015021-pol2qm74	7167	24	were	be	VBD
cord-015021-pol2qm74	7167	25	evaluated	evaluate	VBN
cord-015021-pol2qm74	7167	26	.	.	.
cord-015021-pol2qm74	7168	1	Total	total	JJ
cord-015021-pol2qm74	7168	2	parenteral	parenteral	JJ
cord-015021-pol2qm74	7168	3	nutrition	nutrition	NN
cord-015021-pol2qm74	7168	4	in	in	IN
cord-015021-pol2qm74	7168	5	rats	rat	NNS
cord-015021-pol2qm74	7168	6	causes	cause	VBZ
cord-015021-pol2qm74	7168	7	villous	villous	NNP
cord-015021-pol2qm74	7168	8	atrophy	atrophy	NN
cord-015021-pol2qm74	7168	9	,	,	,
cord-015021-pol2qm74	7168	10	a	a	DT
cord-015021-pol2qm74	7168	11	significantly	significantly	RB
cord-015021-pol2qm74	7168	12	reduced	reduce	VBN
cord-015021-pol2qm74	7168	13	absorption	absorption	NN
cord-015021-pol2qm74	7168	14	rate	rate	NN
cord-015021-pol2qm74	7168	15	and	and	CC
cord-015021-pol2qm74	7168	16	a	a	DT
cord-015021-pol2qm74	7168	17	decreased	decreased	JJ
cord-015021-pol2qm74	7168	18	activity	activity	NN
cord-015021-pol2qm74	7168	19	of	of	IN
cord-015021-pol2qm74	7168	20	villous	villous	NNP
cord-015021-pol2qm74	7168	21	enzymes	enzyme	NNS
cord-015021-pol2qm74	7168	22	compared	compare	VBN
cord-015021-pol2qm74	7168	23	to	to	IN
cord-015021-pol2qm74	7168	24	an	an	DT
cord-015021-pol2qm74	7168	25	enteral	enteral	NN
cord-015021-pol2qm74	7168	26	fed	feed	VBN
cord-015021-pol2qm74	7168	27	control	control	NN
cord-015021-pol2qm74	7168	28	(	(	-LRB-
cord-015021-pol2qm74	7168	29	p	p	NN
cord-015021-pol2qm74	7168	30	<	<	XX
cord-015021-pol2qm74	7168	31	O,01	O,01	NNP
cord-015021-pol2qm74	7168	32	)	)	-RRB-
cord-015021-pol2qm74	7168	33	.	.	.
cord-015021-pol2qm74	7169	1	Addition	addition	NN
cord-015021-pol2qm74	7169	2	of	of	IN
cord-015021-pol2qm74	7169	3	Ala	Ala	NNP
cord-015021-pol2qm74	7169	4	-	-	:
cord-015021-pol2qm74	7169	5	GIn	GIn	NNS
cord-015021-pol2qm74	7169	6	to	to	IN
cord-015021-pol2qm74	7169	7	parenteral	parenteral	JJ
cord-015021-pol2qm74	7169	8	nutrition	nutrition	NN
cord-015021-pol2qm74	7169	9	solutions	solution	NNS
cord-015021-pol2qm74	7169	10	prevents	prevent	VBZ
cord-015021-pol2qm74	7169	11	intestinal	intestinal	JJ
cord-015021-pol2qm74	7169	12	atrophy	atrophy	NN
cord-015021-pol2qm74	7169	13	and	and	CC
cord-015021-pol2qm74	7169	14	restores	restore	VBZ
cord-015021-pol2qm74	7169	15	functional	functional	JJ
cord-015021-pol2qm74	7169	16	alterations	alteration	NNS
cord-015021-pol2qm74	7169	17	with	with	IN
cord-015021-pol2qm74	7169	18	a	a	DT
cord-015021-pol2qm74	7169	19	significantly	significantly	RB
cord-015021-pol2qm74	7169	20	increased	increase	VBN
cord-015021-pol2qm74	7169	21	rate	rate	NN
cord-015021-pol2qm74	7169	22	of	of	IN
cord-015021-pol2qm74	7169	23	water	water	NN
cord-015021-pol2qm74	7169	24	and	and	CC
cord-015021-pol2qm74	7169	25	glucose	glucose	NN
cord-015021-pol2qm74	7169	26	absorption	absorption	NN
cord-015021-pol2qm74	7169	27	as	as	RB
cord-015021-pol2qm74	7169	28	well	well	RB
cord-015021-pol2qm74	7169	29	as	as	IN
cord-015021-pol2qm74	7169	30	a	a	DT
cord-015021-pol2qm74	7169	31	higher	high	JJR
cord-015021-pol2qm74	7169	32	dissacharidase	dissacharidase	NN
cord-015021-pol2qm74	7169	33	activity	activity	NN
cord-015021-pol2qm74	7169	34	compared	compare	VBN
cord-015021-pol2qm74	7169	35	to	to	IN
cord-015021-pol2qm74	7169	36	the	the	DT
cord-015021-pol2qm74	7169	37	standard	standard	JJ
cord-015021-pol2qm74	7169	38	TPN	TPN	NNP
cord-015021-pol2qm74	7169	39	group	group	NN
cord-015021-pol2qm74	7169	40	(	(	-LRB-
cord-015021-pol2qm74	7169	41	p<0,01	p<0,01	NN
cord-015021-pol2qm74	7169	42	)	)	-RRB-
cord-015021-pol2qm74	7169	43	.	.	.
cord-015021-pol2qm74	7170	1	There	there	EX
cord-015021-pol2qm74	7170	2	was	be	VBD
cord-015021-pol2qm74	7170	3	no	no	DT
cord-015021-pol2qm74	7170	4	significant	significant	JJ
cord-015021-pol2qm74	7170	5	difference	difference	NN
cord-015021-pol2qm74	7170	6	found	find	VBN
cord-015021-pol2qm74	7170	7	between	between	IN
cord-015021-pol2qm74	7170	8	the	the	DT
cord-015021-pol2qm74	7170	9	enteral	enteral	NN
cord-015021-pol2qm74	7170	10	fed	feed	VBN
cord-015021-pol2qm74	7170	11	control	control	NN
cord-015021-pol2qm74	7170	12	and	and	CC
cord-015021-pol2qm74	7170	13	the	the	DT
cord-015021-pol2qm74	7170	14	dipeptide	dipeptide	NN
cord-015021-pol2qm74	7170	15	supplemented	supplement	VBD
cord-015021-pol2qm74	7170	16	animals	animal	NNS
cord-015021-pol2qm74	7170	17	concerning	concern	VBG
cord-015021-pol2qm74	7170	18	intestinal	intestinal	JJ
cord-015021-pol2qm74	7170	19	structure	structure	NN
cord-015021-pol2qm74	7170	20	and	and	CC
cord-015021-pol2qm74	7170	21	absorption	absorption	NN
cord-015021-pol2qm74	7170	22	,	,	,
cord-015021-pol2qm74	7170	23	The	the	DT
cord-015021-pol2qm74	7170	24	enzyme	enzyme	NN
cord-015021-pol2qm74	7170	25	activity	activity	NN
cord-015021-pol2qm74	7170	26	was	be	VBD
cord-015021-pol2qm74	7170	27	significantly	significantly	RB
cord-015021-pol2qm74	7170	28	decreased	decrease	VBN
cord-015021-pol2qm74	7170	29	in	in	IN
cord-015021-pol2qm74	7170	30	the	the	DT
cord-015021-pol2qm74	7170	31	Ala	Ala	NNP
cord-015021-pol2qm74	7170	32	-	-	HYPH
cord-015021-pol2qm74	7170	33	GIn	GIn	NNS
cord-015021-pol2qm74	7170	34	supplemented	supplement	VBD
cord-015021-pol2qm74	7170	35	group	group	NN
cord-015021-pol2qm74	7170	36	compared	compare	VBN
cord-015021-pol2qm74	7170	37	to	to	IN
cord-015021-pol2qm74	7170	38	the	the	DT
cord-015021-pol2qm74	7170	39	enteral	enteral	NN
cord-015021-pol2qm74	7170	40	fed	feed	VBN
cord-015021-pol2qm74	7170	41	control	control	NN
cord-015021-pol2qm74	7170	42	(	(	-LRB-
cord-015021-pol2qm74	7170	43	p<0,01	p<0,01	NN
cord-015021-pol2qm74	7170	44	)	)	-RRB-
cord-015021-pol2qm74	7170	45	.	.	.
cord-015021-pol2qm74	7171	1	In	in	IN
cord-015021-pol2qm74	7171	2	this	this	DT
cord-015021-pol2qm74	7171	3	rat	rat	NN
cord-015021-pol2qm74	7171	4	model	model	NN
cord-015021-pol2qm74	7171	5	supplementation	supplementation	NN
cord-015021-pol2qm74	7171	6	of	of	IN
cord-015021-pol2qm74	7171	7	parentera	parentera	NNP
cord-015021-pol2qm74	7171	8	]	]	-RRB-
cord-015021-pol2qm74	7171	9	nutrition	nutrition	NN
cord-015021-pol2qm74	7171	10	solutions	solution	NNS
cord-015021-pol2qm74	7171	11	with	with	IN
cord-015021-pol2qm74	7171	12	Ala	Ala	NNP
cord-015021-pol2qm74	7171	13	-	-	HYPH
cord-015021-pol2qm74	7171	14	GIn	gin	NN
cord-015021-pol2qm74	7171	15	dipeptide	dipeptide	NN
cord-015021-pol2qm74	7171	16	restores	restore	VBZ
cord-015021-pol2qm74	7171	17	TPN	TPN	NNP
cord-015021-pol2qm74	7171	18	induced	induce	VBD
cord-015021-pol2qm74	7171	19	intestinal	intestinal	JJ
cord-015021-pol2qm74	7171	20	atrophy	atrophy	NN
cord-015021-pol2qm74	7171	21	and	and	CC
cord-015021-pol2qm74	7171	22	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7171	23	.	.	.
cord-015021-pol2qm74	7172	1	Boston	Boston	NNP
cord-015021-pol2qm74	7172	2	.	.	.
cord-015021-pol2qm74	7173	1	~	~	NFP
cord-015021-pol2qm74	7173	2	USA	USA	NNP
cord-015021-pol2qm74	7173	3	Injury	Injury	NNP
cord-015021-pol2qm74	7173	4	,	,	,
cord-015021-pol2qm74	7173	5	infection	infection	NN
cord-015021-pol2qm74	7173	6	and	and	CC
cord-015021-pol2qm74	7173	7	major	major	JJ
cord-015021-pol2qm74	7173	8	o1~'ations	o1~'ation	NNS
cord-015021-pol2qm74	7173	9	s	s	NN
cord-015021-pol2qm74	7173	10	~	~	NFP
cord-015021-pol2qm74	7173	11	nulate	nulate	NN
cord-015021-pol2qm74	7173	12	a	a	DT
cord-015021-pol2qm74	7173	13	variety	variety	NN
cord-015021-pol2qm74	7173	14	of	of	IN
cord-015021-pol2qm74	7173	15	factors	factor	NNS
cord-015021-pol2qm74	7173	16	whi~	whi~	CD
cord-015021-pol2qm74	7173	17	initiate	initiate	VBP
cord-015021-pol2qm74	7173	18	the	the	DT
cord-015021-pol2qm74	7173	19	body	body	NN
cord-015021-pol2qm74	7173	20	's	's	POS
cord-015021-pol2qm74	7173	21	response	response	NN
cord-015021-pol2qm74	7173	22	to	to	IN
cord-015021-pol2qm74	7173	23	th~	th~	NNP
cord-015021-pol2qm74	7173	24	st~	st~	NNP
cord-015021-pol2qm74	7173	25	..	..	.
cord-015021-pol2qm74	7174	1	sses	sses	NNP
cord-015021-pol2qm74	7174	2	.	.	.
cord-015021-pol2qm74	7174	3	'	'	''
cord-015021-pol2qm74	7175	1	i"hese	i"hese	JJ
cord-015021-pol2qm74	7175	2	reactions	reaction	NNS
cord-015021-pol2qm74	7175	3	are	be	VBP
cord-015021-pol2qm74	7175	4	m	m	NNP
cord-015021-pol2qm74	7175	5	~	~	CD
cord-015021-pol2qm74	7175	6	liated	liate	VBN
cord-015021-pol2qm74	7175	7	by	by	IN
cord-015021-pol2qm74	7175	8	a	a	DT
cord-015021-pol2qm74	7175	9	cbmage	cbmage	NN
cord-015021-pol2qm74	7175	10	ia	ia	NNP
cord-015021-pol2qm74	7176	1	the	the	DT
cord-015021-pol2qm74	7176	2	neta'al	neta'al	NNP
cord-015021-pol2qm74	7176	3	hormonal	hormonal	JJ
cord-015021-pol2qm74	7176	4	,	,	,
cord-015021-pol2qm74	7176	5	eaC.ranmEmt	eac.ranmemt	ADD
cord-015021-pol2qm74	7176	6	,	,	,
cord-015021-pol2qm74	7176	7	by	by	IN
cord-015021-pol2qm74	7176	8	the	the	DT
cord-015021-pol2qm74	7176	9	elaboration	elaboration	NN
cord-015021-pol2qm74	7176	10	of	of	IN
cord-015021-pol2qm74	7176	11	eytokines	eytokines	NNP
cord-015021-pol2qm74	7176	12	and	and	CC
cord-015021-pol2qm74	7176	13	tl	tl	NNP
cord-015021-pol2qm74	7176	14	~	~	NNP
cord-015021-pol2qm74	7176	15	ougb	ougb	NNP
cord-015021-pol2qm74	7176	16	the	the	DT
cord-015021-pol2qm74	7176	17	stimu	stimu	NNP
cord-015021-pol2qm74	7176	18	/	/	SYM
cord-015021-pol2qm74	7176	19	ation	ation	NN
cord-015021-pol2qm74	7176	20	of	of	IN
cord-015021-pol2qm74	7176	21	other	other	JJ
cord-015021-pol2qm74	7176	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7176	23	mediators	mediator	NNS
cord-015021-pol2qm74	7176	24	.	.	.
cord-015021-pol2qm74	7177	1	This	this	DT
cord-015021-pol2qm74	7177	2	eatabolio	eatabolio	NN
cord-015021-pol2qm74	7177	3	setting	set	VBG
cord-015021-pol2qm74	7177	4	zesulis	zesulis	NNP
cord-015021-pol2qm74	7177	5	in	in	IN
cord-015021-pol2qm74	7177	6	body	body	NN
cord-015021-pol2qm74	7177	7	protein	protein	NN
cord-015021-pol2qm74	7177	8	loss	loss	NN
cord-015021-pol2qm74	7177	9	,	,	,
cord-015021-pol2qm74	7177	10	which	which	WDT
cord-015021-pol2qm74	7177	11	g	g	NN
cord-015021-pol2qm74	7177	12	-	-	HYPH
cord-015021-pol2qm74	7177	13	taduaI1y	taduaI1y	NNP
cord-015021-pol2qm74	7177	14	erodes	erode	VBZ
cord-015021-pol2qm74	7177	15	both	both	CC
cord-015021-pol2qm74	7177	16	fimetianal	fimetianal	JJ
cord-015021-pol2qm74	7177	17	and	and	CC
cord-015021-pol2qm74	7177	18	stm~	stm~	CD
cord-015021-pol2qm74	7177	19	tissue	tissue	NN
cord-015021-pol2qm74	7177	20	.	.	.
cord-015021-pol2qm74	7178	1	Wiu3_B	Wiu3_B	NNP
cord-015021-pol2qm74	7179	1	the	the	DT
cord-015021-pol2qm74	7179	2	normally	normally	RB
cord-015021-pol2qm74	7179	3	nom'ished	nom'ishe	VBN
cord-015021-pol2qm74	7179	4	individual	individual	NN
cord-015021-pol2qm74	7179	5	can	can	MD
cord-015021-pol2qm74	7179	6	withslzod	withslzod	VB
cord-015021-pol2qm74	7179	7	"	"	``
cord-015021-pol2qm74	7179	8	d~	d~	NNP
cord-015021-pol2qm74	7179	9	response	response	NN
cord-015021-pol2qm74	7179	10	for	for	IN
cord-015021-pol2qm74	7179	11	a	a	DT
cord-015021-pol2qm74	7179	12	brief	brief	JJ
cord-015021-pol2qm74	7179	13	period	period	NN
cord-015021-pol2qm74	7179	14	of	of	IN
cord-015021-pol2qm74	7179	15	time	time	NN
cord-015021-pol2qm74	7179	16	,	,	,
cord-015021-pol2qm74	7179	17	Ircolonged	Ircolonged	NNP
cord-015021-pol2qm74	7179	18	eatabolLsm	eatabolLsm	NNP
cord-015021-pol2qm74	7179	19	L~	L~	NNP
cord-015021-pol2qm74	7179	20	associated	associate	VBD
cord-015021-pol2qm74	7179	21	with	with	IN
cord-015021-pol2qm74	7179	22	~,nmunosuppmssion	~,nmunosuppmssion	NN
cord-015021-pol2qm74	7179	23	,	,	,
cord-015021-pol2qm74	7179	24	poor	poor	JJ
cord-015021-pol2qm74	7179	25	wound	wound	NN
cord-015021-pol2qm74	7179	26	healing	healing	NN
cord-015021-pol2qm74	7179	27	,	,	,
cord-015021-pol2qm74	7179	28	and	and	CC
cord-015021-pol2qm74	7179	29	proioagcd	proioagcd	NN
cord-015021-pol2qm74	7179	30	convalescence	convalescence	NN
cord-015021-pol2qm74	7179	31	.	.	.
cord-015021-pol2qm74	7180	1	Surgeons	surgeon	NNS
cord-015021-pol2qm74	7180	2	have	have	VBP
cord-015021-pol2qm74	7180	3	reJ2ed	rej2ed	NN
cord-015021-pol2qm74	7180	4	on	on	IN
cord-015021-pol2qm74	7180	5	intraveaous	intraveaous	JJ
cord-015021-pol2qm74	7180	6	or	or	CC
cord-015021-pol2qm74	7180	7	eater~	eater~	NNP
cord-015021-pol2qm74	7180	8	feedings	feeding	NNS
cord-015021-pol2qm74	7181	1	to	to	IN
cord-015021-pol2qm74	7181	2	~everse	~everse	NFP
cord-015021-pol2qm74	7181	3	this	this	DT
cord-015021-pol2qm74	7181	4	process	process	NN
cord-015021-pol2qm74	7181	5	.	.	.
cord-015021-pol2qm74	7182	1	A	a	DT
cord-015021-pol2qm74	7182	2	va	va	NNP
cord-015021-pol2qm74	7182	3	~	~	NFP
cord-015021-pol2qm74	7182	4	ety	ety	NNP
cord-015021-pol2qm74	7182	5	of	of	IN
cord-015021-pol2qm74	7182	6	data	datum	NNS
cord-015021-pol2qm74	7182	7	now	now	RB
cord-015021-pol2qm74	7182	8	indicates	indicate	VBZ
cord-015021-pol2qm74	7182	9	that	that	IN
cord-015021-pol2qm74	7182	10	it	-PRON-	PRP
cord-015021-pol2qm74	7182	11	is	be	VBZ
cord-015021-pol2qm74	7182	12	extremely	extremely	RB
cord-015021-pol2qm74	7182	13	di	di	NNP
cord-015021-pol2qm74	7182	14	~	~	NFP
cord-015021-pol2qm74	7182	15	edt	edt	NNP
cord-015021-pol2qm74	7182	16	to	to	IN
cord-015021-pol2qm74	7183	1	replete	replete	JJ
cord-015021-pol2qm74	7183	2	protein	protein	NN
cord-015021-pol2qm74	7183	3	-	-	HYPH
cord-015021-pol2qm74	7183	4	containing	contain	VBG
cord-015021-pol2qm74	7183	5	tissue	tissue	NN
cord-015021-pol2qm74	7183	6	d	d	NN
cord-015021-pol2qm74	7184	1	~g	~g	NFP
cord-015021-pol2qm74	7184	2	the	the	DT
cord-015021-pol2qm74	7184	3	eataholie	eataholie	NNP
cord-015021-pol2qm74	7184	4	state	state	NN
cord-015021-pol2qm74	7184	5	of	of	IN
cord-015021-pol2qm74	7184	6	illness	illness	NN
cord-015021-pol2qm74	7184	7	;	;	:
cord-015021-pol2qm74	7184	8	the	the	DT
cord-015021-pol2qm74	7184	9	umutt	umutt	NNP
cord-015021-pol2qm74	7184	10	response	response	NN
cord-015021-pol2qm74	7184	11	to	to	IN
cord-015021-pol2qm74	7184	12	hypercaloiSe	hypercaloise	CD
cord-015021-pol2qm74	7184	13	feedings	feeding	NNS
cord-015021-pol2qm74	7184	14	in	in	IN
cord-015021-pol2qm74	7184	15	this	this	DT
cord-015021-pol2qm74	7184	16	setting	setting	NN
cord-015021-pol2qm74	7184	17	is	be	VBZ
cord-015021-pol2qm74	7184	18	the	the	DT
cord-015021-pol2qm74	7184	19	incxeased	incxeased	JJ
cord-015021-pol2qm74	7184	20	accretion	accretion	NN
cord-015021-pol2qm74	7184	21	of	of	IN
cord-015021-pol2qm74	7184	22	body	body	NN
cord-015021-pol2qm74	7184	23	fat	fat	NN
cord-015021-pol2qm74	7184	24	md	md	NNP
cord-015021-pol2qm74	7184	25	water	water	NN
cord-015021-pol2qm74	7184	26	.	.	.
cord-015021-pol2qm74	7185	1	Administration	Administration	NNP
cord-015021-pol2qm74	7185	2	of	of	IN
cord-015021-pol2qm74	7185	3	gxow~	gxow~	NNP
cord-015021-pol2qm74	7185	4	ho	ho	NNP
cord-015021-pol2qm74	7186	1	~moae	~moae	NNP
cord-015021-pol2qm74	7187	1	~cesults	~cesults	NNP
cord-015021-pol2qm74	7187	2	i.a	i.a	NNP
cord-015021-pol2qm74	7187	3	n	n	NNP
cord-015021-pol2qm74	7187	4	shift	shift	NN
cord-015021-pol2qm74	7187	5	of	of	IN
cord-015021-pol2qm74	7187	6	the	the	DT
cord-015021-pol2qm74	7187	7	body	body	NN
cord-015021-pol2qm74	7187	8	's	's	POS
cord-015021-pol2qm74	7187	9	oxidative	oxidative	JJ
cord-015021-pol2qm74	7187	10	machinery	machinery	NN
cord-015021-pol2qm74	7187	11	to	to	TO
cord-015021-pol2qm74	7187	12	fat	fat	VB
cord-015021-pol2qm74	7187	13	rather	rather	RB
cord-015021-pol2qm74	7187	14	than	than	IN
cord-015021-pol2qm74	7187	15	eazbohydmte	eazbohydmte	NNP
cord-015021-pol2qm74	7187	16	utiq	utiq	NNP
cord-015021-pol2qm74	7187	17	~	~	NNP
cord-015021-pol2qm74	7187	18	afic~	afic~	NNP
cord-015021-pol2qm74	7187	19	;	;	:
cord-015021-pol2qm74	7187	20	¢oncomitaatiy	¢oncomitaatiy	NNS
cord-015021-pol2qm74	7187	21	,	,	,
cord-015021-pol2qm74	7187	22	protein	protein	NN
cord-015021-pol2qm74	7187	23	synthesis	synthesis	NN
cord-015021-pol2qm74	7187	24	is	be	VBZ
cord-015021-pol2qm74	7187	25	stimulated	stimulate	VBN
cord-015021-pol2qm74	7187	26	.	.	.
cord-015021-pol2qm74	7188	1	This	this	DT
cord-015021-pol2qm74	7188	2	metabolic	metabolic	JJ
cord-015021-pol2qm74	7188	3	state	state	NN
cord-015021-pol2qm74	7188	4	may	may	MD
cord-015021-pol2qm74	7188	5	have	have	VB
cord-015021-pol2qm74	7188	6	clinical	clinical	JJ
cord-015021-pol2qm74	7188	7	utility	utility	NN
cord-015021-pol2qm74	7188	8	in	in	IN
cord-015021-pol2qm74	7188	9	p	p	NN
cord-015021-pol2qm74	7189	1	~e.n.ts	~e.n.ts	NFP
cord-015021-pol2qm74	7189	2	who	who	WP
cord-015021-pol2qm74	7189	3	need	need	VBP
cord-015021-pol2qm74	7189	4	to	to	TO
cord-015021-pol2qm74	7189	5	heal	heal	VB
cord-015021-pol2qm74	7189	6	large	large	JJ
cord-015021-pol2qm74	7189	7	wotmds	wotmds	NN
cord-015021-pol2qm74	7189	8	,	,	,
cord-015021-pol2qm74	7189	9	in	in	IN
cord-015021-pol2qm74	7189	10	those	those	DT
cord-015021-pol2qm74	7189	11	who	who	WP
cord-015021-pol2qm74	7189	12	need	need	VBP
cord-015021-pol2qm74	7189	13	to	to	TO
cord-015021-pol2qm74	7189	14	gain	gain	VB
cord-015021-pol2qm74	7189	15	strength	strength	NN
cord-015021-pol2qm74	7189	16	in	in	IN
cord-015021-pol2qm74	7189	17	order	order	NN
cord-015021-pol2qm74	7189	18	to	to	TO
cord-015021-pol2qm74	7189	19	be	be	VB
cord-015021-pol2qm74	7189	20	w	w	NN
cord-015021-pol2qm74	7189	21	~	~	NFP
cord-015021-pol2qm74	7189	22	ed	ed	NN
cord-015021-pol2qm74	7189	23	5ore	5ore	CD
cord-015021-pol2qm74	7189	24	veatilatory	veatilatory	NN
cord-015021-pol2qm74	7189	25	support	support	NN
cord-015021-pol2qm74	7189	26	,	,	,
cord-015021-pol2qm74	7189	27	or	or	CC
cord-015021-pol2qm74	7189	28	those	those	DT
cord-015021-pol2qm74	7189	29	patients	patient	NNS
cord-015021-pol2qm74	7189	30	who	who	WP
cord-015021-pol2qm74	7190	1	~ve	~ve	NNP
cord-015021-pol2qm74	7191	1	mulfiorgan	mulfiorgan	NNP
cord-015021-pol2qm74	7191	2	failure	failure	NN
cord-015021-pol2qm74	7191	3	and	and	CC
cord-015021-pol2qm74	7191	4	nee~	nee~	NNP
cord-015021-pol2qm74	7191	5	to	to	TO
cord-015021-pol2qm74	7191	6	ealaaace	ealaaace	VB
cord-015021-pol2qm74	7191	7	protein	protein	NN
cord-015021-pol2qm74	7191	8	syatSesis	syatsesis	NN
cord-015021-pol2qm74	7191	9	to	to	IN
cord-015021-pol2qm74	7191	10	in.suze	in.suze	NNP
cord-015021-pol2qm74	7191	11	recovery	recovery	NN
cord-015021-pol2qm74	7191	12	.	.	.
cord-015021-pol2qm74	7192	1	235als	235als	CD
cord-015021-pol2qm74	7192	2	are	be	VBP
cord-015021-pol2qm74	7192	3	now	now	RB
cord-015021-pol2qm74	7192	4	in	in	IN
cord-015021-pol2qm74	7192	5	progress	progress	NN
cord-015021-pol2qm74	7192	6	to	to	IN
cord-015021-pol2qm74	7192	7	dcterm~	dcterm~	NN
cord-015021-pol2qm74	7193	1	e	e	LS
cord-015021-pol2qm74	7193	2	the	the	DT
cord-015021-pol2qm74	7193	3	benefit	benefit	NN
cord-015021-pol2qm74	7193	4	of	of	IN
cord-015021-pol2qm74	7193	5	growth	growth	NN
cord-015021-pol2qm74	7193	6	hormone	hormone	NN
cord-015021-pol2qm74	7193	7	in	in	IN
cord-015021-pol2qm74	7193	8	these	these	DT
cord-015021-pol2qm74	7193	9	and	and	CC
cord-015021-pol2qm74	7193	10	other	other	JJ
cord-015021-pol2qm74	7193	11	disease	disease	NN
cord-015021-pol2qm74	7193	12	state.s	state.s	NN
cord-015021-pol2qm74	7193	13	,	,	,
cord-015021-pol2qm74	7193	14	rn	rn	NN
cord-015021-pol2qm74	7194	1	the	the	DT
cord-015021-pol2qm74	7194	2	fature	fature	NNP
cord-015021-pol2qm74	7194	3	,	,	,
cord-015021-pol2qm74	7194	4	the	the	DT
cord-015021-pol2qm74	7194	5	increased	increase	VBN
cord-015021-pol2qm74	7194	6	use	use	NN
cord-015021-pol2qm74	7194	7	of	of	IN
cord-015021-pol2qm74	7194	8	growth	growth	NN
cord-015021-pol2qm74	7194	9	hormone	hormone	NN
cord-015021-pol2qm74	7194	10	,	,	,
cord-015021-pol2qm74	7194	11	will	will	MD
cord-015021-pol2qm74	7194	12	occur	occur	VB
cord-015021-pol2qm74	7194	13	;	;	:
cord-015021-pol2qm74	7194	14	,	,	,
cord-015021-pol2qm74	7194	15	this	this	DT
cord-015021-pol2qm74	7194	16	and	and	CC
cord-015021-pol2qm74	7194	17	other	other	JJ
cord-015021-pol2qm74	7194	18	growth	growth	NN
cord-015021-pol2qm74	7194	19	factors	factor	NNS
cord-015021-pol2qm74	7194	20	will	will	MD
cord-015021-pol2qm74	7194	21	serve	serve	VB
cord-015021-pol2qm74	7194	22	to	to	IN
cord-015021-pol2qm74	7194	23	su~2po~	su~2po~	NNP
cord-015021-pol2qm74	7194	24	the	the	DT
cord-015021-pol2qm74	7194	25	host	host	NN
cord-015021-pol2qm74	7194	26	and	and	CC
cord-015021-pol2qm74	7194	27	shorten	shorten	VB
cord-015021-pol2qm74	7194	28	convalesceace	convalesceace	NN
cord-015021-pol2qm74	7194	29	following	follow	VBG
cord-015021-pol2qm74	7194	30	catabolic	catabolic	JJ
cord-015021-pol2qm74	7194	31	diseases	disease	NNS
cord-015021-pol2qm74	7194	32	.	.	.
cord-015021-pol2qm74	7195	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	7195	2	objective	objective	NN
cord-015021-pol2qm74	7195	3	was	be	VBD
cord-015021-pol2qm74	7195	4	to	to	TO
cord-015021-pol2qm74	7195	5	study	study	VB
cord-015021-pol2qm74	7195	6	effects	effect	NNS
cord-015021-pol2qm74	7195	7	of	of	IN
cord-015021-pol2qm74	7195	8	pre	pre	JJ
cord-015021-pol2qm74	7195	9	-	-	JJ
cord-015021-pol2qm74	7195	10	trauma	trauma	JJ
cord-015021-pol2qm74	7195	11	growth	growth	NN
cord-015021-pol2qm74	7195	12	hormone	hormone	NN
cord-015021-pol2qm74	7195	13	(	(	-LRB-
cord-015021-pol2qm74	7195	14	GH	gh	NN
cord-015021-pol2qm74	7195	15	)	)	-RRB-
cord-015021-pol2qm74	7195	16	treatment	treatment	NN
cord-015021-pol2qm74	7195	17	on	on	IN
cord-015021-pol2qm74	7195	18	liver	liver	NN
cord-015021-pol2qm74	7195	19	and	and	CC
cord-015021-pol2qm74	7195	20	skeletal	skeletal	JJ
cord-015021-pol2qm74	7195	21	muscle	muscle	NN
cord-015021-pol2qm74	7195	22	metabolism	metabolism	NN
cord-015021-pol2qm74	7195	23	in	in	IN
cord-015021-pol2qm74	7195	24	a	a	DT
cord-015021-pol2qm74	7195	25	trauma	trauma	NN
cord-015021-pol2qm74	7195	26	model	model	NN
cord-015021-pol2qm74	7195	27	in	in	IN
cord-015021-pol2qm74	7195	28	piglets	piglet	NNS
cord-015021-pol2qm74	7195	29	.	.	.
cord-015021-pol2qm74	7196	1	Twenty	twenty	CD
cord-015021-pol2qm74	7196	2	-	-	HYPH
cord-015021-pol2qm74	7196	3	four	four	CD
cord-015021-pol2qm74	7196	4	piglets	piglet	NNS
cord-015021-pol2qm74	7196	5	were	be	VBD
cord-015021-pol2qm74	7196	6	randomized	randomize	VBN
cord-015021-pol2qm74	7196	7	to	to	IN
cord-015021-pol2qm74	7196	8	three	three	CD
cord-015021-pol2qm74	7196	9	treatment	treatment	NN
cord-015021-pol2qm74	7196	10	groups	group	NNS
cord-015021-pol2qm74	7196	11	;	;	:
cord-015021-pol2qm74	7196	12	one	one	CD
cord-015021-pol2qm74	7196	13	group	group	NN
cord-015021-pol2qm74	7196	14	was	be	VBD
cord-015021-pol2qm74	7196	15	pretreated	pretreate	VBN
cord-015021-pol2qm74	7196	16	with	with	IN
cord-015021-pol2qm74	7196	17	GH	GH	NNP
cord-015021-pol2qm74	7196	18	24	24	CD
cord-015021-pol2qm74	7196	19	IU	IU	NNP
cord-015021-pol2qm74	7196	20	daily	daily	RB
cord-015021-pol2qm74	7196	21	three	three	CD
cord-015021-pol2qm74	7196	22	days	day	NNS
cord-015021-pol2qm74	7196	23	before	before	IN
cord-015021-pol2qm74	7196	24	the	the	DT
cord-015021-pol2qm74	7196	25	experiment	experiment	NN
cord-015021-pol2qm74	7196	26	(	(	-LRB-
cord-015021-pol2qm74	7196	27	GH-3	GH-3	NNP
cord-015021-pol2qm74	7196	28	)	)	-RRB-
cord-015021-pol2qm74	7196	29	,	,	,
cord-015021-pol2qm74	7196	30	another	another	DT
cord-015021-pol2qm74	7196	31	group	group	NN
cord-015021-pol2qm74	7196	32	treated	treat	VBN
cord-015021-pol2qm74	7196	33	with	with	IN
cord-015021-pol2qm74	7196	34	GH	GH	NNP
cord-015021-pol2qm74	7196	35	24	24	CD
cord-015021-pol2qm74	7196	36	IE	IE	NNP
cord-015021-pol2qm74	7196	37	at	at	IN
cord-015021-pol2qm74	7196	38	the	the	DT
cord-015021-pol2qm74	7196	39	start	start	NN
cord-015021-pol2qm74	7196	40	of	of	IN
cord-015021-pol2qm74	7196	41	the	the	DT
cord-015021-pol2qm74	7196	42	surgical	surgical	JJ
cord-015021-pol2qm74	7196	43	procedure	procedure	NN
cord-015021-pol2qm74	7196	44	(	(	-LRB-
cord-015021-pol2qm74	7196	45	GH-1	GH-1	NNP
cord-015021-pol2qm74	7196	46	)	)	-RRB-
cord-015021-pol2qm74	7196	47	and	and	CC
cord-015021-pol2qm74	7196	48	one	one	CD
cord-015021-pol2qm74	7196	49	group	group	NN
cord-015021-pol2qm74	7196	50	served	serve	VBD
cord-015021-pol2qm74	7196	51	as	as	IN
cord-015021-pol2qm74	7196	52	untreated	untreated	JJ
cord-015021-pol2qm74	7196	53	controls	control	NNS
cord-015021-pol2qm74	7196	54	(	(	-LRB-
cord-015021-pol2qm74	7196	55	CON	con	NN
cord-015021-pol2qm74	7196	56	)	)	-RRB-
cord-015021-pol2qm74	7196	57	.	.	.
cord-015021-pol2qm74	7197	1	They	-PRON-	PRP
cord-015021-pol2qm74	7197	2	underwent	undergo	VBD
cord-015021-pol2qm74	7197	3	a	a	DT
cord-015021-pol2qm74	7197	4	standardized	standardized	JJ
cord-015021-pol2qm74	7197	5	surgical	surgical	JJ
cord-015021-pol2qm74	7197	6	procedure	procedure	NN
cord-015021-pol2qm74	7197	7	to	to	IN
cord-015021-pol2qm74	7197	8	place	place	VB
cord-015021-pol2qm74	7197	9	sampling	sampling	NN
cord-015021-pol2qm74	7197	10	cathethers	cathether	NNS
cord-015021-pol2qm74	7197	11	in	in	IN
cord-015021-pol2qm74	7197	12	the	the	DT
cord-015021-pol2qm74	7197	13	portal	portal	NN
cord-015021-pol2qm74	7197	14	,	,	,
cord-015021-pol2qm74	7197	15	hepatic	hepatic	JJ
cord-015021-pol2qm74	7197	16	and	and	CC
cord-015021-pol2qm74	7197	17	femoral	femoral	JJ
cord-015021-pol2qm74	7197	18	veins	vein	NNS
cord-015021-pol2qm74	7197	19	and	and	CC
cord-015021-pol2qm74	7197	20	doppler	doppler	NN
cord-015021-pol2qm74	7197	21	flow	flow	NN
cord-015021-pol2qm74	7197	22	probes	probe	NNS
cord-015021-pol2qm74	7197	23	around	around	IN
cord-015021-pol2qm74	7197	24	the	the	DT
cord-015021-pol2qm74	7197	25	portal	portal	JJ
cord-015021-pol2qm74	7197	26	vein	vein	NN
cord-015021-pol2qm74	7197	27	,	,	,
cord-015021-pol2qm74	7197	28	the	the	DT
cord-015021-pol2qm74	7197	29	hepatic	hepatic	JJ
cord-015021-pol2qm74	7197	30	and	and	CC
cord-015021-pol2qm74	7197	31	the	the	DT
cord-015021-pol2qm74	7197	32	femoral	femoral	JJ
cord-015021-pol2qm74	7197	33	arteries	artery	NNS
cord-015021-pol2qm74	7197	34	.	.	.
cord-015021-pol2qm74	7198	1	All	all	DT
cord-015021-pol2qm74	7198	2	pigs	pig	NNS
cord-015021-pol2qm74	7198	3	recieved	recieve	VBD
cord-015021-pol2qm74	7198	4	a	a	DT
cord-015021-pol2qm74	7198	5	primed	prime	VBN
cord-015021-pol2qm74	7198	6	constant	constant	JJ
cord-015021-pol2qm74	7198	7	infusion	infusion	NN
cord-015021-pol2qm74	7198	8	of	of	IN
cord-015021-pol2qm74	7198	9	U-14C	u-14c	NN
cord-015021-pol2qm74	7198	10	-	-	HYPH
cord-015021-pol2qm74	7198	11	glutamine	glutamine	NN
cord-015021-pol2qm74	7198	12	.	.	.
cord-015021-pol2qm74	7199	1	Substrate	substrate	NN
cord-015021-pol2qm74	7199	2	fluxes	flux	NNS
cord-015021-pol2qm74	7199	3	were	be	VBD
cord-015021-pol2qm74	7199	4	measured	measure	VBN
cord-015021-pol2qm74	7199	5	one	one	CD
cord-015021-pol2qm74	7199	6	(	(	-LRB-
cord-015021-pol2qm74	7199	7	lh	lh	NNP
cord-015021-pol2qm74	7199	8	)	)	-RRB-
cord-015021-pol2qm74	7199	9	and	and	CC
cord-015021-pol2qm74	7199	10	five	five	CD
cord-015021-pol2qm74	7199	11	(	(	-LRB-
cord-015021-pol2qm74	7199	12	5b	5b	NN
cord-015021-pol2qm74	7199	13	)	)	-RRB-
cord-015021-pol2qm74	7199	14	hours	hour	NNS
cord-015021-pol2qm74	7199	15	after	after	IN
cord-015021-pol2qm74	7199	16	termination	termination	NN
cord-015021-pol2qm74	7199	17	of	of	IN
cord-015021-pol2qm74	7199	18	the	the	DT
cord-015021-pol2qm74	7199	19	surgery	surgery	NN
cord-015021-pol2qm74	7199	20	.	.	.
cord-015021-pol2qm74	7200	1	Nitrogen	nitrogen	NN
cord-015021-pol2qm74	7200	2	excretion	excretion	NN
cord-015021-pol2qm74	7200	3	was	be	VBD
cord-015021-pol2qm74	7200	4	significantly	significantly	RB
cord-015021-pol2qm74	7200	5	decreased	decrease	VBN
cord-015021-pol2qm74	7200	6	in	in	IN
cord-015021-pol2qm74	7200	7	the	the	DT
cord-015021-pol2qm74	7200	8	GH	GH	NNP
cord-015021-pol2qm74	7200	9	treated	treat	VBD
cord-015021-pol2qm74	7200	10	animals	animal	NNS
cord-015021-pol2qm74	7200	11	(	(	-LRB-
cord-015021-pol2qm74	7201	1	GH-3:30.8	gh-3:30.8	NN
cord-015021-pol2qm74	7201	2	+	+	SYM
cord-015021-pol2qm74	7201	3	4.2	4.2	CD
cord-015021-pol2qm74	7201	4	mg	mg	NNP
cord-015021-pol2qm74	7201	5	/	/	SYM
cord-015021-pol2qm74	7201	6	kg	kg	NNP
cord-015021-pol2qm74	7202	1	,	,	,
cord-015021-pol2qm74	7202	2	GH	GH	NNP
cord-015021-pol2qm74	7202	3	-	-	HYPH
cord-015021-pol2qm74	7202	4	I	I	NNP
cord-015021-pol2qm74	7202	5	:	:	:
cord-015021-pol2qm74	7203	1	37.6+_.5.8	37.6+_.5.8	CD
cord-015021-pol2qm74	7203	2	mg	mg	NNP
cord-015021-pol2qm74	7203	3	/	/	SYM
cord-015021-pol2qm74	7203	4	kg	kg	NNP
cord-015021-pol2qm74	7203	5	,	,	,
cord-015021-pol2qm74	7203	6	CON	con	NN
cord-015021-pol2qm74	7203	7	:	:	:
cord-015021-pol2qm74	7203	8	55.4	55.4	CD
cord-015021-pol2qm74	7203	9	+	+	SYM
cord-015021-pol2qm74	7203	10	-3.1	-3.1	NNP
cord-015021-pol2qm74	7203	11	mg	mg	NNP
cord-015021-pol2qm74	7203	12	/	/	SYM
cord-015021-pol2qm74	7203	13	kg	kg	NNP
cord-015021-pol2qm74	7203	14	,	,	,
cord-015021-pol2qm74	7203	15	p=0.004	p=0.004	NNP
cord-015021-pol2qm74	7203	16	)	)	-RRB-
cord-015021-pol2qm74	7203	17	.	.	.
cord-015021-pol2qm74	7204	1	In	in	IN
cord-015021-pol2qm74	7204	2	the	the	DT
cord-015021-pol2qm74	7204	3	hindieg	hindieg	NN
cord-015021-pol2qm74	7204	4	,	,	,
cord-015021-pol2qm74	7204	5	there	there	EX
cord-015021-pol2qm74	7204	6	was	be	VBD
cord-015021-pol2qm74	7204	7	reduced	reduce	VBN
cord-015021-pol2qm74	7204	8	net	net	JJ
cord-015021-pol2qm74	7204	9	glutamine	glutamine	NN
cord-015021-pol2qm74	7204	10	efflux	efflux	NN
cord-015021-pol2qm74	7204	11	due	due	JJ
cord-015021-pol2qm74	7204	12	to	to	IN
cord-015021-pol2qm74	7204	13	decreased	decrease	VBN
cord-015021-pol2qm74	7204	14	absolute	absolute	JJ
cord-015021-pol2qm74	7204	15	glutamine	glutamine	NN
cord-015021-pol2qm74	7204	16	release	release	NN
cord-015021-pol2qm74	7204	17	(	(	-LRB-
cord-015021-pol2qm74	7204	18	GH-3:0.9	GH-3:0.9	NNS
cord-015021-pol2qm74	7204	19	+	+	SYM
cord-015021-pol2qm74	7204	20	0.8gmol	0.8gmol	.
cord-015021-pol2qm74	7205	1	/min	/min	NFP
cord-015021-pol2qm74	7205	2	at	at	IN
cord-015021-pol2qm74	7205	3	lh	lh	NNP
cord-015021-pol2qm74	7205	4	and	and	CC
cord-015021-pol2qm74	7205	5	-2.4	-2.4	NN
cord-015021-pol2qm74	7205	6	+	+	CC
cord-015021-pol2qm74	7206	1	1.4	1.4	CD
cord-015021-pol2qm74	7206	2	In.tool/rain	in.tool/rain	CD
cord-015021-pol2qm74	7206	3	at	at	IN
cord-015021-pol2qm74	7206	4	5h	5h	CD
cord-015021-pol2qm74	7206	5	,	,	,
cord-015021-pol2qm74	7206	6	GH	GH	NNP
cord-015021-pol2qm74	7206	7	-	-	HYPH
cord-015021-pol2qm74	7206	8	I	I	NNP
cord-015021-pol2qm74	7206	9	:	:	:
cord-015021-pol2qm74	7206	10	-3.4	-3.4	NN
cord-015021-pol2qm74	7206	11	+	+	CC
cord-015021-pol2qm74	7207	1	1.5	1.5	CD
cord-015021-pol2qm74	7207	2	I.tmol/min	I.tmol/min	NNP
cord-015021-pol2qm74	7207	3	at	at	IN
cord-015021-pol2qm74	7207	4	lh	lh	NNP
cord-015021-pol2qm74	7207	5	and	and	CC
cord-015021-pol2qm74	7207	6	-1.4	-1.4	CD
cord-015021-pol2qm74	7207	7	+	+	CD
cord-015021-pol2qm74	7208	1	1.2	1.2	CD
cord-015021-pol2qm74	7208	2	pmol	pmol	NN
cord-015021-pol2qm74	7208	3	/	/	SYM
cord-015021-pol2qm74	7208	4	min	min	NN
cord-015021-pol2qm74	7208	5	at	at	IN
cord-015021-pol2qm74	7208	6	5h	5h	NNP
cord-015021-pol2qm74	7208	7	,	,	,
cord-015021-pol2qm74	7208	8	CON	con	NN
cord-015021-pol2qm74	7208	9	:	:	:
cord-015021-pol2qm74	7208	10	-8.7+_2.8	-8.7+_2.8	.
cord-015021-pol2qm74	7209	1	g	g	NNP
cord-015021-pol2qm74	7209	2	mol	mol	NNP
cord-015021-pol2qm74	7209	3	/	/	SYM
cord-015021-pol2qm74	7209	4	min	min	NN
cord-015021-pol2qm74	7209	5	at	at	IN
cord-015021-pol2qm74	7209	6	lh	lh	NNP
cord-015021-pol2qm74	7209	7	and	and	CC
cord-015021-pol2qm74	7209	8	-11.6	-11.6	CD
cord-015021-pol2qm74	7209	9	+	+	CC
cord-015021-pol2qm74	7210	1	3.4	3.4	CD
cord-015021-pol2qm74	7210	2	/	/	SYM
cord-015021-pol2qm74	7210	3	amol	amol	NNP
cord-015021-pol2qm74	7210	4	/	/	SYM
cord-015021-pol2qm74	7210	5	min	min	NN
cord-015021-pol2qm74	7210	6	at	at	IN
cord-015021-pol2qm74	7210	7	5h	5h	NNP
cord-015021-pol2qm74	7210	8	,	,	,
cord-015021-pol2qm74	7210	9	p=0.005	p=0.005	NNP
cord-015021-pol2qm74	7210	10	,	,	,
cord-015021-pol2qm74	7210	11	p=0.006	p=0.006	NNP
cord-015021-pol2qm74	7210	12	)	)	-RRB-
cord-015021-pol2qm74	7210	13	,	,	,
cord-015021-pol2qm74	7210	14	whereas	whereas	IN
cord-015021-pol2qm74	7210	15	the	the	DT
cord-015021-pol2qm74	7210	16	absolute	absolute	JJ
cord-015021-pol2qm74	7210	17	uptake	uptake	NN
cord-015021-pol2qm74	7210	18	of	of	IN
cord-015021-pol2qm74	7210	19	glutamine	glutamine	NN
cord-015021-pol2qm74	7210	20	in	in	IN
cord-015021-pol2qm74	7210	21	hindleg	hindleg	NNP
cord-015021-pol2qm74	7210	22	was	be	VBD
cord-015021-pol2qm74	7210	23	unchanged	unchanged	JJ
cord-015021-pol2qm74	7210	24	(	(	-LRB-
cord-015021-pol2qm74	7210	25	p=0.84	p=0.84	NNP
cord-015021-pol2qm74	7210	26	)	)	-RRB-
cord-015021-pol2qm74	7210	27	.	.	.
cord-015021-pol2qm74	7211	1	Glucose	glucose	NN
cord-015021-pol2qm74	7211	2	uptake	uptake	NN
cord-015021-pol2qm74	7211	3	in	in	IN
cord-015021-pol2qm74	7211	4	the	the	DT
cord-015021-pol2qm74	7211	5	hindleg	hindleg	NN
cord-015021-pol2qm74	7211	6	was	be	VBD
cord-015021-pol2qm74	7211	7	decreased	decrease	VBN
cord-015021-pol2qm74	7211	8	(	(	-LRB-
cord-015021-pol2qm74	7211	9	p=0.0006	p=0.0006	NNS
cord-015021-pol2qm74	7211	10	)	)	-RRB-
cord-015021-pol2qm74	7211	11	.	.	.
cord-015021-pol2qm74	7212	1	Net	net	JJ
cord-015021-pol2qm74	7212	2	glutamine	glutamine	NN
cord-015021-pol2qm74	7212	3	uptake	uptake	NN
cord-015021-pol2qm74	7212	4	in	in	IN
cord-015021-pol2qm74	7212	5	liver	liver	NN
cord-015021-pol2qm74	7212	6	was	be	VBD
cord-015021-pol2qm74	7212	7	attenuated	attenuate	VBN
cord-015021-pol2qm74	7212	8	(	(	-LRB-
cord-015021-pol2qm74	7212	9	p=0.03	p=0.03	NN
cord-015021-pol2qm74	7212	10	at	at	IN
cord-015021-pol2qm74	7212	11	5h	5h	CD
cord-015021-pol2qm74	7212	12	)	)	-RRB-
cord-015021-pol2qm74	7212	13	,	,	,
cord-015021-pol2qm74	7212	14	whereas	whereas	IN
cord-015021-pol2qm74	7212	15	net	net	JJ
cord-015021-pol2qm74	7212	16	glutamate	glutamate	NN
cord-015021-pol2qm74	7212	17	release	release	NN
cord-015021-pol2qm74	7212	18	from	from	IN
cord-015021-pol2qm74	7212	19	liver	liver	NN
cord-015021-pol2qm74	7212	20	was	be	VBD
cord-015021-pol2qm74	7212	21	increased	increase	VBN
cord-015021-pol2qm74	7212	22	(	(	-LRB-
cord-015021-pol2qm74	7212	23	p=0.005	p=0.005	NNP
cord-015021-pol2qm74	7212	24	)	)	-RRB-
cord-015021-pol2qm74	7212	25	.	.	.
cord-015021-pol2qm74	7213	1	Thus	thus	RB
cord-015021-pol2qm74	7213	2	,	,	,
cord-015021-pol2qm74	7213	3	pre	pre	JJ
cord-015021-pol2qm74	7213	4	-	-	JJ
cord-015021-pol2qm74	7213	5	trauma	trauma	JJ
cord-015021-pol2qm74	7213	6	treatment	treatment	NN
cord-015021-pol2qm74	7213	7	with	with	IN
cord-015021-pol2qm74	7213	8	GH	GH	NNP
cord-015021-pol2qm74	7213	9	improved	improve	VBD
cord-015021-pol2qm74	7213	10	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7213	11	economy	economy	NN
cord-015021-pol2qm74	7213	12	,	,	,
cord-015021-pol2qm74	7213	13	attenuated	attenuated	JJ
cord-015021-pol2qm74	7213	14	net	net	JJ
cord-015021-pol2qm74	7213	15	glutamine	glutamine	NN
cord-015021-pol2qm74	7213	16	loss	loss	NN
cord-015021-pol2qm74	7213	17	from	from	IN
cord-015021-pol2qm74	7213	18	hindieg	hindieg	NNP
cord-015021-pol2qm74	7213	19	due	due	IN
cord-015021-pol2qm74	7213	20	to	to	IN
cord-015021-pol2qm74	7213	21	decreased	decrease	VBN
cord-015021-pol2qm74	7213	22	absolute	absolute	JJ
cord-015021-pol2qm74	7213	23	release	release	NN
cord-015021-pol2qm74	7213	24	,	,	,
cord-015021-pol2qm74	7213	25	and	and	CC
cord-015021-pol2qm74	7213	26	attenuated	attenuated	JJ
cord-015021-pol2qm74	7213	27	hindleg	hindleg	NNP
cord-015021-pol2qm74	7213	28	glucose	glucose	NN
cord-015021-pol2qm74	7213	29	uptake	uptake	NN
cord-015021-pol2qm74	7213	30	.	.	.
cord-015021-pol2qm74	7214	1	Liver	liver	NN
cord-015021-pol2qm74	7214	2	net	net	JJ
cord-015021-pol2qm74	7214	3	glutanaine	glutanaine	NN
cord-015021-pol2qm74	7214	4	uptake	uptake	NN
cord-015021-pol2qm74	7214	5	was	be	VBD
cord-015021-pol2qm74	7214	6	decerased	decerase	VBN
cord-015021-pol2qm74	7214	7	and	and	CC
cord-015021-pol2qm74	7214	8	net	net	JJ
cord-015021-pol2qm74	7214	9	glutamate	glutamate	NN
cord-015021-pol2qm74	7214	10	release	release	NN
cord-015021-pol2qm74	7214	11	increased	increase	VBD
cord-015021-pol2qm74	7214	12	.	.	.
cord-015021-pol2qm74	7215	1	Patients	patient	NNS
cord-015021-pol2qm74	7215	2	with	with	IN
cord-015021-pol2qm74	7215	3	major	major	JJ
cord-015021-pol2qm74	7215	4	abdominal	abdominal	JJ
cord-015021-pol2qm74	7215	5	surgery	surgery	NN
cord-015021-pol2qm74	7215	6	exhibit	exhibit	NN
cord-015021-pol2qm74	7215	7	a	a	DT
cord-015021-pol2qm74	7215	8	considerable	considerable	JJ
cord-015021-pol2qm74	7215	9	catabolic	catabolic	JJ
cord-015021-pol2qm74	7215	10	response	response	NN
cord-015021-pol2qm74	7215	11	with	with	IN
cord-015021-pol2qm74	7215	12	negative	negative	JJ
cord-015021-pol2qm74	7215	13	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7215	14	balance	balance	NN
cord-015021-pol2qm74	7215	15	and	and	CC
cord-015021-pol2qm74	7215	16	protein	protein	NN
cord-015021-pol2qm74	7215	17	breakdown	breakdown	NN
cord-015021-pol2qm74	7215	18	,	,	,
cord-015021-pol2qm74	7215	19	which	which	WDT
cord-015021-pol2qm74	7215	20	may	may	MD
cord-015021-pol2qm74	7215	21	have	have	VB
cord-015021-pol2qm74	7215	22	detrimental	detrimental	JJ
cord-015021-pol2qm74	7215	23	effects	effect	NNS
cord-015021-pol2qm74	7215	24	on	on	IN
cord-015021-pol2qm74	7215	25	outcome	outcome	NN
cord-015021-pol2qm74	7215	26	.	.	.
cord-015021-pol2qm74	7216	1	We	-PRON-	PRP
cord-015021-pol2qm74	7216	2	investigated	investigate	VBD
cord-015021-pol2qm74	7216	3	the	the	DT
cord-015021-pol2qm74	7216	4	effects	effect	NNS
cord-015021-pol2qm74	7216	5	recombinant	recombinant	JJ
cord-015021-pol2qm74	7216	6	human	human	JJ
cord-015021-pol2qm74	7216	7	growth	growth	NN
cord-015021-pol2qm74	7216	8	hormone	hormone	NN
cord-015021-pol2qm74	7216	9	on	on	IN
cord-015021-pol2qm74	7216	10	substrate	substrate	JJ
cord-015021-pol2qm74	7216	11	metabolism	metabolism	NN
cord-015021-pol2qm74	7216	12	in	in	IN
cord-015021-pol2qm74	7216	13	parenterally	parenterally	NN
cord-015021-pol2qm74	7216	14	fed	feed	VBN
cord-015021-pol2qm74	7216	15	patients	patient	NNS
cord-015021-pol2qm74	7216	16	.	.	.
cord-015021-pol2qm74	7217	1	48	48	CD
cord-015021-pol2qm74	7217	2	metabolic	metabolic	JJ
cord-015021-pol2qm74	7217	3	healthy	healthy	JJ
cord-015021-pol2qm74	7217	4	patients	patient	NNS
cord-015021-pol2qm74	7217	5	were	be	VBD
cord-015021-pol2qm74	7217	6	randomized	randomize	VBN
cord-015021-pol2qm74	7217	7	to	to	TO
cord-015021-pol2qm74	7217	8	receive	receive	VB
cord-015021-pol2qm74	7217	9	either	either	CC
cord-015021-pol2qm74	7217	10	placebo	placebo	NN
cord-015021-pol2qm74	7217	11	or	or	CC
cord-015021-pol2qm74	7217	12	HGH	hgh	NN
cord-015021-pol2qm74	7217	13	in	in	IN
cord-015021-pol2qm74	7217	14	a	a	DT
cord-015021-pol2qm74	7217	15	dosage	dosage	NN
cord-015021-pol2qm74	7217	16	of	of	IN
cord-015021-pol2qm74	7217	17	0,075	0,075	CD
cord-015021-pol2qm74	7218	1	;	;	:
cord-015021-pol2qm74	7218	2	0,15	0,15	CD
cord-015021-pol2qm74	7218	3	or	or	CC
cord-015021-pol2qm74	7218	4	0,3	0,3	CD
cord-015021-pol2qm74	7218	5	I.U.	I.U.	NNP
cord-015021-pol2qm74	7218	6	per	per	IN
cord-015021-pol2qm74	7218	7	kg	kg	NNP
cord-015021-pol2qm74	7218	8	BW	BW	NNP
cord-015021-pol2qm74	7218	9	.	.	.
cord-015021-pol2qm74	7219	1	Substrate	substrate	NN
cord-015021-pol2qm74	7219	2	oxidation	oxidation	NN
cord-015021-pol2qm74	7219	3	rate	rate	NN
cord-015021-pol2qm74	7219	4	,	,	,
cord-015021-pol2qm74	7219	5	energy	energy	NN
cord-015021-pol2qm74	7219	6	expenditure	expenditure	NN
cord-015021-pol2qm74	7219	7	as	as	RB
cord-015021-pol2qm74	7219	8	well	well	RB
cord-015021-pol2qm74	7219	9	as	as	IN
cord-015021-pol2qm74	7219	10	short	short	JJ
cord-015021-pol2qm74	7219	11	life	life	NN
cord-015021-pol2qm74	7219	12	proteins	protein	NNS
cord-015021-pol2qm74	7219	13	were	be	VBD
cord-015021-pol2qm74	7219	14	measured	measure	VBN
cord-015021-pol2qm74	7219	15	daily	daily	RB
cord-015021-pol2qm74	7219	16	.	.	.
cord-015021-pol2qm74	7220	1	Six	six	CD
cord-015021-pol2qm74	7220	2	patients	patient	NNS
cord-015021-pol2qm74	7220	3	were	be	VBD
cord-015021-pol2qm74	7220	4	excluded	exclude	VBN
cord-015021-pol2qm74	7220	5	from	from	IN
cord-015021-pol2qm74	7220	6	analysis	analysis	NN
cord-015021-pol2qm74	7220	7	as	as	IN
cord-015021-pol2qm74	7220	8	drop	drop	NN
cord-015021-pol2qm74	7220	9	outs	out	NNS
cord-015021-pol2qm74	7220	10	,	,	,
cord-015021-pol2qm74	7220	11	due	due	IN
cord-015021-pol2qm74	7220	12	to	to	IN
cord-015021-pol2qm74	7220	13	surgical	surgical	JJ
cord-015021-pol2qm74	7220	14	complications	complication	NNS
cord-015021-pol2qm74	7220	15	.	.	.
cord-015021-pol2qm74	7221	1	We	-PRON-	PRP
cord-015021-pol2qm74	7221	2	could	could	MD
cord-015021-pol2qm74	7221	3	find	find	VB
cord-015021-pol2qm74	7221	4	a	a	DT
cord-015021-pol2qm74	7221	5	dose	dose	NN
cord-015021-pol2qm74	7221	6	-	-	HYPH
cord-015021-pol2qm74	7221	7	dependend	dependend	NN
cord-015021-pol2qm74	7221	8	effect	effect	NN
cord-015021-pol2qm74	7221	9	of	of	IN
cord-015021-pol2qm74	7221	10	growth	growth	NN
cord-015021-pol2qm74	7221	11	hormone	hormone	NN
cord-015021-pol2qm74	7221	12	on	on	IN
cord-015021-pol2qm74	7221	13	resting	rest	VBG
cord-015021-pol2qm74	7221	14	energy	energy	NN
cord-015021-pol2qm74	7221	15	expenditure	expenditure	NN
cord-015021-pol2qm74	7221	16	,	,	,
cord-015021-pol2qm74	7221	17	carbohydrate	carbohydrate	NN
cord-015021-pol2qm74	7221	18	oxidation	oxidation	NN
cord-015021-pol2qm74	7221	19	,	,	,
cord-015021-pol2qm74	7221	20	fat	fat	JJ
cord-015021-pol2qm74	7221	21	and	and	CC
cord-015021-pol2qm74	7221	22	proteine	proteine	JJ
cord-015021-pol2qm74	7221	23	oxidation	oxidation	NN
cord-015021-pol2qm74	7221	24	.	.	.
cord-015021-pol2qm74	7222	1	With	with	IN
cord-015021-pol2qm74	7222	2	increasing	increase	VBG
cord-015021-pol2qm74	7222	3	growth	growth	NN
cord-015021-pol2qm74	7222	4	hormone	hormone	NN
cord-015021-pol2qm74	7222	5	resting	rest	VBG
cord-015021-pol2qm74	7222	6	energy	energy	NN
cord-015021-pol2qm74	7222	7	expenditure	expenditure	NN
cord-015021-pol2qm74	7222	8	increased	increase	VBD
cord-015021-pol2qm74	7222	9	from	from	IN
cord-015021-pol2qm74	7222	10	20.9	20.9	CD
cord-015021-pol2qm74	7222	11	calories	calorie	NNS
cord-015021-pol2qm74	7222	12	per	per	IN
cord-015021-pol2qm74	7222	13	kg	kg	NN
cord-015021-pol2qm74	7222	14	body	body	NN
cord-015021-pol2qm74	7222	15	weight	weight	NN
cord-015021-pol2qm74	7222	16	to	to	IN
cord-015021-pol2qm74	7222	17	26.6	26.6	CD
cord-015021-pol2qm74	7222	18	calories	calorie	NNS
cord-015021-pol2qm74	7222	19	.	.	.
cord-015021-pol2qm74	7223	1	This	this	DT
cord-015021-pol2qm74	7223	2	was	be	VBD
cord-015021-pol2qm74	7223	3	mainly	mainly	RB
cord-015021-pol2qm74	7223	4	due	due	JJ
cord-015021-pol2qm74	7223	5	to	to	IN
cord-015021-pol2qm74	7223	6	an	an	DT
cord-015021-pol2qm74	7223	7	increased	increase	VBN
cord-015021-pol2qm74	7223	8	carbohydrate	carbohydrate	NN
cord-015021-pol2qm74	7223	9	and	and	CC
cord-015021-pol2qm74	7223	10	fat	fat	JJ
cord-015021-pol2qm74	7223	11	oxidation	oxidation	NN
cord-015021-pol2qm74	7223	12	,	,	,
cord-015021-pol2qm74	7223	13	while	while	IN
cord-015021-pol2qm74	7223	14	proteine	proteine	NNP
cord-015021-pol2qm74	7223	15	oxidation	oxidation	NN
cord-015021-pol2qm74	7223	16	decreased	decrease	VBD
cord-015021-pol2qm74	7223	17	.	.	.
cord-015021-pol2qm74	7224	1	This	this	DT
cord-015021-pol2qm74	7224	2	was	be	VBD
cord-015021-pol2qm74	7224	3	in	in	IN
cord-015021-pol2qm74	7224	4	accordance	accordance	NN
cord-015021-pol2qm74	7224	5	with	with	IN
cord-015021-pol2qm74	7224	6	a	a	DT
cord-015021-pol2qm74	7224	7	decreased	decrease	VBN
cord-015021-pol2qm74	7224	8	urea.production	urea.production	NN
cord-015021-pol2qm74	7224	9	rate	rate	NN
cord-015021-pol2qm74	7224	10	and	and	CC
cord-015021-pol2qm74	7224	11	an	an	DT
cord-015021-pol2qm74	7224	12	improvement	improvement	NN
cord-015021-pol2qm74	7224	13	in	in	IN
cord-015021-pol2qm74	7224	14	cumulative	cumulative	JJ
cord-015021-pol2qm74	7224	15	nitrogene	nitrogene	JJ
cord-015021-pol2qm74	7224	16	balance	balance	NN
cord-015021-pol2qm74	7224	17	,	,	,
cord-015021-pol2qm74	7224	18	which	which	WDT
cord-015021-pol2qm74	7224	19	increased	increase	VBD
cord-015021-pol2qm74	7224	20	from	from	IN
cord-015021-pol2qm74	7224	21	minus	minus	IN
cord-015021-pol2qm74	7224	22	12.7	12.7	CD
cord-015021-pol2qm74	7224	23	to	to	IN
cord-015021-pol2qm74	7224	24	plus	plus	CC
cord-015021-pol2qm74	7224	25	8.5	8.5	CD
cord-015021-pol2qm74	7224	26	g	g	NN
cord-015021-pol2qm74	7224	27	N	n	CD
cord-015021-pol2qm74	7224	28	/	/	SYM
cord-015021-pol2qm74	7224	29	7	7	CD
cord-015021-pol2qm74	7224	30	days	day	NNS
cord-015021-pol2qm74	7224	31	.	.	.
cord-015021-pol2qm74	7225	1	In	in	IN
cord-015021-pol2qm74	7225	2	consequence	consequence	JJ
cord-015021-pol2qm74	7225	3	short	short	JJ
cord-015021-pol2qm74	7225	4	life	life	NN
cord-015021-pol2qm74	7225	5	proteins	protein	NNS
cord-015021-pol2qm74	7225	6	were	be	VBD
cord-015021-pol2qm74	7225	7	also	also	RB
cord-015021-pol2qm74	7225	8	increased	increase	VBN
cord-015021-pol2qm74	7225	9	.	.	.
cord-015021-pol2qm74	7226	1	The	the	DT
cord-015021-pol2qm74	7226	2	only	only	JJ
cord-015021-pol2qm74	7226	3	negative	negative	JJ
cord-015021-pol2qm74	7226	4	side	side	NN
cord-015021-pol2qm74	7226	5	effect	effect	NN
cord-015021-pol2qm74	7226	6	was	be	VBD
cord-015021-pol2qm74	7226	7	an	an	DT
cord-015021-pol2qm74	7226	8	increased	increase	VBN
cord-015021-pol2qm74	7226	9	blood	blood	NN
cord-015021-pol2qm74	7226	10	glucose	glucose	NN
cord-015021-pol2qm74	7226	11	concentration	concentration	NN
cord-015021-pol2qm74	7226	12	in	in	IN
cord-015021-pol2qm74	7226	13	some	some	DT
cord-015021-pol2qm74	7226	14	of	of	IN
cord-015021-pol2qm74	7226	15	the	the	DT
cord-015021-pol2qm74	7226	16	patients	patient	NNS
cord-015021-pol2qm74	7226	17	,	,	,
cord-015021-pol2qm74	7226	18	making	make	VBG
cord-015021-pol2qm74	7226	19	insuline	insuline	NNP
cord-015021-pol2qm74	7226	20	administration	administration	NN
cord-015021-pol2qm74	7226	21	mandatory	mandatory	JJ
cord-015021-pol2qm74	7226	22	in	in	IN
cord-015021-pol2qm74	7226	23	3	3	CD
cord-015021-pol2qm74	7226	24	patients	patient	NNS
cord-015021-pol2qm74	7226	25	.	.	.
cord-015021-pol2qm74	7227	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	7227	2	results	result	NNS
cord-015021-pol2qm74	7227	3	are	be	VBP
cord-015021-pol2qm74	7227	4	in	in	IN
cord-015021-pol2qm74	7227	5	accordance	accordance	NN
cord-015021-pol2qm74	7227	6	with	with	IN
cord-015021-pol2qm74	7227	7	other	other	JJ
cord-015021-pol2qm74	7227	8	studies	study	NNS
cord-015021-pol2qm74	7227	9	showing	show	VBG
cord-015021-pol2qm74	7227	10	improvement	improvement	NN
cord-015021-pol2qm74	7227	11	of	of	IN
cord-015021-pol2qm74	7227	12	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7227	13	balance	balance	NN
cord-015021-pol2qm74	7227	14	,	,	,
cord-015021-pol2qm74	7227	15	maintainance	maintainance	NN
cord-015021-pol2qm74	7227	16	of	of	IN
cord-015021-pol2qm74	7227	17	lean	lean	JJ
cord-015021-pol2qm74	7227	18	body	body	NN
cord-015021-pol2qm74	7227	19	mass	mass	NN
cord-015021-pol2qm74	7227	20	and	and	CC
cord-015021-pol2qm74	7227	21	muscular	muscular	JJ
cord-015021-pol2qm74	7227	22	strength	strength	NN
cord-015021-pol2qm74	7227	23	.	.	.
cord-015021-pol2qm74	7228	1	If	if	IN
cord-015021-pol2qm74	7228	2	growth	growth	NN
cord-015021-pol2qm74	7228	3	hormone	hormone	NN
cord-015021-pol2qm74	7228	4	administration	administration	NN
cord-015021-pol2qm74	7228	5	may	may	MD
cord-015021-pol2qm74	7228	6	have	have	VB
cord-015021-pol2qm74	7228	7	any	any	DT
cord-015021-pol2qm74	7228	8	impact	impact	NN
cord-015021-pol2qm74	7228	9	on	on	IN
cord-015021-pol2qm74	7228	10	morbidity	morbidity	NN
cord-015021-pol2qm74	7228	11	,	,	,
cord-015021-pol2qm74	7228	12	mortality	mortality	NN
cord-015021-pol2qm74	7228	13	and	and	CC
cord-015021-pol2qm74	7228	14	length	length	NN
cord-015021-pol2qm74	7228	15	of	of	IN
cord-015021-pol2qm74	7228	16	hospital	hospital	NN
cord-015021-pol2qm74	7228	17	stay	stay	NN
cord-015021-pol2qm74	7228	18	in	in	IN
cord-015021-pol2qm74	7228	19	these	these	DT
cord-015021-pol2qm74	7228	20	patients	patient	NNS
cord-015021-pol2qm74	7228	21	it	-PRON-	PRP
cord-015021-pol2qm74	7228	22	should	should	MD
cord-015021-pol2qm74	7228	23	be	be	VB
cord-015021-pol2qm74	7228	24	evaluated	evaluate	VBN
cord-015021-pol2qm74	7228	25	in	in	IN
cord-015021-pol2qm74	7228	26	a	a	DT
cord-015021-pol2qm74	7228	27	larger	large	JJR
cord-015021-pol2qm74	7228	28	number	number	NN
cord-015021-pol2qm74	7228	29	of	of	IN
cord-015021-pol2qm74	7228	30	patients	patient	NNS
cord-015021-pol2qm74	7228	31	.	.	.
cord-015021-pol2qm74	7229	1	In	in	IN
cord-015021-pol2qm74	7229	2	30	30	CD
cord-015021-pol2qm74	7229	3	patient	patient	NN
cord-015021-pol2qm74	7229	4	after	after	IN
cord-015021-pol2qm74	7229	5	liver	liver	NN
cord-015021-pol2qm74	7229	6	transplantation	transplantation	NN
cord-015021-pol2qm74	7229	7	(	(	-LRB-
cord-015021-pol2qm74	7229	8	OLTx	OLTx	NNP
cord-015021-pol2qm74	7229	9	)	)	-RRB-
cord-015021-pol2qm74	7229	10	the	the	DT
cord-015021-pol2qm74	7229	11	effect	effect	NN
cord-015021-pol2qm74	7229	12	of	of	IN
cord-015021-pol2qm74	7229	13	recombinant	recombinant	JJ
cord-015021-pol2qm74	7229	14	human	human	JJ
cord-015021-pol2qm74	7229	15	growth	growth	NN
cord-015021-pol2qm74	7229	16	hormone	hormone	NN
cord-015021-pol2qm74	7229	17	(	(	-LRB-
cord-015021-pol2qm74	7229	18	rhGH	rhGH	NNP
cord-015021-pol2qm74	7229	19	)	)	-RRB-
cord-015021-pol2qm74	7229	20	on	on	IN
cord-015021-pol2qm74	7229	21	protein	protein	NN
cord-015021-pol2qm74	7229	22	metabolism	metabolism	NN
cord-015021-pol2qm74	7229	23	and	and	CC
cord-015021-pol2qm74	7229	24	hormonal	hormonal	JJ
cord-015021-pol2qm74	7229	25	changes	change	NNS
cord-015021-pol2qm74	7229	26	was	be	VBD
cord-015021-pol2qm74	7229	27	studied	study	VBN
cord-015021-pol2qm74	7229	28	.	.	.
cord-015021-pol2qm74	7230	1	Patients	patient	NNS
cord-015021-pol2qm74	7230	2	and	and	CC
cord-015021-pol2qm74	7230	3	methods	method	NNS
cord-015021-pol2qm74	7231	1	:	:	:
cord-015021-pol2qm74	7231	2	the	the	DT
cord-015021-pol2qm74	7231	3	underlying	underlie	VBG
cord-015021-pol2qm74	7231	4	disease	disease	NN
cord-015021-pol2qm74	7231	5	in	in	IN
cord-015021-pol2qm74	7231	6	all	all	DT
cord-015021-pol2qm74	7231	7	patients	patient	NNS
cord-015021-pol2qm74	7231	8	was	be	VBD
cord-015021-pol2qm74	7232	1	end	end	VB
cord-015021-pol2qm74	7232	2	stage	stage	NN
cord-015021-pol2qm74	7232	3	liver	liver	NN
cord-015021-pol2qm74	7232	4	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	7232	5	,	,	,
cord-015021-pol2qm74	7232	6	non	non	JJ
cord-015021-pol2qm74	7232	7	of	of	IN
cord-015021-pol2qm74	7232	8	the	the	DT
cord-015021-pol2qm74	7232	9	patients	patient	NNS
cord-015021-pol2qm74	7232	10	included	include	VBN
cord-015021-pol2qm74	7232	11	in	in	IN
cord-015021-pol2qm74	7232	12	the	the	DT
cord-015021-pol2qm74	7232	13	study	study	NN
cord-015021-pol2qm74	7232	14	was	be	VBD
cord-015021-pol2qm74	7232	15	suffering	suffer	VBG
cord-015021-pol2qm74	7232	16	from	from	IN
cord-015021-pol2qm74	7232	17	malignancies	malignancy	NNS
cord-015021-pol2qm74	7232	18	.	.	.
cord-015021-pol2qm74	7233	1	The	the	DT
cord-015021-pol2qm74	7233	2	patients	patient	NNS
cord-015021-pol2qm74	7233	3	were	be	VBD
cord-015021-pol2qm74	7233	4	randomly	randomly	RB
cord-015021-pol2qm74	7233	5	allocated	allocate	VBN
cord-015021-pol2qm74	7233	6	to	to	TO
cord-015021-pol2qm74	7233	7	receive	receive	VB
cord-015021-pol2qm74	7233	8	either	either	DT
cord-015021-pol2qm74	7233	9	81U	81u	CD
cord-015021-pol2qm74	7233	10	of	of	IN
cord-015021-pol2qm74	7233	11	rhGH	rhGH	NNP
cord-015021-pol2qm74	7233	12	bid	bid	NNP
cord-015021-pol2qm74	7233	13	(	(	-LRB-
cord-015021-pol2qm74	7233	14	sc	sc	NNP
cord-015021-pol2qm74	7233	15	)	)	-RRB-
cord-015021-pol2qm74	7233	16	or	or	CC
cord-015021-pol2qm74	7233	17	no	no	DT
cord-015021-pol2qm74	7233	18	alternative	alternative	JJ
cord-015021-pol2qm74	7233	19	medication	medication	NN
cord-015021-pol2qm74	7233	20	.	.	.
cord-015021-pol2qm74	7234	1	The	the	DT
cord-015021-pol2qm74	7234	2	study	study	NN
cord-015021-pol2qm74	7234	3	period	period	NN
cord-015021-pol2qm74	7234	4	lasted	last	VBD
cord-015021-pol2qm74	7234	5	14	14	CD
cord-015021-pol2qm74	7234	6	days	day	NNS
cord-015021-pol2qm74	7234	7	.	.	.
cord-015021-pol2qm74	7235	1	From	from	IN
cord-015021-pol2qm74	7235	2	daily	daily	JJ
cord-015021-pol2qm74	7235	3	24	24	CD
cord-015021-pol2qm74	7235	4	hrs	hrs	NN
cord-015021-pol2qm74	7235	5	udne	udne	NN
cord-015021-pol2qm74	7235	6	collection	collection	NN
cord-015021-pol2qm74	7235	7	urinary	urinary	JJ
cord-015021-pol2qm74	7235	8	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7235	9	loss	loss	NN
cord-015021-pol2qm74	7235	10	and	and	CC
cord-015021-pol2qm74	7235	11	daily	daily	JJ
cord-015021-pol2qm74	7235	12	loss	loss	NN
cord-015021-pol2qm74	7235	13	of	of	IN
cord-015021-pol2qm74	7235	14	urea	urea	NN
cord-015021-pol2qm74	7235	15	were	be	VBD
cord-015021-pol2qm74	7235	16	determined	determine	VBN
cord-015021-pol2qm74	7235	17	.	.	.
cord-015021-pol2qm74	7236	1	Body	body	NN
cord-015021-pol2qm74	7236	2	compostion	compostion	NN
cord-015021-pol2qm74	7236	3	analysis	analysis	NN
cord-015021-pol2qm74	7236	4	(	(	-LRB-
cord-015021-pol2qm74	7236	5	BCA	BCA	NNP
cord-015021-pol2qm74	7236	6	,	,	,
cord-015021-pol2qm74	7236	7	bioimpedance	bioimpedance	NN
cord-015021-pol2qm74	7236	8	,	,	,
cord-015021-pol2qm74	7236	9	Akern	Akern	NNP
cord-015021-pol2qm74	7236	10	-	-	HYPH
cord-015021-pol2qm74	7236	11	ltaly	ltaly	NNP
cord-015021-pol2qm74	7236	12	)	)	-RRB-
cord-015021-pol2qm74	7236	13	was	be	VBD
cord-015021-pol2qm74	7236	14	performed	perform	VBN
cord-015021-pol2qm74	7236	15	preoperativly	preoperativly	NNP
cord-015021-pol2qm74	7236	16	and	and	CC
cord-015021-pol2qm74	7236	17	at	at	IN
cord-015021-pol2qm74	7236	18	the	the	DT
cord-015021-pol2qm74	7236	19	postoperative	postoperative	JJ
cord-015021-pol2qm74	7236	20	days	day	NNS
cord-015021-pol2qm74	7236	21	7	7	CD
cord-015021-pol2qm74	7236	22	and	and	CC
cord-015021-pol2qm74	7236	23	14	14	CD
cord-015021-pol2qm74	7236	24	to	to	TO
cord-015021-pol2qm74	7236	25	evaluate	evaluate	VB
cord-015021-pol2qm74	7236	26	changes	change	NNS
cord-015021-pol2qm74	7236	27	in	in	IN
cord-015021-pol2qm74	7236	28	body	body	NN
cord-015021-pol2qm74	7236	29	water	water	NN
cord-015021-pol2qm74	7236	30	and	and	CC
cord-015021-pol2qm74	7236	31	body	body	NN
cord-015021-pol2qm74	7236	32	cell	cell	NN
cord-015021-pol2qm74	7236	33	mass	mass	NN
cord-015021-pol2qm74	7236	34	(	(	-LRB-
cord-015021-pol2qm74	7236	35	BCM	BCM	NNP
cord-015021-pol2qm74	7236	36	)	)	-RRB-
cord-015021-pol2qm74	7236	37	.	.	.
cord-015021-pol2qm74	7237	1	The	the	DT
cord-015021-pol2qm74	7237	2	effect	effect	NN
cord-015021-pol2qm74	7237	3	on	on	IN
cord-015021-pol2qm74	7237	4	resting	rest	VBG
cord-015021-pol2qm74	7237	5	energy	energy	NN
cord-015021-pol2qm74	7237	6	expenditure	expenditure	NN
cord-015021-pol2qm74	7237	7	(	(	-LRB-
cord-015021-pol2qm74	7237	8	REE	REE	NNP
cord-015021-pol2qm74	7237	9	)	)	-RRB-
cord-015021-pol2qm74	7237	10	was	be	VBD
cord-015021-pol2qm74	7237	11	analysed	analyse	VBN
cord-015021-pol2qm74	7237	12	using	use	VBG
cord-015021-pol2qm74	7237	13	indirekt	indirekt	NN
cord-015021-pol2qm74	7237	14	calorimetry	calorimetry	NN
cord-015021-pol2qm74	7237	15	wRhin	wRhin	NNP
cord-015021-pol2qm74	7237	16	the	the	DT
cord-015021-pol2qm74	7237	17	same	same	JJ
cord-015021-pol2qm74	7237	18	intervalls	intervall	NNS
cord-015021-pol2qm74	7237	19	(	(	-LRB-
cord-015021-pol2qm74	7237	20	Metabolic	metabolic	JJ
cord-015021-pol2qm74	7237	21	monitor	monitor	NN
cord-015021-pol2qm74	7237	22	,	,	,
cord-015021-pol2qm74	7237	23	Datex	Datex	NNP
cord-015021-pol2qm74	7237	24	)	)	-RRB-
cord-015021-pol2qm74	7237	25	.	.	.
cord-015021-pol2qm74	7238	1	Blood	blood	NN
cord-015021-pol2qm74	7238	2	levels	level	NNS
cord-015021-pol2qm74	7238	3	of	of	IN
cord-015021-pol2qm74	7238	4	GH	GH	NNP
cord-015021-pol2qm74	7238	5	,	,	,
cord-015021-pol2qm74	7238	6	IGF1	IGF1	NNP
cord-015021-pol2qm74	7238	7	and	and	CC
cord-015021-pol2qm74	7238	8	IGF2	IGF2	NNP
cord-015021-pol2qm74	7238	9	,	,	,
cord-015021-pol2qm74	7238	10	IGFBP3	IGFBP3	NNP
cord-015021-pol2qm74	7238	11	were	be	VBD
cord-015021-pol2qm74	7238	12	measured	measure	VBN
cord-015021-pol2qm74	7238	13	daily	daily	RB
cord-015021-pol2qm74	7238	14	during	during	IN
cord-015021-pol2qm74	7238	15	the	the	DT
cord-015021-pol2qm74	7238	16	study	study	NN
cord-015021-pol2qm74	7238	17	period	period	NN
cord-015021-pol2qm74	7238	18	,	,	,
cord-015021-pol2qm74	7238	19	on	on	IN
cord-015021-pol2qm74	7238	20	day	day	NN
cord-015021-pol2qm74	7238	21	3	3	CD
cord-015021-pol2qm74	7238	22	a	a	DT
cord-015021-pol2qm74	7238	23	24	24	CD
cord-015021-pol2qm74	7238	24	hour	hour	NN
cord-015021-pol2qm74	7238	25	profile	profile	NN
cord-015021-pol2qm74	7238	26	of	of	IN
cord-015021-pol2qm74	7238	27	GH	GH	NNP
cord-015021-pol2qm74	7238	28	was.performed	was.performed	NNP
cord-015021-pol2qm74	7238	29	.	.	.
cord-015021-pol2qm74	7238	30	Samples	sample	NNS
cord-015021-pol2qm74	7238	31	were	be	VBD
cord-015021-pol2qm74	7238	32	collected	collect	VBN
cord-015021-pol2qm74	7238	33	each	each	DT
cord-015021-pol2qm74	7238	34	20	20	CD
cord-015021-pol2qm74	7238	35	minutes	minute	NNS
cord-015021-pol2qm74	7238	36	.	.	.
cord-015021-pol2qm74	7239	1	Results	result	NNS
cord-015021-pol2qm74	7239	2	:	:	:
cord-015021-pol2qm74	7240	1	cumulative	cumulative	JJ
cord-015021-pol2qm74	7240	2	udnary	udnary	JJ
cord-015021-pol2qm74	7240	3	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7240	4	and	and	CC
cord-015021-pol2qm74	7240	5	urea	urea	NN
cord-015021-pol2qm74	7240	6	loss	loss	NN
cord-015021-pol2qm74	7240	7	were	be	VBD
cord-015021-pol2qm74	7240	8	not	not	RB
cord-015021-pol2qm74	7240	9	signifcantly	signifcantly	RB
cord-015021-pol2qm74	7240	10	different	different	JJ
cord-015021-pol2qm74	7240	11	for	for	IN
cord-015021-pol2qm74	7240	12	the	the	DT
cord-015021-pol2qm74	7240	13	whole	whole	JJ
cord-015021-pol2qm74	7240	14	study	study	NN
cord-015021-pol2qm74	7240	15	period	period	NN
cord-015021-pol2qm74	7240	16	but	but	CC
cord-015021-pol2qm74	7240	17	for	for	IN
cord-015021-pol2qm74	7240	18	the	the	DT
cord-015021-pol2qm74	7240	19	first	first	JJ
cord-015021-pol2qm74	7240	20	4	4	CD
cord-015021-pol2qm74	7240	21	study	study	NN
cord-015021-pol2qm74	7240	22	days	day	NNS
cord-015021-pol2qm74	7240	23	.	.	.
cord-015021-pol2qm74	7241	1	BIA	BIA	NNP
cord-015021-pol2qm74	7241	2	indicated	indicate	VBD
cord-015021-pol2qm74	7241	3	for	for	IN
cord-015021-pol2qm74	7241	4	the	the	DT
cord-015021-pol2qm74	7241	5	rhGH	rhgh	NN
cord-015021-pol2qm74	7241	6	-	-	HYPH
cord-015021-pol2qm74	7241	7	group	group	NN
cord-015021-pol2qm74	7241	8	a	a	DT
cord-015021-pol2qm74	7241	9	loss	loss	NN
cord-015021-pol2qm74	7241	10	of	of	IN
cord-015021-pol2qm74	7241	11	BCM	bcm	NN
cord-015021-pol2qm74	7241	12	to	to	IN
cord-015021-pol2qm74	7241	13	a	a	DT
cord-015021-pol2qm74	7241	14	lesser	less	JJR
cord-015021-pol2qm74	7241	15	extent	extent	NN
cord-015021-pol2qm74	7241	16	than	than	IN
cord-015021-pol2qm74	7241	17	for	for	IN
cord-015021-pol2qm74	7241	18	the	the	DT
cord-015021-pol2qm74	7241	19	controls	control	NNS
cord-015021-pol2qm74	7241	20	(	(	-LRB-
cord-015021-pol2qm74	7241	21	n.s	n.s	NNP
cord-015021-pol2qm74	7241	22	.	.	NNP
cord-015021-pol2qm74	7241	23	)	)	-RRB-
cord-015021-pol2qm74	7241	24	,	,	,
cord-015021-pol2qm74	7241	25	changes	change	VBZ
cord-015021-pol2qm74	7241	26	in	in	IN
cord-015021-pol2qm74	7241	27	bodywater	bodywater	NNP
cord-015021-pol2qm74	7241	28	where	where	WRB
cord-015021-pol2qm74	7241	29	similar	similar	JJ
cord-015021-pol2qm74	7241	30	for	for	IN
cord-015021-pol2qm74	7241	31	both	both	DT
cord-015021-pol2qm74	7241	32	groups	group	NNS
cord-015021-pol2qm74	7241	33	.	.	.
cord-015021-pol2qm74	7242	1	REE	REE	NNP
cord-015021-pol2qm74	7242	2	changes	change	NNS
cord-015021-pol2qm74	7242	3	(	(	-LRB-
cord-015021-pol2qm74	7242	4	kcal	kcal	NNP
cord-015021-pol2qm74	7242	5	/	/	SYM
cord-015021-pol2qm74	7242	6	kg	kg	NNP
cord-015021-pol2qm74	7242	7	BCM	BCM	NNP
cord-015021-pol2qm74	7242	8	)	)	-RRB-
cord-015021-pol2qm74	7242	9	were	be	VBD
cord-015021-pol2qm74	7242	10	not	not	RB
cord-015021-pol2qm74	7242	11	significantly	significantly	RB
cord-015021-pol2qm74	7242	12	different	different	JJ
cord-015021-pol2qm74	7242	13	for	for	IN
cord-015021-pol2qm74	7242	14	the	the	DT
cord-015021-pol2qm74	7242	15	two	two	CD
cord-015021-pol2qm74	7242	16	groups	group	NNS
cord-015021-pol2qm74	7242	17	.	.	.
cord-015021-pol2qm74	7243	1	Blood	blood	NN
cord-015021-pol2qm74	7243	2	levels	level	NNS
cord-015021-pol2qm74	7243	3	of	of	IN
cord-015021-pol2qm74	7243	4	GH	GH	NNP
cord-015021-pol2qm74	7243	5	and	and	CC
cord-015021-pol2qm74	7243	6	IGF1	IGF1	NNP
cord-015021-pol2qm74	7243	7	differed	differ	VBD
cord-015021-pol2qm74	7243	8	significantly	significantly	RB
cord-015021-pol2qm74	7243	9	between	between	IN
cord-015021-pol2qm74	7243	10	the	the	DT
cord-015021-pol2qm74	7243	11	groups	group	NNS
cord-015021-pol2qm74	7243	12	for	for	IN
cord-015021-pol2qm74	7243	13	the	the	DT
cord-015021-pol2qm74	7243	14	whole	whole	JJ
cord-015021-pol2qm74	7243	15	study	study	NN
cord-015021-pol2qm74	7243	16	period	period	NN
cord-015021-pol2qm74	7243	17	,	,	,
cord-015021-pol2qm74	7243	18	but	but	CC
cord-015021-pol2qm74	7243	19	not	not	RB
cord-015021-pol2qm74	7243	20	IGF2	IGF2	NNP
cord-015021-pol2qm74	7243	21	and	and	CC
cord-015021-pol2qm74	7243	22	IGFBP-3	IGFBP-3	NNP
cord-015021-pol2qm74	7243	23	.	.	.
cord-015021-pol2qm74	7244	1	The	the	DT
cord-015021-pol2qm74	7244	2	circadian	circadian	JJ
cord-015021-pol2qm74	7244	3	rhythm	rhythm	NN
cord-015021-pol2qm74	7244	4	of	of	IN
cord-015021-pol2qm74	7244	5	endogenous	endogenous	JJ
cord-015021-pol2qm74	7244	6	GH	gh	NN
cord-015021-pol2qm74	7244	7	-	-	HYPH
cord-015021-pol2qm74	7244	8	excretion	excretion	NN
cord-015021-pol2qm74	7244	9	had	have	VBD
cord-015021-pol2qm74	7244	10	not	not	RB
cord-015021-pol2qm74	7244	11	been	be	VBN
cord-015021-pol2qm74	7244	12	altered	alter	VBN
cord-015021-pol2qm74	7244	13	by	by	IN
cord-015021-pol2qm74	7244	14	GH	GH	NNP
cord-015021-pol2qm74	7244	15	,	,	,
cord-015021-pol2qm74	7244	16	but	but	CC
cord-015021-pol2qm74	7244	17	absolute	absolute	JJ
cord-015021-pol2qm74	7244	18	levels	level	NNS
cord-015021-pol2qm74	7244	19	of	of	IN
cord-015021-pol2qm74	7244	20	GH	GH	NNP
cord-015021-pol2qm74	7244	21	were	be	VBD
cord-015021-pol2qm74	7244	22	increased	increase	VBN
cord-015021-pol2qm74	7244	23	.	.	.
cord-015021-pol2qm74	7245	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	7245	2	:	:	:
cord-015021-pol2qm74	7245	3	During	during	IN
cord-015021-pol2qm74	7245	4	the	the	DT
cord-015021-pol2qm74	7245	5	first	first	JJ
cord-015021-pol2qm74	7245	6	4	4	CD
cord-015021-pol2qm74	7245	7	days	day	NNS
cord-015021-pol2qm74	7245	8	after	after	IN
cord-015021-pol2qm74	7245	9	OLTx	OLTx	NNS
cord-015021-pol2qm74	7245	10	we	-PRON-	PRP
cord-015021-pol2qm74	7245	11	could	could	MD
cord-015021-pol2qm74	7245	12	proof	proof	VB
cord-015021-pol2qm74	7245	13	the	the	DT
cord-015021-pol2qm74	7245	14	protein	protein	NN
cord-015021-pol2qm74	7245	15	sparing	spare	VBG
cord-015021-pol2qm74	7245	16	effect	effect	NN
cord-015021-pol2qm74	7245	17	of	of	IN
cord-015021-pol2qm74	7245	18	GH	GH	NNP
cord-015021-pol2qm74	7245	19	treatment	treatment	NN
cord-015021-pol2qm74	7245	20	.	.	.
cord-015021-pol2qm74	7246	1	Although	although	IN
cord-015021-pol2qm74	7246	2	the	the	DT
cord-015021-pol2qm74	7246	3	differences	difference	NNS
cord-015021-pol2qm74	7246	4	between	between	IN
cord-015021-pol2qm74	7246	5	the	the	DT
cord-015021-pol2qm74	7246	6	two	two	CD
cord-015021-pol2qm74	7246	7	groups	group	NNS
cord-015021-pol2qm74	7246	8	were	be	VBD
cord-015021-pol2qm74	7246	9	not	not	RB
cord-015021-pol2qm74	7246	10	significantly	significantly	RB
cord-015021-pol2qm74	7246	11	different	different	JJ
cord-015021-pol2qm74	7246	12	for	for	IN
cord-015021-pol2qm74	7246	13	the	the	DT
cord-015021-pol2qm74	7246	14	whole	whole	JJ
cord-015021-pol2qm74	7246	15	study	study	NN
cord-015021-pol2qm74	7246	16	period	period	NN
cord-015021-pol2qm74	7246	17	the	the	DT
cord-015021-pol2qm74	7246	18	results	result	NNS
cord-015021-pol2qm74	7246	19	showed	show	VBD
cord-015021-pol2qm74	7246	20	on	on	IN
cord-015021-pol2qm74	7246	21	all	all	DT
cord-015021-pol2qm74	7246	22	days	day	NNS
cord-015021-pol2qm74	7246	23	a	a	DT
cord-015021-pol2qm74	7246	24	less	less	RBR
cord-015021-pol2qm74	7246	25	catabolic	catabolic	JJ
cord-015021-pol2qm74	7246	26	situation	situation	NN
cord-015021-pol2qm74	7246	27	for	for	IN
cord-015021-pol2qm74	7246	28	the	the	DT
cord-015021-pol2qm74	7246	29	rhGH	rhgh	NN
cord-015021-pol2qm74	7246	30	treated	treat	VBD
cord-015021-pol2qm74	7246	31	patients	patient	NNS
cord-015021-pol2qm74	7246	32	.	.	.
cord-015021-pol2qm74	7247	1	To	to	TO
cord-015021-pol2qm74	7247	2	possibly	possibly	RB
cord-015021-pol2qm74	7247	3	improve	improve	VB
cord-015021-pol2qm74	7247	4	protein	protein	NN
cord-015021-pol2qm74	7247	5	balance	balance	NN
cord-015021-pol2qm74	7247	6	after	after	IN
cord-015021-pol2qm74	7247	7	major	major	JJ
cord-015021-pol2qm74	7247	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	7247	9	surgery	surgery	NN
cord-015021-pol2qm74	7247	10	we	-PRON-	PRP
cord-015021-pol2qm74	7247	11	studied	study	VBD
cord-015021-pol2qm74	7247	12	the	the	DT
cord-015021-pol2qm74	7247	13	effects	effect	NNS
cord-015021-pol2qm74	7247	14	of	of	IN
cord-015021-pol2qm74	7247	15	GH	GH	NNP
cord-015021-pol2qm74	7247	16	on	on	IN
cord-015021-pol2qm74	7247	17	protein	protein	NN
cord-015021-pol2qm74	7247	18	metabolism	metabolism	NN
cord-015021-pol2qm74	7247	19	after	after	IN
cord-015021-pol2qm74	7247	20	LTX	LTX	NNP
cord-015021-pol2qm74	7247	21	.	.	.
cord-015021-pol2qm74	7248	1	Excluding	exclude	VBG
cord-015021-pol2qm74	7248	2	malignant	malignant	JJ
cord-015021-pol2qm74	7248	3	diseases	disease	NNS
cord-015021-pol2qm74	7248	4	,	,	,
cord-015021-pol2qm74	7248	5	29	29	CD
cord-015021-pol2qm74	7248	6	candidates	candidate	NNS
cord-015021-pol2qm74	7248	7	for	for	IN
cord-015021-pol2qm74	7248	8	LTX	LTX	NNP
cord-015021-pol2qm74	7248	9	were	be	VBD
cord-015021-pol2qm74	7248	10	randomized	randomize	VBN
cord-015021-pol2qm74	7248	11	to	to	IN
cord-015021-pol2qm74	7248	12	either	either	DT
cord-015021-pol2qm74	7248	13	postoperatively	postoperatively	RB
cord-015021-pol2qm74	7248	14	receive	receive	VB
cord-015021-pol2qm74	7248	15	the	the	DT
cord-015021-pol2qm74	7248	16	usual	usual	JJ
cord-015021-pol2qm74	7248	17	treatment	treatment	NN
cord-015021-pol2qm74	7248	18	(	(	-LRB-
cord-015021-pol2qm74	7248	19	CO	co	NN
cord-015021-pol2qm74	7248	20	=	=	SYM
cord-015021-pol2qm74	7248	21	control	control	NN
cord-015021-pol2qm74	7248	22	group	group	NN
cord-015021-pol2qm74	7248	23	,	,	,
cord-015021-pol2qm74	7248	24	N=14	N=14	NNP
cord-015021-pol2qm74	7248	25	,	,	,
cord-015021-pol2qm74	7248	26	age	age	NN
cord-015021-pol2qm74	7248	27	range	range	VBP
cord-015021-pol2qm74	7248	28	25	25	CD
cord-015021-pol2qm74	7248	29	-	-	SYM
cord-015021-pol2qm74	7248	30	59	59	CD
cord-015021-pol2qm74	7248	31	yr	yr	NN
cord-015021-pol2qm74	7248	32	,	,	,
cord-015021-pol2qm74	7248	33	BMI	BMI	NNP
cord-015021-pol2qm74	7248	34	23.9	23.9	CD
cord-015021-pol2qm74	7248	35	+	+	CC
cord-015021-pol2qm74	7249	1	5.7	5.7	CD
cord-015021-pol2qm74	7249	2	kg	kg	NNS
cord-015021-pol2qm74	7249	3	/	/	SYM
cord-015021-pol2qm74	7249	4	m	m	NN
cord-015021-pol2qm74	7249	5	2	2	CD
cord-015021-pol2qm74	7249	6	)	)	-RRB-
cord-015021-pol2qm74	7249	7	or	or	CC
cord-015021-pol2qm74	7249	8	for	for	IN
cord-015021-pol2qm74	7249	9	14	14	CD
cord-015021-pol2qm74	7249	10	days	day	NNS
cord-015021-pol2qm74	7249	11	additional	additional	JJ
cord-015021-pol2qm74	7249	12	GH	GH	NNP
cord-015021-pol2qm74	7249	13	(	(	-LRB-
cord-015021-pol2qm74	7249	14	2x8	2x8	CD
cord-015021-pol2qm74	7249	15	I.U.s.c	I.U.s.c	NNP
cord-015021-pol2qm74	7249	16	.	.	.
cord-015021-pol2qm74	7249	17	)	)	-RRB-
cord-015021-pol2qm74	7250	1	(	(	-LRB-
cord-015021-pol2qm74	7250	2	GH	GH	NNP
cord-015021-pol2qm74	7250	3	group	group	NN
cord-015021-pol2qm74	7250	4	,	,	,
cord-015021-pol2qm74	7250	5	N=14	N=14	NNP
cord-015021-pol2qm74	7250	6	,	,	,
cord-015021-pol2qm74	7250	7	21	21	CD
cord-015021-pol2qm74	7250	8	-	-	SYM
cord-015021-pol2qm74	7250	9	59	59	CD
cord-015021-pol2qm74	7250	10	yr	yr	NN
cord-015021-pol2qm74	7250	11	,	,	,
cord-015021-pol2qm74	7250	12	21.8	21.8	CD
cord-015021-pol2qm74	7250	13	+	+	SYM
cord-015021-pol2qm74	7250	14	2.2	2.2	CD
cord-015021-pol2qm74	7250	15	kg	kg	NN
cord-015021-pol2qm74	7250	16	/	/	SYM
cord-015021-pol2qm74	7250	17	m2	m2	NNP
cord-015021-pol2qm74	7250	18	)	)	-RRB-
cord-015021-pol2qm74	7250	19	.	.	.
cord-015021-pol2qm74	7251	1	Metabolic	metabolic	JJ
cord-015021-pol2qm74	7251	2	studies	study	NNS
cord-015021-pol2qm74	7251	3	(	(	-LRB-
cord-015021-pol2qm74	7251	4	calorimetry	calorimetry	NN
cord-015021-pol2qm74	7251	5	and	and	CC
cord-015021-pol2qm74	7251	6	lsC	lsc	JJ
cord-015021-pol2qm74	7251	7	-	-	HYPH
cord-015021-pol2qm74	7251	8	leucine	leucine	NN
cord-015021-pol2qm74	7251	9	infusion	infusion	NN
cord-015021-pol2qm74	7251	10	)	)	-RRB-
cord-015021-pol2qm74	7251	11	were	be	VBD
cord-015021-pol2qm74	7251	12	performed	perform	VBN
cord-015021-pol2qm74	7251	13	5	5	CD
cord-015021-pol2qm74	7251	14	(	(	-LRB-
cord-015021-pol2qm74	7251	15	test	test	VB
cord-015021-pol2qm74	7251	16	A	a	NN
cord-015021-pol2qm74	7251	17	)	)	-RRB-
cord-015021-pol2qm74	7251	18	and	and	CC
cord-015021-pol2qm74	7251	19	11	11	CD
cord-015021-pol2qm74	7251	20	days	day	NNS
cord-015021-pol2qm74	7251	21	(	(	-LRB-
cord-015021-pol2qm74	7251	22	test	test	NN
cord-015021-pol2qm74	7251	23	B	b	NN
cord-015021-pol2qm74	7251	24	)	)	-RRB-
cord-015021-pol2qm74	7251	25	after	after	IN
cord-015021-pol2qm74	7251	26	surgery	surgery	NN
cord-015021-pol2qm74	7251	27	.	.	.
cord-015021-pol2qm74	7252	1	Tracer	tracer	NN
cord-015021-pol2qm74	7252	2	analysis	analysis	NN
cord-015021-pol2qm74	7252	3	was	be	VBD
cord-015021-pol2qm74	7252	4	done	do	VBN
cord-015021-pol2qm74	7252	5	by	by	IN
cord-015021-pol2qm74	7252	6	gas	gas	NN
cord-015021-pol2qm74	7252	7	chromatography	chromatography	NN
cord-015021-pol2qm74	7252	8	-	-	HYPH
cord-015021-pol2qm74	7252	9	mass	mass	NN
cord-015021-pol2qm74	7252	10	spectrometry	spectrometry	NN
cord-015021-pol2qm74	7252	11	.	.	.
cord-015021-pol2qm74	7253	1	During	during	IN
cord-015021-pol2qm74	7253	2	the	the	DT
cord-015021-pol2qm74	7253	3	2-week	2-week	CD
cord-015021-pol2qm74	7253	4	study	study	NN
cord-015021-pol2qm74	7253	5	clinical	clinical	JJ
cord-015021-pol2qm74	7253	6	parameters	parameter	NNS
cord-015021-pol2qm74	7253	7	did	do	VBD
cord-015021-pol2qm74	7253	8	not	not	RB
cord-015021-pol2qm74	7253	9	differ	differ	VB
cord-015021-pol2qm74	7253	10	significantly	significantly	RB
cord-015021-pol2qm74	7253	11	between	between	IN
cord-015021-pol2qm74	7253	12	groups	group	NNS
cord-015021-pol2qm74	7253	13	;	;	:
cord-015021-pol2qm74	7253	14	however	however	RB
cord-015021-pol2qm74	7253	15	,	,	,
cord-015021-pol2qm74	7253	16	there	there	EX
cord-015021-pol2qm74	7253	17	was	be	VBD
cord-015021-pol2qm74	7253	18	a	a	DT
cord-015021-pol2qm74	7253	19	tendency	tendency	NN
cord-015021-pol2qm74	7253	20	for	for	IN
cord-015021-pol2qm74	7253	21	increased	increase	VBN
cord-015021-pol2qm74	7253	22	glucose	glucose	NN
cord-015021-pol2qm74	7253	23	levels	level	NNS
cord-015021-pol2qm74	7253	24	,	,	,
cord-015021-pol2qm74	7253	25	insulin	insulin	NN
cord-015021-pol2qm74	7253	26	need	need	NN
cord-015021-pol2qm74	7253	27	,	,	,
cord-015021-pol2qm74	7253	28	and	and	CC
cord-015021-pol2qm74	7253	29	energy	energy	NN
cord-015021-pol2qm74	7253	30	expenditure	expenditure	NN
cord-015021-pol2qm74	7253	31	at	at	IN
cord-015021-pol2qm74	7253	32	the	the	DT
cord-015021-pol2qm74	7253	33	time	time	NN
cord-015021-pol2qm74	7253	34	of	of	IN
cord-015021-pol2qm74	7253	35	test	test	NN
cord-015021-pol2qm74	7253	36	B	b	NN
cord-015021-pol2qm74	7253	37	in	in	IN
cord-015021-pol2qm74	7253	38	the	the	DT
cord-015021-pol2qm74	7253	39	GH	GH	NNP
cord-015021-pol2qm74	7253	40	group	group	NN
cord-015021-pol2qm74	7253	41	.	.	.
cord-015021-pol2qm74	7254	1	Leucine	leucine	NN
cord-015021-pol2qm74	7254	2	oxidation	oxidation	NN
cord-015021-pol2qm74	7254	3	(	(	-LRB-
cord-015021-pol2qm74	7254	4	X+SE	X+SE	NNP
cord-015021-pol2qm74	7254	5	)	)	-RRB-
cord-015021-pol2qm74	7254	6	during	during	IN
cord-015021-pol2qm74	7254	7	test	test	NN
cord-015021-pol2qm74	7254	8	A;B	a;b	NN
cord-015021-pol2qm74	7254	9	was	be	VBD
cord-015021-pol2qm74	7254	10	117	117	CD
cord-015021-pol2qm74	7254	11	+	+	SYM
cord-015021-pol2qm74	7254	12	10	10	CD
cord-015021-pol2qm74	7254	13	;	;	:
cord-015021-pol2qm74	7254	14	111	111	CD
cord-015021-pol2qm74	7254	15	+	+	SYM
cord-015021-pol2qm74	7254	16	15	15	CD
cord-015021-pol2qm74	7254	17	(	(	-LRB-
cord-015021-pol2qm74	7254	18	CO	CO	NNP
cord-015021-pol2qm74	7254	19	)	)	-RRB-
cord-015021-pol2qm74	7254	20	and	and	CC
cord-015021-pol2qm74	7254	21	110	110	CD
cord-015021-pol2qm74	7254	22	+	+	SYM
cord-015021-pol2qm74	7254	23	7	7	CD
cord-015021-pol2qm74	7254	24	;	;	:
cord-015021-pol2qm74	7254	25	100±12	100±12	CD
cord-015021-pol2qm74	7254	26	(	(	-LRB-
cord-015021-pol2qm74	7254	27	GH	GH	NNP
cord-015021-pol2qm74	7254	28	)	)	-RRB-
cord-015021-pol2qm74	7254	29	pMol	pmol	NN
cord-015021-pol2qm74	7254	30	/	/	SYM
cord-015021-pol2qm74	7254	31	kg	kg	NN
cord-015021-pol2qm74	7254	32	FFM	FFM	NNP
cord-015021-pol2qm74	7254	33	/	/	SYM
cord-015021-pol2qm74	7254	34	h	h	NNP
cord-015021-pol2qm74	7254	35	(	(	-LRB-
cord-015021-pol2qm74	7254	36	n.s	n.s	NNP
cord-015021-pol2qm74	7254	37	.	.	NNP
cord-015021-pol2qm74	7254	38	)	)	-RRB-
cord-015021-pol2qm74	7254	39	.	.	.
cord-015021-pol2qm74	7255	1	Protein	protein	NN
cord-015021-pol2qm74	7255	2	breakdown	breakdown	NN
cord-015021-pol2qm74	7255	3	was	be	VBD
cord-015021-pol2qm74	7255	4	134±16	134±16	CD
cord-015021-pol2qm74	7255	5	;	;	:
cord-015021-pol2qm74	7255	6	131	131	CD
cord-015021-pol2qm74	7255	7	+	+	SYM
cord-015021-pol2qm74	7255	8	30	30	CD
cord-015021-pol2qm74	7255	9	(	(	-LRB-
cord-015021-pol2qm74	7255	10	CO	CO	NNP
cord-015021-pol2qm74	7255	11	)	)	-RRB-
cord-015021-pol2qm74	7255	12	and	and	CC
cord-015021-pol2qm74	7255	13	156	156	CD
cord-015021-pol2qm74	7255	14	+	+	SYM
cord-015021-pol2qm74	7255	15	14	14	CD
cord-015021-pol2qm74	7255	16	;	;	:
cord-015021-pol2qm74	7255	17	178	178	CD
cord-015021-pol2qm74	7255	18	+	+	SYM
cord-015021-pol2qm74	7255	19	30	30	CD
cord-015021-pol2qm74	7256	1	(	(	-LRB-
cord-015021-pol2qm74	7256	2	GH	GH	NNP
cord-015021-pol2qm74	7256	3	)	)	-RRB-
cord-015021-pol2qm74	7256	4	pMol	pmol	NN
cord-015021-pol2qm74	7256	5	/	/	SYM
cord-015021-pol2qm74	7256	6	kg	kg	NN
cord-015021-pol2qm74	7256	7	FFM	FFM	NNP
cord-015021-pol2qm74	7256	8	/	/	SYM
cord-015021-pol2qm74	7256	9	h	h	NNP
cord-015021-pol2qm74	7256	10	(	(	-LRB-
cord-015021-pol2qm74	7256	11	n.s	n.s	NNP
cord-015021-pol2qm74	7256	12	.	.	NNP
cord-015021-pol2qm74	7256	13	)	)	-RRB-
cord-015021-pol2qm74	7256	14	.	.	.
cord-015021-pol2qm74	7257	1	Nonoxidative	nonoxidative	JJ
cord-015021-pol2qm74	7257	2	-	-	HYPH
cord-015021-pol2qm74	7257	3	leuine	leuine	NN
cord-015021-pol2qm74	7257	4	disposal	disposal	NN
cord-015021-pol2qm74	7257	5	was	be	VBD
cord-015021-pol2qm74	7257	6	119±9	119±9	CD
cord-015021-pol2qm74	7257	7	;	;	:
cord-015021-pol2qm74	7257	8	127	127	CD
cord-015021-pol2qm74	7257	9	+	+	SYM
cord-015021-pol2qm74	7257	10	16	16	CD
cord-015021-pol2qm74	7257	11	(	(	-LRB-
cord-015021-pol2qm74	7257	12	CO	CO	NNP
cord-015021-pol2qm74	7257	13	)	)	-RRB-
cord-015021-pol2qm74	7257	14	and	and	CC
cord-015021-pol2qm74	7257	15	139±11	139±11	CD
cord-015021-pol2qm74	7257	16	;	;	:
cord-015021-pol2qm74	7257	17	177	177	CD
cord-015021-pol2qm74	7257	18	+	+	SYM
cord-015021-pol2qm74	7257	19	20	20	CD
cord-015021-pol2qm74	7257	20	(	(	-LRB-
cord-015021-pol2qm74	7257	21	GH	GH	NNP
cord-015021-pol2qm74	7257	22	)	)	-RRB-
cord-015021-pol2qm74	7257	23	pMol	pmol	NN
cord-015021-pol2qm74	7257	24	/	/	SYM
cord-015021-pol2qm74	7257	25	kg	kg	NN
cord-015021-pol2qm74	7257	26	FFM	FFM	NNP
cord-015021-pol2qm74	7257	27	/	/	SYM
cord-015021-pol2qm74	7257	28	h	h	NN
cord-015021-pol2qm74	7257	29	(	(	-LRB-
cord-015021-pol2qm74	7257	30	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	7257	31	for	for	IN
cord-015021-pol2qm74	7257	32	the	the	DT
cord-015021-pol2qm74	7257	33	rise	rise	NN
cord-015021-pol2qm74	7257	34	in	in	IN
cord-015021-pol2qm74	7257	35	the	the	DT
cord-015021-pol2qm74	7257	36	GH	GH	NNP
cord-015021-pol2qm74	7257	37	group	group	NN
cord-015021-pol2qm74	7257	38	)	)	-RRB-
cord-015021-pol2qm74	7257	39	.	.	.
cord-015021-pol2qm74	7258	1	Tracer	tracer	NN
cord-015021-pol2qm74	7258	2	data	datum	NNS
cord-015021-pol2qm74	7258	3	were	be	VBD
cord-015021-pol2qm74	7258	4	supported	support	VBN
cord-015021-pol2qm74	7258	5	by	by	IN
cord-015021-pol2qm74	7258	6	cumulative	cumulative	JJ
cord-015021-pol2qm74	7258	7	urea	urea	NN
cord-015021-pol2qm74	7258	8	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7258	9	excretion	excretion	NN
cord-015021-pol2qm74	7258	10	(	(	-LRB-
cord-015021-pol2qm74	7258	11	days	day	NNS
cord-015021-pol2qm74	7258	12	1	1	CD
cord-015021-pol2qm74	7258	13	-	-	SYM
cord-015021-pol2qm74	7258	14	4	4	CD
cord-015021-pol2qm74	7258	15	:	:	:
cord-015021-pol2qm74	7258	16	GH	GH	NNP
cord-015021-pol2qm74	7258	17	52	52	CD
cord-015021-pol2qm74	7258	18	+	+	SYM
cord-015021-pol2qm74	7258	19	3	3	CD
cord-015021-pol2qm74	7258	20	vs	vs	IN
cord-015021-pol2qm74	7258	21	CO	CO	NNP
cord-015021-pol2qm74	7258	22	66±7	66±7	CD
cord-015021-pol2qm74	7258	23	g	g	NN
cord-015021-pol2qm74	7258	24	;	;	:
cord-015021-pol2qm74	7258	25	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	7258	26	)	)	-RRB-
cord-015021-pol2qm74	7258	27	.	.	.
cord-015021-pol2qm74	7259	1	We	-PRON-	PRP
cord-015021-pol2qm74	7259	2	conclude	conclude	VBP
cord-015021-pol2qm74	7259	3	that	that	IN
cord-015021-pol2qm74	7259	4	after	after	IN
cord-015021-pol2qm74	7259	5	major	major	JJ
cord-015021-pol2qm74	7259	6	abdominal	abdominal	JJ
cord-015021-pol2qm74	7259	7	surgery	surgery	NN
cord-015021-pol2qm74	7259	8	GH	GH	NNP
cord-015021-pol2qm74	7259	9	lowers	lower	VBZ
cord-015021-pol2qm74	7259	10	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7259	11	excretion	excretion	NN
cord-015021-pol2qm74	7259	12	by	by	IN
cord-015021-pol2qm74	7259	13	increasing	increase	VBG
cord-015021-pol2qm74	7259	14	total	total	JJ
cord-015021-pol2qm74	7259	15	body	body	NN
cord-015021-pol2qm74	7259	16	protein	protein	NN
cord-015021-pol2qm74	7259	17	synthesis	synthesis	NN
cord-015021-pol2qm74	7259	18	.	.	.
cord-015021-pol2qm74	7260	1	It	-PRON-	PRP
cord-015021-pol2qm74	7260	2	is	be	VBZ
cord-015021-pol2qm74	7260	3	not	not	RB
cord-015021-pol2qm74	7260	4	known	know	VBN
cord-015021-pol2qm74	7260	5	which	which	WDT
cord-015021-pol2qm74	7260	6	organs	organ	NNS
cord-015021-pol2qm74	7260	7	contribute	contribute	VBP
cord-015021-pol2qm74	7260	8	to	to	IN
cord-015021-pol2qm74	7260	9	this	this	DT
cord-015021-pol2qm74	7260	10	effect	effect	NN
cord-015021-pol2qm74	7260	11	.	.	.
cord-015021-pol2qm74	7261	1	In	in	IN
cord-015021-pol2qm74	7261	2	several	several	JJ
cord-015021-pol2qm74	7261	3	investigations	investigation	NNS
cord-015021-pol2qm74	7261	4	it	-PRON-	PRP
cord-015021-pol2qm74	7261	5	has	have	VBZ
cord-015021-pol2qm74	7261	6	been	be	VBN
cord-015021-pol2qm74	7261	7	shown	show	VBN
cord-015021-pol2qm74	7261	8	that	that	IN
cord-015021-pol2qm74	7261	9	the	the	DT
cord-015021-pol2qm74	7261	10	protein	protein	NN
cord-015021-pol2qm74	7261	11	saving	saving	NN
cord-015021-pol2qm74	7261	12	effect	effect	NN
cord-015021-pol2qm74	7261	13	of	of	IN
cord-015021-pol2qm74	7261	14	recombinant	recombinant	JJ
cord-015021-pol2qm74	7261	15	human	human	JJ
cord-015021-pol2qm74	7261	16	Growth	Growth	NNP
cord-015021-pol2qm74	7261	17	Hormone	Hormone	NNP
cord-015021-pol2qm74	7261	18	(	(	-LRB-
cord-015021-pol2qm74	7261	19	rhGH	rhGH	NNP
cord-015021-pol2qm74	7261	20	)	)	-RRB-
cord-015021-pol2qm74	7261	21	in	in	IN
cord-015021-pol2qm74	7261	22	the	the	DT
cord-015021-pol2qm74	7261	23	postoperative	postoperative	JJ
cord-015021-pol2qm74	7261	24	state	state	NN
cord-015021-pol2qm74	7261	25	is	be	VBZ
cord-015021-pol2qm74	7261	26	accompanied	accompany	VBN
cord-015021-pol2qm74	7261	27	by	by	IN
cord-015021-pol2qm74	7261	28	raised	raise	VBN
cord-015021-pol2qm74	7261	29	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7261	30	levels	level	NNS
cord-015021-pol2qm74	7261	31	in	in	IN
cord-015021-pol2qm74	7261	32	plasma	plasma	NN
cord-015021-pol2qm74	7261	33	.	.	.
cord-015021-pol2qm74	7262	1	It	-PRON-	PRP
cord-015021-pol2qm74	7262	2	was	be	VBD
cord-015021-pol2qm74	7262	3	concluded	conclude	VBN
cord-015021-pol2qm74	7262	4	that	that	IN
cord-015021-pol2qm74	7262	5	the	the	DT
cord-015021-pol2qm74	7262	6	anabolic	anabolic	JJ
cord-015021-pol2qm74	7262	7	effects	effect	NNS
cord-015021-pol2qm74	7262	8	of	of	IN
cord-015021-pol2qm74	7262	9	rhGH	rhgh	NN
cord-015021-pol2qm74	7262	10	were	be	VBD
cord-015021-pol2qm74	7262	11	probably	probably	RB
cord-015021-pol2qm74	7262	12	,	,	,
cord-015021-pol2qm74	7262	13	at	at	IN
cord-015021-pol2qm74	7262	14	least	least	JJS
cord-015021-pol2qm74	7262	15	in	in	IN
cord-015021-pol2qm74	7262	16	part	part	NN
cord-015021-pol2qm74	7262	17	,	,	,
cord-015021-pol2qm74	7262	18	mediated	mediate	VBN
cord-015021-pol2qm74	7262	19	by	by	IN
cord-015021-pol2qm74	7262	20	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7262	21	.	.	.
cord-015021-pol2qm74	7263	1	This	this	DT
cord-015021-pol2qm74	7263	2	study	study	NN
cord-015021-pol2qm74	7263	3	was	be	VBD
cord-015021-pol2qm74	7263	4	aimed	aim	VBN
cord-015021-pol2qm74	7263	5	at	at	IN
cord-015021-pol2qm74	7263	6	detecting	detect	VBG
cord-015021-pol2qm74	7263	7	the	the	DT
cord-015021-pol2qm74	7263	8	efficacy	efficacy	NN
cord-015021-pol2qm74	7263	9	of	of	IN
cord-015021-pol2qm74	7263	10	IGF	IGF	NNP
cord-015021-pol2qm74	7263	11	-	-	:
cord-015021-pol2qm74	7263	12	I	-PRON-	PRP
cord-015021-pol2qm74	7263	13	on	on	IN
cord-015021-pol2qm74	7263	14	modulation	modulation	NN
cord-015021-pol2qm74	7263	15	of	of	IN
cord-015021-pol2qm74	7263	16	the	the	DT
cord-015021-pol2qm74	7263	17	protein	protein	NN
cord-015021-pol2qm74	7263	18	metabolism	metabolism	NN
cord-015021-pol2qm74	7263	19	in	in	IN
cord-015021-pol2qm74	7263	20	the	the	DT
cord-015021-pol2qm74	7263	21	catabolic	catabolic	JJ
cord-015021-pol2qm74	7263	22	state	state	NN
cord-015021-pol2qm74	7263	23	.	.	.
cord-015021-pol2qm74	7264	1	Patients	patient	NNS
cord-015021-pol2qm74	7264	2	and	and	CC
cord-015021-pol2qm74	7264	3	Methodes	Methodes	NNP
cord-015021-pol2qm74	7264	4	:	:	:
cord-015021-pol2qm74	7264	5	38	38	CD
cord-015021-pol2qm74	7264	6	patients	patient	NNS
cord-015021-pol2qm74	7264	7	(	(	-LRB-
cord-015021-pol2qm74	7264	8	both	both	DT
cord-015021-pol2qm74	7264	9	sexes	sex	NNS
cord-015021-pol2qm74	7264	10	,	,	,
cord-015021-pol2qm74	7264	11	age	age	NN
cord-015021-pol2qm74	7264	12	:	:	:
cord-015021-pol2qm74	7264	13	40	40	CD
cord-015021-pol2qm74	7264	14	-	-	SYM
cord-015021-pol2qm74	7264	15	75	75	CD
cord-015021-pol2qm74	7264	16	years	year	NNS
cord-015021-pol2qm74	7264	17	,	,	,
cord-015021-pol2qm74	7264	18	BMI	BMI	NNP
cord-015021-pol2qm74	7264	19	17	17	CD
cord-015021-pol2qm74	7264	20	-	-	SYM
cord-015021-pol2qm74	7264	21	30	30	CD
cord-015021-pol2qm74	7264	22	kg	kg	NN
cord-015021-pol2qm74	7264	23	/	/	SYM
cord-015021-pol2qm74	7264	24	m	m	NN
cord-015021-pol2qm74	7264	25	2	2	CD
cord-015021-pol2qm74	7264	26	)	)	-RRB-
cord-015021-pol2qm74	7264	27	with	with	IN
cord-015021-pol2qm74	7264	28	major	major	JJ
cord-015021-pol2qm74	7264	29	upper	upper	JJ
cord-015021-pol2qm74	7264	30	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	7264	31	surgery	surgery	NN
cord-015021-pol2qm74	7264	32	(	(	-LRB-
cord-015021-pol2qm74	7264	33	gastrectomy	gastrectomy	NN
cord-015021-pol2qm74	7264	34	or	or	CC
cord-015021-pol2qm74	7264	35	partial	partial	JJ
cord-015021-pol2qm74	7264	36	gastrectomy	gastrectomy	NN
cord-015021-pol2qm74	7264	37	)	)	-RRB-
cord-015021-pol2qm74	7264	38	received	receive	VBD
cord-015021-pol2qm74	7264	39	80	80	CD
cord-015021-pol2qm74	7264	40	ug	ug	NNP
cord-015021-pol2qm74	7264	41	rhlGF-1	rhlGF-1	NNP
cord-015021-pol2qm74	7264	42	/	/	SYM
cord-015021-pol2qm74	7264	43	kg	kg	NN
cord-015021-pol2qm74	7264	44	body	body	NN
cord-015021-pol2qm74	7264	45	weight	weight	NN
cord-015021-pol2qm74	7264	46	/	/	SYM
cord-015021-pol2qm74	7264	47	twice	twice	RB
cord-015021-pol2qm74	7264	48	daily	daily	JJ
cord-015021-pol2qm74	7264	49	or	or	CC
cord-015021-pol2qm74	7264	50	placebo	placebo	NN
cord-015021-pol2qm74	7264	51	during	during	IN
cord-015021-pol2qm74	7264	52	5	5	CD
cord-015021-pol2qm74	7264	53	treatment	treatment	NN
cord-015021-pol2qm74	7264	54	days	day	NNS
cord-015021-pol2qm74	7264	55	beginning	begin	VBG
cord-015021-pol2qm74	7264	56	on	on	IN
cord-015021-pol2qm74	7264	57	the	the	DT
cord-015021-pol2qm74	7264	58	first	first	JJ
cord-015021-pol2qm74	7264	59	postoperative	postoperative	JJ
cord-015021-pol2qm74	7264	60	day	day	NN
cord-015021-pol2qm74	7264	61	in	in	IN
cord-015021-pol2qm74	7264	62	a	a	DT
cord-015021-pol2qm74	7264	63	double	double	JJ
cord-015021-pol2qm74	7264	64	-	-	HYPH
cord-015021-pol2qm74	7264	65	blind	blind	JJ
cord-015021-pol2qm74	7264	66	,	,	,
cord-015021-pol2qm74	7264	67	randomized	randomized	JJ
cord-015021-pol2qm74	7264	68	study	study	NN
cord-015021-pol2qm74	7264	69	.	.	.
cord-015021-pol2qm74	7265	1	All	all	DT
cord-015021-pol2qm74	7265	2	patients	patient	NNS
cord-015021-pol2qm74	7265	3	received	receive	VBD
cord-015021-pol2qm74	7265	4	hypocaloric	hypocaloric	JJ
cord-015021-pol2qm74	7265	5	and	and	CC
cord-015021-pol2qm74	7265	6	hyponitrogenous	hyponitrogenous	JJ
cord-015021-pol2qm74	7265	7	total	total	JJ
cord-015021-pol2qm74	7265	8	parenteral	parenteral	JJ
cord-015021-pol2qm74	7265	9	nutrition	nutrition	NN
cord-015021-pol2qm74	7265	10	(	(	-LRB-
cord-015021-pol2qm74	7265	11	3	3	CD
cord-015021-pol2qm74	7265	12	g	g	NN
cord-015021-pol2qm74	7265	13	CHNg	CHNg	NNS
cord-015021-pol2qm74	7265	14	,	,	,
cord-015021-pol2qm74	7265	15	O.6	O.6	NNP
cord-015021-pol2qm74	7265	16	g	g	NNP
cord-015021-pol2qm74	7265	17	AA	AA	NNP
cord-015021-pol2qm74	7265	18	/	/	SYM
cord-015021-pol2qm74	7265	19	kg	kg	NN
cord-015021-pol2qm74	7265	20	)	)	-RRB-
cord-015021-pol2qm74	7266	1	troughout	troughout	NNP
cord-015021-pol2qm74	7266	2	the	the	DT
cord-015021-pol2qm74	7266	3	whole	whole	JJ
cord-015021-pol2qm74	7266	4	study	study	NN
cord-015021-pol2qm74	7266	5	period	period	NN
cord-015021-pol2qm74	7266	6	.	.	.
cord-015021-pol2qm74	7267	1	Cumulated	cumulated	JJ
cord-015021-pol2qm74	7267	2	nitrogen	nitrogen	NN
cord-015021-pol2qm74	7267	3	balance	balance	NN
cord-015021-pol2qm74	7267	4	,	,	,
cord-015021-pol2qm74	7267	5	3-methyl	3-methyl	CD
cord-015021-pol2qm74	7267	6	-	-	HYPH
cord-015021-pol2qm74	7267	7	histidin	histidin	NNP
cord-015021-pol2qm74	7267	8	exretion	exretion	NN
cord-015021-pol2qm74	7267	9	in	in	IN
cord-015021-pol2qm74	7267	10	urine	urine	NN
cord-015021-pol2qm74	7267	11	as	as	RB
cord-015021-pol2qm74	7267	12	well	well	RB
cord-015021-pol2qm74	7267	13	as	as	IN
cord-015021-pol2qm74	7267	14	Serum	serum	NN
cord-015021-pol2qm74	7267	15	-	-	HYPH
cord-015021-pol2qm74	7267	16	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7267	17	levels	level	NNS
cord-015021-pol2qm74	7267	18	have	have	VBP
cord-015021-pol2qm74	7267	19	been	be	VBN
cord-015021-pol2qm74	7267	20	determined	determine	VBN
cord-015021-pol2qm74	7267	21	.	.	.
cord-015021-pol2qm74	7268	1	The	the	DT
cord-015021-pol2qm74	7268	2	two	two	CD
cord-015021-pol2qm74	7268	3	tailed	tailed	JJ
cord-015021-pol2qm74	7268	4	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	7268	5	test	test	NN
cord-015021-pol2qm74	7268	6	was	be	VBD
cord-015021-pol2qm74	7268	7	used	use	VBN
cord-015021-pol2qm74	7268	8	for	for	IN
cord-015021-pol2qm74	7268	9	statistical	statistical	JJ
cord-015021-pol2qm74	7268	10	analysis	analysis	NN
cord-015021-pol2qm74	7268	11	Results	result	NNS
cord-015021-pol2qm74	7268	12	:	:	:
cord-015021-pol2qm74	7268	13	first	first	JJ
cord-015021-pol2qm74	7268	14	results	result	NNS
cord-015021-pol2qm74	7268	15	will	will	MD
cord-015021-pol2qm74	7268	16	be	be	VB
cord-015021-pol2qm74	7268	17	presented	present	VBN
cord-015021-pol2qm74	7269	1	Previous	previous	JJ
cord-015021-pol2qm74	7269	2	studies	study	NNS
cord-015021-pol2qm74	7269	3	have	have	VBP
cord-015021-pol2qm74	7269	4	suggested	suggest	VBN
cord-015021-pol2qm74	7269	5	that	that	IN
cord-015021-pol2qm74	7269	6	growth	growth	NN
cord-015021-pol2qm74	7269	7	hormone	hormone	NN
cord-015021-pol2qm74	7269	8	(	(	-LRB-
cord-015021-pol2qm74	7269	9	GH	GH	NNP
cord-015021-pol2qm74	7269	10	)	)	-RRB-
cord-015021-pol2qm74	7269	11	potentiates	potentiate	VBZ
cord-015021-pol2qm74	7269	12	various	various	JJ
cord-015021-pol2qm74	7269	13	activities	activity	NNS
cord-015021-pol2qm74	7269	14	of	of	IN
cord-015021-pol2qm74	7269	15	leukecytes	leukecyte	NNS
cord-015021-pol2qm74	7269	16	.	.	.
cord-015021-pol2qm74	7270	1	However	however	RB
cord-015021-pol2qm74	7270	2	,	,	,
cord-015021-pol2qm74	7270	3	it	-PRON-	PRP
cord-015021-pol2qm74	7270	4	is	be	VBZ
cord-015021-pol2qm74	7270	5	not	not	RB
cord-015021-pol2qm74	7270	6	clear	clear	JJ
cord-015021-pol2qm74	7270	7	whether	whether	IN
cord-015021-pol2qm74	7270	8	GH	GH	NNP
cord-015021-pol2qm74	7270	9	can	can	MD
cord-015021-pol2qm74	7270	10	improve	improve	VB
cord-015021-pol2qm74	7270	11	survival	survival	NN
cord-015021-pol2qm74	7270	12	of	of	IN
cord-015021-pol2qm74	7270	13	animals	animal	NNS
cord-015021-pol2qm74	7270	14	with	with	IN
cord-015021-pol2qm74	7270	15	gram	gram	JJ
cord-015021-pol2qm74	7270	16	-	-	HYPH
cord-015021-pol2qm74	7270	17	negative	negative	JJ
cord-015021-pol2qm74	7270	18	sepsis	sepsis	NN
cord-015021-pol2qm74	7270	19	.	.	.
cord-015021-pol2qm74	7271	1	We	-PRON-	PRP
cord-015021-pol2qm74	7271	2	investigated	investigate	VBD
cord-015021-pol2qm74	7271	3	the	the	DT
cord-015021-pol2qm74	7271	4	effects	effect	NNS
cord-015021-pol2qm74	7271	5	of	of	IN
cord-015021-pol2qm74	7271	6	GH	GH	NNP
cord-015021-pol2qm74	7271	7	on	on	IN
cord-015021-pol2qm74	7271	8	host	host	NN
cord-015021-pol2qm74	7271	9	response	response	NN
cord-015021-pol2qm74	7271	10	to	to	IN
cord-015021-pol2qm74	7271	11	infection	infection	NN
cord-015021-pol2qm74	7271	12	in	in	IN
cord-015021-pol2qm74	7271	13	septic	septic	JJ
cord-015021-pol2qm74	7271	14	mice	mice	NN
cord-015021-pol2qm74	7271	15	model	model	NN
cord-015021-pol2qm74	7271	16	.	.	.
cord-015021-pol2qm74	7272	1	METHODS	methods	NN
cord-015021-pol2qm74	7273	1	BALB]c	BALB]c	NNP
cord-015021-pol2qm74	7273	2	mice	mouse	NNS
cord-015021-pol2qm74	7273	3	were	be	VBD
cord-015021-pol2qm74	7273	4	randomized	randomize	VBN
cord-015021-pol2qm74	7273	5	to	to	IN
cord-015021-pol2qm74	7273	6	3	3	CD
cord-015021-pol2qm74	7273	7	groups	group	NNS
cord-015021-pol2qm74	7273	8	(	(	-LRB-
cord-015021-pol2qm74	7273	9	n=10	n=10	NNP
cord-015021-pol2qm74	7273	10	/	/	SYM
cord-015021-pol2qm74	7273	11	gronp	gronp	NNP
cord-015021-pol2qm74	7273	12	)	)	-RRB-
cord-015021-pol2qm74	7273	13	:	:	:
cord-015021-pol2qm74	7273	14	GH	gh	NN
cord-015021-pol2qm74	7273	15	-	-	HYPH
cord-015021-pol2qm74	7273	16	high	high	NN
cord-015021-pol2qm74	7273	17	(	(	-LRB-
cord-015021-pol2qm74	7273	18	4	4	CD
cord-015021-pol2qm74	7273	19	+	+	SYM
cord-015021-pol2qm74	7273	20	8mg	8mg	NNP
cord-015021-pol2qm74	7273	21	/	/	SYM
cord-015021-pol2qm74	7273	22	kg	kg	NN
cord-015021-pol2qm74	7273	23	/	/	SYM
cord-015021-pol2qm74	7273	24	day	day	NN
cord-015021-pol2qm74	7273	25	)	)	-RRB-
cord-015021-pol2qm74	7273	26	,	,	,
cord-015021-pol2qm74	7273	27	GH	GH	NNP
cord-015021-pol2qm74	7273	28	-	-	HYPH
cord-015021-pol2qm74	7273	29	Iow	Iow	NNP
cord-015021-pol2qm74	7273	30	(	(	-LRB-
cord-015021-pol2qm74	7273	31	0A8mg	0a8mg	CD
cord-015021-pol2qm74	7273	32	/	/	SYM
cord-015021-pol2qm74	7273	33	kg	kg	NN
cord-015021-pol2qm74	7273	34	/	/	SYM
cord-015021-pol2qm74	7273	35	day	day	NN
cord-015021-pol2qm74	7273	36	)	)	-RRB-
cord-015021-pol2qm74	7273	37	or	or	CC
cord-015021-pol2qm74	7273	38	control	control	NN
cord-015021-pol2qm74	7273	39	(	(	-LRB-
cord-015021-pol2qm74	7273	40	saline	saline	NN
cord-015021-pol2qm74	7273	41	)	)	-RRB-
cord-015021-pol2qm74	7273	42	.	.	.
cord-015021-pol2qm74	7274	1	Following	follow	VBG
cord-015021-pol2qm74	7274	2	subcutaneous	subcutaneous	JJ
cord-015021-pol2qm74	7274	3	treatment	treatment	NN
cord-015021-pol2qm74	7274	4	(	(	-LRB-
cord-015021-pol2qm74	7274	5	every	every	DT
cord-015021-pol2qm74	7274	6	8	8	CD
cord-015021-pol2qm74	7274	7	hours	hour	NNS
cord-015021-pol2qm74	7274	8	for	for	IN
cord-015021-pol2qm74	7274	9	6	6	CD
cord-015021-pol2qm74	7274	10	days	day	NNS
cord-015021-pol2qm74	7274	11	)	)	-RRB-
cord-015021-pol2qm74	7274	12	with	with	IN
cord-015021-pol2qm74	7274	13	GH	GH	NNP
cord-015021-pol2qm74	7274	14	or	or	CC
cord-015021-pol2qm74	7274	15	saline	saline	NN
cord-015021-pol2qm74	7274	16	,	,	,
cord-015021-pol2qm74	7274	17	mice	mouse	NNS
cord-015021-pol2qm74	7274	18	were	be	VBD
cord-015021-pol2qm74	7274	19	challenged	challenge	VBN
cord-015021-pol2qm74	7274	20	i.p	i.p	NNP
cord-015021-pol2qm74	7274	21	.	.	.
cord-015021-pol2qm74	7275	1	with	with	IN
cord-015021-pol2qm74	7275	2	E.coli	E.coli	NNS
cord-015021-pol2qm74	7275	3	(	(	-LRB-
cord-015021-pol2qm74	7275	4	lxl08	lxl08	CD
cord-015021-pol2qm74	7275	5	/	/	SYM
cord-015021-pol2qm74	7275	6	body	body	NN
cord-015021-pol2qm74	7275	7	)	)	-RRB-
cord-015021-pol2qm74	7275	8	.	.	.
cord-015021-pol2qm74	7276	1	Survival	survival	NN
cord-015021-pol2qm74	7276	2	rate	rate	NN
cord-015021-pol2qm74	7276	3	was	be	VBD
cord-015021-pol2qm74	7276	4	recorded	record	VBN
cord-015021-pol2qm74	7276	5	every	every	DT
cord-015021-pol2qm74	7276	6	2	2	CD
cord-015021-pol2qm74	7276	7	hours	hour	NNS
cord-015021-pol2qm74	7276	8	.	.	.
cord-015021-pol2qm74	7277	1	In	in	IN
cord-015021-pol2qm74	7277	2	the	the	DT
cord-015021-pol2qm74	7277	3	next	next	JJ
cord-015021-pol2qm74	7277	4	experiment	experiment	NN
cord-015021-pol2qm74	7277	5	,	,	,
cord-015021-pol2qm74	7277	6	GH	gh	NN
cord-015021-pol2qm74	7277	7	-	-	HYPH
cord-015021-pol2qm74	7277	8	high	high	JJ
cord-015021-pol2qm74	7277	9	and	and	CC
cord-015021-pol2qm74	7277	10	control	control	NN
cord-015021-pol2qm74	7277	11	animals	animal	NNS
cord-015021-pol2qm74	7277	12	were	be	VBD
cord-015021-pol2qm74	7277	13	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	7277	14	4	4	CD
cord-015021-pol2qm74	7277	15	hours	hour	NNS
cord-015021-pol2qm74	7277	16	after	after	IN
cord-015021-pol2qm74	7277	17	bacterial	bacterial	JJ
cord-015021-pol2qm74	7277	18	challenge	challenge	NN
cord-015021-pol2qm74	7277	19	.	.	.
cord-015021-pol2qm74	7278	1	Peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7278	2	cavity	cavity	NN
cord-015021-pol2qm74	7278	3	was	be	VBD
cord-015021-pol2qm74	7278	4	lavaged	lavage	VBN
cord-015021-pol2qm74	7278	5	with	with	IN
cord-015021-pol2qm74	7278	6	3ml	3ml	NN
cord-015021-pol2qm74	7278	7	saline	saline	NN
cord-015021-pol2qm74	7278	8	and	and	CC
cord-015021-pol2qm74	7278	9	the	the	DT
cord-015021-pol2qm74	7278	10	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7278	11	exudative	exudative	JJ
cord-015021-pol2qm74	7278	12	cells	cell	NNS
cord-015021-pol2qm74	7278	13	(	(	-LRB-
cord-015021-pol2qm74	7278	14	PEC	PEC	NNP
cord-015021-pol2qm74	7278	15	)	)	-RRB-
cord-015021-pol2qm74	7278	16	were	be	VBD
cord-015021-pol2qm74	7278	17	harvested	harvest	VBN
cord-015021-pol2qm74	7278	18	and	and	CC
cord-015021-pol2qm74	7278	19	counted	count	VBN
cord-015021-pol2qm74	7278	20	.	.	.
cord-015021-pol2qm74	7279	1	Colony	colony	NN
cord-015021-pol2qm74	7279	2	forming	form	VBG
cord-015021-pol2qm74	7279	3	units	unit	NNS
cord-015021-pol2qm74	7279	4	(	(	-LRB-
cord-015021-pol2qm74	7279	5	CFU	CFU	NNP
cord-015021-pol2qm74	7279	6	)	)	-RRB-
cord-015021-pol2qm74	7279	7	of	of	IN
cord-015021-pol2qm74	7279	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	7279	9	in	in	IN
cord-015021-pol2qm74	7279	10	the	the	DT
cord-015021-pol2qm74	7279	11	peritoneal	peritoneal	NN
cord-015021-pol2qm74	7279	12	lavaged	lavaged	NN
cord-015021-pol2qm74	7279	13	fluid	fluid	NN
cord-015021-pol2qm74	7279	14	(	(	-LRB-
cord-015021-pol2qm74	7279	15	PLF	PLF	NNP
cord-015021-pol2qm74	7279	16	)	)	-RRB-
cord-015021-pol2qm74	7279	17	,	,	,
cord-015021-pol2qm74	7279	18	liver	liver	NN
cord-015021-pol2qm74	7279	19	,	,	,
cord-015021-pol2qm74	7279	20	lung	lung	NN
cord-015021-pol2qm74	7279	21	and	and	CC
cord-015021-pol2qm74	7279	22	blood	blood	NN
cord-015021-pol2qm74	7279	23	were	be	VBD
cord-015021-pol2qm74	7279	24	determined	determine	VBN
cord-015021-pol2qm74	7279	25	.	.	.
cord-015021-pol2qm74	7280	1	PEC	PEC	NNP
cord-015021-pol2qm74	7280	2	were	be	VBD
cord-015021-pol2qm74	7280	3	cultured	culture	VBN
cord-015021-pol2qm74	7280	4	in	in	IN
cord-015021-pol2qm74	7280	5	vitro	vitro	FW
cord-015021-pol2qm74	7280	6	for	for	IN
cord-015021-pol2qm74	7280	7	24	24	CD
cord-015021-pol2qm74	7280	8	hours	hour	NNS
cord-015021-pol2qm74	7280	9	with	with	IN
cord-015021-pol2qm74	7280	10	lipopolymccharide	lipopolymccharide	NNP
cord-015021-pol2qm74	7280	11	(	(	-LRB-
cord-015021-pol2qm74	7280	12	10p.g	10p.g	CD
cord-015021-pol2qm74	7280	13	/	/	SYM
cord-015021-pol2qm74	7280	14	ml	ml	NN
cord-015021-pol2qm74	7281	1	In	in	IN
cord-015021-pol2qm74	7281	2	normotensive	normotensive	JJ
cord-015021-pol2qm74	7281	3	adults	adult	NNS
cord-015021-pol2qm74	7281	4	growth	growth	NN
cord-015021-pol2qm74	7281	5	hormone	hormone	NN
cord-015021-pol2qm74	7281	6	(	(	-LRB-
cord-015021-pol2qm74	7281	7	GH	gh	NN
cord-015021-pol2qm74	7281	8	)	)	-RRB-
cord-015021-pol2qm74	7281	9	rises	rise	VBZ
cord-015021-pol2qm74	7281	10	when	when	WRB
cord-015021-pol2qm74	7281	11	clonidine	clonidine	NN
cord-015021-pol2qm74	7281	12	challenge	challenge	NN
cord-015021-pol2qm74	7281	13	is	be	VBZ
cord-015021-pol2qm74	7281	14	performed	perform	VBN
cord-015021-pol2qm74	7281	15	.	.	.
cord-015021-pol2qm74	7282	1	Recently	recently	RB
cord-015021-pol2qm74	7282	2	evidence	evidence	NN
cord-015021-pol2qm74	7282	3	was	be	VBD
cord-015021-pol2qm74	7282	4	shown	show	VBN
cord-015021-pol2qm74	7282	5	for	for	IN
cord-015021-pol2qm74	7282	6	GH	GH	NNP
cord-015021-pol2qm74	7282	7	to	to	TO
cord-015021-pol2qm74	7282	8	accelerate	accelerate	VB
cord-015021-pol2qm74	7282	9	wound	wind	VBN
cord-015021-pol2qm74	7282	10	healing	healing	NN
cord-015021-pol2qm74	7282	11	.	.	.
cord-015021-pol2qm74	7283	1	While	while	IN
cord-015021-pol2qm74	7283	2	GH	gh	NN
cord-015021-pol2qm74	7283	3	secretion	secretion	NN
cord-015021-pol2qm74	7283	4	patterns	pattern	NNS
cord-015021-pol2qm74	7283	5	are	be	VBP
cord-015021-pol2qm74	7283	6	inconstant	inconstant	JJ
cord-015021-pol2qm74	7283	7	the	the	DT
cord-015021-pol2qm74	7283	8	GH	gh	NN
cord-015021-pol2qm74	7283	9	-	-	HYPH
cord-015021-pol2qm74	7283	10	dependant	dependant	JJ
cord-015021-pol2qm74	7283	11	insulin	insulin	NN
cord-015021-pol2qm74	7283	12	like	like	IN
cord-015021-pol2qm74	7283	13	growth	growth	NN
cord-015021-pol2qm74	7283	14	factor	factor	NN
cord-015021-pol2qm74	7283	15	(	(	-LRB-
cord-015021-pol2qm74	7283	16	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7283	17	)	)	-RRB-
cord-015021-pol2qm74	7283	18	and	and	CC
cord-015021-pol2qm74	7283	19	the	the	DT
cord-015021-pol2qm74	7283	20	insulin	insulin	NN
cord-015021-pol2qm74	7283	21	like	like	IN
cord-015021-pol2qm74	7283	22	growth	growth	NN
cord-015021-pol2qm74	7283	23	factor	factor	NN
cord-015021-pol2qm74	7283	24	binding	bind	VBG
cord-015021-pol2qm74	7283	25	protein	protein	NN
cord-015021-pol2qm74	7283	26	(	(	-LRB-
cord-015021-pol2qm74	7283	27	IGFBP-3	igfbp-3	NN
cord-015021-pol2qm74	7283	28	)	)	-RRB-
cord-015021-pol2qm74	7283	29	reflect	reflect	VB
cord-015021-pol2qm74	7283	30	the	the	DT
cord-015021-pol2qm74	7283	31	integrated	integrated	JJ
cord-015021-pol2qm74	7283	32	GH	GH	NNP
cord-015021-pol2qm74	7283	33	secretion	secretion	NN
cord-015021-pol2qm74	7283	34	over	over	IN
cord-015021-pol2qm74	7283	35	days	day	NNS
cord-015021-pol2qm74	7283	36	.	.	.
cord-015021-pol2qm74	7284	1	Since	since	IN
cord-015021-pol2qm74	7284	2	we	-PRON-	PRP
cord-015021-pol2qm74	7284	3	administer	administer	VBP
cord-015021-pol2qm74	7284	4	clonidine	clonidine	NN
cord-015021-pol2qm74	7284	5	to	to	IN
cord-015021-pol2qm74	7284	6	patients	patient	NNS
cord-015021-pol2qm74	7284	7	with	with	IN
cord-015021-pol2qm74	7284	8	acute	acute	JJ
cord-015021-pol2qm74	7284	9	alcohol	alcohol	NN
cord-015021-pol2qm74	7284	10	abuse	abuse	NN
cord-015021-pol2qm74	7284	11	we	-PRON-	PRP
cord-015021-pol2qm74	7284	12	determined	determine	VBD
cord-015021-pol2qm74	7284	13	plasma	plasma	NN
cord-015021-pol2qm74	7284	14	levels	level	NNS
cord-015021-pol2qm74	7284	15	of	of	IN
cord-015021-pol2qm74	7284	16	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7284	17	and	and	CC
cord-015021-pol2qm74	7284	18	IGFBP-3	IGFBP-3	NNP
cord-015021-pol2qm74	7284	19	.	.	.
cord-015021-pol2qm74	7285	1	Materials	material	NNS
cord-015021-pol2qm74	7285	2	and	and	CC
cord-015021-pol2qm74	7285	3	methods	method	NNS
cord-015021-pol2qm74	7285	4	:	:	:
cord-015021-pol2qm74	7285	5	21	21	CD
cord-015021-pol2qm74	7285	6	patients	patient	NNS
cord-015021-pol2qm74	7285	7	sheduled	shedule	VBN
cord-015021-pol2qm74	7285	8	for	for	IN
cord-015021-pol2qm74	7285	9	esophagus	esophagus	NN
cord-015021-pol2qm74	7285	10	resection	resection	NN
cord-015021-pol2qm74	7285	11	were	be	VBD
cord-015021-pol2qm74	7285	12	investigated	investigate	VBN
cord-015021-pol2qm74	7285	13	once	once	IN
cord-015021-pol2qm74	7285	14	they	-PRON-	PRP
cord-015021-pol2qm74	7285	15	had	have	VBD
cord-015021-pol2qm74	7285	16	given	give	VBN
cord-015021-pol2qm74	7285	17	written	write	VBN
cord-015021-pol2qm74	7285	18	informed	informed	JJ
cord-015021-pol2qm74	7285	19	consent	consent	NN
cord-015021-pol2qm74	7285	20	.	.	.
cord-015021-pol2qm74	7286	1	8	8	CD
cord-015021-pol2qm74	7286	2	patients	patient	NNS
cord-015021-pol2qm74	7286	3	showed	show	VBD
cord-015021-pol2qm74	7286	4	acute	acute	JJ
cord-015021-pol2qm74	7286	5	alcohol	alcohol	NN
cord-015021-pol2qm74	7286	6	abuse	abuse	NN
cord-015021-pol2qm74	7286	7	and	and	CC
cord-015021-pol2qm74	7286	8	were	be	VBD
cord-015021-pol2qm74	7286	9	treated	treat	VBN
cord-015021-pol2qm74	7286	10	with	with	IN
cord-015021-pol2qm74	7286	11	clonidine	clonidine	NN
cord-015021-pol2qm74	7286	12	postoperatively•	postoperatively•	NNP
cord-015021-pol2qm74	7286	13	13	13	CD
cord-015021-pol2qm74	7286	14	Patients	patient	NNS
cord-015021-pol2qm74	7286	15	with	with	IN
cord-015021-pol2qm74	7286	16	no	no	DT
cord-015021-pol2qm74	7286	17	history	history	NN
cord-015021-pol2qm74	7286	18	of	of	IN
cord-015021-pol2qm74	7286	19	acute	acute	JJ
cord-015021-pol2qm74	7286	20	alcohol	alcohol	NN
cord-015021-pol2qm74	7286	21	abuse	abuse	NN
cord-015021-pol2qm74	7286	22	served	serve	VBD
cord-015021-pol2qm74	7286	23	as	as	IN
cord-015021-pol2qm74	7286	24	controls	control	NNS
cord-015021-pol2qm74	7286	25	.	.	.
cord-015021-pol2qm74	7287	1	Besides	besides	IN
cord-015021-pol2qm74	7287	2	liver	liver	NN
cord-015021-pol2qm74	7287	3	enzymes	enzyme	NNS
cord-015021-pol2qm74	7287	4	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7287	5	and	and	CC
cord-015021-pol2qm74	7287	6	IGFBP-3	IGFBP-3	NNP
cord-015021-pol2qm74	7287	7	were	be	VBD
cord-015021-pol2qm74	7287	8	determined	determine	VBN
cord-015021-pol2qm74	7287	9	.	.	.
cord-015021-pol2qm74	7288	1	Results	result	NNS
cord-015021-pol2qm74	7288	2	:	:	:
cord-015021-pol2qm74	7289	1	Both	both	DT
cord-015021-pol2qm74	7289	2	groups	group	NNS
cord-015021-pol2qm74	7289	3	had	have	VBD
cord-015021-pol2qm74	7289	4	a	a	DT
cord-015021-pol2qm74	7289	5	comparable	comparable	JJ
cord-015021-pol2qm74	7289	6	hepatic	hepatic	JJ
cord-015021-pol2qm74	7289	7	capacity	capacity	NN
cord-015021-pol2qm74	7289	8	of	of	IN
cord-015021-pol2qm74	7289	9	synthesis	synthesis	NN
cord-015021-pol2qm74	7289	10	with	with	IN
cord-015021-pol2qm74	7289	11	decreased	decrease	VBN
cord-015021-pol2qm74	7289	12	cholinesterase	cholinesterase	NN
cord-015021-pol2qm74	7289	13	levels	level	NNS
cord-015021-pol2qm74	7289	14	as	as	IN
cord-015021-pol2qm74	7289	15	to	to	TO
cord-015021-pol2qm74	7289	16	be	be	VB
cord-015021-pol2qm74	7289	17	expected	expect	VBN
cord-015021-pol2qm74	7289	18	after	after	IN
cord-015021-pol2qm74	7289	19	a	a	DT
cord-015021-pol2qm74	7289	20	major	major	JJ
cord-015021-pol2qm74	7289	21	operation	operation	NN
cord-015021-pol2qm74	7289	22	.	.	.
cord-015021-pol2qm74	7290	1	Regression	regression	NN
cord-015021-pol2qm74	7290	2	analysis	analysis	NN
cord-015021-pol2qm74	7290	3	of	of	IN
cord-015021-pol2qm74	7290	4	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7290	5	and	and	CC
cord-015021-pol2qm74	7290	6	IGFBP-3	IGFBP-3	NNP
cord-015021-pol2qm74	7290	7	levels	level	NNS
cord-015021-pol2qm74	7290	8	showed	show	VBD
cord-015021-pol2qm74	7290	9	no	no	DT
cord-015021-pol2qm74	7290	10	differences	difference	NNS
cord-015021-pol2qm74	7290	11	between	between	IN
cord-015021-pol2qm74	7290	12	the	the	DT
cord-015021-pol2qm74	7290	13	groups	group	NNS
cord-015021-pol2qm74	7290	14	.	.	.
cord-015021-pol2qm74	7291	1	Discussion	discussion	NN
cord-015021-pol2qm74	7291	2	:	:	:
cord-015021-pol2qm74	7292	1	IGF-1	IGF-1	NNP
cord-015021-pol2qm74	7292	2	and	and	CC
cord-015021-pol2qm74	7292	3	IGFBP-3	IGFBP-3	``
cord-015021-pol2qm74	7292	4	plasma	plasma	NN
cord-015021-pol2qm74	7292	5	levels	level	NNS
cord-015021-pol2qm74	7292	6	are	be	VBP
cord-015021-pol2qm74	7292	7	not	not	RB
cord-015021-pol2qm74	7292	8	increased	increase	VBN
cord-015021-pol2qm74	7292	9	in	in	IN
cord-015021-pol2qm74	7292	10	normotensive	normotensive	JJ
cord-015021-pol2qm74	7292	11	patients	patient	NNS
cord-015021-pol2qm74	7292	12	who	who	WP
cord-015021-pol2qm74	7292	13	are	be	VBP
cord-015021-pol2qm74	7292	14	treated	treat	VBN
cord-015021-pol2qm74	7292	15	with	with	IN
cord-015021-pol2qm74	7292	16	clonidine	clonidine	NN
cord-015021-pol2qm74	7292	17	for	for	IN
cord-015021-pol2qm74	7292	18	prevention	prevention	NN
cord-015021-pol2qm74	7292	19	of	of	IN
cord-015021-pol2qm74	7292	20	postoperative	postoperative	JJ
cord-015021-pol2qm74	7292	21	alcohol	alcohol	NN
cord-015021-pol2qm74	7292	22	withdrawl	withdrawl	NNP
cord-015021-pol2qm74	7292	23	syndrom	syndrom	NNP
cord-015021-pol2qm74	7292	24	.	.	.
cord-015021-pol2qm74	7293	1	Further	further	JJ
cord-015021-pol2qm74	7293	2	studies	study	NNS
cord-015021-pol2qm74	7293	3	are	be	VBP
cord-015021-pol2qm74	7293	4	required	require	VBN
cord-015021-pol2qm74	7293	5	to	to	TO
cord-015021-pol2qm74	7293	6	discriminate	discriminate	VB
cord-015021-pol2qm74	7293	7	whether	whether	IN
cord-015021-pol2qm74	7293	8	our	-PRON-	PRP$
cord-015021-pol2qm74	7293	9	results	result	NNS
cord-015021-pol2qm74	7293	10	are	be	VBP
cord-015021-pol2qm74	7293	11	due	due	JJ
cord-015021-pol2qm74	7293	12	to	to	IN
cord-015021-pol2qm74	7293	13	impaired	impaired	JJ
cord-015021-pol2qm74	7293	14	postoperative	postoperative	JJ
cord-015021-pol2qm74	7293	15	liver	liver	NN
cord-015021-pol2qm74	7293	16	function	function	NN
cord-015021-pol2qm74	7293	17	or	or	CC
cord-015021-pol2qm74	7293	18	if	if	IN
cord-015021-pol2qm74	7293	19	clonidine	clonidine	NN
cord-015021-pol2qm74	7293	20	has	have	VBZ
cord-015021-pol2qm74	7293	21	not	not	RB
cord-015021-pol2qm74	7293	22	any	any	DT
cord-015021-pol2qm74	7293	23	impact	impact	NN
cord-015021-pol2qm74	7293	24	on	on	IN
cord-015021-pol2qm74	7293	25	the	the	DT
cord-015021-pol2qm74	7293	26	GH	GH	NNP
cord-015021-pol2qm74	7293	27	-	-	HYPH
cord-015021-pol2qm74	7293	28	IGF	IGF	NNP
cord-015021-pol2qm74	7293	29	-	-	HYPH
cord-015021-pol2qm74	7293	30	axis	axis	NN
cord-015021-pol2qm74	7293	31	in	in	IN
cord-015021-pol2qm74	7293	32	patients	patient	NNS
cord-015021-pol2qm74	7293	33	with	with	IN
cord-015021-pol2qm74	7293	34	alcohol	alcohol	NN
cord-015021-pol2qm74	7293	35	abuse	abuse	NN
cord-015021-pol2qm74	7293	36	.	.	.
cord-015021-pol2qm74	7294	1	Recent	recent	JJ
cord-015021-pol2qm74	7294	2	studies	study	NNS
cord-015021-pol2qm74	7294	3	have	have	VBP
cord-015021-pol2qm74	7294	4	revealed	reveal	VBN
cord-015021-pol2qm74	7294	5	that	that	IN
cord-015021-pol2qm74	7294	6	IGF	IGF	NNP
cord-015021-pol2qm74	7294	7	-	-	:
cord-015021-pol2qm74	7294	8	I	-PRON-	PRP
cord-015021-pol2qm74	7294	9	has	have	VBZ
cord-015021-pol2qm74	7294	10	several	several	JJ
cord-015021-pol2qm74	7294	11	immanoregulatory	immanoregulatory	JJ
cord-015021-pol2qm74	7294	12	roles	role	NNS
cord-015021-pol2qm74	7294	13	.	.	.
cord-015021-pol2qm74	7295	1	However	however	RB
cord-015021-pol2qm74	7295	2	,	,	,
cord-015021-pol2qm74	7295	3	little	little	JJ
cord-015021-pol2qm74	7295	4	is	be	VBZ
cord-015021-pol2qm74	7295	5	known	know	VBN
cord-015021-pol2qm74	7295	6	about	about	IN
cord-015021-pol2qm74	7295	7	its	-PRON-	PRP$
cord-015021-pol2qm74	7295	8	effects	effect	NNS
cord-015021-pol2qm74	7295	9	on	on	IN
cord-015021-pol2qm74	7295	10	septic	septic	JJ
cord-015021-pol2qm74	7295	11	animals	animal	NNS
cord-015021-pol2qm74	7295	12	.	.	.
cord-015021-pol2qm74	7296	1	We	-PRON-	PRP
cord-015021-pol2qm74	7296	2	tested	test	VBD
cord-015021-pol2qm74	7296	3	whether	whether	IN
cord-015021-pol2qm74	7296	4	IGF	IGF	NNP
cord-015021-pol2qm74	7296	5	-	-	:
cord-015021-pol2qm74	7296	6	I	-PRON-	PRP
cord-015021-pol2qm74	7296	7	could	could	MD
cord-015021-pol2qm74	7296	8	increase	increase	VB
cord-015021-pol2qm74	7296	9	the	the	DT
cord-015021-pol2qm74	7296	10	survival	survival	NN
cord-015021-pol2qm74	7296	11	O	o	NN
cord-015021-pol2qm74	7296	12	f	f	NN
cord-015021-pol2qm74	7296	13	mice	mouse	NNS
cord-015021-pol2qm74	7296	14	challenged	challenge	VBD
cord-015021-pol2qm74	7296	15	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	7296	16	(	(	-LRB-
cord-015021-pol2qm74	7296	17	i.p	i.p	NNP
cord-015021-pol2qm74	7296	18	.	.	NNP
cord-015021-pol2qm74	7296	19	)	)	-RRB-
cord-015021-pol2qm74	7296	20	with	with	IN
cord-015021-pol2qm74	7296	21	E.	E.	NNP
cord-015021-pol2qm74	7296	22	coli	coli	NNS
cord-015021-pol2qm74	7296	23	.	.	.
cord-015021-pol2qm74	7297	1	M~	M~	NNP
cord-015021-pol2qm74	7298	1	THQD$	THQD$	NNP
cord-015021-pol2qm74	7298	2	BALB	BALB	NNP
cord-015021-pol2qm74	7298	3	/	/	SYM
cord-015021-pol2qm74	7298	4	c	c	NN
cord-015021-pol2qm74	7298	5	mice	mouse	NNS
cord-015021-pol2qm74	7298	6	received	receive	VBD
cord-015021-pol2qm74	7298	7	either	either	CC
cord-015021-pol2qm74	7298	8	high	high	JJ
cord-015021-pol2qm74	7298	9	dose	dose	NN
cord-015021-pol2qm74	7298	10	IGF	IGF	NNP
cord-015021-pol2qm74	7298	11	-	-	HYPH
cord-015021-pol2qm74	7298	12	I	I	NNP
cord-015021-pol2qm74	7298	13	(	(	-LRB-
cord-015021-pol2qm74	7298	14	n=10	n=10	NNP
cord-015021-pol2qm74	7298	15	,	,	,
cord-015021-pol2qm74	7298	16	24mg	24mg	NNP
cord-015021-pol2qm74	7298	17	/	/	SYM
cord-015021-pol2qm74	7298	18	kg	kg	NN
cord-015021-pol2qm74	7298	19	/	/	SYM
cord-015021-pol2qm74	7298	20	day	day	NN
cord-015021-pol2qm74	7298	21	)	)	-RRB-
cord-015021-pol2qm74	7298	22	,	,	,
cord-015021-pol2qm74	7298	23	low	low	JJ
cord-015021-pol2qm74	7298	24	dose	dose	NN
cord-015021-pol2qm74	7298	25	IGF	IGF	NNP
cord-015021-pol2qm74	7298	26	-	-	HYPH
cord-015021-pol2qm74	7298	27	I	I	NNP
cord-015021-pol2qm74	7298	28	(	(	-LRB-
cord-015021-pol2qm74	7298	29	n=10	n=10	NNP
cord-015021-pol2qm74	7298	30	,	,	,
cord-015021-pol2qm74	7298	31	2.4mg	2.4mg	CD
cord-015021-pol2qm74	7298	32	/	/	SYM
cord-015021-pol2qm74	7298	33	kg	kg	NN
cord-015021-pol2qm74	7298	34	/	/	SYM
cord-015021-pol2qm74	7298	35	day	day	NN
cord-015021-pol2qm74	7298	36	)	)	-RRB-
cord-015021-pol2qm74	7298	37	or	or	CC
cord-015021-pol2qm74	7298	38	saline	saline	NN
cord-015021-pol2qm74	7298	39	(	(	-LRB-
cord-015021-pol2qm74	7298	40	11=10	11=10	CD
cord-015021-pol2qm74	7298	41	)	)	-RRB-
cord-015021-pol2qm74	7299	1	every	every	DT
cord-015021-pol2qm74	7299	2	eight	eight	CD
cord-015021-pol2qm74	7299	3	hours	hour	NNS
cord-015021-pol2qm74	7299	4	subcutaneously	subcutaneously	RB
cord-015021-pol2qm74	7299	5	for	for	IN
cord-015021-pol2qm74	7299	6	six	six	CD
cord-015021-pol2qm74	7299	7	days	day	NNS
cord-015021-pol2qm74	7299	8	.	.	.
cord-015021-pol2qm74	7300	1	Animals	animal	NNS
cord-015021-pol2qm74	7300	2	were	be	VBD
cord-015021-pol2qm74	7300	3	then	then	RB
cord-015021-pol2qm74	7300	4	challenged	challenge	VBN
cord-015021-pol2qm74	7300	5	i.p	i.p	NNP
cord-015021-pol2qm74	7300	6	.	.	NNP
cord-015021-pol2qm74	7300	7	with	with	IN
cord-015021-pol2qm74	7300	8	lx108	lx108	NNP
cord-015021-pol2qm74	7300	9	E.	E.	NNP
cord-015021-pol2qm74	7300	10	coli	coli	NNS
cord-015021-pol2qm74	7300	11	.	.	.
cord-015021-pol2qm74	7301	1	Survival	survival	NN
cord-015021-pol2qm74	7301	2	was	be	VBD
cord-015021-pol2qm74	7301	3	observed	observe	VBN
cord-015021-pol2qm74	7301	4	every	every	DT
cord-015021-pol2qm74	7301	5	two	two	CD
cord-015021-pol2qm74	7301	6	hours	hour	NNS
cord-015021-pol2qm74	7301	7	.	.	.
cord-015021-pol2qm74	7302	1	In	in	IN
cord-015021-pol2qm74	7302	2	the	the	DT
cord-015021-pol2qm74	7302	3	other	other	JJ
cord-015021-pol2qm74	7302	4	experiment	experiment	NN
cord-015021-pol2qm74	7302	5	,	,	,
cord-015021-pol2qm74	7302	6	mice	mouse	NNS
cord-015021-pol2qm74	7302	7	that	that	WDT
cord-015021-pol2qm74	7302	8	received	receive	VBD
cord-015021-pol2qm74	7302	9	high	high	JJ
cord-015021-pol2qm74	7302	10	dose	dose	NN
cord-015021-pol2qm74	7302	11	IGF	IGF	NNP
cord-015021-pol2qm74	7302	12	-	-	HYPH
cord-015021-pol2qm74	7302	13	I	i	NN
cord-015021-pol2qm74	7302	14	or	or	CC
cord-015021-pol2qm74	7302	15	saline	saline	NN
cord-015021-pol2qm74	7302	16	were	be	VBD
cord-015021-pol2qm74	7302	17	sacrificed	sacrifice	VBN
cord-015021-pol2qm74	7302	18	four	four	CD
cord-015021-pol2qm74	7302	19	hours	hour	NNS
cord-015021-pol2qm74	7302	20	after	after	IN
cord-015021-pol2qm74	7302	21	bacterial	bacterial	JJ
cord-015021-pol2qm74	7302	22	challenge	challenge	NN
cord-015021-pol2qm74	7302	23	.	.	.
cord-015021-pol2qm74	7303	1	Peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7303	2	cavity	cavity	NN
cord-015021-pol2qm74	7303	3	was	be	VBD
cord-015021-pol2qm74	7303	4	lavaged	lavage	VBN
cord-015021-pol2qm74	7303	5	with	with	IN
cord-015021-pol2qm74	7303	6	3ml	3ml	NN
cord-015021-pol2qm74	7303	7	saline	saline	NN
cord-015021-pol2qm74	7303	8	and	and	CC
cord-015021-pol2qm74	7303	9	the	the	DT
cord-015021-pol2qm74	7303	10	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7303	11	exudative	exudative	NNP
cord-015021-pol2qm74	7303	12	ceils	ceils	NNP
cord-015021-pol2qm74	7303	13	(	(	-LRB-
cord-015021-pol2qm74	7303	14	PEC	PEC	NNP
cord-015021-pol2qm74	7303	15	)	)	-RRB-
cord-015021-pol2qm74	7303	16	were	be	VBD
cord-015021-pol2qm74	7303	17	harvested	harvest	VBN
cord-015021-pol2qm74	7303	18	and	and	CC
cord-015021-pol2qm74	7303	19	counted	count	VBN
cord-015021-pol2qm74	7303	20	.	.	.
cord-015021-pol2qm74	7304	1	Colony	colony	NN
cord-015021-pol2qm74	7304	2	forming	form	VBG
cord-015021-pol2qm74	7304	3	units	unit	NNS
cord-015021-pol2qm74	7304	4	(	(	-LRB-
cord-015021-pol2qm74	7304	5	CFU	CFU	NNP
cord-015021-pol2qm74	7304	6	)	)	-RRB-
cord-015021-pol2qm74	7304	7	of	of	IN
cord-015021-pol2qm74	7304	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	7304	9	in	in	IN
cord-015021-pol2qm74	7304	10	the	the	DT
cord-015021-pol2qm74	7304	11	peritoneal	peritoneal	NN
cord-015021-pol2qm74	7304	12	lavaged	lavaged	NN
cord-015021-pol2qm74	7304	13	fluid	fluid	NN
cord-015021-pol2qm74	7304	14	(	(	-LRB-
cord-015021-pol2qm74	7304	15	PLF	PLF	NNP
cord-015021-pol2qm74	7304	16	)	)	-RRB-
cord-015021-pol2qm74	7304	17	,	,	,
cord-015021-pol2qm74	7304	18	liver	liver	NN
cord-015021-pol2qm74	7304	19	,	,	,
cord-015021-pol2qm74	7304	20	lung	lung	NN
cord-015021-pol2qm74	7304	21	and	and	CC
cord-015021-pol2qm74	7304	22	blood	blood	NN
cord-015021-pol2qm74	7304	23	were	be	VBD
cord-015021-pol2qm74	7304	24	determined	determine	VBN
cord-015021-pol2qm74	7304	25	.	.	.
cord-015021-pol2qm74	7305	1	In	in	IN
cord-015021-pol2qm74	7305	2	addition	addition	NN
cord-015021-pol2qm74	7305	3	,	,	,
cord-015021-pol2qm74	7305	4	PEC	PEC	NNP
cord-015021-pol2qm74	7305	5	were	be	VBD
cord-015021-pol2qm74	7305	6	cultured	culture	VBN
cord-015021-pol2qm74	7305	7	/	/	SYM
cord-015021-pol2qm74	7305	8	n	n	CC
cord-015021-pol2qm74	7305	9	vitro	vitro	FW
cord-015021-pol2qm74	7305	10	for	for	IN
cord-015021-pol2qm74	7305	11	24	24	CD
cord-015021-pol2qm74	7305	12	hours	hour	NNS
cord-015021-pol2qm74	7305	13	with	with	IN
cord-015021-pol2qm74	7305	14	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	7305	15	(	(	-LRB-
cord-015021-pol2qm74	7305	16	10).tg	10).tg	CD
cord-015021-pol2qm74	7305	17	/	/	SYM
cord-015021-pol2qm74	7305	18	ml	ml	NN
cord-015021-pol2qm74	7305	19	)	)	-RRB-
cord-015021-pol2qm74	7305	20	.	.	.
cord-015021-pol2qm74	7306	1	Tumor	tumor	NN
cord-015021-pol2qm74	7306	2	necrosis	necrosis	NN
cord-015021-pol2qm74	7306	3	factor	factor	NN
cord-015021-pol2qm74	7306	4	(	(	-LRB-
cord-015021-pol2qm74	7306	5	TNF	TNF	NNP
cord-015021-pol2qm74	7306	6	)	)	-RRB-
cord-015021-pol2qm74	7306	7	in	in	IN
cord-015021-pol2qm74	7306	8	the	the	DT
cord-015021-pol2qm74	7306	9	supernatants	supernatant	NNS
cord-015021-pol2qm74	7306	10	of	of	IN
cord-015021-pol2qm74	7306	11	PEC	pec	NN
cord-015021-pol2qm74	7306	12	culture	culture	NN
cord-015021-pol2qm74	7306	13	,	,	,
cord-015021-pol2qm74	7306	14	PLF	PLF	NNP
cord-015021-pol2qm74	7306	15	and	and	CC
cord-015021-pol2qm74	7306	16	serum	serum	NN
cord-015021-pol2qm74	7306	17	were	be	VBD
cord-015021-pol2qm74	7306	18	measured	measure	VBN
cord-015021-pol2qm74	7306	19	by	by	IN
cord-015021-pol2qm74	7306	20	L929	l929	CD
cord-015021-pol2qm74	7306	21	bioassay	bioassay	NN
cord-015021-pol2qm74	7306	22	.	.	.
cord-015021-pol2qm74	7307	1	RESULTS	result	NNS
cord-015021-pol2qm74	7307	2	IGF	IGF	NNP
cord-015021-pol2qm74	7308	1	-I	-i	WDT
cord-015021-pol2qm74	7308	2	improved	improve	VBD
cord-015021-pol2qm74	7308	3	the	the	DT
cord-015021-pol2qm74	7308	4	survival	survival	NN
cord-015021-pol2qm74	7308	5	rate	rate	NN
cord-015021-pol2qm74	7308	6	at	at	IN
cord-015021-pol2qm74	7308	7	a	a	DT
cord-015021-pol2qm74	7308	8	dose	dose	NN
cord-015021-pol2qm74	7308	9	of	of	IN
cord-015021-pol2qm74	7308	10	24mg	24mg	NN
cord-015021-pol2qm74	7308	11	/	/	SYM
cord-015021-pol2qm74	7308	12	kg	kg	NN
cord-015021-pol2qm74	7308	13	/	/	SYM
cord-015021-pol2qm74	7308	14	day	day	NN
cord-015021-pol2qm74	7308	15	.	.	.
cord-015021-pol2qm74	7309	1	Severe	severe	JJ
cord-015021-pol2qm74	7309	2	chronic	chronic	JJ
cord-015021-pol2qm74	7309	3	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7309	4	(	(	-LRB-
cord-015021-pol2qm74	7309	5	SCN	SCN	NNP
cord-015021-pol2qm74	7309	6	)	)	-RRB-
cord-015021-pol2qm74	7309	7	is	be	VBZ
cord-015021-pol2qm74	7309	8	a	a	DT
cord-015021-pol2qm74	7309	9	disorder	disorder	NN
cord-015021-pol2qm74	7309	10	characterized	characterize	VBN
cord-015021-pol2qm74	7309	11	by	by	IN
cord-015021-pol2qm74	7309	12	severe	severe	JJ
cord-015021-pol2qm74	7309	13	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7309	14	secondary	secondary	JJ
cord-015021-pol2qm74	7309	15	to	to	IN
cord-015021-pol2qm74	7309	16	either	either	CC
cord-015021-pol2qm74	7309	17	a	a	DT
cord-015021-pol2qm74	7309	18	maturational	maturational	JJ
cord-015021-pol2qm74	7309	19	arrest	arrest	NN
cord-015021-pol2qm74	7309	20	of	of	IN
cord-015021-pol2qm74	7309	21	myelopoiesis	myelopoiesis	NN
cord-015021-pol2qm74	7309	22	at	at	IN
cord-015021-pol2qm74	7309	23	the	the	DT
cord-015021-pol2qm74	7309	24	level	level	NN
cord-015021-pol2qm74	7309	25	of	of	IN
cord-015021-pol2qm74	7309	26	promyelocytes	promyelocyte	NNS
cord-015021-pol2qm74	7309	27	(	(	-LRB-
cord-015021-pol2qm74	7309	28	Kostmann	Kostmann	NNP
cord-015021-pol2qm74	7309	29	-	-	HYPH
cord-015021-pol2qm74	7309	30	Syndrome	Syndrome	NNP
cord-015021-pol2qm74	7309	31	;	;	:
cord-015021-pol2qm74	7309	32	SCN	SCN	NNP
cord-015021-pol2qm74	7309	33	)	)	-RRB-
cord-015021-pol2qm74	7309	34	or	or	CC
cord-015021-pol2qm74	7309	35	regular	regular	JJ
cord-015021-pol2qm74	7309	36	cyclic	cyclic	JJ
cord-015021-pol2qm74	7309	37	fluctuations	fluctuation	NNS
cord-015021-pol2qm74	7309	38	in	in	IN
cord-015021-pol2qm74	7309	39	the	the	DT
cord-015021-pol2qm74	7309	40	number	number	NN
cord-015021-pol2qm74	7309	41	of	of	IN
cord-015021-pol2qm74	7309	42	blood	blood	NN
cord-015021-pol2qm74	7309	43	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7309	44	with	with	IN
cord-015021-pol2qm74	7309	45	a	a	DT
cord-015021-pol2qm74	7309	46	median	median	JJ
cord-015021-pol2qm74	7309	47	absolute	absolute	JJ
cord-015021-pol2qm74	7309	48	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7309	49	count	count	NN
cord-015021-pol2qm74	7309	50	(	(	-LRB-
cord-015021-pol2qm74	7309	51	ANC	ANC	NNP
cord-015021-pol2qm74	7309	52	)	)	-RRB-
cord-015021-pol2qm74	7309	53	of	of	IN
cord-015021-pol2qm74	7309	54	less	less	JJR
cord-015021-pol2qm74	7309	55	than	than	IN
cord-015021-pol2qm74	7309	56	500/~tl	500/~tl	CD
cord-015021-pol2qm74	7309	57	(	(	-LRB-
cord-015021-pol2qm74	7309	58	cyclic	cyclic	JJ
cord-015021-pol2qm74	7309	59	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7309	60	)	)	-RRB-
cord-015021-pol2qm74	7309	61	.	.	.
cord-015021-pol2qm74	7310	1	Patients	patient	NNS
cord-015021-pol2qm74	7310	2	suffering	suffer	VBG
cord-015021-pol2qm74	7310	3	from	from	IN
cord-015021-pol2qm74	7310	4	SCN	SCN	NNP
cord-015021-pol2qm74	7310	5	have	have	VBP
cord-015021-pol2qm74	7310	6	an	an	DT
cord-015021-pol2qm74	7310	7	impaired	impaired	JJ
cord-015021-pol2qm74	7310	8	acute	acute	JJ
cord-015021-pol2qm74	7310	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7310	10	response	response	NN
cord-015021-pol2qm74	7310	11	to	to	IN
cord-015021-pol2qm74	7310	12	injury	injury	NN
cord-015021-pol2qm74	7310	13	and	and	CC
cord-015021-pol2qm74	7310	14	an	an	DT
cord-015021-pol2qm74	7310	15	increased	increase	VBN
cord-015021-pol2qm74	7310	16	susceptibility	susceptibility	NN
cord-015021-pol2qm74	7310	17	to	to	IN
cord-015021-pol2qm74	7310	18	infections	infection	NNS
cord-015021-pol2qm74	7310	19	,	,	,
cord-015021-pol2qm74	7310	20	i.e.	i.e.	FW
cord-015021-pol2qm74	7310	21	bacterial	bacterial	JJ
cord-015021-pol2qm74	7310	22	or	or	CC
cord-015021-pol2qm74	7310	23	fungal	fungal	JJ
cord-015021-pol2qm74	7310	24	infections	infection	NNS
cord-015021-pol2qm74	7310	25	,	,	,
cord-015021-pol2qm74	7310	26	resulting	result	VBG
cord-015021-pol2qm74	7310	27	in	in	IN
cord-015021-pol2qm74	7310	28	chronic	chronic	JJ
cord-015021-pol2qm74	7310	29	oral	oral	JJ
cord-015021-pol2qm74	7310	30	inflammation	inflammation	NN
cord-015021-pol2qm74	7310	31	,	,	,
cord-015021-pol2qm74	7310	32	severe	severe	JJ
cord-015021-pol2qm74	7310	33	pneumonia	pneumonia	NN
cord-015021-pol2qm74	7310	34	,	,	,
cord-015021-pol2qm74	7310	35	abscess	abscess	NN
cord-015021-pol2qm74	7310	36	formation	formation	NN
cord-015021-pol2qm74	7310	37	and	and	CC
cord-015021-pol2qm74	7310	38	bacteraemia	bacteraemia	NN
cord-015021-pol2qm74	7310	39	.	.	.
cord-015021-pol2qm74	7311	1	We	-PRON-	PRP
cord-015021-pol2qm74	7311	2	have	have	VBP
cord-015021-pol2qm74	7311	3	treated	treat	VBN
cord-015021-pol2qm74	7311	4	36	36	CD
cord-015021-pol2qm74	7311	5	patients	patient	NNS
cord-015021-pol2qm74	7311	6	(	(	-LRB-
cord-015021-pol2qm74	7311	7	32	32	CD
cord-015021-pol2qm74	7311	8	SCN	SCN	NNP
cord-015021-pol2qm74	7311	9	,	,	,
cord-015021-pol2qm74	7311	10	4	4	CD
cord-015021-pol2qm74	7311	11	cyclic	cyclic	JJ
cord-015021-pol2qm74	7311	12	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7311	13	)	)	-RRB-
cord-015021-pol2qm74	7311	14	with	with	IN
cord-015021-pol2qm74	7311	15	r	r	NNP
cord-015021-pol2qm74	7311	16	-	-	HYPH
cord-015021-pol2qm74	7311	17	metHuG	metHuG	NNP
cord-015021-pol2qm74	7311	18	-	-	HYPH
cord-015021-pol2qm74	7311	19	CSF	CSF	NNP
cord-015021-pol2qm74	7311	20	(	(	-LRB-
cord-015021-pol2qm74	7311	21	filgrastim	filgrastim	NNP
cord-015021-pol2qm74	7311	22	)	)	-RRB-
cord-015021-pol2qm74	7311	23	.	.	.
cord-015021-pol2qm74	7312	1	Thirty	thirty	CD
cord-015021-pol2qm74	7312	2	of	of	IN
cord-015021-pol2qm74	7312	3	32	32	CD
cord-015021-pol2qm74	7312	4	patients	patient	NNS
cord-015021-pol2qm74	7312	5	with	with	IN
cord-015021-pol2qm74	7312	6	SCN	SCN	NNP
cord-015021-pol2qm74	7312	7	and	and	CC
cord-015021-pol2qm74	7312	8	all	all	DT
cord-015021-pol2qm74	7312	9	4	4	CD
cord-015021-pol2qm74	7312	10	cyclic	cyclic	JJ
cord-015021-pol2qm74	7312	11	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7312	12	patients	patient	NNS
cord-015021-pol2qm74	7312	13	responded	respond	VBD
cord-015021-pol2qm74	7312	14	to	to	IN
cord-015021-pol2qm74	7312	15	this	this	DT
cord-015021-pol2qm74	7312	16	treatment	treatment	NN
cord-015021-pol2qm74	7312	17	with	with	IN
cord-015021-pol2qm74	7312	18	an	an	DT
cord-015021-pol2qm74	7312	19	increase	increase	NN
cord-015021-pol2qm74	7312	20	of	of	IN
cord-015021-pol2qm74	7312	21	the	the	DT
cord-015021-pol2qm74	7312	22	median	median	JJ
cord-015021-pol2qm74	7312	23	ANC	ANC	NNP
cord-015021-pol2qm74	7312	24	to	to	IN
cord-015021-pol2qm74	7312	25	greater	great	JJR
cord-015021-pol2qm74	7312	26	than	than	IN
cord-015021-pol2qm74	7312	27	1000/~tl	1000/~tl	CD
cord-015021-pol2qm74	7312	28	.	.	.
cord-015021-pol2qm74	7313	1	The	the	DT
cord-015021-pol2qm74	7313	2	dose	dose	NN
cord-015021-pol2qm74	7313	3	of	of	IN
cord-015021-pol2qm74	7313	4	r	r	JJ
cord-015021-pol2qm74	7313	5	-	-	HYPH
cord-015021-pol2qm74	7313	6	metHuG	metHuG	NNP
cord-015021-pol2qm74	7313	7	-	-	HYPH
cord-015021-pol2qm74	7313	8	CSF	CSF	NNP
cord-015021-pol2qm74	7313	9	needed	need	VBD
cord-015021-pol2qm74	7313	10	to	to	TO
cord-015021-pol2qm74	7313	11	achieve	achieve	VB
cord-015021-pol2qm74	7313	12	and	and	CC
cord-015021-pol2qm74	7313	13	maintain	maintain	VB
cord-015021-pol2qm74	7313	14	the	the	DT
cord-015021-pol2qm74	7313	15	response	response	NN
cord-015021-pol2qm74	7313	16	varied	vary	VBN
cord-015021-pol2qm74	7313	17	between	between	IN
cord-015021-pol2qm74	7313	18	0.8	0.8	CD
cord-015021-pol2qm74	7313	19	and	and	CC
cord-015021-pol2qm74	7313	20	120	120	CD
cord-015021-pol2qm74	7314	1	~tg	~tg	NNP
cord-015021-pol2qm74	7314	2	/	/	SYM
cord-015021-pol2qm74	7314	3	kg	kg	NN
cord-015021-pol2qm74	7314	4	/	/	SYM
cord-015021-pol2qm74	7314	5	d	d	NN
cord-015021-pol2qm74	7314	6	.	.	.
cord-015021-pol2qm74	7315	1	Long	long	JJ
cord-015021-pol2qm74	7315	2	-	-	HYPH
cord-015021-pol2qm74	7315	3	term	term	NN
cord-015021-pol2qm74	7315	4	treatment	treatment	NN
cord-015021-pol2qm74	7315	5	did	do	VBD
cord-015021-pol2qm74	7315	6	not	not	RB
cord-015021-pol2qm74	7315	7	exhaust	exhaust	VB
cord-015021-pol2qm74	7315	8	myelopoiesis	myelopoiesis	NN
cord-015021-pol2qm74	7315	9	:	:	:
cord-015021-pol2qm74	7315	10	the	the	DT
cord-015021-pol2qm74	7315	11	ANC	ANC	NNP
cord-015021-pol2qm74	7315	12	remained	remain	VBD
cord-015021-pol2qm74	7315	13	stable	stable	JJ
cord-015021-pol2qm74	7315	14	after	after	IN
cord-015021-pol2qm74	7315	15	up	up	IN
cord-015021-pol2qm74	7315	16	to	to	TO
cord-015021-pol2qm74	7315	17	6	6	CD
cord-015021-pol2qm74	7315	18	years	year	NNS
cord-015021-pol2qm74	7315	19	of	of	IN
cord-015021-pol2qm74	7315	20	treatment	treatment	NN
cord-015021-pol2qm74	7315	21	and	and	CC
cord-015021-pol2qm74	7315	22	antibodies	antibody	NNS
cord-015021-pol2qm74	7315	23	to	to	IN
cord-015021-pol2qm74	7316	1	r	r	LS
cord-015021-pol2qm74	7316	2	-	-	:
cord-015021-pol2qm74	7316	3	metHuG	metHuG	NNP
cord-015021-pol2qm74	7316	4	-	-	HYPH
cord-015021-pol2qm74	7316	5	CSF	CSF	NNP
cord-015021-pol2qm74	7316	6	were	be	VBD
cord-015021-pol2qm74	7316	7	not	not	RB
cord-015021-pol2qm74	7316	8	detected	detect	VBN
cord-015021-pol2qm74	7316	9	.	.	.
cord-015021-pol2qm74	7317	1	The	the	DT
cord-015021-pol2qm74	7317	2	increase	increase	NN
cord-015021-pol2qm74	7317	3	of	of	IN
cord-015021-pol2qm74	7317	4	ANC	ANC	NNP
cord-015021-pol2qm74	7317	5	was	be	VBD
cord-015021-pol2qm74	7317	6	associated	associate	VBN
cord-015021-pol2qm74	7317	7	with	with	IN
cord-015021-pol2qm74	7317	8	dramatic	dramatic	JJ
cord-015021-pol2qm74	7317	9	clinical	clinical	JJ
cord-015021-pol2qm74	7317	10	responses	response	NNS
cord-015021-pol2qm74	7317	11	:	:	:
cord-015021-pol2qm74	7317	12	significant	significant	JJ
cord-015021-pol2qm74	7317	13	reduction	reduction	NN
cord-015021-pol2qm74	7317	14	of	of	IN
cord-015021-pol2qm74	7317	15	severe	severe	JJ
cord-015021-pol2qm74	7317	16	bacterial	bacterial	JJ
cord-015021-pol2qm74	7317	17	infections	infection	NNS
cord-015021-pol2qm74	7317	18	,	,	,
cord-015021-pol2qm74	7317	19	reduction	reduction	NN
cord-015021-pol2qm74	7317	20	of	of	IN
cord-015021-pol2qm74	7317	21	intravenous	intravenous	JJ
cord-015021-pol2qm74	7317	22	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	7317	23	treatment	treatment	NN
cord-015021-pol2qm74	7317	24	,	,	,
cord-015021-pol2qm74	7317	25	and	and	CC
cord-015021-pol2qm74	7317	26	reduction	reduction	NN
cord-015021-pol2qm74	7317	27	of	of	IN
cord-015021-pol2qm74	7317	28	hospitalizations	hospitalization	NNS
cord-015021-pol2qm74	7317	29	.	.	.
cord-015021-pol2qm74	7318	1	No	no	DT
cord-015021-pol2qm74	7318	2	severe	severe	JJ
cord-015021-pol2qm74	7318	3	bacterial	bacterial	JJ
cord-015021-pol2qm74	7318	4	infections	infection	NNS
cord-015021-pol2qm74	7318	5	occurred	occur	VBD
cord-015021-pol2qm74	7318	6	in	in	IN
cord-015021-pol2qm74	7318	7	any	any	DT
cord-015021-pol2qm74	7318	8	of	of	IN
cord-015021-pol2qm74	7318	9	the	the	DT
cord-015021-pol2qm74	7318	10	r	r	NN
cord-015021-pol2qm74	7318	11	-	-	HYPH
cord-015021-pol2qm74	7318	12	rnetHuG	rnetHuG	NNP
cord-015021-pol2qm74	7318	13	-	-	HYPH
cord-015021-pol2qm74	7318	14	CSF	csf	NN
cord-015021-pol2qm74	7318	15	responders	responder	NNS
cord-015021-pol2qm74	7318	16	during	during	IN
cord-015021-pol2qm74	7318	17	longterm	longterm	JJ
cord-015021-pol2qm74	7318	18	treatment	treatment	NN
cord-015021-pol2qm74	7318	19	.	.	.
cord-015021-pol2qm74	7319	1	Severe	severe	JJ
cord-015021-pol2qm74	7319	2	adverse	adverse	JJ
cord-015021-pol2qm74	7319	3	events	event	NNS
cord-015021-pol2qm74	7319	4	,	,	,
cord-015021-pol2qm74	7319	5	most	most	RBS
cord-015021-pol2qm74	7319	6	likely	likely	JJ
cord-015021-pol2qm74	7319	7	due	due	IN
cord-015021-pol2qm74	7319	8	to	to	IN
cord-015021-pol2qm74	7319	9	the	the	DT
cord-015021-pol2qm74	7319	10	underlying	underlie	VBG
cord-015021-pol2qm74	7319	11	disease	disease	NN
cord-015021-pol2qm74	7319	12	,	,	,
cord-015021-pol2qm74	7319	13	included	include	VBD
cord-015021-pol2qm74	7319	14	the	the	DT
cord-015021-pol2qm74	7319	15	development	development	NN
cord-015021-pol2qm74	7319	16	of	of	IN
cord-015021-pol2qm74	7319	17	MDS	MDS	NNP
cord-015021-pol2qm74	7319	18	/	/	SYM
cord-015021-pol2qm74	7319	19	Leukemia	Leukemia	NNP
cord-015021-pol2qm74	7319	20	in	in	IN
cord-015021-pol2qm74	7319	21	two	two	CD
cord-015021-pol2qm74	7319	22	patients	patient	NNS
cord-015021-pol2qm74	7319	23	,	,	,
cord-015021-pol2qm74	7319	24	and	and	CC
cord-015021-pol2qm74	7319	25	osteopenia	osteopenia	NN
cord-015021-pol2qm74	7319	26	/	/	SYM
cord-015021-pol2qm74	7319	27	osteoporosis	osteoporosis	NN
cord-015021-pol2qm74	7319	28	in	in	IN
cord-015021-pol2qm74	7319	29	12	12	CD
cord-015021-pol2qm74	7319	30	patients	patient	NNS
cord-015021-pol2qm74	7319	31	.	.	.
cord-015021-pol2qm74	7320	1	These	these	DT
cord-015021-pol2qm74	7320	2	results	result	NNS
cord-015021-pol2qm74	7320	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	7320	4	the	the	DT
cord-015021-pol2qm74	7320	5	beneficial	beneficial	JJ
cord-015021-pol2qm74	7320	6	effects	effect	NNS
cord-015021-pol2qm74	7320	7	of	of	IN
cord-015021-pol2qm74	7320	8	r	r	NN
cord-015021-pol2qm74	7320	9	-	-	HYPH
cord-015021-pol2qm74	7320	10	metHuG	metHuG	NNP
cord-015021-pol2qm74	7320	11	-	-	HYPH
cord-015021-pol2qm74	7320	12	CSF	csf	NN
cord-015021-pol2qm74	7320	13	treatment	treatment	NN
cord-015021-pol2qm74	7320	14	in	in	IN
cord-015021-pol2qm74	7320	15	severe	severe	JJ
cord-015021-pol2qm74	7320	16	chronic	chronic	JJ
cord-015021-pol2qm74	7320	17	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7320	18	patients	patient	NNS
cord-015021-pol2qm74	7320	19	.	.	.
cord-015021-pol2qm74	7321	1	The	the	DT
cord-015021-pol2qm74	7321	2	newborn	newborn	NN
cord-015021-pol2qm74	7321	3	is	be	VBZ
cord-015021-pol2qm74	7321	4	predisposed	predisposed	JJ
cord-015021-pol2qm74	7321	5	to	to	IN
cord-015021-pol2qm74	7321	6	mortality	mortality	NN
cord-015021-pol2qm74	7321	7	during	during	IN
cord-015021-pol2qm74	7321	8	infections	infection	NNS
cord-015021-pol2qm74	7321	9	due	due	JJ
cord-015021-pol2qm74	7321	10	in	in	IN
cord-015021-pol2qm74	7321	11	large	large	JJ
cord-015021-pol2qm74	7321	12	part	part	NN
cord-015021-pol2qm74	7321	13	to	to	IN
cord-015021-pol2qm74	7321	14	developmentally	developmentally	RB
cord-015021-pol2qm74	7321	15	immature	immature	JJ
cord-015021-pol2qm74	7321	16	host	host	NN
cord-015021-pol2qm74	7321	17	defenses	defense	NNS
cord-015021-pol2qm74	7321	18	.	.	.
cord-015021-pol2qm74	7322	1	Recently	recently	RB
cord-015021-pol2qm74	7322	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	7322	3	have	have	VBP
cord-015021-pol2qm74	7322	4	been	be	VBN
cord-015021-pol2qm74	7322	5	identified	identify	VBN
cord-015021-pol2qm74	7322	6	that	that	WDT
cord-015021-pol2qm74	7322	7	regulate	regulate	VBP
cord-015021-pol2qm74	7322	8	the	the	DT
cord-015021-pol2qm74	7322	9	development	development	NN
cord-015021-pol2qm74	7322	10	of	of	IN
cord-015021-pol2qm74	7322	11	these	these	DT
cord-015021-pol2qm74	7322	12	defenses	defense	NNS
cord-015021-pol2qm74	7322	13	.	.	.
cord-015021-pol2qm74	7323	1	One	one	CD
cord-015021-pol2qm74	7323	2	such	such	JJ
cord-015021-pol2qm74	7323	3	cytokine	cytokine	NN
cord-015021-pol2qm74	7323	4	is	be	VBZ
cord-015021-pol2qm74	7323	5	specific	specific	JJ
cord-015021-pol2qm74	7323	6	for	for	IN
cord-015021-pol2qm74	7323	7	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7323	8	and	and	CC
cord-015021-pol2qm74	7323	9	is	be	VBZ
cord-015021-pol2qm74	7323	10	termed	term	VBN
cord-015021-pol2qm74	7323	11	granulocyte	granulocyte	NN
cord-015021-pol2qm74	7323	12	colony	colony	NN
cord-015021-pol2qm74	7323	13	stimulating	stimulate	VBG
cord-015021-pol2qm74	7323	14	factor	factor	NN
cord-015021-pol2qm74	7323	15	(	(	-LRB-
cord-015021-pol2qm74	7323	16	G	G	NNP
cord-015021-pol2qm74	7323	17	-	-	HYPH
cord-015021-pol2qm74	7323	18	CSF	CSF	NNP
cord-015021-pol2qm74	7323	19	)	)	-RRB-
cord-015021-pol2qm74	7323	20	.	.	.
cord-015021-pol2qm74	7324	1	In	in	IN
cord-015021-pol2qm74	7324	2	the	the	DT
cord-015021-pol2qm74	7324	3	studies	study	NNS
cord-015021-pol2qm74	7324	4	to	to	TO
cord-015021-pol2qm74	7324	5	be	be	VB
cord-015021-pol2qm74	7324	6	discussed	discuss	VBN
cord-015021-pol2qm74	7324	7	,	,	,
cord-015021-pol2qm74	7324	8	we	-PRON-	PRP
cord-015021-pol2qm74	7324	9	have	have	VBP
cord-015021-pol2qm74	7324	10	attempted	attempt	VBN
cord-015021-pol2qm74	7324	11	to	to	TO
cord-015021-pol2qm74	7324	12	impact	impact	VB
cord-015021-pol2qm74	7324	13	hematopoiesis	hematopoiesis	NN
cord-015021-pol2qm74	7324	14	in	in	IN
cord-015021-pol2qm74	7324	15	the	the	DT
cord-015021-pol2qm74	7324	16	fetus	fetus	NN
cord-015021-pol2qm74	7324	17	using	use	VBG
cord-015021-pol2qm74	7324	18	exogenous	exogenous	JJ
cord-015021-pol2qm74	7324	19	rhG	rhG	NNP
cord-015021-pol2qm74	7324	20	-	-	HYPH
cord-015021-pol2qm74	7324	21	CSF	csf	NN
cord-015021-pol2qm74	7324	22	delivered	deliver	VBD
cord-015021-pol2qm74	7324	23	through	through	IN
cord-015021-pol2qm74	7324	24	the	the	DT
cord-015021-pol2qm74	7324	25	pregnant	pregnant	JJ
cord-015021-pol2qm74	7324	26	dam	dam	NN
cord-015021-pol2qm74	7324	27	.	.	.
cord-015021-pol2qm74	7325	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	7325	2	rationale	rationale	NN
cord-015021-pol2qm74	7325	3	was	be	VBD
cord-015021-pol2qm74	7325	4	that	that	IN
cord-015021-pol2qm74	7325	5	an	an	DT
cord-015021-pol2qm74	7325	6	enhanced	enhanced	JJ
cord-015021-pol2qm74	7325	7	myeloid	myeloid	NN
cord-015021-pol2qm74	7325	8	system	system	NN
cord-015021-pol2qm74	7325	9	may	may	MD
cord-015021-pol2qm74	7325	10	result	result	VB
cord-015021-pol2qm74	7325	11	from	from	IN
cord-015021-pol2qm74	7325	12	such	such	JJ
cord-015021-pol2qm74	7325	13	in	in	IN
cord-015021-pol2qm74	7325	14	utero	utero	NN
cord-015021-pol2qm74	7325	15	treatment	treatment	NN
cord-015021-pol2qm74	7325	16	leading	lead	VBG
cord-015021-pol2qm74	7325	17	to	to	IN
cord-015021-pol2qm74	7325	18	,	,	,
cord-015021-pol2qm74	7325	19	perhaps	perhaps	RB
cord-015021-pol2qm74	7325	20	,	,	,
cord-015021-pol2qm74	7325	21	enhanced	enhanced	JJ
cord-015021-pol2qm74	7325	22	protection	protection	NN
cord-015021-pol2qm74	7325	23	to	to	IN
cord-015021-pol2qm74	7325	24	microbial	microbial	JJ
cord-015021-pol2qm74	7325	25	insult	insult	NN
cord-015021-pol2qm74	7325	26	.	.	.
cord-015021-pol2qm74	7326	1	RhG	RhG	NNP
cord-015021-pol2qm74	7326	2	-	-	HYPH
cord-015021-pol2qm74	7326	3	CSF	CSF	NNP
cord-015021-pol2qm74	7326	4	crossed	cross	VBD
cord-015021-pol2qm74	7326	5	the	the	DT
cord-015021-pol2qm74	7326	6	placenta	placenta	NN
cord-015021-pol2qm74	7326	7	and	and	CC
cord-015021-pol2qm74	7326	8	reached	reach	VBN
cord-015021-pol2qm74	7326	9	peak	peak	JJ
cord-015021-pol2qm74	7326	10	fetal	fetal	JJ
cord-015021-pol2qm74	7326	11	serum	serum	NN
cord-015021-pol2qm74	7326	12	concentrations	concentration	NNS
cord-015021-pol2qm74	7326	13	4	4	CD
cord-015021-pol2qm74	7326	14	hours	hour	NNS
cord-015021-pol2qm74	7326	15	after	after	IN
cord-015021-pol2qm74	7326	16	administration	administration	NN
cord-015021-pol2qm74	7326	17	.	.	.
cord-015021-pol2qm74	7327	1	These	these	DT
cord-015021-pol2qm74	7327	2	levels	level	NNS
cord-015021-pol2qm74	7327	3	were	be	VBD
cord-015021-pol2qm74	7327	4	1000-fold	1000-fold	CD
cord-015021-pol2qm74	7327	5	lower	low	JJR
cord-015021-pol2qm74	7327	6	than	than	IN
cord-015021-pol2qm74	7327	7	the	the	DT
cord-015021-pol2qm74	7327	8	levels	level	NNS
cord-015021-pol2qm74	7327	9	detected	detect	VBN
cord-015021-pol2qm74	7327	10	in	in	IN
cord-015021-pol2qm74	7327	11	the	the	DT
cord-015021-pol2qm74	7327	12	adult	adult	NN
cord-015021-pol2qm74	7327	13	dams	dam	NNS
cord-015021-pol2qm74	7327	14	serum	serum	NN
cord-015021-pol2qm74	7327	15	.	.	.
cord-015021-pol2qm74	7328	1	White	white	JJ
cord-015021-pol2qm74	7328	2	blood	blood	NN
cord-015021-pol2qm74	7328	3	cell	cell	NN
cord-015021-pol2qm74	7328	4	counts	count	NNS
cord-015021-pol2qm74	7328	5	were	be	VBD
cord-015021-pol2qm74	7328	6	elevated	elevate	VBN
cord-015021-pol2qm74	7328	7	approximately	approximately	RB
cord-015021-pol2qm74	7328	8	2	2	CD
cord-015021-pol2qm74	7328	9	-	-	HYPH
cord-015021-pol2qm74	7328	10	4-fold	4-fold	CD
cord-015021-pol2qm74	7328	11	over	over	IN
cord-015021-pol2qm74	7328	12	control	control	NN
cord-015021-pol2qm74	7328	13	newborn	newborn	JJ
cord-015021-pol2qm74	7328	14	blood	blood	NN
cord-015021-pol2qm74	7328	15	.	.	.
cord-015021-pol2qm74	7329	1	This	this	DT
cord-015021-pol2qm74	7329	2	increase	increase	NN
cord-015021-pol2qm74	7329	3	was	be	VBD
cord-015021-pol2qm74	7329	4	due	due	JJ
cord-015021-pol2qm74	7329	5	to	to	IN
cord-015021-pol2qm74	7329	6	circulating	circulate	VBG
cord-015021-pol2qm74	7329	7	numbers	number	NNS
cord-015021-pol2qm74	7329	8	of	of	IN
cord-015021-pol2qm74	7329	9	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7329	10	.	.	.
cord-015021-pol2qm74	7330	1	The	the	DT
cord-015021-pol2qm74	7330	2	marrows	marrow	NNS
cord-015021-pol2qm74	7330	3	from	from	IN
cord-015021-pol2qm74	7330	4	these	these	DT
cord-015021-pol2qm74	7330	5	pups	pup	NNS
cord-015021-pol2qm74	7330	6	were	be	VBD
cord-015021-pol2qm74	7330	7	hyperplastic	hyperplastic	JJ
cord-015021-pol2qm74	7330	8	consisting	consist	VBG
cord-015021-pol2qm74	7330	9	of	of	IN
cord-015021-pol2qm74	7330	10	predominately	predominately	RB
cord-015021-pol2qm74	7330	11	immature	immature	JJ
cord-015021-pol2qm74	7330	12	and	and	CC
cord-015021-pol2qm74	7330	13	mature	mature	JJ
cord-015021-pol2qm74	7330	14	neutrophilic	neutrophilic	JJ
cord-015021-pol2qm74	7330	15	cells	cell	NNS
cord-015021-pol2qm74	7330	16	.	.	.
cord-015021-pol2qm74	7331	1	No	no	DT
cord-015021-pol2qm74	7331	2	changes	change	NNS
cord-015021-pol2qm74	7331	3	were	be	VBD
cord-015021-pol2qm74	7331	4	seen	see	VBN
cord-015021-pol2qm74	7331	5	in	in	IN
cord-015021-pol2qm74	7331	6	the	the	DT
cord-015021-pol2qm74	7331	7	thymus	thymus	NN
cord-015021-pol2qm74	7331	8	or	or	CC
cord-015021-pol2qm74	7331	9	livers	liver	NNS
cord-015021-pol2qm74	7331	10	.	.	.
cord-015021-pol2qm74	7332	1	Pups	pup	NNS
cord-015021-pol2qm74	7332	2	born	bear	VBN
cord-015021-pol2qm74	7332	3	to	to	IN
cord-015021-pol2qm74	7332	4	mothers	mother	NNS
cord-015021-pol2qm74	7332	5	treated	treat	VBN
cord-015021-pol2qm74	7332	6	with	with	IN
cord-015021-pol2qm74	7332	7	rhG	rhG	NNP
cord-015021-pol2qm74	7332	8	-	-	HYPH
cord-015021-pol2qm74	7332	9	CSF	CSF	NNP
cord-015021-pol2qm74	7332	10	since	since	IN
cord-015021-pol2qm74	7332	11	day	day	NN
cord-015021-pol2qm74	7332	12	15	15	CD
cord-015021-pol2qm74	7332	13	of	of	IN
cord-015021-pol2qm74	7332	14	gestation	gestation	NN
cord-015021-pol2qm74	7332	15	(	(	-LRB-
cord-015021-pol2qm74	7332	16	parturition	parturition	NN
cord-015021-pol2qm74	7332	17	in	in	IN
cord-015021-pol2qm74	7332	18	rodents	rodent	NNS
cord-015021-pol2qm74	7332	19	occurs	occur	VBZ
cord-015021-pol2qm74	7332	20	on	on	IN
cord-015021-pol2qm74	7332	21	approximately	approximately	RB
cord-015021-pol2qm74	7332	22	day	day	NN
cord-015021-pol2qm74	7332	23	21	21	CD
cord-015021-pol2qm74	7332	24	)	)	-RRB-
cord-015021-pol2qm74	7332	25	survived	survive	VBD
cord-015021-pol2qm74	7332	26	a	a	DT
cord-015021-pol2qm74	7332	27	lethal	lethal	JJ
cord-015021-pol2qm74	7332	28	challenge	challenge	NN
cord-015021-pol2qm74	7332	29	of	of	IN
cord-015021-pol2qm74	7332	30	group	group	NN
cord-015021-pol2qm74	7332	31	B-13	b-13	NN
cord-015021-pol2qm74	7332	32	hemolytic	hemolytic	JJ
cord-015021-pol2qm74	7332	33	Streptococcus	streptococcus	NN
cord-015021-pol2qm74	7332	34	.	.	.
cord-015021-pol2qm74	7333	1	In	in	IN
cord-015021-pol2qm74	7333	2	contrast	contrast	NN
cord-015021-pol2qm74	7333	3	their	-PRON-	PRP$
cord-015021-pol2qm74	7333	4	untreated	untreated	JJ
cord-015021-pol2qm74	7333	5	yet	yet	CC
cord-015021-pol2qm74	7333	6	infected	infect	VBN
cord-015021-pol2qm74	7333	7	counterparts	counterpart	NNS
cord-015021-pol2qm74	7333	8	did	do	VBD
cord-015021-pol2qm74	7333	9	not	not	RB
cord-015021-pol2qm74	7333	10	survive	survive	VB
cord-015021-pol2qm74	7333	11	.	.	.
cord-015021-pol2qm74	7334	1	Recent	recent	JJ
cord-015021-pol2qm74	7334	2	clinical	clinical	JJ
cord-015021-pol2qm74	7334	3	developments	development	NNS
cord-015021-pol2qm74	7334	4	have	have	VBP
cord-015021-pol2qm74	7334	5	led	lead	VBN
cord-015021-pol2qm74	7334	6	to	to	IN
cord-015021-pol2qm74	7334	7	trials	trial	NNS
cord-015021-pol2qm74	7334	8	of	of	IN
cord-015021-pol2qm74	7334	9	rhG	rhG	NNP
cord-015021-pol2qm74	7334	10	-	-	HYPH
cord-015021-pol2qm74	7334	11	CSF	csf	NN
cord-015021-pol2qm74	7334	12	in	in	IN
cord-015021-pol2qm74	7334	13	certain	certain	JJ
cord-015021-pol2qm74	7334	14	neutropenic	neutropenic	JJ
cord-015021-pol2qm74	7334	15	states	state	NNS
cord-015021-pol2qm74	7334	16	including	include	VBG
cord-015021-pol2qm74	7334	17	cyclic	cyclic	JJ
cord-015021-pol2qm74	7334	18	and	and	CC
cord-015021-pol2qm74	7334	19	chronic	chronic	JJ
cord-015021-pol2qm74	7334	20	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7334	21	.	.	.
cord-015021-pol2qm74	7335	1	We	-PRON-	PRP
cord-015021-pol2qm74	7335	2	have	have	VBP
cord-015021-pol2qm74	7335	3	identified	identify	VBN
cord-015021-pol2qm74	7335	4	several	several	JJ
cord-015021-pol2qm74	7335	5	of	of	IN
cord-015021-pol2qm74	7335	6	these	these	DT
cord-015021-pol2qm74	7335	7	patients	patient	NNS
cord-015021-pol2qm74	7335	8	who	who	WP
cord-015021-pol2qm74	7335	9	were	be	VBD
cord-015021-pol2qm74	7335	10	pregnant	pregnant	JJ
cord-015021-pol2qm74	7335	11	during	during	IN
cord-015021-pol2qm74	7335	12	treatment	treatment	NN
cord-015021-pol2qm74	7335	13	with	with	IN
cord-015021-pol2qm74	7335	14	rhG	rhG	NNP
cord-015021-pol2qm74	7335	15	-	-	HYPH
cord-015021-pol2qm74	7335	16	CSF	csf	NN
cord-015021-pol2qm74	7335	17	.	.	.
cord-015021-pol2qm74	7336	1	Biologically	biologically	RB
cord-015021-pol2qm74	7336	2	and	and	CC
cord-015021-pol2qm74	7336	3	anfigenically	anfigenically	RB
cord-015021-pol2qm74	7336	4	identifiable	identifiable	JJ
cord-015021-pol2qm74	7336	5	rhG	rhg	CD
cord-015021-pol2qm74	7336	6	-	-	HYPH
cord-015021-pol2qm74	7336	7	CSF	CSF	NNP
cord-015021-pol2qm74	7336	8	was	be	VBD
cord-015021-pol2qm74	7336	9	detected	detect	VBN
cord-015021-pol2qm74	7336	10	at	at	IN
cord-015021-pol2qm74	7336	11	increased	increase	VBN
cord-015021-pol2qm74	7336	12	levels	level	NNS
cord-015021-pol2qm74	7336	13	in	in	IN
cord-015021-pol2qm74	7336	14	the	the	DT
cord-015021-pol2qm74	7336	15	cord	cord	NN
cord-015021-pol2qm74	7336	16	serum	serum	NN
cord-015021-pol2qm74	7336	17	of	of	IN
cord-015021-pol2qm74	7336	18	these	these	DT
cord-015021-pol2qm74	7336	19	neonates	neonate	NNS
cord-015021-pol2qm74	7336	20	.	.	.
cord-015021-pol2qm74	7337	1	We	-PRON-	PRP
cord-015021-pol2qm74	7337	2	will	will	MD
cord-015021-pol2qm74	7337	3	discuss	discuss	VB
cord-015021-pol2qm74	7337	4	our	-PRON-	PRP$
cord-015021-pol2qm74	7337	5	findings	finding	NNS
cord-015021-pol2qm74	7337	6	with	with	IN
cord-015021-pol2qm74	7337	7	these	these	DT
cord-015021-pol2qm74	7337	8	patients	patient	NNS
cord-015021-pol2qm74	7337	9	in	in	IN
cord-015021-pol2qm74	7337	10	light	light	NN
cord-015021-pol2qm74	7337	11	of	of	IN
cord-015021-pol2qm74	7337	12	our	-PRON-	PRP$
cord-015021-pol2qm74	7337	13	animal	animal	NN
cord-015021-pol2qm74	7337	14	model	model	NN
cord-015021-pol2qm74	7337	15	of	of	IN
cord-015021-pol2qm74	7337	16	neonatal	neonatal	JJ
cord-015021-pol2qm74	7337	17	myeloid	myeloid	NN
cord-015021-pol2qm74	7337	18	development	development	NN
cord-015021-pol2qm74	7337	19	.	.	.
cord-015021-pol2qm74	7338	1	We	-PRON-	PRP
cord-015021-pol2qm74	7338	2	have	have	VBP
cord-015021-pol2qm74	7338	3	previously	previously	RB
cord-015021-pol2qm74	7338	4	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7338	5	decreased	decrease	VBD
cord-015021-pol2qm74	7338	6	G	G	NNP
cord-015021-pol2qm74	7338	7	-	-	HYPH
cord-015021-pol2qm74	7338	8	CSF	csf	NN
cord-015021-pol2qm74	7338	9	production	production	NN
cord-015021-pol2qm74	7338	10	and	and	CC
cord-015021-pol2qm74	7338	11	G	G	NNP
cord-015021-pol2qm74	7338	12	-	-	HYPH
cord-015021-pol2qm74	7338	13	CSF	CSF	NNP
cord-015021-pol2qm74	7338	14	mRNA	mrna	NN
cord-015021-pol2qm74	7338	15	expression	expression	NN
cord-015021-pol2qm74	7338	16	from	from	IN
cord-015021-pol2qm74	7338	17	activated	activate	VBN
cord-015021-pol2qm74	7338	18	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	7338	19	cells	cell	NNS
cord-015021-pol2qm74	7338	20	from	from	IN
cord-015021-pol2qm74	7338	21	newboms	newboms	NN
cord-015021-pol2qm74	7338	22	compared	compare	VBN
cord-015021-pol2qm74	7338	23	to	to	IN
cord-015021-pol2qm74	7338	24	adults	adult	NNS
cord-015021-pol2qm74	7338	25	(	(	-LRB-
cord-015021-pol2qm74	7338	26	Cairo	Cairo	NNP
cord-015021-pol2qm74	7338	27	,	,	,
cord-015021-pol2qm74	7338	28	Pediatr	Pediatr	NNP
cord-015021-pol2qm74	7338	29	Res	Res	NNP
cord-015021-pol2qm74	7338	30	31:574	31:574	NN
cord-015021-pol2qm74	7338	31	,	,	,
cord-015021-pol2qm74	7338	32	1992	1992	CD
cord-015021-pol2qm74	7338	33	)	)	-RRB-
cord-015021-pol2qm74	7338	34	.	.	.
cord-015021-pol2qm74	7339	1	We	-PRON-	PRP
cord-015021-pol2qm74	7339	2	have	have	VBP
cord-015021-pol2qm74	7339	3	also	also	RB
cord-015021-pol2qm74	7339	4	recently	recently	RB
cord-015021-pol2qm74	7339	5	observed	observe	VBN
cord-015021-pol2qm74	7339	6	that	that	IN
cord-015021-pol2qm74	7339	7	administration	administration	NN
cord-015021-pol2qm74	7339	8	of	of	IN
cord-015021-pol2qm74	7339	9	a	a	DT
cord-015021-pol2qm74	7339	10	single	single	JJ
cord-015021-pol2qm74	7339	11	dose	dose	NN
cord-015021-pol2qm74	7339	12	of	of	IN
cord-015021-pol2qm74	7339	13	rhG	rhG	NNP
cord-015021-pol2qm74	7339	14	-	-	HYPH
cord-015021-pol2qm74	7339	15	CSE	CSE	NNP
cord-015021-pol2qm74	7339	16	to	to	IN
cord-015021-pol2qm74	7339	17	one	one	CD
cord-015021-pol2qm74	7339	18	-	-	HYPH
cord-015021-pol2qm74	7339	19	day	day	NN
cord-015021-pol2qm74	7339	20	-	-	HYPH
cord-015021-pol2qm74	7339	21	old	old	JJ
cord-015021-pol2qm74	7339	22	newborn	newborn	JJ
cord-015021-pol2qm74	7339	23	rats	rat	NNS
cord-015021-pol2qm74	7339	24	induced	induce	VBD
cord-015021-pol2qm74	7339	25	significant	significant	JJ
cord-015021-pol2qm74	7339	26	neatrophilia	neatrophilia	NNP
cord-015021-pol2qm74	7339	27	,	,	,
cord-015021-pol2qm74	7339	28	while	while	IN
cord-015021-pol2qm74	7339	29	administration	administration	NN
cord-015021-pol2qm74	7339	30	for	for	IN
cord-015021-pol2qm74	7339	31	7	7	CD
cord-015021-pol2qm74	7339	32	days	day	NNS
cord-015021-pol2qm74	7339	33	induced	induce	VBN
cord-015021-pol2qm74	7339	34	neulrophilia	neulrophilia	NNP
cord-015021-pol2qm74	7339	35	and	and	CC
cord-015021-pol2qm74	7339	36	increased	increase	VBD
cord-015021-pol2qm74	7339	37	the	the	DT
cord-015021-pol2qm74	7339	38	bone	bone	NN
cord-015021-pol2qm74	7339	39	marrow	marrow	NN
cord-015021-pol2qm74	7339	40	(	(	-LRB-
cord-015021-pol2qm74	7339	41	BM	BM	NNP
cord-015021-pol2qm74	7339	42	)	)	-RRB-
cord-015021-pol2qm74	7339	43	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7339	44	storage	storage	NN
cord-015021-pol2qm74	7339	45	and	and	CC
cord-015021-pol2qm74	7339	46	progenitor	progenitor	NN
cord-015021-pol2qm74	7339	47	pools	pool	NNS
cord-015021-pol2qm74	7340	1	(	(	-LRB-
cord-015021-pol2qm74	7340	2	Cairo	Cairo	NNP
cord-015021-pol2qm74	7340	3	,	,	,
cord-015021-pol2qm74	7340	4	Blood	blood	NN
cord-015021-pol2qm74	7340	5	76:1788	76:1788	CD
cord-015021-pol2qm74	7340	6	,	,	,
cord-015021-pol2qm74	7340	7	1990	1990	CD
cord-015021-pol2qm74	7340	8	Cairo	Cairo	NNP
cord-015021-pol2qm74	7340	9	,	,	,
cord-015021-pol2qm74	7340	10	Pediatr	Pediatr	NNP
cord-015021-pol2qm74	7340	11	Res	Res	NNP
cord-015021-pol2qm74	7340	12	27:612	27:612	CD
cord-015021-pol2qm74	7340	13	,	,	,
cord-015021-pol2qm74	7340	14	1990	1990	CD
cord-015021-pol2qm74	7340	15	)	)	-RRB-
cord-015021-pol2qm74	7340	16	.	.	.
cord-015021-pol2qm74	7341	1	We	-PRON-	PRP
cord-015021-pol2qm74	7341	2	embarked	embark	VBD
cord-015021-pol2qm74	7341	3	on	on	IN
cord-015021-pol2qm74	7341	4	a	a	DT
cord-015021-pol2qm74	7341	5	phase	phase	NN
cord-015021-pol2qm74	7341	6	I	-PRON-	PRP
cord-015021-pol2qm74	7341	7	trial	trial	NN
cord-015021-pol2qm74	7341	8	exploring	explore	VBG
cord-015021-pol2qm74	7341	9	the	the	DT
cord-015021-pol2qm74	7341	10	safety	safety	NN
cord-015021-pol2qm74	7341	11	,	,	,
cord-015021-pol2qm74	7341	12	pharmacokinetics	pharmacokinetic	NNS
cord-015021-pol2qm74	7341	13	,	,	,
cord-015021-pol2qm74	7341	14	and	and	CC
cord-015021-pol2qm74	7341	15	biological	biological	JJ
cord-015021-pol2qm74	7341	16	efficacy	efficacy	NN
cord-015021-pol2qm74	7341	17	of	of	IN
cord-015021-pol2qm74	7341	18	G	G	NNP
cord-015021-pol2qm74	7341	19	-	-	HYPH
cord-015021-pol2qm74	7341	20	CSF	CSF	NNP
cord-015021-pol2qm74	7341	21	in	in	IN
cord-015021-pol2qm74	7341	22	newborns	newborn	NNS
cord-015021-pol2qm74	7341	23	with	with	IN
cord-015021-pol2qm74	7341	24	presumed	presume	VBN
cord-015021-pol2qm74	7341	25	sepsis	sepsis	NN
cord-015021-pol2qm74	7341	26	.	.	.
cord-015021-pol2qm74	7342	1	42	42	CD
cord-015021-pol2qm74	7342	2	infants	infant	NNS
cord-015021-pol2qm74	7342	3	<	<	XX
cord-015021-pol2qm74	7342	4	72	72	CD
cord-015021-pol2qm74	7342	5	hrs	hrs	NN
cord-015021-pol2qm74	7342	6	old	old	JJ
cord-015021-pol2qm74	7342	7	with	with	IN
cord-015021-pol2qm74	7342	8	a	a	DT
cord-015021-pol2qm74	7342	9	diagnosis	diagnosis	NN
cord-015021-pol2qm74	7342	10	of	of	IN
cord-015021-pol2qm74	7342	11	presumed	presume	VBN
cord-015021-pol2qm74	7342	12	sepsis	sepsis	NN
cord-015021-pol2qm74	7342	13	were	be	VBD
cord-015021-pol2qm74	7342	14	stratified	stratify	VBN
cord-015021-pol2qm74	7342	15	into	into	IN
cord-015021-pol2qm74	7342	16	three	three	CD
cord-015021-pol2qm74	7342	17	groups	group	NNS
cord-015021-pol2qm74	7342	18	:	:	:
cord-015021-pol2qm74	7342	19	very	very	RB
cord-015021-pol2qm74	7342	20	preterm	preterm	JJ
cord-015021-pol2qm74	7342	21	(	(	-LRB-
cord-015021-pol2qm74	7342	22	26	26	CD
cord-015021-pol2qm74	7342	23	-	-	SYM
cord-015021-pol2qm74	7342	24	30	30	CD
cord-015021-pol2qm74	7342	25	wk	wk	NN
cord-015021-pol2qm74	7342	26	)	)	-RRB-
cord-015021-pol2qm74	7342	27	,	,	,
cord-015021-pol2qm74	7342	28	preterm	preterm	NNS
cord-015021-pol2qm74	7342	29	(	(	-LRB-
cord-015021-pol2qm74	7342	30	31	31	CD
cord-015021-pol2qm74	7342	31	-	-	SYM
cord-015021-pol2qm74	7342	32	35	35	CD
cord-015021-pol2qm74	7342	33	wk	wk	NNS
cord-015021-pol2qm74	7342	34	)	)	-RRB-
cord-015021-pol2qm74	7342	35	,	,	,
cord-015021-pol2qm74	7342	36	and	and	CC
cord-015021-pol2qm74	7342	37	term	term	NN
cord-015021-pol2qm74	7342	38	(	(	-LRB-
cord-015021-pol2qm74	7342	39	>	>	NFP
cord-015021-pol2qm74	7342	40	36	36	CD
cord-015021-pol2qm74	7342	41	wk	wk	NN
cord-015021-pol2qm74	7342	42	)	)	-RRB-
cord-015021-pol2qm74	7342	43	and	and	CC
cord-015021-pol2qm74	7342	44	randomized	randomize	VBD
cord-015021-pol2qm74	7342	45	to	to	TO
cord-015021-pol2qm74	7342	46	receive	receive	VB
cord-015021-pol2qm74	7342	47	either	either	CC
cord-015021-pol2qm74	7342	48	a	a	DT
cord-015021-pol2qm74	7342	49	placebo	placebo	NN
cord-015021-pol2qm74	7342	50	or	or	CC
cord-015021-pol2qm74	7342	51	1	1	CD
cord-015021-pol2qm74	7342	52	,	,	,
cord-015021-pol2qm74	7342	53	5	5	CD
cord-015021-pol2qm74	7342	54	,	,	,
cord-015021-pol2qm74	7342	55	and	and	CC
cord-015021-pol2qm74	7342	56	10	10	CD
cord-015021-pol2qm74	7342	57	gg	gg	NNP
cord-015021-pol2qm74	7342	58	/	/	SYM
cord-015021-pol2qm74	7342	59	kg	kg	NNP
cord-015021-pol2qm74	7342	60	/	/	SYM
cord-015021-pol2qm74	7342	61	qd	qd	NN
cord-015021-pol2qm74	7342	62	or	or	CC
cord-015021-pol2qm74	7342	63	5	5	CD
cord-015021-pol2qm74	7342	64	and	and	CC
cord-015021-pol2qm74	7342	65	10	10	CD
cord-015021-pol2qm74	7343	1	p.g	p.g	NNP
cord-015021-pol2qm74	7343	2	/	/	SYM
cord-015021-pol2qm74	7343	3	kg	kg	NNP
cord-015021-pol2qm74	7343	4	/	/	SYM
cord-015021-pol2qm74	7343	5	bid	bid	NN
cord-015021-pol2qm74	7343	6	of	of	IN
cord-015021-pol2qm74	7343	7	rhG	rhG	NNP
cord-015021-pol2qm74	7343	8	-	-	HYPH
cord-015021-pol2qm74	7343	9	CSF	csf	NN
cord-015021-pol2qm74	7343	10	infused	infuse	VBN
cord-015021-pol2qm74	7343	11	by	by	IN
cord-015021-pol2qm74	7343	12	pump	pump	NN
cord-015021-pol2qm74	7343	13	over	over	IN
cord-015021-pol2qm74	7343	14	1	1	CD
cord-015021-pol2qm74	7343	15	hour	hour	NN
cord-015021-pol2qm74	7343	16	for	for	IN
cord-015021-pol2qm74	7343	17	3	3	CD
cord-015021-pol2qm74	7343	18	consecutive	consecutive	JJ
cord-015021-pol2qm74	7343	19	days	day	NNS
cord-015021-pol2qm74	7343	20	.	.	.
cord-015021-pol2qm74	7344	1	CBCs	cbc	NNS
cord-015021-pol2qm74	7344	2	were	be	VBD
cord-015021-pol2qm74	7344	3	obtained	obtain	VBN
cord-015021-pol2qm74	7344	4	at	at	IN
cord-015021-pol2qm74	7344	5	2	2	CD
cord-015021-pol2qm74	7344	6	,	,	,
cord-015021-pol2qm74	7344	7	6	6	CD
cord-015021-pol2qm74	7344	8	,	,	,
cord-015021-pol2qm74	7344	9	24	24	CD
cord-015021-pol2qm74	7344	10	,	,	,
cord-015021-pol2qm74	7344	11	48	48	CD
cord-015021-pol2qm74	7344	12	,	,	,
cord-015021-pol2qm74	7344	13	72	72	CD
cord-015021-pol2qm74	7344	14	and	and	CC
cord-015021-pol2qm74	7344	15	96	96	CD
cord-015021-pol2qm74	7344	16	hrs	hrs	NN
cord-015021-pol2qm74	7344	17	.	.	.
cord-015021-pol2qm74	7345	1	Tibial	tibial	JJ
cord-015021-pol2qm74	7345	2	bone	bone	NN
cord-015021-pol2qm74	7345	3	marrow	marrow	NN
cord-015021-pol2qm74	7345	4	aspirations	aspiration	NNS
cord-015021-pol2qm74	7345	5	were	be	VBD
cord-015021-pol2qm74	7345	6	performed	perform	VBN
cord-015021-pol2qm74	7345	7	72	72	CD
cord-015021-pol2qm74	7345	8	hrs	hrs	NN
cord-015021-pol2qm74	7345	9	after	after	IN
cord-015021-pol2qm74	7345	10	study	study	NN
cord-015021-pol2qm74	7345	11	entry	entry	NN
cord-015021-pol2qm74	7345	12	and	and	CC
cord-015021-pol2qm74	7345	13	differential	differential	JJ
cord-015021-pol2qm74	7345	14	counts	count	NNS
cord-015021-pol2qm74	7345	15	and	and	CC
cord-015021-pol2qm74	7345	16	CFU	CFU	NNP
cord-015021-pol2qm74	7345	17	-	-	HYPH
cord-015021-pol2qm74	7345	18	GM	GM	NNP
cord-015021-pol2qm74	7345	19	pools	pool	NNS
cord-015021-pol2qm74	7345	20	were	be	VBD
cord-015021-pol2qm74	7345	21	determined	determine	VBN
cord-015021-pol2qm74	7345	22	.	.	.
cord-015021-pol2qm74	7346	1	C3bi	C3bi	NNP
cord-015021-pol2qm74	7346	2	expression	expression	NN
cord-015021-pol2qm74	7346	3	was	be	VBD
cord-015021-pol2qm74	7346	4	determined	determine	VBN
cord-015021-pol2qm74	7346	5	at	at	IN
cord-015021-pol2qm74	7346	6	0	0	CD
cord-015021-pol2qm74	7346	7	and	and	CC
cord-015021-pol2qm74	7346	8	24	24	CD
cord-015021-pol2qm74	7346	9	hrs	hrs	NN
cord-015021-pol2qm74	7346	10	after	after	IN
cord-015021-pol2qm74	7346	11	rhG	rhG	NNP
cord-015021-pol2qm74	7346	12	-	-	HYPH
cord-015021-pol2qm74	7346	13	CSF	CSF	NNP
cord-015021-pol2qm74	7346	14	,	,	,
cord-015021-pol2qm74	7346	15	and	and	CC
cord-015021-pol2qm74	7346	16	G	G	NNP
cord-015021-pol2qm74	7346	17	-	-	HYPH
cord-015021-pol2qm74	7346	18	CSF	csf	NN
cord-015021-pol2qm74	7346	19	pharmacokinetics	pharmacokinetic	NNS
cord-015021-pol2qm74	7346	20	were	be	VBD
cord-015021-pol2qm74	7346	21	performed	perform	VBN
cord-015021-pol2qm74	7346	22	after	after	IN
cord-015021-pol2qm74	7346	23	the	the	DT
cord-015021-pol2qm74	7346	24	first	first	JJ
cord-015021-pol2qm74	7346	25	dose	dose	NN
cord-015021-pol2qm74	7346	26	of	of	IN
cord-015021-pol2qm74	7346	27	rhG	rhG	NNP
cord-015021-pol2qm74	7346	28	-	-	HYPH
cord-015021-pol2qm74	7346	29	CSF	csf	NN
cord-015021-pol2qm74	7346	30	utilizing	utilize	VBG
cord-015021-pol2qm74	7346	31	a	a	DT
cord-015021-pol2qm74	7346	32	sandwich	sandwich	NN
cord-015021-pol2qm74	7346	33	ELISA	ELISA	NNP
cord-015021-pol2qm74	7346	34	.	.	.
cord-015021-pol2qm74	7347	1	A	a	DT
cord-015021-pol2qm74	7347	2	significant	significant	JJ
cord-015021-pol2qm74	7347	3	increase	increase	NN
cord-015021-pol2qm74	7347	4	in	in	IN
cord-015021-pol2qm74	7347	5	the	the	DT
cord-015021-pol2qm74	7347	6	ANC	ANC	NNP
cord-015021-pol2qm74	7347	7	was	be	VBD
cord-015021-pol2qm74	7347	8	observed	observe	VBN
cord-015021-pol2qm74	7347	9	at	at	IN
cord-015021-pol2qm74	7347	10	48	48	CD
cord-015021-pol2qm74	7347	11	,	,	,
cord-015021-pol2qm74	7347	12	72	72	CD
cord-015021-pol2qm74	7347	13	and	and	CC
cord-015021-pol2qm74	7347	14	96	96	CD
cord-015021-pol2qm74	7347	15	hrs	hrs	NN
cord-015021-pol2qm74	7347	16	following	follow	VBG
cord-015021-pol2qm74	7347	17	administration	administration	NN
cord-015021-pol2qm74	7347	18	of	of	IN
cord-015021-pol2qm74	7347	19	both	both	DT
cord-015021-pol2qm74	7347	20	5	5	CD
cord-015021-pol2qm74	7347	21	and	and	CC
cord-015021-pol2qm74	7347	22	10	10	CD
cord-015021-pol2qm74	7348	1	~tg	~tg	NNP
cord-015021-pol2qm74	7348	2	/	/	SYM
cord-015021-pol2qm74	7348	3	kg	kg	NN
cord-015021-pol2qm74	7348	4	/	/	SYM
cord-015021-pol2qm74	7348	5	d	d	NN
cord-015021-pol2qm74	7348	6	of	of	IN
cord-015021-pol2qm74	7348	7	rhG	rhG	NNP
cord-015021-pol2qm74	7348	8	-	-	HYPH
cord-015021-pol2qm74	7348	9	CSF	CSF	NNP
cord-015021-pol2qm74	7348	10	.	.	.
cord-015021-pol2qm74	7349	1	The	the	DT
cord-015021-pol2qm74	7349	2	maximum	maximum	JJ
cord-015021-pol2qm74	7349	3	increase	increase	NN
cord-015021-pol2qm74	7349	4	in	in	IN
cord-015021-pol2qm74	7349	5	the	the	DT
cord-015021-pol2qm74	7349	6	ANC	ANC	NNP
cord-015021-pol2qm74	7349	7	occurred	occur	VBD
cord-015021-pol2qm74	7349	8	72	72	CD
cord-015021-pol2qm74	7349	9	hrs	hrs	NN
cord-015021-pol2qm74	7349	10	after	after	IN
cord-015021-pol2qm74	7349	11	5	5	CD
cord-015021-pol2qm74	7349	12	and	and	CC
cord-015021-pol2qm74	7349	13	10	10	CD
cord-015021-pol2qm74	7349	14	~tg	~tg	NNS
cord-015021-pol2qm74	7350	1	/kg	/kg	NFP
cord-015021-pol2qm74	7350	2	/	/	SYM
cord-015021-pol2qm74	7350	3	d	d	NN
cord-015021-pol2qm74	7350	4	(	(	-LRB-
cord-015021-pol2qm74	7350	5	397	397	CD
cord-015021-pol2qm74	7350	6	-116	-116	NN
cord-015021-pol2qm74	7350	7	%	%	NN
cord-015021-pol2qm74	7350	8	)	)	-RRB-
cord-015021-pol2qm74	7350	9	(	(	-LRB-
cord-015021-pol2qm74	7350	10	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	7350	11	)	)	-RRB-
cord-015021-pol2qm74	7350	12	and	and	CC
cord-015021-pol2qm74	7350	13	(	(	-LRB-
cord-015021-pol2qm74	7350	14	621	621	CD
cord-015021-pol2qm74	7350	15	%	%	NN
cord-015021-pol2qm74	7350	16	-+	-+	.
cord-015021-pol2qm74	7350	17	200	200	CD
cord-015021-pol2qm74	7350	18	%	%	NN
cord-015021-pol2qm74	7350	19	)	)	-RRB-
cord-015021-pol2qm74	7350	20	(	(	-LRB-
cord-015021-pol2qm74	7350	21	p<0.001	p<0.001	JJ
cord-015021-pol2qm74	7350	22	)	)	-RRB-
cord-015021-pol2qm74	7350	23	,	,	,
cord-015021-pol2qm74	7350	24	respectively	respectively	RB
cord-015021-pol2qm74	7350	25	.	.	.
cord-015021-pol2qm74	7351	1	There	there	EX
cord-015021-pol2qm74	7351	2	was	be	VBD
cord-015021-pol2qm74	7351	3	a	a	DT
cord-015021-pol2qm74	7351	4	significant	significant	JJ
cord-015021-pol2qm74	7351	5	dose	dose	NN
cord-015021-pol2qm74	7351	6	-	-	HYPH
cord-015021-pol2qm74	7351	7	dapendeat	dapendeat	NN
cord-015021-pol2qm74	7351	8	increase	increase	NN
cord-015021-pol2qm74	7351	9	in	in	IN
cord-015021-pol2qm74	7351	10	the	the	DT
cord-015021-pol2qm74	7351	11	BM	BM	NNP
cord-015021-pol2qm74	7351	12	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7351	13	storage	storage	NN
cord-015021-pol2qm74	7351	14	pool	pool	NN
cord-015021-pol2qm74	7351	15	(	(	-LRB-
cord-015021-pol2qm74	7351	16	18	18	CD
cord-015021-pol2qm74	7351	17	_	_	NN
cord-015021-pol2qm74	7351	18	+	+	SYM
cord-015021-pol2qm74	7351	19	4	4	CD
cord-015021-pol2qm74	7351	20	%	%	NN
cord-015021-pol2qm74	7351	21	vs.	vs.	CC
cord-015021-pol2qm74	7351	22	62	62	CD
cord-015021-pol2qm74	7351	23	+	+	SYM
cord-015021-pol2qm74	7351	24	6	6	CD
cord-015021-pol2qm74	7351	25	%	%	NN
cord-015021-pol2qm74	7351	26	)	)	-RRB-
cord-015021-pol2qm74	7351	27	(	(	-LRB-
cord-015021-pol2qm74	7351	28	p<0.01	p<0.01	NN
cord-015021-pol2qm74	7351	29	)	)	-RRB-
cord-015021-pol2qm74	7352	1	(	(	-LRB-
cord-015021-pol2qm74	7352	2	placebo	placebo	NN
cord-015021-pol2qm74	7352	3	vs.	vs.	IN
cord-015021-pol2qm74	7352	4	10	10	CD
cord-015021-pol2qm74	7353	1	~tg	~tg	NNP
cord-015021-pol2qm74	7353	2	/	/	SYM
cord-015021-pol2qm74	7353	3	kg	kg	NN
cord-015021-pol2qm74	7353	4	/	/	SYM
cord-015021-pol2qm74	7353	5	d	d	NN
cord-015021-pol2qm74	7353	6	)	)	-RRB-
cord-015021-pol2qm74	7353	7	.	.	.
cord-015021-pol2qm74	7354	1	There	there	EX
cord-015021-pol2qm74	7354	2	was	be	VBD
cord-015021-pol2qm74	7354	3	no	no	DT
cord-015021-pol2qm74	7354	4	significant	significant	JJ
cord-015021-pol2qm74	7354	5	difference	difference	NN
cord-015021-pol2qm74	7354	6	in	in	IN
cord-015021-pol2qm74	7354	7	the	the	DT
cord-015021-pol2qm74	7354	8	nantrophil	nantrophil	NNP
cord-015021-pol2qm74	7354	9	proliferative	proliferative	JJ
cord-015021-pol2qm74	7354	10	pool	pool	NN
cord-015021-pol2qm74	7354	11	.	.	.
cord-015021-pol2qm74	7355	1	An	an	DT
cord-015021-pol2qm74	7355	2	increase	increase	NN
cord-015021-pol2qm74	7355	3	in	in	IN
cord-015021-pol2qm74	7355	4	CFU	CFU	NNP
cord-015021-pol2qm74	7355	5	-	-	HYPH
cord-015021-pol2qm74	7355	6	GM	GM	NNP
cord-015021-pol2qm74	7355	7	and	and	CC
cord-015021-pol2qm74	7355	8	CFU	CFU	NNP
cord-015021-pol2qm74	7355	9	-	-	HYPH
cord-015021-pol2qm74	7355	10	GEMM	GEMM	NNP
cord-015021-pol2qm74	7355	11	was	be	VBD
cord-015021-pol2qm74	7355	12	seen	see	VBN
cord-015021-pol2qm74	7355	13	at	at	IN
cord-015021-pol2qm74	7355	14	all	all	DT
cord-015021-pol2qm74	7355	15	doses	dose	NNS
cord-015021-pol2qm74	7355	16	tested	test	VBN
cord-015021-pol2qm74	7355	17	,	,	,
cord-015021-pol2qm74	7355	18	compared	compare	VBN
cord-015021-pol2qm74	7355	19	to	to	IN
cord-015021-pol2qm74	7355	20	placebo	placebo	NN
cord-015021-pol2qm74	7355	21	(	(	-LRB-
cord-015021-pol2qm74	7355	22	53.5	53.5	CD
cord-015021-pol2qm74	7355	23	_	_	NN
cord-015021-pol2qm74	7355	24	+	+	CC
cord-015021-pol2qm74	7356	1	8.6	8.6	CD
cord-015021-pol2qm74	7356	2	vs.	vs.	NN
cord-015021-pol2qm74	7356	3	87	87	CD
cord-015021-pol2qm74	7356	4	-+	-+	.
cord-015021-pol2qm74	7356	5	15	15	CD
cord-015021-pol2qm74	7356	6	)	)	-RRB-
cord-015021-pol2qm74	7356	7	(	(	-LRB-
cord-015021-pol2qm74	7356	8	colonies	colony	NNS
cord-015021-pol2qm74	7356	9	/	/	SYM
cord-015021-pol2qm74	7356	10	l(P	l(p	NN
cord-015021-pol2qm74	7356	11	cells	cell	NNS
cord-015021-pol2qm74	7356	12	/	/	SYM
cord-015021-pol2qm74	7356	13	plate	plate	NN
cord-015021-pol2qm74	7356	14	)	)	-RRB-
cord-015021-pol2qm74	7356	15	.	.	.
cord-015021-pol2qm74	7357	1	C3bi	C3bi	NNP
cord-015021-pol2qm74	7357	2	expression	expression	NN
cord-015021-pol2qm74	7357	3	was	be	VBD
cord-015021-pol2qm74	7357	4	significantly	significantly	RB
cord-015021-pol2qm74	7357	5	increased	increase	VBN
cord-015021-pol2qm74	7357	6	24	24	CD
cord-015021-pol2qm74	7357	7	hrs	hrs	NN
cord-015021-pol2qm74	7357	8	after	after	IN
cord-015021-pol2qm74	7357	9	10	10	CD
cord-015021-pol2qm74	7357	10	Bg	Bg	NNP
cord-015021-pol2qm74	7357	11	/	/	SYM
cord-015021-pol2qm74	7357	12	kg	kg	NN
cord-015021-pol2qm74	7357	13	/	/	SYM
cord-015021-pol2qm74	7357	14	d	d	NN
cord-015021-pol2qm74	7357	15	of	of	IN
cord-015021-pol2qm74	7357	16	rhG	rhG	NNP
cord-015021-pol2qm74	7357	17	-	-	HYPH
cord-015021-pol2qm74	7357	18	CSF	CSF	NNP
cord-015021-pol2qm74	7357	19	(	(	-LRB-
cord-015021-pol2qm74	7357	20	233	233	CD
cord-015021-pol2qm74	7357	21	+	+	SYM
cord-015021-pol2qm74	7357	22	81	81	CD
cord-015021-pol2qm74	7357	23	%	%	NN
cord-015021-pol2qm74	7357	24	vs.	vs.	CC
cord-015021-pol2qm74	7357	25	83	83	CD
cord-015021-pol2qm74	7357	26	+	+	SYM
cord-015021-pol2qm74	7357	27	-26	-26	CD
cord-015021-pol2qm74	7357	28	%	%	NN
cord-015021-pol2qm74	7357	29	)	)	-RRB-
cord-015021-pol2qm74	7358	1	(	(	-LRB-
cord-015021-pol2qm74	7358	2	p<0.012	p<0.012	NN
cord-015021-pol2qm74	7358	3	)	)	-RRB-
cord-015021-pol2qm74	7358	4	.	.	.
cord-015021-pol2qm74	7359	1	Peak	peak	NN
cord-015021-pol2qm74	7359	2	serum	serum	NN
cord-015021-pol2qm74	7359	3	G	G	NNP
cord-015021-pol2qm74	7359	4	-	-	HYPH
cord-015021-pol2qm74	7359	5	CSF	CSF	NNP
cord-015021-pol2qm74	7359	6	levels	level	NNS
cord-015021-pol2qm74	7359	7	occurred	occur	VBD
cord-015021-pol2qm74	7359	8	at	at	IN
cord-015021-pol2qm74	7359	9	2	2	CD
cord-015021-pol2qm74	7359	10	hrs	hrs	NN
cord-015021-pol2qm74	7359	11	and	and	CC
cord-015021-pol2qm74	7359	12	were	be	VBD
cord-015021-pol2qm74	7359	13	dosedependent	dosedependent	JJ
cord-015021-pol2qm74	7359	14	.	.	.
cord-015021-pol2qm74	7360	1	The	the	DT
cord-015021-pol2qm74	7360	2	half	half	JJ
cord-015021-pol2qm74	7360	3	-	-	HYPH
cord-015021-pol2qm74	7360	4	life	life	NN
cord-015021-pol2qm74	7360	5	of	of	IN
cord-015021-pol2qm74	7360	6	rhG	rhG	NNP
cord-015021-pol2qm74	7360	7	-	-	HYPH
cord-015021-pol2qm74	7360	8	CSE	CSE	NNP
cord-015021-pol2qm74	7360	9	was	be	VBD
cord-015021-pol2qm74	7360	10	4.44	4.44	CD
cord-015021-pol2qm74	7360	11	+	+	SYM
cord-015021-pol2qm74	7360	12	0.4	0.4	CD
cord-015021-pol2qm74	7360	13	hrs	hrs	NN
cord-015021-pol2qm74	7360	14	.	.	.
cord-015021-pol2qm74	7361	1	Most	most	RBS
cord-015021-pol2qm74	7361	2	importantly	importantly	RB
cord-015021-pol2qm74	7361	3	,	,	,
cord-015021-pol2qm74	7361	4	there	there	EX
cord-015021-pol2qm74	7361	5	was	be	VBD
cord-015021-pol2qm74	7361	6	no	no	DT
cord-015021-pol2qm74	7361	7	observed	observed	JJ
cord-015021-pol2qm74	7361	8	toxicity	toxicity	NN
cord-015021-pol2qm74	7361	9	from	from	IN
cord-015021-pol2qm74	7361	10	G	G	NNP
cord-015021-pol2qm74	7361	11	-	-	HYPH
cord-015021-pol2qm74	7361	12	CSF	CSF	NNP
cord-015021-pol2qm74	7361	13	in	in	IN
cord-015021-pol2qm74	7361	14	all	all	DT
cord-015021-pol2qm74	7361	15	patients	patient	NNS
cord-015021-pol2qm74	7361	16	studied	study	VBD
cord-015021-pol2qm74	7361	17	.	.	.
cord-015021-pol2qm74	7362	1	31	31	CD
cord-015021-pol2qm74	7362	2	of	of	IN
cord-015021-pol2qm74	7362	3	42	42	CD
cord-015021-pol2qm74	7362	4	patients	patient	NNS
cord-015021-pol2qm74	7362	5	were	be	VBD
cord-015021-pol2qm74	7362	6	on	on	IN
cord-015021-pol2qm74	7362	7	ventilators	ventilator	NNS
cord-015021-pol2qm74	7362	8	prior	prior	RB
cord-015021-pol2qm74	7362	9	to	to	IN
cord-015021-pol2qm74	7362	10	administration	administration	NN
cord-015021-pol2qm74	7362	11	of	of	IN
cord-015021-pol2qm74	7362	12	rhG	rhG	NNP
cord-015021-pol2qm74	7362	13	-	-	HYPH
cord-015021-pol2qm74	7362	14	CSF	CSF	NNP
cord-015021-pol2qm74	7362	15	and	and	CC
cord-015021-pol2qm74	7362	16	there	there	EX
cord-015021-pol2qm74	7362	17	was	be	VBD
cord-015021-pol2qm74	7362	18	no	no	DT
cord-015021-pol2qm74	7362	19	increase	increase	NN
cord-015021-pol2qm74	7362	20	in	in	IN
cord-015021-pol2qm74	7362	21	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7362	22	toxicity	toxicity	NN
cord-015021-pol2qm74	7362	23	.	.	.
cord-015021-pol2qm74	7363	1	These	these	DT
cord-015021-pol2qm74	7363	2	preliminary	preliminary	JJ
cord-015021-pol2qm74	7363	3	data	datum	NNS
cord-015021-pol2qm74	7363	4	suggest	suggest	VBP
cord-015021-pol2qm74	7363	5	that	that	IN
cord-015021-pol2qm74	7363	6	rhG	rhG	NNP
cord-015021-pol2qm74	7363	7	-	-	HYPH
cord-015021-pol2qm74	7363	8	CSF	CSF	NNP
cord-015021-pol2qm74	7363	9	is	be	VBZ
cord-015021-pol2qm74	7363	10	well	well	RB
cord-015021-pol2qm74	7363	11	tolerated	tolerate	VBN
cord-015021-pol2qm74	7363	12	at	at	IN
cord-015021-pol2qm74	7363	13	all	all	DT
cord-015021-pol2qm74	7363	14	gestational	gestational	JJ
cord-015021-pol2qm74	7363	15	ages	age	NNS
cord-015021-pol2qm74	7363	16	in	in	IN
cord-015021-pol2qm74	7363	17	newborns	newborn	NNS
cord-015021-pol2qm74	7363	18	with	with	IN
cord-015021-pol2qm74	7363	19	presumed	presume	VBN
cord-015021-pol2qm74	7363	20	sepsis	sepsis	NN
cord-015021-pol2qm74	7363	21	.	.	.
cord-015021-pol2qm74	7364	1	A	a	DT
cord-015021-pol2qm74	7364	2	multi	multi	JJ
cord-015021-pol2qm74	7364	3	-	-	JJ
cord-015021-pol2qm74	7364	4	center	center	JJ
cord-015021-pol2qm74	7364	5	phase	phase	NN
cord-015021-pol2qm74	7364	6	II	II	NNP
cord-015021-pol2qm74	7364	7	/	/	SYM
cord-015021-pol2qm74	7364	8	III	iii	CD
cord-015021-pol2qm74	7364	9	randomized	randomize	VBD
cord-015021-pol2qm74	7364	10	double	double	JJ
cord-015021-pol2qm74	7364	11	-	-	HYPH
cord-015021-pol2qm74	7364	12	blindad	blindad	NN
cord-015021-pol2qm74	7364	13	placebo	placebo	NN
cord-015021-pol2qm74	7364	14	controlled	control	VBN
cord-015021-pol2qm74	7364	15	trial	trial	NN
cord-015021-pol2qm74	7364	16	is	be	VBZ
cord-015021-pol2qm74	7364	17	required	require	VBN
cord-015021-pol2qm74	7364	18	to	to	TO
cord-015021-pol2qm74	7364	19	determine	determine	VB
cord-015021-pol2qm74	7364	20	the	the	DT
cord-015021-pol2qm74	7364	21	efficacy	efficacy	NN
cord-015021-pol2qm74	7364	22	of	of	IN
cord-015021-pol2qm74	7364	23	rhG	rhG	NNP
cord-015021-pol2qm74	7364	24	-	-	HYPH
cord-015021-pol2qm74	7364	25	CSF	csf	NN
cord-015021-pol2qm74	7364	26	in	in	IN
cord-015021-pol2qm74	7364	27	this	this	DT
cord-015021-pol2qm74	7364	28	clinical	clinical	JJ
cord-015021-pol2qm74	7364	29	setting	setting	NN
cord-015021-pol2qm74	7364	30	.	.	.
cord-015021-pol2qm74	7364	31	 	 	_SP
cord-015021-pol2qm74	7365	1	We	-PRON-	PRP
cord-015021-pol2qm74	7365	2	investigated	investigate	VBD
cord-015021-pol2qm74	7365	3	the	the	DT
cord-015021-pol2qm74	7365	4	effects	effect	NNS
cord-015021-pol2qm74	7365	5	of	of	IN
cord-015021-pol2qm74	7365	6	recombinant	recombinant	JJ
cord-015021-pol2qm74	7365	7	canine	canine	JJ
cord-015021-pol2qm74	7365	8	granulocyte	granulocyte	NN
cord-015021-pol2qm74	7365	9	-	-	HYPH
cord-015021-pol2qm74	7365	10	colony	colony	NN
cord-015021-pol2qm74	7365	11	stimulating	stimulate	VBG
cord-015021-pol2qm74	7365	12	factor	factor	NN
cord-015021-pol2qm74	7365	13	(	(	-LRB-
cord-015021-pol2qm74	7365	14	G	G	NNP
cord-015021-pol2qm74	7365	15	-	-	HYPH
cord-015021-pol2qm74	7365	16	CSF	CSF	NNP
cord-015021-pol2qm74	7365	17	)	)	-RRB-
cord-015021-pol2qm74	7365	18	on	on	IN
cord-015021-pol2qm74	7365	19	survival	survival	NN
cord-015021-pol2qm74	7365	20	,	,	,
cord-015021-pol2qm74	7365	21	cardiopulmonary	cardiopulmonary	JJ
cord-015021-pol2qm74	7365	22	function	function	NN
cord-015021-pol2qm74	7365	23	,	,	,
cord-015021-pol2qm74	7365	24	serum	serum	NN
cord-015021-pol2qm74	7365	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7365	26	levels	level	NNS
cord-015021-pol2qm74	7365	27	and	and	CC
cord-015021-pol2qm74	7365	28	tumor	tumor	NN
cord-015021-pol2qm74	7365	29	necrosis	necrosis	NN
cord-015021-pol2qm74	7365	30	factor	factor	NN
cord-015021-pol2qm74	7365	31	(	(	-LRB-
cord-015021-pol2qm74	7365	32	TNF	TNF	NNP
cord-015021-pol2qm74	7365	33	)	)	-RRB-
cord-015021-pol2qm74	7365	34	levels	level	NNS
cord-015021-pol2qm74	7365	35	in	in	IN
cord-015021-pol2qm74	7365	36	a	a	DT
cord-015021-pol2qm74	7365	37	canine	canine	JJ
cord-015021-pol2qm74	7365	38	model	model	NN
cord-015021-pol2qm74	7365	39	of	of	IN
cord-015021-pol2qm74	7365	40	lethal	lethal	JJ
cord-015021-pol2qm74	7365	41	bacterial	bacterial	JJ
cord-015021-pol2qm74	7365	42	septic	septic	JJ
cord-015021-pol2qm74	7365	43	shock	shock	NN
cord-015021-pol2qm74	7365	44	(	(	-LRB-
cord-015021-pol2qm74	7365	45	Clinical	Clinical	NNP
cord-015021-pol2qm74	7365	46	Research.41:240	Research.41:240	NNPS
cord-015021-pol2qm74	7365	47	,	,	,
cord-015021-pol2qm74	7365	48	1993	1993	CD
cord-015021-pol2qm74	7365	49	)	)	-RRB-
cord-015021-pol2qm74	7365	50	.	.	.
cord-015021-pol2qm74	7366	1	Methods	method	NNS
cord-015021-pol2qm74	7366	2	:	:	:
cord-015021-pol2qm74	7366	3	Awake	awake	JJ
cord-015021-pol2qm74	7366	4	2	2	CD
cord-015021-pol2qm74	7366	5	ylo	ylo	NNP
cord-015021-pol2qm74	7366	6	beagles	beagle	NNS
cord-015021-pol2qm74	7366	7	had	have	VBD
cord-015021-pol2qm74	7366	8	serial	serial	JJ
cord-015021-pol2qm74	7366	9	cardiopulmonary	cardiopulmonary	JJ
cord-015021-pol2qm74	7366	10	and	and	CC
cord-015021-pol2qm74	7366	11	laboratory	laboratory	NN
cord-015021-pol2qm74	7366	12	studies	study	NNS
cord-015021-pol2qm74	7366	13	before	before	IN
cord-015021-pol2qm74	7366	14	and	and	CC
cord-015021-pol2qm74	7366	15	for	for	IN
cord-015021-pol2qm74	7366	16	up	up	IN
cord-015021-pol2qm74	7366	17	to	to	TO
cord-015021-pol2qm74	7366	18	10	10	CD
cord-015021-pol2qm74	7366	19	days	day	NNS
cord-015021-pol2qm74	7366	20	after	after	IN
cord-015021-pol2qm74	7366	21	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	7366	22	placement	placement	NN
cord-015021-pol2qm74	7366	23	of	of	IN
cord-015021-pol2qm74	7366	24	an	an	DT
cord-015021-pol2qm74	7366	25	E.	E.	NNP
cord-015021-pol2qm74	7366	26	celi	celi	NNS
cord-015021-pol2qm74	7366	27	infected	infected	JJ
cord-015021-pol2qm74	7366	28	clot	clot	NN
cord-015021-pol2qm74	7366	29	.	.	.
cord-015021-pol2qm74	7367	1	Nine	nine	CD
cord-015021-pol2qm74	7367	2	days	day	NNS
cord-015021-pol2qm74	7367	3	before	before	IN
cord-015021-pol2qm74	7367	4	and	and	CC
cord-015021-pol2qm74	7367	5	daily	daily	RB
cord-015021-pol2qm74	7367	6	until	until	IN
cord-015021-pol2qm74	7367	7	3	3	CD
cord-015021-pol2qm74	7367	8	days	day	NNS
cord-015021-pol2qm74	7367	9	after	after	IN
cord-015021-pol2qm74	7367	10	clot	clot	NN
cord-015021-pol2qm74	7367	11	placement	placement	NN
cord-015021-pol2qm74	7367	12	,	,	,
cord-015021-pol2qm74	7367	13	animals	animal	NNS
cord-015021-pol2qm74	7367	14	received	receive	VBD
cord-015021-pol2qm74	7367	15	high	high	JJ
cord-015021-pol2qm74	7367	16	(	(	-LRB-
cord-015021-pol2qm74	7367	17	n=17	n=17	NNP
cord-015021-pol2qm74	7367	18	)	)	-RRB-
cord-015021-pol2qm74	7367	19	or	or	CC
cord-015021-pol2qm74	7367	20	low	low	JJ
cord-015021-pol2qm74	7367	21	dose	dose	NN
cord-015021-pol2qm74	7367	22	(	(	-LRB-
cord-015021-pol2qm74	7367	23	n=17	n=17	NN
cord-015021-pol2qm74	7367	24	)	)	-RRB-
cord-015021-pol2qm74	7367	25	G	G	NNP
cord-015021-pol2qm74	7367	26	-	-	HYPH
cord-015021-pol2qm74	7367	27	CSF	csf	NN
cord-015021-pol2qm74	7367	28	or	or	CC
cord-015021-pol2qm74	7367	29	protein	protein	NN
cord-015021-pol2qm74	7367	30	control	control	NN
cord-015021-pol2qm74	7367	31	(	(	-LRB-
cord-015021-pol2qm74	7367	32	n=20	n=20	NNP
cord-015021-pol2qm74	7367	33	)	)	-RRB-
cord-015021-pol2qm74	7367	34	subcutaneously	subcutaneously	RB
cord-015021-pol2qm74	7367	35	.	.	.
cord-015021-pol2qm74	7368	1	Results	result	NNS
cord-015021-pol2qm74	7368	2	:	:	:
cord-015021-pol2qm74	7369	1	Survival	survival	NN
cord-015021-pol2qm74	7369	2	in	in	IN
cord-015021-pol2qm74	7369	3	high	high	JJ
cord-015021-pol2qm74	7369	4	dose	dose	NN
cord-015021-pol2qm74	7369	5	G	G	NNP
cord-015021-pol2qm74	7369	6	-	-	HYPH
cord-015021-pol2qm74	7369	7	CSF	csf	NN
cord-015021-pol2qm74	7369	8	animals	animal	NNS
cord-015021-pol2qm74	7369	9	(	(	-LRB-
cord-015021-pol2qm74	7369	10	14/17	14/17	CD
cord-015021-pol2qm74	7369	11	)	)	-RRB-
cord-015021-pol2qm74	7369	12	was	be	VBD
cord-015021-pol2qm74	7369	13	significantly	significantly	RB
cord-015021-pol2qm74	7369	14	improved	improve	VBN
cord-015021-pol2qm74	7369	15	compared	compare	VBN
cord-015021-pol2qm74	7369	16	to	to	IN
cord-015021-pol2qm74	7369	17	low	low	JJ
cord-015021-pol2qm74	7369	18	dose	dose	NN
cord-015021-pol2qm74	7369	19	(	(	-LRB-
cord-015021-pol2qm74	7369	20	10117	10117	CD
cord-015021-pol2qm74	7369	21	)	)	-RRB-
cord-015021-pol2qm74	7369	22	and	and	CC
cord-015021-pol2qm74	7369	23	controls	control	NNS
cord-015021-pol2qm74	7369	24	(	(	-LRB-
cord-015021-pol2qm74	7369	25	12120	12120	CD
cord-015021-pol2qm74	7369	26	)	)	-RRB-
cord-015021-pol2qm74	7369	27	(	(	-LRB-
cord-015021-pol2qm74	7369	28	p<0.04	p<0.04	CD
cord-015021-pol2qm74	7369	29	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	7369	30	)	)	-RRB-
cord-015021-pol2qm74	7369	31	.	.	.
cord-015021-pol2qm74	7370	1	High	high	JJ
cord-015021-pol2qm74	7370	2	dose	dose	NN
cord-015021-pol2qm74	7370	3	G	G	NNP
cord-015021-pol2qm74	7370	4	-	-	HYPH
cord-015021-pol2qm74	7370	5	CSF	CSF	NNP
cord-015021-pol2qm74	7370	6	also	also	RB
cord-015021-pol2qm74	7370	7	improved	improve	VBD
cord-015021-pol2qm74	7370	8	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	7370	9	function	function	NN
cord-015021-pol2qm74	7370	10	evidenced	evidence	VBN
cord-015021-pol2qm74	7370	11	by	by	IN
cord-015021-pol2qm74	7370	12	a	a	DT
cord-015021-pol2qm74	7370	13	higher	high	JJR
cord-015021-pol2qm74	7370	14	mean	mean	NN
cord-015021-pol2qm74	7370	15	left	leave	VBN
cord-015021-pol2qm74	7370	16	ventricular	ventricular	JJ
cord-015021-pol2qm74	7370	17	ejection	ejection	NN
cord-015021-pol2qm74	7370	18	fraction	fraction	NN
cord-015021-pol2qm74	7370	19	(	(	-LRB-
cord-015021-pol2qm74	7370	20	day	day	NN
cord-015021-pol2qm74	7370	21	1	1	CD
cord-015021-pol2qm74	7370	22	after	after	IN
cord-015021-pol2qm74	7370	23	clot	clot	NN
cord-015021-pol2qm74	7370	24	,	,	,
cord-015021-pol2qm74	7370	25	p<0.001	p<0.001	CD
cord-015021-pol2qm74	7370	26	)	)	-RRB-
cord-015021-pol2qm74	7370	27	and	and	CC
cord-015021-pol2qm74	7370	28	mean	mean	VB
cord-015021-pol2qm74	7370	29	arterial	arterial	JJ
cord-015021-pol2qm74	7370	30	pressure	pressure	NN
cord-015021-pol2qm74	7370	31	(	(	-LRB-
cord-015021-pol2qm74	7370	32	day	day	NN
cord-015021-pol2qm74	7370	33	2	2	CD
cord-015021-pol2qm74	7370	34	,	,	,
cord-015021-pol2qm74	7370	35	p<0,02	p<0,02	NNP
cord-015021-pol2qm74	7370	36	)	)	-RRB-
cord-015021-pol2qm74	7370	37	compared	compare	VBN
cord-015021-pol2qm74	7370	38	to	to	IN
cord-015021-pol2qm74	7370	39	low	low	JJ
cord-015021-pol2qm74	7370	40	dose	dose	NN
cord-015021-pol2qm74	7370	41	and	and	CC
cord-015021-pol2qm74	7370	42	controls	control	NNS
cord-015021-pol2qm74	7370	43	.	.	.
cord-015021-pol2qm74	7371	1	High	high	JJ
cord-015021-pol2qm74	7371	2	dose	dose	NN
cord-015021-pol2qm74	7371	3	rcG	rcG	NNP
cord-015021-pol2qm74	7371	4	-	-	HYPH
cord-015021-pol2qm74	7371	5	CSF	csf	NN
cord-015021-pol2qm74	7371	6	increased	increase	VBD
cord-015021-pol2qm74	7371	7	(	(	-LRB-
cord-015021-pol2qm74	7371	8	p<0.001	p<0.001	JJ
cord-015021-pol2qm74	7371	9	)	)	-RRB-
cord-015021-pol2qm74	7371	10	peripheral	peripheral	JJ
cord-015021-pol2qm74	7371	11	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7371	12	numbers	number	NNS
cord-015021-pol2qm74	7371	13	both	both	CC
cord-015021-pol2qm74	7371	14	before	before	IN
cord-015021-pol2qm74	7371	15	and	and	CC
cord-015021-pol2qm74	7371	16	after	after	IN
cord-015021-pol2qm74	7371	17	clot	clot	NN
cord-015021-pol2qm74	7371	18	implantation	implantation	NN
cord-015021-pol2qm74	7371	19	(	(	-LRB-
cord-015021-pol2qm74	7371	20	2	2	CD
cord-015021-pol2qm74	7371	21	hours	hour	NNS
cord-015021-pol2qm74	7371	22	to	to	IN
cord-015021-pol2qm74	7371	23	4	4	CD
cord-015021-pol2qm74	7371	24	days	day	NNS
cord-015021-pol2qm74	7371	25	)	)	-RRB-
cord-015021-pol2qm74	7371	26	compared	compare	VBN
cord-015021-pol2qm74	7371	27	to	to	IN
cord-015021-pol2qm74	7371	28	low	low	JJ
cord-015021-pol2qm74	7371	29	dose	dose	NN
cord-015021-pol2qm74	7371	30	and	and	CC
cord-015021-pol2qm74	7371	31	controls	control	NNS
cord-015021-pol2qm74	7371	32	.	.	.
cord-015021-pol2qm74	7372	1	In	in	IN
cord-015021-pol2qm74	7372	2	addition	addition	NN
cord-015021-pol2qm74	7372	3	,	,	,
cord-015021-pol2qm74	7372	4	high	high	JJ
cord-015021-pol2qm74	7372	5	dose	dose	NN
cord-015021-pol2qm74	7372	6	rcG	rcG	NNP
cord-015021-pol2qm74	7372	7	-	-	HYPH
cord-015021-pol2qm74	7372	8	CSF	CSF	NNP
cord-015021-pol2qm74	7372	9	produced	produce	VBD
cord-015021-pol2qm74	7372	10	a	a	DT
cord-015021-pol2qm74	7372	11	more	more	RBR
cord-015021-pol2qm74	7372	12	rapid	rapid	JJ
cord-015021-pol2qm74	7372	13	(	(	-LRB-
cord-015021-pol2qm74	7372	14	p<0.0001	p<0.0001	NNP
cord-015021-pol2qm74	7372	15	)	)	-RRB-
cord-015021-pol2qm74	7372	16	rise	rise	NN
cord-015021-pol2qm74	7372	17	(	(	-LRB-
cord-015021-pol2qm74	7372	18	day	day	NN
cord-015021-pol2qm74	7372	19	2	2	CD
cord-015021-pol2qm74	7372	20	)	)	-RRB-
cord-015021-pol2qm74	7372	21	and	and	CC
cord-015021-pol2qm74	7372	22	fall	fall	VB
cord-015021-pol2qm74	7372	23	(	(	-LRB-
cord-015021-pol2qm74	7372	24	day	day	NN
cord-015021-pol2qm74	7372	25	4	4	CD
cord-015021-pol2qm74	7372	26	)	)	-RRB-
cord-015021-pol2qm74	7372	27	in	in	IN
cord-015021-pol2qm74	7372	28	alveolar	alveolar	JJ
cord-015021-pol2qm74	7372	29	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7372	30	determined	determine	VBN
cord-015021-pol2qm74	7372	31	by	by	IN
cord-015021-pol2qm74	7372	32	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	7372	33	lavage	lavage	NN
cord-015021-pol2qm74	7372	34	compared	compare	VBN
cord-015021-pol2qm74	7372	35	to	to	IN
cord-015021-pol2qm74	7372	36	low	low	JJ
cord-015021-pol2qm74	7372	37	dose	dose	NN
cord-015021-pol2qm74	7372	38	and	and	CC
cord-015021-pol2qm74	7372	39	controls	control	NNS
cord-015021-pol2qm74	7372	40	.	.	.
cord-015021-pol2qm74	7373	1	Lastly	lastly	RB
cord-015021-pol2qm74	7373	2	,	,	,
cord-015021-pol2qm74	7373	3	high	high	JJ
cord-015021-pol2qm74	7373	4	dose	dose	NN
cord-015021-pol2qm74	7373	5	rcG	rcG	NNP
cord-015021-pol2qm74	7373	6	-	-	HYPH
cord-015021-pol2qm74	7373	7	CSF	csf	NN
cord-015021-pol2qm74	7373	8	decreased	decrease	VBD
cord-015021-pol2qm74	7373	9	serum	serum	NN
cord-015021-pol2qm74	7373	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7373	11	(	(	-LRB-
cord-015021-pol2qm74	7373	12	2	2	CD
cord-015021-pol2qm74	7373	13	to	to	IN
cord-015021-pol2qm74	7373	14	8h	8h	NNP
cord-015021-pol2qm74	7373	15	,	,	,
cord-015021-pol2qm74	7373	16	p<0.002	p<0.002	CD
cord-015021-pol2qm74	7373	17	)	)	-RRB-
cord-015021-pol2qm74	7373	18	and	and	CC
cord-015021-pol2qm74	7373	19	tumor	tumor	NN
cord-015021-pol2qm74	7373	20	necrosis	necrosis	NN
cord-015021-pol2qm74	7373	21	factor	factor	NN
cord-015021-pol2qm74	7373	22	(	(	-LRB-
cord-015021-pol2qm74	7373	23	TNF	TNF	NNP
cord-015021-pol2qm74	7373	24	,	,	,
cord-015021-pol2qm74	7373	25	2h	2h	CD
cord-015021-pol2qm74	7373	26	,	,	,
cord-015021-pol2qm74	7373	27	p<0.02	p<0.02	NN
cord-015021-pol2qm74	7373	28	)	)	-RRB-
cord-015021-pol2qm74	7373	29	levels	level	NNS
cord-015021-pol2qm74	7373	30	compared	compare	VBN
cord-015021-pol2qm74	7373	31	to	to	IN
cord-015021-pol2qm74	7373	32	low	low	JJ
cord-015021-pol2qm74	7373	33	dose	dose	NN
cord-015021-pol2qm74	7373	34	and	and	CC
cord-015021-pol2qm74	7373	35	controls	control	NNS
cord-015021-pol2qm74	7373	36	.	.	.
cord-015021-pol2qm74	7374	1	Discussion	discussion	NN
cord-015021-pol2qm74	7374	2	:	:	:
cord-015021-pol2qm74	7375	1	These	these	DT
cord-015021-pol2qm74	7375	2	data	datum	NNS
cord-015021-pol2qm74	7375	3	suggest	suggest	VBP
cord-015021-pol2qm74	7375	4	that	that	IN
cord-015021-pol2qm74	7375	5	therapy	therapy	NN
cord-015021-pol2qm74	7375	6	with	with	IN
cord-015021-pol2qm74	7375	7	G	G	NNP
cord-015021-pol2qm74	7375	8	-	-	HYPH
cord-015021-pol2qm74	7375	9	CSF	CSF	NNP
cord-015021-pol2qm74	7375	10	sufficient	sufficient	JJ
cord-015021-pol2qm74	7375	11	to	to	TO
cord-015021-pol2qm74	7375	12	increase	increase	VB
cord-015021-pol2qm74	7375	13	peripheral	peripheral	JJ
cord-015021-pol2qm74	7375	14	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7375	15	numbers	number	NNS
cord-015021-pol2qm74	7375	16	during	during	IN
cord-015021-pol2qm74	7375	17	peritonitis	peritonitis	NN
cord-015021-pol2qm74	7375	18	and	and	CC
cord-015021-pol2qm74	7375	19	septic	septic	JJ
cord-015021-pol2qm74	7375	20	shock	shock	NN
cord-015021-pol2qm74	7375	21	may	may	MD
cord-015021-pol2qm74	7375	22	augment	augment	VB
cord-015021-pol2qm74	7375	23	host	host	NN
cord-015021-pol2qm74	7375	24	defense	defense	NN
cord-015021-pol2qm74	7375	25	and	and	CC
cord-015021-pol2qm74	7375	26	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7375	27	clearance	clearance	NN
cord-015021-pol2qm74	7375	28	,	,	,
cord-015021-pol2qm74	7375	29	reduce	reduce	VB
cord-015021-pol2qm74	7375	30	cytokine	cytokine	NN
cord-015021-pol2qm74	7375	31	levels	level	NNS
cord-015021-pol2qm74	7375	32	(	(	-LRB-
cord-015021-pol2qm74	7375	33	TNF	TNF	NNP
cord-015021-pol2qm74	7375	34	)	)	-RRB-
cord-015021-pol2qm74	7375	35	and	and	CC
cord-015021-pol2qm74	7375	36	improve	improve	VB
cord-015021-pol2qm74	7375	37	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	7375	38	function	function	NN
cord-015021-pol2qm74	7375	39	and	and	CC
cord-015021-pol2qm74	7375	40	survival	survival	NN
cord-015021-pol2qm74	7375	41	.	.	.
cord-015021-pol2qm74	7376	1	The	the	DT
cord-015021-pol2qm74	7376	2	use	use	NN
cord-015021-pol2qm74	7376	3	of	of	IN
cord-015021-pol2qm74	7376	4	G	G	NNP
cord-015021-pol2qm74	7376	5	-	-	HYPH
cord-015021-pol2qm74	7376	6	CSF	CSF	NNP
cord-015021-pol2qm74	7376	7	in	in	IN
cord-015021-pol2qm74	7376	8	sepsis	sepsis	NN
cord-015021-pol2qm74	7376	9	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	7376	10	in	in	IN
cord-015021-pol2qm74	7376	11	neutropenic	neutropenic	JJ
cord-015021-pol2qm74	7376	12	patients	patient	NNS
cord-015021-pol2qm74	7376	13	is	be	VBZ
cord-015021-pol2qm74	7376	14	well	well	RB
cord-015021-pol2qm74	7376	15	established	establish	VBN
cord-015021-pol2qm74	7376	16	and	and	CC
cord-015021-pol2qm74	7376	17	has	have	VBZ
cord-015021-pol2qm74	7376	18	been	be	VBN
cord-015021-pol2qm74	7376	19	ascribed	ascribe	VBN
cord-015021-pol2qm74	7376	20	to	to	IN
cord-015021-pol2qm74	7376	21	accelerated	accelerate	VBN
cord-015021-pol2qm74	7376	22	recovery	recovery	NN
cord-015021-pol2qm74	7376	23	in	in	IN
cord-015021-pol2qm74	7376	24	granulccyte	granulccyte	NNP
cord-015021-pol2qm74	7376	25	counts	count	VBZ
cord-015021-pol2qm74	7376	26	.	.	.
cord-015021-pol2qm74	7377	1	Here	here	RB
cord-015021-pol2qm74	7377	2	,	,	,
cord-015021-pol2qm74	7377	3	an	an	DT
cord-015021-pol2qm74	7377	4	additional	additional	JJ
cord-015021-pol2qm74	7377	5	sepsis	sepsis	NN
cord-015021-pol2qm74	7377	6	-	-	HYPH
cord-015021-pol2qm74	7377	7	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	7377	8	property	property	NN
cord-015021-pol2qm74	7377	9	could	could	MD
cord-015021-pol2qm74	7377	10	be	be	VB
cord-015021-pol2qm74	7377	11	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7377	12	in	in	IN
cord-015021-pol2qm74	7377	13	healthy	healthy	JJ
cord-015021-pol2qm74	7377	14	volunteers	volunteer	NNS
cord-015021-pol2qm74	7377	15	:	:	:
cord-015021-pol2qm74	7377	16	Eleven	eleven	CD
cord-015021-pol2qm74	7377	17	volunteers	volunteer	NNS
cord-015021-pol2qm74	7377	18	were	be	VBD
cord-015021-pol2qm74	7377	19	employed	employ	VBN
cord-015021-pol2qm74	7377	20	in	in	IN
cord-015021-pol2qm74	7377	21	a	a	DT
cord-015021-pol2qm74	7377	22	sinqle	sinqle	NNP
cord-015021-pol2qm74	7377	23	-	-	HYPH
cord-015021-pol2qm74	7377	24	bTind	bTind	NNP
cord-015021-pol2qm74	7377	25	,	,	,
cord-015021-pol2qm74	7377	26	controlled	controlled	JJ
cord-015021-pol2qm74	7377	27	study	study	NN
cord-015021-pol2qm74	7377	28	and	and	CC
cord-015021-pol2qm74	7377	29	were	be	VBD
cord-015021-pol2qm74	7377	30	given	give	VBN
cord-015021-pol2qm74	7377	31	480	480	CD
cord-015021-pol2qm74	7377	32	uq	uq	NNP
cord-015021-pol2qm74	7377	33	G	G	NNP
cord-015021-pol2qm74	7377	34	-	-	HYPH
cord-015021-pol2qm74	7377	35	CSF	CSF	NNP
cord-015021-pol2qm74	7377	36	or	or	CC
cord-015021-pol2qm74	7377	37	saline	saline	NN
cord-015021-pol2qm74	7377	38	placebo	placebo	NN
cord-015021-pol2qm74	7377	39	via	via	IN
cord-015021-pol2qm74	7377	40	subcutaneous	subcutaneous	JJ
cord-015021-pol2qm74	7377	41	injection	injection	NN
cord-015021-pol2qm74	7377	42	.	.	.
cord-015021-pol2qm74	7378	1	Blood	blood	NN
cord-015021-pol2qm74	7378	2	was	be	VBD
cord-015021-pol2qm74	7378	3	withdrawn	withdraw	VBN
cord-015021-pol2qm74	7378	4	immediately	immediately	RB
cord-015021-pol2qm74	7378	5	before	before	RB
cord-015021-pol2qm74	7378	6	and	and	CC
cord-015021-pol2qm74	7378	7	20	20	CD
cord-015021-pol2qm74	7378	8	or	or	CC
cord-015021-pol2qm74	7378	9	44	44	CD
cord-015021-pol2qm74	7378	10	hours	hour	NNS
cord-015021-pol2qm74	7378	11	later	later	RB
cord-015021-pol2qm74	7378	12	.	.	.
cord-015021-pol2qm74	7379	1	LPS	LPS	NNP
cord-015021-pol2qm74	7379	2	-	-	HYPH
cord-015021-pol2qm74	7379	3	inducible	inducible	JJ
cord-015021-pol2qm74	7379	4	TNF	TNF	NNP
cord-015021-pol2qm74	7379	5	,	,	,
cord-015021-pol2qm74	7379	6	IL-1	IL-1	NNP
cord-015021-pol2qm74	7379	7	,	,	,
cord-015021-pol2qm74	7379	8	sTNF	stnf	NN
cord-015021-pol2qm74	7379	9	-	-	HYPH
cord-015021-pol2qm74	7379	10	R	r	JJ
cord-015021-pol2qm74	7379	11	p75	p75	NN
cord-015021-pol2qm74	7379	12	and	and	CC
cord-015021-pol2qm74	7379	13	IL	IL	NNP
cord-015021-pol2qm74	7379	14	-	-	HYPH
cord-015021-pol2qm74	7379	15	lra	lra	NNP
cord-015021-pol2qm74	7379	16	were	be	VBD
cord-015021-pol2qm74	7379	17	assessed	assess	VBN
cord-015021-pol2qm74	7379	18	in	in	IN
cord-015021-pol2qm74	7379	19	the	the	DT
cord-015021-pol2qm74	7379	20	supernatant	supernatant	NN
cord-015021-pol2qm74	7379	21	of	of	IN
cord-015021-pol2qm74	7379	22	whole	whole	JJ
cord-015021-pol2qm74	7379	23	blood	blood	NN
cord-015021-pol2qm74	7379	24	incubations	incubation	NNS
cord-015021-pol2qm74	7379	25	stimulated	stimulate	VBN
cord-015021-pol2qm74	7379	26	with	with	IN
cord-015021-pol2qm74	7379	27	10	10	CD
cord-015021-pol2qm74	7379	28	ug	ug	NNP
cord-015021-pol2qm74	7379	29	/	/	SYM
cord-015021-pol2qm74	7379	30	ml	ml	NN
cord-015021-pol2qm74	7379	31	LPS	LPS	NNP
cord-015021-pol2qm74	7379	32	from	from	IN
cord-015021-pol2qm74	7379	33	Salmonella	Salmonella	NNP
cord-015021-pol2qm74	7379	34	abortus	abortus	NN
cord-015021-pol2qm74	7379	35	equi	equi	NN
cord-015021-pol2qm74	7379	36	.	.	.
cord-015021-pol2qm74	7380	1	Similarly	similarly	RB
cord-015021-pol2qm74	7380	2	to	to	IN
cord-015021-pol2qm74	7380	3	previous	previous	JJ
cord-015021-pol2qm74	7380	4	animal	animal	NN
cord-015021-pol2qm74	7380	5	studies	study	NNS
cord-015021-pol2qm74	7380	6	,	,	,
cord-015021-pol2qm74	7380	7	LPS	LPS	NNP
cord-015021-pol2qm74	7380	8	-	-	HYPH
cord-015021-pol2qm74	7380	9	inducible	inducible	JJ
cord-015021-pol2qm74	7380	10	TNF	TNF	NNP
cord-015021-pol2qm74	7380	11	was	be	VBD
cord-015021-pol2qm74	7380	12	attenuated	attenuate	VBN
cord-015021-pol2qm74	7380	13	by	by	IN
cord-015021-pol2qm74	7380	14	about	about	RB
cord-015021-pol2qm74	7380	15	50	50	CD
cord-015021-pol2qm74	7380	16	%	%	NN
cord-015021-pol2qm74	7380	17	20	20	CD
cord-015021-pol2qm74	7380	18	hrs	hrs	NN
cord-015021-pol2qm74	7380	19	.	.	.
cord-015021-pol2qm74	7381	1	after	after	IN
cord-015021-pol2qm74	7381	2	treatment	treatment	NN
cord-015021-pol2qm74	7381	3	.	.	.
cord-015021-pol2qm74	7382	1	The	the	DT
cord-015021-pol2qm74	7382	2	same	same	JJ
cord-015021-pol2qm74	7382	3	was	be	VBD
cord-015021-pol2qm74	7382	4	true	true	JJ
cord-015021-pol2qm74	7382	5	of	of	IN
cord-015021-pol2qm74	7382	6	IL	IL	NNP
cord-015021-pol2qm74	7382	7	-	-	HYPH
cord-015021-pol2qm74	7382	8	lb	lb	NN
cord-015021-pol2qm74	7382	9	.	.	.
cord-015021-pol2qm74	7383	1	In	in	IN
cord-015021-pol2qm74	7383	2	contrast	contrast	NN
cord-015021-pol2qm74	7383	3	,	,	,
cord-015021-pol2qm74	7383	4	LPS	LPS	NNP
cord-015021-pol2qm74	7383	5	-	-	HYPH
cord-015021-pol2qm74	7383	6	inducible	inducible	JJ
cord-015021-pol2qm74	7383	7	sTNF	stnf	NN
cord-015021-pol2qm74	7383	8	-	-	HYPH
cord-015021-pol2qm74	7383	9	R	r	NN
cord-015021-pol2qm74	7383	10	p75	p75	NN
cord-015021-pol2qm74	7383	11	which	which	WDT
cord-015021-pol2qm74	7383	12	was	be	VBD
cord-015021-pol2qm74	7383	13	indetectable	indetectable	JJ
cord-015021-pol2qm74	7383	14	in	in	IN
cord-015021-pol2qm74	7383	15	blood	blood	NN
cord-015021-pol2qm74	7383	16	incubations	incubation	NNS
cord-015021-pol2qm74	7383	17	from	from	IN
cord-015021-pol2qm74	7383	18	untreated	untreated	JJ
cord-015021-pol2qm74	7383	19	donors	donor	NNS
cord-015021-pol2qm74	7383	20	increased	increase	VBD
cord-015021-pol2qm74	7383	21	dramatically	dramatically	RB
cord-015021-pol2qm74	7383	22	44	44	CD
cord-015021-pol2qm74	7383	23	hrs	hrs	NN
cord-015021-pol2qm74	7383	24	.	.	.
cord-015021-pol2qm74	7384	1	after	after	IN
cord-015021-pol2qm74	7384	2	G	G	NNP
cord-015021-pol2qm74	7384	3	-	-	HYPH
cord-015021-pol2qm74	7384	4	CSF	csf	NN
cord-015021-pol2qm74	7384	5	treatment	treatment	NN
cord-015021-pol2qm74	7384	6	.	.	.
cord-015021-pol2qm74	7385	1	IL	IL	NNP
cord-015021-pol2qm74	7385	2	-	-	HYPH
cord-015021-pol2qm74	7385	3	lra	lra	NNP
cord-015021-pol2qm74	7385	4	found	find	VBD
cord-015021-pol2qm74	7385	5	after	after	IN
cord-015021-pol2qm74	7385	6	LPS	LPS	NNP
cord-015021-pol2qm74	7385	7	challenge	challenge	NN
cord-015021-pol2qm74	7385	8	was	be	VBD
cord-015021-pol2qm74	7385	9	increased	increase	VBN
cord-015021-pol2qm74	7385	10	tenfold	tenfold	RB
cord-015021-pol2qm74	7385	11	by	by	IN
cord-015021-pol2qm74	7385	12	G	G	NNP
cord-015021-pol2qm74	7385	13	-	-	HYPH
cord-015021-pol2qm74	7385	14	CSF	CSF	NNP
cord-015021-pol2qm74	7385	15	treatment	treatment	NN
cord-015021-pol2qm74	7385	16	.	.	.
cord-015021-pol2qm74	7386	1	It	-PRON-	PRP
cord-015021-pol2qm74	7386	2	is	be	VBZ
cord-015021-pol2qm74	7386	3	concluded	conclude	VBN
cord-015021-pol2qm74	7386	4	that	that	IN
cord-015021-pol2qm74	7386	5	G	G	NNP
cord-015021-pol2qm74	7386	6	-	-	HYPH
cord-015021-pol2qm74	7386	7	CSF	CSF	NNP
cord-015021-pol2qm74	7386	8	treatment	treatment	NN
cord-015021-pol2qm74	7386	9	switches	switch	VBZ
cord-015021-pol2qm74	7386	10	peripheral	peripheral	JJ
cord-015021-pol2qm74	7386	11	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7386	12	to	to	IN
cord-015021-pol2qm74	7386	13	an	an	DT
cord-015021-pol2qm74	7386	14	antiinflammatery	antiinflammatery	JJ
cord-015021-pol2qm74	7386	15	state	state	NN
cord-015021-pol2qm74	7386	16	characterized	characterize	VBN
cord-015021-pol2qm74	7386	17	by	by	IN
cord-015021-pol2qm74	7386	18	an	an	DT
cord-015021-pol2qm74	7386	19	attenuation	attenuation	NN
cord-015021-pol2qm74	7386	20	of	of	IN
cord-015021-pol2qm74	7386	21	IL	IL	NNP
cord-015021-pol2qm74	7386	22	-	-	:
cord-015021-pol2qm74	7386	23	I	I	NNP
cord-015021-pol2qm74	7386	24	and	and	CC
cord-015021-pol2qm74	7386	25	TNF	TNF	NNP
cord-015021-pol2qm74	7386	26	releasing	release	VBG
cord-015021-pol2qm74	7386	27	capacity	capacity	NN
cord-015021-pol2qm74	7386	28	and	and	CC
cord-015021-pol2qm74	7386	29	an	an	DT
cord-015021-pol2qm74	7386	30	augmentation	augmentation	NN
cord-015021-pol2qm74	7386	31	of	of	IN
cord-015021-pol2qm74	7386	32	the	the	DT
cord-015021-pol2qm74	7386	33	release	release	NN
cord-015021-pol2qm74	7386	34	of	of	IN
cord-015021-pol2qm74	7386	35	cytokine	cytokine	JJ
cord-015021-pol2qm74	7386	36	antagonists	antagonist	NNS
cord-015021-pol2qm74	7386	37	.	.	.
cord-015021-pol2qm74	7387	1	This	this	DT
cord-015021-pol2qm74	7387	2	findinq	findinq	NNP
cord-015021-pol2qm74	7387	3	minht	minht	NNP
cord-015021-pol2qm74	7387	4	offer	offer	VBP
cord-015021-pol2qm74	7387	5	a	a	DT
cord-015021-pol2qm74	7387	6	novel	novel	JJ
cord-015021-pol2qm74	7387	7	concept	concept	NN
cord-015021-pol2qm74	7387	8	in	in	IN
cord-015021-pol2qm74	7387	9	septic	septic	JJ
cord-015021-pol2qm74	7387	10	shock	shock	NN
cord-015021-pol2qm74	7387	11	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	7387	12	.	.	.
cord-015021-pol2qm74	7388	1	Objective	objective	JJ
cord-015021-pol2qm74	7388	2	.	.	.
cord-015021-pol2qm74	7389	1	The	the	DT
cord-015021-pol2qm74	7389	2	aim	aim	NN
cord-015021-pol2qm74	7389	3	of	of	IN
cord-015021-pol2qm74	7389	4	the	the	DT
cord-015021-pol2qm74	7389	5	study	study	NN
cord-015021-pol2qm74	7389	6	was	be	VBD
cord-015021-pol2qm74	7389	7	to	to	TO
cord-015021-pol2qm74	7389	8	investigate	investigate	VB
cord-015021-pol2qm74	7389	9	the	the	DT
cord-015021-pol2qm74	7389	10	effect	effect	NN
cord-015021-pol2qm74	7389	11	of	of	IN
cord-015021-pol2qm74	7389	12	recombinant	recombinant	JJ
cord-015021-pol2qm74	7389	13	human	human	JJ
cord-015021-pol2qm74	7389	14	G	G	NNP
cord-015021-pol2qm74	7389	15	-	-	HYPH
cord-015021-pol2qm74	7389	16	CSF	CSF	NNP
cord-015021-pol2qm74	7389	17	(	(	-LRB-
cord-015021-pol2qm74	7389	18	rhG	rhG	NNP
cord-015021-pol2qm74	7389	19	-	-	HYPH
cord-015021-pol2qm74	7389	20	CSF	CSF	NNP
cord-015021-pol2qm74	7389	21	)	)	-RRB-
cord-015021-pol2qm74	7389	22	on	on	IN
cord-015021-pol2qm74	7389	23	survival	survival	NN
cord-015021-pol2qm74	7389	24	,	,	,
cord-015021-pol2qm74	7389	25	bone	bone	NN
cord-015021-pol2qm74	7389	26	marrow	marrow	NN
cord-015021-pol2qm74	7389	27	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7389	28	myelopoiesis	myelopoiesis	NN
cord-015021-pol2qm74	7389	29	,	,	,
cord-015021-pol2qm74	7389	30	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7389	31	counts	count	NNS
cord-015021-pol2qm74	7389	32	,	,	,
cord-015021-pol2qm74	7389	33	levels	level	NNS
cord-015021-pol2qm74	7389	34	of	of	IN
cord-015021-pol2qm74	7389	35	bacteria	bacteria	NNS
cord-015021-pol2qm74	7389	36	and	and	CC
cord-015021-pol2qm74	7389	37	some	some	DT
cord-015021-pol2qm74	7389	38	important	important	JJ
cord-015021-pol2qm74	7389	39	sepsis	sepsis	NN
cord-015021-pol2qm74	7389	40	mediators	mediator	NNS
cord-015021-pol2qm74	7389	41	in	in	IN
cord-015021-pol2qm74	7389	42	a	a	DT
cord-015021-pol2qm74	7389	43	model	model	NN
cord-015021-pol2qm74	7389	44	of	of	IN
cord-015021-pol2qm74	7389	45	rat	rat	NN
cord-015021-pol2qm74	7389	46	abdominal	abdominal	JJ
cord-015021-pol2qm74	7389	47	sepsis	sepsis	NN
cord-015021-pol2qm74	7389	48	.	.	.
cord-015021-pol2qm74	7390	1	Lethal	lethal	JJ
cord-015021-pol2qm74	7390	2	peritonitis	peritonitis	NN
cord-015021-pol2qm74	7390	3	was	be	VBD
cord-015021-pol2qm74	7390	4	induced	induce	VBN
cord-015021-pol2qm74	7390	5	with	with	IN
cord-015021-pol2qm74	7390	6	a	a	DT
cord-015021-pol2qm74	7390	7	4	4	CD
cord-015021-pol2qm74	7390	8	mm	mm	NN
cord-015021-pol2qm74	7390	9	coecal	coecal	JJ
cord-015021-pol2qm74	7390	10	perforation	perforation	NN
cord-015021-pol2qm74	7390	11	(	(	-LRB-
cord-015021-pol2qm74	7390	12	CP	CP	NNP
cord-015021-pol2qm74	7390	13	)	)	-RRB-
cord-015021-pol2qm74	7390	14	in	in	IN
cord-015021-pol2qm74	7390	15	male	male	JJ
cord-015021-pol2qm74	7390	16	Wistar	Wistar	NNP
cord-015021-pol2qm74	7390	17	rats	rat	NNS
cord-015021-pol2qm74	7390	18	.	.	.
cord-015021-pol2qm74	7391	1	rhG	rhG	NNP
cord-015021-pol2qm74	7391	2	-	-	HYPH
cord-015021-pol2qm74	7391	3	CSF	CSF	NNP
cord-015021-pol2qm74	7391	4	was	be	VBD
cord-015021-pol2qm74	7391	5	administered	administer	VBN
cord-015021-pol2qm74	7391	6	as	as	IN
cord-015021-pol2qm74	7391	7	10	10	CD
cord-015021-pol2qm74	7391	8	/.tg	/.tg	.
cord-015021-pol2qm74	7392	1	/kg	/kg	.
cord-015021-pol2qm74	7393	1	iv	iv	LS
cord-015021-pol2qm74	7394	1	every	every	DT
cord-015021-pol2qm74	7394	2	12	12	CD
cord-015021-pol2qm74	7394	3	h	h	NN
cord-015021-pol2qm74	7394	4	,	,	,
cord-015021-pol2qm74	7394	5	first	first	JJ
cord-015021-pol2qm74	7394	6	dose	dose	NN
cord-015021-pol2qm74	7394	7	at	at	IN
cord-015021-pol2qm74	7394	8	sepsis	sepsis	NN
cord-015021-pol2qm74	7394	9	induction	induction	NN
cord-015021-pol2qm74	7394	10	.	.	.
cord-015021-pol2qm74	7395	1	Bone	bone	NN
cord-015021-pol2qm74	7395	2	marrow	marrow	NN
cord-015021-pol2qm74	7395	3	neutrophi	neutrophi	NNP
cord-015021-pol2qm74	7395	4	]	]	-RRB-
cord-015021-pol2qm74	7395	5	progenitors	progenitor	NNS
cord-015021-pol2qm74	7395	6	were	be	VBD
cord-015021-pol2qm74	7395	7	determined	determine	VBN
cord-015021-pol2qm74	7395	8	as	as	IN
cord-015021-pol2qm74	7395	9	blast	blast	NN
cord-015021-pol2qm74	7395	10	colonies	colony	NNS
cord-015021-pol2qm74	7395	11	,	,	,
cord-015021-pol2qm74	7395	12	CFU	CFU	NNP
cord-015021-pol2qm74	7395	13	-	-	HYPH
cord-015021-pol2qm74	7395	14	GM	GM	NNP
cord-015021-pol2qm74	7395	15	and	and	CC
cord-015021-pol2qm74	7395	16	CFU	CFU	NNP
cord-015021-pol2qm74	7395	17	-	-	HYPH
cord-015021-pol2qm74	7395	18	G.	G.	NNP
cord-015021-pol2qm74	7395	19	Neutrophils	Neutrophils	NNPS
cord-015021-pol2qm74	7395	20	and	and	CC
cord-015021-pol2qm74	7395	21	bacteria	bacteria	NNS
cord-015021-pol2qm74	7395	22	were	be	VBD
cord-015021-pol2qm74	7395	23	determined	determine	VBN
cord-015021-pol2qm74	7395	24	in	in	IN
cord-015021-pol2qm74	7395	25	peripheral	peripheral	JJ
cord-015021-pol2qm74	7395	26	blood	blood	NN
cord-015021-pol2qm74	7395	27	and	and	CC
cord-015021-pol2qm74	7395	28	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7395	29	fluid	fluid	NN
cord-015021-pol2qm74	7395	30	.	.	.
cord-015021-pol2qm74	7396	1	LPS	LPS	NNP
cord-015021-pol2qm74	7396	2	,	,	,
cord-015021-pol2qm74	7396	3	TNF	TNF	NNP
cord-015021-pol2qm74	7396	4	,	,	,
cord-015021-pol2qm74	7396	5	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	7396	6	21	21	CD
cord-015021-pol2qm74	7396	7	and	and	CC
cord-015021-pol2qm74	7396	8	Lactate	Lactate	NNP
cord-015021-pol2qm74	7396	9	were	be	VBD
cord-015021-pol2qm74	7396	10	measured	measure	VBN
cord-015021-pol2qm74	7396	11	in	in	IN
cord-015021-pol2qm74	7396	12	blood	blood	NN
cord-015021-pol2qm74	7396	13	from	from	IN
cord-015021-pol2qm74	7396	14	femoral	femoral	JJ
cord-015021-pol2qm74	7396	15	vein	vein	NN
cord-015021-pol2qm74	7396	16	.	.	.
cord-015021-pol2qm74	7397	1	Mortality	mortality	NN
cord-015021-pol2qm74	7397	2	rates	rate	NNS
cord-015021-pol2qm74	7397	3	were	be	VBD
cord-015021-pol2qm74	7397	4	registered	register	VBN
cord-015021-pol2qm74	7397	5	with	with	IN
cord-015021-pol2qm74	7397	6	G	G	NNP
cord-015021-pol2qm74	7397	7	-	-	HYPH
cord-015021-pol2qm74	7397	8	CSF	csf	NN
cord-015021-pol2qm74	7397	9	treatment	treatment	NN
cord-015021-pol2qm74	7397	10	starting	start	VBG
cord-015021-pol2qm74	7397	11	either	either	CC
cord-015021-pol2qm74	7397	12	1	1	CD
cord-015021-pol2qm74	7397	13	or	or	CC
cord-015021-pol2qm74	7397	14	7	7	CD
cord-015021-pol2qm74	7397	15	days	day	NNS
cord-015021-pol2qm74	7397	16	before	before	IN
cord-015021-pol2qm74	7397	17	or	or	CC
cord-015021-pol2qm74	7397	18	4	4	CD
cord-015021-pol2qm74	7397	19	hours	hour	NNS
cord-015021-pol2qm74	7397	20	after	after	IN
cord-015021-pol2qm74	7397	21	CP	cp	NN
cord-015021-pol2qm74	7397	22	.	.	.
cord-015021-pol2qm74	7398	1	Results	result	NNS
cord-015021-pol2qm74	7398	2	.	.	.
cord-015021-pol2qm74	7399	1	Mortality	mortality	NN
cord-015021-pol2qm74	7399	2	was	be	VBD
cord-015021-pol2qm74	7399	3	reduced	reduce	VBN
cord-015021-pol2qm74	7399	4	from	from	IN
cord-015021-pol2qm74	7399	5	90	90	CD
cord-015021-pol2qm74	7399	6	%	%	NN
cord-015021-pol2qm74	7399	7	to	to	IN
cord-015021-pol2qm74	7399	8	about	about	IN
cord-015021-pol2qm74	7399	9	50	50	CD
cord-015021-pol2qm74	7399	10	%	%	NN
cord-015021-pol2qm74	7399	11	with	with	IN
cord-015021-pol2qm74	7399	12	rhG	rhG	NNP
cord-015021-pol2qm74	7399	13	-	-	HYPH
cord-015021-pol2qm74	7399	14	CSF	csf	NN
cord-015021-pol2qm74	7399	15	intervention	intervention	NN
cord-015021-pol2qm74	7399	16	and	and	CC
cord-015021-pol2qm74	7399	17	there	there	EX
cord-015021-pol2qm74	7399	18	was	be	VBD
cord-015021-pol2qm74	7399	19	no	no	DT
cord-015021-pol2qm74	7399	20	difference	difference	NN
cord-015021-pol2qm74	7399	21	between	between	IN
cord-015021-pol2qm74	7399	22	the	the	DT
cord-015021-pol2qm74	7399	23	pretreatment	pretreatment	NN
cord-015021-pol2qm74	7399	24	and	and	CC
cord-015021-pol2qm74	7399	25	treatment	treatment	NN
cord-015021-pol2qm74	7399	26	groups	group	NNS
cord-015021-pol2qm74	7399	27	.	.	.
cord-015021-pol2qm74	7400	1	Bone	bone	NN
cord-015021-pol2qm74	7400	2	marrow	marrow	NN
cord-015021-pol2qm74	7400	3	blast	blast	NN
cord-015021-pol2qm74	7400	4	colonies	colony	NNS
cord-015021-pol2qm74	7400	5	were	be	VBD
cord-015021-pol2qm74	7400	6	not	not	RB
cord-015021-pol2qm74	7400	7	influenced	influence	VBN
cord-015021-pol2qm74	7400	8	while	while	IN
cord-015021-pol2qm74	7400	9	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7400	10	myelopoiesis	myelopoiesis	NNP
cord-015021-pol2qm74	7400	11	was	be	VBD
cord-015021-pol2qm74	7400	12	augmented	augment	VBN
cord-015021-pol2qm74	7400	13	at	at	IN
cord-015021-pol2qm74	7400	14	the	the	DT
cord-015021-pol2qm74	7400	15	stages	stage	NNS
cord-015021-pol2qm74	7400	16	of	of	IN
cord-015021-pol2qm74	7400	17	CFU	CFU	NNP
cord-015021-pol2qm74	7400	18	-	-	HYPH
cord-015021-pol2qm74	7400	19	GM	GM	NNP
cord-015021-pol2qm74	7400	20	and	and	CC
cord-015021-pol2qm74	7400	21	CFU	CFU	NNP
cord-015021-pol2qm74	7400	22	-	-	HYPH
cord-015021-pol2qm74	7400	23	G.	G.	NNP
cord-015021-pol2qm74	7400	24	Neutrophils	Neutrophils	NNPS
cord-015021-pol2qm74	7400	25	in	in	IN
cord-015021-pol2qm74	7400	26	blood	blood	NN
cord-015021-pol2qm74	7400	27	and	and	CC
cord-015021-pol2qm74	7400	28	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7400	29	cavity	cavity	NN
cord-015021-pol2qm74	7400	30	were	be	VBD
cord-015021-pol2qm74	7400	31	enhanced	enhance	VBN
cord-015021-pol2qm74	7400	32	and	and	CC
cord-015021-pol2qm74	7400	33	numbers	number	NNS
cord-015021-pol2qm74	7400	34	of	of	IN
cord-015021-pol2qm74	7400	35	bacteria	bacteria	NNS
cord-015021-pol2qm74	7400	36	in	in	IN
cord-015021-pol2qm74	7400	37	the	the	DT
cord-015021-pol2qm74	7400	38	same	same	JJ
cord-015021-pol2qm74	7400	39	compartments	compartment	NNS
cord-015021-pol2qm74	7400	40	were	be	VBD
cord-015021-pol2qm74	7400	41	substantially	substantially	RB
cord-015021-pol2qm74	7400	42	reduced	reduce	VBN
cord-015021-pol2qm74	7400	43	.	.	.
cord-015021-pol2qm74	7401	1	Circulating	circulate	VBG
cord-015021-pol2qm74	7401	2	LPS	LPS	NNP
cord-015021-pol2qm74	7401	3	,	,	,
cord-015021-pol2qm74	7401	4	TNF	TNF	NNP
cord-015021-pol2qm74	7401	5	,	,	,
cord-015021-pol2qm74	7401	6	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	7401	7	21	21	CD
cord-015021-pol2qm74	7401	8	and	and	CC
cord-015021-pol2qm74	7401	9	Lactate	Lactate	NNP
cord-015021-pol2qm74	7401	10	were	be	VBD
cord-015021-pol2qm74	7401	11	attenuated	attenuate	VBN
cord-015021-pol2qm74	7401	12	the	the	DT
cord-015021-pol2qm74	7401	13	first	first	JJ
cord-015021-pol2qm74	7401	14	24	24	CD
cord-015021-pol2qm74	7401	15	hours	hour	NNS
cord-015021-pol2qm74	7401	16	after	after	IN
cord-015021-pol2qm74	7401	17	CP	cp	NN
cord-015021-pol2qm74	7401	18	.	.	.
cord-015021-pol2qm74	7402	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	7402	2	myelopoiesis	myelopoiesis	NN
cord-015021-pol2qm74	7402	3	is	be	VBZ
cord-015021-pol2qm74	7402	4	augmented	augment	VBN
cord-015021-pol2qm74	7402	5	with	with	IN
cord-015021-pol2qm74	7402	6	increased	increase	VBN
cord-015021-pol2qm74	7402	7	number	number	NN
cord-015021-pol2qm74	7402	8	of	of	IN
cord-015021-pol2qm74	7402	9	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7402	10	in	in	IN
cord-015021-pol2qm74	7402	11	blood	blood	NN
cord-015021-pol2qm74	7402	12	and	and	CC
cord-015021-pol2qm74	7402	13	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	7402	14	cavity	cavity	NN
cord-015021-pol2qm74	7402	15	,	,	,
cord-015021-pol2qm74	7402	16	resulting	result	VBG
cord-015021-pol2qm74	7402	17	in	in	IN
cord-015021-pol2qm74	7402	18	enhanced	enhanced	JJ
cord-015021-pol2qm74	7402	19	clearance	clearance	NN
cord-015021-pol2qm74	7402	20	of	of	IN
cord-015021-pol2qm74	7402	21	pathogens	pathogen	NNS
cord-015021-pol2qm74	7402	22	.	.	.
cord-015021-pol2qm74	7403	1	LPS	LPS	NNP
cord-015021-pol2qm74	7403	2	,	,	,
cord-015021-pol2qm74	7403	3	TNF	TNF	NNP
cord-015021-pol2qm74	7403	4	,	,	,
cord-015021-pol2qm74	7403	5	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	7403	6	21	21	CD
cord-015021-pol2qm74	7403	7	and	and	CC
cord-015021-pol2qm74	7403	8	Lactate	Lactate	NNP
cord-015021-pol2qm74	7403	9	are	be	VBP
cord-015021-pol2qm74	7403	10	suppressed	suppress	VBN
cord-015021-pol2qm74	7403	11	the	the	DT
cord-015021-pol2qm74	7403	12	first	first	JJ
cord-015021-pol2qm74	7403	13	24	24	CD
cord-015021-pol2qm74	7403	14	hours	hour	NNS
cord-015021-pol2qm74	7403	15	during	during	IN
cord-015021-pol2qm74	7403	16	sepsis	sepsis	NN
cord-015021-pol2qm74	7403	17	course	course	NN
cord-015021-pol2qm74	7403	18	.	.	.
cord-015021-pol2qm74	7404	1	A.	A.	NNP
cord-015021-pol2qm74	7404	2	Wendel	Wendel	NNP
cord-015021-pol2qm74	7404	3	,	,	,
cord-015021-pol2qm74	7404	4	J.	J.	NNP
cord-015021-pol2qm74	7404	5	Barsig	Barsig	NNP
cord-015021-pol2qm74	7404	6	,	,	,
cord-015021-pol2qm74	7404	7	G.	G.	NNP
cord-015021-pol2qm74	7404	8	Tiegs	Tiegs	NNP
cord-015021-pol2qm74	7404	9	GM	GM	NNP
cord-015021-pol2qm74	7404	10	-	-	HYPH
cord-015021-pol2qm74	7404	11	CSF	CSF	NNP
cord-015021-pol2qm74	7404	12	stimulates	stimulate	VBZ
cord-015021-pol2qm74	7404	13	the	the	DT
cord-015021-pol2qm74	7404	14	proliferation	proliferation	NN
cord-015021-pol2qm74	7404	15	and	and	CC
cord-015021-pol2qm74	7404	16	differentiation	differentiation	NN
cord-015021-pol2qm74	7404	17	of	of	IN
cord-015021-pol2qm74	7404	18	granulocytic	granulocytic	JJ
cord-015021-pol2qm74	7404	19	and	and	CC
cord-015021-pol2qm74	7404	20	monocytic	monocytic	JJ
cord-015021-pol2qm74	7404	21	progenitor	progenitor	NN
cord-015021-pol2qm74	7404	22	cells	cell	NNS
cord-015021-pol2qm74	7404	23	.	.	.
cord-015021-pol2qm74	7405	1	In	in	IN
cord-015021-pol2qm74	7405	2	addition	addition	NN
cord-015021-pol2qm74	7405	3	the	the	DT
cord-015021-pol2qm74	7405	4	hemopoietic	hemopoietic	JJ
cord-015021-pol2qm74	7405	5	cytokine	cytokine	NN
cord-015021-pol2qm74	7405	6	activates	activate	VBZ
cord-015021-pol2qm74	7405	7	the	the	DT
cord-015021-pol2qm74	7405	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7405	9	response	response	NN
cord-015021-pol2qm74	7405	10	in	in	IN
cord-015021-pol2qm74	7405	11	mature	mature	JJ
cord-015021-pol2qm74	7405	12	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7405	13	.	.	.
cord-015021-pol2qm74	7406	1	The	the	DT
cord-015021-pol2qm74	7406	2	priming	prime	VBG
cord-015021-pol2qm74	7406	3	effect	effect	NN
cord-015021-pol2qm74	7406	4	of	of	IN
cord-015021-pol2qm74	7406	5	GM	GM	NNP
cord-015021-pol2qm74	7406	6	-	-	HYPH
cord-015021-pol2qm74	7406	7	CSF	CSF	NNP
cord-015021-pol2qm74	7406	8	towards	towards	IN
cord-015021-pol2qm74	7406	9	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	7406	10	(	(	-LRB-
cord-015021-pol2qm74	7406	11	LPS)-induced	lps)-induced	JJ
cord-015021-pol2qm74	7406	12	cytokine	cytokine	NN
cord-015021-pol2qm74	7406	13	production	production	NN
cord-015021-pol2qm74	7406	14	in	in	IN
cord-015021-pol2qm74	7406	15	vitro	vitro	FW
cord-015021-pol2qm74	7406	16	has	have	VBZ
cord-015021-pol2qm74	7406	17	been	be	VBN
cord-015021-pol2qm74	7406	18	described	describe	VBN
cord-015021-pol2qm74	7406	19	,	,	,
cord-015021-pol2qm74	7406	20	but	but	CC
cord-015021-pol2qm74	7406	21	little	little	JJ
cord-015021-pol2qm74	7406	22	is	be	VBZ
cord-015021-pol2qm74	7406	23	known	know	VBN
cord-015021-pol2qm74	7406	24	about	about	IN
cord-015021-pol2qm74	7406	25	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	7406	26	GM	GM	NNP
cord-015021-pol2qm74	7406	27	-	-	HYPH
cord-015021-pol2qm74	7406	28	CSF	csf	NN
cord-015021-pol2qm74	7406	29	effects	effect	NNS
cord-015021-pol2qm74	7406	30	in	in	IN
cord-015021-pol2qm74	7406	31	vivo	vivo	NN
cord-015021-pol2qm74	7406	32	.	.	.
cord-015021-pol2qm74	7407	1	We	-PRON-	PRP
cord-015021-pol2qm74	7407	2	detected	detect	VBD
cord-015021-pol2qm74	7407	3	GM	GM	NNP
cord-015021-pol2qm74	7407	4	-	-	HYPH
cord-015021-pol2qm74	7407	5	CSF	CSF	NNP
cord-015021-pol2qm74	7407	6	in	in	IN
cord-015021-pol2qm74	7407	7	plasma	plasma	NN
cord-015021-pol2qm74	7407	8	of	of	IN
cord-015021-pol2qm74	7407	9	LPS	LPS	NNP
cord-015021-pol2qm74	7407	10	-	-	HYPH
cord-015021-pol2qm74	7407	11	challenged	challenge	VBN
cord-015021-pol2qm74	7407	12	mice	mouse	NNS
cord-015021-pol2qm74	7407	13	with	with	IN
cord-015021-pol2qm74	7407	14	kinetics	kinetic	NNS
cord-015021-pol2qm74	7407	15	similar	similar	JJ
cord-015021-pol2qm74	7407	16	to	to	IN
cord-015021-pol2qm74	7407	17	TNF	TNF	NNP
cord-015021-pol2qm74	7407	18	,	,	,
cord-015021-pol2qm74	7407	19	reaching	reach	VBG
cord-015021-pol2qm74	7407	20	peak	peak	NN
cord-015021-pol2qm74	7407	21	levels	level	NNS
cord-015021-pol2qm74	7407	22	2h	2h	CD
cord-015021-pol2qm74	7407	23	after	after	IN
cord-015021-pol2qm74	7407	24	LPS	LPS	NNP
cord-015021-pol2qm74	7407	25	administration	administration	NN
cord-015021-pol2qm74	7407	26	.	.	.
cord-015021-pol2qm74	7408	1	GM	GM	NNP
cord-015021-pol2qm74	7408	2	-	-	HYPH
cord-015021-pol2qm74	7408	3	CSF	CSF	NNP
cord-015021-pol2qm74	7408	4	pretreatment	pretreatment	NN
cord-015021-pol2qm74	7408	5	(	(	-LRB-
cord-015021-pol2qm74	7408	6	50	50	CD
cord-015021-pol2qm74	7408	7	~tg	~tg	NNS
cord-015021-pol2qm74	7408	8	/	/	SYM
cord-015021-pol2qm74	7408	9	kg	kg	NNP
cord-015021-pol2qm74	7408	10	i.v	i.v	NNP
cord-015021-pol2qm74	7408	11	.	.	.
cord-015021-pol2qm74	7408	12	)	)	-RRB-
cord-015021-pol2qm74	7409	1	enhanced	enhanced	JJ
cord-015021-pol2qm74	7409	2	mortality	mortality	NN
cord-015021-pol2qm74	7409	3	in	in	IN
cord-015021-pol2qm74	7409	4	mice	mouse	NNS
cord-015021-pol2qm74	7409	5	challenged	challenge	VBN
cord-015021-pol2qm74	7409	6	by	by	IN
cord-015021-pol2qm74	7409	7	a	a	DT
cord-015021-pol2qm74	7409	8	sublethal	sublethal	JJ
cord-015021-pol2qm74	7409	9	dose	dose	NN
cord-015021-pol2qm74	7409	10	of	of	IN
cord-015021-pol2qm74	7409	11	LPS	LPS	NNP
cord-015021-pol2qm74	7409	12	.	.	.
cord-015021-pol2qm74	7410	1	Plasma	plasma	NN
cord-015021-pol2qm74	7410	2	levels	level	NNS
cord-015021-pol2qm74	7410	3	of	of	IN
cord-015021-pol2qm74	7410	4	Tumor	tumor	NN
cord-015021-pol2qm74	7410	5	Necrosis	necrosis	NN
cord-015021-pol2qm74	7410	6	Factor	factor	NN
cord-015021-pol2qm74	7410	7	(	(	-LRB-
cord-015021-pol2qm74	7410	8	TNF	TNF	NNP
cord-015021-pol2qm74	7410	9	)	)	-RRB-
cord-015021-pol2qm74	7410	10	and	and	CC
cord-015021-pol2qm74	7410	11	Interleukin-6	Interleukin-6	NNP
cord-015021-pol2qm74	7411	1	(	(	-LRB-
cord-015021-pol2qm74	7411	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	7411	3	)	)	-RRB-
cord-015021-pol2qm74	7411	4	were	be	VBD
cord-015021-pol2qm74	7411	5	significantly	significantly	RB
cord-015021-pol2qm74	7411	6	enhanced	enhance	VBN
cord-015021-pol2qm74	7411	7	.	.	.
cord-015021-pol2qm74	7412	1	A	a	DT
cord-015021-pol2qm74	7412	2	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7412	3	antibody	antibody	NN
cord-015021-pol2qm74	7412	4	,	,	,
cord-015021-pol2qm74	7412	5	which	which	WDT
cord-015021-pol2qm74	7412	6	neutralizes	neutralize	VBZ
cord-015021-pol2qm74	7412	7	GM	GM	NNP
cord-015021-pol2qm74	7412	8	-	-	HYPH
cord-015021-pol2qm74	7412	9	CSF	csf	NN
cord-015021-pol2qm74	7412	10	bioactivity	bioactivity	NN
cord-015021-pol2qm74	7412	11	,	,	,
cord-015021-pol2qm74	7412	12	rendered	render	VBN
cord-015021-pol2qm74	7412	13	mice	mouse	NNS
cord-015021-pol2qm74	7412	14	less	less	RBR
cord-015021-pol2qm74	7412	15	sensitive	sensitive	JJ
cord-015021-pol2qm74	7412	16	towards	towards	IN
cord-015021-pol2qm74	7412	17	lethal	lethal	JJ
cord-015021-pol2qm74	7412	18	LPS	LPS	NNP
cord-015021-pol2qm74	7412	19	-	-	HYPH
cord-015021-pol2qm74	7412	20	challenge	challenge	NN
cord-015021-pol2qm74	7412	21	.	.	.
cord-015021-pol2qm74	7413	1	TNF	TNF	NNP
cord-015021-pol2qm74	7413	2	-	-	HYPH
cord-015021-pol2qm74	7413	3	and	and	CC
cord-015021-pol2qm74	7413	4	IL-6-tevels	il-6-tevel	NNS
cord-015021-pol2qm74	7413	5	were	be	VBD
cord-015021-pol2qm74	7413	6	reduced	reduce	VBN
cord-015021-pol2qm74	7413	7	in	in	IN
cord-015021-pol2qm74	7413	8	these	these	DT
cord-015021-pol2qm74	7413	9	mice	mouse	NNS
cord-015021-pol2qm74	7413	10	compared	compare	VBN
cord-015021-pol2qm74	7413	11	to	to	TO
cord-015021-pol2qm74	7413	12	control	control	VB
cord-015021-pol2qm74	7413	13	animals	animal	NNS
cord-015021-pol2qm74	7413	14	without	without	IN
cord-015021-pol2qm74	7413	15	antibody	antibody	NN
cord-015021-pol2qm74	7413	16	treatment	treatment	NN
cord-015021-pol2qm74	7413	17	.	.	.
cord-015021-pol2qm74	7414	1	In	in	IN
cord-015021-pol2qm74	7414	2	addition	addition	NN
cord-015021-pol2qm74	7414	3	,	,	,
cord-015021-pol2qm74	7414	4	severalfold	severalfold	JJ
cord-015021-pol2qm74	7414	5	potentiation	potentiation	NN
cord-015021-pol2qm74	7414	6	of	of	IN
cord-015021-pol2qm74	7414	7	LPS	LPS	NNP
cord-015021-pol2qm74	7414	8	-	-	HYPH
cord-015021-pol2qm74	7414	9	induced	induce	VBN
cord-015021-pol2qm74	7414	10	cytokine	cytokine	NN
cord-015021-pol2qm74	7414	11	release	release	NN
cord-015021-pol2qm74	7414	12	by	by	IN
cord-015021-pol2qm74	7414	13	GM	GM	NNP
cord-015021-pol2qm74	7414	14	-	-	HYPH
cord-015021-pol2qm74	7414	15	CSF	CSF	NNP
cord-015021-pol2qm74	7414	16	was	be	VBD
cord-015021-pol2qm74	7414	17	observed	observe	VBN
cord-015021-pol2qm74	7414	18	in	in	IN
cord-015021-pol2qm74	7414	19	vitro	vitro	FW
cord-015021-pol2qm74	7414	20	in	in	IN
cord-015021-pol2qm74	7414	21	murine	murine	JJ
cord-015021-pol2qm74	7414	22	bone	bone	NN
cord-015021-pol2qm74	7414	23	marrow	marrow	NN
cord-015021-pol2qm74	7414	24	cell	cell	NN
cord-015021-pol2qm74	7414	25	cultures	culture	NNS
cord-015021-pol2qm74	7414	26	.	.	.
cord-015021-pol2qm74	7415	1	These	these	DT
cord-015021-pol2qm74	7415	2	data	datum	NNS
cord-015021-pol2qm74	7415	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	7415	4	the	the	DT
cord-015021-pol2qm74	7415	5	proinflammatory	proinflammatory	JJ
cord-015021-pol2qm74	7415	6	capacity	capacity	NN
cord-015021-pol2qm74	7415	7	of	of	IN
cord-015021-pol2qm74	7415	8	GM	GM	NNP
cord-015021-pol2qm74	7415	9	-	-	HYPH
cord-015021-pol2qm74	7415	10	CSF	CSF	NNP
cord-015021-pol2qm74	7415	11	and	and	CC
cord-015021-pol2qm74	7415	12	suggest	suggest	VBP
cord-015021-pol2qm74	7415	13	that	that	IN
cord-015021-pol2qm74	7415	14	the	the	DT
cord-015021-pol2qm74	7415	15	hemopoietic	hemopoietic	JJ
cord-015021-pol2qm74	7415	16	cytokine	cytokine	NN
cord-015021-pol2qm74	7415	17	plays	play	VBZ
cord-015021-pol2qm74	7415	18	also	also	RB
cord-015021-pol2qm74	7415	19	a	a	DT
cord-015021-pol2qm74	7415	20	role	role	NN
cord-015021-pol2qm74	7415	21	as	as	IN
cord-015021-pol2qm74	7415	22	an	an	DT
cord-015021-pol2qm74	7415	23	endogenous	endogenous	JJ
cord-015021-pol2qm74	7415	24	modulator	modulator	NN
cord-015021-pol2qm74	7415	25	of	of	IN
cord-015021-pol2qm74	7415	26	LPS	LPS	NNP
cord-015021-pol2qm74	7415	27	toxicity	toxicity	NN
cord-015021-pol2qm74	7415	28	.	.	.
cord-015021-pol2qm74	7416	1	Immune	immune	JJ
cord-015021-pol2qm74	7416	2	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7416	3	,	,	,
cord-015021-pol2qm74	7416	4	developing	develop	VBG
cord-015021-pol2qm74	7416	5	in	in	IN
cord-015021-pol2qm74	7416	6	the	the	DT
cord-015021-pol2qm74	7416	7	wake	wake	NN
cord-015021-pol2qm74	7416	8	of	of	IN
cord-015021-pol2qm74	7416	9	multiple	multiple	JJ
cord-015021-pol2qm74	7416	10	trauma	trauma	NN
cord-015021-pol2qm74	7416	11	,	,	,
cord-015021-pol2qm74	7416	12	overwhelming	overwhelming	JJ
cord-015021-pol2qm74	7416	13	infection	infection	NN
cord-015021-pol2qm74	7416	14	and	and	CC
cord-015021-pol2qm74	7416	15	other	other	JJ
cord-015021-pol2qm74	7416	16	forms	form	NNS
cord-015021-pol2qm74	7416	17	of	of	IN
cord-015021-pol2qm74	7416	18	critical	critical	JJ
cord-015021-pol2qm74	7416	19	surgical	surgical	JJ
cord-015021-pol2qm74	7416	20	illnes%	illnes%	NN
cord-015021-pol2qm74	7416	21	is	be	VBZ
cord-015021-pol2qm74	7416	22	associated	associate	VBN
cord-015021-pol2qm74	7416	23	with	with	IN
cord-015021-pol2qm74	7416	24	increased	increase	VBN
cord-015021-pol2qm74	7416	25	infections	infection	NNS
cord-015021-pol2qm74	7416	26	,	,	,
cord-015021-pol2qm74	7416	27	morbidity	morbidity	NN
cord-015021-pol2qm74	7416	28	and	and	CC
cord-015021-pol2qm74	7416	29	mortality	mortality	NN
cord-015021-pol2qm74	7416	30	.	.	.
cord-015021-pol2qm74	7417	1	The	the	DT
cord-015021-pol2qm74	7417	2	mechanisms	mechanism	NNS
cord-015021-pol2qm74	7417	3	responsible	responsible	JJ
cord-015021-pol2qm74	7417	4	for	for	IN
cord-015021-pol2qm74	7417	5	alterations	alteration	NNS
cord-015021-pol2qm74	7417	6	in	in	IN
cord-015021-pol2qm74	7417	7	immune	immune	JJ
cord-015021-pol2qm74	7417	8	regulation	regulation	NN
cord-015021-pol2qm74	7417	9	are	be	VBP
cord-015021-pol2qm74	7417	10	incompletely	incompletely	RB
cord-015021-pol2qm74	7417	11	understood	understand	VBN
cord-015021-pol2qm74	7417	12	but	but	CC
cord-015021-pol2qm74	7417	13	monocyte	monocyte	NNP
cord-015021-pol2qm74	7417	14	appear	appear	VBP
cord-015021-pol2qm74	7417	15	to	to	TO
cord-015021-pol2qm74	7417	16	play	play	VB
cord-015021-pol2qm74	7417	17	a	a	DT
cord-015021-pol2qm74	7417	18	central	central	JJ
cord-015021-pol2qm74	7417	19	role	role	NN
cord-015021-pol2qm74	7417	20	.	.	.
cord-015021-pol2qm74	7418	1	Polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	7418	2	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7418	3	(	(	-LRB-
cord-015021-pol2qm74	7418	4	PMN	PMN	NNP
cord-015021-pol2qm74	7418	5	)	)	-RRB-
cord-015021-pol2qm74	7418	6	are	be	VBP
cord-015021-pol2qm74	7418	7	known	know	VBN
cord-015021-pol2qm74	7418	8	to	to	TO
cord-015021-pol2qm74	7418	9	play	play	VB
cord-015021-pol2qm74	7418	10	a	a	DT
cord-015021-pol2qm74	7418	11	central	central	JJ
cord-015021-pol2qm74	7418	12	role	role	NN
cord-015021-pol2qm74	7418	13	in	in	IN
cord-015021-pol2qm74	7418	14	the	the	DT
cord-015021-pol2qm74	7418	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7418	16	response	response	NN
cord-015021-pol2qm74	7418	17	of	of	IN
cord-015021-pol2qm74	7418	18	the	the	DT
cord-015021-pol2qm74	7418	19	host	host	NN
cord-015021-pol2qm74	7418	20	toward	toward	IN
cord-015021-pol2qm74	7418	21	invading	invade	VBG
cord-015021-pol2qm74	7418	22	microrganisms	microrganism	NNS
cord-015021-pol2qm74	7418	23	.	.	.
cord-015021-pol2qm74	7419	1	Reports	report	NNS
cord-015021-pol2qm74	7419	2	of	of	IN
cord-015021-pol2qm74	7419	3	defects	defect	NNS
cord-015021-pol2qm74	7419	4	in	in	IN
cord-015021-pol2qm74	7419	5	all	all	PDT
cord-015021-pol2qm74	7419	6	the	the	DT
cord-015021-pol2qm74	7419	7	aspeots	aspeot	NNS
cord-015021-pol2qm74	7419	8	of	of	IN
cord-015021-pol2qm74	7419	9	PMN	PMN	NNP
cord-015021-pol2qm74	7419	10	function	function	NN
cord-015021-pol2qm74	7419	11	have	have	VBP
cord-015021-pol2qm74	7419	12	been	be	VBN
cord-015021-pol2qm74	7419	13	accumulated	accumulate	VBN
cord-015021-pol2qm74	7419	14	in	in	IN
cord-015021-pol2qm74	7419	15	recent	recent	JJ
cord-015021-pol2qm74	7419	16	years	year	NNS
cord-015021-pol2qm74	7419	17	.	.	.
cord-015021-pol2qm74	7420	1	The	the	DT
cord-015021-pol2qm74	7420	2	possible	possible	JJ
cord-015021-pol2qm74	7420	3	role	role	NN
cord-015021-pol2qm74	7420	4	of	of	IN
cord-015021-pol2qm74	7420	5	GM	GM	NNP
cord-015021-pol2qm74	7420	6	-	-	HYPH
cord-015021-pol2qm74	7420	7	CSF	CSF	NNP
cord-015021-pol2qm74	7420	8	in	in	IN
cord-015021-pol2qm74	7420	9	modifing	modife	VBG
cord-015021-pol2qm74	7420	10	the	the	DT
cord-015021-pol2qm74	7420	11	state	state	NN
cord-015021-pol2qm74	7420	12	of	of	IN
cord-015021-pol2qm74	7420	13	immuno	immuno	JJ
cord-015021-pol2qm74	7420	14	suppression	suppression	NN
cord-015021-pol2qm74	7420	15	detected	detect	VBN
cord-015021-pol2qm74	7420	16	in	in	IN
cord-015021-pol2qm74	7420	17	severe	severe	JJ
cord-015021-pol2qm74	7420	18	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	7420	19	infected	infected	JJ
cord-015021-pol2qm74	7420	20	pt~.	pt~.	JJ
cord-015021-pol2qm74	7420	21	inspite	inspite	NN
cord-015021-pol2qm74	7420	22	of	of	IN
cord-015021-pol2qm74	7420	23	surgical	surgical	JJ
cord-015021-pol2qm74	7420	24	appropriate	appropriate	JJ
cord-015021-pol2qm74	7420	25	procedures	procedure	NNS
cord-015021-pol2qm74	7420	26	and	and	CC
cord-015021-pol2qm74	7420	27	in	in	IN
cord-015021-pol2qm74	7420	28	reducing	reduce	VBG
cord-015021-pol2qm74	7420	29	the	the	DT
cord-015021-pol2qm74	7420	30	expected	expect	VBN
cord-015021-pol2qm74	7420	31	mortality	mortality	NN
cord-015021-pol2qm74	7420	32	is	be	VBZ
cord-015021-pol2qm74	7420	33	investigated	investigate	VBN
cord-015021-pol2qm74	7420	34	.	.	.
cord-015021-pol2qm74	7421	1	The	the	DT
cord-015021-pol2qm74	7421	2	safety	safety	NN
cord-015021-pol2qm74	7421	3	of	of	IN
cord-015021-pol2qm74	7421	4	rh	rh	NNP
cord-015021-pol2qm74	7421	5	-	-	HYPH
cord-015021-pol2qm74	7421	6	GM	GM	NNP
cord-015021-pol2qm74	7421	7	-	-	HYPH
cord-015021-pol2qm74	7421	8	CSF	CSF	NNP
cord-015021-pol2qm74	7421	9	administration	administration	NN
cord-015021-pol2qm74	7421	10	in	in	IN
cord-015021-pol2qm74	7421	11	sepsis	sepsis	NN
cord-015021-pol2qm74	7421	12	is	be	VBZ
cord-015021-pol2qm74	7421	13	also	also	RB
cord-015021-pol2qm74	7421	14	evaluated	evaluate	VBN
cord-015021-pol2qm74	7421	15	.	.	.
cord-015021-pol2qm74	7422	1	A	a	DT
cord-015021-pol2qm74	7422	2	double	double	JJ
cord-015021-pol2qm74	7422	3	blind	blind	JJ
cord-015021-pol2qm74	7422	4	randomized	randomized	JJ
cord-015021-pol2qm74	7422	5	study	study	NN
cord-015021-pol2qm74	7422	6	is	be	VBZ
cord-015021-pol2qm74	7422	7	proposed	propose	VBN
cord-015021-pol2qm74	7422	8	.	.	.
cord-015021-pol2qm74	7423	1	This	this	DT
cord-015021-pol2qm74	7423	2	study	study	NN
cord-015021-pol2qm74	7423	3	include	include	VBP
cord-015021-pol2qm74	7423	4	60	60	CD
cord-015021-pol2qm74	7423	5	ICU	ICU	NNP
cord-015021-pol2qm74	7423	6	patients	patient	NNS
cord-015021-pol2qm74	7423	7	who	who	WP
cord-015021-pol2qm74	7423	8	do	do	VBP
cord-015021-pol2qm74	7423	9	not	not	RB
cord-015021-pol2qm74	7423	10	exhibit	exhibit	VB
cord-015021-pol2qm74	7423	11	signs	sign	NNS
cord-015021-pol2qm74	7423	12	of	of	IN
cord-015021-pol2qm74	7423	13	shock	shock	NN
cord-015021-pol2qm74	7423	14	and/or	and/or	CC
cord-015021-pol2qm74	7423	15	ARDS	ARDS	NNP
cord-015021-pol2qm74	7423	16	,	,	,
cord-015021-pol2qm74	7423	17	with	with	IN
cord-015021-pol2qm74	7423	18	clinical	clinical	JJ
cord-015021-pol2qm74	7423	19	signs	sign	NNS
cord-015021-pol2qm74	7423	20	and	and	CC
cord-015021-pol2qm74	7423	21	symptoms	symptom	NNS
cord-015021-pol2qm74	7423	22	of	of	IN
cord-015021-pol2qm74	7423	23	abdominal	abdominal	JJ
cord-015021-pol2qm74	7423	24	infection	infection	NN
cord-015021-pol2qm74	7423	25	.	.	.
cord-015021-pol2qm74	7424	1	Immunodepressed	immunodepressed	JJ
cord-015021-pol2qm74	7424	2	patients	patient	NNS
cord-015021-pol2qm74	7424	3	-	-	HYPH
cord-015021-pol2qm74	7424	4	AIDS	AIDS	NNP
cord-015021-pol2qm74	7424	5	,	,	,
cord-015021-pol2qm74	7424	6	Chronic	chronic	JJ
cord-015021-pol2qm74	7424	7	chemotherapy	chemotherapy	NN
cord-015021-pol2qm74	7424	8	or	or	CC
cord-015021-pol2qm74	7424	9	chronic	chronic	JJ
cord-015021-pol2qm74	7424	10	steroid	steroid	NN
cord-015021-pol2qm74	7424	11	administration	administration	NN
cord-015021-pol2qm74	7424	12	do	do	VBP
cord-015021-pol2qm74	7424	13	not	not	RB
cord-015021-pol2qm74	7424	14	partecipate	partecipate	VB
cord-015021-pol2qm74	7424	15	to	to	IN
cord-015021-pol2qm74	7424	16	the	the	DT
cord-015021-pol2qm74	7424	17	study	study	NN
cord-015021-pol2qm74	7424	18	.	.	.
cord-015021-pol2qm74	7425	1	Patients	patient	NNS
cord-015021-pol2qm74	7425	2	will	will	MD
cord-015021-pol2qm74	7425	3	receive	receive	VB
cord-015021-pol2qm74	7425	4	rGM	rGM	VBN
cord-015021-pol2qm74	7425	5	-	-	HYPH
cord-015021-pol2qm74	7425	6	CSF	csf	NN
cord-015021-pol2qm74	7425	7	(	(	-LRB-
cord-015021-pol2qm74	7425	8	l	l	NN
cord-015021-pol2qm74	7425	9	~	~	CD
cord-015021-pol2qm74	7425	10	g	g	NN
cord-015021-pol2qm74	7425	11	/	/	SYM
cord-015021-pol2qm74	7425	12	Kg	Kg	NNP
cord-015021-pol2qm74	7425	13	/	/	SYM
cord-015021-pol2qm74	7425	14	day	day	NN
cord-015021-pol2qm74	7425	15	)	)	-RRB-
cord-015021-pol2qm74	7425	16	or	or	CC
cord-015021-pol2qm74	7425	17	placebo	placebo	NN
cord-015021-pol2qm74	7425	18	in	in	IN
cord-015021-pol2qm74	7425	19	24	24	CD
cord-015021-pol2qm74	7425	20	hs	hs	NNP
cord-015021-pol2qm74	7425	21	.	.	.
cord-015021-pol2qm74	7426	1	continuous	continuous	JJ
cord-015021-pol2qm74	7426	2	infusion	infusion	NN
cord-015021-pol2qm74	7426	3	for	for	IN
cord-015021-pol2qm74	7426	4	15	15	CD
cord-015021-pol2qm74	7426	5	days	day	NNS
cord-015021-pol2qm74	7426	6	.	.	.
cord-015021-pol2qm74	7427	1	SafetyandefYieacy	SafetyandefYieacy	NNP
cord-015021-pol2qm74	7427	2	will	will	MD
cord-015021-pol2qm74	7427	3	be	be	VB
cord-015021-pol2qm74	7427	4	assessed	assess	VBN
cord-015021-pol2qm74	7427	5	till	till	IN
cord-015021-pol2qm74	7427	6	to	to	IN
cord-015021-pol2qm74	7427	7	Day	Day	NNP
cord-015021-pol2qm74	7427	8	30	30	CD
cord-015021-pol2qm74	7427	9	.	.	.
cord-015021-pol2qm74	7428	1	The	the	DT
cord-015021-pol2qm74	7428	2	APACHE	APACHE	NNP
cord-015021-pol2qm74	7428	3	II	II	NNP
cord-015021-pol2qm74	7428	4	Score	Score	NNP
cord-015021-pol2qm74	7428	5	is	be	VBZ
cord-015021-pol2qm74	7428	6	adopted	adopt	VBN
cord-015021-pol2qm74	7428	7	for	for	IN
cord-015021-pol2qm74	7428	8	risk	risk	NN
cord-015021-pol2qm74	7428	9	stratification	stratification	NN
cord-015021-pol2qm74	7428	10	of	of	IN
cord-015021-pol2qm74	7428	11	patients	patient	NNS
cord-015021-pol2qm74	7428	12	because	because	IN
cord-015021-pol2qm74	7428	13	it	-PRON-	PRP
cord-015021-pol2qm74	7428	14	is	be	VBZ
cord-015021-pol2qm74	7428	15	reliable	reliable	JJ
cord-015021-pol2qm74	7428	16	and	and	CC
cord-015021-pol2qm74	7428	17	validated	validated	JJ
cord-015021-pol2qm74	7428	18	,	,	,
cord-015021-pol2qm74	7428	19	objective	objective	JJ
cord-015021-pol2qm74	7428	20	and	and	CC
cord-015021-pol2qm74	7428	21	composed	compose	VBN
cord-015021-pol2qm74	7428	22	of	of	IN
cord-015021-pol2qm74	7428	23	information	information	NN
cord-015021-pol2qm74	7428	24	that	that	WDT
cord-015021-pol2qm74	7428	25	is	be	VBZ
cord-015021-pol2qm74	7428	26	indipendent	indipendent	JJ
cord-015021-pol2qm74	7428	27	of	of	IN
cord-015021-pol2qm74	7428	28	diagnostic	diagnostic	JJ
cord-015021-pol2qm74	7428	29	criteria	criterion	NNS
cord-015021-pol2qm74	7428	30	.	.	.
cord-015021-pol2qm74	7429	1	Patient	Patient	NNP
cord-015021-pol2qm74	7429	2	's	's	POS
cord-015021-pol2qm74	7429	3	entry	entry	NN
cord-015021-pol2qm74	7429	4	criteria	criterion	NNS
cord-015021-pol2qm74	7429	5	is	be	VBZ
cord-015021-pol2qm74	7429	6	APACHE	APACHE	NNP
cord-015021-pol2qm74	7429	7	II	II	NNP
cord-015021-pol2qm74	7430	1	>	>	XX
cord-015021-pol2qm74	7431	1	16	16	CD
cord-015021-pol2qm74	7431	2	(	(	-LRB-
cord-015021-pol2qm74	7431	3	Score	score	NN
cord-015021-pol2qm74	7431	4	16	16	CD
cord-015021-pol2qm74	7431	5	corresponds	correspond	VBZ
cord-015021-pol2qm74	7431	6	to	to	IN
cord-015021-pol2qm74	7431	7	expected	expect	VBN
cord-015021-pol2qm74	7431	8	mortality	mortality	NN
cord-015021-pol2qm74	7431	9	rate	rate	NN
cord-015021-pol2qm74	7431	10	of	of	IN
cord-015021-pol2qm74	7431	11	38%).In	38%).in	CD
cord-015021-pol2qm74	7431	12	this	this	DT
cord-015021-pol2qm74	7431	13	protocol	protocol	NN
cord-015021-pol2qm74	7432	1	the	the	DT
cord-015021-pol2qm74	7432	2	surgeons	surgeon	NNS
cord-015021-pol2qm74	7432	3	report	report	VBP
cord-015021-pol2qm74	7432	4	the	the	DT
cord-015021-pol2qm74	7432	5	judgement	judgement	NN
cord-015021-pol2qm74	7432	6	of	of	IN
cord-015021-pol2qm74	7432	7	the	the	DT
cord-015021-pol2qm74	7432	8	efficacy	efficacy	NN
cord-015021-pol2qm74	7432	9	of	of	IN
cord-015021-pol2qm74	7432	10	surgical	surgical	JJ
cord-015021-pol2qm74	7432	11	procedure	procedure	NN
cord-015021-pol2qm74	7432	12	to	to	TO
cord-015021-pol2qm74	7432	13	remove	remove	VB
cord-015021-pol2qm74	7432	14	or	or	CC
cord-015021-pol2qm74	7432	15	not	not	RB
cord-015021-pol2qm74	7432	16	the	the	DT
cord-015021-pol2qm74	7432	17	focus	focus	NN
cord-015021-pol2qm74	7432	18	of	of	IN
cord-015021-pol2qm74	7432	19	infection	infection	NN
cord-015021-pol2qm74	7432	20	.	.	.
cord-015021-pol2qm74	7433	1	Objectives	objective	NNS
cord-015021-pol2qm74	7433	2	:	:	:
cord-015021-pol2qm74	7433	3	Infections	infection	NNS
cord-015021-pol2qm74	7433	4	and	and	CC
cord-015021-pol2qm74	7433	5	subsequent	subsequent	JJ
cord-015021-pol2qm74	7433	6	septic	septic	JJ
cord-015021-pol2qm74	7433	7	responses	response	NNS
cord-015021-pol2qm74	7433	8	remain	remain	VBP
cord-015021-pol2qm74	7433	9	the	the	DT
cord-015021-pol2qm74	7433	10	leading	leading	JJ
cord-015021-pol2qm74	7433	11	cause	cause	NN
cord-015021-pol2qm74	7433	12	of	of	IN
cord-015021-pol2qm74	7433	13	death	death	NN
cord-015021-pol2qm74	7433	14	among	among	IN
cord-015021-pol2qm74	7433	15	surgical	surgical	JJ
cord-015021-pol2qm74	7433	16	intensive	intensive	JJ
cord-015021-pol2qm74	7433	17	care	care	NN
cord-015021-pol2qm74	7433	18	(	(	-LRB-
cord-015021-pol2qm74	7433	19	SICU	SICU	NNP
cord-015021-pol2qm74	7433	20	)	)	-RRB-
cord-015021-pol2qm74	7433	21	patients	patient	NNS
cord-015021-pol2qm74	7433	22	despite	despite	IN
cord-015021-pol2qm74	7433	23	tmprovetaunts	tmprovetaunt	NNS
cord-015021-pol2qm74	7433	24	in	in	IN
cord-015021-pol2qm74	7433	25	supportive	supportive	JJ
cord-015021-pol2qm74	7433	26	care	care	NN
cord-015021-pol2qm74	7433	27	and	and	CC
cord-015021-pol2qm74	7433	28	brond	brond	NNP
cord-015021-pol2qm74	7433	29	-	-	HYPH
cord-015021-pol2qm74	7433	30	epectrum	epectrum	NN
cord-015021-pol2qm74	7433	31	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	7433	32	.	.	.
cord-015021-pol2qm74	7434	1	Usually	usually	RB
cord-015021-pol2qm74	7434	2	invading	invade	VBG
cord-015021-pol2qm74	7434	3	bacteria	bacteria	NNS
cord-015021-pol2qm74	7434	4	are	be	VBP
cord-015021-pol2qm74	7434	5	efficiently	efficiently	RB
cord-015021-pol2qm74	7434	6	cleared	clear	VBN
cord-015021-pol2qm74	7434	7	by	by	IN
cord-015021-pol2qm74	7434	8	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7434	9	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	7434	10	.	.	.
cord-015021-pol2qm74	7435	1	However	however	RB
cord-015021-pol2qm74	7435	2	,	,	,
cord-015021-pol2qm74	7435	3	during	during	IN
cord-015021-pol2qm74	7435	4	sepsis	sepsis	NN
cord-015021-pol2qm74	7435	5	various	various	JJ
cord-015021-pol2qm74	7435	6	neatrophil	neatrophil	NN
cord-015021-pol2qm74	7435	7	dysfunctions	dysfunction	NNS
cord-015021-pol2qm74	7435	8	have	have	VBP
cord-015021-pol2qm74	7435	9	been	be	VBN
cord-015021-pol2qm74	7435	10	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7435	11	,	,	,
cord-015021-pol2qm74	7435	12	leading	lead	VBG
cord-015021-pol2qm74	7435	13	to	to	IN
cord-015021-pol2qm74	7435	14	impaired	impaired	JJ
cord-015021-pol2qm74	7435	15	host	host	NN
cord-015021-pol2qm74	7435	16	defense	defense	NN
cord-015021-pol2qm74	7435	17	.	.	.
cord-015021-pol2qm74	7436	1	Granulocyte	Granulocyte	NNP
cord-015021-pol2qm74	7436	2	colony	colony	NN
cord-015021-pol2qm74	7436	3	-	-	HYPH
cord-015021-pol2qm74	7436	4	stimulating	stimulate	VBG
cord-015021-pol2qm74	7436	5	factor	factor	NN
cord-015021-pol2qm74	7436	6	(	(	-LRB-
cord-015021-pol2qm74	7436	7	G	G	NNP
cord-015021-pol2qm74	7436	8	-	-	HYPH
cord-015021-pol2qm74	7436	9	CSF	CSF	NNP
cord-015021-pol2qm74	7436	10	)	)	-RRB-
cord-015021-pol2qm74	7436	11	induces	induce	VBZ
cord-015021-pol2qm74	7436	12	a	a	DT
cord-015021-pol2qm74	7436	13	sustained	sustained	JJ
cord-015021-pol2qm74	7436	14	increase	increase	NN
cord-015021-pol2qm74	7436	15	in	in	IN
cord-015021-pol2qm74	7436	16	circulating	circulate	VBG
cord-015021-pol2qm74	7436	17	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7436	18	and	and	CC
cord-015021-pol2qm74	7436	19	enhances	enhance	VBZ
cord-015021-pol2qm74	7436	20	various	various	JJ
cord-015021-pol2qm74	7436	21	noutrophil	noutrophil	NNP
cord-015021-pol2qm74	7436	22	functions	function	NNS
cord-015021-pol2qm74	7436	23	.	.	.
cord-015021-pol2qm74	7437	1	It	-PRON-	PRP
cord-015021-pol2qm74	7437	2	was	be	VBD
cord-015021-pol2qm74	7437	3	the	the	DT
cord-015021-pol2qm74	7437	4	purpose	purpose	NN
cord-015021-pol2qm74	7437	5	of	of	IN
cord-015021-pol2qm74	7437	6	the	the	DT
cord-015021-pol2qm74	7437	7	present	present	JJ
cord-015021-pol2qm74	7437	8	study	study	NN
cord-015021-pol2qm74	7437	9	,	,	,
cord-015021-pol2qm74	7437	10	to	to	TO
cord-015021-pol2qm74	7437	11	evaluate	evaluate	VB
cord-015021-pol2qm74	7437	12	the	the	DT
cord-015021-pol2qm74	7437	13	safety	safety	NN
cord-015021-pol2qm74	7437	14	and	and	CC
cord-015021-pol2qm74	7437	15	efficacy	efficacy	NN
cord-015021-pol2qm74	7437	16	of	of	IN
cord-015021-pol2qm74	7437	17	G	G	NNP
cord-015021-pol2qm74	7437	18	-	-	HYPH
cord-015021-pol2qm74	7437	19	CSF	CSF	NNP
cord-015021-pol2qm74	7437	20	(	(	-LRB-
cord-015021-pol2qm74	7437	21	filgrastim	filgrastim	NNP
cord-015021-pol2qm74	7437	22	)	)	-RRB-
cord-015021-pol2qm74	7437	23	in	in	IN
cord-015021-pol2qm74	7437	24	SICU	SICU	NNP
cord-015021-pol2qm74	7437	25	patients	patient	NNS
cord-015021-pol2qm74	7437	26	at	at	IN
cord-015021-pol2qm74	7437	27	risk	risk	NN
cord-015021-pol2qm74	7437	28	of	of	IN
cord-015021-pol2qm74	7437	29	sepsis	sepsis	NN
cord-015021-pol2qm74	7437	30	.	.	.
cord-015021-pol2qm74	7438	1	Materiel	Materiel	NNP
cord-015021-pol2qm74	7438	2	a.d	a.d	NNP
cord-015021-pol2qm74	7438	3	Methods	Methods	NNPS
cord-015021-pol2qm74	7438	4	:	:	:
cord-015021-pol2qm74	7438	5	The	the	DT
cord-015021-pol2qm74	7438	6	study	study	NN
cord-015021-pol2qm74	7438	7	was	be	VBD
cord-015021-pol2qm74	7438	8	designed	design	VBN
cord-015021-pol2qm74	7438	9	as	as	IN
cord-015021-pol2qm74	7438	10	an	an	DT
cord-015021-pol2qm74	7438	11	open	open	JJ
cord-015021-pol2qm74	7438	12	-	-	HYPH
cord-015021-pol2qm74	7438	13	label	label	NN
cord-015021-pol2qm74	7438	14	phase	phase	NN
cord-015021-pol2qm74	7438	15	-	-	HYPH
cord-015021-pol2qm74	7438	16	ll	ll	JJ
cord-015021-pol2qm74	7438	17	study	study	NN
cord-015021-pol2qm74	7438	18	of	of	IN
cord-015021-pol2qm74	7438	19	filgrastim	filgrastim	NNP
cord-015021-pol2qm74	7438	20	.	.	.
cord-015021-pol2qm74	7439	1	Ten	ten	CD
cord-015021-pol2qm74	7439	2	consecutive	consecutive	JJ
cord-015021-pol2qm74	7439	3	SlCU	SlCU	NNP
cord-015021-pol2qm74	7439	4	patients	patient	NNS
cord-015021-pol2qm74	7439	5	,	,	,
cord-015021-pol2qm74	7439	6	with	with	IN
cord-015021-pol2qm74	7439	7	a	a	DT
cord-015021-pol2qm74	7439	8	Therapeutic	Therapeutic	NNP
cord-015021-pol2qm74	7439	9	Interveotion	Interveotion	NNP
cord-015021-pol2qm74	7439	10	Score	score	NN
cord-015021-pol2qm74	7439	11	greater	great	JJR
cord-015021-pol2qm74	7439	12	than	than	IN
cord-015021-pol2qm74	7439	13	30	30	CD
cord-015021-pol2qm74	7439	14	,	,	,
cord-015021-pol2qm74	7439	15	were	be	VBD
cord-015021-pol2qm74	7439	16	included	include	VBN
cord-015021-pol2qm74	7439	17	in	in	IN
cord-015021-pol2qm74	7439	18	the	the	DT
cord-015021-pol2qm74	7439	19	study	study	NN
cord-015021-pol2qm74	7439	20	.	.	.
cord-015021-pol2qm74	7440	1	Filgrastim	Filgrastim	NNP
cord-015021-pol2qm74	7440	2	was	be	VBD
cord-015021-pol2qm74	7440	3	given	give	VBN
cord-015021-pol2qm74	7440	4	by	by	IN
cord-015021-pol2qm74	7440	5	daily	daily	JJ
cord-015021-pol2qm74	7440	6	continuous	continuous	JJ
cord-015021-pol2qm74	7440	7	intravenous	intravenous	JJ
cord-015021-pol2qm74	7440	8	infusion	infusion	NN
cord-015021-pol2qm74	7440	9	for	for	IN
cord-015021-pol2qm74	7440	10	7	7	CD
cord-015021-pol2qm74	7440	11	days	day	NNS
cord-015021-pol2qm74	7440	12	or	or	CC
cord-015021-pol2qm74	7440	13	discharge	discharge	VB
cord-015021-pol2qm74	7440	14	from	from	IN
cord-015021-pol2qm74	7440	15	the	the	DT
cord-015021-pol2qm74	7440	16	SICU	SICU	NNP
cord-015021-pol2qm74	7440	17	.	.	.
cord-015021-pol2qm74	7441	1	APACHE	APACHE	NNP
cord-015021-pol2qm74	7441	2	ll	ll	NNP
cord-015021-pol2qm74	7441	3	-	-	HYPH
cord-015021-pol2qm74	7441	4	score	score	NN
cord-015021-pol2qm74	7441	5	,	,	,
cord-015021-pol2qm74	7441	6	multiple	multiple	JJ
cord-015021-pol2qm74	7441	7	-	-	HYPH
cord-015021-pol2qm74	7441	8	organ	organ	NN
cord-015021-pol2qm74	7441	9	-	-	HYPH
cord-015021-pol2qm74	7441	10	failure	failure	NN
cord-015021-pol2qm74	7441	11	(	(	-LRB-
cord-015021-pol2qm74	7441	12	MOF	MOF	NNP
cord-015021-pol2qm74	7441	13	)	)	-RRB-
cord-015021-pol2qm74	7441	14	score	score	NN
cord-015021-pol2qm74	7441	15	,	,	,
cord-015021-pol2qm74	7441	16	definitions	definition	NNS
cord-015021-pol2qm74	7441	17	of	of	IN
cord-015021-pol2qm74	7441	18	infections	infection	NNS
cord-015021-pol2qm74	7441	19	,	,	,
cord-015021-pol2qm74	7441	20	sepsis	sepsis	NN
cord-015021-pol2qm74	7441	21	,	,	,
cord-015021-pol2qm74	7441	22	systemic	systemic	JJ
cord-015021-pol2qm74	7441	23	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7441	24	response	response	NN
cord-015021-pol2qm74	7441	25	syndrome	syndrome	NN
cord-015021-pol2qm74	7441	26	(	(	-LRB-
cord-015021-pol2qm74	7441	27	SIRS	SIRS	NNP
cord-015021-pol2qm74	7441	28	)	)	-RRB-
cord-015021-pol2qm74	7441	29	,	,	,
cord-015021-pol2qm74	7441	30	and	and	CC
cord-015021-pol2qm74	7441	31	acute	acute	JJ
cord-015021-pol2qm74	7441	32	respiratory	respiratory	JJ
cord-015021-pol2qm74	7441	33	failure	failure	NN
cord-015021-pol2qm74	7441	34	were	be	VBD
cord-015021-pol2qm74	7441	35	applied	apply	VBN
cord-015021-pol2qm74	7441	36	daily	daily	RB
cord-015021-pol2qm74	7441	37	.	.	.
cord-015021-pol2qm74	7442	1	A	a	DT
cord-015021-pol2qm74	7442	2	response	response	NN
cord-015021-pol2qm74	7442	3	to	to	IN
cord-015021-pol2qm74	7442	4	filgrastinl	filgrastinl	NNP
cord-015021-pol2qm74	7442	5	th_erapy	th_erapy	NNP
cord-015021-pol2qm74	7442	6	was	be	VBD
cord-015021-pol2qm74	7442	7	defined	define	VBN
cord-015021-pol2qm74	7442	8	as	as	IN
cord-015021-pol2qm74	7442	9	an	an	DT
cord-015021-pol2qm74	7442	10	improvement	improvement	NN
cord-015021-pol2qm74	7442	11	in	in	IN
cord-015021-pol2qm74	7442	12	disease	disease	NN
cord-015021-pol2qm74	7442	13	severity	severity	NN
cord-015021-pol2qm74	7442	14	quantified	quantify	VBN
cord-015021-pol2qm74	7442	15	by	by	IN
cord-015021-pol2qm74	7442	16	a	a	DT
cord-015021-pol2qm74	7442	17	decrease	decrease	NN
cord-015021-pol2qm74	7442	18	of	of	IN
cord-015021-pol2qm74	7442	19	>	>	XX
cord-015021-pol2qm74	7442	20	4	4	CD
cord-015021-pol2qm74	7442	21	APACHE	APACHE	NNP
cord-015021-pol2qm74	7442	22	1I	1i	CD
cord-015021-pol2qm74	7442	23	score	score	NN
cord-015021-pol2qm74	7442	24	points	point	NNS
cord-015021-pol2qm74	7442	25	on	on	IN
cord-015021-pol2qm74	7442	26	day	day	NN
cord-015021-pol2qm74	7442	27	4	4	CD
cord-015021-pol2qm74	7442	28	after	after	IN
cord-015021-pol2qm74	7442	29	onset	onset	NN
cord-015021-pol2qm74	7442	30	of	of	IN
cord-015021-pol2qm74	7442	31	treatment	treatment	NN
cord-015021-pol2qm74	7442	32	.	.	.
cord-015021-pol2qm74	7443	1	Results	result	NNS
cord-015021-pol2qm74	7443	2	:	:	:
cord-015021-pol2qm74	7444	1	None	none	NN
cord-015021-pol2qm74	7444	2	of	of	IN
cord-015021-pol2qm74	7444	3	the	the	DT
cord-015021-pol2qm74	7444	4	10	10	CD
cord-015021-pol2qm74	7444	5	patients	patient	NNS
cord-015021-pol2qm74	7444	6	developed	develop	VBD
cord-015021-pol2qm74	7444	7	a	a	DT
cord-015021-pol2qm74	7444	8	sepsis	sepsis	NN
cord-015021-pol2qm74	7444	9	or	or	CC
cord-015021-pol2qm74	7444	10	MOF	MOF	NNP
cord-015021-pol2qm74	7444	11	later	later	RB
cord-015021-pol2qm74	7444	12	on	on	RB
cord-015021-pol2qm74	7444	13	and	and	CC
cord-015021-pol2qm74	7444	14	no	no	DT
cord-015021-pol2qm74	7444	15	patient	patient	NN
cord-015021-pol2qm74	7444	16	died	die	VBD
cord-015021-pol2qm74	7444	17	during	during	IN
cord-015021-pol2qm74	7444	18	hospitalization	hospitalization	NN
cord-015021-pol2qm74	7444	19	.	.	.
cord-015021-pol2qm74	7445	1	Specific	specific	JJ
cord-015021-pol2qm74	7445	2	postoperative	postoperative	JJ
cord-015021-pol2qm74	7445	3	complications	complication	NNS
cord-015021-pol2qm74	7445	4	occured	occur	VBD
cord-015021-pol2qm74	7445	5	in	in	IN
cord-015021-pol2qm74	7445	6	one	one	CD
cord-015021-pol2qm74	7445	7	patient	patient	NN
cord-015021-pol2qm74	7445	8	~Jth	~Jth	VBZ
cord-015021-pol2qm74	7445	9	a	a	DT
cord-015021-pol2qm74	7445	10	leekage	leekage	NN
cord-015021-pol2qm74	7445	11	of	of	IN
cord-015021-pol2qm74	7445	12	the	the	DT
cord-015021-pol2qm74	7445	13	oesophagou	oesophagou	NN
cord-015021-pol2qm74	7445	14	-	-	HYPH
cord-015021-pol2qm74	7445	15	gastric	gastric	JJ
cord-015021-pol2qm74	7445	16	anastomosis	anastomosis	NN
cord-015021-pol2qm74	7445	17	after	after	IN
cord-015021-pol2qm74	7445	18	oesophageus	oesophageus	NNP
cord-015021-pol2qm74	7445	19	resection	resection	NN
cord-015021-pol2qm74	7445	20	.	.	.
cord-015021-pol2qm74	7446	1	At	at	IN
cord-015021-pol2qm74	7446	2	study	study	NN
cord-015021-pol2qm74	7446	3	entry	entry	NN
cord-015021-pol2qm74	7446	4	the	the	DT
cord-015021-pol2qm74	7446	5	leucocytes	leucocyte	NNS
cord-015021-pol2qm74	7446	6	amounted	amount	VBD
cord-015021-pol2qm74	7446	7	to	to	IN
cord-015021-pol2qm74	7446	8	10.110	10.110	CD
cord-015021-pol2qm74	7446	9	+	+	CD
cord-015021-pol2qm74	7446	10	2.000/~tl	2.000/~tl	CD
cord-015021-pol2qm74	7447	1	(	(	-LRB-
cord-015021-pol2qm74	7447	2	mean	mean	VB
cord-015021-pol2qm74	7447	3	+	+	CC
cord-015021-pol2qm74	7447	4	SEM	SEM	NNP
cord-015021-pol2qm74	7447	5	)	)	-RRB-
cord-015021-pol2qm74	7447	6	and	and	CC
cord-015021-pol2qm74	7447	7	reached	reach	VBD
cord-015021-pol2qm74	7447	8	a	a	DT
cord-015021-pol2qm74	7447	9	level	level	NN
cord-015021-pol2qm74	7447	10	of	of	IN
cord-015021-pol2qm74	7447	11	29.280	29.280	CD
cord-015021-pol2qm74	7448	1	+	+	CC
cord-015021-pol2qm74	7449	1	_	_	NNP
cord-015021-pol2qm74	7449	2	5.810	5.810	CD
cord-015021-pol2qm74	7449	3	/	/	SYM
cord-015021-pol2qm74	7449	4	tal	tal	NNP
cord-015021-pol2qm74	7449	5	at	at	IN
cord-015021-pol2qm74	7449	6	day	day	NN
cord-015021-pol2qm74	7449	7	6	6	CD
cord-015021-pol2qm74	7449	8	after	after	IN
cord-015021-pol2qm74	7449	9	onset	onset	NN
cord-015021-pol2qm74	7449	10	offilgrastim	offilgrastim	NNP
cord-015021-pol2qm74	7449	11	therapy	therapy	NN
cord-015021-pol2qm74	7449	12	.	.	.
cord-015021-pol2qm74	7450	1	The	the	DT
cord-015021-pol2qm74	7450	2	APACHE	APACHE	NNP
cord-015021-pol2qm74	7450	3	II	II	NNP
cord-015021-pol2qm74	7450	4	score	score	NN
cord-015021-pol2qm74	7450	5	initally	initally	RB
cord-015021-pol2qm74	7450	6	was	be	VBD
cord-015021-pol2qm74	7450	7	14	14	CD
cord-015021-pol2qm74	7450	8	+	+	SYM
cord-015021-pol2qm74	7450	9	1.57	1.57	CD
cord-015021-pol2qm74	7451	1	(	(	-LRB-
cord-015021-pol2qm74	7451	2	mean	mean	VB
cord-015021-pol2qm74	7451	3	+	+	CC
cord-015021-pol2qm74	7451	4	SEM	SEM	NNP
cord-015021-pol2qm74	7451	5	)	)	-RRB-
cord-015021-pol2qm74	7451	6	and	and	CC
cord-015021-pol2qm74	7451	7	as	as	IN
cord-015021-pol2qm74	7451	8	an	an	DT
cord-015021-pol2qm74	7451	9	indicator	indicator	NN
cord-015021-pol2qm74	7451	10	of	of	IN
cord-015021-pol2qm74	7451	11	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7451	12	response	response	NN
cord-015021-pol2qm74	7451	13	a	a	DT
cord-015021-pol2qm74	7451	14	decrease	decrease	NN
cord-015021-pol2qm74	7451	15	of	of	IN
cord-015021-pol2qm74	7451	16	5	5	CD
cord-015021-pol2qm74	7451	17	points	point	NNS
cord-015021-pol2qm74	7451	18	~dthin	~dthin	NFP
cord-015021-pol2qm74	7452	1	4	4	CD
cord-015021-pol2qm74	7452	2	days	day	NNS
cord-015021-pol2qm74	7452	3	oceured	oceure	VBN
cord-015021-pol2qm74	7452	4	in	in	IN
cord-015021-pol2qm74	7452	5	7	7	CD
cord-015021-pol2qm74	7452	6	out	out	RB
cord-015021-pol2qm74	7452	7	ot	ot	NN
cord-015021-pol2qm74	7452	8	10	10	CD
cord-015021-pol2qm74	7452	9	patients	patient	NNS
cord-015021-pol2qm74	7452	10	.	.	.
cord-015021-pol2qm74	7453	1	Filgrastim	Filgrastim	NNP
cord-015021-pol2qm74	7453	2	was	be	VBD
cord-015021-pol2qm74	7453	3	well	well	RB
cord-015021-pol2qm74	7453	4	tolerated	tolerate	VBN
cord-015021-pol2qm74	7453	5	,	,	,
cord-015021-pol2qm74	7453	6	side	side	NN
cord-015021-pol2qm74	7453	7	effects	effect	NNS
cord-015021-pol2qm74	7453	8	were	be	VBD
cord-015021-pol2qm74	7453	9	not	not	RB
cord-015021-pol2qm74	7453	10	noted	note	VBN
cord-015021-pol2qm74	7453	11	.	.	.
cord-015021-pol2qm74	7454	1	Growth	growth	NN
cord-015021-pol2qm74	7454	2	of	of	IN
cord-015021-pol2qm74	7454	3	solid	solid	JJ
cord-015021-pol2qm74	7454	4	tumors	tumor	NNS
cord-015021-pol2qm74	7454	5	might	may	MD
cord-015021-pol2qm74	7454	6	be	be	VB
cord-015021-pol2qm74	7454	7	modulated	modulate	VBN
cord-015021-pol2qm74	7454	8	by	by	IN
cord-015021-pol2qm74	7454	9	the	the	DT
cord-015021-pol2qm74	7454	10	activity	activity	NN
cord-015021-pol2qm74	7454	11	of	of	IN
cord-015021-pol2qm74	7454	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7454	13	and/or	and/or	CC
cord-015021-pol2qm74	7454	14	immune	immune	JJ
cord-015021-pol2qm74	7454	15	effector	effector	NN
cord-015021-pol2qm74	7454	16	cells	cell	NNS
cord-015021-pol2qm74	7454	17	of	of	IN
cord-015021-pol2qm74	7454	18	undefined	undefined	JJ
cord-015021-pol2qm74	7454	19	specificity	specificity	NN
cord-015021-pol2qm74	7454	20	.	.	.
cord-015021-pol2qm74	7455	1	In	in	IN
cord-015021-pol2qm74	7455	2	this	this	DT
cord-015021-pol2qm74	7455	3	study	study	NN
cord-015021-pol2qm74	7455	4	patients	patient	NNS
cord-015021-pol2qm74	7455	5	undergoing	undergo	VBG
cord-015021-pol2qm74	7455	6	surgical	surgical	JJ
cord-015021-pol2qm74	7455	7	treatment	treatment	NN
cord-015021-pol2qm74	7455	8	for	for	IN
cord-015021-pol2qm74	7455	9	gastric	gastric	JJ
cord-015021-pol2qm74	7455	10	(	(	-LRB-
cord-015021-pol2qm74	7456	1	n=	n=	NNP
cord-015021-pol2qm74	7456	2	41	41	CD
cord-015021-pol2qm74	7456	3	)	)	-RRB-
cord-015021-pol2qm74	7456	4	or	or	CC
cord-015021-pol2qm74	7456	5	colorectal	colorectal	JJ
cord-015021-pol2qm74	7457	1	(	(	-LRB-
cord-015021-pol2qm74	7457	2	n=	n=	NNP
cord-015021-pol2qm74	7457	3	47	47	CD
cord-015021-pol2qm74	7457	4	)	)	-RRB-
cord-015021-pol2qm74	7457	5	cancers	cancer	NNS
cord-015021-pol2qm74	7457	6	were	be	VBD
cord-015021-pol2qm74	7457	7	evaluated	evaluate	VBN
cord-015021-pol2qm74	7457	8	for	for	IN
cord-015021-pol2qm74	7457	9	endogenous	endogenous	JJ
cord-015021-pol2qm74	7457	10	serum	serum	NN
cord-015021-pol2qm74	7457	11	levels	level	NNS
cord-015021-pol2qm74	7457	12	of	of	IN
cord-015021-pol2qm74	7457	13	granulocyte	granulocyte	NN
cord-015021-pol2qm74	7457	14	colony	colony	NN
cord-015021-pol2qm74	7457	15	-	-	HYPH
cord-015021-pol2qm74	7457	16	stimulatingfactor	stimulatingfactor	NNP
cord-015021-pol2qm74	7457	17	(	(	-LRB-
cord-015021-pol2qm74	7457	18	G	G	NNP
cord-015021-pol2qm74	7457	19	-	-	HYPH
cord-015021-pol2qm74	7457	20	CSF	CSF	NNP
cord-015021-pol2qm74	7457	21	)	)	-RRB-
cord-015021-pol2qm74	7457	22	during	during	IN
cord-015021-pol2qm74	7457	23	a	a	DT
cord-015021-pol2qm74	7457	24	pre	pre	NN
cord-015021-pol2qm74	7457	25	-	-	JJ
cord-015021-pol2qm74	7457	26	and	and	CC
cord-015021-pol2qm74	7457	27	postoperative	postoperative	JJ
cord-015021-pol2qm74	7457	28	time	time	NN
cord-015021-pol2qm74	7457	29	period	period	NN
cord-015021-pol2qm74	7457	30	.	.	.
cord-015021-pol2qm74	7458	1	From	from	IN
cord-015021-pol2qm74	7458	2	the	the	DT
cord-015021-pol2qm74	7458	3	same	same	JJ
cord-015021-pol2qm74	7458	4	blood	blood	NN
cord-015021-pol2qm74	7458	5	specimens	specimen	NNS
cord-015021-pol2qm74	7458	6	mononuelcar	mononuelcar	NN
cord-015021-pol2qm74	7458	7	cells	cell	NNS
cord-015021-pol2qm74	7458	8	(	(	-LRB-
cord-015021-pol2qm74	7458	9	MNC	MNC	NNP
cord-015021-pol2qm74	7458	10	)	)	-RRB-
cord-015021-pol2qm74	7458	11	were	be	VBD
cord-015021-pol2qm74	7458	12	prepared	prepare	VBN
cord-015021-pol2qm74	7458	13	.	.	.
cord-015021-pol2qm74	7459	1	The	the	DT
cord-015021-pol2qm74	7459	2	release	release	NN
cord-015021-pol2qm74	7459	3	of	of	IN
cord-015021-pol2qm74	7459	4	IFN-%	IFN-%	NNP
cord-015021-pol2qm74	7459	5	,	,	,
cord-015021-pol2qm74	7459	6	and	and	CC
cord-015021-pol2qm74	7459	7	IL-2	IL-2	NNP
cord-015021-pol2qm74	7459	8	,	,	,
cord-015021-pol2qm74	7459	9	which	which	WDT
cord-015021-pol2qm74	7459	10	are	be	VBP
cord-015021-pol2qm74	7459	11	secreted	secrete	VBN
cord-015021-pol2qm74	7459	12	by	by	IN
cord-015021-pol2qm74	7459	13	Thl	Thl	NNP
cord-015021-pol2qm74	7459	14	cells	cell	NNS
cord-015021-pol2qm74	7459	15	,	,	,
cord-015021-pol2qm74	7459	16	were	be	VBD
cord-015021-pol2qm74	7459	17	stimulated	stimulate	VBN
cord-015021-pol2qm74	7459	18	in	in	IN
cord-015021-pol2qm74	7459	19	vitro	vitro	FW
cord-015021-pol2qm74	7459	20	by	by	IN
cord-015021-pol2qm74	7459	21	PHA	PHA	NNP
cord-015021-pol2qm74	7459	22	during	during	IN
cord-015021-pol2qm74	7459	23	a	a	DT
cord-015021-pol2qm74	7459	24	cell	cell	NN
cord-015021-pol2qm74	7459	25	culture	culture	NN
cord-015021-pol2qm74	7459	26	period	period	NN
cord-015021-pol2qm74	7459	27	up	up	IN
cord-015021-pol2qm74	7459	28	to	to	TO
cord-015021-pol2qm74	7459	29	48	48	CD
cord-015021-pol2qm74	7459	30	hours	hour	NNS
cord-015021-pol2qm74	7459	31	.	.	.
cord-015021-pol2qm74	7460	1	The	the	DT
cord-015021-pol2qm74	7460	2	patients	patient	NNS
cord-015021-pol2qm74	7460	3	were	be	VBD
cord-015021-pol2qm74	7460	4	further	further	RB
cord-015021-pol2qm74	7460	5	classified	classify	VBN
cord-015021-pol2qm74	7460	6	for	for	IN
cord-015021-pol2qm74	7460	7	their	-PRON-	PRP$
cord-015021-pol2qm74	7460	8	immunreactivity	immunreactivity	NN
cord-015021-pol2qm74	7460	9	by	by	IN
cord-015021-pol2qm74	7460	10	responses	response	NNS
cord-015021-pol2qm74	7460	11	in	in	IN
cord-015021-pol2qm74	7460	12	DTH	DTH	NNP
cord-015021-pol2qm74	7460	13	skin	skin	NN
cord-015021-pol2qm74	7460	14	testing	testing	NN
cord-015021-pol2qm74	7460	15	to	to	IN
cord-015021-pol2qm74	7460	16	seven	seven	CD
cord-015021-pol2qm74	7460	17	different	different	JJ
cord-015021-pol2qm74	7460	18	antigens	antigen	NNS
cord-015021-pol2qm74	7460	19	(	(	-LRB-
cord-015021-pol2qm74	7460	20	e.g.	e.g.	RB
cord-015021-pol2qm74	7460	21	tetanus	tetanus	JJ
cord-015021-pol2qm74	7460	22	toxoid	toxoid	NN
cord-015021-pol2qm74	7460	23	,	,	,
cord-015021-pol2qm74	7460	24	PPD	PPD	NNP
cord-015021-pol2qm74	7460	25	,	,	,
cord-015021-pol2qm74	7460	26	diphtheria	diphtheria	NN
cord-015021-pol2qm74	7460	27	toxin	toxin	NN
cord-015021-pol2qm74	7460	28	,	,	,
cord-015021-pol2qm74	7460	29	trichophyton	trichophyton	NN
cord-015021-pol2qm74	7460	30	,	,	,
cord-015021-pol2qm74	7460	31	streptococcus	streptococcus	NN
cord-015021-pol2qm74	7460	32	,	,	,
cord-015021-pol2qm74	7460	33	candida	candida	NN
cord-015021-pol2qm74	7460	34	and	and	CC
cord-015021-pol2qm74	7460	35	proteus	proteus	NNP
cord-015021-pol2qm74	7460	36	antigens	antigen	NNS
cord-015021-pol2qm74	7460	37	)	)	-RRB-
cord-015021-pol2qm74	7460	38	.	.	.
cord-015021-pol2qm74	7461	1	DTH	DTH	NNP
cord-015021-pol2qm74	7461	2	testing	testing	NN
cord-015021-pol2qm74	7461	3	has	have	VBZ
cord-015021-pol2qm74	7461	4	been	be	VBN
cord-015021-pol2qm74	7461	5	repeated	repeat	VBN
cord-015021-pol2qm74	7461	6	in	in	IN
cord-015021-pol2qm74	7461	7	each	each	DT
cord-015021-pol2qm74	7461	8	patient	patient	JJ
cord-015021-pol2qm74	7461	9	Two	two	CD
cord-015021-pol2qm74	7461	10	remarkable	remarkable	JJ
cord-015021-pol2qm74	7461	11	results	result	NNS
cord-015021-pol2qm74	7461	12	were	be	VBD
cord-015021-pol2qm74	7461	13	obtained	obtain	VBN
cord-015021-pol2qm74	7461	14	.	.	.
cord-015021-pol2qm74	7462	1	The	the	DT
cord-015021-pol2qm74	7462	2	serum	serum	NN
cord-015021-pol2qm74	7462	3	levels	level	NNS
cord-015021-pol2qm74	7462	4	of	of	IN
cord-015021-pol2qm74	7462	5	endogenous	endogenous	JJ
cord-015021-pol2qm74	7462	6	G	G	NNP
cord-015021-pol2qm74	7462	7	-	-	HYPH
cord-015021-pol2qm74	7462	8	CSE	CSE	NNP
cord-015021-pol2qm74	7462	9	showed	show	VBD
cord-015021-pol2qm74	7462	10	a	a	DT
cord-015021-pol2qm74	7462	11	biphasic	biphasic	JJ
cord-015021-pol2qm74	7462	12	increase	increase	NN
cord-015021-pol2qm74	7462	13	with	with	IN
cord-015021-pol2qm74	7462	14	maximum	maximum	JJ
cord-015021-pol2qm74	7462	15	values	value	NNS
cord-015021-pol2qm74	7462	16	of	of	IN
cord-015021-pol2qm74	7462	17	900	900	CD
cord-015021-pol2qm74	7462	18	pg	pg	NN
cord-015021-pol2qm74	7462	19	/	/	SYM
cord-015021-pol2qm74	7462	20	ml	ml	NN
cord-015021-pol2qm74	7462	21	(	(	-LRB-
cord-015021-pol2qm74	7462	22	preoperative	preoperative	JJ
cord-015021-pol2qm74	7462	23	<	<	XX
cord-015021-pol2qm74	7462	24	70	70	CD
cord-015021-pol2qm74	7462	25	pg	pg	NN
cord-015021-pol2qm74	7462	26	/	/	SYM
cord-015021-pol2qm74	7462	27	ml	ml	NNP
cord-015021-pol2qm74	7462	28	)	)	-RRB-
cord-015021-pol2qm74	7462	29	on	on	IN
cord-015021-pol2qm74	7462	30	day	day	NN
cord-015021-pol2qm74	7462	31	1	1	CD
cord-015021-pol2qm74	7462	32	and	and	CC
cord-015021-pol2qm74	7462	33	day	day	NN
cord-015021-pol2qm74	7462	34	3	3	CD
cord-015021-pol2qm74	7462	35	to	to	IN
cord-015021-pol2qm74	7462	36	5	5	CD
cord-015021-pol2qm74	7462	37	after	after	IN
cord-015021-pol2qm74	7462	38	surgical	surgical	JJ
cord-015021-pol2qm74	7462	39	treatment	treatment	NN
cord-015021-pol2qm74	7462	40	.	.	.
cord-015021-pol2qm74	7463	1	Similar	similar	JJ
cord-015021-pol2qm74	7463	2	patterns	pattern	NNS
cord-015021-pol2qm74	7463	3	of	of	IN
cord-015021-pol2qm74	7463	4	G	G	NNP
cord-015021-pol2qm74	7463	5	-	-	HYPH
cord-015021-pol2qm74	7463	6	CSF	csf	NN
cord-015021-pol2qm74	7463	7	production	production	NN
cord-015021-pol2qm74	7463	8	were	be	VBD
cord-015021-pol2qm74	7463	9	found	find	VBN
cord-015021-pol2qm74	7463	10	in	in	IN
cord-015021-pol2qm74	7463	11	both	both	DT
cord-015021-pol2qm74	7463	12	groups	group	NNS
cord-015021-pol2qm74	7463	13	of	of	IN
cord-015021-pol2qm74	7463	14	patients	patient	NNS
cord-015021-pol2qm74	7463	15	with	with	IN
cord-015021-pol2qm74	7463	16	gastric	gastric	JJ
cord-015021-pol2qm74	7463	17	or	or	CC
cord-015021-pol2qm74	7463	18	colorectal	colorectal	JJ
cord-015021-pol2qm74	7463	19	cancers	cancer	NNS
cord-015021-pol2qm74	7463	20	.	.	.
cord-015021-pol2qm74	7464	1	High	high	JJ
cord-015021-pol2qm74	7464	2	serum	serum	NN
cord-015021-pol2qm74	7464	3	levels	level	NNS
cord-015021-pol2qm74	7464	4	of	of	IN
cord-015021-pol2qm74	7464	5	G	G	NNP
cord-015021-pol2qm74	7464	6	-	-	HYPH
cord-015021-pol2qm74	7464	7	CSF	CSF	NNP
cord-015021-pol2qm74	7464	8	were	be	VBD
cord-015021-pol2qm74	7464	9	significantly	significantly	RB
cord-015021-pol2qm74	7464	10	(	(	-LRB-
cord-015021-pol2qm74	7464	11	p	p	NN
cord-015021-pol2qm74	7464	12	<	<	XX
cord-015021-pol2qm74	7464	13	0,01	0,01	NN
cord-015021-pol2qm74	7464	14	)	)	-RRB-
cord-015021-pol2qm74	7464	15	correlated	correlate	VBN
cord-015021-pol2qm74	7464	16	with	with	IN
cord-015021-pol2qm74	7464	17	infectious	infectious	JJ
cord-015021-pol2qm74	7464	18	complications	complication	NNS
cord-015021-pol2qm74	7464	19	in	in	IN
cord-015021-pol2qm74	7464	20	patients	patient	NNS
cord-015021-pol2qm74	7464	21	whh	whh	VBG
cord-015021-pol2qm74	7464	22	gastric	gastric	JJ
cord-015021-pol2qm74	7464	23	cancer	cancer	NN
cord-015021-pol2qm74	7464	24	(	(	-LRB-
cord-015021-pol2qm74	7464	25	n=	n=	NNP
cord-015021-pol2qm74	7464	26	17/22	17/22	CD
cord-015021-pol2qm74	7464	27	)	)	-RRB-
cord-015021-pol2qm74	7464	28	.	.	.
cord-015021-pol2qm74	7465	1	Secondly	secondly	RB
cord-015021-pol2qm74	7465	2	patients	patient	NNS
cord-015021-pol2qm74	7465	3	could	could	MD
cord-015021-pol2qm74	7465	4	be	be	VB
cord-015021-pol2qm74	7465	5	arranged	arrange	VBN
cord-015021-pol2qm74	7465	6	into	into	IN
cord-015021-pol2qm74	7465	7	two	two	CD
cord-015021-pol2qm74	7465	8	groups	group	NNS
cord-015021-pol2qm74	7465	9	according	accord	VBG
cord-015021-pol2qm74	7465	10	to	to	IN
cord-015021-pol2qm74	7465	11	an	an	DT
cord-015021-pol2qm74	7465	12	anergic	anergic	NN
cord-015021-pol2qm74	7466	1	(	(	-LRB-
cord-015021-pol2qm74	7466	2	n=	n=	NNP
cord-015021-pol2qm74	7466	3	25	25	CD
cord-015021-pol2qm74	7466	4	)	)	-RRB-
cord-015021-pol2qm74	7466	5	or	or	CC
cord-015021-pol2qm74	7467	1	normergi¢	normergi¢	NNP
cord-015021-pol2qm74	7467	2	(	(	-LRB-
cord-015021-pol2qm74	7467	3	n	n	NN
cord-015021-pol2qm74	7467	4	=	=	SYM
cord-015021-pol2qm74	7467	5	63	63	CD
cord-015021-pol2qm74	7467	6	)	)	-RRB-
cord-015021-pol2qm74	7467	7	responsiveness	responsiveness	NN
cord-015021-pol2qm74	7467	8	in	in	IN
cord-015021-pol2qm74	7467	9	DTH	DTH	NNP
cord-015021-pol2qm74	7467	10	testing	testing	NN
cord-015021-pol2qm74	7467	11	.	.	.
cord-015021-pol2qm74	7468	1	The	the	DT
cord-015021-pol2qm74	7468	2	frequency	frequency	NN
cord-015021-pol2qm74	7468	3	of	of	IN
cord-015021-pol2qm74	7468	4	anergi¢	anergi¢	NN
cord-015021-pol2qm74	7468	5	responsiveness	responsiveness	NN
cord-015021-pol2qm74	7468	6	was	be	VBD
cord-015021-pol2qm74	7468	7	similar	similar	JJ
cord-015021-pol2qm74	7468	8	in	in	IN
cord-015021-pol2qm74	7468	9	both	both	DT
cord-015021-pol2qm74	7468	10	patients	patient	NNS
cord-015021-pol2qm74	7468	11	with	with	IN
cord-015021-pol2qm74	7468	12	gastric	gastric	JJ
cord-015021-pol2qm74	7468	13	(	(	-LRB-
cord-015021-pol2qm74	7468	14	n=	n=	NNP
cord-015021-pol2qm74	7468	15	11/41	11/41	CD
cord-015021-pol2qm74	7468	16	)	)	-RRB-
cord-015021-pol2qm74	7468	17	or	or	CC
cord-015021-pol2qm74	7468	18	colorectal	colorectal	JJ
cord-015021-pol2qm74	7469	1	(	(	-LRB-
cord-015021-pol2qm74	7469	2	n=	n=	NNP
cord-015021-pol2qm74	7469	3	14/47	14/47	CD
cord-015021-pol2qm74	7469	4	)	)	-RRB-
cord-015021-pol2qm74	7469	5	cancers	cancer	NNS
cord-015021-pol2qm74	7469	6	.	.	.
cord-015021-pol2qm74	7470	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	7470	2	we	-PRON-	PRP
cord-015021-pol2qm74	7470	3	found	find	VBD
cord-015021-pol2qm74	7470	4	a	a	DT
cord-015021-pol2qm74	7470	5	significant	significant	JJ
cord-015021-pol2qm74	7470	6	correlation	correlation	NN
cord-015021-pol2qm74	7470	7	(	(	-LRB-
cord-015021-pol2qm74	7470	8	p	p	NN
cord-015021-pol2qm74	7470	9	<	<	XX
cord-015021-pol2qm74	7470	10	0,01	0,01	XX
cord-015021-pol2qm74	7470	11	)	)	-RRB-
cord-015021-pol2qm74	7470	12	between	between	IN
cord-015021-pol2qm74	7470	13	low	low	JJ
cord-015021-pol2qm74	7470	14	serum	serum	NN
cord-015021-pol2qm74	7470	15	levels	level	NNS
cord-015021-pol2qm74	7470	16	of	of	IN
cord-015021-pol2qm74	7470	17	G	G	NNP
cord-015021-pol2qm74	7470	18	-	-	HYPH
cord-015021-pol2qm74	7470	19	CSF	CSF	NNP
cord-015021-pol2qm74	7470	20	and	and	CC
cord-015021-pol2qm74	7470	21	anergy	anergy	NNP
cord-015021-pol2qm74	7470	22	during	during	IN
cord-015021-pol2qm74	7470	23	the	the	DT
cord-015021-pol2qm74	7470	24	postoperative	postoperative	JJ
cord-015021-pol2qm74	7470	25	period	period	NN
cord-015021-pol2qm74	7470	26	in	in	IN
cord-015021-pol2qm74	7470	27	both	both	DT
cord-015021-pol2qm74	7470	28	groups	group	NNS
cord-015021-pol2qm74	7470	29	.	.	.
cord-015021-pol2qm74	7471	1	Stimulation	stimulation	NN
cord-015021-pol2qm74	7471	2	of	of	IN
cord-015021-pol2qm74	7471	3	MNCs	mnc	NNS
cord-015021-pol2qm74	7471	4	from	from	IN
cord-015021-pol2qm74	7471	5	anergic	anergic	NN
cord-015021-pol2qm74	7471	6	patients	patient	NNS
cord-015021-pol2qm74	7471	7	(	(	-LRB-
cord-015021-pol2qm74	7471	8	n=	n=	NNP
cord-015021-pol2qm74	7471	9	30	30	CD
cord-015021-pol2qm74	7471	10	)	)	-RRB-
cord-015021-pol2qm74	7471	11	within	within	IN
cord-015021-pol2qm74	7471	12	the	the	DT
cord-015021-pol2qm74	7471	13	pre	pre	NN
cord-015021-pol2qm74	7471	14	-	-	JJ
cord-015021-pol2qm74	7471	15	and	and	CC
cord-015021-pol2qm74	7471	16	postoperative	postoperative	JJ
cord-015021-pol2qm74	7471	17	period	period	NN
cord-015021-pol2qm74	7471	18	resulted	result	VBD
cord-015021-pol2qm74	7471	19	in	in	IN
cord-015021-pol2qm74	7471	20	reduced	reduce	VBN
cord-015021-pol2qm74	7471	21	mean	mean	JJ
cord-015021-pol2qm74	7471	22	values	value	NNS
cord-015021-pol2qm74	7471	23	(	(	-LRB-
cord-015021-pol2qm74	7471	24	about	about	RB
cord-015021-pol2qm74	7471	25	50	50	CD
cord-015021-pol2qm74	7471	26	%	%	NN
cord-015021-pol2qm74	7471	27	)	)	-RRB-
cord-015021-pol2qm74	7471	28	for	for	IN
cord-015021-pol2qm74	7471	29	IFN	IFN	NNP
cord-015021-pol2qm74	7471	30	-	-	HYPH
cord-015021-pol2qm74	7471	31	ff	ff	NNP
cord-015021-pol2qm74	7471	32	release	release	NN
cord-015021-pol2qm74	7471	33	(	(	-LRB-
cord-015021-pol2qm74	7471	34	preoperative	preoperative	JJ
cord-015021-pol2qm74	7471	35	means	mean	NNS
cord-015021-pol2qm74	7471	36	llO0	llO0	NNP
cord-015021-pol2qm74	7471	37	pg	pg	NNP
cord-015021-pol2qm74	7471	38	/	/	SYM
cord-015021-pol2qm74	7471	39	nfl	nfl	NNP
cord-015021-pol2qm74	7471	40	)	)	-RRB-
cord-015021-pol2qm74	7471	41	,	,	,
cord-015021-pol2qm74	7471	42	if	if	IN
cord-015021-pol2qm74	7471	43	compared	compare	VBN
cord-015021-pol2qm74	7471	44	to	to	IN
cord-015021-pol2qm74	7471	45	patients	patient	NNS
cord-015021-pol2qm74	7471	46	with	with	IN
cord-015021-pol2qm74	7471	47	normergic	normergic	NNP
cord-015021-pol2qm74	7471	48	DTH	DTH	NNP
cord-015021-pol2qm74	7471	49	(	(	-LRB-
cord-015021-pol2qm74	7471	50	n=	n=	NNP
cord-015021-pol2qm74	7471	51	63	63	CD
cord-015021-pol2qm74	7471	52	,	,	,
cord-015021-pol2qm74	7471	53	preoperative	preoperative	JJ
cord-015021-pol2qm74	7471	54	means	mean	NNS
cord-015021-pol2qm74	7471	55	1960	1960	CD
cord-015021-pol2qm74	7471	56	pg	pg	NNP
cord-015021-pol2qm74	7471	57	/	/	SYM
cord-015021-pol2qm74	7471	58	ml	ml	NNP
cord-015021-pol2qm74	7471	59	)	)	-RRB-
cord-015021-pol2qm74	7471	60	.	.	.
cord-015021-pol2qm74	7472	1	Similar	similar	JJ
cord-015021-pol2qm74	7472	2	,	,	,
cord-015021-pol2qm74	7472	3	but	but	CC
cord-015021-pol2qm74	7472	4	less	less	RBR
cord-015021-pol2qm74	7472	5	significant	significant	JJ
cord-015021-pol2qm74	7472	6	results	result	NNS
cord-015021-pol2qm74	7472	7	were	be	VBD
cord-015021-pol2qm74	7472	8	obtained	obtain	VBN
cord-015021-pol2qm74	7472	9	for	for	IN
cord-015021-pol2qm74	7472	10	IL-2	il-2	NN
cord-015021-pol2qm74	7472	11	secretion	secretion	NN
cord-015021-pol2qm74	7472	12	.	.	.
cord-015021-pol2qm74	7473	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	7473	2	results	result	NNS
cord-015021-pol2qm74	7473	3	confirm	confirm	VBP
cord-015021-pol2qm74	7473	4	a	a	DT
cord-015021-pol2qm74	7473	5	correlation	correlation	NN
cord-015021-pol2qm74	7473	6	between	between	IN
cord-015021-pol2qm74	7473	7	infectious	infectious	JJ
cord-015021-pol2qm74	7473	8	complications	complication	NNS
cord-015021-pol2qm74	7473	9	and	and	CC
cord-015021-pol2qm74	7473	10	G	G	NNP
cord-015021-pol2qm74	7473	11	-	-	HYPH
cord-015021-pol2qm74	7473	12	CSF	CSF	NNP
cord-015021-pol2qm74	7473	13	in	in	IN
cord-015021-pol2qm74	7473	14	the	the	DT
cord-015021-pol2qm74	7473	15	postoperative	postoperative	JJ
cord-015021-pol2qm74	7473	16	period	period	NN
cord-015021-pol2qm74	7473	17	,	,	,
cord-015021-pol2qm74	7473	18	however	however	RB
cord-015021-pol2qm74	7473	19	elevated	elevated	JJ
cord-015021-pol2qm74	7473	20	levels	level	NNS
cord-015021-pol2qm74	7473	21	were	be	VBD
cord-015021-pol2qm74	7473	22	also	also	RB
cord-015021-pol2qm74	7473	23	found	find	VBN
cord-015021-pol2qm74	7473	24	in	in	IN
cord-015021-pol2qm74	7473	25	some	some	DT
cord-015021-pol2qm74	7473	26	patients	patient	NNS
cord-015021-pol2qm74	7473	27	without	without	IN
cord-015021-pol2qm74	7473	28	any	any	DT
cord-015021-pol2qm74	7473	29	signs	sign	NNS
cord-015021-pol2qm74	7473	30	of	of	IN
cord-015021-pol2qm74	7473	31	infections	infection	NNS
cord-015021-pol2qm74	7473	32	.	.	.
cord-015021-pol2qm74	7474	1	More	more	RBR
cord-015021-pol2qm74	7474	2	interestingly	interestingly	RB
cord-015021-pol2qm74	7474	3	there	there	EX
cord-015021-pol2qm74	7474	4	might	may	MD
cord-015021-pol2qm74	7474	5	be	be	VB
cord-015021-pol2qm74	7474	6	an	an	DT
cord-015021-pol2qm74	7474	7	association	association	NN
cord-015021-pol2qm74	7474	8	between	between	IN
cord-015021-pol2qm74	7474	9	cytokine	cytokine	NN
cord-015021-pol2qm74	7474	10	(	(	-LRB-
cord-015021-pol2qm74	7474	11	C	C	NNP
cord-015021-pol2qm74	7474	12	~	~	NFP
cord-015021-pol2qm74	7474	13	CSF	CSF	NNP
cord-015021-pol2qm74	7474	14	,	,	,
cord-015021-pol2qm74	7474	15	IFN-%	IFN-%	NNP
cord-015021-pol2qm74	7474	16	and	and	CC
cord-015021-pol2qm74	7474	17	IL-2	IL-2	NNP
cord-015021-pol2qm74	7474	18	)	)	-RRB-
cord-015021-pol2qm74	7474	19	release	release	VBP
cord-015021-pol2qm74	7474	20	and	and	CC
cord-015021-pol2qm74	7474	21	DTH	DTH	NNP
cord-015021-pol2qm74	7474	22	,	,	,
cord-015021-pol2qm74	7474	23	which	which	WDT
cord-015021-pol2qm74	7474	24	is	be	VBZ
cord-015021-pol2qm74	7474	25	known	know	VBN
cord-015021-pol2qm74	7474	26	to	to	TO
cord-015021-pol2qm74	7474	27	be	be	VB
cord-015021-pol2qm74	7474	28	mediated	mediate	VBN
cord-015021-pol2qm74	7474	29	by	by	IN
cord-015021-pol2qm74	7474	30	activated	activate	VBN
cord-015021-pol2qm74	7474	31	Thl	Thl	NNP
cord-015021-pol2qm74	7474	32	calls	call	VBZ
cord-015021-pol2qm74	7474	33	.	.	.
cord-015021-pol2qm74	7475	1	To	to	TO
cord-015021-pol2qm74	7475	2	recognize	recognize	VB
cord-015021-pol2qm74	7475	3	anergic	anergic	NN
cord-015021-pol2qm74	7475	4	DTH	DTH	NNP
cord-015021-pol2qm74	7475	5	as	as	IN
cord-015021-pol2qm74	7475	6	a	a	DT
cord-015021-pol2qm74	7475	7	possible	possible	JJ
cord-015021-pol2qm74	7475	8	higher	high	JJR
cord-015021-pol2qm74	7475	9	risk	risk	NN
cord-015021-pol2qm74	7475	10	in	in	IN
cord-015021-pol2qm74	7475	11	the	the	DT
cord-015021-pol2qm74	7475	12	postoperative	postoperative	JJ
cord-015021-pol2qm74	7475	13	outcome	outcome	NN
cord-015021-pol2qm74	7475	14	of	of	IN
cord-015021-pol2qm74	7475	15	cancer	cancer	NN
cord-015021-pol2qm74	7475	16	patients	patient	NNS
cord-015021-pol2qm74	7475	17	extended	extend	VBN
cord-015021-pol2qm74	7475	18	periods	period	NNS
cord-015021-pol2qm74	7475	19	of	of	IN
cord-015021-pol2qm74	7475	20	observation	observation	NN
cord-015021-pol2qm74	7475	21	are	be	VBP
cord-015021-pol2qm74	7475	22	needed	need	VBN
cord-015021-pol2qm74	7475	23	.	.	.
cord-015021-pol2qm74	7476	1	Objectives	objective	NNS
cord-015021-pol2qm74	7476	2	of	of	IN
cord-015021-pol2qm74	7476	3	the	the	DT
cord-015021-pol2qm74	7476	4	study	study	NN
cord-015021-pol2qm74	7476	5	Effects	effect	NNS
cord-015021-pol2qm74	7476	6	of	of	IN
cord-015021-pol2qm74	7476	7	recombinant	recombinant	JJ
cord-015021-pol2qm74	7476	8	huraan	huraan	NN
cord-015021-pol2qm74	7476	9	granulocyte	granulocyte	NN
cord-015021-pol2qm74	7476	10	colony	colony	NN
cord-015021-pol2qm74	7476	11	-	-	HYPH
cord-015021-pol2qm74	7476	12	stimulating	stimulate	VBG
cord-015021-pol2qm74	7476	13	factor(rhC	factor(rhc	NN
cord-015021-pol2qm74	7476	14	-	-	HYPH
cord-015021-pol2qm74	7476	15	CSF)a	csf)a	JJ
cord-015021-pol2qm74	7476	16	galnst	galnst	NN
cord-015021-pol2qm74	7476	17	severe	severe	JJ
cord-015021-pol2qm74	7476	18	septic	septic	JJ
cord-015021-pol2qm74	7476	19	infections	infection	NNS
cord-015021-pol2qm74	7476	20	were	be	VBD
cord-015021-pol2qm74	7476	21	investigated	investigate	VBN
cord-015021-pol2qm74	7476	22	by	by	IN
cord-015021-pol2qm74	7476	23	its	-PRON-	PRP$
cord-015021-pol2qm74	7476	24	single	single	JJ
cord-015021-pol2qm74	7476	25	use	use	NN
cord-015021-pol2qm74	7476	26	or	or	CC
cord-015021-pol2qm74	7476	27	by	by	IN
cord-015021-pol2qm74	7476	28	its	-PRON-	PRP$
cord-015021-pol2qm74	7476	29	corn	corn	NN
cord-015021-pol2qm74	7476	30	b{nation	b{nation	NN
cord-015021-pol2qm74	7476	31	with	with	IN
cord-015021-pol2qm74	7476	32	cephera	cephera	NNP
cord-015021-pol2qm74	7476	33	antibiotlcs	antibiotlcs	NNP
cord-015021-pol2qm74	7476	34	.	.	.
cord-015021-pol2qm74	7477	1	We	-PRON-	PRP
cord-015021-pol2qm74	7477	2	examined	examine	VBD
cord-015021-pol2qm74	7477	3	its	-PRON-	PRP$
cord-015021-pol2qm74	7477	4	effects	effect	NNS
cord-015021-pol2qm74	7477	5	on	on	IN
cord-015021-pol2qm74	7477	6	the	the	DT
cord-015021-pol2qm74	7477	7	mortality	mortality	NN
cord-015021-pol2qm74	7477	8	,	,	,
cord-015021-pol2qm74	7477	9	and	and	CC
cord-015021-pol2qm74	7477	10	circulating	circulate	VBG
cord-015021-pol2qm74	7477	11	blood	blood	NN
cord-015021-pol2qm74	7477	12	neutrophyis	neutrophyis	NNP
cord-015021-pol2qm74	7477	13	counts	count	VBZ
cord-015021-pol2qm74	7477	14	and	and	CC
cord-015021-pol2qm74	7477	15	functlons	functlon	NNS
cord-015021-pol2qm74	7477	16	,	,	,
cord-015021-pol2qm74	7477	17	such	such	JJ
cord-015021-pol2qm74	7477	18	as	as	IN
cord-015021-pol2qm74	7477	19	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7477	20	activity	activity	NN
cord-015021-pol2qm74	7477	21	and	and	CC
cord-015021-pol2qm74	7477	22	H	h	NN
cord-015021-pol2qm74	7477	23	2	2	CD
cord-015021-pol2qm74	7477	24	02	02	CD
cord-015021-pol2qm74	7477	25	production	production	NN
cord-015021-pol2qm74	7477	26	using	use	VBG
cord-015021-pol2qm74	7477	27	the	the	DT
cord-015021-pol2qm74	7477	28	rat	rat	NN
cord-015021-pol2qm74	7477	29	severe	severe	JJ
cord-015021-pol2qm74	7477	30	septic	septic	JJ
cord-015021-pol2qm74	7477	31	model	model	NN
cord-015021-pol2qm74	7477	32	.	.	.
cord-015021-pol2qm74	7478	1	Rats	rat	NNS
cord-015021-pol2qm74	7478	2	were	be	VBD
cord-015021-pol2qm74	7478	3	subcutaneously	subcutaneously	RB
cord-015021-pol2qm74	7478	4	administsrd	administsrd	NNP
cord-015021-pol2qm74	7478	5	rhC~	rhC~	NNP
cord-015021-pol2qm74	7479	1	CSF(S0orl0O	CSF(S0orl0O	NNP
cord-015021-pol2qm74	7479	2	~	~	NFP
cord-015021-pol2qm74	7479	3	g	g	NN
cord-015021-pol2qm74	7479	4	/	/	SYM
cord-015021-pol2qm74	7479	5	k~	k~	CD
cord-015021-pol2qm74	7479	6	body	body	NN
cord-015021-pol2qm74	7479	7	wt)after	wt)after	NN
cord-015021-pol2qm74	7479	8	on	on	IN
cord-015021-pol2qm74	7479	9	set	set	NN
cord-015021-pol2qm74	7479	10	of	of	IN
cord-015021-pol2qm74	7479	11	peritonitis	peritonitis	NN
cord-015021-pol2qm74	7479	12	brought	bring	VBN
cord-015021-pol2qm74	7479	13	about	about	RP
cord-015021-pol2qm74	7479	14	by	by	IN
cord-015021-pol2qm74	7479	15	cecal	cecal	NN
cord-015021-pol2qm74	7479	16	]	]	-RRB-
cord-015021-pol2qm74	7479	17	igation	igation	NN
cord-015021-pol2qm74	7479	18	and	and	CC
cord-015021-pol2qm74	7479	19	one	one	CD
cord-015021-pol2qm74	7479	20	puncture	puncture	NN
cord-015021-pol2qm74	7480	1	withe2-gaug	withe2-gaug	IN
cord-015021-pol2qm74	7480	2	e	e	DT
cord-015021-pol2qm74	7480	3	needle	needle	NN
cord-015021-pol2qm74	7480	4	once	once	RB
cord-015021-pol2qm74	7480	5	a	a	DT
cord-015021-pol2qm74	7480	6	day	day	NN
cord-015021-pol2qm74	7480	7	for	for	IN
cord-015021-pol2qm74	7480	8	three	three	CD
cord-015021-pol2qm74	7480	9	days.in	days.in	NNP
cord-015021-pol2qm74	7480	10	addJtlon	addjtlon	NN
cord-015021-pol2qm74	7481	1	,	,	,
cord-015021-pol2qm74	7481	2	cefmetazol	cefmetazol	NNP
cord-015021-pol2qm74	7481	3	Na(CMZ)(50m$/k9	Na(CMZ)(50m$/k9	NNP
cord-015021-pol2qm74	7481	4	bo	bo	NNP
cord-015021-pol2qm74	7481	5	dy	dy	NNP
cord-015021-pol2qm74	7481	6	wt)was	wt)was	NNP
cord-015021-pol2qm74	7481	7	injected	inject	VBD
cord-015021-pol2qm74	7481	8	intrarnustularly	intrarnustularly	RB
cord-015021-pol2qm74	7481	9	to	to	IN
cord-015021-pol2qm74	7481	10	the	the	DT
cord-015021-pol2qm74	7481	11	rats	rat	NNS
cord-015021-pol2qm74	7481	12	tv	tv	NN
cord-015021-pol2qm74	7481	13	~	~	NFP
cord-015021-pol2qm74	7481	14	ce	ce	NNP
cord-015021-pol2qm74	7481	15	a	a	DT
cord-015021-pol2qm74	7481	16	day	day	NN
cord-015021-pol2qm74	7481	17	for	for	IN
cord-015021-pol2qm74	7481	18	three	three	CD
cord-015021-pol2qm74	7481	19	days	day	NNS
cord-015021-pol2qm74	7481	20	.	.	.
cord-015021-pol2qm74	7482	1	Cirehlatlng	Cirehlatlng	NNP
cord-015021-pol2qm74	7482	2	blood	blood	NN
cord-015021-pol2qm74	7482	3	neutrophyls	neutrophyls	NN
cord-015021-pol2qm74	7482	4	counts	count	NNS
cord-015021-pol2qm74	7482	5	were	be	VBD
cord-015021-pol2qm74	7482	6	determoned	determone	VBN
cord-015021-pol2qm74	7482	7	electronically	electronically	RB
cord-015021-pol2qm74	7482	8	with	with	IN
cord-015021-pol2qm74	7482	9	a	a	DT
cord-015021-pol2qm74	7482	10	hem	hem	NNP
cord-015021-pol2qm74	7482	11	ocytometer	ocytometer	NNP
cord-015021-pol2qm74	7482	12	,	,	,
cord-015021-pol2qm74	7482	13	and	and	CC
cord-015021-pol2qm74	7482	14	blood	blood	NN
cord-015021-pol2qm74	7482	15	smears	smear	NNS
cord-015021-pol2qm74	7482	16	stained	stain	VBN
cord-015021-pol2qm74	7482	17	with	with	IN
cord-015021-pol2qm74	7482	18	May	May	NNP
cord-015021-pol2qm74	7482	19	~	~	NNP
cord-015021-pol2qm74	7482	20	runwaldM.qlemsa	runwaldM.qlemsa	NNP
cord-015021-pol2qm74	7482	21	~	~	CD
cord-015021-pol2qm74	7482	22	taln	taln	NNS
cord-015021-pol2qm74	7482	23	.	.	.
cord-015021-pol2qm74	7483	1	Neutrophyls	Neutrophyls	NNP
cord-015021-pol2qm74	7483	2	functions	function	NNS
cord-015021-pol2qm74	7483	3	in	in	IN
cord-015021-pol2qm74	7483	4	vltro	vltro	NNP
cord-015021-pol2qm74	7483	5	,	,	,
cord-015021-pol2qm74	7483	6	such	such	JJ
cord-015021-pol2qm74	7483	7	as	as	IN
cord-015021-pol2qm74	7483	8	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7483	9	activity	activity	NN
cord-015021-pol2qm74	7483	10	and	and	CC
cord-015021-pol2qm74	7483	11	H	H	NNP
cord-015021-pol2qm74	7483	12	20	20	CD
cord-015021-pol2qm74	7483	13	2	2	CD
cord-015021-pol2qm74	7483	14	producti	producti	NN
cord-015021-pol2qm74	7483	15	on	on	IN
cord-015021-pol2qm74	7483	16	using	use	VBG
cord-015021-pol2qm74	7483	17	the	the	DT
cord-015021-pol2qm74	7483	18	rat	rat	NN
cord-015021-pol2qm74	7483	19	severe	severe	JJ
cord-015021-pol2qm74	7483	20	septic	septic	JJ
cord-015021-pol2qm74	7483	21	model	model	NN
cord-015021-pol2qm74	7483	22	was	be	VBD
cord-015021-pol2qm74	7483	23	analyzvd	analyzvd	NNP
cord-015021-pol2qm74	7483	24	by	by	IN
cord-015021-pol2qm74	7483	25	automated	automate	VBN
cord-015021-pol2qm74	7483	26	flow	flow	NN
cord-015021-pol2qm74	7483	27	cytometri	cytometri	NNP
cord-015021-pol2qm74	7483	28	c	c	NNP
cord-015021-pol2qm74	7483	29	single	single	JJ
cord-015021-pol2qm74	7483	30	cell	cell	NN
cord-015021-pol2qm74	7483	31	-	-	HYPH
cord-015021-pol2qm74	7483	32	analysis	analysis	NN
cord-015021-pol2qm74	7483	33	methods	method	NNS
cord-015021-pol2qm74	7483	34	.	.	.
cord-015021-pol2qm74	7484	1	The	the	DT
cord-015021-pol2qm74	7484	2	reortallty	reortallty	NN
cord-015021-pol2qm74	7484	3	rate	rate	NN
cord-015021-pol2qm74	7484	4	after	after	IN
cord-015021-pol2qm74	7484	5	2	2	CD
cord-015021-pol2qm74	7484	6	weeks	week	NNS
cord-015021-pol2qm74	7484	7	was	be	VBD
cord-015021-pol2qm74	7484	8	significantly	significantly	RB
cord-015021-pol2qm74	7484	9	decreased	decrease	VBN
cord-015021-pol2qm74	7484	10	by	by	IN
cord-015021-pol2qm74	7484	11	administratlon	administratlon	NN
cord-015021-pol2qm74	7484	12	of	of	IN
cord-015021-pol2qm74	7484	13	rh~-CSF(p<0,01).ln	rh~-CSF(p<0,01).ln	NNP
cord-015021-pol2qm74	7484	14	addJtion	addJtion	NNP
cord-015021-pol2qm74	7484	15	,	,	,
cord-015021-pol2qm74	7484	16	a	a	DT
cord-015021-pol2qm74	7484	17	combination	combination	NN
cord-015021-pol2qm74	7484	18	therapy	therapy	NN
cord-015021-pol2qm74	7484	19	of	of	IN
cord-015021-pol2qm74	7484	20	rhG	rhG	NNP
cord-015021-pol2qm74	7484	21	-	-	HYPH
cord-015021-pol2qm74	7484	22	CSF	CSF	NNP
cord-015021-pol2qm74	7484	23	wlte	wlte	NNP
cord-015021-pol2qm74	7484	24	cephern	cephern	NNP
cord-015021-pol2qm74	7484	25	ant	ant	NNP
cord-015021-pol2qm74	7485	1	~biotics(CMZ)showed	~biotics(CMZ)showed	NFP
cord-015021-pol2qm74	7485	2	a	a	DT
cord-015021-pol2qm74	7485	3	significantly	significantly	RB
cord-015021-pol2qm74	7485	4	survive	survive	VBP
cord-015021-pol2qm74	7485	5	]	]	-RRB-
cord-015021-pol2qm74	7485	6	advantage	advantage	NN
cord-015021-pol2qm74	7485	7	and	and	CC
cord-015021-pol2qm74	7486	1	the	the	DT
cord-015021-pol2qm74	7486	2	rate	rate	NN
cord-015021-pol2qm74	7486	3	had	have	VBD
cord-015021-pol2qm74	7486	4	b	b	NN
cord-015021-pol2qm74	7486	5	een	een	NN
cord-015021-pol2qm74	7486	6	reached	reach	VBD
cord-015021-pol2qm74	7486	7	57.1	57.1	CD
cord-015021-pol2qm74	7486	8	%	%	NN
cord-015021-pol2qm74	7486	9	.	.	.
cord-015021-pol2qm74	7487	1	Nextly	nextly	RB
cord-015021-pol2qm74	7487	2	,	,	,
cord-015021-pol2qm74	7487	3	treatn%ent	treatn%ent	CD
cord-015021-pol2qm74	7487	4	wlth	wlth	NN
cord-015021-pol2qm74	7487	5	rhG	rhG	NNP
cord-015021-pol2qm74	7487	6	-	-	HYPH
cord-015021-pol2qm74	7487	7	CSF(S0	CSF(S0	NNP
cord-015021-pol2qm74	7487	8	~	~	NFP
cord-015021-pol2qm74	7487	9	$	$	$
cord-015021-pol2qm74	7487	10	/k9	/k9	NN
cord-015021-pol2qm74	7487	11	body	body	NN
cord-015021-pol2qm74	7488	1	wt)increased	wt)increase	VBD
cord-015021-pol2qm74	7488	2	the	the	DT
cord-015021-pol2qm74	7488	3	nuzaber	nuzaber	NNP
cord-015021-pol2qm74	7488	4	of	of	IN
cord-015021-pol2qm74	7488	5	the	the	DT
cord-015021-pol2qm74	7488	6	peripheral	peripheral	JJ
cord-015021-pol2qm74	7488	7	blood	blood	NN
cord-015021-pol2qm74	7488	8	neutrophJls	neutrophjl	NNS
cord-015021-pol2qm74	7488	9	slgn[fieantly(p<0.01	slgn[fieantly(p<0.01	NN
cord-015021-pol2qm74	7488	10	)	)	-RRB-
cord-015021-pol2qm74	7488	11	.	.	.
cord-015021-pol2qm74	7489	1	iV	iv	LS
cord-015021-pol2qm74	7490	1	~oreover	~oreover	NNP
cord-015021-pol2qm74	7490	2	,	,	,
cord-015021-pol2qm74	7490	3	functions	function	NNS
cord-015021-pol2qm74	7490	4	of	of	IN
cord-015021-pol2qm74	7490	5	neutrophlis	neutrophlis	NNP
cord-015021-pol2qm74	7490	6	which	which	WDT
cord-015021-pol2qm74	7490	7	were	be	VBD
cord-015021-pol2qm74	7490	8	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7490	9	activity	activity	NN
cord-015021-pol2qm74	7490	10	and	and	CC
cord-015021-pol2qm74	7490	11	H2	h2	NN
cord-015021-pol2qm74	7490	12	02	02	CD
cord-015021-pol2qm74	7490	13	p	p	NN
cord-015021-pol2qm74	7490	14	roduction	roduction	NN
cord-015021-pol2qm74	7490	15	were	be	VBD
cord-015021-pol2qm74	7490	16	remarkably	remarkably	RB
cord-015021-pol2qm74	7490	17	enhanced	enhance	VBN
cord-015021-pol2qm74	7490	18	by	by	IN
cord-015021-pol2qm74	7490	19	admlnlstratlon	admlnlstratlon	NN
cord-015021-pol2qm74	7490	20	of	of	IN
cord-015021-pol2qm74	7490	21	rhG	rhG	NNP
cord-015021-pol2qm74	7490	22	-	-	HYPH
cord-015021-pol2qm74	7490	23	CS~(50	CS~(50	NNP
cord-015021-pol2qm74	7490	24	~	~	NFP
cord-015021-pol2qm74	7490	25	9	9	CD
cord-015021-pol2qm74	7490	26	/	/	SYM
cord-015021-pol2qm74	7490	27	ks	ks	NNP
cord-015021-pol2qm74	7490	28	b	b	NNP
cord-015021-pol2qm74	7490	29	ody	ody	NNP
cord-015021-pol2qm74	7490	30	wt	wt	NNP
cord-015021-pol2qm74	7490	31	)	)	-RRB-
cord-015021-pol2qm74	7490	32	(	(	-LRB-
cord-015021-pol2qm74	7490	33	p<0.(15	p<0.(15	NNP
cord-015021-pol2qm74	7490	34	)	)	-RRB-
cord-015021-pol2qm74	7490	35	.	.	.
cord-015021-pol2qm74	7491	1	These	these	DT
cord-015021-pol2qm74	7491	2	findings	finding	NNS
cord-015021-pol2qm74	7491	3	suggest	suggest	VBP
cord-015021-pol2qm74	7491	4	that	that	IN
cord-015021-pol2qm74	7491	5	combination	combination	NN
cord-015021-pol2qm74	7491	6	therapy	therapy	NN
cord-015021-pol2qm74	7491	7	of	of	IN
cord-015021-pol2qm74	7491	8	rhCrCSF	rhCrCSF	NNP
cord-015021-pol2qm74	7491	9	with	with	IN
cord-015021-pol2qm74	7491	10	cephern	cephern	NNP
cord-015021-pol2qm74	7491	11	antib	antib	NNP
cord-015021-pol2qm74	7491	12	iotlcs(CMZ)is	iotlcs(cmz)i	VBZ
cord-015021-pol2qm74	7491	13	an	an	DT
cord-015021-pol2qm74	7491	14	efficient	efficient	JJ
cord-015021-pol2qm74	7491	15	regime	regime	NN
cord-015021-pol2qm74	7491	16	against	against	IN
cord-015021-pol2qm74	7491	17	severe	severe	JJ
cord-015021-pol2qm74	7491	18	infectlons.and	infectlons.and	NFP
cord-015021-pol2qm74	7491	19	the	the	DT
cord-015021-pol2qm74	7491	20	increased	increase	VBN
cord-015021-pol2qm74	7491	21	ne	ne	NNP
cord-015021-pol2qm74	7491	22	utrophils	utrophils	NNP
cord-015021-pol2qm74	7491	23	counts	count	VBZ
cord-015021-pol2qm74	7491	24	and	and	CC
cord-015021-pol2qm74	7491	25	enhanced	enhance	VBN
cord-015021-pol2qm74	7491	26	neutrophiis	neutrophiis	JJ
cord-015021-pol2qm74	7491	27	functions	function	NNS
cord-015021-pol2qm74	7491	28	were	be	VBD
cord-015021-pol2qm74	7491	29	played	play	VBN
cord-015021-pol2qm74	7491	30	a	a	DT
cord-015021-pol2qm74	7491	31	important	important	JJ
cord-015021-pol2qm74	7491	32	ro	ro	NNP
cord-015021-pol2qm74	7491	33	le	le	NNP
cord-015021-pol2qm74	7491	34	about	about	IN
cord-015021-pol2qm74	7491	35	the	the	DT
cord-015021-pol2qm74	7491	36	survival	survival	NN
cord-015021-pol2qm74	7491	37	advantage	advantage	NN
cord-015021-pol2qm74	7491	38	.	.	.
cord-015021-pol2qm74	7492	1	Granulocyte	Granulocyte	NNP
cord-015021-pol2qm74	7492	2	macrophage	macrophage	NN
cord-015021-pol2qm74	7492	3	colony	colony	NN
cord-015021-pol2qm74	7492	4	-	-	HYPH
cord-015021-pol2qm74	7492	5	stimulating	stimulate	VBG
cord-015021-pol2qm74	7492	6	factor	factor	NN
cord-015021-pol2qm74	7492	7	(	(	-LRB-
cord-015021-pol2qm74	7492	8	GM	GM	NNP
cord-015021-pol2qm74	7492	9	-	-	HYPH
cord-015021-pol2qm74	7492	10	CSF	CSF	NNP
cord-015021-pol2qm74	7492	11	)	)	-RRB-
cord-015021-pol2qm74	7492	12	is	be	VBZ
cord-015021-pol2qm74	7492	13	a	a	DT
cord-015021-pol2qm74	7492	14	haematopoietic	haematopoietic	JJ
cord-015021-pol2qm74	7492	15	growth	growth	NN
cord-015021-pol2qm74	7492	16	factor	factor	NN
cord-015021-pol2qm74	7492	17	active	active	JJ
cord-015021-pol2qm74	7492	18	on	on	IN
cord-015021-pol2qm74	7492	19	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7492	20	and	and	CC
cord-015021-pol2qm74	7492	21	macrophages	macrophage	NNS
cord-015021-pol2qm74	7492	22	.	.	.
cord-015021-pol2qm74	7493	1	Leukopenia	leukopenia	NN
cord-015021-pol2qm74	7493	2	often	often	RB
cord-015021-pol2qm74	7493	3	occurs	occur	VBZ
cord-015021-pol2qm74	7493	4	following	follow	VBG
cord-015021-pol2qm74	7493	5	renal	renal	JJ
cord-015021-pol2qm74	7493	6	transplantation	transplantation	NN
cord-015021-pol2qm74	7493	7	and	and	CC
cord-015021-pol2qm74	7493	8	can	can	MD
cord-015021-pol2qm74	7493	9	be	be	VB
cord-015021-pol2qm74	7493	10	associated	associate	VBN
cord-015021-pol2qm74	7493	11	with	with	IN
cord-015021-pol2qm74	7493	12	infection	infection	NN
cord-015021-pol2qm74	7493	13	and/or	and/or	CC
cord-015021-pol2qm74	7493	14	the	the	DT
cord-015021-pol2qm74	7493	15	myelosuppressive	myelosuppressive	JJ
cord-015021-pol2qm74	7493	16	effect	effect	NN
cord-015021-pol2qm74	7493	17	of	of	IN
cord-015021-pol2qm74	7493	18	azathioprine	azathioprine	NN
cord-015021-pol2qm74	7493	19	.	.	.
cord-015021-pol2qm74	7494	1	Aim	aim	VB
cord-015021-pol2qm74	7494	2	:	:	:
cord-015021-pol2qm74	7494	3	We	-PRON-	PRP
cord-015021-pol2qm74	7494	4	report	report	VBP
cord-015021-pol2qm74	7494	5	the	the	DT
cord-015021-pol2qm74	7494	6	use	use	NN
cord-015021-pol2qm74	7494	7	of	of	IN
cord-015021-pol2qm74	7494	8	GM	GM	NNP
cord-015021-pol2qm74	7494	9	-	-	HYPH
cord-015021-pol2qm74	7494	10	CSF	CSF	NNP
cord-015021-pol2qm74	7494	11	in	in	IN
cord-015021-pol2qm74	7494	12	17	17	CD
cord-015021-pol2qm74	7494	13	renal	renal	JJ
cord-015021-pol2qm74	7494	14	allograft	allograft	NN
cord-015021-pol2qm74	7494	15	recipients	recipient	NNS
cord-015021-pol2qm74	7494	16	with	with	IN
cord-015021-pol2qm74	7494	17	leukopenia	leukopenia	NN
cord-015021-pol2qm74	7494	18	.	.	.
cord-015021-pol2qm74	7495	1	Nonglycosylated	Nonglycosylated	NNP
cord-015021-pol2qm74	7496	1	recombinant	recombinant	JJ
cord-015021-pol2qm74	7496	2	GM	GM	NNP
cord-015021-pol2qm74	7496	3	-	-	HYPH
cord-015021-pol2qm74	7496	4	CSF	CSF	NNP
cord-015021-pol2qm74	7496	5	was	be	VBD
cord-015021-pol2qm74	7496	6	obtained	obtain	VBN
cord-015021-pol2qm74	7496	7	from	from	IN
cord-015021-pol2qm74	7496	8	E.	E.	NNP
cord-015021-pol2qm74	7496	9	coli	coli	NNS
cord-015021-pol2qm74	7496	10	transvected	transvecte	VBN
cord-015021-pol2qm74	7496	11	by	by	IN
cord-015021-pol2qm74	7496	12	human	human	JJ
cord-015021-pol2qm74	7496	13	GM	GM	NNP
cord-015021-pol2qm74	7496	14	-	-	HYPH
cord-015021-pol2qm74	7496	15	CSF	csf	NN
cord-015021-pol2qm74	7496	16	gene	gene	NN
cord-015021-pol2qm74	7496	17	.	.	.
cord-015021-pol2qm74	7497	1	M	M	NNP
cord-015021-pol2qm74	7497	2	~	~	CD
cord-015021-pol2qm74	7497	3	terial	terial	NNP
cord-015021-pol2qm74	7497	4	~,nd	~,nd	NNP
cord-015021-pol2qm74	7497	5	Methods	Methods	NNP
cord-015021-pol2qm74	7497	6	:	:	:
cord-015021-pol2qm74	7497	7	Written	write	VBN
cord-015021-pol2qm74	7498	1	informed	informed	JJ
cord-015021-pol2qm74	7498	2	consent	consent	NN
cord-015021-pol2qm74	7498	3	was	be	VBD
cord-015021-pol2qm74	7498	4	obtained	obtain	VBN
cord-015021-pol2qm74	7498	5	from	from	IN
cord-015021-pol2qm74	7498	6	all	all	DT
cord-015021-pol2qm74	7498	7	patients	patient	NNS
cord-015021-pol2qm74	7498	8	.	.	.
cord-015021-pol2qm74	7499	1	Patients	patient	NNS
cord-015021-pol2qm74	7499	2	were	be	VBD
cord-015021-pol2qm74	7499	3	suffering	suffer	VBG
cord-015021-pol2qm74	7499	4	from	from	IN
cord-015021-pol2qm74	7499	5	toxic	toxic	JJ
cord-015021-pol2qm74	7499	6	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7500	1	(	(	-LRB-
cord-015021-pol2qm74	7500	2	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7500	3	<	<	XX
cord-015021-pol2qm74	7500	4	500	500	CD
cord-015021-pol2qm74	7500	5	/	/	SYM
cord-015021-pol2qm74	7500	6	mm	mm	NNP
cord-015021-pol2qm74	7500	7	3	3	CD
cord-015021-pol2qm74	7500	8	)	)	-RRB-
cord-015021-pol2qm74	7500	9	with	with	IN
cord-015021-pol2qm74	7500	10	medullar	medullar	JJ
cord-015021-pol2qm74	7500	11	hypocellularity	hypocellularity	NN
cord-015021-pol2qm74	7500	12	on	on	IN
cord-015021-pol2qm74	7500	13	bone	bone	NN
cord-015021-pol2qm74	7500	14	marrow	marrow	NN
cord-015021-pol2qm74	7500	15	aspiration	aspiration	NN
cord-015021-pol2qm74	7500	16	,	,	,
cord-015021-pol2qm74	7500	17	or	or	CC
cord-015021-pol2qm74	7500	18	leukopenia	leukopenia	NN
cord-015021-pol2qm74	7500	19	(	(	-LRB-
cord-015021-pol2qm74	7500	20	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7500	21	<	<	XX
cord-015021-pol2qm74	7500	22	1000	1000	CD
cord-015021-pol2qm74	7501	1	/ram	/ram	CD
cord-015021-pol2qm74	7501	2	3	3	LS
cord-015021-pol2qm74	7501	3	)	)	-RRB-
cord-015021-pol2qm74	7501	4	with	with	IN
cord-015021-pol2qm74	7501	5	cytomegalovirus	cytomegalovirus	JJ
cord-015021-pol2qm74	7501	6	infection	infection	NN
cord-015021-pol2qm74	7501	7	requiring	require	VBG
cord-015021-pol2qm74	7501	8	ganciclovir	ganciclovir	NNP
cord-015021-pol2qm74	7501	9	administTation	administtation	NN
cord-015021-pol2qm74	7501	10	.	.	.
cord-015021-pol2qm74	7502	1	GM	GM	NNP
cord-015021-pol2qm74	7502	2	-	-	HYPH
cord-015021-pol2qm74	7502	3	CSF	CSF	NNP
cord-015021-pol2qm74	7502	4	was	be	VBD
cord-015021-pol2qm74	7502	5	given	give	VBN
cord-015021-pol2qm74	7502	6	subcutaneously	subcutaneously	RB
cord-015021-pol2qm74	7502	7	at	at	IN
cord-015021-pol2qm74	7502	8	a	a	DT
cord-015021-pol2qm74	7502	9	dally	dally	NN
cord-015021-pol2qm74	7502	10	dose	dose	NN
cord-015021-pol2qm74	7502	11	of	of	IN
cord-015021-pol2qm74	7502	12	2	2	CD
cord-015021-pol2qm74	7502	13	to	to	TO
cord-015021-pol2qm74	7502	14	5	5	CD
cord-015021-pol2qm74	7502	15	mcg	mcg	NN
cord-015021-pol2qm74	7502	16	/	/	SYM
cord-015021-pol2qm74	7502	17	kg	kg	NNP
cord-015021-pol2qm74	7502	18	/	/	SYM
cord-015021-pol2qm74	7502	19	day	day	NN
cord-015021-pol2qm74	7502	20	,	,	,
cord-015021-pol2qm74	7502	21	according	accord	VBG
cord-015021-pol2qm74	7502	22	to	to	IN
cord-015021-pol2qm74	7502	23	renal	renal	JJ
cord-015021-pol2qm74	7502	24	function	function	NN
cord-015021-pol2qm74	7502	25	.	.	.
cord-015021-pol2qm74	7503	1	Results	result	NNS
cord-015021-pol2qm74	7503	2	:	:	:
cord-015021-pol2qm74	7504	1	In	in	IN
cord-015021-pol2qm74	7504	2	all	all	DT
cord-015021-pol2qm74	7504	3	cases	case	NNS
cord-015021-pol2qm74	7504	4	,	,	,
cord-015021-pol2qm74	7504	5	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7504	6	counts	count	NNS
cord-015021-pol2qm74	7504	7	returned	return	VBD
cord-015021-pol2qm74	7504	8	to	to	IN
cord-015021-pol2qm74	7504	9	normal	normal	JJ
cord-015021-pol2qm74	7504	10	levels	level	NNS
cord-015021-pol2qm74	7504	11	within	within	IN
cord-015021-pol2qm74	7504	12	1	1	CD
cord-015021-pol2qm74	7504	13	to	to	IN
cord-015021-pol2qm74	7504	14	4	4	CD
cord-015021-pol2qm74	7504	15	days	day	NNS
cord-015021-pol2qm74	7504	16	.	.	.
cord-015021-pol2qm74	7505	1	In	in	IN
cord-015021-pol2qm74	7505	2	most	most	JJS
cord-015021-pol2qm74	7505	3	of	of	IN
cord-015021-pol2qm74	7505	4	them	-PRON-	PRP
cord-015021-pol2qm74	7505	5	,	,	,
cord-015021-pol2qm74	7505	6	spectacular	spectacular	JJ
cord-015021-pol2qm74	7505	7	correction	correction	NN
cord-015021-pol2qm74	7505	8	was	be	VBD
cord-015021-pol2qm74	7505	9	observed	observe	VBN
cord-015021-pol2qm74	7505	10	within	within	IN
cord-015021-pol2qm74	7505	11	24	24	CD
cord-015021-pol2qm74	7505	12	hours	hour	NNS
cord-015021-pol2qm74	7505	13	,	,	,
cord-015021-pol2qm74	7505	14	with	with	IN
cord-015021-pol2qm74	7505	15	a	a	DT
cord-015021-pol2qm74	7505	16	single	single	JJ
cord-015021-pol2qm74	7505	17	injection	injection	NN
cord-015021-pol2qm74	7505	18	.	.	.
cord-015021-pol2qm74	7506	1	Adverse	adverse	JJ
cord-015021-pol2qm74	7506	2	events	event	NNS
cord-015021-pol2qm74	7506	3	due	due	JJ
cord-015021-pol2qm74	7506	4	to	to	IN
cord-015021-pol2qm74	7506	5	GM	GM	NNP
cord-015021-pol2qm74	7506	6	-	-	HYPH
cord-015021-pol2qm74	7506	7	CSF	CSF	NNP
cord-015021-pol2qm74	7506	8	at	at	IN
cord-015021-pol2qm74	7506	9	this	this	DT
cord-015021-pol2qm74	7506	10	dose	dose	NN
cord-015021-pol2qm74	7506	11	were	be	VBD
cord-015021-pol2qm74	7506	12	mild	mild	JJ
cord-015021-pol2qm74	7506	13	and	and	CC
cord-015021-pol2qm74	7506	14	easily	easily	RB
cord-015021-pol2qm74	7506	15	managed	manage	VBN
cord-015021-pol2qm74	7506	16	(	(	-LRB-
cord-015021-pol2qm74	7506	17	2	2	CD
cord-015021-pol2qm74	7506	18	cases	case	NNS
cord-015021-pol2qm74	7506	19	of	of	IN
cord-015021-pol2qm74	7506	20	bone	bone	NN
cord-015021-pol2qm74	7506	21	pain	pain	NN
cord-015021-pol2qm74	7506	22	treated	treat	VBN
cord-015021-pol2qm74	7506	23	with	with	IN
cord-015021-pol2qm74	7506	24	paracetamol	paracetamol	NNP
cord-015021-pol2qm74	7506	25	)	)	-RRB-
cord-015021-pol2qm74	7506	26	.	.	.
cord-015021-pol2qm74	7507	1	One	one	CD
cord-015021-pol2qm74	7507	2	acute	acute	JJ
cord-015021-pol2qm74	7507	3	rejection	rejection	NN
cord-015021-pol2qm74	7507	4	episode	episode	NN
cord-015021-pol2qm74	7507	5	was	be	VBD
cord-015021-pol2qm74	7507	6	observed	observe	VBN
cord-015021-pol2qm74	7507	7	after	after	IN
cord-015021-pol2qm74	7507	8	correction	correction	NN
cord-015021-pol2qm74	7507	9	of	of	IN
cord-015021-pol2qm74	7507	10	leukopenia	leukopenia	NN
cord-015021-pol2qm74	7507	11	.	.	.
cord-015021-pol2qm74	7508	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	7508	2	:	:	:
cord-015021-pol2qm74	7509	1	On	on	IN
cord-015021-pol2qm74	7509	2	the	the	DT
cord-015021-pol2qm74	7509	3	basis	basis	NN
cord-015021-pol2qm74	7509	4	of	of	IN
cord-015021-pol2qm74	7509	5	this	this	DT
cord-015021-pol2qm74	7509	6	study	study	NN
cord-015021-pol2qm74	7509	7	,	,	,
cord-015021-pol2qm74	7509	8	it	-PRON-	PRP
cord-015021-pol2qm74	7509	9	appears	appear	VBZ
cord-015021-pol2qm74	7509	10	that	that	IN
cord-015021-pol2qm74	7509	11	GM	GM	NNP
cord-015021-pol2qm74	7509	12	-	-	HYPH
cord-015021-pol2qm74	7509	13	CSF	CSF	NNP
cord-015021-pol2qm74	7509	14	at	at	IN
cord-015021-pol2qm74	7509	15	a	a	DT
cord-015021-pol2qm74	7509	16	dose	dose	NN
cord-015021-pol2qm74	7509	17	below	below	IN
cord-015021-pol2qm74	7509	18	5	5	CD
cord-015021-pol2qm74	7509	19	mcg	mcg	NNP
cord-015021-pol2qm74	7509	20	/	/	SYM
cord-015021-pol2qm74	7509	21	kg	kg	NNP
cord-015021-pol2qm74	7509	22	/	/	SYM
cord-015021-pol2qm74	7509	23	day	day	NN
cord-015021-pol2qm74	7509	24	is	be	VBZ
cord-015021-pol2qm74	7509	25	an	an	DT
cord-015021-pol2qm74	7509	26	effective	effective	JJ
cord-015021-pol2qm74	7509	27	treatment	treatment	NN
cord-015021-pol2qm74	7509	28	for	for	IN
cord-015021-pol2qm74	7509	29	renal	renal	JJ
cord-015021-pol2qm74	7509	30	transplant	transplant	NN
cord-015021-pol2qm74	7509	31	recipients	recipient	NNS
cord-015021-pol2qm74	7509	32	with	with	IN
cord-015021-pol2qm74	7509	33	leukopenia	leukopenia	NN
cord-015021-pol2qm74	7509	34	associated	associate	VBN
cord-015021-pol2qm74	7509	35	with	with	IN
cord-015021-pol2qm74	7509	36	CMV	CMV	NNP
cord-015021-pol2qm74	7509	37	infection	infection	NN
cord-015021-pol2qm74	7509	38	or	or	CC
cord-015021-pol2qm74	7509	39	toxic	toxic	JJ
cord-015021-pol2qm74	7509	40	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7509	41	.	.	.
cord-015021-pol2qm74	7510	1	Department	Department	NNP
cord-015021-pol2qm74	7510	2	of	of	IN
cord-015021-pol2qm74	7510	3	Nephrology	Nephrology	NNP
cord-015021-pol2qm74	7510	4	,	,	,
cord-015021-pol2qm74	7510	5	161	161	CD
cord-015021-pol2qm74	7510	6	,	,	,
cord-015021-pol2qm74	7510	7	rue	rue	FW
cord-015021-pol2qm74	7510	8	de	de	FW
cord-015021-pol2qm74	7510	9	S	S	NNP
cord-015021-pol2qm74	7510	10	~	~	CD
cord-015021-pol2qm74	7510	11	vres	vre	NNS
cord-015021-pol2qm74	7510	12	,	,	,
cord-015021-pol2qm74	7510	13	HOPITAL	HOPITAL	NNP
cord-015021-pol2qm74	7510	14	NECKER	NECKER	NNP
cord-015021-pol2qm74	7510	15	,	,	,
cord-015021-pol2qm74	7510	16	75743	75743	CD
cord-015021-pol2qm74	7510	17	PARIS	PARIS	NNP
cord-015021-pol2qm74	7510	18	,	,	,
cord-015021-pol2qm74	7510	19	FRANCE	FRANCE	NNP
cord-015021-pol2qm74	7510	20	.	.	.
cord-015021-pol2qm74	7511	1	Changes	change	NNS
cord-015021-pol2qm74	7511	2	in	in	IN
cord-015021-pol2qm74	7511	3	serum	serum	NN
cord-015021-pol2qm74	7511	4	G	G	NNP
cord-015021-pol2qm74	7511	5	-	-	HYPH
cord-015021-pol2qm74	7511	6	CSF	CSF	NNP
cord-015021-pol2qm74	7511	7	and	and	CC
cord-015021-pol2qm74	7511	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	7511	9	after	after	IN
cord-015021-pol2qm74	7511	10	surgical	surgical	JJ
cord-015021-pol2qm74	7511	11	intervention	intervention	NN
cord-015021-pol2qm74	7511	12	Hitoshi	Hitoshi	NNP
cord-015021-pol2qm74	7511	13	Toda	Toda	NNP
cord-015021-pol2qm74	7511	14	1	1	CD
cord-015021-pol2qm74	7511	15	,	,	,
cord-015021-pol2qm74	7511	16	Atsuo	Atsuo	NNP
cord-015021-pol2qm74	7511	17	Murata	Murata	NNP
cord-015021-pol2qm74	7511	18	1	1	CD
cord-015021-pol2qm74	7511	19	,	,	,
cord-015021-pol2qm74	7511	20	Hidewaki	Hidewaki	NNP
cord-015021-pol2qm74	7511	21	Nakagawa	Nakagawa	NNP
cord-015021-pol2qm74	7511	22	1	1	CD
cord-015021-pol2qm74	7511	23	,	,	,
cord-015021-pol2qm74	7511	24	Takesada	Takesada	NNP
cord-015021-pol2qm74	7511	25	Mori	Mori	NNP
cord-015021-pol2qm74	7511	26	1	1	CD
cord-015021-pol2qm74	7511	27	,	,	,
cord-015021-pol2qm74	7511	28	Nariaki	Nariaki	NNP
cord-015021-pol2qm74	7511	29	Matsuura	Matsuura	NNP
cord-015021-pol2qm74	7511	30	2	2	CD
cord-015021-pol2qm74	7511	31	1Osaka	1Osaka	NNP
cord-015021-pol2qm74	7511	32	University	University	NNP
cord-015021-pol2qm74	7511	33	Medical	Medical	NNP
cord-015021-pol2qm74	7511	34	School	School	NNP
cord-015021-pol2qm74	7511	35	,	,	,
cord-015021-pol2qm74	7511	36	Osaka	Osaka	NNP
cord-015021-pol2qm74	7511	37	,	,	,
cord-015021-pol2qm74	7511	38	2Wakayama	2Wakayama	NNP
cord-015021-pol2qm74	7511	39	Medical	Medical	NNP
cord-015021-pol2qm74	7511	40	School	School	NNP
cord-015021-pol2qm74	7511	41	,	,	,
cord-015021-pol2qm74	7511	42	Wakayama	Wakayama	NNP
cord-015021-pol2qm74	7511	43	,	,	,
cord-015021-pol2qm74	7511	44	Japan	Japan	NNP
cord-015021-pol2qm74	7512	1	We	-PRON-	PRP
cord-015021-pol2qm74	7512	2	measured	measure	VBD
cord-015021-pol2qm74	7512	3	serum	serum	NN
cord-015021-pol2qm74	7512	4	immunoreactive	immunoreactive	NNP
cord-015021-pol2qm74	7512	5	interleukin	interleukin	NNP
cord-015021-pol2qm74	7512	6	6	6	CD
cord-015021-pol2qm74	7512	7	(	(	-LRB-
cord-015021-pol2qm74	7512	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	7512	9	)	)	-RRB-
cord-015021-pol2qm74	7512	10	and	and	CC
cord-015021-pol2qm74	7512	11	granulocyte	granulocyte	NN
cord-015021-pol2qm74	7512	12	colony	colony	NN
cord-015021-pol2qm74	7512	13	-	-	HYPH
cord-015021-pol2qm74	7512	14	stimulating	stimulate	VBG
cord-015021-pol2qm74	7512	15	factor	factor	NN
cord-015021-pol2qm74	7513	1	(	(	-LRB-
cord-015021-pol2qm74	7513	2	G	G	NNP
cord-015021-pol2qm74	7513	3	-	-	HYPH
cord-015021-pol2qm74	7513	4	CSF	CSF	NNP
cord-015021-pol2qm74	7513	5	)	)	-RRB-
cord-015021-pol2qm74	7513	6	levels	level	NNS
cord-015021-pol2qm74	7513	7	of	of	IN
cord-015021-pol2qm74	7513	8	the	the	DT
cord-015021-pol2qm74	7513	9	patients	patient	NNS
cord-015021-pol2qm74	7513	10	undergoing	undergo	VBG
cord-015021-pol2qm74	7513	11	major	major	JJ
cord-015021-pol2qm74	7513	12	thoraco	thoraco	NNS
cord-015021-pol2qm74	7513	13	-	-	HYPH
cord-015021-pol2qm74	7513	14	abdominal	abdominal	JJ
cord-015021-pol2qm74	7513	15	surgery	surgery	NN
cord-015021-pol2qm74	7513	16	for	for	IN
cord-015021-pol2qm74	7513	17	esophageal	esophageal	JJ
cord-015021-pol2qm74	7513	18	cancer	cancer	NN
cord-015021-pol2qm74	7513	19	.	.	.
cord-015021-pol2qm74	7514	1	Serum	serum	NN
cord-015021-pol2qm74	7514	2	samples	sample	NNS
cord-015021-pol2qm74	7514	3	were	be	VBD
cord-015021-pol2qm74	7514	4	collected	collect	VBN
cord-015021-pol2qm74	7514	5	from	from	IN
cord-015021-pol2qm74	7514	6	eight	eight	CD
cord-015021-pol2qm74	7514	7	patients	patient	NNS
cord-015021-pol2qm74	7514	8	on	on	IN
cord-015021-pol2qm74	7514	9	the	the	DT
cord-015021-pol2qm74	7514	10	day	day	NN
cord-015021-pol2qm74	7514	11	before	before	IN
cord-015021-pol2qm74	7514	12	surgery	surgery	NN
cord-015021-pol2qm74	7514	13	,	,	,
cord-015021-pol2qm74	7514	14	at	at	IN
cord-015021-pol2qm74	7514	15	the	the	DT
cord-015021-pol2qm74	7514	16	time	time	NN
cord-015021-pol2qm74	7514	17	of	of	IN
cord-015021-pol2qm74	7514	18	operation	operation	NN
cord-015021-pol2qm74	7514	19	,	,	,
cord-015021-pol2qm74	7514	20	and	and	CC
cord-015021-pol2qm74	7514	21	thereafter	thereafter	RB
cord-015021-pol2qm74	7514	22	at	at	IN
cord-015021-pol2qm74	7514	23	suitable	suitable	JJ
cord-015021-pol2qm74	7514	24	intervals	interval	NNS
cord-015021-pol2qm74	7514	25	for	for	IN
cord-015021-pol2qm74	7514	26	one	one	CD
cord-015021-pol2qm74	7514	27	week	week	NN
cord-015021-pol2qm74	7514	28	.	.	.
cord-015021-pol2qm74	7515	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	7515	2	and	and	CC
cord-015021-pol2qm74	7515	3	G	G	NNP
cord-015021-pol2qm74	7515	4	-	-	HYPH
cord-015021-pol2qm74	7515	5	CSF	CSF	NNP
cord-015021-pol2qm74	7515	6	were	be	VBD
cord-015021-pol2qm74	7515	7	measured	measure	VBN
cord-015021-pol2qm74	7515	8	by	by	IN
cord-015021-pol2qm74	7515	9	means	mean	NNS
cord-015021-pol2qm74	7515	10	of	of	IN
cord-015021-pol2qm74	7515	11	enzyme	enzyme	NN
cord-015021-pol2qm74	7515	12	linked	link	VBN
cord-015021-pol2qm74	7515	13	immunoassay	immunoassay	NN
cord-015021-pol2qm74	7515	14	.	.	.
cord-015021-pol2qm74	7516	1	The	the	DT
cord-015021-pol2qm74	7516	2	normal	normal	JJ
cord-015021-pol2qm74	7516	3	range	range	NN
cord-015021-pol2qm74	7516	4	of	of	IN
cord-015021-pol2qm74	7516	5	serum	serum	NN
cord-015021-pol2qm74	7516	6	]	]	-RRB-
cord-015021-pol2qm74	7516	7	L-6	L-6	NNP
cord-015021-pol2qm74	7516	8	was	be	VBD
cord-015021-pol2qm74	7516	9	less	less	JJR
cord-015021-pol2qm74	7516	10	than	than	IN
cord-015021-pol2qm74	7516	11	2	2	CD
cord-015021-pol2qm74	7516	12	pg	pg	NN
cord-015021-pol2qm74	7516	13	/	/	SYM
cord-015021-pol2qm74	7516	14	ml	ml	NN
cord-015021-pol2qm74	7516	15	and	and	CC
cord-015021-pol2qm74	7516	16	G	G	NNP
cord-015021-pol2qm74	7516	17	-	-	HYPH
cord-015021-pol2qm74	7516	18	CSF	CSF	NNP
cord-015021-pol2qm74	7517	1	less	less	JJR
cord-015021-pol2qm74	7517	2	than	than	IN
cord-015021-pol2qm74	7517	3	4	4	CD
cord-015021-pol2qm74	7517	4	pg	pg	NN
cord-015021-pol2qm74	7517	5	/	/	SYM
cord-015021-pol2qm74	7517	6	ml	ml	NN
cord-015021-pol2qm74	7517	7	.	.	.
cord-015021-pol2qm74	7518	1	Values	value	NNS
cord-015021-pol2qm74	7518	2	between	between	IN
cord-015021-pol2qm74	7518	3	groups	group	NNS
cord-015021-pol2qm74	7518	4	were	be	VBD
cord-015021-pol2qm74	7518	5	compared	compare	VBN
cord-015021-pol2qm74	7518	6	with	with	IN
cord-015021-pol2qm74	7518	7	linear	linear	JJ
cord-015021-pol2qm74	7518	8	regression	regression	NN
cord-015021-pol2qm74	7518	9	analysis	analysis	NN
cord-015021-pol2qm74	7518	10	.	.	.
cord-015021-pol2qm74	7519	1	Both	both	DT
cord-015021-pol2qm74	7519	2	serum	serum	NN
cord-015021-pol2qm74	7519	3	G	G	NNP
cord-015021-pol2qm74	7519	4	-	-	HYPH
cord-015021-pol2qm74	7519	5	CSF	CSF	NNP
cord-015021-pol2qm74	7519	6	and	and	CC
cord-015021-pol2qm74	7519	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	7519	8	levels	level	NNS
cord-015021-pol2qm74	7519	9	reached	reach	VBD
cord-015021-pol2qm74	7519	10	their	-PRON-	PRP$
cord-015021-pol2qm74	7519	11	maximal	maximal	JJ
cord-015021-pol2qm74	7519	12	levels	level	NNS
cord-015021-pol2qm74	7519	13	at	at	IN
cord-015021-pol2qm74	7519	14	the	the	DT
cord-015021-pol2qm74	7519	15	first	first	JJ
cord-015021-pol2qm74	7519	16	postoperative	postoperative	JJ
cord-015021-pol2qm74	7519	17	day	day	NN
cord-015021-pol2qm74	7519	18	and	and	CC
cord-015021-pol2qm74	7519	19	decreased	decrease	VBD
cord-015021-pol2qm74	7519	20	thereafter	thereafter	RB
cord-015021-pol2qm74	7519	21	.	.	.
cord-015021-pol2qm74	7520	1	The	the	DT
cord-015021-pol2qm74	7520	2	correlation	correlation	NN
cord-015021-pol2qm74	7520	3	between	between	IN
cord-015021-pol2qm74	7520	4	G	G	NNP
cord-015021-pol2qm74	7520	5	-	-	HYPH
cord-015021-pol2qm74	7520	6	CSF	CSF	NNP
cord-015021-pol2qm74	7520	7	(	(	-LRB-
cord-015021-pol2qm74	7520	8	y	y	NNP
cord-015021-pol2qm74	7520	9	)	)	-RRB-
cord-015021-pol2qm74	7520	10	and	and	CC
cord-015021-pol2qm74	7520	11	IL-6	IL-6	NNP
cord-015021-pol2qm74	7520	12	(	(	-LRB-
cord-015021-pol2qm74	7520	13	x	x	NN
cord-015021-pol2qm74	7520	14	)	)	-RRB-
cord-015021-pol2qm74	7520	15	was	be	VBD
cord-015021-pol2qm74	7520	16	y=3.28x+6.16	y=3.28x+6.16	VBN
cord-015021-pol2qm74	7520	17	(	(	-LRB-
cord-015021-pol2qm74	7520	18	r=0.786	r=0.786	NNP
cord-015021-pol2qm74	7520	19	,	,	,
cord-015021-pol2qm74	7520	20	n=86	n=86	NNP
cord-015021-pol2qm74	7520	21	,	,	,
cord-015021-pol2qm74	7520	22	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	7520	23	)	)	-RRB-
cord-015021-pol2qm74	7520	24	,	,	,
cord-015021-pol2qm74	7520	25	showing	show	VBG
cord-015021-pol2qm74	7520	26	a	a	DT
cord-015021-pol2qm74	7520	27	significant	significant	JJ
cord-015021-pol2qm74	7520	28	correlation	correlation	NN
cord-015021-pol2qm74	7520	29	.	.	.
cord-015021-pol2qm74	7521	1	In	in	IN
cord-015021-pol2qm74	7521	2	the	the	DT
cord-015021-pol2qm74	7521	3	case	case	NN
cord-015021-pol2qm74	7521	4	who	who	WP
cord-015021-pol2qm74	7521	5	suffered	suffer	VBD
cord-015021-pol2qm74	7521	6	from	from	IN
cord-015021-pol2qm74	7521	7	aspiration	aspiration	NN
cord-015021-pol2qm74	7521	8	pneumonia	pneumonia	NN
cord-015021-pol2qm74	7521	9	and	and	CC
cord-015021-pol2qm74	7521	10	ARDS	ARDS	NNP
cord-015021-pol2qm74	7521	11	at	at	IN
cord-015021-pol2qm74	7521	12	the	the	DT
cord-015021-pol2qm74	7521	13	second	second	JJ
cord-015021-pol2qm74	7521	14	postoperative	postoperative	JJ
cord-015021-pol2qm74	7521	15	day	day	NN
cord-015021-pol2qm74	7521	16	,	,	,
cord-015021-pol2qm74	7521	17	the	the	DT
cord-015021-pol2qm74	7521	18	peak	peak	NN
cord-015021-pol2qm74	7521	19	level	level	NN
cord-015021-pol2qm74	7521	20	of	of	IN
cord-015021-pol2qm74	7521	21	IL-6	IL-6	NNP
cord-015021-pol2qm74	7521	22	was	be	VBD
cord-015021-pol2qm74	7521	23	50	50	CD
cord-015021-pol2qm74	7521	24	pg	pg	NN
cord-015021-pol2qm74	7521	25	/	/	SYM
cord-015021-pol2qm74	7521	26	ml	ml	NN
cord-015021-pol2qm74	7521	27	and	and	CC
cord-015021-pol2qm74	7521	28	G	G	NNP
cord-015021-pol2qm74	7521	29	-	-	HYPH
cord-015021-pol2qm74	7521	30	CSF	CSF	NNP
cord-015021-pol2qm74	7521	31	69	69	CD
cord-015021-pol2qm74	7521	32	pg	pg	NN
cord-015021-pol2qm74	7521	33	/	/	SYM
cord-015021-pol2qm74	7521	34	ml	ml	NN
cord-015021-pol2qm74	7521	35	respectively	respectively	RB
cord-015021-pol2qm74	7521	36	.	.	.
cord-015021-pol2qm74	7522	1	The	the	DT
cord-015021-pol2qm74	7522	2	estimated	estimate	VBN
cord-015021-pol2qm74	7522	3	value	value	NN
cord-015021-pol2qm74	7522	4	of	of	IN
cord-015021-pol2qm74	7522	5	G	G	NNP
cord-015021-pol2qm74	7522	6	-	-	HYPH
cord-015021-pol2qm74	7522	7	CSF	CSF	NNP
cord-015021-pol2qm74	7522	8	was	be	VBD
cord-015021-pol2qm74	7523	1	171	171	CD
cord-015021-pol2qm74	7523	2	pg	pg	NNP
cord-015021-pol2qm74	7523	3	/	/	SYM
cord-015021-pol2qm74	7523	4	mi	mi	NNP
cord-015021-pol2qm74	7523	5	by	by	IN
cord-015021-pol2qm74	7523	6	the	the	DT
cord-015021-pol2qm74	7523	7	regression	regression	NN
cord-015021-pol2qm74	7523	8	equation	equation	NN
cord-015021-pol2qm74	7523	9	.	.	.
cord-015021-pol2qm74	7524	1	This	this	DT
cord-015021-pol2qm74	7524	2	means	mean	VBZ
cord-015021-pol2qm74	7524	3	the	the	DT
cord-015021-pol2qm74	7524	4	real	real	JJ
cord-015021-pol2qm74	7524	5	G	G	NNP
cord-015021-pol2qm74	7524	6	-	-	HYPH
cord-015021-pol2qm74	7524	7	CSE	CSE	NNP
cord-015021-pol2qm74	7524	8	level	level	NN
cord-015021-pol2qm74	7524	9	was	be	VBD
cord-015021-pol2qm74	7524	10	less	less	JJR
cord-015021-pol2qm74	7524	11	than	than	IN
cord-015021-pol2qm74	7524	12	half	half	NN
cord-015021-pol2qm74	7524	13	of	of	IN
cord-015021-pol2qm74	7524	14	the	the	DT
cord-015021-pol2qm74	7524	15	estimated	estimate	VBN
cord-015021-pol2qm74	7524	16	value	value	NN
cord-015021-pol2qm74	7524	17	.	.	.
cord-015021-pol2qm74	7525	1	It	-PRON-	PRP
cord-015021-pol2qm74	7525	2	suggests	suggest	VBZ
cord-015021-pol2qm74	7525	3	that	that	IN
cord-015021-pol2qm74	7525	4	low	low	JJ
cord-015021-pol2qm74	7525	5	responsiveness	responsiveness	NN
cord-015021-pol2qm74	7525	6	of	of	IN
cord-015021-pol2qm74	7525	7	G	G	NNP
cord-015021-pol2qm74	7525	8	-	-	HYPH
cord-015021-pol2qm74	7525	9	CSF	CSF	NNP
cord-015021-pol2qm74	7525	10	is	be	VBZ
cord-015021-pol2qm74	7525	11	one	one	CD
cord-015021-pol2qm74	7525	12	of	of	IN
cord-015021-pol2qm74	7525	13	the	the	DT
cord-015021-pol2qm74	7525	14	reason	reason	NN
cord-015021-pol2qm74	7525	15	of	of	IN
cord-015021-pol2qm74	7525	16	immunodeficient	immunodeficient	JJ
cord-015021-pol2qm74	7525	17	state	state	NN
cord-015021-pol2qm74	7525	18	after	after	IN
cord-015021-pol2qm74	7525	19	the	the	DT
cord-015021-pol2qm74	7525	20	major	major	JJ
cord-015021-pol2qm74	7525	21	surgery	surgery	NN
cord-015021-pol2qm74	7525	22	,	,	,
cord-015021-pol2qm74	7525	23	Neutrophils	Neutrophils	NNP
cord-015021-pol2qm74	7525	24	from	from	IN
cord-015021-pol2qm74	7525	25	injured	injure	VBN
cord-015021-pol2qm74	7525	26	patients	patient	NNS
cord-015021-pol2qm74	7525	27	ingest	ingest	VBP
cord-015021-pol2qm74	7525	28	and	and	CC
cord-015021-pol2qm74	7525	29	kill	kill	VB
cord-015021-pol2qm74	7525	30	bacteria	bacteria	NNS
cord-015021-pol2qm74	7525	31	less	less	RBR
cord-015021-pol2qm74	7525	32	efficiently	efficiently	RB
cord-015021-pol2qm74	7525	33	as	as	IN
cord-015021-pol2qm74	7525	34	compared	compare	VBN
cord-015021-pol2qm74	7525	35	to	to	IN
cord-015021-pol2qm74	7525	36	those	those	DT
cord-015021-pol2qm74	7525	37	of	of	IN
cord-015021-pol2qm74	7525	38	healthy	healthy	JJ
cord-015021-pol2qm74	7525	39	individuals	individual	NNS
cord-015021-pol2qm74	7525	40	,	,	,
cord-015021-pol2qm74	7525	41	probably	probably	RB
cord-015021-pol2qm74	7525	42	reflecting	reflect	VBG
cord-015021-pol2qm74	7525	43	the	the	DT
cord-015021-pol2qm74	7525	44	suppression	suppression	NN
cord-015021-pol2qm74	7525	45	in	in	IN
cord-015021-pol2qm74	7525	46	respiratoly	respiratoly	NNP
cord-015021-pol2qm74	7525	47	burst	burst	NN
cord-015021-pol2qm74	7525	48	which	which	WDT
cord-015021-pol2qm74	7525	49	occurs	occur	VBZ
cord-015021-pol2qm74	7525	50	after	after	IN
cord-015021-pol2qm74	7525	51	severe	severe	JJ
cord-015021-pol2qm74	7525	52	trauma	trauma	NN
cord-015021-pol2qm74	7525	53	.	.	.
cord-015021-pol2qm74	7526	1	One	one	CD
cord-015021-pol2qm74	7526	2	of	of	IN
cord-015021-pol2qm74	7526	3	the	the	DT
cord-015021-pol2qm74	7526	4	main	main	JJ
cord-015021-pol2qm74	7526	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	7526	6	of	of	IN
cord-015021-pol2qm74	7526	7	killing	kill	VBG
cord-015021-pol2qm74	7526	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	7526	9	by	by	IN
cord-015021-pol2qm74	7526	10	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7526	11	granulocytes	granulocyte	NNS
cord-015021-pol2qm74	7526	12	is	be	VBZ
cord-015021-pol2qm74	7526	13	production	production	NN
cord-015021-pol2qm74	7526	14	of	of	IN
cord-015021-pol2qm74	7526	15	oxygen	oxygen	NN
cord-015021-pol2qm74	7526	16	radicals	radical	NNS
cord-015021-pol2qm74	7526	17	(	(	-LRB-
cord-015021-pol2qm74	7526	18	respiratory	respiratory	JJ
cord-015021-pol2qm74	7526	19	burst	burst	NN
cord-015021-pol2qm74	7526	20	)	)	-RRB-
cord-015021-pol2qm74	7526	21	.	.	.
cord-015021-pol2qm74	7527	1	Granulocyte	Granulocyte	NNP
cord-015021-pol2qm74	7527	2	colony	colony	NN
cord-015021-pol2qm74	7527	3	-	-	HYPH
cord-015021-pol2qm74	7527	4	stimulating	stimulate	VBG
cord-015021-pol2qm74	7527	5	factor	factor	NN
cord-015021-pol2qm74	7527	6	(	(	-LRB-
cord-015021-pol2qm74	7527	7	G	G	NNP
cord-015021-pol2qm74	7527	8	-	-	HYPH
cord-015021-pol2qm74	7527	9	CSF	CSF	NNP
cord-015021-pol2qm74	7527	10	)	)	-RRB-
cord-015021-pol2qm74	7527	11	,	,	,
cord-015021-pol2qm74	7527	12	a	a	DT
cord-015021-pol2qm74	7527	13	20kilodalton	20kilodalton	CD
cord-015021-pol2qm74	7527	14	cytokine	cytokine	NN
cord-015021-pol2qm74	7527	15	,	,	,
cord-015021-pol2qm74	7527	16	leads	lead	VBZ
cord-015021-pol2qm74	7527	17	to	to	IN
cord-015021-pol2qm74	7527	18	a	a	DT
cord-015021-pol2qm74	7527	19	sustained	sustained	JJ
cord-015021-pol2qm74	7527	20	,	,	,
cord-015021-pol2qm74	7527	21	dose	dose	NN
cord-015021-pol2qm74	7527	22	-	-	HYPH
cord-015021-pol2qm74	7527	23	dependent	dependent	JJ
cord-015021-pol2qm74	7527	24	increase	increase	NN
cord-015021-pol2qm74	7527	25	in	in	IN
cord-015021-pol2qm74	7527	26	circulating	circulate	VBG
cord-015021-pol2qm74	7527	27	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7527	28	.	.	.
cord-015021-pol2qm74	7528	1	Thus	thus	RB
cord-015021-pol2qm74	7528	2	,	,	,
cord-015021-pol2qm74	7528	3	it	-PRON-	PRP
cord-015021-pol2qm74	7528	4	was	be	VBD
cord-015021-pol2qm74	7528	5	investigated	investigate	VBN
cord-015021-pol2qm74	7528	6	whether	whether	IN
cord-015021-pol2qm74	7528	7	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7528	8	(	(	-LRB-
cord-015021-pol2qm74	7528	9	recombinant	recombinant	JJ
cord-015021-pol2qm74	7528	10	human	human	JJ
cord-015021-pol2qm74	7528	11	granulocyte	granulocyte	NN
cord-015021-pol2qm74	7528	12	colony	colony	NN
cord-015021-pol2qm74	7528	13	-	-	HYPH
cord-015021-pol2qm74	7528	14	stimulating	stimulate	VBG
cord-015021-pol2qm74	7528	15	factor	factor	NN
cord-015021-pol2qm74	7528	16	,	,	,
cord-015021-pol2qm74	7528	17	rhG	rhG	NNP
cord-015021-pol2qm74	7528	18	-	-	HYPH
cord-015021-pol2qm74	7528	19	CSF	csf	NN
cord-015021-pol2qm74	7528	20	)	)	-RRB-
cord-015021-pol2qm74	7528	21	therapy	therapy	NN
cord-015021-pol2qm74	7528	22	fits	fit	VBZ
cord-015021-pol2qm74	7528	23	for	for	IN
cord-015021-pol2qm74	7528	24	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	7528	25	of	of	IN
cord-015021-pol2qm74	7528	26	sepsis	sepsis	NN
cord-015021-pol2qm74	7528	27	in	in	IN
cord-015021-pol2qm74	7528	28	postoperative	postoperative	JJ
cord-015021-pol2qm74	7528	29	/	/	SYM
cord-015021-pol2qm74	7528	30	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	7528	31	patients	patient	NNS
cord-015021-pol2qm74	7528	32	,	,	,
cord-015021-pol2qm74	7528	33	and	and	CC
cord-015021-pol2qm74	7528	34	whether	whether	IN
cord-015021-pol2qm74	7528	35	,	,	,
cord-015021-pol2qm74	7528	36	besides	besides	IN
cord-015021-pol2qm74	7528	37	an	an	DT
cord-015021-pol2qm74	7528	38	expected	expect	VBN
cord-015021-pol2qm74	7528	39	increase	increase	NN
cord-015021-pol2qm74	7528	40	in	in	IN
cord-015021-pol2qm74	7528	41	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7528	42	count	count	NN
cord-015021-pol2qm74	7528	43	,	,	,
cord-015021-pol2qm74	7528	44	filgrastim	filgrastim	NNP
cord-015021-pol2qm74	7528	45	would	would	MD
cord-015021-pol2qm74	7528	46	also	also	RB
cord-015021-pol2qm74	7528	47	augment	augment	VB
cord-015021-pol2qm74	7528	48	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7528	49	function	function	NN
cord-015021-pol2qm74	7528	50	.	.	.
cord-015021-pol2qm74	7529	1	MATERIAL	material	NN
cord-015021-pol2qm74	7529	2	AND	and	CC
cord-015021-pol2qm74	7529	3	METHODS	method	NNS
cord-015021-pol2qm74	7529	4	:	:	:
cord-015021-pol2qm74	7530	1	This	this	DT
cord-015021-pol2qm74	7530	2	study	study	NN
cord-015021-pol2qm74	7530	3	was	be	VBD
cord-015021-pol2qm74	7530	4	designed	design	VBN
cord-015021-pol2qm74	7530	5	as	as	IN
cord-015021-pol2qm74	7530	6	an	an	DT
cord-015021-pol2qm74	7530	7	open	open	JJ
cord-015021-pol2qm74	7530	8	label	label	NN
cord-015021-pol2qm74	7530	9	,	,	,
cord-015021-pol2qm74	7530	10	prospective	prospective	JJ
cord-015021-pol2qm74	7530	11	phase	phase	NN
cord-015021-pol2qm74	7530	12	II	ii	CD
cord-015021-pol2qm74	7530	13	study	study	NN
cord-015021-pol2qm74	7530	14	of	of	IN
cord-015021-pol2qm74	7530	15	filgrastim	filgrastim	NNP
cord-015021-pol2qm74	7530	16	and	and	CC
cord-015021-pol2qm74	7530	17	performed	perform	VBN
cord-015021-pol2qm74	7530	18	in	in	IN
cord-015021-pol2qm74	7530	19	a	a	DT
cord-015021-pol2qm74	7530	20	surgical	surgical	JJ
cord-015021-pol2qm74	7530	21	intensive	intensive	JJ
cord-015021-pol2qm74	7530	22	care	care	NN
cord-015021-pol2qm74	7530	23	unit	unit	NN
cord-015021-pol2qm74	7530	24	(	(	-LRB-
cord-015021-pol2qm74	7530	25	SICU	SICU	NNP
cord-015021-pol2qm74	7530	26	)	)	-RRB-
cord-015021-pol2qm74	7530	27	(	(	-LRB-
cord-015021-pol2qm74	7530	28	university	university	NN
cord-015021-pol2qm74	7530	29	hospital	hospital	NN
cord-015021-pol2qm74	7530	30	)	)	-RRB-
cord-015021-pol2qm74	7530	31	.	.	.
cord-015021-pol2qm74	7531	1	10	10	CD
cord-015021-pol2qm74	7531	2	postoperative	postoperative	JJ
cord-015021-pol2qm74	7531	3	/	/	SYM
cord-015021-pol2qm74	7531	4	post	post	JJ
cord-015021-pol2qm74	7531	5	-	-	JJ
cord-015021-pol2qm74	7531	6	traumatic	traumatic	JJ
cord-015021-pol2qm74	7531	7	patients	patient	NNS
cord-015021-pol2qm74	7531	8	with	with	IN
cord-015021-pol2qm74	7531	9	a	a	DT
cord-015021-pol2qm74	7531	10	Therapeutic	Therapeutic	NNP
cord-015021-pol2qm74	7531	11	Intervention	Intervention	NNP
cord-015021-pol2qm74	7531	12	Scoring	Scoring	NNP
cord-015021-pol2qm74	7531	13	System	System	NNP
cord-015021-pol2qm74	7531	14	(	(	-LRB-
cord-015021-pol2qm74	7531	15	TISS	TISS	NNP
cord-015021-pol2qm74	7531	16	)	)	-RRB-
cord-015021-pol2qm74	7531	17	score	score	VBP
cord-015021-pol2qm74	7531	18	greater	great	JJR
cord-015021-pol2qm74	7531	19	than	than	IN
cord-015021-pol2qm74	7531	20	30	30	CD
cord-015021-pol2qm74	7531	21	were	be	VBD
cord-015021-pol2qm74	7531	22	treated	treat	VBN
cord-015021-pol2qm74	7531	23	with	with	IN
cord-015021-pol2qm74	7531	24	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7531	25	(	(	-LRB-
cord-015021-pol2qm74	7531	26	0.5	0.5	CD
cord-015021-pol2qm74	7531	27	-1	-1	CD
cord-015021-pol2qm74	7531	28	l.tg/kg/day	l.tg/kg/day	NNP
cord-015021-pol2qm74	7531	29	)	)	-RRB-
cord-015021-pol2qm74	7531	30	for	for	IN
cord-015021-pol2qm74	7531	31	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	7531	32	of	of	IN
cord-015021-pol2qm74	7531	33	sepsis	sepsis	NN
cord-015021-pol2qm74	7531	34	on	on	IN
cord-015021-pol2qm74	7531	35	7	7	CD
cord-015021-pol2qm74	7531	36	days	day	NNS
cord-015021-pol2qm74	7531	37	or	or	CC
cord-015021-pol2qm74	7531	38	until	until	IN
cord-015021-pol2qm74	7531	39	discharge	discharge	NN
cord-015021-pol2qm74	7531	40	from	from	IN
cord-015021-pol2qm74	7531	41	the	the	DT
cord-015021-pol2qm74	7531	42	SICU	SICU	NNP
cord-015021-pol2qm74	7531	43	.	.	.
cord-015021-pol2qm74	7532	1	Production	production	NN
cord-015021-pol2qm74	7532	2	of	of	IN
cord-015021-pol2qm74	7532	3	oxygen	oxygen	NN
cord-015021-pol2qm74	7532	4	radicals	radical	NNS
cord-015021-pol2qm74	7532	5	can	can	MD
cord-015021-pol2qm74	7532	6	be	be	VB
cord-015021-pol2qm74	7532	7	quantified	quantify	VBN
cord-015021-pol2qm74	7532	8	by	by	IN
cord-015021-pol2qm74	7532	9	analysis	analysis	NN
cord-015021-pol2qm74	7532	10	of	of	IN
cord-015021-pol2qm74	7532	11	FMLP	FMLP	NNP
cord-015021-pol2qm74	7532	12	-	-	HYPH
cord-015021-pol2qm74	7532	13	and	and	CC
cord-015021-pol2qm74	7532	14	zymosan	zymosan	NNP
cord-015021-pol2qm74	7532	15	-	-	HYPH
cord-015021-pol2qm74	7532	16	induced	induce	VBN
cord-015021-pol2qm74	7532	17	chemiluminescence	chemiluminescence	NN
cord-015021-pol2qm74	7532	18	.	.	.
cord-015021-pol2qm74	7533	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	7533	2	oxygen	oxygen	NN
cord-015021-pol2qm74	7533	3	radical	radical	JJ
cord-015021-pol2qm74	7533	4	production	production	NN
cord-015021-pol2qm74	7533	5	was	be	VBD
cord-015021-pol2qm74	7533	6	tested	test	VBN
cord-015021-pol2qm74	7533	7	by	by	IN
cord-015021-pol2qm74	7533	8	FMLP	FMLP	NNP
cord-015021-pol2qm74	7533	9	-	-	HYPH
cord-015021-pol2qm74	7533	10	and	and	CC
cord-015021-pol2qm74	7533	11	zymosan	zymosan	NNP
cord-015021-pol2qm74	7533	12	-	-	HYPH
cord-015021-pol2qm74	7533	13	induced	induce	VBN
cord-015021-pol2qm74	7533	14	chemiluminescence	chemiluminescence	NN
cord-015021-pol2qm74	7533	15	by	by	IN
cord-015021-pol2qm74	7533	16	the	the	DT
cord-015021-pol2qm74	7533	17	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	7533	18	cells	cell	NNS
cord-015021-pol2qm74	7533	19	(	(	-LRB-
cord-015021-pol2qm74	7533	20	PMN	PMN	NNP
cord-015021-pol2qm74	7533	21	)	)	-RRB-
cord-015021-pol2qm74	7533	22	of	of	IN
cord-015021-pol2qm74	7533	23	these	these	DT
cord-015021-pol2qm74	7533	24	patients	patient	NNS
cord-015021-pol2qm74	7533	25	in	in	IN
cord-015021-pol2qm74	7533	26	multiple	multiple	JJ
cord-015021-pol2qm74	7533	27	blood	blood	NN
cord-015021-pol2qm74	7533	28	samples	sample	NNS
cord-015021-pol2qm74	7533	29	over	over	IN
cord-015021-pol2qm74	7533	30	a	a	DT
cord-015021-pol2qm74	7533	31	period	period	NN
cord-015021-pol2qm74	7533	32	of	of	IN
cord-015021-pol2qm74	7533	33	up	up	IN
cord-015021-pol2qm74	7533	34	to	to	TO
cord-015021-pol2qm74	7533	35	14	14	CD
cord-015021-pol2qm74	7533	36	days	day	NNS
cord-015021-pol2qm74	7533	37	.	.	.
cord-015021-pol2qm74	7534	1	RESULTS	result	NNS
cord-015021-pol2qm74	7534	2	:	:	:
cord-015021-pol2qm74	7535	1	None	none	NN
cord-015021-pol2qm74	7535	2	of	of	IN
cord-015021-pol2qm74	7535	3	the	the	DT
cord-015021-pol2qm74	7535	4	patients	patient	NNS
cord-015021-pol2qm74	7535	5	treated	treat	VBN
cord-015021-pol2qm74	7535	6	with	with	IN
cord-015021-pol2qm74	7535	7	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7535	8	for	for	IN
cord-015021-pol2qm74	7535	9	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	7535	10	of	of	IN
cord-015021-pol2qm74	7535	11	sepsis	sepsis	NN
cord-015021-pol2qm74	7535	12	developed	develop	VBD
cord-015021-pol2qm74	7535	13	sepsis	sepsis	NN
cord-015021-pol2qm74	7535	14	.	.	.
cord-015021-pol2qm74	7536	1	In	in	IN
cord-015021-pol2qm74	7536	2	vitro	vitro	FW
cord-015021-pol2qm74	7536	3	FMLP	FMLP	NNP
cord-015021-pol2qm74	7536	4	-	-	HYPH
cord-015021-pol2qm74	7536	5	induced	induce	VBN
cord-015021-pol2qm74	7536	6	(	(	-LRB-
cord-015021-pol2qm74	7536	7	10	10	CD
cord-015021-pol2qm74	7536	8	-7	-7	NNP
cord-015021-pol2qm74	7536	9	reel	reel	NN
cord-015021-pol2qm74	7536	10	/	/	SYM
cord-015021-pol2qm74	7536	11	l	l	NN
cord-015021-pol2qm74	7536	12	)	)	-RRB-
cord-015021-pol2qm74	7536	13	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7536	14	oxygen	oxygen	NN
cord-015021-pol2qm74	7536	15	radical	radical	JJ
cord-015021-pol2qm74	7536	16	production	production	NN
cord-015021-pol2qm74	7536	17	was	be	VBD
cord-015021-pol2qm74	7536	18	significantly	significantly	RB
cord-015021-pol2qm74	7536	19	increased	increase	VBN
cord-015021-pol2qm74	7536	20	under	under	IN
cord-015021-pol2qm74	7536	21	therapy	therapy	NN
cord-015021-pol2qm74	7536	22	with	with	IN
cord-015021-pol2qm74	7536	23	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7536	24	by	by	IN
cord-015021-pol2qm74	7536	25	a	a	DT
cord-015021-pol2qm74	7536	26	maximum	maximum	NN
cord-015021-pol2qm74	7536	27	of	of	IN
cord-015021-pol2qm74	7536	28	797	797	CD
cord-015021-pol2qm74	7536	29	%	%	NN
cord-015021-pol2qm74	7536	30	+	+	CC
cord-015021-pol2qm74	7537	1	-570	-570	NNP
cord-015021-pol2qm74	7537	2	%	%	NN
cord-015021-pol2qm74	7537	3	(	(	-LRB-
cord-015021-pol2qm74	7537	4	217	217	CD
cord-015021-pol2qm74	7537	5	%	%	NN
cord-015021-pol2qm74	7537	6	-1826	-1826	NN
cord-015021-pol2qm74	7537	7	%	%	NN
cord-015021-pol2qm74	7537	8	)	)	-RRB-
cord-015021-pol2qm74	7537	9	compared	compare	VBN
cord-015021-pol2qm74	7537	10	to	to	IN
cord-015021-pol2qm74	7537	11	pretreatment	pretreatment	JJ
cord-015021-pol2qm74	7537	12	values	value	NNS
cord-015021-pol2qm74	7537	13	of	of	IN
cord-015021-pol2qm74	7537	14	100	100	CD
cord-015021-pol2qm74	7537	15	%	%	NN
cord-015021-pol2qm74	7537	16	.	.	.
cord-015021-pol2qm74	7538	1	Tapering	taper	VBG
cord-015021-pol2qm74	7538	2	of	of	IN
cord-015021-pol2qm74	7538	3	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7538	4	resulted	result	VBD
cord-015021-pol2qm74	7538	5	in	in	IN
cord-015021-pol2qm74	7538	6	a	a	DT
cord-015021-pol2qm74	7538	7	reduction	reduction	NN
cord-015021-pol2qm74	7538	8	of	of	IN
cord-015021-pol2qm74	7538	9	FMLP	FMLP	NNP
cord-015021-pol2qm74	7538	10	-	-	HYPH
cord-015021-pol2qm74	7538	11	induced	induce	VBN
cord-015021-pol2qm74	7538	12	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7538	13	oxygen	oxygen	NN
cord-015021-pol2qm74	7538	14	radical	radical	JJ
cord-015021-pol2qm74	7538	15	production	production	NN
cord-015021-pol2qm74	7538	16	within	within	IN
cord-015021-pol2qm74	7538	17	48	48	CD
cord-015021-pol2qm74	7538	18	hours	hour	NNS
cord-015021-pol2qm74	7538	19	.	.	.
cord-015021-pol2qm74	7539	1	In	in	IN
cord-015021-pol2qm74	7539	2	contrast	contrast	NN
cord-015021-pol2qm74	7539	3	,	,	,
cord-015021-pol2qm74	7539	4	zymosan	zymosan	NNP
cord-015021-pol2qm74	7539	5	-	-	HYPH
cord-015021-pol2qm74	7539	6	induced	induce	VBN
cord-015021-pol2qm74	7539	7	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7539	8	oxygen	oxygen	NN
cord-015021-pol2qm74	7539	9	radical	radical	JJ
cord-015021-pol2qm74	7539	10	production	production	NN
cord-015021-pol2qm74	7539	11	was	be	VBD
cord-015021-pol2qm74	7539	12	not	not	RB
cord-015021-pol2qm74	7539	13	affected	affect	VBN
cord-015021-pol2qm74	7539	14	by	by	IN
cord-015021-pol2qm74	7539	15	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7539	16	treatment	treatment	NN
cord-015021-pol2qm74	7539	17	.	.	.
cord-015021-pol2qm74	7540	1	CONCLUSIONS	conclusion	NNS
cord-015021-pol2qm74	7540	2	:	:	:
cord-015021-pol2qm74	7541	1	Besides	besides	IN
cord-015021-pol2qm74	7541	2	its	-PRON-	PRP$
cord-015021-pol2qm74	7541	3	quantitative	quantitative	JJ
cord-015021-pol2qm74	7541	4	effect	effect	NN
cord-015021-pol2qm74	7541	5	on	on	IN
cord-015021-pol2qm74	7541	6	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7541	7	counts	count	NNS
cord-015021-pol2qm74	7541	8	enhanced	enhance	VBN
cord-015021-pol2qm74	7541	9	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7541	10	function	function	NN
cord-015021-pol2qm74	7541	11	,	,	,
cord-015021-pol2qm74	7541	12	documented	document	VBN
cord-015021-pol2qm74	7541	13	here	here	RB
cord-015021-pol2qm74	7541	14	as	as	IN
cord-015021-pol2qm74	7541	15	increased	increase	VBN
cord-015021-pol2qm74	7541	16	FMLP	FMLP	NNP
cord-015021-pol2qm74	7541	17	-	-	HYPH
cord-015021-pol2qm74	7541	18	induced	induce	VBN
cord-015021-pol2qm74	7541	19	oxygen	oxygen	NN
cord-015021-pol2qm74	7541	20	radical	radical	JJ
cord-015021-pol2qm74	7541	21	production	production	NN
cord-015021-pol2qm74	7541	22	,	,	,
cord-015021-pol2qm74	7541	23	may	may	MD
cord-015021-pol2qm74	7541	24	account	account	VB
cord-015021-pol2qm74	7541	25	for	for	IN
cord-015021-pol2qm74	7541	26	the	the	DT
cord-015021-pol2qm74	7541	27	beneficial	beneficial	JJ
cord-015021-pol2qm74	7541	28	effect	effect	NN
cord-015021-pol2qm74	7541	29	of	of	IN
cord-015021-pol2qm74	7541	30	filgrastim	filgrastim	NN
cord-015021-pol2qm74	7541	31	for	for	IN
cord-015021-pol2qm74	7541	32	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	7541	33	of	of	IN
cord-015021-pol2qm74	7541	34	sepsis	sepsis	NN
cord-015021-pol2qm74	7541	35	in	in	IN
cord-015021-pol2qm74	7541	36	posttraumatic	posttraumatic	JJ
cord-015021-pol2qm74	7541	37	/	/	SYM
cord-015021-pol2qm74	7541	38	post	post	JJ
cord-015021-pol2qm74	7541	39	-	-	JJ
cord-015021-pol2qm74	7541	40	operative	operative	JJ
cord-015021-pol2qm74	7541	41	patients	patient	NNS
cord-015021-pol2qm74	7541	42	.	.	.
cord-015021-pol2qm74	7542	1	Granulocyte	Granulocyte	NNP
cord-015021-pol2qm74	7542	2	colony	colony	NN
cord-015021-pol2qm74	7542	3	stimulating	stimulate	VBG
cord-015021-pol2qm74	7542	4	factor	factor	NN
cord-015021-pol2qm74	7542	5	(	(	-LRB-
cord-015021-pol2qm74	7542	6	G	G	NNP
cord-015021-pol2qm74	7542	7	-	-	HYPH
cord-015021-pol2qm74	7542	8	CSF	CSF	NNP
cord-015021-pol2qm74	7542	9	)	)	-RRB-
cord-015021-pol2qm74	7542	10	and	and	CC
cord-015021-pol2qm74	7542	11	granulocytemacrophage	granulocytemacrophage	NNP
cord-015021-pol2qm74	7542	12	colony	colony	NN
cord-015021-pol2qm74	7542	13	stimulating	stimulate	VBG
cord-015021-pol2qm74	7542	14	factor	factor	NN
cord-015021-pol2qm74	7542	15	(	(	-LRB-
cord-015021-pol2qm74	7542	16	GM	GM	NNP
cord-015021-pol2qm74	7542	17	-	-	HYPH
cord-015021-pol2qm74	7542	18	CSF	CSF	NNP
cord-015021-pol2qm74	7542	19	)	)	-RRB-
cord-015021-pol2qm74	7542	20	have	have	VBP
cord-015021-pol2qm74	7542	21	been	be	VBN
cord-015021-pol2qm74	7542	22	recently	recently	RB
cord-015021-pol2qm74	7542	23	introduced	introduce	VBN
cord-015021-pol2qm74	7542	24	in	in	IN
cord-015021-pol2qm74	7542	25	the	the	DT
cord-015021-pol2qm74	7542	26	treatment	treatment	NN
cord-015021-pol2qm74	7542	27	of	of	IN
cord-015021-pol2qm74	7542	28	chemotherapy	chemotherapy	NN
cord-015021-pol2qm74	7542	29	-	-	HYPH
cord-015021-pol2qm74	7542	30	induced	induce	VBN
cord-015021-pol2qm74	7542	31	neutropenia	neutropenia	NN
cord-015021-pol2qm74	7542	32	.	.	.
cord-015021-pol2qm74	7543	1	Effects	effect	NNS
cord-015021-pol2qm74	7543	2	of	of	IN
cord-015021-pol2qm74	7543	3	these	these	DT
cord-015021-pol2qm74	7543	4	CSFs	csf	NNS
cord-015021-pol2qm74	7543	5	on	on	IN
cord-015021-pol2qm74	7543	6	cellular	cellular	JJ
cord-015021-pol2qm74	7543	7	immune	immune	JJ
cord-015021-pol2qm74	7543	8	system	system	NN
cord-015021-pol2qm74	7543	9	were	be	VBD
cord-015021-pol2qm74	7543	10	evaluated	evaluate	VBN
cord-015021-pol2qm74	7543	11	in	in	IN
cord-015021-pol2qm74	7543	12	38	38	CD
cord-015021-pol2qm74	7543	13	neutropenic	neutropenic	JJ
cord-015021-pol2qm74	7543	14	gynecological	gynecological	JJ
cord-015021-pol2qm74	7543	15	cancer	cancer	NN
cord-015021-pol2qm74	7543	16	patients	patient	NNS
cord-015021-pol2qm74	7543	17	during	during	IN
cord-015021-pol2qm74	7543	18	chemotherapy	chemotherapy	NN
cord-015021-pol2qm74	7543	19	.	.	.
cord-015021-pol2qm74	7544	1	G	G	NNP
cord-015021-pol2qm74	7544	2	-	-	HYPH
cord-015021-pol2qm74	7544	3	CSF	CSF	NNP
cord-015021-pol2qm74	7544	4	and	and	CC
cord-015021-pol2qm74	7544	5	GM	GM	NNP
cord-015021-pol2qm74	7544	6	-	-	HYPH
cord-015021-pol2qm74	7544	7	CSF	CSF	NNP
cord-015021-pol2qm74	7544	8	were	be	VBD
cord-015021-pol2qm74	7544	9	equally	equally	RB
cord-015021-pol2qm74	7544	10	able	able	JJ
cord-015021-pol2qm74	7544	11	to	to	TO
cord-015021-pol2qm74	7544	12	induce	induce	VB
cord-015021-pol2qm74	7544	13	a	a	DT
cord-015021-pol2qm74	7544	14	rapid	rapid	JJ
cord-015021-pol2qm74	7544	15	recovery	recovery	NN
cord-015021-pol2qm74	7544	16	of	of	IN
cord-015021-pol2qm74	7544	17	white	white	JJ
cord-015021-pol2qm74	7544	18	cell	cell	NN
cord-015021-pol2qm74	7544	19	count	count	NN
cord-015021-pol2qm74	7544	20	within	within	IN
cord-015021-pol2qm74	7544	21	one	one	CD
cord-015021-pol2qm74	7544	22	or	or	CC
cord-015021-pol2qm74	7544	23	two	two	CD
cord-015021-pol2qm74	7544	24	days	day	NNS
cord-015021-pol2qm74	7544	25	.	.	.
cord-015021-pol2qm74	7545	1	G	G	NNP
cord-015021-pol2qm74	7545	2	-	-	HYPH
cord-015021-pol2qm74	7545	3	CSF	CSF	NNP
cord-015021-pol2qm74	7545	4	treatment	treatment	NN
cord-015021-pol2qm74	7545	5	resulted	result	VBD
cord-015021-pol2qm74	7545	6	in	in	IN
cord-015021-pol2qm74	7545	7	a	a	DT
cord-015021-pol2qm74	7545	8	significantly	significantly	RB
cord-015021-pol2qm74	7545	9	higher	high	JJR
cord-015021-pol2qm74	7545	10	concentration	concentration	NN
cord-015021-pol2qm74	7545	11	of	of	IN
cord-015021-pol2qm74	7545	12	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7545	13	measured	measure	VBN
cord-015021-pol2qm74	7545	14	in	in	IN
cord-015021-pol2qm74	7545	15	the	the	DT
cord-015021-pol2qm74	7545	16	peripheral	peripheral	JJ
cord-015021-pol2qm74	7545	17	blood	blood	NN
cord-015021-pol2qm74	7545	18	although	although	IN
cord-015021-pol2qm74	7545	19	by	by	IN
cord-015021-pol2qm74	7545	20	GM	GM	NNP
cord-015021-pol2qm74	7545	21	-	-	HYPH
cord-015021-pol2qm74	7545	22	CSF	CSF	NNP
cord-015021-pol2qm74	7545	23	a	a	DT
cord-015021-pol2qm74	7545	24	sufficient	sufficient	JJ
cord-015021-pol2qm74	7545	25	effect	effect	NN
cord-015021-pol2qm74	7545	26	was	be	VBD
cord-015021-pol2qm74	7545	27	achieved	achieve	VBN
cord-015021-pol2qm74	7545	28	(	(	-LRB-
cord-015021-pol2qm74	7545	29	p<0.05	p<0.05	CD
cord-015021-pol2qm74	7545	30	)	)	-RRB-
cord-015021-pol2qm74	7545	31	.	.	.
cord-015021-pol2qm74	7546	1	Before	before	IN
cord-015021-pol2qm74	7546	2	initiation	initiation	NN
cord-015021-pol2qm74	7546	3	of	of	IN
cord-015021-pol2qm74	7546	4	CSF	CSF	NNP
cord-015021-pol2qm74	7546	5	treatment	treatment	NN
cord-015021-pol2qm74	7546	6	urinary	urinary	JJ
cord-015021-pol2qm74	7546	7	neopterin	neopterin	NNP
cord-015021-pol2qm74	7546	8	was	be	VBD
cord-015021-pol2qm74	7546	9	similar	similar	JJ
cord-015021-pol2qm74	7546	10	in	in	IN
cord-015021-pol2qm74	7546	11	both	both	DT
cord-015021-pol2qm74	7546	12	groups	group	NNS
cord-015021-pol2qm74	7546	13	of	of	IN
cord-015021-pol2qm74	7546	14	patients	patient	NNS
cord-015021-pol2qm74	7546	15	(	(	-LRB-
cord-015021-pol2qm74	7546	16	283+/-38	283+/-38	CD
cord-015021-pol2qm74	7546	17	and	and	CC
cord-015021-pol2qm74	7546	18	267+/-40	267+/-40	CD
cord-015021-pol2qm74	7546	19	lamol	lamol	JJ
cord-015021-pol2qm74	7546	20	/	/	SYM
cord-015021-pol2qm74	7546	21	mol	mol	NN
cord-015021-pol2qm74	7546	22	creatinine	creatinine	NN
cord-015021-pol2qm74	7546	23	for	for	IN
cord-015021-pol2qm74	7546	24	GM	GM	NNP
cord-015021-pol2qm74	7546	25	-	-	HYPH
cord-015021-pol2qm74	7546	26	CSF	CSF	NNP
cord-015021-pol2qm74	7546	27	and	and	CC
cord-015021-pol2qm74	7546	28	G	G	NNP
cord-015021-pol2qm74	7546	29	-	-	HYPH
cord-015021-pol2qm74	7546	30	CSF	CSF	NNP
cord-015021-pol2qm74	7546	31	respectively	respectively	RB
cord-015021-pol2qm74	7546	32	expressed	express	VBD
cord-015021-pol2qm74	7546	33	as	as	IN
cord-015021-pol2qm74	7546	34	mean	mean	NN
cord-015021-pol2qm74	7546	35	+	+	CC
cord-015021-pol2qm74	7546	36	/-one	/-one	CD
cord-015021-pol2qm74	7546	37	SD	sd	NN
cord-015021-pol2qm74	7546	38	)	)	-RRB-
cord-015021-pol2qm74	7546	39	.	.	.
cord-015021-pol2qm74	7547	1	In	in	IN
cord-015021-pol2qm74	7547	2	G	G	NNP
cord-015021-pol2qm74	7547	3	-	-	HYPH
cord-015021-pol2qm74	7547	4	CSF	csf	NN
cord-015021-pol2qm74	7547	5	treated	treat	VBN
cord-015021-pol2qm74	7547	6	patient	patient	NN
cord-015021-pol2qm74	7547	7	only	only	RB
cord-015021-pol2qm74	7547	8	a	a	DT
cord-015021-pol2qm74	7547	9	marginal	marginal	JJ
cord-015021-pol2qm74	7547	10	induction	induction	NN
cord-015021-pol2qm74	7547	11	of	of	IN
cord-015021-pol2qm74	7547	12	neopterin	neopterin	NNP
cord-015021-pol2qm74	7547	13	was	be	VBD
cord-015021-pol2qm74	7547	14	observed	observe	VBN
cord-015021-pol2qm74	7547	15	.	.	.
cord-015021-pol2qm74	7548	1	On	on	IN
cord-015021-pol2qm74	7548	2	day	day	NN
cord-015021-pol2qm74	7548	3	4	4	CD
cord-015021-pol2qm74	7548	4	the	the	DT
cord-015021-pol2qm74	7548	5	mean	mean	JJ
cord-015021-pol2qm74	7548	6	value	value	NN
cord-015021-pol2qm74	7548	7	was	be	VBD
cord-015021-pol2qm74	7548	8	about	about	RB
cord-015021-pol2qm74	7548	9	40	40	CD
cord-015021-pol2qm74	7548	10	%	%	NN
cord-015021-pol2qm74	7548	11	above	above	IN
cord-015021-pol2qm74	7548	12	the	the	DT
cord-015021-pol2qm74	7548	13	basal	basal	NN
cord-015021-pol2qm74	7548	14	level	level	NN
cord-015021-pol2qm74	7548	15	(	(	-LRB-
cord-015021-pol2qm74	7548	16	p<0.05	p<0.05	CD
cord-015021-pol2qm74	7548	17	)	)	-RRB-
cord-015021-pol2qm74	7548	18	.	.	.
cord-015021-pol2qm74	7549	1	On	on	IN
cord-015021-pol2qm74	7549	2	the	the	DT
cord-015021-pol2qm74	7549	3	other	other	JJ
cord-015021-pol2qm74	7549	4	hand	hand	NN
cord-015021-pol2qm74	7549	5	GM	GM	NNP
cord-015021-pol2qm74	7549	6	-	-	HYPH
cord-015021-pol2qm74	7549	7	CSF	CSF	NNP
cord-015021-pol2qm74	7549	8	treated	treat	VBD
cord-015021-pol2qm74	7549	9	patients	patient	NNS
cord-015021-pol2qm74	7549	10	were	be	VBD
cord-015021-pol2qm74	7549	11	characterized	characterize	VBN
cord-015021-pol2qm74	7549	12	by	by	IN
cord-015021-pol2qm74	7549	13	a	a	DT
cord-015021-pol2qm74	7549	14	pronounced	pronounced	JJ
cord-015021-pol2qm74	7549	15	increase	increase	NN
cord-015021-pol2qm74	7549	16	in	in	IN
cord-015021-pol2qm74	7549	17	urinary	urinary	JJ
cord-015021-pol2qm74	7549	18	neopterin	neopterin	JJ
cord-015021-pol2qm74	7549	19	levels	level	NNS
cord-015021-pol2qm74	7549	20	.	.	.
cord-015021-pol2qm74	7550	1	In	in	IN
cord-015021-pol2qm74	7550	2	comparison	comparison	NN
cord-015021-pol2qm74	7550	3	with	with	IN
cord-015021-pol2qm74	7550	4	the	the	DT
cord-015021-pol2qm74	7550	5	basal	basal	NN
cord-015021-pol2qm74	7550	6	level	level	NN
cord-015021-pol2qm74	7550	7	a	a	DT
cord-015021-pol2qm74	7550	8	more	more	JJR
cord-015021-pol2qm74	7550	9	than	than	IN
cord-015021-pol2qm74	7550	10	2	2	CD
cord-015021-pol2qm74	7550	11	fold	fold	NN
cord-015021-pol2qm74	7550	12	induction	induction	NN
cord-015021-pol2qm74	7550	13	was	be	VBD
cord-015021-pol2qm74	7550	14	noted	note	VBN
cord-015021-pol2qm74	7550	15	and	and	CC
cord-015021-pol2qm74	7550	16	the	the	DT
cord-015021-pol2qm74	7550	17	difference	difference	NN
cord-015021-pol2qm74	7550	18	between	between	IN
cord-015021-pol2qm74	7550	19	G	G	NNP
cord-015021-pol2qm74	7550	20	-	-	HYPH
cord-015021-pol2qm74	7550	21	CSF	CSF	NNP
cord-015021-pol2qm74	7550	22	and	and	CC
cord-015021-pol2qm74	7550	23	GM	GM	NNP
cord-015021-pol2qm74	7550	24	-	-	HYPH
cord-015021-pol2qm74	7550	25	CSF	CSF	NNP
cord-015021-pol2qm74	7550	26	was	be	VBD
cord-015021-pol2qm74	7550	27	highly	highly	RB
cord-015021-pol2qm74	7550	28	significant	significant	JJ
cord-015021-pol2qm74	7550	29	(	(	-LRB-
cord-015021-pol2qm74	7550	30	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	7550	31	)	)	-RRB-
cord-015021-pol2qm74	7550	32	.	.	.
cord-015021-pol2qm74	7551	1	This	this	DT
cord-015021-pol2qm74	7551	2	effect	effect	NN
cord-015021-pol2qm74	7551	3	was	be	VBD
cord-015021-pol2qm74	7551	4	confirmed	confirm	VBN
cord-015021-pol2qm74	7551	5	in	in	IN
cord-015021-pol2qm74	7551	6	vitro	vitro	FW
cord-015021-pol2qm74	7551	7	by	by	IN
cord-015021-pol2qm74	7551	8	investigating	investigate	VBG
cord-015021-pol2qm74	7551	9	the	the	DT
cord-015021-pol2qm74	7551	10	effects	effect	NNS
cord-015021-pol2qm74	7551	11	of	of	IN
cord-015021-pol2qm74	7551	12	these	these	DT
cord-015021-pol2qm74	7551	13	CSFs	csf	NNS
cord-015021-pol2qm74	7551	14	on	on	IN
cord-015021-pol2qm74	7551	15	interferon	interferon	NN
cord-015021-pol2qm74	7551	16	-	-	HYPH
cord-015021-pol2qm74	7551	17	gamma	gamma	NN
cord-015021-pol2qm74	7551	18	mediated	mediate	VBN
cord-015021-pol2qm74	7551	19	pathways	pathway	NNS
cord-015021-pol2qm74	7551	20	in	in	IN
cord-015021-pol2qm74	7551	21	THP-1	THP-1	NNP
cord-015021-pol2qm74	7551	22	human	human	JJ
cord-015021-pol2qm74	7551	23	myelomonocytic	myelomonocytic	NN
cord-015021-pol2qm74	7551	24	cells	cell	NNS
cord-015021-pol2qm74	7551	25	.	.	.
cord-015021-pol2qm74	7552	1	Results	result	NNS
cord-015021-pol2qm74	7552	2	suggest	suggest	VBP
cord-015021-pol2qm74	7552	3	activation	activation	NN
cord-015021-pol2qm74	7552	4	of	of	IN
cord-015021-pol2qm74	7552	5	immune	immune	JJ
cord-015021-pol2qm74	7552	6	effector	effector	NN
cord-015021-pol2qm74	7552	7	cells	cell	NNS
cord-015021-pol2qm74	7552	8	by	by	IN
cord-015021-pol2qm74	7552	9	GM	GM	NNP
cord-015021-pol2qm74	7552	10	-	-	HYPH
cord-015021-pol2qm74	7552	11	CSF	CSF	NNP
cord-015021-pol2qm74	7552	12	which	which	WDT
cord-015021-pol2qm74	7552	13	may	may	MD
cord-015021-pol2qm74	7552	14	help	help	VB
cord-015021-pol2qm74	7552	15	the	the	DT
cord-015021-pol2qm74	7552	16	organism	organism	NN
cord-015021-pol2qm74	7552	17	to	to	TO
cord-015021-pol2qm74	7552	18	overcome	overcome	VB
cord-015021-pol2qm74	7552	19	infections	infection	NNS
cord-015021-pol2qm74	7552	20	.	.	.
cord-015021-pol2qm74	7553	1	However	however	RB
cord-015021-pol2qm74	7553	2	,	,	,
cord-015021-pol2qm74	7553	3	activated	activate	VBN
cord-015021-pol2qm74	7553	4	macrophages	macrophage	NNS
cord-015021-pol2qm74	7553	5	produce	produce	VBP
cord-015021-pol2qm74	7553	6	several	several	JJ
cord-015021-pol2qm74	7553	7	growth	growth	NN
cord-015021-pol2qm74	7553	8	factors	factor	NNS
cord-015021-pol2qm74	7553	9	which	which	WDT
cord-015021-pol2qm74	7553	10	may	may	MD
cord-015021-pol2qm74	7553	11	increase	increase	VB
cord-015021-pol2qm74	7553	12	malignant	malignant	JJ
cord-015021-pol2qm74	7553	13	proliferation	proliferation	NN
cord-015021-pol2qm74	7553	14	,	,	,
cord-015021-pol2qm74	7553	15	and	and	CC
cord-015021-pol2qm74	7553	16	augmented	augment	VBN
cord-015021-pol2qm74	7553	17	neopterin	neopterin	JJ
cord-015021-pol2qm74	7553	18	production	production	NN
cord-015021-pol2qm74	7553	19	as	as	IN
cord-015021-pol2qm74	7553	20	sign	sign	NN
cord-015021-pol2qm74	7553	21	of	of	IN
cord-015021-pol2qm74	7553	22	macrophage	macrophage	NN
cord-015021-pol2qm74	7553	23	activation	activation	NN
cord-015021-pol2qm74	7553	24	has	have	VBZ
cord-015021-pol2qm74	7553	25	also	also	RB
cord-015021-pol2qm74	7553	26	been	be	VBN
cord-015021-pol2qm74	7553	27	associated	associate	VBN
cord-015021-pol2qm74	7553	28	with	with	IN
cord-015021-pol2qm74	7553	29	poor	poor	JJ
cord-015021-pol2qm74	7553	30	prognosis	prognosis	NN
cord-015021-pol2qm74	7553	31	m	m	CD
cord-015021-pol2qm74	7553	32	several	several	JJ
cord-015021-pol2qm74	7553	33	malignancies	malignancy	NNS
cord-015021-pol2qm74	7553	34	.	.	.
cord-015021-pol2qm74	7554	1	More	More	JJR
cord-015021-pol2qm74	7554	2	data	datum	NNS
cord-015021-pol2qm74	7554	3	are	be	VBP
cord-015021-pol2qm74	7554	4	therefore	therefore	RB
cord-015021-pol2qm74	7554	5	necessary	necessary	JJ
cord-015021-pol2qm74	7554	6	to	to	TO
cord-015021-pol2qm74	7554	7	clarify	clarify	VB
cord-015021-pol2qm74	7554	8	whether	whether	IN
cord-015021-pol2qm74	7554	9	CSF	CSF	NNP
cord-015021-pol2qm74	7554	10	mediated	mediate	VBD
cord-015021-pol2qm74	7554	11	immune	immune	JJ
cord-015021-pol2qm74	7554	12	activation	activation	NN
cord-015021-pol2qm74	7554	13	is	be	VBZ
cord-015021-pol2qm74	7554	14	beneficial	beneficial	JJ
cord-015021-pol2qm74	7554	15	or	or	CC
cord-015021-pol2qm74	7554	16	deleterious	deleterious	JJ
cord-015021-pol2qm74	7554	17	for	for	IN
cord-015021-pol2qm74	7554	18	cancer	cancer	NN
cord-015021-pol2qm74	7554	19	patients	patient	NNS
cord-015021-pol2qm74	7554	20	but	but	CC
cord-015021-pol2qm74	7554	21	considering	consider	VBG
cord-015021-pol2qm74	7554	22	our	-PRON-	PRP$
cord-015021-pol2qm74	7554	23	results	result	NNS
cord-015021-pol2qm74	7554	24	caution	caution	NN
cord-015021-pol2qm74	7554	25	in	in	IN
cord-015021-pol2qm74	7554	26	applying	apply	VBG
cord-015021-pol2qm74	7554	27	CSFs	CSFs	NNP
cord-015021-pol2qm74	7554	28	in	in	IN
cord-015021-pol2qm74	7554	29	oncology	oncology	NN
cord-015021-pol2qm74	7554	30	seems	seem	VBZ
cord-015021-pol2qm74	7554	31	advised	advise	VBN
cord-015021-pol2qm74	7554	32	.	.	.
cord-015021-pol2qm74	7555	1	From	from	IN
cord-015021-pol2qm74	7555	2	a	a	DT
cord-015021-pol2qm74	7555	3	historical	historical	JJ
cord-015021-pol2qm74	7555	4	perspective	perspective	NN
cord-015021-pol2qm74	7555	5	,	,	,
cord-015021-pol2qm74	7555	6	the	the	DT
cord-015021-pol2qm74	7555	7	development	development	NN
cord-015021-pol2qm74	7555	8	of	of	IN
cord-015021-pol2qm74	7555	9	humoral	humoral	JJ
cord-015021-pol2qm74	7555	10	immunity	immunity	NN
cord-015021-pol2qm74	7555	11	to	to	IN
cord-015021-pol2qm74	7555	12	bacterial	bacterial	JJ
cord-015021-pol2qm74	7555	13	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7555	14	has	have	VBZ
cord-015021-pol2qm74	7555	15	assumed	assume	VBN
cord-015021-pol2qm74	7555	16	a	a	DT
cord-015021-pol2qm74	7555	17	prominent	prominent	JJ
cord-015021-pol2qm74	7555	18	position	position	NN
cord-015021-pol2qm74	7555	19	in	in	IN
cord-015021-pol2qm74	7555	20	the	the	DT
cord-015021-pol2qm74	7555	21	spectrum	spectrum	NN
cord-015021-pol2qm74	7555	22	of	of	IN
cord-015021-pol2qm74	7555	23	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7555	24	approaches	approach	NNS
cord-015021-pol2qm74	7555	25	which	which	WDT
cord-015021-pol2qm74	7555	26	have	have	VBP
cord-015021-pol2qm74	7555	27	been	be	VBN
cord-015021-pol2qm74	7555	28	explored	explore	VBN
cord-015021-pol2qm74	7555	29	for	for	IN
cord-015021-pol2qm74	7555	30	the	the	DT
cord-015021-pol2qm74	7555	31	treatment	treatment	NN
cord-015021-pol2qm74	7555	32	of	of	IN
cord-015021-pol2qm74	7555	33	Gram	Gram	NNP
cord-015021-pol2qm74	7555	34	negative	negative	JJ
cord-015021-pol2qm74	7555	35	septic	septic	JJ
cord-015021-pol2qm74	7555	36	shock	shock	NN
cord-015021-pol2qm74	7555	37	.	.	.
cord-015021-pol2qm74	7556	1	Predicated	predicate	VBN
cord-015021-pol2qm74	7556	2	upon	upon	IN
cord-015021-pol2qm74	7556	3	the	the	DT
cord-015021-pol2qm74	7556	4	fact	fact	NN
cord-015021-pol2qm74	7556	5	that	that	IN
cord-015021-pol2qm74	7556	6	rough	rough	JJ
cord-015021-pol2qm74	7556	7	strains	strain	NNS
cord-015021-pol2qm74	7556	8	of	of	IN
cord-015021-pol2qm74	7556	9	bacteria	bacteria	NNS
cord-015021-pol2qm74	7556	10	manifest	manifest	VBP
cord-015021-pol2qm74	7556	11	LPS	LPS	NNP
cord-015021-pol2qm74	7556	12	containing	contain	VBG
cord-015021-pol2qm74	7556	13	exclusively	exclusively	RB
cord-015021-pol2qm74	7556	14	conserved	conserve	VBN
cord-015021-pol2qm74	7556	15	structural	structural	JJ
cord-015021-pol2qm74	7556	16	features	feature	NNS
cord-015021-pol2qm74	7556	17	common	common	JJ
cord-015021-pol2qm74	7556	18	to	to	IN
cord-015021-pol2qm74	7556	19	LPS	lp	NNS
cord-015021-pol2qm74	7556	20	from	from	IN
cord-015021-pol2qm74	7556	21	all	all	DT
cord-015021-pol2qm74	7556	22	Gram	Gram	NNP
cord-015021-pol2qm74	7556	23	negatives	negative	NNS
cord-015021-pol2qm74	7556	24	,	,	,
cord-015021-pol2qm74	7556	25	specific	specific	JJ
cord-015021-pol2qm74	7556	26	antibodies	antibody	NNS
cord-015021-pol2qm74	7556	27	were	be	VBD
cord-015021-pol2qm74	7556	28	elicited	elicit	VBN
cord-015021-pol2qm74	7556	29	which	which	WDT
cord-015021-pol2qm74	7556	30	conveyed	convey	VBD
cord-015021-pol2qm74	7556	31	cross	cross	JJ
cord-015021-pol2qm74	7556	32	protective	protective	JJ
cord-015021-pol2qm74	7556	33	immunity	immunity	NN
cord-015021-pol2qm74	7556	34	in	in	IN
cord-015021-pol2qm74	7556	35	experimental	experimental	JJ
cord-015021-pol2qm74	7556	36	models	model	NNS
cord-015021-pol2qm74	7556	37	of	of	IN
cord-015021-pol2qm74	7556	38	bacteremia	bacteremia	NN
cord-015021-pol2qm74	7556	39	and	and	CC
cord-015021-pol2qm74	7556	40	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7556	41	.	.	.
cord-015021-pol2qm74	7557	1	Such	such	JJ
cord-015021-pol2qm74	7557	2	studies	study	NNS
cord-015021-pol2qm74	7557	3	culminated	culminate	VBD
cord-015021-pol2qm74	7557	4	in	in	IN
cord-015021-pol2qm74	7557	5	a	a	DT
cord-015021-pol2qm74	7557	6	well	well	RB
cord-015021-pol2qm74	7557	7	-	-	HYPH
cord-015021-pol2qm74	7557	8	conducted	conduct	VBN
cord-015021-pol2qm74	7557	9	,	,	,
cord-015021-pol2qm74	7557	10	randomized	randomized	JJ
cord-015021-pol2qm74	7557	11	,	,	,
cord-015021-pol2qm74	7557	12	double	double	JJ
cord-015021-pol2qm74	7557	13	-	-	HYPH
cord-015021-pol2qm74	7557	14	blind	blind	JJ
cord-015021-pol2qm74	7557	15	placebo	placebo	NN
cord-015021-pol2qm74	7557	16	-	-	HYPH
cord-015021-pol2qm74	7557	17	controlled	control	VBN
cord-015021-pol2qm74	7557	18	clinical	clinical	JJ
cord-015021-pol2qm74	7557	19	trial	trial	NN
cord-015021-pol2qm74	7557	20	using	use	VBG
cord-015021-pol2qm74	7557	21	passively	passively	RB
cord-015021-pol2qm74	7557	22	administered	administer	VBN
cord-015021-pol2qm74	7557	23	human	human	JJ
cord-015021-pol2qm74	7557	24	polyclonal	polyclonal	JJ
cord-015021-pol2qm74	7557	25	antiserum	antiserum	NN
cord-015021-pol2qm74	7557	26	to	to	TO
cord-015021-pol2qm74	7557	27	treat	treat	VB
cord-015021-pol2qm74	7557	28	patients	patient	NNS
cord-015021-pol2qm74	7557	29	with	with	IN
cord-015021-pol2qm74	7557	30	suspected	suspect	VBN
cord-015021-pol2qm74	7557	31	Gram	Gram	NNP
cord-015021-pol2qm74	7557	32	negative	negative	JJ
cord-015021-pol2qm74	7557	33	sepsis	sepsis	NN
cord-015021-pol2qm74	7557	34	.	.	.
cord-015021-pol2qm74	7558	1	The	the	DT
cord-015021-pol2qm74	7558	2	efficacy	efficacy	NN
cord-015021-pol2qm74	7558	3	of	of	IN
cord-015021-pol2qm74	7558	4	treatment	treatment	NN
cord-015021-pol2qm74	7558	5	established	establish	VBN
cord-015021-pol2qm74	7558	6	in	in	IN
cord-015021-pol2qm74	7558	7	that	that	DT
cord-015021-pol2qm74	7558	8	trial	trial	NN
cord-015021-pol2qm74	7558	9	spurred	spur	VBD
cord-015021-pol2qm74	7558	10	efforts	effort	NNS
cord-015021-pol2qm74	7558	11	to	to	TO
cord-015021-pol2qm74	7558	12	develop	develop	VB
cord-015021-pol2qm74	7558	13	monoclonai	monoclonai	JJ
cord-015021-pol2qm74	7558	14	reagents	reagent	NNS
cord-015021-pol2qm74	7558	15	which	which	WDT
cord-015021-pol2qm74	7558	16	,	,	,
cord-015021-pol2qm74	7558	17	to	to	IN
cord-015021-pol2qm74	7558	18	date	date	NN
cord-015021-pol2qm74	7558	19	,	,	,
cord-015021-pol2qm74	7558	20	have	have	VBP
cord-015021-pol2qm74	7558	21	not	not	RB
cord-015021-pol2qm74	7558	22	been	be	VBN
cord-015021-pol2qm74	7558	23	uniformly	uniformly	RB
cord-015021-pol2qm74	7558	24	successful	successful	JJ
cord-015021-pol2qm74	7558	25	in	in	IN
cord-015021-pol2qm74	7558	26	reproducing	reproduce	VBG
cord-015021-pol2qm74	7558	27	those	those	DT
cord-015021-pol2qm74	7558	28	earlier	early	JJR
cord-015021-pol2qm74	7558	29	studies	study	NNS
cord-015021-pol2qm74	7558	30	with	with	IN
cord-015021-pol2qm74	7558	31	polyclonai	polyclonai	NNP
cord-015021-pol2qm74	7558	32	antibodies	antibody	NNS
cord-015021-pol2qm74	7558	33	.	.	.
cord-015021-pol2qm74	7559	1	Nevertheless	nevertheless	RB
cord-015021-pol2qm74	7559	2	,	,	,
cord-015021-pol2qm74	7559	3	the	the	DT
cord-015021-pol2qm74	7559	4	numerous	numerous	JJ
cord-015021-pol2qm74	7559	5	successes	success	NNS
cord-015021-pol2qm74	7559	6	which	which	WDT
cord-015021-pol2qm74	7559	7	have	have	VBP
cord-015021-pol2qm74	7559	8	been	be	VBN
cord-015021-pol2qm74	7559	9	documented	document	VBN
cord-015021-pol2qm74	7559	10	in	in	IN
cord-015021-pol2qm74	7559	11	experimental	experimental	JJ
cord-015021-pol2qm74	7559	12	models	model	NNS
cord-015021-pol2qm74	7559	13	of	of	IN
cord-015021-pol2qm74	7559	14	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7559	15	continue	continue	VBP
cord-015021-pol2qm74	7559	16	to	to	TO
cord-015021-pol2qm74	7559	17	foster	foster	VB
cord-015021-pol2qm74	7559	18	promise	promise	NN
cord-015021-pol2qm74	7559	19	for	for	IN
cord-015021-pol2qm74	7559	20	this	this	DT
cord-015021-pol2qm74	7559	21	immunotherapeutie	immunotherapeutie	NN
cord-015021-pol2qm74	7559	22	approach	approach	NN
cord-015021-pol2qm74	7559	23	.	.	.
cord-015021-pol2qm74	7560	1	Several	several	JJ
cord-015021-pol2qm74	7560	2	recent	recent	JJ
cord-015021-pol2qm74	7560	3	studies	study	NNS
cord-015021-pol2qm74	7560	4	with	with	IN
cord-015021-pol2qm74	7560	5	human	human	JJ
cord-015021-pol2qm74	7560	6	polyclonalimrnunoglobulin	polyclonalimrnunoglobulin	NNP
cord-015021-pol2qm74	7560	7	preparations	preparation	NNS
cord-015021-pol2qm74	7560	8	containing	contain	VBG
cord-015021-pol2qm74	7560	9	antibodies	antibody	NNS
cord-015021-pol2qm74	7560	10	reactive	reactive	JJ
cord-015021-pol2qm74	7560	11	with	with	IN
cord-015021-pol2qm74	7560	12	LPS	LPS	NNP
cord-015021-pol2qm74	7560	13	and	and	CC
cord-015021-pol2qm74	7560	14	lipid	lipid	NN
cord-015021-pol2qm74	7560	15	A	a	DT
cord-015021-pol2qm74	7560	16	have	have	VBP
cord-015021-pol2qm74	7560	17	yielded	yield	VBN
cord-015021-pol2qm74	7560	18	promising	promising	JJ
cord-015021-pol2qm74	7560	19	results	result	NNS
cord-015021-pol2qm74	7560	20	in	in	IN
cord-015021-pol2qm74	7560	21	treatment	treatment	NN
cord-015021-pol2qm74	7560	22	of	of	IN
cord-015021-pol2qm74	7560	23	patients	patient	NNS
cord-015021-pol2qm74	7560	24	with	with	IN
cord-015021-pol2qm74	7560	25	sepsis	sepsis	NN
cord-015021-pol2qm74	7560	26	.	.	.
cord-015021-pol2qm74	7561	1	In	in	IN
cord-015021-pol2qm74	7561	2	addition	addition	NN
cord-015021-pol2qm74	7561	3	,	,	,
cord-015021-pol2qm74	7561	4	the	the	DT
cord-015021-pol2qm74	7561	5	recent	recent	JJ
cord-015021-pol2qm74	7561	6	development	development	NN
cord-015021-pol2qm74	7561	7	of	of	IN
cord-015021-pol2qm74	7561	8	an	an	DT
cord-015021-pol2qm74	7561	9	antiidiotypic	antiidiotypic	JJ
cord-015021-pol2qm74	7561	10	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7561	11	antibody	antibody	NN
cord-015021-pol2qm74	7561	12	which	which	WDT
cord-015021-pol2qm74	7561	13	reflects	reflect	VBZ
cord-015021-pol2qm74	7561	14	an	an	DT
cord-015021-pol2qm74	7561	15	internal	internal	JJ
cord-015021-pol2qm74	7561	16	image	image	NN
cord-015021-pol2qm74	7561	17	of	of	IN
cord-015021-pol2qm74	7561	18	a	a	DT
cord-015021-pol2qm74	7561	19	kDO	kdo	XX
cord-015021-pol2qm74	7561	20	specific	specific	JJ
cord-015021-pol2qm74	7561	21	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7561	22	antibody	antibody	NN
cord-015021-pol2qm74	7561	23	has	have	VBZ
cord-015021-pol2qm74	7561	24	provided	provide	VBN
cord-015021-pol2qm74	7561	25	an	an	DT
cord-015021-pol2qm74	7561	26	alternative	alternative	JJ
cord-015021-pol2qm74	7561	27	experimental	experimental	JJ
cord-015021-pol2qm74	7561	28	approach	approach	NN
cord-015021-pol2qm74	7561	29	to	to	TO
cord-015021-pol2qm74	7561	30	generate	generate	VB
cord-015021-pol2qm74	7561	31	anti	anti	JJ
cord-015021-pol2qm74	7561	32	-	-	JJ
cord-015021-pol2qm74	7561	33	LPS	lps	JJ
cord-015021-pol2qm74	7561	34	antibody	antibody	NN
cord-015021-pol2qm74	7561	35	.	.	.
cord-015021-pol2qm74	7562	1	Immunization	immunization	NN
cord-015021-pol2qm74	7562	2	of	of	IN
cord-015021-pol2qm74	7562	3	mice	mouse	NNS
cord-015021-pol2qm74	7562	4	with	with	IN
cord-015021-pol2qm74	7562	5	the	the	DT
cord-015021-pol2qm74	7562	6	antiidiotype	antiidiotype	NNP
cord-015021-pol2qm74	7562	7	provides	provide	VBZ
cord-015021-pol2qm74	7562	8	significant	significant	JJ
cord-015021-pol2qm74	7562	9	protection	protection	NN
cord-015021-pol2qm74	7562	10	against	against	IN
cord-015021-pol2qm74	7562	11	subsequent	subsequent	JJ
cord-015021-pol2qm74	7562	12	LPS	LPS	NNP
cord-015021-pol2qm74	7562	13	lethality	lethality	NN
cord-015021-pol2qm74	7562	14	consistent	consistent	JJ
cord-015021-pol2qm74	7562	15	with	with	IN
cord-015021-pol2qm74	7562	16	the	the	DT
cord-015021-pol2qm74	7562	17	development	development	NN
cord-015021-pol2qm74	7562	18	of	of	IN
cord-015021-pol2qm74	7562	19	circulating	circulate	VBG
cord-015021-pol2qm74	7562	20	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	7562	21	specific	specific	JJ
cord-015021-pol2qm74	7562	22	for	for	IN
cord-015021-pol2qm74	7562	23	LPS	lp	NNS
cord-015021-pol2qm74	7562	24	.	.	.
cord-015021-pol2qm74	7563	1	Thus	thus	RB
cord-015021-pol2qm74	7563	2	,	,	,
cord-015021-pol2qm74	7563	3	the	the	DT
cord-015021-pol2qm74	7563	4	use	use	NN
cord-015021-pol2qm74	7563	5	of	of	IN
cord-015021-pol2qm74	7563	6	polyclonal	polyclonal	JJ
cord-015021-pol2qm74	7563	7	immunoglobulins	immunoglobulin	NNS
cord-015021-pol2qm74	7563	8	contrives	contrive	VBZ
cord-015021-pol2qm74	7563	9	to	to	TO
cord-015021-pol2qm74	7563	10	provide	provide	VB
cord-015021-pol2qm74	7563	11	an	an	DT
cord-015021-pol2qm74	7563	12	alternative	alternative	NN
cord-015021-pol2qm74	7563	13	and	and	CC
cord-015021-pol2qm74	7563	14	potentially	potentially	RB
cord-015021-pol2qm74	7563	15	cost	cost	VB
cord-015021-pol2qm74	7563	16	effective	effective	JJ
cord-015021-pol2qm74	7563	17	method	method	NN
cord-015021-pol2qm74	7563	18	for	for	IN
cord-015021-pol2qm74	7563	19	the	the	DT
cord-015021-pol2qm74	7563	20	treatment	treatment	NN
cord-015021-pol2qm74	7563	21	of	of	IN
cord-015021-pol2qm74	7563	22	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7563	23	shock	shock	NN
cord-015021-pol2qm74	7563	24	.	.	.
cord-015021-pol2qm74	7564	1	Supported	support	VBN
cord-015021-pol2qm74	7564	2	by	by	IN
cord-015021-pol2qm74	7564	3	R37	R37	NNP
cord-015021-pol2qm74	7564	4	A123447	A123447	NNP
cord-015021-pol2qm74	7564	5	and	and	CC
cord-015021-pol2qm74	7564	6	POt	POt	NNP
cord-015021-pol2qm74	7564	7	CA54474	CA54474	NNP
cord-015021-pol2qm74	7564	8	.	.	.
cord-015021-pol2qm74	7565	1	John	John	NNP
cord-015021-pol2qm74	7565	2	Holaday	Holaday	NNP
cord-015021-pol2qm74	7565	3	,	,	,
cord-015021-pol2qm74	7565	4	Anne	Anne	NNP
cord-015021-pol2qm74	7565	5	Fortier	Fortier	NNP
cord-015021-pol2qm74	7565	6	,	,	,
cord-015021-pol2qm74	7565	7	Shawn	Shawn	NNP
cord-015021-pol2qm74	7565	8	Green	Green	NNP
cord-015021-pol2qm74	7565	9	,	,	,
cord-015021-pol2qm74	7565	10	Glenn	Glenn	NNP
cord-015021-pol2qm74	7565	11	Swartz	Swartz	NNP
cord-015021-pol2qm74	7565	12	,	,	,
cord-015021-pol2qm74	7565	13	John	John	NNP
cord-015021-pol2qm74	7565	14	Madsen	Madsen	NNP
cord-015021-pol2qm74	7565	15	,	,	,
cord-015021-pol2qm74	7565	16	Carol	Carol	NNP
cord-015021-pol2qm74	7565	17	Naey	Naey	NNP
cord-015021-pol2qm74	7565	18	,	,	,
cord-015021-pol2qm74	7565	19	and	and	CC
cord-015021-pol2qm74	7565	20	Jan	Jan	NNP
cord-015021-pol2qm74	7565	21	DiJkstra	DiJkstra	NNP
cord-015021-pol2qm74	7565	22	EntreMed	EntreMed	NNP
cord-015021-pol2qm74	7565	23	,	,	,
cord-015021-pol2qm74	7565	24	Inc	Inc	NNP
cord-015021-pol2qm74	7565	25	..	..	NFP
cord-015021-pol2qm74	7565	26	Rockville	Rockville	NNP
cord-015021-pol2qm74	7565	27	,	,	,
cord-015021-pol2qm74	7565	28	MD	MD	NNP
cord-015021-pol2qm74	7565	29	,	,	,
cord-015021-pol2qm74	7565	30	20850	20850	CD
cord-015021-pol2qm74	7565	31	.	.	.
cord-015021-pol2qm74	7566	1	At	at	IN
cord-015021-pol2qm74	7566	2	the	the	DT
cord-015021-pol2qm74	7566	3	time	time	NN
cord-015021-pol2qm74	7566	4	of	of	IN
cord-015021-pol2qm74	7566	5	diagnosis	diagnosis	NN
cord-015021-pol2qm74	7566	6	,	,	,
cord-015021-pol2qm74	7566	7	the	the	DT
cord-015021-pol2qm74	7566	8	signs	sign	NNS
cord-015021-pol2qm74	7566	9	and	and	CC
cord-015021-pol2qm74	7566	10	symptoms	symptom	NNS
cord-015021-pol2qm74	7566	11	of	of	IN
cord-015021-pol2qm74	7566	12	septic	septic	JJ
cord-015021-pol2qm74	7566	13	shock	shock	NN
cord-015021-pol2qm74	7566	14	are	be	VBP
cord-015021-pol2qm74	7566	15	an	an	DT
cord-015021-pol2qm74	7566	16	indication	indication	NN
cord-015021-pol2qm74	7566	17	that	that	IN
cord-015021-pol2qm74	7566	18	the	the	DT
cord-015021-pol2qm74	7566	19	systemic	systemic	JJ
cord-015021-pol2qm74	7566	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7566	21	response	response	NN
cord-015021-pol2qm74	7566	22	is	be	VBZ
cord-015021-pol2qm74	7566	23	well	well	RB
cord-015021-pol2qm74	7566	24	underway	underway	JJ
cord-015021-pol2qm74	7566	25	;	;	:
cord-015021-pol2qm74	7566	26	thus	thus	RB
cord-015021-pol2qm74	7566	27	,	,	,
cord-015021-pol2qm74	7566	28	it	-PRON-	PRP
cord-015021-pol2qm74	7566	29	has	have	VBZ
cord-015021-pol2qm74	7566	30	been	be	VBN
cord-015021-pol2qm74	7566	31	argued	argue	VBN
cord-015021-pol2qm74	7566	32	that	that	IN
cord-015021-pol2qm74	7566	33	the	the	DT
cord-015021-pol2qm74	7566	34	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7566	35	"	"	''
cord-015021-pol2qm74	7566	36	cat	cat	NN
cord-015021-pol2qm74	7566	37	is	be	VBZ
cord-015021-pol2qm74	7566	38	out	out	IN
cord-015021-pol2qm74	7566	39	of	of	IN
cord-015021-pol2qm74	7566	40	the	the	DT
cord-015021-pol2qm74	7566	41	bag	bag	NN
cord-015021-pol2qm74	7566	42	"	"	''
cord-015021-pol2qm74	7566	43	,	,	,
cord-015021-pol2qm74	7566	44	and	and	CC
cord-015021-pol2qm74	7566	45	that	that	IN
cord-015021-pol2qm74	7566	46	subsequent	subsequent	JJ
cord-015021-pol2qm74	7566	47	passive	passive	JJ
cord-015021-pol2qm74	7566	48	immunization	immunization	NN
cord-015021-pol2qm74	7566	49	may	may	MD
cord-015021-pol2qm74	7566	50	be	be	VB
cord-015021-pol2qm74	7566	51	too	too	RB
cord-015021-pol2qm74	7566	52	late	late	JJ
cord-015021-pol2qm74	7566	53	to	to	TO
cord-015021-pol2qm74	7566	54	achieve	achieve	VB
cord-015021-pol2qm74	7566	55	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7566	56	benefit	benefit	NN
cord-015021-pol2qm74	7566	57	.	.	.
cord-015021-pol2qm74	7567	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	7567	2	approach	approach	NN
cord-015021-pol2qm74	7567	3	has	have	VBZ
cord-015021-pol2qm74	7567	4	been	be	VBN
cord-015021-pol2qm74	7567	5	to	to	TO
cord-015021-pol2qm74	7567	6	evaluate	evaluate	VB
cord-015021-pol2qm74	7567	7	active	active	JJ
cord-015021-pol2qm74	7567	8	immunization	immunization	NN
cord-015021-pol2qm74	7567	9	as	as	IN
cord-015021-pol2qm74	7567	10	a	a	DT
cord-015021-pol2qm74	7567	11	prophylax	prophylax	NN
cord-015021-pol2qm74	7567	12	~	~	NFP
cord-015021-pol2qm74	7567	13	s	s	XX
cord-015021-pol2qm74	7567	14	against	against	IN
cord-015021-pol2qm74	7567	15	sepsis	sepsis	NN
cord-015021-pol2qm74	7567	16	.	.	.
cord-015021-pol2qm74	7568	1	Mice	mouse	NNS
cord-015021-pol2qm74	7568	2	were	be	VBD
cord-015021-pol2qm74	7568	3	inoculated	inoculate	VBN
cord-015021-pol2qm74	7568	4	twice	twice	RB
cord-015021-pol2qm74	7568	5	(	(	-LRB-
cord-015021-pol2qm74	7568	6	two	two	CD
cord-015021-pol2qm74	7568	7	weeks	week	NNS
cord-015021-pol2qm74	7568	8	apart	apart	RB
cord-015021-pol2qm74	7568	9	)	)	-RRB-
cord-015021-pol2qm74	7568	10	with	with	IN
cord-015021-pol2qm74	7568	11	liposomes	liposome	NNS
cord-015021-pol2qm74	7568	12	containing	contain	VBG
cord-015021-pol2qm74	7568	13	DMPC[I.8	DMPC[I.8	NNP
cord-015021-pol2qm74	7568	14	]	]	-RRB-
cord-015021-pol2qm74	7568	15	,	,	,
cord-015021-pol2qm74	7568	16	DMPG[0.2	DMPG[0.2	NNP
cord-015021-pol2qm74	7568	17	]	]	-RRB-
cord-015021-pol2qm74	7568	18	,	,	,
cord-015021-pol2qm74	7568	19	cholesterol	cholesterol	NN
cord-015021-pol2qm74	7568	20	[	[	-LRB-
cord-015021-pol2qm74	7568	21	1.5	1.5	CD
cord-015021-pol2qm74	7568	22	]	]	-RRB-
cord-015021-pol2qm74	7568	23	,	,	,
cord-015021-pol2qm74	7568	24	and	and	CC
cord-015021-pol2qm74	7569	1	monophosphoryl	monophosphoryl	NNP
cord-015021-pol2qm74	7569	2	lipid	lipid	VBG
cord-015021-pol2qm74	7569	3	A	a	DT
cord-015021-pol2qm74	7569	4	[	[	-LRB-
cord-015021-pol2qm74	7569	5	20	20	CD
cord-015021-pol2qm74	7569	6	-	-	SYM
cord-015021-pol2qm74	7569	7	200	200	CD
cord-015021-pol2qm74	7569	8	gg	gg	NNP
cord-015021-pol2qm74	7569	9	/	/	SYM
cord-015021-pol2qm74	7569	10	txmole	txmole	NNP
cord-015021-pol2qm74	7569	11	phospholipid	phospholipid	NN
cord-015021-pol2qm74	7569	12	]	]	-RRB-
cord-015021-pol2qm74	7569	13	by	by	IN
cord-015021-pol2qm74	7569	14	several	several	JJ
cord-015021-pol2qm74	7569	15	routes	route	NNS
cord-015021-pol2qm74	7569	16	(	(	-LRB-
cord-015021-pol2qm74	7569	17	i.p	i.p	NNP
cord-015021-pol2qm74	7569	18	.	.	NNP
cord-015021-pol2qm74	7569	19	,	,	,
cord-015021-pol2qm74	7569	20	i.m	i.m	NNP
cord-015021-pol2qm74	7569	21	.	.	NNP
cord-015021-pol2qm74	7569	22	)	)	-RRB-
cord-015021-pol2qm74	7569	23	,	,	,
cord-015021-pol2qm74	7569	24	and	and	CC
cord-015021-pol2qm74	7570	1	serum	serum	NN
cord-015021-pol2qm74	7570	2	was	be	VBD
cord-015021-pol2qm74	7570	3	collected	collect	VBN
cord-015021-pol2qm74	7570	4	10	10	CD
cord-015021-pol2qm74	7570	5	-	-	SYM
cord-015021-pol2qm74	7570	6	11	11	CD
cord-015021-pol2qm74	7570	7	days	day	NNS
cord-015021-pol2qm74	7570	8	after	after	IN
cord-015021-pol2qm74	7570	9	each	each	DT
cord-015021-pol2qm74	7570	10	inoculation	inoculation	NN
cord-015021-pol2qm74	7570	11	.	.	.
cord-015021-pol2qm74	7571	1	After	after	IN
cord-015021-pol2qm74	7571	2	a	a	DT
cord-015021-pol2qm74	7571	3	single	single	JJ
cord-015021-pol2qm74	7571	4	injection	injection	NN
cord-015021-pol2qm74	7571	5	,	,	,
cord-015021-pol2qm74	7571	6	highest	high	JJS
cord-015021-pol2qm74	7571	7	tilers	tiler	NNS
cord-015021-pol2qm74	7571	8	of	of	IN
cord-015021-pol2qm74	7571	9	Ab	Ab	NNP
cord-015021-pol2qm74	7571	10	were	be	VBD
cord-015021-pol2qm74	7571	11	produced	produce	VBN
cord-015021-pol2qm74	7571	12	in	in	IN
cord-015021-pol2qm74	7571	13	mice	mouse	NNS
cord-015021-pol2qm74	7571	14	inoculated	inoculate	VBD
cord-015021-pol2qm74	7571	15	i.p	i.p	NNP
cord-015021-pol2qm74	7571	16	.	.	NNP
cord-015021-pol2qm74	7571	17	,	,	,
cord-015021-pol2qm74	7571	18	but	but	CC
cord-015021-pol2qm74	7572	1	mice	mouse	NNS
cord-015021-pol2qm74	7572	2	inoculated	inoculate	VBN
cord-015021-pol2qm74	7572	3	by	by	IN
cord-015021-pol2qm74	7572	4	all	all	DT
cord-015021-pol2qm74	7572	5	routes	route	NNS
cord-015021-pol2qm74	7572	6	produced	produce	VBD
cord-015021-pol2qm74	7572	7	anti	anti	JJ
cord-015021-pol2qm74	7572	8	-	-	JJ
cord-015021-pol2qm74	7572	9	lipid	lipid	JJ
cord-015021-pol2qm74	7572	10	A	a	DT
cord-015021-pol2qm74	7572	11	Ab	ab	NN
cord-015021-pol2qm74	7572	12	.	.	.
cord-015021-pol2qm74	7573	1	Following	follow	VBG
cord-015021-pol2qm74	7573	2	the	the	DT
cord-015021-pol2qm74	7573	3	second	second	JJ
cord-015021-pol2qm74	7573	4	injection	injection	NN
cord-015021-pol2qm74	7573	5	.	.	.
cord-015021-pol2qm74	7574	1	Ab	Ab	NNP
cord-015021-pol2qm74	7574	2	levels	level	NNS
cord-015021-pol2qm74	7574	3	were	be	VBD
cord-015021-pol2qm74	7574	4	roughly	roughly	RB
cord-015021-pol2qm74	7574	5	equivalent	equivalent	JJ
cord-015021-pol2qm74	7574	6	in	in	IN
cord-015021-pol2qm74	7574	7	mice	mouse	NNS
cord-015021-pol2qm74	7574	8	inoculated	inoculate	VBN
cord-015021-pol2qm74	7574	9	by	by	IN
cord-015021-pol2qm74	7574	10	all	all	DT
cord-015021-pol2qm74	7574	11	routes	route	NNS
cord-015021-pol2qm74	7574	12	,	,	,
cord-015021-pol2qm74	7574	13	regardless	regardless	RB
cord-015021-pol2qm74	7574	14	of	of	IN
cord-015021-pol2qm74	7574	15	lipid	lipid	NN
cord-015021-pol2qm74	7574	16	A	a	DT
cord-015021-pol2qm74	7574	17	concentration	concentration	NN
cord-015021-pol2qm74	7574	18	.	.	.
cord-015021-pol2qm74	7575	1	Mice	mouse	NNS
cord-015021-pol2qm74	7575	2	vaccinated	vaccinate	VBD
cord-015021-pol2qm74	7575	3	i.p	i.p	NNP
cord-015021-pol2qm74	7575	4	.	.	.
cord-015021-pol2qm74	7576	1	with	with	IN
cord-015021-pol2qm74	7576	2	liposomes	liposome	NNS
cord-015021-pol2qm74	7576	3	containing	contain	VBG
cord-015021-pol2qm74	7576	4	0	0	CD
cord-015021-pol2qm74	7576	5	,	,	,
cord-015021-pol2qm74	7576	6	20	20	CD
cord-015021-pol2qm74	7576	7	or	or	CC
cord-015021-pol2qm74	7576	8	200	200	CD
cord-015021-pol2qm74	7576	9	gg	gg	NN
cord-015021-pol2qm74	7576	10	lipid	lipid	NN
cord-015021-pol2qm74	7576	11	A	A	NNP
cord-015021-pol2qm74	7576	12	were	be	VBD
cord-015021-pol2qm74	7576	13	treated	treat	VBN
cord-015021-pol2qm74	7576	14	with	with	IN
cord-015021-pol2qm74	7576	15	cyclophosphamide	cyclophosphamide	NN
cord-015021-pol2qm74	7576	16	to	to	TO
cord-015021-pol2qm74	7576	17	produce	produce	VB
cord-015021-pol2qm74	7576	18	neutroperda	neutroperda	NN
cord-015021-pol2qm74	7576	19	and	and	CC
cord-015021-pol2qm74	7576	20	then	then	RB
cord-015021-pol2qm74	7576	21	challenged	challenge	VBD
cord-015021-pol2qm74	7576	22	with	with	IN
cord-015021-pol2qm74	7576	23	E.	E.	NNP
cord-015021-pol2qm74	7576	24	cole	cole	NNP
cord-015021-pol2qm74	7576	25	in	in	IN
cord-015021-pol2qm74	7576	26	an	an	DT
cord-015021-pol2qm74	7576	27	infection	infection	NN
cord-015021-pol2qm74	7576	28	model	model	NN
cord-015021-pol2qm74	7576	29	of	of	IN
cord-015021-pol2qm74	7576	30	gram	gram	NN
cord-015021-pol2qm74	7576	31	negative	negative	JJ
cord-015021-pol2qm74	7576	32	sepsis	sepsis	NN
cord-015021-pol2qm74	7576	33	.	.	.
cord-015021-pol2qm74	7577	1	The	the	DT
cord-015021-pol2qm74	7577	2	LDS0	LDS0	NNP
cord-015021-pol2qm74	7577	3	for	for	IN
cord-015021-pol2qm74	7577	4	control	control	NN
cord-015021-pol2qm74	7577	5	(	(	-LRB-
cord-015021-pol2qm74	7577	6	liposomes	liposome	NNS
cord-015021-pol2qm74	7577	7	with	with	IN
cord-015021-pol2qm74	7577	8	no	no	DT
cord-015021-pol2qm74	7577	9	lipid	lipid	NN
cord-015021-pol2qm74	7577	10	A	a	NN
cord-015021-pol2qm74	7577	11	)	)	-RRB-
cord-015021-pol2qm74	7577	12	mice	mice	NN
cord-015021-pol2qm74	7577	13	was	be	VBD
cord-015021-pol2qm74	7577	14	3x10	3x10	CD
cord-015021-pol2qm74	7577	15	bacteria	bacteria	NNS
cord-015021-pol2qm74	7577	16	;	;	:
cord-015021-pol2qm74	7577	17	LD50	LD50	NNP
cord-015021-pol2qm74	7577	18	for	for	IN
cord-015021-pol2qm74	7577	19	mice	mouse	NNS
cord-015021-pol2qm74	7577	20	vaccinated	vaccinate	VBN
cord-015021-pol2qm74	7577	21	with	with	IN
cord-015021-pol2qm74	7577	22	20p.g	20p.g	CD
cord-015021-pol2qm74	7577	23	was	be	VBD
cord-015021-pol2qm74	7577	24	24x103	24x103	NNS
cord-015021-pol2qm74	7578	1	(	(	-LRB-
cord-015021-pol2qm74	7578	2	8-fold	8-fold	CD
cord-015021-pol2qm74	7578	3	increase	increase	NN
cord-015021-pol2qm74	7578	4	in	in	IN
cord-015021-pol2qm74	7578	5	resistance	resistance	NN
cord-015021-pol2qm74	7578	6	)	)	-RRB-
cord-015021-pol2qm74	7579	1	and	and	CC
cord-015021-pol2qm74	7579	2	with	with	IN
cord-015021-pol2qm74	7579	3	200~tg	200~tg	CD
cord-015021-pol2qm74	7579	4	was	be	VBD
cord-015021-pol2qm74	7579	5	48x103	48x103	CD
cord-015021-pol2qm74	7579	6	bacteria	bacteria	NNS
cord-015021-pol2qm74	7579	7	(	(	-LRB-
cord-015021-pol2qm74	7579	8	16-laid	16-laid	CD
cord-015021-pol2qm74	7579	9	increase	increase	NN
cord-015021-pol2qm74	7579	10	in	in	IN
cord-015021-pol2qm74	7579	11	resistance	resistance	NN
cord-015021-pol2qm74	7579	12	)	)	-RRB-
cord-015021-pol2qm74	7579	13	.	.	.
cord-015021-pol2qm74	7580	1	Mice	mouse	NNS
cord-015021-pol2qm74	7580	2	vaccinated	vaccinate	VBN
cord-015021-pol2qm74	7580	3	as	as	IN
cord-015021-pol2qm74	7580	4	before	before	RB
cord-015021-pol2qm74	7580	5	were	be	VBD
cord-015021-pol2qm74	7580	6	also	also	RB
cord-015021-pol2qm74	7580	7	treated	treat	VBN
cord-015021-pol2qm74	7580	8	with	with	IN
cord-015021-pol2qm74	7580	9	Actinomyein	Actinomyein	NNP
cord-015021-pol2qm74	7580	10	D	D	NNP
cord-015021-pol2qm74	7580	11	to	to	TO
cord-015021-pol2qm74	7580	12	increase	increase	VB
cord-015021-pol2qm74	7580	13	sensitivity	sensitivity	NN
cord-015021-pol2qm74	7580	14	to	to	IN
cord-015021-pol2qm74	7580	15	LPS	LPS	NNP
cord-015021-pol2qm74	7580	16	(	(	-LRB-
cord-015021-pol2qm74	7580	17	Salmonella	Salmonella	NNP
cord-015021-pol2qm74	7580	18	minnesota	minnesota	NNP
cord-015021-pol2qm74	7580	19	)	)	-RRB-
cord-015021-pol2qm74	7580	20	challenge	challenge	VBP
cord-015021-pol2qm74	7580	21	in	in	IN
cord-015021-pol2qm74	7580	22	an	an	DT
cord-015021-pol2qm74	7580	23	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7580	24	model	model	NN
cord-015021-pol2qm74	7580	25	of	of	IN
cord-015021-pol2qm74	7580	26	grain	grain	NN
cord-015021-pol2qm74	7580	27	negative	negative	JJ
cord-015021-pol2qm74	7580	28	sepsis	sepsis	NN
cord-015021-pol2qm74	7580	29	.	.	.
cord-015021-pol2qm74	7581	1	The	the	DT
cord-015021-pol2qm74	7581	2	LD50	LD50	NNP
cord-015021-pol2qm74	7581	3	for	for	IN
cord-015021-pol2qm74	7581	4	control	control	NN
cord-015021-pol2qm74	7581	5	(	(	-LRB-
cord-015021-pol2qm74	7581	6	liposomes	liposome	NNS
cord-015021-pol2qm74	7581	7	with	with	IN
cord-015021-pol2qm74	7581	8	no	no	DT
cord-015021-pol2qm74	7581	9	lipid	lipid	NN
cord-015021-pol2qm74	7581	10	A	a	NN
cord-015021-pol2qm74	7581	11	)	)	-RRB-
cord-015021-pol2qm74	7581	12	mice	mice	NN
cord-015021-pol2qm74	7581	13	was	be	VBD
cord-015021-pol2qm74	7581	14	30	30	CD
cord-015021-pol2qm74	7581	15	ng	ng	NN
cord-015021-pol2qm74	7581	16	LPS	lp	NNS
cord-015021-pol2qm74	7581	17	;	;	:
cord-015021-pol2qm74	7581	18	the	the	DT
cord-015021-pol2qm74	7581	19	LD50	LD50	NNP
cord-015021-pol2qm74	7581	20	for	for	IN
cord-015021-pol2qm74	7582	1	20gg	20gg	JJ
cord-015021-pol2qm74	7582	2	lipid	lipid	NN
cord-015021-pol2qm74	7582	3	A	A	NNP
cord-015021-pol2qm74	7582	4	was	be	VBD
cord-015021-pol2qm74	7582	5	70rig	70rig	JJ
cord-015021-pol2qm74	7582	6	LPS	lp	NNS
cord-015021-pol2qm74	7582	7	(	(	-LRB-
cord-015021-pol2qm74	7582	8	2-fold	2-fold	CD
cord-015021-pol2qm74	7582	9	increase	increase	NN
cord-015021-pol2qm74	7582	10	in	in	IN
cord-015021-pol2qm74	7582	11	resistance	resistance	NN
cord-015021-pol2qm74	7582	12	)	)	-RRB-
cord-015021-pol2qm74	7582	13	and	and	CC
cord-015021-pol2qm74	7582	14	for	for	IN
cord-015021-pol2qm74	7582	15	2001xg	2001xg	NNP
cord-015021-pol2qm74	7582	16	was	be	VBD
cord-015021-pol2qm74	7582	17	570ng	570ng	JJ
cord-015021-pol2qm74	7582	18	LPS	LPS	NNP
cord-015021-pol2qm74	7582	19	(	(	-LRB-
cord-015021-pol2qm74	7582	20	19-fold	19-fold	CD
cord-015021-pol2qm74	7582	21	increase	increase	NN
cord-015021-pol2qm74	7582	22	in	in	IN
cord-015021-pol2qm74	7582	23	resistance	resistance	NN
cord-015021-pol2qm74	7582	24	)	)	-RRB-
cord-015021-pol2qm74	7582	25	.	.	.
cord-015021-pol2qm74	7583	1	Mice	mouse	NNS
cord-015021-pol2qm74	7583	2	were	be	VBD
cord-015021-pol2qm74	7583	3	similarly	similarly	RB
cord-015021-pol2qm74	7583	4	vaccinated	vaccinate	VBN
cord-015021-pol2qm74	7583	5	and	and	CC
cord-015021-pol2qm74	7583	6	challenged	challenge	VBN
cord-015021-pol2qm74	7583	7	with	with	IN
cord-015021-pol2qm74	7583	8	an	an	DT
cord-015021-pol2qm74	7583	9	aggressive	aggressive	JJ
cord-015021-pol2qm74	7583	10	gram	gram	NN
cord-015021-pol2qm74	7583	11	negative	negative	JJ
cord-015021-pol2qm74	7583	12	pathogen	pathogen	NN
cord-015021-pol2qm74	7583	13	,	,	,
cord-015021-pol2qm74	7583	14	Francfsella	Francfsella	NNP
cord-015021-pol2qm74	7583	15	tularensis	tularensis	NNP
cord-015021-pol2qm74	7583	16	.	.	.
cord-015021-pol2qm74	7584	1	The	the	DT
cord-015021-pol2qm74	7584	2	LD50	LD50	NNP
cord-015021-pol2qm74	7584	3	of	of	IN
cord-015021-pol2qm74	7584	4	FranciseUa	FranciseUa	NNP
cord-015021-pol2qm74	7584	5	in	in	IN
cord-015021-pol2qm74	7584	6	normal	normal	JJ
cord-015021-pol2qm74	7584	7	mice	mouse	NNS
cord-015021-pol2qm74	7584	8	or	or	CC
cord-015021-pol2qm74	7584	9	mice	mouse	NNS
cord-015021-pol2qm74	7584	10	inoculated	inoculate	VBN
cord-015021-pol2qm74	7584	11	with	with	IN
cord-015021-pol2qm74	7584	12	liposomes	liposome	NNS
cord-015021-pol2qm74	7584	13	without	without	IN
cord-015021-pol2qm74	7584	14	lipid	lipid	NN
cord-015021-pol2qm74	7584	15	A	A	NNP
cord-015021-pol2qm74	7584	16	was	be	VBD
cord-015021-pol2qm74	7584	17	20	20	CD
cord-015021-pol2qm74	7584	18	-	-	SYM
cord-015021-pol2qm74	7584	19	40	40	CD
cord-015021-pol2qm74	7584	20	bacteria	bacteria	NNS
cord-015021-pol2qm74	7584	21	.	.	.
cord-015021-pol2qm74	7585	1	In	in	IN
cord-015021-pol2qm74	7585	2	contrast	contrast	NN
cord-015021-pol2qm74	7585	3	,	,	,
cord-015021-pol2qm74	7585	4	mice	mouse	NNS
cord-015021-pol2qm74	7585	5	vaccinated	vaccinate	VBN
cord-015021-pol2qm74	7585	6	with	with	IN
cord-015021-pol2qm74	7585	7	liposomal	liposomal	JJ
cord-015021-pol2qm74	7585	8	lipid	lipid	NN
cord-015021-pol2qm74	7585	9	A	a	NN
cord-015021-pol2qm74	7585	10	(	(	-LRB-
cord-015021-pol2qm74	7586	1	200ggl	200ggl	CD
cord-015021-pol2qm74	7586	2	survived	survive	VBD
cord-015021-pol2qm74	7586	3	challenges	challenge	NNS
cord-015021-pol2qm74	7586	4	as	as	RB
cord-015021-pol2qm74	7586	5	high	high	JJ
cord-015021-pol2qm74	7586	6	as	as	IN
cord-015021-pol2qm74	7586	7	30,000	30,000	CD
cord-015021-pol2qm74	7586	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	7586	9	,	,	,
cord-015021-pol2qm74	7586	10	(	(	-LRB-
cord-015021-pol2qm74	7586	11	3	3	CD
cord-015021-pol2qm74	7586	12	logs	log	NNS
cord-015021-pol2qm74	7586	13	of	of	IN
cord-015021-pol2qm74	7586	14	protection	protection	NN
cord-015021-pol2qm74	7586	15	)	)	-RRB-
cord-015021-pol2qm74	7586	16	.	.	.
cord-015021-pol2qm74	7587	1	The	the	DT
cord-015021-pol2qm74	7587	2	impressive	impressive	JJ
cord-015021-pol2qm74	7587	3	protective	protective	JJ
cord-015021-pol2qm74	7587	4	capacity	capacity	NN
cord-015021-pol2qm74	7587	5	of	of	IN
cord-015021-pol2qm74	7587	6	this	this	DT
cord-015021-pol2qm74	7587	7	vaccine	vaccine	NN
cord-015021-pol2qm74	7587	8	did	do	VBD
cord-015021-pol2qm74	7587	9	not	not	RB
cord-015021-pol2qm74	7587	10	correlate	correlate	VB
cord-015021-pol2qm74	7587	11	with	with	IN
cord-015021-pol2qm74	7587	12	Ab	Ab	NNP
cord-015021-pol2qm74	7587	13	Liter	Liter	NNP
cord-015021-pol2qm74	7587	14	in	in	IN
cord-015021-pol2qm74	7587	15	any	any	DT
cord-015021-pol2qm74	7587	16	of	of	IN
cord-015021-pol2qm74	7587	17	the	the	DT
cord-015021-pol2qm74	7587	18	sepsis	sepsis	NN
cord-015021-pol2qm74	7587	19	models	model	NNS
cord-015021-pol2qm74	7587	20	,	,	,
cord-015021-pol2qm74	7587	21	nor	nor	CC
cord-015021-pol2qm74	7587	22	did	do	VBD
cord-015021-pol2qm74	7587	23	it	-PRON-	PRP
cord-015021-pol2qm74	7587	24	correlate	correlate	VB
cord-015021-pol2qm74	7587	25	with	with	IN
cord-015021-pol2qm74	7587	26	classic	classic	JJ
cord-015021-pol2qm74	7587	27	nonspeeific	nonspeeific	JJ
cord-015021-pol2qm74	7587	28	events	event	NNS
cord-015021-pol2qm74	7587	29	,	,	,
cord-015021-pol2qm74	7587	30	such	such	JJ
cord-015021-pol2qm74	7587	31	as	as	IN
cord-015021-pol2qm74	7587	32	macrophage	macrophage	NN
cord-015021-pol2qm74	7587	33	activation	activation	NN
cord-015021-pol2qm74	7587	34	.	.	.
cord-015021-pol2qm74	7588	1	Maerophages	maerophage	NNS
cord-015021-pol2qm74	7588	2	harvested	harvest	VBN
cord-015021-pol2qm74	7588	3	from	from	IN
cord-015021-pol2qm74	7588	4	the	the	DT
cord-015021-pol2qm74	7588	5	peritoneum	peritoneum	NN
cord-015021-pol2qm74	7588	6	of	of	IN
cord-015021-pol2qm74	7588	7	mice	mouse	NNS
cord-015021-pol2qm74	7588	8	vaccinated	vaccinate	VBN
cord-015021-pol2qm74	7588	9	and	and	CC
cord-015021-pol2qm74	7588	10	protected	protect	VBN
cord-015021-pol2qm74	7588	11	against	against	IN
cord-015021-pol2qm74	7588	12	sequelae	sequela	NNS
cord-015021-pol2qm74	7588	13	of	of	IN
cord-015021-pol2qm74	7588	14	gram	gram	NN
cord-015021-pol2qm74	7588	15	negative	negative	JJ
cord-015021-pol2qm74	7588	16	infections	infection	NNS
cord-015021-pol2qm74	7588	17	did	do	VBD
cord-015021-pol2qm74	7588	18	not	not	RB
cord-015021-pol2qm74	7588	19	spontaneously	spontaneously	RB
cord-015021-pol2qm74	7588	20	kill	kill	VB
cord-015021-pol2qm74	7588	21	the	the	DT
cord-015021-pol2qm74	7588	22	bacteria	bacteria	NNS
cord-015021-pol2qm74	7588	23	in	in	IN
cord-015021-pol2qm74	7588	24	vitro	vitro	FW
cord-015021-pol2qm74	7588	25	,	,	,
cord-015021-pol2qm74	7588	26	but	but	CC
cord-015021-pol2qm74	7588	27	could	could	MD
cord-015021-pol2qm74	7588	28	be	be	VB
cord-015021-pol2qm74	7588	29	activated	activate	VBN
cord-015021-pol2qm74	7588	30	by	by	IN
cord-015021-pol2qm74	7588	31	IFN	IFN	NNP
cord-015021-pol2qm74	7588	32	-	-	HYPH
cord-015021-pol2qm74	7588	33	y	y	NNP
cord-015021-pol2qm74	7588	34	for	for	IN
cord-015021-pol2qm74	7588	35	antimicrobial	antimicrobial	JJ
cord-015021-pol2qm74	7588	36	activity	activity	NN
cord-015021-pol2qm74	7588	37	equivalent	equivalent	JJ
cord-015021-pol2qm74	7588	38	to	to	IN
cord-015021-pol2qm74	7588	39	that	that	DT
cord-015021-pol2qm74	7588	40	of	of	IN
cord-015021-pol2qm74	7588	41	macrophages	macrophage	NNS
cord-015021-pol2qm74	7588	42	from	from	IN
cord-015021-pol2qm74	7588	43	unt#eated	unt#eated	NNP
cord-015021-pol2qm74	7588	44	mice	mouse	NNS
cord-015021-pol2qm74	7588	45	.	.	.
cord-015021-pol2qm74	7589	1	Research	research	NN
cord-015021-pol2qm74	7589	2	is	be	VBZ
cord-015021-pol2qm74	7589	3	underway	underway	JJ
cord-015021-pol2qm74	7589	4	to	to	TO
cord-015021-pol2qm74	7589	5	defme	defme	VB
cord-015021-pol2qm74	7589	6	the	the	DT
cord-015021-pol2qm74	7589	7	protective	protective	JJ
cord-015021-pol2qm74	7589	8	mechanism(s	mechanism(s	NN
cord-015021-pol2qm74	7589	9	)	)	-RRB-
cord-015021-pol2qm74	7590	1	activated	activate	VBN
cord-015021-pol2qm74	7590	2	by	by	IN
cord-015021-pol2qm74	7590	3	this	this	DT
cord-015021-pol2qm74	7590	4	liposomal	liposomal	NN
cord-015021-pol2qm74	7590	5	-	-	HYPH
cord-015021-pol2qm74	7590	6	Lipid	lipid	NN
cord-015021-pol2qm74	7590	7	A	a	DT
cord-015021-pol2qm74	7590	8	vaccine	vaccine	NN
cord-015021-pol2qm74	7590	9	.	.	.
cord-015021-pol2qm74	7591	1	INTERVENTION	intervention	NN
cord-015021-pol2qm74	7591	2	BY	by	IN
cord-015021-pol2qm74	7591	3	MONOPHOSPHORYL	MONOPHOSPHORYL	NNP
cord-015021-pol2qm74	7591	4	LIPID	LIPID	NNP
cord-015021-pol2qm74	7591	5	A	a	DT
cord-015021-pol2qm74	7592	1	IN	in	IN
cord-015021-pol2qm74	7592	2	SEPTIC	septic	JJ
cord-015021-pol2qm74	7592	3	SHOCK	shock	NN
cord-015021-pol2qm74	7593	1	Jon	Jon	NNP
cord-015021-pol2qm74	7593	2	A.	A.	NNP
cord-015021-pol2qm74	7593	3	Rudbach	Rudbach	NNP
cord-015021-pol2qm74	7593	4	,	,	,
cord-015021-pol2qm74	7593	5	Ribi	Ribi	NNP
cord-015021-pol2qm74	7593	6	ImmunoChem	ImmunoChem	NNP
cord-015021-pol2qm74	7593	7	Research	Research	NNP
cord-015021-pol2qm74	7593	8	,	,	,
cord-015021-pol2qm74	7593	9	Inc.	Inc.	NNP
cord-015021-pol2qm74	7593	10	,	,	,
cord-015021-pol2qm74	7593	11	Hamilton	Hamilton	NNP
cord-015021-pol2qm74	7593	12	,	,	,
cord-015021-pol2qm74	7593	13	Montana	Montana	NNP
cord-015021-pol2qm74	7593	14	,	,	,
cord-015021-pol2qm74	7593	15	USA	USA	NNP
cord-015021-pol2qm74	7593	16	Monophosphoryl	Monophosphoryl	NNP
cord-015021-pol2qm74	7593	17	Lipid	Lipid	NNP
cord-015021-pol2qm74	7593	18	A	A	NNP
cord-015021-pol2qm74	7593	19	(	(	-LRB-
cord-015021-pol2qm74	7593	20	MLA	MLA	NNP
cord-015021-pol2qm74	7593	21	)	)	-RRB-
cord-015021-pol2qm74	7593	22	,	,	,
cord-015021-pol2qm74	7593	23	the	the	DT
cord-015021-pol2qm74	7593	24	clinical	clinical	JJ
cord-015021-pol2qm74	7593	25	form	form	NN
cord-015021-pol2qm74	7593	26	of	of	IN
cord-015021-pol2qm74	7593	27	which	which	WDT
cord-015021-pol2qm74	7593	28	is	be	VBZ
cord-015021-pol2qm74	7593	29	called	call	VBN
cord-015021-pol2qm74	7593	30	MPL	MPL	NNP
cord-015021-pol2qm74	7593	31	®	®	NNP
cord-015021-pol2qm74	7593	32	-immunostimulant	-immunostimulant	CD
cord-015021-pol2qm74	7593	33	,	,	,
cord-015021-pol2qm74	7593	34	has	have	VBZ
cord-015021-pol2qm74	7593	35	been	be	VBN
cord-015021-pol2qm74	7593	36	tested	test	VBN
cord-015021-pol2qm74	7593	37	extensively	extensively	RB
cord-015021-pol2qm74	7593	38	as	as	IN
cord-015021-pol2qm74	7593	39	an	an	DT
cord-015021-pol2qm74	7593	40	intervenient	intervenient	NN
cord-015021-pol2qm74	7593	41	material	material	NN
cord-015021-pol2qm74	7593	42	in	in	IN
cord-015021-pol2qm74	7593	43	septic	septic	JJ
cord-015021-pol2qm74	7593	44	shock	shock	NN
cord-015021-pol2qm74	7593	45	.	.	.
cord-015021-pol2qm74	7594	1	MLA	MLA	NNP
cord-015021-pol2qm74	7594	2	is	be	VBZ
cord-015021-pol2qm74	7594	3	protective	protective	JJ
cord-015021-pol2qm74	7594	4	when	when	WRB
cord-015021-pol2qm74	7594	5	given	give	VBN
cord-015021-pol2qm74	7594	6	to	to	IN
cord-015021-pol2qm74	7594	7	experimental	experimental	JJ
cord-015021-pol2qm74	7594	8	animals	animal	NNS
cord-015021-pol2qm74	7594	9	prior	prior	RB
cord-015021-pol2qm74	7594	10	to	to	IN
cord-015021-pol2qm74	7594	11	a	a	DT
cord-015021-pol2qm74	7594	12	live	live	JJ
cord-015021-pol2qm74	7594	13	microbial	microbial	JJ
cord-015021-pol2qm74	7594	14	challenge	challenge	NN
cord-015021-pol2qm74	7594	15	or	or	CC
cord-015021-pol2qm74	7594	16	challenge	challenge	NN
cord-015021-pol2qm74	7594	17	with	with	IN
cord-015021-pol2qm74	7594	18	lethal	lethal	JJ
cord-015021-pol2qm74	7594	19	doses	dose	NNS
cord-015021-pol2qm74	7594	20	of	of	IN
cord-015021-pol2qm74	7594	21	microbial	microbial	JJ
cord-015021-pol2qm74	7594	22	products	product	NNS
cord-015021-pol2qm74	7594	23	or	or	CC
cord-015021-pol2qm74	7594	24	certain	certain	JJ
cord-015021-pol2qm74	7594	25	cytokines	cytokine	NNS
cord-015021-pol2qm74	7594	26	.	.	.
cord-015021-pol2qm74	7595	1	This	this	DT
cord-015021-pol2qm74	7595	2	is	be	VBZ
cord-015021-pol2qm74	7595	3	shown	show	VBN
cord-015021-pol2qm74	7595	4	with	with	IN
cord-015021-pol2qm74	7595	5	Gram	Gram	NNP
cord-015021-pol2qm74	7595	6	negative	negative	JJ
cord-015021-pol2qm74	7595	7	and	and	CC
cord-015021-pol2qm74	7595	8	Gram	Gram	NNP
cord-015021-pol2qm74	7595	9	positive	positive	JJ
cord-015021-pol2qm74	7595	10	bacteria	bacteria	NNS
cord-015021-pol2qm74	7595	11	,	,	,
cord-015021-pol2qm74	7595	12	Gram	Gram	NNP
cord-015021-pol2qm74	7595	13	negative	negative	JJ
cord-015021-pol2qm74	7595	14	bacterial	bacterial	JJ
cord-015021-pol2qm74	7595	15	endotoxins	endotoxin	NNS
cord-015021-pol2qm74	7595	16	,	,	,
cord-015021-pol2qm74	7595	17	and	and	CC
cord-015021-pol2qm74	7595	18	Gram	Gram	NNP
cord-015021-pol2qm74	7595	19	positive	positive	JJ
cord-015021-pol2qm74	7595	20	bacterial	bacterial	JJ
cord-015021-pol2qm74	7595	21	exotoxins	exotoxin	NNS
cord-015021-pol2qm74	7595	22	.	.	.
cord-015021-pol2qm74	7596	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	7596	2	,	,	,
cord-015021-pol2qm74	7596	3	animals	animal	NNS
cord-015021-pol2qm74	7596	4	treated	treat	VBN
cord-015021-pol2qm74	7596	5	with	with	IN
cord-015021-pol2qm74	7596	6	a	a	DT
cord-015021-pol2qm74	7596	7	regimen	regimen	NN
cord-015021-pol2qm74	7596	8	of	of	IN
cord-015021-pol2qm74	7596	9	MLA	MLA	NNP
cord-015021-pol2qm74	7596	10	which	which	WDT
cord-015021-pol2qm74	7596	11	results	result	VBZ
cord-015021-pol2qm74	7596	12	in	in	IN
cord-015021-pol2qm74	7596	13	a	a	DT
cord-015021-pol2qm74	7596	14	refractory	refractory	JJ
cord-015021-pol2qm74	7596	15	state	state	NN
cord-015021-pol2qm74	7596	16	to	to	IN
cord-015021-pol2qm74	7596	17	a	a	DT
cord-015021-pol2qm74	7596	18	lethal	lethal	JJ
cord-015021-pol2qm74	7596	19	dose	dose	NN
cord-015021-pol2qm74	7596	20	of	of	IN
cord-015021-pol2qm74	7596	21	Gram	Gram	NNP
cord-015021-pol2qm74	7596	22	negative	negative	JJ
cord-015021-pol2qm74	7596	23	bacterial	bacterial	JJ
cord-015021-pol2qm74	7596	24	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7596	25	concomitantly	concomitantly	RB
cord-015021-pol2qm74	7596	26	display	display	NN
cord-015021-pol2qm74	7596	27	increased	increase	VBN
cord-015021-pol2qm74	7596	28	resistance	resistance	NN
cord-015021-pol2qm74	7596	29	to	to	IN
cord-015021-pol2qm74	7596	30	a	a	DT
cord-015021-pol2qm74	7596	31	live	live	JJ
cord-015021-pol2qm74	7596	32	bacterial	bacterial	JJ
cord-015021-pol2qm74	7596	33	challenge	challenge	NN
cord-015021-pol2qm74	7596	34	.	.	.
cord-015021-pol2qm74	7597	1	Thus	thus	RB
cord-015021-pol2qm74	7597	2	,	,	,
cord-015021-pol2qm74	7597	3	both	both	DT
cord-015021-pol2qm74	7597	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7597	5	tolerance	tolerance	NN
cord-015021-pol2qm74	7597	6	and	and	CC
cord-015021-pol2qm74	7597	7	nonspeciflc	nonspeciflc	NN
cord-015021-pol2qm74	7597	8	resistance	resistance	NN
cord-015021-pol2qm74	7597	9	to	to	IN
cord-015021-pol2qm74	7597	10	infection	infection	NN
cord-015021-pol2qm74	7597	11	can	can	MD
cord-015021-pol2qm74	7597	12	be	be	VB
cord-015021-pol2qm74	7597	13	manifested	manifest	VBN
cord-015021-pol2qm74	7597	14	simultaneously	simultaneously	RB
cord-015021-pol2qm74	7597	15	.	.	.
cord-015021-pol2qm74	7598	1	Also	also	RB
cord-015021-pol2qm74	7598	2	,	,	,
cord-015021-pol2qm74	7598	3	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	7598	4	doses	dose	NNS
cord-015021-pol2qm74	7598	5	of	of	IN
cord-015021-pol2qm74	7598	6	MLA	MLA	NNP
cord-015021-pol2qm74	7598	7	do	do	VBP
cord-015021-pol2qm74	7598	8	not	not	RB
cord-015021-pol2qm74	7598	9	interfere	interfere	VB
cord-015021-pol2qm74	7598	10	with	with	IN
cord-015021-pol2qm74	7598	11	other	other	JJ
cord-015021-pol2qm74	7598	12	therapies	therapy	NNS
cord-015021-pol2qm74	7598	13	given	give	VBN
cord-015021-pol2qm74	7598	14	subsequently	subsequently	RB
cord-015021-pol2qm74	7598	15	;	;	:
cord-015021-pol2qm74	7598	16	an	an	DT
cord-015021-pol2qm74	7598	17	additive	additive	NN
cord-015021-pol2qm74	7598	18	or	or	CC
cord-015021-pol2qm74	7598	19	a	a	DT
cord-015021-pol2qm74	7598	20	synergistic	synergistic	JJ
cord-015021-pol2qm74	7598	21	protective	protective	JJ
cord-015021-pol2qm74	7598	22	effect	effect	NN
cord-015021-pol2qm74	7598	23	can	can	MD
cord-015021-pol2qm74	7598	24	be	be	VB
cord-015021-pol2qm74	7598	25	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7598	26	with	with	IN
cord-015021-pol2qm74	7598	27	certain	certain	JJ
cord-015021-pol2qm74	7598	28	combinatorial	combinatorial	JJ
cord-015021-pol2qm74	7598	29	treatment	treatment	NN
cord-015021-pol2qm74	7598	30	regimens	regimen	NNS
cord-015021-pol2qm74	7598	31	,	,	,
cord-015021-pol2qm74	7598	32	such	such	JJ
cord-015021-pol2qm74	7598	33	as	as	IN
cord-015021-pol2qm74	7598	34	MLA	MLA	NNP
cord-015021-pol2qm74	7598	35	followed	follow	VBD
cord-015021-pol2qm74	7598	36	by	by	IN
cord-015021-pol2qm74	7598	37	antiendotoxin	antiendotoxin	NNP
cord-015021-pol2qm74	7598	38	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7598	39	antibodies	antibody	NNS
cord-015021-pol2qm74	7598	40	.	.	.
cord-015021-pol2qm74	7599	1	The	the	DT
cord-015021-pol2qm74	7599	2	preclinical	preclinical	JJ
cord-015021-pol2qm74	7599	3	studies	study	NNS
cord-015021-pol2qm74	7599	4	were	be	VBD
cord-015021-pol2qm74	7599	5	extended	extend	VBN
cord-015021-pol2qm74	7599	6	to	to	IN
cord-015021-pol2qm74	7599	7	human	human	JJ
cord-015021-pol2qm74	7599	8	trials	trial	NNS
cord-015021-pol2qm74	7599	9	wherein	wherein	WRB
cord-015021-pol2qm74	7599	10	the	the	DT
cord-015021-pol2qm74	7599	11	safety	safety	NN
cord-015021-pol2qm74	7599	12	of	of	IN
cord-015021-pol2qm74	7599	13	agonistic	agonistic	JJ
cord-015021-pol2qm74	7599	14	doses	dose	NNS
cord-015021-pol2qm74	7599	15	of	of	IN
cord-015021-pol2qm74	7599	16	MLA	MLA	NNP
cord-015021-pol2qm74	7599	17	was	be	VBD
cord-015021-pol2qm74	7599	18	verified	verify	VBN
cord-015021-pol2qm74	7599	19	.	.	.
cord-015021-pol2qm74	7600	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	7600	2	,	,	,
cord-015021-pol2qm74	7600	3	when	when	WRB
cord-015021-pol2qm74	7600	4	MLA	MLA	NNP
cord-015021-pol2qm74	7600	5	was	be	VBD
cord-015021-pol2qm74	7600	6	administered	administer	VBN
cord-015021-pol2qm74	7600	7	to	to	IN
cord-015021-pol2qm74	7600	8	human	human	JJ
cord-015021-pol2qm74	7600	9	volunteers	volunteer	NNS
cord-015021-pol2qm74	7600	10	24	24	CD
cord-015021-pol2qm74	7600	11	hr	hr	NN
cord-015021-pol2qm74	7600	12	before	before	IN
cord-015021-pol2qm74	7600	13	challenge	challenge	NN
cord-015021-pol2qm74	7600	14	with	with	IN
cord-015021-pol2qm74	7600	15	a	a	DT
cord-015021-pol2qm74	7600	16	pharmacologically	pharmacologically	RB
cord-015021-pol2qm74	7600	17	active	active	JJ
cord-015021-pol2qm74	7600	18	dose	dose	NN
cord-015021-pol2qm74	7600	19	of	of	IN
cord-015021-pol2qm74	7600	20	reference	reference	NN
cord-015021-pol2qm74	7600	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7600	22	,	,	,
cord-015021-pol2qm74	7600	23	febrile	febrile	JJ
cord-015021-pol2qm74	7600	24	,	,	,
cord-015021-pol2qm74	7600	25	cardiac	cardiac	NN
cord-015021-pol2qm74	7600	26	,	,	,
cord-015021-pol2qm74	7600	27	TNF	TNF	NNP
cord-015021-pol2qm74	7600	28	,	,	,
cord-015021-pol2qm74	7600	29	IL-6	IL-6	NNP
cord-015021-pol2qm74	7600	30	,	,	,
cord-015021-pol2qm74	7600	31	and	and	CC
cord-015021-pol2qm74	7600	32	IL-8	il-8	NN
cord-015021-pol2qm74	7600	33	responses	response	NNS
cord-015021-pol2qm74	7600	34	were	be	VBD
cord-015021-pol2qm74	7600	35	all	all	DT
cord-015021-pol2qm74	7600	36	decreased	decrease	VBN
cord-015021-pol2qm74	7600	37	significantly	significantly	RB
cord-015021-pol2qm74	7600	38	as	as	IN
cord-015021-pol2qm74	7600	39	compared	compare	VBN
cord-015021-pol2qm74	7600	40	with	with	IN
cord-015021-pol2qm74	7600	41	the	the	DT
cord-015021-pol2qm74	7600	42	responses	response	NNS
cord-015021-pol2qm74	7600	43	of	of	IN
cord-015021-pol2qm74	7600	44	subjects	subject	NNS
cord-015021-pol2qm74	7600	45	pretreated	pretreate	VBN
cord-015021-pol2qm74	7600	46	with	with	IN
cord-015021-pol2qm74	7600	47	a	a	DT
cord-015021-pol2qm74	7600	48	control	control	NN
cord-015021-pol2qm74	7600	49	solution	solution	NN
cord-015021-pol2qm74	7600	50	and	and	CC
cord-015021-pol2qm74	7600	51	challenged	challenge	VBN
cord-015021-pol2qm74	7600	52	with	with	IN
cord-015021-pol2qm74	7600	53	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7600	54	.	.	.
cord-015021-pol2qm74	7601	1	Human	human	JJ
cord-015021-pol2qm74	7601	2	trials	trial	NNS
cord-015021-pol2qm74	7601	3	with	with	IN
cord-015021-pol2qm74	7601	4	MLA	MLA	NNP
cord-015021-pol2qm74	7601	5	are	be	VBP
cord-015021-pol2qm74	7601	6	being	be	VBG
cord-015021-pol2qm74	7601	7	extended	extend	VBN
cord-015021-pol2qm74	7601	8	into	into	IN
cord-015021-pol2qm74	7601	9	patient	patient	JJ
cord-015021-pol2qm74	7601	10	cohorts	cohort	NNS
cord-015021-pol2qm74	7601	11	which	which	WDT
cord-015021-pol2qm74	7601	12	have	have	VBP
cord-015021-pol2qm74	7601	13	high	high	JJ
cord-015021-pol2qm74	7601	14	probabilities	probability	NNS
cord-015021-pol2qm74	7601	15	of	of	IN
cord-015021-pol2qm74	7601	16	developing	develop	VBG
cord-015021-pol2qm74	7601	17	septic	septic	JJ
cord-015021-pol2qm74	7601	18	shock	shock	NN
cord-015021-pol2qm74	7601	19	;	;	:
cord-015021-pol2qm74	7601	20	this	this	DT
cord-015021-pol2qm74	7601	21	will	will	MD
cord-015021-pol2qm74	7601	22	expand	expand	VB
cord-015021-pol2qm74	7601	23	the	the	DT
cord-015021-pol2qm74	7601	24	safety	safety	NN
cord-015021-pol2qm74	7601	25	base	base	NN
cord-015021-pol2qm74	7601	26	and	and	CC
cord-015021-pol2qm74	7601	27	establish	establish	VB
cord-015021-pol2qm74	7601	28	clinical	clinical	JJ
cord-015021-pol2qm74	7601	29	efficacy	efficacy	NN
cord-015021-pol2qm74	7601	30	for	for	IN
cord-015021-pol2qm74	7601	31	MPL	MPL	NNP
cord-015021-pol2qm74	7601	32	®	®	POS
cord-015021-pol2qm74	7601	33	-immunostimulant	-immunostimulant	CD
cord-015021-pol2qm74	7601	34	.	.	.
cord-015021-pol2qm74	7602	1	A	a	DT
cord-015021-pol2qm74	7602	2	considerable	considerable	JJ
cord-015021-pol2qm74	7602	3	body	body	NN
cord-015021-pol2qm74	7602	4	of	of	IN
cord-015021-pol2qm74	7602	5	in	in	FW
cord-015021-pol2qm74	7602	6	vitro	vitro	FW
cord-015021-pol2qm74	7602	7	evidence	evidence	NN
cord-015021-pol2qm74	7602	8	supports	support	VBZ
cord-015021-pol2qm74	7602	9	the	the	DT
cord-015021-pol2qm74	7602	10	concept	concept	NN
cord-015021-pol2qm74	7602	11	that	that	IN
cord-015021-pol2qm74	7602	12	the	the	DT
cord-015021-pol2qm74	7602	13	effects	effect	NNS
cord-015021-pol2qm74	7602	14	of	of	IN
cord-015021-pol2qm74	7602	15	LPS	lp	NNS
cord-015021-pol2qm74	7602	16	on	on	IN
cord-015021-pol2qm74	7602	17	cells	cell	NNS
cord-015021-pol2qm74	7602	18	of	of	IN
cord-015021-pol2qm74	7602	19	the	the	DT
cord-015021-pol2qm74	7602	20	immune	immune	JJ
cord-015021-pol2qm74	7602	21	/	/	SYM
cord-015021-pol2qm74	7602	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7602	23	systems	system	NNS
cord-015021-pol2qm74	7602	24	are	be	VBP
cord-015021-pol2qm74	7602	25	controlled	control	VBN
cord-015021-pol2qm74	7602	26	by	by	IN
cord-015021-pol2qm74	7602	27	interactions	interaction	NNS
cord-015021-pol2qm74	7602	28	of	of	IN
cord-015021-pol2qm74	7602	29	LPS	LPS	NNP
cord-015021-pol2qm74	7602	30	with	with	IN
cord-015021-pol2qm74	7602	31	CD14	CD14	NNP
cord-015021-pol2qm74	7602	32	.	.	.
cord-015021-pol2qm74	7603	1	To	to	TO
cord-015021-pol2qm74	7603	2	evaluate	evaluate	VB
cord-015021-pol2qm74	7603	3	if	if	IN
cord-015021-pol2qm74	7603	4	blocking	block	VBG
cord-015021-pol2qm74	7603	5	LPS	LPS	NNP
cord-015021-pol2qm74	7603	6	-	-	HYPH
cord-015021-pol2qm74	7603	7	CD14	CD14	NNP
cord-015021-pol2qm74	7603	8	interactions	interaction	NNS
cord-015021-pol2qm74	7603	9	has	have	VBZ
cord-015021-pol2qm74	7603	10	potential	potential	JJ
cord-015021-pol2qm74	7603	11	as	as	IN
cord-015021-pol2qm74	7603	12	a	a	DT
cord-015021-pol2qm74	7603	13	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7603	14	in	in	IN
cord-015021-pol2qm74	7603	15	septic	septic	JJ
cord-015021-pol2qm74	7603	16	shock	shock	NN
cord-015021-pol2qm74	7603	17	we	-PRON-	PRP
cord-015021-pol2qm74	7603	18	have	have	VBP
cord-015021-pol2qm74	7603	19	evaluated	evaluate	VBN
cord-015021-pol2qm74	7603	20	the	the	DT
cord-015021-pol2qm74	7603	21	effect	effect	NN
cord-015021-pol2qm74	7603	22	of	of	IN
cord-015021-pol2qm74	7603	23	anti	anti	JJ
cord-015021-pol2qm74	7603	24	-	-	JJ
cord-015021-pol2qm74	7603	25	CDI4	cdi4	JJ
cord-015021-pol2qm74	7603	26	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7603	27	antibody	antibody	NN
cord-015021-pol2qm74	7603	28	(	(	-LRB-
cord-015021-pol2qm74	7603	29	mAb	mAb	NNS
cord-015021-pol2qm74	7603	30	)	)	-RRB-
cord-015021-pol2qm74	7603	31	on	on	IN
cord-015021-pol2qm74	7603	32	LPS	LPS	NNP
cord-015021-pol2qm74	7603	33	-	-	HYPH
cord-015021-pol2qm74	7603	34	induced	induce	VBN
cord-015021-pol2qm74	7603	35	cytokine	cytokine	NN
cord-015021-pol2qm74	7603	36	production	production	NN
cord-015021-pol2qm74	7603	37	and	and	CC
cord-015021-pol2qm74	7603	38	physiologic	physiologic	JJ
cord-015021-pol2qm74	7603	39	changes	change	NNS
cord-015021-pol2qm74	7603	40	in	in	IN
cord-015021-pol2qm74	7603	41	an	an	DT
cord-015021-pol2qm74	7603	42	experimental	experimental	JJ
cord-015021-pol2qm74	7603	43	model	model	NN
cord-015021-pol2qm74	7603	44	of	of	IN
cord-015021-pol2qm74	7603	45	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7603	46	shock	shock	NN
cord-015021-pol2qm74	7603	47	performed	perform	VBN
cord-015021-pol2qm74	7603	48	in	in	IN
cord-015021-pol2qm74	7603	49	cynomolgus	cynomolgus	JJ
cord-015021-pol2qm74	7603	50	monkeys	monkey	NNS
cord-015021-pol2qm74	7603	51	.	.	.
cord-015021-pol2qm74	7604	1	A	a	DT
cord-015021-pol2qm74	7604	2	novel	novel	JJ
cord-015021-pol2qm74	7604	3	model	model	NN
cord-015021-pol2qm74	7604	4	has	have	VBZ
cord-015021-pol2qm74	7604	5	been	be	VBN
cord-015021-pol2qm74	7604	6	established	establish	VBN
cord-015021-pol2qm74	7604	7	where	where	WRB
cord-015021-pol2qm74	7604	8	animals	animal	NNS
cord-015021-pol2qm74	7604	9	were	be	VBD
cord-015021-pol2qm74	7604	10	treated	treat	VBN
cord-015021-pol2qm74	7604	11	with	with	IN
cord-015021-pol2qm74	7604	12	interferongamma	interferongamma	NNP
cord-015021-pol2qm74	7604	13	for	for	IN
cord-015021-pol2qm74	7604	14	three	three	CD
cord-015021-pol2qm74	7604	15	days	day	NNS
cord-015021-pol2qm74	7604	16	prior	prior	RB
cord-015021-pol2qm74	7604	17	to	to	IN
cord-015021-pol2qm74	7604	18	infusion	infusion	NN
cord-015021-pol2qm74	7604	19	of	of	IN
cord-015021-pol2qm74	7604	20	highly	highly	RB
cord-015021-pol2qm74	7604	21	purified	purify	VBN
cord-015021-pol2qm74	7604	22	LPS	lp	NNS
cord-015021-pol2qm74	7604	23	over	over	RP
cord-015021-pol2qm74	7604	24	an	an	DT
cord-015021-pol2qm74	7604	25	eight	eight	CD
cord-015021-pol2qm74	7604	26	hour	hour	NN
cord-015021-pol2qm74	7604	27	period	period	NN
cord-015021-pol2qm74	7604	28	.	.	.
cord-015021-pol2qm74	7605	1	In	in	IN
cord-015021-pol2qm74	7605	2	this	this	DT
cord-015021-pol2qm74	7605	3	model	model	NN
cord-015021-pol2qm74	7605	4	LPS	LPS	NNP
cord-015021-pol2qm74	7605	5	challenge	challenge	NN
cord-015021-pol2qm74	7605	6	resulted	result	VBD
cord-015021-pol2qm74	7605	7	in	in	IN
cord-015021-pol2qm74	7605	8	marked	marked	JJ
cord-015021-pol2qm74	7605	9	release	release	NN
cord-015021-pol2qm74	7605	10	of	of	IN
cord-015021-pol2qm74	7605	11	eytokines	eytokine	NNS
cord-015021-pol2qm74	7605	12	in	in	IN
cord-015021-pol2qm74	7605	13	the	the	DT
cord-015021-pol2qm74	7605	14	blood	blood	NN
cord-015021-pol2qm74	7605	15	,	,	,
cord-015021-pol2qm74	7605	16	substantial	substantial	JJ
cord-015021-pol2qm74	7605	17	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	7605	18	changes	change	NNS
cord-015021-pol2qm74	7605	19	,	,	,
cord-015021-pol2qm74	7605	20	release	release	NN
cord-015021-pol2qm74	7605	21	of	of	IN
cord-015021-pol2qm74	7605	22	liver	liver	NN
cord-015021-pol2qm74	7605	23	enzymes	enzyme	NNS
cord-015021-pol2qm74	7605	24	and	and	CC
cord-015021-pol2qm74	7605	25	alteration	alteration	NN
cord-015021-pol2qm74	7605	26	in	in	IN
cord-015021-pol2qm74	7605	27	lung	lung	NN
cord-015021-pol2qm74	7605	28	permeability	permeability	NN
cord-015021-pol2qm74	7605	29	observed	observe	VBD
cord-015021-pol2qm74	7605	30	over	over	IN
cord-015021-pol2qm74	7605	31	a	a	DT
cord-015021-pol2qm74	7605	32	24	24	CD
cord-015021-pol2qm74	7605	33	hour	hour	NN
cord-015021-pol2qm74	7605	34	period	period	NN
cord-015021-pol2qm74	7605	35	.	.	.
cord-015021-pol2qm74	7606	1	To	to	TO
cord-015021-pol2qm74	7606	2	evaluate	evaluate	VB
cord-015021-pol2qm74	7606	3	the	the	DT
cord-015021-pol2qm74	7606	4	effect	effect	NN
cord-015021-pol2qm74	7606	5	of	of	IN
cord-015021-pol2qm74	7606	6	treatment	treatment	NN
cord-015021-pol2qm74	7606	7	with	with	IN
cord-015021-pol2qm74	7606	8	anti	anti	JJ
cord-015021-pol2qm74	7606	9	-	-	JJ
cord-015021-pol2qm74	7606	10	CD14	cd14	JJ
cord-015021-pol2qm74	7606	11	mAb	mAb	NNS
cord-015021-pol2qm74	7606	12	,	,	,
cord-015021-pol2qm74	7606	13	animals	animal	NNS
cord-015021-pol2qm74	7606	14	were	be	VBD
cord-015021-pol2qm74	7606	15	given	give	VBN
cord-015021-pol2qm74	7606	16	either	either	CC
cord-015021-pol2qm74	7606	17	nothing	nothing	NN
cord-015021-pol2qm74	7606	18	,	,	,
cord-015021-pol2qm74	7606	19	an	an	DT
cord-015021-pol2qm74	7606	20	isotype	isotype	NN
cord-015021-pol2qm74	7606	21	control	control	NN
cord-015021-pol2qm74	7606	22	or	or	CC
cord-015021-pol2qm74	7606	23	anti	anti	JJ
cord-015021-pol2qm74	7606	24	-	-	JJ
cord-015021-pol2qm74	7606	25	CD14	cd14	JJ
cord-015021-pol2qm74	7606	26	mAb	mAb	NNS
cord-015021-pol2qm74	7606	27	(	(	-LRB-
cord-015021-pol2qm74	7606	28	5mg	5mg	NNP
cord-015021-pol2qm74	7606	29	/	/	SYM
cord-015021-pol2qm74	7606	30	kg	kg	NN
cord-015021-pol2qm74	7606	31	)	)	-RRB-
cord-015021-pol2qm74	7606	32	30	30	CD
cord-015021-pol2qm74	7606	33	rains	rain	NNS
cord-015021-pol2qm74	7606	34	,	,	,
cord-015021-pol2qm74	7606	35	prior	prior	RB
cord-015021-pol2qm74	7606	36	to	to	IN
cord-015021-pol2qm74	7606	37	the	the	DT
cord-015021-pol2qm74	7606	38	beginning	beginning	NN
cord-015021-pol2qm74	7606	39	of	of	IN
cord-015021-pol2qm74	7606	40	the	the	DT
cord-015021-pol2qm74	7606	41	LPS	LPS	NNP
cord-015021-pol2qm74	7606	42	infusion	infusion	NN
cord-015021-pol2qm74	7606	43	.	.	.
cord-015021-pol2qm74	7607	1	Evaluation	evaluation	NN
cord-015021-pol2qm74	7607	2	of	of	IN
cord-015021-pol2qm74	7607	3	physiologic	physiologic	JJ
cord-015021-pol2qm74	7607	4	changes	change	NNS
cord-015021-pol2qm74	7607	5	including	include	VBG
cord-015021-pol2qm74	7607	6	mean	mean	VBP
cord-015021-pol2qm74	7607	7	arterial	arterial	JJ
cord-015021-pol2qm74	7607	8	blood	blood	NN
cord-015021-pol2qm74	7607	9	pressure	pressure	NN
cord-015021-pol2qm74	7607	10	and	and	CC
cord-015021-pol2qm74	7607	11	cardiac	cardiac	JJ
cord-015021-pol2qm74	7607	12	output	output	NN
cord-015021-pol2qm74	7607	13	,	,	,
cord-015021-pol2qm74	7607	14	quantitative	quantitative	JJ
cord-015021-pol2qm74	7607	15	analysis	analysis	NN
cord-015021-pol2qm74	7607	16	of	of	IN
cord-015021-pol2qm74	7607	17	eytoldne	eytoldne	JJ
cord-015021-pol2qm74	7607	18	levels	level	NNS
cord-015021-pol2qm74	7607	19	including	include	VBG
cord-015021-pol2qm74	7607	20	TNFct	TNFct	NNP
cord-015021-pol2qm74	7607	21	,	,	,
cord-015021-pol2qm74	7607	22	IL-113,1I,-6	IL-113,1I,-6	NNP
cord-015021-pol2qm74	7607	23	,	,	,
cord-015021-pol2qm74	7607	24	IL-8	IL-8	NNP
cord-015021-pol2qm74	7607	25	and	and	CC
cord-015021-pol2qm74	7607	26	IL-10	IL-10	NNP
cord-015021-pol2qm74	7607	27	,	,	,
cord-015021-pol2qm74	7607	28	and	and	CC
cord-015021-pol2qm74	7607	29	liver	liver	NN
cord-015021-pol2qm74	7607	30	enzymes	enzyme	NNS
cord-015021-pol2qm74	7607	31	during	during	IN
cord-015021-pol2qm74	7607	32	a	a	DT
cord-015021-pol2qm74	7607	33	24	24	CD
cord-015021-pol2qm74	7607	34	hour	hour	NN
cord-015021-pol2qm74	7607	35	period	period	NN
cord-015021-pol2qm74	7607	36	revealed	reveal	VBD
cord-015021-pol2qm74	7607	37	that	that	IN
cord-015021-pol2qm74	7607	38	treatment	treatment	NN
cord-015021-pol2qm74	7607	39	with	with	IN
cord-015021-pol2qm74	7607	40	anti	anti	JJ
cord-015021-pol2qm74	7607	41	-	-	JJ
cord-015021-pol2qm74	7607	42	CD14	cd14	JJ
cord-015021-pol2qm74	7607	43	mAb	mAb	NNS
cord-015021-pol2qm74	7607	44	markedly	markedly	RB
cord-015021-pol2qm74	7607	45	attenuated	attenuate	VBD
cord-015021-pol2qm74	7607	46	all	all	DT
cord-015021-pol2qm74	7607	47	parameters	parameter	NNS
cord-015021-pol2qm74	7607	48	of	of	IN
cord-015021-pol2qm74	7607	49	injury	injury	NN
cord-015021-pol2qm74	7607	50	including	include	VBG
cord-015021-pol2qm74	7607	51	decreased	decrease	VBD
cord-015021-pol2qm74	7607	52	mean	mean	JJ
cord-015021-pol2qm74	7607	53	arterial	arterial	JJ
cord-015021-pol2qm74	7607	54	blood	blood	NN
cord-015021-pol2qm74	7607	55	pressure	pressure	NN
cord-015021-pol2qm74	7607	56	,	,	,
cord-015021-pol2qm74	7607	57	increased	increase	VBN
cord-015021-pol2qm74	7607	58	cytnkine	cytnkine	NN
cord-015021-pol2qm74	7607	59	levels	level	NNS
cord-015021-pol2qm74	7607	60	and	and	CC
cord-015021-pol2qm74	7607	61	the	the	DT
cord-015021-pol2qm74	7607	62	release	release	NN
cord-015021-pol2qm74	7607	63	of	of	IN
cord-015021-pol2qm74	7607	64	liver	liver	NN
cord-015021-pol2qm74	7607	65	enzymes	enzyme	NNS
cord-015021-pol2qm74	7607	66	observed	observe	VBN
cord-015021-pol2qm74	7607	67	in	in	IN
cord-015021-pol2qm74	7607	68	animals	animal	NNS
cord-015021-pol2qm74	7607	69	given	give	VBN
cord-015021-pol2qm74	7607	70	the	the	DT
cord-015021-pol2qm74	7607	71	isotype	isotype	NN
cord-015021-pol2qm74	7607	72	control	control	NN
cord-015021-pol2qm74	7607	73	mAb	mAb	NNS
cord-015021-pol2qm74	7607	74	or	or	CC
cord-015021-pol2qm74	7607	75	those	those	DT
cord-015021-pol2qm74	7607	76	not	not	RB
cord-015021-pol2qm74	7607	77	treated	treat	VBN
cord-015021-pol2qm74	7607	78	.	.	.
cord-015021-pol2qm74	7608	1	Administration	Administration	NNP
cord-015021-pol2qm74	7608	2	of	of	IN
cord-015021-pol2qm74	7608	3	anti	anti	JJ
cord-015021-pol2qm74	7608	4	-	-	JJ
cord-015021-pol2qm74	7608	5	CD14	cd14	JJ
cord-015021-pol2qm74	7608	6	mAb	mAb	NNS
cord-015021-pol2qm74	7608	7	to	to	IN
cord-015021-pol2qm74	7608	8	interferon	interferon	NN
cord-015021-pol2qm74	7608	9	-	-	HYPH
cord-015021-pol2qm74	7608	10	gamma	gamma	NN
cord-015021-pol2qm74	7608	11	treated	treat	VBN
cord-015021-pol2qm74	7608	12	animals	animal	NNS
cord-015021-pol2qm74	7608	13	NOT	not	RB
cord-015021-pol2qm74	7608	14	challenged	challenge	VBN
cord-015021-pol2qm74	7608	15	with	with	IN
cord-015021-pol2qm74	7608	16	LPS	LPS	NNP
cord-015021-pol2qm74	7608	17	did	do	VBD
cord-015021-pol2qm74	7608	18	not	not	RB
cord-015021-pol2qm74	7608	19	induce	induce	VB
cord-015021-pol2qm74	7608	20	any	any	DT
cord-015021-pol2qm74	7608	21	detectable	detectable	JJ
cord-015021-pol2qm74	7608	22	physiologic	physiologic	JJ
cord-015021-pol2qm74	7608	23	changes	change	NNS
cord-015021-pol2qm74	7608	24	or	or	CC
cord-015021-pol2qm74	7608	25	increases	increase	NNS
cord-015021-pol2qm74	7608	26	in	in	IN
cord-015021-pol2qm74	7608	27	cytoldnes	cytoldne	NNS
cord-015021-pol2qm74	7608	28	.	.	.
cord-015021-pol2qm74	7609	1	These	these	DT
cord-015021-pol2qm74	7609	2	studies	study	NNS
cord-015021-pol2qm74	7609	3	suggest	suggest	VBP
cord-015021-pol2qm74	7609	4	that	that	IN
cord-015021-pol2qm74	7609	5	strategies	strategy	NNS
cord-015021-pol2qm74	7609	6	to	to	TO
cord-015021-pol2qm74	7609	7	block	block	VB
cord-015021-pol2qm74	7609	8	LPS	LPS	NNP
cord-015021-pol2qm74	7609	9	-	-	HYPH
cord-015021-pol2qm74	7609	10	CD14	CD14	NNP
cord-015021-pol2qm74	7609	11	interactions	interaction	NNS
cord-015021-pol2qm74	7609	12	will	will	MD
cord-015021-pol2qm74	7609	13	have	have	VB
cord-015021-pol2qm74	7609	14	utility	utility	NN
cord-015021-pol2qm74	7609	15	in	in	IN
cord-015021-pol2qm74	7609	16	diseases	disease	NNS
cord-015021-pol2qm74	7609	17	such	such	JJ
cord-015021-pol2qm74	7609	18	as	as	IN
cord-015021-pol2qm74	7609	19	septic	septic	JJ
cord-015021-pol2qm74	7609	20	shock	shock	NN
cord-015021-pol2qm74	7609	21	or	or	CC
cord-015021-pol2qm74	7609	22	ARDS	ARDS	NNP
cord-015021-pol2qm74	7609	23	where	where	WRB
cord-015021-pol2qm74	7609	24	LPS	LPS	NNP
cord-015021-pol2qm74	7609	25	plays	play	VBZ
cord-015021-pol2qm74	7609	26	a	a	DT
cord-015021-pol2qm74	7609	27	central	central	JJ
cord-015021-pol2qm74	7609	28	role	role	NN
cord-015021-pol2qm74	7609	29	in	in	IN
cord-015021-pol2qm74	7609	30	initiating	initiate	VBG
cord-015021-pol2qm74	7609	31	injury	injury	NN
cord-015021-pol2qm74	7609	32	.	.	.
cord-015021-pol2qm74	7610	1	Preclinical	Preclinical	NNP
cord-015021-pol2qm74	7610	2	Studies	Studies	NNPS
cord-015021-pol2qm74	7610	3	with	with	IN
cord-015021-pol2qm74	7610	4	Recombinant	Recombinant	NNP
cord-015021-pol2qm74	7610	5	Bactericidal	Bactericidal	NNP
cord-015021-pol2qm74	7610	6	/	/	SYM
cord-015021-pol2qm74	7610	7	Permeability	Permeability	NNP
cord-015021-pol2qm74	7610	8	Increasing	increase	VBG
cord-015021-pol2qm74	7610	9	Proteins	protein	NNS
cord-015021-pol2qm74	7610	10	(	(	-LRB-
cord-015021-pol2qm74	7610	11	rBPI	rbpi	NN
cord-015021-pol2qm74	7610	12	and	and	CC
cord-015021-pol2qm74	7610	13	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7610	14	)	)	-RRB-
cord-015021-pol2qm74	7610	15	.	.	.
cord-015021-pol2qm74	7611	1	P.W.	P.W.	NNP
cord-015021-pol2qm74	7611	2	"	"	``
cord-015021-pol2qm74	7611	3	Frown	Frown	NNP
cord-015021-pol2qm74	7611	4	,	,	,
cord-015021-pol2qm74	7611	5	Dept	Dept	NNP
cord-015021-pol2qm74	7611	6	.	.	NNP
cord-015021-pol2qm74	7611	7	of	of	IN
cord-015021-pol2qm74	7611	8	Preclinical	Preclinical	NNP
cord-015021-pol2qm74	7611	9	Science	Science	NNP
cord-015021-pol2qm74	7611	10	,	,	,
cord-015021-pol2qm74	7611	11	XOMA	XOMA	NNP
cord-015021-pol2qm74	7611	12	Corporation	Corporation	NNP
cord-015021-pol2qm74	7611	13	,	,	,
cord-015021-pol2qm74	7611	14	Berkeley	Berkeley	NNP
cord-015021-pol2qm74	7611	15	,	,	,
cord-015021-pol2qm74	7611	16	California	California	NNP
cord-015021-pol2qm74	7611	17	,	,	,
cord-015021-pol2qm74	7611	18	USA	USA	NNP
cord-015021-pol2qm74	7611	19	.	.	.
cord-015021-pol2qm74	7612	1	Bactericidal	bactericidal	JJ
cord-015021-pol2qm74	7612	2	/	/	SYM
cord-015021-pol2qm74	7612	3	permeability	permeability	NN
cord-015021-pol2qm74	7612	4	increasing	increase	VBG
cord-015021-pol2qm74	7612	5	protein	protein	NN
cord-015021-pol2qm74	7612	6	(	(	-LRB-
cord-015021-pol2qm74	7612	7	BPI	BPI	NNP
cord-015021-pol2qm74	7612	8	)	)	-RRB-
cord-015021-pol2qm74	7612	9	,	,	,
cord-015021-pol2qm74	7612	10	from	from	IN
cord-015021-pol2qm74	7612	11	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7612	12	,	,	,
cord-015021-pol2qm74	7612	13	binds	bind	VBZ
cord-015021-pol2qm74	7612	14	to	to	IN
cord-015021-pol2qm74	7612	15	and	and	CC
cord-015021-pol2qm74	7612	16	neutralizes	neutralize	VBZ
cord-015021-pol2qm74	7612	17	lipopolysaccharide	lipopolysaccharide	NN
cord-015021-pol2qm74	7612	18	(	(	-LRB-
cord-015021-pol2qm74	7612	19	LPS	LPS	NNP
cord-015021-pol2qm74	7612	20	)	)	-RRB-
cord-015021-pol2qm74	7612	21	;	;	:
cord-015021-pol2qm74	7612	22	it	-PRON-	PRP
cord-015021-pol2qm74	7612	23	also	also	RB
cord-015021-pol2qm74	7612	24	specifically	specifically	RB
cord-015021-pol2qm74	7612	25	kills	kill	VBZ
cord-015021-pol2qm74	7612	26	gram	gram	NN
cord-015021-pol2qm74	7612	27	-	-	HYPH
cord-015021-pol2qm74	7612	28	negative	negative	JJ
cord-015021-pol2qm74	7612	29	bacteria	bacteria	NNS
cord-015021-pol2qm74	7612	30	(	(	-LRB-
cord-015021-pol2qm74	7612	31	GNB	GNB	NNP
cord-015021-pol2qm74	7612	32	)	)	-RRB-
cord-015021-pol2qm74	7612	33	.	.	.
cord-015021-pol2qm74	7613	1	These	these	DT
cord-015021-pol2qm74	7613	2	properties	property	NNS
cord-015021-pol2qm74	7613	3	,	,	,
cord-015021-pol2qm74	7613	4	which	which	WDT
cord-015021-pol2qm74	7613	5	reside	reside	VBP
cord-015021-pol2qm74	7613	6	in	in	IN
cord-015021-pol2qm74	7613	7	the	the	DT
cord-015021-pol2qm74	7613	8	N	n	CD
cord-015021-pol2qm74	7613	9	-	-	HYPH
cord-015021-pol2qm74	7613	10	terminal	terminal	JJ
cord-015021-pol2qm74	7613	11	half	half	NN
cord-015021-pol2qm74	7613	12	of	of	IN
cord-015021-pol2qm74	7613	13	the	the	DT
cord-015021-pol2qm74	7613	14	molecule	molecule	NN
cord-015021-pol2qm74	7613	15	,	,	,
cord-015021-pol2qm74	7613	16	indicate	indicate	VBP
cord-015021-pol2qm74	7613	17	potential	potential	JJ
cord-015021-pol2qm74	7613	18	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7613	19	application	application	NN
cord-015021-pol2qm74	7613	20	in	in	IN
cord-015021-pol2qm74	7613	21	the	the	DT
cord-015021-pol2qm74	7613	22	treatment	treatment	NN
cord-015021-pol2qm74	7613	23	of	of	IN
cord-015021-pol2qm74	7613	24	gram	gram	NN
cord-015021-pol2qm74	7613	25	-	-	HYPH
cord-015021-pol2qm74	7613	26	negative	negative	JJ
cord-015021-pol2qm74	7613	27	sepsis	sepsis	NN
cord-015021-pol2qm74	7613	28	.	.	.
cord-015021-pol2qm74	7614	1	The	the	DT
cord-015021-pol2qm74	7614	2	gene	gene	NN
cord-015021-pol2qm74	7614	3	for	for	IN
cord-015021-pol2qm74	7614	4	human	human	JJ
cord-015021-pol2qm74	7614	5	BPI	BPI	NNP
cord-015021-pol2qm74	7614	6	has	have	VBZ
cord-015021-pol2qm74	7614	7	been	be	VBN
cord-015021-pol2qm74	7614	8	cloned	clone	VBN
cord-015021-pol2qm74	7614	9	and	and	CC
cord-015021-pol2qm74	7614	10	recombinant	recombinant	JJ
cord-015021-pol2qm74	7614	11	holoprotein	holoprotein	NNP
cord-015021-pol2qm74	7614	12	(	(	-LRB-
cord-015021-pol2qm74	7614	13	rBPI	rBPI	NNP
cord-015021-pol2qm74	7614	14	)	)	-RRB-
cord-015021-pol2qm74	7614	15	and	and	CC
cord-015021-pol2qm74	7614	16	a	a	DT
cord-015021-pol2qm74	7614	17	23	23	CD
cord-015021-pol2qm74	7614	18	Kd	Kd	NNP
cord-015021-pol2qm74	7614	19	N	N	NNP
cord-015021-pol2qm74	7614	20	-	-	HYPH
cord-015021-pol2qm74	7614	21	terminal	terminal	NN
cord-015021-pol2qm74	7614	22	fragment	fragment	NN
cord-015021-pol2qm74	7614	23	(	(	-LRB-
cord-015021-pol2qm74	7614	24	rBPI;3	rbpi;3	NN
cord-015021-pol2qm74	7614	25	)	)	-RRB-
cord-015021-pol2qm74	7614	26	have	have	VBP
cord-015021-pol2qm74	7614	27	been	be	VBN
cord-015021-pol2qm74	7614	28	produced	produce	VBN
cord-015021-pol2qm74	7614	29	in	in	IN
cord-015021-pol2qm74	7614	30	sufficient	sufficient	JJ
cord-015021-pol2qm74	7614	31	quantities	quantity	NNS
cord-015021-pol2qm74	7614	32	for	for	IN
cord-015021-pol2qm74	7614	33	preclinical	preclinical	JJ
cord-015021-pol2qm74	7614	34	studies	study	NNS
cord-015021-pol2qm74	7614	35	.	.	.
cord-015021-pol2qm74	7615	1	Both	both	DT
cord-015021-pol2qm74	7615	2	rBPI	rbpi	NN
cord-015021-pol2qm74	7615	3	and	and	CC
cord-015021-pol2qm74	7615	4	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7615	5	bind	bind	VBP
cord-015021-pol2qm74	7615	6	to	to	IN
cord-015021-pol2qm74	7615	7	lipid	lipid	NN
cord-015021-pol2qm74	7615	8	A	a	NN
cord-015021-pol2qm74	7615	9	and	and	CC
cord-015021-pol2qm74	7615	10	neutralize	neutralize	VB
cord-015021-pol2qm74	7615	11	the	the	DT
cord-015021-pol2qm74	7615	12	biological	biological	JJ
cord-015021-pol2qm74	7615	13	activities	activity	NNS
cord-015021-pol2qm74	7615	14	of	of	IN
cord-015021-pol2qm74	7615	15	LPS	LPS	NNP
cord-015021-pol2qm74	7615	16	derived	derive	VBN
cord-015021-pol2qm74	7615	17	from	from	IN
cord-015021-pol2qm74	7615	18	a	a	DT
cord-015021-pol2qm74	7615	19	variety	variety	NN
cord-015021-pol2qm74	7615	20	of	of	IN
cord-015021-pol2qm74	7615	21	organisms	organism	NNS
cord-015021-pol2qm74	7615	22	,	,	,
cord-015021-pol2qm74	7615	23	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7615	24	has	have	VBZ
cord-015021-pol2qm74	7615	25	equivalent	equivalent	JJ
cord-015021-pol2qm74	7615	26	antibacterial	antibacterial	JJ
cord-015021-pol2qm74	7615	27	activity	activity	NN
cord-015021-pol2qm74	7615	28	to	to	IN
cord-015021-pol2qm74	7615	29	BPI	BPI	NNP
cord-015021-pol2qm74	7615	30	against	against	IN
cord-015021-pol2qm74	7615	31	rough	rough	JJ
cord-015021-pol2qm74	7615	32	GNB	GNB	NNP
cord-015021-pol2qm74	7615	33	but	but	CC
cord-015021-pol2qm74	7615	34	is	be	VBZ
cord-015021-pol2qm74	7615	35	up	up	RB
cord-015021-pol2qm74	7615	36	to	to	TO
cord-015021-pol2qm74	7615	37	30X	30X	NNS
cord-015021-pol2qm74	7615	38	more	more	RBR
cord-015021-pol2qm74	7615	39	potent	potent	JJ
cord-015021-pol2qm74	7615	40	than	than	IN
cord-015021-pol2qm74	7615	41	BPI	BPI	NNP
cord-015021-pol2qm74	7615	42	vs.	vs.	IN
cord-015021-pol2qm74	7615	43	serum	serum	NN
cord-015021-pol2qm74	7615	44	-	-	HYPH
cord-015021-pol2qm74	7615	45	resistant	resistant	JJ
cord-015021-pol2qm74	7615	46	and	and	CC
cord-015021-pol2qm74	7615	47	smooth	smooth	JJ
cord-015021-pol2qm74	7615	48	GNB	GNB	NNP
cord-015021-pol2qm74	7615	49	.	.	.
cord-015021-pol2qm74	7616	1	rBPI	rBPI	NNP
cord-015021-pol2qm74	7616	2	and	and	CC
cord-015021-pol2qm74	7616	3	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7616	4	compete	compete	VBP
cord-015021-pol2qm74	7616	5	with	with	IN
cord-015021-pol2qm74	7616	6	LPS	LPS	NNP
cord-015021-pol2qm74	7616	7	-	-	HYPH
cord-015021-pol2qm74	7616	8	binding	bind	VBG
cord-015021-pol2qm74	7616	9	protein	protein	NN
cord-015021-pol2qm74	7616	10	(	(	-LRB-
cord-015021-pol2qm74	7616	11	LBP	LBP	NNP
cord-015021-pol2qm74	7616	12	)	)	-RRB-
cord-015021-pol2qm74	7616	13	for	for	IN
cord-015021-pol2qm74	7616	14	binding	bind	VBG
cord-015021-pol2qm74	7616	15	to	to	IN
cord-015021-pol2qm74	7616	16	LPS	lp	NNS
cord-015021-pol2qm74	7616	17	under	under	IN
cord-015021-pol2qm74	7616	18	physiological	physiological	JJ
cord-015021-pol2qm74	7616	19	conditions	condition	NNS
cord-015021-pol2qm74	7616	20	.	.	.
cord-015021-pol2qm74	7617	1	Consequently	consequently	RB
cord-015021-pol2qm74	7617	2	,	,	,
cord-015021-pol2qm74	7617	3	both	both	CC
cord-015021-pol2qm74	7617	4	rBPI	rbpi	NN
cord-015021-pol2qm74	7617	5	and	and	CC
cord-015021-pol2qm74	7617	6	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7617	7	block	block	VB
cord-015021-pol2qm74	7617	8	the	the	DT
cord-015021-pol2qm74	7617	9	CD14-dependent	cd14-dependent	CD
cord-015021-pol2qm74	7617	10	LPSinduced	lpsinduced	JJ
cord-015021-pol2qm74	7617	11	synthesis	synthesis	NN
cord-015021-pol2qm74	7617	12	of	of	IN
cord-015021-pol2qm74	7617	13	the	the	DT
cord-015021-pol2qm74	7617	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	7617	15	TNF	TNF	NNP
cord-015021-pol2qm74	7617	16	,	,	,
cord-015021-pol2qm74	7617	17	IL-1	IL-1	NNP
cord-015021-pol2qm74	7617	18	,	,	,
cord-015021-pol2qm74	7617	19	EL-6	EL-6	NNP
cord-015021-pol2qm74	7617	20	and	and	CC
cord-015021-pol2qm74	7617	21	IL-8	IL-8	NNP
cord-015021-pol2qm74	7617	22	in	in	IN
cord-015021-pol2qm74	7617	23	vitro	vitro	FW
cord-015021-pol2qm74	7617	24	.	.	.
cord-015021-pol2qm74	7618	1	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7618	2	has	have	VBZ
cord-015021-pol2qm74	7618	3	also	also	RB
cord-015021-pol2qm74	7618	4	been	be	VBN
cord-015021-pol2qm74	7618	5	shown	show	VBN
cord-015021-pol2qm74	7618	6	to	to	TO
cord-015021-pol2qm74	7618	7	inhibit	inhibit	VB
cord-015021-pol2qm74	7618	8	the	the	DT
cord-015021-pol2qm74	7618	9	LPS	LPS	NNP
cord-015021-pol2qm74	7618	10	-	-	HYPH
cord-015021-pol2qm74	7618	11	induced	induce	VBN
cord-015021-pol2qm74	7618	12	synthesis	synthesis	NN
cord-015021-pol2qm74	7618	13	of	of	IN
cord-015021-pol2qm74	7618	14	reactive	reactive	JJ
cord-015021-pol2qm74	7618	15	02	02	CD
cord-015021-pol2qm74	7618	16	metabolites	metabolite	NNS
cord-015021-pol2qm74	7618	17	,	,	,
cord-015021-pol2qm74	7618	18	endothelial	endothelial	JJ
cord-015021-pol2qm74	7618	19	adhesion	adhesion	NN
cord-015021-pol2qm74	7618	20	molecules	molecule	NNS
cord-015021-pol2qm74	7618	21	and	and	CC
cord-015021-pol2qm74	7618	22	the	the	DT
cord-015021-pol2qm74	7618	23	procoagulant	procoagulant	NN
cord-015021-pol2qm74	7618	24	molecule	molecule	NN
cord-015021-pol2qm74	7618	25	tissue	tissue	NN
cord-015021-pol2qm74	7618	26	factor	factor	NN
cord-015021-pol2qm74	7618	27	.	.	.
cord-015021-pol2qm74	7619	1	In	in	IN
cord-015021-pol2qm74	7619	2	animals	animal	NNS
cord-015021-pol2qm74	7619	3	,	,	,
cord-015021-pol2qm74	7619	4	rBPI	rbpi	NN
cord-015021-pol2qm74	7619	5	has	have	VBZ
cord-015021-pol2qm74	7619	6	been	be	VBN
cord-015021-pol2qm74	7619	7	reported	report	VBN
cord-015021-pol2qm74	7619	8	to	to	TO
cord-015021-pol2qm74	7619	9	increase	increase	VB
cord-015021-pol2qm74	7619	10	survival	survival	NN
cord-015021-pol2qm74	7619	11	of	of	IN
cord-015021-pol2qm74	7619	12	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7619	13	-	-	HYPH
cord-015021-pol2qm74	7619	14	challenged	challenge	VBN
cord-015021-pol2qm74	7619	15	rats	rat	NNS
cord-015021-pol2qm74	7619	16	and	and	CC
cord-015021-pol2qm74	7619	17	mice	mouse	NNS
cord-015021-pol2qm74	7619	18	,	,	,
cord-015021-pol2qm74	7619	19	to	to	TO
cord-015021-pol2qm74	7619	20	inhibit	inhibit	VB
cord-015021-pol2qm74	7619	21	the	the	DT
cord-015021-pol2qm74	7619	22	dermal	dermal	JJ
cord-015021-pol2qm74	7619	23	Schwartzman	Schwartzman	NNP
cord-015021-pol2qm74	7619	24	reaction	reaction	NN
cord-015021-pol2qm74	7619	25	in	in	IN
cord-015021-pol2qm74	7619	26	rabbits	rabbit	NNS
cord-015021-pol2qm74	7619	27	and	and	CC
cord-015021-pol2qm74	7619	28	to	to	TO
cord-015021-pol2qm74	7619	29	increase	increase	VB
cord-015021-pol2qm74	7619	30	survival	survival	NN
cord-015021-pol2qm74	7619	31	of	of	IN
cord-015021-pol2qm74	7619	32	neutropenic	neutropenic	JJ
cord-015021-pol2qm74	7619	33	rats	rat	NNS
cord-015021-pol2qm74	7619	34	with	with	IN
cord-015021-pol2qm74	7619	35	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	7619	36	bacteremia	bacteremia	NN
cord-015021-pol2qm74	7619	37	,	,	,
cord-015021-pol2qm74	7619	38	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7619	39	increases	increase	VBZ
cord-015021-pol2qm74	7619	40	survival	survival	NN
cord-015021-pol2qm74	7619	41	and	and	CC
cord-015021-pol2qm74	7619	42	decreases	decrease	VBZ
cord-015021-pol2qm74	7619	43	cytokine	cytokine	NN
cord-015021-pol2qm74	7619	44	production	production	NN
cord-015021-pol2qm74	7619	45	in	in	IN
cord-015021-pol2qm74	7619	46	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7619	47	challenged	challenge	VBD
cord-015021-pol2qm74	7619	48	mice	mouse	NNS
cord-015021-pol2qm74	7619	49	and	and	CC
cord-015021-pol2qm74	7619	50	rats	rat	NNS
cord-015021-pol2qm74	7619	51	.	.	.
cord-015021-pol2qm74	7620	1	It	-PRON-	PRP
cord-015021-pol2qm74	7620	2	normalizes	normalize	VBZ
cord-015021-pol2qm74	7620	3	LPS	LPS	NNP
cord-015021-pol2qm74	7620	4	-	-	HYPH
cord-015021-pol2qm74	7620	5	induced	induce	VBN
cord-015021-pol2qm74	7620	6	changes	change	NNS
cord-015021-pol2qm74	7620	7	in	in	IN
cord-015021-pol2qm74	7620	8	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	7620	9	,	,	,
cord-015021-pol2qm74	7620	10	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7620	11	and/or	and/or	CC
cord-015021-pol2qm74	7620	12	metabolic	metabolic	JJ
cord-015021-pol2qm74	7620	13	parameters	parameter	NNS
cord-015021-pol2qm74	7620	14	in	in	IN
cord-015021-pol2qm74	7620	15	LPS	LPS	NNP
cord-015021-pol2qm74	7620	16	-	-	HYPH
cord-015021-pol2qm74	7620	17	induced	induce	VBN
cord-015021-pol2qm74	7620	18	rats	rat	NNS
cord-015021-pol2qm74	7620	19	,	,	,
cord-015021-pol2qm74	7620	20	rabbits	rabbit	NNS
cord-015021-pol2qm74	7620	21	and	and	CC
cord-015021-pol2qm74	7620	22	pigs	pig	NNS
cord-015021-pol2qm74	7620	23	.	.	.
cord-015021-pol2qm74	7621	1	Treatment	treatment	NN
cord-015021-pol2qm74	7621	2	with	with	IN
cord-015021-pol2qm74	7621	3	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7621	4	also	also	RB
cord-015021-pol2qm74	7621	5	increases	increase	VBZ
cord-015021-pol2qm74	7621	6	survival	survival	NN
cord-015021-pol2qm74	7621	7	and	and	CC
cord-015021-pol2qm74	7621	8	decreases	decrease	VBZ
cord-015021-pol2qm74	7621	9	cytokine	cytokine	NN
cord-015021-pol2qm74	7621	10	production	production	NN
cord-015021-pol2qm74	7621	11	in	in	IN
cord-015021-pol2qm74	7621	12	bacterial	bacterial	JJ
cord-015021-pol2qm74	7621	13	challenge	challenge	NN
cord-015021-pol2qm74	7621	14	models	model	NNS
cord-015021-pol2qm74	7621	15	in	in	IN
cord-015021-pol2qm74	7621	16	rats	rat	NNS
cord-015021-pol2qm74	7621	17	and	and	CC
cord-015021-pol2qm74	7621	18	mice	mouse	NNS
cord-015021-pol2qm74	7621	19	.	.	.
cord-015021-pol2qm74	7622	1	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7622	2	was	be	VBD
cord-015021-pol2qm74	7622	3	not	not	RB
cord-015021-pol2qm74	7622	4	toxic	toxic	JJ
cord-015021-pol2qm74	7622	5	to	to	IN
cord-015021-pol2qm74	7622	6	rats	rat	NNS
cord-015021-pol2qm74	7622	7	after	after	IN
cord-015021-pol2qm74	7622	8	10	10	CD
cord-015021-pol2qm74	7622	9	daily	daily	JJ
cord-015021-pol2qm74	7622	10	consecutive	consecutive	JJ
cord-015021-pol2qm74	7622	11	i.v	i.v	NNP
cord-015021-pol2qm74	7622	12	.	.	.
cord-015021-pol2qm74	7622	13	doses	dose	NNS
cord-015021-pol2qm74	7622	14	of	of	IN
cord-015021-pol2qm74	7622	15	10	10	CD
cord-015021-pol2qm74	7622	16	mg	mg	NNP
cord-015021-pol2qm74	7622	17	/	/	SYM
cord-015021-pol2qm74	7622	18	kg	kg	NN
cord-015021-pol2qm74	7622	19	.	.	.
cord-015021-pol2qm74	7623	1	This	this	DT
cord-015021-pol2qm74	7623	2	combination	combination	NN
cord-015021-pol2qm74	7623	3	of	of	IN
cord-015021-pol2qm74	7623	4	properties	property	NNS
cord-015021-pol2qm74	7623	5	indicate	indicate	VBP
cord-015021-pol2qm74	7623	6	that	that	IN
cord-015021-pol2qm74	7623	7	recombinant	recombinant	JJ
cord-015021-pol2qm74	7623	8	BPI	BPI	NNP
cord-015021-pol2qm74	7623	9	may	may	MD
cord-015021-pol2qm74	7623	10	be	be	VB
cord-015021-pol2qm74	7623	11	useful	useful	JJ
cord-015021-pol2qm74	7623	12	in	in	IN
cord-015021-pol2qm74	7623	13	the	the	DT
cord-015021-pol2qm74	7623	14	treatment	treatment	NN
cord-015021-pol2qm74	7623	15	of	of	IN
cord-015021-pol2qm74	7623	16	sepsis	sepsis	NN
cord-015021-pol2qm74	7623	17	.	.	.
cord-015021-pol2qm74	7624	1	Phase	phase	NN
cord-015021-pol2qm74	7624	2	I	I	NNP
cord-015021-pol2qm74	7624	3	/	/	SYM
cord-015021-pol2qm74	7624	4	II	II	NNP
cord-015021-pol2qm74	7624	5	clinical	clinical	JJ
cord-015021-pol2qm74	7624	6	trials	trial	NNS
cord-015021-pol2qm74	7624	7	of	of	IN
cord-015021-pol2qm74	7624	8	rBPI23	rBPI23	NNP
cord-015021-pol2qm74	7624	9	have	have	VBP
cord-015021-pol2qm74	7624	10	begun	begin	VBN
cord-015021-pol2qm74	7624	11	.	.	.
cord-015021-pol2qm74	7625	1	The	the	DT
cord-015021-pol2qm74	7625	2	discovery	discovery	NN
cord-015021-pol2qm74	7625	3	of	of	IN
cord-015021-pol2qm74	7625	4	LPS	LPS	NNP
cord-015021-pol2qm74	7625	5	binding	bind	VBG
cord-015021-pol2qm74	7625	6	protein	protein	NN
cord-015021-pol2qm74	7625	7	(	(	-LRB-
cord-015021-pol2qm74	7625	8	LBP	LBP	NNP
cord-015021-pol2qm74	7625	9	)	)	-RRB-
cord-015021-pol2qm74	7625	10	and	and	CC
cord-015021-pol2qm74	7625	11	subsequent	subsequent	JJ
cord-015021-pol2qm74	7625	12	identification	identification	NN
cord-015021-pol2qm74	7625	13	of	of	IN
cord-015021-pol2qm74	7625	14	CD14	CD14	NNP
cord-015021-pol2qm74	7625	15	as	as	IN
cord-015021-pol2qm74	7625	16	a	a	DT
cord-015021-pol2qm74	7625	17	receptor	receptor	NN
cord-015021-pol2qm74	7625	18	for	for	IN
cord-015021-pol2qm74	7625	19	LPS	LPS	NNP
cord-015021-pol2qm74	7625	20	or	or	CC
cord-015021-pol2qm74	7625	21	LPS	LPS	NNP
cord-015021-pol2qm74	7625	22	-	-	HYPH
cord-015021-pol2qm74	7625	23	LBP	LBP	NNP
cord-015021-pol2qm74	7625	24	complexes	complex	NNS
cord-015021-pol2qm74	7625	25	has	have	VBZ
cord-015021-pol2qm74	7625	26	resulted	result	VBN
cord-015021-pol2qm74	7625	27	in	in	IN
cord-015021-pol2qm74	7625	28	a	a	DT
cord-015021-pol2qm74	7625	29	new	new	JJ
cord-015021-pol2qm74	7625	30	understanding	understanding	NN
cord-015021-pol2qm74	7625	31	o£	o£	IN
cord-015021-pol2qm74	7625	32	how	how	WRB
cord-015021-pol2qm74	7625	33	LPS	LPS	NNP
cord-015021-pol2qm74	7625	34	responsive	responsive	JJ
cord-015021-pol2qm74	7625	35	ceils	ceil	NNS
cord-015021-pol2qm74	7625	36	are	be	VBP
cord-015021-pol2qm74	7625	37	stimulated	stimulate	VBN
cord-015021-pol2qm74	7625	38	.	.	.
cord-015021-pol2qm74	7626	1	CD14	CD14	NNP
cord-015021-pol2qm74	7626	2	is	be	VBZ
cord-015021-pol2qm74	7626	3	found	find	VBN
cord-015021-pol2qm74	7626	4	either	either	CC
cord-015021-pol2qm74	7626	5	as	as	IN
cord-015021-pol2qm74	7626	6	a	a	DT
cord-015021-pol2qm74	7626	7	glycosylphosphatidyl	glycosylphosphatidyl	NN
cord-015021-pol2qm74	7626	8	-	-	HYPH
cord-015021-pol2qm74	7626	9	inositol	inositol	JJ
cord-015021-pol2qm74	7626	10	(	(	-LRB-
cord-015021-pol2qm74	7626	11	GPI)-anehored	gpi)-anehore	VBN
cord-015021-pol2qm74	7626	12	membrane	membrane	NN
cord-015021-pol2qm74	7626	13	glycoprotein	glycoprotein	NN
cord-015021-pol2qm74	7626	14	(	(	-LRB-
cord-015021-pol2qm74	7626	15	mCD14	mCD14	NNP
cord-015021-pol2qm74	7626	16	)	)	-RRB-
cord-015021-pol2qm74	7626	17	of	of	IN
cord-015021-pol2qm74	7626	18	myeloid	myeloid	NN
cord-015021-pol2qm74	7626	19	cells	cell	NNS
cord-015021-pol2qm74	7626	20	or	or	CC
cord-015021-pol2qm74	7626	21	as	as	IN
cord-015021-pol2qm74	7626	22	a	a	DT
cord-015021-pol2qm74	7626	23	soluble	soluble	JJ
cord-015021-pol2qm74	7626	24	serum	serum	NN
cord-015021-pol2qm74	7626	25	protein	protein	NN
cord-015021-pol2qm74	7626	26	(	(	-LRB-
cord-015021-pol2qm74	7626	27	sCD14	sCD14	NNP
cord-015021-pol2qm74	7626	28	)	)	-RRB-
cord-015021-pol2qm74	7626	29	lacking	lack	VBG
cord-015021-pol2qm74	7626	30	the	the	DT
cord-015021-pol2qm74	7626	31	GPI	GPI	NNP
cord-015021-pol2qm74	7626	32	-	-	HYPH
cord-015021-pol2qm74	7626	33	anchor	anchor	NN
cord-015021-pol2qm74	7626	34	.	.	.
cord-015021-pol2qm74	7627	1	Binding	bind	VBG
cord-015021-pol2qm74	7627	2	of	of	IN
cord-015021-pol2qm74	7627	3	LPS	LPS	NNP
cord-015021-pol2qm74	7627	4	to	to	TO
cord-015021-pol2qm74	7627	5	mCD	mcd	VB
cord-015021-pol2qm74	7627	6	14	14	CD
cord-015021-pol2qm74	7627	7	triggers	trigger	VBZ
cord-015021-pol2qm74	7627	8	cell	cell	NN
cord-015021-pol2qm74	7627	9	activation	activation	NN
cord-015021-pol2qm74	7627	10	while	while	IN
cord-015021-pol2qm74	7627	11	binding	bind	VBG
cord-015021-pol2qm74	7627	12	of	of	IN
cord-015021-pol2qm74	7627	13	LPS	LPS	NNP
cord-015021-pol2qm74	7627	14	-	-	HYPH
cord-015021-pol2qm74	7627	15	sCD14	scd14	NN
cord-015021-pol2qm74	7627	16	complexes	complex	NNS
cord-015021-pol2qm74	7627	17	to	to	TO
cord-015021-pol2qm74	7627	18	cells	cell	NNS
cord-015021-pol2qm74	7627	19	such	such	JJ
cord-015021-pol2qm74	7627	20	as	as	IN
cord-015021-pol2qm74	7627	21	endothelial	endothelial	JJ
cord-015021-pol2qm74	7627	22	or	or	CC
cord-015021-pol2qm74	7627	23	epithelial	epithelial	JJ
cord-015021-pol2qm74	7627	24	cells	cell	NNS
cord-015021-pol2qm74	7627	25	that	that	WDT
cord-015021-pol2qm74	7627	26	normally	normally	RB
cord-015021-pol2qm74	7627	27	do	do	VBP
cord-015021-pol2qm74	7627	28	not	not	RB
cord-015021-pol2qm74	7627	29	express	express	VB
cord-015021-pol2qm74	7627	30	mCD14	mCD14	NNP
cord-015021-pol2qm74	7627	31	activates	activate	VBZ
cord-015021-pol2qm74	7627	32	these	these	DT
cord-015021-pol2qm74	7627	33	cells	cell	NNS
cord-015021-pol2qm74	7627	34	.	.	.
cord-015021-pol2qm74	7628	1	These	these	DT
cord-015021-pol2qm74	7628	2	pathways	pathway	NNS
cord-015021-pol2qm74	7628	3	are	be	VBP
cord-015021-pol2qm74	7628	4	shown	show	VBN
cord-015021-pol2qm74	7628	5	in	in	IN
cord-015021-pol2qm74	7628	6	schematic	schematic	JJ
cord-015021-pol2qm74	7628	7	form	form	NN
cord-015021-pol2qm74	7628	8	below	below	RB
cord-015021-pol2qm74	7628	9	.	.	.
cord-015021-pol2qm74	7629	1	4	4	LS
cord-015021-pol2qm74	7630	1	~DI	~DI	NFP
cord-015021-pol2qm74	7631	1	mCD14	mCD14	NNP
cord-015021-pol2qm74	7631	2	plays	play	VBZ
cord-015021-pol2qm74	7631	3	a	a	DT
cord-015021-pol2qm74	7631	4	crucial	crucial	JJ
cord-015021-pol2qm74	7631	5	role	role	NN
cord-015021-pol2qm74	7631	6	in	in	IN
cord-015021-pol2qm74	7631	7	presentation	presentation	NN
cord-015021-pol2qm74	7631	8	of	of	IN
cord-015021-pol2qm74	7631	9	LPS	lp	NNS
cord-015021-pol2qm74	7631	10	to	to	IN
cord-015021-pol2qm74	7631	11	additional	additional	JJ
cord-015021-pol2qm74	7631	12	membrane	membrane	NN
cord-015021-pol2qm74	7631	13	components	component	NNS
cord-015021-pol2qm74	7631	14	that	that	WDT
cord-015021-pol2qm74	7631	15	make	make	VBP
cord-015021-pol2qm74	7631	16	up	up	RP
cord-015021-pol2qm74	7631	17	a	a	DT
cord-015021-pol2qm74	7631	18	functional	functional	JJ
cord-015021-pol2qm74	7631	19	LPS	LPS	NNP
cord-015021-pol2qm74	7631	20	receptor	receptor	NN
cord-015021-pol2qm74	7631	21	.	.	.
cord-015021-pol2qm74	7632	1	An	an	DT
cord-015021-pol2qm74	7632	2	immediate	immediate	JJ
cord-015021-pol2qm74	7632	3	consequence	consequence	NN
cord-015021-pol2qm74	7632	4	of	of	IN
cord-015021-pol2qm74	7632	5	engagement	engagement	NN
cord-015021-pol2qm74	7632	6	of	of	IN
cord-015021-pol2qm74	7632	7	this	this	DT
cord-015021-pol2qm74	7632	8	functional	functional	JJ
cord-015021-pol2qm74	7632	9	receptor	receptor	NN
cord-015021-pol2qm74	7632	10	is	be	VBZ
cord-015021-pol2qm74	7632	11	protein	protein	NN
cord-015021-pol2qm74	7632	12	tyrosine	tyrosine	NN
cord-015021-pol2qm74	7632	13	phosphorylation	phosphorylation	NN
cord-015021-pol2qm74	7632	14	.	.	.
cord-015021-pol2qm74	7633	1	The	the	DT
cord-015021-pol2qm74	7633	2	molecular	molecular	JJ
cord-015021-pol2qm74	7633	3	mechanisms	mechanism	NNS
cord-015021-pol2qm74	7633	4	leading	lead	VBG
cord-015021-pol2qm74	7633	5	to	to	IN
cord-015021-pol2qm74	7633	6	these	these	DT
cord-015021-pol2qm74	7633	7	events	event	NNS
cord-015021-pol2qm74	7633	8	will	will	MD
cord-015021-pol2qm74	7633	9	be	be	VB
cord-015021-pol2qm74	7633	10	discussed	discuss	VBN
cord-015021-pol2qm74	7633	11	.	.	.
cord-015021-pol2qm74	7634	1	Understanding	understanding	NN
cord-015021-pol2qm74	7634	2	of	of	IN
cord-015021-pol2qm74	7634	3	these	these	DT
cord-015021-pol2qm74	7634	4	pathways	pathway	NNS
cord-015021-pol2qm74	7634	5	will	will	MD
cord-015021-pol2qm74	7634	6	lead	lead	VB
cord-015021-pol2qm74	7634	7	to	to	IN
cord-015021-pol2qm74	7634	8	the	the	DT
cord-015021-pol2qm74	7634	9	development	development	NN
cord-015021-pol2qm74	7634	10	of	of	IN
cord-015021-pol2qm74	7634	11	new	new	JJ
cord-015021-pol2qm74	7634	12	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7634	13	approaches	approach	NNS
cord-015021-pol2qm74	7634	14	to	to	IN
cord-015021-pol2qm74	7634	15	controlling	control	VBG
cord-015021-pol2qm74	7634	16	host	host	NN
cord-015021-pol2qm74	7634	17	responses	response	NNS
cord-015021-pol2qm74	7634	18	to	to	IN
cord-015021-pol2qm74	7634	19	LPS	lp	NNS
cord-015021-pol2qm74	7634	20	.	.	.
cord-015021-pol2qm74	7635	1	Pretreatmen	Pretreatmen	NNP
cord-015021-pol2qm74	7635	2	t	t	NNP
cord-015021-pol2qm74	7635	3	Posttreatment	Posttreatment	NNP
cord-015021-pol2qm74	7635	4	(	(	-LRB-
cord-015021-pol2qm74	7635	5	before	before	IN
cord-015021-pol2qm74	7635	6	or	or	CC
cord-015021-pol2qm74	7635	7	after	after	IN
cord-015021-pol2qm74	7635	8	TNF	TNF	NNP
cord-015021-pol2qm74	7635	9	peak	peak	NN
cord-015021-pol2qm74	7635	10	)	)	-RRB-
cord-015021-pol2qm74	7635	11	D	D	NNP
cord-015021-pol2qm74	7635	12	)	)	-RRB-
cord-015021-pol2qm74	7635	13	with	with	IN
cord-015021-pol2qm74	7635	14	different	different	JJ
cord-015021-pol2qm74	7635	15	antibody	antibody	NN
cord-015021-pol2qm74	7635	16	dosages	dosage	NNS
cord-015021-pol2qm74	7635	17	:	:	:
cord-015021-pol2qm74	7636	1	15	15	CD
cord-015021-pol2qm74	7636	2	mg	mg	NNP
cord-015021-pol2qm74	7636	3	/	/	SYM
cord-015021-pol2qm74	7636	4	kg	kg	NNP
cord-015021-pol2qm74	7637	1	---0.1	---0.1	NFP
cord-015021-pol2qm74	7637	2	mg	mg	NNP
cord-015021-pol2qm74	7637	3	/	/	SYM
cord-015021-pol2qm74	7637	4	kg	kg	NNP
cord-015021-pol2qm74	7638	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	7638	2	with	with	IN
cord-015021-pol2qm74	7638	3	anti	anti	AFX
cord-015021-pol2qm74	7638	4	-	-	JJ
cord-015021-pol2qm74	7638	5	TNFab	tnfab	RB
cord-015021-pol2qm74	7638	6	prevented	prevent	VBN
cord-015021-pol2qm74	7638	7	death	death	NN
cord-015021-pol2qm74	7638	8	in	in	IN
cord-015021-pol2qm74	7638	9	most	most	JJS
cord-015021-pol2qm74	7638	10	model	model	NN
cord-015021-pol2qm74	7638	11	situations	situation	NNS
cord-015021-pol2qm74	7638	12	(	(	-LRB-
cord-015021-pol2qm74	7638	13	except	except	IN
cord-015021-pol2qm74	7638	14	peritonitis	peritonitis	NN
cord-015021-pol2qm74	7638	15	)	)	-RRB-
cord-015021-pol2qm74	7638	16	,	,	,
cord-015021-pol2qm74	7638	17	but	but	CC
cord-015021-pol2qm74	7638	18	also	also	RB
cord-015021-pol2qm74	7638	19	posttreatment	posttreatment	VB
cord-015021-pol2qm74	7638	20	up	up	RP
cord-015021-pol2qm74	7638	21	to	to	IN
cord-015021-pol2qm74	7638	22	4h	4h	CD
cord-015021-pol2qm74	7638	23	after	after	IN
cord-015021-pol2qm74	7638	24	sepsis	sepsis	NN
cord-015021-pol2qm74	7638	25	induction	induction	NN
cord-015021-pol2qm74	7638	26	was	be	VBD
cord-015021-pol2qm74	7638	27	successful	successful	JJ
cord-015021-pol2qm74	7638	28	in	in	IN
cord-015021-pol2qm74	7638	29	the	the	DT
cord-015021-pol2qm74	7638	30	few	few	JJ
cord-015021-pol2qm74	7638	31	studies	study	NNS
cord-015021-pol2qm74	7638	32	performed	perform	VBN
cord-015021-pol2qm74	7638	33	.	.	.
cord-015021-pol2qm74	7639	1	There	there	EX
cord-015021-pol2qm74	7639	2	is	be	VBZ
cord-015021-pol2qm74	7639	3	additional	additional	JJ
cord-015021-pol2qm74	7639	4	evidence	evidence	NN
cord-015021-pol2qm74	7639	5	that	that	IN
cord-015021-pol2qm74	7639	6	low	low	JJ
cord-015021-pol2qm74	7639	7	-	-	HYPH
cord-015021-pol2qm74	7639	8	dose	dose	NN
cord-015021-pol2qm74	7639	9	TNFab	TNFab	NNP
cord-015021-pol2qm74	7639	10	is	be	VBZ
cord-015021-pol2qm74	7639	11	partially	partially	RB
cord-015021-pol2qm74	7639	12	effective	effective	JJ
cord-015021-pol2qm74	7639	13	.	.	.
cord-015021-pol2qm74	7640	1	Especially	especially	RB
cord-015021-pol2qm74	7640	2	baboon	baboon	NN
cord-015021-pol2qm74	7640	3	anti	anti	NN
cord-015021-pol2qm74	7640	4	-	-	NNP
cord-015021-pol2qm74	7640	5	TNFab	TNFab	NNP
cord-015021-pol2qm74	7640	6	studies	study	NNS
cord-015021-pol2qm74	7640	7	provided	provide	VBD
cord-015021-pol2qm74	7640	8	many	many	JJ
cord-015021-pol2qm74	7640	9	insights	insight	NNS
cord-015021-pol2qm74	7640	10	into	into	IN
cord-015021-pol2qm74	7640	11	the	the	DT
cord-015021-pol2qm74	7640	12	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	7640	13	sequences	sequence	NNS
cord-015021-pol2qm74	7640	14	of	of	IN
cord-015021-pol2qm74	7640	15	sepsis	sepsis	NN
cord-015021-pol2qm74	7640	16	induction	induction	NN
cord-015021-pol2qm74	7640	17	,	,	,
cord-015021-pol2qm74	7640	18	due	due	IN
cord-015021-pol2qm74	7640	19	to	to	IN
cord-015021-pol2qm74	7640	20	crossreactivity	crossreactivity	NN
cord-015021-pol2qm74	7640	21	with	with	IN
cord-015021-pol2qm74	7640	22	human	human	JJ
cord-015021-pol2qm74	7640	23	reagents	reagent	NNS
cord-015021-pol2qm74	7640	24	.	.	.
cord-015021-pol2qm74	7641	1	Those	those	DT
cord-015021-pol2qm74	7641	2	events	event	NNS
cord-015021-pol2qm74	7641	3	include	include	VBP
cord-015021-pol2qm74	7641	4	the	the	DT
cord-015021-pol2qm74	7641	5	cytokine	cytokine	NN
cord-015021-pol2qm74	7641	6	sequence	sequence	NN
cord-015021-pol2qm74	7641	7	with	with	IN
cord-015021-pol2qm74	7641	8	TNF	TNF	NNP
cord-015021-pol2qm74	7641	9	-	-	HYPH
cord-015021-pol2qm74	7641	10	dependent	dependent	JJ
cord-015021-pol2qm74	7641	11	IL	IL	NNP
cord-015021-pol2qm74	7641	12	-	-	:
cord-015021-pol2qm74	7641	13	I	I	NNP
cord-015021-pol2qm74	7641	14	,	,	,
cord-015021-pol2qm74	7641	15	IL-6	IL-6	NNP
cord-015021-pol2qm74	7641	16	,	,	,
cord-015021-pol2qm74	7641	17	or	or	CC
cord-015021-pol2qm74	7641	18	IL-8	IL-8	NNP
cord-015021-pol2qm74	7641	19	,	,	,
cord-015021-pol2qm74	7641	20	but	but	CC
cord-015021-pol2qm74	7641	21	also	also	RB
cord-015021-pol2qm74	7641	22	IL	IL	NNP
cord-015021-pol2qm74	7641	23	-	-	HYPH
cord-015021-pol2qm74	7641	24	lra	lra	NNP
cord-015021-pol2qm74	7641	25	or	or	CC
cord-015021-pol2qm74	7641	26	sTNF	sTNF	NNP
cord-015021-pol2qm74	7641	27	receptor	receptor	NN
cord-015021-pol2qm74	7641	28	release	release	NN
cord-015021-pol2qm74	7641	29	.	.	.
cord-015021-pol2qm74	7642	1	Granulocyte	Granulocyte	NNP
cord-015021-pol2qm74	7642	2	as	as	RB
cord-015021-pol2qm74	7642	3	well	well	RB
cord-015021-pol2qm74	7642	4	as	as	IN
cord-015021-pol2qm74	7642	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	7642	6	cell	cell	NN
cord-015021-pol2qm74	7642	7	activation	activation	NN
cord-015021-pol2qm74	7642	8	were	be	VBD
cord-015021-pol2qm74	7642	9	shown	show	VBN
cord-015021-pol2qm74	7642	10	to	to	TO
cord-015021-pol2qm74	7642	11	be	be	VB
cord-015021-pol2qm74	7642	12	partly	partly	RB
cord-015021-pol2qm74	7642	13	TNF	TNF	NNP
cord-015021-pol2qm74	7642	14	related	relate	VBN
cord-015021-pol2qm74	7642	15	,	,	,
cord-015021-pol2qm74	7642	16	and	and	CC
cord-015021-pol2qm74	7642	17	the	the	DT
cord-015021-pol2qm74	7642	18	procoagulatory	procoagulatory	NNP
cord-015021-pol2qm74	7642	19	response	response	NN
cord-015021-pol2qm74	7642	20	was	be	VBD
cord-015021-pol2qm74	7642	21	influenced	influence	VBN
cord-015021-pol2qm74	7642	22	by	by	IN
cord-015021-pol2qm74	7642	23	anti	anti	JJ
cord-015021-pol2qm74	7642	24	-	-	JJ
cord-015021-pol2qm74	7642	25	TNF	TNF	NNP
cord-015021-pol2qm74	7642	26	treatment	treatment	NN
cord-015021-pol2qm74	7642	27	.	.	.
cord-015021-pol2qm74	7643	1	From	from	IN
cord-015021-pol2qm74	7643	2	many	many	JJ
cord-015021-pol2qm74	7643	3	animal	animal	NN
cord-015021-pol2qm74	7643	4	studies	study	NNS
cord-015021-pol2qm74	7643	5	the	the	DT
cord-015021-pol2qm74	7643	6	concept	concept	NN
cord-015021-pol2qm74	7643	7	that	that	WDT
cord-015021-pol2qm74	7643	8	TNF	TNF	NNP
cord-015021-pol2qm74	7643	9	plays	play	VBZ
cord-015021-pol2qm74	7643	10	a	a	DT
cord-015021-pol2qm74	7643	11	pivotal	pivotal	JJ
cord-015021-pol2qm74	7643	12	role	role	NN
cord-015021-pol2qm74	7643	13	in	in	IN
cord-015021-pol2qm74	7643	14	sepsis	sepsis	NN
cord-015021-pol2qm74	7643	15	is	be	VBZ
cord-015021-pol2qm74	7643	16	clearly	clearly	RB
cord-015021-pol2qm74	7643	17	evident	evident	JJ
cord-015021-pol2qm74	7643	18	and	and	CC
cord-015021-pol2qm74	7643	19	therefore	therefore	RB
cord-015021-pol2qm74	7643	20	anti	anti	JJ
cord-015021-pol2qm74	7643	21	-	-	JJ
cord-015021-pol2qm74	7643	22	TNF	TNF	NNP
cord-015021-pol2qm74	7643	23	therapy	therapy	NN
cord-015021-pol2qm74	7643	24	is	be	VBZ
cord-015021-pol2qm74	7643	25	a	a	DT
cord-015021-pol2qm74	7643	26	major	major	JJ
cord-015021-pol2qm74	7643	27	candidate	candidate	NN
cord-015021-pol2qm74	7643	28	tbr	tbr	NNP
cord-015021-pol2qm74	7643	29	clinical	clinical	JJ
cord-015021-pol2qm74	7643	30	studies	study	NNS
cord-015021-pol2qm74	7643	31	.	.	.
cord-015021-pol2qm74	7644	1	The	the	DT
cord-015021-pol2qm74	7644	2	beneficial	beneficial	JJ
cord-015021-pol2qm74	7644	3	or	or	CC
cord-015021-pol2qm74	7644	4	harmful	harmful	JJ
cord-015021-pol2qm74	7644	5	effects	effect	NNS
cord-015021-pol2qm74	7644	6	of	of	IN
cord-015021-pol2qm74	7644	7	TNF	tnf	NN
cord-015021-pol2qm74	7644	8	-	-	HYPH
cord-015021-pol2qm74	7644	9	mediated	mediate	VBN
cord-015021-pol2qm74	7644	10	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7644	11	responses	response	NNS
cord-015021-pol2qm74	7644	12	depend	depend	VBP
cord-015021-pol2qm74	7644	13	on	on	IN
cord-015021-pol2qm74	7644	14	the	the	DT
cord-015021-pol2qm74	7644	15	clinical	clinical	JJ
cord-015021-pol2qm74	7644	16	context	context	NN
cord-015021-pol2qm74	7644	17	.	.	.
cord-015021-pol2qm74	7645	1	Decreasing	decrease	VBG
cord-015021-pol2qm74	7645	2	exaggerated	exaggerated	JJ
cord-015021-pol2qm74	7645	3	TNF	tnf	NN
cord-015021-pol2qm74	7645	4	-	-	HYPH
cord-015021-pol2qm74	7645	5	mediated	mediate	VBN
cord-015021-pol2qm74	7645	6	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7645	7	responses	response	NNS
cord-015021-pol2qm74	7645	8	may	may	MD
cord-015021-pol2qm74	7645	9	be	be	VB
cord-015021-pol2qm74	7645	10	useful	useful	JJ
cord-015021-pol2qm74	7645	11	in	in	IN
cord-015021-pol2qm74	7645	12	some	some	DT
cord-015021-pol2qm74	7645	13	patients	patient	NNS
cord-015021-pol2qm74	7645	14	with	with	IN
cord-015021-pol2qm74	7645	15	organ	organ	NN
cord-015021-pol2qm74	7645	16	failure	failure	NN
cord-015021-pol2qm74	7645	17	.	.	.
cord-015021-pol2qm74	7646	1	TNFR	TNFR	NNP
cord-015021-pol2qm74	7646	2	:	:	:
cord-015021-pol2qm74	7647	1	Fc	Fc	NNP
cord-015021-pol2qm74	7647	2	(	(	-LRB-
cord-015021-pol2qm74	7647	3	Immunex	Immunex	NNP
cord-015021-pol2qm74	7647	4	,	,	,
cord-015021-pol2qm74	7647	5	Seattle	Seattle	NNP
cord-015021-pol2qm74	7647	6	,	,	,
cord-015021-pol2qm74	7647	7	WA	WA	NNP
cord-015021-pol2qm74	7647	8	)	)	-RRB-
cord-015021-pol2qm74	7647	9	is	be	VBZ
cord-015021-pol2qm74	7647	10	a	a	DT
cord-015021-pol2qm74	7647	11	recombinant	recombinant	JJ
cord-015021-pol2qm74	7647	12	human	human	JJ
cord-015021-pol2qm74	7647	13	protein	protein	NN
cord-015021-pol2qm74	7647	14	composed	compose	VBN
cord-015021-pol2qm74	7647	15	of	of	IN
cord-015021-pol2qm74	7647	16	two	two	CD
cord-015021-pol2qm74	7647	17	identical	identical	JJ
cord-015021-pol2qm74	7647	18	extracellular	extracellular	JJ
cord-015021-pol2qm74	7647	19	p80	p80	NN
cord-015021-pol2qm74	7647	20	TNF	TNF	NNP
cord-015021-pol2qm74	7647	21	receptors	receptor	NNS
cord-015021-pol2qm74	7647	22	linked	link	VBN
cord-015021-pol2qm74	7647	23	by	by	IN
cord-015021-pol2qm74	7647	24	the	the	DT
cord-015021-pol2qm74	7647	25	Fc	Fc	NNP
cord-015021-pol2qm74	7647	26	region	region	NN
cord-015021-pol2qm74	7647	27	of	of	IN
cord-015021-pol2qm74	7647	28	IgGl	IgGl	NNP
cord-015021-pol2qm74	7647	29	.	.	.
cord-015021-pol2qm74	7648	1	It	-PRON-	PRP
cord-015021-pol2qm74	7648	2	neutralizes	neutralize	VBZ
cord-015021-pol2qm74	7648	3	TNF	TNF	NNP
cord-015021-pol2qm74	7648	4	with	with	IN
cord-015021-pol2qm74	7648	5	an	an	DT
cord-015021-pol2qm74	7648	6	affinity	affinity	NN
cord-015021-pol2qm74	7648	7	for	for	IN
cord-015021-pol2qm74	7648	8	TNF	TNF	NNP
cord-015021-pol2qm74	7648	9	<	<	XX
cord-015021-pol2qm74	7648	10	z	z	NNP
cord-015021-pol2qm74	7648	11	of	of	IN
cord-015021-pol2qm74	7648	12	10	10	CD
cord-015021-pol2qm74	7648	13	-	-	SYM
cord-015021-pol2qm74	7648	14	10	10	CD
cord-015021-pol2qm74	7648	15	M	M	NNP
cord-015021-pol2qm74	7648	16	and	and	CC
cord-015021-pol2qm74	7648	17	has	have	VBZ
cord-015021-pol2qm74	7648	18	a	a	DT
cord-015021-pol2qm74	7648	19	T1/2	t1/2	NN
cord-015021-pol2qm74	7648	20	of	of	IN
cord-015021-pol2qm74	7648	21	•	•	NNP
cord-015021-pol2qm74	7648	22	63h	63h	CD
cord-015021-pol2qm74	7648	23	in	in	IN
cord-015021-pol2qm74	7648	24	normal	normal	JJ
cord-015021-pol2qm74	7648	25	humans	human	NNS
cord-015021-pol2qm74	7648	26	.	.	.
cord-015021-pol2qm74	7649	1	Methods	method	NNS
cord-015021-pol2qm74	7649	2	:	:	:
cord-015021-pol2qm74	7649	3	18	18	CD
cord-015021-pol2qm74	7649	4	normal	normal	JJ
cord-015021-pol2qm74	7649	5	volunteers	volunteer	NNS
cord-015021-pol2qm74	7649	6	were	be	VBD
cord-015021-pol2qm74	7649	7	randomized	randomize	VBN
cord-015021-pol2qm74	7649	8	to	to	TO
cord-015021-pol2qm74	7649	9	receive	receive	VB
cord-015021-pol2qm74	7649	10	either	either	DT
cord-015021-pol2qm74	7649	11	TNFR	TNFR	NNP
cord-015021-pol2qm74	7649	12	:	:	:
cord-015021-pol2qm74	7650	1	Fc	Fc	NNP
cord-015021-pol2qm74	7650	2	vehicle	vehicle	NN
cord-015021-pol2qm74	7650	3	(	(	-LRB-
cord-015021-pol2qm74	7650	4	n=6	n=6	NNP
cord-015021-pol2qm74	7650	5	)	)	-RRB-
cord-015021-pol2qm74	7650	6	,	,	,
cord-015021-pol2qm74	7650	7	or	or	CC
cord-015021-pol2qm74	7650	8	low	low	JJ
cord-015021-pol2qm74	7650	9	dose	dose	NN
cord-015021-pol2qm74	7650	10	(	(	-LRB-
cord-015021-pol2qm74	7650	11	LD	LD	NNP
cord-015021-pol2qm74	7650	12	)	)	-RRB-
cord-015021-pol2qm74	7650	13	TNFR	TNFR	NNP
cord-015021-pol2qm74	7650	14	:	:	:
cord-015021-pol2qm74	7650	15	Fc	Fc	NNP
cord-015021-pol2qm74	7650	16	(	(	-LRB-
cord-015021-pol2qm74	7650	17	10	10	CD
cord-015021-pol2qm74	7650	18	mg	mg	NNP
cord-015021-pol2qm74	7650	19	/	/	SYM
cord-015021-pol2qm74	7650	20	m	m	NNP
cord-015021-pol2qm74	7650	21	2	2	CD
cord-015021-pol2qm74	7650	22	iv	iv	CD
cord-015021-pol2qm74	7650	23	,	,	,
cord-015021-pol2qm74	7650	24	n=6	n=6	NNP
cord-015021-pol2qm74	7650	25	)	)	-RRB-
cord-015021-pol2qm74	7650	26	,	,	,
cord-015021-pol2qm74	7650	27	or	or	CC
cord-015021-pol2qm74	7650	28	high	high	JJ
cord-015021-pol2qm74	7650	29	dose	dose	NN
cord-015021-pol2qm74	7650	30	(	(	-LRB-
cord-015021-pol2qm74	7650	31	HD	HD	NNP
cord-015021-pol2qm74	7650	32	)	)	-RRB-
cord-015021-pol2qm74	7650	33	TNFR	TNFR	NNP
cord-015021-pol2qm74	7650	34	:	:	:
cord-015021-pol2qm74	7651	1	Fc	Fc	NNP
cord-015021-pol2qm74	7651	2	(	(	-LRB-
cord-015021-pol2qm74	7651	3	60	60	CD
cord-015021-pol2qm74	7651	4	mg	mg	NNP
cord-015021-pol2qm74	7651	5	/	/	SYM
cord-015021-pol2qm74	7651	6	m	m	NN
cord-015021-pol2qm74	7651	7	2	2	CD
cord-015021-pol2qm74	7652	1	iv	iv	LS
cord-015021-pol2qm74	7652	2	,	,	,
cord-015021-pol2qm74	7652	3	n=6	n=6	NNP
cord-015021-pol2qm74	7652	4	)	)	-RRB-
cord-015021-pol2qm74	7652	5	infused	infuse	VBN
cord-015021-pol2qm74	7652	6	over	over	IN
cord-015021-pol2qm74	7652	7	30	30	CD
cord-015021-pol2qm74	7652	8	rain	rain	NN
cord-015021-pol2qm74	7652	9	prior	prior	RB
cord-015021-pol2qm74	7652	10	to	to	IN
cord-015021-pol2qm74	7652	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7652	12	(	(	-LRB-
cord-015021-pol2qm74	7652	13	E	e	NN
cord-015021-pol2qm74	7652	14	)	)	-RRB-
cord-015021-pol2qm74	7653	1	(	(	-LRB-
cord-015021-pol2qm74	7653	2	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	7653	3	coil	coil	NN
cord-015021-pol2qm74	7653	4	0:113	0:113	CD
cord-015021-pol2qm74	7653	5	;	;	:
cord-015021-pol2qm74	7653	6	4	4	CD
cord-015021-pol2qm74	7653	7	ng	ng	NNP
cord-015021-pol2qm74	7653	8	/	/	SYM
cord-015021-pol2qm74	7653	9	kg	kg	NNP
cord-015021-pol2qm74	7653	10	iv	iv	NNP
cord-015021-pol2qm74	7653	11	)	)	-RRB-
cord-015021-pol2qm74	7653	12	administration	administration	NN
cord-015021-pol2qm74	7653	13	.	.	.
cord-015021-pol2qm74	7654	1	Plasma	plasma	NN
cord-015021-pol2qm74	7654	2	cytokines	cytokine	NNS
cord-015021-pol2qm74	7654	3	were	be	VBD
cord-015021-pol2qm74	7654	4	measured	measure	VBN
cord-015021-pol2qm74	7654	5	using	use	VBG
cord-015021-pol2qm74	7654	6	ELISA	ELISA	NNP
cord-015021-pol2qm74	7654	7	and	and	CC
cord-015021-pol2qm74	7654	8	TNF	TNF	NNP
cord-015021-pol2qm74	7654	9	bioactiv'dy	bioactiv'dy	NNP
cord-015021-pol2qm74	7654	10	.	.	.
cord-015021-pol2qm74	7655	1	Systemic	systemic	JJ
cord-015021-pol2qm74	7655	2	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	7655	3	were	be	VBD
cord-015021-pol2qm74	7655	4	evaluated	evaluate	VBN
cord-015021-pol2qm74	7655	5	with	with	IN
cord-015021-pol2qm74	7655	6	indwelling	indwell	VBG
cord-015021-pol2qm74	7655	7	arterial	arterial	JJ
cord-015021-pol2qm74	7655	8	and	and	CC
cord-015021-pol2qm74	7655	9	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7655	10	artery	artery	NN
cord-015021-pol2qm74	7655	11	catheters	catheter	NNS
cord-015021-pol2qm74	7655	12	and	and	CC
cord-015021-pol2qm74	7655	13	radionuclide	radionuclide	NN
cord-015021-pol2qm74	7655	14	heart	heart	NN
cord-015021-pol2qm74	7655	15	scans	scan	NNS
cord-015021-pol2qm74	7655	16	and	and	CC
cord-015021-pol2qm74	7655	17	compared	compare	VBN
cord-015021-pol2qm74	7655	18	before	before	RB
cord-015021-pol2qm74	7655	19	and	and	CC
cord-015021-pol2qm74	7655	20	after	after	IN
cord-015021-pol2qm74	7655	21	fluid	fluid	JJ
cord-015021-pol2qm74	7655	22	loading	loading	NN
cord-015021-pol2qm74	7655	23	in	in	IN
cord-015021-pol2qm74	7655	24	subjects	subject	NNS
cord-015021-pol2qm74	7655	25	given	give	VBN
cord-015021-pol2qm74	7655	26	vehicle	vehicle	NN
cord-015021-pol2qm74	7655	27	with	with	IN
cord-015021-pol2qm74	7655	28	HD	HD	NNP
cord-015021-pol2qm74	7655	29	TNFR	TNFR	NNP
cord-015021-pol2qm74	7655	30	:	:	:
cord-015021-pol2qm74	7656	1	Fc	Fc	NNP
cord-015021-pol2qm74	7656	2	.	.	.
cord-015021-pol2qm74	7657	1	Results	result	NNS
cord-015021-pol2qm74	7657	2	:	:	:
cord-015021-pol2qm74	7658	1	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	7658	2	-	-	HYPH
cord-015021-pol2qm74	7658	3	related	relate	VBN
cord-015021-pol2qm74	7658	4	symptoms	symptom	NNS
cord-015021-pol2qm74	7658	5	were	be	VBD
cord-015021-pol2qm74	7658	6	unchanged	unchanged	JJ
cord-015021-pol2qm74	7658	7	after	after	IN
cord-015021-pol2qm74	7658	8	LD	LD	NNP
cord-015021-pol2qm74	7658	9	or	or	CC
cord-015021-pol2qm74	7658	10	HD	HD	NNP
cord-015021-pol2qm74	7658	11	.	.	.
cord-015021-pol2qm74	7659	1	Peak	peak	NN
cord-015021-pol2qm74	7659	2	temperature	temperature	NN
cord-015021-pol2qm74	7659	3	occurred	occur	VBD
cord-015021-pol2qm74	7659	4	at	at	IN
cord-015021-pol2qm74	7659	5	a	a	DT
cord-015021-pol2qm74	7659	6	later	later	JJ
cord-015021-pol2qm74	7659	7	time	time	NN
cord-015021-pol2qm74	7659	8	point	point	NN
cord-015021-pol2qm74	7659	9	(	(	-LRB-
cord-015021-pol2qm74	7659	10	4	4	CD
cord-015021-pol2qm74	7659	11	-	-	SYM
cord-015021-pol2qm74	7659	12	5h	5h	CD
cord-015021-pol2qm74	7659	13	)	)	-RRB-
cord-015021-pol2qm74	7659	14	in	in	IN
cord-015021-pol2qm74	7659	15	subjects	subject	NNS
cord-015021-pol2qm74	7659	16	given	give	VBN
cord-015021-pol2qm74	7659	17	TNFR	TNFR	NNP
cord-015021-pol2qm74	7659	18	:	:	:
cord-015021-pol2qm74	7660	1	Fc	Fc	NNP
cord-015021-pol2qm74	7660	2	compared	compare	VBN
cord-015021-pol2qm74	7660	3	to	to	IN
cord-015021-pol2qm74	7660	4	vehicle	vehicle	NN
cord-015021-pol2qm74	7660	5	(	(	-LRB-
cord-015021-pol2qm74	7660	6	3h	3h	CD
cord-015021-pol2qm74	7660	7	)	)	-RRB-
cord-015021-pol2qm74	7660	8	(	(	-LRB-
cord-015021-pol2qm74	7660	9	p=.004	p=.004	NNP
cord-015021-pol2qm74	7660	10	)	)	-RRB-
cord-015021-pol2qm74	7660	11	.	.	.
cord-015021-pol2qm74	7661	1	At	at	IN
cord-015021-pol2qm74	7661	2	3h	3h	CD
cord-015021-pol2qm74	7661	3	,	,	,
cord-015021-pol2qm74	7661	4	5h	5h	NNP
cord-015021-pol2qm74	7661	5	(	(	-LRB-
cord-015021-pol2qm74	7661	6	post	post	JJ
cord-015021-pol2qm74	7661	7	fluid	fluid	JJ
cord-015021-pol2qm74	7661	8	load	load	NN
cord-015021-pol2qm74	7661	9	)	)	-RRB-
cord-015021-pol2qm74	7661	10	,	,	,
cord-015021-pol2qm74	7661	11	and	and	CC
cord-015021-pol2qm74	7661	12	8h	8h	NNP
cord-015021-pol2qm74	7661	13	,	,	,
cord-015021-pol2qm74	7661	14	subjects	subject	NNS
cord-015021-pol2qm74	7661	15	given	give	VBN
cord-015021-pol2qm74	7661	16	vehicle	vehicle	NN
cord-015021-pol2qm74	7661	17	developed	develop	VBD
cord-015021-pol2qm74	7661	18	increased	increase	VBN
cord-015021-pol2qm74	7661	19	cardiac	cardiac	JJ
cord-015021-pol2qm74	7661	20	index	index	NN
cord-015021-pol2qm74	7661	21	and	and	CC
cord-015021-pol2qm74	7661	22	heart	heart	NN
cord-015021-pol2qm74	7661	23	rate	rate	NN
cord-015021-pol2qm74	7661	24	and	and	CC
cord-015021-pol2qm74	7661	25	decreased	decrease	VBD
cord-015021-pol2qm74	7661	26	systemic	systemic	JJ
cord-015021-pol2qm74	7661	27	vascular	vascular	JJ
cord-015021-pol2qm74	7661	28	resistance	resistance	NN
cord-015021-pol2qm74	7661	29	index	index	NN
cord-015021-pol2qm74	7661	30	(	(	-LRB-
cord-015021-pol2qm74	7661	31	all	all	DT
cord-015021-pol2qm74	7661	32	p=.0001	p=.0001	JJ
cord-015021-pol2qm74	7661	33	)	)	-RRB-
cord-015021-pol2qm74	7661	34	.	.	.
cord-015021-pol2qm74	7662	1	HD	HD	NNP
cord-015021-pol2qm74	7662	2	TNFR	TNFR	NNP
cord-015021-pol2qm74	7662	3	:	:	:
cord-015021-pol2qm74	7663	1	Fc	Fc	NNP
cord-015021-pol2qm74	7663	2	did	do	VBD
cord-015021-pol2qm74	7663	3	not	not	RB
cord-015021-pol2qm74	7663	4	alter	alter	VB
cord-015021-pol2qm74	7663	5	this	this	DT
cord-015021-pol2qm74	7663	6	hyperdynamic	hyperdynamic	JJ
cord-015021-pol2qm74	7663	7	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	7663	8	response	response	NN
cord-015021-pol2qm74	7663	9	.	.	.
cord-015021-pol2qm74	7664	1	LD	LD	NNP
cord-015021-pol2qm74	7664	2	and	and	CC
cord-015021-pol2qm74	7664	3	HD	HD	NNP
cord-015021-pol2qm74	7664	4	inhibited	inhibit	VBD
cord-015021-pol2qm74	7664	5	the	the	DT
cord-015021-pol2qm74	7664	6	E	e	NN
cord-015021-pol2qm74	7664	7	-	-	HYPH
cord-015021-pol2qm74	7664	8	induced	induce	VBN
cord-015021-pol2qm74	7664	9	teukopenta	teukopenta	NN
cord-015021-pol2qm74	7664	10	at	at	IN
cord-015021-pol2qm74	7664	11	I	-PRON-	PRP
cord-015021-pol2qm74	7665	1	h	h	NNP
cord-015021-pol2qm74	7665	2	post	post	NN
cord-015021-pol2qm74	7665	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7665	4	(	(	-LRB-
cord-015021-pol2qm74	7665	5	p<.03	p<.03	NNP
cord-015021-pol2qm74	7665	6	)	)	-RRB-
cord-015021-pol2qm74	7665	7	and	and	CC
cord-015021-pol2qm74	7665	8	later	later	RB
cord-015021-pol2qm74	7665	9	leukocytosis	leukocytosis	NNP
cord-015021-pol2qm74	7665	10	(	(	-LRB-
cord-015021-pol2qm74	7665	11	p<0.05	p<0.05	NNP
cord-015021-pol2qm74	7665	12	)	)	-RRB-
cord-015021-pol2qm74	7665	13	.	.	.
cord-015021-pol2qm74	7666	1	Peak	Peak	NNP
cord-015021-pol2qm74	7666	2	TNF	TNF	NNP
cord-015021-pol2qm74	7666	3	bioactivity	bioactivity	NN
cord-015021-pol2qm74	7666	4	in	in	IN
cord-015021-pol2qm74	7666	5	subjects	subject	NNS
cord-015021-pol2qm74	7666	6	given	give	VBN
cord-015021-pol2qm74	7666	7	vehicle	vehicle	NN
cord-015021-pol2qm74	7666	8	was	be	VBD
cord-015021-pol2qm74	7666	9	154	154	CD
cord-015021-pol2qm74	7666	10	+	+	SYM
cord-015021-pol2qm74	7666	11	44	44	CD
cord-015021-pol2qm74	7666	12	pg	pg	NN
cord-015021-pol2qm74	7666	13	/	/	SYM
cord-015021-pol2qm74	7666	14	mL	ml	NN
cord-015021-pol2qm74	7666	15	and	and	CC
cord-015021-pol2qm74	7666	16	<	<	XX
cord-015021-pol2qm74	7666	17	10	10	CD
cord-015021-pol2qm74	7666	18	pg	pg	NN
cord-015021-pol2qm74	7666	19	/	/	SYM
cord-015021-pol2qm74	7666	20	mL	ml	NN
cord-015021-pol2qm74	7666	21	in	in	IN
cord-015021-pol2qm74	7666	22	the	the	DT
cord-015021-pol2qm74	7666	23	LD	LD	NNP
cord-015021-pol2qm74	7666	24	or	or	CC
cord-015021-pol2qm74	7666	25	HD	HD	NNP
cord-015021-pol2qm74	7666	26	TNFR	TNFR	NNP
cord-015021-pol2qm74	7666	27	:	:	:
cord-015021-pol2qm74	7667	1	Fc	Fc	NNP
cord-015021-pol2qm74	7667	2	groups	group	NNS
cord-015021-pol2qm74	7667	3	(	(	-LRB-
cord-015021-pol2qm74	7667	4	p<.001	p<.001	NNP
cord-015021-pol2qm74	7667	5	)	)	-RRB-
cord-015021-pol2qm74	7667	6	.	.	.
cord-015021-pol2qm74	7668	1	Two	two	CD
cord-015021-pol2qm74	7668	2	immunoassays	immunoassay	NNS
cord-015021-pol2qm74	7668	3	for	for	IN
cord-015021-pol2qm74	7668	4	TNF	TNF	NNP
cord-015021-pol2qm74	7668	5	were	be	VBD
cord-015021-pol2qm74	7668	6	performed	perform	VBN
cord-015021-pol2qm74	7668	7	because	because	IN
cord-015021-pol2qm74	7668	8	the	the	DT
cord-015021-pol2qm74	7668	9	detection	detection	NN
cord-015021-pol2qm74	7668	10	of	of	IN
cord-015021-pol2qm74	7668	11	receptor	receptor	NN
cord-015021-pol2qm74	7668	12	bound	bind	VBN
cord-015021-pol2qm74	7668	13	TNF	TNF	NNP
cord-015021-pol2qm74	7668	14	varies	vary	VBZ
cord-015021-pol2qm74	7668	15	with	with	IN
cord-015021-pol2qm74	7668	16	ELISA	ELISA	NNP
cord-015021-pol2qm74	7668	17	.	.	.
cord-015021-pol2qm74	7669	1	TNF	TNF	NNP
cord-015021-pol2qm74	7669	2	(	(	-LRB-
cord-015021-pol2qm74	7669	3	Biosource	Biosource	NNP
cord-015021-pol2qm74	7669	4	)	)	-RRB-
cord-015021-pol2qm74	7669	5	was	be	VBD
cord-015021-pol2qm74	7669	6	decreased	decrease	VBN
cord-015021-pol2qm74	7669	7	in	in	IN
cord-015021-pol2qm74	7669	8	LD	LD	NNP
cord-015021-pol2qm74	7669	9	vs	vs	IN
cord-015021-pol2qm74	7669	10	vehicle	vehicle	NN
cord-015021-pol2qm74	7669	11	or	or	CC
cord-015021-pol2qm74	7669	12	HD	hd	NN
cord-015021-pol2qm74	7669	13	(	(	-LRB-
cord-015021-pol2qm74	7669	14	p=.0001	p=.0001	NNP
cord-015021-pol2qm74	7669	15	)	)	-RRB-
cord-015021-pol2qm74	7669	16	whereas	whereas	IN
cord-015021-pol2qm74	7669	17	TNF	TNF	NNP
cord-015021-pol2qm74	7669	18	(	(	-LRB-
cord-015021-pol2qm74	7669	19	R&D	R&D	NNP
cord-015021-pol2qm74	7669	20	Systems	Systems	NNPS
cord-015021-pol2qm74	7669	21	)	)	-RRB-
cord-015021-pol2qm74	7669	22	was	be	VBD
cord-015021-pol2qm74	7669	23	increased	increase	VBN
cord-015021-pol2qm74	7669	24	after	after	IN
cord-015021-pol2qm74	7669	25	HD	hd	NN
cord-015021-pol2qm74	7669	26	or	or	CC
cord-015021-pol2qm74	7669	27	LD	LD	NNP
cord-015021-pol2qm74	7669	28	vs	vs	IN
cord-015021-pol2qm74	7669	29	vehicle	vehicle	NN
cord-015021-pol2qm74	7669	30	(	(	-LRB-
cord-015021-pol2qm74	7669	31	p<.001	p<.001	NNP
cord-015021-pol2qm74	7669	32	)	)	-RRB-
cord-015021-pol2qm74	7669	33	.	.	.
cord-015021-pol2qm74	7670	1	Decreased	decrease	VBN
cord-015021-pol2qm74	7670	2	levels	level	NNS
cord-015021-pol2qm74	7670	3	of	of	IN
cord-015021-pol2qm74	7670	4	IL-8	IL-8	NNP
cord-015021-pol2qm74	7670	5	(	(	-LRB-
cord-015021-pol2qm74	7670	6	p=.00	p=.00	CD
cord-015021-pol2qm74	7670	7	t	t	NN
cord-015021-pol2qm74	7670	8	)	)	-RRB-
cord-015021-pol2qm74	7670	9	,	,	,
cord-015021-pol2qm74	7670	10	granulocyte	granulocyte	NN
cord-015021-pol2qm74	7670	11	colony	colony	NN
cord-015021-pol2qm74	7670	12	stimulating	stimulate	VBG
cord-015021-pol2qm74	7670	13	factor	factor	NN
cord-015021-pol2qm74	7670	14	(	(	-LRB-
cord-015021-pol2qm74	7670	15	p=.03	p=.03	NN
cord-015021-pol2qm74	7670	16	)	)	-RRB-
cord-015021-pol2qm74	7670	17	,	,	,
cord-015021-pol2qm74	7670	18	and	and	CC
cord-015021-pol2qm74	7670	19	IL-1	IL-1	NNP
cord-015021-pol2qm74	7670	20	receptor	receptor	NN
cord-015021-pol2qm74	7670	21	antagonist	antagonist	NN
cord-015021-pol2qm74	7670	22	(	(	-LRB-
cord-015021-pol2qm74	7670	23	p=.001	p=.001	NNP
cord-015021-pol2qm74	7670	24	)	)	-RRB-
cord-015021-pol2qm74	7670	25	were	be	VBD
cord-015021-pol2qm74	7670	26	found	find	VBN
cord-015021-pol2qm74	7670	27	after	after	IN
cord-015021-pol2qm74	7670	28	LD	LD	NNP
cord-015021-pol2qm74	7670	29	or	or	CC
cord-015021-pol2qm74	7670	30	HD	HD	NNP
cord-015021-pol2qm74	7670	31	vs	vs	IN
cord-015021-pol2qm74	7670	32	vehicle	vehicle	NN
cord-015021-pol2qm74	7670	33	.	.	.
cord-015021-pol2qm74	7671	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	7671	2	levels	level	NNS
cord-015021-pol2qm74	7671	3	were	be	VBD
cord-015021-pol2qm74	7671	4	lower	low	JJR
cord-015021-pol2qm74	7671	5	after	after	IN
cord-015021-pol2qm74	7671	6	LD	LD	NNP
cord-015021-pol2qm74	7671	7	vs	vs	IN
cord-015021-pol2qm74	7671	8	vehicle	vehicle	NN
cord-015021-pol2qm74	7671	9	or	or	CC
cord-015021-pol2qm74	7671	10	HD	hd	NN
cord-015021-pol2qm74	7671	11	(	(	-LRB-
cord-015021-pol2qm74	7671	12	p=.006	p=.006	NNP
cord-015021-pol2qm74	7671	13	)	)	-RRB-
cord-015021-pol2qm74	7671	14	.	.	.
cord-015021-pol2qm74	7672	1	IL-10	IL-10	NNP
cord-015021-pol2qm74	7672	2	levels	level	NNS
cord-015021-pol2qm74	7672	3	were	be	VBD
cord-015021-pol2qm74	7672	4	similar	similar	JJ
cord-015021-pol2qm74	7672	5	among	among	IN
cord-015021-pol2qm74	7672	6	subjects	subject	NNS
cord-015021-pol2qm74	7672	7	given	give	VBN
cord-015021-pol2qm74	7672	8	vehicle	vehicle	NN
cord-015021-pol2qm74	7672	9	,	,	,
cord-015021-pol2qm74	7672	10	LD	LD	NNP
cord-015021-pol2qm74	7672	11	,	,	,
cord-015021-pol2qm74	7672	12	and	and	CC
cord-015021-pol2qm74	7672	13	HD	HD	NNP
cord-015021-pol2qm74	7672	14	TNFR	TNFR	NNP
cord-015021-pol2qm74	7672	15	:	:	:
cord-015021-pol2qm74	7673	1	Fc	Fc	NNP
cord-015021-pol2qm74	7673	2	.	.	.
cord-015021-pol2qm74	7674	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	7674	2	:	:	:
cord-015021-pol2qm74	7675	1	LD	LD	NNP
cord-015021-pol2qm74	7675	2	and	and	CC
cord-015021-pol2qm74	7675	3	HD	HD	NNP
cord-015021-pol2qm74	7675	4	TNFR	TNFR	NNP
cord-015021-pol2qm74	7675	5	:	:	:
cord-015021-pol2qm74	7676	1	Fc	Fc	NNP
cord-015021-pol2qm74	7676	2	delayed	delay	VBD
cord-015021-pol2qm74	7676	3	the	the	DT
cord-015021-pol2qm74	7676	4	febrile	febrile	JJ
cord-015021-pol2qm74	7676	5	response	response	NN
cord-015021-pol2qm74	7676	6	to	to	IN
cord-015021-pol2qm74	7676	7	E	e	NN
cord-015021-pol2qm74	7676	8	but	but	CC
cord-015021-pol2qm74	7676	9	did	do	VBD
cord-015021-pol2qm74	7676	10	not	not	RB
cord-015021-pol2qm74	7676	11	alter	alter	VB
cord-015021-pol2qm74	7676	12	the	the	DT
cord-015021-pol2qm74	7676	13	early	early	JJ
cord-015021-pol2qm74	7676	14	hyperdynamic	hyperdynamic	JJ
cord-015021-pol2qm74	7676	15	cardiac	cardiac	JJ
cord-015021-pol2qm74	7676	16	response	response	NN
cord-015021-pol2qm74	7676	17	.	.	.
cord-015021-pol2qm74	7677	1	This	this	DT
cord-015021-pol2qm74	7677	2	suggests	suggest	VBZ
cord-015021-pol2qm74	7677	3	that	that	IN
cord-015021-pol2qm74	7677	4	mediators	mediator	NNS
cord-015021-pol2qm74	7677	5	other	other	JJ
cord-015021-pol2qm74	7677	6	than	than	IN
cord-015021-pol2qm74	7677	7	TNF	TNF	NNP
cord-015021-pol2qm74	7677	8	play	play	VBP
cord-015021-pol2qm74	7677	9	an	an	DT
cord-015021-pol2qm74	7677	10	important	important	JJ
cord-015021-pol2qm74	7677	11	role	role	NN
cord-015021-pol2qm74	7677	12	in	in	IN
cord-015021-pol2qm74	7677	13	the	the	DT
cord-015021-pol2qm74	7677	14	initial	initial	JJ
cord-015021-pol2qm74	7677	15	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	7677	16	response	response	NN
cord-015021-pol2qm74	7677	17	to	to	IN
cord-015021-pol2qm74	7677	18	E	e	NN
cord-015021-pol2qm74	7677	19	in	in	IN
cord-015021-pol2qm74	7677	20	humans	human	NNS
cord-015021-pol2qm74	7677	21	.	.	.
cord-015021-pol2qm74	7678	1	TNFR	TNFR	NNP
cord-015021-pol2qm74	7678	2	:	:	:
cord-015021-pol2qm74	7679	1	Fc	Fc	NNP
cord-015021-pol2qm74	7679	2	attenuated	attenuate	VBD
cord-015021-pol2qm74	7679	3	the	the	DT
cord-015021-pol2qm74	7679	4	release	release	NN
cord-015021-pol2qm74	7679	5	of	of	IN
cord-015021-pol2qm74	7679	6	some	some	DT
cord-015021-pol2qm74	7679	7	E	e	NN
cord-015021-pol2qm74	7679	8	and	and	CC
cord-015021-pol2qm74	7679	9	TNF	tnf	NN
cord-015021-pol2qm74	7679	10	-	-	HYPH
cord-015021-pol2qm74	7679	11	induced	induce	VBN
cord-015021-pol2qm74	7679	12	cytokines	cytokine	NNS
cord-015021-pol2qm74	7679	13	.	.	.
cord-015021-pol2qm74	7680	1	Ti	Ti	NNP
cord-015021-pol2qm74	7681	1	~e	~e	NFP
cord-015021-pol2qm74	7681	2	antiinflammatory	antiinflammatory	JJ
cord-015021-pol2qm74	7681	3	responses	response	NNS
cord-015021-pol2qm74	7681	4	of	of	IN
cord-015021-pol2qm74	7681	5	TNFR	TNFR	NNP
cord-015021-pol2qm74	7681	6	:	:	:
cord-015021-pol2qm74	7682	1	Fc	Fc	NNP
cord-015021-pol2qm74	7682	2	may	may	MD
cord-015021-pol2qm74	7682	3	be	be	VB
cord-015021-pol2qm74	7682	4	useful	useful	JJ
cord-015021-pol2qm74	7682	5	in	in	IN
cord-015021-pol2qm74	7682	6	some	some	DT
cord-015021-pol2qm74	7682	7	patients	patient	NNS
cord-015021-pol2qm74	7682	8	with	with	IN
cord-015021-pol2qm74	7682	9	disease	disease	NN
cord-015021-pol2qm74	7682	10	processes	process	NNS
cord-015021-pol2qm74	7682	11	resulting	result	VBG
cord-015021-pol2qm74	7682	12	from	from	IN
cord-015021-pol2qm74	7682	13	excessive	excessive	JJ
cord-015021-pol2qm74	7682	14	TNF	tnf	NN
cord-015021-pol2qm74	7682	15	-	-	HYPH
cord-015021-pol2qm74	7682	16	mediated	mediate	VBN
cord-015021-pol2qm74	7682	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7682	18	responses	response	NNS
cord-015021-pol2qm74	7682	19	.	.	.
cord-015021-pol2qm74	7683	1	The	the	DT
cord-015021-pol2qm74	7683	2	biosynthesis	biosynthesis	NN
cord-015021-pol2qm74	7683	3	of	of	IN
cord-015021-pol2qm74	7683	4	TNF	TNF	NNP
cord-015021-pol2qm74	7683	5	within	within	IN
cord-015021-pol2qm74	7683	6	macrophages	macrophage	NNS
cord-015021-pol2qm74	7683	7	is	be	VBZ
cord-015021-pol2qm74	7683	8	regulated	regulate	VBN
cord-015021-pol2qm74	7683	9	both	both	CC
cord-015021-pol2qm74	7683	10	at	at	IN
cord-015021-pol2qm74	7683	11	the	the	DT
cord-015021-pol2qm74	7683	12	transcriptional	transcriptional	NN
cord-015021-pol2qm74	7683	13	and	and	CC
cord-015021-pol2qm74	7683	14	the	the	DT
cord-015021-pol2qm74	7683	15	translational	translational	JJ
cord-015021-pol2qm74	7683	16	levels	level	NNS
cord-015021-pol2qm74	7683	17	.	.	.
cord-015021-pol2qm74	7684	1	The	the	DT
cord-015021-pol2qm74	7684	2	5	5	CD
cord-015021-pol2qm74	7684	3	'	'	POS
cord-015021-pol2qm74	7684	4	flanking	flank	VBG
cord-015021-pol2qm74	7684	5	region	region	NN
cord-015021-pol2qm74	7684	6	of	of	IN
cord-015021-pol2qm74	7684	7	the	the	DT
cord-015021-pol2qm74	7684	8	TNF	TNF	NNP
cord-015021-pol2qm74	7684	9	gene	gene	NN
cord-015021-pol2qm74	7684	10	contains	contain	VBZ
cord-015021-pol2qm74	7684	11	several	several	JJ
cord-015021-pol2qm74	7684	12	transcriptional	transcriptional	JJ
cord-015021-pol2qm74	7684	13	control	control	NN
cord-015021-pol2qm74	7684	14	elements	element	NNS
cord-015021-pol2qm74	7684	15	,	,	,
cord-015021-pol2qm74	7684	16	including	include	VBG
cord-015021-pol2qm74	7684	17	two	two	CD
cord-015021-pol2qm74	7684	18	KB	KB	NNP
cord-015021-pol2qm74	7684	19	enhancers	enhancer	NNS
cord-015021-pol2qm74	7684	20	similar	similar	JJ
cord-015021-pol2qm74	7684	21	to	to	IN
cord-015021-pol2qm74	7684	22	those	those	DT
cord-015021-pol2qm74	7684	23	of	of	IN
cord-015021-pol2qm74	7684	24	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	7684	25	genes	gene	NNS
cord-015021-pol2qm74	7684	26	and	and	CC
cord-015021-pol2qm74	7684	27	a	a	DT
cord-015021-pol2qm74	7684	28	"	"	``
cord-015021-pol2qm74	7684	29	Y	Y	NNP
cord-015021-pol2qm74	7684	30	box	box	NN
cord-015021-pol2qm74	7684	31	"	"	''
cord-015021-pol2qm74	7684	32	similar	similar	JJ
cord-015021-pol2qm74	7684	33	to	to	IN
cord-015021-pol2qm74	7684	34	that	that	DT
cord-015021-pol2qm74	7684	35	of	of	IN
cord-015021-pol2qm74	7684	36	the	the	DT
cord-015021-pol2qm74	7684	37	MHC	MHC	NNP
cord-015021-pol2qm74	7684	38	class	class	NN
cord-015021-pol2qm74	7684	39	II	II	NNP
cord-015021-pol2qm74	7684	40	promoter	promoter	NN
cord-015021-pol2qm74	7684	41	.	.	.
cord-015021-pol2qm74	7685	1	These	these	DT
cord-015021-pol2qm74	7685	2	elements	element	NNS
cord-015021-pol2qm74	7685	3	are	be	VBP
cord-015021-pol2qm74	7685	4	critical	critical	JJ
cord-015021-pol2qm74	7685	5	for	for	IN
cord-015021-pol2qm74	7685	6	the	the	DT
cord-015021-pol2qm74	7685	7	enhancement	enhancement	NN
cord-015021-pol2qm74	7685	8	of	of	IN
cord-015021-pol2qm74	7685	9	transcription	transcription	NN
cord-015021-pol2qm74	7685	10	noted	note	VBN
cord-015021-pol2qm74	7685	11	after	after	IN
cord-015021-pol2qm74	7685	12	stimulation	stimulation	NN
cord-015021-pol2qm74	7685	13	of	of	IN
cord-015021-pol2qm74	7685	14	macrophages	macrophage	NNS
cord-015021-pol2qm74	7685	15	with	with	IN
cord-015021-pol2qm74	7685	16	LPS	lp	NNS
cord-015021-pol2qm74	7685	17	.	.	.
cord-015021-pol2qm74	7686	1	Despite	despite	IN
cord-015021-pol2qm74	7686	2	these	these	DT
cord-015021-pol2qm74	7686	3	and	and	CC
cord-015021-pol2qm74	7686	4	other	other	JJ
cord-015021-pol2qm74	7686	5	elements	element	NNS
cord-015021-pol2qm74	7686	6	,	,	,
cord-015021-pol2qm74	7686	7	transcriptional	transcriptional	JJ
cord-015021-pol2qm74	7686	8	regulation	regulation	NN
cord-015021-pol2qm74	7686	9	alone	alone	RB
cord-015021-pol2qm74	7686	10	accounts	account	VBZ
cord-015021-pol2qm74	7686	11	neither	neither	CC
cord-015021-pol2qm74	7686	12	for	for	IN
cord-015021-pol2qm74	7686	13	the	the	DT
cord-015021-pol2qm74	7686	14	absence	absence	NN
cord-015021-pol2qm74	7686	15	of	of	IN
cord-015021-pol2qm74	7686	16	TNF	TNF	NNP
cord-015021-pol2qm74	7686	17	protein	protein	NN
cord-015021-pol2qm74	7686	18	during	during	IN
cord-015021-pol2qm74	7686	19	normal	normal	JJ
cord-015021-pol2qm74	7686	20	homeostasis	homeostasis	NN
cord-015021-pol2qm74	7686	21	nor	nor	CC
cord-015021-pol2qm74	7686	22	the	the	DT
cord-015021-pol2qm74	7686	23	profound	profound	JJ
cord-015021-pol2qm74	7686	24	increasein	increasein	JJ
cord-015021-pol2qm74	7686	25	TNF	TNF	NNP
cord-015021-pol2qm74	7686	26	production	production	NN
cord-015021-pol2qm74	7686	27	following	follow	VBG
cord-015021-pol2qm74	7686	28	stimulation	stimulation	NN
cord-015021-pol2qm74	7686	29	with	with	IN
cord-015021-pol2qm74	7686	30	LPS	LPS	NNP
cord-015021-pol2qm74	7686	31	or	or	CC
cord-015021-pol2qm74	7686	32	other	other	JJ
cord-015021-pol2qm74	7686	33	secretagogues	secretagogue	NNS
cord-015021-pol2qm74	7686	34	.	.	.
cord-015021-pol2qm74	7687	1	The	the	DT
cord-015021-pol2qm74	7687	2	translation	translation	NN
cord-015021-pol2qm74	7687	3	of	of	IN
cord-015021-pol2qm74	7687	4	TNF	TNF	NNP
cord-015021-pol2qm74	7687	5	mRNA	mRNA	NNP
cord-015021-pol2qm74	7687	6	into	into	IN
cord-015021-pol2qm74	7687	7	protein	protein	NN
cord-015021-pol2qm74	7687	8	is	be	VBZ
cord-015021-pol2qm74	7687	9	also	also	RB
cord-015021-pol2qm74	7687	10	tightly	tightly	RB
cord-015021-pol2qm74	7687	11	regulated	regulate	VBN
cord-015021-pol2qm74	7687	12	via	via	IN
cord-015021-pol2qm74	7687	13	mechanisms	mechanism	NNS
cord-015021-pol2qm74	7687	14	involving	involve	VBG
cord-015021-pol2qm74	7687	15	the	the	DT
cord-015021-pol2qm74	7687	16	octameric	octameric	JJ
cord-015021-pol2qm74	7687	17	"	"	``
cord-015021-pol2qm74	7687	18	TTATTTAT	ttatttat	NN
cord-015021-pol2qm74	7687	19	"	"	''
cord-015021-pol2qm74	7687	20	motif	motif	NN
cord-015021-pol2qm74	7687	21	present	present	JJ
cord-015021-pol2qm74	7687	22	in	in	IN
cord-015021-pol2qm74	7687	23	the	the	DT
cord-015021-pol2qm74	7687	24	3'untranslated	3'untranslated	CD
cord-015021-pol2qm74	7687	25	region	region	NN
cord-015021-pol2qm74	7687	26	of	of	IN
cord-015021-pol2qm74	7687	27	TNF	TNF	NNP
cord-015021-pol2qm74	7687	28	,	,	,
cord-015021-pol2qm74	7687	29	human	human	JJ
cord-015021-pol2qm74	7687	30	inducible	inducible	JJ
cord-015021-pol2qm74	7687	31	NO	no	DT
cord-015021-pol2qm74	7687	32	synthase	synthase	NN
cord-015021-pol2qm74	7687	33	,	,	,
cord-015021-pol2qm74	7687	34	and	and	CC
cord-015021-pol2qm74	7687	35	several	several	JJ
cord-015021-pol2qm74	7687	36	other	other	JJ
cord-015021-pol2qm74	7687	37	cytokine	cytokine	NN
cord-015021-pol2qm74	7687	38	genes	gene	NNS
cord-015021-pol2qm74	7687	39	.	.	.
cord-015021-pol2qm74	7688	1	This	this	DT
cord-015021-pol2qm74	7688	2	region	region	NN
cord-015021-pol2qm74	7688	3	not	not	RB
cord-015021-pol2qm74	7688	4	only	only	RB
cord-015021-pol2qm74	7688	5	destabilizes	destabilize	VBZ
cord-015021-pol2qm74	7688	6	mRNA	mrna	NN
cord-015021-pol2qm74	7688	7	,	,	,
cord-015021-pol2qm74	7688	8	but	but	CC
cord-015021-pol2qm74	7688	9	also	also	RB
cord-015021-pol2qm74	7688	10	confers	confer	VBZ
cord-015021-pol2qm74	7688	11	a	a	DT
cord-015021-pol2qm74	7688	12	translational	translational	JJ
cord-015021-pol2qm74	7688	13	blockade	blockade	NN
cord-015021-pol2qm74	7688	14	so	so	IN
cord-015021-pol2qm74	7688	15	that	that	IN
cord-015021-pol2qm74	7688	16	TNF	TNF	NNP
cord-015021-pol2qm74	7688	17	protein	protein	NN
cord-015021-pol2qm74	7688	18	is	be	VBZ
cord-015021-pol2qm74	7688	19	not	not	RB
cord-015021-pol2qm74	7688	20	normally	normally	RB
cord-015021-pol2qm74	7688	21	synthesized	synthesize	VBN
cord-015021-pol2qm74	7688	22	despite	despite	IN
cord-015021-pol2qm74	7688	23	leaky	leaky	JJ
cord-015021-pol2qm74	7688	24	basal	basal	NN
cord-015021-pol2qm74	7688	25	transcription	transcription	NN
cord-015021-pol2qm74	7688	26	.	.	.
cord-015021-pol2qm74	7689	1	LPS	LPS	NNP
cord-015021-pol2qm74	7689	2	stimulation	stimulation	NN
cord-015021-pol2qm74	7689	3	releases	release	VBZ
cord-015021-pol2qm74	7689	4	translational	translational	JJ
cord-015021-pol2qm74	7689	5	blockade	blockade	NN
cord-015021-pol2qm74	7689	6	and	and	CC
cord-015021-pol2qm74	7689	7	,	,	,
cord-015021-pol2qm74	7689	8	together	together	RB
cord-015021-pol2qm74	7689	9	with	with	IN
cord-015021-pol2qm74	7689	10	enhanced	enhance	VBN
cord-015021-pol2qm74	7689	11	trancriptional	trancriptional	JJ
cord-015021-pol2qm74	7689	12	rate	rate	NN
cord-015021-pol2qm74	7689	13	,	,	,
cord-015021-pol2qm74	7689	14	accounts	account	VBZ
cord-015021-pol2qm74	7689	15	for	for	IN
cord-015021-pol2qm74	7689	16	significantly	significantly	RB
cord-015021-pol2qm74	7689	17	increased	increase	VBN
cord-015021-pol2qm74	7689	18	TNF	TNF	NNP
cord-015021-pol2qm74	7689	19	secretion	secretion	NN
cord-015021-pol2qm74	7689	20	.	.	.
cord-015021-pol2qm74	7690	1	Opportunities	opportunity	NNS
cord-015021-pol2qm74	7690	2	for	for	IN
cord-015021-pol2qm74	7690	3	inhibition	inhibition	NN
cord-015021-pol2qm74	7690	4	of	of	IN
cord-015021-pol2qm74	7690	5	TNF	TNF	NNP
cord-015021-pol2qm74	7690	6	production	production	NN
cord-015021-pol2qm74	7690	7	are	be	VBP
cord-015021-pol2qm74	7690	8	available	available	JJ
cord-015021-pol2qm74	7690	9	at	at	IN
cord-015021-pol2qm74	7690	10	each	each	DT
cord-015021-pol2qm74	7690	11	of	of	IN
cord-015021-pol2qm74	7690	12	these	these	DT
cord-015021-pol2qm74	7690	13	two	two	CD
cord-015021-pol2qm74	7690	14	levels	level	NNS
cord-015021-pol2qm74	7690	15	.	.	.
cord-015021-pol2qm74	7691	1	Agents	agent	NNS
cord-015021-pol2qm74	7691	2	which	which	WDT
cord-015021-pol2qm74	7691	3	increase	increase	VBP
cord-015021-pol2qm74	7691	4	intracellular	intracellular	JJ
cord-015021-pol2qm74	7691	5	cAMP	camp	NN
cord-015021-pol2qm74	7692	1	(	(	-LRB-
cord-015021-pol2qm74	7692	2	pentoxif¥1ine	pentoxif¥1ine	``
cord-015021-pol2qm74	7692	3	,	,	,
cord-015021-pol2qm74	7692	4	amrinone	amrinone	NN
cord-015021-pol2qm74	7692	5	)	)	-RRB-
cord-015021-pol2qm74	7692	6	inhibit	inhibit	VBP
cord-015021-pol2qm74	7692	7	accumulation	accumulation	NN
cord-015021-pol2qm74	7692	8	of	of	IN
cord-015021-pol2qm74	7692	9	TNF	TNF	NNP
cord-015021-pol2qm74	7692	10	mRNA	mRNA	NNP
cord-015021-pol2qm74	7692	11	;	;	:
cord-015021-pol2qm74	7692	12	in	in	IN
cord-015021-pol2qm74	7692	13	contrast	contrast	NN
cord-015021-pol2qm74	7692	14	,	,	,
cord-015021-pol2qm74	7692	15	corticosteroids	corticosteroid	NNS
cord-015021-pol2qm74	7692	16	act	act	VBP
cord-015021-pol2qm74	7692	17	primarily	primarily	RB
cord-015021-pol2qm74	7692	18	at	at	IN
cord-015021-pol2qm74	7692	19	the	the	DT
cord-015021-pol2qm74	7692	20	level	level	NN
cord-015021-pol2qm74	7692	21	of	of	IN
cord-015021-pol2qm74	7692	22	translation	translation	NN
cord-015021-pol2qm74	7692	23	,	,	,
cord-015021-pol2qm74	7692	24	inhibiting	inhibit	VBG
cord-015021-pol2qm74	7692	25	LPS	LPS	NNP
cord-015021-pol2qm74	7692	26	induced	induce	VBD
cord-015021-pol2qm74	7692	27	translational	translational	JJ
cord-015021-pol2qm74	7692	28	activation	activation	NN
cord-015021-pol2qm74	7692	29	.	.	.
cord-015021-pol2qm74	7693	1	Understanding	understand	VBG
cord-015021-pol2qm74	7693	2	the	the	DT
cord-015021-pol2qm74	7693	3	regulation	regulation	NN
cord-015021-pol2qm74	7693	4	of	of	IN
cord-015021-pol2qm74	7693	5	TNF	TNF	NNP
cord-015021-pol2qm74	7693	6	biosynthesis	biosynthesis	NN
cord-015021-pol2qm74	7693	7	may	may	MD
cord-015021-pol2qm74	7693	8	assist	assist	VB
cord-015021-pol2qm74	7693	9	in	in	IN
cord-015021-pol2qm74	7693	10	clinical	clinical	JJ
cord-015021-pol2qm74	7693	11	strategies	strategy	NNS
cord-015021-pol2qm74	7693	12	designed	design	VBN
cord-015021-pol2qm74	7693	13	to	to	TO
cord-015021-pol2qm74	7693	14	regulate	regulate	VB
cord-015021-pol2qm74	7693	15	TNF	TNF	NNP
cord-015021-pol2qm74	7693	16	secretion	secretion	NN
cord-015021-pol2qm74	7693	17	.	.	.
cord-015021-pol2qm74	7694	1	The	the	DT
cord-015021-pol2qm74	7694	2	serine	serine	NN
cord-015021-pol2qm74	7694	3	protease	protease	NN
cord-015021-pol2qm74	7694	4	thrombin	thrombin	NN
cord-015021-pol2qm74	7694	5	is	be	VBZ
cord-015021-pol2qm74	7694	6	formed	form	VBN
cord-015021-pol2qm74	7694	7	by	by	IN
cord-015021-pol2qm74	7694	8	enzymatic	enzymatic	JJ
cord-015021-pol2qm74	7694	9	conversion	conversion	NN
cord-015021-pol2qm74	7694	10	from	from	IN
cord-015021-pol2qm74	7694	11	its	-PRON-	PRP$
cord-015021-pol2qm74	7694	12	proenzyme	proenzyme	NNS
cord-015021-pol2qm74	7694	13	form	form	NN
cord-015021-pol2qm74	7694	14	after	after	IN
cord-015021-pol2qm74	7694	15	coagulation	coagulation	NN
cord-015021-pol2qm74	7694	16	activation	activation	NN
cord-015021-pol2qm74	7694	17	and	and	CC
cord-015021-pol2qm74	7694	18	may	may	MD
cord-015021-pol2qm74	7694	19	enhance	enhance	VB
cord-015021-pol2qm74	7694	20	the	the	DT
cord-015021-pol2qm74	7694	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7694	22	response	response	NN
cord-015021-pol2qm74	7694	23	in	in	IN
cord-015021-pol2qm74	7694	24	various	various	JJ
cord-015021-pol2qm74	7694	25	ways	way	NNS
cord-015021-pol2qm74	7694	26	.	.	.
cord-015021-pol2qm74	7695	1	In	in	IN
cord-015021-pol2qm74	7695	2	the	the	DT
cord-015021-pol2qm74	7695	3	last	last	JJ
cord-015021-pol2qm74	7695	4	step	step	NN
cord-015021-pol2qm74	7695	5	of	of	IN
cord-015021-pol2qm74	7695	6	the	the	DT
cord-015021-pol2qm74	7695	7	coagulation	coagulation	NN
cord-015021-pol2qm74	7695	8	cascade	cascade	NN
cord-015021-pol2qm74	7695	9	,	,	,
cord-015021-pol2qm74	7695	10	thrombin	thrombin	NN
cord-015021-pol2qm74	7695	11	cleaves	cleave	VBZ
cord-015021-pol2qm74	7695	12	its	-PRON-	PRP$
cord-015021-pol2qm74	7695	13	substrate	substrate	NN
cord-015021-pol2qm74	7695	14	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	7695	15	,	,	,
cord-015021-pol2qm74	7695	16	thus	thus	RB
cord-015021-pol2qm74	7695	17	forming	form	VBG
cord-015021-pol2qm74	7695	18	fibrin	fibrin	NN
cord-015021-pol2qm74	7695	19	.	.	.
cord-015021-pol2qm74	7696	1	The	the	DT
cord-015021-pol2qm74	7696	2	fibrin	fibrin	NN
cord-015021-pol2qm74	7696	3	clot	clot	NN
cord-015021-pol2qm74	7696	4	may	may	MD
cord-015021-pol2qm74	7696	5	prevent	prevent	VB
cord-015021-pol2qm74	7696	6	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7696	7	of	of	IN
cord-015021-pol2qm74	7696	8	bacteria	bacteria	NNS
cord-015021-pol2qm74	7696	9	and	and	CC
cord-015021-pol2qm74	7696	10	promote	promote	VB
cord-015021-pol2qm74	7696	11	local	local	JJ
cord-015021-pol2qm74	7696	12	bacterial	bacterial	JJ
cord-015021-pol2qm74	7696	13	growth	growth	NN
cord-015021-pol2qm74	7696	14	.	.	.
cord-015021-pol2qm74	7697	1	Thrombin	Thrombin	NNP
cord-015021-pol2qm74	7697	2	can	can	MD
cord-015021-pol2qm74	7697	3	also	also	RB
cord-015021-pol2qm74	7697	4	stimulate	stimulate	VB
cord-015021-pol2qm74	7697	5	a	a	DT
cord-015021-pol2qm74	7697	6	specific	specific	JJ
cord-015021-pol2qm74	7697	7	th.rombin	th.rombin	NNP
cord-015021-pol2qm74	7697	8	receptor	receptor	NN
cord-015021-pol2qm74	7697	9	that	that	WDT
cord-015021-pol2qm74	7697	10	exists	exist	VBZ
cord-015021-pol2qm74	7697	11	on	on	IN
cord-015021-pol2qm74	7697	12	a	a	DT
cord-015021-pol2qm74	7697	13	variety	variety	NN
cord-015021-pol2qm74	7697	14	of	of	IN
cord-015021-pol2qm74	7697	15	cells	cell	NNS
cord-015021-pol2qm74	7697	16	.	.	.
cord-015021-pol2qm74	7698	1	For	for	IN
cord-015021-pol2qm74	7698	2	example	example	NN
cord-015021-pol2qm74	7698	3	,	,	,
cord-015021-pol2qm74	7698	4	minute	minute	NN
cord-015021-pol2qm74	7698	5	amounts	amount	NNS
cord-015021-pol2qm74	7698	6	of	of	IN
cord-015021-pol2qm74	7698	7	thrombin	thrombin	NN
cord-015021-pol2qm74	7698	8	ma	ma	NNP
cord-015021-pol2qm74	7698	9	)	)	-RRB-
cord-015021-pol2qm74	7698	10	,	,	,
cord-015021-pol2qm74	7698	11	stimulate	stimulate	VBP
cord-015021-pol2qm74	7698	12	platelets	platelet	NNS
cord-015021-pol2qm74	7698	13	to	to	TO
cord-015021-pol2qm74	7698	14	develop	develop	VB
cord-015021-pol2qm74	7698	15	tissue	tissue	NN
cord-015021-pol2qm74	7698	16	factor	factor	NN
cord-015021-pol2qm74	7698	17	and	and	CC
cord-015021-pol2qm74	7698	18	boost	boost	VB
cord-015021-pol2qm74	7698	19	the	the	DT
cord-015021-pol2qm74	7698	20	activation	activation	NN
cord-015021-pol2qm74	7698	21	of	of	IN
cord-015021-pol2qm74	7698	22	more	more	RBR
cord-015021-pol2qm74	7698	23	thrombin	thrombin	NN
cord-015021-pol2qm74	7698	24	,	,	,
cord-015021-pol2qm74	7698	25	thus	thus	RB
cord-015021-pol2qm74	7698	26	initiating	initiate	VBG
cord-015021-pol2qm74	7698	27	a	a	DT
cord-015021-pol2qm74	7698	28	positive	positive	JJ
cord-015021-pol2qm74	7698	29	feedback	feedback	NN
cord-015021-pol2qm74	7698	30	loop	loop	NN
cord-015021-pol2qm74	7698	31	.	.	.
cord-015021-pol2qm74	7699	1	Other	other	JJ
cord-015021-pol2qm74	7699	2	cellular	cellular	JJ
cord-015021-pol2qm74	7699	3	effects	effect	NNS
cord-015021-pol2qm74	7699	4	of	of	IN
cord-015021-pol2qm74	7699	5	thrombin	thrombin	JJ
cord-015021-pol2qm74	7699	6	receptor	receptor	NN
cord-015021-pol2qm74	7699	7	stimulation	stimulation	NN
cord-015021-pol2qm74	7699	8	include	include	VBP
cord-015021-pol2qm74	7699	9	increase	increase	NN
cord-015021-pol2qm74	7699	10	in	in	IN
cord-015021-pol2qm74	7699	11	intracellular	intracellular	JJ
cord-015021-pol2qm74	7699	12	calcium	calcium	NN
cord-015021-pol2qm74	7699	13	of	of	IN
cord-015021-pol2qm74	7699	14	platelets	platelet	NNS
cord-015021-pol2qm74	7699	15	and	and	CC
cord-015021-pol2qm74	7699	16	monocytes	monocyte	NNS
cord-015021-pol2qm74	7699	17	,	,	,
cord-015021-pol2qm74	7699	18	contraction	contraction	NN
cord-015021-pol2qm74	7699	19	of	of	IN
cord-015021-pol2qm74	7699	20	smooth	smooth	JJ
cord-015021-pol2qm74	7699	21	muscle	muscle	NN
cord-015021-pol2qm74	7699	22	cells	cell	NNS
cord-015021-pol2qm74	7699	23	,	,	,
cord-015021-pol2qm74	7699	24	increase	increase	VBP
cord-015021-pol2qm74	7699	25	in	in	IN
cord-015021-pol2qm74	7699	26	endothelial	endothelial	JJ
cord-015021-pol2qm74	7699	27	permeability	permeability	NN
cord-015021-pol2qm74	7699	28	,	,	,
cord-015021-pol2qm74	7699	29	thromboxane	thromboxane	NN
cord-015021-pol2qm74	7699	30	generation	generation	NN
cord-015021-pol2qm74	7699	31	by	by	IN
cord-015021-pol2qm74	7699	32	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7699	33	and	and	CC
cord-015021-pol2qm74	7699	34	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	7699	35	,	,	,
cord-015021-pol2qm74	7699	36	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7699	37	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	7699	38	,	,	,
cord-015021-pol2qm74	7699	39	and	and	CC
cord-015021-pol2qm74	7699	40	enhanced	enhanced	JJ
cord-015021-pol2qm74	7699	41	cytokine	cytokine	NN
cord-015021-pol2qm74	7699	42	production	production	NN
cord-015021-pol2qm74	7699	43	.	.	.
cord-015021-pol2qm74	7700	1	Animal	animal	NN
cord-015021-pol2qm74	7700	2	experiments	experiment	NNS
cord-015021-pol2qm74	7700	3	have	have	VBP
cord-015021-pol2qm74	7700	4	been	be	VBN
cord-015021-pol2qm74	7700	5	conducted	conduct	VBN
cord-015021-pol2qm74	7700	6	with	with	IN
cord-015021-pol2qm74	7700	7	a	a	DT
cord-015021-pol2qm74	7700	8	variety	variety	NN
cord-015021-pol2qm74	7700	9	of	of	IN
cord-015021-pol2qm74	7700	10	thrombin	thrombin	NN
cord-015021-pol2qm74	7700	11	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	7700	12	including	include	VBG
cord-015021-pol2qm74	7700	13	heparin	heparin	VBN
cord-015021-pol2qm74	7700	14	,	,	,
cord-015021-pol2qm74	7700	15	antithrombin	antithrombin	NN
cord-015021-pol2qm74	7700	16	IlI	IlI	NNP
cord-015021-pol2qm74	7700	17	,	,	,
cord-015021-pol2qm74	7700	18	hiradin	hiradin	NNP
cord-015021-pol2qm74	7700	19	,	,	,
cord-015021-pol2qm74	7700	20	and	and	CC
cord-015021-pol2qm74	7700	21	hirudin	hirudin	NN
cord-015021-pol2qm74	7700	22	-	-	HYPH
cord-015021-pol2qm74	7700	23	like	like	JJ
cord-015021-pol2qm74	7700	24	peptides	peptide	NNS
cord-015021-pol2qm74	7700	25	.	.	.
cord-015021-pol2qm74	7701	1	An	an	DT
cord-015021-pol2qm74	7701	2	alternative	alternative	JJ
cord-015021-pol2qm74	7701	3	approach	approach	NN
cord-015021-pol2qm74	7701	4	is	be	VBZ
cord-015021-pol2qm74	7701	5	the	the	DT
cord-015021-pol2qm74	7701	6	inhibition	inhibition	NN
cord-015021-pol2qm74	7701	7	of	of	IN
cord-015021-pol2qm74	7701	8	the	the	DT
cord-015021-pol2qm74	7701	9	coagulation	coagulation	NN
cord-015021-pol2qm74	7701	10	cascade	cascade	NN
cord-015021-pol2qm74	7701	11	at	at	IN
cord-015021-pol2qm74	7701	12	an	an	DT
cord-015021-pol2qm74	7701	13	earlier	early	JJR
cord-015021-pol2qm74	7701	14	point	point	NN
cord-015021-pol2qm74	7701	15	in	in	IN
cord-015021-pol2qm74	7701	16	the	the	DT
cord-015021-pol2qm74	7701	17	cascades	cascade	NNS
cord-015021-pol2qm74	7701	18	,	,	,
cord-015021-pol2qm74	7701	19	or	or	CC
cord-015021-pol2qm74	7701	20	administration	administration	NN
cord-015021-pol2qm74	7701	21	of	of	IN
cord-015021-pol2qm74	7701	22	the	the	DT
cord-015021-pol2qm74	7701	23	anticoagulant	anticoagulant	JJ
cord-015021-pol2qm74	7701	24	enzyme	enzyme	NN
cord-015021-pol2qm74	7701	25	protein	protein	NN
cord-015021-pol2qm74	7701	26	C	C	NNP
cord-015021-pol2qm74	7701	27	Work	work	NN
cord-015021-pol2qm74	7701	28	from	from	IN
cord-015021-pol2qm74	7701	29	our	-PRON-	PRP$
cord-015021-pol2qm74	7701	30	own	own	JJ
cord-015021-pol2qm74	7701	31	group	group	NN
cord-015021-pol2qm74	7701	32	in	in	IN
cord-015021-pol2qm74	7701	33	a	a	DT
cord-015021-pol2qm74	7701	34	porcine	porcine	JJ
cord-015021-pol2qm74	7701	35	model	model	NN
cord-015021-pol2qm74	7701	36	of	of	IN
cord-015021-pol2qm74	7701	37	lipopolysaccharide-(LPS)-induced	lipopolysaccharide-(LPS)-induced	NNP
cord-015021-pol2qm74	7701	38	shock	shock	NN
cord-015021-pol2qm74	7701	39	with	with	IN
cord-015021-pol2qm74	7701	40	disseminated	disseminate	VBN
cord-015021-pol2qm74	7701	41	intravascular	intravascular	JJ
cord-015021-pol2qm74	7701	42	coagulation	coagulation	NN
cord-015021-pol2qm74	7701	43	has	have	VBZ
cord-015021-pol2qm74	7701	44	shown	show	VBN
cord-015021-pol2qm74	7701	45	that	that	IN
cord-015021-pol2qm74	7701	46	prelreatment	prelreatment	JJ
cord-015021-pol2qm74	7701	47	with	with	IN
cord-015021-pol2qm74	7701	48	recombinant	recombinant	JJ
cord-015021-pol2qm74	7701	49	desulfatohirudin	desulfatohirudin	NNP
cord-015021-pol2qm74	7702	1	(	(	-LRB-
cord-015021-pol2qm74	7702	2	r	r	NN
cord-015021-pol2qm74	7702	3	-	-	HYPH
cord-015021-pol2qm74	7702	4	H	H	NNP
cord-015021-pol2qm74	7702	5	)	)	-RRB-
cord-015021-pol2qm74	7702	6	or	or	CC
cord-015021-pol2qm74	7703	1	with	with	IN
cord-015021-pol2qm74	7703	2	a	a	DT
cord-015021-pol2qm74	7703	3	preformed	preformed	JJ
cord-015021-pol2qm74	7703	4	complex	complex	NN
cord-015021-pol2qm74	7703	5	of	of	IN
cord-015021-pol2qm74	7703	6	human	human	JJ
cord-015021-pol2qm74	7703	7	donor	donor	NN
cord-015021-pol2qm74	7703	8	antithrombin	antithrombin	NN
cord-015021-pol2qm74	7703	9	III	III	NNP
cord-015021-pol2qm74	7703	10	with	with	IN
cord-015021-pol2qm74	7703	11	heparin	heparin	NN
cord-015021-pol2qm74	7703	12	or	or	CC
cord-015021-pol2qm74	7703	13	post	post	NN
cord-015021-pol2qm74	7703	14	treatment	treatment	NN
cord-015021-pol2qm74	7703	15	with	with	IN
cord-015021-pol2qm74	7703	16	r	r	NN
cord-015021-pol2qm74	7703	17	-	-	HYPH
cord-015021-pol2qm74	7703	18	H	h	NN
cord-015021-pol2qm74	7703	19	are	be	VBP
cord-015021-pol2qm74	7703	20	able	able	JJ
cord-015021-pol2qm74	7703	21	to	to	TO
cord-015021-pol2qm74	7703	22	block	block	VB
cord-015021-pol2qm74	7703	23	the	the	DT
cord-015021-pol2qm74	7703	24	degradation	degradation	NN
cord-015021-pol2qm74	7703	25	of	of	IN
cord-015021-pol2qm74	7703	26	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	7703	27	and	and	CC
cord-015021-pol2qm74	7703	28	the	the	DT
cord-015021-pol2qm74	7703	29	formation	formation	NN
cord-015021-pol2qm74	7703	30	of	of	IN
cord-015021-pol2qm74	7703	31	fibrin	fibrin	NN
cord-015021-pol2qm74	7703	32	monomer	monomer	NN
cord-015021-pol2qm74	7703	33	.	.	.
cord-015021-pol2qm74	7704	1	In	in	IN
cord-015021-pol2qm74	7704	2	addition	addition	NN
cord-015021-pol2qm74	7704	3	,	,	,
cord-015021-pol2qm74	7704	4	after	after	IN
cord-015021-pol2qm74	7704	5	pretreatment	pretreatment	NN
cord-015021-pol2qm74	7704	6	with	with	IN
cord-015021-pol2qm74	7704	7	r	r	NN
cord-015021-pol2qm74	7704	8	-	-	HYPH
cord-015021-pol2qm74	7704	9	H	h	NN
cord-015021-pol2qm74	7704	10	it	-PRON-	PRP
cord-015021-pol2qm74	7704	11	was	be	VBD
cord-015021-pol2qm74	7704	12	found	find	VBN
cord-015021-pol2qm74	7704	13	that	that	IN
cord-015021-pol2qm74	7704	14	LPS	LPS	NNP
cord-015021-pol2qm74	7704	15	-	-	HYPH
cord-015021-pol2qm74	7704	16	induced	induce	VBN
cord-015021-pol2qm74	7704	17	lung	lung	NN
cord-015021-pol2qm74	7704	18	injury	injury	NN
cord-015021-pol2qm74	7704	19	was	be	VBD
cord-015021-pol2qm74	7704	20	reduced	reduce	VBN
cord-015021-pol2qm74	7704	21	.	.	.
cord-015021-pol2qm74	7705	1	Since	since	IN
cord-015021-pol2qm74	7705	2	both	both	DT
cord-015021-pol2qm74	7705	3	natural	natural	JJ
cord-015021-pol2qm74	7705	4	hirudin	hirudin	NN
cord-015021-pol2qm74	7705	5	as	as	RB
cord-015021-pol2qm74	7705	6	well	well	RB
cord-015021-pol2qm74	7705	7	as	as	IN
cord-015021-pol2qm74	7705	8	r	r	NN
cord-015021-pol2qm74	7705	9	-	-	HYPH
cord-015021-pol2qm74	7705	10	H	h	NN
cord-015021-pol2qm74	7705	11	were	be	VBD
cord-015021-pol2qm74	7705	12	well	well	RB
cord-015021-pol2qm74	7705	13	tolerated	tolerate	VBN
cord-015021-pol2qm74	7705	14	by	by	IN
cord-015021-pol2qm74	7705	15	healthy	healthy	JJ
cord-015021-pol2qm74	7705	16	volunteers	volunteer	NNS
cord-015021-pol2qm74	7705	17	,	,	,
cord-015021-pol2qm74	7705	18	adminislration	adminislration	NN
cord-015021-pol2qm74	7705	19	of	of	IN
cord-015021-pol2qm74	7705	20	r	r	NN
cord-015021-pol2qm74	7705	21	-	-	HYPH
cord-015021-pol2qm74	7705	22	H	h	NN
cord-015021-pol2qm74	7705	23	may	may	MD
cord-015021-pol2qm74	7705	24	be	be	VB
cord-015021-pol2qm74	7705	25	a	a	DT
cord-015021-pol2qm74	7705	26	promising	promising	JJ
cord-015021-pol2qm74	7705	27	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7705	28	approach	approach	NN
cord-015021-pol2qm74	7705	29	in	in	IN
cord-015021-pol2qm74	7705	30	patients	patient	NNS
cord-015021-pol2qm74	7705	31	with	with	IN
cord-015021-pol2qm74	7705	32	sepsis	sepsis	NN
cord-015021-pol2qm74	7705	33	and	and	CC
cord-015021-pol2qm74	7705	34	SIRS	sirs	NN
cord-015021-pol2qm74	7705	35	.	.	.
cord-015021-pol2qm74	7706	1	Corticosteroids	corticosteroid	NNS
cord-015021-pol2qm74	7706	2	have	have	VBP
cord-015021-pol2qm74	7706	3	been	be	VBN
cord-015021-pol2qm74	7706	4	used	use	VBN
cord-015021-pol2qm74	7706	5	in	in	IN
cord-015021-pol2qm74	7706	6	the	the	DT
cord-015021-pol2qm74	7706	7	management	management	NN
cord-015021-pol2qm74	7706	8	of	of	IN
cord-015021-pol2qm74	7706	9	various	various	JJ
cord-015021-pol2qm74	7706	10	shock	shock	NN
cord-015021-pol2qm74	7706	11	syndroms	syndrom	NNS
cord-015021-pol2qm74	7706	12	including	include	VBG
cord-015021-pol2qm74	7706	13	sepsis	sepsis	NN
cord-015021-pol2qm74	7706	14	.	.	.
cord-015021-pol2qm74	7707	1	The	the	DT
cord-015021-pol2qm74	7707	2	data	datum	NNS
cord-015021-pol2qm74	7707	3	concerning	concern	VBG
cord-015021-pol2qm74	7707	4	the	the	DT
cord-015021-pol2qm74	7707	5	effects	effect	NNS
cord-015021-pol2qm74	7707	6	of	of	IN
cord-015021-pol2qm74	7707	7	this	this	DT
cord-015021-pol2qm74	7707	8	therapy	therapy	NN
cord-015021-pol2qm74	7707	9	is	be	VBZ
cord-015021-pol2qm74	7707	10	,	,	,
cord-015021-pol2qm74	7707	11	however	however	RB
cord-015021-pol2qm74	7707	12	,	,	,
cord-015021-pol2qm74	7707	13	conflicting	conflict	VBG
cord-015021-pol2qm74	7707	14	and	and	CC
cord-015021-pol2qm74	7707	15	in	in	IN
cord-015021-pol2qm74	7707	16	large	large	JJ
cord-015021-pol2qm74	7707	17	prospective	prospective	JJ
cord-015021-pol2qm74	7707	18	studies	study	NNS
cord-015021-pol2qm74	7707	19	,	,	,
cord-015021-pol2qm74	7707	20	the	the	DT
cord-015021-pol2qm74	7707	21	use	use	NN
cord-015021-pol2qm74	7707	22	of	of	IN
cord-015021-pol2qm74	7707	23	early	early	JJ
cord-015021-pol2qm74	7707	24	administration	administration	NN
cord-015021-pol2qm74	7707	25	of	of	IN
cord-015021-pol2qm74	7707	26	high	high	JJ
cord-015021-pol2qm74	7707	27	doses	dose	NNS
cord-015021-pol2qm74	7707	28	of	of	IN
cord-015021-pol2qm74	7707	29	corticosteroids	corticosteroid	NNS
cord-015021-pol2qm74	7707	30	have	have	VBP
cord-015021-pol2qm74	7707	31	been	be	VBN
cord-015021-pol2qm74	7707	32	found	find	VBN
cord-015021-pol2qm74	7707	33	to	to	TO
cord-015021-pol2qm74	7707	34	give	give	VB
cord-015021-pol2qm74	7707	35	no	no	DT
cord-015021-pol2qm74	7707	36	beneficial	beneficial	JJ
cord-015021-pol2qm74	7707	37	effects	effect	NNS
cord-015021-pol2qm74	7707	38	in	in	IN
cord-015021-pol2qm74	7707	39	patients	patient	NNS
cord-015021-pol2qm74	7707	40	with	with	IN
cord-015021-pol2qm74	7707	41	sepsis	sepsis	NN
cord-015021-pol2qm74	7707	42	.	.	.
cord-015021-pol2qm74	7708	1	We	-PRON-	PRP
cord-015021-pol2qm74	7708	2	have	have	VBP
cord-015021-pol2qm74	7708	3	particularly	particularly	RB
cord-015021-pol2qm74	7708	4	been	be	VBN
cord-015021-pol2qm74	7708	5	engaged	engage	VBN
cord-015021-pol2qm74	7708	6	in	in	IN
cord-015021-pol2qm74	7708	7	studies	study	NNS
cord-015021-pol2qm74	7708	8	on	on	IN
cord-015021-pol2qm74	7708	9	possible	possible	JJ
cord-015021-pol2qm74	7708	10	effects	effect	NNS
cord-015021-pol2qm74	7708	11	of	of	IN
cord-015021-pol2qm74	7708	12	corticosteroids	corticosteroid	NNS
cord-015021-pol2qm74	7708	13	on	on	IN
cord-015021-pol2qm74	7708	14	the	the	DT
cord-015021-pol2qm74	7708	15	plasma	plasma	NN
cord-015021-pol2qm74	7708	16	cascade	cascade	NN
cord-015021-pol2qm74	7708	17	systems	system	NNS
cord-015021-pol2qm74	7708	18	and	and	CC
cord-015021-pol2qm74	7708	19	on	on	IN
cord-015021-pol2qm74	7708	20	the	the	DT
cord-015021-pol2qm74	7708	21	mediator	mediator	NN
cord-015021-pol2qm74	7708	22	release	release	NN
cord-015021-pol2qm74	7708	23	from	from	IN
cord-015021-pol2qm74	7708	24	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7708	25	.	.	.
cord-015021-pol2qm74	7709	1	In	in	IN
cord-015021-pol2qm74	7709	2	in	in	FW
cord-015021-pol2qm74	7709	3	vitro	vitro	FW
cord-015021-pol2qm74	7709	4	studies	study	NNS
cord-015021-pol2qm74	7709	5	,	,	,
cord-015021-pol2qm74	7709	6	high	high	JJ
cord-015021-pol2qm74	7709	7	doses	dose	NNS
cord-015021-pol2qm74	7709	8	of	of	IN
cord-015021-pol2qm74	7709	9	methylprednisolone	methylprednisolone	NNP
cord-015021-pol2qm74	7709	10	were	be	VBD
cord-015021-pol2qm74	7709	11	found	find	VBN
cord-015021-pol2qm74	7709	12	to	to	TO
cord-015021-pol2qm74	7709	13	facilitate	facilitate	VB
cord-015021-pol2qm74	7709	14	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7709	15	induced	induce	VBN
cord-015021-pol2qm74	7709	16	generation	generation	NN
cord-015021-pol2qm74	7709	17	of	of	IN
cord-015021-pol2qm74	7709	18	plasma	plasma	NN
cord-015021-pol2qm74	7709	19	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	7709	20	.	.	.
cord-015021-pol2qm74	7710	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	7710	2	,	,	,
cord-015021-pol2qm74	7710	3	plasma	plasma	NN
cord-015021-pol2qm74	7710	4	prekallikrein	prekallikrein	NNP
cord-015021-pol2qm74	7710	5	and	and	CC
cord-015021-pol2qm74	7710	6	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	7710	7	inhibitor	inhibitor	NN
cord-015021-pol2qm74	7710	8	values	value	NNS
cord-015021-pol2qm74	7710	9	decreased	decrease	VBD
cord-015021-pol2qm74	7710	10	together	together	RB
cord-015021-pol2qm74	7710	11	with	with	IN
cord-015021-pol2qm74	7710	12	formation	formation	NN
cord-015021-pol2qm74	7710	13	of	of	IN
cord-015021-pol2qm74	7710	14	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	7710	15	-	-	HYPH
cord-015021-pol2qm74	7710	16	C1	C1	NNP
cord-015021-pol2qm74	7710	17	inhibitor	inhibitor	NN
cord-015021-pol2qm74	7710	18	complexes	complex	NNS
cord-015021-pol2qm74	7710	19	(	(	-LRB-
cord-015021-pol2qm74	7710	20	1	1	CD
cord-015021-pol2qm74	7710	21	)	)	-RRB-
cord-015021-pol2qm74	7710	22	.	.	.
cord-015021-pol2qm74	7711	1	In	in	IN
cord-015021-pol2qm74	7711	2	this	this	DT
cord-015021-pol2qm74	7711	3	in	in	FW
cord-015021-pol2qm74	7711	4	vitro	vitro	FW
cord-015021-pol2qm74	7711	5	plasma	plasma	NN
cord-015021-pol2qm74	7711	6	model	model	NN
cord-015021-pol2qm74	7711	7	we	-PRON-	PRP
cord-015021-pol2qm74	7711	8	also	also	RB
cord-015021-pol2qm74	7711	9	found	find	VBD
cord-015021-pol2qm74	7711	10	that	that	IN
cord-015021-pol2qm74	7711	11	methylpredoisolone	methylpredoisolone	NN
cord-015021-pol2qm74	7711	12	alone	alone	RB
cord-015021-pol2qm74	7711	13	in	in	IN
cord-015021-pol2qm74	7711	14	doses	dose	NNS
cord-015021-pol2qm74	7711	15	of	of	IN
cord-015021-pol2qm74	7711	16	1	1	CD
cord-015021-pol2qm74	7711	17	mg	mg	NNP
cord-015021-pol2qm74	7711	18	/	/	SYM
cord-015021-pol2qm74	7711	19	ml	ml	NN
cord-015021-pol2qm74	7711	20	induced	induce	VBD
cord-015021-pol2qm74	7711	21	contact	contact	NN
cord-015021-pol2qm74	7711	22	activation	activation	NN
cord-015021-pol2qm74	7711	23	with	with	IN
cord-015021-pol2qm74	7711	24	the	the	DT
cord-015021-pol2qm74	7711	25	formation	formation	NN
cord-015021-pol2qm74	7711	26	of	of	IN
cord-015021-pol2qm74	7711	27	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	7711	28	-	-	HYPH
cord-015021-pol2qm74	7711	29	C1	C1	NNP
cord-015021-pol2qm74	7711	30	inhibitor	inhibitor	NN
cord-015021-pol2qm74	7711	31	complexes	complex	NNS
cord-015021-pol2qm74	7711	32	.	.	.
cord-015021-pol2qm74	7712	1	Methylprednisolone	Methylprednisolone	NNP
cord-015021-pol2qm74	7712	2	was	be	VBD
cord-015021-pol2qm74	7712	3	also	also	RB
cord-015021-pol2qm74	7712	4	found	find	VBN
cord-015021-pol2qm74	7712	5	to	to	TO
cord-015021-pol2qm74	7712	6	have	have	VB
cord-015021-pol2qm74	7712	7	an	an	DT
cord-015021-pol2qm74	7712	8	additive	additive	NN
cord-015021-pol2qm74	7712	9	effect	effect	NN
cord-015021-pol2qm74	7712	10	on	on	IN
cord-015021-pol2qm74	7712	11	endotoxine	endotoxine	NN
cord-015021-pol2qm74	7712	12	induced	induce	VBN
cord-015021-pol2qm74	7712	13	decreases	decrease	VBZ
cord-015021-pol2qm74	7712	14	in	in	IN
cord-015021-pol2qm74	7712	15	kallikrein	kallikrein	NNP
cord-015021-pol2qm74	7712	16	inhibitor	inhibitor	NN
cord-015021-pol2qm74	7712	17	functions	function	NNS
cord-015021-pol2qm74	7712	18	.	.	.
cord-015021-pol2qm74	7713	1	In	in	IN
cord-015021-pol2qm74	7713	2	the	the	DT
cord-015021-pol2qm74	7713	3	same	same	JJ
cord-015021-pol2qm74	7713	4	experimental	experimental	JJ
cord-015021-pol2qm74	7713	5	model	model	NN
cord-015021-pol2qm74	7713	6	on	on	IN
cord-015021-pol2qm74	7713	7	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7713	8	methylprednisoione	methylprednisoione	NN
cord-015021-pol2qm74	7713	9	was	be	VBD
cord-015021-pol2qm74	7713	10	found	find	VBN
cord-015021-pol2qm74	7713	11	to	to	TO
cord-015021-pol2qm74	7713	12	give	give	VB
cord-015021-pol2qm74	7713	13	an	an	DT
cord-015021-pol2qm74	7713	14	additive	additive	NN
cord-015021-pol2qm74	7713	15	effect	effect	NN
cord-015021-pol2qm74	7713	16	on	on	IN
cord-015021-pol2qm74	7713	17	activation	activation	NN
cord-015021-pol2qm74	7713	18	of	of	IN
cord-015021-pol2qm74	7713	19	the	the	DT
cord-015021-pol2qm74	7713	20	initial	initial	JJ
cord-015021-pol2qm74	7713	21	part	part	NN
cord-015021-pol2qm74	7713	22	of	of	IN
cord-015021-pol2qm74	7713	23	the	the	DT
cord-015021-pol2qm74	7713	24	complement	complement	NN
cord-015021-pol2qm74	7713	25	cascade	cascade	NN
cord-015021-pol2qm74	7713	26	(	(	-LRB-
cord-015021-pol2qm74	7713	27	2	2	CD
cord-015021-pol2qm74	7713	28	)	)	-RRB-
cord-015021-pol2qm74	7713	29	.	.	.
cord-015021-pol2qm74	7714	1	Activation	activation	NN
cord-015021-pol2qm74	7714	2	of	of	IN
cord-015021-pol2qm74	7714	3	the	the	DT
cord-015021-pol2qm74	7714	4	terminal	terminal	JJ
cord-015021-pol2qm74	7714	5	part	part	NN
cord-015021-pol2qm74	7714	6	of	of	IN
cord-015021-pol2qm74	7714	7	complement	complement	NN
cord-015021-pol2qm74	7714	8	,	,	,
cord-015021-pol2qm74	7714	9	however	however	RB
cord-015021-pol2qm74	7714	10	,	,	,
cord-015021-pol2qm74	7714	11	was	be	VBD
cord-015021-pol2qm74	7714	12	inhibited	inhibit	VBN
cord-015021-pol2qm74	7714	13	by	by	IN
cord-015021-pol2qm74	7714	14	the	the	DT
cord-015021-pol2qm74	7714	15	same	same	JJ
cord-015021-pol2qm74	7714	16	dose	dose	NN
cord-015021-pol2qm74	7714	17	of	of	IN
cord-015021-pol2qm74	7714	18	methylprednisolone	methylprednisolone	NN
cord-015021-pol2qm74	7714	19	.	.	.
cord-015021-pol2qm74	7715	1	Addition	addition	NN
cord-015021-pol2qm74	7715	2	of	of	IN
cord-015021-pol2qm74	7715	3	methylprednisolone	methylprednisolone	NN
cord-015021-pol2qm74	7715	4	alone	alone	JJ
cord-015021-pol2qm74	7715	5	to	to	IN
cord-015021-pol2qm74	7715	6	plasma	plasma	NN
cord-015021-pol2qm74	7715	7	was	be	VBD
cord-015021-pol2qm74	7715	8	also	also	RB
cord-015021-pol2qm74	7715	9	found	find	VBN
cord-015021-pol2qm74	7715	10	to	to	TO
cord-015021-pol2qm74	7715	11	activate	activate	VB
cord-015021-pol2qm74	7715	12	the	the	DT
cord-015021-pol2qm74	7715	13	initial	initial	JJ
cord-015021-pol2qm74	7715	14	part	part	NN
cord-015021-pol2qm74	7715	15	of	of	IN
cord-015021-pol2qm74	7715	16	complement	complement	NN
cord-015021-pol2qm74	7715	17	.	.	.
cord-015021-pol2qm74	7716	1	Using	use	VBG
cord-015021-pol2qm74	7716	2	a	a	DT
cord-015021-pol2qm74	7716	3	full	full	JJ
cord-015021-pol2qm74	7716	4	blood	blood	NN
cord-015021-pol2qm74	7716	5	model	model	NN
cord-015021-pol2qm74	7716	6	,	,	,
cord-015021-pol2qm74	7716	7	we	-PRON-	PRP
cord-015021-pol2qm74	7716	8	studied	study	VBD
cord-015021-pol2qm74	7716	9	the	the	DT
cord-015021-pol2qm74	7716	10	effect	effect	NN
cord-015021-pol2qm74	7716	11	of	of	IN
cord-015021-pol2qm74	7716	12	methylpredoisolone	methylpredoisolone	NN
cord-015021-pol2qm74	7716	13	in	in	IN
cord-015021-pol2qm74	7716	14	modulating	modulate	VBG
cord-015021-pol2qm74	7716	15	the	the	DT
cord-015021-pol2qm74	7716	16	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7716	17	induced	induce	VBN
cord-015021-pol2qm74	7716	18	cytokine	cytokine	NN
cord-015021-pol2qm74	7716	19	response	response	NN
cord-015021-pol2qm74	7716	20	.	.	.
cord-015021-pol2qm74	7717	1	When	when	WRB
cord-015021-pol2qm74	7717	2	103	103	CD
cord-015021-pol2qm74	7717	3	ng	ng	NNP
cord-015021-pol2qm74	7717	4	/	/	SYM
cord-015021-pol2qm74	7717	5	l	l	NNP
cord-015021-pol2qm74	7717	6	E.	E.	NNP
cord-015021-pol2qm74	7717	7	coli	coli	NNS
cord-015021-pol2qm74	7717	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7717	9	was	be	VBD
cord-015021-pol2qm74	7717	10	added	add	VBN
cord-015021-pol2qm74	7717	11	to	to	IN
cord-015021-pol2qm74	7717	12	citrated	citrate	VBN
cord-015021-pol2qm74	7717	13	blood	blood	NN
cord-015021-pol2qm74	7717	14	from	from	IN
cord-015021-pol2qm74	7717	15	healthy	healthy	JJ
cord-015021-pol2qm74	7717	16	human	human	JJ
cord-015021-pol2qm74	7717	17	donors	donor	NNS
cord-015021-pol2qm74	7717	18	preinkubation	preinkubation	NN
cord-015021-pol2qm74	7717	19	with	with	IN
cord-015021-pol2qm74	7718	1	20	20	CD
cord-015021-pol2qm74	7718	2	gg	gg	NNP
cord-015021-pol2qm74	7718	3	/	/	SYM
cord-015021-pol2qm74	7718	4	ml	ml	NN
cord-015021-pol2qm74	7718	5	methylprednisolone	methylprednisolone	NN
cord-015021-pol2qm74	7718	6	significantly	significantly	RB
cord-015021-pol2qm74	7718	7	reduced	reduce	VBD
cord-015021-pol2qm74	7718	8	the	the	DT
cord-015021-pol2qm74	7718	9	release	release	NN
cord-015021-pol2qm74	7718	10	of	of	IN
cord-015021-pol2qm74	7718	11	tumor	tumor	NN
cord-015021-pol2qm74	7718	12	necrosis	necrosis	NN
cord-015021-pol2qm74	7718	13	factor	factor	NN
cord-015021-pol2qm74	7718	14	et	et	NNP
cord-015021-pol2qm74	7718	15	(	(	-LRB-
cord-015021-pol2qm74	7718	16	79	79	CD
cord-015021-pol2qm74	7718	17	%	%	NN
cord-015021-pol2qm74	7718	18	)	)	-RRB-
cord-015021-pol2qm74	7718	19	and	and	CC
cord-015021-pol2qm74	7718	20	interleukin-6	interleukin-6	NNP
cord-015021-pol2qm74	7718	21	(	(	-LRB-
cord-015021-pol2qm74	7718	22	63	63	CD
cord-015021-pol2qm74	7718	23	%	%	NN
cord-015021-pol2qm74	7718	24	)	)	-RRB-
cord-015021-pol2qm74	7718	25	at	at	IN
cord-015021-pol2qm74	7718	26	two	two	CD
cord-015021-pol2qm74	7718	27	hours	hour	NNS
cord-015021-pol2qm74	7718	28	after	after	IN
cord-015021-pol2qm74	7718	29	exposure	exposure	NN
cord-015021-pol2qm74	7718	30	to	to	IN
cord-015021-pol2qm74	7718	31	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7718	32	.	.	.
cord-015021-pol2qm74	7719	1	In	in	IN
cord-015021-pol2qm74	7719	2	conclusion	conclusion	NN
cord-015021-pol2qm74	7719	3	,	,	,
cord-015021-pol2qm74	7719	4	these	these	DT
cord-015021-pol2qm74	7719	5	studies	study	NNS
cord-015021-pol2qm74	7719	6	show	show	VBP
cord-015021-pol2qm74	7719	7	that	that	IN
cord-015021-pol2qm74	7719	8	corticosteroids	corticosteroid	NNS
cord-015021-pol2qm74	7719	9	might	may	MD
cord-015021-pol2qm74	7719	10	facilitate	facilitate	VB
cord-015021-pol2qm74	7719	11	contact	contact	NN
cord-015021-pol2qm74	7719	12	activation	activation	NN
cord-015021-pol2qm74	7719	13	of	of	IN
cord-015021-pol2qm74	7719	14	plasma	plasma	NN
cord-015021-pol2qm74	7719	15	and	and	CC
cord-015021-pol2qm74	7719	16	reduce	reduce	VB
cord-015021-pol2qm74	7719	17	the	the	DT
cord-015021-pol2qm74	7719	18	function	function	NN
cord-015021-pol2qm74	7719	19	of	of	IN
cord-015021-pol2qm74	7719	20	major	major	JJ
cord-015021-pol2qm74	7719	21	protease	protease	NN
cord-015021-pol2qm74	7719	22	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	7719	23	.	.	.
cord-015021-pol2qm74	7720	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	7720	2	,	,	,
cord-015021-pol2qm74	7720	3	we	-PRON-	PRP
cord-015021-pol2qm74	7720	4	also	also	RB
cord-015021-pol2qm74	7720	5	observed	observe	VBD
cord-015021-pol2qm74	7720	6	that	that	IN
cord-015021-pol2qm74	7720	7	this	this	DT
cord-015021-pol2qm74	7720	8	drag	drag	NN
cord-015021-pol2qm74	7720	9	in	in	RP
cord-015021-pol2qm74	7720	10	in	in	IN
cord-015021-pol2qm74	7720	11	vitro	vitro	FW
cord-015021-pol2qm74	7720	12	conditions	condition	NNS
cord-015021-pol2qm74	7720	13	facilitated	facilitate	VBD
cord-015021-pol2qm74	7720	14	activation	activation	NN
cord-015021-pol2qm74	7720	15	of	of	IN
cord-015021-pol2qm74	7720	16	complement	complement	NN
cord-015021-pol2qm74	7720	17	.	.	.
cord-015021-pol2qm74	7721	1	On	on	IN
cord-015021-pol2qm74	7721	2	the	the	DT
cord-015021-pol2qm74	7721	3	other	other	JJ
cord-015021-pol2qm74	7721	4	hand	hand	NN
cord-015021-pol2qm74	7721	5	,	,	,
cord-015021-pol2qm74	7721	6	corticosteroids	corticosteroid	NNS
cord-015021-pol2qm74	7721	7	were	be	VBD
cord-015021-pol2qm74	7721	8	found	find	VBN
cord-015021-pol2qm74	7721	9	to	to	TO
cord-015021-pol2qm74	7721	10	reduce	reduce	VB
cord-015021-pol2qm74	7721	11	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7721	12	induced	induce	VBN
cord-015021-pol2qm74	7721	13	cytokine	cytokine	NN
cord-015021-pol2qm74	7721	14	release	release	NN
cord-015021-pol2qm74	7721	15	from	from	IN
cord-015021-pol2qm74	7721	16	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7721	17	in	in	IN
cord-015021-pol2qm74	7721	18	whole	whole	JJ
cord-015021-pol2qm74	7721	19	blood	blood	NN
cord-015021-pol2qm74	7721	20	.	.	.
cord-015021-pol2qm74	7722	1	These	these	DT
cord-015021-pol2qm74	7722	2	studies	study	NNS
cord-015021-pol2qm74	7722	3	also	also	RB
cord-015021-pol2qm74	7722	4	showed	show	VBD
cord-015021-pol2qm74	7722	5	a	a	DT
cord-015021-pol2qm74	7722	6	dose	dose	JJ
cord-015021-pol2qm74	7722	7	dependence	dependence	NN
cord-015021-pol2qm74	7722	8	of	of	IN
cord-015021-pol2qm74	7722	9	the	the	DT
cord-015021-pol2qm74	7722	10	effects	effect	NNS
cord-015021-pol2qm74	7722	11	of	of	IN
cord-015021-pol2qm74	7722	12	corticosteroids	corticosteroid	NNS
cord-015021-pol2qm74	7722	13	on	on	IN
cord-015021-pol2qm74	7722	14	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7722	15	induced	induce	VBN
cord-015021-pol2qm74	7722	16	cellular	cellular	JJ
cord-015021-pol2qm74	7722	17	and	and	CC
cord-015021-pol2qm74	7722	18	cascade	cascade	NN
cord-015021-pol2qm74	7722	19	system	system	NN
cord-015021-pol2qm74	7722	20	activation	activation	NN
cord-015021-pol2qm74	7722	21	.	.	.
cord-015021-pol2qm74	7723	1	Different	different	JJ
cord-015021-pol2qm74	7723	2	predisposing	predisposing	JJ
cord-015021-pol2qm74	7723	3	conditions	condition	NNS
cord-015021-pol2qm74	7723	4	like	like	IN
cord-015021-pol2qm74	7723	5	extensive	extensive	JJ
cord-015021-pol2qm74	7723	6	trauma	trauma	NN
cord-015021-pol2qm74	7723	7	,	,	,
cord-015021-pol2qm74	7723	8	infection	infection	NN
cord-015021-pol2qm74	7723	9	or	or	CC
cord-015021-pol2qm74	7723	10	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	7723	11	result	result	NN
cord-015021-pol2qm74	7723	12	in	in	IN
cord-015021-pol2qm74	7723	13	a	a	DT
cord-015021-pol2qm74	7723	14	remarkably	remarkably	RB
cord-015021-pol2qm74	7723	15	similar	similar	JJ
cord-015021-pol2qm74	7723	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7723	17	response	response	NN
cord-015021-pol2qm74	7723	18	.	.	.
cord-015021-pol2qm74	7724	1	Although	although	IN
cord-015021-pol2qm74	7724	2	thls	thls	NNP
cord-015021-pol2qm74	7724	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7724	4	response	response	NN
cord-015021-pol2qm74	7724	5	primarily	primarily	RB
cord-015021-pol2qm74	7724	6	aims	aim	VBZ
cord-015021-pol2qm74	7724	7	at	at	IN
cord-015021-pol2qm74	7724	8	the	the	DT
cord-015021-pol2qm74	7724	9	removal	removal	NN
cord-015021-pol2qm74	7724	10	of	of	IN
cord-015021-pol2qm74	7724	11	devitalized	devitalized	JJ
cord-015021-pol2qm74	7724	12	tissues	tissue	NNS
cord-015021-pol2qm74	7724	13	,	,	,
cord-015021-pol2qm74	7724	14	destruction	destruction	NN
cord-015021-pol2qm74	7724	15	of	of	IN
cord-015021-pol2qm74	7724	16	bacteria	bacteria	NNS
cord-015021-pol2qm74	7724	17	and	and	CC
cord-015021-pol2qm74	7724	18	reestablishment	reestablishment	NN
cord-015021-pol2qm74	7724	19	of	of	IN
cord-015021-pol2qm74	7724	20	the	the	DT
cord-015021-pol2qm74	7724	21	integrity	integrity	NN
cord-015021-pol2qm74	7724	22	of	of	IN
cord-015021-pol2qm74	7724	23	host	host	NN
cord-015021-pol2qm74	7724	24	tissues	tissue	NNS
cord-015021-pol2qm74	7724	25	,	,	,
cord-015021-pol2qm74	7724	26	it	-PRON-	PRP
cord-015021-pol2qm74	7724	27	may	may	MD
cord-015021-pol2qm74	7724	28	potentially	potentially	RB
cord-015021-pol2qm74	7724	29	become	become	VB
cord-015021-pol2qm74	7724	30	unregulated	unregulated	JJ
cord-015021-pol2qm74	7724	31	and	and	CC
cord-015021-pol2qm74	7724	32	generalized	generalized	JJ
cord-015021-pol2qm74	7724	33	and	and	CC
cord-015021-pol2qm74	7724	34	thereby	thereby	RB
cord-015021-pol2qm74	7724	35	producing	produce	VBG
cord-015021-pol2qm74	7724	36	deleterious	deleterious	JJ
cord-015021-pol2qm74	7724	37	effects	effect	NNS
cord-015021-pol2qm74	7724	38	to	to	IN
cord-015021-pol2qm74	7724	39	vital	vital	JJ
cord-015021-pol2qm74	7724	40	organs	organ	NNS
cord-015021-pol2qm74	7724	41	or	or	CC
cord-015021-pol2qm74	7724	42	the	the	DT
cord-015021-pol2qm74	7724	43	body	body	NN
cord-015021-pol2qm74	7724	44	"	"	''
cord-015021-pol2qm74	7724	45	as	as	IN
cord-015021-pol2qm74	7724	46	a	a	DT
cord-015021-pol2qm74	7724	47	whole	whole	NN
cord-015021-pol2qm74	7724	48	.	.	.
cord-015021-pol2qm74	7725	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	7725	2	play	play	VBP
cord-015021-pol2qm74	7725	3	an	an	DT
cord-015021-pol2qm74	7725	4	important	important	JJ
cord-015021-pol2qm74	7725	5	role	role	NN
cord-015021-pol2qm74	7725	6	in	in	IN
cord-015021-pol2qm74	7725	7	the	the	DT
cord-015021-pol2qm74	7725	8	development	development	NN
cord-015021-pol2qm74	7725	9	of	of	IN
cord-015021-pol2qm74	7725	10	the	the	DT
cord-015021-pol2qm74	7725	11	systemic	systemic	JJ
cord-015021-pol2qm74	7725	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7725	13	response	response	NN
cord-015021-pol2qm74	7725	14	.	.	.
cord-015021-pol2qm74	7726	1	Most	Most	JJS
cord-015021-pol2qm74	7726	2	of	of	IN
cord-015021-pol2qm74	7726	3	their	-PRON-	PRP$
cord-015021-pol2qm74	7726	4	biological	biological	JJ
cord-015021-pol2qm74	7726	5	effects	effect	NNS
cord-015021-pol2qm74	7726	6	,	,	,
cord-015021-pol2qm74	7726	7	however	however	RB
cord-015021-pol2qm74	7726	8	,	,	,
cord-015021-pol2qm74	7726	9	are	be	VBP
cord-015021-pol2qm74	7726	10	not	not	RB
cord-015021-pol2qm74	7726	11	directly	directly	RB
cord-015021-pol2qm74	7726	12	mediated	mediate	VBN
cord-015021-pol2qm74	7726	13	but	but	CC
cord-015021-pol2qm74	7726	14	exerted	exert	VBN
cord-015021-pol2qm74	7726	15	through	through	IN
cord-015021-pol2qm74	7726	16	other	other	JJ
cord-015021-pol2qm74	7726	17	mediator	mediator	NN
cord-015021-pol2qm74	7726	18	systems	system	NNS
cord-015021-pol2qm74	7726	19	.	.	.
cord-015021-pol2qm74	7727	1	When	when	WRB
cord-015021-pol2qm74	7727	2	the	the	DT
cord-015021-pol2qm74	7727	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7727	4	response	response	NN
cord-015021-pol2qm74	7727	5	results	result	NNS
cord-015021-pol2qm74	7727	6	in	in	IN
cord-015021-pol2qm74	7727	7	the	the	DT
cord-015021-pol2qm74	7727	8	formation	formation	NN
cord-015021-pol2qm74	7727	9	of	of	IN
cord-015021-pol2qm74	7727	10	capillary	capillary	JJ
cord-015021-pol2qm74	7727	11	leak	leak	NN
cord-015021-pol2qm74	7727	12	syndrome	syndrome	NN
cord-015021-pol2qm74	7727	13	and	and	CC
cord-015021-pol2qm74	7727	14	refractory	refractory	JJ
cord-015021-pol2qm74	7727	15	hypotension	hypotension	NN
cord-015021-pol2qm74	7727	16	,	,	,
cord-015021-pol2qm74	7727	17	the	the	DT
cord-015021-pol2qm74	7727	18	unregulated	unregulated	JJ
cord-015021-pol2qm74	7727	19	activation	activation	NN
cord-015021-pol2qm74	7727	20	of	of	IN
cord-015021-pol2qm74	7727	21	complement	complement	NN
cord-015021-pol2qm74	7727	22	and	and	CC
cord-015021-pol2qm74	7727	23	contact	contact	NN
cord-015021-pol2qm74	7727	24	systems	system	NNS
cord-015021-pol2qm74	7727	25	appears	appear	VBZ
cord-015021-pol2qm74	7727	26	to	to	TO
cord-015021-pol2qm74	7727	27	be	be	VB
cord-015021-pol2qm74	7727	28	the	the	DT
cord-015021-pol2qm74	7727	29	cause	cause	NN
cord-015021-pol2qm74	7727	30	.	.	.
cord-015021-pol2qm74	7728	1	Both	both	DT
cord-015021-pol2qm74	7728	2	systems	system	NNS
cord-015021-pol2qm74	7728	3	are	be	VBP
cord-015021-pol2qm74	7728	4	almost	almost	RB
cord-015021-pol2qm74	7728	5	exclusively	exclusively	RB
cord-015021-pol2qm74	7728	6	regulated	regulate	VBN
cord-015021-pol2qm74	7728	7	by	by	IN
cord-015021-pol2qm74	7728	8	C1	C1	NNP
cord-015021-pol2qm74	7728	9	-	-	HYPH
cord-015021-pol2qm74	7728	10	1nhibitor	1nhibitor	CD
cord-015021-pol2qm74	7728	11	.	.	.
cord-015021-pol2qm74	7729	1	Am	be	VBP
cord-015021-pol2qm74	7729	2	unbalanced	unbalanced	JJ
cord-015021-pol2qm74	7729	3	degradation	degradation	NN
cord-015021-pol2qm74	7729	4	of	of	IN
cord-015021-pol2qm74	7729	5	the	the	DT
cord-015021-pol2qm74	7729	6	inhibitor	inhibitor	NN
cord-015021-pol2qm74	7729	7	protein	protein	NN
cord-015021-pol2qm74	7729	8	was	be	VBD
cord-015021-pol2qm74	7729	9	found	find	VBN
cord-015021-pol2qm74	7729	10	to	to	TO
cord-015021-pol2qm74	7729	11	be	be	VB
cord-015021-pol2qm74	7729	12	associated	associate	VBN
cord-015021-pol2qm74	7729	13	with	with	IN
cord-015021-pol2qm74	7729	14	the	the	DT
cord-015021-pol2qm74	7729	15	onset	onset	NN
cord-015021-pol2qm74	7729	16	of	of	IN
cord-015021-pol2qm74	7729	17	capillary	capillary	JJ
cord-015021-pol2qm74	7729	18	leakage	leakage	NN
cord-015021-pol2qm74	7729	19	in	in	IN
cord-015021-pol2qm74	7729	20	various	various	JJ
cord-015021-pol2qm74	7729	21	conditions	condition	NNS
cord-015021-pol2qm74	7729	22	such	such	JJ
cord-015021-pol2qm74	7729	23	as	as	IN
cord-015021-pol2qm74	7729	24	bone	bone	NN
cord-015021-pol2qm74	7729	25	marrow	marrow	NN
cord-015021-pol2qm74	7729	26	transplantation	transplantation	NN
cord-015021-pol2qm74	7729	27	,	,	,
cord-015021-pol2qm74	7729	28	severe	severe	JJ
cord-015021-pol2qm74	7729	29	burns	burn	NNS
cord-015021-pol2qm74	7729	30	,	,	,
cord-015021-pol2qm74	7729	31	and	and	CC
cord-015021-pol2qm74	7729	32	septic	septic	JJ
cord-015021-pol2qm74	7729	33	shock	shock	NN
cord-015021-pol2qm74	7729	34	.	.	.
cord-015021-pol2qm74	7730	1	These	these	DT
cord-015021-pol2qm74	7730	2	observations	observation	NNS
cord-015021-pol2qm74	7730	3	suggest	suggest	VBP
cord-015021-pol2qm74	7730	4	a	a	DT
cord-015021-pol2qm74	7730	5	relative	relative	JJ
cord-015021-pol2qm74	7730	6	deficiency	deficiency	NN
cord-015021-pol2qm74	7730	7	of	of	IN
cord-015021-pol2qm74	7730	8	biologically	biologically	RB
cord-015021-pol2qm74	7730	9	active	active	JJ
cord-015021-pol2qm74	7730	10	C3	c3	NN
cord-015021-pol2qm74	7730	11	-	-	HYPH
cord-015021-pol2qm74	7730	12	1nhibitor	1nhibitor	CD
cord-015021-pol2qm74	7730	13	in	in	IN
cord-015021-pol2qm74	7730	14	these	these	DT
cord-015021-pol2qm74	7730	15	septic	septic	JJ
cord-015021-pol2qm74	7730	16	shock	shock	NN
cord-015021-pol2qm74	7730	17	like	like	IN
cord-015021-pol2qm74	7730	18	syndromes	syndrome	NNS
cord-015021-pol2qm74	7730	19	.	.	.
cord-015021-pol2qm74	7731	1	Therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7731	2	intervention	intervention	NN
cord-015021-pol2qm74	7731	3	studies	study	NNS
cord-015021-pol2qm74	7731	4	were	be	VBD
cord-015021-pol2qm74	7731	5	initiated	initiate	VBN
cord-015021-pol2qm74	7731	6	using	use	VBG
cord-015021-pol2qm74	7731	7	high	high	JJ
cord-015021-pol2qm74	7731	8	doses	dose	NNS
cord-015021-pol2qm74	7731	9	of	of	IN
cord-015021-pol2qm74	7731	10	C1	C1	NNP
cord-015021-pol2qm74	7731	11	-	-	HYPH
cord-015021-pol2qm74	7731	12	1nhibitor	1nhibitor	CD
cord-015021-pol2qm74	7731	13	concentrate	concentrate	NN
cord-015021-pol2qm74	7731	14	.	.	.
cord-015021-pol2qm74	7732	1	First	first	JJ
cord-015021-pol2qm74	7732	2	results	result	NNS
cord-015021-pol2qm74	7732	3	are	be	VBP
cord-015021-pol2qm74	7732	4	promising	promising	JJ
cord-015021-pol2qm74	7732	5	,	,	,
cord-015021-pol2qm74	7732	6	as	as	IN
cord-015021-pol2qm74	7732	7	in	in	IN
cord-015021-pol2qm74	7732	8	most	most	JJS
cord-015021-pol2qm74	7732	9	patients	patient	NNS
cord-015021-pol2qm74	7732	10	the	the	DT
cord-015021-pol2qm74	7732	11	administration	administration	NN
cord-015021-pol2qm74	7732	12	of	of	IN
cord-015021-pol2qm74	7732	13	the	the	DT
cord-015021-pol2qm74	7732	14	drug	drug	NN
cord-015021-pol2qm74	7732	15	was	be	VBD
cord-015021-pol2qm74	7732	16	followed	follow	VBN
cord-015021-pol2qm74	7732	17	by	by	IN
cord-015021-pol2qm74	7732	18	a	a	DT
cord-015021-pol2qm74	7732	19	quick	quick	JJ
cord-015021-pol2qm74	7732	20	and	and	CC
cord-015021-pol2qm74	7732	21	marked	marked	JJ
cord-015021-pol2qm74	7732	22	improvement	improvement	NN
cord-015021-pol2qm74	7732	23	of	of	IN
cord-015021-pol2qm74	7732	24	the	the	DT
cord-015021-pol2qm74	7732	25	patient	patient	NN
cord-015021-pol2qm74	7732	26	's	's	POS
cord-015021-pol2qm74	7732	27	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	7732	28	.	.	.
cord-015021-pol2qm74	7733	1	Whether	whether	IN
cord-015021-pol2qm74	7733	2	the	the	DT
cord-015021-pol2qm74	7733	3	administration	administration	NN
cord-015021-pol2qm74	7733	4	of	of	IN
cord-015021-pol2qm74	7733	5	C1	C1	NNP
cord-015021-pol2qm74	7733	6	-	-	HYPH
cord-015021-pol2qm74	7733	7	1nhibitor	1nhibitor	CD
cord-015021-pol2qm74	7733	8	alone	alone	RB
cord-015021-pol2qm74	7733	9	or	or	CC
cord-015021-pol2qm74	7733	10	in	in	IN
cord-015021-pol2qm74	7733	11	combination	combination	NN
cord-015021-pol2qm74	7733	12	with	with	IN
cord-015021-pol2qm74	7733	13	other	other	JJ
cord-015021-pol2qm74	7733	14	drugs	drug	NNS
cord-015021-pol2qm74	7733	15	is	be	VBZ
cord-015021-pol2qm74	7733	16	also	also	RB
cord-015021-pol2qm74	7733	17	sufficient	sufficient	JJ
cord-015021-pol2qm74	7733	18	to	to	TO
cord-015021-pol2qm74	7733	19	improve	improve	VB
cord-015021-pol2qm74	7733	20	long	long	JJ
cord-015021-pol2qm74	7733	21	-	-	HYPH
cord-015021-pol2qm74	7733	22	time	time	NN
cord-015021-pol2qm74	7733	23	survival	survival	NN
cord-015021-pol2qm74	7733	24	has	have	VBZ
cord-015021-pol2qm74	7733	25	to	to	TO
cord-015021-pol2qm74	7733	26	be	be	VB
cord-015021-pol2qm74	7733	27	investigated	investigate	VBN
cord-015021-pol2qm74	7733	28	in	in	IN
cord-015021-pol2qm74	7733	29	double	double	JJ
cord-015021-pol2qm74	7733	30	-	-	HYPH
cord-015021-pol2qm74	7733	31	blind	blind	JJ
cord-015021-pol2qm74	7733	32	,	,	,
cord-015021-pol2qm74	7733	33	placebocontrolled	placebocontrolled	JJ
cord-015021-pol2qm74	7733	34	studies	study	NNS
cord-015021-pol2qm74	7733	35	.	.	.
cord-015021-pol2qm74	7734	1	SALUTARY	salutary	JJ
cord-015021-pol2qm74	7734	2	EFFECT	effect	NN
cord-015021-pol2qm74	7734	3	OF	of	IN
cord-015021-pol2qm74	7734	4	HUMAN	human	NN
cord-015021-pol2qm74	7734	5	SOLUBLE	SOLUBLE	NNP
cord-015021-pol2qm74	7734	6	COMPLEMENT	complement	VBP
cord-015021-pol2qm74	7734	7	RECEPTOR	receptor	NN
cord-015021-pol2qm74	7734	8	TYPE-1	type-1	NN
cord-015021-pol2qm74	7734	9	IN	in	IN
cord-015021-pol2qm74	7734	10	MODELS	model	NNS
cord-015021-pol2qm74	7734	11	OF	of	IN
cord-015021-pol2qm74	7735	1	ADULT	adult	JJ
cord-015021-pol2qm74	7735	2	RESPIRATORY	respiratory	JJ
cord-015021-pol2qm74	7735	3	DISTRESS	distress	NN
cord-015021-pol2qm74	7735	4	SYNDROME	syndrome	NN
cord-015021-pol2qm74	7735	5	G.	G.	NNP
cord-015021-pol2qm74	7735	6	Feuerstein	Feuerstein	NNP
cord-015021-pol2qm74	7735	7	,	,	,
cord-015021-pol2qm74	7735	8	M.	M.	NNP
cord-015021-pol2qm74	7735	9	DiMartino	DiMartino	NNP
cord-015021-pol2qm74	7735	10	,	,	,
cord-015021-pol2qm74	7735	11	and	and	CC
cord-015021-pol2qm74	7735	12	*	*	NFP
cord-015021-pol2qm74	7735	13	R.	R.	NNP
cord-015021-pol2qm74	7735	14	Rabinovici	Rabinovici	NNP
cord-015021-pol2qm74	7735	15	,	,	,
cord-015021-pol2qm74	7735	16	SmithKline	SmithKline	NNP
cord-015021-pol2qm74	7735	17	Beecham	Beecham	NNP
cord-015021-pol2qm74	7735	18	Pharmaceuticals	Pharmaceuticals	NNP
cord-015021-pol2qm74	7735	19	,	,	,
cord-015021-pol2qm74	7735	20	King	King	NNP
cord-015021-pol2qm74	7735	21	of	of	IN
cord-015021-pol2qm74	7735	22	Prussia	Prussia	NNP
cord-015021-pol2qm74	7735	23	,	,	,
cord-015021-pol2qm74	7735	24	PA	PA	NNP
cord-015021-pol2qm74	7735	25	,	,	,
cord-015021-pol2qm74	7735	26	USA	USA	NNP
cord-015021-pol2qm74	7735	27	,	,	,
cord-015021-pol2qm74	7735	28	and	and	CC
cord-015021-pol2qm74	7735	29	*	*	NFP
cord-015021-pol2qm74	7735	30	Jefferson	Jefferson	NNP
cord-015021-pol2qm74	7735	31	Medical	Medical	NNP
cord-015021-pol2qm74	7735	32	College	College	NNP
cord-015021-pol2qm74	7735	33	,	,	,
cord-015021-pol2qm74	7735	34	Philadelphia	Philadelphia	NNP
cord-015021-pol2qm74	7735	35	,	,	,
cord-015021-pol2qm74	7735	36	PA	PA	NNP
cord-015021-pol2qm74	7735	37	,	,	,
cord-015021-pol2qm74	7736	1	USA	USA	NNP
cord-015021-pol2qm74	7736	2	Adult	Adult	NNP
cord-015021-pol2qm74	7736	3	Respiratory	Respiratory	NNP
cord-015021-pol2qm74	7736	4	Distress	Distress	NNP
cord-015021-pol2qm74	7736	5	Syndrome	Syndrome	NNP
cord-015021-pol2qm74	7736	6	(	(	-LRB-
cord-015021-pol2qm74	7736	7	ARDS	ARDS	NNP
cord-015021-pol2qm74	7736	8	)	)	-RRB-
cord-015021-pol2qm74	7736	9	is	be	VBZ
cord-015021-pol2qm74	7736	10	a	a	DT
cord-015021-pol2qm74	7736	11	severe	severe	JJ
cord-015021-pol2qm74	7736	12	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7736	13	insufficiency	insufficiency	NN
cord-015021-pol2qm74	7736	14	syndrome	syndrome	NN
cord-015021-pol2qm74	7736	15	associated	associate	VBN
cord-015021-pol2qm74	7736	16	with	with	IN
cord-015021-pol2qm74	7736	17	diverse	diverse	JJ
cord-015021-pol2qm74	7736	18	diseases	disease	NNS
cord-015021-pol2qm74	7736	19	and	and	CC
cord-015021-pol2qm74	7736	20	injuries	injury	NNS
cord-015021-pol2qm74	7736	21	.	.	.
cord-015021-pol2qm74	7737	1	ARDS	ARDS	NNP
cord-015021-pol2qm74	7737	2	is	be	VBZ
cord-015021-pol2qm74	7737	3	believed	believe	VBN
cord-015021-pol2qm74	7737	4	to	to	TO
cord-015021-pol2qm74	7737	5	be	be	VB
cord-015021-pol2qm74	7737	6	the	the	DT
cord-015021-pol2qm74	7737	7	consequence	consequence	NN
cord-015021-pol2qm74	7737	8	of	of	IN
cord-015021-pol2qm74	7737	9	a	a	DT
cord-015021-pol2qm74	7737	10	massive	massive	JJ
cord-015021-pol2qm74	7737	11	acute	acute	JJ
cord-015021-pol2qm74	7737	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7737	13	reaction	reaction	NN
cord-015021-pol2qm74	7737	14	consisting	consist	VBG
cord-015021-pol2qm74	7737	15	of	of	IN
cord-015021-pol2qm74	7737	16	activated	activate	VBN
cord-015021-pol2qm74	7737	17	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7737	18	infiltration	infiltration	NN
cord-015021-pol2qm74	7737	19	into	into	IN
cord-015021-pol2qm74	7737	20	the	the	DT
cord-015021-pol2qm74	7737	21	lung	lung	NN
cord-015021-pol2qm74	7737	22	.	.	.
cord-015021-pol2qm74	7738	1	Neutrophil	Neutrophil	NNP
cord-015021-pol2qm74	7738	2	activation	activation	NN
cord-015021-pol2qm74	7738	3	is	be	VBZ
cord-015021-pol2qm74	7738	4	likely	likely	RB
cord-015021-pol2qm74	7738	5	the	the	DT
cord-015021-pol2qm74	7738	6	result	result	NN
cord-015021-pol2qm74	7738	7	of	of	IN
cord-015021-pol2qm74	7738	8	multiple	multiple	JJ
cord-015021-pol2qm74	7738	9	factors	factor	NNS
cord-015021-pol2qm74	7738	10	of	of	IN
cord-015021-pol2qm74	7738	11	which	which	WDT
cord-015021-pol2qm74	7738	12	complement	complement	NN
cord-015021-pol2qm74	7738	13	is	be	VBZ
cord-015021-pol2qm74	7738	14	believed	believe	VBN
cord-015021-pol2qm74	7738	15	to	to	TO
cord-015021-pol2qm74	7738	16	play	play	VB
cord-015021-pol2qm74	7738	17	a	a	DT
cord-015021-pol2qm74	7738	18	major	major	JJ
cord-015021-pol2qm74	7738	19	role	role	NN
cord-015021-pol2qm74	7738	20	.	.	.
cord-015021-pol2qm74	7739	1	A	a	DT
cord-015021-pol2qm74	7739	2	potent	potent	JJ
cord-015021-pol2qm74	7739	3	complement	complement	NN
cord-015021-pol2qm74	7739	4	regulatory	regulatory	JJ
cord-015021-pol2qm74	7739	5	system	system	NN
cord-015021-pol2qm74	7739	6	in	in	IN
cord-015021-pol2qm74	7739	7	the	the	DT
cord-015021-pol2qm74	7739	8	form	form	NN
cord-015021-pol2qm74	7739	9	of	of	IN
cord-015021-pol2qm74	7739	10	the	the	DT
cord-015021-pol2qm74	7739	11	Complement	Complement	NNP
cord-015021-pol2qm74	7739	12	Receptor	Receptor	NNP
cord-015021-pol2qm74	7739	13	Type-1	type-1	NN
cord-015021-pol2qm74	7740	1	(	(	-LRB-
cord-015021-pol2qm74	7740	2	CR-1	CR-1	NNP
cord-015021-pol2qm74	7740	3	)	)	-RRB-
cord-015021-pol2qm74	7740	4	exists	exist	VBZ
cord-015021-pol2qm74	7740	5	on	on	IN
cord-015021-pol2qm74	7740	6	many	many	JJ
cord-015021-pol2qm74	7740	7	cells	cell	NNS
cord-015021-pol2qm74	7740	8	where	where	WRB
cord-015021-pol2qm74	7740	9	protection	protection	NN
cord-015021-pol2qm74	7740	10	against	against	IN
cord-015021-pol2qm74	7740	11	complement	complement	JJ
cord-015021-pol2qm74	7740	12	injury	injury	NN
cord-015021-pol2qm74	7740	13	is	be	VBZ
cord-015021-pol2qm74	7740	14	provided	provide	VBN
cord-015021-pol2qm74	7740	15	by	by	IN
cord-015021-pol2qm74	7740	16	inhibition	inhibition	NN
cord-015021-pol2qm74	7740	17	of	of	IN
cord-015021-pol2qm74	7740	18	both	both	CC
cord-015021-pol2qm74	7740	19	the	the	DT
cord-015021-pol2qm74	7740	20	alternative	alternative	JJ
cord-015021-pol2qm74	7740	21	and	and	CC
cord-015021-pol2qm74	7740	22	classical	classical	JJ
cord-015021-pol2qm74	7740	23	pathways	pathway	NNS
cord-015021-pol2qm74	7740	24	for	for	IN
cord-015021-pol2qm74	7740	25	C3	C3	NNP
cord-015021-pol2qm74	7740	26	/	/	SYM
cord-015021-pol2qm74	7740	27	C5	c5	NN
cord-015021-pol2qm74	7740	28	convertase	convertase	NN
cord-015021-pol2qm74	7740	29	formation	formation	NN
cord-015021-pol2qm74	7740	30	.	.	.
cord-015021-pol2qm74	7741	1	We	-PRON-	PRP
cord-015021-pol2qm74	7741	2	have	have	VBP
cord-015021-pol2qm74	7741	3	recently	recently	RB
cord-015021-pol2qm74	7741	4	purified	purify	VBN
cord-015021-pol2qm74	7741	5	the	the	DT
cord-015021-pol2qm74	7741	6	human	human	JJ
cord-015021-pol2qm74	7741	7	recombinant	recombinant	JJ
cord-015021-pol2qm74	7741	8	CR-1	CR-1	NNP
cord-015021-pol2qm74	7741	9	in	in	IN
cord-015021-pol2qm74	7741	10	a	a	DT
cord-015021-pol2qm74	7741	11	truncated	truncated	JJ
cord-015021-pol2qm74	7741	12	form	form	NN
cord-015021-pol2qm74	7741	13	(	(	-LRB-
cord-015021-pol2qm74	7741	14	BRL55730	brl55730	NN
cord-015021-pol2qm74	7741	15	,	,	,
cord-015021-pol2qm74	7741	16	TP	TP	NNP
cord-015021-pol2qm74	7741	17	-	-	HYPH
cord-015021-pol2qm74	7741	18	IO	IO	NNP
cord-015021-pol2qm74	7741	19	,	,	,
cord-015021-pol2qm74	7741	20	sCR-1	sCR-1	NNP
cord-015021-pol2qm74	7741	21	)	)	-RRB-
cord-015021-pol2qm74	7741	22	and	and	CC
cord-015021-pol2qm74	7741	23	tested	test	VBD
cord-015021-pol2qm74	7741	24	this	this	DT
cord-015021-pol2qm74	7741	25	soluble	soluble	JJ
cord-015021-pol2qm74	7741	26	protein	protein	NN
cord-015021-pol2qm74	7741	27	for	for	IN
cord-015021-pol2qm74	7741	28	protective	protective	JJ
cord-015021-pol2qm74	7741	29	effects	effect	NNS
cord-015021-pol2qm74	7741	30	in	in	IN
cord-015021-pol2qm74	7741	31	several	several	JJ
cord-015021-pol2qm74	7741	32	models	model	NNS
cord-015021-pol2qm74	7741	33	of	of	IN
cord-015021-pol2qm74	7741	34	ARDS	ARDS	NNP
cord-015021-pol2qm74	7741	35	.	.	.
cord-015021-pol2qm74	7742	1	Specifically	specifically	RB
cord-015021-pol2qm74	7742	2	,	,	,
cord-015021-pol2qm74	7742	3	we	-PRON-	PRP
cord-015021-pol2qm74	7742	4	have	have	VBP
cord-015021-pol2qm74	7742	5	used	use	VBN
cord-015021-pol2qm74	7742	6	the	the	DT
cord-015021-pol2qm74	7742	7	following	follow	VBG
cord-015021-pol2qm74	7742	8	rat	rat	NN
cord-015021-pol2qm74	7742	9	models	model	NNS
cord-015021-pol2qm74	7742	10	:	:	:
cord-015021-pol2qm74	7743	1	1	1	LS
cord-015021-pol2qm74	7743	2	)	)	-RRB-
cord-015021-pol2qm74	7743	3	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7743	4	-	-	HYPH
cord-015021-pol2qm74	7743	5	induced	induce	VBN
cord-015021-pol2qm74	7743	6	ARDS	ARDS	NNP
cord-015021-pol2qm74	7743	7	in	in	IN
cord-015021-pol2qm74	7743	8	PAF	PAF	NNP
cord-015021-pol2qm74	7743	9	primed	prime	VBN
cord-015021-pol2qm74	7743	10	animals	animal	NNS
cord-015021-pol2qm74	7743	11	;	;	:
cord-015021-pol2qm74	7743	12	2	2	LS
cord-015021-pol2qm74	7743	13	)	)	-RRB-
cord-015021-pol2qm74	7743	14	11.-2induced	11.-2induced	CD
cord-015021-pol2qm74	7743	15	ARDS	ARDS	NNP
cord-015021-pol2qm74	7743	16	;	;	:
cord-015021-pol2qm74	7743	17	3	3	LS
cord-015021-pol2qm74	7743	18	)	)	-RRB-
cord-015021-pol2qm74	7743	19	thermal	thermal	JJ
cord-015021-pol2qm74	7743	20	injury	injury	NN
cord-015021-pol2qm74	7743	21	(	(	-LRB-
cord-015021-pol2qm74	7743	22	30	30	CD
cord-015021-pol2qm74	7743	23	%	%	NN
cord-015021-pol2qm74	7743	24	body	body	NN
cord-015021-pol2qm74	7743	25	surface)-induced	surface)-induced	NNP
cord-015021-pol2qm74	7743	26	ARDS	ARDS	NNP
cord-015021-pol2qm74	7743	27	;	;	:
cord-015021-pol2qm74	7743	28	4	4	LS
cord-015021-pol2qm74	7743	29	)	)	-RRB-
cord-015021-pol2qm74	7743	30	acid	acid	JJ
cord-015021-pol2qm74	7743	31	aspiration	aspiration	NN
cord-015021-pol2qm74	7743	32	-	-	HYPH
cord-015021-pol2qm74	7743	33	induced	induce	VBN
cord-015021-pol2qm74	7743	34	ARDS	ARDS	NNP
cord-015021-pol2qm74	7743	35	.	.	.
cord-015021-pol2qm74	7744	1	ARDS	ARDS	NNP
cord-015021-pol2qm74	7744	2	-	-	HYPH
cord-015021-pol2qm74	7744	3	like	like	JJ
cord-015021-pol2qm74	7744	4	features	feature	NNS
cord-015021-pol2qm74	7744	5	included	include	VBN
cord-015021-pol2qm74	7744	6	edema	edema	NN
cord-015021-pol2qm74	7744	7	(	(	-LRB-
cord-015021-pol2qm74	7744	8	increase	increase	NN
cord-015021-pol2qm74	7744	9	in	in	IN
cord-015021-pol2qm74	7744	10	lung	lung	NN
cord-015021-pol2qm74	7744	11	wet	wet	JJ
cord-015021-pol2qm74	7744	12	weight	weight	NN
cord-015021-pol2qm74	7744	13	and	and	CC
cord-015021-pol2qm74	7744	14	water	water	NN
cord-015021-pol2qm74	7744	15	content	content	NN
cord-015021-pol2qm74	7744	16	)	)	-RRB-
cord-015021-pol2qm74	7744	17	,	,	,
cord-015021-pol2qm74	7744	18	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7744	19	accumulation	accumulation	NN
cord-015021-pol2qm74	7744	20	(	(	-LRB-
cord-015021-pol2qm74	7744	21	histological	histological	JJ
cord-015021-pol2qm74	7744	22	inspection	inspection	NN
cord-015021-pol2qm74	7744	23	and	and	CC
cord-015021-pol2qm74	7744	24	myeloperoxidase	myeloperoxidase	NN
cord-015021-pol2qm74	7744	25	assay	assay	NN
cord-015021-pol2qm74	7744	26	)	)	-RRB-
cord-015021-pol2qm74	7744	27	and	and	CC
cord-015021-pol2qm74	7744	28	increase	increase	NN
cord-015021-pol2qm74	7744	29	in	in	IN
cord-015021-pol2qm74	7744	30	cells	cell	NNS
cord-015021-pol2qm74	7744	31	and	and	CC
cord-015021-pol2qm74	7744	32	protein	protein	NN
cord-015021-pol2qm74	7744	33	in	in	IN
cord-015021-pol2qm74	7744	34	the	the	DT
cord-015021-pol2qm74	7744	35	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	7744	36	lavage	lavage	NN
cord-015021-pol2qm74	7744	37	(	(	-LRB-
cord-015021-pol2qm74	7744	38	BAD	bad	JJ
cord-015021-pol2qm74	7744	39	.	.	.
cord-015021-pol2qm74	7745	1	sCR-1	sCR-1	NNP
cord-015021-pol2qm74	7745	2	,	,	,
cord-015021-pol2qm74	7745	3	1	1	CD
cord-015021-pol2qm74	7745	4	-	-	SYM
cord-015021-pol2qm74	7745	5	25	25	CD
cord-015021-pol2qm74	7745	6	mg	mg	NNP
cord-015021-pol2qm74	7745	7	/	/	SYM
cord-015021-pol2qm74	7745	8	kg	kg	NNP
cord-015021-pol2qm74	7745	9	,	,	,
cord-015021-pol2qm74	7745	10	i	i	PRP
cord-015021-pol2qm74	7745	11	,	,	,
cord-015021-pol2qm74	7745	12	v	v	NNP
cord-015021-pol2qm74	7745	13	.	.	NNP
cord-015021-pol2qm74	7745	14	,	,	,
cord-015021-pol2qm74	7745	15	given	give	VBN
cord-015021-pol2qm74	7745	16	as	as	IN
cord-015021-pol2qm74	7745	17	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	7745	18	(	(	-LRB-
cord-015021-pol2qm74	7745	19	and	and	CC
cord-015021-pol2qm74	7745	20	in	in	IN
cord-015021-pol2qm74	7745	21	some	some	DT
cord-015021-pol2qm74	7745	22	cases	case	NNS
cord-015021-pol2qm74	7745	23	,	,	,
cord-015021-pol2qm74	7745	24	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7745	25	)	)	-RRB-
cord-015021-pol2qm74	7745	26	treatment	treatment	NN
cord-015021-pol2qm74	7745	27	significantly	significantly	RB
cord-015021-pol2qm74	7745	28	inhibited	inhibit	VBD
cord-015021-pol2qm74	7745	29	edema	edema	NN
cord-015021-pol2qm74	7745	30	formation	formation	NN
cord-015021-pol2qm74	7745	31	and	and	CC
cord-015021-pol2qm74	7745	32	leukocyte	leukocyte	NN
cord-015021-pol2qm74	7745	33	infiltration	infiltration	NN
cord-015021-pol2qm74	7745	34	and	and	CC
cord-015021-pol2qm74	7745	35	,	,	,
cord-015021-pol2qm74	7745	36	in	in	IN
cord-015021-pol2qm74	7745	37	some	some	DT
cord-015021-pol2qm74	7745	38	cases	case	NNS
cord-015021-pol2qm74	7745	39	(	(	-LRB-
cord-015021-pol2qm74	7745	40	e.g.	e.g.	RB
cord-015021-pol2qm74	7745	41	,	,	,
cord-015021-pol2qm74	7745	42	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7745	43	/	/	SYM
cord-015021-pol2qm74	7745	44	PAF	PAF	NNP
cord-015021-pol2qm74	7745	45	or	or	CC
cord-015021-pol2qm74	7745	46	IL-2	IL-2	NNP
cord-015021-pol2qm74	7745	47	)	)	-RRB-
cord-015021-pol2qm74	7745	48	,	,	,
cord-015021-pol2qm74	7745	49	virtually	virtually	RB
cord-015021-pol2qm74	7745	50	completely	completely	RB
cord-015021-pol2qm74	7745	51	.	.	.
cord-015021-pol2qm74	7746	1	These	these	DT
cord-015021-pol2qm74	7746	2	comprehensive	comprehensive	JJ
cord-015021-pol2qm74	7746	3	studies	study	NNS
cord-015021-pol2qm74	7746	4	strongly	strongly	RB
cord-015021-pol2qm74	7746	5	support	support	VBP
cord-015021-pol2qm74	7746	6	the	the	DT
cord-015021-pol2qm74	7746	7	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7746	8	potential	potential	NN
cord-015021-pol2qm74	7746	9	of	of	IN
cord-015021-pol2qm74	7746	10	sCR-1	sCR-1	NNP
cord-015021-pol2qm74	7746	11	in	in	IN
cord-015021-pol2qm74	7746	12	ARDS	ARDS	NNP
cord-015021-pol2qm74	7746	13	due	due	IN
cord-015021-pol2qm74	7746	14	to	to	IN
cord-015021-pol2qm74	7746	15	diverse	diverse	JJ
cord-015021-pol2qm74	7746	16	injuries	injury	NNS
cord-015021-pol2qm74	7746	17	.	.	.
cord-015021-pol2qm74	7747	1	The	the	DT
cord-015021-pol2qm74	7747	2	xanthine	xanthine	NN
cord-015021-pol2qm74	7747	3	derivative	derivative	JJ
cord-015021-pol2qm74	7747	4	pentoxifylline	pentoxifylline	NN
cord-015021-pol2qm74	7747	5	(	(	-LRB-
cord-015021-pol2qm74	7747	6	PTX	PTX	NNP
cord-015021-pol2qm74	7747	7	)	)	-RRB-
cord-015021-pol2qm74	7747	8	and	and	CC
cord-015021-pol2qm74	7747	9	several	several	JJ
cord-015021-pol2qm74	7747	10	analogs	analog	NNS
cord-015021-pol2qm74	7747	11	of	of	IN
cord-015021-pol2qm74	7747	12	PTX	PTX	NNP
cord-015021-pol2qm74	7747	13	have	have	VBP
cord-015021-pol2qm74	7747	14	been	be	VBN
cord-015021-pol2qm74	7747	15	evaluated	evaluate	VBN
cord-015021-pol2qm74	7747	16	for	for	IN
cord-015021-pol2qm74	7747	17	their	-PRON-	PRP$
cord-015021-pol2qm74	7747	18	protective	protective	JJ
cord-015021-pol2qm74	7747	19	effect	effect	NN
cord-015021-pol2qm74	7747	20	in	in	IN
cord-015021-pol2qm74	7747	21	various	various	JJ
cord-015021-pol2qm74	7747	22	animal	animal	NN
cord-015021-pol2qm74	7747	23	models	model	NNS
cord-015021-pol2qm74	7747	24	of	of	IN
cord-015021-pol2qm74	7747	25	septic	septic	JJ
cord-015021-pol2qm74	7747	26	shock	shock	NN
cord-015021-pol2qm74	7747	27	.	.	.
cord-015021-pol2qm74	7748	1	Data	datum	NNS
cord-015021-pol2qm74	7748	2	from	from	IN
cord-015021-pol2qm74	7748	3	these	these	DT
cord-015021-pol2qm74	7748	4	in	in	IN
cord-015021-pol2qm74	7748	5	vivo	vivo	NN
cord-015021-pol2qm74	7748	6	studies	study	NNS
cord-015021-pol2qm74	7748	7	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	7748	8	that	that	DT
cord-015021-pol2qm74	7748	9	(	(	-LRB-
cord-015021-pol2qm74	7748	10	1	1	CD
cord-015021-pol2qm74	7748	11	)	)	-RRB-
cord-015021-pol2qm74	7748	12	PTX	PTX	NNP
cord-015021-pol2qm74	7748	13	suppresses	suppress	VBZ
cord-015021-pol2qm74	7748	14	LPS	LPS	NNP
cord-015021-pol2qm74	7748	15	-	-	HYPH
cord-015021-pol2qm74	7748	16	induced	induce	VBN
cord-015021-pol2qm74	7748	17	TNF	TNF	NNP
cord-015021-pol2qm74	7748	18	release	release	NN
cord-015021-pol2qm74	7748	19	from	from	IN
cord-015021-pol2qm74	7748	20	activated	activate	VBN
cord-015021-pol2qm74	7748	21	macrophages	macrophage	NNS
cord-015021-pol2qm74	7748	22	;	;	,
cord-015021-pol2qm74	7748	23	(	(	-LRB-
cord-015021-pol2qm74	7748	24	2	2	LS
cord-015021-pol2qm74	7748	25	)	)	-RRB-
cord-015021-pol2qm74	7748	26	PTX	PTX	NNP
cord-015021-pol2qm74	7748	27	prevents	prevent	VBZ
cord-015021-pol2qm74	7748	28	TNF	TNF	NNP
cord-015021-pol2qm74	7748	29	-	-	HYPH
cord-015021-pol2qm74	7748	30	induced	induce	VBN
cord-015021-pol2qm74	7748	31	PMN	PMN	NNP
cord-015021-pol2qm74	7748	32	activation	activation	NN
cord-015021-pol2qm74	7748	33	;	;	:
cord-015021-pol2qm74	7748	34	(	(	-LRB-
cord-015021-pol2qm74	7748	35	3	3	CD
cord-015021-pol2qm74	7748	36	)	)	-RRB-
cord-015021-pol2qm74	7748	37	PTX	PTX	NNP
cord-015021-pol2qm74	7748	38	attenuates	attenuate	VBZ
cord-015021-pol2qm74	7748	39	LPS	LPS	NNP
cord-015021-pol2qm74	7748	40	-	-	HYPH
cord-015021-pol2qm74	7748	41	or	or	CC
cord-015021-pol2qm74	7748	42	TNFinduced	tnfinduced	JJ
cord-015021-pol2qm74	7748	43	acute	acute	JJ
cord-015021-pol2qm74	7748	44	lung	lung	NN
cord-015021-pol2qm74	7748	45	injury	injury	NN
cord-015021-pol2qm74	7748	46	as	as	IN
cord-015021-pol2qm74	7748	47	evidenced	evidence	VBN
cord-015021-pol2qm74	7748	48	by	by	IN
cord-015021-pol2qm74	7748	49	prevention	prevention	NN
cord-015021-pol2qm74	7748	50	of	of	IN
cord-015021-pol2qm74	7748	51	increased	increase	VBN
cord-015021-pol2qm74	7748	52	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7748	53	vascular	vascular	JJ
cord-015021-pol2qm74	7748	54	permeability	permeability	NN
cord-015021-pol2qm74	7748	55	and	and	CC
cord-015021-pol2qm74	7748	56	detoriation	detoriation	NN
cord-015021-pol2qm74	7748	57	of	of	IN
cord-015021-pol2qm74	7748	58	gas	gas	NN
cord-015021-pol2qm74	7748	59	exchange	exchange	NN
cord-015021-pol2qm74	7748	60	;	;	,
cord-015021-pol2qm74	7748	61	(	(	-LRB-
cord-015021-pol2qm74	7748	62	4	4	LS
cord-015021-pol2qm74	7748	63	)	)	-RRB-
cord-015021-pol2qm74	7748	64	PTX	PTX	NNP
cord-015021-pol2qm74	7748	65	exerts	exert	VBZ
cord-015021-pol2qm74	7748	66	its	-PRON-	PRP$
cord-015021-pol2qm74	7748	67	.protective	.protective	CD
cord-015021-pol2qm74	7748	68	effects	effect	NNS
cord-015021-pol2qm74	7748	69	even	even	RB
cord-015021-pol2qm74	7748	70	when	when	WRB
cord-015021-pol2qm74	7748	71	administered	administer	VBN
cord-015021-pol2qm74	7748	72	following	follow	VBG
cord-015021-pol2qm74	7748	73	initiation	initiation	NN
cord-015021-pol2qm74	7748	74	of	of	IN
cord-015021-pol2qm74	7748	75	sepsis	sepsis	NN
cord-015021-pol2qm74	7748	76	.	.	.
cord-015021-pol2qm74	7749	1	The	the	DT
cord-015021-pol2qm74	7749	2	sum	sum	NN
cord-015021-pol2qm74	7749	3	of	of	IN
cord-015021-pol2qm74	7749	4	these	these	DT
cord-015021-pol2qm74	7749	5	actions	action	NNS
cord-015021-pol2qm74	7749	6	suggest	suggest	VBP
cord-015021-pol2qm74	7749	7	that	that	IN
cord-015021-pol2qm74	7749	8	administration	administration	NN
cord-015021-pol2qm74	7749	9	of	of	IN
cord-015021-pol2qm74	7749	10	PTX	PTX	NNP
cord-015021-pol2qm74	7749	11	in	in	IN
cord-015021-pol2qm74	7749	12	sepsis	sepsis	NN
cord-015021-pol2qm74	7749	13	may	may	MD
cord-015021-pol2qm74	7749	14	have	have	VB
cord-015021-pol2qm74	7749	15	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7749	16	potential	potential	NN
cord-015021-pol2qm74	7749	17	.	.	.
cord-015021-pol2qm74	7750	1	Hans	Hans	NNP
cord-015021-pol2qm74	7750	2	Hoffmann	Hoffmann	NNP
cord-015021-pol2qm74	7750	3	MD	MD	NNP
cord-015021-pol2qm74	7750	4	,	,	,
cord-015021-pol2qm74	7750	5	Dept	Dept	NNP
cord-015021-pol2qm74	7750	6	.	.	NNP
cord-015021-pol2qm74	7750	7	of	of	IN
cord-015021-pol2qm74	7750	8	Surgery	surgery	NN
cord-015021-pol2qm74	7750	9	,	,	,
cord-015021-pol2qm74	7750	10	Klinikum	Klinikum	NNP
cord-015021-pol2qm74	7750	11	Grosshadern	Grosshadern	NNP
cord-015021-pol2qm74	7750	12	,	,	,
cord-015021-pol2qm74	7750	13	Ludwig	Ludwig	NNP
cord-015021-pol2qm74	7750	14	-	-	HYPH
cord-015021-pol2qm74	7750	15	Maximilians	Maximilians	NNPS
cord-015021-pol2qm74	7750	16	-	-	HYPH
cord-015021-pol2qm74	7750	17	Universit~.t	Universit~.t	NNS
cord-015021-pol2qm74	7750	18	,	,	,
cord-015021-pol2qm74	7750	19	MarchioninJstrasse	MarchioninJstrasse	NNP
cord-015021-pol2qm74	7750	20	15	15	CD
cord-015021-pol2qm74	7750	21	,	,	,
cord-015021-pol2qm74	7751	1	D-81377	D-81377	NNS
cord-015021-pol2qm74	7752	1	M0nchen	M0nchen	NNP
cord-015021-pol2qm74	7752	2	,	,	,
cord-015021-pol2qm74	7752	3	Germany	Germany	NNP
cord-015021-pol2qm74	7752	4	.	.	.
cord-015021-pol2qm74	7753	1	Pentoxifylline	Pentoxifylline	NNP
cord-015021-pol2qm74	7753	2	[	[	-LRB-
cord-015021-pol2qm74	7753	3	POF	POF	NNP
cord-015021-pol2qm74	7753	4	]	]	-RRB-
cord-015021-pol2qm74	7753	5	and	and	CC
cord-015021-pol2qm74	7753	6	related	relate	VBN
cord-015021-pol2qm74	7753	7	xanthins	xanthin	NNS
cord-015021-pol2qm74	7753	8	are	be	VBP
cord-015021-pol2qm74	7753	9	drugs	drug	NNS
cord-015021-pol2qm74	7753	10	of	of	IN
cord-015021-pol2qm74	7753	11	known	know	VBN
cord-015021-pol2qm74	7753	12	haemorrheologieal	haemorrheologieal	NN
cord-015021-pol2qm74	7753	13	activity	activity	NN
cord-015021-pol2qm74	7753	14	and	and	CC
cord-015021-pol2qm74	7753	15	widely	widely	RB
cord-015021-pol2qm74	7753	16	used	use	VBN
cord-015021-pol2qm74	7753	17	clinically	clinically	RB
cord-015021-pol2qm74	7753	18	.	.	.
cord-015021-pol2qm74	7754	1	Recently	recently	RB
cord-015021-pol2qm74	7754	2	,	,	,
cord-015021-pol2qm74	7754	3	new	new	JJ
cord-015021-pol2qm74	7754	4	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	7754	5	aspects	aspect	NNS
cord-015021-pol2qm74	7754	6	of	of	IN
cord-015021-pol2qm74	7754	7	these	these	DT
cord-015021-pol2qm74	7754	8	established	establish	VBN
cord-015021-pol2qm74	7754	9	drugs	drug	NNS
cord-015021-pol2qm74	7754	10	could	could	MD
cord-015021-pol2qm74	7754	11	be	be	VB
cord-015021-pol2qm74	7754	12	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7754	13	.	.	.
cord-015021-pol2qm74	7755	1	It	-PRON-	PRP
cord-015021-pol2qm74	7755	2	was	be	VBD
cord-015021-pol2qm74	7755	3	found	find	VBN
cord-015021-pol2qm74	7755	4	that	that	IN
cord-015021-pol2qm74	7755	5	POF	POF	NNP
cord-015021-pol2qm74	7755	6	selectively	selectively	RB
cord-015021-pol2qm74	7755	7	inhibits	inhibit	VBZ
cord-015021-pol2qm74	7755	8	the	the	DT
cord-015021-pol2qm74	7755	9	formation	formation	NN
cord-015021-pol2qm74	7755	10	of	of	IN
cord-015021-pol2qm74	7755	11	TNF	TNF	NNP
cord-015021-pol2qm74	7755	12	but	but	CC
cord-015021-pol2qm74	7755	13	not	not	RB
cord-015021-pol2qm74	7755	14	IL-6	IL-6	NNP
cord-015021-pol2qm74	7755	15	most	most	RBS
cord-015021-pol2qm74	7755	16	likely	likely	JJ
cord-015021-pol2qm74	7755	17	by	by	IN
cord-015021-pol2qm74	7755	18	causing	cause	VBG
cord-015021-pol2qm74	7755	19	accumulation	accumulation	NN
cord-015021-pol2qm74	7755	20	of	of	IN
cord-015021-pol2qm74	7755	21	intraceliular	intraceliular	NNP
cord-015021-pol2qm74	7755	22	cAMP	cAMP	NNP
cord-015021-pol2qm74	7755	23	via	via	IN
cord-015021-pol2qm74	7755	24	inhibiting	inhibit	VBG
cord-015021-pol2qm74	7755	25	phosphodiestersse	phosphodiestersse	NN
cord-015021-pol2qm74	7755	26	activity	activity	NN
cord-015021-pol2qm74	7755	27	,	,	,
cord-015021-pol2qm74	7755	28	and	and	CC
cord-015021-pol2qm74	7755	29	,	,	,
cord-015021-pol2qm74	7755	30	secondly	secondly	RB
cord-015021-pol2qm74	7755	31	,	,	,
cord-015021-pol2qm74	7755	32	by	by	IN
cord-015021-pol2qm74	7755	33	inducing	induce	VBG
cord-015021-pol2qm74	7755	34	prostacyclin	prostacyclin	NNP
cord-015021-pol2qm74	7755	35	in	in	IN
cord-015021-pol2qm74	7755	36	different	different	JJ
cord-015021-pol2qm74	7755	37	cell	cell	NN
cord-015021-pol2qm74	7755	38	types	type	NNS
cord-015021-pol2qm74	7755	39	.	.	.
cord-015021-pol2qm74	7756	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	7756	2	,	,	,
cord-015021-pol2qm74	7756	3	POF	POF	NNP
cord-015021-pol2qm74	7756	4	is	be	VBZ
cord-015021-pol2qm74	7756	5	able	able	JJ
cord-015021-pol2qm74	7756	6	to	to	TO
cord-015021-pol2qm74	7756	7	counteract	counteract	VB
cord-015021-pol2qm74	7756	8	TNF	TNF	NNP
cord-015021-pol2qm74	7756	9	-	-	HYPH
cord-015021-pol2qm74	7756	10	mediated	mediate	VBN
cord-015021-pol2qm74	7756	11	adherence	adherence	NN
cord-015021-pol2qm74	7756	12	of	of	IN
cord-015021-pol2qm74	7756	13	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7756	14	to	to	IN
cord-015021-pol2qm74	7756	15	vascular	vascular	JJ
cord-015021-pol2qm74	7756	16	endothelium	endothelium	NN
cord-015021-pol2qm74	7756	17	and	and	CC
cord-015021-pol2qm74	7756	18	to	to	TO
cord-015021-pol2qm74	7756	19	inhibit	inhibit	VB
cord-015021-pol2qm74	7756	20	FMLP	FMLP	NNP
cord-015021-pol2qm74	7756	21	-	-	HYPH
cord-015021-pol2qm74	7756	22	indueed	indueed	NN
cord-015021-pol2qm74	7756	23	respiratory	respiratory	NN
cord-015021-pol2qm74	7756	24	burst	burst	NN
cord-015021-pol2qm74	7756	25	in	in	IN
cord-015021-pol2qm74	7756	26	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7756	27	.	.	.
cord-015021-pol2qm74	7757	1	We	-PRON-	PRP
cord-015021-pol2qm74	7757	2	and	and	CC
cord-015021-pol2qm74	7757	3	others	other	NNS
cord-015021-pol2qm74	7757	4	have	have	VBP
cord-015021-pol2qm74	7757	5	,	,	,
cord-015021-pol2qm74	7757	6	therefore	therefore	RB
cord-015021-pol2qm74	7757	7	,	,	,
cord-015021-pol2qm74	7757	8	studied	study	VBD
cord-015021-pol2qm74	7757	9	its	-PRON-	PRP$
cord-015021-pol2qm74	7757	10	effect	effect	NN
cord-015021-pol2qm74	7757	11	in	in	IN
cord-015021-pol2qm74	7757	12	different	different	JJ
cord-015021-pol2qm74	7757	13	animal	animal	NN
cord-015021-pol2qm74	7757	14	models	model	NNS
cord-015021-pol2qm74	7757	15	.	.	.
cord-015021-pol2qm74	7758	1	It	-PRON-	PRP
cord-015021-pol2qm74	7758	2	was	be	VBD
cord-015021-pol2qm74	7758	3	found	find	VBN
cord-015021-pol2qm74	7758	4	that	that	IN
cord-015021-pol2qm74	7758	5	POF	POF	NNP
cord-015021-pol2qm74	7758	6	protected	protect	VBN
cord-015021-pol2qm74	7758	7	from	from	IN
cord-015021-pol2qm74	7758	8	increased	increase	VBN
cord-015021-pol2qm74	7758	9	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7758	10	vascular	vascular	JJ
cord-015021-pol2qm74	7758	11	permeability	permeability	NN
cord-015021-pol2qm74	7758	12	and	and	CC
cord-015021-pol2qm74	7758	13	sequestration	sequestration	NN
cord-015021-pol2qm74	7758	14	of	of	IN
cord-015021-pol2qm74	7758	15	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7758	16	into	into	IN
cord-015021-pol2qm74	7758	17	the	the	DT
cord-015021-pol2qm74	7758	18	lung	lung	NN
cord-015021-pol2qm74	7758	19	in	in	IN
cord-015021-pol2qm74	7758	20	different	different	JJ
cord-015021-pol2qm74	7758	21	animal	animal	NN
cord-015021-pol2qm74	7758	22	models	model	NNS
cord-015021-pol2qm74	7758	23	of	of	IN
cord-015021-pol2qm74	7758	24	acute	acute	JJ
cord-015021-pol2qm74	7758	25	lung	lung	NN
cord-015021-pol2qm74	7758	26	injury	injury	NN
cord-015021-pol2qm74	7758	27	.	.	.
cord-015021-pol2qm74	7759	1	Moreover	moreover	RB
cord-015021-pol2qm74	7759	2	,	,	,
cord-015021-pol2qm74	7759	3	in	in	IN
cord-015021-pol2qm74	7759	4	pigs	pig	NNS
cord-015021-pol2qm74	7759	5	with	with	IN
cord-015021-pol2qm74	7759	6	induced	induce	VBN
cord-015021-pol2qm74	7759	7	faecal	faecal	JJ
cord-015021-pol2qm74	7759	8	peritonitis	peritonitis	NN
cord-015021-pol2qm74	7759	9	the	the	DT
cord-015021-pol2qm74	7759	10	drug	drug	NN
cord-015021-pol2qm74	7759	11	improved	improve	VBD
cord-015021-pol2qm74	7759	12	haemodyrmmle	haemodyrmmle	NN
cord-015021-pol2qm74	7759	13	variables	variable	NNS
cord-015021-pol2qm74	7759	14	as	as	RB
cord-015021-pol2qm74	7759	15	well	well	RB
cord-015021-pol2qm74	7759	16	as	as	IN
cord-015021-pol2qm74	7759	17	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7759	18	compliance	compliance	NN
cord-015021-pol2qm74	7759	19	and	and	CC
cord-015021-pol2qm74	7759	20	reduced	reduce	VBD
cord-015021-pol2qm74	7759	21	the	the	DT
cord-015021-pol2qm74	7759	22	number	number	NN
cord-015021-pol2qm74	7759	23	of	of	IN
cord-015021-pol2qm74	7759	24	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	7759	25	neutrophila	neutrophila	NN
cord-015021-pol2qm74	7759	26	and	and	CC
cord-015021-pol2qm74	7759	27	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	7759	28	.	.	.
cord-015021-pol2qm74	7760	1	Consequently	consequently	RB
cord-015021-pol2qm74	7760	2	,	,	,
cord-015021-pol2qm74	7760	3	as	as	IN
cord-015021-pol2qm74	7760	4	a	a	DT
cord-015021-pol2qm74	7760	5	general	general	JJ
cord-015021-pol2qm74	7760	6	outcome	outcome	NN
cord-015021-pol2qm74	7760	7	,	,	,
cord-015021-pol2qm74	7760	8	POF	POF	NNP
cord-015021-pol2qm74	7760	9	could	could	MD
cord-015021-pol2qm74	7760	10	be	be	VB
cord-015021-pol2qm74	7760	11	found	find	VBN
cord-015021-pol2qm74	7760	12	to	to	TO
cord-015021-pol2qm74	7760	13	improve	improve	VB
cord-015021-pol2qm74	7760	14	survival	survival	NN
cord-015021-pol2qm74	7760	15	in	in	IN
cord-015021-pol2qm74	7760	16	different	different	JJ
cord-015021-pol2qm74	7760	17	models	model	NNS
cord-015021-pol2qm74	7760	18	of	of	IN
cord-015021-pol2qm74	7760	19	haemorrhagie	haemorrhagie	NNP
cord-015021-pol2qm74	7760	20	and	and	CC
cord-015021-pol2qm74	7760	21	endotoxie	endotoxie	NNP
cord-015021-pol2qm74	7760	22	shock	shock	NN
cord-015021-pol2qm74	7760	23	.	.	.
cord-015021-pol2qm74	7761	1	The	the	DT
cord-015021-pol2qm74	7761	2	protective	protective	JJ
cord-015021-pol2qm74	7761	3	effect	effect	NN
cord-015021-pol2qm74	7761	4	of	of	IN
cord-015021-pol2qm74	7761	5	POF	POF	NNP
cord-015021-pol2qm74	7761	6	was	be	VBD
cord-015021-pol2qm74	7761	7	dose	dose	NN
cord-015021-pol2qm74	7761	8	-	-	HYPH
cord-015021-pol2qm74	7761	9	dependent	dependent	JJ
cord-015021-pol2qm74	7761	10	and	and	CC
cord-015021-pol2qm74	7761	11	observed	observe	VBD
cord-015021-pol2qm74	7761	12	even	even	RB
cord-015021-pol2qm74	7761	13	when	when	WRB
cord-015021-pol2qm74	7761	14	POF	POF	NNP
cord-015021-pol2qm74	7761	15	was	be	VBD
cord-015021-pol2qm74	7761	16	given	give	VBN
cord-015021-pol2qm74	7761	17	up	up	IN
cord-015021-pol2qm74	7761	18	to	to	TO
cord-015021-pol2qm74	7761	19	4	4	CD
cord-015021-pol2qm74	7761	20	hours	hour	NNS
cord-015021-pol2qm74	7761	21	after	after	IN
cord-015021-pol2qm74	7761	22	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7761	23	.	.	.
cord-015021-pol2qm74	7762	1	In	in	IN
cord-015021-pol2qm74	7762	2	order	order	NN
cord-015021-pol2qm74	7762	3	to	to	TO
cord-015021-pol2qm74	7762	4	evaluate	evaluate	VB
cord-015021-pol2qm74	7762	5	these	these	DT
cord-015021-pol2qm74	7762	6	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	7762	7	effects	effect	NNS
cord-015021-pol2qm74	7762	8	of	of	IN
cord-015021-pol2qm74	7762	9	POF	POF	NNP
cord-015021-pol2qm74	7762	10	in	in	IN
cord-015021-pol2qm74	7762	11	humans	human	NNS
cord-015021-pol2qm74	7762	12	,	,	,
cord-015021-pol2qm74	7762	13	we	-PRON-	PRP
cord-015021-pol2qm74	7762	14	studied	study	VBD
cord-015021-pol2qm74	7762	15	POF	POF	NNP
cord-015021-pol2qm74	7762	16	under	under	IN
cord-015021-pol2qm74	7762	17	controlled	control	VBN
cord-015021-pol2qm74	7762	18	conditions	condition	NNS
cord-015021-pol2qm74	7762	19	of	of	IN
cord-015021-pol2qm74	7762	20	endotoxlnemia	endotoxlnemia	NN
cord-015021-pol2qm74	7762	21	in	in	IN
cord-015021-pol2qm74	7762	22	volunteers	volunteer	NNS
cord-015021-pol2qm74	7762	23	.	.	.
cord-015021-pol2qm74	7763	1	We	-PRON-	PRP
cord-015021-pol2qm74	7763	2	found	find	VBD
cord-015021-pol2qm74	7763	3	that	that	IN
cord-015021-pol2qm74	7763	4	POF	POF	NNP
cord-015021-pol2qm74	7763	5	selectively	selectively	RB
cord-015021-pol2qm74	7763	6	inhibits	inhibit	VBZ
cord-015021-pol2qm74	7763	7	the	the	DT
cord-015021-pol2qm74	7763	8	LPS	LPS	NNP
cord-015021-pol2qm74	7763	9	-	-	HYPH
cord-015021-pol2qm74	7763	10	indueed	indueed	NN
cord-015021-pol2qm74	7763	11	endogenous	endogenous	JJ
cord-015021-pol2qm74	7763	12	formation	formation	NN
cord-015021-pol2qm74	7763	13	of	of	IN
cord-015021-pol2qm74	7763	14	TNF	TNF	NNP
cord-015021-pol2qm74	7763	15	without	without	IN
cord-015021-pol2qm74	7763	16	affecting	affect	VBG
cord-015021-pol2qm74	7763	17	IL-6	IL-6	NNP
cord-015021-pol2qm74	7763	18	and	and	CC
cord-015021-pol2qm74	7763	19	IL-8	IL-8	NNP
cord-015021-pol2qm74	7763	20	.	.	.
cord-015021-pol2qm74	7764	1	Moreover	moreover	RB
cord-015021-pol2qm74	7764	2	,	,	,
cord-015021-pol2qm74	7764	3	POF	POF	NNP
cord-015021-pol2qm74	7764	4	counteracts	counteract	VBZ
cord-015021-pol2qm74	7764	5	the	the	DT
cord-015021-pol2qm74	7764	6	LPS	LPS	NNP
cord-015021-pol2qm74	7764	7	-	-	HYPH
cord-015021-pol2qm74	7764	8	indueed	indueed	NNP
cord-015021-pol2qm74	7764	9	initial	initial	JJ
cord-015021-pol2qm74	7764	10	leukocytopenia	leukocytopenia	NNS
cord-015021-pol2qm74	7764	11	by	by	IN
cord-015021-pol2qm74	7764	12	interfering	interfere	VBG
cord-015021-pol2qm74	7764	13	with	with	IN
cord-015021-pol2qm74	7764	14	the	the	DT
cord-015021-pol2qm74	7764	15	adherence	adherence	NN
cord-015021-pol2qm74	7764	16	of	of	IN
cord-015021-pol2qm74	7764	17	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7764	18	in	in	IN
cord-015021-pol2qm74	7764	19	the	the	DT
cord-015021-pol2qm74	7764	20	microvasculature	microvasculature	NN
cord-015021-pol2qm74	7764	21	.	.	.
cord-015021-pol2qm74	7765	1	Meanwhile	meanwhile	RB
cord-015021-pol2qm74	7765	2	the	the	DT
cord-015021-pol2qm74	7765	3	inhibition	inhibition	NN
cord-015021-pol2qm74	7765	4	of	of	IN
cord-015021-pol2qm74	7765	5	endogenous	endogenous	JJ
cord-015021-pol2qm74	7765	6	formation	formation	NN
cord-015021-pol2qm74	7765	7	of	of	IN
cord-015021-pol2qm74	7765	8	TNF	TNF	NNP
cord-015021-pol2qm74	7765	9	by	by	IN
cord-015021-pol2qm74	7765	10	POF	POF	NNP
cord-015021-pol2qm74	7765	11	could	could	MD
cord-015021-pol2qm74	7765	12	be	be	VB
cord-015021-pol2qm74	7765	13	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7765	14	under	under	IN
cord-015021-pol2qm74	7765	15	different	different	JJ
cord-015021-pol2qm74	7765	16	clinical	clinical	JJ
cord-015021-pol2qm74	7765	17	conditions	condition	NNS
cord-015021-pol2qm74	7765	18	of	of	IN
cord-015021-pol2qm74	7765	19	acute	acute	JJ
cord-015021-pol2qm74	7765	20	and	and	CC
cord-015021-pol2qm74	7765	21	chronic	chronic	JJ
cord-015021-pol2qm74	7765	22	cytokine	cytokine	NN
cord-015021-pol2qm74	7765	23	release	release	NN
cord-015021-pol2qm74	7765	24	syndromes	syndrome	NNS
cord-015021-pol2qm74	7765	25	,	,	,
cord-015021-pol2qm74	7765	26	{	{	-LRB-
cord-015021-pol2qm74	7765	27	OKT3	OKT3	NNP
cord-015021-pol2qm74	7765	28	first	first	JJ
cord-015021-pol2qm74	7765	29	-	-	HYPH
cord-015021-pol2qm74	7765	30	dose	dose	NN
cord-015021-pol2qm74	7765	31	reaction	reaction	NN
cord-015021-pol2qm74	7765	32	,	,	,
cord-015021-pol2qm74	7765	33	cancer	cancer	NN
cord-015021-pol2qm74	7765	34	-	-	HYPH
cord-015021-pol2qm74	7765	35	or	or	CC
cord-015021-pol2qm74	7765	36	tuberculosis	tuberculosis	NN
cord-015021-pol2qm74	7765	37	-	-	HYPH
cord-015021-pol2qm74	7765	38	induced	induce	VBN
cord-015021-pol2qm74	7765	39	cachexla	cachexla	NN
cord-015021-pol2qm74	7765	40	}	}	-RRB-
cord-015021-pol2qm74	7765	41	.	.	.
cord-015021-pol2qm74	7766	1	It	-PRON-	PRP
cord-015021-pol2qm74	7766	2	appears	appear	VBZ
cord-015021-pol2qm74	7766	3	worthwile	worthwile	JJ
cord-015021-pol2qm74	7766	4	and	and	CC
cord-015021-pol2qm74	7766	5	promising	promise	VBG
cord-015021-pol2qm74	7766	6	to	to	TO
cord-015021-pol2qm74	7766	7	investigate	investigate	VB
cord-015021-pol2qm74	7766	8	wether	wether	WP
cord-015021-pol2qm74	7766	9	POF	POF	NNP
cord-015021-pol2qm74	7766	10	exhibits	exhibit	VBZ
cord-015021-pol2qm74	7766	11	beneficial	beneficial	JJ
cord-015021-pol2qm74	7766	12	effects	effect	NNS
cord-015021-pol2qm74	7766	13	also	also	RB
cord-015021-pol2qm74	7766	14	in	in	IN
cord-015021-pol2qm74	7766	15	septic	septic	JJ
cord-015021-pol2qm74	7766	16	patients	patient	NNS
cord-015021-pol2qm74	7766	17	.	.	.
cord-015021-pol2qm74	7767	1	Objectives	objective	NNS
cord-015021-pol2qm74	7767	2	:	:	:
cord-015021-pol2qm74	7767	3	To	to	TO
cord-015021-pol2qm74	7767	4	determine	determine	VB
cord-015021-pol2qm74	7767	5	the	the	DT
cord-015021-pol2qm74	7767	6	specific	specific	JJ
cord-015021-pol2qm74	7767	7	role	role	NN
cord-015021-pol2qm74	7767	8	of	of	IN
cord-015021-pol2qm74	7767	9	PAF	PAF	NNP
cord-015021-pol2qm74	7767	10	in	in	IN
cord-015021-pol2qm74	7767	11	both	both	CC
cord-015021-pol2qm74	7767	12	lethal	lethal	JJ
cord-015021-pol2qm74	7767	13	primate	primate	NN
cord-015021-pol2qm74	7767	14	bacteremia	bacteremia	NN
cord-015021-pol2qm74	7767	15	and	and	CC
cord-015021-pol2qm74	7767	16	nonlethal	nonlethal	JJ
cord-015021-pol2qm74	7767	17	human	human	JJ
cord-015021-pol2qm74	7767	18	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7767	19	.	.	.
cord-015021-pol2qm74	7768	1	Materials	material	NNS
cord-015021-pol2qm74	7768	2	and	and	CC
cord-015021-pol2qm74	7768	3	methods	method	NNS
cord-015021-pol2qm74	7768	4	:	:	:
cord-015021-pol2qm74	7768	5	Two	two	CD
cord-015021-pol2qm74	7768	6	double	double	JJ
cord-015021-pol2qm74	7768	7	-	-	HYPH
cord-015021-pol2qm74	7768	8	blinded	blinded	JJ
cord-015021-pol2qm74	7768	9	placebo	placebo	NN
cord-015021-pol2qm74	7768	10	controlled	control	VBN
cord-015021-pol2qm74	7768	11	studies	study	NNS
cord-015021-pol2qm74	7768	12	were	be	VBD
cord-015021-pol2qm74	7768	13	performed	perform	VBN
cord-015021-pol2qm74	7768	14	.	.	.
cord-015021-pol2qm74	7769	1	First	first	RB
cord-015021-pol2qm74	7769	2	,	,	,
cord-015021-pol2qm74	7769	3	ten	ten	CD
cord-015021-pol2qm74	7769	4	baboons	baboon	NNS
cord-015021-pol2qm74	7769	5	(	(	-LRB-
cord-015021-pol2qm74	7769	6	14.5	14.5	CD
cord-015021-pol2qm74	7769	7	+	+	CC
cord-015021-pol2qm74	7769	8	.7	.7	NN
cord-015021-pol2qm74	7769	9	kg	kg	NNP
cord-015021-pol2qm74	7769	10	)	)	-RRB-
cord-015021-pol2qm74	7769	11	,	,	,
cord-015021-pol2qm74	7769	12	were	be	VBD
cord-015021-pol2qm74	7769	13	randomized	randomize	VBN
cord-015021-pol2qm74	7769	14	to	to	IN
cord-015021-pol2qm74	7769	15	a	a	DT
cord-015021-pol2qm74	7769	16	control	control	NN
cord-015021-pol2qm74	7769	17	group	group	NN
cord-015021-pol2qm74	7769	18	receiving	receive	VBG
cord-015021-pol2qm74	7769	19	101	101	CD
cord-015021-pol2qm74	7769	20	°	°	NNP
cord-015021-pol2qm74	7769	21	cfu	cfu	NN
cord-015021-pol2qm74	7769	22	/	/	SYM
cord-015021-pol2qm74	7769	23	kg	kg	NNS
cord-015021-pol2qm74	7769	24	of	of	IN
cord-015021-pol2qm74	7769	25	intravenously	intravenously	RB
cord-015021-pol2qm74	7769	26	administered	administer	VBN
cord-015021-pol2qm74	7769	27	E.	E.	NNP
cord-015021-pol2qm74	7769	28	co	co	NNP
cord-015021-pol2qm74	7769	29	/	/	SYM
cord-015021-pol2qm74	7769	30	i	i	PRP
cord-015021-pol2qm74	7769	31	(	(	-LRB-
cord-015021-pol2qm74	7769	32	n=5	n=5	NNP
cord-015021-pol2qm74	7769	33	)	)	-RRB-
cord-015021-pol2qm74	7769	34	and	and	CC
cord-015021-pol2qm74	7769	35	a	a	DT
cord-015021-pol2qm74	7769	36	treatment	treatment	NN
cord-015021-pol2qm74	7769	37	group	group	NN
cord-015021-pol2qm74	7769	38	(	(	-LRB-
cord-015021-pol2qm74	7769	39	n	n	NN
cord-015021-pol2qm74	7769	40	=	=	SYM
cord-015021-pol2qm74	7769	41	5	5	CD
cord-015021-pol2qm74	7769	42	)	)	-RRB-
cord-015021-pol2qm74	7769	43	,	,	,
cord-015021-pol2qm74	7769	44	pretreated	pretreate	VBN
cord-015021-pol2qm74	7769	45	with	with	IN
cord-015021-pol2qm74	7769	46	.1	.1	.
cord-015021-pol2qm74	7770	1	mg	mg	NNP
cord-015021-pol2qm74	7770	2	/	/	SYM
cord-015021-pol2qm74	7770	3	kg	kg	NNP
cord-015021-pol2qm74	7770	4	of	of	IN
cord-015021-pol2qm74	7770	5	PAF	PAF	NNP
cord-015021-pol2qm74	7770	6	receptor	receptor	NN
cord-015021-pol2qm74	7770	7	antagonist	antagonist	NN
cord-015021-pol2qm74	7771	1	Ro24	Ro24	NNP
cord-015021-pol2qm74	7771	2	-	-	CD
cord-015021-pol2qm74	7771	3	4736	4736	CD
cord-015021-pol2qm74	7771	4	two	two	CD
cord-015021-pol2qm74	7771	5	hours	hour	NNS
cord-015021-pol2qm74	7771	6	prior	prior	RB
cord-015021-pol2qm74	7771	7	to	to	IN
cord-015021-pol2qm74	7771	8	E.	E.	NNP
cord-015021-pol2qm74	7771	9	co	co	NNP
cord-015021-pol2qm74	7771	10	/	/	SYM
cord-015021-pol2qm74	7771	11	i	i	PRP
cord-015021-pol2qm74	7771	12	infusion	infusion	NN
cord-015021-pol2qm74	7771	13	.	.	.
cord-015021-pol2qm74	7772	1	In	in	IN
cord-015021-pol2qm74	7772	2	a	a	DT
cord-015021-pol2qm74	7772	3	second	second	JJ
cord-015021-pol2qm74	7772	4	study	study	NN
cord-015021-pol2qm74	7772	5	,	,	,
cord-015021-pol2qm74	7772	6	ten	ten	CD
cord-015021-pol2qm74	7772	7	healthy	healthy	JJ
cord-015021-pol2qm74	7772	8	male	male	JJ
cord-015021-pol2qm74	7772	9	volunteers	volunteer	NNS
cord-015021-pol2qm74	7772	10	were	be	VBD
cord-015021-pol2qm74	7772	11	randomized	randomize	VBN
cord-015021-pol2qm74	7772	12	to	to	IN
cord-015021-pol2qm74	7772	13	a	a	DT
cord-015021-pol2qm74	7772	14	control	control	NN
cord-015021-pol2qm74	7772	15	group	group	NN
cord-015021-pol2qm74	7772	16	receiving	receive	VBG
cord-015021-pol2qm74	7772	17	4	4	CD
cord-015021-pol2qm74	7772	18	ng	ng	NNP
cord-015021-pol2qm74	7772	19	/	/	SYM
cord-015021-pol2qm74	7772	20	kg	kg	NNS
cord-015021-pol2qm74	7772	21	of	of	IN
cord-015021-pol2qm74	7772	22	intravenously	intravenously	RB
cord-015021-pol2qm74	7772	23	administered	administer	VBN
cord-015021-pol2qm74	7772	24	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7772	25	(	(	-LRB-
cord-015021-pol2qm74	7772	26	LPS	LPS	NNP
cord-015021-pol2qm74	7772	27	)	)	-RRB-
cord-015021-pol2qm74	7772	28	(	(	-LRB-
cord-015021-pol2qm74	7772	29	n=5	n=5	NNP
cord-015021-pol2qm74	7772	30	)	)	-RRB-
cord-015021-pol2qm74	7772	31	and	and	CC
cord-015021-pol2qm74	7772	32	a	a	DT
cord-015021-pol2qm74	7772	33	treatment	treatment	NN
cord-015021-pol2qm74	7772	34	group	group	NN
cord-015021-pol2qm74	7772	35	(	(	-LRB-
cord-015021-pol2qm74	7772	36	n=5	n=5	NNP
cord-015021-pol2qm74	7772	37	)	)	-RRB-
cord-015021-pol2qm74	7772	38	pretreated	pretreate	VBN
cord-015021-pol2qm74	7772	39	with	with	IN
cord-015021-pol2qm74	7772	40	10	10	CD
cord-015021-pol2qm74	7772	41	mg	mg	NN
cord-015021-pol2qm74	7772	42	of	of	IN
cord-015021-pol2qm74	7772	43	Ro24	Ro24	NNP
cord-015021-pol2qm74	7772	44	-	-	HYPH
cord-015021-pol2qm74	7772	45	4736	4736	CD
cord-015021-pol2qm74	7772	46	eighteen	eighteen	CD
cord-015021-pol2qm74	7772	47	hours	hour	NNS
cord-015021-pol2qm74	7772	48	prior	prior	RB
cord-015021-pol2qm74	7772	49	to	to	IN
cord-015021-pol2qm74	7772	50	LPS	LPS	NNP
cord-015021-pol2qm74	7772	51	administration	administration	NN
cord-015021-pol2qm74	7772	52	.	.	.
cord-015021-pol2qm74	7773	1	Physiologic	physiologic	JJ
cord-015021-pol2qm74	7773	2	parameters	parameter	NNS
cord-015021-pol2qm74	7773	3	and	and	CC
cord-015021-pol2qm74	7773	4	cytokine	cytokine	NN
cord-015021-pol2qm74	7773	5	levels	level	NNS
cord-015021-pol2qm74	7773	6	were	be	VBD
cord-015021-pol2qm74	7773	7	measured	measure	VBN
cord-015021-pol2qm74	7773	8	continuously	continuously	RB
cord-015021-pol2qm74	7773	9	in	in	IN
cord-015021-pol2qm74	7773	10	both	both	DT
cord-015021-pol2qm74	7773	11	studies	study	NNS
cord-015021-pol2qm74	7773	12	for	for	IN
cord-015021-pol2qm74	7773	13	24	24	CD
cord-015021-pol2qm74	7773	14	hours	hour	NNS
cord-015021-pol2qm74	7773	15	.	.	.
cord-015021-pol2qm74	7774	1	Results	result	NNS
cord-015021-pol2qm74	7774	2	:	:	:
cord-015021-pol2qm74	7775	1	Baboons	baboon	NNS
cord-015021-pol2qm74	7775	2	pretreated	pretreate	VBD
cord-015021-pol2qm74	7775	3	with	with	IN
cord-015021-pol2qm74	7775	4	the	the	DT
cord-015021-pol2qm74	7775	5	PAF	PAF	NNP
cord-015021-pol2qm74	7775	6	antagonist	antagonist	NN
cord-015021-pol2qm74	7775	7	had	have	VBD
cord-015021-pol2qm74	7775	8	improved	improve	VBN
cord-015021-pol2qm74	7775	9	oxygenation	oxygenation	NN
cord-015021-pol2qm74	7775	10	(	(	-LRB-
cord-015021-pol2qm74	7775	11	96	96	CD
cord-015021-pol2qm74	7775	12	+	+	SYM
cord-015021-pol2qm74	7775	13	11	11	CD
cord-015021-pol2qm74	7775	14	mm	mm	NN
cord-015021-pol2qm74	7776	1	Hg	Hg	NNP
cord-015021-pol2qm74	7776	2	v	v	NN
cord-015021-pol2qm74	7776	3	59	59	CD
cord-015021-pol2qm74	7776	4	-+	-+	NNP
cord-015021-pol2qm74	7776	5	6	6	CD
cord-015021-pol2qm74	7776	6	in	in	IN
cord-015021-pol2qm74	7776	7	controls	control	NNS
cord-015021-pol2qm74	7776	8	,	,	,
cord-015021-pol2qm74	7776	9	p	p	NN
cord-015021-pol2qm74	7776	10	<	<	XX
cord-015021-pol2qm74	7776	11	0.05	0.05	CD
cord-015021-pol2qm74	7776	12	)	)	-RRB-
cord-015021-pol2qm74	7776	13	and	and	CC
cord-015021-pol2qm74	7776	14	creatinine	creatinine	NN
cord-015021-pol2qm74	7776	15	clearance	clearance	NN
cord-015021-pol2qm74	7777	1	12	12	CD
cord-015021-pol2qm74	7777	2	hours	hour	NNS
cord-015021-pol2qm74	7777	3	post	post	NN
cord-015021-pol2qm74	7777	4	E.coli	E.coli	NNS
cord-015021-pol2qm74	7777	5	(	(	-LRB-
cord-015021-pol2qm74	7778	1	39.8	39.8	CD
cord-015021-pol2qm74	7778	2	+	+	SYM
cord-015021-pol2qm74	7778	3	23.4	23.4	CD
cord-015021-pol2qm74	7778	4	ml	ml	NNS
cord-015021-pol2qm74	7778	5	/	/	SYM
cord-015021-pol2qm74	7778	6	min	min	NN
cord-015021-pol2qm74	7778	7	v	v	NN
cord-015021-pol2qm74	7778	8	0.1	0.1	CD
cord-015021-pol2qm74	7778	9	_	_	NN
cord-015021-pol2qm74	7778	10	+	+	SYM
cord-015021-pol2qm74	7778	11	0.1	0.1	CD
cord-015021-pol2qm74	7778	12	in	in	IN
cord-015021-pol2qm74	7778	13	controls	control	NNS
cord-015021-pol2qm74	7778	14	,	,	,
cord-015021-pol2qm74	7778	15	p	p	NN
cord-015021-pol2qm74	7778	16	<	<	XX
cord-015021-pol2qm74	7778	17	0.05	0.05	CD
cord-015021-pol2qm74	7778	18	)	)	-RRB-
cord-015021-pol2qm74	7778	19	.	.	.
cord-015021-pol2qm74	7779	1	Similarly	similarly	RB
cord-015021-pol2qm74	7779	2	,	,	,
cord-015021-pol2qm74	7779	3	volunteers	volunteer	NNS
cord-015021-pol2qm74	7779	4	pretreated	pretreate	VBD
cord-015021-pol2qm74	7779	5	with	with	IN
cord-015021-pol2qm74	7779	6	the	the	DT
cord-015021-pol2qm74	7779	7	PAF	PAF	NNP
cord-015021-pol2qm74	7779	8	antagonist	antagonist	NN
cord-015021-pol2qm74	7779	9	experienced	experience	VBD
cord-015021-pol2qm74	7779	10	fewer	few	JJR
cord-015021-pol2qm74	7779	11	symptoms	symptom	NNS
cord-015021-pol2qm74	7779	12	,	,	,
cord-015021-pol2qm74	7779	13	including	include	VBG
cord-015021-pol2qm74	7779	14	rigors	rigor	NNS
cord-015021-pol2qm74	7779	15	and	and	CC
cord-015021-pol2qm74	7779	16	myalgias	myalgia	NNS
cord-015021-pol2qm74	7779	17	at	at	IN
cord-015021-pol2qm74	7779	18	1	1	CD
cord-015021-pol2qm74	7779	19	hour	hour	NN
cord-015021-pol2qm74	7779	20	post	post	NN
cord-015021-pol2qm74	7779	21	LPS	lp	NNS
cord-015021-pol2qm74	7779	22	.	.	.
cord-015021-pol2qm74	7780	1	This	this	DT
cord-015021-pol2qm74	7780	2	was	be	VBD
cord-015021-pol2qm74	7780	3	in	in	IN
cord-015021-pol2qm74	7780	4	concert	concert	NN
cord-015021-pol2qm74	7780	5	with	with	IN
cord-015021-pol2qm74	7780	6	a	a	DT
cord-015021-pol2qm74	7780	7	diminished	diminished	JJ
cord-015021-pol2qm74	7780	8	peak	peak	NN
cord-015021-pol2qm74	7780	9	cortisol	cortisol	NN
cord-015021-pol2qm74	7780	10	(	(	-LRB-
cord-015021-pol2qm74	7780	11	668	668	CD
cord-015021-pol2qm74	7780	12	+	+	CC
cord-015021-pol2qm74	7780	13	_	_	NN
cord-015021-pol2qm74	7780	14	107	107	CD
cord-015021-pol2qm74	7780	15	mmot	mmot	NNP
cord-015021-pol2qm74	7780	16	/	/	SYM
cord-015021-pol2qm74	7780	17	L	l	NN
cord-015021-pol2qm74	7780	18	v	v	NN
cord-015021-pol2qm74	7780	19	959	959	CD
cord-015021-pol2qm74	7781	1	+	+	CC
cord-015021-pol2qm74	7782	1	-159	-159	NNP
cord-015021-pol2qm74	7782	2	mmol	mmol	NNP
cord-015021-pol2qm74	7782	3	/	/	SYM
cord-015021-pol2qm74	7782	4	L	L	NNP
cord-015021-pol2qm74	7782	5	in	in	IN
cord-015021-pol2qm74	7782	6	controls	control	NNS
cord-015021-pol2qm74	7782	7	,	,	,
cord-015021-pol2qm74	7782	8	p	p	NN
cord-015021-pol2qm74	7782	9	<	<	XX
cord-015021-pol2qm74	7782	10	0.05	0.05	CD
cord-015021-pol2qm74	7782	11	)	)	-RRB-
cord-015021-pol2qm74	7782	12	,	,	,
cord-015021-pol2qm74	7782	13	epinephrine	epinephrine	NN
cord-015021-pol2qm74	7782	14	secretion	secretion	NN
cord-015021-pol2qm74	7782	15	(	(	-LRB-
cord-015021-pol2qm74	7782	16	1057	1057	CD
cord-015021-pol2qm74	7782	17	+	+	CC
cord-015021-pol2qm74	7783	1	165	165	CD
cord-015021-pol2qm74	7783	2	nmol	nmol	NNP
cord-015021-pol2qm74	7783	3	/	/	SYM
cord-015021-pol2qm74	7783	4	L	l	NN
cord-015021-pol2qm74	7783	5	v	v	NNP
cord-015021-pol2qm74	7783	6	2029	2029	CD
cord-015021-pol2qm74	7783	7	+	+	SYM
cord-015021-pol2qm74	7783	8	431	431	CD
cord-015021-pol2qm74	7783	9	nmol	nmol	NNP
cord-015021-pol2qm74	7783	10	/	/	SYM
cord-015021-pol2qm74	7783	11	L	l	NN
cord-015021-pol2qm74	7783	12	in	in	IN
cord-015021-pol2qm74	7783	13	controls	control	NNS
cord-015021-pol2qm74	7783	14	,	,	,
cord-015021-pol2qm74	7783	15	p	p	NN
cord-015021-pol2qm74	7783	16	<	<	XX
cord-015021-pol2qm74	7783	17	0.05	0.05	CD
cord-015021-pol2qm74	7783	18	)	)	-RRB-
cord-015021-pol2qm74	7783	19	.	.	.
cord-015021-pol2qm74	7784	1	Hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	7784	2	and	and	CC
cord-015021-pol2qm74	7784	3	circulating	circulate	VBG
cord-015021-pol2qm74	7784	4	TNFa	TNFa	NNP
cord-015021-pol2qm74	7784	5	levels	level	NNS
cord-015021-pol2qm74	7784	6	(	(	-LRB-
cord-015021-pol2qm74	7784	7	data	datum	NNS
cord-015021-pol2qm74	7784	8	not	not	RB
cord-015021-pol2qm74	7784	9	shown	show	VBN
cord-015021-pol2qm74	7784	10	)	)	-RRB-
cord-015021-pol2qm74	7784	11	were	be	VBD
cord-015021-pol2qm74	7784	12	unaffected	unaffected	JJ
cord-015021-pol2qm74	7784	13	in	in	IN
cord-015021-pol2qm74	7784	14	either	either	DT
cord-015021-pol2qm74	7784	15	study	study	NN
cord-015021-pol2qm74	7784	16	by	by	IN
cord-015021-pol2qm74	7784	17	prior	prior	JJ
cord-015021-pol2qm74	7784	18	PAF	PAF	NNP
cord-015021-pol2qm74	7784	19	antagonism	antagonism	NN
cord-015021-pol2qm74	7784	20	.	.	.
cord-015021-pol2qm74	7785	1	Concluslons	concluslon	NNS
cord-015021-pol2qm74	7785	2	:	:	:
cord-015021-pol2qm74	7786	1	PAF	PAF	NNP
cord-015021-pol2qm74	7786	2	influences	influence	VBZ
cord-015021-pol2qm74	7786	3	some	some	DT
cord-015021-pol2qm74	7786	4	components	component	NNS
cord-015021-pol2qm74	7786	5	of	of	IN
cord-015021-pol2qm74	7786	6	the	the	DT
cord-015021-pol2qm74	7786	7	multi	multi	JJ
cord-015021-pol2qm74	7786	8	-	-	JJ
cord-015021-pol2qm74	7786	9	organ	organ	JJ
cord-015021-pol2qm74	7786	10	failure	failure	NN
cord-015021-pol2qm74	7786	11	syndrome	syndrome	NN
cord-015021-pol2qm74	7786	12	in	in	IN
cord-015021-pol2qm74	7786	13	lethal	lethal	JJ
cord-015021-pol2qm74	7786	14	gram	gram	NN
cord-015021-pol2qm74	7786	15	negative	negative	JJ
cord-015021-pol2qm74	7786	16	sepsis	sepsis	NN
cord-015021-pol2qm74	7786	17	and	and	CC
cord-015021-pol2qm74	7786	18	the	the	DT
cord-015021-pol2qm74	7786	19	counter	counter	JJ
cord-015021-pol2qm74	7786	20	-	-	JJ
cord-015021-pol2qm74	7786	21	regulatory	regulatory	JJ
cord-015021-pol2qm74	7786	22	hormonal	hormonal	JJ
cord-015021-pol2qm74	7786	23	system	system	NN
cord-015021-pol2qm74	7786	24	in	in	IN
cord-015021-pol2qm74	7786	25	human	human	JJ
cord-015021-pol2qm74	7786	26	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7786	27	through	through	IN
cord-015021-pol2qm74	7786	28	TNF	TNF	NNP
cord-015021-pol2qm74	7786	29	-	-	HYPH
cord-015021-pol2qm74	7786	30	independent	independent	JJ
cord-015021-pol2qm74	7786	31	mechanisms	mechanism	NNS
cord-015021-pol2qm74	7786	32	.	.	.
cord-015021-pol2qm74	7787	1	PAF	PAF	NNP
cord-015021-pol2qm74	7787	2	antagonists	antagonist	NNS
cord-015021-pol2qm74	7787	3	may	may	MD
cord-015021-pol2qm74	7787	4	serve	serve	VB
cord-015021-pol2qm74	7787	5	as	as	IN
cord-015021-pol2qm74	7787	6	adjuncts	adjunct	NNS
cord-015021-pol2qm74	7787	7	to	to	IN
cord-015021-pol2qm74	7787	8	cytokine	cytokine	NN
cord-015021-pol2qm74	7787	9	blockade	blockade	NN
cord-015021-pol2qm74	7787	10	in	in	IN
cord-015021-pol2qm74	7787	11	the	the	DT
cord-015021-pol2qm74	7787	12	treatment	treatment	NN
cord-015021-pol2qm74	7787	13	of	of	IN
cord-015021-pol2qm74	7787	14	gram	gram	NN
cord-015021-pol2qm74	7787	15	negative	negative	JJ
cord-015021-pol2qm74	7787	16	sepsis	sepsis	NN
cord-015021-pol2qm74	7787	17	.	.	.
cord-015021-pol2qm74	7788	1	The	the	DT
cord-015021-pol2qm74	7788	2	mediator	mediator	NN
cord-015021-pol2qm74	7788	3	Role	role	NN
cord-015021-pol2qm74	7788	4	of	of	IN
cord-015021-pol2qm74	7788	5	Platelet	platelet	NN
cord-015021-pol2qm74	7788	6	-	-	HYPH
cord-015021-pol2qm74	7788	7	Activating	activate	VBG
cord-015021-pol2qm74	7788	8	Factor	factor	NN
cord-015021-pol2qm74	7788	9	in	in	IN
cord-015021-pol2qm74	7788	10	Gramnegative	Gramnegative	NNP
cord-015021-pol2qm74	7788	11	Septic	Septic	NNP
cord-015021-pol2qm74	7788	12	Shock	Shock	NNP
cord-015021-pol2qm74	7788	13	Pierre	Pierre	NNP
cord-015021-pol2qm74	7788	14	G.	G.	NNP
cord-015021-pol2qm74	7788	15	Braquet	Braquet	NNP
cord-015021-pol2qm74	7788	16	,	,	,
cord-015021-pol2qm74	7788	17	David	David	NNP
cord-015021-pol2qm74	7788	18	Hosford	Hosford	NNP
cord-015021-pol2qm74	7788	19	and	and	CC
cord-015021-pol2qm74	7788	20	Matyas	Matyas	NNP
cord-015021-pol2qm74	7788	21	Koltai	Koltai	NNP
cord-015021-pol2qm74	7789	1	Institut	Institut	NNP
cord-015021-pol2qm74	7789	2	Henri	Henri	NNP
cord-015021-pol2qm74	7789	3	Beaufour	Beaufour	NNP
cord-015021-pol2qm74	7789	4	,	,	,
cord-015021-pol2qm74	7789	5	Le	Le	NNP
cord-015021-pol2qm74	7789	6	Plessis	Plessis	NNP
cord-015021-pol2qm74	7789	7	Robinson	Robinson	NNP
cord-015021-pol2qm74	7789	8	,	,	,
cord-015021-pol2qm74	7789	9	France	France	NNP
cord-015021-pol2qm74	7789	10	Considerable	considerable	JJ
cord-015021-pol2qm74	7789	11	evidence	evidence	NN
cord-015021-pol2qm74	7789	12	has	have	VBZ
cord-015021-pol2qm74	7789	13	been	be	VBN
cord-015021-pol2qm74	7789	14	accumulated	accumulate	VBN
cord-015021-pol2qm74	7789	15	to	to	TO
cord-015021-pol2qm74	7789	16	support	support	VB
cord-015021-pol2qm74	7789	17	the	the	DT
cord-015021-pol2qm74	7789	18	concept	concept	NN
cord-015021-pol2qm74	7789	19	that	that	IN
cord-015021-pol2qm74	7789	20	a	a	DT
cord-015021-pol2qm74	7789	21	PAF	PAF	NNP
cord-015021-pol2qm74	7789	22	/	/	SYM
cord-015021-pol2qm74	7789	23	cytokine	cytokine	JJ
cord-015021-pol2qm74	7789	24	autogenerated	autogenerated	JJ
cord-015021-pol2qm74	7789	25	feedback	feedback	NN
cord-015021-pol2qm74	7789	26	network	network	NN
cord-015021-pol2qm74	7789	27	is	be	VBZ
cord-015021-pol2qm74	7789	28	responsible	responsible	JJ
cord-015021-pol2qm74	7789	29	for	for	IN
cord-015021-pol2qm74	7789	30	priming	priming	NN
cord-015021-pol2qm74	7789	31	and	and	CC
cord-015021-pol2qm74	7789	32	amplification	amplification	NN
cord-015021-pol2qm74	7789	33	of	of	IN
cord-015021-pol2qm74	7789	34	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7789	35	mediator	mediator	NN
cord-015021-pol2qm74	7789	36	release	release	NN
cord-015021-pol2qm74	7789	37	in	in	IN
cord-015021-pol2qm74	7789	38	septic	septic	JJ
cord-015021-pol2qm74	7789	39	shock	shock	NN
cord-015021-pol2qm74	7789	40	.	.	.
cord-015021-pol2qm74	7790	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	7790	2	,	,	,
cord-015021-pol2qm74	7790	3	such	such	JJ
cord-015021-pol2qm74	7790	4	as	as	IN
cord-015021-pol2qm74	7790	5	TNF~	tnf~	CD
cord-015021-pol2qm74	7791	1	x	x	LS
cord-015021-pol2qm74	7791	2	,	,	,
cord-015021-pol2qm74	7791	3	IL-1	IL-1	NNP
cord-015021-pol2qm74	7791	4	and	and	CC
cord-015021-pol2qm74	7791	5	other	other	JJ
cord-015021-pol2qm74	7791	6	interleukins	interleukin	NNS
cord-015021-pol2qm74	7791	7	interact	interact	VBP
cord-015021-pol2qm74	7791	8	with	with	IN
cord-015021-pol2qm74	7791	9	PAF	PAF	NNP
cord-015021-pol2qm74	7791	10	which	which	WDT
cord-015021-pol2qm74	7791	11	then	then	RB
cord-015021-pol2qm74	7791	12	amplifies	amplify	VBZ
cord-015021-pol2qm74	7791	13	cytokine	cytokine	JJ
cord-015021-pol2qm74	7791	14	production	production	NN
cord-015021-pol2qm74	7791	15	,	,	,
cord-015021-pol2qm74	7791	16	therefore	therefore	RB
cord-015021-pol2qm74	7791	17	,	,	,
cord-015021-pol2qm74	7791	18	PAF	PAF	NNP
cord-015021-pol2qm74	7791	19	may	may	MD
cord-015021-pol2qm74	7791	20	be	be	VB
cord-015021-pol2qm74	7791	21	the	the	DT
cord-015021-pol2qm74	7791	22	principle	principle	JJ
cord-015021-pol2qm74	7791	23	mediator	mediator	NN
cord-015021-pol2qm74	7791	24	in	in	IN
cord-015021-pol2qm74	7791	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7791	26	shock	shock	NN
cord-015021-pol2qm74	7791	27	.	.	.
cord-015021-pol2qm74	7792	1	A	a	DT
cord-015021-pol2qm74	7792	2	single	single	JJ
cord-015021-pol2qm74	7792	3	factor	factor	NN
cord-015021-pol2qm74	7792	4	identified	identify	VBN
cord-015021-pol2qm74	7792	5	as	as	IN
cord-015021-pol2qm74	7792	6	TNF	TNF	NNP
cord-015021-pol2qm74	7792	7	is	be	VBZ
cord-015021-pol2qm74	7792	8	suggested	suggest	VBN
cord-015021-pol2qm74	7792	9	to	to	TO
cord-015021-pol2qm74	7792	10	play	play	VB
cord-015021-pol2qm74	7792	11	a	a	DT
cord-015021-pol2qm74	7792	12	pivotal	pivotal	JJ
cord-015021-pol2qm74	7792	13	role	role	NN
cord-015021-pol2qm74	7792	14	in	in	IN
cord-015021-pol2qm74	7792	15	the	the	DT
cord-015021-pol2qm74	7792	16	fatal	fatal	JJ
cord-015021-pol2qm74	7792	17	phase	phase	NN
cord-015021-pol2qm74	7792	18	of	of	IN
cord-015021-pol2qm74	7792	19	septic	septic	JJ
cord-015021-pol2qm74	7792	20	shock	shock	NN
cord-015021-pol2qm74	7792	21	.	.	.
cord-015021-pol2qm74	7793	1	Presumably	presumably	RB
cord-015021-pol2qm74	7793	2	excess	excess	JJ
cord-015021-pol2qm74	7793	3	TNF	TNF	NNP
cord-015021-pol2qm74	7793	4	release	release	NN
cord-015021-pol2qm74	7793	5	is	be	VBZ
cord-015021-pol2qm74	7793	6	the	the	DT
cord-015021-pol2qm74	7793	7	result	result	NN
cord-015021-pol2qm74	7793	8	of	of	IN
cord-015021-pol2qm74	7793	9	amplification	amplification	NN
cord-015021-pol2qm74	7793	10	process	process	NN
cord-015021-pol2qm74	7793	11	primarily	primarily	RB
cord-015021-pol2qm74	7793	12	triggered	trigger	VBN
cord-015021-pol2qm74	7793	13	by	by	IN
cord-015021-pol2qm74	7793	14	PAF	PAF	NNP
cord-015021-pol2qm74	7793	15	.	.	.
cord-015021-pol2qm74	7794	1	One	one	CD
cord-015021-pol2qm74	7794	2	may	may	MD
cord-015021-pol2qm74	7794	3	assume	assume	VB
cord-015021-pol2qm74	7794	4	that	that	IN
cord-015021-pol2qm74	7794	5	the	the	DT
cord-015021-pol2qm74	7794	6	high	high	JJ
cord-015021-pol2qm74	7794	7	TNF	TNF	NNP
cord-015021-pol2qm74	7794	8	concentration	concentration	NN
cord-015021-pol2qm74	7794	9	in	in	IN
cord-015021-pol2qm74	7794	10	the	the	DT
cord-015021-pol2qm74	7794	11	blood	blood	NN
cord-015021-pol2qm74	7794	12	of	of	IN
cord-015021-pol2qm74	7794	13	'	'	``
cord-015021-pol2qm74	7794	14	non	non	JJ
cord-015021-pol2qm74	7794	15	survivors	survivor	NNS
cord-015021-pol2qm74	7794	16	'	'	POS
cord-015021-pol2qm74	7794	17	is	be	VBZ
cord-015021-pol2qm74	7794	18	the	the	DT
cord-015021-pol2qm74	7794	19	consequence	consequence	NN
cord-015021-pol2qm74	7794	20	rather	rather	RB
cord-015021-pol2qm74	7794	21	than	than	IN
cord-015021-pol2qm74	7794	22	the	the	DT
cord-015021-pol2qm74	7794	23	cause	cause	NN
cord-015021-pol2qm74	7794	24	of	of	IN
cord-015021-pol2qm74	7794	25	cell	cell	NN
cord-015021-pol2qm74	7794	26	death	death	NN
cord-015021-pol2qm74	7794	27	.	.	.
cord-015021-pol2qm74	7795	1	The	the	DT
cord-015021-pol2qm74	7795	2	dubious	dubious	JJ
cord-015021-pol2qm74	7795	3	results	result	NNS
cord-015021-pol2qm74	7795	4	of	of	IN
cord-015021-pol2qm74	7795	5	clinical	clinical	JJ
cord-015021-pol2qm74	7795	6	trials	trial	NNS
cord-015021-pol2qm74	7795	7	with	with	IN
cord-015021-pol2qm74	7795	8	anti	anti	JJ
cord-015021-pol2qm74	7795	9	-	-	JJ
cord-015021-pol2qm74	7795	10	TNF	tnf	JJ
cord-015021-pol2qm74	7795	11	antibodies	antibody	NNS
cord-015021-pol2qm74	7795	12	and	and	CC
cord-015021-pol2qm74	7795	13	IL-1Ra	IL-1Ra	NNP
cord-015021-pol2qm74	7795	14	,	,	,
cord-015021-pol2qm74	7795	15	a	a	DT
cord-015021-pol2qm74	7795	16	naturally	naturally	RB
cord-015021-pol2qm74	7795	17	occurring	occur	VBG
cord-015021-pol2qm74	7795	18	IL-1	IL-1	NNP
cord-015021-pol2qm74	7795	19	antagonist	antagonist	NN
cord-015021-pol2qm74	7795	20	protein	protein	NN
cord-015021-pol2qm74	7795	21	,	,	,
cord-015021-pol2qm74	7795	22	have	have	VBP
cord-015021-pol2qm74	7795	23	risen	rise	VBN
cord-015021-pol2qm74	7795	24	debate	debate	NN
cord-015021-pol2qm74	7795	25	around	around	IN
cord-015021-pol2qm74	7795	26	the	the	DT
cord-015021-pol2qm74	7795	27	exceptional	exceptional	JJ
cord-015021-pol2qm74	7795	28	role	role	NN
cord-015021-pol2qm74	7795	29	of	of	IN
cord-015021-pol2qm74	7795	30	cytokines	cytokine	NNS
cord-015021-pol2qm74	7795	31	in	in	IN
cord-015021-pol2qm74	7795	32	the	the	DT
cord-015021-pol2qm74	7795	33	pathomechanism	pathomechanism	NN
cord-015021-pol2qm74	7795	34	of	of	IN
cord-015021-pol2qm74	7795	35	septic	septic	JJ
cord-015021-pol2qm74	7795	36	shock	shock	NN
cord-015021-pol2qm74	7795	37	or	or	CC
cord-015021-pol2qm74	7795	38	systemic	systemic	JJ
cord-015021-pol2qm74	7795	39	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7795	40	response	response	NN
cord-015021-pol2qm74	7795	41	syndrome	syndrome	NN
cord-015021-pol2qm74	7795	42	(	(	-LRB-
cord-015021-pol2qm74	7795	43	SIRS	SIRS	NNP
cord-015021-pol2qm74	7795	44	)	)	-RRB-
cord-015021-pol2qm74	7795	45	induced	induce	VBN
cord-015021-pol2qm74	7795	46	by	by	IN
cord-015021-pol2qm74	7795	47	Gramnegative	Gramnegative	NNP
cord-015021-pol2qm74	7795	48	microorganisms	microorganism	NNS
cord-015021-pol2qm74	7795	49	.	.	.
cord-015021-pol2qm74	7796	1	There	there	EX
cord-015021-pol2qm74	7796	2	are	be	VBP
cord-015021-pol2qm74	7796	3	similar	similar	JJ
cord-015021-pol2qm74	7796	4	problems	problem	NNS
cord-015021-pol2qm74	7796	5	with	with	IN
cord-015021-pol2qm74	7796	6	the	the	DT
cord-015021-pol2qm74	7796	7	interpretation	interpretation	NN
cord-015021-pol2qm74	7796	8	of	of	IN
cord-015021-pol2qm74	7796	9	the	the	DT
cord-015021-pol2qm74	7796	10	results	result	NNS
cord-015021-pol2qm74	7796	11	obtained	obtain	VBN
cord-015021-pol2qm74	7796	12	in	in	IN
cord-015021-pol2qm74	7796	13	clinical	clinical	JJ
cord-015021-pol2qm74	7796	14	trials	trial	NNS
cord-015021-pol2qm74	7796	15	of	of	IN
cord-015021-pol2qm74	7796	16	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7796	17	IgM	IgM	NNP
cord-015021-pol2qm74	7796	18	antibodies	antibody	NNS
cord-015021-pol2qm74	7796	19	against	against	IN
cord-015021-pol2qm74	7796	20	E.	E.	NNP
cord-015021-pol2qm74	7796	21	coli	coli	NNS
cord-015021-pol2qm74	7796	22	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7796	23	,	,	,
cord-015021-pol2qm74	7796	24	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	7796	25	and	and	CC
cord-015021-pol2qm74	7796	26	E5	E5	NNP
cord-015021-pol2qm74	7796	27	.	.	.
cord-015021-pol2qm74	7797	1	Future	future	JJ
cord-015021-pol2qm74	7797	2	studies	study	NNS
cord-015021-pol2qm74	7797	3	will	will	MD
cord-015021-pol2qm74	7797	4	answer	answer	VB
cord-015021-pol2qm74	7797	5	the	the	DT
cord-015021-pol2qm74	7797	6	question	question	NN
cord-015021-pol2qm74	7797	7	as	as	IN
cord-015021-pol2qm74	7797	8	to	to	IN
cord-015021-pol2qm74	7797	9	the	the	DT
cord-015021-pol2qm74	7797	10	effectivity	effectivity	NN
cord-015021-pol2qm74	7797	11	of	of	IN
cord-015021-pol2qm74	7797	12	inefficiency	inefficiency	NN
cord-015021-pol2qm74	7797	13	of	of	IN
cord-015021-pol2qm74	7797	14	this	this	DT
cord-015021-pol2qm74	7797	15	treatment	treatment	NN
cord-015021-pol2qm74	7797	16	.	.	.
cord-015021-pol2qm74	7798	1	Perhaps	perhaps	RB
cord-015021-pol2qm74	7798	2	when	when	WRB
cord-015021-pol2qm74	7798	3	the	the	DT
cord-015021-pol2qm74	7798	4	plasma	plasma	NN
cord-015021-pol2qm74	7798	5	concentrations	concentration	NNS
cord-015021-pol2qm74	7798	6	of	of	IN
cord-015021-pol2qm74	7798	7	LPS	lp	NNS
cord-015021-pol2qm74	7798	8	and	and	CC
cord-015021-pol2qm74	7798	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	7798	10	exceed	exceed	VBP
cord-015021-pol2qm74	7798	11	a	a	DT
cord-015021-pol2qm74	7798	12	critical	critical	JJ
cord-015021-pol2qm74	7798	13	level	level	NN
cord-015021-pol2qm74	7798	14	,	,	,
cord-015021-pol2qm74	7798	15	treatment	treatment	NN
cord-015021-pol2qm74	7798	16	fails	fail	VBZ
cord-015021-pol2qm74	7798	17	to	to	TO
cord-015021-pol2qm74	7798	18	save	save	VB
cord-015021-pol2qm74	7798	19	the	the	DT
cord-015021-pol2qm74	7798	20	patients	patient	NNS
cord-015021-pol2qm74	7798	21	life	life	NN
cord-015021-pol2qm74	7798	22	.	.	.
cord-015021-pol2qm74	7799	1	With	with	IN
cord-015021-pol2qm74	7799	2	regard	regard	VB
cord-015021-pol2qm74	7799	3	the	the	DT
cord-015021-pol2qm74	7799	4	causal	causal	JJ
cord-015021-pol2qm74	7799	5	role	role	NN
cord-015021-pol2qm74	7799	6	of	of	IN
cord-015021-pol2qm74	7799	7	LPS	LPS	NNP
cord-015021-pol2qm74	7799	8	in	in	IN
cord-015021-pol2qm74	7799	9	septic	septic	JJ
cord-015021-pol2qm74	7799	10	shock	shock	NN
cord-015021-pol2qm74	7799	11	,	,	,
cord-015021-pol2qm74	7799	12	the	the	DT
cord-015021-pol2qm74	7799	13	putative	putative	JJ
cord-015021-pol2qm74	7799	14	role	role	NN
cord-015021-pol2qm74	7799	15	of	of	IN
cord-015021-pol2qm74	7799	16	bacterial	bacterial	JJ
cord-015021-pol2qm74	7799	17	porins	porin	NNS
cord-015021-pol2qm74	7799	18	may	may	MD
cord-015021-pol2qm74	7799	19	have	have	VB
cord-015021-pol2qm74	7799	20	to	to	TO
cord-015021-pol2qm74	7799	21	be	be	VB
cord-015021-pol2qm74	7799	22	taken	take	VBN
cord-015021-pol2qm74	7799	23	into	into	IN
cord-015021-pol2qm74	7799	24	consideration	consideration	NN
cord-015021-pol2qm74	7799	25	.	.	.
cord-015021-pol2qm74	7800	1	The	the	DT
cord-015021-pol2qm74	7800	2	marked	marked	JJ
cord-015021-pol2qm74	7800	3	release	release	NN
cord-015021-pol2qm74	7800	4	of	of	IN
cord-015021-pol2qm74	7800	5	PAF	PAF	NNP
cord-015021-pol2qm74	7800	6	induced	induce	VBN
cord-015021-pol2qm74	7800	7	by	by	IN
cord-015021-pol2qm74	7800	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7800	9	leading	lead	VBG
cord-015021-pol2qm74	7800	10	to	to	IN
cord-015021-pol2qm74	7800	11	excess	excess	JJ
cord-015021-pol2qm74	7800	12	TXA2	TXA2	NNP
cord-015021-pol2qm74	7800	13	production	production	NN
cord-015021-pol2qm74	7800	14	may	may	MD
cord-015021-pol2qm74	7800	15	be	be	VB
cord-015021-pol2qm74	7800	16	responsible	responsible	JJ
cord-015021-pol2qm74	7800	17	for	for	IN
cord-015021-pol2qm74	7800	18	the	the	DT
cord-015021-pol2qm74	7800	19	microvascular	microvascular	JJ
cord-015021-pol2qm74	7800	20	failure	failure	NN
cord-015021-pol2qm74	7800	21	and	and	CC
cord-015021-pol2qm74	7800	22	death	death	NN
cord-015021-pol2qm74	7800	23	in	in	IN
cord-015021-pol2qm74	7800	24	septic	septic	JJ
cord-015021-pol2qm74	7800	25	shock	shock	NN
cord-015021-pol2qm74	7800	26	.	.	.
cord-015021-pol2qm74	7801	1	Antagonists	antagonist	NNS
cord-015021-pol2qm74	7801	2	of	of	IN
cord-015021-pol2qm74	7801	3	PAF	PAF	NNP
cord-015021-pol2qm74	7801	4	markedly	markedly	RB
cord-015021-pol2qm74	7801	5	protect	protect	VBP
cord-015021-pol2qm74	7801	6	against	against	IN
cord-015021-pol2qm74	7801	7	the	the	DT
cord-015021-pol2qm74	7801	8	release	release	NN
cord-015021-pol2qm74	7801	9	of	of	IN
cord-015021-pol2qm74	7801	10	TXA2	TXA2	NNP
cord-015021-pol2qm74	7801	11	,	,	,
cord-015021-pol2qm74	7801	12	and	and	CC
cord-015021-pol2qm74	7801	13	may	may	MD
cord-015021-pol2qm74	7801	14	interrupt	interrupt	VB
cord-015021-pol2qm74	7801	15	the	the	DT
cord-015021-pol2qm74	7801	16	vicious	vicious	JJ
cord-015021-pol2qm74	7801	17	circle	circle	NN
cord-015021-pol2qm74	7801	18	of	of	IN
cord-015021-pol2qm74	7801	19	amplification	amplification	NN
cord-015021-pol2qm74	7801	20	process	process	NN
cord-015021-pol2qm74	7801	21	.	.	.
cord-015021-pol2qm74	7802	1	NO	no	DT
cord-015021-pol2qm74	7802	2	produced	produce	VBN
cord-015021-pol2qm74	7802	3	by	by	IN
cord-015021-pol2qm74	7802	4	the	the	DT
cord-015021-pol2qm74	7802	5	inducible	inducible	JJ
cord-015021-pol2qm74	7802	6	NO	no	DT
cord-015021-pol2qm74	7802	7	synthase	synthase	NN
cord-015021-pol2qm74	7802	8	plays	play	VBZ
cord-015021-pol2qm74	7802	9	a	a	DT
cord-015021-pol2qm74	7802	10	pivotal	pivotal	JJ
cord-015021-pol2qm74	7802	11	role	role	NN
cord-015021-pol2qm74	7802	12	in	in	IN
cord-015021-pol2qm74	7802	13	causing	cause	VBG
cord-015021-pol2qm74	7802	14	vascular	vascular	JJ
cord-015021-pol2qm74	7802	15	paralysis	paralysis	NN
cord-015021-pol2qm74	7802	16	in	in	IN
cord-015021-pol2qm74	7802	17	LPS	LPS	NNP
cord-015021-pol2qm74	7802	18	-	-	HYPH
cord-015021-pol2qm74	7802	19	induced	induce	VBN
cord-015021-pol2qm74	7802	20	SIRS	SIRS	NNP
cord-015021-pol2qm74	7802	21	.	.	.
cord-015021-pol2qm74	7803	1	To	to	TO
cord-015021-pol2qm74	7803	2	explore	explore	VB
cord-015021-pol2qm74	7803	3	the	the	DT
cord-015021-pol2qm74	7803	4	relationship	relationship	NN
cord-015021-pol2qm74	7803	5	of	of	IN
cord-015021-pol2qm74	7803	6	PAF	PAF	NNP
cord-015021-pol2qm74	7803	7	to	to	IN
cord-015021-pol2qm74	7803	8	NO	no	DT
cord-015021-pol2qm74	7803	9	synthesis	synthesis	NN
cord-015021-pol2qm74	7803	10	will	will	MD
cord-015021-pol2qm74	7803	11	provide	provide	VB
cord-015021-pol2qm74	7803	12	better	well	JJR
cord-015021-pol2qm74	7803	13	understanding	understanding	NN
cord-015021-pol2qm74	7803	14	of	of	IN
cord-015021-pol2qm74	7803	15	the	the	DT
cord-015021-pol2qm74	7803	16	pathomechanism	pathomechanism	NN
cord-015021-pol2qm74	7803	17	of	of	IN
cord-015021-pol2qm74	7803	18	septic	septic	JJ
cord-015021-pol2qm74	7803	19	shock	shock	NN
cord-015021-pol2qm74	7803	20	.	.	.
cord-015021-pol2qm74	7804	1	Several	several	JJ
cord-015021-pol2qm74	7804	2	PAF	PAF	NNP
cord-015021-pol2qm74	7804	3	antagonists	antagonist	NNS
cord-015021-pol2qm74	7804	4	,	,	,
cord-015021-pol2qm74	7804	5	including	include	VBG
cord-015021-pol2qm74	7804	6	BN	BN	NNP
cord-015021-pol2qm74	7804	7	52021	52021	CD
cord-015021-pol2qm74	7804	8	,	,	,
cord-015021-pol2qm74	7804	9	have	have	VBP
cord-015021-pol2qm74	7804	10	undergone	undergo	VBN
cord-015021-pol2qm74	7804	11	phase	phase	NN
cord-015021-pol2qm74	7804	12	II	II	NNP
cord-015021-pol2qm74	7804	13	and	and	CC
cord-015021-pol2qm74	7804	14	phase	phase	NN
cord-015021-pol2qm74	7804	15	III	iii	CD
cord-015021-pol2qm74	7804	16	clinical	clinical	JJ
cord-015021-pol2qm74	7804	17	trials	trial	NNS
cord-015021-pol2qm74	7804	18	.	.	.
cord-015021-pol2qm74	7805	1	The	the	DT
cord-015021-pol2qm74	7805	2	strategy	strategy	NN
cord-015021-pol2qm74	7805	3	in	in	IN
cord-015021-pol2qm74	7805	4	the	the	DT
cord-015021-pol2qm74	7805	5	treatment	treatment	NN
cord-015021-pol2qm74	7805	6	of	of	IN
cord-015021-pol2qm74	7805	7	SIRS	SIRS	NNP
cord-015021-pol2qm74	7805	8	,	,	,
cord-015021-pol2qm74	7805	9	however	however	RB
cord-015021-pol2qm74	7805	10	,	,	,
cord-015021-pol2qm74	7805	11	remains	remain	VBZ
cord-015021-pol2qm74	7805	12	multifactorial	multifactorial	JJ
cord-015021-pol2qm74	7805	13	,	,	,
cord-015021-pol2qm74	7805	14	since	since	IN
cord-015021-pol2qm74	7805	15	little	little	JJ
cord-015021-pol2qm74	7805	16	is	be	VBZ
cord-015021-pol2qm74	7805	17	known	know	VBN
cord-015021-pol2qm74	7805	18	about	about	IN
cord-015021-pol2qm74	7805	19	the	the	DT
cord-015021-pol2qm74	7805	20	SIRS	SIRS	NNP
cord-015021-pol2qm74	7805	21	caused	cause	VBN
cord-015021-pol2qm74	7805	22	by	by	IN
cord-015021-pol2qm74	7805	23	microorganisms	microorganism	NNS
cord-015021-pol2qm74	7805	24	other	other	JJ
cord-015021-pol2qm74	7805	25	than	than	IN
cord-015021-pol2qm74	7805	26	Gram	gram	NN
cord-015021-pol2qm74	7805	27	-	-	HYPH
cord-015021-pol2qm74	7805	28	negative	negative	JJ
cord-015021-pol2qm74	7805	29	bacteria	bacteria	NNS
cord-015021-pol2qm74	7805	30	.	.	.
cord-015021-pol2qm74	7806	1	Evidence	evidence	NN
cord-015021-pol2qm74	7806	2	has	have	VBZ
cord-015021-pol2qm74	7806	3	begun	begin	VBN
cord-015021-pol2qm74	7806	4	to	to	TO
cord-015021-pol2qm74	7806	5	accumulate	accumulate	VB
cord-015021-pol2qm74	7806	6	which	which	WDT
cord-015021-pol2qm74	7806	7	suggests	suggest	VBZ
cord-015021-pol2qm74	7806	8	that	that	IN
cord-015021-pol2qm74	7806	9	in	in	IN
cord-015021-pol2qm74	7806	10	sepsis	sepsis	NN
cord-015021-pol2qm74	7806	11	excess	excess	JJ
cord-015021-pol2qm74	7806	12	production	production	NN
cord-015021-pol2qm74	7806	13	of	of	IN
cord-015021-pol2qm74	7806	14	LPS	lp	NNS
cord-015021-pol2qm74	7806	15	and	and	CC
cord-015021-pol2qm74	7806	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	7806	17	can	can	MD
cord-015021-pol2qm74	7806	18	lead	lead	VB
cord-015021-pol2qm74	7806	19	to	to	IN
cord-015021-pol2qm74	7806	20	uncontrolled	uncontrolled	JJ
cord-015021-pol2qm74	7806	21	production	production	NN
cord-015021-pol2qm74	7806	22	of	of	IN
cord-015021-pol2qm74	7806	23	iNOS	inos	NN
cord-015021-pol2qm74	7806	24	and	and	CC
cord-015021-pol2qm74	7806	25	that	that	IN
cord-015021-pol2qm74	7806	26	this	this	DT
cord-015021-pol2qm74	7806	27	might	may	MD
cord-015021-pol2qm74	7806	28	in	in	IN
cord-015021-pol2qm74	7806	29	part	part	NN
cord-015021-pol2qm74	7806	30	explain	explain	VB
cord-015021-pol2qm74	7806	31	the	the	DT
cord-015021-pol2qm74	7806	32	severe	severe	JJ
cord-015021-pol2qm74	7806	33	unresponsive	unresponsive	JJ
cord-015021-pol2qm74	7806	34	hypotension	hypotension	NN
cord-015021-pol2qm74	7806	35	seen	see	VBN
cord-015021-pol2qm74	7806	36	in	in	IN
cord-015021-pol2qm74	7806	37	some	some	DT
cord-015021-pol2qm74	7806	38	septic	septic	JJ
cord-015021-pol2qm74	7806	39	patients	patient	NNS
cord-015021-pol2qm74	7806	40	.	.	.
cord-015021-pol2qm74	7807	1	A	a	DT
cord-015021-pol2qm74	7807	2	number	number	NN
cord-015021-pol2qm74	7807	3	of	of	IN
cord-015021-pol2qm74	7807	4	strategies	strategy	NNS
cord-015021-pol2qm74	7807	5	have	have	VBP
cord-015021-pol2qm74	7807	6	been	be	VBN
cord-015021-pol2qm74	7807	7	explored	explore	VBN
cord-015021-pol2qm74	7807	8	in	in	IN
cord-015021-pol2qm74	7807	9	an	an	DT
cord-015021-pol2qm74	7807	10	attempt	attempt	NN
cord-015021-pol2qm74	7807	11	to	to	TO
cord-015021-pol2qm74	7807	12	limit	limit	VB
cord-015021-pol2qm74	7807	13	excess	excess	JJ
cord-015021-pol2qm74	7807	14	NO	no	DT
cord-015021-pol2qm74	7807	15	production	production	NN
cord-015021-pol2qm74	7807	16	.	.	.
cord-015021-pol2qm74	7808	1	A	a	DT
cord-015021-pol2qm74	7808	2	favourite	favourite	JJ
cord-015021-pol2qm74	7808	3	target	target	NN
cord-015021-pol2qm74	7808	4	has	have	VBZ
cord-015021-pol2qm74	7808	5	been	be	VBN
cord-015021-pol2qm74	7808	6	competitive	competitive	JJ
cord-015021-pol2qm74	7808	7	inhibition	inhibition	NN
cord-015021-pol2qm74	7808	8	of	of	IN
cord-015021-pol2qm74	7808	9	NOS	NOS	NNP
cord-015021-pol2qm74	7808	10	by	by	IN
cord-015021-pol2qm74	7808	11	arginine	arginine	NN
cord-015021-pol2qm74	7808	12	analogues	analogue	NNS
cord-015021-pol2qm74	7808	13	such	such	JJ
cord-015021-pol2qm74	7808	14	as	as	IN
cord-015021-pol2qm74	7808	15	L	L	NNP
cord-015021-pol2qm74	7808	16	-	-	HYPH
cord-015021-pol2qm74	7808	17	NMMA	NMMA	NNP
cord-015021-pol2qm74	7808	18	.	.	.
cord-015021-pol2qm74	7809	1	In	in	IN
cord-015021-pol2qm74	7809	2	animals	animal	NNS
cord-015021-pol2qm74	7809	3	,	,	,
cord-015021-pol2qm74	7809	4	some	some	DT
cord-015021-pol2qm74	7809	5	investigators	investigator	NNS
cord-015021-pol2qm74	7809	6	have	have	VBP
cord-015021-pol2qm74	7809	7	shown	show	VBN
cord-015021-pol2qm74	7809	8	that	that	IN
cord-015021-pol2qm74	7809	9	the	the	DT
cord-015021-pol2qm74	7809	10	haemodynamic	haemodynamic	JJ
cord-015021-pol2qm74	7809	11	effects	effect	NNS
cord-015021-pol2qm74	7809	12	of	of	IN
cord-015021-pol2qm74	7809	13	LPS	LPS	NNP
cord-015021-pol2qm74	7809	14	challenge	challenge	NN
cord-015021-pol2qm74	7809	15	can	can	MD
cord-015021-pol2qm74	7809	16	be	be	VB
cord-015021-pol2qm74	7809	17	attenuated	attenuate	VBN
cord-015021-pol2qm74	7809	18	by	by	IN
cord-015021-pol2qm74	7809	19	L	L	NNP
cord-015021-pol2qm74	7809	20	-	-	HYPH
cord-015021-pol2qm74	7809	21	NMMA	NMMA	NNP
cord-015021-pol2qm74	7809	22	,	,	,
cord-015021-pol2qm74	7809	23	but	but	CC
cord-015021-pol2qm74	7809	24	there	there	EX
cord-015021-pol2qm74	7809	25	is	be	VBZ
cord-015021-pol2qm74	7809	26	a	a	DT
cord-015021-pol2qm74	7809	27	narrow	narrow	JJ
cord-015021-pol2qm74	7809	28	toxic	toxic	JJ
cord-015021-pol2qm74	7809	29	-	-	HYPH
cord-015021-pol2qm74	7809	30	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7809	31	ratio	ratio	NN
cord-015021-pol2qm74	7809	32	.	.	.
cord-015021-pol2qm74	7810	1	In	in	IN
cord-015021-pol2qm74	7810	2	a	a	DT
cord-015021-pol2qm74	7810	3	model	model	NN
cord-015021-pol2qm74	7810	4	of	of	IN
cord-015021-pol2qm74	7810	5	live	live	JJ
cord-015021-pol2qm74	7810	6	E.	E.	NNP
cord-015021-pol2qm74	7810	7	cell	cell	NN
cord-015021-pol2qm74	7810	8	sepsis	sepsis	NN
cord-015021-pol2qm74	7810	9	,	,	,
cord-015021-pol2qm74	7810	10	we	-PRON-	PRP
cord-015021-pol2qm74	7810	11	have	have	VBP
cord-015021-pol2qm74	7810	12	been	be	VBN
cord-015021-pol2qm74	7810	13	unable	unable	JJ
cord-015021-pol2qm74	7810	14	to	to	TO
cord-015021-pol2qm74	7810	15	reproduce	reproduce	VB
cord-015021-pol2qm74	7810	16	these	these	DT
cord-015021-pol2qm74	7810	17	findings	finding	NNS
cord-015021-pol2qm74	7810	18	.	.	.
cord-015021-pol2qm74	7811	1	Localisation	localisation	NN
cord-015021-pol2qm74	7811	2	of	of	IN
cord-015021-pol2qm74	7811	3	NO	no	DT
cord-015021-pol2qm74	7811	4	production	production	NN
cord-015021-pol2qm74	7811	5	by	by	IN
cord-015021-pol2qm74	7811	6	immunohistochemistry	immunohistochemistry	NN
cord-015021-pol2qm74	7811	7	suggests	suggest	VBZ
cord-015021-pol2qm74	7811	8	that	that	IN
cord-015021-pol2qm74	7811	9	NO	no	DT
cord-015021-pol2qm74	7811	10	production	production	NN
cord-015021-pol2qm74	7811	11	is	be	VBZ
cord-015021-pol2qm74	7811	12	compartmentalised	compartmentalise	VBN
cord-015021-pol2qm74	7811	13	,	,	,
cord-015021-pol2qm74	7811	14	and	and	CC
cord-015021-pol2qm74	7811	15	more	more	RBR
cord-015021-pol2qm74	7811	16	subtle	subtle	JJ
cord-015021-pol2qm74	7811	17	methods	method	NNS
cord-015021-pol2qm74	7811	18	of	of	IN
cord-015021-pol2qm74	7811	19	regulation	regulation	NN
cord-015021-pol2qm74	7811	20	may	may	MD
cord-015021-pol2qm74	7811	21	be	be	VB
cord-015021-pol2qm74	7811	22	required	require	VBN
cord-015021-pol2qm74	7811	23	if	if	IN
cord-015021-pol2qm74	7811	24	this	this	DT
cord-015021-pol2qm74	7811	25	approach	approach	NN
cord-015021-pol2qm74	7811	26	is	be	VBZ
cord-015021-pol2qm74	7811	27	to	to	TO
cord-015021-pol2qm74	7811	28	have	have	VB
cord-015021-pol2qm74	7811	29	clinical	clinical	JJ
cord-015021-pol2qm74	7811	30	valuc	valuc	NN
cord-015021-pol2qm74	7811	31	.	.	.
cord-015021-pol2qm74	7812	1	Anti	anti	JJ
cord-015021-pol2qm74	7812	2	-	-	JJ
cord-015021-pol2qm74	7812	3	adhesion	adhesion	NN
cord-015021-pol2qm74	7812	4	molecule	molecule	NN
cord-015021-pol2qm74	7812	5	strategies	strategy	NNS
cord-015021-pol2qm74	7812	6	CH	CH	NNP
cord-015021-pol2qm74	7812	7	Wortel	Wortel	NNP
cord-015021-pol2qm74	7812	8	,	,	,
cord-015021-pol2qm74	7812	9	Repligen	Repligen	NNP
cord-015021-pol2qm74	7812	10	Corporation	Corporation	NNP
cord-015021-pol2qm74	7812	11	,	,	,
cord-015021-pol2qm74	7812	12	One	one	CD
cord-015021-pol2qm74	7812	13	Kendall	Kendall	NNP
cord-015021-pol2qm74	7812	14	Square	Square	NNP
cord-015021-pol2qm74	7812	15	,	,	,
cord-015021-pol2qm74	7812	16	Building	Building	NNP
cord-015021-pol2qm74	7812	17	700	700	CD
cord-015021-pol2qm74	7812	18	,	,	,
cord-015021-pol2qm74	7812	19	Cambridge	Cambridge	NNP
cord-015021-pol2qm74	7812	20	,	,	,
cord-015021-pol2qm74	7812	21	MA	MA	NNP
cord-015021-pol2qm74	7812	22	02139	02139	CD
cord-015021-pol2qm74	7812	23	,	,	,
cord-015021-pol2qm74	7812	24	USA	USA	NNP
cord-015021-pol2qm74	7812	25	.	.	.
cord-015021-pol2qm74	7813	1	The	the	DT
cord-015021-pol2qm74	7813	2	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7813	3	has	have	VBZ
cord-015021-pol2qm74	7813	4	been	be	VBN
cord-015021-pol2qm74	7813	5	implicated	implicate	VBN
cord-015021-pol2qm74	7813	6	as	as	IN
cord-015021-pol2qm74	7813	7	a	a	DT
cord-015021-pol2qm74	7813	8	pivotal	pivotal	JJ
cord-015021-pol2qm74	7813	9	player	player	NN
cord-015021-pol2qm74	7813	10	in	in	IN
cord-015021-pol2qm74	7813	11	the	the	DT
cord-015021-pol2qm74	7813	12	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	7813	13	of	of	IN
cord-015021-pol2qm74	7813	14	multiple	multiple	JJ
cord-015021-pol2qm74	7813	15	organ	organ	NN
cord-015021-pol2qm74	7813	16	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7813	17	.	.	.
cord-015021-pol2qm74	7814	1	An	an	DT
cord-015021-pol2qm74	7814	2	important	important	JJ
cord-015021-pol2qm74	7814	3	first	first	JJ
cord-015021-pol2qm74	7814	4	step	step	NN
cord-015021-pol2qm74	7814	5	in	in	IN
cord-015021-pol2qm74	7814	6	the	the	DT
cord-015021-pol2qm74	7814	7	process	process	NN
cord-015021-pol2qm74	7814	8	of	of	IN
cord-015021-pol2qm74	7814	9	neutrophilmediated	neutrophilmediated	JJ
cord-015021-pol2qm74	7814	10	organ	organ	NNP
cord-015021-pol2qm74	7814	11	injury	injury	NN
cord-015021-pol2qm74	7814	12	involves	involve	VBZ
cord-015021-pol2qm74	7814	13	the	the	DT
cord-015021-pol2qm74	7814	14	binding	binding	NN
cord-015021-pol2qm74	7814	15	of	of	IN
cord-015021-pol2qm74	7814	16	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7814	17	to	to	IN
cord-015021-pol2qm74	7814	18	endothelial	endothelial	JJ
cord-015021-pol2qm74	7814	19	ceils	ceil	NNS
cord-015021-pol2qm74	7814	20	.	.	.
cord-015021-pol2qm74	7815	1	This	this	DT
cord-015021-pol2qm74	7815	2	process	process	NN
cord-015021-pol2qm74	7815	3	is	be	VBZ
cord-015021-pol2qm74	7815	4	largely	largely	RB
cord-015021-pol2qm74	7815	5	regulated	regulate	VBN
cord-015021-pol2qm74	7815	6	by	by	IN
cord-015021-pol2qm74	7815	7	complementary	complementary	JJ
cord-015021-pol2qm74	7815	8	adhesion	adhesion	NN
cord-015021-pol2qm74	7815	9	molecules	molecule	NNS
cord-015021-pol2qm74	7815	10	,	,	,
cord-015021-pol2qm74	7815	11	some	some	DT
cord-015021-pol2qm74	7815	12	of	of	IN
cord-015021-pol2qm74	7815	13	which	which	WDT
cord-015021-pol2qm74	7815	14	are	be	VBP
cord-015021-pol2qm74	7815	15	present	present	JJ
cord-015021-pol2qm74	7815	16	constitutively	constitutively	RB
cord-015021-pol2qm74	7815	17	on	on	IN
cord-015021-pol2qm74	7815	18	the	the	DT
cord-015021-pol2qm74	7815	19	cell	cell	NN
cord-015021-pol2qm74	7815	20	surface	surface	NN
cord-015021-pol2qm74	7815	21	and	and	CC
cord-015021-pol2qm74	7815	22	others	other	NNS
cord-015021-pol2qm74	7815	23	that	that	WDT
cord-015021-pol2qm74	7815	24	can	can	MD
cord-015021-pol2qm74	7815	25	be	be	VB
cord-015021-pol2qm74	7815	26	upregulated	upregulate	VBN
cord-015021-pol2qm74	7815	27	in	in	IN
cord-015021-pol2qm74	7815	28	response	response	NN
cord-015021-pol2qm74	7815	29	to	to	IN
cord-015021-pol2qm74	7815	30	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	7815	31	and	and	CC
cord-015021-pol2qm74	7815	32	pro	pro	JJ
cord-015021-pol2qm74	7815	33	-	-	JJ
cord-015021-pol2qm74	7815	34	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7815	35	stimuli	stimulus	NNS
cord-015021-pol2qm74	7815	36	.	.	.
cord-015021-pol2qm74	7816	1	Several	several	JJ
cord-015021-pol2qm74	7816	2	different	different	JJ
cord-015021-pol2qm74	7816	3	adhesion	adhesion	NN
cord-015021-pol2qm74	7816	4	molecules	molecule	NNS
cord-015021-pol2qm74	7816	5	have	have	VBP
cord-015021-pol2qm74	7816	6	been	be	VBN
cord-015021-pol2qm74	7816	7	described	describe	VBN
cord-015021-pol2qm74	7816	8	.	.	.
cord-015021-pol2qm74	7817	1	L	L	NNP
cord-015021-pol2qm74	7817	2	-	-	HYPH
cord-015021-pol2qm74	7817	3	selec	selec	NNP
cord-015021-pol2qm74	7817	4	tin	tin	NN
cord-015021-pol2qm74	7817	5	is	be	VBZ
cord-015021-pol2qm74	7817	6	expressed	express	VBN
cord-015021-pol2qm74	7817	7	on	on	IN
cord-015021-pol2qm74	7817	8	the	the	DT
cord-015021-pol2qm74	7817	9	plasma	plasma	NN
cord-015021-pol2qm74	7817	10	membrane	membrane	NN
cord-015021-pol2qm74	7817	11	of	of	IN
cord-015021-pol2qm74	7817	12	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7817	13	and	and	CC
cord-015021-pol2qm74	7817	14	is	be	VBZ
cord-015021-pol2qm74	7817	15	shed	shed	VBN
cord-015021-pol2qm74	7817	16	from	from	IN
cord-015021-pol2qm74	7817	17	the	the	DT
cord-015021-pol2qm74	7817	18	surface	surface	NN
cord-015021-pol2qm74	7817	19	early	early	RB
cord-015021-pol2qm74	7817	20	in	in	IN
cord-015021-pol2qm74	7817	21	the	the	DT
cord-015021-pol2qm74	7817	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7817	23	process	process	NN
cord-015021-pol2qm74	7817	24	.	.	.
cord-015021-pol2qm74	7818	1	It	-PRON-	PRP
cord-015021-pol2qm74	7818	2	is	be	VBZ
cord-015021-pol2qm74	7818	3	therefore	therefore	RB
cord-015021-pol2qm74	7818	4	thought	think	VBN
cord-015021-pol2qm74	7818	5	to	to	TO
cord-015021-pol2qm74	7818	6	mediate	mediate	VB
cord-015021-pol2qm74	7818	7	the	the	DT
cord-015021-pol2qm74	7818	8	initial	initial	JJ
cord-015021-pol2qm74	7818	9	interactions	interaction	NNS
cord-015021-pol2qm74	7818	10	with	with	IN
cord-015021-pol2qm74	7818	11	endothelial	endothelial	JJ
cord-015021-pol2qm74	7818	12	cells	cell	NNS
cord-015021-pol2qm74	7818	13	.	.	.
cord-015021-pol2qm74	7819	1	E	e	LS
cord-015021-pol2qm74	7819	2	-	-	NN
cord-015021-pol2qm74	7819	3	selectin	selectin	NN
cord-015021-pol2qm74	7819	4	and	and	CC
cord-015021-pol2qm74	7819	5	P	p	NN
cord-015021-pol2qm74	7819	6	-	-	HYPH
cord-015021-pol2qm74	7819	7	selectin	selectin	NNP
cord-015021-pol2qm74	7819	8	are	be	VBP
cord-015021-pol2qm74	7819	9	endothelial	endothelial	JJ
cord-015021-pol2qm74	7819	10	adhesion	adhesion	NN
cord-015021-pol2qm74	7819	11	molecules	molecule	NNS
cord-015021-pol2qm74	7819	12	.	.	.
cord-015021-pol2qm74	7820	1	E	E	NNP
cord-015021-pol2qm74	7820	2	-	-	NN
cord-015021-pol2qm74	7820	3	selectin	selectin	NNP
cord-015021-pol2qm74	7820	4	is	be	VBZ
cord-015021-pol2qm74	7820	5	not	not	RB
cord-015021-pol2qm74	7820	6	constitutively	constitutively	RB
cord-015021-pol2qm74	7820	7	expressed	express	VBN
cord-015021-pol2qm74	7820	8	but	but	CC
cord-015021-pol2qm74	7820	9	is	be	VBZ
cord-015021-pol2qm74	7820	10	upregulated	upregulate	VBN
cord-015021-pol2qm74	7820	11	by	by	IN
cord-015021-pol2qm74	7820	12	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7820	13	mediators	mediator	NNS
cord-015021-pol2qm74	7820	14	,	,	,
cord-015021-pol2qm74	7820	15	particularly	particularly	RB
cord-015021-pol2qm74	7820	16	IL-1	IL-1	NNP
cord-015021-pol2qm74	7820	17	and	and	CC
cord-015021-pol2qm74	7820	18	TNF	TNF	NNP
cord-015021-pol2qm74	7820	19	.	.	.
cord-015021-pol2qm74	7821	1	P	p	NN
cord-015021-pol2qm74	7821	2	-	-	HYPH
cord-015021-pol2qm74	7821	3	selectin	selectin	NNP
cord-015021-pol2qm74	7821	4	is	be	VBZ
cord-015021-pol2qm74	7821	5	present	present	JJ
cord-015021-pol2qm74	7821	6	in	in	IN
cord-015021-pol2qm74	7821	7	the	the	DT
cord-015021-pol2qm74	7821	8	Weibel	Weibel	NNP
cord-015021-pol2qm74	7821	9	-	-	HYPH
cord-015021-pol2qm74	7821	10	Palade	Palade	NNP
cord-015021-pol2qm74	7821	11	bodies	body	NNS
cord-015021-pol2qm74	7821	12	within	within	IN
cord-015021-pol2qm74	7821	13	the	the	DT
cord-015021-pol2qm74	7821	14	endothelial	endothelial	JJ
cord-015021-pol2qm74	7821	15	cytoplasm	cytoplasm	NN
cord-015021-pol2qm74	7821	16	and	and	CC
cord-015021-pol2qm74	7821	17	can	can	MD
cord-015021-pol2qm74	7821	18	be	be	VB
cord-015021-pol2qm74	7821	19	upregulated	upregulate	VBN
cord-015021-pol2qm74	7821	20	rapidly	rapidly	RB
cord-015021-pol2qm74	7821	21	in	in	IN
cord-015021-pol2qm74	7821	22	response	response	NN
cord-015021-pol2qm74	7821	23	to	to	IN
cord-015021-pol2qm74	7821	24	thrombin	thrombin	NN
cord-015021-pol2qm74	7821	25	,	,	,
cord-015021-pol2qm74	7821	26	histamine	histamine	NN
cord-015021-pol2qm74	7821	27	,	,	,
cord-015021-pol2qm74	7821	28	and	and	CC
cord-015021-pol2qm74	7821	29	oxidants	oxidant	NNS
cord-015021-pol2qm74	7821	30	.	.	.
cord-015021-pol2qm74	7822	1	All	all	DT
cord-015021-pol2qm74	7822	2	selectins	selectin	NNS
cord-015021-pol2qm74	7822	3	recognize	recognize	VBP
cord-015021-pol2qm74	7822	4	oligosaccharides	oligosaccharide	NNS
cord-015021-pol2qm74	7822	5	,	,	,
cord-015021-pol2qm74	7822	6	particularly	particularly	RB
cord-015021-pol2qm74	7822	7	sialylated	sialylate	VBN
cord-015021-pol2qm74	7822	8	Lewis	Lewis	NNP
cord-015021-pol2qm74	7822	9	X	X	NNP
cord-015021-pol2qm74	7822	10	antigen	antigen	NN
cord-015021-pol2qm74	7822	11	.	.	.
cord-015021-pol2qm74	7823	1	This	this	DT
cord-015021-pol2qm74	7823	2	carbohydrate	carbohydrate	NN
cord-015021-pol2qm74	7823	3	moiety	moiety	NN
cord-015021-pol2qm74	7823	4	is	be	VBZ
cord-015021-pol2qm74	7823	5	expressed	express	VBN
cord-015021-pol2qm74	7823	6	on	on	IN
cord-015021-pol2qm74	7823	7	many	many	JJ
cord-015021-pol2qm74	7823	8	proteins	protein	NNS
cord-015021-pol2qm74	7823	9	,	,	,
cord-015021-pol2qm74	7823	10	including	include	VBG
cord-015021-pol2qm74	7823	11	the	the	DT
cord-015021-pol2qm74	7823	12	selectins	selectin	NNS
cord-015021-pol2qm74	7823	13	themselves	-PRON-	PRP
cord-015021-pol2qm74	7823	14	.	.	.
cord-015021-pol2qm74	7824	1	The	the	DT
cord-015021-pol2qm74	7824	2	leukocyte	leukocyte	NN
cord-015021-pol2qm74	7824	3	integrins	integrin	NNS
cord-015021-pol2qm74	7824	4	are	be	VBP
cord-015021-pol2qm74	7824	5	glycoproteins	glycoprotein	NNS
cord-015021-pol2qm74	7824	6	expressed	express	VBN
cord-015021-pol2qm74	7824	7	on	on	IN
cord-015021-pol2qm74	7824	8	the	the	DT
cord-015021-pol2qm74	7824	9	neutrophil	neutrophil	NN
cord-015021-pol2qm74	7824	10	surface	surface	NN
cord-015021-pol2qm74	7824	11	and	and	CC
cord-015021-pol2qm74	7824	12	in	in	IN
cord-015021-pol2qm74	7824	13	the	the	DT
cord-015021-pol2qm74	7824	14	cytoplasmic	cytoplasmic	JJ
cord-015021-pol2qm74	7824	15	granules	granule	NNS
cord-015021-pol2qm74	7824	16	.	.	.
cord-015021-pol2qm74	7825	1	Integrins	integrin	NNS
cord-015021-pol2qm74	7825	2	consist	consist	VBP
cord-015021-pol2qm74	7825	3	of	of	IN
cord-015021-pol2qm74	7825	4	a	a	DT
cord-015021-pol2qm74	7825	5	common	common	JJ
cord-015021-pol2qm74	7825	6	beta2	beta2	NN
cord-015021-pol2qm74	7825	7	or	or	CC
cord-015021-pol2qm74	7825	8	cluster	cluster	NN
cord-015021-pol2qm74	7825	9	differentiation	differentiation	NN
cord-015021-pol2qm74	7825	10	(	(	-LRB-
cord-015021-pol2qm74	7825	11	CD)I	CD)I	NNP
cord-015021-pol2qm74	7825	12	8	8	CD
cord-015021-pol2qm74	7825	13	chain	chain	NN
cord-015021-pol2qm74	7825	14	covalently	covalently	RB
cord-015021-pol2qm74	7825	15	linked	link	VBN
cord-015021-pol2qm74	7825	16	to	to	IN
cord-015021-pol2qm74	7825	17	one	one	CD
cord-015021-pol2qm74	7825	18	of	of	IN
cord-015021-pol2qm74	7825	19	three	three	CD
cord-015021-pol2qm74	7825	20	different	different	JJ
cord-015021-pol2qm74	7825	21	alpha	alpha	NN
cord-015021-pol2qm74	7825	22	chains	chain	NNS
cord-015021-pol2qm74	7825	23	(	(	-LRB-
cord-015021-pol2qm74	7825	24	CD11	CD11	NNP
cord-015021-pol2qm74	7825	25	a	a	DT
cord-015021-pol2qm74	7825	26	,	,	,
cord-015021-pol2qm74	7825	27	CD1	CD1	NNP
cord-015021-pol2qm74	7825	28	lb	lb	NNP
cord-015021-pol2qm74	7825	29	,	,	,
cord-015021-pol2qm74	7825	30	CD1	CD1	NNP
cord-015021-pol2qm74	7825	31	lc	lc	NNP
cord-015021-pol2qm74	7825	32	)	)	-RRB-
cord-015021-pol2qm74	7825	33	and	and	CC
cord-015021-pol2qm74	7825	34	exist	exist	VBP
cord-015021-pol2qm74	7825	35	on	on	IN
cord-015021-pol2qm74	7825	36	the	the	DT
cord-015021-pol2qm74	7825	37	cell	cell	NN
cord-015021-pol2qm74	7825	38	surface	surface	NN
cord-015021-pol2qm74	7825	39	as	as	IN
cord-015021-pol2qm74	7825	40	three	three	CD
cord-015021-pol2qm74	7825	41	distinct	distinct	JJ
cord-015021-pol2qm74	7825	42	heterodimers	heterodimer	NNS
cord-015021-pol2qm74	7825	43	.	.	.
cord-015021-pol2qm74	7826	1	CD1	CD1	NNP
cord-015021-pol2qm74	7826	2	l	l	NNP
cord-015021-pol2qm74	7826	3	a	a	NNP
cord-015021-pol2qm74	7826	4	/	/	SYM
cord-015021-pol2qm74	7826	5	CDI	CDI	NNP
cord-015021-pol2qm74	7826	6	8	8	CD
cord-015021-pol2qm74	7826	7	is	be	VBZ
cord-015021-pol2qm74	7826	8	expressed	express	VBN
cord-015021-pol2qm74	7826	9	on	on	IN
cord-015021-pol2qm74	7826	10	all	all	DT
cord-015021-pol2qm74	7826	11	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	7826	12	,	,	,
cord-015021-pol2qm74	7826	13	whereas	whereas	IN
cord-015021-pol2qm74	7826	14	CD1	CD1	NNP
cord-015021-pol2qm74	7826	15	l	l	NNP
cord-015021-pol2qm74	7826	16	b/	b/	NN
cord-015021-pol2qm74	7826	17	CD18	CD18	NNP
cord-015021-pol2qm74	7826	18	and	and	CC
cord-015021-pol2qm74	7826	19	CD1	CD1	NNP
cord-015021-pol2qm74	7826	20	lc	lc	NNP
cord-015021-pol2qm74	7826	21	/	/	SYM
cord-015021-pol2qm74	7826	22	CD18	CD18	NNP
cord-015021-pol2qm74	7826	23	are	be	VBP
cord-015021-pol2qm74	7826	24	restricted	restrict	VBN
cord-015021-pol2qm74	7826	25	to	to	IN
cord-015021-pol2qm74	7826	26	cells	cell	NNS
cord-015021-pol2qm74	7826	27	of	of	IN
cord-015021-pol2qm74	7826	28	myeloid	myeloid	JJ
cord-015021-pol2qm74	7826	29	origin	origin	NN
cord-015021-pol2qm74	7826	30	.	.	.
cord-015021-pol2qm74	7827	1	CD1	CD1	NNP
cord-015021-pol2qm74	7827	2	I	I	NNP
cord-015021-pol2qm74	7827	3	/	/	SYM
cord-015021-pol2qm74	7827	4	CD18	CD18	NNP
cord-015021-pol2qm74	7827	5	interacts	interact	VBZ
cord-015021-pol2qm74	7827	6	with	with	IN
cord-015021-pol2qm74	7827	7	intracellular	intracellular	JJ
cord-015021-pol2qm74	7827	8	adhesion	adhesion	NN
cord-015021-pol2qm74	7827	9	molecule-1	molecule-1	NN
cord-015021-pol2qm74	7827	10	(	(	-LRB-
cord-015021-pol2qm74	7827	11	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	7827	12	)	)	-RRB-
cord-015021-pol2qm74	7827	13	,	,	,
cord-015021-pol2qm74	7827	14	its	-PRON-	PRP$
cord-015021-pol2qm74	7827	15	ligand	ligand	NN
cord-015021-pol2qm74	7827	16	on	on	IN
cord-015021-pol2qm74	7827	17	endothelial	endothelial	JJ
cord-015021-pol2qm74	7827	18	cells	cell	NNS
cord-015021-pol2qm74	7827	19	.	.	.
cord-015021-pol2qm74	7828	1	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	7828	2	is	be	VBZ
cord-015021-pol2qm74	7828	3	a	a	DT
cord-015021-pol2qm74	7828	4	member	member	NN
cord-015021-pol2qm74	7828	5	of	of	IN
cord-015021-pol2qm74	7828	6	the	the	DT
cord-015021-pol2qm74	7828	7	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	7828	8	family	family	NN
cord-015021-pol2qm74	7828	9	of	of	IN
cord-015021-pol2qm74	7828	10	adhesion	adhesion	NN
cord-015021-pol2qm74	7828	11	molecules	molecule	NNS
cord-015021-pol2qm74	7828	12	.	.	.
cord-015021-pol2qm74	7829	1	It	-PRON-	PRP
cord-015021-pol2qm74	7829	2	is	be	VBZ
cord-015021-pol2qm74	7829	3	constitutively	constitutively	RB
cord-015021-pol2qm74	7829	4	expressed	express	VBN
cord-015021-pol2qm74	7829	5	on	on	IN
cord-015021-pol2qm74	7829	6	endothelial	endothelial	JJ
cord-015021-pol2qm74	7829	7	cells	cell	NNS
cord-015021-pol2qm74	7829	8	and	and	CC
cord-015021-pol2qm74	7829	9	can	can	MD
cord-015021-pol2qm74	7829	10	be	be	VB
cord-015021-pol2qm74	7829	11	upregulated	upregulate	VBN
cord-015021-pol2qm74	7829	12	by	by	IN
cord-015021-pol2qm74	7829	13	cytokines	cytokine	NNS
cord-015021-pol2qm74	7829	14	.	.	.
cord-015021-pol2qm74	7830	1	The	the	DT
cord-015021-pol2qm74	7830	2	potential	potential	NN
cord-015021-pol2qm74	7830	3	for	for	IN
cord-015021-pol2qm74	7830	4	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7830	5	antibodies	antibody	NNS
cord-015021-pol2qm74	7830	6	to	to	TO
cord-015021-pol2qm74	7830	7	adhesion	adhesion	NN
cord-015021-pol2qm74	7830	8	proteins	protein	NNS
cord-015021-pol2qm74	7830	9	to	to	TO
cord-015021-pol2qm74	7830	10	reduce	reduce	VB
cord-015021-pol2qm74	7830	11	vascular	vascular	JJ
cord-015021-pol2qm74	7830	12	and	and	CC
cord-015021-pol2qm74	7830	13	tissue	tissue	NN
cord-015021-pol2qm74	7830	14	damage	damage	NN
cord-015021-pol2qm74	7830	15	has	have	VBZ
cord-015021-pol2qm74	7830	16	been	be	VBN
cord-015021-pol2qm74	7830	17	studied	study	VBN
cord-015021-pol2qm74	7830	18	in	in	IN
cord-015021-pol2qm74	7830	19	alarge	alarge	NN
cord-015021-pol2qm74	7830	20	number	number	NN
cord-015021-pol2qm74	7830	21	of	of	IN
cord-015021-pol2qm74	7830	22	experimental	experimental	JJ
cord-015021-pol2qm74	7830	23	models	model	NNS
cord-015021-pol2qm74	7830	24	.	.	.
cord-015021-pol2qm74	7831	1	Protective	protective	JJ
cord-015021-pol2qm74	7831	2	effects	effect	NNS
cord-015021-pol2qm74	7831	3	have	have	VBP
cord-015021-pol2qm74	7831	4	been	be	VBN
cord-015021-pol2qm74	7831	5	observed	observe	VBN
cord-015021-pol2qm74	7831	6	in	in	IN
cord-015021-pol2qm74	7831	7	a	a	DT
cord-015021-pol2qm74	7831	8	wide	wide	JJ
cord-015021-pol2qm74	7831	9	variety	variety	NN
cord-015021-pol2qm74	7831	10	of	of	IN
cord-015021-pol2qm74	7831	11	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7831	12	,	,	,
cord-015021-pol2qm74	7831	13	immune	immune	JJ
cord-015021-pol2qm74	7831	14	,	,	,
cord-015021-pol2qm74	7831	15	and	and	CC
cord-015021-pol2qm74	7831	16	ischemia	ischemia	NN
cord-015021-pol2qm74	7831	17	-	-	HYPH
cord-015021-pol2qm74	7831	18	reperfusion	reperfusion	NN
cord-015021-pol2qm74	7831	19	injuries	injury	NNS
cord-015021-pol2qm74	7831	20	such	such	JJ
cord-015021-pol2qm74	7831	21	as	as	IN
cord-015021-pol2qm74	7831	22	arthritis	arthritis	NN
cord-015021-pol2qm74	7831	23	,	,	,
cord-015021-pol2qm74	7831	24	bums	bum	NNS
cord-015021-pol2qm74	7831	25	,	,	,
cord-015021-pol2qm74	7831	26	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	7831	27	shock	shock	NN
cord-015021-pol2qm74	7831	28	,	,	,
cord-015021-pol2qm74	7831	29	bacterial	bacterial	JJ
cord-015021-pol2qm74	7831	30	meningitis	meningitis	NN
cord-015021-pol2qm74	7831	31	,	,	,
cord-015021-pol2qm74	7831	32	autoimmune	autoimmune	JJ
cord-015021-pol2qm74	7831	33	diabetes	diabetes	NN
cord-015021-pol2qm74	7831	34	,	,	,
cord-015021-pol2qm74	7831	35	nerve	nerve	JJ
cord-015021-pol2qm74	7831	36	degeneration	degeneration	NN
cord-015021-pol2qm74	7831	37	,	,	,
cord-015021-pol2qm74	7831	38	allograft	allograft	NN
cord-015021-pol2qm74	7831	39	rejection	rejection	NN
cord-015021-pol2qm74	7831	40	,	,	,
cord-015021-pol2qm74	7831	41	allergic	allergic	JJ
cord-015021-pol2qm74	7831	42	asthma	asthma	NN
cord-015021-pol2qm74	7831	43	,	,	,
cord-015021-pol2qm74	7831	44	acute	acute	JJ
cord-015021-pol2qm74	7831	45	lung	lung	NN
cord-015021-pol2qm74	7831	46	inflammation	inflammation	NN
cord-015021-pol2qm74	7831	47	,	,	,
cord-015021-pol2qm74	7831	48	skin	skin	NN
cord-015021-pol2qm74	7831	49	lesions	lesion	NNS
cord-015021-pol2qm74	7831	50	,	,	,
cord-015021-pol2qm74	7831	51	and	and	CC
cord-015021-pol2qm74	7831	52	ischemia	ischemia	NN
cord-015021-pol2qm74	7831	53	-	-	HYPH
cord-015021-pol2qm74	7831	54	reperfusion	reperfusion	NN
cord-015021-pol2qm74	7831	55	models	model	NNS
cord-015021-pol2qm74	7831	56	of	of	IN
cord-015021-pol2qm74	7831	57	the	the	DT
cord-015021-pol2qm74	7831	58	intestine	intestine	NN
cord-015021-pol2qm74	7831	59	,	,	,
cord-015021-pol2qm74	7831	60	myocardium	myocardium	NN
cord-015021-pol2qm74	7831	61	,	,	,
cord-015021-pol2qm74	7831	62	lung	lung	NN
cord-015021-pol2qm74	7831	63	,	,	,
cord-015021-pol2qm74	7831	64	skeletal	skeletal	JJ
cord-015021-pol2qm74	7831	65	muscle	muscle	NN
cord-015021-pol2qm74	7831	66	,	,	,
cord-015021-pol2qm74	7831	67	and	and	CC
cord-015021-pol2qm74	7831	68	central	central	JJ
cord-015021-pol2qm74	7831	69	nervous	nervous	JJ
cord-015021-pol2qm74	7831	70	system	system	NN
cord-015021-pol2qm74	7831	71	.	.	.
cord-015021-pol2qm74	7832	1	Protective	protective	JJ
cord-015021-pol2qm74	7832	2	effects	effect	NNS
cord-015021-pol2qm74	7832	3	have	have	VBP
cord-015021-pol2qm74	7832	4	also	also	RB
cord-015021-pol2qm74	7832	5	been	be	VBN
cord-015021-pol2qm74	7832	6	observed	observe	VBN
cord-015021-pol2qm74	7832	7	in	in	IN
cord-015021-pol2qm74	7832	8	animals	animal	NNS
cord-015021-pol2qm74	7832	9	resuscitated	resuscitate	VBD
cord-015021-pol2qm74	7832	10	following	follow	VBG
cord-015021-pol2qm74	7832	11	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	7832	12	shock	shock	NN
cord-015021-pol2qm74	7832	13	.	.	.
cord-015021-pol2qm74	7833	1	Since	since	IN
cord-015021-pol2qm74	7833	2	modulating	modulate	VBG
cord-015021-pol2qm74	7833	3	the	the	DT
cord-015021-pol2qm74	7833	4	function	function	NN
cord-015021-pol2qm74	7833	5	of	of	IN
cord-015021-pol2qm74	7833	6	adhesion	adhesion	NN
cord-015021-pol2qm74	7833	7	molecules	molecule	NNS
cord-015021-pol2qm74	7833	8	may	may	MD
cord-015021-pol2qm74	7833	9	temporarily	temporarily	RB
cord-015021-pol2qm74	7833	10	leave	leave	VB
cord-015021-pol2qm74	7833	11	the	the	DT
cord-015021-pol2qm74	7833	12	host	host	NN
cord-015021-pol2qm74	7833	13	without	without	IN
cord-015021-pol2qm74	7833	14	effective	effective	JJ
cord-015021-pol2qm74	7833	15	defense	defense	NN
cord-015021-pol2qm74	7833	16	machinery	machinery	NN
cord-015021-pol2qm74	7833	17	,	,	,
cord-015021-pol2qm74	7833	18	safety	safety	NN
cord-015021-pol2qm74	7833	19	evaluations	evaluation	NNS
cord-015021-pol2qm74	7833	20	are	be	VBP
cord-015021-pol2qm74	7833	21	of	of	IN
cord-015021-pol2qm74	7833	22	utmost	utmost	JJ
cord-015021-pol2qm74	7833	23	importance	importance	NN
cord-015021-pol2qm74	7833	24	in	in	IN
cord-015021-pol2qm74	7833	25	evaluating	evaluate	VBG
cord-015021-pol2qm74	7833	26	this	this	DT
cord-015021-pol2qm74	7833	27	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7833	28	approach	approach	NN
cord-015021-pol2qm74	7833	29	.	.	.
cord-015021-pol2qm74	7834	1	Treatment	treatment	NN
cord-015021-pol2qm74	7834	2	of	of	IN
cord-015021-pol2qm74	7834	3	Gram	gram	NN
cord-015021-pol2qm74	7834	4	-	-	HYPH
cord-015021-pol2qm74	7834	5	negative	negative	JJ
cord-015021-pol2qm74	7834	6	septic	septic	JJ
cord-015021-pol2qm74	7834	7	shock	shock	NN
cord-015021-pol2qm74	7834	8	with	with	IN
cord-015021-pol2qm74	7834	9	an	an	DT
cord-015021-pol2qm74	7834	10	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	7834	11	preparation	preparation	NN
cord-015021-pol2qm74	7834	12	:	:	:
cord-015021-pol2qm74	7835	1	A	a	DT
cord-015021-pol2qm74	7835	2	prospective	prospective	JJ
cord-015021-pol2qm74	7835	3	,	,	,
cord-015021-pol2qm74	7835	4	randomized	randomized	JJ
cord-015021-pol2qm74	7835	5	clinical	clinical	JJ
cord-015021-pol2qm74	7835	6	trial	trial	NN
cord-015021-pol2qm74	7835	7	INGOLF	INGOLF	NNP
cord-015021-pol2qm74	7835	8	SCHEDEL	SCHEDEL	NNP
cord-015021-pol2qm74	7835	9	,	,	,
cord-015021-pol2qm74	7835	10	URSULA	URSULA	NNP
cord-015021-pol2qm74	7835	11	DREIKHAUSEN	DREIKHAUSEN	NNP
cord-015021-pol2qm74	7835	12	;	;	:
cord-015021-pol2qm74	7835	13	BIRGIT	BIRGIT	NNP
cord-015021-pol2qm74	7835	14	NENTWIG	NENTWIG	NNP
cord-015021-pol2qm74	7835	15	;	;	:
cord-015021-pol2qm74	7835	16	MARION	MARION	NNP
cord-015021-pol2qm74	7835	17	HOCKENSCHNtEDER	HOCKENSCHNtEDER	NNP
cord-015021-pol2qm74	7835	18	,	,	,
cord-015021-pol2qm74	7835	19	DIRK	DIRK	NNP
cord-015021-pol2qm74	7835	20	RAUTHMANN	RAUTHMANN	NNP
cord-015021-pol2qm74	7835	21	,	,	,
cord-015021-pol2qm74	7835	22	SALIM	SALIM	NNP
cord-015021-pol2qm74	7835	23	BALIKCIOGLU	BALIKCIOGLU	NNP
cord-015021-pol2qm74	7835	24	,	,	,
cord-015021-pol2qm74	7835	25	ROLF	ROLF	NNP
cord-015021-pol2qm74	7835	26	COLDEWEy	COLDEWEy	NNP
cord-015021-pol2qm74	7835	27	,	,	,
cord-015021-pol2qm74	7835	28	HELMUTH	HELMUTH	NNP
cord-015021-pol2qm74	7835	29	DEICHER	DEICHER	NNP
cord-015021-pol2qm74	7835	30	,	,	,
cord-015021-pol2qm74	7835	31	MD	MD	NNP
cord-015021-pol2qm74	7835	32	Endotoxin	Endotoxin	NNP
cord-015021-pol2qm74	7835	33	may	may	MD
cord-015021-pol2qm74	7835	34	play	play	VB
cord-015021-pol2qm74	7835	35	a	a	DT
cord-015021-pol2qm74	7835	36	major	major	JJ
cord-015021-pol2qm74	7835	37	role	role	NN
cord-015021-pol2qm74	7835	38	in	in	IN
cord-015021-pol2qm74	7835	39	the	the	DT
cord-015021-pol2qm74	7835	40	pathogenesls	pathogenesls	NN
cord-015021-pol2qm74	7835	41	of	of	IN
cord-015021-pol2qm74	7835	42	muitiorgan	muitiorgan	NNP
cord-015021-pol2qm74	7835	43	failure	failure	NN
cord-015021-pol2qm74	7835	44	in	in	IN
cord-015021-pol2qm74	7835	45	the	the	DT
cord-015021-pol2qm74	7835	46	context	context	NN
cord-015021-pol2qm74	7835	47	of	of	IN
cord-015021-pol2qm74	7835	48	the	the	DT
cord-015021-pol2qm74	7835	49	toxic	toxic	JJ
cord-015021-pol2qm74	7835	50	process	process	NN
cord-015021-pol2qm74	7835	51	in	in	IN
cord-015021-pol2qm74	7835	52	septicemia	septicemia	NN
cord-015021-pol2qm74	7835	53	induced	induce	VBN
cord-015021-pol2qm74	7835	54	by	by	IN
cord-015021-pol2qm74	7835	55	gram	gram	NN
cord-015021-pol2qm74	7835	56	-	-	HYPH
cord-015021-pol2qm74	7835	57	negative	negative	JJ
cord-015021-pol2qm74	7835	58	pathogens	pathogen	NNS
cord-015021-pol2qm74	7835	59	.	.	.
cord-015021-pol2qm74	7836	1	The	the	DT
cord-015021-pol2qm74	7836	2	hypothesis	hypothesis	NN
cord-015021-pol2qm74	7836	3	which	which	WDT
cord-015021-pol2qm74	7836	4	has	have	VBZ
cord-015021-pol2qm74	7836	5	led	lead	VBN
cord-015021-pol2qm74	7836	6	to	to	IN
cord-015021-pol2qm74	7836	7	a	a	DT
cord-015021-pol2qm74	7836	8	prospective	prospective	JJ
cord-015021-pol2qm74	7836	9	clinical	clinical	JJ
cord-015021-pol2qm74	7836	10	study	study	NN
cord-015021-pol2qm74	7836	11	consisted	consist	VBD
cord-015021-pol2qm74	7836	12	in	in	IN
cord-015021-pol2qm74	7836	13	the	the	DT
cord-015021-pol2qm74	7836	14	idea	idea	NN
cord-015021-pol2qm74	7836	15	of	of	IN
cord-015021-pol2qm74	7836	16	inhibiting	inhibit	VBG
cord-015021-pol2qm74	7836	17	the	the	DT
cord-015021-pol2qm74	7836	18	biological	biological	JJ
cord-015021-pol2qm74	7836	19	effects	effect	NNS
cord-015021-pol2qm74	7836	20	ofendotoxin	ofendotoxin	RB
cord-015021-pol2qm74	7836	21	during	during	IN
cord-015021-pol2qm74	7836	22	the	the	DT
cord-015021-pol2qm74	7836	23	early	early	JJ
cord-015021-pol2qm74	7836	24	phase	phase	NN
cord-015021-pol2qm74	7836	25	of	of	IN
cord-015021-pol2qm74	7836	26	septic	septic	JJ
cord-015021-pol2qm74	7836	27	process	process	NN
cord-015021-pol2qm74	7836	28	,	,	,
cord-015021-pol2qm74	7836	29	and	and	CC
cord-015021-pol2qm74	7836	30	thereby	thereby	RB
cord-015021-pol2qm74	7836	31	attampting	attampte	VBG
cord-015021-pol2qm74	7836	32	to	to	TO
cord-015021-pol2qm74	7836	33	attain	attain	VB
cord-015021-pol2qm74	7836	34	a	a	DT
cord-015021-pol2qm74	7836	35	positive	positive	JJ
cord-015021-pol2qm74	7836	36	effect	effect	NN
cord-015021-pol2qm74	7836	37	on	on	IN
cord-015021-pol2qm74	7836	38	the	the	DT
cord-015021-pol2qm74	7836	39	clinical	clinical	JJ
cord-015021-pol2qm74	7836	40	course	course	NN
cord-015021-pol2qm74	7836	41	of	of	IN
cord-015021-pol2qm74	7836	42	the	the	DT
cord-015021-pol2qm74	7836	43	disease	disease	NN
cord-015021-pol2qm74	7836	44	.	.	.
cord-015021-pol2qm74	7837	1	-Objecave	-Objecave	VBZ
cord-015021-pol2qm74	7837	2	:	:	:
cord-015021-pol2qm74	7837	3	To	to	TO
cord-015021-pol2qm74	7837	4	evaluate	evaluate	VB
cord-015021-pol2qm74	7837	5	the	the	DT
cord-015021-pol2qm74	7837	6	effectiveness	effectiveness	NN
cord-015021-pol2qm74	7837	7	ofa	ofa	NN
cord-015021-pol2qm74	7837	8	polyclonal	polyclonal	JJ
cord-015021-pol2qm74	7837	9	immunoglobulln	immunoglobulln	NN
cord-015021-pol2qm74	7837	10	(	(	-LRB-
cord-015021-pol2qm74	7837	11	Ig	Ig	NNP
cord-015021-pol2qm74	7837	12	)	)	-RRB-
cord-015021-pol2qm74	7837	13	preparation	preparation	NN
cord-015021-pol2qm74	7837	14	containing	contain	VBG
cord-015021-pol2qm74	7837	15	IgG	IgG	NNP
cord-015021-pol2qm74	7837	16	,	,	,
cord-015021-pol2qm74	7837	17	lgM	lgM	NNP
cord-015021-pol2qm74	7837	18	,	,	,
cord-015021-pol2qm74	7837	19	and	and	CC
cord-015021-pol2qm74	7837	20	IgA	IgA	NNP
cord-015021-pol2qm74	7837	21	as	as	IN
cord-015021-pol2qm74	7837	22	an	an	DT
cord-015021-pol2qm74	7837	23	adjunctive	adjunctive	JJ
cord-015021-pol2qm74	7837	24	therapy	therapy	NN
cord-015021-pol2qm74	7837	25	for	for	IN
cord-015021-pol2qm74	7837	26	septic	septic	JJ
cord-015021-pol2qm74	7837	27	shock	shock	NN
cord-015021-pol2qm74	7837	28	.	.	.
cord-015021-pol2qm74	7838	1	-Desigru	-Desigru	:
cord-015021-pol2qm74	7838	2	Prospective	prospective	JJ
cord-015021-pol2qm74	7838	3	,	,	,
cord-015021-pol2qm74	7838	4	randomized	randomized	JJ
cord-015021-pol2qm74	7838	5	clinical	clinical	JJ
cord-015021-pol2qm74	7838	6	trial	trial	NN
cord-015021-pol2qm74	7838	7	.	.	.
cord-015021-pol2qm74	7839	1	Patients	patient	NNS
cord-015021-pol2qm74	7839	2	:	:	:
cord-015021-pol2qm74	7840	1	Fifty	fifty	CD
cord-015021-pol2qm74	7840	2	-	-	HYPH
cord-015021-pol2qm74	7840	3	five	five	CD
cord-015021-pol2qm74	7840	4	patients	patient	NNS
cord-015021-pol2qm74	7840	5	w	w	IN
cord-015021-pol2qm74	7840	6	~	~	CD
cord-015021-pol2qm74	7840	7	th	th	DT
cord-015021-pol2qm74	7840	8	septic	septic	JJ
cord-015021-pol2qm74	7840	9	shock	shock	NN
cord-015021-pol2qm74	7840	10	were	be	VBD
cord-015021-pol2qm74	7840	11	randomly	randomly	RB
cord-015021-pol2qm74	7840	12	allocated	allocate	VBN
cord-015021-pol2qm74	7840	13	to	to	IN
cord-015021-pol2qm74	7840	14	two	two	CD
cord-015021-pol2qm74	7840	15	groups	group	NNS
cord-015021-pol2qm74	7840	16	according	accord	VBG
cord-015021-pol2qm74	7840	17	to	to	IN
cord-015021-pol2qm74	7840	18	criteria	criterion	NNS
cord-015021-pol2qm74	7840	19	of	of	IN
cord-015021-pol2qm74	7840	20	septic	septic	JJ
cord-015021-pol2qm74	7840	21	shock	shock	NN
cord-015021-pol2qm74	7840	22	.	.	.
cord-015021-pol2qm74	7841	1	-Intervention	-intervention	NN
cord-015021-pol2qm74	7841	2	:	:	:
cord-015021-pol2qm74	7841	3	One	one	CD
cord-015021-pol2qm74	7841	4	group	group	NN
cord-015021-pol2qm74	7841	5	of	of	IN
cord-015021-pol2qm74	7841	6	patients	patient	NNS
cord-015021-pol2qm74	7841	7	(	(	-LRB-
cord-015021-pol2qm74	7841	8	n	n	NN
cord-015021-pol2qm74	7841	9	=	=	SYM
cord-015021-pol2qm74	7841	10	27	27	CD
cord-015021-pol2qm74	7841	11	)	)	-RRB-
cord-015021-pol2qm74	7841	12	received	receive	VBD
cord-015021-pol2qm74	7841	13	a	a	DT
cord-015021-pol2qm74	7841	14	commercially	commercially	RB
cord-015021-pol2qm74	7841	15	available	available	JJ
cord-015021-pol2qm74	7841	16	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	7841	17	preparation	preparation	NN
cord-015021-pol2qm74	7841	18	(	(	-LRB-
cord-015021-pol2qm74	7841	19	containing	contain	VBG
cord-015021-pol2qm74	7841	20	high	high	JJ
cord-015021-pol2qm74	7841	21	titers	titer	NNS
cord-015021-pol2qm74	7841	22	of	of	IN
cord-015021-pol2qm74	7841	23	antibodies	antibody	NNS
cord-015021-pol2qm74	7841	24	specific	specific	JJ
cord-015021-pol2qm74	7841	25	for	for	IN
cord-015021-pol2qm74	7841	26	determinants	determinant	NNS
cord-015021-pol2qm74	7841	27	to	to	IN
cord-015021-pol2qm74	7841	28	bacteria1	bacteria1	NN
cord-015021-pol2qm74	7841	29	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7841	30	)	)	-RRB-
cord-015021-pol2qm74	7841	31	during	during	IN
cord-015021-pol2qm74	7841	32	the	the	DT
cord-015021-pol2qm74	7841	33	first	first	JJ
cord-015021-pol2qm74	7841	34	3	3	CD
cord-015021-pol2qm74	7841	35	days	day	NNS
cord-015021-pol2qm74	7841	36	after	after	IN
cord-015021-pol2qm74	7841	37	incIosion	inciosion	NN
cord-015021-pol2qm74	7841	38	in	in	IN
cord-015021-pol2qm74	7841	39	the	the	DT
cord-015021-pol2qm74	7841	40	study	study	NN
cord-015021-pol2qm74	7841	41	.	.	.
cord-015021-pol2qm74	7842	1	The	the	DT
cord-015021-pol2qm74	7842	2	other	other	JJ
cord-015021-pol2qm74	7842	3	randomized	randomized	JJ
cord-015021-pol2qm74	7842	4	group	group	NN
cord-015021-pol2qm74	7842	5	(	(	-LRB-
cord-015021-pol2qm74	7842	6	n	n	NN
cord-015021-pol2qm74	7842	7	=	=	SYM
cord-015021-pol2qm74	7842	8	28	28	CD
cord-015021-pol2qm74	7842	9	)	)	-RRB-
cord-015021-pol2qm74	7842	10	did	do	VBD
cord-015021-pol2qm74	7842	11	not	not	RB
cord-015021-pol2qm74	7842	12	receive	receive	VB
cord-015021-pol2qm74	7842	13	any	any	DT
cord-015021-pol2qm74	7842	14	immunogiobulin	immunogiobulin	NNP
cord-015021-pol2qm74	7842	15	preparation	preparation	NN
cord-015021-pol2qm74	7842	16	.	.	.
cord-015021-pol2qm74	7843	1	-Measuremems	-measuremem	NNS
cord-015021-pol2qm74	7844	1	and	and	CC
cord-015021-pol2qm74	7844	2	Main	Main	NNP
cord-015021-pol2qm74	7844	3	ResMts	ResMts	NNP
cord-015021-pol2qm74	7844	4	:	:	:
cord-015021-pol2qm74	7844	5	During	during	IN
cord-015021-pol2qm74	7844	6	the	the	DT
cord-015021-pol2qm74	7844	7	period	period	NN
cord-015021-pol2qm74	7844	8	of	of	IN
cord-015021-pol2qm74	7844	9	<	<	NNP
cord-015021-pol2qm74	7844	10	6	6	CD
cord-015021-pol2qm74	7844	11	wks	wk	NNS
cord-015021-pol2qm74	7844	12	after	after	IN
cord-015021-pol2qm74	7844	13	the	the	DT
cord-015021-pol2qm74	7844	14	beginning	beginning	NN
cord-015021-pol2qm74	7844	15	of	of	IN
cord-015021-pol2qm74	7844	16	clinically	clinically	RB
cord-015021-pol2qm74	7844	17	apparent	apparent	JJ
cord-015021-pol2qm74	7844	18	septic	septic	JJ
cord-015021-pol2qm74	7844	19	shock	shock	NN
cord-015021-pol2qm74	7844	20	,	,	,
cord-015021-pol2qm74	7844	21	death	death	NN
cord-015021-pol2qm74	7844	22	related	relate	VBN
cord-015021-pol2qm74	7844	23	to	to	IN
cord-015021-pol2qm74	7844	24	the	the	DT
cord-015021-pol2qm74	7844	25	septic	septic	JJ
cord-015021-pol2qm74	7844	26	process	process	NN
cord-015021-pol2qm74	7844	27	occurred	occur	VBD
cord-015021-pol2qm74	7844	28	in	in	IN
cord-015021-pol2qm74	7844	29	one	one	CD
cord-015021-pol2qm74	7844	30	(	(	-LRB-
cord-015021-pol2qm74	7844	31	4	4	CD
cord-015021-pol2qm74	7844	32	%	%	NN
cord-015021-pol2qm74	7844	33	)	)	-RRB-
cord-015021-pol2qm74	7844	34	of	of	IN
cord-015021-pol2qm74	7844	35	27	27	CD
cord-015021-pol2qm74	7844	36	patients	patient	NNS
cord-015021-pol2qm74	7844	37	who	who	WP
cord-015021-pol2qm74	7844	38	received	receive	VBD
cord-015021-pol2qm74	7844	39	immunoglobulln	immunoglobulln	NN
cord-015021-pol2qm74	7844	40	.	.	.
cord-015021-pol2qm74	7845	1	By	by	IN
cord-015021-pol2qm74	7845	2	comparison	comparison	NN
cord-015021-pol2qm74	7845	3	,	,	,
cord-015021-pol2qm74	7845	4	nine	nine	CD
cord-015021-pol2qm74	7845	5	(	(	-LRB-
cord-015021-pol2qm74	7845	6	32	32	CD
cord-015021-pol2qm74	7845	7	%	%	NN
cord-015021-pol2qm74	7845	8	)	)	-RRB-
cord-015021-pol2qm74	7845	9	of	of	IN
cord-015021-pol2qm74	7845	10	28	28	CD
cord-015021-pol2qm74	7845	11	control	control	NN
cord-015021-pol2qm74	7845	12	group	group	NN
cord-015021-pol2qm74	7845	13	patients	patient	NNS
cord-015021-pol2qm74	7845	14	died	die	VBD
cord-015021-pol2qm74	7845	15	during	during	IN
cord-015021-pol2qm74	7845	16	this	this	DT
cord-015021-pol2qm74	7845	17	period	period	NN
cord-015021-pol2qm74	7845	18	(	(	-LRB-
cord-015021-pol2qm74	7845	19	p	p	NN
cord-015021-pol2qm74	7845	20	<	<	XX
cord-015021-pol2qm74	7845	21	.	.	.
cord-015021-pol2qm74	7845	22	01	01	CD
cord-015021-pol2qm74	7845	23	)	)	-RRB-
cord-015021-pol2qm74	7845	24	.	.	.
cord-015021-pol2qm74	7846	1	Within	within	IN
cord-015021-pol2qm74	7846	2	the	the	DT
cord-015021-pol2qm74	7846	3	first	first	JJ
cord-015021-pol2qm74	7846	4	48	48	CD
cord-015021-pol2qm74	7846	5	hrs	hrs	NN
cord-015021-pol2qm74	7846	6	after	after	IN
cord-015021-pol2qm74	7846	7	onset	onset	NN
cord-015021-pol2qm74	7846	8	of	of	IN
cord-015021-pol2qm74	7846	9	the	the	DT
cord-015021-pol2qm74	7846	10	clinically	clinically	RB
cord-015021-pol2qm74	7846	11	apparent	apparent	JJ
cord-015021-pol2qm74	7846	12	septie	septie	NN
cord-015021-pol2qm74	7846	13	process	process	NN
cord-015021-pol2qm74	7846	14	,	,	,
cord-015021-pol2qm74	7846	15	significaptly	significaptly	RB
cord-015021-pol2qm74	7846	16	increased	increase	VBN
cord-015021-pol2qm74	7846	17	activity	activity	NN
cord-015021-pol2qm74	7846	18	of	of	IN
cord-015021-pol2qm74	7846	19	circulating	circulate	VBG
cord-015021-pol2qm74	7846	20	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7846	21	and	and	CC
cord-015021-pol2qm74	7846	22	simultaneously	simultaneously	RB
cord-015021-pol2qm74	7846	23	decreased	decrease	VBD
cord-015021-pol2qm74	7846	24	specifie	specifie	NN
cord-015021-pol2qm74	7846	25	IgG	IgG	NNP
cord-015021-pol2qm74	7846	26	serum	serum	NN
cord-015021-pol2qm74	7846	27	titers	titer	NNS
cord-015021-pol2qm74	7846	28	to	to	TO
cord-015021-pol2qm74	7846	29	lipid	lipid	VB
cord-015021-pol2qm74	7846	30	A	a	DT
cord-015021-pol2qm74	7846	31	were	be	VBD
cord-015021-pol2qm74	7846	32	detected	detect	VBN
cord-015021-pol2qm74	7846	33	in	in	IN
cord-015021-pol2qm74	7846	34	the	the	DT
cord-015021-pol2qm74	7846	35	group	group	NN
cord-015021-pol2qm74	7846	36	of	of	IN
cord-015021-pol2qm74	7846	37	nonsurvivors	nonsurvivors	NNP
cord-015021-pol2qm74	7846	38	.	.	.
cord-015021-pol2qm74	7847	1	The	the	DT
cord-015021-pol2qm74	7847	2	rationale	rationale	NN
cord-015021-pol2qm74	7847	3	for	for	IN
cord-015021-pol2qm74	7847	4	the	the	DT
cord-015021-pol2qm74	7847	5	use	use	NN
cord-015021-pol2qm74	7847	6	of	of	IN
cord-015021-pol2qm74	7847	7	polyvalent	polyvalent	JJ
cord-015021-pol2qm74	7847	8	intravenous	intravenous	JJ
cord-015021-pol2qm74	7847	9	immunogiobulins	immunogiobulin	NNS
cord-015021-pol2qm74	7847	10	(	(	-LRB-
cord-015021-pol2qm74	7847	11	IVIG	IVIG	NNP
cord-015021-pol2qm74	7847	12	)	)	-RRB-
cord-015021-pol2qm74	7847	13	to	to	TO
cord-015021-pol2qm74	7847	14	treat	treat	VB
cord-015021-pol2qm74	7847	15	severe	severe	JJ
cord-015021-pol2qm74	7847	16	infections	infection	NNS
cord-015021-pol2qm74	7847	17	stems	stem	VBZ
cord-015021-pol2qm74	7847	18	from	from	IN
cord-015021-pol2qm74	7847	19	in	in	IN
cord-015021-pol2qm74	7847	20	vitro	vitro	FW
cord-015021-pol2qm74	7847	21	and	and	CC
cord-015021-pol2qm74	7847	22	animal	animal	NN
cord-015021-pol2qm74	7847	23	studies	study	NNS
cord-015021-pol2qm74	7847	24	documenting	document	VBG
cord-015021-pol2qm74	7847	25	that	that	IN
cord-015021-pol2qm74	7847	26	high	high	JJ
cord-015021-pol2qm74	7847	27	-	-	HYPH
cord-015021-pol2qm74	7847	28	dose	dose	NN
cord-015021-pol2qm74	7847	29	IgG	igg	NN
cord-015021-pol2qm74	7847	30	enhance	enhance	VB
cord-015021-pol2qm74	7847	31	opsonization	opsonization	NN
cord-015021-pol2qm74	7847	32	and	and	CC
cord-015021-pol2qm74	7847	33	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7847	34	of	of	IN
cord-015021-pol2qm74	7847	35	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	7847	36	bacteria	bacteria	NNS
cord-015021-pol2qm74	7847	37	.	.	.
cord-015021-pol2qm74	7848	1	Moreover	moreover	RB
cord-015021-pol2qm74	7848	2	,	,	,
cord-015021-pol2qm74	7848	3	recent	recent	JJ
cord-015021-pol2qm74	7848	4	clinical	clinical	JJ
cord-015021-pol2qm74	7848	5	studies	study	NNS
cord-015021-pol2qm74	7848	6	have	have	VBP
cord-015021-pol2qm74	7848	7	shown	show	VBN
cord-015021-pol2qm74	7848	8	that	that	IN
cord-015021-pol2qm74	7848	9	in	in	IN
cord-015021-pol2qm74	7848	10	septic	septic	JJ
cord-015021-pol2qm74	7848	11	patients	patient	NNS
cord-015021-pol2qm74	7848	12	the	the	DT
cord-015021-pol2qm74	7848	13	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7848	14	function	function	NN
cord-015021-pol2qm74	7848	15	of	of	IN
cord-015021-pol2qm74	7848	16	circulating	circulate	VBG
cord-015021-pol2qm74	7848	17	polymorphonuclear	polymorphonuclear	JJ
cord-015021-pol2qm74	7848	18	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	7848	19	(	(	-LRB-
cord-015021-pol2qm74	7848	20	PMN	PMN	NNP
cord-015021-pol2qm74	7848	21	)	)	-RRB-
cord-015021-pol2qm74	7848	22	is	be	VBZ
cord-015021-pol2qm74	7848	23	defective	defective	JJ
cord-015021-pol2qm74	7848	24	;	;	:
cord-015021-pol2qm74	7848	25	the	the	DT
cord-015021-pol2qm74	7848	26	degree	degree	NN
cord-015021-pol2qm74	7848	27	of	of	IN
cord-015021-pol2qm74	7848	28	such	such	JJ
cord-015021-pol2qm74	7848	29	impairment	impairment	NN
cord-015021-pol2qm74	7848	30	correlates	correlate	VBZ
cord-015021-pol2qm74	7848	31	to	to	IN
cord-015021-pol2qm74	7848	32	the	the	DT
cord-015021-pol2qm74	7848	33	severity	severity	NN
cord-015021-pol2qm74	7848	34	of	of	IN
cord-015021-pol2qm74	7848	35	the	the	DT
cord-015021-pol2qm74	7848	36	septic	septic	JJ
cord-015021-pol2qm74	7848	37	state	state	NN
cord-015021-pol2qm74	7849	1	,	,	,
cord-015021-pol2qm74	7849	2	The	the	DT
cord-015021-pol2qm74	7849	3	beneficial	beneficial	JJ
cord-015021-pol2qm74	7849	4	effect	effect	NN
cord-015021-pol2qm74	7849	5	of	of	IN
cord-015021-pol2qm74	7849	6	administering	administer	VBG
cord-015021-pol2qm74	7849	7	high	high	JJ
cord-015021-pol2qm74	7849	8	dose	dose	NN
cord-015021-pol2qm74	7849	9	IgO	igo	NN
cord-015021-pol2qm74	7849	10	in	in	IN
cord-015021-pol2qm74	7849	11	septic	septic	JJ
cord-015021-pol2qm74	7849	12	patients	patient	NNS
cord-015021-pol2qm74	7849	13	can	can	MD
cord-015021-pol2qm74	7849	14	be	be	VB
cord-015021-pol2qm74	7850	1	two	two	LS
cord-015021-pol2qm74	7850	2	-	-	HYPH
cord-015021-pol2qm74	7850	3	fold	fold	RB
cord-015021-pol2qm74	7850	4	:	:	:
cord-015021-pol2qm74	7850	5	I	i	NN
cord-015021-pol2qm74	7850	6	)	)	-RRB-
cord-015021-pol2qm74	7850	7	IVIG	IVIG	NNP
cord-015021-pol2qm74	7850	8	provides	provide	VBZ
cord-015021-pol2qm74	7850	9	large	large	JJ
cord-015021-pol2qm74	7850	10	quantities	quantity	NNS
cord-015021-pol2qm74	7850	11	of	of	IN
cord-015021-pol2qm74	7850	12	antibodies	antibody	NNS
cord-015021-pol2qm74	7850	13	against	against	IN
cord-015021-pol2qm74	7850	14	invading	invade	VBG
cord-015021-pol2qm74	7850	15	pathogens	pathogen	NNS
cord-015021-pol2qm74	7850	16	;	;	:
cord-015021-pol2qm74	7850	17	the	the	DT
cord-015021-pol2qm74	7850	18	IgG	igg	NN
cord-015021-pol2qm74	7850	19	bound	bind	VBN
cord-015021-pol2qm74	7850	20	to	to	IN
cord-015021-pol2qm74	7850	21	the	the	DT
cord-015021-pol2qm74	7850	22	pathogens	pathogen	NNS
cord-015021-pol2qm74	7850	23	can	can	MD
cord-015021-pol2qm74	7850	24	opsonize	opsonize	VB
cord-015021-pol2qm74	7850	25	their	-PRON-	PRP$
cord-015021-pol2qm74	7850	26	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7850	27	;	;	:
cord-015021-pol2qm74	7850	28	2	2	LS
cord-015021-pol2qm74	7850	29	)	)	-RRB-
cord-015021-pol2qm74	7850	30	the	the	DT
cord-015021-pol2qm74	7850	31	opsonization	opsonization	NN
cord-015021-pol2qm74	7850	32	of	of	IN
cord-015021-pol2qm74	7850	33	phagocytosis	phagocytosis	NN
cord-015021-pol2qm74	7850	34	by	by	IN
cord-015021-pol2qm74	7850	35	exogenously	exogenously	RB
cord-015021-pol2qm74	7850	36	administred	administre	VBN
cord-015021-pol2qm74	7850	37	polyvalent	polyvalent	JJ
cord-015021-pol2qm74	7850	38	IgO	igo	NN
cord-015021-pol2qm74	7850	39	would	would	MD
cord-015021-pol2qm74	7850	40	be	be	VB
cord-015021-pol2qm74	7850	41	of	of	IN
cord-015021-pol2qm74	7850	42	special	special	JJ
cord-015021-pol2qm74	7850	43	importance	importance	NN
cord-015021-pol2qm74	7850	44	in	in	IN
cord-015021-pol2qm74	7850	45	those	those	DT
cord-015021-pol2qm74	7850	46	patients	patient	NNS
cord-015021-pol2qm74	7850	47	who	who	WP
cord-015021-pol2qm74	7850	48	present	present	VBP
cord-015021-pol2qm74	7850	49	a	a	DT
cord-015021-pol2qm74	7850	50	significant	significant	JJ
cord-015021-pol2qm74	7850	51	defect	defect	NN
cord-015021-pol2qm74	7850	52	of	of	IN
cord-015021-pol2qm74	7850	53	their	-PRON-	PRP$
cord-015021-pol2qm74	7850	54	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	7850	55	function	function	NN
cord-015021-pol2qm74	7850	56	,	,	,
cord-015021-pol2qm74	7850	57	when	when	WRB
cord-015021-pol2qm74	7850	58	they	-PRON-	PRP
cord-015021-pol2qm74	7850	59	are	be	VBP
cord-015021-pol2qm74	7850	60	challanged	challange	VBN
cord-015021-pol2qm74	7850	61	by	by	IN
cord-015021-pol2qm74	7850	62	a	a	DT
cord-015021-pol2qm74	7850	63	large	large	JJ
cord-015021-pol2qm74	7850	64	bacterial	bacterial	JJ
cord-015021-pol2qm74	7850	65	invasion	invasion	NN
cord-015021-pol2qm74	7850	66	.	.	.
cord-015021-pol2qm74	7851	1	A	a	DT
cord-015021-pol2qm74	7851	2	prospective	prospective	NN
cord-015021-pol2qm74	7851	3	,	,	,
cord-015021-pol2qm74	7851	4	randomized	randomized	JJ
cord-015021-pol2qm74	7851	5	,	,	,
cord-015021-pol2qm74	7851	6	double	double	JJ
cord-015021-pol2qm74	7851	7	-	-	HYPH
cord-015021-pol2qm74	7851	8	blind	blind	JJ
cord-015021-pol2qm74	7851	9	study	study	NN
cord-015021-pol2qm74	7851	10	was	be	VBD
cord-015021-pol2qm74	7851	11	carried	carry	VBN
cord-015021-pol2qm74	7851	12	out	out	RP
cord-015021-pol2qm74	7851	13	comparing	compare	VBG
cord-015021-pol2qm74	7851	14	the	the	DT
cord-015021-pol2qm74	7851	15	administration	administration	NN
cord-015021-pol2qm74	7851	16	of	of	IN
cord-015021-pol2qm74	7851	17	IVIG	IVIG	NNP
cord-015021-pol2qm74	7851	18	(	(	-LRB-
cord-015021-pol2qm74	7851	19	Sandoglobulin@	sandoglobulin@	NN
cord-015021-pol2qm74	7851	20	)	)	-RRB-
cord-015021-pol2qm74	7851	21	vs	vs	NNP
cord-015021-pol2qm74	7851	22	,	,	,
cord-015021-pol2qm74	7851	23	paeebo	paeebo	NNP
cord-015021-pol2qm74	7851	24	(	(	-LRB-
cord-015021-pol2qm74	7851	25	human	human	JJ
cord-015021-pol2qm74	7851	26	albumin	albumin	NN
cord-015021-pol2qm74	7851	27	)	)	-RRB-
cord-015021-pol2qm74	7851	28	in	in	IN
cord-015021-pol2qm74	7851	29	severely	severely	RB
cord-015021-pol2qm74	7851	30	septic	septic	JJ
cord-015021-pol2qm74	7851	31	surgical	surgical	JJ
cord-015021-pol2qm74	7851	32	patients	patient	NNS
cord-015021-pol2qm74	7851	33	,	,	,
cord-015021-pol2qm74	7851	34	Only	only	RB
cord-015021-pol2qm74	7851	35	patients	patient	NNS
cord-015021-pol2qm74	7851	36	with	with	IN
cord-015021-pol2qm74	7851	37	gepis	gepis	NN
cord-015021-pol2qm74	7851	38	score	score	NN
cord-015021-pol2qm74	7852	1	>	>	XX
cord-015021-pol2qm74	7853	1	_	_	NN
cord-015021-pol2qm74	7853	2	20	20	CD
cord-015021-pol2qm74	7853	3	(	(	-LRB-
cord-015021-pol2qm74	7853	4	meaning	mean	VBG
cord-015021-pol2qm74	7853	5	a	a	DT
cord-015021-pol2qm74	7853	6	mortality	mortality	NN
cord-015021-pol2qm74	7853	7	risk	risk	NN
cord-015021-pol2qm74	7853	8	>	>	XX
cord-015021-pol2qm74	7853	9	70	70	CD
cord-015021-pol2qm74	7853	10	%	%	NN
cord-015021-pol2qm74	7853	11	)	)	-RRB-
cord-015021-pol2qm74	7853	12	were	be	VBD
cord-015021-pol2qm74	7853	13	accepted	accept	VBN
cord-015021-pol2qm74	7853	14	into	into	IN
cord-015021-pol2qm74	7853	15	this	this	DT
cord-015021-pol2qm74	7853	16	protocol	protocol	NN
cord-015021-pol2qm74	7853	17	.	.	.
cord-015021-pol2qm74	7854	1	Patients	patient	NNS
cord-015021-pol2qm74	7854	2	were	be	VBD
cord-015021-pol2qm74	7854	3	randomized	randomize	VBN
cord-015021-pol2qm74	7854	4	to	to	TO
cord-015021-pol2qm74	7854	5	receive	receive	VB
cord-015021-pol2qm74	7854	6	0.4	0.4	CD
cord-015021-pol2qm74	7854	7	g	g	NN
cord-015021-pol2qm74	7854	8	/	/	SYM
cord-015021-pol2qm74	7854	9	Kg	Kg	NNP
cord-015021-pol2qm74	7854	10	of	of	IN
cord-015021-pol2qm74	7854	11	IVIG	IVIG	NNP
cord-015021-pol2qm74	7854	12	or	or	CC
cord-015021-pol2qm74	7854	13	placebo	placebo	NN
cord-015021-pol2qm74	7854	14	on	on	IN
cord-015021-pol2qm74	7854	15	day	day	NN
cord-015021-pol2qm74	7854	16	0	0	NFP
cord-015021-pol2qm74	7854	17	(	(	-LRB-
cord-015021-pol2qm74	7854	18	when	when	WRB
cord-015021-pol2qm74	7854	19	they	-PRON-	PRP
cord-015021-pol2qm74	7854	20	reached	reach	VBD
cord-015021-pol2qm74	7854	21	sepsis	sepsis	NN
cord-015021-pol2qm74	7854	22	score>20	score>20	NNS
cord-015021-pol2qm74	7854	23	)	)	-RRB-
cord-015021-pol2qm74	7854	24	,	,	,
cord-015021-pol2qm74	7854	25	repeated	repeat	VBN
cord-015021-pol2qm74	7854	26	on	on	IN
cord-015021-pol2qm74	7854	27	day	day	NN
cord-015021-pol2qm74	7854	28	+1	+1	NFP
cord-015021-pol2qm74	7854	29	and	and	CC
cord-015021-pol2qm74	7854	30	+5	+5	NN
cord-015021-pol2qm74	7854	31	.	.	.
cord-015021-pol2qm74	7855	1	At	at	IN
cord-015021-pol2qm74	7855	2	the	the	DT
cord-015021-pol2qm74	7855	3	beginning	beginning	NN
cord-015021-pol2qm74	7855	4	of	of	IN
cord-015021-pol2qm74	7855	5	ICU	ICU	NNP
cord-015021-pol2qm74	7855	6	treatment	treatment	NN
cord-015021-pol2qm74	7855	7	,	,	,
cord-015021-pol2qm74	7855	8	the	the	DT
cord-015021-pol2qm74	7855	9	two	two	CD
cord-015021-pol2qm74	7855	10	groups	group	NNS
cord-015021-pol2qm74	7855	11	of	of	IN
cord-015021-pol2qm74	7855	12	patients	patient	NNS
cord-015021-pol2qm74	7855	13	were	be	VBD
cord-015021-pol2qm74	7855	14	similar	similar	JJ
cord-015021-pol2qm74	7855	15	for	for	IN
cord-015021-pol2qm74	7855	16	severity	severity	NN
cord-015021-pol2qm74	7855	17	of	of	IN
cord-015021-pol2qm74	7855	18	sepsis	sepsis	NN
cord-015021-pol2qm74	7855	19	,	,	,
cord-015021-pol2qm74	7855	20	age	age	NN
cord-015021-pol2qm74	7855	21	,	,	,
cord-015021-pol2qm74	7855	22	concomitant	concomitant	JJ
cord-015021-pol2qm74	7855	23	disease	disease	NN
cord-015021-pol2qm74	7855	24	,	,	,
cord-015021-pol2qm74	7855	25	type	type	NN
cord-015021-pol2qm74	7855	26	of	of	IN
cord-015021-pol2qm74	7855	27	surgical	surgical	JJ
cord-015021-pol2qm74	7855	28	procedures	procedure	NNS
cord-015021-pol2qm74	7855	29	,	,	,
cord-015021-pol2qm74	7855	30	antra	antra	NNP
cord-015021-pol2qm74	7855	31	and	and	CC
cord-015021-pol2qm74	7855	32	perioperative	perioperative	JJ
cord-015021-pol2qm74	7855	33	procedures	procedure	NNS
cord-015021-pol2qm74	7855	34	,	,	,
cord-015021-pol2qm74	7855	35	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	7855	36	administration	administration	NN
cord-015021-pol2qm74	7855	37	.	.	.
cord-015021-pol2qm74	7856	1	The	the	DT
cord-015021-pol2qm74	7856	2	results	result	NNS
cord-015021-pol2qm74	7856	3	of	of	IN
cord-015021-pol2qm74	7856	4	the	the	DT
cord-015021-pol2qm74	7856	5	study	study	NN
cord-015021-pol2qm74	7856	6	indicated	indicate	VBD
cord-015021-pol2qm74	7856	7	a	a	DT
cord-015021-pol2qm74	7856	8	significantly	significantly	RB
cord-015021-pol2qm74	7856	9	reduced	reduce	VBN
cord-015021-pol2qm74	7856	10	mortality	mortality	NN
cord-015021-pol2qm74	7856	11	in	in	IN
cord-015021-pol2qm74	7856	12	patients	patient	NNS
cord-015021-pol2qm74	7856	13	with	with	IN
cord-015021-pol2qm74	7856	14	severe	severe	JJ
cord-015021-pol2qm74	7856	15	surgical	surgical	JJ
cord-015021-pol2qm74	7856	16	sepsis	sepsis	NN
cord-015021-pol2qm74	7856	17	treated	treat	VBN
cord-015021-pol2qm74	7856	18	with	with	IN
cord-015021-pol2qm74	7856	19	IVIG	IVIG	NNP
cord-015021-pol2qm74	7856	20	as	as	IN
cord-015021-pol2qm74	7856	21	compared	compare	VBN
cord-015021-pol2qm74	7856	22	to	to	IN
cord-015021-pol2qm74	7856	23	placebo	placebo	NN
cord-015021-pol2qm74	7856	24	control	control	NN
cord-015021-pol2qm74	7856	25	patients	patient	NNS
cord-015021-pol2qm74	7856	26	(	(	-LRB-
cord-015021-pol2qm74	7856	27	mortality	mortality	NN
cord-015021-pol2qm74	7856	28	:	:	:
cord-015021-pol2qm74	7856	29	38	38	CD
cord-015021-pol2qm74	7856	30	%	%	NN
cord-015021-pol2qm74	7856	31	vs	vs	IN
cord-015021-pol2qm74	7856	32	,	,	,
cord-015021-pol2qm74	7856	33	67	67	CD
cord-015021-pol2qm74	7856	34	%	%	NN
cord-015021-pol2qm74	7856	35	respectively	respectively	RB
cord-015021-pol2qm74	7856	36	;	;	.
cord-015021-pol2qm74	7857	1	p	p	NN
cord-015021-pol2qm74	7857	2	<	<	XX
cord-015021-pol2qm74	7857	3	0,05	0,05	NNP
cord-015021-pol2qm74	7857	4	)	)	-RRB-
cord-015021-pol2qm74	7857	5	.	.	.
cord-015021-pol2qm74	7858	1	In	in	IN
cord-015021-pol2qm74	7858	2	conclusion	conclusion	NN
cord-015021-pol2qm74	7858	3	,	,	,
cord-015021-pol2qm74	7858	4	the	the	DT
cord-015021-pol2qm74	7858	5	results	result	NNS
cord-015021-pol2qm74	7858	6	of	of	IN
cord-015021-pol2qm74	7858	7	our	-PRON-	PRP$
cord-015021-pol2qm74	7858	8	study	study	NN
cord-015021-pol2qm74	7858	9	in	in	IN
cord-015021-pol2qm74	7858	10	patients	patient	NNS
cord-015021-pol2qm74	7858	11	with	with	IN
cord-015021-pol2qm74	7858	12	severe	severe	JJ
cord-015021-pol2qm74	7858	13	surgical	surgical	JJ
cord-015021-pol2qm74	7858	14	sepsis	sepsis	NN
cord-015021-pol2qm74	7858	15	were	be	VBD
cord-015021-pol2qm74	7858	16	the	the	DT
cord-015021-pol2qm74	7858	17	following	follow	VBG
cord-015021-pol2qm74	7858	18	:	:	:
cord-015021-pol2qm74	7859	1	1	1	LS
cord-015021-pol2qm74	7859	2	)	)	-RRB-
cord-015021-pol2qm74	7859	3	IVIG	IVIG	NNP
cord-015021-pol2qm74	7859	4	plus	plus	CC
cord-015021-pol2qm74	7859	5	multimodal	multimodal	NN
cord-015021-pol2qm74	7859	6	treatment	treatment	NN
cord-015021-pol2qm74	7859	7	of	of	IN
cord-015021-pol2qm74	7859	8	sepsis	sepsis	NN
cord-015021-pol2qm74	7859	9	,	,	,
cord-015021-pol2qm74	7859	10	including	include	VBG
cord-015021-pol2qm74	7859	11	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	7859	12	,	,	,
cord-015021-pol2qm74	7859	13	reduce	reduce	VB
cord-015021-pol2qm74	7859	14	mortality	mortality	NN
cord-015021-pol2qm74	7859	15	significantly	significantly	RB
cord-015021-pol2qm74	7859	16	'	'	''
cord-015021-pol2qm74	7859	17	,	,	,
cord-015021-pol2qm74	7859	18	2	2	CD
cord-015021-pol2qm74	7859	19	)	)	-RRB-
cord-015021-pol2qm74	7859	20	the	the	DT
cord-015021-pol2qm74	7859	21	reduction	reduction	NN
cord-015021-pol2qm74	7859	22	of	of	IN
cord-015021-pol2qm74	7859	23	mortality	mortality	NN
cord-015021-pol2qm74	7859	24	seems	seem	VBZ
cord-015021-pol2qm74	7859	25	to	to	TO
cord-015021-pol2qm74	7859	26	be	be	VB
cord-015021-pol2qm74	7859	27	due	due	JJ
cord-015021-pol2qm74	7859	28	to	to	IN
cord-015021-pol2qm74	7859	29	a	a	DT
cord-015021-pol2qm74	7859	30	decreased	decrease	VBN
cord-015021-pol2qm74	7859	31	incidence	incidence	NN
cord-015021-pol2qm74	7859	32	of	of	IN
cord-015021-pol2qm74	7859	33	lethal	lethal	JJ
cord-015021-pol2qm74	7859	34	septic	septic	JJ
cord-015021-pol2qm74	7859	35	shock	shock	NN
cord-015021-pol2qm74	7859	36	.	.	.
cord-015021-pol2qm74	7860	1	Despite	despite	IN
cord-015021-pol2qm74	7860	2	substantial	substantial	JJ
cord-015021-pol2qm74	7860	3	clinical	clinical	JJ
cord-015021-pol2qm74	7860	4	research	research	NN
cord-015021-pol2qm74	7860	5	,	,	,
cord-015021-pol2qm74	7860	6	the	the	DT
cord-015021-pol2qm74	7860	7	avallable	avallable	JJ
cord-015021-pol2qm74	7860	8	data	datum	NNS
cord-015021-pol2qm74	7860	9	regarding	regard	VBG
cord-015021-pol2qm74	7860	10	the	the	DT
cord-015021-pol2qm74	7860	11	effectiveness	effectiveness	NN
cord-015021-pol2qm74	7860	12	of	of	IN
cord-015021-pol2qm74	7860	13	supplemental	supplemental	JJ
cord-015021-pol2qm74	7860	14	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	7860	15	(	(	-LRB-
cord-015021-pol2qm74	7860	16	Ig	Ig	NNP
cord-015021-pol2qm74	7860	17	)	)	-RRB-
cord-015021-pol2qm74	7860	18	treatment	treatment	NN
cord-015021-pol2qm74	7860	19	in	in	IN
cord-015021-pol2qm74	7860	20	sepsis	sepsis	NN
cord-015021-pol2qm74	7860	21	in	in	IN
cord-015021-pol2qm74	7860	22	adult	adult	NN
cord-015021-pol2qm74	7860	23	patients	patient	NNS
cord-015021-pol2qm74	7860	24	do	do	VBP
cord-015021-pol2qm74	7860	25	not	not	RB
cord-015021-pol2qm74	7860	26	yet	yet	RB
cord-015021-pol2qm74	7860	27	allow	allow	VB
cord-015021-pol2qm74	7860	28	definitive	definitive	JJ
cord-015021-pol2qm74	7860	29	conclusions	conclusion	NNS
cord-015021-pol2qm74	7860	30	.	.	.
cord-015021-pol2qm74	7861	1	In	in	IN
cord-015021-pol2qm74	7861	2	view	view	NN
cord-015021-pol2qm74	7861	3	of	of	IN
cord-015021-pol2qm74	7861	4	the	the	DT
cord-015021-pol2qm74	7861	5	persistently	persistently	RB
cord-015021-pol2qm74	7861	6	high	high	JJ
cord-015021-pol2qm74	7861	7	sepsis	sepsis	NN
cord-015021-pol2qm74	7861	8	mortality	mortality	NN
cord-015021-pol2qm74	7861	9	there	there	EX
cord-015021-pol2qm74	7861	10	is	be	VBZ
cord-015021-pol2qm74	7861	11	a	a	DT
cord-015021-pol2qm74	7861	12	need	need	NN
cord-015021-pol2qm74	7861	13	to	to	TO
cord-015021-pol2qm74	7861	14	continue	continue	VB
cord-015021-pol2qm74	7861	15	clinical	clinical	JJ
cord-015021-pol2qm74	7861	16	investxqations	investxqation	NNS
cord-015021-pol2qm74	7861	17	regarding	regard	VBG
cord-015021-pol2qm74	7861	18	supplemental	supplemental	JJ
cord-015021-pol2qm74	7861	19	sepsis	sepsis	NN
cord-015021-pol2qm74	7861	20	treatmen~	treatmen~	NN
cord-015021-pol2qm74	7861	21	in	in	IN
cord-015021-pol2qm74	7861	22	general	general	JJ
cord-015021-pol2qm74	7861	23	,	,	,
cord-015021-pol2qm74	7861	24	as	as	RB
cord-015021-pol2qm74	7861	25	well	well	RB
cord-015021-pol2qm74	7861	26	as	as	IN
cord-015021-pol2qm74	7861	27	concerning	concern	VBG
cord-015021-pol2qm74	7861	28	Ig	Ig	NNP
cord-015021-pol2qm74	7861	29	administration	administration	NN
cord-015021-pol2qm74	7861	30	in	in	IN
cord-015021-pol2qm74	7861	31	particular	particular	JJ
cord-015021-pol2qm74	7861	32	.	.	.
cord-015021-pol2qm74	7862	1	We	-PRON-	PRP
cord-015021-pol2qm74	7862	2	present	present	VBP
cord-015021-pol2qm74	7862	3	and	and	CC
cord-015021-pol2qm74	7862	4	discuss	discuss	VB
cord-015021-pol2qm74	7862	5	the	the	DT
cord-015021-pol2qm74	7862	6	protocol	protocol	NN
cord-015021-pol2qm74	7862	7	of	of	IN
cord-015021-pol2qm74	7862	8	the	the	DT
cord-015021-pol2qm74	7862	9	ongoing	ongoing	JJ
cord-015021-pol2qm74	7862	10	,	,	,
cord-015021-pol2qm74	7862	11	,	,	,
cord-015021-pol2qm74	7862	12	Score	score	NN
cord-015021-pol2qm74	7862	13	-	-	HYPH
cord-015021-pol2qm74	7862	14	Based	Based	NNP
cord-015021-pol2qm74	7862	15	-	-	HYPH
cord-015021-pol2qm74	7862	16	Immuneglobulin	Immuneglobulin	NNP
cord-015021-pol2qm74	7862	17	Therapy	Therapy	NNP
cord-015021-pol2qm74	7862	18	of	of	IN
cord-015021-pol2qm74	7862	19	Sepsis	Sepsis	NNP
cord-015021-pol2qm74	7862	20	(	(	-LRB-
cord-015021-pol2qm74	7862	21	SBITS	SBITS	NNP
cord-015021-pol2qm74	7862	22	)	)	-RRB-
cord-015021-pol2qm74	7862	23	"	"	``
cord-015021-pol2qm74	7862	24	study	study	NN
cord-015021-pol2qm74	7862	25	.	.	.
cord-015021-pol2qm74	7863	1	The	the	DT
cord-015021-pol2qm74	7863	2	protocol	protocol	NN
cord-015021-pol2qm74	7863	3	(	(	-LRB-
cord-015021-pol2qm74	7863	4	Theoret	Theoret	NNP
cord-015021-pol2qm74	7863	5	Surg	Surg	NNP
cord-015021-pol2qm74	7863	6	8(1993)61	8(1993)61	NN
cord-015021-pol2qm74	7863	7	-	-	HYPH
cord-015021-pol2qm74	7863	8	83	83	CD
cord-015021-pol2qm74	7863	9	)	)	-RRB-
cord-015021-pol2qm74	7863	10	of	of	IN
cord-015021-pol2qm74	7863	11	this	this	DT
cord-015021-pol2qm74	7863	12	multicenter	multicenter	NN
cord-015021-pol2qm74	7863	13	,	,	,
cord-015021-pol2qm74	7863	14	randomized	randomized	JJ
cord-015021-pol2qm74	7863	15	,	,	,
cord-015021-pol2qm74	7863	16	prospective	prospective	JJ
cord-015021-pol2qm74	7863	17	and	and	CC
cord-015021-pol2qm74	7863	18	double	double	JJ
cord-015021-pol2qm74	7863	19	-	-	HYPH
cord-015021-pol2qm74	7863	20	blind	blind	JJ
cord-015021-pol2qm74	7863	21	trfal	trfal	NN
cord-015021-pol2qm74	7863	22	relies	rely	VBZ
cord-015021-pol2qm74	7863	23	on	on	IN
cord-015021-pol2qm74	7863	24	the	the	DT
cord-015021-pol2qm74	7863	25	results	result	NNS
cord-015021-pol2qm74	7863	26	of	of	IN
cord-015021-pol2qm74	7863	27	an	an	DT
cord-015021-pol2qm74	7863	28	observational	observational	JJ
cord-015021-pol2qm74	7863	29	trial	trial	NN
cord-015021-pol2qm74	7863	30	on	on	IN
cord-015021-pol2qm74	7863	31	i.v	i.v	NNP
cord-015021-pol2qm74	7863	32	.	.	NNP
cord-015021-pol2qm74	7863	33	IgG	IgG	NNP
cord-015021-pol2qm74	7863	34	treatment	treatment	NN
cord-015021-pol2qm74	7863	35	in	in	IN
cord-015021-pol2qm74	7863	36	163	163	CD
cord-015021-pol2qm74	7863	37	patients	patient	NNS
cord-015021-pol2qm74	7863	38	with	with	IN
cord-015021-pol2qm74	7863	39	sepsis	sepsis	NN
cord-015021-pol2qm74	7863	40	and	and	CC
cord-015021-pol2qm74	7863	41	septic	septic	JJ
cord-015021-pol2qm74	7863	42	shock	shock	NN
cord-015021-pol2qm74	7863	43	(	(	-LRB-
cord-015021-pol2qm74	7863	44	Infection	infection	NN
cord-015021-pol2qm74	7863	45	19~1991)216	19~1991)216	NN
cord-015021-pol2qm74	7863	46	-	-	HYPH
cord-015021-pol2qm74	7863	47	227	227	CD
cord-015021-pol2qm74	7863	48	)	)	-RRB-
cord-015021-pol2qm74	7863	49	,	,	,
cord-015021-pol2qm74	7863	50	carried	carry	VBD
cord-015021-pol2qm74	7863	51	out	out	RP
cord-015021-pol2qm74	7863	52	as	as	IN
cord-015021-pol2qm74	7863	53	a	a	DT
cord-015021-pol2qm74	7863	54	prerequisite	prerequisite	NN
cord-015021-pol2qm74	7863	55	for	for	IN
cord-015021-pol2qm74	7863	56	the	the	DT
cord-015021-pol2qm74	7863	57	present	present	JJ
cord-015021-pol2qm74	7863	58	trial	trial	NN
cord-015021-pol2qm74	7863	59	.	.	.
cord-015021-pol2qm74	7864	1	Using	use	VBG
cord-015021-pol2qm74	7864	2	microcomputer	microcomputer	NN
cord-015021-pol2qm74	7864	3	-	-	HYPH
cord-015021-pol2qm74	7864	4	based	base	VBN
cord-015021-pol2qm74	7864	5	bedside	bedside	NN
cord-015021-pol2qm74	7864	6	routine	routine	JJ
cord-015021-pol2qm74	7864	7	score	score	NN
cord-015021-pol2qm74	7864	8	monitoring	monitoring	NN
cord-015021-pol2qm74	7864	9	,	,	,
cord-015021-pol2qm74	7864	10	we	-PRON-	PRP
cord-015021-pol2qm74	7864	11	regard	regard	VBP
cord-015021-pol2qm74	7864	12	quantitative	quantitative	JJ
cord-015021-pol2qm74	7864	13	measures	measure	NNS
cord-015021-pol2qm74	7864	14	of	of	IN
cord-015021-pol2qm74	7864	15	severity	severity	NN
cord-015021-pol2qm74	7864	16	of	of	IN
cord-015021-pol2qm74	7864	17	disease	disease	NN
cord-015021-pol2qm74	7864	18	and	and	CC
cord-015021-pol2qm74	7864	19	sepsis	sepsis	NN
cord-015021-pol2qm74	7864	20	:	:	:
cord-015021-pol2qm74	7864	21	only	only	RB
cord-015021-pol2qm74	7864	22	patients	patient	NNS
cord-015021-pol2qm74	7864	23	with	with	IN
cord-015021-pol2qm74	7864	24	a	a	DT
cord-015021-pol2qm74	7864	25	certain	certain	JJ
cord-015021-pol2qm74	7864	26	degree	degree	NN
cord-015021-pol2qm74	7864	27	of	of	IN
cord-015021-pol2qm74	7864	28	both	both	DT
cord-015021-pol2qm74	7864	29	severity	severity	NN
cord-015021-pol2qm74	7864	30	of	of	IN
cord-015021-pol2qm74	7864	31	disease	disease	NN
cord-015021-pol2qm74	7864	32	(	(	-LRB-
cord-015021-pol2qm74	7864	33	APACHE	APACHE	NNP
cord-015021-pol2qm74	7864	34	II	II	NNP
cord-015021-pol2qm74	7864	35	score	score	NN
cord-015021-pol2qm74	7864	36	20	20	CD
cord-015021-pol2qm74	7864	37	-	-	SYM
cord-015021-pol2qm74	7864	38	35	35	CD
cord-015021-pol2qm74	7864	39	)	)	-RRB-
cord-015021-pol2qm74	7864	40	and	and	CC
cord-015021-pol2qm74	7864	41	severity	severity	NN
cord-015021-pol2qm74	7864	42	of	of	IN
cord-015021-pol2qm74	7864	43	sepsis	sepsis	NN
cord-015021-pol2qm74	7864	44	(	(	-LRB-
cord-015021-pol2qm74	7864	45	Elebute	Elebute	NNP
cord-015021-pol2qm74	7864	46	sepsis	sepsis	NN
cord-015021-pol2qm74	7864	47	score	score	NN
cord-015021-pol2qm74	7864	48	12	12	CD
cord-015021-pol2qm74	7864	49	-	-	SYM
cord-015021-pol2qm74	7864	50	27	27	CD
cord-015021-pol2qm74	7864	51	)	)	-RRB-
cord-015021-pol2qm74	7864	52	will	will	MD
cord-015021-pol2qm74	7864	53	be	be	VB
cord-015021-pol2qm74	7864	54	included	include	VBN
cord-015021-pol2qm74	7864	55	.	.	.
cord-015021-pol2qm74	7865	1	By	by	IN
cord-015021-pol2qm74	7865	2	observing	observe	VBG
cord-015021-pol2qm74	7865	3	these	these	DT
cord-015021-pol2qm74	7865	4	previously	previously	RB
cord-015021-pol2qm74	7865	5	validated	validate	VBN
cord-015021-pol2qm74	7865	6	inclusion	inclusion	NN
cord-015021-pol2qm74	7865	7	criteria	criterion	NNS
cord-015021-pol2qm74	7865	8	,	,	,
cord-015021-pol2qm74	7865	9	this	this	DT
cord-015021-pol2qm74	7865	10	trial	trial	NN
cord-015021-pol2qm74	7865	11	snould	snould	MD
cord-015021-pol2qm74	7865	12	iQentify	iQentify	NNP
cord-015021-pol2qm74	7865	13	a	a	FW
cord-015021-pol2qm74	7865	14	priori	priori	FW
cord-015021-pol2qm74	7865	15	and	and	CC
cord-015021-pol2qm74	7865	16	include	include	VBP
cord-015021-pol2qm74	7865	17	patients	patient	NNS
cord-015021-pol2qm74	7865	18	with	with	IN
cord-015021-pol2qm74	7865	19	potentially	potentially	RB
cord-015021-pol2qm74	7865	20	optimal	optimal	JJ
cord-015021-pol2qm74	7865	21	response	response	NN
cord-015021-pol2qm74	7865	22	to	to	IN
cord-015021-pol2qm74	7865	23	therapy	therapy	NN
cord-015021-pol2qm74	7865	24	,	,	,
cord-015021-pol2qm74	7865	25	consisting	consist	VBG
cord-015021-pol2qm74	7865	26	o~	o~	XX
cord-015021-pol2qm74	7865	27	either	either	CC
cord-015021-pol2qm74	7865	28	placebo	placebo	NN
cord-015021-pol2qm74	7865	29	(	(	-LRB-
cord-015021-pol2qm74	7865	30	0.i	0.i	CD
cord-015021-pol2qm74	7865	31	%	%	NN
cord-015021-pol2qm74	7865	32	albumin	albumin	NN
cord-015021-pol2qm74	7865	33	)	)	-RRB-
cord-015021-pol2qm74	7865	34	or	or	CC
cord-015021-pol2qm74	7865	35	Polyglobin	Polyglobin	NNP
cord-015021-pol2qm74	7865	36	N	N	NNP
cord-015021-pol2qm74	7865	37	"	"	''
cord-015021-pol2qm74	7865	38	-12	-12	:
cord-015021-pol2qm74	7865	39	ml	ml	NN
cord-015021-pol2qm74	7865	40	(	(	-LRB-
cord-015021-pol2qm74	7865	41	0.6g)/kg	0.6g)/kg	CD
cord-015021-pol2qm74	7865	42	on	on	IN
cord-015021-pol2qm74	7865	43	day	day	NN
cord-015021-pol2qm74	7865	44	0	0	CD
cord-015021-pol2qm74	7865	45	and	and	CC
cord-015021-pol2qm74	7865	46	6ml	6ml	NN
cord-015021-pol2qm74	7865	47	(	(	-LRB-
cord-015021-pol2qm74	7865	48	0.3	0.3	CD
cord-015021-pol2qm74	7865	49	g)/kg	g)/kg	NNS
cord-015021-pol2qm74	7865	50	on	on	IN
cord-015021-pol2qm74	7865	51	day	day	NN
cord-015021-pol2qm74	7865	52	i.	i.	NN
cord-015021-pol2qm74	7866	1	With	with	IN
cord-015021-pol2qm74	7866	2	an	an	DT
cord-015021-pol2qm74	7866	3	anticipatedpopulation	anticipatedpopulation	NN
cord-015021-pol2qm74	7866	4	size	size	NN
cord-015021-pol2qm74	7866	5	of	of	IN
cord-015021-pol2qm74	7866	6	800	800	CD
cord-015021-pol2qm74	7866	7	patients	patient	NNS
cord-015021-pol2qm74	7866	8	the	the	DT
cord-015021-pol2qm74	7866	9	study	study	NN
cord-015021-pol2qm74	7866	10	should	should	MD
cord-015021-pol2qm74	7866	11	comply	comply	VB
cord-015021-pol2qm74	7866	12	with	with	IN
cord-015021-pol2qm74	7866	13	the	the	DT
cord-015021-pol2qm74	7866	14	statlstical	statlstical	JJ
cord-015021-pol2qm74	7866	15	requirements	requirement	NNS
cord-015021-pol2qm74	7866	16	(	(	-LRB-
cord-015021-pol2qm74	7866	17	estimated	estimate	VBN
cord-015021-pol2qm74	7866	18	mortality	mortality	NN
cord-015021-pol2qm74	7866	19	:	:	:
cord-015021-pol2qm74	7866	20	30	30	CD
cord-015021-pol2qm74	7866	21	%	%	NN
cord-015021-pol2qm74	7866	22	,	,	,
cord-015021-pol2qm74	7866	23	with	with	IN
cord-015021-pol2qm74	7866	24	a	a	DT
cord-015021-pol2qm74	7866	25	33	33	CD
cord-015021-pol2qm74	7866	26	%	%	NN
cord-015021-pol2qm74	7866	27	reduction	reduction	NN
cord-015021-pol2qm74	7866	28	in	in	IN
cord-015021-pol2qm74	7866	29	28-day	28-day	CD
cord-015021-pol2qm74	7866	30	mortality	mortality	NN
cord-015021-pol2qm74	7866	31	in	in	IN
cord-015021-pol2qm74	7866	32	the	the	DT
cord-015021-pol2qm74	7866	33	treatment	treatment	NN
cord-015021-pol2qm74	7866	34	groupl	groupl	NNS
cord-015021-pol2qm74	7866	35	to	to	TO
cord-015021-pol2qm74	7866	36	prove	prove	VB
cord-015021-pol2qm74	7866	37	or	or	CC
cord-015021-pol2qm74	7866	38	disprove	disprove	VB
cord-015021-pol2qm74	7866	39	the	the	DT
cord-015021-pol2qm74	7866	40	question	question	NN
cord-015021-pol2qm74	7866	41	of	of	IN
cord-015021-pol2qm74	7866	42	IgG	IgG	NNP
cord-015021-pol2qm74	7866	43	effectiveness	effectiveness	NN
cord-015021-pol2qm74	7866	44	in	in	IN
cord-015021-pol2qm74	7866	45	sepsis	sepsis	NN
cord-015021-pol2qm74	7866	46	in	in	IN
cord-015021-pol2qm74	7866	47	terms	term	NNS
cord-015021-pol2qm74	7866	48	of	of	IN
cord-015021-pol2qm74	7866	49	improved	improved	JJ
cord-015021-pol2qm74	7866	50	prognosis	prognosis	NN
cord-015021-pol2qm74	7866	51	.	.	.
cord-015021-pol2qm74	7867	1	Up	up	IN
cord-015021-pol2qm74	7867	2	to	to	IN
cord-015021-pol2qm74	7867	3	November	November	NNP
cord-015021-pol2qm74	7867	4	1993	1993	CD
cord-015021-pol2qm74	7867	5	,	,	,
cord-015021-pol2qm74	7867	6	more	more	JJR
cord-015021-pol2qm74	7867	7	than	than	IN
cord-015021-pol2qm74	7867	8	460	460	CD
cord-015021-pol2qm74	7867	9	patients	patient	NNS
cord-015021-pol2qm74	7867	10	had	have	VBD
cord-015021-pol2qm74	7867	11	been	be	VBN
cord-015021-pol2qm74	7867	12	included	include	VBN
cord-015021-pol2qm74	7867	13	;	;	:
cord-015021-pol2qm74	7867	14	patient	patient	JJ
cord-015021-pol2qm74	7867	15	enrollment	enrollment	NN
cord-015021-pol2qm74	7867	16	will	will	MD
cord-015021-pol2qm74	7867	17	be	be	VB
cord-015021-pol2qm74	7867	18	finished	finish	VBN
cord-015021-pol2qm74	7867	19	in	in	IN
cord-015021-pol2qm74	7867	20	1994	1994	CD
cord-015021-pol2qm74	7867	21	.	.	.
cord-015021-pol2qm74	7868	1	Previous	previous	JJ
cord-015021-pol2qm74	7868	2	studies	study	NNS
cord-015021-pol2qm74	7868	3	have	have	VBP
cord-015021-pol2qm74	7868	4	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7868	5	rhlL	rhll	JJ
cord-015021-pol2qm74	7868	6	-	-	:
cord-015021-pol2qm74	7868	7	I	I	NNP
cord-015021-pol2qm74	7868	8	ra	ra	NNP
cord-015021-pol2qm74	7868	9	,	,	,
cord-015021-pol2qm74	7868	10	a	a	DT
cord-015021-pol2qm74	7868	11	naturally	naturally	RB
cord-015021-pol2qm74	7868	12	occurring	occur	VBG
cord-015021-pol2qm74	7868	13	antagonist	antagonist	NN
cord-015021-pol2qm74	7868	14	of	of	IN
cord-015021-pol2qm74	7868	15	IL-1	IL-1	NNP
cord-015021-pol2qm74	7868	16	,	,	,
cord-015021-pol2qm74	7868	17	increases	increase	VBZ
cord-015021-pol2qm74	7868	18	survival	survival	NN
cord-015021-pol2qm74	7868	19	in	in	IN
cord-015021-pol2qm74	7868	20	animal	animal	NN
cord-015021-pol2qm74	7868	21	models	model	NNS
cord-015021-pol2qm74	7868	22	of	of	IN
cord-015021-pol2qm74	7868	23	andotoxemia	andotoxemia	NN
cord-015021-pol2qm74	7868	24	and	and	CC
cord-015021-pol2qm74	7868	25	EscheHchia	EscheHchia	NNP
cord-015021-pol2qm74	7868	26	coli	coli	VBZ
cord-015021-pol2qm74	7868	27	bacteremia	bacteremia	NN
cord-015021-pol2qm74	7868	28	and	and	CC
cord-015021-pol2qm74	7868	29	attenuates	attenuate	VBZ
cord-015021-pol2qm74	7868	30	the	the	DT
cord-015021-pol2qm74	7868	31	decrease	decrease	NN
cord-015021-pol2qm74	7868	32	in	in	IN
cord-015021-pol2qm74	7868	33	mean	mean	JJ
cord-015021-pol2qm74	7868	34	arterial	arterial	JJ
cord-015021-pol2qm74	7868	35	pressure	pressure	NN
cord-015021-pol2qm74	7868	36	resulting	result	VBG
cord-015021-pol2qm74	7868	37	from	from	IN
cord-015021-pol2qm74	7868	38	challenge	challenge	NN
cord-015021-pol2qm74	7868	39	with	with	IN
cord-015021-pol2qm74	7868	40	both	both	CC
cord-015021-pol2qm74	7868	41	gram	gram	NN
cord-015021-pol2qm74	7868	42	-	-	HYPH
cord-015021-pol2qm74	7868	43	negative	negative	JJ
cord-015021-pol2qm74	7868	44	and	and	CC
cord-015021-pol2qm74	7868	45	gram	gram	NN
cord-015021-pol2qm74	7868	46	-	-	HYPH
cord-015021-pol2qm74	7868	47	positive	positive	JJ
cord-015021-pol2qm74	7868	48	bacteria	bacteria	NNS
cord-015021-pol2qm74	7868	49	.	.	.
cord-015021-pol2qm74	7869	1	Previously	previously	RB
cord-015021-pol2qm74	7869	2	,	,	,
cord-015021-pol2qm74	7869	3	in	in	IN
cord-015021-pol2qm74	7869	4	99	99	CD
cord-015021-pol2qm74	7869	5	patients	patient	NNS
cord-015021-pol2qm74	7869	6	,	,	,
cord-015021-pol2qm74	7869	7	rhlL	rhlL	''
cord-015021-pol2qm74	7869	8	-	-	HYPH
cord-015021-pol2qm74	7869	9	lra	lra	NNP
cord-015021-pol2qm74	7869	10	was	be	VBD
cord-015021-pol2qm74	7869	11	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7869	12	to	to	TO
cord-015021-pol2qm74	7869	13	increase	increase	VB
cord-015021-pol2qm74	7869	14	survival	survival	NN
cord-015021-pol2qm74	7869	15	in	in	IN
cord-015021-pol2qm74	7869	16	patients	patient	NNS
cord-015021-pol2qm74	7869	17	with	with	IN
cord-015021-pol2qm74	7869	18	sepsis	sepsis	NN
cord-015021-pol2qm74	7869	19	syndrome	syndrome	NN
cord-015021-pol2qm74	7869	20	and	and	CC
cord-015021-pol2qm74	7869	21	septic	septic	JJ
cord-015021-pol2qm74	7869	22	shock	shock	NN
cord-015021-pol2qm74	7869	23	in	in	IN
cord-015021-pol2qm74	7869	24	a	a	DT
cord-015021-pol2qm74	7869	25	dose	dose	NN
cord-015021-pol2qm74	7869	26	-	-	HYPH
cord-015021-pol2qm74	7869	27	dependent	dependent	JJ
cord-015021-pol2qm74	7869	28	manner	manner	NN
cord-015021-pol2qm74	7869	29	.	.	.
cord-015021-pol2qm74	7870	1	Methods	method	NNS
cord-015021-pol2qm74	7870	2	:	:	:
cord-015021-pol2qm74	7870	3	A	a	DT
cord-015021-pol2qm74	7870	4	randomized	randomized	JJ
cord-015021-pol2qm74	7870	5	,	,	,
cord-015021-pol2qm74	7870	6	double	double	JJ
cord-015021-pol2qm74	7870	7	-	-	HYPH
cord-015021-pol2qm74	7870	8	blind	blind	JJ
cord-015021-pol2qm74	7870	9	,	,	,
cord-015021-pol2qm74	7870	10	placebo	placebo	NN
cord-015021-pol2qm74	7870	11	-	-	HYPH
cord-015021-pol2qm74	7870	12	controlled	control	VBN
cord-015021-pol2qm74	7870	13	,	,	,
cord-015021-pol2qm74	7870	14	malticenter	malticenter	NNP
cord-015021-pol2qm74	7870	15	,	,	,
cord-015021-pol2qm74	7870	16	clinical	clinical	JJ
cord-015021-pol2qm74	7870	17	trial	trial	NN
cord-015021-pol2qm74	7870	18	enrolled	enrol	VBD
cord-015021-pol2qm74	7870	19	893	893	CD
cord-015021-pol2qm74	7870	20	patients	patient	NNS
cord-015021-pol2qm74	7870	21	at	at	IN
cord-015021-pol2qm74	7870	22	63	63	CD
cord-015021-pol2qm74	7870	23	academic	academic	JJ
cord-015021-pol2qm74	7870	24	medical	medical	JJ
cord-015021-pol2qm74	7870	25	centers	center	NNS
cord-015021-pol2qm74	7870	26	in	in	IN
cord-015021-pol2qm74	7870	27	Europe	Europe	NNP
cord-015021-pol2qm74	7870	28	aad	aad	NNP
cord-015021-pol2qm74	7870	29	North	North	NNP
cord-015021-pol2qm74	7870	30	America	America	NNP
cord-015021-pol2qm74	7870	31	.	.	.
cord-015021-pol2qm74	7871	1	Eligible	eligible	JJ
cord-015021-pol2qm74	7871	2	patients	patient	NNS
cord-015021-pol2qm74	7871	3	received	receive	VBD
cord-015021-pol2qm74	7871	4	either	either	CC
cord-015021-pol2qm74	7871	5	placebo	placebo	NN
cord-015021-pol2qm74	7871	6	(	(	-LRB-
cord-015021-pol2qm74	7871	7	vehicle	vehicle	NN
cord-015021-pol2qm74	7871	8	)	)	-RRB-
cord-015021-pol2qm74	7871	9	or	or	CC
cord-015021-pol2qm74	7871	10	rhIL	rhIL	NNP
cord-015021-pol2qm74	7871	11	-	-	HYPH
cord-015021-pol2qm74	7871	12	lra	lra	NNP
cord-015021-pol2qm74	7871	13	(	(	-LRB-
cord-015021-pol2qm74	7871	14	anakinra	anakinra	NNP
cord-015021-pol2qm74	7871	15	)	)	-RRB-
cord-015021-pol2qm74	7871	16	1.0	1.0	CD
cord-015021-pol2qm74	7871	17	or	or	CC
cord-015021-pol2qm74	7871	18	2.0	2.0	CD
cord-015021-pol2qm74	7871	19	mg	mg	NNP
cord-015021-pol2qm74	7871	20	/	/	SYM
cord-015021-pol2qm74	7871	21	kg	kg	NNP
cord-015021-pol2qm74	7871	22	/	/	SYM
cord-015021-pol2qm74	7871	23	hr	hr	NN
cord-015021-pol2qm74	7871	24	by	by	IN
cord-015021-pol2qm74	7871	25	continuous	continuous	JJ
cord-015021-pol2qm74	7871	26	intravenous	intravenous	JJ
cord-015021-pol2qm74	7871	27	infusion	infusion	NN
cord-015021-pol2qm74	7871	28	for	for	IN
cord-015021-pol2qm74	7871	29	72	72	CD
cord-015021-pol2qm74	7871	30	hours	hour	NNS
cord-015021-pol2qm74	7871	31	.	.	.
cord-015021-pol2qm74	7872	1	The	the	DT
cord-015021-pol2qm74	7872	2	presence	presence	NN
cord-015021-pol2qm74	7872	3	of	of	IN
cord-015021-pol2qm74	7872	4	organ	organ	NN
cord-015021-pol2qm74	7872	5	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7872	6	(	(	-LRB-
cord-015021-pol2qm74	7872	7	i.e.	i.e.	FW
cord-015021-pol2qm74	7872	8	,	,	,
cord-015021-pol2qm74	7872	9	ARDS	ARDS	NNP
cord-015021-pol2qm74	7872	10	,	,	,
cord-015021-pol2qm74	7872	11	DIC	DIC	NNP
cord-015021-pol2qm74	7872	12	,	,	,
cord-015021-pol2qm74	7872	13	renal	renal	JJ
cord-015021-pol2qm74	7872	14	,	,	,
cord-015021-pol2qm74	7872	15	and	and	CC
cord-015021-pol2qm74	7872	16	hepatic	hepatic	JJ
cord-015021-pol2qm74	7872	17	)	)	-RRB-
cord-015021-pol2qm74	7872	18	at	at	IN
cord-015021-pol2qm74	7872	19	study	study	NN
cord-015021-pol2qm74	7872	20	entry	entry	NN
cord-015021-pol2qm74	7872	21	was	be	VBD
cord-015021-pol2qm74	7872	22	determined	determine	VBN
cord-015021-pol2qm74	7872	23	prospectively	prospectively	RB
cord-015021-pol2qm74	7872	24	by	by	IN
cord-015021-pol2qm74	7872	25	a	a	DT
cord-015021-pol2qm74	7872	26	Clinical	Clinical	NNP
cord-015021-pol2qm74	7872	27	Evaluation	Evaluation	NNP
cord-015021-pol2qm74	7872	28	Committee	Committee	NNP
cord-015021-pol2qm74	7872	29	using	use	VBG
cord-015021-pol2qm74	7872	30	definitions	definition	NNS
cord-015021-pol2qm74	7872	31	which	which	WDT
cord-015021-pol2qm74	7872	32	were	be	VBD
cord-015021-pol2qm74	7872	33	developed	develop	VBN
cord-015021-pol2qm74	7872	34	a	a	DT
cord-015021-pol2qm74	7872	35	-	-	HYPH
cord-015021-pol2qm74	7872	36	priori	priori	FW
cord-015021-pol2qm74	7872	37	.	.	.
cord-015021-pol2qm74	7873	1	Survival	survival	NN
cord-015021-pol2qm74	7873	2	time	time	NN
cord-015021-pol2qm74	7873	3	was	be	VBD
cord-015021-pol2qm74	7873	4	evaluated	evaluate	VBN
cord-015021-pol2qm74	7873	5	over	over	IN
cord-015021-pol2qm74	7873	6	28	28	CD
cord-015021-pol2qm74	7873	7	days	day	NNS
cord-015021-pol2qm74	7873	8	utilizing	utilize	VBG
cord-015021-pol2qm74	7873	9	a	a	DT
cord-015021-pol2qm74	7873	10	linear	linear	JJ
cord-015021-pol2qm74	7873	11	dose	dose	JJ
cord-015021-pol2qm74	7873	12	-	-	HYPH
cord-015021-pol2qm74	7873	13	response	response	NN
cord-015021-pol2qm74	7873	14	model	model	NN
cord-015021-pol2qm74	7873	15	,	,	,
cord-015021-pol2qm74	7873	16	assuming	assume	VBG
cord-015021-pol2qm74	7873	17	a	a	DT
cord-015021-pol2qm74	7873	18	log	log	NN
cord-015021-pol2qm74	7873	19	-	-	HYPH
cord-015021-pol2qm74	7873	20	normal	normal	JJ
cord-015021-pol2qm74	7873	21	distribution	distribution	NN
cord-015021-pol2qm74	7873	22	.	.	.
cord-015021-pol2qm74	7874	1	Results	result	NNS
cord-015021-pol2qm74	7874	2	:	:	:
cord-015021-pol2qm74	7875	1	563	563	CD
cord-015021-pol2qm74	7875	2	patients	patient	NNS
cord-015021-pol2qm74	7875	3	had	have	VBD
cord-015021-pol2qm74	7875	4	one	one	CD
cord-015021-pol2qm74	7875	5	or	or	CC
cord-015021-pol2qm74	7875	6	more	more	JJR
cord-015021-pol2qm74	7875	7	sepsis	sepsis	NN
cord-015021-pol2qm74	7875	8	-	-	HYPH
cord-015021-pol2qm74	7875	9	induced	induce	VBN
cord-015021-pol2qm74	7875	10	organ	organ	NN
cord-015021-pol2qm74	7875	11	dysfunction(s	dysfunction(s	NNP
cord-015021-pol2qm74	7875	12	)	)	-RRB-
cord-015021-pol2qm74	7875	13	at	at	IN
cord-015021-pol2qm74	7875	14	study	study	NN
cord-015021-pol2qm74	7875	15	entry	entry	NN
cord-015021-pol2qm74	7875	16	.	.	.
cord-015021-pol2qm74	7876	1	A	a	DT
cord-015021-pol2qm74	7876	2	dose	dose	NN
cord-015021-pol2qm74	7876	3	-	-	HYPH
cord-015021-pol2qm74	7876	4	related	relate	VBN
cord-015021-pol2qm74	7876	5	increase	increase	NN
cord-015021-pol2qm74	7876	6	in	in	IN
cord-015021-pol2qm74	7876	7	survival	survival	NN
cord-015021-pol2qm74	7876	8	time	time	NN
cord-015021-pol2qm74	7876	9	was	be	VBD
cord-015021-pol2qm74	7876	10	observed	observe	VBN
cord-015021-pol2qm74	7876	11	with	with	IN
cord-015021-pol2qm74	7876	12	rhlL	rhlL	NNP
cord-015021-pol2qm74	7876	13	-	-	HYPH
cord-015021-pol2qm74	7876	14	lra	lra	NNP
cord-015021-pol2qm74	7876	15	compared	compare	VBN
cord-015021-pol2qm74	7876	16	to	to	IN
cord-015021-pol2qm74	7876	17	placebo	placebo	NN
cord-015021-pol2qm74	7876	18	in	in	IN
cord-015021-pol2qm74	7876	19	patients	patient	NNS
cord-015021-pol2qm74	7876	20	with	with	IN
cord-015021-pol2qm74	7876	21	ARDS	ARDS	NNP
cord-015021-pol2qm74	7876	22	,	,	,
cord-015021-pol2qm74	7876	23	DIC	DIC	NNP
cord-015021-pol2qm74	7876	24	,	,	,
cord-015021-pol2qm74	7876	25	and	and	CC
cord-015021-pol2qm74	7876	26	renal	renal	JJ
cord-015021-pol2qm74	7876	27	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7876	28	(	(	-LRB-
cord-015021-pol2qm74	7876	29	P	p	NN
cord-015021-pol2qm74	7876	30	--	--	:
cord-015021-pol2qm74	7876	31	<	<	XX
cord-015021-pol2qm74	7876	32	0.04	0.04	CD
cord-015021-pol2qm74	7876	33	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	7876	34	infusion	infusion	NN
cord-015021-pol2qm74	7876	35	releases	release	VBZ
cord-015021-pol2qm74	7876	36	platelet	platelet	NN
cord-015021-pol2qm74	7876	37	-	-	HYPH
cord-015021-pol2qm74	7876	38	activating	activate	VBG
cord-015021-pol2qm74	7876	39	factor	factor	NN
cord-015021-pol2qm74	7876	40	(	(	-LRB-
cord-015021-pol2qm74	7876	41	PAF	PAF	NNP
cord-015021-pol2qm74	7876	42	)	)	-RRB-
cord-015021-pol2qm74	7876	43	,	,	,
cord-015021-pol2qm74	7876	44	a	a	DT
cord-015021-pol2qm74	7876	45	potent	potent	JJ
cord-015021-pol2qm74	7876	46	phospholipid	phospholipid	NN
cord-015021-pol2qm74	7876	47	mediator	mediator	NN
cord-015021-pol2qm74	7876	48	which	which	WDT
cord-015021-pol2qm74	7876	49	leads	lead	VBZ
cord-015021-pol2qm74	7876	50	to	to	IN
cord-015021-pol2qm74	7876	51	an	an	DT
cord-015021-pol2qm74	7876	52	autocatalytic	autocatalytic	JJ
cord-015021-pol2qm74	7876	53	amplification	amplification	NN
cord-015021-pol2qm74	7876	54	of	of	IN
cord-015021-pol2qm74	7876	55	cytokine	cytokine	NN
cord-015021-pol2qm74	7876	56	release	release	NN
cord-015021-pol2qm74	7876	57	.	.	.
cord-015021-pol2qm74	7877	1	BN	BN	NNP
cord-015021-pol2qm74	7877	2	52021	52021	CD
cord-015021-pol2qm74	7877	3	(	(	-LRB-
cord-015021-pol2qm74	7877	4	Ginkgolide	Ginkgolide	NNP
cord-015021-pol2qm74	7877	5	B	B	NNP
cord-015021-pol2qm74	7877	6	)	)	-RRB-
cord-015021-pol2qm74	7877	7	,	,	,
cord-015021-pol2qm74	7877	8	a	a	DT
cord-015021-pol2qm74	7877	9	natural	natural	JJ
cord-015021-pol2qm74	7877	10	PAF	PAF	NNP
cord-015021-pol2qm74	7877	11	receptor	receptor	NN
cord-015021-pol2qm74	7877	12	antagonist	antagonist	NN
cord-015021-pol2qm74	7877	13	,	,	,
cord-015021-pol2qm74	7877	14	has	have	VBZ
cord-015021-pol2qm74	7877	15	provided	provide	VBN
cord-015021-pol2qm74	7877	16	significant	significant	JJ
cord-015021-pol2qm74	7877	17	protection	protection	NN
cord-015021-pol2qm74	7877	18	against	against	IN
cord-015021-pol2qm74	7877	19	sepsis	sepsis	NN
cord-015021-pol2qm74	7877	20	in	in	IN
cord-015021-pol2qm74	7877	21	different	different	JJ
cord-015021-pol2qm74	7877	22	animal	animal	NN
cord-015021-pol2qm74	7877	23	models•	models•	.
cord-015021-pol2qm74	7878	1	A	a	DT
cord-015021-pol2qm74	7878	2	randomized	randomized	JJ
cord-015021-pol2qm74	7878	3	,	,	,
cord-015021-pol2qm74	7878	4	placebo	placebo	NN
cord-015021-pol2qm74	7878	5	-	-	HYPH
cord-015021-pol2qm74	7878	6	controlled	control	VBN
cord-015021-pol2qm74	7878	7	,	,	,
cord-015021-pol2qm74	7878	8	double	double	RB
cord-015021-pol2qm74	7878	9	blind	blind	JJ
cord-015021-pol2qm74	7878	10	,	,	,
cord-015021-pol2qm74	7878	11	multicenter	multicenter	JJ
cord-015021-pol2qm74	7878	12	trial	trial	NN
cord-015021-pol2qm74	7878	13	on	on	IN
cord-015021-pol2qm74	7878	14	efficacy	efficacy	NN
cord-015021-pol2qm74	7879	1	(	(	-LRB-
cord-015021-pol2qm74	7879	2	mortality	mortality	NN
cord-015021-pol2qm74	7879	3	at	at	IN
cord-015021-pol2qm74	7879	4	D28	D28	NNP
cord-015021-pol2qm74	7879	5	)	)	-RRB-
cord-015021-pol2qm74	7879	6	and	and	CC
cord-015021-pol2qm74	7879	7	tolerance	tolerance	NN
cord-015021-pol2qm74	7879	8	of	of	IN
cord-015021-pol2qm74	7879	9	BN	BN	NNP
cord-015021-pol2qm74	7879	10	52021	52021	CD
cord-015021-pol2qm74	7879	11	(	(	-LRB-
cord-015021-pol2qm74	7879	12	2	2	CD
cord-015021-pol2qm74	7879	13	IV	IV	NNP
cord-015021-pol2qm74	7879	14	infusion	infusion	NN
cord-015021-pol2qm74	7879	15	of	of	IN
cord-015021-pol2qm74	7879	16	120	120	CD
cord-015021-pol2qm74	7879	17	mg	mg	NN
cord-015021-pol2qm74	7879	18	x	x	SYM
cord-015021-pol2qm74	7879	19	2	2	CD
cord-015021-pol2qm74	7879	20	/	/	SYM
cord-015021-pol2qm74	7879	21	day	day	NN
cord-015021-pol2qm74	7879	22	over	over	IN
cord-015021-pol2qm74	7879	23	4	4	CD
cord-015021-pol2qm74	7879	24	days	day	NNS
cord-015021-pol2qm74	7879	25	)	)	-RRB-
cord-015021-pol2qm74	7879	26	in	in	IN
cord-015021-pol2qm74	7879	27	severe	severe	JJ
cord-015021-pol2qm74	7879	28	sepsis	sepsis	NN
cord-015021-pol2qm74	7879	29	has	have	VBZ
cord-015021-pol2qm74	7879	30	enrolled	enrol	VBN
cord-015021-pol2qm74	7879	31	262	262	CD
cord-015021-pol2qm74	7879	32	pts	pt	NNS
cord-015021-pol2qm74	7879	33	.	.	.
cord-015021-pol2qm74	7880	1	The	the	DT
cord-015021-pol2qm74	7880	2	28day	28day	NN
cord-015021-pol2qm74	7880	3	mortality	mortality	NN
cord-015021-pol2qm74	7880	4	rate	rate	NN
cord-015021-pol2qm74	7880	5	was	be	VBD
cord-015021-pol2qm74	7880	6	51	51	CD
cord-015021-pol2qm74	7880	7	%	%	NN
cord-015021-pol2qm74	7880	8	for	for	IN
cord-015021-pol2qm74	7880	9	the	the	DT
cord-015021-pol2qm74	7880	10	placebo	placebo	NN
cord-015021-pol2qm74	7880	11	group	group	NN
cord-015021-pol2qm74	7880	12	and	and	CC
cord-015021-pol2qm74	7880	13	42	42	CD
cord-015021-pol2qm74	7880	14	%	%	NN
cord-015021-pol2qm74	7880	15	for	for	IN
cord-015021-pol2qm74	7880	16	the	the	DT
cord-015021-pol2qm74	7880	17	BN	BN	NNP
cord-015021-pol2qm74	7880	18	52021	52021	CD
cord-015021-pol2qm74	7880	19	group	group	NN
cord-015021-pol2qm74	7880	20	(	(	-LRB-
cord-015021-pol2qm74	7880	21	P	p	NN
cord-015021-pol2qm74	7880	22	=	=	SYM
cord-015021-pol2qm74	7880	23	.17	.17	CD
cord-015021-pol2qm74	7880	24	)	)	-RRB-
cord-015021-pol2qm74	7880	25	.	.	.
cord-015021-pol2qm74	7881	1	The	the	DT
cord-015021-pol2qm74	7881	2	efficacy	efficacy	NN
cord-015021-pol2qm74	7881	3	of	of	IN
cord-015021-pol2qm74	7881	4	BN	BN	NNP
cord-015021-pol2qm74	7881	5	52021	52021	CD
cord-015021-pol2qm74	7881	6	was	be	VBD
cord-015021-pol2qm74	7881	7	greater	great	JJR
cord-015021-pol2qm74	7881	8	in	in	IN
cord-015021-pol2qm74	7881	9	pts	pts	NN
cord-015021-pol2qm74	7881	10	with	with	IN
cord-015021-pol2qm74	7881	11	gram	gram	JJ
cord-015021-pol2qm74	7881	12	-	-	HYPH
cord-015021-pol2qm74	7881	13	negative	negative	JJ
cord-015021-pol2qm74	7881	14	sepsis	sepsis	NN
cord-015021-pol2qm74	7881	15	:	:	:
cord-015021-pol2qm74	7881	16	the	the	DT
cord-015021-pol2qm74	7881	17	28-day	28-day	CD
cord-015021-pol2qm74	7881	18	mortality	mortality	NN
cord-015021-pol2qm74	7881	19	rate	rate	NN
cord-015021-pol2qm74	7881	20	was	be	VBD
cord-015021-pol2qm74	7881	21	57	57	CD
cord-015021-pol2qm74	7881	22	%	%	NN
cord-015021-pol2qm74	7881	23	for	for	IN
cord-015021-pol2qm74	7881	24	the	the	DT
cord-015021-pol2qm74	7881	25	placebo	placebo	NN
cord-015021-pol2qm74	7881	26	group	group	NN
cord-015021-pol2qm74	7881	27	and	and	CC
cord-015021-pol2qm74	7881	28	33	33	CD
cord-015021-pol2qm74	7881	29	%	%	NN
cord-015021-pol2qm74	7881	30	for	for	IN
cord-015021-pol2qm74	7881	31	the	the	DT
cord-015021-pol2qm74	7881	32	BN	BN	NNP
cord-015021-pol2qm74	7881	33	52021	52021	CD
cord-015021-pol2qm74	7881	34	group	group	NN
cord-015021-pol2qm74	7881	35	(	(	-LRB-
cord-015021-pol2qm74	7881	36	P	p	NN
cord-015021-pol2qm74	7881	37	=	=	SYM
cord-015021-pol2qm74	7881	38	.01	.01	NFP
cord-015021-pol2qm74	7881	39	)	)	-RRB-
cord-015021-pol2qm74	7881	40	.	.	.
cord-015021-pol2qm74	7882	1	BN	BN	NNP
cord-015021-pol2qm74	7882	2	52021	52021	CD
cord-015021-pol2qm74	7882	3	also	also	RB
cord-015021-pol2qm74	7882	4	reduced	reduce	VBD
cord-015021-pol2qm74	7882	5	mortality	mortality	NN
cord-015021-pol2qm74	7882	6	among	among	IN
cord-015021-pol2qm74	7882	7	pts	pt	NNS
cord-015021-pol2qm74	7882	8	with	with	IN
cord-015021-pol2qm74	7882	9	gram	gram	JJ
cord-015021-pol2qm74	7882	10	-	-	HYPH
cord-015021-pol2qm74	7882	11	negative	negative	JJ
cord-015021-pol2qm74	7882	12	septic	septic	JJ
cord-015021-pol2qm74	7882	13	shock	shock	NN
cord-015021-pol2qm74	7882	14	(	(	-LRB-
cord-015021-pol2qm74	7882	15	mortality	mortality	NN
cord-015021-pol2qm74	7882	16	was	be	VBD
cord-015021-pol2qm74	7882	17	65	65	CD
cord-015021-pol2qm74	7882	18	%	%	NN
cord-015021-pol2qm74	7882	19	for	for	IN
cord-015021-pol2qm74	7882	20	placebo	placebo	NN
cord-015021-pol2qm74	7882	21	vs	vs	IN
cord-015021-pol2qm74	7882	22	37	37	CD
cord-015021-pol2qm74	7882	23	%	%	NN
cord-015021-pol2qm74	7882	24	for	for	IN
cord-015021-pol2qm74	7882	25	BN	BN	NNP
cord-015021-pol2qm74	7882	26	52021	52021	CD
cord-015021-pol2qm74	7882	27	;	;	:
cord-015021-pol2qm74	7882	28	P	p	NN
cord-015021-pol2qm74	7882	29	=	=	SYM
cord-015021-pol2qm74	7882	30	.01	.01	NFP
cord-015021-pol2qm74	7882	31	)	)	-RRB-
cord-015021-pol2qm74	7882	32	.	.	.
cord-015021-pol2qm74	7883	1	Using	use	VBG
cord-015021-pol2qm74	7883	2	statistical	statistical	JJ
cord-015021-pol2qm74	7883	3	adjusments	adjusment	NNS
cord-015021-pol2qm74	7883	4	for	for	IN
cord-015021-pol2qm74	7883	5	pronostic	pronostic	JJ
cord-015021-pol2qm74	7883	6	factors	factor	NNS
cord-015021-pol2qm74	7883	7	,	,	,
cord-015021-pol2qm74	7883	8	the	the	DT
cord-015021-pol2qm74	7883	9	relative	relative	JJ
cord-015021-pol2qm74	7883	10	risk	risk	NN
cord-015021-pol2qm74	7883	11	of	of	IN
cord-015021-pol2qm74	7883	12	death	death	NN
cord-015021-pol2qm74	7883	13	of	of	IN
cord-015021-pol2qm74	7883	14	the	the	DT
cord-015021-pol2qm74	7883	15	BN	BN	NNP
cord-015021-pol2qm74	7883	16	52021	52021	CD
cord-015021-pol2qm74	7883	17	group	group	NN
cord-015021-pol2qm74	7883	18	was	be	VBD
cord-015021-pol2qm74	7883	19	0.61	0.61	CD
cord-015021-pol2qm74	7883	20	(	(	-LRB-
cord-015021-pol2qm74	7883	21	0.34	0.34	CD
cord-015021-pol2qm74	7883	22	-1.08	-1.08	CD
cord-015021-pol2qm74	7883	23	,	,	,
cord-015021-pol2qm74	7883	24	95	95	CD
cord-015021-pol2qm74	7883	25	%	%	NN
cord-015021-pol2qm74	7883	26	confidence	confidence	NN
cord-015021-pol2qm74	7883	27	interval	interval	NN
cord-015021-pol2qm74	7883	28	;	;	:
cord-015021-pol2qm74	7883	29	P	p	NN
cord-015021-pol2qm74	7883	30	=	=	SYM
cord-015021-pol2qm74	7883	31	.09	.09	CD
cord-015021-pol2qm74	7883	32	)	)	-RRB-
cord-015021-pol2qm74	7883	33	.	.	.
cord-015021-pol2qm74	7884	1	This	this	DT
cord-015021-pol2qm74	7884	2	risk	risk	NN
cord-015021-pol2qm74	7884	3	corresponds	correspond	VBZ
cord-015021-pol2qm74	7884	4	to	to	IN
cord-015021-pol2qm74	7884	5	an	an	DT
cord-015021-pol2qm74	7884	6	adjusted	adjust	VBN
cord-015021-pol2qm74	7884	7	reduction	reduction	NN
cord-015021-pol2qm74	7884	8	in	in	IN
cord-015021-pol2qm74	7884	9	mortality	mortality	NN
cord-015021-pol2qm74	7884	10	of	of	IN
cord-015021-pol2qm74	7884	11	39	39	CD
cord-015021-pol2qm74	7884	12	%	%	NN
cord-015021-pol2qm74	7884	13	for	for	IN
cord-015021-pol2qm74	7884	14	pts	pt	NNS
cord-015021-pol2qm74	7884	15	receiving	receive	VBG
cord-015021-pol2qm74	7884	16	BN	BN	NNP
cord-015021-pol2qm74	7884	17	52021	52021	CD
cord-015021-pol2qm74	7884	18	.	.	.
cord-015021-pol2qm74	7885	1	No	no	DT
cord-015021-pol2qm74	7885	2	differences	difference	NNS
cord-015021-pol2qm74	7885	3	in	in	IN
cord-015021-pol2qm74	7885	4	mortality	mortality	NN
cord-015021-pol2qm74	7885	5	rates	rate	NNS
cord-015021-pol2qm74	7885	6	were	be	VBD
cord-015021-pol2qm74	7885	7	found	find	VBN
cord-015021-pol2qm74	7885	8	between	between	IN
cord-015021-pol2qm74	7885	9	the	the	DT
cord-015021-pol2qm74	7885	10	placebo	placebo	NN
cord-015021-pol2qm74	7885	11	and	and	CC
cord-015021-pol2qm74	7885	12	the	the	DT
cord-015021-pol2qm74	7885	13	BN	BN	NNP
cord-015021-pol2qm74	7885	14	52021	52021	CD
cord-015021-pol2qm74	7885	15	groups	group	NNS
cord-015021-pol2qm74	7885	16	in	in	IN
cord-015021-pol2qm74	7885	17	the	the	DT
cord-015021-pol2qm74	7885	18	absence	absence	NN
cord-015021-pol2qm74	7885	19	of	of	IN
cord-015021-pol2qm74	7885	20	gram	gram	NN
cord-015021-pol2qm74	7885	21	-	-	HYPH
cord-015021-pol2qm74	7885	22	negative	negative	JJ
cord-015021-pol2qm74	7885	23	sepsis•	sepsis•	XX
cord-015021-pol2qm74	7886	1	There	there	EX
cord-015021-pol2qm74	7886	2	were	be	VBD
cord-015021-pol2qm74	7886	3	no	no	DT
cord-015021-pol2qm74	7886	4	differences	difference	NNS
cord-015021-pol2qm74	7886	5	in	in	IN
cord-015021-pol2qm74	7886	6	adverse	adverse	JJ
cord-015021-pol2qm74	7886	7	events	event	NNS
cord-015021-pol2qm74	7886	8	between	between	IN
cord-015021-pol2qm74	7886	9	the	the	DT
cord-015021-pol2qm74	7886	10	placebo	placebo	NN
cord-015021-pol2qm74	7886	11	and	and	CC
cord-015021-pol2qm74	7886	12	the	the	DT
cord-015021-pol2qm74	7886	13	BN	BN	NNP
cord-015021-pol2qm74	7886	14	52021	52021	CD
cord-015021-pol2qm74	7886	15	groups	group	NNS
cord-015021-pol2qm74	7886	16	.	.	.
cord-015021-pol2qm74	7887	1	BN	BN	NNP
cord-015021-pol2qm74	7887	2	52021	52021	CD
cord-015021-pol2qm74	7887	3	is	be	VBZ
cord-015021-pol2qm74	7887	4	a	a	DT
cord-015021-pol2qm74	7887	5	safe	safe	JJ
cord-015021-pol2qm74	7887	6	and	and	CC
cord-015021-pol2qm74	7887	7	promising	promising	JJ
cord-015021-pol2qm74	7887	8	treatment	treatment	NN
cord-015021-pol2qm74	7887	9	for	for	IN
cord-015021-pol2qm74	7887	10	patients	patient	NNS
cord-015021-pol2qm74	7887	11	with	with	IN
cord-015021-pol2qm74	7887	12	severe	severe	JJ
cord-015021-pol2qm74	7887	13	gram	gram	NN
cord-015021-pol2qm74	7887	14	-	-	HYPH
cord-015021-pol2qm74	7887	15	negative	negative	JJ
cord-015021-pol2qm74	7887	16	sepsis	sepsis	NN
cord-015021-pol2qm74	7887	17	.	.	.
cord-015021-pol2qm74	7888	1	A	a	DT
cord-015021-pol2qm74	7888	2	confirming	confirm	VBG
cord-015021-pol2qm74	7888	3	study	study	NN
cord-015021-pol2qm74	7888	4	,	,	,
cord-015021-pol2qm74	7888	5	focused	focus	VBD
cord-015021-pol2qm74	7888	6	on	on	IN
cord-015021-pol2qm74	7888	7	gram	gram	NN
cord-015021-pol2qm74	7888	8	negative	negative	JJ
cord-015021-pol2qm74	7888	9	sepsis	sepsis	NN
cord-015021-pol2qm74	7888	10	,	,	,
cord-015021-pol2qm74	7888	11	is	be	VBZ
cord-015021-pol2qm74	7888	12	In	in	IN
cord-015021-pol2qm74	7888	13	progress	progress	NN
cord-015021-pol2qm74	7888	14	.	.	.
cord-015021-pol2qm74	7889	1	V~3lliam	V~3lliam	NNP
cord-015021-pol2qm74	7889	2	A.	a.	NN
cord-015021-pol2qm74	7889	3	Kanus	Kanus	NNP
cord-015021-pol2qm74	7889	4	M.D.	M.D.	NNP
cord-015021-pol2qm74	7889	5	and	and	CC
cord-015021-pol2qm74	7889	6	The	the	DT
cord-015021-pol2qm74	7889	7	rhlL	rhlL	NNP
cord-015021-pol2qm74	7889	8	-	-	HYPH
cord-015021-pol2qm74	7889	9	lra	lra	NNP
cord-015021-pol2qm74	7890	1	It	-PRON-	PRP
cord-015021-pol2qm74	7890	2	has	have	VBZ
cord-015021-pol2qm74	7890	3	been	be	VBN
cord-015021-pol2qm74	7890	4	traditional	traditional	JJ
cord-015021-pol2qm74	7890	5	within	within	IN
cord-015021-pol2qm74	7890	6	the	the	DT
cord-015021-pol2qm74	7890	7	field	field	NN
cord-015021-pol2qm74	7890	8	of	of	IN
cord-015021-pol2qm74	7890	9	infection	infection	NN
cord-015021-pol2qm74	7890	10	and	and	CC
cord-015021-pol2qm74	7890	11	sepsis	sepsis	NN
cord-015021-pol2qm74	7890	12	to	to	TO
cord-015021-pol2qm74	7890	13	think	think	VB
cord-015021-pol2qm74	7890	14	in	in	IN
cord-015021-pol2qm74	7890	15	terms	term	NNS
cord-015021-pol2qm74	7890	16	of	of	IN
cord-015021-pol2qm74	7890	17	specific	specific	JJ
cord-015021-pol2qm74	7890	18	indications	indication	NNS
cord-015021-pol2qm74	7890	19	for	for	IN
cord-015021-pol2qm74	7890	20	drugs	drug	NNS
cord-015021-pol2qm74	7890	21	based	base	VBN
cord-015021-pol2qm74	7890	22	on	on	IN
cord-015021-pol2qm74	7890	23	the	the	DT
cord-015021-pol2qm74	7890	24	type	type	NN
cord-015021-pol2qm74	7890	25	of	of	IN
cord-015021-pol2qm74	7890	26	infecting	infect	VBG
cord-015021-pol2qm74	7890	27	organisms	organism	NNS
cord-015021-pol2qm74	7890	28	,	,	,
cord-015021-pol2qm74	7890	29	Advances	advance	NNS
cord-015021-pol2qm74	7890	30	in	in	IN
cord-015021-pol2qm74	7890	31	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	7890	32	therapy	therapy	NN
cord-015021-pol2qm74	7890	33	now	now	RB
cord-015021-pol2qm74	7890	34	control	control	VBP
cord-015021-pol2qm74	7890	35	or	or	CC
cord-015021-pol2qm74	7890	36	ltnflt	ltnflt	VBD
cord-015021-pol2qm74	7890	37	the	the	DT
cord-015021-pol2qm74	7890	38	growth	growth	NN
cord-015021-pol2qm74	7890	39	of	of	IN
cord-015021-pol2qm74	7890	40	bacteria	bacteria	NNS
cord-015021-pol2qm74	7890	41	.	.	.
cord-015021-pol2qm74	7891	1	The	the	DT
cord-015021-pol2qm74	7891	2	majority	majority	NN
cord-015021-pol2qm74	7891	3	of	of	IN
cord-015021-pol2qm74	7891	4	deaths	death	NNS
cord-015021-pol2qm74	7891	5	are	be	VBP
cord-015021-pol2qm74	7891	6	now	now	RB
cord-015021-pol2qm74	7891	7	caused	cause	VBN
cord-015021-pol2qm74	7891	8	by	by	IN
cord-015021-pol2qm74	7891	9	either	either	CC
cord-015021-pol2qm74	7891	10	an	an	DT
cord-015021-pol2qm74	7891	11	initial	initial	JJ
cord-015021-pol2qm74	7891	12	overwhelming	overwhelming	JJ
cord-015021-pol2qm74	7891	13	response	response	NN
cord-015021-pol2qm74	7891	14	to	to	IN
cord-015021-pol2qm74	7891	15	infection	infection	NN
cord-015021-pol2qm74	7891	16	or	or	CC
cord-015021-pol2qm74	7891	17	subsequent	subsequent	JJ
cord-015021-pol2qm74	7891	18	multiple	multiple	JJ
cord-015021-pol2qm74	7891	19	organ	organ	NN
cord-015021-pol2qm74	7891	20	system	system	NN
cord-015021-pol2qm74	7891	21	failure	failure	NN
cord-015021-pol2qm74	7891	22	attributed	attribute	VBN
cord-015021-pol2qm74	7891	23	,	,	,
cord-015021-pol2qm74	7891	24	in	in	IN
cord-015021-pol2qm74	7891	25	part	part	NN
cord-015021-pol2qm74	7891	26	,	,	,
cord-015021-pol2qm74	7891	27	to	to	IN
cord-015021-pol2qm74	7891	28	the	the	DT
cord-015021-pol2qm74	7891	29	effects	effect	NNS
cord-015021-pol2qm74	7891	30	of	of	IN
cord-015021-pol2qm74	7891	31	intrinsic	intrinsic	JJ
cord-015021-pol2qm74	7891	32	biologic	biologic	JJ
cord-015021-pol2qm74	7891	33	responses	response	NNS
cord-015021-pol2qm74	7891	34	of	of	IN
cord-015021-pol2qm74	7891	35	the	the	DT
cord-015021-pol2qm74	7891	36	host	host	NN
cord-015021-pol2qm74	7891	37	.	.	.
cord-015021-pol2qm74	7892	1	Type	type	NN
cord-015021-pol2qm74	7892	2	of	of	IN
cord-015021-pol2qm74	7892	3	organism	organism	NN
cord-015021-pol2qm74	7892	4	,	,	,
cord-015021-pol2qm74	7892	5	therefore	therefore	RB
cord-015021-pol2qm74	7892	6	,	,	,
cord-015021-pol2qm74	7892	7	may	may	MD
cord-015021-pol2qm74	7892	8	not	not	RB
cord-015021-pol2qm74	7892	9	be	be	VB
cord-015021-pol2qm74	7892	10	as	as	RB
cord-015021-pol2qm74	7892	11	critical	critical	JJ
cord-015021-pol2qm74	7892	12	as	as	IN
cord-015021-pol2qm74	7892	13	determining	determine	VBG
cord-015021-pol2qm74	7892	14	the	the	DT
cord-015021-pol2qm74	7892	15	exact	exact	JJ
cord-015021-pol2qm74	7892	16	severity	severity	NN
cord-015021-pol2qm74	7892	17	of	of	IN
cord-015021-pol2qm74	7892	18	the	the	DT
cord-015021-pol2qm74	7892	19	host	host	NN
cord-015021-pol2qm74	7892	20	's	's	POS
cord-015021-pol2qm74	7892	21	severity	severity	NN
cord-015021-pol2qm74	7892	22	or	or	CC
cord-015021-pol2qm74	7892	23	risk	risk	NN
cord-015021-pol2qm74	7892	24	of	of	IN
cord-015021-pol2qm74	7892	25	death	death	NN
cord-015021-pol2qm74	7892	26	from	from	IN
cord-015021-pol2qm74	7892	27	infection	infection	NN
cord-015021-pol2qm74	7892	28	.	.	.
cord-015021-pol2qm74	7893	1	We	-PRON-	PRP
cord-015021-pol2qm74	7893	2	also	also	RB
cord-015021-pol2qm74	7893	3	know	know	VBP
cord-015021-pol2qm74	7893	4	that	that	IN
cord-015021-pol2qm74	7893	5	both	both	CC
cord-015021-pol2qm74	7893	6	the	the	DT
cord-015021-pol2qm74	7893	7	relative	relative	JJ
cord-015021-pol2qm74	7893	8	benefit	benefit	NN
cord-015021-pol2qm74	7893	9	of	of	IN
cord-015021-pol2qm74	7893	10	a	a	DT
cord-015021-pol2qm74	7893	11	new	new	JJ
cord-015021-pol2qm74	7893	12	treatment	treatment	NN
cord-015021-pol2qm74	7893	13	across	across	IN
cord-015021-pol2qm74	7893	14	groups	group	NNS
cord-015021-pol2qm74	7893	15	and	and	CC
cord-015021-pol2qm74	7893	16	its	-PRON-	PRP$
cord-015021-pol2qm74	7893	17	absolute	absolute	JJ
cord-015021-pol2qm74	7893	18	benefit	benefit	NN
cord-015021-pol2qm74	7893	19	for	for	IN
cord-015021-pol2qm74	7893	20	an	an	DT
cord-015021-pol2qm74	7893	21	Individual	individual	JJ
cord-015021-pol2qm74	7893	22	patient	patient	NN
cord-015021-pol2qm74	7893	23	will	will	MD
cord-015021-pol2qm74	7893	24	vary	vary	VB
cord-015021-pol2qm74	7893	25	with	with	IN
cord-015021-pol2qm74	7893	26	their	-PRON-	PRP$
cord-015021-pol2qm74	7893	27	risk	risk	NN
cord-015021-pol2qm74	7893	28	in	in	IN
cord-015021-pol2qm74	7893	29	a	a	DT
cord-015021-pol2qm74	7893	30	predictable	predictable	JJ
cord-015021-pol2qm74	7893	31	fashion	fashion	NN
cord-015021-pol2qm74	7893	32	.	.	.
cord-015021-pol2qm74	7894	1	We	-PRON-	PRP
cord-015021-pol2qm74	7894	2	recently	recently	RB
cord-015021-pol2qm74	7894	3	iuve	iuve	VBD
cord-015021-pol2qm74	7894	4	~	~	NFP
cord-015021-pol2qm74	7894	5	iguted	igute	VBD
cord-015021-pol2qm74	7894	6	the	the	DT
cord-015021-pol2qm74	7894	7	relationship	relationship	NN
cord-015021-pol2qm74	7894	8	between	between	IN
cord-015021-pol2qm74	7894	9	one	one	CD
cord-015021-pol2qm74	7894	10	measure	measure	NN
cord-015021-pol2qm74	7894	11	of	of	IN
cord-015021-pol2qm74	7894	12	host	host	NN
cord-015021-pol2qm74	7894	13	response	response	NN
cord-015021-pol2qm74	7894	14	,	,	,
cord-015021-pol2qm74	7894	15	the	the	DT
cord-015021-pol2qm74	7894	16	acute	acute	JJ
cord-015021-pol2qm74	7894	17	risk	risk	NN
cord-015021-pol2qm74	7894	18	of	of	IN
cord-015021-pol2qm74	7894	19	death	death	NN
cord-015021-pol2qm74	7894	20	as	as	IN
cord-015021-pol2qm74	7894	21	prospectively	prospectively	RB
cord-015021-pol2qm74	7894	22	estimated	estimate	VBN
cord-015021-pol2qm74	7894	23	by	by	IN
cord-015021-pol2qm74	7894	24	u	u	NNP
cord-015021-pol2qm74	7894	25	comprehensive	comprehensive	JJ
cord-015021-pol2qm74	7894	26	risk	risk	NN
cord-015021-pol2qm74	7894	27	mode	mode	NN
cord-015021-pol2qm74	7894	28	[	[	-LRB-
cord-015021-pol2qm74	7894	29	for	for	IN
cord-015021-pol2qm74	7894	30	28-day	28-day	CD
cord-015021-pol2qm74	7894	31	mortality	mortality	NN
cord-015021-pol2qm74	7894	32	(	(	-LRB-
cord-015021-pol2qm74	7894	33	JAMb	JAMb	NNP
cord-015021-pol2qm74	7894	34	.	.	.
cord-015021-pol2qm74	7894	35	1993	1993	CD
cord-015021-pol2qm74	7894	36	;	;	:
cord-015021-pol2qm74	7894	37	270:12,33	270:12,33	CD
cord-015021-pol2qm74	7894	38	-	-	HYPH
cord-015021-pol2qm74	7894	39	1241	1241	CD
cord-015021-pol2qm74	7894	40	)	)	-RRB-
cord-015021-pol2qm74	7894	41	,	,	,
cord-015021-pol2qm74	7894	42	by	by	IN
cord-015021-pol2qm74	7894	43	its	-PRON-	PRP$
cord-015021-pol2qm74	7894	44	retrospective	retrospective	JJ
cord-015021-pol2qm74	7894	45	application	application	NN
cord-015021-pol2qm74	7894	46	to	to	IN
cord-015021-pol2qm74	7894	47	the	the	DT
cord-015021-pol2qm74	7894	48	results	result	NNS
cord-015021-pol2qm74	7894	49	from	from	IN
cord-015021-pol2qm74	7894	50	the	the	DT
cord-015021-pol2qm74	7894	51	Phase	phase	NN
cord-015021-pol2qm74	7895	1	In	in	IN
cord-015021-pol2qm74	7895	2	evaluation	evaluation	NN
cord-015021-pol2qm74	7895	3	of	of	IN
cord-015021-pol2qm74	7895	4	recombinant	recombinant	JJ
cord-015021-pol2qm74	7895	5	human	human	NN
cord-015021-pol2qm74	7895	6	intcrlenkin-1	intcrlenkin-1	NNP
cord-015021-pol2qm74	7895	7	receptor	receptor	NN
cord-015021-pol2qm74	7895	8	antagonist	antagonist	NN
cord-015021-pol2qm74	7895	9	(	(	-LRB-
cord-015021-pol2qm74	7895	10	rhlL.	rhlL.	NNP
cord-015021-pol2qm74	7895	11	Ira	Ira	NNP
cord-015021-pol2qm74	7895	12	)	)	-RRB-
cord-015021-pol2qm74	7895	13	.	.	.
cord-015021-pol2qm74	7896	1	We	-PRON-	PRP
cord-015021-pol2qm74	7896	2	found	find	VBD
cord-015021-pol2qm74	7896	3	that	that	IN
cord-015021-pol2qm74	7896	4	there	there	EX
cord-015021-pol2qm74	7896	5	was	be	VBD
cord-015021-pol2qm74	7896	6	a	a	DT
cord-015021-pol2qm74	7896	7	significant	significant	JJ
cord-015021-pol2qm74	7896	8	interaction	interaction	NN
cord-015021-pol2qm74	7896	9	between	between	IN
cord-015021-pol2qm74	7896	10	the	the	DT
cord-015021-pol2qm74	7896	11	patient	patient	NN
cord-015021-pol2qm74	7896	12	's	's	POS
cord-015021-pol2qm74	7896	13	predicted	predict	VBN
cord-015021-pol2qm74	7896	14	risk	risk	NN
cord-015021-pol2qm74	7896	15	of	of	IN
cord-015021-pol2qm74	7896	16	mortality	mortality	NN
cord-015021-pol2qm74	7896	17	at	at	IN
cord-015021-pol2qm74	7896	18	the	the	DT
cord-015021-pol2qm74	7896	19	time	time	NN
cord-015021-pol2qm74	7896	20	of	of	IN
cord-015021-pol2qm74	7896	21	entry	entry	NN
cord-015021-pol2qm74	7896	22	to	to	IN
cord-015021-pol2qm74	7896	23	the	the	DT
cord-015021-pol2qm74	7896	24	study	study	NN
cord-015021-pol2qm74	7896	25	and	and	CC
cord-015021-pol2qm74	7896	26	the	the	DT
cord-015021-pol2qm74	7896	27	ability	ability	NN
cord-015021-pol2qm74	7896	28	of	of	IN
cord-015021-pol2qm74	7896	29	rhIL	rhIL	NNP
cord-015021-pol2qm74	7896	30	-	-	HYPH
cord-015021-pol2qm74	7896	31	lra	lra	NNP
cord-015021-pol2qm74	7896	32	to	to	TO
cord-015021-pol2qm74	7896	33	prolong	prolong	VB
cord-015021-pol2qm74	7896	34	survival	survival	NN
cord-015021-pol2qm74	7896	35	time	time	NN
cord-015021-pol2qm74	7896	36	(	(	-LRB-
cord-015021-pol2qm74	7896	37	X2	x2	NN
cord-015021-pol2qm74	7896	38	=	=	SYM
cord-015021-pol2qm74	7896	39	7.6	7.6	CD
cord-015021-pol2qm74	7896	40	,	,	,
cord-015021-pol2qm74	7896	41	p	p	NN
cord-015021-pol2qm74	7896	42	[	[	-LRB-
cord-015021-pol2qm74	7896	43	]	]	-RRB-
cord-015021-pol2qm74	7896	44	0.02	0.02	CD
cord-015021-pol2qm74	7896	45	,	,	,
cord-015021-pol2qm74	7896	46	log.normal	log.normal	NNP
cord-015021-pol2qm74	7896	47	)	)	-RRB-
cord-015021-pol2qm74	7896	48	for	for	IN
cord-015021-pol2qm74	7896	49	all	all	DT
cord-015021-pol2qm74	7896	50	893	893	CD
cord-015021-pol2qm74	7896	51	patients	patient	NNS
cord-015021-pol2qm74	7896	52	in	in	IN
cord-015021-pol2qm74	7896	53	the	the	DT
cord-015021-pol2qm74	7896	54	trial•	trial•	NNP
cord-015021-pol2qm74	7896	55	Survival	Survival	NNP
cord-015021-pol2qm74	7896	56	benefit	benefit	NN
cord-015021-pol2qm74	7896	57	began	begin	VBD
cord-015021-pol2qm74	7896	58	st	st	NNP
cord-015021-pol2qm74	7896	59	approximately	approximately	RB
cord-015021-pol2qm74	7896	60	24	24	CD
cord-015021-pol2qm74	7896	61	%	%	NN
cord-015021-pol2qm74	7896	62	baseline	baseline	JJ
cord-015021-pol2qm74	7896	63	risk	risk	NN
cord-015021-pol2qm74	7896	64	of	of	IN
cord-015021-pol2qm74	7896	65	28-day	28-day	CD
cord-015021-pol2qm74	7896	66	mortality	mortality	NN
cord-015021-pol2qm74	7896	67	.	.	.
cord-015021-pol2qm74	7897	1	For	for	IN
cord-015021-pol2qm74	7897	2	the	the	DT
cord-015021-pol2qm74	7897	3	$	$	$
cord-015021-pol2qm74	7897	4	80	80	CD
cord-015021-pol2qm74	7897	5	patients	patient	NNS
cord-015021-pol2qm74	7897	6	with	with	IN
cord-015021-pol2qm74	7897	7	a	a	DT
cord-015021-pol2qm74	7897	8	predicted	predict	VBN
cord-015021-pol2qm74	7897	9	risk	risk	NN
cord-015021-pol2qm74	7897	10	>	>	XX
cord-015021-pol2qm74	7897	11	24	24	CD
cord-015021-pol2qm74	7897	12	%	%	NN
cord-015021-pol2qm74	7897	13	,	,	,
cord-015021-pol2qm74	7897	14	there	there	EX
cord-015021-pol2qm74	7897	15	was	be	VBD
cord-015021-pol2qm74	7897	16	a	a	DT
cord-015021-pol2qm74	7897	17	22	22	CD
cord-015021-pol2qm74	7897	18	%	%	NN
cord-015021-pol2qm74	7897	19	reduction	reduction	NN
cord-015021-pol2qm74	7897	20	(	(	-LRB-
cord-015021-pol2qm74	7897	21	P=0,00	P=0,00	NNP
cord-015021-pol2qm74	7897	22	$	$	$
cord-015021-pol2qm74	7897	23	log	log	NN
cord-015021-pol2qm74	7897	24	normal	normal	JJ
cord-015021-pol2qm74	7897	25	)	)	-RRB-
cord-015021-pol2qm74	7897	26	.	.	.
cord-015021-pol2qm74	7898	1	When	when	WRB
cord-015021-pol2qm74	7898	2	we	-PRON-	PRP
cord-015021-pol2qm74	7898	3	examined	examine	VBD
cord-015021-pol2qm74	7898	4	the	the	DT
cord-015021-pol2qm74	7898	5	variation	variation	NN
cord-015021-pol2qm74	7898	6	in	in	IN
cord-015021-pol2qm74	7898	7	patients	patient	NNS
cord-015021-pol2qm74	7898	8	above	above	IN
cord-015021-pol2qm74	7898	9	and	and	CC
cord-015021-pol2qm74	7898	10	below	below	IN
cord-015021-pol2qm74	7898	11	the	the	DT
cord-015021-pol2qm74	7898	12	24	24	CD
cord-015021-pol2qm74	7898	13	%	%	NN
cord-015021-pol2qm74	7898	14	risk	risk	NN
cord-015021-pol2qm74	7898	15	level	level	NN
cord-015021-pol2qm74	7898	16	with	with	IN
cord-015021-pol2qm74	7898	17	hazard	hazard	NN
cord-015021-pol2qm74	7898	18	functions	function	NNS
cord-015021-pol2qm74	7898	19	,	,	,
cord-015021-pol2qm74	7898	20	i.e.	i.e.	FW
cord-015021-pol2qm74	7898	21	,	,	,
cord-015021-pol2qm74	7898	22	their	-PRON-	PRP$
cord-015021-pol2qm74	7898	23	daily	daily	JJ
cord-015021-pol2qm74	7898	24	risk	risk	NN
cord-015021-pol2qm74	7898	25	of	of	IN
cord-015021-pol2qm74	7898	26	death	death	NN
cord-015021-pol2qm74	7898	27	during	during	IN
cord-015021-pol2qm74	7898	28	the	the	DT
cord-015021-pol2qm74	7898	29	study	study	NN
cord-015021-pol2qm74	7898	30	period	period	NN
cord-015021-pol2qm74	7898	31	,	,	,
cord-015021-pol2qm74	7898	32	we	-PRON-	PRP
cord-015021-pol2qm74	7898	33	found	find	VBD
cord-015021-pol2qm74	7898	34	that	that	IN
cord-015021-pol2qm74	7898	35	placebo	placebo	NN
cord-015021-pol2qm74	7898	36	patients	patient	NNS
cord-015021-pol2qm74	7898	37	With	with	IN
cord-015021-pol2qm74	7898	38	<	<	XX
cord-015021-pol2qm74	7898	39	24	24	CD
cord-015021-pol2qm74	7898	40	%	%	NN
cord-015021-pol2qm74	7898	41	risk	risk	NN
cord-015021-pol2qm74	7898	42	had	have	VBD
cord-015021-pol2qm74	7898	43	lltile	lltile	NNP
cord-015021-pol2qm74	7898	44	acute	acute	JJ
cord-015021-pol2qm74	7898	45	daffy	daffy	JJ
cord-015021-pol2qm74	7898	46	risk	risk	NN
cord-015021-pol2qm74	7898	47	during	during	IN
cord-015021-pol2qm74	7898	48	the	the	DT
cord-015021-pol2qm74	7898	49	hlltial	hlltial	JJ
cord-015021-pol2qm74	7898	50	two	two	CD
cord-015021-pol2qm74	7898	51	days	day	NNS
cord-015021-pol2qm74	7898	52	follawh	follawh	JJ
cord-015021-pol2qm74	7899	1	~g	~g	NNP
cord-015021-pol2qm74	7899	2	study	study	NN
cord-015021-pol2qm74	7899	3	entry	entry	NN
cord-015021-pol2qm74	7899	4	and	and	CC
cord-015021-pol2qm74	7899	5	this	this	DT
cord-015021-pol2qm74	7899	6	risk	risk	NN
cord-015021-pol2qm74	7899	7	was	be	VBD
cord-015021-pol2qm74	7899	8	little	little	RB
cord-015021-pol2qm74	7899	9	affected	affect	VBN
cord-015021-pol2qm74	7899	10	by	by	IN
cord-015021-pol2qm74	7899	11	rhIL	rhIL	NNP
cord-015021-pol2qm74	7899	12	-	-	HYPH
cord-015021-pol2qm74	7899	13	lra	lra	NNP
cord-015021-pol2qm74	7899	14	,	,	,
cord-015021-pol2qm74	7899	15	In	in	IN
cord-015021-pol2qm74	7899	16	contrast	contrast	NN
cord-015021-pol2qm74	7899	17	,	,	,
cord-015021-pol2qm74	7899	18	patients	patient	NNS
cord-015021-pol2qm74	7899	19	with	with	IN
cord-015021-pol2qm74	7899	20	>	>	XX
cord-015021-pol2qm74	7899	21	24	24	CD
cord-015021-pol2qm74	7899	22	%	%	NN
cord-015021-pol2qm74	7899	23	risk	risk	NN
cord-015021-pol2qm74	7899	24	had	have	VBD
cord-015021-pol2qm74	7899	25	high	high	JJ
cord-015021-pol2qm74	7899	26	daily	daily	JJ
cord-015021-pol2qm74	7899	27	mortality	mortality	NN
cord-015021-pol2qm74	7899	28	risks	risk	NNS
cord-015021-pol2qm74	7899	29	during	during	IN
cord-015021-pol2qm74	7899	30	the	the	DT
cord-015021-pol2qm74	7899	31	tuttlal	tuttlal	NN
cord-015021-pol2qm74	7899	32	two	two	CD
cord-015021-pol2qm74	7899	33	days	day	NNS
cord-015021-pol2qm74	7899	34	that	that	WDT
cord-015021-pol2qm74	7899	35	high	high	JJ
cord-015021-pol2qm74	7899	36	dose	dose	NN
cord-015021-pol2qm74	7899	37	rhtL	rhtL	NNPS
cord-015021-pol2qm74	7899	38	-	-	HYPH
cord-015021-pol2qm74	7899	39	lro	lro	NNP
cord-015021-pol2qm74	7899	40	substantially	substantially	RB
cord-015021-pol2qm74	7899	41	reduced	reduce	VBN
cord-015021-pol2qm74	7899	42	.	.	.
cord-015021-pol2qm74	7900	1	These	these	DT
cord-015021-pol2qm74	7900	2	results	result	NNS
cord-015021-pol2qm74	7900	3	are	be	VBP
cord-015021-pol2qm74	7900	4	compatible	compatible	JJ
cord-015021-pol2qm74	7900	5	with	with	IN
cord-015021-pol2qm74	7900	6	our	-PRON-	PRP$
cord-015021-pol2qm74	7900	7	current	current	JJ
cord-015021-pol2qm74	7900	8	understanding	understanding	NN
cord-015021-pol2qm74	7900	9	of	of	IN
cord-015021-pol2qm74	7900	10	outcome	outcome	NN
cord-015021-pol2qm74	7900	11	from	from	IN
cord-015021-pol2qm74	7900	12	sepsis	sepsis	NN
cord-015021-pol2qm74	7900	13	and	and	CC
cord-015021-pol2qm74	7900	14	the	the	DT
cord-015021-pol2qm74	7900	15	proposed	propose	VBN
cord-015021-pol2qm74	7900	16	mechanism	mechanism	NN
cord-015021-pol2qm74	7900	17	of	of	IN
cord-015021-pol2qm74	7900	18	action	action	NN
cord-015021-pol2qm74	7900	19	o£	o£	NNP
cord-015021-pol2qm74	7900	20	immunotherapy	immunotherapy	NN
cord-015021-pol2qm74	7900	21	,	,	,
cord-015021-pol2qm74	7900	22	The	the	DT
cord-015021-pol2qm74	7900	23	earliest	early	JJS
cord-015021-pol2qm74	7900	24	deaths	death	NNS
cord-015021-pol2qm74	7900	25	from	from	IN
cord-015021-pol2qm74	7900	26	sop	sop	NNP
cord-015021-pol2qm74	7900	27	sis	sis	NNP
cord-015021-pol2qm74	7900	28	are	be	VBP
cord-015021-pol2qm74	7900	29	secondary	secondary	JJ
cord-015021-pol2qm74	7900	30	to	to	IN
cord-015021-pol2qm74	7900	31	an	an	DT
cord-015021-pol2qm74	7900	32	immediate	immediate	JJ
cord-015021-pol2qm74	7900	33	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7900	34	response	response	NN
cord-015021-pol2qm74	7900	35	followed	follow	VBN
cord-015021-pol2qm74	7900	36	closely	closely	RB
cord-015021-pol2qm74	7900	37	by	by	IN
cord-015021-pol2qm74	7900	38	deaths	death	NNS
cord-015021-pol2qm74	7900	39	secondary	secondary	JJ
cord-015021-pol2qm74	7900	40	to	to	IN
cord-015021-pol2qm74	7900	41	multiple	multiple	JJ
cord-015021-pol2qm74	7900	42	organ	organ	NN
cord-015021-pol2qm74	7900	43	system	system	NN
cord-015021-pol2qm74	7900	44	failure	failure	NN
cord-015021-pol2qm74	7900	45	,	,	,
cord-015021-pol2qm74	7900	46	Later	later	JJ
cord-015021-pol2qm74	7900	47	deaths	death	NNS
cord-015021-pol2qm74	7900	48	(	(	-LRB-
cord-015021-pol2qm74	7900	49	after	after	IN
cord-015021-pol2qm74	7900	50	14	14	CD
cord-015021-pol2qm74	7900	51	days	day	NNS
cord-015021-pol2qm74	7900	52	)	)	-RRB-
cord-015021-pol2qm74	7900	53	are	be	VBP
cord-015021-pol2qm74	7900	54	not	not	RB
cord-015021-pol2qm74	7900	55	as	as	RB
cord-015021-pol2qm74	7900	56	closely	closely	RB
cord-015021-pol2qm74	7900	57	related	relate	VBN
cord-015021-pol2qm74	7900	58	to	to	IN
cord-015021-pol2qm74	7900	59	the	the	DT
cord-015021-pol2qm74	7900	60	acute	acute	JJ
cord-015021-pol2qm74	7900	61	effeete	effeete	NN
cord-015021-pol2qm74	7900	62	of	of	IN
cord-015021-pol2qm74	7900	63	the	the	DT
cord-015021-pol2qm74	7900	64	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7900	65	cascade	cascade	NN
cord-015021-pol2qm74	7900	66	.	.	.
cord-015021-pol2qm74	7901	1	Because	because	IN
cord-015021-pol2qm74	7901	2	of	of	IN
cord-015021-pol2qm74	7901	3	the	the	DT
cord-015021-pol2qm74	7901	4	timing	timing	NN
cord-015021-pol2qm74	7901	5	and	and	CC
cord-015021-pol2qm74	7901	6	action	action	NN
cord-015021-pol2qm74	7901	7	of	of	IN
cord-015021-pol2qm74	7901	8	most	most	RBS
cord-015021-pol2qm74	7901	9	proposed	propose	VBN
cord-015021-pol2qm74	7901	10	tmmunotherapy	tmmunotherapy	NNP
cord-015021-pol2qm74	7901	11	,	,	,
cord-015021-pol2qm74	7901	12	they	-PRON-	PRP
cord-015021-pol2qm74	7901	13	may	may	MD
cord-015021-pol2qm74	7901	14	be	be	VB
cord-015021-pol2qm74	7901	15	capable	capable	JJ
cord-015021-pol2qm74	7901	16	of	of	IN
cord-015021-pol2qm74	7901	17	preventing	prevent	VBG
cord-015021-pol2qm74	7901	18	mortality	mortality	NN
cord-015021-pol2qm74	7901	19	primarily	primarily	RB
cord-015021-pol2qm74	7901	20	in	in	IN
cord-015021-pol2qm74	7901	21	these	these	DT
cord-015021-pol2qm74	7901	22	initial	initial	JJ
cord-015021-pol2qm74	7901	23	two	two	CD
cord-015021-pol2qm74	7901	24	phases	phase	NNS
cord-015021-pol2qm74	7901	25	.	.	.
cord-015021-pol2qm74	7902	1	In	in	IN
cord-015021-pol2qm74	7902	2	this	this	DT
cord-015021-pol2qm74	7902	3	study	study	NN
cord-015021-pol2qm74	7902	4	,	,	,
cord-015021-pol2qm74	7902	5	an	an	DT
cord-015021-pol2qm74	7902	6	independent	independent	JJ
cord-015021-pol2qm74	7902	7	predicted	predict	VBD
cord-015021-pol2qm74	7902	8	risk	risk	NN
cord-015021-pol2qm74	7902	9	of	of	IN
cord-015021-pol2qm74	7902	10	mortality	mortality	NN
cord-015021-pol2qm74	7902	11	reflected	reflect	VBD
cord-015021-pol2qm74	7902	12	this	this	DT
cord-015021-pol2qm74	7902	13	mortality	mortality	NN
cord-015021-pol2qm74	7902	14	pattern	pattern	NN
cord-015021-pol2qm74	7902	15	ned	ned	NNP
cord-015021-pol2qm74	7902	16	illustrated	illustrate	VBD
cord-015021-pol2qm74	7902	17	the	the	DT
cord-015021-pol2qm74	7902	18	potential	potential	JJ
cord-015021-pol2qm74	7902	19	benefit	benefit	NN
cord-015021-pol2qm74	7902	20	of	of	IN
cord-015021-pol2qm74	7902	21	immtmotherapy	immtmotherapy	NNP
cord-015021-pol2qm74	7902	22	.	.	.
cord-015021-pol2qm74	7903	1	Use	use	NN
cord-015021-pol2qm74	7903	2	of	of	IN
cord-015021-pol2qm74	7903	3	a	a	DT
cord-015021-pol2qm74	7903	4	predicted	predict	VBN
cord-015021-pol2qm74	7903	5	risk	risk	NN
cord-015021-pol2qm74	7903	6	of	of	IN
cord-015021-pol2qm74	7903	7	mortality	mortality	NN
cord-015021-pol2qm74	7903	8	in	in	IN
cord-015021-pol2qm74	7903	9	the	the	DT
cord-015021-pol2qm74	7903	10	design	design	NN
cord-015021-pol2qm74	7903	11	and	and	CC
cord-015021-pol2qm74	7903	12	analysis	analysis	NN
cord-015021-pol2qm74	7903	13	of	of	IN
cord-015021-pol2qm74	7903	14	clinical	clinical	JJ
cord-015021-pol2qm74	7903	15	trials	trial	NNS
cord-015021-pol2qm74	7903	16	could	could	MD
cord-015021-pol2qm74	7903	17	improve	improve	VB
cord-015021-pol2qm74	7903	18	our	-PRON-	PRP$
cord-015021-pol2qm74	7903	19	understanding	understanding	NN
cord-015021-pol2qm74	7903	20	of	of	IN
cord-015021-pol2qm74	7903	21	the	the	DT
cord-015021-pol2qm74	7903	22	clinical	clinical	JJ
cord-015021-pol2qm74	7903	23	benefit	benefit	NN
cord-015021-pol2qm74	7903	24	of	of	IN
cord-015021-pol2qm74	7903	25	these	these	DT
cord-015021-pol2qm74	7903	26	new	new	JJ
cord-015021-pol2qm74	7903	27	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	7903	28	approaches	approach	NNS
cord-015021-pol2qm74	7903	29	.	.	.
cord-015021-pol2qm74	7904	1	The	the	DT
cord-015021-pol2qm74	7904	2	systemic	systemic	JJ
cord-015021-pol2qm74	7904	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7904	4	response	response	NN
cord-015021-pol2qm74	7904	5	syndrome	syndrome	NN
cord-015021-pol2qm74	7904	6	(	(	-LRB-
cord-015021-pol2qm74	7904	7	SIRS	SIRS	NNP
cord-015021-pol2qm74	7904	8	)	)	-RRB-
cord-015021-pol2qm74	7904	9	is	be	VBZ
cord-015021-pol2qm74	7904	10	a	a	DT
cord-015021-pol2qm74	7904	11	term	term	NN
cord-015021-pol2qm74	7904	12	recently	recently	RB
cord-015021-pol2qm74	7904	13	proposed	propose	VBN
cord-015021-pol2qm74	7904	14	to	to	TO
cord-015021-pol2qm74	7904	15	describe	describe	VB
cord-015021-pol2qm74	7904	16	patients	patient	NNS
cord-015021-pol2qm74	7904	17	with	with	IN
cord-015021-pol2qm74	7904	18	systemic	systemic	JJ
cord-015021-pol2qm74	7904	19	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7904	20	responses	response	NNS
cord-015021-pol2qm74	7904	21	to	to	IN
cord-015021-pol2qm74	7904	22	insults	insult	NNS
cord-015021-pol2qm74	7904	23	such	such	JJ
cord-015021-pol2qm74	7904	24	as	as	IN
cord-015021-pol2qm74	7904	25	infections	infection	NNS
cord-015021-pol2qm74	7904	26	(	(	-LRB-
cord-015021-pol2qm74	7904	27	sepsis	sepsis	NN
cord-015021-pol2qm74	7904	28	)	)	-RRB-
cord-015021-pol2qm74	7904	29	,	,	,
cord-015021-pol2qm74	7904	30	trauma	trauma	NN
cord-015021-pol2qm74	7904	31	,	,	,
cord-015021-pol2qm74	7904	32	burns	burn	NNS
cord-015021-pol2qm74	7904	33	,	,	,
cord-015021-pol2qm74	7904	34	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	7904	35	,	,	,
cord-015021-pol2qm74	7904	36	and	and	CC
cord-015021-pol2qm74	7904	37	other	other	JJ
cord-015021-pol2qm74	7904	38	initiating	initiate	VBG
cord-015021-pol2qm74	7904	39	events	event	NNS
cord-015021-pol2qm74	7904	40	.	.	.
cord-015021-pol2qm74	7905	1	Patients	patient	NNS
cord-015021-pol2qm74	7905	2	with	with	IN
cord-015021-pol2qm74	7905	3	SIRS	SIRS	NNP
cord-015021-pol2qm74	7905	4	may	may	MD
cord-015021-pol2qm74	7905	5	have	have	VB
cord-015021-pol2qm74	7905	6	similar	similar	JJ
cord-015021-pol2qm74	7905	7	activation	activation	NN
cord-015021-pol2qm74	7905	8	of	of	IN
cord-015021-pol2qm74	7905	9	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	7905	10	mediators	mediator	NNS
cord-015021-pol2qm74	7905	11	and	and	CC
cord-015021-pol2qm74	7905	12	similar	similar	JJ
cord-015021-pol2qm74	7905	13	outcomes	outcome	NNS
cord-015021-pol2qm74	7905	14	independent	independent	JJ
cord-015021-pol2qm74	7905	15	of	of	IN
cord-015021-pol2qm74	7905	16	the	the	DT
cord-015021-pol2qm74	7905	17	initiating	initiate	VBG
cord-015021-pol2qm74	7905	18	event	event	NN
cord-015021-pol2qm74	7905	19	.	.	.
cord-015021-pol2qm74	7906	1	These	these	DT
cord-015021-pol2qm74	7906	2	outcomes	outcome	NNS
cord-015021-pol2qm74	7906	3	include	include	VBP
cord-015021-pol2qm74	7906	4	organ	organ	NN
cord-015021-pol2qm74	7906	5	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7906	6	and	and	CC
cord-015021-pol2qm74	7906	7	failure	failure	NN
cord-015021-pol2qm74	7906	8	,	,	,
cord-015021-pol2qm74	7906	9	shock	shock	NN
cord-015021-pol2qm74	7906	10	,	,	,
cord-015021-pol2qm74	7906	11	and	and	CC
cord-015021-pol2qm74	7906	12	death	death	NN
cord-015021-pol2qm74	7906	13	.	.	.
cord-015021-pol2qm74	7907	1	Challenges	challenge	NNS
cord-015021-pol2qm74	7907	2	to	to	IN
cord-015021-pol2qm74	7907	3	the	the	DT
cord-015021-pol2qm74	7907	4	successful	successful	JJ
cord-015021-pol2qm74	7907	5	conduct	conduct	NN
cord-015021-pol2qm74	7907	6	of	of	IN
cord-015021-pol2qm74	7907	7	clinical	clinical	JJ
cord-015021-pol2qm74	7907	8	trials	trial	NNS
cord-015021-pol2qm74	7907	9	in	in	IN
cord-015021-pol2qm74	7907	10	SIRS	sir	NNS
cord-015021-pol2qm74	7907	11	include	include	VBP
cord-015021-pol2qm74	7907	12	the	the	DT
cord-015021-pol2qm74	7907	13	complexity	complexity	NN
cord-015021-pol2qm74	7907	14	of	of	IN
cord-015021-pol2qm74	7907	15	illness	illness	NN
cord-015021-pol2qm74	7907	16	in	in	IN
cord-015021-pol2qm74	7907	17	these	these	DT
cord-015021-pol2qm74	7907	18	patients	patient	NNS
cord-015021-pol2qm74	7907	19	and	and	CC
cord-015021-pol2qm74	7907	20	the	the	DT
cord-015021-pol2qm74	7907	21	important	important	JJ
cord-015021-pol2qm74	7907	22	--	--	:
cord-015021-pol2qm74	7907	23	but	but	CC
cord-015021-pol2qm74	7907	24	limited	limited	JJ
cord-015021-pol2qm74	7907	25	--	--	:
cord-015021-pol2qm74	7907	26	clinical	clinical	JJ
cord-015021-pol2qm74	7907	27	benefits	benefit	NNS
cord-015021-pol2qm74	7907	28	of	of	IN
cord-015021-pol2qm74	7907	29	novel	novel	JJ
cord-015021-pol2qm74	7907	30	compounds	compound	NNS
cord-015021-pol2qm74	7907	31	that	that	WDT
cord-015021-pol2qm74	7907	32	may	may	MD
cord-015021-pol2qm74	7907	33	be	be	VB
cord-015021-pol2qm74	7907	34	limited	limit	VBN
cord-015021-pol2qm74	7907	35	to	to	IN
cord-015021-pol2qm74	7907	36	selected	select	VBN
cord-015021-pol2qm74	7907	37	patient	patient	JJ
cord-015021-pol2qm74	7907	38	subsets	subset	NNS
cord-015021-pol2qm74	7907	39	.	.	.
cord-015021-pol2qm74	7908	1	Addressing	address	VBG
cord-015021-pol2qm74	7908	2	these	these	DT
cord-015021-pol2qm74	7908	3	challenges	challenge	NNS
cord-015021-pol2qm74	7908	4	will	will	MD
cord-015021-pol2qm74	7908	5	require	require	VB
cord-015021-pol2qm74	7908	6	new	new	JJ
cord-015021-pol2qm74	7908	7	tools	tool	NNS
cord-015021-pol2qm74	7908	8	and	and	CC
cord-015021-pol2qm74	7908	9	approaches	approach	NNS
cord-015021-pol2qm74	7908	10	.	.	.
cord-015021-pol2qm74	7909	1	These	these	DT
cord-015021-pol2qm74	7909	2	will	will	MD
cord-015021-pol2qm74	7909	3	include	include	VB
cord-015021-pol2qm74	7909	4	more	more	RBR
cord-015021-pol2qm74	7909	5	sensitive	sensitive	JJ
cord-015021-pol2qm74	7909	6	and	and	CC
cord-015021-pol2qm74	7909	7	appropriate	appropriate	JJ
cord-015021-pol2qm74	7909	8	endpoints	endpoint	NNS
cord-015021-pol2qm74	7909	9	,	,	,
cord-015021-pol2qm74	7909	10	and	and	CC
cord-015021-pol2qm74	7909	11	the	the	DT
cord-015021-pol2qm74	7909	12	use	use	NN
cord-015021-pol2qm74	7909	13	of	of	IN
cord-015021-pol2qm74	7909	14	methods	method	NNS
cord-015021-pol2qm74	7909	15	such	such	JJ
cord-015021-pol2qm74	7909	16	as	as	IN
cord-015021-pol2qm74	7909	17	baseline	baseline	JJ
cord-015021-pol2qm74	7909	18	risk	risk	NN
cord-015021-pol2qm74	7909	19	adjustment	adjustment	NN
cord-015021-pol2qm74	7909	20	,	,	,
cord-015021-pol2qm74	7909	21	to	to	TO
cord-015021-pol2qm74	7909	22	allow	allow	VB
cord-015021-pol2qm74	7909	23	detection	detection	NN
cord-015021-pol2qm74	7909	24	of	of	IN
cord-015021-pol2qm74	7909	25	drug	drug	NN
cord-015021-pol2qm74	7909	26	risk	risk	NN
cord-015021-pol2qm74	7909	27	interactions	interaction	NNS
cord-015021-pol2qm74	7909	28	not	not	RB
cord-015021-pol2qm74	7909	29	captured	capture	VBN
cord-015021-pol2qm74	7909	30	adequately	adequately	RB
cord-015021-pol2qm74	7909	31	by	by	IN
cord-015021-pol2qm74	7909	32	categorical	categorical	JJ
cord-015021-pol2qm74	7909	33	definitions	definition	NNS
cord-015021-pol2qm74	7909	34	,	,	,
cord-015021-pol2qm74	7909	35	such	such	JJ
cord-015021-pol2qm74	7909	36	as	as	IN
cord-015021-pol2qm74	7909	37	sepsis	sepsis	NN
cord-015021-pol2qm74	7909	38	syndrome	syndrome	NN
cord-015021-pol2qm74	7909	39	.	.	.
cord-015021-pol2qm74	7910	1	On	on	IN
cord-015021-pol2qm74	7910	2	the	the	DT
cord-015021-pol2qm74	7910	3	basis	basis	NN
cord-015021-pol2qm74	7910	4	of	of	IN
cord-015021-pol2qm74	7910	5	supportive	supportive	JJ
cord-015021-pol2qm74	7910	6	preclinical	preclinical	JJ
cord-015021-pol2qm74	7910	7	and	and	CC
cord-015021-pol2qm74	7910	8	Phase	phase	NN
cord-015021-pol2qm74	7910	9	I	-PRON-	PRP
cord-015021-pol2qm74	7910	10	safety	safety	NN
cord-015021-pol2qm74	7910	11	studies	study	NNS
cord-015021-pol2qm74	7910	12	,	,	,
cord-015021-pol2qm74	7910	13	we	-PRON-	PRP
cord-015021-pol2qm74	7910	14	have	have	VBP
cord-015021-pol2qm74	7910	15	initiated	initiate	VBN
cord-015021-pol2qm74	7910	16	Phase	Phase	NNP
cord-015021-pol2qm74	7910	17	II	II	NNP
cord-015021-pol2qm74	7910	18	clinical	clinical	JJ
cord-015021-pol2qm74	7910	19	trials	trial	NNS
cord-015021-pol2qm74	7910	20	of	of	IN
cord-015021-pol2qm74	7910	21	a	a	DT
cord-015021-pol2qm74	7910	22	novel	novel	JJ
cord-015021-pol2qm74	7910	23	bradykinin	bradykinin	NN
cord-015021-pol2qm74	7910	24	antagonist	antagonist	NN
cord-015021-pol2qm74	7910	25	,	,	,
cord-015021-pol2qm74	7910	26	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	7910	27	,	,	,
cord-015021-pol2qm74	7910	28	in	in	IN
cord-015021-pol2qm74	7910	29	four	four	CD
cord-015021-pol2qm74	7910	30	SIRS	SIRS	NNP
cord-015021-pol2qm74	7910	31	subcategofies	subcategofie	NNS
cord-015021-pol2qm74	7910	32	:	:	:
cord-015021-pol2qm74	7910	33	sepsis	sepsis	NN
cord-015021-pol2qm74	7910	34	,	,	,
cord-015021-pol2qm74	7910	35	multiple	multiple	JJ
cord-015021-pol2qm74	7910	36	trauma	trauma	NN
cord-015021-pol2qm74	7910	37	,	,	,
cord-015021-pol2qm74	7910	38	burns	burn	NNS
cord-015021-pol2qm74	7910	39	,	,	,
cord-015021-pol2qm74	7910	40	and	and	CC
cord-015021-pol2qm74	7910	41	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	7910	42	.	.	.
cord-015021-pol2qm74	7911	1	Each	each	DT
cord-015021-pol2qm74	7911	2	of	of	IN
cord-015021-pol2qm74	7911	3	these	these	DT
cord-015021-pol2qm74	7911	4	studies	study	NNS
cord-015021-pol2qm74	7911	5	is	be	VBZ
cord-015021-pol2qm74	7911	6	designed	design	VBN
cord-015021-pol2qm74	7911	7	to	to	TO
cord-015021-pol2qm74	7911	8	measure	measure	VB
cord-015021-pol2qm74	7911	9	the	the	DT
cord-015021-pol2qm74	7911	10	effect	effect	NN
cord-015021-pol2qm74	7911	11	of	of	IN
cord-015021-pol2qm74	7911	12	CP-0127	cp-0127	NN
cord-015021-pol2qm74	7911	13	on	on	IN
cord-015021-pol2qm74	7911	14	mortality	mortality	NN
cord-015021-pol2qm74	7911	15	,	,	,
cord-015021-pol2qm74	7911	16	organ	organ	NN
cord-015021-pol2qm74	7911	17	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7911	18	and	and	CC
cord-015021-pol2qm74	7911	19	failure	failure	NN
cord-015021-pol2qm74	7911	20	,	,	,
cord-015021-pol2qm74	7911	21	and	and	CC
cord-015021-pol2qm74	7911	22	activation	activation	NN
cord-015021-pol2qm74	7911	23	of	of	IN
cord-015021-pol2qm74	7911	24	mediators	mediator	NNS
cord-015021-pol2qm74	7911	25	.	.	.
cord-015021-pol2qm74	7912	1	In	in	IN
cord-015021-pol2qm74	7912	2	addition	addition	NN
cord-015021-pol2qm74	7912	3	to	to	IN
cord-015021-pol2qm74	7912	4	investigating	investigate	VBG
cord-015021-pol2qm74	7912	5	rates	rate	NNS
cord-015021-pol2qm74	7912	6	of	of	IN
cord-015021-pol2qm74	7912	7	organ	organ	NN
cord-015021-pol2qm74	7912	8	failure	failure	NN
cord-015021-pol2qm74	7912	9	using	use	VBG
cord-015021-pol2qm74	7912	10	standard	standard	JJ
cord-015021-pol2qm74	7912	11	definitions	definition	NNS
cord-015021-pol2qm74	7912	12	--	--	:
cord-015021-pol2qm74	7912	13	a	a	DT
cord-015021-pol2qm74	7912	14	new	new	JJ
cord-015021-pol2qm74	7912	15	endpoint	endpoint	NN
cord-015021-pol2qm74	7912	16	--	--	:
cord-015021-pol2qm74	7912	17	a	a	DT
cord-015021-pol2qm74	7912	18	continuous	continuous	JJ
cord-015021-pol2qm74	7912	19	summary	summary	NN
cord-015021-pol2qm74	7912	20	measure	measure	NN
cord-015021-pol2qm74	7912	21	of	of	IN
cord-015021-pol2qm74	7912	22	organ	organ	NN
cord-015021-pol2qm74	7912	23	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7912	24	(	(	-LRB-
cord-015021-pol2qm74	7912	25	the	the	DT
cord-015021-pol2qm74	7912	26	Acute	Acute	NNP
cord-015021-pol2qm74	7912	27	Physiology	Physiology	NNP
cord-015021-pol2qm74	7912	28	Score	Score	NNP
cord-015021-pol2qm74	7912	29	of	of	IN
cord-015021-pol2qm74	7912	30	APACHE	APACHE	NNP
cord-015021-pol2qm74	7912	31	TM	TM	NNP
cord-015021-pol2qm74	7912	32	III	III	NNP
cord-015021-pol2qm74	7912	33	)	)	-RRB-
cord-015021-pol2qm74	7912	34	is	be	VBZ
cord-015021-pol2qm74	7912	35	being	be	VBG
cord-015021-pol2qm74	7912	36	used	use	VBN
cord-015021-pol2qm74	7912	37	to	to	TO
cord-015021-pol2qm74	7912	38	quantify	quantify	VB
cord-015021-pol2qm74	7912	39	the	the	DT
cord-015021-pol2qm74	7912	40	degree	degree	NN
cord-015021-pol2qm74	7912	41	of	of	IN
cord-015021-pol2qm74	7912	42	organ	organ	NN
cord-015021-pol2qm74	7912	43	dysfunction	dysfunction	NN
cord-015021-pol2qm74	7912	44	and	and	CC
cord-015021-pol2qm74	7912	45	the	the	DT
cord-015021-pol2qm74	7912	46	speed	speed	NN
cord-015021-pol2qm74	7912	47	and	and	CC
cord-015021-pol2qm74	7912	48	pattern	pattern	NN
cord-015021-pol2qm74	7912	49	of	of	IN
cord-015021-pol2qm74	7912	50	recovery	recovery	NN
cord-015021-pol2qm74	7912	51	of	of	IN
cord-015021-pol2qm74	7912	52	physiologic	physiologic	JJ
cord-015021-pol2qm74	7912	53	stability	stability	NN
cord-015021-pol2qm74	7912	54	.	.	.
cord-015021-pol2qm74	7913	1	In	in	IN
cord-015021-pol2qm74	7913	2	the	the	DT
cord-015021-pol2qm74	7913	3	sepsis	sepsis	NN
cord-015021-pol2qm74	7913	4	study	study	NN
cord-015021-pol2qm74	7913	5	,	,	,
cord-015021-pol2qm74	7913	6	another	another	DT
cord-015021-pol2qm74	7913	7	new	new	JJ
cord-015021-pol2qm74	7913	8	approach	approach	NN
cord-015021-pol2qm74	7913	9	--	--	:
cord-015021-pol2qm74	7913	10	a	a	DT
cord-015021-pol2qm74	7913	11	study	study	NN
cord-015021-pol2qm74	7913	12	specific	specific	JJ
cord-015021-pol2qm74	7913	13	risk	risk	NN
cord-015021-pol2qm74	7913	14	model	model	NN
cord-015021-pol2qm74	7913	15	based	base	VBN
cord-015021-pol2qm74	7913	16	on	on	IN
cord-015021-pol2qm74	7913	17	the	the	DT
cord-015021-pol2qm74	7913	18	APACHE	APACHE	NNP
cord-015021-pol2qm74	7913	19	Ill	Ill	NNP
cord-015021-pol2qm74	7913	20	database	database	NN
cord-015021-pol2qm74	7913	21	--	--	:
cord-015021-pol2qm74	7913	22	has	have	VBZ
cord-015021-pol2qm74	7913	23	been	be	VBN
cord-015021-pol2qm74	7913	24	developed	develop	VBN
cord-015021-pol2qm74	7913	25	which	which	WDT
cord-015021-pol2qm74	7913	26	will	will	MD
cord-015021-pol2qm74	7913	27	be	be	VB
cord-015021-pol2qm74	7913	28	used	use	VBN
cord-015021-pol2qm74	7913	29	to	to	TO
cord-015021-pol2qm74	7913	30	assign	assign	VB
cord-015021-pol2qm74	7913	31	a	a	DT
cord-015021-pol2qm74	7913	32	pre	pre	JJ
cord-015021-pol2qm74	7913	33	-	-	JJ
cord-015021-pol2qm74	7913	34	treatment	treatment	JJ
cord-015021-pol2qm74	7913	35	baseline	baseline	JJ
cord-015021-pol2qm74	7913	36	risk	risk	NN
cord-015021-pol2qm74	7913	37	to	to	IN
cord-015021-pol2qm74	7913	38	each	each	DT
cord-015021-pol2qm74	7913	39	patient	patient	NN
cord-015021-pol2qm74	7913	40	enrolled	enrol	VBN
cord-015021-pol2qm74	7913	41	.	.	.
cord-015021-pol2qm74	7914	1	The	the	DT
cord-015021-pol2qm74	7914	2	primary	primary	JJ
cord-015021-pol2qm74	7914	3	outcome	outcome	NN
cord-015021-pol2qm74	7914	4	variable	variable	NN
cord-015021-pol2qm74	7914	5	will	will	MD
cord-015021-pol2qm74	7914	6	be	be	VB
cord-015021-pol2qm74	7914	7	risk	risk	NN
cord-015021-pol2qm74	7914	8	adjusted	adjust	VBN
cord-015021-pol2qm74	7914	9	survival	survival	NN
cord-015021-pol2qm74	7914	10	time	time	NN
cord-015021-pol2qm74	7914	11	to	to	IN
cord-015021-pol2qm74	7914	12	28	28	CD
cord-015021-pol2qm74	7914	13	days	day	NNS
cord-015021-pol2qm74	7914	14	.	.	.
cord-015021-pol2qm74	7915	1	This	this	DT
cord-015021-pol2qm74	7915	2	type	type	NN
cord-015021-pol2qm74	7915	3	of	of	IN
cord-015021-pol2qm74	7915	4	risk	risk	NN
cord-015021-pol2qm74	7915	5	-	-	HYPH
cord-015021-pol2qm74	7915	6	adjusted	adjust	VBN
cord-015021-pol2qm74	7915	7	analysis	analysis	NN
cord-015021-pol2qm74	7915	8	may	may	MD
cord-015021-pol2qm74	7915	9	allow	allow	VB
cord-015021-pol2qm74	7915	10	for	for	IN
cord-015021-pol2qm74	7915	11	more	more	RBR
cord-015021-pol2qm74	7915	12	efficient	efficient	JJ
cord-015021-pol2qm74	7915	13	and	and	CC
cord-015021-pol2qm74	7915	14	powerful	powerful	JJ
cord-015021-pol2qm74	7915	15	trials	trial	NNS
cord-015021-pol2qm74	7915	16	and	and	CC
cord-015021-pol2qm74	7915	17	more	more	RBR
cord-015021-pol2qm74	7915	18	accurate	accurate	JJ
cord-015021-pol2qm74	7915	19	and	and	CC
cord-015021-pol2qm74	7915	20	useful	useful	JJ
cord-015021-pol2qm74	7915	21	indications	indication	NNS
cord-015021-pol2qm74	7915	22	for	for	IN
cord-015021-pol2qm74	7915	23	use	use	NN
cord-015021-pol2qm74	7915	24	.	.	.
cord-015021-pol2qm74	7916	1	Study	study	NN
cord-015021-pol2qm74	7916	2	PurPose	PurPose	NNP
cord-015021-pol2qm74	7916	3	:	:	:
cord-015021-pol2qm74	7917	1	In	in	IN
cord-015021-pol2qm74	7917	2	post	post	JJ
cord-015021-pol2qm74	7917	3	-	-	JJ
cord-015021-pol2qm74	7917	4	cardiac	cardiac	JJ
cord-015021-pol2qm74	7917	5	surgical	surgical	JJ
cord-015021-pol2qm74	7917	6	patients	patient	NNS
cord-015021-pol2qm74	7917	7	(	(	-LRB-
cord-015021-pol2qm74	7917	8	pat	pat	NNP
cord-015021-pol2qm74	7917	9	.	.	.
cord-015021-pol2qm74	7917	10	)	)	-RRB-
cord-015021-pol2qm74	7917	11	at	at	IN
cord-015021-pol2qm74	7917	12	risk	risk	NN
cord-015021-pol2qm74	7917	13	for	for	IN
cord-015021-pol2qm74	7917	14	sepsis	sepsis	NN
cord-015021-pol2qm74	7917	15	,	,	,
cord-015021-pol2qm74	7917	16	the	the	DT
cord-015021-pol2qm74	7917	17	efficacy	efficacy	NN
cord-015021-pol2qm74	7917	18	of	of	IN
cord-015021-pol2qm74	7917	19	early	early	JJ
cord-015021-pol2qm74	7917	20	i.v	i.v	NNP
cord-015021-pol2qm74	7917	21	.	.	.
cord-015021-pol2qm74	7917	22	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	7917	23	(	(	-LRB-
cord-015021-pol2qm74	7917	24	Ig	Ig	NNP
cord-015021-pol2qm74	7917	25	)	)	-RRB-
cord-015021-pol2qm74	7917	26	treatment	treatment	NN
cord-015021-pol2qm74	7917	27	was	be	VBD
cord-015021-pol2qm74	7917	28	compared	compare	VBN
cord-015021-pol2qm74	7917	29	to	to	IN
cord-015021-pol2qm74	7917	30	a	a	DT
cord-015021-pol2qm74	7917	31	matching	match	VBG
cord-015021-pol2qm74	7917	32	historical	historical	JJ
cord-015021-pol2qm74	7917	33	control	control	NN
cord-015021-pol2qm74	7917	34	(	(	-LRB-
cord-015021-pol2qm74	7917	35	con	con	NN
cord-015021-pol2qm74	7917	36	.	.	.
cord-015021-pol2qm74	7917	37	)	)	-RRB-
cord-015021-pol2qm74	7917	38	population	population	NN
cord-015021-pol2qm74	7917	39	.	.	.
cord-015021-pol2qm74	7918	1	Postoperative	postoperative	JJ
cord-015021-pol2qm74	7918	2	risk	risk	NN
cord-015021-pol2qm74	7918	3	assessment	assessment	NN
cord-015021-pol2qm74	7918	4	:	:	:
cord-015021-pol2qm74	7919	1	Using	use	VBG
cord-015021-pol2qm74	7919	2	APACHE	APACHE	NNP
cord-015021-pol2qm74	7919	3	II	II	NNP
cord-015021-pol2qm74	7919	4	scores	score	NNS
cord-015021-pol2qm74	7919	5	LAP	LAP	NNP
cord-015021-pol2qm74	7919	6	)	)	-RRB-
cord-015021-pol2qm74	7919	7	(	(	-LRB-
cord-015021-pol2qm74	7919	8	first	first	JJ
cord-015021-pol2qm74	7919	9	postoperative	postoperative	JJ
cord-015021-pol2qm74	7919	10	[	[	-LRB-
cord-015021-pol2qm74	7919	11	pop	pop	NN
cord-015021-pol2qm74	7919	12	.	.	.
cord-015021-pol2qm74	7919	13	]	]	-RRB-
cord-015021-pol2qm74	7920	1	day	day	NN
cord-015021-pol2qm74	7920	2	)	)	-RRB-
cord-015021-pol2qm74	7920	3	in	in	IN
cord-015021-pol2qm74	7920	4	a	a	DT
cord-015021-pol2qm74	7920	5	pilot	pilot	NN
cord-015021-pol2qm74	7920	6	study	study	NN
cord-015021-pol2qm74	7920	7	phase	phase	NN
cord-015021-pol2qm74	7920	8	,	,	,
cord-015021-pol2qm74	7920	9	we	-PRON-	PRP
cord-015021-pol2qm74	7920	10	were	be	VBD
cord-015021-pol2qm74	7920	11	able	able	JJ
cord-015021-pol2qm74	7920	12	to	to	TO
cord-015021-pol2qm74	7920	13	differentiate	differentiate	VB
cord-015021-pol2qm74	7920	14	between	between	IN
cord-015021-pol2qm74	7920	15	the	the	DT
cord-015021-pol2qm74	7920	16	large	large	JJ
cord-015021-pol2qm74	7920	17	population	population	NN
cord-015021-pol2qm74	7920	18	(	(	-LRB-
cord-015021-pol2qm74	7920	19	95.2	95.2	CD
cord-015021-pol2qm74	7920	20	%	%	NN
cord-015021-pol2qm74	7920	21	)	)	-RRB-
cord-015021-pol2qm74	7920	22	of	of	IN
cord-015021-pol2qm74	7920	23	pop	pop	NN
cord-015021-pol2qm74	7920	24	.	.	.
cord-015021-pol2qm74	7921	1	low	low	JJ
cord-015021-pol2qm74	7921	2	-	-	HYPH
cord-015021-pol2qm74	7921	3	risk	risk	NN
cord-015021-pol2qm74	7921	4	pat	pat	NN
cord-015021-pol2qm74	7921	5	.	.	.
cord-015021-pol2qm74	7922	1	(	(	-LRB-
cord-015021-pol2qm74	7922	2	AP	AP	NNP
cord-015021-pol2qm74	7922	3	<	<	XX
cord-015021-pol2qm74	7922	4	19	19	CD
cord-015021-pol2qm74	7922	5	;	;	:
cord-015021-pol2qm74	7922	6	mortality	mortality	NN
cord-015021-pol2qm74	7922	7	:	:	:
cord-015021-pol2qm74	7922	8	1	1	CD
cord-015021-pol2qm74	7922	9	%	%	NN
cord-015021-pol2qm74	7922	10	)	)	-RRB-
cord-015021-pol2qm74	7922	11	and	and	CC
cord-015021-pol2qm74	7922	12	the	the	DT
cord-015021-pol2qm74	7922	13	small	small	JJ
cord-015021-pol2qm74	7922	14	groups	group	NNS
cord-015021-pol2qm74	7922	15	of	of	IN
cord-015021-pol2qm74	7922	16	pop	pop	NN
cord-015021-pol2qm74	7922	17	.	.	.
cord-015021-pol2qm74	7923	1	pat	pat	NNP
cord-015021-pol2qm74	7923	2	.	.	.
cord-015021-pol2qm74	7924	1	at	at	IN
cord-015021-pol2qm74	7924	2	risk	risk	NN
cord-015021-pol2qm74	7925	1	LAP=	lap=	CD
cord-015021-pol2qm74	7925	2	19	19	CD
cord-015021-pol2qm74	7925	3	-	-	SYM
cord-015021-pol2qm74	7925	4	23	23	CD
cord-015021-pol2qm74	7925	5	)	)	-RRB-
cord-015021-pol2qm74	7925	6	and	and	CC
cord-015021-pol2qm74	7925	7	high	high	JJ
cord-015021-pol2qm74	7925	8	risk	risk	NN
cord-015021-pol2qm74	7925	9	LAP_24	LAP_24	NNP
cord-015021-pol2qm74	7925	10	)	)	-RRB-
cord-015021-pol2qm74	7925	11	with	with	IN
cord-015021-pol2qm74	7925	12	a	a	DT
cord-015021-pol2qm74	7925	13	significantly	significantly	RB
cord-015021-pol2qm74	7925	14	higher	high	JJR
cord-015021-pol2qm74	7925	15	mortality	mortality	NN
cord-015021-pol2qm74	7925	16	(	(	-LRB-
cord-015021-pol2qm74	7925	17	14	14	CD
cord-015021-pol2qm74	7925	18	%	%	NN
cord-015021-pol2qm74	7925	19	and	and	CC
cord-015021-pol2qm74	7925	20	76	76	CD
cord-015021-pol2qm74	7925	21	%	%	NN
cord-015021-pol2qm74	7925	22	,	,	,
cord-015021-pol2qm74	7925	23	mainly	mainly	RB
cord-015021-pol2qm74	7925	24	due	due	IN
cord-015021-pol2qm74	7925	25	to	to	IN
cord-015021-pol2qm74	7925	26	sepsis	sepsis	NN
cord-015021-pol2qm74	7925	27	)	)	-RRB-
cord-015021-pol2qm74	7925	28	.	.	.
cord-015021-pol2qm74	7926	1	Subsequently	subsequently	RB
cord-015021-pol2qm74	7926	2	,	,	,
cord-015021-pol2qm74	7926	3	among	among	IN
cord-015021-pol2qm74	7926	4	1341	1341	CD
cord-015021-pol2qm74	7926	5	consecutive	consecutive	JJ
cord-015021-pol2qm74	7926	6	pop	pop	NN
cord-015021-pol2qm74	7926	7	.	.	.
cord-015021-pol2qm74	7927	1	pat	pat	NNP
cord-015021-pol2qm74	7927	2	.	.	.
cord-015021-pol2qm74	7928	1	we	-PRON-	PRP
cord-015021-pol2qm74	7928	2	prospectively	prospectively	RB
cord-015021-pol2qm74	7928	3	identified	identify	VBD
cord-015021-pol2qm74	7928	4	and	and	CC
cord-015021-pol2qm74	7928	5	treated	treat	VBD
cord-015021-pol2qm74	7928	6	these	these	DT
cord-015021-pol2qm74	7928	7	pat	pat	NN
cord-015021-pol2qm74	7928	8	.	.	.
cord-015021-pol2qm74	7929	1	Iq	Iq	NNP
cord-015021-pol2qm74	7929	2	treatment	treatment	NN
cord-015021-pol2qm74	7929	3	reqimens	reqimens	NNP
cord-015021-pol2qm74	7929	4	:	:	:
cord-015021-pol2qm74	7930	1	First	first	JJ
cord-015021-pol2qm74	7930	2	study	study	NN
cord-015021-pol2qm74	7930	3	period	period	NN
cord-015021-pol2qm74	7930	4	(	(	-LRB-
cord-015021-pol2qm74	7930	5	n	n	NN
cord-015021-pol2qm74	7930	6	=	=	SYM
cord-015021-pol2qm74	7930	7	41	41	CD
cord-015021-pol2qm74	7930	8	)	)	-RRB-
cord-015021-pol2qm74	7930	9	:	:	:
cord-015021-pol2qm74	7931	1	(	(	-LRB-
cord-015021-pol2qm74	7931	2	gG	gG	NNP
cord-015021-pol2qm74	7932	1	(	(	-LRB-
cord-015021-pol2qm74	7932	2	Psomaglobin	Psomaglobin	NNP
cord-015021-pol2qm74	7932	3	N	N	NNP
cord-015021-pol2qm74	7932	4	a	a	NNP
cord-015021-pol2qm74	7932	5	,	,	,
cord-015021-pol2qm74	7932	6	Tropon	Tropon	NNP
cord-015021-pol2qm74	7932	7	Biologische	Biologische	NNP
cord-015021-pol2qm74	7932	8	Pr	Pr	NNP
cord-015021-pol2qm74	7932	9	~	~	NNP
cord-015021-pol2qm74	7932	10	parate	parate	NN
cord-015021-pol2qm74	7932	11	,	,	,
cord-015021-pol2qm74	7932	12	Cologne	Cologne	NNP
cord-015021-pol2qm74	7932	13	,	,	,
cord-015021-pol2qm74	7932	14	FRG	FRG	NNP
cord-015021-pol2qm74	7932	15	,	,	,
cord-015021-pol2qm74	7932	16	day	day	NN
cord-015021-pol2qm74	7932	17	1:8	1:8	CD
cord-015021-pol2qm74	7932	18	ml	ml	NNS
cord-015021-pol2qm74	7932	19	/	/	SYM
cord-015021-pol2qm74	7932	20	kg	kg	NNP
cord-015021-pol2qm74	7932	21	,	,	,
cord-015021-pol2qm74	7932	22	day	day	NN
cord-015021-pol2qm74	7932	23	2:4	2:4	CD
cord-015021-pol2qm74	7932	24	ml	ml	NN
cord-015021-pol2qm74	7932	25	/	/	SYM
cord-015021-pol2qm74	7932	26	kg	kg	NNP
cord-015021-pol2qm74	7932	27	)	)	-RRB-
cord-015021-pol2qm74	7932	28	.	.	.
cord-015021-pol2qm74	7933	1	Second	second	JJ
cord-015021-pol2qm74	7933	2	study	study	NN
cord-015021-pol2qm74	7933	3	period	period	NN
cord-015021-pol2qm74	7934	1	(	(	-LRB-
cord-015021-pol2qm74	7934	2	n=25	n=25	NNP
cord-015021-pol2qm74	7934	3	)	)	-RRB-
cord-015021-pol2qm74	7934	4	:	:	:
cord-015021-pol2qm74	7935	1	IgGMA	IgGMA	NNP
cord-015021-pol2qm74	7936	1	(	(	-LRB-
cord-015021-pol2qm74	7936	2	Pentaglobin	Pentaglobin	NNP
cord-015021-pol2qm74	7936	3	R	R	NNP
cord-015021-pol2qm74	7936	4	,	,	,
cord-015021-pol2qm74	7936	5	Biotest	Biotest	NNP
cord-015021-pol2qm74	7936	6	,	,	,
cord-015021-pol2qm74	7936	7	Dreieich	Dreieich	NNP
cord-015021-pol2qm74	7936	8	,	,	,
cord-015021-pol2qm74	7936	9	FRG	FRG	NNP
cord-015021-pol2qm74	7936	10	,	,	,
cord-015021-pol2qm74	7936	11	5	5	CD
cord-015021-pol2qm74	7936	12	ml	ml	NN
cord-015021-pol2qm74	7936	13	/	/	SYM
cord-015021-pol2qm74	7936	14	kg	kg	NNS
cord-015021-pol2qm74	7936	15	on	on	IN
cord-015021-pol2qm74	7936	16	days	day	NNS
cord-015021-pol2qm74	7936	17	1	1	CD
cord-015021-pol2qm74	7936	18	to	to	IN
cord-015021-pol2qm74	7936	19	3	3	CD
cord-015021-pol2qm74	7936	20	)	)	-RRB-
cord-015021-pol2qm74	7936	21	.	.	.
cord-015021-pol2qm74	7937	1	Results	result	NNS
cord-015021-pol2qm74	7937	2	:	:	:
cord-015021-pol2qm74	7938	1	Ig	Ig	NNP
cord-015021-pol2qm74	7938	2	pat	pat	NNP
cord-015021-pol2qm74	7938	3	.	.	.
cord-015021-pol2qm74	7939	1	and	and	CC
cord-015021-pol2qm74	7939	2	con	con	NNP
cord-015021-pol2qm74	7939	3	.	.	NNP
cord-015021-pol2qm74	7939	4	were	be	VBD
cord-015021-pol2qm74	7939	5	comparable	comparable	JJ
cord-015021-pol2qm74	7939	6	in	in	IN
cord-015021-pol2qm74	7939	7	demographic	demographic	JJ
cord-015021-pol2qm74	7939	8	data	datum	NNS
cord-015021-pol2qm74	7939	9	,	,	,
cord-015021-pol2qm74	7939	10	operation	operation	NN
cord-015021-pol2qm74	7939	11	characteristics	characteristic	NNS
cord-015021-pol2qm74	7939	12	and	and	CC
cord-015021-pol2qm74	7939	13	baseline	baseline	JJ
cord-015021-pol2qm74	7939	14	disease	disease	NN
cord-015021-pol2qm74	7939	15	severity	severity	NN
cord-015021-pol2qm74	7939	16	LAP	LAP	NNP
cord-015021-pol2qm74	7939	17	and	and	CC
cord-015021-pol2qm74	7939	18	Elebute	Elebute	NNP
cord-015021-pol2qm74	7939	19	sepsis	sepsis	NN
cord-015021-pol2qm74	7939	20	scores	score	NNS
cord-015021-pol2qm74	7939	21	)	)	-RRB-
cord-015021-pol2qm74	7939	22	.	.	.
cord-015021-pol2qm74	7940	1	In	in	IN
cord-015021-pol2qm74	7940	2	contrast	contrast	NN
cord-015021-pol2qm74	7940	3	to	to	IN
cord-015021-pol2qm74	7940	4	con	con	NNP
cord-015021-pol2qm74	7940	5	.	.	.
cord-015021-pol2qm74	7941	1	(	(	-LRB-
cord-015021-pol2qm74	7941	2	risk	risk	NN
cord-015021-pol2qm74	7941	3	:	:	:
cord-015021-pol2qm74	7941	4	n=21	n=21	NN
cord-015021-pol2qm74	7941	5	,	,	,
cord-015021-pol2qm74	7941	6	high	high	JJ
cord-015021-pol2qm74	7941	7	-	-	HYPH
cord-015021-pol2qm74	7941	8	risk	risk	NN
cord-015021-pol2qm74	7941	9	:	:	:
cord-015021-pol2qm74	7942	1	n-21	n-21	NNP
cord-015021-pol2qm74	7942	2	)	)	-RRB-
cord-015021-pol2qm74	7942	3	,	,	,
cord-015021-pol2qm74	7942	4	the	the	DT
cord-015021-pol2qm74	7942	5	Ig	Ig	NNP
cord-015021-pol2qm74	7942	6	pat	pat	NNP
cord-015021-pol2qm74	7942	7	.	.	NNP
cord-015021-pol2qm74	7942	8	showed	show	VBD
cord-015021-pol2qm74	7942	9	a	a	DT
cord-015021-pol2qm74	7942	10	marked	mark	VBN
cord-015021-pol2qm74	7942	11	improvement	improvement	NN
cord-015021-pol2qm74	7942	12	in	in	IN
cord-015021-pol2qm74	7942	13	disease	disease	NN
cord-015021-pol2qm74	7942	14	severity	severity	NN
cord-015021-pol2qm74	7942	15	(	(	-LRB-
cord-015021-pol2qm74	7942	16	fall	fall	NN
cord-015021-pol2qm74	7942	17	in	in	IN
cord-015021-pol2qm74	7942	18	AP	AP	NNP
cord-015021-pol2qm74	7942	19	)	)	-RRB-
cord-015021-pol2qm74	7942	20	,	,	,
cord-015021-pol2qm74	7942	21	especially	especially	RB
cord-015021-pol2qm74	7942	22	in	in	IN
cord-015021-pol2qm74	7942	23	the	the	DT
cord-015021-pol2qm74	7942	24	high	high	JJ
cord-015021-pol2qm74	7942	25	-	-	HYPH
cord-015021-pol2qm74	7942	26	risk	risk	NN
cord-015021-pol2qm74	7942	27	group	group	NN
cord-015021-pol2qm74	7942	28	(	(	-LRB-
cord-015021-pol2qm74	7942	29	IgG	IgG	NNP
cord-015021-pol2qm74	7942	30	,	,	,
cord-015021-pol2qm74	7942	31	n=26	n=26	RB
cord-015021-pol2qm74	7942	32	:	:	:
cord-015021-pol2qm74	7942	33	p	p	NN
cord-015021-pol2qm74	7942	34	<	<	XX
cord-015021-pol2qm74	7942	35	O.05	o.05	UH
cord-015021-pol2qm74	7942	36	;	;	.
cord-015021-pol2qm74	7942	37	IgGMA	IgGMA	NNP
cord-015021-pol2qm74	7942	38	,	,	,
cord-015021-pol2qm74	7943	1	n=13	n=13	NNP
cord-015021-pol2qm74	7943	2	:	:	:
cord-015021-pol2qm74	7943	3	p	p	NN
cord-015021-pol2qm74	7943	4	:	:	:
cord-015021-pol2qm74	7943	5	0.08	0.08	CD
cord-015021-pol2qm74	7943	6	)	)	-RRB-
cord-015021-pol2qm74	7943	7	.	.	.
cord-015021-pol2qm74	7944	1	In	in	IN
cord-015021-pol2qm74	7944	2	this	this	DT
cord-015021-pol2qm74	7944	3	group	group	NN
cord-015021-pol2qm74	7944	4	,	,	,
cord-015021-pol2qm74	7944	5	Ig	Ig	NNP
cord-015021-pol2qm74	7944	6	led	lead	VBD
cord-015021-pol2qm74	7944	7	to	to	IN
cord-015021-pol2qm74	7944	8	higher	high	JJR
cord-015021-pol2qm74	7944	9	(	(	-LRB-
cord-015021-pol2qm74	7944	10	p<0.05	p<0.05	CD
cord-015021-pol2qm74	7944	11	)	)	-RRB-
cord-015021-pol2qm74	7944	12	response	response	NN
cord-015021-pol2qm74	7944	13	rates	rate	NNS
cord-015021-pol2qm74	7944	14	,	,	,
cord-015021-pol2qm74	7944	15	defined	define	VBN
cord-015021-pol2qm74	7944	16	as	as	IN
cord-015021-pol2qm74	7944	17	an	an	DT
cord-015021-pol2qm74	7944	18	AP	AP	NNP
cord-015021-pol2qm74	7944	19	score	score	NN
cord-015021-pol2qm74	7944	20	decrease	decrease	VB
cord-015021-pol2qm74	7944	21	->7	->7	NN
cord-015021-pol2qm74	7944	22	within	within	IN
cord-015021-pol2qm74	7944	23	four	four	CD
cord-015021-pol2qm74	7944	24	days	day	NNS
cord-015021-pol2qm74	7944	25	(	(	-LRB-
cord-015021-pol2qm74	7944	26	IgG	igg	NN
cord-015021-pol2qm74	7944	27	:	:	:
cord-015021-pol2qm74	7944	28	54	54	CD
cord-015021-pol2qm74	7944	29	%	%	NN
cord-015021-pol2qm74	7944	30	,	,	,
cord-015021-pol2qm74	7944	31	IgGMA	iggma	NN
cord-015021-pol2qm74	7944	32	:	:	:
cord-015021-pol2qm74	7944	33	62	62	CD
cord-015021-pol2qm74	7944	34	%	%	NN
cord-015021-pol2qm74	7944	35	;	;	:
cord-015021-pol2qm74	7944	36	con	con	NN
cord-015021-pol2qm74	7944	37	.	.	NN
cord-015021-pol2qm74	7944	38	:	:	:
cord-015021-pol2qm74	7944	39	19	19	CD
cord-015021-pol2qm74	7944	40	%	%	NN
cord-015021-pol2qm74	7944	41	)	)	-RRB-
cord-015021-pol2qm74	7944	42	,	,	,
cord-015021-pol2qm74	7944	43	and	and	CC
cord-015021-pol2qm74	7944	44	reduction	reduction	NN
cord-015021-pol2qm74	7944	45	in	in	IN
cord-015021-pol2qm74	7944	46	mortality	mortality	NN
cord-015021-pol2qm74	7944	47	(	(	-LRB-
cord-015021-pol2qm74	7944	48	IgG	IgG	NNP
cord-015021-pol2qm74	7944	49	:	:	:
cord-015021-pol2qm74	7944	50	46	46	CD
cord-015021-pol2qm74	7944	51	%	%	NN
cord-015021-pol2qm74	7944	52	,	,	,
cord-015021-pol2qm74	7944	53	IgGMA	iggma	NN
cord-015021-pol2qm74	7944	54	:	:	:
cord-015021-pol2qm74	7944	55	46	46	CD
cord-015021-pol2qm74	7944	56	%	%	NN
cord-015021-pol2qm74	7944	57	;	;	:
cord-015021-pol2qm74	7944	58	con	con	NN
cord-015021-pol2qm74	7944	59	.	.	NN
cord-015021-pol2qm74	7944	60	:	:	:
cord-015021-pol2qm74	7944	61	76	76	CD
cord-015021-pol2qm74	7944	62	%	%	NN
cord-015021-pol2qm74	7944	63	)	)	-RRB-
cord-015021-pol2qm74	7944	64	,	,	,
cord-015021-pol2qm74	7944	65	statistically	statistically	RB
cord-015021-pol2qm74	7944	66	significant	significant	JJ
cord-015021-pol2qm74	7944	67	(	(	-LRB-
cord-015021-pol2qm74	7944	68	p<0.05	p<0.05	CD
cord-015021-pol2qm74	7944	69	)	)	-RRB-
cord-015021-pol2qm74	7944	70	for	for	IN
cord-015021-pol2qm74	7944	71	Ig	Ig	NNP
cord-015021-pol2qm74	7944	72	treatment	treatment	NN
cord-015021-pol2qm74	7944	73	as	as	IN
cord-015021-pol2qm74	7944	74	a	a	DT
cord-015021-pol2qm74	7944	75	whole	whole	NN
cord-015021-pol2qm74	7944	76	(	(	-LRB-
cord-015021-pol2qm74	7944	77	IgG	igg	NN
cord-015021-pol2qm74	7944	78	and	and	CC
cord-015021-pol2qm74	7944	79	IgGMA	IgGMA	NNP
cord-015021-pol2qm74	7944	80	)	)	-RRB-
cord-015021-pol2qm74	7944	81	.	.	.
cord-015021-pol2qm74	7945	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	7945	2	:	:	:
cord-015021-pol2qm74	7946	1	Given	give	VBN
cord-015021-pol2qm74	7946	2	the	the	DT
cord-015021-pol2qm74	7946	3	good	good	JJ
cord-015021-pol2qm74	7946	4	comparability	comparability	NN
cord-015021-pol2qm74	7946	5	of	of	IN
cord-015021-pol2qm74	7946	6	the	the	DT
cord-015021-pol2qm74	7946	7	study	study	NN
cord-015021-pol2qm74	7946	8	groups	group	NNS
cord-015021-pol2qm74	7946	9	,	,	,
cord-015021-pol2qm74	7946	10	our	-PRON-	PRP$
cord-015021-pol2qm74	7946	11	results	result	NNS
cord-015021-pol2qm74	7946	12	indicate	indicate	VBP
cord-015021-pol2qm74	7946	13	,	,	,
cord-015021-pol2qm74	7946	14	despite	despite	IN
cord-015021-pol2qm74	7946	15	the	the	DT
cord-015021-pol2qm74	7946	16	non	non	JJ
cord-015021-pol2qm74	7946	17	-	-	JJ
cord-015021-pol2qm74	7946	18	randomized	randomized	JJ
cord-015021-pol2qm74	7946	19	design	design	NN
cord-015021-pol2qm74	7946	20	,	,	,
cord-015021-pol2qm74	7946	21	that	that	IN
cord-015021-pol2qm74	7946	22	early	early	JJ
cord-015021-pol2qm74	7946	23	supplemental	supplemental	JJ
cord-015021-pol2qm74	7946	24	Ig	ig	JJ
cord-015021-pol2qm74	7946	25	treatment	treatment	NN
cord-015021-pol2qm74	7946	26	can	can	MD
cord-015021-pol2qm74	7946	27	improve	improve	VB
cord-015021-pol2qm74	7946	28	disease	disease	NN
cord-015021-pol2qm74	7946	29	severity	severity	NN
cord-015021-pol2qm74	7946	30	and	and	CC
cord-015021-pol2qm74	7946	31	may	may	MD
cord-015021-pol2qm74	7946	32	improve	improve	VB
cord-015021-pol2qm74	7946	33	prognosis	prognosis	NN
cord-015021-pol2qm74	7946	34	in	in	IN
cord-015021-pol2qm74	7946	35	prospectively	prospectively	RB
cord-015021-pol2qm74	7946	36	APACHE	APACHE	NNP
cord-015021-pol2qm74	7946	37	II	II	NNP
cord-015021-pol2qm74	7946	38	score	score	NN
cord-015021-pol2qm74	7946	39	-	-	HYPH
cord-015021-pol2qm74	7946	40	identified	identify	VBN
cord-015021-pol2qm74	7946	41	high	high	JJ
cord-015021-pol2qm74	7946	42	-	-	HYPH
cord-015021-pol2qm74	7946	43	risk	risk	NN
cord-015021-pol2qm74	7946	44	patients	patient	NNS
cord-015021-pol2qm74	7946	45	after	after	IN
cord-015021-pol2qm74	7946	46	cardiac	cardiac	JJ
cord-015021-pol2qm74	7946	47	surgery	surgery	NN
cord-015021-pol2qm74	7946	48	.	.	.
cord-015021-pol2qm74	7947	1	Objective	objective	JJ
cord-015021-pol2qm74	7947	2	.	.	.
cord-015021-pol2qm74	7948	1	Elevated	elevated	JJ
cord-015021-pol2qm74	7948	2	plasma	plasma	NN
cord-015021-pol2qm74	7948	3	levels	level	NNS
cord-015021-pol2qm74	7948	4	of	of	IN
cord-015021-pol2qm74	7948	5	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	7948	6	(	(	-LRB-
cord-015021-pol2qm74	7948	7	ET	ET	NNP
cord-015021-pol2qm74	7948	8	)	)	-RRB-
cord-015021-pol2qm74	7948	9	have	have	VBP
cord-015021-pol2qm74	7948	10	been	be	VBN
cord-015021-pol2qm74	7948	11	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7948	12	in	in	IN
cord-015021-pol2qm74	7948	13	both	both	CC
cord-015021-pol2qm74	7948	14	experimental	experimental	JJ
cord-015021-pol2qm74	7948	15	and	and	CC
cord-015021-pol2qm74	7948	16	human	human	JJ
cord-015021-pol2qm74	7948	17	sepsis	sepsis	NN
cord-015021-pol2qm74	7948	18	.	.	.
cord-015021-pol2qm74	7949	1	ET	ET	NNP
cord-015021-pol2qm74	7949	2	has	have	VBZ
cord-015021-pol2qm74	7949	3	been	be	VBN
cord-015021-pol2qm74	7949	4	proposed	propose	VBN
cord-015021-pol2qm74	7949	5	as	as	IN
cord-015021-pol2qm74	7949	6	a	a	DT
cord-015021-pol2qm74	7949	7	sepsis	sepsis	NN
cord-015021-pol2qm74	7949	8	mediator	mediator	NN
cord-015021-pol2qm74	7949	9	leading	lead	VBG
cord-015021-pol2qm74	7949	10	to	to	IN
cord-015021-pol2qm74	7949	11	vasoconstriction	vasoconstriction	NN
cord-015021-pol2qm74	7949	12	with	with	IN
cord-015021-pol2qm74	7949	13	tissue	tissue	NN
cord-015021-pol2qm74	7949	14	hypoperfusion	hypoperfusion	NN
cord-015021-pol2qm74	7949	15	and	and	CC
cord-015021-pol2qm74	7949	16	organ	organ	NN
cord-015021-pol2qm74	7949	17	failure	failure	NN
cord-015021-pol2qm74	7949	18	.	.	.
cord-015021-pol2qm74	7950	1	The	the	DT
cord-015021-pol2qm74	7950	2	aim	aim	NN
cord-015021-pol2qm74	7950	3	of	of	IN
cord-015021-pol2qm74	7950	4	the	the	DT
cord-015021-pol2qm74	7950	5	study	study	NN
cord-015021-pol2qm74	7950	6	was	be	VBD
cord-015021-pol2qm74	7950	7	to	to	TO
cord-015021-pol2qm74	7950	8	determine	determine	VB
cord-015021-pol2qm74	7950	9	the	the	DT
cord-015021-pol2qm74	7950	10	effects	effect	NNS
cord-015021-pol2qm74	7950	11	of	of	IN
cord-015021-pol2qm74	7950	12	sepsis	sepsis	NN
cord-015021-pol2qm74	7950	13	treatment	treatment	NN
cord-015021-pol2qm74	7950	14	with	with	IN
cord-015021-pol2qm74	7950	15	volume	volume	NN
cord-015021-pol2qm74	7950	16	resuscitation	resuscitation	NN
cord-015021-pol2qm74	7950	17	,	,	,
cord-015021-pol2qm74	7950	18	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	7950	19	and	and	CC
cord-015021-pol2qm74	7950	20	the	the	DT
cord-015021-pol2qm74	7950	21	anti	anti	JJ
cord-015021-pol2qm74	7950	22	-	-	JJ
cord-015021-pol2qm74	7950	23	LPS	lps	JJ
cord-015021-pol2qm74	7950	24	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	7950	25	antibody	antibody	NN
cord-015021-pol2qm74	7950	26	ES	ES	NNP
cord-015021-pol2qm74	7950	27	®	®	NNP
cord-015021-pol2qm74	7950	28	on	on	IN
cord-015021-pol2qm74	7950	29	big	big	JJ
cord-015021-pol2qm74	7950	30	ET	et	NN
cord-015021-pol2qm74	7950	31	and	and	CC
cord-015021-pol2qm74	7950	32	active	active	JJ
cord-015021-pol2qm74	7950	33	,	,	,
cord-015021-pol2qm74	7950	34	21	21	CD
cord-015021-pol2qm74	7950	35	aminoacids	aminoacid	NNS
cord-015021-pol2qm74	7950	36	ET	ET	NNP
cord-015021-pol2qm74	7950	37	(	(	-LRB-
cord-015021-pol2qm74	7950	38	ET	ET	NNP
cord-015021-pol2qm74	7950	39	21	21	CD
cord-015021-pol2qm74	7950	40	)	)	-RRB-
cord-015021-pol2qm74	7950	41	in	in	IN
cord-015021-pol2qm74	7950	42	rat	rat	NN
cord-015021-pol2qm74	7950	43	abdominal	abdominal	JJ
cord-015021-pol2qm74	7950	44	sepsis	sepsis	NN
cord-015021-pol2qm74	7950	45	.	.	.
cord-015021-pol2qm74	7951	1	Methods	method	NNS
cord-015021-pol2qm74	7951	2	.	.	.
cord-015021-pol2qm74	7952	1	Lethal	lethal	JJ
cord-015021-pol2qm74	7952	2	peritonitis	peritonitis	NN
cord-015021-pol2qm74	7952	3	was	be	VBD
cord-015021-pol2qm74	7952	4	induced	induce	VBN
cord-015021-pol2qm74	7952	5	with	with	IN
cord-015021-pol2qm74	7952	6	a	a	DT
cord-015021-pol2qm74	7952	7	4	4	CD
cord-015021-pol2qm74	7952	8	mm	mm	NN
cord-015021-pol2qm74	7952	9	coecal	coecal	JJ
cord-015021-pol2qm74	7952	10	perforation	perforation	NN
cord-015021-pol2qm74	7952	11	(	(	-LRB-
cord-015021-pol2qm74	7952	12	CP	CP	NNP
cord-015021-pol2qm74	7952	13	)	)	-RRB-
cord-015021-pol2qm74	7952	14	in	in	IN
cord-015021-pol2qm74	7952	15	male	male	JJ
cord-015021-pol2qm74	7952	16	Wistar	Wistar	NNP
cord-015021-pol2qm74	7952	17	rats	rat	NNS
cord-015021-pol2qm74	7952	18	.	.	.
cord-015021-pol2qm74	7953	1	Plasma	plasma	NN
cord-015021-pol2qm74	7953	2	levels	level	NNS
cord-015021-pol2qm74	7953	3	of	of	IN
cord-015021-pol2qm74	7953	4	big	big	JJ
cord-015021-pol2qm74	7953	5	ET	et	NN
cord-015021-pol2qm74	7953	6	and	and	CC
cord-015021-pol2qm74	7953	7	ET	ET	NNP
cord-015021-pol2qm74	7953	8	21	21	CD
cord-015021-pol2qm74	7953	9	were	be	VBD
cord-015021-pol2qm74	7953	10	determined	determine	VBN
cord-015021-pol2qm74	7953	11	with	with	IN
cord-015021-pol2qm74	7953	12	Amersham	Amersham	NNP
cord-015021-pol2qm74	7953	13	TM	TM	NNP
cord-015021-pol2qm74	7953	14	Endothelin	Endothelin	NNP
cord-015021-pol2qm74	7953	15	RIAs	RIAs	NNP
cord-015021-pol2qm74	7953	16	4	4	CD
cord-015021-pol2qm74	7953	17	,	,	,
cord-015021-pol2qm74	7953	18	8	8	CD
cord-015021-pol2qm74	7953	19	and	and	CC
cord-015021-pol2qm74	7953	20	12	12	CD
cord-015021-pol2qm74	7953	21	h	h	NN
cord-015021-pol2qm74	7953	22	after	after	IN
cord-015021-pol2qm74	7953	23	sepsis	sepsis	NN
cord-015021-pol2qm74	7953	24	induction	induction	NN
cord-015021-pol2qm74	7953	25	.	.	.
cord-015021-pol2qm74	7954	1	Experimental	experimental	JJ
cord-015021-pol2qm74	7954	2	groups	group	NNS
cord-015021-pol2qm74	7954	3	:	:	:
cord-015021-pol2qm74	7955	1	1	1	LS
cord-015021-pol2qm74	7955	2	.	.	.
cord-015021-pol2qm74	7956	1	CP	cp	NN
cord-015021-pol2qm74	7956	2	control	control	NN
cord-015021-pol2qm74	7956	3	,	,	,
cord-015021-pol2qm74	7956	4	2	2	CD
cord-015021-pol2qm74	7956	5	.	.	.
cord-015021-pol2qm74	7957	1	Volume	volume	NN
cord-015021-pol2qm74	7957	2	replacement	replacement	NN
cord-015021-pol2qm74	7957	3	(	(	-LRB-
cord-015021-pol2qm74	7957	4	VR	VR	NNP
cord-015021-pol2qm74	7957	5	)	)	-RRB-
cord-015021-pol2qm74	7957	6	;	;	:
cord-015021-pol2qm74	7957	7	0,9	0,9	CD
cord-015021-pol2qm74	7957	8	%	%	NN
cord-015021-pol2qm74	7957	9	saline	saline	NN
cord-015021-pol2qm74	7957	10	10	10	CD
cord-015021-pol2qm74	7958	1	ml	ml	NNP
cord-015021-pol2qm74	7958	2	/	/	SYM
cord-015021-pol2qm74	7958	3	kg	kg	NNP
cord-015021-pol2qm74	7958	4	/	/	SYM
cord-015021-pol2qm74	7958	5	h	h	NN
cord-015021-pol2qm74	7958	6	continous	continous	JJ
cord-015021-pol2qm74	7958	7	iv	iv	NNP
cord-015021-pol2qm74	7958	8	infusion	infusion	NN
cord-015021-pol2qm74	7958	9	started	start	VBD
cord-015021-pol2qm74	7958	10	after	after	IN
cord-015021-pol2qm74	7958	11	2	2	CD
cord-015021-pol2qm74	7958	12	h	h	NN
cord-015021-pol2qm74	7958	13	,	,	,
cord-015021-pol2qm74	7958	14	3	3	CD
cord-015021-pol2qm74	7958	15	.	.	.
cord-015021-pol2qm74	7959	1	Antibiotic	antibiotic	JJ
cord-015021-pol2qm74	7959	2	;	;	:
cord-015021-pol2qm74	7959	3	imipenem	imipenem	NNP
cord-015021-pol2qm74	7959	4	40	40	CD
cord-015021-pol2qm74	7959	5	mg	mg	NNP
cord-015021-pol2qm74	7959	6	/	/	SYM
cord-015021-pol2qm74	7959	7	kg	kg	NNP
cord-015021-pol2qm74	7959	8	iv	iv	NNP
cord-015021-pol2qm74	7959	9	after	after	IN
cord-015021-pol2qm74	7959	10	2	2	CD
cord-015021-pol2qm74	7959	11	h	h	NN
cord-015021-pol2qm74	7959	12	,	,	,
cord-015021-pol2qm74	7959	13	4	4	CD
cord-015021-pol2qm74	7959	14	.	.	.
cord-015021-pol2qm74	7960	1	E5	E5	NNP
cord-015021-pol2qm74	7960	2	®	®	NNP
cord-015021-pol2qm74	7960	3	;	;	:
cord-015021-pol2qm74	7960	4	10	10	CD
cord-015021-pol2qm74	7960	5	mg	mg	NN
cord-015021-pol2qm74	7960	6	/	/	SYM
cord-015021-pol2qm74	7960	7	kg	kg	NNP
cord-015021-pol2qm74	7961	1	iv	iv	LS
cord-015021-pol2qm74	7961	2	after	after	IN
cord-015021-pol2qm74	7961	3	2	2	CD
cord-015021-pol2qm74	7961	4	h	h	NN
cord-015021-pol2qm74	7961	5	,	,	,
cord-015021-pol2qm74	7961	6	5	5	CD
cord-015021-pol2qm74	7961	7	.	.	.
cord-015021-pol2qm74	7962	1	VR	VR	NNP
cord-015021-pol2qm74	7962	2	+	+	CC
cord-015021-pol2qm74	7962	3	imipenem	imipenem	NNP
cord-015021-pol2qm74	7963	1	+	+	CC
cord-015021-pol2qm74	7964	1	ES	ES	NNP
cord-015021-pol2qm74	7964	2	®	®	NNP
cord-015021-pol2qm74	7964	3	after	after	IN
cord-015021-pol2qm74	7964	4	2	2	CD
cord-015021-pol2qm74	7964	5	h.	h.	NN
cord-015021-pol2qm74	7964	6	Results	result	NNS
cord-015021-pol2qm74	7964	7	.	.	.
cord-015021-pol2qm74	7965	1	High	high	JJ
cord-015021-pol2qm74	7965	2	concentrations	concentration	NNS
cord-015021-pol2qm74	7965	3	of	of	IN
cord-015021-pol2qm74	7965	4	both	both	DT
cord-015021-pol2qm74	7965	5	big	big	JJ
cord-015021-pol2qm74	7965	6	ET	ET	NNP
cord-015021-pol2qm74	7965	7	and	and	CC
cord-015021-pol2qm74	7965	8	ET	ET	NNP
cord-015021-pol2qm74	7965	9	21	21	CD
cord-015021-pol2qm74	7965	10	could	could	MD
cord-015021-pol2qm74	7965	11	be	be	VB
cord-015021-pol2qm74	7965	12	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7965	13	after	after	IN
cord-015021-pol2qm74	7965	14	2	2	CD
cord-015021-pol2qm74	7965	15	h	h	NN
cord-015021-pol2qm74	7965	16	and	and	CC
cord-015021-pol2qm74	7965	17	lasting	last	VBG
cord-015021-pol2qm74	7965	18	for	for	IN
cord-015021-pol2qm74	7965	19	12	12	CD
cord-015021-pol2qm74	7965	20	h	h	NN
cord-015021-pol2qm74	7965	21	after	after	IN
cord-015021-pol2qm74	7965	22	CP	CP	NNP
cord-015021-pol2qm74	7965	23	.	.	.
cord-015021-pol2qm74	7966	1	Neither	neither	DT
cord-015021-pol2qm74	7966	2	volume	volume	NN
cord-015021-pol2qm74	7966	3	replacement	replacement	NN
cord-015021-pol2qm74	7966	4	nor	nor	CC
cord-015021-pol2qm74	7966	5	imipenem	imipenem	NNP
cord-015021-pol2qm74	7966	6	did	do	VBD
cord-015021-pol2qm74	7966	7	influence	influence	VB
cord-015021-pol2qm74	7966	8	the	the	DT
cord-015021-pol2qm74	7966	9	elevated	elevated	JJ
cord-015021-pol2qm74	7966	10	plasma	plasma	NN
cord-015021-pol2qm74	7966	11	ET	et	NN
cord-015021-pol2qm74	7966	12	.	.	.
cord-015021-pol2qm74	7966	13	E5	E5	NNP
cord-015021-pol2qm74	7967	1	®	®	VB
cord-015021-pol2qm74	7967	2	significantly	significantly	RB
cord-015021-pol2qm74	7967	3	reduced	reduce	VBN
cord-015021-pol2qm74	7967	4	ET	ET	NNP
cord-015021-pol2qm74	7967	5	21	21	CD
cord-015021-pol2qm74	7967	6	both	both	DT
cord-015021-pol2qm74	7967	7	4	4	CD
cord-015021-pol2qm74	7967	8	,	,	,
cord-015021-pol2qm74	7967	9	8	8	CD
cord-015021-pol2qm74	7967	10	and	and	CC
cord-015021-pol2qm74	7967	11	12	12	CD
cord-015021-pol2qm74	7967	12	h	h	NN
cord-015021-pol2qm74	7967	13	after	after	IN
cord-015021-pol2qm74	7967	14	sepsis	sepsis	NN
cord-015021-pol2qm74	7967	15	induction	induction	NN
cord-015021-pol2qm74	7967	16	,	,	,
cord-015021-pol2qm74	7967	17	but	but	CC
cord-015021-pol2qm74	7967	18	did	do	VBD
cord-015021-pol2qm74	7967	19	not	not	RB
cord-015021-pol2qm74	7967	20	reduce	reduce	VB
cord-015021-pol2qm74	7967	21	big	big	JJ
cord-015021-pol2qm74	7967	22	ET	et	NN
cord-015021-pol2qm74	7967	23	.	.	.
cord-015021-pol2qm74	7968	1	When	when	WRB
cord-015021-pol2qm74	7968	2	ES	ES	NNP
cord-015021-pol2qm74	7968	3	®	®	NNP
cord-015021-pol2qm74	7968	4	was	be	VBD
cord-015021-pol2qm74	7968	5	combined	combine	VBN
cord-015021-pol2qm74	7968	6	with	with	IN
cord-015021-pol2qm74	7968	7	VR	VR	NNP
cord-015021-pol2qm74	7968	8	and	and	CC
cord-015021-pol2qm74	7968	9	imipenem	imipenem	NNP
cord-015021-pol2qm74	7968	10	,	,	,
cord-015021-pol2qm74	7968	11	reduction	reduction	NN
cord-015021-pol2qm74	7968	12	of	of	IN
cord-015021-pol2qm74	7968	13	ET	ET	NNP
cord-015021-pol2qm74	7968	14	21	21	CD
cord-015021-pol2qm74	7968	15	was	be	VBD
cord-015021-pol2qm74	7968	16	the	the	DT
cord-015021-pol2qm74	7968	17	same	same	JJ
cord-015021-pol2qm74	7968	18	as	as	IN
cord-015021-pol2qm74	7968	19	for	for	IN
cord-015021-pol2qm74	7968	20	E5	e5	NN
cord-015021-pol2qm74	7969	1	®	®	VB
cord-015021-pol2qm74	7969	2	alone	alone	RB
cord-015021-pol2qm74	7969	3	.	.	.
cord-015021-pol2qm74	7970	1	These	these	DT
cord-015021-pol2qm74	7970	2	results	result	NNS
cord-015021-pol2qm74	7970	3	strongly	strongly	RB
cord-015021-pol2qm74	7970	4	suggest	suggest	VBP
cord-015021-pol2qm74	7970	5	that	that	IN
cord-015021-pol2qm74	7970	6	bacteria	bacteria	NNS
cord-015021-pol2qm74	7970	7	and	and	CC
cord-015021-pol2qm74	7970	8	hypovolemia	hypovolemia	NN
cord-015021-pol2qm74	7970	9	per	per	FW
cord-015021-pol2qm74	7970	10	se	se	FW
cord-015021-pol2qm74	7970	11	are	be	VBP
cord-015021-pol2qm74	7970	12	not	not	RB
cord-015021-pol2qm74	7970	13	decisive	decisive	JJ
cord-015021-pol2qm74	7970	14	stimuli	stimulus	NNS
cord-015021-pol2qm74	7970	15	for	for	IN
cord-015021-pol2qm74	7970	16	ET	ET	NNP
cord-015021-pol2qm74	7970	17	production	production	NN
cord-015021-pol2qm74	7970	18	during	during	IN
cord-015021-pol2qm74	7970	19	sepsis	sepsis	NN
cord-015021-pol2qm74	7970	20	.	.	.
cord-015021-pol2qm74	7971	1	E5	E5	NNP
cord-015021-pol2qm74	7972	1	®	®	NNP
cord-015021-pol2qm74	7972	2	reduces	reduce	VBZ
cord-015021-pol2qm74	7972	3	circulating	circulate	VBG
cord-015021-pol2qm74	7972	4	LPS	LPS	NNP
cord-015021-pol2qm74	7972	5	and	and	CC
cord-015021-pol2qm74	7972	6	TNF	TNF	NNP
cord-015021-pol2qm74	7972	7	which	which	WDT
cord-015021-pol2qm74	7972	8	is	be	VBZ
cord-015021-pol2qm74	7972	9	the	the	DT
cord-015021-pol2qm74	7972	10	probable	probable	JJ
cord-015021-pol2qm74	7972	11	mechanism	mechanism	NN
cord-015021-pol2qm74	7972	12	of	of	IN
cord-015021-pol2qm74	7972	13	the	the	DT
cord-015021-pol2qm74	7972	14	suppressed	suppress	VBN
cord-015021-pol2qm74	7972	15	ET	ET	NNP
cord-015021-pol2qm74	7972	16	21	21	CD
cord-015021-pol2qm74	7972	17	synthesis	synthesis	NN
cord-015021-pol2qm74	7972	18	.	.	.
cord-015021-pol2qm74	7973	1	The	the	DT
cord-015021-pol2qm74	7973	2	unaltered	unaltered	JJ
cord-015021-pol2qm74	7973	3	big	big	JJ
cord-015021-pol2qm74	7973	4	ET	ET	NNP
cord-015021-pol2qm74	7973	5	fraction	fraction	NN
cord-015021-pol2qm74	7973	6	after	after	IN
cord-015021-pol2qm74	7973	7	E5	e5	NN
cord-015021-pol2qm74	7974	1	®	®	NNP
cord-015021-pol2qm74	7974	2	treatment	treatment	NN
cord-015021-pol2qm74	7974	3	indicates	indicate	VBZ
cord-015021-pol2qm74	7974	4	conversion	conversion	NN
cord-015021-pol2qm74	7974	5	of	of	IN
cord-015021-pol2qm74	7974	6	big	big	JJ
cord-015021-pol2qm74	7974	7	ET	ET	NNP
cord-015021-pol2qm74	7974	8	to	to	IN
cord-015021-pol2qm74	7974	9	ET	ET	NNP
cord-015021-pol2qm74	7974	10	21	21	CD
cord-015021-pol2qm74	7974	11	as	as	IN
cord-015021-pol2qm74	7974	12	the	the	DT
cord-015021-pol2qm74	7974	13	site	site	NN
cord-015021-pol2qm74	7974	14	of	of	IN
cord-015021-pol2qm74	7974	15	action	action	NN
cord-015021-pol2qm74	7974	16	responsible	responsible	JJ
cord-015021-pol2qm74	7974	17	for	for	IN
cord-015021-pol2qm74	7974	18	reduced	reduce	VBN
cord-015021-pol2qm74	7974	19	ET	ET	NNP
cord-015021-pol2qm74	7974	20	21	21	CD
cord-015021-pol2qm74	7974	21	.	.	.
cord-015021-pol2qm74	7975	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	7975	2	.	.	.
cord-015021-pol2qm74	7976	1	Lethal	lethal	JJ
cord-015021-pol2qm74	7976	2	peritonitis	peritonitis	NN
cord-015021-pol2qm74	7976	3	in	in	IN
cord-015021-pol2qm74	7976	4	the	the	DT
cord-015021-pol2qm74	7976	5	rat	rat	NN
cord-015021-pol2qm74	7976	6	is	be	VBZ
cord-015021-pol2qm74	7976	7	followed	follow	VBN
cord-015021-pol2qm74	7976	8	by	by	IN
cord-015021-pol2qm74	7976	9	elevated	elevated	JJ
cord-015021-pol2qm74	7976	10	plasma	plasma	NN
cord-015021-pol2qm74	7976	11	levels	level	NNS
cord-015021-pol2qm74	7976	12	of	of	IN
cord-015021-pol2qm74	7976	13	big	big	JJ
cord-015021-pol2qm74	7976	14	ET	et	NN
cord-015021-pol2qm74	7976	15	and	and	CC
cord-015021-pol2qm74	7976	16	ET	ET	NNP
cord-015021-pol2qm74	7976	17	21	21	CD
cord-015021-pol2qm74	7976	18	.	.	.
cord-015021-pol2qm74	7977	1	E5	E5	NNP
cord-015021-pol2qm74	7978	1	®	®	.
cord-015021-pol2qm74	7979	1	anti	anti	JJ
cord-015021-pol2qm74	7979	2	-	-	JJ
cord-015021-pol2qm74	7979	3	LPS	lps	JJ
cord-015021-pol2qm74	7979	4	antibody	antibody	NN
cord-015021-pol2qm74	7979	5	significantly	significantly	RB
cord-015021-pol2qm74	7979	6	reduces	reduce	VBZ
cord-015021-pol2qm74	7979	7	plasma	plasma	NN
cord-015021-pol2qm74	7979	8	ET	ET	NNP
cord-015021-pol2qm74	7979	9	21	21	CD
cord-015021-pol2qm74	7979	10	while	while	IN
cord-015021-pol2qm74	7979	11	volume	volume	NN
cord-015021-pol2qm74	7979	12	resuscitation	resuscitation	NN
cord-015021-pol2qm74	7979	13	and	and	CC
cord-015021-pol2qm74	7979	14	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	7979	15	failed	fail	VBD
cord-015021-pol2qm74	7979	16	to	to	TO
cord-015021-pol2qm74	7979	17	do	do	VB
cord-015021-pol2qm74	7979	18	the	the	DT
cord-015021-pol2qm74	7979	19	same	same	JJ
cord-015021-pol2qm74	7979	20	.	.	.
cord-015021-pol2qm74	7980	1	ES	ES	NNP
cord-015021-pol2qm74	7980	2	®	®	NNP
cord-015021-pol2qm74	7980	3	did	do	VBD
cord-015021-pol2qm74	7980	4	not	not	RB
cord-015021-pol2qm74	7980	5	reduce	reduce	VB
cord-015021-pol2qm74	7980	6	plasma	plasma	NN
cord-015021-pol2qm74	7980	7	big	big	JJ
cord-015021-pol2qm74	7980	8	ET	et	NN
cord-015021-pol2qm74	7980	9	.	.	.
cord-015021-pol2qm74	7981	1	PMX	pmx	NN
cord-015021-pol2qm74	7981	2	treatment	treatment	NN
cord-015021-pol2qm74	7981	3	on	on	IN
cord-015021-pol2qm74	7981	4	severe	severe	JJ
cord-015021-pol2qm74	7981	5	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7981	6	with	with	IN
cord-015021-pol2qm74	7981	7	multiple	multiple	JJ
cord-015021-pol2qm74	7981	8	organ	organ	NN
cord-015021-pol2qm74	7981	9	failure	failure	NN
cord-015021-pol2qm74	7981	10	was	be	VBD
cord-015021-pol2qm74	7981	11	safety	safety	NN
cord-015021-pol2qm74	7981	12	and	and	CC
cord-015021-pol2qm74	7981	13	effect	effect	NN
cord-015021-pol2qm74	7981	14	in	in	IN
cord-015021-pol2qm74	7981	15	prognosis	prognosis	NN
cord-015021-pol2qm74	7981	16	,	,	,
cord-015021-pol2qm74	7981	17	and	and	CC
cord-015021-pol2qm74	7981	18	sepsis	sepsis	NN
cord-015021-pol2qm74	7981	19	related	relate	VBN
cord-015021-pol2qm74	7981	20	parameters	parameter	NNS
cord-015021-pol2qm74	7981	21	.	.	.
cord-015021-pol2qm74	7982	1	It	-PRON-	PRP
cord-015021-pol2qm74	7982	2	was	be	VBD
cord-015021-pol2qm74	7982	3	certified	certify	VBN
cord-015021-pol2qm74	7982	4	that	that	DT
cord-015021-pol2qm74	7982	5	reduction	reduction	NN
cord-015021-pol2qm74	7982	6	of	of	IN
cord-015021-pol2qm74	7982	7	plasma	plasma	NN
cord-015021-pol2qm74	7982	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7982	9	was	be	VBD
cord-015021-pol2qm74	7982	10	effective	effective	JJ
cord-015021-pol2qm74	7982	11	in	in	IN
cord-015021-pol2qm74	7982	12	severe	severe	JJ
cord-015021-pol2qm74	7982	13	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	7982	14	.	.	.
cord-015021-pol2qm74	7983	1	A.	A.	NNP
cord-015021-pol2qm74	7983	2	Lechleuthner	Lechleuthner	NNP
cord-015021-pol2qm74	7983	3	,	,	,
cord-015021-pol2qm74	7983	4	S.	S.	NNP
cord-015021-pol2qm74	7983	5	Aymaz	Aymaz	NNP
cord-015021-pol2qm74	7983	6	,	,	,
cord-015021-pol2qm74	7983	7	G.	G.	NNP
cord-015021-pol2qm74	7983	8	Grass	Grass	NNP
cord-015021-pol2qm74	7983	9	,	,	,
cord-015021-pol2qm74	7983	10	C.	C.	NNP
cord-015021-pol2qm74	7983	11	Stosch	Stosch	NNP
cord-015021-pol2qm74	7983	12	,	,	,
cord-015021-pol2qm74	7983	13	S.	S.	NNP
cord-015021-pol2qm74	7983	14	Dimmeler	Dimmeler	NNP
cord-015021-pol2qm74	7983	15	,	,	,
cord-015021-pol2qm74	7983	16	M.	M.	NNP
cord-015021-pol2qm74	7983	17	Nagelschmidt	Nagelschmidt	NNP
cord-015021-pol2qm74	7983	18	,	,	,
cord-015021-pol2qm74	7983	19	E.	E.	NNP
cord-015021-pol2qm74	7983	20	Neugebauer	Neugebauer	NNP
cord-015021-pol2qm74	7983	21	.	.	.
cord-015021-pol2qm74	7984	1	II	II	NNP
cord-015021-pol2qm74	7984	2	.	.	.
cord-015021-pol2qm74	7985	1	Dept	Dept	NNP
cord-015021-pol2qm74	7985	2	.	.	.
cord-015021-pol2qm74	7986	1	Surgery	surgery	NN
cord-015021-pol2qm74	7986	2	,	,	,
cord-015021-pol2qm74	7986	3	University	University	NNP
cord-015021-pol2qm74	7986	4	of	of	IN
cord-015021-pol2qm74	7986	5	Cologne	Cologne	NNP
cord-015021-pol2qm74	7986	6	,	,	,
cord-015021-pol2qm74	7986	7	Germany	Germany	NNP
cord-015021-pol2qm74	7986	8	.	.	.
cord-015021-pol2qm74	7987	1	Introduction	introduction	NN
cord-015021-pol2qm74	7987	2	:	:	:
cord-015021-pol2qm74	7988	1	The	the	DT
cord-015021-pol2qm74	7988	2	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	7988	3	therapy	therapy	NN
cord-015021-pol2qm74	7988	4	of	of	IN
cord-015021-pol2qm74	7988	5	hypodynarnic	hypodynarnic	NNP
cord-015021-pol2qm74	7988	6	shock	shock	NN
cord-015021-pol2qm74	7988	7	states	state	NNS
cord-015021-pol2qm74	7988	8	is	be	VBZ
cord-015021-pol2qm74	7988	9	a	a	DT
cord-015021-pol2qm74	7988	10	challenging	challenging	JJ
cord-015021-pol2qm74	7988	11	problem	problem	NN
cord-015021-pol2qm74	7988	12	.	.	.
cord-015021-pol2qm74	7989	1	In	in	IN
cord-015021-pol2qm74	7989	2	clinical	clinical	JJ
cord-015021-pol2qm74	7989	3	as	as	RB
cord-015021-pol2qm74	7989	4	well	well	RB
cord-015021-pol2qm74	7989	5	as	as	IN
cord-015021-pol2qm74	7989	6	experimental	experimental	JJ
cord-015021-pol2qm74	7989	7	studies	study	NNS
cord-015021-pol2qm74	7989	8	beneficial	beneficial	JJ
cord-015021-pol2qm74	7989	9	functions	function	NNS
cord-015021-pol2qm74	7989	10	of	of	IN
cord-015021-pol2qm74	7989	11	a	a	DT
cord-015021-pol2qm74	7989	12	new	new	JJ
cord-015021-pol2qm74	7989	13	Hg	hg	NN
cord-015021-pol2qm74	7989	14	-	-	HYPH
cord-015021-pol2qm74	7989	15	agonist	agonist	NN
cord-015021-pol2qm74	7989	16	BU	BU	NNP
cord-015021-pol2qm74	7989	17	-	-	HYPH
cord-015021-pol2qm74	7989	18	E-75	E-75	NNP
cord-015021-pol2qm74	7989	19	in	in	IN
cord-015021-pol2qm74	7989	20	congestive	congestive	JJ
cord-015021-pol2qm74	7989	21	heart	heart	NN
cord-015021-pol2qm74	7989	22	failure	failure	NN
cord-015021-pol2qm74	7989	23	has	have	VBZ
cord-015021-pol2qm74	7989	24	been	be	VBN
cord-015021-pol2qm74	7989	25	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	7989	26	03aumann	03aumann	CD
cord-015021-pol2qm74	7989	27	,	,	,
cord-015021-pol2qm74	7989	28	1989	1989	CD
cord-015021-pol2qm74	7989	29	)	)	-RRB-
cord-015021-pol2qm74	7989	30	.	.	.
cord-015021-pol2qm74	7990	1	Therefore	therefore	RB
cord-015021-pol2qm74	7990	2	,	,	,
cord-015021-pol2qm74	7990	3	we	-PRON-	PRP
cord-015021-pol2qm74	7990	4	investigated	investigate	VBD
cord-015021-pol2qm74	7990	5	the	the	DT
cord-015021-pol2qm74	7990	6	effect	effect	NN
cord-015021-pol2qm74	7990	7	of	of	IN
cord-015021-pol2qm74	7990	8	BU	BU	NNP
cord-015021-pol2qm74	7990	9	-	-	HYPH
cord-015021-pol2qm74	7990	10	E-75	E-75	NNP
cord-015021-pol2qm74	7990	11	in	in	IN
cord-015021-pol2qm74	7990	12	hypodynamic	hypodynamic	JJ
cord-015021-pol2qm74	7990	13	shock	shock	NN
cord-015021-pol2qm74	7990	14	in	in	IN
cord-015021-pol2qm74	7990	15	pigs	pig	NNS
cord-015021-pol2qm74	7990	16	.	.	.
cord-015021-pol2qm74	7991	1	Materials	material	NNS
cord-015021-pol2qm74	7991	2	and	and	CC
cord-015021-pol2qm74	7991	3	Methods	method	NNS
cord-015021-pol2qm74	7991	4	:	:	:
cord-015021-pol2qm74	7991	5	Pigs	pig	NNS
cord-015021-pol2qm74	7991	6	(	(	-LRB-
cord-015021-pol2qm74	7991	7	Deutsches	Deutsches	NNP
cord-015021-pol2qm74	7991	8	Hausschwein	Hausschwein	NNP
cord-015021-pol2qm74	7991	9	,	,	,
cord-015021-pol2qm74	7991	10	Pitrain	Pitrain	NNP
cord-015021-pol2qm74	7991	11	,	,	,
cord-015021-pol2qm74	7991	12	[	[	-LRB-
cord-015021-pol2qm74	7991	13	20	20	CD
cord-015021-pol2qm74	7991	14	]	]	-RRB-
cord-015021-pol2qm74	7991	15	[	[	-LRB-
cord-015021-pol2qm74	7991	16	21	21	CD
cord-015021-pol2qm74	7991	17	]	]	-RRB-
cord-015021-pol2qm74	7991	18	[	[	-LRB-
cord-015021-pol2qm74	7991	19	22	22	CD
cord-015021-pol2qm74	7991	20	]	]	-RRB-
cord-015021-pol2qm74	7991	21	[	[	-LRB-
cord-015021-pol2qm74	7991	22	23	23	CD
cord-015021-pol2qm74	7991	23	]	]	-RRB-
cord-015021-pol2qm74	7991	24	[	[	-LRB-
cord-015021-pol2qm74	7991	25	24	24	CD
cord-015021-pol2qm74	7991	26	]	]	-RRB-
cord-015021-pol2qm74	7991	27	[	[	-LRB-
cord-015021-pol2qm74	7991	28	25	25	CD
cord-015021-pol2qm74	7991	29	]	]	-RRB-
cord-015021-pol2qm74	7991	30	were	be	VBD
cord-015021-pol2qm74	7991	31	anesthesized	anesthesize	VBN
cord-015021-pol2qm74	7991	32	with	with	IN
cord-015021-pol2qm74	7991	33	Fentanyl	Fentanyl	NNP
cord-015021-pol2qm74	7991	34	/	/	SYM
cord-015021-pol2qm74	7991	35	Dormicum	Dormicum	NNP
cord-015021-pol2qm74	7991	36	,	,	,
cord-015021-pol2qm74	7991	37	ventilated	ventilate	VBN
cord-015021-pol2qm74	7992	1	(	(	-LRB-
cord-015021-pol2qm74	7992	2	N20	N20	NNP
cord-015021-pol2qm74	7992	3	:	:	:
cord-015021-pol2qm74	7992	4	O	o	NN
cord-015021-pol2qm74	7992	5	2	2	CD
cord-015021-pol2qm74	7992	6	=	=	SYM
cord-015021-pol2qm74	7992	7	2:1	2:1	CD
cord-015021-pol2qm74	7992	8	)	)	-RRB-
cord-015021-pol2qm74	7992	9	and	and	CC
cord-015021-pol2qm74	7992	10	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	7992	11	parameters	parameter	NNS
cord-015021-pol2qm74	7992	12	were	be	VBD
cord-015021-pol2qm74	7992	13	monitored	monitor	VBN
cord-015021-pol2qm74	7992	14	with	with	IN
cord-015021-pol2qm74	7992	15	a	a	DT
cord-015021-pol2qm74	7992	16	complete	complete	JJ
cord-015021-pol2qm74	7992	17	ICU	ICU	NNP
cord-015021-pol2qm74	7992	18	-	-	HYPH
cord-015021-pol2qm74	7992	19	eqnipment	eqnipment	NN
cord-015021-pol2qm74	7992	20	.	.	.
cord-015021-pol2qm74	7993	1	The	the	DT
cord-015021-pol2qm74	7993	2	hypodynamic	hypodynamic	NN
cord-015021-pol2qm74	7993	3	model	model	NN
cord-015021-pol2qm74	7993	4	was	be	VBD
cord-015021-pol2qm74	7993	5	established	establish	VBN
cord-015021-pol2qm74	7993	6	in	in	IN
cord-015021-pol2qm74	7993	7	a	a	DT
cord-015021-pol2qm74	7993	8	pilot	pilot	NN
cord-015021-pol2qm74	7993	9	study	study	NN
cord-015021-pol2qm74	7993	10	(	(	-LRB-
cord-015021-pol2qm74	7993	11	4	4	CD
cord-015021-pol2qm74	7993	12	animals	animal	NNS
cord-015021-pol2qm74	7993	13	)	)	-RRB-
cord-015021-pol2qm74	7993	14	to	to	TO
cord-015021-pol2qm74	7993	15	evaluate	evaluate	VB
cord-015021-pol2qm74	7993	16	the	the	DT
cord-015021-pol2qm74	7993	17	effective	effective	JJ
cord-015021-pol2qm74	7993	18	concentration	concentration	NN
cord-015021-pol2qm74	7993	19	of	of	IN
cord-015021-pol2qm74	7993	20	BUE-75	BUE-75	NNP
cord-015021-pol2qm74	7994	1	in	in	IN
cord-015021-pol2qm74	7994	2	healthy	healthy	JJ
cord-015021-pol2qm74	7994	3	and	and	CC
cord-015021-pol2qm74	7994	4	endotoxin	endotoxin	NN
cord-015021-pol2qm74	7994	5	(	(	-LRB-
cord-015021-pol2qm74	7994	6	LPS)-treated	lps)-treate	VBN
cord-015021-pol2qm74	7994	7	animals	animal	NNS
cord-015021-pol2qm74	7994	8	.	.	.
cord-015021-pol2qm74	7995	1	Endotoxic	endotoxic	JJ
cord-015021-pol2qm74	7995	2	shock	shock	NN
cord-015021-pol2qm74	7995	3	was	be	VBD
cord-015021-pol2qm74	7995	4	induced	induce	VBN
cord-015021-pol2qm74	7995	5	by	by	IN
cord-015021-pol2qm74	7995	6	continous	continous	JJ
cord-015021-pol2qm74	7995	7	infusion	infusion	NN
cord-015021-pol2qm74	7995	8	of	of	IN
cord-015021-pol2qm74	7995	9	10	10	CD
cord-015021-pol2qm74	7996	1	~g	~g	NNP
cord-015021-pol2qm74	7996	2	LPS	LPS	NNP
cord-015021-pol2qm74	7996	3	/	/	SYM
cord-015021-pol2qm74	7996	4	kgKG	kgKG	NNP
cord-015021-pol2qm74	7996	5	/	/	SYM
cord-015021-pol2qm74	7996	6	h	h	NN
cord-015021-pol2qm74	7996	7	(	(	-LRB-
cord-015021-pol2qm74	7996	8	055	055	CD
cord-015021-pol2qm74	7996	9	:	:	:
cord-015021-pol2qm74	7996	10	B5	b5	NN
cord-015021-pol2qm74	7996	11	,	,	,
cord-015021-pol2qm74	7996	12	Fa	Fa	NNP
cord-015021-pol2qm74	7996	13	.	.	.
cord-015021-pol2qm74	7997	1	Difco	Difco	NNP
cord-015021-pol2qm74	7997	2	)	)	-RRB-
cord-015021-pol2qm74	7997	3	.	.	.
cord-015021-pol2qm74	7998	1	The	the	DT
cord-015021-pol2qm74	7998	2	hypodynamic	hypodynamic	NNP
cord-015021-pol2qm74	7998	3	state	state	NN
cord-015021-pol2qm74	7998	4	was	be	VBD
cord-015021-pol2qm74	7998	5	defined	define	VBN
cord-015021-pol2qm74	7998	6	as	as	IN
cord-015021-pol2qm74	7998	7	a	a	DT
cord-015021-pol2qm74	7998	8	decrease	decrease	NN
cord-015021-pol2qm74	7998	9	of	of	IN
cord-015021-pol2qm74	7998	10	cardiac	cardiac	JJ
cord-015021-pol2qm74	7998	11	output	output	NN
cord-015021-pol2qm74	7998	12	by	by	IN
cord-015021-pol2qm74	7998	13	30	30	CD
cord-015021-pol2qm74	7998	14	%	%	NN
cord-015021-pol2qm74	7998	15	of	of	IN
cord-015021-pol2qm74	7998	16	steady	steady	JJ
cord-015021-pol2qm74	7998	17	state	state	NN
cord-015021-pol2qm74	7998	18	levels	level	NNS
cord-015021-pol2qm74	7998	19	.	.	.
cord-015021-pol2qm74	7999	1	A	a	DT
cord-015021-pol2qm74	7999	2	wedge	wedge	NN
cord-015021-pol2qm74	7999	3	pressure	pressure	NN
cord-015021-pol2qm74	7999	4	of	of	IN
cord-015021-pol2qm74	7999	5	10	10	CD
cord-015021-pol2qm74	7999	6	-	-	SYM
cord-015021-pol2qm74	7999	7	12	12	CD
cord-015021-pol2qm74	7999	8	mmHg	mmHg	NNS
cord-015021-pol2qm74	7999	9	was	be	VBD
cord-015021-pol2qm74	7999	10	kept	keep	VBN
cord-015021-pol2qm74	7999	11	constant	constant	JJ
cord-015021-pol2qm74	7999	12	by	by	IN
cord-015021-pol2qm74	7999	13	volume	volume	NN
cord-015021-pol2qm74	7999	14	resucitation	resucitation	NN
cord-015021-pol2qm74	7999	15	during	during	IN
cord-015021-pol2qm74	7999	16	the	the	DT
cord-015021-pol2qm74	7999	17	experiment	experiment	NN
cord-015021-pol2qm74	7999	18	.	.	.
cord-015021-pol2qm74	8000	1	In	in	IN
cord-015021-pol2qm74	8000	2	a	a	DT
cord-015021-pol2qm74	8000	3	subsequent	subsequent	JJ
cord-015021-pol2qm74	8000	4	randomized	randomize	VBN
cord-015021-pol2qm74	8000	5	controlled	control	VBN
cord-015021-pol2qm74	8000	6	trial	trial	NN
cord-015021-pol2qm74	8000	7	(	(	-LRB-
cord-015021-pol2qm74	8000	8	RTC	RTC	NNP
cord-015021-pol2qm74	8000	9	)	)	-RRB-
cord-015021-pol2qm74	8000	10	3	3	CD
cord-015021-pol2qm74	8000	11	groups	group	NNS
cord-015021-pol2qm74	8000	12	with	with	IN
cord-015021-pol2qm74	8000	13	6	6	CD
cord-015021-pol2qm74	8000	14	animals	animal	NNS
cord-015021-pol2qm74	8000	15	per	per	IN
cord-015021-pol2qm74	8000	16	group	group	NN
cord-015021-pol2qm74	8000	17	were	be	VBD
cord-015021-pol2qm74	8000	18	studied	study	VBN
cord-015021-pol2qm74	8000	19	.	.	.
cord-015021-pol2qm74	8001	1	The	the	DT
cord-015021-pol2qm74	8001	2	groups	group	NNS
cord-015021-pol2qm74	8001	3	were	be	VBD
cord-015021-pol2qm74	8001	4	treated	treat	VBN
cord-015021-pol2qm74	8001	5	as	as	IN
cord-015021-pol2qm74	8001	6	follows	follow	VBZ
cord-015021-pol2qm74	8001	7	:	:	:
cord-015021-pol2qm74	8001	8	group	group	NN
cord-015021-pol2qm74	8001	9	I	I	NNP
cord-015021-pol2qm74	8001	10	,	,	,
cord-015021-pol2qm74	8001	11	LPS	LPS	NNP
cord-015021-pol2qm74	8001	12	and	and	CC
cord-015021-pol2qm74	8001	13	0,9	0,9	CD
cord-015021-pol2qm74	8001	14	%	%	NN
cord-015021-pol2qm74	8001	15	NaC1	nac1	NN
cord-015021-pol2qm74	8001	16	;	;	:
cord-015021-pol2qm74	8001	17	group	group	NN
cord-015021-pol2qm74	8001	18	II	II	NNP
cord-015021-pol2qm74	8001	19	,	,	,
cord-015021-pol2qm74	8001	20	LPS	LPS	NNP
cord-015021-pol2qm74	8001	21	and	and	CC
cord-015021-pol2qm74	8001	22	BU	BU	NNP
cord-015021-pol2qm74	8001	23	-	-	HYPH
cord-015021-pol2qm74	8001	24	E-75	E-75	NNP
cord-015021-pol2qm74	8001	25	(	(	-LRB-
cord-015021-pol2qm74	8001	26	100	100	CD
cord-015021-pol2qm74	8001	27	#	#	NN
cord-015021-pol2qm74	8001	28	g	g	NN
cord-015021-pol2qm74	8001	29	/	/	SYM
cord-015021-pol2qm74	8001	30	kgKG	kgKG	NNP
cord-015021-pol2qm74	8001	31	/	/	SYM
cord-015021-pol2qm74	8001	32	h	h	NN
cord-015021-pol2qm74	8001	33	)	)	-RRB-
cord-015021-pol2qm74	8001	34	;	;	:
cord-015021-pol2qm74	8001	35	group	group	NN
cord-015021-pol2qm74	8001	36	III	III	NNP
cord-015021-pol2qm74	8001	37	,	,	,
cord-015021-pol2qm74	8001	38	Famotidine	Famotidine	NNP
cord-015021-pol2qm74	8001	39	(	(	-LRB-
cord-015021-pol2qm74	8001	40	H2-blocker	H2-blocker	NNP
cord-015021-pol2qm74	8001	41	)	)	-RRB-
cord-015021-pol2qm74	8001	42	pretreatment	pretreatment	NN
cord-015021-pol2qm74	8001	43	(	(	-LRB-
cord-015021-pol2qm74	8001	44	1	1	CD
cord-015021-pol2qm74	8001	45	mg	mg	NNP
cord-015021-pol2qm74	8001	46	/	/	SYM
cord-015021-pol2qm74	8001	47	kgKG	kgKG	NNP
cord-015021-pol2qm74	8001	48	)	)	-RRB-
cord-015021-pol2qm74	8001	49	,	,	,
cord-015021-pol2qm74	8001	50	LPS	LPS	NNP
cord-015021-pol2qm74	8001	51	and	and	CC
cord-015021-pol2qm74	8001	52	BU	BU	NNP
cord-015021-pol2qm74	8001	53	-	-	HYPH
cord-015021-pol2qm74	8001	54	E-75	E-75	NNP
cord-015021-pol2qm74	8001	55	.	.	.
cord-015021-pol2qm74	8002	1	Results	result	NNS
cord-015021-pol2qm74	8002	2	:	:	:
cord-015021-pol2qm74	8003	1	The	the	DT
cord-015021-pol2qm74	8003	2	pilot	pilot	NN
cord-015021-pol2qm74	8003	3	study	study	NN
cord-015021-pol2qm74	8003	4	in	in	IN
cord-015021-pol2qm74	8003	5	healthy	healthy	JJ
cord-015021-pol2qm74	8003	6	pigs	pig	NNS
cord-015021-pol2qm74	8003	7	revealed	reveal	VBN
cord-015021-pol2qm74	8003	8	,	,	,
cord-015021-pol2qm74	8003	9	that	that	IN
cord-015021-pol2qm74	8003	10	BU	BU	NNP
cord-015021-pol2qm74	8003	11	-	-	HYPH
cord-015021-pol2qm74	8003	12	E-75	E-75	NNP
cord-015021-pol2qm74	8003	13	had	have	VBD
cord-015021-pol2qm74	8003	14	positive	positive	JJ
cord-015021-pol2qm74	8003	15	inotropic	inotropic	JJ
cord-015021-pol2qm74	8003	16	effects	effect	NNS
cord-015021-pol2qm74	8003	17	.	.	.
cord-015021-pol2qm74	8004	1	These	these	DT
cord-015021-pol2qm74	8004	2	effects	effect	NNS
cord-015021-pol2qm74	8004	3	were	be	VBD
cord-015021-pol2qm74	8004	4	inhibited	inhibit	VBN
cord-015021-pol2qm74	8004	5	by	by	IN
cord-015021-pol2qm74	8004	6	the	the	DT
cord-015021-pol2qm74	8004	7	H	H	NNP
cord-015021-pol2qm74	8004	8	2antagonist	2antagonist	CD
cord-015021-pol2qm74	8004	9	Famotidin	Famotidin	NNP
cord-015021-pol2qm74	8004	10	.	.	.
cord-015021-pol2qm74	8005	1	BU	BU	NNP
cord-015021-pol2qm74	8005	2	-	-	HYPH
cord-015021-pol2qm74	8005	3	E-75	E-75	NNP
cord-015021-pol2qm74	8005	4	however	however	RB
cord-015021-pol2qm74	8005	5	had	have	VBD
cord-015021-pol2qm74	8005	6	no	no	DT
cord-015021-pol2qm74	8005	7	beneficial	beneficial	JJ
cord-015021-pol2qm74	8005	8	effects	effect	NNS
cord-015021-pol2qm74	8005	9	in	in	IN
cord-015021-pol2qm74	8005	10	the	the	DT
cord-015021-pol2qm74	8005	11	hypodynamic	hypodynamic	NNP
cord-015021-pol2qm74	8005	12	phase	phase	NN
cord-015021-pol2qm74	8005	13	of	of	IN
cord-015021-pol2qm74	8005	14	endotoxic	endotoxic	JJ
cord-015021-pol2qm74	8005	15	shock	shock	NN
cord-015021-pol2qm74	8005	16	in	in	IN
cord-015021-pol2qm74	8005	17	the	the	DT
cord-015021-pol2qm74	8005	18	RCT	RCT	NNP
cord-015021-pol2qm74	8005	19	.	.	.
cord-015021-pol2qm74	8006	1	Cardiac	Cardiac	NNP
cord-015021-pol2qm74	8006	2	Index	Index	NNP
cord-015021-pol2qm74	8006	3	(	(	-LRB-
cord-015021-pol2qm74	8006	4	CI	CI	NNP
cord-015021-pol2qm74	8006	5	)	)	-RRB-
cord-015021-pol2qm74	8006	6	and	and	CC
cord-015021-pol2qm74	8006	7	the	the	DT
cord-015021-pol2qm74	8006	8	oxygen	oxygen	NN
cord-015021-pol2qm74	8006	9	delivery	delivery	NN
cord-015021-pol2qm74	8006	10	(	(	-LRB-
cord-015021-pol2qm74	8006	11	DO2	DO2	NNP
cord-015021-pol2qm74	8006	12	)	)	-RRB-
cord-015021-pol2qm74	8006	13	were	be	VBD
cord-015021-pol2qm74	8006	14	not	not	RB
cord-015021-pol2qm74	8006	15	significantly	significantly	RB
cord-015021-pol2qm74	8006	16	influenced	influence	VBN
cord-015021-pol2qm74	8006	17	by	by	IN
cord-015021-pol2qm74	8006	18	BU	BU	NNP
cord-015021-pol2qm74	8006	19	-	-	HYPH
cord-015021-pol2qm74	8006	20	E-75	E-75	NNP
cord-015021-pol2qm74	8006	21	application	application	NN
cord-015021-pol2qm74	8006	22	(	(	-LRB-
cord-015021-pol2qm74	8006	23	group	group	NN
cord-015021-pol2qm74	8006	24	I	-PRON-	PRP
cord-015021-pol2qm74	8006	25	versus	versus	IN
cord-015021-pol2qm74	8006	26	group	group	NN
cord-015021-pol2qm74	8006	27	II	II	NNP
cord-015021-pol2qm74	8006	28	)	)	-RRB-
cord-015021-pol2qm74	8006	29	.	.	.
cord-015021-pol2qm74	8007	1	BU	BU	NNP
cord-015021-pol2qm74	8007	2	-	-	HYPH
cord-015021-pol2qm74	8007	3	E-75	E-75	NNP
cord-015021-pol2qm74	8007	4	did	do	VBD
cord-015021-pol2qm74	8007	5	not	not	RB
cord-015021-pol2qm74	8007	6	ameliorate	ameliorate	VB
cord-015021-pol2qm74	8007	7	the	the	DT
cord-015021-pol2qm74	8007	8	negative	negative	JJ
cord-015021-pol2qm74	8007	9	inotropic	inotropic	JJ
cord-015021-pol2qm74	8007	10	effect	effect	NN
cord-015021-pol2qm74	8007	11	measuring	measure	VBG
cord-015021-pol2qm74	8007	12	left	leave	VBN
cord-015021-pol2qm74	8007	13	ventricular	ventricular	JJ
cord-015021-pol2qm74	8007	14	stroke	stroke	NN
cord-015021-pol2qm74	8007	15	work	work	NN
cord-015021-pol2qm74	8007	16	(	(	-LRB-
cord-015021-pol2qm74	8007	17	LVSW	LVSW	NNP
cord-015021-pol2qm74	8007	18	)	)	-RRB-
cord-015021-pol2qm74	8007	19	in	in	IN
cord-015021-pol2qm74	8007	20	hypodynamic	hypodynamic	NNP
cord-015021-pol2qm74	8007	21	shock	shock	NN
cord-015021-pol2qm74	8007	22	phases	phase	NNS
cord-015021-pol2qm74	8007	23	.	.	.
cord-015021-pol2qm74	8008	1	On	on	IN
cord-015021-pol2qm74	8008	2	the	the	DT
cord-015021-pol2qm74	8008	3	contrary	contrary	NN
cord-015021-pol2qm74	8008	4	,	,	,
cord-015021-pol2qm74	8008	5	BU	BU	NNP
cord-015021-pol2qm74	8008	6	-	-	HYPH
cord-015021-pol2qm74	8008	7	E-75	E-75	NNP
cord-015021-pol2qm74	8008	8	led	lead	VBD
cord-015021-pol2qm74	8008	9	to	to	IN
cord-015021-pol2qm74	8008	10	a	a	DT
cord-015021-pol2qm74	8008	11	further	further	JJ
cord-015021-pol2qm74	8008	12	significant	significant	JJ
cord-015021-pol2qm74	8008	13	decrease	decrease	NN
cord-015021-pol2qm74	8008	14	of	of	IN
cord-015021-pol2qm74	8008	15	LVSW	LVSW	NNP
cord-015021-pol2qm74	8008	16	(	(	-LRB-
cord-015021-pol2qm74	8008	17	p	p	NN
cord-015021-pol2qm74	8008	18	<	<	XX
cord-015021-pol2qm74	8008	19	0,05	0,05	NNP
cord-015021-pol2qm74	8008	20	)	)	-RRB-
cord-015021-pol2qm74	8008	21	.	.	.
cord-015021-pol2qm74	8009	1	Famotidin	Famotidin	NNP
cord-015021-pol2qm74	8009	2	pretreatment	pretreatment	NN
cord-015021-pol2qm74	8009	3	did	do	VBD
cord-015021-pol2qm74	8009	4	not	not	RB
cord-015021-pol2qm74	8009	5	affect	affect	VB
cord-015021-pol2qm74	8009	6	the	the	DT
cord-015021-pol2qm74	8009	7	response	response	NN
cord-015021-pol2qm74	8009	8	(	(	-LRB-
cord-015021-pol2qm74	8009	9	group	group	NN
cord-015021-pol2qm74	8009	10	III	III	NNP
cord-015021-pol2qm74	8009	11	versus	versus	IN
cord-015021-pol2qm74	8009	12	group	group	NN
cord-015021-pol2qm74	8009	13	II	II	NNP
cord-015021-pol2qm74	8009	14	)	)	-RRB-
cord-015021-pol2qm74	8009	15	.	.	.
cord-015021-pol2qm74	8010	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	8010	2	:	:	:
cord-015021-pol2qm74	8011	1	In	in	IN
cord-015021-pol2qm74	8011	2	hypodynamic	hypodynamic	NNP
cord-015021-pol2qm74	8011	3	shock	shock	NN
cord-015021-pol2qm74	8011	4	states	state	VBZ
cord-015021-pol2qm74	8011	5	the	the	DT
cord-015021-pol2qm74	8011	6	H2-agonism	h2-agonism	NN
cord-015021-pol2qm74	8011	7	seemed	seem	VBD
cord-015021-pol2qm74	8011	8	to	to	TO
cord-015021-pol2qm74	8011	9	have	have	VB
cord-015021-pol2qm74	8011	10	no	no	DT
cord-015021-pol2qm74	8011	11	beneficial	beneficial	JJ
cord-015021-pol2qm74	8011	12	effect	effect	NN
cord-015021-pol2qm74	8011	13	under	under	IN
cord-015021-pol2qm74	8011	14	these	these	DT
cord-015021-pol2qm74	8011	15	experimental	experimental	JJ
cord-015021-pol2qm74	8011	16	conditions	condition	NNS
cord-015021-pol2qm74	8011	17	.	.	.
cord-015021-pol2qm74	8012	1	Receptor	receptor	NN
cord-015021-pol2qm74	8012	2	down	down	IN
cord-015021-pol2qm74	8012	3	regulation	regulation	NN
cord-015021-pol2qm74	8012	4	or	or	CC
cord-015021-pol2qm74	8012	5	changes	change	NNS
cord-015021-pol2qm74	8012	6	of	of	IN
cord-015021-pol2qm74	8012	7	signal	signal	NN
cord-015021-pol2qm74	8012	8	transduction	transduction	NN
cord-015021-pol2qm74	8012	9	under	under	IN
cord-015021-pol2qm74	8012	10	septic	septic	JJ
cord-015021-pol2qm74	8012	11	conditions	condition	NNS
cord-015021-pol2qm74	8012	12	may	may	MD
cord-015021-pol2qm74	8012	13	be	be	VB
cord-015021-pol2qm74	8012	14	responsible	responsible	JJ
cord-015021-pol2qm74	8012	15	.	.	.
cord-015021-pol2qm74	8013	1	Cellular	cellular	JJ
cord-015021-pol2qm74	8013	2	studies	study	NNS
cord-015021-pol2qm74	8013	3	may	may	MD
cord-015021-pol2qm74	8013	4	help	help	VB
cord-015021-pol2qm74	8013	5	to	to	TO
cord-015021-pol2qm74	8013	6	identify	identify	VB
cord-015021-pol2qm74	8013	7	these	these	DT
cord-015021-pol2qm74	8013	8	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8013	9	.	.	.
cord-015021-pol2qm74	8014	1	Objectives	objective	NNS
cord-015021-pol2qm74	8014	2	.	.	.
cord-015021-pol2qm74	8015	1	Antithrombin	Antithrombin	NNP
cord-015021-pol2qm74	8015	2	III	iii	CD
cord-015021-pol2qm74	8015	3	inactivation	inactivation	NN
cord-015021-pol2qm74	8015	4	of	of	IN
cord-015021-pol2qm74	8015	5	proccagulant	proccagulant	JJ
cord-015021-pol2qm74	8015	6	proteases	protease	NNS
cord-015021-pol2qm74	8015	7	is	be	VBZ
cord-015021-pol2qm74	8015	8	so	so	RB
cord-015021-pol2qm74	8015	9	far	far	RB
cord-015021-pol2qm74	8015	10	the	the	DT
cord-015021-pol2qm74	8015	11	only	only	JJ
cord-015021-pol2qm74	8015	12	inhibitory	inhibitory	JJ
cord-015021-pol2qm74	8015	13	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8015	14	approach	approach	NN
cord-015021-pol2qm74	8015	15	to	to	IN
cord-015021-pol2qm74	8015	16	disseminated	disseminate	VBN
cord-015021-pol2qm74	8015	17	intravascutar	intravascutar	NNP
cord-015021-pol2qm74	8015	18	coagulation	coagulation	NN
cord-015021-pol2qm74	8015	19	(	(	-LRB-
cord-015021-pol2qm74	8015	20	DIC	DIC	NNP
cord-015021-pol2qm74	8015	21	)	)	-RRB-
cord-015021-pol2qm74	8015	22	.	.	.
cord-015021-pol2qm74	8016	1	We	-PRON-	PRP
cord-015021-pol2qm74	8016	2	therefore	therefore	RB
cord-015021-pol2qm74	8016	3	set	set	VBD
cord-015021-pol2qm74	8016	4	out	out	RP
cord-015021-pol2qm74	8016	5	to	to	TO
cord-015021-pol2qm74	8016	6	investigate	investigate	VB
cord-015021-pol2qm74	8016	7	whether	whether	IN
cord-015021-pol2qm74	8016	8	Cll	Cll	NNP
cord-015021-pol2qm74	8016	9	substitution	substitution	NN
cord-015021-pol2qm74	8016	10	reduces	reduce	VBZ
cord-015021-pol2qm74	8016	11	coagulation	coagulation	NN
cord-015021-pol2qm74	8016	12	activation	activation	NN
cord-015021-pol2qm74	8016	13	in	in	IN
cord-015021-pol2qm74	8016	14	an	an	DT
cord-015021-pol2qm74	8016	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8016	16	induced	induce	VBN
cord-015021-pol2qm74	8016	17	rabbit	rabbit	NN
cord-015021-pol2qm74	8016	18	DIC	DIC	NNP
cord-015021-pol2qm74	8016	19	model	model	NN
cord-015021-pol2qm74	8016	20	.	.	.
cord-015021-pol2qm74	8017	1	Materials	material	NNS
cord-015021-pol2qm74	8017	2	and	and	CC
cord-015021-pol2qm74	8017	3	Methods	method	NNS
cord-015021-pol2qm74	8017	4	.	.	.
cord-015021-pol2qm74	8018	1	29	29	CD
cord-015021-pol2qm74	8018	2	male	male	JJ
cord-015021-pol2qm74	8018	3	rabbits	rabbit	NNS
cord-015021-pol2qm74	8018	4	Chbb	Chbb	NNP
cord-015021-pol2qm74	8018	5	:	:	:
cord-015021-pol2qm74	8018	6	HM(SPF	HM(SPF	NNP
cord-015021-pol2qm74	8018	7	)	)	-RRB-
cord-015021-pol2qm74	8018	8	were	be	VBD
cord-015021-pol2qm74	8018	9	randomty	randomty	NN
cord-015021-pol2qm74	8018	10	assigned	assign	VBN
cord-015021-pol2qm74	8018	11	to	to	IN
cord-015021-pol2qm74	8018	12	one	one	CD
cord-015021-pol2qm74	8018	13	of	of	IN
cord-015021-pol2qm74	8018	14	the	the	DT
cord-015021-pol2qm74	8018	15	following	follow	VBG
cord-015021-pol2qm74	8018	16	groups	group	NNS
cord-015021-pol2qm74	8018	17	.	.	.
cord-015021-pol2qm74	8019	1	Group	group	NN
cord-015021-pol2qm74	8019	2	K	K	NNP
cord-015021-pol2qm74	8019	3	:	:	:
cord-015021-pol2qm74	8019	4	NaCI	NaCI	NNP
cord-015021-pol2qm74	8019	5	0.9	0.9	CD
cord-015021-pol2qm74	8019	6	%	%	NN
cord-015021-pol2qm74	8019	7	(	(	-LRB-
cord-015021-pol2qm74	8019	8	control	control	NN
cord-015021-pol2qm74	8019	9	without	without	IN
cord-015021-pol2qm74	8019	10	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8019	11	,	,	,
cord-015021-pol2qm74	8019	12	n=10	n=10	NNP
cord-015021-pol2qm74	8019	13	)	)	-RRB-
cord-015021-pol2qm74	8019	14	.	.	.
cord-015021-pol2qm74	8020	1	Group	group	NN
cord-015021-pol2qm74	8020	2	E	e	NN
cord-015021-pol2qm74	8020	3	:	:	:
cord-015021-pol2qm74	8020	4	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	8020	5	120	120	CD
cord-015021-pol2qm74	8020	6	tJg	tJg	NNS
cord-015021-pol2qm74	8020	7	kg	kg	NNS
cord-015021-pol2qm74	8020	8	"	"	``
cord-015021-pol2qm74	8020	9	1	1	CD
cord-015021-pol2qm74	8020	10	bolus	bolus	NN
cord-015021-pol2qm74	8020	11	i.v	i.v	NNP
cord-015021-pol2qm74	8020	12	.	.	.
cord-015021-pol2qm74	8021	1	+	+	SYM
cord-015021-pol2qm74	8021	2	NaCI	NaCI	NNP
cord-015021-pol2qm74	8021	3	0.9	0.9	CD
cord-015021-pol2qm74	8021	4	%	%	NN
cord-015021-pol2qm74	8021	5	(	(	-LRB-
cord-015021-pol2qm74	8021	6	control	control	NN
cord-015021-pol2qm74	8021	7	with	with	IN
cord-015021-pol2qm74	8021	8	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8021	9	,	,	,
cord-015021-pol2qm74	8021	10	n=10	n=10	NNP
cord-015021-pol2qm74	8021	11	)	)	-RRB-
cord-015021-pol2qm74	8021	12	.	.	.
cord-015021-pol2qm74	8022	1	Group	group	NN
cord-015021-pol2qm74	8022	2	C	C	NNP
cord-015021-pol2qm74	8022	3	:	:	:
cord-015021-pol2qm74	8022	4	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	8022	5	120	120	CD
cord-015021-pol2qm74	8022	6	pg	pg	NN
cord-015021-pol2qm74	8022	7	kg	kg	NNP
cord-015021-pol2qm74	8022	8	-1	-1	NNP
cord-015021-pol2qm74	8022	9	bolus	bolus	NNP
cord-015021-pol2qm74	8022	10	i.v	i.v	NNP
cord-015021-pol2qm74	8022	11	.	.	.
cord-015021-pol2qm74	8023	1	+	+	CC
cord-015021-pol2qm74	8023	2	Cll	Cll	NNP
cord-015021-pol2qm74	8023	3	400	400	CD
cord-015021-pol2qm74	8023	4	U	U	NNP
cord-015021-pol2qm74	8023	5	kg	kg	NN
cord-015021-pol2qm74	8023	6	-1	-1	NN
cord-015021-pol2qm74	8023	7	bolus	bolus	NN
cord-015021-pol2qm74	8023	8	+	+	CC
cord-015021-pol2qm74	8024	1	400	400	CD
cord-015021-pol2qm74	8024	2	U	U	NNP
cord-015021-pol2qm74	8024	3	kg	kg	NNP
cord-015021-pol2qm74	8024	4	"	"	''
cord-015021-pol2qm74	8024	5	1	1	CD
cord-015021-pol2qm74	8024	6	4h	4h	CD
cord-015021-pol2qm74	8024	7	"	"	''
cord-015021-pol2qm74	8024	8	~	~	NFP
cord-015021-pol2qm74	8024	9	i	i	PRP
cord-015021-pol2qm74	8024	10	,	,	,
cord-015021-pol2qm74	8024	11	v	v	NNP
cord-015021-pol2qm74	8024	12	.	.	.
cord-015021-pol2qm74	8025	1	(	(	-LRB-
cord-015021-pol2qm74	8025	2	treatment	treatment	NN
cord-015021-pol2qm74	8025	3	group	group	NN
cord-015021-pol2qm74	8025	4	,	,	,
cord-015021-pol2qm74	8025	5	n=9	n=9	NN
cord-015021-pol2qm74	8025	6	)	)	-RRB-
cord-015021-pol2qm74	8025	7	.	.	.
cord-015021-pol2qm74	8026	1	All	all	DT
cord-015021-pol2qm74	8026	2	animals	animal	NNS
cord-015021-pol2qm74	8026	3	were	be	VBD
cord-015021-pol2qm74	8026	4	anesthetized	anesthetize	VBN
cord-015021-pol2qm74	8026	5	and	and	CC
cord-015021-pol2qm74	8026	6	mechanically	mechanically	RB
cord-015021-pol2qm74	8026	7	ventilated	ventilate	VBN
cord-015021-pol2qm74	8026	8	.	.	.
cord-015021-pol2qm74	8027	1	Blood	blood	NN
cord-015021-pol2qm74	8027	2	samples	sample	NNS
cord-015021-pol2qm74	8027	3	were	be	VBD
cord-015021-pol2qm74	8027	4	drawn	draw	VBN
cord-015021-pol2qm74	8027	5	prior	prior	RB
cord-015021-pol2qm74	8027	6	to	to	IN
cord-015021-pol2qm74	8027	7	endotoxin	endotoxin	NNP
cord-015021-pol2qm74	8027	8	administration	administration	NNP
cord-015021-pol2qm74	8027	9	(	(	-LRB-
cord-015021-pol2qm74	8027	10	M1	M1	NNP
cord-015021-pol2qm74	8027	11	)	)	-RRB-
cord-015021-pol2qm74	8027	12	and	and	CC
cord-015021-pol2qm74	8027	13	after	after	IN
cord-015021-pol2qm74	8027	14	120	120	CD
cord-015021-pol2qm74	8027	15	(	(	-LRB-
cord-015021-pol2qm74	8027	16	M2	M2	NNP
cord-015021-pol2qm74	8027	17	)	)	-RRB-
cord-015021-pol2qm74	8027	18	and	and	CC
cord-015021-pol2qm74	8027	19	240	240	CD
cord-015021-pol2qm74	8027	20	rain	rain	NN
cord-015021-pol2qm74	8027	21	.	.	.
cord-015021-pol2qm74	8028	1	(	(	-LRB-
cord-015021-pol2qm74	8028	2	M3	M3	NNP
cord-015021-pol2qm74	8028	3	)	)	-RRB-
cord-015021-pol2qm74	8028	4	.	.	.
cord-015021-pol2qm74	8029	1	Thereafter	thereafter	RB
cord-015021-pol2qm74	8029	2	,	,	,
cord-015021-pol2qm74	8029	3	lung	lung	NN
cord-015021-pol2qm74	8029	4	and	and	CC
cord-015021-pol2qm74	8029	5	liver	liver	NN
cord-015021-pol2qm74	8029	6	tissue	tissue	NN
cord-015021-pol2qm74	8029	7	samples	sample	NNS
cord-015021-pol2qm74	8029	8	were	be	VBD
cord-015021-pol2qm74	8029	9	taken	take	VBN
cord-015021-pol2qm74	8029	10	intravitatly	intravitatly	RB
cord-015021-pol2qm74	8029	11	in	in	IN
cord-015021-pol2qm74	8029	12	a	a	DT
cord-015021-pol2qm74	8029	13	standardized	standardized	JJ
cord-015021-pol2qm74	8029	14	fashion	fashion	NN
cord-015021-pol2qm74	8029	15	for	for	IN
cord-015021-pol2qm74	8029	16	H&E	H&E	NNP
cord-015021-pol2qm74	8029	17	microscopic	microscopic	JJ
cord-015021-pol2qm74	8029	18	fibrin	fibrin	NN
cord-015021-pol2qm74	8029	19	quantification	quantification	NN
cord-015021-pol2qm74	8029	20	using	use	VBG
cord-015021-pol2qm74	8029	21	a	a	DT
cord-015021-pol2qm74	8029	22	triple	triple	JJ
cord-015021-pol2qm74	8029	23	score	score	NN
cord-015021-pol2qm74	8029	24	(	(	-LRB-
cord-015021-pol2qm74	8029	25	FIBS	FIBS	NNP
cord-015021-pol2qm74	8029	26	)	)	-RRB-
cord-015021-pol2qm74	8029	27	.	.	.
cord-015021-pol2qm74	8030	1	From	from	IN
cord-015021-pol2qm74	8030	2	all	all	DT
cord-015021-pol2qm74	8030	3	blood	blood	NN
cord-015021-pol2qm74	8030	4	samples	sample	NNS
cord-015021-pol2qm74	8030	5	the	the	DT
cord-015021-pol2qm74	8030	6	prothrombin	prothrombin	NN
cord-015021-pol2qm74	8030	7	time	time	NN
cord-015021-pol2qm74	8030	8	(	(	-LRB-
cord-015021-pol2qm74	8030	9	PT	PT	NNP
cord-015021-pol2qm74	8030	10	)	)	-RRB-
cord-015021-pol2qm74	8030	11	,	,	,
cord-015021-pol2qm74	8030	12	activated	activate	VBD
cord-015021-pol2qm74	8030	13	partial	partial	JJ
cord-015021-pol2qm74	8030	14	thromboplastin	thromboplastin	NNP
cord-015021-pol2qm74	8030	15	time	time	NN
cord-015021-pol2qm74	8030	16	(	(	-LRB-
cord-015021-pol2qm74	8030	17	aPTT	aptt	NN
cord-015021-pol2qm74	8030	18	)	)	-RRB-
cord-015021-pol2qm74	8030	19	,	,	,
cord-015021-pol2qm74	8030	20	fibrin	fibrin	NN
cord-015021-pol2qm74	8030	21	monomers	monomer	NNS
cord-015021-pol2qm74	8030	22	(	(	-LRB-
cord-015021-pol2qm74	8030	23	FM	FM	NNP
cord-015021-pol2qm74	8030	24	)	)	-RRB-
cord-015021-pol2qm74	8030	25	,	,	,
cord-015021-pol2qm74	8030	26	and	and	CC
cord-015021-pol2qm74	8030	27	d	d	NNS
cord-015021-pol2qm74	8030	28	-	-	NNS
cord-015021-pol2qm74	8030	29	dimers	dimer	NNS
cord-015021-pol2qm74	8030	30	(	(	-LRB-
cord-015021-pol2qm74	8030	31	DD	DD	NNP
cord-015021-pol2qm74	8030	32	)	)	-RRB-
cord-015021-pol2qm74	8030	33	were	be	VBD
cord-015021-pol2qm74	8030	34	measured	measure	VBN
cord-015021-pol2qm74	8030	35	.	.	.
cord-015021-pol2qm74	8031	1	For	for	IN
cord-015021-pol2qm74	8031	2	statistical	statistical	JJ
cord-015021-pol2qm74	8031	3	significance	significance	NN
cord-015021-pol2qm74	8031	4	of	of	IN
cord-015021-pol2qm74	8031	5	differences	difference	NNS
cord-015021-pol2qm74	8031	6	between	between	IN
cord-015021-pol2qm74	8031	7	the	the	DT
cord-015021-pol2qm74	8031	8	groups	group	NNS
cord-015021-pol2qm74	8031	9	ANOVAs	anova	NNS
cord-015021-pol2qm74	8031	10	and	and	CC
cord-015021-pol2qm74	8031	11	the	the	DT
cord-015021-pol2qm74	8031	12	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	8031	13	test	test	NN
cord-015021-pol2qm74	8031	14	(	(	-LRB-
cord-015021-pol2qm74	8031	15	FIBS	FIBS	NNP
cord-015021-pol2qm74	8031	16	)	)	-RRB-
cord-015021-pol2qm74	8031	17	were	be	VBD
cord-015021-pol2qm74	8031	18	performed	perform	VBN
cord-015021-pol2qm74	8031	19	.	.	.
cord-015021-pol2qm74	8032	1	Results	result	NNS
cord-015021-pol2qm74	8032	2	.	.	.
cord-015021-pol2qm74	8033	1	FIBS	fib	NNS
cord-015021-pol2qm74	8033	2	for	for	IN
cord-015021-pol2qm74	8033	3	lung	lung	NN
cord-015021-pol2qm74	8033	4	/	/	SYM
cord-015021-pol2qm74	8033	5	liver	liver	NN
cord-015021-pol2qm74	8033	6	were	be	VBD
cord-015021-pol2qm74	8033	7	significantly	significantly	RB
cord-015021-pol2qm74	8033	8	different	different	JJ
cord-015021-pol2qm74	8033	9	(	(	-LRB-
cord-015021-pol2qm74	8033	10	p<0.05	p<0.05	JJ
cord-015021-pol2qm74	8033	11	)	)	-RRB-
cord-015021-pol2qm74	8033	12	between	between	IN
cord-015021-pol2qm74	8033	13	group	group	NN
cord-015021-pol2qm74	8033	14	E	E	NNP
cord-015021-pol2qm74	8033	15	(	(	-LRB-
cord-015021-pol2qm74	8033	16	lung	lung	NNP
cord-015021-pol2qm74	8033	17	180	180	CD
cord-015021-pol2qm74	8033	18	,	,	,
cord-015021-pol2qm74	8033	19	liver	liver	NN
cord-015021-pol2qm74	8033	20	159	159	CD
cord-015021-pol2qm74	8033	21	)	)	-RRB-
cord-015021-pol2qm74	8033	22	and	and	CC
cord-015021-pol2qm74	8033	23	C	C	NNP
cord-015021-pol2qm74	8033	24	(	(	-LRB-
cord-015021-pol2qm74	8033	25	lung	lung	NNP
cord-015021-pol2qm74	8033	26	89	89	CD
cord-015021-pol2qm74	8033	27	,	,	,
cord-015021-pol2qm74	8033	28	liver	liver	NN
cord-015021-pol2qm74	8033	29	0	0	NFP
cord-015021-pol2qm74	8033	30	)	)	-RRB-
cord-015021-pol2qm74	8033	31	(	(	-LRB-
cord-015021-pol2qm74	8033	32	Group	Group	NNP
cord-015021-pol2qm74	8033	33	K	K	NNP
cord-015021-pol2qm74	8033	34	:	:	:
cord-015021-pol2qm74	8033	35	lung	lung	NN
cord-015021-pol2qm74	8033	36	11	11	CD
cord-015021-pol2qm74	8033	37	,	,	,
cord-015021-pol2qm74	8033	38	liver	liver	NN
cord-015021-pol2qm74	8033	39	0	0	CD
cord-015021-pol2qm74	8033	40	)	)	-RRB-
cord-015021-pol2qm74	8033	41	.	.	.
cord-015021-pol2qm74	8033	42	,	,	,
cord-015021-pol2qm74	8033	43	a	a	DT
cord-015021-pol2qm74	8033	44	synthetic	synthetic	JJ
cord-015021-pol2qm74	8033	45	serine	serine	NN
cord-015021-pol2qm74	8033	46	proteinase	proteinase	NN
cord-015021-pol2qm74	8033	47	inhibitor	inhibitor	NN
cord-015021-pol2qm74	8033	48	,	,	,
cord-015021-pol2qm74	8033	49	has	have	VBZ
cord-015021-pol2qm74	8033	50	an	an	DT
cord-015021-pol2qm74	8033	51	anticoagulant	anticoagulant	JJ
cord-015021-pol2qm74	8033	52	activity	activity	NN
cord-015021-pol2qm74	8033	53	in	in	IN
cord-015021-pol2qm74	8033	54	the	the	DT
cord-015021-pol2qm74	8033	55	absence	absence	NN
cord-015021-pol2qm74	8033	56	of	of	IN
cord-015021-pol2qm74	8033	57	"	"	``
cord-015021-pol2qm74	8033	58	antithrobim	antithrobim	NNP
cord-015021-pol2qm74	8033	59	III	III	NNP
cord-015021-pol2qm74	8033	60	.	.	.
cord-015021-pol2qm74	8034	1	Gabexate	Gabexate	NNP
cord-015021-pol2qm74	8034	2	has	have	VBZ
cord-015021-pol2qm74	8034	3	been	be	VBN
cord-015021-pol2qm74	8034	4	reported	report	VBN
cord-015021-pol2qm74	8034	5	to	to	TO
cord-015021-pol2qm74	8034	6	be	be	VB
cord-015021-pol2qm74	8034	7	useful	useful	JJ
cord-015021-pol2qm74	8034	8	in	in	IN
cord-015021-pol2qm74	8034	9	the	the	DT
cord-015021-pol2qm74	8034	10	treatment	treatment	NN
cord-015021-pol2qm74	8034	11	of	of	IN
cord-015021-pol2qm74	8034	12	disseminated	disseminate	VBN
cord-015021-pol2qm74	8034	13	intravascular	intravascular	JJ
cord-015021-pol2qm74	8034	14	coaguiation	coaguiation	NN
cord-015021-pol2qm74	8034	15	due	due	IN
cord-015021-pol2qm74	8034	16	to	to	IN
cord-015021-pol2qm74	8034	17	neoplastic	neoplastic	JJ
cord-015021-pol2qm74	8034	18	diseases	disease	NNS
cord-015021-pol2qm74	8034	19	.	.	.
cord-015021-pol2qm74	8035	1	In	in	IN
cord-015021-pol2qm74	8035	2	this	this	DT
cord-015021-pol2qm74	8035	3	study	study	NN
cord-015021-pol2qm74	8035	4	,	,	,
cord-015021-pol2qm74	8035	5	we	-PRON-	PRP
cord-015021-pol2qm74	8035	6	investigated	investigate	VBD
cord-015021-pol2qm74	8035	7	gabexate	gabexate	NNP
cord-015021-pol2qm74	8035	8	therapy	therapy	NN
cord-015021-pol2qm74	8035	9	for	for	IN
cord-015021-pol2qm74	8035	10	the	the	DT
cord-015021-pol2qm74	8035	11	treatment	treatment	NN
cord-015021-pol2qm74	8035	12	of	of	IN
cord-015021-pol2qm74	8035	13	DIC	DIC	NNP
cord-015021-pol2qm74	8035	14	due	due	IN
cord-015021-pol2qm74	8035	15	to	to	IN
cord-015021-pol2qm74	8035	16	sepsis	sepsis	NN
cord-015021-pol2qm74	8035	17	in	in	IN
cord-015021-pol2qm74	8035	18	the	the	DT
cord-015021-pol2qm74	8035	19	postoperative	postoperative	JJ
cord-015021-pol2qm74	8035	20	critical	critical	JJ
cord-015021-pol2qm74	8035	21	patients	patient	NNS
cord-015021-pol2qm74	8035	22	.	.	.
cord-015021-pol2qm74	8036	1	MATERIALS	materials	NN
cord-015021-pol2qm74	8036	2	AND	and	CC
cord-015021-pol2qm74	8036	3	METHODS	method	NNS
cord-015021-pol2qm74	8036	4	:	:	:
cord-015021-pol2qm74	8037	1	From	from	IN
cord-015021-pol2qm74	8037	2	July	July	NNP
cord-015021-pol2qm74	8037	3	1992	1992	CD
cord-015021-pol2qm74	8037	4	to	to	IN
cord-015021-pol2qm74	8037	5	June	June	NNP
cord-015021-pol2qm74	8037	6	1993	1993	CD
cord-015021-pol2qm74	8037	7	,	,	,
cord-015021-pol2qm74	8037	8	15	15	CD
cord-015021-pol2qm74	8037	9	patients	patient	NNS
cord-015021-pol2qm74	8037	10	in	in	IN
cord-015021-pol2qm74	8037	11	the	the	DT
cord-015021-pol2qm74	8037	12	surgical	surgical	JJ
cord-015021-pol2qm74	8037	13	intensive	intensive	JJ
cord-015021-pol2qm74	8037	14	care	care	NN
cord-015021-pol2qm74	8037	15	unit	unit	NN
cord-015021-pol2qm74	8037	16	met	meet	VBD
cord-015021-pol2qm74	8037	17	the	the	DT
cord-015021-pol2qm74	8037	18	criteria	criterion	NNS
cord-015021-pol2qm74	8037	19	of	of	IN
cord-015021-pol2qm74	8037	20	DIC	DIC	NNP
cord-015021-pol2qm74	8037	21	or	or	CC
cord-015021-pol2qm74	8037	22	pre	pre	JJ
cord-015021-pol2qm74	8037	23	-	-	JJ
cord-015021-pol2qm74	8037	24	DIC	dic	JJ
cord-015021-pol2qm74	8037	25	.	.	.
cord-015021-pol2qm74	8038	1	Eleven	eleven	CD
cord-015021-pol2qm74	8038	2	were	be	VBD
cord-015021-pol2qm74	8038	3	male	male	JJ
cord-015021-pol2qm74	8038	4	and	and	CC
cord-015021-pol2qm74	8038	5	four	four	CD
cord-015021-pol2qm74	8038	6	were	be	VBD
cord-015021-pol2qm74	8038	7	female	female	JJ
cord-015021-pol2qm74	8038	8	with	with	IN
cord-015021-pol2qm74	8038	9	the	the	DT
cord-015021-pol2qm74	8038	10	mean	mean	JJ
cord-015021-pol2qm74	8038	11	age	age	NN
cord-015021-pol2qm74	8038	12	of	of	IN
cord-015021-pol2qm74	8038	13	66.7	66.7	CD
cord-015021-pol2qm74	8038	14	years	year	NNS
cord-015021-pol2qm74	8038	15	.	.	.
cord-015021-pol2qm74	8039	1	All	all	PDT
cord-015021-pol2qm74	8039	2	these	these	DT
cord-015021-pol2qm74	8039	3	patients	patient	NNS
cord-015021-pol2qm74	8039	4	suffered	suffer	VBD
cord-015021-pol2qm74	8039	5	from	from	IN
cord-015021-pol2qm74	8039	6	some	some	DT
cord-015021-pol2qm74	8039	7	complication	complication	NN
cord-015021-pol2qm74	8039	8	of	of	IN
cord-015021-pol2qm74	8039	9	operations	operation	NNS
cord-015021-pol2qm74	8039	10	which	which	WDT
cord-015021-pol2qm74	8039	11	led	lead	VBD
cord-015021-pol2qm74	8039	12	to	to	IN
cord-015021-pol2qm74	8039	13	the	the	DT
cord-015021-pol2qm74	8039	14	development	development	NN
cord-015021-pol2qm74	8039	15	of	of	IN
cord-015021-pol2qm74	8039	16	sepsis	sepsis	NN
cord-015021-pol2qm74	8039	17	.	.	.
cord-015021-pol2qm74	8040	1	FOY	FOY	NNP
cord-015021-pol2qm74	8040	2	was	be	VBD
cord-015021-pol2qm74	8040	3	administered	administer	VBN
cord-015021-pol2qm74	8040	4	at	at	IN
cord-015021-pol2qm74	8040	5	the	the	DT
cord-015021-pol2qm74	8040	6	rate	rate	NN
cord-015021-pol2qm74	8040	7	of	of	IN
cord-015021-pol2qm74	8041	1	2mg	2mg	NNP
cord-015021-pol2qm74	8041	2	/	/	SYM
cord-015021-pol2qm74	8041	3	kg	kg	NN
cord-015021-pol2qm74	8041	4	/	/	SYM
cord-015021-pol2qm74	8041	5	hr	hr	NN
cord-015021-pol2qm74	8041	6	untiI	untii	NN
cord-015021-pol2qm74	8042	1	the	the	DT
cord-015021-pol2qm74	8042	2	coagulation	coagulation	NN
cord-015021-pol2qm74	8042	3	profile	profile	NN
cord-015021-pol2qm74	8042	4	retumed	retume	VBN
cord-015021-pol2qm74	8042	5	to	to	IN
cord-015021-pol2qm74	8042	6	normal	normal	JJ
cord-015021-pol2qm74	8042	7	or	or	CC
cord-015021-pol2qm74	8042	8	the	the	DT
cord-015021-pol2qm74	8042	9	patient	patient	NN
cord-015021-pol2qm74	8042	10	died	die	VBD
cord-015021-pol2qm74	8042	11	.	.	.
cord-015021-pol2qm74	8043	1	The	the	DT
cord-015021-pol2qm74	8043	2	coagulation	coagulation	NN
cord-015021-pol2qm74	8043	3	parameters	parameter	NNS
cord-015021-pol2qm74	8043	4	were	be	VBD
cord-015021-pol2qm74	8043	5	monitored	monitor	VBN
cord-015021-pol2qm74	8043	6	before	before	RB
cord-015021-pol2qm74	8043	7	and	and	CC
cord-015021-pol2qm74	8043	8	on	on	IN
cord-015021-pol2qm74	8043	9	the	the	DT
cord-015021-pol2qm74	8043	10	1st	1st	NN
cord-015021-pol2qm74	8043	11	,	,	,
cord-015021-pol2qm74	8043	12	3rd	3rd	JJ
cord-015021-pol2qm74	8043	13	,	,	,
cord-015021-pol2qm74	8043	14	5th	5th	JJ
cord-015021-pol2qm74	8043	15	and	and	CC
cord-015021-pol2qm74	8043	16	7th	7th	JJ
cord-015021-pol2qm74	8043	17	day	day	NN
cord-015021-pol2qm74	8043	18	.	.	.
cord-015021-pol2qm74	8044	1	RESULTS	result	NNS
cord-015021-pol2qm74	8044	2	:	:	:
cord-015021-pol2qm74	8045	1	Fourteen	fourteen	CD
cord-015021-pol2qm74	8045	2	of	of	IN
cord-015021-pol2qm74	8045	3	these	these	DT
cord-015021-pol2qm74	8045	4	fifteen	fifteen	CD
cord-015021-pol2qm74	8045	5	patients	patient	NNS
cord-015021-pol2qm74	8045	6	died	die	VBD
cord-015021-pol2qm74	8045	7	despite	despite	IN
cord-015021-pol2qm74	8045	8	transient	transient	JJ
cord-015021-pol2qm74	8045	9	improvement	improvement	NN
cord-015021-pol2qm74	8045	10	of	of	IN
cord-015021-pol2qm74	8045	11	the	the	DT
cord-015021-pol2qm74	8045	12	coagulation	coagulation	NN
cord-015021-pol2qm74	8045	13	parameters	parameter	NNS
cord-015021-pol2qm74	8045	14	in	in	IN
cord-015021-pol2qm74	8045	15	five	five	CD
cord-015021-pol2qm74	8045	16	patients	patient	NNS
cord-015021-pol2qm74	8045	17	.	.	.
cord-015021-pol2qm74	8046	1	These	these	DT
cord-015021-pol2qm74	8046	2	patients	patient	NNS
cord-015021-pol2qm74	8046	3	suffered	suffer	VBD
cord-015021-pol2qm74	8046	4	from	from	IN
cord-015021-pol2qm74	8046	5	sepsis	sepsis	NN
cord-015021-pol2qm74	8046	6	resulting	result	VBG
cord-015021-pol2qm74	8046	7	from	from	IN
cord-015021-pol2qm74	8046	8	surgical	surgical	JJ
cord-015021-pol2qm74	8046	9	complications	complication	NNS
cord-015021-pol2qm74	8046	10	which	which	WDT
cord-015021-pol2qm74	8046	11	could	could	MD
cord-015021-pol2qm74	8046	12	not	not	RB
cord-015021-pol2qm74	8046	13	be	be	VB
cord-015021-pol2qm74	8046	14	well	well	RB
cord-015021-pol2qm74	8046	15	controlled	control	VBN
cord-015021-pol2qm74	8046	16	.	.	.
cord-015021-pol2qm74	8047	1	The	the	DT
cord-015021-pol2qm74	8047	2	only	only	JJ
cord-015021-pol2qm74	8047	3	survival	survival	NN
cord-015021-pol2qm74	8047	4	was	be	VBD
cord-015021-pol2qm74	8047	5	a	a	DT
cord-015021-pol2qm74	8047	6	case	case	NN
cord-015021-pol2qm74	8047	7	of	of	IN
cord-015021-pol2qm74	8047	8	recurrent	recurrent	JJ
cord-015021-pol2qm74	8047	9	intrahepatic	intrahepatic	JJ
cord-015021-pol2qm74	8047	10	duct	duct	NN
cord-015021-pol2qm74	8047	11	stone	stone	NN
cord-015021-pol2qm74	8047	12	with	with	IN
cord-015021-pol2qm74	8047	13	biliary	biliary	JJ
cord-015021-pol2qm74	8047	14	tract	tract	NN
cord-015021-pol2qm74	8047	15	infection	infection	NN
cord-015021-pol2qm74	8047	16	complicated	complicate	VBN
cord-015021-pol2qm74	8047	17	with	with	IN
cord-015021-pol2qm74	8047	18	sepsis	sepsis	NN
cord-015021-pol2qm74	8047	19	and	and	CC
cord-015021-pol2qm74	8047	20	DIC	DIC	NNP
cord-015021-pol2qm74	8047	21	.	.	.
cord-015021-pol2qm74	8048	1	After	after	IN
cord-015021-pol2qm74	8048	2	choledocholithotomy	choledocholithotomy	NN
cord-015021-pol2qm74	8048	3	and	and	CC
cord-015021-pol2qm74	8048	4	the	the	DT
cord-015021-pol2qm74	8048	5	use	use	NN
cord-015021-pol2qm74	8048	6	of	of	IN
cord-015021-pol2qm74	8048	7	FOY	FOY	NNP
cord-015021-pol2qm74	8048	8	,	,	,
cord-015021-pol2qm74	8048	9	the	the	DT
cord-015021-pol2qm74	8048	10	patient	patient	NN
cord-015021-pol2qm74	8048	11	recovered	recover	VBD
cord-015021-pol2qm74	8048	12	gradually	gradually	RB
cord-015021-pol2qm74	8048	13	.	.	.
cord-015021-pol2qm74	8049	1	CONCLUSION	conclusion	NN
cord-015021-pol2qm74	8049	2	:	:	:
cord-015021-pol2qm74	8050	1	DIC	DIC	NNP
cord-015021-pol2qm74	8050	2	is	be	VBZ
cord-015021-pol2qm74	8050	3	a	a	DT
cord-015021-pol2qm74	8050	4	late	late	JJ
cord-015021-pol2qm74	8050	5	manifestation	manifestation	NN
cord-015021-pol2qm74	8050	6	of	of	IN
cord-015021-pol2qm74	8050	7	sepsis	sepsis	NN
cord-015021-pol2qm74	8050	8	in	in	IN
cord-015021-pol2qm74	8050	9	the	the	DT
cord-015021-pol2qm74	8050	10	critical	critical	JJ
cord-015021-pol2qm74	8050	11	surgical	surgical	JJ
cord-015021-pol2qm74	8050	12	patients	patient	NNS
cord-015021-pol2qm74	8050	13	.	.	.
cord-015021-pol2qm74	8051	1	The	the	DT
cord-015021-pol2qm74	8051	2	most	most	RBS
cord-015021-pol2qm74	8051	3	important	important	JJ
cord-015021-pol2qm74	8051	4	thing	thing	NN
cord-015021-pol2qm74	8051	5	is	be	VBZ
cord-015021-pol2qm74	8051	6	to	to	TO
cord-015021-pol2qm74	8051	7	eradicate	eradicate	VB
cord-015021-pol2qm74	8051	8	the	the	DT
cord-015021-pol2qm74	8051	9	cause	cause	NN
cord-015021-pol2qm74	8051	10	of	of	IN
cord-015021-pol2qm74	8051	11	sepsis	sepsis	NN
cord-015021-pol2qm74	8051	12	.	.	.
cord-015021-pol2qm74	8052	1	If	if	IN
cord-015021-pol2qm74	8052	2	the	the	DT
cord-015021-pol2qm74	8052	3	underlying	underlie	VBG
cord-015021-pol2qm74	8052	4	septic	septic	JJ
cord-015021-pol2qm74	8052	5	focus	focus	NN
cord-015021-pol2qm74	8052	6	can	can	MD
cord-015021-pol2qm74	8052	7	not	not	RB
cord-015021-pol2qm74	8052	8	be	be	VB
cord-015021-pol2qm74	8052	9	controlled	control	VBN
cord-015021-pol2qm74	8052	10	,	,	,
cord-015021-pol2qm74	8052	11	DIC	DIC	NNP
cord-015021-pol2qm74	8052	12	will	will	MD
cord-015021-pol2qm74	8052	13	persist	persist	VB
cord-015021-pol2qm74	8052	14	despite	despite	IN
cord-015021-pol2qm74	8052	15	the	the	DT
cord-015021-pol2qm74	8052	16	use	use	NN
cord-015021-pol2qm74	8052	17	of	of	IN
cord-015021-pol2qm74	8052	18	gabexate	gabexate	NNP
cord-015021-pol2qm74	8052	19	mesilate	mesilate	NNP
cord-015021-pol2qm74	8052	20	.	.	.
cord-015021-pol2qm74	8053	1	Emergency	emergency	NN
cord-015021-pol2qm74	8053	2	Surgery	surgery	NN
cord-015021-pol2qm74	8053	3	,	,	,
cord-015021-pol2qm74	8053	4	Taipei	Taipei	NNP
cord-015021-pol2qm74	8053	5	Veterans	Veterans	NNPS
cord-015021-pol2qm74	8053	6	General	General	NNP
cord-015021-pol2qm74	8053	7	Hospital	Hospital	NNP
cord-015021-pol2qm74	8053	8	,	,	,
cord-015021-pol2qm74	8053	9	Taipei	Taipei	NNP
cord-015021-pol2qm74	8053	10	,	,	,
cord-015021-pol2qm74	8053	11	Taiwan	Taiwan	NNP
cord-015021-pol2qm74	8053	12	.	.	.
cord-015021-pol2qm74	8054	1	There	there	EX
cord-015021-pol2qm74	8054	2	are	be	VBP
cord-015021-pol2qm74	8054	3	2	2	CD
cord-015021-pol2qm74	8054	4	main	main	JJ
cord-015021-pol2qm74	8054	5	types	type	NNS
cord-015021-pol2qm74	8054	6	of	of	IN
cord-015021-pol2qm74	8054	7	bradykinin	bradykinin	NN
cord-015021-pol2qm74	8054	8	(	(	-LRB-
cord-015021-pol2qm74	8054	9	BK	BK	NNP
cord-015021-pol2qm74	8054	10	)	)	-RRB-
cord-015021-pol2qm74	8054	11	receptor	receptor	NN
cord-015021-pol2qm74	8054	12	,	,	,
cord-015021-pol2qm74	8054	13	namely	namely	RB
cord-015021-pol2qm74	8054	14	BK~	BK~	NNP
cord-015021-pol2qm74	8054	15	and	and	CC
cord-015021-pol2qm74	8054	16	BK	BK	NNP
cord-015021-pol2qm74	8054	17	z.	z.	NNP
cord-015021-pol2qm74	8055	1	The	the	DT
cord-015021-pol2qm74	8055	2	BK	BK	NNP
cord-015021-pol2qm74	8055	3	2	2	CD
cord-015021-pol2qm74	8055	4	receptor	receptor	NN
cord-015021-pol2qm74	8055	5	is	be	VBZ
cord-015021-pol2qm74	8055	6	constitutive	constitutive	JJ
cord-015021-pol2qm74	8055	7	.	.	.
cord-015021-pol2qm74	8056	1	The	the	DT
cord-015021-pol2qm74	8056	2	BK	BK	NNP
cord-015021-pol2qm74	8056	3	1	1	CD
cord-015021-pol2qm74	8056	4	receptor	receptor	NN
cord-015021-pol2qm74	8056	5	is	be	VBZ
cord-015021-pol2qm74	8056	6	also	also	RB
cord-015021-pol2qm74	8056	7	constitutive	constitutive	JJ
cord-015021-pol2qm74	8056	8	but	but	CC
cord-015021-pol2qm74	8056	9	in	in	IN
cord-015021-pol2qm74	8056	10	the	the	DT
cord-015021-pol2qm74	8056	11	majority	majority	NN
cord-015021-pol2qm74	8056	12	of	of	IN
cord-015021-pol2qm74	8056	13	cases	case	NNS
cord-015021-pol2qm74	8056	14	is	be	VBZ
cord-015021-pol2qm74	8056	15	inducible	inducible	JJ
cord-015021-pol2qm74	8056	16	and	and	CC
cord-015021-pol2qm74	8056	17	involved	involve	VBN
cord-015021-pol2qm74	8056	18	in	in	IN
cord-015021-pol2qm74	8056	19	chronic	chronic	JJ
cord-015021-pol2qm74	8056	20	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8056	21	syndromes	syndrome	NNS
cord-015021-pol2qm74	8056	22	such	such	JJ
cord-015021-pol2qm74	8056	23	as	as	IN
cord-015021-pol2qm74	8056	24	sepsis	sepsis	NN
cord-015021-pol2qm74	8056	25	,	,	,
cord-015021-pol2qm74	8056	26	hyperalgesia	hyperalgesia	NN
cord-015021-pol2qm74	8056	27	and	and	CC
cord-015021-pol2qm74	8056	28	airways	airways	NNP
cord-015021-pol2qm74	8056	29	hyperreactivty	hyperreactivty	NNP
cord-015021-pol2qm74	8056	30	in	in	IN
cord-015021-pol2qm74	8056	31	animals	animal	NNS
cord-015021-pol2qm74	8056	32	.	.	.
cord-015021-pol2qm74	8057	1	The	the	DT
cord-015021-pol2qm74	8057	2	mechanism(s	mechanism(s	NNP
cord-015021-pol2qm74	8057	3	)	)	-RRB-
cord-015021-pol2qm74	8057	4	involved	involve	VBN
cord-015021-pol2qm74	8057	5	in	in	IN
cord-015021-pol2qm74	8057	6	the	the	DT
cord-015021-pol2qm74	8057	7	upregulation	upregulation	NN
cord-015021-pol2qm74	8057	8	of	of	IN
cord-015021-pol2qm74	8057	9	the	the	DT
cord-015021-pol2qm74	8057	10	BK	BK	NNP
cord-015021-pol2qm74	8057	11	1	1	CD
cord-015021-pol2qm74	8057	12	receptor	receptor	NN
cord-015021-pol2qm74	8057	13	is	be	VBZ
cord-015021-pol2qm74	8057	14	unclear	unclear	JJ
cord-015021-pol2qm74	8057	15	,	,	,
cord-015021-pol2qm74	8057	16	however	however	RB
cord-015021-pol2qm74	8057	17	a	a	DT
cord-015021-pol2qm74	8057	18	variety	variety	NN
cord-015021-pol2qm74	8057	19	of	of	IN
cord-015021-pol2qm74	8057	20	agents	agent	NNS
cord-015021-pol2qm74	8057	21	including	include	VBG
cord-015021-pol2qm74	8057	22	LPS	LPS	NNP
cord-015021-pol2qm74	8057	23	,	,	,
cord-015021-pol2qm74	8057	24	E	E	NNP
cord-015021-pol2qm74	8057	25	Coil	Coil	NNP
cord-015021-pol2qm74	8057	26	and	and	CC
cord-015021-pol2qm74	8057	27	ILl	ILl	NNS
cord-015021-pol2qm74	8057	28	are	be	VBP
cord-015021-pol2qm74	8057	29	particularly	particularly	RB
cord-015021-pol2qm74	8057	30	efficacious	efficacious	JJ
cord-015021-pol2qm74	8057	31	in	in	IN
cord-015021-pol2qm74	8057	32	vitro	vitro	FW
cord-015021-pol2qm74	8057	33	and	and	CC
cord-015021-pol2qm74	8057	34	in	in	IN
cord-015021-pol2qm74	8057	35	vivo	vivo	NNP
cord-015021-pol2qm74	8057	36	.	.	.
cord-015021-pol2qm74	8058	1	ILl	ILl	NNP
cord-015021-pol2qm74	8058	2	and	and	CC
cord-015021-pol2qm74	8058	3	Bradykinin	Bradykinin	NNP
cord-015021-pol2qm74	8058	4	acting	act	VBG
cord-015021-pol2qm74	8058	5	at	at	IN
cord-015021-pol2qm74	8058	6	their	-PRON-	PRP$
cord-015021-pol2qm74	8058	7	respective	respective	JJ
cord-015021-pol2qm74	8058	8	receptors	receptor	NNS
cord-015021-pol2qm74	8058	9	are	be	VBP
cord-015021-pol2qm74	8058	10	believed	believe	VBN
cord-015021-pol2qm74	8058	11	to	to	TO
cord-015021-pol2qm74	8058	12	be	be	VB
cord-015021-pol2qm74	8058	13	involved	involve	VBN
cord-015021-pol2qm74	8058	14	in	in	IN
cord-015021-pol2qm74	8058	15	SIRS	SIRS	NNP
cord-015021-pol2qm74	8058	16	/	/	SYM
cord-015021-pol2qm74	8058	17	Sepsis	sepsis	NN
cord-015021-pol2qm74	8058	18	.	.	.
cord-015021-pol2qm74	8059	1	We	-PRON-	PRP
cord-015021-pol2qm74	8059	2	have	have	VBP
cord-015021-pol2qm74	8059	3	investigated	investigate	VBN
cord-015021-pol2qm74	8059	4	the	the	DT
cord-015021-pol2qm74	8059	5	effect	effect	NN
cord-015021-pol2qm74	8059	6	of	of	IN
cord-015021-pol2qm74	8059	7	antagonists	antagonist	NNS
cord-015021-pol2qm74	8059	8	at	at	IN
cord-015021-pol2qm74	8059	9	ILl	ILl	NNP
cord-015021-pol2qm74	8059	10	(	(	-LRB-
cord-015021-pol2qm74	8059	11	Antril	Antril	NNP
cord-015021-pol2qm74	8059	12	)	)	-RRB-
cord-015021-pol2qm74	8059	13	,	,	,
cord-015021-pol2qm74	8059	14	BK	BK	NNP
cord-015021-pol2qm74	8059	15	2	2	CD
cord-015021-pol2qm74	8059	16	(	(	-LRB-
cord-015021-pol2qm74	8059	17	Bradycor	Bradycor	NNP
cord-015021-pol2qm74	8059	18	[	[	-LRB-
cord-015021-pol2qm74	8059	19	CP-0127]),BK~	CP-0127]),BK~	NNP
cord-015021-pol2qm74	8059	20	(	(	-LRB-
cord-015021-pol2qm74	8059	21	CP-0298	CP-0298	NNS
cord-015021-pol2qm74	8059	22	)	)	-RRB-
cord-015021-pol2qm74	8059	23	and	and	CC
cord-015021-pol2qm74	8059	24	BKz	BKz	NNP
cord-015021-pol2qm74	8059	25	/	/	SYM
cord-015021-pol2qm74	8059	26	BK	BK	NNP
cord-015021-pol2qm74	8059	27	1	1	CD
cord-015021-pol2qm74	8059	28	(	(	-LRB-
cord-015021-pol2qm74	8059	29	CP-0364	CP-0364	NNP
cord-015021-pol2qm74	8059	30	)	)	-RRB-
cord-015021-pol2qm74	8059	31	receptors	receptor	NNS
cord-015021-pol2qm74	8059	32	on	on	IN
cord-015021-pol2qm74	8059	33	the	the	DT
cord-015021-pol2qm74	8059	34	de	de	FW
cord-015021-pol2qm74	8059	35	novo	novo	NNP
cord-015021-pol2qm74	8059	36	generation	generation	NN
cord-015021-pol2qm74	8059	37	of	of	IN
cord-015021-pol2qm74	8059	38	BK~	bk~	JJ
cord-015021-pol2qm74	8059	39	receptors	receptor	NNS
cord-015021-pol2qm74	8059	40	(	(	-LRB-
cord-015021-pol2qm74	8059	41	reflected	reflect	VBN
cord-015021-pol2qm74	8059	42	by	by	IN
cord-015021-pol2qm74	8059	43	hypotensive	hypotensive	JJ
cord-015021-pol2qm74	8059	44	responses	response	NNS
cord-015021-pol2qm74	8059	45	to	to	IN
cord-015021-pol2qm74	8059	46	a	a	DT
cord-015021-pol2qm74	8059	47	BK	BK	NNP
cord-015021-pol2qm74	8059	48	1	1	CD
cord-015021-pol2qm74	8059	49	agonist	agonist	NN
cord-015021-pol2qm74	8059	50	)	)	-RRB-
cord-015021-pol2qm74	8059	51	in	in	IN
cord-015021-pol2qm74	8059	52	the	the	DT
cord-015021-pol2qm74	8059	53	LPS	LPS	NNP
cord-015021-pol2qm74	8059	54	-	-	HYPH
cord-015021-pol2qm74	8059	55	treated	treat	VBN
cord-015021-pol2qm74	8059	56	(	(	-LRB-
cord-015021-pol2qm74	8059	57	10ug	10ug	NN
cord-015021-pol2qm74	8059	58	iv	iv	CD
cord-015021-pol2qm74	8059	59	)	)	-RRB-
cord-015021-pol2qm74	8059	60	rabbit	rabbit	NN
cord-015021-pol2qm74	8059	61	.	.	.
cord-015021-pol2qm74	8060	1	In	in	IN
cord-015021-pol2qm74	8060	2	LPS	lp	NNS
cord-015021-pol2qm74	8060	3	treated	treat	VBD
cord-015021-pol2qm74	8060	4	rabbits	rabbit	NNS
cord-015021-pol2qm74	8060	5	hypotensive	hypotensive	JJ
cord-015021-pol2qm74	8060	6	responses	response	NNS
cord-015021-pol2qm74	8060	7	to	to	IN
cord-015021-pol2qm74	8060	8	BK~	bk~	VB
cord-015021-pol2qm74	8060	9	but	but	CC
cord-015021-pol2qm74	8060	10	not	not	RB
cord-015021-pol2qm74	8060	11	BK	BK	NNP
cord-015021-pol2qm74	8060	12	2	2	CD
cord-015021-pol2qm74	8060	13	agonists	agonist	NNS
cord-015021-pol2qm74	8060	14	increased	increase	VBD
cord-015021-pol2qm74	8060	15	with	with	IN
cord-015021-pol2qm74	8060	16	time	time	NN
cord-015021-pol2qm74	8060	17	and	and	CC
cord-015021-pol2qm74	8060	18	at	at	IN
cord-015021-pol2qm74	8060	19	time	time	NN
cord-015021-pol2qm74	8060	20	210min	210min	CD
cord-015021-pol2qm74	8060	21	appeared	appear	VBD
cord-015021-pol2qm74	8060	22	maximally	maximally	RB
cord-015021-pol2qm74	8060	23	induced	induce	VBN
cord-015021-pol2qm74	8060	24	.	.	.
cord-015021-pol2qm74	8061	1	Constant	constant	JJ
cord-015021-pol2qm74	8061	2	iv	iv	IN
cord-015021-pol2qm74	8061	3	infusions	infusion	NNS
cord-015021-pol2qm74	8061	4	of	of	IN
cord-015021-pol2qm74	8061	5	CP-0127	CP-0127	NNP
cord-015021-pol2qm74	8061	6	blocked	block	VBD
cord-015021-pol2qm74	8061	7	BK	BK	NNP
cord-015021-pol2qm74	8061	8	2	2	CD
cord-015021-pol2qm74	8061	9	but	but	CC
cord-015021-pol2qm74	8061	10	not	not	RB
cord-015021-pol2qm74	8061	11	BK~	BK~	VBN
cord-015021-pol2qm74	8061	12	and	and	CC
cord-015021-pol2qm74	8061	13	CP-0298	CP-0298	NNS
cord-015021-pol2qm74	8061	14	BK~	BK~	VBN
cord-015021-pol2qm74	8062	1	but	but	CC
cord-015021-pol2qm74	8062	2	not	not	RB
cord-015021-pol2qm74	8062	3	BK	BK	NNP
cord-015021-pol2qm74	8062	4	2	2	CD
cord-015021-pol2qm74	8062	5	responses	response	NNS
cord-015021-pol2qm74	8062	6	.	.	.
cord-015021-pol2qm74	8063	1	CP-0364,CP-0127+CP-0298	CP-0364,CP-0127+CP-0298	NNPS
cord-015021-pol2qm74	8063	2	and	and	CC
cord-015021-pol2qm74	8063	3	Antril+CP-0364	Antril+CP-0364	NNP
cord-015021-pol2qm74	8063	4	blocked	block	VBD
cord-015021-pol2qm74	8063	5	both	both	DT
cord-015021-pol2qm74	8063	6	BK	BK	NNP
cord-015021-pol2qm74	8063	7	2	2	CD
cord-015021-pol2qm74	8063	8	and	and	CC
cord-015021-pol2qm74	8063	9	BK~	bk~	JJ
cord-015021-pol2qm74	8063	10	responses	response	NNS
cord-015021-pol2qm74	8063	11	.	.	.
cord-015021-pol2qm74	8064	1	Antril	Antril	NNP
cord-015021-pol2qm74	8064	2	alone	alone	RB
cord-015021-pol2qm74	8064	3	had	have	VBD
cord-015021-pol2qm74	8064	4	no	no	DT
cord-015021-pol2qm74	8064	5	effect	effect	NN
cord-015021-pol2qm74	8064	6	on	on	IN
cord-015021-pol2qm74	8064	7	BK	BK	NNP
cord-015021-pol2qm74	8064	8	2	2	CD
cord-015021-pol2qm74	8064	9	or	or	CC
cord-015021-pol2qm74	8064	10	BK~	bk~	JJ
cord-015021-pol2qm74	8064	11	responses	response	NNS
cord-015021-pol2qm74	8064	12	.	.	.
cord-015021-pol2qm74	8065	1	Within	within	IN
cord-015021-pol2qm74	8065	2	30	30	CD
cord-015021-pol2qm74	8065	3	-	-	SYM
cord-015021-pol2qm74	8065	4	60	60	CD
cord-015021-pol2qm74	8065	5	min	min	NN
cord-015021-pol2qm74	8065	6	after	after	IN
cord-015021-pol2qm74	8065	7	stopping	stop	VBG
cord-015021-pol2qm74	8065	8	the	the	DT
cord-015021-pol2qm74	8065	9	infusions	infusion	NNS
cord-015021-pol2qm74	8065	10	of	of	IN
cord-015021-pol2qm74	8065	11	antagonists	antagonist	NNS
cord-015021-pol2qm74	8065	12	the	the	DT
cord-015021-pol2qm74	8065	13	responses	response	NNS
cord-015021-pol2qm74	8065	14	to	to	TO
cord-015021-pol2qm74	8065	15	BK~	BK~	NNP
cord-015021-pol2qm74	8065	16	and	and	CC
cord-015021-pol2qm74	8065	17	BK	BK	NNP
cord-015021-pol2qm74	8065	18	z	z	NNP
cord-015021-pol2qm74	8065	19	agonists	agonist	NNS
cord-015021-pol2qm74	8065	20	were	be	VBD
cord-015021-pol2qm74	8065	21	the	the	DT
cord-015021-pol2qm74	8065	22	same	same	JJ
cord-015021-pol2qm74	8065	23	as	as	IN
cord-015021-pol2qm74	8065	24	those	those	DT
cord-015021-pol2qm74	8065	25	in	in	IN
cord-015021-pol2qm74	8065	26	nonantagonist	nonantagonist	NN
cord-015021-pol2qm74	8065	27	infused	infuse	VBN
cord-015021-pol2qm74	8065	28	rabbits	rabbit	NNS
cord-015021-pol2qm74	8065	29	.	.	.
cord-015021-pol2qm74	8066	1	These	these	DT
cord-015021-pol2qm74	8066	2	results	result	NNS
cord-015021-pol2qm74	8066	3	indicate	indicate	VBP
cord-015021-pol2qm74	8066	4	,	,	,
cord-015021-pol2qm74	8066	5	at	at	IN
cord-015021-pol2qm74	8066	6	least	least	JJS
cord-015021-pol2qm74	8066	7	in	in	IN
cord-015021-pol2qm74	8066	8	the	the	DT
cord-015021-pol2qm74	8066	9	LPS	LPS	NNP
cord-015021-pol2qm74	8066	10	-	-	HYPH
cord-015021-pol2qm74	8066	11	treated	treat	VBN
cord-015021-pol2qm74	8066	12	rabbit	rabbit	NN
cord-015021-pol2qm74	8066	13	,	,	,
cord-015021-pol2qm74	8066	14	that	that	IN
cord-015021-pol2qm74	8066	15	neither	neither	CC
cord-015021-pol2qm74	8066	16	BK2,BK	bk2,bk	NN
cord-015021-pol2qm74	8066	17	~	~	NFP
cord-015021-pol2qm74	8066	18	or	or	CC
cord-015021-pol2qm74	8066	19	ILl	ill	JJ
cord-015021-pol2qm74	8066	20	receptors	receptor	NNS
cord-015021-pol2qm74	8066	21	alone	alone	RB
cord-015021-pol2qm74	8066	22	or	or	CC
cord-015021-pol2qm74	8066	23	in	in	IN
cord-015021-pol2qm74	8066	24	combination	combination	NN
cord-015021-pol2qm74	8066	25	,	,	,
cord-015021-pol2qm74	8066	26	are	be	VBP
cord-015021-pol2qm74	8066	27	involved	involve	VBN
cord-015021-pol2qm74	8066	28	in	in	IN
cord-015021-pol2qm74	8066	29	the	the	DT
cord-015021-pol2qm74	8066	30	de	de	FW
cord-015021-pol2qm74	8066	31	novo	novo	NNP
cord-015021-pol2qm74	8066	32	generation	generation	NN
cord-015021-pol2qm74	8066	33	of	of	IN
cord-015021-pol2qm74	8066	34	BK	BK	NNP
cord-015021-pol2qm74	8066	35	1	1	CD
cord-015021-pol2qm74	8066	36	receptors	receptor	NNS
cord-015021-pol2qm74	8066	37	.	.	.
cord-015021-pol2qm74	8067	1	In	in	IN
cord-015021-pol2qm74	8067	2	vitro	vitro	FW
cord-015021-pol2qm74	8067	3	studies	study	NNS
cord-015021-pol2qm74	8067	4	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	8067	5	that	that	IN
cord-015021-pol2qm74	8067	6	beth	beth	NNP
cord-015021-pol2qm74	8067	7	Bradycor	Bradycor	NNP
cord-015021-pol2qm74	8067	8	and	and	CC
cord-015021-pol2qm74	8067	9	CP-0364	CP-0364	NNP
cord-015021-pol2qm74	8067	10	(	(	-LRB-
cord-015021-pol2qm74	8067	11	but	but	CC
cord-015021-pol2qm74	8067	12	not	not	RB
cord-015021-pol2qm74	8067	13	Antril	Antril	NNP
cord-015021-pol2qm74	8067	14	)	)	-RRB-
cord-015021-pol2qm74	8067	15	were	be	VBD
cord-015021-pol2qm74	8067	16	antagonists	antagonist	NNS
cord-015021-pol2qm74	8067	17	at	at	IN
cord-015021-pol2qm74	8067	18	both	both	DT
cord-015021-pol2qm74	8067	19	BK	BK	NNP
cord-015021-pol2qm74	8067	20	z	z	NNP
cord-015021-pol2qm74	8067	21	and	and	CC
cord-015021-pol2qm74	8067	22	BK~	bk~	JJ
cord-015021-pol2qm74	8067	23	receptors	receptor	NNS
cord-015021-pol2qm74	8067	24	.	.	.
cord-015021-pol2qm74	8068	1	If	if	IN
cord-015021-pol2qm74	8068	2	both	both	DT
cord-015021-pol2qm74	8068	3	BK	BK	NNP
cord-015021-pol2qm74	8068	4	z	z	NNP
cord-015021-pol2qm74	8068	5	and	and	CC
cord-015021-pol2qm74	8068	6	BK	BK	NNP
cord-015021-pol2qm74	8068	7	1	1	CD
cord-015021-pol2qm74	8068	8	receptors	receptor	NNS
cord-015021-pol2qm74	8068	9	are	be	VBP
cord-015021-pol2qm74	8068	10	significantly	significantly	RB
cord-015021-pol2qm74	8068	11	involved	involve	VBN
cord-015021-pol2qm74	8068	12	in	in	IN
cord-015021-pol2qm74	8068	13	chronic	chronic	JJ
cord-015021-pol2qm74	8068	14	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8068	15	situations	situation	NNS
cord-015021-pol2qm74	8068	16	in	in	IN
cord-015021-pol2qm74	8068	17	man	man	NN
cord-015021-pol2qm74	8068	18	such	such	JJ
cord-015021-pol2qm74	8068	19	as	as	IN
cord-015021-pol2qm74	8068	20	SIRS	SIRS	NNP
cord-015021-pol2qm74	8068	21	/	/	SYM
cord-015021-pol2qm74	8068	22	sepsis	sepsis	NN
cord-015021-pol2qm74	8069	1	then	then	RB
cord-015021-pol2qm74	8069	2	the	the	DT
cord-015021-pol2qm74	8069	3	rationale	rationale	NN
cord-015021-pol2qm74	8069	4	for	for	IN
cord-015021-pol2qm74	8069	5	the	the	DT
cord-015021-pol2qm74	8069	6	use	use	NN
cord-015021-pol2qm74	8069	7	of	of	IN
cord-015021-pol2qm74	8069	8	compounds	compound	NNS
cord-015021-pol2qm74	8069	9	such	such	JJ
cord-015021-pol2qm74	8069	10	as	as	IN
cord-015021-pol2qm74	8069	11	Bradycor	Bradycor	NNP
cord-015021-pol2qm74	8069	12	or	or	CC
cord-015021-pol2qm74	8069	13	CP-0364	CP-0364	NNP
cord-015021-pol2qm74	8069	14	is	be	VBZ
cord-015021-pol2qm74	8069	15	clear	clear	JJ
cord-015021-pol2qm74	8069	16	.	.	.
cord-015021-pol2qm74	8070	1	Infection	infection	NN
cord-015021-pol2qm74	8070	2	is	be	VBZ
cord-015021-pol2qm74	8070	3	a	a	DT
cord-015021-pol2qm74	8070	4	major	major	JJ
cord-015021-pol2qm74	8070	5	cause	cause	NN
cord-015021-pol2qm74	8070	6	of	of	IN
cord-015021-pol2qm74	8070	7	or	or	CC
cord-015021-pol2qm74	8070	8	contributor	contributor	NN
cord-015021-pol2qm74	8070	9	for	for	IN
cord-015021-pol2qm74	8070	10	morbidity	morbidity	NN
cord-015021-pol2qm74	8070	11	and	and	CC
cord-015021-pol2qm74	8070	12	mortality	mortality	NN
cord-015021-pol2qm74	8070	13	in	in	IN
cord-015021-pol2qm74	8070	14	liver	liver	NN
cord-015021-pol2qm74	8070	15	transplant	transplant	NN
cord-015021-pol2qm74	8070	16	recipients	recipient	NNS
cord-015021-pol2qm74	8070	17	.	.	.
cord-015021-pol2qm74	8071	1	Effectiveness	effectiveness	NN
cord-015021-pol2qm74	8071	2	of	of	IN
cord-015021-pol2qm74	8071	3	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	8071	4	and	and	CC
cord-015021-pol2qm74	8071	5	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8071	6	protocols	protocol	NNS
cord-015021-pol2qm74	8071	7	is	be	VBZ
cord-015021-pol2qm74	8071	8	important	important	JJ
cord-015021-pol2qm74	8071	9	for	for	IN
cord-015021-pol2qm74	8071	10	the	the	DT
cord-015021-pol2qm74	8071	11	success	success	NN
cord-015021-pol2qm74	8071	12	of	of	IN
cord-015021-pol2qm74	8071	13	liver	liver	NN
cord-015021-pol2qm74	8071	14	transplantation	transplantation	NN
cord-015021-pol2qm74	8071	15	(	(	-LRB-
cord-015021-pol2qm74	8071	16	OLT	OLT	NNP
cord-015021-pol2qm74	8071	17	)	)	-RRB-
cord-015021-pol2qm74	8071	18	.	.	.
cord-015021-pol2qm74	8072	1	SDD	SDD	NNP
cord-015021-pol2qm74	8072	2	is	be	VBZ
cord-015021-pol2qm74	8072	3	used	use	VBN
cord-015021-pol2qm74	8072	4	as	as	IN
cord-015021-pol2qm74	8072	5	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	8072	6	for	for	IN
cord-015021-pol2qm74	8072	7	reduction	reduction	NN
cord-015021-pol2qm74	8072	8	of	of	IN
cord-015021-pol2qm74	8072	9	infection	infection	NN
cord-015021-pol2qm74	8072	10	caused	cause	VBN
cord-015021-pol2qm74	8072	11	by	by	IN
cord-015021-pol2qm74	8072	12	Gram	Gram	NNP
cord-015021-pol2qm74	8072	13	negative	negative	JJ
cord-015021-pol2qm74	8072	14	or	or	CC
cord-015021-pol2qm74	8072	15	fungal	fungal	JJ
cord-015021-pol2qm74	8072	16	microorganisms	microorganism	NNS
cord-015021-pol2qm74	8072	17	.	.	.
cord-015021-pol2qm74	8073	1	Between	between	IN
cord-015021-pol2qm74	8073	2	September	September	NNP
cord-015021-pol2qm74	8073	3	1988	1988	CD
cord-015021-pol2qm74	8073	4	and	and	CC
cord-015021-pol2qm74	8073	5	July	July	NNP
cord-015021-pol2qm74	8073	6	1993	1993	CD
cord-015021-pol2qm74	8073	7	400	400	CD
cord-015021-pol2qm74	8073	8	OLT	OLT	NNP
cord-015021-pol2qm74	8073	9	's	's	POS
cord-015021-pol2qm74	8073	10	in	in	IN
cord-015021-pol2qm74	8073	11	368	368	CD
cord-015021-pol2qm74	8073	12	patients	patient	NNS
cord-015021-pol2qm74	8073	13	were	be	VBD
cord-015021-pol2qm74	8073	14	performed	perform	VBN
cord-015021-pol2qm74	8073	15	at	at	IN
cord-015021-pol2qm74	8073	16	our	-PRON-	PRP$
cord-015021-pol2qm74	8073	17	department	department	NN
cord-015021-pol2qm74	8073	18	.	.	.
cord-015021-pol2qm74	8074	1	The	the	DT
cord-015021-pol2qm74	8074	2	actuarial	actuarial	JJ
cord-015021-pol2qm74	8074	3	1-year	1-year	CD
cord-015021-pol2qm74	8074	4	patient	patient	JJ
cord-015021-pol2qm74	8074	5	survival	survival	NN
cord-015021-pol2qm74	8074	6	is	be	VBZ
cord-015021-pol2qm74	8074	7	90	90	CD
cord-015021-pol2qm74	8074	8	%	%	NN
cord-015021-pol2qm74	8074	9	.	.	.
cord-015021-pol2qm74	8075	1	Infection	infection	NN
cord-015021-pol2qm74	8075	2	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	8075	3	is	be	VBZ
cord-015021-pol2qm74	8075	4	started	start	VBN
cord-015021-pol2qm74	8075	5	with	with	IN
cord-015021-pol2qm74	8075	6	SDD	SDD	NNP
cord-015021-pol2qm74	8075	7	and	and	CC
cord-015021-pol2qm74	8075	8	ciprofloxacin	ciprofloxacin	NN
cord-015021-pol2qm74	8075	9	once	once	IN
cord-015021-pol2qm74	8075	10	the	the	DT
cord-015021-pol2qm74	8075	11	patient	patient	NN
cord-015021-pol2qm74	8075	12	is	be	VBZ
cord-015021-pol2qm74	8075	13	accepted	accept	VBN
cord-015021-pol2qm74	8075	14	as	as	IN
cord-015021-pol2qm74	8075	15	an	an	DT
cord-015021-pol2qm74	8075	16	OLT	OLT	NNP
cord-015021-pol2qm74	8075	17	candidate	candidate	NN
cord-015021-pol2qm74	8075	18	.	.	.
cord-015021-pol2qm74	8076	1	Perioperatively	Perioperatively	NNP
cord-015021-pol2qm74	8076	2	metronidazol	metronidazol	NNP
cord-015021-pol2qm74	8076	3	,	,	,
cord-015021-pol2qm74	8076	4	tobramycin	tobramycin	NNPS
cord-015021-pol2qm74	8076	5	and	and	CC
cord-015021-pol2qm74	8076	6	cefotaxim	cefotaxim	NNP
cord-015021-pol2qm74	8076	7	,	,	,
cord-015021-pol2qm74	8076	8	postoperatively	postoperatively	RB
cord-015021-pol2qm74	8076	9	cotrimoxazol	cotrimoxazol	NNP
cord-015021-pol2qm74	8076	10	are	be	VBP
cord-015021-pol2qm74	8076	11	prescribed	prescribe	VBN
cord-015021-pol2qm74	8076	12	additionally	additionally	RB
cord-015021-pol2qm74	8076	13	.	.	.
cord-015021-pol2qm74	8077	1	The	the	DT
cord-015021-pol2qm74	8077	2	table	table	NN
cord-015021-pol2qm74	8077	3	shows	show	VBZ
cord-015021-pol2qm74	8077	4	Pneumonia	pneumonia	NN
cord-015021-pol2qm74	8077	5	,	,	,
cord-015021-pol2qm74	8077	6	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8077	7	,	,	,
cord-015021-pol2qm74	8077	8	major	major	JJ
cord-015021-pol2qm74	8077	9	wound	wound	NN
cord-015021-pol2qm74	8077	10	and	and	CC
cord-015021-pol2qm74	8077	11	urinary	urinary	JJ
cord-015021-pol2qm74	8077	12	tract	tract	NN
cord-015021-pol2qm74	8077	13	infection	infection	NN
cord-015021-pol2qm74	8077	14	are	be	VBP
cord-015021-pol2qm74	8077	15	common	common	JJ
cord-015021-pol2qm74	8077	16	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	8077	17	infections	infection	NNS
cord-015021-pol2qm74	8077	18	following	follow	VBG
cord-015021-pol2qm74	8077	19	severe	severe	JJ
cord-015021-pol2qm74	8077	20	injury	injury	NN
cord-015021-pol2qm74	8077	21	.	.	.
cord-015021-pol2qm74	8078	1	In	in	IN
cord-015021-pol2qm74	8078	2	a	a	DT
cord-015021-pol2qm74	8078	3	series	series	NN
cord-015021-pol2qm74	8078	4	of	of	IN
cord-015021-pol2qm74	8078	5	severely	severely	RB
cord-015021-pol2qm74	8078	6	injured	injure	VBN
cord-015021-pol2qm74	8078	7	patients	patient	NNS
cord-015021-pol2qm74	8078	8	from	from	IN
cord-015021-pol2qm74	8078	9	the	the	DT
cord-015021-pol2qm74	8078	10	University	University	NNP
cord-015021-pol2qm74	8078	11	of	of	IN
cord-015021-pol2qm74	8078	12	Louisville	Louisville	NNP
cord-015021-pol2qm74	8078	13	Hospital	Hospital	NNP
cord-015021-pol2qm74	8078	14	,	,	,
cord-015021-pol2qm74	8078	15	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8078	16	was	be	VBD
cord-015021-pol2qm74	8078	17	the	the	DT
cord-015021-pol2qm74	8078	18	most	most	RBS
cord-015021-pol2qm74	8078	19	common	common	JJ
cord-015021-pol2qm74	8078	20	infection	infection	NN
cord-015021-pol2qm74	8078	21	followed	follow	VBN
cord-015021-pol2qm74	8078	22	by	by	IN
cord-015021-pol2qm74	8078	23	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8078	24	,	,	,
cord-015021-pol2qm74	8078	25	intra	intra	JJ
cord-015021-pol2qm74	8078	26	-	-	JJ
cord-015021-pol2qm74	8078	27	abdominal	abdominal	JJ
cord-015021-pol2qm74	8078	28	abscess	abscess	NN
cord-015021-pol2qm74	8078	29	formation	formation	NN
cord-015021-pol2qm74	8078	30	and	and	CC
cord-015021-pol2qm74	8078	31	burn	burn	VB
cord-015021-pol2qm74	8078	32	wound	wound	NN
cord-015021-pol2qm74	8078	33	infection	infection	NN
cord-015021-pol2qm74	8078	34	.	.	.
cord-015021-pol2qm74	8079	1	Pneumonia	pneumonia	NN
cord-015021-pol2qm74	8079	2	is	be	VBZ
cord-015021-pol2qm74	8079	3	actually	actually	RB
cord-015021-pol2qm74	8079	4	the	the	DT
cord-015021-pol2qm74	8079	5	leading	leading	JJ
cord-015021-pol2qm74	8079	6	cause	cause	NN
cord-015021-pol2qm74	8079	7	of	of	IN
cord-015021-pol2qm74	8079	8	death	death	NN
cord-015021-pol2qm74	8079	9	from	from	IN
cord-015021-pol2qm74	8079	10	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	8079	11	infection	infection	NN
cord-015021-pol2qm74	8079	12	.	.	.
cord-015021-pol2qm74	8080	1	These	these	DT
cord-015021-pol2qm74	8080	2	are	be	VBP
cord-015021-pol2qm74	8080	3	defined	define	VBN
cord-015021-pol2qm74	8080	4	as	as	IN
cord-015021-pol2qm74	8080	5	occurring	occur	VBG
cord-015021-pol2qm74	8080	6	from	from	IN
cord-015021-pol2qm74	8080	7	48	48	CD
cord-015021-pol2qm74	8080	8	to	to	TO
cord-015021-pol2qm74	8080	9	72	72	CD
cord-015021-pol2qm74	8080	10	hours	hour	NNS
cord-015021-pol2qm74	8080	11	after	after	IN
cord-015021-pol2qm74	8080	12	hospital	hospital	NN
cord-015021-pol2qm74	8080	13	admission	admission	NN
cord-015021-pol2qm74	8080	14	.	.	.
cord-015021-pol2qm74	8081	1	This	this	DT
cord-015021-pol2qm74	8081	2	definition	definition	NN
cord-015021-pol2qm74	8081	3	has	have	VBZ
cord-015021-pol2qm74	8081	4	important	important	JJ
cord-015021-pol2qm74	8081	5	implications	implication	NNS
cord-015021-pol2qm74	8081	6	for	for	IN
cord-015021-pol2qm74	8081	7	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	8081	8	therapy	therapy	NN
cord-015021-pol2qm74	8081	9	because	because	IN
cord-015021-pol2qm74	8081	10	the	the	DT
cord-015021-pol2qm74	8081	11	likely	likely	JJ
cord-015021-pol2qm74	8081	12	pathogens	pathogen	NNS
cord-015021-pol2qm74	8081	13	and	and	CC
cord-015021-pol2qm74	8081	14	their	-PRON-	PRP$
cord-015021-pol2qm74	8081	15	respective	respective	JJ
cord-015021-pol2qm74	8081	16	sensitivities	sensitivity	NNS
cord-015021-pol2qm74	8081	17	are	be	VBP
cord-015021-pol2qm74	8081	18	different	different	JJ
cord-015021-pol2qm74	8081	19	for	for	IN
cord-015021-pol2qm74	8081	20	community	community	NN
cord-015021-pol2qm74	8081	21	acquired	acquire	VBD
cord-015021-pol2qm74	8081	22	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8081	23	.	.	.
cord-015021-pol2qm74	8082	1	The	the	DT
cord-015021-pol2qm74	8082	2	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8082	3	of	of	IN
cord-015021-pol2qm74	8082	4	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	8082	5	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8082	6	is	be	VBZ
cord-015021-pol2qm74	8082	7	difficult	difficult	JJ
cord-015021-pol2qm74	8082	8	following	follow	VBG
cord-015021-pol2qm74	8082	9	major	major	JJ
cord-015021-pol2qm74	8082	10	injury	injury	NN
cord-015021-pol2qm74	8082	11	as	as	IN
cord-015021-pol2qm74	8082	12	many	many	JJ
cord-015021-pol2qm74	8082	13	patients	patient	NNS
cord-015021-pol2qm74	8082	14	will	will	MD
cord-015021-pol2qm74	8082	15	have	have	VB
cord-015021-pol2qm74	8082	16	pre	pre	JJ
cord-015021-pol2qm74	8082	17	-	-	JJ
cord-015021-pol2qm74	8082	18	existing	existing	JJ
cord-015021-pol2qm74	8082	19	fever	fever	NN
cord-015021-pol2qm74	8082	20	,	,	,
cord-015021-pol2qm74	8082	21	leukocytosis	leukocytosis	NN
cord-015021-pol2qm74	8082	22	,	,	,
cord-015021-pol2qm74	8082	23	tachypnea	tachypnea	NNP
cord-015021-pol2qm74	8082	24	,	,	,
cord-015021-pol2qm74	8082	25	and	and	CC
cord-015021-pol2qm74	8082	26	chest	chest	NN
cord-015021-pol2qm74	8082	27	X	x	NN
cord-015021-pol2qm74	8082	28	-	-	NN
cord-015021-pol2qm74	8082	29	ray	ray	JJ
cord-015021-pol2qm74	8082	30	changes	change	NNS
cord-015021-pol2qm74	8082	31	.	.	.
cord-015021-pol2qm74	8083	1	Reliance	reliance	NN
cord-015021-pol2qm74	8083	2	on	on	IN
cord-015021-pol2qm74	8083	3	sputum	sputum	NN
cord-015021-pol2qm74	8083	4	gram	gram	NN
cord-015021-pol2qm74	8083	5	stain	stain	NN
cord-015021-pol2qm74	8083	6	and	and	CC
cord-015021-pol2qm74	8083	7	culture	culture	NN
cord-015021-pol2qm74	8083	8	is	be	VBZ
cord-015021-pol2qm74	8083	9	important	important	JJ
cord-015021-pol2qm74	8083	10	and	and	CC
cord-015021-pol2qm74	8083	11	best	well	RBS
cord-015021-pol2qm74	8083	12	obtained	obtain	VBN
cord-015021-pol2qm74	8083	13	by	by	IN
cord-015021-pol2qm74	8083	14	a	a	DT
cord-015021-pol2qm74	8083	15	bronchoalveolar	bronchoalveolar	JJ
cord-015021-pol2qm74	8083	16	lavage	lavage	NN
cord-015021-pol2qm74	8083	17	or	or	CC
cord-015021-pol2qm74	8083	18	protected	protect	VBN
cord-015021-pol2qm74	8083	19	specimen	specimen	JJ
cord-015021-pol2qm74	8083	20	brush	brush	NN
cord-015021-pol2qm74	8083	21	during	during	IN
cord-015021-pol2qm74	8083	22	bronchoscopy	bronchoscopy	NN
cord-015021-pol2qm74	8083	23	.	.	.
cord-015021-pol2qm74	8084	1	Predisposing	predispose	VBG
cord-015021-pol2qm74	8084	2	risk	risk	NN
cord-015021-pol2qm74	8084	3	factors	factor	NNS
cord-015021-pol2qm74	8084	4	include	include	VBP
cord-015021-pol2qm74	8084	5	severe	severe	JJ
cord-015021-pol2qm74	8084	6	head	head	NN
cord-015021-pol2qm74	8084	7	injury	injury	NN
cord-015021-pol2qm74	8084	8	,	,	,
cord-015021-pol2qm74	8084	9	emergent	emergent	JJ
cord-015021-pol2qm74	8084	10	intubation	intubation	NN
cord-015021-pol2qm74	8084	11	and	and	CC
cord-015021-pol2qm74	8084	12	shock	shock	NN
cord-015021-pol2qm74	8084	13	,	,	,
cord-015021-pol2qm74	8084	14	and	and	CC
cord-015021-pol2qm74	8084	15	such	such	JJ
cord-015021-pol2qm74	8084	16	patients	patient	NNS
cord-015021-pol2qm74	8084	17	have	have	VBP
cord-015021-pol2qm74	8084	18	been	be	VBN
cord-015021-pol2qm74	8084	19	shown	show	VBN
cord-015021-pol2qm74	8084	20	to	to	TO
cord-015021-pol2qm74	8084	21	benefit	benefit	VB
cord-015021-pol2qm74	8084	22	by	by	IN
cord-015021-pol2qm74	8084	23	early	early	JJ
cord-015021-pol2qm74	8084	24	tracheostomy	tracheostomy	NN
cord-015021-pol2qm74	8084	25	.	.	.
cord-015021-pol2qm74	8085	1	Staph	Staph	NNP
cord-015021-pol2qm74	8085	2	aureus	aureus	NN
cord-015021-pol2qm74	8085	3	has	have	VBZ
cord-015021-pol2qm74	8085	4	been	be	VBN
cord-015021-pol2qm74	8085	5	the	the	DT
cord-015021-pol2qm74	8085	6	most	most	RBS
cord-015021-pol2qm74	8085	7	common	common	JJ
cord-015021-pol2qm74	8085	8	pathogen	pathogen	NN
cord-015021-pol2qm74	8085	9	isolated	isolate	VBN
cord-015021-pol2qm74	8085	10	from	from	IN
cord-015021-pol2qm74	8085	11	the	the	DT
cord-015021-pol2qm74	8085	12	sputum	sputum	NN
cord-015021-pol2qm74	8085	13	and	and	CC
cord-015021-pol2qm74	8085	14	the	the	DT
cord-015021-pol2qm74	8085	15	remainder	remainder	NN
cord-015021-pol2qm74	8085	16	gram	gram	NN
cord-015021-pol2qm74	8085	17	-	-	HYPH
cord-015021-pol2qm74	8085	18	negative	negative	JJ
cord-015021-pol2qm74	8085	19	organisms	organism	NNS
cord-015021-pol2qm74	8085	20	with	with	IN
cord-015021-pol2qm74	8085	21	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	8085	22	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	8085	23	,	,	,
cord-015021-pol2qm74	8085	24	and	and	CC
cord-015021-pol2qm74	8085	25	Klebsiella	Klebsiella	NNP
cord-015021-pol2qm74	8085	26	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8085	27	predominating	predominate	VBG
cord-015021-pol2qm74	8085	28	.	.	.
cord-015021-pol2qm74	8086	1	Bacteria	Bacteria	NNS
cord-015021-pol2qm74	8086	2	recovered	recover	VBN
cord-015021-pol2qm74	8086	3	by	by	IN
cord-015021-pol2qm74	8086	4	site	site	NN
cord-015021-pol2qm74	8086	5	as	as	RB
cord-015021-pol2qm74	8086	6	well	well	RB
cord-015021-pol2qm74	8086	7	as	as	IN
cord-015021-pol2qm74	8086	8	by	by	IN
cord-015021-pol2qm74	8086	9	intensive	intensive	JJ
cord-015021-pol2qm74	8086	10	care	care	NN
cord-015021-pol2qm74	8086	11	unit	unit	NN
cord-015021-pol2qm74	8086	12	is	be	VBZ
cord-015021-pol2qm74	8086	13	published	publish	VBN
cord-015021-pol2qm74	8086	14	in	in	IN
cord-015021-pol2qm74	8086	15	the	the	DT
cord-015021-pol2qm74	8086	16	six	six	CD
cord-015021-pol2qm74	8086	17	month	month	NN
cord-015021-pol2qm74	8086	18	antibiogram	antibiogram	NNP
cord-015021-pol2qm74	8086	19	which	which	WDT
cord-015021-pol2qm74	8086	20	also	also	RB
cord-015021-pol2qm74	8086	21	includes	include	VBZ
cord-015021-pol2qm74	8086	22	recent	recent	JJ
cord-015021-pol2qm74	8086	23	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	8086	24	sensitivities	sensitivity	NNS
cord-015021-pol2qm74	8086	25	.	.	.
cord-015021-pol2qm74	8087	1	This	this	DT
cord-015021-pol2qm74	8087	2	aids	aid	VBZ
cord-015021-pol2qm74	8087	3	in	in	IN
cord-015021-pol2qm74	8087	4	empiric	empiric	JJ
cord-015021-pol2qm74	8087	5	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	8087	6	selection	selection	NN
cord-015021-pol2qm74	8087	7	against	against	IN
cord-015021-pol2qm74	8087	8	such	such	JJ
cord-015021-pol2qm74	8087	9	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	8087	10	organisms	organism	NNS
cord-015021-pol2qm74	8087	11	.	.	.
cord-015021-pol2qm74	8088	1	In	in	IN
cord-015021-pol2qm74	8088	2	a	a	DT
cord-015021-pol2qm74	8088	3	series	series	NN
cord-015021-pol2qm74	8088	4	of	of	IN
cord-015021-pol2qm74	8088	5	severely	severely	RB
cord-015021-pol2qm74	8088	6	injured	injure	VBN
cord-015021-pol2qm74	8088	7	patients	patient	NNS
cord-015021-pol2qm74	8088	8	(	(	-LRB-
cord-015021-pol2qm74	8088	9	ISS	ISS	NNP
cord-015021-pol2qm74	8088	10	-30	-30	NNP
cord-015021-pol2qm74	8088	11	)	)	-RRB-
cord-015021-pol2qm74	8088	12	,	,	,
cord-015021-pol2qm74	8088	13	mean	mean	JJ
cord-015021-pol2qm74	8088	14	temp	temp	NN
cord-015021-pol2qm74	8088	15	.	.	.
cord-015021-pol2qm74	8089	1	was	be	VBD
cord-015021-pol2qm74	8089	2	101.4F	101.4f	CD
cord-015021-pol2qm74	8090	1	,	,	,
cord-015021-pol2qm74	8090	2	leukocytosis	leukocytosis	NNP
cord-015021-pol2qm74	8090	3	was	be	VBD
cord-015021-pol2qm74	8090	4	16k	16k	CD
cord-015021-pol2qm74	8090	5	,	,	,
cord-015021-pol2qm74	8090	6	Pan2	Pan2	NNP
cord-015021-pol2qm74	8090	7	was	be	VBD
cord-015021-pol2qm74	8090	8	87	87	CD
cord-015021-pol2qm74	8090	9	,	,	,
cord-015021-pol2qm74	8090	10	Fin2	Fin2	NNP
cord-015021-pol2qm74	8090	11	was	be	VBD
cord-015021-pol2qm74	8090	12	.47	.47	CD
cord-015021-pol2qm74	8090	13	,	,	,
cord-015021-pol2qm74	8090	14	and	and	CC
cord-015021-pol2qm74	8090	15	PEEP	PEEP	NNP
cord-015021-pol2qm74	8090	16	was	be	VBD
cord-015021-pol2qm74	8090	17	5.1	5.1	CD
cord-015021-pol2qm74	8090	18	at	at	IN
cord-015021-pol2qm74	8090	19	the	the	DT
cord-015021-pol2qm74	8090	20	time	time	NN
cord-015021-pol2qm74	8090	21	of	of	IN
cord-015021-pol2qm74	8090	22	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8090	23	(	(	-LRB-
cord-015021-pol2qm74	8090	24	ARDS	ARDS	NNP
cord-015021-pol2qm74	8090	25	excluded	exclude	VBD
cord-015021-pol2qm74	8090	26	)	)	-RRB-
cord-015021-pol2qm74	8090	27	.	.	.
cord-015021-pol2qm74	8091	1	There	there	EX
cord-015021-pol2qm74	8091	2	was	be	VBD
cord-015021-pol2qm74	8091	3	marked	mark	VBN
cord-015021-pol2qm74	8091	4	reduction	reduction	NN
cord-015021-pol2qm74	8091	5	in	in	IN
cord-015021-pol2qm74	8091	6	class	class	NN
cord-015021-pol2qm74	8091	7	II	II	NNP
cord-015021-pol2qm74	8091	8	histocompatibility	histocompatibility	NN
cord-015021-pol2qm74	8091	9	antigen	antigen	NN
cord-015021-pol2qm74	8091	10	(	(	-LRB-
cord-015021-pol2qm74	8091	11	HLA	HLA	NNP
cord-015021-pol2qm74	8091	12	-	-	HYPH
cord-015021-pol2qm74	8091	13	DR	DR	NNP
cord-015021-pol2qm74	8091	14	)	)	-RRB-
cord-015021-pol2qm74	8091	15	density	density	NN
cord-015021-pol2qm74	8091	16	on	on	IN
cord-015021-pol2qm74	8091	17	peripheral	peripheral	JJ
cord-015021-pol2qm74	8091	18	and	and	CC
cord-015021-pol2qm74	8091	19	BAL	BAL	NNP
cord-015021-pol2qm74	8091	20	monocyte	monocyte	NNP
cord-015021-pol2qm74	8091	21	/	/	SYM
cord-015021-pol2qm74	8091	22	macrophages	macrophage	NNS
cord-015021-pol2qm74	8091	23	which	which	WDT
cord-015021-pol2qm74	8091	24	recovered	recover	VBD
cord-015021-pol2qm74	8091	25	over	over	IN
cord-015021-pol2qm74	8091	26	time	time	NN
cord-015021-pol2qm74	8091	27	with	with	IN
cord-015021-pol2qm74	8091	28	resolution	resolution	NN
cord-015021-pol2qm74	8091	29	of	of	IN
cord-015021-pol2qm74	8091	30	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8091	31	.	.	.
cord-015021-pol2qm74	8092	1	Immune	immune	JJ
cord-015021-pol2qm74	8092	2	suppression	suppression	NN
cord-015021-pol2qm74	8092	3	occurred	occur	VBD
cord-015021-pol2qm74	8092	4	prior	prior	RB
cord-015021-pol2qm74	8092	5	to	to	IN
cord-015021-pol2qm74	8092	6	development	development	NN
cord-015021-pol2qm74	8092	7	of	of	IN
cord-015021-pol2qm74	8092	8	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8092	9	,	,	,
cord-015021-pol2qm74	8092	10	was	be	VBD
cord-015021-pol2qm74	8092	11	especially	especially	RB
cord-015021-pol2qm74	8092	12	localized	localize	VBN
cord-015021-pol2qm74	8092	13	to	to	IN
cord-015021-pol2qm74	8092	14	the	the	DT
cord-015021-pol2qm74	8092	15	infected	infected	JJ
cord-015021-pol2qm74	8092	16	tissue	tissue	NN
cord-015021-pol2qm74	8092	17	,	,	,
cord-015021-pol2qm74	8092	18	but	but	CC
cord-015021-pol2qm74	8092	19	recovered	recover	VBN
cord-015021-pol2qm74	8092	20	with	with	IN
cord-015021-pol2qm74	8092	21	clinical	clinical	JJ
cord-015021-pol2qm74	8092	22	improvement	improvement	NN
cord-015021-pol2qm74	8092	23	.	.	.
cord-015021-pol2qm74	8093	1	Specific	specific	JJ
cord-015021-pol2qm74	8093	2	immune	immune	JJ
cord-015021-pol2qm74	8093	3	modulation	modulation	NN
cord-015021-pol2qm74	8093	4	targeted	target	VBN
cord-015021-pol2qm74	8093	5	to	to	IN
cord-015021-pol2qm74	8093	6	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	8093	7	white	white	JJ
cord-015021-pol2qm74	8093	8	cells	cell	NNS
cord-015021-pol2qm74	8093	9	may	may	MD
cord-015021-pol2qm74	8093	10	hasten	hasten	VB
cord-015021-pol2qm74	8093	11	clinical	clinical	JJ
cord-015021-pol2qm74	8093	12	recovery	recovery	NN
cord-015021-pol2qm74	8093	13	and	and	CC
cord-015021-pol2qm74	8093	14	minimize	minimize	VB
cord-015021-pol2qm74	8093	15	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	8093	16	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8093	17	.	.	.
cord-015021-pol2qm74	8094	1	-CLINICAL	-CLINICAL	.
cord-015021-pol2qm74	8095	1	EXPERIENCE	EXPERIENCE	NNP
cord-015021-pol2qm74	8095	2	J.	J.	NNP
cord-015021-pol2qm74	8095	3	Tnllemar	Tnllemar	NNP
cord-015021-pol2qm74	8095	4	Amphntericin	Amphntericin	NNP
cord-015021-pol2qm74	8095	5	B	B	NNP
cord-015021-pol2qm74	8095	6	remains	remain	VBZ
cord-015021-pol2qm74	8095	7	the	the	DT
cord-015021-pol2qm74	8095	8	drug	drug	NN
cord-015021-pol2qm74	8095	9	of	of	IN
cord-015021-pol2qm74	8095	10	choice	choice	NN
cord-015021-pol2qm74	8095	11	for	for	IN
cord-015021-pol2qm74	8095	12	many	many	JJ
cord-015021-pol2qm74	8095	13	systemic	systemic	JJ
cord-015021-pol2qm74	8095	14	fungal	fungal	JJ
cord-015021-pol2qm74	8095	15	infections	infection	NNS
cord-015021-pol2qm74	8095	16	.	.	.
cord-015021-pol2qm74	8096	1	Its	-PRON-	PRP$
cord-015021-pol2qm74	8096	2	advantages	advantage	NNS
cord-015021-pol2qm74	8096	3	include	include	VBP
cord-015021-pol2qm74	8096	4	a	a	DT
cord-015021-pol2qm74	8096	5	broad	broad	JJ
cord-015021-pol2qm74	8096	6	spectrum	spectrum	NN
cord-015021-pol2qm74	8096	7	of	of	IN
cord-015021-pol2qm74	8096	8	activity	activity	NN
cord-015021-pol2qm74	8096	9	and	and	CC
cord-015021-pol2qm74	8096	10	intravenous	intravenous	JJ
cord-015021-pol2qm74	8096	11	administration	administration	NN
cord-015021-pol2qm74	8096	12	.	.	.
cord-015021-pol2qm74	8097	1	The	the	DT
cord-015021-pol2qm74	8097	2	major	major	JJ
cord-015021-pol2qm74	8097	3	disadvantages	disadvantage	NNS
cord-015021-pol2qm74	8097	4	of	of	IN
cord-015021-pol2qm74	8097	5	amphoterlcin	amphoterlcin	NNS
cord-015021-pol2qm74	8097	6	B	B	NNP
cord-015021-pol2qm74	8097	7	is	be	VBZ
cord-015021-pol2qm74	8097	8	its	-PRON-	PRP$
cord-015021-pol2qm74	8097	9	severe	severe	JJ
cord-015021-pol2qm74	8097	10	side	side	NN
cord-015021-pol2qm74	8097	11	-	-	HYPH
cord-015021-pol2qm74	8097	12	effects	effect	NNS
cord-015021-pol2qm74	8097	13	,	,	,
cord-015021-pol2qm74	8097	14	especially	especially	RB
cord-015021-pol2qm74	8097	15	the	the	DT
cord-015021-pol2qm74	8097	16	nephrotoxicity	nephrotoxicity	NN
cord-015021-pol2qm74	8097	17	.	.	.
cord-015021-pol2qm74	8098	1	To	to	TO
cord-015021-pol2qm74	8098	2	decrease	decrease	VB
cord-015021-pol2qm74	8098	3	the	the	DT
cord-015021-pol2qm74	8098	4	toxic	toxic	JJ
cord-015021-pol2qm74	8098	5	side	side	NN
cord-015021-pol2qm74	8098	6	..	..	NFP
cord-015021-pol2qm74	8098	7	cffccts	cffcct	VBZ
cord-015021-pol2qm74	8098	8	various	various	JJ
cord-015021-pol2qm74	8098	9	liposomal	liposomal	JJ
cord-015021-pol2qm74	8098	10	amphoteficin	amphoteficin	NNS
cord-015021-pol2qm74	8098	11	B	B	NNP
cord-015021-pol2qm74	8098	12	formulations	formulation	NNS
cord-015021-pol2qm74	8098	13	have	have	VBP
cord-015021-pol2qm74	8098	14	been	be	VBN
cord-015021-pol2qm74	8098	15	produced	produce	VBN
cord-015021-pol2qm74	8098	16	.	.	.
cord-015021-pol2qm74	8099	1	It	-PRON-	PRP
cord-015021-pol2qm74	8099	2	was	be	VBD
cord-015021-pol2qm74	8099	3	found	find	VBN
cord-015021-pol2qm74	8099	4	that	that	IN
cord-015021-pol2qm74	8099	5	these	these	DT
cord-015021-pol2qm74	8099	6	liposemal	liposemal	VBN
cord-015021-pol2qm74	8099	7	formulations	formulation	NNS
cord-015021-pol2qm74	8099	8	were	be	VBD
cord-015021-pol2qm74	8099	9	as	as	RB
cord-015021-pol2qm74	8099	10	effective	effective	JJ
cord-015021-pol2qm74	8099	11	as	as	IN
cord-015021-pol2qm74	8099	12	amphotericin	amphotericin	NNS
cord-015021-pol2qm74	8099	13	B	b	NN
cord-015021-pol2qm74	8099	14	but	but	CC
cord-015021-pol2qm74	8099	15	in	in	IN
cord-015021-pol2qm74	8099	16	contrast	contrast	NN
cord-015021-pol2qm74	8099	17	had	have	VBD
cord-015021-pol2qm74	8099	18	a	a	DT
cord-015021-pol2qm74	8099	19	low	low	JJ
cord-015021-pol2qm74	8099	20	incidence	incidence	NN
cord-015021-pol2qm74	8099	21	of	of	IN
cord-015021-pol2qm74	8099	22	toxicity	toxicity	NN
cord-015021-pol2qm74	8099	23	.	.	.
cord-015021-pol2qm74	8100	1	At	at	IN
cord-015021-pol2qm74	8100	2	present	present	NN
cord-015021-pol2qm74	8100	3	there	there	EX
cord-015021-pol2qm74	8100	4	are	be	VBP
cord-015021-pol2qm74	8100	5	three	three	CD
cord-015021-pol2qm74	8100	6	~different	~different	JJ
cord-015021-pol2qm74	8100	7	variations	variation	NNS
cord-015021-pol2qm74	8100	8	of	of	IN
cord-015021-pol2qm74	8100	9	lipid	lipid	NN
cord-015021-pol2qm74	8100	10	formulations	formulation	NNS
cord-015021-pol2qm74	8100	11	under	under	IN
cord-015021-pol2qm74	8100	12	assessment	assessment	NN
cord-015021-pol2qm74	8100	13	:	:	:
cord-015021-pol2qm74	8100	14	Amphotericin	Amphotericin	NNP
cord-015021-pol2qm74	8100	15	B	B	NNP
cord-015021-pol2qm74	8100	16	lipid	lipid	NN
cord-015021-pol2qm74	8100	17	complex	complex	NN
cord-015021-pol2qm74	8100	18	(	(	-LRB-
cord-015021-pol2qm74	8100	19	ABLC	ABLC	NNP
cord-015021-pol2qm74	8100	20	)	)	-RRB-
cord-015021-pol2qm74	8100	21	,	,	,
cord-015021-pol2qm74	8100	22	amphotericin	amphotericin	NNS
cord-015021-pol2qm74	8100	23	B	b	NN
cord-015021-pol2qm74	8100	24	coloidal	coloidal	NN
cord-015021-pol2qm74	8100	25	dispersion	dispersion	NN
cord-015021-pol2qm74	8100	26	(	(	-LRB-
cord-015021-pol2qm74	8100	27	ABCD	ABCD	NNP
cord-015021-pol2qm74	8100	28	)	)	-RRB-
cord-015021-pol2qm74	8100	29	or	or	CC
cord-015021-pol2qm74	8100	30	true	true	JJ
cord-015021-pol2qm74	8100	31	liposomes	liposome	NNS
cord-015021-pol2qm74	8100	32	.	.	.
cord-015021-pol2qm74	8101	1	The	the	DT
cord-015021-pol2qm74	8101	2	ABLC	ABLC	NNP
cord-015021-pol2qm74	8101	3	has	have	VBZ
cord-015021-pol2qm74	8101	4	a	a	DT
cord-015021-pol2qm74	8101	5	ribbon	ribbon	NN
cord-015021-pol2qm74	8101	6	like	like	IN
cord-015021-pol2qm74	8101	7	structure	structure	NN
cord-015021-pol2qm74	8101	8	.	.	.
cord-015021-pol2qm74	8102	1	It	-PRON-	PRP
cord-015021-pol2qm74	8102	2	has	have	VBZ
cord-015021-pol2qm74	8102	3	been	be	VBN
cord-015021-pol2qm74	8102	4	shown	show	VBN
cord-015021-pol2qm74	8102	5	to	to	TO
cord-015021-pol2qm74	8102	6	have	have	VB
cord-015021-pol2qm74	8102	7	a	a	DT
cord-015021-pol2qm74	8102	8	reduced	reduce	VBN
cord-015021-pol2qm74	8102	9	toxicity	toxicity	NN
cord-015021-pol2qm74	8102	10	and	and	CC
cord-015021-pol2qm74	8102	11	an	an	DT
cord-015021-pol2qm74	8102	12	efficacy	efficacy	NN
cord-015021-pol2qm74	8102	13	ranging	range	VBG
cord-015021-pol2qm74	8102	14	from	from	IN
cord-015021-pol2qm74	8102	15	being	be	VBG
cord-015021-pol2qm74	8102	16	as	as	IN
cord-015021-pol2qm74	8102	17	effective	effective	JJ
cord-015021-pol2qm74	8102	18	to	to	IN
cord-015021-pol2qm74	8102	19	four	four	CD
cord-015021-pol2qm74	8102	20	times	time	NNS
cord-015021-pol2qm74	8102	21	less	less	RBR
cord-015021-pol2qm74	8102	22	effective	effective	JJ
cord-015021-pol2qm74	8102	23	that	that	DT
cord-015021-pol2qm74	8103	1	conventional	conventional	JJ
cord-015021-pol2qm74	8103	2	amphotericin	amphotericin	NNS
cord-015021-pol2qm74	8103	3	B.	B.	NNP
cord-015021-pol2qm74	8104	1	Regarding	regard	VBG
cord-015021-pol2qm74	8104	2	ABCD	ABCD	NNP
cord-015021-pol2qm74	8105	1	the	the	DT
cord-015021-pol2qm74	8105	2	particles	particle	NNS
cord-015021-pol2qm74	8105	3	have	have	VBP
cord-015021-pol2qm74	8105	4	a	a	DT
cord-015021-pol2qm74	8105	5	disk	disk	NN
cord-015021-pol2qm74	8105	6	-	-	HYPH
cord-015021-pol2qm74	8105	7	like	like	JJ
cord-015021-pol2qm74	8105	8	structure	structure	NN
cord-015021-pol2qm74	8105	9	with	with	IN
cord-015021-pol2qm74	8105	10	a	a	DT
cord-015021-pol2qm74	8105	11	diameter	diameter	NN
cord-015021-pol2qm74	8105	12	of	of	IN
cord-015021-pol2qm74	8105	13	around	around	RB
cord-015021-pol2qm74	8105	14	t00	t00	NN
cord-015021-pol2qm74	8105	15	am	be	VBP
cord-015021-pol2qm74	8105	16	and	and	CC
cord-015021-pol2qm74	8105	17	a	a	DT
cord-015021-pol2qm74	8105	18	thickness	thickness	NN
cord-015021-pol2qm74	8105	19	of	of	IN
cord-015021-pol2qm74	8105	20	4	4	CD
cord-015021-pol2qm74	8105	21	nm	nm	NN
cord-015021-pol2qm74	8105	22	.	.	.
cord-015021-pol2qm74	8106	1	The	the	DT
cord-015021-pol2qm74	8106	2	ami	ami	NNP
cord-015021-pol2qm74	8106	3	-	-	HYPH
cord-015021-pol2qm74	8106	4	fungal	fungal	JJ
cord-015021-pol2qm74	8106	5	efficacy	efficacy	NN
cord-015021-pol2qm74	8106	6	is	be	VBZ
cord-015021-pol2qm74	8106	7	2	2	CD
cord-015021-pol2qm74	8106	8	-	-	SYM
cord-015021-pol2qm74	8106	9	4	4	CD
cord-015021-pol2qm74	8106	10	times	time	NNS
cord-015021-pol2qm74	8106	11	less	less	JJR
cord-015021-pol2qm74	8106	12	than	than	IN
cord-015021-pol2qm74	8106	13	that	that	DT
cord-015021-pol2qm74	8106	14	of	of	IN
cord-015021-pol2qm74	8106	15	conventional	conventional	JJ
cord-015021-pol2qm74	8106	16	amphotedcin	amphotedcin	NNS
cord-015021-pol2qm74	8106	17	B.	B.	NNP
cord-015021-pol2qm74	8107	1	Both	both	DT
cord-015021-pol2qm74	8107	2	ABLC	ABLC	NNP
cord-015021-pol2qm74	8107	3	and	and	CC
cord-015021-pol2qm74	8107	4	ABCD	ABCD	NNP
cord-015021-pol2qm74	8107	5	are	be	VBP
cord-015021-pol2qm74	8107	6	presently	presently	RB
cord-015021-pol2qm74	8107	7	investigated	investigate	VBN
cord-015021-pol2qm74	8107	8	in	in	IN
cord-015021-pol2qm74	8107	9	phase	phase	NN
cord-015021-pol2qm74	8107	10	II	II	NNP
cord-015021-pol2qm74	8107	11	/	/	SYM
cord-015021-pol2qm74	8107	12	III	iii	CD
cord-015021-pol2qm74	8107	13	studies	study	NNS
cord-015021-pol2qm74	8107	14	in	in	IN
cord-015021-pol2qm74	8107	15	the	the	DT
cord-015021-pol2qm74	8107	16	US	US	NNP
cord-015021-pol2qm74	8107	17	.	.	.
cord-015021-pol2qm74	8108	1	AmBiseme	AmBiseme	NNP
cord-015021-pol2qm74	8108	2	is	be	VBZ
cord-015021-pol2qm74	8108	3	currently	currently	RB
cord-015021-pol2qm74	8108	4	the	the	DT
cord-015021-pol2qm74	8108	5	only	only	JJ
cord-015021-pol2qm74	8108	6	commefieally	commefieally	RB
cord-015021-pol2qm74	8108	7	available	available	JJ
cord-015021-pol2qm74	8108	8	true	true	JJ
cord-015021-pol2qm74	8108	9	lipesome	lipesome	NNP
cord-015021-pol2qm74	8108	10	.	.	.
cord-015021-pol2qm74	8109	1	AmBiseme	AmBiseme	NNP
cord-015021-pol2qm74	8109	2	is	be	VBZ
cord-015021-pol2qm74	8109	3	a	a	DT
cord-015021-pol2qm74	8109	4	spherical	spherical	JJ
cord-015021-pol2qm74	8109	5	small	small	JJ
cord-015021-pol2qm74	8109	6	unilamellar	unilamellar	NNP
cord-015021-pol2qm74	8109	7	lipesome	lipesome	NNP
cord-015021-pol2qm74	8109	8	with	with	IN
cord-015021-pol2qm74	8109	9	a	a	DT
cord-015021-pol2qm74	8109	10	diameter	diameter	NN
cord-015021-pol2qm74	8109	11	less	less	JJR
cord-015021-pol2qm74	8109	12	than	than	IN
cord-015021-pol2qm74	8109	13	100	100	CD
cord-015021-pol2qm74	8109	14	nm	nm	NN
cord-015021-pol2qm74	8109	15	with	with	IN
cord-015021-pol2qm74	8109	16	a	a	DT
cord-015021-pol2qm74	8109	17	mutina	mutina	JJ
cord-015021-pol2qm74	8109	18	LD50	ld50	NN
cord-015021-pol2qm74	8109	19	of	of	IN
cord-015021-pol2qm74	8109	20	>	>	$
cord-015021-pol2qm74	8109	21	175	175	CD
cord-015021-pol2qm74	8109	22	mg	mg	NNP
cord-015021-pol2qm74	8109	23	/	/	SYM
cord-015021-pol2qm74	8109	24	kg	kg	NN
cord-015021-pol2qm74	8109	25	.	.	.
cord-015021-pol2qm74	8110	1	It	-PRON-	PRP
cord-015021-pol2qm74	8110	2	has	have	VBZ
cord-015021-pol2qm74	8110	3	been	be	VBN
cord-015021-pol2qm74	8110	4	used	use	VBN
cord-015021-pol2qm74	8110	5	in	in	IN
cord-015021-pol2qm74	8110	6	dosages	dosage	NNS
cord-015021-pol2qm74	8110	7	up	up	IN
cord-015021-pol2qm74	8110	8	to	to	TO
cord-015021-pol2qm74	8110	9	6	6	CD
cord-015021-pol2qm74	8110	10	mg	mg	NN
cord-015021-pol2qm74	8110	11	/	/	SYM
cord-015021-pol2qm74	8110	12	kg	kg	NNP
cord-015021-pol2qm74	8110	13	/	/	SYM
cord-015021-pol2qm74	8110	14	day	day	NN
cord-015021-pol2qm74	8110	15	in	in	IN
cord-015021-pol2qm74	8110	16	compassionate	compassionate	JJ
cord-015021-pol2qm74	8110	17	based	base	VBN
cord-015021-pol2qm74	8110	18	studies	study	NNS
cord-015021-pol2qm74	8110	19	with	with	IN
cord-015021-pol2qm74	8110	20	good	good	JJ
cord-015021-pol2qm74	8110	21	tolerability	tolerability	NN
cord-015021-pol2qm74	8110	22	.	.	.
cord-015021-pol2qm74	8111	1	The	the	DT
cord-015021-pol2qm74	8111	2	mycological	mycological	JJ
cord-015021-pol2qm74	8111	3	efficacy	efficacy	NN
cord-015021-pol2qm74	8111	4	range	range	NN
cord-015021-pol2qm74	8111	5	from	from	IN
cord-015021-pol2qm74	8111	6	a	a	DT
cord-015021-pol2qm74	8111	7	83	83	CD
cord-015021-pol2qm74	8111	8	%	%	NN
cord-015021-pol2qm74	8111	9	response	response	NN
cord-015021-pol2qm74	8111	10	rate	rate	NN
cord-015021-pol2qm74	8111	11	for	for	IN
cord-015021-pol2qm74	8111	12	invasive	invasive	JJ
cord-015021-pol2qm74	8111	13	Candida	Candida	NNP
cord-015021-pol2qm74	8111	14	infections	infection	NNS
cord-015021-pol2qm74	8111	15	to	to	IN
cord-015021-pol2qm74	8111	16	41	41	CD
cord-015021-pol2qm74	8111	17	%	%	NN
cord-015021-pol2qm74	8111	18	response	response	NN
cord-015021-pol2qm74	8111	19	rate	rate	NN
cord-015021-pol2qm74	8111	20	for	for	IN
cord-015021-pol2qm74	8111	21	Aspergillosis	Aspergillosis	NNP
cord-015021-pol2qm74	8111	22	.	.	.
cord-015021-pol2qm74	8112	1	AmBisomc	AmBisomc	NNP
cord-015021-pol2qm74	8112	2	have	have	VBP
cord-015021-pol2qm74	8112	3	been	be	VBN
cord-015021-pol2qm74	8112	4	evaluated	evaluate	VBN
cord-015021-pol2qm74	8112	5	as	as	IN
cord-015021-pol2qm74	8112	6	anti	anti	JJ
cord-015021-pol2qm74	8112	7	-	-	JJ
cord-015021-pol2qm74	8112	8	fungal	fungal	JJ
cord-015021-pol2qm74	8112	9	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	8112	10	in	in	IN
cord-015021-pol2qm74	8112	11	randomized	randomized	JJ
cord-015021-pol2qm74	8112	12	trials	trial	NNS
cord-015021-pol2qm74	8112	13	in	in	IN
cord-015021-pol2qm74	8112	14	bone	bone	NN
cord-015021-pol2qm74	8112	15	marrow	marrow	NN
cord-015021-pol2qm74	8112	16	(	(	-LRB-
cord-015021-pol2qm74	8112	17	BMT	BMT	NNP
cord-015021-pol2qm74	8112	18	)	)	-RRB-
cord-015021-pol2qm74	8112	19	and	and	CC
cord-015021-pol2qm74	8112	20	liver	liver	NN
cord-015021-pol2qm74	8112	21	transplant	transplant	NN
cord-015021-pol2qm74	8112	22	(	(	-LRB-
cord-015021-pol2qm74	8112	23	LTX	LTX	NNP
cord-015021-pol2qm74	8112	24	)	)	-RRB-
cord-015021-pol2qm74	8112	25	recipients	recipient	NNS
cord-015021-pol2qm74	8112	26	.	.	.
cord-015021-pol2qm74	8113	1	It	-PRON-	PRP
cord-015021-pol2qm74	8113	2	was	be	VBD
cord-015021-pol2qm74	8113	3	well	well	RB
cord-015021-pol2qm74	8113	4	tolerated	tolerate	VBN
cord-015021-pol2qm74	8113	5	.	.	.
cord-015021-pol2qm74	8114	1	In	in	IN
cord-015021-pol2qm74	8114	2	BMT	BMT	NNP
cord-015021-pol2qm74	8114	3	recipients	recipient	NNS
cord-015021-pol2qm74	8114	4	the	the	DT
cord-015021-pol2qm74	8114	5	incidence	incidence	NN
cord-015021-pol2qm74	8114	6	of	of	IN
cord-015021-pol2qm74	8114	7	proven	prove	VBN
cord-015021-pol2qm74	8114	8	fungal	fungal	JJ
cord-015021-pol2qm74	8114	9	infections	infection	NNS
cord-015021-pol2qm74	8114	10	was	be	VBD
cord-015021-pol2qm74	8114	11	8	8	CD
cord-015021-pol2qm74	8114	12	%	%	NN
cord-015021-pol2qm74	8114	13	among	among	IN
cord-015021-pol2qm74	8114	14	placebo	placebo	NN
cord-015021-pol2qm74	8114	15	treated	treat	VBN
cord-015021-pol2qm74	8114	16	patients	patient	NNS
cord-015021-pol2qm74	8114	17	compared	compare	VBN
cord-015021-pol2qm74	8114	18	to	to	IN
cord-015021-pol2qm74	8114	19	3	3	CD
cord-015021-pol2qm74	8114	20	%	%	NN
cord-015021-pol2qm74	8114	21	for	for	IN
cord-015021-pol2qm74	8114	22	the	the	DT
cord-015021-pol2qm74	8114	23	AmBisome	AmBisome	NNP
cord-015021-pol2qm74	8114	24	treated	treat	VBN
cord-015021-pol2qm74	8114	25	patients	patient	NNS
cord-015021-pol2qm74	8114	26	(	(	-LRB-
cord-015021-pol2qm74	8114	27	ns	ns	IN
cord-015021-pol2qm74	8114	28	)	)	-RRB-
cord-015021-pol2qm74	8114	29	.	.	.
cord-015021-pol2qm74	8115	1	In	in	IN
cord-015021-pol2qm74	8115	2	LTX	LTX	NNP
cord-015021-pol2qm74	8115	3	recipients	recipient	NNS
cord-015021-pol2qm74	8115	4	AmBisome	AmBisome	NNP
cord-015021-pol2qm74	8115	5	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	8115	6	was	be	VBD
cord-015021-pol2qm74	8115	7	effective	effective	JJ
cord-015021-pol2qm74	8115	8	,	,	,
cord-015021-pol2qm74	8115	9	significantly	significantly	RB
cord-015021-pol2qm74	8115	10	reducing	reduce	VBG
cord-015021-pol2qm74	8115	11	the	the	DT
cord-015021-pol2qm74	8115	12	incidence	incidence	NN
cord-015021-pol2qm74	8115	13	of	of	IN
cord-015021-pol2qm74	8115	14	deep	deep	JJ
cord-015021-pol2qm74	8115	15	fungal	fungal	JJ
cord-015021-pol2qm74	8115	16	infections	infection	NNS
cord-015021-pol2qm74	8115	17	from	from	IN
cord-015021-pol2qm74	8115	18	16	16	CD
cord-015021-pol2qm74	8115	19	%	%	NN
cord-015021-pol2qm74	8115	20	to	to	IN
cord-015021-pol2qm74	8115	21	0	0	CD
cord-015021-pol2qm74	8115	22	%	%	NN
cord-015021-pol2qm74	8115	23	ill	ill	JJ
cord-015021-pol2qm74	8115	24	placebo	placebo	NN
cord-015021-pol2qm74	8115	25	and	and	CC
cord-015021-pol2qm74	8115	26	AmBisome	ambisome	NN
cord-015021-pol2qm74	8115	27	treated	treat	VBD
cord-015021-pol2qm74	8115	28	patients	patient	NNS
cord-015021-pol2qm74	8115	29	respectively	respectively	RB
cord-015021-pol2qm74	8115	30	(	(	-LRB-
cord-015021-pol2qm74	8115	31	p<0.01	p<0.01	NNP
cord-015021-pol2qm74	8115	32	)	)	-RRB-
cord-015021-pol2qm74	8115	33	.	.	.
cord-015021-pol2qm74	8116	1	Prospective	prospective	JJ
cord-015021-pol2qm74	8116	2	randomized	randomized	JJ
cord-015021-pol2qm74	8116	3	trials	trial	NNS
cord-015021-pol2qm74	8116	4	comparing	compare	VBG
cord-015021-pol2qm74	8116	5	these	these	DT
cord-015021-pol2qm74	8116	6	various	various	JJ
cord-015021-pol2qm74	8116	7	amphotericin	amphotericin	NNS
cord-015021-pol2qm74	8116	8	B	b	NN
cord-015021-pol2qm74	8116	9	preparations	preparation	NNS
cord-015021-pol2qm74	8116	10	with	with	IN
cord-015021-pol2qm74	8116	11	conventional	conventional	JJ
cord-015021-pol2qm74	8116	12	amphotericin	amphotericin	NNS
cord-015021-pol2qm74	8116	13	B	B	NNP
cord-015021-pol2qm74	8116	14	is	be	VBZ
cord-015021-pol2qm74	8116	15	needed	need	VBN
cord-015021-pol2qm74	8116	16	to	to	TO
cord-015021-pol2qm74	8116	17	determine	determine	VB
cord-015021-pol2qm74	8116	18	their	-PRON-	PRP$
cord-015021-pol2qm74	8116	19	future	future	JJ
cord-015021-pol2qm74	8116	20	place	place	NN
cord-015021-pol2qm74	8116	21	in	in	IN
cord-015021-pol2qm74	8116	22	the	the	DT
cord-015021-pol2qm74	8116	23	therapeutical	therapeutical	JJ
cord-015021-pol2qm74	8116	24	arsenal	arsenal	NN
cord-015021-pol2qm74	8116	25	.	.	.
cord-015021-pol2qm74	8117	1	Two	two	CD
cord-015021-pol2qm74	8117	2	patlentgroups	patlentgroup	NNS
cord-015021-pol2qm74	8117	3	ere	ere	VBP
cord-015021-pol2qm74	8117	4	particularly	particularly	RB
cord-015021-pol2qm74	8117	5	at	at	IN
cord-015021-pol2qm74	8117	6	risk	risk	NN
cord-015021-pol2qm74	8117	7	to	to	TO
cord-015021-pol2qm74	8117	8	develop	develop	VB
cord-015021-pol2qm74	8117	9	serious	serious	JJ
cord-015021-pol2qm74	8117	10	CMV	CMV	NNP
cord-015021-pol2qm74	8117	11	disease	disease	NN
cord-015021-pol2qm74	8117	12	:	:	:
cord-015021-pol2qm74	8118	1	CMV	CMV	NNP
cord-015021-pol2qm74	8118	2	seronegative	seronegative	JJ
cord-015021-pol2qm74	8118	3	transplant	transplant	NN
cord-015021-pol2qm74	8118	4	recipients	recipient	NNS
cord-015021-pol2qm74	8118	5	of	of	IN
cord-015021-pol2qm74	8118	6	seroposltlva	seroposltlva	JJ
cord-015021-pol2qm74	8118	7	donors	donor	NNS
cord-015021-pol2qm74	8118	8	and	and	CC
cord-015021-pol2qm74	8118	9	those	those	DT
cord-015021-pol2qm74	8118	10	patlants	patlant	NNS
cord-015021-pol2qm74	8118	11	treated	treat	VBN
cord-015021-pol2qm74	8118	12	for	for	IN
cord-015021-pol2qm74	8118	13	rejection	rejection	NN
cord-015021-pol2qm74	8118	14	with	with	IN
cord-015021-pol2qm74	8118	15	anti	anti	NNP
cord-015021-pol2qm74	8118	16	T	T	NNP
cord-015021-pol2qm74	8118	17	-	-	HYPH
cord-015021-pol2qm74	8118	18	ceil	ceil	NN
cord-015021-pol2qm74	8118	19	preparations	preparation	NNS
cord-015021-pol2qm74	8118	20	,	,	,
cord-015021-pol2qm74	8118	21	We	-PRON-	PRP
cord-015021-pol2qm74	8118	22	have	have	VBP
cord-015021-pol2qm74	8118	23	evaluated	evaluate	VBN
cord-015021-pol2qm74	8118	24	the	the	DT
cord-015021-pol2qm74	8118	25	value	value	NN
cord-015021-pol2qm74	8118	26	of	of	IN
cord-015021-pol2qm74	8118	27	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	8118	28	anti	anti	JJ
cord-015021-pol2qm74	8118	29	-	-	JJ
cord-015021-pol2qm74	8118	30	CMV	CMV	NNP
cord-015021-pol2qm74	8118	31	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	8118	32	(	(	-LRB-
cord-015021-pol2qm74	8118	33	Cytotect	Cytotect	NNP
cord-015021-pol2qm74	8118	34	"	"	''
cord-015021-pol2qm74	8118	35	,	,	,
cord-015021-pol2qm74	8118	36	Biotest	Biotest	NNP
cord-015021-pol2qm74	8118	37	Pbarma	Pbarma	NNP
cord-015021-pol2qm74	8118	38	GmbH	GmbH	NNP
cord-015021-pol2qm74	8118	39	,	,	,
cord-015021-pol2qm74	8118	40	Dreieich	Dreieich	NNP
cord-015021-pol2qm74	8118	41	,	,	,
cord-015021-pol2qm74	8118	42	FRG	FRG	NNP
cord-015021-pol2qm74	8118	43	)	)	-RRB-
cord-015021-pol2qm74	8118	44	administration	administration	NN
cord-015021-pol2qm74	8118	45	in	in	IN
cord-015021-pol2qm74	8118	46	high	high	JJ
cord-015021-pol2qm74	8118	47	risk	risk	NN
cord-015021-pol2qm74	8118	48	heart	heart	NN
cord-015021-pol2qm74	8118	49	and	and	CC
cord-015021-pol2qm74	8118	50	kidney	kidney	NN
cord-015021-pol2qm74	8118	51	transplant	transplant	NN
cord-015021-pol2qm74	8118	52	recipients	recipient	NNS
cord-015021-pol2qm74	8118	53	,	,	,
cord-015021-pol2qm74	8118	54	In	in	IN
cord-015021-pol2qm74	8118	55	a	a	DT
cord-015021-pol2qm74	8118	56	double	double	JJ
cord-015021-pol2qm74	8118	57	blind	blind	JJ
cord-015021-pol2qm74	8118	58	placebo	placebo	NN
cord-015021-pol2qm74	8118	59	Controlled	Controlled	NNP
cord-015021-pol2qm74	8118	60	study	study	NN
cord-015021-pol2qm74	8118	61	40	40	CD
cord-015021-pol2qm74	8118	62	kidney	kidney	NN
cord-015021-pol2qm74	8118	63	transplant	transplant	NN
cord-015021-pol2qm74	8118	64	recipients	recipient	NNS
cord-015021-pol2qm74	8118	65	,	,	,
cord-015021-pol2qm74	8118	66	treated	treat	VBN
cord-015021-pol2qm74	8118	67	for	for	IN
cord-015021-pol2qm74	8118	68	biopsy	biopsy	NN
cord-015021-pol2qm74	8118	69	proved	prove	VBD
cord-015021-pol2qm74	8118	70	re)action	re)action	NN
cord-015021-pol2qm74	8118	71	with	with	IN
cord-015021-pol2qm74	8118	72	rabbit	rabbit	NN
cord-015021-pol2qm74	8118	73	ATG	ATG	NNP
cord-015021-pol2qm74	8118	74	,	,	,
cord-015021-pol2qm74	8118	75	received	receive	VBD
cord-015021-pol2qm74	8118	76	globullntplacebo	globullntplacebo	NNP
cord-015021-pol2qm74	8118	77	Infusions	infusion	NNS
cord-015021-pol2qm74	8118	78	.	.	.
cord-015021-pol2qm74	8119	1	The	the	DT
cord-015021-pol2qm74	8119	2	preparatlons	preparatlon	NNS
cord-015021-pol2qm74	8119	3	were	be	VBD
cord-015021-pol2qm74	8119	4	given	give	VBN
cord-015021-pol2qm74	8119	5	I	-PRON-	PRP
cord-015021-pol2qm74	8119	6	,	,	,
cord-015021-pol2qm74	8119	7	v	v	NN
cord-015021-pol2qm74	8119	8	,	,	,
cord-015021-pol2qm74	8119	9	In	in	IN
cord-015021-pol2qm74	8119	10	a	a	DT
cord-015021-pol2qm74	8119	11	dose	dose	NN
cord-015021-pol2qm74	8119	12	of	of	IN
cord-015021-pol2qm74	8119	13	100	100	CD
cord-015021-pol2qm74	8119	14	mg	mg	NNP
cord-015021-pol2qm74	8119	15	/	/	SYM
cord-015021-pol2qm74	8119	16	kg	kg	NNP
cord-015021-pol2qm74	8119	17	at	at	IN
cord-015021-pol2qm74	8119	18	day	day	NN
cord-015021-pol2qm74	8119	19	0,7,14,35,56	0,7,14,35,56	NN
cord-015021-pol2qm74	8119	20	and	and	CC
cord-015021-pol2qm74	8119	21	77	77	CD
cord-015021-pol2qm74	8119	22	after	after	IN
cord-015021-pol2qm74	8119	23	the	the	DT
cord-015021-pol2qm74	8119	24	Initiation	Initiation	NNP
cord-015021-pol2qm74	8119	25	of	of	IN
cord-015021-pol2qm74	8119	26	anti	anti	JJ
cord-015021-pol2qm74	8119	27	=	=	NN
cord-015021-pol2qm74	8119	28	rejection	rejection	NN
cord-015021-pol2qm74	8119	29	therapy	therapy	NN
cord-015021-pol2qm74	8119	30	,	,	,
cord-015021-pol2qm74	8119	31	Passive	passive	JJ
cord-015021-pol2qm74	8119	32	immunization	immunization	NN
cord-015021-pol2qm74	8119	33	completely	completely	RB
cord-015021-pol2qm74	8119	34	prevented	prevent	VBD
cord-015021-pol2qm74	8119	35	CMV	CMV	NNP
cord-015021-pol2qm74	8119	36	related	relate	VBN
cord-015021-pol2qm74	8119	37	death	death	NN
cord-015021-pol2qm74	8119	38	,	,	,
cord-015021-pol2qm74	8119	39	although	although	IN
cord-015021-pol2qm74	8119	40	it	-PRON-	PRP
cord-015021-pol2qm74	8119	41	did	do	VBD
cord-015021-pol2qm74	8119	42	not	not	RB
cord-015021-pol2qm74	8119	43	reduce	reduce	VB
cord-015021-pol2qm74	8119	44	th~	th~	NN
cord-015021-pol2qm74	8119	45	incidence	incidence	NN
cord-015021-pol2qm74	8119	46	of	of	IN
cord-015021-pol2qm74	8119	47	CMV	CMV	NNP
cord-015021-pol2qm74	8119	48	isolation	isolation	NN
cord-015021-pol2qm74	8119	49	,	,	,
cord-015021-pol2qm74	8119	50	viraemia	viraemia	NN
cord-015021-pol2qm74	8119	51	or	or	CC
cord-015021-pol2qm74	8119	52	disease	disease	NN
cord-015021-pol2qm74	8119	53	,	,	,
cord-015021-pol2qm74	8119	54	This	this	DT
cord-015021-pol2qm74	8119	55	effect	effect	NN
cord-015021-pol2qm74	8119	56	was	be	VBD
cord-015021-pol2qm74	8119	57	mainly	mainly	RB
cord-015021-pol2qm74	8119	58	observed	observe	VBN
cord-015021-pol2qm74	8119	59	in	in	IN
cord-015021-pol2qm74	8119	60	CMV	CMV	NNP
cord-015021-pol2qm74	8119	61	saronegativa	saronegativa	NN
cord-015021-pol2qm74	8119	62	recipients	recipient	NNS
cord-015021-pol2qm74	8119	63	of	of	IN
cord-015021-pol2qm74	8119	64	a	a	DT
cord-015021-pol2qm74	8119	65	serop0sitive	serop0sitive	NNP
cord-015021-pol2qm74	8119	66	donorktdney	donorktdney	NN
cord-015021-pol2qm74	8119	67	.	.	.
cord-015021-pol2qm74	8120	1	Seroposltive	seroposltive	JJ
cord-015021-pol2qm74	8120	2	recipients	recipient	NNS
cord-015021-pol2qm74	8120	3	did	do	VBD
cord-015021-pol2qm74	8120	4	not	not	RB
cord-015021-pol2qm74	8120	5	benefit	benefit	VB
cord-015021-pol2qm74	8120	6	from	from	IN
cord-015021-pol2qm74	8120	7	treatment	treatment	NN
cord-015021-pol2qm74	8120	8	and	and	CC
cord-015021-pol2qm74	8120	9	seronegatlve	seronegatlve	NN
cord-015021-pol2qm74	8120	10	recipients	recipient	NNS
cord-015021-pol2qm74	8120	11	of	of	IN
cord-015021-pol2qm74	8120	12	a	a	DT
cord-015021-pol2qm74	8120	13	seronegetlye	seronegetlye	JJ
cord-015021-pol2qm74	8120	14	donor	donor	NN
cord-015021-pol2qm74	8120	15	were	be	VBD
cord-015021-pol2qm74	8120	16	not	not	RB
cord-015021-pol2qm74	8120	17	et	et	FW
cord-015021-pol2qm74	8120	18	risk	risk	NN
cord-015021-pol2qm74	8120	19	for	for	IN
cord-015021-pol2qm74	8120	20	CMV	CMV	NNP
cord-015021-pol2qm74	8120	21	infection	infection	NN
cord-015021-pol2qm74	8120	22	at	at	IN
cord-015021-pol2qm74	8120	23	e!l	e!l	NNP
cord-015021-pol2qm74	8120	24	.	.	.
cord-015021-pol2qm74	8121	1	In	in	IN
cord-015021-pol2qm74	8121	2	a	a	DT
cord-015021-pol2qm74	8121	3	open	open	JJ
cord-015021-pol2qm74	8121	4	study	study	NN
cord-015021-pol2qm74	8121	5	the	the	DT
cord-015021-pol2qm74	8121	6	incidence	incidence	NN
cord-015021-pol2qm74	8121	7	of	of	IN
cord-015021-pol2qm74	8121	8	CMV	CMV	NNP
cord-015021-pol2qm74	8121	9	Infection	Infection	NNP
cord-015021-pol2qm74	8121	10	and	and	CC
cord-015021-pol2qm74	8121	11	disease	disease	NN
cord-015021-pol2qm74	8121	12	was	be	VBD
cord-015021-pol2qm74	8121	13	evaluated	evaluate	VBN
cord-015021-pol2qm74	8121	14	In	in	IN
cord-015021-pol2qm74	8121	15	143	143	CD
cord-015021-pol2qm74	8121	16	consecutive	consecutive	JJ
cord-015021-pol2qm74	8121	17	I	I	NNP
cord-015021-pol2qm74	8121	18	~	~	CD
cord-015021-pol2qm74	8121	19	eart	eart	NNP
cord-015021-pol2qm74	8121	20	sllograft	sllograft	NNP
cord-015021-pol2qm74	8121	21	recipients	recipient	NNS
cord-015021-pol2qm74	8121	22	.	.	.
cord-015021-pol2qm74	8122	1	Sixty	sixty	CD
cord-015021-pol2qm74	8122	2	-	-	HYPH
cord-015021-pol2qm74	8122	3	five	five	CD
cord-015021-pol2qm74	8122	4	patients	patient	NNS
cord-015021-pol2qm74	8122	5	were	be	VBD
cord-015021-pol2qm74	8122	6	CMV	CMV	NNP
cord-015021-pol2qm74	8122	7	seronagatlve	seronagatlve	NN
cord-015021-pol2qm74	8122	8	and	and	CC
cord-015021-pol2qm74	8123	1	they	-PRON-	PRP
cord-015021-pol2qm74	8123	2	all	all	DT
cord-015021-pol2qm74	8123	3	received	receive	VBD
cord-015021-pol2qm74	8123	4	passive	passive	JJ
cord-015021-pol2qm74	8123	5	immunlzation	immunlzation	NN
cord-015021-pol2qm74	8123	6	according	accord	VBG
cord-015021-pol2qm74	8123	7	to	to	IN
cord-015021-pol2qm74	8123	8	the	the	DT
cord-015021-pol2qm74	8123	9	dosage	dosage	NN
cord-015021-pol2qm74	8123	10	schedule	schedule	NN
cord-015021-pol2qm74	8123	11	used	use	VBN
cord-015021-pol2qm74	8123	12	in	in	IN
cord-015021-pol2qm74	8123	13	the	the	DT
cord-015021-pol2qm74	8123	14	kidney	kidney	NN
cord-015021-pol2qm74	8123	15	patients	patient	NNS
cord-015021-pol2qm74	8123	16	,	,	,
cord-015021-pol2qm74	8123	17	but	but	CC
cord-015021-pol2qm74	8123	18	starting	start	VBG
cord-015021-pol2qm74	8123	19	on	on	IN
cord-015021-pol2qm74	8123	20	the	the	DT
cord-015021-pol2qm74	8123	21	day	day	NN
cord-015021-pol2qm74	8123	22	of	of	IN
cord-015021-pol2qm74	8123	23	transplantation	transplantation	NN
cord-015021-pol2qm74	8123	24	,	,	,
cord-015021-pol2qm74	8123	25	This	this	DT
cord-015021-pol2qm74	8123	26	scheme	scheme	NN
cord-015021-pol2qm74	8123	27	resulted	result	VBD
cord-015021-pol2qm74	8123	28	in	in	IN
cord-015021-pol2qm74	8123	29	median	median	JJ
cord-015021-pol2qm74	8123	30	sntI	snti	JJ
cord-015021-pol2qm74	8123	31	-	-	HYPH
cord-015021-pol2qm74	8123	32	CMV	CMV	NNP
cord-015021-pol2qm74	8123	33	IgG	igg	NN
cord-015021-pol2qm74	8123	34	titers	titer	NNS
cord-015021-pol2qm74	8123	35	of	of	IN
cord-015021-pol2qm74	8123	36	1200	1200	CD
cord-015021-pol2qm74	8123	37	ELISA	ELISA	NNP
cord-015021-pol2qm74	8123	38	units	unit	NNS
cord-015021-pol2qm74	8123	39	during	during	IN
cord-015021-pol2qm74	8123	40	3	3	CD
cord-015021-pol2qm74	8123	41	months	month	NNS
cord-015021-pol2qm74	8123	42	.	.	.
cord-015021-pol2qm74	8124	1	CMV	CMV	NNP
cord-015021-pol2qm74	8124	2	infection	infection	NN
cord-015021-pol2qm74	8124	3	occurred	occur	VBD
cord-015021-pol2qm74	8124	4	in	in	IN
cord-015021-pol2qm74	8124	5	21/65	21/65	CD
cord-015021-pol2qm74	8124	6	~eronegetlve	~eronegetlve	XX
cord-015021-pol2qm74	8124	7	and	and	CC
cord-015021-pol2qm74	8124	8	in	in	IN
cord-015021-pol2qm74	8124	9	40/81	40/81	CD
cord-015021-pol2qm74	8124	10	seropositive	seropositive	JJ
cord-015021-pol2qm74	8124	11	recipients	recipient	NNS
cord-015021-pol2qm74	8124	12	(	(	-LRB-
cord-015021-pol2qm74	8124	13	n	n	NNP
cord-015021-pol2qm74	8124	14	,	,	,
cord-015021-pol2qm74	8124	15	s	s	NNP
cord-015021-pol2qm74	8124	16	,	,	,
cord-015021-pol2qm74	8124	17	)	)	-RRB-
cord-015021-pol2qm74	8124	18	,	,	.
cord-015021-pol2qm74	8125	1	In	in	IN
cord-015021-pol2qm74	8125	2	ssronegetive	ssronegetive	JJ
cord-015021-pol2qm74	8125	3	donor	donor	NN
cord-015021-pol2qm74	8125	4	-	-	HYPH
cord-015021-pol2qm74	8125	5	recipients	recipient	NNS
cord-015021-pol2qm74	8125	6	pairs	pair	NNS
cord-015021-pol2qm74	8125	7	the	the	DT
cord-015021-pol2qm74	8125	8	incidence	incidence	NN
cord-015021-pol2qm74	8125	9	was	be	VBD
cord-015021-pol2qm74	8125	10	significantly	significantly	RB
cord-015021-pol2qm74	8125	11	lower	low	JJR
cord-015021-pol2qm74	8126	1	(	(	-LRB-
cord-015021-pol2qm74	8126	2	3/34	3/34	CD
cord-015021-pol2qm74	8126	3	]	]	-RRB-
cord-015021-pol2qm74	8126	4	,	,	,
cord-015021-pol2qm74	8126	5	The	the	DT
cord-015021-pol2qm74	8126	6	passively	passively	RB
cord-015021-pol2qm74	8126	7	Immunized	immunize	VBN
cord-015021-pol2qm74	8126	8	seronegstive	seronegstive	JJ
cord-015021-pol2qm74	8126	9	recipients	recipient	NNS
cord-015021-pol2qm74	8126	10	of	of	IN
cord-015021-pol2qm74	8126	11	e	e	NNP
cord-015021-pol2qm74	8126	12	seroposltlve	seroposltlve	NNP
cord-015021-pol2qm74	8126	13	donorheart	donorheart	NNP
cord-015021-pol2qm74	8126	14	showed	show	VBD
cord-015021-pol2qm74	8126	15	comparable	comparable	JJ
cord-015021-pol2qm74	8126	16	incidence	incidence	NN
cord-015021-pol2qm74	8126	17	of	of	IN
cord-015021-pol2qm74	8126	18	CMV	CMV	NNP
cord-015021-pol2qm74	8126	19	infection	infection	NN
cord-015021-pol2qm74	8126	20	f18t29	f18t29	NNP
cord-015021-pol2qm74	8126	21	)	)	-RRB-
cord-015021-pol2qm74	8126	22	vs	vs	IN
cord-015021-pol2qm74	8126	23	the	the	DT
cord-015021-pol2qm74	8126	24	seropositive	seropositive	JJ
cord-015021-pol2qm74	8126	25	recipients	recipient	NNS
cord-015021-pol2qm74	8126	26	.	.	.
cord-015021-pol2qm74	8127	1	Primary	primary	JJ
cord-015021-pol2qm74	8127	2	infection	infection	NN
cord-015021-pol2qm74	8127	3	more	more	RBR
cord-015021-pol2qm74	8127	4	often	often	RB
cord-015021-pol2qm74	8127	5	resulted	result	VBN
cord-015021-pol2qm74	8127	6	in	in	IN
cord-015021-pol2qm74	8127	7	disease	disease	NN
cord-015021-pol2qm74	8127	8	than	than	IN
cord-015021-pol2qm74	8127	9	secondary	secondary	JJ
cord-015021-pol2qm74	8127	10	infection	infection	NN
cord-015021-pol2qm74	8127	11	(	(	-LRB-
cord-015021-pol2qm74	8127	12	11121	11121	CD
cord-015021-pol2qm74	8127	13	v8	v8	NNP
cord-015021-pol2qm74	8127	14	10/40	10/40	NNP
cord-015021-pol2qm74	8127	15	)	)	-RRB-
cord-015021-pol2qm74	8127	16	,	,	,
cord-015021-pol2qm74	8127	17	but	but	CC
cord-015021-pol2qm74	8127	18	no	no	DT
cord-015021-pol2qm74	8127	19	difference	difference	NN
cord-015021-pol2qm74	8127	20	in	in	IN
cord-015021-pol2qm74	8127	21	incidence	incidence	NN
cord-015021-pol2qm74	8127	22	of	of	IN
cord-015021-pol2qm74	8127	23	disease	disease	NN
cord-015021-pol2qm74	8127	24	(	(	-LRB-
cord-015021-pol2qm74	8127	25	11165	11165	CD
cord-015021-pol2qm74	8127	26	vs	vs	IN
cord-015021-pol2qm74	8127	27	10/81	10/81	CD
cord-015021-pol2qm74	8127	28	)	)	-RRB-
cord-015021-pol2qm74	8127	29	or	or	CC
cord-015021-pol2qm74	8127	30	severity	severity	NN
cord-015021-pol2qm74	8127	31	in	in	IN
cord-015021-pol2qm74	8127	32	symptoms	symptom	NNS
cord-015021-pol2qm74	8127	33	was	be	VBD
cord-015021-pol2qm74	8127	34	noted	note	VBN
cord-015021-pol2qm74	8127	35	between	between	IN
cord-015021-pol2qm74	8127	36	the	the	DT
cord-015021-pol2qm74	8127	37	Immunoglobulln	Immunoglobulln	NNP
cord-015021-pol2qm74	8127	38	treated	treat	VBD
cord-015021-pol2qm74	8127	39	serone(]ative	serone(]ative	NNP
cord-015021-pol2qm74	8127	40	patients	patient	NNS
cord-015021-pol2qm74	8127	41	and	and	CC
cord-015021-pol2qm74	8127	42	the	the	DT
cord-015021-pol2qm74	8127	43	seropositiva	seropositiva	NNP
cord-015021-pol2qm74	8127	44	recipients	recipient	NNS
cord-015021-pol2qm74	8127	45	.	.	.
cord-015021-pol2qm74	8128	1	Apparently	apparently	RB
cord-015021-pol2qm74	8128	2	passive	passive	JJ
cord-015021-pol2qm74	8128	3	immunization	immunization	NN
cord-015021-pol2qm74	8128	4	induces	induce	VBZ
cord-015021-pol2qm74	8128	5	anti	anti	JJ
cord-015021-pol2qm74	8128	6	-	-	JJ
cord-015021-pol2qm74	8128	7	CMV	CMV	NNP
cord-015021-pol2qm74	8128	8	immunity	immunity	NN
cord-015021-pol2qm74	8128	9	which	which	WDT
cord-015021-pol2qm74	8128	10	crossly	crossly	RB
cord-015021-pol2qm74	8128	11	resembles	resemble	VBZ
cord-015021-pol2qm74	8128	12	naturally	naturally	RB
cord-015021-pol2qm74	8128	13	acquired	acquire	VBN
cord-015021-pol2qm74	8128	14	resistance	resistance	NN
cord-015021-pol2qm74	8128	15	.	.	.
cord-015021-pol2qm74	8129	1	Abdulkadirov	Abdulkadirov	NNP
cord-015021-pol2qm74	8129	2	K.,Chebotkevich	K.,Chebotkevich	NNP
cord-015021-pol2qm74	8129	3	V.	V.	NNP
cord-015021-pol2qm74	8129	4	,	,	,
cord-015021-pol2qm74	8129	5	Moiseev	Moiseev	NNP
cord-015021-pol2qm74	8129	6	S.	S.	NNP
cord-015021-pol2qm74	8130	1	The	the	DT
cord-015021-pol2qm74	8130	2	incidence	incidence	NN
cord-015021-pol2qm74	8130	3	of	of	IN
cord-015021-pol2qm74	8130	4	infection	infection	NN
cord-015021-pol2qm74	8130	5	is	be	VBZ
cord-015021-pol2qm74	8130	6	still	still	RB
cord-015021-pol2qm74	8130	7	high	high	JJ
cord-015021-pol2qm74	8130	8	in	in	IN
cord-015021-pol2qm74	8130	9	patients	patient	NNS
cord-015021-pol2qm74	8130	10	underwent	undergo	VBD
cord-015021-pol2qm74	8130	11	BMT	BMT	NNP
cord-015021-pol2qm74	8130	12	.	.	.
cord-015021-pol2qm74	8131	1	This	this	DT
cord-015021-pol2qm74	8131	2	complication	complication	NN
cord-015021-pol2qm74	8131	3	is	be	VBZ
cord-015021-pol2qm74	8131	4	the	the	DT
cord-015021-pol2qm74	8131	5	major	major	JJ
cord-015021-pol2qm74	8131	6	cause	cause	NN
cord-015021-pol2qm74	8131	7	of	of	IN
cord-015021-pol2qm74	8131	8	mortality	mortality	NN
cord-015021-pol2qm74	8131	9	if	if	IN
cord-015021-pol2qm74	8131	10	it	-PRON-	PRP
cord-015021-pol2qm74	8131	11	is	be	VBZ
cord-015021-pol2qm74	8131	12	not	not	RB
cord-015021-pol2qm74	8131	13	recognized	recognize	VBN
cord-015021-pol2qm74	8131	14	and	and	CC
cord-015021-pol2qm74	8131	15	treated	treat	VBN
cord-015021-pol2qm74	8131	16	promptly	promptly	RB
cord-015021-pol2qm74	8131	17	and	and	CC
cord-015021-pol2qm74	8131	18	properly	properly	RB
cord-015021-pol2qm74	8131	19	.	.	.
cord-015021-pol2qm74	8132	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8132	2	data	datum	NNS
cord-015021-pol2qm74	8132	3	showed	show	VBD
cord-015021-pol2qm74	8132	4	that	that	IN
cord-015021-pol2qm74	8132	5	from	from	IN
cord-015021-pol2qm74	8132	6	21	21	CD
cord-015021-pol2qm74	8132	7	patients	patient	NNS
cord-015021-pol2qm74	8132	8	with	with	IN
cord-015021-pol2qm74	8132	9	different	different	JJ
cord-015021-pol2qm74	8132	10	types	type	NNS
cord-015021-pol2qm74	8132	11	of	of	IN
cord-015021-pol2qm74	8132	12	leucemia	leucemia	NN
cord-015021-pol2qm74	8132	13	after	after	IN
cord-015021-pol2qm74	8132	14	autologous	autologous	JJ
cord-015021-pol2qm74	8132	15	and	and	CC
cord-015021-pol2qm74	8132	16	allogenzc	allogenzc	VBD
cord-015021-pol2qm74	8132	17	BMT	BMT	NNP
cord-015021-pol2qm74	8132	18	19	19	CD
cord-015021-pol2qm74	8132	19	had	have	VBD
cord-015021-pol2qm74	8132	20	the	the	DT
cord-015021-pol2qm74	8132	21	episodes	episode	NNS
cord-015021-pol2qm74	8132	22	of	of	IN
cord-015021-pol2qm74	8132	23	fever	fever	NN
cord-015021-pol2qm74	8132	24	.	.	.
cord-015021-pol2qm74	8133	1	In	in	IN
cord-015021-pol2qm74	8133	2	the	the	DT
cord-015021-pol2qm74	8133	3	ma	ma	NNP
cord-015021-pol2qm74	8133	4	i	i	NNP
cord-015021-pol2qm74	8133	5	ority	ority	NN
cord-015021-pol2qm74	8133	6	of	of	IN
cord-015021-pol2qm74	8133	7	these	these	DT
cord-015021-pol2qm74	8133	8	episodes	episode	NNS
cord-015021-pol2qm74	8133	9	the	the	DT
cord-015021-pol2qm74	8133	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	8133	11	etiolog$	etiolog$	NNP
cord-015021-pol2qm74	8133	12	gram	gram	NNP
cord-015021-pol2qm74	8133	13	negative	negative	JJ
cord-015021-pol2qm74	8133	14	bacflli	bacflli	NN
cord-015021-pol2qm74	8133	15	and	and	CC
cord-015021-pol2qm74	8133	16	gram	gram	VB
cord-015021-pol2qm74	8133	17	positive	positive	JJ
cord-015021-pol2qm74	8133	18	cocci	coccus	NNS
cord-015021-pol2qm74	8133	19	)	)	-RRB-
cord-015021-pol2qm74	8133	20	can	can	MD
cord-015021-pol2qm74	8133	21	be	be	VB
cord-015021-pol2qm74	8133	22	proved	prove	VBN
cord-015021-pol2qm74	8133	23	.	.	.
cord-015021-pol2qm74	8134	1	On	on	IN
cord-015021-pol2qm74	8134	2	the	the	DT
cord-015021-pol2qm74	8134	3	other	other	JJ
cord-015021-pol2qm74	8134	4	hand	hand	NN
cord-015021-pol2qm74	8134	5	,	,	,
cord-015021-pol2qm74	8134	6	in	in	IN
cord-015021-pol2qm74	8134	7	62	62	CD
cord-015021-pol2qm74	8134	8	%	%	NN
cord-015021-pol2qm74	8134	9	of	of	IN
cord-015021-pol2qm74	8134	10	the	the	DT
cord-015021-pol2qm74	8134	11	fever	fever	NN
cord-015021-pol2qm74	8134	12	cases	case	NNS
cord-015021-pol2qm74	8134	13	we	-PRON-	PRP
cord-015021-pol2qm74	8134	14	detected	detect	VBD
cord-015021-pol2qm74	8134	15	also	also	RB
cord-015021-pol2qm74	8134	16	viral	viral	JJ
cord-015021-pol2qm74	8134	17	respiratory	respiratory	NN
cord-015021-pol2qm74	8134	18	(	(	-LRB-
cord-015021-pol2qm74	8134	19	corona-	corona-	JJ
cord-015021-pol2qm74	8134	20	,	,	,
cord-015021-pol2qm74	8134	21	adeno-	adeno-	NN
cord-015021-pol2qm74	8134	22	,	,	,
cord-015021-pol2qm74	8134	23	RS	rs	NN
cord-015021-pol2qm74	8134	24	-	-	:
cord-015021-pol2qm74	8134	25	and	and	CC
cord-015021-pol2qm74	8134	26	other	other	JJ
cord-015021-pol2qm74	8134	27	)	)	-RRB-
cord-015021-pol2qm74	8134	28	infection	infection	NN
cord-015021-pol2qm74	8134	29	.	.	.
cord-015021-pol2qm74	8135	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8135	2	previous	previous	JJ
cord-015021-pol2qm74	8135	3	investigations	investigation	NNS
cord-015021-pol2qm74	8135	4	showed	show	VBD
cord-015021-pol2qm74	8135	5	that	that	IN
cord-015021-pol2qm74	8135	6	even	even	RB
cord-015021-pol2qm74	8135	7	in	in	IN
cord-015021-pol2qm74	8135	8	healthy	healthy	JJ
cord-015021-pol2qm74	8135	9	persons	person	NNS
cord-015021-pol2qm74	8135	10	the	the	DT
cord-015021-pol2qm74	8135	11	viral	viral	JJ
cord-015021-pol2qm74	8135	12	infection	infection	NN
cord-015021-pol2qm74	8135	13	has	have	VBZ
cord-015021-pol2qm74	8135	14	influence	influence	NN
cord-015021-pol2qm74	8135	15	on	on	IN
cord-015021-pol2qm74	8135	16	antibacterial	antibacterial	JJ
cord-015021-pol2qm74	8135	17	immunity	immunity	NN
cord-015021-pol2qm74	8135	18	,	,	,
cord-015021-pol2qm74	8135	19	in	in	IN
cord-015021-pol2qm74	8135	20	the	the	DT
cord-015021-pol2qm74	8135	21	cases	case	NNS
cord-015021-pol2qm74	8135	22	of	of	IN
cord-015021-pol2qm74	8135	23	model	model	JJ
cord-015021-pol2qm74	8135	24	experimental	experimental	JJ
cord-015021-pol2qm74	8135	25	reaction	reaction	NN
cord-015021-pol2qm74	8135	26	in	in	IN
cord-015021-pol2qm74	8135	27	volunteers	volunteer	NNS
cord-015021-pol2qm74	8135	28	we	-PRON-	PRP
cord-015021-pol2qm74	8135	29	found	find	VBD
cord-015021-pol2qm74	8135	30	the	the	DT
cord-015021-pol2qm74	8135	31	decrease	decrease	NN
cord-015021-pol2qm74	8135	32	of	of	IN
cord-015021-pol2qm74	8135	33	delayed	delay	VBN
cord-015021-pol2qm74	8135	34	hypersensitivity	hypersensitivity	NN
cord-015021-pol2qm74	8135	35	10	10	CD
cord-015021-pol2qm74	8135	36	-	-	SYM
cord-015021-pol2qm74	8135	37	14	14	CD
cord-015021-pol2qm74	8135	38	days	day	NNS
cord-015021-pol2qm74	8135	39	after	after	IN
cord-015021-pol2qm74	8135	40	intranasal	intranasal	NN
cord-015021-pol2qm74	8135	41	inoculation	inoculation	NN
cord-015021-pol2qm74	8135	42	of	of	IN
cord-015021-pol2qm74	8135	43	influenza	influenza	NN
cord-015021-pol2qm74	8135	44	virus	virus	NN
cord-015021-pol2qm74	8135	45	A	a	NN
cord-015021-pol2qm74	8135	46	(	(	-LRB-
cord-015021-pol2qm74	8135	47	H3N2	H3N2	NNP
cord-015021-pol2qm74	8135	48	-	-	HYPH
cord-015021-pol2qm74	8135	49	3	3	CD
cord-015021-pol2qm74	8135	50	)	)	-RRB-
cord-015021-pol2qm74	8135	51	to	to	IN
cord-015021-pol2qm74	8135	52	bacterial	bacterial	JJ
cord-015021-pol2qm74	8135	53	(	(	-LRB-
cord-015021-pol2qm74	8135	54	Staphylococcal	Staphylococcal	NNP
cord-015021-pol2qm74	8135	55	,	,	,
cord-015021-pol2qm74	8135	56	Streptococcal	Streptococcal	NNP
cord-015021-pol2qm74	8135	57	and	and	CC
cord-015021-pol2qm74	8135	58	Pneumococcal	Pneumococcal	NNP
cord-015021-pol2qm74	8135	59	)	)	-RRB-
cord-015021-pol2qm74	8135	60	and	and	CC
cord-015021-pol2qm74	8135	61	~iycoplasma	~iycoplasma	CD
cord-015021-pol2qm74	8135	62	pneumoniae	pneumoniae	NN
cord-015021-pol2qm74	8135	63	antigens	antigen	NNS
cord-015021-pol2qm74	8135	64	in	in	IN
cord-015021-pol2qm74	8135	65	the	the	DT
cord-015021-pol2qm74	8135	66	leucocyte	leucocyte	NNP
cord-015021-pol2qm74	8135	67	migration	migration	NN
cord-015021-pol2qm74	8135	68	inhibition	inhibition	NN
cord-015021-pol2qm74	8135	69	test	test	NN
cord-015021-pol2qm74	8135	70	.	.	.
cord-015021-pol2qm74	8136	1	These	these	DT
cord-015021-pol2qm74	8136	2	results	result	NNS
cord-015021-pol2qm74	8136	3	showed	show	VBD
cord-015021-pol2qm74	8136	4	that	that	IN
cord-015021-pol2qm74	8136	5	respiratory	respiratory	JJ
cord-015021-pol2qm74	8136	6	viruses	virus	NNS
cord-015021-pol2qm74	8136	7	may	may	MD
cord-015021-pol2qm74	8136	8	be	be	VB
cord-015021-pol2qm74	8136	9	the	the	DT
cord-015021-pol2qm74	8136	10	important	important	JJ
cord-015021-pol2qm74	8136	11	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	8136	12	factor	factor	NN
cord-015021-pol2qm74	8136	13	in	in	IN
cord-015021-pol2qm74	8136	14	the	the	DT
cord-015021-pol2qm74	8136	15	development	development	NN
cord-015021-pol2qm74	8136	16	of	of	IN
cord-015021-pol2qm74	8136	17	bacterial	bacterial	JJ
cord-015021-pol2qm74	8136	18	infection	infection	NN
cord-015021-pol2qm74	8136	19	in	in	IN
cord-015021-pol2qm74	8136	20	posttransplanted	posttransplanted	JJ
cord-015021-pol2qm74	8136	21	period	period	NN
cord-015021-pol2qm74	8136	22	.	.	.
cord-015021-pol2qm74	8137	1	We	-PRON-	PRP
cord-015021-pol2qm74	8137	2	consider	consider	VBP
cord-015021-pol2qm74	8137	3	the	the	DT
cord-015021-pol2qm74	8137	4	constant	constant	JJ
cord-015021-pol2qm74	8137	5	control	control	NN
cord-015021-pol2qm74	8137	6	of	of	IN
cord-015021-pol2qm74	8137	7	latent	latent	JJ
cord-015021-pol2qm74	8137	8	and	and	CC
cord-015021-pol2qm74	8137	9	visual	visual	JJ
cord-015021-pol2qm74	8137	10	respiratory	respiratory	JJ
cord-015021-pol2qm74	8137	11	viral	viral	JJ
cord-015021-pol2qm74	8137	12	infection	infection	NN
cord-015021-pol2qm74	8137	13	in	in	IN
cord-015021-pol2qm74	8137	14	BMT	BMT	NNP
cord-015021-pol2qm74	8137	15	patients	patient	NNS
cord-015021-pol2qm74	8137	16	to	to	TO
cord-015021-pol2qm74	8137	17	be	be	VB
cord-015021-pol2qm74	8137	18	very	very	RB
cord-015021-pol2qm74	8137	19	important	important	JJ
cord-015021-pol2qm74	8137	20	.	.	.
cord-015021-pol2qm74	8138	1	FIccB	FIccB	NNPS
cord-015021-pol2qm74	8139	1	the	the	DT
cord-015021-pol2qm74	8139	2	~ter£~Li	~ter£~Li	NNS
cord-015021-pol2qm74	8139	3	of	of	IN
cord-015021-pol2qm74	8139	4	the	the	DT
cord-015021-pol2qm74	8139	5	Nation~	Nation~	NNP
cord-015021-pol2qm74	8140	1	l	l	NNP
cord-015021-pol2qm74	8140	2	Institute	Institute	NNP
cord-015021-pol2qm74	8140	3	of	of	IN
cord-015021-pol2qm74	8140	4	TraD/~atoloqy	TraD/~atoloqy	NNP
cord-015021-pol2qm74	8140	5	in	in	IN
cord-015021-pol2qm74	8140	6	Budapest	Budapest	NNP
cord-015021-pol2qm74	8141	1	1.00	1.00	CD
cord-015021-pol2qm74	8141	2	consecutive	consecutive	JJ
cord-015021-pol2qm74	8141	3	cases	case	NNS
cord-015021-pol2qm74	8141	4	of	of	IN
cord-015021-pol2qm74	8141	5	revision	revision	NN
cord-015021-pol2qm74	8141	6	hip	hip	NN
cord-015021-pol2qm74	8141	7	grafting	grafting	NN
cord-015021-pol2qm74	8141	8	were	be	VBD
cord-015021-pol2qm74	8141	9	carried	carry	VBN
cord-015021-pol2qm74	8141	10	out	out	RP
cord-015021-pol2qm74	8141	11	arthroplasties	arthroplasties	NNP
cord-015021-pol2qm74	8141	12	wlth	wlth	NNP
cord-015021-pol2qm74	8141	13	hemoloquous	hemoloquous	NNP
cord-015021-pol2qm74	8141	14	bone	bone	NN
cord-015021-pol2qm74	8141	15	between	between	IN
cord-015021-pol2qm74	8141	16	the	the	DT
cord-015021-pol2qm74	8141	17	years	year	NNS
cord-015021-pol2qm74	8141	18	1990	1990	CD
cord-015021-pol2qm74	8141	19	and	and	CC
cord-015021-pol2qm74	8141	20	1993	1993	CD
cord-015021-pol2qm74	8141	21	.	.	.
cord-015021-pol2qm74	8142	1	In	in	IN
cord-015021-pol2qm74	8142	2	the	the	DT
cord-015021-pol2qm74	8142	3	same	same	JJ
cord-015021-pol2qm74	8142	4	period	period	NN
cord-015021-pol2qm74	8142	5	of	of	IN
cord-015021-pol2qm74	8142	6	time	time	NN
cord-015021-pol2qm74	8142	7	732	732	CD
cord-015021-pol2qm74	8142	8	pri~	pri~	CD
cord-015021-pol2qm74	8142	9	total	total	JJ
cord-015021-pol2qm74	8142	10	hlp	hlp	NN
cord-015021-pol2qm74	8142	11	replacen	replacen	NN
cord-015021-pol2qm74	8142	12	~	~	NFP
cord-015021-pol2qm74	8142	13	nts	nts	NNPS
cord-015021-pol2qm74	8142	14	were	be	VBD
cord-015021-pol2qm74	8142	15	performed	perform	VBN
cord-015021-pol2qm74	8142	16	under	under	IN
cord-015021-pol2qm74	8142	17	i4entieal	i4entieal	JJ
cord-015021-pol2qm74	8142	18	technical	technical	JJ
cord-015021-pol2qm74	8142	19	conditions	condition	NNS
cord-015021-pol2qm74	8142	20	.	.	.
cord-015021-pol2qm74	8143	1	The	the	DT
cord-015021-pol2qm74	8143	2	average	average	JJ
cord-015021-pol2qm74	8143	3	septic	septic	JJ
cord-015021-pol2qm74	8143	4	rate	rate	NN
cord-015021-pol2qm74	8143	5	for	for	IN
cord-015021-pol2qm74	8143	6	the	the	DT
cord-015021-pol2qm74	8143	7	'	'	``
cord-015021-pol2qm74	8143	8	total	total	JJ
cord-015021-pol2qm74	8143	9	hip	hip	NN
cord-015021-pol2qm74	8143	10	althroplasties	althroplastie	NNS
cord-015021-pol2qm74	8143	11	was	be	VBD
cord-015021-pol2qm74	8143	12	less	less	JJR
cord-015021-pol2qm74	8143	13	than	than	IN
cord-015021-pol2qm74	8143	14	1	1	CD
cord-015021-pol2qm74	8143	15	%	%	NN
cord-015021-pol2qm74	8143	16	.	.	.
cord-015021-pol2qm74	8144	1	In	in	IN
cord-015021-pol2qm74	8144	2	the	the	DT
cord-015021-pol2qm74	8144	3	selected	select	VBN
cord-015021-pol2qm74	8144	4	i00	i00	NN
cord-015021-pol2qm74	8144	5	cases	case	NNS
cord-015021-pol2qm74	8144	6	the	the	DT
cord-015021-pol2qm74	8144	7	septic	septic	JJ
cord-015021-pol2qm74	8144	8	rate	rate	NN
cord-015021-pol2qm74	8144	9	was	be	VBD
cord-015021-pol2qm74	8144	10	4	4	CD
cord-015021-pol2qm74	8144	11	%	%	NN
cord-015021-pol2qm74	8144	12	indicating	indicate	VBG
cord-015021-pol2qm74	8144	13	the	the	DT
cord-015021-pol2qm74	8144	14	role	role	NN
cord-015021-pol2qm74	8144	15	of	of	IN
cord-015021-pol2qm74	8144	16	bone	bone	NN
cord-015021-pol2qm74	8144	17	grafting	grafting	NN
cord-015021-pol2qm74	8144	18	°	°	NN
cord-015021-pol2qm74	8144	19	Homografts	Homografts	NNP
cord-015021-pol2qm74	8144	20	were	be	VBD
cord-015021-pol2qm74	8144	21	prepared	prepare	VBN
cord-015021-pol2qm74	8144	22	by	by	IN
cord-015021-pol2qm74	8144	23	deep	deep	JJ
cord-015021-pol2qm74	8144	24	freezing~	freezing~	NNP
cord-015021-pol2qm74	8144	25	It	-PRON-	PRP
cord-015021-pol2qm74	8144	26	.is	.is	XX
cord-015021-pol2qm74	8144	27	recognized	recognize	VBD
cord-015021-pol2qm74	8144	28	that	that	IN
cord-015021-pol2qm74	8144	29	the	the	DT
cord-015021-pol2qm74	8144	30	cells	cell	NNS
cord-015021-pol2qm74	8144	31	of	of	IN
cord-015021-pol2qm74	8144	32	the	the	DT
cord-015021-pol2qm74	8144	33	hL	hL	NNP
cord-015021-pol2qm74	8144	34	~	~	NFP
cord-015021-pol2qm74	8144	35	grafts	graft	NNS
cord-015021-pol2qm74	8144	36	become	become	VBP
cord-015021-pol2qm74	8144	37	destroyed	destroy	VBN
cord-015021-pol2qm74	8144	38	by	by	IN
cord-015021-pol2qm74	8144	39	the	the	DT
cord-015021-pol2qm74	8144	40	ium	ium	NN
cord-015021-pol2qm74	8144	41	~	~	NFP
cord-015021-pol2qm74	8144	42	unological	unological	JJ
cord-015021-pol2qm74	8144	43	,	,	,
cord-015021-pol2qm74	8144	44	response	response	NN
cord-015021-pol2qm74	8144	45	of	of	IN
cord-015021-pol2qm74	8144	46	the	the	DT
cord-015021-pol2qm74	8144	47	host~	host~	NNP
cord-015021-pol2qm74	8144	48	and	and	CC
cord-015021-pol2qm74	8144	49	the	the	DT
cord-015021-pol2qm74	8144	50	patients	patient	NNS
cord-015021-pol2qm74	8144	51	develop	develop	VBP
cord-015021-pol2qm74	8144	52	~ti	~ti	NNP
cord-015021-pol2qm74	8144	53	-	-	HYPH
cord-015021-pol2qm74	8144	54	HL~	HL~	NNP
cord-015021-pol2qm74	8144	55	,	,	,
cord-015021-pol2qm74	8144	56	ar	ar	NNP
cord-015021-pol2qm74	8144	57	~	~	NFP
cord-015021-pol2qm74	8144	58	tib'o	tib'o	NNS
cord-015021-pol2qm74	8144	59	~	~	NFP
cord-015021-pol2qm74	8144	60	ies	ie	NNS
cord-015021-pol2qm74	8144	61	.	.	.
cord-015021-pol2qm74	8145	1	The	the	DT
cord-015021-pol2qm74	8145	2	dead	dead	JJ
cord-015021-pol2qm74	8146	1	~trix	~trix	NFP
cord-015021-pol2qm74	8146	2	,	,	,
cord-015021-pol2qm74	8146	3	however	however	RB
cord-015021-pol2qm74	8146	4	,	,	,
cord-015021-pol2qm74	8146	5	has	have	VBZ
cord-015021-pol2qm74	8146	6	a	a	DT
cord-015021-pol2qm74	8146	7	bone	bone	NN
cord-015021-pol2qm74	8146	8	-	-	HYPH
cord-015021-pol2qm74	8146	9	inducing	induce	VBG
cord-015021-pol2qm74	8146	10	capacity	capacity	NN
cord-015021-pol2qm74	8146	11	that	that	WDT
cord-015021-pol2qm74	8146	12	stimulates	stimulate	VBZ
cord-015021-pol2qm74	8146	13	host	host	NN
cord-015021-pol2qm74	8146	14	osteoblasts	osteoblast	NNS
cord-015021-pol2qm74	8146	15	to	to	TO
cord-015021-pol2qm74	8146	16	recolonize	recolonize	VB
cord-015021-pol2qm74	8146	17	the	the	DT
cord-015021-pol2qm74	8146	18	*	*	NFP
cord-015021-pol2qm74	8146	19	I~/trix	I~/trix	NNP
cord-015021-pol2qm74	8146	20	Which	which	WDT
cord-015021-pol2qm74	8146	21	serves	serve	VBZ
cord-015021-pol2qm74	8146	22	as	as	IN
cord-015021-pol2qm74	8146	23	scaffolding	scaffolding	NN
cord-015021-pol2qm74	8146	24	.	.	.
cord-015021-pol2qm74	8147	1	The	the	DT
cord-015021-pol2qm74	8147	2	sequence	sequence	NN
cord-015021-pol2qm74	8147	3	of	of	IN
cord-015021-pol2qm74	8147	4	events	event	NNS
cord-015021-pol2qm74	8147	5	favours	favour	VBZ
cord-015021-pol2qm74	8147	6	the	the	DT
cord-015021-pol2qm74	8147	7	infections	infection	NNS
cord-015021-pol2qm74	8147	8	.	.	.
cord-015021-pol2qm74	8148	1	For	for	IN
cord-015021-pol2qm74	8148	2	this	this	DT
cord-015021-pol2qm74	8148	3	reason	reason	NN
cord-015021-pol2qm74	8148	4	,	,	,
cord-015021-pol2qm74	8148	5	beside	beside	IN
cord-015021-pol2qm74	8148	6	preventive	preventive	JJ
cord-015021-pol2qm74	8148	7	perioperative	perioperative	JJ
cord-015021-pol2qm74	8148	8	systemic	systemic	JJ
cord-015021-pol2qm74	8148	9	ant	ant	JJ
cord-015021-pol2qm74	8148	10	/	/	SYM
cord-015021-pol2qm74	8148	11	biotic	biotic	JJ
cord-015021-pol2qm74	8148	12	treatment	treatment	NN
cord-015021-pol2qm74	8148	13	,	,	,
cord-015021-pol2qm74	8148	14	local	local	JJ
cord-015021-pol2qm74	8148	15	~ntibioties	~ntibioties	NNP
cord-015021-pol2qm74	8148	16	were	be	VBD
cord-015021-pol2qm74	8148	17	also	also	RB
cord-015021-pol2qm74	8148	18	applied	apply	VBN
cord-015021-pol2qm74	8148	19	in	in	IN
cord-015021-pol2qm74	8148	20	the	the	DT
cord-015021-pol2qm74	8148	21	form	form	NN
cord-015021-pol2qm74	8148	22	of	of	IN
cord-015021-pol2qm74	8148	23	antibiotic-//npregnated	antibiotic-//npregnate	VBN
cord-015021-pol2qm74	8148	24	cement	cement	NN
cord-015021-pol2qm74	8148	25	.	.	.
cord-015021-pol2qm74	8149	1	The	the	DT
cord-015021-pol2qm74	8149	2	role	role	NN
cord-015021-pol2qm74	8149	3	of	of	IN
cord-015021-pol2qm74	8149	4	age	age	NN
cord-015021-pol2qm74	8149	5	and	and	CC
cord-015021-pol2qm74	8149	6	the	the	DT
cord-015021-pol2qm74	8149	7	.immune	.immune	NNP
cord-015021-pol2qm74	8149	8	status	status	NN
cord-015021-pol2qm74	8149	9	of	of	IN
cord-015021-pol2qm74	8149	10	the	the	DT
cord-015021-pol2qm74	8149	11	patients	patient	NNS
cord-015021-pol2qm74	8149	12	.is	.is	NNP
cord-015021-pol2qm74	8149	13	discussed	discuss	VBD
cord-015021-pol2qm74	8149	14	..	..	.
cord-015021-pol2qm74	8150	1	The	the	DT
cord-015021-pol2qm74	8150	2	purpose	purpose	NN
cord-015021-pol2qm74	8150	3	of	of	IN
cord-015021-pol2qm74	8150	4	this	this	DT
cord-015021-pol2qm74	8150	5	study	study	NN
cord-015021-pol2qm74	8150	6	is	be	VBZ
cord-015021-pol2qm74	8150	7	to	to	TO
cord-015021-pol2qm74	8150	8	evaluate	evaluate	VB
cord-015021-pol2qm74	8150	9	the	the	DT
cord-015021-pol2qm74	8150	10	rate	rate	NN
cord-015021-pol2qm74	8150	11	of	of	IN
cord-015021-pol2qm74	8150	12	toxemia	toxemia	NN
cord-015021-pol2qm74	8150	13	in	in	IN
cord-015021-pol2qm74	8150	14	patients	patient	NNS
cord-015021-pol2qm74	8150	15	with	with	IN
cord-015021-pol2qm74	8150	16	acute	acute	JJ
cord-015021-pol2qm74	8150	17	panereatitis	panereatitis	NN
cord-015021-pol2qm74	8150	18	and	and	CC
cord-015021-pol2qm74	8150	19	to	to	TO
cord-015021-pol2qm74	8150	20	find	find	VB
cord-015021-pol2qm74	8150	21	this	this	DT
cord-015021-pol2qm74	8150	22	coudition	coudition	NN
cord-015021-pol2qm74	8150	23	to	to	IN
cord-015021-pol2qm74	8150	24	the	the	DT
cord-015021-pol2qm74	8150	25	activation	activation	NN
cord-015021-pol2qm74	8150	26	of	of	IN
cord-015021-pol2qm74	8150	27	cascade	cascade	NN
cord-015021-pol2qm74	8150	28	systems	system	NNS
cord-015021-pol2qm74	8150	29	that	that	WDT
cord-015021-pol2qm74	8150	30	are	be	VBP
cord-015021-pol2qm74	8150	31	encountered	encounter	VBN
cord-015021-pol2qm74	8150	32	in	in	IN
cord-015021-pol2qm74	8150	33	the	the	DT
cord-015021-pol2qm74	8150	34	subsequent	subsequent	JJ
cord-015021-pol2qm74	8150	35	complications	complication	NNS
cord-015021-pol2qm74	8150	36	of	of	IN
cord-015021-pol2qm74	8150	37	the	the	DT
cord-015021-pol2qm74	8150	38	disease	disease	NN
cord-015021-pol2qm74	8150	39	.	.	.
cord-015021-pol2qm74	8151	1	We	-PRON-	PRP
cord-015021-pol2qm74	8151	2	studied	study	VBD
cord-015021-pol2qm74	8151	3	a	a	DT
cord-015021-pol2qm74	8151	4	series	series	NN
cord-015021-pol2qm74	8151	5	of	of	IN
cord-015021-pol2qm74	8151	6	45	45	CD
cord-015021-pol2qm74	8151	7	patients	patient	NNS
cord-015021-pol2qm74	8151	8	with	with	IN
cord-015021-pol2qm74	8151	9	acute	acute	JJ
cord-015021-pol2qm74	8151	10	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8151	11	,	,	,
cord-015021-pol2qm74	8151	12	the	the	DT
cord-015021-pol2qm74	8151	13	severeness	severeness	NN
cord-015021-pol2qm74	8151	14	of	of	IN
cord-015021-pol2qm74	8151	15	which	which	WDT
cord-015021-pol2qm74	8151	16	was	be	VBD
cord-015021-pol2qm74	8151	17	evaluated	evaluate	VBN
cord-015021-pol2qm74	8151	18	by	by	IN
cord-015021-pol2qm74	8151	19	the	the	DT
cord-015021-pol2qm74	8151	20	Ranson	Ranson	NNP
cord-015021-pol2qm74	8151	21	's	's	POS
cord-015021-pol2qm74	8151	22	criteria	criterion	NNS
cord-015021-pol2qm74	8151	23	and	and	CC
cord-015021-pol2qm74	8151	24	the	the	DT
cord-015021-pol2qm74	8151	25	Apach	Apach	NNP
cord-015021-pol2qm74	8151	26	-	-	HYPH
cord-015021-pol2qm74	8151	27	II	II	NNP
cord-015021-pol2qm74	8151	28	scoring	scoring	NN
cord-015021-pol2qm74	8151	29	system	system	NN
cord-015021-pol2qm74	8151	30	.	.	.
cord-015021-pol2qm74	8152	1	All	all	DT
cord-015021-pol2qm74	8152	2	of	of	IN
cord-015021-pol2qm74	8152	3	them	-PRON-	PRP
cord-015021-pol2qm74	8152	4	were	be	VBD
cord-015021-pol2qm74	8152	5	considered	consider	VBN
cord-015021-pol2qm74	8152	6	to	to	TO
cord-015021-pol2qm74	8152	7	have	have	VB
cord-015021-pol2qm74	8152	8	severe	severe	JJ
cord-015021-pol2qm74	8152	9	acute	acute	JJ
cord-015021-pol2qm74	8152	10	puncreatitis	puncreatitis	NN
cord-015021-pol2qm74	8152	11	.	.	.
cord-015021-pol2qm74	8153	1	The	the	DT
cord-015021-pol2qm74	8153	2	determination	determination	NN
cord-015021-pol2qm74	8153	3	of	of	IN
cord-015021-pol2qm74	8153	4	toxemia	toxemia	NN
cord-015021-pol2qm74	8153	5	was	be	VBD
cord-015021-pol2qm74	8153	6	made	make	VBN
cord-015021-pol2qm74	8153	7	using	use	VBG
cord-015021-pol2qm74	8153	8	the	the	DT
cord-015021-pol2qm74	8153	9	Limulus	Limulus	NNP
cord-015021-pol2qm74	8153	10	test	test	NN
cord-015021-pol2qm74	8153	11	(	(	-LRB-
cord-015021-pol2qm74	8153	12	LAL	LAL	NNP
cord-015021-pol2qm74	8153	13	test	test	NN
cord-015021-pol2qm74	8153	14	)	)	-RRB-
cord-015021-pol2qm74	8153	15	.	.	.
cord-015021-pol2qm74	8154	1	We	-PRON-	PRP
cord-015021-pol2qm74	8154	2	also	also	RB
cord-015021-pol2qm74	8154	3	determined	determine	VBD
cord-015021-pol2qm74	8154	4	the	the	DT
cord-015021-pol2qm74	8154	5	levels	level	NNS
cord-015021-pol2qm74	8154	6	of	of	IN
cord-015021-pol2qm74	8154	7	the	the	DT
cord-015021-pol2qm74	8154	8	third	third	JJ
cord-015021-pol2qm74	8154	9	(	(	-LRB-
cord-015021-pol2qm74	8154	10	C3	C3	NNP
cord-015021-pol2qm74	8154	11	)	)	-RRB-
cord-015021-pol2qm74	8154	12	and	and	CC
cord-015021-pol2qm74	8154	13	fourth	fourth	JJ
cord-015021-pol2qm74	8154	14	(	(	-LRB-
cord-015021-pol2qm74	8154	15	C4	C4	NNP
cord-015021-pol2qm74	8154	16	)	)	-RRB-
cord-015021-pol2qm74	8154	17	Complement	complement	JJ
cord-015021-pol2qm74	8154	18	components	component	NNS
cord-015021-pol2qm74	8154	19	as	as	IN
cord-015021-pol2qm74	8154	20	weU	weU	NNP
cord-015021-pol2qm74	8154	21	as	as	IN
cord-015021-pol2qm74	8154	22	the	the	DT
cord-015021-pol2qm74	8154	23	coagulation	coagulation	NN
cord-015021-pol2qm74	8154	24	factors	factor	NNS
cord-015021-pol2qm74	8154	25	,	,	,
cord-015021-pol2qm74	8154	26	Iibrinolysis	Iibrinolysis	NNP
cord-015021-pol2qm74	8154	27	faeters	faeter	NNS
cord-015021-pol2qm74	8154	28	and	and	CC
cord-015021-pol2qm74	8154	29	Kimns	Kimns	NNP
cord-015021-pol2qm74	8154	30	by	by	IN
cord-015021-pol2qm74	8154	31	serial	serial	JJ
cord-015021-pol2qm74	8154	32	measurements	measurement	NNS
cord-015021-pol2qm74	8154	33	.	.	.
cord-015021-pol2qm74	8155	1	The	the	DT
cord-015021-pol2qm74	8155	2	severity	severity	NN
cord-015021-pol2qm74	8155	3	of	of	IN
cord-015021-pol2qm74	8155	4	the	the	DT
cord-015021-pol2qm74	8155	5	disease	disease	NN
cord-015021-pol2qm74	8155	6	was	be	VBD
cord-015021-pol2qm74	8155	7	serially	serially	RB
cord-015021-pol2qm74	8155	8	determined	determine	VBN
cord-015021-pol2qm74	8155	9	by	by	IN
cord-015021-pol2qm74	8155	10	the	the	DT
cord-015021-pol2qm74	8155	11	Apach	Apach	NNP
cord-015021-pol2qm74	8155	12	-	-	HYPH
cord-015021-pol2qm74	8155	13	II	II	NNP
cord-015021-pol2qm74	8155	14	scoring	scoring	NN
cord-015021-pol2qm74	8155	15	system	system	NN
cord-015021-pol2qm74	8155	16	.	.	.
cord-015021-pol2qm74	8156	1	It	-PRON-	PRP
cord-015021-pol2qm74	8156	2	was	be	VBD
cord-015021-pol2qm74	8156	3	found	find	VBN
cord-015021-pol2qm74	8156	4	that	that	IN
cord-015021-pol2qm74	8156	5	Complement	Complement	NNP
cord-015021-pol2qm74	8156	6	activation	activation	NN
cord-015021-pol2qm74	8156	7	(	(	-LRB-
cord-015021-pol2qm74	8156	8	which	which	WDT
cord-015021-pol2qm74	8156	9	was	be	VBD
cord-015021-pol2qm74	8156	10	also	also	RB
cord-015021-pol2qm74	8156	11	assessed	assess	VBN
cord-015021-pol2qm74	8156	12	using	use	VBG
cord-015021-pol2qm74	8156	13	a	a	DT
cord-015021-pol2qm74	8156	14	graphically	graphically	RB
cord-015021-pol2qm74	8156	15	illustrated	illustrate	VBN
cord-015021-pol2qm74	8156	16	method	method	NN
cord-015021-pol2qm74	8156	17	by	by	IN
cord-015021-pol2qm74	8156	18	a	a	DT
cord-015021-pol2qm74	8156	19	aggregometer	aggregometer	NN
cord-015021-pol2qm74	8156	20	)	)	-RRB-
cord-015021-pol2qm74	8156	21	was	be	VBD
cord-015021-pol2qm74	8156	22	followed	follow	VBN
cord-015021-pol2qm74	8156	23	by	by	IN
cord-015021-pol2qm74	8156	24	an	an	DT
cord-015021-pol2qm74	8156	25	increase	increase	NN
cord-015021-pol2qm74	8156	26	of	of	IN
cord-015021-pol2qm74	8156	27	morbitity	morbitity	NN
cord-015021-pol2qm74	8156	28	and	and	CC
cord-015021-pol2qm74	8156	29	mortality	mortality	NN
cord-015021-pol2qm74	8156	30	.We	.We	.
cord-015021-pol2qm74	8157	1	also	also	RB
cord-015021-pol2qm74	8157	2	detected	detect	VBD
cord-015021-pol2qm74	8157	3	that	that	IN
cord-015021-pol2qm74	8157	4	toxemia	toxemia	NN
cord-015021-pol2qm74	8157	5	(	(	-LRB-
cord-015021-pol2qm74	8157	6	positive	positive	JJ
cord-015021-pol2qm74	8157	7	LAL	LAL	NNP
cord-015021-pol2qm74	8157	8	-	-	HYPH
cord-015021-pol2qm74	8157	9	test	test	NN
cord-015021-pol2qm74	8157	10	)	)	-RRB-
cord-015021-pol2qm74	8157	11	was	be	VBD
cord-015021-pol2qm74	8157	12	closely	closely	RB
cord-015021-pol2qm74	8157	13	correlated	correlate	VBN
cord-015021-pol2qm74	8157	14	with	with	IN
cord-015021-pol2qm74	8157	15	complement	complement	JJ
cord-015021-pol2qm74	8157	16	activation	activation	NN
cord-015021-pol2qm74	8157	17	and	and	CC
cord-015021-pol2qm74	8157	18	more	more	JJR
cord-015021-pol2qm74	8157	19	of	of	IN
cord-015021-pol2qm74	8157	20	the	the	DT
cord-015021-pol2qm74	8157	21	Ranson	Ranson	NNP
cord-015021-pol2qm74	8157	22	's	's	POS
cord-015021-pol2qm74	8157	23	criteria	criterion	NNS
cord-015021-pol2qm74	8157	24	.	.	.
cord-015021-pol2qm74	8158	1	A	a	DT
cord-015021-pol2qm74	8158	2	clear	clear	JJ
cord-015021-pol2qm74	8158	3	relation	relation	NN
cord-015021-pol2qm74	8158	4	existed	exist	VBD
cord-015021-pol2qm74	8158	5	between	between	IN
cord-015021-pol2qm74	8158	6	the	the	DT
cord-015021-pol2qm74	8158	7	number	number	NN
cord-015021-pol2qm74	8158	8	of	of	IN
cord-015021-pol2qm74	8158	9	Ranson	Ranson	NNP
cord-015021-pol2qm74	8158	10	's	's	POS
cord-015021-pol2qm74	8158	11	signs	sign	NNS
cord-015021-pol2qm74	8158	12	and	and	CC
cord-015021-pol2qm74	8158	13	the	the	DT
cord-015021-pol2qm74	8158	14	enmplieations	enmplieation	NNS
cord-015021-pol2qm74	8158	15	'	'	POS
cord-015021-pol2qm74	8158	16	rate	rate	NN
cord-015021-pol2qm74	8158	17	(	(	-LRB-
cord-015021-pol2qm74	8158	18	1"=	1"=	CD
cord-015021-pol2qm74	8158	19	-0.766	-0.766	NNP
cord-015021-pol2qm74	8158	20	,	,	,
cord-015021-pol2qm74	8158	21	p	p	NN
cord-015021-pol2qm74	8158	22	<	<	XX
cord-015021-pol2qm74	8158	23	0.001	0.001	CD
cord-015021-pol2qm74	8158	24	)	)	-RRB-
cord-015021-pol2qm74	8158	25	.	.	.
cord-015021-pol2qm74	8159	1	The	the	DT
cord-015021-pol2qm74	8159	2	documentation	documentation	NN
cord-015021-pol2qm74	8159	3	of	of	IN
cord-015021-pol2qm74	8159	4	toxemia	toxemia	NN
cord-015021-pol2qm74	8159	5	and	and	CC
cord-015021-pol2qm74	8159	6	the	the	DT
cord-015021-pol2qm74	8159	7	complement	complement	JJ
cord-015021-pol2qm74	8159	8	activation	activation	NN
cord-015021-pol2qm74	8159	9	can	can	MD
cord-015021-pol2qm74	8159	10	not	not	RB
cord-015021-pol2qm74	8159	11	predict	predict	VB
cord-015021-pol2qm74	8159	12	the	the	DT
cord-015021-pol2qm74	8159	13	kind	kind	NN
cord-015021-pol2qm74	8159	14	and	and	CC
cord-015021-pol2qm74	8159	15	the	the	DT
cord-015021-pol2qm74	8159	16	severity	severity	NN
cord-015021-pol2qm74	8159	17	of	of	IN
cord-015021-pol2qm74	8159	18	complications	complication	NNS
cord-015021-pol2qm74	8159	19	.	.	.
cord-015021-pol2qm74	8160	1	The	the	DT
cord-015021-pol2qm74	8160	2	study	study	NN
cord-015021-pol2qm74	8160	3	of	of	IN
cord-015021-pol2qm74	8160	4	coagulation	coagulation	NN
cord-015021-pol2qm74	8160	5	,	,	,
cord-015021-pol2qm74	8160	6	fibrinolysis	fibrinolysis	NN
cord-015021-pol2qm74	8160	7	and	and	CC
cord-015021-pol2qm74	8160	8	kinms	kinms	NNP
cord-015021-pol2qm74	8160	9	systems	system	NNS
cord-015021-pol2qm74	8160	10	did	do	VBD
cord-015021-pol2qm74	8160	11	n't	not	RB
cord-015021-pol2qm74	8160	12	reveal	reveal	VB
cord-015021-pol2qm74	8160	13	any	any	DT
cord-015021-pol2qm74	8160	14	results	result	NNS
cord-015021-pol2qm74	8160	15	with	with	IN
cord-015021-pol2qm74	8160	16	statistical	statistical	JJ
cord-015021-pol2qm74	8160	17	significance	significance	NN
cord-015021-pol2qm74	8160	18	.	.	.
cord-015021-pol2qm74	8161	1	Necrotizing	necrotize	VBG
cord-015021-pol2qm74	8161	2	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8161	3	still	still	RB
cord-015021-pol2qm74	8161	4	represents	represent	VBZ
cord-015021-pol2qm74	8161	5	a	a	DT
cord-015021-pol2qm74	8161	6	life	life	NN
cord-015021-pol2qm74	8161	7	-	-	HYPH
cord-015021-pol2qm74	8161	8	threatenthg	threatenthg	NN
cord-015021-pol2qm74	8161	9	disease	disease	NN
cord-015021-pol2qm74	8161	10	.	.	.
cord-015021-pol2qm74	8162	1	Infectious	infectious	JJ
cord-015021-pol2qm74	8162	2	complications	complication	NNS
cord-015021-pol2qm74	8162	3	dominate	dominate	VBP
cord-015021-pol2qm74	8162	4	among	among	IN
cord-015021-pol2qm74	8162	5	the	the	DT
cord-015021-pol2qm74	8162	6	causes	cause	NNS
cord-015021-pol2qm74	8162	7	of	of	IN
cord-015021-pol2qm74	8162	8	death	death	NN
cord-015021-pol2qm74	8162	9	.	.	.
cord-015021-pol2qm74	8163	1	Differences	difference	NNS
cord-015021-pol2qm74	8163	2	in	in	IN
cord-015021-pol2qm74	8163	3	the	the	DT
cord-015021-pol2qm74	8163	4	individual	individual	JJ
cord-015021-pol2qm74	8163	5	immune	immune	JJ
cord-015021-pol2qm74	8163	6	response	response	NN
cord-015021-pol2qm74	8163	7	could	could	MD
cord-015021-pol2qm74	8163	8	possibly	possibly	RB
cord-015021-pol2qm74	8163	9	explain	explain	VB
cord-015021-pol2qm74	8163	10	different	different	JJ
cord-015021-pol2qm74	8163	11	clinical	clinical	JJ
cord-015021-pol2qm74	8163	12	courses	course	NNS
cord-015021-pol2qm74	8163	13	even	even	RB
cord-015021-pol2qm74	8163	14	in	in	IN
cord-015021-pol2qm74	8163	15	patients	patient	NNS
cord-015021-pol2qm74	8163	16	with	with	IN
cord-015021-pol2qm74	8163	17	comparable	comparable	JJ
cord-015021-pol2qm74	8163	18	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8163	19	morphology	morphology	NN
cord-015021-pol2qm74	8163	20	.	.	.
cord-015021-pol2qm74	8164	1	To	to	TO
cord-015021-pol2qm74	8164	2	explore	explore	VB
cord-015021-pol2qm74	8164	3	the	the	DT
cord-015021-pol2qm74	8164	4	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8164	5	response	response	NN
cord-015021-pol2qm74	8164	6	in	in	IN
cord-015021-pol2qm74	8164	7	acute	acute	JJ
cord-015021-pol2qm74	8164	8	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8164	9	,	,	,
cord-015021-pol2qm74	8164	10	the	the	DT
cord-015021-pol2qm74	8164	11	following	follow	VBG
cord-015021-pol2qm74	8164	12	investigation	investigation	NN
cord-015021-pol2qm74	8164	13	was	be	VBD
cord-015021-pol2qm74	8164	14	performed	perform	VBN
cord-015021-pol2qm74	8164	15	.	.	.
cord-015021-pol2qm74	8165	1	Methods	method	NNS
cord-015021-pol2qm74	8165	2	:	:	:
cord-015021-pol2qm74	8166	1	Peripheral	peripheral	JJ
cord-015021-pol2qm74	8166	2	-	-	HYPH
cord-015021-pol2qm74	8166	3	venous	venous	JJ
cord-015021-pol2qm74	8166	4	blood	blood	NN
cord-015021-pol2qm74	8166	5	was	be	VBD
cord-015021-pol2qm74	8166	6	withdrawn	withdraw	VBN
cord-015021-pol2qm74	8166	7	on	on	IN
cord-015021-pol2qm74	8166	8	admission	admission	NN
cord-015021-pol2qm74	8166	9	and	and	CC
cord-015021-pol2qm74	8166	10	furthermore	furthermore	RB
cord-015021-pol2qm74	8166	11	twice	twice	RB
cord-015021-pol2qm74	8166	12	weekly	weekly	RB
cord-015021-pol2qm74	8166	13	in	in	IN
cord-015021-pol2qm74	8166	14	as	as	IN
cord-015021-pol2qm74	8166	15	yet	yet	RB
cord-015021-pol2qm74	8166	16	36	36	CD
cord-015021-pol2qm74	8166	17	patients	patient	NNS
cord-015021-pol2qm74	8166	18	with	with	IN
cord-015021-pol2qm74	8166	19	acute	acute	JJ
cord-015021-pol2qm74	8166	20	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8166	21	and	and	CC
cord-015021-pol2qm74	8166	22	tested	test	VBN
cord-015021-pol2qm74	8166	23	for	for	IN
cord-015021-pol2qm74	8166	24	the	the	DT
cord-015021-pol2qm74	8166	25	parameters	parameter	NNS
cord-015021-pol2qm74	8166	26	mentioned	mention	VBN
cord-015021-pol2qm74	8166	27	below	below	RB
cord-015021-pol2qm74	8166	28	.	.	.
cord-015021-pol2qm74	8167	1	In	in	IN
cord-015021-pol2qm74	8167	2	parallel	parallel	JJ
cord-015021-pol2qm74	8167	3	,	,	,
cord-015021-pol2qm74	8167	4	polymorphounciear	polymorphounciear	NNP
cord-015021-pol2qm74	8167	5	granaIocytes	granaIocytes	NNPS
cord-015021-pol2qm74	8167	6	were	be	VBD
cord-015021-pol2qm74	8167	7	isolated	isolate	VBN
cord-015021-pol2qm74	8167	8	using	use	VBG
cord-015021-pol2qm74	8167	9	density	density	NN
cord-015021-pol2qm74	8167	10	gradient	gradient	NN
cord-015021-pol2qm74	8167	11	centrifugation	centrifugation	NN
cord-015021-pol2qm74	8167	12	and	and	CC
cord-015021-pol2qm74	8167	13	assessed	assess	VBN
cord-015021-pol2qm74	8167	14	for	for	IN
cord-015021-pol2qm74	8167	15	superoxide	superoxide	NN
cord-015021-pol2qm74	8167	16	anion	anion	NN
cord-015021-pol2qm74	8167	17	and	and	CC
cord-015021-pol2qm74	8167	18	hydroxyl	hydroxyl	NN
cord-015021-pol2qm74	8167	19	radical	radical	JJ
cord-015021-pol2qm74	8167	20	producing	produce	VBG
cord-015021-pol2qm74	8167	21	capacity	capacity	NN
cord-015021-pol2qm74	8167	22	using	use	VBG
cord-015021-pol2qm74	8167	23	electron	electron	NN
cord-015021-pol2qm74	8167	24	spin	spin	NN
cord-015021-pol2qm74	8167	25	resonance	resonance	NN
cord-015021-pol2qm74	8167	26	techniques	technique	NNS
cord-015021-pol2qm74	8167	27	.	.	.
cord-015021-pol2qm74	8168	1	Results	result	NNS
cord-015021-pol2qm74	8168	2	:	:	:
cord-015021-pol2qm74	8168	3	Total	total	JJ
cord-015021-pol2qm74	8168	4	leukocyte	leukocyte	NN
cord-015021-pol2qm74	8168	5	cotmt	cotmt	NN
cord-015021-pol2qm74	8168	6	and	and	CC
cord-015021-pol2qm74	8168	7	total	total	JJ
cord-015021-pol2qm74	8168	8	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	8168	9	count	count	NN
cord-015021-pol2qm74	8169	1	did	do	VBD
cord-015021-pol2qm74	8169	2	neither	neither	CC
cord-015021-pol2qm74	8169	3	reflect	reflect	VB
cord-015021-pol2qm74	8169	4	the	the	DT
cord-015021-pol2qm74	8169	5	clinical	clinical	JJ
cord-015021-pol2qm74	8169	6	course	course	NN
cord-015021-pol2qm74	8169	7	nor	nor	CC
cord-015021-pol2qm74	8169	8	predict	predict	VB
cord-015021-pol2qm74	8169	9	complications	complication	NNS
cord-015021-pol2qm74	8169	10	.	.	.
cord-015021-pol2qm74	8170	1	This	this	DT
cord-015021-pol2qm74	8170	2	comes	come	VBZ
cord-015021-pol2qm74	8170	3	tree	tree	NN
cord-015021-pol2qm74	8170	4	also	also	RB
cord-015021-pol2qm74	8170	5	for	for	IN
cord-015021-pol2qm74	8170	6	serum	serum	NN
cord-015021-pol2qm74	8170	7	IgG	IgG	NNP
cord-015021-pol2qm74	8170	8	,	,	,
cord-015021-pol2qm74	8170	9	IgM	IgM	NNP
cord-015021-pol2qm74	8170	10	,	,	,
cord-015021-pol2qm74	8170	11	IgA	IgA	NNP
cord-015021-pol2qm74	8170	12	,	,	,
cord-015021-pol2qm74	8170	13	C3	C3	NNP
cord-015021-pol2qm74	8170	14	,	,	,
cord-015021-pol2qm74	8170	15	C4	C4	NNP
cord-015021-pol2qm74	8170	16	,	,	,
cord-015021-pol2qm74	8170	17	CRP	CRP	NNP
cord-015021-pol2qm74	8170	18	,	,	,
cord-015021-pol2qm74	8170	19	alpha	alpha	NN
cord-015021-pol2qm74	8170	20	-	-	HYPH
cord-015021-pol2qm74	8170	21	l	l	NN
cord-015021-pol2qm74	8170	22	-	-	HYPH
cord-015021-pol2qm74	8170	23	antitrypsin	antitrypsin	NN
cord-015021-pol2qm74	8170	24	and	and	CC
cord-015021-pol2qm74	8170	25	neopterth	neopterth	JJ
cord-015021-pol2qm74	8170	26	as	as	RB
cord-015021-pol2qm74	8170	27	well	well	RB
cord-015021-pol2qm74	8170	28	as	as	IN
cord-015021-pol2qm74	8170	29	for	for	IN
cord-015021-pol2qm74	8170	30	plasma	plasma	NN
cord-015021-pol2qm74	8170	31	IL	IL	NNP
cord-015021-pol2qm74	8170	32	-	-	HYPH
cord-015021-pol2qm74	8170	33	la	la	NNP
cord-015021-pol2qm74	8170	34	,	,	,
cord-015021-pol2qm74	8170	35	IL	IL	NNP
cord-015021-pol2qm74	8170	36	-	-	HYPH
cord-015021-pol2qm74	8170	37	IB	IB	NNP
cord-015021-pol2qm74	8170	38	,	,	,
cord-015021-pol2qm74	8170	39	IL-1RA	IL-1RA	NNP
cord-015021-pol2qm74	8170	40	,	,	,
cord-015021-pol2qm74	8170	41	IL-2	IL-2	NNP
cord-015021-pol2qm74	8170	42	,	,	,
cord-015021-pol2qm74	8170	43	IL-2R	IL-2R	NNP
cord-015021-pol2qm74	8170	44	,	,	,
cord-015021-pol2qm74	8170	45	IL-6R	IL-6R	NNP
cord-015021-pol2qm74	8170	46	,	,	,
cord-015021-pol2qm74	8170	47	TNF	TNF	NNP
cord-015021-pol2qm74	8170	48	-	-	HYPH
cord-015021-pol2qm74	8170	49	ct	ct	NNP
cord-015021-pol2qm74	8170	50	,	,	,
cord-015021-pol2qm74	8170	51	TNF-~R	TNF-~R	NNP
cord-015021-pol2qm74	8170	52	(	(	-LRB-
cord-015021-pol2qm74	8170	53	p75	p75	NNP
cord-015021-pol2qm74	8170	54	)	)	-RRB-
cord-015021-pol2qm74	8170	55	and	and	CC
cord-015021-pol2qm74	8170	56	ICAM-1	ICAM-1	NNP
cord-015021-pol2qm74	8170	57	.	.	.
cord-015021-pol2qm74	8171	1	In	in	IN
cord-015021-pol2qm74	8171	2	contrast	contrast	NN
cord-015021-pol2qm74	8171	3	,	,	,
cord-015021-pol2qm74	8171	4	PMN	pmn	NN
cord-015021-pol2qm74	8171	5	-	-	HYPH
cord-015021-pol2qm74	8171	6	elastase	elastase	NN
cord-015021-pol2qm74	8171	7	,	,	,
cord-015021-pol2qm74	8171	8	IL-6	IL-6	NNP
cord-015021-pol2qm74	8171	9	and	and	CC
cord-015021-pol2qm74	8171	10	IL-8	IL-8	NNP
cord-015021-pol2qm74	8171	11	closely	closely	RB
cord-015021-pol2qm74	8171	12	correlated	correlate	VBD
cord-015021-pol2qm74	8171	13	to	to	IN
cord-015021-pol2qm74	8171	14	the	the	DT
cord-015021-pol2qm74	8171	15	clinical	clinical	JJ
cord-015021-pol2qm74	8171	16	course	course	NN
cord-015021-pol2qm74	8171	17	.	.	.
cord-015021-pol2qm74	8172	1	Isolated	isolated	JJ
cord-015021-pol2qm74	8172	2	PMN	PMN	NNP
cord-015021-pol2qm74	8172	3	's	's	POS
cord-015021-pol2qm74	8172	4	in	in	IN
cord-015021-pol2qm74	8172	5	vitro	vitro	FW
cord-015021-pol2qm74	8172	6	capacity	capacity	NN
cord-015021-pol2qm74	8172	7	to	to	TO
cord-015021-pol2qm74	8172	8	produce	produce	VB
cord-015021-pol2qm74	8172	9	oxygen	oxygen	NN
cord-015021-pol2qm74	8172	10	radicals	radical	NNS
cord-015021-pol2qm74	8172	11	depended	depend	VBN
cord-015021-pol2qm74	8172	12	on	on	IN
cord-015021-pol2qm74	8172	13	the	the	DT
cord-015021-pol2qm74	8172	14	respective	respective	JJ
cord-015021-pol2qm74	8172	15	radical	radical	JJ
cord-015021-pol2qm74	8172	16	species	specie	NNS
cord-015021-pol2qm74	8172	17	and	and	CC
cord-015021-pol2qm74	8172	18	was	be	VBD
cord-015021-pol2qm74	8172	19	slightly	slightly	RB
cord-015021-pol2qm74	8172	20	elevated	elevated	JJ
cord-015021-pol2qm74	8172	21	(	(	-LRB-
cord-015021-pol2qm74	8172	22	superoxide	superoxide	NN
cord-015021-pol2qm74	8172	23	anions	anion	NNS
cord-015021-pol2qm74	8172	24	)	)	-RRB-
cord-015021-pol2qm74	8172	25	or	or	CC
cord-015021-pol2qm74	8172	26	decreased	decrease	VBN
cord-015021-pol2qm74	8172	27	(	(	-LRB-
cord-015021-pol2qm74	8172	28	hydroxyl	hydroxyl	NN
cord-015021-pol2qm74	8172	29	radicals	radical	NNS
cord-015021-pol2qm74	8172	30	)	)	-RRB-
cord-015021-pol2qm74	8172	31	,	,	,
cord-015021-pol2qm74	8172	32	respectively	respectively	RB
cord-015021-pol2qm74	8172	33	.	.	.
cord-015021-pol2qm74	8173	1	Patients	patient	NNS
cord-015021-pol2qm74	8173	2	with	with	IN
cord-015021-pol2qm74	8173	3	a	a	DT
cord-015021-pol2qm74	8173	4	CD4+/CD8	cd4+/cd8	NN
cord-015021-pol2qm74	8174	1	+	+	CC
cord-015021-pol2qm74	8175	1	ratio	ratio	NN
cord-015021-pol2qm74	8175	2	below	below	IN
cord-015021-pol2qm74	8175	3	i	i	PRP
cord-015021-pol2qm74	8175	4	were	be	VBD
cord-015021-pol2qm74	8175	5	seen	see	VBN
cord-015021-pol2qm74	8175	6	at	at	IN
cord-015021-pol2qm74	8175	7	risk	risk	NN
cord-015021-pol2qm74	8175	8	of	of	IN
cord-015021-pol2qm74	8175	9	developing	develop	VBG
cord-015021-pol2qm74	8175	10	septic	septic	JJ
cord-015021-pol2qm74	8175	11	complications	complication	NNS
cord-015021-pol2qm74	8175	12	.	.	.
cord-015021-pol2qm74	8176	1	In	in	IN
cord-015021-pol2qm74	8176	2	contrast	contrast	NN
cord-015021-pol2qm74	8176	3	,	,	,
cord-015021-pol2qm74	8176	4	a	a	DT
cord-015021-pol2qm74	8176	5	percentage	percentage	NN
cord-015021-pol2qm74	8176	6	of	of	IN
cord-015021-pol2qm74	8176	7	monocytes	monocyte	NNS
cord-015021-pol2qm74	8176	8	of	of	IN
cord-015021-pol2qm74	8176	9	30	30	CD
cord-015021-pol2qm74	8176	10	%	%	NN
cord-015021-pol2qm74	8176	11	or	or	CC
cord-015021-pol2qm74	8176	12	more	more	JJR
cord-015021-pol2qm74	8176	13	among	among	IN
cord-015021-pol2qm74	8176	14	total	total	JJ
cord-015021-pol2qm74	8176	15	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	8176	16	cells	cell	NNS
cord-015021-pol2qm74	8176	17	indicated	indicate	VBD
cord-015021-pol2qm74	8176	18	an	an	DT
cord-015021-pol2qm74	8176	19	uncomplicated	uncomplicated	JJ
cord-015021-pol2qm74	8176	20	course	course	NN
cord-015021-pol2qm74	8176	21	,	,	,
cord-015021-pol2qm74	8176	22	in	in	IN
cord-015021-pol2qm74	8176	23	general	general	JJ
cord-015021-pol2qm74	8176	24	.	.	.
cord-015021-pol2qm74	8177	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	8177	2	:	:	:
cord-015021-pol2qm74	8178	1	The	the	DT
cord-015021-pol2qm74	8178	2	immune	immune	JJ
cord-015021-pol2qm74	8178	3	status	status	NN
cord-015021-pol2qm74	8178	4	of	of	IN
cord-015021-pol2qm74	8178	5	the	the	DT
cord-015021-pol2qm74	8178	6	individual	individual	JJ
cord-015021-pol2qm74	8178	7	patient	patient	NN
cord-015021-pol2qm74	8178	8	may	may	MD
cord-015021-pol2qm74	8178	9	significantly	significantly	RB
cord-015021-pol2qm74	8178	10	influence	influence	VB
cord-015021-pol2qm74	8178	11	the	the	DT
cord-015021-pol2qm74	8178	12	course	course	NN
cord-015021-pol2qm74	8178	13	of	of	IN
cord-015021-pol2qm74	8178	14	acute	acute	JJ
cord-015021-pol2qm74	8178	15	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8178	16	.	.	.
cord-015021-pol2qm74	8179	1	The	the	DT
cord-015021-pol2qm74	8179	2	cytokine	cytokine	NN
cord-015021-pol2qm74	8179	3	pattern	pattern	NN
cord-015021-pol2qm74	8179	4	in	in	IN
cord-015021-pol2qm74	8179	5	peripheral	peripheral	JJ
cord-015021-pol2qm74	8179	6	blood	blood	NN
cord-015021-pol2qm74	8179	7	is	be	VBZ
cord-015021-pol2qm74	8179	8	very	very	RB
cord-015021-pol2qm74	8179	9	complex	complex	JJ
cord-015021-pol2qm74	8179	10	and	and	CC
cord-015021-pol2qm74	8179	11	most	most	JJS
cord-015021-pol2qm74	8179	12	parameters	parameter	NNS
cord-015021-pol2qm74	8179	13	are	be	VBP
cord-015021-pol2qm74	8179	14	of	of	IN
cord-015021-pol2qm74	8179	15	little	little	JJ
cord-015021-pol2qm74	8179	16	use	use	NN
cord-015021-pol2qm74	8179	17	for	for	IN
cord-015021-pol2qm74	8179	18	the	the	DT
cord-015021-pol2qm74	8179	19	clinician	clinician	NN
cord-015021-pol2qm74	8179	20	.	.	.
cord-015021-pol2qm74	8180	1	The	the	DT
cord-015021-pol2qm74	8180	2	PMN	pmn	NN
cord-015021-pol2qm74	8180	3	-	-	HYPH
cord-015021-pol2qm74	8180	4	elastase	elastase	NN
cord-015021-pol2qm74	8180	5	,	,	,
cord-015021-pol2qm74	8180	6	IL-6	IL-6	NNP
cord-015021-pol2qm74	8180	7	and	and	CC
cord-015021-pol2qm74	8180	8	IL-8	IL-8	NNP
cord-015021-pol2qm74	8180	9	,	,	,
cord-015021-pol2qm74	8180	10	however	however	RB
cord-015021-pol2qm74	8180	11	,	,	,
cord-015021-pol2qm74	8180	12	closely	closely	RB
cord-015021-pol2qm74	8180	13	correlate	correlate	VB
cord-015021-pol2qm74	8180	14	to	to	IN
cord-015021-pol2qm74	8180	15	the	the	DT
cord-015021-pol2qm74	8180	16	clinical	clinical	JJ
cord-015021-pol2qm74	8180	17	course	course	NN
cord-015021-pol2qm74	8180	18	and	and	CC
cord-015021-pol2qm74	8180	19	may	may	MD
cord-015021-pol2qm74	8180	20	prove	prove	VB
cord-015021-pol2qm74	8180	21	valuable	valuable	JJ
cord-015021-pol2qm74	8180	22	for	for	IN
cord-015021-pol2qm74	8180	23	follow	follow	NN
cord-015021-pol2qm74	8180	24	-	-	HYPH
cord-015021-pol2qm74	8180	25	up	up	NN
cord-015021-pol2qm74	8180	26	.	.	.
cord-015021-pol2qm74	8181	1	The	the	DT
cord-015021-pol2qm74	8181	2	CD4+/CD8	cd4+/cd8	NN
cord-015021-pol2qm74	8181	3	+	+	CC
cord-015021-pol2qm74	8181	4	ratio	ratio	NN
cord-015021-pol2qm74	8181	5	was	be	VBD
cord-015021-pol2qm74	8181	6	found	find	VBN
cord-015021-pol2qm74	8181	7	the	the	DT
cord-015021-pol2qm74	8181	8	best	good	JJS
cord-015021-pol2qm74	8181	9	predictor	predictor	NN
cord-015021-pol2qm74	8181	10	of	of	IN
cord-015021-pol2qm74	8181	11	septic	septic	JJ
cord-015021-pol2qm74	8181	12	complications	complication	NNS
cord-015021-pol2qm74	8181	13	,	,	,
cord-015021-pol2qm74	8181	14	but	but	CC
cord-015021-pol2qm74	8181	15	it	-PRON-	PRP
cord-015021-pol2qm74	8181	16	failed	fail	VBD
cord-015021-pol2qm74	8181	17	in	in	IN
cord-015021-pol2qm74	8181	18	non	non	JJ
cord-015021-pol2qm74	8181	19	-	-	JJ
cord-015021-pol2qm74	8181	20	septic	septic	JJ
cord-015021-pol2qm74	8181	21	patients	patient	NNS
cord-015021-pol2qm74	8181	22	.	.	.
cord-015021-pol2qm74	8182	1	A	a	DT
cord-015021-pol2qm74	8182	2	percentage	percentage	NN
cord-015021-pol2qm74	8182	3	of	of	IN
cord-015021-pol2qm74	8182	4	30	30	CD
cord-015021-pol2qm74	8182	5	%	%	NN
cord-015021-pol2qm74	8182	6	or	or	CC
cord-015021-pol2qm74	8182	7	more	more	JJR
cord-015021-pol2qm74	8182	8	of	of	IN
cord-015021-pol2qm74	8182	9	monocytes	monocyte	NNS
cord-015021-pol2qm74	8182	10	among	among	IN
cord-015021-pol2qm74	8182	11	total	total	JJ
cord-015021-pol2qm74	8182	12	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	8182	13	ceils	ceil	NNS
cord-015021-pol2qm74	8182	14	indicated	indicate	VBD
cord-015021-pol2qm74	8182	15	a	a	DT
cord-015021-pol2qm74	8182	16	rather	rather	RB
cord-015021-pol2qm74	8182	17	mild	mild	JJ
cord-015021-pol2qm74	8182	18	course	course	NN
cord-015021-pol2qm74	8182	19	.	.	.
cord-015021-pol2qm74	8183	1	The	the	DT
cord-015021-pol2qm74	8183	2	reduced	reduce	VBN
cord-015021-pol2qm74	8183	3	ability	ability	NN
cord-015021-pol2qm74	8183	4	of	of	IN
cord-015021-pol2qm74	8183	5	the	the	DT
cord-015021-pol2qm74	8183	6	PMNs	pmn	NNS
cord-015021-pol2qm74	8183	7	to	to	TO
cord-015021-pol2qm74	8183	8	produce	produce	VB
cord-015021-pol2qm74	8183	9	hydroxyl	hydroxyl	NN
cord-015021-pol2qm74	8183	10	radicals	radical	NNS
cord-015021-pol2qm74	8183	11	may	may	MD
cord-015021-pol2qm74	8183	12	help	help	VB
cord-015021-pol2qm74	8183	13	to	to	TO
cord-015021-pol2qm74	8183	14	explain	explain	VB
cord-015021-pol2qm74	8183	15	the	the	DT
cord-015021-pol2qm74	8183	16	frequent	frequent	JJ
cord-015021-pol2qm74	8183	17	development	development	NN
cord-015021-pol2qm74	8183	18	of	of	IN
cord-015021-pol2qm74	8183	19	septic	septic	JJ
cord-015021-pol2qm74	8183	20	complications	complication	NNS
cord-015021-pol2qm74	8183	21	in	in	IN
cord-015021-pol2qm74	8183	22	severe	severe	JJ
cord-015021-pol2qm74	8183	23	necmtizing	necmtize	VBG
cord-015021-pol2qm74	8183	24	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8183	25	.	.	.
cord-015021-pol2qm74	8184	1	Peroxidation	peroxidation	NN
cord-015021-pol2qm74	8184	2	of	of	IN
cord-015021-pol2qm74	8184	3	membrane	membrane	NN
cord-015021-pol2qm74	8184	4	lipids	lipid	NNS
cord-015021-pol2qm74	8184	5	contributes	contribute	VBZ
cord-015021-pol2qm74	8184	6	to	to	IN
cord-015021-pol2qm74	8184	7	ceil	ceil	NN
cord-015021-pol2qm74	8184	8	injury	injury	NN
cord-015021-pol2qm74	8184	9	in	in	IN
cord-015021-pol2qm74	8184	10	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8184	11	.	.	.
cord-015021-pol2qm74	8185	1	Overwhelming	overwhelming	JJ
cord-015021-pol2qm74	8185	2	release	release	NN
cord-015021-pol2qm74	8185	3	of	of	IN
cord-015021-pol2qm74	8185	4	toxic	toxic	JJ
cord-015021-pol2qm74	8185	5	metabolites	metabolite	NNS
cord-015021-pol2qm74	8185	6	by	by	IN
cord-015021-pol2qm74	8185	7	infiltrating	infiltrate	VBG
cord-015021-pol2qm74	8185	8	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8185	9	is	be	VBZ
cord-015021-pol2qm74	8185	10	regarded	regard	VBN
cord-015021-pol2qm74	8185	11	a	a	DT
cord-015021-pol2qm74	8185	12	major	major	JJ
cord-015021-pol2qm74	8185	13	pathogenetic	pathogenetic	JJ
cord-015021-pol2qm74	8185	14	factor	factor	NN
cord-015021-pol2qm74	8185	15	,	,	,
cord-015021-pol2qm74	8185	16	too	too	RB
cord-015021-pol2qm74	8185	17	.	.	.
cord-015021-pol2qm74	8186	1	As	as	IN
cord-015021-pol2qm74	8186	2	yet	yet	RB
cord-015021-pol2qm74	8186	3	little	little	JJ
cord-015021-pol2qm74	8186	4	is	be	VBZ
cord-015021-pol2qm74	8186	5	known	know	VBN
cord-015021-pol2qm74	8186	6	about	about	IN
cord-015021-pol2qm74	8186	7	the	the	DT
cord-015021-pol2qm74	8186	8	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8186	9	by	by	IN
cord-015021-pol2qm74	8186	10	which	which	WDT
cord-015021-pol2qm74	8186	11	oxidative	oxidative	JJ
cord-015021-pol2qm74	8186	12	stress	stress	NN
cord-015021-pol2qm74	8186	13	and	and	CC
cord-015021-pol2qm74	8186	14	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	8186	15	damage	damage	NN
cord-015021-pol2qm74	8186	16	pancreatic	pancreatic	NN
cord-015021-pol2qm74	8186	17	cells	cell	NNS
cord-015021-pol2qm74	8186	18	.	.	.
cord-015021-pol2qm74	8187	1	The	the	DT
cord-015021-pol2qm74	8187	2	present	present	JJ
cord-015021-pol2qm74	8187	3	study	study	NN
cord-015021-pol2qm74	8187	4	examines	examine	VBZ
cord-015021-pol2qm74	8188	1	(	(	-LRB-
cord-015021-pol2qm74	8188	2	I	i	NN
cord-015021-pol2qm74	8188	3	)	)	-RRB-
cord-015021-pol2qm74	8189	1	the	the	DT
cord-015021-pol2qm74	8189	2	susceptibility	susceptibility	NN
cord-015021-pol2qm74	8189	3	of	of	IN
cord-015021-pol2qm74	8189	4	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8189	5	acinar	acinar	NN
cord-015021-pol2qm74	8189	6	cells	cell	NNS
cord-015021-pol2qm74	8189	7	to	to	IN
cord-015021-pol2qm74	8189	8	attacks	attack	NNS
cord-015021-pol2qm74	8189	9	by	by	IN
cord-015021-pol2qm74	8189	10	oxidants	oxidant	NNS
cord-015021-pol2qm74	8189	11	and	and	CC
cord-015021-pol2qm74	8189	12	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	8189	13	and	and	CC
cord-015021-pol2qm74	8189	14	(	(	-LRB-
cord-015021-pol2qm74	8189	15	2	2	LS
cord-015021-pol2qm74	8189	16	)	)	-RRB-
cord-015021-pol2qm74	8189	17	the	the	DT
cord-015021-pol2qm74	8189	18	potential	potential	NN
cord-015021-pol2qm74	8189	19	of	of	IN
cord-015021-pol2qm74	8189	20	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	8189	21	to	to	TO
cord-015021-pol2qm74	8189	22	prevent	prevent	VB
cord-015021-pol2qm74	8189	23	such	such	JJ
cord-015021-pol2qm74	8189	24	damage	damage	NN
cord-015021-pol2qm74	8189	25	in	in	IN
cord-015021-pol2qm74	8189	26	order	order	NN
cord-015021-pol2qm74	8189	27	to	to	TO
cord-015021-pol2qm74	8189	28	better	better	RB
cord-015021-pol2qm74	8189	29	understand	understand	VB
cord-015021-pol2qm74	8189	30	the	the	DT
cord-015021-pol2qm74	8189	31	cellular	cellular	JJ
cord-015021-pol2qm74	8189	32	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8189	33	of	of	IN
cord-015021-pol2qm74	8189	34	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8189	35	injury	injury	NN
cord-015021-pol2qm74	8189	36	in	in	IN
cord-015021-pol2qm74	8189	37	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8189	38	states	state	NNS
cord-015021-pol2qm74	8189	39	.	.	.
cord-015021-pol2qm74	8190	1	Methods	method	NNS
cord-015021-pol2qm74	8190	2	:	:	:
cord-015021-pol2qm74	8190	3	Freshly	freshly	RB
cord-015021-pol2qm74	8190	4	isolated	isolate	VBN
cord-015021-pol2qm74	8190	5	rat	rat	NN
cord-015021-pol2qm74	8190	6	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8190	7	acinar	acinar	NNP
cord-015021-pol2qm74	8190	8	ceils	ceil	NNS
cord-015021-pol2qm74	8190	9	were	be	VBD
cord-015021-pol2qm74	8190	10	exposed	expose	VBN
cord-015021-pol2qm74	8190	11	to	to	IN
cord-015021-pol2qm74	8190	12	a	a	DT
cord-015021-pol2qm74	8190	13	model	model	NN
cord-015021-pol2qm74	8190	14	system	system	NN
cord-015021-pol2qm74	8190	15	of	of	IN
cord-015021-pol2qm74	8190	16	oxidative	oxidative	JJ
cord-015021-pol2qm74	8190	17	stress	stress	NN
cord-015021-pol2qm74	8190	18	consisting	consist	VBG
cord-015021-pol2qm74	8190	19	of	of	IN
cord-015021-pol2qm74	8190	20	20	20	CD
cord-015021-pol2qm74	8190	21	mU	mU	NNS
cord-015021-pol2qm74	8190	22	/	/	SYM
cord-015021-pol2qm74	8190	23	ml	ml	NN
cord-015021-pol2qm74	8190	24	xanthine	xanthine	NN
cord-015021-pol2qm74	8190	25	oxidase	oxidase	NN
cord-015021-pol2qm74	8190	26	(	(	-LRB-
cord-015021-pol2qm74	8190	27	XOD	XOD	NNP
cord-015021-pol2qm74	8190	28	)	)	-RRB-
cord-015021-pol2qm74	8190	29	,	,	,
cord-015021-pol2qm74	8190	30	500	500	CD
cord-015021-pol2qm74	8190	31	mM	mm	CD
cord-015021-pol2qm74	8190	32	hypoxanthine	hypoxanthine	NN
cord-015021-pol2qm74	8190	33	(	(	-LRB-
cord-015021-pol2qm74	8190	34	HX	HX	NNP
cord-015021-pol2qm74	8190	35	)	)	-RRB-
cord-015021-pol2qm74	8190	36	,	,	,
cord-015021-pol2qm74	8190	37	50	50	CD
cord-015021-pol2qm74	8190	38	mM	mm	CD
cord-015021-pol2qm74	8190	39	FeC13	FeC13	NNS
cord-015021-pol2qm74	8190	40	and	and	CC
cord-015021-pol2qm74	8190	41	75	75	CD
cord-015021-pol2qm74	8190	42	mM	mm	CD
cord-015021-pol2qm74	8190	43	EDTA	edta	NN
cord-015021-pol2qm74	8190	44	.	.	.
cord-015021-pol2qm74	8191	1	In	in	IN
cord-015021-pol2qm74	8191	2	a	a	DT
cord-015021-pol2qm74	8191	3	second	second	JJ
cord-015021-pol2qm74	8191	4	set	set	NN
cord-015021-pol2qm74	8191	5	of	of	IN
cord-015021-pol2qm74	8191	6	experiments	experiment	NNS
cord-015021-pol2qm74	8191	7	,	,	,
cord-015021-pol2qm74	8191	8	acinar	acinar	NN
cord-015021-pol2qm74	8191	9	cells	cell	NNS
cord-015021-pol2qm74	8191	10	were	be	VBD
cord-015021-pol2qm74	8191	11	exposed	expose	VBN
cord-015021-pol2qm74	8191	12	to	to	IN
cord-015021-pol2qm74	8191	13	excess	excess	JJ
cord-015021-pol2qm74	8191	14	autologous	autologous	JJ
cord-015021-pol2qm74	8191	15	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8191	16	or	or	CC
cord-015021-pol2qm74	8191	17	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8191	18	obtained	obtain	VBN
cord-015021-pol2qm74	8191	19	from	from	IN
cord-015021-pol2qm74	8191	20	patients	patient	NNS
cord-015021-pol2qm74	8191	21	with	with	IN
cord-015021-pol2qm74	8191	22	acute	acute	JJ
cord-015021-pol2qm74	8191	23	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8191	24	.	.	.
cord-015021-pol2qm74	8192	1	Neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8192	2	were	be	VBD
cord-015021-pol2qm74	8192	3	stimulated	stimulate	VBN
cord-015021-pol2qm74	8192	4	by	by	IN
cord-015021-pol2qm74	8192	5	zymosan	zymosan	NNP
cord-015021-pol2qm74	8192	6	A	A	NNP
cord-015021-pol2qm74	8192	7	,	,	,
cord-015021-pol2qm74	8192	8	PMA	PMA	NNP
cord-015021-pol2qm74	8192	9	,	,	,
cord-015021-pol2qm74	8192	10	and	and	CC
cord-015021-pol2qm74	8192	11	IL-8	IL-8	NNP
cord-015021-pol2qm74	8192	12	.	.	.
cord-015021-pol2qm74	8193	1	Cell	cell	NN
cord-015021-pol2qm74	8193	2	viability	viability	NN
cord-015021-pol2qm74	8193	3	was	be	VBD
cord-015021-pol2qm74	8193	4	assessed	assess	VBN
cord-015021-pol2qm74	8193	5	by	by	IN
cord-015021-pol2qm74	8193	6	both	both	DT
cord-015021-pol2qm74	8193	7	cellular	cellular	JJ
cord-015021-pol2qm74	8193	8	uptake	uptake	NN
cord-015021-pol2qm74	8193	9	of	of	IN
cord-015021-pol2qm74	8193	10	trypan	trypan	NNP
cord-015021-pol2qm74	8193	11	blue	blue	NNP
cord-015021-pol2qm74	8193	12	(	(	-LRB-
cord-015021-pol2qm74	8193	13	TB	TB	NNP
cord-015021-pol2qm74	8193	14	)	)	-RRB-
cord-015021-pol2qm74	8193	15	and	and	CC
cord-015021-pol2qm74	8193	16	by	by	IN
cord-015021-pol2qm74	8193	17	release	release	NN
cord-015021-pol2qm74	8193	18	of	of	IN
cord-015021-pol2qm74	8193	19	LDH	LDH	NNP
cord-015021-pol2qm74	8193	20	.	.	.
cord-015021-pol2qm74	8194	1	Results	result	NNS
cord-015021-pol2qm74	8194	2	:	:	:
cord-015021-pol2qm74	8195	1	The	the	DT
cord-015021-pol2qm74	8195	2	XOD	XOD	NNP
cord-015021-pol2qm74	8195	3	/	/	SYM
cord-015021-pol2qm74	8195	4	HX	hx	NN
cord-015021-pol2qm74	8195	5	system	system	NN
cord-015021-pol2qm74	8195	6	caused	cause	VBD
cord-015021-pol2qm74	8195	7	a	a	DT
cord-015021-pol2qm74	8195	8	time	time	NN
cord-015021-pol2qm74	8195	9	-	-	HYPH
cord-015021-pol2qm74	8195	10	dependent	dependent	JJ
cord-015021-pol2qm74	8195	11	acinar	acinar	JJ
cord-015021-pol2qm74	8195	12	cell	cell	NN
cord-015021-pol2qm74	8195	13	injury	injury	NN
cord-015021-pol2qm74	8195	14	.	.	.
cord-015021-pol2qm74	8196	1	This	this	DT
cord-015021-pol2qm74	8196	2	injury	injury	NN
cord-015021-pol2qm74	8196	3	was	be	VBD
cord-015021-pol2qm74	8196	4	effectively	effectively	RB
cord-015021-pol2qm74	8196	5	prevented	prevent	VBN
cord-015021-pol2qm74	8196	6	by	by	IN
cord-015021-pol2qm74	8196	7	catalase	catalase	NN
cord-015021-pol2qm74	8196	8	(	(	-LRB-
cord-015021-pol2qm74	8196	9	CAT	CAT	NNP
cord-015021-pol2qm74	8196	10	)	)	-RRB-
cord-015021-pol2qm74	8196	11	and	and	CC
cord-015021-pol2qm74	8196	12	gfutathione	gfutathione	NNP
cord-015021-pol2qm74	8196	13	peroxidase	peroxidase	NN
cord-015021-pol2qm74	8196	14	(	(	-LRB-
cord-015021-pol2qm74	8196	15	GPx	GPx	NNS
cord-015021-pol2qm74	8196	16	)	)	-RRB-
cord-015021-pol2qm74	8196	17	.	.	.
cord-015021-pol2qm74	8197	1	In	in	IN
cord-015021-pol2qm74	8197	2	comrast	comrast	JJ
cord-015021-pol2qm74	8197	3	,	,	,
cord-015021-pol2qm74	8197	4	superoxide	superoxide	NN
cord-015021-pol2qm74	8197	5	dismutase	dismutase	NN
cord-015021-pol2qm74	8197	6	(	(	-LRB-
cord-015021-pol2qm74	8197	7	SOD	SOD	NNP
cord-015021-pol2qm74	8197	8	)	)	-RRB-
cord-015021-pol2qm74	8197	9	enhanced	enhance	VBN
cord-015021-pol2qm74	8197	10	cell	cell	NN
cord-015021-pol2qm74	8197	11	injury	injury	NN
cord-015021-pol2qm74	8197	12	.	.	.
cord-015021-pol2qm74	8198	1	Addition	addition	NN
cord-015021-pol2qm74	8198	2	of	of	IN
cord-015021-pol2qm74	8198	3	both	both	DT
cord-015021-pol2qm74	8198	4	SOD	SOD	NNP
cord-015021-pol2qm74	8198	5	and	and	CC
cord-015021-pol2qm74	8198	6	CAT	CAT	NNP
cord-015021-pol2qm74	8198	7	abolished	abolish	VBD
cord-015021-pol2qm74	8198	8	the	the	DT
cord-015021-pol2qm74	8198	9	damage	damage	NN
cord-015021-pol2qm74	8198	10	seen	see	VBN
cord-015021-pol2qm74	8198	11	with	with	IN
cord-015021-pol2qm74	8198	12	SOD	SOD	NNP
cord-015021-pol2qm74	8198	13	alone	alone	RB
cord-015021-pol2qm74	8198	14	.	.	.
cord-015021-pol2qm74	8199	1	The	the	DT
cord-015021-pol2qm74	8199	2	non	non	JJ
cord-015021-pol2qm74	8199	3	-	-	JJ
cord-015021-pol2qm74	8199	4	enzymatic	enzymatic	JJ
cord-015021-pol2qm74	8199	5	scavengers	scavenger	NNS
cord-015021-pol2qm74	8199	6	mannitol	mannitol	NN
cord-015021-pol2qm74	8199	7	,	,	,
cord-015021-pol2qm74	8199	8	DMSO	DMSO	NNP
cord-015021-pol2qm74	8199	9	,	,	,
cord-015021-pol2qm74	8199	10	DMTU	DMTU	NNP
cord-015021-pol2qm74	8199	11	and	and	CC
cord-015021-pol2qm74	8199	12	the	the	DT
cord-015021-pol2qm74	8199	13	iron	iron	NN
cord-015021-pol2qm74	8199	14	chelator	chelator	NN
cord-015021-pol2qm74	8199	15	deferoxamine	deferoxamine	NNP
cord-015021-pol2qm74	8199	16	were	be	VBD
cord-015021-pol2qm74	8199	17	not	not	RB
cord-015021-pol2qm74	8199	18	protective	protective	JJ
cord-015021-pol2qm74	8199	19	and	and	CC
cord-015021-pol2qm74	8199	20	at	at	IN
cord-015021-pol2qm74	8199	21	a	a	DT
cord-015021-pol2qm74	8199	22	higher	high	JJR
cord-015021-pol2qm74	8199	23	concentration	concentration	NN
cord-015021-pol2qm74	8199	24	even	even	RB
cord-015021-pol2qm74	8199	25	accelerated	accelerate	VBD
cord-015021-pol2qm74	8199	26	cell	cell	NN
cord-015021-pol2qm74	8199	27	decline	decline	NN
cord-015021-pol2qm74	8199	28	.	.	.
cord-015021-pol2qm74	8200	1	The	the	DT
cord-015021-pol2qm74	8200	2	newly	newly	RB
cord-015021-pol2qm74	8200	3	developed	develop	VBN
cord-015021-pol2qm74	8200	4	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	8200	5	of	of	IN
cord-015021-pol2qm74	8200	6	the	the	DT
cord-015021-pol2qm74	8200	7	lazaroid	lazaroid	NNP
cord-015021-pol2qm74	8200	8	type	type	NN
cord-015021-pol2qm74	8200	9	effectively	effectively	RB
cord-015021-pol2qm74	8200	10	prevented	prevent	VBD
cord-015021-pol2qm74	8200	11	oxidative	oxidative	JJ
cord-015021-pol2qm74	8200	12	acinar	acinar	JJ
cord-015021-pol2qm74	8200	13	cell	cell	NN
cord-015021-pol2qm74	8200	14	damage	damage	NN
cord-015021-pol2qm74	8200	15	.	.	.
cord-015021-pol2qm74	8201	1	Stimulated	stimulated	JJ
cord-015021-pol2qm74	8201	2	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8201	3	,	,	,
cord-015021-pol2qm74	8201	4	both	both	CC
cord-015021-pol2qm74	8201	5	autologous	autologous	JJ
cord-015021-pol2qm74	8201	6	and	and	CC
cord-015021-pol2qm74	8201	7	heterologous	heterologous	JJ
cord-015021-pol2qm74	8201	8	,	,	,
cord-015021-pol2qm74	8201	9	did	do	VBD
cord-015021-pol2qm74	8201	10	not	not	RB
cord-015021-pol2qm74	8201	11	damage	damage	VB
cord-015021-pol2qm74	8201	12	healthy	healthy	JJ
cord-015021-pol2qm74	8201	13	acinar	acinar	JJ
cord-015021-pol2qm74	8201	14	cells	cell	NNS
cord-015021-pol2qm74	8201	15	but	but	CC
cord-015021-pol2qm74	8201	16	had	have	VBD
cord-015021-pol2qm74	8201	17	even	even	RB
cord-015021-pol2qm74	8201	18	protective	protective	JJ
cord-015021-pol2qm74	8201	19	effects	effect	NNS
cord-015021-pol2qm74	8201	20	.	.	.
cord-015021-pol2qm74	8202	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	8202	2	:	:	:
cord-015021-pol2qm74	8202	3	Pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8202	4	acinar	acinar	JJ
cord-015021-pol2qm74	8202	5	ceils	ceil	NNS
cord-015021-pol2qm74	8202	6	are	be	VBP
cord-015021-pol2qm74	8202	7	very	very	RB
cord-015021-pol2qm74	8202	8	susceptible	susceptible	JJ
cord-015021-pol2qm74	8202	9	to	to	IN
cord-015021-pol2qm74	8202	10	oxidative	oxidative	JJ
cord-015021-pol2qm74	8202	11	injury	injury	NN
cord-015021-pol2qm74	8202	12	.	.	.
cord-015021-pol2qm74	8203	1	A	a	DT
cord-015021-pol2qm74	8203	2	combination	combination	NN
cord-015021-pol2qm74	8203	3	of	of	IN
cord-015021-pol2qm74	8203	4	catalase	catalase	NN
cord-015021-pol2qm74	8203	5	and	and	CC
cord-015021-pol2qm74	8203	6	SOD	SOD	NNP
cord-015021-pol2qm74	8203	7	prevented	prevent	VBD
cord-015021-pol2qm74	8203	8	cell	cell	NN
cord-015021-pol2qm74	8203	9	damage	damage	NN
cord-015021-pol2qm74	8203	10	effectively	effectively	RB
cord-015021-pol2qm74	8203	11	.	.	.
cord-015021-pol2qm74	8204	1	SOD	SOD	NNP
cord-015021-pol2qm74	8204	2	when	when	WRB
cord-015021-pol2qm74	8204	3	given	give	VBN
cord-015021-pol2qm74	8204	4	alone	alone	RB
cord-015021-pol2qm74	8204	5	may	may	MD
cord-015021-pol2qm74	8204	6	rather	rather	RB
cord-015021-pol2qm74	8204	7	damage	damage	VB
cord-015021-pol2qm74	8204	8	than	than	IN
cord-015021-pol2qm74	8204	9	protect	protect	JJ
cord-015021-pol2qm74	8204	10	aelnar	aelnar	NN
cord-015021-pol2qm74	8204	11	cells	cell	NNS
cord-015021-pol2qm74	8204	12	when	when	WRB
cord-015021-pol2qm74	8204	13	H202	H202	NNP
cord-015021-pol2qm74	8204	14	is	be	VBZ
cord-015021-pol2qm74	8204	15	generated	generate	VBN
cord-015021-pol2qm74	8204	16	in	in	IN
cord-015021-pol2qm74	8204	17	concentrations	concentration	NNS
cord-015021-pol2qm74	8204	18	overwhelming	overwhelm	VBG
cord-015021-pol2qm74	8204	19	the	the	DT
cord-015021-pol2qm74	8204	20	capacity	capacity	NN
cord-015021-pol2qm74	8204	21	of	of	IN
cord-015021-pol2qm74	8204	22	endogenous	endogenous	JJ
cord-015021-pol2qm74	8204	23	catalase	catalase	NN
cord-015021-pol2qm74	8204	24	.	.	.
cord-015021-pol2qm74	8205	1	Therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8205	2	approaches	approach	NNS
cord-015021-pol2qm74	8205	3	to	to	IN
cord-015021-pol2qm74	8205	4	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8205	5	disease	disease	NN
cord-015021-pol2qm74	8205	6	using	use	VBG
cord-015021-pol2qm74	8205	7	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	8205	8	should	should	MD
cord-015021-pol2qm74	8205	9	,	,	,
cord-015021-pol2qm74	8205	10	therefore	therefore	RB
cord-015021-pol2qm74	8205	11	,	,	,
cord-015021-pol2qm74	8205	12	include	include	VBP
cord-015021-pol2qm74	8205	13	combinations	combination	NNS
cord-015021-pol2qm74	8205	14	of	of	IN
cord-015021-pol2qm74	8205	15	protective	protective	JJ
cord-015021-pol2qm74	8205	16	substances	substance	NNS
cord-015021-pol2qm74	8205	17	.	.	.
cord-015021-pol2qm74	8206	1	The	the	DT
cord-015021-pol2qm74	8206	2	lazaroids	lazaroid	NNS
cord-015021-pol2qm74	8206	3	seem	seem	VBP
cord-015021-pol2qm74	8206	4	to	to	TO
cord-015021-pol2qm74	8206	5	be	be	VB
cord-015021-pol2qm74	8206	6	candidates	candidate	NNS
cord-015021-pol2qm74	8206	7	for	for	IN
cord-015021-pol2qm74	8206	8	clinical	clinical	JJ
cord-015021-pol2qm74	8206	9	use	use	NN
cord-015021-pol2qm74	8206	10	as	as	IN
cord-015021-pol2qm74	8206	11	antioxidants	antioxidant	NNS
cord-015021-pol2qm74	8206	12	in	in	IN
cord-015021-pol2qm74	8206	13	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8206	14	.	.	.
cord-015021-pol2qm74	8207	1	The	the	DT
cord-015021-pol2qm74	8207	2	results	result	NNS
cord-015021-pol2qm74	8207	3	argue	argue	VBP
cord-015021-pol2qm74	8207	4	against	against	IN
cord-015021-pol2qm74	8207	5	direct	direct	JJ
cord-015021-pol2qm74	8207	6	toxic	toxic	JJ
cord-015021-pol2qm74	8207	7	effects	effect	NNS
cord-015021-pol2qm74	8207	8	of	of	IN
cord-015021-pol2qm74	8207	9	stimulated	stimulated	JJ
cord-015021-pol2qm74	8207	10	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8207	11	to	to	IN
cord-015021-pol2qm74	8207	12	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8207	13	acinar	acinar	NN
cord-015021-pol2qm74	8207	14	cells	cell	NNS
cord-015021-pol2qm74	8207	15	.	.	.
cord-015021-pol2qm74	8208	1	are	be	VBP
cord-015021-pol2qm74	8208	2	ch	ch	NNP
cord-015021-pol2qm74	8208	3	~	~	CD
cord-015021-pol2qm74	8208	4	act~	act~	NNP
cord-015021-pol2qm74	8209	1	z~	z~	XX
cord-015021-pol2qm74	8209	2	by	by	IN
cord-015021-pol2qm74	8209	3	the	the	DT
cord-015021-pol2qm74	8209	4	presence	presence	NN
cord-015021-pol2qm74	8209	5	of	of	IN
cord-015021-pol2qm74	8209	6	a	a	DT
cord-015021-pol2qm74	8209	7	polymicrobial	polymicrobial	JJ
cord-015021-pol2qm74	8209	8	flora	flora	NN
cord-015021-pol2qm74	8210	1	,	,	,
cord-015021-pol2qm74	8210	2	The	the	DT
cord-015021-pol2qm74	8210	3	pmtotyI~	pmtotyi~	NN
cord-015021-pol2qm74	8210	4	cffthese	cffthese	NN
cord-015021-pol2qm74	8210	5	inf	inf	NNP
cord-015021-pol2qm74	8210	6	~	~	NFP
cord-015021-pol2qm74	8210	7	ons	on	NNS
cord-015021-pol2qm74	8210	8	is	be	VBZ
cord-015021-pol2qm74	8210	9	secend~,y	secend~,y	NNP
cord-015021-pol2qm74	8210	10	bacterial	bacterial	JJ
cord-015021-pol2qm74	8210	11	pedtonitlw	pedtonitlw	NN
cord-015021-pol2qm74	8210	12	,	,	,
cord-015021-pol2qm74	8210	13	whereby	whereby	WRB
cord-015021-pol2qm74	8210	14	a	a	DT
cord-015021-pol2qm74	8210	15	pathololoeal	pathololoeal	NN
cord-015021-pol2qm74	8210	16	process	process	NN
cord-015021-pol2qm74	8210	17	in	in	IN
cord-015021-pol2qm74	8210	18	the	the	DT
cord-015021-pol2qm74	8210	19	~trointesfimd	~trointesfimd	JJS
cord-015021-pol2qm74	8210	20	tract	tract	NN
cord-015021-pol2qm74	8210	21	r	r	NN
cord-015021-pol2qm74	8210	22	~	~	NFP
cord-015021-pol2qm74	8210	23	ful~	ful~	NNP
cord-015021-pol2qm74	8210	24	in	in	IN
cord-015021-pol2qm74	8210	25	tim	tim	NNP
cord-015021-pol2qm74	8210	26	disrup	disrup	NNP
cord-015021-pol2qm74	8210	27	~	~	NFP
cord-015021-pol2qm74	8210	28	on	on	IN
cord-015021-pol2qm74	8210	29	ofi~	ofi~	CD
cord-015021-pol2qm74	8210	30	inteffrlty	inteffrlty	NN
cord-015021-pol2qm74	8210	31	and	and	CC
cord-015021-pol2qm74	8210	32	¢ollseqtlent	¢ollseqtlent	NN
cord-015021-pol2qm74	8210	33	sptl]nge	sptl]nge	NNP
cord-015021-pol2qm74	8210	34	of	of	IN
cord-015021-pol2qm74	8210	35	inte~.i	inte~.i	NNP
cord-015021-pol2qm74	8210	36	,	,	,
cord-015021-pol2qm74	8210	37	o~.l	o~.l	IN
cord-015021-pol2qm74	8210	38	gontents	gontent	NNS
cord-015021-pol2qm74	8210	39	into	into	IN
cord-015021-pol2qm74	8210	40	the	the	DT
cord-015021-pol2qm74	8210	41	peritoneal	peritoneal	NN
cord-015021-pol2qm74	8210	42	c	c	NN
cord-015021-pol2qm74	8210	43	~	~	NFP
cord-015021-pol2qm74	8210	44	iry	iry	NNP
cord-015021-pol2qm74	8210	45	.	.	.
cord-015021-pol2qm74	8211	1	The	the	DT
cord-015021-pol2qm74	8211	2	ensuing	ensue	VBG
cord-015021-pol2qm74	8211	3	infection	infection	NN
cord-015021-pol2qm74	8211	4	invariably	invariably	RB
cord-015021-pol2qm74	8211	5	contains	contain	VBZ
cord-015021-pol2qm74	8211	6	a	a	DT
cord-015021-pol2qm74	8211	7	mixtm~	mixtm~	NNP
cord-015021-pol2qm74	8211	8	of	of	IN
cord-015021-pol2qm74	8211	9	gt	gt	NNP
cord-015021-pol2qm74	8211	10	~	~	NNP
cord-015021-pol2qm74	8211	11	m	m	CD
cord-015021-pol2qm74	8211	12	negative	negative	JJ
cord-015021-pol2qm74	8211	13	enteric	enteric	JJ
cord-015021-pol2qm74	8211	14	bacilli	bacilli	NN
cord-015021-pol2qm74	8211	15	,	,	,
cord-015021-pol2qm74	8211	16	gram	gram	NN
cord-015021-pol2qm74	8211	17	positive	positive	JJ
cord-015021-pol2qm74	8211	18	b	b	NNP
cord-015021-pol2qm74	8211	19	~	~	NFP
cord-015021-pol2qm74	8211	20	eria	eria	NNP
cord-015021-pol2qm74	8211	21	and	and	CC
cord-015021-pol2qm74	8211	22	anaerobe	anaerobe	NNP
cord-015021-pol2qm74	8211	23	&	&	CC
cord-015021-pol2qm74	8211	24	Experimental	Experimental	NNP
cord-015021-pol2qm74	8211	25	and	and	CC
cord-015021-pol2qm74	8211	26	clinical	clinical	JJ
cord-015021-pol2qm74	8211	27	=	=	NN
cord-015021-pol2qm74	8212	1	t	t	NNP
cord-015021-pol2qm74	8213	1	~ies	~ie	NNS
cord-015021-pol2qm74	8213	2	have	have	VBP
cord-015021-pol2qm74	8213	3	de	de	NNP
cord-015021-pol2qm74	8213	4	~	~	CD
cord-015021-pol2qm74	8213	5	ed	ed	NN
cord-015021-pol2qm74	8213	6	the	the	DT
cord-015021-pol2qm74	8213	7	eantrlbution	eantrlbution	NN
cord-015021-pol2qm74	8213	8	of	of	IN
cord-015021-pol2qm74	8213	9	each	each	DT
cord-015021-pol2qm74	8213	10	of	of	IN
cord-015021-pol2qm74	8213	11	th¢~	th¢~	NN
cord-015021-pol2qm74	8213	12	components	component	NNS
cord-015021-pol2qm74	8213	13	to	to	IN
cord-015021-pol2qm74	8213	14	ti~	ti~	JJ
cord-015021-pol2qm74	8213	15	ovemU	ovemu	JJ
cord-015021-pol2qm74	8213	16	virulence	virulence	NN
cord-015021-pol2qm74	8213	17	of	of	IN
cord-015021-pol2qm74	8213	18	these	these	DT
cord-015021-pol2qm74	8213	19	in	in	IN
cord-015021-pol2qm74	8213	20	~	~	CD
cord-015021-pol2qm74	8213	21	ons	on	NNS
cord-015021-pol2qm74	8213	22	,	,	,
cord-015021-pol2qm74	8213	23	Gram	Gram	NNP
cord-015021-pol2qm74	8213	24	negative	negative	JJ
cord-015021-pol2qm74	8213	25	enteri~	enteri~	NNS
cord-015021-pol2qm74	8213	26	such	such	JJ
cord-015021-pol2qm74	8213	27	as	as	IN
cord-015021-pol2qm74	8213	28	F.veher	F.veher	NNP
cord-015021-pol2qm74	8214	1	~chla	~chla	NFP
cord-015021-pol2qm74	8214	2	coil	coil	NN
cord-015021-pol2qm74	8214	3	ere	ere	VBP
cord-015021-pol2qm74	8214	4	endowed	endow	VBN
cord-015021-pol2qm74	8214	5	with	with	IN
cord-015021-pol2qm74	8214	6	a	a	DT
cord-015021-pol2qm74	8214	7	virulent	virulent	JJ
cord-015021-pol2qm74	8214	8	l	l	NN
cord-015021-pol2qm74	8214	9	~	~	NFP
cord-015021-pol2qm74	8214	10	l	l	NN
cord-015021-pol2qm74	8214	11	~	~	CD
cord-015021-pol2qm74	8214	12	x	x	.
cord-015021-pol2qm74	8215	1	~lyse	~lyse	XX
cord-015021-pol2qm74	8216	1	~haride	~haride	NNP
cord-015021-pol2qm74	8216	2	ptill~	ptill~	XX
cord-015021-pol2qm74	8217	1	ly	ly	NNP
cord-015021-pol2qm74	8217	2	t	t	NNP
cord-015021-pol2qm74	8217	3	~	~	CD
cord-015021-pol2qm74	8217	4	sponsible	sponsible	NNP
cord-015021-pol2qm74	8217	5	for	for	IN
cord-015021-pol2qm74	8217	6	lethality	lethality	NN
cord-015021-pol2qm74	8217	7	,	,	,
cord-015021-pol2qm74	8218	1	By	by	IN
cord-015021-pol2qm74	8218	2	contrast	contrast	NN
cord-015021-pol2qm74	8218	3	,	,	,
cord-015021-pol2qm74	8218	4	Bacteroldes	Bacteroldes	NNP
cord-015021-pol2qm74	8218	5	sl	sl	NNP
cord-015021-pol2qm74	8218	6	~	~	NFP
cord-015021-pol2qm74	8218	7	cles	cles	NNP
cord-015021-pol2qm74	8218	8	,	,	,
cord-015021-pol2qm74	8218	9	which	which	WDT
cord-015021-pol2qm74	8218	10	rarely	rarely	RB
cord-015021-pol2qm74	8218	11	c	c	NNP
cord-015021-pol2qm74	8218	12	~	~	NFP
cord-015021-pol2qm74	8218	13	se	se	FW
cord-015021-pol2qm74	8218	14	death	death	NN
cord-015021-pol2qm74	8218	15	,	,	,
cord-015021-pol2qm74	8218	16	prornot~	prornot~	NNP
cord-015021-pol2qm74	8218	17	abscess	abscess	NN
cord-015021-pol2qm74	8218	18	fOnllation	fOnllation	NNP
cord-015021-pol2qm74	8218	19	,	,	,
cord-015021-pol2qm74	8218	20	A	a	DT
cord-015021-pol2qm74	8218	21	uniqm~	uniqm~	NN
cord-015021-pol2qm74	8218	22	capsul~	capsul~	JJ
cord-015021-pol2qm74	8218	23	polyseccluu'ide	polyseccluu'ide	NN
cord-015021-pol2qm74	8218	24	,	,	,
cord-015021-pol2qm74	8218	25	particularly	particularly	RB
cord-015021-pol2qm74	8218	26	on	on	IN
cord-015021-pol2qm74	8218	27	B.j	B.j	NNP
cord-015021-pol2qm74	8218	28	~	~	CD
cord-015021-pol2qm74	8218	29	ogilJs	ogiljs	CD
cord-015021-pol2qm74	8218	30	slrai~	slrai~	NNP
cord-015021-pol2qm74	8218	31	,	,	,
cord-015021-pol2qm74	8218	32	oontributes	oontribute	NNS
cord-015021-pol2qm74	8218	33	to	to	IN
cord-015021-pol2qm74	8218	34	tJtis	tJtis	NNP
cord-015021-pol2qm74	8218	35	erect	erect	VB
cord-015021-pol2qm74	8218	36	,	,	,
cord-015021-pol2qm74	8218	37	Several	several	JJ
cord-015021-pol2qm74	8218	38	mecltanims	mecltanim	NNS
cord-015021-pol2qm74	8218	39	have	have	VBP
cord-015021-pol2qm74	8218	40	bccn	bccn	NNP
cord-015021-pol2qm74	8218	41	pml~	pml~	XX
cord-015021-pol2qm74	8219	1	ed	ed	NNP
cord-015021-pol2qm74	8219	2	whereby	whereby	WRB
cord-015021-pol2qm74	8219	3	or~	or~	NNP
cord-015021-pol2qm74	8219	4	microorganism	microorganism	NNP
cord-015021-pol2qm74	8219	5	mi	mi	NNP
cord-015021-pol2qm74	8219	6	~	~	NFP
cord-015021-pol2qm74	8219	7	t	t	XX
cord-015021-pol2qm74	8219	8	interact	interact	VB
cord-015021-pol2qm74	8219	9	with	with	IN
cord-015021-pol2qm74	8219	10	its	-PRON-	PRP$
cord-015021-pol2qm74	8219	11	microbial	microbial	JJ
cord-015021-pol2qm74	8219	12	~net	~net	NNP
cord-015021-pol2qm74	8219	13	to	to	TO
cord-015021-pol2qm74	8219	14	augment	augment	VB
cord-015021-pol2qm74	8219	15	the	the	DT
cord-015021-pol2qm74	8219	16	overall	overall	JJ
cord-015021-pol2qm74	8219	17	virulence	virulence	NN
cord-015021-pol2qm74	8219	18	of	of	IN
cord-015021-pol2qm74	8219	19	a	a	DT
cord-015021-pol2qm74	8219	20	r	r	NN
cord-015021-pol2qm74	8219	21	~	~	NFP
cord-015021-pol2qm74	8219	22	xed	xed	NN
cord-015021-pol2qm74	8219	23	im	im	UH
cord-015021-pol2qm74	8219	24	~	~	NFP
cord-015021-pol2qm74	8219	25	edan	edan	NNP
cord-015021-pol2qm74	8219	26	.	.	.
cord-015021-pol2qm74	8220	1	These	these	DT
cord-015021-pol2qm74	8220	2	include	include	VBP
cord-015021-pol2qm74	8220	3	:	:	:
cord-015021-pol2qm74	8220	4	l	l	NN
cord-015021-pol2qm74	8220	5	)	)	-RRB-
cord-015021-pol2qm74	8220	6	provision	provision	NN
cord-015021-pol2qm74	8220	7	of	of	IN
cord-015021-pol2qm74	8220	8	nutrients	nutrient	NNS
cord-015021-pol2qm74	8220	9	by	by	IN
cord-015021-pol2qm74	8220	10	one	one	CD
cord-015021-pol2qm74	8220	11	apexes	apex	NNS
cord-015021-pol2qm74	8220	12	which	which	WDT
cord-015021-pol2qm74	8220	13	stimulates	stimulate	VBZ
cord-015021-pol2qm74	8220	14	the	the	DT
cord-015021-pol2qm74	8220	15	growth	growth	NN
cord-015021-pol2qm74	8220	16	of	of	IN
cord-015021-pol2qm74	8220	17	its	-PRON-	PRP$
cord-015021-pol2qm74	8220	18	~opathoge	~opathoge	NNP
cord-015021-pol2qm74	8220	19	&	&	CC
cord-015021-pol2qm74	8220	20	2	2	CD
cord-015021-pol2qm74	8220	21	)	)	-RRB-
cord-015021-pol2qm74	8220	22	inhibition	inhibition	NN
cord-015021-pol2qm74	8220	23	of	of	IN
cord-015021-pol2qm74	8220	24	host	host	NN
cord-015021-pol2qm74	8220	25	deletes	delete	VBZ
cord-015021-pol2qm74	8220	26	by	by	IN
cord-015021-pol2qm74	8220	27	one	one	CD
cord-015021-pol2qm74	8220	28	of	of	IN
cord-015021-pol2qm74	8220	29	the	the	DT
cord-015021-pol2qm74	8220	30	migroorganisms	migroorganism	NNS
cord-015021-pol2qm74	8220	31	so	so	IN
cord-015021-pol2qm74	8220	32	that	that	IN
cord-015021-pol2qm74	8220	33	the	the	DT
cord-015021-pol2qm74	8220	34	other	other	JJ
cord-015021-pol2qm74	8220	35	microbes	microbe	NNS
cord-015021-pol2qm74	8220	36	might	may	MD
cord-015021-pol2qm74	8220	37	persist	persist	VB
cord-015021-pol2qm74	8220	38	and	and	CC
cord-015021-pol2qm74	8220	39	exert	exert	VB
cord-015021-pol2qm74	8220	40	their	-PRON-	PRP$
cord-015021-pol2qm74	8220	41	virulence	virulence	NN
cord-015021-pol2qm74	8220	42	,	,	,
cord-015021-pol2qm74	8220	43	3	3	CD
cord-015021-pol2qm74	8220	44	)	)	-RRB-
cord-015021-pol2qm74	8220	45	the	the	DT
cord-015021-pol2qm74	8220	46	trant~	trant~	NNP
cord-015021-pol2qm74	8220	47	of	of	IN
cord-015021-pol2qm74	8220	48	viM.	viM.	NNP
cord-015021-pol2qm74	8220	49	©	©	NNP
cord-015021-pol2qm74	8220	50	n	n	NN
cord-015021-pol2qm74	8220	51	~	~	NFP
cord-015021-pol2qm74	8220	52	e	e	LS
cord-015021-pol2qm74	8220	53	traits	trait	NNS
cord-015021-pol2qm74	8220	54	between	between	IN
cord-015021-pol2qm74	8220	55	~renr	~renr	NNP
cord-015021-pol2qm74	8220	56	~	~	NFP
cord-015021-pol2qm74	8220	57	a	a	LS
cord-015021-pol2qm74	8220	58	.	.	.
cord-015021-pol2qm74	8220	59	,dsms	,dsms	,
cord-015021-pol2qm74	8220	60	and	and	CC
cord-015021-pol2qm74	8220	61	4	4	LS
cord-015021-pol2qm74	8220	62	)	)	-RRB-
cord-015021-pol2qm74	8221	1	the	the	DT
cord-015021-pol2qm74	8221	2	~.mizatian	~.mizatian	CD
cord-015021-pol2qm74	8221	3	d	d	XX
cord-015021-pol2qm74	8222	1	the	the	DT
cord-015021-pol2qm74	8222	2	mi	mi	NNP
cord-015021-pol2qm74	8222	3	~	~	NNP
cord-015021-pol2qm74	8222	4	oe	oe	NNP
cord-015021-pol2qm74	8222	5	~	~	NFP
cord-015021-pol2qm74	8222	6	vironmental	vironmental	NNP
cord-015021-pol2qm74	8222	7	con	con	NNP
cord-015021-pol2qm74	8222	8	~	~	CD
cord-015021-pol2qm74	8222	9	tion$	tion$	NNP
cord-015021-pol2qm74	8222	10	by	by	IN
cord-015021-pol2qm74	8222	11	one	one	CD
cord-015021-pol2qm74	8222	12	d	d	NN
cord-015021-pol2qm74	8223	1	the	the	DT
cord-015021-pol2qm74	8223	2	baetez'isl	baetez'isl	NNP
cord-015021-pol2qm74	8223	3	pa	pa	NNP
cord-015021-pol2qm74	8223	4	#	#	NNP
cord-015021-pol2qm74	8223	5	,	,	,
cord-015021-pol2qm74	8223	6	so	so	IN
cord-015021-pol2qm74	8223	7	that	that	IN
cord-015021-pol2qm74	8223	8	the	the	DT
cord-015021-pol2qm74	8223	9	other	other	JJ
cord-015021-pol2qm74	8223	10	might	may	MD
cord-015021-pol2qm74	8223	11	persist	persist	VB
cord-015021-pol2qm74	8223	12	.	.	.
cord-015021-pol2qm74	8224	1	Exampl~	Exampl~	``
cord-015021-pol2qm74	8224	2	for	for	IN
cord-015021-pol2qm74	8224	3	each	each	DT
cord-015021-pol2qm74	8224	4	of	of	IN
cord-015021-pol2qm74	8224	5	these	these	DT
cord-015021-pol2qm74	8224	6	m	m	NN
cord-015021-pol2qm74	8224	7	~	~	NFP
cord-015021-pol2qm74	8224	8	banisms	banism	NNS
cord-015021-pol2qm74	8224	9	Imv~	imv~	RB
cord-015021-pol2qm74	8224	10	been	be	VBN
cord-015021-pol2qm74	8224	11	provided	provide	VBN
cord-015021-pol2qm74	8224	12	by	by	IN
cord-015021-pol2qm74	8224	13	experimental	experimental	JJ
cord-015021-pol2qm74	8224	14	ttudies	ttudie	NNS
cord-015021-pol2qm74	8225	1	i	i	PRP
cord-015021-pol2qm74	8225	2	~	~	NFP
cord-015021-pol2qm74	8225	3	stigating	stigate	VBG
cord-015021-pol2qm74	8225	4	E.co!l-	e.co!l-	NN
cord-015021-pol2qm74	8226	1	B.p	B.p	NNP
cord-015021-pol2qm74	8227	1	~flls	~flls	NNP
cord-015021-pol2qm74	8227	2	synergistic	synergistic	JJ
cord-015021-pol2qm74	8227	3	in	in	IN
cord-015021-pol2qm74	8227	4	~	~	NFP
cord-015021-pol2qm74	8227	5	ra	ra	NNP
cord-015021-pol2qm74	8227	6	~	~	NNP
cord-015021-pol2qm74	8227	7	ons	on	NNS
cord-015021-pol2qm74	8227	8	.	.	.
cord-015021-pol2qm74	8228	1	Byproducts	byproduct	NNS
cord-015021-pol2qm74	8228	2	ofg.coli	ofg.coli	NNP
cord-015021-pol2qm74	8228	3	metabolim	metabolim	NN
cord-015021-pol2qm74	8228	4	l~¢ovide	l~¢ovide	NNP
cord-015021-pol2qm74	8228	5	essential	essential	JJ
cord-015021-pol2qm74	8228	6	short	short	JJ
cord-015021-pol2qm74	8228	7	ebath	ebath	NNP
cord-015021-pol2qm74	8228	8	fatty	fatty	JJ
cord-015021-pol2qm74	8228	9	acids	acid	NNS
cord-015021-pol2qm74	8229	1	£	£	$
cord-015021-pol2qm74	8229	2	~	~	NFP
cord-015021-pol2qm74	8229	3	optimal	optimal	JJ
cord-015021-pol2qm74	8229	4	B	b	NN
cord-015021-pol2qm74	8229	5	,	,	,
cord-015021-pol2qm74	8230	1	frosili~	frosili~	NNP
cord-015021-pol2qm74	8230	2	ga'owth	ga'owth	NNP
cord-015021-pol2qm74	8230	3	.	.	.
cord-015021-pol2qm74	8231	1	Fm	Fm	NNP
cord-015021-pol2qm74	8231	2	-	-	HYPH
cord-015021-pol2qm74	8231	3	ther	ther	NNP
cord-015021-pol2qm74	8231	4	,	,	,
cord-015021-pol2qm74	8231	5	oxygen	oxygen	NN
cord-015021-pol2qm74	8231	6	¢ons	¢on	NNS
cord-015021-pol2qm74	8232	1	~tmption	~tmption	NNP
cord-015021-pol2qm74	8232	2	by	by	IN
cord-015021-pol2qm74	8232	3	Kcelt	Kcelt	NNP
cord-015021-pol2qm74	8232	4	lowers	lower	VBZ
cord-015021-pol2qm74	8232	5	oxygen	oxygen	NN
cord-015021-pol2qm74	8232	6	tension	tension	NN
cord-015021-pol2qm74	8232	7	end	end	NN
cord-015021-pol2qm74	8232	8	redox	redox	NN
cord-015021-pol2qm74	8232	9	potantial	potantial	NN
cord-015021-pol2qm74	8232	10	to	to	IN
cord-015021-pol2qm74	8232	11	levels	level	NNS
cord-015021-pol2qm74	8232	12	eomlucive	eomlucive	NNS
cord-015021-pol2qm74	8232	13	to	to	IN
cord-015021-pol2qm74	8232	14	B#a#lts	B#a#lts	NNP
cord-015021-pol2qm74	8232	15	gro	gro	NNP
cord-015021-pol2qm74	8232	16	~	~	NFP
cord-015021-pol2qm74	8232	17	h	h	NN
cord-015021-pol2qm74	8232	18	.	.	.
cord-015021-pol2qm74	8233	1	Coawr	Coawr	NNP
cord-015021-pol2qm74	8233	2	~	~	NFP
cord-015021-pol2qm74	8233	3	ely	ely	NNP
cord-015021-pol2qm74	8233	4	,	,	,
cord-015021-pol2qm74	8233	5	B,~agtlis	B,~agtlis	NNP
cord-015021-pol2qm74	8233	6	rolea~	rolea~	NNP
cord-015021-pol2qm74	8234	1	s	s	POS
cord-015021-pol2qm74	8234	2	proteases	protease	NNS
cord-015021-pol2qm74	8234	3	and	and	CC
cord-015021-pol2qm74	8234	4	fatty	fatty	JJ
cord-015021-pol2qm74	8234	5	acids	acid	NNS
cord-015021-pol2qm74	8235	1	wl~¢h	wl~¢h	NNP
cord-015021-pol2qm74	8235	2	impair	impair	VB
cord-015021-pol2qm74	8235	3	pl'tsgocy~¢	pl'tsgocy~¢	NN
cord-015021-pol2qm74	8236	1	~lt	~lt	NNP
cord-015021-pol2qm74	8236	2	Rmctlon	Rmctlon	NNP
cord-015021-pol2qm74	8236	3	tnd	tnd	NN
cord-015021-pol2qm74	8236	4	permit	permit	VBP
cord-015021-pol2qm74	8236	5	F-	f-	CD
cord-015021-pol2qm74	8236	6	..	..	.
cord-015021-pol2qm74	8237	1	¢oli	¢oli	CD
cord-015021-pol2qm74	8238	1	proliferation	proliferation	NN
cord-015021-pol2qm74	8238	2	and	and	CC
cord-015021-pol2qm74	8238	3	expression	expression	NN
cord-015021-pol2qm74	8238	4	of	of	IN
cord-015021-pol2qm74	8238	5	its	-PRON-	PRP$
cord-015021-pol2qm74	8238	6	intrinsic	intrinsic	JJ
cord-015021-pol2qm74	8238	7	virulent	virulent	NN
cord-015021-pol2qm74	8238	8	.	.	.
cord-015021-pol2qm74	8239	1	In	in	IN
cord-015021-pol2qm74	8239	2	summaxy	summaxy	NNS
cord-015021-pol2qm74	8239	3	,	,	,
cord-015021-pol2qm74	8239	4	interactions	interaction	NNS
cord-015021-pol2qm74	8239	5	among	among	IN
cord-015021-pol2qm74	8239	6	the	the	DT
cord-015021-pol2qm74	8239	7	separate	separate	JJ
cord-015021-pol2qm74	8239	8	microbial	microbial	JJ
cord-015021-pol2qm74	8239	9	cemponents	cemponent	NNS
cord-015021-pol2qm74	8239	10	of	of	IN
cord-015021-pol2qm74	8239	11	mixed	mixed	JJ
cord-015021-pol2qm74	8239	12	infections	infection	NNS
cord-015021-pol2qm74	8239	13	heighten	heighten	VBP
cord-015021-pol2qm74	8239	14	the	the	DT
cord-015021-pol2qm74	8239	15	overall	overall	JJ
cord-015021-pol2qm74	8239	16	virttienee	virttienee	NN
cord-015021-pol2qm74	8239	17	of	of	IN
cord-015021-pol2qm74	8239	18	these	these	DT
cord-015021-pol2qm74	8239	19	lafectiot~	lafectiot~	NNP
cord-015021-pol2qm74	8239	20	,	,	,
cord-015021-pol2qm74	8239	21	This	this	DT
cord-015021-pol2qm74	8239	22	knowledge	knowledge	NN
cord-015021-pol2qm74	8239	23	provides	provide	VBZ
cord-015021-pol2qm74	8239	24	~r	~r	XX
cord-015021-pol2qm74	8239	25	rationale	rationale	NN
cord-015021-pol2qm74	8239	26	for	for	IN
cord-015021-pol2qm74	8239	27	targetting	targette	VBG
cord-015021-pol2qm74	8239	28	of	of	IN
cord-015021-pol2qm74	8239	29	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	8239	30	therapy	therapy	NN
cord-015021-pol2qm74	8239	31	against	against	IN
cord-015021-pol2qm74	8239	32	the	the	DT
cord-015021-pol2qm74	8239	33	knowa	knowa	NNP
cord-015021-pol2qm74	8239	34	eantributors	eantributor	NNS
cord-015021-pol2qm74	8239	35	of	of	IN
cord-015021-pol2qm74	8239	36	these	these	DT
cord-015021-pol2qm74	8239	37	synergistic	synergistic	JJ
cord-015021-pol2qm74	8239	38	pro~¢sses	pro~¢sse	NNS
cord-015021-pol2qm74	8239	39	,	,	,
cord-015021-pol2qm74	8239	40	Intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8239	41	abscess	abscess	NN
cord-015021-pol2qm74	8239	42	formation	formation	NN
cord-015021-pol2qm74	8239	43	and	and	CC
cord-015021-pol2qm74	8239	44	the	the	DT
cord-015021-pol2qm74	8239	45	macrophage	macrophage	NN
cord-015021-pol2qm74	8239	46	William	William	NNP
cord-015021-pol2qm74	8239	47	G.	G.	NNP
cord-015021-pol2qm74	8239	48	Cheadle	Cheadle	NNP
cord-015021-pol2qm74	8239	49	,	,	,
cord-015021-pol2qm74	8239	50	M.D.	M.D.	NNP
cord-015021-pol2qm74	8239	51	,	,	,
cord-015021-pol2qm74	8239	52	Department	Department	NNP
cord-015021-pol2qm74	8239	53	of	of	IN
cord-015021-pol2qm74	8239	54	Surgery	Surgery	NNP
cord-015021-pol2qm74	8239	55	,	,	,
cord-015021-pol2qm74	8239	56	University	University	NNP
cord-015021-pol2qm74	8239	57	of	of	IN
cord-015021-pol2qm74	8239	58	Louisville	Louisville	NNP
cord-015021-pol2qm74	8239	59	School	School	NNP
cord-015021-pol2qm74	8239	60	of	of	IN
cord-015021-pol2qm74	8239	61	Medicine	Medicine	NNP
cord-015021-pol2qm74	8239	62	,	,	,
cord-015021-pol2qm74	8239	63	Louisville	Louisville	NNP
cord-015021-pol2qm74	8239	64	,	,	,
cord-015021-pol2qm74	8240	1	KY	KY	NNP
cord-015021-pol2qm74	8240	2	40292	40292	CD
cord-015021-pol2qm74	8240	3	Inflammation	inflammation	NN
cord-015021-pol2qm74	8240	4	of	of	IN
cord-015021-pol2qm74	8240	5	the	the	DT
cord-015021-pol2qm74	8240	6	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8240	7	cavity	cavity	NN
cord-015021-pol2qm74	8240	8	following	follow	VBG
cord-015021-pol2qm74	8240	9	bacterial	bacterial	JJ
cord-015021-pol2qm74	8240	10	contamination	contamination	NN
cord-015021-pol2qm74	8240	11	has	have	VBZ
cord-015021-pol2qm74	8240	12	been	be	VBN
cord-015021-pol2qm74	8240	13	classified	classify	VBN
cord-015021-pol2qm74	8240	14	into	into	IN
cord-015021-pol2qm74	8240	15	primary	primary	JJ
cord-015021-pol2qm74	8240	16	,	,	,
cord-015021-pol2qm74	8240	17	secondary	secondary	JJ
cord-015021-pol2qm74	8240	18	and	and	CC
cord-015021-pol2qm74	8240	19	tertiary	tertiary	JJ
cord-015021-pol2qm74	8240	20	,	,	,
cord-015021-pol2qm74	8240	21	the	the	DT
cord-015021-pol2qm74	8240	22	last	last	JJ
cord-015021-pol2qm74	8240	23	two	two	CD
cord-015021-pol2qm74	8240	24	relating	relate	VBG
cord-015021-pol2qm74	8240	25	to	to	IN
cord-015021-pol2qm74	8240	26	bacteria	bacteria	NNS
cord-015021-pol2qm74	8240	27	originating	originate	VBG
cord-015021-pol2qm74	8240	28	from	from	IN
cord-015021-pol2qm74	8240	29	the	the	DT
cord-015021-pol2qm74	8240	30	gastrointestinal	gastrointestinal	JJ
cord-015021-pol2qm74	8240	31	lumen	lumen	NN
cord-015021-pol2qm74	8240	32	.	.	.
cord-015021-pol2qm74	8241	1	The	the	DT
cord-015021-pol2qm74	8241	2	natural	natural	JJ
cord-015021-pol2qm74	8241	3	history	history	NN
cord-015021-pol2qm74	8241	4	of	of	IN
cord-015021-pol2qm74	8241	5	such	such	JJ
cord-015021-pol2qm74	8241	6	infection	infection	NN
cord-015021-pol2qm74	8241	7	is	be	VBZ
cord-015021-pol2qm74	8241	8	either	either	DT
cord-015021-pol2qm74	8241	9	resolution	resolution	NN
cord-015021-pol2qm74	8241	10	without	without	IN
cord-015021-pol2qm74	8241	11	clinical	clinical	JJ
cord-015021-pol2qm74	8241	12	sequelae	sequela	NNS
cord-015021-pol2qm74	8241	13	,	,	,
cord-015021-pol2qm74	8241	14	which	which	WDT
cord-015021-pol2qm74	8241	15	is	be	VBZ
cord-015021-pol2qm74	8241	16	uncommon	uncommon	JJ
cord-015021-pol2qm74	8241	17	,	,	,
cord-015021-pol2qm74	8241	18	abscess	abscess	NN
cord-015021-pol2qm74	8241	19	formation	formation	NN
cord-015021-pol2qm74	8241	20	,	,	,
cord-015021-pol2qm74	8241	21	or	or	CC
cord-015021-pol2qm74	8241	22	generalized	generalized	JJ
cord-015021-pol2qm74	8241	23	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8241	24	,	,	,
cord-015021-pol2qm74	8241	25	which	which	WDT
cord-015021-pol2qm74	8241	26	occurs	occur	VBZ
cord-015021-pol2qm74	8241	27	as	as	IN
cord-015021-pol2qm74	8241	28	a	a	DT
cord-015021-pol2qm74	8241	29	result	result	NN
cord-015021-pol2qm74	8241	30	of	of	IN
cord-015021-pol2qm74	8241	31	failure	failure	NN
cord-015021-pol2qm74	8241	32	of	of	IN
cord-015021-pol2qm74	8241	33	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8241	34	host	host	NN
cord-015021-pol2qm74	8241	35	defenses	defense	NNS
cord-015021-pol2qm74	8241	36	.	.	.
cord-015021-pol2qm74	8242	1	Early	early	JJ
cord-015021-pol2qm74	8242	2	clearance	clearance	NN
cord-015021-pol2qm74	8242	3	of	of	IN
cord-015021-pol2qm74	8242	4	microorganisms	microorganism	NNS
cord-015021-pol2qm74	8242	5	by	by	IN
cord-015021-pol2qm74	8242	6	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8242	7	fluid	fluid	JJ
cord-015021-pol2qm74	8242	8	circulation	circulation	NN
cord-015021-pol2qm74	8242	9	and	and	CC
cord-015021-pol2qm74	8242	10	filtration	filtration	NN
cord-015021-pol2qm74	8242	11	througti	througti	NNP
cord-015021-pol2qm74	8242	12	subdiaphragmatic	subdiaphragmatic	NNP
cord-015021-pol2qm74	8242	13	lymphatics	lymphatic	NNS
cord-015021-pol2qm74	8242	14	into	into	IN
cord-015021-pol2qm74	8242	15	the	the	DT
cord-015021-pol2qm74	8242	16	thoracic	thoracic	JJ
cord-015021-pol2qm74	8242	17	duct	duct	NN
cord-015021-pol2qm74	8242	18	and	and	CC
cord-015021-pol2qm74	8242	19	systemic	systemic	JJ
cord-015021-pol2qm74	8242	20	circulation	circulation	NN
cord-015021-pol2qm74	8242	21	occurs	occur	VBZ
cord-015021-pol2qm74	8242	22	as	as	RB
cord-015021-pol2qm74	8242	23	well	well	RB
cord-015021-pol2qm74	8242	24	.	.	.
cord-015021-pol2qm74	8243	1	Simultaneously	simultaneously	RB
cord-015021-pol2qm74	8243	2	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8243	3	macrophages	macrophage	NNS
cord-015021-pol2qm74	8243	4	and	and	CC
cord-015021-pol2qm74	8243	5	the	the	DT
cord-015021-pol2qm74	8243	6	omentum	omentum	NN
cord-015021-pol2qm74	8243	7	approach	approach	NN
cord-015021-pol2qm74	8243	8	the	the	DT
cord-015021-pol2qm74	8243	9	area	area	NN
cord-015021-pol2qm74	8243	10	of	of	IN
cord-015021-pol2qm74	8243	11	inflammation	inflammation	NN
cord-015021-pol2qm74	8243	12	and	and	CC
cord-015021-pol2qm74	8243	13	lead	lead	NN
cord-015021-pol2qm74	8243	14	to	to	IN
cord-015021-pol2qm74	8243	15	neutrophil	neutrophil	NN
cord-015021-pol2qm74	8243	16	influx	influx	NN
cord-015021-pol2qm74	8243	17	and	and	CC
cord-015021-pol2qm74	8243	18	abscess	abscess	NN
cord-015021-pol2qm74	8243	19	formation	formation	NN
cord-015021-pol2qm74	8243	20	adjacent	adjacent	JJ
cord-015021-pol2qm74	8243	21	to	to	IN
cord-015021-pol2qm74	8243	22	the	the	DT
cord-015021-pol2qm74	8243	23	affected	affected	JJ
cord-015021-pol2qm74	8243	24	viscus	viscus	NN
cord-015021-pol2qm74	8243	25	.	.	.
cord-015021-pol2qm74	8244	1	We	-PRON-	PRP
cord-015021-pol2qm74	8244	2	have	have	VBP
cord-015021-pol2qm74	8244	3	found	find	VBN
cord-015021-pol2qm74	8244	4	a	a	DT
cord-015021-pol2qm74	8244	5	shift	shift	NN
cord-015021-pol2qm74	8244	6	in	in	IN
cord-015021-pol2qm74	8244	7	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8244	8	macrophage	macrophage	NN
cord-015021-pol2qm74	8244	9	function	function	NN
cord-015021-pol2qm74	8244	10	from	from	IN
cord-015021-pol2qm74	8244	11	antigen	antigen	NN
cord-015021-pol2qm74	8244	12	presentation	presentation	NN
cord-015021-pol2qm74	8244	13	to	to	IN
cord-015021-pol2qm74	8244	14	proinflarnmatory	proinflarnmatory	JJ
cord-015021-pol2qm74	8244	15	cytokine	cytokine	JJ
cord-015021-pol2qm74	8244	16	production	production	NN
cord-015021-pol2qm74	8244	17	that	that	WDT
cord-015021-pol2qm74	8244	18	occurs	occur	VBZ
cord-015021-pol2qm74	8244	19	early	early	RB
cord-015021-pol2qm74	8244	20	after	after	IN
cord-015021-pol2qm74	8244	21	experimental	experimental	JJ
cord-015021-pol2qm74	8244	22	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8244	23	produced	produce	VBN
cord-015021-pol2qm74	8244	24	by	by	IN
cord-015021-pol2qm74	8244	25	cecal	cecal	JJ
cord-015021-pol2qm74	8244	26	ligation	ligation	NN
cord-015021-pol2qm74	8244	27	and	and	CC
cord-015021-pol2qm74	8244	28	puncture	puncture	NN
cord-015021-pol2qm74	8244	29	.	.	.
cord-015021-pol2qm74	8245	1	This	this	DT
cord-015021-pol2qm74	8245	2	is	be	VBZ
cord-015021-pol2qm74	8245	3	also	also	RB
cord-015021-pol2qm74	8245	4	reflected	reflect	VBN
cord-015021-pol2qm74	8245	5	by	by	IN
cord-015021-pol2qm74	8245	6	reduced	reduce	VBN
cord-015021-pol2qm74	8245	7	class	class	NN
cord-015021-pol2qm74	8245	8	II	II	NNP
cord-015021-pol2qm74	8245	9	histocompatibility	histocompatibility	NN
cord-015021-pol2qm74	8245	10	antigen	antigen	NN
cord-015021-pol2qm74	8245	11	expression	expression	NN
cord-015021-pol2qm74	8245	12	on	on	IN
cord-015021-pol2qm74	8245	13	peripheral	peripheral	JJ
cord-015021-pol2qm74	8245	14	blood	blood	NN
cord-015021-pol2qm74	8245	15	mononuclear	mononuclear	NN
cord-015021-pol2qm74	8245	16	cells	cell	NNS
cord-015021-pol2qm74	8245	17	and	and	CC
cord-015021-pol2qm74	8245	18	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8245	19	macrophages	macrophage	NNS
cord-015021-pol2qm74	8245	20	.	.	.
cord-015021-pol2qm74	8246	1	This	this	DT
cord-015021-pol2qm74	8246	2	is	be	VBZ
cord-015021-pol2qm74	8246	3	accempauied	accempauie	VBN
cord-015021-pol2qm74	8246	4	by	by	IN
cord-015021-pol2qm74	8246	5	an	an	DT
cord-015021-pol2qm74	8246	6	influx	influx	NN
cord-015021-pol2qm74	8246	7	of	of	IN
cord-015021-pol2qm74	8246	8	both	both	DT
cord-015021-pol2qm74	8246	9	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8246	10	and	and	CC
cord-015021-pol2qm74	8246	11	macrophages	macrophage	NNS
cord-015021-pol2qm74	8246	12	into	into	IN
cord-015021-pol2qm74	8246	13	the	the	DT
cord-015021-pol2qm74	8246	14	peritoneum	peritoneum	NN
cord-015021-pol2qm74	8246	15	and	and	CC
cord-015021-pol2qm74	8246	16	subsequent	subsequent	JJ
cord-015021-pol2qm74	8246	17	abscess	abscess	NN
cord-015021-pol2qm74	8246	18	formation	formation	NN
cord-015021-pol2qm74	8246	19	.	.	.
cord-015021-pol2qm74	8247	1	Interestingly	interestingly	RB
cord-015021-pol2qm74	8247	2	,	,	,
cord-015021-pol2qm74	8247	3	there	there	EX
cord-015021-pol2qm74	8247	4	is	be	VBZ
cord-015021-pol2qm74	8247	5	little	little	JJ
cord-015021-pol2qm74	8247	6	serum	serum	NN
cord-015021-pol2qm74	8247	7	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8247	8	or	or	CC
cord-015021-pol2qm74	8247	9	TNF	TNF	NNP
cord-015021-pol2qm74	8247	10	seen	see	VBN
cord-015021-pol2qm74	8247	11	in	in	IN
cord-015021-pol2qm74	8247	12	this	this	DT
cord-015021-pol2qm74	8247	13	model	model	NN
cord-015021-pol2qm74	8247	14	despite	despite	IN
cord-015021-pol2qm74	8247	15	TNF	TNF	NNP
cord-015021-pol2qm74	8247	16	mRNA	mRNA	NNP
cord-015021-pol2qm74	8247	17	expression	expression	NN
cord-015021-pol2qm74	8247	18	in	in	IN
cord-015021-pol2qm74	8247	19	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8247	20	macrophages	macrophage	NNS
cord-015021-pol2qm74	8247	21	.	.	.
cord-015021-pol2qm74	8248	1	We	-PRON-	PRP
cord-015021-pol2qm74	8248	2	believe	believe	VBP
cord-015021-pol2qm74	8248	3	this	this	DT
cord-015021-pol2qm74	8248	4	model	model	NN
cord-015021-pol2qm74	8248	5	is	be	VBZ
cord-015021-pol2qm74	8248	6	more	more	RBR
cord-015021-pol2qm74	8248	7	clinically	clinically	RB
cord-015021-pol2qm74	8248	8	relevant	relevant	JJ
cord-015021-pol2qm74	8248	9	than	than	IN
cord-015021-pol2qm74	8248	10	other	other	JJ
cord-015021-pol2qm74	8248	11	models	model	NNS
cord-015021-pol2qm74	8248	12	of	of	IN
cord-015021-pol2qm74	8248	13	endotoxemia	endotoxemia	NN
cord-015021-pol2qm74	8248	14	or	or	CC
cord-015021-pol2qm74	8248	15	bacteremia	bacteremia	NN
cord-015021-pol2qm74	8248	16	in	in	IN
cord-015021-pol2qm74	8248	17	which	which	WDT
cord-015021-pol2qm74	8248	18	different	different	JJ
cord-015021-pol2qm74	8248	19	patterns	pattern	NNS
cord-015021-pol2qm74	8248	20	of	of	IN
cord-015021-pol2qm74	8248	21	cytokine	cytokine	JJ
cord-015021-pol2qm74	8248	22	expression	expression	NN
cord-015021-pol2qm74	8248	23	are	be	VBP
cord-015021-pol2qm74	8248	24	seen	see	VBN
cord-015021-pol2qm74	8248	25	.	.	.
cord-015021-pol2qm74	8249	1	Newer	new	JJR
cord-015021-pol2qm74	8249	2	agents	agent	NNS
cord-015021-pol2qm74	8249	3	aimed	aim	VBN
cord-015021-pol2qm74	8249	4	at	at	IN
cord-015021-pol2qm74	8249	5	reduction	reduction	NN
cord-015021-pol2qm74	8249	6	of	of	IN
cord-015021-pol2qm74	8249	7	systemic	systemic	JJ
cord-015021-pol2qm74	8249	8	manifestations	manifestation	NNS
cord-015021-pol2qm74	8249	9	of	of	IN
cord-015021-pol2qm74	8249	10	sepsis	sepsis	NN
cord-015021-pol2qm74	8249	11	originating	originate	VBG
cord-015021-pol2qm74	8249	12	from	from	IN
cord-015021-pol2qm74	8249	13	intra	intra	JJ
cord-015021-pol2qm74	8249	14	-	-	JJ
cord-015021-pol2qm74	8249	15	abdominal	abdominal	JJ
cord-015021-pol2qm74	8249	16	infection	infection	NN
cord-015021-pol2qm74	8249	17	such	such	JJ
cord-015021-pol2qm74	8249	18	as	as	IN
cord-015021-pol2qm74	8249	19	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8249	20	antibodies	antibody	NNS
cord-015021-pol2qm74	8249	21	against	against	IN
cord-015021-pol2qm74	8249	22	cytokines	cytokine	NNS
cord-015021-pol2qm74	8249	23	or	or	CC
cord-015021-pol2qm74	8249	24	IL-1	IL-1	NNP
cord-015021-pol2qm74	8249	25	receptor	receptor	NN
cord-015021-pol2qm74	8249	26	antagonists	antagonist	NNS
cord-015021-pol2qm74	8249	27	may	may	MD
cord-015021-pol2qm74	8249	28	need	need	VB
cord-015021-pol2qm74	8249	29	to	to	TO
cord-015021-pol2qm74	8249	30	be	be	VB
cord-015021-pol2qm74	8249	31	directed	direct	VBN
cord-015021-pol2qm74	8249	32	against	against	IN
cord-015021-pol2qm74	8249	33	remote	remote	JJ
cord-015021-pol2qm74	8249	34	organ	organ	NN
cord-015021-pol2qm74	8249	35	macrophage	macrophage	NN
cord-015021-pol2qm74	8249	36	populations	population	NNS
cord-015021-pol2qm74	8249	37	while	while	IN
cord-015021-pol2qm74	8249	38	preserving	preserve	VBG
cord-015021-pol2qm74	8249	39	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8249	40	macrophage	macrophage	NN
cord-015021-pol2qm74	8249	41	function	function	NN
cord-015021-pol2qm74	8249	42	.	.	.
cord-015021-pol2qm74	8250	1	Inflammation	inflammation	NN
cord-015021-pol2qm74	8250	2	is	be	VBZ
cord-015021-pol2qm74	8250	3	a	a	DT
cord-015021-pol2qm74	8250	4	complex	complex	JJ
cord-015021-pol2qm74	8250	5	process	process	NN
cord-015021-pol2qm74	8250	6	involving	involve	VBG
cord-015021-pol2qm74	8250	7	microcirculatory	microcirculatory	JJ
cord-015021-pol2qm74	8250	8	changes	change	NNS
cord-015021-pol2qm74	8250	9	,	,	,
cord-015021-pol2qm74	8250	10	extravasation	extravasation	NN
cord-015021-pol2qm74	8250	11	of	of	IN
cord-015021-pol2qm74	8250	12	fluid	fluid	NN
cord-015021-pol2qm74	8250	13	and	and	CC
cord-015021-pol2qm74	8250	14	a	a	DT
cord-015021-pol2qm74	8250	15	cellular	cellular	JJ
cord-015021-pol2qm74	8250	16	influx	influx	NN
cord-015021-pol2qm74	8250	17	in	in	IN
cord-015021-pol2qm74	8250	18	the	the	DT
cord-015021-pol2qm74	8250	19	affected	affect	VBN
cord-015021-pol2qm74	8250	20	body	body	NN
cord-015021-pol2qm74	8250	21	area	area	NN
cord-015021-pol2qm74	8250	22	.	.	.
cord-015021-pol2qm74	8251	1	In	in	IN
cord-015021-pol2qm74	8251	2	our	-PRON-	PRP$
cord-015021-pol2qm74	8251	3	communication	communication	NN
cord-015021-pol2qm74	8251	4	,	,	,
cord-015021-pol2qm74	8251	5	we	-PRON-	PRP
cord-015021-pol2qm74	8251	6	will	will	MD
cord-015021-pol2qm74	8251	7	only	only	RB
cord-015021-pol2qm74	8251	8	consider	consider	VB
cord-015021-pol2qm74	8251	9	the	the	DT
cord-015021-pol2qm74	8251	10	regulation	regulation	NN
cord-015021-pol2qm74	8251	11	of	of	IN
cord-015021-pol2qm74	8251	12	the	the	DT
cord-015021-pol2qm74	8251	13	cellular	cellular	JJ
cord-015021-pol2qm74	8251	14	infiltrate	infiltrate	NN
cord-015021-pol2qm74	8251	15	which	which	WDT
cord-015021-pol2qm74	8251	16	plays	play	VBZ
cord-015021-pol2qm74	8251	17	a	a	DT
cord-015021-pol2qm74	8251	18	major	major	JJ
cord-015021-pol2qm74	8251	19	role	role	NN
cord-015021-pol2qm74	8251	20	in	in	IN
cord-015021-pol2qm74	8251	21	the	the	DT
cord-015021-pol2qm74	8251	22	defense	defense	NN
cord-015021-pol2qm74	8251	23	of	of	IN
cord-015021-pol2qm74	8251	24	the	the	DT
cord-015021-pol2qm74	8251	25	peritoneum	peritoneum	NN
cord-015021-pol2qm74	8251	26	against	against	IN
cord-015021-pol2qm74	8251	27	microbial	microbial	JJ
cord-015021-pol2qm74	8251	28	invasion	invasion	NN
cord-015021-pol2qm74	8251	29	.	.	.
cord-015021-pol2qm74	8252	1	Until	until	IN
cord-015021-pol2qm74	8252	2	recently	recently	RB
cord-015021-pol2qm74	8252	3	,	,	,
cord-015021-pol2qm74	8252	4	it	-PRON-	PRP
cord-015021-pol2qm74	8252	5	was	be	VBD
cord-015021-pol2qm74	8252	6	thought	think	VBN
cord-015021-pol2qm74	8252	7	that	that	IN
cord-015021-pol2qm74	8252	8	the	the	DT
cord-015021-pol2qm74	8252	9	influx	influx	NN
cord-015021-pol2qm74	8252	10	of	of	IN
cord-015021-pol2qm74	8252	11	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	8252	12	in	in	IN
cord-015021-pol2qm74	8252	13	the	the	DT
cord-015021-pol2qm74	8252	14	abdomen	abdomen	NN
cord-015021-pol2qm74	8252	15	was	be	VBD
cord-015021-pol2qm74	8252	16	induced	induce	VBN
cord-015021-pol2qm74	8252	17	by	by	IN
cord-015021-pol2qm74	8252	18	bacterial	bacterial	JJ
cord-015021-pol2qm74	8252	19	products	product	NNS
cord-015021-pol2qm74	8252	20	,	,	,
cord-015021-pol2qm74	8252	21	local	local	JJ
cord-015021-pol2qm74	8252	22	humeral	humeral	JJ
cord-015021-pol2qm74	8252	23	factors	factor	NNS
cord-015021-pol2qm74	8252	24	and	and	CC
cord-015021-pol2qm74	8252	25	secretions	secretion	NNS
cord-015021-pol2qm74	8252	26	of	of	IN
cord-015021-pol2qm74	8252	27	resident	resident	JJ
cord-015021-pol2qm74	8252	28	macrophages	macrophage	NNS
cord-015021-pol2qm74	8252	29	.	.	.
cord-015021-pol2qm74	8253	1	There	there	EX
cord-015021-pol2qm74	8253	2	is	be	VBZ
cord-015021-pol2qm74	8253	3	now	now	RB
cord-015021-pol2qm74	8253	4	increasing	increase	VBG
cord-015021-pol2qm74	8253	5	evidence	evidence	NN
cord-015021-pol2qm74	8253	6	that	that	IN
cord-015021-pol2qm74	8253	7	this	this	DT
cord-015021-pol2qm74	8253	8	view	view	NN
cord-015021-pol2qm74	8253	9	is	be	VBZ
cord-015021-pol2qm74	8253	10	too	too	RB
cord-015021-pol2qm74	8253	11	simplistic	simplistic	JJ
cord-015021-pol2qm74	8253	12	.	.	.
cord-015021-pol2qm74	8254	1	Many	many	JJ
cord-015021-pol2qm74	8254	2	other	other	JJ
cord-015021-pol2qm74	8254	3	cell	cell	NN
cord-015021-pol2qm74	8254	4	types	type	NNS
cord-015021-pol2qm74	8254	5	present	present	JJ
cord-015021-pol2qm74	8254	6	in	in	IN
cord-015021-pol2qm74	8254	7	the	the	DT
cord-015021-pol2qm74	8254	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	8254	9	cavity	cavity	NN
cord-015021-pol2qm74	8254	10	or	or	CC
cord-015021-pol2qm74	8254	11	composing	compose	VBG
cord-015021-pol2qm74	8254	12	the	the	DT
cord-015021-pol2qm74	8254	13	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8254	14	membrane	membrane	NN
cord-015021-pol2qm74	8254	15	(	(	-LRB-
cord-015021-pol2qm74	8254	16	mast	mast	NN
cord-015021-pol2qm74	8254	17	-	-	HYPH
cord-015021-pol2qm74	8254	18	cells	cell	NNS
cord-015021-pol2qm74	8254	19	,	,	,
cord-015021-pol2qm74	8254	20	mesothelial	mesothelial	JJ
cord-015021-pol2qm74	8254	21	cells	cell	NNS
cord-015021-pol2qm74	8254	22	,	,	,
cord-015021-pol2qm74	8254	23	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	8254	24	)	)	-RRB-
cord-015021-pol2qm74	8254	25	are	be	VBP
cord-015021-pol2qm74	8254	26	able	able	JJ
cord-015021-pol2qm74	8254	27	to	to	TO
cord-015021-pol2qm74	8254	28	release	release	VB
cord-015021-pol2qm74	8254	29	or	or	CC
cord-015021-pol2qm74	8254	30	secrete	secrete	VB
cord-015021-pol2qm74	8254	31	vasoactive	vasoactive	JJ
cord-015021-pol2qm74	8254	32	or	or	CC
cord-015021-pol2qm74	8254	33	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	8254	34	substances	substance	NNS
cord-015021-pol2qm74	8254	35	such	such	JJ
cord-015021-pol2qm74	8254	36	as	as	IN
cord-015021-pol2qm74	8254	37	histamine	histamine	NN
cord-015021-pol2qm74	8254	38	,	,	,
cord-015021-pol2qm74	8254	39	prostagtandines	prostagtandine	NNS
cord-015021-pol2qm74	8254	40	,	,	,
cord-015021-pol2qm74	8254	41	or	or	CC
cord-015021-pol2qm74	8254	42	cytokines	cytokine	NNS
cord-015021-pol2qm74	8254	43	.	.	.
cord-015021-pol2qm74	8255	1	They	-PRON-	PRP
cord-015021-pol2qm74	8255	2	are	be	VBP
cord-015021-pol2qm74	8255	3	most	most	RBS
cord-015021-pol2qm74	8255	4	likely	likely	JJ
cord-015021-pol2qm74	8255	5	to	to	TO
cord-015021-pol2qm74	8255	6	play	play	VB
cord-015021-pol2qm74	8255	7	a	a	DT
cord-015021-pol2qm74	8255	8	role	role	NN
cord-015021-pol2qm74	8255	9	in	in	IN
cord-015021-pol2qm74	8255	10	the	the	DT
cord-015021-pol2qm74	8255	11	regulation	regulation	NN
cord-015021-pol2qm74	8255	12	of	of	IN
cord-015021-pol2qm74	8255	13	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	8255	14	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8255	15	reactions	reaction	NNS
cord-015021-pol2qm74	8255	16	.	.	.
cord-015021-pol2qm74	8256	1	The	the	DT
cord-015021-pol2qm74	8256	2	emigration	emigration	NN
cord-015021-pol2qm74	8256	3	of	of	IN
cord-015021-pol2qm74	8256	4	leukocytes	leukocyte	NNS
cord-015021-pol2qm74	8256	5	towards	towards	IN
cord-015021-pol2qm74	8256	6	the	the	DT
cord-015021-pol2qm74	8256	7	abdominal	abdominal	JJ
cord-015021-pol2qm74	8256	8	cavity	cavity	NN
cord-015021-pol2qm74	8256	9	is	be	VBZ
cord-015021-pol2qm74	8256	10	also	also	RB
cord-015021-pol2qm74	8256	11	modulated	modulate	VBN
cord-015021-pol2qm74	8256	12	by	by	IN
cord-015021-pol2qm74	8256	13	a	a	DT
cord-015021-pol2qm74	8256	14	previous	previous	JJ
cord-015021-pol2qm74	8256	15	contact	contact	NN
cord-015021-pol2qm74	8256	16	with	with	IN
cord-015021-pol2qm74	8256	17	Gram	Gram	NNP
cord-015021-pol2qm74	8256	18	negative	negative	JJ
cord-015021-pol2qm74	8256	19	bacteria	bacteria	NNS
cord-015021-pol2qm74	8256	20	.	.	.
cord-015021-pol2qm74	8257	1	In	in	IN
cord-015021-pol2qm74	8257	2	the	the	DT
cord-015021-pol2qm74	8257	3	rat	rat	NN
cord-015021-pol2qm74	8257	4	,	,	,
cord-015021-pol2qm74	8257	5	this	this	DT
cord-015021-pol2qm74	8257	6	intriguing	intriguing	JJ
cord-015021-pol2qm74	8257	7	phenomenon	phenomenon	NN
cord-015021-pol2qm74	8257	8	is	be	VBZ
cord-015021-pol2qm74	8257	9	long	long	RB
cord-015021-pol2qm74	8257	10	lasting	last	VBG
cord-015021-pol2qm74	8257	11	,	,	,
cord-015021-pol2qm74	8257	12	can	can	MD
cord-015021-pol2qm74	8257	13	not	not	RB
cord-015021-pol2qm74	8257	14	be	be	VB
cord-015021-pol2qm74	8257	15	transferred	transfer	VBN
cord-015021-pol2qm74	8257	16	by	by	IN
cord-015021-pol2qm74	8257	17	serum	serum	NN
cord-015021-pol2qm74	8257	18	and	and	CC
cord-015021-pol2qm74	8257	19	seems	seem	VBZ
cord-015021-pol2qm74	8257	20	independent	independent	JJ
cord-015021-pol2qm74	8257	21	from	from	IN
cord-015021-pol2qm74	8257	22	T	T	NNP
cord-015021-pol2qm74	8257	23	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8257	24	.	.	.
cord-015021-pol2qm74	8258	1	The	the	DT
cord-015021-pol2qm74	8258	2	clinical	clinical	JJ
cord-015021-pol2qm74	8258	3	relevance	relevance	NN
cord-015021-pol2qm74	8258	4	of	of	IN
cord-015021-pol2qm74	8258	5	these	these	DT
cord-015021-pol2qm74	8258	6	various	various	JJ
cord-015021-pol2qm74	8258	7	regulating	regulating	NN
cord-015021-pol2qm74	8258	8	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8258	9	has	have	VBZ
cord-015021-pol2qm74	8258	10	still	still	RB
cord-015021-pol2qm74	8258	11	to	to	TO
cord-015021-pol2qm74	8258	12	be	be	VB
cord-015021-pol2qm74	8258	13	determined	determine	VBN
cord-015021-pol2qm74	8258	14	.	.	.
cord-015021-pol2qm74	8259	1	Kinnaert	Kinnaert	NNP
cord-015021-pol2qm74	8259	2	Paul	Paul	NNP
cord-015021-pol2qm74	8259	3	,	,	,
cord-015021-pol2qm74	8259	4	H6pital	H6pital	NNP
cord-015021-pol2qm74	8259	5	Erasme	Erasme	NNP
cord-015021-pol2qm74	8259	6	,	,	,
cord-015021-pol2qm74	8259	7	Route	Route	NNP
cord-015021-pol2qm74	8259	8	de	de	NNP
cord-015021-pol2qm74	8259	9	Lennik	Lennik	NNP
cord-015021-pol2qm74	8259	10	808	808	CD
cord-015021-pol2qm74	8260	1	,	,	,
cord-015021-pol2qm74	8260	2	1070	1070	CD
cord-015021-pol2qm74	8260	3	Bruxelles	Bruxelles	NNP
cord-015021-pol2qm74	8260	4	Belgium	Belgium	NNP
cord-015021-pol2qm74	8260	5	Generalized	generalized	JJ
cord-015021-pol2qm74	8260	6	response	response	NN
cord-015021-pol2qm74	8260	7	in	in	IN
cord-015021-pol2qm74	8260	8	secondary	secondary	JJ
cord-015021-pol2qm74	8260	9	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8261	1	The	the	DT
cord-015021-pol2qm74	8261	2	clinical	clinical	JJ
cord-015021-pol2qm74	8261	3	course	course	NN
cord-015021-pol2qm74	8261	4	of	of	IN
cord-015021-pol2qm74	8261	5	an	an	DT
cord-015021-pol2qm74	8261	6	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8261	7	infection	infection	NN
cord-015021-pol2qm74	8261	8	may	may	MD
cord-015021-pol2qm74	8261	9	depend	depend	VB
cord-015021-pol2qm74	8261	10	on	on	IN
cord-015021-pol2qm74	8261	11	a	a	DT
cord-015021-pol2qm74	8261	12	variety	variety	NN
cord-015021-pol2qm74	8261	13	of	of	IN
cord-015021-pol2qm74	8261	14	variables	variable	NNS
cord-015021-pol2qm74	8261	15	including	include	VBG
cord-015021-pol2qm74	8261	16	the	the	DT
cord-015021-pol2qm74	8261	17	capacity	capacity	NN
cord-015021-pol2qm74	8261	18	of	of	IN
cord-015021-pol2qm74	8261	19	host	host	NN
cord-015021-pol2qm74	8261	20	defense	defense	NN
cord-015021-pol2qm74	8261	21	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8261	22	and	and	CC
cord-015021-pol2qm74	8261	23	the	the	DT
cord-015021-pol2qm74	8261	24	degree	degree	NN
cord-015021-pol2qm74	8261	25	of	of	IN
cord-015021-pol2qm74	8261	26	the	the	DT
cord-015021-pol2qm74	8261	27	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8261	28	response	response	NN
cord-015021-pol2qm74	8261	29	.	.	.
cord-015021-pol2qm74	8262	1	If	if	IN
cord-015021-pol2qm74	8262	2	local	local	JJ
cord-015021-pol2qm74	8262	3	defense	defense	NN
cord-015021-pol2qm74	8262	4	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8262	5	fail	fail	VBP
cord-015021-pol2qm74	8262	6	to	to	TO
cord-015021-pol2qm74	8262	7	restrict	restrict	VB
cord-015021-pol2qm74	8262	8	the	the	DT
cord-015021-pol2qm74	8262	9	inflammation	inflammation	NN
cord-015021-pol2qm74	8262	10	to	to	IN
cord-015021-pol2qm74	8262	11	the	the	DT
cord-015021-pol2qm74	8262	12	abdominal	abdominal	JJ
cord-015021-pol2qm74	8262	13	cavity	cavity	NN
cord-015021-pol2qm74	8262	14	a	a	DT
cord-015021-pol2qm74	8262	15	generalized	generalized	JJ
cord-015021-pol2qm74	8262	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8262	17	reponse	reponse	NN
cord-015021-pol2qm74	8262	18	will	will	MD
cord-015021-pol2qm74	8262	19	result	result	VB
cord-015021-pol2qm74	8262	20	.	.	.
cord-015021-pol2qm74	8263	1	in	in	IN
cord-015021-pol2qm74	8263	2	a	a	DT
cord-015021-pol2qm74	8263	3	first	first	JJ
cord-015021-pol2qm74	8263	4	stage	stage	NN
cord-015021-pol2qm74	8263	5	generalized	generalize	VBN
cord-015021-pol2qm74	8263	6	signs	sign	NNS
cord-015021-pol2qm74	8263	7	of	of	IN
cord-015021-pol2qm74	8263	8	a	a	DT
cord-015021-pol2qm74	8263	9	local	local	JJ
cord-015021-pol2qm74	8263	10	inflammation	inflammation	NN
cord-015021-pol2qm74	8263	11	become	become	VBP
cord-015021-pol2qm74	8263	12	detectable	detectable	JJ
cord-015021-pol2qm74	8263	13	whereas	whereas	IN
cord-015021-pol2qm74	8263	14	the	the	DT
cord-015021-pol2qm74	8263	15	second	second	JJ
cord-015021-pol2qm74	8263	16	stage	stage	NN
cord-015021-pol2qm74	8263	17	comprises	comprise	VBZ
cord-015021-pol2qm74	8263	18	the	the	DT
cord-015021-pol2qm74	8263	19	overwhelming	overwhelming	JJ
cord-015021-pol2qm74	8263	20	systemic	systemic	JJ
cord-015021-pol2qm74	8263	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8263	22	response	response	NN
cord-015021-pol2qm74	8263	23	.	.	.
cord-015021-pol2qm74	8264	1	The	the	DT
cord-015021-pol2qm74	8264	2	extent	extent	NN
cord-015021-pol2qm74	8264	3	of	of	IN
cord-015021-pol2qm74	8264	4	this	this	DT
cord-015021-pol2qm74	8264	5	systemic	systemic	JJ
cord-015021-pol2qm74	8264	6	response	response	NN
cord-015021-pol2qm74	8264	7	determines	determine	VBZ
cord-015021-pol2qm74	8264	8	the	the	DT
cord-015021-pol2qm74	8264	9	outcome	outcome	NN
cord-015021-pol2qm74	8264	10	.	.	.
cord-015021-pol2qm74	8265	1	Sometimes	sometimes	RB
cord-015021-pol2qm74	8265	2	it	-PRON-	PRP
cord-015021-pol2qm74	8265	3	may	may	MD
cord-015021-pol2qm74	8265	4	appear	appear	VB
cord-015021-pol2qm74	8265	5	to	to	TO
cord-015021-pol2qm74	8265	6	be	be	VB
cord-015021-pol2qm74	8265	7	unrelated	unrelated	JJ
cord-015021-pol2qm74	8265	8	to	to	IN
cord-015021-pol2qm74	8265	9	the	the	DT
cord-015021-pol2qm74	8265	10	severity	severity	NN
cord-015021-pol2qm74	8265	11	of	of	IN
cord-015021-pol2qm74	8265	12	the	the	DT
cord-015021-pol2qm74	8265	13	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	8265	14	findings	finding	NNS
cord-015021-pol2qm74	8265	15	.	.	.
cord-015021-pol2qm74	8266	1	The	the	DT
cord-015021-pol2qm74	8266	2	activation	activation	NN
cord-015021-pol2qm74	8266	3	of	of	IN
cord-015021-pol2qm74	8266	4	plasma	plasma	NN
cord-015021-pol2qm74	8266	5	systems	system	NNS
cord-015021-pol2qm74	8266	6	and	and	CC
cord-015021-pol2qm74	8266	7	cellular	cellular	JJ
cord-015021-pol2qm74	8266	8	elements	element	NNS
cord-015021-pol2qm74	8266	9	leads	lead	VBZ
cord-015021-pol2qm74	8266	10	to	to	IN
cord-015021-pol2qm74	8266	11	a	a	DT
cord-015021-pol2qm74	8266	12	fast	fast	JJ
cord-015021-pol2qm74	8266	13	release	release	NN
cord-015021-pol2qm74	8266	14	of	of	IN
cord-015021-pol2qm74	8266	15	cytokines	cytokine	NNS
cord-015021-pol2qm74	8266	16	,	,	,
cord-015021-pol2qm74	8266	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8266	18	mediators	mediator	NNS
cord-015021-pol2qm74	8266	19	and	and	CC
cord-015021-pol2qm74	8266	20	other	other	JJ
cord-015021-pol2qm74	8266	21	substances	substance	NNS
cord-015021-pol2qm74	8266	22	.	.	.
cord-015021-pol2qm74	8267	1	These	these	DT
cord-015021-pol2qm74	8267	2	parameters	parameter	NNS
cord-015021-pol2qm74	8267	3	precisely	precisely	RB
cord-015021-pol2qm74	8267	4	reflect	reflect	VBP
cord-015021-pol2qm74	8267	5	the	the	DT
cord-015021-pol2qm74	8267	6	degree	degree	NN
cord-015021-pol2qm74	8267	7	of	of	IN
cord-015021-pol2qm74	8267	8	the	the	DT
cord-015021-pol2qm74	8267	9	generalized	generalized	JJ
cord-015021-pol2qm74	8267	10	response	response	NN
cord-015021-pol2qm74	8267	11	.	.	.
cord-015021-pol2qm74	8268	1	Inflammation	inflammation	NN
cord-015021-pol2qm74	8268	2	of	of	IN
cord-015021-pol2qm74	8268	3	the	the	DT
cord-015021-pol2qm74	8268	4	peritoneum	peritoneum	NN
cord-015021-pol2qm74	8268	5	causes	cause	VBZ
cord-015021-pol2qm74	8268	6	significant	significant	JJ
cord-015021-pol2qm74	8268	7	morbidity	morbidity	NN
cord-015021-pol2qm74	8268	8	.	.	.
cord-015021-pol2qm74	8269	1	OBJEKTIVES	OBJEKTIVES	NNP
cord-015021-pol2qm74	8269	2	:	:	:
cord-015021-pol2qm74	8270	1	To	to	TO
cord-015021-pol2qm74	8270	2	test	test	VB
cord-015021-pol2qm74	8270	3	the	the	DT
cord-015021-pol2qm74	8270	4	hypothesis	hypothesis	NN
cord-015021-pol2qm74	8270	5	that	that	IN
cord-015021-pol2qm74	8270	6	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8270	7	mesothelial	mesothelial	JJ
cord-015021-pol2qm74	8270	8	cells	cell	NNS
cord-015021-pol2qm74	8270	9	play	play	VBP
cord-015021-pol2qm74	8270	10	a	a	DT
cord-015021-pol2qm74	8270	11	role	role	NN
cord-015021-pol2qm74	8270	12	in	in	IN
cord-015021-pol2qm74	8270	13	regulating	regulate	VBG
cord-015021-pol2qm74	8270	14	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8270	15	responses	response	NNS
cord-015021-pol2qm74	8270	16	within	within	IN
cord-015021-pol2qm74	8270	17	the	the	DT
cord-015021-pol2qm74	8270	18	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8270	19	cavity	cavity	NN
cord-015021-pol2qm74	8270	20	,	,	,
cord-015021-pol2qm74	8270	21	we	-PRON-	PRP
cord-015021-pol2qm74	8270	22	examined	examine	VBD
cord-015021-pol2qm74	8270	23	neutrophil	neutrophil	NN
cord-015021-pol2qm74	8270	24	-	-	HYPH
cord-015021-pol2qm74	8270	25	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	8270	26	activity	activity	NN
cord-015021-pol2qm74	8270	27	(	(	-LRB-
cord-015021-pol2qm74	8270	28	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	8270	29	8)	8)	NN
cord-015021-pol2qm74	8270	30	and	and	CC
cord-015021-pol2qm74	8270	31	monocyte	monocyte	NNP
cord-015021-pol2qm74	8270	32	-	-	HYPH
cord-015021-pol2qm74	8270	33	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	8270	34	cytokine	cytokine	NN
cord-015021-pol2qm74	8270	35	(	(	-LRB-
cord-015021-pol2qm74	8270	36	MCP	MCP	NNP
cord-015021-pol2qm74	8270	37	)	)	-RRB-
cord-015021-pol2qm74	8270	38	release	release	NN
cord-015021-pol2qm74	8270	39	by	by	IN
cord-015021-pol2qm74	8270	40	sytokine	sytokine	NN
cord-015021-pol2qm74	8270	41	-	-	HYPH
cord-015021-pol2qm74	8270	42	etimulated	etimulate	VBN
cord-015021-pol2qm74	8270	43	mesothelial	mesothelial	JJ
cord-015021-pol2qm74	8270	44	cells	cell	NNS
cord-015021-pol2qm74	8270	45	.	.	.
cord-015021-pol2qm74	8271	1	Confluent	Confluent	NNP
cord-015021-pol2qm74	8271	2	human	human	JJ
cord-015021-pol2qm74	8271	3	peritoneal	peritoneal	NN
cord-015021-pol2qm74	8271	4	mesothelial	mesothelial	JJ
cord-015021-pol2qm74	8271	5	cells	cell	NNS
cord-015021-pol2qm74	8271	6	were	be	VBD
cord-015021-pol2qm74	8271	7	exposed	expose	VBN
cord-015021-pol2qm74	8271	8	to	to	IN
cord-015021-pol2qm74	8271	9	varying	vary	VBG
cord-015021-pol2qm74	8271	10	concentrations	concentration	NNS
cord-015021-pol2qm74	8271	11	of	of	IN
cord-015021-pol2qm74	8271	12	phorbolmyristate	phorbolmyristate	JJ
cord-015021-pol2qm74	8271	13	-	-	HYPH
cord-015021-pol2qm74	8271	14	acetate	acetate	JJ
cord-015021-pol2qm74	8271	15	(	(	-LRB-
cord-015021-pol2qm74	8271	16	PMA	PMA	NNP
cord-015021-pol2qm74	8271	17	)	)	-RRB-
cord-015021-pol2qm74	8271	18	and	and	CC
cord-015021-pol2qm74	8271	19	the	the	DT
cord-015021-pol2qm74	8271	20	cytokines	cytokine	NNS
cord-015021-pol2qm74	8271	21	tumorneerosis	tumorneerosis	NN
cord-015021-pol2qm74	8271	22	factor	factor	NN
cord-015021-pol2qm74	8271	23	a	a	DT
cord-015021-pol2qm74	8271	24	(	(	-LRB-
cord-015021-pol2qm74	8271	25	TNF	TNF	NNP
cord-015021-pol2qm74	8271	26	a	a	DT
cord-015021-pol2qm74	8271	27	)	)	-RRB-
cord-015021-pol2qm74	8272	1	and	and	CC
cord-015021-pol2qm74	8272	2	Interleukin	Interleukin	NNP
cord-015021-pol2qm74	8272	3	i~	i~	XX
cord-015021-pol2qm74	8273	1	(	(	-LRB-
cord-015021-pol2qm74	8273	2	IL	IL	NNP
cord-015021-pol2qm74	8273	3	-	-	HYPH
cord-015021-pol2qm74	8273	4	I~	I~	NNP
cord-015021-pol2qm74	8273	5	)	)	-RRB-
cord-015021-pol2qm74	8273	6	.	.	.
cord-015021-pol2qm74	8274	1	The	the	DT
cord-015021-pol2qm74	8274	2	supernatant	supernatant	NN
cord-015021-pol2qm74	8274	3	was	be	VBD
cord-015021-pol2qm74	8274	4	examined	examine	VBN
cord-015021-pol2qm74	8274	5	for	for	IN
cord-015021-pol2qm74	8274	6	IL-8	IL-8	NNP
cord-015021-pol2qm74	8274	7	by	by	IN
cord-015021-pol2qm74	8274	8	ELISA	ELISA	NNP
cord-015021-pol2qm74	8274	9	and	and	CC
cord-015021-pol2qm74	8274	10	for	for	IN
cord-015021-pol2qm74	8274	11	MCP	MCP	NNP
cord-015021-pol2qm74	8274	12	by	by	IN
cord-015021-pol2qm74	8274	13	investigating	investigate	VBG
cord-015021-pol2qm74	8274	14	the	the	DT
cord-015021-pol2qm74	8274	15	ehemotactic	ehemotactic	JJ
cord-015021-pol2qm74	8274	16	activity	activity	NN
cord-015021-pol2qm74	8274	17	for	for	IN
cord-015021-pol2qm74	8274	18	isolated	isolate	VBN
cord-015021-pol2qm74	8274	19	human	human	JJ
cord-015021-pol2qm74	8274	20	monocytes	monocyte	NNS
cord-015021-pol2qm74	8274	21	.	.	.
cord-015021-pol2qm74	8275	1	Mesothelial	mesothelial	JJ
cord-015021-pol2qm74	8275	2	cells	cell	NNS
cord-015021-pol2qm74	8275	3	express	express	VBP
cord-015021-pol2qm74	8275	4	low	low	JJ
cord-015021-pol2qm74	8275	5	levels	level	NNS
cord-015021-pol2qm74	8275	6	of	of	IN
cord-015021-pol2qm74	8275	7	IL	IL	NNP
cord-015021-pol2qm74	8275	8	8	8	CD
cord-015021-pol2qm74	8275	9	and	and	CC
cord-015021-pol2qm74	8275	10	monocyte	monocyte	NNP
cord-015021-pol2qm74	8275	11	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	8275	12	activity	activity	NN
cord-015021-pol2qm74	8275	13	when	when	WRB
cord-015021-pol2qm74	8275	14	cultured	culture	VBN
cord-015021-pol2qm74	8275	15	.	.	.
cord-015021-pol2qm74	8276	1	These	these	DT
cord-015021-pol2qm74	8276	2	activies	activie	NNS
cord-015021-pol2qm74	8276	3	were	be	VBD
cord-015021-pol2qm74	8276	4	significantly	significantly	RB
cord-015021-pol2qm74	8276	5	increased	increase	VBN
cord-015021-pol2qm74	8276	6	(	(	-LRB-
cord-015021-pol2qm74	8276	7	2-fold	2-fold	CD
cord-015021-pol2qm74	8276	8	)	)	-RRB-
cord-015021-pol2qm74	8276	9	after	after	IN
cord-015021-pol2qm74	8276	10	stimulation	stimulation	NN
cord-015021-pol2qm74	8276	11	with	with	IN
cord-015021-pol2qm74	8276	12	either	either	CC
cord-015021-pol2qm74	8276	13	TNF	TNF	NNP
cord-015021-pol2qm74	8276	14	a	a	NNP
cord-015021-pol2qm74	8276	15	or	or	CC
cord-015021-pol2qm74	8276	16	IL	IL	NNP
cord-015021-pol2qm74	8276	17	-	-	HYPH
cord-015021-pol2qm74	8276	18	I~.	I~.	NNP
cord-015021-pol2qm74	8277	1	Additionally	additionally	RB
cord-015021-pol2qm74	8277	2	macrophage	macrophage	NN
cord-015021-pol2qm74	8277	3	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8277	4	protein	protein	NN
cord-015021-pol2qm74	8277	5	was	be	VBD
cord-015021-pol2qm74	8277	6	detected	detect	VBN
cord-015021-pol2qm74	8277	7	.	.	.
cord-015021-pol2qm74	8278	1	These	these	DT
cord-015021-pol2qm74	8278	2	observations	observation	NNS
cord-015021-pol2qm74	8278	3	provide	provide	VBP
cord-015021-pol2qm74	8278	4	a	a	DT
cord-015021-pol2qm74	8278	5	probably	probably	RB
cord-015021-pol2qm74	8278	6	important	important	JJ
cord-015021-pol2qm74	8278	7	mechanism	mechanism	NN
cord-015021-pol2qm74	8278	8	whereby	whereby	WRB
cord-015021-pol2qm74	8278	9	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8278	10	mesothelial	mesothelial	JJ
cord-015021-pol2qm74	8278	11	cells	cell	NNS
cord-015021-pol2qm74	8278	12	respond	respond	VBP
cord-015021-pol2qm74	8278	13	to	to	IN
cord-015021-pol2qm74	8278	14	imflammatory	imflammatory	NN
cord-015021-pol2qm74	8278	15	stimuli	stimulus	NNS
cord-015021-pol2qm74	8278	16	released	release	VBN
cord-015021-pol2qm74	8278	17	during	during	IN
cord-015021-pol2qm74	8278	18	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8278	19	and	and	CC
cord-015021-pol2qm74	8278	20	how	how	WRB
cord-015021-pol2qm74	8278	21	leucocyte	leucocyte	JJ
cord-015021-pol2qm74	8278	22	recruitment	recruitment	NN
cord-015021-pol2qm74	8278	23	by	by	IN
cord-015021-pol2qm74	8278	24	liberation	liberation	NN
cord-015021-pol2qm74	8278	25	of	of	IN
cord-015021-pol2qm74	8278	26	chemotactic	chemotactic	JJ
cord-015021-pol2qm74	8278	27	cytokines	cytokine	NNS
cord-015021-pol2qm74	8278	28	is	be	VBZ
cord-015021-pol2qm74	8278	29	regulated	regulate	VBN
cord-015021-pol2qm74	8278	30	.	.	.
cord-015021-pol2qm74	8279	1	The	the	DT
cord-015021-pol2qm74	8279	2	perioperative	perioperative	JJ
cord-015021-pol2qm74	8279	3	course	course	NN
cord-015021-pol2qm74	8279	4	of	of	IN
cord-015021-pol2qm74	8279	5	LPS	LPS	NNP
cord-015021-pol2qm74	8279	6	,	,	,
cord-015021-pol2qm74	8279	7	TNFa	TNFa	NNS
cord-015021-pol2qm74	8279	8	and	and	CC
cord-015021-pol2qm74	8280	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	8280	2	in	in	IN
cord-015021-pol2qm74	8280	3	19	19	CD
cord-015021-pol2qm74	8280	4	patients	patient	NNS
cord-015021-pol2qm74	8280	5	with	with	IN
cord-015021-pol2qm74	8280	6	bacteriologic	bacteriologic	NNP
cord-015021-pol2qm74	8280	7	proven	prove	VBN
cord-015021-pol2qm74	8280	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	8280	9	infection	infection	NN
cord-015021-pol2qm74	8280	10	(	(	-LRB-
cord-015021-pol2qm74	8280	11	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8280	12	abscess	abscess	NN
cord-015021-pol2qm74	8280	13	10	10	CD
cord-015021-pol2qm74	8280	14	,	,	,
cord-015021-pol2qm74	8280	15	diffuse	diffuse	VB
cord-015021-pol2qm74	8280	16	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8280	17	4	4	CD
cord-015021-pol2qm74	8280	18	,	,	,
cord-015021-pol2qm74	8280	19	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8280	20	necrosis	necrosis	NN
cord-015021-pol2qm74	8280	21	2	2	CD
cord-015021-pol2qm74	8280	22	,	,	,
cord-015021-pol2qm74	8280	23	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8280	24	abscess	abscess	NN
cord-015021-pol2qm74	8280	25	3	3	CD
cord-015021-pol2qm74	8280	26	)	)	-RRB-
cord-015021-pol2qm74	8280	27	was	be	VBD
cord-015021-pol2qm74	8280	28	followed	follow	VBN
cord-015021-pol2qm74	8280	29	prospectively	prospectively	RB
cord-015021-pol2qm74	8280	30	and	and	CC
cord-015021-pol2qm74	8280	31	evaluated	evaluate	VBN
cord-015021-pol2qm74	8280	32	for	for	IN
cord-015021-pol2qm74	8280	33	possible	possible	JJ
cord-015021-pol2qm74	8280	34	correlation	correlation	NN
cord-015021-pol2qm74	8280	35	with	with	IN
cord-015021-pol2qm74	8280	36	septic	septic	JJ
cord-015021-pol2qm74	8280	37	state	state	NN
cord-015021-pol2qm74	8280	38	and	and	CC
cord-015021-pol2qm74	8280	39	organ	organ	NN
cord-015021-pol2qm74	8280	40	function	function	NN
cord-015021-pol2qm74	8280	41	.	.	.
cord-015021-pol2qm74	8281	1	Methods	method	NNS
cord-015021-pol2qm74	8281	2	:	:	:
cord-015021-pol2qm74	8281	3	Patients	patient	NNS
cord-015021-pol2qm74	8281	4	were	be	VBD
cord-015021-pol2qm74	8281	5	studied	study	VBN
cord-015021-pol2qm74	8281	6	in	in	IN
cord-015021-pol2qm74	8281	7	a	a	DT
cord-015021-pol2qm74	8281	8	6	6	CD
cord-015021-pol2qm74	8281	9	to	to	TO
cord-015021-pol2qm74	8281	10	10	10	CD
cord-015021-pol2qm74	8281	11	hours	hour	NNS
cord-015021-pol2qm74	8281	12	period	period	NN
cord-015021-pol2qm74	8281	13	during	during	IN
cord-015021-pol2qm74	8281	14	their	-PRON-	PRP$
cord-015021-pol2qm74	8281	15	first	first	JJ
cord-015021-pol2qm74	8281	16	surgical	surgical	JJ
cord-015021-pol2qm74	8281	17	intervention	intervention	NN
cord-015021-pol2qm74	8281	18	because	because	IN
cord-015021-pol2qm74	8281	19	of	of	IN
cord-015021-pol2qm74	8281	20	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8281	21	infection	infection	NN
cord-015021-pol2qm74	8281	22	.	.	.
cord-015021-pol2qm74	8282	1	All	all	DT
cord-015021-pol2qm74	8282	2	were	be	VBD
cord-015021-pol2qm74	8282	3	monitored	monitor	VBN
cord-015021-pol2qm74	8282	4	for	for	IN
cord-015021-pol2qm74	8282	5	their	-PRON-	PRP$
cord-015021-pol2qm74	8282	6	cardiovascular	cardiovascular	JJ
cord-015021-pol2qm74	8282	7	,	,	,
cord-015021-pol2qm74	8282	8	respiratory	respiratory	JJ
cord-015021-pol2qm74	8282	9	,	,	,
cord-015021-pol2qm74	8282	10	hepatic	hepatic	JJ
cord-015021-pol2qm74	8282	11	and	and	CC
cord-015021-pol2qm74	8282	12	renal	renal	JJ
cord-015021-pol2qm74	8282	13	function	function	NN
cord-015021-pol2qm74	8282	14	.	.	.
cord-015021-pol2qm74	8283	1	Plasma	plasma	NN
cord-015021-pol2qm74	8283	2	samples	sample	NNS
cord-015021-pol2qm74	8283	3	for	for	IN
cord-015021-pol2qm74	8283	4	LPS	lp	NNS
cord-015021-pol2qm74	8283	5	.	.	.
cord-015021-pol2qm74	8284	1	TNFa	TNFa	NNP
cord-015021-pol2qm74	8284	2	and	and	CC
cord-015021-pol2qm74	8284	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	8284	4	determination	determination	NN
cord-015021-pol2qm74	8284	5	were	be	VBD
cord-015021-pol2qm74	8284	6	drawn	draw	VBN
cord-015021-pol2qm74	8284	7	preoperatively	preoperatively	RB
cord-015021-pol2qm74	8284	8	,	,	,
cord-015021-pol2qm74	8284	9	intraoperatively	intraoperatively	RB
cord-015021-pol2qm74	8284	10	,	,	,
cord-015021-pol2qm74	8284	11	and	and	CC
cord-015021-pol2qm74	8284	12	until	until	IN
cord-015021-pol2qm74	8284	13	2h	2h	CD
cord-015021-pol2qm74	8284	14	postoperatively	postoperatively	RB
cord-015021-pol2qm74	8284	15	in	in	IN
cord-015021-pol2qm74	8284	16	regular	regular	JJ
cord-015021-pol2qm74	8284	17	intervals	interval	NNS
cord-015021-pol2qm74	8284	18	(	(	-LRB-
cord-015021-pol2qm74	8284	19	min	min	NNP
cord-015021-pol2qm74	8284	20	7	7	CD
cord-015021-pol2qm74	8284	21	/	/	SYM
cord-015021-pol2qm74	8284	22	pat	pat	NNP
cord-015021-pol2qm74	8284	23	)	)	-RRB-
cord-015021-pol2qm74	8285	1	,	,	,
cord-015021-pol2qm74	8285	2	Results	result	NNS
cord-015021-pol2qm74	8285	3	:	:	:
cord-015021-pol2qm74	8286	1	Preoperative	Preoperative	NNP
cord-015021-pol2qm74	8286	2	APACHE	APACHE	NNP
cord-015021-pol2qm74	8286	3	II	II	NNP
cord-015021-pol2qm74	8286	4	was	be	VBD
cord-015021-pol2qm74	8286	5	12	12	CD
cord-015021-pol2qm74	8286	6	in	in	IN
cord-015021-pol2qm74	8286	7	median	median	NN
cord-015021-pol2qm74	8286	8	(	(	-LRB-
cord-015021-pol2qm74	8286	9	rain	rain	NN
cord-015021-pol2qm74	8286	10	4	4	CD
cord-015021-pol2qm74	8286	11	,	,	,
cord-015021-pol2qm74	8286	12	max	max	NNP
cord-015021-pol2qm74	8286	13	25	25	CD
cord-015021-pol2qm74	8286	14	)	)	-RRB-
cord-015021-pol2qm74	8286	15	.	.	.
cord-015021-pol2qm74	8287	1	10	10	CD
cord-015021-pol2qm74	8287	2	patients	patient	NNS
cord-015021-pol2qm74	8287	3	fulfilled	fulfil	VBD
cord-015021-pol2qm74	8287	4	the	the	DT
cord-015021-pol2qm74	8287	5	criteria	criterion	NNS
cord-015021-pol2qm74	8287	6	of	of	IN
cord-015021-pol2qm74	8287	7	SIRS	SIRS	NNP
cord-015021-pol2qm74	8287	8	.	.	.
cord-015021-pol2qm74	8288	1	4	4	CD
cord-015021-pol2qm74	8288	2	of	of	IN
cord-015021-pol2qm74	8288	3	them	-PRON-	PRP
cord-015021-pol2qm74	8288	4	were	be	VBD
cord-015021-pol2qm74	8288	5	in	in	IN
cord-015021-pol2qm74	8288	6	septic	septic	JJ
cord-015021-pol2qm74	8288	7	shock	shock	NN
cord-015021-pol2qm74	8288	8	.	.	.
cord-015021-pol2qm74	8289	1	There	there	EX
cord-015021-pol2qm74	8289	2	was	be	VBD
cord-015021-pol2qm74	8289	3	a	a	DT
cord-015021-pol2qm74	8289	4	significant	significant	JJ
cord-015021-pol2qm74	8289	5	correlation	correlation	NN
cord-015021-pol2qm74	8289	6	between	between	IN
cord-015021-pol2qm74	8289	7	preoperative	preoperative	JJ
cord-015021-pol2qm74	8289	8	TNFa	TNFa	NNS
cord-015021-pol2qm74	8289	9	and	and	CC
cord-015021-pol2qm74	8289	10	APACHE	APACHE	NNP
cord-015021-pol2qm74	8289	11	II	II	NNP
cord-015021-pol2qm74	8290	1	(	(	-LRB-
cord-015021-pol2qm74	8290	2	p=0,000	p=0,000	NNP
cord-015021-pol2qm74	8291	1	I	-PRON-	PRP
cord-015021-pol2qm74	8291	2	,	,	,
cord-015021-pol2qm74	8291	3	Spearman	Spearman	NNP
cord-015021-pol2qm74	8291	4	coefficient	coefficient	NN
cord-015021-pol2qm74	8291	5	)	)	-RRB-
cord-015021-pol2qm74	8291	6	.	.	.
cord-015021-pol2qm74	8292	1	Preoperative	Preoperative	NNP
cord-015021-pol2qm74	8292	2	cardiovascular	cardiovascular	NN
cord-015021-pol2qm74	8292	3	(	(	-LRB-
cord-015021-pol2qm74	8292	4	systol	systol	NNP
cord-015021-pol2qm74	8292	5	.	.	.
cord-015021-pol2qm74	8293	1	RR<90	RR<90	NNP
cord-015021-pol2qm74	8293	2	mmHg	mmHg	NNP
cord-015021-pol2qm74	8293	3	)	)	-RRB-
cord-015021-pol2qm74	8293	4	and	and	CC
cord-015021-pol2qm74	8293	5	respiratory	respiratory	JJ
cord-015021-pol2qm74	8293	6	(	(	-LRB-
cord-015021-pol2qm74	8293	7	PaO2<75	PaO2<75	NNP
cord-015021-pol2qm74	8293	8	mm	mm	CD
cord-015021-pol2qm74	8293	9	Hg	Hg	NNP
cord-015021-pol2qm74	8293	10	)	)	-RRB-
cord-015021-pol2qm74	8293	11	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8293	12	were	be	VBD
cord-015021-pol2qm74	8293	13	associated	associate	VBN
cord-015021-pol2qm74	8293	14	with	with	IN
cord-015021-pol2qm74	8293	15	significantly	significantly	RB
cord-015021-pol2qm74	8293	16	elevated	elevated	JJ
cord-015021-pol2qm74	8293	17	TNFa	TNFa	NNS
cord-015021-pol2qm74	8293	18	(	(	-LRB-
cord-015021-pol2qm74	8293	19	cardial	cardial	NNP
cord-015021-pol2qm74	8293	20	:	:	:
cord-015021-pol2qm74	8293	21	p=0,000	p=0,000	.
cord-015021-pol2qm74	8294	1	I	-PRON-	PRP
cord-015021-pol2qm74	8294	2	,	,	,
cord-015021-pol2qm74	8294	3	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	8294	4	;	;	:
cord-015021-pol2qm74	8294	5	pulmonal	pulmonal	JJ
cord-015021-pol2qm74	8294	6	:	:	:
cord-015021-pol2qm74	8294	7	p=0,0003	p=0,0003	NNP
cord-015021-pol2qm74	8294	8	)	)	-RRB-
cord-015021-pol2qm74	8294	9	and	and	CC
cord-015021-pol2qm74	8295	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	8295	2	(	(	-LRB-
cord-015021-pol2qm74	8295	3	Cardial	Cardial	NNP
cord-015021-pol2qm74	8295	4	:	:	:
cord-015021-pol2qm74	8295	5	p=0,2	p=0,2	JJ
cord-015021-pol2qm74	8295	6	;	;	:
cord-015021-pol2qm74	8295	7	pulmonal	pulmonal	JJ
cord-015021-pol2qm74	8295	8	:	:	:
cord-015021-pol2qm74	8295	9	p=0.0001	p=0.0001	NNS
cord-015021-pol2qm74	8295	10	)	)	-RRB-
cord-015021-pol2qm74	8296	1	Overall	overall	RB
cord-015021-pol2qm74	8296	2	,	,	,
cord-015021-pol2qm74	8296	3	LPS	LPS	NNP
cord-015021-pol2qm74	8296	4	,	,	,
cord-015021-pol2qm74	8296	5	TNFa	TNFa	NNS
cord-015021-pol2qm74	8296	6	and	and	CC
cord-015021-pol2qm74	8296	7	IL-6	IL-6	NNP
cord-015021-pol2qm74	8296	8	values	value	NNS
cord-015021-pol2qm74	8296	9	varied	vary	VBN
cord-015021-pol2qm74	8296	10	considerably	considerably	RB
cord-015021-pol2qm74	8296	11	during	during	IN
cord-015021-pol2qm74	8296	12	the	the	DT
cord-015021-pol2qm74	8296	13	observation	observation	NN
cord-015021-pol2qm74	8296	14	period	period	NN
cord-015021-pol2qm74	8296	15	.	.	.
cord-015021-pol2qm74	8297	1	However	however	RB
cord-015021-pol2qm74	8297	2	,	,	,
cord-015021-pol2qm74	8297	3	TNFa	TNFa	NNP
cord-015021-pol2qm74	8297	4	was	be	VBD
cord-015021-pol2qm74	8297	5	markedly	markedly	RB
cord-015021-pol2qm74	8297	6	higher	high	JJR
cord-015021-pol2qm74	8297	7	in	in	IN
cord-015021-pol2qm74	8297	8	patients	patient	NNS
cord-015021-pol2qm74	8297	9	with	with	IN
cord-015021-pol2qm74	8297	10	SIRS	SIRS	NNP
cord-015021-pol2qm74	8297	11	and	and	CC
cord-015021-pol2qm74	8297	12	septic	septic	JJ
cord-015021-pol2qm74	8297	13	shock	shock	NN
cord-015021-pol2qm74	8297	14	(	(	-LRB-
cord-015021-pol2qm74	8297	15	group	group	NN
cord-015021-pol2qm74	8297	16	A	a	NN
cord-015021-pol2qm74	8297	17	:	:	:
cord-015021-pol2qm74	8298	1	n=	n=	NNP
cord-015021-pol2qm74	8298	2	I	I	NNP
cord-015021-pol2qm74	8298	3	0	0	CD
cord-015021-pol2qm74	8298	4	,	,	,
cord-015021-pol2qm74	8299	1	mean	mean	VB
cord-015021-pol2qm74	8299	2	182	182	CD
cord-015021-pol2qm74	8299	3	pg	pg	NN
cord-015021-pol2qm74	8299	4	/	/	SYM
cord-015021-pol2qm74	8299	5	ml	ml	NN
cord-015021-pol2qm74	8299	6	)	)	-RRB-
cord-015021-pol2qm74	8300	1	than	than	IN
cord-015021-pol2qm74	8300	2	in	in	IN
cord-015021-pol2qm74	8300	3	those	those	DT
cord-015021-pol2qm74	8300	4	who	who	WP
cord-015021-pol2qm74	8300	5	did	do	VBD
cord-015021-pol2qm74	8300	6	not	not	RB
cord-015021-pol2qm74	8300	7	fulfill	fulfill	VB
cord-015021-pol2qm74	8300	8	these	these	DT
cord-015021-pol2qm74	8300	9	criteria	criterion	NNS
cord-015021-pol2qm74	8300	10	(	(	-LRB-
cord-015021-pol2qm74	8300	11	group	group	NN
cord-015021-pol2qm74	8300	12	B	B	NNP
cord-015021-pol2qm74	8300	13	;	;	:
cord-015021-pol2qm74	8300	14	n=9	n=9	NN
cord-015021-pol2qm74	8300	15	,	,	,
cord-015021-pol2qm74	8300	16	mean	mean	VB
cord-015021-pol2qm74	8300	17	24	24	CD
cord-015021-pol2qm74	8300	18	pg	pg	NN
cord-015021-pol2qm74	8300	19	/	/	SYM
cord-015021-pol2qm74	8300	20	ml	ml	NN
cord-015021-pol2qm74	8300	21	;	;	:
cord-015021-pol2qm74	8301	1	p=0,00	p=0,00	NNP
cord-015021-pol2qm74	8302	1	I	-PRON-	PRP
cord-015021-pol2qm74	8302	2	,	,	,
cord-015021-pol2qm74	8302	3	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	8302	4	)	)	-RRB-
cord-015021-pol2qm74	8302	5	.	.	.
cord-015021-pol2qm74	8303	1	IL-6	IL-6	NNP
cord-015021-pol2qm74	8303	2	was	be	VBD
cord-015021-pol2qm74	8303	3	significantly	significantly	RB
cord-015021-pol2qm74	8303	4	higher	high	JJR
cord-015021-pol2qm74	8303	5	in	in	IN
cord-015021-pol2qm74	8303	6	group	group	NN
cord-015021-pol2qm74	8303	7	A	A	NNP
cord-015021-pol2qm74	8303	8	(	(	-LRB-
cord-015021-pol2qm74	8303	9	mean	mean	JJ
cord-015021-pol2qm74	8303	10	2169	2169	CD
cord-015021-pol2qm74	8303	11	pg	pg	NN
cord-015021-pol2qm74	8303	12	/	/	SYM
cord-015021-pol2qm74	8303	13	ml	ml	NNP
cord-015021-pol2qm74	8303	14	)	)	-RRB-
cord-015021-pol2qm74	8303	15	than	than	IN
cord-015021-pol2qm74	8303	16	in	in	IN
cord-015021-pol2qm74	8303	17	group	group	NN
cord-015021-pol2qm74	8303	18	B	B	NNP
cord-015021-pol2qm74	8303	19	(	(	-LRB-
cord-015021-pol2qm74	8303	20	mean	mean	VB
cord-015021-pol2qm74	8303	21	191	191	CD
cord-015021-pol2qm74	8303	22	pg	pg	NN
cord-015021-pol2qm74	8303	23	/	/	SYM
cord-015021-pol2qm74	8303	24	ml	ml	NN
cord-015021-pol2qm74	8303	25	;	;	:
cord-015021-pol2qm74	8304	1	p=0,0O	p=0,0O	NNP
cord-015021-pol2qm74	8304	2	I	I	NNP
cord-015021-pol2qm74	8304	3	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	8304	4	)	)	-RRB-
cord-015021-pol2qm74	8304	5	.	.	.
cord-015021-pol2qm74	8305	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	8305	2	:	:	:
cord-015021-pol2qm74	8306	1	Perioperative	Perioperative	NNP
cord-015021-pol2qm74	8306	2	TNFa	TNFa	NNP
cord-015021-pol2qm74	8306	3	and	and	CC
cord-015021-pol2qm74	8306	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	8306	5	were	be	VBD
cord-015021-pol2qm74	8306	6	shown	show	VBN
cord-015021-pol2qm74	8306	7	to	to	TO
cord-015021-pol2qm74	8306	8	correlate	correlate	VB
cord-015021-pol2qm74	8306	9	significantly	significantly	RB
cord-015021-pol2qm74	8306	10	with	with	IN
cord-015021-pol2qm74	8306	11	preoperative	preoperative	JJ
cord-015021-pol2qm74	8306	12	organ	organ	NN
cord-015021-pol2qm74	8306	13	function	function	NN
cord-015021-pol2qm74	8306	14	,	,	,
cord-015021-pol2qm74	8306	15	APACHE	APACHE	NNP
cord-015021-pol2qm74	8306	16	II	II	NNP
cord-015021-pol2qm74	8306	17	and	and	CC
cord-015021-pol2qm74	8306	18	the	the	DT
cord-015021-pol2qm74	8306	19	severity	severity	NN
cord-015021-pol2qm74	8306	20	of	of	IN
cord-015021-pol2qm74	8306	21	sepsis	sepsis	NN
cord-015021-pol2qm74	8306	22	.	.	.
cord-015021-pol2qm74	8307	1	These	these	DT
cord-015021-pol2qm74	8307	2	results	result	NNS
cord-015021-pol2qm74	8307	3	could	could	MD
cord-015021-pol2qm74	8307	4	help	help	VB
cord-015021-pol2qm74	8307	5	to	to	TO
cord-015021-pol2qm74	8307	6	define	define	VB
cord-015021-pol2qm74	8307	7	patients	patient	NNS
cord-015021-pol2qm74	8307	8	that	that	WDT
cord-015021-pol2qm74	8307	9	might	may	MD
cord-015021-pol2qm74	8307	10	benefit	benefit	VB
cord-015021-pol2qm74	8307	11	from	from	IN
cord-015021-pol2qm74	8307	12	further	further	JJ
cord-015021-pol2qm74	8307	13	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8307	14	strategies	strategy	NNS
cord-015021-pol2qm74	8307	15	,	,	,
cord-015021-pol2qm74	8307	16	e.g.	e.g.	DT
cord-015021-pol2qm74	8307	17	antibody	antibody	NN
cord-015021-pol2qm74	8307	18	administration	administration	NN
cord-015021-pol2qm74	8307	19	.	.	.
cord-015021-pol2qm74	8308	1	Department	Department	NNP
cord-015021-pol2qm74	8308	2	of	of	IN
cord-015021-pol2qm74	8308	3	Surgery	Surgery	NNP
cord-015021-pol2qm74	8308	4	,	,	,
cord-015021-pol2qm74	8308	5	University	University	NNP
cord-015021-pol2qm74	8308	6	Vienna	Vienna	NNP
cord-015021-pol2qm74	8308	7	,	,	,
cord-015021-pol2qm74	8308	8	AKH	AKH	NNP
cord-015021-pol2qm74	8308	9	Wien	Wien	NNP
cord-015021-pol2qm74	8308	10	,	,	,
cord-015021-pol2qm74	8308	11	Wahringer	Wahringer	NNP
cord-015021-pol2qm74	8308	12	Gurtel	Gurtel	NNP
cord-015021-pol2qm74	8308	13	18	18	CD
cord-015021-pol2qm74	8308	14	-	-	SYM
cord-015021-pol2qm74	8308	15	20	20	CD
cord-015021-pol2qm74	8308	16	,	,	,
cord-015021-pol2qm74	8308	17	1090	1090	CD
cord-015021-pol2qm74	8308	18	Wien	Wien	NNP
cord-015021-pol2qm74	8308	19	.	.	.
cord-015021-pol2qm74	8309	1	Aim	Aim	NNP
cord-015021-pol2qm74	8309	2	of	of	IN
cord-015021-pol2qm74	8309	3	the	the	DT
cord-015021-pol2qm74	8309	4	study	study	NN
cord-015021-pol2qm74	8309	5	:	:	:
cord-015021-pol2qm74	8309	6	The	the	DT
cord-015021-pol2qm74	8309	7	purpose	purpose	NN
cord-015021-pol2qm74	8309	8	of	of	IN
cord-015021-pol2qm74	8309	9	this	this	DT
cord-015021-pol2qm74	8309	10	pilot	pilot	NN
cord-015021-pol2qm74	8309	11	study	study	NN
cord-015021-pol2qm74	8309	12	was	be	VBD
cord-015021-pol2qm74	8309	13	to	to	TO
cord-015021-pol2qm74	8309	14	establish	establish	VB
cord-015021-pol2qm74	8309	15	and	and	CC
cord-015021-pol2qm74	8309	16	to	to	TO
cord-015021-pol2qm74	8309	17	prove	prove	VB
cord-015021-pol2qm74	8309	18	a	a	DT
cord-015021-pol2qm74	8309	19	standardized	standardized	JJ
cord-015021-pol2qm74	8309	20	reproducible	reproducible	JJ
cord-015021-pol2qm74	8309	21	animal	animal	NN
cord-015021-pol2qm74	8309	22	model	model	NN
cord-015021-pol2qm74	8309	23	of	of	IN
cord-015021-pol2qm74	8309	24	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	8309	25	sepsis	sepsis	NN
cord-015021-pol2qm74	8309	26	induced	induce	VBN
cord-015021-pol2qm74	8309	27	by	by	IN
cord-015021-pol2qm74	8309	28	E.coli	e.coli	NN
cord-015021-pol2qm74	8309	29	-	-	HYPH
cord-015021-pol2qm74	8309	30	endotoxinaemia	endotoxinaemia	NN
cord-015021-pol2qm74	8309	31	in	in	IN
cord-015021-pol2qm74	8309	32	LEW.lW	lew.lw	NN
cord-015021-pol2qm74	8309	33	-	-	HYPH
cord-015021-pol2qm74	8309	34	rats	rat	NNS
cord-015021-pol2qm74	8309	35	in	in	IN
cord-015021-pol2qm74	8309	36	order	order	NN
cord-015021-pol2qm74	8309	37	to	to	TO
cord-015021-pol2qm74	8309	38	investigate	investigate	VB
cord-015021-pol2qm74	8309	39	early	early	JJ
cord-015021-pol2qm74	8309	40	immunoserological	immunoserological	JJ
cord-015021-pol2qm74	8309	41	responses	response	NNS
cord-015021-pol2qm74	8309	42	to	to	TO
cord-015021-pol2qm74	8309	43	find	find	VB
cord-015021-pol2qm74	8309	44	a	a	DT
cord-015021-pol2qm74	8309	45	mediator	mediator	NN
cord-015021-pol2qm74	8309	46	based	base	VBN
cord-015021-pol2qm74	8309	47	evaluating	evaluate	VBG
cord-015021-pol2qm74	8309	48	system	system	NN
cord-015021-pol2qm74	8309	49	of	of	IN
cord-015021-pol2qm74	8309	50	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8309	51	sepsis	sepsis	NN
cord-015021-pol2qm74	8309	52	.	.	.
cord-015021-pol2qm74	8310	1	Materials	material	NNS
cord-015021-pol2qm74	8310	2	and	and	CC
cord-015021-pol2qm74	8310	3	methods	method	NNS
cord-015021-pol2qm74	8310	4	:	:	:
cord-015021-pol2qm74	8310	5	In	in	IN
cord-015021-pol2qm74	8310	6	30	30	CD
cord-015021-pol2qm74	8310	7	LEW	LEW	NNP
cord-015021-pol2qm74	8310	8	.	.	.
cord-015021-pol2qm74	8311	1	lW	lw	LS
cord-015021-pol2qm74	8311	2	-	-	HYPH
cord-015021-pol2qm74	8311	3	rats	rat	NNS
cord-015021-pol2qm74	8311	4	,	,	,
cord-015021-pol2qm74	8311	5	diffuse	diffuse	JJ
cord-015021-pol2qm74	8311	6	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8311	7	was	be	VBD
cord-015021-pol2qm74	8311	8	induced	induce	VBN
cord-015021-pol2qm74	8311	9	by	by	IN
cord-015021-pol2qm74	8311	10	intraperitoneal	intraperitoneal	JJ
cord-015021-pol2qm74	8311	11	injection	injection	NN
cord-015021-pol2qm74	8311	12	of	of	IN
cord-015021-pol2qm74	8311	13	a	a	DT
cord-015021-pol2qm74	8311	14	mixture	mixture	NN
cord-015021-pol2qm74	8311	15	of	of	IN
cord-015021-pol2qm74	8311	16	E.coli	E.coli	NNS
cord-015021-pol2qm74	8311	17	(	(	-LRB-
cord-015021-pol2qm74	8311	18	KhU	KhU	NNP
cord-015021-pol2qm74	8311	19	+	+	SYM
cord-015021-pol2qm74	8311	20	)	)	-RRB-
cord-015021-pol2qm74	8311	21	and	and	CC
cord-015021-pol2qm74	8311	22	autogenous	autogenous	JJ
cord-015021-pol2qm74	8311	23	haemoglobin	haemoglobin	NN
cord-015021-pol2qm74	8311	24	solution	solution	NN
cord-015021-pol2qm74	8311	25	.	.	.
cord-015021-pol2qm74	8312	1	In	in	IN
cord-015021-pol2qm74	8312	2	the	the	DT
cord-015021-pol2qm74	8312	3	control	control	NN
cord-015021-pol2qm74	8312	4	animal	animal	NN
cord-015021-pol2qm74	8312	5	group	group	NN
cord-015021-pol2qm74	8312	6	(	(	-LRB-
cord-015021-pol2qm74	8312	7	n=	n=	NNP
cord-015021-pol2qm74	8312	8	12	12	CD
cord-015021-pol2qm74	8312	9	)	)	-RRB-
cord-015021-pol2qm74	8312	10	an	an	DT
cord-015021-pol2qm74	8312	11	intraperitoneally	intraperitoneally	NN
cord-015021-pol2qm74	8312	12	injection	injection	NN
cord-015021-pol2qm74	8312	13	of	of	IN
cord-015021-pol2qm74	8312	14	physiological	physiological	JJ
cord-015021-pol2qm74	8312	15	saline	saline	NN
cord-015021-pol2qm74	8312	16	solution	solution	NN
cord-015021-pol2qm74	8312	17	was	be	VBD
cord-015021-pol2qm74	8312	18	done	do	VBN
cord-015021-pol2qm74	8312	19	.	.	.
cord-015021-pol2qm74	8313	1	Blood	blood	NN
cord-015021-pol2qm74	8313	2	samples	sample	NNS
cord-015021-pol2qm74	8313	3	were	be	VBD
cord-015021-pol2qm74	8313	4	obtained	obtain	VBN
cord-015021-pol2qm74	8313	5	by	by	IN
cord-015021-pol2qm74	8313	6	heart	heart	NN
cord-015021-pol2qm74	8313	7	puncture	puncture	NN
cord-015021-pol2qm74	8313	8	after	after	IN
cord-015021-pol2qm74	8313	9	6	6	CD
cord-015021-pol2qm74	8313	10	hours	hour	NNS
cord-015021-pol2qm74	8313	11	.	.	.
cord-015021-pol2qm74	8314	1	Stastistieal	stastistieal	JJ
cord-015021-pol2qm74	8314	2	calculations	calculation	NNS
cord-015021-pol2qm74	8314	3	were	be	VBD
cord-015021-pol2qm74	8314	4	performed	perform	VBN
cord-015021-pol2qm74	8314	5	on	on	IN
cord-015021-pol2qm74	8314	6	a	a	DT
cord-015021-pol2qm74	8314	7	personal	personal	JJ
cord-015021-pol2qm74	8314	8	computer	computer	NN
cord-015021-pol2qm74	8314	9	with	with	IN
cord-015021-pol2qm74	8314	10	the	the	DT
cord-015021-pol2qm74	8314	11	SPSS	SPSS	NNP
cord-015021-pol2qm74	8314	12	programm	programm	NNP
cord-015021-pol2qm74	8314	13	Vers	Vers	NNP
cord-015021-pol2qm74	8314	14	.	.	.
cord-015021-pol2qm74	8315	1	4.01	4.01	CD
cord-015021-pol2qm74	8316	1	(	(	-LRB-
cord-015021-pol2qm74	8316	2	correlation	correlation	NN
cord-015021-pol2qm74	8316	3	with	with	IN
cord-015021-pol2qm74	8316	4	Pearson	Pearson	NNP
cord-015021-pol2qm74	8316	5	's	's	POS
cord-015021-pol2qm74	8316	6	R	r	NN
cord-015021-pol2qm74	8316	7	,	,	,
cord-015021-pol2qm74	8316	8	Mann	Mann	NNP
cord-015021-pol2qm74	8316	9	-	-	HYPH
cord-015021-pol2qm74	8316	10	Whitney	Whitney	NNP
cord-015021-pol2qm74	8316	11	-	-	HYPH
cord-015021-pol2qm74	8316	12	U	U	NNP
cord-015021-pol2qm74	8316	13	-	-	HYPH
cord-015021-pol2qm74	8316	14	Test	test	NN
cord-015021-pol2qm74	8316	15	,	,	,
cord-015021-pol2qm74	8316	16	descriptives	descriptive	NNS
cord-015021-pol2qm74	8316	17	statistics	statistic	NNS
cord-015021-pol2qm74	8316	18	,	,	,
cord-015021-pol2qm74	8316	19	discriminant	discriminant	NN
cord-015021-pol2qm74	8316	20	analysis	analysis	NN
cord-015021-pol2qm74	8316	21	)	)	-RRB-
cord-015021-pol2qm74	8316	22	.	.	.
cord-015021-pol2qm74	8317	1	Results	result	NNS
cord-015021-pol2qm74	8317	2	:	:	:
cord-015021-pol2qm74	8318	1	In	in	IN
cord-015021-pol2qm74	8318	2	contrast	contrast	NN
cord-015021-pol2qm74	8318	3	to	to	IN
cord-015021-pol2qm74	8318	4	the	the	DT
cord-015021-pol2qm74	8318	5	sham	sham	NN
cord-015021-pol2qm74	8318	6	treated	treat	VBN
cord-015021-pol2qm74	8318	7	rats	rat	NNS
cord-015021-pol2qm74	8318	8	,	,	,
cord-015021-pol2qm74	8318	9	the	the	DT
cord-015021-pol2qm74	8318	10	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8318	11	animals	animal	NNS
cord-015021-pol2qm74	8318	12	showed	show	VBD
cord-015021-pol2qm74	8318	13	significant	significant	JJ
cord-015021-pol2qm74	8318	14	differences	difference	NNS
cord-015021-pol2qm74	8318	15	in	in	IN
cord-015021-pol2qm74	8318	16	the	the	DT
cord-015021-pol2qm74	8318	17	concentrations	concentration	NNS
cord-015021-pol2qm74	8318	18	of	of	IN
cord-015021-pol2qm74	8318	19	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8318	20	,	,	,
cord-015021-pol2qm74	8318	21	interferon	interferon	NN
cord-015021-pol2qm74	8318	22	-	-	HYPH
cord-015021-pol2qm74	8318	23	gamma	gamma	NN
cord-015021-pol2qm74	8318	24	(	(	-LRB-
cord-015021-pol2qm74	8318	25	WN	WN	NNP
cord-015021-pol2qm74	8318	26	-	-	HYPH
cord-015021-pol2qm74	8318	27	y	y	NNP
cord-015021-pol2qm74	8318	28	)	)	-RRB-
cord-015021-pol2qm74	8318	29	,	,	,
cord-015021-pol2qm74	8318	30	the	the	DT
cord-015021-pol2qm74	8318	31	pteridin	pteridin	NNP
cord-015021-pol2qm74	8318	32	derivate	derivate	NNP
cord-015021-pol2qm74	8318	33	biopterin	biopterin	NNP
cord-015021-pol2qm74	8318	34	and	and	CC
cord-015021-pol2qm74	8318	35	serum	serum	NN
cord-015021-pol2qm74	8318	36	PLA2-activities	pla2-activitie	NNS
cord-015021-pol2qm74	8319	1	[	[	-LRB-
cord-015021-pol2qm74	8319	2	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8319	3	range	range	NN
cord-015021-pol2qm74	8319	4	from	from	IN
cord-015021-pol2qm74	8319	5	0.064	0.064	CD
cord-015021-pol2qm74	8319	6	EU	EU	NNP
cord-015021-pol2qm74	8319	7	/	/	SYM
cord-015021-pol2qm74	8319	8	I	i	NN
cord-015021-pol2qm74	8319	9	,	,	,
cord-015021-pol2qm74	8319	10	SD=0.19	SD=0.19	VBZ
cord-015021-pol2qm74	8319	11	to	to	IN
cord-015021-pol2qm74	8319	12	102.38	102.38	CD
cord-015021-pol2qm74	8319	13	EU/1	EU/1	NNP
cord-015021-pol2qm74	8319	14	,	,	,
cord-015021-pol2qm74	8320	1	SD-145.4	SD-145.4	NNP
cord-015021-pol2qm74	8321	1	(	(	-LRB-
cord-015021-pol2qm74	8321	2	p	p	NN
cord-015021-pol2qm74	8321	3	<	<	XX
cord-015021-pol2qm74	8321	4	0	0	CD
cord-015021-pol2qm74	8321	5	0001	0001	CD
cord-015021-pol2qm74	8321	6	)	)	-RRB-
cord-015021-pol2qm74	8321	7	,	,	,
cord-015021-pol2qm74	8321	8	IFN-¥	ifn-¥	CD
cord-015021-pol2qm74	8321	9	levels	level	NNS
cord-015021-pol2qm74	8321	10	,	,	,
cord-015021-pol2qm74	8321	11	range	range	VBP
cord-015021-pol2qm74	8321	12	from	from	IN
cord-015021-pol2qm74	8321	13	147.9	147.9	CD
cord-015021-pol2qm74	8321	14	pg	pg	NN
cord-015021-pol2qm74	8321	15	/	/	SYM
cord-015021-pol2qm74	8321	16	ml	ml	NNS
cord-015021-pol2qm74	8321	17	,	,	,
cord-015021-pol2qm74	8321	18	SD-141.6	SD-141.6	NNPS
cord-015021-pol2qm74	8321	19	,	,	,
cord-015021-pol2qm74	8321	20	to	to	IN
cord-015021-pol2qm74	8321	21	4591	4591	CD
cord-015021-pol2qm74	8321	22	pg	pg	NNP
cord-015021-pol2qm74	8321	23	/	/	SYM
cord-015021-pol2qm74	8321	24	ml	ml	NNP
cord-015021-pol2qm74	8321	25	,	,	,
cord-015021-pol2qm74	8321	26	SD=6541	SD=6541	NNP
cord-015021-pol2qm74	8322	1	(	(	-LRB-
cord-015021-pol2qm74	8322	2	p	p	NN
cord-015021-pol2qm74	8322	3	<	<	XX
cord-015021-pol2qm74	8322	4	0.0001	0.0001	CD
cord-015021-pol2qm74	8322	5	)	)	-RRB-
cord-015021-pol2qm74	8322	6	,	,	,
cord-015021-pol2qm74	8322	7	circulating	circulate	VBG
cord-015021-pol2qm74	8322	8	PLA2-activities	pla2-activitie	NNS
cord-015021-pol2qm74	8322	9	range	range	VBP
cord-015021-pol2qm74	8322	10	from	from	IN
cord-015021-pol2qm74	8322	11	116.2	116.2	CD
cord-015021-pol2qm74	8322	12	,	,	,
cord-015021-pol2qm74	8323	1	SD=45.4	sd=45.4	VB
cord-015021-pol2qm74	8323	2	to	to	IN
cord-015021-pol2qm74	8323	3	185.4	185.4	CD
cord-015021-pol2qm74	8323	4	U/1	u/1	NN
cord-015021-pol2qm74	8323	5	,	,	,
cord-015021-pol2qm74	8323	6	SD=105.4	SD=105.4	NNP
cord-015021-pol2qm74	8323	7	(	(	-LRB-
cord-015021-pol2qm74	8323	8	p	p	NN
cord-015021-pol2qm74	8323	9	<	<	XX
cord-015021-pol2qm74	8323	10	0.01	0.01	CD
cord-015021-pol2qm74	8323	11	)	)	-RRB-
cord-015021-pol2qm74	8324	1	and	and	CC
cord-015021-pol2qm74	8324	2	biopterin	biopterin	NNP
cord-015021-pol2qm74	8324	3	range	range	NN
cord-015021-pol2qm74	8324	4	from	from	IN
cord-015021-pol2qm74	8324	5	54.4	54.4	CD
cord-015021-pol2qm74	8324	6	nmol	nmol	NNP
cord-015021-pol2qm74	8324	7	/	/	SYM
cord-015021-pol2qm74	8324	8	l	l	NNP
cord-015021-pol2qm74	8324	9	SD=17.2	SD=17.2	NNP
cord-015021-pol2qm74	8324	10	to	to	IN
cord-015021-pol2qm74	8324	11	127.8	127.8	CD
cord-015021-pol2qm74	8324	12	nmol	nmol	NNP
cord-015021-pol2qm74	8324	13	/	/	SYM
cord-015021-pol2qm74	8324	14	l	l	NN
cord-015021-pol2qm74	8324	15	,	,	,
cord-015021-pol2qm74	8324	16	SD=76.8	SD=76.8	NNP
cord-015021-pol2qm74	8324	17	(	(	-LRB-
cord-015021-pol2qm74	8324	18	p	p	NN
cord-015021-pol2qm74	8324	19	<	<	XX
cord-015021-pol2qm74	8324	20	0.001	0.001	CD
cord-015021-pol2qm74	8324	21	)	)	-RRB-
cord-015021-pol2qm74	8324	22	]	]	-RRB-
cord-015021-pol2qm74	8324	23	.	.	.
cord-015021-pol2qm74	8325	1	For	for	IN
cord-015021-pol2qm74	8325	2	the	the	DT
cord-015021-pol2qm74	8325	3	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8325	4	group	group	NN
cord-015021-pol2qm74	8325	5	we	-PRON-	PRP
cord-015021-pol2qm74	8325	6	found	find	VBD
cord-015021-pol2qm74	8325	7	strong	strong	JJ
cord-015021-pol2qm74	8325	8	correlations	correlation	NNS
cord-015021-pol2qm74	8325	9	between	between	IN
cord-015021-pol2qm74	8325	10	the	the	DT
cord-015021-pol2qm74	8325	11	degree	degree	NN
cord-015021-pol2qm74	8325	12	of	of	IN
cord-015021-pol2qm74	8325	13	endotoxinaemia	endotoxinaemia	NN
cord-015021-pol2qm74	8325	14	to	to	IN
cord-015021-pol2qm74	8325	15	elevated	elevated	JJ
cord-015021-pol2qm74	8325	16	levels	level	NNS
cord-015021-pol2qm74	8325	17	of	of	IN
cord-015021-pol2qm74	8325	18	IFN-'~	IFN-'~	NNP
cord-015021-pol2qm74	8325	19	(	(	-LRB-
cord-015021-pol2qm74	8325	20	rp	rp	NN
cord-015021-pol2qm74	8325	21	=	=	NN
cord-015021-pol2qm74	8325	22	0.72	0.72	CD
cord-015021-pol2qm74	8325	23	,	,	,
cord-015021-pol2qm74	8325	24	p	p	NN
cord-015021-pol2qm74	8325	25	<	<	XX
cord-015021-pol2qm74	8325	26	0.0001	0.0001	CD
cord-015021-pol2qm74	8325	27	)	)	-RRB-
cord-015021-pol2qm74	8325	28	and	and	CC
cord-015021-pol2qm74	8325	29	bioptefin	bioptefin	NNP
cord-015021-pol2qm74	8325	30	synthesis	synthesis	NNP
cord-015021-pol2qm74	8325	31	(	(	-LRB-
cord-015021-pol2qm74	8325	32	rv=	rv=	NNP
cord-015021-pol2qm74	8325	33	0.82	0.82	CD
cord-015021-pol2qm74	8325	34	,	,	,
cord-015021-pol2qm74	8325	35	p	p	NN
cord-015021-pol2qm74	8325	36	<	<	XX
cord-015021-pol2qm74	8325	37	0.0001	0.0001	CD
cord-015021-pol2qm74	8325	38	)	)	-RRB-
cord-015021-pol2qm74	8325	39	.	.	.
cord-015021-pol2qm74	8326	1	The	the	DT
cord-015021-pol2qm74	8326	2	increase	increase	NN
cord-015021-pol2qm74	8326	3	of	of	IN
cord-015021-pol2qm74	8326	4	IFN	IFN	NNP
cord-015021-pol2qm74	8326	5	-	-	HYPH
cord-015021-pol2qm74	8326	6	T	T	NNP
cord-015021-pol2qm74	8326	7	levels	level	NNS
cord-015021-pol2qm74	8326	8	was	be	VBD
cord-015021-pol2qm74	8326	9	correlated	correlate	VBN
cord-015021-pol2qm74	8326	10	to	to	IN
cord-015021-pol2qm74	8326	11	the	the	DT
cord-015021-pol2qm74	8326	12	regulatory	regulatory	JJ
cord-015021-pol2qm74	8326	13	synthesis	synthesis	NN
cord-015021-pol2qm74	8326	14	of	of	IN
cord-015021-pol2qm74	8326	15	biopterin	biopterin	NNP
cord-015021-pol2qm74	8326	16	(	(	-LRB-
cord-015021-pol2qm74	8326	17	r	r	NN
cord-015021-pol2qm74	8326	18	=	=	NN
cord-015021-pol2qm74	8326	19	0	0	CD
cord-015021-pol2qm74	8326	20	73	73	CD
cord-015021-pol2qm74	8326	21	p	p	NN
cord-015021-pol2qm74	8326	22	<	<	XX
cord-015021-pol2qm74	8326	23	.	.	.
cord-015021-pol2qm74	8327	1	..	..	.
cord-015021-pol2qm74	8328	1	P	p	NN
cord-015021-pol2qm74	8328	2	•	•	NN
cord-015021-pol2qm74	8328	3	,	,	,
cord-015021-pol2qm74	8328	4	.	.	.
cord-015021-pol2qm74	8329	1	0.0001	0.0001	LS
cord-015021-pol2qm74	8329	2	)	)	-RRB-
cord-015021-pol2qm74	8329	3	and	and	CC
cord-015021-pol2qm74	8329	4	to	to	IN
cord-015021-pol2qm74	8329	5	the	the	DT
cord-015021-pol2qm74	8329	6	PLA2-actwtUes	pla2-actwtues	NN
cord-015021-pol2qm74	8329	7	(	(	-LRB-
cord-015021-pol2qm74	8329	8	rp	rp	NN
cord-015021-pol2qm74	8329	9	=	=	NN
cord-015021-pol2qm74	8329	10	0.50	0.50	CD
cord-015021-pol2qm74	8329	11	,	,	,
cord-015021-pol2qm74	8329	12	p	p	NN
cord-015021-pol2qm74	8329	13	<	<	XX
cord-015021-pol2qm74	8329	14	0.005	0.005	CD
cord-015021-pol2qm74	8329	15	)	)	-RRB-
cord-015021-pol2qm74	8329	16	.	.	.
cord-015021-pol2qm74	8330	1	The	the	DT
cord-015021-pol2qm74	8330	2	biopterin	biopterin	NNP
cord-015021-pol2qm74	8330	3	synthes	synthe	NNS
cord-015021-pol2qm74	8331	1	~s	~s	NNP
cord-015021-pol2qm74	8331	2	correlates	correlate	VBZ
cord-015021-pol2qm74	8331	3	slightly	slightly	RB
cord-015021-pol2qm74	8331	4	with	with	IN
cord-015021-pol2qm74	8331	5	the	the	DT
cord-015021-pol2qm74	8331	6	PLA2-actn	PLA2-actn	NNP
cord-015021-pol2qm74	8331	7	,	,	,
cord-015021-pol2qm74	8331	8	ities	itie	NNS
cord-015021-pol2qm74	8331	9	(	(	-LRB-
cord-015021-pol2qm74	8331	10	rp=	rp=	NNP
cord-015021-pol2qm74	8331	11	:	:	:
cord-015021-pol2qm74	8331	12	0.38	0.38	CD
cord-015021-pol2qm74	8331	13	;	;	.
cord-015021-pol2qm74	8332	1	p	p	NN
cord-015021-pol2qm74	8332	2	<	<	XX
cord-015021-pol2qm74	8332	3	0.05	0.05	CD
cord-015021-pol2qm74	8332	4	)	)	-RRB-
cord-015021-pol2qm74	8332	5	.	.	.
cord-015021-pol2qm74	8333	1	Using	use	VBG
cord-015021-pol2qm74	8333	2	the	the	DT
cord-015021-pol2qm74	8333	3	para	para	NNP
cord-015021-pol2qm74	8333	4	,	,	,
cord-015021-pol2qm74	8333	5	meters	meter	NNS
cord-015021-pol2qm74	8333	6	of	of	IN
cord-015021-pol2qm74	8333	7	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8333	8	,	,	,
cord-015021-pol2qm74	8333	9	IFN	IFN	NNP
cord-015021-pol2qm74	8333	10	-	-	HYPH
cord-015021-pol2qm74	8333	11	y	y	NNP
cord-015021-pol2qm74	8333	12	levels	level	NNS
cord-015021-pol2qm74	8333	13	,	,	,
cord-015021-pol2qm74	8333	14	biopterin	biopterin	NNP
cord-015021-pol2qm74	8333	15	and	and	CC
cord-015021-pol2qm74	8333	16	the	the	DT
cord-015021-pol2qm74	8333	17	PLA~	PLA~	NNP
cord-015021-pol2qm74	8333	18	-activities	-activities	NNP
cord-015021-pol2qm74	8333	19	only	only	RB
cord-015021-pol2qm74	8333	20	,	,	,
cord-015021-pol2qm74	8333	21	the	the	DT
cord-015021-pol2qm74	8333	22	statistical	statistical	JJ
cord-015021-pol2qm74	8333	23	procedure	procedure	NN
cord-015021-pol2qm74	8333	24	of	of	IN
cord-015021-pol2qm74	8333	25	the	the	DT
cord-015021-pol2qm74	8333	26	linear	linear	JJ
cord-015021-pol2qm74	8333	27	discriminant	discriminant	NN
cord-015021-pol2qm74	8333	28	analysis	analysis	NN
cord-015021-pol2qm74	8333	29	makes	make	VBZ
cord-015021-pol2qm74	8333	30	it	-PRON-	PRP
cord-015021-pol2qm74	8333	31	possible	possible	JJ
cord-015021-pol2qm74	8333	32	,	,	,
cord-015021-pol2qm74	8333	33	to	to	TO
cord-015021-pol2qm74	8333	34	distinguish	distinguish	VB
cord-015021-pol2qm74	8333	35	between	between	IN
cord-015021-pol2qm74	8333	36	non	non	JJ
cord-015021-pol2qm74	8333	37	-	-	JJ
cord-015021-pol2qm74	8333	38	septic	septic	JJ
cord-015021-pol2qm74	8333	39	animals	animal	NNS
cord-015021-pol2qm74	8333	40	and	and	CC
cord-015021-pol2qm74	8333	41	septic	septic	JJ
cord-015021-pol2qm74	8333	42	animals	animal	NNS
cord-015021-pol2qm74	8333	43	correctly	correctly	RB
cord-015021-pol2qm74	8333	44	at	at	IN
cord-015021-pol2qm74	8333	45	a	a	DT
cord-015021-pol2qm74	8333	46	rate	rate	NN
cord-015021-pol2qm74	8333	47	of	of	IN
cord-015021-pol2qm74	8333	48	87	87	CD
cord-015021-pol2qm74	8333	49	%	%	NN
cord-015021-pol2qm74	8333	50	.	.	.
cord-015021-pol2qm74	8334	1	Anaerobes	Anaerobes	NNPS
cord-015021-pol2qm74	8334	2	were	be	VBD
cord-015021-pol2qm74	8334	3	found	find	VBN
cord-015021-pol2qm74	8334	4	in	in	IN
cord-015021-pol2qm74	8334	5	53.4	53.4	CD
cord-015021-pol2qm74	8334	6	%	%	NN
cord-015021-pol2qm74	8334	7	,	,	,
cord-015021-pol2qm74	8334	8	anaerobes	anaerobe	NNS
cord-015021-pol2qm74	8334	9	were	be	VBD
cord-015021-pol2qm74	8334	10	isolated	isolate	VBN
cord-015021-pol2qm74	8334	11	in	in	IN
cord-015021-pol2qm74	8334	12	22.8	22.8	CD
cord-015021-pol2qm74	8334	13	%	%	NN
cord-015021-pol2qm74	8334	14	.	.	.
cord-015021-pol2qm74	8335	1	There	there	EX
cord-015021-pol2qm74	8335	2	were	be	VBD
cord-015021-pol2qm74	8335	3	aerobic	aerobic	JJ
cord-015021-pol2qm74	8335	4	and	and	CC
cord-015021-pol2qm74	8335	5	anaerobic	anaerobic	JJ
cord-015021-pol2qm74	8335	6	associations	association	NNS
cord-015021-pol2qm74	8335	7	in	in	IN
cord-015021-pol2qm74	8335	8	12.1	12.1	CD
cord-015021-pol2qm74	8335	9	%	%	NN
cord-015021-pol2qm74	8335	10	and	and	CC
cord-015021-pol2qm74	8335	11	microflora	microflora	NN
cord-015021-pol2qm74	8335	12	was	be	VBD
cord-015021-pol2qm74	8335	13	not	not	RB
cord-015021-pol2qm74	8335	14	found	find	VBN
cord-015021-pol2qm74	8335	15	in	in	IN
cord-015021-pol2qm74	8335	16	11.6	11.6	CD
cord-015021-pol2qm74	8335	17	%	%	NN
cord-015021-pol2qm74	8335	18	of	of	IN
cord-015021-pol2qm74	8335	19	the	the	DT
cord-015021-pol2qm74	8335	20	cases	case	NNS
cord-015021-pol2qm74	8335	21	.	.	.
cord-015021-pol2qm74	8336	1	Express	express	JJ
cord-015021-pol2qm74	8336	2	method	method	NN
cord-015021-pol2qm74	8336	3	of	of	IN
cord-015021-pol2qm74	8336	4	anaerobes	anaerobe	NNS
cord-015021-pol2qm74	8336	5	discovering	discover	VBG
cord-015021-pol2qm74	8336	6	let	let	VBD
cord-015021-pol2qm74	8336	7	to	to	TO
cord-015021-pol2qm74	8336	8	receive	receive	VB
cord-015021-pol2qm74	8336	9	information	information	NN
cord-015021-pol2qm74	8336	10	on	on	IN
cord-015021-pol2qm74	8336	11	1	1	CD
cord-015021-pol2qm74	8336	12	-3	-3	NNP
cord-015021-pol2qm74	8336	13	days	day	NNS
cord-015021-pol2qm74	8336	14	early	early	RB
cord-015021-pol2qm74	8336	15	than	than	IN
cord-015021-pol2qm74	8336	16	in	in	IN
cord-015021-pol2qm74	8336	17	generally	generally	RB
cord-015021-pol2qm74	8336	18	accepted	accept	VBN
cord-015021-pol2qm74	8336	19	nethods	nethods	NNP
cord-015021-pol2qm74	8336	20	.	.	.
cord-015021-pol2qm74	8337	1	Intraaotal	Intraaotal	NNP
cord-015021-pol2qm74	8337	2	transfusion	transfusion	NN
cord-015021-pol2qm74	8337	3	of	of	IN
cord-015021-pol2qm74	8337	4	oxygenate	oxygenate	JJ
cord-015021-pol2qm74	8337	5	blood	blood	NN
cord-015021-pol2qm74	8337	6	and	and	CC
cord-015021-pol2qm74	8337	7	laser	laser	NN
cord-015021-pol2qm74	8337	8	irradiation	irradiation	NN
cord-015021-pol2qm74	8337	9	of	of	IN
cord-015021-pol2qm74	8337	10	blood	blood	NN
cord-015021-pol2qm74	8337	11	reduces	reduce	VBZ
cord-015021-pol2qm74	8337	12	the	the	DT
cord-015021-pol2qm74	8337	13	duration	duration	NN
cord-015021-pol2qm74	8337	14	of	of	IN
cord-015021-pol2qm74	8337	15	anaerobic	anaerobic	JJ
cord-015021-pol2qm74	8337	16	sow	sow	NN
cord-015021-pol2qm74	8337	17	,	,	,
cord-015021-pol2qm74	8337	18	disminishes	disminishe	NNS
cord-015021-pol2qm74	8337	19	intoxication	intoxication	NN
cord-015021-pol2qm74	8337	20	and	and	CC
cord-015021-pol2qm74	8337	21	accelerate	accelerate	VB
cord-015021-pol2qm74	8337	22	the	the	DT
cord-015021-pol2qm74	8337	23	patients	patient	NNS
cord-015021-pol2qm74	8337	24	recovery	recovery	NN
cord-015021-pol2qm74	8337	25	.	.	.
cord-015021-pol2qm74	8338	1	Patients	patient	NNS
cord-015021-pol2qm74	8338	2	with	with	IN
cord-015021-pol2qm74	8338	3	abdominal	abdominal	JJ
cord-015021-pol2qm74	8338	4	sepsis	sepsis	NN
cord-015021-pol2qm74	8338	5	are	be	VBP
cord-015021-pol2qm74	8338	6	subject	subject	JJ
cord-015021-pol2qm74	8338	7	to	to	IN
cord-015021-pol2qm74	8338	8	long	long	JJ
cord-015021-pol2qm74	8338	9	periods	period	NNS
cord-015021-pol2qm74	8338	10	of	of	IN
cord-015021-pol2qm74	8338	11	hospitalization	hospitalization	NN
cord-015021-pol2qm74	8338	12	and	and	CC
cord-015021-pol2qm74	8338	13	high	high	JJ
cord-015021-pol2qm74	8338	14	associated	associate	VBN
cord-015021-pol2qm74	8338	15	morbidity	morbidity	NN
cord-015021-pol2qm74	8338	16	and	and	CC
cord-015021-pol2qm74	8338	17	mortality	mortality	NN
cord-015021-pol2qm74	8338	18	rates	rate	NNS
cord-015021-pol2qm74	8338	19	.	.	.
cord-015021-pol2qm74	8339	1	This	this	DT
cord-015021-pol2qm74	8339	2	category	category	NN
cord-015021-pol2qm74	8339	3	of	of	IN
cord-015021-pol2qm74	8339	4	patients	patient	NNS
cord-015021-pol2qm74	8339	5	is	be	VBZ
cord-015021-pol2qm74	8339	6	thus	thus	RB
cord-015021-pol2qm74	8339	7	consuming	consume	VBG
cord-015021-pol2qm74	8339	8	extensive	extensive	JJ
cord-015021-pol2qm74	8339	9	facilities	facility	NNS
cord-015021-pol2qm74	8339	10	and	and	CC
cord-015021-pol2qm74	8339	11	costs	cost	NNS
cord-015021-pol2qm74	8339	12	.	.	.
cord-015021-pol2qm74	8340	1	As	as	IN
cord-015021-pol2qm74	8340	2	the	the	DT
cord-015021-pol2qm74	8340	3	age	age	NN
cord-015021-pol2qm74	8340	4	-	-	HYPH
cord-015021-pol2qm74	8340	5	related	relate	VBN
cord-015021-pol2qm74	8340	6	outcome	outcome	NN
cord-015021-pol2qm74	8340	7	of	of	IN
cord-015021-pol2qm74	8340	8	abdominal	abdominal	JJ
cord-015021-pol2qm74	8340	9	sepsis	sepsis	NN
cord-015021-pol2qm74	8340	10	is	be	VBZ
cord-015021-pol2qm74	8340	11	not	not	RB
cord-015021-pol2qm74	8340	12	fully	fully	RB
cord-015021-pol2qm74	8340	13	known	know	VBN
cord-015021-pol2qm74	8340	14	,	,	,
cord-015021-pol2qm74	8340	15	the	the	DT
cord-015021-pol2qm74	8340	16	aim	aim	NN
cord-015021-pol2qm74	8340	17	of	of	IN
cord-015021-pol2qm74	8340	18	the	the	DT
cord-015021-pol2qm74	8340	19	present	present	JJ
cord-015021-pol2qm74	8340	20	study	study	NN
cord-015021-pol2qm74	8340	21	was	be	VBD
cord-015021-pol2qm74	8340	22	to	to	TO
cord-015021-pol2qm74	8340	23	investigate	investigate	VB
cord-015021-pol2qm74	8340	24	abdominal	abdominal	JJ
cord-015021-pol2qm74	8340	25	sepsis	sepsis	NN
cord-015021-pol2qm74	8340	26	in	in	IN
cord-015021-pol2qm74	8340	27	the	the	DT
cord-015021-pol2qm74	8340	28	elderly	elderly	JJ
cord-015021-pol2qm74	8340	29	.	.	.
cord-015021-pol2qm74	8341	1	Out	out	IN
cord-015021-pol2qm74	8341	2	of	of	IN
cord-015021-pol2qm74	8341	3	166	166	CD
cord-015021-pol2qm74	8341	4	patients	patient	NNS
cord-015021-pol2qm74	8341	5	with	with	IN
cord-015021-pol2qm74	8341	6	abdominal	abdominal	JJ
cord-015021-pol2qm74	8341	7	sepsis	sepsis	NN
cord-015021-pol2qm74	8341	8	treated	treat	VBN
cord-015021-pol2qm74	8341	9	at	at	IN
cord-015021-pol2qm74	8341	10	the	the	DT
cord-015021-pol2qm74	8341	11	surgical	surgical	JJ
cord-015021-pol2qm74	8341	12	intensive	intensive	JJ
cord-015021-pol2qm74	8341	13	care	care	NN
cord-015021-pol2qm74	8341	14	unit	unit	NN
cord-015021-pol2qm74	8341	15	during	during	IN
cord-015021-pol2qm74	8341	16	a	a	DT
cord-015021-pol2qm74	8341	17	10-year	10-year	CD
cord-015021-pol2qm74	8341	18	period	period	NN
cord-015021-pol2qm74	8341	19	,	,	,
cord-015021-pol2qm74	8341	20	72	72	CD
cord-015021-pol2qm74	8341	21	(	(	-LRB-
cord-015021-pol2qm74	8341	22	43	43	CD
cord-015021-pol2qm74	8341	23	%	%	NN
cord-015021-pol2qm74	8341	24	)	)	-RRB-
cord-015021-pol2qm74	8341	25	had	have	VBD
cord-015021-pol2qm74	8341	26	an	an	DT
cord-015021-pol2qm74	8341	27	age	age	NN
cord-015021-pol2qm74	8341	28	of	of	IN
cord-015021-pol2qm74	8341	29	70	70	CD
cord-015021-pol2qm74	8341	30	years	year	NNS
cord-015021-pol2qm74	8341	31	or	or	CC
cord-015021-pol2qm74	8341	32	more	more	JJR
cord-015021-pol2qm74	8341	33	.	.	.
cord-015021-pol2qm74	8342	1	28	28	CD
cord-015021-pol2qm74	8342	2	were	be	VBD
cord-015021-pol2qm74	8343	1	women	woman	NNS
cord-015021-pol2qm74	8343	2	and	and	CC
cord-015021-pol2qm74	8343	3	44	44	CD
cord-015021-pol2qm74	8343	4	were	be	VBD
cord-015021-pol2qm74	8343	5	men	man	NNS
cord-015021-pol2qm74	8343	6	,	,	,
cord-015021-pol2qm74	8343	7	a	a	DT
cord-015021-pol2qm74	8343	8	sex	sex	NN
cord-015021-pol2qm74	8343	9	distribution	distribution	NN
cord-015021-pol2qm74	8343	10	not	not	RB
cord-015021-pol2qm74	8343	11	differing	differ	VBG
cord-015021-pol2qm74	8343	12	with	with	IN
cord-015021-pol2qm74	8343	13	patients	patient	NNS
cord-015021-pol2qm74	8343	14	younger	young	JJR
cord-015021-pol2qm74	8343	15	than	than	IN
cord-015021-pol2qm74	8343	16	70	70	CD
cord-015021-pol2qm74	8343	17	years	year	NNS
cord-015021-pol2qm74	8343	18	.	.	.
cord-015021-pol2qm74	8344	1	The	the	DT
cord-015021-pol2qm74	8344	2	patients	patient	NNS
cord-015021-pol2qm74	8344	3	were	be	VBD
cord-015021-pol2qm74	8344	4	scored	score	VBN
cord-015021-pol2qm74	8344	5	according	accord	VBG
cord-015021-pol2qm74	8344	6	to	to	IN
cord-015021-pol2qm74	8344	7	APACHE	APACHE	NNP
cord-015021-pol2qm74	8344	8	II	II	NNP
cord-015021-pol2qm74	8344	9	and	and	CC
cord-015021-pol2qm74	8344	10	septic	septic	JJ
cord-015021-pol2qm74	8344	11	severity	severity	NN
cord-015021-pol2qm74	8344	12	score	score	NN
cord-015021-pol2qm74	8344	13	(	(	-LRB-
cord-015021-pol2qm74	8344	14	SSS	SSS	NNP
cord-015021-pol2qm74	8344	15	)	)	-RRB-
cord-015021-pol2qm74	8344	16	upon	upon	IN
cord-015021-pol2qm74	8344	17	arrival	arrival	NN
cord-015021-pol2qm74	8344	18	to	to	IN
cord-015021-pol2qm74	8344	19	the	the	DT
cord-015021-pol2qm74	8344	20	intensive	intensive	JJ
cord-015021-pol2qm74	8344	21	care	care	NN
cord-015021-pol2qm74	8344	22	unit	unit	NN
cord-015021-pol2qm74	8344	23	.	.	.
cord-015021-pol2qm74	8345	1	Bacterial	bacterial	JJ
cord-015021-pol2qm74	8345	2	cultures	culture	NNS
cord-015021-pol2qm74	8345	3	,	,	,
cord-015021-pol2qm74	8345	4	the	the	DT
cord-015021-pol2qm74	8345	5	occurrence	occurrence	NN
cord-015021-pol2qm74	8345	6	of	of	IN
cord-015021-pol2qm74	8345	7	organ	organ	NN
cord-015021-pol2qm74	8345	8	failure	failure	NN
cord-015021-pol2qm74	8345	9	,	,	,
cord-015021-pol2qm74	8345	10	hospitalization	hospitalization	NN
cord-015021-pol2qm74	8345	11	and	and	CC
cord-015021-pol2qm74	8345	12	outcome	outcome	NN
cord-015021-pol2qm74	8345	13	was	be	VBD
cord-015021-pol2qm74	8345	14	noted	note	VBN
cord-015021-pol2qm74	8345	15	.	.	.
cord-015021-pol2qm74	8346	1	In	in	IN
cord-015021-pol2qm74	8346	2	median	median	JJ
cord-015021-pol2qm74	8346	3	two	two	CD
cord-015021-pol2qm74	8346	4	operations	operation	NNS
cord-015021-pol2qm74	8346	5	were	be	VBD
cord-015021-pol2qm74	8346	6	performed	perform	VBN
cord-015021-pol2qm74	8346	7	for	for	IN
cord-015021-pol2qm74	8346	8	both	both	DT
cord-015021-pol2qm74	8346	9	"	"	``
cord-015021-pol2qm74	8346	10	younger	young	JJR
cord-015021-pol2qm74	8346	11	and	and	CC
cord-015021-pol2qm74	8346	12	elderly	elderly	JJ
cord-015021-pol2qm74	8346	13	"	"	''
cord-015021-pol2qm74	8346	14	patients	patient	NNS
cord-015021-pol2qm74	8346	15	.	.	.
cord-015021-pol2qm74	8347	1	The	the	DT
cord-015021-pol2qm74	8347	2	median	median	JJ
cord-015021-pol2qm74	8347	3	time	time	NN
cord-015021-pol2qm74	8347	4	of	of	IN
cord-015021-pol2qm74	8347	5	hospitalization	hospitalization	NN
cord-015021-pol2qm74	8347	6	in	in	IN
cord-015021-pol2qm74	8347	7	the	the	DT
cord-015021-pol2qm74	8347	8	elderly	elderly	JJ
cord-015021-pol2qm74	8347	9	was	be	VBD
cord-015021-pol2qm74	8347	10	29	29	CD
cord-015021-pol2qm74	8347	11	(	(	-LRB-
cord-015021-pol2qm74	8347	12	-183	-183	NNP
cord-015021-pol2qm74	8347	13	)	)	-RRB-
cord-015021-pol2qm74	8347	14	days	day	NNS
cord-015021-pol2qm74	8347	15	including	include	VBG
cord-015021-pol2qm74	8347	16	in	in	IN
cord-015021-pol2qm74	8347	17	median	median	JJ
cord-015021-pol2qm74	8347	18	10	10	CD
cord-015021-pol2qm74	8347	19	days	day	NNS
cord-015021-pol2qm74	8347	20	in	in	IN
cord-015021-pol2qm74	8347	21	the	the	DT
cord-015021-pol2qm74	8347	22	ICU	ICU	NNP
cord-015021-pol2qm74	8347	23	.	.	.
cord-015021-pol2qm74	8348	1	Figures	figure	NNS
cord-015021-pol2qm74	8348	2	in	in	IN
cord-015021-pol2qm74	8348	3	patients	patient	NNS
cord-015021-pol2qm74	8348	4	less	less	JJR
cord-015021-pol2qm74	8348	5	than	than	IN
cord-015021-pol2qm74	8348	6	70	70	CD
cord-015021-pol2qm74	8348	7	years	year	NNS
cord-015021-pol2qm74	8348	8	of	of	IN
cord-015021-pol2qm74	8348	9	age	age	NN
cord-015021-pol2qm74	8348	10	were	be	VBD
cord-015021-pol2qm74	8348	11	comparable	comparable	JJ
cord-015021-pol2qm74	8348	12	(	(	-LRB-
cord-015021-pol2qm74	8348	13	34	34	CD
cord-015021-pol2qm74	8348	14	(	(	-LRB-
cord-015021-pol2qm74	8348	15	-293	-293	NNP
cord-015021-pol2qm74	8348	16	)	)	-RRB-
cord-015021-pol2qm74	8348	17	days	day	NNS
cord-015021-pol2qm74	8348	18	out	out	IN
cord-015021-pol2qm74	8348	19	of	of	IN
cord-015021-pol2qm74	8348	20	which	which	WDT
cord-015021-pol2qm74	8348	21	in	in	IN
cord-015021-pol2qm74	8348	22	median	median	JJ
cord-015021-pol2qm74	8348	23	10	10	CD
cord-015021-pol2qm74	8348	24	days	day	NNS
cord-015021-pol2qm74	8348	25	in	in	IN
cord-015021-pol2qm74	8348	26	the	the	DT
cord-015021-pol2qm74	8348	27	ICU	ICU	NNP
cord-015021-pol2qm74	8348	28	)	)	-RRB-
cord-015021-pol2qm74	8348	29	.	.	.
cord-015021-pol2qm74	8349	1	APACHE	APACHE	NNP
cord-015021-pol2qm74	8349	2	II	II	NNP
cord-015021-pol2qm74	8349	3	and	and	CC
cord-015021-pol2qm74	8349	4	SSS	SSS	NNP
cord-015021-pol2qm74	8349	5	-	-	HYPH
cord-015021-pol2qm74	8349	6	scores	score	NNS
cord-015021-pol2qm74	8349	7	did	do	VBD
cord-015021-pol2qm74	8349	8	not	not	RB
cord-015021-pol2qm74	8349	9	significantly	significantly	RB
cord-015021-pol2qm74	8349	10	differ	differ	VB
cord-015021-pol2qm74	8349	11	(	(	-LRB-
cord-015021-pol2qm74	8349	12	14.2	14.2	CD
cord-015021-pol2qm74	8349	13	vs	vs	IN
cord-015021-pol2qm74	8349	14	13	13	CD
cord-015021-pol2qm74	8349	15	and	and	CC
cord-015021-pol2qm74	8349	16	23.3	23.3	CD
cord-015021-pol2qm74	8349	17	vs	vs	IN
cord-015021-pol2qm74	8349	18	26.5	26.5	CD
cord-015021-pol2qm74	8349	19	,	,	,
cord-015021-pol2qm74	8349	20	respectively	respectively	RB
cord-015021-pol2qm74	8349	21	)	)	-RRB-
cord-015021-pol2qm74	8349	22	,	,	,
cord-015021-pol2qm74	8349	23	between	between	IN
cord-015021-pol2qm74	8349	24	the	the	DT
cord-015021-pol2qm74	8349	25	groups	group	NNS
cord-015021-pol2qm74	8349	26	.	.	.
cord-015021-pol2qm74	8350	1	Neither	neither	DT
cord-015021-pol2qm74	8350	2	did	do	VBD
cord-015021-pol2qm74	8350	3	the	the	DT
cord-015021-pol2qm74	8350	4	incidence	incidence	NN
cord-015021-pol2qm74	8350	5	of	of	IN
cord-015021-pol2qm74	8350	6	organ	organ	NN
cord-015021-pol2qm74	8350	7	failure	failure	NN
cord-015021-pol2qm74	8350	8	differ	differ	VBP
cord-015021-pol2qm74	8350	9	(	(	-LRB-
cord-015021-pol2qm74	8350	10	57/73	57/73	CD
cord-015021-pol2qm74	8350	11	vs	vs	IN
cord-015021-pol2qm74	8350	12	77/94	77/94	CD
cord-015021-pol2qm74	8350	13	)	)	-RRB-
cord-015021-pol2qm74	8350	14	.	.	.
cord-015021-pol2qm74	8351	1	However	however	RB
cord-015021-pol2qm74	8351	2	,	,	,
cord-015021-pol2qm74	8351	3	the	the	DT
cord-015021-pol2qm74	8351	4	incidence	incidence	NN
cord-015021-pol2qm74	8351	5	of	of	IN
cord-015021-pol2qm74	8351	6	multiple	multiple	JJ
cord-015021-pol2qm74	8351	7	organ	organ	NN
cord-015021-pol2qm74	8351	8	failure	failure	NN
cord-015021-pol2qm74	8351	9	was	be	VBD
cord-015021-pol2qm74	8351	10	significantly	significantly	RB
cord-015021-pol2qm74	8351	11	lower	low	JJR
cord-015021-pol2qm74	8351	12	in	in	IN
cord-015021-pol2qm74	8351	13	elderly	elderly	JJ
cord-015021-pol2qm74	8351	14	patients	patient	NNS
cord-015021-pol2qm74	8351	15	(	(	-LRB-
cord-015021-pol2qm74	8351	16	21/72	21/72	CD
cord-015021-pol2qm74	8351	17	vs	vs	IN
cord-015021-pol2qm74	8351	18	42/94	42/94	CD
cord-015021-pol2qm74	8351	19	(	(	-LRB-
cord-015021-pol2qm74	8351	20	p	p	NN
cord-015021-pol2qm74	8351	21	<	<	XX
cord-015021-pol2qm74	8351	22	0.001	0.001	CD
cord-015021-pol2qm74	8351	23	)	)	-RRB-
cord-015021-pol2qm74	8351	24	)	)	-RRB-
cord-015021-pol2qm74	8351	25	.	.	.
cord-015021-pol2qm74	8352	1	The	the	DT
cord-015021-pol2qm74	8352	2	mortality	mortality	NN
cord-015021-pol2qm74	8352	3	rate	rate	NN
cord-015021-pol2qm74	8352	4	,	,	,
cord-015021-pol2qm74	8352	5	however	however	RB
cord-015021-pol2qm74	8352	6	,	,	,
cord-015021-pol2qm74	8352	7	did	do	VBD
cord-015021-pol2qm74	8352	8	not	not	RB
cord-015021-pol2qm74	8352	9	differ	differ	VB
cord-015021-pol2qm74	8352	10	between	between	IN
cord-015021-pol2qm74	8352	11	the	the	DT
cord-015021-pol2qm74	8352	12	groups	group	NNS
cord-015021-pol2qm74	8352	13	(	(	-LRB-
cord-015021-pol2qm74	8352	14	21/72	21/72	CD
cord-015021-pol2qm74	8352	15	vs	vs	IN
cord-015021-pol2qm74	8352	16	26/94	26/94	CD
cord-015021-pol2qm74	8352	17	)	)	-RRB-
cord-015021-pol2qm74	8352	18	.	.	.
cord-015021-pol2qm74	8353	1	In	in	IN
cord-015021-pol2qm74	8353	2	conclusion	conclusion	NN
cord-015021-pol2qm74	8353	3	,	,	,
cord-015021-pol2qm74	8353	4	severe	severe	JJ
cord-015021-pol2qm74	8353	5	abdominal	abdominal	JJ
cord-015021-pol2qm74	8353	6	sepsis	sepsis	NN
cord-015021-pol2qm74	8353	7	in	in	IN
cord-015021-pol2qm74	8353	8	the	the	DT
cord-015021-pol2qm74	8353	9	elderly	elderly	JJ
cord-015021-pol2qm74	8353	10	was	be	VBD
cord-015021-pol2qm74	8353	11	not	not	RB
cord-015021-pol2qm74	8353	12	associated	associate	VBN
cord-015021-pol2qm74	8353	13	with	with	IN
cord-015021-pol2qm74	8353	14	an	an	DT
cord-015021-pol2qm74	8353	15	increase	increase	NN
cord-015021-pol2qm74	8353	16	in	in	IN
cord-015021-pol2qm74	8353	17	mortality	mortality	NN
cord-015021-pol2qm74	8353	18	,	,	,
cord-015021-pol2qm74	8353	19	incidence	incidence	NN
cord-015021-pol2qm74	8353	20	of	of	IN
cord-015021-pol2qm74	8353	21	organ	organ	NN
cord-015021-pol2qm74	8353	22	failure	failure	NN
cord-015021-pol2qm74	8353	23	or	or	CC
cord-015021-pol2qm74	8353	24	hospital	hospital	NN
cord-015021-pol2qm74	8353	25	stay	stay	NN
cord-015021-pol2qm74	8353	26	.	.	.
cord-015021-pol2qm74	8354	1	With	with	IN
cord-015021-pol2qm74	8354	2	the	the	DT
cord-015021-pol2qm74	8354	3	help	help	NN
cord-015021-pol2qm74	8354	4	of	of	IN
cord-015021-pol2qm74	8354	5	light	light	JJ
cord-015021-pol2qm74	8354	6	transmissional	transmissional	JJ
cord-015021-pol2qm74	8354	7	scanning	scanning	NN
cord-015021-pol2qm74	8354	8	electron	electron	NN
cord-015021-pol2qm74	8354	9	microscopy	microscopy	NN
cord-015021-pol2qm74	8354	10	morphology	morphology	NN
cord-015021-pol2qm74	8354	11	of	of	IN
cord-015021-pol2qm74	8354	12	erythrosytes	erythrosyte	NNS
cord-015021-pol2qm74	8354	13	of	of	IN
cord-015021-pol2qm74	8354	14	peripheric	peripheric	JJ
cord-015021-pol2qm74	8354	15	blood	blood	NN
cord-015021-pol2qm74	8354	16	was	be	VBD
cord-015021-pol2qm74	8354	17	studied	study	VBN
cord-015021-pol2qm74	8354	18	in	in	IN
cord-015021-pol2qm74	8354	19	patients	patient	NNS
cord-015021-pol2qm74	8354	20	with	with	IN
cord-015021-pol2qm74	8354	21	different	different	JJ
cord-015021-pol2qm74	8354	22	stages	stage	NNS
cord-015021-pol2qm74	8354	23	of	of	IN
cord-015021-pol2qm74	8354	24	diffuse	diffuse	JJ
cord-015021-pol2qm74	8354	25	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8354	26	before	before	IN
cord-015021-pol2qm74	8354	27	and	and	CC
cord-015021-pol2qm74	8354	28	after	after	IN
cord-015021-pol2qm74	8354	29	intravascu!ar	intravascu!ar	JJ
cord-015021-pol2qm74	8354	30	irradiation	irradiation	NN
cord-015021-pol2qm74	8354	31	of	of	IN
cord-015021-pol2qm74	8354	32	blood	blood	NN
cord-015021-pol2qm74	8354	33	with	with	IN
cord-015021-pol2qm74	8354	34	heliun	heliun	JJ
cord-015021-pol2qm74	8354	35	-	-	HYPH
cord-015021-pol2qm74	8354	36	neon	neon	NN
cord-015021-pol2qm74	8354	37	laser	laser	NN
cord-015021-pol2qm74	8354	38	.	.	.
cord-015021-pol2qm74	8355	1	Peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8355	2	morphology	morphology	NN
cord-015021-pol2qm74	8355	3	was	be	VBD
cord-015021-pol2qm74	8355	4	investigated	investigate	VBN
cord-015021-pol2qm74	8355	5	in	in	IN
cord-015021-pol2qm74	8355	6	patients	patient	NNS
cord-015021-pol2qm74	8355	7	who	who	WP
cord-015021-pol2qm74	8355	8	died	die	VBD
cord-015021-pol2qm74	8355	9	from	from	IN
cord-015021-pol2qm74	8355	10	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8355	11	,	,	,
cord-015021-pol2qm74	8355	12	It	-PRON-	PRP
cord-015021-pol2qm74	8355	13	was	be	VBD
cord-015021-pol2qm74	8355	14	established	establish	VBN
cord-015021-pol2qm74	8355	15	that	that	IN
cord-015021-pol2qm74	8355	16	in	in	IN
cord-015021-pol2qm74	8355	17	all	all	DT
cord-015021-pol2qm74	8355	18	phases	phase	NNS
cord-015021-pol2qm74	8355	19	of	of	IN
cord-015021-pol2qm74	8355	20	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8355	21	occured	occur	VBD
cord-015021-pol2qm74	8355	22	stomatocytoric	stomatocytoric	NNP
cord-015021-pol2qm74	8355	23	and	and	CC
cord-015021-pol2qm74	8355	24	echinocytoric	echinocytoric	JJ
cord-015021-pol2qm74	8355	25	transformation	transformation	NN
cord-015021-pol2qm74	8355	26	of	of	IN
cord-015021-pol2qm74	8355	27	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	8355	28	which	which	WDT
cord-015021-pol2qm74	8355	29	progressed	progress	VBD
cord-015021-pol2qm74	8355	30	simultaneously	simultaneously	RB
cord-015021-pol2qm74	8355	31	with	with	IN
cord-015021-pol2qm74	8355	32	increase	increase	NN
cord-015021-pol2qm74	8355	33	of	of	IN
cord-015021-pol2qm74	8355	34	intoxication	intoxication	NN
cord-015021-pol2qm74	8355	35	.	.	.
cord-015021-pol2qm74	8356	1	It	-PRON-	PRP
cord-015021-pol2qm74	8356	2	combined	combine	VBD
cord-015021-pol2qm74	8356	3	with	with	IN
cord-015021-pol2qm74	8356	4	strongly	strongly	RB
cord-015021-pol2qm74	8356	5	pronounced	pronounce	VBN
cord-015021-pol2qm74	8356	6	vessels	vessel	NNS
cord-015021-pol2qm74	8356	7	variability	variability	NN
cord-015021-pol2qm74	8356	8	of	of	IN
cord-015021-pol2qm74	8356	9	microcirculatory	microcirculatory	NNP
cord-015021-pol2qm74	8356	10	peritoneal	peritoneal	NNP
cord-015021-pol2qm74	8356	11	bed	bed	NNP
cord-015021-pol2qm74	8356	12	which	which	WDT
cord-015021-pol2qm74	8356	13	displaied	displaie	VBN
cord-015021-pol2qm74	8356	14	by	by	IN
cord-015021-pol2qm74	8356	15	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	8356	16	aggregation	aggregation	NN
cord-015021-pol2qm74	8356	17	,	,	,
cord-015021-pol2qm74	8356	18	stasis	stasis	NN
cord-015021-pol2qm74	8356	19	and	and	CC
cord-015021-pol2qm74	8356	20	microtrombogenesis	microtrombogenesis	NN
cord-015021-pol2qm74	8356	21	.	.	.
cord-015021-pol2qm74	8357	1	In	in	IN
cord-015021-pol2qm74	8357	2	intravascular	intravascular	JJ
cord-015021-pol2qm74	8357	3	laser	laser	NN
cord-015021-pol2qm74	8357	4	irradiation	irradiation	NN
cord-015021-pol2qm74	8357	5	of	of	IN
cord-015021-pol2qm74	8357	6	blood	blood	NN
cord-015021-pol2qm74	8357	7	number	number	NN
cord-015021-pol2qm74	8357	8	of	of	IN
cord-015021-pol2qm74	8357	9	erythrocytes	erythrocyte	NNS
cord-015021-pol2qm74	8357	10	which	which	WDT
cord-015021-pol2qm74	8357	11	underwent	undergo	VBD
cord-015021-pol2qm74	8357	12	to	to	IN
cord-015021-pol2qm74	8357	13	stomatocytoric	stomatocytoric	NNP
cord-015021-pol2qm74	8357	14	and	and	CC
cord-015021-pol2qm74	8357	15	echinooytorie	echinooytorie	NNP
cord-015021-pol2qm74	8357	16	transformation	transformation	NN
cord-015021-pol2qm74	8357	17	was	be	VBD
cord-015021-pol2qm74	8357	18	lower	low	JJR
cord-015021-pol2qm74	8357	19	than	than	IN
cord-015021-pol2qm74	8357	20	in	in	IN
cord-015021-pol2qm74	8357	21	patients	patient	NNS
cord-015021-pol2qm74	8357	22	without	without	IN
cord-015021-pol2qm74	8357	23	laser	laser	NN
cord-015021-pol2qm74	8357	24	irradiation	irradiation	NN
cord-015021-pol2qm74	8357	25	.	.	.
cord-015021-pol2qm74	8358	1	It	-PRON-	PRP
cord-015021-pol2qm74	8358	2	indicated	indicate	VBD
cord-015021-pol2qm74	8358	3	that	that	IN
cord-015021-pol2qm74	8358	4	the	the	DT
cord-015021-pol2qm74	8358	5	intravascular	intravascular	JJ
cord-015021-pol2qm74	8358	6	irradiation	irradiation	NN
cord-015021-pol2qm74	8358	7	of	of	IN
cord-015021-pol2qm74	8358	8	blood	blood	NN
cord-015021-pol2qm74	8358	9	with	with	IN
cord-015021-pol2qm74	8358	10	helium	helium	NN
cord-015021-pol2qm74	8358	11	-	-	HYPH
cord-015021-pol2qm74	8358	12	neon	neon	NN
cord-015021-pol2qm74	8358	13	laser	laser	NN
cord-015021-pol2qm74	8358	14	can	can	MD
cord-015021-pol2qm74	8358	15	prevent	prevent	VB
cord-015021-pol2qm74	8358	16	development	development	NN
cord-015021-pol2qm74	8358	17	of	of	IN
cord-015021-pol2qm74	8358	18	severe	severe	JJ
cord-015021-pol2qm74	8358	19	alterations	alteration	NNS
cord-015021-pol2qm74	8358	20	of	of	IN
cord-015021-pol2qm74	8358	21	rheological	rheological	JJ
cord-015021-pol2qm74	8358	22	property	property	NN
cord-015021-pol2qm74	8358	23	of	of	IN
cord-015021-pol2qm74	8358	24	blood	blood	NN
cord-015021-pol2qm74	8358	25	and	and	CC
cord-015021-pol2qm74	8358	26	consequently	consequently	RB
cord-015021-pol2qm74	8358	27	variability	variability	NN
cord-015021-pol2qm74	8358	28	of	of	IN
cord-015021-pol2qm74	8358	29	microcirlatory	microcirlatory	NNP
cord-015021-pol2qm74	8358	30	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8358	31	bed	bed	NN
cord-015021-pol2qm74	8358	32	in	in	IN
cord-015021-pol2qm74	8358	33	patients	patient	NNS
cord-015021-pol2qm74	8358	34	with	with	IN
cord-015021-pol2qm74	8358	35	diffuse	diffuse	JJ
cord-015021-pol2qm74	8358	36	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8358	37	.	.	.
cord-015021-pol2qm74	8359	1	Abdominal	abdominal	JJ
cord-015021-pol2qm74	8359	2	sepsis	sepsis	NN
cord-015021-pol2qm74	8359	3	is	be	VBZ
cord-015021-pol2qm74	8359	4	still	still	RB
cord-015021-pol2qm74	8359	5	associated	associate	VBN
cord-015021-pol2qm74	8359	6	with	with	IN
cord-015021-pol2qm74	8359	7	high	high	JJ
cord-015021-pol2qm74	8359	8	morbidity	morbidity	NN
cord-015021-pol2qm74	8359	9	and	and	CC
cord-015021-pol2qm74	8359	10	mortality	mortality	NN
cord-015021-pol2qm74	8359	11	rates	rate	NNS
cord-015021-pol2qm74	8359	12	,	,	,
cord-015021-pol2qm74	8359	13	frequenfly	frequenfly	NN
cord-015021-pol2qm74	8359	14	caused	cause	VBN
cord-015021-pol2qm74	8359	15	by	by	IN
cord-015021-pol2qm74	8359	16	multiple	multiple	JJ
cord-015021-pol2qm74	8359	17	organ	organ	NN
cord-015021-pol2qm74	8359	18	failure	failure	NN
cord-015021-pol2qm74	8359	19	.	.	.
cord-015021-pol2qm74	8360	1	It	-PRON-	PRP
cord-015021-pol2qm74	8360	2	has	have	VBZ
cord-015021-pol2qm74	8360	3	been	be	VBN
cord-015021-pol2qm74	8360	4	reported	report	VBN
cord-015021-pol2qm74	8360	5	that	that	IN
cord-015021-pol2qm74	8360	6	changes	change	NNS
cord-015021-pol2qm74	8360	7	in	in	IN
cord-015021-pol2qm74	8360	8	capillary	capillary	JJ
cord-015021-pol2qm74	8360	9	permeability	permeability	NN
cord-015021-pol2qm74	8360	10	play	play	VBP
cord-015021-pol2qm74	8360	11	a	a	DT
cord-015021-pol2qm74	8360	12	role	role	NN
cord-015021-pol2qm74	8360	13	in	in	IN
cord-015021-pol2qm74	8360	14	the	the	DT
cord-015021-pol2qm74	8360	15	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8360	16	of	of	IN
cord-015021-pol2qm74	8360	17	multiple	multiple	JJ
cord-015021-pol2qm74	8360	18	organ	organ	NN
cord-015021-pol2qm74	8360	19	failure	failure	NN
cord-015021-pol2qm74	8360	20	.	.	.
cord-015021-pol2qm74	8361	1	The	the	DT
cord-015021-pol2qm74	8361	2	present	present	JJ
cord-015021-pol2qm74	8361	3	study	study	NN
cord-015021-pol2qm74	8361	4	aimed	aim	VBN
cord-015021-pol2qm74	8361	5	at	at	IN
cord-015021-pol2qm74	8361	6	evaluating	evaluate	VBG
cord-015021-pol2qm74	8361	7	the	the	DT
cord-015021-pol2qm74	8361	8	influence	influence	NN
cord-015021-pol2qm74	8361	9	of	of	IN
cord-015021-pol2qm74	8361	10	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8361	11	sepsis	sepsis	NN
cord-015021-pol2qm74	8361	12	induced	induce	VBN
cord-015021-pol2qm74	8361	13	by	by	IN
cord-015021-pol2qm74	8361	14	cekal	cekal	JJ
cord-015021-pol2qm74	8361	15	ligation	ligation	NN
cord-015021-pol2qm74	8361	16	and	and	CC
cord-015021-pol2qm74	8361	17	puncture	puncture	NN
cord-015021-pol2qm74	8361	18	on	on	IN
cord-015021-pol2qm74	8361	19	capillary	capillary	JJ
cord-015021-pol2qm74	8361	20	permeability	permeability	NN
cord-015021-pol2qm74	8361	21	in	in	IN
cord-015021-pol2qm74	8361	22	multiple	multiple	JJ
cord-015021-pol2qm74	8361	23	organs	organ	NNS
cord-015021-pol2qm74	8361	24	and	and	CC
cord-015021-pol2qm74	8361	25	tissues	tissue	NNS
cord-015021-pol2qm74	8361	26	.	.	.
cord-015021-pol2qm74	8362	1	96	96	CD
cord-015021-pol2qm74	8362	2	adult	adult	NN
cord-015021-pol2qm74	8362	3	male	male	JJ
cord-015021-pol2qm74	8362	4	Sprague	Sprague	NNP
cord-015021-pol2qm74	8362	5	-	-	HYPH
cord-015021-pol2qm74	8362	6	Dawley	Dawley	NNP
cord-015021-pol2qm74	8362	7	rats	rat	NNS
cord-015021-pol2qm74	8362	8	were	be	VBD
cord-015021-pol2qm74	8362	9	subjected	subject	VBN
cord-015021-pol2qm74	8362	10	to	to	IN
cord-015021-pol2qm74	8362	11	laparotomy	laparotomy	NN
cord-015021-pol2qm74	8362	12	with	with	IN
cord-015021-pol2qm74	8362	13	separation	separation	NN
cord-015021-pol2qm74	8362	14	of	of	IN
cord-015021-pol2qm74	8362	15	the	the	DT
cord-015021-pol2qm74	8362	16	cekum	cekum	NNP
cord-015021-pol2qm74	8362	17	(	(	-LRB-
cord-015021-pol2qm74	8362	18	sham	sham	NNP
cord-015021-pol2qm74	8362	19	operation	operation	NN
cord-015021-pol2qm74	8362	20	)	)	-RRB-
cord-015021-pol2qm74	8362	21	or	or	CC
cord-015021-pol2qm74	8362	22	induction	induction	NN
cord-015021-pol2qm74	8362	23	of	of	IN
cord-015021-pol2qm74	8362	24	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8362	25	sepsis	sepsis	NN
cord-015021-pol2qm74	8362	26	by	by	IN
cord-015021-pol2qm74	8362	27	cekal	cekal	NNP
cord-015021-pol2qm74	8362	28	ligation	ligation	NNP
cord-015021-pol2qm74	8362	29	and	and	CC
cord-015021-pol2qm74	8362	30	puneatre	puneatre	NNP
cord-015021-pol2qm74	8363	1	(	(	-LRB-
cord-015021-pol2qm74	8363	2	n--48	n--48	NNP
cord-015021-pol2qm74	8363	3	in	in	IN
cord-015021-pol2qm74	8363	4	each	each	DT
cord-015021-pol2qm74	8363	5	group	group	NN
cord-015021-pol2qm74	8363	6	)	)	-RRB-
cord-015021-pol2qm74	8363	7	.	.	.
cord-015021-pol2qm74	8364	1	At	at	IN
cord-015021-pol2qm74	8364	2	3	3	CD
cord-015021-pol2qm74	8364	3	,	,	,
cord-015021-pol2qm74	8364	4	6	6	CD
cord-015021-pol2qm74	8364	5	,	,	,
cord-015021-pol2qm74	8364	6	12	12	CD
cord-015021-pol2qm74	8364	7	,	,	,
cord-015021-pol2qm74	8364	8	24	24	CD
cord-015021-pol2qm74	8364	9	,	,	,
cord-015021-pol2qm74	8364	10	48	48	CD
cord-015021-pol2qm74	8364	11	and	and	CC
cord-015021-pol2qm74	8364	12	72	72	CD
cord-015021-pol2qm74	8364	13	hours	hour	NNS
cord-015021-pol2qm74	8364	14	(	(	-LRB-
cord-015021-pol2qm74	8364	15	n=6	n=6	NNP
cord-015021-pol2qm74	8364	16	/	/	SYM
cord-015021-pol2qm74	8364	17	timepoint	timepoint	NN
cord-015021-pol2qm74	8364	18	)	)	-RRB-
cord-015021-pol2qm74	8364	19	,	,	,
cord-015021-pol2qm74	8364	20	the	the	DT
cord-015021-pol2qm74	8364	21	animals	animal	NNS
cord-015021-pol2qm74	8364	22	were	be	VBD
cord-015021-pol2qm74	8364	23	evaluated	evaluate	VBN
cord-015021-pol2qm74	8364	24	concerning	concern	VBG
cord-015021-pol2qm74	8364	25	mortality	mortality	NN
cord-015021-pol2qm74	8364	26	and	and	CC
cord-015021-pol2qm74	8364	27	capillary	capillary	JJ
cord-015021-pol2qm74	8364	28	permeability	permeability	NN
cord-015021-pol2qm74	8364	29	as	as	IN
cord-015021-pol2qm74	8364	30	determined	determine	VBN
cord-015021-pol2qm74	8364	31	by	by	IN
cord-015021-pol2qm74	8364	32	the	the	DT
cord-015021-pol2qm74	8364	33	passage	passage	NN
cord-015021-pol2qm74	8364	34	of	of	IN
cord-015021-pol2qm74	8364	35	:	:	:
cord-015021-pol2qm74	8364	36	25I	25i	LS
cord-015021-pol2qm74	8364	37	-	-	HYPH
cord-015021-pol2qm74	8364	38	labelled	label	VBN
cord-015021-pol2qm74	8364	39	albumin	albumin	NN
cord-015021-pol2qm74	8364	40	from	from	IN
cord-015021-pol2qm74	8364	41	capillaries	capillary	NNS
cord-015021-pol2qm74	8364	42	to	to	IN
cord-015021-pol2qm74	8364	43	the	the	DT
cord-015021-pol2qm74	8364	44	peritoneum	peritoneum	NN
cord-015021-pol2qm74	8364	45	,	,	,
cord-015021-pol2qm74	8364	46	the	the	DT
cord-015021-pol2qm74	8364	47	proximal	proximal	JJ
cord-015021-pol2qm74	8364	48	and	and	CC
cord-015021-pol2qm74	8364	49	distal	distal	JJ
cord-015021-pol2qm74	8364	50	small	small	JJ
cord-015021-pol2qm74	8364	51	intestine	intestine	NN
cord-015021-pol2qm74	8364	52	,	,	,
cord-015021-pol2qm74	8364	53	cekum	cekum	NNP
cord-015021-pol2qm74	8364	54	,	,	,
cord-015021-pol2qm74	8364	55	colon	colon	NN
cord-015021-pol2qm74	8364	56	,	,	,
cord-015021-pol2qm74	8364	57	spleen	spleen	NNS
cord-015021-pol2qm74	8364	58	,	,	,
cord-015021-pol2qm74	8364	59	kidneys	kidney	NNS
cord-015021-pol2qm74	8364	60	,	,	,
cord-015021-pol2qm74	8364	61	lungs	lung	NNS
cord-015021-pol2qm74	8364	62	.	.	.
cord-015021-pol2qm74	8365	1	The	the	DT
cord-015021-pol2qm74	8365	2	mortality	mortality	NN
cord-015021-pol2qm74	8365	3	rate	rate	NN
cord-015021-pol2qm74	8365	4	in	in	IN
cord-015021-pol2qm74	8365	5	rats	rat	NNS
cord-015021-pol2qm74	8365	6	with	with	IN
cord-015021-pol2qm74	8365	7	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8365	8	sepsis	sepsis	NN
cord-015021-pol2qm74	8365	9	was	be	VBD
cord-015021-pol2qm74	8365	10	33	33	CD
cord-015021-pol2qm74	8365	11	%	%	NN
cord-015021-pol2qm74	8365	12	both	both	DT
cord-015021-pol2qm74	8365	13	at	at	IN
cord-015021-pol2qm74	8365	14	48	48	CD
cord-015021-pol2qm74	8365	15	and	and	CC
cord-015021-pol2qm74	8365	16	72	72	CD
cord-015021-pol2qm74	8365	17	hours	hour	NNS
cord-015021-pol2qm74	8365	18	.	.	.
cord-015021-pol2qm74	8366	1	Capillary	capillary	JJ
cord-015021-pol2qm74	8366	2	permeability	permeability	NN
cord-015021-pol2qm74	8366	3	in	in	IN
cord-015021-pol2qm74	8366	4	the	the	DT
cord-015021-pol2qm74	8366	5	peritoneum	peritoneum	NN
cord-015021-pol2qm74	8366	6	,	,	,
cord-015021-pol2qm74	8366	7	cekum	cekum	NNP
cord-015021-pol2qm74	8366	8	,	,	,
cord-015021-pol2qm74	8366	9	colon	colon	NN
cord-015021-pol2qm74	8366	10	and	and	CC
cord-015021-pol2qm74	8366	11	kidneys	kidney	NNS
cord-015021-pol2qm74	8366	12	significantly	significantly	RB
cord-015021-pol2qm74	8366	13	increased	increase	VBD
cord-015021-pol2qm74	8366	14	from	from	IN
cord-015021-pol2qm74	8366	15	6	6	CD
cord-015021-pol2qm74	8366	16	hours	hour	NNS
cord-015021-pol2qm74	8366	17	and	and	CC
cord-015021-pol2qm74	8366	18	on	on	RB
cord-015021-pol2qm74	8366	19	in	in	IN
cord-015021-pol2qm74	8366	20	rats	rat	NNS
cord-015021-pol2qm74	8366	21	with	with	IN
cord-015021-pol2qm74	8366	22	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8366	23	sepsis	sepsis	NN
cord-015021-pol2qm74	8366	24	.	.	.
cord-015021-pol2qm74	8367	1	In	in	IN
cord-015021-pol2qm74	8367	2	septic	septic	JJ
cord-015021-pol2qm74	8367	3	animals	animal	NNS
cord-015021-pol2qm74	8367	4	,	,	,
cord-015021-pol2qm74	8367	5	capillary	capillary	JJ
cord-015021-pol2qm74	8367	6	permeability	permeability	NN
cord-015021-pol2qm74	8367	7	in	in	IN
cord-015021-pol2qm74	8367	8	the	the	DT
cord-015021-pol2qm74	8367	9	lungs	lung	NNS
cord-015021-pol2qm74	8367	10	and	and	CC
cord-015021-pol2qm74	8367	11	spleen	spleen	NNS
cord-015021-pol2qm74	8367	12	increased	increase	VBD
cord-015021-pol2qm74	8367	13	from	from	IN
cord-015021-pol2qm74	8367	14	12	12	CD
cord-015021-pol2qm74	8367	15	hours	hour	NNS
cord-015021-pol2qm74	8367	16	and	and	CC
cord-015021-pol2qm74	8367	17	on	on	RB
cord-015021-pol2qm74	8367	18	and	and	CC
cord-015021-pol2qm74	8367	19	in	in	IN
cord-015021-pol2qm74	8367	20	the	the	DT
cord-015021-pol2qm74	8367	21	proximal	proximal	JJ
cord-015021-pol2qm74	8367	22	and	and	CC
cord-015021-pol2qm74	8367	23	distal	distal	JJ
cord-015021-pol2qm74	8367	24	small	small	JJ
cord-015021-pol2qm74	8367	25	intestine	intestine	NN
cord-015021-pol2qm74	8367	26	from	from	IN
cord-015021-pol2qm74	8367	27	24	24	CD
cord-015021-pol2qm74	8367	28	hours	hour	NNS
cord-015021-pol2qm74	8367	29	and	and	CC
cord-015021-pol2qm74	8367	30	on	on	RB
cord-015021-pol2qm74	8367	31	.	.	.
cord-015021-pol2qm74	8368	1	Different	different	JJ
cord-015021-pol2qm74	8368	2	types	type	NNS
cord-015021-pol2qm74	8368	3	of	of	IN
cord-015021-pol2qm74	8368	4	alterations	alteration	NNS
cord-015021-pol2qm74	8368	5	in	in	IN
cord-015021-pol2qm74	8368	6	capillary	capillary	JJ
cord-015021-pol2qm74	8368	7	permeability	permeability	NN
cord-015021-pol2qm74	8368	8	seem	seem	VBP
cord-015021-pol2qm74	8368	9	to	to	TO
cord-015021-pol2qm74	8368	10	appear	appear	VB
cord-015021-pol2qm74	8368	11	:	:	:
cord-015021-pol2qm74	8368	12	1	1	LS
cord-015021-pol2qm74	8368	13	)	)	-RRB-
cord-015021-pol2qm74	8368	14	a	a	DT
cord-015021-pol2qm74	8368	15	temporary	temporary	JJ
cord-015021-pol2qm74	8368	16	short	short	JJ
cord-015021-pol2qm74	8368	17	increase	increase	NN
cord-015021-pol2qm74	8368	18	e.g.	e.g.	RB
cord-015021-pol2qm74	8368	19	in	in	IN
cord-015021-pol2qm74	8368	20	the	the	DT
cord-015021-pol2qm74	8368	21	proximal	proximal	JJ
cord-015021-pol2qm74	8368	22	small	small	JJ
cord-015021-pol2qm74	8368	23	intestine	intestine	NN
cord-015021-pol2qm74	8368	24	and	and	CC
cord-015021-pol2qm74	8368	25	spleen	spleen	NNS
cord-015021-pol2qm74	8368	26	;	;	:
cord-015021-pol2qm74	8368	27	2	2	LS
cord-015021-pol2qm74	8368	28	)	)	-RRB-
cord-015021-pol2qm74	8368	29	a	a	DT
cord-015021-pol2qm74	8368	30	temporary	temporary	JJ
cord-015021-pol2qm74	8368	31	longer	long	JJR
cord-015021-pol2qm74	8368	32	increase	increase	NN
cord-015021-pol2qm74	8368	33	e.g.	e.g.	RB
cord-015021-pol2qm74	8368	34	in	in	IN
cord-015021-pol2qm74	8368	35	the	the	DT
cord-015021-pol2qm74	8368	36	colon	colon	NN
cord-015021-pol2qm74	8368	37	and	and	CC
cord-015021-pol2qm74	8368	38	kidneys	kidney	NNS
cord-015021-pol2qm74	8368	39	;	;	:
cord-015021-pol2qm74	8368	40	3	3	LS
cord-015021-pol2qm74	8368	41	)	)	-RRB-
cord-015021-pol2qm74	8368	42	a	a	DT
cord-015021-pol2qm74	8368	43	persisting	persist	VBG
cord-015021-pol2qm74	8368	44	increase	increase	NN
cord-015021-pol2qm74	8368	45	e.g.	e.g.	RB
cord-015021-pol2qm74	8368	46	in	in	IN
cord-015021-pol2qm74	8368	47	the	the	DT
cord-015021-pol2qm74	8368	48	peritoneum	peritoneum	NN
cord-015021-pol2qm74	8368	49	,	,	,
cord-015021-pol2qm74	8368	50	cekum	cekum	NNP
cord-015021-pol2qm74	8368	51	,	,	,
cord-015021-pol2qm74	8368	52	distal	distal	JJ
cord-015021-pol2qm74	8368	53	small	small	JJ
cord-015021-pol2qm74	8368	54	intestine	intestine	NN
cord-015021-pol2qm74	8368	55	and	and	CC
cord-015021-pol2qm74	8368	56	lungs	lung	NNS
cord-015021-pol2qm74	8368	57	.	.	.
cord-015021-pol2qm74	8369	1	We	-PRON-	PRP
cord-015021-pol2qm74	8369	2	conclude	conclude	VBP
cord-015021-pol2qm74	8369	3	that	that	IN
cord-015021-pol2qm74	8369	4	experimentally	experimentally	RB
cord-015021-pol2qm74	8369	5	induced	induce	VBN
cord-015021-pol2qm74	8369	6	intraabdominal	intraabdominal	JJ
cord-015021-pol2qm74	8369	7	sepsis	sepsis	NN
cord-015021-pol2qm74	8369	8	induces	induce	VBZ
cord-015021-pol2qm74	8369	9	early	early	JJ
cord-015021-pol2qm74	8369	10	alterations	alteration	NNS
cord-015021-pol2qm74	8369	11	in	in	IN
cord-015021-pol2qm74	8369	12	capillary	capillary	JJ
cord-015021-pol2qm74	8369	13	permeability	permeability	NN
cord-015021-pol2qm74	8369	14	in	in	IN
cord-015021-pol2qm74	8369	15	multiple	multiple	JJ
cord-015021-pol2qm74	8369	16	organs	organ	NNS
cord-015021-pol2qm74	8369	17	and	and	CC
cord-015021-pol2qm74	8369	18	tissues	tissue	NNS
cord-015021-pol2qm74	8369	19	.	.	.
cord-015021-pol2qm74	8370	1	Such	such	JJ
cord-015021-pol2qm74	8370	2	changes	change	NNS
cord-015021-pol2qm74	8370	3	may	may	MD
cord-015021-pol2qm74	8370	4	contribute	contribute	VB
cord-015021-pol2qm74	8370	5	to	to	TO
cord-015021-pol2qm74	8370	6	explain	explain	VB
cord-015021-pol2qm74	8370	7	the	the	DT
cord-015021-pol2qm74	8370	8	development	development	NN
cord-015021-pol2qm74	8370	9	of	of	IN
cord-015021-pol2qm74	8370	10	sepsis	sepsis	NN
cord-015021-pol2qm74	8370	11	-	-	HYPH
cord-015021-pol2qm74	8370	12	induced	induce	VBN
cord-015021-pol2qm74	8370	13	multiple	multiple	JJ
cord-015021-pol2qm74	8370	14	organ	organ	NN
cord-015021-pol2qm74	8370	15	failure	failure	NN
cord-015021-pol2qm74	8370	16	.	.	.
cord-015021-pol2qm74	8371	1	Despite	despite	IN
cord-015021-pol2qm74	8371	2	a	a	DT
cord-015021-pol2qm74	8371	3	number	number	NN
cord-015021-pol2qm74	8371	4	of	of	IN
cord-015021-pol2qm74	8371	5	significant	significant	JJ
cord-015021-pol2qm74	8371	6	advances	advance	NNS
cord-015021-pol2qm74	8371	7	in	in	IN
cord-015021-pol2qm74	8371	8	the	the	DT
cord-015021-pol2qm74	8371	9	care	care	NN
cord-015021-pol2qm74	8371	10	of	of	IN
cord-015021-pol2qm74	8371	11	burn	burn	NN
cord-015021-pol2qm74	8371	12	and	and	CC
cord-015021-pol2qm74	8371	13	non	non	JJ
cord-015021-pol2qm74	8371	14	-	-	JJ
cord-015021-pol2qm74	8371	15	burn	burn	JJ
cord-015021-pol2qm74	8371	16	traumatic	traumatic	JJ
cord-015021-pol2qm74	8371	17	injury	injury	NN
cord-015021-pol2qm74	8371	18	,	,	,
cord-015021-pol2qm74	8371	19	infection	infection	NN
cord-015021-pol2qm74	8371	20	and	and	CC
cord-015021-pol2qm74	8371	21	sepsis	sepsis	NN
cord-015021-pol2qm74	8371	22	remain	remain	VBP
cord-015021-pol2qm74	8371	23	major	major	JJ
cord-015021-pol2qm74	8371	24	causes	cause	NNS
cord-015021-pol2qm74	8371	25	of	of	IN
cord-015021-pol2qm74	8371	26	morbidity	morbidity	NN
cord-015021-pol2qm74	8371	27	and	and	CC
cord-015021-pol2qm74	8371	28	mortality	mortality	NN
cord-015021-pol2qm74	8371	29	.	.	.
cord-015021-pol2qm74	8372	1	The	the	DT
cord-015021-pol2qm74	8372	2	severe	severe	JJ
cord-015021-pol2qm74	8372	3	immunosuppresslon	immunosuppresslon	NN
cord-015021-pol2qm74	8372	4	often	often	RB
cord-015021-pol2qm74	8372	5	seen	see	VBN
cord-015021-pol2qm74	8372	6	in	in	IN
cord-015021-pol2qm74	8372	7	patients	patient	NNS
cord-015021-pol2qm74	8372	8	with	with	IN
cord-015021-pol2qm74	8372	9	severe	severe	JJ
cord-015021-pol2qm74	8372	10	trauma	trauma	NN
cord-015021-pol2qm74	8372	11	or	or	CC
cord-015021-pol2qm74	8372	12	large	large	JJ
cord-015021-pol2qm74	8372	13	burns	burn	NNS
cord-015021-pol2qm74	8372	14	may	may	MD
cord-015021-pol2qm74	8372	15	predispose	predispose	VB
cord-015021-pol2qm74	8372	16	these	these	DT
cord-015021-pol2qm74	8372	17	patients	patient	NNS
cord-015021-pol2qm74	8372	18	to	to	IN
cord-015021-pol2qm74	8372	19	life	life	NN
cord-015021-pol2qm74	8372	20	threatening	threaten	VBG
cord-015021-pol2qm74	8372	21	infections	infection	NNS
cord-015021-pol2qm74	8372	22	.	.	.
cord-015021-pol2qm74	8373	1	Included	include	VBN
cord-015021-pol2qm74	8373	2	among	among	IN
cord-015021-pol2qm74	8373	3	the	the	DT
cord-015021-pol2qm74	8373	4	many	many	JJ
cord-015021-pol2qm74	8373	5	Immune	immune	JJ
cord-015021-pol2qm74	8373	6	alterations	alteration	NNS
cord-015021-pol2qm74	8373	7	are	be	VBP
cord-015021-pol2qm74	8373	8	changes	change	NNS
cord-015021-pol2qm74	8373	9	In	in	IN
cord-015021-pol2qm74	8373	10	the	the	DT
cord-015021-pol2qm74	8373	11	Functional	functional	JJ
cord-015021-pol2qm74	8373	12	capabilities	capability	NNS
cord-015021-pol2qm74	8373	13	of	of	IN
cord-015021-pol2qm74	8373	14	neutrophlls	neutrophlls	NNP
cord-015021-pol2qm74	8373	15	(	(	-LRB-
cord-015021-pol2qm74	8373	16	PMNs	PMNs	NNP
cord-015021-pol2qm74	8373	17	)	)	-RRB-
cord-015021-pol2qm74	8373	18	.	.	.
cord-015021-pol2qm74	8374	1	We	-PRON-	PRP
cord-015021-pol2qm74	8374	2	have	have	VBP
cord-015021-pol2qm74	8374	3	examined	examine	VBN
cord-015021-pol2qm74	8374	4	the	the	DT
cord-015021-pol2qm74	8374	5	expression	expression	NN
cord-015021-pol2qm74	8374	6	of	of	IN
cord-015021-pol2qm74	8374	7	the	the	DT
cord-015021-pol2qm74	8374	8	p	p	NN
cord-015021-pol2qm74	8374	9	2	2	CD
cord-015021-pol2qm74	8374	10	integrins	integrin	NNS
cord-015021-pol2qm74	8374	11	(	(	-LRB-
cord-015021-pol2qm74	8374	12	CD1	CD1	NNP
cord-015021-pol2qm74	8374	13	l	l	NNP
cord-015021-pol2qm74	8374	14	a	a	NNP
cord-015021-pol2qm74	8374	15	,	,	,
cord-015021-pol2qm74	8374	16	b	b	NN
cord-015021-pol2qm74	8374	17	,	,	,
cord-015021-pol2qm74	8374	18	c	c	NNP
cord-015021-pol2qm74	8374	19	/	/	SYM
cord-015021-pol2qm74	8374	20	CD18	CD18	NNP
cord-015021-pol2qm74	8374	21	)	)	-RRB-
cord-015021-pol2qm74	8374	22	,	,	,
cord-015021-pol2qm74	8374	23	and	and	CC
cord-015021-pol2qm74	8374	24	the	the	DT
cord-015021-pol2qm74	8374	25	Fc'?R	Fc'?R	NNS
cord-015021-pol2qm74	8374	26	(	(	-LRB-
cord-015021-pol2qm74	8374	27	CD16	CD16	NNP
cord-015021-pol2qm74	8374	28	,	,	,
cord-015021-pol2qm74	8374	29	CD32	CD32	NNP
cord-015021-pol2qm74	8374	30	,	,	,
cord-015021-pol2qm74	8374	31	and	and	CC
cord-015021-pol2qm74	8374	32	CD64	CD64	NNP
cord-015021-pol2qm74	8374	33	)	)	-RRB-
cord-015021-pol2qm74	8374	34	,	,	,
cord-015021-pol2qm74	8374	35	as	as	RB
cord-015021-pol2qm74	8374	36	well	well	RB
cord-015021-pol2qm74	8374	37	as	as	IN
cord-015021-pol2qm74	8374	38	several	several	JJ
cord-015021-pol2qm74	8374	39	functional	functional	JJ
cord-015021-pol2qm74	8374	40	parameters	parameter	NNS
cord-015021-pol2qm74	8374	41	,	,	,
cord-015021-pol2qm74	8374	42	on	on	IN
cord-015021-pol2qm74	8374	43	PMNs	pmn	NNS
cord-015021-pol2qm74	8374	44	from	from	IN
cord-015021-pol2qm74	8374	45	thermal	thermal	JJ
cord-015021-pol2qm74	8374	46	and	and	CC
cord-015021-pol2qm74	8374	47	non	non	JJ
cord-015021-pol2qm74	8374	48	-	-	JJ
cord-015021-pol2qm74	8374	49	thermal	thermal	JJ
cord-015021-pol2qm74	8374	50	traumatic	traumatic	JJ
cord-015021-pol2qm74	8374	51	injury	injury	NN
cord-015021-pol2qm74	8374	52	,	,	,
cord-015021-pol2qm74	8374	53	PMNs	PMNs	NNP
cord-015021-pol2qm74	8374	54	were	be	VBD
cord-015021-pol2qm74	8374	55	obtained	obtain	VBN
cord-015021-pol2qm74	8374	56	from	from	IN
cord-015021-pol2qm74	8374	57	patients	patient	NNS
cord-015021-pol2qm74	8374	58	sustaining	sustain	VBG
cord-015021-pol2qm74	8374	59	severe	severe	JJ
cord-015021-pol2qm74	8374	60	trauma	trauma	NN
cord-015021-pol2qm74	8374	61	(	(	-LRB-
cord-015021-pol2qm74	8374	62	initial	initial	JJ
cord-015021-pol2qm74	8374	63	APACHE	APACHE	NNP
cord-015021-pol2qm74	8374	64	II	II	NNP
cord-015021-pol2qm74	8374	65	score	score	NN
cord-015021-pol2qm74	8374	66	>	>	XX
cord-015021-pol2qm74	8374	67	10	10	CD
cord-015021-pol2qm74	8374	68	)	)	-RRB-
cord-015021-pol2qm74	8374	69	or	or	CC
cord-015021-pol2qm74	8374	70	thermal	thermal	JJ
cord-015021-pol2qm74	8374	71	injury	injury	NN
cord-015021-pol2qm74	8374	72	(	(	-LRB-
cord-015021-pol2qm74	8374	73	>	>	NFP
cord-015021-pol2qm74	8374	74	30~	30~	CD
cord-015021-pol2qm74	8374	75	total	total	JJ
cord-015021-pol2qm74	8374	76	body	body	NN
cord-015021-pol2qm74	8374	77	surface	surface	NN
cord-015021-pol2qm74	8374	78	area	area	NN
cord-015021-pol2qm74	8374	79	,	,	,
cord-015021-pol2qm74	8374	80	15	15	CD
cord-015021-pol2qm74	8374	81	%	%	NN
cord-015021-pol2qm74	8374	82	full	full	JJ
cord-015021-pol2qm74	8374	83	thickness	thickness	NN
cord-015021-pol2qm74	8374	84	)	)	-RRB-
cord-015021-pol2qm74	8374	85	,	,	,
cord-015021-pol2qm74	8374	86	and	and	CC
cord-015021-pol2qm74	8374	87	healthy	healthy	JJ
cord-015021-pol2qm74	8374	88	controls	control	NNS
cord-015021-pol2qm74	8374	89	.	.	.
cord-015021-pol2qm74	8375	1	The	the	DT
cord-015021-pol2qm74	8375	2	expression	expression	NN
cord-015021-pol2qm74	8375	3	of	of	IN
cord-015021-pol2qm74	8375	4	CD11	CD11	NNP
cord-015021-pol2qm74	8375	5	b	b	NNP
cord-015021-pol2qm74	8375	6	and	and	CC
cord-015021-pol2qm74	8375	7	c	c	NN
cord-015021-pol2qm74	8375	8	and	and	CC
cord-015021-pol2qm74	8375	9	to	to	IN
cord-015021-pol2qm74	8375	10	a	a	DT
cord-015021-pol2qm74	8375	11	lesser	less	JJR
cord-015021-pol2qm74	8375	12	degree	degree	NN
cord-015021-pol2qm74	8375	13	CDI	cdi	NN
cord-015021-pol2qm74	8375	14	1	1	CD
cord-015021-pol2qm74	8375	15	a	a	DT
cord-015021-pol2qm74	8375	16	was	be	VBD
cord-015021-pol2qm74	8375	17	significantly	significantly	RB
cord-015021-pol2qm74	8375	18	reduced	reduce	VBN
cord-015021-pol2qm74	8375	19	on	on	IN
cord-015021-pol2qm74	8375	20	PMNs	pmn	NNS
cord-015021-pol2qm74	8375	21	.	.	.
cord-015021-pol2qm74	8376	1	The	the	DT
cord-015021-pol2qm74	8376	2	expression	expression	NN
cord-015021-pol2qm74	8376	3	of	of	IN
cord-015021-pol2qm74	8376	4	CD16	CD16	NNP
cord-015021-pol2qm74	8376	5	and	and	CC
cord-015021-pol2qm74	8376	6	CD32	CD32	NNP
cord-015021-pol2qm74	8376	7	but	but	CC
cord-015021-pol2qm74	8376	8	not	not	RB
cord-015021-pol2qm74	8376	9	CD64	CD64	NNP
cord-015021-pol2qm74	8376	10	was	be	VBD
cord-015021-pol2qm74	8376	11	also	also	RB
cord-015021-pol2qm74	8376	12	significantly	significantly	RB
cord-015021-pol2qm74	8376	13	reduced	reduce	VBN
cord-015021-pol2qm74	8376	14	.	.	.
cord-015021-pol2qm74	8377	1	PMNs	pmn	NNS
cord-015021-pol2qm74	8377	2	displaying	display	VBG
cord-015021-pol2qm74	8377	3	this	this	DT
cord-015021-pol2qm74	8377	4	reduction	reduction	NN
cord-015021-pol2qm74	8378	1	In	in	IN
cord-015021-pol2qm74	8378	2	receptor	receptor	NN
cord-015021-pol2qm74	8378	3	expression	expression	NN
cord-015021-pol2qm74	8378	4	have	have	VBP
cord-015021-pol2qm74	8378	5	a	a	DT
cord-015021-pol2qm74	8378	6	significantly	significantly	RB
cord-015021-pol2qm74	8378	7	reduced	reduce	VBN
cord-015021-pol2qm74	8378	8	ability	ability	NN
cord-015021-pol2qm74	8378	9	to	to	IN
cord-015021-pol2qm74	8378	10	phagocytose	phagocytose	JJ
cord-015021-pol2qm74	8378	11	bacteria	bacteria	NNS
cord-015021-pol2qm74	8378	12	and	and	CC
cord-015021-pol2qm74	8378	13	undergo	undergo	VB
cord-015021-pol2qm74	8378	14	the	the	DT
cord-015021-pol2qm74	8378	15	oxidative	oxidative	JJ
cord-015021-pol2qm74	8378	16	metabolic	metabolic	JJ
cord-015021-pol2qm74	8378	17	burst	burst	NN
cord-015021-pol2qm74	8378	18	response	response	NN
cord-015021-pol2qm74	8378	19	.	.	.
cord-015021-pol2qm74	8379	1	Thermal	thermal	JJ
cord-015021-pol2qm74	8379	2	and	and	CC
cord-015021-pol2qm74	8379	3	traumatic	traumatic	JJ
cord-015021-pol2qm74	8379	4	injury	injury	NN
cord-015021-pol2qm74	8379	5	result	result	NN
cord-015021-pol2qm74	8380	1	In	in	IN
cord-015021-pol2qm74	8380	2	global	global	JJ
cord-015021-pol2qm74	8380	3	reduction	reduction	NN
cord-015021-pol2qm74	8380	4	in	in	IN
cord-015021-pol2qm74	8380	5	the	the	DT
cord-015021-pol2qm74	8380	6	expression	expression	NN
cord-015021-pol2qm74	8380	7	of	of	IN
cord-015021-pol2qm74	8380	8	132	132	CD
cord-015021-pol2qm74	8380	9	integrins	integrin	NNS
cord-015021-pol2qm74	8380	10	and	and	CC
cord-015021-pol2qm74	8380	11	FoR	for	IN
cord-015021-pol2qm74	8380	12	which	which	WDT
cord-015021-pol2qm74	8380	13	may	may	MD
cord-015021-pol2qm74	8380	14	lead	lead	VB
cord-015021-pol2qm74	8380	15	to	to	IN
cord-015021-pol2qm74	8380	16	decreased	decrease	VBN
cord-015021-pol2qm74	8380	17	functional	functional	JJ
cord-015021-pol2qm74	8380	18	capabilities	capability	NNS
cord-015021-pol2qm74	8380	19	,	,	,
cord-015021-pol2qm74	8380	20	These	these	DT
cord-015021-pol2qm74	8380	21	abnormalities	abnormality	NNS
cord-015021-pol2qm74	8380	22	may	may	MD
cord-015021-pol2qm74	8380	23	In	in	IN
cord-015021-pol2qm74	8380	24	turn	turn	NN
cord-015021-pol2qm74	8380	25	account	account	NN
cord-015021-pol2qm74	8381	1	at	at	IN
cord-015021-pol2qm74	8381	2	least	least	JJS
cord-015021-pol2qm74	8381	3	In	in	IN
cord-015021-pol2qm74	8381	4	part	part	NN
cord-015021-pol2qm74	8381	5	for	for	IN
cord-015021-pol2qm74	8381	6	the	the	DT
cord-015021-pol2qm74	8381	7	Increased	increase	VBN
cord-015021-pol2qm74	8381	8	rate	rate	NN
cord-015021-pol2qm74	8381	9	of	of	IN
cord-015021-pol2qm74	8381	10	Infection	infection	NN
cord-015021-pol2qm74	8381	11	in	in	IN
cord-015021-pol2qm74	8381	12	these	these	DT
cord-015021-pol2qm74	8381	13	patlems	patlem	NNS
cord-015021-pol2qm74	8381	14	,	,	,
cord-015021-pol2qm74	8381	15	Institute	Institute	NNP
cord-015021-pol2qm74	8381	16	,	,	,
cord-015021-pol2qm74	8381	17	Dept	Dept	NNP
cord-015021-pol2qm74	8381	18	.	.	NNP
cord-015021-pol2qm74	8381	19	of	of	IN
cord-015021-pol2qm74	8381	20	Surgery	surgery	NN
cord-015021-pol2qm74	8381	21	,	,	,
cord-015021-pol2qm74	8381	22	2~1	2~1	CD
cord-015021-pol2qm74	8381	23	8ethesda	8ethesda	CD
cord-015021-pol2qm74	8381	24	Ave	Ave	NNP
cord-015021-pol2qm74	8381	25	,	,	,
cord-015021-pol2qm74	8381	26	Cincinnalt	Cincinnalt	NNP
cord-015021-pol2qm74	8381	27	,	,	,
cord-015021-pol2qm74	8381	28	OH	oh	UH
cord-015021-pol2qm74	8381	29	,	,	,
cord-015021-pol2qm74	8381	30	USA	USA	NNP
cord-015021-pol2qm74	8381	31	,	,	,
cord-015021-pol2qm74	8381	32	45267	45267	CD
cord-015021-pol2qm74	8381	33	-	-	SYM
cord-015021-pol2qm74	8381	34	0S5B	0s5b	CD
cord-015021-pol2qm74	8381	35	,	,	,
cord-015021-pol2qm74	8381	36	Antibiotic	antibiotic	JJ
cord-015021-pol2qm74	8381	37	-	-	HYPH
cord-015021-pol2qm74	8381	38	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	8381	39	cell	cell	NN
cord-015021-pol2qm74	8381	40	interactions	interaction	NNS
cord-015021-pol2qm74	8381	41	:	:	:
cord-015021-pol2qm74	8381	42	their	-PRON-	PRP$
cord-015021-pol2qm74	8381	43	effect	effect	NN
cord-015021-pol2qm74	8381	44	on	on	IN
cord-015021-pol2qm74	8381	45	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8381	46	release	release	NN
cord-015021-pol2qm74	8381	47	.	.	.
cord-015021-pol2qm74	8382	1	C	c	NN
cord-015021-pol2qm74	8382	2	G	g	NN
cord-015021-pol2qm74	8382	3	C	c	NN
cord-015021-pol2qm74	8382	4	-	-	HYPH
cord-015021-pol2qm74	8382	5	emmet1	emmet1	NN
cord-015021-pol2qm74	8382	6	,	,	,
cord-015021-pol2qm74	8382	7	Dep[Baeteriolog.z	dep[baeteriolog.z	NN
cord-015021-pol2qm74	8382	8	,	,	,
cord-015021-pol2qm74	8382	9	Univer_sitv	univer_sitv	NN
cord-015021-pol2qm74	8382	10	of	of	IN
cord-015021-pol2qm74	8382	11	Glasgow	Glasgow	NNP
cord-015021-pol2qm74	8382	12	,	,	,
cord-015021-pol2qm74	8383	1	Scotlan~_d	Scotlan~_d	NNP
cord-015021-pol2qm74	8384	1	Increasingly	increasingly	RB
cord-015021-pol2qm74	8384	2	it	-PRON-	PRP
cord-015021-pol2qm74	8384	3	is	be	VBZ
cord-015021-pol2qm74	8384	4	recognised	recognise	VBN
cord-015021-pol2qm74	8384	5	that	that	IN
cord-015021-pol2qm74	8384	6	pathogenic	pathogenic	JJ
cord-015021-pol2qm74	8384	7	bacteria	bacteria	NNS
cord-015021-pol2qm74	8384	8	are	be	VBP
cord-015021-pol2qm74	8384	9	capable	capable	JJ
cord-015021-pol2qm74	8384	10	of	of	IN
cord-015021-pol2qm74	8384	11	surviving	survive	VBG
cord-015021-pol2qm74	8384	12	intracellularly	intracellularly	RB
cord-015021-pol2qm74	8384	13	within	within	IN
cord-015021-pol2qm74	8384	14	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	8384	15	cells	cell	NNS
cord-015021-pol2qm74	8384	16	in	in	IN
cord-015021-pol2qm74	8384	17	addition	addition	NN
cord-015021-pol2qm74	8384	18	to	to	IN
cord-015021-pol2qm74	8384	19	their	-PRON-	PRP$
cord-015021-pol2qm74	8384	20	capacity	capacity	NN
cord-015021-pol2qm74	8384	21	to	to	TO
cord-015021-pol2qm74	8384	22	produce	produce	VB
cord-015021-pol2qm74	8384	23	disease	disease	NN
cord-015021-pol2qm74	8384	24	whilst	whilst	IN
cord-015021-pol2qm74	8384	25	in	in	IN
cord-015021-pol2qm74	8384	26	the	the	DT
cord-015021-pol2qm74	8384	27	extracellular	extracellular	JJ
cord-015021-pol2qm74	8384	28	milieu	milieu	NN
cord-015021-pol2qm74	8384	29	.	.	.
cord-015021-pol2qm74	8385	1	As	as	RB
cord-015021-pol2qm74	8385	2	well	well	RB
cord-015021-pol2qm74	8385	3	as	as	IN
cord-015021-pol2qm74	8385	4	providing	provide	VBG
cord-015021-pol2qm74	8385	5	protection	protection	NN
cord-015021-pol2qm74	8385	6	from	from	IN
cord-015021-pol2qm74	8385	7	certain	certain	JJ
cord-015021-pol2qm74	8385	8	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	8385	9	which	which	WDT
cord-015021-pol2qm74	8385	10	fail	fail	VBP
cord-015021-pol2qm74	8385	11	to	to	TO
cord-015021-pol2qm74	8385	12	penetrate	penetrate	VB
cord-015021-pol2qm74	8385	13	the	the	DT
cord-015021-pol2qm74	8385	14	phagocyte	phagocyte	NNS
cord-015021-pol2qm74	8385	15	,	,	,
cord-015021-pol2qm74	8385	16	such	such	JJ
cord-015021-pol2qm74	8385	17	intraceltular	intraceltular	JJ
cord-015021-pol2qm74	8385	18	bacteria	bacteria	NNS
cord-015021-pol2qm74	8385	19	may	may	MD
cord-015021-pol2qm74	8385	20	be	be	VB
cord-015021-pol2qm74	8385	21	transported	transport	VBN
cord-015021-pol2qm74	8385	22	from	from	IN
cord-015021-pol2qm74	8385	23	the	the	DT
cord-015021-pol2qm74	8385	24	initial	initial	JJ
cord-015021-pol2qm74	8385	25	site	site	NN
cord-015021-pol2qm74	8385	26	of	of	IN
cord-015021-pol2qm74	8385	27	infection	infection	NN
cord-015021-pol2qm74	8385	28	to	to	IN
cord-015021-pol2qm74	8385	29	a	a	DT
cord-015021-pol2qm74	8385	30	distant	distant	JJ
cord-015021-pol2qm74	8385	31	more	more	RBR
cord-015021-pol2qm74	8385	32	vulnerable	vulnerable	JJ
cord-015021-pol2qm74	8385	33	body	body	NN
cord-015021-pol2qm74	8385	34	site	site	NN
cord-015021-pol2qm74	8385	35	wherein	wherein	WRB
cord-015021-pol2qm74	8385	36	they	-PRON-	PRP
cord-015021-pol2qm74	8385	37	may	may	MD
cord-015021-pol2qm74	8385	38	proliferate	proliferate	VB
cord-015021-pol2qm74	8385	39	.	.	.
cord-015021-pol2qm74	8386	1	It	-PRON-	PRP
cord-015021-pol2qm74	8386	2	is	be	VBZ
cord-015021-pol2qm74	8386	3	also	also	RB
cord-015021-pol2qm74	8386	4	known	know	VBN
cord-015021-pol2qm74	8386	5	that	that	IN
cord-015021-pol2qm74	8386	6	some	some	DT
cord-015021-pol2qm74	8386	7	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	8386	8	are	be	VBP
cord-015021-pol2qm74	8386	9	capable	capable	JJ
cord-015021-pol2qm74	8386	10	of	of	IN
cord-015021-pol2qm74	8386	11	becoming	become	VBG
cord-015021-pol2qm74	8386	12	concentrated	concentrated	JJ
cord-015021-pol2qm74	8386	13	within	within	IN
cord-015021-pol2qm74	8386	14	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	8386	15	cells	cell	NNS
cord-015021-pol2qm74	8386	16	mid	mid	IN
cord-015021-pol2qm74	8386	17	displaying	display	VBG
cord-015021-pol2qm74	8386	18	bioactivity	bioactivity	NN
cord-015021-pol2qm74	8386	19	therein	therein	RB
cord-015021-pol2qm74	8386	20	.	.	.
cord-015021-pol2qm74	8387	1	Such	such	JJ
cord-015021-pol2qm74	8387	2	bioactivity	bioactivity	NN
cord-015021-pol2qm74	8387	3	might	may	MD
cord-015021-pol2qm74	8387	4	be	be	VB
cord-015021-pol2qm74	8387	5	responsible	responsible	JJ
cord-015021-pol2qm74	8387	6	for	for	IN
cord-015021-pol2qm74	8387	7	the	the	DT
cord-015021-pol2qm74	8387	8	release	release	NN
cord-015021-pol2qm74	8387	9	of	of	IN
cord-015021-pol2qm74	8387	10	endotoxia	endotoxia	NN
cord-015021-pol2qm74	8387	11	#	#	$
cord-015021-pol2qm74	8387	12	orn	orn	VBN
cord-015021-pol2qm74	8387	13	gram	gram	NN
cord-015021-pol2qm74	8387	14	-	-	HYPH
cord-015021-pol2qm74	8387	15	negative	negative	JJ
cord-015021-pol2qm74	8387	16	bacteria	bacteria	NNS
cord-015021-pol2qm74	8387	17	which	which	WDT
cord-015021-pol2qm74	8387	18	when	when	WRB
cord-015021-pol2qm74	8387	19	liberated	liberate	VBN
cord-015021-pol2qm74	8387	20	from	from	IN
cord-015021-pol2qm74	8387	21	the	the	DT
cord-015021-pol2qm74	8387	22	celt	celt	NN
cord-015021-pol2qm74	8387	23	could	could	MD
cord-015021-pol2qm74	8387	24	~gger	~gger	NNP
cord-015021-pol2qm74	8387	25	the	the	DT
cord-015021-pol2qm74	8387	26	cytokine	cytokine	NN
cord-015021-pol2qm74	8387	27	cascade	cascade	NN
cord-015021-pol2qm74	8387	28	.	.	.
cord-015021-pol2qm74	8388	1	Anfib	Anfib	NNP
cord-015021-pol2qm74	8388	2	,	,	,
cord-015021-pol2qm74	8388	3	.	.	.
cord-015021-pol2qm74	8389	1	'	'	``
cord-015021-pol2qm74	8389	2	otic	otic	NN
cord-015021-pol2qm74	8389	3	-	-	HYPH
cord-015021-pol2qm74	8389	4	induced	induce	VBN
cord-015021-pol2qm74	8389	5	damage	damage	NN
cord-015021-pol2qm74	8389	6	to	to	IN
cord-015021-pol2qm74	8389	7	the	the	DT
cord-015021-pol2qm74	8389	8	ultrastructure	ultrastructure	NN
cord-015021-pol2qm74	8389	9	of	of	IN
cord-015021-pol2qm74	8389	10	bacteria	bacteria	NNS
cord-015021-pol2qm74	8389	11	can	can	MD
cord-015021-pol2qm74	8389	12	also	also	RB
cord-015021-pol2qm74	8389	13	occur	occur	VB
cord-015021-pol2qm74	8389	14	when	when	WRB
cord-015021-pol2qm74	8389	15	the	the	DT
cord-015021-pol2qm74	8389	16	target	target	NN
cord-015021-pol2qm74	8389	17	bacteria	bacteria	NNS
cord-015021-pol2qm74	8389	18	are	be	VBP
cord-015021-pol2qm74	8389	19	exposed	expose	VBN
cord-015021-pol2qm74	8389	20	to	to	IN
cord-015021-pol2qm74	8389	21	low	low	JJ
cord-015021-pol2qm74	8389	22	(	(	-LRB-
cord-015021-pol2qm74	8389	23	sub	sub	NN
cord-015021-pol2qm74	8389	24	-	-	HYPH
cord-015021-pol2qm74	8389	25	MIC	MIC	NNP
cord-015021-pol2qm74	8389	26	)	)	-RRB-
cord-015021-pol2qm74	8389	27	concentrations	concentration	NNS
cord-015021-pol2qm74	8389	28	of	of	IN
cord-015021-pol2qm74	8389	29	certain	certain	JJ
cord-015021-pol2qm74	8389	30	drugs	drug	NNS
cord-015021-pol2qm74	8389	31	.	.	.
cord-015021-pol2qm74	8390	1	Such	such	JJ
cord-015021-pol2qm74	8390	2	bacteria	bacteria	NNS
cord-015021-pol2qm74	8390	3	may	may	MD
cord-015021-pol2qm74	8390	4	present	present	VB
cord-015021-pol2qm74	8390	5	quite	quite	RB
cord-015021-pol2qm74	8390	6	altered	alter	VBN
cord-015021-pol2qm74	8390	7	surface	surface	NN
cord-015021-pol2qm74	8390	8	components	component	NNS
cord-015021-pol2qm74	8390	9	m	m	NNP
cord-015021-pol2qm74	8390	10	host	host	NN
cord-015021-pol2qm74	8390	11	-	-	HYPH
cord-015021-pol2qm74	8390	12	defense	defense	NN
cord-015021-pol2qm74	8390	13	cells	cell	NNS
cord-015021-pol2qm74	8390	14	as	as	RB
cord-015021-pol2qm74	8390	15	well	well	RB
cord-015021-pol2qm74	8390	16	as	as	IN
cord-015021-pol2qm74	8390	17	releasing	release	VBG
cord-015021-pol2qm74	8390	18	biologically	biologically	RB
cord-015021-pol2qm74	8390	19	active	active	JJ
cord-015021-pol2qm74	8390	20	ceil	ceil	NN
cord-015021-pol2qm74	8390	21	wall	wall	NN
cord-015021-pol2qm74	8390	22	components	component	NNS
cord-015021-pol2qm74	8390	23	such	such	JJ
cord-015021-pol2qm74	8390	24	as	as	IN
cord-015021-pol2qm74	8390	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8390	26	.	.	.
cord-015021-pol2qm74	8391	1	The	the	DT
cord-015021-pol2qm74	8391	2	nature	nature	NN
cord-015021-pol2qm74	8391	3	of	of	IN
cord-015021-pol2qm74	8391	4	these	these	DT
cord-015021-pol2qm74	8391	5	interactions	interaction	NNS
cord-015021-pol2qm74	8391	6	at	at	IN
cord-015021-pol2qm74	8391	7	the	the	DT
cord-015021-pol2qm74	8391	8	cellular	cellular	JJ
cord-015021-pol2qm74	8391	9	level	level	NN
cord-015021-pol2qm74	8391	10	as	as	RB
cord-015021-pol2qm74	8391	11	well	well	RB
cord-015021-pol2qm74	8391	12	as	as	IN
cord-015021-pol2qm74	8391	13	the	the	DT
cord-015021-pol2qm74	8391	14	consequences	consequence	NNS
cord-015021-pol2qm74	8391	15	for	for	IN
cord-015021-pol2qm74	8391	16	the	the	DT
cord-015021-pol2qm74	8391	17	host	host	NN
cord-015021-pol2qm74	8391	18	will	will	MD
cord-015021-pol2qm74	8391	19	be	be	VB
cord-015021-pol2qm74	8391	20	discussed	discuss	VBN
cord-015021-pol2qm74	8391	21	.	.	.
cord-015021-pol2qm74	8392	1	New	New	NNP
cord-015021-pol2qm74	8392	2	Jersey	Jersey	NNP
cord-015021-pol2qm74	8392	3	Medical	Medical	NNP
cord-015021-pol2qm74	8392	4	School	School	NNP
cord-015021-pol2qm74	8392	5	:	:	:
cord-015021-pol2qm74	8392	6	UMD	UMD	NNP
cord-015021-pol2qm74	8392	7	,	,	,
cord-015021-pol2qm74	8392	8	Newark	Newark	NNP
cord-015021-pol2qm74	8392	9	,	,	,
cord-015021-pol2qm74	8392	10	NJ	NJ	NNP
cord-015021-pol2qm74	8392	11	07107	07107	CD
cord-015021-pol2qm74	8393	1	A	a	DT
cord-015021-pol2qm74	8393	2	technique	technique	NN
cord-015021-pol2qm74	8393	3	of	of	IN
cord-015021-pol2qm74	8393	4	physiologic	physiologic	JJ
cord-015021-pol2qm74	8393	5	state	state	NN
cord-015021-pol2qm74	8393	6	classification	classification	NN
cord-015021-pol2qm74	8393	7	has	have	VBZ
cord-015021-pol2qm74	8393	8	been	be	VBN
cord-015021-pol2qm74	8393	9	developed	develop	VBN
cord-015021-pol2qm74	8393	10	based	base	VBN
cord-015021-pol2qm74	8393	11	on	on	IN
cord-015021-pol2qm74	8393	12	the	the	DT
cord-015021-pol2qm74	8393	13	m	m	NNP
cord-015021-pol2qm74	8393	14	~	~	NFP
cord-015021-pol2qm74	8393	15	itlvariable	itlvariable	NNP
cord-015021-pol2qm74	8393	16	analysis	analysis	NN
cord-015021-pol2qm74	8393	17	of	of	IN
cord-015021-pol2qm74	8393	18	patient	patient	JJ
cord-015021-pol2qm74	8393	19	derived	derive	VBN
cord-015021-pol2qm74	8393	20	data	data	NN
cord-015021-pol2qm74	8393	21	sets	set	NNS
cord-015021-pol2qm74	8393	22	of	of	IN
cord-015021-pol2qm74	8393	23	seventeen	seventeen	CD
cord-015021-pol2qm74	8393	24	physiologic	physiologic	JJ
cord-015021-pol2qm74	8393	25	variables	variable	NNS
cord-015021-pol2qm74	8393	26	.	.	.
cord-015021-pol2qm74	8394	1	These	these	DT
cord-015021-pol2qm74	8394	2	multivariable	multivariable	JJ
cord-015021-pol2qm74	8394	3	data	data	NN
cord-015021-pol2qm74	8394	4	sets	set	NNS
cord-015021-pol2qm74	8394	5	obtained	obtain	VBN
cord-015021-pol2qm74	8394	6	from	from	IN
cord-015021-pol2qm74	8394	7	critically	critically	RB
cord-015021-pol2qm74	8394	8	ill	ill	JJ
cord-015021-pol2qm74	8394	9	patients	patient	NNS
cord-015021-pol2qm74	8394	10	requiring	require	VBG
cord-015021-pol2qm74	8394	11	Intensive	intensive	JJ
cord-015021-pol2qm74	8394	12	care	care	NN
cord-015021-pol2qm74	8394	13	,	,	,
cord-015021-pol2qm74	8394	14	were	be	VBD
cord-015021-pol2qm74	8394	15	aormallsed	aormallse	VBN
cord-015021-pol2qm74	8394	16	by	by	IN
cord-015021-pol2qm74	8394	17	the	the	DT
cord-015021-pol2qm74	8394	18	mean	mean	NN
cord-015021-pol2qm74	8394	19	and	and	CC
cord-015021-pol2qm74	8394	20	the	the	DT
cord-015021-pol2qm74	8394	21	standard	standard	JJ
cord-015021-pol2qm74	8394	22	deviation	deviation	NN
cord-015021-pol2qm74	8394	23	of	of	IN
cord-015021-pol2qm74	8394	24	recoverin~	recoverin~	NNP
cord-015021-pol2qm74	8394	25	Trauma	trauma	NN
cord-015021-pol2qm74	8394	26	patients	patient	NNS
cord-015021-pol2qm74	8394	27	who	who	WP
cord-015021-pol2qm74	8394	28	were	be	VBD
cord-015021-pol2qm74	8394	29	not	not	RB
cord-015021-pol2qm74	8394	30	critically	critically	RB
cord-015021-pol2qm74	8394	31	Ill	Ill	NNP
cord-015021-pol2qm74	8394	32	,	,	,
cord-015021-pol2qm74	8394	33	The	the	DT
cord-015021-pol2qm74	8394	34	resulting	result	VBG
cord-015021-pol2qm74	8394	35	normalized	normalize	VBN
cord-015021-pol2qm74	8394	36	seventeen	seventeen	CD
cord-015021-pol2qm74	8394	37	variable	variable	JJ
cord-015021-pol2qm74	8394	38	sets	set	NNS
cord-015021-pol2qm74	8394	39	were	be	VBD
cord-015021-pol2qm74	8394	40	then	then	RB
cord-015021-pol2qm74	8394	41	clustered	cluster	VBN
cord-015021-pol2qm74	8394	42	.	.	.
cord-015021-pol2qm74	8395	1	Seven	seven	CD
cord-015021-pol2qm74	8395	2	independent	independent	JJ
cord-015021-pol2qm74	8395	3	data	datum	NNS
cord-015021-pol2qm74	8395	4	groupings	grouping	NNS
cord-015021-pol2qm74	8395	5	were	be	VBD
cord-015021-pol2qm74	8395	6	developed	develop	VBN
cord-015021-pol2qm74	8395	7	.	.	.
cord-015021-pol2qm74	8396	1	The	the	DT
cord-015021-pol2qm74	8396	2	normal	normal	JJ
cord-015021-pol2qm74	8396	3	stress	stress	NN
cord-015021-pol2qm74	8396	4	response	response	NN
cord-015021-pol2qm74	8396	5	hyperdynamic	hyperdynamic	JJ
cord-015021-pol2qm74	8396	6	state	state	NN
cord-015021-pol2qm74	8396	7	seen	see	VBD
cord-015021-pol2qm74	8396	8	post	post	NN
cord-015021-pol2qm74	8396	9	-	-	NNP
cord-015021-pol2qm74	8396	10	Trauma	trauma	NN
cord-015021-pol2qm74	8396	11	and	and	CC
cord-015021-pol2qm74	8396	12	in	in	IN
cord-015021-pol2qm74	8396	13	compensated	compensate	VBN
cord-015021-pol2qm74	8396	14	sepsis	sepsis	NN
cord-015021-pol2qm74	8397	1	(	(	-LRB-
cord-015021-pol2qm74	8397	2	A	a	DT
cord-015021-pol2qm74	8397	3	Stets)/	Stets)/	NNP
cord-015021-pol2qm74	8397	4	metabolic	metabolic	JJ
cord-015021-pol2qm74	8397	5	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8397	6	seen	see	VBN
cord-015021-pol2qm74	8397	7	in	in	IN
cord-015021-pol2qm74	8397	8	septic	septic	JJ
cord-015021-pol2qm74	8397	9	decompsnsation	decompsnsation	NN
cord-015021-pol2qm74	8397	10	(	(	-LRB-
cord-015021-pol2qm74	8397	11	B	B	NNP
cord-015021-pol2qm74	8397	12	StSte	StSte	NNP
cord-015021-pol2qm74	8397	13	}	}	-RRB-
cord-015021-pol2qm74	8397	14	;	;	:
cord-015021-pol2qm74	8397	15	early	early	JJ
cord-015021-pol2qm74	8397	16	(	(	-LRB-
cord-015021-pol2qm74	8397	17	C	C	NNP
cord-015021-pol2qm74	8397	18	,	,	,
cord-015021-pol2qm74	8397	19	)	)	-RRB-
cord-015021-pol2qm74	8397	20	and	and	CC
cord-015021-pol2qm74	8397	21	late	late	JJ
cord-015021-pol2qm74	8397	22	(	(	-LRB-
cord-015021-pol2qm74	8397	23	e2	e2	NN
cord-015021-pol2qm74	8397	24	)	)	-RRB-
cord-015021-pol2qm74	8397	25	respiratory	respiratory	JJ
cord-015021-pol2qm74	8397	26	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8397	27	associated	associate	VBN
cord-015021-pol2qm74	8397	28	with	with	IN
cord-015021-pol2qm74	8397	29	ARDS	ARDS	NNP
cord-015021-pol2qm74	8397	30	;	;	:
cord-015021-pol2qm74	8397	31	cardlogenlc	cardlogenlc	NNP
cord-015021-pol2qm74	8397	32	dscompensation	dscompensation	NNP
cord-015021-pol2qm74	8397	33	(	(	-LRB-
cord-015021-pol2qm74	8397	34	n	n	NNP
cord-015021-pol2qm74	8397	35	State	State	NNP
cord-015021-pol2qm74	8397	36	)	)	-RRB-
cord-015021-pol2qm74	8397	37	;	;	:
cord-015021-pol2qm74	8397	38	post	post	JJ
cord-015021-pol2qm74	8397	39	-	-	JJ
cord-015021-pol2qm74	8397	40	Trauma	trauma	JJ
cord-015021-pol2qm74	8397	41	hyvolemla	hyvolemla	NN
cord-015021-pol2qm74	8397	42	without	without	IN
cord-015021-pol2qm74	8397	43	shock	shock	NN
cord-015021-pol2qm74	8397	44	(	(	-LRB-
cord-015021-pol2qm74	8397	45	R	R	NNP
cord-015021-pol2qm74	8397	46	Stats	Stats	NNP
cord-015021-pol2qm74	8397	47	)	)	-RRB-
cord-015021-pol2qm74	8397	48	.	.	.
cord-015021-pol2qm74	8398	1	The	the	DT
cord-015021-pol2qm74	8398	2	Stats	Stats	NNPS
cord-015021-pol2qm74	8398	3	closest	close	JJS
cord-015021-pol2qm74	8398	4	to	to	IN
cord-015021-pol2qm74	8398	5	a	a	DT
cord-015021-pol2qm74	8398	6	new	new	JJ
cord-015021-pol2qm74	8398	7	patient	patient	NN
cord-015021-pol2qm74	8398	8	's	's	POS
cord-015021-pol2qm74	8398	9	values	value	NNS
cord-015021-pol2qm74	8398	10	allows	allow	VBZ
cord-015021-pol2qm74	8398	11	patient	patient	JJ
cord-015021-pol2qm74	8398	12	classifi0atlon	classifi0atlon	NNP
cord-015021-pol2qm74	8398	13	with	with	IN
cord-015021-pol2qm74	8398	14	regard	regard	NN
cord-015021-pol2qm74	8398	15	to	to	IN
cord-015021-pol2qm74	8398	16	his	-PRON-	PRP$
cord-015021-pol2qm74	8398	17	previous	previous	JJ
cord-015021-pol2qm74	8398	18	physiologic	physiologic	JJ
cord-015021-pol2qm74	8398	19	state	state	NN
cord-015021-pol2qm74	8398	20	.	.	.
cord-015021-pol2qm74	8399	1	Classifying	classify	VBG
cord-015021-pol2qm74	8399	2	observations	observation	NNS
cord-015021-pol2qm74	8399	3	f	f	NNP
cord-015021-pol2qm74	8399	4	~	~	NFP
cord-015021-pol2qm74	8399	5	om	om	IN
cord-015021-pol2qm74	8399	6	patients	patient	NNS
cord-015021-pol2qm74	8399	7	who	who	WP
cord-015021-pol2qm74	8399	8	lived	live	VBD
cord-015021-pol2qm74	8399	9	or	or	CC
cord-015021-pol2qm74	8399	10	died	die	VBD
cord-015021-pol2qm74	8399	11	who	who	WP
cord-015021-pol2qm74	8399	12	fell	fall	VBD
cord-015021-pol2qm74	8399	13	into	into	IN
cord-015021-pol2qm74	8399	14	these	these	DT
cord-015021-pol2qm74	8399	15	physiologic	physiologic	JJ
cord-015021-pol2qm74	8399	16	states	state	NNS
cord-015021-pol2qm74	8399	17	enables	enable	VBZ
cord-015021-pol2qm74	8399	18	a	a	DT
cord-015021-pol2qm74	8399	19	probability	probability	NN
cord-015021-pol2qm74	8399	20	of	of	IN
cord-015021-pol2qm74	8399	21	death	death	NN
cord-015021-pol2qm74	8399	22	(	(	-LRB-
cord-015021-pol2qm74	8399	23	P	p	NN
cord-015021-pol2qm74	8399	24	death	death	NN
cord-015021-pol2qm74	8399	25	)	)	-RRB-
cord-015021-pol2qm74	8399	26	to	to	TO
cord-015021-pol2qm74	8399	27	be	be	VB
cord-015021-pol2qm74	8399	28	obtalned	obtalne	VBN
cord-015021-pol2qm74	8399	29	.	.	.
cord-015021-pol2qm74	8400	1	Utilizing	utilize	VBG
cord-015021-pol2qm74	8400	2	this	this	DT
cord-015021-pol2qm74	8400	3	criteria	criterion	NNS
cord-015021-pol2qm74	8400	4	for	for	IN
cord-015021-pol2qm74	8400	5	the	the	DT
cord-015021-pol2qm74	8400	6	staging	staging	NN
cord-015021-pol2qm74	8400	7	of	of	IN
cord-015021-pol2qm74	8400	8	severity	severity	NN
cord-015021-pol2qm74	8400	9	in	in	IN
cord-015021-pol2qm74	8400	10	44	44	CD
cord-015021-pol2qm74	8400	11	recent	recent	JJ
cord-015021-pol2qm74	8400	12	Trauma	trauma	NN
cord-015021-pol2qm74	8400	13	patients	patient	NNS
cord-015021-pol2qm74	8400	14	the	the	DT
cord-015021-pol2qm74	8400	15	physiologic	physiologic	JJ
cord-015021-pol2qm74	8400	16	States	States	NNPS
cord-015021-pol2qm74	8400	17	accurately	accurately	RB
cord-015021-pol2qm74	8400	18	and	and	CC
cord-015021-pol2qm74	8400	19	significantly	significantly	RB
cord-015021-pol2qm74	8400	20	predicted	predict	VBD
cord-015021-pol2qm74	8400	21	the	the	DT
cord-015021-pol2qm74	8400	22	likelihood	likelihood	NN
cord-015021-pol2qm74	8400	23	that	that	IN
cord-015021-pol2qm74	8400	24	the	the	DT
cord-015021-pol2qm74	8400	25	patient	patient	NN
cord-015021-pol2qm74	8400	26	had	have	VBD
cord-015021-pol2qm74	8400	27	an	an	DT
cord-015021-pol2qm74	8400	28	increased	increase	VBN
cord-015021-pol2qm74	8400	29	circulating	circulate	VBG
cord-015021-pol2qm74	8400	30	level	level	NN
cord-015021-pol2qm74	8400	31	of	of	IN
cord-015021-pol2qm74	8400	32	the	the	DT
cord-015021-pol2qm74	8400	33	eytoklnes	eytoklnes	NNP
cord-015021-pol2qm74	8400	34	TNF	TNF	NNP
cord-015021-pol2qm74	8400	35	and	and	CC
cord-015021-pol2qm74	8400	36	IL-1	IL-1	NNP
cord-015021-pol2qm74	8400	37	.	.	.
cord-015021-pol2qm74	8401	1	The	the	DT
cord-015021-pol2qm74	8401	2	probability	probability	NN
cord-015021-pol2qm74	8401	3	of	of	IN
cord-015021-pol2qm74	8401	4	death	death	NN
cord-015021-pol2qm74	8401	5	(	(	-LRB-
cord-015021-pol2qm74	8401	6	P	p	NN
cord-015021-pol2qm74	8401	7	death	death	NN
cord-015021-pol2qm74	8401	8	)	)	-RRB-
cord-015021-pol2qm74	8401	9	as	as	RB
cord-015021-pol2qm74	8401	10	well	well	RB
cord-015021-pol2qm74	8401	11	as	as	IN
cord-015021-pol2qm74	8401	12	the	the	DT
cord-015021-pol2qm74	8401	13	cytoklne	cytoklne	JJ
cord-015021-pol2qm74	8401	14	levels	level	NNS
cord-015021-pol2qm74	8401	15	appear	appear	VBP
cord-015021-pol2qm74	8401	16	to	to	TO
cord-015021-pol2qm74	8401	17	be	be	VB
cord-015021-pol2qm74	8401	18	a	a	DT
cord-015021-pol2qm74	8401	19	function	function	NN
cord-015021-pol2qm74	8401	20	of	of	IN
cord-015021-pol2qm74	8401	21	the	the	DT
cord-015021-pol2qm74	8401	22	physiologic	physiologic	JJ
cord-015021-pol2qm74	8401	23	B	B	NNP
cord-015021-pol2qm74	8401	24	State	State	NNP
cord-015021-pol2qm74	8401	25	with	with	IN
cord-015021-pol2qm74	8401	26	the	the	DT
cord-015021-pol2qm74	8401	27	highest	high	JJS
cord-015021-pol2qm74	8401	28	levels	level	NNS
cord-015021-pol2qm74	8401	29	being	be	VBG
cord-015021-pol2qm74	8401	30	seen	see	VBN
cord-015021-pol2qm74	8401	31	in	in	IN
cord-015021-pol2qm74	8401	32	the	the	DT
cord-015021-pol2qm74	8401	33	B	B	NNP
cord-015021-pol2qm74	8401	34	State	State	NNP
cord-015021-pol2qm74	8401	35	of	of	IN
cord-015021-pol2qm74	8401	36	metabolic	metabolic	JJ
cord-015021-pol2qm74	8401	37	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8401	38	and	and	CC
cord-015021-pol2qm74	8401	39	the	the	DT
cord-015021-pol2qm74	8401	40	C~	C~	NNP
cord-015021-pol2qm74	8401	41	State	State	NNP
cord-015021-pol2qm74	8401	42	of	of	IN
cord-015021-pol2qm74	8401	43	oombined	oombine	VBN
cord-015021-pol2qm74	8401	44	respiratory	respiratory	JJ
cord-015021-pol2qm74	8401	45	and	and	CC
cord-015021-pol2qm74	8401	46	metabolic	metabolic	JJ
cord-015021-pol2qm74	8401	47	insqffioienoy	insqffioienoy	NN
cord-015021-pol2qm74	8401	48	characteristic	characteristic	NN
cord-015021-pol2qm74	8401	49	of	of	IN
cord-015021-pol2qm74	8401	50	septlc	septlc	NN
cord-015021-pol2qm74	8401	51	ARDS	ARDS	NNP
cord-015021-pol2qm74	8401	52	.	.	.
cord-015021-pol2qm74	8402	1	The	the	DT
cord-015021-pol2qm74	8402	2	increase	increase	NN
cord-015021-pol2qm74	8402	3	in	in	IN
cord-015021-pol2qm74	8402	4	the	the	DT
cord-015021-pol2qm74	8402	5	magnltude	magnltude	NN
cord-015021-pol2qm74	8402	6	of	of	IN
cord-015021-pol2qm74	8402	7	metabolic	metabolic	JJ
cord-015021-pol2qm74	8402	8	abnormalities	abnormality	NNS
cord-015021-pol2qm74	8402	9	associated	associate	VBN
cord-015021-pol2qm74	8402	10	with	with	IN
cord-015021-pol2qm74	8402	11	the	the	DT
cord-015021-pol2qm74	8402	12	transition	transition	NN
cord-015021-pol2qm74	8402	13	from	from	IN
cord-015021-pol2qm74	8402	14	non	non	JJ
cord-015021-pol2qm74	8402	15	-	-	NN
cord-015021-pol2qm74	8402	16	sepsls	sepsls	JJ
cord-015021-pol2qm74	8402	17	to	to	TO
cord-015021-pol2qm74	8402	18	septic	septic	VB
cord-015021-pol2qm74	8402	19	A	a	DT
cord-015021-pol2qm74	8402	20	,	,	,
cord-015021-pol2qm74	8402	21	septic	septic	JJ
cord-015021-pol2qm74	8402	22	B	b	NN
cord-015021-pol2qm74	8402	23	,	,	,
cord-015021-pol2qm74	8402	24	or	or	CC
cord-015021-pol2qm74	8402	25	septic	septic	JJ
cord-015021-pol2qm74	8402	26	C	c	NN
cord-015021-pol2qm74	8402	27	z	z	NNP
cord-015021-pol2qm74	8402	28	States	States	NNP
cord-015021-pol2qm74	8402	29	WaS	be	VBD
cord-015021-pol2qm74	8402	30	associated	associate	VBN
cord-015021-pol2qm74	8402	31	with	with	IN
cord-015021-pol2qm74	8402	32	an	an	DT
cord-015021-pol2qm74	8402	33	increasing	increase	VBG
cord-015021-pol2qm74	8402	34	probability	probability	NN
cord-015021-pol2qm74	8402	35	of	of	IN
cord-015021-pol2qm74	8402	36	death	death	NN
cord-015021-pol2qm74	8402	37	(	(	-LRB-
cord-015021-pol2qm74	8402	38	P	p	NN
cord-015021-pol2qm74	8402	39	denth)(mean	denth)(mean	NNP
cord-015021-pol2qm74	8402	40	A	a	DT
cord-015021-pol2qm74	8402	41	state	state	NN
cord-015021-pol2qm74	8402	42	=	=	SYM
cord-015021-pol2qm74	8402	43	.28	.28	NN
cord-015021-pol2qm74	8402	44	,	,	,
cord-015021-pol2qm74	8402	45	mean	mean	JJ
cord-015021-pol2qm74	8402	46	B	B	NNP
cord-015021-pol2qm74	8402	47	State	state	NN
cord-015021-pol2qm74	8402	48	=	=	NFP
cord-015021-pol2qm74	8403	1	.57	.57	.
cord-015021-pol2qm74	8404	1	,	,	,
cord-015021-pol2qm74	8404	2	mean	mean	VB
cord-015021-pol2qm74	8404	3	~	~	NFP
cord-015021-pol2qm74	8404	4	State	state	NN
cord-015021-pol2qm74	8404	5	=	=	SYM
cord-015021-pol2qm74	8404	6	.61	.61	CD
cord-015021-pol2qm74	8404	7	)	)	-RRB-
cord-015021-pol2qm74	8404	8	.	.	.
cord-015021-pol2qm74	8405	1	The	the	DT
cord-015021-pol2qm74	8405	2	accuraay	accuraay	NN
cord-015021-pol2qm74	8405	3	of	of	IN
cord-015021-pol2qm74	8405	4	this	this	DT
cord-015021-pol2qm74	8405	5	estimate	estimate	NN
cord-015021-pol2qm74	8405	6	was	be	VBD
cord-015021-pol2qm74	8405	7	prospectively	prospectively	RB
cord-015021-pol2qm74	8405	8	analyzed	analyze	VBN
cord-015021-pol2qm74	8405	9	in	in	IN
cord-015021-pol2qm74	8405	10	this	this	DT
cord-015021-pol2qm74	8405	11	group	group	NN
cord-015021-pol2qm74	8405	12	of	of	IN
cord-015021-pol2qm74	8405	13	44	44	CD
cord-015021-pol2qm74	8405	14	m	m	NN
cord-015021-pol2qm74	8405	15	~	~	NFP
cord-015021-pol2qm74	8405	16	Itlple	Itlple	NNP
cord-015021-pol2qm74	8405	17	patients	patient	NNS
cord-015021-pol2qm74	8405	18	of	of	IN
cord-015021-pol2qm74	8405	19	whom	whom	WP
cord-015021-pol2qm74	8405	20	72	72	CD
cord-015021-pol2qm74	8405	21	%	%	NN
cord-015021-pol2qm74	8405	22	had	have	VBD
cord-015021-pol2qm74	8405	23	sepsis	sepsis	NN
cord-015021-pol2qm74	8405	24	and	and	CC
cord-015021-pol2qm74	8405	25	36	36	CD
cord-015021-pol2qm74	8405	26	%	%	NN
cord-015021-pol2qm74	8405	27	had	have	VBD
cord-015021-pol2qm74	8405	28	ssptlo	ssptlo	FW
cord-015021-pol2qm74	8405	29	ARDS	ARDS	NNP
cord-015021-pol2qm74	8405	30	.	.	.
cord-015021-pol2qm74	8406	1	The	the	DT
cord-015021-pol2qm74	8406	2	22	22	CD
cord-015021-pol2qm74	8406	3	survivors	survivor	NNS
cord-015021-pol2qm74	8406	4	had	have	VBD
cord-015021-pol2qm74	8406	5	a	a	DT
cord-015021-pol2qm74	8406	6	mean	mean	NN
cord-015021-pol2qm74	8406	7	P	p	NN
cord-015021-pol2qm74	8406	8	death	death	NN
cord-015021-pol2qm74	8406	9	of	of	IN
cord-015021-pol2qm74	8406	10	0.39	0.39	CD
cord-015021-pol2qm74	8406	11	and	and	CC
cord-015021-pol2qm74	8406	12	the	the	DT
cord-015021-pol2qm74	8406	13	22	22	CD
cord-015021-pol2qm74	8406	14	deaths	death	NNS
cord-015021-pol2qm74	8406	15	had	have	VBD
cord-015021-pol2qm74	8406	16	a	a	DT
cord-015021-pol2qm74	8406	17	mean	mean	NN
cord-015021-pol2qm74	8406	18	P	p	NN
cord-015021-pol2qm74	8406	19	death	death	NN
cord-015021-pol2qm74	8406	20	of	of	IN
cord-015021-pol2qm74	8406	21	0.63	0.63	CD
cord-015021-pol2qm74	8406	22	.	.	.
cord-015021-pol2qm74	8407	1	The	the	DT
cord-015021-pol2qm74	8407	2	severity	severity	NN
cord-015021-pol2qm74	8407	3	of	of	IN
cord-015021-pol2qm74	8407	4	post	post	JJ
cord-015021-pol2qm74	8407	5	-	-	JJ
cord-015021-pol2qm74	8407	6	Trauma	trauma	JJ
cord-015021-pol2qm74	8407	7	sepsis	sepsis	NN
cord-015021-pol2qm74	8407	8	can	can	MD
cord-015021-pol2qm74	8407	9	be	be	VB
cord-015021-pol2qm74	8407	10	quantified	quantify	VBN
cord-015021-pol2qm74	8407	11	by	by	IN
cord-015021-pol2qm74	8407	12	probability	probability	NN
cord-015021-pol2qm74	8407	13	analysis	analysis	NN
cord-015021-pol2qm74	8407	14	and	and	CC
cord-015021-pol2qm74	8407	15	stra	stra	NNP
cord-015021-pol2qm74	8407	16	~	~	NFP
cord-015021-pol2qm74	8407	17	Ifie~	Ifie~	VBN
cord-015021-pol2qm74	8407	18	by	by	IN
cord-015021-pol2qm74	8407	19	physiologic	physiologic	JJ
cord-015021-pol2qm74	8407	20	State	state	NN
cord-015021-pol2qm74	8407	21	.	.	.
cord-015021-pol2qm74	8408	1	Serologic	Serologic	NNP
cord-015021-pol2qm74	8408	2	tests	test	NNS
cord-015021-pol2qm74	8408	3	have	have	VBP
cord-015021-pol2qm74	8408	4	not	not	RB
cord-015021-pol2qm74	8408	5	been	be	VBN
cord-015021-pol2qm74	8408	6	extensively	extensively	RB
cord-015021-pol2qm74	8408	7	tes'~ed	tes'~e	VBN
cord-015021-pol2qm74	8408	8	in	in	IN
cord-015021-pol2qm74	8408	9	surgical	surgical	JJ
cord-015021-pol2qm74	8408	10	patients	patient	NNS
cord-015021-pol2qm74	8408	11	but	but	CC
cord-015021-pol2qm74	8408	12	seem	seem	VBP
cord-015021-pol2qm74	8408	13	to	to	TO
cord-015021-pol2qm74	8408	14	be	be	VB
cord-015021-pol2qm74	8408	15	of	of	IN
cord-015021-pol2qm74	8408	16	limited	limited	JJ
cord-015021-pol2qm74	8408	17	value	value	NN
cord-015021-pol2qm74	8408	18	.	.	.
cord-015021-pol2qm74	8409	1	We	-PRON-	PRP
cord-015021-pol2qm74	8409	2	use	use	VBP
cord-015021-pol2qm74	8409	3	nystatin	nystatin	NNS
cord-015021-pol2qm74	8409	4	as	as	IN
cord-015021-pol2qm74	8409	5	the	the	DT
cord-015021-pol2qm74	8409	6	main	main	JJ
cord-015021-pol2qm74	8409	7	form	form	NN
cord-015021-pol2qm74	8409	8	of	of	IN
cord-015021-pol2qm74	8409	9	chemoprophyhxis	chemoprophyhxis	NN
cord-015021-pol2qm74	8409	10	.	.	.
cord-015021-pol2qm74	8410	1	Patients	patient	NNS
cord-015021-pol2qm74	8410	2	"	"	''
cord-015021-pol2qm74	8411	1	~'ith	~'ith	NFP
cord-015021-pol2qm74	8411	2	signs	sign	NNS
cord-015021-pol2qm74	8411	3	of	of	IN
cord-015021-pol2qm74	8411	4	infection	infection	NN
cord-015021-pol2qm74	8411	5	who	who	WP
cord-015021-pol2qm74	8411	6	do	do	VBP
cord-015021-pol2qm74	8411	7	not	not	RB
cord-015021-pol2qm74	8411	8	rapidly	rapidly	RB
cord-015021-pol2qm74	8411	9	improve	improve	VB
cord-015021-pol2qm74	8411	10	with	with	IN
cord-015021-pol2qm74	8411	11	antibacterial	antibacterial	JJ
cord-015021-pol2qm74	8411	12	therapy	therapy	NN
cord-015021-pol2qm74	8411	13	are	be	VBP
cord-015021-pol2qm74	8411	14	candidates	candidate	NNS
cord-015021-pol2qm74	8411	15	for	for	IN
cord-015021-pol2qm74	8411	16	anti	anti	JJ
cord-015021-pol2qm74	8411	17	-	-	JJ
cord-015021-pol2qm74	8411	18	funsal	funsal	JJ
cord-015021-pol2qm74	8411	19	therapy	therapy	NN
cord-015021-pol2qm74	8411	20	,	,	,
cord-015021-pol2qm74	8411	21	Amphoteradn	Amphoteradn	NNP
cord-015021-pol2qm74	8411	22	B	B	NNP
cord-015021-pol2qm74	8411	23	remains	remain	VBZ
cord-015021-pol2qm74	8411	24	the	the	DT
cord-015021-pol2qm74	8411	25	first	first	JJ
cord-015021-pol2qm74	8411	26	llne	llne	NN
cord-015021-pol2qm74	8411	27	of	of	IN
cord-015021-pol2qm74	8411	28	therapy	therapy	NN
cord-015021-pol2qm74	8411	29	although	although	IN
cord-015021-pol2qm74	8411	30	combination	combination	NN
cord-015021-pol2qm74	8411	31	therapy	therapy	NN
cord-015021-pol2qm74	8411	32	'	'	POS
cord-015021-pol2qm74	8411	33	~'ith	~'ith	CD
cord-015021-pol2qm74	8411	34	flueonazole	flueonazole	NNP
cord-015021-pol2qm74	8411	35	is	be	VBZ
cord-015021-pol2qm74	8411	36	use;l	use;l	NNP
cord-015021-pol2qm74	8411	37	with	with	IN
cord-015021-pol2qm74	8411	38	increasing	increase	VBG
cord-015021-pol2qm74	8411	39	freque~;c	freque~;c	NNS
cord-015021-pol2qm74	8411	40	)	)	-RRB-
cord-015021-pol2qm74	8411	41	'	'	''
cord-015021-pol2qm74	8411	42	,	,	,
cord-015021-pol2qm74	8411	43	The	the	DT
cord-015021-pol2qm74	8411	44	recovery	recovery	NN
cord-015021-pol2qm74	8411	45	of	of	IN
cord-015021-pol2qm74	8411	46	C	C	NNP
cord-015021-pol2qm74	8411	47	~	~	NFP
cord-015021-pol2qm74	8411	48	dida	dida	NNP
cord-015021-pol2qm74	8411	49	from	from	IN
cord-015021-pol2qm74	8411	50	an	an	DT
cord-015021-pol2qm74	8411	51	antra	antra	JJ
cord-015021-pol2qm74	8411	52	-	-	HYPH
cord-015021-pol2qm74	8411	53	abdominal	abdominal	JJ
cord-015021-pol2qm74	8411	54	site	site	NN
cord-015021-pol2qm74	8411	55	represents	represent	VBZ
cord-015021-pol2qm74	8411	56	a	a	DT
cord-015021-pol2qm74	8411	57	challenging	challenging	JJ
cord-015021-pol2qm74	8411	58	problem	problem	NN
cord-015021-pol2qm74	8411	59	,	,	,
cord-015021-pol2qm74	8411	60	Anti	Anti	NNP
cord-015021-pol2qm74	8411	61	~	~	NNP
cord-015021-pol2qm74	8411	62	ngal	ngal	JJ
cord-015021-pol2qm74	8411	63	therapy	therapy	NN
cord-015021-pol2qm74	8411	64	in	in	IN
cord-015021-pol2qm74	8411	65	such	such	JJ
cord-015021-pol2qm74	8411	66	patients	patient	NNS
cord-015021-pol2qm74	8411	67	depends	depend	VBZ
cord-015021-pol2qm74	8411	68	on	on	IN
cord-015021-pol2qm74	8411	69	the	the	DT
cord-015021-pol2qm74	8411	70	underlying	underlie	VBG
cord-015021-pol2qm74	8411	71	disease	disease	NN
cord-015021-pol2qm74	8411	72	,	,	,
cord-015021-pol2qm74	8411	73	the	the	DT
cord-015021-pol2qm74	8411	74	nature	nature	NN
cord-015021-pol2qm74	8411	75	of	of	IN
cord-015021-pol2qm74	8411	76	the	the	DT
cord-015021-pol2qm74	8411	77	infected	infected	JJ
cord-015021-pol2qm74	8411	78	material	material	NN
cord-015021-pol2qm74	8411	79	and	and	CC
cord-015021-pol2qm74	8411	80	overall	overall	JJ
cord-015021-pol2qm74	8411	81	patient	patient	JJ
cord-015021-pol2qm74	8411	82	risk	risk	NN
cord-015021-pol2qm74	8411	83	.	.	.
cord-015021-pol2qm74	8412	1	Role	role	NN
cord-015021-pol2qm74	8412	2	of	of	IN
cord-015021-pol2qm74	8412	3	neural	neural	JJ
cord-015021-pol2qm74	8412	4	stimuli	stimulus	NNS
cord-015021-pol2qm74	8412	5	and	and	CC
cord-015021-pol2qm74	8412	6	pain	pain	NN
cord-015021-pol2qm74	8412	7	Principles	Principles	NNPS
cord-015021-pol2qm74	8412	8	and	and	CC
cord-015021-pol2qm74	8412	9	Practice	practice	NN
cord-015021-pol2qm74	8412	10	of	of	IN
cord-015021-pol2qm74	8412	11	Anesthesiology	Anesthesiology	NNP
cord-015021-pol2qm74	8412	12	Effect	Effect	NNP
cord-015021-pol2qm74	8412	13	of	of	IN
cord-015021-pol2qm74	8412	14	combined	combine	VBN
cord-015021-pol2qm74	8412	15	prednisolone	prednisolone	NN
cord-015021-pol2qm74	8412	16	,	,	,
cord-015021-pol2qm74	8412	17	epidural	epidural	NN
cord-015021-pol2qm74	8412	18	analgesia	analgesia	NN
cord-015021-pol2qm74	8412	19	and	and	CC
cord-015021-pol2qm74	8412	20	indomethacin	indomethacin	NN
cord-015021-pol2qm74	8412	21	on	on	IN
cord-015021-pol2qm74	8412	22	the	the	DT
cord-015021-pol2qm74	8412	23	systemic	systemic	JJ
cord-015021-pol2qm74	8412	24	response	response	NN
cord-015021-pol2qm74	8412	25	after	after	IN
cord-015021-pol2qm74	8412	26	colonic	colonic	JJ
cord-015021-pol2qm74	8412	27	surgery	surgery	NN
cord-015021-pol2qm74	8412	28	Arginine	Arginine	NNP
cord-015021-pol2qm74	8412	29	:	:	:
cord-015021-pol2qm74	8412	30	Biochemistry	Biochemistry	NNP
cord-015021-pol2qm74	8412	31	,	,	,
cord-015021-pol2qm74	8412	32	physiology	physiology	NN
cord-015021-pol2qm74	8412	33	and	and	CC
cord-015021-pol2qm74	8412	34	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8412	35	irnplications	irnplication	NNS
cord-015021-pol2qm74	8413	1	Immunosfimulatory	immunosfimulatory	JJ
cord-015021-pol2qm74	8413	2	effects	effect	NNS
cord-015021-pol2qm74	8413	3	of	of	IN
cord-015021-pol2qm74	8413	4	arginine	arginine	NN
cord-015021-pol2qm74	8413	5	in	in	IN
cord-015021-pol2qm74	8413	6	normal	normal	JJ
cord-015021-pol2qm74	8413	7	and	and	CC
cord-015021-pol2qm74	8413	8	injured	injured	JJ
cord-015021-pol2qm74	8413	9	rats	rat	NNS
cord-015021-pol2qm74	8414	1	Arginine	arginine	NN
cord-015021-pol2qm74	8414	2	stimulates	stimulate	VBZ
cord-015021-pol2qm74	8414	3	lymphocyte	lymphocyte	NN
cord-015021-pol2qm74	8414	4	immune	immune	NN
cord-015021-pol2qm74	8414	5	response	response	NN
cord-015021-pol2qm74	8414	6	in	in	IN
cord-015021-pol2qm74	8414	7	heahhy	heahhy	NNP
cord-015021-pol2qm74	8414	8	humans	human	NNS
cord-015021-pol2qm74	8414	9	Rote	Rote	NNP
cord-015021-pol2qm74	8414	10	of	of	IN
cord-015021-pol2qm74	8414	11	arginine	arginine	NN
cord-015021-pol2qm74	8414	12	in	in	IN
cord-015021-pol2qm74	8414	13	trauma	trauma	NN
cord-015021-pol2qm74	8414	14	,	,	,
cord-015021-pol2qm74	8414	15	sepsis	sepsis	NN
cord-015021-pol2qm74	8414	16	and	and	CC
cord-015021-pol2qm74	8414	17	immunity	immunity	NN
cord-015021-pol2qm74	8415	1	Arginine	arginine	NN
cord-015021-pol2qm74	8415	2	enhances	enhance	VBZ
cord-015021-pol2qm74	8415	3	wound	wind	VBN
cord-015021-pol2qm74	8415	4	healing	healing	NN
cord-015021-pol2qm74	8415	5	in	in	IN
cord-015021-pol2qm74	8415	6	humans	human	NNS
cord-015021-pol2qm74	8415	7	IF	if	IN
cord-015021-pol2qm74	8415	8	LaBrecque	LaBrecque	NNP
cord-015021-pol2qm74	8415	9	t	t	NN
cord-015021-pol2qm74	8415	10	,	,	,
cord-015021-pol2qm74	8415	11	GV	GV	NNP
cord-015021-pol2qm74	8415	12	Campion	Campion	NNP
cord-015021-pol2qm74	8415	13	t	t	NN
cord-015021-pol2qm74	8415	14	,	,	,
cord-015021-pol2qm74	8415	15	and	and	CC
cord-015021-pol2qm74	8415	16	the	the	DT
cord-015021-pol2qm74	8415	17	rhlL	rhlL	NNP
cord-015021-pol2qm74	8415	18	-	-	HYPH
cord-015021-pol2qm74	8415	19	lra	lra	NNP
cord-015021-pol2qm74	8415	20	Phase	Phase	NNP
cord-015021-pol2qm74	8415	21	I//Sepsis	I//Sepsis	NNP
cord-015021-pol2qm74	8415	22	Syndrome	Syndrome	NNP
cord-015021-pol2qm74	8415	23	Study	Study	NNP
cord-015021-pol2qm74	8415	24	Group	Group	NNP
cord-015021-pol2qm74	8416	1	The	the	DT
cord-015021-pol2qm74	8416	2	Cleveland	Cleveland	NNP
cord-015021-pol2qm74	8416	3	Clinic	Clinic	NNP
cord-015021-pol2qm74	8416	4	Foundation	Foundation	NNP
cord-015021-pol2qm74	8417	1	A	a	DT
cord-015021-pol2qm74	8417	2	murine	murine	JJ
cord-015021-pol2qm74	8417	3	-	-	HYPH
cord-015021-pol2qm74	8417	4	anti	anti	JJ
cord-015021-pol2qm74	8417	5	-	-	JJ
cord-015021-pol2qm74	8417	6	human	human	JJ
cord-015021-pol2qm74	8417	7	TNF	TNF	NNP
cord-015021-pol2qm74	8417	8	-	-	HYPH
cord-015021-pol2qm74	8417	9	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8417	10	antibody	antibody	NN
cord-015021-pol2qm74	8417	11	known	know	VBN
cord-015021-pol2qm74	8417	12	as	as	IN
cord-015021-pol2qm74	8417	13	CB6	CB6	NNP
cord-015021-pol2qm74	8417	14	was	be	VBD
cord-015021-pol2qm74	8417	15	the	the	DT
cord-015021-pol2qm74	8417	16	first	first	JJ
cord-015021-pol2qm74	8417	17	ANTI	ANTI	NNP
cord-015021-pol2qm74	8417	18	-	-	HYPH
cord-015021-pol2qm74	8417	19	tnf	tnf	NNP
cord-015021-pol2qm74	8417	20	MaB	mab	NN
cord-015021-pol2qm74	8417	21	which	which	WDT
cord-015021-pol2qm74	8417	22	was	be	VBD
cord-015021-pol2qm74	8417	23	studied	study	VBN
cord-015021-pol2qm74	8417	24	in	in	IN
cord-015021-pol2qm74	8417	25	a	a	DT
cord-015021-pol2qm74	8417	26	phase	phase	NN
cord-015021-pol2qm74	8417	27	II	ii	CD
cord-015021-pol2qm74	8417	28	multinational	multinational	JJ
cord-015021-pol2qm74	8417	29	trial	trial	NN
cord-015021-pol2qm74	8417	30	in	in	IN
cord-015021-pol2qm74	8417	31	the	the	DT
cord-015021-pol2qm74	8417	32	treatment	treatment	NN
cord-015021-pol2qm74	8417	33	of	of	IN
cord-015021-pol2qm74	8417	34	patients	patient	NNS
cord-015021-pol2qm74	8417	35	with	with	IN
cord-015021-pol2qm74	8417	36	severe	severe	JJ
cord-015021-pol2qm74	8417	37	sepsis	sepsis	NN
cord-015021-pol2qm74	8417	38	.	.	.
cord-015021-pol2qm74	8418	1	This	this	DT
cord-015021-pol2qm74	8418	2	was	be	VBD
cord-015021-pol2qm74	8418	3	an	an	DT
cord-015021-pol2qm74	8418	4	open	open	JJ
cord-015021-pol2qm74	8418	5	-	-	HYPH
cord-015021-pol2qm74	8418	6	label	label	NN
cord-015021-pol2qm74	8418	7	,	,	,
cord-015021-pol2qm74	8418	8	dose	dose	NN
cord-015021-pol2qm74	8418	9	-	-	HYPH
cord-015021-pol2qm74	8418	10	escalation	escalation	NN
cord-015021-pol2qm74	8418	11	trial	trial	NN
cord-015021-pol2qm74	8418	12	consisting	consist	VBG
cord-015021-pol2qm74	8418	13	of	of	IN
cord-015021-pol2qm74	8418	14	80	80	CD
cord-015021-pol2qm74	8418	15	patients	patient	NNS
cord-015021-pol2qm74	8418	16	who	who	WP
cord-015021-pol2qm74	8418	17	were	be	VBD
cord-015021-pol2qm74	8418	18	enrolled	enrol	VBN
cord-015021-pol2qm74	8418	19	into	into	IN
cord-015021-pol2qm74	8418	20	one	one	CD
cord-015021-pol2qm74	8418	21	of	of	IN
cord-015021-pol2qm74	8418	22	four	four	CD
cord-015021-pol2qm74	8418	23	treatment	treatment	NN
cord-015021-pol2qm74	8418	24	groups	group	NNS
cord-015021-pol2qm74	8418	25	:	:	:
cord-015021-pol2qm74	8418	26	(	(	-LRB-
cord-015021-pol2qm74	8418	27	1	1	LS
cord-015021-pol2qm74	8418	28	)	)	-RRB-
cord-015021-pol2qm74	8418	29	0.1	0.1	CD
cord-015021-pol2qm74	8418	30	mg	mg	NNP
cord-015021-pol2qm74	8418	31	/	/	SYM
cord-015021-pol2qm74	8418	32	kg	kg	NNS
cord-015021-pol2qm74	8418	33	of	of	IN
cord-015021-pol2qm74	8418	34	anti	anti	JJ
cord-015021-pol2qm74	8418	35	-	-	JJ
cord-015021-pol2qm74	8418	36	TNF	TNF	NNP
cord-015021-pol2qm74	8419	1	mAb	mAb	NNS
cord-015021-pol2qm74	8419	2	,	,	,
cord-015021-pol2qm74	8419	3	(	(	-LRB-
cord-015021-pol2qm74	8419	4	2	2	LS
cord-015021-pol2qm74	8419	5	)	)	-RRB-
cord-015021-pol2qm74	8419	6	1.0	1.0	CD
cord-015021-pol2qm74	8419	7	mg	mg	NN
cord-015021-pol2qm74	8419	8	/	/	SYM
cord-015021-pol2qm74	8419	9	kg	kg	NNP
cord-015021-pol2qm74	8419	10	,	,	,
cord-015021-pol2qm74	8419	11	(	(	-LRB-
cord-015021-pol2qm74	8419	12	3	3	CD
cord-015021-pol2qm74	8419	13	)	)	-RRB-
cord-015021-pol2qm74	8419	14	10	10	CD
cord-015021-pol2qm74	8419	15	mg	mg	NNP
cord-015021-pol2qm74	8419	16	/	/	SYM
cord-015021-pol2qm74	8419	17	kg	kg	NNS
cord-015021-pol2qm74	8419	18	or	or	CC
cord-015021-pol2qm74	8419	19	(	(	-LRB-
cord-015021-pol2qm74	8419	20	4	4	CD
cord-015021-pol2qm74	8419	21	)	)	-RRB-
cord-015021-pol2qm74	8419	22	1.0	1.0	CD
cord-015021-pol2qm74	8419	23	mg	mg	NN
cord-015021-pol2qm74	8419	24	/	/	SYM
cord-015021-pol2qm74	8419	25	kg	kg	NNP
cord-015021-pol2qm74	8419	26	at	at	IN
cord-015021-pol2qm74	8419	27	study	study	NN
cord-015021-pol2qm74	8419	28	entry	entry	NN
cord-015021-pol2qm74	8419	29	and	and	CC
cord-015021-pol2qm74	8419	30	the	the	DT
cord-015021-pol2qm74	8419	31	second	second	JJ
cord-015021-pol2qm74	8419	32	dose	dose	NN
cord-015021-pol2qm74	8419	33	24	24	CD
cord-015021-pol2qm74	8419	34	hours	hour	NNS
cord-015021-pol2qm74	8419	35	later	later	RB
cord-015021-pol2qm74	8419	36	.	.	.
cord-015021-pol2qm74	8420	1	The	the	DT
cord-015021-pol2qm74	8420	2	small	small	JJ
cord-015021-pol2qm74	8420	3	sample	sample	NN
cord-015021-pol2qm74	8420	4	size	size	NN
cord-015021-pol2qm74	8420	5	in	in	IN
cord-015021-pol2qm74	8420	6	each	each	DT
cord-015021-pol2qm74	8420	7	group	group	NN
cord-015021-pol2qm74	8420	8	(	(	-LRB-
cord-015021-pol2qm74	8420	9	n=20	n=20	NNP
cord-015021-pol2qm74	8420	10	)	)	-RRB-
cord-015021-pol2qm74	8420	11	precludes	preclude	VBZ
cord-015021-pol2qm74	8420	12	detailed	detailed	JJ
cord-015021-pol2qm74	8420	13	statistical	statistical	JJ
cord-015021-pol2qm74	8420	14	inference	inference	NN
cord-015021-pol2qm74	8420	15	in	in	IN
cord-015021-pol2qm74	8420	16	this	this	DT
cord-015021-pol2qm74	8420	17	study	study	NN
cord-015021-pol2qm74	8420	18	.	.	.
cord-015021-pol2qm74	8421	1	Nonetheless	nonetheless	RB
cord-015021-pol2qm74	8421	2	,	,	,
cord-015021-pol2qm74	8421	3	a	a	DT
cord-015021-pol2qm74	8421	4	considerable	considerable	JJ
cord-015021-pol2qm74	8421	5	amount	amount	NN
cord-015021-pol2qm74	8421	6	of	of	IN
cord-015021-pol2qm74	8421	7	useful	useful	JJ
cord-015021-pol2qm74	8421	8	information	information	NN
cord-015021-pol2qm74	8421	9	was	be	VBD
cord-015021-pol2qm74	8421	10	obtained	obtain	VBN
cord-015021-pol2qm74	8421	11	from	from	IN
cord-015021-pol2qm74	8421	12	this	this	DT
cord-015021-pol2qm74	8421	13	investigation	investigation	NN
cord-015021-pol2qm74	8421	14	.	.	.
cord-015021-pol2qm74	8422	1	irst	irst	RB
cord-015021-pol2qm74	8422	2	,	,	,
cord-015021-pol2qm74	8422	3	this	this	DT
cord-015021-pol2qm74	8422	4	study	study	NN
cord-015021-pol2qm74	8422	5	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	8422	6	the	the	DT
cord-015021-pol2qm74	8422	7	clinical	clinical	JJ
cord-015021-pol2qm74	8422	8	feasibility	feasibility	NN
cord-015021-pol2qm74	8422	9	of	of	IN
cord-015021-pol2qm74	8422	10	specific	specific	JJ
cord-015021-pol2qm74	8422	11	anticytoldne	anticytoldne	NNP
cord-015021-pol2qm74	8422	12	therapy	therapy	NN
cord-015021-pol2qm74	8422	13	in	in	IN
cord-015021-pol2qm74	8422	14	septic	septic	JJ
cord-015021-pol2qm74	8422	15	patients	patient	NNS
cord-015021-pol2qm74	8422	16	.	.	.
cord-015021-pol2qm74	8423	1	Second	second	RB
cord-015021-pol2qm74	8423	2	,	,	,
cord-015021-pol2qm74	8423	3	the	the	DT
cord-015021-pol2qm74	8423	4	measurement	measurement	NN
cord-015021-pol2qm74	8423	5	systemic	systemic	JJ
cord-015021-pol2qm74	8423	6	levels	level	NNS
cord-015021-pol2qm74	8423	7	of	of	IN
cord-015021-pol2qm74	8423	8	TNF	TNF	NNP
cord-015021-pol2qm74	8423	9	proved	prove	VBD
cord-015021-pol2qm74	8423	10	to	to	TO
cord-015021-pol2qm74	8423	11	be	be	VB
cord-015021-pol2qm74	8423	12	an	an	DT
cord-015021-pol2qm74	8423	13	elusive	elusive	JJ
cord-015021-pol2qm74	8423	14	target	target	NN
cord-015021-pol2qm74	8423	15	;	;	:
cord-015021-pol2qm74	8423	16	Interleukin-6	Interleukin-6	NNP
cord-015021-pol2qm74	8423	17	may	may	MD
cord-015021-pol2qm74	8423	18	prove	prove	VB
cord-015021-pol2qm74	8423	19	to	to	TO
cord-015021-pol2qm74	8423	20	be	be	VB
cord-015021-pol2qm74	8423	21	a	a	DT
cord-015021-pol2qm74	8423	22	more	more	RBR
cord-015021-pol2qm74	8423	23	useful	useful	JJ
cord-015021-pol2qm74	8423	24	indicator	indicator	NN
cord-015021-pol2qm74	8423	25	of	of	IN
cord-015021-pol2qm74	8423	26	cytokine	cytokine	NN
cord-015021-pol2qm74	8423	27	activation	activation	NN
cord-015021-pol2qm74	8423	28	.	.	.
cord-015021-pol2qm74	8424	1	Third	third	JJ
cord-015021-pol2qm74	8424	2	,	,	,
cord-015021-pol2qm74	8424	3	immunologic	immunologic	JJ
cord-015021-pol2qm74	8424	4	reactions	reaction	NNS
cord-015021-pol2qm74	8424	5	including	include	VBG
cord-015021-pol2qm74	8424	6	TNF	tnf	NN
cord-015021-pol2qm74	8424	7	:	:	:
cord-015021-pol2qm74	8424	8	anti	anti	JJ
cord-015021-pol2qm74	8424	9	-	-	JJ
cord-015021-pol2qm74	8424	10	TNF	tnf	JJ
cord-015021-pol2qm74	8424	11	mAb	mab	NN
cord-015021-pol2qm74	8424	12	immune	immune	JJ
cord-015021-pol2qm74	8424	13	complexes	complex	NNS
cord-015021-pol2qm74	8424	14	and	and	CC
cord-015021-pol2qm74	8424	15	human	human	JJ
cord-015021-pol2qm74	8424	16	anti	anti	JJ
cord-015021-pol2qm74	8424	17	-	-	JJ
cord-015021-pol2qm74	8424	18	routine	routine	JJ
cord-015021-pol2qm74	8424	19	antibodies	antibody	NNS
cord-015021-pol2qm74	8424	20	were	be	VBD
cord-015021-pol2qm74	8424	21	frequently	frequently	RB
cord-015021-pol2qm74	8424	22	found	find	VBN
cord-015021-pol2qm74	8424	23	in	in	IN
cord-015021-pol2qm74	8424	24	these	these	DT
cord-015021-pol2qm74	8424	25	patients	patient	NNS
cord-015021-pol2qm74	8424	26	.	.	.
cord-015021-pol2qm74	8425	1	Despite	despite	IN
cord-015021-pol2qm74	8425	2	their	-PRON-	PRP$
cord-015021-pol2qm74	8425	3	apparent	apparent	JJ
cord-015021-pol2qm74	8425	4	lack	lack	NN
cord-015021-pol2qm74	8425	5	of	of	IN
cord-015021-pol2qm74	8425	6	overt	overt	JJ
cord-015021-pol2qm74	8425	7	toxicity	toxicity	NN
cord-015021-pol2qm74	8425	8	in	in	IN
cord-015021-pol2qm74	8425	9	this	this	DT
cord-015021-pol2qm74	8425	10	study	study	NN
cord-015021-pol2qm74	8425	11	,	,	,
cord-015021-pol2qm74	8425	12	these	these	DT
cord-015021-pol2qm74	8425	13	immunologic	immunologic	JJ
cord-015021-pol2qm74	8425	14	reactions	reaction	NNS
cord-015021-pol2qm74	8425	15	may	may	MD
cord-015021-pol2qm74	8425	16	complicate	complicate	VB
cord-015021-pol2qm74	8425	17	this	this	DT
cord-015021-pol2qm74	8425	18	form	form	NN
cord-015021-pol2qm74	8425	19	of	of	IN
cord-015021-pol2qm74	8425	20	anticytokine	anticytokine	JJ
cord-015021-pol2qm74	8425	21	therapy	therapy	NN
cord-015021-pol2qm74	8425	22	.	.	.
cord-015021-pol2qm74	8426	1	Additionally	additionally	RB
cord-015021-pol2qm74	8426	2	,	,	,
cord-015021-pol2qm74	8426	3	the	the	DT
cord-015021-pol2qm74	8426	4	potential	potential	JJ
cord-015021-pol2qm74	8426	5	benefits	benefit	NNS
cord-015021-pol2qm74	8426	6	of	of	IN
cord-015021-pol2qm74	8426	7	anti	anti	JJ
cord-015021-pol2qm74	8426	8	-	-	JJ
cord-015021-pol2qm74	8426	9	TNF	tnf	JJ
cord-015021-pol2qm74	8426	10	mAb	mab	NN
cord-015021-pol2qm74	8426	11	therapy	therapy	NN
cord-015021-pol2qm74	8426	12	occur	occur	VBP
cord-015021-pol2qm74	8426	13	within	within	IN
cord-015021-pol2qm74	8426	14	the	the	DT
cord-015021-pol2qm74	8426	15	first	first	JJ
cord-015021-pol2qm74	8426	16	48	48	CD
cord-015021-pol2qm74	8426	17	hours	hour	NNS
cord-015021-pol2qm74	8426	18	of	of	IN
cord-015021-pol2qm74	8426	19	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8426	20	administration	administration	NN
cord-015021-pol2qm74	8426	21	in	in	IN
cord-015021-pol2qm74	8426	22	these	these	DT
cord-015021-pol2qm74	8426	23	septic	septic	JJ
cord-015021-pol2qm74	8426	24	patients	patient	NNS
cord-015021-pol2qm74	8426	25	.	.	.
cord-015021-pol2qm74	8427	1	Infecting	infect	VBG
cord-015021-pol2qm74	8427	2	organisms	organism	NNS
cord-015021-pol2qm74	8427	3	differ	differ	VBP
cord-015021-pol2qm74	8427	4	in	in	IN
cord-015021-pol2qm74	8427	5	their	-PRON-	PRP$
cord-015021-pol2qm74	8427	6	potential	potential	NN
cord-015021-pol2qm74	8427	7	to	to	TO
cord-015021-pol2qm74	8427	8	induce	induce	VB
cord-015021-pol2qm74	8427	9	TNF	TNF	NNP
cord-015021-pol2qm74	8427	10	in	in	IN
cord-015021-pol2qm74	8427	11	vitro	vitro	FW
cord-015021-pol2qm74	8427	12	and	and	CC
cord-015021-pol2qm74	8427	13	these	these	DT
cord-015021-pol2qm74	8427	14	differences	difference	NNS
cord-015021-pol2qm74	8427	15	correlate	correlate	VBP
cord-015021-pol2qm74	8427	16	with	with	IN
cord-015021-pol2qm74	8427	17	circulating	circulate	VBG
cord-015021-pol2qm74	8427	18	TNF	TNF	NNP
cord-015021-pol2qm74	8427	19	levels	level	NNS
cord-015021-pol2qm74	8427	20	observed	observe	VBN
cord-015021-pol2qm74	8427	21	in	in	IN
cord-015021-pol2qm74	8427	22	septic	septic	JJ
cord-015021-pol2qm74	8427	23	patients	patient	NNS
cord-015021-pol2qm74	8427	24	.	.	.
cord-015021-pol2qm74	8428	1	Rapid	rapid	JJ
cord-015021-pol2qm74	8428	2	methods	method	NNS
cord-015021-pol2qm74	8428	3	to	to	TO
cord-015021-pol2qm74	8428	4	define	define	VB
cord-015021-pol2qm74	8428	5	those	those	DT
cord-015021-pol2qm74	8428	6	patients	patient	NNS
cord-015021-pol2qm74	8428	7	most	most	RBS
cord-015021-pol2qm74	8428	8	likely	likely	JJ
cord-015021-pol2qm74	8428	9	to	to	TO
cord-015021-pol2qm74	8428	10	respond	respond	VB
cord-015021-pol2qm74	8428	11	to	to	IN
cord-015021-pol2qm74	8428	12	anticytokine	anticytokine	JJ
cord-015021-pol2qm74	8428	13	therapy	therapy	NN
cord-015021-pol2qm74	8428	14	are	be	VBP
cord-015021-pol2qm74	8428	15	needed	need	VBN
cord-015021-pol2qm74	8428	16	to	to	TO
cord-015021-pol2qm74	8428	17	determine	determine	VB
cord-015021-pol2qm74	8428	18	the	the	DT
cord-015021-pol2qm74	8428	19	ultimate	ultimate	JJ
cord-015021-pol2qm74	8428	20	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8428	21	potential	potential	NN
cord-015021-pol2qm74	8428	22	of	of	IN
cord-015021-pol2qm74	8428	23	these	these	DT
cord-015021-pol2qm74	8428	24	agents	agent	NNS
cord-015021-pol2qm74	8428	25	in	in	IN
cord-015021-pol2qm74	8428	26	clinical	clinical	JJ
cord-015021-pol2qm74	8428	27	medicine	medicine	NN
cord-015021-pol2qm74	8428	28	.	.	.
cord-015021-pol2qm74	8429	1	Wherry	Wherry	NNP
cord-015021-pol2qm74	8429	2	,	,	,
cord-015021-pol2qm74	8429	3	J.	J.	NNP
cord-015021-pol2qm74	8429	4	,	,	,
cord-015021-pol2qm74	8429	5	Abraham	Abraham	NNP
cord-015021-pol2qm74	8429	6	E.	E.	NNP
cord-015021-pol2qm74	8429	7	,	,	,
cord-015021-pol2qm74	8429	8	Wunderink	Wunderink	NNP
cord-015021-pol2qm74	8429	9	R.	R.	NNP
cord-015021-pol2qm74	8429	10	,	,	,
cord-015021-pol2qm74	8429	11	Silverman	Silverman	NNP
cord-015021-pol2qm74	8429	12	H.	H.	NNP
cord-015021-pol2qm74	8429	13	,	,	,
cord-015021-pol2qm74	8429	14	Perl	Perl	NNP
cord-015021-pol2qm74	8429	15	T.	T.	NNP
cord-015021-pol2qm74	8429	16	,	,	,
cord-015021-pol2qm74	8429	17	Nasraway	Nasraway	NNP
cord-015021-pol2qm74	8429	18	S.	S.	NNP
cord-015021-pol2qm74	8429	19	,	,	,
cord-015021-pol2qm74	8429	20	Levy	Levy	NNP
cord-015021-pol2qm74	8429	21	H.	H.	NNP
cord-015021-pol2qm74	8429	22	,	,	,
cord-015021-pol2qm74	8429	23	Bone	Bone	NNP
cord-015021-pol2qm74	8429	24	R.	R.	NNP
cord-015021-pol2qm74	8429	25	,	,	,
cord-015021-pol2qm74	8429	26	Wenzel	Wenzel	NNP
cord-015021-pol2qm74	8429	27	R.	R.	NNP
cord-015021-pol2qm74	8429	28	,	,	,
cord-015021-pol2qm74	8429	29	Balk	Balk	NNP
cord-015021-pol2qm74	8429	30	R.	R.	NNP
cord-015021-pol2qm74	8429	31	,	,	,
cord-015021-pol2qm74	8429	32	Allred	Allred	NNP
cord-015021-pol2qm74	8429	33	R.	R.	NNP
cord-015021-pol2qm74	8429	34	,	,	,
cord-015021-pol2qm74	8429	35	Pennington	Pennington	NNP
cord-015021-pol2qm74	8429	36	J.	J.	NNP
cord-015021-pol2qm74	8429	37	and	and	CC
cord-015021-pol2qm74	8429	38	the	the	DT
cord-015021-pol2qm74	8429	39	TNFa	TNFa	NNS
cord-015021-pol2qm74	8429	40	MAb	MAb	NNS
cord-015021-pol2qm74	8429	41	Sepsis	Sepsis	NNP
cord-015021-pol2qm74	8429	42	Study	Study	NNP
cord-015021-pol2qm74	8429	43	Group	Group	NNP
cord-015021-pol2qm74	8429	44	.	.	.
cord-015021-pol2qm74	8430	1	TNFa	TNFa	NNP
cord-015021-pol2qm74	8430	2	MAb	MAb	NNS
cord-015021-pol2qm74	8430	3	(	(	-LRB-
cord-015021-pol2qm74	8430	4	Bay	Bay	NNP
cord-015021-pol2qm74	8430	5	x1351	x1351	NNP
cord-015021-pol2qm74	8430	6	)	)	-RRB-
cord-015021-pol2qm74	8430	7	is	be	VBZ
cord-015021-pol2qm74	8430	8	a	a	DT
cord-015021-pol2qm74	8430	9	murine	murine	JJ
cord-015021-pol2qm74	8430	10	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8430	11	antibody	antibody	NN
cord-015021-pol2qm74	8430	12	raised	raise	VBN
cord-015021-pol2qm74	8430	13	against	against	IN
cord-015021-pol2qm74	8430	14	human	human	JJ
cord-015021-pol2qm74	8430	15	tumor	tumor	NN
cord-015021-pol2qm74	8430	16	necrosis	necrosis	NN
cord-015021-pol2qm74	8430	17	factor	factor	NN
cord-015021-pol2qm74	8430	18	.	.	.
cord-015021-pol2qm74	8431	1	TNF~	tnf~	LS
cord-015021-pol2qm74	8431	2	MAb	MAb	NNS
cord-015021-pol2qm74	8431	3	has	have	VBZ
cord-015021-pol2qm74	8431	4	been	be	VBN
cord-015021-pol2qm74	8431	5	shown	show	VBN
cord-015021-pol2qm74	8431	6	to	to	TO
cord-015021-pol2qm74	8431	7	reduce	reduce	VB
cord-015021-pol2qm74	8431	8	morbidity	morbidity	NN
cord-015021-pol2qm74	8431	9	and	and	CC
cord-015021-pol2qm74	8431	10	mortality	mortality	NN
cord-015021-pol2qm74	8431	11	in	in	IN
cord-015021-pol2qm74	8431	12	animal	animal	NN
cord-015021-pol2qm74	8431	13	models	model	NNS
cord-015021-pol2qm74	8431	14	of	of	IN
cord-015021-pol2qm74	8431	15	septic	septic	JJ
cord-015021-pol2qm74	8431	16	shock	shock	NN
cord-015021-pol2qm74	8431	17	and	and	CC
cord-015021-pol2qm74	8431	18	has	have	VBZ
cord-015021-pol2qm74	8431	19	been	be	VBN
cord-015021-pol2qm74	8431	20	safely	safely	RB
cord-015021-pol2qm74	8431	21	administered	administer	VBN
cord-015021-pol2qm74	8431	22	to	to	TO
cord-015021-pol2qm74	8431	23	septic	septic	JJ
cord-015021-pol2qm74	8431	24	and	and	CC
cord-015021-pol2qm74	8431	25	non	non	JJ
cord-015021-pol2qm74	8431	26	septic	septic	JJ
cord-015021-pol2qm74	8431	27	patients	patient	NNS
cord-015021-pol2qm74	8431	28	.	.	.
cord-015021-pol2qm74	8432	1	To	to	TO
cord-015021-pol2qm74	8432	2	evaluate	evaluate	VB
cord-015021-pol2qm74	8432	3	the	the	DT
cord-015021-pol2qm74	8432	4	efficacy	efficacy	NN
cord-015021-pol2qm74	8432	5	and	and	CC
cord-015021-pol2qm74	8432	6	safety	safety	NN
cord-015021-pol2qm74	8432	7	of	of	IN
cord-015021-pol2qm74	8432	8	TNF~	tnf~	CD
cord-015021-pol2qm74	8432	9	MAb	MAb	NNS
cord-015021-pol2qm74	8432	10	in	in	IN
cord-015021-pol2qm74	8432	11	patients	patient	NNS
cord-015021-pol2qm74	8432	12	with	with	IN
cord-015021-pol2qm74	8432	13	sepsis	sepsis	NN
cord-015021-pol2qm74	8432	14	syndrome	syndrome	NN
cord-015021-pol2qm74	8432	15	,	,	,
cord-015021-pol2qm74	8432	16	a	a	DT
cord-015021-pol2qm74	8432	17	prospective	prospective	JJ
cord-015021-pol2qm74	8432	18	,	,	,
cord-015021-pol2qm74	8432	19	multicentered	multicentered	JJ
cord-015021-pol2qm74	8432	20	,	,	,
cord-015021-pol2qm74	8432	21	double	double	JJ
cord-015021-pol2qm74	8432	22	-	-	HYPH
cord-015021-pol2qm74	8432	23	blind	blind	JJ
cord-015021-pol2qm74	8432	24	,	,	,
cord-015021-pol2qm74	8432	25	placebo	placebo	NN
cord-015021-pol2qm74	8432	26	-	-	HYPH
cord-015021-pol2qm74	8432	27	controlled	control	VBN
cord-015021-pol2qm74	8432	28	trial	trial	NN
cord-015021-pol2qm74	8432	29	was	be	VBD
cord-015021-pol2qm74	8432	30	conducted	conduct	VBN
cord-015021-pol2qm74	8432	31	in	in	IN
cord-015021-pol2qm74	8432	32	31	31	CD
cord-015021-pol2qm74	8432	33	hospitals	hospital	NNS
cord-015021-pol2qm74	8432	34	in	in	IN
cord-015021-pol2qm74	8432	35	North	North	NNP
cord-015021-pol2qm74	8432	36	America	America	NNP
cord-015021-pol2qm74	8432	37	.	.	.
cord-015021-pol2qm74	8433	1	Patients	patient	NNS
cord-015021-pol2qm74	8433	2	were	be	VBD
cord-015021-pol2qm74	8433	3	prospectively	prospectively	RB
cord-015021-pol2qm74	8433	4	stratified	stratify	VBN
cord-015021-pol2qm74	8433	5	into	into	IN
cord-015021-pol2qm74	8433	6	shock	shock	NN
cord-015021-pol2qm74	8433	7	or	or	CC
cord-015021-pol2qm74	8433	8	nonshock	nonshock	NN
cord-015021-pol2qm74	8433	9	groups	group	NNS
cord-015021-pol2qm74	8433	10	and	and	CC
cord-015021-pol2qm74	8433	11	then	then	RB
cord-015021-pol2qm74	8433	12	randomized	randomize	VBD
cord-015021-pol2qm74	8433	13	to	to	TO
cord-015021-pol2qm74	8433	14	receive	receive	VB
cord-015021-pol2qm74	8433	15	a	a	DT
cord-015021-pol2qm74	8433	16	single	single	JJ
cord-015021-pol2qm74	8433	17	intravenous	intravenous	JJ
cord-015021-pol2qm74	8433	18	infusion	infusion	NN
cord-015021-pol2qm74	8433	19	either	either	DT
cord-015021-pol2qm74	8433	20	of	of	IN
cord-015021-pol2qm74	8433	21	15	15	CD
cord-015021-pol2qm74	8433	22	mg	mg	NNP
cord-015021-pol2qm74	8433	23	/	/	SYM
cord-015021-pol2qm74	8433	24	kg	kg	NNP
cord-015021-pol2qm74	8434	1	TNF~	tnf~	LS
cord-015021-pol2qm74	8434	2	MAb	MAb	NNS
cord-015021-pol2qm74	8434	3	,	,	,
cord-015021-pol2qm74	8434	4	7.5	7.5	CD
cord-015021-pol2qm74	8434	5	mg	mg	NN
cord-015021-pol2qm74	8434	6	/	/	SYM
cord-015021-pol2qm74	8434	7	kg	kg	NNP
cord-015021-pol2qm74	8435	1	TNF~	tnf~	LS
cord-015021-pol2qm74	8435	2	MAb	MAb	NNS
cord-015021-pol2qm74	8435	3	or	or	CC
cord-015021-pol2qm74	8435	4	placebo	placebo	NN
cord-015021-pol2qm74	8435	5	(	(	-LRB-
cord-015021-pol2qm74	8435	6	0.25	0.25	CD
cord-015021-pol2qm74	8435	7	%	%	NN
cord-015021-pol2qm74	8435	8	human	human	JJ
cord-015021-pol2qm74	8435	9	albumin).Patients	albumin).patient	NNS
cord-015021-pol2qm74	8435	10	received	receive	VBD
cord-015021-pol2qm74	8435	11	standard	standard	JJ
cord-015021-pol2qm74	8435	12	aggressive	aggressive	JJ
cord-015021-pol2qm74	8435	13	medical	medical	JJ
cord-015021-pol2qm74	8435	14	/	/	SYM
cord-015021-pol2qm74	8435	15	surgical	surgical	JJ
cord-015021-pol2qm74	8435	16	care	care	NN
cord-015021-pol2qm74	8435	17	during	during	IN
cord-015021-pol2qm74	8435	18	the	the	DT
cord-015021-pol2qm74	8435	19	28	28	CD
cord-015021-pol2qm74	8435	20	day	day	NN
cord-015021-pol2qm74	8435	21	post	post	NN
cord-015021-pol2qm74	8435	22	dosing	dosing	NN
cord-015021-pol2qm74	8435	23	period	period	NN
cord-015021-pol2qm74	8435	24	.	.	.
cord-015021-pol2qm74	8436	1	The	the	DT
cord-015021-pol2qm74	8436	2	three	three	CD
cord-015021-pol2qm74	8436	3	treatment	treatment	NN
cord-015021-pol2qm74	8436	4	arms	arm	NNS
cord-015021-pol2qm74	8436	5	were	be	VBD
cord-015021-pol2qm74	8436	6	well	well	RB
cord-015021-pol2qm74	8436	7	balanced	balanced	JJ
cord-015021-pol2qm74	8436	8	with	with	IN
cord-015021-pol2qm74	8436	9	respect	respect	NN
cord-015021-pol2qm74	8436	10	to	to	IN
cord-015021-pol2qm74	8436	11	demographics	demographic	NNS
cord-015021-pol2qm74	8436	12	,	,	,
cord-015021-pol2qm74	8436	13	APACHE	APACHE	NNP
cord-015021-pol2qm74	8436	14	II	II	NNP
cord-015021-pol2qm74	8436	15	score	score	NN
cord-015021-pol2qm74	8436	16	and	and	CC
cord-015021-pol2qm74	8436	17	other	other	JJ
cord-015021-pol2qm74	8436	18	parameters	parameter	NNS
cord-015021-pol2qm74	8436	19	.	.	.
cord-015021-pol2qm74	8437	1	For	for	IN
cord-015021-pol2qm74	8437	2	all	all	DT
cord-015021-pol2qm74	8437	3	infused	infuse	VBN
cord-015021-pol2qm74	8437	4	sepsis	sepsis	NN
cord-015021-pol2qm74	8437	5	syndrome	syndrome	NN
cord-015021-pol2qm74	8437	6	patients	patient	NNS
cord-015021-pol2qm74	8437	7	,	,	,
cord-015021-pol2qm74	8437	8	those	those	DT
cord-015021-pol2qm74	8437	9	who	who	WP
cord-015021-pol2qm74	8437	10	received	receive	VBD
cord-015021-pol2qm74	8437	11	TNF~	tnf~	CD
cord-015021-pol2qm74	8437	12	MAb	MAb	NNS
cord-015021-pol2qm74	8437	13	had	have	VBD
cord-015021-pol2qm74	8437	14	slightly	slightly	RB
cord-015021-pol2qm74	8437	15	reduced	reduce	VBN
cord-015021-pol2qm74	8437	16	28	28	CD
cord-015021-pol2qm74	8437	17	day	day	NN
cord-015021-pol2qm74	8437	18	all	all	DT
cord-015021-pol2qm74	8437	19	cause	cause	VBP
cord-015021-pol2qm74	8437	20	mortality	mortality	NN
cord-015021-pol2qm74	8437	21	compared	compare	VBN
cord-015021-pol2qm74	8437	22	to	to	IN
cord-015021-pol2qm74	8437	23	placebo	placebo	NN
cord-015021-pol2qm74	8437	24	.	.	.
cord-015021-pol2qm74	8438	1	Among	among	IN
cord-015021-pol2qm74	8438	2	shock	shock	NN
cord-015021-pol2qm74	8438	3	patients	patient	NNS
cord-015021-pol2qm74	8438	4	there	there	EX
cord-015021-pol2qm74	8438	5	was	be	VBD
cord-015021-pol2qm74	8438	6	a	a	DT
cord-015021-pol2qm74	8438	7	more	more	RBR
cord-015021-pol2qm74	8438	8	pronounced	pronounced	JJ
cord-015021-pol2qm74	8438	9	trend	trend	NN
cord-015021-pol2qm74	8438	10	towards	towards	IN
cord-015021-pol2qm74	8438	11	efficacy	efficacy	NN
cord-015021-pol2qm74	8438	12	at	at	IN
cord-015021-pol2qm74	8438	13	day	day	NN
cord-015021-pol2qm74	8438	14	28	28	CD
cord-015021-pol2qm74	8438	15	post	post	NN
cord-015021-pol2qm74	8438	16	dosing	dosing	NN
cord-015021-pol2qm74	8438	17	with	with	IN
cord-015021-pol2qm74	8438	18	lower	low	JJR
cord-015021-pol2qm74	8438	19	mortality	mortality	NN
cord-015021-pol2qm74	8438	20	rates	rate	NNS
cord-015021-pol2qm74	8438	21	in	in	IN
cord-015021-pol2qm74	8438	22	both	both	DT
cord-015021-pol2qm74	8438	23	active	active	JJ
cord-015021-pol2qm74	8438	24	treatment	treatment	NN
cord-015021-pol2qm74	8438	25	arms	arm	NNS
cord-015021-pol2qm74	8438	26	.	.	.
cord-015021-pol2qm74	8439	1	Among	among	IN
cord-015021-pol2qm74	8439	2	nonshock	nonshock	NN
cord-015021-pol2qm74	8439	3	patients	patient	NNS
cord-015021-pol2qm74	8439	4	TN~	TN~	NNP
cord-015021-pol2qm74	8439	5	MAb	MAb	NNS
cord-015021-pol2qm74	8439	6	did	do	VBD
cord-015021-pol2qm74	8439	7	not	not	RB
cord-015021-pol2qm74	8439	8	appear	appear	VB
cord-015021-pol2qm74	8439	9	beneficial	beneficial	JJ
cord-015021-pol2qm74	8439	10	.	.	.
cord-015021-pol2qm74	8440	1	The	the	DT
cord-015021-pol2qm74	8440	2	initial	initial	JJ
cord-015021-pol2qm74	8440	3	clinical	clinical	JJ
cord-015021-pol2qm74	8440	4	experience	experience	NN
cord-015021-pol2qm74	8440	5	with	with	IN
cord-015021-pol2qm74	8440	6	a	a	DT
cord-015021-pol2qm74	8440	7	chimeric	chimeric	JJ
cord-015021-pol2qm74	8440	8	anti	anti	JJ
cord-015021-pol2qm74	8440	9	-	-	JJ
cord-015021-pol2qm74	8440	10	TNF	tnf	JJ
cord-015021-pol2qm74	8440	11	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8440	12	antibody	antibody	NN
cord-015021-pol2qm74	8440	13	,	,	,
cord-015021-pol2qm74	8440	14	cA2	cA2	NNP
cord-015021-pol2qm74	8440	15	,	,	,
cord-015021-pol2qm74	8440	16	was	be	VBD
cord-015021-pol2qm74	8440	17	undertaken	undertake	VBN
cord-015021-pol2qm74	8440	18	in	in	IN
cord-015021-pol2qm74	8440	19	septic	septic	JJ
cord-015021-pol2qm74	8440	20	patients	patient	NNS
cord-015021-pol2qm74	8440	21	.	.	.
cord-015021-pol2qm74	8441	1	The	the	DT
cord-015021-pol2qm74	8441	2	objectives	objective	NNS
cord-015021-pol2qm74	8441	3	of	of	IN
cord-015021-pol2qm74	8441	4	the	the	DT
cord-015021-pol2qm74	8441	5	study	study	NN
cord-015021-pol2qm74	8441	6	were	be	VBD
cord-015021-pol2qm74	8441	7	to	to	TO
cord-015021-pol2qm74	8441	8	determine	determine	VB
cord-015021-pol2qm74	8441	9	the	the	DT
cord-015021-pol2qm74	8441	10	safety	safety	NN
cord-015021-pol2qm74	8441	11	,	,	,
cord-015021-pol2qm74	8441	12	pharmacokinetics	pharmacokinetic	NNS
cord-015021-pol2qm74	8441	13	and	and	CC
cord-015021-pol2qm74	8441	14	effects	effect	NNS
cord-015021-pol2qm74	8441	15	on	on	IN
cord-015021-pol2qm74	8441	16	cytokine	cytokine	NN
cord-015021-pol2qm74	8441	17	levels	level	NNS
cord-015021-pol2qm74	8441	18	of	of	IN
cord-015021-pol2qm74	8441	19	cA2	ca2	NN
cord-015021-pol2qm74	8441	20	.	.	.
cord-015021-pol2qm74	8442	1	as	as	IN
cord-015021-pol2qm74	8442	2	a	a	DT
cord-015021-pol2qm74	8442	3	single	single	JJ
cord-015021-pol2qm74	8442	4	infusion	infusion	NN
cord-015021-pol2qm74	8442	5	or	or	CC
cord-015021-pol2qm74	8442	6	in	in	IN
cord-015021-pol2qm74	8442	7	combination	combination	NN
cord-015021-pol2qm74	8442	8	with	with	IN
cord-015021-pol2qm74	8442	9	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	8442	10	in	in	IN
cord-015021-pol2qm74	8442	11	septic	septic	JJ
cord-015021-pol2qm74	8442	12	patients	patient	NNS
cord-015021-pol2qm74	8442	13	.	.	.
cord-015021-pol2qm74	8443	1	The	the	DT
cord-015021-pol2qm74	8443	2	study	study	NN
cord-015021-pol2qm74	8443	3	was	be	VBD
cord-015021-pol2qm74	8443	4	conducted	conduct	VBN
cord-015021-pol2qm74	8443	5	with	with	IN
cord-015021-pol2qm74	8443	6	the	the	DT
cord-015021-pol2qm74	8443	7	intent	intent	NN
cord-015021-pol2qm74	8443	8	to	to	TO
cord-015021-pol2qm74	8443	9	progress	progress	VB
cord-015021-pol2qm74	8443	10	to	to	IN
cord-015021-pol2qm74	8443	11	an	an	DT
cord-015021-pol2qm74	8443	12	efficacy	efficacy	NN
cord-015021-pol2qm74	8443	13	trial	trial	NN
cord-015021-pol2qm74	8443	14	based	base	VBN
cord-015021-pol2qm74	8443	15	on	on	IN
cord-015021-pol2qm74	8443	16	the	the	DT
cord-015021-pol2qm74	8443	17	information	information	NN
cord-015021-pol2qm74	8443	18	collected	collect	VBN
cord-015021-pol2qm74	8443	19	.	.	.
cord-015021-pol2qm74	8444	1	The	the	DT
cord-015021-pol2qm74	8444	2	trial	trial	NN
cord-015021-pol2qm74	8444	3	was	be	VBD
cord-015021-pol2qm74	8444	4	conducted	conduct	VBN
cord-015021-pol2qm74	8444	5	in	in	IN
cord-015021-pol2qm74	8444	6	three	three	CD
cord-015021-pol2qm74	8444	7	stages	stage	NNS
cord-015021-pol2qm74	8444	8	.	.	.
cord-015021-pol2qm74	8445	1	Stage	stage	NN
cord-015021-pol2qm74	8445	2	1	1	CD
cord-015021-pol2qm74	8445	3	was	be	VBD
cord-015021-pol2qm74	8445	4	an	an	DT
cord-015021-pol2qm74	8445	5	open	open	JJ
cord-015021-pol2qm74	8445	6	label	label	NN
cord-015021-pol2qm74	8445	7	trial	trial	NN
cord-015021-pol2qm74	8445	8	in	in	IN
cord-015021-pol2qm74	8445	9	which	which	WDT
cord-015021-pol2qm74	8445	10	4	4	CD
cord-015021-pol2qm74	8445	11	groups	group	NNS
cord-015021-pol2qm74	8445	12	of	of	IN
cord-015021-pol2qm74	8445	13	5	5	CD
cord-015021-pol2qm74	8445	14	patients	patient	NNS
cord-015021-pol2qm74	8445	15	each	each	DT
cord-015021-pol2qm74	8445	16	with	with	IN
cord-015021-pol2qm74	8445	17	the	the	DT
cord-015021-pol2qm74	8445	18	clinical	clinical	JJ
cord-015021-pol2qm74	8445	19	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8445	20	of	of	IN
cord-015021-pol2qm74	8445	21	sepsis	sepsis	NN
cord-015021-pol2qm74	8445	22	received	receive	VBD
cord-015021-pol2qm74	8445	23	ascending	ascend	VBG
cord-015021-pol2qm74	8445	24	doses	dose	NNS
cord-015021-pol2qm74	8445	25	of	of	IN
cord-015021-pol2qm74	8445	26	cA2	ca2	NN
cord-015021-pol2qm74	8445	27	(	(	-LRB-
cord-015021-pol2qm74	8445	28	0.1	0.1	CD
cord-015021-pol2qm74	8445	29	,	,	,
cord-015021-pol2qm74	8445	30	1	1	CD
cord-015021-pol2qm74	8445	31	,	,	,
cord-015021-pol2qm74	8445	32	5	5	CD
cord-015021-pol2qm74	8445	33	,	,	,
cord-015021-pol2qm74	8445	34	10	10	CD
cord-015021-pol2qm74	8445	35	mg	mg	NNP
cord-015021-pol2qm74	8445	36	/	/	SYM
cord-015021-pol2qm74	8445	37	kg	kg	NNP
cord-015021-pol2qm74	8445	38	)	)	-RRB-
cord-015021-pol2qm74	8445	39	.	.	.
cord-015021-pol2qm74	8446	1	Stage	stage	NN
cord-015021-pol2qm74	8446	2	2	2	CD
cord-015021-pol2qm74	8446	3	was	be	VBD
cord-015021-pol2qm74	8446	4	a	a	DT
cord-015021-pol2qm74	8446	5	randomized	randomized	JJ
cord-015021-pol2qm74	8446	6	,	,	,
cord-015021-pol2qm74	8446	7	double	double	JJ
cord-015021-pol2qm74	8446	8	blind	blind	JJ
cord-015021-pol2qm74	8446	9	study	study	NN
cord-015021-pol2qm74	8446	10	in	in	IN
cord-015021-pol2qm74	8446	11	which	which	WDT
cord-015021-pol2qm74	8446	12	patients	patient	NNS
cord-015021-pol2qm74	8446	13	received	receive	VBD
cord-015021-pol2qm74	8446	14	a	a	DT
cord-015021-pol2qm74	8446	15	single	single	JJ
cord-015021-pol2qm74	8446	16	dose	dose	NN
cord-015021-pol2qm74	8446	17	of	of	IN
cord-015021-pol2qm74	8446	18	HA-1A	HA-1A	NNP
cord-015021-pol2qm74	8446	19	(	(	-LRB-
cord-015021-pol2qm74	8446	20	100	100	CD
cord-015021-pol2qm74	8446	21	mg	mg	NNS
cord-015021-pol2qm74	8446	22	)	)	-RRB-
cord-015021-pol2qm74	8446	23	and	and	CC
cord-015021-pol2qm74	8446	24	placebo	placebo	NN
cord-015021-pol2qm74	8446	25	or	or	CC
cord-015021-pol2qm74	8446	26	one	one	CD
cord-015021-pol2qm74	8446	27	of	of	IN
cord-015021-pol2qm74	8446	28	3	3	CD
cord-015021-pol2qm74	8446	29	doses	dose	NNS
cord-015021-pol2qm74	8446	30	of	of	IN
cord-015021-pol2qm74	8446	31	cA2	ca2	NN
cord-015021-pol2qm74	8447	1	(	(	-LRB-
cord-015021-pol2qm74	8447	2	1,5,10	1,5,10	NNP
cord-015021-pol2qm74	8447	3	mg	mg	NNP
cord-015021-pol2qm74	8447	4	/	/	SYM
cord-015021-pol2qm74	8447	5	kg	kg	NNP
cord-015021-pol2qm74	8447	6	)	)	-RRB-
cord-015021-pol2qm74	8447	7	.	.	.
cord-015021-pol2qm74	8448	1	Stage	stage	NN
cord-015021-pol2qm74	8448	2	3	3	CD
cord-015021-pol2qm74	8448	3	was	be	VBD
cord-015021-pol2qm74	8448	4	a	a	DT
cord-015021-pol2qm74	8448	5	randomized	randomized	JJ
cord-015021-pol2qm74	8448	6	,	,	,
cord-015021-pol2qm74	8448	7	double	double	JJ
cord-015021-pol2qm74	8448	8	blind	blind	JJ
cord-015021-pol2qm74	8448	9	study	study	NN
cord-015021-pol2qm74	8448	10	in	in	IN
cord-015021-pol2qm74	8448	11	which	which	WDT
cord-015021-pol2qm74	8448	12	patients	patient	NNS
cord-015021-pol2qm74	8448	13	received	receive	VBD
cord-015021-pol2qm74	8448	14	a	a	DT
cord-015021-pol2qm74	8448	15	single	single	JJ
cord-015021-pol2qm74	8448	16	dose	dose	NN
cord-015021-pol2qm74	8448	17	of	of	IN
cord-015021-pol2qm74	8448	18	placebo	placebo	NN
cord-015021-pol2qm74	8448	19	or	or	CC
cord-015021-pol2qm74	8448	20	one	one	CD
cord-015021-pol2qm74	8448	21	of	of	IN
cord-015021-pol2qm74	8448	22	3	3	CD
cord-015021-pol2qm74	8448	23	doses	dose	NNS
cord-015021-pol2qm74	8448	24	of	of	IN
cord-015021-pol2qm74	8448	25	cA2	ca2	NN
cord-015021-pol2qm74	8448	26	(	(	-LRB-
cord-015021-pol2qm74	8448	27	0.1	0.1	CD
cord-015021-pol2qm74	8448	28	,	,	,
cord-015021-pol2qm74	8448	29	1	1	CD
cord-015021-pol2qm74	8448	30	,	,	,
cord-015021-pol2qm74	8448	31	10	10	CD
cord-015021-pol2qm74	8448	32	mg	mg	NNP
cord-015021-pol2qm74	8448	33	/	/	SYM
cord-015021-pol2qm74	8448	34	kg	kg	NNP
cord-015021-pol2qm74	8448	35	)	)	-RRB-
cord-015021-pol2qm74	8448	36	.	.	.
cord-015021-pol2qm74	8449	1	In	in	IN
cord-015021-pol2qm74	8449	2	addition	addition	NN
cord-015021-pol2qm74	8449	3	to	to	IN
cord-015021-pol2qm74	8449	4	usual	usual	JJ
cord-015021-pol2qm74	8449	5	laboratory	laboratory	NN
cord-015021-pol2qm74	8449	6	tests	test	NNS
cord-015021-pol2qm74	8449	7	,	,	,
cord-015021-pol2qm74	8449	8	the	the	DT
cord-015021-pol2qm74	8449	9	following	follow	VBG
cord-015021-pol2qm74	8449	10	assays	assay	NNS
cord-015021-pol2qm74	8449	11	were	be	VBD
cord-015021-pol2qm74	8449	12	performed	perform	VBN
cord-015021-pol2qm74	8449	13	:	:	:
cord-015021-pol2qm74	8449	14	chimeric	chimeric	JJ
cord-015021-pol2qm74	8449	15	anti	anti	JJ
cord-015021-pol2qm74	8449	16	-	-	JJ
cord-015021-pol2qm74	8449	17	TNF	TNF	NNP
cord-015021-pol2qm74	8449	18	concentration	concentration	NN
cord-015021-pol2qm74	8449	19	,	,	,
cord-015021-pol2qm74	8449	20	anti	anti	JJ
cord-015021-pol2qm74	8449	21	-	-	JJ
cord-015021-pol2qm74	8449	22	chimeric	chimeric	JJ
cord-015021-pol2qm74	8449	23	antibody	antibody	NN
cord-015021-pol2qm74	8449	24	,	,	,
cord-015021-pol2qm74	8449	25	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8449	26	,	,	,
cord-015021-pol2qm74	8449	27	TNF	TNF	NNP
cord-015021-pol2qm74	8449	28	,	,	,
cord-015021-pol2qm74	8449	29	IL-1	IL-1	NNP
cord-015021-pol2qm74	8449	30	,	,	,
cord-015021-pol2qm74	8449	31	and	and	CC
cord-015021-pol2qm74	8449	32	IL-6	IL-6	NNP
cord-015021-pol2qm74	8449	33	levels	level	NNS
cord-015021-pol2qm74	8449	34	.	.	.
cord-015021-pol2qm74	8450	1	A	a	DT
cord-015021-pol2qm74	8450	2	total	total	NN
cord-015021-pol2qm74	8450	3	of	of	IN
cord-015021-pol2qm74	8450	4	141	141	CD
cord-015021-pol2qm74	8450	5	patients	patient	NNS
cord-015021-pol2qm74	8450	6	were	be	VBD
cord-015021-pol2qm74	8450	7	enrolled	enrol	VBN
cord-015021-pol2qm74	8450	8	from	from	IN
cord-015021-pol2qm74	8450	9	13	13	CD
cord-015021-pol2qm74	8450	10	clinical	clinical	JJ
cord-015021-pol2qm74	8450	11	sites	site	NNS
cord-015021-pol2qm74	8450	12	(	(	-LRB-
cord-015021-pol2qm74	8450	13	20	20	CD
cord-015021-pol2qm74	8450	14	in	in	IN
cord-015021-pol2qm74	8450	15	stage	stage	NN
cord-015021-pol2qm74	8450	16	1	1	CD
cord-015021-pol2qm74	8450	17	,	,	,
cord-015021-pol2qm74	8450	18	60	60	CD
cord-015021-pol2qm74	8450	19	in	in	IN
cord-015021-pol2qm74	8450	20	stage	stage	NN
cord-015021-pol2qm74	8450	21	2	2	CD
cord-015021-pol2qm74	8450	22	and	and	CC
cord-015021-pol2qm74	8450	23	61	61	CD
cord-015021-pol2qm74	8450	24	in	in	IN
cord-015021-pol2qm74	8450	25	stage	stage	NN
cord-015021-pol2qm74	8450	26	3	3	CD
cord-015021-pol2qm74	8450	27	)	)	-RRB-
cord-015021-pol2qm74	8450	28	.	.	.
cord-015021-pol2qm74	8451	1	Primary	primary	JJ
cord-015021-pol2qm74	8451	2	analyses	analysis	NNS
cord-015021-pol2qm74	8451	3	were	be	VBD
cord-015021-pol2qm74	8451	4	performed	perform	VBN
cord-015021-pol2qm74	8451	5	on	on	IN
cord-015021-pol2qm74	8451	6	patients	patient	NNS
cord-015021-pol2qm74	8451	7	in	in	IN
cord-015021-pol2qm74	8451	8	stage	stage	NN
cord-015021-pol2qm74	8451	9	1	1	CD
cord-015021-pol2qm74	8451	10	and	and	CC
cord-015021-pol2qm74	8451	11	3	3	CD
cord-015021-pol2qm74	8451	12	.	.	.
cord-015021-pol2qm74	8452	1	There	there	EX
cord-015021-pol2qm74	8452	2	were	be	VBD
cord-015021-pol2qm74	8452	3	65	65	CD
cord-015021-pol2qm74	8452	4	patients	patient	NNS
cord-015021-pol2qm74	8452	5	who	who	WP
cord-015021-pol2qm74	8452	6	received	receive	VBD
cord-015021-pol2qm74	8452	7	cA2	ca2	NN
cord-015021-pol2qm74	8452	8	exclusively	exclusively	RB
cord-015021-pol2qm74	8452	9	and	and	CC
cord-015021-pol2qm74	8452	10	16	16	CD
cord-015021-pol2qm74	8452	11	patients	patient	NNS
cord-015021-pol2qm74	8452	12	received	receive	VBD
cord-015021-pol2qm74	8452	13	placebo	placebo	NN
cord-015021-pol2qm74	8452	14	.	.	.
cord-015021-pol2qm74	8453	1	Administration	administration	NN
cord-015021-pol2qm74	8453	2	of	of	IN
cord-015021-pol2qm74	8453	3	cA2	cA2	NNP
cord-015021-pol2qm74	8453	4	was	be	VBD
cord-015021-pol2qm74	8453	5	well	well	RB
cord-015021-pol2qm74	8453	6	tolerated	tolerate	VBN
cord-015021-pol2qm74	8453	7	at	at	IN
cord-015021-pol2qm74	8453	8	doses	dose	NNS
cord-015021-pol2qm74	8453	9	up	up	IN
cord-015021-pol2qm74	8453	10	to	to	TO
cord-015021-pol2qm74	8453	11	10	10	CD
cord-015021-pol2qm74	8453	12	mg	mg	NN
cord-015021-pol2qm74	8453	13	/	/	SYM
cord-015021-pol2qm74	8453	14	kg	kg	NNS
cord-015021-pol2qm74	8453	15	.	.	.
cord-015021-pol2qm74	8454	1	No	no	DT
cord-015021-pol2qm74	8454	2	patient	patient	NN
cord-015021-pol2qm74	8454	3	discontinued	discontinue	VBD
cord-015021-pol2qm74	8454	4	treatment	treatment	NN
cord-015021-pol2qm74	8454	5	due	due	IN
cord-015021-pol2qm74	8454	6	to	to	IN
cord-015021-pol2qm74	8454	7	adverse	adverse	JJ
cord-015021-pol2qm74	8454	8	events	event	NNS
cord-015021-pol2qm74	8454	9	.	.	.
cord-015021-pol2qm74	8455	1	Human	human	JJ
cord-015021-pol2qm74	8455	2	anti	anti	JJ
cord-015021-pol2qm74	8455	3	-	-	JJ
cord-015021-pol2qm74	8455	4	chimeric	chimeric	JJ
cord-015021-pol2qm74	8455	5	antibody	antibody	NN
cord-015021-pol2qm74	8455	6	responses	response	NNS
cord-015021-pol2qm74	8455	7	were	be	VBD
cord-015021-pol2qm74	8455	8	positive	positive	JJ
cord-015021-pol2qm74	8455	9	in	in	IN
cord-015021-pol2qm74	8455	10	61	61	CD
cord-015021-pol2qm74	8455	11	%	%	NN
cord-015021-pol2qm74	8455	12	(	(	-LRB-
cord-015021-pol2qm74	8455	13	30/49	30/49	CD
cord-015021-pol2qm74	8455	14	)	)	-RRB-
cord-015021-pol2qm74	8455	15	of	of	IN
cord-015021-pol2qm74	8455	16	evaluated	evaluate	VBN
cord-015021-pol2qm74	8455	17	patients	patient	NNS
cord-015021-pol2qm74	8455	18	.	.	.
cord-015021-pol2qm74	8456	1	Mean	Mean	NNP
cord-015021-pol2qm74	8456	2	Cma	Cma	NNP
cord-015021-pol2qm74	8456	3	×	×	NNP
cord-015021-pol2qm74	8456	4	and	and	CC
cord-015021-pol2qm74	8456	5	AUC	AUC	NNP
cord-015021-pol2qm74	8456	6	increased	increase	VBD
cord-015021-pol2qm74	8456	7	proportionally	proportionally	RB
cord-015021-pol2qm74	8456	8	with	with	IN
cord-015021-pol2qm74	8456	9	increasing	increase	VBG
cord-015021-pol2qm74	8456	10	doses	dose	NNS
cord-015021-pol2qm74	8456	11	of	of	IN
cord-015021-pol2qm74	8456	12	cA2	ca2	NN
cord-015021-pol2qm74	8456	13	.	.	.
cord-015021-pol2qm74	8457	1	The	the	DT
cord-015021-pol2qm74	8457	2	mean	mean	JJ
cord-015021-pol2qm74	8457	3	half	half	JJ
cord-015021-pol2qm74	8457	4	-	-	HYPH
cord-015021-pol2qm74	8457	5	life	life	NN
cord-015021-pol2qm74	8457	6	was	be	VBD
cord-015021-pol2qm74	8457	7	-70	-70	NN
cord-015021-pol2qm74	8457	8	hrs	hrs	NN
cord-015021-pol2qm74	8457	9	(	(	-LRB-
cord-015021-pol2qm74	8457	10	58	58	CD
cord-015021-pol2qm74	8457	11	-	-	SYM
cord-015021-pol2qm74	8457	12	96	96	CD
cord-015021-pol2qm74	8457	13	hrs	hrs	NN
cord-015021-pol2qm74	8457	14	)	)	-RRB-
cord-015021-pol2qm74	8457	15	.	.	.
cord-015021-pol2qm74	8458	1	A	a	DT
cord-015021-pol2qm74	8458	2	dose	dose	NN
cord-015021-pol2qm74	8458	3	related	relate	VBN
cord-015021-pol2qm74	8458	4	decrease	decrease	NN
cord-015021-pol2qm74	8458	5	in	in	IN
cord-015021-pol2qm74	8458	6	TNF	TNF	NNP
cord-015021-pol2qm74	8458	7	concentration	concentration	NN
cord-015021-pol2qm74	8458	8	was	be	VBD
cord-015021-pol2qm74	8458	9	observed	observe	VBN
cord-015021-pol2qm74	8458	10	1	1	CD
cord-015021-pol2qm74	8458	11	hr	hr	NN
cord-015021-pol2qm74	8458	12	post	post	NN
cord-015021-pol2qm74	8458	13	infusion	infusion	NN
cord-015021-pol2qm74	8458	14	of	of	IN
cord-015021-pol2qm74	8458	15	cA2	ca2	NN
cord-015021-pol2qm74	8458	16	.	.	.
cord-015021-pol2qm74	8459	1	TNF	TNF	NNP
cord-015021-pol2qm74	8459	2	is	be	VBZ
cord-015021-pol2qm74	8459	3	considered	consider	VBN
cord-015021-pol2qm74	8459	4	to	to	TO
cord-015021-pol2qm74	8459	5	be	be	VB
cord-015021-pol2qm74	8459	6	one	one	CD
cord-015021-pol2qm74	8459	7	of	of	IN
cord-015021-pol2qm74	8459	8	the	the	DT
cord-015021-pol2qm74	8459	9	central	central	JJ
cord-015021-pol2qm74	8459	10	endogenous	endogenous	JJ
cord-015021-pol2qm74	8459	11	mediators	mediator	NNS
cord-015021-pol2qm74	8459	12	for	for	IN
cord-015021-pol2qm74	8459	13	the	the	DT
cord-015021-pol2qm74	8459	14	inili'ation	inili'ation	NN
cord-015021-pol2qm74	8459	15	of	of	IN
cord-015021-pol2qm74	8459	16	the	the	DT
cord-015021-pol2qm74	8459	17	pathophysiological	pathophysiological	JJ
cord-015021-pol2qm74	8459	18	changes	change	NNS
cord-015021-pol2qm74	8459	19	in	in	IN
cord-015021-pol2qm74	8459	20	patients	patient	NNS
cord-015021-pol2qm74	8459	21	with	with	IN
cord-015021-pol2qm74	8459	22	sepsis	sepsis	NN
cord-015021-pol2qm74	8459	23	and	and	CC
cord-015021-pol2qm74	8459	24	septic	septic	JJ
cord-015021-pol2qm74	8459	25	shock	shock	NN
cord-015021-pol2qm74	8459	26	.	.	.
cord-015021-pol2qm74	8460	1	High	high	JJ
cord-015021-pol2qm74	8460	2	TNF	TNF	NNP
cord-015021-pol2qm74	8460	3	levels	level	NNS
cord-015021-pol2qm74	8460	4	were	be	VBD
cord-015021-pol2qm74	8460	5	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	8460	6	to	to	TO
cord-015021-pol2qm74	8460	7	correlate	correlate	VB
cord-015021-pol2qm74	8460	8	with	with	IN
cord-015021-pol2qm74	8460	9	patient	patient	JJ
cord-015021-pol2qm74	8460	10	outcome	outcome	NN
cord-015021-pol2qm74	8460	11	.	.	.
cord-015021-pol2qm74	8461	1	Blocking	block	VBG
cord-015021-pol2qm74	8461	2	or	or	CC
cord-015021-pol2qm74	8461	3	neutralising	neutralise	VBG
cord-015021-pol2qm74	8461	4	TNF	TNF	NNP
cord-015021-pol2qm74	8461	5	with	with	IN
cord-015021-pol2qm74	8461	6	specific	specific	JJ
cord-015021-pol2qm74	8461	7	antibodies	antibody	NNS
cord-015021-pol2qm74	8461	8	was	be	VBD
cord-015021-pol2qm74	8461	9	effective	effective	JJ
cord-015021-pol2qm74	8461	10	in	in	IN
cord-015021-pol2qm74	8461	11	preventing	prevent	VBG
cord-015021-pol2qm74	8461	12	death	death	NN
cord-015021-pol2qm74	8461	13	in	in	IN
cord-015021-pol2qm74	8461	14	some	some	DT
cord-015021-pol2qm74	8461	15	animal	animal	NN
cord-015021-pol2qm74	8461	16	modets	modet	NNS
cord-015021-pol2qm74	8461	17	of	of	IN
cord-015021-pol2qm74	8461	18	sepsis	sepsis	NN
cord-015021-pol2qm74	8461	19	.	.	.
cord-015021-pol2qm74	8462	1	In	in	IN
cord-015021-pol2qm74	8462	2	a	a	DT
cord-015021-pol2qm74	8462	3	placebo	placebo	NN
cord-015021-pol2qm74	8462	4	controlled	control	VBN
cord-015021-pol2qm74	8462	5	prospective	prospective	JJ
cord-015021-pol2qm74	8462	6	randomized	randomized	JJ
cord-015021-pol2qm74	8462	7	study	study	NN
cord-015021-pol2qm74	8462	8	we	-PRON-	PRP
cord-015021-pol2qm74	8462	9	tested	test	VBD
cord-015021-pol2qm74	8462	10	the	the	DT
cord-015021-pol2qm74	8462	11	mur~	mur~	CD
cord-015021-pol2qm74	8463	1	ne	ne	NNP
cord-015021-pol2qm74	8463	2	derived	derive	VBD
cord-015021-pol2qm74	8463	3	antibody	antibody	NN
cord-015021-pol2qm74	8463	4	MAK	MAK	NNP
cord-015021-pol2qm74	8463	5	195F.	195f.	CD
cord-015021-pol2qm74	8464	1	It	-PRON-	PRP
cord-015021-pol2qm74	8464	2	is	be	VBZ
cord-015021-pol2qm74	8464	3	a	a	DT
cord-015021-pol2qm74	8464	4	F(ab')2	F(ab')2	NNP
cord-015021-pol2qm74	8464	5	fragment	fragment	NN
cord-015021-pol2qm74	8464	6	.	.	.
cord-015021-pol2qm74	8465	1	The	the	DT
cord-015021-pol2qm74	8465	2	fragment	fragment	NN
cord-015021-pol2qm74	8465	3	rather	rather	RB
cord-015021-pol2qm74	8465	4	the	the	DT
cord-015021-pol2qm74	8465	5	complete	complete	JJ
cord-015021-pol2qm74	8465	6	antibody	antibody	NN
cord-015021-pol2qm74	8465	7	was	be	VBD
cord-015021-pol2qm74	8465	8	selected	select	VBN
cord-015021-pol2qm74	8465	9	in	in	IN
cord-015021-pol2qm74	8465	10	order	order	NN
cord-015021-pol2qm74	8465	11	to	to	TO
cord-015021-pol2qm74	8465	12	reduce	reduce	VB
cord-015021-pol2qm74	8465	13	the	the	DT
cord-015021-pol2qm74	8465	14	potential	potential	JJ
cord-015021-pol2qm74	8465	15	immunogenicity	immunogenicity	NN
cord-015021-pol2qm74	8465	16	and	and	CC
cord-015021-pol2qm74	8465	17	to	to	TO
cord-015021-pol2qm74	8465	18	facilitate	facilitate	VB
cord-015021-pol2qm74	8465	19	tissue	tissue	NN
cord-015021-pol2qm74	8465	20	penetration	penetration	NN
cord-015021-pol2qm74	8465	21	.	.	.
cord-015021-pol2qm74	8466	1	122	122	CD
cord-015021-pol2qm74	8466	2	patients	patient	NNS
cord-015021-pol2qm74	8466	3	with	with	IN
cord-015021-pol2qm74	8466	4	severe	severe	JJ
cord-015021-pol2qm74	8466	5	sepsis	sepsis	NN
cord-015021-pol2qm74	8466	6	or	or	CC
cord-015021-pol2qm74	8466	7	septic	septic	NN
cord-015021-pol2qm74	8466	8	shdck	shdck	NNP
cord-015021-pol2qm74	8466	9	were	be	VBD
cord-015021-pol2qm74	8466	10	enrolied	enrolie	VBN
cord-015021-pol2qm74	8466	11	in	in	IN
cord-015021-pol2qm74	8466	12	the	the	DT
cord-015021-pol2qm74	8466	13	study	study	NN
cord-015021-pol2qm74	8466	14	,	,	,
cord-015021-pol2qm74	8466	15	three	three	CD
cord-015021-pol2qm74	8466	16	different	different	JJ
cord-015021-pol2qm74	8466	17	doses	dose	NNS
cord-015021-pol2qm74	8466	18	of	of	IN
cord-015021-pol2qm74	8466	19	MAK	MAK	NNP
cord-015021-pol2qm74	8466	20	195F	195f	CD
cord-015021-pol2qm74	8466	21	or	or	CC
cord-015021-pol2qm74	8466	22	placebo	placebo	NN
cord-015021-pol2qm74	8466	23	were	be	VBD
cord-015021-pol2qm74	8466	24	administered	administer	VBN
cord-015021-pol2qm74	8466	25	(	(	-LRB-
cord-015021-pol2qm74	8466	26	0,1	0,1	CD
cord-015021-pol2qm74	8466	27	;	;	:
cord-015021-pol2qm74	8466	28	0,3	0,3	NFP
cord-015021-pol2qm74	8466	29	and	and	CC
cord-015021-pol2qm74	8466	30	I	-PRON-	PRP
cord-015021-pol2qm74	8466	31	mg	mg	NNP
cord-015021-pol2qm74	8466	32	/	/	SYM
cord-015021-pol2qm74	8466	33	kg	kg	NNP
cord-015021-pol2qm74	8466	34	)	)	-RRB-
cord-015021-pol2qm74	8466	35	over	over	IN
cord-015021-pol2qm74	8466	36	a	a	DT
cord-015021-pol2qm74	8466	37	perid	perid	NN
cord-015021-pol2qm74	8466	38	of	of	IN
cord-015021-pol2qm74	8466	39	72	72	CD
cord-015021-pol2qm74	8466	40	hours	hour	NNS
cord-015021-pol2qm74	8466	41	in	in	IN
cord-015021-pol2qm74	8466	42	random	random	JJ
cord-015021-pol2qm74	8466	43	order	order	NN
cord-015021-pol2qm74	8466	44	.	.	.
cord-015021-pol2qm74	8467	1	The	the	DT
cord-015021-pol2qm74	8467	2	patients	patient	NNS
cord-015021-pol2qm74	8467	3	were	be	VBD
cord-015021-pol2qm74	8467	4	evaluated	evaluate	VBN
cord-015021-pol2qm74	8467	5	for	for	IN
cord-015021-pol2qm74	8467	6	side	side	JJ
cord-015021-pol2qm74	8467	7	effects	effect	NNS
cord-015021-pol2qm74	8467	8	,	,	,
cord-015021-pol2qm74	8467	9	hemodynamics	hemodynamic	NNS
cord-015021-pol2qm74	8467	10	,	,	,
cord-015021-pol2qm74	8467	11	organ	organ	NN
cord-015021-pol2qm74	8467	12	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8467	13	,	,	,
cord-015021-pol2qm74	8467	14	cytokines	cytokine	NNS
cord-015021-pol2qm74	8467	15	(	(	-LRB-
cord-015021-pol2qm74	8467	16	IL	IL	NNP
cord-015021-pol2qm74	8467	17	6	6	CD
cord-015021-pol2qm74	8467	18	,	,	,
cord-015021-pol2qm74	8467	19	IL	IL	NNP
cord-015021-pol2qm74	8467	20	8	8	CD
cord-015021-pol2qm74	8467	21	and	and	CC
cord-015021-pol2qm74	8467	22	TNF	TNF	NNP
cord-015021-pol2qm74	8467	23	)	)	-RRB-
cord-015021-pol2qm74	8467	24	,	,	,
cord-015021-pol2qm74	8467	25	and	and	CC
cord-015021-pol2qm74	8467	26	outcome	outcome	NN
cord-015021-pol2qm74	8467	27	.	.	.
cord-015021-pol2qm74	8468	1	At	at	IN
cord-015021-pol2qm74	8468	2	this	this	DT
cord-015021-pol2qm74	8468	3	time	time	NN
cord-015021-pol2qm74	8468	4	only	only	RB
cord-015021-pol2qm74	8468	5	an	an	DT
cord-015021-pol2qm74	8468	6	interim	interim	JJ
cord-015021-pol2qm74	8468	7	analysis	analysis	NN
cord-015021-pol2qm74	8468	8	of	of	IN
cord-015021-pol2qm74	8468	9	60	60	CD
cord-015021-pol2qm74	8468	10	patients	patient	NNS
cord-015021-pol2qm74	8468	11	is	be	VBZ
cord-015021-pol2qm74	8468	12	available	available	JJ
cord-015021-pol2qm74	8468	13	I	-PRON-	PRP
cord-015021-pol2qm74	8468	14	indicating	indicate	VBG
cord-015021-pol2qm74	8468	15	that	that	IN
cord-015021-pol2qm74	8468	16	MAK	MAK	NNP
cord-015021-pol2qm74	8468	17	195F	195f	CD
cord-015021-pol2qm74	8468	18	in	in	IN
cord-015021-pol2qm74	8468	19	all	all	DT
cord-015021-pol2qm74	8468	20	3	3	CD
cord-015021-pol2qm74	8468	21	dosage	dosage	NN
cord-015021-pol2qm74	8468	22	groups	group	NNS
cord-015021-pol2qm74	8468	23	resulted	result	VBD
cord-015021-pol2qm74	8468	24	in	in	IN
cord-015021-pol2qm74	8468	25	a	a	DT
cord-015021-pol2qm74	8468	26	decrease	decrease	NN
cord-015021-pol2qm74	8468	27	in	in	IN
cord-015021-pol2qm74	8468	28	IL	IL	NNP
cord-015021-pol2qm74	8468	29	6	6	CD
cord-015021-pol2qm74	8468	30	.	.	.
cord-015021-pol2qm74	8469	1	This	this	DT
cord-015021-pol2qm74	8469	2	contrasted	contrast	VBD
cord-015021-pol2qm74	8469	3	to	to	IN
cord-015021-pol2qm74	8469	4	a	a	DT
cord-015021-pol2qm74	8469	5	further	far	RBR
cord-015021-pol2qm74	8469	6	in	in	IN
cord-015021-pol2qm74	8469	7	crease	crease	NN
cord-015021-pol2qm74	8469	8	of	of	IN
cord-015021-pol2qm74	8469	9	IL	IL	NNP
cord-015021-pol2qm74	8469	10	6	6	CD
cord-015021-pol2qm74	8469	11	in	in	IN
cord-015021-pol2qm74	8469	12	the	the	DT
cord-015021-pol2qm74	8469	13	placebo	placebo	NN
cord-015021-pol2qm74	8469	14	patients	patient	NNS
cord-015021-pol2qm74	8469	15	.	.	.
cord-015021-pol2qm74	8470	1	No	no	DT
cord-015021-pol2qm74	8470	2	serious	serious	JJ
cord-015021-pol2qm74	8470	3	side	side	NN
cord-015021-pol2qm74	8470	4	effects	effect	NNS
cord-015021-pol2qm74	8470	5	have	have	VBP
cord-015021-pol2qm74	8470	6	been	be	VBN
cord-015021-pol2qm74	8470	7	reported	report	VBN
cord-015021-pol2qm74	8470	8	so	so	RB
cord-015021-pol2qm74	8470	9	far	far	RB
cord-015021-pol2qm74	8470	10	.	.	.
cord-015021-pol2qm74	8471	1	A	a	DT
cord-015021-pol2qm74	8471	2	more	more	RBR
cord-015021-pol2qm74	8471	3	detailed	detailed	JJ
cord-015021-pol2qm74	8471	4	analysis	analysis	NN
cord-015021-pol2qm74	8471	5	on	on	IN
cord-015021-pol2qm74	8471	6	all	all	DT
cord-015021-pol2qm74	8471	7	122	122	CD
cord-015021-pol2qm74	8471	8	patients	patient	NNS
cord-015021-pol2qm74	8471	9	in	in	IN
cord-015021-pol2qm74	8471	10	the	the	DT
cord-015021-pol2qm74	8471	11	study	study	NN
cord-015021-pol2qm74	8471	12	will	will	MD
cord-015021-pol2qm74	8471	13	be	be	VB
cord-015021-pol2qm74	8471	14	presented	present	VBN
cord-015021-pol2qm74	8471	15	and	and	CC
cord-015021-pol2qm74	8471	16	discussed.$152	discussed.$152	VBN
cord-015021-pol2qm74	8471	17	S154	S154	NNP
cord-015021-pol2qm74	8471	18	Staubach	Staubach	NNP
cord-015021-pol2qm74	8471	19	,	,	,
cord-015021-pol2qm74	8471	20	K.H.	K.H.	NNP
cord-015021-pol2qm74	8471	21	,	,	,
cord-015021-pol2qm74	8471	22	Otto	Otto	NNP
cord-015021-pol2qm74	8471	23	,	,	,
cord-015021-pol2qm74	8471	24	V.	V.	NNP
cord-015021-pol2qm74	8471	25	,	,	,
cord-015021-pol2qm74	8471	26	Kooistra	Kooistra	NNP
cord-015021-pol2qm74	8471	27	,	,	,
cord-015021-pol2qm74	8471	28	A	A	NNP
cord-015021-pol2qm74	8471	29	,	,	,
cord-015021-pol2qm74	8471	30	,	,	,
cord-015021-pol2qm74	8471	31	RosenfeId	RosenfeId	NNP
cord-015021-pol2qm74	8471	32	,	,	,
cord-015021-pol2qm74	8471	33	J.A.	J.A.	NNP
cord-015021-pol2qm74	8471	34	,	,	,
cord-015021-pol2qm74	8471	35	Bruch	Bruch	NNP
cord-015021-pol2qm74	8471	36	,	,	,
cord-015021-pol2qm74	8471	37	H.P.	H.P.	NNP
cord-015021-pol2qm74	8471	38	,	,	,
cord-015021-pol2qm74	8471	39	Univ	Univ	NNP
cord-015021-pol2qm74	8471	40	.	.	.
cord-015021-pol2qm74	8472	1	Lfibeek	Lfibeek	NNP
cord-015021-pol2qm74	8472	2	,	,	,
cord-015021-pol2qm74	8472	3	Germany	Germany	NNP
cord-015021-pol2qm74	8473	1	Once	once	IN
cord-015021-pol2qm74	8473	2	endotoxinemia	endotoxinemia	NN
cord-015021-pol2qm74	8473	3	occurs	occur	VBZ
cord-015021-pol2qm74	8473	4	in	in	IN
cord-015021-pol2qm74	8473	5	sepsis	sepsis	NN
cord-015021-pol2qm74	8473	6	a	a	DT
cord-015021-pol2qm74	8473	7	vieieus	vieieus	NN
cord-015021-pol2qm74	8473	8	cycle	cycle	NN
cord-015021-pol2qm74	8473	9	with	with	IN
cord-015021-pol2qm74	8473	10	translocation	translocation	NN
cord-015021-pol2qm74	8473	11	of	of	IN
cord-015021-pol2qm74	8473	12	ET	ET	NNP
cord-015021-pol2qm74	8473	13	can	can	MD
cord-015021-pol2qm74	8473	14	be	be	VB
cord-015021-pol2qm74	8473	15	established	establish	VBN
cord-015021-pol2qm74	8473	16	.	.	.
cord-015021-pol2qm74	8474	1	Increasing	increase	VBG
cord-015021-pol2qm74	8474	2	the	the	DT
cord-015021-pol2qm74	8474	3	clearance	clearance	NN
cord-015021-pol2qm74	8474	4	capacity	capacity	NN
cord-015021-pol2qm74	8474	5	for	for	IN
cord-015021-pol2qm74	8474	6	ET	ET	NNP
cord-015021-pol2qm74	8474	7	would	would	MD
cord-015021-pol2qm74	8474	8	therapeutically	therapeutically	RB
cord-015021-pol2qm74	8474	9	be	be	VB
cord-015021-pol2qm74	8474	10	the	the	DT
cord-015021-pol2qm74	8474	11	ulimate	ulimate	JJ
cord-015021-pol2qm74	8474	12	aim	aim	NN
cord-015021-pol2qm74	8474	13	.	.	.
cord-015021-pol2qm74	8475	1	We	-PRON-	PRP
cord-015021-pol2qm74	8475	2	developed	develop	VBD
cord-015021-pol2qm74	8475	3	a	a	DT
cord-015021-pol2qm74	8475	4	new	new	JJ
cord-015021-pol2qm74	8475	5	ET	ET	NNP
cord-015021-pol2qm74	8475	6	on	on	IN
cord-015021-pol2qm74	8475	7	-	-	HYPH
cord-015021-pol2qm74	8475	8	line	line	NN
cord-015021-pol2qm74	8475	9	adsorption	adsorption	NN
cord-015021-pol2qm74	8475	10	(	(	-LRB-
cord-015021-pol2qm74	8475	11	AD	ad	NN
cord-015021-pol2qm74	8475	12	)	)	-RRB-
cord-015021-pol2qm74	8475	13	system	system	NN
cord-015021-pol2qm74	8475	14	in	in	IN
cord-015021-pol2qm74	8475	15	whole	whole	JJ
cord-015021-pol2qm74	8475	16	blood	blood	NN
cord-015021-pol2qm74	8475	17	by	by	IN
cord-015021-pol2qm74	8475	18	means	mean	NNS
cord-015021-pol2qm74	8475	19	of	of	IN
cord-015021-pol2qm74	8475	20	Polymyxin	Polymyxin	NNP
cord-015021-pol2qm74	8475	21	B	B	NNP
cord-015021-pol2qm74	8475	22	(	(	-LRB-
cord-015021-pol2qm74	8475	23	PB	PB	NNP
cord-015021-pol2qm74	8475	24	)	)	-RRB-
cord-015021-pol2qm74	8475	25	coupled	couple	VBN
cord-015021-pol2qm74	8475	26	eovalently	eovalently	RB
cord-015021-pol2qm74	8475	27	to	to	IN
cord-015021-pol2qm74	8475	28	a	a	DT
cord-015021-pol2qm74	8475	29	matrix	matrix	NN
cord-015021-pol2qm74	8475	30	(	(	-LRB-
cord-015021-pol2qm74	8475	31	acrylic	acrylic	NN
cord-015021-pol2qm74	8475	32	particles	particle	NNS
cord-015021-pol2qm74	8475	33	)	)	-RRB-
cord-015021-pol2qm74	8475	34	via	via	IN
cord-015021-pol2qm74	8475	35	a	a	DT
cord-015021-pol2qm74	8475	36	13	13	CD
cord-015021-pol2qm74	8475	37	atom	atom	NN
cord-015021-pol2qm74	8475	38	-	-	HYPH
cord-015021-pol2qm74	8475	39	chain	chain	NN
cord-015021-pol2qm74	8475	40	spacer	spacer	NN
cord-015021-pol2qm74	8475	41	.	.	.
cord-015021-pol2qm74	8476	1	The	the	DT
cord-015021-pol2qm74	8476	2	detoxification	detoxification	NN
cord-015021-pol2qm74	8476	3	capacity	capacity	NN
cord-015021-pol2qm74	8476	4	was	be	VBD
cord-015021-pol2qm74	8476	5	150	150	CD
cord-015021-pol2qm74	8476	6	ug[ET	ug[ET	NNP
cord-015021-pol2qm74	8476	7	/	/	SYM
cord-015021-pol2qm74	8476	8	ml	ml	NN
cord-015021-pol2qm74	8476	9	column	column	NN
cord-015021-pol2qm74	8476	10	material	material	NN
cord-015021-pol2qm74	8476	11	.	.	.
cord-015021-pol2qm74	8477	1	The	the	DT
cord-015021-pol2qm74	8477	2	biocompatbility	biocompatbility	NN
cord-015021-pol2qm74	8477	3	resulted	result	VBD
cord-015021-pol2qm74	8477	4	in	in	IN
cord-015021-pol2qm74	8477	5	90~	90~	CD
cord-015021-pol2qm74	8477	6	platelet	platelet	NN
cord-015021-pol2qm74	8477	7	recovery	recovery	NN
cord-015021-pol2qm74	8477	8	.	.	.
cord-015021-pol2qm74	8478	1	The	the	DT
cord-015021-pol2qm74	8478	2	column	column	NN
cord-015021-pol2qm74	8478	3	contained	contain	VBD
cord-015021-pol2qm74	8478	4	7	7	CD
cord-015021-pol2qm74	8478	5	ml	ml	NNS
cord-015021-pol2qm74	8478	6	of	of	IN
cord-015021-pol2qm74	8478	7	ADmaterial	ADmaterial	NNP
cord-015021-pol2qm74	8478	8	and	and	CC
cord-015021-pol2qm74	8478	9	was	be	VBD
cord-015021-pol2qm74	8478	10	sterilized	sterilize	VBN
cord-015021-pol2qm74	8478	11	by	by	IN
cord-015021-pol2qm74	8478	12	high	high	JJ
cord-015021-pol2qm74	8478	13	steam	steam	NN
cord-015021-pol2qm74	8478	14	autoclave	autoclave	NN
cord-015021-pol2qm74	8478	15	,	,	,
cord-015021-pol2qm74	8478	16	Anticoagulation	Anticoagulation	NNP
cord-015021-pol2qm74	8478	17	was	be	VBD
cord-015021-pol2qm74	8478	18	achieved	achieve	VBN
cord-015021-pol2qm74	8478	19	by	by	IN
cord-015021-pol2qm74	8478	20	heparine	heparine	NNP
cord-015021-pol2qm74	8478	21	1.000	1.000	CD
cord-015021-pol2qm74	8478	22	IU	IU	NNP
cord-015021-pol2qm74	8478	23	/	/	SYM
cord-015021-pol2qm74	8478	24	h	h	NN
cord-015021-pol2qm74	8478	25	in	in	IN
cord-015021-pol2qm74	8478	26	the	the	DT
cord-015021-pol2qm74	8478	27	inflowline	inflowline	NN
cord-015021-pol2qm74	8478	28	after	after	IN
cord-015021-pol2qm74	8478	29	bolus	bolus	NN
cord-015021-pol2qm74	8478	30	injection	injection	NN
cord-015021-pol2qm74	8478	31	of	of	IN
cord-015021-pol2qm74	8478	32	5.000	5.000	CD
cord-015021-pol2qm74	8478	33	IU	IU	NNP
cord-015021-pol2qm74	8478	34	.	.	.
cord-015021-pol2qm74	8479	1	HP	HP	NNP
cord-015021-pol2qm74	8479	2	was	be	VBD
cord-015021-pol2qm74	8479	3	performed	perform	VBN
cord-015021-pol2qm74	8479	4	on	on	IN
cord-015021-pol2qm74	8479	5	8	8	CD
cord-015021-pol2qm74	8479	6	pigs	pig	NNS
cord-015021-pol2qm74	8479	7	at	at	IN
cord-015021-pol2qm74	8479	8	a	a	DT
cord-015021-pol2qm74	8479	9	rate	rate	NN
cord-015021-pol2qm74	8479	10	of	of	IN
cord-015021-pol2qm74	8479	11	50	50	CD
cord-015021-pol2qm74	8479	12	ml	ml	NNS
cord-015021-pol2qm74	8479	13	/	/	SYM
cord-015021-pol2qm74	8479	14	min	min	NN
cord-015021-pol2qm74	8479	15	by	by	IN
cord-015021-pol2qm74	8479	16	means	mean	NNS
cord-015021-pol2qm74	8479	17	of	of	IN
cord-015021-pol2qm74	8479	18	a	a	DT
cord-015021-pol2qm74	8479	19	roller	roller	NN
cord-015021-pol2qm74	8479	20	-	-	HYPH
cord-015021-pol2qm74	8479	21	pump	pump	NN
cord-015021-pol2qm74	8479	22	until	until	IN
cord-015021-pol2qm74	8479	23	the	the	DT
cord-015021-pol2qm74	8479	24	animals	animal	NNS
cord-015021-pol2qm74	8479	25	succumbed	succumb	VBD
cord-015021-pol2qm74	8479	26	(	(	-LRB-
cord-015021-pol2qm74	8479	27	H	h	NN
cord-015021-pol2qm74	8479	28	)	)	-RRB-
cord-015021-pol2qm74	8479	29	.	.	.
cord-015021-pol2qm74	8480	1	8	8	CD
cord-015021-pol2qm74	8480	2	animals	animal	NNS
cord-015021-pol2qm74	8480	3	served	serve	VBD
cord-015021-pol2qm74	8480	4	as	as	IN
cord-015021-pol2qm74	8480	5	controls	control	NNS
cord-015021-pol2qm74	8480	6	(	(	-LRB-
cord-015021-pol2qm74	8480	7	C	C	NNP
cord-015021-pol2qm74	8480	8	)	)	-RRB-
cord-015021-pol2qm74	8480	9	.	.	.
cord-015021-pol2qm74	8481	1	Serum	serum	NN
cord-015021-pol2qm74	8481	2	ET	ET	NNP
cord-015021-pol2qm74	8481	3	levels	level	NNS
cord-015021-pol2qm74	8481	4	rose	rise	VBD
cord-015021-pol2qm74	8481	5	from	from	IN
cord-015021-pol2qm74	8481	6	3.40	3.40	CD
cord-015021-pol2qm74	8481	7	pg	pg	NNP
cord-015021-pol2qm74	8481	8	/	/	SYM
cord-015021-pol2qm74	8481	9	ml	ml	NN
cord-015021-pol2qm74	8481	10	to	to	IN
cord-015021-pol2qm74	8481	11	74,9	74,9	CD
cord-015021-pol2qm74	8481	12	pg	pg	NN
cord-015021-pol2qm74	8481	13	/	/	SYM
cord-015021-pol2qm74	8481	14	ml	ml	NN
cord-015021-pol2qm74	8481	15	after	after	IN
cord-015021-pol2qm74	8481	16	5	5	CD
cord-015021-pol2qm74	8481	17	hours	hour	NNS
cord-015021-pol2qm74	8481	18	in	in	IN
cord-015021-pol2qm74	8481	19	the	the	DT
cord-015021-pol2qm74	8481	20	C	C	NNP
cord-015021-pol2qm74	8481	21	and	and	CC
cord-015021-pol2qm74	8481	22	from	from	IN
cord-015021-pol2qm74	8481	23	2.77	2.77	CD
cord-015021-pol2qm74	8481	24	pg	pg	NNP
cord-015021-pol2qm74	8481	25	/	/	SYM
cord-015021-pol2qm74	8481	26	ml	ml	XX
cord-015021-pol2qm74	8481	27	only	only	RB
cord-015021-pol2qm74	8481	28	to	to	IN
cord-015021-pol2qm74	8481	29	28	28	CD
cord-015021-pol2qm74	8481	30	pg	pg	NNP
cord-015021-pol2qm74	8481	31	/	/	SYM
cord-015021-pol2qm74	8481	32	ml	ml	XX
cord-015021-pol2qm74	8481	33	in	in	IN
cord-015021-pol2qm74	8481	34	the	the	DT
cord-015021-pol2qm74	8481	35	H	H	NNP
cord-015021-pol2qm74	8481	36	group	group	NN
cord-015021-pol2qm74	8481	37	after	after	IN
cord-015021-pol2qm74	8481	38	7	7	CD
cord-015021-pol2qm74	8481	39	hours	hour	NNS
cord-015021-pol2qm74	8481	40	whieh	whieh	NNP
cord-015021-pol2qm74	8481	41	was	be	VBD
cord-015021-pol2qm74	8481	42	highly	highly	RB
cord-015021-pol2qm74	8481	43	significant	significant	JJ
cord-015021-pol2qm74	8481	44	.	.	.
cord-015021-pol2qm74	8482	1	Survival	survival	NN
cord-015021-pol2qm74	8482	2	time	time	NN
cord-015021-pol2qm74	8482	3	could	could	MD
cord-015021-pol2qm74	8482	4	be	be	VB
cord-015021-pol2qm74	8482	5	extrended	extrende	VBN
cord-015021-pol2qm74	8482	6	from	from	IN
cord-015021-pol2qm74	8482	7	216	216	CD
cord-015021-pol2qm74	8482	8	to	to	IN
cord-015021-pol2qm74	8482	9	313	313	CD
cord-015021-pol2qm74	8482	10	min	min	NN
cord-015021-pol2qm74	8482	11	.	.	.
cord-015021-pol2qm74	8483	1	Results	result	NNS
cord-015021-pol2qm74	8483	2	are	be	VBP
cord-015021-pol2qm74	8483	3	listed	list	VBN
cord-015021-pol2qm74	8483	4	in	in	IN
cord-015021-pol2qm74	8483	5	the	the	DT
cord-015021-pol2qm74	8483	6	following	follow	VBG
cord-015021-pol2qm74	8483	7	L.	L.	NNP
cord-015021-pol2qm74	8483	8	Blinzler	Blinzler	NNP
cord-015021-pol2qm74	8483	9	,	,	,
cord-015021-pol2qm74	8483	10	P.	P.	NNP
cord-015021-pol2qm74	8483	11	Zaar	Zaar	NNP
cord-015021-pol2qm74	8483	12	,	,	,
cord-015021-pol2qm74	8483	13	M.	M.	NNP
cord-015021-pol2qm74	8483	14	Leier	Leier	NNP
cord-015021-pol2qm74	8483	15	,	,	,
cord-015021-pol2qm74	8483	16	R.	R.	NNP
cord-015021-pol2qm74	8483	17	B(2rger	B(2rger	NNP
cord-015021-pol2qm74	8483	18	,	,	,
cord-015021-pol2qm74	8483	19	D.	D.	NNP
cord-015021-pol2qm74	8483	20	Heuser	Heuser	NNP
cord-015021-pol2qm74	8483	21	Clinic	Clinic	NNP
cord-015021-pol2qm74	8483	22	of	of	IN
cord-015021-pol2qm74	8483	23	Anaesthesiology	Anaesthesiology	NNP
cord-015021-pol2qm74	8483	24	,	,	,
cord-015021-pol2qm74	8483	25	City	City	NNP
cord-015021-pol2qm74	8483	26	Hospital	Hospital	NNP
cord-015021-pol2qm74	8483	27	Nuremberg	Nuremberg	NNP
cord-015021-pol2qm74	8483	28	,	,	,
cord-015021-pol2qm74	8483	29	Germany	Germany	NNP
cord-015021-pol2qm74	8483	30	Sepsis	Sepsis	NNP
cord-015021-pol2qm74	8483	31	and	and	CC
cord-015021-pol2qm74	8483	32	multiple	multiple	JJ
cord-015021-pol2qm74	8483	33	organ	organ	NN
cord-015021-pol2qm74	8483	34	failure	failure	NN
cord-015021-pol2qm74	8483	35	(	(	-LRB-
cord-015021-pol2qm74	8483	36	MOF	MOF	NNP
cord-015021-pol2qm74	8483	37	)	)	-RRB-
cord-015021-pol2qm74	8483	38	are	be	VBP
cord-015021-pol2qm74	8483	39	still	still	RB
cord-015021-pol2qm74	8483	40	related	relate	VBN
cord-015021-pol2qm74	8483	41	with	with	IN
cord-015021-pol2qm74	8483	42	poor	poor	JJ
cord-015021-pol2qm74	8483	43	prognosis	prognosis	NN
cord-015021-pol2qm74	8483	44	inspire	inspire	NN
cord-015021-pol2qm74	8483	45	of	of	IN
cord-015021-pol2qm74	8483	46	pharmacological	pharmacological	JJ
cord-015021-pol2qm74	8483	47	and	and	CC
cord-015021-pol2qm74	8483	48	technical	technical	JJ
cord-015021-pol2qm74	8483	49	progress	progress	NN
cord-015021-pol2qm74	8483	50	.	.	.
cord-015021-pol2qm74	8484	1	Impressed	impress	VBN
cord-015021-pol2qm74	8484	2	by	by	IN
cord-015021-pol2qm74	8484	3	revealing	reveal	VBG
cord-015021-pol2qm74	8484	4	reports	report	NNS
cord-015021-pol2qm74	8484	5	about	about	IN
cord-015021-pol2qm74	8484	6	blood	blood	NN
cord-015021-pol2qm74	8484	7	purification	purification	NN
cord-015021-pol2qm74	8484	8	the	the	DT
cord-015021-pol2qm74	8484	9	continuous	continuous	JJ
cord-015021-pol2qm74	8484	10	veno	veno	NNP
cord-015021-pol2qm74	8484	11	-	-	HYPH
cord-015021-pol2qm74	8484	12	venous	venous	JJ
cord-015021-pol2qm74	8484	13	hemofiltration	hemofiltration	NNP
cord-015021-pol2qm74	8484	14	(	(	-LRB-
cord-015021-pol2qm74	8484	15	CVVH	CVVH	NNP
cord-015021-pol2qm74	8484	16	)	)	-RRB-
cord-015021-pol2qm74	8484	17	was	be	VBD
cord-015021-pol2qm74	8484	18	used	use	VBN
cord-015021-pol2qm74	8484	19	as	as	IN
cord-015021-pol2qm74	8484	20	supporting	support	VBG
cord-015021-pol2qm74	8484	21	treatment	treatment	NN
cord-015021-pol2qm74	8484	22	beside	beside	IN
cord-015021-pol2qm74	8484	23	the	the	DT
cord-015021-pol2qm74	8484	24	critical	critical	JJ
cord-015021-pol2qm74	8484	25	cam	cam	NN
cord-015021-pol2qm74	8484	26	basic	basic	JJ
cord-015021-pol2qm74	8484	27	therapy	therapy	NN
cord-015021-pol2qm74	8484	28	of	of	IN
cord-015021-pol2qm74	8484	29	MOF	MOF	NNP
cord-015021-pol2qm74	8484	30	.	.	.
cord-015021-pol2qm74	8485	1	From	from	IN
cord-015021-pol2qm74	8485	2	1989	1989	CD
cord-015021-pol2qm74	8485	3	to	to	IN
cord-015021-pol2qm74	8485	4	1991	1991	CD
cord-015021-pol2qm74	8485	5	78	78	CD
cord-015021-pol2qm74	8485	6	consecutive	consecutive	JJ
cord-015021-pol2qm74	8485	7	patients	patient	NNS
cord-015021-pol2qm74	8485	8	were	be	VBD
cord-015021-pol2qm74	8485	9	treated	treat	VBN
cord-015021-pol2qm74	8485	10	by	by	IN
cord-015021-pol2qm74	8485	11	CWH	CWH	NNP
cord-015021-pol2qm74	8485	12	.	.	.
cord-015021-pol2qm74	8486	1	MOF	MOF	NNP
cord-015021-pol2qm74	8486	2	was	be	VBD
cord-015021-pol2qm74	8486	3	caused	cause	VBN
cord-015021-pol2qm74	8486	4	by	by	IN
cord-015021-pol2qm74	8486	5	hemolrhagic	hemolrhagic	JJ
cord-015021-pol2qm74	8486	6	-	-	HYPH
cord-015021-pol2qm74	8486	7	traumatic	traumatic	JJ
cord-015021-pol2qm74	8486	8	noxa	noxa	NN
cord-015021-pol2qm74	8486	9	in	in	IN
cord-015021-pol2qm74	8486	10	21	21	CD
cord-015021-pol2qm74	8486	11	°	°	NNS
cord-015021-pol2qm74	8486	12	,4	,4	NNS
cord-015021-pol2qm74	8486	13	and	and	CC
cord-015021-pol2qm74	8486	14	by	by	IN
cord-015021-pol2qm74	8486	15	septic	septic	JJ
cord-015021-pol2qm74	8486	16	-	-	HYPH
cord-015021-pol2qm74	8486	17	toxic	toxic	JJ
cord-015021-pol2qm74	8486	18	event	event	NN
cord-015021-pol2qm74	8486	19	in	in	IN
cord-015021-pol2qm74	8486	20	79	79	CD
cord-015021-pol2qm74	8486	21	%	%	NN
cord-015021-pol2qm74	8486	22	.	.	.
cord-015021-pol2qm74	8487	1	All	all	DT
cord-015021-pol2qm74	8487	2	patients	patient	NNS
cord-015021-pol2qm74	8487	3	required	require	VBD
cord-015021-pol2qm74	8487	4	mechanical	mechanical	JJ
cord-015021-pol2qm74	8487	5	ventilation	ventilation	NN
cord-015021-pol2qm74	8487	6	(	(	-LRB-
cord-015021-pol2qm74	8487	7	FiO2>0	fio2>0	CD
cord-015021-pol2qm74	8487	8	,	,	,
cord-015021-pol2qm74	8487	9	5	5	CD
cord-015021-pol2qm74	8487	10	)	)	-RRB-
cord-015021-pol2qm74	8487	11	.	.	.
cord-015021-pol2qm74	8488	1	86	86	CD
cord-015021-pol2qm74	8488	2	°	°	NN
cord-015021-pol2qm74	8488	3	4	4	CD
cord-015021-pol2qm74	8488	4	showed	show	VBD
cord-015021-pol2qm74	8488	5	hyperdynamic	hyperdynamic	JJ
cord-015021-pol2qm74	8488	6	shock	shock	NN
cord-015021-pol2qm74	8488	7	.	.	.
cord-015021-pol2qm74	8489	1	85	85	CD
cord-015021-pol2qm74	8489	2	%	%	NN
cord-015021-pol2qm74	8489	3	had	have	VBD
cord-015021-pol2qm74	8489	4	renal	renal	JJ
cord-015021-pol2qm74	8489	5	and	and	CC
cord-015021-pol2qm74	8489	6	53	53	CD
cord-015021-pol2qm74	8489	7	%	%	NN
cord-015021-pol2qm74	8489	8	hepatic	hepatic	JJ
cord-015021-pol2qm74	8489	9	failure	failure	NN
cord-015021-pol2qm74	8489	10	.	.	.
cord-015021-pol2qm74	8490	1	Medium	Medium	NNP
cord-015021-pol2qm74	8490	2	APPACHE	APPACHE	NNP
cord-015021-pol2qm74	8490	3	II	II	NNP
cord-015021-pol2qm74	8490	4	score	score	NN
cord-015021-pol2qm74	8490	5	amounted	amount	VBD
cord-015021-pol2qm74	8490	6	to	to	IN
cord-015021-pol2qm74	8490	7	29,8	29,8	CD
cord-015021-pol2qm74	8490	8	points	point	NNS
cord-015021-pol2qm74	8490	9	.	.	.
cord-015021-pol2qm74	8491	1	CVVH	CVVH	NNP
cord-015021-pol2qm74	8491	2	was	be	VBD
cord-015021-pol2qm74	8491	3	performed	perform	VBN
cord-015021-pol2qm74	8491	4	in	in	IN
cord-015021-pol2qm74	8491	5	postdilution	postdilution	NN
cord-015021-pol2qm74	8491	6	mode	mode	NN
cord-015021-pol2qm74	8491	7	with	with	IN
cord-015021-pol2qm74	8491	8	a	a	DT
cord-015021-pol2qm74	8491	9	polyamide	polyamide	NN
cord-015021-pol2qm74	8491	10	membrane	membrane	NN
cord-015021-pol2qm74	8491	11	(	(	-LRB-
cord-015021-pol2qm74	8491	12	FH	FH	NNP
cord-015021-pol2qm74	8491	13	66	66	CD
cord-015021-pol2qm74	8491	14	)	)	-RRB-
cord-015021-pol2qm74	8491	15	and	and	CC
cord-015021-pol2qm74	8491	16	high	high	JJ
cord-015021-pol2qm74	8491	17	volume	volume	NN
cord-015021-pol2qm74	8491	18	exchange	exchange	NN
cord-015021-pol2qm74	8491	19	(	(	-LRB-
cord-015021-pol2qm74	8491	20	50	50	CD
cord-015021-pol2qm74	8491	21	l	l	NN
cord-015021-pol2qm74	8491	22	/	/	SYM
cord-015021-pol2qm74	8491	23	die	die	NN
cord-015021-pol2qm74	8491	24	)	)	-RRB-
cord-015021-pol2qm74	8491	25	.	.	.
cord-015021-pol2qm74	8492	1	Anticoagulation	Anticoagulation	NNP
cord-015021-pol2qm74	8492	2	was	be	VBD
cord-015021-pol2qm74	8492	3	done	do	VBN
cord-015021-pol2qm74	8492	4	with	with	IN
cord-015021-pol2qm74	8492	5	heparin	heparin	NN
cord-015021-pol2qm74	8492	6	.	.	.
cord-015021-pol2qm74	8493	1	Hemofiltration	Hemofiltration	NNP
cord-015021-pol2qm74	8493	2	in	in	IN
cord-015021-pol2qm74	8493	3	MOF	MOF	NNP
cord-015021-pol2qm74	8493	4	was	be	VBD
cord-015021-pol2qm74	8493	5	installed	instal	VBN
cord-015021-pol2qm74	8493	6	,	,	,
cord-015021-pol2qm74	8493	7	when	when	WRB
cord-015021-pol2qm74	8493	8	critical	critical	JJ
cord-015021-pol2qm74	8493	9	cam	cam	NN
cord-015021-pol2qm74	8493	10	basic	basic	JJ
cord-015021-pol2qm74	8493	11	therapy	therapy	NN
cord-015021-pol2qm74	8493	12	including	include	VBG
cord-015021-pol2qm74	8493	13	adequate	adequate	JJ
cord-015021-pol2qm74	8493	14	respiratory	respiratory	JJ
cord-015021-pol2qm74	8493	15	and	and	CC
cord-015021-pol2qm74	8493	16	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	8493	17	management	management	NN
cord-015021-pol2qm74	8493	18	,	,	,
cord-015021-pol2qm74	8493	19	pamnteral	pamnteral	JJ
cord-015021-pol2qm74	8493	20	nutrition	nutrition	NN
cord-015021-pol2qm74	8493	21	,	,	,
cord-015021-pol2qm74	8493	22	antibiotic	antibiotic	JJ
cord-015021-pol2qm74	8493	23	treatment	treatment	NN
cord-015021-pol2qm74	8493	24	,	,	,
cord-015021-pol2qm74	8493	25	etc	etc	FW
cord-015021-pol2qm74	8493	26	.	.	FW
cord-015021-pol2qm74	8493	27	,	,	,
cord-015021-pol2qm74	8493	28	failed	fail	VBD
cord-015021-pol2qm74	8493	29	to	to	TO
cord-015021-pol2qm74	8493	30	stabilize	stabilize	VB
cord-015021-pol2qm74	8493	31	organ	organ	NN
cord-015021-pol2qm74	8493	32	functions	function	NNS
cord-015021-pol2qm74	8493	33	.	.	.
cord-015021-pol2qm74	8494	1	During	during	IN
cord-015021-pol2qm74	8494	2	consequent	consequent	JJ
cord-015021-pol2qm74	8494	3	application	application	NN
cord-015021-pol2qm74	8494	4	of	of	IN
cord-015021-pol2qm74	8494	5	CVVH	CVVH	NNP
cord-015021-pol2qm74	8494	6	most	most	JJS
cord-015021-pol2qm74	8494	7	of	of	IN
cord-015021-pol2qm74	8494	8	these	these	DT
cord-015021-pol2qm74	8494	9	patients	patient	NNS
cord-015021-pol2qm74	8494	10	showed	show	VBD
cord-015021-pol2qm74	8494	11	improvement	improvement	NN
cord-015021-pol2qm74	8494	12	of	of	IN
cord-015021-pol2qm74	8494	13	their	-PRON-	PRP$
cord-015021-pol2qm74	8494	14	clinical	clinical	JJ
cord-015021-pol2qm74	8494	15	course	course	NN
cord-015021-pol2qm74	8494	16	.	.	.
cord-015021-pol2qm74	8495	1	Pulmonary	pulmonary	JJ
cord-015021-pol2qm74	8495	2	stabilization	stabilization	NN
cord-015021-pol2qm74	8495	3	was	be	VBD
cord-015021-pol2qm74	8495	4	seen	see	VBN
cord-015021-pol2qm74	8495	5	in	in	IN
cord-015021-pol2qm74	8495	6	71	71	CD
cord-015021-pol2qm74	8495	7	%	%	NN
cord-015021-pol2qm74	8495	8	,	,	,
cord-015021-pol2qm74	8495	9	hemodynamic	hemodynamic	JJ
cord-015021-pol2qm74	8495	10	in	in	IN
cord-015021-pol2qm74	8495	11	68	68	CD
cord-015021-pol2qm74	8495	12	%	%	NN
cord-015021-pol2qm74	8495	13	and	and	CC
cord-015021-pol2qm74	8495	14	renal	renal	JJ
cord-015021-pol2qm74	8495	15	in	in	IN
cord-015021-pol2qm74	8495	16	66	66	CD
cord-015021-pol2qm74	8495	17	%	%	NN
cord-015021-pol2qm74	8495	18	of	of	IN
cord-015021-pol2qm74	8495	19	the	the	DT
cord-015021-pol2qm74	8495	20	cases	case	NNS
cord-015021-pol2qm74	8495	21	.	.	.
cord-015021-pol2qm74	8496	1	42	42	CD
cord-015021-pol2qm74	8496	2	%	%	NN
cord-015021-pol2qm74	8496	3	of	of	IN
cord-015021-pol2qm74	8496	4	the	the	DT
cord-015021-pol2qm74	8496	5	patients	patient	NNS
cord-015021-pol2qm74	8496	6	survived	survive	VBD
cord-015021-pol2qm74	8496	7	and	and	CC
cord-015021-pol2qm74	8496	8	were	be	VBD
cord-015021-pol2qm74	8496	9	discharged	discharge	VBN
cord-015021-pol2qm74	8496	10	from	from	IN
cord-015021-pol2qm74	8496	11	hospital	hospital	NN
cord-015021-pol2qm74	8496	12	.	.	.
cord-015021-pol2qm74	8497	1	10	10	CD
cord-015021-pol2qm74	8497	2	of	of	IN
cord-015021-pol2qm74	8497	3	45	45	CD
cord-015021-pol2qm74	8497	4	non	non	NNS
cord-015021-pol2qm74	8497	5	-	-	NNS
cord-015021-pol2qm74	8497	6	survivors	survivor	NNS
cord-015021-pol2qm74	8497	7	(	(	-LRB-
cord-015021-pol2qm74	8497	8	58	58	CD
cord-015021-pol2qm74	8497	9	%	%	NN
cord-015021-pol2qm74	8497	10	)	)	-RRB-
cord-015021-pol2qm74	8497	11	died	die	VBD
cord-015021-pol2qm74	8497	12	because	because	IN
cord-015021-pol2qm74	8497	13	of	of	IN
cord-015021-pol2qm74	8497	14	fatal	fatal	JJ
cord-015021-pol2qm74	8497	15	MOF	MOF	NNP
cord-015021-pol2qm74	8497	16	within	within	IN
cord-015021-pol2qm74	8497	17	24h	24h	NNS
cord-015021-pol2qm74	8497	18	after	after	IN
cord-015021-pol2qm74	8497	19	admission	admission	NN
cord-015021-pol2qm74	8497	20	to	to	IN
cord-015021-pol2qm74	8497	21	ICU	ICU	NNP
cord-015021-pol2qm74	8497	22	.	.	.
cord-015021-pol2qm74	8498	1	Patients	patient	NNS
cord-015021-pol2qm74	8498	2	with	with	IN
cord-015021-pol2qm74	8498	3	early	early	JJ
cord-015021-pol2qm74	8498	4	application	application	NN
cord-015021-pol2qm74	8498	5	of	of	IN
cord-015021-pol2qm74	8498	6	CVVH	CVVH	NNP
cord-015021-pol2qm74	8498	7	in	in	IN
cord-015021-pol2qm74	8498	8	MOF	MOF	NNP
cord-015021-pol2qm74	8498	9	showed	show	VBD
cord-015021-pol2qm74	8498	10	a	a	DT
cord-015021-pol2qm74	8498	11	better	well	JJR
cord-015021-pol2qm74	8498	12	survival	survival	NN
cord-015021-pol2qm74	8498	13	rate	rate	NN
cord-015021-pol2qm74	8498	14	.	.	.
cord-015021-pol2qm74	8499	1	Mediators	mediator	NNS
cord-015021-pol2qm74	8499	2	of	of	IN
cord-015021-pol2qm74	8499	3	MOF	MOF	NNP
cord-015021-pol2qm74	8499	4	,	,	,
cord-015021-pol2qm74	8499	5	i.e.	i.e.	FW
cord-015021-pol2qm74	8499	6	products	product	NNS
cord-015021-pol2qm74	8499	7	of	of	IN
cord-015021-pol2qm74	8499	8	the	the	DT
cord-015021-pol2qm74	8499	9	complement	complement	NN
cord-015021-pol2qm74	8499	10	cascade	cascade	NN
cord-015021-pol2qm74	8499	11	measured	measure	VBN
cord-015021-pol2qm74	8499	12	in	in	IN
cord-015021-pol2qm74	8499	13	blood	blood	NN
cord-015021-pol2qm74	8499	14	and	and	CC
cord-015021-pol2qm74	8499	15	nitrafiltrate	nitrafiltrate	NN
cord-015021-pol2qm74	8499	16	by	by	IN
cord-015021-pol2qm74	8499	17	ELISA	ELISA	NNP
cord-015021-pol2qm74	8499	18	,	,	,
cord-015021-pol2qm74	8499	19	were	be	VBD
cord-015021-pol2qm74	8499	20	partially	partially	RB
cord-015021-pol2qm74	8499	21	removed	remove	VBN
cord-015021-pol2qm74	8499	22	by	by	IN
cord-015021-pol2qm74	8499	23	CVVH	CVVH	NNP
cord-015021-pol2qm74	8499	24	.	.	.
cord-015021-pol2qm74	8500	1	The	the	DT
cord-015021-pol2qm74	8500	2	testing	testing	NN
cord-015021-pol2qm74	8500	3	ultrafiltrate	ultrafiltrate	NN
cord-015021-pol2qm74	8500	4	by	by	IN
cord-015021-pol2qm74	8500	5	HPLC	HPLC	NNP
cord-015021-pol2qm74	8500	6	demonstrated	demonstrate	VBD
cord-015021-pol2qm74	8500	7	decreasing	decrease	VBG
cord-015021-pol2qm74	8500	8	spikes	spike	NNS
cord-015021-pol2qm74	8500	9	ofpolypeptides	ofpolypeptide	NNS
cord-015021-pol2qm74	8500	10	during	during	IN
cord-015021-pol2qm74	8500	11	hemofiltration	hemofiltration	NN
cord-015021-pol2qm74	8500	12	.	.	.
cord-015021-pol2qm74	8501	1	MOF	MOF	NNP
cord-015021-pol2qm74	8501	2	seems	seem	VBZ
cord-015021-pol2qm74	8501	3	to	to	TO
cord-015021-pol2qm74	8501	4	be	be	VB
cord-015021-pol2qm74	8501	5	generated	generate	VBN
cord-015021-pol2qm74	8501	6	by	by	IN
cord-015021-pol2qm74	8501	7	cascade	cascade	NN
cord-015021-pol2qm74	8501	8	-	-	HYPH
cord-015021-pol2qm74	8501	9	activation	activation	NN
cord-015021-pol2qm74	8501	10	of	of	IN
cord-015021-pol2qm74	8501	11	immune	immune	JJ
cord-015021-pol2qm74	8501	12	competent	competent	JJ
cord-015021-pol2qm74	8501	13	cells	cell	NNS
cord-015021-pol2qm74	8501	14	and	and	CC
cord-015021-pol2qm74	8501	15	plasmatic	plasmatic	JJ
cord-015021-pol2qm74	8501	16	mediators	mediator	NNS
cord-015021-pol2qm74	8501	17	(	(	-LRB-
cord-015021-pol2qm74	8501	18	e.g.	e.g.	NNP
cord-015021-pol2qm74	8501	19	bmdykinin	bmdykinin	NNP
cord-015021-pol2qm74	8501	20	,	,	,
cord-015021-pol2qm74	8501	21	eicosanoides	eicosanoide	NNS
cord-015021-pol2qm74	8501	22	,	,	,
cord-015021-pol2qm74	8501	23	cytokines	cytokine	NNS
cord-015021-pol2qm74	8501	24	,	,	,
cord-015021-pol2qm74	8501	25	anaphylatoxins	anaphylatoxin	NNS
cord-015021-pol2qm74	8501	26	,	,	,
cord-015021-pol2qm74	8501	27	etc	etc	FW
cord-015021-pol2qm74	8501	28	.	.	.
cord-015021-pol2qm74	8501	29	)	)	-RRB-
cord-015021-pol2qm74	8501	30	.	.	.
cord-015021-pol2qm74	8502	1	Therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8502	2	approaches	approach	NNS
cord-015021-pol2qm74	8502	3	aim	aim	VBP
cord-015021-pol2qm74	8502	4	to	to	TO
cord-015021-pol2qm74	8502	5	inactivate	inactivate	VB
cord-015021-pol2qm74	8502	6	or	or	CC
cord-015021-pol2qm74	8502	7	eliminate	eliminate	VB
cord-015021-pol2qm74	8502	8	single	single	JJ
cord-015021-pol2qm74	8502	9	substances	substance	NNS
cord-015021-pol2qm74	8502	10	.	.	.
cord-015021-pol2qm74	8503	1	CWH	cwh	NN
cord-015021-pol2qm74	8503	2	with	with	IN
cord-015021-pol2qm74	8503	3	high	high	JJ
cord-015021-pol2qm74	8503	4	-	-	HYPH
cord-015021-pol2qm74	8503	5	flux	flux	NN
cord-015021-pol2qm74	8503	6	membranes	membrane	NNS
cord-015021-pol2qm74	8503	7	in	in	IN
cord-015021-pol2qm74	8503	8	combination	combination	NN
cord-015021-pol2qm74	8503	9	with	with	IN
cord-015021-pol2qm74	8503	10	high	high	JJ
cord-015021-pol2qm74	8503	11	-	-	HYPH
cord-015021-pol2qm74	8503	12	volume	volume	NN
cord-015021-pol2qm74	8503	13	exchange	exchange	NN
cord-015021-pol2qm74	8503	14	allows	allow	VBZ
cord-015021-pol2qm74	8503	15	elimination	elimination	NN
cord-015021-pol2qm74	8503	16	of	of	IN
cord-015021-pol2qm74	8503	17	many	many	JJ
cord-015021-pol2qm74	8503	18	mediators	mediator	NNS
cord-015021-pol2qm74	8503	19	with	with	IN
cord-015021-pol2qm74	8503	20	different	different	JJ
cord-015021-pol2qm74	8503	21	molecular	molecular	JJ
cord-015021-pol2qm74	8503	22	weight	weight	NN
cord-015021-pol2qm74	8503	23	and	and	CC
cord-015021-pol2qm74	8503	24	therefore	therefore	RB
cord-015021-pol2qm74	8503	25	may	may	MD
cord-015021-pol2qm74	8503	26	contribute	contribute	VB
cord-015021-pol2qm74	8503	27	to	to	TO
cord-015021-pol2qm74	8503	28	improve	improve	VB
cord-015021-pol2qm74	8503	29	the	the	DT
cord-015021-pol2qm74	8503	30	prognosis	prognosis	NN
cord-015021-pol2qm74	8503	31	of	of	IN
cord-015021-pol2qm74	8503	32	MOF	MOF	NNP
cord-015021-pol2qm74	8503	33	.	.	.
cord-015021-pol2qm74	8504	1	Other	other	JJ
cord-015021-pol2qm74	8504	2	significant	significant	JJ
cord-015021-pol2qm74	8504	3	advantages	advantage	NNS
cord-015021-pol2qm74	8504	4	of	of	IN
cord-015021-pol2qm74	8504	5	this	this	DT
cord-015021-pol2qm74	8504	6	teqalnique	teqalnique	NN
cord-015021-pol2qm74	8504	7	like	like	IN
cord-015021-pol2qm74	8504	8	adequate	adequate	JJ
cord-015021-pol2qm74	8504	9	nutrition	nutrition	NN
cord-015021-pol2qm74	8504	10	,	,	,
cord-015021-pol2qm74	8504	11	optimized	optimize	VBN
cord-015021-pol2qm74	8504	12	fluid	fluid	JJ
cord-015021-pol2qm74	8504	13	balance	balance	NN
cord-015021-pol2qm74	8504	14	and	and	CC
cord-015021-pol2qm74	8504	15	control	control	NN
cord-015021-pol2qm74	8504	16	of	of	IN
cord-015021-pol2qm74	8504	17	body	body	NN
cord-015021-pol2qm74	8504	18	temperature	temperature	NN
cord-015021-pol2qm74	8504	19	should	should	MD
cord-015021-pol2qm74	8504	20	not	not	RB
cord-015021-pol2qm74	8504	21	be	be	VB
cord-015021-pol2qm74	8504	22	negicctod	negicctod	NNP
cord-015021-pol2qm74	8504	23	.	.	.
cord-015021-pol2qm74	8505	1	Introductioni	Introductioni	NNP
cord-015021-pol2qm74	8505	2	Pseudomonas	Pseudomonas	NNP
cord-015021-pol2qm74	8505	3	(	(	-LRB-
cord-015021-pol2qm74	8505	4	P	p	NN
cord-015021-pol2qm74	8505	5	)	)	-RRB-
cord-015021-pol2qm74	8505	6	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	8505	7	has	have	VBZ
cord-015021-pol2qm74	8505	8	to	to	TO
cord-015021-pol2qm74	8505	9	be	be	VB
cord-015021-pol2qm74	8505	10	considered	consider	VBN
cord-015021-pol2qm74	8505	11	an	an	DT
cord-015021-pol2qm74	8505	12	important	important	JJ
cord-015021-pol2qm74	8505	13	pathogen	pathogen	NN
cord-015021-pol2qm74	8505	14	of	of	IN
cord-015021-pol2qm74	8505	15	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	8505	16	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8505	17	and	and	CC
cord-015021-pol2qm74	8505	18	septic	septic	JJ
cord-015021-pol2qm74	8505	19	organ	organ	NN
cord-015021-pol2qm74	8505	20	failure	failure	NN
cord-015021-pol2qm74	8505	21	.	.	.
cord-015021-pol2qm74	8506	1	The	the	DT
cord-015021-pol2qm74	8506	2	lung	lung	NN
cord-015021-pol2qm74	8506	3	seems	seem	VBZ
cord-015021-pol2qm74	8506	4	to	to	TO
cord-015021-pol2qm74	8506	5	be	be	VB
cord-015021-pol2qm74	8506	6	the	the	DT
cord-015021-pol2qm74	8506	7	predominant	predominant	JJ
cord-015021-pol2qm74	8506	8	target	target	NN
cord-015021-pol2qm74	8506	9	organ	organ	NN
cord-015021-pol2qm74	8506	10	for	for	IN
cord-015021-pol2qm74	8506	11	the	the	DT
cord-015021-pol2qm74	8506	12	pore	pore	NN
cord-015021-pol2qm74	8506	13	-	-	HYPH
cord-015021-pol2qm74	8506	14	forming	form	VBG
cord-015021-pol2qm74	8506	15	P.	P.	NNP
cord-015021-pol2qm74	8506	16	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	8506	17	cytotoxin	cytotoxin	NN
cord-015021-pol2qm74	8506	18	,	,	,
cord-015021-pol2qm74	8506	19	thus	thus	RB
cord-015021-pol2qm74	8506	20	inducing	induce	VBG
cord-015021-pol2qm74	8506	21	microvascular	microvascular	JJ
cord-015021-pol2qm74	8506	22	injury	injury	NN
cord-015021-pol2qm74	8506	23	.	.	.
cord-015021-pol2qm74	8507	1	With	with	IN
cord-015021-pol2qm74	8507	2	respect	respect	NN
cord-015021-pol2qm74	8507	3	to	to	IN
cord-015021-pol2qm74	8507	4	therapeutical	therapeutical	JJ
cord-015021-pol2qm74	8507	5	consequences	consequence	NNS
cord-015021-pol2qm74	8507	6	,	,	,
cord-015021-pol2qm74	8507	7	the	the	DT
cord-015021-pol2qm74	8507	8	potential	potential	JJ
cord-015021-pol2qm74	8507	9	protective	protective	JJ
cord-015021-pol2qm74	8507	10	effects	effect	NNS
cord-015021-pol2qm74	8507	11	of	of	IN
cord-015021-pol2qm74	8507	12	PAF	PAF	NNP
cord-015021-pol2qm74	8507	13	-	-	HYPH
cord-015021-pol2qm74	8507	14	antagonist	antagonist	NN
cord-015021-pol2qm74	8507	15	(	(	-LRB-
cord-015021-pol2qm74	8507	16	WEB	web	NN
cord-015021-pol2qm74	8507	17	2086	2086	CD
cord-015021-pol2qm74	8507	18	)	)	-RRB-
cord-015021-pol2qm74	8507	19	,	,	,
cord-015021-pol2qm74	8507	20	cyelooxygenase	cyelooxygenase	NNP
cord-015021-pol2qm74	8507	21	inhibitor	inhibitor	NN
cord-015021-pol2qm74	8507	22	(	(	-LRB-
cord-015021-pol2qm74	8507	23	diclofenac	diclofenac	NNP
cord-015021-pol2qm74	8507	24	)	)	-RRB-
cord-015021-pol2qm74	8507	25	and	and	CC
cord-015021-pol2qm74	8507	26	specific	specific	JJ
cord-015021-pol2qm74	8507	27	and	and	CC
cord-015021-pol2qm74	8507	28	unspecific	unspecific	JJ
cord-015021-pol2qm74	8507	29	antibodies	antibody	NNS
cord-015021-pol2qm74	8507	30	on	on	IN
cord-015021-pol2qm74	8507	31	cytotoxin	cytotoxin	NN
cord-015021-pol2qm74	8507	32	-	-	HYPH
cord-015021-pol2qm74	8507	33	induced	induce	VBN
cord-015021-pol2qm74	8507	34	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	8507	35	vascular	vascular	JJ
cord-015021-pol2qm74	8507	36	reaction	reaction	NN
cord-015021-pol2qm74	8507	37	and	and	CC
cord-015021-pol2qm74	8507	38	mediator	mediator	NN
cord-015021-pol2qm74	8507	39	release	release	NN
cord-015021-pol2qm74	8507	40	were	be	VBD
cord-015021-pol2qm74	8507	41	studied	study	VBN
cord-015021-pol2qm74	8507	42	in	in	IN
cord-015021-pol2qm74	8507	43	the	the	DT
cord-015021-pol2qm74	8507	44	isolated	isolate	VBN
cord-015021-pol2qm74	8507	45	perfused	perfuse	VBN
cord-015021-pol2qm74	8507	46	rabbit	rabbit	NN
cord-015021-pol2qm74	8507	47	lung	lung	NN
cord-015021-pol2qm74	8507	48	.	.	.
cord-015021-pol2qm74	8508	1	Methods	method	NNS
cord-015021-pol2qm74	8508	2	:	:	:
cord-015021-pol2qm74	8508	3	Cytotoxin	Cytotoxin	NNP
cord-015021-pol2qm74	8508	4	(	(	-LRB-
cord-015021-pol2qm74	8508	5	6p_g	6p_g	CD
cord-015021-pol2qm74	8508	6	/	/	SYM
cord-015021-pol2qm74	8508	7	ml	ml	NN
cord-015021-pol2qm74	8508	8	)	)	-RRB-
cord-015021-pol2qm74	8508	9	was	be	VBD
cord-015021-pol2qm74	8508	10	administered	administer	VBN
cord-015021-pol2qm74	8508	11	into	into	IN
cord-015021-pol2qm74	8508	12	the	the	DT
cord-015021-pol2qm74	8508	13	perfusion	perfusion	NN
cord-015021-pol2qm74	8508	14	fluid	fluid	NN
cord-015021-pol2qm74	8508	15	in	in	IN
cord-015021-pol2qm74	8508	16	all	all	DT
cord-015021-pol2qm74	8508	17	groups	group	NNS
cord-015021-pol2qm74	8508	18	,	,	,
cord-015021-pol2qm74	8508	19	either	either	CC
cord-015021-pol2qm74	8508	20	in	in	IN
cord-015021-pol2qm74	8508	21	the	the	DT
cord-015021-pol2qm74	8508	22	absence	absence	NN
cord-015021-pol2qm74	8508	23	of	of	IN
cord-015021-pol2qm74	8508	24	inhibitors	inhibitor	NNS
cord-015021-pol2qm74	8508	25	(	(	-LRB-
cord-015021-pol2qm74	8508	26	n=6	n=6	NNP
cord-015021-pol2qm74	8508	27	)	)	-RRB-
cord-015021-pol2qm74	8508	28	,	,	,
cord-015021-pol2qm74	8508	29	or	or	CC
cord-015021-pol2qm74	8508	30	after	after	IN
cord-015021-pol2qm74	8508	31	pretreatment	pretreatment	NN
cord-015021-pol2qm74	8508	32	with	with	IN
cord-015021-pol2qm74	8508	33	WEB	web	NN
cord-015021-pol2qm74	8508	34	2086	2086	CD
cord-015021-pol2qm74	8508	35	(	(	-LRB-
cord-015021-pol2qm74	8508	36	5xl0-gM	5xl0-gm	CD
cord-015021-pol2qm74	8508	37	,	,	,
cord-015021-pol2qm74	8508	38	n=6	n=6	NNP
cord-015021-pol2qm74	8508	39	)	)	-RRB-
cord-015021-pol2qm74	8508	40	,	,	,
cord-015021-pol2qm74	8508	41	or	or	CC
cord-015021-pol2qm74	8508	42	diclofenac	diclofenac	NNP
cord-015021-pol2qm74	8508	43	(	(	-LRB-
cord-015021-pol2qm74	8508	44	10#g	10#g	NNP
cord-015021-pol2qm74	8508	45	/	/	SYM
cord-015021-pol2qm74	8508	46	ml	ml	NN
cord-015021-pol2qm74	8508	47	,	,	,
cord-015021-pol2qm74	8508	48	n-6	n-6	NNP
cord-015021-pol2qm74	8508	49	)	)	-RRB-
cord-015021-pol2qm74	8508	50	.	.	.
cord-015021-pol2qm74	8509	1	Furthermore	furthermore	RB
cord-015021-pol2qm74	8509	2	,	,	,
cord-015021-pol2qm74	8509	3	the	the	DT
cord-015021-pol2qm74	8509	4	application	application	NN
cord-015021-pol2qm74	8509	5	of	of	IN
cord-015021-pol2qm74	8509	6	specific	specific	JJ
cord-015021-pol2qm74	8509	7	antitoxin	antitoxin	NN
cord-015021-pol2qm74	8509	8	(	(	-LRB-
cord-015021-pol2qm74	8509	9	mg	mg	NNP
cord-015021-pol2qm74	8509	10	/	/	SYM
cord-015021-pol2qm74	8509	11	ml	ml	NNP
cord-015021-pol2qm74	8509	12	,	,	,
cord-015021-pol2qm74	8509	13	n=6	n=6	NNP
cord-015021-pol2qm74	8509	14	)	)	-RRB-
cord-015021-pol2qm74	8509	15	was	be	VBD
cord-015021-pol2qm74	8509	16	tested	test	VBN
cord-015021-pol2qm74	8509	17	in	in	IN
cord-015021-pol2qm74	8509	18	comparison	comparison	NN
cord-015021-pol2qm74	8509	19	with	with	IN
cord-015021-pol2qm74	8509	20	the	the	DT
cord-015021-pol2qm74	8509	21	unspecific	unspecific	JJ
cord-015021-pol2qm74	8509	22	immunoglobulins	immunoglobulin	NNS
cord-015021-pol2qm74	8509	23	(	(	-LRB-
cord-015021-pol2qm74	8509	24	Venimmun	Venimmun	NNP
cord-015021-pol2qm74	8509	25	®	®	POS
cord-015021-pol2qm74	8509	26	,	,	,
cord-015021-pol2qm74	8509	27	Behring	Behring	NNP
cord-015021-pol2qm74	8509	28	,	,	,
cord-015021-pol2qm74	8509	29	7.5	7.5	CD
cord-015021-pol2qm74	8509	30	mg	mg	NNP
cord-015021-pol2qm74	8509	31	/	/	SYM
cord-015021-pol2qm74	8509	32	ml	ml	NN
cord-015021-pol2qm74	8509	33	)	)	-RRB-
cord-015021-pol2qm74	8509	34	(	(	-LRB-
cord-015021-pol2qm74	8509	35	n=6	n=6	NNP
cord-015021-pol2qm74	8509	36	)	)	-RRB-
cord-015021-pol2qm74	8509	37	and	and	CC
cord-015021-pol2qm74	8509	38	the	the	DT
cord-015021-pol2qm74	8509	39	combination	combination	NN
cord-015021-pol2qm74	8509	40	of	of	IN
cord-015021-pol2qm74	8509	41	immunogiobulins	immunogiobulin	NNS
cord-015021-pol2qm74	8509	42	,	,	,
cord-015021-pol2qm74	8509	43	WEB	web	NN
cord-015021-pol2qm74	8509	44	2086	2086	CD
cord-015021-pol2qm74	8509	45	and	and	CC
cord-015021-pol2qm74	8509	46	diclofenac	diclofenac	NNP
cord-015021-pol2qm74	8509	47	(	(	-LRB-
cord-015021-pol2qm74	8509	48	n=6	n=6	NNP
cord-015021-pol2qm74	8509	49	)	)	-RRB-
cord-015021-pol2qm74	8509	50	.	.	.
cord-015021-pol2qm74	8510	1	Six	six	CD
cord-015021-pol2qm74	8510	2	experiments	experiment	NNS
cord-015021-pol2qm74	8510	3	without	without	IN
cord-015021-pol2qm74	8510	4	toxin	toxin	NN
cord-015021-pol2qm74	8510	5	served	serve	VBD
cord-015021-pol2qm74	8510	6	as	as	IN
cord-015021-pol2qm74	8510	7	controls	control	NNS
cord-015021-pol2qm74	8510	8	.	.	.
cord-015021-pol2qm74	8511	1	The	the	DT
cord-015021-pol2qm74	8511	2	arterial	arterial	JJ
cord-015021-pol2qm74	8511	3	pressure	pressure	NN
cord-015021-pol2qm74	8511	4	mad	mad	VBP
cord-015021-pol2qm74	8511	5	the	the	DT
cord-015021-pol2qm74	8511	6	weight	weight	NN
cord-015021-pol2qm74	8511	7	gain	gain	NN
cord-015021-pol2qm74	8511	8	as	as	IN
cord-015021-pol2qm74	8511	9	an	an	DT
cord-015021-pol2qm74	8511	10	indicator	indicator	NN
cord-015021-pol2qm74	8511	11	of	of	IN
cord-015021-pol2qm74	8511	12	edema	edema	NN
cord-015021-pol2qm74	8511	13	formation	formation	NN
cord-015021-pol2qm74	8511	14	were	be	VBD
cord-015021-pol2qm74	8511	15	continuously	continuously	RB
cord-015021-pol2qm74	8511	16	monitored	monitor	VBN
cord-015021-pol2qm74	8511	17	during	during	IN
cord-015021-pol2qm74	8511	18	the	the	DT
cord-015021-pol2qm74	8511	19	three	three	CD
cord-015021-pol2qm74	8511	20	hour	hour	NN
cord-015021-pol2qm74	8511	21	peffusion	peffusion	NN
cord-015021-pol2qm74	8511	22	phase	phase	NN
cord-015021-pol2qm74	8511	23	.	.	.
cord-015021-pol2qm74	8512	1	Arachidonic	arachidonic	JJ
cord-015021-pol2qm74	8512	2	-	-	HYPH
cord-015021-pol2qm74	8512	3	ucid	ucid	JJ
cord-015021-pol2qm74	8512	4	metabolites	metabolite	NNS
cord-015021-pol2qm74	8512	5	,	,	,
cord-015021-pol2qm74	8512	6	as	as	RB
cord-015021-pol2qm74	8512	7	well	well	RB
cord-015021-pol2qm74	8512	8	as	as	IN
cord-015021-pol2qm74	8512	9	lactate	lactate	NN
cord-015021-pol2qm74	8512	10	dehydrogenase	dehydrogenase	NN
cord-015021-pol2qm74	8512	11	(	(	-LRB-
cord-015021-pol2qm74	8512	12	LDH	LDH	NNP
cord-015021-pol2qm74	8512	13	)	)	-RRB-
cord-015021-pol2qm74	8512	14	and	and	CC
cord-015021-pol2qm74	8512	15	K	K	NNP
cord-015021-pol2qm74	8512	16	+	+	CC
cord-015021-pol2qm74	8512	17	concentrations	concentration	NNS
cord-015021-pol2qm74	8512	18	were	be	VBD
cord-015021-pol2qm74	8512	19	determined	determine	VBN
cord-015021-pol2qm74	8512	20	at	at	IN
cord-015021-pol2qm74	8512	21	30	30	CD
cord-015021-pol2qm74	8512	22	rain	rain	NN
cord-015021-pol2qm74	8512	23	intervals	interval	NNS
cord-015021-pol2qm74	8512	24	.	.	.
cord-015021-pol2qm74	8513	1	Results	result	NNS
cord-015021-pol2qm74	8513	2	:	:	:
cord-015021-pol2qm74	8514	1	Cytotoxin	Cytotoxin	NNP
cord-015021-pol2qm74	8514	2	caused	cause	VBD
cord-015021-pol2qm74	8514	3	a	a	DT
cord-015021-pol2qm74	8514	4	gradual	gradual	JJ
cord-015021-pol2qm74	8514	5	increase	increase	NN
cord-015021-pol2qm74	8514	6	in	in	IN
cord-015021-pol2qm74	8514	7	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	8514	8	arterial	arterial	JJ
cord-015021-pol2qm74	8514	9	pressure	pressure	NN
cord-015021-pol2qm74	8514	10	,	,	,
cord-015021-pol2qm74	8514	11	reaching	reach	VBG
cord-015021-pol2qm74	8514	12	a	a	DT
cord-015021-pol2qm74	8514	13	maximum	maximum	JJ
cord-015021-pol2qm74	8514	14	value	value	NN
cord-015021-pol2qm74	8514	15	of	of	IN
cord-015021-pol2qm74	8514	16	2.5	2.5	CD
cord-015021-pol2qm74	8514	17	times	time	NNS
cord-015021-pol2qm74	8514	18	higher	high	JJR
cord-015021-pol2qm74	8514	19	than	than	IN
cord-015021-pol2qm74	8514	20	the	the	DT
cord-015021-pol2qm74	8514	21	control	control	NN
cord-015021-pol2qm74	8514	22	,	,	,
cord-015021-pol2qm74	8514	23	starting	start	VBG
cord-015021-pol2qm74	8514	24	after	after	IN
cord-015021-pol2qm74	8514	25	1	1	CD
cord-015021-pol2qm74	8514	26	min	min	NN
cord-015021-pol2qm74	8514	27	and	and	CC
cord-015021-pol2qm74	8514	28	a	a	DT
cord-015021-pol2qm74	8514	29	delayed	delay	VBN
cord-015021-pol2qm74	8514	30	onset	onset	NN
cord-015021-pol2qm74	8514	31	of	of	IN
cord-015021-pol2qm74	8514	32	edema	edema	NN
cord-015021-pol2qm74	8514	33	formation	formation	NN
cord-015021-pol2qm74	8514	34	resulting	result	VBG
cord-015021-pol2qm74	8514	35	in	in	IN
cord-015021-pol2qm74	8514	36	a	a	DT
cord-015021-pol2qm74	8514	37	mean	mean	JJ
cord-015021-pol2qm74	8514	38	weight	weight	NN
cord-015021-pol2qm74	8514	39	gain	gain	NN
cord-015021-pol2qm74	8514	40	of	of	IN
cord-015021-pol2qm74	8514	41	20	20	CD
cord-015021-pol2qm74	8514	42	g	g	NN
cord-015021-pol2qm74	8514	43	after	after	IN
cord-015021-pol2qm74	8514	44	120	120	CD
cord-015021-pol2qm74	8514	45	min	min	NN
cord-015021-pol2qm74	8514	46	.	.	.
cord-015021-pol2qm74	8515	1	This	this	DT
cord-015021-pol2qm74	8515	2	was	be	VBD
cord-015021-pol2qm74	8515	3	paralleled	parallel	VBN
cord-015021-pol2qm74	8515	4	by	by	IN
cord-015021-pol2qm74	8515	5	a	a	DT
cord-015021-pol2qm74	8515	6	significant	significant	JJ
cord-015021-pol2qm74	8515	7	increase	increase	NN
cord-015021-pol2qm74	8515	8	in	in	IN
cord-015021-pol2qm74	8515	9	prostacyclin	prostacyclin	JJ
cord-015021-pol2qm74	8515	10	generation	generation	NN
cord-015021-pol2qm74	8515	11	and	and	CC
cord-015021-pol2qm74	8515	12	a	a	DT
cord-015021-pol2qm74	8515	13	continuous	continuous	JJ
cord-015021-pol2qm74	8515	14	release	release	NN
cord-015021-pol2qm74	8515	15	of	of	IN
cord-015021-pol2qm74	8515	16	K	k	NN
cord-015021-pol2qm74	8515	17	+	+	CC
cord-015021-pol2qm74	8515	18	and	and	CC
cord-015021-pol2qm74	8515	19	LDH	LDH	NNP
cord-015021-pol2qm74	8515	20	.	.	.
cord-015021-pol2qm74	8516	1	Thromboxane	Thromboxane	NNP
cord-015021-pol2qm74	8516	2	synthesis	synthesis	NN
cord-015021-pol2qm74	8516	3	exceeded	exceed	VBD
cord-015021-pol2qm74	8516	4	about	about	RB
cord-015021-pol2qm74	8516	5	10	10	CD
cord-015021-pol2qm74	8516	6	times	time	NNS
cord-015021-pol2qm74	8516	7	that	that	DT
cord-015021-pol2qm74	8516	8	of	of	IN
cord-015021-pol2qm74	8516	9	controls	control	NNS
cord-015021-pol2qm74	8516	10	in	in	IN
cord-015021-pol2qm74	8516	11	the	the	DT
cord-015021-pol2qm74	8516	12	toxin	toxin	NN
cord-015021-pol2qm74	8516	13	treated	treat	VBD
cord-015021-pol2qm74	8516	14	lungs	lung	NNS
cord-015021-pol2qm74	8516	15	.	.	.
cord-015021-pol2qm74	8517	1	Pretreatment	pretreatment	NN
cord-015021-pol2qm74	8517	2	with	with	IN
cord-015021-pol2qm74	8517	3	WEB	web	NN
cord-015021-pol2qm74	8517	4	2086	2086	CD
cord-015021-pol2qm74	8517	5	or	or	CC
cord-015021-pol2qm74	8517	6	diclofenac	diclofenac	NN
cord-015021-pol2qm74	8517	7	significantly	significantly	RB
cord-015021-pol2qm74	8517	8	attenuated	attenuate	VBD
cord-015021-pol2qm74	8517	9	the	the	DT
cord-015021-pol2qm74	8517	10	pressure	pressure	NN
cord-015021-pol2qm74	8517	11	response	response	NN
cord-015021-pol2qm74	8517	12	and	and	CC
cord-015021-pol2qm74	8517	13	edema	edema	NN
cord-015021-pol2qm74	8517	14	formation	formation	NN
cord-015021-pol2qm74	8517	15	evoked	evoke	VBN
cord-015021-pol2qm74	8517	16	by	by	IN
cord-015021-pol2qm74	8517	17	cytotoxin	cytotoxin	NNP
cord-015021-pol2qm74	8517	18	.	.	.
cord-015021-pol2qm74	8518	1	The	the	DT
cord-015021-pol2qm74	8518	2	addition	addition	NN
cord-015021-pol2qm74	8518	3	of	of	IN
cord-015021-pol2qm74	8518	4	the	the	DT
cord-015021-pol2qm74	8518	5	unspecific	unspecific	JJ
cord-015021-pol2qm74	8518	6	immunognbulin	immunognbulin	JJ
cord-015021-pol2qm74	8518	7	preparation	preparation	NN
cord-015021-pol2qm74	8518	8	alone	alone	RB
cord-015021-pol2qm74	8518	9	induced	induce	VBD
cord-015021-pol2qm74	8518	10	a	a	DT
cord-015021-pol2qm74	8518	11	transient	transient	JJ
cord-015021-pol2qm74	8518	12	pressure	pressure	NN
cord-015021-pol2qm74	8518	13	increase	increase	NN
cord-015021-pol2qm74	8518	14	within	within	IN
cord-015021-pol2qm74	8518	15	the	the	DT
cord-015021-pol2qm74	8518	16	first	first	JJ
cord-015021-pol2qm74	8518	17	minutes	minute	NNS
cord-015021-pol2qm74	8518	18	,	,	,
cord-015021-pol2qm74	8518	19	but	but	CC
cord-015021-pol2qm74	8518	20	mean	mean	JJ
cord-015021-pol2qm74	8518	21	values	value	NNS
cord-015021-pol2qm74	8518	22	remained	remain	VBD
cord-015021-pol2qm74	8518	23	below	below	IN
cord-015021-pol2qm74	8518	24	those	those	DT
cord-015021-pol2qm74	8518	25	of	of	IN
cord-015021-pol2qm74	8518	26	the	the	DT
cord-015021-pol2qm74	8518	27	cytotoxin	cytotoxin	NNP
cord-015021-pol2qm74	8518	28	group	group	NN
cord-015021-pol2qm74	8518	29	in	in	IN
cord-015021-pol2qm74	8518	30	the	the	DT
cord-015021-pol2qm74	8518	31	continuing	continue	VBG
cord-015021-pol2qm74	8518	32	observation	observation	NN
cord-015021-pol2qm74	8518	33	period	period	NN
cord-015021-pol2qm74	8518	34	.	.	.
cord-015021-pol2qm74	8519	1	Mmost	Mmost	NNP
cord-015021-pol2qm74	8519	2	complete	complete	JJ
cord-015021-pol2qm74	8519	3	inhibition	inhibition	NN
cord-015021-pol2qm74	8519	4	of	of	IN
cord-015021-pol2qm74	8519	5	the	the	DT
cord-015021-pol2qm74	8519	6	pressure	pressure	NN
cord-015021-pol2qm74	8519	7	reaction	reaction	NN
cord-015021-pol2qm74	8519	8	,	,	,
cord-015021-pol2qm74	8519	9	the	the	DT
cord-015021-pol2qm74	8519	10	edema	edema	NN
cord-015021-pol2qm74	8519	11	formation	formation	NN
cord-015021-pol2qm74	8519	12	and	and	CC
cord-015021-pol2qm74	8519	13	the	the	DT
cord-015021-pol2qm74	8519	14	metabolic	metabolic	JJ
cord-015021-pol2qm74	8519	15	alterations	alteration	NNS
cord-015021-pol2qm74	8519	16	was	be	VBD
cord-015021-pol2qm74	8519	17	achieved	achieve	VBN
cord-015021-pol2qm74	8519	18	mainly	mainly	RB
cord-015021-pol2qm74	8519	19	by	by	IN
cord-015021-pol2qm74	8519	20	the	the	DT
cord-015021-pol2qm74	8519	21	combination	combination	NN
cord-015021-pol2qm74	8519	22	of	of	IN
cord-015021-pol2qm74	8519	23	immunoglobulin	immunoglobulin	NN
cord-015021-pol2qm74	8519	24	,	,	,
cord-015021-pol2qm74	8519	25	WEB	web	NN
cord-015021-pol2qm74	8519	26	2086	2086	CD
cord-015021-pol2qm74	8519	27	and	and	CC
cord-015021-pol2qm74	8519	28	diclofenac	diclofenac	NN
cord-015021-pol2qm74	8519	29	and	and	CC
cord-015021-pol2qm74	8519	30	to	to	IN
cord-015021-pol2qm74	8519	31	lesser	less	JJR
cord-015021-pol2qm74	8519	32	extend	extend	VB
cord-015021-pol2qm74	8519	33	by	by	IN
cord-015021-pol2qm74	8519	34	the	the	DT
cord-015021-pol2qm74	8519	35	specific	specific	JJ
cord-015021-pol2qm74	8519	36	toxin	toxin	NN
cord-015021-pol2qm74	8519	37	antibody	antibody	NN
cord-015021-pol2qm74	8519	38	.	.	.
cord-015021-pol2qm74	8520	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	8520	2	:	:	:
cord-015021-pol2qm74	8521	1	The	the	DT
cord-015021-pol2qm74	8521	2	current	current	JJ
cord-015021-pol2qm74	8521	3	results	result	NNS
cord-015021-pol2qm74	8521	4	point	point	NN
cord-015021-pol2qm74	8521	5	towards	towards	IN
cord-015021-pol2qm74	8521	6	the	the	DT
cord-015021-pol2qm74	8521	7	crucial	crucial	JJ
cord-015021-pol2qm74	8521	8	role	role	NN
cord-015021-pol2qm74	8521	9	of	of	IN
cord-015021-pol2qm74	8521	10	PAF	PAF	NNP
cord-015021-pol2qm74	8521	11	and	and	CC
cord-015021-pol2qm74	8521	12	AA	AA	NNP
cord-015021-pol2qm74	8521	13	-	-	HYPH
cord-015021-pol2qm74	8521	14	metabolites	metabolite	NNS
cord-015021-pol2qm74	8521	15	as	as	IN
cord-015021-pol2qm74	8521	16	mediators	mediator	NNS
cord-015021-pol2qm74	8521	17	of	of	IN
cord-015021-pol2qm74	8521	18	cytotoxin	cytotoxin	NNP
cord-015021-pol2qm74	8521	19	induced	induce	VBD
cord-015021-pol2qm74	8521	20	microvascular	microvascular	JJ
cord-015021-pol2qm74	8521	21	injury	injury	NN
cord-015021-pol2qm74	8521	22	.	.	.
cord-015021-pol2qm74	8522	1	The	the	DT
cord-015021-pol2qm74	8522	2	systemic	systemic	JJ
cord-015021-pol2qm74	8522	3	or	or	CC
cord-015021-pol2qm74	8522	4	local	local	JJ
cord-015021-pol2qm74	8522	5	application	application	NN
cord-015021-pol2qm74	8522	6	of	of	IN
cord-015021-pol2qm74	8522	7	cytotoxin	cytotoxin	NNP
cord-015021-pol2qm74	8522	8	antibodies	antibody	NNS
cord-015021-pol2qm74	8522	9	or	or	CC
cord-015021-pol2qm74	8522	10	even	even	RB
cord-015021-pol2qm74	8522	11	unspecific	unspecific	JJ
cord-015021-pol2qm74	8522	12	immunoglobolins	immunoglobolin	NNS
cord-015021-pol2qm74	8522	13	in	in	IN
cord-015021-pol2qm74	8522	14	combination	combination	NN
cord-015021-pol2qm74	8522	15	with	with	IN
cord-015021-pol2qm74	8522	16	PAF	PAF	NNP
cord-015021-pol2qm74	8522	17	-	-	HYPH
cord-015021-pol2qm74	8522	18	antagonist	antagonist	NN
cord-015021-pol2qm74	8522	19	and	and	CC
cord-015021-pol2qm74	8522	20	diclofenac	diclofenac	NN
cord-015021-pol2qm74	8522	21	appears	appear	VBZ
cord-015021-pol2qm74	8522	22	to	to	TO
cord-015021-pol2qm74	8522	23	be	be	VB
cord-015021-pol2qm74	8522	24	a	a	DT
cord-015021-pol2qm74	8522	25	promising	promising	JJ
cord-015021-pol2qm74	8522	26	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8522	27	approach	approach	NN
cord-015021-pol2qm74	8522	28	in	in	IN
cord-015021-pol2qm74	8522	29	the	the	DT
cord-015021-pol2qm74	8522	30	case	case	NN
cord-015021-pol2qm74	8522	31	of	of	IN
cord-015021-pol2qm74	8522	32	infection	infection	NN
cord-015021-pol2qm74	8522	33	with	with	IN
cord-015021-pol2qm74	8522	34	cytotoxin	cytotoxin	NN
cord-015021-pol2qm74	8522	35	-	-	HYPH
cord-015021-pol2qm74	8522	36	preducing	preduce	VBG
cord-015021-pol2qm74	8522	37	strains	strain	NNS
cord-015021-pol2qm74	8522	38	.	.	.
cord-015021-pol2qm74	8523	1	Cytokines	cytokine	NNS
cord-015021-pol2qm74	8523	2	have	have	VBP
cord-015021-pol2qm74	8523	3	long	long	RB
cord-015021-pol2qm74	8523	4	been	be	VBN
cord-015021-pol2qm74	8523	5	shown	show	VBN
cord-015021-pol2qm74	8523	6	to	to	TO
cord-015021-pol2qm74	8523	7	be	be	VB
cord-015021-pol2qm74	8523	8	of	of	IN
cord-015021-pol2qm74	8523	9	particular	particular	JJ
cord-015021-pol2qm74	8523	10	importance	importance	NN
cord-015021-pol2qm74	8523	11	in	in	IN
cord-015021-pol2qm74	8523	12	the	the	DT
cord-015021-pol2qm74	8523	13	metabolic	metabolic	JJ
cord-015021-pol2qm74	8523	14	derangements	derangement	NNS
cord-015021-pol2qm74	8523	15	occurring	occur	VBG
cord-015021-pol2qm74	8523	16	in	in	IN
cord-015021-pol2qm74	8523	17	LPS	LPS	NNP
cord-015021-pol2qm74	8523	18	-	-	HYPH
cord-015021-pol2qm74	8523	19	induced	induce	VBN
cord-015021-pol2qm74	8523	20	shock	shock	NN
cord-015021-pol2qm74	8523	21	.	.	.
cord-015021-pol2qm74	8524	1	Recent	recent	JJ
cord-015021-pol2qm74	8524	2	studies	study	NNS
cord-015021-pol2qm74	8524	3	strongly	strongly	RB
cord-015021-pol2qm74	8524	4	imply	imply	VBP
cord-015021-pol2qm74	8524	5	the	the	DT
cord-015021-pol2qm74	8524	6	involvement	involvement	NN
cord-015021-pol2qm74	8524	7	of	of	IN
cord-015021-pol2qm74	8524	8	Platelet	platelet	NN
cord-015021-pol2qm74	8524	9	Aggregating	Aggregating	NNP
cord-015021-pol2qm74	8524	10	Factor	Factor	NNP
cord-015021-pol2qm74	8524	11	(	(	-LRB-
cord-015021-pol2qm74	8524	12	PAF	PAF	NNP
cord-015021-pol2qm74	8524	13	)	)	-RRB-
cord-015021-pol2qm74	8524	14	in	in	IN
cord-015021-pol2qm74	8524	15	the	the	DT
cord-015021-pol2qm74	8524	16	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8524	17	of	of	IN
cord-015021-pol2qm74	8524	18	Gram	gram	NN
cord-015021-pol2qm74	8524	19	-	-	HYPH
cord-015021-pol2qm74	8524	20	negative	negative	JJ
cord-015021-pol2qm74	8524	21	bacterial	bacterial	JJ
cord-015021-pol2qm74	8524	22	sepsis	sepsis	NN
cord-015021-pol2qm74	8524	23	.	.	.
cord-015021-pol2qm74	8525	1	An	an	DT
cord-015021-pol2qm74	8525	2	autocatalytic	autocatalytic	JJ
cord-015021-pol2qm74	8525	3	feedback	feedback	NN
cord-015021-pol2qm74	8525	4	network	network	NN
cord-015021-pol2qm74	8525	5	has	have	VBZ
cord-015021-pol2qm74	8525	6	been	be	VBN
cord-015021-pol2qm74	8525	7	postulated	postulate	VBN
cord-015021-pol2qm74	8525	8	to	to	TO
cord-015021-pol2qm74	8525	9	exist	exist	VB
cord-015021-pol2qm74	8525	10	between	between	IN
cord-015021-pol2qm74	8525	11	PAF	PAF	NNP
cord-015021-pol2qm74	8525	12	and	and	CC
cord-015021-pol2qm74	8525	13	Tumor	Tumor	NNP
cord-015021-pol2qm74	8525	14	Necrosis	necrosis	NN
cord-015021-pol2qm74	8525	15	Factor	factor	NN
cord-015021-pol2qm74	8525	16	(	(	-LRB-
cord-015021-pol2qm74	8525	17	TNF	TNF	NNP
cord-015021-pol2qm74	8525	18	)	)	-RRB-
cord-015021-pol2qm74	8525	19	,	,	,
cord-015021-pol2qm74	8525	20	a	a	DT
cord-015021-pol2qm74	8525	21	key	key	JJ
cord-015021-pol2qm74	8525	22	cytokine	cytokine	NN
cord-015021-pol2qm74	8525	23	involved	involve	VBN
cord-015021-pol2qm74	8525	24	in	in	IN
cord-015021-pol2qm74	8525	25	septic	septic	JJ
cord-015021-pol2qm74	8525	26	metabolic	metabolic	JJ
cord-015021-pol2qm74	8525	27	cascade	cascade	NN
cord-015021-pol2qm74	8525	28	,	,	,
cord-015021-pol2qm74	8525	29	leading	lead	VBG
cord-015021-pol2qm74	8525	30	to	to	IN
cord-015021-pol2qm74	8525	31	an	an	DT
cord-015021-pol2qm74	8525	32	uncontrolled	uncontrolled	JJ
cord-015021-pol2qm74	8525	33	amplification	amplification	NN
cord-015021-pol2qm74	8525	34	of	of	IN
cord-015021-pol2qm74	8525	35	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8525	36	mediator	mediator	NN
cord-015021-pol2qm74	8525	37	release	release	NN
cord-015021-pol2qm74	8525	38	.	.	.
cord-015021-pol2qm74	8526	1	We	-PRON-	PRP
cord-015021-pol2qm74	8526	2	have	have	VBP
cord-015021-pol2qm74	8526	3	previously	previously	RB
cord-015021-pol2qm74	8526	4	shown	show	VBN
cord-015021-pol2qm74	8526	5	that	that	IN
cord-015021-pol2qm74	8526	6	ST	ST	NNP
cord-015021-pol2qm74	8526	7	899	899	CD
cord-015021-pol2qm74	8527	1	(	(	-LRB-
cord-015021-pol2qm74	8527	2	4-N	4-n	CD
cord-015021-pol2qm74	8527	3	,	,	,
cord-015021-pol2qm74	8527	4	N	n	CD
cord-015021-pol2qm74	8527	5	,	,	,
cord-015021-pol2qm74	8527	6	N	N	NNP
cord-015021-pol2qm74	8527	7	trimethylammonium-(R)-3-isovaleroyloxy	trimethylammonium-(R)-3-isovaleroyloxy	NNP
cord-015021-pol2qm74	8527	8	-	-	HYPH
cord-015021-pol2qm74	8527	9	butanoic	butanoic	NNP
cord-015021-pol2qm74	8527	10	acid	acid	NNP
cord-015021-pol2qm74	8527	11	Z-3-(5-chlorphtalidiliden	Z-3-(5-chlorphtalidiliden	NNP
cord-015021-pol2qm74	8527	12	)	)	-RRB-
cord-015021-pol2qm74	8528	1	ethyl	ethyl	NNP
cord-015021-pol2qm74	8528	2	ester	ester	NNP
cord-015021-pol2qm74	8528	3	bromide	bromide	NN
cord-015021-pol2qm74	8528	4	)	)	-RRB-
cord-015021-pol2qm74	8528	5	was	be	VBD
cord-015021-pol2qm74	8528	6	quite	quite	RB
cord-015021-pol2qm74	8528	7	effective	effective	JJ
cord-015021-pol2qm74	8528	8	in	in	IN
cord-015021-pol2qm74	8528	9	inhibiting	inhibit	VBG
cord-015021-pol2qm74	8528	10	the	the	DT
cord-015021-pol2qm74	8528	11	"	"	``
cord-015021-pol2qm74	8528	12	in	in	FW
cord-015021-pol2qm74	8528	13	vitro	vitro	FW
cord-015021-pol2qm74	8528	14	"	"	''
cord-015021-pol2qm74	8528	15	binding	bind	VBG
cord-015021-pol2qm74	8528	16	of	of	IN
cord-015021-pol2qm74	8528	17	3H	3h	CD
cord-015021-pol2qm74	8528	18	-	-	HYPH
cord-015021-pol2qm74	8528	19	PAF	PAF	NNP
cord-015021-pol2qm74	8528	20	(	(	-LRB-
cord-015021-pol2qm74	8528	21	Ki=7.5x10	Ki=7.5x10	NNP
cord-015021-pol2qm74	8528	22	-8	-8	NNP
cord-015021-pol2qm74	8528	23	M	M	NNP
cord-015021-pol2qm74	8528	24	)	)	-RRB-
cord-015021-pol2qm74	8528	25	to	to	IN
cord-015021-pol2qm74	8528	26	rabbit	rabbit	NN
cord-015021-pol2qm74	8528	27	platelets	platelet	NNS
cord-015021-pol2qm74	8528	28	.	.	.
cord-015021-pol2qm74	8529	1	The	the	DT
cord-015021-pol2qm74	8529	2	present	present	JJ
cord-015021-pol2qm74	8529	3	study	study	NN
cord-015021-pol2qm74	8529	4	shows	show	VBZ
cord-015021-pol2qm74	8529	5	that	that	IN
cord-015021-pol2qm74	8529	6	pretreatment	pretreatment	NN
cord-015021-pol2qm74	8529	7	of	of	IN
cord-015021-pol2qm74	8529	8	C57BL/6	C57BL/6	NNP
cord-015021-pol2qm74	8529	9	mice	mouse	NNS
cord-015021-pol2qm74	8529	10	with	with	IN
cord-015021-pol2qm74	8529	11	ST	ST	NNP
cord-015021-pol2qm74	8529	12	899	899	CD
cord-015021-pol2qm74	8529	13	,	,	,
cord-015021-pol2qm74	8529	14	administered	administer	VBN
cord-015021-pol2qm74	8529	15	by	by	IN
cord-015021-pol2qm74	8529	16	different	different	JJ
cord-015021-pol2qm74	8529	17	routes	route	NNS
cord-015021-pol2qm74	8529	18	,	,	,
cord-015021-pol2qm74	8529	19	dose	dose	NN
cord-015021-pol2qm74	8529	20	-	-	HYPH
cord-015021-pol2qm74	8529	21	dependently	dependently	RB
cord-015021-pol2qm74	8529	22	and	and	CC
cord-015021-pol2qm74	8529	23	significantly	significantly	RB
cord-015021-pol2qm74	8529	24	reduces	reduce	VBZ
cord-015021-pol2qm74	8529	25	the	the	DT
cord-015021-pol2qm74	8529	26	lethality	lethality	NN
cord-015021-pol2qm74	8529	27	induced	induce	VBN
cord-015021-pol2qm74	8529	28	by	by	IN
cord-015021-pol2qm74	8529	29	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8529	30	(	(	-LRB-
cord-015021-pol2qm74	8529	31	E.coli	E.coli	NNS
cord-015021-pol2qm74	8529	32	055	055	CD
cord-015021-pol2qm74	8529	33	:	:	:
cord-015021-pol2qm74	8529	34	B5	b5	NN
cord-015021-pol2qm74	8529	35	injected	inject	VBD
cord-015021-pol2qm74	8529	36	at	at	IN
cord-015021-pol2qm74	8529	37	30	30	CD
cord-015021-pol2qm74	8529	38	mg	mg	NN
cord-015021-pol2qm74	8529	39	/	/	SYM
cord-015021-pol2qm74	8529	40	kg	kg	NNP
cord-015021-pol2qm74	8529	41	intraperitoneally	intraperitoneally	NN
cord-015021-pol2qm74	8529	42	)	)	-RRB-
cord-015021-pol2qm74	8529	43	.	.	.
cord-015021-pol2qm74	8530	1	Very	very	RB
cord-015021-pol2qm74	8530	2	interestingly	interestingly	RB
cord-015021-pol2qm74	8530	3	,	,	,
cord-015021-pol2qm74	8530	4	ST	ST	NNP
cord-015021-pol2qm74	8530	5	899	899	CD
cord-015021-pol2qm74	8530	6	administered	administer	VBD
cord-015021-pol2qm74	8530	7	at	at	IN
cord-015021-pol2qm74	8530	8	the	the	DT
cord-015021-pol2qm74	8530	9	same	same	JJ
cord-015021-pol2qm74	8530	10	doses	dose	NNS
cord-015021-pol2qm74	8530	11	as	as	IN
cord-015021-pol2qm74	8530	12	above	above	RB
cord-015021-pol2qm74	8530	13	(	(	-LRB-
cord-015021-pol2qm74	8530	14	i.e.	i.e.	FW
cord-015021-pol2qm74	8530	15	1.25	1.25	CD
cord-015021-pol2qm74	8530	16	,	,	,
cord-015021-pol2qm74	8530	17	2.5	2.5	CD
cord-015021-pol2qm74	8530	18	,	,	,
cord-015021-pol2qm74	8530	19	and	and	CC
cord-015021-pol2qm74	8530	20	5	5	CD
cord-015021-pol2qm74	8530	21	mg	mg	NNP
cord-015021-pol2qm74	8530	22	/	/	SYM
cord-015021-pol2qm74	8530	23	kg	kg	NN
cord-015021-pol2qm74	8530	24	body	body	NN
cord-015021-pol2qm74	8530	25	weight	weight	NN
cord-015021-pol2qm74	8530	26	)	)	-RRB-
cord-015021-pol2qm74	8530	27	results	result	NNS
cord-015021-pol2qm74	8530	28	to	to	TO
cord-015021-pol2qm74	8530	29	be	be	VB
cord-015021-pol2qm74	8530	30	significantly	significantly	RB
cord-015021-pol2qm74	8530	31	effective	effective	JJ
cord-015021-pol2qm74	8530	32	in	in	IN
cord-015021-pol2qm74	8530	33	reducing	reduce	VBG
cord-015021-pol2qm74	8530	34	the	the	DT
cord-015021-pol2qm74	8530	35	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8530	36	-	-	HYPH
cord-015021-pol2qm74	8530	37	induced	induce	VBN
cord-015021-pol2qm74	8530	38	release	release	NN
cord-015021-pol2qm74	8530	39	of	of	IN
cord-015021-pol2qm74	8530	40	serum	serum	NN
cord-015021-pol2qm74	8530	41	TNF	TNF	NNP
cord-015021-pol2qm74	8530	42	.	.	.
cord-015021-pol2qm74	8531	1	The	the	DT
cord-015021-pol2qm74	8531	2	reported	report	VBN
cord-015021-pol2qm74	8531	3	dual	dual	JJ
cord-015021-pol2qm74	8531	4	activity	activity	NN
cord-015021-pol2qm74	8531	5	of	of	IN
cord-015021-pol2qm74	8531	6	ST	ST	NNP
cord-015021-pol2qm74	8531	7	899	899	CD
cord-015021-pol2qm74	8531	8	(	(	-LRB-
cord-015021-pol2qm74	8531	9	i.e.	i.e.	FW
cord-015021-pol2qm74	8531	10	PAF	PAF	NNP
cord-015021-pol2qm74	8531	11	antagonism	antagonism	NN
cord-015021-pol2qm74	8531	12	and	and	CC
cord-015021-pol2qm74	8531	13	decreased	decrease	VBD
cord-015021-pol2qm74	8531	14	circulating	circulate	VBG
cord-015021-pol2qm74	8531	15	TNF	TNF	NNP
cord-015021-pol2qm74	8531	16	levels	level	NNS
cord-015021-pol2qm74	8531	17	)	)	-RRB-
cord-015021-pol2qm74	8531	18	may	may	MD
cord-015021-pol2qm74	8531	19	turn	turn	VB
cord-015021-pol2qm74	8531	20	out	out	RP
cord-015021-pol2qm74	8531	21	to	to	TO
cord-015021-pol2qm74	8531	22	be	be	VB
cord-015021-pol2qm74	8531	23	greatly	greatly	RB
cord-015021-pol2qm74	8531	24	beneficial	beneficial	JJ
cord-015021-pol2qm74	8531	25	,	,	,
cord-015021-pol2qm74	8531	26	in	in	IN
cord-015021-pol2qm74	8531	27	combination	combination	NN
cord-015021-pol2qm74	8531	28	with	with	IN
cord-015021-pol2qm74	8531	29	current	current	JJ
cord-015021-pol2qm74	8531	30	therapies	therapy	NNS
cord-015021-pol2qm74	8531	31	,	,	,
cord-015021-pol2qm74	8531	32	in	in	IN
cord-015021-pol2qm74	8531	33	the	the	DT
cord-015021-pol2qm74	8531	34	treatment	treatment	NN
cord-015021-pol2qm74	8531	35	of	of	IN
cord-015021-pol2qm74	8531	36	diseases	disease	NNS
cord-015021-pol2qm74	8531	37	that	that	WDT
cord-015021-pol2qm74	8531	38	involve	involve	VBP
cord-015021-pol2qm74	8531	39	overproduction	overproduction	NN
cord-015021-pol2qm74	8531	40	of	of	IN
cord-015021-pol2qm74	8531	41	TNF	TNF	NNP
cord-015021-pol2qm74	8531	42	and	and	CC
cord-015021-pol2qm74	8531	43	PAF	PAF	NNP
cord-015021-pol2qm74	8531	44	such	such	JJ
cord-015021-pol2qm74	8531	45	as	as	IN
cord-015021-pol2qm74	8531	46	septic	septic	JJ
cord-015021-pol2qm74	8531	47	shock	shock	NN
cord-015021-pol2qm74	8531	48	.	.	.
cord-015021-pol2qm74	8532	1	Introduction	introduction	NN
cord-015021-pol2qm74	8532	2	:	:	:
cord-015021-pol2qm74	8532	3	Recently	recently	RB
cord-015021-pol2qm74	8532	4	,	,	,
cord-015021-pol2qm74	8532	5	we	-PRON-	PRP
cord-015021-pol2qm74	8532	6	reported	report	VBD
cord-015021-pol2qm74	8532	7	that	that	IN
cord-015021-pol2qm74	8532	8	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	8532	9	whole	whole	JJ
cord-015021-pol2qm74	8532	10	body	body	NN
cord-015021-pol2qm74	8532	11	hyperthermia	hyperthermia	NN
cord-015021-pol2qm74	8532	12	(	(	-LRB-
cord-015021-pol2qm74	8532	13	42.5	42.5	CD
cord-015021-pol2qm74	8532	14	°	°	NN
cord-015021-pol2qm74	8532	15	C	C	NNP
cord-015021-pol2qm74	8532	16	)	)	-RRB-
cord-015021-pol2qm74	8532	17	induces	induce	VBZ
cord-015021-pol2qm74	8532	18	heat	heat	NN
cord-015021-pol2qm74	8532	19	shock	shock	NN
cord-015021-pol2qm74	8532	20	protein	protein	NN
cord-015021-pol2qm74	8532	21	(	(	-LRB-
cord-015021-pol2qm74	8532	22	'	'	``
cord-015021-pol2qm74	8532	23	ASP	ASP	NNP
cord-015021-pol2qm74	8532	24	)	)	-RRB-
cord-015021-pol2qm74	8532	25	72	72	CD
cord-015021-pol2qm74	8532	26	and	and	CC
cord-015021-pol2qm74	8532	27	increases	increase	VBZ
cord-015021-pol2qm74	8532	28	smvival	smvival	NNP
cord-015021-pol2qm74	8532	29	2	2	CD
cord-015021-pol2qm74	8532	30	-	-	SYM
cord-015021-pol2qm74	8532	31	4	4	CD
cord-015021-pol2qm74	8532	32	fold	fold	VBP
cord-015021-pol2qm74	8532	33	in	in	IN
cord-015021-pol2qm74	8532	34	a	a	DT
cord-015021-pol2qm74	8532	35	mouse	mouse	NN
cord-015021-pol2qm74	8532	36	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8532	37	model	model	NN
cord-015021-pol2qm74	8532	38	(	(	-LRB-
cord-015021-pol2qm74	8532	39	Am	am	NN
cord-015021-pol2qm74	8532	40	.	.	.
cord-015021-pol2qm74	8533	1	J.	J.	NNP
cord-015021-pol2qm74	8533	2	Physiol	Physiol	NNP
cord-015021-pol2qm74	8533	3	.	.	.
cord-015021-pol2qm74	8534	1	in	in	IN
cord-015021-pol2qm74	8534	2	press	press	NN
cord-015021-pol2qm74	8534	3	)	)	-RRB-
cord-015021-pol2qm74	8534	4	.	.	.
cord-015021-pol2qm74	8535	1	Other	other	JJ
cord-015021-pol2qm74	8535	2	investigators	investigator	NNS
cord-015021-pol2qm74	8535	3	reported	report	VBD
cord-015021-pol2qm74	8535	4	that	that	IN
cord-015021-pol2qm74	8535	5	prophylactic	prophylactic	JJ
cord-015021-pol2qm74	8535	6	pharmacologic	pharmacologic	JJ
cord-015021-pol2qm74	8535	7	induction	induction	NN
cord-015021-pol2qm74	8535	8	of	of	IN
cord-015021-pol2qm74	8535	9	HSP-72	HSP-72	NNP
cord-015021-pol2qm74	8535	10	by	by	IN
cord-015021-pol2qm74	8535	11	sodium	sodium	NN
cord-015021-pol2qm74	8535	12	arsenite	arsenite	NNP
cord-015021-pol2qm74	8535	13	improves	improve	VBZ
cord-015021-pol2qm74	8535	14	survival	survival	NN
cord-015021-pol2qm74	8535	15	in	in	IN
cord-015021-pol2qm74	8535	16	a	a	DT
cord-015021-pol2qm74	8535	17	rat	rat	NN
cord-015021-pol2qm74	8535	18	sepsis	sepsis	NN
cord-015021-pol2qm74	8535	19	model	model	NN
cord-015021-pol2qm74	8535	20	(	(	-LRB-
cord-015021-pol2qm74	8535	21	abstract	abstract	JJ
cord-015021-pol2qm74	8535	22	A95	A95	NNP
cord-015021-pol2qm74	8535	23	Am	Am	NNP
cord-015021-pol2qm74	8535	24	.	.	.
cord-015021-pol2qm74	8536	1	Rev.	Rev.	NNP
cord-015021-pol2qm74	8536	2	Resp	Resp	NNP
cord-015021-pol2qm74	8536	3	.	.	.
cord-015021-pol2qm74	8537	1	Dis	Dis	NNP
cord-015021-pol2qm74	8537	2	.	.	NNP
cord-015021-pol2qm74	8537	3	Vol	Vol	NNP
cord-015021-pol2qm74	8537	4	.	.	.
cord-015021-pol2qm74	8538	1	147	147	CD
cord-015021-pol2qm74	8538	2	,	,	,
cord-015021-pol2qm74	8538	3	1993	1993	CD
cord-015021-pol2qm74	8538	4	)	)	-RRB-
cord-015021-pol2qm74	8538	5	.	.	.
cord-015021-pol2qm74	8539	1	The	the	DT
cord-015021-pol2qm74	8539	2	effects	effect	NNS
cord-015021-pol2qm74	8539	3	of	of	IN
cord-015021-pol2qm74	8539	4	heat	heat	NN
cord-015021-pol2qm74	8539	5	are	be	VBP
cord-015021-pol2qm74	8539	6	complex	complex	JJ
cord-015021-pol2qm74	8539	7	and	and	CC
cord-015021-pol2qm74	8539	8	in	in	IN
cord-015021-pol2qm74	8539	9	addition	addition	NN
cord-015021-pol2qm74	8539	10	to	to	IN
cord-015021-pol2qm74	8539	11	formation	formation	NN
cord-015021-pol2qm74	8539	12	of	of	IN
cord-015021-pol2qm74	8539	13	liSP-72	liSP-72	NNP
cord-015021-pol2qm74	8539	14	include	include	VB
cord-015021-pol2qm74	8539	15	release	release	NN
cord-015021-pol2qm74	8539	16	of	of	IN
cord-015021-pol2qm74	8539	17	cytokines	cytokine	NNS
cord-015021-pol2qm74	8539	18	,	,	,
cord-015021-pol2qm74	8539	19	changes	change	NNS
cord-015021-pol2qm74	8539	20	in	in	IN
cord-015021-pol2qm74	8539	21	cellular	cellular	JJ
cord-015021-pol2qm74	8539	22	pH	ph	NN
cord-015021-pol2qm74	8539	23	etc	etc	FW
cord-015021-pol2qm74	8539	24	.	.	.
cord-015021-pol2qm74	8540	1	Thus	thus	RB
cord-015021-pol2qm74	8540	2	,	,	,
cord-015021-pol2qm74	8540	3	the	the	DT
cord-015021-pol2qm74	8540	4	protective	protective	JJ
cord-015021-pol2qm74	8540	5	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8540	6	of	of	IN
cord-015021-pol2qm74	8540	7	heat	heat	NN
cord-015021-pol2qm74	8540	8	may	may	MD
cord-015021-pol2qm74	8540	9	differ	differ	VB
cord-015021-pol2qm74	8540	10	from	from	IN
cord-015021-pol2qm74	8540	11	those	those	DT
cord-015021-pol2qm74	8540	12	due	due	JJ
cord-015021-pol2qm74	8540	13	to	to	IN
cord-015021-pol2qm74	8540	14	pharmacologically	pharmacologically	RB
cord-015021-pol2qm74	8540	15	induced	induce	VBN
cord-015021-pol2qm74	8540	16	.	.	.
cord-015021-pol2qm74	8541	1	The	the	DT
cord-015021-pol2qm74	8541	2	purpose	purpose	NN
cord-015021-pol2qm74	8541	3	of	of	IN
cord-015021-pol2qm74	8541	4	this	this	DT
cord-015021-pol2qm74	8541	5	study	study	NN
cord-015021-pol2qm74	8541	6	was	be	VBD
cord-015021-pol2qm74	8541	7	to	to	TO
cord-015021-pol2qm74	8541	8	compare	compare	VB
cord-015021-pol2qm74	8541	9	the	the	DT
cord-015021-pol2qm74	8541	10	protection	protection	NN
cord-015021-pol2qm74	8541	11	of	of	IN
cord-015021-pol2qm74	8541	12	heat	heat	NN
cord-015021-pol2qm74	8541	13	vs	vs	IN
cord-015021-pol2qm74	8541	14	the	the	DT
cord-015021-pol2qm74	8541	15	protection	protection	NN
cord-015021-pol2qm74	8541	16	of	of	IN
cord-015021-pol2qm74	8541	17	pharmacologically	pharmacologically	RB
cord-015021-pol2qm74	8541	18	induced	induce	VBN
cord-015021-pol2qm74	8541	19	HSP-72	HSP-72	NNP
cord-015021-pol2qm74	8541	20	in	in	IN
cord-015021-pol2qm74	8541	21	a	a	DT
cord-015021-pol2qm74	8541	22	mouse	mouse	NN
cord-015021-pol2qm74	8541	23	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8541	24	model	model	NN
cord-015021-pol2qm74	8541	25	to	to	TO
cord-015021-pol2qm74	8541	26	determine	determine	VB
cord-015021-pol2qm74	8541	27	if	if	IN
cord-015021-pol2qm74	8541	28	different	different	JJ
cord-015021-pol2qm74	8541	29	protective	protective	JJ
cord-015021-pol2qm74	8541	30	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8541	31	were	be	VBD
cord-015021-pol2qm74	8541	32	likely	likely	JJ
cord-015021-pol2qm74	8541	33	to	to	TO
cord-015021-pol2qm74	8541	34	be	be	VB
cord-015021-pol2qm74	8541	35	involved	involve	VBN
cord-015021-pol2qm74	8541	36	..	..	.
cord-015021-pol2qm74	8542	1	i%'lethods	i%'lethods	NNP
cord-015021-pol2qm74	8542	2	:	:	:
cord-015021-pol2qm74	8542	3	Both	both	DT
cord-015021-pol2qm74	8542	4	sodium	sodium	NN
cord-015021-pol2qm74	8542	5	arsenite	arsenite	JJ
cord-015021-pol2qm74	8542	6	(	(	-LRB-
cord-015021-pol2qm74	8542	7	10	10	CD
cord-015021-pol2qm74	8542	8	mg	mg	NNP
cord-015021-pol2qm74	8542	9	/	/	SYM
cord-015021-pol2qm74	8542	10	kg	kg	NNP
cord-015021-pol2qm74	8542	11	)	)	-RRB-
cord-015021-pol2qm74	8542	12	and	and	CC
cord-015021-pol2qm74	8542	13	ethanol	ethanol	NN
cord-015021-pol2qm74	8542	14	(	(	-LRB-
cord-015021-pol2qm74	8542	15	400	400	CD
cord-015021-pol2qm74	8542	16	~1	~1	CD
cord-015021-pol2qm74	8542	17	of	of	IN
cord-015021-pol2qm74	8542	18	39	39	CD
cord-015021-pol2qm74	8542	19	%	%	NN
cord-015021-pol2qm74	8542	20	ethanol	ethanol	NN
cord-015021-pol2qm74	8542	21	)	)	-RRB-
cord-015021-pol2qm74	8542	22	caused	cause	VBD
cord-015021-pol2qm74	8542	23	marked	mark	VBN
cord-015021-pol2qm74	8542	24	induction	induction	NN
cord-015021-pol2qm74	8542	25	of	of	IN
cord-015021-pol2qm74	8542	26	HSP-72	HSP-72	NNP
cord-015021-pol2qm74	8542	27	in	in	IN
cord-015021-pol2qm74	8542	28	lung	lung	NN
cord-015021-pol2qm74	8542	29	,	,	,
cord-015021-pol2qm74	8542	30	gut	gut	NN
cord-015021-pol2qm74	8542	31	,	,	,
cord-015021-pol2qm74	8542	32	kidney	kidney	NN
cord-015021-pol2qm74	8542	33	,	,	,
cord-015021-pol2qm74	8542	34	and	and	CC
cord-015021-pol2qm74	8542	35	liver	liver	NN
cord-015021-pol2qm74	8542	36	,	,	,
cord-015021-pol2qm74	8542	37	which	which	WDT
cord-015021-pol2qm74	8542	38	was	be	VBD
cord-015021-pol2qm74	8542	39	comparable	comparable	JJ
cord-015021-pol2qm74	8542	40	to	to	IN
cord-015021-pol2qm74	8542	41	heat	heat	NN
cord-015021-pol2qm74	8542	42	-	-	HYPH
cord-015021-pol2qm74	8542	43	induced	induce	VBN
cord-015021-pol2qm74	8542	44	HSP-72	HSP-72	NNP
cord-015021-pol2qm74	8542	45	.	.	.
cord-015021-pol2qm74	8543	1	Female	female	JJ
cord-015021-pol2qm74	8543	2	ND4	ND4	NNP
cord-015021-pol2qm74	8543	3	mice	mouse	NNS
cord-015021-pol2qm74	8543	4	weighing	weigh	VBG
cord-015021-pol2qm74	8543	5	22	22	CD
cord-015021-pol2qm74	8543	6	-	-	SYM
cord-015021-pol2qm74	8543	7	25	25	CD
cord-015021-pol2qm74	8543	8	gms	gm	NNS
cord-015021-pol2qm74	8543	9	were	be	VBD
cord-015021-pol2qm74	8543	10	pretreated	pretreate	VBN
cord-015021-pol2qm74	8543	11	with	with	IN
cord-015021-pol2qm74	8543	12	arsenite	arsenite	JJ
cord-015021-pol2qm74	8543	13	or	or	CC
cord-015021-pol2qm74	8543	14	alcohol	alcohol	NN
cord-015021-pol2qm74	8543	15	8	8	CD
cord-015021-pol2qm74	8543	16	hours	hour	NNS
cord-015021-pol2qm74	8543	17	prior	prior	RB
cord-015021-pol2qm74	8543	18	to	to	TO
cord-015021-pol2qm74	8543	19	challenge	challenge	NN
cord-015021-pol2qm74	8543	20	with	with	IN
cord-015021-pol2qm74	8543	21	Escherichia	Escherichia	NNP
cord-015021-pol2qm74	8543	22	coli	coli	NNS
cord-015021-pol2qm74	8543	23	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8543	24	(	(	-LRB-
cord-015021-pol2qm74	8543	25	-LD	-LD	NNS
cord-015021-pol2qm74	8543	26	80	80	CD
cord-015021-pol2qm74	8543	27	)	)	-RRB-
cord-015021-pol2qm74	8543	28	and	and	CC
cord-015021-pol2qm74	8543	29	survival	survival	NN
cord-015021-pol2qm74	8543	30	was	be	VBD
cord-015021-pol2qm74	8543	31	compared	compare	VBN
cord-015021-pol2qm74	8543	32	to	to	TO
cord-015021-pol2qm74	8543	33	control	control	VB
cord-015021-pol2qm74	8543	34	mice	mouse	NNS
cord-015021-pol2qm74	8543	35	.	.	.
cord-015021-pol2qm74	8544	1	Results	result	NNS
cord-015021-pol2qm74	8544	2	:	:	:
cord-015021-pol2qm74	8544	3	Survival	survival	NN
cord-015021-pol2qm74	8544	4	at	at	IN
cord-015021-pol2qm74	8544	5	24	24	CD
cord-015021-pol2qm74	8544	6	hrs	hrs	NN
cord-015021-pol2qm74	8544	7	.	.	.
cord-015021-pol2qm74	8545	1	for	for	IN
cord-015021-pol2qm74	8545	2	arsenite	arsenite	NNP
cord-015021-pol2qm74	8545	3	treated	treat	VBN
cord-015021-pol2qm74	8545	4	and	and	CC
cord-015021-pol2qm74	8545	5	alcohol	alcohol	NN
cord-015021-pol2qm74	8545	6	treated	treat	VBN
cord-015021-pol2qm74	8546	1	mice	mouse	NNS
cord-015021-pol2qm74	8546	2	was	be	VBD
cord-015021-pol2qm74	8546	3	96	96	CD
cord-015021-pol2qm74	8546	4	%	%	NN
cord-015021-pol2qm74	8546	5	and	and	CC
cord-015021-pol2qm74	8546	6	88	88	CD
cord-015021-pol2qm74	8546	7	%	%	NN
cord-015021-pol2qm74	8546	8	respectively	respectively	RB
cord-015021-pol2qm74	8546	9	and	and	CC
cord-015021-pol2qm74	8546	10	was	be	VBD
cord-015021-pol2qm74	8546	11	statistically	statistically	RB
cord-015021-pol2qm74	8546	12	different	different	JJ
cord-015021-pol2qm74	8546	13	from	from	IN
cord-015021-pol2qm74	8546	14	the	the	DT
cord-015021-pol2qm74	8546	15	40	40	CD
cord-015021-pol2qm74	8546	16	%	%	NN
cord-015021-pol2qm74	8546	17	survival	survival	NN
cord-015021-pol2qm74	8546	18	for	for	IN
cord-015021-pol2qm74	8546	19	control	control	NN
cord-015021-pol2qm74	8546	20	mice	mouse	NNS
cord-015021-pol2qm74	8546	21	.	.	.
cord-015021-pol2qm74	8547	1	(	(	-LRB-
cord-015021-pol2qm74	8547	2	p<0.01	p<0.01	NN
cord-015021-pol2qm74	8547	3	)	)	-RRB-
cord-015021-pol2qm74	8548	1	(	(	-LRB-
cord-015021-pol2qm74	8548	2	n=25	n=25	JJ
cord-015021-pol2qm74	8548	3	mice	mouse	NNS
cord-015021-pol2qm74	8548	4	per	per	IN
cord-015021-pol2qm74	8548	5	group	group	NN
cord-015021-pol2qm74	8548	6	)	)	-RRB-
cord-015021-pol2qm74	8548	7	.	.	.
cord-015021-pol2qm74	8549	1	However	however	RB
cord-015021-pol2qm74	8549	2	,	,	,
cord-015021-pol2qm74	8549	3	at	at	IN
cord-015021-pol2qm74	8549	4	7	7	CD
cord-015021-pol2qm74	8549	5	days	day	NNS
cord-015021-pol2qm74	8549	6	post	post	NN
cord-015021-pol2qm74	8549	7	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8549	8	,	,	,
cord-015021-pol2qm74	8549	9	there	there	EX
cord-015021-pol2qm74	8549	10	were	be	VBD
cord-015021-pol2qm74	8549	11	no	no	DT
cord-015021-pol2qm74	8549	12	differences	difference	NNS
cord-015021-pol2qm74	8549	13	in	in	IN
cord-015021-pol2qm74	8549	14	survival	survival	NN
cord-015021-pol2qm74	8549	15	in	in	IN
cord-015021-pol2qm74	8549	16	the	the	DT
cord-015021-pol2qm74	8549	17	3	3	CD
cord-015021-pol2qm74	8549	18	groups	group	NNS
cord-015021-pol2qm74	8549	19	,	,	,
cord-015021-pol2qm74	8549	20	i.e.	i.e.	FW
cord-015021-pol2qm74	8549	21	,	,	,
cord-015021-pol2qm74	8549	22	~	~	CD
cord-015021-pol2qm74	8549	23	4	4	CD
cord-015021-pol2qm74	8549	24	%	%	NN
cord-015021-pol2qm74	8549	25	survival	survival	NN
cord-015021-pol2qm74	8549	26	for	for	IN
cord-015021-pol2qm74	8549	27	all	all	DT
cord-015021-pol2qm74	8549	28	3	3	CD
cord-015021-pol2qm74	8549	29	groups	group	NNS
cord-015021-pol2qm74	8549	30	.	.	.
cord-015021-pol2qm74	8550	1	In	in	IN
cord-015021-pol2qm74	8550	2	contrast	contrast	NN
cord-015021-pol2qm74	8550	3	,	,	,
cord-015021-pol2qm74	8550	4	the	the	DT
cord-015021-pol2qm74	8550	5	protective	protective	JJ
cord-015021-pol2qm74	8550	6	effect	effect	NN
cord-015021-pol2qm74	8550	7	of	of	IN
cord-015021-pol2qm74	8550	8	hyperthermia	hyperthermia	NN
cord-015021-pol2qm74	8550	9	remains	remain	VBZ
cord-015021-pol2qm74	8550	10	present	present	JJ
cord-015021-pol2qm74	8550	11	at	at	IN
cord-015021-pol2qm74	8550	12	7	7	CD
cord-015021-pol2qm74	8550	13	days	day	NNS
cord-015021-pol2qm74	8550	14	,	,	,
cord-015021-pol2qm74	8550	15	i.e.	i.e.	FW
cord-015021-pol2qm74	8550	16	,	,	,
cord-015021-pol2qm74	8550	17	~	~	NFP
cord-015021-pol2qm74	8550	18	70	70	CD
cord-015021-pol2qm74	8550	19	%	%	NN
cord-015021-pol2qm74	8550	20	survival	survival	NN
cord-015021-pol2qm74	8550	21	vs	vs	IN
cord-015021-pol2qm74	8550	22	20	20	CD
cord-015021-pol2qm74	8550	23	%	%	NN
cord-015021-pol2qm74	8550	24	survival	survival	NN
cord-015021-pol2qm74	8550	25	control	control	NN
cord-015021-pol2qm74	8550	26	.	.	.
cord-015021-pol2qm74	8551	1	Conclusion	conclusion	NN
cord-015021-pol2qm74	8551	2	:	:	:
cord-015021-pol2qm74	8552	1	The	the	DT
cord-015021-pol2qm74	8552	2	protective	protective	JJ
cord-015021-pol2qm74	8552	3	effect	effect	NN
cord-015021-pol2qm74	8552	4	of	of	IN
cord-015021-pol2qm74	8552	5	heat	heat	NN
cord-015021-pol2qm74	8552	6	is	be	VBZ
cord-015021-pol2qm74	8552	7	probably	probably	RB
cord-015021-pol2qm74	8552	8	due	due	JJ
cord-015021-pol2qm74	8552	9	to	to	IN
cord-015021-pol2qm74	8552	10	other	other	JJ
cord-015021-pol2qm74	8552	11	factors	factor	NNS
cord-015021-pol2qm74	8552	12	such	such	JJ
cord-015021-pol2qm74	8552	13	as	as	IN
cord-015021-pol2qm74	8552	14	the	the	DT
cord-015021-pol2qm74	8552	15	effect	effect	NN
cord-015021-pol2qm74	8552	16	of	of	IN
cord-015021-pol2qm74	8552	17	hyperthermia	hyperthermia	NN
cord-015021-pol2qm74	8552	18	to	to	TO
cord-015021-pol2qm74	8552	19	release	release	VB
cord-015021-pol2qm74	8552	20	IL	IL	NNP
cord-015021-pol2qm74	8552	21	-	-	HYPH
cord-015021-pol2qm74	8552	22	lc~	lc~	NN
cord-015021-pol2qm74	8552	23	and	and	CC
cord-015021-pol2qm74	8552	24	is	be	VBZ
cord-015021-pol2qm74	8552	25	not	not	RB
cord-015021-pol2qm74	8552	26	due	due	JJ
cord-015021-pol2qm74	8552	27	solely	solely	RB
cord-015021-pol2qm74	8552	28	to	to	IN
cord-015021-pol2qm74	8552	29	HSP-72	HSP-72	NNP
cord-015021-pol2qm74	8552	30	formation	formation	NN
cord-015021-pol2qm74	8552	31	.	.	.
cord-015021-pol2qm74	8553	1	It	-PRON-	PRP
cord-015021-pol2qm74	8553	2	was	be	VBD
cord-015021-pol2qm74	8553	3	the	the	DT
cord-015021-pol2qm74	8553	4	aim	aim	NN
cord-015021-pol2qm74	8553	5	of	of	IN
cord-015021-pol2qm74	8553	6	the	the	DT
cord-015021-pol2qm74	8553	7	study	study	NN
cord-015021-pol2qm74	8553	8	to	to	TO
cord-015021-pol2qm74	8553	9	examine	examine	VB
cord-015021-pol2qm74	8553	10	whether	whether	IN
cord-015021-pol2qm74	8553	11	bacteria	bacteria	NNS
cord-015021-pol2qm74	8553	12	play	play	VBP
cord-015021-pol2qm74	8553	13	a	a	DT
cord-015021-pol2qm74	8553	14	causative	causative	JJ
cord-015021-pol2qm74	8553	15	role	role	NN
cord-015021-pol2qm74	8553	16	in	in	IN
cord-015021-pol2qm74	8553	17	the	the	DT
cord-015021-pol2qm74	8553	18	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8553	19	of	of	IN
cord-015021-pol2qm74	8553	20	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	8553	21	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8553	22	following	follow	VBG
cord-015021-pol2qm74	8553	23	gastrectomy	gastrectomy	NN
cord-015021-pol2qm74	8553	24	in	in	IN
cord-015021-pol2qm74	8553	25	man	man	NN
cord-015021-pol2qm74	8553	26	.	.	.
cord-015021-pol2qm74	8554	1	The	the	DT
cord-015021-pol2qm74	8554	2	study	study	NN
cord-015021-pol2qm74	8554	3	was	be	VBD
cord-015021-pol2qm74	8554	4	carried	carry	VBN
cord-015021-pol2qm74	8554	5	out	out	RP
cord-015021-pol2qm74	8554	6	in	in	IN
cord-015021-pol2qm74	8554	7	form	form	NN
cord-015021-pol2qm74	8554	8	of	of	IN
cord-015021-pol2qm74	8554	9	a	a	DT
cord-015021-pol2qm74	8554	10	prospective	prospective	NN
cord-015021-pol2qm74	8554	11	,	,	,
cord-015021-pol2qm74	8554	12	randemised	randemised	JJ
cord-015021-pol2qm74	8554	13	,	,	,
cord-015021-pol2qm74	8554	14	double	double	JJ
cord-015021-pol2qm74	8554	15	-	-	HYPH
cord-015021-pol2qm74	8554	16	blind	blind	JJ
cord-015021-pol2qm74	8554	17	,	,	,
cord-015021-pol2qm74	8554	18	multicenter	multicenter	JJ
cord-015021-pol2qm74	8554	19	trial	trial	NN
cord-015021-pol2qm74	8554	20	.	.	.
cord-015021-pol2qm74	8555	1	Primary	primary	JJ
cord-015021-pol2qm74	8555	2	endpoints	endpoint	NNS
cord-015021-pol2qm74	8555	3	were	be	VBD
cord-015021-pol2qm74	8555	4	the	the	DT
cord-015021-pol2qm74	8555	5	rate	rate	NN
cord-015021-pol2qm74	8555	6	of	of	IN
cord-015021-pol2qm74	8555	7	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	8555	8	insufficiencies	insufficiency	NNS
cord-015021-pol2qm74	8555	9	,	,	,
cord-015021-pol2qm74	8555	10	infectious	infectious	JJ
cord-015021-pol2qm74	8555	11	-	-	HYPH
cord-015021-pol2qm74	8555	12	and	and	CC
cord-015021-pol2qm74	8555	13	uncomplicated	uncomplicated	JJ
cord-015021-pol2qm74	8555	14	postoperative	postoperative	JJ
cord-015021-pol2qm74	8555	15	courses	course	NNS
cord-015021-pol2qm74	8555	16	.	.	.
cord-015021-pol2qm74	8556	1	All	all	DT
cord-015021-pol2qm74	8556	2	pat	pat	VBP
cord-015021-pol2qm74	8556	3	.	.	NNP
cord-015021-pol2qm74	8556	4	received	receive	VBD
cord-015021-pol2qm74	8556	5	a	a	DT
cord-015021-pol2qm74	8556	6	periop	periop	NNS
cord-015021-pol2qm74	8556	7	,	,	,
cord-015021-pol2qm74	8556	8	i.v	i.v	NNP
cord-015021-pol2qm74	8556	9	.	.	NNP
cord-015021-pol2qm74	8556	10	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	8556	11	with	with	IN
cord-015021-pol2qm74	8556	12	Cefotaxim	Cefotaxim	NNP
cord-015021-pol2qm74	8556	13	.	.	.
cord-015021-pol2qm74	8557	1	Identical	identical	JJ
cord-015021-pol2qm74	8557	2	numbered	number	VBN
cord-015021-pol2qm74	8557	3	vial	vial	NN
cord-015021-pol2qm74	8557	4	either	either	CC
cord-015021-pol2qm74	8557	5	contained	contain	VBD
cord-015021-pol2qm74	8557	6	Placebo	Placebo	NNP
cord-015021-pol2qm74	8557	7	or	or	CC
cord-015021-pol2qm74	8557	8	Polymyxin	Polymyxin	NNP
cord-015021-pol2qm74	8557	9	B	B	NNP
cord-015021-pol2qm74	8557	10	,	,	,
cord-015021-pol2qm74	8557	11	Tobramycin	Tobramycin	NNPS
cord-015021-pol2qm74	8557	12	,	,	,
cord-015021-pol2qm74	8557	13	Vancomycin	Vancomycin	NNP
cord-015021-pol2qm74	8557	14	and	and	CC
cord-015021-pol2qm74	8557	15	Amphotericin	Amphotericin	NNP
cord-015021-pol2qm74	8557	16	B	B	NNP
cord-015021-pol2qm74	8557	17	.	.	.
cord-015021-pol2qm74	8558	1	The	the	DT
cord-015021-pol2qm74	8558	2	vials	vial	NNS
cord-015021-pol2qm74	8558	3	were	be	VBD
cord-015021-pol2qm74	8558	4	administered	administer	VBN
cord-015021-pol2qm74	8558	5	4X	4x	CD
cord-015021-pol2qm74	8558	6	per	per	IN
cord-015021-pol2qm74	8558	7	day	day	NN
cord-015021-pol2qm74	8558	8	from	from	IN
cord-015021-pol2qm74	8558	9	the	the	DT
cord-015021-pol2qm74	8558	10	day	day	NN
cord-015021-pol2qm74	8558	11	be	be	VB
cord-015021-pol2qm74	8558	12	~	~	NFP
cord-015021-pol2qm74	8558	13	fore	fore	IN
cord-015021-pol2qm74	8558	14	the	the	DT
cord-015021-pol2qm74	8558	15	operation	operation	NN
cord-015021-pol2qm74	8558	16	until	until	IN
cord-015021-pol2qm74	8558	17	the	the	DT
cord-015021-pol2qm74	8558	18	7th	7th	JJ
cord-015021-pol2qm74	8558	19	postop	postop	NN
cord-015021-pol2qm74	8558	20	,	,	,
cord-015021-pol2qm74	8558	21	day	day	NN
cord-015021-pol2qm74	8558	22	.	.	.
cord-015021-pol2qm74	8559	1	Insufficiencies	insufficiency	NNS
cord-015021-pol2qm74	8559	2	were	be	VBD
cord-015021-pol2qm74	8559	3	detected	detect	VBN
cord-015021-pol2qm74	8559	4	by	by	IN
cord-015021-pol2qm74	8559	5	gastrographin	gastrographin	NNP
cord-015021-pol2qm74	8559	6	swallow	swallow	NNP
cord-015021-pol2qm74	8559	7	and	and	CC
cord-015021-pol2qm74	8559	8	recorded	record	VBN
cord-015021-pol2qm74	8559	9	by	by	IN
cord-015021-pol2qm74	8559	10	X	x	NN
cord-015021-pol2qm74	8559	11	-	-	NN
cord-015021-pol2qm74	8559	12	ray	ray	NN
cord-015021-pol2qm74	8559	13	on	on	IN
cord-015021-pol2qm74	8559	14	day	day	NN
cord-015021-pol2qm74	8559	15	7	7	CD
cord-015021-pol2qm74	8559	16	postop	postop	NN
cord-015021-pol2qm74	8559	17	..	..	.
cord-015021-pol2qm74	8560	1	Evaluation	evaluation	NN
cord-015021-pol2qm74	8560	2	was	be	VBD
cord-015021-pol2qm74	8560	3	carried	carry	VBN
cord-015021-pol2qm74	8560	4	out	out	RP
cord-015021-pol2qm74	8560	5	on	on	IN
cord-015021-pol2qm74	8560	6	an	an	DT
cord-015021-pol2qm74	8560	7	"	"	``
cord-015021-pol2qm74	8560	8	intention	intention	NN
cord-015021-pol2qm74	8560	9	to	to	IN
cord-015021-pol2qm74	8560	10	treat'basis	treat'basis	ADD
cord-015021-pol2qm74	8560	11	.	.	.
cord-015021-pol2qm74	8561	1	Statistical	statistical	JJ
cord-015021-pol2qm74	8561	2	analysis	analysis	NN
cord-015021-pol2qm74	8561	3	was	be	VBD
cord-015021-pol2qm74	8561	4	done	do	VBN
cord-015021-pol2qm74	8561	5	with	with	IN
cord-015021-pol2qm74	8561	6	the	the	DT
cord-015021-pol2qm74	8561	7	Pearson	Pearson	NNP
cord-015021-pol2qm74	8561	8	's	's	POS
cord-015021-pol2qm74	8561	9	Chi	Chi	NNP
cord-015021-pol2qm74	8561	10	Square	Square	NNP
cord-015021-pol2qm74	8561	11	and	and	CC
cord-015021-pol2qm74	8561	12	Fisher	Fisher	NNP
cord-015021-pol2qm74	8561	13	's	's	POS
cord-015021-pol2qm74	8561	14	Exact	exact	JJ
cord-015021-pol2qm74	8561	15	Tests~	Tests~	.
cord-015021-pol2qm74	8561	16	Results	result	NNS
cord-015021-pol2qm74	8561	17	:	:	:
cord-015021-pol2qm74	8561	18	Interim	interim	JJ
cord-015021-pol2qm74	8561	19	analysis	analysis	NN
cord-015021-pol2qm74	8561	20	was	be	VBD
cord-015021-pol2qm74	8561	21	carried	carry	VBN
cord-015021-pol2qm74	8561	22	out	out	RP
cord-015021-pol2qm74	8561	23	in	in	IN
cord-015021-pol2qm74	8561	24	3/93	3/93	CD
cord-015021-pol2qm74	8561	25	after	after	IN
cord-015021-pol2qm74	8561	26	137	137	CD
cord-015021-pol2qm74	8561	27	pat	pat	NNS
cord-015021-pol2qm74	8561	28	.	.	NNP
cord-015021-pol2qm74	8561	29	had	have	VBD
cord-015021-pol2qm74	8561	30	been	be	VBN
cord-015021-pol2qm74	8561	31	recruited	recruit	VBN
cord-015021-pol2qm74	8561	32	.	.	.
cord-015021-pol2qm74	8562	1	Along	along	IN
cord-015021-pol2qm74	8562	2	with	with	IN
cord-015021-pol2qm74	8562	3	a	a	DT
cord-015021-pol2qm74	8562	4	significant	significant	JJ
cord-015021-pol2qm74	8562	5	reduction	reduction	NN
cord-015021-pol2qm74	8562	6	of	of	IN
cord-015021-pol2qm74	8562	7	S.aureus	s.aureu	NNS
cord-015021-pol2qm74	8562	8	and	and	CC
cord-015021-pol2qm74	8562	9	enterobacteria	enterobacteria	NN
cord-015021-pol2qm74	8562	10	there	there	EX
cord-015021-pol2qm74	8562	11	was	be	VBD
cord-015021-pol2qm74	8562	12	a	a	DT
cord-015021-pol2qm74	8562	13	reduction	reduction	NN
cord-015021-pol2qm74	8562	14	in	in	IN
cord-015021-pol2qm74	8562	15	the	the	DT
cord-015021-pol2qm74	8562	16	rate	rate	NN
cord-015021-pol2qm74	8562	17	of	of	IN
cord-015021-pol2qm74	8562	18	anastomotic	anastomotic	JJ
cord-015021-pol2qm74	8562	19	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8562	20	of	of	IN
cord-015021-pol2qm74	8562	21	the	the	DT
cord-015021-pol2qm74	8562	22	esophago	esophago	JJ
cord-015021-pol2qm74	8562	23	-	-	HYPH
cord-015021-pol2qm74	8562	24	jejunostomy	jejunostomy	NN
cord-015021-pol2qm74	8562	25	from	from	IN
cord-015021-pol2qm74	8562	26	10.6	10.6	CD
cord-015021-pol2qm74	8562	27	%	%	NN
cord-015021-pol2qm74	8562	28	in	in	IN
cord-015021-pol2qm74	8562	29	the	the	DT
cord-015021-pol2qm74	8562	30	Placebo	Placebo	NNP
cord-015021-pol2qm74	8562	31	-	-	HYPH
cord-015021-pol2qm74	8562	32	group	group	NN
cord-015021-pol2qm74	8562	33	to	to	IN
cord-015021-pol2qm74	8562	34	3.5	3.5	CD
cord-015021-pol2qm74	8562	35	%	%	NN
cord-015021-pol2qm74	8562	36	in	in	IN
cord-015021-pol2qm74	8562	37	the	the	DT
cord-015021-pol2qm74	8562	38	treatment	treatment	NN
cord-015021-pol2qm74	8562	39	group	group	NN
cord-015021-pol2qm74	8562	40	.	.	.
cord-015021-pol2qm74	8563	1	The	the	DT
cord-015021-pol2qm74	8563	2	difference	difference	NN
cord-015021-pol2qm74	8563	3	was	be	VBD
cord-015021-pol2qm74	8563	4	not	not	RB
cord-015021-pol2qm74	8563	5	yet	yet	RB
cord-015021-pol2qm74	8563	6	significant	significant	JJ
cord-015021-pol2qm74	8563	7	.	.	.
cord-015021-pol2qm74	8564	1	The	the	DT
cord-015021-pol2qm74	8564	2	rate	rate	NN
cord-015021-pol2qm74	8564	3	of	of	IN
cord-015021-pol2qm74	8564	4	nosocomial	nosocomial	JJ
cord-015021-pol2qm74	8564	5	infections	infection	NNS
cord-015021-pol2qm74	8564	6	(	(	-LRB-
cord-015021-pol2qm74	8564	7	e.g.	e.g.	RB
cord-015021-pol2qm74	8564	8	respiratory	respiratory	JJ
cord-015021-pol2qm74	8564	9	tract	tract	NN
cord-015021-pol2qm74	8564	10	infection	infection	NN
cord-015021-pol2qm74	8564	11	and	and	CC
cord-015021-pol2qm74	8564	12	UTI	UTI	NNP
cord-015021-pol2qm74	8564	13	)	)	-RRB-
cord-015021-pol2qm74	8564	14	were	be	VBD
cord-015021-pol2qm74	8564	15	significantly	significantly	RB
cord-015021-pol2qm74	8564	16	reduced	reduce	VBN
cord-015021-pol2qm74	8564	17	from	from	IN
cord-015021-pol2qm74	8564	18	33.3	33.3	CD
cord-015021-pol2qm74	8564	19	%	%	NN
cord-015021-pol2qm74	8564	20	in	in	IN
cord-015021-pol2qm74	8564	21	the	the	DT
cord-015021-pol2qm74	8564	22	Placebo	Placebo	NNP
cord-015021-pol2qm74	8564	23	-	-	HYPH
cord-015021-pol2qm74	8564	24	group	group	NN
cord-015021-pol2qm74	8564	25	to	to	IN
cord-015021-pol2qm74	8564	26	16.4	16.4	CD
cord-015021-pol2qm74	8564	27	%	%	NN
cord-015021-pol2qm74	8564	28	in	in	IN
cord-015021-pol2qm74	8564	29	the	the	DT
cord-015021-pol2qm74	8564	30	Treatment	treatment	NN
cord-015021-pol2qm74	8564	31	-	-	HYPH
cord-015021-pol2qm74	8564	32	group	group	NN
cord-015021-pol2qm74	8564	33	(	(	-LRB-
cord-015021-pol2qm74	8564	34	p	p	NN
cord-015021-pol2qm74	8564	35	~	~	NFP
cord-015021-pol2qm74	8564	36	0.0281;Fisher	0.0281;fisher	CD
cord-015021-pol2qm74	8564	37	's	's	POS
cord-015021-pol2qm74	8564	38	Exact	Exact	NNP
cord-015021-pol2qm74	8564	39	Test	Test	NNP
cord-015021-pol2qm74	8564	40	)	)	-RRB-
cord-015021-pol2qm74	8564	41	.	.	.
cord-015021-pol2qm74	8565	1	In	in	IN
cord-015021-pol2qm74	8565	2	march	march	NNP
cord-015021-pol2qm74	8565	3	1994	1994	CD
cord-015021-pol2qm74	8565	4	final	final	JJ
cord-015021-pol2qm74	8565	5	results	result	NNS
cord-015021-pol2qm74	8565	6	with	with	IN
cord-015021-pol2qm74	8565	7	more	more	JJR
cord-015021-pol2qm74	8565	8	than	than	IN
cord-015021-pol2qm74	8565	9	200	200	CD
cord-015021-pol2qm74	8565	10	patients	patient	NNS
cord-015021-pol2qm74	8565	11	will	will	MD
cord-015021-pol2qm74	8565	12	be	be	VB
cord-015021-pol2qm74	8565	13	presented	present	VBN
cord-015021-pol2qm74	8565	14	for	for	IN
cord-015021-pol2qm74	8565	15	the	the	DT
cord-015021-pol2qm74	8565	16	first	first	JJ
cord-015021-pol2qm74	8565	17	time	time	NN
cord-015021-pol2qm74	8565	18	.	.	.
cord-015021-pol2qm74	8566	1	(=	(=	NNP
cord-015021-pol2qm74	8566	2	pO2	pO2	NNP
cord-015021-pol2qm74	8566	3	<	<	XX
cord-015021-pol2qm74	8567	1	80	80	CD
cord-015021-pol2qm74	8567	2	mm	mm	NN
cord-015021-pol2qm74	8568	1	Hg	Hg	NNP
cord-015021-pol2qm74	8568	2	,	,	,
cord-015021-pol2qm74	8568	3	b	b	NNP
cord-015021-pol2qm74	8568	4	s	s	POS
cord-015021-pol2qm74	8568	5	-	-	HYPH
cord-015021-pol2qm74	8568	6	creatinin	creatinin	NNP
cord-015021-pol2qm74	8568	7	>	>	XX
cord-015021-pol2qm74	8568	8	2	2	CD
cord-015021-pol2qm74	8568	9	mg%	mg%	CD
cord-015021-pol2qm74	8568	10	)	)	-RRB-
cord-015021-pol2qm74	8568	11	.	.	.
cord-015021-pol2qm74	8569	1	Respiratory	respiratory	JJ
cord-015021-pol2qm74	8569	2	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8569	3	was	be	VBD
cord-015021-pol2qm74	8569	4	the	the	DT
cord-015021-pol2qm74	8569	5	most	most	RBS
cord-015021-pol2qm74	8569	6	frequent	frequent	JJ
cord-015021-pol2qm74	8569	7	systemic	systemic	JJ
cord-015021-pol2qm74	8569	8	complication	complication	NN
cord-015021-pol2qm74	8569	9	followed	follow	VBN
cord-015021-pol2qm74	8569	10	by	by	IN
cord-015021-pol2qm74	8569	11	sepsis	sepsis	NN
cord-015021-pol2qm74	8569	12	and	and	CC
cord-015021-pol2qm74	8569	13	respiratory	respiratory	JJ
cord-015021-pol2qm74	8569	14	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8569	15	.	.	.
cord-015021-pol2qm74	8570	1	Etiology	etiology	NN
cord-015021-pol2qm74	8570	2	of	of	IN
cord-015021-pol2qm74	8570	3	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8570	4	and	and	CC
cord-015021-pol2qm74	8570	5	initial	initial	JJ
cord-015021-pol2qm74	8570	6	serum	serum	NN
cord-015021-pol2qm74	8570	7	increase	increase	NN
cord-015021-pol2qm74	8570	8	of	of	IN
cord-015021-pol2qm74	8570	9	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8570	10	enzymes	enzyme	NNS
cord-015021-pol2qm74	8570	11	predicted	predict	VBD
cord-015021-pol2qm74	8570	12	neither	neither	CC
cord-015021-pol2qm74	8570	13	complications	complication	NNS
cord-015021-pol2qm74	8570	14	nor	nor	CC
cord-015021-pol2qm74	8570	15	outcome	outcome	NN
cord-015021-pol2qm74	8570	16	.	.	.
cord-015021-pol2qm74	8571	1	Only	only	RB
cord-015021-pol2qm74	8571	2	2	2	CD
cord-015021-pol2qm74	8571	3	of	of	IN
cord-015021-pol2qm74	8571	4	14	14	CD
cord-015021-pol2qm74	8571	5	deaths	death	NNS
cord-015021-pol2qm74	8571	6	occurred	occur	VBD
cord-015021-pol2qm74	8571	7	during	during	IN
cord-015021-pol2qm74	8571	8	the	the	DT
cord-015021-pol2qm74	8571	9	1st	1st	JJ
cord-015021-pol2qm74	8571	10	week	week	NN
cord-015021-pol2qm74	8571	11	,	,	,
cord-015021-pol2qm74	8571	12	all	all	DT
cord-015021-pol2qm74	8571	13	other	other	JJ
cord-015021-pol2qm74	8571	14	deaths	death	NNS
cord-015021-pol2qm74	8571	15	occurred	occur	VBD
cord-015021-pol2qm74	8571	16	late	late	RB
cord-015021-pol2qm74	8571	17	(	(	-LRB-
cord-015021-pol2qm74	8571	18	after	after	IN
cord-015021-pol2qm74	8571	19	4	4	CD
cord-015021-pol2qm74	8571	20	-	-	SYM
cord-015021-pol2qm74	8571	21	12	12	CD
cord-015021-pol2qm74	8571	22	weeks	week	NNS
cord-015021-pol2qm74	8571	23	)	)	-RRB-
cord-015021-pol2qm74	8571	24	,	,	,
cord-015021-pol2qm74	8571	25	generally	generally	RB
cord-015021-pol2qm74	8571	26	as	as	IN
cord-015021-pol2qm74	8571	27	the	the	DT
cord-015021-pol2qm74	8571	28	consequence	consequence	NN
cord-015021-pol2qm74	8571	29	of	of	IN
cord-015021-pol2qm74	8571	30	septic	septic	JJ
cord-015021-pol2qm74	8571	31	complications	complication	NNS
cord-015021-pol2qm74	8571	32	and	and	CC
cord-015021-pol2qm74	8571	33	multi	multi	JJ
cord-015021-pol2qm74	8571	34	-	-	JJ
cord-015021-pol2qm74	8571	35	organ	organ	JJ
cord-015021-pol2qm74	8571	36	failure	failure	NN
cord-015021-pol2qm74	8571	37	.	.	.
cord-015021-pol2qm74	8572	1	High	high	JJ
cord-015021-pol2qm74	8572	2	levels	level	NNS
cord-015021-pol2qm74	8572	3	of	of	IN
cord-015021-pol2qm74	8572	4	CRP	CRP	NNP
cord-015021-pol2qm74	8572	5	were	be	VBD
cord-015021-pol2qm74	8572	6	correlated	correlate	VBN
cord-015021-pol2qm74	8572	7	with	with	IN
cord-015021-pol2qm74	8572	8	a	a	DT
cord-015021-pol2qm74	8572	9	compliacted	compliacted	JJ
cord-015021-pol2qm74	8572	10	course	course	NN
cord-015021-pol2qm74	8572	11	and	and	CC
cord-015021-pol2qm74	8572	12	a	a	DT
cord-015021-pol2qm74	8572	13	fatal	fatal	JJ
cord-015021-pol2qm74	8572	14	outcome	outcome	NN
cord-015021-pol2qm74	8572	15	.	.	.
cord-015021-pol2qm74	8573	1	Although	although	IN
cord-015021-pol2qm74	8573	2	same	same	JJ
cord-015021-pol2qm74	8573	3	cytokines	cytokine	NNS
cord-015021-pol2qm74	8573	4	(	(	-LRB-
cord-015021-pol2qm74	8573	5	e.g.	e.g.	RB
cord-015021-pol2qm74	8573	6	11	11	CD
cord-015021-pol2qm74	8573	7	-	-	HYPH
cord-015021-pol2qm74	8573	8	-6	-6	NN
cord-015021-pol2qm74	8573	9	)	)	-RRB-
cord-015021-pol2qm74	8573	10	were	be	VBD
cord-015021-pol2qm74	8573	11	found	find	VBN
cord-015021-pol2qm74	8573	12	increased	increase	VBN
cord-015021-pol2qm74	8573	13	in	in	IN
cord-015021-pol2qm74	8573	14	severe	severe	JJ
cord-015021-pol2qm74	8573	15	disease	disease	NN
cord-015021-pol2qm74	8573	16	,	,	,
cord-015021-pol2qm74	8573	17	the	the	DT
cord-015021-pol2qm74	8573	18	predictive	predictive	JJ
cord-015021-pol2qm74	8573	19	value	value	NN
cord-015021-pol2qm74	8573	20	of	of	IN
cord-015021-pol2qm74	8573	21	these	these	DT
cord-015021-pol2qm74	8573	22	markers	marker	NNS
cord-015021-pol2qm74	8573	23	was	be	VBD
cord-015021-pol2qm74	8573	24	not	not	RB
cord-015021-pol2qm74	8573	25	better	well	JJR
cord-015021-pol2qm74	8573	26	than	than	IN
cord-015021-pol2qm74	8573	27	the	the	DT
cord-015021-pol2qm74	8573	28	combination	combination	NN
cord-015021-pol2qm74	8573	29	of	of	IN
cord-015021-pol2qm74	8573	30	ctinical	ctinical	JJ
cord-015021-pol2qm74	8573	31	scores	score	NNS
cord-015021-pol2qm74	8573	32	(	(	-LRB-
cord-015021-pol2qm74	8573	33	Ranson	Ranson	NNP
cord-015021-pol2qm74	8573	34	,	,	,
cord-015021-pol2qm74	8573	35	Imrie	Imrie	NNP
cord-015021-pol2qm74	8573	36	,	,	,
cord-015021-pol2qm74	8573	37	APACHE	APACHE	NNP
cord-015021-pol2qm74	8573	38	II	II	NNP
cord-015021-pol2qm74	8573	39	)	)	-RRB-
cord-015021-pol2qm74	8573	40	with	with	IN
cord-015021-pol2qm74	8573	41	GT	GT	NNP
cord-015021-pol2qm74	8573	42	or	or	CC
cord-015021-pol2qm74	8573	43	CRP	CRP	NNP
cord-015021-pol2qm74	8573	44	.	.	.
cord-015021-pol2qm74	8574	1	CONCLUSIONS	conclusion	NNS
cord-015021-pol2qm74	8574	2	:	:	:
cord-015021-pol2qm74	8575	1	Intensive	intensive	JJ
cord-015021-pol2qm74	8575	2	care	care	NN
cord-015021-pol2qm74	8575	3	medicine	medicine	NN
cord-015021-pol2qm74	8575	4	can	can	MD
cord-015021-pol2qm74	8575	5	often	often	RB
cord-015021-pol2qm74	8575	6	control	control	VB
cord-015021-pol2qm74	8575	7	the	the	DT
cord-015021-pol2qm74	8575	8	inital	inital	JJ
cord-015021-pol2qm74	8575	9	shock	shock	NN
cord-015021-pol2qm74	8575	10	situation	situation	NN
cord-015021-pol2qm74	8575	11	in	in	IN
cord-015021-pol2qm74	8575	12	severe	severe	JJ
cord-015021-pol2qm74	8575	13	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8575	14	.	.	.
cord-015021-pol2qm74	8576	1	Thus	thus	RB
cord-015021-pol2qm74	8576	2	.	.	.
cord-015021-pol2qm74	8577	1	only	only	RB
cord-015021-pol2qm74	8577	2	15	15	CD
cord-015021-pol2qm74	8577	3	%	%	NN
cord-015021-pol2qm74	8577	4	of	of	IN
cord-015021-pol2qm74	8577	5	deaths	death	NNS
cord-015021-pol2qm74	8577	6	today	today	NN
cord-015021-pol2qm74	8577	7	occur	occur	VBP
cord-015021-pol2qm74	8577	8	eady	eady	RB
cord-015021-pol2qm74	8577	9	in	in	IN
cord-015021-pol2qm74	8577	10	the	the	DT
cord-015021-pol2qm74	8577	11	course	course	NN
cord-015021-pol2qm74	8577	12	of	of	IN
cord-015021-pol2qm74	8577	13	the	the	DT
cord-015021-pol2qm74	8577	14	disease	disease	NN
cord-015021-pol2qm74	8577	15	,	,	,
cord-015021-pol2qm74	8577	16	whereas	whereas	IN
cord-015021-pol2qm74	8577	17	this	this	DT
cord-015021-pol2qm74	8577	18	percentage	percentage	NN
cord-015021-pol2qm74	8577	19	varied	varied	JJ
cord-015021-pol2qm74	8577	20	between	between	IN
cord-015021-pol2qm74	8577	21	40	40	CD
cord-015021-pol2qm74	8577	22	-	-	SYM
cord-015021-pol2qm74	8577	23	70	70	CD
cord-015021-pol2qm74	8577	24	%	%	NN
cord-015021-pol2qm74	8577	25	just	just	RB
cord-015021-pol2qm74	8577	26	10	10	CD
cord-015021-pol2qm74	8577	27	years	year	NNS
cord-015021-pol2qm74	8577	28	ago	ago	RB
cord-015021-pol2qm74	8577	29	.	.	.
cord-015021-pol2qm74	8578	1	Nowadays	nowadays	RB
cord-015021-pol2qm74	8578	2	,	,	,
cord-015021-pol2qm74	8578	3	most	most	JJS
cord-015021-pol2qm74	8578	4	deaths	death	NNS
cord-015021-pol2qm74	8578	5	are	be	VBP
cord-015021-pol2qm74	8578	6	caused	cause	VBN
cord-015021-pol2qm74	8578	7	by	by	IN
cord-015021-pol2qm74	8578	8	late	late	JJ
cord-015021-pol2qm74	8578	9	septic	septic	JJ
cord-015021-pol2qm74	8578	10	complications	complication	NNS
cord-015021-pol2qm74	8578	11	and	and	CC
cord-015021-pol2qm74	8578	12	multi	multi	JJ
cord-015021-pol2qm74	8578	13	-	-	JJ
cord-015021-pol2qm74	8578	14	organ	organ	JJ
cord-015021-pol2qm74	8578	15	failure	failure	NN
cord-015021-pol2qm74	8578	16	.	.	.
cord-015021-pol2qm74	8579	1	Ranson	Ranson	NNP
cord-015021-pol2qm74	8579	2	-	-	HYPH
cord-015021-pol2qm74	8579	3	and	and	CC
cord-015021-pol2qm74	8579	4	CT	CT	NNP
cord-015021-pol2qm74	8579	5	-	-	HYPH
cord-015021-pol2qm74	8579	6	scores	score	NNS
cord-015021-pol2qm74	8579	7	as	as	RB
cord-015021-pol2qm74	8579	8	well	well	RB
cord-015021-pol2qm74	8579	9	as	as	IN
cord-015021-pol2qm74	8579	10	serum	serum	NN
cord-015021-pol2qm74	8579	11	CRP	CRP	NNP
cord-015021-pol2qm74	8579	12	predict	predict	VBP
cord-015021-pol2qm74	8579	13	a	a	DT
cord-015021-pol2qm74	8579	14	course	course	NN
cord-015021-pol2qm74	8579	15	with	with	IN
cord-015021-pol2qm74	8579	16	systemic	systemic	JJ
cord-015021-pol2qm74	8579	17	complications	complication	NNS
cord-015021-pol2qm74	8579	18	;	;	:
cord-015021-pol2qm74	8579	19	they	-PRON-	PRP
cord-015021-pol2qm74	8579	20	are	be	VBP
cord-015021-pol2qm74	8579	21	less	less	RBR
cord-015021-pol2qm74	8579	22	helpful	helpful	JJ
cord-015021-pol2qm74	8579	23	for	for	IN
cord-015021-pol2qm74	8579	24	prediction	prediction	NN
cord-015021-pol2qm74	8579	25	of	of	IN
cord-015021-pol2qm74	8579	26	sepsis	sepsis	NN
cord-015021-pol2qm74	8579	27	and	and	CC
cord-015021-pol2qm74	8579	28	late	late	JJ
cord-015021-pol2qm74	8579	29	mortality	mortality	NN
cord-015021-pol2qm74	8579	30	.	.	.
cord-015021-pol2qm74	8580	1	It	-PRON-	PRP
cord-015021-pol2qm74	8580	2	is	be	VBZ
cord-015021-pol2qm74	8580	3	doubtful	doubtful	JJ
cord-015021-pol2qm74	8580	4	whether	whether	IN
cord-015021-pol2qm74	8580	5	measurements	measurement	NNS
cord-015021-pol2qm74	8580	6	of	of	IN
cord-015021-pol2qm74	8580	7	cytokines	cytokine	NNS
cord-015021-pol2qm74	8580	8	will	will	MD
cord-015021-pol2qm74	8580	9	help	help	VB
cord-015021-pol2qm74	8580	10	to	to	TO
cord-015021-pol2qm74	8580	11	better	better	RB
cord-015021-pol2qm74	8580	12	predict	predict	VB
cord-015021-pol2qm74	8580	13	the	the	DT
cord-015021-pol2qm74	8580	14	late	late	JJ
cord-015021-pol2qm74	8580	15	outcome	outcome	NN
cord-015021-pol2qm74	8580	16	.	.	.
cord-015021-pol2qm74	8581	1	As	as	IN
cord-015021-pol2qm74	8581	2	yet	yet	RB
cord-015021-pol2qm74	8581	3	,	,	,
cord-015021-pol2qm74	8581	4	only	only	RB
cord-015021-pol2qm74	8581	5	careful	careful	JJ
cord-015021-pol2qm74	8581	6	and	and	CC
cord-015021-pol2qm74	8581	7	continuous	continuous	JJ
cord-015021-pol2qm74	8581	8	monitoring	monitoring	NN
cord-015021-pol2qm74	8581	9	of	of	IN
cord-015021-pol2qm74	8581	10	patients	patient	NNS
cord-015021-pol2qm74	8581	11	(	(	-LRB-
cord-015021-pol2qm74	8581	12	e.g.	e.g.	RB
cord-015021-pol2qm74	8581	13	by	by	IN
cord-015021-pol2qm74	8581	14	APACHE	APACHE	NNP
cord-015021-pol2qm74	8581	15	scores	score	NNS
cord-015021-pol2qm74	8581	16	)	)	-RRB-
cord-015021-pol2qm74	8581	17	may	may	MD
cord-015021-pol2qm74	8581	18	help	help	VB
cord-015021-pol2qm74	8581	19	to	to	TO
cord-015021-pol2qm74	8581	20	early	early	RB
cord-015021-pol2qm74	8581	21	identify	identify	VB
cord-015021-pol2qm74	8581	22	those	those	DT
cord-015021-pol2qm74	8581	23	who	who	WP
cord-015021-pol2qm74	8581	24	develop	develop	VBP
cord-015021-pol2qm74	8581	25	septic	septic	JJ
cord-015021-pol2qm74	8581	26	complications	complication	NNS
cord-015021-pol2qm74	8581	27	and	and	CC
cord-015021-pol2qm74	8581	28	multi	multi	JJ
cord-015021-pol2qm74	8581	29	-	-	JJ
cord-015021-pol2qm74	8581	30	organ	organ	JJ
cord-015021-pol2qm74	8581	31	failure	failure	NN
cord-015021-pol2qm74	8581	32	.	.	.
cord-015021-pol2qm74	8582	1	The	the	DT
cord-015021-pol2qm74	8582	2	classic	classic	JJ
cord-015021-pol2qm74	8582	3	description	description	NN
cord-015021-pol2qm74	8582	4	of	of	IN
cord-015021-pol2qm74	8582	5	severe	severe	JJ
cord-015021-pol2qm74	8582	6	acute	acute	JJ
cord-015021-pol2qm74	8582	7	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8582	8	has	have	VBZ
cord-015021-pol2qm74	8582	9	hinged	hinge	VBN
cord-015021-pol2qm74	8582	10	upon	upon	IN
cord-015021-pol2qm74	8582	11	the	the	DT
cord-015021-pol2qm74	8582	12	release	release	NN
cord-015021-pol2qm74	8582	13	of	of	IN
cord-015021-pol2qm74	8582	14	large	large	JJ
cord-015021-pol2qm74	8582	15	volumes	volume	NNS
cord-015021-pol2qm74	8582	16	of	of	IN
cord-015021-pol2qm74	8582	17	activated	activate	VBN
cord-015021-pol2qm74	8582	18	enzymes	enzyme	NNS
cord-015021-pol2qm74	8582	19	into	into	IN
cord-015021-pol2qm74	8582	20	the	the	DT
cord-015021-pol2qm74	8582	21	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8582	22	cavity	cavity	NN
cord-015021-pol2qm74	8582	23	and	and	CC
cord-015021-pol2qm74	8582	24	thertce	thertce	NNP
cord-015021-pol2qm74	8582	25	the	the	DT
cord-015021-pol2qm74	8582	26	lymphatics	lymphatic	NNS
cord-015021-pol2qm74	8582	27	and	and	CC
cord-015021-pol2qm74	8582	28	blood	blood	NN
cord-015021-pol2qm74	8582	29	stream	stream	NN
cord-015021-pol2qm74	8582	30	.	.	.
cord-015021-pol2qm74	8583	1	These	these	DT
cord-015021-pol2qm74	8583	2	activated	activate	VBN
cord-015021-pol2qm74	8583	3	enzymes	enzyme	NNS
cord-015021-pol2qm74	8583	4	escape	escape	VBP
cord-015021-pol2qm74	8583	5	from	from	IN
cord-015021-pol2qm74	8583	6	the	the	DT
cord-015021-pol2qm74	8583	7	pancreas	pancreas	NN
cord-015021-pol2qm74	8583	8	due	due	IN
cord-015021-pol2qm74	8583	9	to	to	IN
cord-015021-pol2qm74	8583	10	disruption	disruption	NN
cord-015021-pol2qm74	8583	11	of	of	IN
cord-015021-pol2qm74	8583	12	cells	cell	NNS
cord-015021-pol2qm74	8583	13	with	with	IN
cord-015021-pol2qm74	8583	14	associated	associated	JJ
cord-015021-pol2qm74	8583	15	ischaemia	ischaemia	NN
cord-015021-pol2qm74	8583	16	and	and	CC
cord-015021-pol2qm74	8583	17	occasional	occasional	JJ
cord-015021-pol2qm74	8583	18	infarction	infarction	NN
cord-015021-pol2qm74	8583	19	of	of	IN
cord-015021-pol2qm74	8583	20	tissue	tissue	NN
cord-015021-pol2qm74	8583	21	.	.	.
cord-015021-pol2qm74	8584	1	For	for	IN
cord-015021-pol2qm74	8584	2	20	20	CD
cord-015021-pol2qm74	8584	3	to	to	TO
cord-015021-pol2qm74	8584	4	25	25	CD
cord-015021-pol2qm74	8584	5	years	year	NNS
cord-015021-pol2qm74	8584	6	it	-PRON-	PRP
cord-015021-pol2qm74	8584	7	has	have	VBZ
cord-015021-pol2qm74	8584	8	been	be	VBN
cord-015021-pol2qm74	8584	9	postulated	postulate	VBN
cord-015021-pol2qm74	8584	10	that	that	IN
cord-015021-pol2qm74	8584	11	the	the	DT
cord-015021-pol2qm74	8584	12	bocly	bocly	NNP
cord-015021-pol2qm74	8584	13	's	's	POS
cord-015021-pol2qm74	8584	14	defence	defence	NN
cord-015021-pol2qm74	8584	15	system	system	NN
cord-015021-pol2qm74	8584	16	to	to	IN
cord-015021-pol2qm74	8584	17	activated	activate	VBN
cord-015021-pol2qm74	8584	18	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8584	19	enzymes	enzyme	NNS
cord-015021-pol2qm74	8584	20	required	require	VBD
cord-015021-pol2qm74	8584	21	supplementation	supplementation	NN
cord-015021-pol2qm74	8584	22	iu	iu	IN
cord-015021-pol2qm74	8584	23	the	the	DT
cord-015021-pol2qm74	8584	24	form	form	NN
cord-015021-pol2qm74	8584	25	of	of	IN
cord-015021-pol2qm74	8584	26	anti	anti	JJ
cord-015021-pol2qm74	8584	27	-	-	JJ
cord-015021-pol2qm74	8584	28	protease	protease	JJ
cord-015021-pol2qm74	8584	29	support	support	NN
cord-015021-pol2qm74	8584	30	either	either	CC
cord-015021-pol2qm74	8584	31	in	in	IN
cord-015021-pol2qm74	8584	32	the	the	DT
cord-015021-pol2qm74	8584	33	vascular	vascular	JJ
cord-015021-pol2qm74	8584	34	space	space	NN
cord-015021-pol2qm74	8584	35	or	or	CC
cord-015021-pol2qm74	8584	36	in	in	IN
cord-015021-pol2qm74	8584	37	the	the	DT
cord-015021-pol2qm74	8584	38	peritoneal	peritoneal	JJ
cord-015021-pol2qm74	8584	39	cavity	cavity	NN
cord-015021-pol2qm74	8584	40	.	.	.
cord-015021-pol2qm74	8585	1	All	all	DT
cord-015021-pol2qm74	8585	2	controlled	control	VBN
cord-015021-pol2qm74	8585	3	studies	study	NNS
cord-015021-pol2qm74	8585	4	have	have	VBP
cord-015021-pol2qm74	8585	5	shown	show	VBN
cord-015021-pol2qm74	8585	6	that	that	IN
cord-015021-pol2qm74	8585	7	this	this	DT
cord-015021-pol2qm74	8585	8	is	be	VBZ
cord-015021-pol2qm74	8585	9	either	either	CC
cord-015021-pol2qm74	8585	10	impracftcal	impracftcal	JJ
cord-015021-pol2qm74	8585	11	or	or	CC
cord-015021-pol2qm74	8585	12	unnecessary	unnecessary	JJ
cord-015021-pol2qm74	8585	13	.	.	.
cord-015021-pol2qm74	8586	1	Hore	Hore	NNP
cord-015021-pol2qm74	8586	2	recently	recently	RB
cord-015021-pol2qm74	8586	3	release	release	VBZ
cord-015021-pol2qm74	8586	4	of	of	IN
cord-015021-pol2qm74	8586	5	a	a	DT
cord-015021-pol2qm74	8586	6	large	large	JJ
cord-015021-pol2qm74	8586	7	number	number	NN
cord-015021-pol2qm74	8586	8	of	of	IN
cord-015021-pol2qm74	8586	9	cytokines	cytokine	NNS
cord-015021-pol2qm74	8586	10	from	from	IN
cord-015021-pol2qm74	8586	11	monocytes	monocyte	NNS
cord-015021-pol2qm74	8586	12	,	,	,
cord-015021-pol2qm74	8586	13	macrophages	macrophage	NNS
cord-015021-pol2qm74	8586	14	and	and	CC
cord-015021-pol2qm74	8586	15	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	8586	16	have	have	VBP
cord-015021-pol2qm74	8586	17	been	be	VBN
cord-015021-pol2qm74	8586	18	considered	consider	VBN
cord-015021-pol2qm74	8586	19	to	to	TO
cord-015021-pol2qm74	8586	20	be	be	VB
cord-015021-pol2qm74	8586	21	harmful	harmful	JJ
cord-015021-pol2qm74	8586	22	to	to	IN
cord-015021-pol2qm74	8586	23	the	the	DT
cord-015021-pol2qm74	8586	24	body	body	NN
cord-015021-pol2qm74	8586	25	and	and	CC
cord-015021-pol2qm74	8586	26	various	various	JJ
cord-015021-pol2qm74	8586	27	agent~	agent~	NNP
cord-015021-pol2qm74	8586	28	which	which	WDT
cord-015021-pol2qm74	8586	29	oppose	oppose	VBP
cord-015021-pol2qm74	8586	30	the	the	DT
cord-015021-pol2qm74	8586	31	action	action	NN
cord-015021-pol2qm74	8586	32	of	of	IN
cord-015021-pol2qm74	8586	33	TNF	TNF	NNP
cord-015021-pol2qm74	8586	34	alpha	alpha	NN
cord-015021-pol2qm74	8586	35	,	,	,
cord-015021-pol2qm74	8586	36	PAF	PAF	NNP
cord-015021-pol2qm74	8586	37	and	and	CC
cord-015021-pol2qm74	8586	38	similar	similar	JJ
cord-015021-pol2qm74	8586	39	cytokines	cytokine	NNS
cord-015021-pol2qm74	8586	40	are	be	VBP
cord-015021-pol2qm74	8586	41	being	be	VBG
cord-015021-pol2qm74	8586	42	examined	examine	VBN
cord-015021-pol2qm74	8586	43	in	in	IN
cord-015021-pol2qm74	8586	44	experimental	experimental	JJ
cord-015021-pol2qm74	8586	45	anim	anim	NN
cord-015021-pol2qm74	8586	46	~	~	NFP
cord-015021-pol2qm74	8586	47	is	be	VBZ
cord-015021-pol2qm74	8586	48	and	and	CC
cord-015021-pol2qm74	8586	49	certain	certain	JJ
cord-015021-pol2qm74	8586	50	clinical	clinical	JJ
cord-015021-pol2qm74	8586	51	trials	trial	NNS
cord-015021-pol2qm74	8586	52	,	,	,
cord-015021-pol2qm74	8586	53	It	-PRON-	PRP
cord-015021-pol2qm74	8586	54	has	have	VBZ
cord-015021-pol2qm74	8586	55	clearly	clearly	RB
cord-015021-pol2qm74	8586	56	been	be	VBN
cord-015021-pol2qm74	8586	57	shown	show	VBN
cord-015021-pol2qm74	8586	58	that	that	IN
cord-015021-pol2qm74	8586	59	higher	high	JJR
cord-015021-pol2qm74	8586	60	levels	level	NNS
cord-015021-pol2qm74	8586	61	of	of	IN
cord-015021-pol2qm74	8586	62	cytokines	cytokine	NNS
cord-015021-pol2qm74	8586	63	are	be	VBP
cord-015021-pol2qm74	8586	64	released	release	VBN
cord-015021-pol2qm74	8586	65	in	in	IN
cord-015021-pol2qm74	8586	66	the	the	DT
cord-015021-pol2qm74	8586	67	patients	patient	NNS
cord-015021-pol2qm74	8586	68	with	with	IN
cord-015021-pol2qm74	8586	69	objectively	objectively	RB
cord-015021-pol2qm74	8586	70	graded	grade	VBN
cord-015021-pol2qm74	8586	71	severe	severe	JJ
cord-015021-pol2qm74	8586	72	acute	acute	JJ
cord-015021-pol2qm74	8586	73	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8586	74	than	than	IN
cord-015021-pol2qm74	8586	75	in	in	IN
cord-015021-pol2qm74	8586	76	those	those	DT
cord-015021-pol2qm74	8586	77	with	with	IN
cord-015021-pol2qm74	8586	78	milder	mild	JJR
cord-015021-pol2qm74	8586	79	disease	disease	NN
cord-015021-pol2qm74	8586	80	.	.	.
cord-015021-pol2qm74	8587	1	We	-PRON-	PRP
cord-015021-pol2qm74	8587	2	now	now	RB
cord-015021-pol2qm74	8587	3	seem	seem	VBP
cord-015021-pol2qm74	8587	4	to	to	TO
cord-015021-pol2qm74	8587	5	be	be	VB
cord-015021-pol2qm74	8587	6	moving	move	VBG
cord-015021-pol2qm74	8587	7	into	into	IN
cord-015021-pol2qm74	8587	8	an	an	DT
cord-015021-pol2qm74	8587	9	exciting	exciting	JJ
cord-015021-pol2qm74	8587	10	phase	phase	NN
cord-015021-pol2qm74	8587	11	of	of	IN
cord-015021-pol2qm74	8587	12	potentially	potentially	RB
cord-015021-pol2qm74	8587	13	beneficial	beneficial	JJ
cord-015021-pol2qm74	8587	14	therapy	therapy	NN
cord-015021-pol2qm74	8587	15	in	in	IN
cord-015021-pol2qm74	8587	16	acute	acute	JJ
cord-015021-pol2qm74	8587	17	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8587	18	which	which	WDT
cord-015021-pol2qm74	8587	19	has	have	VBZ
cord-015021-pol2qm74	8587	20	had	have	VBN
cord-015021-pol2qm74	8587	21	no	no	DT
cord-015021-pol2qm74	8587	22	specific	specific	JJ
cord-015021-pol2qm74	8587	23	effective	effective	JJ
cord-015021-pol2qm74	8587	24	therapy	therapy	NN
cord-015021-pol2qm74	8587	25	through	through	IN
cord-015021-pol2qm74	8587	26	studies	study	NNS
cord-015021-pol2qm74	8587	27	utilising	utilise	VBG
cord-015021-pol2qm74	8587	28	aprotinin	aprotinin	NNP
cord-015021-pol2qm74	8587	29	,	,	,
cord-015021-pol2qm74	8587	30	gabexate	gabexate	NNP
cord-015021-pol2qm74	8587	31	mesilate	mesilate	NNP
cord-015021-pol2qm74	8587	32	and	and	CC
cord-015021-pol2qm74	8587	33	fresh	fresh	JJ
cord-015021-pol2qm74	8587	34	frozen	frozen	JJ
cord-015021-pol2qm74	8587	35	plasma	plasma	NN
cord-015021-pol2qm74	8587	36	.	.	.
cord-015021-pol2qm74	8588	1	Inflammation	inflammation	NN
cord-015021-pol2qm74	8588	2	cascades	cascade	NNS
cord-015021-pol2qm74	8588	3	may	may	MD
cord-015021-pol2qm74	8588	4	play	play	VB
cord-015021-pol2qm74	8588	5	a	a	DT
cord-015021-pol2qm74	8588	6	role	role	NN
cord-015021-pol2qm74	8588	7	in	in	IN
cord-015021-pol2qm74	8588	8	the	the	DT
cord-015021-pol2qm74	8588	9	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8588	10	of	of	IN
cord-015021-pol2qm74	8588	11	acute	acute	JJ
cord-015021-pol2qm74	8588	12	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8588	13	.	.	.
cord-015021-pol2qm74	8589	1	To	to	TO
cord-015021-pol2qm74	8589	2	evaluate	evaluate	VB
cord-015021-pol2qm74	8589	3	the	the	DT
cord-015021-pol2qm74	8589	4	status	status	NN
cord-015021-pol2qm74	8589	5	of	of	IN
cord-015021-pol2qm74	8589	6	the	the	DT
cord-015021-pol2qm74	8589	7	cellular	cellular	JJ
cord-015021-pol2qm74	8589	8	immune	immune	JJ
cord-015021-pol2qm74	8589	9	system	system	NN
cord-015021-pol2qm74	8589	10	we	-PRON-	PRP
cord-015021-pol2qm74	8589	11	examined	examine	VBD
cord-015021-pol2qm74	8589	12	serum	serum	NN
cord-015021-pol2qm74	8589	13	concentrations	concentration	NNS
cord-015021-pol2qm74	8589	14	of	of	IN
cord-015021-pol2qm74	8589	15	immune	immune	JJ
cord-015021-pol2qm74	8589	16	activation	activation	NN
cord-015021-pol2qm74	8589	17	markers	marker	NNS
cord-015021-pol2qm74	8589	18	in	in	IN
cord-015021-pol2qm74	8589	19	24	24	CD
cord-015021-pol2qm74	8589	20	patients	patient	NNS
cord-015021-pol2qm74	8589	21	with	with	IN
cord-015021-pol2qm74	8589	22	acute	acute	JJ
cord-015021-pol2qm74	8589	23	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8589	24	(	(	-LRB-
cord-015021-pol2qm74	8589	25	14	14	CD
cord-015021-pol2qm74	8589	26	males	male	NNS
cord-015021-pol2qm74	8589	27	,	,	,
cord-015021-pol2qm74	8589	28	10	10	CD
cord-015021-pol2qm74	8589	29	females	female	NNS
cord-015021-pol2qm74	8589	30	;	;	:
cord-015021-pol2qm74	8589	31	median	median	JJ
cord-015021-pol2qm74	8589	32	age	age	NN
cord-015021-pol2qm74	8589	33	:	:	:
cord-015021-pol2qm74	8589	34	56	56	CD
cord-015021-pol2qm74	8589	35	years	year	NNS
cord-015021-pol2qm74	8589	36	,	,	,
cord-015021-pol2qm74	8589	37	range	range	NN
cord-015021-pol2qm74	8589	38	:	:	:
cord-015021-pol2qm74	8589	39	32	32	CD
cord-015021-pol2qm74	8589	40	-	-	SYM
cord-015021-pol2qm74	8589	41	81	81	CD
cord-015021-pol2qm74	8589	42	years	year	NNS
cord-015021-pol2qm74	8589	43	)	)	-RRB-
cord-015021-pol2qm74	8589	44	.	.	.
cord-015021-pol2qm74	8590	1	Concentrations	concentration	NNS
cord-015021-pol2qm74	8590	2	of	of	IN
cord-015021-pol2qm74	8590	3	neopterin	neopterin	NNP
cord-015021-pol2qm74	8590	4	,	,	,
cord-015021-pol2qm74	8590	5	serum	serum	NN
cord-015021-pol2qm74	8590	6	soluble	soluble	JJ
cord-015021-pol2qm74	8590	7	tumor	tumor	NN
cord-015021-pol2qm74	8590	8	necrosis	necrosis	NN
cord-015021-pol2qm74	8590	9	factor	factor	NN
cord-015021-pol2qm74	8590	10	receptor	receptor	NN
cord-015021-pol2qm74	8590	11	(	(	-LRB-
cord-015021-pol2qm74	8590	12	sTNF	stnf	NN
cord-015021-pol2qm74	8590	13	-	-	HYPH
cord-015021-pol2qm74	8590	14	R	r	NN
cord-015021-pol2qm74	8590	15	)	)	-RRB-
cord-015021-pol2qm74	8590	16	and	and	CC
cord-015021-pol2qm74	8590	17	serum	serum	NN
cord-015021-pol2qm74	8590	18	soluble	soluble	JJ
cord-015021-pol2qm74	8590	19	intercellular	intercellular	JJ
cord-015021-pol2qm74	8590	20	adhesion	adhesion	NN
cord-015021-pol2qm74	8590	21	molecule	molecule	NN
cord-015021-pol2qm74	8590	22	type	type	NN
cord-015021-pol2qm74	8590	23	1	1	CD
cord-015021-pol2qm74	8590	24	(	(	-LRB-
cord-015021-pol2qm74	8590	25	slCAM-1	slCAM-1	NNP
cord-015021-pol2qm74	8590	26	)	)	-RRB-
cord-015021-pol2qm74	8590	27	were	be	VBD
cord-015021-pol2qm74	8590	28	determined	determine	VBN
cord-015021-pol2qm74	8590	29	using	use	VBG
cord-015021-pol2qm74	8590	30	immunoassays	immunoassay	NNS
cord-015021-pol2qm74	8590	31	(	(	-LRB-
cord-015021-pol2qm74	8590	32	Henning	Henning	NNP
cord-015021-pol2qm74	8590	33	,	,	,
cord-015021-pol2qm74	8590	34	Bender	Bender	NNP
cord-015021-pol2qm74	8590	35	,	,	,
cord-015021-pol2qm74	8590	36	T	T	NNP
cord-015021-pol2qm74	8590	37	Cell	Cell	NNP
cord-015021-pol2qm74	8590	38	Sciences	Sciences	NNPS
cord-015021-pol2qm74	8590	39	)	)	-RRB-
cord-015021-pol2qm74	8590	40	.	.	.
cord-015021-pol2qm74	8591	1	13/14	13/14	CD
cord-015021-pol2qm74	8591	2	had	have	VBD
cord-015021-pol2qm74	8591	3	increased	increase	VBN
cord-015021-pol2qm74	8591	4	concentrations	concentration	NNS
cord-015021-pol2qm74	8591	5	of	of	IN
cord-015021-pol2qm74	8591	6	sTNF	stnf	NN
cord-015021-pol2qm74	8591	7	-	-	HYPH
cord-015021-pol2qm74	8591	8	R	r	NN
cord-015021-pol2qm74	8591	9	compared	compare	VBN
cord-015021-pol2qm74	8591	10	to	to	IN
cord-015021-pol2qm74	8591	11	the	the	DT
cord-015021-pol2qm74	8591	12	75th	75th	JJ
cord-015021-pol2qm74	8591	13	percentile	percentile	NN
cord-015021-pol2qm74	8591	14	obtained	obtain	VBN
cord-015021-pol2qm74	8591	15	in	in	IN
cord-015021-pol2qm74	8591	16	healthy	healthy	JJ
cord-015021-pol2qm74	8591	17	controls	control	NNS
cord-015021-pol2qm74	8591	18	(	(	-LRB-
cord-015021-pol2qm74	8591	19	>	>	NFP
cord-015021-pol2qm74	8591	20	4.2	4.2	CD
cord-015021-pol2qm74	8591	21	ng	ng	NNP
cord-015021-pol2qm74	8591	22	/	/	SYM
cord-015021-pol2qm74	8591	23	ml	ml	NN
cord-015021-pol2qm74	8591	24	)	)	-RRB-
cord-015021-pol2qm74	8591	25	,	,	,
cord-015021-pol2qm74	8591	26	and	and	CC
cord-015021-pol2qm74	8591	27	9/24	9/24	CD
cord-015021-pol2qm74	8591	28	patients	patient	NNS
cord-015021-pol2qm74	8591	29	had	have	VBD
cord-015021-pol2qm74	8591	30	increased	increase	VBN
cord-015021-pol2qm74	8591	31	neopterin	neopterin	NNP
cord-015021-pol2qm74	8591	32	(	(	-LRB-
cord-015021-pol2qm74	8591	33	>	>	NFP
cord-015021-pol2qm74	8591	34	8.7	8.7	CD
cord-015021-pol2qm74	8591	35	nmol	nmol	NN
cord-015021-pol2qm74	8591	36	/	/	,
cord-015021-pol2qm74	8591	37	I	i	NN
cord-015021-pol2qm74	8591	38	)	)	-RRB-
cord-015021-pol2qm74	8591	39	,	,	,
cord-015021-pol2qm74	8591	40	9/24	9/24	CD
cord-015021-pol2qm74	8591	41	presented	present	VBN
cord-015021-pol2qm74	8591	42	with	with	IN
cord-015021-pol2qm74	8591	43	elevated	elevate	VBN
cord-015021-pol2qm74	8591	44	slCAM-1	slCAM-1	NNP
cord-015021-pol2qm74	8591	45	(	(	-LRB-
cord-015021-pol2qm74	8591	46	>	>	XX
cord-015021-pol2qm74	8592	1	440	440	CD
cord-015021-pol2qm74	8592	2	U	u	NN
cord-015021-pol2qm74	8592	3	/	/	SYM
cord-015021-pol2qm74	8592	4	I	i	NN
cord-015021-pol2qm74	8592	5	)	)	-RRB-
cord-015021-pol2qm74	8592	6	.	.	.
cord-015021-pol2qm74	8593	1	All	all	DT
cord-015021-pol2qm74	8593	2	patients	patient	NNS
cord-015021-pol2qm74	8593	3	with	with	IN
cord-015021-pol2qm74	8593	4	increased	increase	VBN
cord-015021-pol2qm74	8593	5	neopterin	neopterin	NNP
cord-015021-pol2qm74	8593	6	also	also	RB
cord-015021-pol2qm74	8593	7	had	have	VBD
cord-015021-pol2qm74	8593	8	increased	increase	VBN
cord-015021-pol2qm74	8593	9	sTNF	stnf	NN
cord-015021-pol2qm74	8593	10	-	-	HYPH
cord-015021-pol2qm74	8593	11	R	r	NN
cord-015021-pol2qm74	8593	12	,	,	,
cord-015021-pol2qm74	8594	1	4	4	CD
cord-015021-pol2qm74	8594	2	patients	patient	NNS
cord-015021-pol2qm74	8594	3	had	have	VBD
cord-015021-pol2qm74	8594	4	concentrations	concentration	NNS
cord-015021-pol2qm74	8594	5	of	of	IN
cord-015021-pol2qm74	8594	6	all	all	DT
cord-015021-pol2qm74	8594	7	three	three	CD
cord-015021-pol2qm74	8594	8	markers	marker	NNS
cord-015021-pol2qm74	8594	9	outside	outside	IN
cord-015021-pol2qm74	8594	10	the	the	DT
cord-015021-pol2qm74	8594	11	normal	normal	JJ
cord-015021-pol2qm74	8594	12	range	range	NN
cord-015021-pol2qm74	8594	13	.	.	.
cord-015021-pol2qm74	8595	1	There	there	EX
cord-015021-pol2qm74	8595	2	existed	exist	VBD
cord-015021-pol2qm74	8595	3	a	a	DT
cord-015021-pol2qm74	8595	4	significant	significant	JJ
cord-015021-pol2qm74	8595	5	correlation	correlation	NN
cord-015021-pol2qm74	8595	6	between	between	IN
cord-015021-pol2qm74	8595	7	neopterin	neopterin	NNP
cord-015021-pol2qm74	8595	8	and	and	CC
cord-015021-pol2qm74	8595	9	sTNF	stnf	NN
cord-015021-pol2qm74	8595	10	-	-	HYPH
cord-015021-pol2qm74	8595	11	R	r	NN
cord-015021-pol2qm74	8595	12	(	(	-LRB-
cord-015021-pol2qm74	8595	13	rs	rs	NN
cord-015021-pol2qm74	8595	14	=	=	SYM
cord-015021-pol2qm74	8595	15	0.728	0.728	CD
cord-015021-pol2qm74	8595	16	,	,	,
cord-015021-pol2qm74	8595	17	p	p	NN
cord-015021-pol2qm74	8595	18	<	<	XX
cord-015021-pol2qm74	8595	19	0.001	0.001	CD
cord-015021-pol2qm74	8595	20	)	)	-RRB-
cord-015021-pol2qm74	8595	21	.	.	.
cord-015021-pol2qm74	8596	1	Weak	weak	JJ
cord-015021-pol2qm74	8596	2	associations	association	NNS
cord-015021-pol2qm74	8596	3	between	between	IN
cord-015021-pol2qm74	8596	4	age	age	NN
cord-015021-pol2qm74	8596	5	and	and	CC
cord-015021-pol2qm74	8596	6	sTNF	stnf	NN
cord-015021-pol2qm74	8596	7	-	-	HYPH
cord-015021-pol2qm74	8596	8	R	r	NN
cord-015021-pol2qm74	8596	9	(	(	-LRB-
cord-015021-pol2qm74	8596	10	rs=0.435	rs=0.435	NNS
cord-015021-pol2qm74	8596	11	,	,	,
cord-015021-pol2qm74	8596	12	p	p	NN
cord-015021-pol2qm74	8596	13	=	=	SYM
cord-015021-pol2qm74	8596	14	O.05	o.05	NN
cord-015021-pol2qm74	8596	15	)	)	-RRB-
cord-015021-pol2qm74	8596	16	or	or	CC
cord-015021-pol2qm74	8596	17	neopterin	neopterin	NNP
cord-015021-pol2qm74	8596	18	(	(	-LRB-
cord-015021-pol2qm74	8596	19	rs=0.456	rs=0.456	NNP
cord-015021-pol2qm74	8596	20	,	,	,
cord-015021-pol2qm74	8596	21	p	p	NN
cord-015021-pol2qm74	8596	22	=	=	SYM
cord-015021-pol2qm74	8596	23	0.044	0.044	CD
cord-015021-pol2qm74	8596	24	)	)	-RRB-
cord-015021-pol2qm74	8596	25	were	be	VBD
cord-015021-pol2qm74	8596	26	also	also	RB
cord-015021-pol2qm74	8596	27	found	find	VBN
cord-015021-pol2qm74	8596	28	.	.	.
cord-015021-pol2qm74	8597	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8597	2	results	result	NNS
cord-015021-pol2qm74	8597	3	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	8597	4	activation	activation	NN
cord-015021-pol2qm74	8597	5	of	of	IN
cord-015021-pol2qm74	8597	6	the	the	DT
cord-015021-pol2qm74	8597	7	cell	cell	NN
cord-015021-pol2qm74	8597	8	-	-	HYPH
cord-015021-pol2qm74	8597	9	mediated	mediate	VBN
cord-015021-pol2qm74	8597	10	immune	immune	JJ
cord-015021-pol2qm74	8597	11	system	system	NN
cord-015021-pol2qm74	8597	12	taking	take	VBG
cord-015021-pol2qm74	8597	13	place	place	NN
cord-015021-pol2qm74	8597	14	in	in	IN
cord-015021-pol2qm74	8597	15	a	a	DT
cord-015021-pol2qm74	8597	16	sub	sub	NN
cord-015021-pol2qm74	8597	17	-	-	JJ
cord-015021-pol2qm74	8597	18	group	group	NN
cord-015021-pol2qm74	8597	19	of	of	IN
cord-015021-pol2qm74	8597	20	patients	patient	NNS
cord-015021-pol2qm74	8597	21	with	with	IN
cord-015021-pol2qm74	8597	22	acute	acute	JJ
cord-015021-pol2qm74	8597	23	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8597	24	.	.	.
cord-015021-pol2qm74	8598	1	The	the	DT
cord-015021-pol2qm74	8598	2	finding	finding	NN
cord-015021-pol2qm74	8598	3	of	of	IN
cord-015021-pol2qm74	8598	4	increased	increase	VBN
cord-015021-pol2qm74	8598	5	neopterin	neopterin	JJ
cord-015021-pol2qm74	8598	6	and	and	CC
cord-015021-pol2qm74	8598	7	sTNF	stnf	NN
cord-015021-pol2qm74	8598	8	-	-	HYPH
cord-015021-pol2qm74	8598	9	R	r	NN
cord-015021-pol2qm74	8598	10	levels	level	NNS
cord-015021-pol2qm74	8598	11	implies	imply	VBZ
cord-015021-pol2qm74	8598	12	that	that	IN
cord-015021-pol2qm74	8598	13	activated	activate	VBN
cord-015021-pol2qm74	8598	14	monocytes	monocyte	NNS
cord-015021-pol2qm74	8598	15	/	/	SYM
cord-015021-pol2qm74	8598	16	macrophages	macrophage	NNS
cord-015021-pol2qm74	8598	17	are	be	VBP
cord-015021-pol2qm74	8598	18	involved	involve	VBN
cord-015021-pol2qm74	8598	19	in	in	IN
cord-015021-pol2qm74	8598	20	the	the	DT
cord-015021-pol2qm74	8598	21	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8598	22	of	of	IN
cord-015021-pol2qm74	8598	23	the	the	DT
cord-015021-pol2qm74	8598	24	disease	disease	NN
cord-015021-pol2qm74	8598	25	.	.	.
cord-015021-pol2qm74	8599	1	Further	further	JJ
cord-015021-pol2qm74	8599	2	data	datum	NNS
cord-015021-pol2qm74	8599	3	are	be	VBP
cord-015021-pol2qm74	8599	4	necessary	necessary	JJ
cord-015021-pol2qm74	8599	5	to	to	TO
cord-015021-pol2qm74	8599	6	evaluate	evaluate	VB
cord-015021-pol2qm74	8599	7	potential	potential	JJ
cord-015021-pol2qm74	8599	8	associations	association	NNS
cord-015021-pol2qm74	8599	9	between	between	IN
cord-015021-pol2qm74	8599	10	changes	change	NNS
cord-015021-pol2qm74	8599	11	of	of	IN
cord-015021-pol2qm74	8599	12	marker	marker	NN
cord-015021-pol2qm74	8599	13	concent	concent	NN
cord-015021-pol2qm74	8599	14	-	-	HYPH
cord-015021-pol2qm74	8599	15	rations	ration	NNS
cord-015021-pol2qm74	8599	16	and	and	CC
cord-015021-pol2qm74	8599	17	the	the	DT
cord-015021-pol2qm74	8599	18	course	course	NN
cord-015021-pol2qm74	8599	19	of	of	IN
cord-015021-pol2qm74	8599	20	the	the	DT
cord-015021-pol2qm74	8599	21	disease	disease	NN
cord-015021-pol2qm74	8599	22	.	.	.
cord-015021-pol2qm74	8600	1	Pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8600	2	injury	injury	NN
cord-015021-pol2qm74	8600	3	after	after	IN
cord-015021-pol2qm74	8600	4	heart	heart	NN
cord-015021-pol2qm74	8600	5	surgery	surgery	NN
cord-015021-pol2qm74	8600	6	was	be	VBD
cord-015021-pol2qm74	8600	7	reported	report	VBN
cord-015021-pol2qm74	8600	8	as	as	RB
cord-015021-pol2qm74	8600	9	soon	soon	RB
cord-015021-pol2qm74	8600	10	as	as	IN
cord-015021-pol2qm74	8600	11	1970	1970	CD
cord-015021-pol2qm74	8600	12	(	(	-LRB-
cord-015021-pol2qm74	8600	13	1,2	1,2	CD
cord-015021-pol2qm74	8600	14	)	)	-RRB-
cord-015021-pol2qm74	8600	15	and	and	CC
cord-015021-pol2qm74	8600	16	characterized	characterize	VBN
cord-015021-pol2qm74	8600	17	by	by	IN
cord-015021-pol2qm74	8600	18	increased	increase	VBN
cord-015021-pol2qm74	8600	19	serum	serum	NN
cord-015021-pol2qm74	8600	20	or	or	CC
cord-015021-pol2qm74	8600	21	urine	urine	NN
cord-015021-pol2qm74	8600	22	amylase	amylase	NN
cord-015021-pol2qm74	8600	23	levels	level	NNS
cord-015021-pol2qm74	8600	24	(	(	-LRB-
cord-015021-pol2qm74	8600	25	in	in	IN
cord-015021-pol2qm74	8600	26	about	about	RB
cord-015021-pol2qm74	8600	27	33	33	CD
cord-015021-pol2qm74	8600	28	%	%	NN
cord-015021-pol2qm74	8600	29	of	of	IN
cord-015021-pol2qm74	8600	30	patients	patient	NNS
cord-015021-pol2qm74	8600	31	)	)	-RRB-
cord-015021-pol2qm74	8600	32	in	in	IN
cord-015021-pol2qm74	8600	33	the	the	DT
cord-015021-pol2qm74	8600	34	5	5	CD
cord-015021-pol2qm74	8600	35	fi	fi	NN
cord-015021-pol2qm74	8600	36	~	~	NN
cord-015021-pol2qm74	8600	37	t	t	NNP
cord-015021-pol2qm74	8600	38	postoperafi	postoperafi	NNP
cord-015021-pol2qm74	8600	39	.	.	.
cord-015021-pol2qm74	8601	1	'	'	``
cord-015021-pol2qm74	8601	2	ve	ve	NNP
cord-015021-pol2qm74	8601	3	days	day	NNS
cord-015021-pol2qm74	8601	4	.	.	.
cord-015021-pol2qm74	8602	1	This	this	DT
cord-015021-pol2qm74	8602	2	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8602	3	injury	injury	NN
cord-015021-pol2qm74	8602	4	,	,	,
cord-015021-pol2qm74	8602	5	which	which	WDT
cord-015021-pol2qm74	8602	6	sometimes	sometimes	RB
cord-015021-pol2qm74	8602	7	led	lead	VBD
cord-015021-pol2qm74	8602	8	to	to	IN
cord-015021-pol2qm74	8602	9	acute	acute	JJ
cord-015021-pol2qm74	8602	10	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8602	11	,	,	,
cord-015021-pol2qm74	8602	12	was	be	VBD
cord-015021-pol2qm74	8602	13	atreaay	atreaay	NNP
cord-015021-pol2qm74	8602	14	at	at	IN
cord-015021-pol2qm74	8602	15	~	~	NFP
cord-015021-pol2qm74	8602	16	buted	bute	VBN
cord-015021-pol2qm74	8602	17	to	to	IN
cord-015021-pol2qm74	8602	18	inappropriate	inappropriate	JJ
cord-015021-pol2qm74	8602	19	perfusion	perfusion	NN
cord-015021-pol2qm74	8602	20	of	of	IN
cord-015021-pol2qm74	8602	21	this	this	DT
cord-015021-pol2qm74	8602	22	organ	organ	NN
cord-015021-pol2qm74	8602	23	.	.	.
cord-015021-pol2qm74	8603	1	In	in	IN
cord-015021-pol2qm74	8603	2	the	the	DT
cord-015021-pol2qm74	8603	3	198ffs	198ffs	CD
cord-015021-pol2qm74	8603	4	,	,	,
cord-015021-pol2qm74	8603	5	3	3	CD
cord-015021-pol2qm74	8603	6	studies	study	NNS
cord-015021-pol2qm74	8603	7	were	be	VBD
cord-015021-pol2qm74	8603	8	published	publish	VBN
cord-015021-pol2qm74	8603	9	dealing	deal	VBG
cord-015021-pol2qm74	8603	10	with	with	IN
cord-015021-pol2qm74	8603	11	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8603	12	suffering	suffering	NN
cord-015021-pol2qm74	8603	13	alter	alter	VB
cord-015021-pol2qm74	8603	14	heart	heart	NN
cord-015021-pol2qm74	8603	15	surgery	surgery	NN
cord-015021-pol2qm74	8603	16	,	,	,
cord-015021-pol2qm74	8603	17	in	in	IN
cord-015021-pol2qm74	8603	18	large	large	JJ
cord-015021-pol2qm74	8603	19	series	series	NN
cord-015021-pol2qm74	8603	20	of	of	IN
cord-015021-pol2qm74	8603	21	patients	patient	NNS
cord-015021-pol2qm74	8603	22	,	,	,
cord-015021-pol2qm74	8603	23	concluding	conclude	VBG
cord-015021-pol2qm74	8603	24	~n	~n	NNP
cord-015021-pol2qm74	8604	1	~at	~at	NNP
cord-015021-pol2qm74	8604	2	panc	panc	NNP
cord-015021-pol2qm74	8604	3	~	~	NFP
cord-015021-pol2qm74	8604	4	a	a	LS
cord-015021-pol2qm74	8604	5	~	~	NFP
cord-015021-pol2qm74	8604	6	c	c	NN
cord-015021-pol2qm74	8604	7	injury	injury	NN
cord-015021-pol2qm74	8604	8	(	(	-LRB-
cord-015021-pol2qm74	8604	9	with	with	IN
cord-015021-pol2qm74	8604	10	a	a	DT
cord-015021-pol2qm74	8604	11	low	low	JJ
cord-015021-pol2qm74	8604	12	incidence	incidence	NN
cord-015021-pol2qm74	8604	13	of	of	IN
cord-015021-pol2qm74	8604	14	pancreatifis	pancreatifis	NN
cord-015021-pol2qm74	8604	15	)	)	-RRB-
cord-015021-pol2qm74	8604	16	is	be	VBZ
cord-015021-pol2qm74	8604	17	more	more	RBR
cord-015021-pol2qm74	8604	18	common	common	JJ
cord-015021-pol2qm74	8604	19	than	than	IN
cord-015021-pol2qm74	8604	20	previously	previously	RB
cord-015021-pol2qm74	8604	21	recognized	recognize	VBN
cord-015021-pol2qm74	8604	22	and	and	CC
cord-015021-pol2qm74	8604	23	is	be	VBZ
cord-015021-pol2qm74	8604	24	a	a	DT
cord-015021-pol2qm74	8604	25	potential	potential	JJ
cord-015021-pol2qm74	8604	26	source	source	NN
cord-015021-pol2qm74	8604	27	of	of	IN
cord-015021-pol2qm74	8604	28	complication	complication	NN
cord-015021-pol2qm74	8604	29	after	after	IN
cord-015021-pol2qm74	8604	30	camliac	camliac	NNP
cord-015021-pol2qm74	8604	31	surgery	surgery	NN
cord-015021-pol2qm74	8604	32	(	(	-LRB-
cord-015021-pol2qm74	8604	33	3	3	CD
cord-015021-pol2qm74	8604	34	,	,	,
cord-015021-pol2qm74	8604	35	4	4	CD
cord-015021-pol2qm74	8604	36	,	,	,
cord-015021-pol2qm74	8604	37	5	5	CD
cord-015021-pol2qm74	8604	38	)	)	-RRB-
cord-015021-pol2qm74	8604	39	.	.	.
cord-015021-pol2qm74	8605	1	In	in	IN
cord-015021-pol2qm74	8605	2	a	a	DT
cord-015021-pol2qm74	8605	3	recent	recent	JJ
cord-015021-pol2qm74	8605	4	study	study	NN
cord-015021-pol2qm74	8605	5	(	(	-LRB-
cord-015021-pol2qm74	8605	6	6	6	CD
cord-015021-pol2qm74	8605	7	)	)	-RRB-
cord-015021-pol2qm74	8605	8	,	,	,
cord-015021-pol2qm74	8605	9	evidence	evidence	NN
cord-015021-pol2qm74	8605	10	of	of	IN
cord-015021-pol2qm74	8605	11	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8605	12	cellular	cellular	JJ
cord-015021-pol2qm74	8605	13	injury	injury	NN
cord-015021-pol2qm74	8605	14	was	be	VBD
cord-015021-pol2qm74	8605	15	found	find	VBN
cord-015021-pol2qm74	8605	16	in	in	IN
cord-015021-pol2qm74	8605	17	80	80	CD
cord-015021-pol2qm74	8605	18	out	out	IN
cord-015021-pol2qm74	8605	19	of	of	IN
cord-015021-pol2qm74	8605	20	300	300	CD
cord-015021-pol2qm74	8605	21	patients	patient	NNS
cord-015021-pol2qm74	8605	22	undergoing	undergo	VBG
cord-015021-pol2qm74	8605	23	cardiac	cardiac	JJ
cord-015021-pol2qm74	8605	24	surgery	surgery	NN
cord-015021-pol2qm74	8605	25	,	,	,
cord-015021-pol2qm74	8605	26	with	with	IN
cord-015021-pol2qm74	8605	27	22	22	CD
cord-015021-pol2qm74	8605	28	out	out	IN
cord-015021-pol2qm74	8605	29	of	of	IN
cord-015021-pol2qm74	8605	30	these	these	DT
cord-015021-pol2qm74	8605	31	80	80	CD
cord-015021-pol2qm74	8605	32	patients	patient	NNS
cord-015021-pol2qm74	8605	33	presenting	present	VBG
cord-015021-pol2qm74	8605	34	abdominal	abdominal	JJ
cord-015021-pol2qm74	8605	35	signs	sign	NNS
cord-015021-pol2qm74	8605	36	or	or	CC
cord-015021-pol2qm74	8605	37	symptoms	symptom	NNS
cord-015021-pol2qm74	8605	38	and	and	CC
cord-015021-pol2qm74	8605	39	3	3	CD
cord-015021-pol2qm74	8605	40	developing	develop	VBG
cord-015021-pol2qm74	8605	41	severe	severe	JJ
cord-015021-pol2qm74	8605	42	pancreafitis	pancreafitis	NN
cord-015021-pol2qm74	8605	43	.	.	.
cord-015021-pol2qm74	8606	1	This	this	DT
cord-015021-pol2qm74	8606	2	injury	injury	NN
cord-015021-pol2qm74	8606	3	was	be	VBD
cord-015021-pol2qm74	8606	4	associated	associate	VBN
cord-015021-pol2qm74	8606	5	w	w	NN
cord-015021-pol2qm74	8606	6	~	~	NFP
cord-015021-pol2qm74	8606	7	th	th	DT
cord-015021-pol2qm74	8606	8	preoperative	preoperative	JJ
cord-015021-pol2qm74	8606	9	renal	renal	JJ
cord-015021-pol2qm74	8606	10	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8606	11	,	,	,
cord-015021-pol2qm74	8606	12	valve	valve	NN
cord-015021-pol2qm74	8606	13	surgery	surgery	NN
cord-015021-pol2qm74	8606	14	,	,	,
cord-015021-pol2qm74	8606	15	~	~	NFP
cord-015021-pol2qm74	8606	16	..	..	NFP
cord-015021-pol2qm74	8606	17	stoperalive	stoperalive	NNP
cord-015021-pol2qm74	8606	18	hytxXension	hytxXension	NNP
cord-015021-pol2qm74	8606	19	,	,	,
cord-015021-pol2qm74	8606	20	calcium	calcium	NN
cord-015021-pol2qm74	8606	21	administered	administer	VBN
cord-015021-pol2qm74	8606	22	periopuratively	periopuratively	RB
cord-015021-pol2qm74	8606	23	and	and	CC
cord-015021-pol2qm74	8606	24	length	length	NN
cord-015021-pol2qm74	8606	25	of	of	IN
cord-015021-pol2qm74	8606	26	bypass	bypass	NN
cord-015021-pol2qm74	8606	27	.	.	.
cord-015021-pol2qm74	8607	1	We	-PRON-	PRP
cord-015021-pol2qm74	8607	2	studied	study	VBD
cord-015021-pol2qm74	8607	3	300	300	CD
cord-015021-pol2qm74	8607	4	patients	patient	NNS
cord-015021-pol2qm74	8607	5	submitted	submit	VBN
cord-015021-pol2qm74	8607	6	to	to	IN
cord-015021-pol2qm74	8607	7	cardiopulmunary	cardiopulmunary	NNP
cord-015021-pol2qm74	8607	8	bypass	bypass	NNP
cord-015021-pol2qm74	8607	9	(	(	-LRB-
cord-015021-pol2qm74	8607	10	CPB	CPB	NNP
cord-015021-pol2qm74	8607	11	)	)	-RRB-
cord-015021-pol2qm74	8607	12	for	for	IN
cord-015021-pol2qm74	8607	13	heart	heart	NN
cord-015021-pol2qm74	8607	14	surgery	surgery	NN
cord-015021-pol2qm74	8607	15	and	and	CC
cord-015021-pol2qm74	8607	16	used	use	VBD
cord-015021-pol2qm74	8607	17	the	the	DT
cord-015021-pol2qm74	8607	18	measurement	measurement	NN
cord-015021-pol2qm74	8607	19	of	of	IN
cord-015021-pol2qm74	8607	20	uN:~sin	uN:~sin	NNP
cord-015021-pol2qm74	8607	21	,	,	,
cord-015021-pol2qm74	8607	22	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8607	23	iso	iso	NN
cord-015021-pol2qm74	8607	24	-	-	HYPH
cord-015021-pol2qm74	8607	25	amylase	amylase	NN
cord-015021-pol2qm74	8607	26	and	and	CC
cord-015021-pol2qm74	8607	27	lipase	lipase	NN
cord-015021-pol2qm74	8607	28	in	in	IN
cord-015021-pol2qm74	8607	29	plasma	plasma	NN
cord-015021-pol2qm74	8607	30	for	for	IN
cord-015021-pol2qm74	8607	31	biochemical	biochemical	JJ
cord-015021-pol2qm74	8607	32	characterization	characterization	NN
cord-015021-pol2qm74	8607	33	of	of	IN
cord-015021-pol2qm74	8607	34	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8607	35	cellular	cellular	JJ
cord-015021-pol2qm74	8607	36	injury	injury	NN
cord-015021-pol2qm74	8607	37	.	.	.
cord-015021-pol2qm74	8608	1	Blood	blood	NN
cord-015021-pol2qm74	8608	2	samples	sample	NNS
cord-015021-pol2qm74	8608	3	were	be	VBD
cord-015021-pol2qm74	8608	4	obtained	obtain	VBN
cord-015021-pol2qm74	8608	5	before	before	IN
cord-015021-pol2qm74	8608	6	surgery	surgery	NN
cord-015021-pol2qm74	8608	7	,	,	,
cord-015021-pol2qm74	8608	8	directly	directly	RB
cord-015021-pol2qm74	8608	9	aller	aller	NNP
cord-015021-pol2qm74	8608	10	surgery	surgery	NN
cord-015021-pol2qm74	8609	1	(	(	-LRB-
cord-015021-pol2qm74	8609	2	return	return	VB
cord-015021-pol2qm74	8609	3	to	to	IN
cord-015021-pol2qm74	8609	4	inte	inte	NNP
cord-015021-pol2qm74	8609	5	~	~	NFP
cord-015021-pol2qm74	8609	6	ve	ve	NNP
cord-015021-pol2qm74	8609	7	care	care	NNP
cord-015021-pol2qm74	8609	8	unit	unit	NN
cord-015021-pol2qm74	8609	9	)	)	-RRB-
cord-015021-pol2qm74	8609	10	,	,	,
cord-015021-pol2qm74	8609	11	8	8	CD
cord-015021-pol2qm74	8609	12	hours	hour	NNS
cord-015021-pol2qm74	8609	13	alter	alter	VBP
cord-015021-pol2qm74	8609	14	surgery	surgery	NN
cord-015021-pol2qm74	8609	15	and	and	CC
cord-015021-pol2qm74	8609	16	in	in	IN
cord-015021-pol2qm74	8609	17	the	the	DT
cord-015021-pol2qm74	8609	18	folfowing	folfowe	VBG
cord-015021-pol2qm74	8609	19	days	day	NNS
cord-015021-pol2qm74	8609	20	alter	alter	VBP
cord-015021-pol2qm74	8609	21	surgery	surgery	NN
cord-015021-pol2qm74	8609	22	(	(	-LRB-
cord-015021-pol2qm74	8609	23	days	day	NNS
cord-015021-pol2qm74	8609	24	1	1	CD
cord-015021-pol2qm74	8609	25	,	,	,
cord-015021-pol2qm74	8609	26	2	2	CD
cord-015021-pol2qm74	8609	27	,	,	,
cord-015021-pol2qm74	8609	28	3	3	CD
cord-015021-pol2qm74	8609	29	,	,	,
cord-015021-pol2qm74	8609	30	4	4	CD
cord-015021-pol2qm74	8609	31	and	and	CC
cord-015021-pol2qm74	8609	32	8)	8)	NN
cord-015021-pol2qm74	8609	33	.	.	.
cord-015021-pol2qm74	8610	1	Computed	compute	VBN
cord-015021-pol2qm74	8610	2	tomography	tomography	NN
cord-015021-pol2qm74	8610	3	scan	scan	NN
cord-015021-pol2qm74	8610	4	of	of	IN
cord-015021-pol2qm74	8610	5	pancreas	pancreas	NN
cord-015021-pol2qm74	8610	6	was	be	VBD
cord-015021-pol2qm74	8610	7	performed	perform	VBN
cord-015021-pol2qm74	8610	8	in	in	IN
cord-015021-pol2qm74	8610	9	patients	patient	NNS
cord-015021-pol2qm74	8610	10	presenting	present	VBG
cord-015021-pol2qm74	8610	11	hi~	hi~	JJ
cord-015021-pol2qm74	8610	12	levels	level	NNS
cord-015021-pol2qm74	8610	13	of	of	IN
cord-015021-pol2qm74	8610	14	amylase	amylase	NN
cord-015021-pol2qm74	8610	15	on	on	IN
cord-015021-pol2qm74	8610	16	day	day	NN
cord-015021-pol2qm74	8610	17	1	1	CD
cord-015021-pol2qm74	8610	18	.	.	.
cord-015021-pol2qm74	8611	1	We	-PRON-	PRP
cord-015021-pol2qm74	8611	2	measured	measure	VBD
cord-015021-pol2qm74	8611	3	abnormal	abnormal	JJ
cord-015021-pol2qm74	8611	4	levels	level	NNS
cord-015021-pol2qm74	8611	5	of	of	IN
cord-015021-pol2qm74	8611	6	trypsin	trypsin	NN
cord-015021-pol2qm74	8611	7	and	and	CC
cord-015021-pol2qm74	8611	8	pancTeatic	pancteatic	JJ
cord-015021-pol2qm74	8611	9	iso	iso	NN
cord-015021-pol2qm74	8611	10	-	-	HYPH
cord-015021-pol2qm74	8611	11	amylase	amylase	NN
cord-015021-pol2qm74	8611	12	in	in	IN
cord-015021-pol2qm74	8611	13	30	30	CD
cord-015021-pol2qm74	8611	14	%	%	NN
cord-015021-pol2qm74	8611	15	of	of	IN
cord-015021-pol2qm74	8611	16	patients	patient	NNS
cord-015021-pol2qm74	8611	17	and	and	CC
cord-015021-pol2qm74	8611	18	observed	observe	VBD
cord-015021-pol2qm74	8611	19	2	2	CD
cord-015021-pol2qm74	8611	20	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	8611	21	releases	release	NNS
cord-015021-pol2qm74	8611	22	of	of	IN
cord-015021-pol2qm74	8611	23	these	these	DT
cord-015021-pol2qm74	8611	24	2	2	CD
cord-015021-pol2qm74	8611	25	enzymes	enzyme	NNS
cord-015021-pol2qm74	8611	26	,	,	,
cord-015021-pol2qm74	8611	27	the	the	DT
cord-015021-pol2qm74	8611	28	fi,'st	fi,'st	NNP
cord-015021-pol2qm74	8611	29	one	one	CD
cord-015021-pol2qm74	8611	30	in	in	IN
cord-015021-pol2qm74	8611	31	the	the	DT
cord-015021-pol2qm74	8611	32	24	24	CD
cord-015021-pol2qm74	8611	33	hours	hour	NNS
cord-015021-pol2qm74	8611	34	after	after	IN
cord-015021-pol2qm74	8611	35	surgery	surgery	NN
cord-015021-pol2qm74	8611	36	and	and	CC
cord-015021-pol2qm74	8611	37	the	the	DT
cord-015021-pol2qm74	8611	38	second	second	JJ
cord-015021-pol2qm74	8611	39	more	more	RBR
cord-015021-pol2qm74	8611	40	intense	intense	JJ
cord-015021-pol2qm74	8611	41	from	from	IN
cord-015021-pol2qm74	8611	42	day	day	NN
cord-015021-pol2qm74	8611	43	4	4	CD
cord-015021-pol2qm74	8611	44	and	and	CC
cord-015021-pol2qm74	8611	45	pa	pa	NNP
cord-015021-pol2qm74	8611	46	~	~	NFP
cord-015021-pol2qm74	8611	47	icularly	icularly	RB
cord-015021-pol2qm74	8611	48	on	on	IN
cord-015021-pol2qm74	8611	49	day	day	NN
cord-015021-pol2qm74	8611	50	8	8	CD
cord-015021-pol2qm74	8611	51	after	after	IN
cord-015021-pol2qm74	8611	52	smgery	smgery	NNP
cord-015021-pol2qm74	8611	53	.	.	.
cord-015021-pol2qm74	8612	1	This	this	DT
cord-015021-pol2qm74	8612	2	second	second	JJ
cord-015021-pol2qm74	8612	3	release	release	NN
cord-015021-pol2qm74	8612	4	was	be	VBD
cord-015021-pol2qm74	8612	5	concomitant	concomitant	JJ
cord-015021-pol2qm74	8612	6	with	with	IN
cord-015021-pol2qm74	8612	7	abnormal	abnormal	JJ
cord-015021-pol2qm74	8612	8	levels	level	NNS
cord-015021-pol2qm74	8612	9	of	of	IN
cord-015021-pol2qm74	8612	10	llpase	llpase	NN
cord-015021-pol2qm74	8612	11	.	.	.
cord-015021-pol2qm74	8613	1	These	these	DT
cord-015021-pol2qm74	8613	2	biochemical	biochemical	JJ
cord-015021-pol2qm74	8613	3	observations	observation	NNS
cord-015021-pol2qm74	8613	4	were	be	VBD
cord-015021-pol2qm74	8613	5	accompanied	accompany	VBN
cord-015021-pol2qm74	8613	6	by	by	IN
cord-015021-pol2qm74	8613	7	radiological	radiological	JJ
cord-015021-pol2qm74	8613	8	and	and	CC
cord-015021-pol2qm74	8613	9	clinical	clinical	JJ
cord-015021-pol2qm74	8613	10	signs	sign	NNS
cord-015021-pol2qm74	8613	11	of	of	IN
cord-015021-pol2qm74	8613	12	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8613	13	injury	injury	NN
cord-015021-pol2qm74	8613	14	in	in	IN
cord-015021-pol2qm74	8613	15	about	about	RB
cord-015021-pol2qm74	8613	16	2	2	CD
cord-015021-pol2qm74	8613	17	%	%	NN
cord-015021-pol2qm74	8613	18	of	of	IN
cord-015021-pol2qm74	8613	19	our	-PRON-	PRP$
cord-015021-pol2qm74	8613	20	patients	patient	NNS
cord-015021-pol2qm74	8613	21	:	:	:
cord-015021-pol2qm74	8613	22	pancrealic	pancrealic	NNP
cord-015021-pol2qm74	8613	23	abnormalities	abnormality	NNS
cord-015021-pol2qm74	8613	24	were	be	VBD
cord-015021-pol2qm74	8613	25	revealed	reveal	VBN
cord-015021-pol2qm74	8613	26	by	by	IN
cord-015021-pol2qm74	8613	27	scan	scan	NN
cord-015021-pol2qm74	8613	28	in	in	IN
cord-015021-pol2qm74	8613	29	7	7	CD
cord-015021-pol2qm74	8613	30	patients	patient	NNS
cord-015021-pol2qm74	8613	31	and	and	CC
cord-015021-pol2qm74	8613	32	acute	acute	JJ
cord-015021-pol2qm74	8613	33	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8613	34	in	in	IN
cord-015021-pol2qm74	8613	35	I	-PRON-	PRP
cord-015021-pol2qm74	8613	36	patient	patient	JJ
cord-015021-pol2qm74	8613	37	.	.	.
cord-015021-pol2qm74	8614	1	More	more	RBR
cord-015021-pol2qm74	8614	2	pronounced	pronounce	VBN
cord-015021-pol2qm74	8614	3	pancreatic	pancreatic	NN
cord-015021-pol2qm74	8614	4	suffering	suffering	NN
cord-015021-pol2qm74	8614	5	was	be	VBD
cord-015021-pol2qm74	8614	6	observed	observe	VBN
cord-015021-pol2qm74	8614	7	in	in	IN
cord-015021-pol2qm74	8614	8	patients	patient	NNS
cord-015021-pol2qm74	8614	9	undergoing	undergo	VBG
cord-015021-pol2qm74	8614	10	valve	valve	NN
cord-015021-pol2qm74	8614	11	replacement	replacement	NN
cord-015021-pol2qm74	8614	12	than	than	IN
cord-015021-pol2qm74	8614	13	in	in	IN
cord-015021-pol2qm74	8614	14	patients	patient	NNS
cord-015021-pol2qm74	8614	15	undergoing	undergo	VBG
cord-015021-pol2qm74	8614	16	coronam	coronam	NN
cord-015021-pol2qm74	8614	17	-	-	HYPH
cord-015021-pol2qm74	8614	18	anrtic	anrtic	JJ
cord-015021-pol2qm74	8614	19	bypass	bypass	NN
cord-015021-pol2qm74	8614	20	grafm~	grafm~	NN
cord-015021-pol2qm74	8615	1	g.	g.	NNP
cord-015021-pol2qm74	8616	1	Analysis	analysis	NN
cord-015021-pol2qm74	8616	2	of	of	IN
cord-015021-pol2qm74	8616	3	trypsin	trypsin	NN
cord-015021-pol2qm74	8616	4	and	and	CC
cord-015021-pol2qm74	8616	5	pare're	pare're	NNP
cord-015021-pol2qm74	8617	1	,	,	,
cord-015021-pol2qm74	8617	2	tic	tic	NNP
cord-015021-pol2qm74	8617	3	1so	1so	NNS
cord-015021-pol2qm74	8617	4	-	-	HYPH
cord-015021-pol2qm74	8617	5	amylase	amylase	NN
cord-015021-pol2qm74	8617	6	are	be	VBP
cord-015021-pol2qm74	8617	7	sw.cific	sw.cific	NNP
cord-015021-pol2qm74	8617	8	of	of	IN
cord-015021-pol2qm74	8617	9	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8617	10	cellular	cellular	JJ
cord-015021-pol2qm74	8617	11	injury	injury	NN
cord-015021-pol2qm74	8617	12	and	and	CC
cord-015021-pol2qm74	8617	13	their	-PRON-	PRP$
cord-015021-pol2qm74	8617	14	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	8617	15	ir	ir	NNP
cord-015021-pol2qm74	8617	16	~	~	NNP
cord-015021-pol2qm74	8617	17	rease	rease	NNP
cord-015021-pol2qm74	8617	18	in	in	IN
cord-015021-pol2qm74	8617	19	plasma	plasma	NN
cord-015021-pol2qm74	8617	20	alter	alter	VB
cord-015021-pol2qm74	8617	21	CPB	CPB	NNP
cord-015021-pol2qm74	8617	22	in	in	IN
cord-015021-pol2qm74	8617	23	our	-PRON-	PRP$
cord-015021-pol2qm74	8617	24	padents	padent	NNS
cord-015021-pol2qm74	8617	25	confirms	confirm	VBZ
cord-015021-pol2qm74	8617	26	the	the	DT
cord-015021-pol2qm74	8617	27	presence	presence	NN
cord-015021-pol2qm74	8617	28	of	of	IN
cord-015021-pol2qm74	8617	29	an	an	DT
cord-015021-pol2qm74	8617	30	exocrine	exocrine	JJ
cord-015021-pol2qm74	8617	31	pancreatic	pancreatic	NN
cord-015021-pol2qm74	8617	32	injury	injury	NN
cord-015021-pol2qm74	8617	33	.	.	.
cord-015021-pol2qm74	8618	1	The	the	DT
cord-015021-pol2qm74	8618	2	presence	presence	NN
cord-015021-pol2qm74	8618	3	of	of	IN
cord-015021-pol2qm74	8618	4	a	a	DT
cord-015021-pol2qm74	8618	5	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	8618	6	peak	peak	NN
cord-015021-pol2qm74	8618	7	of	of	IN
cord-015021-pol2qm74	8618	8	lipase	lipase	NN
cord-015021-pol2qm74	8618	9	mcaezse~	mcaezse~	NNP
cord-015021-pol2qm74	8618	10	the	the	DT
cord-015021-pol2qm74	8618	11	specificity	specificity	NN
cord-015021-pol2qm74	8618	12	of	of	IN
cord-015021-pol2qm74	8618	13	overt	overt	JJ
cord-015021-pol2qm74	8618	14	pancreatic	pancreatic	NN
cord-015021-pol2qm74	8618	15	injtu	injtu	NNP
cord-015021-pol2qm74	8618	16	7	7	CD
cord-015021-pol2qm74	8618	17	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8618	18	.	.	.
cord-015021-pol2qm74	8619	1	The	the	DT
cord-015021-pol2qm74	8619	2	precise	precise	JJ
cord-015021-pol2qm74	8619	3	cause	cause	NN
cord-015021-pol2qm74	8619	4	of	of	IN
cord-015021-pol2qm74	8619	5	th	th	XX
cord-015021-pol2qm74	8619	6	/	/	SYM
cord-015021-pol2qm74	8619	7	s	s	POS
cord-015021-pol2qm74	8619	8	injury	injury	NN
cord-015021-pol2qm74	8619	9	could	could	MD
cord-015021-pol2qm74	8619	10	he	-PRON-	PRP
cord-015021-pol2qm74	8619	11	related	relate	VBN
cord-015021-pol2qm74	8619	12	to	to	IN
cord-015021-pol2qm74	8619	13	hypoperfnsion	hypoperfnsion	NN
cord-015021-pol2qm74	8619	14	leading	lead	VBG
cord-015021-pol2qm74	8619	15	to	to	IN
cord-015021-pol2qm74	8619	16	ischemic	ischemic	JJ
cord-015021-pol2qm74	8619	17	injury	injury	NN
cord-015021-pol2qm74	8619	18	of	of	IN
cord-015021-pol2qm74	8619	19	foe	foe	NNP
cord-015021-pol2qm74	8619	20	splancbnic	splancbnic	NNP
cord-015021-pol2qm74	8619	21	area	area	NN
cord-015021-pol2qm74	8619	22	,	,	,
cord-015021-pol2qm74	8619	23	pancreas	pancrea	NNS
cord-015021-pol2qm74	8619	24	being	be	VBG
cord-015021-pol2qm74	8619	25	largely	largely	RB
cord-015021-pol2qm74	8619	26	sensible	sensible	JJ
cord-015021-pol2qm74	8619	27	to	to	IN
cord-015021-pol2qm74	8619	28	hypoperfnsion	hypoperfnsion	NN
cord-015021-pol2qm74	8619	29	(	(	-LRB-
cord-015021-pol2qm74	8619	30	7	7	CD
cord-015021-pol2qm74	8619	31	)	)	-RRB-
cord-015021-pol2qm74	8619	32	.	.	.
cord-015021-pol2qm74	8620	1	This	this	DT
cord-015021-pol2qm74	8620	2	hypoperfosion	hypoperfosion	NN
cord-015021-pol2qm74	8620	3	could	could	MD
cord-015021-pol2qm74	8620	4	he	-PRON-	PRP
cord-015021-pol2qm74	8620	5	responsible	responsible	JJ
cord-015021-pol2qm74	8620	6	for	for	IN
cord-015021-pol2qm74	8620	7	the	the	DT
cord-015021-pol2qm74	8620	8	ftmt	ftmt	NNP
cord-015021-pol2qm74	8620	9	release	release	NN
cord-015021-pol2qm74	8620	10	of	of	IN
cord-015021-pol2qm74	8620	11	pancrealac	pancrealac	NNP
cord-015021-pol2qm74	8620	12	enzymes	enzyme	NNS
cord-015021-pol2qm74	8620	13	observed	observe	VBN
cord-015021-pol2qm74	8620	14	in	in	IN
cord-015021-pol2qm74	8620	15	our	-PRON-	PRP$
cord-015021-pol2qm74	8620	16	patients	patient	NNS
cord-015021-pol2qm74	8620	17	and	and	CC
cord-015021-pol2qm74	8620	18	would	would	MD
cord-015021-pol2qm74	8620	19	contribute	contribute	VB
cord-015021-pol2qm74	8620	20	to	to	IN
cord-015021-pol2qm74	8620	21	the	the	DT
cord-015021-pol2qm74	8620	22	deterioration	deterioration	NN
cord-015021-pol2qm74	8620	23	of	of	IN
cord-015021-pol2qm74	8620	24	other	other	JJ
cord-015021-pol2qm74	8620	25	organs	organ	NNS
cord-015021-pol2qm74	8620	26	leading	lead	VBG
cord-015021-pol2qm74	8620	27	to	to	IN
cord-015021-pol2qm74	8620	28	an	an	DT
cord-015021-pol2qm74	8620	29	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8620	30	reaction	reaction	NN
cord-015021-pol2qm74	8620	31	developing	develop	VBG
cord-015021-pol2qm74	8620	32	in	in	IN
cord-015021-pol2qm74	8620	33	the	the	DT
cord-015021-pol2qm74	8620	34	following	follow	VBG
cord-015021-pol2qm74	8620	35	days	day	NNS
cord-015021-pol2qm74	8620	36	and	and	CC
cord-015021-pol2qm74	8620	37	responsible	responsible	JJ
cord-015021-pol2qm74	8620	38	for	for	IN
cord-015021-pol2qm74	8620	39	the	the	DT
cord-015021-pol2qm74	8620	40	second	second	JJ
cord-015021-pol2qm74	8620	41	release	release	NN
cord-015021-pol2qm74	8620	42	of	of	IN
cord-015021-pol2qm74	8620	43	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8620	44	enzymes	enzyme	NNS
cord-015021-pol2qm74	8620	45	observed	observe	VBN
cord-015021-pol2qm74	8620	46	in	in	IN
cord-015021-pol2qm74	8620	47	our	-PRON-	PRP$
cord-015021-pol2qm74	8620	48	patients	patient	NNS
cord-015021-pol2qm74	8620	49	.	.	.
cord-015021-pol2qm74	8621	1	Patients	patient	NNS
cord-015021-pol2qm74	8621	2	with	with	IN
cord-015021-pol2qm74	8621	3	necrotizing	necrotize	VBG
cord-015021-pol2qm74	8621	4	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8621	5	show	show	VBP
cord-015021-pol2qm74	8621	6	a	a	DT
cord-015021-pol2qm74	8621	7	heigh	heigh	JJ
cord-015021-pol2qm74	8621	8	rate	rate	NN
cord-015021-pol2qm74	8621	9	of	of	IN
cord-015021-pol2qm74	8621	10	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	8621	11	,	,	,
cord-015021-pol2qm74	8621	12	renal	renal	JJ
cord-015021-pol2qm74	8621	13	and	and	CC
cord-015021-pol2qm74	8621	14	septic	septic	JJ
cord-015021-pol2qm74	8621	15	complications	complication	NNS
cord-015021-pol2qm74	8621	16	,	,	,
cord-015021-pol2qm74	8621	17	whereas	whereas	IN
cord-015021-pol2qm74	8621	18	the	the	DT
cord-015021-pol2qm74	8621	19	course	course	NN
cord-015021-pol2qm74	8621	20	in	in	IN
cord-015021-pol2qm74	8621	21	acute	acute	JJ
cord-015021-pol2qm74	8621	22	interstitial	interstitial	JJ
cord-015021-pol2qm74	8621	23	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8621	24	is	be	VBZ
cord-015021-pol2qm74	8621	25	generally	generally	RB
cord-015021-pol2qm74	8621	26	very	very	RB
cord-015021-pol2qm74	8621	27	mild	mild	JJ
cord-015021-pol2qm74	8621	28	.	.	.
cord-015021-pol2qm74	8622	1	We	-PRON-	PRP
cord-015021-pol2qm74	8622	2	have	have	VBP
cord-015021-pol2qm74	8622	3	prospectively	prospectively	RB
cord-015021-pol2qm74	8622	4	analysed	analyse	VBN
cord-015021-pol2qm74	8622	5	the	the	DT
cord-015021-pol2qm74	8622	6	value	value	NN
cord-015021-pol2qm74	8622	7	of	of	IN
cord-015021-pol2qm74	8622	8	Endotoxin	endotoxin	NN
cord-015021-pol2qm74	8622	9	,	,	,
cord-015021-pol2qm74	8622	10	Interleukin-6(IL-6	interleukin-6(il-6	NN
cord-015021-pol2qm74	8622	11	)	)	-RRB-
cord-015021-pol2qm74	8622	12	and	and	CC
cord-015021-pol2qm74	8622	13	Transferrin	Transferrin	NNP
cord-015021-pol2qm74	8622	14	in	in	IN
cord-015021-pol2qm74	8622	15	compare	compare	NN
cord-015021-pol2qm74	8622	16	with	with	IN
cord-015021-pol2qm74	8622	17	c	c	NN
cord-015021-pol2qm74	8622	18	-	-	HYPH
cord-015021-pol2qm74	8622	19	reactive	reactive	JJ
cord-015021-pol2qm74	8622	20	protein(CRP	protein(CRP	NNP
cord-015021-pol2qm74	8622	21	)	)	-RRB-
cord-015021-pol2qm74	8622	22	for	for	IN
cord-015021-pol2qm74	8622	23	the	the	DT
cord-015021-pol2qm74	8622	24	early	early	JJ
cord-015021-pol2qm74	8622	25	assessment	assessment	NN
cord-015021-pol2qm74	8622	26	of	of	IN
cord-015021-pol2qm74	8622	27	the	the	DT
cord-015021-pol2qm74	8622	28	severity	severity	NN
cord-015021-pol2qm74	8622	29	of	of	IN
cord-015021-pol2qm74	8622	30	acute	acute	JJ
cord-015021-pol2qm74	8622	31	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8622	32	.	.	.
cord-015021-pol2qm74	8623	1	Patients	patient	NNS
cord-015021-pol2qm74	8623	2	aud	aud	NN
cord-015021-pol2qm74	8623	3	methods	method	NNS
cord-015021-pol2qm74	8623	4	:	:	:
cord-015021-pol2qm74	8624	1	The	the	DT
cord-015021-pol2qm74	8624	2	values	value	NNS
cord-015021-pol2qm74	8624	3	of	of	IN
cord-015021-pol2qm74	8624	4	Endotoxin(measured	endotoxin(measure	VBN
cord-015021-pol2qm74	8624	5	by	by	IN
cord-015021-pol2qm74	8624	6	limulus	limulus	NN
cord-015021-pol2qm74	8624	7	-	-	HYPH
cord-015021-pol2qm74	8624	8	lysate	lysate	NN
cord-015021-pol2qm74	8624	9	-	-	HYPH
cord-015021-pol2qm74	8624	10	test	test	NN
cord-015021-pol2qm74	8624	11	)	)	-RRB-
cord-015021-pol2qm74	8624	12	,	,	,
cord-015021-pol2qm74	8624	13	II-6(ELISA	II-6(ELISA	NNP
cord-015021-pol2qm74	8624	14	)	)	-RRB-
cord-015021-pol2qm74	8624	15	,	,	,
cord-015021-pol2qm74	8624	16	transferrin	transferrin	NN
cord-015021-pol2qm74	8624	17	and	and	CC
cord-015021-pol2qm74	8624	18	CRP	CRP	NNP
cord-015021-pol2qm74	8624	19	(	(	-LRB-
cord-015021-pol2qm74	8624	20	nephelometry	nephelometry	NNP
cord-015021-pol2qm74	8624	21	)	)	-RRB-
cord-015021-pol2qm74	8624	22	were	be	VBD
cord-015021-pol2qm74	8624	23	analysed	analyse	VBN
cord-015021-pol2qm74	8624	24	daily	daily	RB
cord-015021-pol2qm74	8624	25	along	along	IN
cord-015021-pol2qm74	8624	26	the	the	DT
cord-015021-pol2qm74	8624	27	first	first	JJ
cord-015021-pol2qm74	8624	28	i0	i0	NN
cord-015021-pol2qm74	8624	29	days	day	NNS
cord-015021-pol2qm74	8624	30	of	of	IN
cord-015021-pol2qm74	8624	31	hospitalisation	hospitalisation	NN
cord-015021-pol2qm74	8624	32	by	by	IN
cord-015021-pol2qm74	8624	33	28	28	CD
cord-015021-pol2qm74	8624	34	patients	patient	NNS
cord-015021-pol2qm74	8624	35	with	with	IN
cord-015021-pol2qm74	8624	36	acute	acute	JJ
cord-015021-pol2qm74	8624	37	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8624	38	admitted	admit	VBN
cord-015021-pol2qm74	8624	39	to	to	IN
cord-015021-pol2qm74	8624	40	our	-PRON-	PRP$
cord-015021-pol2qm74	8624	41	Hospital	Hospital	NNP
cord-015021-pol2qm74	8624	42	from	from	IN
cord-015021-pol2qm74	8624	43	4/1991	4/1991	CD
cord-015021-pol2qm74	8624	44	to	to	IN
cord-015021-pol2qm74	8624	45	4/1993	4/1993	CD
cord-015021-pol2qm74	8624	46	.	.	.
cord-015021-pol2qm74	8625	1	It	-PRON-	PRP
cord-015021-pol2qm74	8625	2	was	be	VBD
cord-015021-pol2qm74	8625	3	judged	judge	VBN
cord-015021-pol2qm74	8625	4	whether	whether	IN
cord-015021-pol2qm74	8625	5	the	the	DT
cord-015021-pol2qm74	8625	6	patients	patient	NNS
cord-015021-pol2qm74	8625	7	have	have	VBP
cord-015021-pol2qm74	8625	8	either	either	DT
cord-015021-pol2qm74	8625	9	interstitial	interstitial	JJ
cord-015021-pol2qm74	8625	10	(	(	-LRB-
cord-015021-pol2qm74	8625	11	AIP	aip	NN
cord-015021-pol2qm74	8625	12	)	)	-RRB-
cord-015021-pol2qm74	8625	13	(	(	-LRB-
cord-015021-pol2qm74	8625	14	n=9	n=9	NN
cord-015021-pol2qm74	8625	15	)	)	-RRB-
cord-015021-pol2qm74	8625	16	or	or	CC
cord-015021-pol2qm74	8625	17	necrotizing	necrotize	VBG
cord-015021-pol2qm74	8625	18	(	(	-LRB-
cord-015021-pol2qm74	8625	19	ANP	ANP	NNP
cord-015021-pol2qm74	8625	20	)	)	-RRB-
cord-015021-pol2qm74	8626	1	(	(	-LRB-
cord-015021-pol2qm74	8626	2	n	n	NN
cord-015021-pol2qm74	8626	3	=	=	SYM
cord-015021-pol2qm74	8626	4	lg	lg	NNP
cord-015021-pol2qm74	8626	5	)	)	-RRB-
cord-015021-pol2qm74	8626	6	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8626	7	.	.	.
cord-015021-pol2qm74	8627	1	5	5	CD
cord-015021-pol2qm74	8627	2	patients	patient	NNS
cord-015021-pol2qm74	8627	3	with	with	IN
cord-015021-pol2qm74	8627	4	ANP	ANP	NNP
cord-015021-pol2qm74	8627	5	have	have	VBP
cord-015021-pol2qm74	8627	6	died	die	VBN
cord-015021-pol2qm74	8627	7	during	during	IN
cord-015021-pol2qm74	8627	8	the	the	DT
cord-015021-pol2qm74	8627	9	course	course	NN
cord-015021-pol2qm74	8627	10	of	of	IN
cord-015021-pol2qm74	8627	11	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8627	12	(	(	-LRB-
cord-015021-pol2qm74	8627	13	Mortality=17.5	Mortality=17.5	NNP
cord-015021-pol2qm74	8627	14	%	%	NN
cord-015021-pol2qm74	8627	15	)	)	-RRB-
cord-015021-pol2qm74	8627	16	.	.	.
cord-015021-pol2qm74	8628	1	Results	result	NNS
cord-015021-pol2qm74	8628	2	:	:	:
cord-015021-pol2qm74	8629	1	1-Severity	1-severity	CD
cord-015021-pol2qm74	8629	2	o~	o~	CD
cord-015021-pol2qm74	8629	3	Pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8629	4	:	:	:
cord-015021-pol2qm74	8630	1	Signifcant	signifcant	JJ
cord-015021-pol2qm74	8630	2	differences	difference	NNS
cord-015021-pol2qm74	8630	3	(	(	-LRB-
cord-015021-pol2qm74	8630	4	P	p	NN
cord-015021-pol2qm74	8630	5	<	<	XX
cord-015021-pol2qm74	8630	6	O.05	o.05	XX
cord-015021-pol2qm74	8630	7	,	,	,
cord-015021-pol2qm74	8630	8	Mann	Mann	NNP
cord-015021-pol2qm74	8630	9	-	-	HYPH
cord-015021-pol2qm74	8630	10	Whitney	Whitney	NNP
cord-015021-pol2qm74	8630	11	test	test	NN
cord-015021-pol2qm74	8630	12	)	)	-RRB-
cord-015021-pol2qm74	8630	13	could	could	MD
cord-015021-pol2qm74	8630	14	be	be	VB
cord-015021-pol2qm74	8630	15	calculated	calculate	VBN
cord-015021-pol2qm74	8630	16	between	between	IN
cord-015021-pol2qm74	8630	17	AIP	AIP	NNP
cord-015021-pol2qm74	8630	18	and	and	CC
cord-015021-pol2qm74	8630	19	ANP	ANP	NNP
cord-015021-pol2qm74	8630	20	for	for	IN
cord-015021-pol2qm74	8630	21	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8630	22	,	,	,
cord-015021-pol2qm74	8630	23	IL-6	IL-6	NNP
cord-015021-pol2qm74	8630	24	,	,	,
cord-015021-pol2qm74	8630	25	transferrin	transferrin	NN
cord-015021-pol2qm74	8630	26	and	and	CC
cord-015021-pol2qm74	8630	27	CRP	crp	NN
cord-015021-pol2qm74	8630	28	during	during	IN
cord-015021-pol2qm74	8630	29	the	the	DT
cord-015021-pol2qm74	8630	30	I0	i0	NN
cord-015021-pol2qm74	8630	31	days	day	NNS
cord-015021-pol2qm74	8630	32	of	of	IN
cord-015021-pol2qm74	8630	33	monitoring	monitoring	NN
cord-015021-pol2qm74	8630	34	.	.	.
cord-015021-pol2qm74	8631	1	2-Mortality	2-mortality	CD
cord-015021-pol2qm74	8631	2	:	:	:
cord-015021-pol2qm74	8632	1	Except	except	IN
cord-015021-pol2qm74	8632	2	of	of	IN
cord-015021-pol2qm74	8632	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	8632	4	on	on	IN
cord-015021-pol2qm74	8632	5	days	day	NNS
cord-015021-pol2qm74	8632	6	2	2	CD
cord-015021-pol2qm74	8632	7	,	,	,
cord-015021-pol2qm74	8632	8	3	3	CD
cord-015021-pol2qm74	8632	9	,	,	,
cord-015021-pol2qm74	8632	10	4	4	CD
cord-015021-pol2qm74	8632	11	and	and	CC
cord-015021-pol2qm74	8632	12	5	5	CD
cord-015021-pol2qm74	8632	13	after	after	IN
cord-015021-pol2qm74	8632	14	ad	ad	NN
cord-015021-pol2qm74	8632	15	-	-	HYPH
cord-015021-pol2qm74	8632	16	mission	mission	NN
cord-015021-pol2qm74	8632	17	there	there	EX
cord-015021-pol2qm74	8632	18	were	be	VBD
cord-015021-pol2qm74	8632	19	no	no	DT
cord-015021-pol2qm74	8632	20	significant	significant	JJ
cord-015021-pol2qm74	8632	21	differences	difference	NNS
cord-015021-pol2qm74	8632	22	between	between	IN
cord-015021-pol2qm74	8632	23	the	the	DT
cord-015021-pol2qm74	8632	24	values	value	NNS
cord-015021-pol2qm74	8632	25	of	of	IN
cord-015021-pol2qm74	8632	26	analysed	analyse	VBN
cord-015021-pol2qm74	8632	27	parameters	parameter	NNS
cord-015021-pol2qm74	8632	28	in	in	IN
cord-015021-pol2qm74	8632	29	patients	patient	NNS
cord-015021-pol2qm74	8632	30	who	who	WP
cord-015021-pol2qm74	8632	31	survived	survive	VBD
cord-015021-pol2qm74	8632	32	and	and	CC
cord-015021-pol2qm74	8632	33	those	those	DT
cord-015021-pol2qm74	8632	34	values	value	NNS
cord-015021-pol2qm74	8632	35	in	in	IN
cord-015021-pol2qm74	8632	36	patients	patient	NNS
cord-015021-pol2qm74	8632	37	who	who	WP
cord-015021-pol2qm74	8632	38	died	die	VBD
cord-015021-pol2qm74	8632	39	.	.	.
cord-015021-pol2qm74	8633	1	3-Organ	3-organ	CD
cord-015021-pol2qm74	8633	2	failure	failure	NN
cord-015021-pol2qm74	8633	3	:	:	:
cord-015021-pol2qm74	8634	1	The	the	DT
cord-015021-pol2qm74	8634	2	patients	patient	NNS
cord-015021-pol2qm74	8634	3	with	with	IN
cord-015021-pol2qm74	8634	4	pulmonary	pulmonary	JJ
cord-015021-pol2qm74	8634	5	,	,	,
cord-015021-pol2qm74	8634	6	renal	renal	JJ
cord-015021-pol2qm74	8634	7	or	or	CC
cord-015021-pol2qm74	8634	8	multiorgan	multiorgan	NN
cord-015021-pol2qm74	8634	9	failure	failure	NN
cord-015021-pol2qm74	8634	10	have	have	VBP
cord-015021-pol2qm74	8634	11	significantly	significantly	RB
cord-015021-pol2qm74	8634	12	heigher	heigh	JJR
cord-015021-pol2qm74	8634	13	values	value	NNS
cord-015021-pol2qm74	8634	14	of	of	IN
cord-015021-pol2qm74	8634	15	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8634	16	,	,	,
cord-015021-pol2qm74	8634	17	IL-6	IL-6	NNP
cord-015021-pol2qm74	8634	18	and	and	CC
cord-015021-pol2qm74	8634	19	CRP	CRP	NNP
cord-015021-pol2qm74	8634	20	along	along	IN
cord-015021-pol2qm74	8634	21	the	the	DT
cord-015021-pol2qm74	8634	22	I0	i0	NN
cord-015021-pol2qm74	8634	23	days	day	NNS
cord-015021-pol2qm74	8634	24	of	of	IN
cord-015021-pol2qm74	8634	25	monitoring	monitoring	NN
cord-015021-pol2qm74	8634	26	in	in	IN
cord-015021-pol2qm74	8634	27	compare	compare	NN
cord-015021-pol2qm74	8634	28	with	with	IN
cord-015021-pol2qm74	8634	29	those	those	DT
cord-015021-pol2qm74	8634	30	patients	patient	NNS
cord-015021-pol2qm74	8634	31	without	without	IN
cord-015021-pol2qm74	8634	32	an	an	DT
cord-015021-pol2qm74	8634	33	organ	organ	NN
cord-015021-pol2qm74	8634	34	failure	failure	NN
cord-015021-pol2qm74	8634	35	.	.	.
cord-015021-pol2qm74	8635	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	8635	2	:	:	:
cord-015021-pol2qm74	8636	1	Endotoxin	Endotoxin	NNP
cord-015021-pol2qm74	8636	2	,	,	,
cord-015021-pol2qm74	8636	3	IL-6	IL-6	NNP
cord-015021-pol2qm74	8636	4	and	and	CC
cord-015021-pol2qm74	8636	5	Transferrin	Transferrin	NNP
cord-015021-pol2qm74	8636	6	,	,	,
cord-015021-pol2qm74	8636	7	an	an	DT
cord-015021-pol2qm74	8636	8	important	important	JJ
cord-015021-pol2qm74	8636	9	endotoxin	endotoxin	NN
cord-015021-pol2qm74	8636	10	carrier	carrier	NN
cord-015021-pol2qm74	8636	11	,	,	,
cord-015021-pol2qm74	8636	12	are	be	VBP
cord-015021-pol2qm74	8636	13	promising	promising	JJ
cord-015021-pol2qm74	8636	14	parameters	parameter	NNS
cord-015021-pol2qm74	8636	15	to	to	TO
cord-015021-pol2qm74	8636	16	differentiate	differentiate	VB
cord-015021-pol2qm74	8636	17	between	between	IN
cord-015021-pol2qm74	8636	18	the	the	DT
cord-015021-pol2qm74	8636	19	severe	severe	JJ
cord-015021-pol2qm74	8636	20	and	and	CC
cord-015021-pol2qm74	8636	21	mild	mild	JJ
cord-015021-pol2qm74	8636	22	form	form	NN
cord-015021-pol2qm74	8636	23	of	of	IN
cord-015021-pol2qm74	8636	24	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8636	25	comparable	comparable	JJ
cord-015021-pol2qm74	8636	26	with	with	IN
cord-015021-pol2qm74	8636	27	CRP	CRP	NNP
cord-015021-pol2qm74	8636	28	.	.	.
cord-015021-pol2qm74	8637	1	This	this	DT
cord-015021-pol2qm74	8637	2	parameters	parameter	NNS
cord-015021-pol2qm74	8637	3	may	may	MD
cord-015021-pol2qm74	8637	4	be	be	VB
cord-015021-pol2qm74	8637	5	helpfull	helpfull	JJ
cord-015021-pol2qm74	8637	6	in	in	IN
cord-015021-pol2qm74	8637	7	the	the	DT
cord-015021-pol2qm74	8637	8	early	early	JJ
cord-015021-pol2qm74	8637	9	clinical	clinical	JJ
cord-015021-pol2qm74	8637	10	assessment	assessment	NN
cord-015021-pol2qm74	8637	11	of	of	IN
cord-015021-pol2qm74	8637	12	patients	patient	NNS
cord-015021-pol2qm74	8637	13	with	with	IN
cord-015021-pol2qm74	8637	14	acute	acute	JJ
cord-015021-pol2qm74	8637	15	panereatitis	panereatitis	NNP
cord-015021-pol2qm74	8637	16	.	.	.
cord-015021-pol2qm74	8638	1	The	the	DT
cord-015021-pol2qm74	8638	2	determination	determination	NN
cord-015021-pol2qm74	8638	3	of	of	IN
cord-015021-pol2qm74	8638	4	cytokines	cytokine	NNS
cord-015021-pol2qm74	8638	5	may	may	MD
cord-015021-pol2qm74	8638	6	elucidate	elucidate	VB
cord-015021-pol2qm74	8638	7	the	the	DT
cord-015021-pol2qm74	8638	8	pathophysiologic	pathophysiologic	NN
cord-015021-pol2qm74	8638	9	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8638	10	that	that	WDT
cord-015021-pol2qm74	8638	11	produce	produce	VBP
cord-015021-pol2qm74	8638	12	early	early	JJ
cord-015021-pol2qm74	8638	13	systemic	systemic	JJ
cord-015021-pol2qm74	8638	14	complications	complication	NNS
cord-015021-pol2qm74	8638	15	in	in	IN
cord-015021-pol2qm74	8638	16	acute	acute	JJ
cord-015021-pol2qm74	8638	17	interstitial	interstitial	NN
cord-015021-pol2qm74	8638	18	(	(	-LRB-
cord-015021-pol2qm74	8638	19	i	i	NN
cord-015021-pol2qm74	8638	20	)	)	-RRB-
cord-015021-pol2qm74	8638	21	or	or	CC
cord-015021-pol2qm74	8638	22	necrotizing	necrotize	VBG
cord-015021-pol2qm74	8638	23	(	(	-LRB-
cord-015021-pol2qm74	8638	24	n	n	LS
cord-015021-pol2qm74	8638	25	)	)	-RRB-
cord-015021-pol2qm74	8638	26	pancreatitis	pancreatitis	NNP
cord-015021-pol2qm74	8638	27	(	(	-LRB-
cord-015021-pol2qm74	8638	28	AP	AP	NNP
cord-015021-pol2qm74	8638	29	)	)	-RRB-
cord-015021-pol2qm74	8638	30	.	.	.
cord-015021-pol2qm74	8639	1	The	the	DT
cord-015021-pol2qm74	8639	2	appearence	appearence	NN
cord-015021-pol2qm74	8639	3	of	of	IN
cord-015021-pol2qm74	8639	4	respiratory	respiratory	JJ
cord-015021-pol2qm74	8639	5	insufficiency	insufficiency	NN
cord-015021-pol2qm74	8639	6	(	(	-LRB-
cord-015021-pol2qm74	8639	7	RI	RI	NNP
cord-015021-pol2qm74	8639	8	)	)	-RRB-
cord-015021-pol2qm74	8639	9	is	be	VBZ
cord-015021-pol2qm74	8639	10	used	use	VBN
cord-015021-pol2qm74	8639	11	to	to	TO
cord-015021-pol2qm74	8639	12	appraise	appraise	VB
cord-015021-pol2qm74	8639	13	the	the	DT
cord-015021-pol2qm74	8639	14	early	early	JJ
cord-015021-pol2qm74	8639	15	systemic	systemic	JJ
cord-015021-pol2qm74	8639	16	complications	complication	NNS
cord-015021-pol2qm74	8639	17	and	and	CC
cord-015021-pol2qm74	8639	18	is	be	VBZ
cord-015021-pol2qm74	8639	19	compared	compare	VBN
cord-015021-pol2qm74	8639	20	to	to	IN
cord-015021-pol2qm74	8639	21	the	the	DT
cord-015021-pol2qm74	8639	22	results	result	NNS
cord-015021-pol2qm74	8639	23	of	of	IN
cord-015021-pol2qm74	8639	24	cytokine	cytokine	JJ
cord-015021-pol2qm74	8639	25	blood	blood	NN
cord-015021-pol2qm74	8639	26	levels	level	NNS
cord-015021-pol2qm74	8639	27	.	.	.
cord-015021-pol2qm74	8640	1	In	in	IN
cord-015021-pol2qm74	8640	2	a	a	DT
cord-015021-pol2qm74	8640	3	prospective	prospective	JJ
cord-015021-pol2qm74	8640	4	clinical	clinical	JJ
cord-015021-pol2qm74	8640	5	trial	trial	NN
cord-015021-pol2qm74	8640	6	from	from	IN
cord-015021-pol2qm74	8640	7	10/92	10/92	CD
cord-015021-pol2qm74	8640	8	-8/93	-8/93	NNS
cord-015021-pol2qm74	8640	9	,	,	,
cord-015021-pol2qm74	8640	10	23	23	CD
cord-015021-pol2qm74	8640	11	patients	patient	NNS
cord-015021-pol2qm74	8640	12	with	with	IN
cord-015021-pol2qm74	8640	13	AP	AP	NNP
cord-015021-pol2qm74	8640	14	were	be	VBD
cord-015021-pol2qm74	8640	15	recruited	recruit	VBN
cord-015021-pol2qm74	8640	16	and	and	CC
cord-015021-pol2qm74	8640	17	blood	blood	NN
cord-015021-pol2qm74	8640	18	samples	sample	NNS
cord-015021-pol2qm74	8640	19	taken	take	VBN
cord-015021-pol2qm74	8640	20	for	for	IN
cord-015021-pol2qm74	8640	21	cytokine	cytokine	JJ
cord-015021-pol2qm74	8640	22	determination	determination	NN
cord-015021-pol2qm74	8640	23	with	with	IN
cord-015021-pol2qm74	8640	24	commercial	commercial	JJ
cord-015021-pol2qm74	8640	25	ELISA	ELISA	NNP
cord-015021-pol2qm74	8640	26	-	-	HYPH
cord-015021-pol2qm74	8640	27	kits	kit	NNS
cord-015021-pol2qm74	8640	28	.	.	.
cord-015021-pol2qm74	8641	1	The	the	DT
cord-015021-pol2qm74	8641	2	differentiation	differentiation	NN
cord-015021-pol2qm74	8641	3	between	between	IN
cord-015021-pol2qm74	8641	4	i	i	PRP
cord-015021-pol2qm74	8641	5	(	(	-LRB-
cord-015021-pol2qm74	8641	6	n=12	n=12	NNP
cord-015021-pol2qm74	8641	7	)	)	-RRB-
cord-015021-pol2qm74	8641	8	and	and	CC
cord-015021-pol2qm74	8641	9	n	n	NNP
cord-015021-pol2qm74	8642	1	(	(	-LRB-
cord-015021-pol2qm74	8642	2	n	n	NN
cord-015021-pol2qm74	8642	3	=	=	SYM
cord-015021-pol2qm74	8642	4	l	l	NN
cord-015021-pol2qm74	8642	5	1	1	CD
cord-015021-pol2qm74	8642	6	)	)	-RRB-
cord-015021-pol2qm74	8642	7	AP	AP	NNP
cord-015021-pol2qm74	8642	8	was	be	VBD
cord-015021-pol2qm74	8642	9	made	make	VBN
cord-015021-pol2qm74	8642	10	through	through	IN
cord-015021-pol2qm74	8642	11	Ct	Ct	NNP
cord-015021-pol2qm74	8642	12	-	-	NN
cord-015021-pol2qm74	8642	13	scan	scan	NN
cord-015021-pol2qm74	8642	14	in	in	IN
cord-015021-pol2qm74	8642	15	all	all	DT
cord-015021-pol2qm74	8642	16	and	and	CC
cord-015021-pol2qm74	8642	17	laparotomy	laparotomy	NN
cord-015021-pol2qm74	8642	18	for	for	IN
cord-015021-pol2qm74	8642	19	drainage	drainage	NN
cord-015021-pol2qm74	8642	20	and	and	CC
cord-015021-pol2qm74	8642	21	necrosectomy	necrosectomy	NN
cord-015021-pol2qm74	8642	22	in	in	IN
cord-015021-pol2qm74	8642	23	13	13	CD
cord-015021-pol2qm74	8642	24	patients	patient	NNS
cord-015021-pol2qm74	8642	25	.	.	.
cord-015021-pol2qm74	8643	1	The	the	DT
cord-015021-pol2qm74	8643	2	etiology	etiology	NN
cord-015021-pol2qm74	8643	3	of	of	IN
cord-015021-pol2qm74	8643	4	AP	AP	NNP
cord-015021-pol2qm74	8643	5	was	be	VBD
cord-015021-pol2qm74	8643	6	gallstones	gallstone	NNS
cord-015021-pol2qm74	8643	7	in	in	IN
cord-015021-pol2qm74	8643	8	9	9	CD
cord-015021-pol2qm74	8643	9	,	,	,
cord-015021-pol2qm74	8643	10	alcohol	alcohol	NN
cord-015021-pol2qm74	8643	11	abuse	abuse	NN
cord-015021-pol2qm74	8643	12	in	in	IN
cord-015021-pol2qm74	8643	13	7	7	CD
cord-015021-pol2qm74	8643	14	,	,	,
cord-015021-pol2qm74	8643	15	hyperlipidemia	hyperlipidemia	NN
cord-015021-pol2qm74	8643	16	in	in	IN
cord-015021-pol2qm74	8643	17	2	2	CD
cord-015021-pol2qm74	8643	18	and	and	CC
cord-015021-pol2qm74	8643	19	other	other	JJ
cord-015021-pol2qm74	8643	20	or	or	CC
cord-015021-pol2qm74	8643	21	unknown	unknown	JJ
cord-015021-pol2qm74	8643	22	causes	cause	NNS
cord-015021-pol2qm74	8643	23	in	in	IN
cord-015021-pol2qm74	8643	24	5	5	CD
cord-015021-pol2qm74	8643	25	patients	patient	NNS
cord-015021-pol2qm74	8643	26	.	.	.
cord-015021-pol2qm74	8644	1	Five	five	CD
cord-015021-pol2qm74	8644	2	of	of	IN
cord-015021-pol2qm74	8644	3	11	11	CD
cord-015021-pol2qm74	8644	4	patients	patient	NNS
cord-015021-pol2qm74	8644	5	with	with	IN
cord-015021-pol2qm74	8644	6	nAP	nap	RB
cord-015021-pol2qm74	8644	7	died	die	VBD
cord-015021-pol2qm74	8644	8	early	early	RB
cord-015021-pol2qm74	8644	9	(	(	-LRB-
cord-015021-pol2qm74	8644	10	n	n	NN
cord-015021-pol2qm74	8644	11	=	=	NN
cord-015021-pol2qm74	8644	12	l	l	NN
cord-015021-pol2qm74	8644	13	)	)	-RRB-
cord-015021-pol2qm74	8644	14	or	or	CC
cord-015021-pol2qm74	8644	15	of	of	IN
cord-015021-pol2qm74	8644	16	late	late	JJ
cord-015021-pol2qm74	8644	17	septic	septic	JJ
cord-015021-pol2qm74	8644	18	complications	complication	NNS
cord-015021-pol2qm74	8644	19	.	.	.
cord-015021-pol2qm74	8645	1	None	none	NN
cord-015021-pol2qm74	8645	2	died	die	VBD
cord-015021-pol2qm74	8645	3	of	of	IN
cord-015021-pol2qm74	8645	4	iAP.The	iAP.The	NNP
cord-015021-pol2qm74	8645	5	peak	peak	NN
cord-015021-pol2qm74	8645	6	of	of	IN
cord-015021-pol2qm74	8645	7	cytnkine	cytnkine	JJ
cord-015021-pol2qm74	8645	8	level	level	NN
cord-015021-pol2qm74	8645	9	in	in	IN
cord-015021-pol2qm74	8645	10	the	the	DT
cord-015021-pol2qm74	8645	11	first	first	JJ
cord-015021-pol2qm74	8645	12	three	three	CD
cord-015021-pol2qm74	8645	13	days	day	NNS
cord-015021-pol2qm74	8645	14	of	of	IN
cord-015021-pol2qm74	8645	15	hospitalisation	hospitalisation	NN
cord-015021-pol2qm74	8645	16	was	be	VBD
cord-015021-pol2qm74	8645	17	used	use	VBN
cord-015021-pol2qm74	8645	18	for	for	IN
cord-015021-pol2qm74	8645	19	calculation	calculation	NN
cord-015021-pol2qm74	8645	20	.	.	.
cord-015021-pol2qm74	8646	1	RI	RI	NNP
cord-015021-pol2qm74	8646	2	was	be	VBD
cord-015021-pol2qm74	8646	3	diagnosed	diagnose	VBN
cord-015021-pol2qm74	8646	4	in	in	IN
cord-015021-pol2qm74	8646	5	the	the	DT
cord-015021-pol2qm74	8646	6	first	first	JJ
cord-015021-pol2qm74	8646	7	week	week	NN
cord-015021-pol2qm74	8646	8	of	of	IN
cord-015021-pol2qm74	8646	9	hospitalisation	hospitalisation	NN
cord-015021-pol2qm74	8646	10	,	,	,
cord-015021-pol2qm74	8646	11	if	if	IN
cord-015021-pol2qm74	8646	12	oxygenmask	oxygenmask	NN
cord-015021-pol2qm74	8646	13	or	or	CC
cord-015021-pol2qm74	8646	14	iutubation	iutubation	NN
cord-015021-pol2qm74	8646	15	for	for	IN
cord-015021-pol2qm74	8646	16	at	at	RB
cord-015021-pol2qm74	8646	17	least	least	JJS
cord-015021-pol2qm74	8646	18	3	3	CD
cord-015021-pol2qm74	8646	19	days	day	NNS
cord-015021-pol2qm74	8646	20	was	be	VBD
cord-015021-pol2qm74	8646	21	nescessary	nescessary	JJ
cord-015021-pol2qm74	8646	22	to	to	TO
cord-015021-pol2qm74	8646	23	treat	treat	VB
cord-015021-pol2qm74	8646	24	arterial	arterial	JJ
cord-015021-pol2qm74	8646	25	hypoxemia	hypoxemia	NN
cord-015021-pol2qm74	8646	26	.	.	.
cord-015021-pol2qm74	8647	1	For	for	IN
cord-015021-pol2qm74	8647	2	statistical	statistical	JJ
cord-015021-pol2qm74	8647	3	analysis	analysis	NN
cord-015021-pol2qm74	8647	4	U	u	NN
cord-015021-pol2qm74	8647	5	-	-	HYPH
cord-015021-pol2qm74	8647	6	Test	Test	NNP
cord-015021-pol2qm74	8647	7	of	of	IN
cord-015021-pol2qm74	8647	8	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	8647	9	,	,	,
cord-015021-pol2qm74	8647	10	Mann	Mann	NNP
cord-015021-pol2qm74	8647	11	and	and	CC
cord-015021-pol2qm74	8647	12	Whitney	Whitney	NNP
cord-015021-pol2qm74	8647	13	was	be	VBD
cord-015021-pol2qm74	8647	14	applicated	applicate	VBN
cord-015021-pol2qm74	8647	15	.	.	.
cord-015021-pol2qm74	8648	1	The	the	DT
cord-015021-pol2qm74	8648	2	IL-6	IL-6	NNP
cord-015021-pol2qm74	8648	3	concentration	concentration	NN
cord-015021-pol2qm74	8648	4	in	in	IN
cord-015021-pol2qm74	8648	5	blood	blood	NN
cord-015021-pol2qm74	8648	6	reached	reach	VBD
cord-015021-pol2qm74	8648	7	up	up	RP
cord-015021-pol2qm74	8648	8	to	to	IN
cord-015021-pol2qm74	8648	9	2600pg	2600pg	CD
cord-015021-pol2qm74	8648	10	/	/	SYM
cord-015021-pol2qm74	8648	11	ml	ml	XX
cord-015021-pol2qm74	8648	12	in	in	IN
cord-015021-pol2qm74	8648	13	the	the	DT
cord-015021-pol2qm74	8648	14	first	first	JJ
cord-015021-pol2qm74	8648	15	days	day	NNS
cord-015021-pol2qm74	8648	16	depending	depend	VBG
cord-015021-pol2qm74	8648	17	on	on	IN
cord-015021-pol2qm74	8648	18	the	the	DT
cord-015021-pol2qm74	8648	19	severity	severity	NN
cord-015021-pol2qm74	8648	20	of	of	IN
cord-015021-pol2qm74	8648	21	AP	AP	NNP
cord-015021-pol2qm74	8648	22	and	and	CC
cord-015021-pol2qm74	8648	23	dropped	drop	VBD
cord-015021-pol2qm74	8648	24	to	to	IN
cord-015021-pol2qm74	8648	25	almost	almost	RB
cord-015021-pol2qm74	8648	26	zero	zero	CD
cord-015021-pol2qm74	8648	27	in	in	IN
cord-015021-pol2qm74	8648	28	the	the	DT
cord-015021-pol2qm74	8648	29	next	next	JJ
cord-015021-pol2qm74	8648	30	days	day	NNS
cord-015021-pol2qm74	8648	31	,	,	,
cord-015021-pol2qm74	8648	32	independently	independently	RB
cord-015021-pol2qm74	8648	33	of	of	IN
cord-015021-pol2qm74	8648	34	the	the	DT
cord-015021-pol2qm74	8648	35	clinical	clinical	JJ
cord-015021-pol2qm74	8648	36	course	course	NN
cord-015021-pol2qm74	8648	37	.	.	.
cord-015021-pol2qm74	8649	1	The	the	DT
cord-015021-pol2qm74	8649	2	differentiation	differentiation	NN
cord-015021-pol2qm74	8649	3	of	of	IN
cord-015021-pol2qm74	8649	4	i	i	NN
cord-015021-pol2qm74	8649	5	-	-	HYPH
cord-015021-pol2qm74	8649	6	versus	versus	IN
cord-015021-pol2qm74	8649	7	nAP	nap	RB
cord-015021-pol2qm74	8649	8	,	,	,
cord-015021-pol2qm74	8649	9	using	use	VBG
cord-015021-pol2qm74	8649	10	a	a	DT
cord-015021-pol2qm74	8649	11	cutoff	cutoff	NN
cord-015021-pol2qm74	8649	12	-	-	HYPH
cord-015021-pol2qm74	8649	13	line	line	NN
cord-015021-pol2qm74	8649	14	of	of	IN
cord-015021-pol2qm74	8649	15	600	600	CD
cord-015021-pol2qm74	8649	16	pg	pg	NN
cord-015021-pol2qm74	8649	17	/	/	SYM
cord-015021-pol2qm74	8649	18	ml	ml	NNS
cord-015021-pol2qm74	8649	19	was	be	VBD
cord-015021-pol2qm74	8649	20	correct	correct	JJ
cord-015021-pol2qm74	8649	21	in	in	IN
cord-015021-pol2qm74	8649	22	20	20	CD
cord-015021-pol2qm74	8649	23	patients	patient	NNS
cord-015021-pol2qm74	8649	24	(	(	-LRB-
cord-015021-pol2qm74	8649	25	87	87	CD
cord-015021-pol2qm74	8649	26	%	%	NN
cord-015021-pol2qm74	8649	27	,	,	,
cord-015021-pol2qm74	8649	28	sensitivity	sensitivity	NN
cord-015021-pol2qm74	8649	29	(	(	-LRB-
cord-015021-pol2qm74	8649	30	SE	SE	NNP
cord-015021-pol2qm74	8649	31	)	)	-RRB-
cord-015021-pol2qm74	8649	32	:	:	:
cord-015021-pol2qm74	8649	33	82%=	82%=	CD
cord-015021-pol2qm74	8649	34	specificity	specificity	NN
cord-015021-pol2qm74	8649	35	(	(	-LRB-
cord-015021-pol2qm74	8649	36	SP	SP	NNP
cord-015021-pol2qm74	8649	37	)	)	-RRB-
cord-015021-pol2qm74	8649	38	:	:	:
cord-015021-pol2qm74	8649	39	91	91	CD
cord-015021-pol2qm74	8649	40	%	%	NN
cord-015021-pol2qm74	8649	41	,	,	,
cord-015021-pol2qm74	8649	42	(	(	-LRB-
cord-015021-pol2qm74	8649	43	z:0,001	z:0,001	NNP
cord-015021-pol2qm74	8649	44	)	)	-RRB-
cord-015021-pol2qm74	8649	45	.	.	.
cord-015021-pol2qm74	8650	1	High	high	JJ
cord-015021-pol2qm74	8650	2	levels	level	NNS
cord-015021-pol2qm74	8650	3	of	of	IN
cord-015021-pol2qm74	8650	4	IL-6	IL-6	NNP
cord-015021-pol2qm74	8650	5	over	over	IN
cord-015021-pol2qm74	8650	6	500	500	CD
cord-015021-pol2qm74	8650	7	pg	pg	NNP
cord-015021-pol2qm74	8650	8	/	/	SYM
cord-015021-pol2qm74	8650	9	ml	ml	NNS
cord-015021-pol2qm74	8650	10	correlated	correlate	VBD
cord-015021-pol2qm74	8650	11	well	well	RB
cord-015021-pol2qm74	8650	12	with	with	IN
cord-015021-pol2qm74	8650	13	the	the	DT
cord-015021-pol2qm74	8650	14	prognosis	prognosis	NN
cord-015021-pol2qm74	8650	15	ifRI	ifRI	NNP
cord-015021-pol2qm74	8650	16	in	in	IN
cord-015021-pol2qm74	8650	17	the	the	DT
cord-015021-pol2qm74	8650	18	first	first	JJ
cord-015021-pol2qm74	8650	19	week	week	NN
cord-015021-pol2qm74	8651	1	(	(	-LRB-
cord-015021-pol2qm74	8651	2	Accuracy	accuracy	NN
cord-015021-pol2qm74	8651	3	:	:	:
cord-015021-pol2qm74	8651	4	87	87	CD
cord-015021-pol2qm74	8651	5	%	%	NN
cord-015021-pol2qm74	8651	6	,	,	,
cord-015021-pol2qm74	8651	7	SE	SE	NNP
cord-015021-pol2qm74	8651	8	:	:	:
cord-015021-pol2qm74	8651	9	80	80	CD
cord-015021-pol2qm74	8651	10	%	%	NN
cord-015021-pol2qm74	8651	11	,	,	,
cord-015021-pol2qm74	8651	12	SP	SP	NNP
cord-015021-pol2qm74	8651	13	:	:	:
cord-015021-pol2qm74	8651	14	100	100	CD
cord-015021-pol2qm74	8651	15	%	%	NN
cord-015021-pol2qm74	8651	16	,	,	,
cord-015021-pol2qm74	8651	17	c~	c~	XX
cord-015021-pol2qm74	8651	18	:	:	:
cord-015021-pol2qm74	8651	19	0,001	0,001	CD
cord-015021-pol2qm74	8651	20	)	)	-RRB-
cord-015021-pol2qm74	8651	21	.	.	.
cord-015021-pol2qm74	8652	1	The	the	DT
cord-015021-pol2qm74	8652	2	blood	blood	NN
cord-015021-pol2qm74	8652	3	levels	level	NNS
cord-015021-pol2qm74	8652	4	of	of	IN
cord-015021-pol2qm74	8652	5	IL-8	IL-8	NNP
cord-015021-pol2qm74	8652	6	reached	reach	VBD
cord-015021-pol2qm74	8652	7	a	a	DT
cord-015021-pol2qm74	8652	8	maximum	maximum	NN
cord-015021-pol2qm74	8652	9	of	of	IN
cord-015021-pol2qm74	8652	10	1381	1381	CD
cord-015021-pol2qm74	8652	11	pg	pg	NN
cord-015021-pol2qm74	8652	12	/	/	SYM
cord-015021-pol2qm74	8652	13	ml	ml	XX
cord-015021-pol2qm74	8652	14	in	in	IN
cord-015021-pol2qm74	8652	15	the	the	DT
cord-015021-pol2qm74	8652	16	first	first	JJ
cord-015021-pol2qm74	8652	17	days	day	NNS
cord-015021-pol2qm74	8652	18	,	,	,
cord-015021-pol2qm74	8652	19	depending	depend	VBG
cord-015021-pol2qm74	8652	20	on	on	IN
cord-015021-pol2qm74	8652	21	the	the	DT
cord-015021-pol2qm74	8652	22	severity	severity	NN
cord-015021-pol2qm74	8652	23	of	of	IN
cord-015021-pol2qm74	8652	24	AP	AP	NNP
cord-015021-pol2qm74	8652	25	,	,	,
cord-015021-pol2qm74	8652	26	and	and	CC
cord-015021-pol2qm74	8652	27	showed	show	VBD
cord-015021-pol2qm74	8652	28	a	a	DT
cord-015021-pol2qm74	8652	29	correlation	correlation	NN
cord-015021-pol2qm74	8652	30	to	to	IN
cord-015021-pol2qm74	8652	31	the	the	DT
cord-015021-pol2qm74	8652	32	clinical	clinical	JJ
cord-015021-pol2qm74	8652	33	course	course	NN
cord-015021-pol2qm74	8652	34	in	in	IN
cord-015021-pol2qm74	8652	35	the	the	DT
cord-015021-pol2qm74	8652	36	following	follow	VBG
cord-015021-pol2qm74	8652	37	days	day	NNS
cord-015021-pol2qm74	8652	38	.	.	.
cord-015021-pol2qm74	8653	1	The	the	DT
cord-015021-pol2qm74	8653	2	peak	peak	NN
cord-015021-pol2qm74	8653	3	of	of	IN
cord-015021-pol2qm74	8653	4	1l,-8	1l,-8	CD
cord-015021-pol2qm74	8653	5	blood	blood	NN
cord-015021-pol2qm74	8653	6	levels	level	NNS
cord-015021-pol2qm74	8653	7	indicated	indicate	VBD
cord-015021-pol2qm74	8653	8	correctly	correctly	RB
cord-015021-pol2qm74	8653	9	the	the	DT
cord-015021-pol2qm74	8653	10	severity	severity	NN
cord-015021-pol2qm74	8653	11	of	of	IN
cord-015021-pol2qm74	8653	12	AP	AP	NNP
cord-015021-pol2qm74	8653	13	in	in	IN
cord-015021-pol2qm74	8653	14	18	18	CD
cord-015021-pol2qm74	8653	15	out	out	IN
cord-015021-pol2qm74	8653	16	of	of	IN
cord-015021-pol2qm74	8653	17	23	23	CD
cord-015021-pol2qm74	8653	18	patients	patient	NNS
cord-015021-pol2qm74	8653	19	using	use	VBG
cord-015021-pol2qm74	8653	20	a	a	DT
cord-015021-pol2qm74	8653	21	cut	cut	NN
cord-015021-pol2qm74	8653	22	offtevel	offtevel	NN
cord-015021-pol2qm74	8653	23	of	of	IN
cord-015021-pol2qm74	8653	24	200	200	CD
cord-015021-pol2qm74	8653	25	pglml	pglml	NNS
cord-015021-pol2qm74	8653	26	(	(	-LRB-
cord-015021-pol2qm74	8653	27	Accuracy	accuracy	NN
cord-015021-pol2qm74	8653	28	:	:	:
cord-015021-pol2qm74	8653	29	78	78	CD
cord-015021-pol2qm74	8653	30	%	%	NN
cord-015021-pol2qm74	8653	31	,	,	,
cord-015021-pol2qm74	8653	32	SE	SE	NNP
cord-015021-pol2qm74	8653	33	:	:	:
cord-015021-pol2qm74	8653	34	82	82	CD
cord-015021-pol2qm74	8653	35	%	%	NN
cord-015021-pol2qm74	8653	36	,	,	,
cord-015021-pol2qm74	8653	37	SP	SP	NNP
cord-015021-pol2qm74	8653	38	:	:	:
cord-015021-pol2qm74	8653	39	75	75	CD
cord-015021-pol2qm74	8653	40	%	%	NN
cord-015021-pol2qm74	8653	41	,	,	,
cord-015021-pol2qm74	8653	42	~	~	CD
cord-015021-pol2qm74	8653	43	:	:	:
cord-015021-pol2qm74	8653	44	0,01	0,01	LS
cord-015021-pol2qm74	8653	45	)	)	-RRB-
cord-015021-pol2qm74	8653	46	.	.	.
cord-015021-pol2qm74	8654	1	There	there	EX
cord-015021-pol2qm74	8654	2	was	be	VBD
cord-015021-pol2qm74	8654	3	no	no	DT
cord-015021-pol2qm74	8654	4	correlation	correlation	NN
cord-015021-pol2qm74	8654	5	between	between	IN
cord-015021-pol2qm74	8654	6	cytokine	cytokine	JJ
cord-015021-pol2qm74	8654	7	blood	blood	NN
cord-015021-pol2qm74	8654	8	levels	level	NNS
cord-015021-pol2qm74	8654	9	and	and	CC
cord-015021-pol2qm74	8654	10	mortality	mortality	NN
cord-015021-pol2qm74	8654	11	,	,	,
cord-015021-pol2qm74	8654	12	Also	also	RB
cord-015021-pol2qm74	8654	13	there	there	EX
cord-015021-pol2qm74	8654	14	seemed	seem	VBD
cord-015021-pol2qm74	8654	15	to	to	TO
cord-015021-pol2qm74	8654	16	be	be	VB
cord-015021-pol2qm74	8654	17	no	no	DT
cord-015021-pol2qm74	8654	18	correlation	correlation	NN
cord-015021-pol2qm74	8654	19	between	between	IN
cord-015021-pol2qm74	8654	20	the	the	DT
cord-015021-pol2qm74	8654	21	levels	level	NNS
cord-015021-pol2qm74	8654	22	of	of	IN
cord-015021-pol2qm74	8654	23	IL-6	IL-6	NNP
cord-015021-pol2qm74	8654	24	and	and	CC
cord-015021-pol2qm74	8654	25	IL-8	IL-8	NNP
cord-015021-pol2qm74	8654	26	.	.	.
cord-015021-pol2qm74	8655	1	In	in	IN
cord-015021-pol2qm74	8655	2	the	the	DT
cord-015021-pol2qm74	8655	3	bloodsamples	bloodsample	NNS
cord-015021-pol2qm74	8655	4	of	of	IN
cord-015021-pol2qm74	8655	5	five	five	CD
cord-015021-pol2qm74	8655	6	patients	patient	NNS
cord-015021-pol2qm74	8655	7	with	with	IN
cord-015021-pol2qm74	8655	8	i	i	PRP
cord-015021-pol2qm74	8655	9	-	-	:
cord-015021-pol2qm74	8655	10	or	or	CC
cord-015021-pol2qm74	8655	11	nAP	nap	XX
cord-015021-pol2qm74	8656	1	no	no	UH
cord-015021-pol2qm74	8657	1	c~-TNF	c~-TNF	NNP
cord-015021-pol2qm74	8657	2	was	be	VBD
cord-015021-pol2qm74	8657	3	detectable	detectable	JJ
cord-015021-pol2qm74	8657	4	.	.	.
cord-015021-pol2qm74	8658	1	The	the	DT
cord-015021-pol2qm74	8658	2	blood	blood	NN
cord-015021-pol2qm74	8658	3	levels	level	NNS
cord-015021-pol2qm74	8658	4	of	of	IN
cord-015021-pol2qm74	8658	5	IL-6	IL-6	NNP
cord-015021-pol2qm74	8658	6	,	,	,
cord-015021-pol2qm74	8658	7	and	and	CC
cord-015021-pol2qm74	8658	8	to	to	IN
cord-015021-pol2qm74	8658	9	a	a	DT
cord-015021-pol2qm74	8658	10	lesser	less	JJR
cord-015021-pol2qm74	8658	11	extent	extent	NN
cord-015021-pol2qm74	8658	12	of	of	IN
cord-015021-pol2qm74	8658	13	[	[	-LRB-
cord-015021-pol2qm74	8658	14	L-8	L-8	NNP
cord-015021-pol2qm74	8658	15	,	,	,
cord-015021-pol2qm74	8658	16	can	can	MD
cord-015021-pol2qm74	8658	17	predict	predict	VB
cord-015021-pol2qm74	8658	18	the	the	DT
cord-015021-pol2qm74	8658	19	severity	severity	NN
cord-015021-pol2qm74	8658	20	and	and	CC
cord-015021-pol2qm74	8658	21	early	early	JJ
cord-015021-pol2qm74	8658	22	systemic	systemic	JJ
cord-015021-pol2qm74	8658	23	complications	complication	NNS
cord-015021-pol2qm74	8658	24	of	of	IN
cord-015021-pol2qm74	8658	25	AP	AP	NNP
cord-015021-pol2qm74	8658	26	in	in	IN
cord-015021-pol2qm74	8658	27	men	man	NNS
cord-015021-pol2qm74	8658	28	.	.	.
cord-015021-pol2qm74	8659	1	The	the	DT
cord-015021-pol2qm74	8659	2	excessive	excessive	JJ
cord-015021-pol2qm74	8659	3	rise	rise	NN
cord-015021-pol2qm74	8659	4	of	of	IN
cord-015021-pol2qm74	8659	5	cytokines	cytokine	NNS
cord-015021-pol2qm74	8659	6	can	can	MD
cord-015021-pol2qm74	8659	7	be	be	VB
cord-015021-pol2qm74	8659	8	explained	explain	VBN
cord-015021-pol2qm74	8659	9	by	by	IN
cord-015021-pol2qm74	8659	10	the	the	DT
cord-015021-pol2qm74	8659	11	stimulation	stimulation	NN
cord-015021-pol2qm74	8659	12	of	of	IN
cord-015021-pol2qm74	8659	13	immunological	immunological	JJ
cord-015021-pol2qm74	8659	14	cells	cell	NNS
cord-015021-pol2qm74	8659	15	(	(	-LRB-
cord-015021-pol2qm74	8659	16	macrophages	macrophage	NNS
cord-015021-pol2qm74	8659	17	,	,	,
cord-015021-pol2qm74	8659	18	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8659	19	and	and	CC
cord-015021-pol2qm74	8659	20	endothelial	endothelial	JJ
cord-015021-pol2qm74	8659	21	cells	cell	NNS
cord-015021-pol2qm74	8659	22	)	)	-RRB-
cord-015021-pol2qm74	8659	23	in	in	IN
cord-015021-pol2qm74	8659	24	the	the	DT
cord-015021-pol2qm74	8659	25	course	course	NN
cord-015021-pol2qm74	8659	26	of	of	IN
cord-015021-pol2qm74	8659	27	AP	AP	NNP
cord-015021-pol2qm74	8659	28	.	.	.
cord-015021-pol2qm74	8660	1	Objectives	objective	NNS
cord-015021-pol2qm74	8660	2	:	:	:
cord-015021-pol2qm74	8660	3	In	in	IN
cord-015021-pol2qm74	8660	4	an	an	DT
cord-015021-pol2qm74	8660	5	opossum	opossum	NN
cord-015021-pol2qm74	8660	6	model	model	NN
cord-015021-pol2qm74	8660	7	,	,	,
cord-015021-pol2qm74	8660	8	ligation	ligation	NN
cord-015021-pol2qm74	8660	9	of	of	IN
cord-015021-pol2qm74	8660	10	the	the	DT
cord-015021-pol2qm74	8660	11	sphincter	sphincter	NN
cord-015021-pol2qm74	8660	12	of	of	IN
cord-015021-pol2qm74	8660	13	Oddi	Oddi	NNP
cord-015021-pol2qm74	8660	14	or	or	CC
cord-015021-pol2qm74	8660	15	separate	separate	JJ
cord-015021-pol2qm74	8660	16	ligation	ligation	NN
cord-015021-pol2qm74	8660	17	of	of	IN
cord-015021-pol2qm74	8660	18	the	the	DT
cord-015021-pol2qm74	8660	19	bile	bile	NN
cord-015021-pol2qm74	8660	20	and	and	CC
cord-015021-pol2qm74	8660	21	the	the	DT
cord-015021-pol2qm74	8660	22	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8660	23	duct	duct	NN
cord-015021-pol2qm74	8660	24	together	together	RB
cord-015021-pol2qm74	8660	25	leads	lead	VBZ
cord-015021-pol2qm74	8660	26	to	to	IN
cord-015021-pol2qm74	8660	27	severe	severe	JJ
cord-015021-pol2qm74	8660	28	haemorrhagic	haemorrhagic	JJ
cord-015021-pol2qm74	8660	29	pancreatffis	pancreatffis	NN
cord-015021-pol2qm74	8660	30	while	while	IN
cord-015021-pol2qm74	8660	31	single	single	JJ
cord-015021-pol2qm74	8660	32	ligation	ligation	NN
cord-015021-pol2qm74	8660	33	of	of	IN
cord-015021-pol2qm74	8660	34	the	the	DT
cord-015021-pol2qm74	8660	35	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8660	36	duct	duct	NN
cord-015021-pol2qm74	8660	37	causes	cause	VBZ
cord-015021-pol2qm74	8660	38	only	only	RB
cord-015021-pol2qm74	8660	39	an	an	DT
cord-015021-pol2qm74	8660	40	exocdne	exocdne	NN
cord-015021-pol2qm74	8660	41	atrophy	atrophy	NN
cord-015021-pol2qm74	8660	42	.	.	.
cord-015021-pol2qm74	8661	1	Since	since	IN
cord-015021-pol2qm74	8661	2	BO	BO	NNP
cord-015021-pol2qm74	8661	3	has	have	VBZ
cord-015021-pol2qm74	8661	4	been	be	VBN
cord-015021-pol2qm74	8661	5	discussed	discuss	VBN
cord-015021-pol2qm74	8661	6	to	to	TO
cord-015021-pol2qm74	8661	7	be	be	VB
cord-015021-pol2qm74	8661	8	a	a	DT
cord-015021-pol2qm74	8661	9	contdbutor	contdbutor	NN
cord-015021-pol2qm74	8661	10	t¢	t¢	NN
cord-015021-pol2qm74	8661	11	,	,	,
cord-015021-pol2qm74	8661	12	RES	res	NN
cord-015021-pol2qm74	8661	13	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8661	14	,	,	,
cord-015021-pol2qm74	8661	15	this	this	DT
cord-015021-pol2qm74	8661	16	may	may	MD
cord-015021-pol2qm74	8661	17	depdve	depdve	VB
cord-015021-pol2qm74	8661	18	the	the	DT
cord-015021-pol2qm74	8661	19	organism	organism	NN
cord-015021-pol2qm74	8661	20	of	of	IN
cord-015021-pol2qm74	8661	21	a	a	DT
cord-015021-pol2qm74	8661	22	potent	potent	JJ
cord-015021-pol2qm74	8661	23	defensive	defensive	JJ
cord-015021-pol2qm74	8661	24	mechanism	mechanism	NN
cord-015021-pol2qm74	8661	25	thus	thus	RB
cord-015021-pol2qm74	8661	26	promoting	promote	VBG
cord-015021-pol2qm74	8661	27	the	the	DT
cord-015021-pol2qm74	8661	28	course	course	NN
cord-015021-pol2qm74	8661	29	of	of	IN
cord-015021-pol2qm74	8661	30	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8661	31	.	.	.
cord-015021-pol2qm74	8662	1	The	the	DT
cord-015021-pol2qm74	8662	2	present	present	JJ
cord-015021-pol2qm74	8662	3	study	study	NN
cord-015021-pol2qm74	8662	4	wa	wa	NNP
cord-015021-pol2qm74	8662	5	,	,	,
cord-015021-pol2qm74	8662	6	,	,	,
cord-015021-pol2qm74	8662	7	;	;	:
cord-015021-pol2qm74	8662	8	carded	card	VBD
cord-015021-pol2qm74	8662	9	out	out	RP
cord-015021-pol2qm74	8662	10	tc	tc	NNP
cord-015021-pol2qm74	8662	11	develop	develop	VB
cord-015021-pol2qm74	8662	12	a	a	DT
cord-015021-pol2qm74	8662	13	new	new	JJ
cord-015021-pol2qm74	8662	14	method	method	NN
cord-015021-pol2qm74	8662	15	for	for	IN
cord-015021-pol2qm74	8662	16	measuring	measure	VBG
cord-015021-pol2qm74	8662	17	dynamic	dynamic	JJ
cord-015021-pol2qm74	8662	18	liver	liver	NN
cord-015021-pol2qm74	8662	19	RES	res	NN
cord-015021-pol2qm74	8662	20	func	func	NN
cord-015021-pol2qm74	8662	21	..	..	NFP
cord-015021-pol2qm74	8662	22	tion	tion	NN
cord-015021-pol2qm74	8662	23	and	and	CC
cord-015021-pol2qm74	8662	24	to	to	TO
cord-015021-pol2qm74	8662	25	test	test	VB
cord-015021-pol2qm74	8662	26	the	the	DT
cord-015021-pol2qm74	8662	27	hypothesis	hypothesis	NN
cord-015021-pol2qm74	8662	28	that	that	WDT
cord-015021-pol2qm74	8662	29	BO	BO	NNP
cord-015021-pol2qm74	8662	30	causes	cause	VBZ
cord-015021-pol2qm74	8662	31	a	a	DT
cord-015021-pol2qm74	8662	32	RES	res	NN
cord-015021-pol2qm74	8662	33	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8662	34	.	.	.
cord-015021-pol2qm74	8663	1	Material	Material	NNP
cord-015021-pol2qm74	8663	2	&	&	CC
cord-015021-pol2qm74	8663	3	Methods	Methods	NNPS
cord-015021-pol2qm74	8663	4	:	:	:
cord-015021-pol2qm74	8663	5	18	18	CD
cord-015021-pol2qm74	8663	6	opossums	opossum	NNS
cord-015021-pol2qm74	8663	7	were	be	VBD
cord-015021-pol2qm74	8663	8	randomly	randomly	RB
cord-015021-pol2qm74	8663	9	placed	place	VBN
cord-015021-pol2qm74	8663	10	in	in	IN
cord-015021-pol2qm74	8663	11	three	three	CD
cord-015021-pol2qm74	8663	12	groups	group	NNS
cord-015021-pol2qm74	8663	13	.	.	.
cord-015021-pol2qm74	8664	1	All	all	DT
cord-015021-pol2qm74	8664	2	received	receive	VBD
cord-015021-pol2qm74	8664	3	a	a	DT
cord-015021-pol2qm74	8664	4	central	central	JJ
cord-015021-pol2qm74	8664	5	venous	venous	JJ
cord-015021-pol2qm74	8664	6	line	line	NN
cord-015021-pol2qm74	8664	7	.	.	.
cord-015021-pol2qm74	8665	1	After	after	IN
cord-015021-pol2qm74	8665	2	midline	midline	JJ
cord-015021-pol2qm74	8665	3	laparotomy	laparotomy	NN
cord-015021-pol2qm74	8665	4	,	,	,
cord-015021-pol2qm74	8665	5	a	a	DT
cord-015021-pol2qm74	8665	6	specially	specially	RB
cord-015021-pol2qm74	8665	7	designe0	designe0	NN
cord-015021-pol2qm74	8665	8	tourniquet	tourniquet	NN
cord-015021-pol2qm74	8665	9	was	be	VBD
cord-015021-pol2qm74	8665	10	placed	place	VBN
cord-015021-pol2qm74	8665	11	around	around	IN
cord-015021-pol2qm74	8665	12	the	the	DT
cord-015021-pol2qm74	8665	13	common	common	JJ
cord-015021-pol2qm74	8665	14	hepatic	hepatic	JJ
cord-015021-pol2qm74	8665	15	duct	duct	NN
cord-015021-pol2qm74	8665	16	above	above	IN
cord-015021-pol2qm74	8665	17	its	-PRON-	PRP$
cord-015021-pol2qm74	8665	18	junction	junction	NN
cord-015021-pol2qm74	8665	19	with	with	IN
cord-015021-pol2qm74	8665	20	the	the	DT
cord-015021-pol2qm74	8665	21	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8665	22	duct	duct	NN
cord-015021-pol2qm74	8665	23	(	(	-LRB-
cord-015021-pol2qm74	8665	24	group	group	NN
cord-015021-pol2qm74	8665	25	A	A	NNP
cord-015021-pol2qm74	8665	26	,	,	,
cord-015021-pol2qm74	8665	27	n=6	n=6	JJ
cord-015021-pol2qm74	8665	28	)	)	-RRB-
cord-015021-pol2qm74	8665	29	,	,	,
cord-015021-pol2qm74	8665	30	around	around	IN
cord-015021-pol2qm74	8665	31	the	the	DT
cord-015021-pol2qm74	8665	32	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8665	33	duct	duct	NN
cord-015021-pol2qm74	8665	34	(	(	-LRB-
cord-015021-pol2qm74	8665	35	group	group	NN
cord-015021-pol2qm74	8665	36	B	B	NNP
cord-015021-pol2qm74	8665	37	,	,	,
cord-015021-pol2qm74	8665	38	n=6	n=6	JJ
cord-015021-pol2qm74	8665	39	)	)	-RRB-
cord-015021-pol2qm74	8665	40	or	or	CC
cord-015021-pol2qm74	8665	41	around	around	IN
cord-015021-pol2qm74	8665	42	both	both	DT
cord-015021-pol2qm74	8665	43	ducts	duct	NNS
cord-015021-pol2qm74	8665	44	(	(	-LRB-
cord-015021-pol2qm74	8665	45	group	group	NN
cord-015021-pol2qm74	8665	46	C	C	NNP
cord-015021-pol2qm74	8665	47	,	,	,
cord-015021-pol2qm74	8665	48	n=6	n=6	NN
cord-015021-pol2qm74	8665	49	)	)	-RRB-
cord-015021-pol2qm74	8665	50	.	.	.
cord-015021-pol2qm74	8666	1	After	after	IN
cord-015021-pol2qm74	8666	2	one	one	CD
cord-015021-pol2qm74	8666	3	week	week	NN
cord-015021-pol2qm74	8666	4	,	,	,
cord-015021-pol2qm74	8666	5	the	the	DT
cord-015021-pol2qm74	8666	6	tourniquets	tourniquet	NNS
cord-015021-pol2qm74	8666	7	were	be	VBD
cord-015021-pol2qm74	8666	8	closed	close	VBN
cord-015021-pol2qm74	8666	9	.	.	.
cord-015021-pol2qm74	8667	1	Using	use	VBG
cord-015021-pol2qm74	8667	2	a	a	DT
cord-015021-pol2qm74	8667	3	scintillation	scintillation	NN
cord-015021-pol2qm74	8667	4	camera	camera	NN
cord-015021-pol2qm74	8667	5	,	,	,
cord-015021-pol2qm74	8667	6	the	the	DT
cord-015021-pol2qm74	8667	7	liver	liver	NN
cord-015021-pol2qm74	8667	8	uptake	uptake	NN
cord-015021-pol2qm74	8667	9	of	of	IN
cord-015021-pol2qm74	8667	10	Nanocoll	Nanocoll	NNP
cord-015021-pol2qm74	8667	11	,	,	,
cord-015021-pol2qm74	8667	12	a	a	DT
cord-015021-pol2qm74	8667	13	99mTcalbumin	99mtcalbumin	CD
cord-015021-pol2qm74	8667	14	colloid	colloid	NN
cord-015021-pol2qm74	8667	15	with	with	IN
cord-015021-pol2qm74	8667	16	a	a	DT
cord-015021-pol2qm74	8667	17	diameter	diameter	NN
cord-015021-pol2qm74	8667	18	of	of	IN
cord-015021-pol2qm74	8667	19	25	25	CD
cord-015021-pol2qm74	8667	20	nm	nm	NN
cord-015021-pol2qm74	8667	21	,	,	,
cord-015021-pol2qm74	8667	22	was	be	VBD
cord-015021-pol2qm74	8667	23	measured	measure	VBN
cord-015021-pol2qm74	8667	24	before	before	RB
cord-015021-pol2qm74	8667	25	,	,	,
cord-015021-pol2qm74	8667	26	2,5	2,5	CD
cord-015021-pol2qm74	8667	27	and	and	CC
cord-015021-pol2qm74	8667	28	6	6	CD
cord-015021-pol2qm74	8667	29	days	day	NNS
cord-015021-pol2qm74	8667	30	after	after	IN
cord-015021-pol2qm74	8667	31	the	the	DT
cord-015021-pol2qm74	8667	32	obstruction	obstruction	NN
cord-015021-pol2qm74	8667	33	.	.	.
cord-015021-pol2qm74	8668	1	The	the	DT
cord-015021-pol2qm74	8668	2	curves	curve	NNS
cord-015021-pol2qm74	8668	3	were	be	VBD
cord-015021-pol2qm74	8668	4	analysed	analyse	VBN
cord-015021-pol2qm74	8668	5	by	by	IN
cord-015021-pol2qm74	8668	6	a	a	DT
cord-015021-pol2qm74	8668	7	computer	computer	NN
cord-015021-pol2qm74	8668	8	and	and	CC
cord-015021-pol2qm74	8668	9	two	two	CD
cord-015021-pol2qm74	8668	10	parameters	parameter	NNS
cord-015021-pol2qm74	8668	11	(	(	-LRB-
cord-015021-pol2qm74	8668	12	R	r	NN
cord-015021-pol2qm74	8668	13	,	,	,
cord-015021-pol2qm74	8668	14	S	S	NNP
cord-015021-pol2qm74	8668	15	)	)	-RRB-
cord-015021-pol2qm74	8668	16	were	be	VBD
cord-015021-pol2qm74	8668	17	calculated	calculate	VBN
cord-015021-pol2qm74	8668	18	using	use	VBG
cord-015021-pol2qm74	8668	19	natural	natural	JJ
cord-015021-pol2qm74	8668	20	logarithmic	logarithmic	JJ
cord-015021-pol2qm74	8668	21	regression	regression	NN
cord-015021-pol2qm74	8668	22	.	.	.
cord-015021-pol2qm74	8669	1	As	as	IN
cord-015021-pol2qm74	8669	2	a	a	DT
cord-015021-pol2qm74	8669	3	common	common	JJ
cord-015021-pol2qm74	8669	4	measure	measure	NN
cord-015021-pol2qm74	8669	5	for	for	IN
cord-015021-pol2qm74	8669	6	RES	res	NN
cord-015021-pol2qm74	8669	7	function	function	NN
cord-015021-pol2qm74	8669	8	,	,	,
cord-015021-pol2qm74	8669	9	the	the	DT
cord-015021-pol2qm74	8669	10	corrected	correct	VBN
cord-015021-pol2qm74	8669	11	granulopexic	granulopexic	NNP
cord-015021-pol2qm74	8669	12	index	index	NN
cord-015021-pol2qm74	8669	13	(	(	-LRB-
cord-015021-pol2qm74	8669	14	a	a	LS
cord-015021-pol2qm74	8669	15	)	)	-RRB-
cord-015021-pol2qm74	8669	16	wa	wa	NNP
cord-015021-pol2qm74	8669	17	,	,	,
cord-015021-pol2qm74	8669	18	,	,	,
cord-015021-pol2qm74	8669	19	;	;	,
cord-015021-pol2qm74	8669	20	determined	determine	VBN
cord-015021-pol2qm74	8669	21	,	,	,
cord-015021-pol2qm74	8669	22	After	after	IN
cord-015021-pol2qm74	8669	23	day	day	NN
cord-015021-pol2qm74	8669	24	6	6	CD
cord-015021-pol2qm74	8669	25	,	,	,
cord-015021-pol2qm74	8669	26	the	the	DT
cord-015021-pol2qm74	8669	27	pancreas	pancreas	NN
cord-015021-pol2qm74	8669	28	of	of	IN
cord-015021-pol2qm74	8669	29	each	each	DT
cord-015021-pol2qm74	8669	30	opossum	opossum	NN
cord-015021-pol2qm74	8669	31	was	be	VBD
cord-015021-pol2qm74	8669	32	searched	search	VBN
cord-015021-pol2qm74	8669	33	for	for	IN
cord-015021-pol2qm74	8669	34	necrosis	necrosis	NN
cord-015021-pol2qm74	8669	35	by	by	IN
cord-015021-pol2qm74	8669	36	morphometdc	morphometdc	NN
cord-015021-pol2qm74	8669	37	methods	method	NNS
cord-015021-pol2qm74	8669	38	.	.	.
cord-015021-pol2qm74	8670	1	Results	result	NNS
cord-015021-pol2qm74	8670	2	:	:	:
cord-015021-pol2qm74	8671	1	All	all	DT
cord-015021-pol2qm74	8671	2	animals	animal	NNS
cord-015021-pol2qm74	8671	3	survived	survive	VBD
cord-015021-pol2qm74	8671	4	till	till	IN
cord-015021-pol2qm74	8671	5	day	day	NN
cord-015021-pol2qm74	8671	6	6	6	CD
cord-015021-pol2qm74	8671	7	.	.	.
cord-015021-pol2qm74	8672	1	The	the	DT
cord-015021-pol2qm74	8672	2	opossums	opossum	NNS
cord-015021-pol2qm74	8672	3	in	in	IN
cord-015021-pol2qm74	8672	4	groups	group	NNS
cord-015021-pol2qm74	8672	5	A	A	NNP
cord-015021-pol2qm74	8672	6	&	&	CC
cord-015021-pol2qm74	8672	7	8	8	CD
cord-015021-pol2qm74	8672	8	had	have	VBD
cord-015021-pol2qm74	8672	9	a	a	DT
cord-015021-pol2qm74	8672	10	macro	macro	NN
cord-015021-pol2qm74	8672	11	-	-	HYPH
cord-015021-pol2qm74	8672	12	and	and	CC
cord-015021-pol2qm74	8672	13	microscopic	microscopic	JJ
cord-015021-pol2qm74	8672	14	normal	normal	JJ
cord-015021-pol2qm74	8672	15	pancreas	pancrea	NNS
cord-015021-pol2qm74	8672	16	,	,	,
cord-015021-pol2qm74	8672	17	while	while	IN
cord-015021-pol2qm74	8672	18	those	those	DT
cord-015021-pol2qm74	8672	19	in	in	IN
cord-015021-pol2qm74	8672	20	group	group	NN
cord-015021-pol2qm74	8672	21	C	C	NNP
cord-015021-pol2qm74	8672	22	showed	show	VBD
cord-015021-pol2qm74	8672	23	a	a	DT
cord-015021-pol2qm74	8672	24	severe	severe	JJ
cord-015021-pol2qm74	8672	25	hemorrhagic	hemorrhagic	JJ
cord-015021-pol2qm74	8672	26	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8672	27	.	.	.
cord-015021-pol2qm74	8673	1	The	the	DT
cord-015021-pol2qm74	8673	2	granuinpexic	granuinpexic	NNP
cord-015021-pol2qm74	8673	3	index	index	NN
cord-015021-pol2qm74	8673	4	showed	show	VBD
cord-015021-pol2qm74	8673	5	a	a	DT
cord-015021-pol2qm74	8673	6	significan~	significan~	NNP
cord-015021-pol2qm74	8673	7	change	change	NN
cord-015021-pol2qm74	8673	8	to	to	IN
cord-015021-pol2qm74	8673	9	the	the	DT
cord-015021-pol2qm74	8673	10	worse	bad	JJR
cord-015021-pol2qm74	8673	11	starting	start	VBG
cord-015021-pol2qm74	8673	12	at	at	IN
cord-015021-pol2qm74	8673	13	day	day	NN
cord-015021-pol2qm74	8673	14	5	5	CD
cord-015021-pol2qm74	8673	15	in	in	IN
cord-015021-pol2qm74	8673	16	group	group	NN
cord-015021-pol2qm74	8673	17	A	A	NNP
cord-015021-pol2qm74	8673	18	&	&	CC
cord-015021-pol2qm74	8673	19	B	b	NN
cord-015021-pol2qm74	8674	1	(	(	-LRB-
cord-015021-pol2qm74	8674	2	p	p	NN
cord-015021-pol2qm74	8674	3	<	<	XX
cord-015021-pol2qm74	8674	4	O,05	o,05	NN
cord-015021-pol2qm74	8674	5	)	)	-RRB-
cord-015021-pol2qm74	8675	1	and	and	CC
cord-015021-pol2qm74	8675	2	at	at	IN
cord-015021-pol2qm74	8675	3	day	day	NN
cord-015021-pol2qm74	8675	4	2	2	CD
cord-015021-pol2qm74	8675	5	it~	it~	NNP
cord-015021-pol2qm74	8675	6	group	group	NN
cord-015021-pol2qm74	8675	7	C	C	NNP
cord-015021-pol2qm74	8675	8	(	(	-LRB-
cord-015021-pol2qm74	8675	9	p<0,Ol	p<0,ol	NN
cord-015021-pol2qm74	8675	10	)	)	-RRB-
cord-015021-pol2qm74	8675	11	.	.	.
cord-015021-pol2qm74	8676	1	At	at	IN
cord-015021-pol2qm74	8676	2	day	day	NN
cord-015021-pol2qm74	8676	3	6	6	CD
cord-015021-pol2qm74	8676	4	,	,	,
cord-015021-pol2qm74	8676	5	RES	res	NN
cord-015021-pol2qm74	8676	6	function	function	NN
cord-015021-pol2qm74	8676	7	in	in	IN
cord-015021-pol2qm74	8676	8	group	group	NN
cord-015021-pol2qm74	8676	9	C	C	NNP
cord-015021-pol2qm74	8676	10	was	be	VBD
cord-015021-pol2qm74	8676	11	significantly	significantly	RB
cord-015021-pol2qm74	8676	12	worse	bad	JJR
cord-015021-pol2qm74	8676	13	than	than	IN
cord-015021-pol2qm74	8676	14	that	that	DT
cord-015021-pol2qm74	8676	15	in	in	IN
cord-015021-pol2qm74	8676	16	group	group	NN
cord-015021-pol2qm74	8676	17	A	A	NNP
cord-015021-pol2qm74	8676	18	&	&	CC
cord-015021-pol2qm74	8676	19	B	B	NNP
cord-015021-pol2qm74	8676	20	(	(	-LRB-
cord-015021-pol2qm74	8676	21	p<0,01	p<0,01	NN
cord-015021-pol2qm74	8676	22	)	)	-RRB-
cord-015021-pol2qm74	8676	23	.	.	.
cord-015021-pol2qm74	8677	1	The	the	DT
cord-015021-pol2qm74	8677	2	regression	regression	NN
cord-015021-pol2qm74	8677	3	parameter	parameter	NN
cord-015021-pol2qm74	8677	4	R	r	NN
cord-015021-pol2qm74	8677	5	showed	show	VBD
cord-015021-pol2qm74	8677	6	no	no	DT
cord-015021-pol2qm74	8677	7	significant	significant	JJ
cord-015021-pol2qm74	8677	8	change	change	NN
cord-015021-pol2qm74	8677	9	in	in	IN
cord-015021-pol2qm74	8677	10	groups	group	NNS
cord-015021-pol2qm74	8677	11	A	A	NNP
cord-015021-pol2qm74	8677	12	&	&	CC
cord-015021-pol2qm74	8677	13	B	B	NNP
cord-015021-pol2qm74	8677	14	,	,	,
cord-015021-pol2qm74	8677	15	but	but	CC
cord-015021-pol2qm74	8677	16	a	a	DT
cord-015021-pol2qm74	8677	17	highly	highly	RB
cord-015021-pol2qm74	8677	18	significant	significant	JJ
cord-015021-pol2qm74	8677	19	decrease	decrease	NN
cord-015021-pol2qm74	8677	20	in	in	IN
cord-015021-pol2qm74	8677	21	group	group	NN
cord-015021-pol2qm74	8677	22	C	c	NN
cord-015021-pol2qm74	8677	23	starting	start	VBG
cord-015021-pol2qm74	8677	24	at	at	IN
cord-015021-pol2qm74	8677	25	day	day	NN
cord-015021-pol2qm74	8677	26	2	2	CD
cord-015021-pol2qm74	8677	27	(	(	-LRB-
cord-015021-pol2qm74	8677	28	p<0.005	p<0.005	JJ
cord-015021-pol2qm74	8677	29	)	)	-RRB-
cord-015021-pol2qm74	8677	30	,	,	,
cord-015021-pol2qm74	8677	31	thus	thus	RB
cord-015021-pol2qm74	8677	32	showing	show	VBG
cord-015021-pol2qm74	8677	33	a	a	DT
cord-015021-pol2qm74	8677	34	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8677	35	of	of	IN
cord-015021-pol2qm74	8677	36	the	the	DT
cord-015021-pol2qm74	8677	37	hepatic	hepatic	JJ
cord-015021-pol2qm74	8677	38	RES	res	NN
cord-015021-pol2qm74	8677	39	.	.	.
cord-015021-pol2qm74	8678	1	Conclusions	conclusion	NNS
cord-015021-pol2qm74	8678	2	:	:	:
cord-015021-pol2qm74	8679	1	Obstruction	obstruction	NN
cord-015021-pol2qm74	8679	2	of	of	IN
cord-015021-pol2qm74	8679	3	the	the	DT
cord-015021-pol2qm74	8679	4	hepatic	hepatic	JJ
cord-015021-pol2qm74	8679	5	or	or	CC
cord-015021-pol2qm74	8679	6	pancreatic	pancreatic	JJ
cord-015021-pol2qm74	8679	7	duct	duct	NN
cord-015021-pol2qm74	8679	8	alone	alone	RB
cord-015021-pol2qm74	8679	9	does	do	VBZ
cord-015021-pol2qm74	8679	10	no	no	DT
cord-015021-pol2qm74	8679	11	{	{	-LRB-
cord-015021-pol2qm74	8679	12	result	result	VB
cord-015021-pol2qm74	8679	13	in	in	IN
cord-015021-pol2qm74	8679	14	immediate	immediate	JJ
cord-015021-pol2qm74	8679	15	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8679	16	of	of	IN
cord-015021-pol2qm74	8679	17	the	the	DT
cord-015021-pol2qm74	8679	18	hepatic	hepatic	JJ
cord-015021-pol2qm74	8679	19	RES	res	NN
cord-015021-pol2qm74	8679	20	,	,	,
cord-015021-pol2qm74	8679	21	while	while	IN
cord-015021-pol2qm74	8679	22	obstruction	obstruction	NN
cord-015021-pol2qm74	8679	23	of	of	IN
cord-015021-pol2qm74	8679	24	beth	beth	NNP
cord-015021-pol2qm74	8679	25	ducts	duct	NNS
cord-015021-pol2qm74	8679	26	does	do	VBZ
cord-015021-pol2qm74	8679	27	.	.	.
cord-015021-pol2qm74	8680	1	Because	because	IN
cord-015021-pol2qm74	8680	2	only	only	JJ
cord-015021-pol2qm74	8680	3	ligation	ligation	NN
cord-015021-pol2qm74	8680	4	of	of	IN
cord-015021-pol2qm74	8680	5	both	both	DT
cord-015021-pol2qm74	8680	6	ducts	duct	NNS
cord-015021-pol2qm74	8680	7	is	be	VBZ
cord-015021-pol2qm74	8680	8	followed	follow	VBN
cord-015021-pol2qm74	8680	9	by	by	IN
cord-015021-pol2qm74	8680	10	a	a	DT
cord-015021-pol2qm74	8680	11	severe	severe	JJ
cord-015021-pol2qm74	8680	12	hereof	hereof	NN
cord-015021-pol2qm74	8680	13	..	..	.
cord-015021-pol2qm74	8681	1	rhagic	rhagic	NNP
cord-015021-pol2qm74	8681	2	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8681	3	,	,	,
cord-015021-pol2qm74	8681	4	RES	res	NN
cord-015021-pol2qm74	8681	5	dysfunction	dysfunction	NN
cord-015021-pol2qm74	8681	6	could	could	MD
cord-015021-pol2qm74	8681	7	be	be	VB
cord-015021-pol2qm74	8681	8	an	an	DT
cord-015021-pol2qm74	8681	9	important	important	JJ
cord-015021-pol2qm74	8681	10	factor	factor	NN
cord-015021-pol2qm74	8681	11	in	in	IN
cord-015021-pol2qm74	8681	12	the	the	DT
cord-015021-pol2qm74	8681	13	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8681	14	of	of	IN
cord-015021-pol2qm74	8681	15	pancreatitis	pancreatitis	NN
cord-015021-pol2qm74	8681	16	and	and	CC
cord-015021-pol2qm74	8681	17	resulting	result	VBG
cord-015021-pol2qm74	8681	18	organ	organ	NN
cord-015021-pol2qm74	8681	19	failure	failure	NN
cord-015021-pol2qm74	8681	20	.	.	.
cord-015021-pol2qm74	8682	1	Logarithmic	Logarithmic	NNP
cord-015021-pol2qm74	8682	2	regressinrL	regressinrL	NNP
cord-015021-pol2qm74	8682	3	has	have	VBZ
cord-015021-pol2qm74	8682	4	proven	prove	VBN
cord-015021-pol2qm74	8682	5	to	to	TO
cord-015021-pol2qm74	8682	6	be	be	VB
cord-015021-pol2qm74	8682	7	a	a	DT
cord-015021-pol2qm74	8682	8	valuable	valuable	JJ
cord-015021-pol2qm74	8682	9	tool	tool	NN
cord-015021-pol2qm74	8682	10	to	to	TO
cord-015021-pol2qm74	8682	11	analyse	analyse	VB
cord-015021-pol2qm74	8682	12	dynamic	dynamic	JJ
cord-015021-pol2qm74	8682	13	hepatic	hepatic	JJ
cord-015021-pol2qm74	8682	14	RES	res	NN
cord-015021-pol2qm74	8682	15	function	function	NN
cord-015021-pol2qm74	8682	16	.	.	.
cord-015021-pol2qm74	8683	1	(	(	-LRB-
cord-015021-pol2qm74	8683	2	B6	B6	NNP
cord-015021-pol2qm74	8683	3	)	)	-RRB-
cord-015021-pol2qm74	8683	4	in	in	IN
cord-015021-pol2qm74	8683	5	Lewis	Lewis	NNP
cord-015021-pol2qm74	8683	6	rats	rat	NNS
cord-015021-pol2qm74	8683	7	weighing	weigh	VBG
cord-015021-pol2qm74	8683	8	220	220	CD
cord-015021-pol2qm74	8683	9	-	-	SYM
cord-015021-pol2qm74	8683	10	250	250	CD
cord-015021-pol2qm74	8683	11	g	g	NN
cord-015021-pol2qm74	8683	12	.	.	.
cord-015021-pol2qm74	8684	1	There	there	EX
cord-015021-pol2qm74	8684	2	were	be	VBD
cord-015021-pol2qm74	8684	3	five	five	CD
cord-015021-pol2qm74	8684	4	groups	group	NNS
cord-015021-pol2qm74	8684	5	:	:	:
cord-015021-pol2qm74	8685	1	group	group	NNP
cord-015021-pol2qm74	8685	2	A	A	NNP
cord-015021-pol2qm74	8685	3	(	(	-LRB-
cord-015021-pol2qm74	8685	4	n=14	n=14	NN
cord-015021-pol2qm74	8685	5	)	)	-RRB-
cord-015021-pol2qm74	8685	6	were	be	VBD
cord-015021-pol2qm74	8685	7	untreated	untreated	JJ
cord-015021-pol2qm74	8685	8	controls	control	NNS
cord-015021-pol2qm74	8685	9	;	;	:
cord-015021-pol2qm74	8685	10	group	group	NN
cord-015021-pol2qm74	8685	11	B	B	NNP
cord-015021-pol2qm74	8685	12	(	(	-LRB-
cord-015021-pol2qm74	8685	13	n=7	n=7	NNS
cord-015021-pol2qm74	8685	14	)	)	-RRB-
cord-015021-pol2qm74	8685	15	were	be	VBD
cord-015021-pol2qm74	8685	16	given	give	VBN
cord-015021-pol2qm74	8685	17	isotonic	isotonic	JJ
cord-015021-pol2qm74	8685	18	saline	saline	NN
cord-015021-pol2qm74	8685	19	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	8685	20	and	and	CC
cord-015021-pol2qm74	8685	21	observed	observe	VBD
cord-015021-pol2qm74	8685	22	for	for	IN
cord-015021-pol2qm74	8685	23	48	48	CD
cord-015021-pol2qm74	8685	24	hours	hour	NNS
cord-015021-pol2qm74	8685	25	;	;	:
cord-015021-pol2qm74	8685	26	group	group	NN
cord-015021-pol2qm74	8685	27	C	C	NNP
cord-015021-pol2qm74	8685	28	(	(	-LRB-
cord-015021-pol2qm74	8685	29	n=7	n=7	NNP
cord-015021-pol2qm74	8685	30	)	)	-RRB-
cord-015021-pol2qm74	8685	31	2	2	CD
cord-015021-pol2qm74	8685	32	ml	ml	NN
cord-015021-pol2qm74	8685	33	x	x	NN
cord-015021-pol2qm74	8685	34	108	108	CD
cord-015021-pol2qm74	8685	35	E.	E.	NNP
cord-015021-pol2qm74	8685	36	coli	coli	NNS
cord-015021-pol2qm74	8685	37	intraperitoneally	intraperitoneally	RB
cord-015021-pol2qm74	8685	38	and	and	CC
cord-015021-pol2qm74	8685	39	observed	observe	VBD
cord-015021-pol2qm74	8685	40	for	for	IN
cord-015021-pol2qm74	8685	41	48	48	CD
cord-015021-pol2qm74	8685	42	hours	hour	NNS
cord-015021-pol2qm74	8685	43	;	;	:
cord-015021-pol2qm74	8685	44	group	group	NN
cord-015021-pol2qm74	8685	45	D	D	NNP
cord-015021-pol2qm74	8685	46	(	(	-LRB-
cord-015021-pol2qm74	8685	47	n=7	n=7	NNS
cord-015021-pol2qm74	8685	48	)	)	-RRB-
cord-015021-pol2qm74	8685	49	were	be	VBD
cord-015021-pol2qm74	8685	50	given	give	VBN
cord-015021-pol2qm74	8685	51	4	4	CD
cord-015021-pol2qm74	8685	52	ml	ml	NN
cord-015021-pol2qm74	8685	53	x	x	NN
cord-015021-pol2qm74	8685	54	108	108	CD
cord-015021-pol2qm74	8685	55	E.	E.	NNP
cord-015021-pol2qm74	8685	56	coli	coli	NNS
cord-015021-pol2qm74	8685	57	and	and	CC
cord-015021-pol2qm74	8685	58	observed	observe	VBD
cord-015021-pol2qm74	8685	59	for	for	IN
cord-015021-pol2qm74	8685	60	48	48	CD
cord-015021-pol2qm74	8685	61	hours	hour	NNS
cord-015021-pol2qm74	8685	62	;	;	:
cord-015021-pol2qm74	8685	63	group	group	NN
cord-015021-pol2qm74	8685	64	E	E	NNP
cord-015021-pol2qm74	8685	65	(	(	-LRB-
cord-015021-pol2qm74	8685	66	n=7	n=7	NNS
cord-015021-pol2qm74	8685	67	)	)	-RRB-
cord-015021-pol2qm74	8685	68	4	4	CD
cord-015021-pol2qm74	8685	69	ml	ml	NN
cord-015021-pol2qm74	8685	70	x	x	NN
cord-015021-pol2qm74	8685	71	i08	i08	NNP
cord-015021-pol2qm74	8685	72	E.	E.	NNP
cord-015021-pol2qm74	8685	73	coli	coli	NNS
cord-015021-pol2qm74	8685	74	and	and	CC
cord-015021-pol2qm74	8685	75	observed	observe	VBD
cord-015021-pol2qm74	8685	76	for	for	IN
cord-015021-pol2qm74	8685	77	24	24	CD
cord-015021-pol2qm74	8685	78	hours	hour	NNS
cord-015021-pol2qm74	8685	79	,	,	,
cord-015021-pol2qm74	8685	80	The	the	DT
cord-015021-pol2qm74	8685	81	rats	rat	NNS
cord-015021-pol2qm74	8685	82	were	be	VBD
cord-015021-pol2qm74	8685	83	than	than	IN
cord-015021-pol2qm74	8685	84	killed	kill	VBN
cord-015021-pol2qm74	8685	85	,	,	,
cord-015021-pol2qm74	8685	86	the	the	DT
cord-015021-pol2qm74	8685	87	spleens	spleen	NNS
cord-015021-pol2qm74	8685	88	were	be	VBD
cord-015021-pol2qm74	8685	89	removed	remove	VBN
cord-015021-pol2qm74	8685	90	and	and	CC
cord-015021-pol2qm74	8685	91	heparinised	heparinised	JJ
cord-015021-pol2qm74	8685	92	blood	blood	NN
cord-015021-pol2qm74	8685	93	taken	take	VBN
cord-015021-pol2qm74	8685	94	for	for	IN
cord-015021-pol2qm74	8685	95	immunological	immunological	JJ
cord-015021-pol2qm74	8685	96	tests	test	NNS
cord-015021-pol2qm74	8685	97	.	.	.
cord-015021-pol2qm74	8686	1	Total	total	JJ
cord-015021-pol2qm74	8686	2	T	T	NNP
cord-015021-pol2qm74	8686	3	-	-	HYPH
cord-015021-pol2qm74	8686	4	ceils	ceils	NNP
cord-015021-pol2qm74	8686	5	,	,	,
cord-015021-pol2qm74	8686	6	helper	helper	NN
cord-015021-pol2qm74	8686	7	T	T	NNP
cord-015021-pol2qm74	8686	8	-	-	HYPH
cord-015021-pol2qm74	8686	9	ceils	ceils	NNP
cord-015021-pol2qm74	8686	10	,	,	,
cord-015021-pol2qm74	8686	11	suppressor	suppressor	NN
cord-015021-pol2qm74	8686	12	T	t	NN
cord-015021-pol2qm74	8686	13	-	-	HYPH
cord-015021-pol2qm74	8686	14	cells	cell	NNS
cord-015021-pol2qm74	8686	15	,	,	,
cord-015021-pol2qm74	8686	16	monocytes	monocyte	NNS
cord-015021-pol2qm74	8686	17	,	,	,
cord-015021-pol2qm74	8686	18	and	and	CC
cord-015021-pol2qm74	8686	19	the	the	DT
cord-015021-pol2qm74	8686	20	interleukin	interleukin	NN
cord-015021-pol2qm74	8686	21	2	2	CD
cord-015021-pol2qm74	8686	22	receptor	receptor	NN
cord-015021-pol2qm74	8686	23	were	be	VBD
cord-015021-pol2qm74	8686	24	determined	determine	VBN
cord-015021-pol2qm74	8686	25	by	by	IN
cord-015021-pol2qm74	8686	26	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8686	27	antibodies	antibody	NNS
cord-015021-pol2qm74	8686	28	,	,	,
cord-015021-pol2qm74	8686	29	indirect	indirect	JJ
cord-015021-pol2qm74	8686	30	immunfluorescence	immunfluorescence	NN
cord-015021-pol2qm74	8686	31	,	,	,
cord-015021-pol2qm74	8686	32	and	and	CC
cord-015021-pol2qm74	8686	33	flow	flow	NN
cord-015021-pol2qm74	8686	34	cytometry	cytometry	NN
cord-015021-pol2qm74	8686	35	(	(	-LRB-
cord-015021-pol2qm74	8686	36	FACS	FACS	NNP
cord-015021-pol2qm74	8686	37	analyser	analyser	NN
cord-015021-pol2qm74	8686	38	11	11	CD
cord-015021-pol2qm74	8686	39	)	)	-RRB-
cord-015021-pol2qm74	8686	40	.	.	.
cord-015021-pol2qm74	8687	1	Statistical	statistical	JJ
cord-015021-pol2qm74	8687	2	analysis	analysis	NN
cord-015021-pol2qm74	8687	3	was	be	VBD
cord-015021-pol2qm74	8687	4	by	by	IN
cord-015021-pol2qm74	8687	5	the	the	DT
cord-015021-pol2qm74	8687	6	t	t	NNP
cord-015021-pol2qm74	8687	7	test	test	NN
cord-015021-pol2qm74	8687	8	on	on	IN
cord-015021-pol2qm74	8687	9	rank	rank	NN
cord-015021-pol2qm74	8687	10	transformed	transform	VBN
cord-015021-pol2qm74	8687	11	data	datum	NNS
cord-015021-pol2qm74	8687	12	.	.	.
cord-015021-pol2qm74	8688	1	In	in	IN
cord-015021-pol2qm74	8688	2	group	group	NN
cord-015021-pol2qm74	8688	3	B	b	NN
cord-015021-pol2qm74	8688	4	(	(	-LRB-
cord-015021-pol2qm74	8688	5	isotonic	isotonic	JJ
cord-015021-pol2qm74	8688	6	saline	saline	NN
cord-015021-pol2qm74	8688	7	)	)	-RRB-
cord-015021-pol2qm74	8688	8	the	the	DT
cord-015021-pol2qm74	8688	9	total	total	JJ
cord-015021-pol2qm74	8688	10	T	T	NNP
cord-015021-pol2qm74	8688	11	-	-	HYPH
cord-015021-pol2qm74	8688	12	ceils	ceils	NNP
cord-015021-pol2qm74	8688	13	increased	increase	VBD
cord-015021-pol2qm74	8688	14	in	in	IN
cord-015021-pol2qm74	8688	15	the	the	DT
cord-015021-pol2qm74	8688	16	blood	blood	NN
cord-015021-pol2qm74	8688	17	(	(	-LRB-
cord-015021-pol2qm74	8688	18	p=0,003	p=0,003	NN
cord-015021-pol2qm74	8688	19	)	)	-RRB-
cord-015021-pol2qm74	8688	20	and	and	CC
cord-015021-pol2qm74	8688	21	spleen	spleen	NNS
cord-015021-pol2qm74	8688	22	(	(	-LRB-
cord-015021-pol2qm74	8688	23	p=0,0001	p=0,0001	NNP
cord-015021-pol2qm74	8688	24	)	)	-RRB-
cord-015021-pol2qm74	8688	25	com	com	NN
cord-015021-pol2qm74	8688	26	pared	pare	VBN
cord-015021-pol2qm74	8688	27	with	with	IN
cord-015021-pol2qm74	8688	28	the	the	DT
cord-015021-pol2qm74	8688	29	untreated	untreated	JJ
cord-015021-pol2qm74	8688	30	rats	rat	NNS
cord-015021-pol2qm74	8688	31	(	(	-LRB-
cord-015021-pol2qm74	8688	32	group	group	NN
cord-015021-pol2qm74	8688	33	A	A	NNP
cord-015021-pol2qm74	8688	34	)	)	-RRB-
cord-015021-pol2qm74	8689	1	,	,	,
cord-015021-pol2qm74	8689	2	In	in	IN
cord-015021-pol2qm74	8689	3	the	the	DT
cord-015021-pol2qm74	8689	4	groups	group	NNS
cord-015021-pol2qm74	8689	5	with	with	IN
cord-015021-pol2qm74	8689	6	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8689	7	(	(	-LRB-
cord-015021-pol2qm74	8689	8	C	C	NNP
cord-015021-pol2qm74	8689	9	,	,	,
cord-015021-pol2qm74	8689	10	D	D	NNP
cord-015021-pol2qm74	8689	11	,	,	,
cord-015021-pol2qm74	8689	12	and	and	CC
cord-015021-pol2qm74	8689	13	E	e	LS
cord-015021-pol2qm74	8689	14	)	)	-RRB-
cord-015021-pol2qm74	8689	15	we	-PRON-	PRP
cord-015021-pol2qm74	8689	16	found	find	VBD
cord-015021-pol2qm74	8689	17	highly	highly	RB
cord-015021-pol2qm74	8689	18	significant	significant	JJ
cord-015021-pol2qm74	8689	19	rises	rise	NNS
cord-015021-pol2qm74	8689	20	in	in	IN
cord-015021-pol2qm74	8689	21	suppressor	suppressor	NN
cord-015021-pol2qm74	8689	22	T	T	NNP
cord-015021-pol2qm74	8689	23	-	-	HYPH
cord-015021-pol2qm74	8689	24	cells	cell	NNS
cord-015021-pol2qm74	8689	25	in	in	IN
cord-015021-pol2qm74	8689	26	the	the	DT
cord-015021-pol2qm74	8689	27	blood	blood	NN
cord-015021-pol2qm74	8689	28	and	and	CC
cord-015021-pol2qm74	8689	29	spleen	spleen	NNS
cord-015021-pol2qm74	8689	30	(	(	-LRB-
cord-015021-pol2qm74	8689	31	both	both	DT
cord-015021-pol2qm74	8689	32	p<0,0001	p<0,0001	CD
cord-015021-pol2qm74	8689	33	)	)	-RRB-
cord-015021-pol2qm74	8689	34	compared	compare	VBN
cord-015021-pol2qm74	8689	35	with	with	IN
cord-015021-pol2qm74	8689	36	the	the	DT
cord-015021-pol2qm74	8689	37	non	non	JJ
cord-015021-pol2qm74	8689	38	-	-	JJ
cord-015021-pol2qm74	8689	39	infected	infected	JJ
cord-015021-pol2qm74	8689	40	control	control	NN
cord-015021-pol2qm74	8689	41	groups	group	NNS
cord-015021-pol2qm74	8689	42	A	A	NNP
cord-015021-pol2qm74	8689	43	and	and	CC
cord-015021-pol2qm74	8690	1	B.	B.	NNP
cord-015021-pol2qm74	8690	2	This	this	DT
cord-015021-pol2qm74	8690	3	increase	increase	NN
cord-015021-pol2qm74	8690	4	was	be	VBD
cord-015021-pol2qm74	8690	5	significantly	significantly	RB
cord-015021-pol2qm74	8690	6	higher	high	JJR
cord-015021-pol2qm74	8690	7	in	in	IN
cord-015021-pol2qm74	8690	8	group	group	NN
cord-015021-pol2qm74	8690	9	D	d	NN
cord-015021-pol2qm74	8690	10	than	than	IN
cord-015021-pol2qm74	8690	11	in	in	IN
cord-015021-pol2qm74	8690	12	groups	group	NNS
cord-015021-pol2qm74	8690	13	C	C	NNP
cord-015021-pol2qm74	8690	14	and	and	CC
cord-015021-pol2qm74	8690	15	E.	E.	NNP
cord-015021-pol2qm74	8690	16	As	as	RB
cord-015021-pol2qm74	8690	17	well	well	RB
cord-015021-pol2qm74	8690	18	as	as	IN
cord-015021-pol2qm74	8690	19	other	other	JJ
cord-015021-pol2qm74	8690	20	alterations	alteration	NNS
cord-015021-pol2qm74	8690	21	,	,	,
cord-015021-pol2qm74	8690	22	we	-PRON-	PRP
cord-015021-pol2qm74	8690	23	found	find	VBD
cord-015021-pol2qm74	8690	24	a	a	DT
cord-015021-pol2qm74	8690	25	uniform	uniform	JJ
cord-015021-pol2qm74	8690	26	increase	increase	NN
cord-015021-pol2qm74	8690	27	in	in	IN
cord-015021-pol2qm74	8690	28	the	the	DT
cord-015021-pol2qm74	8690	29	number	number	NN
cord-015021-pol2qm74	8690	30	of	of	IN
cord-015021-pol2qm74	8690	31	T	T	NNP
cord-015021-pol2qm74	8690	32	suppressor	suppressor	NN
cord-015021-pol2qm74	8690	33	ceils	ceil	NNS
cord-015021-pol2qm74	8690	34	in	in	IN
cord-015021-pol2qm74	8690	35	our	-PRON-	PRP$
cord-015021-pol2qm74	8690	36	model	model	NN
cord-015021-pol2qm74	8690	37	of	of	IN
cord-015021-pol2qm74	8690	38	acute	acute	JJ
cord-015021-pol2qm74	8690	39	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8690	40	that	that	WDT
cord-015021-pol2qm74	8690	41	was	be	VBD
cord-015021-pol2qm74	8690	42	both	both	DT
cord-015021-pol2qm74	8690	43	time	time	NN
cord-015021-pol2qm74	8690	44	and	and	CC
cord-015021-pol2qm74	8690	45	dose	dose	NN
cord-015021-pol2qm74	8690	46	dependent	dependent	JJ
cord-015021-pol2qm74	8690	47	,	,	,
cord-015021-pol2qm74	8690	48	Department	Department	NNP
cord-015021-pol2qm74	8690	49	of	of	IN
cord-015021-pol2qm74	8690	50	Surgery	Surgery	NNP
cord-015021-pol2qm74	8690	51	,	,	,
cord-015021-pol2qm74	8690	52	University	University	NNP
cord-015021-pol2qm74	8690	53	Vienna	Vienna	NNP
cord-015021-pol2qm74	8690	54	,	,	,
cord-015021-pol2qm74	8690	55	AKH	AKH	NNP
cord-015021-pol2qm74	8690	56	Wien	Wien	NNP
cord-015021-pol2qm74	8690	57	,	,	,
cord-015021-pol2qm74	8690	58	W	W	NNP
cord-015021-pol2qm74	8690	59	~	~	CD
cord-015021-pol2qm74	8690	60	hringer	hringer	NN
cord-015021-pol2qm74	8690	61	Gurtel	Gurtel	NNP
cord-015021-pol2qm74	8690	62	18	18	CD
cord-015021-pol2qm74	8690	63	-	-	SYM
cord-015021-pol2qm74	8690	64	20	20	CD
cord-015021-pol2qm74	8690	65	,	,	,
cord-015021-pol2qm74	8690	66	1090	1090	CD
cord-015021-pol2qm74	8690	67	Wien	Wien	NNP
cord-015021-pol2qm74	8690	68	.	.	.
cord-015021-pol2qm74	8691	1	D~'na~'aics	d~'na~'aic	NNS
cord-015021-pol2qm74	8691	2	of	of	IN
cord-015021-pol2qm74	8691	3	Som~	som~	NN
cord-015021-pol2qm74	8692	1	l	l	NNP
cord-015021-pol2qm74	8692	2	~	~	NFP
cord-015021-pol2qm74	8692	3	mnunologic	mnunologic	NNP
cord-015021-pol2qm74	8692	4	Indices	Indices	NNPS
cord-015021-pol2qm74	8692	5	in	in	IN
cord-015021-pol2qm74	8692	6	Children	Children	NNP
cord-015021-pol2qm74	8692	7	with	with	IN
cord-015021-pol2qm74	8692	8	Abdo;~tinal	Abdo;~tinal	NNP
cord-015021-pol2qm74	8692	9	Shock	Shock	NNP
cord-015021-pol2qm74	8693	1	V.Z.i	v.z.i	CC
cord-015021-pol2qm74	8693	2	~	~	NFP
cord-015021-pol2qm74	8693	3	ioskalenko	ioskalenko	NNP
cord-015021-pol2qm74	8693	4	,	,	,
cord-015021-pol2qm74	8693	5	S.F.Vesiol$,T.V.P	s.f.vesiol$,t.v.p	NN
cord-015021-pol2qm74	8694	1	~bina	~bina	NNP
cord-015021-pol2qm74	8694	2	Serum	serum	NN
cord-015021-pol2qm74	8694	3	(	(	-LRB-
cord-015021-pol2qm74	8694	4	IgA,:~I	iga,:~i	NN
cord-015021-pol2qm74	8694	5	,	,	,
cord-015021-pol2qm74	8694	6	G	g	NN
cord-015021-pol2qm74	8694	7	,	,	,
cord-015021-pol2qm74	8694	8	circulating	circulate	VBG
cord-015021-pol2qm74	8694	9	imaune	imaune	NNP
cord-015021-pol2qm74	8694	10	co!~plexes	co!~plexes	NNP
cord-015021-pol2qm74	8694	11	,	,	,
cord-015021-pol2qm74	8694	12	co	co	VBD
cord-015021-pol2qm74	8694	13	:	:	:
cord-015021-pol2qm74	8694	14	apleaentary	apleaentary	JJ
cord-015021-pol2qm74	8694	15	serum	serum	NN
cord-015021-pol2qm74	8694	16	activity	activity	NN
cord-015021-pol2qm74	8694	17	,	,	,
cord-015021-pol2qm74	8694	18	antimesothelialvisceral	antimesothelialvisceral	JJ
cord-015021-pol2qm74	8694	19	and	and	CC
cord-015021-pol2qm74	8694	20	parietal	parietal	JJ
cord-015021-pol2qm74	8694	21	antibodies	antibody	NNS
cord-015021-pol2qm74	8694	22	)	)	-RRB-
cord-015021-pol2qm74	8694	23	and	and	CC
cord-015021-pol2qm74	8694	24	cellular	cellular	JJ
cord-015021-pol2qm74	8694	25	(	(	-LRB-
cord-015021-pol2qm74	8694	26	i	i	NN
cord-015021-pol2qm74	8694	27	-	-	HYPH
cord-015021-pol2qm74	8694	28	l	l	NNP
cord-015021-pol2qm74	8695	1	~q	~q	NNP
cord-015021-pol2qm74	8695	2	~	~	NFP
cord-015021-pol2qm74	8695	3	hocytes	hocytes	NNP
cord-015021-pol2qm74	8695	4	,	,	,
cord-015021-pol2qm74	8696	1	~s	~s	NNP
cord-015021-pol2qm74	8697	1	/	/	NFP
cord-015021-pol2qm74	8698	1	Th	th	JJ
cord-015021-pol2qm74	8698	2	,	,	,
cord-015021-pol2qm74	8698	3	B	b	NN
cord-015021-pol2qm74	8698	4	-	-	HYPH
cord-015021-pol2qm74	8698	5	lyaphoeytes	lyaphoeytes	NNP
cord-015021-pol2qm74	8698	6	,	,	,
cord-015021-pol2qm74	8698	7	i	i	PRP
cord-015021-pol2qm74	8698	8	nLaunoleukosis	nLaunoleukosis	NNP
cord-015021-pol2qm74	8698	9	to	to	IN
cord-015021-pol2qm74	8698	10	aesothelial	aesothelial	JJ
cord-015021-pol2qm74	8698	11	allergens	allergen	NNS
cord-015021-pol2qm74	8698	12	;	;	:
cord-015021-pol2qm74	8698	13	spontaneous	spontaneous	JJ
cord-015021-pol2qm74	8698	14	blast	blast	NN
cord-015021-pol2qm74	8698	15	cell	cell	NN
cord-015021-pol2qm74	8698	16	transformation	transformation	NN
cord-015021-pol2qm74	8698	17	to	to	IN
cord-015021-pol2qm74	8698	18	phytohemaaglutinin	phytohemaaglutinin	NNS
cord-015021-pol2qm74	8698	19	and	and	CC
cord-015021-pol2qm74	8698	20	.nesoth<-~lial	.nesoth<-~lial	CD
cord-015021-pol2qm74	8698	21	~,togen	~,togen	NNP
cord-015021-pol2qm74	8698	22	;	;	:
cord-015021-pol2qm74	8698	23	phagooFtic	phagooftic	JJ
cord-015021-pol2qm74	8698	24	neutrophil	neutrophil	NN
cord-015021-pol2qm74	8698	25	activity	activity	NN
cord-015021-pol2qm74	8698	26	)	)	-RRB-
cord-015021-pol2qm74	8699	1	im:~une	im:~une	NNP
cord-015021-pol2qm74	8699	2	indices	index	NNS
cord-015021-pol2qm74	8699	3	v.	v.	XX
cord-015021-pol2qm74	8700	1	'	'	``
cord-015021-pol2qm74	8700	2	ere	ere	VBP
cord-015021-pol2qm74	8700	3	studied	study	VBN
cord-015021-pol2qm74	8700	4	in	in	IN
cord-015021-pol2qm74	8700	5	60	60	CD
cord-015021-pol2qm74	8700	6	children	child	NNS
cord-015021-pol2qm74	8700	7	operated	operate	VBD
cord-015021-pol2qm74	8700	8	v	v	NN
cord-015021-pol2qm74	8700	9	:	:	:
cord-015021-pol2qm74	8700	10	ith	ith	NNP
cord-015021-pol2qm74	8700	11	symi	symi	NNP
cord-015021-pol2qm74	8700	12	~	~	NFP
cord-015021-pol2qm74	8700	13	to'as	to'as	NNP
cord-015021-pol2qm74	8700	14	of	of	IN
cord-015021-pol2qm74	8700	15	abdo	abdo	NNP
cord-015021-pol2qm74	8700	16	~	~	NFP
cord-015021-pol2qm74	8700	17	ainal	ainal	NNP
cord-015021-pol2qm74	8700	18	shock	shock	NN
cord-015021-pol2qm74	8700	19	.	.	.
cord-015021-pol2qm74	8701	1	,	,	,
cord-015021-pol2qm74	8701	2	'	'	``
cord-015021-pol2qm74	8701	3	~!-~	~!-~	NN
cord-015021-pol2qm74	8701	4	of	of	IN
cord-015021-pol2qm74	8701	5	them	-PRON-	PRP
cord-015021-pol2qm74	8701	6	had	have	VBD
cord-015021-pol2qm74	8701	7	appendicnlar(26	appendicnlar(26	NNP
cord-015021-pol2qm74	8702	1	-1ocalized	-1ocalized	JJ
cord-015021-pol2qm74	8702	2	JO	JO	NNP
cord-015021-pol2qm74	8702	3	-	-	HYPH
cord-015021-pol2qm74	8702	4	diffuse	diffuse	NNP
cord-015021-pol2qm74	8702	5	,	,	,
cord-015021-pol2qm74	8702	6	9-~eneralized	9-~eneralized	CD
cord-015021-pol2qm74	8702	7	)	)	-RRB-
cord-015021-pol2qm74	8702	8	and	and	CC
cord-015021-pol2qm74	8702	9	5-hemoperitoni-~is	5-hemoperitoni-~is	LS
cord-015021-pol2qm74	8702	10	(	(	-LRB-
cord-015021-pol2qm74	8702	11	dull	dull	JJ
cord-015021-pol2qm74	8702	12	abdominal	abdominal	JJ
cord-015021-pol2qm74	8702	13	trau;na	trau;na	NN
cord-015021-pol2qm74	8702	14	with	with	IN
cord-015021-pol2qm74	8702	15	injayy	injayy	NN
cord-015021-pol2qm74	8702	16	of	of	IN
cord-015021-pol2qm74	8702	17	'	'	''
cord-015021-pol2qm74	8702	18	the	the	DT
cord-015021-pol2qm74	8702	19	spleen-4	spleen-4	NNP
cord-015021-pol2qm74	8702	20	,	,	,
cord-015021-pol2qm74	8702	21	the	the	DT
cord-015021-pol2qm74	8702	22	spleen	spleen	NN
cord-015021-pol2qm74	8702	23	and	and	CC
cord-015021-pol2qm74	8702	24	liver	liver	NN
cord-015021-pol2qm74	8702	25	-	-	HYPH
cord-015021-pol2qm74	8702	26	q	q	NN
cord-015021-pol2qm74	8702	27	)	)	-RRB-
cord-015021-pol2qm74	8703	1	,	,	,
cord-015021-pol2qm74	8703	2	flO	flo	JJ
cord-015021-pol2qm74	8703	3	patients	patient	NNS
cord-015021-pol2qm74	8703	4	tJere	tJere	NNP
cord-015021-pol2qm74	8703	5	operated	operate	VBD
cord-015021-pol2qm74	8703	6	on	on	IN
cord-015021-pol2qm74	8703	7	for	for	IN
cord-015021-pol2qm74	8703	8	co~	co~	XX
cord-015021-pol2qm74	8704	1	Iplete	Iplete	NNP
cord-015021-pol2qm74	8704	2	iieus	iieu	NNS
cord-015021-pol2qm74	8704	3	(	(	-LRB-
cord-015021-pol2qm74	8704	4	~-intussnsc.sption	~-intussnsc.sption	NN
cord-015021-pol2qm74	8704	5	,	,	,
cord-015021-pol2qm74	8704	6	5-com	5-com	NNP
cord-015021-pol2qm74	8704	7	:	:	:
cord-015021-pol2qm74	8704	8	lissural	lissural	NNP
cord-015021-pol2qm74	8704	9	ileus	ileus	NNP
cord-015021-pol2qm74	8704	10	)	)	-RRB-
cord-015021-pol2qm74	8704	11	.	.	.
cord-015021-pol2qm74	8705	1	2he	2he	NNP
cord-015021-pol2qm74	8706	1	follo~'~ing	follo~'~e	VBG
cord-015021-pol2qm74	8706	2	serum	serum	NN
cord-015021-pol2qm74	8706	3	factors	factor	NNS
cord-015021-pol2qm74	8706	4	:	:	:
cord-015021-pol2qm74	8706	5	cireula:;ing	cireula:;e	VBG
cord-015021-pol2qm74	8706	6	im~	im~	NNP
cord-015021-pol2qm74	8707	1	aune	aune	NNP
cord-015021-pol2qm74	8707	2	complexes	complex	NNS
cord-015021-pol2qm74	8707	3	and	and	CC
cord-015021-pol2qm74	8707	4	~).esothelial	~).esothelial	CD
cord-015021-pol2qm74	8707	5	antibodies	antibody	NNS
cord-015021-pol2qm74	8707	6	are	be	VBP
cord-015021-pol2qm74	8707	7	the	the	DT
cord-015021-pol2qm74	8707	8	aost	aost	NN
cord-015021-pol2qm74	8708	1	i~	i~	CD
cord-015021-pol2qm74	8709	1	portant	portant	JJ
cord-015021-pol2qm74	8710	1	~ar~	~ar~	NNS
cord-015021-pol2qm74	8711	1	ers	er	NNS
cord-015021-pol2qm74	8711	2	of	of	IN
cord-015021-pol2qm74	8711	3	the	the	DT
cord-015021-pol2qm74	8711	4	abdominal	abdominal	JJ
cord-015021-pol2qm74	8711	5	shock	shock	NN
cord-015021-pol2qm74	8711	6	course	course	NN
cord-015021-pol2qm74	8711	7	.	.	.
cord-015021-pol2qm74	8712	1	:	:	:
cord-015021-pol2qm74	8713	1	Yith	yith	VB
cord-015021-pol2qm74	8713	2	the	the	DT
cord-015021-pol2qm74	8713	3	progress	progress	NN
cord-015021-pol2qm74	8713	4	of	of	IN
cord-015021-pol2qm74	8713	5	the	the	DT
cord-015021-pol2qm74	8713	6	process	process	NN
cord-015021-pol2qm74	8713	7	the	the	DT
cord-015021-pol2qm74	8713	8	indices	index	NNS
cord-015021-pol2qm74	8713	9	increase	increase	VBP
cord-015021-pol2qm74	8713	10	irresponsive	irresponsive	JJ
cord-015021-pol2qm74	8713	11	of	of	IN
cord-015021-pol2qm74	8713	12	t.	t.	NNP
cord-015021-pol2qm74	8714	1	L	L	NNP
cord-015021-pol2qm74	8714	2	~	~	NFP
cord-015021-pol2qm74	8714	3	e	e	XX
cord-015021-pol2qm74	8714	4	cha±.aeter	cha±.aeter	NN
cord-015021-pol2qm74	8714	5	of	of	IN
cord-015021-pol2qm74	8714	6	pathology	pathology	NN
cord-015021-pol2qm74	8714	7	.	.	.
cord-015021-pol2qm74	8715	1	In	in	IN
cord-015021-pol2qm74	8715	2	case	case	NN
cord-015021-pol2qm74	8715	3	of	of	IN
cord-015021-pol2qm74	8715	4	ileus	ileus	NNP
cord-015021-pol2qm74	8715	5	regress	regress	VBP
cord-015021-pol2qm74	8715	6	and	and	CC
cord-015021-pol2qm74	8715	7	hemoperitonotis	hemoperitonotis	NNP
cord-015021-pol2qm74	8715	8	an	an	DT
cord-015021-pol2qm74	8715	9	abrupt	abrupt	JJ
cord-015021-pol2qm74	8715	10	drop	drop	NN
cord-015021-pol2qm74	8715	11	in	in	IN
cord-015021-pol2qm74	8715	12	~he	~he	NNP
cord-015021-pol2qm74	8715	13	titer	titer	NN
cord-015021-pol2qm74	8715	14	of	of	IN
cord-015021-pol2qm74	8715	15	anti	anti	NNP
cord-015021-pol2qm74	8715	16	~	~	NNP
cord-015021-pol2qm74	8715	17	aesothelial	aesothelial	JJ
cord-015021-pol2qm74	8715	18	antibodies	antibody	NNS
cord-015021-pol2qm74	8715	19	is	be	VBZ
cord-015021-pol2qm74	8715	20	noted	note	VBN
cord-015021-pol2qm74	8715	21	.	.	.
cord-015021-pol2qm74	8716	1	In	in	IN
cord-015021-pol2qm74	8716	2	bacterial	bacterial	JJ
cord-015021-pol2qm74	8716	3	peritonitis	peritonitis	NN
cord-015021-pol2qm74	8716	4	a	a	DT
cord-015021-pol2qm74	8716	5	high	high	JJ
cord-015021-pol2qm74	8716	6	~iter	~iter	NN
cord-015021-pol2qm74	8716	7	of	of	IN
cord-015021-pol2qm74	8716	8	anti	anti	JJ
cord-015021-pol2qm74	8716	9	:	:	NNP
cord-015021-pol2qm74	8716	10	aesothelial	aesothelial	JJ
cord-015021-pol2qm74	8716	11	parietal	parietal	JJ
cord-015021-pol2qm74	8716	12	antibodies	antibody	NNS
cord-015021-pol2qm74	8716	13	in	in	IN
cord-015021-pol2qm74	8716	14	great	great	JJ
cord-015021-pol2qm74	8716	15	dilutions	dilution	NNS
cord-015021-pol2qm74	8717	1	(	(	-LRB-
cord-015021-pol2qm74	8717	2	"	"	``
cord-015021-pol2qm74	8717	3	+	+	CC
cord-015021-pol2qm74	8717	4	+	+	CC
cord-015021-pol2qm74	8718	1	+	+	CC
cord-015021-pol2qm74	8718	2	"	"	``
cord-015021-pol2qm74	8718	3	,	,	,
cord-015021-pol2qm74	8718	4	"	"	''
cord-015021-pol2qm74	8719	1	+	+	CC
cord-015021-pol2qm74	8720	1	+	+	CC
cord-015021-pol2qm74	8721	1	+	+	CC
cord-015021-pol2qm74	8721	2	+	+	CC
cord-015021-pol2qm74	8722	1	"	"	``
cord-015021-pol2qm74	8722	2	-q	-q	NNS
cord-015021-pol2qm74	8722	3	;	;	:
cord-015021-pol2qm74	8722	4	720	720	CD
cord-015021-pol2qm74	8722	5	)	)	-RRB-
cord-015021-pol2qm74	8722	6	persisted	persist	VBD
cord-015021-pol2qm74	8722	7	even	even	RB
cord-015021-pol2qm74	8722	8	in	in	IN
cord-015021-pol2qm74	8722	9	the	the	DT
cord-015021-pol2qm74	8722	10	period	period	NN
cord-015021-pol2qm74	8722	11	of	of	IN
cord-015021-pol2qm74	8722	12	clinical	clinical	JJ
cord-015021-pol2qm74	8722	13	recovery	recovery	NN
cord-015021-pol2qm74	8722	14	.	.	.
cord-015021-pol2qm74	8723	1	Cellular	cellular	JJ
cord-015021-pol2qm74	8723	2	factors	factor	NNS
cord-015021-pol2qm74	8724	1	cham'acterize	cham'acterize	IN
cord-015021-pol2qm74	8724	2	dFnaaics	dfnaaic	NNS
cord-015021-pol2qm74	8724	3	of	of	IN
cord-015021-pol2qm74	8724	4	the	the	DT
cord-015021-pol2qm74	8724	5	abdominal	abdominal	JJ
cord-015021-pol2qm74	8724	6	shock	shock	NN
cord-015021-pol2qm74	8724	7	coulees	coulee	NNS
cord-015021-pol2qm74	8725	1	less	less	RBR
cord-015021-pol2qm74	8725	2	specifically	specifically	RB
cord-015021-pol2qm74	8725	3	Llast	Llast	NNP
cord-015021-pol2qm74	8725	4	cell	cell	NN
cord-015021-pol2qm74	8725	5	transfor	transfor	NNP
cord-015021-pol2qm74	8725	6	~	~	NFP
cord-015021-pol2qm74	8725	7	aation	aation	NNP
cord-015021-pol2qm74	8725	8	and	and	CC
cord-015021-pol2qm74	8725	9	phagocyue	phagocyue	NNP
cord-015021-pol2qm74	8725	10	neut	neut	NNP
cord-015021-pol2qm74	8726	1	~ophil	~ophil	JJ
cord-015021-pol2qm74	8726	2	activit	activit	NN
cord-015021-pol2qm74	8726	3	2	2	CD
cord-015021-pol2qm74	8726	4	can	can	MD
cord-015021-pol2qm74	8726	5	inderectly	inderectly	RB
cord-015021-pol2qm74	8726	6	characterize	characterize	VB
cord-015021-pol2qm74	8726	7	transition	transition	NN
cord-015021-pol2qm74	8726	8	of	of	IN
cord-015021-pol2qm74	8726	9	shock	shock	NN
cord-015021-pol2qm74	8726	10	f	f	NNP
cord-015021-pol2qm74	8726	11	~	~	NFP
cord-015021-pol2qm74	8726	12	orn	orn	XX
cord-015021-pol2qm74	8726	13	reversible	reversible	JJ
cord-015021-pol2qm74	8726	14	into	into	IN
cord-015021-pol2qm74	8726	15	irreversible	irreversible	JJ
cord-015021-pol2qm74	8726	16	phases	phase	NNS
cord-015021-pol2qm74	8726	17	.	.	.
cord-015021-pol2qm74	8727	1	The	the	DT
cord-015021-pol2qm74	8727	2	past	past	NN
cord-015021-pol2qm74	8727	3	SO	so	JJ
cord-015021-pol2qm74	8727	4	years	year	NNS
cord-015021-pol2qm74	8727	5	have	have	VBP
cord-015021-pol2qm74	8727	6	brought	bring	VBN
cord-015021-pol2qm74	8727	7	a	a	DT
cord-015021-pol2qm74	8727	8	number	number	NN
cord-015021-pol2qm74	8727	9	of	of	IN
cord-015021-pol2qm74	8727	10	major	major	JJ
cord-015021-pol2qm74	8727	11	advances	advance	NNS
cord-015021-pol2qm74	8727	12	in	in	IN
cord-015021-pol2qm74	8727	13	burn	burn	NN
cord-015021-pol2qm74	8727	14	care	care	NN
cord-015021-pol2qm74	8727	15	.	.	.
cord-015021-pol2qm74	8728	1	The	the	DT
cord-015021-pol2qm74	8728	2	initial	initial	JJ
cord-015021-pol2qm74	8728	3	advance	advance	NN
cord-015021-pol2qm74	8728	4	was	be	VBD
cord-015021-pol2qm74	8728	5	the	the	DT
cord-015021-pol2qm74	8728	6	discovery	discovery	NN
cord-015021-pol2qm74	8728	7	that	that	WDT
cord-015021-pol2qm74	8728	8	burn	burn	VBP
cord-015021-pol2qm74	8728	9	victims	victim	NNS
cord-015021-pol2qm74	8728	10	required	require	VBD
cord-015021-pol2qm74	8728	11	large	large	JJ
cord-015021-pol2qm74	8728	12	volumes	volume	NNS
cord-015021-pol2qm74	8728	13	of	of	IN
cord-015021-pol2qm74	8728	14	resuscitation	resuscitation	NN
cord-015021-pol2qm74	8728	15	fluid	fluid	NN
cord-015021-pol2qm74	8728	16	in	in	IN
cord-015021-pol2qm74	8728	17	the	the	DT
cord-015021-pol2qm74	8728	18	initial	initial	JJ
cord-015021-pol2qm74	8728	19	24	24	CD
cord-015021-pol2qm74	8728	20	hours	hour	NNS
cord-015021-pol2qm74	8728	21	to	to	TO
cord-015021-pol2qm74	8728	22	maintain	maintain	VB
cord-015021-pol2qm74	8728	23	hsmodynamic	hsmodynamic	JJ
cord-015021-pol2qm74	8728	24	stability	stability	NN
cord-015021-pol2qm74	8728	25	,	,	,
cord-015021-pol2qm74	8728	26	This	this	DT
cord-015021-pol2qm74	8728	27	was	be	VBD
cord-015021-pol2qm74	8728	28	followed	follow	VBN
cord-015021-pol2qm74	8728	29	hy	hy	NNP
cord-015021-pol2qm74	8728	30	the	the	DT
cord-015021-pol2qm74	8728	31	dsvelopmsnt	dsvelopmsnt	NN
cord-015021-pol2qm74	8728	32	of	of	IN
cord-015021-pol2qm74	8728	33	topical	topical	JJ
cord-015021-pol2qm74	8728	34	antimicrohlal	antimicrohlal	NN
cord-015021-pol2qm74	8728	35	agents	agent	NNS
cord-015021-pol2qm74	8728	36	to	to	TO
cord-015021-pol2qm74	8728	37	prevent	prevent	VB
cord-015021-pol2qm74	8728	38	end	end	NN
cord-015021-pol2qm74	8728	39	treat	treat	NN
cord-015021-pol2qm74	8728	40	infections	infection	NNS
cord-015021-pol2qm74	8728	41	.	.	.
cord-015021-pol2qm74	8729	1	Next	next	RB
cord-015021-pol2qm74	8729	2	,	,	,
cord-015021-pol2qm74	8729	3	was	be	VBD
cord-015021-pol2qm74	8729	4	the	the	DT
cord-015021-pol2qm74	8729	5	reporting	reporting	NN
cord-015021-pol2qm74	8729	6	that	that	IN
cord-015021-pol2qm74	8729	7	early	early	JJ
cord-015021-pol2qm74	8729	8	excision	excision	NN
cord-015021-pol2qm74	8729	9	of	of	IN
cord-015021-pol2qm74	8729	10	burn	burn	NN
cord-015021-pol2qm74	8729	11	wounds	wound	NNS
cord-015021-pol2qm74	8729	12	,	,	,
cord-015021-pol2qm74	8729	13	with	with	IN
cord-015021-pol2qm74	8729	14	autografting	autografting	NN
cord-015021-pol2qm74	8729	15	of	of	IN
cord-015021-pol2qm74	8729	16	the	the	DT
cord-015021-pol2qm74	8729	17	excised	excise	VBN
cord-015021-pol2qm74	8729	18	wounds	wound	NNS
cord-015021-pol2qm74	8729	19	was	be	VBD
cord-015021-pol2qm74	8729	20	possible	possible	JJ
cord-015021-pol2qm74	8729	21	.	.	.
cord-015021-pol2qm74	8730	1	Finally	finally	RB
cord-015021-pol2qm74	8730	2	,	,	,
cord-015021-pol2qm74	8730	3	was	be	VBD
cord-015021-pol2qm74	8730	4	the	the	DT
cord-015021-pol2qm74	8730	5	identification	identification	NN
cord-015021-pol2qm74	8730	6	of	of	IN
cord-015021-pol2qm74	8730	7	the	the	DT
cord-015021-pol2qm74	8730	8	importance	importance	NN
cord-015021-pol2qm74	8730	9	of	of	IN
cord-015021-pol2qm74	8730	10	aggrsssive	aggrsssive	JJ
cord-015021-pol2qm74	8730	11	nutritional	nutritional	JJ
cord-015021-pol2qm74	8730	12	support	support	NN
cord-015021-pol2qm74	8730	13	for	for	IN
cord-015021-pol2qm74	8730	14	the	the	DT
cord-015021-pol2qm74	8730	15	hypermstabolic	hypermstabolic	NN
cord-015021-pol2qm74	8730	16	burn	burn	VB
cord-015021-pol2qm74	8730	17	patient	patient	JJ
cord-015021-pol2qm74	8730	18	.	.	.
cord-015021-pol2qm74	8731	1	These	these	DT
cord-015021-pol2qm74	8731	2	advances	advance	NNS
cord-015021-pol2qm74	8731	3	have	have	VBP
cord-015021-pol2qm74	8731	4	markedly	markedly	RB
cord-015021-pol2qm74	8731	5	increaesd	increaesd	JJ
cord-015021-pol2qm74	8731	6	survival	survival	NN
cord-015021-pol2qm74	8731	7	rates	rate	NNS
cord-015021-pol2qm74	8731	8	for	for	IN
cord-015021-pol2qm74	8731	9	given	give	VBN
cord-015021-pol2qm74	8731	10	burn	burn	NN
cord-015021-pol2qm74	8731	11	mimes	mime	NNS
cord-015021-pol2qm74	8731	12	,	,	,
cord-015021-pol2qm74	8731	13	s	s	NNP
cord-015021-pol2qm74	8731	14	~	~	NNP
cord-015021-pol2qm74	8731	15	ch	ch	NN
cord-015021-pol2qm74	8731	16	that	that	WDT
cord-015021-pol2qm74	8731	17	burns	burns	NNP
cord-015021-pol2qm74	8731	18	which	which	WDT
cord-015021-pol2qm74	8731	19	would	would	MD
cord-015021-pol2qm74	8731	20	previously	previously	RB
cord-015021-pol2qm74	8731	21	have	have	VB
cord-015021-pol2qm74	8731	22	been	be	VBN
cord-015021-pol2qm74	8731	23	considered	consider	VBN
cord-015021-pol2qm74	8731	24	to	to	TO
cord-015021-pol2qm74	8731	25	be	be	VB
cord-015021-pol2qm74	8731	26	aniformly	aniformly	JJ
cord-015021-pol2qm74	8731	27	fetal	fetal	JJ
cord-015021-pol2qm74	8731	28	,	,	,
cord-015021-pol2qm74	8731	29	are	be	VBP
cord-015021-pol2qm74	8731	30	now	now	RB
cord-015021-pol2qm74	8731	31	readily	readily	RB
cord-015021-pol2qm74	8731	32	survivable	survivable	JJ
cord-015021-pol2qm74	8731	33	.	.	.
cord-015021-pol2qm74	8732	1	Thsre	Thsre	NNP
cord-015021-pol2qm74	8732	2	remain	remain	VBP
cord-015021-pol2qm74	8732	3	two	two	CD
cord-015021-pol2qm74	8732	4	unsolved	unsolved	JJ
cord-015021-pol2qm74	8732	5	problems	problem	NNS
cord-015021-pol2qm74	8732	6	in	in	IN
cord-015021-pol2qm74	8732	7	burn	burn	NN
cord-015021-pol2qm74	8732	8	care	care	NN
cord-015021-pol2qm74	8732	9	,	,	,
cord-015021-pol2qm74	8732	10	which	which	WDT
cord-015021-pol2qm74	8732	11	are	be	VBP
cord-015021-pol2qm74	8732	12	limiting	limit	VBG
cord-015021-pol2qm74	8732	13	survivability	survivability	NN
cord-015021-pol2qm74	8732	14	cf	cf	RB
cord-015021-pol2qm74	8732	15	burn	burn	NN
cord-015021-pol2qm74	8732	16	patients	patient	NNS
cord-015021-pol2qm74	8732	17	.	.	.
cord-015021-pol2qm74	8733	1	The	the	DT
cord-015021-pol2qm74	8733	2	first	first	JJ
cord-015021-pol2qm74	8733	3	ie	ie	FW
cord-015021-pol2qm74	8733	4	ths	ths	NN
cord-015021-pol2qm74	8733	5	treatment	treatment	NN
cord-015021-pol2qm74	8733	6	of	of	IN
cord-015021-pol2qm74	8733	7	inhalation	inhalation	NN
cord-015021-pol2qm74	8733	8	injury	injury	NN
cord-015021-pol2qm74	8733	9	.	.	.
cord-015021-pol2qm74	8734	1	Ths	ths	NN
cord-015021-pol2qm74	8734	2	sscond	sscond	NN
cord-015021-pol2qm74	8734	3	is	be	VBZ
cord-015021-pol2qm74	8734	4	how	how	WRB
cord-015021-pol2qm74	8734	5	to	to	TO
cord-015021-pol2qm74	8734	6	obtain	obtain	VB
cord-015021-pol2qm74	8734	7	Coverage	coverage	NN
cord-015021-pol2qm74	8734	8	of	of	IN
cord-015021-pol2qm74	8734	9	ths	ths	NNP
cord-015021-pol2qm74	8734	10	maaaivsly	maaaivsly	NN
cord-015021-pol2qm74	8734	11	burned	burn	VBD
cord-015021-pol2qm74	8734	12	patient	patient	NN
cord-015021-pol2qm74	8734	13	,	,	,
cord-015021-pol2qm74	8734	14	who	who	WP
cord-015021-pol2qm74	8734	15	has	have	VBZ
cord-015021-pol2qm74	8734	16	limited	limit	VBN
cord-015021-pol2qm74	8734	17	skin	skin	NN
cord-015021-pol2qm74	8734	18	graft	graft	NN
cord-015021-pol2qm74	8734	19	donor	donor	NN
cord-015021-pol2qm74	8734	20	sites	site	NNS
cord-015021-pol2qm74	8734	21	available	available	JJ
cord-015021-pol2qm74	8734	22	.	.	.
cord-015021-pol2qm74	8735	1	This	this	DT
cord-015021-pol2qm74	8735	2	ssssion	ssssion	NN
cord-015021-pol2qm74	8735	3	will	will	MD
cord-015021-pol2qm74	8735	4	focus	focus	VB
cord-015021-pol2qm74	8735	5	on	on	IN
cord-015021-pol2qm74	8735	6	the	the	DT
cord-015021-pol2qm74	8735	7	new	new	JJ
cord-015021-pol2qm74	8735	8	treatments	treatment	NNS
cord-015021-pol2qm74	8735	9	being	be	VBG
cord-015021-pol2qm74	8735	10	developed	develop	VBN
cord-015021-pol2qm74	8735	11	to	to	TO
cord-015021-pol2qm74	8735	12	obtain	obtain	VB
cord-015021-pol2qm74	8735	13	permanent	permanent	JJ
cord-015021-pol2qm74	8735	14	coverage	coverage	NN
cord-015021-pol2qm74	8735	15	of	of	IN
cord-015021-pol2qm74	8735	16	burn	burn	NN
cord-015021-pol2qm74	8735	17	wounds	wound	NNS
cord-015021-pol2qm74	8735	18	.	.	.
cord-015021-pol2qm74	8736	1	These	these	DT
cord-015021-pol2qm74	8736	2	include	include	VBP
cord-015021-pol2qm74	8736	3	the	the	DT
cord-015021-pol2qm74	8736	4	use	use	NN
cord-015021-pol2qm74	8736	5	of	of	IN
cord-015021-pol2qm74	8736	6	various	various	JJ
cord-015021-pol2qm74	8736	7	tcplcal	tcplcal	JJ
cord-015021-pol2qm74	8736	8	growth	growth	NN
cord-015021-pol2qm74	8736	9	£	£	NN
cord-015021-pol2qm74	8736	10	aotore	aotore	NN
cord-015021-pol2qm74	8736	11	which	which	WDT
cord-015021-pol2qm74	8736	12	can	can	MD
cord-015021-pol2qm74	8736	13	Speed	speed	VB
cord-015021-pol2qm74	8736	14	the	the	DT
cord-015021-pol2qm74	8736	15	rate	rate	NN
cord-015021-pol2qm74	8736	16	of	of	IN
cord-015021-pol2qm74	8736	17	reepithelialization	reepithelialization	NN
cord-015021-pol2qm74	8736	18	of	of	IN
cord-015021-pol2qm74	8736	19	wounds	wound	NNS
cord-015021-pol2qm74	8736	20	,	,	,
cord-015021-pol2qm74	8736	21	Both	both	CC
cord-015021-pol2qm74	8736	22	the	the	DT
cord-015021-pol2qm74	8736	23	beneficial	beneficial	JJ
cord-015021-pol2qm74	8736	24	and	and	CC
cord-015021-pol2qm74	8736	25	dstrimental	dstrimental	JJ
cord-015021-pol2qm74	8736	26	effects	effect	NNS
cord-015021-pol2qm74	8736	27	of	of	IN
cord-015021-pol2qm74	8736	28	using	use	VBG
cord-015021-pol2qm74	8736	29	cultured	cultured	JJ
cord-015021-pol2qm74	8736	30	karatinooyte	karatinooyte	FW
cord-015021-pol2qm74	8736	31	preparations	preparation	NNS
cord-015021-pol2qm74	8736	32	,	,	,
cord-015021-pol2qm74	8736	33	to	to	TO
cord-015021-pol2qm74	8736	34	obtain	obtain	VB
cord-015021-pol2qm74	8736	35	in	in	IN
cord-015021-pol2qm74	8736	36	excess	excess	NN
cord-015021-pol2qm74	8736	37	of	of	IN
cord-015021-pol2qm74	8736	38	one	one	CD
cord-015021-pol2qm74	8736	39	squats	squat	NNS
cord-015021-pol2qm74	8736	40	meter	meter	NN
cord-015021-pol2qm74	8736	41	of	of	IN
cord-015021-pol2qm74	8736	42	a	a	DT
cord-015021-pol2qm74	8736	43	pseudoskin	pseudoskin	FW
cord-015021-pol2qm74	8736	44	from	from	IN
cord-015021-pol2qm74	8736	45	a	a	DT
cord-015021-pol2qm74	8736	46	single	single	JJ
cord-015021-pol2qm74	8736	47	fifteen	fifteen	CD
cord-015021-pol2qm74	8736	48	square	square	JJ
cord-015021-pol2qm74	8736	49	centimeter	centimeter	NN
cord-015021-pol2qm74	8736	50	biopsy	biopsy	NN
cord-015021-pol2qm74	8736	51	of	of	IN
cord-015021-pol2qm74	8736	52	unburned	unburned	JJ
cord-015021-pol2qm74	8736	53	skin	skin	NN
cord-015021-pol2qm74	8736	54	,	,	,
cord-015021-pol2qm74	8736	55	will	will	MD
cord-015021-pol2qm74	8736	56	be	be	VB
cord-015021-pol2qm74	8736	57	discussed	discuss	VBN
cord-015021-pol2qm74	8736	58	,	,	,
cord-015021-pol2qm74	8736	59	Finally	finally	RB
cord-015021-pol2qm74	8736	60	,	,	,
cord-015021-pol2qm74	8736	61	the	the	DT
cord-015021-pol2qm74	8736	62	used	use	VBN
cord-015021-pol2qm74	8736	63	for	for	IN
cord-015021-pol2qm74	8736	64	artificlal	artificlal	JJ
cord-015021-pol2qm74	8736	65	dermal	dermal	JJ
cord-015021-pol2qm74	8736	66	preparations	preparation	NNS
cord-015021-pol2qm74	8736	67	will	will	MD
cord-015021-pol2qm74	8736	68	be	be	VB
cord-015021-pol2qm74	8736	69	discussed	discuss	VBN
cord-015021-pol2qm74	8736	70	.	.	.
cord-015021-pol2qm74	8737	1	integumentary	integumentary	JJ
cord-015021-pol2qm74	8737	2	wound	wound	NN
cord-015021-pol2qm74	8737	3	healing	healing	NN
cord-015021-pol2qm74	8737	4	consists	consist	NNS
cord-015021-pol2qm74	8737	5	of	of	IN
cord-015021-pol2qm74	8737	6	simultaneous	simultaneous	JJ
cord-015021-pol2qm74	8737	7	epithelializalion	epithelializalion	NN
cord-015021-pol2qm74	8737	8	and	and	CC
cord-015021-pol2qm74	8737	9	contraction	contraction	NN
cord-015021-pol2qm74	8737	10	.	.	.
cord-015021-pol2qm74	8738	1	Not	not	RB
cord-015021-pol2qm74	8738	2	long	long	RB
cord-015021-pol2qm74	8738	3	ago	ago	RB
cord-015021-pol2qm74	8738	4	,	,	,
cord-015021-pol2qm74	8738	5	it	-PRON-	PRP
cord-015021-pol2qm74	8738	6	was	be	VBD
cord-015021-pol2qm74	8738	7	thought	think	VBN
cord-015021-pol2qm74	8738	8	that	that	IN
cord-015021-pol2qm74	8738	9	healing	healing	NN
cord-015021-pol2qm74	8738	10	proceeds	proceed	NNS
cord-015021-pol2qm74	8738	11	at	at	IN
cord-015021-pol2qm74	8738	12	an	an	DT
cord-015021-pol2qm74	8738	13	optimum	optimum	JJ
cord-015021-pol2qm74	8738	14	fixed	fix	VBN
cord-015021-pol2qm74	8738	15	rate	rate	NN
cord-015021-pol2qm74	8738	16	and	and	CC
cord-015021-pol2qm74	8738	17	could	could	MD
cord-015021-pol2qm74	8738	18	only	only	RB
cord-015021-pol2qm74	8738	19	be	be	VB
cord-015021-pol2qm74	8738	20	delayed	delay	VBN
cord-015021-pol2qm74	8738	21	.	.	.
cord-015021-pol2qm74	8739	1	The	the	DT
cord-015021-pol2qm74	8739	2	recent	recent	JJ
cord-015021-pol2qm74	8739	3	explosion	explosion	NN
cord-015021-pol2qm74	8739	4	in	in	IN
cord-015021-pol2qm74	8739	5	molecular	molecular	JJ
cord-015021-pol2qm74	8739	6	biology	biology	NN
cord-015021-pol2qm74	8739	7	and	and	CC
cord-015021-pol2qm74	8739	8	recombinant	recombinant	JJ
cord-015021-pol2qm74	8739	9	gene	gene	NN
cord-015021-pol2qm74	8739	10	techniques	technique	NNS
cord-015021-pol2qm74	8739	11	have	have	VBP
cord-015021-pol2qm74	8739	12	produced	produce	VBN
cord-015021-pol2qm74	8739	13	information	information	NN
cord-015021-pol2qm74	8739	14	on	on	IN
cord-015021-pol2qm74	8739	15	the	the	DT
cord-015021-pol2qm74	8739	16	biological	biological	JJ
cord-015021-pol2qm74	8739	17	activity	activity	NN
cord-015021-pol2qm74	8739	18	of	of	IN
cord-015021-pol2qm74	8739	19	compounds	compound	NNS
cord-015021-pol2qm74	8739	20	previously	previously	RB
cord-015021-pol2qm74	8739	21	believed	believe	VBD
cord-015021-pol2qm74	8739	22	to	to	TO
cord-015021-pol2qm74	8739	23	be	be	VB
cord-015021-pol2qm74	8739	24	biologically	biologically	RB
cord-015021-pol2qm74	8739	25	inert	inert	JJ
cord-015021-pol2qm74	8739	26	.	.	.
cord-015021-pol2qm74	8740	1	Many	many	JJ
cord-015021-pol2qm74	8740	2	current	current	JJ
cord-015021-pol2qm74	8740	3	attempts	attempt	NNS
cord-015021-pol2qm74	8740	4	to	to	TO
cord-015021-pol2qm74	8740	5	modulate	modulate	VB
cord-015021-pol2qm74	8740	6	the	the	DT
cord-015021-pol2qm74	8740	7	rate	rate	NN
cord-015021-pol2qm74	8740	8	of	of	IN
cord-015021-pol2qm74	8740	9	wound	wound	NN
cord-015021-pol2qm74	8740	10	healing	healing	NN
cord-015021-pol2qm74	8740	11	center	center	NN
cord-015021-pol2qm74	8740	12	on	on	IN
cord-015021-pol2qm74	8740	13	the	the	DT
cord-015021-pol2qm74	8740	14	topical	topical	JJ
cord-015021-pol2qm74	8740	15	application	application	NN
cord-015021-pol2qm74	8740	16	of	of	IN
cord-015021-pol2qm74	8740	17	various	various	JJ
cord-015021-pol2qm74	8740	18	growth	growth	NN
cord-015021-pol2qm74	8740	19	factors	factor	NNS
cord-015021-pol2qm74	8740	20	produced	produce	VBN
cord-015021-pol2qm74	8740	21	by	by	IN
cord-015021-pol2qm74	8740	22	integumentary	integumentary	JJ
cord-015021-pol2qm74	8740	23	cells	cell	NNS
cord-015021-pol2qm74	8740	24	or	or	CC
cord-015021-pol2qm74	8740	25	agents	agent	NNS
cord-015021-pol2qm74	8740	26	designed	design	VBN
cord-015021-pol2qm74	8740	27	to	to	TO
cord-015021-pol2qm74	8740	28	modulate	modulate	VB
cord-015021-pol2qm74	8740	29	growth	growth	NN
cord-015021-pol2qm74	8740	30	factor	factor	NN
cord-015021-pol2qm74	8740	31	expression	expression	NN
cord-015021-pol2qm74	8740	32	or	or	CC
cord-015021-pol2qm74	8740	33	response	response	NN
cord-015021-pol2qm74	8740	34	.	.	.
cord-015021-pol2qm74	8741	1	Epidermal	epidermal	JJ
cord-015021-pol2qm74	8741	2	growth	growth	NN
cord-015021-pol2qm74	8741	3	factor	factor	NN
cord-015021-pol2qm74	8741	4	(	(	-LRB-
cord-015021-pol2qm74	8741	5	EGF	EGF	NNP
cord-015021-pol2qm74	8741	6	)	)	-RRB-
cord-015021-pol2qm74	8741	7	,	,	,
cord-015021-pol2qm74	8741	8	plateiet	plateiet	NNP
cord-015021-pol2qm74	8741	9	derived	derive	VBD
cord-015021-pol2qm74	8741	10	growth	growth	NN
cord-015021-pol2qm74	8741	11	factor	factor	NN
cord-015021-pol2qm74	8741	12	(	(	-LRB-
cord-015021-pol2qm74	8741	13	PDGF	PDGF	NNP
cord-015021-pol2qm74	8741	14	)	)	-RRB-
cord-015021-pol2qm74	8741	15	,	,	,
cord-015021-pol2qm74	8741	16	transforming	transform	VBG
cord-015021-pol2qm74	8741	17	growth	growth	NN
cord-015021-pol2qm74	8741	18	factor	factor	NN
cord-015021-pol2qm74	8741	19	(	(	-LRB-
cord-015021-pol2qm74	8741	20	TGF	TGF	NNP
cord-015021-pol2qm74	8741	21	)	)	-RRB-
cord-015021-pol2qm74	8741	22	and	and	CC
cord-015021-pol2qm74	8741	23	fibroblast	fibroblast	NN
cord-015021-pol2qm74	8741	24	growth	growth	NN
cord-015021-pol2qm74	8741	25	factor	factor	NN
cord-015021-pol2qm74	8741	26	(	(	-LRB-
cord-015021-pol2qm74	8741	27	FGF	FGF	NNP
cord-015021-pol2qm74	8741	28	)	)	-RRB-
cord-015021-pol2qm74	8741	29	have	have	VBP
cord-015021-pol2qm74	8741	30	been	be	VBN
cord-015021-pol2qm74	8741	31	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	8741	32	,	,	,
cord-015021-pol2qm74	8741	33	both	both	DT
cord-015021-pol2qm74	8741	34	in	in	IN
cord-015021-pol2qm74	8741	35	vitro	vitro	FW
cord-015021-pol2qm74	8741	36	and	and	CC
cord-015021-pol2qm74	8741	37	in	in	IN
cord-015021-pol2qm74	8741	38	vivo	vivo	NN
cord-015021-pol2qm74	8741	39	,	,	,
cord-015021-pol2qm74	8741	40	to	to	TO
cord-015021-pol2qm74	8741	41	stimulate	stimulate	VB
cord-015021-pol2qm74	8741	42	the	the	DT
cord-015021-pol2qm74	8741	43	proliferation	proliferation	NN
cord-015021-pol2qm74	8741	44	and	and	CC
cord-015021-pol2qm74	8741	45	diferentiation	diferentiation	NN
cord-015021-pol2qm74	8741	46	of	of	IN
cord-015021-pol2qm74	8741	47	their	-PRON-	PRP$
cord-015021-pol2qm74	8741	48	designated	designate	VBN
cord-015021-pol2qm74	8741	49	cells	cell	NNS
cord-015021-pol2qm74	8741	50	types	type	NNS
cord-015021-pol2qm74	8741	51	.	.	.
cord-015021-pol2qm74	8742	1	EGF	EGF	NNP
cord-015021-pol2qm74	8742	2	and	and	CC
cord-015021-pol2qm74	8742	3	PDGF	PDGF	NNP
cord-015021-pol2qm74	8742	4	have	have	VBP
cord-015021-pol2qm74	8742	5	been	be	VBN
cord-015021-pol2qm74	8742	6	clearly	clearly	RB
cord-015021-pol2qm74	8742	7	demonstraled	demonstrale	VBN
cord-015021-pol2qm74	8742	8	to	to	TO
cord-015021-pol2qm74	8742	9	increase	increase	VB
cord-015021-pol2qm74	8742	10	the	the	DT
cord-015021-pol2qm74	8742	11	rate	rate	NN
cord-015021-pol2qm74	8742	12	of	of	IN
cord-015021-pol2qm74	8742	13	wound	wound	NN
cord-015021-pol2qm74	8742	14	closure	closure	NN
cord-015021-pol2qm74	8742	15	in	in	IN
cord-015021-pol2qm74	8742	16	partial	partial	JJ
cord-015021-pol2qm74	8742	17	and	and	CC
cord-015021-pol2qm74	8742	18	full	full	JJ
cord-015021-pol2qm74	8742	19	thickness	thickness	NN
cord-015021-pol2qm74	8742	20	wounds	wound	NNS
cord-015021-pol2qm74	8742	21	.	.	.
cord-015021-pol2qm74	8743	1	PDGF	PDGF	NNP
cord-015021-pol2qm74	8743	2	also	also	RB
cord-015021-pol2qm74	8743	3	has	have	VBZ
cord-015021-pol2qm74	8743	4	demonstrated	demonstrate	VBN
cord-015021-pol2qm74	8743	5	efficacy	efficacy	NN
cord-015021-pol2qm74	8743	6	in	in	IN
cord-015021-pol2qm74	8743	7	the	the	DT
cord-015021-pol2qm74	8743	8	closure	closure	NN
cord-015021-pol2qm74	8743	9	of	of	IN
cord-015021-pol2qm74	8743	10	recalcitrant	recalcitrant	JJ
cord-015021-pol2qm74	8743	11	pressure	pressure	NN
cord-015021-pol2qm74	8743	12	sores	sore	NNS
cord-015021-pol2qm74	8743	13	,	,	,
cord-015021-pol2qm74	8743	14	whereas	whereas	IN
cord-015021-pol2qm74	8743	15	TGF	TGF	NNP
cord-015021-pol2qm74	8743	16	increases	increase	VBZ
cord-015021-pol2qm74	8743	17	the	the	DT
cord-015021-pol2qm74	8743	18	tensile	tensile	JJ
cord-015021-pol2qm74	8743	19	strength	strength	NN
cord-015021-pol2qm74	8743	20	of	of	IN
cord-015021-pol2qm74	8743	21	incisiona	incisiona	NNP
cord-015021-pol2qm74	8743	22	[	[	-LRB-
cord-015021-pol2qm74	8743	23	wounds	wound	NNS
cord-015021-pol2qm74	8743	24	and	and	CC
cord-015021-pol2qm74	8743	25	FGF	FGF	NNP
cord-015021-pol2qm74	8743	26	stimulates	stimulate	VBZ
cord-015021-pol2qm74	8743	27	angiogenesis	angiogenesis	NN
cord-015021-pol2qm74	8743	28	.	.	.
cord-015021-pol2qm74	8744	1	It	-PRON-	PRP
cord-015021-pol2qm74	8744	2	appears	appear	VBZ
cord-015021-pol2qm74	8744	3	that	that	IN
cord-015021-pol2qm74	8744	4	epidermal	epidermal	JJ
cord-015021-pol2qm74	8744	5	keratinocyte	keratinocyte	JJ
cord-015021-pol2qm74	8744	6	migration	migration	NN
cord-015021-pol2qm74	8744	7	during	during	IN
cord-015021-pol2qm74	8744	8	wound	wound	NN
cord-015021-pol2qm74	8744	9	healing	healing	NN
cord-015021-pol2qm74	8744	10	depends	depend	VBZ
cord-015021-pol2qm74	8744	11	on	on	IN
cord-015021-pol2qm74	8744	12	integrin	integrin	NN
cord-015021-pol2qm74	8744	13	-	-	HYPH
cord-015021-pol2qm74	8744	14	mediated	mediate	VBN
cord-015021-pol2qm74	8744	15	interactions	interaction	NNS
cord-015021-pol2qm74	8744	16	with	with	IN
cord-015021-pol2qm74	8744	17	compounds	compound	NNS
cord-015021-pol2qm74	8744	18	and	and	CC
cord-015021-pol2qm74	8744	19	ceils	ceils	NNP
cord-015021-pol2qm74	8744	20	extracellular	extracellular	JJ
cord-015021-pol2qm74	8744	21	matrix	matrix	NN
cord-015021-pol2qm74	8744	22	.	.	.
cord-015021-pol2qm74	8745	1	Additionally	additionally	RB
cord-015021-pol2qm74	8745	2	,	,	,
cord-015021-pol2qm74	8745	3	the	the	DT
cord-015021-pol2qm74	8745	4	activities	activity	NNS
cord-015021-pol2qm74	8745	5	of	of	IN
cord-015021-pol2qm74	8745	6	extracellular	extracellular	JJ
cord-015021-pol2qm74	8745	7	glycoproteins	glycoprotein	NNS
cord-015021-pol2qm74	8745	8	such	such	JJ
cord-015021-pol2qm74	8745	9	as	as	IN
cord-015021-pol2qm74	8745	10	fibronectin	fibronectin	NN
cord-015021-pol2qm74	8745	11	,	,	,
cord-015021-pol2qm74	8745	12	fibrinogen	fibrinogen	NN
cord-015021-pol2qm74	8745	13	,	,	,
cord-015021-pol2qm74	8745	14	laminin	laminin	NN
cord-015021-pol2qm74	8745	15	and	and	CC
cord-015021-pol2qm74	8745	16	thrombospondin	thrombospondin	NNP
cord-015021-pol2qm74	8745	17	are	be	VBP
cord-015021-pol2qm74	8745	18	coordinated	coordinate	VBN
cord-015021-pol2qm74	8745	19	by	by	IN
cord-015021-pol2qm74	8745	20	multiple	multiple	JJ
cord-015021-pol2qm74	8745	21	integrins	integrin	NNS
cord-015021-pol2qm74	8745	22	with	with	IN
cord-015021-pol2qm74	8745	23	specific	specific	JJ
cord-015021-pol2qm74	8745	24	distributions	distribution	NNS
cord-015021-pol2qm74	8745	25	and	and	CC
cord-015021-pol2qm74	8745	26	binding	bind	VBG
cord-015021-pol2qm74	8745	27	affinities	affinity	NNS
cord-015021-pol2qm74	8745	28	.	.	.
cord-015021-pol2qm74	8746	1	Currently	currently	RB
cord-015021-pol2qm74	8746	2	,	,	,
cord-015021-pol2qm74	8746	3	agents	agent	NNS
cord-015021-pol2qm74	8746	4	which	which	WDT
cord-015021-pol2qm74	8746	5	incorporate	incorporate	VBP
cord-015021-pol2qm74	8746	6	specific	specific	JJ
cord-015021-pol2qm74	8746	7	protein	protein	NN
cord-015021-pol2qm74	8746	8	sequences	sequence	NNS
cord-015021-pol2qm74	8746	9	essential	essential	JJ
cord-015021-pol2qm74	8746	10	for	for	IN
cord-015021-pol2qm74	8746	11	the	the	DT
cord-015021-pol2qm74	8746	12	interaction	interaction	NN
cord-015021-pol2qm74	8746	13	of	of	IN
cord-015021-pol2qm74	8746	14	the	the	DT
cord-015021-pol2qm74	8746	15	glycoproteins	glycoprotein	NNS
cord-015021-pol2qm74	8746	16	with	with	IN
cord-015021-pol2qm74	8746	17	the	the	DT
cord-015021-pol2qm74	8746	18	cells	cell	NNS
cord-015021-pol2qm74	8746	19	of	of	IN
cord-015021-pol2qm74	8746	20	the	the	DT
cord-015021-pol2qm74	8746	21	extracellular	extracellular	JJ
cord-015021-pol2qm74	8746	22	matrix	matrix	NN
cord-015021-pol2qm74	8746	23	are	be	VBP
cord-015021-pol2qm74	8746	24	being	be	VBG
cord-015021-pol2qm74	8746	25	investigated	investigate	VBN
cord-015021-pol2qm74	8746	26	.	.	.
cord-015021-pol2qm74	8747	1	It	-PRON-	PRP
cord-015021-pol2qm74	8747	2	is	be	VBZ
cord-015021-pol2qm74	8747	3	has	have	VBZ
cord-015021-pol2qm74	8747	4	been	be	VBN
cord-015021-pol2qm74	8747	5	clearly	clearly	RB
cord-015021-pol2qm74	8747	6	established	establish	VBN
cord-015021-pol2qm74	8747	7	that	that	IN
cord-015021-pol2qm74	8747	8	the	the	DT
cord-015021-pol2qm74	8747	9	rate	rate	NN
cord-015021-pol2qm74	8747	10	and	and	CC
cord-015021-pol2qm74	8747	11	nature	nature	NN
cord-015021-pol2qm74	8747	12	of	of	IN
cord-015021-pol2qm74	8747	13	wound	wound	NN
cord-015021-pol2qm74	8747	14	healing	healing	NN
cord-015021-pol2qm74	8747	15	can	can	MD
cord-015021-pol2qm74	8747	16	be	be	VB
cord-015021-pol2qm74	8747	17	influenced	influence	VBN
cord-015021-pol2qm74	8747	18	by	by	IN
cord-015021-pol2qm74	8747	19	the	the	DT
cord-015021-pol2qm74	8747	20	application	application	NN
cord-015021-pol2qm74	8747	21	of	of	IN
cord-015021-pol2qm74	8747	22	various	various	JJ
cord-015021-pol2qm74	8747	23	agents	agent	NNS
cord-015021-pol2qm74	8747	24	and	and	CC
cord-015021-pol2qm74	8747	25	that	that	IN
cord-015021-pol2qm74	8747	26	sufficient	sufficient	JJ
cord-015021-pol2qm74	8747	27	quantities	quantity	NNS
cord-015021-pol2qm74	8747	28	of	of	IN
cord-015021-pol2qm74	8747	29	these	these	DT
cord-015021-pol2qm74	8747	30	agents	agent	NNS
cord-015021-pol2qm74	8747	31	can	can	MD
cord-015021-pol2qm74	8747	32	be	be	VB
cord-015021-pol2qm74	8747	33	manufactured	manufacture	VBN
cord-015021-pol2qm74	8747	34	.	.	.
cord-015021-pol2qm74	8748	1	The	the	DT
cord-015021-pol2qm74	8748	2	future	future	JJ
cord-015021-pol2qm74	8748	3	challenge	challenge	NN
cord-015021-pol2qm74	8748	4	is	be	VBZ
cord-015021-pol2qm74	8748	5	to	to	TO
cord-015021-pol2qm74	8748	6	develop	develop	VB
cord-015021-pol2qm74	8748	7	techniques	technique	NNS
cord-015021-pol2qm74	8748	8	to	to	IN
cord-015021-pol2qm74	8748	9	Now	now	RB
cord-015021-pol2qm74	8748	10	the	the	DT
cord-015021-pol2qm74	8748	11	objective	objective	JJ
cord-015021-pol2qm74	8748	12	evaluation	evaluation	NN
cord-015021-pol2qm74	8748	13	of	of	IN
cord-015021-pol2qm74	8748	14	the	the	DT
cord-015021-pol2qm74	8748	15	clinical	clinical	JJ
cord-015021-pol2qm74	8748	16	efficacy	efficacy	NN
cord-015021-pol2qm74	8748	17	of	of	IN
cord-015021-pol2qm74	8748	18	these	these	DT
cord-015021-pol2qm74	8748	19	various	various	JJ
cord-015021-pol2qm74	8748	20	agents	agent	NNS
cord-015021-pol2qm74	8748	21	and	and	CC
cord-015021-pol2qm74	8748	22	to	to	TO
cord-015021-pol2qm74	8748	23	employ	employ	VB
cord-015021-pol2qm74	8748	24	the	the	DT
cord-015021-pol2qm74	8748	25	appropriate	appropriate	JJ
cord-015021-pol2qm74	8748	26	agents	agent	NNS
cord-015021-pol2qm74	8748	27	in	in	IN
cord-015021-pol2qm74	8748	28	a	a	DT
cord-015021-pol2qm74	8748	29	cost	cost	NN
cord-015021-pol2qm74	8748	30	-	-	HYPH
cord-015021-pol2qm74	8748	31	effective	effective	JJ
cord-015021-pol2qm74	8748	32	manner	manner	NN
cord-015021-pol2qm74	8748	33	.	.	.
cord-015021-pol2qm74	8748	34	 	 	_SP
cord-015021-pol2qm74	8749	1	transplantation	transplantation	NN
cord-015021-pol2qm74	8749	2	;	;	:
cord-015021-pol2qm74	8749	3	and	and	CC
cord-015021-pol2qm74	8749	4	4	4	LS
cord-015021-pol2qm74	8749	5	)	)	-RRB-
cord-015021-pol2qm74	8749	6	the	the	DT
cord-015021-pol2qm74	8749	7	immune	immune	JJ
cord-015021-pol2qm74	8749	8	status	status	NN
cord-015021-pol2qm74	8749	9	/	/	SYM
cord-015021-pol2qm74	8749	10	manipulation	manipulation	NN
cord-015021-pol2qm74	8749	11	of	of	IN
cord-015021-pol2qm74	8749	12	the	the	DT
cord-015021-pol2qm74	8749	13	host	host	NN
cord-015021-pol2qm74	8749	14	.	.	.
cord-015021-pol2qm74	8750	1	Multiple	multiple	JJ
cord-015021-pol2qm74	8750	2	interactive	interactive	JJ
cord-015021-pol2qm74	8750	3	variables	variable	NNS
cord-015021-pol2qm74	8750	4	will	will	MD
cord-015021-pol2qm74	8750	5	determine	determine	VB
cord-015021-pol2qm74	8750	6	the	the	DT
cord-015021-pol2qm74	8750	7	effect	effect	NN
cord-015021-pol2qm74	8750	8	of	of	IN
cord-015021-pol2qm74	8750	9	employing	employ	VBG
cord-015021-pol2qm74	8750	10	allogeneic	allogeneic	NN
cord-015021-pol2qm74	8750	11	cells	cell	NNS
cord-015021-pol2qm74	8750	12	and	and	CC
cord-015021-pol2qm74	8750	13	tissue	tissue	NN
cord-015021-pol2qm74	8750	14	in	in	IN
cord-015021-pol2qm74	8750	15	wound	wound	NN
cord-015021-pol2qm74	8750	16	coverage	coverage	NN
cord-015021-pol2qm74	8750	17	design	design	NN
cord-015021-pol2qm74	8750	18	and	and	CC
cord-015021-pol2qm74	8750	19	a	a	DT
cord-015021-pol2qm74	8750	20	batter	batter	NN
cord-015021-pol2qm74	8750	21	understanding	understanding	NN
cord-015021-pol2qm74	8750	22	of	of	IN
cord-015021-pol2qm74	8750	23	the	the	DT
cord-015021-pol2qm74	8750	24	dynamics	dynamic	NNS
cord-015021-pol2qm74	8750	25	of	of	IN
cord-015021-pol2qm74	8750	26	the	the	DT
cord-015021-pol2qm74	8750	27	wound	wound	NN
cord-015021-pol2qm74	8750	28	-	-	HYPH
cord-015021-pol2qm74	8750	29	graft	graft	NN
cord-015021-pol2qm74	8750	30	microenvironment	microenvironment	NN
cord-015021-pol2qm74	8750	31	will	will	MD
cord-015021-pol2qm74	8750	32	facilitate	facilitate	VB
cord-015021-pol2qm74	8750	33	the	the	DT
cord-015021-pol2qm74	8750	34	dove	dove	NN
cord-015021-pol2qm74	8750	35	opment	opment	NN
cord-015021-pol2qm74	8750	36	of	of	IN
cord-015021-pol2qm74	8750	37	clinicaUy	clinicauy	JJ
cord-015021-pol2qm74	8750	38	beneficial	beneficial	JJ
cord-015021-pol2qm74	8750	39	graft	graft	NN
cord-015021-pol2qm74	8750	40	composites	composite	NNS
cord-015021-pol2qm74	8750	41	.	.	.
cord-015021-pol2qm74	8751	1	Cadaver	cadaver	NN
cord-015021-pol2qm74	8751	2	allograft	allograft	NN
cord-015021-pol2qm74	8751	3	skin	skin	NN
cord-015021-pol2qm74	8751	4	(	(	-LRB-
cord-015021-pol2qm74	8751	5	CAS	CAS	NNP
cord-015021-pol2qm74	8751	6	)	)	-RRB-
cord-015021-pol2qm74	8751	7	is	be	VBZ
cord-015021-pol2qm74	8751	8	the	the	DT
cord-015021-pol2qm74	8751	9	"	"	``
cord-015021-pol2qm74	8751	10	gold	gold	NN
cord-015021-pol2qm74	8751	11	standard	standard	NN
cord-015021-pol2qm74	8751	12	"	"	''
cord-015021-pol2qm74	8751	13	for	for	IN
cord-015021-pol2qm74	8751	14	wound	wound	JJ
cord-015021-pol2qm74	8751	15	coverage	coverage	NN
cord-015021-pol2qm74	8751	16	,	,	,
cord-015021-pol2qm74	8751	17	but	but	CC
cord-015021-pol2qm74	8751	18	has	have	VBZ
cord-015021-pol2qm74	8751	19	limitations	limitation	NNS
cord-015021-pol2qm74	8751	20	including	include	VBG
cord-015021-pol2qm74	8751	21	varied	varied	JJ
cord-015021-pol2qm74	8751	22	availability	availability	NN
cord-015021-pol2qm74	8751	23	&	&	CC
cord-015021-pol2qm74	8751	24	quality	quality	NN
cord-015021-pol2qm74	8751	25	,	,	,
cord-015021-pol2qm74	8751	26	immunogenicity	immunogenicity	IN
cord-015021-pol2qm74	8751	27	leading	lead	VBG
cord-015021-pol2qm74	8751	28	to	to	IN
cord-015021-pol2qm74	8751	29	rejection	rejection	NN
cord-015021-pol2qm74	8751	30	,	,	,
cord-015021-pol2qm74	8751	31	&	&	CC
cord-015021-pol2qm74	8751	32	potential	potential	NN
cord-015021-pol2qm74	8751	33	for	for	IN
cord-015021-pol2qm74	8751	34	disease	disease	NN
cord-015021-pol2qm74	8751	35	transmission	transmission	NN
cord-015021-pol2qm74	8751	36	.	.	.
cord-015021-pol2qm74	8752	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8752	2	development	development	NN
cord-015021-pol2qm74	8752	3	of	of	IN
cord-015021-pol2qm74	8752	4	a	a	DT
cord-015021-pol2qm74	8752	5	temporary	temporary	JJ
cord-015021-pol2qm74	8752	6	living	living	NN
cord-015021-pol2qm74	8752	7	skin	skin	NN
cord-015021-pol2qm74	8752	8	replacement	replacement	NN
cord-015021-pol2qm74	8752	9	(	(	-LRB-
cord-015021-pol2qm74	8752	10	TLSR	TLSR	NNP
cord-015021-pol2qm74	8752	11	)	)	-RRB-
cord-015021-pol2qm74	8752	12	addresses	address	VBZ
cord-015021-pol2qm74	8752	13	these	these	DT
cord-015021-pol2qm74	8752	14	issues	issue	NNS
cord-015021-pol2qm74	8752	15	;	;	:
cord-015021-pol2qm74	8752	16	the	the	DT
cord-015021-pol2qm74	8752	17	TLSR	TLSR	NNP
cord-015021-pol2qm74	8752	18	consists	consist	VBZ
cord-015021-pol2qm74	8752	19	of	of	IN
cord-015021-pol2qm74	8752	20	highly	highly	RB
cord-015021-pol2qm74	8752	21	screened	screen	VBN
cord-015021-pol2qm74	8752	22	human	human	JJ
cord-015021-pol2qm74	8752	23	neonatal	neonatal	JJ
cord-015021-pol2qm74	8752	24	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	8752	25	(	(	-LRB-
cord-015021-pol2qm74	8752	26	HF	HF	NNP
cord-015021-pol2qm74	8752	27	)	)	-RRB-
cord-015021-pol2qm74	8752	28	cultured	culture	VBN
cord-015021-pol2qm74	8752	29	in	in	IN
cord-015021-pol2qm74	8752	30	Biobrane	Biobrane	NNP
cord-015021-pol2qm74	8752	31	a	a	NNP
cord-015021-pol2qm74	8752	32	,	,	,
cord-015021-pol2qm74	8752	33	a	a	DT
cord-015021-pol2qm74	8752	34	bilayer	bilayer	NN
cord-015021-pol2qm74	8752	35	dressing	dressing	NN
cord-015021-pol2qm74	8752	36	consisting	consist	VBG
cord-015021-pol2qm74	8752	37	of	of	IN
cord-015021-pol2qm74	8752	38	nylon	nylon	NN
cord-015021-pol2qm74	8752	39	mesh	mesh	NN
cord-015021-pol2qm74	8752	40	laminated	laminate	VBN
cord-015021-pol2qm74	8752	41	to	to	IN
cord-015021-pol2qm74	8752	42	a	a	DT
cord-015021-pol2qm74	8752	43	thin	thin	JJ
cord-015021-pol2qm74	8752	44	silicone	silicone	NN
cord-015021-pol2qm74	8752	45	membrane	membrane	NN
cord-015021-pol2qm74	8752	46	which	which	WDT
cord-015021-pol2qm74	8752	47	controls	control	VBZ
cord-015021-pol2qm74	8752	48	water	water	NN
cord-015021-pol2qm74	8752	49	-	-	HYPH
cord-015021-pol2qm74	8752	50	vapor	vapor	NN
cord-015021-pol2qm74	8752	51	transmission	transmission	NN
cord-015021-pol2qm74	8752	52	.	.	.
cord-015021-pol2qm74	8753	1	Studies	study	NNS
cord-015021-pol2qm74	8753	2	in	in	IN
cord-015021-pol2qm74	8753	3	our	-PRON-	PRP$
cord-015021-pol2qm74	8753	4	lab	lab	NN
cord-015021-pol2qm74	8753	5	indicated	indicate	VBD
cord-015021-pol2qm74	8753	6	that	that	IN
cord-015021-pol2qm74	8753	7	"	"	``
cord-015021-pol2qm74	8753	8	fresW	fresW	NNP
cord-015021-pol2qm74	8753	9	~	~	NFP
cord-015021-pol2qm74	8753	10	TLSR	TLSR	NNP
cord-015021-pol2qm74	8753	11	grafts	graft	NNS
cord-015021-pol2qm74	8753	12	reproducibly	reproducibly	RB
cord-015021-pol2qm74	8753	13	close	close	VBP
cord-015021-pol2qm74	8753	14	full	full	JJ
cord-015021-pol2qm74	8753	15	-	-	HYPH
cord-015021-pol2qm74	8753	16	thickness	thickness	NN
cord-015021-pol2qm74	8753	17	wounds	wound	NNS
cord-015021-pol2qm74	8753	18	in	in	IN
cord-015021-pol2qm74	8753	19	mice	mouse	NNS
cord-015021-pol2qm74	8753	20	&	&	CC
cord-015021-pol2qm74	8753	21	perform	perform	VB
cord-015021-pol2qm74	8753	22	better	well	JJR
cord-015021-pol2qm74	8753	23	than	than	IN
cord-015021-pol2qm74	8753	24	BB	BB	NNP
cord-015021-pol2qm74	8753	25	controls	control	NNS
cord-015021-pol2qm74	8753	26	.	.	.
cord-015021-pol2qm74	8754	1	We	-PRON-	PRP
cord-015021-pol2qm74	8754	2	studied	study	VBD
cord-015021-pol2qm74	8754	3	wound	wound	JJ
cord-015021-pol2qm74	8754	4	adherence	adherence	NN
cord-015021-pol2qm74	8754	5	&	&	CC
cord-015021-pol2qm74	8754	6	structural	structural	JJ
cord-015021-pol2qm74	8754	7	/	/	SYM
cord-015021-pol2qm74	8754	8	molecular	molecular	JJ
cord-015021-pol2qm74	8754	9	properties	property	NNS
cord-015021-pol2qm74	8754	10	of	of	IN
cord-015021-pol2qm74	8754	11	fresh	fresh	JJ
cord-015021-pol2qm74	8754	12	&	&	CC
cord-015021-pol2qm74	8754	13	cryopreserved	cryopreserved	JJ
cord-015021-pol2qm74	8754	14	(	(	-LRB-
cord-015021-pol2qm74	8754	15	CRYO	CRYO	NNP
cord-015021-pol2qm74	8754	16	)	)	-RRB-
cord-015021-pol2qm74	8755	1	TLSR	TLSR	NNP
cord-015021-pol2qm74	8755	2	.	.	.
cord-015021-pol2qm74	8756	1	METHODS	methods	NN
cord-015021-pol2qm74	8756	2	:	:	:
cord-015021-pol2qm74	8757	1	TLSRs	tlsr	NNS
cord-015021-pol2qm74	8757	2	were	be	VBD
cord-015021-pol2qm74	8757	3	prepared	prepare	VBN
cord-015021-pol2qm74	8757	4	by	by	IN
cord-015021-pol2qm74	8757	5	seeding	seed	VBG
cord-015021-pol2qm74	8757	6	4000	4000	CD
cord-015021-pol2qm74	8757	7	/	/	SYM
cord-015021-pol2qm74	8757	8	co	co	NN
cord-015021-pol2qm74	8757	9	2	2	CD
cord-015021-pol2qm74	8757	10	HF	HF	NNP
cord-015021-pol2qm74	8757	11	in	in	IN
cord-015021-pol2qm74	8757	12	BB	bb	NN
cord-015021-pol2qm74	8757	13	nylon	nylon	NN
cord-015021-pol2qm74	8757	14	mesh	mesh	NN
cord-015021-pol2qm74	8757	15	in	in	IN
cord-015021-pol2qm74	8757	16	DMEM	DMEM	NNP
cord-015021-pol2qm74	8757	17	.	.	.
cord-015021-pol2qm74	8758	1	HF	HF	NNP
cord-015021-pol2qm74	8758	2	quickly	quickly	RB
cord-015021-pol2qm74	8758	3	attached	attach	VBD
cord-015021-pol2qm74	8758	4	to	to	IN
cord-015021-pol2qm74	8758	5	the	the	DT
cord-015021-pol2qm74	8758	6	nylon	nylon	NN
cord-015021-pol2qm74	8758	7	mesh	mesh	NN
cord-015021-pol2qm74	8758	8	&	&	CC
cord-015021-pol2qm74	8758	9	were	be	VBD
cord-015021-pol2qm74	8758	10	allowed	allow	VBN
cord-015021-pol2qm74	8758	11	to	to	TO
cord-015021-pol2qm74	8758	12	proliferate	proliferate	VB
cord-015021-pol2qm74	8758	13	3	3	CD
cord-015021-pol2qm74	8758	14	-	-	SYM
cord-015021-pol2qm74	8758	15	6	6	CD
cord-015021-pol2qm74	8758	16	wks	wks	NN
cord-015021-pol2qm74	8758	17	.	.	.
cord-015021-pol2qm74	8759	1	Fibroblast	fibroblast	JJ
cord-015021-pol2qm74	8759	2	mitochondrial	mitochondrial	NN
cord-015021-pol2qm74	8759	3	activity	activity	NN
cord-015021-pol2qm74	8759	4	was	be	VBD
cord-015021-pol2qm74	8759	5	assayed	assay	VBN
cord-015021-pol2qm74	8759	6	by	by	IN
cord-015021-pol2qm74	8759	7	MTT	MTT	NNP
cord-015021-pol2qm74	8759	8	assay	assay	NN
cord-015021-pol2qm74	8759	9	.	.	.
cord-015021-pol2qm74	8760	1	Matrix	matrix	NN
cord-015021-pol2qm74	8760	2	proteins	protein	NNS
cord-015021-pol2qm74	8760	3	were	be	VBD
cord-015021-pol2qm74	8760	4	identified	identify	VBN
cord-015021-pol2qm74	8760	5	by	by	IN
cord-015021-pol2qm74	8760	6	immunostaining	immunostaine	VBG
cord-015021-pol2qm74	8760	7	,	,	,
cord-015021-pol2qm74	8760	8	mRNAs	mRNAs	NNPS
cord-015021-pol2qm74	8760	9	for	for	IN
cord-015021-pol2qm74	8760	10	specific	specific	JJ
cord-015021-pol2qm74	8760	11	growth	growth	NN
cord-015021-pol2qm74	8760	12	factors	factor	NNS
cord-015021-pol2qm74	8760	13	were	be	VBD
cord-015021-pol2qm74	8760	14	identified	identify	VBN
cord-015021-pol2qm74	8760	15	by	by	IN
cord-015021-pol2qm74	8760	16	reverse	reverse	JJ
cord-015021-pol2qm74	8760	17	-	-	HYPH
cord-015021-pol2qm74	8760	18	transcription	transcription	NN
cord-015021-pol2qm74	8760	19	polymerase	polymerase	NN
cord-015021-pol2qm74	8760	20	chain	chain	NN
cord-015021-pol2qm74	8760	21	reaction	reaction	NN
cord-015021-pol2qm74	8760	22	amplification	amplification	NN
cord-015021-pol2qm74	8760	23	,	,	,
cord-015021-pol2qm74	8760	24	&	&	CC
cord-015021-pol2qm74	8760	25	quantitated	quantitate	VBN
cord-015021-pol2qm74	8760	26	by	by	IN
cord-015021-pol2qm74	8760	27	gel	gel	NN
cord-015021-pol2qm74	8760	28	scans	scan	NNS
cord-015021-pol2qm74	8760	29	.	.	.
cord-015021-pol2qm74	8761	1	BB	BB	NNP
cord-015021-pol2qm74	8761	2	structure	structure	NN
cord-015021-pol2qm74	8761	3	was	be	VBD
cord-015021-pol2qm74	8761	4	studied	study	VBN
cord-015021-pol2qm74	8761	5	by	by	IN
cord-015021-pol2qm74	8761	6	scanning	scan	VBG
cord-015021-pol2qm74	8761	7	electron	electron	NN
cord-015021-pol2qm74	8761	8	microscopy	microscopy	NNP
cord-015021-pol2qm74	8761	9	&	&	CC
cord-015021-pol2qm74	8761	10	stretching	stretch	VBG
cord-015021-pol2qm74	8761	11	measurements	measurement	NNS
cord-015021-pol2qm74	8761	12	pro	pro	JJ
cord-015021-pol2qm74	8761	13	/	/	SYM
cord-015021-pol2qm74	8761	14	post	post	JJ
cord-015021-pol2qm74	8761	15	CRYO	CRYO	NNP
cord-015021-pol2qm74	8761	16	.	.	.
cord-015021-pol2qm74	8762	1	80	80	CD
cord-015021-pol2qm74	8762	2	grafts	graft	NNS
cord-015021-pol2qm74	8762	3	were	be	VBD
cord-015021-pol2qm74	8762	4	CRYO'd	CRYO'd	NNS
cord-015021-pol2qm74	8762	5	in	in	IN
cord-015021-pol2qm74	8762	6	10	10	CD
cord-015021-pol2qm74	8762	7	%	%	NN
cord-015021-pol2qm74	8762	8	DMSO	DMSO	NNP
cord-015021-pol2qm74	8762	9	,	,	,
cord-015021-pol2qm74	8762	10	quick	quick	RB
cord-015021-pol2qm74	8762	11	-	-	HYPH
cord-015021-pol2qm74	8762	12	thawed	thaw	VBN
cord-015021-pol2qm74	8762	13	&	&	CC
cord-015021-pol2qm74	8762	14	sutured	suture	VBN
cord-015021-pol2qm74	8762	15	onto	onto	IN
cord-015021-pol2qm74	8762	16	2X2	2x2	CD
cord-015021-pol2qm74	8762	17	cm	cm	NNS
cord-015021-pol2qm74	8762	18	excised	excise	VBN
cord-015021-pol2qm74	8762	19	full	full	JJ
cord-015021-pol2qm74	8762	20	-	-	HYPH
cord-015021-pol2qm74	8762	21	thickness	thickness	NN
cord-015021-pol2qm74	8762	22	dorsal	dorsal	JJ
cord-015021-pol2qm74	8762	23	wounds	wound	NNS
cord-015021-pol2qm74	8762	24	on	on	IN
cord-015021-pol2qm74	8762	25	athymic	athymic	JJ
cord-015021-pol2qm74	8762	26	mice	mouse	NNS
cord-015021-pol2qm74	8762	27	.	.	.
cord-015021-pol2qm74	8763	1	40	40	CD
cord-015021-pol2qm74	8763	2	"	"	``
cord-015021-pol2qm74	8763	3	fresh	fresh	JJ
cord-015021-pol2qm74	8763	4	"	"	''
cord-015021-pol2qm74	8763	5	grafts	graft	NNS
cord-015021-pol2qm74	8763	6	were	be	VBD
cord-015021-pol2qm74	8763	7	similarly	similarly	RB
cord-015021-pol2qm74	8763	8	placed	place	VBN
cord-015021-pol2qm74	8763	9	.	.	.
cord-015021-pol2qm74	8764	1	Controls	control	NNS
cord-015021-pol2qm74	8764	2	grafts	graft	NNS
cord-015021-pol2qm74	8764	3	were	be	VBD
cord-015021-pol2qm74	8764	4	CAS	CAS	NNP
cord-015021-pol2qm74	8764	5	and	and	CC
cord-015021-pol2qm74	8764	6	aeellular	aeellular	JJ
cord-015021-pol2qm74	8764	7	BB	BB	NNP
cord-015021-pol2qm74	8764	8	.	.	.
cord-015021-pol2qm74	8765	1	Adherence	adherence	NN
cord-015021-pol2qm74	8765	2	was	be	VBD
cord-015021-pol2qm74	8765	3	quantitated	quantitate	VBN
cord-015021-pol2qm74	8765	4	by	by	IN
cord-015021-pol2qm74	8765	5	a	a	DT
cord-015021-pol2qm74	8765	6	device	device	NN
cord-015021-pol2qm74	8765	7	which	which	WDT
cord-015021-pol2qm74	8765	8	peeled	peel	VBD
cord-015021-pol2qm74	8765	9	grafts	graft	NNS
cord-015021-pol2qm74	8765	10	from	from	IN
cord-015021-pol2qm74	8765	11	wounds	wound	NNS
cord-015021-pol2qm74	8765	12	at	at	IN
cord-015021-pol2qm74	8765	13	intervals	interval	NNS
cord-015021-pol2qm74	8765	14	following	follow	VBG
cord-015021-pol2qm74	8765	15	placement	placement	NN
cord-015021-pol2qm74	8765	16	,	,	,
cord-015021-pol2qm74	8765	17	using	use	VBG
cord-015021-pol2qm74	8765	18	a	a	DT
cord-015021-pol2qm74	8765	19	serve	serve	JJ
cord-015021-pol2qm74	8765	20	motor	motor	NN
cord-015021-pol2qm74	8765	21	and	and	CC
cord-015021-pol2qm74	8765	22	a	a	DT
cord-015021-pol2qm74	8765	23	strain	strain	NN
cord-015021-pol2qm74	8765	24	gauge	gauge	NN
cord-015021-pol2qm74	8765	25	.	.	.
cord-015021-pol2qm74	8766	1	RESULTS	result	NNS
cord-015021-pol2qm74	8766	2	:	:	:
cord-015021-pol2qm74	8767	1	PostCRYO	PostCRYO	NNP
cord-015021-pol2qm74	8767	2	,	,	,
cord-015021-pol2qm74	8767	3	storage	storage	NN
cord-015021-pol2qm74	8767	4	and	and	CC
cord-015021-pol2qm74	8767	5	subsequent	subsequent	JJ
cord-015021-pol2qm74	8767	6	thawing	thaw	VBG
cord-015021-pol2qm74	8767	7	tile	tile	NN
cord-015021-pol2qm74	8767	8	TLSRs	tlsr	NNS
cord-015021-pol2qm74	8767	9	maintained	maintain	VBD
cord-015021-pol2qm74	8767	10	>	>	:
cord-015021-pol2qm74	8767	11	60	60	CD
cord-015021-pol2qm74	8767	12	%	%	NN
cord-015021-pol2qm74	8767	13	cell	cell	NN
cord-015021-pol2qm74	8767	14	viability	viability	NN
cord-015021-pol2qm74	8767	15	by	by	IN
cord-015021-pol2qm74	8767	16	the	the	DT
cord-015021-pol2qm74	8767	17	MTT	MTT	NNP
cord-015021-pol2qm74	8767	18	assay	assay	NN
cord-015021-pol2qm74	8767	19	,	,	,
cord-015021-pol2qm74	8767	20	indicating	indicate	VBG
cord-015021-pol2qm74	8767	21	continued	continue	VBN
cord-015021-pol2qm74	8767	22	mitochondrial	mitochondrial	JJ
cord-015021-pol2qm74	8767	23	activity	activity	NN
cord-015021-pol2qm74	8767	24	,	,	,
cord-015021-pol2qm74	8767	25	and	and	CC
cord-015021-pol2qm74	8767	26	BB	BB	NNP
cord-015021-pol2qm74	8767	27	structure	structure	NN
cord-015021-pol2qm74	8767	28	&	&	CC
cord-015021-pol2qm74	8767	29	stretchability	stretchability	NN
cord-015021-pol2qm74	8767	30	were	be	VBD
cord-015021-pol2qm74	8767	31	maintained	maintain	VBN
cord-015021-pol2qm74	8767	32	.	.	.
cord-015021-pol2qm74	8768	1	Multiple	multiple	JJ
cord-015021-pol2qm74	8768	2	matrix	matrix	NN
cord-015021-pol2qm74	8768	3	proteins	protein	NNS
cord-015021-pol2qm74	8768	4	secreted	secrete	VBN
cord-015021-pol2qm74	8768	5	and	and	CC
cord-015021-pol2qm74	8768	6	deposited	deposit	VBN
cord-015021-pol2qm74	8768	7	in	in	IN
cord-015021-pol2qm74	8768	8	the	the	DT
cord-015021-pol2qm74	8768	9	BB	bb	NN
cord-015021-pol2qm74	8768	10	nylon	nylon	NN
cord-015021-pol2qm74	8768	11	mesh	mesh	NN
cord-015021-pol2qm74	8768	12	(	(	-LRB-
cord-015021-pol2qm74	8768	13	types	type	NNS
cord-015021-pol2qm74	8768	14	l	l	NN
cord-015021-pol2qm74	8768	15	/	/	SYM
cord-015021-pol2qm74	8768	16	III	iii	CD
cord-015021-pol2qm74	8768	17	collagen	collagen	NN
cord-015021-pol2qm74	8768	18	,	,	,
cord-015021-pol2qm74	8768	19	decorin	decorin	NNP
cord-015021-pol2qm74	8768	20	,	,	,
cord-015021-pol2qm74	8768	21	fibroneetin	fibroneetin	NNP
cord-015021-pol2qm74	8768	22	)	)	-RRB-
cord-015021-pol2qm74	8768	23	were	be	VBD
cord-015021-pol2qm74	8768	24	identified	identify	VBN
cord-015021-pol2qm74	8768	25	by	by	IN
cord-015021-pol2qm74	8768	26	specific	specific	JJ
cord-015021-pol2qm74	8768	27	immunostaining	immunostaining	NN
cord-015021-pol2qm74	8768	28	.	.	.
cord-015021-pol2qm74	8769	1	Growth	growth	NN
cord-015021-pol2qm74	8769	2	factor	factor	NN
cord-015021-pol2qm74	8769	3	mRNAs	mrnas	XX
cord-015021-pol2qm74	8769	4	in	in	IN
cord-015021-pol2qm74	8769	5	the	the	DT
cord-015021-pol2qm74	8769	6	TLSRs	tlsr	NNS
cord-015021-pol2qm74	8769	7	(	(	-LRB-
cord-015021-pol2qm74	8769	8	aFGF	afgf	RB
cord-015021-pol2qm74	8769	9	,	,	,
cord-015021-pol2qm74	8769	10	bFGF	bfgf	NN
cord-015021-pol2qm74	8769	11	,	,	,
cord-015021-pol2qm74	8769	12	KGF	KGF	NNP
cord-015021-pol2qm74	8769	13	,	,	,
cord-015021-pol2qm74	8769	14	TGF~,p~	TGF~,p~	NNP
cord-015021-pol2qm74	8769	15	,	,	,
cord-015021-pol2qm74	8769	16	)	)	-RRB-
cord-015021-pol2qm74	8769	17	were	be	VBD
cord-015021-pol2qm74	8769	18	present	present	JJ
cord-015021-pol2qm74	8769	19	in	in	IN
cord-015021-pol2qm74	8769	20	10	10	CD
cord-015021-pol2qm74	8769	21	-	-	SYM
cord-015021-pol2qm74	8769	22	10,000X	10,000x	CD
cord-015021-pol2qm74	8769	23	higher	high	JJR
cord-015021-pol2qm74	8769	24	levels	level	NNS
cord-015021-pol2qm74	8769	25	in	in	IN
cord-015021-pol2qm74	8769	26	fresh	fresh	JJ
cord-015021-pol2qm74	8769	27	/	/	SYM
cord-015021-pol2qm74	8769	28	CRYO	CRYO	NNP
cord-015021-pol2qm74	8769	29	TLSRs	tlsr	NNS
cord-015021-pol2qm74	8769	30	than	than	IN
cord-015021-pol2qm74	8769	31	in	in	IN
cord-015021-pol2qm74	8769	32	adult	adult	NN
cord-015021-pol2qm74	8769	33	HCS	HCS	NNP
cord-015021-pol2qm74	8769	34	.	.	.
cord-015021-pol2qm74	8770	1	Grafts	graft	NNS
cord-015021-pol2qm74	8770	2	adhered	adhere	VBD
cord-015021-pol2qm74	8770	3	to	to	IN
cord-015021-pol2qm74	8770	4	wounds	wound	NNS
cord-015021-pol2qm74	8770	5	on	on	IN
cord-015021-pol2qm74	8770	6	mice	mouse	NNS
cord-015021-pol2qm74	8770	7	through	through	IN
cord-015021-pol2qm74	8770	8	40	40	CD
cord-015021-pol2qm74	8770	9	days	day	NNS
cord-015021-pol2qm74	8770	10	of	of	IN
cord-015021-pol2qm74	8770	11	followup	followup	NN
cord-015021-pol2qm74	8770	12	.	.	.
cord-015021-pol2qm74	8771	1	Histologic	Histologic	NNP
cord-015021-pol2qm74	8771	2	exams	exam	NNS
cord-015021-pol2qm74	8771	3	on	on	IN
cord-015021-pol2qm74	8771	4	days	day	NNS
cord-015021-pol2qm74	8771	5	6	6	CD
cord-015021-pol2qm74	8771	6	-	-	SYM
cord-015021-pol2qm74	8771	7	40	40	CD
cord-015021-pol2qm74	8771	8	showed	show	VBD
cord-015021-pol2qm74	8771	9	excellent	excellent	JJ
cord-015021-pol2qm74	8771	10	vascular	vascular	JJ
cord-015021-pol2qm74	8771	11	ingrowth	ingrowth	NN
cord-015021-pol2qm74	8771	12	and	and	CC
cord-015021-pol2qm74	8771	13	minimal	minimal	JJ
cord-015021-pol2qm74	8771	14	inflammation	inflammation	NN
cord-015021-pol2qm74	8771	15	.	.	.
cord-015021-pol2qm74	8772	1	Adherence	adherence	NN
cord-015021-pol2qm74	8772	2	of	of	IN
cord-015021-pol2qm74	8772	3	TLSRs	tlsr	NNS
cord-015021-pol2qm74	8772	4	to	to	IN
cord-015021-pol2qm74	8772	5	wounds	wound	NNS
cord-015021-pol2qm74	8772	6	was	be	VBD
cord-015021-pol2qm74	8772	7	>	>	XX
cord-015021-pol2qm74	8772	8	CAS	CAS	NNP
cord-015021-pol2qm74	8772	9	adherence	adherence	NN
cord-015021-pol2qm74	8772	10	.	.	.
cord-015021-pol2qm74	8773	1	Burn	burn	VB
cord-015021-pol2qm74	8773	2	wound	wound	JJ
cord-015021-pol2qm74	8773	3	coverage	coverage	NN
cord-015021-pol2qm74	8773	4	in	in	IN
cord-015021-pol2qm74	8773	5	the	the	DT
cord-015021-pol2qm74	8773	6	massively	massively	RB
cord-015021-pol2qm74	8773	7	burned	burn	VBN
cord-015021-pol2qm74	8773	8	patient	patient	NN
cord-015021-pol2qm74	8773	9	remains	remain	VBZ
cord-015021-pol2qm74	8773	10	a	a	DT
cord-015021-pol2qm74	8773	11	difficult	difficult	JJ
cord-015021-pol2qm74	8773	12	problem	problem	NN
cord-015021-pol2qm74	8773	13	.	.	.
cord-015021-pol2qm74	8774	1	Although	although	IN
cord-015021-pol2qm74	8774	2	cultured	cultured	JJ
cord-015021-pol2qm74	8774	3	keratinocytes	keratinocyte	NNS
cord-015021-pol2qm74	8774	4	have	have	VBP
cord-015021-pol2qm74	8774	5	been	be	VBN
cord-015021-pol2qm74	8774	6	utilized	utilize	VBN
cord-015021-pol2qm74	8774	7	for	for	IN
cord-015021-pol2qm74	8774	8	burn	burn	NN
cord-015021-pol2qm74	8774	9	wound	wound	NN
cord-015021-pol2qm74	8774	10	coverage	coverage	NN
cord-015021-pol2qm74	8774	11	,	,	,
cord-015021-pol2qm74	8774	12	their	-PRON-	PRP$
cord-015021-pol2qm74	8774	13	impact	impact	NN
cord-015021-pol2qm74	8774	14	on	on	IN
cord-015021-pol2qm74	8774	15	the	the	DT
cord-015021-pol2qm74	8774	16	patient	patient	NN
cord-015021-pol2qm74	8774	17	with	with	IN
cord-015021-pol2qm74	8774	18	burns	burn	NNS
cord-015021-pol2qm74	8774	19	greater	great	JJR
cord-015021-pol2qm74	8774	20	than	than	IN
cord-015021-pol2qm74	8774	21	80	80	CD
cord-015021-pol2qm74	8774	22	%	%	NN
cord-015021-pol2qm74	8774	23	total	total	JJ
cord-015021-pol2qm74	8774	24	body	body	NN
cord-015021-pol2qm74	8774	25	surface	surface	NN
cord-015021-pol2qm74	8774	26	area	area	NN
cord-015021-pol2qm74	8774	27	has	have	VBZ
cord-015021-pol2qm74	8774	28	not	not	RB
cord-015021-pol2qm74	8774	29	been	be	VBN
cord-015021-pol2qm74	8774	30	spectacular	spectacular	JJ
cord-015021-pol2qm74	8774	31	,	,	,
cord-015021-pol2qm74	8774	32	with	with	IN
cord-015021-pol2qm74	8774	33	poor	poor	JJ
cord-015021-pol2qm74	8774	34	graft	graft	NN
cord-015021-pol2qm74	8774	35	take	take	NN
cord-015021-pol2qm74	8774	36	and	and	CC
cord-015021-pol2qm74	8774	37	unstable	unstable	JJ
cord-015021-pol2qm74	8774	38	epithelium	epithelium	NN
cord-015021-pol2qm74	8774	39	.	.	.
cord-015021-pol2qm74	8775	1	Current	current	JJ
cord-015021-pol2qm74	8775	2	investigations	investigation	NNS
cord-015021-pol2qm74	8775	3	have	have	VBP
cord-015021-pol2qm74	8775	4	been	be	VBN
cord-015021-pol2qm74	8775	5	directed	direct	VBN
cord-015021-pol2qm74	8775	6	toward	toward	IN
cord-015021-pol2qm74	8775	7	dermal	dermal	JJ
cord-015021-pol2qm74	8775	8	replacement	replacement	NN
cord-015021-pol2qm74	8775	9	beneath	beneath	IN
cord-015021-pol2qm74	8775	10	either	either	CC
cord-015021-pol2qm74	8775	11	very	very	RB
cord-015021-pol2qm74	8775	12	thin	thin	JJ
cord-015021-pol2qm74	8775	13	split	split	NN
cord-015021-pol2qm74	8775	14	-	-	HYPH
cord-015021-pol2qm74	8775	15	thickness	thickness	NN
cord-015021-pol2qm74	8775	16	autografts	autografts	NN
cord-015021-pol2qm74	8775	17	(	(	-LRB-
cord-015021-pol2qm74	8775	18	STAG	STAG	NNP
cord-015021-pol2qm74	8775	19	)	)	-RRB-
cord-015021-pol2qm74	8775	20	or	or	CC
cord-015021-pol2qm74	8775	21	utilizing	utilize	VBG
cord-015021-pol2qm74	8775	22	cultured	cultured	JJ
cord-015021-pol2qm74	8775	23	keratinocytes	keratinocyte	NNS
cord-015021-pol2qm74	8775	24	.	.	.
cord-015021-pol2qm74	8776	1	Current	current	JJ
cord-015021-pol2qm74	8776	2	products	product	NNS
cord-015021-pol2qm74	8776	3	include	include	VBP
cord-015021-pol2qm74	8776	4	:	:	:
cord-015021-pol2qm74	8776	5	Collagen	collagen	NN
cord-015021-pol2qm74	8776	6	dermal	dermal	JJ
cord-015021-pol2qm74	8776	7	replacement	replacement	NN
cord-015021-pol2qm74	8776	8	with	with	IN
cord-015021-pol2qm74	8776	9	thin	thin	JJ
cord-015021-pol2qm74	8776	10	STAG	STAG	NNP
cord-015021-pol2qm74	8776	11	(	(	-LRB-
cord-015021-pol2qm74	8776	12	Burke	Burke	NNP
cord-015021-pol2qm74	8776	13	,	,	,
cord-015021-pol2qm74	8776	14	et	et	NNP
cord-015021-pol2qm74	8776	15	al	al	NNP
cord-015021-pol2qm74	8776	16	)	)	-RRB-
cord-015021-pol2qm74	8776	17	.	.	.
cord-015021-pol2qm74	8777	1	Collagen	collagen	NN
cord-015021-pol2qm74	8777	2	dermal	dermal	JJ
cord-015021-pol2qm74	8777	3	replacement	replacement	NN
cord-015021-pol2qm74	8777	4	with	with	IN
cord-015021-pol2qm74	8777	5	cultured	cultured	JJ
cord-015021-pol2qm74	8777	6	keratinocytes	keratinocyte	NNS
cord-015021-pol2qm74	8777	7	and	and	CC
cord-015021-pol2qm74	8777	8	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	8777	9	(	(	-LRB-
cord-015021-pol2qm74	8777	10	Boyce	Boyce	NNP
cord-015021-pol2qm74	8777	11	,	,	,
cord-015021-pol2qm74	8777	12	et	et	NNP
cord-015021-pol2qm74	8777	13	aI	aI	NNP
cord-015021-pol2qm74	8777	14	)	)	-RRB-
cord-015021-pol2qm74	8777	15	.	.	.
cord-015021-pol2qm74	8778	1	Allograft	Allograft	NNP
cord-015021-pol2qm74	8778	2	dermis	dermis	NN
cord-015021-pol2qm74	8778	3	with	with	IN
cord-015021-pol2qm74	8778	4	cultured	cultured	JJ
cord-015021-pol2qm74	8778	5	keratinocytes	keratinocyte	NNS
cord-015021-pol2qm74	8778	6	(	(	-LRB-
cord-015021-pol2qm74	8778	7	Cnno	Cnno	NNP
cord-015021-pol2qm74	8778	8	,	,	,
cord-015021-pol2qm74	8778	9	et	et	NNP
cord-015021-pol2qm74	8778	10	al	al	NNP
cord-015021-pol2qm74	8778	11	)	)	-RRB-
cord-015021-pol2qm74	8778	12	.	.	.
cord-015021-pol2qm74	8779	1	Allograft	Allograft	NNP
cord-015021-pol2qm74	8779	2	dermis	dermis	NN
cord-015021-pol2qm74	8779	3	with	with	IN
cord-015021-pol2qm74	8779	4	thin	thin	JJ
cord-015021-pol2qm74	8779	5	STAG	stag	NN
cord-015021-pol2qm74	8779	6	(	(	-LRB-
cord-015021-pol2qm74	8779	7	Life	Life	NNP
cord-015021-pol2qm74	8779	8	Cell	Cell	NNP
cord-015021-pol2qm74	8779	9	)	)	-RRB-
cord-015021-pol2qm74	8779	10	.	.	.
cord-015021-pol2qm74	8780	1	Polyglactin	Polyglactin	NNP
cord-015021-pol2qm74	8780	2	acid	acid	NN
cord-015021-pol2qm74	8780	3	mesh	mesh	NN
cord-015021-pol2qm74	8780	4	and	and	CC
cord-015021-pol2qm74	8780	5	neonatal	neonatal	JJ
cord-015021-pol2qm74	8780	6	human	human	JJ
cord-015021-pol2qm74	8780	7	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	8780	8	with	with	IN
cord-015021-pol2qm74	8780	9	thin	thin	JJ
cord-015021-pol2qm74	8780	10	STAG	stag	NN
cord-015021-pol2qm74	8780	11	(	(	-LRB-
cord-015021-pol2qm74	8780	12	Hansbrnngh	Hansbrnngh	NNP
cord-015021-pol2qm74	8780	13	,	,	,
cord-015021-pol2qm74	8780	14	et	et	NNP
cord-015021-pol2qm74	8780	15	al).Investigations	al).Investigations	NNP
cord-015021-pol2qm74	8780	16	regarding	regard	VBG
cord-015021-pol2qm74	8780	17	culture	culture	NN
cord-015021-pol2qm74	8780	18	media	medium	NNS
cord-015021-pol2qm74	8780	19	,	,	,
cord-015021-pol2qm74	8780	20	use	use	NN
cord-015021-pol2qm74	8780	21	of	of	IN
cord-015021-pol2qm74	8780	22	growth	growth	NN
cord-015021-pol2qm74	8780	23	factors	factor	NNS
cord-015021-pol2qm74	8780	24	,	,	,
cord-015021-pol2qm74	8780	25	topical	topical	JJ
cord-015021-pol2qm74	8780	26	nutrients	nutrient	NNS
cord-015021-pol2qm74	8780	27	and	and	CC
cord-015021-pol2qm74	8780	28	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	8780	29	,	,	,
cord-015021-pol2qm74	8780	30	and	and	CC
cord-015021-pol2qm74	8780	31	melanocytes	melanocyte	NNS
cord-015021-pol2qm74	8780	32	for	for	IN
cord-015021-pol2qm74	8780	33	pigmentation	pigmentation	NN
cord-015021-pol2qm74	8780	34	as	as	RB
cord-015021-pol2qm74	8780	35	well	well	RB
cord-015021-pol2qm74	8780	36	as	as	IN
cord-015021-pol2qm74	8780	37	safety	safety	NN
cord-015021-pol2qm74	8780	38	and	and	CC
cord-015021-pol2qm74	8780	39	efficacy	efficacy	NN
cord-015021-pol2qm74	8780	40	are	be	VBP
cord-015021-pol2qm74	8780	41	needed	need	VBN
cord-015021-pol2qm74	8780	42	before	before	IN
cord-015021-pol2qm74	8780	43	any	any	DT
cord-015021-pol2qm74	8780	44	of	of	IN
cord-015021-pol2qm74	8780	45	the	the	DT
cord-015021-pol2qm74	8780	46	current	current	JJ
cord-015021-pol2qm74	8780	47	products	product	NNS
cord-015021-pol2qm74	8780	48	become	become	VBP
cord-015021-pol2qm74	8780	49	viable	viable	JJ
cord-015021-pol2qm74	8780	50	options	option	NNS
cord-015021-pol2qm74	8780	51	for	for	IN
cord-015021-pol2qm74	8780	52	coverage	coverage	NN
cord-015021-pol2qm74	8780	53	of	of	IN
cord-015021-pol2qm74	8780	54	the	the	DT
cord-015021-pol2qm74	8780	55	massively	massively	RB
cord-015021-pol2qm74	8780	56	burned	burn	VBN
cord-015021-pol2qm74	8780	57	patient	patient	NN
cord-015021-pol2qm74	8780	58	.	.	.
cord-015021-pol2qm74	8781	1	The~	The~	NNP
cord-015021-pol2qm74	8781	2	is	be	VBZ
cord-015021-pol2qm74	8781	3	a	a	DT
cord-015021-pol2qm74	8781	4	growing	grow	VBG
cord-015021-pol2qm74	8781	5	world	world	NN
cord-015021-pol2qm74	8781	6	-	-	HYPH
cord-015021-pol2qm74	8781	7	wide	wide	JJ
cord-015021-pol2qm74	8781	8	problem	problem	NN
cord-015021-pol2qm74	8781	9	with	with	IN
cord-015021-pol2qm74	8781	10	the	the	DT
cord-015021-pol2qm74	8781	11	uJc	ujc	NN
cord-015021-pol2qm74	8781	12	Of	of	IN
cord-015021-pol2qm74	8781	13	cadaver	cadaver	NN
cord-015021-pol2qm74	8781	14	tissues	tissue	NNS
cord-015021-pol2qm74	8781	15	and	and	CC
cord-015021-pol2qm74	8781	16	ocgans	ocgans	NNP
cord-015021-pol2qm74	8781	17	bae	bae	NNP
cord-015021-pol2qm74	8781	18	,	,	,
cord-015021-pol2qm74	8781	19	au~	au~	JJ
cord-015021-pol2qm74	8781	20	of	of	IN
cord-015021-pol2qm74	8781	21	the	the	DT
cord-015021-pol2qm74	8781	22	tren~	tren~	NNP
cord-015021-pol2qm74	8782	1	m	m	LS
cord-015021-pol2qm74	8783	1	~s	~s	NNP
cord-015021-pol2qm74	8783	2	~	~	NFP
cord-015021-pol2qm74	8783	3	km	km	NN
cord-015021-pol2qm74	8783	4	of	of	IN
cord-015021-pol2qm74	8783	5	dilemma	dilemma	NN
cord-015021-pol2qm74	8783	6	such	such	PDT
cord-015021-pol2qm74	8783	7	a	a	DT
cord-015021-pol2qm74	8784	1	;	;	:
cord-015021-pol2qm74	8784	2	Cmutzfeldt	Cmutzfeldt	NNP
cord-015021-pol2qm74	8784	3	.	.	.
cord-015021-pol2qm74	8785	1	Jukob	Jukob	NNP
cord-015021-pol2qm74	8785	2	disease	disease	NN
cord-015021-pol2qm74	8785	3	and	and	CC
cord-015021-pol2qm74	8785	4	IIIV	IIIV	NNP
cord-015021-pol2qm74	8785	5	as	as	IN
cord-015021-pol2qm74	8785	6	we1	we1	NN
cord-015021-pol2qm74	8785	7	]	]	-RRB-
cord-015021-pol2qm74	8785	8	as	as	IN
cord-015021-pol2qm74	8785	9	ready	ready	JJ
cord-015021-pol2qm74	8785	10	availability	availability	NN
cord-015021-pol2qm74	8785	11	of	of	IN
cord-015021-pol2qm74	8785	12	urdform	urdform	NNP
cord-015021-pol2qm74	8785	13	liS	lis	NN
cord-015021-pol2qm74	8786	1	~ue~.	~ue~.	NNP
cord-015021-pol2qm74	8787	1	On	on	IN
cord-015021-pol2qm74	8788	1	Dec~	Dec~	NNP
cord-015021-pol2qm74	8789	1	mt	mt	NNP
cord-015021-pol2qm74	8790	1	~r	~r	NNP
cord-015021-pol2qm74	8790	2	14	14	CD
cord-015021-pol2qm74	8790	3	,	,	,
cord-015021-pol2qm74	8790	4	1993	1993	CD
cord-015021-pol2qm74	8790	5	,	,	,
cord-015021-pol2qm74	8790	6	the	the	DT
cord-015021-pol2qm74	8790	7	FDA	FDA	NNP
cord-015021-pol2qm74	8790	8	assumed	assume	VBD
cord-015021-pol2qm74	8790	9	control	control	NN
cord-015021-pol2qm74	8790	10	of	of	IN
cord-015021-pol2qm74	8790	11	aS1	as1	JJ
cord-015021-pol2qm74	8790	12	tissue	tissue	NN
cord-015021-pol2qm74	8790	13	bar	bar	NN
cord-015021-pol2qm74	8790	14	~	~	NFP
cord-015021-pol2qm74	8790	15	s	s	XX
cord-015021-pol2qm74	8790	16	in	in	IN
cord-015021-pol2qm74	8790	17	the	the	DT
cord-015021-pol2qm74	8790	18	Uldtod	Uldtod	NNP
cord-015021-pol2qm74	8790	19	St	St	NNP
cord-015021-pol2qm74	8790	20	=	=	SYM
cord-015021-pol2qm74	8790	21	tea	tea	NN
cord-015021-pol2qm74	8791	1	In	in	IN
cord-015021-pol2qm74	8791	2	an	an	DT
cord-015021-pol2qm74	8791	3	attempt	attempt	NN
cord-015021-pol2qm74	8791	4	to	to	IN
cord-015021-pol2qm74	8791	5	bflng	bflng	NNP
cord-015021-pol2qm74	8792	1	~s	~s	NNP
cord-015021-pol2qm74	8792	2	difficult	difficult	JJ
cord-015021-pol2qm74	8792	3	problem	problem	NN
cord-015021-pol2qm74	8792	4	of	of	IN
cord-015021-pol2qm74	8792	5	dise	dise	NNP
cord-015021-pol2qm74	8792	6	~	~	NFP
cord-015021-pol2qm74	8792	7	s~	s~	CD
cord-015021-pol2qm74	8792	8	transmission	transmission	NN
cord-015021-pol2qm74	8792	9	under	under	IN
cord-015021-pol2qm74	8792	10	¢onlrol	¢onlrol	NN
cord-015021-pol2qm74	8792	11	.	.	.
cord-015021-pol2qm74	8793	1	In	in	IN
cord-015021-pol2qm74	8793	2	Europe	Europe	NNP
cord-015021-pol2qm74	8793	3	,	,	,
cord-015021-pol2qm74	8793	4	~om¢	~om¢	CD
cord-015021-pol2qm74	8793	5	of	of	IN
cord-015021-pol2qm74	8793	6	the	the	DT
cord-015021-pol2qm74	8793	7	governments	government	NNS
cord-015021-pol2qm74	8793	8	are	be	VBP
cord-015021-pol2qm74	8793	9	consldofll~	consldofll~	VBZ
cord-015021-pol2qm74	8793	10	a	a	DT
cord-015021-pol2qm74	8793	11	c	c	NN
cord-015021-pol2qm74	8793	12	~	~	NFP
cord-015021-pol2qm74	8793	13	mplcte	mplcte	NNP
cord-015021-pol2qm74	8793	14	bat	bat	NNP
cord-015021-pol2qm74	8793	15	)	)	-RRB-
cord-015021-pol2qm74	8793	16	on	on	IN
cord-015021-pol2qm74	8793	17	the	the	DT
cord-015021-pol2qm74	8793	18	use	use	NN
cord-015021-pol2qm74	8793	19	of	of	IN
cord-015021-pol2qm74	8793	20	cadaverlc	cadaverlc	NNP
cord-015021-pol2qm74	8793	21	fissu	fissu	NNP
cord-015021-pol2qm74	8793	22	~	~	NFP
cord-015021-pol2qm74	8793	23	S	S	NNP
cord-015021-pol2qm74	8793	24	such	such	JJ
cord-015021-pol2qm74	8793	25	as	as	IN
cord-015021-pol2qm74	8793	26	ddn	ddn	NNP
cord-015021-pol2qm74	8793	27	,	,	,
cord-015021-pol2qm74	8793	28	'	'	``
cord-015021-pol2qm74	8793	29	This	this	DT
cord-015021-pol2qm74	8793	30	|ncroam	|ncroam	NNP
cord-015021-pol2qm74	8793	31	in	in	IN
cord-015021-pol2qm74	8793	32	regulation	regulation	NN
cord-015021-pol2qm74	8793	33	of	of	IN
cord-015021-pol2qm74	8793	34	cadavefle	cadavefle	NN
cord-015021-pol2qm74	8794	1	~s	~s	NNP
cord-015021-pol2qm74	8795	1	,	,	,
cord-015021-pol2qm74	8795	2	quct	quct	NNP
cord-015021-pol2qm74	8795	3	will	will	MD
cord-015021-pol2qm74	8795	4	incmar¢	incmar¢	VB
cord-015021-pol2qm74	8795	5	the	the	DT
cord-015021-pol2qm74	8795	6	difficulty	difficulty	NN
cord-015021-pol2qm74	8795	7	of	of	IN
cord-015021-pol2qm74	8795	8	obtain	obtain	VB
cord-015021-pol2qm74	8795	9	~	~	NFP
cord-015021-pol2qm74	8795	10	g	g	NN
cord-015021-pol2qm74	8795	11	and	and	CC
cord-015021-pol2qm74	8795	12	dlslflbuLmg	dlslflbuLmg	NNP
cord-015021-pol2qm74	8795	13	them	-PRON-	PRP
cord-015021-pol2qm74	8795	14	.	.	.
cord-015021-pol2qm74	8796	1	However	however	RB
cord-015021-pol2qm74	8796	2	,	,	,
cord-015021-pol2qm74	8796	3	thc	thc	NNP
cord-015021-pol2qm74	8796	4	nc~	nc~	NN
cord-015021-pol2qm74	8796	5	for	for	IN
cord-015021-pol2qm74	8796	6	these	these	DT
cord-015021-pol2qm74	8796	7	tissues	tissue	NNS
cord-015021-pol2qm74	8797	1	contlnue~	contlnue~	NNP
cord-015021-pol2qm74	8797	2	m	m	CD
cord-015021-pol2qm74	8797	3	incrcaso	incrcaso	NNP
cord-015021-pol2qm74	8798	1	,	,	,
cord-015021-pol2qm74	8798	2	We	-PRON-	PRP
cord-015021-pol2qm74	8798	3	will	will	MD
cord-015021-pol2qm74	8798	4	discuss	discuss	VB
cord-015021-pol2qm74	8798	5	~'L¢	~'l¢	CD
cord-015021-pol2qm74	8798	6	solulion	solulion	NN
cord-015021-pol2qm74	8798	7	to	to	IN
cord-015021-pol2qm74	8798	8	this	this	DT
cord-015021-pol2qm74	8798	9	Important	Important	NNP
cord-015021-pol2qm74	8798	10	pmbl~	pmbl~	NNP
cord-015021-pol2qm74	8799	1	n	n	CC
cord-015021-pol2qm74	8799	2	:	:	:
cord-015021-pol2qm74	8799	3	Tissue	tissue	NN
cord-015021-pol2qm74	8799	4	Engineering	Engineering	NNP
cord-015021-pol2qm74	8799	5	.	.	.
cord-015021-pol2qm74	8800	1	Tlssu~	tlssu~	CD
cord-015021-pol2qm74	8801	1	Engineering	engineering	NN
cord-015021-pol2qm74	8801	2	is	be	VBZ
cord-015021-pol2qm74	8801	3	an	an	DT
cord-015021-pol2qm74	8801	4	in	in	IN
cord-015021-pol2qm74	8801	5	~	~	NFP
cord-015021-pol2qm74	8801	6	rdisdpllnary	rdisdpllnary	NNP
cord-015021-pol2qm74	8801	7	field	field	NN
cord-015021-pol2qm74	8801	8	that	that	WDT
cord-015021-pol2qm74	8801	9	applies	apply	VBZ
cord-015021-pol2qm74	8801	10	pdnclplc~	pdnclplc~	NNP
cord-015021-pol2qm74	8801	11	of	of	IN
cord-015021-pol2qm74	8801	12	angin	angin	NNP
cord-015021-pol2qm74	8801	13	~	~	NFP
cord-015021-pol2qm74	8801	14	edng	edng	NNP
cord-015021-pol2qm74	8801	15	and	and	CC
cord-015021-pol2qm74	8801	16	die	die	VB
cord-015021-pol2qm74	8801	17	life	life	NN
cord-015021-pol2qm74	8802	1	sclcnce~	sclcnce~	NNP
cord-015021-pol2qm74	8802	2	reward	reward	VB
cord-015021-pol2qm74	8802	3	the	the	DT
cord-015021-pol2qm74	8802	4	development	development	NN
cord-015021-pol2qm74	8802	5	of	of	IN
cord-015021-pol2qm74	8802	6	~olok~¢al	~olok~¢al	NFP
cord-015021-pol2qm74	8802	7	sub	sub	NNP
cord-015021-pol2qm74	8802	8	~	~	NNP
cord-015021-pol2qm74	8802	9	dtute,~	dtute,~	JJ
cord-015021-pol2qm74	8802	10	Ih=	Ih=	NNP
cord-015021-pol2qm74	8802	11	mslom	mslom	NN
cord-015021-pol2qm74	8802	12	,	,	,
cord-015021-pol2qm74	8802	13	maintain	maintain	VB
cord-015021-pol2qm74	8802	14	,	,	,
cord-015021-pol2qm74	8802	15	or	or	CC
cord-015021-pol2qm74	8802	16	improve	improve	VB
cord-015021-pol2qm74	8802	17	tissue	tissue	NN
cord-015021-pol2qm74	8802	18	function	function	NN
cord-015021-pol2qm74	8802	19	,	,	.
cord-015021-pol2qm74	8803	1	"	"	``
cord-015021-pol2qm74	8803	2	13ssuc	13ssuc	CD
cord-015021-pol2qm74	8803	3	ongln	ongln	NN
cord-015021-pol2qm74	8804	1	~cdng	~cdng	NNP
cord-015021-pol2qm74	8804	2	can	can	MD
cord-015021-pol2qm74	8804	3	provide	provide	VB
cord-015021-pol2qm74	8804	4	~ho	~ho	NNS
cord-015021-pol2qm74	8805	1	nccassary	nccassary	NNP
cord-015021-pol2qm74	8805	2	tlssuoa	tlssuoa	NNP
cord-015021-pol2qm74	8805	3	for	for	IN
cord-015021-pol2qm74	8805	4	wound	wound	NN
cord-015021-pol2qm74	8805	5	repair	repair	NN
cord-015021-pol2qm74	8806	1	~d	~d	.
cord-015021-pol2qm74	8807	1	Ibe	Ibe	NNP
cord-015021-pol2qm74	8807	2	assuranoe	assuranoe	NNP
cord-015021-pol2qm74	8807	3	fl'~t	fl'~t	NNP
cord-015021-pol2qm74	8808	1	the	the	DT
cord-015021-pol2qm74	8808	2	lissuos	lissuos	NNP
cord-015021-pol2qm74	8808	3	are	be	VBP
cord-015021-pol2qm74	8808	4	d.ls¢~¢	d.ls¢~¢	CD
cord-015021-pol2qm74	8808	5	free	free	JJ
cord-015021-pol2qm74	8808	6	.	.	.
cord-015021-pol2qm74	8809	1	In	in	IN
cord-015021-pol2qm74	8809	2	addition	addition	NN
cord-015021-pol2qm74	8809	3	,	,	,
cord-015021-pol2qm74	8809	4	a	a	DT
cord-015021-pol2qm74	8809	5	ds	ds	NNP
cord-015021-pol2qm74	8809	6	~	~	NNP
cord-015021-pol2qm74	8809	7	uo	uo	NNP
cord-015021-pol2qm74	8809	8	-	-	HYPH
cord-015021-pol2qm74	8809	9	cng	cng	NNP
cord-015021-pol2qm74	8809	10	~	~	NNP
cord-015021-pol2qm74	8809	11	ne	ne	NNP
cord-015021-pol2qm74	8809	12	~	~	NNP
cord-015021-pol2qm74	8809	13	n	n	NN
cord-015021-pol2qm74	8809	14	~	~	NFP
cord-015021-pol2qm74	8809	15	l	l	NNP
cord-015021-pol2qm74	8809	16	wound	wound	NNP
cord-015021-pol2qm74	8809	17	covering	cover	VBG
cord-015021-pol2qm74	8809	18	will	will	MD
cord-015021-pol2qm74	8809	19	bo	bo	NNP
cord-015021-pol2qm74	8809	20	u	u	NNP
cord-015021-pol2qm74	8809	21	~	~	NFP
cord-015021-pol2qm74	8809	22	lvemally	lvemally	RB
cord-015021-pol2qm74	8809	23	acceptable	acceptable	JJ
cord-015021-pol2qm74	8809	24	and	and	CC
cord-015021-pol2qm74	8809	25	evntlublc	evntlublc	JJ
cord-015021-pol2qm74	8809	26	as	as	IN
cord-015021-pol2qm74	8809	27	"	"	``
cord-015021-pol2qm74	8809	28	off	off	IN
cord-015021-pol2qm74	8809	29	G	g	NN
cord-015021-pol2qm74	8809	30	~	~	NFP
cord-015021-pol2qm74	8809	31	o	o	UH
cord-015021-pol2qm74	8809	32	shell	shell	NN
cord-015021-pol2qm74	8809	33	"	"	''
cord-015021-pol2qm74	8809	34	,	,	,
cord-015021-pol2qm74	8809	35	consis	consis	NNP
cord-015021-pol2qm74	8809	36	~	~	NFP
cord-015021-pol2qm74	8809	37	t	t	NNP
cord-015021-pol2qm74	8809	38	products	product	NNS
cord-015021-pol2qm74	8809	39	,	,	,
cord-015021-pol2qm74	8809	40	Them	-PRON-	PRP
cord-015021-pol2qm74	8809	41	are	be	VBP
cord-015021-pol2qm74	8809	42	several	several	JJ
cord-015021-pol2qm74	8809	43	approaches	approach	NNS
cord-015021-pol2qm74	8809	44	to	to	IN
cord-015021-pol2qm74	8809	45	restating	restate	VBG
cord-015021-pol2qm74	8809	46	thls	thls	NNP
cord-015021-pol2qm74	8809	47	function	function	NN
cord-015021-pol2qm74	8809	48	in	in	IN
cord-015021-pol2qm74	8809	49	a	a	DT
cord-015021-pol2qm74	8809	50	large	large	JJ
cord-015021-pol2qm74	8809	51	wound	wound	NN
cord-015021-pol2qm74	8809	52	,	,	,
cord-015021-pol2qm74	8809	53	'	'	''
cord-015021-pol2qm74	8810	1	l'nosc	l'nosc	NNP
cord-015021-pol2qm74	8810	2	i	i	NNP
cord-015021-pol2qm74	8811	1	~elud~	~elud~	NNP
cord-015021-pol2qm74	8811	2	tmmcdiete	tmmcdiete	JJ
cord-015021-pol2qm74	8811	3	long	long	JJ
cord-015021-pol2qm74	8811	4	term	term	NN
cord-015021-pol2qm74	8811	5	coverage	coverage	NN
cord-015021-pol2qm74	8811	6	,	,	,
cord-015021-pol2qm74	8811	7	short	short	JJ
cord-015021-pol2qm74	8811	8	t	t	NN
cord-015021-pol2qm74	8811	9	=	=	SYM
cord-015021-pol2qm74	8811	10	nn	nn	NNP
cord-015021-pol2qm74	8811	11	coverage	coverage	NN
cord-015021-pol2qm74	8811	12	,	,	,
cord-015021-pol2qm74	8811	13	uandtl	uandtl	NNP
cord-015021-pol2qm74	8811	14	~	~	NFP
cord-015021-pol2qm74	8811	15	el	el	NNP
cord-015021-pol2qm74	8811	16	coverage	coverage	NN
cord-015021-pol2qm74	8811	17	and	and	CC
cord-015021-pol2qm74	8811	18	compost=	compost=	NNP
cord-015021-pol2qm74	8811	19	dssu¢	dssu¢	NNP
cord-015021-pol2qm74	8811	20	coverage	coverage	NN
cord-015021-pol2qm74	8811	21	,	,	,
cord-015021-pol2qm74	8811	22	"	"	``
cord-015021-pol2qm74	8811	23	flssuo	flssuo	NNP
cord-015021-pol2qm74	8811	24	onglncrcd	onglncrcd	NNP
cord-015021-pol2qm74	8811	25	wound	wound	VBP
cord-015021-pol2qm74	8811	26	coverings	covering	NNS
cord-015021-pol2qm74	8811	27	that	that	WDT
cord-015021-pol2qm74	8811	28	meet	meet	VBP
cord-015021-pol2qm74	8811	29	those	those	DT
cord-015021-pol2qm74	8811	30	vaflous	vaflous	JJ
cord-015021-pol2qm74	8812	1	ne,.cds	ne,.cds	NNP
cord-015021-pol2qm74	8813	1	will	will	MD
cord-015021-pol2qm74	8813	2	he	-PRON-	PRP
cord-015021-pol2qm74	8813	3	r	r	VB
cord-015021-pol2qm74	8813	4	~	~	CD
cord-015021-pol2qm74	8813	5	vlowod	vlowod	NN
cord-015021-pol2qm74	8813	6	.	.	.
cord-015021-pol2qm74	8814	1	Cllni~:sl	Cllni~:sl	NNP
cord-015021-pol2qm74	8814	2	and	and	CC
cord-015021-pol2qm74	8814	3	experimental	experimental	JJ
cord-015021-pol2qm74	8814	4	d	d	NN
cord-015021-pol2qm74	8815	1	~la	~la	NNS
cord-015021-pol2qm74	8815	2	in	in	IN
cord-015021-pol2qm74	8815	3	venous	venous	JJ
cord-015021-pol2qm74	8815	4	ulcer	ulcer	NN
cord-015021-pol2qm74	8815	5	,	,	,
cord-015021-pol2qm74	8815	6	dlabctl¢	dlabctl¢	NNS
cord-015021-pol2qm74	8815	7	ulcers	ulcer	NNS
cord-015021-pol2qm74	8815	8	,	,	,
cord-015021-pol2qm74	8815	9	prossur~	prossur~	JJ
cord-015021-pol2qm74	8815	10	ulcers	ulcer	NNS
cord-015021-pol2qm74	8815	11	and	and	CC
cord-015021-pol2qm74	8815	12	bum	bum	NN
cord-015021-pol2qm74	8815	13	wounds	wound	NNS
cord-015021-pol2qm74	8815	14	wgJ	wgJ	NNS
cord-015021-pol2qm74	8815	15	be	be	VBP
cord-015021-pol2qm74	8815	16	mvlcw~	mvlcw~	FW
cord-015021-pol2qm74	8815	17	,	,	,
cord-015021-pol2qm74	8815	18	a~	a~	:
cord-015021-pol2qm74	8815	19	welt	welt	NN
cord-015021-pol2qm74	8815	20	as	as	IN
cord-015021-pol2qm74	8815	21	new	new	JJ
cord-015021-pol2qm74	8815	22	approacl~	approacl~	NNP
cord-015021-pol2qm74	8816	1	s	s	NNP
cord-015021-pol2qm74	8816	2	U~	U~	NNP
cord-015021-pol2qm74	8816	3	csrtilag¢	csrtilag¢	NN
cord-015021-pol2qm74	8816	4	,	,	,
cord-015021-pol2qm74	8816	5	bone	bone	NN
cord-015021-pol2qm74	8816	6	,	,	,
cord-015021-pol2qm74	8816	7	liver	liver	NN
cord-015021-pol2qm74	8816	8	and	and	CC
cord-015021-pol2qm74	8816	9	bone	bone	NN
cord-015021-pol2qm74	8816	10	marrow	marrow	NN
cord-015021-pol2qm74	8817	1	It	-PRON-	PRP
cord-015021-pol2qm74	8817	2	~	~	NFP
cord-015021-pol2qm74	8817	3	Suos	Suos	NNP
cord-015021-pol2qm74	8817	4	.	.	.
cord-015021-pol2qm74	8818	1	C	C	NNP
cord-015021-pol2qm74	8818	2	Oomplon	Oomplon	NNP
cord-015021-pol2qm74	8818	3	,	,	,
cord-015021-pol2qm74	8818	4	K	K	NNP
cord-015021-pol2qm74	8818	5	Nadirs	Nadirs	NNP
cord-015021-pol2qm74	8818	6	,	,	,
cord-015021-pol2qm74	8818	7	W	W	NNP
cord-015021-pol2qm74	8818	8	Press	Press	NNP
cord-015021-pol2qm74	8818	9	,	,	,
cord-015021-pol2qm74	8818	10	G	G	NNP
cord-015021-pol2qm74	8818	11	Wetland	Wetland	NNP
cord-015021-pol2qm74	8818	12	,	,	,
cord-015021-pol2qm74	8818	13	J	J	NNP
cord-015021-pol2qm74	8818	14	Fallen	Fallen	NNP
cord-015021-pol2qm74	8818	15	IV	IV	NNP
cord-015021-pol2qm74	8818	16	,	,	,
cord-015021-pol2qm74	8818	17	Shrtners	Shrtners	NNP
cord-015021-pol2qm74	8818	18	Burns	Burns	NNP
cord-015021-pol2qm74	8818	19	Institute	Institute	NNP
cord-015021-pol2qm74	8818	20	and	and	CC
cord-015021-pol2qm74	8818	21	Massachusetts	Massachusetts	NNP
cord-015021-pol2qm74	8818	22	General	General	NNP
cord-015021-pol2qm74	8818	23	Hospital	Hospital	NNP
cord-015021-pol2qm74	8818	24	,	,	,
cord-015021-pol2qm74	8818	25	Boston	Boston	NNP
cord-015021-pol2qm74	8818	26	,	,	,
cord-015021-pol2qm74	8818	27	Ma	Ma	NNP
cord-015021-pol2qm74	8818	28	~	~	NNP
cord-015021-pol2qm74	8818	29	schusetts	schusetts	NNP
cord-015021-pol2qm74	8818	30	,	,	,
cord-015021-pol2qm74	8818	31	USA	USA	NNP
cord-015021-pol2qm74	8819	1	The	the	DT
cord-015021-pol2qm74	8819	2	clinical	clinical	JJ
cord-015021-pol2qm74	8819	3	"	"	``
cord-015021-pol2qm74	8819	4	take	take	VB
cord-015021-pol2qm74	8819	5	"	"	''
cord-015021-pol2qm74	8819	6	rate	rate	NN
cord-015021-pol2qm74	8819	7	o	o	NN
cord-015021-pol2qm74	8819	8	?	?	.
cord-015021-pol2qm74	8819	9	cultured	cultured	JJ
cord-015021-pol2qm74	8819	10	epithelial	epithelial	JJ
cord-015021-pol2qm74	8819	11	autografts	autografts	NNP
cord-015021-pol2qm74	8819	12	(	(	-LRB-
cord-015021-pol2qm74	8819	13	CEA	CEA	NNP
cord-015021-pol2qm74	8819	14	)	)	-RRB-
cord-015021-pol2qm74	8819	15	has	have	VBZ
cord-015021-pol2qm74	8819	16	been	be	VBN
cord-015021-pol2qm74	8819	17	observed	observe	VBN
cord-015021-pol2qm74	8819	18	to	to	TO
cord-015021-pol2qm74	8819	19	Increase	increase	VB
cord-015021-pol2qm74	8819	20	with	with	IN
cord-015021-pol2qm74	8819	21	transplantation	transplantation	NN
cord-015021-pol2qm74	8819	22	to	to	IN
cord-015021-pol2qm74	8819	23	allodermls	allodermls	NNP
cord-015021-pol2qm74	8819	24	,	,	,
cord-015021-pol2qm74	8819	25	but	but	CC
cord-015021-pol2qm74	8819	26	the	the	DT
cord-015021-pol2qm74	8819	27	reasons	reason	NNS
cord-015021-pol2qm74	8819	28	for	for	IN
cord-015021-pol2qm74	8819	29	the	the	DT
cord-015021-pol2qm74	8819	30	improved	improved	JJ
cord-015021-pol2qm74	8819	31	clinical	clinical	JJ
cord-015021-pol2qm74	8819	32	performance	performance	NN
cord-015021-pol2qm74	8819	33	have	have	VBP
cord-015021-pol2qm74	8819	34	not	not	RB
cord-015021-pol2qm74	8819	35	yet	yet	RB
cord-015021-pol2qm74	8819	36	been	be	VBN
cord-015021-pol2qm74	8819	37	defined	define	VBN
cord-015021-pol2qm74	8819	38	.	.	.
cord-015021-pol2qm74	8820	1	The	the	DT
cord-015021-pol2qm74	8820	2	aim	aim	NN
cord-015021-pol2qm74	8820	3	of	of	IN
cord-015021-pol2qm74	8820	4	this	this	DT
cord-015021-pol2qm74	8820	5	study	study	NN
cord-015021-pol2qm74	8820	6	was	be	VBD
cord-015021-pol2qm74	8820	7	to	to	TO
cord-015021-pol2qm74	8820	8	determine	determine	VB
cord-015021-pol2qm74	8820	9	the	the	DT
cord-015021-pol2qm74	8820	10	biological	biological	JJ
cord-015021-pol2qm74	8820	11	impact	impact	NN
cord-015021-pol2qm74	8820	12	of	of	IN
cord-015021-pol2qm74	8820	13	normal	normal	JJ
cord-015021-pol2qm74	8820	14	human	human	JJ
cord-015021-pol2qm74	8820	15	dermis	dermis	NN
cord-015021-pol2qm74	8820	16	on	on	IN
cord-015021-pol2qm74	8820	17	CEA	CEA	NNP
cord-015021-pol2qm74	8820	18	differentiation	differentiation	NN
cord-015021-pol2qm74	8820	19	and	and	CC
cord-015021-pol2qm74	8820	20	maturation	maturation	NN
cord-015021-pol2qm74	8820	21	,	,	,
cord-015021-pol2qm74	8820	22	Biopsies	biopsy	NNS
cord-015021-pol2qm74	8820	23	of	of	IN
cord-015021-pol2qm74	8820	24	CEA	CEA	NNP
cord-015021-pol2qm74	8820	25	transplanted	transplant	VBD
cord-015021-pol2qm74	8820	26	to	to	IN
cord-015021-pol2qm74	8820	27	engrafted	engraft	VBN
cord-015021-pol2qm74	8820	28	and	and	CC
cord-015021-pol2qm74	8821	1	de	de	JJ
cord-015021-pol2qm74	8821	2	-	-	JJ
cord-015021-pol2qm74	8821	3	opldermlzed	opldermlzed	JJ
cord-015021-pol2qm74	8821	4	human	human	JJ
cord-015021-pol2qm74	8821	5	homograft	homograft	NN
cord-015021-pol2qm74	8821	6	dermis	dermis	NN
cord-015021-pol2qm74	8821	7	have	have	VBP
cord-015021-pol2qm74	8821	8	been	be	VBN
cord-015021-pol2qm74	8821	9	compared	compare	VBN
cord-015021-pol2qm74	8821	10	to	to	IN
cord-015021-pol2qm74	8821	11	Nopsles	Nopsles	NNP
cord-015021-pol2qm74	8821	12	of	of	IN
cord-015021-pol2qm74	8821	13	CEA	CEA	NNP
cord-015021-pol2qm74	8821	14	transplanted	transplant	VBD
cord-015021-pol2qm74	8821	15	to	to	IN
cord-015021-pol2qm74	8821	16	granulation	granulation	NN
cord-015021-pol2qm74	8821	17	tissue	tissue	NN
cord-015021-pol2qm74	8822	1	In	in	IN
cord-015021-pol2qm74	8822	2	tullthickness	tullthickness	NN
cord-015021-pol2qm74	8822	3	burn	burn	NN
cord-015021-pol2qm74	8822	4	wound	wind	VBD
cord-015021-pol2qm74	8822	5	beds	bed	NNS
cord-015021-pol2qm74	8822	6	on	on	IN
cord-015021-pol2qm74	8822	7	the	the	DT
cord-015021-pol2qm74	8822	8	same	same	JJ
cord-015021-pol2qm74	8822	9	patient	patient	NN
cord-015021-pol2qm74	8822	10	,	,	,
cord-015021-pol2qm74	8822	11	each	each	DT
cord-015021-pol2qm74	8822	12	patient	patient	NN
cord-015021-pol2qm74	8822	13	serving	serve	VBG
cord-015021-pol2qm74	8822	14	as	as	IN
cord-015021-pol2qm74	8822	15	hls	hls	NNP
cord-015021-pol2qm74	8822	16	or	or	CC
cord-015021-pol2qm74	8822	17	her	-PRON-	PRP$
cord-015021-pol2qm74	8822	18	own	own	JJ
cord-015021-pol2qm74	8822	19	control	control	NN
cord-015021-pol2qm74	8822	20	.	.	.
cord-015021-pol2qm74	8823	1	Paired	paired	JJ
cord-015021-pol2qm74	8823	2	test	test	NN
cord-015021-pol2qm74	8823	3	and	and	CC
cord-015021-pol2qm74	8823	4	control	control	NN
cord-015021-pol2qm74	8823	5	biopstes	biopste	NNS
cord-015021-pol2qm74	8823	6	from	from	IN
cord-015021-pol2qm74	8823	7	six	six	CD
cord-015021-pol2qm74	8823	8	patients	patient	NNS
cord-015021-pol2qm74	8823	9	have	have	VBP
cord-015021-pol2qm74	8823	10	acquired	acquire	VBN
cord-015021-pol2qm74	8823	11	from	from	IN
cord-015021-pol2qm74	8823	12	as	as	RB
cord-015021-pol2qm74	8823	13	early	early	RB
cord-015021-pol2qm74	8823	14	as	as	IN
cord-015021-pol2qm74	8823	15	one	one	CD
cord-015021-pol2qm74	8823	16	week	week	NN
cord-015021-pol2qm74	8823	17	postgrafting	postgrafting	NN
cord-015021-pol2qm74	8823	18	to	to	IN
cord-015021-pol2qm74	8823	19	as	as	RB
cord-015021-pol2qm74	8823	20	late	late	JJ
cord-015021-pol2qm74	8823	21	as	as	IN
cord-015021-pol2qm74	8823	22	3	3	CD
cord-015021-pol2qm74	8823	23	years	year	NNS
cord-015021-pol2qm74	8823	24	postgrafting	postgrafting	JJ
cord-015021-pol2qm74	8823	25	(	(	-LRB-
cord-015021-pol2qm74	8823	26	one	one	CD
cord-015021-pol2qm74	8823	27	patient	patient	NN
cord-015021-pol2qm74	8823	28	)	)	-RRB-
cord-015021-pol2qm74	8823	29	and	and	CC
cord-015021-pol2qm74	8823	30	analyzed	analyze	VBN
cord-015021-pol2qm74	8823	31	histopathologlcally	histopathologlcally	RB
cord-015021-pol2qm74	8823	32	,	,	,
cord-015021-pol2qm74	8823	33	ultrastructurally	ultrastructurally	NN
cord-015021-pol2qm74	8823	34	and	and	CC
cord-015021-pol2qm74	8823	35	immunoh[stochemloally	immunoh[stochemloally	RB
cord-015021-pol2qm74	8823	36	,	,	,
cord-015021-pol2qm74	8823	37	Results	result	NNS
cord-015021-pol2qm74	8823	38	demonstrate	demonstrate	VBP
cord-015021-pol2qm74	8823	39	more	more	RBR
cord-015021-pol2qm74	8823	40	rapid	rapid	JJ
cord-015021-pol2qm74	8823	41	normalization	normalization	NN
cord-015021-pol2qm74	8823	42	of	of	IN
cord-015021-pol2qm74	8823	43	differentiation	differentiation	NN
cord-015021-pol2qm74	8823	44	markers	marker	NNS
cord-015021-pol2qm74	8823	45	(	(	-LRB-
cord-015021-pol2qm74	8823	46	e	e	NN
cord-015021-pol2qm74	8823	47	,	,	,
cord-015021-pol2qm74	8823	48	g	g	NNP
cord-015021-pol2qm74	8823	49	.	.	NNP
cord-015021-pol2qm74	8823	50	,	,	,
cord-015021-pol2qm74	8823	51	Involucfln	Involucfln	NNP
cord-015021-pol2qm74	8823	52	,	,	,
cord-015021-pol2qm74	8823	53	fllaggrln	fllaggrln	NNP
cord-015021-pol2qm74	8823	54	,	,	,
cord-015021-pol2qm74	8823	55	cytokeratln	cytokeratln	NNP
cord-015021-pol2qm74	8823	56	profiles	profile	NNS
cord-015021-pol2qm74	8823	57	)	)	-RRB-
cord-015021-pol2qm74	8823	58	in	in	IN
cord-015021-pol2qm74	8823	59	the	the	DT
cord-015021-pol2qm74	8823	60	CEA	CEA	NNP
cord-015021-pol2qm74	8823	61	transplanted	transplant	VBD
cord-015021-pol2qm74	8823	62	to	to	IN
cord-015021-pol2qm74	8823	63	allodermls	allodermls	NNP
cord-015021-pol2qm74	8823	64	compared	compare	VBN
cord-015021-pol2qm74	8823	65	to	to	IN
cord-015021-pol2qm74	8823	66	their	-PRON-	PRP$
cord-015021-pol2qm74	8823	67	corresponding	corresponding	JJ
cord-015021-pol2qm74	8823	68	controls	control	NNS
cord-015021-pol2qm74	8823	69	by	by	IN
cord-015021-pol2qm74	8823	70	in	in	IN
cord-015021-pol2qm74	8823	71	all	all	DT
cord-015021-pol2qm74	8823	72	patients	patient	NNS
cord-015021-pol2qm74	8823	73	,	,	,
cord-015021-pol2qm74	8823	74	The	the	DT
cord-015021-pol2qm74	8823	75	proliferation	proliferation	NN
cord-015021-pol2qm74	8823	76	rate	rate	NN
cord-015021-pol2qm74	8823	77	within	within	IN
cord-015021-pol2qm74	8823	78	the	the	DT
cord-015021-pol2qm74	8823	79	basal	basal	NN
cord-015021-pol2qm74	8823	80	layer	layer	NN
cord-015021-pol2qm74	8823	81	ot	ot	VBP
cord-015021-pol2qm74	8823	82	the	the	DT
cord-015021-pol2qm74	8823	83	epidermis	epidermis	NN
cord-015021-pol2qm74	8823	84	as	as	IN
cord-015021-pol2qm74	8823	85	determined	determine	VBN
cord-015021-pol2qm74	8823	86	by	by	IN
cord-015021-pol2qm74	8824	1	Ki-67	Ki-67	.
cord-015021-pol2qm74	8825	1	(	(	-LRB-
cord-015021-pol2qm74	8825	2	proliferation	proliferation	NN
cord-015021-pol2qm74	8825	3	-	-	HYPH
cord-015021-pol2qm74	8825	4	associated	associate	VBN
cord-015021-pol2qm74	8825	5	antigen	antigen	NN
cord-015021-pol2qm74	8825	6	)	)	-RRB-
cord-015021-pol2qm74	8825	7	Is	be	VBZ
cord-015021-pol2qm74	8825	8	seen	see	VBN
cord-015021-pol2qm74	8825	9	to	to	TO
cord-015021-pol2qm74	8825	10	norh	norh	VB
cord-015021-pol2qm74	8825	11	~	~	NFP
cord-015021-pol2qm74	8825	12	altze	altze	NNPS
cord-015021-pol2qm74	8825	13	more	more	RBR
cord-015021-pol2qm74	8825	14	quickly	quickly	RB
cord-015021-pol2qm74	8826	1	In	in	IN
cord-015021-pol2qm74	8826	2	the	the	DT
cord-015021-pol2qm74	8826	3	CEA	CEA	NNP
cord-015021-pol2qm74	8826	4	transplanted	transplant	VBD
cord-015021-pol2qm74	8826	5	to	to	IN
cord-015021-pol2qm74	8826	6	allodermls	allodermls	NNP
cord-015021-pol2qm74	8826	7	in	in	IN
cord-015021-pol2qm74	8826	8	every	every	DT
cord-015021-pol2qm74	8826	9	case	case	NN
cord-015021-pol2qm74	8826	10	,	,	,
cord-015021-pol2qm74	8826	11	Persistence	Persistence	NNP
cord-015021-pol2qm74	8826	12	of	of	IN
cord-015021-pol2qm74	8826	13	allodermal	allodermal	JJ
cord-015021-pol2qm74	8826	14	matrix	matrix	NN
cord-015021-pol2qm74	8826	15	can	can	MD
cord-015021-pol2qm74	8826	16	be	be	VB
cord-015021-pol2qm74	8826	17	doOumented	dooumente	VBN
cord-015021-pol2qm74	8826	18	In	in	IN
cord-015021-pol2qm74	8826	19	all	all	DT
cord-015021-pol2qm74	8826	20	patients	patient	NNS
cord-015021-pol2qm74	8826	21	by	by	IN
cord-015021-pol2qm74	8826	22	elastic	elastic	JJ
cord-015021-pol2qm74	8826	23	tlssue	tlssue	RB
cord-015021-pol2qm74	8826	24	-	-	HYPH
cord-015021-pol2qm74	8826	25	trichrome	trichrome	JJ
cord-015021-pol2qm74	8826	26	stain	stain	NN
cord-015021-pol2qm74	8826	27	,	,	,
cord-015021-pol2qm74	8826	28	allowing	allow	VBG
cord-015021-pol2qm74	8826	29	visualization	visualization	NN
cord-015021-pol2qm74	8826	30	of	of	IN
cord-015021-pol2qm74	8826	31	the	the	DT
cord-015021-pol2qm74	8826	32	dermal	dermal	JJ
cord-015021-pol2qm74	8826	33	elastin	elastin	NN
cord-015021-pol2qm74	8826	34	network	network	NN
cord-015021-pol2qm74	8826	35	.	.	.
cord-015021-pol2qm74	8827	1	The	the	DT
cord-015021-pol2qm74	8827	2	popu;atlon	popu;atlon	NN
cord-015021-pol2qm74	8827	3	densities	density	NNS
cord-015021-pol2qm74	8827	4	ot	ot	VBP
cord-015021-pol2qm74	8828	1	Intraepldarmal	Intraepldarmal	NNP
cord-015021-pol2qm74	8828	2	Langerhans	Langerhans	NNP
cord-015021-pol2qm74	8828	3	cells	cell	NNS
cord-015021-pol2qm74	8828	4	are	be	VBP
cord-015021-pol2qm74	8828	5	conslstently	conslstently	RB
cord-015021-pol2qm74	8828	6	and	and	CC
cord-015021-pol2qm74	8828	7	signlflcantly	signlflcantly	RB
cord-015021-pol2qm74	8828	8	higher	high	JJR
cord-015021-pol2qm74	8829	1	In	in	IN
cord-015021-pol2qm74	8829	2	CEA	CEA	NNP
cord-015021-pol2qm74	8829	3	transplanted	transplant	VBD
cord-015021-pol2qm74	8829	4	to	to	IN
cord-015021-pol2qm74	8829	5	,	,	,
cord-015021-pol2qm74	8829	6	allodermls	allodermls	NNP
cord-015021-pol2qm74	8829	7	,	,	,
cord-015021-pol2qm74	8829	8	possibly	possibly	RB
cord-015021-pol2qm74	8829	9	reflectlng	reflectlng	VB
cord-015021-pol2qm74	8829	10	an	an	DT
cord-015021-pol2qm74	8829	11	Immunologlcal	Immunologlcal	NNP
cord-015021-pol2qm74	8829	12	reaction	reaction	NN
cord-015021-pol2qm74	8829	13	to	to	IN
cord-015021-pol2qm74	8829	14	the	the	DT
cord-015021-pol2qm74	8829	15	underlying	underlying	JJ
cord-015021-pol2qm74	8829	16	allogenlc	allogenlc	JJ
cord-015021-pol2qm74	8829	17	tissue	tissue	NN
cord-015021-pol2qm74	8829	18	.	.	.
cord-015021-pol2qm74	8830	1	Overall	overall	RB
cord-015021-pol2qm74	8830	2	,	,	,
cord-015021-pol2qm74	8830	3	these	these	DT
cord-015021-pol2qm74	8830	4	preliminary	preliminary	JJ
cord-015021-pol2qm74	8830	5	results	result	NNS
cord-015021-pol2qm74	8830	6	indicate	indicate	VBP
cord-015021-pol2qm74	8830	7	that	that	IN
cord-015021-pol2qm74	8830	8	transplantation	transplantation	NN
cord-015021-pol2qm74	8830	9	to	to	IN
cord-015021-pol2qm74	8830	10	a	a	DT
cord-015021-pol2qm74	8830	11	normal	normal	JJ
cord-015021-pol2qm74	8830	12	human	human	JJ
cord-015021-pol2qm74	8830	13	dermal	dermal	NN
cord-015021-pol2qm74	8830	14	matrix	matrix	NN
cord-015021-pol2qm74	8830	15	accelerates	accelerate	VBZ
cord-015021-pol2qm74	8830	16	the	the	DT
cord-015021-pol2qm74	8830	17	maturation	maturation	NN
cord-015021-pol2qm74	8830	18	of	of	IN
cord-015021-pol2qm74	8830	19	CEA	CEA	NNP
cord-015021-pol2qm74	8830	20	-	-	HYPH
cord-015021-pol2qm74	8830	21	deflved	deflved	NNP
cord-015021-pol2qm74	8830	22	epidermis	epidermis	NN
cord-015021-pol2qm74	8830	23	,	,	,
cord-015021-pol2qm74	8830	24	Wound	Wound	NNP
cord-015021-pol2qm74	8830	25	closure	closure	NN
cord-015021-pol2qm74	8830	26	continues	continue	VBZ
cord-015021-pol2qm74	8830	27	to	to	TO
cord-015021-pol2qm74	8830	28	be	be	VB
cord-015021-pol2qm74	8830	29	a	a	DT
cord-015021-pol2qm74	8830	30	major	major	JJ
cord-015021-pol2qm74	8830	31	problem	problem	NN
cord-015021-pol2qm74	8830	32	in	in	IN
cord-015021-pol2qm74	8830	33	patients	patient	NNS
cord-015021-pol2qm74	8830	34	who	who	WP
cord-015021-pol2qm74	8830	35	have	have	VBP
cord-015021-pol2qm74	8830	36	sustained	sustain	VBN
cord-015021-pol2qm74	8830	37	a	a	DT
cord-015021-pol2qm74	8830	38	major	major	JJ
cord-015021-pol2qm74	8830	39	thermal	thermal	JJ
cord-015021-pol2qm74	8830	40	InJury	InJury	NNP
cord-015021-pol2qm74	8830	41	,	,	,
cord-015021-pol2qm74	8830	42	Cultured	cultured	JJ
cord-015021-pol2qm74	8830	43	epidermal	epidermal	JJ
cord-015021-pol2qm74	8830	44	autografts	autograft	NNS
cord-015021-pol2qm74	8830	45	(	(	-LRB-
cord-015021-pol2qm74	8830	46	CEA	CEA	NNP
cord-015021-pol2qm74	8830	47	)	)	-RRB-
cord-015021-pol2qm74	8830	48	have	have	VBP
cord-015021-pol2qm74	8830	49	been	be	VBN
cord-015021-pol2qm74	8830	50	utilized	utilize	VBN
cord-015021-pol2qm74	8830	51	extensively	extensively	RB
cord-015021-pol2qm74	8830	52	since	since	IN
cord-015021-pol2qm74	8830	53	1984	1984	CD
cord-015021-pol2qm74	8830	54	when	when	WRB
cord-015021-pol2qm74	8830	55	Galllco	Galllco	NNP
cord-015021-pol2qm74	8830	56	et	et	NNP
cord-015021-pol2qm74	8830	57	el	el	NNP
cord-015021-pol2qm74	8830	58	reported	report	VBD
cord-015021-pol2qm74	8830	59	theh'use	theh'use	CD
cord-015021-pol2qm74	8831	1	In	in	IN
cord-015021-pol2qm74	8831	2	two	two	CD
cord-015021-pol2qm74	8831	3	brothers	brother	NNS
cord-015021-pol2qm74	8831	4	with	with	IN
cord-015021-pol2qm74	8831	5	greater	great	JJR
cord-015021-pol2qm74	8831	6	than	than	IN
cord-015021-pol2qm74	8831	7	90	90	CD
cord-015021-pol2qm74	8831	8	%	%	NN
cord-015021-pol2qm74	8831	9	total	total	JJ
cord-015021-pol2qm74	8831	10	body	body	NN
cord-015021-pol2qm74	8831	11	surface	surface	NN
cord-015021-pol2qm74	8831	12	area	area	NN
cord-015021-pol2qm74	8831	13	burn	burn	VB
cord-015021-pol2qm74	8831	14	.	.	.
cord-015021-pol2qm74	8832	1	Unfortunately	unfortunately	RB
cord-015021-pol2qm74	8832	2	,	,	,
cord-015021-pol2qm74	8832	3	CEA	CEA	NNP
cord-015021-pol2qm74	8832	4	take	take	VB
cord-015021-pol2qm74	8832	5	rate	rate	NN
cord-015021-pol2qm74	8832	6	varies	vary	VBZ
cord-015021-pol2qm74	8832	7	widely	widely	RB
cord-015021-pol2qm74	8832	8	and	and	CC
cord-015021-pol2qm74	8832	9	the	the	DT
cord-015021-pol2qm74	8832	10	resultant	resultant	JJ
cord-015021-pol2qm74	8832	11	skin	skin	NN
cord-015021-pol2qm74	8832	12	coverage	coverage	NN
cord-015021-pol2qm74	8832	13	Is	be	VBZ
cord-015021-pol2qm74	8832	14	often	often	RB
cord-015021-pol2qm74	8832	15	fragile	fragile	JJ
cord-015021-pol2qm74	8832	16	and	and	CC
cord-015021-pol2qm74	8832	17	the	the	DT
cord-015021-pol2qm74	8832	18	cosmetic	cosmetic	JJ
cord-015021-pol2qm74	8832	19	results	result	NNS
cord-015021-pol2qm74	8832	20	are	be	VBP
cord-015021-pol2qm74	8832	21	less	less	JJR
cord-015021-pol2qm74	8832	22	than	than	IN
cord-015021-pol2qm74	8832	23	optimal	optimal	JJ
cord-015021-pol2qm74	8833	1	However	however	RB
cord-015021-pol2qm74	8833	2	the	the	DT
cord-015021-pol2qm74	8833	3	overall	overall	JJ
cord-015021-pol2qm74	8833	4	take	take	NN
cord-015021-pol2qm74	8834	1	rate	rate	NN
cord-015021-pol2qm74	8834	2	and	and	CC
cord-015021-pol2qm74	8834	3	durability	durability	NN
cord-015021-pol2qm74	8834	4	of	of	IN
cord-015021-pol2qm74	8834	5	the	the	DT
cord-015021-pol2qm74	8834	6	coveraSe	coveraSe	NNP
cord-015021-pol2qm74	8834	7	can	can	MD
cord-015021-pol2qm74	8834	8	be	be	VB
cord-015021-pol2qm74	8834	9	markedly	markedly	RB
cord-015021-pol2qm74	8834	10	Improved	improve	VBN
cord-015021-pol2qm74	8834	11	by	by	IN
cord-015021-pol2qm74	8834	12	using	use	VBG
cord-015021-pol2qm74	8834	13	nn	nn	NNP
cord-015021-pol2qm74	8834	14	allodermls	allodermls	NNP
cord-015021-pol2qm74	8834	15	base	base	NN
cord-015021-pol2qm74	8834	16	as	as	IN
cord-015021-pol2qm74	8834	17	the	the	DT
cord-015021-pol2qm74	8834	18	recipient	recipient	NN
cord-015021-pol2qm74	8834	19	bed	bed	NN
cord-015021-pol2qm74	8834	20	.	.	.
cord-015021-pol2qm74	8835	1	A	a	DT
cord-015021-pol2qm74	8835	2	review	review	NN
cord-015021-pol2qm74	8835	3	of	of	IN
cord-015021-pol2qm74	8835	4	CEA	CEA	NNP
cord-015021-pol2qm74	8835	5	applications	application	NNS
cord-015021-pol2qm74	8835	6	performed	perform	VBN
cord-015021-pol2qm74	8835	7	by	by	IN
cord-015021-pol2qm74	8835	8	physicians	physician	NNS
cord-015021-pol2qm74	8835	9	using	use	VBG
cord-015021-pol2qm74	8835	10	cultured	cultured	JJ
cord-015021-pol2qm74	8835	11	outologens	outologens	JJ
cord-015021-pol2qm74	8835	12	epithelium	epithelium	NN
cord-015021-pol2qm74	8835	13	obtained	obtain	VBN
cord-015021-pol2qm74	8835	14	from	from	IN
cord-015021-pol2qm74	8835	15	Blusurfaoe	Blusurfaoe	NNP
cord-015021-pol2qm74	8835	16	Teclmology	Teclmology	NNP
cord-015021-pol2qm74	8835	17	,	,	,
cord-015021-pol2qm74	8835	18	Inc.	Inc.	NNP
cord-015021-pol2qm74	8835	19	shows	show	VBZ
cord-015021-pol2qm74	8835	20	a	a	DT
cord-015021-pol2qm74	8835	21	marked	marked	JJ
cord-015021-pol2qm74	8835	22	discrepancy	discrepancy	NN
cord-015021-pol2qm74	8835	23	in	in	IN
cord-015021-pol2qm74	8835	24	the	the	DT
cord-015021-pol2qm74	8835	25	results	result	NNS
cord-015021-pol2qm74	8835	26	obtained	obtain	VBN
cord-015021-pol2qm74	8835	27	utilizing	utilize	VBG
cord-015021-pol2qm74	8835	28	different	different	JJ
cord-015021-pol2qm74	8835	29	methods	method	NNS
cord-015021-pol2qm74	8835	30	of	of	IN
cord-015021-pol2qm74	8835	31	wound	wound	JJ
cord-015021-pol2qm74	8835	32	bed	bed	NN
cord-015021-pol2qm74	8835	33	preparation	preparation	NN
cord-015021-pol2qm74	8835	34	.	.	.
cord-015021-pol2qm74	8836	1	TGF	TGF	NNP
cord-015021-pol2qm74	8836	2	-	-	HYPH
cord-015021-pol2qm74	8836	3	B	B	NNP
cord-015021-pol2qm74	8836	4	is	be	VBZ
cord-015021-pol2qm74	8836	5	an	an	DT
cord-015021-pol2qm74	8836	6	important	important	JJ
cord-015021-pol2qm74	8836	7	modulator	modulator	NN
cord-015021-pol2qm74	8836	8	coordinating	coordinate	VBG
cord-015021-pol2qm74	8836	9	complex	complex	JJ
cord-015021-pol2qm74	8836	10	physiological	physiological	JJ
cord-015021-pol2qm74	8836	11	events	event	NNS
cord-015021-pol2qm74	8836	12	associated	associate	VBN
cord-015021-pol2qm74	8836	13	with	with	IN
cord-015021-pol2qm74	8836	14	growth	growth	NN
cord-015021-pol2qm74	8836	15	and	and	CC
cord-015021-pol2qm74	8836	16	development	development	NN
cord-015021-pol2qm74	8836	17	.	.	.
cord-015021-pol2qm74	8837	1	It	-PRON-	PRP
cord-015021-pol2qm74	8837	2	is	be	VBZ
cord-015021-pol2qm74	8837	3	assumed	assume	VBN
cord-015021-pol2qm74	8837	4	that	that	IN
cord-015021-pol2qm74	8837	5	TGF	TGF	NNP
cord-015021-pol2qm74	8837	6	-	-	HYPH
cord-015021-pol2qm74	8837	7	B	B	NNP
cord-015021-pol2qm74	8837	8	is	be	VBZ
cord-015021-pol2qm74	8837	9	also	also	RB
cord-015021-pol2qm74	8837	10	involved	involve	VBN
cord-015021-pol2qm74	8837	11	in	in	IN
cord-015021-pol2qm74	8837	12	the	the	DT
cord-015021-pol2qm74	8837	13	well	well	RB
cord-015021-pol2qm74	8837	14	-	-	HYPH
cord-015021-pol2qm74	8837	15	coordinated	coordinate	VBN
cord-015021-pol2qm74	8837	16	process	process	NN
cord-015021-pol2qm74	8837	17	of	of	IN
cord-015021-pol2qm74	8837	18	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	8837	19	wound	wound	NN
cord-015021-pol2qm74	8837	20	healing	healing	NN
cord-015021-pol2qm74	8837	21	by	by	IN
cord-015021-pol2qm74	8837	22	regulating	regulate	VBG
cord-015021-pol2qm74	8837	23	proliferation	proliferation	NN
cord-015021-pol2qm74	8837	24	,	,	,
cord-015021-pol2qm74	8837	25	differentiation	differentiation	NN
cord-015021-pol2qm74	8837	26	,	,	,
cord-015021-pol2qm74	8837	27	chemotaxis	chemotaxis	NN
cord-015021-pol2qm74	8837	28	and	and	CC
cord-015021-pol2qm74	8837	29	matrix	matrix	NN
cord-015021-pol2qm74	8837	30	deposition	deposition	NN
cord-015021-pol2qm74	8837	31	.	.	.
cord-015021-pol2qm74	8838	1	The	the	DT
cord-015021-pol2qm74	8838	2	purpose	purpose	NN
cord-015021-pol2qm74	8838	3	of	of	IN
cord-015021-pol2qm74	8838	4	our	-PRON-	PRP$
cord-015021-pol2qm74	8838	5	study	study	NN
cord-015021-pol2qm74	8838	6	was	be	VBD
cord-015021-pol2qm74	8838	7	to	to	TO
cord-015021-pol2qm74	8838	8	analyze	analyze	VB
cord-015021-pol2qm74	8838	9	the	the	DT
cord-015021-pol2qm74	8838	10	spatial	spatial	JJ
cord-015021-pol2qm74	8838	11	and	and	CC
cord-015021-pol2qm74	8838	12	temporal	temporal	JJ
cord-015021-pol2qm74	8838	13	pattern	pattern	NN
cord-015021-pol2qm74	8838	14	of	of	IN
cord-015021-pol2qm74	8838	15	TGF	TGF	NNP
cord-015021-pol2qm74	8838	16	-	-	HYPH
cord-015021-pol2qm74	8838	17	B	b	NN
cord-015021-pol2qm74	8838	18	expression	expression	NN
cord-015021-pol2qm74	8838	19	during	during	IN
cord-015021-pol2qm74	8838	20	granulation	granulation	NN
cord-015021-pol2qm74	8838	21	tissue	tissue	NN
cord-015021-pol2qm74	8838	22	formation	formation	NN
cord-015021-pol2qm74	8838	23	in	in	IN
cord-015021-pol2qm74	8838	24	patients	patient	NNS
cord-015021-pol2qm74	8838	25	with	with	IN
cord-015021-pol2qm74	8838	26	accidanutl	accidanutl	NNP
cord-015021-pol2qm74	8838	27	surgical	surgical	JJ
cord-015021-pol2qm74	8838	28	trauma	trauma	NN
cord-015021-pol2qm74	8839	1	(	(	-LRB-
cord-015021-pol2qm74	8839	2	monotraumata	monotraumata	NNP
cord-015021-pol2qm74	8839	3	mid	mid	NNP
cord-015021-pol2qm74	8839	4	polytraumata	polytraumata	NNP
cord-015021-pol2qm74	8839	5	)	)	-RRB-
cord-015021-pol2qm74	8839	6	and	and	CC
cord-015021-pol2qm74	8839	7	bum	bum	JJ
cord-015021-pol2qm74	8839	8	wounds	wound	NNS
cord-015021-pol2qm74	8839	9	.	.	.
cord-015021-pol2qm74	8840	1	After	after	IN
cord-015021-pol2qm74	8840	2	debridement	debridement	NN
cord-015021-pol2qm74	8840	3	(	(	-LRB-
cord-015021-pol2qm74	8840	4	day	day	NN
cord-015021-pol2qm74	8840	5	0	0	CD
cord-015021-pol2qm74	8840	6	)	)	-RRB-
cord-015021-pol2qm74	8840	7	,	,	,
cord-015021-pol2qm74	8840	8	the	the	DT
cord-015021-pol2qm74	8840	9	full	full	JJ
cord-015021-pol2qm74	8840	10	thickness	thickness	NN
cord-015021-pol2qm74	8840	11	wounds	wound	NNS
cord-015021-pol2qm74	8840	12	were	be	VBD
cord-015021-pol2qm74	8840	13	covered	cover	VBN
cord-015021-pol2qm74	8840	14	with	with	IN
cord-015021-pol2qm74	8840	15	Epigard	Epigard	NNP
cord-015021-pol2qm74	8840	16	,	,	,
cord-015021-pol2qm74	8840	17	a	a	DT
cord-015021-pol2qm74	8840	18	synthetic	synthetic	JJ
cord-015021-pol2qm74	8840	19	dressing	dressing	NN
cord-015021-pol2qm74	8840	20	until	until	IN
cord-015021-pol2qm74	8840	21	day	day	NN
cord-015021-pol2qm74	8840	22	10	10	CD
cord-015021-pol2qm74	8840	23	.	.	.
cord-015021-pol2qm74	8841	1	After	after	IN
cord-015021-pol2qm74	8841	2	this	this	DT
cord-015021-pol2qm74	8841	3	time	time	NN
cord-015021-pol2qm74	8841	4	the	the	DT
cord-015021-pol2qm74	8841	5	granulated	granulated	JJ
cord-015021-pol2qm74	8841	6	wounds	wound	NNS
cord-015021-pol2qm74	8841	7	were	be	VBD
cord-015021-pol2qm74	8841	8	closed	close	VBN
cord-015021-pol2qm74	8841	9	by	by	IN
cord-015021-pol2qm74	8841	10	transplantation	transplantation	NN
cord-015021-pol2qm74	8841	11	of	of	IN
cord-015021-pol2qm74	8841	12	mesh	mesh	NN
cord-015021-pol2qm74	8841	13	graft	graft	NN
cord-015021-pol2qm74	8841	14	.	.	.
cord-015021-pol2qm74	8842	1	Biopsies	biopsy	NNS
cord-015021-pol2qm74	8842	2	of	of	IN
cord-015021-pol2qm74	8842	3	the	the	DT
cord-015021-pol2qm74	8842	4	wound	wound	NN
cord-015021-pol2qm74	8842	5	center	center	NN
cord-015021-pol2qm74	8842	6	were	be	VBD
cord-015021-pol2qm74	8842	7	taken	take	VBN
cord-015021-pol2qm74	8842	8	from	from	IN
cord-015021-pol2qm74	8842	9	30	30	CD
cord-015021-pol2qm74	8842	10	patients	patient	NNS
cord-015021-pol2qm74	8842	11	at	at	IN
cord-015021-pol2qm74	8842	12	the	the	DT
cord-015021-pol2qm74	8842	13	beginning	beginning	NN
cord-015021-pol2qm74	8842	14	of	of	IN
cord-015021-pol2qm74	8842	15	surgical	surgical	JJ
cord-015021-pol2qm74	8842	16	treatment	treatment	NN
cord-015021-pol2qm74	8842	17	(	(	-LRB-
cord-015021-pol2qm74	8842	18	day	day	NN
cord-015021-pol2qm74	8842	19	0	0	CD
cord-015021-pol2qm74	8842	20	)	)	-RRB-
cord-015021-pol2qm74	8842	21	and	and	CC
cord-015021-pol2qm74	8842	22	after	after	IN
cord-015021-pol2qm74	8842	23	3	3	CD
cord-015021-pol2qm74	8842	24	,	,	,
cord-015021-pol2qm74	8842	25	6	6	CD
cord-015021-pol2qm74	8842	26	,	,	,
cord-015021-pol2qm74	8842	27	and	and	CC
cord-015021-pol2qm74	8842	28	10	10	CD
cord-015021-pol2qm74	8842	29	days	day	NNS
cord-015021-pol2qm74	8842	30	.	.	.
cord-015021-pol2qm74	8843	1	Cryosections	cryosection	NNS
cord-015021-pol2qm74	8843	2	were	be	VBD
cord-015021-pol2qm74	8843	3	stained	stain	VBN
cord-015021-pol2qm74	8843	4	with	with	IN
cord-015021-pol2qm74	8843	5	antibodies	antibody	NNS
cord-015021-pol2qm74	8843	6	against	against	IN
cord-015021-pol2qm74	8843	7	TGF	TGF	NNP
cord-015021-pol2qm74	8843	8	-	-	HYPH
cord-015021-pol2qm74	8843	9	fi	fi	NNP
cord-015021-pol2qm74	8843	10	s	s	NNP
cord-015021-pol2qm74	8843	11	using	use	VBG
cord-015021-pol2qm74	8843	12	the	the	DT
cord-015021-pol2qm74	8843	13	APAAP	APAAP	NNP
cord-015021-pol2qm74	8843	14	technique	technique	NN
cord-015021-pol2qm74	8843	15	and	and	CC
cord-015021-pol2qm74	8843	16	-for	-for	HYPH
cord-015021-pol2qm74	8843	17	standard	standard	JJ
cord-015021-pol2qm74	8843	18	histology	histology	NN
cord-015021-pol2qm74	8843	19	-with	-with	:
cord-015021-pol2qm74	8843	20	Hematoxylin	Hematoxylin	NNP
cord-015021-pol2qm74	8843	21	-	-	HYPH
cord-015021-pol2qm74	8843	22	Eosin	Eosin	NNP
cord-015021-pol2qm74	8843	23	.	.	.
cord-015021-pol2qm74	8844	1	For	for	IN
cord-015021-pol2qm74	8844	2	identification	identification	NN
cord-015021-pol2qm74	8844	3	of	of	IN
cord-015021-pol2qm74	8844	4	the	the	DT
cord-015021-pol2qm74	8844	5	cell	cell	NN
cord-015021-pol2qm74	8844	6	type	type	NN
cord-015021-pol2qm74	8844	7	expressing	express	VBG
cord-015021-pol2qm74	8844	8	TGF-6	TGF-6	NNP
cord-015021-pol2qm74	8844	9	,	,	,
cord-015021-pol2qm74	8844	10	double	double	JJ
cord-015021-pol2qm74	8844	11	staining	staining	NN
cord-015021-pol2qm74	8844	12	immunofluorescence	immunofluorescence	NN
cord-015021-pol2qm74	8844	13	experiments	experiment	NNS
cord-015021-pol2qm74	8844	14	were	be	VBD
cord-015021-pol2qm74	8844	15	conducted	conduct	VBN
cord-015021-pol2qm74	8844	16	using	use	VBG
cord-015021-pol2qm74	8844	17	antibodies	antibody	NNS
cord-015021-pol2qm74	8844	18	specific	specific	JJ
cord-015021-pol2qm74	8844	19	for	for	IN
cord-015021-pol2qm74	8844	20	monocytes	monocyte	NNS
cord-015021-pol2qm74	8844	21	/	/	SYM
cord-015021-pol2qm74	8844	22	macrophages	macrophage	NNS
cord-015021-pol2qm74	8844	23	,	,	,
cord-015021-pol2qm74	8844	24	polymorphoanclear	polymorphoanclear	NNP
cord-015021-pol2qm74	8844	25	neutropkils	neutropkil	NNS
cord-015021-pol2qm74	8844	26	and	and	CC
cord-015021-pol2qm74	8844	27	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	8844	28	.	.	.
cord-015021-pol2qm74	8845	1	The	the	DT
cord-015021-pol2qm74	8845	2	results	result	NNS
cord-015021-pol2qm74	8845	3	showed	show	VBD
cord-015021-pol2qm74	8845	4	a	a	DT
cord-015021-pol2qm74	8845	5	characteristic	characteristic	JJ
cord-015021-pol2qm74	8845	6	pattern	pattern	NN
cord-015021-pol2qm74	8845	7	of	of	IN
cord-015021-pol2qm74	8845	8	TGF	TGF	NNP
cord-015021-pol2qm74	8845	9	-	-	HYPH
cord-015021-pol2qm74	8845	10	t~	t~	CD
cord-015021-pol2qm74	8845	11	distribution	distribution	NN
cord-015021-pol2qm74	8845	12	during	during	IN
cord-015021-pol2qm74	8845	13	wound	wound	NN
cord-015021-pol2qm74	8845	14	development	development	NN
cord-015021-pol2qm74	8845	15	.	.	.
cord-015021-pol2qm74	8846	1	TGF	TGF	NNP
cord-015021-pol2qm74	8846	2	-	-	HYPH
cord-015021-pol2qm74	8846	3	fi	fi	NN
cord-015021-pol2qm74	8846	4	appearence	appearence	NN
cord-015021-pol2qm74	8846	5	was	be	VBD
cord-015021-pol2qm74	8846	6	mainly	mainly	RB
cord-015021-pol2qm74	8846	7	cell	cell	NN
cord-015021-pol2qm74	8846	8	-	-	HYPH
cord-015021-pol2qm74	8846	9	associated	associate	VBN
cord-015021-pol2qm74	8846	10	znd	znd	NN
cord-015021-pol2qm74	8847	1	the	the	DT
cord-015021-pol2qm74	8847	2	absolute	absolute	JJ
cord-015021-pol2qm74	8847	3	and	and	CC
cord-015021-pol2qm74	8847	4	relative	relative	JJ
cord-015021-pol2qm74	8847	5	number	number	NN
cord-015021-pol2qm74	8847	6	of	of	IN
cord-015021-pol2qm74	8847	7	cells	cell	NNS
cord-015021-pol2qm74	8847	8	that	that	WDT
cord-015021-pol2qm74	8847	9	were	be	VBD
cord-015021-pol2qm74	8847	10	positive	positive	JJ
cord-015021-pol2qm74	8847	11	increased	increase	VBN
cord-015021-pol2qm74	8847	12	with	with	IN
cord-015021-pol2qm74	8847	13	lime	lime	NN
cord-015021-pol2qm74	8847	14	.	.	.
cord-015021-pol2qm74	8848	1	Infiltrating	infiltrate	VBG
cord-015021-pol2qm74	8848	2	cells	cell	NNS
cord-015021-pol2qm74	8848	3	and	and	CC
cord-015021-pol2qm74	8848	4	developing	develop	VBG
cord-015021-pol2qm74	8848	5	blood	blood	NN
cord-015021-pol2qm74	8848	6	vessels	vessel	NNS
cord-015021-pol2qm74	8848	7	were	be	VBD
cord-015021-pol2qm74	8848	8	most	most	RBS
cord-015021-pol2qm74	8848	9	prominently	prominently	RB
cord-015021-pol2qm74	8848	10	stained	stain	VBN
cord-015021-pol2qm74	8848	11	;	;	:
cord-015021-pol2qm74	8848	12	epithelial	epithelial	JJ
cord-015021-pol2qm74	8848	13	and	and	CC
cord-015021-pol2qm74	8848	14	T	t	NN
cord-015021-pol2qm74	8848	15	-	-	HYPH
cord-015021-pol2qm74	8848	16	cells	cell	NNS
cord-015021-pol2qm74	8848	17	showed	show	VBD
cord-015021-pol2qm74	8848	18	no	no	DT
cord-015021-pol2qm74	8848	19	immuno	immuno	JJ
cord-015021-pol2qm74	8848	20	-	-	HYPH
cord-015021-pol2qm74	8848	21	reactivity	reactivity	NN
cord-015021-pol2qm74	8848	22	.	.	.
cord-015021-pol2qm74	8849	1	A	a	DT
cord-015021-pol2qm74	8849	2	delay	delay	NN
cord-015021-pol2qm74	8849	3	of	of	IN
cord-015021-pol2qm74	8849	4	emergence	emergence	NN
cord-015021-pol2qm74	8849	5	for	for	IN
cord-015021-pol2qm74	8849	6	TGF	TGF	NNP
cord-015021-pol2qm74	8849	7	-	-	HYPH
cord-015021-pol2qm74	8849	8	B	B	NNP
cord-015021-pol2qm74	8849	9	during	during	IN
cord-015021-pol2qm74	8849	10	the	the	DT
cord-015021-pol2qm74	8849	11	time	time	NN
cord-015021-pol2qm74	8849	12	course	course	NN
cord-015021-pol2qm74	8849	13	could	could	MD
cord-015021-pol2qm74	8849	14	be	be	VB
cord-015021-pol2qm74	8849	15	seen	see	VBN
cord-015021-pol2qm74	8849	16	in	in	IN
cord-015021-pol2qm74	8849	17	one	one	CD
cord-015021-pol2qm74	8849	18	patient	patient	NN
cord-015021-pol2qm74	8849	19	group	group	NN
cord-015021-pol2qm74	8849	20	.	.	.
cord-015021-pol2qm74	8850	1	This	this	DT
cord-015021-pol2qm74	8850	2	might	may	MD
cord-015021-pol2qm74	8850	3	reflect	reflect	VB
cord-015021-pol2qm74	8850	4	various	various	JJ
cord-015021-pol2qm74	8850	5	regulation	regulation	NN
cord-015021-pol2qm74	8850	6	patterns	pattern	NNS
cord-015021-pol2qm74	8850	7	depending	depend	VBG
cord-015021-pol2qm74	8850	8	on	on	IN
cord-015021-pol2qm74	8850	9	the	the	DT
cord-015021-pol2qm74	8850	10	type	type	NN
cord-015021-pol2qm74	8850	11	and	and	CC
cord-015021-pol2qm74	8850	12	severity	severity	NN
cord-015021-pol2qm74	8850	13	of	of	IN
cord-015021-pol2qm74	8850	14	injury.(1	injury.(1	CD
cord-015021-pol2qm74	8850	15	)	)	-RRB-
cord-015021-pol2qm74	8851	1	PharmaTec	PharmaTec	NNP
cord-015021-pol2qm74	8851	2	GmbH	GmbH	NNP
cord-015021-pol2qm74	8851	3	,	,	,
cord-015021-pol2qm74	8851	4	Frankfurt	Frankfurt	NNP
cord-015021-pol2qm74	8851	5	(	(	-LRB-
cord-015021-pol2qm74	8851	6	2	2	CD
cord-015021-pol2qm74	8851	7	)	)	-RRB-
cord-015021-pol2qm74	8851	8	Institut	Institut	NNP
cord-015021-pol2qm74	8851	9	fiir	fiir	VBD
cord-015021-pol2qm74	8851	10	Immonologie	Immonologie	NNP
cord-015021-pol2qm74	8851	11	and	and	CC
cord-015021-pol2qm74	8851	12	Serologic	Serologic	NNP
cord-015021-pol2qm74	8851	13	,	,	,
cord-015021-pol2qm74	8852	1	Heidelberg	Heidelberg	NNP
cord-015021-pol2qm74	8852	2	(	(	-LRB-
cord-015021-pol2qm74	8852	3	Immune	Immune	NNP
cord-015021-pol2qm74	8852	4	cells	cell	NNS
cord-015021-pol2qm74	8852	5	extravasating	extravasate	VBG
cord-015021-pol2qm74	8852	6	specifically	specifically	RB
cord-015021-pol2qm74	8852	7	in	in	IN
cord-015021-pol2qm74	8852	8	skin	skin	NN
cord-015021-pol2qm74	8852	9	recognize	recognize	VBP
cord-015021-pol2qm74	8852	10	and	and	CC
cord-015021-pol2qm74	8852	11	eliminate	eliminate	VB
cord-015021-pol2qm74	8852	12	the	the	DT
cord-015021-pol2qm74	8852	13	invading	invade	VBG
cord-015021-pol2qm74	8852	14	antigens	antigen	NNS
cord-015021-pol2qm74	8852	15	(	(	-LRB-
cord-015021-pol2qm74	8852	16	bacteria	bacteria	NNS
cord-015021-pol2qm74	8852	17	,	,	,
cord-015021-pol2qm74	8852	18	viruses	virus	NNS
cord-015021-pol2qm74	8852	19	,	,	,
cord-015021-pol2qm74	8852	20	etc	etc	FW
cord-015021-pol2qm74	8852	21	.	.	.
cord-015021-pol2qm74	8852	22	)	)	-RRB-
cord-015021-pol2qm74	8853	1	either	either	CC
cord-015021-pol2qm74	8853	2	in	in	IN
cord-015021-pol2qm74	8853	3	situ	situ	NN
cord-015021-pol2qm74	8853	4	or	or	CC
cord-015021-pol2qm74	8853	5	transport	transport	VB
cord-015021-pol2qm74	8853	6	them	-PRON-	PRP
cord-015021-pol2qm74	8853	7	to	to	IN
cord-015021-pol2qm74	8853	8	regional	regional	JJ
cord-015021-pol2qm74	8853	9	lymph	lymph	NN
cord-015021-pol2qm74	8853	10	nodes	node	NNS
cord-015021-pol2qm74	8853	11	.	.	.
cord-015021-pol2qm74	8854	1	They	-PRON-	PRP
cord-015021-pol2qm74	8854	2	also	also	RB
cord-015021-pol2qm74	8854	3	participate	participate	VBP
cord-015021-pol2qm74	8854	4	in	in	IN
cord-015021-pol2qm74	8854	5	the	the	DT
cord-015021-pol2qm74	8854	6	process	process	NN
cord-015021-pol2qm74	8854	7	of	of	IN
cord-015021-pol2qm74	8854	8	skin	skin	NN
cord-015021-pol2qm74	8854	9	wound	wound	NN
cord-015021-pol2qm74	8854	10	healing	healing	NN
cord-015021-pol2qm74	8854	11	.	.	.
cord-015021-pol2qm74	8855	1	Cells	cell	NNS
cord-015021-pol2qm74	8855	2	which	which	WDT
cord-015021-pol2qm74	8855	3	traffic	traffic	NN
cord-015021-pol2qm74	8855	4	through	through	IN
cord-015021-pol2qm74	8855	5	the	the	DT
cord-015021-pol2qm74	8855	6	skin	skin	NN
cord-015021-pol2qm74	8855	7	can	can	MD
cord-015021-pol2qm74	8855	8	be	be	VB
cord-015021-pol2qm74	8855	9	harvested	harvest	VBN
cord-015021-pol2qm74	8855	10	from	from	IN
cord-015021-pol2qm74	8855	11	efferent	efferent	JJ
cord-015021-pol2qm74	8855	12	lymph	lymph	NNS
cord-015021-pol2qm74	8855	13	drained	drain	VBN
cord-015021-pol2qm74	8855	14	from	from	IN
cord-015021-pol2qm74	8855	15	a	a	DT
cord-015021-pol2qm74	8855	16	given	give	VBN
cord-015021-pol2qm74	8855	17	area	area	NN
cord-015021-pol2qm74	8855	18	of	of	IN
cord-015021-pol2qm74	8855	19	skin	skin	NN
cord-015021-pol2qm74	8855	20	.	.	.
cord-015021-pol2qm74	8856	1	The	the	DT
cord-015021-pol2qm74	8856	2	type	type	NN
cord-015021-pol2qm74	8856	3	of	of	IN
cord-015021-pol2qm74	8856	4	migrating	migrate	VBG
cord-015021-pol2qm74	8856	5	cells	cell	NNS
cord-015021-pol2qm74	8856	6	changes	change	NNS
cord-015021-pol2qm74	8856	7	after	after	IN
cord-015021-pol2qm74	8856	8	trauma	trauma	NN
cord-015021-pol2qm74	8856	9	,	,	,
cord-015021-pol2qm74	8856	10	heating	heating	NN
cord-015021-pol2qm74	8856	11	and	and	CC
cord-015021-pol2qm74	8856	12	infection	infection	NN
cord-015021-pol2qm74	8856	13	.	.	.
cord-015021-pol2qm74	8857	1	We	-PRON-	PRP
cord-015021-pol2qm74	8857	2	have	have	VBP
cord-015021-pol2qm74	8857	3	developed	develop	VBN
cord-015021-pol2qm74	8857	4	a	a	DT
cord-015021-pol2qm74	8857	5	method	method	NN
cord-015021-pol2qm74	8857	6	for	for	IN
cord-015021-pol2qm74	8857	7	collection	collection	NN
cord-015021-pol2qm74	8857	8	of	of	IN
cord-015021-pol2qm74	8857	9	human	human	JJ
cord-015021-pol2qm74	8857	10	afferent	afferent	JJ
cord-015021-pol2qm74	8857	11	lymph	lymph	NN
cord-015021-pol2qm74	8857	12	in	in	IN
cord-015021-pol2qm74	8857	13	lower	low	JJR
cord-015021-pol2qm74	8857	14	limbs	limb	NNS
cord-015021-pol2qm74	8857	15	.	.	.
cord-015021-pol2qm74	8858	1	The	the	DT
cord-015021-pol2qm74	8858	2	method	method	NN
cord-015021-pol2qm74	8858	3	allows	allow	VBZ
cord-015021-pol2qm74	8858	4	obtaining	obtain	VBG
cord-015021-pol2qm74	8858	5	immune	immune	JJ
cord-015021-pol2qm74	8858	6	cells	cell	NNS
cord-015021-pol2qm74	8858	7	from	from	IN
cord-015021-pol2qm74	8858	8	normal	normal	JJ
cord-015021-pol2qm74	8858	9	and	and	CC
cord-015021-pol2qm74	8858	10	injured	injured	JJ
cord-015021-pol2qm74	8858	11	skin	skin	NN
cord-015021-pol2qm74	8858	12	and	and	CC
cord-015021-pol2qm74	8858	13	their	-PRON-	PRP$
cord-015021-pol2qm74	8858	14	characterization	characterization	NN
cord-015021-pol2qm74	8858	15	.	.	.
cord-015021-pol2qm74	8859	1	AIM	aim	VB
cord-015021-pol2qm74	8859	2	OF	of	IN
cord-015021-pol2qm74	8859	3	THE	the	DT
cord-015021-pol2qm74	8859	4	STUDY	study	NN
cord-015021-pol2qm74	8859	5	was	be	VBD
cord-015021-pol2qm74	8859	6	to	to	TO
cord-015021-pol2qm74	8859	7	characterize	characterize	VB
cord-015021-pol2qm74	8859	8	skin	skin	NN
cord-015021-pol2qm74	8859	9	immune	immune	JJ
cord-015021-pol2qm74	8859	10	cells	cell	NNS
cord-015021-pol2qm74	8859	11	in	in	IN
cord-015021-pol2qm74	8859	12	situ	situ	NN
cord-015021-pol2qm74	8859	13	and	and	CC
cord-015021-pol2qm74	8859	14	in	in	IN
cord-015021-pol2qm74	8859	15	skin	skin	NN
cord-015021-pol2qm74	8859	16	lymph	lymph	NN
cord-015021-pol2qm74	8859	17	with	with	IN
cord-015021-pol2qm74	8859	18	use	use	NN
cord-015021-pol2qm74	8859	19	of	of	IN
cord-015021-pol2qm74	8859	20	immunohistological	immunohistological	JJ
cord-015021-pol2qm74	8859	21	methods	method	NNS
cord-015021-pol2qm74	8859	22	(	(	-LRB-
cord-015021-pol2qm74	8859	23	staining	stain	VBG
cord-015021-pol2qm74	8859	24	,	,	,
cord-015021-pol2qm74	8859	25	FACS	FACS	NNP
cord-015021-pol2qm74	8859	26	)	)	-RRB-
cord-015021-pol2qm74	8859	27	.	.	.
cord-015021-pol2qm74	8860	1	RESULTS	result	NNS
cord-015021-pol2qm74	8860	2	.	.	.
cord-015021-pol2qm74	8861	1	Group	group	NN
cord-015021-pol2qm74	8861	2	1	1	CD
cord-015021-pol2qm74	8861	3	,	,	,
cord-015021-pol2qm74	8861	4	cells	cell	NNS
cord-015021-pol2qm74	8861	5	migrating	migrate	VBG
cord-015021-pol2qm74	8861	6	through	through	IN
cord-015021-pol2qm74	8861	7	skin	skin	NN
cord-015021-pol2qm74	8861	8	:	:	:
cord-015021-pol2qm74	8861	9	75	75	CD
cord-015021-pol2qm74	8861	10	+	+	SYM
cord-015021-pol2qm74	8861	11	4	4	CD
cord-015021-pol2qm74	8861	12	%	%	NN
cord-015021-pol2qm74	8861	13	T	t	NN
cord-015021-pol2qm74	8861	14	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8861	15	(	(	-LRB-
cord-015021-pol2qm74	8861	16	CD3	CD3	NNP
cord-015021-pol2qm74	8861	17	)	)	-RRB-
cord-015021-pol2qm74	8861	18	,	,	,
cord-015021-pol2qm74	8861	19	6	6	CD
cord-015021-pol2qm74	8861	20	+	+	SYM
cord-015021-pol2qm74	8861	21	3	3	CD
cord-015021-pol2qm74	8861	22	%	%	NN
cord-015021-pol2qm74	8861	23	Langerhans	langerhan	NNS
cord-015021-pol2qm74	8861	24	and	and	CC
cord-015021-pol2qm74	8861	25	dendritic	dendritic	JJ
cord-015021-pol2qm74	8861	26	cells	cell	NNS
cord-015021-pol2qm74	8861	27	(	(	-LRB-
cord-015021-pol2qm74	8861	28	CDla	CDla	NNP
cord-015021-pol2qm74	8861	29	,	,	,
cord-015021-pol2qm74	8861	30	HLA	HLA	NNP
cord-015021-pol2qm74	8861	31	DR	DR	NNP
cord-015021-pol2qm74	8861	32	,	,	,
cord-015021-pol2qm74	8861	33	S100	S100	NNP
cord-015021-pol2qm74	8861	34	)	)	-RRB-
cord-015021-pol2qm74	8861	35	,	,	.
cord-015021-pol2qm74	8862	1	41	41	CD
cord-015021-pol2qm74	8862	2	+	+	SYM
cord-015021-pol2qm74	8862	3	9	9	CD
cord-015021-pol2qm74	8862	4	%	%	NN
cord-015021-pol2qm74	8862	5	CD4	CD4	NNP
cord-015021-pol2qm74	8862	6	,	,	,
cord-015021-pol2qm74	8862	7	18	18	CD
cord-015021-pol2qm74	8862	8	+	+	SYM
cord-015021-pol2qm74	8862	9	6	6	CD
cord-015021-pol2qm74	8862	10	%	%	NN
cord-015021-pol2qm74	8862	11	CD8	CD8	NNP
cord-015021-pol2qm74	8862	12	,	,	,
cord-015021-pol2qm74	8862	13	no	no	DT
cord-015021-pol2qm74	8862	14	B	b	NN
cord-015021-pol2qm74	8862	15	cells	cell	NNS
cord-015021-pol2qm74	8862	16	(	(	-LRB-
cord-015021-pol2qm74	8862	17	CD22	CD22	NNP
cord-015021-pol2qm74	8862	18	,	,	,
cord-015021-pol2qm74	8862	19	23	23	CD
cord-015021-pol2qm74	8862	20	)	)	-RRB-
cord-015021-pol2qm74	8862	21	,	,	,
cord-015021-pol2qm74	8862	22	74	74	CD
cord-015021-pol2qm74	8862	23	%	%	NN
cord-015021-pol2qm74	8862	24	CD45R0	cd45r0	NN
cord-015021-pol2qm74	8862	25	(	(	-LRB-
cord-015021-pol2qm74	8862	26	memory	memory	NN
cord-015021-pol2qm74	8862	27	cells	cell	NNS
cord-015021-pol2qm74	8862	28	)	)	-RRB-
cord-015021-pol2qm74	8862	29	,	,	,
cord-015021-pol2qm74	8862	30	6	6	CD
cord-015021-pol2qm74	8862	31	+	+	SYM
cord-015021-pol2qm74	8862	32	3	3	CD
cord-015021-pol2qm74	8862	33	%	%	NN
cord-015021-pol2qm74	8863	1	IL2R.	IL2R.	NNP
cord-015021-pol2qm74	8863	2	Approximately	approximately	RB
cord-015021-pol2qm74	8863	3	90	90	CD
cord-015021-pol2qm74	8863	4	%	%	NN
cord-015021-pol2qm74	8863	5	cells	cell	NNS
cord-015021-pol2qm74	8863	6	possessed	possess	VBD
cord-015021-pol2qm74	8863	7	CDlla	CDlla	NNPS
cord-015021-pol2qm74	8863	8	and	and	CC
cord-015021-pol2qm74	8863	9	18	18	CD
cord-015021-pol2qm74	8863	10	antigens	antigen	NNS
cord-015021-pol2qm74	8863	11	.	.	.
cord-015021-pol2qm74	8864	1	CD1	CD1	NNP
cord-015021-pol2qm74	8864	2	lc	lc	NNP
cord-015021-pol2qm74	8864	3	was	be	VBD
cord-015021-pol2qm74	8864	4	expressed	express	VBN
cord-015021-pol2qm74	8864	5	only	only	RB
cord-015021-pol2qm74	8864	6	on	on	IN
cord-015021-pol2qm74	8864	7	large	large	JJ
cord-015021-pol2qm74	8864	8	cells	cell	NNS
cord-015021-pol2qm74	8864	9	.	.	.
cord-015021-pol2qm74	8865	1	The	the	DT
cord-015021-pol2qm74	8865	2	frequency	frequency	NN
cord-015021-pol2qm74	8865	3	of	of	IN
cord-015021-pol2qm74	8865	4	all	all	DT
cord-015021-pol2qm74	8865	5	phenotypes	phenotype	NNS
cord-015021-pol2qm74	8865	6	was	be	VBD
cord-015021-pol2qm74	8865	7	different	different	JJ
cord-015021-pol2qm74	8865	8	from	from	IN
cord-015021-pol2qm74	8865	9	the	the	DT
cord-015021-pol2qm74	8865	10	blood	blood	NN
cord-015021-pol2qm74	8865	11	populations	population	NNS
cord-015021-pol2qm74	8865	12	.	.	.
cord-015021-pol2qm74	8866	1	Group	group	NN
cord-015021-pol2qm74	8866	2	2	2	CD
cord-015021-pol2qm74	8866	3	,	,	,
cord-015021-pol2qm74	8866	4	cells	cell	NNS
cord-015021-pol2qm74	8866	5	in	in	IN
cord-015021-pol2qm74	8866	6	skin	skin	NN
cord-015021-pol2qm74	8866	7	:	:	:
cord-015021-pol2qm74	8867	1	Langerhans	Langerhans	NNP
cord-015021-pol2qm74	8867	2	cells	cell	NNS
cord-015021-pol2qm74	8867	3	were	be	VBD
cord-015021-pol2qm74	8867	4	found	find	VBN
cord-015021-pol2qm74	8867	5	only	only	RB
cord-015021-pol2qm74	8867	6	in	in	IN
cord-015021-pol2qm74	8867	7	epidermis	epidermis	NN
cord-015021-pol2qm74	8867	8	,	,	,
cord-015021-pol2qm74	8867	9	CD3,4	CD3,4	NNP
cord-015021-pol2qm74	8867	10	and	and	CC
cord-015021-pol2qm74	8867	11	8	8	CD
cord-015021-pol2qm74	8867	12	,	,	,
cord-015021-pol2qm74	8867	13	CD45R0	cd45r0	NN
cord-015021-pol2qm74	8867	14	,	,	,
cord-015021-pol2qm74	8867	15	RB	RB	NNP
cord-015021-pol2qm74	8867	16	,	,	,
cord-015021-pol2qm74	8867	17	ila/18	ila/18	NNP
cord-015021-pol2qm74	8867	18	cells	cell	NNS
cord-015021-pol2qm74	8867	19	around	around	IN
cord-015021-pol2qm74	8867	20	venules	venule	NNS
cord-015021-pol2qm74	8867	21	,	,	,
cord-015021-pol2qm74	8867	22	CD68	CD68	NNP
cord-015021-pol2qm74	8867	23	(	(	-LRB-
cord-015021-pol2qm74	8867	24	macrophages	macrophage	NNS
cord-015021-pol2qm74	8867	25	)	)	-RRB-
cord-015021-pol2qm74	8867	26	uniformly	uniformly	RB
cord-015021-pol2qm74	8867	27	dispersed	disperse	VBN
cord-015021-pol2qm74	8867	28	,	,	,
cord-015021-pol2qm74	8867	29	no	no	UH
cord-015021-pol2qm74	8867	30	IL2R	il2r	NN
cord-015021-pol2qm74	8867	31	and	and	CC
cord-015021-pol2qm74	8867	32	B	b	NN
cord-015021-pol2qm74	8867	33	cells	cell	NNS
cord-015021-pol2qm74	8867	34	.	.	.
cord-015021-pol2qm74	8868	1	HLA	HLA	NNP
cord-015021-pol2qm74	8868	2	DR	DR	NNP
cord-015021-pol2qm74	8868	3	positive	positive	JJ
cord-015021-pol2qm74	8868	4	were	be	VBD
cord-015021-pol2qm74	8868	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	8868	6	and	and	CC
cord-015021-pol2qm74	8868	7	some	some	DT
cord-015021-pol2qm74	8868	8	dispersed	disperse	VBN
cord-015021-pol2qm74	8868	9	mononuclear	mononuclear	JJ
cord-015021-pol2qm74	8868	10	cells	cell	NNS
cord-015021-pol2qm74	8868	11	.	.	.
cord-015021-pol2qm74	8869	1	Group	group	NN
cord-015021-pol2qm74	8869	2	3	3	CD
cord-015021-pol2qm74	8869	3	,	,	,
cord-015021-pol2qm74	8869	4	one	one	CD
cord-015021-pol2qm74	8869	5	,	,	,
cord-015021-pol2qm74	8869	6	three	three	CD
cord-015021-pol2qm74	8869	7	and	and	CC
cord-015021-pol2qm74	8869	8	thirty	thirty	CD
cord-015021-pol2qm74	8869	9	days	day	NNS
cord-015021-pol2qm74	8869	10	after	after	IN
cord-015021-pol2qm74	8869	11	surgical	surgical	JJ
cord-015021-pol2qm74	8869	12	wound	wound	NN
cord-015021-pol2qm74	8869	13	(	(	-LRB-
cord-015021-pol2qm74	8869	14	simple	simple	JJ
cord-015021-pol2qm74	8869	15	varicous	varicous	JJ
cord-015021-pol2qm74	8869	16	vein	vein	NN
cord-015021-pol2qm74	8869	17	extirpation	extirpation	NN
cord-015021-pol2qm74	8869	18	)	)	-RRB-
cord-015021-pol2qm74	8869	19	:	:	:
cord-015021-pol2qm74	8869	20	high	high	JJ
cord-015021-pol2qm74	8869	21	density	density	NN
cord-015021-pol2qm74	8869	22	of	of	IN
cord-015021-pol2qm74	8869	23	epidermal	epidermal	JJ
cord-015021-pol2qm74	8869	24	Langerhans	Langerhans	NNP
cord-015021-pol2qm74	8869	25	cells	cell	NNS
cord-015021-pol2qm74	8869	26	,	,	,
cord-015021-pol2qm74	8869	27	HLA	HLA	NNP
cord-015021-pol2qm74	8869	28	DR	DR	NNP
cord-015021-pol2qm74	8869	29	positive	positive	JJ
cord-015021-pol2qm74	8869	30	keratinocytes	keratinocyte	NNS
cord-015021-pol2qm74	8869	31	and	and	CC
cord-015021-pol2qm74	8869	32	all	all	DT
cord-015021-pol2qm74	8869	33	endothelial	endothelial	JJ
cord-015021-pol2qm74	8869	34	ceils	ceil	NNS
cord-015021-pol2qm74	8869	35	,	,	,
cord-015021-pol2qm74	8869	36	few	few	JJ
cord-015021-pol2qm74	8869	37	IL2R	IL2R	NNS
cord-015021-pol2qm74	8869	38	cells	cell	NNS
cord-015021-pol2qm74	8869	39	,	,	,
cord-015021-pol2qm74	8869	40	perivenular	perivenular	NNP
cord-015021-pol2qm74	8869	41	infiltrates	infiltrate	VBZ
cord-015021-pol2qm74	8869	42	of	of	IN
cord-015021-pol2qm74	8869	43	CD68	CD68	NNP
cord-015021-pol2qm74	8869	44	,	,	,
cord-015021-pol2qm74	8869	45	45R0	45r0	CD
cord-015021-pol2qm74	8869	46	but	but	CC
cord-015021-pol2qm74	8869	47	less	less	JJR
cord-015021-pol2qm74	8869	48	CD3	cd3	NN
cord-015021-pol2qm74	8869	49	cells	cell	NNS
cord-015021-pol2qm74	8869	50	,	,	,
cord-015021-pol2qm74	8869	51	high	high	JJ
cord-015021-pol2qm74	8869	52	density	density	NN
cord-015021-pol2qm74	8869	53	of	of	IN
cord-015021-pol2qm74	8869	54	CDlla/18	CDlla/18	NNP
cord-015021-pol2qm74	8869	55	cells	cell	NNS
cord-015021-pol2qm74	8869	56	.	.	.
cord-015021-pol2qm74	8870	1	Classic	classic	JJ
cord-015021-pol2qm74	8870	2	staining	staining	NN
cord-015021-pol2qm74	8870	3	of	of	IN
cord-015021-pol2qm74	8870	4	isolated	isolated	JJ
cord-015021-pol2qm74	8870	5	and	and	CC
cord-015021-pol2qm74	8870	6	in	in	IN
cord-015021-pol2qm74	8870	7	situ	situ	FW
cord-015021-pol2qm74	8870	8	located	locate	VBN
cord-015021-pol2qm74	8870	9	ccl!s	ccl!s	NNP
cord-015021-pol2qm74	8870	10	with	with	IN
cord-015021-pol2qm74	8870	11	MGG	MGG	NNP
cord-015021-pol2qm74	8870	12	or	or	CC
cord-015021-pol2qm74	8870	13	HE	HE	NNP
cord-015021-pol2qm74	8870	14	did	do	VBD
cord-015021-pol2qm74	8870	15	not	not	RB
cord-015021-pol2qm74	8870	16	allow	allow	VB
cord-015021-pol2qm74	8870	17	to	to	TO
cord-015021-pol2qm74	8870	18	follow	follow	VB
cord-015021-pol2qm74	8870	19	kinetics	kinetic	NNS
cord-015021-pol2qm74	8870	20	of	of	IN
cord-015021-pol2qm74	8870	21	changes	change	NNS
cord-015021-pol2qm74	8870	22	.	.	.
cord-015021-pol2qm74	8871	1	CONCLUSIONS	conclusion	NNS
cord-015021-pol2qm74	8871	2	.	.	.
cord-015021-pol2qm74	8872	1	This	this	DT
cord-015021-pol2qm74	8872	2	study	study	NN
cord-015021-pol2qm74	8872	3	presents	present	VBZ
cord-015021-pol2qm74	8872	4	the	the	DT
cord-015021-pol2qm74	8872	5	first	first	JJ
cord-015021-pol2qm74	8872	6	in	in	IN
cord-015021-pol2qm74	8872	7	the	the	DT
cord-015021-pol2qm74	8872	8	literature	literature	NN
cord-015021-pol2qm74	8872	9	quantitative	quantitative	JJ
cord-015021-pol2qm74	8872	10	data	datum	NNS
cord-015021-pol2qm74	8872	11	of	of	IN
cord-015021-pol2qm74	8872	12	immune	immune	JJ
cord-015021-pol2qm74	8872	13	cell	cell	NN
cord-015021-pol2qm74	8872	14	traffic	traffic	NN
cord-015021-pol2qm74	8872	15	through	through	IN
cord-015021-pol2qm74	8872	16	normal	normal	JJ
cord-015021-pol2qm74	8872	17	and	and	CC
cord-015021-pol2qm74	8872	18	injured	injured	JJ
cord-015021-pol2qm74	8872	19	human	human	JJ
cord-015021-pol2qm74	8872	20	skin	skin	NN
cord-015021-pol2qm74	8872	21	.	.	.
cord-015021-pol2qm74	8873	1	IN	in	IN
cord-015021-pol2qm74	8873	2	THE	the	DT
cord-015021-pol2qm74	8873	3	 	 	_SP
cord-015021-pol2qm74	8873	4	CONTROLLED	CONTROLLED	NNP
cord-015021-pol2qm74	8873	5	 	 	_SP
cord-015021-pol2qm74	8873	6	RELEASE	RELEASE	VBN
cord-015021-pol2qm74	8873	7	 	 	_SP
cord-015021-pol2qm74	8873	8	OF	of	IN
cord-015021-pol2qm74	8873	9	 	 	_SP
cord-015021-pol2qm74	8873	10	BIOLOGICAL	BIOLOGICAL	NNP
cord-015021-pol2qm74	8873	11	 	 	_SP
cord-015021-pol2qm74	8873	12	RESPONSE	response	NN
cord-015021-pol2qm74	8873	13	 	 	_SP
cord-015021-pol2qm74	8873	14	MODIFIERS	modifier	NNS
cord-015021-pol2qm74	8873	15	FOR	for	IN
cord-015021-pol2qm74	8873	16	SOFT	soft	JJ
cord-015021-pol2qm74	8873	17	TISSUE	tissue	NN
cord-015021-pol2qm74	8873	18	REGENERATION	regeneration	NN
cord-015021-pol2qm74	8873	19	.	.	.
cord-015021-pol2qm74	8874	1	Alan	Alan	NNP
cord-015021-pol2qm74	8874	2	S.	S.	NNP
cord-015021-pol2qm74	8874	3	Rudolph	Rudolph	NNP
cord-015021-pol2qm74	8874	4	,	,	,
cord-015021-pol2qm74	8874	5	Helmut	Helmut	NNP
cord-015021-pol2qm74	8874	6	Speilberg	Speilberg	NNP
cord-015021-pol2qm74	8874	7	,	,	,
cord-015021-pol2qm74	8874	8	Mariam	Mariam	NNP
cord-015021-pol2qm74	8874	9	Monshipouri	Monshipouri	NNP
cord-015021-pol2qm74	8874	10	,	,	,
cord-015021-pol2qm74	8874	11	and	and	CC
cord-015021-pol2qm74	8874	12	Florence	Florence	NNP
cord-015021-pol2qm74	8874	13	Rollwagen	Rollwagen	NNP
cord-015021-pol2qm74	8874	14	,	,	,
cord-015021-pol2qm74	8874	15	and	and	CC
cord-015021-pol2qm74	8874	16	Barry	Barry	NNP
cord-015021-pol2qm74	8874	17	J.	J.	NNP
cord-015021-pol2qm74	8874	18	Spargo	Spargo	NNP
cord-015021-pol2qm74	8874	19	.	.	.
cord-015021-pol2qm74	8875	1	We	-PRON-	PRP
cord-015021-pol2qm74	8875	2	have	have	VBP
cord-015021-pol2qm74	8875	3	employed	employ	VBN
cord-015021-pol2qm74	8875	4	lipid	lipid	NN
cord-015021-pol2qm74	8875	5	microstructures	microstructure	NNS
cord-015021-pol2qm74	8875	6	as	as	IN
cord-015021-pol2qm74	8875	7	controlled	control	VBN
cord-015021-pol2qm74	8875	8	release	release	NN
cord-015021-pol2qm74	8875	9	vehicles	vehicle	NNS
cord-015021-pol2qm74	8875	10	for	for	IN
cord-015021-pol2qm74	8875	11	the	the	DT
cord-015021-pol2qm74	8875	12	delivery	delivery	NN
cord-015021-pol2qm74	8875	13	of	of	IN
cord-015021-pol2qm74	8875	14	growth	growth	NN
cord-015021-pol2qm74	8875	15	factors	factor	NNS
cord-015021-pol2qm74	8875	16	in	in	IN
cord-015021-pol2qm74	8875	17	wound	wound	NN
cord-015021-pol2qm74	8875	18	repair	repair	NN
cord-015021-pol2qm74	8875	19	.	.	.
cord-015021-pol2qm74	8876	1	Traditional	traditional	JJ
cord-015021-pol2qm74	8876	2	liposomes	liposome	NNS
cord-015021-pol2qm74	8876	3	as	as	RB
cord-015021-pol2qm74	8876	4	well	well	RB
cord-015021-pol2qm74	8876	5	as	as	IN
cord-015021-pol2qm74	8876	6	novel	novel	JJ
cord-015021-pol2qm74	8876	7	lipid	lipid	NN
cord-015021-pol2qm74	8876	8	based	base	VBN
cord-015021-pol2qm74	8876	9	microcylinders	microcylinder	NNS
cord-015021-pol2qm74	8876	10	have	have	VBP
cord-015021-pol2qm74	8876	11	been	be	VBN
cord-015021-pol2qm74	8876	12	examined	examine	VBN
cord-015021-pol2qm74	8876	13	for	for	IN
cord-015021-pol2qm74	8876	14	their	-PRON-	PRP$
cord-015021-pol2qm74	8876	15	in	in	FW
cord-015021-pol2qm74	8876	16	vitro	vitro	FW
cord-015021-pol2qm74	8876	17	kinetics	kinetic	NNS
cord-015021-pol2qm74	8876	18	of	of	IN
cord-015021-pol2qm74	8876	19	the	the	DT
cord-015021-pol2qm74	8876	20	release	release	NN
cord-015021-pol2qm74	8876	21	of	of	IN
cord-015021-pol2qm74	8876	22	transforming	transform	VBG
cord-015021-pol2qm74	8876	23	growth	growth	NN
cord-015021-pol2qm74	8876	24	factor	factor	NN
cord-015021-pol2qm74	8876	25	beta	beta	NN
cord-015021-pol2qm74	8876	26	(	(	-LRB-
cord-015021-pol2qm74	8876	27	TGF	TGF	NNP
cord-015021-pol2qm74	8876	28	-	-	HYPH
cord-015021-pol2qm74	8876	29	b	b	NN
cord-015021-pol2qm74	8876	30	)	)	-RRB-
cord-015021-pol2qm74	8876	31	.	.	.
cord-015021-pol2qm74	8877	1	In	in	IN
cord-015021-pol2qm74	8877	2	vitro	vitro	FW
cord-015021-pol2qm74	8877	3	reiease	reiease	NN
cord-015021-pol2qm74	8877	4	has	have	VBZ
cord-015021-pol2qm74	8877	5	been	be	VBN
cord-015021-pol2qm74	8877	6	examined	examine	VBN
cord-015021-pol2qm74	8877	7	by	by	IN
cord-015021-pol2qm74	8877	8	setting	set	VBG
cord-015021-pol2qm74	8877	9	up	up	RP
cord-015021-pol2qm74	8877	10	models	model	NNS
cord-015021-pol2qm74	8877	11	with	with	IN
cord-015021-pol2qm74	8877	12	examine	examine	VB
cord-015021-pol2qm74	8877	13	the	the	DT
cord-015021-pol2qm74	8877	14	physical	physical	JJ
cord-015021-pol2qm74	8877	15	release	release	NN
cord-015021-pol2qm74	8877	16	of	of	IN
cord-015021-pol2qm74	8877	17	iodinated	iodinate	VBN
cord-015021-pol2qm74	8877	18	TGF	TGF	NNP
cord-015021-pol2qm74	8877	19	-	-	HYPH
cord-015021-pol2qm74	8877	20	b	b	NNP
cord-015021-pol2qm74	8877	21	as	as	RB
cord-015021-pol2qm74	8877	22	well	well	RB
cord-015021-pol2qm74	8877	23	as	as	IN
cord-015021-pol2qm74	8877	24	a	a	DT
cord-015021-pol2qm74	8877	25	cell	cell	NN
cord-015021-pol2qm74	8877	26	based	base	VBN
cord-015021-pol2qm74	8877	27	bioassay	bioassay	NN
cord-015021-pol2qm74	8877	28	(	(	-LRB-
cord-015021-pol2qm74	8877	29	based	base	VBN
cord-015021-pol2qm74	8877	30	on	on	IN
cord-015021-pol2qm74	8877	31	the	the	DT
cord-015021-pol2qm74	8877	32	HT3	ht3	JJ
cord-015021-pol2qm74	8877	33	bioassay	bioassay	NN
cord-015021-pol2qm74	8877	34	)	)	-RRB-
cord-015021-pol2qm74	8877	35	.	.	.
cord-015021-pol2qm74	8878	1	The	the	DT
cord-015021-pol2qm74	8878	2	hollow	hollow	JJ
cord-015021-pol2qm74	8878	3	lipid	lipid	NN
cord-015021-pol2qm74	8878	4	microcylinders	microcylinder	NNS
cord-015021-pol2qm74	8878	5	(	(	-LRB-
cord-015021-pol2qm74	8878	6	50	50	CD
cord-015021-pol2qm74	8878	7	microns	micron	NNS
cord-015021-pol2qm74	8878	8	in	in	IN
cord-015021-pol2qm74	8878	9	length	length	NN
cord-015021-pol2qm74	8879	1	and	and	CC
cord-015021-pol2qm74	8879	2	I	-PRON-	PRP
cord-015021-pol2qm74	8879	3	micron	micron	VBP
cord-015021-pol2qm74	8879	4	in	in	IN
cord-015021-pol2qm74	8879	5	diameter	diameter	NN
cord-015021-pol2qm74	8879	6	)	)	-RRB-
cord-015021-pol2qm74	8880	1	show	show	VB
cord-015021-pol2qm74	8880	2	an	an	DT
cord-015021-pol2qm74	8880	3	initial	initial	JJ
cord-015021-pol2qm74	8880	4	burst	burst	NN
cord-015021-pol2qm74	8880	5	(	(	-LRB-
cord-015021-pol2qm74	8880	6	5	5	CD
cord-015021-pol2qm74	8880	7	-	-	SYM
cord-015021-pol2qm74	8880	8	10	10	CD
cord-015021-pol2qm74	8880	9	ng	ng	NN
cord-015021-pol2qm74	8880	10	)	)	-RRB-
cord-015021-pol2qm74	8880	11	followed	follow	VBD
cord-015021-pol2qm74	8880	12	be	be	VB
cord-015021-pol2qm74	8880	13	zero	zero	CD
cord-015021-pol2qm74	8880	14	order	order	NN
cord-015021-pol2qm74	8880	15	kinetics	kinetics	NN
cord-015021-pol2qm74	8880	16	which	which	WDT
cord-015021-pol2qm74	8880	17	result	result	VBP
cord-015021-pol2qm74	8880	18	in	in	IN
cord-015021-pol2qm74	8880	19	the	the	DT
cord-015021-pol2qm74	8880	20	release	release	NN
cord-015021-pol2qm74	8880	21	of	of	IN
cord-015021-pol2qm74	8880	22	approximately	approximately	RB
cord-015021-pol2qm74	8880	23	I	-PRON-	PRP
cord-015021-pol2qm74	8880	24	ng	ng	NNP
cord-015021-pol2qm74	8880	25	TGF	TGF	NNP
cord-015021-pol2qm74	8880	26	/	/	SYM
cord-015021-pol2qm74	8880	27	day	day	NN
cord-015021-pol2qm74	8880	28	.	.	.
cord-015021-pol2qm74	8881	1	This	this	DT
cord-015021-pol2qm74	8881	2	release	release	NN
cord-015021-pol2qm74	8881	3	behavior	behavior	NN
cord-015021-pol2qm74	8881	4	can	can	MD
cord-015021-pol2qm74	8881	5	be	be	VB
cord-015021-pol2qm74	8881	6	modified	modify	VBN
cord-015021-pol2qm74	8881	7	by	by	IN
cord-015021-pol2qm74	8881	8	temperature	temperature	NN
cord-015021-pol2qm74	8881	9	based	base	VBN
cord-015021-pol2qm74	8881	10	on	on	IN
cord-015021-pol2qm74	8881	11	the	the	DT
cord-015021-pol2qm74	8881	12	phase	phase	NN
cord-015021-pol2qm74	8881	13	behavior	behavior	NN
cord-015021-pol2qm74	8881	14	of	of	IN
cord-015021-pol2qm74	8881	15	the	the	DT
cord-015021-pol2qm74	8881	16	lipid	lipid	NN
cord-015021-pol2qm74	8881	17	bilayer	bilayer	NN
cord-015021-pol2qm74	8881	18	which	which	WDT
cord-015021-pol2qm74	8881	19	comprises	comprise	VBZ
cord-015021-pol2qm74	8881	20	the	the	DT
cord-015021-pol2qm74	8881	21	microcylinder	microcylinder	NN
cord-015021-pol2qm74	8881	22	.	.	.
cord-015021-pol2qm74	8882	1	We	-PRON-	PRP
cord-015021-pol2qm74	8882	2	have	have	VBP
cord-015021-pol2qm74	8882	3	also	also	RB
cord-015021-pol2qm74	8882	4	examined	examine	VBN
cord-015021-pol2qm74	8882	5	the	the	DT
cord-015021-pol2qm74	8882	6	cellular	cellular	JJ
cord-015021-pol2qm74	8882	7	response	response	NN
cord-015021-pol2qm74	8882	8	to	to	IN
cord-015021-pol2qm74	8882	9	lipid	lipid	NN
cord-015021-pol2qm74	8882	10	microcylinders	microcylinder	NNS
cord-015021-pol2qm74	8882	11	applied	apply	VBN
cord-015021-pol2qm74	8882	12	in	in	IN
cord-015021-pol2qm74	8882	13	vivo	vivo	NNP
cord-015021-pol2qm74	8882	14	.	.	.
cord-015021-pol2qm74	8883	1	The	the	DT
cord-015021-pol2qm74	8883	2	lipid	lipid	NN
cord-015021-pol2qm74	8883	3	microcylinders	microcylinder	NNS
cord-015021-pol2qm74	8883	4	are	be	VBP
cord-015021-pol2qm74	8883	5	mixed	mix	VBN
cord-015021-pol2qm74	8883	6	in	in	IN
cord-015021-pol2qm74	8883	7	agarose	agarose	JJ
cord-015021-pol2qm74	8883	8	and	and	CC
cord-015021-pol2qm74	8883	9	implanted	implant	VBN
cord-015021-pol2qm74	8883	10	as	as	IN
cord-015021-pol2qm74	8883	11	a	a	DT
cord-015021-pol2qm74	8883	12	composite	composite	JJ
cord-015021-pol2qm74	8883	13	hydrogel	hydrogel	NN
cord-015021-pol2qm74	8883	14	block	block	NN
cord-015021-pol2qm74	8883	15	under	under	IN
cord-015021-pol2qm74	8883	16	the	the	DT
cord-015021-pol2qm74	8883	17	flank	flank	NN
cord-015021-pol2qm74	8883	18	of	of	IN
cord-015021-pol2qm74	8883	19	a	a	DT
cord-015021-pol2qm74	8883	20	mouse	mouse	NN
cord-015021-pol2qm74	8883	21	.	.	.
cord-015021-pol2qm74	8884	1	The	the	DT
cord-015021-pol2qm74	8884	2	blocks	block	NNS
cord-015021-pol2qm74	8884	3	are	be	VBP
cord-015021-pol2qm74	8884	4	removed	remove	VBN
cord-015021-pol2qm74	8884	5	1	1	CD
cord-015021-pol2qm74	8884	6	,	,	,
cord-015021-pol2qm74	8884	7	3	3	CD
cord-015021-pol2qm74	8884	8	,	,	,
cord-015021-pol2qm74	8884	9	and	and	CC
cord-015021-pol2qm74	8884	10	5	5	CD
cord-015021-pol2qm74	8884	11	days	day	NNS
cord-015021-pol2qm74	8884	12	following	follow	VBG
cord-015021-pol2qm74	8884	13	implant	implant	JJ
cord-015021-pol2qm74	8884	14	and	and	CC
cord-015021-pol2qm74	8884	15	the	the	DT
cord-015021-pol2qm74	8884	16	cells	cell	NNS
cord-015021-pol2qm74	8884	17	analyzed	analyze	VBN
cord-015021-pol2qm74	8884	18	by	by	IN
cord-015021-pol2qm74	8884	19	FACs	FACs	NNP
cord-015021-pol2qm74	8884	20	sorter	sorter	NN
cord-015021-pol2qm74	8884	21	analysis	analysis	NN
cord-015021-pol2qm74	8884	22	.	.	.
cord-015021-pol2qm74	8885	1	The	the	DT
cord-015021-pol2qm74	8885	2	observed	observed	JJ
cord-015021-pol2qm74	8885	3	pattern	pattern	NN
cord-015021-pol2qm74	8885	4	of	of	IN
cord-015021-pol2qm74	8885	5	ceil	ceil	NN
cord-015021-pol2qm74	8885	6	recruitment	recruitment	NN
cord-015021-pol2qm74	8885	7	to	to	IN
cord-015021-pol2qm74	8885	8	the	the	DT
cord-015021-pol2qm74	8885	9	blocks	block	NNS
cord-015021-pol2qm74	8885	10	mimics	mimic	VBZ
cord-015021-pol2qm74	8885	11	that	that	WDT
cord-015021-pol2qm74	8885	12	seen	see	VBN
cord-015021-pol2qm74	8885	13	in	in	IN
cord-015021-pol2qm74	8885	14	a	a	DT
cord-015021-pol2qm74	8885	15	local	local	JJ
cord-015021-pol2qm74	8885	16	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8885	17	response	response	NN
cord-015021-pol2qm74	8885	18	.	.	.
cord-015021-pol2qm74	8886	1	Cell	cell	NN
cord-015021-pol2qm74	8886	2	surface	surface	NN
cord-015021-pol2qm74	8886	3	phenotype	phenotype	NN
cord-015021-pol2qm74	8886	4	studies	study	NNS
cord-015021-pol2qm74	8886	5	included	include	VBD
cord-015021-pol2qm74	8886	6	the	the	DT
cord-015021-pol2qm74	8886	7	determination	determination	NN
cord-015021-pol2qm74	8886	8	of	of	IN
cord-015021-pol2qm74	8886	9	CD3	CD3	NNP
cord-015021-pol2qm74	8886	10	and	and	CC
cord-015021-pol2qm74	8886	11	CD4	CD4	NNP
cord-015021-pol2qm74	8886	12	,	,	,
cord-015021-pol2qm74	8886	13	Mac	Mac	NNP
cord-015021-pol2qm74	8886	14	-	-	HYPH
cord-015021-pol2qm74	8886	15	l	l	NNP
cord-015021-pol2qm74	8886	16	,	,	,
cord-015021-pol2qm74	8886	17	and	and	CC
cord-015021-pol2qm74	8886	18	Ig	Ig	NNP
cord-015021-pol2qm74	8886	19	bearing	bearing	NN
cord-015021-pol2qm74	8886	20	cells	cell	NNS
cord-015021-pol2qm74	8886	21	.	.	.
cord-015021-pol2qm74	8887	1	We	-PRON-	PRP
cord-015021-pol2qm74	8887	2	have	have	VBP
cord-015021-pol2qm74	8887	3	also	also	RB
cord-015021-pol2qm74	8887	4	begun	begin	VBN
cord-015021-pol2qm74	8887	5	to	to	TO
cord-015021-pol2qm74	8887	6	examine	examine	VB
cord-015021-pol2qm74	8887	7	the	the	DT
cord-015021-pol2qm74	8887	8	change	change	NN
cord-015021-pol2qm74	8887	9	in	in	IN
cord-015021-pol2qm74	8887	10	cell	cell	NN
cord-015021-pol2qm74	8887	11	surface	surface	NN
cord-015021-pol2qm74	8887	12	phenotype	phenotype	NN
cord-015021-pol2qm74	8887	13	and	and	CC
cord-015021-pol2qm74	8887	14	kinetics	kinetic	NNS
cord-015021-pol2qm74	8887	15	of	of	IN
cord-015021-pol2qm74	8887	16	recruitment	recruitment	NN
cord-015021-pol2qm74	8887	17	following	follow	VBG
cord-015021-pol2qm74	8887	18	the	the	DT
cord-015021-pol2qm74	8887	19	inclusion	inclusion	NN
cord-015021-pol2qm74	8887	20	of	of	IN
cord-015021-pol2qm74	8887	21	TGF	TGF	NNP
cord-015021-pol2qm74	8887	22	-	-	HYPH
cord-015021-pol2qm74	8887	23	beta	beta	NN
cord-015021-pol2qm74	8887	24	in	in	IN
cord-015021-pol2qm74	8887	25	the	the	DT
cord-015021-pol2qm74	8887	26	lipid	lipid	NN
cord-015021-pol2qm74	8887	27	microcylinders	microcylinder	NNS
cord-015021-pol2qm74	8887	28	.	.	.
cord-015021-pol2qm74	8888	1	Center	Center	NNP
cord-015021-pol2qm74	8888	2	for	for	IN
cord-015021-pol2qm74	8888	3	Biomolecular	Biomolecular	NNP
cord-015021-pol2qm74	8888	4	Science	Science	NNP
cord-015021-pol2qm74	8888	5	and	and	CC
cord-015021-pol2qm74	8888	6	Engineering	Engineering	NNP
cord-015021-pol2qm74	8888	7	,	,	,
cord-015021-pol2qm74	8888	8	Code	Code	NNP
cord-015021-pol2qm74	8888	9	6900	6900	CD
cord-015021-pol2qm74	8888	10	,	,	,
cord-015021-pol2qm74	8888	11	Naval	Naval	NNP
cord-015021-pol2qm74	8888	12	Research	Research	NNP
cord-015021-pol2qm74	8888	13	Laboratory	Laboratory	NNP
cord-015021-pol2qm74	8888	14	,	,	,
cord-015021-pol2qm74	8888	15	Washington	Washington	NNP
cord-015021-pol2qm74	8888	16	,	,	,
cord-015021-pol2qm74	8888	17	DC	DC	NNP
cord-015021-pol2qm74	8888	18	.	.	.
cord-015021-pol2qm74	8889	1	20375	20375	CD
cord-015021-pol2qm74	8889	2	-	-	SYM
cord-015021-pol2qm74	8889	3	5348	5348	CD
cord-015021-pol2qm74	8889	4	.	.	.
cord-015021-pol2qm74	8890	1	Expression	expression	NN
cord-015021-pol2qm74	8890	2	pattern	pattern	NN
cord-015021-pol2qm74	8890	3	of	of	IN
cord-015021-pol2qm74	8890	4	heat	heat	NN
cord-015021-pol2qm74	8890	5	shock	shock	NN
cord-015021-pol2qm74	8890	6	proteins	protein	NNS
cord-015021-pol2qm74	8890	7	in	in	IN
cord-015021-pol2qm74	8890	8	acute	acute	JJ
cord-015021-pol2qm74	8890	9	,	,	,
cord-015021-pol2qm74	8890	10	good	good	JJ
cord-015021-pol2qm74	8890	11	healing	healing	NN
cord-015021-pol2qm74	8890	12	and	and	CC
cord-015021-pol2qm74	8890	13	chronic	chronic	JJ
cord-015021-pol2qm74	8890	14	human	human	JJ
cord-015021-pol2qm74	8890	15	wound	wound	NN
cord-015021-pol2qm74	8890	16	tissue	tissue	NN
cord-015021-pol2qm74	8890	17	.	.	.
cord-015021-pol2qm74	8891	1	Abstract	Abstract	NNP
cord-015021-pol2qm74	8891	2	:	:	:
cord-015021-pol2qm74	8892	1	Wound	wound	JJ
cord-015021-pol2qm74	8892	2	healing	healing	NN
cord-015021-pol2qm74	8892	3	is	be	VBZ
cord-015021-pol2qm74	8892	4	a	a	DT
cord-015021-pol2qm74	8892	5	complex	complex	JJ
cord-015021-pol2qm74	8892	6	biologic	biologic	JJ
cord-015021-pol2qm74	8892	7	process	process	NN
cord-015021-pol2qm74	8892	8	that	that	WDT
cord-015021-pol2qm74	8892	9	is	be	VBZ
cord-015021-pol2qm74	8892	10	well	well	RB
cord-015021-pol2qm74	8892	11	characterized	characterize	VBN
cord-015021-pol2qm74	8892	12	at	at	IN
cord-015021-pol2qm74	8892	13	the	the	DT
cord-015021-pol2qm74	8892	14	histological	histological	JJ
cord-015021-pol2qm74	8892	15	level	level	NN
cord-015021-pol2qm74	8892	16	,	,	,
cord-015021-pol2qm74	8892	17	but	but	CC
cord-015021-pol2qm74	8892	18	its	-PRON-	PRP$
cord-015021-pol2qm74	8892	19	molecular	molecular	JJ
cord-015021-pol2qm74	8892	20	regulation	regulation	NN
cord-015021-pol2qm74	8892	21	is	be	VBZ
cord-015021-pol2qm74	8892	22	poorly	poorly	RB
cord-015021-pol2qm74	8892	23	understood	understand	VBN
cord-015021-pol2qm74	8892	24	.	.	.
cord-015021-pol2qm74	8893	1	After	after	IN
cord-015021-pol2qm74	8893	2	clot	clot	NN
cord-015021-pol2qm74	8893	3	formation	formation	NN
cord-015021-pol2qm74	8893	4	,	,	,
cord-015021-pol2qm74	8893	5	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8893	6	cells	cell	NNS
cord-015021-pol2qm74	8893	7	are	be	VBP
cord-015021-pol2qm74	8893	8	rapidly	rapidly	RB
cord-015021-pol2qm74	8893	9	drawn	draw	VBN
cord-015021-pol2qm74	8893	10	into	into	IN
cord-015021-pol2qm74	8893	11	the	the	DT
cord-015021-pol2qm74	8893	12	wound	wound	NN
cord-015021-pol2qm74	8893	13	,	,	,
cord-015021-pol2qm74	8893	14	followed	follow	VBN
cord-015021-pol2qm74	8893	15	by	by	IN
cord-015021-pol2qm74	8893	16	migration	migration	NN
cord-015021-pol2qm74	8893	17	of	of	IN
cord-015021-pol2qm74	8893	18	fibroblasts	fibroblast	NNS
cord-015021-pol2qm74	8893	19	and	and	CC
cord-015021-pol2qm74	8893	20	epithelial	epithelial	JJ
cord-015021-pol2qm74	8893	21	cells	cell	NNS
cord-015021-pol2qm74	8893	22	that	that	WDT
cord-015021-pol2qm74	8893	23	divide	divide	VBP
cord-015021-pol2qm74	8893	24	and	and	CC
cord-015021-pol2qm74	8893	25	repopulate	repopulate	VB
cord-015021-pol2qm74	8893	26	the	the	DT
cord-015021-pol2qm74	8893	27	wound	wound	NN
cord-015021-pol2qm74	8893	28	area	area	NN
cord-015021-pol2qm74	8893	29	.	.	.
cord-015021-pol2qm74	8894	1	During	during	IN
cord-015021-pol2qm74	8894	2	the	the	DT
cord-015021-pol2qm74	8894	3	last	last	JJ
cord-015021-pol2qm74	8894	4	decade	decade	NN
cord-015021-pol2qm74	8894	5	peptide	peptide	JJ
cord-015021-pol2qm74	8894	6	growth	growth	NN
cord-015021-pol2qm74	8894	7	factors	factor	NNS
cord-015021-pol2qm74	8894	8	and	and	CC
cord-015021-pol2qm74	8894	9	cytokine	cytokine	NN
cord-015021-pol2qm74	8894	10	are	be	VBP
cord-015021-pol2qm74	8894	11	thought	think	VBN
cord-015021-pol2qm74	8894	12	to	to	TO
cord-015021-pol2qm74	8894	13	play	play	VB
cord-015021-pol2qm74	8894	14	a	a	DT
cord-015021-pol2qm74	8894	15	key	key	JJ
cord-015021-pol2qm74	8894	16	role	role	NN
cord-015021-pol2qm74	8894	17	in	in	IN
cord-015021-pol2qm74	8894	18	initiating	initiate	VBG
cord-015021-pol2qm74	8894	19	and	and	CC
cord-015021-pol2qm74	8894	20	sustaining	sustain	VBG
cord-015021-pol2qm74	8894	21	the	the	DT
cord-015021-pol2qm74	8894	22	phase	phase	NN
cord-015021-pol2qm74	8894	23	of	of	IN
cord-015021-pol2qm74	8894	24	tissue	tissue	NN
cord-015021-pol2qm74	8894	25	repair	repair	NN
cord-015021-pol2qm74	8894	26	.	.	.
cord-015021-pol2qm74	8895	1	These	these	DT
cord-015021-pol2qm74	8895	2	factors	factor	NNS
cord-015021-pol2qm74	8895	3	which	which	WDT
cord-015021-pol2qm74	8895	4	are	be	VBP
cord-015021-pol2qm74	8895	5	released	release	VBN
cord-015021-pol2qm74	8895	6	from	from	IN
cord-015021-pol2qm74	8895	7	different	different	JJ
cord-015021-pol2qm74	8895	8	cells	cell	NNS
cord-015021-pol2qm74	8895	9	appear	appear	VBP
cord-015021-pol2qm74	8895	10	to	to	TO
cord-015021-pol2qm74	8895	11	initiate	initiate	VB
cord-015021-pol2qm74	8895	12	the	the	DT
cord-015021-pol2qm74	8895	13	cascade	cascade	NN
cord-015021-pol2qm74	8895	14	of	of	IN
cord-015021-pol2qm74	8895	15	events	event	NNS
cord-015021-pol2qm74	8895	16	that	that	WDT
cord-015021-pol2qm74	8895	17	lead	lead	VBP
cord-015021-pol2qm74	8895	18	to	to	IN
cord-015021-pol2qm74	8895	19	healing	healing	NN
cord-015021-pol2qm74	8895	20	.	.	.
cord-015021-pol2qm74	8896	1	Different	different	JJ
cord-015021-pol2qm74	8896	2	studys	study	NNS
cord-015021-pol2qm74	8896	3	described	describe	VBD
cord-015021-pol2qm74	8896	4	the	the	DT
cord-015021-pol2qm74	8896	5	rapid	rapid	JJ
cord-015021-pol2qm74	8896	6	activation	activation	NN
cord-015021-pol2qm74	8896	7	of	of	IN
cord-015021-pol2qm74	8896	8	a	a	DT
cord-015021-pol2qm74	8896	9	family	family	NN
cord-015021-pol2qm74	8896	10	of	of	IN
cord-015021-pol2qm74	8896	11	proteins	protein	NNS
cord-015021-pol2qm74	8896	12	,	,	,
cord-015021-pol2qm74	8896	13	named	name	VBN
cord-015021-pol2qm74	8896	14	heat	heat	NN
cord-015021-pol2qm74	8896	15	shock	shock	NN
cord-015021-pol2qm74	8896	16	proteins	protein	NNS
cord-015021-pol2qm74	8896	17	(	(	-LRB-
cord-015021-pol2qm74	8896	18	HSP	HSP	NNP
cord-015021-pol2qm74	8896	19	)	)	-RRB-
cord-015021-pol2qm74	8896	20	in	in	IN
cord-015021-pol2qm74	8896	21	differnt	differnt	NNS
cord-015021-pol2qm74	8896	22	tissue	tissue	NN
cord-015021-pol2qm74	8896	23	that	that	WDT
cord-015021-pol2qm74	8896	24	were	be	VBD
cord-015021-pol2qm74	8896	25	exposed	expose	VBN
cord-015021-pol2qm74	8896	26	to	to	IN
cord-015021-pol2qm74	8896	27	various	various	JJ
cord-015021-pol2qm74	8896	28	forms	form	NNS
cord-015021-pol2qm74	8896	29	of	of	IN
cord-015021-pol2qm74	8896	30	stress	stress	NN
cord-015021-pol2qm74	8896	31	(	(	-LRB-
cord-015021-pol2qm74	8896	32	heat	heat	NN
cord-015021-pol2qm74	8896	33	,	,	,
cord-015021-pol2qm74	8896	34	toxic	toxic	JJ
cord-015021-pol2qm74	8896	35	agents	agent	NNS
cord-015021-pol2qm74	8896	36	,	,	,
cord-015021-pol2qm74	8896	37	mechanical	mechanical	JJ
cord-015021-pol2qm74	8896	38	)	)	-RRB-
cord-015021-pol2qm74	8896	39	.	.	.
cord-015021-pol2qm74	8897	1	In	in	IN
cord-015021-pol2qm74	8897	2	this	this	DT
cord-015021-pol2qm74	8897	3	context	context	NN
cord-015021-pol2qm74	8897	4	HSP	HSP	NNP
cord-015021-pol2qm74	8897	5	's	's	POS
cord-015021-pol2qm74	8897	6	have	have	VBP
cord-015021-pol2qm74	8897	7	the	the	DT
cord-015021-pol2qm74	8897	8	ability	ability	NN
cord-015021-pol2qm74	8897	9	to	to	TO
cord-015021-pol2qm74	8897	10	regulate	regulate	VB
cord-015021-pol2qm74	8897	11	protein	protein	NN
cord-015021-pol2qm74	8897	12	folding	folding	NN
cord-015021-pol2qm74	8897	13	and	and	CC
cord-015021-pol2qm74	8897	14	assembly	assembly	NN
cord-015021-pol2qm74	8897	15	,	,	,
cord-015021-pol2qm74	8897	16	to	to	TO
cord-015021-pol2qm74	8897	17	transport	transport	VB
cord-015021-pol2qm74	8897	18	proteins	protein	NNS
cord-015021-pol2qm74	8897	19	across	across	IN
cord-015021-pol2qm74	8897	20	cytoplasm	cytoplasm	NN
cord-015021-pol2qm74	8897	21	and	and	CC
cord-015021-pol2qm74	8897	22	membranes	membrane	NNS
cord-015021-pol2qm74	8897	23	,	,	,
cord-015021-pol2qm74	8897	24	to	to	TO
cord-015021-pol2qm74	8897	25	disrupt	disrupt	VB
cord-015021-pol2qm74	8897	26	protein	protein	NN
cord-015021-pol2qm74	8897	27	complexes	complex	NNS
cord-015021-pol2qm74	8897	28	,	,	,
cord-015021-pol2qm74	8897	29	to	to	TO
cord-015021-pol2qm74	8897	30	stabilize	stabilize	VB
cord-015021-pol2qm74	8897	31	,	,	,
cord-015021-pol2qm74	8897	32	degrade	degrade	VB
cord-015021-pol2qm74	8897	33	and	and	CC
cord-015021-pol2qm74	8897	34	regulate	regulate	VB
cord-015021-pol2qm74	8897	35	the	the	DT
cord-015021-pol2qm74	8897	36	synthesis	synthesis	NN
cord-015021-pol2qm74	8897	37	of	of	IN
cord-015021-pol2qm74	8897	38	proteins	protein	NNS
cord-015021-pol2qm74	8897	39	and	and	CC
cord-015021-pol2qm74	8897	40	to	to	TO
cord-015021-pol2qm74	8897	41	take	take	VB
cord-015021-pol2qm74	8897	42	part	part	NN
cord-015021-pol2qm74	8897	43	in	in	IN
cord-015021-pol2qm74	8897	44	DNA	dna	NN
cord-015021-pol2qm74	8897	45	replication	replication	NN
cord-015021-pol2qm74	8897	46	and	and	CC
cord-015021-pol2qm74	8897	47	repair	repair	NN
cord-015021-pol2qm74	8897	48	.	.	.
cord-015021-pol2qm74	8898	1	We	-PRON-	PRP
cord-015021-pol2qm74	8898	2	now	now	RB
cord-015021-pol2qm74	8898	3	attempted	attempt	VBD
cord-015021-pol2qm74	8898	4	to	to	TO
cord-015021-pol2qm74	8898	5	find	find	VB
cord-015021-pol2qm74	8898	6	out	out	RP
cord-015021-pol2qm74	8898	7	if	if	IN
cord-015021-pol2qm74	8898	8	HSP	HSP	NNP
cord-015021-pol2qm74	8898	9	-	-	HYPH
cord-015021-pol2qm74	8898	10	gene	gene	NN
cord-015021-pol2qm74	8898	11	activation	activation	NN
cord-015021-pol2qm74	8898	12	is	be	VBZ
cord-015021-pol2qm74	8898	13	also	also	RB
cord-015021-pol2qm74	8898	14	involved	involve	VBN
cord-015021-pol2qm74	8898	15	in	in	IN
cord-015021-pol2qm74	8898	16	injury	injury	NN
cord-015021-pol2qm74	8898	17	and	and	CC
cord-015021-pol2qm74	8898	18	wound	wound	VB
cord-015021-pol2qm74	8898	19	healing	healing	NN
cord-015021-pol2qm74	8898	20	,	,	,
cord-015021-pol2qm74	8898	21	which	which	WDT
cord-015021-pol2qm74	8898	22	likewise	likewise	RB
cord-015021-pol2qm74	8898	23	resemble	resemble	VBP
cord-015021-pol2qm74	8898	24	a	a	DT
cord-015021-pol2qm74	8898	25	stress	stress	NN
cord-015021-pol2qm74	8898	26	situation	situation	NN
cord-015021-pol2qm74	8898	27	for	for	IN
cord-015021-pol2qm74	8898	28	cells	cell	NNS
cord-015021-pol2qm74	8898	29	.	.	.
cord-015021-pol2qm74	8899	1	Therefore	therefore	RB
cord-015021-pol2qm74	8899	2	we	-PRON-	PRP
cord-015021-pol2qm74	8899	3	collected	collect	VBD
cord-015021-pol2qm74	8899	4	tissue	tissue	NN
cord-015021-pol2qm74	8899	5	samples	sample	NNS
cord-015021-pol2qm74	8899	6	during	during	IN
cord-015021-pol2qm74	8899	7	operation	operation	NN
cord-015021-pol2qm74	8899	8	and	and	CC
cord-015021-pol2qm74	8899	9	single	single	JJ
cord-015021-pol2qm74	8899	10	biopsies	biopsy	NNS
cord-015021-pol2qm74	8899	11	from	from	IN
cord-015021-pol2qm74	8899	12	chronic	chronic	JJ
cord-015021-pol2qm74	8899	13	wounds	wound	NNS
cord-015021-pol2qm74	8899	14	(	(	-LRB-
cord-015021-pol2qm74	8899	15	Decubitus	Decubitus	NNP
cord-015021-pol2qm74	8899	16	for	for	IN
cord-015021-pol2qm74	8899	17	example	example	NN
cord-015021-pol2qm74	8899	18	)	)	-RRB-
cord-015021-pol2qm74	8899	19	and	and	CC
cord-015021-pol2qm74	8899	20	granulation	granulation	NN
cord-015021-pol2qm74	8899	21	tissue	tissue	NN
cord-015021-pol2qm74	8899	22	.	.	.
cord-015021-pol2qm74	8900	1	After	after	IN
cord-015021-pol2qm74	8900	2	RNA	rna	NN
cord-015021-pol2qm74	8900	3	preparation	preparation	NN
cord-015021-pol2qm74	8900	4	from	from	IN
cord-015021-pol2qm74	8900	5	these	these	DT
cord-015021-pol2qm74	8900	6	samples	sample	NNS
cord-015021-pol2qm74	8900	7	we	-PRON-	PRP
cord-015021-pol2qm74	8900	8	used	use	VBD
cord-015021-pol2qm74	8900	9	RNA	RNA	NNP
cord-015021-pol2qm74	8900	10	-	-	HYPH
cord-015021-pol2qm74	8900	11	PCR	PCR	NNP
cord-015021-pol2qm74	8900	12	and	and	CC
cord-015021-pol2qm74	8900	13	Nothern	nothern	JJ
cord-015021-pol2qm74	8900	14	analysis	analysis	NN
cord-015021-pol2qm74	8900	15	to	to	TO
cord-015021-pol2qm74	8900	16	study	study	VB
cord-015021-pol2qm74	8900	17	the	the	DT
cord-015021-pol2qm74	8900	18	expression	expression	NN
cord-015021-pol2qm74	8900	19	of	of	IN
cord-015021-pol2qm74	8900	20	Objectives	Objectives	NNPS
cord-015021-pol2qm74	8900	21	of	of	IN
cord-015021-pol2qm74	8900	22	the	the	DT
cord-015021-pol2qm74	8900	23	study	study	NN
cord-015021-pol2qm74	8900	24	Chronic	Chronic	NNP
cord-015021-pol2qm74	8900	25	,	,	,
cord-015021-pol2qm74	8900	26	non	non	JJ
cord-015021-pol2qm74	8900	27	-	-	JJ
cord-015021-pol2qm74	8900	28	healing	healing	JJ
cord-015021-pol2qm74	8900	29	cutaneous	cutaneous	JJ
cord-015021-pol2qm74	8900	30	tflcers	tflcer	NNS
cord-015021-pol2qm74	8900	31	are	be	VBP
cord-015021-pol2qm74	8900	32	a	a	DT
cord-015021-pol2qm74	8900	33	challenging	challenge	VBG
cord-015021-pol2qm74	8900	34	clinical	clinical	JJ
cord-015021-pol2qm74	8900	35	and	and	CC
cord-015021-pol2qm74	8900	36	socioeconomic	socioeconomic	JJ
cord-015021-pol2qm74	8900	37	problem	problem	NN
cord-015021-pol2qm74	8900	38	.	.	.
cord-015021-pol2qm74	8901	1	Several	several	JJ
cord-015021-pol2qm74	8901	2	animal	animal	NN
cord-015021-pol2qm74	8901	3	studies	study	NNS
cord-015021-pol2qm74	8901	4	have	have	VBP
cord-015021-pol2qm74	8901	5	shown	show	VBN
cord-015021-pol2qm74	8901	6	that	that	IN
cord-015021-pol2qm74	8901	7	cytukines	cytukine	NNS
cord-015021-pol2qm74	8901	8	(	(	-LRB-
cord-015021-pol2qm74	8901	9	e.g.	e.g.	RB
cord-015021-pol2qm74	8901	10	EGF	EGF	NNP
cord-015021-pol2qm74	8901	11	,	,	,
cord-015021-pol2qm74	8901	12	PDGF	PDGF	NNP
cord-015021-pol2qm74	8901	13	,	,	,
cord-015021-pol2qm74	8901	14	FGF	FGF	NNP
cord-015021-pol2qm74	8901	15	,	,	,
cord-015021-pol2qm74	8901	16	TGFB	TGFB	NNP
cord-015021-pol2qm74	8901	17	)	)	-RRB-
cord-015021-pol2qm74	8901	18	accelerate	accelerate	VBP
cord-015021-pol2qm74	8901	19	the	the	DT
cord-015021-pol2qm74	8901	20	healing	healing	NN
cord-015021-pol2qm74	8901	21	process	process	NN
cord-015021-pol2qm74	8901	22	and	and	CC
cord-015021-pol2qm74	8901	23	tissue	tissue	NN
cord-015021-pol2qm74	8901	24	repair	repair	NN
cord-015021-pol2qm74	8901	25	in	in	IN
cord-015021-pol2qm74	8901	26	general	general	NN
cord-015021-pol2qm74	8901	27	.	.	.
cord-015021-pol2qm74	8902	1	Results	result	NNS
cord-015021-pol2qm74	8902	2	from	from	IN
cord-015021-pol2qm74	8902	3	first	first	JJ
cord-015021-pol2qm74	8902	4	clinical	clinical	JJ
cord-015021-pol2qm74	8902	5	trials	trial	NNS
cord-015021-pol2qm74	8902	6	indicate	indicate	VBP
cord-015021-pol2qm74	8902	7	a	a	DT
cord-015021-pol2qm74	8902	8	promising	promising	JJ
cord-015021-pol2qm74	8902	9	value	value	NN
cord-015021-pol2qm74	8902	10	of	of	IN
cord-015021-pol2qm74	8902	11	cytokines	cytokine	NNS
cord-015021-pol2qm74	8902	12	in	in	IN
cord-015021-pol2qm74	8902	13	the	the	DT
cord-015021-pol2qm74	8902	14	treatment	treatment	NN
cord-015021-pol2qm74	8902	15	of	of	IN
cord-015021-pol2qm74	8902	16	chronic	chronic	JJ
cord-015021-pol2qm74	8902	17	non	non	JJ
cord-015021-pol2qm74	8902	18	-	-	JJ
cord-015021-pol2qm74	8902	19	healing	healing	JJ
cord-015021-pol2qm74	8902	20	diabetic	diabetic	JJ
cord-015021-pol2qm74	8902	21	and	and	CC
cord-015021-pol2qm74	8902	22	venous	venous	JJ
cord-015021-pol2qm74	8902	23	ulcers	ulcer	NNS
cord-015021-pol2qm74	8902	24	.	.	.
cord-015021-pol2qm74	8903	1	Recent	recent	JJ
cord-015021-pol2qm74	8903	2	reports	report	NNS
cord-015021-pol2qm74	8903	3	in	in	IN
cord-015021-pol2qm74	8903	4	the	the	DT
cord-015021-pol2qm74	8903	5	literature	literature	NN
cord-015021-pol2qm74	8903	6	indicate	indicate	VBP
cord-015021-pol2qm74	8903	7	that	that	IN
cord-015021-pol2qm74	8903	8	the	the	DT
cord-015021-pol2qm74	8903	9	biological	biological	JJ
cord-015021-pol2qm74	8903	10	activity	activity	NN
cord-015021-pol2qm74	8903	11	of	of	IN
cord-015021-pol2qm74	8903	12	the	the	DT
cord-015021-pol2qm74	8903	13	solution	solution	NN
cord-015021-pol2qm74	8903	14	of	of	IN
cord-015021-pol2qm74	8903	15	platlet	platlet	NN
cord-015021-pol2qm74	8903	16	derived	derive	VBN
cord-015021-pol2qm74	8903	17	wound	wound	NN
cord-015021-pol2qm74	8903	18	healing	healing	NN
cord-015021-pol2qm74	8903	19	formula	formula	NN
cord-015021-pol2qm74	8903	20	(	(	-LRB-
cord-015021-pol2qm74	8903	21	PDWt~	pdwt~	RB
cord-015021-pol2qm74	8903	22	)	)	-RRB-
cord-015021-pol2qm74	8903	23	released	release	VBN
cord-015021-pol2qm74	8903	24	from	from	IN
cord-015021-pol2qm74	8903	25	c~-granules	c~-granule	NNS
cord-015021-pol2qm74	8903	26	(	(	-LRB-
cord-015021-pol2qm74	8903	27	mainly	mainly	RB
cord-015021-pol2qm74	8903	28	PDGF	PDGF	NNP
cord-015021-pol2qm74	8903	29	&	&	CC
cord-015021-pol2qm74	8903	30	TGFI~	TGFI~	NNP
cord-015021-pol2qm74	8903	31	)	)	-RRB-
cord-015021-pol2qm74	8903	32	is	be	VBZ
cord-015021-pol2qm74	8903	33	greater	great	JJR
cord-015021-pol2qm74	8903	34	than	than	IN
cord-015021-pol2qm74	8903	35	the	the	DT
cord-015021-pol2qm74	8903	36	activity	activity	NN
cord-015021-pol2qm74	8903	37	of	of	IN
cord-015021-pol2qm74	8903	38	the	the	DT
cord-015021-pol2qm74	8903	39	recombiant	recombiant	JJ
cord-015021-pol2qm74	8903	40	single	single	JJ
cord-015021-pol2qm74	8903	41	factors	factor	NNS
cord-015021-pol2qm74	8903	42	like	like	IN
cord-015021-pol2qm74	8903	43	e.g.	e.g.	RB
cord-015021-pol2qm74	8903	44	PDGF	PDGF	NNP
cord-015021-pol2qm74	8903	45	-	-	HYPH
cord-015021-pol2qm74	8903	46	BB	BB	NNP
cord-015021-pol2qm74	8904	1	(	(	-LRB-
cord-015021-pol2qm74	8904	2	Robson	Robson	NNP
cord-015021-pol2qm74	8904	3	,	,	,
cord-015021-pol2qm74	8904	4	Lancet	Lancet	NNP
cord-015021-pol2qm74	8904	5	1992	1992	CD
cord-015021-pol2qm74	8904	6	)	)	-RRB-
cord-015021-pol2qm74	8904	7	.	.	.
cord-015021-pol2qm74	8905	1	The	the	DT
cord-015021-pol2qm74	8905	2	aim	aim	NN
cord-015021-pol2qm74	8905	3	of	of	IN
cord-015021-pol2qm74	8905	4	our	-PRON-	PRP$
cord-015021-pol2qm74	8905	5	study	study	NN
cord-015021-pol2qm74	8905	6	was	be	VBD
cord-015021-pol2qm74	8905	7	to	to	TO
cord-015021-pol2qm74	8905	8	determine	determine	VB
cord-015021-pol2qm74	8905	9	whether	whether	IN
cord-015021-pol2qm74	8905	10	a	a	DT
cord-015021-pol2qm74	8905	11	correlation	correlation	NN
cord-015021-pol2qm74	8905	12	exits	exit	VBZ
cord-015021-pol2qm74	8905	13	between	between	IN
cord-015021-pol2qm74	8905	14	the	the	DT
cord-015021-pol2qm74	8905	15	concentration	concentration	NN
cord-015021-pol2qm74	8905	16	of	of	IN
cord-015021-pol2qm74	8905	17	TGFI~	TGFI~	NNP
cord-015021-pol2qm74	8905	18	&	&	CC
cord-015021-pol2qm74	8905	19	PDGF	PDGF	NNP
cord-015021-pol2qm74	8905	20	and	and	CC
cord-015021-pol2qm74	8905	21	the	the	DT
cord-015021-pol2qm74	8905	22	time	time	NN
cord-015021-pol2qm74	8905	23	course	course	NN
cord-015021-pol2qm74	8905	24	of	of	IN
cord-015021-pol2qm74	8905	25	wound	wound	NN
cord-015021-pol2qm74	8905	26	healing	healing	NN
cord-015021-pol2qm74	8905	27	.	.	.
cord-015021-pol2qm74	8906	1	Materials	material	NNS
cord-015021-pol2qm74	8906	2	and	and	CC
cord-015021-pol2qm74	8906	3	methods	method	NNS
cord-015021-pol2qm74	8906	4	PDWHF	PDWHF	NNP
cord-015021-pol2qm74	8906	5	was	be	VBD
cord-015021-pol2qm74	8906	6	prepared	prepare	VBN
cord-015021-pol2qm74	8906	7	from	from	IN
cord-015021-pol2qm74	8906	8	200ml	200ml	CD
cord-015021-pol2qm74	8906	9	of	of	IN
cord-015021-pol2qm74	8906	10	auto]ogous	auto]ogous	JJ
cord-015021-pol2qm74	8906	11	patient	patient	JJ
cord-015021-pol2qm74	8906	12	blood	blood	NN
cord-015021-pol2qm74	8906	13	and	and	CC
cord-015021-pol2qm74	8906	14	diluted	dilute	VBN
cord-015021-pol2qm74	8906	15	with	with	IN
cord-015021-pol2qm74	8906	16	a	a	DT
cord-015021-pol2qm74	8906	17	special	special	JJ
cord-015021-pol2qm74	8906	18	buffer	buffer	NN
cord-015021-pol2qm74	8906	19	to	to	IN
cord-015021-pol2qm74	8906	20	a	a	DT
cord-015021-pol2qm74	8906	21	final	final	JJ
cord-015021-pol2qm74	8906	22	concentration	concentration	NN
cord-015021-pol2qm74	8906	23	of	of	IN
cord-015021-pol2qm74	8906	24	30	30	CD
cord-015021-pol2qm74	8906	25	ng	ng	NN
cord-015021-pol2qm74	8906	26	/	/	SYM
cord-015021-pol2qm74	8906	27	ml	ml	NN
cord-015021-pol2qm74	8906	28	g	g	NNP
cord-015021-pol2qm74	8906	29	-	-	HYPH
cord-015021-pol2qm74	8906	30	thromboglobulin	thromboglobulin	NNP
cord-015021-pol2qm74	8906	31	.	.	.
cord-015021-pol2qm74	8907	1	The	the	DT
cord-015021-pol2qm74	8907	2	concentrations	concentration	NNS
cord-015021-pol2qm74	8907	3	of	of	IN
cord-015021-pol2qm74	8907	4	PDGF	PDGF	NNP
cord-015021-pol2qm74	8907	5	and	and	CC
cord-015021-pol2qm74	8907	6	TGFg	TGFg	NNP
cord-015021-pol2qm74	8907	7	were	be	VBD
cord-015021-pol2qm74	8907	8	determined	determine	VBN
cord-015021-pol2qm74	8907	9	by	by	IN
cord-015021-pol2qm74	8907	10	ELISA	ELISA	NNP
cord-015021-pol2qm74	8907	11	-	-	HYPH
cord-015021-pol2qm74	8907	12	tests	test	NNS
cord-015021-pol2qm74	8907	13	developed	develop	VBN
cord-015021-pol2qm74	8907	14	in	in	IN
cord-015021-pol2qm74	8907	15	our	-PRON-	PRP$
cord-015021-pol2qm74	8907	16	laboratory	laboratory	NN
cord-015021-pol2qm74	8907	17	.	.	.
cord-015021-pol2qm74	8908	1	22	22	CD
cord-015021-pol2qm74	8908	2	patients	patient	NNS
cord-015021-pol2qm74	8908	3	with	with	IN
cord-015021-pol2qm74	8908	4	chronic	chronic	JJ
cord-015021-pol2qm74	8908	5	non	non	JJ
cord-015021-pol2qm74	8908	6	-	-	JJ
cord-015021-pol2qm74	8908	7	healing	healing	JJ
cord-015021-pol2qm74	8908	8	ulcers	ulcer	NNS
cord-015021-pol2qm74	8908	9	have	have	VBP
cord-015021-pol2qm74	8908	10	been	be	VBN
cord-015021-pol2qm74	8908	11	evaluated	evaluate	VBN
cord-015021-pol2qm74	8908	12	alter	alter	JJ
cord-015021-pol2qm74	8908	13	treatment	treatment	NN
cord-015021-pol2qm74	8908	14	by	by	IN
cord-015021-pol2qm74	8908	15	topical	topical	JJ
cord-015021-pol2qm74	8908	16	application	application	NN
cord-015021-pol2qm74	8908	17	of	of	IN
cord-015021-pol2qm74	8908	18	PDWHF	PDWHF	NNP
cord-015021-pol2qm74	8908	19	.	.	.
cord-015021-pol2qm74	8909	1	PDFG	PDFG	NNP
cord-015021-pol2qm74	8909	2	and	and	CC
cord-015021-pol2qm74	8909	3	TGFf~	TGFf~	NNP
cord-015021-pol2qm74	8909	4	concentrations	concentration	NNS
cord-015021-pol2qm74	8909	5	of	of	IN
cord-015021-pol2qm74	8909	6	the	the	DT
cord-015021-pol2qm74	8909	7	topical	topical	JJ
cord-015021-pol2qm74	8909	8	solution	solution	NN
cord-015021-pol2qm74	8909	9	were	be	VBD
cord-015021-pol2qm74	8909	10	measured	measure	VBN
cord-015021-pol2qm74	8909	11	and	and	CC
cord-015021-pol2qm74	8909	12	two	two	CD
cord-015021-pol2qm74	8909	13	patient	patient	JJ
cord-015021-pol2qm74	8909	14	groups	group	NNS
cord-015021-pol2qm74	8909	15	formed	form	VBN
cord-015021-pol2qm74	8909	16	for	for	IN
cord-015021-pol2qm74	8909	17	analysis	analysis	NN
cord-015021-pol2qm74	8910	1	The	the	DT
cord-015021-pol2qm74	8910	2	time	time	NN
cord-015021-pol2qm74	8910	3	course	course	NN
cord-015021-pol2qm74	8910	4	of	of	IN
cord-015021-pol2qm74	8910	5	wound	wound	NN
cord-015021-pol2qm74	8910	6	healing	healing	NN
cord-015021-pol2qm74	8910	7	was	be	VBD
cord-015021-pol2qm74	8910	8	regularly	regularly	RB
cord-015021-pol2qm74	8910	9	and	and	CC
cord-015021-pol2qm74	8910	10	meticulously	meticulously	RB
cord-015021-pol2qm74	8910	11	documented	document	VBN
cord-015021-pol2qm74	8910	12	and	and	CC
cord-015021-pol2qm74	8910	13	evaluated	evaluate	VBN
cord-015021-pol2qm74	8910	14	by	by	IN
cord-015021-pol2qm74	8910	15	photography	photography	NN
cord-015021-pol2qm74	8910	16	and	and	CC
cord-015021-pol2qm74	8910	17	casting	casting	NN
cord-015021-pol2qm74	8910	18	.	.	.
cord-015021-pol2qm74	8911	1	The	the	DT
cord-015021-pol2qm74	8911	2	time	time	NN
cord-015021-pol2qm74	8911	3	from	from	IN
cord-015021-pol2qm74	8911	4	initiation	initiation	NN
cord-015021-pol2qm74	8911	5	of	of	IN
cord-015021-pol2qm74	8911	6	treatment	treatment	NN
cord-015021-pol2qm74	8911	7	instil	instil	VBP
cord-015021-pol2qm74	8911	8	o	o	NN
cord-015021-pol2qm74	8911	9	wound	wound	NN
cord-015021-pol2qm74	8911	10	volume	volume	NN
cord-015021-pol2qm74	8911	11	reduction	reduction	NN
cord-015021-pol2qm74	8911	12	to	to	IN
cord-015021-pol2qm74	8911	13	50	50	CD
cord-015021-pol2qm74	8911	14	go	go	NN
cord-015021-pol2qm74	8911	15	of	of	IN
cord-015021-pol2qm74	8911	16	the	the	DT
cord-015021-pol2qm74	8911	17	origional	origional	JJ
cord-015021-pol2qm74	8911	18	size	size	NN
cord-015021-pol2qm74	8911	19	(	(	-LRB-
cord-015021-pol2qm74	8911	20	T50	T50	NNP
cord-015021-pol2qm74	8911	21	%	%	NN
cord-015021-pol2qm74	8911	22	)	)	-RRB-
cord-015021-pol2qm74	8911	23	was	be	VBD
cord-015021-pol2qm74	8911	24	noted•	noted•	NNP
cord-015021-pol2qm74	8911	25	Results	result	NNS
cord-015021-pol2qm74	8911	26	:	:	:
cord-015021-pol2qm74	8912	1	Healing	healing	NN
cord-015021-pol2qm74	8912	2	of	of	IN
cord-015021-pol2qm74	8912	3	extensive	extensive	JJ
cord-015021-pol2qm74	8912	4	burn	burn	NN
cord-015021-pol2qm74	8912	5	wounds	wound	NNS
cord-015021-pol2qm74	8912	6	can	can	MD
cord-015021-pol2qm74	8912	7	be	be	VB
cord-015021-pol2qm74	8912	8	accelerated	accelerate	VBN
cord-015021-pol2qm74	8912	9	by	by	IN
cord-015021-pol2qm74	8912	10	grafting	graft	VBG
cord-015021-pol2qm74	8912	11	cultured	cultured	JJ
cord-015021-pol2qm74	8912	12	autologous	autologous	JJ
cord-015021-pol2qm74	8912	13	or	or	CC
cord-015021-pol2qm74	8912	14	allogeneic	allogeneic	NN
cord-015021-pol2qm74	8912	15	keratinocytes	keratinocyte	NNS
cord-015021-pol2qm74	8912	16	.	.	.
cord-015021-pol2qm74	8913	1	The	the	DT
cord-015021-pol2qm74	8913	2	stimulation	stimulation	NN
cord-015021-pol2qm74	8913	3	of	of	IN
cord-015021-pol2qm74	8913	4	granulation	granulation	NN
cord-015021-pol2qm74	8913	5	tissue	tissue	NN
cord-015021-pol2qm74	8913	6	formation	formation	NN
cord-015021-pol2qm74	8913	7	and	and	CC
cord-015021-pol2qm74	8913	8	reepithelialization	reepithelialization	NN
cord-015021-pol2qm74	8913	9	is	be	VBZ
cord-015021-pol2qm74	8913	10	presumably	presumably	RB
cord-015021-pol2qm74	8913	11	based	base	VBN
cord-015021-pol2qm74	8913	12	on	on	IN
cord-015021-pol2qm74	8913	13	growth	growth	NN
cord-015021-pol2qm74	8913	14	factors	factor	NNS
cord-015021-pol2qm74	8913	15	and	and	CC
cord-015021-pol2qm74	8913	16	cytokines	cytokine	NNS
cord-015021-pol2qm74	8913	17	released	release	VBN
cord-015021-pol2qm74	8913	18	by	by	IN
cord-015021-pol2qm74	8913	19	keratinocytes	keratinocyte	NNS
cord-015021-pol2qm74	8913	20	.	.	.
cord-015021-pol2qm74	8914	1	We	-PRON-	PRP
cord-015021-pol2qm74	8914	2	wanted	want	VBD
cord-015021-pol2qm74	8914	3	to	to	TO
cord-015021-pol2qm74	8914	4	prove	prove	VB
cord-015021-pol2qm74	8914	5	this	this	DT
cord-015021-pol2qm74	8914	6	hypothesis	hypothesis	NN
cord-015021-pol2qm74	8914	7	by	by	IN
cord-015021-pol2qm74	8914	8	investigating	investigate	VBG
cord-015021-pol2qm74	8914	9	the	the	DT
cord-015021-pol2qm74	8914	10	bFGF	bfgf	JJ
cord-015021-pol2qm74	8914	11	expression	expression	NN
cord-015021-pol2qm74	8914	12	during	during	IN
cord-015021-pol2qm74	8914	13	wound	wound	NN
cord-015021-pol2qm74	8914	14	development	development	NN
cord-015021-pol2qm74	8914	15	,	,	,
cord-015021-pol2qm74	8914	16	bFGF	bfgf	NN
cord-015021-pol2qm74	8914	17	is	be	VBZ
cord-015021-pol2qm74	8914	18	mainly	mainly	RB
cord-015021-pol2qm74	8914	19	described	describe	VBN
cord-015021-pol2qm74	8914	20	as	as	IN
cord-015021-pol2qm74	8914	21	an	an	DT
cord-015021-pol2qm74	8914	22	angiogenic	angiogenic	JJ
cord-015021-pol2qm74	8914	23	protein	protein	NN
cord-015021-pol2qm74	8914	24	with	with	IN
cord-015021-pol2qm74	8914	25	mitogenic	mitogenic	JJ
cord-015021-pol2qm74	8914	26	activity	activity	NN
cord-015021-pol2qm74	8914	27	on	on	IN
cord-015021-pol2qm74	8914	28	various	various	JJ
cord-015021-pol2qm74	8914	29	mesodermal	mesodermal	JJ
cord-015021-pol2qm74	8914	30	and	and	CC
cord-015021-pol2qm74	8914	31	ectodermal	ectodermal	JJ
cord-015021-pol2qm74	8914	32	cell	cell	NN
cord-015021-pol2qm74	8914	33	types	type	NNS
cord-015021-pol2qm74	8914	34	pointing	point	VBG
cord-015021-pol2qm74	8914	35	to	to	IN
cord-015021-pol2qm74	8914	36	its	-PRON-	PRP$
cord-015021-pol2qm74	8914	37	stimulating	stimulating	JJ
cord-015021-pol2qm74	8914	38	potential	potential	NN
cord-015021-pol2qm74	8914	39	in	in	IN
cord-015021-pol2qm74	8914	40	wound	wound	NN
cord-015021-pol2qm74	8914	41	heating	heating	NN
cord-015021-pol2qm74	8914	42	.	.	.
cord-015021-pol2qm74	8915	1	In	in	IN
cord-015021-pol2qm74	8915	2	the	the	DT
cord-015021-pol2qm74	8915	3	present	present	JJ
cord-015021-pol2qm74	8915	4	study	study	NN
cord-015021-pol2qm74	8915	5	we	-PRON-	PRP
cord-015021-pol2qm74	8915	6	compared	compare	VBD
cord-015021-pol2qm74	8915	7	the	the	DT
cord-015021-pol2qm74	8915	8	pattern	pattern	NN
cord-015021-pol2qm74	8915	9	of	of	IN
cord-015021-pol2qm74	8915	10	human	human	NN
cord-015021-pol2qm74	8915	11	bFGF	bfgf	NN
cord-015021-pol2qm74	8915	12	m	m	NNP
cord-015021-pol2qm74	8915	13	-	-	HYPH
cord-015021-pol2qm74	8915	14	RNA	RNA	NNP
cord-015021-pol2qm74	8915	15	expression	expression	NN
cord-015021-pol2qm74	8915	16	and	and	CC
cord-015021-pol2qm74	8915	17	the	the	DT
cord-015021-pol2qm74	8915	18	localization	localization	NN
cord-015021-pol2qm74	8915	19	of	of	IN
cord-015021-pol2qm74	8915	20	bFGF	bfgf	NN
cord-015021-pol2qm74	8915	21	protein	protein	NN
cord-015021-pol2qm74	8915	22	during	during	IN
cord-015021-pol2qm74	8915	23	the	the	DT
cord-015021-pol2qm74	8915	24	first	first	JJ
cord-015021-pol2qm74	8915	25	days	day	NNS
cord-015021-pol2qm74	8915	26	of	of	IN
cord-015021-pol2qm74	8915	27	wound	wound	NN
cord-015021-pol2qm74	8915	28	healing	healing	NN
cord-015021-pol2qm74	8915	29	.	.	.
cord-015021-pol2qm74	8916	1	Biopsies	biopsy	NNS
cord-015021-pol2qm74	8916	2	were	be	VBD
cord-015021-pol2qm74	8916	3	taken	take	VBN
cord-015021-pol2qm74	8916	4	from	from	IN
cord-015021-pol2qm74	8916	5	5	5	CD
cord-015021-pol2qm74	8916	6	juvenile	juvenile	JJ
cord-015021-pol2qm74	8916	7	human	human	JJ
cord-015021-pol2qm74	8916	8	bum	bum	NN
cord-015021-pol2qm74	8916	9	patients	patient	NNS
cord-015021-pol2qm74	8916	10	,	,	,
cord-015021-pol2qm74	8916	11	immediately	immediately	RB
cord-015021-pol2qm74	8916	12	after	after	IN
cord-015021-pol2qm74	8916	13	wound	wind	VBD
cord-015021-pol2qm74	8916	14	debridemerit	debridemerit	NNP
cord-015021-pol2qm74	8916	15	mad	mad	JJ
cord-015021-pol2qm74	8916	16	on	on	IN
cord-015021-pol2qm74	8916	17	day	day	NN
cord-015021-pol2qm74	8916	18	8	8	CD
cord-015021-pol2qm74	8916	19	after	after	IN
cord-015021-pol2qm74	8916	20	transplantation	transplantation	NN
cord-015021-pol2qm74	8916	21	of	of	IN
cord-015021-pol2qm74	8916	22	cultured	cultured	JJ
cord-015021-pol2qm74	8916	23	allografts	allograft	NNS
cord-015021-pol2qm74	8916	24	.	.	.
cord-015021-pol2qm74	8917	1	Biopsies	biopsy	NNS
cord-015021-pol2qm74	8917	2	were	be	VBD
cord-015021-pol2qm74	8917	3	snap	snap	VB
cord-015021-pol2qm74	8917	4	frozen	freeze	VBN
cord-015021-pol2qm74	8917	5	and	and	CC
cord-015021-pol2qm74	8917	6	cryosected	cryosected	JJ
cord-015021-pol2qm74	8917	7	.	.	.
cord-015021-pol2qm74	8918	1	The	the	DT
cord-015021-pol2qm74	8918	2	pattern	pattern	NN
cord-015021-pol2qm74	8918	3	of	of	IN
cord-015021-pol2qm74	8918	4	bFGF	bfgf	JJ
cord-015021-pol2qm74	8918	5	expression	expression	NN
cord-015021-pol2qm74	8918	6	was	be	VBD
cord-015021-pol2qm74	8918	7	assessed	assess	VBN
cord-015021-pol2qm74	8918	8	by	by	IN
cord-015021-pol2qm74	8918	9	in	in	IN
cord-015021-pol2qm74	8918	10	situ	situ	JJ
cord-015021-pol2qm74	8918	11	hybridization	hybridization	NN
cord-015021-pol2qm74	8918	12	of	of	IN
cord-015021-pol2qm74	8918	13	the	the	DT
cord-015021-pol2qm74	8918	14	bFGF	bfgf	NN
cord-015021-pol2qm74	8918	15	m	m	NNP
cord-015021-pol2qm74	8918	16	-	-	HYPH
cord-015021-pol2qm74	8918	17	RNA	RNA	NNP
cord-015021-pol2qm74	8918	18	with	with	IN
cord-015021-pol2qm74	8918	19	a	a	DT
cord-015021-pol2qm74	8918	20	digoxigenin	digoxigenin	NN
cord-015021-pol2qm74	8918	21	-	-	HYPH
cord-015021-pol2qm74	8918	22	labelled	label	VBN
cord-015021-pol2qm74	8918	23	antisense	antisense	NN
cord-015021-pol2qm74	8918	24	-	-	HYPH
cord-015021-pol2qm74	8918	25	RNA	RNA	NNP
cord-015021-pol2qm74	8918	26	and	and	CC
cord-015021-pol2qm74	8918	27	the	the	DT
cord-015021-pol2qm74	8918	28	parallel	parallel	JJ
cord-015021-pol2qm74	8918	29	detection	detection	NN
cord-015021-pol2qm74	8918	30	of	of	IN
cord-015021-pol2qm74	8918	31	the	the	DT
cord-015021-pol2qm74	8918	32	mature	mature	JJ
cord-015021-pol2qm74	8918	33	protein	protein	NN
cord-015021-pol2qm74	8918	34	with	with	IN
cord-015021-pol2qm74	8918	35	an	an	DT
cord-015021-pol2qm74	8918	36	anfi	anfi	NNP
cord-015021-pol2qm74	8918	37	-	-	HYPH
cord-015021-pol2qm74	8918	38	bFGF	bfgf	NN
cord-015021-pol2qm74	8918	39	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8918	40	antibody	antibody	NN
cord-015021-pol2qm74	8918	41	.	.	.
cord-015021-pol2qm74	8919	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8919	2	study	study	NN
cord-015021-pol2qm74	8919	3	revealed	reveal	VBD
cord-015021-pol2qm74	8919	4	typical	typical	JJ
cord-015021-pol2qm74	8919	5	patterns	pattern	NNS
cord-015021-pol2qm74	8919	6	of	of	IN
cord-015021-pol2qm74	8919	7	bFGF	bfgf	JJ
cord-015021-pol2qm74	8919	8	-	-	HYPH
cord-015021-pol2qm74	8919	9	m	m	NNP
cord-015021-pol2qm74	8919	10	-	-	HYPH
cord-015021-pol2qm74	8919	11	RNA	rna	NN
cord-015021-pol2qm74	8919	12	-	-	HYPH
cord-015021-pol2qm74	8919	13	expression	expression	NN
cord-015021-pol2qm74	8919	14	and	and	CC
cord-015021-pol2qm74	8919	15	intense	intense	JJ
cord-015021-pol2qm74	8919	16	bFGFprotein	bFGFprotein	NNP
cord-015021-pol2qm74	8919	17	deposition	deposition	NN
cord-015021-pol2qm74	8919	18	during	during	IN
cord-015021-pol2qm74	8919	19	granulation	granulation	NN
cord-015021-pol2qm74	8919	20	tissue	tissue	NN
cord-015021-pol2qm74	8919	21	formation	formation	NN
cord-015021-pol2qm74	8919	22	and	and	CC
cord-015021-pol2qm74	8919	23	reepithelialJzation	reepithelialjzation	NN
cord-015021-pol2qm74	8919	24	of	of	IN
cord-015021-pol2qm74	8919	25	healing	heal	VBG
cord-015021-pol2qm74	8919	26	bum	bum	NN
cord-015021-pol2qm74	8919	27	wounds	wound	NNS
cord-015021-pol2qm74	8919	28	.	.	.
cord-015021-pol2qm74	8919	29	'	'	''
cord-015021-pol2qm74	8920	1	it	-PRON-	PRP
cord-015021-pol2qm74	8920	2	,	,	,
cord-015021-pol2qm74	8920	3	is	be	VBZ
cord-015021-pol2qm74	8920	4	known	know	VBN
cord-015021-pol2qm74	8920	5	that	that	IN
cord-015021-pol2qm74	8920	6	major	major	JJ
cord-015021-pol2qm74	8920	7	thermal	thermal	JJ
cord-015021-pol2qm74	8920	8	injuries	injury	NNS
cord-015021-pol2qm74	8920	9	cause	cause	VBP
cord-015021-pol2qm74	8920	10	early	early	JJ
cord-015021-pol2qm74	8920	11	impairment	impairment	NN
cord-015021-pol2qm74	8920	12	of	of	IN
cord-015021-pol2qm74	8920	13	wound	wound	JJ
cord-015021-pol2qm74	8920	14	healing	healing	NN
cord-015021-pol2qm74	8920	15	followed	follow	VBN
cord-015021-pol2qm74	8920	16	by	by	IN
cord-015021-pol2qm74	8920	17	decreased	decrease	VBN
cord-015021-pol2qm74	8920	18	influx	influx	NN
cord-015021-pol2qm74	8920	19	of	of	IN
cord-015021-pol2qm74	8920	20	granuiocytes	granuiocyte	NNS
cord-015021-pol2qm74	8920	21	St.	St.	NNP
cord-015021-pol2qm74	8920	22	the	the	DT
cord-015021-pol2qm74	8920	23	site	site	NN
cord-015021-pol2qm74	8920	24	of	of	IN
cord-015021-pol2qm74	8920	25	injury	injury	NN
cord-015021-pol2qm74	8920	26	.	.	.
cord-015021-pol2qm74	8921	1	The	the	DT
cord-015021-pol2qm74	8921	2	role	role	NN
cord-015021-pol2qm74	8921	3	of	of	IN
cord-015021-pol2qm74	8921	4	granuiocytes	granuiocyte	NNS
cord-015021-pol2qm74	8921	5	in	in	IN
cord-015021-pol2qm74	8921	6	the	the	DT
cord-015021-pol2qm74	8921	7	process	process	NN
cord-015021-pol2qm74	8921	8	of	of	IN
cord-015021-pol2qm74	8921	9	wound	wound	JJ
cord-015021-pol2qm74	8921	10	healing	healing	NN
cord-015021-pol2qm74	8921	11	is	be	VBZ
cord-015021-pol2qm74	8921	12	not	not	RB
cord-015021-pol2qm74	8921	13	~"~	~"~	NNP
cord-015021-pol2qm74	8921	14	"	"	''
cord-015021-pol2qm74	8921	15	"	"	``
cord-015021-pol2qm74	8921	16	elucidated	elucidate	VBN
cord-015021-pol2qm74	8921	17	,	,	,
cord-015021-pol2qm74	8921	18	it	-PRON-	PRP
cord-015021-pol2qm74	8921	19	is	be	VBZ
cord-015021-pol2qm74	8921	20	now	now	RB
cord-015021-pol2qm74	8921	21	assumed	assume	VBN
cord-015021-pol2qm74	8921	22	that	that	IN
cord-015021-pol2qm74	8921	23	they	-PRON-	PRP
cord-015021-pol2qm74	8921	24	are	be	VBP
cord-015021-pol2qm74	8921	25	not	not	RB
cord-015021-pol2qm74	8921	26	merely	merely	RB
cord-015021-pol2qm74	8921	27	phagocytic	phagocytic	JJ
cord-015021-pol2qm74	8921	28	cells	cell	NNS
cord-015021-pol2qm74	8921	29	but	but	CC
cord-015021-pol2qm74	8921	30	active	active	JJ
cord-015021-pol2qm74	8921	31	participants	participant	NNS
cord-015021-pol2qm74	8921	32	in	in	IN
cord-015021-pol2qm74	8921	33	~n~*'1~.	~n~*'1~.	NNP
cord-015021-pol2qm74	8921	34	,	,	,
cord-015021-pol2qm74	8921	35	.	.	.
cord-015021-pol2qm74	8922	1	,	,	,
cord-015021-pol2qm74	8922	2	a+~o~	a+~o~	NNP
cord-015021-pol2qm74	8922	3	:	:	:
cord-015021-pol2qm74	8922	4	processes	process	NNS
cord-015021-pol2qm74	8922	5	secreting	secrete	VBG
cord-015021-pol2qm74	8922	6	_	_	NN
cord-015021-pol2qm74	8922	7	a	a	DT
cord-015021-pol2qm74	8922	8	number	number	NN
cord-015021-pol2qm74	8922	9	of	of	IN
cord-015021-pol2qm74	8922	10	various	various	JJ
cord-015021-pol2qm74	8922	11	cvt-;kines	cvt-;kine	NNS
cord-015021-pol2qm74	8922	12	,	,	,
cord-015021-pol2qm74	8922	13	in	in	IN
cord-015021-pol2qm74	8922	14	order	order	NN
cord-015021-pol2qm74	8922	15	to	to	TO
cord-015021-pol2qm74	8922	16	investigate	investigate	VB
cord-015021-pol2qm74	8922	17	the	the	DT
cord-015021-pol2qm74	8922	18	effect	effect	NN
cord-015021-pol2qm74	8922	19	of	of	IN
cord-015021-pol2qm74	8922	20	There	there	EX
cord-015021-pol2qm74	8922	21	is	be	VBZ
cord-015021-pol2qm74	8922	22	accumulating	accumulate	VBG
cord-015021-pol2qm74	8922	23	evidence	evidence	NN
cord-015021-pol2qm74	8922	24	that	that	IN
cord-015021-pol2qm74	8922	25	neuropeptides	neuropeptide	NNS
cord-015021-pol2qm74	8922	26	could	could	MD
cord-015021-pol2qm74	8922	27	be	be	VB
cord-015021-pol2qm74	8922	28	involved	involve	VBN
cord-015021-pol2qm74	8922	29	in	in	IN
cord-015021-pol2qm74	8922	30	the	the	DT
cord-015021-pol2qm74	8922	31	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8922	32	of	of	IN
cord-015021-pol2qm74	8922	33	several	several	JJ
cord-015021-pol2qm74	8922	34	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8922	35	reactions	reaction	NNS
cord-015021-pol2qm74	8922	36	.	.	.
cord-015021-pol2qm74	8923	1	Vasocactive	Vasocactive	NNP
cord-015021-pol2qm74	8923	2	Intestinal	intestinal	JJ
cord-015021-pol2qm74	8923	3	Polypeptide	Polypeptide	NNP
cord-015021-pol2qm74	8923	4	(	(	-LRB-
cord-015021-pol2qm74	8923	5	VIP	VIP	NNP
cord-015021-pol2qm74	8923	6	)	)	-RRB-
cord-015021-pol2qm74	8923	7	and	and	CC
cord-015021-pol2qm74	8923	8	Substance	Substance	NNP
cord-015021-pol2qm74	8923	9	P	p	NN
cord-015021-pol2qm74	8923	10	(	(	-LRB-
cord-015021-pol2qm74	8923	11	SP	SP	NNP
cord-015021-pol2qm74	8923	12	)	)	-RRB-
cord-015021-pol2qm74	8923	13	have	have	VBP
cord-015021-pol2qm74	8923	14	been	be	VBN
cord-015021-pol2qm74	8923	15	detected	detect	VBN
cord-015021-pol2qm74	8923	16	by	by	IN
cord-015021-pol2qm74	8923	17	immunohistochemistry	immunohistochemistry	NN
cord-015021-pol2qm74	8923	18	in	in	IN
cord-015021-pol2qm74	8923	19	normal	normal	JJ
cord-015021-pol2qm74	8923	20	as	as	RB
cord-015021-pol2qm74	8923	21	well	well	RB
cord-015021-pol2qm74	8923	22	as	as	IN
cord-015021-pol2qm74	8923	23	inflammed	inflammed	JJ
cord-015021-pol2qm74	8923	24	skin	skin	NN
cord-015021-pol2qm74	8923	25	mostly	mostly	RB
cord-015021-pol2qm74	8923	26	in	in	IN
cord-015021-pol2qm74	8923	27	perivascular	perivascular	NNP
cord-015021-pol2qm74	8923	28	and	and	CC
cord-015021-pol2qm74	8923	29	periglandular	periglandular	JJ
cord-015021-pol2qm74	8923	30	location	location	NN
cord-015021-pol2qm74	8923	31	.	.	.
cord-015021-pol2qm74	8924	1	Both	both	DT
cord-015021-pol2qm74	8924	2	VIP	VIP	NNP
cord-015021-pol2qm74	8924	3	and	and	CC
cord-015021-pol2qm74	8924	4	SP	SP	NNP
cord-015021-pol2qm74	8924	5	are	be	VBP
cord-015021-pol2qm74	8924	6	involved	involve	VBN
cord-015021-pol2qm74	8924	7	in	in	IN
cord-015021-pol2qm74	8924	8	vasodilatation	vasodilatation	NN
cord-015021-pol2qm74	8924	9	,	,	,
cord-015021-pol2qm74	8924	10	mast	mast	JJ
cord-015021-pol2qm74	8924	11	cell	cell	NN
cord-015021-pol2qm74	8924	12	degranulation	degranulation	NN
cord-015021-pol2qm74	8924	13	and	and	CC
cord-015021-pol2qm74	8924	14	irnmunomodulation	irnmunomodulation	NN
cord-015021-pol2qm74	8924	15	.	.	.
cord-015021-pol2qm74	8925	1	We	-PRON-	PRP
cord-015021-pol2qm74	8925	2	determined	determine	VBD
cord-015021-pol2qm74	8925	3	the	the	DT
cord-015021-pol2qm74	8925	4	influence	influence	NN
cord-015021-pol2qm74	8925	5	of	of	IN
cord-015021-pol2qm74	8925	6	SP	SP	NNP
cord-015021-pol2qm74	8925	7	and	and	CC
cord-015021-pol2qm74	8925	8	VIP	vip	NN
cord-015021-pol2qm74	8925	9	on	on	IN
cord-015021-pol2qm74	8925	10	the	the	DT
cord-015021-pol2qm74	8925	11	proliferation	proliferation	NN
cord-015021-pol2qm74	8925	12	of	of	IN
cord-015021-pol2qm74	8925	13	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8925	14	in	in	IN
cord-015021-pol2qm74	8925	15	patients	patient	NNS
cord-015021-pol2qm74	8925	16	with	with	IN
cord-015021-pol2qm74	8925	17	psoriasis	psoriasis	NN
cord-015021-pol2qm74	8925	18	and	and	CC
cord-015021-pol2qm74	8925	19	healthy	healthy	JJ
cord-015021-pol2qm74	8925	20	individuals	individual	NNS
cord-015021-pol2qm74	8925	21	.	.	.
cord-015021-pol2qm74	8926	1	Peripheral	peripheral	JJ
cord-015021-pol2qm74	8926	2	blood	blood	NN
cord-015021-pol2qm74	8926	3	T	t	NN
cord-015021-pol2qm74	8926	4	-	-	HYPH
cord-015021-pol2qm74	8926	5	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8926	6	of	of	IN
cord-015021-pol2qm74	8926	7	6	6	CD
cord-015021-pol2qm74	8926	8	psoriatics	psoriatic	NNS
cord-015021-pol2qm74	8926	9	and	and	CC
cord-015021-pol2qm74	8926	10	6	6	CD
cord-015021-pol2qm74	8926	11	healthy	healthy	JJ
cord-015021-pol2qm74	8926	12	controls	control	NNS
cord-015021-pol2qm74	8926	13	were	be	VBD
cord-015021-pol2qm74	8926	14	isolated	isolate	VBN
cord-015021-pol2qm74	8926	15	by	by	IN
cord-015021-pol2qm74	8926	16	density	density	NN
cord-015021-pol2qm74	8926	17	gradient	gradient	NN
cord-015021-pol2qm74	8926	18	centrifugation	centrifugation	NN
cord-015021-pol2qm74	8926	19	and	and	CC
cord-015021-pol2qm74	8926	20	passage	passage	NN
cord-015021-pol2qm74	8926	21	over	over	IN
cord-015021-pol2qm74	8926	22	nylon	nylon	NN
cord-015021-pol2qm74	8926	23	wool	wool	NN
cord-015021-pol2qm74	8926	24	.	.	.
cord-015021-pol2qm74	8927	1	Cell	cell	NN
cord-015021-pol2qm74	8927	2	enrichment	enrichment	NN
cord-015021-pol2qm74	8927	3	was	be	VBD
cord-015021-pol2qm74	8927	4	controlled	control	VBN
cord-015021-pol2qm74	8927	5	by	by	IN
cord-015021-pol2qm74	8927	6	FACS	FACS	NNP
cord-015021-pol2qm74	8927	7	analysis	analysis	NN
cord-015021-pol2qm74	8927	8	,	,	,
cord-015021-pol2qm74	8927	9	lx105	lx105	NNP
cord-015021-pol2qm74	8927	10	T	T	NNP
cord-015021-pol2qm74	8927	11	-	-	HYPH
cord-015021-pol2qm74	8927	12	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8927	13	were	be	VBD
cord-015021-pol2qm74	8927	14	then	then	RB
cord-015021-pol2qm74	8927	15	incubated	incubate	VBN
cord-015021-pol2qm74	8927	16	alone	alone	RB
cord-015021-pol2qm74	8927	17	or	or	CC
cord-015021-pol2qm74	8927	18	in	in	IN
cord-015021-pol2qm74	8927	19	coculture	coculture	NN
cord-015021-pol2qm74	8927	20	with	with	IN
cord-015021-pol2qm74	8927	21	2x104	2x104	CD
cord-015021-pol2qm74	8927	22	irradiated	irradiate	VBN
cord-015021-pol2qm74	8927	23	autologous	autologous	JJ
cord-015021-pol2qm74	8927	24	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8927	25	in	in	IN
cord-015021-pol2qm74	8927	26	culture	culture	NN
cord-015021-pol2qm74	8927	27	medium	medium	NN
cord-015021-pol2qm74	8927	28	containing	contain	VBG
cord-015021-pol2qm74	8927	29	10	10	CD
cord-015021-pol2qm74	8927	30	-7	-7	NNP
cord-015021-pol2qm74	8927	31	mol	mol	NN
cord-015021-pol2qm74	8927	32	/	/	SYM
cord-015021-pol2qm74	8927	33	I	I	NNP
cord-015021-pol2qm74	8927	34	SP	SP	NNP
cord-015021-pol2qm74	8927	35	or	or	CC
cord-015021-pol2qm74	8927	36	VIP	VIP	NNP
cord-015021-pol2qm74	8927	37	.	.	.
cord-015021-pol2qm74	8928	1	Cell	cell	NN
cord-015021-pol2qm74	8928	2	proliferation	proliferation	NN
cord-015021-pol2qm74	8928	3	was	be	VBD
cord-015021-pol2qm74	8928	4	measured	measure	VBN
cord-015021-pol2qm74	8928	5	semiquanfitatively	semiquanfitatively	RB
cord-015021-pol2qm74	8928	6	by	by	IN
cord-015021-pol2qm74	8928	7	TdR	tdr	NN
cord-015021-pol2qm74	8928	8	uptake	uptake	NN
cord-015021-pol2qm74	8928	9	in	in	IN
cord-015021-pol2qm74	8928	10	a	a	DT
cord-015021-pol2qm74	8928	11	betacounter	betacounter	NN
cord-015021-pol2qm74	8928	12	.	.	.
cord-015021-pol2qm74	8929	1	Significance	significance	NN
cord-015021-pol2qm74	8929	2	was	be	VBD
cord-015021-pol2qm74	8929	3	tested	test	VBN
cord-015021-pol2qm74	8929	4	by	by	IN
cord-015021-pol2qm74	8929	5	the	the	DT
cord-015021-pol2qm74	8929	6	Wilcoxon	Wilcoxon	NNP
cord-015021-pol2qm74	8929	7	signed	sign	VBN
cord-015021-pol2qm74	8929	8	-	-	HYPH
cord-015021-pol2qm74	8929	9	rank	rank	NN
cord-015021-pol2qm74	8929	10	test	test	NN
cord-015021-pol2qm74	8929	11	.	.	.
cord-015021-pol2qm74	8930	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8930	2	results	result	NNS
cord-015021-pol2qm74	8930	3	show	show	VBP
cord-015021-pol2qm74	8930	4	that	that	IN
cord-015021-pol2qm74	8930	5	SP	SP	NNP
cord-015021-pol2qm74	8930	6	and	and	CC
cord-015021-pol2qm74	8930	7	VIP	VIP	NNP
cord-015021-pol2qm74	8930	8	exert	exert	VBP
cord-015021-pol2qm74	8930	9	only	only	RB
cord-015021-pol2qm74	8930	10	an	an	DT
cord-015021-pol2qm74	8930	11	effect	effect	NN
cord-015021-pol2qm74	8930	12	on	on	IN
cord-015021-pol2qm74	8930	13	unstirnulated	unstirnulated	JJ
cord-015021-pol2qm74	8930	14	T	T	NNP
cord-015021-pol2qm74	8930	15	-	-	HYPH
cord-015021-pol2qm74	8930	16	cells	cell	NNS
cord-015021-pol2qm74	8930	17	.	.	.
cord-015021-pol2qm74	8931	1	In	in	IN
cord-015021-pol2qm74	8931	2	healthy	healthy	JJ
cord-015021-pol2qm74	8931	3	individuals	individual	NNS
cord-015021-pol2qm74	8931	4	but	but	CC
cord-015021-pol2qm74	8931	5	not	not	RB
cord-015021-pol2qm74	8931	6	in	in	IN
cord-015021-pol2qm74	8931	7	patients	patient	NNS
cord-015021-pol2qm74	8931	8	with	with	IN
cord-015021-pol2qm74	8931	9	psoriasis	psoriasis	NN
cord-015021-pol2qm74	8931	10	SP	SP	NNP
cord-015021-pol2qm74	8931	11	increases	increase	VBZ
cord-015021-pol2qm74	8931	12	significantly	significantly	RB
cord-015021-pol2qm74	8931	13	proliferation	proliferation	NN
cord-015021-pol2qm74	8931	14	of	of	IN
cord-015021-pol2qm74	8931	15	T	t	NN
cord-015021-pol2qm74	8931	16	-	-	HYPH
cord-015021-pol2qm74	8931	17	cells	cell	NNS
cord-015021-pol2qm74	8931	18	.	.	.
cord-015021-pol2qm74	8932	1	VIP	VIP	NNP
cord-015021-pol2qm74	8932	2	,	,	,
cord-015021-pol2qm74	8932	3	however	however	RB
cord-015021-pol2qm74	8932	4	stimulates	stimulate	VBZ
cord-015021-pol2qm74	8932	5	significantly	significantly	RB
cord-015021-pol2qm74	8932	6	the	the	DT
cord-015021-pol2qm74	8932	7	blastogenesis	blastogenesis	NN
cord-015021-pol2qm74	8932	8	of	of	IN
cord-015021-pol2qm74	8932	9	T	T	NNP
cord-015021-pol2qm74	8932	10	-	-	HYPH
cord-015021-pol2qm74	8932	11	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8932	12	only	only	RB
cord-015021-pol2qm74	8932	13	in	in	IN
cord-015021-pol2qm74	8932	14	psoriatics	psoriatic	NNS
cord-015021-pol2qm74	8932	15	.	.	.
cord-015021-pol2qm74	8933	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8933	2	results	result	NNS
cord-015021-pol2qm74	8933	3	confirm	confirm	VBP
cord-015021-pol2qm74	8933	4	the	the	DT
cord-015021-pol2qm74	8933	5	psychoneuroimmunologic	psychoneuroimmunologic	JJ
cord-015021-pol2qm74	8933	6	component	component	NN
cord-015021-pol2qm74	8933	7	in	in	IN
cord-015021-pol2qm74	8933	8	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	8933	9	reactions	reaction	NNS
cord-015021-pol2qm74	8933	10	and	and	CC
cord-015021-pol2qm74	8933	11	VIP	vip	NN
cord-015021-pol2qm74	8933	12	and	and	CC
cord-015021-pol2qm74	8933	13	SP	SP	NNP
cord-015021-pol2qm74	8933	14	could	could	MD
cord-015021-pol2qm74	8933	15	be	be	VB
cord-015021-pol2qm74	8933	16	partially	partially	RB
cord-015021-pol2qm74	8933	17	implicated	implicate	VBN
cord-015021-pol2qm74	8933	18	in	in	IN
cord-015021-pol2qm74	8933	19	their	-PRON-	PRP$
cord-015021-pol2qm74	8933	20	pathogenetic	pathogenetic	JJ
cord-015021-pol2qm74	8933	21	mechanisms	mechanism	NNS
cord-015021-pol2qm74	8933	22	.	.	.
cord-015021-pol2qm74	8934	1	Moreover	moreover	RB
cord-015021-pol2qm74	8934	2	psoriatic	psoriatic	JJ
cord-015021-pol2qm74	8934	3	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8934	4	show	show	VBP
cord-015021-pol2qm74	8934	5	an	an	DT
cord-015021-pol2qm74	8934	6	altered	altered	JJ
cord-015021-pol2qm74	8934	7	reaction	reaction	NN
cord-015021-pol2qm74	8934	8	to	to	IN
cord-015021-pol2qm74	8934	9	SP	SP	NNP
cord-015021-pol2qm74	8934	10	and	and	CC
cord-015021-pol2qm74	8934	11	VIP	VIP	NNP
cord-015021-pol2qm74	8934	12	.	.	.
cord-015021-pol2qm74	8935	1	This	this	DT
cord-015021-pol2qm74	8935	2	might	may	MD
cord-015021-pol2qm74	8935	3	be	be	VB
cord-015021-pol2qm74	8935	4	due	due	JJ
cord-015021-pol2qm74	8935	5	to	to	IN
cord-015021-pol2qm74	8935	6	a	a	DT
cord-015021-pol2qm74	8935	7	preexisting	preexisting	JJ
cord-015021-pol2qm74	8935	8	(	(	-LRB-
cord-015021-pol2qm74	8935	9	genetic	genetic	JJ
cord-015021-pol2qm74	8935	10	?	?	.
cord-015021-pol2qm74	8935	11	)	)	-RRB-
cord-015021-pol2qm74	8935	12	or	or	CC
cord-015021-pol2qm74	8935	13	more	more	RBR
cord-015021-pol2qm74	8935	14	likely	likely	JJ
cord-015021-pol2qm74	8935	15	to	to	IN
cord-015021-pol2qm74	8935	16	an	an	DT
cord-015021-pol2qm74	8935	17	epiphenomenal	epiphenomenal	JJ
cord-015021-pol2qm74	8935	18	receptor	receptor	NN
cord-015021-pol2qm74	8935	19	defect	defect	NN
cord-015021-pol2qm74	8935	20	.	.	.
cord-015021-pol2qm74	8936	1	The	the	DT
cord-015021-pol2qm74	8936	2	adhesive	adhesive	JJ
cord-015021-pol2qm74	8936	3	interactions	interaction	NNS
cord-015021-pol2qm74	8936	4	between	between	IN
cord-015021-pol2qm74	8936	5	endothelial	endothelial	JJ
cord-015021-pol2qm74	8936	6	cells	cell	NNS
cord-015021-pol2qm74	8936	7	and	and	CC
cord-015021-pol2qm74	8936	8	circulating	circulate	VBG
cord-015021-pol2qm74	8936	9	~enkocytes	~enkocytes	XX
cord-015021-pol2qm74	8936	10	in	in	IN
cord-015021-pol2qm74	8936	11	shock	shock	NN
cord-015021-pol2qm74	8936	12	and	and	CC
cord-015021-pol2qm74	8936	13	innammatory	innammatory	JJ
cord-015021-pol2qm74	8936	14	vondltions	vondltion	NNS
cord-015021-pol2qm74	8936	15	is	be	VBZ
cord-015021-pol2qm74	8936	16	mediated	mediate	VBN
cord-015021-pol2qm74	8936	17	by	by	IN
cord-015021-pol2qm74	8936	18	several	several	JJ
cord-015021-pol2qm74	8936	19	distinct	distinct	JJ
cord-015021-pol2qm74	8936	20	families	family	NNS
cord-015021-pol2qm74	8936	21	of	of	IN
cord-015021-pol2qm74	8936	22	ce11-surface	ce11-surface	NN
cord-015021-pol2qm74	8936	23	determinants	determinant	NNS
cord-015021-pol2qm74	8936	24	.	.	.
cord-015021-pol2qm74	8937	1	Of	of	IN
cord-015021-pol2qm74	8937	2	particular	particular	JJ
cord-015021-pol2qm74	8937	3	importance	importance	NN
cord-015021-pol2qm74	8937	4	are	be	VBP
cord-015021-pol2qm74	8937	5	the	the	DT
cord-015021-pol2qm74	8937	6	leukocyte	leukocyte	NN
cord-015021-pol2qm74	8937	7	integrins	integrin	NNS
cord-015021-pol2qm74	8937	8	CDIB	CDIB	NNP
cord-015021-pol2qm74	8937	9	/	/	SYM
cord-015021-pol2qm74	8937	10	CDlla	CDlla	NNP
cord-015021-pol2qm74	8937	11	-	-	HYPH
cord-015021-pol2qm74	8937	12	c	c	NNP
cord-015021-pol2qm74	8937	13	.	.	.
cord-015021-pol2qm74	8938	1	In	in	IN
cord-015021-pol2qm74	8938	2	this	this	DT
cord-015021-pol2qm74	8938	3	study	study	NN
cord-015021-pol2qm74	8938	4	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8938	5	antibodies	antibody	NNS
cord-015021-pol2qm74	8938	6	to	to	IN
cord-015021-pol2qm74	8938	7	two	two	CD
cord-015021-pol2qm74	8938	8	of	of	IN
cord-015021-pol2qm74	8938	9	the	the	DT
cord-015021-pol2qm74	8938	10	u	u	NNP
cord-015021-pol2qm74	8938	11	chains	chain	NNS
cord-015021-pol2qm74	8938	12	(	(	-LRB-
cord-015021-pol2qm74	8938	13	CDlla	CDlla	NNP
cord-015021-pol2qm74	8938	14	&	&	CC
cord-015021-pol2qm74	8938	15	CDIIb	CDIIb	NNP
cord-015021-pol2qm74	8938	16	)	)	-RRB-
cord-015021-pol2qm74	8938	17	and	and	CC
cord-015021-pol2qm74	8938	18	the	the	DT
cord-015021-pol2qm74	8938	19	common	common	JJ
cord-015021-pol2qm74	8938	20	[	[	-LRB-
cord-015021-pol2qm74	8938	21	~	~	CD
cord-015021-pol2qm74	8938	22	chain	chain	NN
cord-015021-pol2qm74	8938	23	(	(	-LRB-
cord-015021-pol2qm74	8938	24	CDIB	CDIB	NNP
cord-015021-pol2qm74	8938	25	)	)	-RRB-
cord-015021-pol2qm74	8938	26	have	have	VBP
cord-015021-pol2qm74	8938	27	been	be	VBN
cord-015021-pol2qm74	8938	28	used	use	VBN
cord-015021-pol2qm74	8938	29	to	to	TO
cord-015021-pol2qm74	8938	30	investigate	investigate	VB
cord-015021-pol2qm74	8938	31	leukocyte	leukocyte	NN
cord-015021-pol2qm74	8938	32	-	-	HYPH
cord-015021-pol2qm74	8938	33	dependent	dependent	JJ
cord-015021-pol2qm74	8938	34	and	and	CC
cord-015021-pol2qm74	8938	35	leukocyte	leukocyte	NN
cord-015021-pol2qm74	8938	36	-	-	HYPH
cord-015021-pol2qm74	8938	37	independent	independent	JJ
cord-015021-pol2qm74	8938	38	plasma	plasma	NN
cord-015021-pol2qm74	8938	39	leakage	leakage	NN
cord-015021-pol2qm74	8938	40	in	in	IN
cord-015021-pol2qm74	8938	41	tee	tee	NN
cord-015021-pol2qm74	8938	42	skin	skin	NN
cord-015021-pol2qm74	8938	43	of	of	IN
cord-015021-pol2qm74	8938	44	rabbite	rabbite	NNP
cord-015021-pol2qm74	8938	45	.	.	.
cord-015021-pol2qm74	8939	1	Plasma	plasma	NN
cord-015021-pol2qm74	8939	2	leakage	leakage	NN
cord-015021-pol2qm74	8939	3	was	be	VBD
cord-015021-pol2qm74	8939	4	measured	measure	VBN
cord-015021-pol2qm74	8939	5	as	as	IN
cord-015021-pol2qm74	8939	6	the	the	DT
cord-015021-pol2qm74	8939	7	local	local	JJ
cord-015021-pol2qm74	8939	8	accumulation	accumulation	NN
cord-015021-pol2qm74	8939	9	of	of	IN
cord-015021-pol2qm74	8939	10	t2sI	t2sI	NNP
cord-015021-pol2qm74	8939	11	-	-	:
cord-015021-pol2qm74	8939	12	HSA	HSA	NNP
cord-015021-pol2qm74	8939	13	over	over	IN
cord-015021-pol2qm74	8939	14	a	a	DT
cord-015021-pol2qm74	8939	15	30	30	CD
cord-015021-pol2qm74	8939	16	rain	rain	NN
cord-015021-pol2qm74	8939	17	period	period	NN
cord-015021-pol2qm74	8939	18	,	,	,
cord-015021-pol2qm74	8939	19	The	the	DT
cord-015021-pol2qm74	8939	20	chemotac	chemotac	NNP
cord-015021-pol2qm74	8939	21	~	~	NFP
cord-015021-pol2qm74	8939	22	c	c	NNP
cord-015021-pol2qm74	8939	23	peptide	peptide	NN
cord-015021-pol2qm74	8939	24	IMLP	IMLP	NNP
cord-015021-pol2qm74	8939	25	(	(	-LRB-
cord-015021-pol2qm74	8939	26	0.1	0.1	CD
cord-015021-pol2qm74	8939	27	.	.	.
cord-015021-pol2qm74	8939	28	30ng	30ng	LS
cord-015021-pol2qm74	8939	29	)	)	-RRB-
cord-015021-pol2qm74	8939	30	and	and	CC
cord-015021-pol2qm74	8939	31	bradykinin	bradykinin	NN
cord-015021-pol2qm74	8939	32	were	be	VBD
cord-015021-pol2qm74	8939	33	used	use	VBN
cord-015021-pol2qm74	8939	34	to	to	TO
cord-015021-pol2qm74	8939	35	induce	induce	VB
cord-015021-pol2qm74	8939	36	cell.dependent	cell.dependent	NN
cord-015021-pol2qm74	8939	37	and	and	CC
cord-015021-pol2qm74	8939	38	cell-5ndependent	cell-5ndependent	NN
cord-015021-pol2qm74	8939	39	leakage	leakage	NN
cord-015021-pol2qm74	8939	40	respectively	respectively	RB
cord-015021-pol2qm74	8939	41	,	,	,
cord-015021-pol2qm74	8939	42	The	the	DT
cord-015021-pol2qm74	8939	43	antibodies	antibody	NNS
cord-015021-pol2qm74	8939	44	used	use	VBN
cord-015021-pol2qm74	8939	45	were	be	VBD
cord-015021-pol2qm74	8939	46	6.5E	6.5E	NNS
cord-015021-pol2qm74	8940	1	(	(	-LRB-
cord-015021-pol2qm74	8940	2	CDIS	CDIS	NNP
cord-015021-pol2qm74	8940	3	)	)	-RRB-
cord-015021-pol2qm74	8940	4	,	,	.
cord-015021-pol2qm74	8941	1	NRI85	NRI85	NNP
cord-015021-pol2qm74	8941	2	(	(	-LRB-
cord-015021-pol2qm74	8941	3	CDlla	CDlla	NNP
cord-015021-pol2qm74	8941	4	)	)	-RRB-
cord-015021-pol2qm74	8941	5	and	and	CC
cord-015021-pol2qm74	8941	6	antibody	antibody	NN
cord-015021-pol2qm74	8941	7	198	198	CD
cord-015021-pol2qm74	8941	8	(	(	-LRB-
cord-015021-pol2qm74	8941	9	CDllb	CDllb	NNP
cord-015021-pol2qm74	8941	10	)	)	-RRB-
cord-015021-pol2qm74	8941	11	.	.	.
cord-015021-pol2qm74	8941	12	]	]	-RRB-
cord-015021-pol2qm74	8942	1	ntradermal	ntradermal	NNP
cord-015021-pol2qm74	8942	2	in	in	IN
cord-015021-pol2qm74	8942	3	~	~	CD
cord-015021-pol2qm74	8942	4	ections	ection	NNS
cord-015021-pol2qm74	8942	5	of	of	IN
cord-015021-pol2qm74	8942	6	bradyklnin	bradyklnin	NNS
cord-015021-pol2qm74	8942	7	and	and	CC
cord-015021-pol2qm74	8942	8	~dLP	~dLP	NNP
cord-015021-pol2qm74	8943	1	both	both	DT
cord-015021-pol2qm74	8943	2	caused	cause	VBD
cord-015021-pol2qm74	8943	3	a	a	DT
cord-015021-pol2qm74	8943	4	dose	dose	NN
cord-015021-pol2qm74	8943	5	dependent	dependent	JJ
cord-015021-pol2qm74	8943	6	increase	increase	NN
cord-015021-pol2qm74	8943	7	in	in	IN
cord-015021-pol2qm74	8943	8	plasma	plasma	NN
cord-015021-pol2qm74	8943	9	extravasatien	extravasatien	NN
cord-015021-pol2qm74	8944	1	(	(	-LRB-
cord-015021-pol2qm74	8944	2	15.~.	15.~.	NNP
cord-015021-pol2qm74	8944	3	ffi	ffi	NNP
cord-015021-pol2qm74	8944	4	2.1p.l	2.1p.l	CD
cord-015021-pol2qm74	8944	5	to	to	IN
cord-015021-pol2qm74	8944	6	54.4	54.4	CD
cord-015021-pol2qm74	8944	7	z	z	NNP
cord-015021-pol2qm74	8944	8	B.Bttl	B.Bttl	NNP
cord-015021-pol2qm74	8944	9	and	and	CC
cord-015021-pol2qm74	8944	10	16.4	16.4	CD
cord-015021-pol2qm74	8944	11	,	,	,
cord-015021-pol2qm74	8944	12	-1.8~	-1.8~	VBG
cord-015021-pol2qm74	8944	13	to	to	IN
cord-015021-pol2qm74	8944	14	59.8	59.8	CD
cord-015021-pol2qm74	8944	15	z	z	NNP
cord-015021-pol2qm74	8944	16	6.71d	6.71d	CD
cord-015021-pol2qm74	8944	17	respectively	respectively	RB
cord-015021-pol2qm74	8944	18	.	.	.
cord-015021-pol2qm74	8945	1	6.5E	6.5E	NNS
cord-015021-pol2qm74	8946	1	(	(	-LRB-
cord-015021-pol2qm74	8946	2	0.0072	0.0072	CD
cord-015021-pol2qm74	8946	3	-	-	HYPH
cord-015021-pol2qm74	8946	4	2.4mF,/k~	2.4mf,/k~	JJ
cord-015021-pol2qm74	8946	5	iv	iv	CD
cord-015021-pol2qm74	8946	6	)	)	-RRB-
cord-015021-pol2qm74	8946	7	caused	cause	VBD
cord-015021-pol2qm74	8946	8	a	a	DT
cord-015021-pol2qm74	8946	9	dose	dose	JJ
cord-015021-pol2qm74	8946	10	dependent	dependent	JJ
cord-015021-pol2qm74	8946	11	inhibition	inhibition	NN
cord-015021-pol2qm74	8946	12	of	of	IN
cord-015021-pol2qm74	8946	13	IMLP	IMLP	NNP
cord-015021-pol2qm74	8946	14	-	-	HYPH
cord-015021-pol2qm74	8946	15	induced	induce	VBN
cord-015021-pol2qm74	8946	16	but	but	CC
cord-015021-pol2qm74	8946	17	not	not	RB
cord-015021-pol2qm74	8946	18	bradyldnin.inducecl	bradyldnin.inducecl	JJ
cord-015021-pol2qm74	8946	19	plasma	plasma	NN
cord-015021-pol2qm74	8946	20	exudation	exudation	NN
cord-015021-pol2qm74	8946	21	.	.	.
cord-015021-pol2qm74	8947	1	At	at	IN
cord-015021-pol2qm74	8947	2	0.24mk	0.24mk	CD
cord-015021-pol2qm74	8947	3	/	/	SYM
cord-015021-pol2qm74	8947	4	kg	kg	NNS
cord-015021-pol2qm74	8947	5	,	,	,
cord-015021-pol2qm74	8947	6	the	the	DT
cord-015021-pol2qm74	8947	7	plasma	plasma	NN
cord-015021-pol2qm74	8947	8	leakage	leakage	NN
cord-015021-pol2qm74	8947	9	was	be	VBD
cord-015021-pol2qm74	8947	10	completely	completely	RB
cord-015021-pol2qm74	8947	11	inhibited	inhibit	VBN
cord-015021-pol2qm74	8947	12	,	,	,
cord-015021-pol2qm74	8947	13	Antibody	Antibody	NNP
cord-015021-pol2qm74	8947	14	NR185	nr185	CD
cord-015021-pol2qm74	8947	15	produced	produce	VBD
cord-015021-pol2qm74	8947	16	similar	similar	JJ
cord-015021-pol2qm74	8947	17	results	result	NNS
cord-015021-pol2qm74	8947	18	,	,	,
cord-015021-pol2qm74	8947	19	Treatment	treatment	NN
cord-015021-pol2qm74	8947	20	with	with	IN
cord-015021-pol2qm74	8947	21	antibody	antibody	NN
cord-015021-pol2qm74	8947	22	198	198	CD
cord-015021-pol2qm74	8947	23	did	do	VBD
cord-015021-pol2qm74	8947	24	not	not	RB
cord-015021-pol2qm74	8947	25	cause	cause	VB
cord-015021-pol2qm74	8947	26	inhibition	inhibition	NN
cord-015021-pol2qm74	8947	27	o£	o£	NN
cord-015021-pol2qm74	8947	28	plasma	plasma	NN
cord-015021-pol2qm74	8947	29	leakage	leakage	NN
cord-015021-pol2qm74	8947	30	due	due	IN
cord-015021-pol2qm74	8947	31	to	to	IN
cord-015021-pol2qm74	8947	32	either	either	CC
cord-015021-pol2qm74	8947	33	Tnedi	Tnedi	NNP
cord-015021-pol2qm74	8947	34	~	~	NFP
cord-015021-pol2qm74	8947	35	tor	tor	XX
cord-015021-pol2qm74	8947	36	.	.	.
cord-015021-pol2qm74	8948	1	In	in	IN
cord-015021-pol2qm74	8948	2	vitro	vitro	FW
cord-015021-pol2qm74	8948	3	,	,	,
cord-015021-pol2qm74	8948	4	The	the	DT
cord-015021-pol2qm74	8948	5	irmnune	irmnune	NNP
cord-015021-pol2qm74	8948	6	system	system	NN
cord-015021-pol2qm74	8948	7	ex	ex	NN
cord-015021-pol2qm74	8948	8	~	~	CD
cord-015021-pol2qm74	8948	9	nination	nination	NN
cord-015021-pol2qm74	8948	10	in	in	IN
cord-015021-pol2qm74	8948	11	persons	person	NNS
cord-015021-pol2qm74	8948	12	with	with	IN
cord-015021-pol2qm74	8948	13	bone	bone	NN
cord-015021-pol2qm74	8948	14	,	,	,
cord-015021-pol2qm74	8948	15	chest	chest	NN
cord-015021-pol2qm74	8948	16	and	and	CC
cord-015021-pol2qm74	8948	17	abdominal	abdominal	JJ
cord-015021-pol2qm74	8948	18	traumatic	traumatic	JJ
cord-015021-pol2qm74	8948	19	injury	injury	NN
cord-015021-pol2qm74	8948	20	(	(	-LRB-
cord-015021-pol2qm74	8948	21	I	i	NN
cord-015021-pol2qm74	8948	22	group	group	NN
cord-015021-pol2qm74	8948	23	.	.	.
cord-015021-pol2qm74	8949	1	22	22	CD
cord-015021-pol2qm74	8949	2	patients	patient	NNS
cord-015021-pol2qm74	8949	3	without	without	IN
cord-015021-pol2qm74	8949	4	infectious	infectious	JJ
cord-015021-pol2qm74	8949	5	coz	coz	NNP
cord-015021-pol2qm74	8949	6	~	~	CD
cord-015021-pol2qm74	8949	7	lications	lication	NNS
cord-015021-pol2qm74	8949	8	and	and	CC
cord-015021-pol2qm74	8949	9	2	2	CD
cord-015021-pol2qm74	8949	10	group	group	NN
cord-015021-pol2qm74	8949	11	-53	-53	NNP
cord-015021-pol2qm74	8949	12	patients	patient	NNS
cord-015021-pol2qm74	8949	13	with	with	IN
cord-015021-pol2qm74	8949	14	wound	wound	JJ
cord-015021-pol2qm74	8949	15	infections	infection	NNS
cord-015021-pol2qm74	8949	16	development	development	NN
cord-015021-pol2qm74	8949	17	)	)	-RRB-
cord-015021-pol2qm74	8949	18	was	be	VBD
cord-015021-pol2qm74	8949	19	carried	carry	VBN
cord-015021-pol2qm74	8949	20	out	out	RP
cord-015021-pol2qm74	8949	21	.	.	.
cord-015021-pol2qm74	8950	1	To	to	TO
cord-015021-pol2qm74	8950	2	restore	restore	VB
cord-015021-pol2qm74	8950	3	found	find	VBN
cord-015021-pol2qm74	8950	4	immunity	immunity	NN
cord-015021-pol2qm74	8950	5	disorders	disorder	NNS
cord-015021-pol2qm74	8950	6	and	and	CC
cord-015021-pol2qm74	8950	7	host	host	NN
cord-015021-pol2qm74	8950	8	defense	defense	NN
cord-015021-pol2qm74	8950	9	to	to	IN
cord-015021-pol2qm74	8950	10	infection	infection	NN
cord-015021-pol2qm74	8950	11	23	23	CD
cord-015021-pol2qm74	8950	12	patients	patient	NNS
cord-015021-pol2qm74	8950	13	of	of	IN
cord-015021-pol2qm74	8950	14	the	the	DT
cord-015021-pol2qm74	8950	15	2	2	CD
cord-015021-pol2qm74	8950	16	group	group	NN
cord-015021-pol2qm74	8950	17	were	be	VBD
cord-015021-pol2qm74	8950	18	treated	treat	VBN
cord-015021-pol2qm74	8950	19	with	with	IN
cord-015021-pol2qm74	8950	20	Thymalin	Thymalin	NNP
cord-015021-pol2qm74	8950	21	-	-	,
cord-015021-pol2qm74	8950	22	the	the	DT
cord-015021-pol2qm74	8950	23	biologically	biologically	RB
cord-015021-pol2qm74	8950	24	active	active	JJ
cord-015021-pol2qm74	8950	25	peptides	peptide	NNS
cord-015021-pol2qm74	8950	26	prepared	prepare	VBN
cord-015021-pol2qm74	8950	27	from	from	IN
cord-015021-pol2qm74	8950	28	bovine	bovine	JJ
cord-015021-pol2qm74	8950	29	thymus	thymus	NN
cord-015021-pol2qm74	8950	30	.	.	.
cord-015021-pol2qm74	8951	1	The	the	DT
cord-015021-pol2qm74	8951	2	examination	examination	NN
cord-015021-pol2qm74	8951	3	on	on	IN
cord-015021-pol2qm74	8951	4	t	t	NN
cord-015021-pol2qm74	8951	5	~	~	NFP
cord-015021-pol2qm74	8951	6	e	e	NN
cord-015021-pol2qm74	8951	7	I-3	I-3	NNP
cord-015021-pol2qm74	8951	8	days	day	NNS
cord-015021-pol2qm74	8951	9	after	after	IN
cord-015021-pol2qm74	8951	10	injury	injury	NN
cord-015021-pol2qm74	8951	11	revealed	reveal	VBD
cord-015021-pol2qm74	8951	12	a	a	DT
cord-015021-pol2qm74	8951	13	considerable	considerable	JJ
cord-015021-pol2qm74	8951	14	decrease	decrease	NN
cord-015021-pol2qm74	8951	15	of	of	IN
cord-015021-pol2qm74	8951	16	lymphocytes	lymphocyte	NNS
cord-015021-pol2qm74	8951	17	,	,	,
cord-015021-pol2qm74	8951	18	eD3",$D4	eD3",$D4	NNP
cord-015021-pol2qm74	8951	19	~	~	NFP
cord-015021-pol2qm74	8951	20	and	and	CC
cord-015021-pol2qm74	8951	21	CD8	CD8	NNP
cord-015021-pol2qm74	8951	22	cells	cell	NNS
cord-015021-pol2qm74	8952	1	amo	amo	NNP
cord-015021-pol2qm74	8953	1	~it	~it	NNS
cord-015021-pol2qm74	8953	2	in	in	IN
cord-015021-pol2qm74	8953	3	the	the	DT
cord-015021-pol2qm74	8953	4	blood	blood	NN
cord-015021-pol2qm74	8953	5	,	,	,
cord-015021-pol2qm74	8953	6	CD4	CD4	NNP
cord-015021-pol2qm74	8953	7	/CD8	/CD8	:
cord-015021-pol2qm74	8953	8	ratio	ratio	NN
cord-015021-pol2qm74	8953	9	and	and	CC
cord-015021-pol2qm74	8953	10	indexes	index	NNS
cord-015021-pol2qm74	8953	11	of	of	IN
cord-015021-pol2qm74	8953	12	let	let	VB
cord-015021-pol2qm74	8953	13	~	~	CD
cord-015021-pol2qm74	8953	14	ocyte	ocyte	NNP
cord-015021-pol2qm74	8953	15	migration	migration	NN
cord-015021-pol2qm74	8953	16	inhibition	inhibition	NN
cord-015021-pol2qm74	8953	17	test	test	NN
cord-015021-pol2qm74	8953	18	in	in	IN
cord-015021-pol2qm74	8953	19	both	both	DT
cord-015021-pol2qm74	8953	20	groups	group	NNS
cord-015021-pol2qm74	8953	21	of	of	IN
cord-015021-pol2qm74	8953	22	patients	patient	NNS
cord-015021-pol2qm74	8953	23	.	.	.
cord-015021-pol2qm74	8954	1	The	the	DT
cord-015021-pol2qm74	8954	2	imm	imm	NNP
cord-015021-pol2qm74	8954	3	~	~	NFP
cord-015021-pol2qm74	8954	4	lity	lity	NN
cord-015021-pol2qm74	8954	5	disorders	disorder	NNS
cord-015021-pol2qm74	8954	6	recovered	recover	VBN
cord-015021-pol2qm74	8954	7	to	to	IN
cord-015021-pol2qm74	8954	8	norm	norm	NN
cord-015021-pol2qm74	8954	9	on	on	IN
cord-015021-pol2qm74	8954	10	the	the	DT
cord-015021-pol2qm74	8954	11	7	7	CD
cord-015021-pol2qm74	8954	12	-	-	SYM
cord-015021-pol2qm74	8954	13	10	10	CD
cord-015021-pol2qm74	8954	14	days	day	NNS
cord-015021-pol2qm74	8954	15	in	in	IN
cord-015021-pol2qm74	8954	16	pateents	pateent	NNS
cord-015021-pol2qm74	8954	17	of+the	of+the	DT
cord-015021-pol2qm74	8954	18	I	-PRON-	PRP
cord-015021-pol2qm74	8954	19	group	group	NN
cord-015021-pol2qm74	8954	20	.	.	.
cord-015021-pol2qm74	8955	1	But	but	CC
cord-015021-pol2qm74	8955	2	stable	stable	JJ
cord-015021-pol2qm74	8955	3	~eple$ion	~eple$ion	NN
cord-015021-pol2qm74	8955	4	of	of	IN
cord-015021-pol2qm74	8955	5	CD3	CD3	NNP
cord-015021-pol2qm74	8955	6	and	and	CC
cord-015021-pol2qm74	8955	7	CD4	CD4	NNP
cord-015021-pol2qm74	8955	8	cells	cell	NNS
cord-015021-pol2qm74	8955	9	amount	amount	NN
cord-015021-pol2qm74	8955	10	,	,	,
cord-015021-pol2qm74	8955	11	lower	low	JJR
cord-015021-pol2qm74	8955	12	CD4	CD4	NNP
cord-015021-pol2qm74	8955	13	/CD8	/CD8	,
cord-015021-pol2qm74	8955	14	ratio	ratio	NN
cord-015021-pol2qm74	8955	15	and	and	CC
cord-015021-pol2qm74	8955	16	indexes	index	NNS
cord-015021-pol2qm74	8955	17	of	of	IN
cord-015021-pol2qm74	8955	18	leukocyte	leukocyte	NN
cord-015021-pol2qm74	8955	19	migration	migration	NN
cord-015021-pol2qm74	8955	20	inhibition	inhibition	NN
cord-015021-pol2qm74	8955	21	test	test	NN
cord-015021-pol2qm74	8955	22	in	in	IN
cord-015021-pol2qm74	8955	23	patients	patient	NNS
cord-015021-pol2qm74	8955	24	of	of	IN
cord-015021-pol2qm74	8955	25	the	the	DT
cord-015021-pol2qm74	8955	26	2	2	CD
cord-015021-pol2qm74	8955	27	group	group	NN
cord-015021-pol2qm74	8955	28	were	be	VBD
cord-015021-pol2qm74	8955	29	observed~	observed~	NNP
cord-015021-pol2qm74	8956	1	Besides	besides	IN
cord-015021-pol2qm74	8956	2	that	that	DT
cord-015021-pol2qm74	8956	3	,	,	,
cord-015021-pol2qm74	8956	4	these	these	DT
cord-015021-pol2qm74	8956	5	persons	person	NNS
cord-015021-pol2qm74	8956	6	showed	show	VBD
cord-015021-pol2qm74	8956	7	higher	high	JJR
cord-015021-pol2qm74	8956	8	CD19cells	CD19cells	NNPS
cord-015021-pol2qm74	8956	9	amount	amount	NN
cord-015021-pol2qm74	8956	10	and	and	CC
cord-015021-pol2qm74	8956	11	Ig	ig	JJ
cord-015021-pol2qm74	8956	12	level	level	NN
cord-015021-pol2qm74	8956	13	in	in	IN
cord-015021-pol2qm74	8956	14	the	the	DT
cord-015021-pol2qm74	8956	15	blood	blood	NN
cord-015021-pol2qm74	8956	16	.	.	.
cord-015021-pol2qm74	8957	1	After	after	IN
cord-015021-pol2qm74	8957	2	Thymalin	Thymalin	NNP
cord-015021-pol2qm74	8957	3	therapy	therapy	NN
cord-015021-pol2qm74	8957	4	valid	valid	JJ
cord-015021-pol2qm74	8957	5	ii	ii	NNP
cord-015021-pol2qm74	8957	6	~	~	CD
cord-015021-pol2qm74	8957	7	rovement	rovement	NN
cord-015021-pol2qm74	8957	8	of	of	IN
cord-015021-pol2qm74	8957	9	inun	inun	NNS
cord-015021-pol2qm74	8957	10	~	~	NFP
cord-015021-pol2qm74	8957	11	e	e	NN
cord-015021-pol2qm74	8957	12	status	status	NN
cord-015021-pol2qm74	8957	13	was	be	VBD
cord-015021-pol2qm74	8957	14	discovered	discover	VBN
cord-015021-pol2qm74	8957	15	.	.	.
cord-015021-pol2qm74	8958	1	Also	also	RB
cord-015021-pol2qm74	8958	2	good	good	JJ
cord-015021-pol2qm74	8958	3	clinical	clinical	JJ
cord-015021-pol2qm74	8958	4	effect	effect	NN
cord-015021-pol2qm74	8958	5	of	of	IN
cord-015021-pol2qm74	8958	6	immunotherapy	immunotherapy	NN
cord-015021-pol2qm74	8958	7	and	and	CC
cord-015021-pol2qm74	8958	8	best	good	JJS
cord-015021-pol2qm74	8958	9	wo	wo	NN
cord-015021-pol2qm74	8959	1	~id	~id	NNP
cord-015021-pol2qm74	8959	2	healing	healing	NN
cord-015021-pol2qm74	8959	3	observed	observe	VBD
cord-015021-pol2qm74	8959	4	in	in	IN
cord-015021-pol2qm74	8959	5	80	80	CD
cord-015021-pol2qm74	8959	6	%	%	NN
cord-015021-pol2qm74	8959	7	of	of	IN
cord-015021-pol2qm74	8959	8	cases	case	NNS
cord-015021-pol2qm74	8959	9	.	.	.
cord-015021-pol2qm74	8960	1	These	these	DT
cord-015021-pol2qm74	8960	2	results	result	NNS
cord-015021-pol2qm74	8960	3	allow	allow	VBP
cord-015021-pol2qm74	8960	4	us	-PRON-	PRP
cord-015021-pol2qm74	8960	5	to	to	TO
cord-015021-pol2qm74	8960	6	propose	propose	VB
cord-015021-pol2qm74	8960	7	that	that	IN
cord-015021-pol2qm74	8960	8	the	the	DT
cord-015021-pol2qm74	8960	9	thymus	thymus	NN
cord-015021-pol2qm74	8960	10	involution	involution	NN
cord-015021-pol2qm74	8960	11	and	and	CC
cord-015021-pol2qm74	8960	12	the	the	DT
cord-015021-pol2qm74	8960	13	reduction	reduction	NN
cord-015021-pol2qm74	8960	14	of	of	IN
cord-015021-pol2qm74	8960	15	cell	cell	NN
cord-015021-pol2qm74	8960	16	-	-	HYPH
cord-015021-pol2qm74	8960	17	mediated	mediate	VBN
cord-015021-pol2qm74	8960	18	immunity	immunity	NN
cord-015021-pol2qm74	8960	19	responsiveness	responsiveness	NN
cord-015021-pol2qm74	8960	20	with	with	IN
cord-015021-pol2qm74	8960	21	disturbances	disturbance	NNS
cord-015021-pol2qm74	8960	22	of	of	IN
cord-015021-pol2qm74	8960	23	immu_uoregulatio~	immu_uoregulatio~	NNP
cord-015021-pol2qm74	8960	24	on	on	IN
cord-015021-pol2qm74	8960	25	the	the	DT
cord-015021-pol2qm74	8960	26	level	level	NN
cord-015021-pol2qm74	8960	27	of	of	IN
cord-015021-pol2qm74	8960	28	restriction	restriction	NN
cord-015021-pol2qm74	8960	29	of	of	IN
cord-015021-pol2qm74	8960	30	activated	activate	VBN
cord-015021-pol2qm74	8960	31	CD4	CD4	NNP
cord-015021-pol2qm74	8960	32	ThO	tho	NN
cord-015021-pol2qm74	8960	33	cells	cell	NNS
cord-015021-pol2qm74	8960	34	play	play	VBP
cord-015021-pol2qm74	8960	35	the	the	DT
cord-015021-pol2qm74	8960	36	most	most	RBS
cord-015021-pol2qm74	8960	37	important	important	JJ
cord-015021-pol2qm74	8960	38	role	role	NN
cord-015021-pol2qm74	8960	39	in	in	IN
cord-015021-pol2qm74	8960	40	the	the	DT
cord-015021-pol2qm74	8960	41	pathogenesis	pathogenesis	NN
cord-015021-pol2qm74	8960	42	of	of	IN
cord-015021-pol2qm74	8960	43	wound	wound	JJ
cord-015021-pol2qm74	8960	44	infections	infection	NNS
cord-015021-pol2qm74	8960	45	development	development	NN
cord-015021-pol2qm74	8960	46	in	in	IN
cord-015021-pol2qm74	8960	47	persons	person	NNS
cord-015021-pol2qm74	8960	48	with	with	IN
cord-015021-pol2qm74	8960	49	traumatic	traumatic	JJ
cord-015021-pol2qm74	8960	50	injury	injury	NN
cord-015021-pol2qm74	8960	51	.	.	.
cord-015021-pol2qm74	8961	1	Dept	Dept	NNP
cord-015021-pol2qm74	8961	2	.	.	.
cord-015021-pol2qm74	8962	1	of	of	IN
cord-015021-pol2qm74	8962	2	Immunology	Immunology	NNP
cord-015021-pol2qm74	8962	3	,	,	,
cord-015021-pol2qm74	8962	4	Military	Military	NNP
cord-015021-pol2qm74	8962	5	-	-	HYPH
cord-015021-pol2qm74	8962	6	Nedical	Nedical	NNP
cord-015021-pol2qm74	8962	7	Academy	Academy	NNP
cord-015021-pol2qm74	8962	8	,	,	,
cord-015021-pol2qm74	8962	9	Lebedeva	Lebedeva	NNP
cord-015021-pol2qm74	8962	10	Str	Str	NNP
cord-015021-pol2qm74	8962	11	.	.	NNP
cord-015021-pol2qm74	8962	12	6	6	CD
cord-015021-pol2qm74	8962	13	,	,	,
cord-015021-pol2qm74	8962	14	194175	194175	CD
cord-015021-pol2qm74	8962	15	,	,	,
cord-015021-pol2qm74	8962	16	St	St	NNP
cord-015021-pol2qm74	8962	17	.	.	NNP
cord-015021-pol2qm74	8962	18	Petersburg	Petersburg	NNP
cord-015021-pol2qm74	8962	19	,	,	,
cord-015021-pol2qm74	8962	20	Russia	Russia	NNP
cord-015021-pol2qm74	8962	21	A	a	DT
cord-015021-pol2qm74	8962	22	severe	severe	JJ
cord-015021-pol2qm74	8962	23	Impairment	impairment	NN
cord-015021-pol2qm74	8962	24	of	of	IN
cord-015021-pol2qm74	8962	25	neutrophil	neutrophil	NN
cord-015021-pol2qm74	8962	26	(	(	-LRB-
cord-015021-pol2qm74	8962	27	PMN	pmn	NN
cord-015021-pol2qm74	8962	28	)	)	-RRB-
cord-015021-pol2qm74	8962	29	function	function	NN
cord-015021-pol2qm74	8962	30	often	often	RB
cord-015021-pol2qm74	8962	31	occurs	occur	VBZ
cord-015021-pol2qm74	8962	32	following	follow	VBG
cord-015021-pol2qm74	8962	33	severe	severe	JJ
cord-015021-pol2qm74	8962	34	thermal	thermal	JJ
cord-015021-pol2qm74	8962	35	or	or	CC
cord-015021-pol2qm74	8962	36	non	non	JJ
cord-015021-pol2qm74	8962	37	-	-	JJ
cord-015021-pol2qm74	8962	38	thermal	thermal	JJ
cord-015021-pol2qm74	8962	39	traumatic	traumatic	JJ
cord-015021-pol2qm74	8962	40	Injury	injury	NN
cord-015021-pol2qm74	8962	41	.	.	.
cord-015021-pol2qm74	8963	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	8963	2	laboratory	laboratory	NN
cord-015021-pol2qm74	8963	3	has	have	VBZ
cord-015021-pol2qm74	8963	4	previously	previously	RB
cord-015021-pol2qm74	8963	5	reported	report	VBN
cord-015021-pol2qm74	8963	6	that	that	IN
cord-015021-pol2qm74	8963	7	following	follow	VBG
cord-015021-pol2qm74	8963	8	severe	severe	JJ
cord-015021-pol2qm74	8963	9	burn	burn	NN
cord-015021-pol2qm74	8963	10	or	or	CC
cord-015021-pol2qm74	8963	11	non	non	JJ
cord-015021-pol2qm74	8963	12	-	-	JJ
cord-015021-pol2qm74	8963	13	burn	burn	JJ
cord-015021-pol2qm74	8963	14	traumatic	traumatic	JJ
cord-015021-pol2qm74	8963	15	injury	injury	NN
cord-015021-pol2qm74	8963	16	the	the	DT
cord-015021-pol2qm74	8963	17	expression	expression	NN
cord-015021-pol2qm74	8963	18	of	of	IN
cord-015021-pol2qm74	8963	19	the	the	DT
cord-015021-pol2qm74	8963	20	p2	p2	NNP
cord-015021-pol2qm74	8963	21	Integrlns	Integrlns	NNP
cord-015021-pol2qm74	8963	22	(	(	-LRB-
cord-015021-pol2qm74	8963	23	CD11a	CD11a	NNS
cord-015021-pol2qm74	8963	24	,	,	,
cord-015021-pol2qm74	8963	25	b	b	NN
cord-015021-pol2qm74	8963	26	,	,	,
cord-015021-pol2qm74	8963	27	c	c	NNP
cord-015021-pol2qm74	8963	28	/	/	SYM
cord-015021-pol2qm74	8963	29	CD18	CD18	NNP
cord-015021-pol2qm74	8963	30	)	)	-RRB-
cord-015021-pol2qm74	8963	31	and	and	CC
cord-015021-pol2qm74	8963	32	the	the	DT
cord-015021-pol2qm74	8963	33	FW	FW	NNP
cord-015021-pol2qm74	8963	34	receptors	receptor	NNS
cord-015021-pol2qm74	8963	35	(	(	-LRB-
cord-015021-pol2qm74	8963	36	CD16	CD16	NNP
cord-015021-pol2qm74	8963	37	,	,	,
cord-015021-pol2qm74	8963	38	and	and	CC
cord-015021-pol2qm74	8963	39	CD32	CD32	NNP
cord-015021-pol2qm74	8963	40	)	)	-RRB-
cord-015021-pol2qm74	8963	41	were	be	VBD
cord-015021-pol2qm74	8963	42	significantly	significantly	RB
cord-015021-pol2qm74	8963	43	decreased	decrease	VBN
cord-015021-pol2qm74	8963	44	on	on	IN
cord-015021-pol2qm74	8963	45	PMNs	pmn	NNS
cord-015021-pol2qm74	8963	46	,	,	,
cord-015021-pol2qm74	8963	47	In	in	IN
cord-015021-pol2qm74	8963	48	this	this	DT
cord-015021-pol2qm74	8963	49	study	study	NN
cord-015021-pol2qm74	8963	50	,	,	,
cord-015021-pol2qm74	8963	51	the	the	DT
cord-015021-pol2qm74	8963	52	effects	effect	NNS
cord-015021-pol2qm74	8963	53	of	of	IN
cord-015021-pol2qm74	8963	54	GM	GM	NNP
cord-015021-pol2qm74	8963	55	and	and	CC
cord-015021-pol2qm74	8963	56	G	G	NNP
cord-015021-pol2qm74	8963	57	-	-	HYPH
cord-015021-pol2qm74	8963	58	CSF	CSF	NNP
cord-015021-pol2qm74	8963	59	on	on	IN
cord-015021-pol2qm74	8963	60	the	the	DT
cord-015021-pol2qm74	8963	61	expression	expression	NN
cord-015021-pol2qm74	8963	62	of	of	IN
cord-015021-pol2qm74	8963	63	the	the	DT
cord-015021-pol2qm74	8963	64	F~	F~	NNP
cord-015021-pol2qm74	8963	65	R	R	NNP
cord-015021-pol2qm74	8963	66	and	and	CC
cord-015021-pol2qm74	8963	67	the	the	DT
cord-015021-pol2qm74	8963	68	~2	~2	CD
cord-015021-pol2qm74	8963	69	Integrln	Integrln	NNP
cord-015021-pol2qm74	8963	70	family	family	NN
cord-015021-pol2qm74	8963	71	on	on	IN
cord-015021-pol2qm74	8963	72	PMNs	pmn	NNS
cord-015021-pol2qm74	8963	73	were	be	VBD
cord-015021-pol2qm74	8963	74	examined	examine	VBN
cord-015021-pol2qm74	8963	75	,	,	,
cord-015021-pol2qm74	8963	76	PMNs	pmn	NNS
cord-015021-pol2qm74	8963	77	were	be	VBD
cord-015021-pol2qm74	8963	78	obtained	obtain	VBN
cord-015021-pol2qm74	8963	79	from	from	IN
cord-015021-pol2qm74	8963	80	severe	severe	JJ
cord-015021-pol2qm74	8963	81	trauma	trauma	NN
cord-015021-pol2qm74	8963	82	(	(	-LRB-
cord-015021-pol2qm74	8963	83	initial	initial	JJ
cord-015021-pol2qm74	8963	84	APACHE	APACHE	NNP
cord-015021-pol2qm74	8963	85	II	II	NNP
cord-015021-pol2qm74	8963	86	score	score	NN
cord-015021-pol2qm74	8963	87	;	;	:
cord-015021-pol2qm74	8963	88	z	z	CD
cord-015021-pol2qm74	8963	89	10	10	CD
cord-015021-pol2qm74	8963	90	)	)	-RRB-
cord-015021-pol2qm74	8963	91	or	or	CC
cord-015021-pol2qm74	8963	92	thermal	thermal	JJ
cord-015021-pol2qm74	8963	93	injury	injury	NN
cord-015021-pol2qm74	8963	94	(	(	-LRB-
cord-015021-pol2qm74	8963	95	>	>	NFP
cord-015021-pol2qm74	8963	96	30~	30~	CD
cord-015021-pol2qm74	8963	97	;	;	:
cord-015021-pol2qm74	8963	98	total	total	JJ
cord-015021-pol2qm74	8963	99	body	body	NN
cord-015021-pol2qm74	8963	100	surface	surface	NN
cord-015021-pol2qm74	8963	101	area	area	NN
cord-015021-pol2qm74	8963	102	,	,	,
cord-015021-pol2qm74	8963	103	>	>	XX
cord-015021-pol2qm74	8963	104	15~	15~	CD
cord-015021-pol2qm74	8963	105	full	full	JJ
cord-015021-pol2qm74	8963	106	thickness	thickness	NN
cord-015021-pol2qm74	8963	107	)	)	-RRB-
cord-015021-pol2qm74	8963	108	and	and	CC
cord-015021-pol2qm74	8963	109	Incubated	incubate	VBN
cord-015021-pol2qm74	8963	110	/n	/n	NNP
cord-015021-pol2qm74	8963	111	v	v	NN
cord-015021-pol2qm74	8963	112	/	/	SYM
cord-015021-pol2qm74	8963	113	tro	tro	NN
cord-015021-pol2qm74	8963	114	with	with	IN
cord-015021-pol2qm74	8963	115	GM	GM	NNP
cord-015021-pol2qm74	8963	116	or	or	CC
cord-015021-pol2qm74	8963	117	G	G	NNP
cord-015021-pol2qm74	8963	118	-	-	HYPH
cord-015021-pol2qm74	8963	119	CSF	CSF	NNP
cord-015021-pol2qm74	8963	120	.	.	.
cord-015021-pol2qm74	8964	1	The	the	DT
cord-015021-pol2qm74	8964	2	J32	J32	NNP
cord-015021-pol2qm74	8964	3	integrins	integrin	NNS
cord-015021-pol2qm74	8964	4	or	or	CC
cord-015021-pol2qm74	8964	5	FcyR	FcyR	NNP
cord-015021-pol2qm74	8964	6	were	be	VBD
cord-015021-pol2qm74	8964	7	detected	detect	VBN
cord-015021-pol2qm74	8964	8	with	with	IN
cord-015021-pol2qm74	8964	9	monoclonal	monoclonal	JJ
cord-015021-pol2qm74	8964	10	antibodies	antibody	NNS
cord-015021-pol2qm74	8964	11	and	and	CC
cord-015021-pol2qm74	8964	12	flow	flow	NN
cord-015021-pol2qm74	8964	13	cytometry	cytometry	NN
cord-015021-pol2qm74	8964	14	.	.	.
cord-015021-pol2qm74	8965	1	GM	GM	NNP
cord-015021-pol2qm74	8965	2	end	end	NN
cord-015021-pol2qm74	8966	1	G	G	NNP
cord-015021-pol2qm74	8966	2	-	-	HYPH
cord-015021-pol2qm74	8966	3	CSF	CSF	NNP
cord-015021-pol2qm74	8966	4	Induced	induce	VBD
cord-015021-pol2qm74	8966	5	a	a	DT
cord-015021-pol2qm74	8966	6	sllght	sllght	NN
cord-015021-pol2qm74	8966	7	increase	increase	NN
cord-015021-pol2qm74	8967	1	In	in	IN
cord-015021-pol2qm74	8967	2	the	the	DT
cord-015021-pol2qm74	8967	3	percentage	percentage	NN
cord-015021-pol2qm74	8967	4	of	of	IN
cord-015021-pol2qm74	8967	5	PMNs	pmn	NNS
cord-015021-pol2qm74	8967	6	expressing	express	VBG
cord-015021-pol2qm74	8967	7	CD1	CD1	NNP
cord-015021-pol2qm74	8967	8	lb	lb	NNP
cord-015021-pol2qm74	8967	9	,	,	,
cord-015021-pol2qm74	8967	10	CD16	CD16	NNP
cord-015021-pol2qm74	8967	11	,	,	,
cord-015021-pol2qm74	8967	12	and	and	CC
cord-015021-pol2qm74	8967	13	CD18	CD18	NNP
cord-015021-pol2qm74	8967	14	while	while	IN
cord-015021-pol2qm74	8967	15	GM	GM	NNP
cord-015021-pol2qm74	8967	16	bur	bur	NN
cord-015021-pol2qm74	8967	17	not	not	RB
cord-015021-pol2qm74	8967	18	C	C	NNP
cord-015021-pol2qm74	8967	19	-	-	HYPH
cord-015021-pol2qm74	8967	20	CSF	CSF	NNP
cord-015021-pol2qm74	8967	21	Induced	induce	VBD
cord-015021-pol2qm74	8967	22	an	an	DT
cord-015021-pol2qm74	8967	23	Increase	increase	NN
cord-015021-pol2qm74	8967	24	in	in	IN
cord-015021-pol2qm74	8967	25	the	the	DT
cord-015021-pol2qm74	8967	26	percentage	percentage	NN
cord-015021-pol2qm74	8967	27	expressing	express	VBG
cord-015021-pol2qm74	8967	28	CDI	CDI	NNP
cord-015021-pol2qm74	8967	29	1	1	CD
cord-015021-pol2qm74	8967	30	a	a	NNP
cord-015021-pol2qm74	8967	31	,	,	,
cord-015021-pol2qm74	8967	32	CD1	CD1	NNP
cord-015021-pol2qm74	8967	33	lc	lc	NNP
cord-015021-pol2qm74	8967	34	,	,	,
cord-015021-pol2qm74	8967	35	and	and	CC
cord-015021-pol2qm74	8967	36	CD32	CD32	NNP
cord-015021-pol2qm74	8967	37	,	,	,
cord-015021-pol2qm74	8967	38	GM	GM	NNP
cord-015021-pol2qm74	8967	39	-	-	HYPH
cord-015021-pol2qm74	8967	40	CSF	CSF	NNP
cord-015021-pol2qm74	8967	41	and	and	CC
cord-015021-pol2qm74	8967	42	to	to	IN
cord-015021-pol2qm74	8967	43	a	a	DT
cord-015021-pol2qm74	8967	44	lesser	less	JJR
cord-015021-pol2qm74	8967	45	extent	extent	NN
cord-015021-pol2qm74	8967	46	G	G	NNP
cord-015021-pol2qm74	8967	47	-	-	HYPH
cord-015021-pol2qm74	8967	48	CSF	CSF	NNP
cord-015021-pol2qm74	8967	49	Induced	induce	VBD
cord-015021-pol2qm74	8967	50	an	an	DT
cord-015021-pol2qm74	8967	51	increase	increase	NN
cord-015021-pol2qm74	8967	52	in	in	IN
cord-015021-pol2qm74	8967	53	the	the	DT
cord-015021-pol2qm74	8967	54	density	density	NN
cord-015021-pol2qm74	8967	55	(	(	-LRB-
cord-015021-pol2qm74	8967	56	1,5	1,5	CD
cord-015021-pol2qm74	8967	57	fold	fold	NN
cord-015021-pol2qm74	8967	58	)	)	-RRB-
cord-015021-pol2qm74	8967	59	of	of	IN
cord-015021-pol2qm74	8967	60	the	the	DT
cord-015021-pol2qm74	8967	61	~2	~2	NNP
cord-015021-pol2qm74	8967	62	integrlns	integrlns	NNPS
cord-015021-pol2qm74	8967	63	on	on	IN
cord-015021-pol2qm74	8967	64	PMNs	pmn	NNS
cord-015021-pol2qm74	8967	65	from	from	IN
cord-015021-pol2qm74	8967	66	normal	normal	JJ
cord-015021-pol2qm74	8967	67	,	,	,
cord-015021-pol2qm74	8967	68	burn	burn	VB
cord-015021-pol2qm74	8967	69	,	,	,
cord-015021-pol2qm74	8967	70	and	and	CC
cord-015021-pol2qm74	8967	71	trauma	trauma	NN
cord-015021-pol2qm74	8967	72	patients	patient	NNS
cord-015021-pol2qm74	8967	73	,	,	,
cord-015021-pol2qm74	8967	74	These	these	DT
cord-015021-pol2qm74	8967	75	data	datum	NNS
cord-015021-pol2qm74	8967	76	suggest	suggest	VBP
cord-015021-pol2qm74	8967	77	that	that	IN
cord-015021-pol2qm74	8967	78	cytoklne	cytoklne	JJ
cord-015021-pol2qm74	8967	79	modulation	modulation	NN
cord-015021-pol2qm74	8967	80	with	with	IN
cord-015021-pol2qm74	8967	81	CSFs	csf	NNS
cord-015021-pol2qm74	8967	82	could	could	MD
cord-015021-pol2qm74	8967	83	have	have	VB
cord-015021-pol2qm74	8967	84	a	a	DT
cord-015021-pol2qm74	8967	85	role	role	NN
cord-015021-pol2qm74	8967	86	clinically	clinically	RB
cord-015021-pol2qm74	8967	87	in	in	IN
cord-015021-pol2qm74	8967	88	certain	certain	JJ
cord-015021-pol2qm74	8967	89	situations	situation	NNS
cord-015021-pol2qm74	8967	90	.	.	.
cord-015021-pol2qm74	8968	1	Institute	Institute	NNP
cord-015021-pol2qm74	8968	2	,	,	,
cord-015021-pol2qm74	8968	3	Dept	Dept	NNP
cord-015021-pol2qm74	8968	4	.	.	NNP
cord-015021-pol2qm74	8968	5	of	of	IN
cord-015021-pol2qm74	8968	6	Surgery	surgery	NN
cord-015021-pol2qm74	8968	7	,	,	,
cord-015021-pol2qm74	8968	8	231	231	CD
cord-015021-pol2qm74	8968	9	Bethesda	Bethesda	NNP
cord-015021-pol2qm74	8968	10	Ave	Ave	NNP
cord-015021-pol2qm74	8968	11	,	,	,
cord-015021-pol2qm74	8968	12	Cincinnati	Cincinnati	NNP
cord-015021-pol2qm74	8968	13	,	,	,
cord-015021-pol2qm74	8968	14	OH	oh	UH
cord-015021-pol2qm74	8968	15	,	,	,
cord-015021-pol2qm74	8968	16	USA	USA	NNP
cord-015021-pol2qm74	8968	17	,	,	,
cord-015021-pol2qm74	8968	18	45267	45267	CD
cord-015021-pol2qm74	8968	19	-	-	SYM
cord-015021-pol2qm74	8968	20	0558	0558	CD
cord-015021-pol2qm74	8968	21	.	.	.
cord-015021-pol2qm74	8969	1	Funl	Funl	NNS
cord-015021-pol2qm74	8969	2	~	~	NFP
cord-015021-pol2qm74	8969	3	al	al	NNP
cord-015021-pol2qm74	8969	4	Infections	Infections	NNPS
cord-015021-pol2qm74	8969	5	after	after	IN
cord-015021-pol2qm74	8969	6	Solid	Solid	NNP
cord-015021-pol2qm74	8969	7	Organ	Organ	NNP
cord-015021-pol2qm74	8969	8	Transplantatlon(SOT	Transplantatlon(SOT	NNP
cord-015021-pol2qm74	8969	9	)	)	-RRB-
cord-015021-pol2qm74	8970	1	Lewis	Lewis	NNP
cord-015021-pol2qm74	8970	2	Flint	Flint	NNP
cord-015021-pol2qm74	8970	3	,	,	,
cord-015021-pol2qm74	8970	4	MD	MD	NNP
cord-015021-pol2qm74	8970	5	and	and	CC
cord-015021-pol2qm74	8970	6	Ed,~-afd	Ed,~-afd	NNP
cord-015021-pol2qm74	8970	7	E.	E.	NNP
cord-015021-pol2qm74	8970	8	Etheredge	Etheredge	NNP
cord-015021-pol2qm74	8970	9	,	,	,
cord-015021-pol2qm74	8970	10	ME	ME	NNP
cord-015021-pol2qm74	8970	11	)	)	-RRB-
cord-015021-pol2qm74	8970	12	Dept	Dept	NNP
cord-015021-pol2qm74	8970	13	.	.	NNP
cord-015021-pol2qm74	8970	14	of	of	IN
cord-015021-pol2qm74	8970	15	Surgery	surgery	NN
cord-015021-pol2qm74	8970	16	Tullrte	Tullrte	NNP
cord-015021-pol2qm74	8970	17	Univ	Univ	NNP
cord-015021-pol2qm74	8970	18	.	.	.
cord-015021-pol2qm74	8971	1	School	School	NNP
cord-015021-pol2qm74	8971	2	of	of	IN
cord-015021-pol2qm74	8971	3	Medicine	Medicine	NNP
cord-015021-pol2qm74	8971	4	New	New	NNP
cord-015021-pol2qm74	8971	5	Orleans	Orleans	NNP
cord-015021-pol2qm74	8971	6	.	.	.
cord-015021-pol2qm74	8972	1	Louisiana	Louisiana	NNP
cord-015021-pol2qm74	8972	2	Infections	Infections	NNPS
cord-015021-pol2qm74	8972	3	contribute	contribute	VBP
cord-015021-pol2qm74	8972	4	to	to	IN
cord-015021-pol2qm74	8972	5	increased	increase	VBN
cord-015021-pol2qm74	8972	6	gra5	gra5	NNP
cord-015021-pol2qm74	8972	7	loss	loss	NN
cord-015021-pol2qm74	8972	8	and	and	CC
cord-015021-pol2qm74	8972	9	mortaliw	mortaliw	NN
cord-015021-pol2qm74	8972	10	following	follow	VBG
cord-015021-pol2qm74	8972	11	SOT	SOT	NNP
cord-015021-pol2qm74	8972	12	.	.	.
cord-015021-pol2qm74	8973	1	Pr	Pr	NNP
cord-015021-pol2qm74	8974	1	~isposing	~ispose	VBG
cord-015021-pol2qm74	8974	2	facton	facton	NN
cord-015021-pol2qm74	8974	3	include	include	VBP
cord-015021-pol2qm74	8974	4	diabetes	diabetes	NN
cord-015021-pol2qm74	8974	5	,	,	,
cord-015021-pol2qm74	8974	6	hepatitis	hepatitis	NN
cord-015021-pol2qm74	8974	7	,	,	,
cord-015021-pol2qm74	8974	8	leukopenia	leukopenia	NNP
cord-015021-pol2qm74	8974	9	,	,	,
cord-015021-pol2qm74	8974	10	cc.¢xistem	cc.¢xistem	CD
cord-015021-pol2qm74	8974	11	infection	infection	NN
cord-015021-pol2qm74	8974	12	,	,	,
cord-015021-pol2qm74	8974	13	and	and	CC
cord-015021-pol2qm74	8974	14	intense	intense	JJ
cord-015021-pol2qm74	8974	15	,	,	,
cord-015021-pol2qm74	8974	16	especially	especially	RB
cord-015021-pol2qm74	8974	17	triple	triple	JJ
cord-015021-pol2qm74	8974	18	drug	drug	NN
cord-015021-pol2qm74	8974	19	,	,	,
cord-015021-pol2qm74	8974	20	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	8974	21	.	.	.
cord-015021-pol2qm74	8975	1	Funga	Funga	NNP
cord-015021-pol2qm74	8975	2	]	]	-RRB-
cord-015021-pol2qm74	8975	3	infections	infection	NNS
cord-015021-pol2qm74	8975	4	occur	occur	VBP
cord-015021-pol2qm74	8976	1	~s	~s	NNP
cord-015021-pol2qm74	8976	2	isolated	isolated	JJ
cord-015021-pol2qm74	8976	3	conditions	condition	NNS
cord-015021-pol2qm74	8976	4	in	in	IN
cord-015021-pol2qm74	8976	5	6	6	CD
cord-015021-pol2qm74	8976	6	%	%	NN
cord-015021-pol2qm74	8976	7	and	and	CC
cord-015021-pol2qm74	8976	8	in	in	IN
cord-015021-pol2qm74	8976	9	association	association	NN
cord-015021-pol2qm74	8976	10	with	with	IN
cord-015021-pol2qm74	8976	11	bacterial	bacterial	JJ
cord-015021-pol2qm74	8976	12	infection(l	infection(l	NNP
cord-015021-pol2qm74	8976	13	1	1	CD
cord-015021-pol2qm74	8976	14	%	%	NN
cord-015021-pol2qm74	8976	15	)	)	-RRB-
cord-015021-pol2qm74	8976	16	,	,	,
cord-015021-pol2qm74	8976	17	viral	viral	JJ
cord-015021-pol2qm74	8976	18	infection(3*/.	infection(3*/.	NNP
cord-015021-pol2qm74	8976	19	)	)	-RRB-
cord-015021-pol2qm74	8976	20	,	,	,
cord-015021-pol2qm74	8976	21	and	and	CC
cord-015021-pol2qm74	8976	22	combined	combine	VBN
cord-015021-pol2qm74	8976	23	infections(It%	infections(It%	NNS
cord-015021-pol2qm74	8976	24	)	)	-RRB-
cord-015021-pol2qm74	8976	25	,	,	,
cord-015021-pol2qm74	8976	26	Candida	Candida	NNP
cord-015021-pol2qm74	8976	27	sp	sp	NN
cord-015021-pol2qm74	8976	28	.	.	.
cord-015021-pol2qm74	8977	1	is	be	VBZ
cord-015021-pol2qm74	8977	2	the	the	DT
cord-015021-pol2qm74	8977	3	most	most	RBS
cord-015021-pol2qm74	8977	4	common	common	JJ
cord-015021-pol2qm74	8977	5	fungus	fungus	NN
cord-015021-pol2qm74	8977	6	recovered	recover	VBN
cord-015021-pol2qm74	8977	7	but	but	CC
cord-015021-pol2qm74	8977	8	Aspecgillus	Aspecgillus	NNP
cord-015021-pol2qm74	8977	9	,	,	,
cord-015021-pol2qm74	8977	10	Coccidiodies	Coccidiodies	NNP
cord-015021-pol2qm74	8977	11	,	,	,
cord-015021-pol2qm74	8977	12	Cryptococcus	Cryptococcus	NNP
cord-015021-pol2qm74	8977	13	,	,	,
cord-015021-pol2qm74	8977	14	Histoplasma	Histoplasma	NNP
cord-015021-pol2qm74	8977	15	,	,	,
cord-015021-pol2qm74	8978	1	Mueor~	mueor~	CD
cord-015021-pol2qm74	8979	1	ghizopus	ghizopus	NNP
cord-015021-pol2qm74	8979	2	,	,	,
cord-015021-pol2qm74	8979	3	Tinea	Tinea	NNP
cord-015021-pol2qm74	8979	4	,	,	,
cord-015021-pol2qm74	8979	5	and	and	CC
cord-015021-pol2qm74	8979	6	ToruIop	ToruIop	NNP
cord-015021-pol2qm74	8980	1	~is	~is	NNP
cord-015021-pol2qm74	8980	2	s	s	NNP
cord-015021-pol2qm74	8980	3	?	?	.
cord-015021-pol2qm74	8980	4	.	.	.
cord-015021-pol2qm74	8981	1	also	also	RB
cord-015021-pol2qm74	8981	2	are	be	VBP
cord-015021-pol2qm74	8981	3	pathogens	pathogen	NNS
cord-015021-pol2qm74	8981	4	.	.	.
cord-015021-pol2qm74	8982	1	Clinical	clinical	JJ
cord-015021-pol2qm74	8982	2	syndromes	syndrome	NNS
cord-015021-pol2qm74	8982	3	vary	vary	VBP
cord-015021-pol2qm74	8982	4	among	among	IN
cord-015021-pol2qm74	8982	5	orga.aizms	orga.aizms	JJ
cord-015021-pol2qm74	8982	6	or	or	CC
cord-015021-pol2qm74	8982	7	may	may	MD
cord-015021-pol2qm74	8982	8	be	be	VB
cord-015021-pol2qm74	8982	9	variable	variable	JJ
cord-015021-pol2qm74	8982	10	with	with	IN
cord-015021-pol2qm74	8982	11	a	a	DT
cord-015021-pol2qm74	8982	12	single	single	JJ
cord-015021-pol2qm74	8982	13	p	p	NN
cord-015021-pol2qm74	8982	14	~	~	CD
cord-015021-pol2qm74	8982	15	tthogen	tthogen	NNP
cord-015021-pol2qm74	8982	16	,	,	,
cord-015021-pol2qm74	8982	17	For	for	IN
cord-015021-pol2qm74	8982	18	~ample	~ample	NNP
cord-015021-pol2qm74	8982	19	,	,	,
cord-015021-pol2qm74	8982	20	with	with	IN
cord-015021-pol2qm74	8982	21	aggressive	aggressive	JJ
cord-015021-pol2qm74	8982	22	immunosuppression	immunosuppression	NN
cord-015021-pol2qm74	8982	23	,	,	,
cord-015021-pol2qm74	8983	1	Candlda	Candlda	NNP
cord-015021-pol2qm74	8983	2	my	-PRON-	PRP$
cord-015021-pol2qm74	8983	3	be	be	VB
cord-015021-pol2qm74	8983	4	localized	localize	VBN
cord-015021-pol2qm74	8983	5	esophagitis	esophagitis	NN
cord-015021-pol2qm74	8983	6	or	or	CC
cord-015021-pol2qm74	8983	7	cystitis	cystitis	NN
cord-015021-pol2qm74	8983	8	or	or	CC
cord-015021-pol2qm74	8983	9	systemically	systemically	RB
cord-015021-pol2qm74	8983	10	iavaslve	iavaslve	VB
cord-015021-pol2qm74	8983	11	with	with	IN
cord-015021-pol2qm74	8983	12	an	an	DT
cord-015021-pol2qm74	8983	13	associated	associated	JJ
cord-015021-pol2qm74	8983	14	high	high	JJ
cord-015021-pol2qm74	8983	15	mortality	mortality	NN
cord-015021-pol2qm74	8983	16	.	.	.
cord-015021-pol2qm74	8984	1	AspergilIus	AspergilIus	NNP
cord-015021-pol2qm74	8984	2	presents	present	VBZ
cord-015021-pol2qm74	8984	3	~	~	NFP
cord-015021-pol2qm74	8984	4	a	a	DT
cord-015021-pol2qm74	8984	5	diffuse	diffuse	JJ
cord-015021-pol2qm74	8984	6	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8984	7	while	while	IN
cord-015021-pol2qm74	8984	8	Cryptococcus	Cryptococcus	NNP
cord-015021-pol2qm74	8984	9	causes	cause	VBZ
cord-015021-pol2qm74	8984	10	pulmonary	pulmonary	NN
cord-015021-pol2qm74	8984	11	and	and	CC
cord-015021-pol2qm74	8984	12	centrad	centrad	NN
cord-015021-pol2qm74	8984	13	nervons	nervon	VBZ
cord-015021-pol2qm74	8984	14	sy'Stem	sy'stem	CD
cord-015021-pol2qm74	8984	15	infection	infection	NN
cord-015021-pol2qm74	8984	16	,	,	,
cord-015021-pol2qm74	8984	17	Clinical	clinical	JJ
cord-015021-pol2qm74	8984	18	examination	examination	NN
cord-015021-pol2qm74	8984	19	,	,	,
cord-015021-pol2qm74	8984	20	CT	CT	NNP
cord-015021-pol2qm74	8984	21	scanning	scanning	NN
cord-015021-pol2qm74	8984	22	and	and	CC
cord-015021-pol2qm74	8984	23	aggressive	aggressive	JJ
cord-015021-pol2qm74	8984	24	sampling	sampling	NN
cord-015021-pol2qm74	8984	25	for	for	IN
cord-015021-pol2qm74	8984	26	c'ultures	c'ultures	NNP
cord-015021-pol2qm74	8984	27	a.s	a.s	NNP
cord-015021-pol2qm74	8984	28	wall	wall	NN
cord-015021-pol2qm74	8984	29	as	as	IN
cord-015021-pol2qm74	8984	30	serologic	serologic	NNP
cord-015021-pol2qm74	8984	31	tests	test	NNS
cord-015021-pol2qm74	8984	32	contribute	contribute	VBP
cord-015021-pol2qm74	8984	33	to	to	IN
cord-015021-pol2qm74	8984	34	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8984	35	.	.	.
cord-015021-pol2qm74	8985	1	Empiric	empiric	RB
cord-015021-pol2qm74	8985	2	the	the	DT
cord-015021-pol2qm74	8986	1	~py	~py	NNP
cord-015021-pol2qm74	8986	2	is	be	VBZ
cord-015021-pol2qm74	8986	3	ind',cated	ind',cate	VBN
cord-015021-pol2qm74	8986	4	where	where	WRB
cord-015021-pol2qm74	8986	5	there	there	EX
cord-015021-pol2qm74	8986	6	is	be	VBZ
cord-015021-pol2qm74	8986	7	a	a	DT
cord-015021-pol2qm74	8986	8	high	high	JJ
cord-015021-pol2qm74	8986	9	level	level	NN
cord-015021-pol2qm74	8986	10	of	of	IN
cord-015021-pol2qm74	8986	11	suspicion	suspicion	NN
cord-015021-pol2qm74	8986	12	.	.	.
cord-015021-pol2qm74	8987	1	Preventlon	Preventlon	NNP
cord-015021-pol2qm74	8987	2	of	of	IN
cord-015021-pol2qm74	8987	3	Ca.adlda	ca.adlda	CD
cord-015021-pol2qm74	8987	4	izfection	izfection	NN
cord-015021-pol2qm74	8987	5	is	be	VBZ
cord-015021-pol2qm74	8987	6	~ci	~ci	NNP
cord-015021-pol2qm74	8987	7	~	~	NFP
cord-015021-pol2qm74	8987	8	itated	itate	VBN
cord-015021-pol2qm74	8987	9	by	by	IN
cord-015021-pol2qm74	8987	10	early	early	JJ
cord-015021-pol2qm74	8987	11	remov	remov	NN
cord-015021-pol2qm74	8987	12	-	-	HYPH
cord-015021-pol2qm74	8987	13	a.1	a.1	CD
cord-015021-pol2qm74	8987	14	of	of	IN
cord-015021-pol2qm74	8987	15	central	central	JJ
cord-015021-pol2qm74	8987	16	}	}	-RRB-
cord-015021-pol2qm74	8987	17	ants	ant	NNS
cord-015021-pol2qm74	8987	18	,	,	,
cord-015021-pol2qm74	8987	19	ca	ca	NNP
cord-015021-pol2qm74	8987	20	~	~	CD
cord-015021-pol2qm74	8987	21	hetess	hetess	NN
cord-015021-pol2qm74	8987	22	and	and	CC
cord-015021-pol2qm74	8987	23	stents	stent	NNS
cord-015021-pol2qm74	8987	24	as	as	RB
cord-015021-pol2qm74	8987	25	well	well	RB
cord-015021-pol2qm74	8987	26	as	as	IN
cord-015021-pol2qm74	8987	27	by	by	IN
cord-015021-pol2qm74	8987	28	the	the	DT
cord-015021-pol2qm74	8987	29	use	use	NN
cord-015021-pol2qm74	8987	30	of	of	IN
cord-015021-pol2qm74	8987	31	oral	oral	JJ
cord-015021-pol2qm74	8987	32	nystatin	nystatin	NNS
cord-015021-pol2qm74	8987	33	.	.	.
cord-015021-pol2qm74	8988	1	Amphotericin	Amphotericin	NNP
cord-015021-pol2qm74	8988	2	]	]	-RRB-
cord-015021-pol2qm74	8988	3	~	~	NFP
cord-015021-pol2qm74	8988	4	remains	remain	VBZ
cord-015021-pol2qm74	8988	5	the	the	DT
cord-015021-pol2qm74	8988	6	drug	drug	NN
cord-015021-pol2qm74	8988	7	of	of	IN
cord-015021-pol2qm74	8988	8	choice	choice	NN
cord-015021-pol2qm74	8988	9	for	for	IN
cord-015021-pol2qm74	8988	10	treatment	treatment	NN
cord-015021-pol2qm74	8988	11	of	of	IN
cord-015021-pol2qm74	8988	12	in.save	in.save	NNP
cord-015021-pol2qm74	8988	13	fungd	fungd	NN
cord-015021-pol2qm74	8988	14	infection	infection	NN
cord-015021-pol2qm74	8988	15	,	,	,
cord-015021-pol2qm74	8988	16	Surgical	surgical	JJ
cord-015021-pol2qm74	8988	17	resection	resection	NN
cord-015021-pol2qm74	8988	18	of	of	IN
cord-015021-pol2qm74	8988	19	infectious	infectious	JJ
cord-015021-pol2qm74	8988	20	loci	locus	NNS
cord-015021-pol2qm74	8988	21	in	in	IN
cord-015021-pol2qm74	8988	22	the	the	DT
cord-015021-pol2qm74	8988	23	lung	lung	NN
cord-015021-pol2qm74	8988	24	and	and	CC
cord-015021-pol2qm74	8988	25	brain	brain	NN
cord-015021-pol2qm74	8988	26	is	be	VBZ
cord-015021-pol2qm74	8988	27	indicated	indicate	VBN
cord-015021-pol2qm74	8988	28	in	in	IN
cord-015021-pol2qm74	8988	29	selected	select	VBN
cord-015021-pol2qm74	8988	30	patientS.	patients.	NN
cord-015021-pol2qm74	8989	1	The	the	DT
cord-015021-pol2qm74	8989	2	main	main	JJ
cord-015021-pol2qm74	8989	3	problems	problem	NNS
cord-015021-pol2qm74	8989	4	of	of	IN
cord-015021-pol2qm74	8989	5	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8989	6	in	in	IN
cord-015021-pol2qm74	8989	7	lower	low	JJR
cord-015021-pol2qm74	8989	8	respirator-	respirator-	NNS
cord-015021-pol2qm74	8989	9	)	)	-RRB-
cord-015021-pol2qm74	8989	10	,	,	,
cord-015021-pol2qm74	8989	11	tract	tract	JJ
cord-015021-pol2qm74	8989	12	infection	infection	NN
cord-015021-pol2qm74	8989	13	are	be	VBP
cord-015021-pol2qm74	8989	14	the	the	DT
cord-015021-pol2qm74	8989	15	differentation	differentation	NN
cord-015021-pol2qm74	8989	16	of	of	IN
cord-015021-pol2qm74	8989	17	infection	infection	NN
cord-015021-pol2qm74	8989	18	from	from	IN
cord-015021-pol2qm74	8989	19	colonization	colonization	NN
cord-015021-pol2qm74	8989	20	or	or	CC
cord-015021-pol2qm74	8989	21	contamination	contamination	NN
cord-015021-pol2qm74	8989	22	,	,	,
cord-015021-pol2qm74	8989	23	and	and	CC
cord-015021-pol2qm74	8989	24	the	the	DT
cord-015021-pol2qm74	8989	25	isolation	isolation	NN
cord-015021-pol2qm74	8989	26	of	of	IN
cord-015021-pol2qm74	8989	27	a	a	DT
cord-015021-pol2qm74	8989	28	reliable	reliable	JJ
cord-015021-pol2qm74	8989	29	and	and	CC
cord-015021-pol2qm74	8989	30	true	true	JJ
cord-015021-pol2qm74	8989	31	pathogen	pathogen	NN
cord-015021-pol2qm74	8989	32	.	.	.
cord-015021-pol2qm74	8990	1	Expectorated	expectorated	JJ
cord-015021-pol2qm74	8990	2	sputum	sputum	NN
cord-015021-pol2qm74	8990	3	may	may	MD
cord-015021-pol2qm74	8990	4	be	be	VB
cord-015021-pol2qm74	8990	5	unreliable	unreliable	JJ
cord-015021-pol2qm74	8990	6	in	in	IN
cord-015021-pol2qm74	8990	7	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8990	8	,	,	,
cord-015021-pol2qm74	8990	9	because	because	IN
cord-015021-pol2qm74	8990	10	of	of	IN
cord-015021-pol2qm74	8990	11	contamination	contamination	NN
cord-015021-pol2qm74	8990	12	by	by	IN
cord-015021-pol2qm74	8990	13	oropharyngeal	oropharyngeal	JJ
cord-015021-pol2qm74	8990	14	flora	flora	NNS
cord-015021-pol2qm74	8990	15	.	.	.
cord-015021-pol2qm74	8991	1	Although	although	IN
cord-015021-pol2qm74	8991	2	blood	blood	NN
cord-015021-pol2qm74	8991	3	cultures	culture	NNS
cord-015021-pol2qm74	8991	4	may	may	MD
cord-015021-pol2qm74	8991	5	be	be	VB
cord-015021-pol2qm74	8991	6	negative	negative	JJ
cord-015021-pol2qm74	8991	7	,	,	,
cord-015021-pol2qm74	8991	8	they	-PRON-	PRP
cord-015021-pol2qm74	8991	9	provide	provide	VBP
cord-015021-pol2qm74	8991	10	a	a	DT
cord-015021-pol2qm74	8991	11	precise	precise	JJ
cord-015021-pol2qm74	8991	12	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8991	13	and	and	CC
cord-015021-pol2qm74	8991	14	should	should	MD
cord-015021-pol2qm74	8991	15	be	be	VB
cord-015021-pol2qm74	8991	16	obtained	obtain	VBN
cord-015021-pol2qm74	8991	17	in	in	IN
cord-015021-pol2qm74	8991	18	all	all	DT
cord-015021-pol2qm74	8991	19	pneumonias	pneumonia	NNS
cord-015021-pol2qm74	8991	20	.	.	.
cord-015021-pol2qm74	8992	1	Other	other	JJ
cord-015021-pol2qm74	8992	2	more	more	JJR
cord-015021-pol2qm74	8992	3	invasive	invasive	JJ
cord-015021-pol2qm74	8992	4	procedures	procedure	NNS
cord-015021-pol2qm74	8992	5	are	be	VBP
cord-015021-pol2qm74	8992	6	transtracheal	transtracheal	NN
cord-015021-pol2qm74	8992	7	needle	needle	NN
cord-015021-pol2qm74	8992	8	aspiration	aspiration	NN
cord-015021-pol2qm74	8992	9	,	,	,
cord-015021-pol2qm74	8992	10	fibrobronchoscopic	fibrobronchoscopic	JJ
cord-015021-pol2qm74	8992	11	techniques	technique	NNS
cord-015021-pol2qm74	8992	12	including	include	VBG
cord-015021-pol2qm74	8992	13	protected	protect	VBN
cord-015021-pol2qm74	8992	14	specimen	specimen	JJ
cord-015021-pol2qm74	8992	15	brush	brush	NN
cord-015021-pol2qm74	8992	16	and	and	CC
cord-015021-pol2qm74	8992	17	bronchoalveolar	bronchoalveolar	NNP
cord-015021-pol2qm74	8992	18	lavage	lavage	NN
cord-015021-pol2qm74	8992	19	with	with	IN
cord-015021-pol2qm74	8992	20	quantitative	quantitative	JJ
cord-015021-pol2qm74	8992	21	culturing	culturing	NN
cord-015021-pol2qm74	8992	22	and	and	CC
cord-015021-pol2qm74	8992	23	cytological	cytological	JJ
cord-015021-pol2qm74	8992	24	analysis	analysis	NN
cord-015021-pol2qm74	8992	25	,	,	,
cord-015021-pol2qm74	8992	26	transthoracic	transthoracic	NNP
cord-015021-pol2qm74	8992	27	needle	needle	NN
cord-015021-pol2qm74	8992	28	aspiration	aspiration	NN
cord-015021-pol2qm74	8992	29	,	,	,
cord-015021-pol2qm74	8992	30	thoracoscopy	thoracoscopy	NNP
cord-015021-pol2qm74	8992	31	-guided	-guided	JJ
cord-015021-pol2qm74	8992	32	biopsy	biopsy	NN
cord-015021-pol2qm74	8992	33	and	and	CC
cord-015021-pol2qm74	8992	34	open	open	JJ
cord-015021-pol2qm74	8992	35	lung	lung	NN
cord-015021-pol2qm74	8992	36	biopsy	biopsy	NN
cord-015021-pol2qm74	8992	37	.	.	.
cord-015021-pol2qm74	8993	1	Recently	recently	RB
cord-015021-pol2qm74	8993	2	M.	M.	NNP
cord-015021-pol2qm74	8993	3	E1-Ebiary	E1-Ebiary	NNP
cord-015021-pol2qm74	8993	4	,	,	,
cord-015021-pol2qm74	8993	5	A.	A.	NNP
cord-015021-pol2qm74	8993	6	Torres	Torres	NNP
cord-015021-pol2qm74	8993	7	et	et	NNP
cord-015021-pol2qm74	8993	8	al	al	NNP
cord-015021-pol2qm74	8993	9	,	,	,
cord-015021-pol2qm74	8993	10	1993	1993	CD
cord-015021-pol2qm74	8993	11	reported	report	VBD
cord-015021-pol2qm74	8993	12	quantitative	quantitative	JJ
cord-015021-pol2qm74	8993	13	cultures	culture	NNS
cord-015021-pol2qm74	8993	14	of	of	IN
cord-015021-pol2qm74	8993	15	endotracheal	endotracheal	NN
cord-015021-pol2qm74	8993	16	aspirates	aspirate	NNS
cord-015021-pol2qm74	8993	17	for	for	IN
cord-015021-pol2qm74	8993	18	the	the	DT
cord-015021-pol2qm74	8993	19	diagnosis	diagnosis	NN
cord-015021-pol2qm74	8993	20	of	of	IN
cord-015021-pol2qm74	8993	21	ventilator	ventilator	NN
cord-015021-pol2qm74	8993	22	-	-	HYPH
cord-015021-pol2qm74	8993	23	associated	associate	VBN
cord-015021-pol2qm74	8993	24	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8993	25	offering	offer	VBG
cord-015021-pol2qm74	8993	26	reliable	reliable	JJ
cord-015021-pol2qm74	8993	27	results	result	NNS
cord-015021-pol2qm74	8993	28	in	in	IN
cord-015021-pol2qm74	8993	29	these	these	DT
cord-015021-pol2qm74	8993	30	patients	patient	NNS
cord-015021-pol2qm74	8993	31	and	and	CC
cord-015021-pol2qm74	8993	32	should	should	MD
cord-015021-pol2qm74	8993	33	be	be	VB
cord-015021-pol2qm74	8993	34	further	further	RB
cord-015021-pol2qm74	8993	35	investigated	investigate	VBN
cord-015021-pol2qm74	8993	36	.	.	.
cord-015021-pol2qm74	8994	1	Any	any	DT
cord-015021-pol2qm74	8994	2	invasive	invasive	JJ
cord-015021-pol2qm74	8994	3	procedure	procedure	NN
cord-015021-pol2qm74	8994	4	in	in	IN
cord-015021-pol2qm74	8994	5	a	a	DT
cord-015021-pol2qm74	8994	6	severely	severely	RB
cord-015021-pol2qm74	8994	7	ill	ill	JJ
cord-015021-pol2qm74	8994	8	patient	patient	NN
cord-015021-pol2qm74	8994	9	should	should	MD
cord-015021-pol2qm74	8994	10	be	be	VB
cord-015021-pol2qm74	8994	11	carefully	carefully	RB
cord-015021-pol2qm74	8994	12	directed	direct	VBN
cord-015021-pol2qm74	8994	13	weighing	weigh	VBG
cord-015021-pol2qm74	8994	14	the	the	DT
cord-015021-pol2qm74	8994	15	risks	risk	NNS
cord-015021-pol2qm74	8994	16	as	as	RB
cord-015021-pol2qm74	8994	17	well	well	RB
cord-015021-pol2qm74	8994	18	as	as	IN
cord-015021-pol2qm74	8994	19	the	the	DT
cord-015021-pol2qm74	8994	20	benefits	benefit	NNS
cord-015021-pol2qm74	8994	21	,	,	,
cord-015021-pol2qm74	8994	22	whilst	whilst	IN
cord-015021-pol2qm74	8994	23	taking	take	VBG
cord-015021-pol2qm74	8994	24	the	the	DT
cord-015021-pol2qm74	8994	25	underlying	underlie	VBG
cord-015021-pol2qm74	8994	26	diseases	disease	NNS
cord-015021-pol2qm74	8994	27	and	and	CC
cord-015021-pol2qm74	8994	28	expected	expect	VBN
cord-015021-pol2qm74	8994	29	survival	survival	NN
cord-015021-pol2qm74	8994	30	into	into	IN
cord-015021-pol2qm74	8994	31	consideration	consideration	NN
cord-015021-pol2qm74	8994	32	.	.	.
cord-015021-pol2qm74	8995	1	-Current	-Current	:
cord-015021-pol2qm74	8995	2	therapeutic	therapeutic	JJ
cord-015021-pol2qm74	8995	3	approach	approach	NN
cord-015021-pol2qm74	8995	4	is	be	VBZ
cord-015021-pol2qm74	8995	5	based	base	VBN
cord-015021-pol2qm74	8995	6	mainly	mainly	RB
cord-015021-pol2qm74	8995	7	on	on	IN
cord-015021-pol2qm74	8995	8	monotherapy	monotherapy	NN
cord-015021-pol2qm74	8995	9	with	with	IN
cord-015021-pol2qm74	8995	10	broad	broad	JJ
cord-015021-pol2qm74	8995	11	spectrum	spectrum	NN
cord-015021-pol2qm74	8995	12	antibiotics	antibiotic	NNS
cord-015021-pol2qm74	8995	13	.	.	.
cord-015021-pol2qm74	8996	1	Combination	combination	NN
cord-015021-pol2qm74	8996	2	therapy	therapy	NN
cord-015021-pol2qm74	8996	3	is	be	VBZ
cord-015021-pol2qm74	8996	4	apparently	apparently	RB
cord-015021-pol2qm74	8996	5	indicated	indicate	VBN
cord-015021-pol2qm74	8996	6	only	only	RB
cord-015021-pol2qm74	8996	7	in	in	IN
cord-015021-pol2qm74	8996	8	P.	P.	NNP
cord-015021-pol2qm74	8996	9	aeruginosa	aeruginosa	NN
cord-015021-pol2qm74	8996	10	infections	infection	NNS
cord-015021-pol2qm74	8996	11	and	and	CC
cord-015021-pol2qm74	8996	12	severe	severe	JJ
cord-015021-pol2qm74	8996	13	S.	S.	NNP
cord-015021-pol2qm74	8996	14	aureus	aureus	NN
cord-015021-pol2qm74	8996	15	pneumonia	pneumonia	NN
cord-015021-pol2qm74	8996	16	.	.	.
cord-015021-pol2qm74	8996	17	 	 	_SP
cord-015021-pol2qm74	8997	1	Graft	graft	NN
cord-015021-pol2qm74	8997	2	infection	infection	NN
cord-015021-pol2qm74	8997	3	can	can	MD
cord-015021-pol2qm74	8997	4	lead	lead	VB
cord-015021-pol2qm74	8997	5	to	to	IN
cord-015021-pol2qm74	8997	6	fulminant	fulminant	JJ
cord-015021-pol2qm74	8997	7	graft	graft	NN
cord-015021-pol2qm74	8997	8	failure	failure	NN
cord-015021-pol2qm74	8997	9	or	or	CC
cord-015021-pol2qm74	8997	10	rapid	rapid	JJ
cord-015021-pol2qm74	8997	11	progressive	progressive	JJ
cord-015021-pol2qm74	8997	12	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	8997	13	.	.	.
cord-015021-pol2qm74	8998	1	For	for	IN
cord-015021-pol2qm74	8998	2	prevention	prevention	NN
cord-015021-pol2qm74	8998	3	of	of	IN
cord-015021-pol2qm74	8998	4	graft	graft	NN
cord-015021-pol2qm74	8998	5	infection	infection	NN
cord-015021-pol2qm74	8998	6	immunoprophylaxis	immunoprophylaxis	NNP
cord-015021-pol2qm74	8998	7	,	,	,
cord-015021-pol2qm74	8998	8	i	i	PRP
cord-015021-pol2qm74	8998	9	,	,	,
cord-015021-pol2qm74	8998	10	e	e	NNP
cord-015021-pol2qm74	8998	11	.	.	NNP
cord-015021-pol2qm74	8998	12	administration	administration	NNP
cord-015021-pol2qm74	8998	13	of	of	IN
cord-015021-pol2qm74	8998	14	human	human	NNP
cord-015021-pol2qm74	8998	15	polyclonal	polyclonal	NNP
cord-015021-pol2qm74	8998	16	anti	anti	NNP
cord-015021-pol2qm74	8998	17	HBs	HBs	NNP
cord-015021-pol2qm74	8998	18	hypedmmunoglobuTin	hypedmmunoglobuTin	NNP
cord-015021-pol2qm74	8998	19	(	(	-LRB-
cord-015021-pol2qm74	8998	20	HIG	HIG	NNP
cord-015021-pol2qm74	8998	21	)	)	-RRB-
cord-015021-pol2qm74	8998	22	,	,	,
cord-015021-pol2qm74	8998	23	starting	start	VBG
cord-015021-pol2qm74	8998	24	in	in	IN
cord-015021-pol2qm74	8998	25	the	the	DT
cord-015021-pol2qm74	8998	26	anhepatic	anhepatic	JJ
cord-015021-pol2qm74	8998	27	phase	phase	NN
cord-015021-pol2qm74	8998	28	during	during	IN
cord-015021-pol2qm74	8998	29	operation	operation	NN
cord-015021-pol2qm74	8998	30	,	,	,
cord-015021-pol2qm74	8998	31	has	have	VBZ
cord-015021-pol2qm74	8998	32	proved	prove	VBN
cord-015021-pol2qm74	8998	33	to	to	TO
cord-015021-pol2qm74	8998	34	be	be	VB
cord-015021-pol2qm74	8998	35	at	at	IN
cord-015021-pol2qm74	8998	36	least	least	JJS
cord-015021-pol2qm74	8998	37	partially	partially	RB
cord-015021-pol2qm74	8998	38	succesful	succesful	JJ
cord-015021-pol2qm74	8998	39	when	when	WRB
cord-015021-pol2qm74	8998	40	performed	perform	VBN
cord-015021-pol2qm74	8998	41	on	on	IN
cord-015021-pol2qm74	8998	42	a	a	DT
cord-015021-pol2qm74	8998	43	long	long	JJ
cord-015021-pol2qm74	8998	44	term	term	NN
cord-015021-pol2qm74	8998	45	basis	basis	NN
cord-015021-pol2qm74	8998	46	.	.	.
cord-015021-pol2qm74	8999	1	From	from	IN
cord-015021-pol2qm74	8999	2	a	a	DT
cord-015021-pol2qm74	8999	3	total	total	NN
cord-015021-pol2qm74	8999	4	of	of	IN
cord-015021-pol2qm74	8999	5	415	415	CD
cord-015021-pol2qm74	8999	6	OLT	OLT	NNP
cord-015021-pol2qm74	8999	7	in	in	IN
cord-015021-pol2qm74	8999	8	adult	adult	NN
cord-015021-pol2qm74	8999	9	patients	patient	NNS
cord-015021-pol2qm74	8999	10	100	100	CD
cord-015021-pol2qm74	8999	11	OLT	OLT	NNP
cord-015021-pol2qm74	8999	12	were	be	VBD
cord-015021-pol2qm74	8999	13	performed	perform	VBN
cord-015021-pol2qm74	8999	14	for	for	IN
cord-015021-pol2qm74	8999	15	HBsAg	hbsag	ADD
cord-015021-pol2qm74	8999	16	positive	positive	JJ
cord-015021-pol2qm74	8999	17	liver	liver	NN
cord-015021-pol2qm74	8999	18	disease	disease	NN
cord-015021-pol2qm74	8999	19	(	(	-LRB-
cord-015021-pol2qm74	8999	20	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	8999	21	n=86	n=86	VBN
cord-015021-pol2qm74	8999	22	,	,	,
cord-015021-pol2qm74	8999	23	fulminant	fulminant	JJ
cord-015021-pol2qm74	8999	24	liver	liver	NN
cord-015021-pol2qm74	8999	25	failure	failure	NN
cord-015021-pol2qm74	8999	26	n=8	n=8	NN
cord-015021-pol2qm74	8999	27	,	,	,
cord-015021-pol2qm74	8999	28	retransplantation	retransplantation	NNP
cord-015021-pol2qm74	8999	29	n=6	n=6	NNP
cord-015021-pol2qm74	8999	30	)	)	-RRB-
cord-015021-pol2qm74	8999	31	in	in	IN
cord-015021-pol2qm74	8999	32	94	94	CD
cord-015021-pol2qm74	8999	33	pat	pat	NNS
cord-015021-pol2qm74	8999	34	.	.	.
cord-015021-pol2qm74	9000	1	All	all	DT
cord-015021-pol2qm74	9000	2	pat	pat	VBP
cord-015021-pol2qm74	9000	3	.	.	.
cord-015021-pol2qm74	9001	1	received	receive	VBD
cord-015021-pol2qm74	9001	2	10.000	10.000	CD
cord-015021-pol2qm74	9001	3	U	U	NNP
cord-015021-pol2qm74	9001	4	HIG	HIG	NNP
cord-015021-pol2qm74	9001	5	in	in	IN
cord-015021-pol2qm74	9001	6	the	the	DT
cord-015021-pol2qm74	9001	7	anhepatic	anhepatic	JJ
cord-015021-pol2qm74	9001	8	phase	phase	NN
cord-015021-pol2qm74	9001	9	and	and	CC
cord-015021-pol2qm74	9001	10	2.000	2.000	CD
cord-015021-pol2qm74	9001	11	U	u	NN
cord-015021-pol2qm74	9001	12	/	/	SYM
cord-015021-pol2qm74	9001	13	per	per	IN
cord-015021-pol2qm74	9001	14	day	day	NN
cord-015021-pol2qm74	9001	15	for	for	IN
cord-015021-pol2qm74	9001	16	the	the	DT
cord-015021-pol2qm74	9001	17	first	first	JJ
cord-015021-pol2qm74	9001	18	week	week	NN
cord-015021-pol2qm74	9001	19	.	.	.
cord-015021-pol2qm74	9002	1	A	a	DT
cord-015021-pol2qm74	9002	2	small	small	JJ
cord-015021-pol2qm74	9002	3	group	group	NN
cord-015021-pol2qm74	9002	4	of	of	IN
cord-015021-pol2qm74	9002	5	9	9	CD
cord-015021-pol2qm74	9002	6	pat	pat	NN
cord-015021-pol2qm74	9002	7	.	.	.
cord-015021-pol2qm74	9003	1	received	receive	VBD
cord-015021-pol2qm74	9003	2	HIG	HIG	NNP
cord-015021-pol2qm74	9003	3	only	only	RB
cord-015021-pol2qm74	9003	4	for	for	IN
cord-015021-pol2qm74	9003	5	I	-PRON-	PRP
cord-015021-pol2qm74	9003	6	week	week	NN
cord-015021-pol2qm74	9003	7	(	(	-LRB-
cord-015021-pol2qm74	9003	8	short	short	JJ
cord-015021-pol2qm74	9003	9	term	term	NN
cord-015021-pol2qm74	9003	10	immunoprophylaxis	immunoprophylaxis	NNP
cord-015021-pol2qm74	9003	11	)	)	-RRB-
cord-015021-pol2qm74	9003	12	,	,	,
cord-015021-pol2qm74	9003	13	in	in	IN
cord-015021-pol2qm74	9003	14	all	all	DT
cord-015021-pol2qm74	9003	15	other	other	JJ
cord-015021-pol2qm74	9003	16	pat	pat	NNP
cord-015021-pol2qm74	9003	17	.	.	.
cord-015021-pol2qm74	9004	1	HIG	HIG	NNP
cord-015021-pol2qm74	9004	2	is	be	VBZ
cord-015021-pol2qm74	9004	3	administered	administer	VBN
cord-015021-pol2qm74	9004	4	on	on	IN
cord-015021-pol2qm74	9004	5	a	a	DT
cord-015021-pol2qm74	9004	6	long	long	JJ
cord-015021-pol2qm74	9004	7	term	term	NN
cord-015021-pol2qm74	9004	8	basis	basis	NN
cord-015021-pol2qm74	9004	9	to	to	TO
cord-015021-pol2qm74	9004	10	keep	keep	VB
cord-015021-pol2qm74	9004	11	anti	anti	JJ
cord-015021-pol2qm74	9004	12	HBs	hbs	NN
cord-015021-pol2qm74	9004	13	serum	serum	NN
cord-015021-pol2qm74	9004	14	levels	level	NNS
cord-015021-pol2qm74	9004	15	above	above	IN
cord-015021-pol2qm74	9004	16	100	100	CD
cord-015021-pol2qm74	9004	17	UII	UII	NNP
cord-015021-pol2qm74	9004	18	or	or	CC
cord-015021-pol2qm74	9004	19	until	until	IN
cord-015021-pol2qm74	9004	20	graft	graft	NN
cord-015021-pol2qm74	9004	21	infection	infection	NN
cord-015021-pol2qm74	9004	22	occurs	occur	VBZ
cord-015021-pol2qm74	9004	23	(	(	-LRB-
cord-015021-pol2qm74	9004	24	long	long	JJ
cord-015021-pol2qm74	9004	25	term	term	NN
cord-015021-pol2qm74	9004	26	immunoprophylaxis);One	immunoprophylaxis);one	CD
cord-015021-pol2qm74	9004	27	-	-	HYPH
cord-015021-pol2qm74	9004	28	year	year	NN
cord-015021-pol2qm74	9004	29	survival	survival	NN
cord-015021-pol2qm74	9004	30	rates	rate	NNS
cord-015021-pol2qm74	9004	31	are	be	VBP
cord-015021-pol2qm74	9004	32	100	100	CD
cord-015021-pol2qm74	9004	33	%	%	NN
cord-015021-pol2qm74	9004	34	in	in	IN
cord-015021-pol2qm74	9004	35	pat	pat	NNP
cord-015021-pol2qm74	9004	36	.	.	.
cord-015021-pol2qm74	9005	1	who	who	WP
cord-015021-pol2qm74	9005	2	were	be	VBD
cord-015021-pol2qm74	9005	3	transplanted	transplant	VBN
cord-015021-pol2qm74	9005	4	for	for	IN
cord-015021-pol2qm74	9005	5	fulminant	fulminant	JJ
cord-015021-pol2qm74	9005	6	hepatitis	hepatitis	NN
cord-015021-pol2qm74	9005	7	,	,	,
cord-015021-pol2qm74	9005	8	96	96	CD
cord-015021-pol2qm74	9005	9	%	%	NN
cord-015021-pol2qm74	9005	10	in	in	IN
cord-015021-pol2qm74	9005	11	pat	pat	NNP
cord-015021-pol2qm74	9005	12	.	.	.
cord-015021-pol2qm74	9006	1	with	with	IN
cord-015021-pol2qm74	9006	2	cirrhosis	cirrhosis	NN
cord-015021-pol2qm74	9006	3	and	and	CC
cord-015021-pol2qm74	9006	4	long	long	JJ
cord-015021-pol2qm74	9006	5	term	term	NN
cord-015021-pol2qm74	9006	6	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	9006	7	,	,	,
cord-015021-pol2qm74	9006	8	and	and	CC
cord-015021-pol2qm74	9006	9	78	78	CD
cord-015021-pol2qm74	9006	10	%	%	NN
cord-015021-pol2qm74	9006	11	ir~	ir~	NN
cord-015021-pol2qm74	9006	12	pat	pat	NNP
cord-015021-pol2qm74	9006	13	.	.	.
cord-015021-pol2qm74	9007	1	with	with	IN
cord-015021-pol2qm74	9007	2	short	short	JJ
cord-015021-pol2qm74	9007	3	term	term	NN
cord-015021-pol2qm74	9007	4	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	9007	5	.	.	.
cord-015021-pol2qm74	9008	1	All	all	DT
cord-015021-pol2qm74	9008	2	fatalities	fatality	NNS
cord-015021-pol2qm74	9008	3	were	be	VBD
cord-015021-pol2qm74	9008	4	related	relate	VBN
cord-015021-pol2qm74	9008	5	to	to	IN
cord-015021-pol2qm74	9008	6	HBV	HBV	NNP
cord-015021-pol2qm74	9008	7	graft	graft	NN
cord-015021-pol2qm74	9008	8	infection	infection	NN
cord-015021-pol2qm74	9008	9	.	.	.
cord-015021-pol2qm74	9009	1	The	the	DT
cord-015021-pol2qm74	9009	2	total	total	JJ
cord-015021-pol2qm74	9009	3	rate	rate	NN
cord-015021-pol2qm74	9009	4	of	of	IN
cord-015021-pol2qm74	9009	5	graft	graft	NN
cord-015021-pol2qm74	9009	6	infection	infection	NN
cord-015021-pol2qm74	9009	7	was	be	VBD
cord-015021-pol2qm74	9009	8	100	100	CD
cord-015021-pol2qm74	9009	9	%	%	NN
cord-015021-pol2qm74	9009	10	under	under	IN
cord-015021-pol2qm74	9009	11	short	short	JJ
cord-015021-pol2qm74	9009	12	term	term	NN
cord-015021-pol2qm74	9009	13	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	9009	14	and	and	CC
cord-015021-pol2qm74	9009	15	was	be	VBD
cord-015021-pol2qm74	9009	16	independent	independent	JJ
cord-015021-pol2qm74	9009	17	from	from	IN
cord-015021-pol2qm74	9009	18	preoperative	preoperative	JJ
cord-015021-pol2qm74	9009	19	HBV	HBV	NNP
cord-015021-pol2qm74	9009	20	DNA	dna	NN
cord-015021-pol2qm74	9009	21	status	status	NN
cord-015021-pol2qm74	9009	22	,	,	,
cord-015021-pol2qm74	9009	23	Under	under	IN
cord-015021-pol2qm74	9009	24	long	long	JJ
cord-015021-pol2qm74	9009	25	term	term	NN
cord-015021-pol2qm74	9009	26	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	9009	27	graft	graft	NN
cord-015021-pol2qm74	9009	28	infection	infection	NN
cord-015021-pol2qm74	9009	29	occurad	occurad	NN
cord-015021-pol2qm74	9009	30	in	in	IN
cord-015021-pol2qm74	9009	31	28	28	CD
cord-015021-pol2qm74	9009	32	%	%	NN
cord-015021-pol2qm74	9009	33	in	in	IN
cord-015021-pol2qm74	9009	34	pat	pat	NNP
cord-015021-pol2qm74	9009	35	,	,	,
cord-015021-pol2qm74	9009	36	negative	negative	JJ
cord-015021-pol2qm74	9009	37	for	for	IN
cord-015021-pol2qm74	9009	38	HBV	HBV	NNP
cord-015021-pol2qm74	9009	39	DNA	DNA	NNP
cord-015021-pol2qm74	9009	40	.	.	.
cord-015021-pol2qm74	9010	1	In	in	IN
cord-015021-pol2qm74	9010	2	HBV	HBV	NNP
cord-015021-pol2qm74	9010	3	DNA	DNA	NNP
cord-015021-pol2qm74	9010	4	positive	positive	JJ
cord-015021-pol2qm74	9010	5	pat	pat	NN
cord-015021-pol2qm74	9010	6	.	.	.
cord-015021-pol2qm74	9010	7	infection	infection	NN
cord-015021-pol2qm74	9010	8	rate	rate	NN
cord-015021-pol2qm74	9010	9	was	be	VBD
cord-015021-pol2qm74	9010	10	56	56	CD
cord-015021-pol2qm74	9010	11	%	%	NN
cord-015021-pol2qm74	9010	12	,	,	,
cord-015021-pol2qm74	9010	13	the	the	DT
cord-015021-pol2qm74	9010	14	total	total	JJ
cord-015021-pol2qm74	9010	15	rate	rate	NN
cord-015021-pol2qm74	9010	16	of	of	IN
cord-015021-pol2qm74	9010	17	reinfection	reinfection	NN
cord-015021-pol2qm74	9010	18	for	for	IN
cord-015021-pol2qm74	9010	19	all	all	DT
cord-015021-pol2qm74	9010	20	pat	pat	NN
cord-015021-pol2qm74	9010	21	.	.	.
cord-015021-pol2qm74	9011	1	with	with	IN
cord-015021-pol2qm74	9011	2	long	long	JJ
cord-015021-pol2qm74	9011	3	term	term	NN
cord-015021-pol2qm74	9011	4	prophylaxis	prophylaxis	NN
cord-015021-pol2qm74	9011	5	was	be	VBD
cord-015021-pol2qm74	9011	6	36%The	36%the	CD
cord-015021-pol2qm74	9011	7	results	result	NNS
cord-015021-pol2qm74	9011	8	of	of	IN
cord-015021-pol2qm74	9011	9	liver	liver	NN
cord-015021-pol2qm74	9011	10	transplantation	transplantation	NN
cord-015021-pol2qm74	9011	11	in	in	IN
cord-015021-pol2qm74	9011	12	HBsAg	HBsAg	NNP
cord-015021-pol2qm74	9011	13	positive	positive	JJ
cord-015021-pol2qm74	9011	14	pat	pat	NN
cord-015021-pol2qm74	9011	15	.	.	.
cord-015021-pol2qm74	9012	1	are	be	VBP
cord-015021-pol2qm74	9012	2	comparable	comparable	JJ
cord-015021-pol2qm74	9012	3	to	to	IN
cord-015021-pol2qm74	9012	4	other	other	JJ
cord-015021-pol2qm74	9012	5	indications	indication	NNS
cord-015021-pol2qm74	9012	6	,	,	,
cord-015021-pol2qm74	9012	7	Graft	graft	NN
cord-015021-pol2qm74	9012	8	infection	infection	NN
cord-015021-pol2qm74	9012	9	with	with	IN
cord-015021-pol2qm74	9012	10	hepatitis	hepatitis	NN
cord-015021-pol2qm74	9012	11	B	B	NNP
cord-015021-pol2qm74	9012	12	virus	virus	NN
cord-015021-pol2qm74	9012	13	ist	ist	NNP
cord-015021-pol2qm74	9012	14	the	the	DT
cord-015021-pol2qm74	9012	15	major	major	JJ
cord-015021-pol2qm74	9012	16	risk	risk	NN
cord-015021-pol2qm74	9012	17	factor	factor	NN
cord-015021-pol2qm74	9012	18	for	for	IN
cord-015021-pol2qm74	9012	19	these	these	DT
cord-015021-pol2qm74	9012	20	patients	patient	NNS
cord-015021-pol2qm74	9012	21	.	.	.
cord-015021-pol2qm74	9013	1	Under	under	IN
cord-015021-pol2qm74	9013	2	long	long	JJ
cord-015021-pol2qm74	9013	3	term	term	NN
cord-015021-pol2qm74	9013	4	therapy	therapy	NN
cord-015021-pol2qm74	9013	5	with	with	IN
cord-015021-pol2qm74	9013	6	HIG	HIG	NNP
cord-015021-pol2qm74	9013	7	the	the	DT
cord-015021-pol2qm74	9013	8	rate	rate	NN
cord-015021-pol2qm74	9013	9	of	of	IN
cord-015021-pol2qm74	9013	10	graft	graft	NN
cord-015021-pol2qm74	9013	11	infection	infection	NN
cord-015021-pol2qm74	9013	12	can	can	MD
cord-015021-pol2qm74	9013	13	be	be	VB
cord-015021-pol2qm74	9013	14	significantly	significantly	RB
cord-015021-pol2qm74	9013	15	reduced	reduce	VBN
cord-015021-pol2qm74	9013	16	.	.	.
cord-015021-pol2qm74	9014	1	THE	the	DT
cord-015021-pol2qm74	9014	2	CRUCIAL	CRUCIAL	NNP
cord-015021-pol2qm74	9014	3	CELLULAR	cellular	NN
cord-015021-pol2qm74	9014	4	ELEMENT	element	NN
cord-015021-pol2qm74	9014	5	FOR	for	IN
cord-015021-pol2qm74	9014	6	MODS	MODS	NNP
cord-015021-pol2qm74	9014	7	-	-	HYPH
cord-015021-pol2qm74	9014	8	MOF	MOF	NNP
cord-015021-pol2qm74	9014	9	:	:	:
cord-015021-pol2qm74	9015	1	MONOCYI'F_./M	MONOCYI'F_./M	NNP
cord-015021-pol2qm74	9015	2	ACROPHAOE	ACROPHAOE	NNP
cord-015021-pol2qm74	9015	3	Ronald	Ronald	NNP
cord-015021-pol2qm74	9015	4	V.	V.	NNP
cord-015021-pol2qm74	9015	5	Meier	Meier	NNP
cord-015021-pol2qm74	9015	6	,	,	,
cord-015021-pol2qm74	9015	7	M	M	NNP
cord-015021-pol2qm74	9015	8	,	,	,
cord-015021-pol2qm74	9015	9	D.	D.	NNP
cord-015021-pol2qm74	9015	10	,	,	,
cord-015021-pol2qm74	9015	11	F.A	F.A	NNP
cord-015021-pol2qm74	9015	12	,	,	,
cord-015021-pol2qm74	9015	13	C	C	NNP
cord-015021-pol2qm74	9015	14	,	,	,
cord-015021-pol2qm74	9015	15	S.	S.	NNP
cord-015021-pol2qm74	9016	1	The	the	DT
cord-015021-pol2qm74	9016	2	severely	severely	RB
cord-015021-pol2qm74	9016	3	:	:	:
cord-015021-pol2qm74	9016	4	injured	injure	VBN
cord-015021-pol2qm74	9016	5	or	or	CC
cord-015021-pol2qm74	9016	6	crldcally	crldcally	RB
cord-015021-pol2qm74	9016	7	ill	ill	JJ
cord-015021-pol2qm74	9016	8	surgical	surgical	JJ
cord-015021-pol2qm74	9016	9	patient	patient	NN
cord-015021-pol2qm74	9016	10	is	be	VBZ
cord-015021-pol2qm74	9016	11	at	at	IN
cord-015021-pol2qm74	9016	12	high	high	JJ
cord-015021-pol2qm74	9016	13	risk	risk	NN
cord-015021-pol2qm74	9016	14	for	for	IN
cord-015021-pol2qm74	9016	15	immune	immune	JJ
cord-015021-pol2qm74	9016	16	dysfunction	dysfunction	NN
cord-015021-pol2qm74	9016	17	.	.	.
cord-015021-pol2qm74	9017	1	A	a	DT
cord-015021-pol2qm74	9017	2	major	major	JJ
cord-015021-pol2qm74	9017	3	consequence	consequence	NN
cord-015021-pol2qm74	9017	4	of	of	IN
cord-015021-pol2qm74	9017	5	this	this	DT
cord-015021-pol2qm74	9017	6	immune	immune	JJ
cord-015021-pol2qm74	9017	7	dysfunction	dysfunction	NN
cord-015021-pol2qm74	9017	8	is	be	VBZ
cord-015021-pol2qm74	9017	9	multiple	multiple	JJ
cord-015021-pol2qm74	9017	10	organ	organ	NN
cord-015021-pol2qm74	9017	11	dysfunction	dysfunction	NN
cord-015021-pol2qm74	9017	12	and	and	CC
cord-015021-pol2qm74	9017	13	failure	failure	NN
cord-015021-pol2qm74	9017	14	leading	lead	VBG
cord-015021-pol2qm74	9017	15	to	to	IN
cord-015021-pol2qm74	9017	16	death	death	NN
cord-015021-pol2qm74	9017	17	,	,	,
cord-015021-pol2qm74	9017	18	The	the	DT
cord-015021-pol2qm74	9017	19	underlying	underlying	JJ
cord-015021-pol2qm74	9017	20	etiology	etiology	NN
cord-015021-pol2qm74	9017	21	is	be	VBZ
cord-015021-pol2qm74	9017	22	now	now	RB
cord-015021-pol2qm74	9017	23	recognized	recognize	VBN
cord-015021-pol2qm74	9017	24	to	to	TO
cord-015021-pol2qm74	9017	25	be	be	VB
cord-015021-pol2qm74	9017	26	an	an	DT
cord-015021-pol2qm74	9017	27	uncontrolled	uncontrolled	JJ
cord-015021-pol2qm74	9017	28	,	,	,
cord-015021-pol2qm74	9017	29	unfocused	unfocused	JJ
cord-015021-pol2qm74	9017	30	,	,	,
cord-015021-pol2qm74	9017	31	disseminated	disseminate	VBN
cord-015021-pol2qm74	9017	32	activation	activation	NN
cord-015021-pol2qm74	9017	33	of	of	IN
cord-015021-pol2qm74	9017	34	the	the	DT
cord-015021-pol2qm74	9017	35	host	host	NN
cord-015021-pol2qm74	9017	36	normally	normally	RB
cord-015021-pol2qm74	9017	37	protective	protective	VBP
cord-015021-pol2qm74	9017	38	inflammatory	inflammatory	NN
cord-015021-pol2qm74	9017	39	.	.	.
cord-015021-pol2qm74	9018	1	,	,	,
cord-015021-pol2qm74	9018	2	,	,	,
cord-015021-pol2qm74	9018	3	cascades	cascade	NNS
cord-015021-pol2qm74	9018	4	..	..	.
cord-015021-pol2qm74	9019	1	The	the	DT
cord-015021-pol2qm74	9019	2	resultant	resultant	JJ
cord-015021-pol2qm74	9019	3	"	"	``
cord-015021-pol2qm74	9019	4	mahgnant	mahgnant	JJ
cord-015021-pol2qm74	9019	5	'	'	''
cord-015021-pol2qm74	9019	6	systemic	systemic	JJ
cord-015021-pol2qm74	9019	7	"	"	''
cord-015021-pol2qm74	9019	8	inflan'a'natlon	inflan'a'natlon	NNP
cord-015021-pol2qm74	9019	9	produces	produce	VBZ
cord-015021-pol2qm74	9019	10	d	d	NNP
cord-015021-pol2qm74	9019	11	~	~	NFP
cord-015021-pol2qm74	9019	12	ffuso	ffuso	NNP
cord-015021-pol2qm74	9019	13	multiple	multiple	JJ
cord-015021-pol2qm74	9019	14	organ	organ	NN
cord-015021-pol2qm74	9019	15	bystander	bystander	NN
cord-015021-pol2qm74	9019	16	injury	injury	NN
cord-015021-pol2qm74	9019	17	!	!	.
cord-015021-pol2qm74	9020	1	eading	eade	VBG
cord-015021-pol2qm74	9020	2	to	to	IN
cord-015021-pol2qm74	9020	3	progressive	progressive	JJ
cord-015021-pol2qm74	9020	4	organ	organ	NN
cord-015021-pol2qm74	9020	5	dysfunction	dysfunction	NN
cord-015021-pol2qm74	9020	6	and	and	CC
cord-015021-pol2qm74	9020	7	failure	failure	NN
cord-015021-pol2qm74	9020	8	.	.	.
cord-015021-pol2qm74	9021	1	Systemic	systemic	JJ
cord-015021-pol2qm74	9021	2	malignant	malignant	JJ
cord-015021-pol2qm74	9021	3	inflammation	inflammation	NN
cord-015021-pol2qm74	9021	4	involves	involve	VBZ
cord-015021-pol2qm74	9021	5	diffuse	diffuse	JJ
cord-015021-pol2qm74	9021	6	actlvatton	actlvatton	NNS
cord-015021-pol2qm74	9021	7	of	of	IN
cord-015021-pol2qm74	9021	8	all	all	DT
cord-015021-pol2qm74	9021	9	components	component	NNS
cord-015021-pol2qm74	9021	10	of	of	IN
cord-015021-pol2qm74	9021	11	the	the	DT
cord-015021-pol2qm74	9021	12	humoral	humoral	JJ
cord-015021-pol2qm74	9021	13	and	and	CC
cord-015021-pol2qm74	9021	14	cellular	cellular	JJ
cord-015021-pol2qm74	9021	15	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	9021	16	host	host	NN
cord-015021-pol2qm74	9021	17	response	response	NN
cord-015021-pol2qm74	9021	18	.	.	.
cord-015021-pol2qm74	9022	1	Of	of	IN
cord-015021-pol2qm74	9022	2	these	these	DT
cord-015021-pol2qm74	9022	3	various	various	JJ
cord-015021-pol2qm74	9022	4	components	component	NNS
cord-015021-pol2qm74	9022	5	,	,	,
cord-015021-pol2qm74	9022	6	the	the	DT
cord-015021-pol2qm74	9022	7	macropha	macropha	NN
cord-015021-pol2qm74	9022	8	~	~	NFP
cord-015021-pol2qm74	9022	9	e	e	NNP
cord-015021-pol2qm74	9022	10	is	be	VBZ
cord-015021-pol2qm74	9022	11	the	the	DT
cord-015021-pol2qm74	9022	12	crucial	crucial	JJ
cord-015021-pol2qm74	9022	13	central	central	JJ
cord-015021-pol2qm74	9022	14	cellular	cellular	JJ
cord-015021-pol2qm74	9022	15	element	element	NN
cord-015021-pol2qm74	9022	16	.	.	.
cord-015021-pol2qm74	9023	1	The	the	DT
cord-015021-pol2qm74	9023	2	tissue	tissue	NN
cord-015021-pol2qm74	9023	3	fixed	fix	VBN
cord-015021-pol2qm74	9023	4	macrophage	macrophage	NN
cord-015021-pol2qm74	9023	5	Is	be	VBZ
cord-015021-pol2qm74	9023	6	ideally	ideally	RB
cord-015021-pol2qm74	9023	7	located	locate	VBN
cord-015021-pol2qm74	9023	8	diffusely	diffusely	RB
cord-015021-pol2qm74	9023	9	throughout	throughout	IN
cord-015021-pol2qm74	9023	10	the	the	DT
cord-015021-pol2qm74	9023	11	various	various	JJ
cord-015021-pol2qm74	9023	12	organs	organ	NNS
cord-015021-pol2qm74	9023	13	injured	injure	VBN
cord-015021-pol2qm74	9023	14	to	to	TO
cord-015021-pol2qm74	9023	15	orchestrate	orchestrate	VB
cord-015021-pol2qm74	9023	16	the	the	DT
cord-015021-pol2qm74	9023	17	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	9023	18	process	process	NN
cord-015021-pol2qm74	9023	19	.	.	.
cord-015021-pol2qm74	9024	1	The	the	DT
cord-015021-pol2qm74	9024	2	macrophage	macrophage	NN
cord-015021-pol2qm74	9024	3	is	be	VBZ
cord-015021-pol2qm74	9024	4	long	long	RB
cord-015021-pol2qm74	9024	5	-	-	HYPH
cord-015021-pol2qm74	9024	6	lived	live	VBN
cord-015021-pol2qm74	9024	7	and	and	CC
cord-015021-pol2qm74	9024	8	highly	highly	RB
cord-015021-pol2qm74	9024	9	metabolic	metabolic	JJ
cord-015021-pol2qm74	9024	10	,	,	,
cord-015021-pol2qm74	9024	11	The	the	DT
cord-015021-pol2qm74	9024	12	macrophage	macrophage	NN
cord-015021-pol2qm74	9024	13	regulates	regulate	VBZ
cord-015021-pol2qm74	9024	14	both	both	CC
cord-015021-pol2qm74	9024	15	the	the	DT
cord-015021-pol2qm74	9024	16	extent	extent	NN
cord-015021-pol2qm74	9024	17	and	and	CC
cord-015021-pol2qm74	9024	18	the	the	DT
cord-015021-pol2qm74	9024	19	dissemination	dissemination	NN
cord-015021-pol2qm74	9024	20	of	of	IN
cord-015021-pol2qm74	9024	21	the	the	DT
cord-015021-pol2qm74	9024	22	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	9024	23	processes	process	NNS
cord-015021-pol2qm74	9024	24	.	.	.
cord-015021-pol2qm74	9025	1	The	the	DT
cord-015021-pol2qm74	9025	2	macrophage	macrophage	NN
cord-015021-pol2qm74	9025	3	is	be	VBZ
cord-015021-pol2qm74	9025	4	an	an	DT
cord-015021-pol2qm74	9025	5	exu'emely	exu'emely	RB
cord-015021-pol2qm74	9025	6	active	active	JJ
cord-015021-pol2qm74	9025	7	c¢11	c¢11	NNP
cord-015021-pol2qm74	9025	8	capable	capable	JJ
cord-015021-pol2qm74	9025	9	of	of	IN
cord-015021-pol2qm74	9025	10	producing	produce	VBG
cord-015021-pol2qm74	9025	11	and	and	CC
cord-015021-pol2qm74	9025	12	releasing	release	VBG
cord-015021-pol2qm74	9025	13	not	not	RB
cord-015021-pol2qm74	9025	14	only	only	RB
cord-015021-pol2qm74	9025	15	directly	directly	RB
cord-015021-pol2qm74	9025	16	eytotoxlc	eytotoxlc	JJ
cord-015021-pol2qm74	9025	17	agents	agent	NNS
cord-015021-pol2qm74	9025	18	,	,	,
cord-015021-pol2qm74	9025	19	s	s	NNP
cord-015021-pol2qm74	9025	20	irnil~	irnil~	NNP
cord-015021-pol2qm74	9025	21	,	,	,
cord-015021-pol2qm74	9025	22	to	to	IN
cord-015021-pol2qm74	9025	23	the	the	DT
cord-015021-pol2qm74	9025	24	neutrophil	neutrophil	NN
cord-015021-pol2qm74	9025	25	,	,	,
cord-015021-pol2qm74	9025	26	including	include	VBG
cord-015021-pol2qm74	9025	27	oxidants	oxidant	NNS
cord-015021-pol2qm74	9025	28	and	and	CC
cord-015021-pol2qm74	9025	29	numerous	numerous	JJ
cord-015021-pol2qm74	9025	30	proteases	protease	NNS
cord-015021-pol2qm74	9025	31	out	out	RB
cord-015021-pol2qm74	9025	32	also	also	RB
cord-015021-pol2qm74	9025	33	the	the	DT
cord-015021-pol2qm74	9025	34	multitude	multitude	NN
cord-015021-pol2qm74	9025	35	of	of	IN
cord-015021-pol2qm74	9025	36	other	other	JJ
cord-015021-pol2qm74	9025	37	cytokines	cytokine	NNS
cord-015021-pol2qm74	9025	38	and	and	CC
cord-015021-pol2qm74	9025	39	initiators	initiator	NNS
cord-015021-pol2qm74	9025	40	of	of	IN
cord-015021-pol2qm74	9025	41	the	the	DT
cord-015021-pol2qm74	9025	42	interacting	interact	VBG
cord-015021-pol2qm74	9025	43	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	9025	44	cascades	cascade	NNS
cord-015021-pol2qm74	9025	45	.	.	.
cord-015021-pol2qm74	9026	1	The	the	DT
cord-015021-pol2qm74	9026	2	macrophage	macrophage	NN
cord-015021-pol2qm74	9026	3	is	be	VBZ
cord-015021-pol2qm74	9026	4	the	the	DT
cord-015021-pol2qm74	9026	5	central	central	JJ
cord-015021-pol2qm74	9026	6	source	source	NN
cord-015021-pol2qm74	9026	7	for	for	IN
cord-015021-pol2qm74	9026	8	ehemotactic	ehemotactic	JJ
cord-015021-pol2qm74	9026	9	agents	agent	NNS
cord-015021-pol2qm74	9026	10	(	(	-LRB-
cord-015021-pol2qm74	9026	11	IL-8	IL-8	NNP
cord-015021-pol2qm74	9026	12	,	,	,
cord-015021-pol2qm74	9026	13	LTB4	LTB4	NNP
cord-015021-pol2qm74	9026	14	,	,	,
cord-015021-pol2qm74	9026	15	C5a	C5a	NNP
cord-015021-pol2qm74	9026	16	)	)	-RRB-
cord-015021-pol2qm74	9026	17	for	for	IN
cord-015021-pol2qm74	9026	18	neutrophils	neutrophil	NNS
cord-015021-pol2qm74	9026	19	and	and	CC
cord-015021-pol2qm74	9026	20	other	other	JJ
cord-015021-pol2qm74	9026	21	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	9026	22	cells	cell	NNS
cord-015021-pol2qm74	9026	23	,	,	,
cord-015021-pol2qm74	9026	24	production	production	NN
cord-015021-pol2qm74	9026	25	of	of	IN
cord-015021-pol2qm74	9026	26	vasoaetive	vasoaetive	NNP
cord-015021-pol2qm74	9026	27	arachidonie	arachidonie	NNP
cord-015021-pol2qm74	9026	28	acid	acid	NN
cord-015021-pol2qm74	9026	29	metabolites	metabolite	NNS
cord-015021-pol2qm74	9026	30	(	(	-LRB-
cord-015021-pol2qm74	9026	31	TX	TX	NNP
cord-015021-pol2qm74	9026	32	,	,	,
cord-015021-pol2qm74	9026	33	PGI2	PGI2	NNP
cord-015021-pol2qm74	9026	34	,	,	,
cord-015021-pol2qm74	9026	35	POE	POE	NNP
cord-015021-pol2qm74	9026	36	,	,	,
cord-015021-pol2qm74	9026	37	LT	LT	NNP
cord-015021-pol2qm74	9026	38	's	's	POS
cord-015021-pol2qm74	9026	39	)	)	-RRB-
cord-015021-pol2qm74	9026	40	,	,	,
cord-015021-pol2qm74	9026	41	complement	complement	VB
cord-015021-pol2qm74	9026	42	components	component	NNS
cord-015021-pol2qm74	9026	43	(	(	-LRB-
cord-015021-pol2qm74	9026	44	C3a	C3a	NNP
cord-015021-pol2qm74	9026	45	,	,	,
cord-015021-pol2qm74	9026	46	CSa	CSa	NNP
cord-015021-pol2qm74	9026	47	)	)	-RRB-
cord-015021-pol2qm74	9026	48	,	,	,
cord-015021-pol2qm74	9026	49	thrombotic	thrombotic	JJ
cord-015021-pol2qm74	9026	50	agents	agent	NNS
cord-015021-pol2qm74	9026	51	(	(	-LRB-
cord-015021-pol2qm74	9026	52	PCA	PCA	NNP
cord-015021-pol2qm74	9026	53	,	,	,
cord-015021-pol2qm74	9026	54	TX	TX	NNP
cord-015021-pol2qm74	9026	55	)	)	-RRB-
cord-015021-pol2qm74	9026	56	,	,	,
cord-015021-pol2qm74	9026	57	metabolic	metabolic	JJ
cord-015021-pol2qm74	9026	58	and	and	CC
cord-015021-pol2qm74	9026	59	physiologic	physiologic	JJ
cord-015021-pol2qm74	9026	60	modulators	modulator	NNS
cord-015021-pol2qm74	9026	61	(	(	-LRB-
cord-015021-pol2qm74	9026	62	IL,1	il,1	RB
cord-015021-pol2qm74	9026	63	,	,	,
cord-015021-pol2qm74	9026	64	IL-6	IL-6	NNP
cord-015021-pol2qm74	9026	65	or	or	CC
cord-015021-pol2qm74	9026	66	TNF	TNF	NNP
cord-015021-pol2qm74	9026	67	)	)	-RRB-
cord-015021-pol2qm74	9026	68	,	,	,
cord-015021-pol2qm74	9026	69	and	and	CC
cord-015021-pol2qm74	9026	70	immunosuppressivc	immunosuppressivc	NNP
cord-015021-pol2qm74	9026	71	agents	agent	NNS
cord-015021-pol2qm74	9026	72	(	(	-LRB-
cord-015021-pol2qm74	9026	73	POE2	POE2	NNP
cord-015021-pol2qm74	9026	74	,	,	,
cord-015021-pol2qm74	9026	75	IL-10	IL-10	NNP
cord-015021-pol2qm74	9026	76	)	)	-RRB-
cord-015021-pol2qm74	9026	77	.	.	.
cord-015021-pol2qm74	9027	1	These	these	DT
cord-015021-pol2qm74	9027	2	products	product	NNS
cord-015021-pol2qm74	9027	3	of	of	IN
cord-015021-pol2qm74	9027	4	the	the	DT
cord-015021-pol2qm74	9027	5	macrophage	macrophage	NN
cord-015021-pol2qm74	9027	6	are	be	VBP
cord-015021-pol2qm74	9027	7	highly	highly	RB
cord-015021-pol2qm74	9027	8	effective	effective	JJ
cord-015021-pol2qm74	9027	9	in	in	IN
cord-015021-pol2qm74	9027	10	enhancing	enhance	VBG
cord-015021-pol2qm74	9027	11	and	and	CC
cord-015021-pol2qm74	9027	12	augmenting	augment	VBG
cord-015021-pol2qm74	9027	13	the	the	DT
cord-015021-pol2qm74	9027	14	inflammatory	inflammatory	JJ
cord-015021-pol2qm74	9027	15	response	response	NN
cord-015021-pol2qm74	9027	16	.	.	.
cord-015021-pol2qm74	9028	1	Disseminated	disseminate	VBN
cord-015021-pol2qm74	9028	2	activation	activation	NN
cord-015021-pol2qm74	9028	3	otthe	otthe	DT
cord-015021-pol2qm74	9028	4	macrophage	macrophage	NN
cord-015021-pol2qm74	9028	5	Is	be	VBZ
cord-015021-pol2qm74	9028	6	critical	critical	JJ
cord-015021-pol2qm74	9028	7	to	to	IN
cord-015021-pol2qm74	9028	8	the	the	DT
cord-015021-pol2qm74	9028	9	induction	induction	NN
cord-015021-pol2qm74	9028	10	of	of	IN
cord-015021-pol2qm74	9028	11	the	the	DT
cord-015021-pol2qm74	9028	12	long	long	JJ
cord-015021-pol2qm74	9028	13	-	-	HYPH
cord-015021-pol2qm74	9028	14	term	term	NN
cord-015021-pol2qm74	9028	15	diffuse	diffuse	JJ
cord-015021-pol2qm74	9028	16	activation	activation	NN
cord-015021-pol2qm74	9028	17	of	of	IN
cord-015021-pol2qm74	9028	18	inflammation	inflammation	NN
cord-015021-pol2qm74	9028	19	necessary	necessary	JJ
cord-015021-pol2qm74	9028	20	to	to	TO
cord-015021-pol2qm74	9028	21	induce	induce	VB
cord-015021-pol2qm74	9028	22	multiple	multiple	JJ
cord-015021-pol2qm74	9028	23	organ	organ	NN
cord-015021-pol2qm74	9028	24	injury	injury	NN
cord-015021-pol2qm74	9028	25	and	and	CC
cord-015021-pol2qm74	9028	26	failure	failure	NN
cord-015021-pol2qm74	9028	27	.	.	.
cord-015021-pol2qm74	9029	1	Our	-PRON-	PRP$
cord-015021-pol2qm74	9029	2	ability	ability	NN
cord-015021-pol2qm74	9029	3	to	to	TO
cord-015021-pol2qm74	9029	4	elucidate	elucidate	VB
cord-015021-pol2qm74	9029	5	the	the	DT
cord-015021-pol2qm74	9029	6	molecular	molecular	JJ
cord-015021-pol2qm74	9029	7	mechanisms	mechanism	NNS
cord-015021-pol2qm74	9029	8	that	that	WDT
cord-015021-pol2qm74	9029	9	control	control	VBP
cord-015021-pol2qm74	9029	10	the	the	DT
cord-015021-pol2qm74	9029	11	macrophage	macrophage	NN
cord-015021-pol2qm74	9029	12	will	will	MD
cord-015021-pol2qm74	9029	13	lead	lead	VB
cord-015021-pol2qm74	9029	14	to	to	IN
cord-015021-pol2qm74	9029	15	our	-PRON-	PRP$
cord-015021-pol2qm74	9029	16	ability	ability	NN
cord-015021-pol2qm74	9029	17	to	to	TO
cord-015021-pol2qm74	9029	18	conu'ol	conu'ol	VB
cord-015021-pol2qm74	9029	19	the	the	DT
cord-015021-pol2qm74	9029	20	maerophage	maerophage	NN
cord-015021-pol2qm74	9029	21	response	response	NN
cord-015021-pol2qm74	9029	22	and	and	CC
cord-015021-pol2qm74	9029	23	prevent	prevent	VB
cord-015021-pol2qm74	9029	24	MODS	MODS	NNP
cord-015021-pol2qm74	9029	25	-	-	HYPH
cord-015021-pol2qm74	9029	26	MOF.Flarborview	MOF.Flarborview	NNP
cord-015021-pol2qm74	9029	27	Medical	Medical	NNP
cord-015021-pol2qm74	9029	28	Center	Center	NNP
cord-015021-pol2qm74	9029	29	,	,	,
cord-015021-pol2qm74	9029	30	325	325	CD
cord-015021-pol2qm74	9029	31	-	-	HYPH
cord-015021-pol2qm74	9029	32	9th	9th	NN
cord-015021-pol2qm74	9029	33	Ave	Ave	NNP
cord-015021-pol2qm74	9029	34	ZA-16	ZA-16	NNP
cord-015021-pol2qm74	9029	35	,	,	,
cord-015021-pol2qm74	9029	36	Seattle	Seattle	NNP
cord-015021-pol2qm74	9029	37	,	,	,
cord-015021-pol2qm74	9029	38	WA	WA	NNP
cord-015021-pol2qm74	9029	39	98104	98104	CD
cord-015021-pol2qm74	9029	40	USA	USA	NNP