id	sid	tid	token	lemma	pos
cord-015910-d9gxew91	1	1	key	key	JJ
cord-015910-d9gxew91	1	2	:	:	:
cord-015910-d9gxew91	1	3	cord-015910-d9gxew91	cord-015910-d9gxew91	ADD
cord-015910-d9gxew91	2	1	authors	author	NNS
cord-015910-d9gxew91	2	2	:	:	:
cord-015910-d9gxew91	2	3	Grimble	Grimble	NNP
cord-015910-d9gxew91	2	4	,	,	,
cord-015910-d9gxew91	2	5	Robert	Robert	NNP
cord-015910-d9gxew91	2	6	F.	F.	NNP
cord-015910-d9gxew91	2	7	title	title	NN
cord-015910-d9gxew91	2	8	:	:	:
cord-015910-d9gxew91	2	9	The	the	DT
cord-015910-d9gxew91	2	10	Interaction	Interaction	NNP
cord-015910-d9gxew91	2	11	Between	between	IN
cord-015910-d9gxew91	2	12	Nutrition	Nutrition	NNP
cord-015910-d9gxew91	2	13	and	and	CC
cord-015910-d9gxew91	2	14	Inflammatory	Inflammatory	NNP
cord-015910-d9gxew91	2	15	Stress	Stress	NNP
cord-015910-d9gxew91	2	16	Throughout	throughout	IN
cord-015910-d9gxew91	2	17	the	the	DT
cord-015910-d9gxew91	2	18	Life	Life	NNP
cord-015910-d9gxew91	2	19	Cycle	Cycle	NNP
cord-015910-d9gxew91	2	20	date	date	NN
cord-015910-d9gxew91	2	21	:	:	:
cord-015910-d9gxew91	3	1	2005	2005	CD
cord-015910-d9gxew91	3	2	journal	journal	NN
cord-015910-d9gxew91	3	3	:	:	:
cord-015910-d9gxew91	3	4	Nutrients	nutrient	NNS
cord-015910-d9gxew91	3	5	,	,	,
cord-015910-d9gxew91	3	6	Stress	stress	NN
cord-015910-d9gxew91	3	7	,	,	,
cord-015910-d9gxew91	3	8	and	and	CC
cord-015910-d9gxew91	3	9	Medical	Medical	NNP
cord-015910-d9gxew91	3	10	Disorders	Disorders	NNPS
cord-015910-d9gxew91	4	1	DOI	DOI	NNP
cord-015910-d9gxew91	4	2	:	:	:
cord-015910-d9gxew91	4	3	10.1385/1	10.1385/1	CD
cord-015910-d9gxew91	4	4	-	-	HYPH
cord-015910-d9gxew91	4	5	59259	59259	CD
cord-015910-d9gxew91	4	6	-	-	HYPH
cord-015910-d9gxew91	4	7	952	952	CD
cord-015910-d9gxew91	4	8	-	-	HYPH
cord-015910-d9gxew91	4	9	4:387	4:387	CD
cord-015910-d9gxew91	4	10	sha	sha	NNP
cord-015910-d9gxew91	4	11	:	:	:
cord-015910-d9gxew91	4	12	985304a925f8e0907ac412e693ec3c95c8b65772	985304a925f8e0907ac412e693ec3c95c8b65772	CD
cord-015910-d9gxew91	4	13	doc_id	doc_id	CD
cord-015910-d9gxew91	4	14	:	:	:
cord-015910-d9gxew91	4	15	15910	15910	CD
cord-015910-d9gxew91	4	16	cord_uid	cord_uid	NNS
cord-015910-d9gxew91	4	17	:	:	:
cord-015910-d9gxew91	5	1	d9gxew91	d9gxew91	NNP
cord-015910-d9gxew91	6	1	The	the	DT
cord-015910-d9gxew91	6	2	human	human	JJ
cord-015910-d9gxew91	6	3	race	race	NN
cord-015910-d9gxew91	6	4	inhabits	inhabit	VBZ
cord-015910-d9gxew91	6	5	a	a	DT
cord-015910-d9gxew91	6	6	world	world	NN
cord-015910-d9gxew91	6	7	in	in	IN
cord-015910-d9gxew91	6	8	which	which	WDT
cord-015910-d9gxew91	6	9	it	-PRON-	PRP
cord-015910-d9gxew91	6	10	is	be	VBZ
cord-015910-d9gxew91	6	11	surrounded	surround	VBN
cord-015910-d9gxew91	6	12	by	by	IN
cord-015910-d9gxew91	6	13	a	a	DT
cord-015910-d9gxew91	6	14	myriad	myriad	NN
cord-015910-d9gxew91	6	15	of	of	IN
cord-015910-d9gxew91	6	16	different	different	JJ
cord-015910-d9gxew91	6	17	microorganisms	microorganism	NNS
cord-015910-d9gxew91	6	18	—	—	:
cord-015910-d9gxew91	6	19	yeasts	yeast	NNS
cord-015910-d9gxew91	6	20	,	,	,
cord-015910-d9gxew91	6	21	bacteria	bacteria	NNS
cord-015910-d9gxew91	6	22	,	,	,
cord-015910-d9gxew91	6	23	protozoa	protozoan	NNS
cord-015910-d9gxew91	6	24	,	,	,
cord-015910-d9gxew91	6	25	and	and	CC
cord-015910-d9gxew91	6	26	viruses	virus	NNS
cord-015910-d9gxew91	6	27	.	.	.
cord-015910-d9gxew91	7	1	Most	Most	JJS
cord-015910-d9gxew91	7	2	of	of	IN
cord-015910-d9gxew91	7	3	these	these	DT
cord-015910-d9gxew91	7	4	are	be	VBP
cord-015910-d9gxew91	7	5	benign	benign	JJ
cord-015910-d9gxew91	7	6	,	,	,
cord-015910-d9gxew91	7	7	and	and	CC
cord-015910-d9gxew91	7	8	some	some	DT
cord-015910-d9gxew91	7	9	,	,	,
cord-015910-d9gxew91	7	10	such	such	JJ
cord-015910-d9gxew91	7	11	as	as	IN
cord-015910-d9gxew91	7	12	the	the	DT
cord-015910-d9gxew91	7	13	normal	normal	JJ
cord-015910-d9gxew91	7	14	gut	gut	NN
cord-015910-d9gxew91	7	15	flora	flora	NNS
cord-015910-d9gxew91	7	16	,	,	,
cord-015910-d9gxew91	7	17	play	play	VB
cord-015910-d9gxew91	7	18	an	an	DT
cord-015910-d9gxew91	7	19	important	important	JJ
cord-015910-d9gxew91	7	20	part	part	NN
cord-015910-d9gxew91	7	21	in	in	IN
cord-015910-d9gxew91	7	22	promoting	promote	VBG
cord-015910-d9gxew91	7	23	health	health	NN
cord-015910-d9gxew91	7	24	via	via	IN
cord-015910-d9gxew91	7	25	the	the	DT
cord-015910-d9gxew91	7	26	synthesis	synthesis	NN
cord-015910-d9gxew91	7	27	of	of	IN
cord-015910-d9gxew91	7	28	vitamins	vitamin	NNS
cord-015910-d9gxew91	7	29	and	and	CC
cord-015910-d9gxew91	7	30	stimulation	stimulation	NN
cord-015910-d9gxew91	7	31	of	of	IN
cord-015910-d9gxew91	7	32	normal	normal	JJ
cord-015910-d9gxew91	7	33	function	function	NN
cord-015910-d9gxew91	7	34	of	of	IN
cord-015910-d9gxew91	7	35	gut	gut	NN
cord-015910-d9gxew91	7	36	epithelia	epithelium	NNS
cord-015910-d9gxew91	7	37	.	.	.
cord-015910-d9gxew91	8	1	Approximately	approximately	RB
cord-015910-d9gxew91	8	2	0.1	0.1	CD
cord-015910-d9gxew91	8	3	%	%	NN
cord-015910-d9gxew91	8	4	of	of	IN
cord-015910-d9gxew91	8	5	microbes	microbe	NNS
cord-015910-d9gxew91	8	6	in	in	IN
cord-015910-d9gxew91	8	7	our	-PRON-	PRP$
cord-015910-d9gxew91	8	8	environment	environment	NN
cord-015910-d9gxew91	8	9	have	have	VBP
cord-015910-d9gxew91	8	10	catastrophic	catastrophic	JJ
cord-015910-d9gxew91	8	11	effects	effect	NNS
cord-015910-d9gxew91	8	12	if	if	IN
cord-015910-d9gxew91	8	13	they	-PRON-	PRP
cord-015910-d9gxew91	8	14	penetrate	penetrate	VBP
cord-015910-d9gxew91	8	15	the	the	DT
cord-015910-d9gxew91	8	16	epithelial	epithelial	JJ
cord-015910-d9gxew91	8	17	surfaces	surface	NNS
cord-015910-d9gxew91	8	18	of	of	IN
cord-015910-d9gxew91	8	19	the	the	DT
cord-015910-d9gxew91	8	20	body	body	NN
cord-015910-d9gxew91	8	21	(	(	-LRB-
cord-015910-d9gxew91	8	22	Bryson	Bryson	NNP
cord-015910-d9gxew91	8	23	,	,	,
cord-015910-d9gxew91	8	24	2003	2003	CD
cord-015910-d9gxew91	8	25	)	)	-RRB-
cord-015910-d9gxew91	8	26	.	.	.
cord-015910-d9gxew91	9	1	History	history	NN
cord-015910-d9gxew91	9	2	reveals	reveal	VBZ
cord-015910-d9gxew91	9	3	many	many	JJ
cord-015910-d9gxew91	9	4	instances	instance	NNS
cord-015910-d9gxew91	9	5	in	in	IN
cord-015910-d9gxew91	9	6	which	which	WDT
cord-015910-d9gxew91	9	7	armies	army	NNS
cord-015910-d9gxew91	9	8	have	have	VBP
cord-015910-d9gxew91	9	9	been	be	VBN
cord-015910-d9gxew91	9	10	defeated	defeat	VBN
cord-015910-d9gxew91	9	11	and	and	CC
cord-015910-d9gxew91	9	12	civilizations	civilization	NNS
cord-015910-d9gxew91	9	13	have	have	VBP
cord-015910-d9gxew91	9	14	collapsed	collapse	VBN
cord-015910-d9gxew91	9	15	because	because	IN
cord-015910-d9gxew91	9	16	of	of	IN
cord-015910-d9gxew91	9	17	encounters	encounter	NNS
cord-015910-d9gxew91	9	18	between	between	IN
cord-015910-d9gxew91	9	19	humans	human	NNS
cord-015910-d9gxew91	9	20	and	and	CC
cord-015910-d9gxew91	9	21	such	such	JJ
cord-015910-d9gxew91	9	22	microorganisms	microorganism	NNS
cord-015910-d9gxew91	9	23	(	(	-LRB-
cord-015910-d9gxew91	9	24	Diamond	Diamond	NNP
cord-015910-d9gxew91	9	25	,	,	,
cord-015910-d9gxew91	9	26	1999	1999	CD
cord-015910-d9gxew91	9	27	)	)	-RRB-
cord-015910-d9gxew91	9	28	.	.	.
cord-015910-d9gxew91	10	1	The	the	DT
cord-015910-d9gxew91	10	2	human	human	JJ
cord-015910-d9gxew91	10	3	race	race	NN
cord-015910-d9gxew91	10	4	inhabits	inhabit	VBZ
cord-015910-d9gxew91	10	5	a	a	DT
cord-015910-d9gxew91	10	6	world	world	NN
cord-015910-d9gxew91	10	7	in	in	IN
cord-015910-d9gxew91	10	8	which	which	WDT
cord-015910-d9gxew91	10	9	it	-PRON-	PRP
cord-015910-d9gxew91	10	10	is	be	VBZ
cord-015910-d9gxew91	10	11	surrounded	surround	VBN
cord-015910-d9gxew91	10	12	by	by	IN
cord-015910-d9gxew91	10	13	a	a	DT
cord-015910-d9gxew91	10	14	myriad	myriad	NN
cord-015910-d9gxew91	10	15	of	of	IN
cord-015910-d9gxew91	10	16	different	different	JJ
cord-015910-d9gxew91	10	17	microorganisms	microorganism	NNS
cord-015910-d9gxew91	10	18	--	--	:
cord-015910-d9gxew91	10	19	yeasts	yeast	NNS
cord-015910-d9gxew91	10	20	,	,	,
cord-015910-d9gxew91	10	21	bacteria	bacteria	NNS
cord-015910-d9gxew91	10	22	,	,	,
cord-015910-d9gxew91	10	23	protozoa	protozoan	NNS
cord-015910-d9gxew91	10	24	,	,	,
cord-015910-d9gxew91	10	25	and	and	CC
cord-015910-d9gxew91	10	26	viruses	virus	NNS
cord-015910-d9gxew91	10	27	.	.	.
cord-015910-d9gxew91	11	1	Most	Most	JJS
cord-015910-d9gxew91	11	2	of	of	IN
cord-015910-d9gxew91	11	3	these	these	DT
cord-015910-d9gxew91	11	4	are	be	VBP
cord-015910-d9gxew91	11	5	benign	benign	JJ
cord-015910-d9gxew91	11	6	,	,	,
cord-015910-d9gxew91	11	7	and	and	CC
cord-015910-d9gxew91	11	8	some	some	DT
cord-015910-d9gxew91	11	9	,	,	,
cord-015910-d9gxew91	11	10	such	such	JJ
cord-015910-d9gxew91	11	11	as	as	IN
cord-015910-d9gxew91	11	12	the	the	DT
cord-015910-d9gxew91	11	13	normal	normal	JJ
cord-015910-d9gxew91	11	14	gut	gut	NN
cord-015910-d9gxew91	11	15	flora	flora	NNS
cord-015910-d9gxew91	11	16	,	,	,
cord-015910-d9gxew91	11	17	play	play	VB
cord-015910-d9gxew91	11	18	an	an	DT
cord-015910-d9gxew91	11	19	important	important	JJ
cord-015910-d9gxew91	11	20	part	part	NN
cord-015910-d9gxew91	11	21	in	in	IN
cord-015910-d9gxew91	11	22	promoting	promote	VBG
cord-015910-d9gxew91	11	23	health	health	NN
cord-015910-d9gxew91	11	24	via	via	IN
cord-015910-d9gxew91	11	25	the	the	DT
cord-015910-d9gxew91	11	26	synthesis	synthesis	NN
cord-015910-d9gxew91	11	27	of	of	IN
cord-015910-d9gxew91	11	28	vitamins	vitamin	NNS
cord-015910-d9gxew91	11	29	and	and	CC
cord-015910-d9gxew91	11	30	stimulation	stimulation	NN
cord-015910-d9gxew91	11	31	of	of	IN
cord-015910-d9gxew91	11	32	normal	normal	JJ
cord-015910-d9gxew91	11	33	function	function	NN
cord-015910-d9gxew91	11	34	of	of	IN
cord-015910-d9gxew91	11	35	gut	gut	NN
cord-015910-d9gxew91	11	36	epithelia	epithelium	NNS
cord-015910-d9gxew91	11	37	.	.	.
cord-015910-d9gxew91	12	1	Approximately	approximately	RB
cord-015910-d9gxew91	12	2	0.1	0.1	CD
cord-015910-d9gxew91	12	3	%	%	NN
cord-015910-d9gxew91	12	4	of	of	IN
cord-015910-d9gxew91	12	5	microbes	microbe	NNS
cord-015910-d9gxew91	12	6	in	in	IN
cord-015910-d9gxew91	12	7	our	-PRON-	PRP$
cord-015910-d9gxew91	12	8	environment	environment	NN
cord-015910-d9gxew91	12	9	have	have	VBP
cord-015910-d9gxew91	12	10	catastrophic	catastrophic	JJ
cord-015910-d9gxew91	12	11	effects	effect	NNS
cord-015910-d9gxew91	12	12	if	if	IN
cord-015910-d9gxew91	12	13	they	-PRON-	PRP
cord-015910-d9gxew91	12	14	penetrate	penetrate	VBP
cord-015910-d9gxew91	12	15	the	the	DT
cord-015910-d9gxew91	12	16	epithelial	epithelial	JJ
cord-015910-d9gxew91	12	17	surfaces	surface	NNS
cord-015910-d9gxew91	12	18	of	of	IN
cord-015910-d9gxew91	12	19	the	the	DT
cord-015910-d9gxew91	12	20	body	body	NN
cord-015910-d9gxew91	12	21	(	(	-LRB-
cord-015910-d9gxew91	12	22	Bryson	Bryson	NNP
cord-015910-d9gxew91	12	23	,	,	,
cord-015910-d9gxew91	12	24	2003	2003	CD
cord-015910-d9gxew91	12	25	)	)	-RRB-
cord-015910-d9gxew91	12	26	.	.	.
cord-015910-d9gxew91	13	1	History	history	NN
cord-015910-d9gxew91	13	2	reveals	reveal	VBZ
cord-015910-d9gxew91	13	3	many	many	JJ
cord-015910-d9gxew91	13	4	instances	instance	NNS
cord-015910-d9gxew91	13	5	in	in	IN
cord-015910-d9gxew91	13	6	which	which	WDT
cord-015910-d9gxew91	13	7	armies	army	NNS
cord-015910-d9gxew91	13	8	have	have	VBP
cord-015910-d9gxew91	13	9	been	be	VBN
cord-015910-d9gxew91	13	10	defeated	defeat	VBN
cord-015910-d9gxew91	13	11	and	and	CC
cord-015910-d9gxew91	13	12	civilizations	civilization	NNS
cord-015910-d9gxew91	13	13	have	have	VBP
cord-015910-d9gxew91	13	14	collapsed	collapse	VBN
cord-015910-d9gxew91	13	15	because	because	IN
cord-015910-d9gxew91	13	16	of	of	IN
cord-015910-d9gxew91	13	17	encounters	encounter	NNS
cord-015910-d9gxew91	13	18	between	between	IN
cord-015910-d9gxew91	13	19	humans	human	NNS
cord-015910-d9gxew91	13	20	and	and	CC
cord-015910-d9gxew91	13	21	such	such	JJ
cord-015910-d9gxew91	13	22	microorganisms	microorganism	NNS
cord-015910-d9gxew91	13	23	(	(	-LRB-
cord-015910-d9gxew91	13	24	Diamond	Diamond	NNP
cord-015910-d9gxew91	13	25	,	,	,
cord-015910-d9gxew91	13	26	1999	1999	CD
cord-015910-d9gxew91	13	27	)	)	-RRB-
cord-015910-d9gxew91	13	28	.	.	.
cord-015910-d9gxew91	14	1	Humans	human	NNS
cord-015910-d9gxew91	14	2	,	,	,
cord-015910-d9gxew91	14	3	like	like	IN
cord-015910-d9gxew91	14	4	all	all	DT
cord-015910-d9gxew91	14	5	mammals	mammal	NNS
cord-015910-d9gxew91	14	6	,	,	,
cord-015910-d9gxew91	14	7	have	have	VBP
cord-015910-d9gxew91	14	8	evolved	evolve	VBN
cord-015910-d9gxew91	14	9	with	with	IN
cord-015910-d9gxew91	14	10	a	a	DT
cord-015910-d9gxew91	14	11	complex	complex	JJ
cord-015910-d9gxew91	14	12	immune	immune	JJ
cord-015910-d9gxew91	14	13	system	system	NN
cord-015910-d9gxew91	14	14	,	,	,
cord-015910-d9gxew91	14	15	which	which	WDT
cord-015910-d9gxew91	14	16	is	be	VBZ
cord-015910-d9gxew91	14	17	present	present	JJ
cord-015910-d9gxew91	14	18	as	as	IN
cord-015910-d9gxew91	14	19	specialized	specialize	VBN
cord-015910-d9gxew91	14	20	organs	organ	NNS
cord-015910-d9gxew91	14	21	(	(	-LRB-
cord-015910-d9gxew91	14	22	spleen	spleen	NN
cord-015910-d9gxew91	14	23	,	,	,
cord-015910-d9gxew91	14	24	thymus	thymus	NN
cord-015910-d9gxew91	14	25	)	)	-RRB-
cord-015910-d9gxew91	14	26	or	or	CC
cord-015910-d9gxew91	14	27	cell	cell	NN
cord-015910-d9gxew91	14	28	types	type	NNS
cord-015910-d9gxew91	14	29	(	(	-LRB-
cord-015910-d9gxew91	14	30	lymphocytes	lymphocyte	NNS
cord-015910-d9gxew91	14	31	,	,	,
cord-015910-d9gxew91	14	32	macrophages	macrophage	NNS
cord-015910-d9gxew91	14	33	,	,	,
cord-015910-d9gxew91	14	34	and	and	CC
cord-015910-d9gxew91	14	35	mast	mast	NN
cord-015910-d9gxew91	14	36	cells	cell	NNS
cord-015910-d9gxew91	14	37	)	)	-RRB-
cord-015910-d9gxew91	14	38	throughout	throughout	IN
cord-015910-d9gxew91	14	39	the	the	DT
cord-015910-d9gxew91	14	40	body	body	NN
cord-015910-d9gxew91	14	41	.	.	.
cord-015910-d9gxew91	15	1	The	the	DT
cord-015910-d9gxew91	15	2	system	system	NN
cord-015910-d9gxew91	15	3	can	can	MD
cord-015910-d9gxew91	15	4	detect	detect	VB
cord-015910-d9gxew91	15	5	and	and	CC
cord-015910-d9gxew91	15	6	destroy	destroy	VB
cord-015910-d9gxew91	15	7	any	any	DT
cord-015910-d9gxew91	15	8	cell	cell	NN
cord-015910-d9gxew91	15	9	or	or	CC
cord-015910-d9gxew91	15	10	particle	particle	NN
cord-015910-d9gxew91	15	11	that	that	WDT
cord-015910-d9gxew91	15	12	is	be	VBZ
cord-015910-d9gxew91	15	13	not"self	not"self	PRP
cord-015910-d9gxew91	15	14	,	,	,
cord-015910-d9gxew91	15	15	"	"	''
cord-015910-d9gxew91	15	16	i.e.	i.e.	FW
cord-015910-d9gxew91	15	17	,	,	,
cord-015910-d9gxew91	15	18	a	a	DT
cord-015910-d9gxew91	15	19	normal	normal	JJ
cord-015910-d9gxew91	15	20	component	component	NN
cord-015910-d9gxew91	15	21	of	of	IN
cord-015910-d9gxew91	15	22	the	the	DT
cord-015910-d9gxew91	15	23	body	body	NN
cord-015910-d9gxew91	15	24	.	.	.
cord-015910-d9gxew91	16	1	A	a	DT
cord-015910-d9gxew91	16	2	complex	complex	JJ
cord-015910-d9gxew91	16	3	series	series	NN
cord-015910-d9gxew91	16	4	of	of	IN
cord-015910-d9gxew91	16	5	events	event	NNS
cord-015910-d9gxew91	16	6	follows	follow	VBZ
cord-015910-d9gxew91	16	7	from	from	IN
cord-015910-d9gxew91	16	8	contact	contact	NN
cord-015910-d9gxew91	16	9	between	between	IN
cord-015910-d9gxew91	16	10	components	component	NNS
cord-015910-d9gxew91	16	11	of	of	IN
cord-015910-d9gxew91	16	12	the	the	DT
cord-015910-d9gxew91	16	13	immune	immune	JJ
cord-015910-d9gxew91	16	14	system	system	NN
cord-015910-d9gxew91	16	15	and	and	CC
cord-015910-d9gxew91	16	16	microbes	microbe	NNS
cord-015910-d9gxew91	16	17	invading	invade	VBG
cord-015910-d9gxew91	16	18	the	the	DT
cord-015910-d9gxew91	16	19	body	body	NN
cord-015910-d9gxew91	16	20	(	(	-LRB-
cord-015910-d9gxew91	16	21	Fig	Fig	NNP
cord-015910-d9gxew91	16	22	.	.	.
cord-015910-d9gxew91	16	23	1	1	CD
cord-015910-d9gxew91	16	24	)	)	-RRB-
cord-015910-d9gxew91	16	25	.	.	.
cord-015910-d9gxew91	17	1	The	the	DT
cord-015910-d9gxew91	17	2	response	response	NN
cord-015910-d9gxew91	17	3	can	can	MD
cord-015910-d9gxew91	17	4	be	be	VB
cord-015910-d9gxew91	17	5	divided	divide	VBN
cord-015910-d9gxew91	17	6	into	into	IN
cord-015910-d9gxew91	17	7	two	two	CD
cord-015910-d9gxew91	17	8	main	main	JJ
cord-015910-d9gxew91	17	9	categories	category	NNS
cord-015910-d9gxew91	17	10	.	.	.
cord-015910-d9gxew91	18	1	The	the	DT
cord-015910-d9gxew91	18	2	first	first	JJ
cord-015910-d9gxew91	18	3	is	be	VBZ
cord-015910-d9gxew91	18	4	the	the	DT
cord-015910-d9gxew91	18	5	acquired	acquire	VBN
cord-015910-d9gxew91	18	6	immune	immune	JJ
cord-015910-d9gxew91	18	7	response	response	NN
cord-015910-d9gxew91	18	8	,	,	,
cord-015910-d9gxew91	18	9	in	in	IN
cord-015910-d9gxew91	18	10	which	which	WDT
cord-015910-d9gxew91	18	11	the	the	DT
cord-015910-d9gxew91	18	12	immune	immune	JJ
cord-015910-d9gxew91	18	13	system	system	NN
cord-015910-d9gxew91	18	14	recognizes	recognize	VBZ
cord-015910-d9gxew91	18	15	specific	specific	JJ
cord-015910-d9gxew91	18	16	chemical	chemical	NN
cord-015910-d9gxew91	18	17	motifs	motif	NNS
cord-015910-d9gxew91	18	18	on	on	IN
cord-015910-d9gxew91	18	19	the	the	DT
cord-015910-d9gxew91	18	20	invader	invader	NN
cord-015910-d9gxew91	18	21	and	and	CC
cord-015910-d9gxew91	18	22	"	"	``
cord-015910-d9gxew91	18	23	remembers	remember	VBZ
cord-015910-d9gxew91	18	24	"	"	``
cord-015910-d9gxew91	18	25	the	the	DT
cord-015910-d9gxew91	18	26	encounter	encounter	NN
cord-015910-d9gxew91	18	27	so	so	IN
cord-015910-d9gxew91	18	28	that	that	IN
cord-015910-d9gxew91	18	29	a	a	DT
cord-015910-d9gxew91	18	30	more	more	RBR
cord-015910-d9gxew91	18	31	rapid	rapid	JJ
cord-015910-d9gxew91	18	32	,	,	,
cord-015910-d9gxew91	18	33	specific	specific	JJ
cord-015910-d9gxew91	18	34	,	,	,
cord-015910-d9gxew91	18	35	and	and	CC
cord-015910-d9gxew91	18	36	intense	intense	JJ
cord-015910-d9gxew91	18	37	response	response	NN
cord-015910-d9gxew91	18	38	can	can	MD
cord-015910-d9gxew91	18	39	be	be	VB
cord-015910-d9gxew91	18	40	produced	produce	VBN
cord-015910-d9gxew91	18	41	at	at	IN
cord-015910-d9gxew91	18	42	any	any	DT
cord-015910-d9gxew91	18	43	future	future	JJ
cord-015910-d9gxew91	18	44	meeting	meeting	NN
cord-015910-d9gxew91	18	45	.	.	.
cord-015910-d9gxew91	19	1	The	the	DT
cord-015910-d9gxew91	19	2	second	second	JJ
cord-015910-d9gxew91	19	3	category	category	NN
cord-015910-d9gxew91	19	4	is	be	VBZ
cord-015910-d9gxew91	19	5	the	the	DT
cord-015910-d9gxew91	19	6	nonspeciflc	nonspeciflc	NNP
cord-015910-d9gxew91	19	7	response	response	NN
cord-015910-d9gxew91	19	8	in	in	IN
cord-015910-d9gxew91	19	9	which	which	WDT
cord-015910-d9gxew91	19	10	the	the	DT
cord-015910-d9gxew91	19	11	response	response	NN
cord-015910-d9gxew91	19	12	to	to	IN
cord-015910-d9gxew91	19	13	each	each	DT
cord-015910-d9gxew91	19	14	encounter	encounter	NN
cord-015910-d9gxew91	19	15	is	be	VBZ
cord-015910-d9gxew91	19	16	similar	similar	JJ
cord-015910-d9gxew91	19	17	for	for	IN
cord-015910-d9gxew91	19	18	all	all	DT
cord-015910-d9gxew91	19	19	invaders	invader	NNS
cord-015910-d9gxew91	19	20	of	of	IN
cord-015910-d9gxew91	19	21	the	the	DT
cord-015910-d9gxew91	19	22	body	body	NN
cord-015910-d9gxew91	19	23	.	.	.
cord-015910-d9gxew91	20	1	The	the	DT
cord-015910-d9gxew91	20	2	process	process	NN
cord-015910-d9gxew91	20	3	of	of	IN
cord-015910-d9gxew91	20	4	inflammation	inflammation	NN
cord-015910-d9gxew91	20	5	is	be	VBZ
cord-015910-d9gxew91	20	6	a	a	DT
cord-015910-d9gxew91	20	7	central	central	JJ
cord-015910-d9gxew91	20	8	part	part	NN
cord-015910-d9gxew91	20	9	of	of	IN
cord-015910-d9gxew91	20	10	the	the	DT
cord-015910-d9gxew91	20	11	second	second	JJ
cord-015910-d9gxew91	20	12	category	category	NN
cord-015910-d9gxew91	20	13	of	of	IN
cord-015910-d9gxew91	20	14	response	response	NN
cord-015910-d9gxew91	20	15	.	.	.
cord-015910-d9gxew91	21	1	The	the	DT
cord-015910-d9gxew91	21	2	immune	immune	JJ
cord-015910-d9gxew91	21	3	response	response	NN
cord-015910-d9gxew91	21	4	is	be	VBZ
cord-015910-d9gxew91	21	5	also	also	RB
cord-015910-d9gxew91	21	6	activated	activate	VBN
cord-015910-d9gxew91	21	7	by	by	IN
cord-015910-d9gxew91	21	8	a	a	DT
cord-015910-d9gxew91	21	9	wide	wide	JJ
cord-015910-d9gxew91	21	10	range	range	NN
cord-015910-d9gxew91	21	11	of	of	IN
cord-015910-d9gxew91	21	12	adverse	adverse	JJ
cord-015910-d9gxew91	21	13	events	event	NNS
cord-015910-d9gxew91	21	14	,	,	,
cord-015910-d9gxew91	21	15	such	such	JJ
cord-015910-d9gxew91	21	16	as	as	IN
cord-015910-d9gxew91	21	17	surgery	surgery	NN
cord-015910-d9gxew91	21	18	,	,	,
cord-015910-d9gxew91	21	19	bums	bum	NNS
cord-015910-d9gxew91	21	20	,	,	,
cord-015910-d9gxew91	21	21	and	and	CC
cord-015910-d9gxew91	21	22	trauma	trauma	NN
cord-015910-d9gxew91	21	23	.	.	.
cord-015910-d9gxew91	22	1	The	the	DT
cord-015910-d9gxew91	22	2	primary	primary	JJ
cord-015910-d9gxew91	22	3	purposes	purpose	NNS
cord-015910-d9gxew91	22	4	of	of	IN
cord-015910-d9gxew91	22	5	the	the	DT
cord-015910-d9gxew91	22	6	response	response	NN
cord-015910-d9gxew91	22	7	are	be	VBP
cord-015910-d9gxew91	22	8	to	to	TO
cord-015910-d9gxew91	22	9	kill	kill	VB
cord-015910-d9gxew91	22	10	pathogens	pathogen	NNS
cord-015910-d9gxew91	22	11	and	and	CC
cord-015910-d9gxew91	22	12	initiate	initiate	VB
cord-015910-d9gxew91	22	13	the	the	DT
cord-015910-d9gxew91	22	14	curative	curative	JJ
cord-015910-d9gxew91	22	15	processes	process	NNS
cord-015910-d9gxew91	22	16	that	that	WDT
cord-015910-d9gxew91	22	17	will	will	MD
cord-015910-d9gxew91	22	18	restore	restore	VB
cord-015910-d9gxew91	22	19	body	body	NN
cord-015910-d9gxew91	22	20	function	function	NN
cord-015910-d9gxew91	22	21	to	to	IN
cord-015910-d9gxew91	22	22	normal	normal	JJ
cord-015910-d9gxew91	22	23	.	.	.
cord-015910-d9gxew91	23	1	The	the	DT
cord-015910-d9gxew91	23	2	first	first	JJ
cord-015910-d9gxew91	23	3	purpose	purpose	NN
cord-015910-d9gxew91	23	4	is	be	VBZ
cord-015910-d9gxew91	23	5	achieved	achieve	VBN
cord-015910-d9gxew91	23	6	by	by	IN
cord-015910-d9gxew91	23	7	creating	create	VBG
cord-015910-d9gxew91	23	8	a	a	DT
cord-015910-d9gxew91	23	9	hostile	hostile	JJ
cord-015910-d9gxew91	23	10	tissue	tissue	NN
cord-015910-d9gxew91	23	11	environment	environment	NN
cord-015910-d9gxew91	23	12	through	through	IN
cord-015910-d9gxew91	23	13	production	production	NN
cord-015910-d9gxew91	23	14	of	of	IN
cord-015910-d9gxew91	23	15	oxidant	oxidant	JJ
cord-015910-d9gxew91	23	16	molecules	molecule	NNS
cord-015910-d9gxew91	23	17	and	and	CC
cord-015910-d9gxew91	23	18	activation	activation	NN
cord-015910-d9gxew91	23	19	of	of	IN
cord-015910-d9gxew91	23	20	T	t	NN
cord-015910-d9gxew91	23	21	and	and	CC
cord-015910-d9gxew91	23	22	B	b	NN
cord-015910-d9gxew91	23	23	lymphocytes	lymphocyte	NNS
cord-015910-d9gxew91	23	24	.	.	.
cord-015910-d9gxew91	24	1	Part	part	NN
cord-015910-d9gxew91	24	2	of	of	IN
cord-015910-d9gxew91	24	3	the	the	DT
cord-015910-d9gxew91	24	4	response	response	NN
cord-015910-d9gxew91	24	5	ensures	ensure	VBZ
cord-015910-d9gxew91	24	6	a	a	DT
cord-015910-d9gxew91	24	7	supply	supply	NN
cord-015910-d9gxew91	24	8	of	of	IN
cord-015910-d9gxew91	24	9	substrate	substrate	NN
cord-015910-d9gxew91	24	10	,	,	,
cord-015910-d9gxew91	24	11	from	from	IN
cord-015910-d9gxew91	24	12	endogenous	endogenous	JJ
cord-015910-d9gxew91	24	13	sources	source	NNS
cord-015910-d9gxew91	24	14	,	,	,
cord-015910-d9gxew91	24	15	for	for	IN
cord-015910-d9gxew91	24	16	supporting	support	VBG
cord-015910-d9gxew91	24	17	the	the	DT
cord-015910-d9gxew91	24	18	activity	activity	NN
cord-015910-d9gxew91	24	19	of	of	IN
cord-015910-d9gxew91	24	20	T	t	NN
cord-015910-d9gxew91	24	21	and	and	CC
cord-015910-d9gxew91	24	22	B	b	NN
cord-015910-d9gxew91	24	23	lymphocytes	lymphocyte	NNS
cord-015910-d9gxew91	24	24	and	and	CC
cord-015910-d9gxew91	24	25	enhancement	enhancement	NN
cord-015910-d9gxew91	24	26	of	of	IN
cord-015910-d9gxew91	24	27	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	24	28	defenses	defense	NNS
cord-015910-d9gxew91	24	29	.	.	.
cord-015910-d9gxew91	25	1	The	the	DT
cord-015910-d9gxew91	25	2	latter	latter	JJ
cord-015910-d9gxew91	25	3	event	event	NN
cord-015910-d9gxew91	25	4	is	be	VBZ
cord-015910-d9gxew91	25	5	important	important	JJ
cord-015910-d9gxew91	25	6	for	for	IN
cord-015910-d9gxew91	25	7	protecting	protect	VBG
cord-015910-d9gxew91	25	8	healthy	healthy	JJ
cord-015910-d9gxew91	25	9	tissue	tissue	NN
cord-015910-d9gxew91	25	10	from	from	IN
cord-015910-d9gxew91	25	11	the	the	DT
cord-015910-d9gxew91	25	12	oxidants	oxidant	NNS
cord-015910-d9gxew91	25	13	produced	produce	VBN
cord-015910-d9gxew91	25	14	as	as	IN
cord-015910-d9gxew91	25	15	part	part	NN
cord-015910-d9gxew91	25	16	of	of	IN
cord-015910-d9gxew91	25	17	the	the	DT
cord-015910-d9gxew91	25	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	25	19	response	response	NN
cord-015910-d9gxew91	25	20	(	(	-LRB-
cord-015910-d9gxew91	25	21	Grimble	Grimble	NNP
cord-015910-d9gxew91	25	22	,	,	,
cord-015910-d9gxew91	25	23	2001	2001	CD
cord-015910-d9gxew91	25	24	a	a	LS
cord-015910-d9gxew91	25	25	)	)	-RRB-
cord-015910-d9gxew91	25	26	.	.	.
cord-015910-d9gxew91	26	1	The	the	DT
cord-015910-d9gxew91	26	2	response	response	NN
cord-015910-d9gxew91	26	3	exerts	exert	VBZ
cord-015910-d9gxew91	26	4	considerable	considerable	JJ
cord-015910-d9gxew91	26	5	biological	biological	JJ
cord-015910-d9gxew91	26	6	demands	demand	NNS
cord-015910-d9gxew91	26	7	and	and	CC
cord-015910-d9gxew91	26	8	stress	stress	NN
cord-015910-d9gxew91	26	9	on	on	IN
cord-015910-d9gxew91	26	10	the	the	DT
cord-015910-d9gxew91	26	11	body	body	NN
cord-015910-d9gxew91	26	12	.	.	.
cord-015910-d9gxew91	27	1	A	a	DT
cord-015910-d9gxew91	27	2	central	central	JJ
cord-015910-d9gxew91	27	3	part	part	NN
cord-015910-d9gxew91	27	4	of	of	IN
cord-015910-d9gxew91	27	5	substrate	substrate	JJ
cord-015910-d9gxew91	27	6	provision	provision	NN
cord-015910-d9gxew91	27	7	is	be	VBZ
cord-015910-d9gxew91	27	8	the	the	DT
cord-015910-d9gxew91	27	9	release	release	NN
cord-015910-d9gxew91	27	10	of	of	IN
cord-015910-d9gxew91	27	11	amino	amino	JJ
cord-015910-d9gxew91	27	12	acids	acid	NNS
cord-015910-d9gxew91	27	13	into	into	IN
cord-015910-d9gxew91	27	14	the	the	DT
cord-015910-d9gxew91	27	15	blood	blood	NN
cord-015910-d9gxew91	27	16	from	from	IN
cord-015910-d9gxew91	27	17	the	the	DT
cord-015910-d9gxew91	27	18	breakdown	breakdown	NN
cord-015910-d9gxew91	27	19	of	of	IN
cord-015910-d9gxew91	27	20	proteins	protein	NNS
cord-015910-d9gxew91	27	21	in	in	IN
cord-015910-d9gxew91	27	22	skeletal	skeletal	JJ
cord-015910-d9gxew91	27	23	muscle	muscle	NN
cord-015910-d9gxew91	27	24	,	,	,
cord-015910-d9gxew91	27	25	skin	skin	NN
cord-015910-d9gxew91	27	26	,	,	,
cord-015910-d9gxew91	27	27	and	and	CC
cord-015910-d9gxew91	27	28	bone	bone	NN
cord-015910-d9gxew91	27	29	matrix	matrix	NN
cord-015910-d9gxew91	27	30	,	,	,
cord-015910-d9gxew91	27	31	and	and	CC
cord-015910-d9gxew91	27	32	fatty	fatty	JJ
cord-015910-d9gxew91	27	33	acids	acid	NNS
cord-015910-d9gxew91	27	34	released	release	VBN
cord-015910-d9gxew91	27	35	from	from	IN
cord-015910-d9gxew91	27	36	triglycerides	triglyceride	NNS
cord-015910-d9gxew91	27	37	stored	store	VBN
cord-015910-d9gxew91	27	38	in	in	IN
cord-015910-d9gxew91	27	39	adipose	adipose	JJ
cord-015910-d9gxew91	27	40	tissue	tissue	NN
cord-015910-d9gxew91	27	41	.	.	.
cord-015910-d9gxew91	28	1	Enhanced	enhance	VBN
cord-015910-d9gxew91	28	2	gluconeogenesis	gluconeogenesis	NN
cord-015910-d9gxew91	28	3	,	,	,
cord-015910-d9gxew91	28	4	catabolic	catabolic	JJ
cord-015910-d9gxew91	28	5	hormone	hormone	NN
cord-015910-d9gxew91	28	6	production	production	NN
cord-015910-d9gxew91	28	7	,	,	,
cord-015910-d9gxew91	28	8	and	and	CC
cord-015910-d9gxew91	28	9	decreased	decrease	VBD
cord-015910-d9gxew91	28	10	insulin	insulin	NN
cord-015910-d9gxew91	28	11	sensitivity	sensitivity	NN
cord-015910-d9gxew91	28	12	occurs	occur	VBZ
cord-015910-d9gxew91	28	13	to	to	TO
cord-015910-d9gxew91	28	14	facilitate	facilitate	VB
cord-015910-d9gxew91	28	15	this	this	DT
cord-015910-d9gxew91	28	16	redistribution	redistribution	NN
cord-015910-d9gxew91	28	17	of	of	IN
cord-015910-d9gxew91	28	18	tissue	tissue	NN
cord-015910-d9gxew91	28	19	Infective	Infective	NNP
cord-015910-d9gxew91	28	20	or	or	CC
cord-015910-d9gxew91	28	21	cellular	cellular	JJ
cord-015910-d9gxew91	28	22	Fig	fig	NN
cord-015910-d9gxew91	28	23	.	.	.
cord-015910-d9gxew91	29	1	2	2	LS
cord-015910-d9gxew91	29	2	.	.	.
cord-015910-d9gxew91	30	1	Diseases	disease	NNS
cord-015910-d9gxew91	30	2	and	and	CC
cord-015910-d9gxew91	30	3	conditions	condition	NNS
cord-015910-d9gxew91	30	4	in	in	IN
cord-015910-d9gxew91	30	5	which	which	WDT
cord-015910-d9gxew91	30	6	inappropriate	inappropriate	JJ
cord-015910-d9gxew91	30	7	or	or	CC
cord-015910-d9gxew91	30	8	excessive	excessive	JJ
cord-015910-d9gxew91	30	9	amounts	amount	NNS
cord-015910-d9gxew91	30	10	of	of	IN
cord-015910-d9gxew91	30	11	pro	pro	JJ
cord-015910-d9gxew91	30	12	-	-	JJ
cord-015910-d9gxew91	30	13	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	30	14	cytokines	cytokine	NNS
cord-015910-d9gxew91	30	15	exert	exert	VBP
cord-015910-d9gxew91	30	16	adverse	adverse	JJ
cord-015910-d9gxew91	30	17	or	or	CC
cord-015910-d9gxew91	30	18	lethal	lethal	JJ
cord-015910-d9gxew91	30	19	effects	effect	NNS
cord-015910-d9gxew91	30	20	on	on	IN
cord-015910-d9gxew91	30	21	the	the	DT
cord-015910-d9gxew91	30	22	host	host	NN
cord-015910-d9gxew91	30	23	.	.	.
cord-015910-d9gxew91	31	1	components	component	NNS
cord-015910-d9gxew91	31	2	(	(	-LRB-
cord-015910-d9gxew91	31	3	Fig	Fig	NNP
cord-015910-d9gxew91	31	4	.	.	NNP
cord-015910-d9gxew91	31	5	1	1	CD
cord-015910-d9gxew91	31	6	)	)	-RRB-
cord-015910-d9gxew91	31	7	.	.	.
cord-015910-d9gxew91	32	1	The	the	DT
cord-015910-d9gxew91	32	2	animal	animal	NN
cord-015910-d9gxew91	32	3	loses	lose	VBZ
cord-015910-d9gxew91	32	4	the	the	DT
cord-015910-d9gxew91	32	5	desire	desire	NN
cord-015910-d9gxew91	32	6	to	to	TO
cord-015910-d9gxew91	32	7	carry	carry	VB
cord-015910-d9gxew91	32	8	out	out	RP
cord-015910-d9gxew91	32	9	many	many	JJ
cord-015910-d9gxew91	32	10	day	day	NN
cord-015910-d9gxew91	32	11	-	-	HYPH
cord-015910-d9gxew91	32	12	to	to	IN
cord-015910-d9gxew91	32	13	-	-	HYPH
cord-015910-d9gxew91	32	14	day	day	NN
cord-015910-d9gxew91	32	15	activities	activity	NNS
cord-015910-d9gxew91	32	16	.	.	.
cord-015910-d9gxew91	33	1	Physical	physical	JJ
cord-015910-d9gxew91	33	2	weakness	weakness	NN
cord-015910-d9gxew91	33	3	ensues	ensue	VBZ
cord-015910-d9gxew91	33	4	,	,	,
cord-015910-d9gxew91	33	5	exploratory	exploratory	JJ
cord-015910-d9gxew91	33	6	activity	activity	NN
cord-015910-d9gxew91	33	7	declines	decline	NNS
cord-015910-d9gxew91	33	8	,	,	,
cord-015910-d9gxew91	33	9	appetite	appetite	NN
cord-015910-d9gxew91	33	10	is	be	VBZ
cord-015910-d9gxew91	33	11	decreased	decrease	VBN
cord-015910-d9gxew91	33	12	,	,	,
cord-015910-d9gxew91	33	13	and	and	CC
cord-015910-d9gxew91	33	14	apathy	apathy	NN
cord-015910-d9gxew91	33	15	and	and	CC
cord-015910-d9gxew91	33	16	sleep	sleep	NN
cord-015910-d9gxew91	33	17	may	may	MD
cord-015910-d9gxew91	33	18	occur	occur	VB
cord-015910-d9gxew91	33	19	.	.	.
cord-015910-d9gxew91	34	1	The	the	DT
cord-015910-d9gxew91	34	2	response	response	NN
cord-015910-d9gxew91	34	3	thus	thus	RB
cord-015910-d9gxew91	34	4	exerts	exert	VBZ
cord-015910-d9gxew91	34	5	physiological	physiological	JJ
cord-015910-d9gxew91	34	6	and	and	CC
cord-015910-d9gxew91	34	7	mental	mental	JJ
cord-015910-d9gxew91	34	8	stress	stress	NN
cord-015910-d9gxew91	34	9	upon	upon	IN
cord-015910-d9gxew91	34	10	the	the	DT
cord-015910-d9gxew91	34	11	body	body	NN
cord-015910-d9gxew91	34	12	.	.	.
cord-015910-d9gxew91	35	1	Inflammation	inflammation	NN
cord-015910-d9gxew91	35	2	comes	come	VBZ
cord-015910-d9gxew91	35	3	under	under	IN
cord-015910-d9gxew91	35	4	the	the	DT
cord-015910-d9gxew91	35	5	control	control	NN
cord-015910-d9gxew91	35	6	of	of	IN
cord-015910-d9gxew91	35	7	signaling	signal	VBG
cord-015910-d9gxew91	35	8	proteins	protein	NNS
cord-015910-d9gxew91	35	9	(	(	-LRB-
cord-015910-d9gxew91	35	10	cytokines	cytokine	NNS
cord-015910-d9gxew91	35	11	)	)	-RRB-
cord-015910-d9gxew91	35	12	that	that	WDT
cord-015910-d9gxew91	35	13	possess	possess	VBP
cord-015910-d9gxew91	35	14	hormone	hormone	NN
cord-015910-d9gxew91	35	15	-	-	HYPH
cord-015910-d9gxew91	35	16	like	like	JJ
cord-015910-d9gxew91	35	17	actions	action	NNS
cord-015910-d9gxew91	35	18	.	.	.
cord-015910-d9gxew91	36	1	The	the	DT
cord-015910-d9gxew91	36	2	pro	pro	JJ
cord-015910-d9gxew91	36	3	-	-	JJ
cord-015910-d9gxew91	36	4	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	36	5	cytokines	cytokine	NNS
cord-015910-d9gxew91	36	6	interleukin	interleukin	NN
cord-015910-d9gxew91	36	7	(	(	-LRB-
cord-015910-d9gxew91	36	8	IL)-113	IL)-113	NNS
cord-015910-d9gxew91	36	9	,	,	,
cord-015910-d9gxew91	36	10	IL-6	IL-6	NNP
cord-015910-d9gxew91	36	11	,	,	,
cord-015910-d9gxew91	36	12	and	and	CC
cord-015910-d9gxew91	36	13	tumor	tumor	NN
cord-015910-d9gxew91	36	14	necrosis	necrosis	NN
cord-015910-d9gxew91	36	15	factor	factor	NN
cord-015910-d9gxew91	37	1	(	(	-LRB-
cord-015910-d9gxew91	37	2	TNF)-t~	tnf)-t~	UH
cord-015910-d9gxew91	37	3	,	,	,
cord-015910-d9gxew91	37	4	are	be	VBP
cord-015910-d9gxew91	37	5	major	major	JJ
cord-015910-d9gxew91	37	6	activators	activator	NNS
cord-015910-d9gxew91	37	7	and	and	CC
cord-015910-d9gxew91	37	8	modulators	modulator	NNS
cord-015910-d9gxew91	37	9	of	of	IN
cord-015910-d9gxew91	37	10	the	the	DT
cord-015910-d9gxew91	37	11	events	event	NNS
cord-015910-d9gxew91	37	12	described	describe	VBN
cord-015910-d9gxew91	37	13	above	above	RB
cord-015910-d9gxew91	37	14	.	.	.
cord-015910-d9gxew91	38	1	To	to	TO
cord-015910-d9gxew91	38	2	modulate	modulate	VB
cord-015910-d9gxew91	38	3	the	the	DT
cord-015910-d9gxew91	38	4	degree	degree	NN
cord-015910-d9gxew91	38	5	of	of	IN
cord-015910-d9gxew91	38	6	stress	stress	NN
cord-015910-d9gxew91	38	7	imposed	impose	VBN
cord-015910-d9gxew91	38	8	on	on	IN
cord-015910-d9gxew91	38	9	the	the	DT
cord-015910-d9gxew91	38	10	body	body	NN
cord-015910-d9gxew91	38	11	,	,	,
cord-015910-d9gxew91	38	12	in	in	IN
cord-015910-d9gxew91	38	13	achieving	achieve	VBG
cord-015910-d9gxew91	38	14	the	the	DT
cord-015910-d9gxew91	38	15	essential	essential	JJ
cord-015910-d9gxew91	38	16	functions	function	NNS
cord-015910-d9gxew91	38	17	of	of	IN
cord-015910-d9gxew91	38	18	inflammation	inflammation	NN
cord-015910-d9gxew91	38	19	,	,	,
cord-015910-d9gxew91	38	20	the	the	DT
cord-015910-d9gxew91	38	21	response	response	NN
cord-015910-d9gxew91	38	22	comes	come	VBZ
cord-015910-d9gxew91	38	23	under	under	IN
cord-015910-d9gxew91	38	24	the	the	DT
cord-015910-d9gxew91	38	25	control	control	NN
cord-015910-d9gxew91	38	26	of	of	IN
cord-015910-d9gxew91	38	27	powerful	powerful	JJ
cord-015910-d9gxew91	38	28	anti	anti	JJ
cord-015910-d9gxew91	38	29	-	-	JJ
cord-015910-d9gxew91	38	30	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	38	31	mechanisms	mechanism	NNS
cord-015910-d9gxew91	38	32	.	.	.
cord-015910-d9gxew91	39	1	These	these	DT
cord-015910-d9gxew91	39	2	will	will	MD
cord-015910-d9gxew91	39	3	impose	impose	VB
cord-015910-d9gxew91	39	4	their	-PRON-	PRP$
cord-015910-d9gxew91	39	5	biological	biological	JJ
cord-015910-d9gxew91	39	6	effects	effect	NNS
cord-015910-d9gxew91	39	7	with	with	IN
cord-015910-d9gxew91	39	8	increasing	increase	VBG
cord-015910-d9gxew91	39	9	vigor	vigor	NN
cord-015910-d9gxew91	39	10	as	as	IN
cord-015910-d9gxew91	39	11	the	the	DT
cord-015910-d9gxew91	39	12	original	original	JJ
cord-015910-d9gxew91	39	13	stimulus	stimulus	NN
cord-015910-d9gxew91	39	14	for	for	IN
cord-015910-d9gxew91	39	15	the	the	DT
cord-015910-d9gxew91	39	16	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	39	17	response	response	NN
cord-015910-d9gxew91	39	18	(	(	-LRB-
cord-015910-d9gxew91	39	19	infection	infection	NN
cord-015910-d9gxew91	39	20	,	,	,
cord-015910-d9gxew91	39	21	injury	injury	NN
cord-015910-d9gxew91	39	22	)	)	-RRB-
cord-015910-d9gxew91	39	23	declines	decline	NNS
cord-015910-d9gxew91	39	24	in	in	IN
cord-015910-d9gxew91	39	25	intensity	intensity	NN
cord-015910-d9gxew91	39	26	.	.	.
cord-015910-d9gxew91	40	1	Heat	heat	NN
cord-015910-d9gxew91	40	2	-	-	HYPH
cord-015910-d9gxew91	40	3	shock	shock	NN
cord-015910-d9gxew91	40	4	proteins	protein	NNS
cord-015910-d9gxew91	40	5	,	,	,
cord-015910-d9gxew91	40	6	endorphins	endorphin	NNS
cord-015910-d9gxew91	40	7	,	,	,
cord-015910-d9gxew91	40	8	glucocorticoid	glucocorticoid	NN
cord-015910-d9gxew91	40	9	hormones	hormone	NNS
cord-015910-d9gxew91	40	10	,	,	,
cord-015910-d9gxew91	40	11	and	and	CC
cord-015910-d9gxew91	40	12	cytokine	cytokine	JJ
cord-015910-d9gxew91	40	13	receptor	receptor	NN
cord-015910-d9gxew91	40	14	antagonists	antagonist	NNS
cord-015910-d9gxew91	40	15	are	be	VBP
cord-015910-d9gxew91	40	16	important	important	JJ
cord-015910-d9gxew91	40	17	components	component	NNS
cord-015910-d9gxew91	40	18	of	of	IN
cord-015910-d9gxew91	40	19	this	this	DT
cord-015910-d9gxew91	40	20	anti	anti	JJ
cord-015910-d9gxew91	40	21	-	-	JJ
cord-015910-d9gxew91	40	22	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	40	23	system	system	NN
cord-015910-d9gxew91	40	24	.	.	.
cord-015910-d9gxew91	41	1	This	this	DT
cord-015910-d9gxew91	41	2	system	system	NN
cord-015910-d9gxew91	41	3	is	be	VBZ
cord-015910-d9gxew91	41	4	essential	essential	JJ
cord-015910-d9gxew91	41	5	for	for	IN
cord-015910-d9gxew91	41	6	closing	close	VBG
cord-015910-d9gxew91	41	7	down	down	RP
cord-015910-d9gxew91	41	8	the	the	DT
cord-015910-d9gxew91	41	9	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	41	10	response	response	NN
cord-015910-d9gxew91	41	11	once	once	IN
cord-015910-d9gxew91	41	12	it	-PRON-	PRP
cord-015910-d9gxew91	41	13	has	have	VBZ
cord-015910-d9gxew91	41	14	achieved	achieve	VBN
cord-015910-d9gxew91	41	15	its	-PRON-	PRP$
cord-015910-d9gxew91	41	16	primary	primary	JJ
cord-015910-d9gxew91	41	17	purposes	purpose	NNS
cord-015910-d9gxew91	41	18	because	because	IN
cord-015910-d9gxew91	41	19	of	of	IN
cord-015910-d9gxew91	41	20	the	the	DT
cord-015910-d9gxew91	41	21	high	high	JJ
cord-015910-d9gxew91	41	22	biological	biological	JJ
cord-015910-d9gxew91	41	23	cost	cost	NN
cord-015910-d9gxew91	41	24	it	-PRON-	PRP
cord-015910-d9gxew91	41	25	imposes	impose	VBZ
cord-015910-d9gxew91	41	26	on	on	IN
cord-015910-d9gxew91	41	27	the	the	DT
cord-015910-d9gxew91	41	28	body	body	NN
cord-015910-d9gxew91	41	29	(	(	-LRB-
cord-015910-d9gxew91	41	30	Grimble	Grimble	NNP
cord-015910-d9gxew91	41	31	,	,	,
cord-015910-d9gxew91	41	32	2001	2001	CD
cord-015910-d9gxew91	41	33	a	a	LS
cord-015910-d9gxew91	41	34	)	)	-RRB-
cord-015910-d9gxew91	41	35	.	.	.
cord-015910-d9gxew91	42	1	Although	although	IN
cord-015910-d9gxew91	42	2	cytokines	cytokine	NNS
cord-015910-d9gxew91	42	3	play	play	VBP
cord-015910-d9gxew91	42	4	an	an	DT
cord-015910-d9gxew91	42	5	important	important	JJ
cord-015910-d9gxew91	42	6	role	role	NN
cord-015910-d9gxew91	42	7	in	in	IN
cord-015910-d9gxew91	42	8	the	the	DT
cord-015910-d9gxew91	42	9	response	response	NN
cord-015910-d9gxew91	42	10	to	to	IN
cord-015910-d9gxew91	42	11	infection	infection	NN
cord-015910-d9gxew91	42	12	and	and	CC
cord-015910-d9gxew91	42	13	injury	injury	NN
cord-015910-d9gxew91	42	14	,	,	,
cord-015910-d9gxew91	42	15	they	-PRON-	PRP
cord-015910-d9gxew91	42	16	can	can	MD
cord-015910-d9gxew91	42	17	exert	exert	VB
cord-015910-d9gxew91	42	18	damaging	damaging	JJ
cord-015910-d9gxew91	42	19	and	and	CC
cord-015910-d9gxew91	42	20	lethal	lethal	JJ
cord-015910-d9gxew91	42	21	effects	effect	NNS
cord-015910-d9gxew91	42	22	on	on	IN
cord-015910-d9gxew91	42	23	the	the	DT
cord-015910-d9gxew91	42	24	host	host	NN
cord-015910-d9gxew91	42	25	.	.	.
cord-015910-d9gxew91	43	1	Many	many	JJ
cord-015910-d9gxew91	43	2	studies	study	NNS
cord-015910-d9gxew91	43	3	have	have	VBP
cord-015910-d9gxew91	43	4	shown	show	VBN
cord-015910-d9gxew91	43	5	that	that	IN
cord-015910-d9gxew91	43	6	excessive	excessive	JJ
cord-015910-d9gxew91	43	7	or	or	CC
cord-015910-d9gxew91	43	8	prolonged	prolonged	JJ
cord-015910-d9gxew91	43	9	production	production	NN
cord-015910-d9gxew91	43	10	of	of	IN
cord-015910-d9gxew91	43	11	cytokines	cytokine	NNS
cord-015910-d9gxew91	43	12	is	be	VBZ
cord-015910-d9gxew91	43	13	associated	associate	VBN
cord-015910-d9gxew91	43	14	with	with	IN
cord-015910-d9gxew91	43	15	increased	increase	VBN
cord-015910-d9gxew91	43	16	morbidity	morbidity	NN
cord-015910-d9gxew91	43	17	and	and	CC
cord-015910-d9gxew91	43	18	mortality	mortality	NN
cord-015910-d9gxew91	43	19	in	in	IN
cord-015910-d9gxew91	43	20	a	a	DT
cord-015910-d9gxew91	43	21	wide	wide	JJ
cord-015910-d9gxew91	43	22	range	range	NN
cord-015910-d9gxew91	43	23	of	of	IN
cord-015910-d9gxew91	43	24	acute	acute	JJ
cord-015910-d9gxew91	43	25	and	and	CC
cord-015910-d9gxew91	43	26	chronic	chronic	JJ
cord-015910-d9gxew91	43	27	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	43	28	conditions	condition	NNS
cord-015910-d9gxew91	43	29	(	(	-LRB-
cord-015910-d9gxew91	43	30	Fig	fig	NN
cord-015910-d9gxew91	43	31	.	.	NNP
cord-015910-d9gxew91	43	32	2	2	CD
cord-015910-d9gxew91	43	33	)	)	-RRB-
cord-015910-d9gxew91	43	34	.	.	.
cord-015910-d9gxew91	44	1	These	these	DT
cord-015910-d9gxew91	44	2	include	include	VBP
cord-015910-d9gxew91	44	3	sepsis	sepsis	NN
cord-015910-d9gxew91	44	4	,	,	,
cord-015910-d9gxew91	44	5	adult	adult	NN
cord-015910-d9gxew91	44	6	respiratory	respiratory	JJ
cord-015910-d9gxew91	44	7	distress	distress	NN
cord-015910-d9gxew91	44	8	syndrome	syndrome	NN
cord-015910-d9gxew91	44	9	,	,	,
cord-015910-d9gxew91	44	10	malaria	malaria	NN
cord-015910-d9gxew91	44	11	,	,	,
cord-015910-d9gxew91	44	12	meningitis	meningitis	NN
cord-015910-d9gxew91	44	13	,	,	,
cord-015910-d9gxew91	44	14	cancer	cancer	NN
cord-015910-d9gxew91	44	15	,	,	,
cord-015910-d9gxew91	44	16	cystic	cystic	JJ
cord-015910-d9gxew91	44	17	fibrosis	fibrosis	NN
cord-015910-d9gxew91	44	18	,	,	,
cord-015910-d9gxew91	44	19	systemic	systemic	JJ
cord-015910-d9gxew91	44	20	lupus	lupus	NN
cord-015910-d9gxew91	44	21	erythematosus	erythematosus	NN
cord-015910-d9gxew91	44	22	,	,	,
cord-015910-d9gxew91	44	23	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	44	24	bowel	bowel	NN
cord-015910-d9gxew91	44	25	disease	disease	NN
cord-015910-d9gxew91	44	26	,	,	,
cord-015910-d9gxew91	44	27	rheumatoid	rheumatoid	NN
cord-015910-d9gxew91	44	28	arthritis	arthritis	NN
cord-015910-d9gxew91	44	29	,	,	,
cord-015910-d9gxew91	44	30	and	and	CC
cord-015910-d9gxew91	44	31	asthma	asthma	NN
cord-015910-d9gxew91	44	32	.	.	.
cord-015910-d9gxew91	45	1	Events	event	NNS
cord-015910-d9gxew91	45	2	similar	similar	JJ
cord-015910-d9gxew91	45	3	to	to	IN
cord-015910-d9gxew91	45	4	those	those	DT
cord-015910-d9gxew91	45	5	seen	see	VBN
cord-015910-d9gxew91	45	6	in	in	IN
cord-015910-d9gxew91	45	7	the	the	DT
cord-015910-d9gxew91	45	8	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	45	9	response	response	NN
cord-015910-d9gxew91	45	10	to	to	IN
cord-015910-d9gxew91	45	11	injury	injury	NN
cord-015910-d9gxew91	45	12	and	and	CC
cord-015910-d9gxew91	45	13	infection	infection	NN
cord-015910-d9gxew91	45	14	can	can	MD
cord-015910-d9gxew91	45	15	be	be	VB
cord-015910-d9gxew91	45	16	observed	observe	VBN
cord-015910-d9gxew91	45	17	during	during	IN
cord-015910-d9gxew91	45	18	the	the	DT
cord-015910-d9gxew91	45	19	course	course	NN
cord-015910-d9gxew91	45	20	of	of	IN
cord-015910-d9gxew91	45	21	overt	overt	JJ
cord-015910-d9gxew91	45	22	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	45	23	diseases	disease	NNS
cord-015910-d9gxew91	45	24	such	such	JJ
cord-015910-d9gxew91	45	25	as	as	IN
cord-015910-d9gxew91	45	26	rheumatoid	rheumatoid	JJ
cord-015910-d9gxew91	45	27	arthritis	arthritis	NN
cord-015910-d9gxew91	45	28	and	and	CC
cord-015910-d9gxew91	45	29	Crohn	Crohn	NNP
cord-015910-d9gxew91	45	30	's	's	POS
cord-015910-d9gxew91	45	31	disease	disease	NN
cord-015910-d9gxew91	45	32	and	and	CC
cord-015910-d9gxew91	45	33	in	in	IN
cord-015910-d9gxew91	45	34	diseases	disease	NNS
cord-015910-d9gxew91	45	35	that	that	WDT
cord-015910-d9gxew91	45	36	have	have	VBP
cord-015910-d9gxew91	45	37	a	a	DT
cord-015910-d9gxew91	45	38	covert	covert	JJ
cord-015910-d9gxew91	45	39	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	45	40	basis	basis	NN
cord-015910-d9gxew91	45	41	,	,	,
cord-015910-d9gxew91	45	42	for	for	IN
cord-015910-d9gxew91	45	43	example	example	NN
cord-015910-d9gxew91	45	44	,	,	,
cord-015910-d9gxew91	45	45	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	45	46	and	and	CC
cord-015910-d9gxew91	45	47	diabetes	diabetes	NN
cord-015910-d9gxew91	45	48	mellitus	mellitus	NN
cord-015910-d9gxew91	45	49	(	(	-LRB-
cord-015910-d9gxew91	45	50	Fig	Fig	NNP
cord-015910-d9gxew91	45	51	.	.	.
cord-015910-d9gxew91	45	52	3	3	CD
cord-015910-d9gxew91	45	53	)	)	-RRB-
cord-015910-d9gxew91	45	54	.	.	.
cord-015910-d9gxew91	46	1	Clearly	clearly	RB
cord-015910-d9gxew91	46	2	the	the	DT
cord-015910-d9gxew91	46	3	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	46	4	response	response	NN
cord-015910-d9gxew91	46	5	in	in	IN
cord-015910-d9gxew91	46	6	these	these	DT
cord-015910-d9gxew91	46	7	situations	situation	NNS
cord-015910-d9gxew91	46	8	does	do	VBZ
cord-015910-d9gxew91	46	9	not	not	RB
cord-015910-d9gxew91	46	10	have	have	VB
cord-015910-d9gxew91	46	11	a	a	DT
cord-015910-d9gxew91	46	12	purposeful	purposeful	JJ
cord-015910-d9gxew91	46	13	nature	nature	NN
cord-015910-d9gxew91	46	14	and	and	CC
cord-015910-d9gxew91	46	15	contribute	contribute	VB
cord-015910-d9gxew91	46	16	to	to	IN
cord-015910-d9gxew91	46	17	the	the	DT
cord-015910-d9gxew91	46	18	disease	disease	NN
cord-015910-d9gxew91	46	19	process	process	NN
cord-015910-d9gxew91	46	20	.	.	.
cord-015910-d9gxew91	47	1	Recent	recent	JJ
cord-015910-d9gxew91	47	2	studies	study	NNS
cord-015910-d9gxew91	47	3	indicate	indicate	VBP
cord-015910-d9gxew91	47	4	that	that	IN
cord-015910-d9gxew91	47	5	low	low	JJ
cord-015910-d9gxew91	47	6	-	-	HYPH
cord-015910-d9gxew91	47	7	intensity	intensity	NN
cord-015910-d9gxew91	47	8	inflammation	inflammation	NN
cord-015910-d9gxew91	47	9	occurs	occur	VBZ
cord-015910-d9gxew91	47	10	in	in	IN
cord-015910-d9gxew91	47	11	elderly	elderly	JJ
cord-015910-d9gxew91	47	12	and	and	CC
cord-015910-d9gxew91	47	13	obese	obese	JJ
cord-015910-d9gxew91	47	14	individuals	individual	NNS
cord-015910-d9gxew91	47	15	(	(	-LRB-
cord-015910-d9gxew91	47	16	Grimble	grimble	JJ
cord-015910-d9gxew91	47	17	2002	2002	CD
cord-015910-d9gxew91	47	18	(	(	-LRB-
cord-015910-d9gxew91	47	19	Grimble	Grimble	NNP
cord-015910-d9gxew91	47	20	,	,	,
cord-015910-d9gxew91	47	21	2003	2003	CD
cord-015910-d9gxew91	47	22	.	.	.
cord-015910-d9gxew91	48	1	Thus	thus	RB
cord-015910-d9gxew91	48	2	,	,	,
cord-015910-d9gxew91	48	3	the	the	DT
cord-015910-d9gxew91	48	4	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	48	5	response	response	NN
cord-015910-d9gxew91	48	6	,	,	,
cord-015910-d9gxew91	48	7	which	which	WDT
cord-015910-d9gxew91	48	8	has	have	VBZ
cord-015910-d9gxew91	48	9	evolved	evolve	VBN
cord-015910-d9gxew91	48	10	to	to	TO
cord-015910-d9gxew91	48	11	allow	allow	VB
cord-015910-d9gxew91	48	12	humankind	humankind	NN
cord-015910-d9gxew91	48	13	to	to	TO
cord-015910-d9gxew91	48	14	survive	survive	VB
cord-015910-d9gxew91	48	15	infection	infection	NN
cord-015910-d9gxew91	48	16	and	and	CC
cord-015910-d9gxew91	48	17	injury	injury	NN
cord-015910-d9gxew91	48	18	,	,	,
cord-015910-d9gxew91	48	19	is	be	VBZ
cord-015910-d9gxew91	48	20	indiscriminate	indiscriminate	JJ
cord-015910-d9gxew91	48	21	in	in	IN
cord-015910-d9gxew91	48	22	both	both	CC
cord-015910-d9gxew91	48	23	its	-PRON-	PRP$
cord-015910-d9gxew91	48	24	triggers	trigger	NNS
cord-015910-d9gxew91	48	25	and	and	CC
cord-015910-d9gxew91	48	26	targets	target	NNS
cord-015910-d9gxew91	48	27	.	.	.
cord-015910-d9gxew91	49	1	As	as	IN
cord-015910-d9gxew91	49	2	a	a	DT
cord-015910-d9gxew91	49	3	result	result	NN
cord-015910-d9gxew91	49	4	,	,	,
cord-015910-d9gxew91	49	5	the	the	DT
cord-015910-d9gxew91	49	6	process	process	NN
cord-015910-d9gxew91	49	7	is	be	VBZ
cord-015910-d9gxew91	49	8	a	a	DT
cord-015910-d9gxew91	49	9	two	two	CD
cord-015910-d9gxew91	49	10	-	-	HYPH
cord-015910-d9gxew91	49	11	edged	edge	VBN
cord-015910-d9gxew91	49	12	sword	sword	NN
cord-015910-d9gxew91	49	13	capable	capable	JJ
cord-015910-d9gxew91	49	14	of	of	IN
cord-015910-d9gxew91	49	15	both	both	DT
cord-015910-d9gxew91	49	16	defending	defend	VBG
cord-015910-d9gxew91	49	17	and	and	CC
cord-015910-d9gxew91	49	18	damaging	damage	VBG
cord-015910-d9gxew91	49	19	its	-PRON-	PRP$
cord-015910-d9gxew91	49	20	bearer	bearer	NN
cord-015910-d9gxew91	49	21	.	.	.
cord-015910-d9gxew91	50	1	During	during	IN
cord-015910-d9gxew91	50	2	the	the	DT
cord-015910-d9gxew91	50	3	remainder	remainder	NN
cord-015910-d9gxew91	50	4	of	of	IN
cord-015910-d9gxew91	50	5	this	this	DT
cord-015910-d9gxew91	50	6	chapter	chapter	NN
cord-015910-d9gxew91	50	7	we	-PRON-	PRP
cord-015910-d9gxew91	50	8	will	will	MD
cord-015910-d9gxew91	50	9	be	be	VB
cord-015910-d9gxew91	50	10	exploring	explore	VBG
cord-015910-d9gxew91	50	11	the	the	DT
cord-015910-d9gxew91	50	12	biological	biological	JJ
cord-015910-d9gxew91	50	13	and	and	CC
cord-015910-d9gxew91	50	14	nutritional	nutritional	JJ
cord-015910-d9gxew91	50	15	factors	factor	NNS
cord-015910-d9gxew91	50	16	that	that	WDT
cord-015910-d9gxew91	50	17	determine	determine	VBP
cord-015910-d9gxew91	50	18	the	the	DT
cord-015910-d9gxew91	50	19	intensity	intensity	NN
cord-015910-d9gxew91	50	20	of	of	IN
cord-015910-d9gxew91	50	21	,	,	,
cord-015910-d9gxew91	50	22	and	and	CC
cord-015910-d9gxew91	50	23	outcome	outcome	VB
cord-015910-d9gxew91	50	24	from	from	IN
cord-015910-d9gxew91	50	25	,	,	,
cord-015910-d9gxew91	50	26	the	the	DT
cord-015910-d9gxew91	50	27	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	50	28	process	process	NN
cord-015910-d9gxew91	50	29	.	.	.
cord-015910-d9gxew91	51	1	Various	various	JJ
cord-015910-d9gxew91	51	2	components	component	NNS
cord-015910-d9gxew91	51	3	of	of	IN
cord-015910-d9gxew91	51	4	the	the	DT
cord-015910-d9gxew91	51	5	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	51	6	response	response	NN
cord-015910-d9gxew91	51	7	interact	interact	VBP
cord-015910-d9gxew91	51	8	to	to	TO
cord-015910-d9gxew91	51	9	modulate	modulate	VB
cord-015910-d9gxew91	51	10	its	-PRON-	PRP$
cord-015910-d9gxew91	51	11	intensity	intensity	NN
cord-015910-d9gxew91	51	12	.	.	.
cord-015910-d9gxew91	52	1	Predominant	predominant	JJ
cord-015910-d9gxew91	52	2	among	among	IN
cord-015910-d9gxew91	52	3	these	these	DT
cord-015910-d9gxew91	52	4	interactions	interaction	NNS
cord-015910-d9gxew91	52	5	are	be	VBP
cord-015910-d9gxew91	52	6	the	the	DT
cord-015910-d9gxew91	52	7	relative	relative	JJ
cord-015910-d9gxew91	52	8	amounts	amount	NNS
cord-015910-d9gxew91	52	9	of	of	IN
cord-015910-d9gxew91	52	10	pro	pro	JJ
cord-015910-d9gxew91	52	11	-	-	JJ
cord-015910-d9gxew91	52	12	and	and	CC
cord-015910-d9gxew91	52	13	anti	anti	JJ
cord-015910-d9gxew91	52	14	-	-	JJ
cord-015910-d9gxew91	52	15	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	52	16	cytokines	cytokine	NNS
cord-015910-d9gxew91	52	17	produced	produce	VBN
cord-015910-d9gxew91	52	18	during	during	IN
cord-015910-d9gxew91	52	19	the	the	DT
cord-015910-d9gxew91	52	20	response	response	NN
cord-015910-d9gxew91	52	21	to	to	IN
cord-015910-d9gxew91	52	22	microbes	microbe	NNS
cord-015910-d9gxew91	52	23	and	and	CC
cord-015910-d9gxew91	52	24	injury	injury	NN
cord-015910-d9gxew91	52	25	and	and	CC
cord-015910-d9gxew91	52	26	the	the	DT
cord-015910-d9gxew91	52	27	effect	effect	NN
cord-015910-d9gxew91	52	28	of	of	IN
cord-015910-d9gxew91	52	29	oxidant	oxidant	JJ
cord-015910-d9gxew91	52	30	molecules	molecule	NNS
cord-015910-d9gxew91	52	31	on	on	IN
cord-015910-d9gxew91	52	32	cytokine	cytokine	NN
cord-015910-d9gxew91	52	33	production	production	NN
cord-015910-d9gxew91	52	34	.	.	.
cord-015910-d9gxew91	53	1	Early	early	JJ
cord-015910-d9gxew91	53	2	work	work	NN
cord-015910-d9gxew91	53	3	on	on	IN
cord-015910-d9gxew91	53	4	cytokines	cytokine	NNS
cord-015910-d9gxew91	53	5	and	and	CC
cord-015910-d9gxew91	53	6	the	the	DT
cord-015910-d9gxew91	53	7	response	response	NN
cord-015910-d9gxew91	53	8	to	to	IN
cord-015910-d9gxew91	53	9	infection	infection	NN
cord-015910-d9gxew91	53	10	linked	link	VBD
cord-015910-d9gxew91	53	11	excessive	excessive	JJ
cord-015910-d9gxew91	53	12	pro	pro	JJ
cord-015910-d9gxew91	53	13	-	-	JJ
cord-015910-d9gxew91	53	14	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	53	15	cytokine	cytokine	NN
cord-015910-d9gxew91	53	16	production	production	NN
cord-015910-d9gxew91	53	17	with	with	IN
cord-015910-d9gxew91	53	18	increased	increase	VBN
cord-015910-d9gxew91	53	19	morbidity	morbidity	NN
cord-015910-d9gxew91	53	20	and	and	CC
cord-015910-d9gxew91	53	21	mortality	mortality	NN
cord-015910-d9gxew91	53	22	in	in	IN
cord-015910-d9gxew91	53	23	a	a	DT
cord-015910-d9gxew91	53	24	wide	wide	JJ
cord-015910-d9gxew91	53	25	range	range	NN
cord-015910-d9gxew91	53	26	of	of	IN
cord-015910-d9gxew91	53	27	conditions	condition	NNS
cord-015910-d9gxew91	53	28	,	,	,
cord-015910-d9gxew91	53	29	such	such	JJ
cord-015910-d9gxew91	53	30	as	as	IN
cord-015910-d9gxew91	53	31	malaria	malaria	NN
cord-015910-d9gxew91	53	32	,	,	,
cord-015910-d9gxew91	53	33	meningitis	meningitis	NN
cord-015910-d9gxew91	53	34	,	,	,
cord-015910-d9gxew91	53	35	and	and	CC
cord-015910-d9gxew91	53	36	sepsis	sepsis	NN
cord-015910-d9gxew91	53	37	.	.	.
cord-015910-d9gxew91	54	1	However	however	RB
cord-015910-d9gxew91	54	2	,	,	,
cord-015910-d9gxew91	54	3	research	research	NN
cord-015910-d9gxew91	54	4	in	in	IN
cord-015910-d9gxew91	54	5	the	the	DT
cord-015910-d9gxew91	54	6	last	last	JJ
cord-015910-d9gxew91	54	7	5	5	CD
cord-015910-d9gxew91	54	8	yr	yr	NN
cord-015910-d9gxew91	54	9	has	have	VBZ
cord-015910-d9gxew91	54	10	shown	show	VBN
cord-015910-d9gxew91	54	11	that	that	IN
cord-015910-d9gxew91	54	12	the	the	DT
cord-015910-d9gxew91	54	13	balance	balance	NN
cord-015910-d9gxew91	54	14	in	in	IN
cord-015910-d9gxew91	54	15	production	production	NN
cord-015910-d9gxew91	54	16	between	between	IN
cord-015910-d9gxew91	54	17	pro	pro	JJ
cord-015910-d9gxew91	54	18	-	-	JJ
cord-015910-d9gxew91	54	19	and	and	CC
cord-015910-d9gxew91	54	20	anti	anti	JJ
cord-015910-d9gxew91	54	21	-	-	JJ
cord-015910-d9gxew91	54	22	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	54	23	cytokines	cytokine	NNS
cord-015910-d9gxew91	54	24	has	have	VBZ
cord-015910-d9gxew91	54	25	a	a	DT
cord-015910-d9gxew91	54	26	more	more	RBR
cord-015910-d9gxew91	54	27	direct	direct	JJ
cord-015910-d9gxew91	54	28	bearing	bearing	NN
cord-015910-d9gxew91	54	29	on	on	IN
cord-015910-d9gxew91	54	30	the	the	DT
cord-015910-d9gxew91	54	31	outcome	outcome	NN
cord-015910-d9gxew91	54	32	of	of	IN
cord-015910-d9gxew91	54	33	infection	infection	NN
cord-015910-d9gxew91	54	34	and	and	CC
cord-015910-d9gxew91	54	35	injury	injury	NN
cord-015910-d9gxew91	54	36	.	.	.
cord-015910-d9gxew91	55	1	For	for	IN
cord-015910-d9gxew91	55	2	example	example	NN
cord-015910-d9gxew91	55	3	,	,	,
cord-015910-d9gxew91	55	4	in	in	IN
cord-015910-d9gxew91	55	5	sepsis	sepsis	NN
cord-015910-d9gxew91	55	6	,	,	,
cord-015910-d9gxew91	55	7	plasma	plasma	NN
cord-015910-d9gxew91	55	8	IL-6	IL-6	NNP
cord-015910-d9gxew91	55	9	concentrations	concentration	NNS
cord-015910-d9gxew91	55	10	were	be	VBD
cord-015910-d9gxew91	55	11	higher	high	JJR
cord-015910-d9gxew91	55	12	and	and	CC
cord-015910-d9gxew91	55	13	IL-10	IL-10	NNP
cord-015910-d9gxew91	55	14	concentrations	concentration	NNS
cord-015910-d9gxew91	55	15	were	be	VBD
cord-015910-d9gxew91	55	16	lower	low	JJR
cord-015910-d9gxew91	55	17	in	in	IN
cord-015910-d9gxew91	55	18	patients	patient	NNS
cord-015910-d9gxew91	55	19	who	who	WP
cord-015910-d9gxew91	55	20	died	die	VBD
cord-015910-d9gxew91	55	21	than	than	IN
cord-015910-d9gxew91	55	22	in	in	IN
cord-015910-d9gxew91	55	23	those	those	DT
cord-015910-d9gxew91	55	24	who	who	WP
cord-015910-d9gxew91	55	25	survived	survive	VBD
cord-015910-d9gxew91	55	26	(	(	-LRB-
cord-015910-d9gxew91	55	27	Arnalich	Arnalich	NNP
cord-015910-d9gxew91	55	28	et	et	NNP
cord-015910-d9gxew91	55	29	al	al	NNP
cord-015910-d9gxew91	55	30	.	.	NNP
cord-015910-d9gxew91	55	31	,	,	,
cord-015910-d9gxew91	55	32	2000	2000	CD
cord-015910-d9gxew91	55	33	;	;	:
cord-015910-d9gxew91	55	34	Taniguchi	Taniguchi	NNP
cord-015910-d9gxew91	55	35	et	et	NNP
cord-015910-d9gxew91	55	36	al	al	NNP
cord-015910-d9gxew91	55	37	.	.	NNP
cord-015910-d9gxew91	55	38	,	,	,
cord-015910-d9gxew91	55	39	1999	1999	CD
cord-015910-d9gxew91	55	40	)	)	-RRB-
cord-015910-d9gxew91	55	41	.	.	.
cord-015910-d9gxew91	56	1	A	a	DT
cord-015910-d9gxew91	56	2	survey	survey	NN
cord-015910-d9gxew91	56	3	of	of	IN
cord-015910-d9gxew91	56	4	over	over	IN
cord-015910-d9gxew91	56	5	400	400	CD
cord-015910-d9gxew91	56	6	patients	patient	NNS
cord-015910-d9gxew91	56	7	admitted	admit	VBN
cord-015910-d9gxew91	56	8	to	to	IN
cord-015910-d9gxew91	56	9	hospital	hospital	NN
cord-015910-d9gxew91	56	10	in	in	IN
cord-015910-d9gxew91	56	11	the	the	DT
cord-015910-d9gxew91	56	12	Netherlands	Netherlands	NNP
cord-015910-d9gxew91	56	13	with	with	IN
cord-015910-d9gxew91	56	14	fever	fever	NN
cord-015910-d9gxew91	56	15	showed	show	VBD
cord-015910-d9gxew91	56	16	that	that	IN
cord-015910-d9gxew91	56	17	,	,	,
cord-015910-d9gxew91	56	18	independently	independently	RB
cord-015910-d9gxew91	56	19	of	of	IN
cord-015910-d9gxew91	56	20	how	how	WRB
cord-015910-d9gxew91	56	21	the	the	DT
cord-015910-d9gxew91	56	22	patients	patient	NNS
cord-015910-d9gxew91	56	23	were	be	VBD
cord-015910-d9gxew91	56	24	clinically	clinically	RB
cord-015910-d9gxew91	56	25	classified	classified	JJ
cord-015910-d9gxew91	56	26	(	(	-LRB-
cord-015910-d9gxew91	56	27	positive	positive	JJ
cord-015910-d9gxew91	56	28	blood	blood	NN
cord-015910-d9gxew91	56	29	cultures	culture	NNS
cord-015910-d9gxew91	56	30	,	,	,
cord-015910-d9gxew91	56	31	presence	presence	NN
cord-015910-d9gxew91	56	32	of	of	IN
cord-015910-d9gxew91	56	33	endotoxin	endotoxin	NN
cord-015910-d9gxew91	56	34	)	)	-RRB-
cord-015910-d9gxew91	56	35	,	,	,
cord-015910-d9gxew91	56	36	those	those	DT
cord-015910-d9gxew91	56	37	who	who	WP
cord-015910-d9gxew91	56	38	subsequently	subsequently	RB
cord-015910-d9gxew91	56	39	died	die	VBD
cord-015910-d9gxew91	56	40	had	have	VBD
cord-015910-d9gxew91	56	41	a	a	DT
cord-015910-d9gxew91	56	42	higher	high	JJR
cord-015910-d9gxew91	56	43	plasma	plasma	NN
cord-015910-d9gxew91	56	44	IL-10	IL-10	NNP
cord-015910-d9gxew91	56	45	:	:	:
cord-015910-d9gxew91	56	46	TNF	TNF	NNP
cord-015910-d9gxew91	56	47	-	-	HYPH
cord-015910-d9gxew91	56	48	o~	o~	CD
cord-015910-d9gxew91	56	49	ratio	ratio	NN
cord-015910-d9gxew91	56	50	than	than	IN
cord-015910-d9gxew91	56	51	patients	patient	NNS
cord-015910-d9gxew91	56	52	who	who	WP
cord-015910-d9gxew91	56	53	survived	survive	VBD
cord-015910-d9gxew91	56	54	(	(	-LRB-
cord-015910-d9gxew91	56	55	Van	Van	NNP
cord-015910-d9gxew91	56	56	Dissell	Dissell	NNP
cord-015910-d9gxew91	56	57	,	,	,
cord-015910-d9gxew91	56	58	van	van	NNP
cord-015910-d9gxew91	56	59	Langervelde	Langervelde	NNP
cord-015910-d9gxew91	56	60	,	,	,
cord-015910-d9gxew91	56	61	Westendorp	Westendorp	NNP
cord-015910-d9gxew91	56	62	,	,	,
cord-015910-d9gxew91	56	63	Kwappenberg	Kwappenberg	NNP
cord-015910-d9gxew91	56	64	,	,	,
cord-015910-d9gxew91	56	65	&	&	CC
cord-015910-d9gxew91	56	66	Frolich	Frolich	NNP
cord-015910-d9gxew91	56	67	,	,	,
cord-015910-d9gxew91	56	68	1998	1998	CD
cord-015910-d9gxew91	56	69	)	)	-RRB-
cord-015910-d9gxew91	56	70	.	.	.
cord-015910-d9gxew91	57	1	Powerful	powerful	JJ
cord-015910-d9gxew91	57	2	oxidant	oxidant	JJ
cord-015910-d9gxew91	57	3	molecules	molecule	NNS
cord-015910-d9gxew91	57	4	(	(	-LRB-
cord-015910-d9gxew91	57	5	e.g.	e.g.	RB
cord-015910-d9gxew91	57	6	,	,	,
cord-015910-d9gxew91	57	7	superoxide	superoxide	NN
cord-015910-d9gxew91	57	8	,	,	,
cord-015910-d9gxew91	57	9	hydrogen	hydrogen	NN
cord-015910-d9gxew91	57	10	peroxide	peroxide	NN
cord-015910-d9gxew91	57	11	,	,	,
cord-015910-d9gxew91	57	12	hypochlorous	hypochlorous	JJ
cord-015910-d9gxew91	57	13	acid	acid	NN
cord-015910-d9gxew91	57	14	)	)	-RRB-
cord-015910-d9gxew91	57	15	are	be	VBP
cord-015910-d9gxew91	57	16	produced	produce	VBN
cord-015910-d9gxew91	57	17	as	as	IN
cord-015910-d9gxew91	57	18	part	part	NN
cord-015910-d9gxew91	57	19	of	of	IN
cord-015910-d9gxew91	57	20	the	the	DT
cord-015910-d9gxew91	57	21	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	57	22	response	response	NN
cord-015910-d9gxew91	57	23	.	.	.
cord-015910-d9gxew91	58	1	Their	-PRON-	PRP$
cord-015910-d9gxew91	58	2	biological	biological	JJ
cord-015910-d9gxew91	58	3	purpose	purpose	NN
cord-015910-d9gxew91	58	4	is	be	VBZ
cord-015910-d9gxew91	58	5	to	to	TO
cord-015910-d9gxew91	58	6	destroy	destroy	VB
cord-015910-d9gxew91	58	7	invading	invade	VBG
cord-015910-d9gxew91	58	8	microbes	microbe	NNS
cord-015910-d9gxew91	58	9	.	.	.
cord-015910-d9gxew91	59	1	However	however	RB
cord-015910-d9gxew91	59	2	,	,	,
cord-015910-d9gxew91	59	3	these	these	DT
cord-015910-d9gxew91	59	4	molecules	molecule	NNS
cord-015910-d9gxew91	59	5	also	also	RB
cord-015910-d9gxew91	59	6	have	have	VBP
cord-015910-d9gxew91	59	7	the	the	DT
cord-015910-d9gxew91	59	8	capacity	capacity	NN
cord-015910-d9gxew91	59	9	to	to	TO
cord-015910-d9gxew91	59	10	damage	damage	VB
cord-015910-d9gxew91	59	11	host	host	NN
cord-015910-d9gxew91	59	12	tissues	tissue	NNS
cord-015910-d9gxew91	59	13	and	and	CC
cord-015910-d9gxew91	59	14	to	to	TO
cord-015910-d9gxew91	59	15	increase	increase	VB
cord-015910-d9gxew91	59	16	the	the	DT
cord-015910-d9gxew91	59	17	intensity	intensity	NN
cord-015910-d9gxew91	59	18	of	of	IN
cord-015910-d9gxew91	59	19	the	the	DT
cord-015910-d9gxew91	59	20	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	59	21	response	response	NN
cord-015910-d9gxew91	59	22	.	.	.
cord-015910-d9gxew91	60	1	Clearly	clearly	RB
cord-015910-d9gxew91	60	2	both	both	DT
cord-015910-d9gxew91	60	3	of	of	IN
cord-015910-d9gxew91	60	4	these	these	DT
cord-015910-d9gxew91	60	5	biological	biological	JJ
cord-015910-d9gxew91	60	6	events	event	NNS
cord-015910-d9gxew91	60	7	can	can	MD
cord-015910-d9gxew91	60	8	have	have	VB
cord-015910-d9gxew91	60	9	adverse	adverse	JJ
cord-015910-d9gxew91	60	10	effects	effect	NNS
cord-015910-d9gxew91	60	11	upon	upon	IN
cord-015910-d9gxew91	60	12	the	the	DT
cord-015910-d9gxew91	60	13	host	host	NN
cord-015910-d9gxew91	60	14	.	.	.
cord-015910-d9gxew91	61	1	The	the	DT
cord-015910-d9gxew91	61	2	oxidant	oxidant	JJ
cord-015910-d9gxew91	61	3	molecules	molecule	NNS
cord-015910-d9gxew91	61	4	activate	activate	VBP
cord-015910-d9gxew91	61	5	at	at	RB
cord-015910-d9gxew91	61	6	least	least	RBS
cord-015910-d9gxew91	61	7	two	two	CD
cord-015910-d9gxew91	61	8	important	important	JJ
cord-015910-d9gxew91	61	9	families	family	NNS
cord-015910-d9gxew91	61	10	of	of	IN
cord-015910-d9gxew91	61	11	proteins	protein	NNS
cord-015910-d9gxew91	61	12	in	in	IN
cord-015910-d9gxew91	61	13	the	the	DT
cord-015910-d9gxew91	61	14	host	host	NN
cord-015910-d9gxew91	61	15	that	that	WDT
cord-015910-d9gxew91	61	16	are	be	VBP
cord-015910-d9gxew91	61	17	sensitive	sensitive	JJ
cord-015910-d9gxew91	61	18	to	to	IN
cord-015910-d9gxew91	61	19	changes	change	NNS
cord-015910-d9gxew91	61	20	in	in	IN
cord-015910-d9gxew91	61	21	cellular	cellular	JJ
cord-015910-d9gxew91	61	22	redox	redox	NN
cord-015910-d9gxew91	61	23	state	state	NN
cord-015910-d9gxew91	61	24	.	.	.
cord-015910-d9gxew91	62	1	The	the	DT
cord-015910-d9gxew91	62	2	families	family	NNS
cord-015910-d9gxew91	62	3	are	be	VBP
cord-015910-d9gxew91	62	4	nuclear	nuclear	JJ
cord-015910-d9gxew91	62	5	transcription	transcription	NN
cord-015910-d9gxew91	62	6	factor	factor	NN
cord-015910-d9gxew91	62	7	K	K	NNP
cord-015910-d9gxew91	62	8	B	B	NNP
cord-015910-d9gxew91	62	9	(	(	-LRB-
cord-015910-d9gxew91	62	10	NF	NF	NNP
cord-015910-d9gxew91	62	11	-	-	HYPH
cord-015910-d9gxew91	62	12	rd3	rd3	NNP
cord-015910-d9gxew91	62	13	)	)	-RRB-
cord-015910-d9gxew91	62	14	and	and	CC
cord-015910-d9gxew91	62	15	activator	activator	NN
cord-015910-d9gxew91	62	16	protein	protein	NN
cord-015910-d9gxew91	62	17	1	1	CD
cord-015910-d9gxew91	62	18	(	(	-LRB-
cord-015910-d9gxew91	62	19	AP1	AP1	NNP
cord-015910-d9gxew91	62	20	)	)	-RRB-
cord-015910-d9gxew91	62	21	.	.	.
cord-015910-d9gxew91	63	1	These	these	DT
cord-015910-d9gxew91	63	2	transcription	transcription	NN
cord-015910-d9gxew91	63	3	factors	factor	NNS
cord-015910-d9gxew91	63	4	act	act	VBP
cord-015910-d9gxew91	63	5	as	as	IN
cord-015910-d9gxew91	63	6	"	"	``
cord-015910-d9gxew91	63	7	control	control	NN
cord-015910-d9gxew91	63	8	switches	switch	NNS
cord-015910-d9gxew91	63	9	"	"	''
cord-015910-d9gxew91	63	10	for	for	IN
cord-015910-d9gxew91	63	11	biological	biological	JJ
cord-015910-d9gxew91	63	12	processes	process	NNS
cord-015910-d9gxew91	63	13	,	,	,
cord-015910-d9gxew91	63	14	not	not	RB
cord-015910-d9gxew91	63	15	all	all	DT
cord-015910-d9gxew91	63	16	of	of	IN
cord-015910-d9gxew91	63	17	which	which	WDT
cord-015910-d9gxew91	63	18	are	be	VBP
cord-015910-d9gxew91	63	19	of	of	IN
cord-015910-d9gxew91	63	20	advantage	advantage	NN
cord-015910-d9gxew91	63	21	to	to	IN
cord-015910-d9gxew91	63	22	the	the	DT
cord-015910-d9gxew91	63	23	individual	individual	NN
cord-015910-d9gxew91	63	24	.	.	.
cord-015910-d9gxew91	64	1	NF	NF	NNP
cord-015910-d9gxew91	64	2	-	-	HYPH
cord-015910-d9gxew91	64	3	rd3	rd3	NNP
cord-015910-d9gxew91	64	4	is	be	VBZ
cord-015910-d9gxew91	64	5	present	present	JJ
cord-015910-d9gxew91	64	6	in	in	IN
cord-015910-d9gxew91	64	7	the	the	DT
cord-015910-d9gxew91	64	8	cytosol	cytosol	NN
cord-015910-d9gxew91	64	9	in	in	IN
cord-015910-d9gxew91	64	10	an	an	DT
cord-015910-d9gxew91	64	11	inactive	inactive	JJ
cord-015910-d9gxew91	64	12	form	form	NN
cord-015910-d9gxew91	64	13	,	,	,
cord-015910-d9gxew91	64	14	by	by	IN
cord-015910-d9gxew91	64	15	virtue	virtue	NN
cord-015910-d9gxew91	64	16	of	of	IN
cord-015910-d9gxew91	64	17	being	be	VBG
cord-015910-d9gxew91	64	18	bound	bind	VBN
cord-015910-d9gxew91	64	19	to	to	IN
cord-015910-d9gxew91	64	20	an	an	DT
cord-015910-d9gxew91	64	21	inhibitory	inhibitory	JJ
cord-015910-d9gxew91	64	22	unit	unit	NN
cord-015910-d9gxew91	64	23	I	I	NNP
cord-015910-d9gxew91	64	24	-	-	HYPH
cord-015910-d9gxew91	64	25	r	r	NNP
cord-015910-d9gxew91	64	26	,	,	,
cord-015910-d9gxew91	64	27	B.	B.	NNP
cord-015910-d9gxew91	64	28	Phosphorylation	Phosphorylation	NNP
cord-015910-d9gxew91	64	29	and	and	CC
cord-015910-d9gxew91	64	30	dissociation	dissociation	NN
cord-015910-d9gxew91	64	31	of	of	IN
cord-015910-d9gxew91	64	32	I	I	NNP
cord-015910-d9gxew91	64	33	-	-	HYPH
cord-015910-d9gxew91	64	34	r	r	NNP
cord-015910-d9gxew91	64	35	,	,	,
cord-015910-d9gxew91	64	36	B	B	NNP
cord-015910-d9gxew91	64	37	renders	render	VBZ
cord-015910-d9gxew91	64	38	the	the	DT
cord-015910-d9gxew91	64	39	remaining	remain	VBG
cord-015910-d9gxew91	64	40	NF-~cB	nf-~cb	JJ
cord-015910-d9gxew91	64	41	dimer	dimer	NN
cord-015910-d9gxew91	64	42	active	active	JJ
cord-015910-d9gxew91	64	43	.	.	.
cord-015910-d9gxew91	65	1	The	the	DT
cord-015910-d9gxew91	65	2	dissociated	dissociated	JJ
cord-015910-d9gxew91	65	3	I	I	NNP
cord-015910-d9gxew91	65	4	-	-	HYPH
cord-015910-d9gxew91	65	5	rd3	rd3	NNP
cord-015910-d9gxew91	65	6	is	be	VBZ
cord-015910-d9gxew91	65	7	degraded	degrade	VBN
cord-015910-d9gxew91	65	8	,	,	,
cord-015910-d9gxew91	65	9	and	and	CC
cord-015910-d9gxew91	65	10	the	the	DT
cord-015910-d9gxew91	65	11	active	active	JJ
cord-015910-d9gxew91	65	12	NF	nf	NN
cord-015910-d9gxew91	65	13	-	-	HYPH
cord-015910-d9gxew91	65	14	r	r	NN
cord-015910-d9gxew91	65	15	,	,	,
cord-015910-d9gxew91	65	16	B	B	NNP
cord-015910-d9gxew91	65	17	is	be	VBZ
cord-015910-d9gxew91	65	18	translocated	translocate	VBN
cord-015910-d9gxew91	65	19	to	to	IN
cord-015910-d9gxew91	65	20	the	the	DT
cord-015910-d9gxew91	65	21	nucleus	nucleus	NN
cord-015910-d9gxew91	65	22	,	,	,
cord-015910-d9gxew91	65	23	where	where	WRB
cord-015910-d9gxew91	65	24	it	-PRON-	PRP
cord-015910-d9gxew91	65	25	binds	bind	VBZ
cord-015910-d9gxew91	65	26	to	to	IN
cord-015910-d9gxew91	65	27	response	response	NN
cord-015910-d9gxew91	65	28	elements	element	NNS
cord-015910-d9gxew91	65	29	in	in	IN
cord-015910-d9gxew91	65	30	the	the	DT
cord-015910-d9gxew91	65	31	promoter	promoter	NN
cord-015910-d9gxew91	65	32	regions	region	NNS
cord-015910-d9gxew91	65	33	of	of	IN
cord-015910-d9gxew91	65	34	genes	gene	NNS
cord-015910-d9gxew91	65	35	.	.	.
cord-015910-d9gxew91	66	1	A	a	DT
cord-015910-d9gxew91	66	2	similar	similar	JJ
cord-015910-d9gxew91	66	3	translocation	translocation	NN
cord-015910-d9gxew91	66	4	of	of	IN
cord-015910-d9gxew91	66	5	AP1	AP1	NNP
cord-015910-d9gxew91	66	6	,	,	,
cord-015910-d9gxew91	66	7	a	a	DT
cord-015910-d9gxew91	66	8	transcription	transcription	NN
cord-015910-d9gxew91	66	9	factor	factor	NN
cord-015910-d9gxew91	66	10	composed	compose	VBN
cord-015910-d9gxew91	66	11	of	of	IN
cord-015910-d9gxew91	66	12	the	the	DT
cord-015910-d9gxew91	66	13	protooncogenes	protooncogenes	NNP
cord-015910-d9gxew91	66	14	c	c	NNP
cord-015910-d9gxew91	66	15	-	-	HYPH
cord-015910-d9gxew91	66	16	fos	fos	NNP
cord-015910-d9gxew91	66	17	and	and	CC
cord-015910-d9gxew91	66	18	c	c	NNP
cord-015910-d9gxew91	66	19	-	-	:
cord-015910-d9gxew91	66	20	jun	jun	NNP
cord-015910-d9gxew91	66	21	,	,	,
cord-015910-d9gxew91	66	22	from	from	IN
cord-015910-d9gxew91	66	23	cytosol	cytosol	NN
cord-015910-d9gxew91	66	24	to	to	IN
cord-015910-d9gxew91	66	25	nucleus	nucleus	NN
cord-015910-d9gxew91	66	26	,	,	,
cord-015910-d9gxew91	66	27	also	also	RB
cord-015910-d9gxew91	66	28	occurs	occur	VBZ
cord-015910-d9gxew91	66	29	in	in	IN
cord-015910-d9gxew91	66	30	the	the	DT
cord-015910-d9gxew91	66	31	presence	presence	NN
cord-015910-d9gxew91	66	32	of	of	IN
cord-015910-d9gxew91	66	33	oxidant	oxidant	JJ
cord-015910-d9gxew91	66	34	stress	stress	NN
cord-015910-d9gxew91	66	35	.	.	.
cord-015910-d9gxew91	67	1	Binding	bind	VBG
cord-015910-d9gxew91	67	2	of	of	IN
cord-015910-d9gxew91	67	3	the	the	DT
cord-015910-d9gxew91	67	4	transcription	transcription	NN
cord-015910-d9gxew91	67	5	factors	factor	NNS
cord-015910-d9gxew91	67	6	is	be	VBZ
cord-015910-d9gxew91	67	7	implicated	implicate	VBN
cord-015910-d9gxew91	67	8	in	in	IN
cord-015910-d9gxew91	67	9	activation	activation	NN
cord-015910-d9gxew91	67	10	of	of	IN
cord-015910-d9gxew91	67	11	a	a	DT
cord-015910-d9gxew91	67	12	wide	wide	JJ
cord-015910-d9gxew91	67	13	range	range	NN
cord-015910-d9gxew91	67	14	of	of	IN
cord-015910-d9gxew91	67	15	genes	gene	NNS
cord-015910-d9gxew91	67	16	associated	associate	VBN
cord-015910-d9gxew91	67	17	with	with	IN
cord-015910-d9gxew91	67	18	inflammation	inflammation	NN
cord-015910-d9gxew91	67	19	and	and	CC
cord-015910-d9gxew91	67	20	the	the	DT
cord-015910-d9gxew91	67	21	immune	immune	JJ
cord-015910-d9gxew91	67	22	response	response	NN
cord-015910-d9gxew91	67	23	,	,	,
cord-015910-d9gxew91	67	24	including	include	VBG
cord-015910-d9gxew91	67	25	those	those	DT
cord-015910-d9gxew91	67	26	encoding	encode	VBG
cord-015910-d9gxew91	67	27	cytokines	cytokine	NNS
cord-015910-d9gxew91	67	28	,	,	,
cord-015910-d9gxew91	67	29	cytokine	cytokine	NN
cord-015910-d9gxew91	67	30	receptors	receptor	NNS
cord-015910-d9gxew91	67	31	,	,	,
cord-015910-d9gxew91	67	32	cell	cell	NN
cord-015910-d9gxew91	67	33	adhesion	adhesion	NN
cord-015910-d9gxew91	67	34	molecules	molecule	NNS
cord-015910-d9gxew91	67	35	,	,	,
cord-015910-d9gxew91	67	36	acute	acute	JJ
cord-015910-d9gxew91	67	37	-	-	HYPH
cord-015910-d9gxew91	67	38	phase	phase	NN
cord-015910-d9gxew91	67	39	proteins	protein	NNS
cord-015910-d9gxew91	67	40	,	,	,
cord-015910-d9gxew91	67	41	and	and	CC
cord-015910-d9gxew91	67	42	growth	growth	NN
cord-015910-d9gxew91	67	43	factors	factor	NNS
cord-015910-d9gxew91	68	1	(	(	-LRB-
cord-015910-d9gxew91	68	2	Schreck	Schreck	NNP
cord-015910-d9gxew91	68	3	,	,	,
cord-015910-d9gxew91	68	4	Rieber	Rieber	NNP
cord-015910-d9gxew91	68	5	,	,	,
cord-015910-d9gxew91	68	6	&	&	CC
cord-015910-d9gxew91	68	7	Baeurerle	Baeurerle	NNP
cord-015910-d9gxew91	68	8	,	,	,
cord-015910-d9gxew91	68	9	1991	1991	CD
cord-015910-d9gxew91	68	10	)	)	-RRB-
cord-015910-d9gxew91	68	11	(	(	-LRB-
cord-015910-d9gxew91	68	12	Fig	Fig	NNP
cord-015910-d9gxew91	68	13	.	.	NNP
cord-015910-d9gxew91	68	14	4	4	CD
cord-015910-d9gxew91	68	15	)	)	-RRB-
cord-015910-d9gxew91	68	16	.	.	.
cord-015910-d9gxew91	69	1	Activation	activation	NN
cord-015910-d9gxew91	69	2	of	of	IN
cord-015910-d9gxew91	69	3	NF	NF	NNP
cord-015910-d9gxew91	69	4	-	-	HYPH
cord-015910-d9gxew91	69	5	rd3	rd3	NNP
cord-015910-d9gxew91	69	6	can	can	MD
cord-015910-d9gxew91	69	7	be	be	VB
cord-015910-d9gxew91	69	8	brought	bring	VBN
cord-015910-d9gxew91	69	9	about	about	RP
cord-015910-d9gxew91	69	10	by	by	IN
cord-015910-d9gxew91	69	11	a	a	DT
cord-015910-d9gxew91	69	12	wide	wide	JJ
cord-015910-d9gxew91	69	13	range	range	NN
cord-015910-d9gxew91	69	14	of	of	IN
cord-015910-d9gxew91	69	15	stimuli	stimulus	NNS
cord-015910-d9gxew91	69	16	including	include	VBG
cord-015910-d9gxew91	69	17	pro	pro	JJ
cord-015910-d9gxew91	69	18	-	-	JJ
cord-015910-d9gxew91	69	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	69	20	cytokines	cytokine	NNS
cord-015910-d9gxew91	69	21	,	,	,
cord-015910-d9gxew91	69	22	hydrogen	hydrogen	NN
cord-015910-d9gxew91	69	23	peroxide	peroxide	NN
cord-015910-d9gxew91	69	24	,	,	,
cord-015910-d9gxew91	69	25	mitogens	mitogens	NNP
cord-015910-d9gxew91	69	26	,	,	,
cord-015910-d9gxew91	69	27	bacteria	bacteria	NNS
cord-015910-d9gxew91	69	28	and	and	CC
cord-015910-d9gxew91	69	29	viruses	virus	NNS
cord-015910-d9gxew91	69	30	and	and	CC
cord-015910-d9gxew91	69	31	their	-PRON-	PRP$
cord-015910-d9gxew91	69	32	related	related	JJ
cord-015910-d9gxew91	69	33	products	product	NNS
cord-015910-d9gxew91	69	34	,	,	,
cord-015910-d9gxew91	69	35	and	and	CC
cord-015910-d9gxew91	69	36	ultraviolet	ultraviolet	NN
cord-015910-d9gxew91	69	37	(	(	-LRB-
cord-015910-d9gxew91	69	38	UV	uv	NN
cord-015910-d9gxew91	69	39	)	)	-RRB-
cord-015910-d9gxew91	69	40	and	and	CC
cord-015910-d9gxew91	69	41	ionizing	ionize	VBG
cord-015910-d9gxew91	69	42	radiations	radiation	NNS
cord-015910-d9gxew91	69	43	.	.	.
cord-015910-d9gxew91	70	1	The	the	DT
cord-015910-d9gxew91	70	2	extent	extent	NN
cord-015910-d9gxew91	70	3	of	of	IN
cord-015910-d9gxew91	70	4	activation	activation	NN
cord-015910-d9gxew91	70	5	of	of	IN
cord-015910-d9gxew91	70	6	NF	NF	NNP
cord-015910-d9gxew91	70	7	-	-	HYPH
cord-015910-d9gxew91	70	8	rd3	rd3	NNP
cord-015910-d9gxew91	70	9	will	will	MD
cord-015910-d9gxew91	70	10	depend	depend	VB
cord-015910-d9gxew91	70	11	in	in	IN
cord-015910-d9gxew91	70	12	part	part	NN
cord-015910-d9gxew91	70	13	upon	upon	IN
cord-015910-d9gxew91	70	14	the	the	DT
cord-015910-d9gxew91	70	15	strength	strength	NN
cord-015910-d9gxew91	70	16	and	and	CC
cord-015910-d9gxew91	70	17	efficiency	efficiency	NN
cord-015910-d9gxew91	70	18	of	of	IN
cord-015910-d9gxew91	70	19	the	the	DT
cord-015910-d9gxew91	70	20	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	70	21	defenses	defense	NNS
cord-015910-d9gxew91	70	22	of	of	IN
cord-015910-d9gxew91	70	23	the	the	DT
cord-015910-d9gxew91	70	24	body	body	NN
cord-015910-d9gxew91	70	25	.	.	.
cord-015910-d9gxew91	71	1	These	these	DT
cord-015910-d9gxew91	71	2	comprise	comprise	VBP
cord-015910-d9gxew91	71	3	endogenous	endogenous	JJ
cord-015910-d9gxew91	71	4	components	component	NNS
cord-015910-d9gxew91	71	5	such	such	JJ
cord-015910-d9gxew91	71	6	as	as	IN
cord-015910-d9gxew91	71	7	glutathione	glutathione	NN
cord-015910-d9gxew91	71	8	(	(	-LRB-
cord-015910-d9gxew91	71	9	GSH	GSH	NNP
cord-015910-d9gxew91	71	10	)	)	-RRB-
cord-015910-d9gxew91	71	11	and	and	CC
cord-015910-d9gxew91	71	12	enzymatic	enzymatic	JJ
cord-015910-d9gxew91	71	13	components	component	NNS
cord-015910-d9gxew91	71	14	of	of	IN
cord-015910-d9gxew91	71	15	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	71	16	defenses	defense	NNS
cord-015910-d9gxew91	71	17	,	,	,
cord-015910-d9gxew91	71	18	such	such	JJ
cord-015910-d9gxew91	71	19	as	as	IN
cord-015910-d9gxew91	71	20	catalase	catalase	NN
cord-015910-d9gxew91	71	21	,	,	,
cord-015910-d9gxew91	71	22	superoxide	superoxide	NN
cord-015910-d9gxew91	71	23	dismutase	dismutase	NN
cord-015910-d9gxew91	71	24	(	(	-LRB-
cord-015910-d9gxew91	71	25	SOD	SOD	NNP
cord-015910-d9gxew91	71	26	)	)	-RRB-
cord-015910-d9gxew91	71	27	,	,	,
cord-015910-d9gxew91	71	28	and	and	CC
cord-015910-d9gxew91	71	29	GSH	GSH	NNP
cord-015910-d9gxew91	71	30	peroxidase	peroxidase	NN
cord-015910-d9gxew91	71	31	,	,	,
cord-015910-d9gxew91	71	32	and	and	CC
cord-015910-d9gxew91	71	33	dietary	dietary	JJ
cord-015910-d9gxew91	71	34	components	component	NNS
cord-015910-d9gxew91	71	35	that	that	WDT
cord-015910-d9gxew91	71	36	have	have	VBP
cord-015910-d9gxew91	71	37	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	71	38	properties	property	NNS
cord-015910-d9gxew91	71	39	(	(	-LRB-
cord-015910-d9gxew91	71	40	e.g.	e.g.	RB
cord-015910-d9gxew91	71	41	,	,	,
cord-015910-d9gxew91	71	42	vitamins	vitamin	NNS
cord-015910-d9gxew91	71	43	C	c	NN
cord-015910-d9gxew91	71	44	and	and	CC
cord-015910-d9gxew91	71	45	E	E	NNP
cord-015910-d9gxew91	71	46	and	and	CC
cord-015910-d9gxew91	71	47	polyphenolic	polyphenolic	JJ
cord-015910-d9gxew91	71	48	compounds	compound	NNS
cord-015910-d9gxew91	71	49	)	)	-RRB-
cord-015910-d9gxew91	71	50	.	.	.
cord-015910-d9gxew91	72	1	The	the	DT
cord-015910-d9gxew91	72	2	influence	influence	NN
cord-015910-d9gxew91	72	3	of	of	IN
cord-015910-d9gxew91	72	4	modulation	modulation	NN
cord-015910-d9gxew91	72	5	of	of	IN
cord-015910-d9gxew91	72	6	inflammation	inflammation	NN
cord-015910-d9gxew91	72	7	by	by	IN
cord-015910-d9gxew91	72	8	these	these	DT
cord-015910-d9gxew91	72	9	dietary	dietary	JJ
cord-015910-d9gxew91	72	10	factors	factor	NNS
cord-015910-d9gxew91	72	11	are	be	VBP
cord-015910-d9gxew91	72	12	dealt	deal	VBN
cord-015910-d9gxew91	72	13	with	with	IN
cord-015910-d9gxew91	72	14	later	later	RB
cord-015910-d9gxew91	72	15	.	.	.
cord-015910-d9gxew91	73	1	An	an	DT
cord-015910-d9gxew91	73	2	unfortunate	unfortunate	JJ
cord-015910-d9gxew91	73	3	side	side	NN
cord-015910-d9gxew91	73	4	effect	effect	NN
cord-015910-d9gxew91	73	5	of	of	IN
cord-015910-d9gxew91	73	6	activation	activation	NN
cord-015910-d9gxew91	73	7	of	of	IN
cord-015910-d9gxew91	73	8	NF	nf	NN
cord-015910-d9gxew91	73	9	-	-	HYPH
cord-015910-d9gxew91	73	10	r	r	NN
cord-015910-d9gxew91	73	11	,	,	,
cord-015910-d9gxew91	73	12	B	b	NN
cord-015910-d9gxew91	73	13	arises	arise	VBZ
cord-015910-d9gxew91	73	14	from	from	IN
cord-015910-d9gxew91	73	15	the	the	DT
cord-015910-d9gxew91	73	16	ability	ability	NN
cord-015910-d9gxew91	73	17	of	of	IN
cord-015910-d9gxew91	73	18	the	the	DT
cord-015910-d9gxew91	73	19	transcription	transcription	NN
cord-015910-d9gxew91	73	20	factor	factor	NN
cord-015910-d9gxew91	73	21	to	to	TO
cord-015910-d9gxew91	73	22	activate	activate	VB
cord-015910-d9gxew91	73	23	transcription	transcription	NN
cord-015910-d9gxew91	73	24	of	of	IN
cord-015910-d9gxew91	73	25	the	the	DT
cord-015910-d9gxew91	73	26	genes	gene	NNS
cord-015910-d9gxew91	73	27	of	of	IN
cord-015910-d9gxew91	73	28	some	some	DT
cord-015910-d9gxew91	73	29	viruses	virus	NNS
cord-015910-d9gxew91	73	30	,	,	,
cord-015910-d9gxew91	73	31	such	such	JJ
cord-015910-d9gxew91	73	32	as	as	IN
cord-015910-d9gxew91	73	33	human	human	JJ
cord-015910-d9gxew91	73	34	immunodeficiency	immunodeficiency	NN
cord-015910-d9gxew91	73	35	virus	virus	NN
cord-015910-d9gxew91	73	36	(	(	-LRB-
cord-015910-d9gxew91	73	37	HIV	HIV	NNP
cord-015910-d9gxew91	73	38	)	)	-RRB-
cord-015910-d9gxew91	73	39	(	(	-LRB-
cord-015910-d9gxew91	73	40	Fig	Fig	NNP
cord-015910-d9gxew91	73	41	.	.	NNP
cord-015910-d9gxew91	73	42	4	4	CD
cord-015910-d9gxew91	73	43	)	)	-RRB-
cord-015910-d9gxew91	73	44	.	.	.
cord-015910-d9gxew91	74	1	This	this	DT
cord-015910-d9gxew91	74	2	sequence	sequence	NN
cord-015910-d9gxew91	74	3	of	of	IN
cord-015910-d9gxew91	74	4	events	event	NNS
cord-015910-d9gxew91	74	5	,	,	,
cord-015910-d9gxew91	74	6	in	in	IN
cord-015910-d9gxew91	74	7	the	the	DT
cord-015910-d9gxew91	74	8	case	case	NN
cord-015910-d9gxew91	74	9	of	of	IN
cord-015910-d9gxew91	74	10	HIV	HIV	NNP
cord-015910-d9gxew91	74	11	,	,	,
cord-015910-d9gxew91	74	12	accounts	account	VBZ
cord-015910-d9gxew91	74	13	for	for	IN
cord-015910-d9gxew91	74	14	the	the	DT
cord-015910-d9gxew91	74	15	ability	ability	NN
cord-015910-d9gxew91	74	16	of	of	IN
cord-015910-d9gxew91	74	17	minor	minor	JJ
cord-015910-d9gxew91	74	18	infections	infection	NNS
cord-015910-d9gxew91	74	19	to	to	TO
cord-015910-d9gxew91	74	20	speed	speed	VB
cord-015910-d9gxew91	74	21	the	the	DT
cord-015910-d9gxew91	74	22	progression	progression	NN
cord-015910-d9gxew91	74	23	of	of	IN
cord-015910-d9gxew91	74	24	individuals	individual	NNS
cord-015910-d9gxew91	74	25	who	who	WP
cord-015910-d9gxew91	74	26	are	be	VBP
cord-015910-d9gxew91	74	27	infected	infect	VBN
cord-015910-d9gxew91	74	28	with	with	IN
cord-015910-d9gxew91	74	29	HIV	HIV	NNP
cord-015910-d9gxew91	74	30	towards	towards	IN
cord-015910-d9gxew91	74	31	acquired	acquire	VBN
cord-015910-d9gxew91	74	32	immunodeficiency	immunodeficiency	NN
cord-015910-d9gxew91	74	33	syndrome	syndrome	NN
cord-015910-d9gxew91	74	34	(	(	-LRB-
cord-015910-d9gxew91	74	35	AIDS	AIDS	NNP
cord-015910-d9gxew91	74	36	)	)	-RRB-
cord-015910-d9gxew91	74	37	.	.	.
cord-015910-d9gxew91	75	1	Thus	thus	RB
cord-015910-d9gxew91	75	2	,	,	,
cord-015910-d9gxew91	75	3	if	if	IN
cord-015910-d9gxew91	75	4	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	75	5	defenses	defense	NNS
cord-015910-d9gxew91	75	6	are	be	VBP
cord-015910-d9gxew91	75	7	poor	poor	JJ
cord-015910-d9gxew91	75	8	,	,	,
cord-015910-d9gxew91	75	9	each	each	DT
cord-015910-d9gxew91	75	10	encounter	encounter	NN
cord-015910-d9gxew91	75	11	with	with	IN
cord-015910-d9gxew91	75	12	general	general	JJ
cord-015910-d9gxew91	75	13	infections	infection	NNS
cord-015910-d9gxew91	75	14	results	result	NNS
cord-015910-d9gxew91	75	15	in	in	IN
cord-015910-d9gxew91	75	16	cytokine	cytokine	NN
cord-015910-d9gxew91	75	17	and	and	CC
cord-015910-d9gxew91	75	18	oxidant	oxidant	JJ
cord-015910-d9gxew91	75	19	production	production	NN
cord-015910-d9gxew91	75	20	,	,	,
cord-015910-d9gxew91	75	21	NF-~zB	NF-~zB	NNP
cord-015910-d9gxew91	75	22	activation	activation	NN
cord-015910-d9gxew91	75	23	,	,	,
cord-015910-d9gxew91	75	24	and	and	CC
cord-015910-d9gxew91	75	25	an	an	DT
cord-015910-d9gxew91	75	26	increase	increase	NN
cord-015910-d9gxew91	75	27	in	in	IN
cord-015910-d9gxew91	75	28	HIV	HIV	NNP
cord-015910-d9gxew91	75	29	replication	replication	NN
cord-015910-d9gxew91	75	30	.	.	.
cord-015910-d9gxew91	76	1	It	-PRON-	PRP
cord-015910-d9gxew91	76	2	is	be	VBZ
cord-015910-d9gxew91	76	3	thus	thus	RB
cord-015910-d9gxew91	76	4	unfortunate	unfortunate	JJ
cord-015910-d9gxew91	76	5	that	that	IN
cord-015910-d9gxew91	76	6	reduced	reduce	VBN
cord-015910-d9gxew91	76	7	cellular	cellular	JJ
cord-015910-d9gxew91	76	8	concentrations	concentration	NNS
cord-015910-d9gxew91	76	9	of	of	IN
cord-015910-d9gxew91	76	10	GSH	GSH	NNP
cord-015910-d9gxew91	76	11	are	be	VBP
cord-015910-d9gxew91	76	12	a	a	DT
cord-015910-d9gxew91	76	13	common	common	JJ
cord-015910-d9gxew91	76	14	feature	feature	NN
cord-015910-d9gxew91	76	15	of	of	IN
cord-015910-d9gxew91	76	16	infections	infection	NNS
cord-015910-d9gxew91	76	17	,	,	,
cord-015910-d9gxew91	76	18	including	include	VBG
cord-015910-d9gxew91	76	19	that	that	IN
cord-015910-d9gxew91	76	20	from	from	IN
cord-015910-d9gxew91	76	21	the	the	DT
cord-015910-d9gxew91	76	22	HIV	HIV	NNP
cord-015910-d9gxew91	76	23	(	(	-LRB-
cord-015910-d9gxew91	76	24	Staal	Staal	NNP
cord-015910-d9gxew91	76	25	,	,	,
cord-015910-d9gxew91	76	26	Ela	Ela	NNP
cord-015910-d9gxew91	76	27	,	,	,
cord-015910-d9gxew91	76	28	&	&	CC
cord-015910-d9gxew91	76	29	Roederer	Roederer	NNP
cord-015910-d9gxew91	76	30	,	,	,
cord-015910-d9gxew91	76	31	1992	1992	CD
cord-015910-d9gxew91	76	32	)	)	-RRB-
cord-015910-d9gxew91	76	33	.	.	.
cord-015910-d9gxew91	77	1	Oxidant	oxidant	JJ
cord-015910-d9gxew91	77	2	damage	damage	NN
cord-015910-d9gxew91	77	3	to	to	IN
cord-015910-d9gxew91	77	4	cells	cell	NNS
cord-015910-d9gxew91	77	5	will	will	MD
cord-015910-d9gxew91	77	6	indirectly	indirectly	RB
cord-015910-d9gxew91	77	7	create	create	VB
cord-015910-d9gxew91	77	8	a	a	DT
cord-015910-d9gxew91	77	9	pro	pro	JJ
cord-015910-d9gxew91	77	10	-	-	JJ
cord-015910-d9gxew91	77	11	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	77	12	effect	effect	NN
cord-015910-d9gxew91	77	13	by	by	IN
cord-015910-d9gxew91	77	14	the	the	DT
cord-015910-d9gxew91	77	15	production	production	NN
cord-015910-d9gxew91	77	16	of	of	IN
cord-015910-d9gxew91	77	17	lipid	lipid	NN
cord-015910-d9gxew91	77	18	peroxides	peroxide	NNS
cord-015910-d9gxew91	77	19	.	.	.
cord-015910-d9gxew91	78	1	This	this	DT
cord-015910-d9gxew91	78	2	situation	situation	NN
cord-015910-d9gxew91	78	3	may	may	MD
cord-015910-d9gxew91	78	4	also	also	RB
cord-015910-d9gxew91	78	5	lead	lead	VB
cord-015910-d9gxew91	78	6	to	to	IN
cord-015910-d9gxew91	78	7	upregulation	upregulation	NN
cord-015910-d9gxew91	78	8	of	of	IN
cord-015910-d9gxew91	78	9	NF	nf	NN
cord-015910-d9gxew91	78	10	-	-	HYPH
cord-015910-d9gxew91	78	11	tcB	tcb	NN
cord-015910-d9gxew91	78	12	activity	activity	NN
cord-015910-d9gxew91	78	13	.	.	.
cord-015910-d9gxew91	79	1	As	as	IN
cord-015910-d9gxew91	79	2	will	will	MD
cord-015910-d9gxew91	79	3	be	be	VB
cord-015910-d9gxew91	79	4	seen	see	VBN
cord-015910-d9gxew91	79	5	in	in	IN
cord-015910-d9gxew91	79	6	later	later	JJ
cord-015910-d9gxew91	79	7	sections	section	NNS
cord-015910-d9gxew91	79	8	,	,	,
cord-015910-d9gxew91	79	9	genetic	genetic	JJ
cord-015910-d9gxew91	79	10	and	and	CC
cord-015910-d9gxew91	79	11	dietary	dietary	JJ
cord-015910-d9gxew91	79	12	factors	factor	NNS
cord-015910-d9gxew91	79	13	change	change	VBP
cord-015910-d9gxew91	79	14	the	the	DT
cord-015910-d9gxew91	79	15	intensity	intensity	NN
cord-015910-d9gxew91	79	16	of	of	IN
cord-015910-d9gxew91	79	17	the	the	DT
cord-015910-d9gxew91	79	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	79	19	response	response	NN
cord-015910-d9gxew91	79	20	.	.	.
cord-015910-d9gxew91	80	1	Thus	thus	RB
cord-015910-d9gxew91	80	2	,	,	,
cord-015910-d9gxew91	80	3	although	although	IN
cord-015910-d9gxew91	80	4	the	the	DT
cord-015910-d9gxew91	80	5	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	80	6	response	response	NN
cord-015910-d9gxew91	80	7	has	have	VBZ
cord-015910-d9gxew91	80	8	evolved	evolve	VBN
cord-015910-d9gxew91	80	9	to	to	TO
cord-015910-d9gxew91	80	10	ensure	ensure	VB
cord-015910-d9gxew91	80	11	the	the	DT
cord-015910-d9gxew91	80	12	survival	survival	NN
cord-015910-d9gxew91	80	13	of	of	IN
cord-015910-d9gxew91	80	14	the	the	DT
cord-015910-d9gxew91	80	15	human	human	JJ
cord-015910-d9gxew91	80	16	species	specie	NNS
cord-015910-d9gxew91	80	17	,	,	,
cord-015910-d9gxew91	80	18	individuals	individual	NNS
cord-015910-d9gxew91	80	19	may	may	MD
cord-015910-d9gxew91	80	20	die	die	VB
cord-015910-d9gxew91	80	21	as	as	IN
cord-015910-d9gxew91	80	22	a	a	DT
cord-015910-d9gxew91	80	23	result	result	NN
cord-015910-d9gxew91	80	24	primarily	primarily	RB
cord-015910-d9gxew91	80	25	of	of	IN
cord-015910-d9gxew91	80	26	the	the	DT
cord-015910-d9gxew91	80	27	response	response	NN
cord-015910-d9gxew91	80	28	to	to	IN
cord-015910-d9gxew91	80	29	invasion	invasion	NN
cord-015910-d9gxew91	80	30	rather	rather	RB
cord-015910-d9gxew91	80	31	than	than	IN
cord-015910-d9gxew91	80	32	from	from	IN
cord-015910-d9gxew91	80	33	the	the	DT
cord-015910-d9gxew91	80	34	invasive	invasive	JJ
cord-015910-d9gxew91	80	35	agent	agent	NN
cord-015910-d9gxew91	80	36	itself	-PRON-	PRP
cord-015910-d9gxew91	80	37	.	.	.
cord-015910-d9gxew91	81	1	It	-PRON-	PRP
cord-015910-d9gxew91	81	2	has	have	VBZ
cord-015910-d9gxew91	81	3	recently	recently	RB
cord-015910-d9gxew91	81	4	become	become	VBN
cord-015910-d9gxew91	81	5	apparent	apparent	JJ
cord-015910-d9gxew91	81	6	that	that	IN
cord-015910-d9gxew91	81	7	single	single	JJ
cord-015910-d9gxew91	81	8	base	base	NN
cord-015910-d9gxew91	81	9	changes	change	NNS
cord-015910-d9gxew91	81	10	(	(	-LRB-
cord-015910-d9gxew91	81	11	single	single	JJ
cord-015910-d9gxew91	81	12	-	-	HYPH
cord-015910-d9gxew91	81	13	nucleotide	nucleotide	NN
cord-015910-d9gxew91	81	14	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	81	15	[	[	-LRB-
cord-015910-d9gxew91	81	16	SNPs	SNPs	NNPS
cord-015910-d9gxew91	81	17	]	]	-RRB-
cord-015910-d9gxew91	81	18	)	)	-RRB-
cord-015910-d9gxew91	81	19	,	,	,
cord-015910-d9gxew91	81	20	usually	usually	RB
cord-015910-d9gxew91	81	21	in	in	IN
cord-015910-d9gxew91	81	22	the	the	DT
cord-015910-d9gxew91	81	23	promoter	promoter	NN
cord-015910-d9gxew91	81	24	region	region	NN
cord-015910-d9gxew91	81	25	of	of	IN
cord-015910-d9gxew91	81	26	genes	gene	NNS
cord-015910-d9gxew91	81	27	responsible	responsible	JJ
cord-015910-d9gxew91	81	28	for	for	IN
cord-015910-d9gxew91	81	29	producing	produce	VBG
cord-015910-d9gxew91	81	30	the	the	DT
cord-015910-d9gxew91	81	31	molecules	molecule	NNS
cord-015910-d9gxew91	81	32	involved	involve	VBN
cord-015910-d9gxew91	81	33	in	in	IN
cord-015910-d9gxew91	81	34	the	the	DT
cord-015910-d9gxew91	81	35	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	81	36	process	process	NN
cord-015910-d9gxew91	81	37	,	,	,
cord-015910-d9gxew91	81	38	exert	exert	VB
cord-015910-d9gxew91	81	39	a	a	DT
cord-015910-d9gxew91	81	40	modulatory	modulatory	JJ
cord-015910-d9gxew91	81	41	effect	effect	NN
cord-015910-d9gxew91	81	42	on	on	IN
cord-015910-d9gxew91	81	43	the	the	DT
cord-015910-d9gxew91	81	44	intensity	intensity	NN
cord-015910-d9gxew91	81	45	of	of	IN
cord-015910-d9gxew91	81	46	inflammation	inflammation	NN
cord-015910-d9gxew91	81	47	.	.	.
cord-015910-d9gxew91	82	1	In	in	IN
cord-015910-d9gxew91	82	2	vitro	vitro	FW
cord-015910-d9gxew91	82	3	production	production	NN
cord-015910-d9gxew91	82	4	of	of	IN
cord-015910-d9gxew91	82	5	TNF	TNF	NNP
cord-015910-d9gxew91	82	6	-	-	HYPH
cord-015910-d9gxew91	82	7	o~	o~	NNP
cord-015910-d9gxew91	82	8	by	by	IN
cord-015910-d9gxew91	82	9	peripheral	peripheral	JJ
cord-015910-d9gxew91	82	10	blood	blood	NN
cord-015910-d9gxew91	82	11	mononuclear	mononuclear	NN
cord-015910-d9gxew91	82	12	cells	cell	NNS
cord-015910-d9gxew91	82	13	(	(	-LRB-
cord-015910-d9gxew91	82	14	PBMCs	pbmc	NNS
cord-015910-d9gxew91	82	15	)	)	-RRB-
cord-015910-d9gxew91	82	16	from	from	IN
cord-015910-d9gxew91	82	17	healthy	healthy	JJ
cord-015910-d9gxew91	82	18	and	and	CC
cord-015910-d9gxew91	82	19	diseased	diseased	JJ
cord-015910-d9gxew91	82	20	subjects	subject	NNS
cord-015910-d9gxew91	82	21	stimulated	stimulate	VBN
cord-015910-d9gxew91	82	22	with	with	IN
cord-015910-d9gxew91	82	23	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	82	24	agents	agent	NNS
cord-015910-d9gxew91	82	25	shows	show	VBZ
cord-015910-d9gxew91	82	26	remarkable	remarkable	JJ
cord-015910-d9gxew91	82	27	individual	individual	JJ
cord-015910-d9gxew91	82	28	constancy	constancy	NN
cord-015910-d9gxew91	82	29	in	in	IN
cord-015910-d9gxew91	82	30	males	male	NNS
cord-015910-d9gxew91	82	31	and	and	CC
cord-015910-d9gxew91	82	32	postmenopausal	postmenopausal	JJ
cord-015910-d9gxew91	82	33	females	female	NNS
cord-015910-d9gxew91	83	1	(	(	-LRB-
cord-015910-d9gxew91	83	2	Jacob	Jacob	NNP
cord-015910-d9gxew91	83	3	et	et	NNP
cord-015910-d9gxew91	83	4	al	al	NNP
cord-015910-d9gxew91	83	5	.	.	NNP
cord-015910-d9gxew91	83	6	,	,	,
cord-015910-d9gxew91	83	7	1990	1990	CD
cord-015910-d9gxew91	83	8	)	)	-RRB-
cord-015910-d9gxew91	83	9	.	.	.
cord-015910-d9gxew91	84	1	This	this	DT
cord-015910-d9gxew91	84	2	constancy	constancy	NN
cord-015910-d9gxew91	84	3	suggests	suggest	VBZ
cord-015910-d9gxew91	84	4	that	that	IN
cord-015910-d9gxew91	84	5	genetic	genetic	JJ
cord-015910-d9gxew91	84	6	factors	factor	NNS
cord-015910-d9gxew91	84	7	exert	exert	VBP
cord-015910-d9gxew91	84	8	a	a	DT
cord-015910-d9gxew91	84	9	strong	strong	JJ
cord-015910-d9gxew91	84	10	influence	influence	NN
cord-015910-d9gxew91	84	11	.	.	.
cord-015910-d9gxew91	85	1	A	a	DT
cord-015910-d9gxew91	85	2	number	number	NN
cord-015910-d9gxew91	85	3	of	of	IN
cord-015910-d9gxew91	85	4	studies	study	NNS
cord-015910-d9gxew91	85	5	have	have	VBP
cord-015910-d9gxew91	85	6	shown	show	VBN
cord-015910-d9gxew91	85	7	that	that	IN
cord-015910-d9gxew91	85	8	SNPs	snp	NNS
cord-015910-d9gxew91	85	9	in	in	IN
cord-015910-d9gxew91	85	10	the	the	DT
cord-015910-d9gxew91	85	11	promoter	promoter	NN
cord-015910-d9gxew91	85	12	regions	region	NNS
cord-015910-d9gxew91	85	13	for	for	IN
cord-015910-d9gxew91	85	14	the	the	DT
cord-015910-d9gxew91	85	15	TNF	TNF	NNP
cord-015910-d9gxew91	85	16	-	-	HYPH
cord-015910-d9gxew91	85	17	o~	o~	NNP
cord-015910-d9gxew91	85	18	and	and	CC
cord-015910-d9gxew91	85	19	lymphotoxin	lymphotoxin	NNP
cord-015910-d9gxew91	85	20	Table	Table	NNP
cord-015910-d9gxew91	85	21	1	1	CD
cord-015910-d9gxew91	85	22	Single	Single	NNP
cord-015910-d9gxew91	85	23	Nucleotide	Nucleotide	NNP
cord-015910-d9gxew91	85	24	Polymorphisms	Polymorphisms	NNPS
cord-015910-d9gxew91	85	25	(	(	-LRB-
cord-015910-d9gxew91	85	26	SNPs	SNPs	NNPS
cord-015910-d9gxew91	85	27	)	)	-RRB-
cord-015910-d9gxew91	85	28	in	in	IN
cord-015910-d9gxew91	85	29	Cytokine	Cytokine	NNP
cord-015910-d9gxew91	85	30	Genes	Genes	NNP
cord-015910-d9gxew91	85	31	Associated	Associated	NNP
cord-015910-d9gxew91	85	32	With	with	IN
cord-015910-d9gxew91	85	33	Altered	altered	JJ
cord-015910-d9gxew91	85	34	Levels	level	NNS
cord-015910-d9gxew91	85	35	of	of	IN
cord-015910-d9gxew91	85	36	Cytokine	cytokine	NN
cord-015910-d9gxew91	85	37	Production	production	NN
cord-015910-d9gxew91	85	38	#	#	NN
cord-015910-d9gxew91	85	39	Gene	gene	NN
cord-015910-d9gxew91	85	40	and	and	CC
cord-015910-d9gxew91	85	41	location	location	NN
cord-015910-d9gxew91	85	42	of	of	IN
cord-015910-d9gxew91	85	43	polymorphism	polymorphism	NN
cord-015910-d9gxew91	85	44	in	in	IN
cord-015910-d9gxew91	85	45	promoter	promoter	NN
cord-015910-d9gxew91	85	46	region	region	NN
cord-015910-d9gxew91	85	47	Genotype	Genotype	NNP
cord-015910-d9gxew91	85	48	associated	associate	VBN
cord-015910-d9gxew91	85	49	with	with	IN
cord-015910-d9gxew91	85	50	raised	raise	VBN
cord-015910-d9gxew91	85	51	cytokine	cytokine	NN
cord-015910-d9gxew91	85	52	production	production	NN
cord-015910-d9gxew91	85	53	and	and	CC
cord-015910-d9gxew91	85	54	~	~	NFP
cord-015910-d9gxew91	85	55	or	or	CC
cord-015910-d9gxew91	85	56	altered	alter	VBN
cord-015910-d9gxew91	85	57	clinical	clinical	JJ
cord-015910-d9gxew91	85	58	outcome	outcome	NN
cord-015910-d9gxew91	85	59	to	to	IN
cord-015910-d9gxew91	85	60	inflammation	inflammation	NN
cord-015910-d9gxew91	85	61	b	b	.
cord-015910-d9gxew91	85	62	Pro	pro	JJ
cord-015910-d9gxew91	85	63	-	-	JJ
cord-015910-d9gxew91	85	64	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	85	65	cytokines	cytokine	NNS
cord-015910-d9gxew91	86	1	TNF	TNF	NNP
cord-015910-d9gxew91	86	2	-	-	HYPH
cord-015910-d9gxew91	86	3	t~	t~	NNP
cord-015910-d9gxew91	87	1	-308	-308	NNP
cord-015910-d9gxew91	87	2	LT	LT	NNP
cord-015910-d9gxew91	87	3	-	-	HYPH
cord-015910-d9gxew91	87	4	t~	t~	NNP
cord-015910-d9gxew91	88	1	+	+	SYM
cord-015910-d9gxew91	88	2	252	252	CD
cord-015910-d9gxew91	88	3	IL	IL	NNP
cord-015910-d9gxew91	88	4	-	-	HYPH
cord-015910-d9gxew91	88	5	l~-511	l~-511	NNP
cord-015910-d9gxew91	88	6	IL-6	IL-6	NNP
cord-015910-d9gxew91	88	7	-	-	HYPH
cord-015910-d9gxew91	88	8	174	174	CD
cord-015910-d9gxew91	88	9	Anti	anti	JJ
cord-015910-d9gxew91	88	10	-	-	JJ
cord-015910-d9gxew91	88	11	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	88	12	cytokines	cytokine	NNS
cord-015910-d9gxew91	88	13	IL-10	IL-10	NNP
cord-015910-d9gxew91	88	14	-	-	HYPH
cord-015910-d9gxew91	88	15	1082	1082	CD
cord-015910-d9gxew91	89	1	c	c	NNP
cord-015910-d9gxew91	89	2	TGF-1	TGF-1	NNP
cord-015910-d9gxew91	90	1	[	[	-LRB-
cord-015910-d9gxew91	90	2	~	~	NFP
cord-015910-d9gxew91	90	3	+	+	SYM
cord-015910-d9gxew91	90	4	915	915	CD
cord-015910-d9gxew91	90	5	(	(	-LRB-
cord-015910-d9gxew91	90	6	arg-25-pro	arg-25-pro	NNP
cord-015910-d9gxew91	90	7	)	)	-RRB-
cord-015910-d9gxew91	90	8	c	c	NNP
cord-015910-d9gxew91	90	9	TNF	TNF	NNP
cord-015910-d9gxew91	90	10	-	-	HYPH
cord-015910-d9gxew91	90	11	ct	ct	NNP
cord-015910-d9gxew91	90	12	-308	-308	NN
cord-015910-d9gxew91	90	13	A	a	DT
cord-015910-d9gxew91	90	14	allele	allele	NN
cord-015910-d9gxew91	90	15	(	(	-LRB-
cord-015910-d9gxew91	90	16	TNF2	TNF2	NNP
cord-015910-d9gxew91	90	17	)	)	-RRB-
cord-015910-d9gxew91	90	18	LT	LT	NNP
cord-015910-d9gxew91	90	19	-	-	HYPH
cord-015910-d9gxew91	90	20	t~	t~	NNP
cord-015910-d9gxew91	91	1	+	+	SYM
cord-015910-d9gxew91	91	2	252	252	CD
cord-015910-d9gxew91	91	3	AA	aa	NN
cord-015910-d9gxew91	92	1	(	(	-LRB-
cord-015910-d9gxew91	92	2	TNFB2:2	TNFB2:2	NNP
cord-015910-d9gxew91	92	3	)	)	-RRB-
cord-015910-d9gxew91	92	4	CT	CT	NNP
cord-015910-d9gxew91	92	5	or	or	CC
cord-015910-d9gxew91	92	6	TT	TT	NNP
cord-015910-d9gxew91	92	7	G	g	NN
cord-015910-d9gxew91	92	8	allelle	allelle	NN
cord-015910-d9gxew91	92	9	GG	GG	NNP
cord-015910-d9gxew91	92	10	GG	GG	NNP
cord-015910-d9gxew91	92	11	TNF	TNF	NNP
cord-015910-d9gxew91	92	12	,	,	,
cord-015910-d9gxew91	92	13	tumor	tumor	NN
cord-015910-d9gxew91	92	14	necrosis	necrosis	NN
cord-015910-d9gxew91	92	15	factor	factor	NN
cord-015910-d9gxew91	92	16	;	;	:
cord-015910-d9gxew91	92	17	LT	LT	NNP
cord-015910-d9gxew91	92	18	,	,	,
cord-015910-d9gxew91	92	19	lymphotoxin	lymphotoxin	NNP
cord-015910-d9gxew91	92	20	;	;	:
cord-015910-d9gxew91	92	21	IL	IL	NNP
cord-015910-d9gxew91	92	22	,	,	,
cord-015910-d9gxew91	92	23	interleukin	interleukin	NN
cord-015910-d9gxew91	92	24	;	;	:
cord-015910-d9gxew91	92	25	TGF	TGF	NNP
cord-015910-d9gxew91	92	26	,	,	,
cord-015910-d9gxew91	92	27	transforming	transform	VBG
cord-015910-d9gxew91	92	28	growth	growth	NN
cord-015910-d9gxew91	92	29	factor	factor	NN
cord-015910-d9gxew91	92	30	;	;	:
cord-015910-d9gxew91	92	31	C	c	NN
cord-015910-d9gxew91	92	32	,	,	,
cord-015910-d9gxew91	92	33	cytosine	cytosine	NN
cord-015910-d9gxew91	92	34	;	;	:
cord-015910-d9gxew91	92	35	G	g	NN
cord-015910-d9gxew91	92	36	,	,	,
cord-015910-d9gxew91	92	37	guanosine	guanosine	NN
cord-015910-d9gxew91	92	38	;	;	:
cord-015910-d9gxew91	92	39	T	T	NNP
cord-015910-d9gxew91	92	40	,	,	,
cord-015910-d9gxew91	92	41	thymidine	thymidine	NN
cord-015910-d9gxew91	92	42	,	,	,
cord-015910-d9gxew91	92	43	A	a	NN
cord-015910-d9gxew91	92	44	,	,	,
cord-015910-d9gxew91	92	45	adenine	adenine	NN
cord-015910-d9gxew91	92	46	.	.	.
cord-015910-d9gxew91	93	1	aThe	athe	JJ
cord-015910-d9gxew91	93	2	location	location	NN
cord-015910-d9gxew91	93	3	of	of	IN
cord-015910-d9gxew91	93	4	the	the	DT
cord-015910-d9gxew91	93	5	polymorphism	polymorphism	NN
cord-015910-d9gxew91	93	6	is	be	VBZ
cord-015910-d9gxew91	93	7	indicated	indicate	VBN
cord-015910-d9gxew91	93	8	by	by	IN
cord-015910-d9gxew91	93	9	the	the	DT
cord-015910-d9gxew91	93	10	nucleotide	nucleotide	JJ
cord-015910-d9gxew91	93	11	position	position	NN
cord-015910-d9gxew91	93	12	in	in	IN
cord-015910-d9gxew91	93	13	the	the	DT
cord-015910-d9gxew91	93	14	promotor	promotor	NN
cord-015910-d9gxew91	93	15	region	region	NN
cord-015910-d9gxew91	93	16	.	.	.
cord-015910-d9gxew91	94	1	bpoor	bpoor	NNP
cord-015910-d9gxew91	94	2	clinical	clinical	JJ
cord-015910-d9gxew91	94	3	outcome	outcome	NN
cord-015910-d9gxew91	94	4	for	for	IN
cord-015910-d9gxew91	94	5	pro	pro	JJ
cord-015910-d9gxew91	94	6	-	-	JJ
cord-015910-d9gxew91	94	7	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	94	8	cytokines	cytokine	NNS
cord-015910-d9gxew91	94	9	.	.	.
cord-015910-d9gxew91	95	1	Clmproved	clmproved	JJ
cord-015910-d9gxew91	95	2	clinical	clinical	JJ
cord-015910-d9gxew91	95	3	outcome	outcome	NN
cord-015910-d9gxew91	95	4	for	for	IN
cord-015910-d9gxew91	95	5	anti	anti	JJ
cord-015910-d9gxew91	95	6	-	-	JJ
cord-015910-d9gxew91	95	7	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	95	8	cytokines	cytokine	NNS
cord-015910-d9gxew91	95	9	.	.	.
cord-015910-d9gxew91	96	1	(	(	-LRB-
cord-015910-d9gxew91	96	2	LT)-o~	lt)-o~	NN
cord-015910-d9gxew91	96	3	genes	gene	NNS
cord-015910-d9gxew91	96	4	are	be	VBP
cord-015910-d9gxew91	96	5	associated	associate	VBN
cord-015910-d9gxew91	96	6	with	with	IN
cord-015910-d9gxew91	96	7	differential	differential	JJ
cord-015910-d9gxew91	96	8	TNF	TNF	NNP
cord-015910-d9gxew91	96	9	-	-	HYPH
cord-015910-d9gxew91	96	10	t~	t~	NNP
cord-015910-d9gxew91	96	11	production	production	NN
cord-015910-d9gxew91	96	12	(	(	-LRB-
cord-015910-d9gxew91	96	13	Allen	Allen	NNP
cord-015910-d9gxew91	96	14	,	,	,
cord-015910-d9gxew91	96	15	1999	1999	CD
cord-015910-d9gxew91	96	16	;	;	:
cord-015910-d9gxew91	96	17	Messer	Messer	NNP
cord-015910-d9gxew91	96	18	et	et	NNP
cord-015910-d9gxew91	96	19	al	al	NNP
cord-015910-d9gxew91	96	20	.	.	NNP
cord-015910-d9gxew91	96	21	,	,	,
cord-015910-d9gxew91	96	22	1991	1991	CD
cord-015910-d9gxew91	96	23	;	;	:
cord-015910-d9gxew91	96	24	Wilson	Wilson	NNP
cord-015910-d9gxew91	96	25	et	et	NNP
cord-015910-d9gxew91	96	26	al	al	NNP
cord-015910-d9gxew91	96	27	.	.	NNP
cord-015910-d9gxew91	96	28	,	,	,
cord-015910-d9gxew91	96	29	1993	1993	CD
cord-015910-d9gxew91	96	30	)	)	-RRB-
cord-015910-d9gxew91	96	31	.	.	.
cord-015910-d9gxew91	97	1	The	the	DT
cord-015910-d9gxew91	97	2	TNF2	TNF2	NNP
cord-015910-d9gxew91	97	3	(	(	-LRB-
cord-015910-d9gxew91	97	4	A	a	NN
cord-015910-d9gxew91	97	5	)	)	-RRB-
cord-015910-d9gxew91	98	1	and	and	CC
cord-015910-d9gxew91	98	2	TNFB2	TNFB2	NNP
cord-015910-d9gxew91	98	3	(	(	-LRB-
cord-015910-d9gxew91	98	4	A	a	NN
cord-015910-d9gxew91	98	5	)	)	-RRB-
cord-015910-d9gxew91	98	6	alleles	allele	NNS
cord-015910-d9gxew91	98	7	(	(	-LRB-
cord-015910-d9gxew91	98	8	at	at	IN
cord-015910-d9gxew91	98	9	-308	-308	NN
cord-015910-d9gxew91	98	10	and	and	CC
cord-015910-d9gxew91	98	11	+252	+252	NNP
cord-015910-d9gxew91	98	12	for	for	IN
cord-015910-d9gxew91	98	13	the	the	DT
cord-015910-d9gxew91	98	14	TNF	TNF	NNP
cord-015910-d9gxew91	98	15	-	-	HYPH
cord-015910-d9gxew91	98	16	o~	o~	NNP
cord-015910-d9gxew91	98	17	and	and	CC
cord-015910-d9gxew91	98	18	LT	LT	NNP
cord-015910-d9gxew91	98	19	-	-	HYPH
cord-015910-d9gxew91	98	20	t~	t~	NNP
cord-015910-d9gxew91	98	21	genes	gene	NNS
cord-015910-d9gxew91	98	22	,	,	,
cord-015910-d9gxew91	98	23	respectively	respectively	RB
cord-015910-d9gxew91	98	24	)	)	-RRB-
cord-015910-d9gxew91	98	25	are	be	VBP
cord-015910-d9gxew91	98	26	linked	link	VBN
cord-015910-d9gxew91	98	27	to	to	IN
cord-015910-d9gxew91	98	28	high	high	JJ
cord-015910-d9gxew91	98	29	TNF	TNF	NNP
cord-015910-d9gxew91	98	30	production	production	NN
cord-015910-d9gxew91	98	31	,	,	,
cord-015910-d9gxew91	98	32	particularly	particularly	RB
cord-015910-d9gxew91	98	33	in	in	IN
cord-015910-d9gxew91	98	34	homozygous	homozygous	JJ
cord-015910-d9gxew91	98	35	individuals	individual	NNS
cord-015910-d9gxew91	98	36	.	.	.
cord-015910-d9gxew91	99	1	The	the	DT
cord-015910-d9gxew91	99	2	SNP	SNP	NNP
cord-015910-d9gxew91	99	3	in	in	IN
cord-015910-d9gxew91	99	4	the	the	DT
cord-015910-d9gxew91	99	5	LT	LT	NNP
cord-015910-d9gxew91	99	6	-	-	HYPH
cord-015910-d9gxew91	99	7	ot	ot	NN
cord-015910-d9gxew91	99	8	gene	gene	NN
cord-015910-d9gxew91	99	9	(	(	-LRB-
cord-015910-d9gxew91	99	10	+252	+252	NNP
cord-015910-d9gxew91	99	11	)	)	-RRB-
cord-015910-d9gxew91	99	12	is	be	VBZ
cord-015910-d9gxew91	99	13	found	find	VBN
cord-015910-d9gxew91	99	14	in	in	IN
cord-015910-d9gxew91	99	15	linkage	linkage	NN
cord-015910-d9gxew91	99	16	disequilibrium	disequilibrium	NN
cord-015910-d9gxew91	99	17	with	with	IN
cord-015910-d9gxew91	99	18	major	major	JJ
cord-015910-d9gxew91	99	19	histocompatibility	histocompatibility	NN
cord-015910-d9gxew91	99	20	molecules	molecule	NNS
cord-015910-d9gxew91	99	21	HLA	HLA	NNP
cord-015910-d9gxew91	99	22	-	-	HYPH
cord-015910-d9gxew91	99	23	A1	A1	NNP
cord-015910-d9gxew91	99	24	,	,	,
cord-015910-d9gxew91	99	25	B8	B8	NNP
cord-015910-d9gxew91	99	26	,	,	,
cord-015910-d9gxew91	99	27	DR3	DR3	NNP
cord-015910-d9gxew91	99	28	(	(	-LRB-
cord-015910-d9gxew91	99	29	Messer	Messer	NNP
cord-015910-d9gxew91	99	30	et	et	NNP
cord-015910-d9gxew91	99	31	al	al	NNP
cord-015910-d9gxew91	99	32	.	.	NNP
cord-015910-d9gxew91	99	33	,	,	,
cord-015910-d9gxew91	99	34	1991	1991	CD
cord-015910-d9gxew91	99	35	;	;	:
cord-015910-d9gxew91	99	36	Wilson	Wilson	NNP
cord-015910-d9gxew91	99	37	et	et	NNP
cord-015910-d9gxew91	99	38	al	al	NNP
cord-015910-d9gxew91	99	39	.	.	NNP
cord-015910-d9gxew91	99	40	,	,	,
cord-015910-d9gxew91	99	41	1993	1993	CD
cord-015910-d9gxew91	99	42	)	)	-RRB-
cord-015910-d9gxew91	99	43	.	.	.
cord-015910-d9gxew91	100	1	This	this	DT
cord-015910-d9gxew91	100	2	genotype	genotype	NN
cord-015910-d9gxew91	100	3	has	have	VBZ
cord-015910-d9gxew91	100	4	also	also	RB
cord-015910-d9gxew91	100	5	been	be	VBN
cord-015910-d9gxew91	100	6	reported	report	VBN
cord-015910-d9gxew91	100	7	to	to	TO
cord-015910-d9gxew91	100	8	define	define	VB
cord-015910-d9gxew91	100	9	a	a	DT
cord-015910-d9gxew91	100	10	TNF	TNF	NNP
cord-015910-d9gxew91	100	11	"	"	``
cord-015910-d9gxew91	100	12	high	high	JJ
cord-015910-d9gxew91	100	13	expresser	expresser	NN
cord-015910-d9gxew91	100	14	"	"	''
cord-015910-d9gxew91	100	15	haplotype	haplotype	NN
cord-015910-d9gxew91	100	16	(	(	-LRB-
cord-015910-d9gxew91	100	17	Warzocha	Warzocha	NNP
cord-015910-d9gxew91	100	18	et	et	NNP
cord-015910-d9gxew91	100	19	al	al	NNP
cord-015910-d9gxew91	100	20	.	.	NNP
cord-015910-d9gxew91	100	21	,	,	,
cord-015910-d9gxew91	100	22	1998	1998	CD
cord-015910-d9gxew91	100	23	)	)	-RRB-
cord-015910-d9gxew91	100	24	,	,	,
cord-015910-d9gxew91	100	25	in	in	IN
cord-015910-d9gxew91	100	26	addition	addition	NN
cord-015910-d9gxew91	100	27	to	to	IN
cord-015910-d9gxew91	100	28	modifying	modify	VBG
cord-015910-d9gxew91	100	29	expression	expression	NN
cord-015910-d9gxew91	100	30	of	of	IN
cord-015910-d9gxew91	100	31	LT	LT	NNP
cord-015910-d9gxew91	100	32	-	-	HYPH
cord-015910-d9gxew91	100	33	o~	o~	NNP
cord-015910-d9gxew91	100	34	itself	-PRON-	PRP
cord-015910-d9gxew91	101	1	(	(	-LRB-
cord-015910-d9gxew91	101	2	Messer	Messer	NNP
cord-015910-d9gxew91	101	3	et	et	NNP
cord-015910-d9gxew91	101	4	al	al	NNP
cord-015910-d9gxew91	101	5	.	.	NNP
cord-015910-d9gxew91	101	6	,	,	,
cord-015910-d9gxew91	101	7	1991	1991	CD
cord-015910-d9gxew91	101	8	)	)	-RRB-
cord-015910-d9gxew91	101	9	.	.	.
cord-015910-d9gxew91	102	1	A	a	DT
cord-015910-d9gxew91	102	2	large	large	JJ
cord-015910-d9gxew91	102	3	body	body	NN
cord-015910-d9gxew91	102	4	of	of	IN
cord-015910-d9gxew91	102	5	research	research	NN
cord-015910-d9gxew91	102	6	has	have	VBZ
cord-015910-d9gxew91	102	7	indicated	indicate	VBN
cord-015910-d9gxew91	102	8	that	that	IN
cord-015910-d9gxew91	102	9	SNPs	snp	NNS
cord-015910-d9gxew91	102	10	occur	occur	VBP
cord-015910-d9gxew91	102	11	in	in	IN
cord-015910-d9gxew91	102	12	the	the	DT
cord-015910-d9gxew91	102	13	upstream	upstream	JJ
cord-015910-d9gxew91	102	14	regulatory	regulatory	JJ
cord-015910-d9gxew91	102	15	(	(	-LRB-
cord-015910-d9gxew91	102	16	promoter	promoter	NN
cord-015910-d9gxew91	102	17	)	)	-RRB-
cord-015910-d9gxew91	102	18	regions	region	NNS
cord-015910-d9gxew91	102	19	of	of	IN
cord-015910-d9gxew91	102	20	many	many	JJ
cord-015910-d9gxew91	102	21	cytokine	cytokine	NN
cord-015910-d9gxew91	102	22	genes	gene	NNS
cord-015910-d9gxew91	102	23	(	(	-LRB-
cord-015910-d9gxew91	102	24	Bidwell	Bidwell	NNP
cord-015910-d9gxew91	102	25	et	et	NNP
cord-015910-d9gxew91	102	26	al	al	NNP
cord-015910-d9gxew91	102	27	.	.	NNP
cord-015910-d9gxew91	102	28	,	,	,
cord-015910-d9gxew91	102	29	2001	2001	CD
cord-015910-d9gxew91	102	30	)	)	-RRB-
cord-015910-d9gxew91	102	31	.	.	.
cord-015910-d9gxew91	103	1	Many	many	JJ
cord-015910-d9gxew91	103	2	of	of	IN
cord-015910-d9gxew91	103	3	these	these	DT
cord-015910-d9gxew91	103	4	genetic	genetic	JJ
cord-015910-d9gxew91	103	5	variations	variation	NNS
cord-015910-d9gxew91	103	6	influence	influence	VBP
cord-015910-d9gxew91	103	7	the	the	DT
cord-015910-d9gxew91	103	8	level	level	NN
cord-015910-d9gxew91	103	9	of	of	IN
cord-015910-d9gxew91	103	10	expression	expression	NN
cord-015910-d9gxew91	103	11	of	of	IN
cord-015910-d9gxew91	103	12	genes	gene	NNS
cord-015910-d9gxew91	103	13	and	and	CC
cord-015910-d9gxew91	103	14	the	the	DT
cord-015910-d9gxew91	103	15	outcome	outcome	NN
cord-015910-d9gxew91	103	16	from	from	IN
cord-015910-d9gxew91	103	17	the	the	DT
cord-015910-d9gxew91	103	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	103	19	response	response	NN
cord-015910-d9gxew91	103	20	.	.	.
cord-015910-d9gxew91	104	1	Both	both	DT
cord-015910-d9gxew91	104	2	pro	pro	JJ
cord-015910-d9gxew91	104	3	-	-	JJ
cord-015910-d9gxew91	104	4	and	and	CC
cord-015910-d9gxew91	104	5	anti	anti	JJ
cord-015910-d9gxew91	104	6	-	-	JJ
cord-015910-d9gxew91	104	7	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	104	8	cytokines	cytokine	NNS
cord-015910-d9gxew91	104	9	are	be	VBP
cord-015910-d9gxew91	104	10	influenced	influence	VBN
cord-015910-d9gxew91	104	11	by	by	IN
cord-015910-d9gxew91	104	12	the	the	DT
cord-015910-d9gxew91	104	13	differences	difference	NNS
cord-015910-d9gxew91	104	14	in	in	IN
cord-015910-d9gxew91	104	15	genotype	genotype	NN
cord-015910-d9gxew91	104	16	(	(	-LRB-
cord-015910-d9gxew91	104	17	Allen	Allen	NNP
cord-015910-d9gxew91	104	18	1999	1999	CD
cord-015910-d9gxew91	104	19	;	;	:
cord-015910-d9gxew91	104	20	Turner	Turner	NNP
cord-015910-d9gxew91	104	21	,	,	,
cord-015910-d9gxew91	104	22	Williams	Williams	NNP
cord-015910-d9gxew91	104	23	,	,	,
cord-015910-d9gxew91	104	24	&	&	CC
cord-015910-d9gxew91	104	25	Sankeran	Sankeran	NNP
cord-015910-d9gxew91	104	26	,	,	,
cord-015910-d9gxew91	104	27	1997	1997	CD
cord-015910-d9gxew91	104	28	)	)	-RRB-
cord-015910-d9gxew91	104	29	.	.	.
cord-015910-d9gxew91	105	1	A	a	DT
cord-015910-d9gxew91	105	2	number	number	NN
cord-015910-d9gxew91	105	3	of	of	IN
cord-015910-d9gxew91	105	4	SNPs	snp	NNS
cord-015910-d9gxew91	105	5	that	that	WDT
cord-015910-d9gxew91	105	6	have	have	VBP
cord-015910-d9gxew91	105	7	been	be	VBN
cord-015910-d9gxew91	105	8	implicated	implicate	VBN
cord-015910-d9gxew91	105	9	in	in	IN
cord-015910-d9gxew91	105	10	the	the	DT
cord-015910-d9gxew91	105	11	outcome	outcome	NN
cord-015910-d9gxew91	105	12	of	of	IN
cord-015910-d9gxew91	105	13	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	105	14	stress	stress	NN
cord-015910-d9gxew91	105	15	are	be	VBP
cord-015910-d9gxew91	105	16	shown	show	VBN
cord-015910-d9gxew91	105	17	in	in	IN
cord-015910-d9gxew91	105	18	Table	Table	NNP
cord-015910-d9gxew91	105	19	1	1	CD
cord-015910-d9gxew91	105	20	.	.	.
cord-015910-d9gxew91	106	1	NF	nf	NN
cord-015910-d9gxew91	106	2	-	-	HYPH
cord-015910-d9gxew91	106	3	lcB	lcb	NN
cord-015910-d9gxew91	106	4	is	be	VBZ
cord-015910-d9gxew91	106	5	activated	activate	VBN
cord-015910-d9gxew91	106	6	by	by	IN
cord-015910-d9gxew91	106	7	oxidants	oxidant	NNS
cord-015910-d9gxew91	106	8	and	and	CC
cord-015910-d9gxew91	106	9	switches	switch	NNS
cord-015910-d9gxew91	106	10	on	on	IN
cord-015910-d9gxew91	106	11	many	many	JJ
cord-015910-d9gxew91	106	12	of	of	IN
cord-015910-d9gxew91	106	13	the	the	DT
cord-015910-d9gxew91	106	14	genes	gene	NNS
cord-015910-d9gxew91	106	15	involved	involve	VBN
cord-015910-d9gxew91	106	16	in	in	IN
cord-015910-d9gxew91	106	17	the	the	DT
cord-015910-d9gxew91	106	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	106	19	response	response	NN
cord-015910-d9gxew91	106	20	(	(	-LRB-
cord-015910-d9gxew91	106	21	cytokines	cytokine	NNS
cord-015910-d9gxew91	106	22	,	,	,
cord-015910-d9gxew91	106	23	adhesion	adhesion	NN
cord-015910-d9gxew91	106	24	molecules	molecule	NNS
cord-015910-d9gxew91	106	25	,	,	,
cord-015910-d9gxew91	106	26	and	and	CC
cord-015910-d9gxew91	106	27	acute	acute	JJ
cord-015910-d9gxew91	106	28	-	-	HYPH
cord-015910-d9gxew91	106	29	phase	phase	NN
cord-015910-d9gxew91	106	30	proteins	protein	NNS
cord-015910-d9gxew91	106	31	)	)	-RRB-
cord-015910-d9gxew91	106	32	.	.	.
cord-015910-d9gxew91	107	1	Enhancement	enhancement	NN
cord-015910-d9gxew91	107	2	of	of	IN
cord-015910-d9gxew91	107	3	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	107	4	defenses	defense	NNS
cord-015910-d9gxew91	107	5	is	be	VBZ
cord-015910-d9gxew91	107	6	important	important	JJ
cord-015910-d9gxew91	107	7	in	in	IN
cord-015910-d9gxew91	107	8	protecting	protect	VBG
cord-015910-d9gxew91	107	9	healthy	healthy	JJ
cord-015910-d9gxew91	107	10	tissues	tissue	NNS
cord-015910-d9gxew91	107	11	and	and	CC
cord-015910-d9gxew91	107	12	in	in	IN
cord-015910-d9gxew91	107	13	preventing	prevent	VBG
cord-015910-d9gxew91	107	14	excessive	excessive	JJ
cord-015910-d9gxew91	107	15	activation	activation	NN
cord-015910-d9gxew91	107	16	of	of	IN
cord-015910-d9gxew91	107	17	NF-~zB	nf-~zb	NN
cord-015910-d9gxew91	107	18	by	by	IN
cord-015910-d9gxew91	107	19	the	the	DT
cord-015910-d9gxew91	107	20	oxidative	oxidative	JJ
cord-015910-d9gxew91	107	21	cellular	cellular	JJ
cord-015910-d9gxew91	107	22	environment	environment	NN
cord-015910-d9gxew91	107	23	during	during	IN
cord-015910-d9gxew91	107	24	inflammation	inflammation	NN
cord-015910-d9gxew91	107	25	(	(	-LRB-
cord-015910-d9gxew91	107	26	Schreck	Schreck	NNP
cord-015910-d9gxew91	107	27	et	et	NNP
cord-015910-d9gxew91	107	28	al	al	NNP
cord-015910-d9gxew91	107	29	.	.	NNP
cord-015910-d9gxew91	107	30	,	,	,
cord-015910-d9gxew91	107	31	1991	1991	CD
cord-015910-d9gxew91	107	32	)	)	-RRB-
cord-015910-d9gxew91	107	33	.	.	.
cord-015910-d9gxew91	108	1	NF	NF	NNP
cord-015910-d9gxew91	108	2	-	-	HYPH
cord-015910-d9gxew91	108	3	rd3	rd3	NNP
cord-015910-d9gxew91	108	4	upregulates	upregulate	VBZ
cord-015910-d9gxew91	108	5	cytokine	cytokine	NN
cord-015910-d9gxew91	108	6	and	and	CC
cord-015910-d9gxew91	108	7	adhesion	adhesion	NN
cord-015910-d9gxew91	108	8	molecule	molecule	NN
cord-015910-d9gxew91	108	9	expression	expression	NN
cord-015910-d9gxew91	108	10	,	,	,
cord-015910-d9gxew91	108	11	increasing	increase	VBG
cord-015910-d9gxew91	108	12	the	the	DT
cord-015910-d9gxew91	108	13	risk	risk	NN
cord-015910-d9gxew91	108	14	of	of	IN
cord-015910-d9gxew91	108	15	host	host	NN
cord-015910-d9gxew91	108	16	damage	damage	NN
cord-015910-d9gxew91	108	17	(	(	-LRB-
cord-015910-d9gxew91	108	18	Jersmann	Jersmann	NNP
cord-015910-d9gxew91	108	19	,	,	,
cord-015910-d9gxew91	108	20	Hii	Hii	NNP
cord-015910-d9gxew91	108	21	,	,	,
cord-015910-d9gxew91	108	22	Ferrante	Ferrante	NNP
cord-015910-d9gxew91	108	23	,	,	,
cord-015910-d9gxew91	108	24	&	&	CC
cord-015910-d9gxew91	108	25	Ferrante	Ferrante	NNP
cord-015910-d9gxew91	108	26	,	,	,
cord-015910-d9gxew91	108	27	2001	2001	CD
cord-015910-d9gxew91	108	28	)	)	-RRB-
cord-015910-d9gxew91	108	29	.	.	.
cord-015910-d9gxew91	109	1	Genetic	genetic	JJ
cord-015910-d9gxew91	109	2	factors	factor	NNS
cord-015910-d9gxew91	109	3	also	also	RB
cord-015910-d9gxew91	109	4	influence	influence	VBP
cord-015910-d9gxew91	109	5	the	the	DT
cord-015910-d9gxew91	109	6	propensity	propensity	NN
cord-015910-d9gxew91	109	7	of	of	IN
cord-015910-d9gxew91	109	8	individuals	individual	NNS
cord-015910-d9gxew91	109	9	to	to	TO
cord-015910-d9gxew91	109	10	produce	produce	VB
cord-015910-d9gxew91	109	11	oxidant	oxidant	JJ
cord-015910-d9gxew91	109	12	molecules	molecule	NNS
cord-015910-d9gxew91	109	13	and	and	CC
cord-015910-d9gxew91	109	14	thereby	thereby	RB
cord-015910-d9gxew91	109	15	influence	influence	VB
cord-015910-d9gxew91	109	16	NF	NF	NNP
cord-015910-d9gxew91	109	17	-	-	HYPH
cord-015910-d9gxew91	109	18	rd3	rd3	NNP
cord-015910-d9gxew91	109	19	activation	activation	NN
cord-015910-d9gxew91	109	20	.	.	.
cord-015910-d9gxew91	110	1	Natural	natural	JJ
cord-015910-d9gxew91	110	2	resistance	resistance	NN
cord-015910-d9gxew91	110	3	-	-	HYPH
cord-015910-d9gxew91	110	4	associated	associate	VBN
cord-015910-d9gxew91	110	5	macrophage	macrophage	NN
cord-015910-d9gxew91	110	6	protein	protein	NN
cord-015910-d9gxew91	110	7	1	1	CD
cord-015910-d9gxew91	110	8	(	(	-LRB-
cord-015910-d9gxew91	110	9	NRAMP1	NRAMP1	NNP
cord-015910-d9gxew91	110	10	)	)	-RRB-
cord-015910-d9gxew91	110	11	has	have	VBZ
cord-015910-d9gxew91	110	12	effects	effect	NNS
cord-015910-d9gxew91	110	13	on	on	IN
cord-015910-d9gxew91	110	14	macrophage	macrophage	NN
cord-015910-d9gxew91	110	15	functions	function	NNS
cord-015910-d9gxew91	110	16	,	,	,
cord-015910-d9gxew91	110	17	including	include	VBG
cord-015910-d9gxew91	110	18	TNF	TNF	NNP
cord-015910-d9gxew91	110	19	-	-	HYPH
cord-015910-d9gxew91	110	20	ct	ct	NNP
cord-015910-d9gxew91	110	21	production	production	NN
cord-015910-d9gxew91	110	22	and	and	CC
cord-015910-d9gxew91	110	23	activation	activation	NN
cord-015910-d9gxew91	110	24	of	of	IN
cord-015910-d9gxew91	110	25	inducible	inducible	JJ
cord-015910-d9gxew91	110	26	nitric	nitric	NN
cord-015910-d9gxew91	110	27	oxide	oxide	NN
cord-015910-d9gxew91	110	28	synthase	synthase	NN
cord-015910-d9gxew91	110	29	(	(	-LRB-
cord-015910-d9gxew91	110	30	iNOS	iNOS	NNP
cord-015910-d9gxew91	110	31	)	)	-RRB-
cord-015910-d9gxew91	110	32	,	,	,
cord-015910-d9gxew91	110	33	which	which	WDT
cord-015910-d9gxew91	110	34	occurs	occur	VBZ
cord-015910-d9gxew91	110	35	by	by	IN
cord-015910-d9gxew91	110	36	cooperation	cooperation	NN
cord-015910-d9gxew91	110	37	between	between	IN
cord-015910-d9gxew91	110	38	the	the	DT
cord-015910-d9gxew91	110	39	NRAMP1	NRAMP1	NNP
cord-015910-d9gxew91	110	40	,	,	,
cord-015910-d9gxew91	110	41	TNF	TNF	NNP
cord-015910-d9gxew91	110	42	-	-	HYPH
cord-015910-d9gxew91	110	43	o~	o~	NNP
cord-015910-d9gxew91	110	44	,	,	,
cord-015910-d9gxew91	110	45	and	and	CC
cord-015910-d9gxew91	110	46	LT	LT	NNP
cord-015910-d9gxew91	110	47	-	-	HYPH
cord-015910-d9gxew91	110	48	o~	o~	NNP
cord-015910-d9gxew91	110	49	genes	gene	NNS
cord-015910-d9gxew91	110	50	(	(	-LRB-
cord-015910-d9gxew91	110	51	Ables	Ables	NNP
cord-015910-d9gxew91	110	52	et	et	NNP
cord-015910-d9gxew91	110	53	al	al	NNP
cord-015910-d9gxew91	110	54	.	.	NNP
cord-015910-d9gxew91	110	55	,	,	,
cord-015910-d9gxew91	110	56	2001	2001	CD
cord-015910-d9gxew91	110	57	)	)	-RRB-
cord-015910-d9gxew91	110	58	.	.	.
cord-015910-d9gxew91	111	1	There	there	EX
cord-015910-d9gxew91	111	2	are	be	VBP
cord-015910-d9gxew91	111	3	four	four	CD
cord-015910-d9gxew91	111	4	variations	variation	NNS
cord-015910-d9gxew91	111	5	in	in	IN
cord-015910-d9gxew91	111	6	the	the	DT
cord-015910-d9gxew91	111	7	NRAMP1	NRAMP1	NNP
cord-015910-d9gxew91	111	8	gene	gene	NN
cord-015910-d9gxew91	111	9	,	,	,
cord-015910-d9gxew91	111	10	resulting	result	VBG
cord-015910-d9gxew91	111	11	in	in	IN
cord-015910-d9gxew91	111	12	different	different	JJ
cord-015910-d9gxew91	111	13	basal	basal	NN
cord-015910-d9gxew91	111	14	levels	level	NNS
cord-015910-d9gxew91	111	15	of	of	IN
cord-015910-d9gxew91	111	16	activity	activity	NN
cord-015910-d9gxew91	111	17	and	and	CC
cord-015910-d9gxew91	111	18	differential	differential	JJ
cord-015910-d9gxew91	111	19	sensitivity	sensitivity	NN
cord-015910-d9gxew91	111	20	to	to	IN
cord-015910-d9gxew91	111	21	stimulation	stimulation	NN
cord-015910-d9gxew91	111	22	by	by	IN
cord-015910-d9gxew91	111	23	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	111	24	agents	agent	NNS
cord-015910-d9gxew91	111	25	.	.	.
cord-015910-d9gxew91	112	1	Alleles	allele	NNS
cord-015910-d9gxew91	112	2	1	1	CD
cord-015910-d9gxew91	112	3	,	,	,
cord-015910-d9gxew91	112	4	2	2	CD
cord-015910-d9gxew91	112	5	,	,	,
cord-015910-d9gxew91	112	6	and	and	CC
cord-015910-d9gxew91	112	7	4	4	CD
cord-015910-d9gxew91	112	8	are	be	VBP
cord-015910-d9gxew91	112	9	poor	poor	JJ
cord-015910-d9gxew91	112	10	promoters	promoter	NNS
cord-015910-d9gxew91	112	11	,	,	,
cord-015910-d9gxew91	112	12	whereas	whereas	IN
cord-015910-d9gxew91	112	13	allele	allele	NN
cord-015910-d9gxew91	112	14	3	3	CD
cord-015910-d9gxew91	112	15	causes	cause	VBZ
cord-015910-d9gxew91	112	16	high	high	JJ
cord-015910-d9gxew91	112	17	gene	gene	NN
cord-015910-d9gxew91	112	18	expression	expression	NN
cord-015910-d9gxew91	112	19	.	.	.
cord-015910-d9gxew91	113	1	Hyperactivity	hyperactivity	NN
cord-015910-d9gxew91	113	2	of	of	IN
cord-015910-d9gxew91	113	3	macrophages	macrophage	NNS
cord-015910-d9gxew91	113	4	,	,	,
cord-015910-d9gxew91	113	5	associated	associate	VBN
cord-015910-d9gxew91	113	6	with	with	IN
cord-015910-d9gxew91	113	7	allele	allele	NN
cord-015910-d9gxew91	113	8	3	3	CD
cord-015910-d9gxew91	113	9	,	,	,
cord-015910-d9gxew91	113	10	is	be	VBZ
cord-015910-d9gxew91	113	11	linked	link	VBN
cord-015910-d9gxew91	113	12	to	to	IN
cord-015910-d9gxew91	113	13	autoimmune	autoimmune	JJ
cord-015910-d9gxew91	113	14	disease	disease	NN
cord-015910-d9gxew91	113	15	susceptibility	susceptibility	NN
cord-015910-d9gxew91	113	16	and	and	CC
cord-015910-d9gxew91	113	17	high	high	JJ
cord-015910-d9gxew91	113	18	resistance	resistance	NN
cord-015910-d9gxew91	113	19	to	to	IN
cord-015910-d9gxew91	113	20	infection	infection	NN
cord-015910-d9gxew91	113	21	,	,	,
cord-015910-d9gxew91	113	22	whereas	whereas	IN
cord-015910-d9gxew91	113	23	allele	allele	NN
cord-015910-d9gxew91	113	24	2	2	CD
cord-015910-d9gxew91	113	25	increases	increase	VBZ
cord-015910-d9gxew91	113	26	susceptibility	susceptibility	NN
cord-015910-d9gxew91	113	27	to	to	IN
cord-015910-d9gxew91	113	28	infection	infection	NN
cord-015910-d9gxew91	113	29	and	and	CC
cord-015910-d9gxew91	113	30	protects	protect	VBZ
cord-015910-d9gxew91	113	31	against	against	IN
cord-015910-d9gxew91	113	32	autoimmune	autoimmune	JJ
cord-015910-d9gxew91	113	33	disease	disease	NN
cord-015910-d9gxew91	113	34	(	(	-LRB-
cord-015910-d9gxew91	113	35	Searle	Searle	NNP
cord-015910-d9gxew91	113	36	&	&	CC
cord-015910-d9gxew91	113	37	Blackwell	Blackwell	NNP
cord-015910-d9gxew91	113	38	,	,	,
cord-015910-d9gxew91	113	39	1999	1999	CD
cord-015910-d9gxew91	113	40	)	)	-RRB-
cord-015910-d9gxew91	113	41	.	.	.
cord-015910-d9gxew91	114	1	As	as	IN
cord-015910-d9gxew91	114	2	indicated	indicate	VBN
cord-015910-d9gxew91	114	3	earlier	early	RBR
cord-015910-d9gxew91	114	4	,	,	,
cord-015910-d9gxew91	114	5	a	a	DT
cord-015910-d9gxew91	114	6	number	number	NN
cord-015910-d9gxew91	114	7	of	of	IN
cord-015910-d9gxew91	114	8	molecules	molecule	NNS
cord-015910-d9gxew91	114	9	suppress	suppress	VBP
cord-015910-d9gxew91	114	10	production	production	NN
cord-015910-d9gxew91	114	11	of	of	IN
cord-015910-d9gxew91	114	12	pro	pro	JJ
cord-015910-d9gxew91	114	13	-	-	JJ
cord-015910-d9gxew91	114	14	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	114	15	cytokines	cytokine	NNS
cord-015910-d9gxew91	114	16	and	and	CC
cord-015910-d9gxew91	114	17	exert	exert	VB
cord-015910-d9gxew91	114	18	an	an	DT
cord-015910-d9gxew91	114	19	anti	anti	JJ
cord-015910-d9gxew91	114	20	-	-	JJ
cord-015910-d9gxew91	114	21	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	114	22	influence	influence	NN
cord-015910-d9gxew91	114	23	.	.	.
cord-015910-d9gxew91	115	1	These	these	DT
cord-015910-d9gxew91	115	2	include	include	VBP
cord-015910-d9gxew91	115	3	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	115	4	defenses	defense	NNS
cord-015910-d9gxew91	115	5	and	and	CC
cord-015910-d9gxew91	115	6	IL-10	IL-10	NNP
cord-015910-d9gxew91	115	7	(	(	-LRB-
cord-015910-d9gxew91	115	8	Chernoff	Chernoff	NNP
cord-015910-d9gxew91	115	9	et	et	NNP
cord-015910-d9gxew91	115	10	al	al	NNP
cord-015910-d9gxew91	115	11	.	.	NNP
cord-015910-d9gxew91	115	12	,	,	,
cord-015910-d9gxew91	115	13	1995	1995	CD
cord-015910-d9gxew91	115	14	;	;	:
cord-015910-d9gxew91	115	15	Espevik	Espevik	NNP
cord-015910-d9gxew91	115	16	et	et	NNP
cord-015910-d9gxew91	115	17	al	al	NNP
cord-015910-d9gxew91	115	18	.	.	NNP
cord-015910-d9gxew91	115	19	,	,	,
cord-015910-d9gxew91	115	20	1987	1987	CD
cord-015910-d9gxew91	115	21	)	)	-RRB-
cord-015910-d9gxew91	115	22	.	.	.
cord-015910-d9gxew91	116	1	Production	production	NN
cord-015910-d9gxew91	116	2	is	be	VBZ
cord-015910-d9gxew91	116	3	modulated	modulate	VBN
cord-015910-d9gxew91	116	4	by	by	IN
cord-015910-d9gxew91	116	5	genetic	genetic	JJ
cord-015910-d9gxew91	116	6	factors	factor	NNS
cord-015910-d9gxew91	116	7	.	.	.
cord-015910-d9gxew91	117	1	There	there	EX
cord-015910-d9gxew91	117	2	are	be	VBP
cord-015910-d9gxew91	117	3	at	at	RB
cord-015910-d9gxew91	117	4	least	least	RBS
cord-015910-d9gxew91	117	5	three	three	CD
cord-015910-d9gxew91	117	6	polymorphic	polymorphic	JJ
cord-015910-d9gxew91	117	7	sites	site	NNS
cord-015910-d9gxew91	117	8	(	(	-LRB-
cord-015910-d9gxew91	117	9	-1082	-1082	:
cord-015910-d9gxew91	117	10	,	,	,
cord-015910-d9gxew91	117	11	-819	-819	XX
cord-015910-d9gxew91	117	12	,	,	,
cord-015910-d9gxew91	117	13	-592	-592	NNP
cord-015910-d9gxew91	117	14	)	)	-RRB-
cord-015910-d9gxew91	117	15	in	in	IN
cord-015910-d9gxew91	117	16	the	the	DT
cord-015910-d9gxew91	117	17	IL	IL	NNP
cord-015910-d9gxew91	117	18	-	-	HYPH
cord-015910-d9gxew91	117	19	l0	l0	NNP
cord-015910-d9gxew91	117	20	promoter	promoter	NN
cord-015910-d9gxew91	117	21	that	that	WDT
cord-015910-d9gxew91	117	22	influence	influence	NN
cord-015910-d9gxew91	117	23	production	production	NN
cord-015910-d9gxew91	117	24	(	(	-LRB-
cord-015910-d9gxew91	117	25	Perrey	Perrey	NNP
cord-015910-d9gxew91	117	26	,	,	,
cord-015910-d9gxew91	117	27	Pravice	Pravice	NNP
cord-015910-d9gxew91	117	28	,	,	,
cord-015910-d9gxew91	117	29	Sinnott	Sinnott	NNP
cord-015910-d9gxew91	117	30	,	,	,
cord-015910-d9gxew91	117	31	&	&	CC
cord-015910-d9gxew91	117	32	Hutchinson	Hutchinson	NNP
cord-015910-d9gxew91	117	33	,	,	,
cord-015910-d9gxew91	117	34	1998	1998	CD
cord-015910-d9gxew91	117	35	)	)	-RRB-
cord-015910-d9gxew91	117	36	.	.	.
cord-015910-d9gxew91	118	1	SNPs	SNPs	NNP
cord-015910-d9gxew91	118	2	also	also	RB
cord-015910-d9gxew91	118	3	occur	occur	VBP
cord-015910-d9gxew91	118	4	in	in	IN
cord-015910-d9gxew91	118	5	genes	gene	NNS
cord-015910-d9gxew91	118	6	encoding	encode	VBG
cord-015910-d9gxew91	118	7	enzymatic	enzymatic	JJ
cord-015910-d9gxew91	118	8	components	component	NNS
cord-015910-d9gxew91	118	9	of	of	IN
cord-015910-d9gxew91	118	10	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	118	11	defenses	defense	NNS
cord-015910-d9gxew91	118	12	,	,	,
cord-015910-d9gxew91	118	13	such	such	JJ
cord-015910-d9gxew91	118	14	as	as	IN
cord-015910-d9gxew91	118	15	catalase	catalase	NN
cord-015910-d9gxew91	118	16	,	,	,
cord-015910-d9gxew91	118	17	SOD	SOD	NNP
cord-015910-d9gxew91	118	18	,	,	,
cord-015910-d9gxew91	118	19	and	and	CC
cord-015910-d9gxew91	118	20	GSH	GSH	NNP
cord-015910-d9gxew91	118	21	peroxidase	peroxidase	NN
cord-015910-d9gxew91	118	22	,	,	,
cord-015910-d9gxew91	118	23	which	which	WDT
cord-015910-d9gxew91	118	24	influence	influence	NN
cord-015910-d9gxew91	118	25	levels	level	NNS
cord-015910-d9gxew91	118	26	of	of	IN
cord-015910-d9gxew91	118	27	activity	activity	NN
cord-015910-d9gxew91	118	28	(	(	-LRB-
cord-015910-d9gxew91	118	29	Chorazy	Chorazy	NNP
cord-015910-d9gxew91	118	30	,	,	,
cord-015910-d9gxew91	118	31	Schumacher	Schumacher	NNP
cord-015910-d9gxew91	118	32	,	,	,
cord-015910-d9gxew91	118	33	&	&	CC
cord-015910-d9gxew91	118	34	Edlind	Edlind	NNP
cord-015910-d9gxew91	118	35	,	,	,
cord-015910-d9gxew91	118	36	1992	1992	CD
cord-015910-d9gxew91	118	37	;	;	:
cord-015910-d9gxew91	118	38	Forsberg	Forsberg	NNP
cord-015910-d9gxew91	118	39	,	,	,
cord-015910-d9gxew91	118	40	Lyrenas	Lyrenas	NNP
cord-015910-d9gxew91	118	41	,	,	,
cord-015910-d9gxew91	118	42	de	de	NNP
cord-015910-d9gxew91	118	43	Faire	Faire	NNP
cord-015910-d9gxew91	118	44	,	,	,
cord-015910-d9gxew91	118	45	&	&	CC
cord-015910-d9gxew91	118	46	Morgenstern	Morgenstern	NNP
cord-015910-d9gxew91	118	47	,	,	,
cord-015910-d9gxew91	118	48	2001	2001	CD
cord-015910-d9gxew91	118	49	;	;	:
cord-015910-d9gxew91	118	50	Mitrunen	Mitrunen	NNP
cord-015910-d9gxew91	118	51	et	et	FW
cord-015910-d9gxew91	118	52	al	al	NNP
cord-015910-d9gxew91	118	53	.	.	NNP
cord-015910-d9gxew91	118	54	,	,	,
cord-015910-d9gxew91	118	55	2001	2001	CD
cord-015910-d9gxew91	118	56	)	)	-RRB-
cord-015910-d9gxew91	118	57	.	.	.
cord-015910-d9gxew91	119	1	There	there	EX
cord-015910-d9gxew91	119	2	is	be	VBZ
cord-015910-d9gxew91	119	3	circumstantial	circumstantial	JJ
cord-015910-d9gxew91	119	4	evidence	evidence	NN
cord-015910-d9gxew91	119	5	,	,	,
cord-015910-d9gxew91	119	6	that	that	IN
cord-015910-d9gxew91	119	7	at	at	IN
cord-015910-d9gxew91	119	8	an	an	DT
cord-015910-d9gxew91	119	9	individual	individual	JJ
cord-015910-d9gxew91	119	10	level	level	NN
cord-015910-d9gxew91	119	11	,	,	,
cord-015910-d9gxew91	119	12	an	an	DT
cord-015910-d9gxew91	119	13	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	119	14	genotype	genotype	NN
cord-015910-d9gxew91	119	15	exists	exist	VBZ
cord-015910-d9gxew91	119	16	that	that	WDT
cord-015910-d9gxew91	119	17	can	can	MD
cord-015910-d9gxew91	119	18	adversely	adversely	RB
cord-015910-d9gxew91	119	19	effect	effect	VB
cord-015910-d9gxew91	119	20	the	the	DT
cord-015910-d9gxew91	119	21	host	host	NN
cord-015910-d9gxew91	119	22	.	.	.
cord-015910-d9gxew91	120	1	In	in	IN
cord-015910-d9gxew91	120	2	a	a	DT
cord-015910-d9gxew91	120	3	study	study	NN
cord-015910-d9gxew91	120	4	of	of	IN
cord-015910-d9gxew91	120	5	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	120	6	lung	lung	NN
cord-015910-d9gxew91	120	7	disease	disease	NN
cord-015910-d9gxew91	120	8	caused	cause	VBN
cord-015910-d9gxew91	120	9	by	by	IN
cord-015910-d9gxew91	120	10	exposure	exposure	NN
cord-015910-d9gxew91	120	11	to	to	IN
cord-015910-d9gxew91	120	12	coal	coal	NN
cord-015910-d9gxew91	120	13	dust	dust	NN
cord-015910-d9gxew91	120	14	,	,	.
cord-015910-d9gxew91	121	1	the	the	DT
cord-015910-d9gxew91	121	2	TNF2	TNF2	NNP
cord-015910-d9gxew91	121	3	(	(	-LRB-
cord-015910-d9gxew91	121	4	LT	LT	NNP
cord-015910-d9gxew91	121	5	-	-	HYPH
cord-015910-d9gxew91	121	6	a+252	a+252	NNP
cord-015910-d9gxew91	121	7	A	A	NNP
cord-015910-d9gxew91	121	8	)	)	-RRB-
cord-015910-d9gxew91	121	9	allele	allele	NN
cord-015910-d9gxew91	121	10	was	be	VBD
cord-015910-d9gxew91	121	11	almost	almost	RB
cord-015910-d9gxew91	121	12	twice	twice	RB
cord-015910-d9gxew91	121	13	as	as	RB
cord-015910-d9gxew91	121	14	common	common	JJ
cord-015910-d9gxew91	121	15	in	in	IN
cord-015910-d9gxew91	121	16	miners	miner	NNS
cord-015910-d9gxew91	121	17	with	with	IN
cord-015910-d9gxew91	121	18	the	the	DT
cord-015910-d9gxew91	121	19	disease	disease	NN
cord-015910-d9gxew91	121	20	than	than	IN
cord-015910-d9gxew91	121	21	in	in	IN
cord-015910-d9gxew91	121	22	those	those	DT
cord-015910-d9gxew91	121	23	who	who	WP
cord-015910-d9gxew91	121	24	were	be	VBD
cord-015910-d9gxew91	121	25	healthy	healthy	JJ
cord-015910-d9gxew91	121	26	(	(	-LRB-
cord-015910-d9gxew91	121	27	Zhai	Zhai	NNP
cord-015910-d9gxew91	121	28	,	,	,
cord-015910-d9gxew91	121	29	Jetten	Jetten	NNP
cord-015910-d9gxew91	121	30	,	,	,
cord-015910-d9gxew91	121	31	Schins	Schins	NNP
cord-015910-d9gxew91	121	32	,	,	,
cord-015910-d9gxew91	121	33	Franssen	Franssen	NNP
cord-015910-d9gxew91	121	34	,	,	,
cord-015910-d9gxew91	121	35	&	&	CC
cord-015910-d9gxew91	121	36	Borm	Borm	NNP
cord-015910-d9gxew91	121	37	,	,	,
cord-015910-d9gxew91	121	38	1998	1998	CD
cord-015910-d9gxew91	121	39	)	)	-RRB-
cord-015910-d9gxew91	121	40	.	.	.
cord-015910-d9gxew91	122	1	Development	development	NN
cord-015910-d9gxew91	122	2	of	of	IN
cord-015910-d9gxew91	122	3	farmer	farmer	NN
cord-015910-d9gxew91	122	4	's	's	POS
cord-015910-d9gxew91	122	5	lung	lung	NN
cord-015910-d9gxew91	122	6	from	from	IN
cord-015910-d9gxew91	122	7	exposure	exposure	NN
cord-015910-d9gxew91	122	8	to	to	IN
cord-015910-d9gxew91	122	9	hay	hay	NN
cord-015910-d9gxew91	122	10	dust	dust	NN
cord-015910-d9gxew91	122	11	was	be	VBD
cord-015910-d9gxew91	122	12	80	80	CD
cord-015910-d9gxew91	122	13	%	%	NN
cord-015910-d9gxew91	122	14	greater	great	JJR
cord-015910-d9gxew91	122	15	in	in	IN
cord-015910-d9gxew91	122	16	individuals	individual	NNS
cord-015910-d9gxew91	122	17	with	with	IN
cord-015910-d9gxew91	122	18	the	the	DT
cord-015910-d9gxew91	122	19	TNF2	tnf2	CD
cord-015910-d9gxew91	122	20	allele	allele	NN
cord-015910-d9gxew91	122	21	than	than	IN
cord-015910-d9gxew91	122	22	in	in	IN
cord-015910-d9gxew91	122	23	those	those	DT
cord-015910-d9gxew91	122	24	without	without	IN
cord-015910-d9gxew91	122	25	the	the	DT
cord-015910-d9gxew91	122	26	allele	allele	NN
cord-015910-d9gxew91	122	27	(	(	-LRB-
cord-015910-d9gxew91	122	28	Schaaf	Schaaf	NNP
cord-015910-d9gxew91	122	29	,	,	,
cord-015910-d9gxew91	122	30	Seitzer	Seitzer	NNP
cord-015910-d9gxew91	122	31	,	,	,
cord-015910-d9gxew91	122	32	Pravica	Pravica	NNP
cord-015910-d9gxew91	122	33	,	,	,
cord-015910-d9gxew91	122	34	Aries	Aries	NNP
cord-015910-d9gxew91	122	35	,	,	,
cord-015910-d9gxew91	122	36	&	&	CC
cord-015910-d9gxew91	122	37	Zabel	Zabel	NNP
cord-015910-d9gxew91	122	38	,	,	,
cord-015910-d9gxew91	122	39	2001	2001	CD
cord-015910-d9gxew91	122	40	)	)	-RRB-
cord-015910-d9gxew91	122	41	.	.	.
cord-015910-d9gxew91	123	1	The	the	DT
cord-015910-d9gxew91	123	2	TNF2	tnf2	CD
cord-015910-d9gxew91	123	3	allele	allele	NN
cord-015910-d9gxew91	123	4	was	be	VBD
cord-015910-d9gxew91	123	5	also	also	RB
cord-015910-d9gxew91	123	6	twice	twice	RB
cord-015910-d9gxew91	123	7	as	as	RB
cord-015910-d9gxew91	123	8	common	common	JJ
cord-015910-d9gxew91	123	9	in	in	IN
cord-015910-d9gxew91	123	10	smokers	smoker	NNS
cord-015910-d9gxew91	123	11	who	who	WP
cord-015910-d9gxew91	123	12	developed	develop	VBD
cord-015910-d9gxew91	123	13	chronic	chronic	JJ
cord-015910-d9gxew91	123	14	obstructive	obstructive	JJ
cord-015910-d9gxew91	123	15	pulmonary	pulmonary	JJ
cord-015910-d9gxew91	123	16	disease	disease	NN
cord-015910-d9gxew91	123	17	than	than	IN
cord-015910-d9gxew91	123	18	in	in	IN
cord-015910-d9gxew91	123	19	those	those	DT
cord-015910-d9gxew91	123	20	who	who	WP
cord-015910-d9gxew91	123	21	remained	remain	VBD
cord-015910-d9gxew91	123	22	disease	disease	NN
cord-015910-d9gxew91	123	23	-	-	HYPH
cord-015910-d9gxew91	123	24	free	free	JJ
cord-015910-d9gxew91	123	25	(	(	-LRB-
cord-015910-d9gxew91	123	26	Sakao	Sakao	NNP
cord-015910-d9gxew91	123	27	et	et	NNP
cord-015910-d9gxew91	123	28	al	al	NNP
cord-015910-d9gxew91	123	29	.	.	NNP
cord-015910-d9gxew91	123	30	,	,	,
cord-015910-d9gxew91	123	31	2001	2001	CD
cord-015910-d9gxew91	123	32	)	)	-RRB-
cord-015910-d9gxew91	123	33	.	.	.
cord-015910-d9gxew91	124	1	In	in	IN
cord-015910-d9gxew91	124	2	addition	addition	NN
cord-015910-d9gxew91	124	3	to	to	IN
cord-015910-d9gxew91	124	4	disease	disease	NN
cord-015910-d9gxew91	124	5	progression	progression	NN
cord-015910-d9gxew91	124	6	,	,	,
cord-015910-d9gxew91	124	7	genetic	genetic	JJ
cord-015910-d9gxew91	124	8	factors	factor	NNS
cord-015910-d9gxew91	124	9	have	have	VBP
cord-015910-d9gxew91	124	10	important	important	JJ
cord-015910-d9gxew91	124	11	effects	effect	NNS
cord-015910-d9gxew91	124	12	on	on	IN
cord-015910-d9gxew91	124	13	mortality	mortality	NN
cord-015910-d9gxew91	124	14	and	and	CC
cord-015910-d9gxew91	124	15	morbidity	morbidity	NN
cord-015910-d9gxew91	124	16	in	in	IN
cord-015910-d9gxew91	124	17	infectious	infectious	JJ
cord-015910-d9gxew91	124	18	and	and	CC
cord-015910-d9gxew91	124	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	124	20	disease	disease	NN
cord-015910-d9gxew91	124	21	.	.	.
cord-015910-d9gxew91	125	1	During	during	IN
cord-015910-d9gxew91	125	2	malaria	malaria	NN
cord-015910-d9gxew91	125	3	,	,	,
cord-015910-d9gxew91	125	4	children	child	NNS
cord-015910-d9gxew91	125	5	who	who	WP
cord-015910-d9gxew91	125	6	were	be	VBD
cord-015910-d9gxew91	125	7	homozygous	homozygous	JJ
cord-015910-d9gxew91	125	8	for	for	IN
cord-015910-d9gxew91	125	9	TNF2	TNF2	NNP
cord-015910-d9gxew91	125	10	had	have	VBD
cord-015910-d9gxew91	125	11	a	a	DT
cord-015910-d9gxew91	125	12	sevenfold	sevenfold	NNP
cord-015910-d9gxew91	125	13	greater	great	JJR
cord-015910-d9gxew91	125	14	risk	risk	NN
cord-015910-d9gxew91	125	15	of	of	IN
cord-015910-d9gxew91	125	16	death	death	NN
cord-015910-d9gxew91	125	17	or	or	CC
cord-015910-d9gxew91	125	18	serious	serious	JJ
cord-015910-d9gxew91	125	19	pathology	pathology	NN
cord-015910-d9gxew91	125	20	than	than	IN
cord-015910-d9gxew91	125	21	children	child	NNS
cord-015910-d9gxew91	125	22	who	who	WP
cord-015910-d9gxew91	125	23	were	be	VBD
cord-015910-d9gxew91	125	24	homozygous	homozygous	JJ
cord-015910-d9gxew91	125	25	for	for	IN
cord-015910-d9gxew91	125	26	the	the	DT
cord-015910-d9gxew91	125	27	TNF1	TNF1	NNP
cord-015910-d9gxew91	125	28	allele	allele	NN
cord-015910-d9gxew91	125	29	(	(	-LRB-
cord-015910-d9gxew91	125	30	McGuire	McGuire	NNP
cord-015910-d9gxew91	125	31	,	,	,
cord-015910-d9gxew91	125	32	Hill	Hill	NNP
cord-015910-d9gxew91	125	33	,	,	,
cord-015910-d9gxew91	125	34	Allsopp	Allsopp	NNP
cord-015910-d9gxew91	125	35	,	,	,
cord-015910-d9gxew91	125	36	Greenwood	Greenwood	NNP
cord-015910-d9gxew91	125	37	,	,	,
cord-015910-d9gxew91	125	38	&	&	CC
cord-015910-d9gxew91	125	39	Kwiatkowski	Kwiatkowski	NNP
cord-015910-d9gxew91	125	40	,	,	,
cord-015910-d9gxew91	125	41	1994	1994	CD
cord-015910-d9gxew91	125	42	)	)	-RRB-
cord-015910-d9gxew91	125	43	.	.	.
cord-015910-d9gxew91	126	1	In	in	IN
cord-015910-d9gxew91	126	2	intensive	intensive	JJ
cord-015910-d9gxew91	126	3	-	-	HYPH
cord-015910-d9gxew91	126	4	care	care	NN
cord-015910-d9gxew91	126	5	patients	patient	NNS
cord-015910-d9gxew91	126	6	the	the	DT
cord-015910-d9gxew91	126	7	occurrence	occurrence	NN
cord-015910-d9gxew91	126	8	of	of	IN
cord-015910-d9gxew91	126	9	1082"G	1082"g	CD
cord-015910-d9gxew91	126	10	high	high	RB
cord-015910-d9gxew91	126	11	-	-	HYPH
cord-015910-d9gxew91	126	12	producing	produce	VBG
cord-015910-d9gxew91	126	13	allele	allele	NN
cord-015910-d9gxew91	126	14	for	for	IN
cord-015910-d9gxew91	126	15	IL-10	IL-10	NNP
cord-015910-d9gxew91	126	16	was	be	VBD
cord-015910-d9gxew91	126	17	present	present	JJ
cord-015910-d9gxew91	126	18	in	in	IN
cord-015910-d9gxew91	126	19	those	those	DT
cord-015910-d9gxew91	126	20	who	who	WP
cord-015910-d9gxew91	126	21	developed	develop	VBD
cord-015910-d9gxew91	126	22	multiorgan	multiorgan	NN
cord-015910-d9gxew91	126	23	failure	failure	NN
cord-015910-d9gxew91	126	24	with	with	IN
cord-015910-d9gxew91	126	25	a	a	DT
cord-015910-d9gxew91	126	26	frequency	frequency	NN
cord-015910-d9gxew91	126	27	of	of	IN
cord-015910-d9gxew91	126	28	one	one	CD
cord-015910-d9gxew91	126	29	-	-	HYPH
cord-015910-d9gxew91	126	30	fifth	fifth	NN
cord-015910-d9gxew91	126	31	of	of	IN
cord-015910-d9gxew91	126	32	that	that	DT
cord-015910-d9gxew91	126	33	of	of	IN
cord-015910-d9gxew91	126	34	the	the	DT
cord-015910-d9gxew91	126	35	normal	normal	JJ
cord-015910-d9gxew91	126	36	population	population	NN
cord-015910-d9gxew91	126	37	(	(	-LRB-
cord-015910-d9gxew91	126	38	Reid	Reid	NNP
cord-015910-d9gxew91	126	39	,	,	,
cord-015910-d9gxew91	126	40	Hutchinson	Hutchinson	NNP
cord-015910-d9gxew91	126	41	,	,	,
cord-015910-d9gxew91	126	42	Campbell	Campbell	NNP
cord-015910-d9gxew91	126	43	,	,	,
cord-015910-d9gxew91	126	44	&	&	CC
cord-015910-d9gxew91	126	45	Little	Little	NNP
cord-015910-d9gxew91	126	46	,	,	,
cord-015910-d9gxew91	126	47	1999	1999	CD
cord-015910-d9gxew91	126	48	)	)	-RRB-
cord-015910-d9gxew91	126	49	.	.	.
cord-015910-d9gxew91	127	1	In	in	IN
cord-015910-d9gxew91	127	2	sepsis	sepsis	NN
cord-015910-d9gxew91	127	3	,	,	,
cord-015910-d9gxew91	127	4	patients	patient	NNS
cord-015910-d9gxew91	127	5	possessing	possess	VBG
cord-015910-d9gxew91	127	6	the	the	DT
cord-015910-d9gxew91	127	7	TNF2	tnf2	CD
cord-015910-d9gxew91	127	8	allele	allele	NN
cord-015910-d9gxew91	127	9	had	have	VBD
cord-015910-d9gxew91	127	10	a	a	DT
cord-015910-d9gxew91	127	11	3.7-fold	3.7-fold	CD
cord-015910-d9gxew91	127	12	greater	great	JJR
cord-015910-d9gxew91	127	13	risk	risk	NN
cord-015910-d9gxew91	127	14	of	of	IN
cord-015910-d9gxew91	127	15	death	death	NN
cord-015910-d9gxew91	127	16	than	than	IN
cord-015910-d9gxew91	127	17	those	those	DT
cord-015910-d9gxew91	127	18	without	without	IN
cord-015910-d9gxew91	127	19	the	the	DT
cord-015910-d9gxew91	127	20	allele	allele	NN
cord-015910-d9gxew91	127	21	,	,	,
cord-015910-d9gxew91	127	22	and	and	CC
cord-015910-d9gxew91	127	23	patients	patient	NNS
cord-015910-d9gxew91	127	24	who	who	WP
cord-015910-d9gxew91	127	25	were	be	VBD
cord-015910-d9gxew91	127	26	homozygous	homozygous	JJ
cord-015910-d9gxew91	127	27	for	for	IN
cord-015910-d9gxew91	127	28	the	the	DT
cord-015910-d9gxew91	127	29	LT-~	LT-~	NNP
cord-015910-d9gxew91	127	30	+	+	SYM
cord-015910-d9gxew91	127	31	252	252	CD
cord-015910-d9gxew91	127	32	A	a	DT
cord-015910-d9gxew91	127	33	allele	allele	NN
cord-015910-d9gxew91	127	34	had	have	VBD
cord-015910-d9gxew91	127	35	twice	twice	PDT
cord-015910-d9gxew91	127	36	the	the	DT
cord-015910-d9gxew91	127	37	mortality	mortality	NN
cord-015910-d9gxew91	127	38	rate	rate	NN
cord-015910-d9gxew91	127	39	and	and	CC
cord-015910-d9gxew91	127	40	higher	high	JJR
cord-015910-d9gxew91	127	41	peak	peak	NN
cord-015910-d9gxew91	127	42	plasma	plasma	NN
cord-015910-d9gxew91	127	43	TNF	TNF	NNP
cord-015910-d9gxew91	127	44	-	-	HYPH
cord-015910-d9gxew91	127	45	ot	ot	NNP
cord-015910-d9gxew91	127	46	concentrations	concentration	NNS
cord-015910-d9gxew91	127	47	than	than	IN
cord-015910-d9gxew91	127	48	heterozygotic	heterozygotic	JJ
cord-015910-d9gxew91	127	49	individuals	individual	NNS
cord-015910-d9gxew91	127	50	(	(	-LRB-
cord-015910-d9gxew91	127	51	Mira	Mira	NNP
cord-015910-d9gxew91	127	52	et	et	NNP
cord-015910-d9gxew91	127	53	al	al	NNP
cord-015910-d9gxew91	127	54	.	.	NNP
cord-015910-d9gxew91	127	55	,	,	,
cord-015910-d9gxew91	127	56	1999	1999	CD
cord-015910-d9gxew91	127	57	;	;	:
cord-015910-d9gxew91	127	58	Stuber	Stuber	NNP
cord-015910-d9gxew91	127	59	,	,	,
cord-015910-d9gxew91	127	60	Peterson	Peterson	NNP
cord-015910-d9gxew91	127	61	,	,	,
cord-015910-d9gxew91	127	62	Bokelmann	Bokelmann	NNP
cord-015910-d9gxew91	127	63	,	,	,
cord-015910-d9gxew91	127	64	&	&	CC
cord-015910-d9gxew91	127	65	Schade	Schade	NNP
cord-015910-d9gxew91	127	66	,	,	,
cord-015910-d9gxew91	127	67	1996	1996	CD
cord-015910-d9gxew91	127	68	)	)	-RRB-
cord-015910-d9gxew91	127	69	.	.	.
cord-015910-d9gxew91	128	1	The	the	DT
cord-015910-d9gxew91	128	2	TNF2	TNF2	NNP
cord-015910-d9gxew91	128	3	allele	allele	NN
cord-015910-d9gxew91	128	4	also	also	RB
cord-015910-d9gxew91	128	5	been	be	VBN
cord-015910-d9gxew91	128	6	found	find	VBN
cord-015910-d9gxew91	128	7	in	in	IN
cord-015910-d9gxew91	128	8	increased	increase	VBN
cord-015910-d9gxew91	128	9	frequencies	frequency	NNS
cord-015910-d9gxew91	128	10	in	in	IN
cord-015910-d9gxew91	128	11	systemic	systemic	JJ
cord-015910-d9gxew91	128	12	lupus	lupus	NN
cord-015910-d9gxew91	128	13	erythromatosus	erythromatosus	NN
cord-015910-d9gxew91	128	14	,	,	,
cord-015910-d9gxew91	128	15	dermatitis	dermatitis	NNP
cord-015910-d9gxew91	128	16	hepetiformis	hepetiformis	NNP
cord-015910-d9gxew91	128	17	,	,	,
cord-015910-d9gxew91	128	18	and	and	CC
cord-015910-d9gxew91	128	19	insulin	insulin	NN
cord-015910-d9gxew91	128	20	-	-	HYPH
cord-015910-d9gxew91	128	21	dependent	dependent	JJ
cord-015910-d9gxew91	128	22	diabetes	diabetes	NN
cord-015910-d9gxew91	128	23	mellitus	mellitus	NN
cord-015910-d9gxew91	128	24	and	and	CC
cord-015910-d9gxew91	128	25	noninsulin	noninsulin	JJ
cord-015910-d9gxew91	128	26	-	-	JJ
cord-015910-d9gxew91	128	27	dependent	dependent	JJ
cord-015910-d9gxew91	128	28	diabetes	diabetes	NN
cord-015910-d9gxew91	128	29	mellitus	mellitus	NN
cord-015910-d9gxew91	128	30	(	(	-LRB-
cord-015910-d9gxew91	128	31	NIDDM	NIDDM	NNP
cord-015910-d9gxew91	128	32	)	)	-RRB-
cord-015910-d9gxew91	128	33	(	(	-LRB-
cord-015910-d9gxew91	128	34	Jacob	Jacob	NNP
cord-015910-d9gxew91	128	35	et	et	NNP
cord-015910-d9gxew91	128	36	al	al	NNP
cord-015910-d9gxew91	128	37	.	.	.
cord-015910-d9gxew91	129	1	,	,	,
cord-015910-d9gxew91	129	2	1990	1990	CD
cord-015910-d9gxew91	129	3	,	,	,
cord-015910-d9gxew91	129	4	Wilson	Wilson	NNP
cord-015910-d9gxew91	129	5	,	,	,
cord-015910-d9gxew91	129	6	Clay	Clay	NNP
cord-015910-d9gxew91	129	7	,	,	,
cord-015910-d9gxew91	129	8	&	&	CC
cord-015910-d9gxew91	129	9	Crane	Crane	NNP
cord-015910-d9gxew91	129	10	,	,	,
cord-015910-d9gxew91	129	11	1995	1995	CD
cord-015910-d9gxew91	129	12	Wilson	Wilson	NNP
cord-015910-d9gxew91	129	13	,	,	,
cord-015910-d9gxew91	129	14	Gordon	Gordon	NNP
cord-015910-d9gxew91	129	15	,	,	,
cord-015910-d9gxew91	129	16	&	&	CC
cord-015910-d9gxew91	129	17	di	di	FW
cord-015910-d9gxew91	129	18	Giovine	Giovine	NNP
cord-015910-d9gxew91	129	19	,	,	,
cord-015910-d9gxew91	129	20	1994	1994	CD
cord-015910-d9gxew91	129	21	)	)	-RRB-
cord-015910-d9gxew91	129	22	.	.	.
cord-015910-d9gxew91	130	1	Thus	thus	RB
cord-015910-d9gxew91	130	2	,	,	,
cord-015910-d9gxew91	130	3	it	-PRON-	PRP
cord-015910-d9gxew91	130	4	now	now	RB
cord-015910-d9gxew91	130	5	appears	appear	VBZ
cord-015910-d9gxew91	130	6	that	that	IN
cord-015910-d9gxew91	130	7	each	each	DT
cord-015910-d9gxew91	130	8	individual	individual	NN
cord-015910-d9gxew91	130	9	possesses	possess	VBZ
cord-015910-d9gxew91	130	10	combinations	combination	NNS
cord-015910-d9gxew91	130	11	of	of	IN
cord-015910-d9gxew91	130	12	SNPs	snp	NNS
cord-015910-d9gxew91	130	13	in	in	IN
cord-015910-d9gxew91	130	14	their	-PRON-	PRP$
cord-015910-d9gxew91	130	15	genes	gene	NNS
cord-015910-d9gxew91	130	16	associated	associate	VBN
cord-015910-d9gxew91	130	17	with	with	IN
cord-015910-d9gxew91	130	18	inflammation	inflammation	NN
cord-015910-d9gxew91	130	19	corresponding	correspond	VBG
cord-015910-d9gxew91	130	20	to	to	IN
cord-015910-d9gxew91	130	21	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	130	22	drives	drive	NNS
cord-015910-d9gxew91	130	23	of	of	IN
cord-015910-d9gxew91	130	24	differing	differ	VBG
cord-015910-d9gxew91	130	25	intensities	intensity	NNS
cord-015910-d9gxew91	130	26	when	when	WRB
cord-015910-d9gxew91	130	27	microbes	microbe	NNS
cord-015910-d9gxew91	130	28	or	or	CC
cord-015910-d9gxew91	130	29	tissue	tissue	NN
cord-015910-d9gxew91	130	30	injury	injury	NN
cord-015910-d9gxew91	130	31	are	be	VBP
cord-015910-d9gxew91	130	32	encountered	encounter	VBN
cord-015910-d9gxew91	130	33	.	.	.
cord-015910-d9gxew91	131	1	At	at	IN
cord-015910-d9gxew91	131	2	an	an	DT
cord-015910-d9gxew91	131	3	individual	individual	JJ
cord-015910-d9gxew91	131	4	level	level	NN
cord-015910-d9gxew91	131	5	this	this	DT
cord-015910-d9gxew91	131	6	may	may	MD
cord-015910-d9gxew91	131	7	express	express	VB
cord-015910-d9gxew91	131	8	itself	-PRON-	PRP
cord-015910-d9gxew91	131	9	as	as	IN
cord-015910-d9gxew91	131	10	differing	differ	VBG
cord-015910-d9gxew91	131	11	degrees	degree	NNS
cord-015910-d9gxew91	131	12	of	of	IN
cord-015910-d9gxew91	131	13	morbidity	morbidity	NN
cord-015910-d9gxew91	131	14	and	and	CC
cord-015910-d9gxew91	131	15	mortality	mortality	NN
cord-015910-d9gxew91	131	16	(	(	-LRB-
cord-015910-d9gxew91	131	17	Fig	Fig	NNP
cord-015910-d9gxew91	131	18	.	.	.
cord-015910-d9gxew91	131	19	5	5	CD
cord-015910-d9gxew91	131	20	)	)	-RRB-
cord-015910-d9gxew91	131	21	.	.	.
cord-015910-d9gxew91	132	1	The	the	DT
cord-015910-d9gxew91	132	2	strength	strength	NN
cord-015910-d9gxew91	132	3	of	of	IN
cord-015910-d9gxew91	132	4	the	the	DT
cord-015910-d9gxew91	132	5	genomic	genomic	JJ
cord-015910-d9gxew91	132	6	influence	influence	NN
cord-015910-d9gxew91	132	7	on	on	IN
cord-015910-d9gxew91	132	8	the	the	DT
cord-015910-d9gxew91	132	9	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	132	10	process	process	NN
cord-015910-d9gxew91	132	11	may	may	MD
cord-015910-d9gxew91	132	12	affect	affect	VB
cord-015910-d9gxew91	132	13	the	the	DT
cord-015910-d9gxew91	132	14	chances	chance	NNS
cord-015910-d9gxew91	132	15	of	of	IN
cord-015910-d9gxew91	132	16	an	an	DT
cord-015910-d9gxew91	132	17	individual	individual	JJ
cord-015910-d9gxew91	132	18	developing	develop	VBG
cord-015910-d9gxew91	132	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	132	20	disease	disease	NN
cord-015910-d9gxew91	132	21	,	,	,
cord-015910-d9gxew91	132	22	particularly	particularly	RB
cord-015910-d9gxew91	132	23	if	if	IN
cord-015910-d9gxew91	132	24	their	-PRON-	PRP$
cord-015910-d9gxew91	132	25	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	132	26	defenses	defense	NNS
cord-015910-d9gxew91	132	27	are	be	VBP
cord-015910-d9gxew91	132	28	poor	poor	JJ
cord-015910-d9gxew91	132	29	.	.	.
cord-015910-d9gxew91	133	1	In	in	IN
cord-015910-d9gxew91	133	2	addition	addition	NN
cord-015910-d9gxew91	133	3	to	to	IN
cord-015910-d9gxew91	133	4	disease	disease	NN
cord-015910-d9gxew91	133	5	progression	progression	NN
cord-015910-d9gxew91	133	6	,	,	,
cord-015910-d9gxew91	133	7	genetic	genetic	JJ
cord-015910-d9gxew91	133	8	factors	factor	NNS
cord-015910-d9gxew91	133	9	have	have	VBP
cord-015910-d9gxew91	133	10	important	important	JJ
cord-015910-d9gxew91	133	11	effects	effect	NNS
cord-015910-d9gxew91	133	12	on	on	IN
cord-015910-d9gxew91	133	13	mortality	mortality	NN
cord-015910-d9gxew91	133	14	and	and	CC
cord-015910-d9gxew91	133	15	morbidity	morbidity	NN
cord-015910-d9gxew91	133	16	in	in	IN
cord-015910-d9gxew91	133	17	infectious	infectious	JJ
cord-015910-d9gxew91	133	18	and	and	CC
cord-015910-d9gxew91	133	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	133	20	disease	disease	NN
cord-015910-d9gxew91	133	21	and	and	CC
cord-015910-d9gxew91	133	22	following	follow	VBG
cord-015910-d9gxew91	133	23	injury	injury	NN
cord-015910-d9gxew91	133	24	(	(	-LRB-
cord-015910-d9gxew91	133	25	Paolini	Paolini	NNP
cord-015910-d9gxew91	133	26	-	-	HYPH
cord-015910-d9gxew91	133	27	Giacobino	Giacobino	NNP
cord-015910-d9gxew91	133	28	,	,	,
cord-015910-d9gxew91	133	29	Grimble	Grimble	NNP
cord-015910-d9gxew91	133	30	,	,	,
cord-015910-d9gxew91	133	31	&	&	CC
cord-015910-d9gxew91	133	32	Pichard	Pichard	NNP
cord-015910-d9gxew91	133	33	,	,	,
cord-015910-d9gxew91	133	34	2003	2003	CD
cord-015910-d9gxew91	133	35	)	)	-RRB-
cord-015910-d9gxew91	133	36	.	.	.
cord-015910-d9gxew91	134	1	There	there	EX
cord-015910-d9gxew91	134	2	are	be	VBP
cord-015910-d9gxew91	134	3	sex	sex	NN
cord-015910-d9gxew91	134	4	-	-	HYPH
cord-015910-d9gxew91	134	5	linked	link	VBN
cord-015910-d9gxew91	134	6	differences	difference	NNS
cord-015910-d9gxew91	134	7	in	in	IN
cord-015910-d9gxew91	134	8	the	the	DT
cord-015910-d9gxew91	134	9	influence	influence	NN
cord-015910-d9gxew91	134	10	of	of	IN
cord-015910-d9gxew91	134	11	genotype	genotype	NN
cord-015910-d9gxew91	134	12	on	on	IN
cord-015910-d9gxew91	134	13	the	the	DT
cord-015910-d9gxew91	134	14	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	134	15	processes	process	NNS
cord-015910-d9gxew91	134	16	.	.	.
cord-015910-d9gxew91	135	1	In	in	IN
cord-015910-d9gxew91	135	2	general	general	JJ
cord-015910-d9gxew91	135	3	,	,	,
cord-015910-d9gxew91	135	4	males	male	NNS
cord-015910-d9gxew91	135	5	are	be	VBP
cord-015910-d9gxew91	135	6	more	more	RBR
cord-015910-d9gxew91	135	7	sensitive	sensitive	JJ
cord-015910-d9gxew91	135	8	to	to	IN
cord-015910-d9gxew91	135	9	the	the	DT
cord-015910-d9gxew91	135	10	genomic	genomic	JJ
cord-015910-d9gxew91	135	11	influences	influence	NNS
cord-015910-d9gxew91	135	12	on	on	IN
cord-015910-d9gxew91	135	13	the	the	DT
cord-015910-d9gxew91	135	14	strength	strength	NN
cord-015910-d9gxew91	135	15	of	of	IN
cord-015910-d9gxew91	135	16	the	the	DT
cord-015910-d9gxew91	135	17	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	135	18	process	process	NN
cord-015910-d9gxew91	135	19	than	than	IN
cord-015910-d9gxew91	135	20	females	female	NNS
cord-015910-d9gxew91	135	21	.	.	.
cord-015910-d9gxew91	136	1	In	in	IN
cord-015910-d9gxew91	136	2	a	a	DT
cord-015910-d9gxew91	136	3	study	study	NN
cord-015910-d9gxew91	136	4	on	on	IN
cord-015910-d9gxew91	136	5	LT	LT	NNP
cord-015910-d9gxew91	136	6	-	-	:
cord-015910-d9gxew91	136	7	a	a	DT
cord-015910-d9gxew91	136	8	genotype	genotype	NN
cord-015910-d9gxew91	136	9	and	and	CC
cord-015910-d9gxew91	136	10	mortality	mortality	NN
cord-015910-d9gxew91	136	11	from	from	IN
cord-015910-d9gxew91	136	12	sepsis	sepsis	NN
cord-015910-d9gxew91	136	13	,	,	,
cord-015910-d9gxew91	136	14	it	-PRON-	PRP
cord-015910-d9gxew91	136	15	was	be	VBD
cord-015910-d9gxew91	136	16	found	find	VBN
cord-015910-d9gxew91	136	17	that	that	IN
cord-015910-d9gxew91	136	18	men	man	NNS
cord-015910-d9gxew91	136	19	possessing	possess	VBG
cord-015910-d9gxew91	136	20	a	a	DT
cord-015910-d9gxew91	136	21	TNFB22	TNFB22	NNP
cord-015910-d9gxew91	136	22	(	(	-LRB-
cord-015910-d9gxew91	136	23	LT	LT	NNP
cord-015910-d9gxew91	136	24	-	-	HYPH
cord-015910-d9gxew91	136	25	o~+	o~+	CD
cord-015910-d9gxew91	136	26	252	252	CD
cord-015910-d9gxew91	136	27	AA	AA	NNP
cord-015910-d9gxew91	136	28	)	)	-RRB-
cord-015910-d9gxew91	136	29	genotype	genotype	NN
cord-015910-d9gxew91	136	30	had	have	VBD
cord-015910-d9gxew91	136	31	a	a	DT
cord-015910-d9gxew91	136	32	mortality	mortality	NN
cord-015910-d9gxew91	136	33	of	of	IN
cord-015910-d9gxew91	136	34	72	72	CD
cord-015910-d9gxew91	136	35	%	%	NN
cord-015910-d9gxew91	136	36	compared	compare	VBN
cord-015910-d9gxew91	136	37	with	with	IN
cord-015910-d9gxew91	136	38	men	man	NNS
cord-015910-d9gxew91	136	39	who	who	WP
cord-015910-d9gxew91	136	40	were	be	VBD
cord-015910-d9gxew91	136	41	TNFB	TNFB	NNS
cord-015910-d9gxew91	136	42	11	11	CD
cord-015910-d9gxew91	137	1	(	(	-LRB-
cord-015910-d9gxew91	137	2	LT	LT	NNP
cord-015910-d9gxew91	137	3	-	-	HYPH
cord-015910-d9gxew91	137	4	o~+	o~+	CD
cord-015910-d9gxew91	137	5	252	252	CD
cord-015910-d9gxew91	137	6	GG	GG	NNP
cord-015910-d9gxew91	137	7	)	)	-RRB-
cord-015910-d9gxew91	137	8	,	,	,
cord-015910-d9gxew91	137	9	who	who	WP
cord-015910-d9gxew91	137	10	had	have	VBD
cord-015910-d9gxew91	137	11	a	a	DT
cord-015910-d9gxew91	137	12	42	42	CD
cord-015910-d9gxew91	137	13	%	%	NN
cord-015910-d9gxew91	137	14	mortality	mortality	NN
cord-015910-d9gxew91	137	15	rate	rate	NN
cord-015910-d9gxew91	137	16	.	.	.
cord-015910-d9gxew91	138	1	In	in	IN
cord-015910-d9gxew91	138	2	female	female	JJ
cord-015910-d9gxew91	138	3	patients	patient	NNS
cord-015910-d9gxew91	138	4	the	the	DT
cord-015910-d9gxew91	138	5	mortalities	mortality	NNS
cord-015910-d9gxew91	138	6	for	for	IN
cord-015910-d9gxew91	138	7	the	the	DT
cord-015910-d9gxew91	138	8	two	two	CD
cord-015910-d9gxew91	138	9	genotypes	genotype	NNS
cord-015910-d9gxew91	138	10	were	be	VBD
cord-015910-d9gxew91	138	11	53	53	CD
cord-015910-d9gxew91	138	12	%	%	NN
cord-015910-d9gxew91	138	13	and	and	CC
cord-015910-d9gxew91	138	14	33	33	CD
cord-015910-d9gxew91	138	15	%	%	NN
cord-015910-d9gxew91	138	16	,	,	,
cord-015910-d9gxew91	138	17	respectively	respectively	RB
cord-015910-d9gxew91	138	18	(	(	-LRB-
cord-015910-d9gxew91	138	19	Schroder	Schroder	NNP
cord-015910-d9gxew91	138	20	,	,	,
cord-015910-d9gxew91	138	21	Kahlke	Kahlke	NNP
cord-015910-d9gxew91	138	22	,	,	,
cord-015910-d9gxew91	138	23	Book	Book	NNP
cord-015910-d9gxew91	138	24	,	,	,
cord-015910-d9gxew91	138	25	&	&	CC
cord-015910-d9gxew91	138	26	Stuber	Stuber	NNP
cord-015910-d9gxew91	138	27	,	,	,
cord-015910-d9gxew91	138	28	2000	2000	CD
cord-015910-d9gxew91	138	29	)	)	-RRB-
cord-015910-d9gxew91	138	30	.	.	.
cord-015910-d9gxew91	139	1	In	in	IN
cord-015910-d9gxew91	139	2	a	a	DT
cord-015910-d9gxew91	139	3	study	study	NN
cord-015910-d9gxew91	139	4	on	on	IN
cord-015910-d9gxew91	139	5	patients	patient	NNS
cord-015910-d9gxew91	139	6	undergoing	undergo	VBG
cord-015910-d9gxew91	139	7	surgery	surgery	NN
cord-015910-d9gxew91	139	8	for	for	IN
cord-015910-d9gxew91	139	9	gastrointestinal	gastrointestinal	JJ
cord-015910-d9gxew91	139	10	cancer	cancer	NN
cord-015910-d9gxew91	139	11	,	,	,
cord-015910-d9gxew91	139	12	it	-PRON-	PRP
cord-015910-d9gxew91	139	13	was	be	VBD
cord-015910-d9gxew91	139	14	found	find	VBN
cord-015910-d9gxew91	139	15	that	that	IN
cord-015910-d9gxew91	139	16	postoperative	postoperative	JJ
cord-015910-d9gxew91	139	17	C	c	NN
cord-015910-d9gxew91	139	18	-	-	HYPH
cord-015910-d9gxew91	139	19	reactive	reactive	JJ
cord-015910-d9gxew91	139	20	protein	protein	NN
cord-015910-d9gxew91	139	21	(	(	-LRB-
cord-015910-d9gxew91	139	22	CRP	CRP	NNP
cord-015910-d9gxew91	139	23	)	)	-RRB-
cord-015910-d9gxew91	139	24	and	and	CC
cord-015910-d9gxew91	139	25	IL-6	IL-6	NNP
cord-015910-d9gxew91	139	26	concentrations	concentration	NNS
cord-015910-d9gxew91	139	27	were	be	VBD
cord-015910-d9gxew91	139	28	higher	high	JJR
cord-015910-d9gxew91	139	29	in	in	IN
cord-015910-d9gxew91	139	30	men	man	NNS
cord-015910-d9gxew91	139	31	than	than	IN
cord-015910-d9gxew91	139	32	in	in	IN
cord-015910-d9gxew91	139	33	women	woman	NNS
cord-015910-d9gxew91	139	34	.	.	.
cord-015910-d9gxew91	140	1	Multivariate	multivariate	JJ
cord-015910-d9gxew91	140	2	analysis	analysis	NN
cord-015910-d9gxew91	140	3	showed	show	VBD
cord-015910-d9gxew91	140	4	that	that	IN
cord-015910-d9gxew91	140	5	males	male	NNS
cord-015910-d9gxew91	140	6	possessing	possess	VBG
cord-015910-d9gxew91	140	7	the	the	DT
cord-015910-d9gxew91	140	8	TNF2	TNF2	NNP
cord-015910-d9gxew91	140	9	(	(	-LRB-
cord-015910-d9gxew91	140	10	TNF	TNF	NNP
cord-015910-d9gxew91	140	11	-	-	HYPH
cord-015910-d9gxew91	140	12	o~-308	o~-308	NNP
cord-015910-d9gxew91	140	13	A	A	NNP
cord-015910-d9gxew91	140	14	)	)	-RRB-
cord-015910-d9gxew91	140	15	allele	allele	NN
cord-015910-d9gxew91	140	16	had	have	VBD
cord-015910-d9gxew91	140	17	greater	great	JJR
cord-015910-d9gxew91	140	18	responses	response	NNS
cord-015910-d9gxew91	140	19	than	than	IN
cord-015910-d9gxew91	140	20	men	man	NNS
cord-015910-d9gxew91	140	21	without	without	IN
cord-015910-d9gxew91	140	22	it	-PRON-	PRP
cord-015910-d9gxew91	140	23	.	.	.
cord-015910-d9gxew91	141	1	The	the	DT
cord-015910-d9gxew91	141	2	genomic	genomic	JJ
cord-015910-d9gxew91	141	3	influence	influence	NN
cord-015910-d9gxew91	141	4	was	be	VBD
cord-015910-d9gxew91	141	5	not	not	RB
cord-015910-d9gxew91	141	6	seen	see	VBN
cord-015910-d9gxew91	141	7	in	in	IN
cord-015910-d9gxew91	141	8	females	female	NNS
cord-015910-d9gxew91	141	9	(	(	-LRB-
cord-015910-d9gxew91	141	10	Table	table	NN
cord-015910-d9gxew91	141	11	2	2	CD
cord-015910-d9gxew91	141	12	)	)	-RRB-
cord-015910-d9gxew91	141	13	(	(	-LRB-
cord-015910-d9gxew91	141	14	Grimble	Grimble	NNP
cord-015910-d9gxew91	141	15	,	,	,
cord-015910-d9gxew91	141	16	Thorell	Thorell	NNP
cord-015910-d9gxew91	141	17	,	,	,
cord-015910-d9gxew91	141	18	et	et	NNP
cord-015910-d9gxew91	141	19	al	al	NNP
cord-015910-d9gxew91	141	20	.	.	NNP
cord-015910-d9gxew91	141	21	,	,	,
cord-015910-d9gxew91	141	22	2003	2003	CD
cord-015910-d9gxew91	141	23	)	)	-RRB-
cord-015910-d9gxew91	141	24	.	.	.
cord-015910-d9gxew91	142	1	Furthermore	furthermore	RB
cord-015910-d9gxew91	142	2	,	,	,
cord-015910-d9gxew91	142	3	possession	possession	NN
cord-015910-d9gxew91	142	4	of	of	IN
cord-015910-d9gxew91	142	5	the	the	DT
cord-015910-d9gxew91	142	6	IL-1	IL-1	NNP
cord-015910-d9gxew91	142	7	-	-	HYPH
cord-015910-d9gxew91	142	8	511	511	CD
cord-015910-d9gxew91	142	9	T	T	NNP
cord-015910-d9gxew91	142	10	allele	allele	NN
cord-015910-d9gxew91	142	11	was	be	VBD
cord-015910-d9gxew91	142	12	associated	associate	VBN
cord-015910-d9gxew91	142	13	with	with	IN
cord-015910-d9gxew91	142	14	a	a	DT
cord-015910-d9gxew91	142	15	48	48	CD
cord-015910-d9gxew91	142	16	%	%	NN
cord-015910-d9gxew91	142	17	greater	great	JJR
cord-015910-d9gxew91	142	18	length	length	NN
cord-015910-d9gxew91	142	19	of	of	IN
cord-015910-d9gxew91	142	20	stay	stay	NN
cord-015910-d9gxew91	142	21	in	in	IN
cord-015910-d9gxew91	142	22	hospital	hospital	NN
cord-015910-d9gxew91	142	23	in	in	IN
cord-015910-d9gxew91	142	24	old	old	JJ
cord-015910-d9gxew91	142	25	men	man	NNS
cord-015910-d9gxew91	142	26	admitted	admit	VBD
cord-015910-d9gxew91	142	27	for	for	IN
cord-015910-d9gxew91	142	28	geriatric	geriatric	JJ
cord-015910-d9gxew91	142	29	care	care	NN
cord-015910-d9gxew91	142	30	(	(	-LRB-
cord-015910-d9gxew91	142	31	Table	table	NN
cord-015910-d9gxew91	142	32	3	3	CD
cord-015910-d9gxew91	142	33	)	)	-RRB-
cord-015910-d9gxew91	142	34	(	(	-LRB-
cord-015910-d9gxew91	142	35	Grimble	Grimble	NNP
cord-015910-d9gxew91	142	36	,	,	,
cord-015910-d9gxew91	142	37	Anderson	Anderson	NNP
cord-015910-d9gxew91	142	38	,	,	,
cord-015910-d9gxew91	142	39	et	et	NNP
cord-015910-d9gxew91	142	40	al	al	NNP
cord-015910-d9gxew91	142	41	.	.	NNP
cord-015910-d9gxew91	142	42	,	,	,
cord-015910-d9gxew91	142	43	2003	2003	CD
cord-015910-d9gxew91	142	44	)	)	-RRB-
cord-015910-d9gxew91	142	45	.	.	.
cord-015910-d9gxew91	143	1	Women	woman	NNS
cord-015910-d9gxew91	143	2	were	be	VBD
cord-015910-d9gxew91	143	3	unaffected	unaffected	JJ
cord-015910-d9gxew91	143	4	by	by	IN
cord-015910-d9gxew91	143	5	these	these	DT
cord-015910-d9gxew91	143	6	genetic	genetic	JJ
cord-015910-d9gxew91	143	7	influences	influence	NNS
cord-015910-d9gxew91	143	8	.	.	.
cord-015910-d9gxew91	144	1	Paradoxically	paradoxically	RB
cord-015910-d9gxew91	144	2	,	,	,
cord-015910-d9gxew91	144	3	with	with	IN
cord-015910-d9gxew91	144	4	improvements	improvement	NNS
cord-015910-d9gxew91	144	5	in	in	IN
cord-015910-d9gxew91	144	6	hygiene	hygiene	NN
cord-015910-d9gxew91	144	7	and	and	CC
cord-015910-d9gxew91	144	8	vaccination	vaccination	NN
cord-015910-d9gxew91	144	9	programs	program	NNS
cord-015910-d9gxew91	144	10	against	against	IN
cord-015910-d9gxew91	144	11	infectious	infectious	JJ
cord-015910-d9gxew91	144	12	diseases	disease	NNS
cord-015910-d9gxew91	144	13	,	,	,
cord-015910-d9gxew91	144	14	two	two	CD
cord-015910-d9gxew91	144	15	major	major	JJ
cord-015910-d9gxew91	144	16	changes	change	NNS
cord-015910-d9gxew91	144	17	in	in	IN
cord-015910-d9gxew91	144	18	public	public	JJ
cord-015910-d9gxew91	144	19	health	health	NN
cord-015910-d9gxew91	144	20	and	and	CC
cord-015910-d9gxew91	144	21	population	population	NN
cord-015910-d9gxew91	144	22	characteristics	characteristic	NNS
cord-015910-d9gxew91	144	23	have	have	VBP
cord-015910-d9gxew91	144	24	led	lead	VBN
cord-015910-d9gxew91	144	25	to	to	IN
cord-015910-d9gxew91	144	26	a	a	DT
cord-015910-d9gxew91	144	27	general	general	JJ
cord-015910-d9gxew91	144	28	increase	increase	NN
cord-015910-d9gxew91	144	29	in	in	IN
cord-015910-d9gxew91	144	30	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	144	31	stress	stress	NN
cord-015910-d9gxew91	144	32	in	in	IN
cord-015910-d9gxew91	144	33	populations	population	NNS
cord-015910-d9gxew91	144	34	of	of	IN
cord-015910-d9gxew91	144	35	industrialized	industrialized	JJ
cord-015910-d9gxew91	144	36	countries	country	NNS
cord-015910-d9gxew91	144	37	in	in	IN
cord-015910-d9gxew91	144	38	the	the	DT
cord-015910-d9gxew91	144	39	last	last	JJ
cord-015910-d9gxew91	144	40	half	half	JJ
cord-015910-d9gxew91	144	41	century	century	NN
cord-015910-d9gxew91	144	42	.	.	.
cord-015910-d9gxew91	145	1	These	these	DT
cord-015910-d9gxew91	145	2	are	be	VBP
cord-015910-d9gxew91	145	3	,	,	,
cord-015910-d9gxew91	145	4	respectively	respectively	RB
cord-015910-d9gxew91	145	5	,	,	,
cord-015910-d9gxew91	145	6	an	an	DT
cord-015910-d9gxew91	145	7	increase	increase	NN
cord-015910-d9gxew91	145	8	in	in	IN
cord-015910-d9gxew91	145	9	the	the	DT
cord-015910-d9gxew91	145	10	number	number	NN
cord-015910-d9gxew91	145	11	of	of	IN
cord-015910-d9gxew91	145	12	overweight	overweight	JJ
cord-015910-d9gxew91	145	13	and	and	CC
cord-015910-d9gxew91	145	14	obese	obese	JJ
cord-015910-d9gxew91	145	15	subjects	subject	NNS
cord-015910-d9gxew91	145	16	and	and	CC
cord-015910-d9gxew91	145	17	an	an	DT
cord-015910-d9gxew91	145	18	increase	increase	NN
cord-015910-d9gxew91	145	19	in	in	IN
cord-015910-d9gxew91	145	20	longevity	longevity	NN
cord-015910-d9gxew91	145	21	.	.	.
cord-015910-d9gxew91	146	1	We	-PRON-	PRP
cord-015910-d9gxew91	146	2	will	will	MD
cord-015910-d9gxew91	146	3	now	now	RB
cord-015910-d9gxew91	146	4	examine	examine	VB
cord-015910-d9gxew91	146	5	the	the	DT
cord-015910-d9gxew91	146	6	mechanisms	mechanism	NNS
cord-015910-d9gxew91	146	7	underlying	underlie	VBG
cord-015910-d9gxew91	146	8	this	this	DT
cord-015910-d9gxew91	146	9	phenomenon	phenomenon	NN
cord-015910-d9gxew91	146	10	.	.	.
cord-015910-d9gxew91	147	1	It	-PRON-	PRP
cord-015910-d9gxew91	147	2	has	have	VBZ
cord-015910-d9gxew91	147	3	been	be	VBN
cord-015910-d9gxew91	147	4	recognized	recognize	VBN
cord-015910-d9gxew91	147	5	for	for	IN
cord-015910-d9gxew91	147	6	many	many	JJ
cord-015910-d9gxew91	147	7	years	year	NNS
cord-015910-d9gxew91	147	8	that	that	IN
cord-015910-d9gxew91	147	9	there	there	EX
cord-015910-d9gxew91	147	10	is	be	VBZ
cord-015910-d9gxew91	147	11	a	a	DT
cord-015910-d9gxew91	147	12	strong	strong	JJ
cord-015910-d9gxew91	147	13	link	link	NN
cord-015910-d9gxew91	147	14	between	between	IN
cord-015910-d9gxew91	147	15	the	the	DT
cord-015910-d9gxew91	147	16	"	"	``
cord-015910-d9gxew91	147	17	diseases	disease	NNS
cord-015910-d9gxew91	147	18	of	of	IN
cord-015910-d9gxew91	147	19	affluence"--obesity	affluence"--obesity	NN
cord-015910-d9gxew91	147	20	,	,	,
cord-015910-d9gxew91	147	21	insulin	insulin	NN
cord-015910-d9gxew91	147	22	sensitivity	sensitivity	NN
cord-015910-d9gxew91	147	23	,	,	,
cord-015910-d9gxew91	147	24	and	and	CC
cord-015910-d9gxew91	147	25	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	147	26	.	.	.
cord-015910-d9gxew91	148	1	However	however	RB
cord-015910-d9gxew91	148	2	,	,	,
cord-015910-d9gxew91	148	3	it	-PRON-	PRP
cord-015910-d9gxew91	148	4	is	be	VBZ
cord-015910-d9gxew91	148	5	only	only	RB
cord-015910-d9gxew91	148	6	quite	quite	RB
cord-015910-d9gxew91	148	7	recently	recently	RB
cord-015910-d9gxew91	148	8	that	that	IN
cord-015910-d9gxew91	148	9	the	the	DT
cord-015910-d9gxew91	148	10	realization	realization	NN
cord-015910-d9gxew91	148	11	came	come	VBD
cord-015910-d9gxew91	148	12	that	that	IN
cord-015910-d9gxew91	148	13	inflammation	inflammation	NN
cord-015910-d9gxew91	148	14	provided	provide	VBD
cord-015910-d9gxew91	148	15	a	a	DT
cord-015910-d9gxew91	148	16	link	link	NN
cord-015910-d9gxew91	148	17	between	between	IN
cord-015910-d9gxew91	148	18	the	the	DT
cord-015910-d9gxew91	148	19	three	three	CD
cord-015910-d9gxew91	148	20	(	(	-LRB-
cord-015910-d9gxew91	148	21	5	5	CD
cord-015910-d9gxew91	148	22	)	)	-RRB-
cord-015910-d9gxew91	148	23	TNF	TNF	NNP
cord-015910-d9gxew91	148	24	,	,	,
cord-015910-d9gxew91	148	25	tumor	tumor	NN
cord-015910-d9gxew91	148	26	necrosis	necrosis	NN
cord-015910-d9gxew91	148	27	factor	factor	NN
cord-015910-d9gxew91	148	28	;	;	:
cord-015910-d9gxew91	148	29	IL	IL	NNP
cord-015910-d9gxew91	148	30	,	,	,
cord-015910-d9gxew91	148	31	interleukin	interleukin	NN
cord-015910-d9gxew91	148	32	;	;	:
cord-015910-d9gxew91	148	33	CRP	CRP	NNP
cord-015910-d9gxew91	148	34	,	,	,
cord-015910-d9gxew91	148	35	C	C	NNP
cord-015910-d9gxew91	148	36	-	-	HYPH
cord-015910-d9gxew91	148	37	reactive	reactive	JJ
cord-015910-d9gxew91	148	38	protein	protein	NN
cord-015910-d9gxew91	148	39	.	.	.
cord-015910-d9gxew91	149	1	a2	a2	NNP
cord-015910-d9gxew91	149	2	d	d	NNP
cord-015910-d9gxew91	149	3	postoperatively	postoperatively	NNP
cord-015910-d9gxew91	149	4	.	.	.
cord-015910-d9gxew91	150	1	bl	bl	NNP
cord-015910-d9gxew91	150	2	d	d	NNP
cord-015910-d9gxew91	150	3	postoperatively	postoperatively	NNP
cord-015910-d9gxew91	150	4	.	.	.
cord-015910-d9gxew91	151	1	*	*	NFP
cord-015910-d9gxew91	152	1	Significantly	significantly	RB
cord-015910-d9gxew91	152	2	different	different	JJ
cord-015910-d9gxew91	152	3	from	from	IN
cord-015910-d9gxew91	152	4	females	female	NNS
cord-015910-d9gxew91	152	5	with	with	IN
cord-015910-d9gxew91	152	6	same	same	JJ
cord-015910-d9gxew91	152	7	genotype	genotype	NN
cord-015910-d9gxew91	152	8	by	by	IN
cord-015910-d9gxew91	152	9	multivariate	multivariate	JJ
cord-015910-d9gxew91	152	10	analysis	analysis	NN
cord-015910-d9gxew91	152	11	allowing	allow	VBG
cord-015910-d9gxew91	152	12	for	for	IN
cord-015910-d9gxew91	152	13	longer	long	JJR
cord-015910-d9gxew91	152	14	operation	operation	NN
cord-015910-d9gxew91	152	15	time	time	NN
cord-015910-d9gxew91	152	16	and	and	CC
cord-015910-d9gxew91	152	17	greater	great	JJR
cord-015910-d9gxew91	152	18	blood	blood	NN
cord-015910-d9gxew91	152	19	loss	loss	NN
cord-015910-d9gxew91	152	20	;	;	:
cord-015910-d9gxew91	152	21	p	p	NN
cord-015910-d9gxew91	152	22	=	=	SYM
cord-015910-d9gxew91	152	23	0.013	0.013	CD
cord-015910-d9gxew91	152	24	andp	andp	NN
cord-015910-d9gxew91	152	25	=	=	SYM
cord-015910-d9gxew91	152	26	0.027	0.027	CD
cord-015910-d9gxew91	152	27	for	for	IN
cord-015910-d9gxew91	152	28	CRP	CRP	NNP
cord-015910-d9gxew91	152	29	and	and	CC
cord-015910-d9gxew91	152	30	IL-6	IL-6	NNP
cord-015910-d9gxew91	152	31	,	,	,
cord-015910-d9gxew91	152	32	respectively	respectively	RB
cord-015910-d9gxew91	152	33	.	.	.
cord-015910-d9gxew91	153	1	Means	mean	NNS
cord-015910-d9gxew91	153	2	+	+	CC
cord-015910-d9gxew91	153	3	SD	sd	NN
cord-015910-d9gxew91	153	4	,	,	,
cord-015910-d9gxew91	153	5	values	value	NNS
cord-015910-d9gxew91	153	6	in	in	IN
cord-015910-d9gxew91	153	7	parentheses	parenthesis	NNS
cord-015910-d9gxew91	153	8	are	be	VBP
cord-015910-d9gxew91	153	9	the	the	DT
cord-015910-d9gxew91	153	10	number	number	NN
cord-015910-d9gxew91	153	11	of	of	IN
cord-015910-d9gxew91	153	12	patients	patient	NNS
cord-015910-d9gxew91	153	13	.	.	.
cord-015910-d9gxew91	154	1	(	(	-LRB-
cord-015910-d9gxew91	154	2	28	28	CD
cord-015910-d9gxew91	154	3	)	)	-RRB-
cord-015910-d9gxew91	154	4	27	27	CD
cord-015910-d9gxew91	154	5	+	+	SYM
cord-015910-d9gxew91	154	6	13	13	CD
cord-015910-d9gxew91	154	7	(	(	-LRB-
cord-015910-d9gxew91	154	8	9	9	CD
cord-015910-d9gxew91	154	9	)	)	-RRB-
cord-015910-d9gxew91	154	10	19	19	CD
cord-015910-d9gxew91	154	11	+15	+15	NNS
cord-015910-d9gxew91	154	12	(	(	-LRB-
cord-015910-d9gxew91	154	13	26	26	CD
cord-015910-d9gxew91	154	14	)	)	-RRB-
cord-015910-d9gxew91	154	15	14	14	CD
cord-015910-d9gxew91	154	16	+	+	SYM
cord-015910-d9gxew91	154	17	13(16	13(16	CD
cord-015910-d9gxew91	154	18	)	)	-RRB-
cord-015910-d9gxew91	155	1	*	*	NFP
cord-015910-d9gxew91	155	2	25	25	CD
cord-015910-d9gxew91	155	3	+14	+14	CD
cord-015910-d9gxew91	155	4	(	(	-LRB-
cord-015910-d9gxew91	155	5	28	28	CD
cord-015910-d9gxew91	155	6	)	)	-RRB-
cord-015910-d9gxew91	155	7	TNF	TNF	NNP
cord-015910-d9gxew91	155	8	,	,	,
cord-015910-d9gxew91	155	9	tumor	tumor	NN
cord-015910-d9gxew91	155	10	necrosis	necrosis	NN
cord-015910-d9gxew91	155	11	factor	factor	NN
cord-015910-d9gxew91	155	12	;	;	:
cord-015910-d9gxew91	155	13	IL	IL	NNP
cord-015910-d9gxew91	155	14	,	,	,
cord-015910-d9gxew91	155	15	interleukin	interleukin	NN
cord-015910-d9gxew91	155	16	;	;	:
cord-015910-d9gxew91	155	17	C	c	NN
cord-015910-d9gxew91	155	18	,	,	,
cord-015910-d9gxew91	155	19	cytosine	cytosine	NN
cord-015910-d9gxew91	155	20	;	;	:
cord-015910-d9gxew91	155	21	T	T	NNP
cord-015910-d9gxew91	155	22	,	,	,
cord-015910-d9gxew91	155	23	thymidine	thymidine	NN
cord-015910-d9gxew91	155	24	;	;	:
cord-015910-d9gxew91	155	25	A	a	NN
cord-015910-d9gxew91	155	26	,	,	,
cord-015910-d9gxew91	155	27	adenine	adenine	NN
cord-015910-d9gxew91	155	28	;	;	:
cord-015910-d9gxew91	155	29	G	g	NN
cord-015910-d9gxew91	155	30	,	,	,
cord-015910-d9gxew91	155	31	guanine	guanine	NN
cord-015910-d9gxew91	155	32	.	.	.
cord-015910-d9gxew91	156	1	aThe	athe	JJ
cord-015910-d9gxew91	156	2	location	location	NN
cord-015910-d9gxew91	156	3	of	of	IN
cord-015910-d9gxew91	156	4	the	the	DT
cord-015910-d9gxew91	156	5	polymorphism	polymorphism	NN
cord-015910-d9gxew91	156	6	is	be	VBZ
cord-015910-d9gxew91	156	7	indicated	indicate	VBN
cord-015910-d9gxew91	156	8	by	by	IN
cord-015910-d9gxew91	156	9	the	the	DT
cord-015910-d9gxew91	156	10	nucleotide	nucleotide	JJ
cord-015910-d9gxew91	156	11	position	position	NN
cord-015910-d9gxew91	156	12	in	in	IN
cord-015910-d9gxew91	156	13	the	the	DT
cord-015910-d9gxew91	156	14	IL-1	IL-1	NNP
cord-015910-d9gxew91	156	15	~	~	NFP
cord-015910-d9gxew91	156	16	and	and	CC
cord-015910-d9gxew91	156	17	LT	LT	NNP
cord-015910-d9gxew91	156	18	-	-	HYPH
cord-015910-d9gxew91	156	19	t~	t~	NNP
cord-015910-d9gxew91	156	20	genes	gene	NNS
cord-015910-d9gxew91	156	21	,	,	,
cord-015910-d9gxew91	156	22	TNFB	TNFB	NNS
cord-015910-d9gxew91	156	23	11	11	CD
cord-015910-d9gxew91	156	24	(	(	-LRB-
cord-015910-d9gxew91	156	25	GG	GG	NNP
cord-015910-d9gxew91	156	26	)	)	-RRB-
cord-015910-d9gxew91	156	27	,	,	,
cord-015910-d9gxew91	156	28	TNFB	TNFB	NNP
cord-015910-d9gxew91	156	29	12(AG	12(ag	CD
cord-015910-d9gxew91	156	30	)	)	-RRB-
cord-015910-d9gxew91	156	31	,	,	,
cord-015910-d9gxew91	156	32	TNFB22(AA	TNFB22(AA	NNP
cord-015910-d9gxew91	156	33	)	)	-RRB-
cord-015910-d9gxew91	156	34	.	.	.
cord-015910-d9gxew91	157	1	*	*	NFP
cord-015910-d9gxew91	157	2	Significantly	significantly	RB
cord-015910-d9gxew91	157	3	different	different	JJ
cord-015910-d9gxew91	157	4	from	from	IN
cord-015910-d9gxew91	157	5	value	value	NN
cord-015910-d9gxew91	157	6	for	for	IN
cord-015910-d9gxew91	157	7	same	same	JJ
cord-015910-d9gxew91	157	8	sex	sex	NN
cord-015910-d9gxew91	157	9	possessing	possess	VBG
cord-015910-d9gxew91	157	10	the	the	DT
cord-015910-d9gxew91	157	11	other	other	JJ
cord-015910-d9gxew91	157	12	genotype	genotype	NN
cord-015910-d9gxew91	157	13	;	;	:
cord-015910-d9gxew91	157	14	p	p	NN
cord-015910-d9gxew91	157	15	<	<	XX
cord-015910-d9gxew91	157	16	0.05	0.05	CD
cord-015910-d9gxew91	157	17	using	use	VBG
cord-015910-d9gxew91	157	18	Mann	Mann	NNP
cord-015910-d9gxew91	157	19	-	-	HYPH
cord-015910-d9gxew91	157	20	Whitney	Whitney	NNP
cord-015910-d9gxew91	157	21	Test	Test	NNP
cord-015910-d9gxew91	157	22	.	.	.
cord-015910-d9gxew91	158	1	Means	mean	NNS
cord-015910-d9gxew91	158	2	+	+	CC
cord-015910-d9gxew91	158	3	SD	sd	NN
cord-015910-d9gxew91	158	4	,	,	,
cord-015910-d9gxew91	158	5	values	value	NNS
cord-015910-d9gxew91	158	6	in	in	IN
cord-015910-d9gxew91	158	7	parentheses	parenthesis	NNS
cord-015910-d9gxew91	158	8	are	be	VBP
cord-015910-d9gxew91	158	9	the	the	DT
cord-015910-d9gxew91	158	10	number	number	NN
cord-015910-d9gxew91	158	11	of	of	IN
cord-015910-d9gxew91	158	12	patients	patient	NNS
cord-015910-d9gxew91	158	13	.	.	.
cord-015910-d9gxew91	159	1	biological	biological	JJ
cord-015910-d9gxew91	159	2	phenomena	phenomenon	NNS
cord-015910-d9gxew91	159	3	(	(	-LRB-
cord-015910-d9gxew91	159	4	Fig	fig	NN
cord-015910-d9gxew91	159	5	.	.	.
cord-015910-d9gxew91	159	6	3	3	CD
cord-015910-d9gxew91	159	7	)	)	-RRB-
cord-015910-d9gxew91	159	8	.	.	.
cord-015910-d9gxew91	160	1	Many	many	JJ
cord-015910-d9gxew91	160	2	studies	study	NNS
cord-015910-d9gxew91	160	3	have	have	VBP
cord-015910-d9gxew91	160	4	shown	show	VBN
cord-015910-d9gxew91	160	5	a	a	DT
cord-015910-d9gxew91	160	6	clear	clear	JJ
cord-015910-d9gxew91	160	7	link	link	NN
cord-015910-d9gxew91	160	8	between	between	IN
cord-015910-d9gxew91	160	9	obesity	obesity	NN
cord-015910-d9gxew91	160	10	,	,	,
cord-015910-d9gxew91	160	11	oxidant	oxidant	JJ
cord-015910-d9gxew91	160	12	stress	stress	NN
cord-015910-d9gxew91	160	13	,	,	,
cord-015910-d9gxew91	160	14	and	and	CC
cord-015910-d9gxew91	160	15	inflammation	inflammation	NN
cord-015910-d9gxew91	160	16	(	(	-LRB-
cord-015910-d9gxew91	160	17	Grimble	Grimble	NNP
cord-015910-d9gxew91	160	18	2002	2002	CD
cord-015910-d9gxew91	160	19	)	)	-RRB-
cord-015910-d9gxew91	160	20	.	.	.
cord-015910-d9gxew91	161	1	The	the	DT
cord-015910-d9gxew91	161	2	link	link	NN
cord-015910-d9gxew91	161	3	may	may	MD
cord-015910-d9gxew91	161	4	lie	lie	VB
cord-015910-d9gxew91	161	5	in	in	IN
cord-015910-d9gxew91	161	6	the	the	DT
cord-015910-d9gxew91	161	7	ability	ability	NN
cord-015910-d9gxew91	161	8	of	of	IN
cord-015910-d9gxew91	161	9	adipose	adipose	JJ
cord-015910-d9gxew91	161	10	tissue	tissue	NN
cord-015910-d9gxew91	161	11	to	to	TO
cord-015910-d9gxew91	161	12	produce	produce	VB
cord-015910-d9gxew91	161	13	pro	pro	JJ
cord-015910-d9gxew91	161	14	-	-	JJ
cord-015910-d9gxew91	161	15	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	161	16	cytokines	cytokine	NNS
cord-015910-d9gxew91	161	17	,	,	,
cord-015910-d9gxew91	161	18	particularly	particularly	RB
cord-015910-d9gxew91	161	19	TNF	TNF	NNP
cord-015910-d9gxew91	161	20	-	-	HYPH
cord-015910-d9gxew91	161	21	t~.	t~.	NNP
cord-015910-d9gxew91	162	1	There	there	EX
cord-015910-d9gxew91	162	2	is	be	VBZ
cord-015910-d9gxew91	162	3	a	a	DT
cord-015910-d9gxew91	162	4	positive	positive	JJ
cord-015910-d9gxew91	162	5	relationship	relationship	NN
cord-015910-d9gxew91	162	6	between	between	IN
cord-015910-d9gxew91	162	7	adiposity	adiposity	NN
cord-015910-d9gxew91	162	8	and	and	CC
cord-015910-d9gxew91	162	9	TNF	TNF	NNP
cord-015910-d9gxew91	162	10	production	production	NN
cord-015910-d9gxew91	162	11	.	.	.
cord-015910-d9gxew91	163	1	A	a	DT
cord-015910-d9gxew91	163	2	positive	positive	JJ
cord-015910-d9gxew91	163	3	correlation	correlation	NN
cord-015910-d9gxew91	163	4	,	,	,
cord-015910-d9gxew91	163	5	I	-PRON-	PRP
cord-015910-d9gxew91	163	6	,	,	,
cord-015910-d9gxew91	163	7	Plasma	plasma	NN
cord-015910-d9gxew91	163	8	triglyceride	triglyceride	NN
cord-015910-d9gxew91	163	9	concentrations	concentration	NNS
cord-015910-d9gxew91	163	10	Fig	Fig	NNP
cord-015910-d9gxew91	163	11	.	.	NNP
cord-015910-d9gxew91	163	12	6	6	CD
cord-015910-d9gxew91	163	13	.	.	.
cord-015910-d9gxew91	164	1	Interaction	interaction	NN
cord-015910-d9gxew91	164	2	between	between	IN
cord-015910-d9gxew91	164	3	leptin	leptin	NN
cord-015910-d9gxew91	164	4	and	and	CC
cord-015910-d9gxew91	164	5	tumor	tumor	NN
cord-015910-d9gxew91	164	6	necrosis	necrosis	NN
cord-015910-d9gxew91	164	7	factor	factor	NN
cord-015910-d9gxew91	164	8	(	(	-LRB-
cord-015910-d9gxew91	164	9	TNF	TNF	NNP
cord-015910-d9gxew91	164	10	)	)	-RRB-
cord-015910-d9gxew91	164	11	with	with	IN
cord-015910-d9gxew91	164	12	adipose	adipose	JJ
cord-015910-d9gxew91	164	13	tissue	tissue	NN
cord-015910-d9gxew91	164	14	mass	mass	NN
cord-015910-d9gxew91	164	15	,	,	,
cord-015910-d9gxew91	164	16	lipid	lipid	NN
cord-015910-d9gxew91	164	17	metabolism	metabolism	NN
cord-015910-d9gxew91	164	18	,	,	,
cord-015910-d9gxew91	164	19	and	and	CC
cord-015910-d9gxew91	164	20	inflammation	inflammation	NN
cord-015910-d9gxew91	164	21	.	.	.
cord-015910-d9gxew91	165	1	TNF	TNF	NNP
cord-015910-d9gxew91	165	2	and	and	CC
cord-015910-d9gxew91	165	3	leptin	leptin	NN
cord-015910-d9gxew91	165	4	stimulate	stimulate	VBP
cord-015910-d9gxew91	165	5	the	the	DT
cord-015910-d9gxew91	165	6	immune	immune	JJ
cord-015910-d9gxew91	165	7	system	system	NN
cord-015910-d9gxew91	165	8	and	and	CC
cord-015910-d9gxew91	165	9	adipose	adipose	JJ
cord-015910-d9gxew91	165	10	tissue	tissue	NN
cord-015910-d9gxew91	165	11	,	,	,
cord-015910-d9gxew91	165	12	respectively	respectively	RB
cord-015910-d9gxew91	165	13	.	.	.
cord-015910-d9gxew91	166	1	Both	both	DT
cord-015910-d9gxew91	166	2	also	also	RB
cord-015910-d9gxew91	166	3	act	act	VB
cord-015910-d9gxew91	166	4	on	on	IN
cord-015910-d9gxew91	166	5	lipid	lipid	NN
cord-015910-d9gxew91	166	6	metabolism	metabolism	NN
cord-015910-d9gxew91	166	7	and	and	CC
cord-015910-d9gxew91	166	8	plasma	plasma	NN
cord-015910-d9gxew91	166	9	triglyceride	triglyceride	NN
cord-015910-d9gxew91	166	10	concentrations	concentration	NNS
cord-015910-d9gxew91	166	11	.	.	.
cord-015910-d9gxew91	167	1	between	between	IN
cord-015910-d9gxew91	167	2	serum	serum	NN
cord-015910-d9gxew91	167	3	TNF-~	tnf-~	CD
cord-015910-d9gxew91	167	4	production	production	NN
cord-015910-d9gxew91	167	5	and	and	CC
cord-015910-d9gxew91	167	6	body	body	NN
cord-015910-d9gxew91	167	7	mass	mass	NN
cord-015910-d9gxew91	167	8	index	index	NN
cord-015910-d9gxew91	167	9	(	(	-LRB-
cord-015910-d9gxew91	167	10	BMI	BMI	NNP
cord-015910-d9gxew91	167	11	)	)	-RRB-
cord-015910-d9gxew91	167	12	has	have	VBZ
cord-015910-d9gxew91	167	13	been	be	VBN
cord-015910-d9gxew91	167	14	noted	note	VBN
cord-015910-d9gxew91	167	15	in	in	IN
cord-015910-d9gxew91	167	16	NIDDM	NIDDM	NNP
cord-015910-d9gxew91	167	17	patients	patient	NNS
cord-015910-d9gxew91	167	18	and	and	CC
cord-015910-d9gxew91	167	19	healthy	healthy	JJ
cord-015910-d9gxew91	167	20	women	woman	NNS
cord-015910-d9gxew91	167	21	(	(	-LRB-
cord-015910-d9gxew91	167	22	Nilsson	Nilsson	NNP
cord-015910-d9gxew91	167	23	,	,	,
cord-015910-d9gxew91	167	24	Jovinge	Jovinge	NNP
cord-015910-d9gxew91	167	25	,	,	,
cord-015910-d9gxew91	167	26	Niemann	Niemann	NNP
cord-015910-d9gxew91	167	27	,	,	,
cord-015910-d9gxew91	167	28	Reneland	Reneland	NNP
cord-015910-d9gxew91	167	29	,	,	,
cord-015910-d9gxew91	167	30	&	&	CC
cord-015910-d9gxew91	167	31	Lithell	Lithell	NNP
cord-015910-d9gxew91	167	32	,	,	,
cord-015910-d9gxew91	167	33	1998	1998	CD
cord-015910-d9gxew91	167	34	;	;	:
cord-015910-d9gxew91	167	35	Yaqoob	Yaqoob	NNP
cord-015910-d9gxew91	167	36	,	,	,
cord-015910-d9gxew91	167	37	Newsholme	Newsholme	NNP
cord-015910-d9gxew91	167	38	,	,	,
cord-015910-d9gxew91	167	39	&	&	CC
cord-015910-d9gxew91	167	40	Calder	Calder	NNP
cord-015910-d9gxew91	167	41	,	,	,
cord-015910-d9gxew91	167	42	1999	1999	CD
cord-015910-d9gxew91	167	43	)	)	-RRB-
cord-015910-d9gxew91	167	44	.	.	.
cord-015910-d9gxew91	168	1	Leptin	leptin	NN
cord-015910-d9gxew91	168	2	has	have	VBZ
cord-015910-d9gxew91	168	3	been	be	VBN
cord-015910-d9gxew91	168	4	shown	show	VBN
cord-015910-d9gxew91	168	5	to	to	TO
cord-015910-d9gxew91	168	6	influence	influence	VB
cord-015910-d9gxew91	168	7	proinflammatory	proinflammatory	JJ
cord-015910-d9gxew91	168	8	cytokine	cytokine	NN
cord-015910-d9gxew91	168	9	production	production	NN
cord-015910-d9gxew91	168	10	(	(	-LRB-
cord-015910-d9gxew91	168	11	Fig	Fig	NNP
cord-015910-d9gxew91	168	12	.	.	.
cord-015910-d9gxew91	168	13	6	6	CD
cord-015910-d9gxew91	168	14	)	)	-RRB-
cord-015910-d9gxew91	168	15	.	.	.
cord-015910-d9gxew91	169	1	Thus	thus	RB
cord-015910-d9gxew91	169	2	,	,	,
cord-015910-d9gxew91	169	3	plasma	plasma	NN
cord-015910-d9gxew91	169	4	triglycerides	triglyceride	NNS
cord-015910-d9gxew91	169	5	,	,	,
cord-015910-d9gxew91	169	6	body	body	NN
cord-015910-d9gxew91	169	7	fat	fat	NN
cord-015910-d9gxew91	169	8	mass	mass	NN
cord-015910-d9gxew91	169	9	,	,	,
cord-015910-d9gxew91	169	10	and	and	CC
cord-015910-d9gxew91	169	11	inflammation	inflammation	NN
cord-015910-d9gxew91	169	12	may	may	MD
cord-015910-d9gxew91	169	13	be	be	VB
cord-015910-d9gxew91	169	14	loosely	loosely	RB
cord-015910-d9gxew91	169	15	associated	associate	VBN
cord-015910-d9gxew91	169	16	because	because	IN
cord-015910-d9gxew91	169	17	of	of	IN
cord-015910-d9gxew91	169	18	these	these	DT
cord-015910-d9gxew91	169	19	endocrine	endocrine	JJ
cord-015910-d9gxew91	169	20	relationships	relationship	NNS
cord-015910-d9gxew91	169	21	.	.	.
cord-015910-d9gxew91	170	1	A	a	DT
cord-015910-d9gxew91	170	2	number	number	NN
cord-015910-d9gxew91	170	3	of	of	IN
cord-015910-d9gxew91	170	4	population	population	NN
cord-015910-d9gxew91	170	5	studies	study	NNS
cord-015910-d9gxew91	170	6	have	have	VBP
cord-015910-d9gxew91	170	7	been	be	VBN
cord-015910-d9gxew91	170	8	conducted	conduct	VBN
cord-015910-d9gxew91	170	9	to	to	TO
cord-015910-d9gxew91	170	10	explore	explore	VB
cord-015910-d9gxew91	170	11	the	the	DT
cord-015910-d9gxew91	170	12	extent	extent	NN
cord-015910-d9gxew91	170	13	and	and	CC
cord-015910-d9gxew91	170	14	nature	nature	NN
cord-015910-d9gxew91	170	15	of	of	IN
cord-015910-d9gxew91	170	16	the	the	DT
cord-015910-d9gxew91	170	17	relationship	relationship	NN
cord-015910-d9gxew91	170	18	of	of	IN
cord-015910-d9gxew91	170	19	inflammation	inflammation	NN
cord-015910-d9gxew91	170	20	to	to	IN
cord-015910-d9gxew91	170	21	these	these	DT
cord-015910-d9gxew91	170	22	diseases	disease	NNS
cord-015910-d9gxew91	170	23	of	of	IN
cord-015910-d9gxew91	170	24	affluence	affluence	NN
cord-015910-d9gxew91	170	25	.	.	.
cord-015910-d9gxew91	171	1	The	the	DT
cord-015910-d9gxew91	171	2	studies	study	NNS
cord-015910-d9gxew91	171	3	have	have	VBP
cord-015910-d9gxew91	171	4	examined	examine	VBN
cord-015910-d9gxew91	171	5	populations	population	NNS
cord-015910-d9gxew91	171	6	in	in	IN
cord-015910-d9gxew91	171	7	which	which	WDT
cord-015910-d9gxew91	171	8	there	there	EX
cord-015910-d9gxew91	171	9	is	be	VBZ
cord-015910-d9gxew91	171	10	a	a	DT
cord-015910-d9gxew91	171	11	high	high	JJ
cord-015910-d9gxew91	171	12	incidence	incidence	NN
cord-015910-d9gxew91	171	13	of	of	IN
cord-015910-d9gxew91	171	14	insulin	insulin	NN
cord-015910-d9gxew91	171	15	insensitivity	insensitivity	NN
cord-015910-d9gxew91	171	16	,	,	,
cord-015910-d9gxew91	171	17	such	such	JJ
cord-015910-d9gxew91	171	18	as	as	IN
cord-015910-d9gxew91	171	19	Pima	Pima	NNP
cord-015910-d9gxew91	171	20	Indians	Indians	NNPS
cord-015910-d9gxew91	171	21	and	and	CC
cord-015910-d9gxew91	171	22	individuals	individual	NNS
cord-015910-d9gxew91	171	23	with	with	IN
cord-015910-d9gxew91	171	24	a	a	DT
cord-015910-d9gxew91	171	25	South	south	JJ
cord-015910-d9gxew91	171	26	Asian	asian	JJ
cord-015910-d9gxew91	171	27	background	background	NN
cord-015910-d9gxew91	171	28	.	.	.
cord-015910-d9gxew91	172	1	TNF	TNF	NNP
cord-015910-d9gxew91	172	2	-	-	HYPH
cord-015910-d9gxew91	172	3	o~	o~	NNP
cord-015910-d9gxew91	172	4	is	be	VBZ
cord-015910-d9gxew91	172	5	overexpressed	overexpresse	VBN
cord-015910-d9gxew91	172	6	in	in	IN
cord-015910-d9gxew91	172	7	adipose	adipose	NN
cord-015910-d9gxew91	172	8	and	and	CC
cord-015910-d9gxew91	172	9	muscle	muscle	NN
cord-015910-d9gxew91	172	10	tissues	tissue	NNS
cord-015910-d9gxew91	172	11	of	of	IN
cord-015910-d9gxew91	172	12	obese	obese	JJ
cord-015910-d9gxew91	172	13	subjects	subject	NNS
cord-015910-d9gxew91	172	14	compared	compare	VBN
cord-015910-d9gxew91	172	15	with	with	IN
cord-015910-d9gxew91	172	16	tissues	tissue	NNS
cord-015910-d9gxew91	172	17	from	from	IN
cord-015910-d9gxew91	172	18	lean	lean	JJ
cord-015910-d9gxew91	172	19	individuals	individual	NNS
cord-015910-d9gxew91	172	20	(	(	-LRB-
cord-015910-d9gxew91	172	21	Hotamisligl	Hotamisligl	NNP
cord-015910-d9gxew91	172	22	&	&	CC
cord-015910-d9gxew91	172	23	Spiegelman	Spiegelman	NNP
cord-015910-d9gxew91	172	24	.	.	.
cord-015910-d9gxew91	172	25	1994	1994	CD
cord-015910-d9gxew91	172	26	)	)	-RRB-
cord-015910-d9gxew91	172	27	.	.	.
cord-015910-d9gxew91	173	1	In	in	IN
cord-015910-d9gxew91	173	2	a	a	DT
cord-015910-d9gxew91	173	3	study	study	NN
cord-015910-d9gxew91	173	4	of	of	IN
cord-015910-d9gxew91	173	5	a	a	DT
cord-015910-d9gxew91	173	6	group	group	NN
cord-015910-d9gxew91	173	7	of	of	IN
cord-015910-d9gxew91	173	8	nondiabetic	nondiabetic	JJ
cord-015910-d9gxew91	173	9	Pima	Pima	NNP
cord-015910-d9gxew91	173	10	Indians	Indians	NNPS
cord-015910-d9gxew91	173	11	,	,	,
cord-015910-d9gxew91	173	12	employing	employ	VBG
cord-015910-d9gxew91	173	13	the	the	DT
cord-015910-d9gxew91	173	14	hyperinsulinemic	hyperinsulinemic	NNP
cord-015910-d9gxew91	173	15	euglycemic	euglycemic	NNP
cord-015910-d9gxew91	173	16	clamp	clamp	NN
cord-015910-d9gxew91	173	17	to	to	TO
cord-015910-d9gxew91	173	18	assess	assess	VB
cord-015910-d9gxew91	173	19	insulin	insulin	NN
cord-015910-d9gxew91	173	20	action	action	NN
cord-015910-d9gxew91	173	21	,	,	,
cord-015910-d9gxew91	173	22	strong	strong	JJ
cord-015910-d9gxew91	173	23	evidence	evidence	NN
cord-015910-d9gxew91	173	24	of	of	IN
cord-015910-d9gxew91	173	25	the	the	DT
cord-015910-d9gxew91	173	26	links	link	NNS
cord-015910-d9gxew91	173	27	between	between	IN
cord-015910-d9gxew91	173	28	inflammation	inflammation	NN
cord-015910-d9gxew91	173	29	,	,	,
cord-015910-d9gxew91	173	30	insulin	insulin	NN
cord-015910-d9gxew91	173	31	insensitivity	insensitivity	NN
cord-015910-d9gxew91	173	32	,	,	,
cord-015910-d9gxew91	173	33	and	and	CC
cord-015910-d9gxew91	173	34	obesity	obesity	NN
cord-015910-d9gxew91	173	35	emerged	emerge	VBD
cord-015910-d9gxew91	173	36	.	.	.
cord-015910-d9gxew91	174	1	Plasma	Plasma	NNP
cord-015910-d9gxew91	174	2	IL-6	IL-6	NNP
cord-015910-d9gxew91	174	3	was	be	VBD
cord-015910-d9gxew91	174	4	found	find	VBN
cord-015910-d9gxew91	174	5	to	to	TO
cord-015910-d9gxew91	174	6	be	be	VB
cord-015910-d9gxew91	174	7	related	relate	VBN
cord-015910-d9gxew91	174	8	positively	positively	RB
cord-015910-d9gxew91	174	9	to	to	IN
cord-015910-d9gxew91	174	10	adiposity	adiposity	NN
cord-015910-d9gxew91	174	11	and	and	CC
cord-015910-d9gxew91	174	12	negatively	negatively	RB
cord-015910-d9gxew91	174	13	to	to	TO
cord-015910-d9gxew91	174	14	insulin	insulin	NN
cord-015910-d9gxew91	174	15	sensitivity	sensitivity	NN
cord-015910-d9gxew91	174	16	.	.	.
cord-015910-d9gxew91	175	1	The	the	DT
cord-015910-d9gxew91	175	2	investigators	investigator	NNS
cord-015910-d9gxew91	175	3	concluded	conclude	VBD
cord-015910-d9gxew91	175	4	that	that	IN
cord-015910-d9gxew91	175	5	the	the	DT
cord-015910-d9gxew91	175	6	relationship	relationship	NN
cord-015910-d9gxew91	175	7	between	between	IN
cord-015910-d9gxew91	175	8	IL-6	IL-6	NNP
cord-015910-d9gxew91	175	9	and	and	CC
cord-015910-d9gxew91	175	10	insulin	insulin	NN
cord-015910-d9gxew91	175	11	action	action	NN
cord-015910-d9gxew91	175	12	appeared	appear	VBD
cord-015910-d9gxew91	175	13	to	to	TO
cord-015910-d9gxew91	175	14	be	be	VB
cord-015910-d9gxew91	175	15	mediated	mediate	VBN
cord-015910-d9gxew91	175	16	through	through	IN
cord-015910-d9gxew91	175	17	adiposity	adiposity	NN
cord-015910-d9gxew91	175	18	(	(	-LRB-
cord-015910-d9gxew91	175	19	Vozarova	Vozarova	NNP
cord-015910-d9gxew91	175	20	,	,	,
cord-015910-d9gxew91	175	21	Weyer	Weyer	NNP
cord-015910-d9gxew91	175	22	,	,	,
cord-015910-d9gxew91	175	23	&	&	CC
cord-015910-d9gxew91	175	24	Hanson	Hanson	NNP
cord-015910-d9gxew91	175	25	,	,	,
cord-015910-d9gxew91	175	26	2001	2001	CD
cord-015910-d9gxew91	175	27	)	)	-RRB-
cord-015910-d9gxew91	175	28	.	.	.
cord-015910-d9gxew91	176	1	A	a	DT
cord-015910-d9gxew91	176	2	number	number	NN
cord-015910-d9gxew91	176	3	of	of	IN
cord-015910-d9gxew91	176	4	studies	study	NNS
cord-015910-d9gxew91	176	5	have	have	VBP
cord-015910-d9gxew91	176	6	looked	look	VBN
cord-015910-d9gxew91	176	7	at	at	IN
cord-015910-d9gxew91	176	8	the	the	DT
cord-015910-d9gxew91	176	9	extent	extent	NN
cord-015910-d9gxew91	176	10	of	of	IN
cord-015910-d9gxew91	176	11	the	the	DT
cord-015910-d9gxew91	176	12	interaction	interaction	NN
cord-015910-d9gxew91	176	13	between	between	IN
cord-015910-d9gxew91	176	14	insulin	insulin	NN
cord-015910-d9gxew91	176	15	insensitivity	insensitivity	NN
cord-015910-d9gxew91	176	16	and	and	CC
cord-015910-d9gxew91	176	17	inflammation	inflammation	NN
cord-015910-d9gxew91	176	18	by	by	IN
cord-015910-d9gxew91	176	19	studying	study	VBG
cord-015910-d9gxew91	176	20	the	the	DT
cord-015910-d9gxew91	176	21	extreme	extreme	JJ
cord-015910-d9gxew91	176	22	form	form	NN
cord-015910-d9gxew91	176	23	of	of	IN
cord-015910-d9gxew91	176	24	diabetes	diabetes	NN
cord-015910-d9gxew91	176	25	,	,	,
cord-015910-d9gxew91	176	26	type	type	NN
cord-015910-d9gxew91	176	27	1	1	CD
cord-015910-d9gxew91	176	28	diabetes	diabetes	NN
cord-015910-d9gxew91	176	29	mellitus	mellitus	NN
cord-015910-d9gxew91	176	30	.	.	.
cord-015910-d9gxew91	177	1	A	a	DT
cord-015910-d9gxew91	177	2	study	study	NN
cord-015910-d9gxew91	177	3	assessed	assess	VBD
cord-015910-d9gxew91	177	4	endothelial	endothelial	JJ
cord-015910-d9gxew91	177	5	cell	cell	NN
cord-015910-d9gxew91	177	6	perturbation	perturbation	NN
cord-015910-d9gxew91	177	7	by	by	IN
cord-015910-d9gxew91	177	8	measurement	measurement	NN
cord-015910-d9gxew91	177	9	of	of	IN
cord-015910-d9gxew91	177	10	von	von	NNP
cord-015910-d9gxew91	177	11	Willebrand	Willebrand	NNP
cord-015910-d9gxew91	177	12	factor	factor	NN
cord-015910-d9gxew91	177	13	and	and	CC
cord-015910-d9gxew91	177	14	tissue	tissue	NN
cord-015910-d9gxew91	177	15	-	-	HYPH
cord-015910-d9gxew91	177	16	plasminogen	plasminogen	NN
cord-015910-d9gxew91	177	17	activator	activator	NN
cord-015910-d9gxew91	177	18	(	(	-LRB-
cord-015910-d9gxew91	177	19	t	t	NNP
cord-015910-d9gxew91	177	20	-	-	HYPH
cord-015910-d9gxew91	177	21	PA	PA	NNP
cord-015910-d9gxew91	177	22	)	)	-RRB-
cord-015910-d9gxew91	177	23	,	,	,
cord-015910-d9gxew91	177	24	in	in	IN
cord-015910-d9gxew91	177	25	type	type	NN
cord-015910-d9gxew91	177	26	1	1	CD
cord-015910-d9gxew91	177	27	diabetics	diabetic	NNS
cord-015910-d9gxew91	177	28	who	who	WP
cord-015910-d9gxew91	177	29	had	have	VBD
cord-015910-d9gxew91	177	30	had	have	VBN
cord-015910-d9gxew91	177	31	the	the	DT
cord-015910-d9gxew91	177	32	disease	disease	NN
cord-015910-d9gxew91	177	33	for	for	IN
cord-015910-d9gxew91	177	34	<	<	NNP
cord-015910-d9gxew91	177	35	1	1	CD
cord-015910-d9gxew91	177	36	or	or	CC
cord-015910-d9gxew91	177	37	>	>	NN
cord-015910-d9gxew91	177	38	1	1	CD
cord-015910-d9gxew91	177	39	yr	yr	NN
cord-015910-d9gxew91	177	40	.	.	.
cord-015910-d9gxew91	178	1	Compared	compare	VBN
cord-015910-d9gxew91	178	2	with	with	IN
cord-015910-d9gxew91	178	3	normal	normal	JJ
cord-015910-d9gxew91	178	4	subjects	subject	NNS
cord-015910-d9gxew91	178	5	,	,	,
cord-015910-d9gxew91	178	6	children	child	NNS
cord-015910-d9gxew91	178	7	with	with	IN
cord-015910-d9gxew91	178	8	diabetes	diabetes	NN
cord-015910-d9gxew91	178	9	for	for	IN
cord-015910-d9gxew91	178	10	<	<	NNP
cord-015910-d9gxew91	178	11	lyear	lyear	NNP
cord-015910-d9gxew91	178	12	had	have	VBD
cord-015910-d9gxew91	178	13	the	the	DT
cord-015910-d9gxew91	178	14	highest	high	JJS
cord-015910-d9gxew91	178	15	concentrations	concentration	NNS
cord-015910-d9gxew91	178	16	of	of	IN
cord-015910-d9gxew91	178	17	von	von	NNP
cord-015910-d9gxew91	178	18	Willebrand	Willebrand	NNP
cord-015910-d9gxew91	178	19	factor	factor	NN
cord-015910-d9gxew91	178	20	,	,	,
cord-015910-d9gxew91	178	21	indicating	indicate	VBG
cord-015910-d9gxew91	178	22	that	that	IN
cord-015910-d9gxew91	178	23	endothelial	endothelial	JJ
cord-015910-d9gxew91	178	24	perturbation	perturbation	NN
cord-015910-d9gxew91	178	25	represents	represent	VBZ
cord-015910-d9gxew91	178	26	an	an	DT
cord-015910-d9gxew91	178	27	early	early	JJ
cord-015910-d9gxew91	178	28	event	event	NN
cord-015910-d9gxew91	178	29	in	in	IN
cord-015910-d9gxew91	178	30	type	type	NN
cord-015910-d9gxew91	178	31	1	1	CD
cord-015910-d9gxew91	178	32	diabetes	diabetes	NN
cord-015910-d9gxew91	178	33	(	(	-LRB-
cord-015910-d9gxew91	178	34	Romano	Romano	NNP
cord-015910-d9gxew91	178	35	,	,	,
cord-015910-d9gxew91	178	36	Pomilio	Pomilio	NNP
cord-015910-d9gxew91	178	37	,	,	,
cord-015910-d9gxew91	178	38	&	&	CC
cord-015910-d9gxew91	178	39	Vigneri	Vigneri	NNP
cord-015910-d9gxew91	178	40	,	,	,
cord-015910-d9gxew91	178	41	2001	2001	CD
cord-015910-d9gxew91	178	42	)	)	-RRB-
cord-015910-d9gxew91	178	43	.	.	.
cord-015910-d9gxew91	179	1	Studies	study	NNS
cord-015910-d9gxew91	179	2	that	that	WDT
cord-015910-d9gxew91	179	3	have	have	VBP
cord-015910-d9gxew91	179	4	attempted	attempt	VBN
cord-015910-d9gxew91	179	5	either	either	CC
cord-015910-d9gxew91	179	6	to	to	TO
cord-015910-d9gxew91	179	7	remove	remove	VB
cord-015910-d9gxew91	179	8	the	the	DT
cord-015910-d9gxew91	179	9	cause	cause	NN
cord-015910-d9gxew91	179	10	of	of	IN
cord-015910-d9gxew91	179	11	inflammation	inflammation	NN
cord-015910-d9gxew91	179	12	,	,	,
cord-015910-d9gxew91	179	13	to	to	TO
cord-015910-d9gxew91	179	14	lower	lower	VB
cord-015910-d9gxew91	179	15	plasma	plasma	NN
cord-015910-d9gxew91	179	16	lipids	lipid	NNS
cord-015910-d9gxew91	179	17	,	,	,
cord-015910-d9gxew91	179	18	or	or	CC
cord-015910-d9gxew91	179	19	improve	improve	VB
cord-015910-d9gxew91	179	20	insulin	insulin	NN
cord-015910-d9gxew91	179	21	sensitivity	sensitivity	NN
cord-015910-d9gxew91	179	22	have	have	VBP
cord-015910-d9gxew91	179	23	supported	support	VBN
cord-015910-d9gxew91	179	24	the	the	DT
cord-015910-d9gxew91	179	25	hypothesis	hypothesis	NN
cord-015910-d9gxew91	179	26	that	that	IN
cord-015910-d9gxew91	179	27	inflammation	inflammation	NN
cord-015910-d9gxew91	179	28	,	,	,
cord-015910-d9gxew91	179	29	insulin	insulin	NN
cord-015910-d9gxew91	179	30	sensitivity	sensitivity	NN
cord-015910-d9gxew91	179	31	,	,	,
cord-015910-d9gxew91	179	32	and	and	CC
cord-015910-d9gxew91	179	33	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	179	34	are	be	VBP
cord-015910-d9gxew91	179	35	intimately	intimately	RB
cord-015910-d9gxew91	179	36	interlinked	interlink	VBN
cord-015910-d9gxew91	179	37	.	.	.
cord-015910-d9gxew91	180	1	When	when	WRB
cord-015910-d9gxew91	180	2	a	a	DT
cord-015910-d9gxew91	180	3	study	study	NN
cord-015910-d9gxew91	180	4	of	of	IN
cord-015910-d9gxew91	180	5	the	the	DT
cord-015910-d9gxew91	180	6	potential	potential	JJ
cord-015910-d9gxew91	180	7	anti	anti	JJ
cord-015910-d9gxew91	180	8	-	-	JJ
cord-015910-d9gxew91	180	9	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	180	10	effect	effect	NN
cord-015910-d9gxew91	180	11	of	of	IN
cord-015910-d9gxew91	180	12	weight	weight	NN
cord-015910-d9gxew91	180	13	loss	loss	NN
cord-015910-d9gxew91	180	14	was	be	VBD
cord-015910-d9gxew91	180	15	conducted	conduct	VBN
cord-015910-d9gxew91	180	16	in	in	IN
cord-015910-d9gxew91	180	17	obese	obese	JJ
cord-015910-d9gxew91	180	18	women	woman	NNS
cord-015910-d9gxew91	180	19	,	,	,
cord-015910-d9gxew91	180	20	it	-PRON-	PRP
cord-015910-d9gxew91	180	21	was	be	VBD
cord-015910-d9gxew91	180	22	found	find	VBN
cord-015910-d9gxew91	180	23	that	that	IN
cord-015910-d9gxew91	180	24	a	a	DT
cord-015910-d9gxew91	180	25	1	1	CD
cord-015910-d9gxew91	180	26	yr	yr	NN
cord-015910-d9gxew91	180	27	weight	weight	NN
cord-015910-d9gxew91	180	28	-	-	HYPH
cord-015910-d9gxew91	180	29	reduction	reduction	NN
cord-015910-d9gxew91	180	30	program	program	NN
cord-015910-d9gxew91	180	31	resulted	result	VBD
cord-015910-d9gxew91	180	32	in	in	IN
cord-015910-d9gxew91	180	33	lowering	lowering	NN
cord-015910-d9gxew91	180	34	of	of	IN
cord-015910-d9gxew91	180	35	plasma	plasma	NN
cord-015910-d9gxew91	180	36	IL-6	IL-6	NNP
cord-015910-d9gxew91	180	37	,	,	,
cord-015910-d9gxew91	180	38	TNF	TNF	NNP
cord-015910-d9gxew91	180	39	-	-	HYPH
cord-015910-d9gxew91	180	40	cx	cx	NNP
cord-015910-d9gxew91	180	41	,	,	,
cord-015910-d9gxew91	180	42	and	and	CC
cord-015910-d9gxew91	180	43	adhesion	adhesion	NN
cord-015910-d9gxew91	180	44	molecule	molecule	NN
cord-015910-d9gxew91	180	45	concentrations	concentration	NNS
cord-015910-d9gxew91	180	46	(	(	-LRB-
cord-015910-d9gxew91	180	47	Ziccardi	Ziccardi	NNPS
cord-015910-d9gxew91	180	48	,	,	,
cord-015910-d9gxew91	180	49	Nappo	Nappo	NNP
cord-015910-d9gxew91	180	50	,	,	,
cord-015910-d9gxew91	180	51	&	&	CC
cord-015910-d9gxew91	180	52	Giugliano	Giugliano	NNP
cord-015910-d9gxew91	180	53	,	,	,
cord-015910-d9gxew91	180	54	2002	2002	CD
cord-015910-d9gxew91	180	55	)	)	-RRB-
cord-015910-d9gxew91	180	56	.	.	.
cord-015910-d9gxew91	181	1	Since	since	IN
cord-015910-d9gxew91	181	2	the	the	DT
cord-015910-d9gxew91	181	3	1990s	1990s	CD
cord-015910-d9gxew91	181	4	large	large	JJ
cord-015910-d9gxew91	181	5	population	population	NN
cord-015910-d9gxew91	181	6	studies	study	NNS
cord-015910-d9gxew91	181	7	have	have	VBP
cord-015910-d9gxew91	181	8	indicated	indicate	VBN
cord-015910-d9gxew91	181	9	that	that	IN
cord-015910-d9gxew91	181	10	inflammation	inflammation	NN
cord-015910-d9gxew91	181	11	plays	play	VBZ
cord-015910-d9gxew91	181	12	a	a	DT
cord-015910-d9gxew91	181	13	key	key	JJ
cord-015910-d9gxew91	181	14	role	role	NN
cord-015910-d9gxew91	181	15	in	in	IN
cord-015910-d9gxew91	181	16	cardiovascular	cardiovascular	JJ
cord-015910-d9gxew91	181	17	disease	disease	NN
cord-015910-d9gxew91	181	18	(	(	-LRB-
cord-015910-d9gxew91	181	19	CVD	CVD	NNP
cord-015910-d9gxew91	181	20	)	)	-RRB-
cord-015910-d9gxew91	182	1	(	(	-LRB-
cord-015910-d9gxew91	182	2	Grimble	Grimble	NNP
cord-015910-d9gxew91	182	3	,	,	,
cord-015910-d9gxew91	182	4	1990	1990	CD
cord-015910-d9gxew91	182	5	;	;	:
cord-015910-d9gxew91	182	6	Ross	Ross	NNP
cord-015910-d9gxew91	182	7	,	,	,
cord-015910-d9gxew91	182	8	1993	1993	CD
cord-015910-d9gxew91	182	9	)	)	-RRB-
cord-015910-d9gxew91	182	10	.	.	.
cord-015910-d9gxew91	183	1	Periodontal	periodontal	JJ
cord-015910-d9gxew91	183	2	disease	disease	NN
cord-015910-d9gxew91	183	3	and	and	CC
cord-015910-d9gxew91	183	4	other	other	JJ
cord-015910-d9gxew91	183	5	low	low	JJ
cord-015910-d9gxew91	183	6	-	-	HYPH
cord-015910-d9gxew91	183	7	grade	grade	NN
cord-015910-d9gxew91	183	8	infections	infection	NNS
cord-015910-d9gxew91	183	9	,	,	,
cord-015910-d9gxew91	183	10	such	such	JJ
cord-015910-d9gxew91	183	11	as	as	IN
cord-015910-d9gxew91	183	12	Chlamydia	Chlamydia	NNP
cord-015910-d9gxew91	183	13	pneumoniae	pneumoniae	NN
cord-015910-d9gxew91	183	14	infection	infection	NN
cord-015910-d9gxew91	183	15	,	,	,
cord-015910-d9gxew91	183	16	have	have	VBP
cord-015910-d9gxew91	183	17	been	be	VBN
cord-015910-d9gxew91	183	18	linked	link	VBN
cord-015910-d9gxew91	183	19	closely	closely	RB
cord-015910-d9gxew91	183	20	with	with	IN
cord-015910-d9gxew91	183	21	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	183	22	.	.	.
cord-015910-d9gxew91	184	1	Development	development	NN
cord-015910-d9gxew91	184	2	of	of	IN
cord-015910-d9gxew91	184	3	atherosclerotic	atherosclerotic	JJ
cord-015910-d9gxew91	184	4	plaques	plaque	NNS
cord-015910-d9gxew91	184	5	to	to	TO
cord-015910-d9gxew91	184	6	which	which	WDT
cord-015910-d9gxew91	184	7	macrophages	macrophage	NNS
cord-015910-d9gxew91	184	8	have	have	VBP
cord-015910-d9gxew91	184	9	already	already	RB
cord-015910-d9gxew91	184	10	been	be	VBN
cord-015910-d9gxew91	184	11	recruited	recruit	VBN
cord-015910-d9gxew91	184	12	occurs	occur	VBZ
cord-015910-d9gxew91	184	13	by	by	IN
cord-015910-d9gxew91	184	14	cytokines	cytokine	NNS
cord-015910-d9gxew91	184	15	inducing	induce	VBG
cord-015910-d9gxew91	184	16	hypertriglyceridemia	hypertriglyceridemia	NN
cord-015910-d9gxew91	184	17	and	and	CC
cord-015910-d9gxew91	184	18	hypercholesterolemia	hypercholesterolemia	NN
cord-015910-d9gxew91	184	19	(	(	-LRB-
cord-015910-d9gxew91	184	20	Kol	Kol	NNP
cord-015910-d9gxew91	184	21	,	,	,
cord-015910-d9gxew91	184	22	Sukhova	Sukhova	NNP
cord-015910-d9gxew91	184	23	,	,	,
cord-015910-d9gxew91	184	24	Lichtman	Lichtman	NNP
cord-015910-d9gxew91	184	25	,	,	,
cord-015910-d9gxew91	184	26	&	&	CC
cord-015910-d9gxew91	184	27	Libby	Libby	NNP
cord-015910-d9gxew91	184	28	,	,	,
cord-015910-d9gxew91	184	29	1998	1998	CD
cord-015910-d9gxew91	184	30	;	;	:
cord-015910-d9gxew91	184	31	Saldeen	Saldeen	NNP
cord-015910-d9gxew91	184	32	&	&	CC
cord-015910-d9gxew91	184	33	Rand	Rand	NNP
cord-015910-d9gxew91	184	34	1998	1998	CD
cord-015910-d9gxew91	184	35	)	)	-RRB-
cord-015910-d9gxew91	184	36	.	.	.
cord-015910-d9gxew91	185	1	Chlamydial	chlamydial	JJ
cord-015910-d9gxew91	185	2	infection	infection	NN
cord-015910-d9gxew91	185	3	induces	induce	VBZ
cord-015910-d9gxew91	185	4	production	production	NN
cord-015910-d9gxew91	185	5	of	of	IN
cord-015910-d9gxew91	185	6	TNF-~.	TNF-~.	NNP
cord-015910-d9gxew91	186	1	The	the	DT
cord-015910-d9gxew91	186	2	cytokine	cytokine	NN
cord-015910-d9gxew91	186	3	inhibits	inhibit	VBZ
cord-015910-d9gxew91	186	4	the	the	DT
cord-015910-d9gxew91	186	5	action	action	NN
cord-015910-d9gxew91	186	6	of	of	IN
cord-015910-d9gxew91	186	7	lipoprotein	lipoprotein	NN
cord-015910-d9gxew91	186	8	lipase	lipase	NN
cord-015910-d9gxew91	186	9	,	,	,
cord-015910-d9gxew91	186	10	leading	lead	VBG
cord-015910-d9gxew91	186	11	to	to	IN
cord-015910-d9gxew91	186	12	changed	change	VBN
cord-015910-d9gxew91	186	13	lipid	lipid	NN
cord-015910-d9gxew91	186	14	metabolism	metabolism	NN
cord-015910-d9gxew91	186	15	,	,	,
cord-015910-d9gxew91	186	16	elevation	elevation	NN
cord-015910-d9gxew91	186	17	of	of	IN
cord-015910-d9gxew91	186	18	serum	serum	NN
cord-015910-d9gxew91	186	19	triglycerides	triglyceride	NNS
cord-015910-d9gxew91	186	20	,	,	,
cord-015910-d9gxew91	186	21	and	and	CC
cord-015910-d9gxew91	186	22	a	a	DT
cord-015910-d9gxew91	186	23	decrease	decrease	NN
cord-015910-d9gxew91	186	24	in	in	IN
cord-015910-d9gxew91	186	25	serum	serum	NN
cord-015910-d9gxew91	186	26	high	high	JJ
cord-015910-d9gxew91	186	27	-	-	HYPH
cord-015910-d9gxew91	186	28	density	density	NN
cord-015910-d9gxew91	186	29	lipoprotein	lipoprotein	NN
cord-015910-d9gxew91	186	30	(	(	-LRB-
cord-015910-d9gxew91	186	31	HDL	HDL	NNP
cord-015910-d9gxew91	186	32	)	)	-RRB-
cord-015910-d9gxew91	186	33	cholesterol	cholesterol	NN
cord-015910-d9gxew91	186	34	,	,	,
cord-015910-d9gxew91	186	35	thereby	thereby	RB
cord-015910-d9gxew91	186	36	exerting	exert	VBG
cord-015910-d9gxew91	186	37	an	an	DT
cord-015910-d9gxew91	186	38	atherogenic	atherogenic	JJ
cord-015910-d9gxew91	186	39	influence	influence	NN
cord-015910-d9gxew91	186	40	(	(	-LRB-
cord-015910-d9gxew91	186	41	Arrnitage	Arrnitage	NNP
cord-015910-d9gxew91	186	42	,	,	,
cord-015910-d9gxew91	186	43	2000	2000	CD
cord-015910-d9gxew91	186	44	)	)	-RRB-
cord-015910-d9gxew91	186	45	.	.	.
cord-015910-d9gxew91	187	1	In	in	IN
cord-015910-d9gxew91	187	2	the	the	DT
cord-015910-d9gxew91	187	3	Bruneck	Bruneck	NNP
cord-015910-d9gxew91	187	4	study	study	NN
cord-015910-d9gxew91	187	5	,	,	,
cord-015910-d9gxew91	187	6	raised	raise	VBD
cord-015910-d9gxew91	187	7	plasma	plasma	NN
cord-015910-d9gxew91	187	8	bacterial	bacterial	JJ
cord-015910-d9gxew91	187	9	lipopolysaccharide	lipopolysaccharide	NN
cord-015910-d9gxew91	187	10	(	(	-LRB-
cord-015910-d9gxew91	187	11	LPS	LPS	NNP
cord-015910-d9gxew91	187	12	)	)	-RRB-
cord-015910-d9gxew91	187	13	was	be	VBD
cord-015910-d9gxew91	187	14	associated	associate	VBN
cord-015910-d9gxew91	187	15	with	with	IN
cord-015910-d9gxew91	187	16	an	an	DT
cord-015910-d9gxew91	187	17	increased	increase	VBN
cord-015910-d9gxew91	187	18	rate	rate	NN
cord-015910-d9gxew91	187	19	of	of	IN
cord-015910-d9gxew91	187	20	thickening	thickening	NN
cord-015910-d9gxew91	187	21	of	of	IN
cord-015910-d9gxew91	187	22	the	the	DT
cord-015910-d9gxew91	187	23	coronary	coronary	JJ
cord-015910-d9gxew91	187	24	artery	artery	NN
cord-015910-d9gxew91	187	25	intima	intima	NN
cord-015910-d9gxew91	187	26	.	.	.
cord-015910-d9gxew91	188	1	Smoking	smoking	NN
cord-015910-d9gxew91	188	2	,	,	,
cord-015910-d9gxew91	188	3	a	a	DT
cord-015910-d9gxew91	188	4	further	further	JJ
cord-015910-d9gxew91	188	5	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	188	6	stress	stress	NN
cord-015910-d9gxew91	188	7	,	,	,
cord-015910-d9gxew91	188	8	exacerbated	exacerbate	VBD
cord-015910-d9gxew91	188	9	this	this	DT
cord-015910-d9gxew91	188	10	effect	effect	NN
cord-015910-d9gxew91	188	11	(	(	-LRB-
cord-015910-d9gxew91	188	12	Williet	Williet	NNP
cord-015910-d9gxew91	188	13	&	&	CC
cord-015910-d9gxew91	188	14	Kiechl	Kiechl	NNP
cord-015910-d9gxew91	188	15	,	,	,
cord-015910-d9gxew91	188	16	2000	2000	CD
cord-015910-d9gxew91	188	17	)	)	-RRB-
cord-015910-d9gxew91	188	18	.	.	.
cord-015910-d9gxew91	189	1	LPS	LPS	NNP
cord-015910-d9gxew91	189	2	binds	bind	VBZ
cord-015910-d9gxew91	189	3	in	in	IN
cord-015910-d9gxew91	189	4	human	human	JJ
cord-015910-d9gxew91	189	5	serum	serum	NN
cord-015910-d9gxew91	189	6	to	to	IN
cord-015910-d9gxew91	189	7	both	both	CC
cord-015910-d9gxew91	189	8	low	low	JJ
cord-015910-d9gxew91	189	9	-	-	HYPH
cord-015910-d9gxew91	189	10	density	density	NN
cord-015910-d9gxew91	189	11	lipoprotein	lipoprotein	NN
cord-015910-d9gxew91	189	12	(	(	-LRB-
cord-015910-d9gxew91	189	13	LDL	LDL	NNP
cord-015910-d9gxew91	189	14	)	)	-RRB-
cord-015910-d9gxew91	189	15	and	and	CC
cord-015910-d9gxew91	189	16	HDL	HDL	NNP
cord-015910-d9gxew91	189	17	cholesterol	cholesterol	NN
cord-015910-d9gxew91	189	18	and	and	CC
cord-015910-d9gxew91	189	19	makes	make	VBZ
cord-015910-d9gxew91	189	20	LDL	ldl	NN
cord-015910-d9gxew91	189	21	cholesterol	cholesterol	NN
cord-015910-d9gxew91	189	22	immunogenic	immunogenic	JJ
cord-015910-d9gxew91	189	23	or	or	CC
cord-015910-d9gxew91	189	24	toxic	toxic	JJ
cord-015910-d9gxew91	189	25	to	to	IN
cord-015910-d9gxew91	189	26	endothelial	endothelial	JJ
cord-015910-d9gxew91	189	27	cells	cell	NNS
cord-015910-d9gxew91	189	28	.	.	.
cord-015910-d9gxew91	190	1	Thus	thus	RB
cord-015910-d9gxew91	190	2	,	,	,
cord-015910-d9gxew91	190	3	the	the	DT
cord-015910-d9gxew91	190	4	link	link	NN
cord-015910-d9gxew91	190	5	between	between	IN
cord-015910-d9gxew91	190	6	specific	specific	JJ
cord-015910-d9gxew91	190	7	infections	infection	NNS
cord-015910-d9gxew91	190	8	and	and	CC
cord-015910-d9gxew91	190	9	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	190	10	may	may	MD
cord-015910-d9gxew91	190	11	be	be	VB
cord-015910-d9gxew91	190	12	a	a	DT
cord-015910-d9gxew91	190	13	nonspecific	nonspecific	JJ
cord-015910-d9gxew91	190	14	effect	effect	NN
cord-015910-d9gxew91	190	15	of	of	IN
cord-015910-d9gxew91	190	16	chronic	chronic	JJ
cord-015910-d9gxew91	190	17	inflammation	inflammation	NN
cord-015910-d9gxew91	190	18	on	on	IN
cord-015910-d9gxew91	190	19	the	the	DT
cord-015910-d9gxew91	190	20	atherosclerotic	atherosclerotic	JJ
cord-015910-d9gxew91	190	21	process	process	NN
cord-015910-d9gxew91	190	22	.	.	.
cord-015910-d9gxew91	191	1	It	-PRON-	PRP
cord-015910-d9gxew91	191	2	is	be	VBZ
cord-015910-d9gxew91	191	3	well	well	RB
cord-015910-d9gxew91	191	4	recognized	recognize	VBN
cord-015910-d9gxew91	191	5	that	that	IN
cord-015910-d9gxew91	191	6	alterations	alteration	NNS
cord-015910-d9gxew91	191	7	in	in	IN
cord-015910-d9gxew91	191	8	plasma	plasma	NN
cord-015910-d9gxew91	191	9	protein	protein	NN
cord-015910-d9gxew91	191	10	concentrations	concentration	NNS
cord-015910-d9gxew91	191	11	invariably	invariably	RB
cord-015910-d9gxew91	191	12	occur	occur	VBP
cord-015910-d9gxew91	191	13	among	among	IN
cord-015910-d9gxew91	191	14	the	the	DT
cord-015910-d9gxew91	191	15	many	many	JJ
cord-015910-d9gxew91	191	16	metabolic	metabolic	JJ
cord-015910-d9gxew91	191	17	changes	change	NNS
cord-015910-d9gxew91	191	18	that	that	WDT
cord-015910-d9gxew91	191	19	occur	occur	VBP
cord-015910-d9gxew91	191	20	during	during	IN
cord-015910-d9gxew91	191	21	inflammation	inflammation	NN
cord-015910-d9gxew91	191	22	.	.	.
cord-015910-d9gxew91	192	1	Proteins	protein	NNS
cord-015910-d9gxew91	192	2	that	that	WDT
cord-015910-d9gxew91	192	3	increase	increase	VBP
cord-015910-d9gxew91	192	4	during	during	IN
cord-015910-d9gxew91	192	5	inflammation	inflammation	NN
cord-015910-d9gxew91	192	6	(	(	-LRB-
cord-015910-d9gxew91	192	7	positive	positive	JJ
cord-015910-d9gxew91	192	8	acute	acute	JJ
cord-015910-d9gxew91	192	9	-	-	HYPH
cord-015910-d9gxew91	192	10	phase	phase	NN
cord-015910-d9gxew91	192	11	proteins	protein	NNS
cord-015910-d9gxew91	192	12	,	,	,
cord-015910-d9gxew91	193	1	e.g.	e.g.	RB
cord-015910-d9gxew91	193	2	,	,	,
cord-015910-d9gxew91	193	3	CRP	CRP	NNP
cord-015910-d9gxew91	193	4	and	and	CC
cord-015910-d9gxew91	193	5	fibrinogen	fibrinogen	NN
cord-015910-d9gxew91	193	6	)	)	-RRB-
cord-015910-d9gxew91	193	7	and	and	CC
cord-015910-d9gxew91	193	8	those	those	DT
cord-015910-d9gxew91	193	9	that	that	WDT
cord-015910-d9gxew91	193	10	decrease	decrease	NN
cord-015910-d9gxew91	193	11	(	(	-LRB-
cord-015910-d9gxew91	193	12	negative	negative	JJ
cord-015910-d9gxew91	193	13	acute	acute	JJ
cord-015910-d9gxew91	193	14	-	-	HYPH
cord-015910-d9gxew91	193	15	phase	phase	NN
cord-015910-d9gxew91	193	16	proteins	protein	NNS
cord-015910-d9gxew91	193	17	,	,	,
cord-015910-d9gxew91	193	18	e.g.	e.g.	RB
cord-015910-d9gxew91	193	19	,	,	,
cord-015910-d9gxew91	193	20	serum	serum	NN
cord-015910-d9gxew91	193	21	albumin	albumin	NN
cord-015910-d9gxew91	193	22	and	and	CC
cord-015910-d9gxew91	193	23	retinolbinding	retinolbinde	VBG
cord-015910-d9gxew91	193	24	protein	protein	NN
cord-015910-d9gxew91	193	25	)	)	-RRB-
cord-015910-d9gxew91	193	26	are	be	VBP
cord-015910-d9gxew91	193	27	used	use	VBN
cord-015910-d9gxew91	193	28	to	to	TO
cord-015910-d9gxew91	193	29	diagnose	diagnose	VB
cord-015910-d9gxew91	193	30	inflammation	inflammation	NN
cord-015910-d9gxew91	193	31	in	in	IN
cord-015910-d9gxew91	193	32	population	population	NN
cord-015910-d9gxew91	193	33	nutritional	nutritional	JJ
cord-015910-d9gxew91	193	34	surveys	survey	NNS
cord-015910-d9gxew91	193	35	.	.	.
cord-015910-d9gxew91	194	1	The	the	DT
cord-015910-d9gxew91	194	2	early	early	JJ
cord-015910-d9gxew91	194	3	indications	indication	NNS
cord-015910-d9gxew91	194	4	that	that	IN
cord-015910-d9gxew91	194	5	inflammation	inflammation	NN
cord-015910-d9gxew91	194	6	was	be	VBD
cord-015910-d9gxew91	194	7	involved	involve	VBN
cord-015910-d9gxew91	194	8	in	in	IN
cord-015910-d9gxew91	194	9	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	194	10	came	come	VBD
cord-015910-d9gxew91	194	11	from	from	IN
cord-015910-d9gxew91	194	12	the	the	DT
cord-015910-d9gxew91	194	13	findings	finding	NNS
cord-015910-d9gxew91	194	14	that	that	IN
cord-015910-d9gxew91	194	15	there	there	EX
cord-015910-d9gxew91	194	16	were	be	VBD
cord-015910-d9gxew91	194	17	links	link	NNS
cord-015910-d9gxew91	194	18	between	between	IN
cord-015910-d9gxew91	194	19	concentrations	concentration	NNS
cord-015910-d9gxew91	194	20	of	of	IN
cord-015910-d9gxew91	194	21	positive	positive	JJ
cord-015910-d9gxew91	194	22	and	and	CC
cord-015910-d9gxew91	194	23	negative	negative	JJ
cord-015910-d9gxew91	194	24	acute	acute	JJ
cord-015910-d9gxew91	194	25	-	-	HYPH
cord-015910-d9gxew91	194	26	phase	phase	NN
cord-015910-d9gxew91	194	27	proteins	protein	NNS
cord-015910-d9gxew91	194	28	in	in	IN
cord-015910-d9gxew91	194	29	blood	blood	NN
cord-015910-d9gxew91	194	30	and	and	CC
cord-015910-d9gxew91	194	31	CVD	CVD	NNP
cord-015910-d9gxew91	194	32	(	(	-LRB-
cord-015910-d9gxew91	194	33	Grimble	Grimble	NNP
cord-015910-d9gxew91	194	34	,	,	,
cord-015910-d9gxew91	194	35	1990	1990	CD
cord-015910-d9gxew91	194	36	)	)	-RRB-
cord-015910-d9gxew91	194	37	.	.	.
cord-015910-d9gxew91	195	1	In	in	IN
cord-015910-d9gxew91	195	2	the	the	DT
cord-015910-d9gxew91	195	3	Bruneck	Bruneck	NNP
cord-015910-d9gxew91	195	4	study	study	NN
cord-015910-d9gxew91	195	5	of	of	IN
cord-015910-d9gxew91	195	6	a	a	DT
cord-015910-d9gxew91	195	7	group	group	NN
cord-015910-d9gxew91	195	8	of	of	IN
cord-015910-d9gxew91	195	9	826	826	CD
cord-015910-d9gxew91	195	10	40to	40to	CD
cord-015910-d9gxew91	195	11	79-yr	79-yr	CD
cord-015910-d9gxew91	195	12	-	-	HYPH
cord-015910-d9gxew91	195	13	old	old	JJ
cord-015910-d9gxew91	195	14	Italians	Italians	NNPS
cord-015910-d9gxew91	195	15	,	,	,
cord-015910-d9gxew91	195	16	it	-PRON-	PRP
cord-015910-d9gxew91	195	17	was	be	VBD
cord-015910-d9gxew91	195	18	found	find	VBN
cord-015910-d9gxew91	195	19	that	that	IN
cord-015910-d9gxew91	195	20	impaired	impair	VBN
cord-015910-d9gxew91	195	21	glucose	glucose	NN
cord-015910-d9gxew91	195	22	tolerance	tolerance	NN
cord-015910-d9gxew91	195	23	and	and	CC
cord-015910-d9gxew91	195	24	,	,	,
cord-015910-d9gxew91	195	25	to	to	IN
cord-015910-d9gxew91	195	26	a	a	DT
cord-015910-d9gxew91	195	27	greater	great	JJR
cord-015910-d9gxew91	195	28	extent	extent	NN
cord-015910-d9gxew91	195	29	,	,	,
cord-015910-d9gxew91	195	30	type	type	NN
cord-015910-d9gxew91	195	31	2	2	CD
cord-015910-d9gxew91	195	32	diabetes	diabete	NNS
cord-015910-d9gxew91	195	33	were	be	VBD
cord-015910-d9gxew91	195	34	strong	strong	JJ
cord-015910-d9gxew91	195	35	independent	independent	JJ
cord-015910-d9gxew91	195	36	predictors	predictor	NNS
cord-015910-d9gxew91	195	37	of	of	IN
cord-015910-d9gxew91	195	38	advanced	advanced	JJ
cord-015910-d9gxew91	195	39	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	195	40	(	(	-LRB-
cord-015910-d9gxew91	195	41	measured	measure	VBN
cord-015910-d9gxew91	195	42	by	by	IN
cord-015910-d9gxew91	195	43	high	high	JJ
cord-015910-d9gxew91	195	44	-	-	HYPH
cord-015910-d9gxew91	195	45	resolution	resolution	NN
cord-015910-d9gxew91	195	46	ultrasound	ultrasound	NN
cord-015910-d9gxew91	195	47	of	of	IN
cord-015910-d9gxew91	195	48	the	the	DT
cord-015910-d9gxew91	195	49	carotid	carotid	JJ
cord-015910-d9gxew91	195	50	artery	artery	NN
cord-015910-d9gxew91	195	51	)	)	-RRB-
cord-015910-d9gxew91	196	1	(	(	-LRB-
cord-015910-d9gxew91	196	2	Bonora	Bonora	NNP
cord-015910-d9gxew91	196	3	,	,	,
cord-015910-d9gxew91	196	4	Kiechl	Kiechl	NNP
cord-015910-d9gxew91	196	5	,	,	,
cord-015910-d9gxew91	196	6	&	&	CC
cord-015910-d9gxew91	196	7	Oberhollenzer	Oberhollenzer	NNP
cord-015910-d9gxew91	196	8	,	,	,
cord-015910-d9gxew91	196	9	2000	2000	CD
cord-015910-d9gxew91	196	10	)	)	-RRB-
cord-015910-d9gxew91	196	11	.	.	.
cord-015910-d9gxew91	197	1	A	a	DT
cord-015910-d9gxew91	197	2	cross	cross	JJ
cord-015910-d9gxew91	197	3	-	-	JJ
cord-015910-d9gxew91	197	4	sectional	sectional	JJ
cord-015910-d9gxew91	197	5	study	study	NN
cord-015910-d9gxew91	197	6	of	of	IN
cord-015910-d9gxew91	197	7	obesity	obesity	NN
cord-015910-d9gxew91	197	8	,	,	,
cord-015910-d9gxew91	197	9	plasma	plasma	NN
cord-015910-d9gxew91	197	10	CRP	crp	NN
cord-015910-d9gxew91	197	11	,	,	,
cord-015910-d9gxew91	197	12	fibrinogen	fibrinogen	NN
cord-015910-d9gxew91	197	13	,	,	,
cord-015910-d9gxew91	197	14	and	and	CC
cord-015910-d9gxew91	197	15	carotid	carotid	JJ
cord-015910-d9gxew91	197	16	artery	artery	NN
cord-015910-d9gxew91	197	17	intima	intima	NN
cord-015910-d9gxew91	197	18	media	medium	NNS
cord-015910-d9gxew91	197	19	thickness	thickness	NN
cord-015910-d9gxew91	197	20	(	(	-LRB-
cord-015910-d9gxew91	197	21	an	an	DT
cord-015910-d9gxew91	197	22	index	index	NN
cord-015910-d9gxew91	197	23	of	of	IN
cord-015910-d9gxew91	197	24	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	197	25	)	)	-RRB-
cord-015910-d9gxew91	197	26	in	in	IN
cord-015910-d9gxew91	197	27	more	more	JJR
cord-015910-d9gxew91	197	28	than	than	IN
cord-015910-d9gxew91	197	29	1500	1500	CD
cord-015910-d9gxew91	197	30	multiethnic	multiethnic	JJ
cord-015910-d9gxew91	197	31	subjects	subject	NNS
cord-015910-d9gxew91	197	32	showed	show	VBD
cord-015910-d9gxew91	197	33	a	a	DT
cord-015910-d9gxew91	197	34	positive	positive	JJ
cord-015910-d9gxew91	197	35	relationship	relationship	NN
cord-015910-d9gxew91	197	36	between	between	IN
cord-015910-d9gxew91	197	37	plasma	plasma	NN
cord-015910-d9gxew91	197	38	CRP	crp	NN
cord-015910-d9gxew91	197	39	and	and	CC
cord-015910-d9gxew91	197	40	body	body	NN
cord-015910-d9gxew91	197	41	fat	fat	NN
cord-015910-d9gxew91	197	42	.	.	.
cord-015910-d9gxew91	198	1	Intima	Intima	NNP
cord-015910-d9gxew91	198	2	media	medium	NNS
cord-015910-d9gxew91	198	3	thickness	thickness	NN
cord-015910-d9gxew91	198	4	was	be	VBD
cord-015910-d9gxew91	198	5	related	relate	VBN
cord-015910-d9gxew91	198	6	to	to	IN
cord-015910-d9gxew91	198	7	CRP	crp	NN
cord-015910-d9gxew91	198	8	and	and	CC
cord-015910-d9gxew91	198	9	fibrinogen	fibrinogen	NN
cord-015910-d9gxew91	198	10	in	in	IN
cord-015910-d9gxew91	198	11	men	man	NNS
cord-015910-d9gxew91	198	12	.	.	.
cord-015910-d9gxew91	199	1	The	the	DT
cord-015910-d9gxew91	199	2	relationship	relationship	NN
cord-015910-d9gxew91	199	3	was	be	VBD
cord-015910-d9gxew91	199	4	attenuated	attenuate	VBN
cord-015910-d9gxew91	199	5	by	by	IN
cord-015910-d9gxew91	199	6	adjustment	adjustment	NN
cord-015910-d9gxew91	199	7	for	for	IN
cord-015910-d9gxew91	199	8	BMI	BMI	NNP
cord-015910-d9gxew91	199	9	(	(	-LRB-
cord-015910-d9gxew91	199	10	Festa	Festa	NNP
cord-015910-d9gxew91	199	11	,	,	,
cord-015910-d9gxew91	199	12	D'Agostino	D'Agostino	NNP
cord-015910-d9gxew91	199	13	,	,	,
cord-015910-d9gxew91	199	14	&	&	CC
cord-015910-d9gxew91	199	15	Williams	Williams	NNP
cord-015910-d9gxew91	199	16	,	,	,
cord-015910-d9gxew91	199	17	2001	2001	CD
cord-015910-d9gxew91	199	18	)	)	-RRB-
cord-015910-d9gxew91	199	19	.	.	.
cord-015910-d9gxew91	200	1	A	a	DT
cord-015910-d9gxew91	200	2	cross	cross	JJ
cord-015910-d9gxew91	200	3	-	-	JJ
cord-015910-d9gxew91	200	4	sectional	sectional	JJ
cord-015910-d9gxew91	200	5	study	study	NN
cord-015910-d9gxew91	200	6	of	of	IN
cord-015910-d9gxew91	200	7	more	more	JJR
cord-015910-d9gxew91	200	8	than	than	IN
cord-015910-d9gxew91	200	9	1800	1800	CD
cord-015910-d9gxew91	200	10	men	man	NNS
cord-015910-d9gxew91	200	11	and	and	CC
cord-015910-d9gxew91	200	12	women	woman	NNS
cord-015910-d9gxew91	200	13	examined	examine	VBD
cord-015910-d9gxew91	200	14	the	the	DT
cord-015910-d9gxew91	200	15	link	link	NN
cord-015910-d9gxew91	200	16	between	between	IN
cord-015910-d9gxew91	200	17	elevated	elevated	JJ
cord-015910-d9gxew91	200	18	plasma	plasma	NN
cord-015910-d9gxew91	200	19	CRP	crp	NN
cord-015910-d9gxew91	200	20	concentrations	concentration	NNS
cord-015910-d9gxew91	200	21	and	and	CC
cord-015910-d9gxew91	200	22	prevalent	prevalent	JJ
cord-015910-d9gxew91	200	23	CVD	CVD	NNP
cord-015910-d9gxew91	200	24	,	,	,
cord-015910-d9gxew91	200	25	ankle	ankle	NN
cord-015910-d9gxew91	200	26	/	/	SYM
cord-015910-d9gxew91	200	27	brachial	brachial	JJ
cord-015910-d9gxew91	200	28	blood	blood	NN
cord-015910-d9gxew91	200	29	pressure	pressure	NN
cord-015910-d9gxew91	200	30	,	,	,
cord-015910-d9gxew91	200	31	and	and	CC
cord-015910-d9gxew91	200	32	carotid	carotid	JJ
cord-015910-d9gxew91	200	33	artery	artery	NN
cord-015910-d9gxew91	200	34	intima	intima	NN
cord-015910-d9gxew91	200	35	media	medium	NNS
cord-015910-d9gxew91	200	36	thickness	thickness	NN
cord-015910-d9gxew91	200	37	.	.	.
cord-015910-d9gxew91	201	1	After	after	IN
cord-015910-d9gxew91	201	2	adjustment	adjustment	NN
cord-015910-d9gxew91	201	3	for	for	IN
cord-015910-d9gxew91	201	4	age	age	NN
cord-015910-d9gxew91	201	5	and	and	CC
cord-015910-d9gxew91	201	6	family	family	NN
cord-015910-d9gxew91	201	7	type	type	NN
cord-015910-d9gxew91	201	8	,	,	,
cord-015910-d9gxew91	201	9	there	there	EX
cord-015910-d9gxew91	201	10	was	be	VBD
cord-015910-d9gxew91	201	11	a	a	DT
cord-015910-d9gxew91	201	12	weak	weak	JJ
cord-015910-d9gxew91	201	13	association	association	NN
cord-015910-d9gxew91	201	14	between	between	IN
cord-015910-d9gxew91	201	15	CRP	CRP	NNP
cord-015910-d9gxew91	201	16	and	and	CC
cord-015910-d9gxew91	201	17	intima	intima	NN
cord-015910-d9gxew91	201	18	media	medium	NNS
cord-015910-d9gxew91	201	19	thickness	thickness	NN
cord-015910-d9gxew91	201	20	in	in	IN
cord-015910-d9gxew91	201	21	both	both	DT
cord-015910-d9gxew91	201	22	sexes	sex	NNS
cord-015910-d9gxew91	201	23	and	and	CC
cord-015910-d9gxew91	201	24	with	with	IN
cord-015910-d9gxew91	201	25	prevalent	prevalent	JJ
cord-015910-d9gxew91	201	26	heart	heart	NN
cord-015910-d9gxew91	201	27	disease	disease	NN
cord-015910-d9gxew91	201	28	in	in	IN
cord-015910-d9gxew91	201	29	women	woman	NNS
cord-015910-d9gxew91	201	30	(	(	-LRB-
cord-015910-d9gxew91	201	31	Folsom	Folsom	NNP
cord-015910-d9gxew91	201	32	,	,	,
cord-015910-d9gxew91	201	33	Pankow	Pankow	NNP
cord-015910-d9gxew91	201	34	,	,	,
cord-015910-d9gxew91	201	35	&	&	CC
cord-015910-d9gxew91	201	36	Tracy	Tracy	NNP
cord-015910-d9gxew91	201	37	,	,	,
cord-015910-d9gxew91	201	38	2001	2001	CD
cord-015910-d9gxew91	201	39	)	)	-RRB-
cord-015910-d9gxew91	201	40	.	.	.
cord-015910-d9gxew91	202	1	A	a	DT
cord-015910-d9gxew91	202	2	study	study	NN
cord-015910-d9gxew91	202	3	on	on	IN
cord-015910-d9gxew91	202	4	a	a	DT
cord-015910-d9gxew91	202	5	Turkish	turkish	JJ
cord-015910-d9gxew91	202	6	population	population	NN
cord-015910-d9gxew91	202	7	of	of	IN
cord-015910-d9gxew91	202	8	1046	1046	CD
cord-015910-d9gxew91	202	9	individuals	individual	NNS
cord-015910-d9gxew91	202	10	with	with	IN
cord-015910-d9gxew91	202	11	low	low	JJ
cord-015910-d9gxew91	202	12	cholesterol	cholesterol	NN
cord-015910-d9gxew91	202	13	concentration	concentration	NN
cord-015910-d9gxew91	202	14	but	but	CC
cord-015910-d9gxew91	202	15	a	a	DT
cord-015910-d9gxew91	202	16	high	high	JJ
cord-015910-d9gxew91	202	17	prevalence	prevalence	NN
cord-015910-d9gxew91	202	18	of	of	IN
cord-015910-d9gxew91	202	19	other	other	JJ
cord-015910-d9gxew91	202	20	risk	risk	NN
cord-015910-d9gxew91	202	21	factors	factor	NNS
cord-015910-d9gxew91	202	22	for	for	IN
cord-015910-d9gxew91	202	23	coronary	coronary	JJ
cord-015910-d9gxew91	202	24	heart	heart	NN
cord-015910-d9gxew91	202	25	disease	disease	NN
cord-015910-d9gxew91	202	26	investigated	investigate	VBD
cord-015910-d9gxew91	202	27	whether	whether	IN
cord-015910-d9gxew91	202	28	CRP	CRP	NNP
cord-015910-d9gxew91	202	29	acted	act	VBD
cord-015910-d9gxew91	202	30	as	as	IN
cord-015910-d9gxew91	202	31	a	a	DT
cord-015910-d9gxew91	202	32	predictor	predictor	NN
cord-015910-d9gxew91	202	33	of	of	IN
cord-015910-d9gxew91	202	34	coronary	coronary	JJ
cord-015910-d9gxew91	202	35	heart	heart	NN
cord-015910-d9gxew91	202	36	disease	disease	NN
cord-015910-d9gxew91	202	37	.	.	.
cord-015910-d9gxew91	203	1	Among	among	IN
cord-015910-d9gxew91	203	2	the	the	DT
cord-015910-d9gxew91	203	3	risk	risk	NN
cord-015910-d9gxew91	203	4	factors	factor	NNS
cord-015910-d9gxew91	203	5	,	,	,
cord-015910-d9gxew91	203	6	only	only	RB
cord-015910-d9gxew91	203	7	CRP	CRP	NNP
cord-015910-d9gxew91	203	8	and	and	CC
cord-015910-d9gxew91	203	9	systolic	systolic	JJ
cord-015910-d9gxew91	203	10	blood	blood	NN
cord-015910-d9gxew91	203	11	pressure	pressure	NN
cord-015910-d9gxew91	203	12	were	be	VBD
cord-015910-d9gxew91	203	13	independent	independent	JJ
cord-015910-d9gxew91	203	14	risk	risk	NN
cord-015910-d9gxew91	203	15	factors	factor	NNS
cord-015910-d9gxew91	203	16	for	for	IN
cord-015910-d9gxew91	203	17	CVD	CVD	NNP
cord-015910-d9gxew91	203	18	(	(	-LRB-
cord-015910-d9gxew91	203	19	Onat	Onat	NNP
cord-015910-d9gxew91	203	20	,	,	,
cord-015910-d9gxew91	203	21	Sansoy	Sansoy	NNP
cord-015910-d9gxew91	203	22	,	,	,
cord-015910-d9gxew91	203	23	&	&	CC
cord-015910-d9gxew91	203	24	Yildirim	Yildirim	NNP
cord-015910-d9gxew91	203	25	,	,	,
cord-015910-d9gxew91	203	26	2001	2001	CD
cord-015910-d9gxew91	203	27	)	)	-RRB-
cord-015910-d9gxew91	203	28	.	.	.
cord-015910-d9gxew91	204	1	In	in	IN
cord-015910-d9gxew91	204	2	a	a	DT
cord-015910-d9gxew91	204	3	study	study	NN
cord-015910-d9gxew91	204	4	in	in	IN
cord-015910-d9gxew91	204	5	which	which	WDT
cord-015910-d9gxew91	204	6	CRP	crp	NN
cord-015910-d9gxew91	204	7	concentrations	concentration	NNS
cord-015910-d9gxew91	204	8	and	and	CC
cord-015910-d9gxew91	204	9	conventional	conventional	JJ
cord-015910-d9gxew91	204	10	risk	risk	NN
cord-015910-d9gxew91	204	11	factors	factor	NNS
cord-015910-d9gxew91	204	12	for	for	IN
cord-015910-d9gxew91	204	13	CVD	CVD	NNP
cord-015910-d9gxew91	204	14	in	in	IN
cord-015910-d9gxew91	204	15	500	500	CD
cord-015910-d9gxew91	204	16	healthy	healthy	JJ
cord-015910-d9gxew91	204	17	Indian	Indian	NNP
cord-015910-d9gxew91	204	18	Asians	Asians	NNPS
cord-015910-d9gxew91	204	19	were	be	VBD
cord-015910-d9gxew91	204	20	compared	compare	VBN
cord-015910-d9gxew91	204	21	with	with	IN
cord-015910-d9gxew91	204	22	values	value	NNS
cord-015910-d9gxew91	204	23	in	in	IN
cord-015910-d9gxew91	204	24	a	a	DT
cord-015910-d9gxew91	204	25	similar	similar	JJ
cord-015910-d9gxew91	204	26	number	number	NN
cord-015910-d9gxew91	204	27	of	of	IN
cord-015910-d9gxew91	204	28	healthy	healthy	JJ
cord-015910-d9gxew91	204	29	European	european	JJ
cord-015910-d9gxew91	204	30	white	white	JJ
cord-015910-d9gxew91	204	31	subjects	subject	NNS
cord-015910-d9gxew91	204	32	,	,	,
cord-015910-d9gxew91	204	33	CRP	CRP	NNP
cord-015910-d9gxew91	204	34	and	and	CC
cord-015910-d9gxew91	204	35	CVD	CVD	NNP
cord-015910-d9gxew91	204	36	risk	risk	NN
cord-015910-d9gxew91	204	37	factors	factor	NNS
cord-015910-d9gxew91	204	38	were	be	VBD
cord-015910-d9gxew91	204	39	higher	high	JJR
cord-015910-d9gxew91	204	40	in	in	IN
cord-015910-d9gxew91	204	41	the	the	DT
cord-015910-d9gxew91	204	42	former	former	JJ
cord-015910-d9gxew91	204	43	group	group	NN
cord-015910-d9gxew91	204	44	.	.	.
cord-015910-d9gxew91	205	1	However	however	RB
cord-015910-d9gxew91	205	2	,	,	,
cord-015910-d9gxew91	205	3	differences	difference	NNS
cord-015910-d9gxew91	205	4	were	be	VBD
cord-015910-d9gxew91	205	5	eliminated	eliminate	VBN
cord-015910-d9gxew91	205	6	when	when	WRB
cord-015910-d9gxew91	205	7	adjustment	adjustment	NN
cord-015910-d9gxew91	205	8	was	be	VBD
cord-015910-d9gxew91	205	9	made	make	VBN
cord-015910-d9gxew91	205	10	for	for	IN
cord-015910-d9gxew91	205	11	central	central	JJ
cord-015910-d9gxew91	205	12	obesity	obesity	NN
cord-015910-d9gxew91	205	13	and	and	CC
cord-015910-d9gxew91	205	14	insulin	insulin	NN
cord-015910-d9gxew91	205	15	resistance	resistance	NN
cord-015910-d9gxew91	205	16	score	score	NN
cord-015910-d9gxew91	205	17	(	(	-LRB-
cord-015910-d9gxew91	205	18	Chambers	Chambers	NNP
cord-015910-d9gxew91	205	19	,	,	,
cord-015910-d9gxew91	205	20	Eda	Eda	NNP
cord-015910-d9gxew91	205	21	,	,	,
cord-015910-d9gxew91	205	22	&	&	CC
cord-015910-d9gxew91	205	23	Bassett	Bassett	NNP
cord-015910-d9gxew91	205	24	,	,	,
cord-015910-d9gxew91	205	25	2001	2001	CD
cord-015910-d9gxew91	205	26	)	)	-RRB-
cord-015910-d9gxew91	205	27	.	.	.
cord-015910-d9gxew91	206	1	A	a	DT
cord-015910-d9gxew91	206	2	study	study	NN
cord-015910-d9gxew91	206	3	on	on	IN
cord-015910-d9gxew91	206	4	a	a	DT
cord-015910-d9gxew91	206	5	Brazilian	brazilian	JJ
cord-015910-d9gxew91	206	6	population	population	NN
cord-015910-d9gxew91	206	7	found	find	VBD
cord-015910-d9gxew91	206	8	that	that	IN
cord-015910-d9gxew91	206	9	markers	marker	NNS
cord-015910-d9gxew91	206	10	of	of	IN
cord-015910-d9gxew91	206	11	inflammation	inflammation	NN
cord-015910-d9gxew91	206	12	correlated	correlate	VBN
cord-015910-d9gxew91	206	13	with	with	IN
cord-015910-d9gxew91	206	14	components	component	NNS
cord-015910-d9gxew91	206	15	of	of	IN
cord-015910-d9gxew91	206	16	the	the	DT
cord-015910-d9gxew91	206	17	metabolic	metabolic	JJ
cord-015910-d9gxew91	206	18	syndrome	syndrome	NN
cord-015910-d9gxew91	206	19	---	---	:
cord-015910-d9gxew91	206	20	cardiovascular	cardiovascular	JJ
cord-015910-d9gxew91	206	21	and	and	CC
cord-015910-d9gxew91	206	22	diabetes	diabetes	NN
cord-015910-d9gxew91	206	23	risk	risk	NN
cord-015910-d9gxew91	206	24	factors	factor	NNS
cord-015910-d9gxew91	206	25	,	,	,
cord-015910-d9gxew91	206	26	insulin	insulin	NN
cord-015910-d9gxew91	206	27	resistance	resistance	NN
cord-015910-d9gxew91	206	28	,	,	,
cord-015910-d9gxew91	206	29	and	and	CC
cord-015910-d9gxew91	206	30	central	central	JJ
cord-015910-d9gxew91	206	31	obesity	obesity	NN
cord-015910-d9gxew91	206	32	(	(	-LRB-
cord-015910-d9gxew91	206	33	Duncan	Duncan	NNP
cord-015910-d9gxew91	206	34	&	&	CC
cord-015910-d9gxew91	206	35	Schmidt	Schmidt	NNP
cord-015910-d9gxew91	206	36	,	,	,
cord-015910-d9gxew91	206	37	2001	2001	CD
cord-015910-d9gxew91	206	38	)	)	-RRB-
cord-015910-d9gxew91	206	39	.	.	.
cord-015910-d9gxew91	207	1	In	in	IN
cord-015910-d9gxew91	207	2	a	a	DT
cord-015910-d9gxew91	207	3	study	study	NN
cord-015910-d9gxew91	207	4	of	of	IN
cord-015910-d9gxew91	207	5	574	574	CD
cord-015910-d9gxew91	207	6	healthy	healthy	JJ
cord-015910-d9gxew91	207	7	elderly	elderly	JJ
cord-015910-d9gxew91	207	8	subjects	subject	NNS
cord-015910-d9gxew91	207	9	in	in	IN
cord-015910-d9gxew91	207	10	the	the	DT
cord-015910-d9gxew91	207	11	Netherlands	Netherlands	NNP
cord-015910-d9gxew91	207	12	,	,	,
cord-015910-d9gxew91	207	13	acute	acute	JJ
cord-015910-d9gxew91	207	14	-	-	HYPH
cord-015910-d9gxew91	207	15	phase	phase	NN
cord-015910-d9gxew91	207	16	proteins	protein	NNS
cord-015910-d9gxew91	207	17	,	,	,
cord-015910-d9gxew91	207	18	soluble	soluble	JJ
cord-015910-d9gxew91	207	19	adhesion	adhesion	NN
cord-015910-d9gxew91	207	20	molecules	molecule	NNS
cord-015910-d9gxew91	207	21	,	,	,
cord-015910-d9gxew91	207	22	IL-6	IL-6	NNP
cord-015910-d9gxew91	207	23	,	,	,
cord-015910-d9gxew91	207	24	and	and	CC
cord-015910-d9gxew91	207	25	insulin	insulin	NN
cord-015910-d9gxew91	207	26	were	be	VBD
cord-015910-d9gxew91	207	27	measured	measure	VBN
cord-015910-d9gxew91	207	28	and	and	CC
cord-015910-d9gxew91	207	29	associated	associate	VBN
cord-015910-d9gxew91	207	30	with	with	IN
cord-015910-d9gxew91	207	31	cholesterol	cholesterol	NN
cord-015910-d9gxew91	207	32	and	and	CC
cord-015910-d9gxew91	207	33	obesity	obesity	NN
cord-015910-d9gxew91	207	34	.	.	.
cord-015910-d9gxew91	208	1	The	the	DT
cord-015910-d9gxew91	208	2	association	association	NN
cord-015910-d9gxew91	208	3	between	between	IN
cord-015910-d9gxew91	208	4	insulin	insulin	NN
cord-015910-d9gxew91	208	5	,	,	,
cord-015910-d9gxew91	208	6	obesity	obesity	NN
cord-015910-d9gxew91	208	7	,	,	,
cord-015910-d9gxew91	208	8	and	and	CC
cord-015910-d9gxew91	208	9	cholesterol	cholesterol	NN
cord-015910-d9gxew91	208	10	was	be	VBD
cord-015910-d9gxew91	208	11	as	as	RB
cord-015910-d9gxew91	208	12	strong	strong	JJ
cord-015910-d9gxew91	208	13	as	as	IN
cord-015910-d9gxew91	208	14	between	between	IN
cord-015910-d9gxew91	208	15	insulin	insulin	NN
cord-015910-d9gxew91	208	16	,	,	,
cord-015910-d9gxew91	208	17	acute	acute	JJ
cord-015910-d9gxew91	208	18	-	-	HYPH
cord-015910-d9gxew91	208	19	phase	phase	NN
cord-015910-d9gxew91	208	20	proteins	protein	NNS
cord-015910-d9gxew91	208	21	,	,	,
cord-015910-d9gxew91	208	22	and	and	CC
cord-015910-d9gxew91	208	23	adhesion	adhesion	NN
cord-015910-d9gxew91	208	24	molecules	molecule	NNS
cord-015910-d9gxew91	208	25	(	(	-LRB-
cord-015910-d9gxew91	208	26	Hak	Hak	NNP
cord-015910-d9gxew91	208	27	,	,	,
cord-015910-d9gxew91	208	28	Pols	Pols	NNPS
cord-015910-d9gxew91	208	29	,	,	,
cord-015910-d9gxew91	208	30	&	&	CC
cord-015910-d9gxew91	208	31	Stehouwer	Stehouwer	NNP
cord-015910-d9gxew91	208	32	,	,	,
cord-015910-d9gxew91	208	33	2001	2001	CD
cord-015910-d9gxew91	208	34	)	)	-RRB-
cord-015910-d9gxew91	208	35	.	.	.
cord-015910-d9gxew91	209	1	Insulin	insulin	NN
cord-015910-d9gxew91	209	2	insensitivity	insensitivity	NN
cord-015910-d9gxew91	209	3	occurs	occur	VBZ
cord-015910-d9gxew91	209	4	as	as	IN
cord-015910-d9gxew91	209	5	part	part	NN
cord-015910-d9gxew91	209	6	of	of	IN
cord-015910-d9gxew91	209	7	the	the	DT
cord-015910-d9gxew91	209	8	normal	normal	JJ
cord-015910-d9gxew91	209	9	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	209	10	response	response	NN
cord-015910-d9gxew91	209	11	to	to	IN
cord-015910-d9gxew91	209	12	pathogens	pathogen	NNS
cord-015910-d9gxew91	209	13	.	.	.
cord-015910-d9gxew91	210	1	During	during	IN
cord-015910-d9gxew91	210	2	inflammation	inflammation	NN
cord-015910-d9gxew91	210	3	the	the	DT
cord-015910-d9gxew91	210	4	secretion	secretion	NN
cord-015910-d9gxew91	210	5	of	of	IN
cord-015910-d9gxew91	210	6	catabolic	catabolic	JJ
cord-015910-d9gxew91	210	7	hormones	hormone	NNS
cord-015910-d9gxew91	210	8	,	,	,
cord-015910-d9gxew91	210	9	which	which	WDT
cord-015910-d9gxew91	210	10	enhances	enhance	VBZ
cord-015910-d9gxew91	210	11	muscle	muscle	NN
cord-015910-d9gxew91	210	12	protein	protein	NN
cord-015910-d9gxew91	210	13	breakdown	breakdown	NN
cord-015910-d9gxew91	210	14	and	and	CC
cord-015910-d9gxew91	210	15	glutamine	glutamine	NN
cord-015910-d9gxew91	210	16	release	release	NN
cord-015910-d9gxew91	210	17	,	,	,
cord-015910-d9gxew91	210	18	will	will	MD
cord-015910-d9gxew91	210	19	oppose	oppose	VB
cord-015910-d9gxew91	210	20	insulin	insulin	NN
cord-015910-d9gxew91	210	21	action	action	NN
cord-015910-d9gxew91	210	22	.	.	.
cord-015910-d9gxew91	211	1	Paradoxically	paradoxically	RB
cord-015910-d9gxew91	211	2	,	,	,
cord-015910-d9gxew91	211	3	however	however	RB
cord-015910-d9gxew91	211	4	,	,	,
cord-015910-d9gxew91	211	5	although	although	IN
cord-015910-d9gxew91	211	6	insulin	insulin	NN
cord-015910-d9gxew91	211	7	insensitivity	insensitivity	NN
cord-015910-d9gxew91	211	8	may	may	MD
cord-015910-d9gxew91	211	9	initially	initially	RB
cord-015910-d9gxew91	211	10	exert	exert	VB
cord-015910-d9gxew91	211	11	a	a	DT
cord-015910-d9gxew91	211	12	beneficial	beneficial	JJ
cord-015910-d9gxew91	211	13	effect	effect	NN
cord-015910-d9gxew91	211	14	during	during	IN
cord-015910-d9gxew91	211	15	the	the	DT
cord-015910-d9gxew91	211	16	response	response	NN
cord-015910-d9gxew91	211	17	to	to	IN
cord-015910-d9gxew91	211	18	infection	infection	NN
cord-015910-d9gxew91	211	19	and	and	CC
cord-015910-d9gxew91	211	20	injury	injury	NN
cord-015910-d9gxew91	211	21	,	,	,
cord-015910-d9gxew91	211	22	it	-PRON-	PRP
cord-015910-d9gxew91	211	23	has	have	VBZ
cord-015910-d9gxew91	211	24	an	an	DT
cord-015910-d9gxew91	211	25	adverse	adverse	JJ
cord-015910-d9gxew91	211	26	influence	influence	NN
cord-015910-d9gxew91	211	27	in	in	IN
cord-015910-d9gxew91	211	28	chronic	chronic	JJ
cord-015910-d9gxew91	211	29	disease	disease	NN
cord-015910-d9gxew91	211	30	processes	process	NNS
cord-015910-d9gxew91	211	31	.	.	.
cord-015910-d9gxew91	212	1	Glucose	glucose	NN
cord-015910-d9gxew91	212	2	and	and	CC
cord-015910-d9gxew91	212	3	glutamine	glutamine	NN
cord-015910-d9gxew91	212	4	act	act	NN
cord-015910-d9gxew91	212	5	as	as	IN
cord-015910-d9gxew91	212	6	major	major	JJ
cord-015910-d9gxew91	212	7	fuels	fuel	NNS
cord-015910-d9gxew91	212	8	for	for	IN
cord-015910-d9gxew91	212	9	immune	immune	JJ
cord-015910-d9gxew91	212	10	cells	cell	NNS
cord-015910-d9gxew91	212	11	during	during	IN
cord-015910-d9gxew91	212	12	the	the	DT
cord-015910-d9gxew91	212	13	normal	normal	JJ
cord-015910-d9gxew91	212	14	response	response	NN
cord-015910-d9gxew91	212	15	to	to	IN
cord-015910-d9gxew91	212	16	infection	infection	NN
cord-015910-d9gxew91	212	17	.	.	.
cord-015910-d9gxew91	213	1	Large	large	JJ
cord-015910-d9gxew91	213	2	increases	increase	NNS
cord-015910-d9gxew91	213	3	in	in	IN
cord-015910-d9gxew91	213	4	glucose	glucose	NN
cord-015910-d9gxew91	213	5	and	and	CC
cord-015910-d9gxew91	213	6	glutamine	glutamine	NN
cord-015910-d9gxew91	213	7	utilization	utilization	NN
cord-015910-d9gxew91	213	8	by	by	IN
cord-015910-d9gxew91	213	9	immune	immune	JJ
cord-015910-d9gxew91	213	10	cells	cell	NNS
cord-015910-d9gxew91	213	11	occur	occur	VBP
cord-015910-d9gxew91	213	12	during	during	IN
cord-015910-d9gxew91	213	13	the	the	DT
cord-015910-d9gxew91	213	14	response	response	NN
cord-015910-d9gxew91	213	15	to	to	IN
cord-015910-d9gxew91	213	16	infection	infection	NN
cord-015910-d9gxew91	213	17	and	and	CC
cord-015910-d9gxew91	213	18	injury	injury	NN
cord-015910-d9gxew91	213	19	(	(	-LRB-
cord-015910-d9gxew91	213	20	Spitzer	Spitzer	NNP
cord-015910-d9gxew91	213	21	,	,	,
cord-015910-d9gxew91	213	22	Bagby	Bagby	NNP
cord-015910-d9gxew91	213	23	,	,	,
cord-015910-d9gxew91	213	24	Meszaros	Meszaros	NNP
cord-015910-d9gxew91	213	25	,	,	,
cord-015910-d9gxew91	213	26	&	&	CC
cord-015910-d9gxew91	213	27	Lang	Lang	NNP
cord-015910-d9gxew91	213	28	,	,	,
cord-015910-d9gxew91	213	29	1988	1988	CD
cord-015910-d9gxew91	213	30	,	,	,
cord-015910-d9gxew91	213	31	1989	1989	CD
cord-015910-d9gxew91	213	32	.	.	.
cord-015910-d9gxew91	214	1	Studies	study	NNS
cord-015910-d9gxew91	214	2	in	in	IN
cord-015910-d9gxew91	214	3	rats	rat	NNS
cord-015910-d9gxew91	214	4	given	give	VBN
cord-015910-d9gxew91	214	5	LPS	lp	NNS
cord-015910-d9gxew91	214	6	and	and	CC
cord-015910-d9gxew91	214	7	observations	observation	NNS
cord-015910-d9gxew91	214	8	in	in	IN
cord-015910-d9gxew91	214	9	patients	patient	NNS
cord-015910-d9gxew91	214	10	with	with	IN
cord-015910-d9gxew91	214	11	sepsis	sepsis	NN
cord-015910-d9gxew91	214	12	show	show	VBP
cord-015910-d9gxew91	214	13	that	that	IN
cord-015910-d9gxew91	214	14	the	the	DT
cord-015910-d9gxew91	214	15	flow	flow	NN
cord-015910-d9gxew91	214	16	of	of	IN
cord-015910-d9gxew91	214	17	amino	amino	JJ
cord-015910-d9gxew91	214	18	acids	acid	NNS
cord-015910-d9gxew91	214	19	into	into	IN
cord-015910-d9gxew91	214	20	the	the	DT
cord-015910-d9gxew91	214	21	circulation	circulation	NN
cord-015910-d9gxew91	214	22	increases	increase	NNS
cord-015910-d9gxew91	214	23	and	and	CC
cord-015910-d9gxew91	214	24	gluconeogenesis	gluconeogenesis	NN
cord-015910-d9gxew91	214	25	is	be	VBZ
cord-015910-d9gxew91	214	26	enhanced	enhance	VBN
cord-015910-d9gxew91	214	27	under	under	IN
cord-015910-d9gxew91	214	28	the	the	DT
cord-015910-d9gxew91	214	29	influence	influence	NN
cord-015910-d9gxew91	214	30	of	of	IN
cord-015910-d9gxew91	214	31	pro	pro	JJ
cord-015910-d9gxew91	214	32	-	-	JJ
cord-015910-d9gxew91	214	33	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	214	34	cytokines	cytokine	NNS
cord-015910-d9gxew91	214	35	.	.	.
cord-015910-d9gxew91	215	1	An	an	DT
cord-015910-d9gxew91	215	2	insulin	insulin	NN
cord-015910-d9gxew91	215	3	-	-	HYPH
cord-015910-d9gxew91	215	4	insensitive	insensitive	JJ
cord-015910-d9gxew91	215	5	state	state	NN
cord-015910-d9gxew91	215	6	will	will	MD
cord-015910-d9gxew91	215	7	reduce	reduce	VB
cord-015910-d9gxew91	215	8	glucose	glucose	NN
cord-015910-d9gxew91	215	9	uptake	uptake	NN
cord-015910-d9gxew91	215	10	by	by	IN
cord-015910-d9gxew91	215	11	tissues	tissue	NNS
cord-015910-d9gxew91	215	12	in	in	IN
cord-015910-d9gxew91	215	13	which	which	WDT
cord-015910-d9gxew91	215	14	the	the	DT
cord-015910-d9gxew91	215	15	process	process	NN
cord-015910-d9gxew91	215	16	is	be	VBZ
cord-015910-d9gxew91	215	17	insulin	insulin	NN
cord-015910-d9gxew91	215	18	dependent	dependent	JJ
cord-015910-d9gxew91	215	19	(	(	-LRB-
cord-015910-d9gxew91	215	20	muscle	muscle	NN
cord-015910-d9gxew91	215	21	)	)	-RRB-
cord-015910-d9gxew91	215	22	,	,	,
cord-015910-d9gxew91	215	23	thereby	thereby	RB
cord-015910-d9gxew91	215	24	increasing	increase	VBG
cord-015910-d9gxew91	215	25	availability	availability	NN
cord-015910-d9gxew91	215	26	to	to	IN
cord-015910-d9gxew91	215	27	tissues	tissue	NNS
cord-015910-d9gxew91	215	28	in	in	IN
cord-015910-d9gxew91	215	29	which	which	WDT
cord-015910-d9gxew91	215	30	the	the	DT
cord-015910-d9gxew91	215	31	process	process	NN
cord-015910-d9gxew91	215	32	is	be	VBZ
cord-015910-d9gxew91	215	33	not	not	RB
cord-015910-d9gxew91	215	34	insulin	insulin	NN
cord-015910-d9gxew91	215	35	dependent	dependent	JJ
cord-015910-d9gxew91	215	36	(	(	-LRB-
cord-015910-d9gxew91	215	37	immune	immune	JJ
cord-015910-d9gxew91	215	38	tissue	tissue	NN
cord-015910-d9gxew91	215	39	)	)	-RRB-
cord-015910-d9gxew91	215	40	.	.	.
cord-015910-d9gxew91	216	1	A	a	DT
cord-015910-d9gxew91	216	2	study	study	NN
cord-015910-d9gxew91	216	3	in	in	IN
cord-015910-d9gxew91	216	4	the	the	DT
cord-015910-d9gxew91	216	5	United	United	NNP
cord-015910-d9gxew91	216	6	States	States	NNP
cord-015910-d9gxew91	216	7	investigated	investigate	VBD
cord-015910-d9gxew91	216	8	whether	whether	IN
cord-015910-d9gxew91	216	9	elevated	elevated	JJ
cord-015910-d9gxew91	216	10	plasma	plasma	NN
cord-015910-d9gxew91	216	11	IL-6	IL-6	NNP
cord-015910-d9gxew91	216	12	and	and	CC
cord-015910-d9gxew91	216	13	CRP	CRP	NNP
cord-015910-d9gxew91	216	14	was	be	VBD
cord-015910-d9gxew91	216	15	associated	associate	VBN
cord-015910-d9gxew91	216	16	with	with	IN
cord-015910-d9gxew91	216	17	the	the	DT
cord-015910-d9gxew91	216	18	development	development	NN
cord-015910-d9gxew91	216	19	of	of	IN
cord-015910-d9gxew91	216	20	type	type	NN
cord-015910-d9gxew91	216	21	2	2	CD
cord-015910-d9gxew91	216	22	diabetes	diabetes	NN
cord-015910-d9gxew91	216	23	mellitus	mellitus	NN
cord-015910-d9gxew91	216	24	in	in	IN
cord-015910-d9gxew91	216	25	more	more	JJR
cord-015910-d9gxew91	216	26	than	than	IN
cord-015910-d9gxew91	216	27	27,000	27,000	CD
cord-015910-d9gxew91	216	28	healthy	healthy	JJ
cord-015910-d9gxew91	216	29	women	woman	NNS
cord-015910-d9gxew91	216	30	.	.	.
cord-015910-d9gxew91	217	1	In	in	IN
cord-015910-d9gxew91	217	2	the	the	DT
cord-015910-d9gxew91	217	3	4-yr	4-yr	JJ
cord-015910-d9gxew91	217	4	follow	follow	NN
cord-015910-d9gxew91	217	5	-	-	HYPH
cord-015910-d9gxew91	217	6	up	up	NN
cord-015910-d9gxew91	217	7	period	period	NN
cord-015910-d9gxew91	217	8	,	,	,
cord-015910-d9gxew91	217	9	188	188	CD
cord-015910-d9gxew91	217	10	women	woman	NNS
cord-015910-d9gxew91	217	11	developed	develop	VBD
cord-015910-d9gxew91	217	12	type	type	NN
cord-015910-d9gxew91	217	13	2	2	CD
cord-015910-d9gxew91	217	14	diabetes	diabete	NNS
cord-015910-d9gxew91	217	15	.	.	.
cord-015910-d9gxew91	218	1	For	for	IN
cord-015910-d9gxew91	218	2	these	these	DT
cord-015910-d9gxew91	218	3	women	woman	NNS
cord-015910-d9gxew91	218	4	,	,	,
cord-015910-d9gxew91	218	5	baseline	baseline	JJ
cord-015910-d9gxew91	218	6	IL-6	IL-6	NNP
cord-015910-d9gxew91	218	7	and	and	CC
cord-015910-d9gxew91	218	8	CRP	CRP	NNP
cord-015910-d9gxew91	218	9	were	be	VBD
cord-015910-d9gxew91	218	10	higher	high	JJR
cord-015910-d9gxew91	218	11	than	than	IN
cord-015910-d9gxew91	218	12	in	in	IN
cord-015910-d9gxew91	218	13	controls	control	NNS
cord-015910-d9gxew91	218	14	.	.	.
cord-015910-d9gxew91	219	1	The	the	DT
cord-015910-d9gxew91	219	2	relative	relative	JJ
cord-015910-d9gxew91	219	3	risk	risk	NN
cord-015910-d9gxew91	219	4	of	of	IN
cord-015910-d9gxew91	219	5	future	future	JJ
cord-015910-d9gxew91	219	6	type	type	NN
cord-015910-d9gxew91	219	7	2	2	CD
cord-015910-d9gxew91	219	8	diabetes	diabete	NNS
cord-015910-d9gxew91	219	9	in	in	IN
cord-015910-d9gxew91	219	10	women	woman	NNS
cord-015910-d9gxew91	219	11	between	between	IN
cord-015910-d9gxew91	219	12	the	the	DT
cord-015910-d9gxew91	219	13	highest	high	JJS
cord-015910-d9gxew91	219	14	and	and	CC
cord-015910-d9gxew91	219	15	lowest	low	JJS
cord-015910-d9gxew91	219	16	quartiles	quartile	NNS
cord-015910-d9gxew91	219	17	of	of	IN
cord-015910-d9gxew91	219	18	these	these	DT
cord-015910-d9gxew91	219	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	219	20	markers	marker	NNS
cord-015910-d9gxew91	219	21	was	be	VBD
cord-015910-d9gxew91	219	22	7.5	7.5	CD
cord-015910-d9gxew91	219	23	for	for	IN
cord-015910-d9gxew91	219	24	IL-6	IL-6	NNP
cord-015910-d9gxew91	219	25	and	and	CC
cord-015910-d9gxew91	219	26	15.7	15.7	CD
cord-015910-d9gxew91	219	27	for	for	IN
cord-015910-d9gxew91	219	28	CRP	CRP	NNP
cord-015910-d9gxew91	219	29	(	(	-LRB-
cord-015910-d9gxew91	219	30	Pradhan	Pradhan	NNP
cord-015910-d9gxew91	219	31	,	,	,
cord-015910-d9gxew91	219	32	Manson	Manson	NNP
cord-015910-d9gxew91	219	33	,	,	,
cord-015910-d9gxew91	219	34	&	&	CC
cord-015910-d9gxew91	219	35	Rifai	Rifai	NNP
cord-015910-d9gxew91	219	36	,	,	,
cord-015910-d9gxew91	219	37	2001	2001	CD
cord-015910-d9gxew91	219	38	)	)	-RRB-
cord-015910-d9gxew91	220	1	These	these	DT
cord-015910-d9gxew91	220	2	data	datum	NNS
cord-015910-d9gxew91	220	3	suggest	suggest	VBP
cord-015910-d9gxew91	220	4	a	a	DT
cord-015910-d9gxew91	220	5	possible	possible	JJ
cord-015910-d9gxew91	220	6	role	role	NN
cord-015910-d9gxew91	220	7	for	for	IN
cord-015910-d9gxew91	220	8	inflammation	inflammation	NN
cord-015910-d9gxew91	220	9	in	in	IN
cord-015910-d9gxew91	220	10	diabetogenesis	diabetogenesis	NNP
cord-015910-d9gxew91	220	11	.	.	.
cord-015910-d9gxew91	221	1	Furthermore	furthermore	RB
cord-015910-d9gxew91	221	2	,	,	,
cord-015910-d9gxew91	221	3	data	datum	NNS
cord-015910-d9gxew91	221	4	collected	collect	VBN
cord-015910-d9gxew91	221	5	from	from	IN
cord-015910-d9gxew91	221	6	the	the	DT
cord-015910-d9gxew91	221	7	Third	Third	NNP
cord-015910-d9gxew91	221	8	National	National	NNP
cord-015910-d9gxew91	221	9	Health	Health	NNP
cord-015910-d9gxew91	221	10	and	and	CC
cord-015910-d9gxew91	221	11	Nutrition	Nutrition	NNP
cord-015910-d9gxew91	221	12	Examination	Examination	NNP
cord-015910-d9gxew91	221	13	Survey	Survey	NNP
cord-015910-d9gxew91	221	14	(	(	-LRB-
cord-015910-d9gxew91	221	15	NHANES	NHANES	NNP
cord-015910-d9gxew91	221	16	III	III	NNP
cord-015910-d9gxew91	221	17	)	)	-RRB-
cord-015910-d9gxew91	221	18	in	in	IN
cord-015910-d9gxew91	221	19	the	the	DT
cord-015910-d9gxew91	221	20	United	United	NNP
cord-015910-d9gxew91	221	21	States	States	NNP
cord-015910-d9gxew91	221	22	provide	provide	VBP
cord-015910-d9gxew91	221	23	further	further	JJ
cord-015910-d9gxew91	221	24	evidence	evidence	NN
cord-015910-d9gxew91	221	25	for	for	IN
cord-015910-d9gxew91	221	26	a	a	DT
cord-015910-d9gxew91	221	27	possible	possible	JJ
cord-015910-d9gxew91	221	28	role	role	NN
cord-015910-d9gxew91	221	29	of	of	IN
cord-015910-d9gxew91	221	30	inflammation	inflammation	NN
cord-015910-d9gxew91	221	31	in	in	IN
cord-015910-d9gxew91	221	32	insulin	insulin	NN
cord-015910-d9gxew91	221	33	resistance	resistance	NN
cord-015910-d9gxew91	221	34	and	and	CC
cord-015910-d9gxew91	221	35	glucose	glucose	NN
cord-015910-d9gxew91	221	36	intolerance	intolerance	NN
cord-015910-d9gxew91	221	37	.	.	.
cord-015910-d9gxew91	222	1	More	More	JJR
cord-015910-d9gxew91	222	2	than	than	IN
cord-015910-d9gxew91	222	3	2500	2500	CD
cord-015910-d9gxew91	222	4	men	man	NNS
cord-015910-d9gxew91	222	5	and	and	CC
cord-015910-d9gxew91	222	6	women	woman	NNS
cord-015910-d9gxew91	222	7	were	be	VBD
cord-015910-d9gxew91	222	8	studied	study	VBN
cord-015910-d9gxew91	222	9	for	for	IN
cord-015910-d9gxew91	222	10	associations	association	NNS
cord-015910-d9gxew91	222	11	between	between	IN
cord-015910-d9gxew91	222	12	plasma	plasma	NN
cord-015910-d9gxew91	222	13	CRP	crp	NN
cord-015910-d9gxew91	222	14	,	,	,
cord-015910-d9gxew91	222	15	fasting	fast	VBG
cord-015910-d9gxew91	222	16	insulin	insulin	NN
cord-015910-d9gxew91	222	17	,	,	,
cord-015910-d9gxew91	222	18	glucose	glucose	NN
cord-015910-d9gxew91	222	19	,	,	,
cord-015910-d9gxew91	222	20	and	and	CC
cord-015910-d9gxew91	222	21	glycosylated	glycosylated	JJ
cord-015910-d9gxew91	222	22	hemoglobin	hemoglobin	NN
cord-015910-d9gxew91	222	23	(	(	-LRB-
cord-015910-d9gxew91	222	24	HbA	HbA	NNP
cord-015910-d9gxew91	222	25	1	1	CD
cord-015910-d9gxew91	222	26	c	c	NN
cord-015910-d9gxew91	222	27	)	)	-RRB-
cord-015910-d9gxew91	222	28	.	.	.
cord-015910-d9gxew91	223	1	Elevated	elevated	JJ
cord-015910-d9gxew91	223	2	CRP	CRP	NNP
cord-015910-d9gxew91	223	3	was	be	VBD
cord-015910-d9gxew91	223	4	associated	associate	VBN
cord-015910-d9gxew91	223	5	with	with	IN
cord-015910-d9gxew91	223	6	higher	high	JJR
cord-015910-d9gxew91	223	7	insulin	insulin	NN
cord-015910-d9gxew91	223	8	and	and	CC
cord-015910-d9gxew91	223	9	HbA	hba	NN
cord-015910-d9gxew91	223	10	1	1	CD
cord-015910-d9gxew91	223	11	c	c	NN
cord-015910-d9gxew91	223	12	in	in	IN
cord-015910-d9gxew91	223	13	both	both	DT
cord-015910-d9gxew91	223	14	sexes	sex	NNS
cord-015910-d9gxew91	223	15	and	and	CC
cord-015910-d9gxew91	223	16	with	with	IN
cord-015910-d9gxew91	223	17	raised	raise	VBN
cord-015910-d9gxew91	223	18	glucose	glucose	NN
cord-015910-d9gxew91	223	19	in	in	IN
cord-015910-d9gxew91	223	20	women	woman	NNS
cord-015910-d9gxew91	223	21	(	(	-LRB-
cord-015910-d9gxew91	223	22	Wu	Wu	NNP
cord-015910-d9gxew91	223	23	,	,	,
cord-015910-d9gxew91	223	24	Dorn	Dorn	NNP
cord-015910-d9gxew91	223	25	,	,	,
cord-015910-d9gxew91	223	26	&	&	CC
cord-015910-d9gxew91	223	27	Donahue	Donahue	NNP
cord-015910-d9gxew91	223	28	,	,	,
cord-015910-d9gxew91	223	29	2002	2002	CD
cord-015910-d9gxew91	223	30	)	)	-RRB-
cord-015910-d9gxew91	223	31	.	.	.
cord-015910-d9gxew91	224	1	A	a	DT
cord-015910-d9gxew91	224	2	study	study	NN
cord-015910-d9gxew91	224	3	on	on	IN
cord-015910-d9gxew91	224	4	the	the	DT
cord-015910-d9gxew91	224	5	link	link	NN
cord-015910-d9gxew91	224	6	between	between	IN
cord-015910-d9gxew91	224	7	CRP	CRP	NNP
cord-015910-d9gxew91	224	8	,	,	,
cord-015910-d9gxew91	224	9	central	central	JJ
cord-015910-d9gxew91	224	10	adiposity	adiposity	NN
cord-015910-d9gxew91	224	11	,	,	,
cord-015910-d9gxew91	224	12	and	and	CC
cord-015910-d9gxew91	224	13	fasting	fast	VBG
cord-015910-d9gxew91	224	14	glucose	glucose	NN
cord-015910-d9gxew91	224	15	and	and	CC
cord-015910-d9gxew91	224	16	insulin	insulin	NN
cord-015910-d9gxew91	224	17	in	in	IN
cord-015910-d9gxew91	224	18	more	more	JJR
cord-015910-d9gxew91	224	19	than	than	IN
cord-015910-d9gxew91	224	20	200	200	CD
cord-015910-d9gxew91	224	21	healthy	healthy	JJ
cord-015910-d9gxew91	224	22	Italian	italian	JJ
cord-015910-d9gxew91	224	23	women	woman	NNS
cord-015910-d9gxew91	224	24	showed	show	VBD
cord-015910-d9gxew91	224	25	an	an	DT
cord-015910-d9gxew91	224	26	independent	independent	JJ
cord-015910-d9gxew91	224	27	relationship	relationship	NN
cord-015910-d9gxew91	224	28	of	of	IN
cord-015910-d9gxew91	224	29	adiposity	adiposity	NN
cord-015910-d9gxew91	224	30	to	to	IN
cord-015910-d9gxew91	224	31	insulin	insulin	NN
cord-015910-d9gxew91	224	32	resistance	resistance	NN
cord-015910-d9gxew91	224	33	and	and	CC
cord-015910-d9gxew91	224	34	CRP	crp	NN
cord-015910-d9gxew91	224	35	concentrations	concentration	NNS
cord-015910-d9gxew91	224	36	(	(	-LRB-
cord-015910-d9gxew91	224	37	Pannacciulli	Pannacciulli	NNP
cord-015910-d9gxew91	224	38	,	,	,
cord-015910-d9gxew91	224	39	Cantatore	Cantatore	NNP
cord-015910-d9gxew91	224	40	,	,	,
cord-015910-d9gxew91	224	41	&	&	CC
cord-015910-d9gxew91	224	42	Minenna	Minenna	NNP
cord-015910-d9gxew91	224	43	,	,	,
cord-015910-d9gxew91	224	44	2001	2001	CD
cord-015910-d9gxew91	224	45	)	)	-RRB-
cord-015910-d9gxew91	224	46	.	.	.
cord-015910-d9gxew91	225	1	In	in	IN
cord-015910-d9gxew91	225	2	a	a	DT
cord-015910-d9gxew91	225	3	review	review	NN
cord-015910-d9gxew91	225	4	,	,	,
cord-015910-d9gxew91	225	5	Nishimura	Nishimura	NNP
cord-015910-d9gxew91	225	6	and	and	CC
cord-015910-d9gxew91	225	7	Murayama	Murayama	NNP
cord-015910-d9gxew91	225	8	(	(	-LRB-
cord-015910-d9gxew91	225	9	2001	2001	CD
cord-015910-d9gxew91	225	10	)	)	-RRB-
cord-015910-d9gxew91	225	11	discussed	discuss	VBD
cord-015910-d9gxew91	225	12	the	the	DT
cord-015910-d9gxew91	225	13	possibility	possibility	NN
cord-015910-d9gxew91	225	14	that	that	IN
cord-015910-d9gxew91	225	15	treatment	treatment	NN
cord-015910-d9gxew91	225	16	of	of	IN
cord-015910-d9gxew91	225	17	periodontal	periodontal	JJ
cord-015910-d9gxew91	225	18	infection	infection	NN
cord-015910-d9gxew91	225	19	may	may	MD
cord-015910-d9gxew91	225	20	improve	improve	VB
cord-015910-d9gxew91	225	21	insulin	insulin	NN
cord-015910-d9gxew91	225	22	sensitivity	sensitivity	NN
cord-015910-d9gxew91	225	23	.	.	.
cord-015910-d9gxew91	226	1	Their	-PRON-	PRP$
cord-015910-d9gxew91	226	2	conclusions	conclusion	NNS
cord-015910-d9gxew91	226	3	about	about	IN
cord-015910-d9gxew91	226	4	the	the	DT
cord-015910-d9gxew91	226	5	efficacious	efficacious	JJ
cord-015910-d9gxew91	226	6	effect	effect	NN
cord-015910-d9gxew91	226	7	of	of	IN
cord-015910-d9gxew91	226	8	an	an	DT
cord-015910-d9gxew91	226	9	anti	anti	JJ
cord-015910-d9gxew91	226	10	-	-	JJ
cord-015910-d9gxew91	226	11	infective	infective	JJ
cord-015910-d9gxew91	226	12	approach	approach	NN
cord-015910-d9gxew91	226	13	are	be	VBP
cord-015910-d9gxew91	226	14	supported	support	VBN
cord-015910-d9gxew91	226	15	by	by	IN
cord-015910-d9gxew91	226	16	a	a	DT
cord-015910-d9gxew91	226	17	study	study	NN
cord-015910-d9gxew91	226	18	in	in	IN
cord-015910-d9gxew91	226	19	which	which	WDT
cord-015910-d9gxew91	226	20	13	13	CD
cord-015910-d9gxew91	226	21	type	type	NN
cord-015910-d9gxew91	226	22	2	2	CD
cord-015910-d9gxew91	226	23	diabetic	diabetic	JJ
cord-015910-d9gxew91	226	24	patients	patient	NNS
cord-015910-d9gxew91	226	25	with	with	IN
cord-015910-d9gxew91	226	26	periodontal	periodontal	JJ
cord-015910-d9gxew91	226	27	disease	disease	NN
cord-015910-d9gxew91	226	28	were	be	VBD
cord-015910-d9gxew91	226	29	given	give	VBN
cord-015910-d9gxew91	226	30	antimicrobial	antimicrobial	JJ
cord-015910-d9gxew91	226	31	treatment	treatment	NN
cord-015910-d9gxew91	226	32	with	with	IN
cord-015910-d9gxew91	226	33	minocycline	minocycline	NNP
cord-015910-d9gxew91	226	34	.	.	.
cord-015910-d9gxew91	227	1	Blood	blood	NN
cord-015910-d9gxew91	227	2	TNF	TNF	NNP
cord-015910-d9gxew91	227	3	-	-	HYPH
cord-015910-d9gxew91	227	4	t~	t~	NNP
cord-015910-d9gxew91	227	5	concentrations	concentration	NNS
cord-015910-d9gxew91	227	6	and	and	CC
cord-015910-d9gxew91	227	7	glycosylated	glycosylated	JJ
cord-015910-d9gxew91	227	8	hemoglobin	hemoglobin	NN
cord-015910-d9gxew91	227	9	decreased	decrease	VBD
cord-015910-d9gxew91	227	10	(	(	-LRB-
cord-015910-d9gxew91	227	11	Iwamoto	Iwamoto	NNP
cord-015910-d9gxew91	227	12	,	,	,
cord-015910-d9gxew91	227	13	Nishimura	Nishimura	NNP
cord-015910-d9gxew91	227	14	,	,	,
cord-015910-d9gxew91	227	15	&	&	CC
cord-015910-d9gxew91	227	16	Nakagawa	Nakagawa	NNP
cord-015910-d9gxew91	227	17	,	,	,
cord-015910-d9gxew91	227	18	2001	2001	CD
cord-015910-d9gxew91	227	19	)	)	-RRB-
cord-015910-d9gxew91	227	20	.	.	.
cord-015910-d9gxew91	228	1	Conversely	conversely	RB
cord-015910-d9gxew91	228	2	,	,	,
cord-015910-d9gxew91	228	3	improvement	improvement	NN
cord-015910-d9gxew91	228	4	in	in	IN
cord-015910-d9gxew91	228	5	insulin	insulin	NN
cord-015910-d9gxew91	228	6	sensitivity	sensitivity	NN
cord-015910-d9gxew91	228	7	exerted	exert	VBD
cord-015910-d9gxew91	228	8	an	an	DT
cord-015910-d9gxew91	228	9	anti	anti	JJ
cord-015910-d9gxew91	228	10	-	-	JJ
cord-015910-d9gxew91	228	11	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	228	12	effect	effect	NN
cord-015910-d9gxew91	228	13	.	.	.
cord-015910-d9gxew91	229	1	A	a	DT
cord-015910-d9gxew91	229	2	group	group	NN
cord-015910-d9gxew91	229	3	of	of	IN
cord-015910-d9gxew91	229	4	18	18	CD
cord-015910-d9gxew91	229	5	hyperlipidemic	hyperlipidemic	NN
cord-015910-d9gxew91	229	6	patients	patient	NNS
cord-015910-d9gxew91	229	7	and	and	CC
cord-015910-d9gxew91	229	8	20	20	CD
cord-015910-d9gxew91	229	9	normolipidemic	normolipidemic	NNP
cord-015910-d9gxew91	229	10	controls	control	NNS
cord-015910-d9gxew91	229	11	who	who	WP
cord-015910-d9gxew91	229	12	were	be	VBD
cord-015910-d9gxew91	229	13	insulin	insulin	NN
cord-015910-d9gxew91	229	14	resistant	resistant	JJ
cord-015910-d9gxew91	229	15	and	and	CC
cord-015910-d9gxew91	229	16	hypertriglyceridemic	hypertriglyceridemic	JJ
cord-015910-d9gxew91	229	17	with	with	IN
cord-015910-d9gxew91	229	18	low	low	JJ
cord-015910-d9gxew91	229	19	HDL	HDL	NNP
cord-015910-d9gxew91	229	20	cholesterol	cholesterol	NN
cord-015910-d9gxew91	229	21	concentrations	concentration	NNS
cord-015910-d9gxew91	229	22	and	and	CC
cord-015910-d9gxew91	229	23	raised	raise	VBD
cord-015910-d9gxew91	229	24	TNF	TNF	NNP
cord-015910-d9gxew91	229	25	-	-	HYPH
cord-015910-d9gxew91	229	26	o~	o~	CD
cord-015910-d9gxew91	229	27	production	production	NN
cord-015910-d9gxew91	229	28	and	and	CC
cord-015910-d9gxew91	229	29	plasma	plasma	NN
cord-015910-d9gxew91	229	30	IL-6	IL-6	NNP
cord-015910-d9gxew91	229	31	and	and	CC
cord-015910-d9gxew91	229	32	fibrinogen	fibrinogen	NN
cord-015910-d9gxew91	229	33	concentrations	concentration	NNS
cord-015910-d9gxew91	229	34	were	be	VBD
cord-015910-d9gxew91	229	35	studied	study	VBN
cord-015910-d9gxew91	229	36	.	.	.
cord-015910-d9gxew91	230	1	All	all	DT
cord-015910-d9gxew91	230	2	subjects	subject	NNS
cord-015910-d9gxew91	230	3	were	be	VBD
cord-015910-d9gxew91	230	4	treated	treat	VBN
cord-015910-d9gxew91	230	5	with	with	IN
cord-015910-d9gxew91	230	6	the	the	DT
cord-015910-d9gxew91	230	7	lipid	lipid	NN
cord-015910-d9gxew91	230	8	-	-	HYPH
cord-015910-d9gxew91	230	9	lowering	lower	VBG
cord-015910-d9gxew91	230	10	drug	drug	NN
cord-015910-d9gxew91	230	11	bezafibrate	bezafibrate	NNP
cord-015910-d9gxew91	230	12	.	.	.
cord-015910-d9gxew91	231	1	The	the	DT
cord-015910-d9gxew91	231	2	drug	drug	NN
cord-015910-d9gxew91	231	3	normalized	normalize	VBD
cord-015910-d9gxew91	231	4	all	all	DT
cord-015910-d9gxew91	231	5	parameters	parameter	NNS
cord-015910-d9gxew91	231	6	.	.	.
cord-015910-d9gxew91	232	1	The	the	DT
cord-015910-d9gxew91	232	2	drug	drug	NN
cord-015910-d9gxew91	232	3	thus	thus	RB
cord-015910-d9gxew91	232	4	exerts	exert	VBZ
cord-015910-d9gxew91	232	5	an	an	DT
cord-015910-d9gxew91	232	6	anti	anti	JJ
cord-015910-d9gxew91	232	7	-	-	JJ
cord-015910-d9gxew91	232	8	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	232	9	effect	effect	NN
cord-015910-d9gxew91	232	10	associated	associate	VBN
cord-015910-d9gxew91	232	11	with	with	IN
cord-015910-d9gxew91	232	12	its	-PRON-	PRP$
cord-015910-d9gxew91	232	13	ability	ability	NN
cord-015910-d9gxew91	232	14	to	to	TO
cord-015910-d9gxew91	232	15	normalize	normalize	VB
cord-015910-d9gxew91	232	16	lipid	lipid	NN
cord-015910-d9gxew91	232	17	metabolism	metabolism	NN
cord-015910-d9gxew91	232	18	and	and	CC
cord-015910-d9gxew91	232	19	insulin	insulin	NN
cord-015910-d9gxew91	232	20	sensitivity	sensitivity	NN
cord-015910-d9gxew91	232	21	(	(	-LRB-
cord-015910-d9gxew91	232	22	Jonkers	Jonkers	NNP
cord-015910-d9gxew91	232	23	,	,	,
cord-015910-d9gxew91	232	24	Mohrschladt	Mohrschladt	NNP
cord-015910-d9gxew91	232	25	,	,	,
cord-015910-d9gxew91	232	26	&	&	CC
cord-015910-d9gxew91	232	27	Westendorp	Westendorp	NNP
cord-015910-d9gxew91	232	28	,	,	,
cord-015910-d9gxew91	232	29	2002	2002	CD
cord-015910-d9gxew91	232	30	)	)	-RRB-
cord-015910-d9gxew91	232	31	.	.	.
cord-015910-d9gxew91	233	1	In	in	IN
cord-015910-d9gxew91	233	2	an	an	DT
cord-015910-d9gxew91	233	3	in	in	FW
cord-015910-d9gxew91	233	4	vitro	vitro	FW
cord-015910-d9gxew91	233	5	study	study	NN
cord-015910-d9gxew91	233	6	on	on	IN
cord-015910-d9gxew91	233	7	a	a	DT
cord-015910-d9gxew91	233	8	lung	lung	NN
cord-015910-d9gxew91	233	9	epithelial	epithelial	JJ
cord-015910-d9gxew91	233	10	cell	cell	NN
cord-015910-d9gxew91	233	11	line	line	NN
cord-015910-d9gxew91	233	12	,	,	,
cord-015910-d9gxew91	233	13	the	the	DT
cord-015910-d9gxew91	233	14	oral	oral	JJ
cord-015910-d9gxew91	233	15	hypoglycemic	hypoglycemic	JJ
cord-015910-d9gxew91	233	16	agent	agent	NN
cord-015910-d9gxew91	233	17	thiazolidinedione	thiazolidinedione	NNP
cord-015910-d9gxew91	233	18	exerted	exert	VBD
cord-015910-d9gxew91	233	19	an	an	DT
cord-015910-d9gxew91	233	20	anti	anti	JJ
cord-015910-d9gxew91	233	21	-	-	JJ
cord-015910-d9gxew91	233	22	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	233	23	influence	influence	NN
cord-015910-d9gxew91	233	24	by	by	IN
cord-015910-d9gxew91	233	25	suppressing	suppress	VBG
cord-015910-d9gxew91	233	26	production	production	NN
cord-015910-d9gxew91	233	27	of	of	IN
cord-015910-d9gxew91	233	28	monocyte	monocyte	NNP
cord-015910-d9gxew91	233	29	chemoattractant	chemoattractant	NNP
cord-015910-d9gxew91	233	30	protein	protein	NN
cord-015910-d9gxew91	233	31	(	(	-LRB-
cord-015910-d9gxew91	233	32	MCP-1	MCP-1	NNP
cord-015910-d9gxew91	233	33	)	)	-RRB-
cord-015910-d9gxew91	234	1	(	(	-LRB-
cord-015910-d9gxew91	234	2	Momoi	Momoi	NNP
cord-015910-d9gxew91	234	3	,	,	,
cord-015910-d9gxew91	234	4	Murao	Murao	NNP
cord-015910-d9gxew91	234	5	,	,	,
cord-015910-d9gxew91	234	6	&	&	CC
cord-015910-d9gxew91	234	7	Imachi	Imachi	NNP
cord-015910-d9gxew91	234	8	,	,	,
cord-015910-d9gxew91	234	9	2001	2001	CD
cord-015910-d9gxew91	234	10	)	)	-RRB-
cord-015910-d9gxew91	234	11	.	.	.
cord-015910-d9gxew91	235	1	It	-PRON-	PRP
cord-015910-d9gxew91	235	2	can	can	MD
cord-015910-d9gxew91	235	3	be	be	VB
cord-015910-d9gxew91	235	4	concluded	conclude	VBN
cord-015910-d9gxew91	235	5	from	from	IN
cord-015910-d9gxew91	235	6	the	the	DT
cord-015910-d9gxew91	235	7	studies	study	NNS
cord-015910-d9gxew91	235	8	reported	report	VBN
cord-015910-d9gxew91	235	9	in	in	IN
cord-015910-d9gxew91	235	10	the	the	DT
cord-015910-d9gxew91	235	11	above	above	JJ
cord-015910-d9gxew91	235	12	sections	section	NNS
cord-015910-d9gxew91	235	13	that	that	WDT
cord-015910-d9gxew91	235	14	inflammation	inflammation	NN
cord-015910-d9gxew91	235	15	is	be	VBZ
cord-015910-d9gxew91	235	16	closely	closely	RB
cord-015910-d9gxew91	235	17	linked	link	VBN
cord-015910-d9gxew91	235	18	to	to	IN
cord-015910-d9gxew91	235	19	obesity	obesity	NN
cord-015910-d9gxew91	235	20	,	,	,
cord-015910-d9gxew91	235	21	CVD	CVD	NNP
cord-015910-d9gxew91	235	22	,	,	,
cord-015910-d9gxew91	235	23	insulin	insulin	NN
cord-015910-d9gxew91	235	24	insensitivity	insensitivity	NN
cord-015910-d9gxew91	235	25	,	,	,
cord-015910-d9gxew91	235	26	and	and	CC
cord-015910-d9gxew91	235	27	diabetes	diabetes	NN
cord-015910-d9gxew91	235	28	mellitus	mellitus	NN
cord-015910-d9gxew91	235	29	.	.	.
cord-015910-d9gxew91	236	1	Although	although	IN
cord-015910-d9gxew91	236	2	this	this	DT
cord-015910-d9gxew91	236	3	interaction	interaction	NN
cord-015910-d9gxew91	236	4	is	be	VBZ
cord-015910-d9gxew91	236	5	a	a	DT
cord-015910-d9gxew91	236	6	relatively	relatively	RB
cord-015910-d9gxew91	236	7	novel	novel	JJ
cord-015910-d9gxew91	236	8	concept	concept	NN
cord-015910-d9gxew91	236	9	,	,	,
cord-015910-d9gxew91	236	10	it	-PRON-	PRP
cord-015910-d9gxew91	236	11	has	have	VBZ
cord-015910-d9gxew91	236	12	been	be	VBN
cord-015910-d9gxew91	236	13	known	know	VBN
cord-015910-d9gxew91	236	14	for	for	IN
cord-015910-d9gxew91	236	15	many	many	JJ
cord-015910-d9gxew91	236	16	years	year	NNS
cord-015910-d9gxew91	236	17	that	that	IN
cord-015910-d9gxew91	236	18	these	these	DT
cord-015910-d9gxew91	236	19	diseases	disease	NNS
cord-015910-d9gxew91	236	20	are	be	VBP
cord-015910-d9gxew91	236	21	interlinked	interlink	VBN
cord-015910-d9gxew91	236	22	and	and	CC
cord-015910-d9gxew91	236	23	that	that	IN
cord-015910-d9gxew91	236	24	insulin	insulin	NN
cord-015910-d9gxew91	236	25	insensitivity	insensitivity	NN
cord-015910-d9gxew91	236	26	is	be	VBZ
cord-015910-d9gxew91	236	27	a	a	DT
cord-015910-d9gxew91	236	28	common	common	JJ
cord-015910-d9gxew91	236	29	factor	factor	NN
cord-015910-d9gxew91	236	30	in	in	IN
cord-015910-d9gxew91	236	31	their	-PRON-	PRP$
cord-015910-d9gxew91	236	32	pathology	pathology	NN
cord-015910-d9gxew91	236	33	.	.	.
cord-015910-d9gxew91	237	1	A	a	DT
cord-015910-d9gxew91	237	2	number	number	NN
cord-015910-d9gxew91	237	3	of	of	IN
cord-015910-d9gxew91	237	4	recent	recent	JJ
cord-015910-d9gxew91	237	5	studies	study	NNS
cord-015910-d9gxew91	237	6	have	have	VBP
cord-015910-d9gxew91	237	7	examined	examine	VBN
cord-015910-d9gxew91	237	8	the	the	DT
cord-015910-d9gxew91	237	9	mechanisms	mechanism	NNS
cord-015910-d9gxew91	237	10	underlying	underlie	VBG
cord-015910-d9gxew91	237	11	the	the	DT
cord-015910-d9gxew91	237	12	link	link	NN
cord-015910-d9gxew91	237	13	between	between	IN
cord-015910-d9gxew91	237	14	inflammation	inflammation	NN
cord-015910-d9gxew91	237	15	and	and	CC
cord-015910-d9gxew91	237	16	the	the	DT
cord-015910-d9gxew91	237	17	conditions	condition	NNS
cord-015910-d9gxew91	237	18	and	and	CC
cord-015910-d9gxew91	237	19	diseases	disease	NNS
cord-015910-d9gxew91	237	20	in	in	IN
cord-015910-d9gxew91	237	21	which	which	WDT
cord-015910-d9gxew91	237	22	insulin	insulin	NN
cord-015910-d9gxew91	237	23	insensitivity	insensitivity	NN
cord-015910-d9gxew91	237	24	plays	play	VBZ
cord-015910-d9gxew91	237	25	a	a	DT
cord-015910-d9gxew91	237	26	part	part	NN
cord-015910-d9gxew91	237	27	(	(	-LRB-
cord-015910-d9gxew91	237	28	Fig	Fig	NNP
cord-015910-d9gxew91	237	29	.	.	.
cord-015910-d9gxew91	237	30	3	3	CD
cord-015910-d9gxew91	237	31	)	)	-RRB-
cord-015910-d9gxew91	237	32	.	.	.
cord-015910-d9gxew91	238	1	A	a	DT
cord-015910-d9gxew91	238	2	difficult	difficult	JJ
cord-015910-d9gxew91	238	3	question	question	NN
cord-015910-d9gxew91	238	4	to	to	TO
cord-015910-d9gxew91	238	5	address	address	VB
cord-015910-d9gxew91	238	6	is	be	VBZ
cord-015910-d9gxew91	238	7	whether	whether	IN
cord-015910-d9gxew91	238	8	chronic	chronic	JJ
cord-015910-d9gxew91	238	9	inflammation	inflammation	NN
cord-015910-d9gxew91	238	10	leads	lead	VBZ
cord-015910-d9gxew91	238	11	to	to	IN
cord-015910-d9gxew91	238	12	a	a	DT
cord-015910-d9gxew91	238	13	condition	condition	NN
cord-015910-d9gxew91	238	14	of	of	IN
cord-015910-d9gxew91	238	15	insulin	insulin	NN
cord-015910-d9gxew91	238	16	insensitivity	insensitivity	NN
cord-015910-d9gxew91	238	17	and	and	CC
cord-015910-d9gxew91	238	18	associated	associated	JJ
cord-015910-d9gxew91	238	19	diseases	disease	NNS
cord-015910-d9gxew91	238	20	,	,	,
cord-015910-d9gxew91	238	21	or	or	CC
cord-015910-d9gxew91	238	22	whether	whether	IN
cord-015910-d9gxew91	238	23	insulin	insulin	NN
cord-015910-d9gxew91	238	24	insensitivity	insensitivity	NN
cord-015910-d9gxew91	238	25	,	,	,
cord-015910-d9gxew91	238	26	which	which	WDT
cord-015910-d9gxew91	238	27	is	be	VBZ
cord-015910-d9gxew91	238	28	associated	associate	VBN
cord-015910-d9gxew91	238	29	with	with	IN
cord-015910-d9gxew91	238	30	obesity	obesity	NN
cord-015910-d9gxew91	238	31	,	,	,
cord-015910-d9gxew91	238	32	diabetes	diabetes	NN
cord-015910-d9gxew91	238	33	,	,	,
cord-015910-d9gxew91	238	34	and	and	CC
cord-015910-d9gxew91	238	35	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	238	36	,	,	,
cord-015910-d9gxew91	238	37	brings	bring	VBZ
cord-015910-d9gxew91	238	38	about	about	RP
cord-015910-d9gxew91	238	39	a	a	DT
cord-015910-d9gxew91	238	40	condition	condition	NN
cord-015910-d9gxew91	238	41	of	of	IN
cord-015910-d9gxew91	238	42	chronic	chronic	JJ
cord-015910-d9gxew91	238	43	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	238	44	stress	stress	NN
cord-015910-d9gxew91	238	45	.	.	.
cord-015910-d9gxew91	239	1	Many	many	JJ
cord-015910-d9gxew91	239	2	studies	study	NNS
cord-015910-d9gxew91	239	3	suggest	suggest	VBP
cord-015910-d9gxew91	239	4	that	that	IN
cord-015910-d9gxew91	239	5	the	the	DT
cord-015910-d9gxew91	239	6	former	former	JJ
cord-015910-d9gxew91	239	7	is	be	VBZ
cord-015910-d9gxew91	239	8	more	more	RBR
cord-015910-d9gxew91	239	9	likely	likely	JJ
cord-015910-d9gxew91	239	10	to	to	TO
cord-015910-d9gxew91	239	11	be	be	VB
cord-015910-d9gxew91	239	12	the	the	DT
cord-015910-d9gxew91	239	13	case	case	NN
cord-015910-d9gxew91	239	14	.	.	.
cord-015910-d9gxew91	240	1	Reviews	review	NNS
cord-015910-d9gxew91	240	2	have	have	VBP
cord-015910-d9gxew91	240	3	highlighted	highlight	VBN
cord-015910-d9gxew91	240	4	the	the	DT
cord-015910-d9gxew91	240	5	risk	risk	NN
cord-015910-d9gxew91	240	6	of	of	IN
cord-015910-d9gxew91	240	7	inflammation	inflammation	NN
cord-015910-d9gxew91	240	8	and	and	CC
cord-015910-d9gxew91	240	9	infection	infection	NN
cord-015910-d9gxew91	240	10	of	of	IN
cord-015910-d9gxew91	240	11	atherosclerotic	atherosclerotic	JJ
cord-015910-d9gxew91	240	12	plaques	plaque	NNS
cord-015910-d9gxew91	240	13	associated	associate	VBN
cord-015910-d9gxew91	240	14	with	with	IN
cord-015910-d9gxew91	240	15	poor	poor	JJ
cord-015910-d9gxew91	240	16	diabetic	diabetic	JJ
cord-015910-d9gxew91	240	17	control	control	NN
cord-015910-d9gxew91	240	18	and	and	CC
cord-015910-d9gxew91	240	19	the	the	DT
cord-015910-d9gxew91	240	20	importance	importance	NN
cord-015910-d9gxew91	240	21	of	of	IN
cord-015910-d9gxew91	240	22	elevated	elevated	JJ
cord-015910-d9gxew91	240	23	nonesterified	nonesterified	JJ
cord-015910-d9gxew91	240	24	fatty	fatty	JJ
cord-015910-d9gxew91	240	25	acid	acid	NN
cord-015910-d9gxew91	240	26	concentrations	concentration	NNS
cord-015910-d9gxew91	240	27	,	,	,
cord-015910-d9gxew91	240	28	glucocorticoids	glucocorticoid	NNS
cord-015910-d9gxew91	240	29	,	,	,
cord-015910-d9gxew91	240	30	and	and	CC
cord-015910-d9gxew91	240	31	low	low	JJ
cord-015910-d9gxew91	240	32	-	-	HYPH
cord-015910-d9gxew91	240	33	grade	grade	NN
cord-015910-d9gxew91	240	34	inflammation	inflammation	NN
cord-015910-d9gxew91	240	35	as	as	IN
cord-015910-d9gxew91	240	36	causative	causative	JJ
cord-015910-d9gxew91	240	37	agents	agent	NNS
cord-015910-d9gxew91	240	38	in	in	IN
cord-015910-d9gxew91	240	39	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	240	40	and	and	CC
cord-015910-d9gxew91	240	41	insulin	insulin	NN
cord-015910-d9gxew91	240	42	insensitivity	insensitivity	NN
cord-015910-d9gxew91	240	43	(	(	-LRB-
cord-015910-d9gxew91	240	44	Bell	Bell	NNP
cord-015910-d9gxew91	240	45	,	,	,
cord-015910-d9gxew91	240	46	2000	2000	CD
cord-015910-d9gxew91	240	47	;	;	:
cord-015910-d9gxew91	241	1	Corry	Corry	NNP
cord-015910-d9gxew91	241	2	&	&	CC
cord-015910-d9gxew91	241	3	Tuck	Tuck	NNP
cord-015910-d9gxew91	241	4	,	,	,
cord-015910-d9gxew91	241	5	2001	2001	CD
cord-015910-d9gxew91	241	6	)	)	-RRB-
cord-015910-d9gxew91	241	7	.	.	.
cord-015910-d9gxew91	242	1	A	a	DT
cord-015910-d9gxew91	242	2	study	study	NN
cord-015910-d9gxew91	242	3	on	on	IN
cord-015910-d9gxew91	242	4	type	type	NN
cord-015910-d9gxew91	242	5	2	2	CD
cord-015910-d9gxew91	242	6	diabetes	diabetes	NN
cord-015910-d9gxew91	242	7	mellitus	mellitus	NN
cord-015910-d9gxew91	242	8	patients	patient	NNS
cord-015910-d9gxew91	242	9	determined	determine	VBD
cord-015910-d9gxew91	242	10	the	the	DT
cord-015910-d9gxew91	242	11	extent	extent	NN
cord-015910-d9gxew91	242	12	to	to	TO
cord-015910-d9gxew91	242	13	which	which	WDT
cord-015910-d9gxew91	242	14	PBMCs	PBMCs	NNP
cord-015910-d9gxew91	242	15	contributed	contribute	VBD
cord-015910-d9gxew91	242	16	to	to	IN
cord-015910-d9gxew91	242	17	oxidative	oxidative	JJ
cord-015910-d9gxew91	242	18	stress	stress	NN
cord-015910-d9gxew91	242	19	and	and	CC
cord-015910-d9gxew91	242	20	inflammation	inflammation	NN
cord-015910-d9gxew91	242	21	.	.	.
cord-015910-d9gxew91	243	1	A	a	DT
cord-015910-d9gxew91	243	2	linear	linear	JJ
cord-015910-d9gxew91	243	3	correlation	correlation	NN
cord-015910-d9gxew91	243	4	between	between	IN
cord-015910-d9gxew91	243	5	HbAlc	HbAlc	NNP
cord-015910-d9gxew91	243	6	and	and	CC
cord-015910-d9gxew91	243	7	superoxide	superoxide	NN
cord-015910-d9gxew91	243	8	release	release	NN
cord-015910-d9gxew91	243	9	was	be	VBD
cord-015910-d9gxew91	243	10	found	find	VBN
cord-015910-d9gxew91	243	11	.	.	.
cord-015910-d9gxew91	244	1	The	the	DT
cord-015910-d9gxew91	244	2	authors	author	NNS
cord-015910-d9gxew91	244	3	concluded	conclude	VBD
cord-015910-d9gxew91	244	4	that	that	IN
cord-015910-d9gxew91	244	5	type	type	NN
cord-015910-d9gxew91	244	6	2	2	CD
cord-015910-d9gxew91	244	7	diabetes	diabetes	NN
cord-015910-d9gxew91	244	8	mellitus	mellitus	NN
cord-015910-d9gxew91	244	9	is	be	VBZ
cord-015910-d9gxew91	244	10	accompanied	accompany	VBN
cord-015910-d9gxew91	244	11	by	by	IN
cord-015910-d9gxew91	244	12	priming	prime	VBG
cord-015910-d9gxew91	244	13	of	of	IN
cord-015910-d9gxew91	244	14	PBMCs	pbmc	NNS
cord-015910-d9gxew91	244	15	and	and	CC
cord-015910-d9gxew91	244	16	increased	increase	VBN
cord-015910-d9gxew91	244	17	self	self	NN
cord-015910-d9gxew91	244	18	-	-	HYPH
cord-015910-d9gxew91	244	19	necrosis	necrosis	NN
cord-015910-d9gxew91	244	20	.	.	.
cord-015910-d9gxew91	245	1	The	the	DT
cord-015910-d9gxew91	245	2	necrosis	necrosis	NN
cord-015910-d9gxew91	245	3	may	may	MD
cord-015910-d9gxew91	245	4	start	start	VB
cord-015910-d9gxew91	245	5	a	a	DT
cord-015910-d9gxew91	245	6	chain	chain	NN
cord-015910-d9gxew91	245	7	of	of	IN
cord-015910-d9gxew91	245	8	events	event	NNS
cord-015910-d9gxew91	245	9	that	that	WDT
cord-015910-d9gxew91	245	10	results	result	VBZ
cord-015910-d9gxew91	245	11	ultimately	ultimately	RB
cord-015910-d9gxew91	245	12	in	in	IN
cord-015910-d9gxew91	245	13	oxidant	oxidant	JJ
cord-015910-d9gxew91	245	14	stress	stress	NN
cord-015910-d9gxew91	245	15	and	and	CC
cord-015910-d9gxew91	245	16	endothelial	endothelial	JJ
cord-015910-d9gxew91	245	17	dysfunction	dysfunction	NN
cord-015910-d9gxew91	246	1	(	(	-LRB-
cord-015910-d9gxew91	246	2	Shurtz	Shurtz	NNP
cord-015910-d9gxew91	246	3	-	-	HYPH
cord-015910-d9gxew91	246	4	Swirski	Swirski	NNP
cord-015910-d9gxew91	246	5	,	,	,
cord-015910-d9gxew91	246	6	Sela	Sela	NNP
cord-015910-d9gxew91	246	7	,	,	,
cord-015910-d9gxew91	246	8	&	&	CC
cord-015910-d9gxew91	246	9	Herskovitis	Herskovitis	NNP
cord-015910-d9gxew91	246	10	,	,	,
cord-015910-d9gxew91	246	11	2001	2001	CD
cord-015910-d9gxew91	246	12	)	)	-RRB-
cord-015910-d9gxew91	246	13	.	.	.
cord-015910-d9gxew91	247	1	In	in	IN
cord-015910-d9gxew91	247	2	a	a	DT
cord-015910-d9gxew91	247	3	study	study	NN
cord-015910-d9gxew91	247	4	on	on	IN
cord-015910-d9gxew91	247	5	Pima	Pima	NNP
cord-015910-d9gxew91	247	6	Indians	Indians	NNPS
cord-015910-d9gxew91	247	7	,	,	,
cord-015910-d9gxew91	247	8	who	who	WP
cord-015910-d9gxew91	247	9	are	be	VBP
cord-015910-d9gxew91	247	10	characterized	characterize	VBN
cord-015910-d9gxew91	247	11	by	by	IN
cord-015910-d9gxew91	247	12	high	high	JJ
cord-015910-d9gxew91	247	13	incidence	incidence	NN
cord-015910-d9gxew91	247	14	of	of	IN
cord-015910-d9gxew91	247	15	obesity	obesity	NN
cord-015910-d9gxew91	247	16	and	and	CC
cord-015910-d9gxew91	247	17	insulin	insulin	NN
cord-015910-d9gxew91	247	18	resistance	resistance	NN
cord-015910-d9gxew91	247	19	but	but	CC
cord-015910-d9gxew91	247	20	not	not	RB
cord-015910-d9gxew91	247	21	atherosclerotic	atherosclerotic	JJ
cord-015910-d9gxew91	247	22	disease	disease	NN
cord-015910-d9gxew91	247	23	,	,	,
cord-015910-d9gxew91	247	24	CRP	CRP	NNP
cord-015910-d9gxew91	247	25	,	,	,
cord-015910-d9gxew91	247	26	ICAM-1	ICAM-1	NNP
cord-015910-d9gxew91	247	27	,	,	,
cord-015910-d9gxew91	247	28	and	and	CC
cord-015910-d9gxew91	247	29	secretory	secretory	JJ
cord-015910-d9gxew91	247	30	phospholipase	phospholipase	NN
cord-015910-d9gxew91	247	31	A2	A2	NNP
cord-015910-d9gxew91	247	32	are	be	VBP
cord-015910-d9gxew91	247	33	correlated	correlate	VBN
cord-015910-d9gxew91	247	34	with	with	IN
cord-015910-d9gxew91	247	35	body	body	NN
cord-015910-d9gxew91	247	36	fat	fat	NN
cord-015910-d9gxew91	247	37	but	but	CC
cord-015910-d9gxew91	247	38	not	not	RB
cord-015910-d9gxew91	247	39	E	e	NN
cord-015910-d9gxew91	247	40	-	-	NN
cord-015910-d9gxew91	247	41	selectin	selectin	NNP
cord-015910-d9gxew91	247	42	and	and	CC
cord-015910-d9gxew91	247	43	von	von	NNP
cord-015910-d9gxew91	247	44	Willebrand	Willebrand	NNP
cord-015910-d9gxew91	247	45	factor	factor	NN
cord-015910-d9gxew91	247	46	.	.	.
cord-015910-d9gxew91	248	1	In	in	IN
cord-015910-d9gxew91	248	2	addition	addition	NN
cord-015910-d9gxew91	248	3	to	to	IN
cord-015910-d9gxew91	248	4	showing	show	VBG
cord-015910-d9gxew91	248	5	that	that	IN
cord-015910-d9gxew91	248	6	markers	marker	NNS
cord-015910-d9gxew91	248	7	of	of	IN
cord-015910-d9gxew91	248	8	inflammation	inflammation	NN
cord-015910-d9gxew91	248	9	increase	increase	NN
cord-015910-d9gxew91	248	10	with	with	IN
cord-015910-d9gxew91	248	11	adiposity	adiposity	NN
cord-015910-d9gxew91	248	12	,	,	,
cord-015910-d9gxew91	248	13	the	the	DT
cord-015910-d9gxew91	248	14	study	study	NN
cord-015910-d9gxew91	248	15	showed	show	VBD
cord-015910-d9gxew91	248	16	that	that	IN
cord-015910-d9gxew91	248	17	markers	marker	NNS
cord-015910-d9gxew91	248	18	of	of	IN
cord-015910-d9gxew91	248	19	endothelial	endothelial	JJ
cord-015910-d9gxew91	248	20	dysfunction	dysfunction	NN
cord-015910-d9gxew91	248	21	increase	increase	NN
cord-015910-d9gxew91	248	22	in	in	IN
cord-015910-d9gxew91	248	23	proportion	proportion	NN
cord-015910-d9gxew91	248	24	to	to	IN
cord-015910-d9gxew91	248	25	insulin	insulin	NN
cord-015910-d9gxew91	248	26	resistance	resistance	NN
cord-015910-d9gxew91	248	27	and	and	CC
cord-015910-d9gxew91	248	28	inflammation	inflammation	NN
cord-015910-d9gxew91	248	29	(	(	-LRB-
cord-015910-d9gxew91	248	30	Weyer	Weyer	NNP
cord-015910-d9gxew91	248	31	,	,	,
cord-015910-d9gxew91	248	32	Yudkin	Yudkin	NNP
cord-015910-d9gxew91	248	33	,	,	,
cord-015910-d9gxew91	248	34	&	&	CC
cord-015910-d9gxew91	248	35	Stehouwer	Stehouwer	NNP
cord-015910-d9gxew91	248	36	,	,	,
cord-015910-d9gxew91	248	37	2002	2002	CD
cord-015910-d9gxew91	248	38	)	)	-RRB-
cord-015910-d9gxew91	248	39	.	.	.
cord-015910-d9gxew91	249	1	A	a	DT
cord-015910-d9gxew91	249	2	further	further	JJ
cord-015910-d9gxew91	249	3	study	study	NN
cord-015910-d9gxew91	249	4	on	on	IN
cord-015910-d9gxew91	249	5	Pima	Pima	NNP
cord-015910-d9gxew91	249	6	Indians	Indians	NNPS
cord-015910-d9gxew91	249	7	examined	examine	VBD
cord-015910-d9gxew91	249	8	whether	whether	IN
cord-015910-d9gxew91	249	9	a	a	DT
cord-015910-d9gxew91	249	10	raised	raise	VBN
cord-015910-d9gxew91	249	11	white	white	JJ
cord-015910-d9gxew91	249	12	blood	blood	NN
cord-015910-d9gxew91	249	13	cell	cell	NN
cord-015910-d9gxew91	249	14	count	count	NN
cord-015910-d9gxew91	249	15	predicted	predict	VBD
cord-015910-d9gxew91	249	16	a	a	DT
cord-015910-d9gxew91	249	17	worsening	worsening	NN
cord-015910-d9gxew91	249	18	of	of	IN
cord-015910-d9gxew91	249	19	insulin	insulin	NN
cord-015910-d9gxew91	249	20	action	action	NN
cord-015910-d9gxew91	249	21	,	,	,
cord-015910-d9gxew91	249	22	insulin	insulin	NN
cord-015910-d9gxew91	249	23	secretory	secretory	JJ
cord-015910-d9gxew91	249	24	function	function	NN
cord-015910-d9gxew91	249	25	,	,	,
cord-015910-d9gxew91	249	26	and	and	CC
cord-015910-d9gxew91	249	27	the	the	DT
cord-015910-d9gxew91	249	28	development	development	NN
cord-015910-d9gxew91	249	29	of	of	IN
cord-015910-d9gxew91	249	30	type	type	NN
cord-015910-d9gxew91	249	31	2	2	CD
cord-015910-d9gxew91	249	32	diabetes	diabete	NNS
cord-015910-d9gxew91	249	33	.	.	.
cord-015910-d9gxew91	250	1	A	a	DT
cord-015910-d9gxew91	250	2	high	high	JJ
cord-015910-d9gxew91	250	3	white	white	JJ
cord-015910-d9gxew91	250	4	blood	blood	NN
cord-015910-d9gxew91	250	5	cell	cell	NN
cord-015910-d9gxew91	250	6	count	count	NN
cord-015910-d9gxew91	250	7	predicted	predict	VBD
cord-015910-d9gxew91	250	8	the	the	DT
cord-015910-d9gxew91	250	9	development	development	NN
cord-015910-d9gxew91	250	10	of	of	IN
cord-015910-d9gxew91	250	11	diabetes	diabete	NNS
cord-015910-d9gxew91	250	12	with	with	IN
cord-015910-d9gxew91	250	13	a	a	DT
cord-015910-d9gxew91	250	14	relative	relative	JJ
cord-015910-d9gxew91	250	15	risk	risk	NN
cord-015910-d9gxew91	250	16	of	of	IN
cord-015910-d9gxew91	250	17	2.7	2.7	CD
cord-015910-d9gxew91	250	18	when	when	WRB
cord-015910-d9gxew91	250	19	adjusted	adjust	VBN
cord-015910-d9gxew91	250	20	for	for	IN
cord-015910-d9gxew91	250	21	age	age	NN
cord-015910-d9gxew91	250	22	and	and	CC
cord-015910-d9gxew91	250	23	sex	sex	NN
cord-015910-d9gxew91	250	24	(	(	-LRB-
cord-015910-d9gxew91	250	25	Vozarova	Vozarova	NNP
cord-015910-d9gxew91	250	26	,	,	,
cord-015910-d9gxew91	250	27	Weyer	Weyer	NNP
cord-015910-d9gxew91	250	28	,	,	,
cord-015910-d9gxew91	250	29	&	&	CC
cord-015910-d9gxew91	250	30	Lindsay	Lindsay	NNP
cord-015910-d9gxew91	250	31	,	,	,
cord-015910-d9gxew91	250	32	2002	2002	CD
cord-015910-d9gxew91	250	33	)	)	-RRB-
cord-015910-d9gxew91	250	34	.	.	.
cord-015910-d9gxew91	251	1	TNF	TNF	NNP
cord-015910-d9gxew91	251	2	-	-	HYPH
cord-015910-d9gxew91	251	3	o~	o~	NNP
cord-015910-d9gxew91	251	4	has	have	VBZ
cord-015910-d9gxew91	251	5	been	be	VBN
cord-015910-d9gxew91	251	6	shown	show	VBN
cord-015910-d9gxew91	251	7	to	to	TO
cord-015910-d9gxew91	251	8	play	play	VB
cord-015910-d9gxew91	251	9	a	a	DT
cord-015910-d9gxew91	251	10	key	key	JJ
cord-015910-d9gxew91	251	11	role	role	NN
cord-015910-d9gxew91	251	12	in	in	IN
cord-015910-d9gxew91	251	13	mediating	mediate	VBG
cord-015910-d9gxew91	251	14	insulin	insulin	NN
cord-015910-d9gxew91	251	15	resistance	resistance	NN
cord-015910-d9gxew91	251	16	as	as	IN
cord-015910-d9gxew91	251	17	a	a	DT
cord-015910-d9gxew91	251	18	result	result	NN
cord-015910-d9gxew91	251	19	of	of	IN
cord-015910-d9gxew91	251	20	obesity	obesity	NN
cord-015910-d9gxew91	251	21	in	in	IN
cord-015910-d9gxew91	251	22	patients	patient	NNS
cord-015910-d9gxew91	251	23	and	and	CC
cord-015910-d9gxew91	251	24	in	in	IN
cord-015910-d9gxew91	251	25	numerous	numerous	JJ
cord-015910-d9gxew91	251	26	rodent	rodent	NN
cord-015910-d9gxew91	251	27	models	model	NNS
cord-015910-d9gxew91	251	28	of	of	IN
cord-015910-d9gxew91	251	29	obesity	obesity	NN
cord-015910-d9gxew91	251	30	---	---	:
cord-015910-d9gxew91	251	31	diabetes	diabetes	NN
cord-015910-d9gxew91	251	32	syndromes	syndrome	NNS
cord-015910-d9gxew91	251	33	(	(	-LRB-
cord-015910-d9gxew91	251	34	Hotamiligil	Hotamiligil	NNP
cord-015910-d9gxew91	251	35	&	&	CC
cord-015910-d9gxew91	251	36	Spiegelman	Spiegelman	NNP
cord-015910-d9gxew91	251	37	,	,	,
cord-015910-d9gxew91	251	38	1994	1994	CD
cord-015910-d9gxew91	251	39	)	)	-RRB-
cord-015910-d9gxew91	251	40	.	.	.
cord-015910-d9gxew91	252	1	Multiple	multiple	JJ
cord-015910-d9gxew91	252	2	mechanisms	mechanism	NNS
cord-015910-d9gxew91	252	3	have	have	VBP
cord-015910-d9gxew91	252	4	been	be	VBN
cord-015910-d9gxew91	252	5	suggested	suggest	VBN
cord-015910-d9gxew91	252	6	to	to	TO
cord-015910-d9gxew91	252	7	account	account	VB
cord-015910-d9gxew91	252	8	for	for	IN
cord-015910-d9gxew91	252	9	these	these	DT
cord-015910-d9gxew91	252	10	metabolic	metabolic	JJ
cord-015910-d9gxew91	252	11	effects	effect	NNS
cord-015910-d9gxew91	252	12	of	of	IN
cord-015910-d9gxew91	252	13	TNF	TNF	NNP
cord-015910-d9gxew91	252	14	-	-	HYPH
cord-015910-d9gxew91	252	15	ot	ot	NNP
cord-015910-d9gxew91	252	16	.	.	.
cord-015910-d9gxew91	253	1	These	these	DT
cord-015910-d9gxew91	253	2	include	include	VBP
cord-015910-d9gxew91	253	3	the	the	DT
cord-015910-d9gxew91	253	4	downregulation	downregulation	NN
cord-015910-d9gxew91	253	5	of	of	IN
cord-015910-d9gxew91	253	6	genes	gene	NNS
cord-015910-d9gxew91	253	7	that	that	WDT
cord-015910-d9gxew91	253	8	are	be	VBP
cord-015910-d9gxew91	253	9	required	require	VBN
cord-015910-d9gxew91	253	10	for	for	IN
cord-015910-d9gxew91	253	11	normal	normal	JJ
cord-015910-d9gxew91	253	12	insulin	insulin	NN
cord-015910-d9gxew91	253	13	action	action	NN
cord-015910-d9gxew91	253	14	,	,	,
cord-015910-d9gxew91	253	15	direct	direct	JJ
cord-015910-d9gxew91	253	16	effects	effect	NNS
cord-015910-d9gxew91	253	17	on	on	IN
cord-015910-d9gxew91	253	18	insulin	insulin	NN
cord-015910-d9gxew91	253	19	signaling	signaling	NN
cord-015910-d9gxew91	253	20	,	,	,
cord-015910-d9gxew91	253	21	induction	induction	NN
cord-015910-d9gxew91	253	22	of	of	IN
cord-015910-d9gxew91	253	23	elevated	elevated	JJ
cord-015910-d9gxew91	253	24	plasma	plasma	NN
cord-015910-d9gxew91	253	25	free	free	JJ
cord-015910-d9gxew91	253	26	fatty	fatty	JJ
cord-015910-d9gxew91	253	27	acids	acid	NNS
cord-015910-d9gxew91	253	28	via	via	IN
cord-015910-d9gxew91	253	29	stimulation	stimulation	NN
cord-015910-d9gxew91	253	30	of	of	IN
cord-015910-d9gxew91	253	31	lipolysis	lipolysis	NN
cord-015910-d9gxew91	253	32	,	,	,
cord-015910-d9gxew91	253	33	and	and	CC
cord-015910-d9gxew91	253	34	negative	negative	JJ
cord-015910-d9gxew91	253	35	regulation	regulation	NN
cord-015910-d9gxew91	253	36	of	of	IN
cord-015910-d9gxew91	253	37	PPAR-7	PPAR-7	NNP
cord-015910-d9gxew91	253	38	,	,	,
cord-015910-d9gxew91	253	39	an	an	DT
cord-015910-d9gxew91	253	40	important	important	JJ
cord-015910-d9gxew91	253	41	insulin	insulin	NN
cord-015910-d9gxew91	253	42	-	-	HYPH
cord-015910-d9gxew91	253	43	sensitizing	sensitize	VBG
cord-015910-d9gxew91	253	44	nuclear	nuclear	JJ
cord-015910-d9gxew91	253	45	receptor	receptor	NN
cord-015910-d9gxew91	253	46	(	(	-LRB-
cord-015910-d9gxew91	253	47	Moiler	Moiler	NNP
cord-015910-d9gxew91	253	48	,	,	,
cord-015910-d9gxew91	253	49	2000	2000	CD
cord-015910-d9gxew91	253	50	)	)	-RRB-
cord-015910-d9gxew91	253	51	.	.	.
cord-015910-d9gxew91	254	1	The	the	DT
cord-015910-d9gxew91	254	2	induction	induction	NN
cord-015910-d9gxew91	254	3	of	of	IN
cord-015910-d9gxew91	254	4	insulin	insulin	NN
cord-015910-d9gxew91	254	5	resistance	resistance	NN
cord-015910-d9gxew91	254	6	is	be	VBZ
cord-015910-d9gxew91	254	7	mediated	mediate	VBN
cord-015910-d9gxew91	254	8	through	through	IN
cord-015910-d9gxew91	254	9	its	-PRON-	PRP$
cord-015910-d9gxew91	254	10	ability	ability	NN
cord-015910-d9gxew91	254	11	to	to	TO
cord-015910-d9gxew91	254	12	produce	produce	VB
cord-015910-d9gxew91	254	13	serine	serine	NN
cord-015910-d9gxew91	254	14	phosphorylation	phosphorylation	NN
cord-015910-d9gxew91	254	15	of	of	IN
cord-015910-d9gxew91	254	16	insulin	insulin	NN
cord-015910-d9gxew91	254	17	receptor	receptor	NN
cord-015910-d9gxew91	254	18	substrate	substrate	NN
cord-015910-d9gxew91	254	19	(	(	-LRB-
cord-015910-d9gxew91	254	20	IRS)-1	irs)-1	NN
cord-015910-d9gxew91	254	21	,	,	,
cord-015910-d9gxew91	254	22	decreasing	decrease	VBG
cord-015910-d9gxew91	254	23	the	the	DT
cord-015910-d9gxew91	254	24	tyrosine	tyrosine	NN
cord-015910-d9gxew91	254	25	kinase	kinase	NN
cord-015910-d9gxew91	254	26	activity	activity	NN
cord-015910-d9gxew91	254	27	of	of	IN
cord-015910-d9gxew91	254	28	the	the	DT
cord-015910-d9gxew91	254	29	insulin	insulin	NN
cord-015910-d9gxew91	254	30	receptor	receptor	NN
cord-015910-d9gxew91	254	31	(	(	-LRB-
cord-015910-d9gxew91	254	32	Hotamisligil	Hotamisligil	NNP
cord-015910-d9gxew91	254	33	,	,	,
cord-015910-d9gxew91	254	34	Budavari	Budavari	NNP
cord-015910-d9gxew91	254	35	,	,	,
cord-015910-d9gxew91	254	36	Murray	Murray	NNP
cord-015910-d9gxew91	254	37	,	,	,
cord-015910-d9gxew91	254	38	&	&	CC
cord-015910-d9gxew91	254	39	Spiegelman	Spiegelman	NNP
cord-015910-d9gxew91	254	40	,	,	,
cord-015910-d9gxew91	254	41	1994	1994	CD
cord-015910-d9gxew91	254	42	)	)	-RRB-
cord-015910-d9gxew91	254	43	.	.	.
cord-015910-d9gxew91	255	1	Neutralization	neutralization	NN
cord-015910-d9gxew91	255	2	of	of	IN
cord-015910-d9gxew91	255	3	TNF	TNF	NNP
cord-015910-d9gxew91	255	4	-	-	HYPH
cord-015910-d9gxew91	255	5	t~	t~	NNP
cord-015910-d9gxew91	255	6	in	in	IN
cord-015910-d9gxew91	255	7	obese	obese	JJ
cord-015910-d9gxew91	255	8	fa	fa	NNP
cord-015910-d9gxew91	255	9	/	/	SYM
cord-015910-d9gxew91	255	10	fa	fa	NN
cord-015910-d9gxew91	255	11	rats	rat	NNS
cord-015910-d9gxew91	255	12	by	by	IN
cord-015910-d9gxew91	255	13	intravenous	intravenous	JJ
cord-015910-d9gxew91	255	14	administration	administration	NN
cord-015910-d9gxew91	255	15	of	of	IN
cord-015910-d9gxew91	255	16	a	a	DT
cord-015910-d9gxew91	255	17	soluble	soluble	JJ
cord-015910-d9gxew91	255	18	TNF	TNF	NNP
cord-015910-d9gxew91	255	19	receptor	receptor	NN
cord-015910-d9gxew91	255	20	immunoglobulin	immunoglobulin	NN
cord-015910-d9gxew91	255	21	G	g	NN
cord-015910-d9gxew91	255	22	chimeric	chimeric	JJ
cord-015910-d9gxew91	255	23	protein	protein	NN
cord-015910-d9gxew91	255	24	substantially	substantially	RB
cord-015910-d9gxew91	255	25	improved	improve	VBD
cord-015910-d9gxew91	255	26	insulin	insulin	NN
cord-015910-d9gxew91	255	27	sensitivity	sensitivity	NN
cord-015910-d9gxew91	255	28	and	and	CC
cord-015910-d9gxew91	255	29	restored	restore	VBD
cord-015910-d9gxew91	255	30	the	the	DT
cord-015910-d9gxew91	255	31	tyrosine	tyrosine	NN
cord-015910-d9gxew91	255	32	kinase	kinase	NN
cord-015910-d9gxew91	255	33	activity	activity	NN
cord-015910-d9gxew91	255	34	in	in	IN
cord-015910-d9gxew91	255	35	fat	fat	NN
cord-015910-d9gxew91	255	36	and	and	CC
cord-015910-d9gxew91	255	37	muscle	muscle	NN
cord-015910-d9gxew91	255	38	(	(	-LRB-
cord-015910-d9gxew91	255	39	Hotamisligil	Hotamisligil	NNP
cord-015910-d9gxew91	255	40	et	et	NNP
cord-015910-d9gxew91	255	41	al	al	NNP
cord-015910-d9gxew91	255	42	.	.	NNP
cord-015910-d9gxew91	255	43	,	,	,
cord-015910-d9gxew91	255	44	1996	1996	CD
cord-015910-d9gxew91	255	45	)	)	-RRB-
cord-015910-d9gxew91	255	46	.	.	.
cord-015910-d9gxew91	256	1	In	in	IN
cord-015910-d9gxew91	256	2	an	an	DT
cord-015910-d9gxew91	256	3	in	in	FW
cord-015910-d9gxew91	256	4	vitro	vitro	FW
cord-015910-d9gxew91	256	5	study	study	NN
cord-015910-d9gxew91	256	6	using	use	VBG
cord-015910-d9gxew91	256	7	3T3-L	3t3-l	CD
cord-015910-d9gxew91	256	8	1	1	CD
cord-015910-d9gxew91	256	9	adipocytes	adipocyte	NNS
cord-015910-d9gxew91	256	10	,	,	,
cord-015910-d9gxew91	256	11	TNF	TNF	NNP
cord-015910-d9gxew91	256	12	-	-	HYPH
cord-015910-d9gxew91	256	13	t~	t~	NNP
cord-015910-d9gxew91	256	14	was	be	VBD
cord-015910-d9gxew91	256	15	shown	show	VBN
cord-015910-d9gxew91	256	16	to	to	TO
cord-015910-d9gxew91	256	17	induce	induce	VB
cord-015910-d9gxew91	256	18	sustained	sustained	JJ
cord-015910-d9gxew91	256	19	suppressor	suppressor	NN
cord-015910-d9gxew91	256	20	of	of	IN
cord-015910-d9gxew91	256	21	cytokine	cytokine	NN
cord-015910-d9gxew91	256	22	signaling	signal	VBG
cord-015910-d9gxew91	256	23	protein	protein	NN
cord-015910-d9gxew91	256	24	3	3	CD
cord-015910-d9gxew91	256	25	(	(	-LRB-
cord-015910-d9gxew91	256	26	SOCS-3	SOCS-3	NNP
cord-015910-d9gxew91	256	27	)	)	-RRB-
cord-015910-d9gxew91	256	28	production	production	NN
cord-015910-d9gxew91	256	29	.	.	.
cord-015910-d9gxew91	257	1	SOCS-3	SOCS-3	NNP
cord-015910-d9gxew91	257	2	has	have	VBZ
cord-015910-d9gxew91	257	3	been	be	VBN
cord-015910-d9gxew91	257	4	shown	show	VBN
cord-015910-d9gxew91	257	5	to	to	TO
cord-015910-d9gxew91	257	6	decrease	decrease	VB
cord-015910-d9gxew91	257	7	insulin	insulin	NN
cord-015910-d9gxew91	257	8	-	-	HYPH
cord-015910-d9gxew91	257	9	induced	induce	VBN
cord-015910-d9gxew91	257	10	IRS	IRS	NNP
cord-015910-d9gxew91	257	11	1	1	CD
cord-015910-d9gxew91	257	12	tyrosine	tyrosine	NN
cord-015910-d9gxew91	257	13	phosphorylation	phosphorylation	NN
cord-015910-d9gxew91	257	14	and	and	CC
cord-015910-d9gxew91	257	15	its	-PRON-	PRP$
cord-015910-d9gxew91	257	16	association	association	NN
cord-015910-d9gxew91	257	17	with	with	IN
cord-015910-d9gxew91	257	18	the	the	DT
cord-015910-d9gxew91	257	19	p85	p85	NN
cord-015910-d9gxew91	257	20	regulatory	regulatory	JJ
cord-015910-d9gxew91	257	21	subunit	subunit	NN
cord-015910-d9gxew91	257	22	of	of	IN
cord-015910-d9gxew91	257	23	phosphatidylinositol-3	phosphatidylinositol-3	NNP
cord-015910-d9gxew91	257	24	kinase	kinase	NN
cord-015910-d9gxew91	257	25	(	(	-LRB-
cord-015910-d9gxew91	257	26	Emanuelli	Emanuelli	NNP
cord-015910-d9gxew91	257	27	,	,	,
cord-015910-d9gxew91	257	28	Peraldi	Peraldi	NNP
cord-015910-d9gxew91	257	29	,	,	,
cord-015910-d9gxew91	257	30	&	&	CC
cord-015910-d9gxew91	257	31	Filloux	Filloux	NNP
cord-015910-d9gxew91	257	32	,	,	,
cord-015910-d9gxew91	257	33	2001	2001	CD
cord-015910-d9gxew91	257	34	)	)	-RRB-
cord-015910-d9gxew91	257	35	.	.	.
cord-015910-d9gxew91	258	1	These	these	DT
cord-015910-d9gxew91	258	2	observations	observation	NNS
cord-015910-d9gxew91	258	3	therefore	therefore	RB
cord-015910-d9gxew91	258	4	suggest	suggest	VBP
cord-015910-d9gxew91	258	5	that	that	IN
cord-015910-d9gxew91	258	6	SOCS-3	SOCS-3	NNP
cord-015910-d9gxew91	258	7	may	may	MD
cord-015910-d9gxew91	258	8	be	be	VB
cord-015910-d9gxew91	258	9	a	a	DT
cord-015910-d9gxew91	258	10	key	key	JJ
cord-015910-d9gxew91	258	11	mediator	mediator	NN
cord-015910-d9gxew91	258	12	in	in	IN
cord-015910-d9gxew91	258	13	the	the	DT
cord-015910-d9gxew91	258	14	development	development	NN
cord-015910-d9gxew91	258	15	of	of	IN
cord-015910-d9gxew91	258	16	insulin	insulin	NN
cord-015910-d9gxew91	258	17	sensitivity	sensitivity	NN
cord-015910-d9gxew91	258	18	during	during	IN
cord-015910-d9gxew91	258	19	inflammation	inflammation	NN
cord-015910-d9gxew91	258	20	.	.	.
cord-015910-d9gxew91	259	1	Obesity	obesity	NN
cord-015910-d9gxew91	259	2	is	be	VBZ
cord-015910-d9gxew91	259	3	associated	associate	VBN
cord-015910-d9gxew91	259	4	with	with	IN
cord-015910-d9gxew91	259	5	insulin	insulin	NN
cord-015910-d9gxew91	259	6	resistance	resistance	NN
cord-015910-d9gxew91	259	7	,	,	,
cord-015910-d9gxew91	259	8	particularly	particularly	RB
cord-015910-d9gxew91	259	9	when	when	WRB
cord-015910-d9gxew91	259	10	body	body	NN
cord-015910-d9gxew91	259	11	fat	fat	NN
cord-015910-d9gxew91	259	12	has	have	VBZ
cord-015910-d9gxew91	259	13	a	a	DT
cord-015910-d9gxew91	259	14	central	central	JJ
cord-015910-d9gxew91	259	15	distribution	distribution	NN
cord-015910-d9gxew91	259	16	.	.	.
cord-015910-d9gxew91	260	1	While	while	IN
cord-015910-d9gxew91	260	2	elevated	elevated	JJ
cord-015910-d9gxew91	260	3	plasma	plasma	NN
cord-015910-d9gxew91	260	4	leptin	leptin	NN
cord-015910-d9gxew91	260	5	concentrations	concentration	NNS
cord-015910-d9gxew91	260	6	are	be	VBP
cord-015910-d9gxew91	260	7	associated	associate	VBN
cord-015910-d9gxew91	260	8	with	with	IN
cord-015910-d9gxew91	260	9	obesity	obesity	NN
cord-015910-d9gxew91	260	10	,	,	,
cord-015910-d9gxew91	260	11	some	some	DT
cord-015910-d9gxew91	260	12	studies	study	NNS
cord-015910-d9gxew91	260	13	have	have	VBP
cord-015910-d9gxew91	260	14	suggested	suggest	VBN
cord-015910-d9gxew91	260	15	that	that	IN
cord-015910-d9gxew91	260	16	insulin	insulin	NN
cord-015910-d9gxew91	260	17	sensitivity	sensitivity	NN
cord-015910-d9gxew91	260	18	is	be	VBZ
cord-015910-d9gxew91	260	19	an	an	DT
cord-015910-d9gxew91	260	20	additional	additional	JJ
cord-015910-d9gxew91	260	21	determinant	determinant	NN
cord-015910-d9gxew91	260	22	of	of	IN
cord-015910-d9gxew91	260	23	circulating	circulate	VBG
cord-015910-d9gxew91	260	24	leptin	leptin	NN
cord-015910-d9gxew91	260	25	concentrations	concentration	NNS
cord-015910-d9gxew91	260	26	.	.	.
cord-015910-d9gxew91	261	1	Leptin	leptin	NN
cord-015910-d9gxew91	261	2	is	be	VBZ
cord-015910-d9gxew91	261	3	produced	produce	VBN
cord-015910-d9gxew91	261	4	by	by	IN
cord-015910-d9gxew91	261	5	adipose	adipose	JJ
cord-015910-d9gxew91	261	6	tissue	tissue	NN
cord-015910-d9gxew91	261	7	in	in	IN
cord-015910-d9gxew91	261	8	proportion	proportion	NN
cord-015910-d9gxew91	261	9	to	to	IN
cord-015910-d9gxew91	261	10	adipose	adipose	JJ
cord-015910-d9gxew91	261	11	tissue	tissue	NN
cord-015910-d9gxew91	261	12	mass	mass	NN
cord-015910-d9gxew91	261	13	and	and	CC
cord-015910-d9gxew91	261	14	is	be	VBZ
cord-015910-d9gxew91	261	15	a	a	DT
cord-015910-d9gxew91	261	16	pleiotropic	pleiotropic	JJ
cord-015910-d9gxew91	261	17	molecule	molecule	NN
cord-015910-d9gxew91	261	18	.	.	.
cord-015910-d9gxew91	262	1	In	in	IN
cord-015910-d9gxew91	262	2	addition	addition	NN
cord-015910-d9gxew91	262	3	to	to	IN
cord-015910-d9gxew91	262	4	playing	play	VBG
cord-015910-d9gxew91	262	5	a	a	DT
cord-015910-d9gxew91	262	6	role	role	NN
cord-015910-d9gxew91	262	7	in	in	IN
cord-015910-d9gxew91	262	8	appetite	appetite	NN
cord-015910-d9gxew91	262	9	and	and	CC
cord-015910-d9gxew91	262	10	adipose	adipose	JJ
cord-015910-d9gxew91	262	11	tissue	tissue	NN
cord-015910-d9gxew91	262	12	regulation	regulation	NN
cord-015910-d9gxew91	262	13	,	,	,
cord-015910-d9gxew91	262	14	leptin	leptin	NN
cord-015910-d9gxew91	262	15	influences	influence	NNS
cord-015910-d9gxew91	262	16	immune	immune	JJ
cord-015910-d9gxew91	262	17	functions	function	NNS
cord-015910-d9gxew91	262	18	.	.	.
cord-015910-d9gxew91	263	1	Leptin	leptin	NN
cord-015910-d9gxew91	263	2	concentrations	concentration	NNS
cord-015910-d9gxew91	263	3	increase	increase	VBP
cord-015910-d9gxew91	263	4	acutely	acutely	RB
cord-015910-d9gxew91	263	5	during	during	IN
cord-015910-d9gxew91	263	6	inflammation	inflammation	NN
cord-015910-d9gxew91	263	7	and	and	CC
cord-015910-d9gxew91	263	8	regulate	regulate	VB
cord-015910-d9gxew91	263	9	T	t	NN
cord-015910-d9gxew91	263	10	-	-	HYPH
cord-015910-d9gxew91	263	11	cell	cell	NN
cord-015910-d9gxew91	263	12	responses	response	NNS
cord-015910-d9gxew91	263	13	,	,	,
cord-015910-d9gxew91	263	14	polarizing	polarize	VBG
cord-015910-d9gxew91	263	15	T	t	NN
cord-015910-d9gxew91	263	16	-	-	HYPH
cord-015910-d9gxew91	263	17	helper	helper	NN
cord-015910-d9gxew91	263	18	(	(	-LRB-
cord-015910-d9gxew91	263	19	Th	Th	NNP
cord-015910-d9gxew91	263	20	)	)	-RRB-
cord-015910-d9gxew91	263	21	cells	cell	NNS
cord-015910-d9gxew91	263	22	toward	toward	IN
cord-015910-d9gxew91	263	23	a	a	DT
cord-015910-d9gxew91	263	24	Th	Th	NNP
cord-015910-d9gxew91	263	25	1	1	CD
cord-015910-d9gxew91	263	26	phenotype	phenotype	NN
cord-015910-d9gxew91	263	27	.	.	.
cord-015910-d9gxew91	264	1	Thus	thus	RB
cord-015910-d9gxew91	264	2	,	,	,
cord-015910-d9gxew91	264	3	increased	increase	VBN
cord-015910-d9gxew91	264	4	leptin	leptin	NN
cord-015910-d9gxew91	264	5	production	production	NN
cord-015910-d9gxew91	264	6	during	during	IN
cord-015910-d9gxew91	264	7	obesity	obesity	NN
cord-015910-d9gxew91	264	8	,	,	,
cord-015910-d9gxew91	264	9	may	may	MD
cord-015910-d9gxew91	264	10	exert	exert	VB
cord-015910-d9gxew91	264	11	a	a	DT
cord-015910-d9gxew91	264	12	pro	pro	JJ
cord-015910-d9gxew91	264	13	-	-	JJ
cord-015910-d9gxew91	264	14	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	264	15	influence	influence	NN
cord-015910-d9gxew91	264	16	(	(	-LRB-
cord-015910-d9gxew91	264	17	Faggioni	Faggioni	NNP
cord-015910-d9gxew91	264	18	,	,	,
cord-015910-d9gxew91	264	19	Feingold	Feingold	NNP
cord-015910-d9gxew91	264	20	,	,	,
cord-015910-d9gxew91	264	21	&	&	CC
cord-015910-d9gxew91	264	22	Grunfeld	Grunfeld	NNP
cord-015910-d9gxew91	264	23	,	,	,
cord-015910-d9gxew91	264	24	2001	2001	CD
cord-015910-d9gxew91	264	25	)	)	-RRB-
cord-015910-d9gxew91	264	26	.	.	.
cord-015910-d9gxew91	265	1	Further	further	JJ
cord-015910-d9gxew91	265	2	complexity	complexity	NN
cord-015910-d9gxew91	265	3	is	be	VBZ
cord-015910-d9gxew91	265	4	added	add	VBN
cord-015910-d9gxew91	265	5	to	to	IN
cord-015910-d9gxew91	265	6	the	the	DT
cord-015910-d9gxew91	265	7	concept	concept	NN
cord-015910-d9gxew91	265	8	of	of	IN
cord-015910-d9gxew91	265	9	a	a	DT
cord-015910-d9gxew91	265	10	link	link	NN
cord-015910-d9gxew91	265	11	between	between	IN
cord-015910-d9gxew91	265	12	insulin	insulin	NN
cord-015910-d9gxew91	265	13	sensitivity	sensitivity	NN
cord-015910-d9gxew91	265	14	,	,	,
cord-015910-d9gxew91	265	15	inflammation	inflammation	NN
cord-015910-d9gxew91	265	16	,	,	,
cord-015910-d9gxew91	265	17	and	and	CC
cord-015910-d9gxew91	265	18	obesity	obesity	NN
cord-015910-d9gxew91	265	19	by	by	IN
cord-015910-d9gxew91	265	20	the	the	DT
cord-015910-d9gxew91	265	21	results	result	NNS
cord-015910-d9gxew91	265	22	of	of	IN
cord-015910-d9gxew91	265	23	a	a	DT
cord-015910-d9gxew91	265	24	study	study	NN
cord-015910-d9gxew91	265	25	of	of	IN
cord-015910-d9gxew91	265	26	268	268	CD
cord-015910-d9gxew91	265	27	individuals	individual	NNS
cord-015910-d9gxew91	265	28	selected	select	VBN
cord-015910-d9gxew91	265	29	from	from	IN
cord-015910-d9gxew91	265	30	the	the	DT
cord-015910-d9gxew91	265	31	Health	Health	NNP
cord-015910-d9gxew91	265	32	Professionals	Professionals	NNPS
cord-015910-d9gxew91	265	33	follow	follow	VB
cord-015910-d9gxew91	265	34	-	-	HYPH
cord-015910-d9gxew91	265	35	up	up	NN
cord-015910-d9gxew91	265	36	study	study	NN
cord-015910-d9gxew91	265	37	in	in	IN
cord-015910-d9gxew91	265	38	the	the	DT
cord-015910-d9gxew91	265	39	United	United	NNP
cord-015910-d9gxew91	265	40	States	States	NNP
cord-015910-d9gxew91	265	41	(	(	-LRB-
cord-015910-d9gxew91	265	42	Chu	Chu	NNP
cord-015910-d9gxew91	265	43	,	,	,
cord-015910-d9gxew91	265	44	Spiegelman	Spiegelman	NNP
cord-015910-d9gxew91	265	45	,	,	,
cord-015910-d9gxew91	265	46	&	&	CC
cord-015910-d9gxew91	265	47	Hotamisligil	Hotamisligil	NNP
cord-015910-d9gxew91	265	48	,	,	,
cord-015910-d9gxew91	265	49	2001	2001	CD
cord-015910-d9gxew91	265	50	)	)	-RRB-
cord-015910-d9gxew91	265	51	.	.	.
cord-015910-d9gxew91	266	1	In	in	IN
cord-015910-d9gxew91	266	2	the	the	DT
cord-015910-d9gxew91	266	3	study	study	NN
cord-015910-d9gxew91	266	4	plasma	plasma	NN
cord-015910-d9gxew91	266	5	insulin	insulin	NN
cord-015910-d9gxew91	266	6	,	,	,
cord-015910-d9gxew91	266	7	leptin	leptin	NN
cord-015910-d9gxew91	266	8	,	,	,
cord-015910-d9gxew91	266	9	and	and	CC
cord-015910-d9gxew91	266	10	soluble	soluble	JJ
cord-015910-d9gxew91	266	11	TNF	TNF	NNP
cord-015910-d9gxew91	266	12	receptor	receptor	NN
cord-015910-d9gxew91	266	13	(	(	-LRB-
cord-015910-d9gxew91	266	14	sTNF	stnf	NN
cord-015910-d9gxew91	266	15	-	-	HYPH
cord-015910-d9gxew91	266	16	R	r	NN
cord-015910-d9gxew91	266	17	,	,	,
cord-015910-d9gxew91	266	18	an	an	DT
cord-015910-d9gxew91	266	19	index	index	NN
cord-015910-d9gxew91	266	20	of	of	IN
cord-015910-d9gxew91	266	21	TNF	TNF	NNP
cord-015910-d9gxew91	266	22	-	-	HYPH
cord-015910-d9gxew91	266	23	o~	o~	CD
cord-015910-d9gxew91	266	24	production	production	NN
cord-015910-d9gxew91	266	25	)	)	-RRB-
cord-015910-d9gxew91	266	26	concentrations	concentration	NNS
cord-015910-d9gxew91	266	27	were	be	VBD
cord-015910-d9gxew91	266	28	measured	measure	VBN
cord-015910-d9gxew91	266	29	and	and	CC
cord-015910-d9gxew91	266	30	correlated	correlate	VBN
cord-015910-d9gxew91	266	31	with	with	IN
cord-015910-d9gxew91	266	32	BMI	BMI	NNP
cord-015910-d9gxew91	266	33	and	and	CC
cord-015910-d9gxew91	266	34	the	the	DT
cord-015910-d9gxew91	266	35	CVD	CVD	NNP
cord-015910-d9gxew91	266	36	risk	risk	NN
cord-015910-d9gxew91	266	37	factors	factor	NNS
cord-015910-d9gxew91	266	38	insulin	insulin	NN
cord-015910-d9gxew91	266	39	,	,	,
cord-015910-d9gxew91	266	40	triglyceride	triglyceride	NN
cord-015910-d9gxew91	266	41	,	,	,
cord-015910-d9gxew91	266	42	t	t	NNP
cord-015910-d9gxew91	266	43	-	-	HYPH
cord-015910-d9gxew91	266	44	PA	PA	NNP
cord-015910-d9gxew91	266	45	antigen	antigen	NN
cord-015910-d9gxew91	266	46	levels	level	NNS
cord-015910-d9gxew91	266	47	,	,	,
cord-015910-d9gxew91	266	48	and	and	CC
cord-015910-d9gxew91	266	49	apolipoprotein	apolipoprotein	NN
cord-015910-d9gxew91	266	50	(	(	-LRB-
cord-015910-d9gxew91	266	51	Apo)-A1	Apo)-A1	NNP
cord-015910-d9gxew91	266	52	.	.	.
cord-015910-d9gxew91	267	1	In	in	IN
cord-015910-d9gxew91	267	2	a	a	DT
cord-015910-d9gxew91	267	3	multivariate	multivariate	JJ
cord-015910-d9gxew91	267	4	regression	regression	NN
cord-015910-d9gxew91	267	5	model	model	NN
cord-015910-d9gxew91	267	6	controlling	control	VBG
cord-015910-d9gxew91	267	7	for	for	IN
cord-015910-d9gxew91	267	8	age	age	NN
cord-015910-d9gxew91	267	9	,	,	,
cord-015910-d9gxew91	267	10	smoking	smoking	NN
cord-015910-d9gxew91	267	11	,	,	,
cord-015910-d9gxew91	267	12	alcohol	alcohol	NN
cord-015910-d9gxew91	267	13	intake	intake	NN
cord-015910-d9gxew91	267	14	,	,	,
cord-015910-d9gxew91	267	15	physical	physical	JJ
cord-015910-d9gxew91	267	16	activity	activity	NN
cord-015910-d9gxew91	267	17	,	,	,
cord-015910-d9gxew91	267	18	and	and	CC
cord-015910-d9gxew91	267	19	diet	diet	NN
cord-015910-d9gxew91	267	20	,	,	,
cord-015910-d9gxew91	267	21	BMI	BMI	NNP
cord-015910-d9gxew91	267	22	was	be	VBD
cord-015910-d9gxew91	267	23	inversely	inversely	RB
cord-015910-d9gxew91	267	24	associated	associate	VBN
cord-015910-d9gxew91	267	25	with	with	IN
cord-015910-d9gxew91	267	26	HDL	HDL	NNP
cord-015910-d9gxew91	267	27	cholesterol	cholesterol	NN
cord-015910-d9gxew91	267	28	and	and	CC
cord-015910-d9gxew91	267	29	Apo	Apo	NNP
cord-015910-d9gxew91	267	30	-	-	HYPH
cord-015910-d9gxew91	267	31	A1	A1	NNP
cord-015910-d9gxew91	267	32	and	and	CC
cord-015910-d9gxew91	267	33	positively	positively	RB
cord-015910-d9gxew91	267	34	associated	associate	VBN
cord-015910-d9gxew91	267	35	with	with	IN
cord-015910-d9gxew91	267	36	trigyceride	trigyceride	NN
cord-015910-d9gxew91	267	37	,	,	,
cord-015910-d9gxew91	267	38	Apo	Apo	NNP
cord-015910-d9gxew91	267	39	-	-	HYPH
cord-015910-d9gxew91	267	40	B	B	NNP
cord-015910-d9gxew91	267	41	,	,	,
cord-015910-d9gxew91	267	42	and	and	CC
cord-015910-d9gxew91	267	43	t	t	NNP
cord-015910-d9gxew91	267	44	-	-	HYPH
cord-015910-d9gxew91	267	45	PA	PA	NNP
cord-015910-d9gxew91	267	46	antigen	antigen	NN
cord-015910-d9gxew91	267	47	levels	level	NNS
cord-015910-d9gxew91	267	48	.	.	.
cord-015910-d9gxew91	268	1	The	the	DT
cord-015910-d9gxew91	268	2	associations	association	NNS
cord-015910-d9gxew91	268	3	between	between	IN
cord-015910-d9gxew91	268	4	BMI	BMI	NNP
cord-015910-d9gxew91	268	5	and	and	CC
cord-015910-d9gxew91	268	6	these	these	DT
cord-015910-d9gxew91	268	7	CVD	CVD	NNP
cord-015910-d9gxew91	268	8	risk	risk	NN
cord-015910-d9gxew91	268	9	factors	factor	NNS
cord-015910-d9gxew91	268	10	were	be	VBD
cord-015910-d9gxew91	268	11	only	only	RB
cord-015910-d9gxew91	268	12	slightly	slightly	RB
cord-015910-d9gxew91	268	13	changed	change	VBN
cord-015910-d9gxew91	268	14	after	after	IN
cord-015910-d9gxew91	268	15	adjusting	adjust	VBG
cord-015910-d9gxew91	268	16	for	for	IN
cord-015910-d9gxew91	268	17	leptin	leptin	NN
cord-015910-d9gxew91	268	18	and/or	and/or	CC
cord-015910-d9gxew91	268	19	sTNF	stnf	NN
cord-015910-d9gxew91	268	20	-	-	HYPH
cord-015910-d9gxew91	268	21	R	r	NN
cord-015910-d9gxew91	268	22	,	,	,
cord-015910-d9gxew91	268	23	but	but	CC
cord-015910-d9gxew91	268	24	were	be	VBD
cord-015910-d9gxew91	268	25	substantially	substantially	RB
cord-015910-d9gxew91	268	26	attenuated	attenuate	VBN
cord-015910-d9gxew91	268	27	after	after	IN
cord-015910-d9gxew91	268	28	controlling	control	VBG
cord-015910-d9gxew91	268	29	for	for	IN
cord-015910-d9gxew91	268	30	insulin	insulin	NN
cord-015910-d9gxew91	268	31	levels	level	NNS
cord-015910-d9gxew91	268	32	.	.	.
cord-015910-d9gxew91	269	1	These	these	DT
cord-015910-d9gxew91	269	2	data	datum	NNS
cord-015910-d9gxew91	269	3	suggest	suggest	VBP
cord-015910-d9gxew91	269	4	that	that	IN
cord-015910-d9gxew91	269	5	the	the	DT
cord-015910-d9gxew91	269	6	association	association	NN
cord-015910-d9gxew91	269	7	between	between	IN
cord-015910-d9gxew91	269	8	obesity	obesity	NN
cord-015910-d9gxew91	269	9	and	and	CC
cord-015910-d9gxew91	269	10	biological	biological	JJ
cord-015910-d9gxew91	269	11	predictors	predictor	NNS
cord-015910-d9gxew91	269	12	of	of	IN
cord-015910-d9gxew91	269	13	CVD	CVD	NNP
cord-015910-d9gxew91	269	14	may	may	MD
cord-015910-d9gxew91	269	15	be	be	VB
cord-015910-d9gxew91	269	16	mediated	mediate	VBN
cord-015910-d9gxew91	269	17	through	through	IN
cord-015910-d9gxew91	269	18	changes	change	NNS
cord-015910-d9gxew91	269	19	in	in	IN
cord-015910-d9gxew91	269	20	plasma	plasma	NN
cord-015910-d9gxew91	269	21	insulin	insulin	NN
cord-015910-d9gxew91	269	22	,	,	,
cord-015910-d9gxew91	269	23	rather	rather	RB
cord-015910-d9gxew91	269	24	than	than	IN
cord-015910-d9gxew91	269	25	leptin	leptin	NN
cord-015910-d9gxew91	269	26	or	or	CC
cord-015910-d9gxew91	269	27	sTNF	stnf	NN
cord-015910-d9gxew91	269	28	-	-	HYPH
cord-015910-d9gxew91	269	29	R	r	NN
cord-015910-d9gxew91	269	30	levels	level	NNS
cord-015910-d9gxew91	269	31	,	,	,
cord-015910-d9gxew91	269	32	and	and	CC
cord-015910-d9gxew91	269	33	that	that	IN
cord-015910-d9gxew91	269	34	insulin	insulin	NN
cord-015910-d9gxew91	269	35	may	may	MD
cord-015910-d9gxew91	269	36	be	be	VB
cord-015910-d9gxew91	269	37	exerting	exert	VBG
cord-015910-d9gxew91	269	38	an	an	DT
cord-015910-d9gxew91	269	39	anti	anti	JJ
cord-015910-d9gxew91	269	40	-	-	JJ
cord-015910-d9gxew91	269	41	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	269	42	effect	effect	NN
cord-015910-d9gxew91	269	43	.	.	.
cord-015910-d9gxew91	270	1	(	(	-LRB-
cord-015910-d9gxew91	270	2	Cnop	Cnop	NNP
cord-015910-d9gxew91	270	3	,	,	,
cord-015910-d9gxew91	270	4	Landchild	Landchild	NNP
cord-015910-d9gxew91	270	5	,	,	,
cord-015910-d9gxew91	270	6	&	&	CC
cord-015910-d9gxew91	270	7	Vidal	Vidal	NNP
cord-015910-d9gxew91	270	8	,	,	,
cord-015910-d9gxew91	270	9	2002	2002	CD
cord-015910-d9gxew91	270	10	)	)	-RRB-
cord-015910-d9gxew91	270	11	.	.	.
cord-015910-d9gxew91	271	1	Genetic	genetic	JJ
cord-015910-d9gxew91	271	2	factors	factor	NNS
cord-015910-d9gxew91	271	3	may	may	MD
cord-015910-d9gxew91	271	4	play	play	VB
cord-015910-d9gxew91	271	5	a	a	DT
cord-015910-d9gxew91	271	6	part	part	NN
cord-015910-d9gxew91	271	7	in	in	IN
cord-015910-d9gxew91	271	8	the	the	DT
cord-015910-d9gxew91	271	9	interaction	interaction	NN
cord-015910-d9gxew91	271	10	between	between	IN
cord-015910-d9gxew91	271	11	inflammation	inflammation	NN
cord-015910-d9gxew91	271	12	,	,	,
cord-015910-d9gxew91	271	13	insulin	insulin	NN
cord-015910-d9gxew91	271	14	insensitivity	insensitivity	NN
cord-015910-d9gxew91	271	15	,	,	,
cord-015910-d9gxew91	271	16	and	and	CC
cord-015910-d9gxew91	271	17	obesity	obesity	NN
cord-015910-d9gxew91	271	18	.	.	.
cord-015910-d9gxew91	272	1	NF-~:B	NF-~:B	NNP
cord-015910-d9gxew91	272	2	is	be	VBZ
cord-015910-d9gxew91	272	3	an	an	DT
cord-015910-d9gxew91	272	4	important	important	JJ
cord-015910-d9gxew91	272	5	mediator	mediator	NN
cord-015910-d9gxew91	272	6	of	of	IN
cord-015910-d9gxew91	272	7	inflammation	inflammation	NN
cord-015910-d9gxew91	272	8	by	by	IN
cord-015910-d9gxew91	272	9	increasing	increase	VBG
cord-015910-d9gxew91	272	10	transcription	transcription	NN
cord-015910-d9gxew91	272	11	of	of	IN
cord-015910-d9gxew91	272	12	a	a	DT
cord-015910-d9gxew91	272	13	range	range	NN
cord-015910-d9gxew91	272	14	of	of	IN
cord-015910-d9gxew91	272	15	genes	gene	NNS
cord-015910-d9gxew91	272	16	central	central	JJ
cord-015910-d9gxew91	272	17	to	to	IN
cord-015910-d9gxew91	272	18	the	the	DT
cord-015910-d9gxew91	272	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	272	20	process	process	NN
cord-015910-d9gxew91	272	21	(	(	-LRB-
cord-015910-d9gxew91	272	22	cytokines	cytokine	NNS
cord-015910-d9gxew91	272	23	,	,	,
cord-015910-d9gxew91	272	24	adhesion	adhesion	NN
cord-015910-d9gxew91	272	25	molecules	molecule	NNS
cord-015910-d9gxew91	272	26	,	,	,
cord-015910-d9gxew91	272	27	acute	acute	JJ
cord-015910-d9gxew91	272	28	-	-	HYPH
cord-015910-d9gxew91	272	29	phase	phase	NN
cord-015910-d9gxew91	272	30	proteins	protein	NNS
cord-015910-d9gxew91	272	31	)	)	-RRB-
cord-015910-d9gxew91	272	32	.	.	.
cord-015910-d9gxew91	273	1	SNPs	SNPs	NNP
cord-015910-d9gxew91	273	2	in	in	IN
cord-015910-d9gxew91	273	3	the	the	DT
cord-015910-d9gxew91	273	4	NF	NF	NNP
cord-015910-d9gxew91	273	5	-	-	HYPH
cord-015910-d9gxew91	273	6	r,~B	r,~B	NNP
cord-015910-d9gxew91	273	7	gene	gene	NN
cord-015910-d9gxew91	273	8	were	be	VBD
cord-015910-d9gxew91	273	9	investigated	investigate	VBN
cord-015910-d9gxew91	273	10	in	in	IN
cord-015910-d9gxew91	273	11	a	a	DT
cord-015910-d9gxew91	273	12	group	group	NN
cord-015910-d9gxew91	273	13	of	of	IN
cord-015910-d9gxew91	273	14	217	217	CD
cord-015910-d9gxew91	273	15	type	type	NN
cord-015910-d9gxew91	273	16	1	1	CD
cord-015910-d9gxew91	273	17	diabetic	diabetic	JJ
cord-015910-d9gxew91	273	18	patients	patient	NNS
cord-015910-d9gxew91	273	19	and	and	CC
cord-015910-d9gxew91	273	20	compared	compare	VBN
cord-015910-d9gxew91	273	21	with	with	IN
cord-015910-d9gxew91	273	22	gene	gene	NN
cord-015910-d9gxew91	273	23	frequencies	frequency	NNS
cord-015910-d9gxew91	273	24	in	in	IN
cord-015910-d9gxew91	273	25	111	111	CD
cord-015910-d9gxew91	273	26	normal	normal	JJ
cord-015910-d9gxew91	273	27	controls	control	NNS
cord-015910-d9gxew91	273	28	.	.	.
cord-015910-d9gxew91	274	1	It	-PRON-	PRP
cord-015910-d9gxew91	274	2	was	be	VBD
cord-015910-d9gxew91	274	3	found	find	VBN
cord-015910-d9gxew91	274	4	that	that	IN
cord-015910-d9gxew91	274	5	there	there	EX
cord-015910-d9gxew91	274	6	was	be	VBD
cord-015910-d9gxew91	274	7	a	a	DT
cord-015910-d9gxew91	274	8	higher	high	JJR
cord-015910-d9gxew91	274	9	frequency	frequency	NN
cord-015910-d9gxew91	274	10	of	of	IN
cord-015910-d9gxew91	274	11	allele	allele	NN
cord-015910-d9gxew91	274	12	138	138	CD
cord-015910-d9gxew91	274	13	bp	bp	NNP
cord-015910-d9gxew91	274	14	(	(	-LRB-
cord-015910-d9gxew91	274	15	A10	A10	NNP
cord-015910-d9gxew91	274	16	)	)	-RRB-
cord-015910-d9gxew91	274	17	(	(	-LRB-
cord-015910-d9gxew91	274	18	high	high	JJ
cord-015910-d9gxew91	274	19	bioactivity	bioactivity	NN
cord-015910-d9gxew91	274	20	)	)	-RRB-
cord-015910-d9gxew91	274	21	and	and	CC
cord-015910-d9gxew91	274	22	a	a	DT
cord-015910-d9gxew91	274	23	lower	low	JJR
cord-015910-d9gxew91	274	24	frequency	frequency	NN
cord-015910-d9gxew91	274	25	of	of	IN
cord-015910-d9gxew91	274	26	allele	allele	NN
cord-015910-d9gxew91	274	27	146	146	CD
cord-015910-d9gxew91	274	28	bp	bp	NNP
cord-015910-d9gxew91	274	29	(	(	-LRB-
cord-015910-d9gxew91	274	30	A14	A14	NNP
cord-015910-d9gxew91	274	31	)	)	-RRB-
cord-015910-d9gxew91	274	32	(	(	-LRB-
cord-015910-d9gxew91	274	33	less	less	RBR
cord-015910-d9gxew91	274	34	bioactive	bioactive	JJ
cord-015910-d9gxew91	274	35	)	)	-RRB-
cord-015910-d9gxew91	274	36	in	in	IN
cord-015910-d9gxew91	274	37	diabetics	diabetic	NNS
cord-015910-d9gxew91	274	38	than	than	IN
cord-015910-d9gxew91	274	39	in	in	IN
cord-015910-d9gxew91	274	40	controls	control	NNS
cord-015910-d9gxew91	274	41	.	.	.
cord-015910-d9gxew91	275	1	Genotype	Genotype	NNP
cord-015910-d9gxew91	275	2	may	may	MD
cord-015910-d9gxew91	275	3	thus	thus	RB
cord-015910-d9gxew91	275	4	contribute	contribute	VB
cord-015910-d9gxew91	275	5	to	to	IN
cord-015910-d9gxew91	275	6	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	275	7	stress	stress	NN
cord-015910-d9gxew91	275	8	in	in	IN
cord-015910-d9gxew91	275	9	diabetes	diabetes	NN
cord-015910-d9gxew91	275	10	mellitus	mellitus	NN
cord-015910-d9gxew91	275	11	(	(	-LRB-
cord-015910-d9gxew91	275	12	Hegazy	Hegazy	NNP
cord-015910-d9gxew91	275	13	,	,	,
cord-015910-d9gxew91	275	14	O'Reilly	O'Reilly	NNP
cord-015910-d9gxew91	275	15	,	,	,
cord-015910-d9gxew91	275	16	&	&	CC
cord-015910-d9gxew91	275	17	Yang	Yang	NNP
cord-015910-d9gxew91	275	18	,	,	,
cord-015910-d9gxew91	275	19	2001	2001	CD
cord-015910-d9gxew91	275	20	)	)	-RRB-
cord-015910-d9gxew91	275	21	.	.	.
cord-015910-d9gxew91	276	1	NF-~:B	NF-~:B	NNP
cord-015910-d9gxew91	276	2	may	may	MD
cord-015910-d9gxew91	276	3	also	also	RB
cord-015910-d9gxew91	276	4	provide	provide	VB
cord-015910-d9gxew91	276	5	an	an	DT
cord-015910-d9gxew91	276	6	important	important	JJ
cord-015910-d9gxew91	276	7	focus	focus	NN
cord-015910-d9gxew91	276	8	for	for	IN
cord-015910-d9gxew91	276	9	PPAR-7	PPAR-7	NNP
cord-015910-d9gxew91	276	10	action	action	NN
cord-015910-d9gxew91	276	11	,	,	,
cord-015910-d9gxew91	276	12	because	because	IN
cord-015910-d9gxew91	276	13	it	-PRON-	PRP
cord-015910-d9gxew91	276	14	has	have	VBZ
cord-015910-d9gxew91	276	15	been	be	VBN
cord-015910-d9gxew91	276	16	shown	show	VBN
cord-015910-d9gxew91	276	17	in	in	IN
cord-015910-d9gxew91	276	18	a	a	DT
cord-015910-d9gxew91	276	19	number	number	NN
cord-015910-d9gxew91	276	20	of	of	IN
cord-015910-d9gxew91	276	21	studies	study	NNS
cord-015910-d9gxew91	276	22	that	that	WDT
cord-015910-d9gxew91	276	23	PPAR-~/in	ppar-~/in	NN
cord-015910-d9gxew91	276	24	combination	combination	NN
cord-015910-d9gxew91	276	25	with	with	IN
cord-015910-d9gxew91	276	26	retinoid	retinoid	NN
cord-015910-d9gxew91	276	27	X	x	NN
cord-015910-d9gxew91	276	28	receptor	receptor	NN
cord-015910-d9gxew91	276	29	is	be	VBZ
cord-015910-d9gxew91	276	30	able	able	JJ
cord-015910-d9gxew91	276	31	to	to	TO
cord-015910-d9gxew91	276	32	inhibit	inhibit	VB
cord-015910-d9gxew91	276	33	NF-~:B	NF-~:B	NNP
cord-015910-d9gxew91	276	34	activation	activation	NN
cord-015910-d9gxew91	276	35	(	(	-LRB-
cord-015910-d9gxew91	276	36	Wada	Wada	NNP
cord-015910-d9gxew91	276	37	,	,	,
cord-015910-d9gxew91	276	38	Nakajima	Nakajima	NNP
cord-015910-d9gxew91	276	39	,	,	,
cord-015910-d9gxew91	276	40	&	&	CC
cord-015910-d9gxew91	276	41	Blumberg	Blumberg	NNP
cord-015910-d9gxew91	276	42	,	,	,
cord-015910-d9gxew91	276	43	2001	2001	CD
cord-015910-d9gxew91	276	44	;	;	:
cord-015910-d9gxew91	276	45	Fruchart	Fruchart	NNP
cord-015910-d9gxew91	276	46	,	,	,
cord-015910-d9gxew91	276	47	Staels	Staels	NNP
cord-015910-d9gxew91	276	48	,	,	,
cord-015910-d9gxew91	276	49	&	&	CC
cord-015910-d9gxew91	276	50	Durlez	Durlez	NNP
cord-015910-d9gxew91	276	51	,	,	,
cord-015910-d9gxew91	276	52	2001	2001	CD
cord-015910-d9gxew91	276	53	;	;	:
cord-015910-d9gxew91	276	54	Debril	Debril	NNP
cord-015910-d9gxew91	276	55	,	,	,
cord-015910-d9gxew91	276	56	Renaud	Renaud	NNP
cord-015910-d9gxew91	276	57	,	,	,
cord-015910-d9gxew91	276	58	Fajas	Fajas	NNP
cord-015910-d9gxew91	276	59	,	,	,
cord-015910-d9gxew91	276	60	&	&	CC
cord-015910-d9gxew91	276	61	Auwerx	Auwerx	NNP
cord-015910-d9gxew91	276	62	,	,	,
cord-015910-d9gxew91	276	63	2001	2001	CD
cord-015910-d9gxew91	276	64	)	)	-RRB-
cord-015910-d9gxew91	276	65	.	.	.
cord-015910-d9gxew91	277	1	It	-PRON-	PRP
cord-015910-d9gxew91	277	2	is	be	VBZ
cord-015910-d9gxew91	277	3	interesting	interesting	JJ
cord-015910-d9gxew91	277	4	to	to	TO
cord-015910-d9gxew91	277	5	note	note	VB
cord-015910-d9gxew91	277	6	that	that	IN
cord-015910-d9gxew91	277	7	the	the	DT
cord-015910-d9gxew91	277	8	n-3	n-3	JJ
cord-015910-d9gxew91	277	9	polyunsaturated	polyunsaturated	JJ
cord-015910-d9gxew91	277	10	fatty	fatty	JJ
cord-015910-d9gxew91	277	11	acids	acid	NNS
cord-015910-d9gxew91	277	12	(	(	-LRB-
cord-015910-d9gxew91	277	13	PUFAs	pufa	NNS
cord-015910-d9gxew91	277	14	)	)	-RRB-
cord-015910-d9gxew91	277	15	,	,	,
cord-015910-d9gxew91	277	16	found	find	VBN
cord-015910-d9gxew91	277	17	in	in	IN
cord-015910-d9gxew91	277	18	abundance	abundance	NN
cord-015910-d9gxew91	277	19	in	in	IN
cord-015910-d9gxew91	277	20	fish	fish	NN
cord-015910-d9gxew91	277	21	oil	oil	NN
cord-015910-d9gxew91	277	22	,	,	,
cord-015910-d9gxew91	277	23	are	be	VBP
cord-015910-d9gxew91	277	24	PPAR	PPAR	NNP
cord-015910-d9gxew91	277	25	-	-	HYPH
cord-015910-d9gxew91	277	26	y	y	NNP
cord-015910-d9gxew91	277	27	agonists	agonist	NNS
cord-015910-d9gxew91	277	28	,	,	,
cord-015910-d9gxew91	277	29	raising	raise	VBG
cord-015910-d9gxew91	277	30	the	the	DT
cord-015910-d9gxew91	277	31	possibility	possibility	NN
cord-015910-d9gxew91	277	32	that	that	IN
cord-015910-d9gxew91	277	33	the	the	DT
cord-015910-d9gxew91	277	34	oil	oil	NN
cord-015910-d9gxew91	277	35	may	may	MD
cord-015910-d9gxew91	277	36	exert	exert	VB
cord-015910-d9gxew91	277	37	its	-PRON-	PRP$
cord-015910-d9gxew91	277	38	anti	anti	JJ
cord-015910-d9gxew91	277	39	-	-	JJ
cord-015910-d9gxew91	277	40	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	277	41	effects	effect	NNS
cord-015910-d9gxew91	277	42	partly	partly	RB
cord-015910-d9gxew91	277	43	via	via	IN
cord-015910-d9gxew91	277	44	this	this	DT
cord-015910-d9gxew91	277	45	mechanism	mechanism	NN
cord-015910-d9gxew91	277	46	.	.	.
cord-015910-d9gxew91	278	1	In	in	IN
cord-015910-d9gxew91	278	2	an	an	DT
cord-015910-d9gxew91	278	3	investigation	investigation	NN
cord-015910-d9gxew91	278	4	of	of	IN
cord-015910-d9gxew91	278	5	cytokine	cytokine	NN
cord-015910-d9gxew91	278	6	production	production	NN
cord-015910-d9gxew91	278	7	in	in	IN
cord-015910-d9gxew91	278	8	139	139	CD
cord-015910-d9gxew91	278	9	healthy	healthy	JJ
cord-015910-d9gxew91	278	10	males	male	NNS
cord-015910-d9gxew91	278	11	,	,	,
cord-015910-d9gxew91	278	12	the	the	DT
cord-015910-d9gxew91	278	13	author	author	NN
cord-015910-d9gxew91	278	14	found	find	VBD
cord-015910-d9gxew91	278	15	that	that	IN
cord-015910-d9gxew91	278	16	in	in	IN
cord-015910-d9gxew91	278	17	the	the	DT
cord-015910-d9gxew91	278	18	study	study	NN
cord-015910-d9gxew91	278	19	population	population	NN
cord-015910-d9gxew91	278	20	as	as	IN
cord-015910-d9gxew91	278	21	a	a	DT
cord-015910-d9gxew91	278	22	whole	whole	NN
cord-015910-d9gxew91	278	23	there	there	EX
cord-015910-d9gxew91	278	24	were	be	VBD
cord-015910-d9gxew91	278	25	no	no	DT
cord-015910-d9gxew91	278	26	statistically	statistically	RB
cord-015910-d9gxew91	278	27	significant	significant	JJ
cord-015910-d9gxew91	278	28	relationships	relationship	NNS
cord-015910-d9gxew91	278	29	between	between	IN
cord-015910-d9gxew91	278	30	BMI	BMI	NNP
cord-015910-d9gxew91	278	31	,	,	,
cord-015910-d9gxew91	278	32	plasma	plasma	NN
cord-015910-d9gxew91	278	33	fasting	fast	VBG
cord-015910-d9gxew91	278	34	triglycerides	triglyceride	NNS
cord-015910-d9gxew91	278	35	,	,	,
cord-015910-d9gxew91	278	36	and	and	CC
cord-015910-d9gxew91	278	37	the	the	DT
cord-015910-d9gxew91	278	38	ability	ability	NN
cord-015910-d9gxew91	278	39	of	of	IN
cord-015910-d9gxew91	278	40	PBMCs	pbmc	NNS
cord-015910-d9gxew91	278	41	to	to	TO
cord-015910-d9gxew91	278	42	produce	produce	VB
cord-015910-d9gxew91	278	43	TNF	TNF	NNP
cord-015910-d9gxew91	278	44	-	-	HYPH
cord-015910-d9gxew91	278	45	a	a	NN
cord-015910-d9gxew91	278	46	.	.	.
cord-015910-d9gxew91	279	1	However	however	RB
cord-015910-d9gxew91	279	2	,	,	,
cord-015910-d9gxew91	279	3	individuals	individual	NNS
cord-015910-d9gxew91	279	4	with	with	IN
cord-015910-d9gxew91	279	5	the	the	DT
cord-015910-d9gxew91	279	6	LT	LT	NNP
cord-015910-d9gxew91	279	7	-	-	HYPH
cord-015910-d9gxew91	279	8	c~+	c~+	NNP
cord-015910-d9gxew91	279	9	252	252	CD
cord-015910-d9gxew91	279	10	AA	AA	NNP
cord-015910-d9gxew91	279	11	genotype	genotype	NN
cord-015910-d9gxew91	279	12	(	(	-LRB-
cord-015910-d9gxew91	279	13	associated	associate	VBN
cord-015910-d9gxew91	279	14	with	with	IN
cord-015910-d9gxew91	279	15	raised	raise	VBN
cord-015910-d9gxew91	279	16	TNF	TNF	NNP
cord-015910-d9gxew91	279	17	production	production	NN
cord-015910-d9gxew91	279	18	)	)	-RRB-
cord-015910-d9gxew91	279	19	showed	show	VBD
cord-015910-d9gxew91	279	20	significant	significant	JJ
cord-015910-d9gxew91	279	21	relationships	relationship	NNS
cord-015910-d9gxew91	279	22	between	between	IN
cord-015910-d9gxew91	279	23	TNF	tnf	NN
cord-015910-d9gxew91	279	24	production	production	NN
cord-015910-d9gxew91	279	25	and	and	CC
cord-015910-d9gxew91	279	26	BMI	BMI	NNP
cord-015910-d9gxew91	279	27	and	and	CC
cord-015910-d9gxew91	279	28	fasting	fast	VBG
cord-015910-d9gxew91	279	29	triglycerldes	triglycerlde	NNS
cord-015910-d9gxew91	279	30	(	(	-LRB-
cord-015910-d9gxew91	279	31	Fig	Fig	NNP
cord-015910-d9gxew91	279	32	.	.	NNP
cord-015910-d9gxew91	279	33	7	7	CD
cord-015910-d9gxew91	279	34	)	)	-RRB-
cord-015910-d9gxew91	279	35	.	.	.
cord-015910-d9gxew91	280	1	Thus	thus	RB
cord-015910-d9gxew91	280	2	,	,	,
cord-015910-d9gxew91	280	3	despite	despite	IN
cord-015910-d9gxew91	280	4	the	the	DT
cord-015910-d9gxew91	280	5	study	study	NN
cord-015910-d9gxew91	280	6	population	population	NN
cord-015910-d9gxew91	280	7	being	be	VBG
cord-015910-d9gxew91	280	8	comprised	comprise	VBN
cord-015910-d9gxew91	280	9	of	of	IN
cord-015910-d9gxew91	280	10	healthy	healthy	JJ
cord-015910-d9gxew91	280	11	subjects	subject	NNS
cord-015910-d9gxew91	280	12	,	,	,
cord-015910-d9gxew91	280	13	within	within	IN
cord-015910-d9gxew91	280	14	that	that	DT
cord-015910-d9gxew91	280	15	population	population	NN
cord-015910-d9gxew91	280	16	were	be	VBD
cord-015910-d9gxew91	280	17	individuals	individual	NNS
cord-015910-d9gxew91	280	18	with	with	IN
cord-015910-d9gxew91	280	19	a	a	DT
cord-015910-d9gxew91	280	20	genotype	genotype	NN
cord-015910-d9gxew91	280	21	that	that	WDT
cord-015910-d9gxew91	280	22	resulted	result	VBD
cord-015910-d9gxew91	280	23	in	in	IN
cord-015910-d9gxew91	280	24	an	an	DT
cord-015910-d9gxew91	280	25	"	"	``
cord-015910-d9gxew91	280	26	aged	aged	JJ
cord-015910-d9gxew91	280	27	"	"	''
cord-015910-d9gxew91	280	28	phenotype	phenotype	NN
cord-015910-d9gxew91	280	29	as	as	RB
cord-015910-d9gxew91	280	30	far	far	RB
cord-015910-d9gxew91	280	31	as	as	IN
cord-015910-d9gxew91	280	32	plasma	plasma	NN
cord-015910-d9gxew91	280	33	lipids	lipid	NNS
cord-015910-d9gxew91	280	34	,	,	,
cord-015910-d9gxew91	280	35	BMI	BMI	NNP
cord-015910-d9gxew91	280	36	,	,	,
cord-015910-d9gxew91	280	37	and	and	CC
cord-015910-d9gxew91	280	38	inflammation	inflammation	NN
cord-015910-d9gxew91	280	39	were	be	VBD
cord-015910-d9gxew91	280	40	concerned	concern	VBN
cord-015910-d9gxew91	281	1	(	(	-LRB-
cord-015910-d9gxew91	281	2	Paolini	Paolini	NNP
cord-015910-d9gxew91	281	3	-	-	HYPH
cord-015910-d9gxew91	281	4	Giacobino	Giacobino	NNP
cord-015910-d9gxew91	281	5	et	et	FW
cord-015910-d9gxew91	281	6	al	al	NNP
cord-015910-d9gxew91	281	7	.	.	NNP
cord-015910-d9gxew91	281	8	,	,	,
cord-015910-d9gxew91	281	9	2003	2003	CD
cord-015910-d9gxew91	281	10	)	)	-RRB-
cord-015910-d9gxew91	281	11	.	.	.
cord-015910-d9gxew91	282	1	It	-PRON-	PRP
cord-015910-d9gxew91	282	2	is	be	VBZ
cord-015910-d9gxew91	282	3	well	well	RB
cord-015910-d9gxew91	282	4	known	know	VBN
cord-015910-d9gxew91	282	5	that	that	IN
cord-015910-d9gxew91	282	6	the	the	DT
cord-015910-d9gxew91	282	7	incidence	incidence	NN
cord-015910-d9gxew91	282	8	of	of	IN
cord-015910-d9gxew91	282	9	diseases	disease	NNS
cord-015910-d9gxew91	282	10	of	of	IN
cord-015910-d9gxew91	282	11	affluence	affluence	NN
cord-015910-d9gxew91	282	12	and	and	CC
cord-015910-d9gxew91	282	13	recognizable	recognizable	JJ
cord-015910-d9gxew91	282	14	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	282	15	diseases	disease	NNS
cord-015910-d9gxew91	282	16	,	,	,
cord-015910-d9gxew91	282	17	such	such	JJ
cord-015910-d9gxew91	282	18	as	as	IN
cord-015910-d9gxew91	282	19	rheumatoid	rheumatoid	JJ
cord-015910-d9gxew91	282	20	arthritis	arthritis	NN
cord-015910-d9gxew91	282	21	,	,	,
cord-015910-d9gxew91	282	22	increase	increase	VB
cord-015910-d9gxew91	282	23	with	with	IN
cord-015910-d9gxew91	282	24	aging	aging	NN
cord-015910-d9gxew91	282	25	.	.	.
cord-015910-d9gxew91	283	1	Are	be	VBP
cord-015910-d9gxew91	283	2	these	these	DT
cord-015910-d9gxew91	283	3	phenomena	phenomenon	NNS
cord-015910-d9gxew91	283	4	an	an	DT
cord-015910-d9gxew91	283	5	unfortunate	unfortunate	JJ
cord-015910-d9gxew91	283	6	side	side	NN
cord-015910-d9gxew91	283	7	effect	effect	NN
cord-015910-d9gxew91	283	8	of	of	IN
cord-015910-d9gxew91	283	9	maturity	maturity	NN
cord-015910-d9gxew91	283	10	,	,	,
cord-015910-d9gxew91	283	11	or	or	CC
cord-015910-d9gxew91	283	12	is	be	VBZ
cord-015910-d9gxew91	283	13	there	there	EX
cord-015910-d9gxew91	283	14	a	a	DT
cord-015910-d9gxew91	283	15	common	common	JJ
cord-015910-d9gxew91	283	16	mechanism	mechanism	NN
cord-015910-d9gxew91	283	17	that	that	WDT
cord-015910-d9gxew91	283	18	determines	determine	VBZ
cord-015910-d9gxew91	283	19	the	the	DT
cord-015910-d9gxew91	283	20	appearance	appearance	NN
cord-015910-d9gxew91	283	21	of	of	IN
cord-015910-d9gxew91	283	22	these	these	DT
cord-015910-d9gxew91	283	23	diseases	disease	NNS
cord-015910-d9gxew91	283	24	patterns	pattern	NNS
cord-015910-d9gxew91	283	25	in	in	IN
cord-015910-d9gxew91	283	26	the	the	DT
cord-015910-d9gxew91	283	27	elderly	elderly	JJ
cord-015910-d9gxew91	283	28	.	.	.
cord-015910-d9gxew91	283	29	'	'	''
cord-015910-d9gxew91	283	30	?	?	.
cord-015910-d9gxew91	284	1	Paradoxically	paradoxically	RB
cord-015910-d9gxew91	284	2	,	,	,
cord-015910-d9gxew91	284	3	aging	age	VBG
cord-015910-d9gxew91	284	4	is	be	VBZ
cord-015910-d9gxew91	284	5	associated	associate	VBN
cord-015910-d9gxew91	284	6	with	with	IN
cord-015910-d9gxew91	284	7	a	a	DT
cord-015910-d9gxew91	284	8	decline	decline	NN
cord-015910-d9gxew91	284	9	in	in	IN
cord-015910-d9gxew91	284	10	T	t	NN
cord-015910-d9gxew91	284	11	-	-	HYPH
cord-015910-d9gxew91	284	12	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	284	13	function	function	NN
cord-015910-d9gxew91	284	14	and	and	CC
cord-015910-d9gxew91	284	15	an	an	DT
cord-015910-d9gxew91	284	16	increase	increase	NN
cord-015910-d9gxew91	284	17	in	in	IN
cord-015910-d9gxew91	284	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	284	19	stress	stress	NN
cord-015910-d9gxew91	284	20	.	.	.
cord-015910-d9gxew91	285	1	A	a	DT
cord-015910-d9gxew91	285	2	number	number	NN
cord-015910-d9gxew91	285	3	of	of	IN
cord-015910-d9gxew91	285	4	elements	element	NNS
cord-015910-d9gxew91	285	5	of	of	IN
cord-015910-d9gxew91	285	6	the	the	DT
cord-015910-d9gxew91	285	7	chronic	chronic	JJ
cord-015910-d9gxew91	285	8	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	285	9	response	response	NN
cord-015910-d9gxew91	285	10	are	be	VBP
cord-015910-d9gxew91	285	11	apparent	apparent	JJ
cord-015910-d9gxew91	285	12	in	in	IN
cord-015910-d9gxew91	285	13	otherwise	otherwise	RB
cord-015910-d9gxew91	285	14	healthy	healthy	JJ
cord-015910-d9gxew91	285	15	elderly	elderly	JJ
cord-015910-d9gxew91	285	16	subjects	subject	NNS
cord-015910-d9gxew91	285	17	.	.	.
cord-015910-d9gxew91	286	1	The	the	DT
cord-015910-d9gxew91	286	2	elements	element	NNS
cord-015910-d9gxew91	286	3	of	of	IN
cord-015910-d9gxew91	286	4	the	the	DT
cord-015910-d9gxew91	286	5	response	response	NN
cord-015910-d9gxew91	286	6	include	include	VBP
cord-015910-d9gxew91	286	7	muscle	muscle	NN
cord-015910-d9gxew91	286	8	protein	protein	NN
cord-015910-d9gxew91	286	9	loss	loss	NN
cord-015910-d9gxew91	286	10	,	,	,
cord-015910-d9gxew91	286	11	a	a	DT
cord-015910-d9gxew91	286	12	rise	rise	NN
cord-015910-d9gxew91	286	13	in	in	IN
cord-015910-d9gxew91	286	14	plasma	plasma	NN
cord-015910-d9gxew91	286	15	acute	acute	JJ
cord-015910-d9gxew91	286	16	-	-	HYPH
cord-015910-d9gxew91	286	17	phase	phase	NN
cord-015910-d9gxew91	286	18	protein	protein	NN
cord-015910-d9gxew91	286	19	concentrations	concentration	NNS
cord-015910-d9gxew91	286	20	,	,	,
cord-015910-d9gxew91	286	21	and	and	CC
cord-015910-d9gxew91	286	22	a	a	DT
cord-015910-d9gxew91	286	23	decrease	decrease	NN
cord-015910-d9gxew91	286	24	in	in	IN
cord-015910-d9gxew91	286	25	plasma	plasma	NN
cord-015910-d9gxew91	286	26	zinc	zinc	NN
cord-015910-d9gxew91	286	27	.	.	.
cord-015910-d9gxew91	287	1	An	an	DT
cord-015910-d9gxew91	287	2	age	age	NN
cord-015910-d9gxew91	287	3	-	-	HYPH
cord-015910-d9gxew91	287	4	related	relate	VBN
cord-015910-d9gxew91	287	5	increase	increase	NN
cord-015910-d9gxew91	287	6	in	in	IN
cord-015910-d9gxew91	287	7	IL-6	IL-6	NNP
cord-015910-d9gxew91	287	8	concentration	concentration	NN
cord-015910-d9gxew91	287	9	has	have	VBZ
cord-015910-d9gxew91	287	10	been	be	VBN
cord-015910-d9gxew91	287	11	found	find	VBN
cord-015910-d9gxew91	287	12	in	in	IN
cord-015910-d9gxew91	287	13	serum	serum	NN
cord-015910-d9gxew91	287	14	,	,	,
cord-015910-d9gxew91	287	15	plasma	plasma	NN
cord-015910-d9gxew91	287	16	,	,	,
cord-015910-d9gxew91	287	17	and	and	CC
cord-015910-d9gxew91	287	18	supernatants	supernatant	NNS
cord-015910-d9gxew91	287	19	of	of	IN
cord-015910-d9gxew91	287	20	mononuclear	mononuclear	JJ
cord-015910-d9gxew91	287	21	blood	blood	NN
cord-015910-d9gxew91	287	22	cell	cell	NN
cord-015910-d9gxew91	287	23	cultures	culture	NNS
cord-015910-d9gxew91	287	24	from	from	IN
cord-015910-d9gxew91	287	25	apparently	apparently	RB
cord-015910-d9gxew91	287	26	healthy	healthy	JJ
cord-015910-d9gxew91	287	27	elderly	elderly	JJ
cord-015910-d9gxew91	287	28	people	people	NNS
cord-015910-d9gxew91	287	29	and	and	CC
cord-015910-d9gxew91	287	30	centenarians	centenarian	NNS
cord-015910-d9gxew91	287	31	(	(	-LRB-
cord-015910-d9gxew91	287	32	Fagiolo	Fagiolo	NNP
cord-015910-d9gxew91	287	33	et	et	NNP
cord-015910-d9gxew91	287	34	al	al	NNP
cord-015910-d9gxew91	287	35	.	.	NNP
cord-015910-d9gxew91	287	36	,	,	,
cord-015910-d9gxew91	287	37	1993	1993	CD
cord-015910-d9gxew91	287	38	;	;	:
cord-015910-d9gxew91	287	39	Baggio	Baggio	NNP
cord-015910-d9gxew91	287	40	,	,	,
cord-015910-d9gxew91	287	41	Donnazzan	Donnazzan	NNP
cord-015910-d9gxew91	287	42	,	,	,
cord-015910-d9gxew91	287	43	Monti	Monti	NNP
cord-015910-d9gxew91	287	44	,	,	,
cord-015910-d9gxew91	287	45	&	&	CC
cord-015910-d9gxew91	287	46	Marl	Marl	NNP
cord-015910-d9gxew91	287	47	,	,	,
cord-015910-d9gxew91	287	48	1998	1998	CD
cord-015910-d9gxew91	287	49	;	;	:
cord-015910-d9gxew91	287	50	Ershler	Ershler	NNP
cord-015910-d9gxew91	287	51	&	&	CC
cord-015910-d9gxew91	287	52	Kerller	Kerller	NNP
cord-015910-d9gxew91	287	53	,	,	,
cord-015910-d9gxew91	287	54	2000	2000	CD
cord-015910-d9gxew91	287	55	)	)	-RRB-
cord-015910-d9gxew91	287	56	.	.	.
cord-015910-d9gxew91	288	1	Because	because	IN
cord-015910-d9gxew91	288	2	IL-6	IL-6	NNP
cord-015910-d9gxew91	288	3	is	be	VBZ
cord-015910-d9gxew91	288	4	a	a	DT
cord-015910-d9gxew91	288	5	pleiotropic	pleiotropic	JJ
cord-015910-d9gxew91	288	6	cytokine	cytokine	NN
cord-015910-d9gxew91	288	7	capable	capable	JJ
cord-015910-d9gxew91	288	8	of	of	IN
cord-015910-d9gxew91	288	9	regulating	regulate	VBG
cord-015910-d9gxew91	288	10	proliferation	proliferation	NN
cord-015910-d9gxew91	288	11	,	,	,
cord-015910-d9gxew91	288	12	differentiation	differentiation	NN
cord-015910-d9gxew91	288	13	,	,	,
cord-015910-d9gxew91	288	14	and	and	CC
cord-015910-d9gxew91	288	15	activity	activity	NN
cord-015910-d9gxew91	288	16	of	of	IN
cord-015910-d9gxew91	288	17	a	a	DT
cord-015910-d9gxew91	288	18	variety	variety	NN
cord-015910-d9gxew91	288	19	of	of	IN
cord-015910-d9gxew91	288	20	cell	cell	NN
cord-015910-d9gxew91	288	21	types	type	NNS
cord-015910-d9gxew91	288	22	(	(	-LRB-
cord-015910-d9gxew91	288	23	Ershler	Ershler	NNP
cord-015910-d9gxew91	288	24	&	&	CC
cord-015910-d9gxew91	288	25	Kerller	Kerller	NNP
cord-015910-d9gxew91	288	26	,	,	,
cord-015910-d9gxew91	288	27	2000	2000	CD
cord-015910-d9gxew91	288	28	)	)	-RRB-
cord-015910-d9gxew91	288	29	and	and	CC
cord-015910-d9gxew91	288	30	plays	play	VBZ
cord-015910-d9gxew91	288	31	a	a	DT
cord-015910-d9gxew91	288	32	pivotal	pivotal	JJ
cord-015910-d9gxew91	288	33	role	role	NN
cord-015910-d9gxew91	288	34	in	in	IN
cord-015910-d9gxew91	288	35	neuroendocrlne	neuroendocrlne	NNP
cord-015910-d9gxew91	288	36	and	and	CC
cord-015910-d9gxew91	288	37	immune	immune	JJ
cord-015910-d9gxew91	288	38	system	system	NN
cord-015910-d9gxew91	288	39	homeostasis	homeostasis	NN
cord-015910-d9gxew91	288	40	,	,	,
cord-015910-d9gxew91	288	41	it	-PRON-	PRP
cord-015910-d9gxew91	288	42	is	be	VBZ
cord-015910-d9gxew91	288	43	not	not	RB
cord-015910-d9gxew91	288	44	surprising	surprising	JJ
cord-015910-d9gxew91	288	45	that	that	IN
cord-015910-d9gxew91	288	46	the	the	DT
cord-015910-d9gxew91	288	47	rise	rise	NN
cord-015910-d9gxew91	288	48	in	in	IN
cord-015910-d9gxew91	288	49	production	production	NN
cord-015910-d9gxew91	288	50	of	of	IN
cord-015910-d9gxew91	288	51	pro	pro	JJ
cord-015910-d9gxew91	288	52	-	-	JJ
cord-015910-d9gxew91	288	53	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	288	54	cytokines	cytokine	NNS
cord-015910-d9gxew91	288	55	might	may	MD
cord-015910-d9gxew91	288	56	have	have	VB
cord-015910-d9gxew91	288	57	long	long	JJ
cord-015910-d9gxew91	288	58	-	-	HYPH
cord-015910-d9gxew91	288	59	term	term	NN
cord-015910-d9gxew91	288	60	pathological	pathological	JJ
cord-015910-d9gxew91	288	61	effects	effect	NNS
cord-015910-d9gxew91	288	62	(	(	-LRB-
cord-015910-d9gxew91	288	63	Bethin	Bethin	NNP
cord-015910-d9gxew91	288	64	,	,	,
cord-015910-d9gxew91	288	65	Vogt	Vogt	NNP
cord-015910-d9gxew91	288	66	,	,	,
cord-015910-d9gxew91	288	67	&	&	CC
cord-015910-d9gxew91	288	68	Muglia	Muglia	NNP
cord-015910-d9gxew91	288	69	,	,	,
cord-015910-d9gxew91	288	70	2000	2000	CD
cord-015910-d9gxew91	289	1	Fasting	fast	VBG
cord-015910-d9gxew91	289	2	triglycerides	triglyceride	NNS
cord-015910-d9gxew91	289	3	Fig	Fig	NNP
cord-015910-d9gxew91	289	4	.	.	.
cord-015910-d9gxew91	290	1	7	7	CD
cord-015910-d9gxew91	290	2	.	.	.
cord-015910-d9gxew91	291	1	Relationships	relationship	NNS
cord-015910-d9gxew91	291	2	between	between	IN
cord-015910-d9gxew91	291	3	TNF	TNF	NNP
cord-015910-d9gxew91	291	4	production	production	NN
cord-015910-d9gxew91	291	5	,	,	,
cord-015910-d9gxew91	291	6	BMI	BMI	NNP
cord-015910-d9gxew91	291	7	and	and	CC
cord-015910-d9gxew91	291	8	fasting	fast	VBG
cord-015910-d9gxew91	291	9	triglycerides	triglyceride	NNS
cord-015910-d9gxew91	291	10	,	,	,
cord-015910-d9gxew91	291	11	and	and	CC
cord-015910-d9gxew91	291	12	the	the	DT
cord-015910-d9gxew91	291	13	ability	ability	NN
cord-015910-d9gxew91	291	14	of	of	IN
cord-015910-d9gxew91	291	15	PBMCs	pbmc	NNS
cord-015910-d9gxew91	291	16	to	to	TO
cord-015910-d9gxew91	291	17	produce	produce	VB
cord-015910-d9gxew91	291	18	TNF	TNF	NNP
cord-015910-d9gxew91	291	19	-	-	HYPH
cord-015910-d9gxew91	291	20	o~	o~	NNP
cord-015910-d9gxew91	291	21	in	in	IN
cord-015910-d9gxew91	291	22	the	the	DT
cord-015910-d9gxew91	291	23	study	study	NN
cord-015910-d9gxew91	291	24	populations	population	NNS
cord-015910-d9gxew91	291	25	:	:	:
cord-015910-d9gxew91	291	26	(	(	-LRB-
cord-015910-d9gxew91	291	27	A	a	NN
cord-015910-d9gxew91	291	28	)	)	-RRB-
cord-015910-d9gxew91	291	29	all	all	DT
cord-015910-d9gxew91	291	30	subjects	subject	NNS
cord-015910-d9gxew91	291	31	irrespective	irrespective	RB
cord-015910-d9gxew91	291	32	of	of	IN
cord-015910-d9gxew91	291	33	genotype	genotype	NN
cord-015910-d9gxew91	291	34	,	,	,
cord-015910-d9gxew91	291	35	(	(	-LRB-
cord-015910-d9gxew91	291	36	B	b	NN
cord-015910-d9gxew91	291	37	)	)	-RRB-
cord-015910-d9gxew91	291	38	individuals	individual	NNS
cord-015910-d9gxew91	291	39	with	with	IN
cord-015910-d9gxew91	291	40	the	the	DT
cord-015910-d9gxew91	291	41	LT	LT	NNP
cord-015910-d9gxew91	291	42	-	-	HYPH
cord-015910-d9gxew91	291	43	ct+	ct+	NNP
cord-015910-d9gxew91	291	44	252	252	CD
cord-015910-d9gxew91	291	45	AA	AA	NNP
cord-015910-d9gxew91	291	46	genotype	genotype	NN
cord-015910-d9gxew91	291	47	,	,	,
cord-015910-d9gxew91	291	48	associated	associate	VBN
cord-015910-d9gxew91	291	49	with	with	IN
cord-015910-d9gxew91	291	50	raised	raise	VBN
cord-015910-d9gxew91	291	51	TNF	TNF	NNP
cord-015910-d9gxew91	291	52	production	production	NN
cord-015910-d9gxew91	291	53	.	.	.
cord-015910-d9gxew91	292	1	NS	NS	NNP
cord-015910-d9gxew91	292	2	,	,	,
cord-015910-d9gxew91	292	3	nonsignificant	nonsignificant	JJ
cord-015910-d9gxew91	292	4	relationship	relationship	NN
cord-015910-d9gxew91	292	5	;	;	:
cord-015910-d9gxew91	292	6	BMI	BMI	NNP
cord-015910-d9gxew91	292	7	,	,	,
cord-015910-d9gxew91	292	8	body	body	NN
cord-015910-d9gxew91	292	9	mass	mass	NN
cord-015910-d9gxew91	292	10	index	index	NN
cord-015910-d9gxew91	292	11	;	;	:
cord-015910-d9gxew91	292	12	PBMCs	pbmc	NNS
cord-015910-d9gxew91	292	13	,	,	,
cord-015910-d9gxew91	292	14	peripheral	peripheral	JJ
cord-015910-d9gxew91	292	15	blood	blood	NN
cord-015910-d9gxew91	292	16	mononuclear	mononuclear	NN
cord-015910-d9gxew91	292	17	cells	cell	NNS
cord-015910-d9gxew91	292	18	.	.	.
cord-015910-d9gxew91	293	1	The	the	DT
cord-015910-d9gxew91	293	2	number	number	NN
cord-015910-d9gxew91	293	3	of	of	IN
cord-015910-d9gxew91	293	4	subjects	subject	NNS
cord-015910-d9gxew91	293	5	is	be	VBZ
cord-015910-d9gxew91	293	6	shown	show	VBN
cord-015910-d9gxew91	293	7	in	in	IN
cord-015910-d9gxew91	293	8	parentheses	parenthesis	NNS
cord-015910-d9gxew91	293	9	;	;	:
cord-015910-d9gxew91	293	10	the	the	DT
cord-015910-d9gxew91	293	11	correlations	correlation	NNS
cord-015910-d9gxew91	293	12	were	be	VBD
cord-015910-d9gxew91	293	13	examined	examine	VBN
cord-015910-d9gxew91	293	14	by	by	IN
cord-015910-d9gxew91	293	15	Spearman	Spearman	NNP
cord-015910-d9gxew91	293	16	'	'	POS
cord-015910-d9gxew91	293	17	s	s	POS
cord-015910-d9gxew91	293	18	rank	rank	NN
cord-015910-d9gxew91	293	19	correlation	correlation	NN
cord-015910-d9gxew91	293	20	.	.	.
cord-015910-d9gxew91	294	1	levels	level	NNS
cord-015910-d9gxew91	294	2	of	of	IN
cord-015910-d9gxew91	294	3	this	this	DT
cord-015910-d9gxew91	294	4	cytokine	cytokine	NN
cord-015910-d9gxew91	294	5	have	have	VBP
cord-015910-d9gxew91	294	6	also	also	RB
cord-015910-d9gxew91	294	7	been	be	VBN
cord-015910-d9gxew91	294	8	found	find	VBN
cord-015910-d9gxew91	294	9	as	as	RB
cord-015910-d9gxew91	294	10	early	early	RB
cord-015910-d9gxew91	294	11	as	as	IN
cord-015910-d9gxew91	294	12	at	at	IN
cord-015910-d9gxew91	294	13	30	30	CD
cord-015910-d9gxew91	294	14	-	-	SYM
cord-015910-d9gxew91	294	15	40	40	CD
cord-015910-d9gxew91	294	16	yr	yr	NN
cord-015910-d9gxew91	294	17	of	of	IN
cord-015910-d9gxew91	294	18	age	age	NN
cord-015910-d9gxew91	294	19	(	(	-LRB-
cord-015910-d9gxew91	294	20	Mysliwska	Mysliwska	NNP
cord-015910-d9gxew91	294	21	,	,	,
cord-015910-d9gxew91	294	22	Bryl	Bryl	NNP
cord-015910-d9gxew91	294	23	,	,	,
cord-015910-d9gxew91	294	24	Foerster	Foerster	NNP
cord-015910-d9gxew91	294	25	,	,	,
cord-015910-d9gxew91	294	26	&	&	CC
cord-015910-d9gxew91	294	27	Mysliwski	Mysliwski	NNP
cord-015910-d9gxew91	294	28	,	,	,
cord-015910-d9gxew91	294	29	1998	1998	CD
cord-015910-d9gxew91	294	30	)	)	-RRB-
cord-015910-d9gxew91	294	31	,	,	,
cord-015910-d9gxew91	294	32	particularly	particularly	RB
cord-015910-d9gxew91	294	33	in	in	IN
cord-015910-d9gxew91	294	34	men	man	NNS
cord-015910-d9gxew91	294	35	(	(	-LRB-
cord-015910-d9gxew91	294	36	Young	Young	NNP
cord-015910-d9gxew91	294	37	,	,	,
cord-015910-d9gxew91	294	38	Skibinski	Skibinski	NNP
cord-015910-d9gxew91	294	39	,	,	,
cord-015910-d9gxew91	294	40	Mason	Mason	NNP
cord-015910-d9gxew91	294	41	,	,	,
cord-015910-d9gxew91	294	42	&	&	CC
cord-015910-d9gxew91	294	43	James	James	NNP
cord-015910-d9gxew91	294	44	,	,	,
cord-015910-d9gxew91	294	45	1999	1999	CD
cord-015910-d9gxew91	294	46	)	)	-RRB-
cord-015910-d9gxew91	294	47	.	.	.
cord-015910-d9gxew91	295	1	Population	population	NN
cord-015910-d9gxew91	295	2	studies	study	NNS
cord-015910-d9gxew91	295	3	have	have	VBP
cord-015910-d9gxew91	295	4	shown	show	VBN
cord-015910-d9gxew91	295	5	that	that	IN
cord-015910-d9gxew91	295	6	the	the	DT
cord-015910-d9gxew91	295	7	magnitude	magnitude	NN
cord-015910-d9gxew91	295	8	of	of	IN
cord-015910-d9gxew91	295	9	increase	increase	NN
cord-015910-d9gxew91	295	10	in	in	IN
cord-015910-d9gxew91	295	11	the	the	DT
cord-015910-d9gxew91	295	12	concentration	concentration	NN
cord-015910-d9gxew91	295	13	of	of	IN
cord-015910-d9gxew91	295	14	IL-6	IL-6	NNP
cord-015910-d9gxew91	295	15	is	be	VBZ
cord-015910-d9gxew91	295	16	a	a	DT
cord-015910-d9gxew91	295	17	reliable	reliable	JJ
cord-015910-d9gxew91	295	18	marker	marker	NN
cord-015910-d9gxew91	295	19	for	for	IN
cord-015910-d9gxew91	295	20	functional	functional	JJ
cord-015910-d9gxew91	295	21	disability	disability	NN
cord-015910-d9gxew91	295	22	and	and	CC
cord-015910-d9gxew91	295	23	a	a	DT
cord-015910-d9gxew91	295	24	predictor	predictor	NN
cord-015910-d9gxew91	295	25	of	of	IN
cord-015910-d9gxew91	295	26	mortality	mortality	NN
cord-015910-d9gxew91	295	27	in	in	IN
cord-015910-d9gxew91	295	28	the	the	DT
cord-015910-d9gxew91	295	29	elderly	elderly	JJ
cord-015910-d9gxew91	296	1	(	(	-LRB-
cord-015910-d9gxew91	296	2	Ferrucci	Ferrucci	NNP
cord-015910-d9gxew91	296	3	,	,	,
cord-015910-d9gxew91	296	4	Harris	Harris	NNP
cord-015910-d9gxew91	296	5	,	,	,
cord-015910-d9gxew91	296	6	Guralnik	Guralnik	NNP
cord-015910-d9gxew91	296	7	,	,	,
cord-015910-d9gxew91	296	8	&	&	CC
cord-015910-d9gxew91	296	9	Tracy	Tracy	NNP
cord-015910-d9gxew91	296	10	,	,	,
cord-015910-d9gxew91	296	11	1999	1999	CD
cord-015910-d9gxew91	296	12	;	;	:
cord-015910-d9gxew91	296	13	Harris	Harris	NNP
cord-015910-d9gxew91	296	14	,	,	,
cord-015910-d9gxew91	296	15	Ferrucci	Ferrucci	NNP
cord-015910-d9gxew91	296	16	,	,	,
cord-015910-d9gxew91	296	17	Tracy	Tracy	NNP
cord-015910-d9gxew91	296	18	,	,	,
cord-015910-d9gxew91	296	19	&	&	CC
cord-015910-d9gxew91	296	20	Corti	Corti	NNP
cord-015910-d9gxew91	296	21	,	,	,
cord-015910-d9gxew91	296	22	1999	1999	CD
cord-015910-d9gxew91	296	23	)	)	-RRB-
cord-015910-d9gxew91	296	24	.	.	.
cord-015910-d9gxew91	297	1	Antioxidant	antioxidant	JJ
cord-015910-d9gxew91	297	2	status	status	NN
cord-015910-d9gxew91	297	3	may	may	MD
cord-015910-d9gxew91	297	4	decline	decline	VB
cord-015910-d9gxew91	297	5	with	with	IN
cord-015910-d9gxew91	297	6	age	age	NN
cord-015910-d9gxew91	297	7	(	(	-LRB-
cord-015910-d9gxew91	297	8	Nuttall	Nuttall	NNP
cord-015910-d9gxew91	297	9	,	,	,
cord-015910-d9gxew91	297	10	Dunne	Dunne	NNP
cord-015910-d9gxew91	297	11	,	,	,
cord-015910-d9gxew91	297	12	Kendall	Kendall	NNP
cord-015910-d9gxew91	297	13	,	,	,
cord-015910-d9gxew91	297	14	&	&	CC
cord-015910-d9gxew91	297	15	Martin	Martin	NNP
cord-015910-d9gxew91	297	16	,	,	,
cord-015910-d9gxew91	297	17	1999	1999	CD
cord-015910-d9gxew91	297	18	)	)	-RRB-
cord-015910-d9gxew91	297	19	and	and	CC
cord-015910-d9gxew91	297	20	may	may	MD
cord-015910-d9gxew91	297	21	thus	thus	RB
cord-015910-d9gxew91	297	22	be	be	VB
cord-015910-d9gxew91	297	23	linked	link	VBN
cord-015910-d9gxew91	297	24	to	to	IN
cord-015910-d9gxew91	297	25	increased	increase	VBN
cord-015910-d9gxew91	297	26	TNF-~	TNF-~	NNP
cord-015910-d9gxew91	297	27	production	production	NN
cord-015910-d9gxew91	297	28	(	(	-LRB-
cord-015910-d9gxew91	297	29	Kudoh	Kudoh	NNP
cord-015910-d9gxew91	297	30	,	,	,
cord-015910-d9gxew91	297	31	Katagai	Katagai	NNP
cord-015910-d9gxew91	297	32	,	,	,
cord-015910-d9gxew91	297	33	Takazawa	Takazawa	NNP
cord-015910-d9gxew91	297	34	,	,	,
cord-015910-d9gxew91	297	35	&	&	CC
cord-015910-d9gxew91	297	36	Matsuki	Matsuki	NNP
cord-015910-d9gxew91	297	37	,	,	,
cord-015910-d9gxew91	297	38	2001	2001	CD
cord-015910-d9gxew91	297	39	;	;	:
cord-015910-d9gxew91	297	40	Rink	Rink	NNP
cord-015910-d9gxew91	297	41	,	,	,
cord-015910-d9gxew91	297	42	Cakman	Cakman	NNP
cord-015910-d9gxew91	297	43	,	,	,
cord-015910-d9gxew91	297	44	&	&	CC
cord-015910-d9gxew91	297	45	Kirchner	Kirchner	NNP
cord-015910-d9gxew91	297	46	,	,	,
cord-015910-d9gxew91	297	47	1998	1998	CD
cord-015910-d9gxew91	297	48	)	)	-RRB-
cord-015910-d9gxew91	297	49	.	.	.
cord-015910-d9gxew91	298	1	An	an	DT
cord-015910-d9gxew91	298	2	enhanced	enhanced	JJ
cord-015910-d9gxew91	298	3	capacity	capacity	NN
cord-015910-d9gxew91	298	4	for	for	IN
cord-015910-d9gxew91	298	5	the	the	DT
cord-015910-d9gxew91	298	6	release	release	NN
cord-015910-d9gxew91	298	7	of	of	IN
cord-015910-d9gxew91	298	8	pro	pro	JJ
cord-015910-d9gxew91	298	9	-	-	JJ
cord-015910-d9gxew91	298	10	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	298	11	cytokines	cytokine	NNS
cord-015910-d9gxew91	298	12	by	by	IN
cord-015910-d9gxew91	298	13	white	white	JJ
cord-015910-d9gxew91	298	14	blood	blood	NN
cord-015910-d9gxew91	298	15	cells	cell	NNS
cord-015910-d9gxew91	298	16	may	may	MD
cord-015910-d9gxew91	298	17	contribute	contribute	VB
cord-015910-d9gxew91	298	18	to	to	IN
cord-015910-d9gxew91	298	19	the	the	DT
cord-015910-d9gxew91	298	20	pathogenesis	pathogenesis	NN
cord-015910-d9gxew91	298	21	of	of	IN
cord-015910-d9gxew91	298	22	ischemic	ischemic	JJ
cord-015910-d9gxew91	298	23	stroke	stroke	NN
cord-015910-d9gxew91	298	24	.	.	.
cord-015910-d9gxew91	299	1	Grau	Grau	NNP
cord-015910-d9gxew91	299	2	et	et	NNP
cord-015910-d9gxew91	299	3	al	al	NNP
cord-015910-d9gxew91	299	4	.	.	.
cord-015910-d9gxew91	300	1	(	(	-LRB-
cord-015910-d9gxew91	300	2	2001	2001	CD
cord-015910-d9gxew91	300	3	)	)	-RRB-
cord-015910-d9gxew91	300	4	investigated	investigate	VBD
cord-015910-d9gxew91	300	5	the	the	DT
cord-015910-d9gxew91	300	6	LPS	LPS	NNP
cord-015910-d9gxew91	300	7	-	-	HYPH
cord-015910-d9gxew91	300	8	induced	induce	VBN
cord-015910-d9gxew91	300	9	release	release	NN
cord-015910-d9gxew91	300	10	of	of	IN
cord-015910-d9gxew91	300	11	IL-1	IL-1	NNP
cord-015910-d9gxew91	300	12	[	[	-LRB-
cord-015910-d9gxew91	300	13	3	3	CD
cord-015910-d9gxew91	300	14	,	,	,
cord-015910-d9gxew91	300	15	IL-6	IL-6	NNP
cord-015910-d9gxew91	300	16	,	,	,
cord-015910-d9gxew91	300	17	IL-8	IL-8	NNP
cord-015910-d9gxew91	300	18	,	,	,
cord-015910-d9gxew91	300	19	and	and	CC
cord-015910-d9gxew91	300	20	TNF-0~	tnf-0~	NN
cord-015910-d9gxew91	300	21	in	in	IN
cord-015910-d9gxew91	300	22	whole	whole	JJ
cord-015910-d9gxew91	300	23	blood	blood	NN
cord-015910-d9gxew91	300	24	from	from	IN
cord-015910-d9gxew91	300	25	patients	patient	NNS
cord-015910-d9gxew91	300	26	with	with	IN
cord-015910-d9gxew91	300	27	a	a	DT
cord-015910-d9gxew91	300	28	history	history	NN
cord-015910-d9gxew91	300	29	of	of	IN
cord-015910-d9gxew91	300	30	ischemic	ischemic	JJ
cord-015910-d9gxew91	300	31	stroke	stroke	NN
cord-015910-d9gxew91	300	32	under	under	IN
cord-015910-d9gxew91	300	33	the	the	DT
cord-015910-d9gxew91	300	34	age	age	NN
cord-015910-d9gxew91	300	35	of	of	IN
cord-015910-d9gxew91	300	36	50	50	CD
cord-015910-d9gxew91	300	37	and	and	CC
cord-015910-d9gxew91	300	38	age	age	NN
cord-015910-d9gxew91	300	39	-	-	HYPH
cord-015910-d9gxew91	300	40	and	and	CC
cord-015910-d9gxew91	300	41	sex	sex	NN
cord-015910-d9gxew91	300	42	-	-	HYPH
cord-015910-d9gxew91	300	43	matched	match	VBN
cord-015910-d9gxew91	300	44	healthy	healthy	JJ
cord-015910-d9gxew91	300	45	control	control	NN
cord-015910-d9gxew91	300	46	subjects	subject	NNS
cord-015910-d9gxew91	300	47	.	.	.
cord-015910-d9gxew91	301	1	Release	release	NN
cord-015910-d9gxew91	301	2	oflL-8	oflL-8	NNP
cord-015910-d9gxew91	301	3	was	be	VBD
cord-015910-d9gxew91	301	4	significantly	significantly	RB
cord-015910-d9gxew91	301	5	higher	high	JJR
cord-015910-d9gxew91	301	6	in	in	IN
cord-015910-d9gxew91	301	7	young	young	JJ
cord-015910-d9gxew91	301	8	stroke	stroke	NN
cord-015910-d9gxew91	301	9	patients	patient	NNS
cord-015910-d9gxew91	301	10	than	than	IN
cord-015910-d9gxew91	301	11	in	in	IN
cord-015910-d9gxew91	301	12	control	control	NN
cord-015910-d9gxew91	301	13	subjects	subject	NNS
cord-015910-d9gxew91	301	14	(	(	-LRB-
cord-015910-d9gxew91	301	15	Grau	Grau	NNP
cord-015910-d9gxew91	301	16	et	et	NNP
cord-015910-d9gxew91	301	17	al	al	NNP
cord-015910-d9gxew91	301	18	.	.	NNP
cord-015910-d9gxew91	301	19	,	,	,
cord-015910-d9gxew91	301	20	2001	2001	CD
cord-015910-d9gxew91	301	21	)	)	-RRB-
cord-015910-d9gxew91	301	22	.	.	.
cord-015910-d9gxew91	302	1	The	the	DT
cord-015910-d9gxew91	302	2	question	question	NN
cord-015910-d9gxew91	302	3	of	of	IN
cord-015910-d9gxew91	302	4	whether	whether	IN
cord-015910-d9gxew91	302	5	aging	aging	NN
cord-015910-d9gxew91	302	6	is	be	VBZ
cord-015910-d9gxew91	302	7	associated	associate	VBN
cord-015910-d9gxew91	302	8	with	with	IN
cord-015910-d9gxew91	302	9	chronic	chronic	JJ
cord-015910-d9gxew91	302	10	elevation	elevation	NN
cord-015910-d9gxew91	302	11	of	of	IN
cord-015910-d9gxew91	302	12	cytokine	cytokine	NN
cord-015910-d9gxew91	302	13	production	production	NN
cord-015910-d9gxew91	302	14	or	or	CC
cord-015910-d9gxew91	302	15	whether	whether	IN
cord-015910-d9gxew91	302	16	an	an	DT
cord-015910-d9gxew91	302	17	increased	increase	VBN
cord-015910-d9gxew91	302	18	capacity	capacity	NN
cord-015910-d9gxew91	302	19	for	for	IN
cord-015910-d9gxew91	302	20	cytokine	cytokine	NN
cord-015910-d9gxew91	302	21	production	production	NN
cord-015910-d9gxew91	302	22	following	follow	VBG
cord-015910-d9gxew91	302	23	the	the	DT
cord-015910-d9gxew91	302	24	normal	normal	JJ
cord-015910-d9gxew91	302	25	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	302	26	challenges	challenge	NNS
cord-015910-d9gxew91	302	27	of	of	IN
cord-015910-d9gxew91	302	28	life	life	NN
cord-015910-d9gxew91	302	29	develops	develop	VBZ
cord-015910-d9gxew91	302	30	during	during	IN
cord-015910-d9gxew91	302	31	aging	age	VBG
cord-015910-d9gxew91	302	32	is	be	VBZ
cord-015910-d9gxew91	302	33	an	an	DT
cord-015910-d9gxew91	302	34	interesting	interesting	JJ
cord-015910-d9gxew91	302	35	one	one	NN
cord-015910-d9gxew91	302	36	to	to	TO
cord-015910-d9gxew91	302	37	consider	consider	VB
cord-015910-d9gxew91	302	38	.	.	.
cord-015910-d9gxew91	303	1	Insight	insight	NN
cord-015910-d9gxew91	303	2	into	into	IN
cord-015910-d9gxew91	303	3	this	this	DT
cord-015910-d9gxew91	303	4	issue	issue	NN
cord-015910-d9gxew91	303	5	can	can	MD
cord-015910-d9gxew91	303	6	be	be	VB
cord-015910-d9gxew91	303	7	gained	gain	VBN
cord-015910-d9gxew91	303	8	from	from	IN
cord-015910-d9gxew91	303	9	the	the	DT
cord-015910-d9gxew91	303	10	response	response	NN
cord-015910-d9gxew91	303	11	to	to	IN
cord-015910-d9gxew91	303	12	surgery	surgery	NN
cord-015910-d9gxew91	303	13	where	where	WRB
cord-015910-d9gxew91	303	14	an	an	DT
cord-015910-d9gxew91	303	15	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	303	16	stimulus	stimulus	NN
cord-015910-d9gxew91	303	17	is	be	VBZ
cord-015910-d9gxew91	303	18	applied	apply	VBN
cord-015910-d9gxew91	303	19	at	at	IN
cord-015910-d9gxew91	303	20	a	a	DT
cord-015910-d9gxew91	303	21	defined	define	VBN
cord-015910-d9gxew91	303	22	moment	moment	NN
cord-015910-d9gxew91	303	23	in	in	IN
cord-015910-d9gxew91	303	24	time	time	NN
cord-015910-d9gxew91	303	25	,	,	,
cord-015910-d9gxew91	303	26	making	make	VBG
cord-015910-d9gxew91	303	27	it	-PRON-	PRP
cord-015910-d9gxew91	303	28	easy	easy	JJ
cord-015910-d9gxew91	303	29	to	to	TO
cord-015910-d9gxew91	303	30	follow	follow	VB
cord-015910-d9gxew91	303	31	the	the	DT
cord-015910-d9gxew91	303	32	subsequent	subsequent	JJ
cord-015910-d9gxew91	303	33	response	response	NN
cord-015910-d9gxew91	303	34	.	.	.
cord-015910-d9gxew91	304	1	Ono	Ono	NNP
cord-015910-d9gxew91	304	2	,	,	,
cord-015910-d9gxew91	304	3	Aosasa	Aosasa	NNP
cord-015910-d9gxew91	304	4	,	,	,
cord-015910-d9gxew91	304	5	Tsujimoto	Tsujimoto	NNP
cord-015910-d9gxew91	304	6	,	,	,
cord-015910-d9gxew91	304	7	Ueno	Ueno	NNP
cord-015910-d9gxew91	304	8	,	,	,
cord-015910-d9gxew91	304	9	and	and	CC
cord-015910-d9gxew91	304	10	Mochizuki	Mochizuki	NNP
cord-015910-d9gxew91	304	11	(	(	-LRB-
cord-015910-d9gxew91	304	12	2001	2001	CD
cord-015910-d9gxew91	304	13	)	)	-RRB-
cord-015910-d9gxew91	304	14	investigated	investigate	VBD
cord-015910-d9gxew91	304	15	the	the	DT
cord-015910-d9gxew91	304	16	agerelated	agerelate	VBN
cord-015910-d9gxew91	304	17	changes	change	NNS
cord-015910-d9gxew91	304	18	in	in	IN
cord-015910-d9gxew91	304	19	the	the	DT
cord-015910-d9gxew91	304	20	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	304	21	response	response	NN
cord-015910-d9gxew91	304	22	in	in	IN
cord-015910-d9gxew91	304	23	patients	patient	NNS
cord-015910-d9gxew91	304	24	with	with	IN
cord-015910-d9gxew91	304	25	gastric	gastric	JJ
cord-015910-d9gxew91	304	26	cancer	cancer	NN
cord-015910-d9gxew91	304	27	undergoing	undergo	VBG
cord-015910-d9gxew91	304	28	distal	distal	JJ
cord-015910-d9gxew91	304	29	gastrectomy	gastrectomy	NN
cord-015910-d9gxew91	304	30	.	.	.
cord-015910-d9gxew91	305	1	Patients	patient	NNS
cord-015910-d9gxew91	305	2	were	be	VBD
cord-015910-d9gxew91	305	3	divided	divide	VBN
cord-015910-d9gxew91	305	4	into	into	IN
cord-015910-d9gxew91	305	5	two	two	CD
cord-015910-d9gxew91	305	6	groups	group	NNS
cord-015910-d9gxew91	305	7	:	:	:
cord-015910-d9gxew91	306	1	>	>	XX
cord-015910-d9gxew91	307	1	75	75	CD
cord-015910-d9gxew91	307	2	yr	yr	NN
cord-015910-d9gxew91	307	3	of	of	IN
cord-015910-d9gxew91	307	4	age	age	NN
cord-015910-d9gxew91	307	5	(	(	-LRB-
cord-015910-d9gxew91	307	6	elderly	elderly	JJ
cord-015910-d9gxew91	307	7	group	group	NN
cord-015910-d9gxew91	307	8	)	)	-RRB-
cord-015910-d9gxew91	307	9	and	and	CC
cord-015910-d9gxew91	308	1	-<75	-<75	NNP
cord-015910-d9gxew91	308	2	years	year	NNS
cord-015910-d9gxew91	308	3	of	of	IN
cord-015910-d9gxew91	308	4	age	age	NN
cord-015910-d9gxew91	308	5	(	(	-LRB-
cord-015910-d9gxew91	308	6	young	young	JJ
cord-015910-d9gxew91	308	7	group	group	NN
cord-015910-d9gxew91	308	8	)	)	-RRB-
cord-015910-d9gxew91	308	9	.	.	.
cord-015910-d9gxew91	309	1	Serum	serum	NN
cord-015910-d9gxew91	309	2	IL-6	IL-6	NNP
cord-015910-d9gxew91	309	3	concentrations	concentration	NNS
cord-015910-d9gxew91	309	4	,	,	,
cord-015910-d9gxew91	309	5	TNF	TNF	NNP
cord-015910-d9gxew91	309	6	-	-	HYPH
cord-015910-d9gxew91	309	7	ct	ct	NNP
cord-015910-d9gxew91	309	8	production	production	NN
cord-015910-d9gxew91	309	9	and	and	CC
cord-015910-d9gxew91	309	10	CD	CD	NNP
cord-015910-d9gxew91	309	11	11	11	CD
cord-015910-d9gxew91	309	12	b	b	NN
cord-015910-d9gxew91	309	13	/	/	SYM
cord-015910-d9gxew91	309	14	CD	cd	NN
cord-015910-d9gxew91	309	15	18	18	CD
cord-015910-d9gxew91	309	16	expression	expression	NN
cord-015910-d9gxew91	309	17	by	by	IN
cord-015910-d9gxew91	309	18	monocytes	monocyte	NNS
cord-015910-d9gxew91	309	19	,	,	,
cord-015910-d9gxew91	309	20	and	and	CC
cord-015910-d9gxew91	309	21	the	the	DT
cord-015910-d9gxew91	309	22	postoperative	postoperative	JJ
cord-015910-d9gxew91	309	23	clinical	clinical	JJ
cord-015910-d9gxew91	309	24	course	course	NN
cord-015910-d9gxew91	309	25	were	be	VBD
cord-015910-d9gxew91	309	26	compared	compare	VBN
cord-015910-d9gxew91	309	27	between	between	IN
cord-015910-d9gxew91	309	28	the	the	DT
cord-015910-d9gxew91	309	29	two	two	CD
cord-015910-d9gxew91	309	30	groups	group	NNS
cord-015910-d9gxew91	309	31	to	to	TO
cord-015910-d9gxew91	309	32	assess	assess	VB
cord-015910-d9gxew91	309	33	the	the	DT
cord-015910-d9gxew91	309	34	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	309	35	response	response	NN
cord-015910-d9gxew91	309	36	to	to	IN
cord-015910-d9gxew91	309	37	surgery	surgery	NN
cord-015910-d9gxew91	309	38	.	.	.
cord-015910-d9gxew91	310	1	TNF-~	tnf-~	CD
cord-015910-d9gxew91	310	2	production	production	NN
cord-015910-d9gxew91	310	3	by	by	IN
cord-015910-d9gxew91	310	4	LPS	LPS	NNP
cord-015910-d9gxew91	310	5	-	-	HYPH
cord-015910-d9gxew91	310	6	stimulated	stimulate	VBN
cord-015910-d9gxew91	310	7	monocytes	monocyte	NNS
cord-015910-d9gxew91	310	8	and	and	CC
cord-015910-d9gxew91	310	9	CD	cd	NN
cord-015910-d9gxew91	310	10	1	1	CD
cord-015910-d9gxew91	310	11	l	l	NN
cord-015910-d9gxew91	310	12	b	b	NNP
cord-015910-d9gxew91	310	13	/	/	SYM
cord-015910-d9gxew91	310	14	CD	CD	NNP
cord-015910-d9gxew91	310	15	18	18	CD
cord-015910-d9gxew91	310	16	expression	expression	NN
cord-015910-d9gxew91	310	17	on	on	IN
cord-015910-d9gxew91	310	18	monocytes	monocyte	NNS
cord-015910-d9gxew91	310	19	were	be	VBD
cord-015910-d9gxew91	310	20	significantly	significantly	RB
cord-015910-d9gxew91	310	21	higher	high	JJR
cord-015910-d9gxew91	310	22	in	in	IN
cord-015910-d9gxew91	310	23	the	the	DT
cord-015910-d9gxew91	310	24	elderly	elderly	JJ
cord-015910-d9gxew91	310	25	than	than	IN
cord-015910-d9gxew91	310	26	in	in	IN
cord-015910-d9gxew91	310	27	the	the	DT
cord-015910-d9gxew91	310	28	young	young	JJ
cord-015910-d9gxew91	310	29	group	group	NN
cord-015910-d9gxew91	310	30	.	.	.
cord-015910-d9gxew91	311	1	Moreover	moreover	RB
cord-015910-d9gxew91	311	2	,	,	,
cord-015910-d9gxew91	311	3	serum	serum	NN
cord-015910-d9gxew91	311	4	IL-6	IL-6	NNP
cord-015910-d9gxew91	311	5	concentrations	concentration	NNS
cord-015910-d9gxew91	311	6	on	on	IN
cord-015910-d9gxew91	311	7	the	the	DT
cord-015910-d9gxew91	311	8	first	first	JJ
cord-015910-d9gxew91	311	9	postoperative	postoperative	JJ
cord-015910-d9gxew91	311	10	day	day	NN
cord-015910-d9gxew91	311	11	in	in	IN
cord-015910-d9gxew91	311	12	the	the	DT
cord-015910-d9gxew91	311	13	elderly	elderly	JJ
cord-015910-d9gxew91	311	14	group	group	NN
cord-015910-d9gxew91	311	15	were	be	VBD
cord-015910-d9gxew91	311	16	significantly	significantly	RB
cord-015910-d9gxew91	311	17	higher	high	JJR
cord-015910-d9gxew91	311	18	than	than	IN
cord-015910-d9gxew91	311	19	those	those	DT
cord-015910-d9gxew91	311	20	in	in	IN
cord-015910-d9gxew91	311	21	the	the	DT
cord-015910-d9gxew91	311	22	young	young	JJ
cord-015910-d9gxew91	311	23	group	group	NN
cord-015910-d9gxew91	311	24	.	.	.
cord-015910-d9gxew91	312	1	Paradoxically	paradoxically	RB
cord-015910-d9gxew91	312	2	,	,	,
cord-015910-d9gxew91	312	3	both	both	DT
cord-015910-d9gxew91	312	4	loss	loss	NN
cord-015910-d9gxew91	312	5	of	of	IN
cord-015910-d9gxew91	312	6	body	body	NN
cord-015910-d9gxew91	312	7	weight	weight	NN
cord-015910-d9gxew91	312	8	and	and	CC
cord-015910-d9gxew91	312	9	lean	lean	JJ
cord-015910-d9gxew91	312	10	tissue	tissue	NN
cord-015910-d9gxew91	312	11	and	and	CC
cord-015910-d9gxew91	312	12	obesity	obesity	NN
cord-015910-d9gxew91	312	13	are	be	VBP
cord-015910-d9gxew91	312	14	found	find	VBN
cord-015910-d9gxew91	312	15	in	in	IN
cord-015910-d9gxew91	312	16	elderly	elderly	JJ
cord-015910-d9gxew91	312	17	populations	population	NNS
cord-015910-d9gxew91	312	18	.	.	.
cord-015910-d9gxew91	313	1	Is	be	VBZ
cord-015910-d9gxew91	313	2	there	there	EX
cord-015910-d9gxew91	313	3	,	,	,
cord-015910-d9gxew91	313	4	therefore	therefore	RB
cord-015910-d9gxew91	313	5	,	,	,
cord-015910-d9gxew91	313	6	a	a	DT
cord-015910-d9gxew91	313	7	link	link	NN
cord-015910-d9gxew91	313	8	between	between	IN
cord-015910-d9gxew91	313	9	this	this	DT
cord-015910-d9gxew91	313	10	phenomenon	phenomenon	NN
cord-015910-d9gxew91	313	11	and	and	CC
cord-015910-d9gxew91	313	12	increased	increase	VBN
cord-015910-d9gxew91	313	13	levels	level	NNS
cord-015910-d9gxew91	313	14	of	of	IN
cord-015910-d9gxew91	313	15	inflammation	inflammation	NN
cord-015910-d9gxew91	313	16	?	?	.
cord-015910-d9gxew91	314	1	The	the	DT
cord-015910-d9gxew91	314	2	loss	loss	NN
cord-015910-d9gxew91	314	3	of	of	IN
cord-015910-d9gxew91	314	4	muscle	muscle	NN
cord-015910-d9gxew91	314	5	mass	mass	NN
cord-015910-d9gxew91	314	6	and	and	CC
cord-015910-d9gxew91	314	7	strength	strength	NN
cord-015910-d9gxew91	314	8	that	that	WDT
cord-015910-d9gxew91	314	9	occurs	occur	VBZ
cord-015910-d9gxew91	314	10	with	with	IN
cord-015910-d9gxew91	314	11	aging	aging	NN
cord-015910-d9gxew91	314	12	is	be	VBZ
cord-015910-d9gxew91	314	13	described	describe	VBN
cord-015910-d9gxew91	314	14	clinically	clinically	RB
cord-015910-d9gxew91	314	15	as	as	IN
cord-015910-d9gxew91	314	16	sarcopenia	sarcopenia	NN
cord-015910-d9gxew91	314	17	(	(	-LRB-
cord-015910-d9gxew91	314	18	Rosenberg	Rosenberg	NNP
cord-015910-d9gxew91	314	19	,	,	,
cord-015910-d9gxew91	314	20	1989	1989	CD
cord-015910-d9gxew91	314	21	;	;	:
cord-015910-d9gxew91	314	22	Roubenoff	Roubenoff	NNP
cord-015910-d9gxew91	314	23	,	,	,
cord-015910-d9gxew91	314	24	2001	2001	CD
cord-015910-d9gxew91	314	25	)	)	-RRB-
cord-015910-d9gxew91	314	26	.	.	.
cord-015910-d9gxew91	315	1	It	-PRON-	PRP
cord-015910-d9gxew91	315	2	is	be	VBZ
cord-015910-d9gxew91	315	3	an	an	DT
cord-015910-d9gxew91	315	4	important	important	JJ
cord-015910-d9gxew91	315	5	contributor	contributor	NN
cord-015910-d9gxew91	315	6	to	to	IN
cord-015910-d9gxew91	315	7	the	the	DT
cord-015910-d9gxew91	315	8	development	development	NN
cord-015910-d9gxew91	315	9	of	of	IN
cord-015910-d9gxew91	315	10	frailty	frailty	NN
cord-015910-d9gxew91	315	11	and	and	CC
cord-015910-d9gxew91	315	12	functional	functional	JJ
cord-015910-d9gxew91	315	13	impairment	impairment	NN
cord-015910-d9gxew91	315	14	during	during	IN
cord-015910-d9gxew91	315	15	aging	age	VBG
cord-015910-d9gxew91	315	16	.	.	.
cord-015910-d9gxew91	316	1	It	-PRON-	PRP
cord-015910-d9gxew91	316	2	is	be	VBZ
cord-015910-d9gxew91	316	3	well	well	RB
cord-015910-d9gxew91	316	4	established	establish	VBN
cord-015910-d9gxew91	316	5	that	that	IN
cord-015910-d9gxew91	316	6	aging	aging	NN
cord-015910-d9gxew91	316	7	is	be	VBZ
cord-015910-d9gxew91	316	8	associated	associate	VBN
cord-015910-d9gxew91	316	9	with	with	IN
cord-015910-d9gxew91	316	10	a	a	DT
cord-015910-d9gxew91	316	11	significant	significant	JJ
cord-015910-d9gxew91	316	12	decline	decline	NN
cord-015910-d9gxew91	316	13	in	in	IN
cord-015910-d9gxew91	316	14	muscle	muscle	NN
cord-015910-d9gxew91	316	15	strength	strength	NN
cord-015910-d9gxew91	316	16	that	that	WDT
cord-015910-d9gxew91	316	17	becomes	become	VBZ
cord-015910-d9gxew91	316	18	functionally	functionally	RB
cord-015910-d9gxew91	316	19	important	important	JJ
cord-015910-d9gxew91	316	20	by	by	IN
cord-015910-d9gxew91	316	21	the	the	DT
cord-015910-d9gxew91	316	22	seventh	seventh	JJ
cord-015910-d9gxew91	316	23	decade	decade	NN
cord-015910-d9gxew91	316	24	of	of	IN
cord-015910-d9gxew91	316	25	life	life	NN
cord-015910-d9gxew91	316	26	.	.	.
cord-015910-d9gxew91	317	1	The	the	DT
cord-015910-d9gxew91	317	2	relationship	relationship	NN
cord-015910-d9gxew91	317	3	between	between	IN
cord-015910-d9gxew91	317	4	chronic	chronic	JJ
cord-015910-d9gxew91	317	5	inflammation	inflammation	NN
cord-015910-d9gxew91	317	6	owing	owe	VBG
cord-015910-d9gxew91	317	7	to	to	IN
cord-015910-d9gxew91	317	8	disease	disease	NN
cord-015910-d9gxew91	317	9	during	during	IN
cord-015910-d9gxew91	317	10	aging	age	VBG
cord-015910-d9gxew91	317	11	and	and	CC
cord-015910-d9gxew91	317	12	the	the	DT
cord-015910-d9gxew91	317	13	prevalence	prevalence	NN
cord-015910-d9gxew91	317	14	of	of	IN
cord-015910-d9gxew91	317	15	low	low	JJ
cord-015910-d9gxew91	317	16	body	body	NN
cord-015910-d9gxew91	317	17	mass	mass	NN
cord-015910-d9gxew91	317	18	are	be	VBP
cord-015910-d9gxew91	317	19	well	well	RB
cord-015910-d9gxew91	317	20	illustrated	illustrate	VBN
cord-015910-d9gxew91	317	21	in	in	IN
cord-015910-d9gxew91	317	22	rheumatoid	rheumatoid	JJ
cord-015910-d9gxew91	317	23	arthritis	arthritis	NN
cord-015910-d9gxew91	317	24	.	.	.
cord-015910-d9gxew91	318	1	In	in	IN
cord-015910-d9gxew91	318	2	a	a	DT
cord-015910-d9gxew91	318	3	study	study	NN
cord-015910-d9gxew91	318	4	on	on	IN
cord-015910-d9gxew91	318	5	patients	patient	NNS
cord-015910-d9gxew91	318	6	with	with	IN
cord-015910-d9gxew91	318	7	rheumatoid	rheumatoid	NN
cord-015910-d9gxew91	318	8	arthritis	arthritis	NN
cord-015910-d9gxew91	318	9	,	,	,
cord-015910-d9gxew91	318	10	the	the	DT
cord-015910-d9gxew91	318	11	loss	loss	NN
cord-015910-d9gxew91	318	12	of	of	IN
cord-015910-d9gxew91	318	13	body	body	NN
cord-015910-d9gxew91	318	14	mass	mass	NN
cord-015910-d9gxew91	318	15	was	be	VBD
cord-015910-d9gxew91	318	16	greater	great	JJR
cord-015910-d9gxew91	318	17	for	for	IN
cord-015910-d9gxew91	318	18	lean	lean	JJ
cord-015910-d9gxew91	318	19	tissue	tissue	NN
cord-015910-d9gxew91	318	20	than	than	IN
cord-015910-d9gxew91	318	21	fat	fat	JJ
cord-015910-d9gxew91	318	22	,	,	,
cord-015910-d9gxew91	318	23	with	with	IN
cord-015910-d9gxew91	318	24	over	over	IN
cord-015910-d9gxew91	318	25	50	50	CD
cord-015910-d9gxew91	318	26	%	%	NN
cord-015910-d9gxew91	318	27	of	of	IN
cord-015910-d9gxew91	318	28	the	the	DT
cord-015910-d9gxew91	318	29	rheumatoid	rheumatoid	NN
cord-015910-d9gxew91	318	30	group	group	NN
cord-015910-d9gxew91	318	31	falling	fall	VBG
cord-015910-d9gxew91	318	32	into	into	IN
cord-015910-d9gxew91	318	33	the	the	DT
cord-015910-d9gxew91	318	34	lowest	low	JJS
cord-015910-d9gxew91	318	35	10th	10th	JJ
cord-015910-d9gxew91	318	36	percentile	percentile	NN
cord-015910-d9gxew91	318	37	of	of	IN
cord-015910-d9gxew91	318	38	a	a	DT
cord-015910-d9gxew91	318	39	reference	reference	NN
cord-015910-d9gxew91	318	40	population	population	NN
cord-015910-d9gxew91	318	41	for	for	IN
cord-015910-d9gxew91	318	42	skeletal	skeletal	JJ
cord-015910-d9gxew91	318	43	muscle	muscle	NN
cord-015910-d9gxew91	318	44	mass	mass	NN
cord-015910-d9gxew91	318	45	assessed	assess	VBN
cord-015910-d9gxew91	318	46	from	from	IN
cord-015910-d9gxew91	318	47	the	the	DT
cord-015910-d9gxew91	318	48	upper	upper	JJ
cord-015910-d9gxew91	318	49	arm	arm	NN
cord-015910-d9gxew91	318	50	muscle	muscle	NN
cord-015910-d9gxew91	318	51	area	area	NN
cord-015910-d9gxew91	318	52	.	.	.
cord-015910-d9gxew91	319	1	In	in	IN
cord-015910-d9gxew91	319	2	female	female	JJ
cord-015910-d9gxew91	319	3	patients	patient	NNS
cord-015910-d9gxew91	319	4	there	there	EX
cord-015910-d9gxew91	319	5	was	be	VBD
cord-015910-d9gxew91	319	6	a	a	DT
cord-015910-d9gxew91	319	7	significant	significant	JJ
cord-015910-d9gxew91	319	8	correlation	correlation	NN
cord-015910-d9gxew91	319	9	between	between	IN
cord-015910-d9gxew91	319	10	reduced	reduced	JJ
cord-015910-d9gxew91	319	11	fat	fat	NN
cord-015910-d9gxew91	319	12	-	-	HYPH
cord-015910-d9gxew91	319	13	free	free	JJ
cord-015910-d9gxew91	319	14	mass	mass	NN
cord-015910-d9gxew91	319	15	and	and	CC
cord-015910-d9gxew91	319	16	two	two	CD
cord-015910-d9gxew91	319	17	indicators	indicator	NNS
cord-015910-d9gxew91	319	18	of	of	IN
cord-015910-d9gxew91	319	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	319	20	stress	stress	NN
cord-015910-d9gxew91	319	21	---	---	:
cord-015910-d9gxew91	319	22	erythrocyte	erythrocyte	NN
cord-015910-d9gxew91	319	23	sedimentation	sedimentation	NN
cord-015910-d9gxew91	319	24	rate	rate	NN
cord-015910-d9gxew91	319	25	and	and	CC
cord-015910-d9gxew91	319	26	plasma	plasma	NN
cord-015910-d9gxew91	319	27	CRP	crp	NN
cord-015910-d9gxew91	319	28	concentration	concentration	NN
cord-015910-d9gxew91	319	29	(	(	-LRB-
cord-015910-d9gxew91	319	30	Munro	Munro	NNP
cord-015910-d9gxew91	319	31	&	&	CC
cord-015910-d9gxew91	319	32	Capell	Capell	NNP
cord-015910-d9gxew91	319	33	,	,	,
cord-015910-d9gxew91	319	34	1997	1997	CD
cord-015910-d9gxew91	319	35	)	)	-RRB-
cord-015910-d9gxew91	319	36	.	.	.
cord-015910-d9gxew91	320	1	Clinical	clinical	JJ
cord-015910-d9gxew91	320	2	and	and	CC
cord-015910-d9gxew91	320	3	animal	animal	NN
cord-015910-d9gxew91	320	4	studies	study	NNS
cord-015910-d9gxew91	320	5	show	show	VBP
cord-015910-d9gxew91	320	6	a	a	DT
cord-015910-d9gxew91	320	7	relationship	relationship	NN
cord-015910-d9gxew91	320	8	between	between	IN
cord-015910-d9gxew91	320	9	raised	raise	VBN
cord-015910-d9gxew91	320	10	plasma	plasma	NN
cord-015910-d9gxew91	320	11	cytokine	cytokine	NN
cord-015910-d9gxew91	320	12	concentrations	concentration	NNS
cord-015910-d9gxew91	320	13	and	and	CC
cord-015910-d9gxew91	320	14	low	low	JJ
cord-015910-d9gxew91	320	15	muscle	muscle	NN
cord-015910-d9gxew91	320	16	mass	mass	NN
cord-015910-d9gxew91	320	17	.	.	.
cord-015910-d9gxew91	321	1	Visser	Visser	NNP
cord-015910-d9gxew91	321	2	et	et	NNP
cord-015910-d9gxew91	321	3	al	al	NNP
cord-015910-d9gxew91	321	4	.	.	.
cord-015910-d9gxew91	322	1	(	(	-LRB-
cord-015910-d9gxew91	322	2	2002	2002	CD
cord-015910-d9gxew91	322	3	)	)	-RRB-
cord-015910-d9gxew91	322	4	investigated	investigate	VBD
cord-015910-d9gxew91	322	5	whether	whether	IN
cord-015910-d9gxew91	322	6	markers	marker	NNS
cord-015910-d9gxew91	322	7	of	of	IN
cord-015910-d9gxew91	322	8	inflammation	inflammation	NN
cord-015910-d9gxew91	322	9	are	be	VBP
cord-015910-d9gxew91	322	10	associated	associate	VBN
cord-015910-d9gxew91	322	11	with	with	IN
cord-015910-d9gxew91	322	12	muscle	muscle	NN
cord-015910-d9gxew91	322	13	mass	mass	NN
cord-015910-d9gxew91	322	14	and	and	CC
cord-015910-d9gxew91	322	15	strength	strength	NN
cord-015910-d9gxew91	322	16	over	over	IN
cord-015910-d9gxew91	322	17	a	a	DT
cord-015910-d9gxew91	322	18	time	time	NN
cord-015910-d9gxew91	322	19	course	course	NN
cord-015910-d9gxew91	322	20	of	of	IN
cord-015910-d9gxew91	322	21	several	several	JJ
cord-015910-d9gxew91	322	22	years	year	NNS
cord-015910-d9gxew91	322	23	in	in	IN
cord-015910-d9gxew91	322	24	over	over	IN
cord-015910-d9gxew91	322	25	3000	3000	CD
cord-015910-d9gxew91	322	26	healthy	healthy	JJ
cord-015910-d9gxew91	322	27	well	well	RB
cord-015910-d9gxew91	322	28	-	-	HYPH
cord-015910-d9gxew91	322	29	functioning	function	VBG
cord-015910-d9gxew91	322	30	black	black	JJ
cord-015910-d9gxew91	322	31	and	and	CC
cord-015910-d9gxew91	322	32	white	white	JJ
cord-015910-d9gxew91	322	33	elderly	elderly	JJ
cord-015910-d9gxew91	322	34	persons	person	NNS
cord-015910-d9gxew91	322	35	(	(	-LRB-
cord-015910-d9gxew91	322	36	70	70	CD
cord-015910-d9gxew91	322	37	-	-	SYM
cord-015910-d9gxew91	322	38	79	79	CD
cord-015910-d9gxew91	322	39	yr	yr	NN
cord-015910-d9gxew91	322	40	)	)	-RRB-
cord-015910-d9gxew91	322	41	.	.	.
cord-015910-d9gxew91	323	1	Mid	mid	JJ
cord-015910-d9gxew91	323	2	-	-	JJ
cord-015910-d9gxew91	323	3	thigh	thigh	NN
cord-015910-d9gxew91	323	4	muscle	muscle	NN
cord-015910-d9gxew91	323	5	cross	cross	JJ
cord-015910-d9gxew91	323	6	-	-	JJ
cord-015910-d9gxew91	323	7	sectional	sectional	JJ
cord-015910-d9gxew91	323	8	area	area	NN
cord-015910-d9gxew91	323	9	,	,	,
cord-015910-d9gxew91	323	10	appendicular	appendicular	NNP
cord-015910-d9gxew91	323	11	muscle	muscle	NNP
cord-015910-d9gxew91	323	12	mass	mass	NN
cord-015910-d9gxew91	323	13	,	,	,
cord-015910-d9gxew91	323	14	and	and	CC
cord-015910-d9gxew91	323	15	muscle	muscle	NN
cord-015910-d9gxew91	323	16	strength	strength	NN
cord-015910-d9gxew91	323	17	were	be	VBD
cord-015910-d9gxew91	323	18	assessed	assess	VBN
cord-015910-d9gxew91	323	19	.	.	.
cord-015910-d9gxew91	324	1	Plasma	plasma	NN
cord-015910-d9gxew91	324	2	concentrations	concentration	NNS
cord-015910-d9gxew91	324	3	of	of	IN
cord-015910-d9gxew91	324	4	IL-6	IL-6	NNP
cord-015910-d9gxew91	324	5	and	and	CC
cord-015910-d9gxew91	324	6	TNF-~	TNF-~	NNP
cord-015910-d9gxew91	324	7	were	be	VBD
cord-015910-d9gxew91	324	8	also	also	RB
cord-015910-d9gxew91	324	9	measured	measure	VBN
cord-015910-d9gxew91	324	10	.	.	.
cord-015910-d9gxew91	325	1	Higher	high	JJR
cord-015910-d9gxew91	325	2	cytokine	cytokine	NN
cord-015910-d9gxew91	325	3	concentrations	concentration	NNS
cord-015910-d9gxew91	325	4	were	be	VBD
cord-015910-d9gxew91	325	5	associated	associate	VBN
cord-015910-d9gxew91	325	6	with	with	IN
cord-015910-d9gxew91	325	7	lower	low	JJR
cord-015910-d9gxew91	325	8	muscle	muscle	NN
cord-015910-d9gxew91	325	9	mass	mass	NN
cord-015910-d9gxew91	325	10	and	and	CC
cord-015910-d9gxew91	325	11	lower	low	JJR
cord-015910-d9gxew91	325	12	muscle	muscle	NN
cord-015910-d9gxew91	325	13	strength	strength	NN
cord-015910-d9gxew91	325	14	.	.	.
cord-015910-d9gxew91	326	1	The	the	DT
cord-015910-d9gxew91	326	2	most	most	RBS
cord-015910-d9gxew91	326	3	consistent	consistent	JJ
cord-015910-d9gxew91	326	4	relationship	relationship	NN
cord-015910-d9gxew91	326	5	across	across	IN
cord-015910-d9gxew91	326	6	the	the	DT
cord-015910-d9gxew91	326	7	gender	gender	NN
cord-015910-d9gxew91	326	8	and	and	CC
cord-015910-d9gxew91	326	9	race	race	NN
cord-015910-d9gxew91	326	10	groups	group	NNS
cord-015910-d9gxew91	326	11	was	be	VBD
cord-015910-d9gxew91	326	12	observed	observe	VBN
cord-015910-d9gxew91	326	13	for	for	IN
cord-015910-d9gxew91	326	14	IL-6	IL-6	NNP
cord-015910-d9gxew91	326	15	and	and	CC
cord-015910-d9gxew91	326	16	grip	grip	NN
cord-015910-d9gxew91	326	17	strength	strength	NN
cord-015910-d9gxew91	326	18	.	.	.
cord-015910-d9gxew91	327	1	When	when	WRB
cord-015910-d9gxew91	327	2	an	an	DT
cord-015910-d9gxew91	327	3	overall	overall	JJ
cord-015910-d9gxew91	327	4	indicator	indicator	NN
cord-015910-d9gxew91	327	5	of	of	IN
cord-015910-d9gxew91	327	6	elevated	elevated	JJ
cord-015910-d9gxew91	327	7	cytokine	cytokine	NN
cord-015910-d9gxew91	327	8	production	production	NN
cord-015910-d9gxew91	327	9	was	be	VBD
cord-015910-d9gxew91	327	10	created	create	VBN
cord-015910-d9gxew91	327	11	by	by	IN
cord-015910-d9gxew91	327	12	combining	combine	VBG
cord-015910-d9gxew91	327	13	the	the	DT
cord-015910-d9gxew91	327	14	concentrations	concentration	NNS
cord-015910-d9gxew91	327	15	of	of	IN
cord-015910-d9gxew91	327	16	IL-6	IL-6	NNP
cord-015910-d9gxew91	327	17	and	and	CC
cord-015910-d9gxew91	327	18	TNF	TNF	NNP
cord-015910-d9gxew91	327	19	-	-	HYPH
cord-015910-d9gxew91	327	20	o~	o~	NNP
cord-015910-d9gxew91	327	21	,	,	,
cord-015910-d9gxew91	327	22	with	with	IN
cord-015910-d9gxew91	327	23	the	the	DT
cord-015910-d9gxew91	327	24	exception	exception	NN
cord-015910-d9gxew91	327	25	of	of	IN
cord-015910-d9gxew91	327	26	white	white	JJ
cord-015910-d9gxew91	327	27	men	man	NNS
cord-015910-d9gxew91	327	28	,	,	,
cord-015910-d9gxew91	327	29	elderly	elderly	JJ
cord-015910-d9gxew91	327	30	persons	person	NNS
cord-015910-d9gxew91	327	31	having	have	VBG
cord-015910-d9gxew91	327	32	high	high	JJ
cord-015910-d9gxew91	327	33	concentrations	concentration	NNS
cord-015910-d9gxew91	327	34	of	of	IN
cord-015910-d9gxew91	327	35	IL-6	IL-6	NNP
cord-015910-d9gxew91	327	36	(	(	-LRB-
cord-015910-d9gxew91	327	37	>	>	NFP
cord-015910-d9gxew91	327	38	1.80	1.80	CD
cord-015910-d9gxew91	327	39	pg	pg	NN
cord-015910-d9gxew91	327	40	/	/	SYM
cord-015910-d9gxew91	327	41	mL	mL	NNP
cord-015910-d9gxew91	327	42	)	)	-RRB-
cord-015910-d9gxew91	327	43	as	as	RB
cord-015910-d9gxew91	327	44	well	well	RB
cord-015910-d9gxew91	327	45	as	as	IN
cord-015910-d9gxew91	327	46	high	high	JJ
cord-015910-d9gxew91	327	47	levels	level	NNS
cord-015910-d9gxew91	327	48	of	of	IN
cord-015910-d9gxew91	327	49	TNF-~	TNF-~	NNP
cord-015910-d9gxew91	327	50	(	(	-LRB-
cord-015910-d9gxew91	327	51	>	>	NFP
cord-015910-d9gxew91	327	52	3.20	3.20	CD
cord-015910-d9gxew91	327	53	pg	pg	NN
cord-015910-d9gxew91	327	54	/	/	SYM
cord-015910-d9gxew91	327	55	mL	mL	NNP
cord-015910-d9gxew91	327	56	)	)	-RRB-
cord-015910-d9gxew91	327	57	had	have	VBD
cord-015910-d9gxew91	327	58	a	a	DT
cord-015910-d9gxew91	327	59	smaller	small	JJR
cord-015910-d9gxew91	327	60	muscle	muscle	NN
cord-015910-d9gxew91	327	61	area	area	NN
cord-015910-d9gxew91	327	62	,	,	,
cord-015910-d9gxew91	327	63	less	less	RBR
cord-015910-d9gxew91	327	64	appendicular	appendicular	JJ
cord-015910-d9gxew91	327	65	muscle	muscle	NN
cord-015910-d9gxew91	327	66	mass	mass	NN
cord-015910-d9gxew91	327	67	,	,	,
cord-015910-d9gxew91	327	68	and	and	CC
cord-015910-d9gxew91	327	69	lower	low	JJR
cord-015910-d9gxew91	327	70	muscle	muscle	NN
cord-015910-d9gxew91	327	71	strength	strength	NN
cord-015910-d9gxew91	327	72	compared	compare	VBN
cord-015910-d9gxew91	327	73	to	to	IN
cord-015910-d9gxew91	327	74	those	those	DT
cord-015910-d9gxew91	327	75	with	with	IN
cord-015910-d9gxew91	327	76	low	low	JJ
cord-015910-d9gxew91	327	77	levels	level	NNS
cord-015910-d9gxew91	327	78	of	of	IN
cord-015910-d9gxew91	327	79	both	both	DT
cord-015910-d9gxew91	327	80	cytokines	cytokine	NNS
cord-015910-d9gxew91	327	81	.	.	.
cord-015910-d9gxew91	328	1	Thus	thus	RB
cord-015910-d9gxew91	328	2	,	,	,
cord-015910-d9gxew91	328	3	raised	raise	VBD
cord-015910-d9gxew91	328	4	plasma	plasma	NN
cord-015910-d9gxew91	328	5	concentrations	concentration	NNS
cord-015910-d9gxew91	328	6	of	of	IN
cord-015910-d9gxew91	328	7	IL-6	IL-6	NNP
cord-015910-d9gxew91	328	8	and	and	CC
cord-015910-d9gxew91	328	9	TNF-~	TNF-~	NNP
cord-015910-d9gxew91	328	10	are	be	VBP
cord-015910-d9gxew91	328	11	associated	associate	VBN
cord-015910-d9gxew91	328	12	with	with	IN
cord-015910-d9gxew91	328	13	lower	low	JJR
cord-015910-d9gxew91	328	14	muscle	muscle	NN
cord-015910-d9gxew91	328	15	mass	mass	NN
cord-015910-d9gxew91	328	16	and	and	CC
cord-015910-d9gxew91	328	17	lower	low	JJR
cord-015910-d9gxew91	328	18	muscle	muscle	NN
cord-015910-d9gxew91	328	19	strength	strength	NN
cord-015910-d9gxew91	328	20	in	in	IN
cord-015910-d9gxew91	328	21	well	well	RB
cord-015910-d9gxew91	328	22	-	-	HYPH
cord-015910-d9gxew91	328	23	functioning	function	VBG
cord-015910-d9gxew91	328	24	older	old	JJR
cord-015910-d9gxew91	328	25	men	man	NNS
cord-015910-d9gxew91	328	26	and	and	CC
cord-015910-d9gxew91	328	27	women	woman	NNS
cord-015910-d9gxew91	328	28	as	as	RB
cord-015910-d9gxew91	328	29	well	well	RB
cord-015910-d9gxew91	328	30	as	as	IN
cord-015910-d9gxew91	328	31	those	those	DT
cord-015910-d9gxew91	328	32	suffering	suffer	VBG
cord-015910-d9gxew91	328	33	frank	frank	JJ
cord-015910-d9gxew91	328	34	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	328	35	disease	disease	NN
cord-015910-d9gxew91	328	36	.	.	.
cord-015910-d9gxew91	329	1	Nutrient	nutrient	NN
cord-015910-d9gxew91	329	2	intake	intake	NN
cord-015910-d9gxew91	329	3	is	be	VBZ
cord-015910-d9gxew91	329	4	clearly	clearly	RB
cord-015910-d9gxew91	329	5	another	another	DT
cord-015910-d9gxew91	329	6	important	important	JJ
cord-015910-d9gxew91	329	7	determinant	determinant	NN
cord-015910-d9gxew91	329	8	of	of	IN
cord-015910-d9gxew91	329	9	lean	lean	JJ
cord-015910-d9gxew91	329	10	body	body	NN
cord-015910-d9gxew91	329	11	weight	weight	NN
cord-015910-d9gxew91	329	12	and	and	CC
cord-015910-d9gxew91	329	13	fat	fat	JJ
cord-015910-d9gxew91	329	14	mass	mass	NN
cord-015910-d9gxew91	329	15	and	and	CC
cord-015910-d9gxew91	329	16	may	may	MD
cord-015910-d9gxew91	329	17	play	play	VB
cord-015910-d9gxew91	329	18	a	a	DT
cord-015910-d9gxew91	329	19	part	part	NN
cord-015910-d9gxew91	329	20	in	in	IN
cord-015910-d9gxew91	329	21	the	the	DT
cord-015910-d9gxew91	329	22	decline	decline	NN
cord-015910-d9gxew91	329	23	in	in	IN
cord-015910-d9gxew91	329	24	lean	lean	JJ
cord-015910-d9gxew91	329	25	tissue	tissue	NN
cord-015910-d9gxew91	329	26	with	with	IN
cord-015910-d9gxew91	329	27	age	age	NN
cord-015910-d9gxew91	329	28	as	as	RB
cord-015910-d9gxew91	329	29	well	well	RB
cord-015910-d9gxew91	329	30	as	as	IN
cord-015910-d9gxew91	329	31	an	an	DT
cord-015910-d9gxew91	329	32	increase	increase	NN
cord-015910-d9gxew91	329	33	in	in	IN
cord-015910-d9gxew91	329	34	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	329	35	stress	stress	NN
cord-015910-d9gxew91	329	36	.	.	.
cord-015910-d9gxew91	330	1	A	a	DT
cord-015910-d9gxew91	330	2	recent	recent	JJ
cord-015910-d9gxew91	330	3	survey	survey	NN
cord-015910-d9gxew91	330	4	of	of	IN
cord-015910-d9gxew91	330	5	40,000	40,000	CD
cord-015910-d9gxew91	330	6	subjects	subject	NNS
cord-015910-d9gxew91	330	7	in	in	IN
cord-015910-d9gxew91	330	8	88	88	CD
cord-015910-d9gxew91	330	9	communities	community	NNS
cord-015910-d9gxew91	330	10	in	in	IN
cord-015910-d9gxew91	330	11	NHANES	NHANES	NNP
cord-015910-d9gxew91	330	12	III	III	NNP
cord-015910-d9gxew91	330	13	in	in	IN
cord-015910-d9gxew91	330	14	the	the	DT
cord-015910-d9gxew91	330	15	United	United	NNP
cord-015910-d9gxew91	330	16	States	States	NNP
cord-015910-d9gxew91	330	17	also	also	RB
cord-015910-d9gxew91	330	18	included	include	VBD
cord-015910-d9gxew91	330	19	a	a	DT
cord-015910-d9gxew91	330	20	survey	survey	NN
cord-015910-d9gxew91	330	21	of	of	IN
cord-015910-d9gxew91	330	22	about	about	RB
cord-015910-d9gxew91	330	23	5000	5000	CD
cord-015910-d9gxew91	330	24	elderly	elderly	JJ
cord-015910-d9gxew91	330	25	people	people	NNS
cord-015910-d9gxew91	330	26	ranging	range	VBG
cord-015910-d9gxew91	330	27	in	in	IN
cord-015910-d9gxew91	330	28	age	age	NN
cord-015910-d9gxew91	330	29	from	from	IN
cord-015910-d9gxew91	330	30	60	60	CD
cord-015910-d9gxew91	330	31	to	to	TO
cord-015910-d9gxew91	330	32	69	69	CD
cord-015910-d9gxew91	330	33	yr	yr	NN
cord-015910-d9gxew91	330	34	,	,	,
cord-015910-d9gxew91	330	35	70	70	CD
cord-015910-d9gxew91	330	36	to	to	TO
cord-015910-d9gxew91	330	37	79	79	CD
cord-015910-d9gxew91	330	38	yr	yr	NN
cord-015910-d9gxew91	330	39	,	,	,
cord-015910-d9gxew91	330	40	and	and	CC
cord-015910-d9gxew91	330	41	80	80	CD
cord-015910-d9gxew91	330	42	+	+	SYM
cord-015910-d9gxew91	330	43	yr	yr	NN
cord-015910-d9gxew91	330	44	(	(	-LRB-
cord-015910-d9gxew91	330	45	Marwick	Marwick	NNP
cord-015910-d9gxew91	330	46	,	,	,
cord-015910-d9gxew91	330	47	1997	1997	CD
cord-015910-d9gxew91	330	48	)	)	-RRB-
cord-015910-d9gxew91	330	49	.	.	.
cord-015910-d9gxew91	331	1	The	the	DT
cord-015910-d9gxew91	331	2	report	report	NN
cord-015910-d9gxew91	331	3	indicated	indicate	VBD
cord-015910-d9gxew91	331	4	that	that	IN
cord-015910-d9gxew91	331	5	the	the	DT
cord-015910-d9gxew91	331	6	median	median	JJ
cord-015910-d9gxew91	331	7	intake	intake	NN
cord-015910-d9gxew91	331	8	of	of	IN
cord-015910-d9gxew91	331	9	total	total	JJ
cord-015910-d9gxew91	331	10	energy	energy	NN
cord-015910-d9gxew91	331	11	was	be	VBD
cord-015910-d9gxew91	331	12	in	in	IN
cord-015910-d9gxew91	331	13	general	general	JJ
cord-015910-d9gxew91	331	14	lower	low	JJR
cord-015910-d9gxew91	331	15	than	than	IN
cord-015910-d9gxew91	331	16	the	the	DT
cord-015910-d9gxew91	331	17	recommended	recommend	VBN
cord-015910-d9gxew91	331	18	2300	2300	CD
cord-015910-d9gxew91	331	19	kcal	kcal	NNS
cord-015910-d9gxew91	331	20	for	for	IN
cord-015910-d9gxew91	331	21	men	man	NNS
cord-015910-d9gxew91	331	22	and	and	CC
cord-015910-d9gxew91	331	23	1900	1900	CD
cord-015910-d9gxew91	331	24	kcal	kcal	NNS
cord-015910-d9gxew91	331	25	for	for	IN
cord-015910-d9gxew91	331	26	women	woman	NNS
cord-015910-d9gxew91	331	27	(	(	-LRB-
cord-015910-d9gxew91	331	28	Marwick	Marwick	NNP
cord-015910-d9gxew91	331	29	,	,	,
cord-015910-d9gxew91	331	30	1997	1997	CD
cord-015910-d9gxew91	331	31	)	)	-RRB-
cord-015910-d9gxew91	331	32	.	.	.
cord-015910-d9gxew91	332	1	Chronic	chronic	JJ
cord-015910-d9gxew91	332	2	inflammation	inflammation	NN
cord-015910-d9gxew91	332	3	is	be	VBZ
cord-015910-d9gxew91	332	4	either	either	CC
cord-015910-d9gxew91	332	5	a	a	DT
cord-015910-d9gxew91	332	6	causative	causative	JJ
cord-015910-d9gxew91	332	7	agent	agent	NN
cord-015910-d9gxew91	332	8	or	or	CC
cord-015910-d9gxew91	332	9	a	a	DT
cord-015910-d9gxew91	332	10	closely	closely	RB
cord-015910-d9gxew91	332	11	associated	associated	JJ
cord-015910-d9gxew91	332	12	process	process	NN
cord-015910-d9gxew91	332	13	in	in	IN
cord-015910-d9gxew91	332	14	the	the	DT
cord-015910-d9gxew91	332	15	pathology	pathology	NN
cord-015910-d9gxew91	332	16	of	of	IN
cord-015910-d9gxew91	332	17	obesity	obesity	NN
cord-015910-d9gxew91	332	18	,	,	,
cord-015910-d9gxew91	332	19	insulin	insulin	NN
cord-015910-d9gxew91	332	20	insensitivity	insensitivity	NN
cord-015910-d9gxew91	332	21	,	,	,
cord-015910-d9gxew91	332	22	and	and	CC
cord-015910-d9gxew91	332	23	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	332	24	.	.	.
cord-015910-d9gxew91	333	1	The	the	DT
cord-015910-d9gxew91	333	2	incidence	incidence	NN
cord-015910-d9gxew91	333	3	of	of	IN
cord-015910-d9gxew91	333	4	these	these	DT
cord-015910-d9gxew91	333	5	conditions	condition	NNS
cord-015910-d9gxew91	333	6	increases	increase	VBZ
cord-015910-d9gxew91	333	7	with	with	IN
cord-015910-d9gxew91	333	8	aging	aging	NN
cord-015910-d9gxew91	333	9	.	.	.
cord-015910-d9gxew91	334	1	A	a	DT
cord-015910-d9gxew91	334	2	fundamental	fundamental	JJ
cord-015910-d9gxew91	334	3	question	question	NN
cord-015910-d9gxew91	334	4	is	be	VBZ
cord-015910-d9gxew91	334	5	which	which	WDT
cord-015910-d9gxew91	334	6	precedes	precede	VBZ
cord-015910-d9gxew91	334	7	the	the	DT
cord-015910-d9gxew91	334	8	other	other	JJ
cord-015910-d9gxew91	334	9	-	-	:
cord-015910-d9gxew91	334	10	the	the	DT
cord-015910-d9gxew91	334	11	general	general	JJ
cord-015910-d9gxew91	334	12	increase	increase	NN
cord-015910-d9gxew91	334	13	in	in	IN
cord-015910-d9gxew91	334	14	inflammation	inflammation	NN
cord-015910-d9gxew91	334	15	or	or	CC
cord-015910-d9gxew91	334	16	the	the	DT
cord-015910-d9gxew91	334	17	development	development	NN
cord-015910-d9gxew91	334	18	of	of	IN
cord-015910-d9gxew91	334	19	diseases	disease	NNS
cord-015910-d9gxew91	334	20	with	with	IN
cord-015910-d9gxew91	334	21	overt	overt	JJ
cord-015910-d9gxew91	334	22	and	and	CC
cord-015910-d9gxew91	334	23	covert	covert	JJ
cord-015910-d9gxew91	334	24	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	334	25	bases	basis	NNS
cord-015910-d9gxew91	334	26	?	?	.
cord-015910-d9gxew91	335	1	This	this	DT
cord-015910-d9gxew91	335	2	"	"	``
cord-015910-d9gxew91	335	3	chicken	chicken	NN
cord-015910-d9gxew91	335	4	-	-	HYPH
cord-015910-d9gxew91	335	5	and	and	CC
cord-015910-d9gxew91	335	6	-	-	HYPH
cord-015910-d9gxew91	335	7	egg	egg	NN
cord-015910-d9gxew91	335	8	"	"	''
cord-015910-d9gxew91	335	9	question	question	NN
cord-015910-d9gxew91	335	10	is	be	VBZ
cord-015910-d9gxew91	335	11	difficult	difficult	JJ
cord-015910-d9gxew91	335	12	to	to	TO
cord-015910-d9gxew91	335	13	answer	answer	VB
cord-015910-d9gxew91	335	14	.	.	.
cord-015910-d9gxew91	336	1	However	however	RB
cord-015910-d9gxew91	336	2	,	,	,
cord-015910-d9gxew91	336	3	examination	examination	NN
cord-015910-d9gxew91	336	4	of	of	IN
cord-015910-d9gxew91	336	5	data	datum	NNS
cord-015910-d9gxew91	336	6	from	from	IN
cord-015910-d9gxew91	336	7	studies	study	NNS
cord-015910-d9gxew91	336	8	conducted	conduct	VBN
cord-015910-d9gxew91	336	9	in	in	IN
cord-015910-d9gxew91	336	10	elderly	elderly	JJ
cord-015910-d9gxew91	336	11	populations	population	NNS
cord-015910-d9gxew91	336	12	may	may	MD
cord-015910-d9gxew91	336	13	throw	throw	VB
cord-015910-d9gxew91	336	14	some	some	DT
cord-015910-d9gxew91	336	15	light	light	NN
cord-015910-d9gxew91	336	16	on	on	IN
cord-015910-d9gxew91	336	17	the	the	DT
cord-015910-d9gxew91	336	18	answer	answer	NN
cord-015910-d9gxew91	336	19	to	to	IN
cord-015910-d9gxew91	336	20	this	this	DT
cord-015910-d9gxew91	336	21	conumdrum	conumdrum	NN
cord-015910-d9gxew91	336	22	.	.	.
cord-015910-d9gxew91	337	1	There	there	EX
cord-015910-d9gxew91	337	2	are	be	VBP
cord-015910-d9gxew91	337	3	at	at	RB
cord-015910-d9gxew91	337	4	least	least	RBS
cord-015910-d9gxew91	337	5	two	two	CD
cord-015910-d9gxew91	337	6	potential	potential	JJ
cord-015910-d9gxew91	337	7	mechanisms	mechanism	NNS
cord-015910-d9gxew91	337	8	for	for	IN
cord-015910-d9gxew91	337	9	the	the	DT
cord-015910-d9gxew91	337	10	higher	high	JJR
cord-015910-d9gxew91	337	11	level	level	NN
cord-015910-d9gxew91	337	12	of	of	IN
cord-015910-d9gxew91	337	13	chronic	chronic	JJ
cord-015910-d9gxew91	337	14	inflammation	inflammation	NN
cord-015910-d9gxew91	337	15	observed	observe	VBN
cord-015910-d9gxew91	337	16	in	in	IN
cord-015910-d9gxew91	337	17	elderly	elderly	JJ
cord-015910-d9gxew91	337	18	than	than	IN
cord-015910-d9gxew91	337	19	in	in	IN
cord-015910-d9gxew91	337	20	younger	young	JJR
cord-015910-d9gxew91	337	21	subjects	subject	NNS
cord-015910-d9gxew91	337	22	.	.	.
cord-015910-d9gxew91	338	1	The	the	DT
cord-015910-d9gxew91	338	2	first	first	JJ
cord-015910-d9gxew91	338	3	of	of	IN
cord-015910-d9gxew91	338	4	these	these	DT
cord-015910-d9gxew91	338	5	is	be	VBZ
cord-015910-d9gxew91	338	6	that	that	IN
cord-015910-d9gxew91	338	7	the	the	DT
cord-015910-d9gxew91	338	8	elderly	elderly	JJ
cord-015910-d9gxew91	338	9	are	be	VBP
cord-015910-d9gxew91	338	10	experiencing	experience	VBG
cord-015910-d9gxew91	338	11	a	a	DT
cord-015910-d9gxew91	338	12	higher	high	JJR
cord-015910-d9gxew91	338	13	level	level	NN
cord-015910-d9gxew91	338	14	of	of	IN
cord-015910-d9gxew91	338	15	asymptomatic	asymptomatic	JJ
cord-015910-d9gxew91	338	16	urinary	urinary	JJ
cord-015910-d9gxew91	338	17	infection	infection	NN
cord-015910-d9gxew91	338	18	.	.	.
cord-015910-d9gxew91	339	1	This	this	DT
cord-015910-d9gxew91	339	2	possibility	possibility	NN
cord-015910-d9gxew91	339	3	was	be	VBD
cord-015910-d9gxew91	339	4	studied	study	VBN
cord-015910-d9gxew91	339	5	in	in	IN
cord-015910-d9gxew91	339	6	40	40	CD
cord-015910-d9gxew91	339	7	consecutive	consecutive	JJ
cord-015910-d9gxew91	339	8	patients	patient	NNS
cord-015910-d9gxew91	339	9	(	(	-LRB-
cord-015910-d9gxew91	339	10	70	70	CD
cord-015910-d9gxew91	339	11	-	-	SYM
cord-015910-d9gxew91	339	12	91	91	CD
cord-015910-d9gxew91	339	13	yr	yr	NN
cord-015910-d9gxew91	339	14	)	)	-RRB-
cord-015910-d9gxew91	339	15	admitted	admit	VBD
cord-015910-d9gxew91	339	16	to	to	IN
cord-015910-d9gxew91	339	17	the	the	DT
cord-015910-d9gxew91	339	18	hospital	hospital	NN
cord-015910-d9gxew91	339	19	for	for	IN
cord-015910-d9gxew91	339	20	functional	functional	JJ
cord-015910-d9gxew91	339	21	disability	disability	NN
cord-015910-d9gxew91	339	22	.	.	.
cord-015910-d9gxew91	340	1	Patients	patient	NNS
cord-015910-d9gxew91	340	2	were	be	VBD
cord-015910-d9gxew91	340	3	examined	examine	VBN
cord-015910-d9gxew91	340	4	for	for	IN
cord-015910-d9gxew91	340	5	the	the	DT
cord-015910-d9gxew91	340	6	presence	presence	NN
cord-015910-d9gxew91	340	7	or	or	CC
cord-015910-d9gxew91	340	8	absence	absence	NN
cord-015910-d9gxew91	340	9	of	of	IN
cord-015910-d9gxew91	340	10	bacteria	bacteria	NNS
cord-015910-d9gxew91	340	11	in	in	IN
cord-015910-d9gxew91	340	12	the	the	DT
cord-015910-d9gxew91	340	13	urine	urine	NN
cord-015910-d9gxew91	340	14	.	.	.
cord-015910-d9gxew91	341	1	Twenty	twenty	CD
cord-015910-d9gxew91	341	2	subjects	subject	NNS
cord-015910-d9gxew91	341	3	had	have	VBD
cord-015910-d9gxew91	341	4	a	a	DT
cord-015910-d9gxew91	341	5	positive	positive	JJ
cord-015910-d9gxew91	341	6	urine	urine	NN
cord-015910-d9gxew91	341	7	culture	culture	NN
cord-015910-d9gxew91	341	8	,	,	,
cord-015910-d9gxew91	341	9	and	and	CC
cord-015910-d9gxew91	341	10	20	20	CD
cord-015910-d9gxew91	341	11	sex	sex	NN
cord-015910-d9gxew91	341	12	-	-	HYPH
cord-015910-d9gxew91	341	13	and	and	CC
cord-015910-d9gxew91	341	14	age	age	NN
cord-015910-d9gxew91	341	15	-	-	HYPH
cord-015910-d9gxew91	341	16	matched	match	VBN
cord-015910-d9gxew91	341	17	subjects	subject	NNS
cord-015910-d9gxew91	341	18	had	have	VBD
cord-015910-d9gxew91	341	19	a	a	DT
cord-015910-d9gxew91	341	20	negative	negative	JJ
cord-015910-d9gxew91	341	21	urine	urine	NN
cord-015910-d9gxew91	341	22	culture	culture	NN
cord-015910-d9gxew91	341	23	.	.	.
cord-015910-d9gxew91	342	1	Inclusion	inclusion	NN
cord-015910-d9gxew91	342	2	criteria	criterion	NNS
cord-015910-d9gxew91	342	3	were	be	VBD
cord-015910-d9gxew91	342	4	temperature	temperature	NN
cord-015910-d9gxew91	342	5	<	<	XX
cord-015910-d9gxew91	342	6	37.8	37.8	CD
cord-015910-d9gxew91	342	7	°	°	NN
cord-015910-d9gxew91	342	8	C	C	NNP
cord-015910-d9gxew91	342	9	,	,	,
cord-015910-d9gxew91	342	10	no	no	DT
cord-015910-d9gxew91	342	11	clinical	clinical	JJ
cord-015910-d9gxew91	342	12	signs	sign	NNS
cord-015910-d9gxew91	342	13	of	of	IN
cord-015910-d9gxew91	342	14	infection	infection	NN
cord-015910-d9gxew91	342	15	,	,	,
cord-015910-d9gxew91	342	16	and	and	CC
cord-015910-d9gxew91	342	17	no	no	DT
cord-015910-d9gxew91	342	18	current	current	JJ
cord-015910-d9gxew91	342	19	antibiotic	antibiotic	JJ
cord-015910-d9gxew91	342	20	treatment	treatment	NN
cord-015910-d9gxew91	342	21	.	.	.
cord-015910-d9gxew91	343	1	Patients	patient	NNS
cord-015910-d9gxew91	343	2	with	with	IN
cord-015910-d9gxew91	343	3	asymptomatic	asymptomatic	JJ
cord-015910-d9gxew91	343	4	bacteriuria	bacteriuria	NN
cord-015910-d9gxew91	343	5	had	have	VBD
cord-015910-d9gxew91	343	6	significantly	significantly	RB
cord-015910-d9gxew91	343	7	increased	increase	VBN
cord-015910-d9gxew91	343	8	levels	level	NNS
cord-015910-d9gxew91	343	9	of	of	IN
cord-015910-d9gxew91	343	10	TNF	TNF	NNP
cord-015910-d9gxew91	343	11	receptors	receptor	NNS
cord-015910-d9gxew91	343	12	and	and	CC
cord-015910-d9gxew91	343	13	a	a	DT
cord-015910-d9gxew91	343	14	higher	high	JJR
cord-015910-d9gxew91	343	15	number	number	NN
cord-015910-d9gxew91	343	16	of	of	IN
cord-015910-d9gxew91	343	17	neutrophils	neutrophil	NNS
cord-015910-d9gxew91	343	18	in	in	IN
cord-015910-d9gxew91	343	19	the	the	DT
cord-015910-d9gxew91	343	20	blood	blood	NN
cord-015910-d9gxew91	343	21	compared	compare	VBN
cord-015910-d9gxew91	343	22	to	to	IN
cord-015910-d9gxew91	343	23	the	the	DT
cord-015910-d9gxew91	343	24	group	group	NN
cord-015910-d9gxew91	343	25	without	without	IN
cord-015910-d9gxew91	343	26	bacteriuria	bacteriuria	NNP
cord-015910-d9gxew91	343	27	.	.	.
cord-015910-d9gxew91	344	1	Thus	thus	RB
cord-015910-d9gxew91	344	2	,	,	,
cord-015910-d9gxew91	344	3	the	the	DT
cord-015910-d9gxew91	344	4	study	study	NN
cord-015910-d9gxew91	344	5	provides	provide	VBZ
cord-015910-d9gxew91	344	6	some	some	DT
cord-015910-d9gxew91	344	7	support	support	NN
cord-015910-d9gxew91	344	8	for	for	IN
cord-015910-d9gxew91	344	9	the	the	DT
cord-015910-d9gxew91	344	10	hypothesis	hypothesis	NN
cord-015910-d9gxew91	344	11	that	that	IN
cord-015910-d9gxew91	344	12	asymptomatic	asymptomatic	JJ
cord-015910-d9gxew91	344	13	urinary	urinary	JJ
cord-015910-d9gxew91	344	14	infections	infection	NNS
cord-015910-d9gxew91	344	15	are	be	VBP
cord-015910-d9gxew91	344	16	associated	associate	VBN
cord-015910-d9gxew91	344	17	with	with	IN
cord-015910-d9gxew91	344	18	low	low	JJ
cord-015910-d9gxew91	344	19	-	-	HYPH
cord-015910-d9gxew91	344	20	grade	grade	NN
cord-015910-d9gxew91	344	21	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	344	22	activity	activity	NN
cord-015910-d9gxew91	344	23	in	in	IN
cord-015910-d9gxew91	344	24	frail	frail	JJ
cord-015910-d9gxew91	344	25	,	,	,
cord-015910-d9gxew91	344	26	elderly	elderly	JJ
cord-015910-d9gxew91	344	27	subjects	subject	NNS
cord-015910-d9gxew91	344	28	(	(	-LRB-
cord-015910-d9gxew91	344	29	Prio	Prio	NNP
cord-015910-d9gxew91	344	30	,	,	,
cord-015910-d9gxew91	344	31	Bruunsgaard	Bruunsgaard	NNP
cord-015910-d9gxew91	344	32	,	,	,
cord-015910-d9gxew91	344	33	Roge	Roge	NNP
cord-015910-d9gxew91	344	34	,	,	,
cord-015910-d9gxew91	344	35	&	&	CC
cord-015910-d9gxew91	344	36	Pedersen	Pedersen	NNP
cord-015910-d9gxew91	344	37	,	,	,
cord-015910-d9gxew91	344	38	2002	2002	CD
cord-015910-d9gxew91	344	39	)	)	-RRB-
cord-015910-d9gxew91	344	40	.	.	.
cord-015910-d9gxew91	345	1	A	a	DT
cord-015910-d9gxew91	345	2	second	second	JJ
cord-015910-d9gxew91	345	3	potential	potential	JJ
cord-015910-d9gxew91	345	4	mechanism	mechanism	NN
cord-015910-d9gxew91	345	5	resides	reside	VBZ
cord-015910-d9gxew91	345	6	in	in	IN
cord-015910-d9gxew91	345	7	endocrine	endocrine	JJ
cord-015910-d9gxew91	345	8	changes	change	NNS
cord-015910-d9gxew91	345	9	during	during	IN
cord-015910-d9gxew91	345	10	aging	age	VBG
cord-015910-d9gxew91	345	11	.	.	.
cord-015910-d9gxew91	346	1	In	in	IN
cord-015910-d9gxew91	346	2	aging	age	VBG
cord-015910-d9gxew91	346	3	,	,	,
cord-015910-d9gxew91	346	4	dysregulation	dysregulation	NN
cord-015910-d9gxew91	346	5	of	of	IN
cord-015910-d9gxew91	346	6	secretion	secretion	NN
cord-015910-d9gxew91	346	7	of	of	IN
cord-015910-d9gxew91	346	8	hormones	hormone	NNS
cord-015910-d9gxew91	346	9	that	that	WDT
cord-015910-d9gxew91	346	10	come	come	VBP
cord-015910-d9gxew91	346	11	under	under	IN
cord-015910-d9gxew91	346	12	the	the	DT
cord-015910-d9gxew91	346	13	regulation	regulation	NN
cord-015910-d9gxew91	346	14	of	of	IN
cord-015910-d9gxew91	346	15	the	the	DT
cord-015910-d9gxew91	346	16	hypothalamic	hypothalamic	JJ
cord-015910-d9gxew91	346	17	-	-	HYPH
cord-015910-d9gxew91	346	18	pituitary	pituitary	NN
cord-015910-d9gxew91	346	19	-	-	HYPH
cord-015910-d9gxew91	346	20	adrenal	adrenal	NN
cord-015910-d9gxew91	346	21	axis	axis	NN
cord-015910-d9gxew91	346	22	may	may	MD
cord-015910-d9gxew91	346	23	occur	occur	VB
cord-015910-d9gxew91	346	24	.	.	.
cord-015910-d9gxew91	347	1	This	this	DT
cord-015910-d9gxew91	347	2	may	may	MD
cord-015910-d9gxew91	347	3	have	have	VB
cord-015910-d9gxew91	347	4	an	an	DT
cord-015910-d9gxew91	347	5	effect	effect	NN
cord-015910-d9gxew91	347	6	on	on	IN
cord-015910-d9gxew91	347	7	the	the	DT
cord-015910-d9gxew91	347	8	regulation	regulation	NN
cord-015910-d9gxew91	347	9	of	of	IN
cord-015910-d9gxew91	347	10	cortisol	cortisol	NN
cord-015910-d9gxew91	347	11	secretion	secretion	NN
cord-015910-d9gxew91	347	12	,	,	,
cord-015910-d9gxew91	347	13	as	as	IN
cord-015910-d9gxew91	347	14	mentioned	mention	VBN
cord-015910-d9gxew91	347	15	earlier	early	RBR
cord-015910-d9gxew91	347	16	.	.	.
cord-015910-d9gxew91	348	1	Cortisol	cortisol	NN
cord-015910-d9gxew91	348	2	is	be	VBZ
cord-015910-d9gxew91	348	3	important	important	JJ
cord-015910-d9gxew91	348	4	as	as	IN
cord-015910-d9gxew91	348	5	an	an	DT
cord-015910-d9gxew91	348	6	anti	anti	JJ
cord-015910-d9gxew91	348	7	-	-	JJ
cord-015910-d9gxew91	348	8	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	348	9	agent	agent	NN
cord-015910-d9gxew91	348	10	.	.	.
cord-015910-d9gxew91	349	1	The	the	DT
cord-015910-d9gxew91	349	2	effect	effect	NN
cord-015910-d9gxew91	349	3	of	of	IN
cord-015910-d9gxew91	349	4	aging	age	VBG
cord-015910-d9gxew91	349	5	on	on	IN
cord-015910-d9gxew91	349	6	glucocorticoid	glucocorticoid	NN
cord-015910-d9gxew91	349	7	sensitivity	sensitivity	NN
cord-015910-d9gxew91	349	8	of	of	IN
cord-015910-d9gxew91	349	9	pro	pro	JJ
cord-015910-d9gxew91	349	10	-	-	JJ
cord-015910-d9gxew91	349	11	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	349	12	cytokine	cytokine	NN
cord-015910-d9gxew91	349	13	production	production	NN
cord-015910-d9gxew91	349	14	was	be	VBD
cord-015910-d9gxew91	349	15	examined	examine	VBN
cord-015910-d9gxew91	349	16	in	in	IN
cord-015910-d9gxew91	349	17	elderly	elderly	JJ
cord-015910-d9gxew91	349	18	men	man	NNS
cord-015910-d9gxew91	349	19	,	,	,
cord-015910-d9gxew91	349	20	testosterone	testosterone	NN
cord-015910-d9gxew91	349	21	-	-	HYPH
cord-015910-d9gxew91	349	22	treated	treat	VBN
cord-015910-d9gxew91	349	23	elderly	elderly	JJ
cord-015910-d9gxew91	349	24	men	man	NNS
cord-015910-d9gxew91	349	25	,	,	,
cord-015910-d9gxew91	349	26	and	and	CC
cord-015910-d9gxew91	349	27	young	young	JJ
cord-015910-d9gxew91	349	28	controls	control	NNS
cord-015910-d9gxew91	349	29	.	.	.
cord-015910-d9gxew91	350	1	Stress	stress	NN
cord-015910-d9gxew91	350	2	-	-	HYPH
cord-015910-d9gxew91	350	3	induced	induce	VBN
cord-015910-d9gxew91	350	4	increases	increase	NNS
cord-015910-d9gxew91	350	5	in	in	IN
cord-015910-d9gxew91	350	6	cortisol	cortisol	NN
cord-015910-d9gxew91	350	7	did	do	VBD
cord-015910-d9gxew91	350	8	not	not	RB
cord-015910-d9gxew91	350	9	differ	differ	VB
cord-015910-d9gxew91	350	10	significantly	significantly	RB
cord-015910-d9gxew91	350	11	between	between	IN
cord-015910-d9gxew91	350	12	experimental	experimental	JJ
cord-015910-d9gxew91	350	13	groups	group	NNS
cord-015910-d9gxew91	350	14	,	,	,
cord-015910-d9gxew91	350	15	but	but	CC
cord-015910-d9gxew91	350	16	glucocorticoid	glucocorticoid	NN
cord-015910-d9gxew91	350	17	sensitivity	sensitivity	NN
cord-015910-d9gxew91	350	18	increased	increase	VBD
cord-015910-d9gxew91	350	19	significantly	significantly	RB
cord-015910-d9gxew91	350	20	in	in	IN
cord-015910-d9gxew91	350	21	young	young	JJ
cord-015910-d9gxew91	350	22	controls	control	NNS
cord-015910-d9gxew91	350	23	and	and	CC
cord-015910-d9gxew91	350	24	testosterone	testosterone	NN
cord-015910-d9gxew91	350	25	-	-	HYPH
cord-015910-d9gxew91	350	26	treated	treat	VBN
cord-015910-d9gxew91	350	27	elderly	elderly	JJ
cord-015910-d9gxew91	350	28	men	man	NNS
cord-015910-d9gxew91	350	29	,	,	,
cord-015910-d9gxew91	350	30	whereas	whereas	IN
cord-015910-d9gxew91	350	31	a	a	DT
cord-015910-d9gxew91	350	32	decrease	decrease	NN
cord-015910-d9gxew91	350	33	was	be	VBD
cord-015910-d9gxew91	350	34	found	find	VBN
cord-015910-d9gxew91	350	35	in	in	IN
cord-015910-d9gxew91	350	36	untreated	untreated	JJ
cord-015910-d9gxew91	350	37	elderly	elderly	JJ
cord-015910-d9gxew91	350	38	men	man	NNS
cord-015910-d9gxew91	350	39	.	.	.
cord-015910-d9gxew91	351	1	As	as	IN
cord-015910-d9gxew91	351	2	the	the	DT
cord-015910-d9gxew91	351	3	increase	increase	NN
cord-015910-d9gxew91	351	4	in	in	IN
cord-015910-d9gxew91	351	5	glucocorticoid	glucocorticoid	NN
cord-015910-d9gxew91	351	6	sensitivity	sensitivity	NN
cord-015910-d9gxew91	351	7	after	after	IN
cord-015910-d9gxew91	351	8	stress	stress	NN
cord-015910-d9gxew91	351	9	serves	serve	VBZ
cord-015910-d9gxew91	351	10	to	to	TO
cord-015910-d9gxew91	351	11	protect	protect	VB
cord-015910-d9gxew91	351	12	the	the	DT
cord-015910-d9gxew91	351	13	individual	individual	NN
cord-015910-d9gxew91	351	14	from	from	IN
cord-015910-d9gxew91	351	15	detrimental	detrimental	JJ
cord-015910-d9gxew91	351	16	increases	increase	NNS
cord-015910-d9gxew91	351	17	of	of	IN
cord-015910-d9gxew91	351	18	pro	pro	JJ
cord-015910-d9gxew91	351	19	-	-	JJ
cord-015910-d9gxew91	351	20	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	351	21	cytokines	cytokine	NNS
cord-015910-d9gxew91	351	22	,	,	,
cord-015910-d9gxew91	351	23	the	the	DT
cord-015910-d9gxew91	351	24	disturbed	disturbed	JJ
cord-015910-d9gxew91	351	25	mechanism	mechanism	NN
cord-015910-d9gxew91	351	26	in	in	IN
cord-015910-d9gxew91	351	27	elderly	elderly	JJ
cord-015910-d9gxew91	351	28	men	man	NNS
cord-015910-d9gxew91	351	29	may	may	MD
cord-015910-d9gxew91	351	30	result	result	VB
cord-015910-d9gxew91	351	31	in	in	IN
cord-015910-d9gxew91	351	32	an	an	DT
cord-015910-d9gxew91	351	33	increase	increase	NN
cord-015910-d9gxew91	351	34	in	in	IN
cord-015910-d9gxew91	351	35	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	351	36	stress	stress	NN
cord-015910-d9gxew91	351	37	(	(	-LRB-
cord-015910-d9gxew91	351	38	Rohleder	Rohleder	NNP
cord-015910-d9gxew91	351	39	,	,	,
cord-015910-d9gxew91	351	40	Kudielka	Kudielka	NNP
cord-015910-d9gxew91	351	41	,	,	,
cord-015910-d9gxew91	351	42	Hellhammer	Hellhammer	NNP
cord-015910-d9gxew91	351	43	,	,	,
cord-015910-d9gxew91	351	44	Wolf	Wolf	NNP
cord-015910-d9gxew91	351	45	,	,	,
cord-015910-d9gxew91	351	46	&	&	CC
cord-015910-d9gxew91	351	47	Kirschbaum	Kirschbaum	NNP
cord-015910-d9gxew91	351	48	,	,	,
cord-015910-d9gxew91	351	49	2002	2002	CD
cord-015910-d9gxew91	351	50	)	)	-RRB-
cord-015910-d9gxew91	351	51	.	.	.
cord-015910-d9gxew91	352	1	There	there	EX
cord-015910-d9gxew91	352	2	is	be	VBZ
cord-015910-d9gxew91	352	3	now	now	RB
cord-015910-d9gxew91	352	4	a	a	DT
cord-015910-d9gxew91	352	5	large	large	JJ
cord-015910-d9gxew91	352	6	body	body	NN
cord-015910-d9gxew91	352	7	of	of	IN
cord-015910-d9gxew91	352	8	evidence	evidence	NN
cord-015910-d9gxew91	352	9	suggesting	suggest	VBG
cord-015910-d9gxew91	352	10	that	that	IN
cord-015910-d9gxew91	352	11	the	the	DT
cord-015910-d9gxew91	352	12	decline	decline	NN
cord-015910-d9gxew91	352	13	in	in	IN
cord-015910-d9gxew91	352	14	ovarian	ovarian	JJ
cord-015910-d9gxew91	352	15	function	function	NN
cord-015910-d9gxew91	352	16	with	with	IN
cord-015910-d9gxew91	352	17	menopause	menopause	NN
cord-015910-d9gxew91	352	18	is	be	VBZ
cord-015910-d9gxew91	352	19	associated	associate	VBN
cord-015910-d9gxew91	352	20	with	with	IN
cord-015910-d9gxew91	352	21	spontaneous	spontaneous	JJ
cord-015910-d9gxew91	352	22	increases	increase	NNS
cord-015910-d9gxew91	352	23	in	in	IN
cord-015910-d9gxew91	352	24	pro	pro	JJ
cord-015910-d9gxew91	352	25	-	-	JJ
cord-015910-d9gxew91	352	26	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	352	27	cytokine	cytokine	NN
cord-015910-d9gxew91	352	28	production	production	NN
cord-015910-d9gxew91	352	29	.	.	.
cord-015910-d9gxew91	353	1	As	as	IN
cord-015910-d9gxew91	353	2	mentioned	mention	VBN
cord-015910-d9gxew91	353	3	earlier	early	RBR
cord-015910-d9gxew91	353	4	,	,	,
cord-015910-d9gxew91	353	5	studies	study	NNS
cord-015910-d9gxew91	353	6	in	in	IN
cord-015910-d9gxew91	353	7	men	man	NNS
cord-015910-d9gxew91	353	8	and	and	CC
cord-015910-d9gxew91	353	9	postmenopausal	postmenopausal	JJ
cord-015910-d9gxew91	353	10	women	woman	NNS
cord-015910-d9gxew91	353	11	indicate	indicate	VBP
cord-015910-d9gxew91	353	12	a	a	DT
cord-015910-d9gxew91	353	13	remarkable	remarkable	JJ
cord-015910-d9gxew91	353	14	individual	individual	JJ
cord-015910-d9gxew91	353	15	constancy	constancy	NN
cord-015910-d9gxew91	353	16	in	in	IN
cord-015910-d9gxew91	353	17	the	the	DT
cord-015910-d9gxew91	353	18	ability	ability	NN
cord-015910-d9gxew91	353	19	of	of	IN
cord-015910-d9gxew91	353	20	PBMCs	pbmc	NNS
cord-015910-d9gxew91	353	21	to	to	TO
cord-015910-d9gxew91	353	22	produce	produce	VB
cord-015910-d9gxew91	353	23	TNF	TNF	NNP
cord-015910-d9gxew91	353	24	-	-	HYPH
cord-015910-d9gxew91	353	25	cz	cz	NNP
cord-015910-d9gxew91	353	26	ex	ex	FW
cord-015910-d9gxew91	353	27	vivo	vivo	NN
cord-015910-d9gxew91	353	28	,	,	,
cord-015910-d9gxew91	353	29	and	and	CC
cord-015910-d9gxew91	353	30	genetic	genetic	JJ
cord-015910-d9gxew91	353	31	determinants	determinant	NNS
cord-015910-d9gxew91	353	32	underlie	underlie	VBP
cord-015910-d9gxew91	353	33	this	this	DT
cord-015910-d9gxew91	353	34	constancy	constancy	NN
cord-015910-d9gxew91	353	35	.	.	.
cord-015910-d9gxew91	354	1	However	however	RB
cord-015910-d9gxew91	354	2	in	in	IN
cord-015910-d9gxew91	354	3	premenopausal	premenopausal	JJ
cord-015910-d9gxew91	354	4	women	woman	NNS
cord-015910-d9gxew91	354	5	production	production	NN
cord-015910-d9gxew91	354	6	is	be	VBZ
cord-015910-d9gxew91	354	7	highly	highly	RB
cord-015910-d9gxew91	354	8	variable	variable	JJ
cord-015910-d9gxew91	354	9	at	at	IN
cord-015910-d9gxew91	354	10	an	an	DT
cord-015910-d9gxew91	354	11	individual	individual	JJ
cord-015910-d9gxew91	354	12	level	level	NN
cord-015910-d9gxew91	354	13	,	,	,
cord-015910-d9gxew91	354	14	indicating	indicate	VBG
cord-015910-d9gxew91	354	15	how	how	WRB
cord-015910-d9gxew91	354	16	ovarian	ovarian	JJ
cord-015910-d9gxew91	354	17	hormones	hormone	NNS
cord-015910-d9gxew91	354	18	are	be	VBP
cord-015910-d9gxew91	354	19	able	able	JJ
cord-015910-d9gxew91	354	20	to	to	TO
cord-015910-d9gxew91	354	21	override	override	VB
cord-015910-d9gxew91	354	22	the	the	DT
cord-015910-d9gxew91	354	23	influence	influence	NN
cord-015910-d9gxew91	354	24	of	of	IN
cord-015910-d9gxew91	354	25	genotype	genotype	NN
cord-015910-d9gxew91	354	26	(	(	-LRB-
cord-015910-d9gxew91	354	27	Jacob	Jacob	NNP
cord-015910-d9gxew91	354	28	et	et	NNP
cord-015910-d9gxew91	354	29	al	al	NNP
cord-015910-d9gxew91	354	30	.	.	NNP
cord-015910-d9gxew91	354	31	,	,	,
cord-015910-d9gxew91	354	32	1990	1990	CD
cord-015910-d9gxew91	354	33	)	)	-RRB-
cord-015910-d9gxew91	354	34	.	.	.
cord-015910-d9gxew91	355	1	The	the	DT
cord-015910-d9gxew91	355	2	exact	exact	JJ
cord-015910-d9gxew91	355	3	mechanisms	mechanism	NNS
cord-015910-d9gxew91	355	4	by	by	IN
cord-015910-d9gxew91	355	5	which	which	WDT
cord-015910-d9gxew91	355	6	estrogen	estrogen	NN
cord-015910-d9gxew91	355	7	interferes	interfere	VBZ
cord-015910-d9gxew91	355	8	with	with	IN
cord-015910-d9gxew91	355	9	cytokine	cytokine	NN
cord-015910-d9gxew91	355	10	activity	activity	NN
cord-015910-d9gxew91	355	11	are	be	VBP
cord-015910-d9gxew91	355	12	still	still	RB
cord-015910-d9gxew91	355	13	incompletely	incompletely	RB
cord-015910-d9gxew91	355	14	known	known	JJ
cord-015910-d9gxew91	355	15	but	but	CC
cord-015910-d9gxew91	355	16	may	may	MD
cord-015910-d9gxew91	355	17	include	include	VB
cord-015910-d9gxew91	355	18	interactions	interaction	NNS
cord-015910-d9gxew91	355	19	of	of	IN
cord-015910-d9gxew91	355	20	the	the	DT
cord-015910-d9gxew91	355	21	estrogen	estrogen	NN
cord-015910-d9gxew91	355	22	receptor	receptor	NN
cord-015910-d9gxew91	355	23	with	with	IN
cord-015910-d9gxew91	355	24	other	other	JJ
cord-015910-d9gxew91	355	25	transcription	transcription	NN
cord-015910-d9gxew91	355	26	factors	factor	NNS
cord-015910-d9gxew91	355	27	,	,	,
cord-015910-d9gxew91	355	28	modulation	modulation	NN
cord-015910-d9gxew91	355	29	of	of	IN
cord-015910-d9gxew91	355	30	nitric	nitric	NN
cord-015910-d9gxew91	355	31	oxide	oxide	NN
cord-015910-d9gxew91	355	32	activity	activity	NN
cord-015910-d9gxew91	355	33	,	,	,
cord-015910-d9gxew91	355	34	antioxidative	antioxidative	JJ
cord-015910-d9gxew91	355	35	effects	effect	NNS
cord-015910-d9gxew91	355	36	,	,	,
cord-015910-d9gxew91	355	37	plasma	plasma	NN
cord-015910-d9gxew91	355	38	membrane	membrane	NN
cord-015910-d9gxew91	355	39	actions	action	NNS
cord-015910-d9gxew91	355	40	,	,	,
cord-015910-d9gxew91	355	41	and	and	CC
cord-015910-d9gxew91	355	42	changes	change	NNS
cord-015910-d9gxew91	355	43	in	in	IN
cord-015910-d9gxew91	355	44	immune	immune	JJ
cord-015910-d9gxew91	355	45	cell	cell	NN
cord-015910-d9gxew91	355	46	function	function	NN
cord-015910-d9gxew91	355	47	.	.	.
cord-015910-d9gxew91	356	1	Experimental	experimental	JJ
cord-015910-d9gxew91	356	2	and	and	CC
cord-015910-d9gxew91	356	3	clinical	clinical	JJ
cord-015910-d9gxew91	356	4	studies	study	NNS
cord-015910-d9gxew91	356	5	also	also	RB
cord-015910-d9gxew91	356	6	strongly	strongly	RB
cord-015910-d9gxew91	356	7	support	support	VBP
cord-015910-d9gxew91	356	8	a	a	DT
cord-015910-d9gxew91	356	9	link	link	NN
cord-015910-d9gxew91	356	10	between	between	IN
cord-015910-d9gxew91	356	11	the	the	DT
cord-015910-d9gxew91	356	12	increased	increase	VBN
cord-015910-d9gxew91	356	13	state	state	NN
cord-015910-d9gxew91	356	14	of	of	IN
cord-015910-d9gxew91	356	15	pro	pro	JJ
cord-015910-d9gxew91	356	16	-	-	JJ
cord-015910-d9gxew91	356	17	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	356	18	cytokine	cytokine	NN
cord-015910-d9gxew91	356	19	activity	activity	NN
cord-015910-d9gxew91	356	20	and	and	CC
cord-015910-d9gxew91	356	21	postmenopausal	postmenopausal	JJ
cord-015910-d9gxew91	356	22	bone	bone	NN
cord-015910-d9gxew91	356	23	loss	loss	NN
cord-015910-d9gxew91	356	24	(	(	-LRB-
cord-015910-d9gxew91	356	25	Pfeilschifter	Pfeilschifter	NNP
cord-015910-d9gxew91	356	26	et	et	FW
cord-015910-d9gxew91	356	27	al	al	NNP
cord-015910-d9gxew91	356	28	.	.	NNP
cord-015910-d9gxew91	356	29	,	,	,
cord-015910-d9gxew91	356	30	2002	2002	CD
cord-015910-d9gxew91	356	31	)	)	-RRB-
cord-015910-d9gxew91	356	32	.	.	.
cord-015910-d9gxew91	357	1	Recent	recent	JJ
cord-015910-d9gxew91	357	2	evidence	evidence	NN
cord-015910-d9gxew91	357	3	indicates	indicate	VBZ
cord-015910-d9gxew91	357	4	the	the	DT
cord-015910-d9gxew91	357	5	presence	presence	NN
cord-015910-d9gxew91	357	6	of	of	IN
cord-015910-d9gxew91	357	7	SNPs	SNPs	NNP
cord-015910-d9gxew91	357	8	,	,	,
cord-015910-d9gxew91	357	9	associated	associate	VBN
cord-015910-d9gxew91	357	10	with	with	IN
cord-015910-d9gxew91	357	11	the	the	DT
cord-015910-d9gxew91	357	12	strength	strength	NN
cord-015910-d9gxew91	357	13	of	of	IN
cord-015910-d9gxew91	357	14	the	the	DT
cord-015910-d9gxew91	357	15	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	357	16	response	response	NN
cord-015910-d9gxew91	357	17	,	,	,
cord-015910-d9gxew91	357	18	affects	affect	VBZ
cord-015910-d9gxew91	357	19	longevity	longevity	NN
cord-015910-d9gxew91	357	20	.	.	.
cord-015910-d9gxew91	358	1	Human	human	JJ
cord-015910-d9gxew91	358	2	longevity	longevity	NN
cord-015910-d9gxew91	358	3	may	may	MD
cord-015910-d9gxew91	358	4	be	be	VB
cord-015910-d9gxew91	358	5	directly	directly	RB
cord-015910-d9gxew91	358	6	correlated	correlate	VBN
cord-015910-d9gxew91	358	7	with	with	IN
cord-015910-d9gxew91	358	8	optimal	optimal	JJ
cord-015910-d9gxew91	358	9	functioning	functioning	NN
cord-015910-d9gxew91	358	10	of	of	IN
cord-015910-d9gxew91	358	11	the	the	DT
cord-015910-d9gxew91	358	12	immune	immune	JJ
cord-015910-d9gxew91	358	13	system	system	NN
cord-015910-d9gxew91	358	14	.	.	.
cord-015910-d9gxew91	359	1	Therefore	therefore	RB
cord-015910-d9gxew91	359	2	,	,	,
cord-015910-d9gxew91	359	3	it	-PRON-	PRP
cord-015910-d9gxew91	359	4	is	be	VBZ
cord-015910-d9gxew91	359	5	likely	likely	JJ
cord-015910-d9gxew91	359	6	that	that	IN
cord-015910-d9gxew91	359	7	one	one	CD
cord-015910-d9gxew91	359	8	of	of	IN
cord-015910-d9gxew91	359	9	the	the	DT
cord-015910-d9gxew91	359	10	genetic	genetic	JJ
cord-015910-d9gxew91	359	11	determinants	determinant	NNS
cord-015910-d9gxew91	359	12	of	of	IN
cord-015910-d9gxew91	359	13	longevity	longevity	NN
cord-015910-d9gxew91	359	14	resides	reside	VBZ
cord-015910-d9gxew91	359	15	in	in	IN
cord-015910-d9gxew91	359	16	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	359	17	for	for	IN
cord-015910-d9gxew91	359	18	genes	gene	NNS
cord-015910-d9gxew91	359	19	influencing	influence	VBG
cord-015910-d9gxew91	359	20	the	the	DT
cord-015910-d9gxew91	359	21	activity	activity	NN
cord-015910-d9gxew91	359	22	of	of	IN
cord-015910-d9gxew91	359	23	the	the	DT
cord-015910-d9gxew91	359	24	immune	immune	JJ
cord-015910-d9gxew91	359	25	system	system	NN
cord-015910-d9gxew91	359	26	.	.	.
cord-015910-d9gxew91	360	1	It	-PRON-	PRP
cord-015910-d9gxew91	360	2	has	have	VBZ
cord-015910-d9gxew91	360	3	been	be	VBN
cord-015910-d9gxew91	360	4	estimated	estimate	VBN
cord-015910-d9gxew91	360	5	that	that	IN
cord-015910-d9gxew91	360	6	up	up	IN
cord-015910-d9gxew91	360	7	to	to	TO
cord-015910-d9gxew91	360	8	7000	7000	CD
cord-015910-d9gxew91	360	9	variations	variation	NNS
cord-015910-d9gxew91	360	10	in	in	IN
cord-015910-d9gxew91	360	11	the	the	DT
cord-015910-d9gxew91	360	12	genome	genome	NN
cord-015910-d9gxew91	360	13	contribute	contribute	VBP
cord-015910-d9gxew91	360	14	to	to	IN
cord-015910-d9gxew91	360	15	life	life	NN
cord-015910-d9gxew91	360	16	span	span	NN
cord-015910-d9gxew91	360	17	(	(	-LRB-
cord-015910-d9gxew91	360	18	Martin	Martin	NNP
cord-015910-d9gxew91	360	19	,	,	,
cord-015910-d9gxew91	360	20	1997	1997	CD
cord-015910-d9gxew91	360	21	)	)	-RRB-
cord-015910-d9gxew91	360	22	.	.	.
cord-015910-d9gxew91	361	1	Those	those	DT
cord-015910-d9gxew91	361	2	contributing	contribute	VBG
cord-015910-d9gxew91	361	3	to	to	IN
cord-015910-d9gxew91	361	4	loss	loss	NN
cord-015910-d9gxew91	361	5	of	of	IN
cord-015910-d9gxew91	361	6	muscle	muscle	NN
cord-015910-d9gxew91	361	7	and	and	CC
cord-015910-d9gxew91	361	8	bone	bone	NN
cord-015910-d9gxew91	361	9	mass	mass	NN
cord-015910-d9gxew91	361	10	during	during	IN
cord-015910-d9gxew91	361	11	aging	aging	NN
cord-015910-d9gxew91	361	12	are	be	VBP
cord-015910-d9gxew91	361	13	related	relate	VBN
cord-015910-d9gxew91	361	14	to	to	IN
cord-015910-d9gxew91	361	15	the	the	DT
cord-015910-d9gxew91	361	16	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	361	17	process	process	NN
cord-015910-d9gxew91	361	18	and	and	CC
cord-015910-d9gxew91	361	19	include	include	VBP
cord-015910-d9gxew91	361	20	pro	pro	JJ
cord-015910-d9gxew91	361	21	-	-	JJ
cord-015910-d9gxew91	361	22	and	and	CC
cord-015910-d9gxew91	361	23	anti	anti	JJ
cord-015910-d9gxew91	361	24	-	-	JJ
cord-015910-d9gxew91	361	25	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	361	26	cytokines	cytokine	NNS
cord-015910-d9gxew91	361	27	and	and	CC
cord-015910-d9gxew91	361	28	their	-PRON-	PRP$
cord-015910-d9gxew91	361	29	receptors	receptor	NNS
cord-015910-d9gxew91	361	30	.	.	.
cord-015910-d9gxew91	362	1	Studies	study	NNS
cord-015910-d9gxew91	362	2	in	in	IN
cord-015910-d9gxew91	362	3	mice	mouse	NNS
cord-015910-d9gxew91	362	4	have	have	VBP
cord-015910-d9gxew91	362	5	shown	show	VBN
cord-015910-d9gxew91	362	6	that	that	IN
cord-015910-d9gxew91	362	7	the	the	DT
cord-015910-d9gxew91	362	8	genes	gene	NNS
cord-015910-d9gxew91	362	9	controlling	control	VBG
cord-015910-d9gxew91	362	10	the	the	DT
cord-015910-d9gxew91	362	11	major	major	JJ
cord-015910-d9gxew91	362	12	histocompatibility	histocompatibility	NN
cord-015910-d9gxew91	362	13	complex	complex	NN
cord-015910-d9gxew91	362	14	(	(	-LRB-
cord-015910-d9gxew91	362	15	MHC	MHC	NNP
cord-015910-d9gxew91	362	16	)	)	-RRB-
cord-015910-d9gxew91	362	17	,	,	,
cord-015910-d9gxew91	362	18	known	know	VBN
cord-015910-d9gxew91	362	19	to	to	TO
cord-015910-d9gxew91	362	20	control	control	VB
cord-015910-d9gxew91	362	21	a	a	DT
cord-015910-d9gxew91	362	22	variety	variety	NN
cord-015910-d9gxew91	362	23	of	of	IN
cord-015910-d9gxew91	362	24	immune	immune	JJ
cord-015910-d9gxew91	362	25	functions	function	NNS
cord-015910-d9gxew91	362	26	,	,	,
cord-015910-d9gxew91	362	27	are	be	VBP
cord-015910-d9gxew91	362	28	associated	associate	VBN
cord-015910-d9gxew91	362	29	with	with	IN
cord-015910-d9gxew91	362	30	differences	difference	NNS
cord-015910-d9gxew91	362	31	in	in	IN
cord-015910-d9gxew91	362	32	the	the	DT
cord-015910-d9gxew91	362	33	life	life	NN
cord-015910-d9gxew91	362	34	span	span	NN
cord-015910-d9gxew91	362	35	of	of	IN
cord-015910-d9gxew91	362	36	different	different	JJ
cord-015910-d9gxew91	362	37	strains	strain	NNS
cord-015910-d9gxew91	362	38	of	of	IN
cord-015910-d9gxew91	362	39	mice	mouse	NNS
cord-015910-d9gxew91	362	40	,	,	,
cord-015910-d9gxew91	362	41	but	but	CC
cord-015910-d9gxew91	362	42	a	a	DT
cord-015910-d9gxew91	362	43	major	major	JJ
cord-015910-d9gxew91	362	44	difference	difference	NN
cord-015910-d9gxew91	362	45	between	between	IN
cord-015910-d9gxew91	362	46	observations	observation	NNS
cord-015910-d9gxew91	362	47	in	in	IN
cord-015910-d9gxew91	362	48	mice	mouse	NNS
cord-015910-d9gxew91	362	49	and	and	CC
cord-015910-d9gxew91	362	50	humans	human	NNS
cord-015910-d9gxew91	362	51	is	be	VBZ
cord-015910-d9gxew91	362	52	that	that	IN
cord-015910-d9gxew91	362	53	the	the	DT
cord-015910-d9gxew91	362	54	latter	latter	JJ
cord-015910-d9gxew91	362	55	have	have	VBP
cord-015910-d9gxew91	362	56	a	a	DT
cord-015910-d9gxew91	362	57	lifetime	lifetime	NN
cord-015910-d9gxew91	362	58	experience	experience	NN
cord-015910-d9gxew91	362	59	of	of	IN
cord-015910-d9gxew91	362	60	exposure	exposure	NN
cord-015910-d9gxew91	362	61	to	to	IN
cord-015910-d9gxew91	362	62	pathogens	pathogen	NNS
cord-015910-d9gxew91	362	63	,	,	,
cord-015910-d9gxew91	362	64	whereas	whereas	IN
cord-015910-d9gxew91	362	65	for	for	IN
cord-015910-d9gxew91	362	66	laboratory	laboratory	NN
cord-015910-d9gxew91	362	67	animals	animal	NNS
cord-015910-d9gxew91	362	68	this	this	DT
cord-015910-d9gxew91	362	69	exposure	exposure	NN
cord-015910-d9gxew91	362	70	is	be	VBZ
cord-015910-d9gxew91	362	71	kept	keep	VBN
cord-015910-d9gxew91	362	72	to	to	IN
cord-015910-d9gxew91	362	73	a	a	DT
cord-015910-d9gxew91	362	74	minimum	minimum	NN
cord-015910-d9gxew91	362	75	.	.	.
cord-015910-d9gxew91	363	1	Thus	thus	RB
cord-015910-d9gxew91	363	2	,	,	,
cord-015910-d9gxew91	363	3	although	although	IN
cord-015910-d9gxew91	363	4	HLA	HLA	NNP
cord-015910-d9gxew91	363	5	studies	study	NNS
cord-015910-d9gxew91	363	6	in	in	IN
cord-015910-d9gxew91	363	7	mice	mouse	NNS
cord-015910-d9gxew91	363	8	of	of	IN
cord-015910-d9gxew91	363	9	different	different	JJ
cord-015910-d9gxew91	363	10	genotypes	genotype	NNS
cord-015910-d9gxew91	363	11	may	may	MD
cord-015910-d9gxew91	363	12	be	be	VB
cord-015910-d9gxew91	363	13	interpreted	interpret	VBN
cord-015910-d9gxew91	363	14	to	to	TO
cord-015910-d9gxew91	363	15	support	support	VB
cord-015910-d9gxew91	363	16	studies	study	NNS
cord-015910-d9gxew91	363	17	of	of	IN
cord-015910-d9gxew91	363	18	MHC	MHC	NNP
cord-015910-d9gxew91	363	19	effects	effect	NNS
cord-015910-d9gxew91	363	20	on	on	IN
cord-015910-d9gxew91	363	21	longevity	longevity	NN
cord-015910-d9gxew91	363	22	in	in	IN
cord-015910-d9gxew91	363	23	humans	human	NNS
cord-015910-d9gxew91	363	24	,	,	,
cord-015910-d9gxew91	363	25	in	in	IN
cord-015910-d9gxew91	363	26	mice	mouse	NNS
cord-015910-d9gxew91	363	27	the	the	DT
cord-015910-d9gxew91	363	28	association	association	NN
cord-015910-d9gxew91	363	29	may	may	MD
cord-015910-d9gxew91	363	30	be	be	VB
cord-015910-d9gxew91	363	31	by	by	IN
cord-015910-d9gxew91	363	32	way	way	NN
cord-015910-d9gxew91	363	33	of	of	IN
cord-015910-d9gxew91	363	34	altered	alter	VBN
cord-015910-d9gxew91	363	35	susceptibility	susceptibility	NN
cord-015910-d9gxew91	363	36	to	to	IN
cord-015910-d9gxew91	363	37	lymphomas	lymphoma	NNS
cord-015910-d9gxew91	363	38	,	,	,
cord-015910-d9gxew91	363	39	whereas	whereas	IN
cord-015910-d9gxew91	363	40	in	in	IN
cord-015910-d9gxew91	363	41	human	human	JJ
cord-015910-d9gxew91	363	42	beings	being	NNS
cord-015910-d9gxew91	363	43	the	the	DT
cord-015910-d9gxew91	363	44	effect	effect	NN
cord-015910-d9gxew91	363	45	on	on	IN
cord-015910-d9gxew91	363	46	longevity	longevity	NN
cord-015910-d9gxew91	363	47	is	be	VBZ
cord-015910-d9gxew91	363	48	likely	likely	JJ
cord-015910-d9gxew91	363	49	to	to	TO
cord-015910-d9gxew91	363	50	be	be	VB
cord-015910-d9gxew91	363	51	via	via	IN
cord-015910-d9gxew91	363	52	an	an	DT
cord-015910-d9gxew91	363	53	altered	altered	JJ
cord-015910-d9gxew91	363	54	response	response	NN
cord-015910-d9gxew91	363	55	to	to	IN
cord-015910-d9gxew91	363	56	pathogens	pathogen	NNS
cord-015910-d9gxew91	363	57	and	and	CC
cord-015910-d9gxew91	363	58	susceptibility	susceptibility	NN
cord-015910-d9gxew91	363	59	to	to	IN
cord-015910-d9gxew91	363	60	infectious	infectious	JJ
cord-015910-d9gxew91	363	61	disease	disease	NN
cord-015910-d9gxew91	363	62	.	.	.
cord-015910-d9gxew91	364	1	A	a	DT
cord-015910-d9gxew91	364	2	number	number	NN
cord-015910-d9gxew91	364	3	of	of	IN
cord-015910-d9gxew91	364	4	cross	cross	JJ
cord-015910-d9gxew91	364	5	-	-	JJ
cord-015910-d9gxew91	364	6	sectional	sectional	JJ
cord-015910-d9gxew91	364	7	studies	study	NNS
cord-015910-d9gxew91	364	8	have	have	VBP
cord-015910-d9gxew91	364	9	examined	examine	VBN
cord-015910-d9gxew91	364	10	the	the	DT
cord-015910-d9gxew91	364	11	role	role	NN
cord-015910-d9gxew91	364	12	of	of	IN
cord-015910-d9gxew91	364	13	HLA	HLA	NNP
cord-015910-d9gxew91	364	14	genes	gene	NNS
cord-015910-d9gxew91	364	15	on	on	IN
cord-015910-d9gxew91	364	16	human	human	JJ
cord-015910-d9gxew91	364	17	longevity	longevity	NN
cord-015910-d9gxew91	364	18	by	by	IN
cord-015910-d9gxew91	364	19	comparing	compare	VBG
cord-015910-d9gxew91	364	20	HLA	HLA	NNP
cord-015910-d9gxew91	364	21	antigen	antigen	NN
cord-015910-d9gxew91	364	22	frequencies	frequency	NNS
cord-015910-d9gxew91	364	23	between	between	IN
cord-015910-d9gxew91	364	24	groups	group	NNS
cord-015910-d9gxew91	364	25	of	of	IN
cord-015910-d9gxew91	364	26	young	young	JJ
cord-015910-d9gxew91	364	27	and	and	CC
cord-015910-d9gxew91	364	28	elderly	elderly	JJ
cord-015910-d9gxew91	364	29	persons	person	NNS
cord-015910-d9gxew91	364	30	.	.	.
cord-015910-d9gxew91	365	1	Conflicting	conflicting	JJ
cord-015910-d9gxew91	365	2	findings	finding	NNS
cord-015910-d9gxew91	365	3	have	have	VBP
cord-015910-d9gxew91	365	4	been	be	VBN
cord-015910-d9gxew91	365	5	obtained	obtain	VBN
cord-015910-d9gxew91	365	6	.	.	.
cord-015910-d9gxew91	366	1	When	when	WRB
cord-015910-d9gxew91	366	2	this	this	DT
cord-015910-d9gxew91	366	3	topic	topic	NN
cord-015910-d9gxew91	366	4	was	be	VBD
cord-015910-d9gxew91	366	5	reviewed	review	VBN
cord-015910-d9gxew91	367	1	(	(	-LRB-
cord-015910-d9gxew91	367	2	Caruso	Caruso	NNP
cord-015910-d9gxew91	367	3	et	et	NNP
cord-015910-d9gxew91	367	4	al	al	NNP
cord-015910-d9gxew91	367	5	.	.	.
cord-015910-d9gxew91	368	1	,	,	,
cord-015910-d9gxew91	368	2	2001	2001	CD
cord-015910-d9gxew91	368	3	)	)	-RRB-
cord-015910-d9gxew91	368	4	,	,	,
cord-015910-d9gxew91	368	5	it	-PRON-	PRP
cord-015910-d9gxew91	368	6	was	be	VBD
cord-015910-d9gxew91	368	7	concluded	conclude	VBN
cord-015910-d9gxew91	368	8	that	that	IN
cord-015910-d9gxew91	368	9	in	in	IN
cord-015910-d9gxew91	368	10	humans	human	NNS
cord-015910-d9gxew91	368	11	there	there	EX
cord-015910-d9gxew91	368	12	may	may	MD
cord-015910-d9gxew91	368	13	be	be	VB
cord-015910-d9gxew91	368	14	an	an	DT
cord-015910-d9gxew91	368	15	association	association	NN
cord-015910-d9gxew91	368	16	between	between	IN
cord-015910-d9gxew91	368	17	longevity	longevity	NN
cord-015910-d9gxew91	368	18	and	and	CC
cord-015910-d9gxew91	368	19	some	some	DT
cord-015910-d9gxew91	368	20	HLA	HLA	NNP
cord-015910-d9gxew91	368	21	-	-	HYPH
cord-015910-d9gxew91	368	22	DR	DR	NNP
cord-015910-d9gxew91	368	23	alleles	allele	NNS
cord-015910-d9gxew91	368	24	or	or	CC
cord-015910-d9gxew91	368	25	the	the	DT
cord-015910-d9gxew91	368	26	HLA	HLA	NNP
cord-015910-d9gxew91	368	27	-	-	HYPH
cord-015910-d9gxew91	368	28	BS	BS	NNP
cord-015910-d9gxew91	368	29	,	,	,
cord-015910-d9gxew91	368	30	DR3	DR3	NNP
cord-015910-d9gxew91	368	31	haplotype	haplotype	NN
cord-015910-d9gxew91	368	32	.	.	.
cord-015910-d9gxew91	369	1	These	these	DT
cord-015910-d9gxew91	369	2	genotypes	genotype	NNS
cord-015910-d9gxew91	369	3	are	be	VBP
cord-015910-d9gxew91	369	4	involved	involve	VBN
cord-015910-d9gxew91	369	5	in	in	IN
cord-015910-d9gxew91	369	6	the	the	DT
cord-015910-d9gxew91	369	7	antigen	antigen	NN
cord-015910-d9gxew91	369	8	nonspecific	nonspecific	JJ
cord-015910-d9gxew91	369	9	control	control	NN
cord-015910-d9gxew91	369	10	of	of	IN
cord-015910-d9gxew91	369	11	immune	immune	JJ
cord-015910-d9gxew91	369	12	response	response	NN
cord-015910-d9gxew91	369	13	,	,	,
cord-015910-d9gxew91	369	14	in	in	IN
cord-015910-d9gxew91	369	15	other	other	JJ
cord-015910-d9gxew91	369	16	words	word	NNS
cord-015910-d9gxew91	369	17	,	,	,
cord-015910-d9gxew91	369	18	the	the	DT
cord-015910-d9gxew91	369	19	component	component	NN
cord-015910-d9gxew91	369	20	of	of	IN
cord-015910-d9gxew91	369	21	immune	immune	JJ
cord-015910-d9gxew91	369	22	function	function	NN
cord-015910-d9gxew91	369	23	associated	associate	VBN
cord-015910-d9gxew91	369	24	with	with	IN
cord-015910-d9gxew91	369	25	inflammation	inflammation	NN
cord-015910-d9gxew91	369	26	and	and	CC
cord-015910-d9gxew91	369	27	cytokine	cytokine	NN
cord-015910-d9gxew91	369	28	biology	biology	NN
cord-015910-d9gxew91	369	29	.	.	.
cord-015910-d9gxew91	370	1	Recent	recent	JJ
cord-015910-d9gxew91	370	2	evidence	evidence	NN
cord-015910-d9gxew91	370	3	indicates	indicate	VBZ
cord-015910-d9gxew91	370	4	that	that	IN
cord-015910-d9gxew91	370	5	presence	presence	NN
cord-015910-d9gxew91	370	6	of	of	IN
cord-015910-d9gxew91	370	7	SNPs	SNPs	NNPS
cord-015910-d9gxew91	370	8	in	in	IN
cord-015910-d9gxew91	370	9	certain	certain	JJ
cord-015910-d9gxew91	370	10	pro	pro	JJ
cord-015910-d9gxew91	370	11	-	-	JJ
cord-015910-d9gxew91	370	12	and	and	CC
cord-015910-d9gxew91	370	13	anti	anti	JJ
cord-015910-d9gxew91	370	14	-	-	JJ
cord-015910-d9gxew91	370	15	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	370	16	cytokine	cytokine	NN
cord-015910-d9gxew91	370	17	genes	gene	NNS
cord-015910-d9gxew91	370	18	influences	influence	VBZ
cord-015910-d9gxew91	370	19	life	life	NN
cord-015910-d9gxew91	370	20	span	span	NN
cord-015910-d9gxew91	370	21	.	.	.
cord-015910-d9gxew91	371	1	When	when	WRB
cord-015910-d9gxew91	371	2	700	700	CD
cord-015910-d9gxew91	371	3	individuals	individual	NNS
cord-015910-d9gxew91	371	4	between	between	IN
cord-015910-d9gxew91	371	5	60	60	CD
cord-015910-d9gxew91	371	6	and	and	CC
cord-015910-d9gxew91	371	7	110	110	CD
cord-015910-d9gxew91	371	8	yr	yr	NN
cord-015910-d9gxew91	371	9	of	of	IN
cord-015910-d9gxew91	371	10	age	age	NN
cord-015910-d9gxew91	371	11	were	be	VBD
cord-015910-d9gxew91	371	12	studied	study	VBN
cord-015910-d9gxew91	371	13	,	,	,
cord-015910-d9gxew91	371	14	it	-PRON-	PRP
cord-015910-d9gxew91	371	15	was	be	VBD
cord-015910-d9gxew91	371	16	noted	note	VBN
cord-015910-d9gxew91	371	17	that	that	IN
cord-015910-d9gxew91	371	18	not	not	RB
cord-015910-d9gxew91	371	19	only	only	RB
cord-015910-d9gxew91	371	20	was	be	VBD
cord-015910-d9gxew91	371	21	plasma	plasma	NN
cord-015910-d9gxew91	371	22	IL-6	IL-6	NNP
cord-015910-d9gxew91	371	23	concentration	concentration	NN
cord-015910-d9gxew91	371	24	positively	positively	RB
cord-015910-d9gxew91	371	25	related	relate	VBN
cord-015910-d9gxew91	371	26	to	to	IN
cord-015910-d9gxew91	371	27	age	age	NN
cord-015910-d9gxew91	371	28	but	but	CC
cord-015910-d9gxew91	371	29	individuals	individual	NNS
cord-015910-d9gxew91	371	30	with	with	IN
cord-015910-d9gxew91	371	31	a	a	DT
cord-015910-d9gxew91	371	32	SNP	SNP	NNP
cord-015910-d9gxew91	371	33	in	in	IN
cord-015910-d9gxew91	371	34	the	the	DT
cord-015910-d9gxew91	371	35	promoter	promoter	NN
cord-015910-d9gxew91	371	36	region	region	NN
cord-015910-d9gxew91	371	37	of	of	IN
cord-015910-d9gxew91	371	38	the	the	DT
cord-015910-d9gxew91	371	39	IL-6	IL-6	NNP
cord-015910-d9gxew91	371	40	gene	gene	NN
cord-015910-d9gxew91	371	41	,	,	,
cord-015910-d9gxew91	371	42	which	which	WDT
cord-015910-d9gxew91	371	43	predisposes	predispose	VBZ
cord-015910-d9gxew91	371	44	to	to	IN
cord-015910-d9gxew91	371	45	high	high	JJ
cord-015910-d9gxew91	371	46	levels	level	NNS
cord-015910-d9gxew91	371	47	of	of	IN
cord-015910-d9gxew91	371	48	production	production	NN
cord-015910-d9gxew91	371	49	of	of	IN
cord-015910-d9gxew91	371	50	the	the	DT
cord-015910-d9gxew91	371	51	cytokine	cytokine	NN
cord-015910-d9gxew91	371	52	(	(	-LRB-
cord-015910-d9gxew91	371	53	-174	-174	NNP
cord-015910-d9gxew91	371	54	GG	GG	NNP
cord-015910-d9gxew91	371	55	)	)	-RRB-
cord-015910-d9gxew91	371	56	,	,	,
cord-015910-d9gxew91	371	57	decreased	decrease	VBD
cord-015910-d9gxew91	371	58	in	in	IN
cord-015910-d9gxew91	371	59	frequency	frequency	NN
cord-015910-d9gxew91	371	60	with	with	IN
cord-015910-d9gxew91	371	61	age	age	NN
cord-015910-d9gxew91	371	62	.	.	.
cord-015910-d9gxew91	372	1	The	the	DT
cord-015910-d9gxew91	372	2	effect	effect	NN
cord-015910-d9gxew91	372	3	was	be	VBD
cord-015910-d9gxew91	372	4	seen	see	VBN
cord-015910-d9gxew91	372	5	in	in	IN
cord-015910-d9gxew91	372	6	men	man	NNS
cord-015910-d9gxew91	372	7	but	but	CC
cord-015910-d9gxew91	372	8	not	not	RB
cord-015910-d9gxew91	372	9	in	in	IN
cord-015910-d9gxew91	372	10	women	woman	NNS
cord-015910-d9gxew91	372	11	(	(	-LRB-
cord-015910-d9gxew91	372	12	Bonafe	Bonafe	NNP
cord-015910-d9gxew91	372	13	,	,	,
cord-015910-d9gxew91	372	14	Olivieri	Olivieri	NNP
cord-015910-d9gxew91	372	15	,	,	,
cord-015910-d9gxew91	372	16	&	&	CC
cord-015910-d9gxew91	372	17	Cavallone	Cavallone	NNP
cord-015910-d9gxew91	372	18	,	,	,
cord-015910-d9gxew91	372	19	2001	2001	CD
cord-015910-d9gxew91	372	20	)	)	-RRB-
cord-015910-d9gxew91	372	21	.	.	.
cord-015910-d9gxew91	373	1	Although	although	IN
cord-015910-d9gxew91	373	2	men	man	NNS
cord-015910-d9gxew91	373	3	with	with	IN
cord-015910-d9gxew91	373	4	SNPs	SNPs	NNPS
cord-015910-d9gxew91	373	5	made	make	VBD
cord-015910-d9gxew91	373	6	up	up	RP
cord-015910-d9gxew91	373	7	58	58	CD
cord-015910-d9gxew91	373	8	%	%	NN
cord-015910-d9gxew91	373	9	of	of	IN
cord-015910-d9gxew91	373	10	the	the	DT
cord-015910-d9gxew91	373	11	60-to	60-to	CD
cord-015910-d9gxew91	373	12	80-yr	80-yr	CD
cord-015910-d9gxew91	373	13	-	-	HYPH
cord-015910-d9gxew91	373	14	old	old	JJ
cord-015910-d9gxew91	373	15	age	age	NN
cord-015910-d9gxew91	373	16	group	group	NN
cord-015910-d9gxew91	373	17	,	,	,
cord-015910-d9gxew91	373	18	the	the	DT
cord-015910-d9gxew91	373	19	percentage	percentage	NN
cord-015910-d9gxew91	373	20	fell	fall	VBD
cord-015910-d9gxew91	373	21	to	to	IN
cord-015910-d9gxew91	373	22	38	38	CD
cord-015910-d9gxew91	373	23	%	%	NN
cord-015910-d9gxew91	373	24	in	in	IN
cord-015910-d9gxew91	373	25	subjects	subject	NNS
cord-015910-d9gxew91	373	26	<	<	XX
cord-015910-d9gxew91	373	27	99	99	CD
cord-015910-d9gxew91	373	28	years	year	NNS
cord-015910-d9gxew91	373	29	of	of	IN
cord-015910-d9gxew91	373	30	age	age	NN
cord-015910-d9gxew91	373	31	.	.	.
cord-015910-d9gxew91	374	1	Conversely	conversely	RB
cord-015910-d9gxew91	374	2	,	,	,
cord-015910-d9gxew91	374	3	one	one	CD
cord-015910-d9gxew91	374	4	of	of	IN
cord-015910-d9gxew91	374	5	three	three	CD
cord-015910-d9gxew91	374	6	SNPs	SNPs	NNPS
cord-015910-d9gxew91	374	7	in	in	IN
cord-015910-d9gxew91	374	8	the	the	DT
cord-015910-d9gxew91	374	9	IL-10	IL-10	NNP
cord-015910-d9gxew91	374	10	gene	gene	NN
cord-015910-d9gxew91	374	11	(	(	-LRB-
cord-015910-d9gxew91	374	12	-1082	-1082	:
cord-015910-d9gxew91	374	13	GG	GG	NNP
cord-015910-d9gxew91	374	14	)	)	-RRB-
cord-015910-d9gxew91	374	15	,	,	,
cord-015910-d9gxew91	374	16	which	which	WDT
cord-015910-d9gxew91	374	17	is	be	VBZ
cord-015910-d9gxew91	374	18	closely	closely	RB
cord-015910-d9gxew91	374	19	linked	link	VBN
cord-015910-d9gxew91	374	20	to	to	IN
cord-015910-d9gxew91	374	21	higher	high	JJR
cord-015910-d9gxew91	374	22	production	production	NN
cord-015910-d9gxew91	374	23	of	of	IN
cord-015910-d9gxew91	374	24	the	the	DT
cord-015910-d9gxew91	374	25	anti	anti	JJ
cord-015910-d9gxew91	374	26	-	-	JJ
cord-015910-d9gxew91	374	27	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	374	28	cytokine	cytokine	NN
cord-015910-d9gxew91	374	29	IL-10	IL-10	NNP
cord-015910-d9gxew91	374	30	(	(	-LRB-
cord-015910-d9gxew91	374	31	Hutchinson	Hutchinson	NNP
cord-015910-d9gxew91	374	32	,	,	,
cord-015910-d9gxew91	374	33	Pravica	Pravica	NNP
cord-015910-d9gxew91	374	34	,	,	,
cord-015910-d9gxew91	374	35	Hajeer	Hajeer	NNP
cord-015910-d9gxew91	374	36	,	,	,
cord-015910-d9gxew91	374	37	&	&	CC
cord-015910-d9gxew91	374	38	Sinnott	Sinnott	NNP
cord-015910-d9gxew91	374	39	,	,	,
cord-015910-d9gxew91	374	40	1999	1999	CD
cord-015910-d9gxew91	374	41	;	;	:
cord-015910-d9gxew91	374	42	Turner	Turner	NNP
cord-015910-d9gxew91	374	43	et	et	NNP
cord-015910-d9gxew91	374	44	al	al	NNP
cord-015910-d9gxew91	374	45	.	.	NNP
cord-015910-d9gxew91	374	46	,	,	,
cord-015910-d9gxew91	374	47	1997	1997	CD
cord-015910-d9gxew91	374	48	)	)	-RRB-
cord-015910-d9gxew91	374	49	,	,	,
cord-015910-d9gxew91	374	50	was	be	VBD
cord-015910-d9gxew91	374	51	found	find	VBN
cord-015910-d9gxew91	374	52	in	in	IN
cord-015910-d9gxew91	374	53	higher	high	JJR
cord-015910-d9gxew91	374	54	proportions	proportion	NNS
cord-015910-d9gxew91	374	55	in	in	IN
cord-015910-d9gxew91	374	56	male	male	JJ
cord-015910-d9gxew91	374	57	centenarians	centenarian	NNS
cord-015910-d9gxew91	374	58	than	than	IN
cord-015910-d9gxew91	374	59	in	in	IN
cord-015910-d9gxew91	374	60	younger	young	JJR
cord-015910-d9gxew91	374	61	controls	control	NNS
cord-015910-d9gxew91	374	62	(	(	-LRB-
cord-015910-d9gxew91	374	63	58	58	CD
cord-015910-d9gxew91	374	64	vs	vs	IN
cord-015910-d9gxew91	374	65	34	34	CD
cord-015910-d9gxew91	374	66	%	%	NN
cord-015910-d9gxew91	374	67	)	)	-RRB-
cord-015910-d9gxew91	374	68	.	.	.
cord-015910-d9gxew91	375	1	In	in	IN
cord-015910-d9gxew91	375	2	females	female	NNS
cord-015910-d9gxew91	375	3	this	this	DT
cord-015910-d9gxew91	375	4	genotype	genotype	NN
cord-015910-d9gxew91	375	5	exerted	exert	VBD
cord-015910-d9gxew91	375	6	no	no	DT
cord-015910-d9gxew91	375	7	effect	effect	NN
cord-015910-d9gxew91	375	8	upon	upon	IN
cord-015910-d9gxew91	375	9	longevity	longevity	NN
cord-015910-d9gxew91	376	1	(	(	-LRB-
cord-015910-d9gxew91	376	2	Lio	Lio	NNP
cord-015910-d9gxew91	376	3	et	et	NNP
cord-015910-d9gxew91	376	4	al	al	NNP
cord-015910-d9gxew91	376	5	.	.	NNP
cord-015910-d9gxew91	376	6	,	,	,
cord-015910-d9gxew91	376	7	2002	2002	CD
cord-015910-d9gxew91	376	8	)	)	-RRB-
cord-015910-d9gxew91	376	9	.	.	.
cord-015910-d9gxew91	377	1	Thus	thus	RB
cord-015910-d9gxew91	377	2	,	,	,
cord-015910-d9gxew91	377	3	it	-PRON-	PRP
cord-015910-d9gxew91	377	4	would	would	MD
cord-015910-d9gxew91	377	5	appear	appear	VB
cord-015910-d9gxew91	377	6	that	that	IN
cord-015910-d9gxew91	377	7	genetic	genetic	JJ
cord-015910-d9gxew91	377	8	characteristics	characteristic	NNS
cord-015910-d9gxew91	377	9	that	that	WDT
cord-015910-d9gxew91	377	10	might	may	MD
cord-015910-d9gxew91	377	11	influence	influence	VB
cord-015910-d9gxew91	377	12	the	the	DT
cord-015910-d9gxew91	377	13	balance	balance	NN
cord-015910-d9gxew91	377	14	between	between	IN
cord-015910-d9gxew91	377	15	proand	proand	JJ
cord-015910-d9gxew91	377	16	anti	anti	JJ
cord-015910-d9gxew91	377	17	-	-	JJ
cord-015910-d9gxew91	377	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	377	19	cytokines	cytokine	NNS
cord-015910-d9gxew91	377	20	influence	influence	VBP
cord-015910-d9gxew91	377	21	mortality	mortality	NN
cord-015910-d9gxew91	377	22	in	in	IN
cord-015910-d9gxew91	377	23	men	man	NNS
cord-015910-d9gxew91	377	24	but	but	CC
cord-015910-d9gxew91	377	25	not	not	RB
cord-015910-d9gxew91	377	26	in	in	IN
cord-015910-d9gxew91	377	27	women	woman	NNS
cord-015910-d9gxew91	377	28	(	(	-LRB-
cord-015910-d9gxew91	377	29	Franceschi	Franceschi	NNP
cord-015910-d9gxew91	377	30	et	et	NNP
cord-015910-d9gxew91	377	31	al	al	NNP
cord-015910-d9gxew91	377	32	.	.	NNP
cord-015910-d9gxew91	377	33	,	,	,
cord-015910-d9gxew91	377	34	2000	2000	CD
cord-015910-d9gxew91	377	35	)	)	-RRB-
cord-015910-d9gxew91	377	36	.	.	.
cord-015910-d9gxew91	378	1	A	a	DT
cord-015910-d9gxew91	378	2	study	study	NN
cord-015910-d9gxew91	378	3	on	on	IN
cord-015910-d9gxew91	378	4	SNPs	snp	NNS
cord-015910-d9gxew91	378	5	that	that	WDT
cord-015910-d9gxew91	378	6	influence	influence	VBP
cord-015910-d9gxew91	378	7	interferon	interferon	NN
cord-015910-d9gxew91	379	1	(	(	-LRB-
cord-015910-d9gxew91	379	2	IFN)-~t	ifn)-~t	JJ
cord-015910-d9gxew91	379	3	production	production	NN
cord-015910-d9gxew91	379	4	further	further	RB
cord-015910-d9gxew91	379	5	reinforces	reinforce	VBZ
cord-015910-d9gxew91	379	6	the	the	DT
cord-015910-d9gxew91	379	7	concept	concept	NN
cord-015910-d9gxew91	379	8	that	that	IN
cord-015910-d9gxew91	379	9	possession	possession	NN
cord-015910-d9gxew91	379	10	of	of	IN
cord-015910-d9gxew91	379	11	a	a	DT
cord-015910-d9gxew91	379	12	genotype	genotype	NN
cord-015910-d9gxew91	379	13	that	that	WDT
cord-015910-d9gxew91	379	14	predisposes	predispose	VBZ
cord-015910-d9gxew91	379	15	to	to	IN
cord-015910-d9gxew91	379	16	a	a	DT
cord-015910-d9gxew91	379	17	raised	raise	VBN
cord-015910-d9gxew91	379	18	pro	pro	JJ
cord-015910-d9gxew91	379	19	-	-	JJ
cord-015910-d9gxew91	379	20	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	379	21	status	status	NN
cord-015910-d9gxew91	379	22	is	be	VBZ
cord-015910-d9gxew91	379	23	not	not	RB
cord-015910-d9gxew91	379	24	compatible	compatible	JJ
cord-015910-d9gxew91	379	25	with	with	IN
cord-015910-d9gxew91	379	26	a	a	DT
cord-015910-d9gxew91	379	27	long	long	JJ
cord-015910-d9gxew91	379	28	life	life	NN
cord-015910-d9gxew91	379	29	span	span	NN
cord-015910-d9gxew91	379	30	(	(	-LRB-
cord-015910-d9gxew91	379	31	Lio	Lio	NNP
cord-015910-d9gxew91	379	32	et	et	NNP
cord-015910-d9gxew91	379	33	al	al	NNP
cord-015910-d9gxew91	379	34	.	.	NNP
cord-015910-d9gxew91	379	35	,	,	,
cord-015910-d9gxew91	379	36	2002	2002	CD
cord-015910-d9gxew91	379	37	)	)	-RRB-
cord-015910-d9gxew91	379	38	.	.	.
cord-015910-d9gxew91	380	1	In	in	IN
cord-015910-d9gxew91	380	2	women	woman	NNS
cord-015910-d9gxew91	380	3	,	,	,
cord-015910-d9gxew91	380	4	possession	possession	NN
cord-015910-d9gxew91	380	5	of	of	IN
cord-015910-d9gxew91	380	6	the	the	DT
cord-015910-d9gxew91	380	7	A	a	DT
cord-015910-d9gxew91	380	8	allele	allele	NN
cord-015910-d9gxew91	380	9	,	,	,
cord-015910-d9gxew91	380	10	which	which	WDT
cord-015910-d9gxew91	380	11	is	be	VBZ
cord-015910-d9gxew91	380	12	associated	associate	VBN
cord-015910-d9gxew91	380	13	with	with	IN
cord-015910-d9gxew91	380	14	low	low	JJ
cord-015910-d9gxew91	380	15	production	production	NN
cord-015910-d9gxew91	380	16	of	of	IN
cord-015910-d9gxew91	380	17	IFN-'~	IFN-'~	NNP
cord-015910-d9gxew91	380	18	,	,	,
cord-015910-d9gxew91	380	19	significantly	significantly	RB
cord-015910-d9gxew91	380	20	increased	increase	VBD
cord-015910-d9gxew91	380	21	the	the	DT
cord-015910-d9gxew91	380	22	possibility	possibility	NN
cord-015910-d9gxew91	380	23	of	of	IN
cord-015910-d9gxew91	380	24	reaching	reach	VBG
cord-015910-d9gxew91	380	25	old	old	JJ
cord-015910-d9gxew91	380	26	age	age	NN
cord-015910-d9gxew91	380	27	.	.	.
cord-015910-d9gxew91	381	1	It	-PRON-	PRP
cord-015910-d9gxew91	381	2	might	may	MD
cord-015910-d9gxew91	381	3	be	be	VB
cord-015910-d9gxew91	381	4	concluded	conclude	VBN
cord-015910-d9gxew91	381	5	that	that	IN
cord-015910-d9gxew91	381	6	possession	possession	NN
cord-015910-d9gxew91	381	7	of	of	IN
cord-015910-d9gxew91	381	8	high	high	RB
cord-015910-d9gxew91	381	9	-	-	HYPH
cord-015910-d9gxew91	381	10	producing	produce	VBG
cord-015910-d9gxew91	381	11	alleles	allele	NNS
cord-015910-d9gxew91	381	12	of	of	IN
cord-015910-d9gxew91	381	13	the	the	DT
cord-015910-d9gxew91	381	14	IL-10	IL-10	NNP
cord-015910-d9gxew91	381	15	is	be	VBZ
cord-015910-d9gxew91	381	16	universally	universally	RB
cord-015910-d9gxew91	381	17	protective	protective	JJ
cord-015910-d9gxew91	381	18	against	against	IN
cord-015910-d9gxew91	381	19	morbidity	morbidity	NN
cord-015910-d9gxew91	381	20	as	as	RB
cord-015910-d9gxew91	381	21	well	well	RB
cord-015910-d9gxew91	381	22	as	as	IN
cord-015910-d9gxew91	381	23	mortality	mortality	NN
cord-015910-d9gxew91	381	24	.	.	.
cord-015910-d9gxew91	382	1	Possession	possession	NN
cord-015910-d9gxew91	382	2	of	of	IN
cord-015910-d9gxew91	382	3	a	a	DT
cord-015910-d9gxew91	382	4	genotype	genotype	NN
cord-015910-d9gxew91	382	5	that	that	WDT
cord-015910-d9gxew91	382	6	results	result	VBZ
cord-015910-d9gxew91	382	7	in	in	IN
cord-015910-d9gxew91	382	8	low	low	JJ
cord-015910-d9gxew91	382	9	levels	level	NNS
cord-015910-d9gxew91	382	10	of	of	IN
cord-015910-d9gxew91	382	11	IL-10	IL-10	NNP
cord-015910-d9gxew91	382	12	production	production	NN
cord-015910-d9gxew91	382	13	(	(	-LRB-
cord-015910-d9gxew91	382	14	-1082	-1082	``
cord-015910-d9gxew91	382	15	AA	AA	NNP
cord-015910-d9gxew91	382	16	)	)	-RRB-
cord-015910-d9gxew91	382	17	increases	increase	VBZ
cord-015910-d9gxew91	382	18	the	the	DT
cord-015910-d9gxew91	382	19	risk	risk	NN
cord-015910-d9gxew91	382	20	of	of	IN
cord-015910-d9gxew91	382	21	developing	develop	VBG
cord-015910-d9gxew91	382	22	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	382	23	diseases	disease	NNS
cord-015910-d9gxew91	382	24	(	(	-LRB-
cord-015910-d9gxew91	382	25	Hajeer	Hajeer	NNP
cord-015910-d9gxew91	382	26	,	,	,
cord-015910-d9gxew91	382	27	Lazanes	Lazanes	NNP
cord-015910-d9gxew91	382	28	,	,	,
cord-015910-d9gxew91	382	29	&	&	CC
cord-015910-d9gxew91	382	30	Turner	Turner	NNP
cord-015910-d9gxew91	382	31	,	,	,
cord-015910-d9gxew91	382	32	1998	1998	CD
cord-015910-d9gxew91	382	33	;	;	:
cord-015910-d9gxew91	382	34	Huizinga	Huizinga	NNP
cord-015910-d9gxew91	382	35	,	,	,
cord-015910-d9gxew91	382	36	Keijsers	Keijsers	NNP
cord-015910-d9gxew91	382	37	,	,	,
cord-015910-d9gxew91	382	38	&	&	CC
cord-015910-d9gxew91	382	39	Yanni	Yanni	NNP
cord-015910-d9gxew91	382	40	,	,	,
cord-015910-d9gxew91	382	41	2002	2002	CD
cord-015910-d9gxew91	382	42	;	;	:
cord-015910-d9gxew91	382	43	Tagore	Tagore	NNP
cord-015910-d9gxew91	382	44	,	,	,
cord-015910-d9gxew91	382	45	Gonsalkorale	Gonsalkorale	NNP
cord-015910-d9gxew91	382	46	,	,	,
cord-015910-d9gxew91	382	47	&	&	CC
cord-015910-d9gxew91	382	48	Pravica	Pravica	NNP
cord-015910-d9gxew91	382	49	,	,	,
cord-015910-d9gxew91	382	50	1999	1999	CD
cord-015910-d9gxew91	382	51	)	)	-RRB-
cord-015910-d9gxew91	382	52	.	.	.
cord-015910-d9gxew91	383	1	However	however	RB
cord-015910-d9gxew91	383	2	,	,	,
cord-015910-d9gxew91	383	3	as	as	IN
cord-015910-d9gxew91	383	4	already	already	RB
cord-015910-d9gxew91	383	5	mentioned	mention	VBN
cord-015910-d9gxew91	383	6	,	,	,
cord-015910-d9gxew91	383	7	in	in	IN
cord-015910-d9gxew91	383	8	a	a	DT
cord-015910-d9gxew91	383	9	large	large	JJ
cord-015910-d9gxew91	383	10	survey	survey	NN
cord-015910-d9gxew91	383	11	of	of	IN
cord-015910-d9gxew91	383	12	hospitai	hospitai	NNP
cord-015910-d9gxew91	383	13	admission	admission	NN
cord-015910-d9gxew91	383	14	in	in	IN
cord-015910-d9gxew91	383	15	the	the	DT
cord-015910-d9gxew91	383	16	Netherlands	Netherlands	NNP
cord-015910-d9gxew91	383	17	,	,	,
cord-015910-d9gxew91	383	18	patients	patient	NNS
cord-015910-d9gxew91	383	19	with	with	IN
cord-015910-d9gxew91	383	20	raised	raise	VBN
cord-015910-d9gxew91	383	21	IL-10	IL-10	NNP
cord-015910-d9gxew91	383	22	:	:	:
cord-015910-d9gxew91	383	23	IL-6	IL-6	NNP
cord-015910-d9gxew91	383	24	ratios	ratio	NNS
cord-015910-d9gxew91	383	25	had	have	VBD
cord-015910-d9gxew91	383	26	higher	high	JJR
cord-015910-d9gxew91	383	27	mortality	mortality	NN
cord-015910-d9gxew91	383	28	rates	rate	NNS
cord-015910-d9gxew91	383	29	(	(	-LRB-
cord-015910-d9gxew91	383	30	Van	Van	NNP
cord-015910-d9gxew91	383	31	Dissel	Dissel	NNP
cord-015910-d9gxew91	383	32	et	et	FW
cord-015910-d9gxew91	383	33	al	al	NNP
cord-015910-d9gxew91	383	34	.	.	NNP
cord-015910-d9gxew91	383	35	,	,	,
cord-015910-d9gxew91	383	36	1998	1998	CD
cord-015910-d9gxew91	383	37	)	)	-RRB-
cord-015910-d9gxew91	383	38	.	.	.
cord-015910-d9gxew91	384	1	Not	not	RB
cord-015910-d9gxew91	384	2	all	all	DT
cord-015910-d9gxew91	384	3	studies	study	NNS
cord-015910-d9gxew91	384	4	implicate	implicate	VBP
cord-015910-d9gxew91	384	5	cytokine	cytokine	NN
cord-015910-d9gxew91	384	6	gene	gene	NN
cord-015910-d9gxew91	384	7	SNP	SNP	NNP
cord-015910-d9gxew91	384	8	in	in	IN
cord-015910-d9gxew91	384	9	longevity	longevity	NN
cord-015910-d9gxew91	384	10	.	.	.
cord-015910-d9gxew91	385	1	Cytokine	cytokine	NN
cord-015910-d9gxew91	385	2	gene	gene	NN
cord-015910-d9gxew91	385	3	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	385	4	at	at	IN
cord-015910-d9gxew91	385	5	IL-1	IL-1	NNP
cord-015910-d9gxew91	385	6	o~	o~	NNP
cord-015910-d9gxew91	385	7	,	,	,
cord-015910-d9gxew91	386	1	IL-1	IL-1	NNP
cord-015910-d9gxew91	386	2	~	~	NFP
cord-015910-d9gxew91	386	3	,	,	,
cord-015910-d9gxew91	386	4	IL-1RA	IL-1RA	NNP
cord-015910-d9gxew91	386	5	,	,	,
cord-015910-d9gxew91	386	6	IL-6	IL-6	NNP
cord-015910-d9gxew91	386	7	,	,	,
cord-015910-d9gxew91	386	8	IL-10	IL-10	NNP
cord-015910-d9gxew91	386	9	,	,	,
cord-015910-d9gxew91	386	10	and	and	CC
cord-015910-d9gxew91	386	11	TNF	TNF	NNP
cord-015910-d9gxew91	386	12	-	-	HYPH
cord-015910-d9gxew91	386	13	o~	o~	NNP
cord-015910-d9gxew91	386	14	were	be	VBD
cord-015910-d9gxew91	386	15	measured	measure	VBN
cord-015910-d9gxew91	386	16	in	in	IN
cord-015910-d9gxew91	386	17	250	250	CD
cord-015910-d9gxew91	386	18	Finnish	finnish	JJ
cord-015910-d9gxew91	386	19	nonagenarians	nonagenarian	NNS
cord-015910-d9gxew91	386	20	(	(	-LRB-
cord-015910-d9gxew91	386	21	52	52	CD
cord-015910-d9gxew91	386	22	men	man	NNS
cord-015910-d9gxew91	386	23	and	and	CC
cord-015910-d9gxew91	386	24	198	198	CD
cord-015910-d9gxew91	386	25	women	woman	NNS
cord-015910-d9gxew91	386	26	)	)	-RRB-
cord-015910-d9gxew91	386	27	and	and	CC
cord-015910-d9gxew91	386	28	in	in	IN
cord-015910-d9gxew91	386	29	400	400	CD
cord-015910-d9gxew91	386	30	healthy	healthy	JJ
cord-015910-d9gxew91	386	31	blood	blood	NN
cord-015910-d9gxew91	386	32	donors	donor	NNS
cord-015910-d9gxew91	386	33	(	(	-LRB-
cord-015910-d9gxew91	386	34	18	18	CD
cord-015910-d9gxew91	386	35	-	-	SYM
cord-015910-d9gxew91	386	36	60	60	CD
cord-015910-d9gxew91	386	37	yr	yr	NN
cord-015910-d9gxew91	386	38	)	)	-RRB-
cord-015910-d9gxew91	386	39	used	use	VBD
cord-015910-d9gxew91	386	40	as	as	IN
cord-015910-d9gxew91	386	41	controls	control	NNS
cord-015910-d9gxew91	386	42	.	.	.
cord-015910-d9gxew91	387	1	No	no	DT
cord-015910-d9gxew91	387	2	statistically	statistically	RB
cord-015910-d9gxew91	387	3	significant	significant	JJ
cord-015910-d9gxew91	387	4	differences	difference	NNS
cord-015910-d9gxew91	387	5	were	be	VBD
cord-015910-d9gxew91	387	6	found	find	VBN
cord-015910-d9gxew91	387	7	in	in	IN
cord-015910-d9gxew91	387	8	the	the	DT
cord-015910-d9gxew91	387	9	distribution	distribution	NN
cord-015910-d9gxew91	387	10	of	of	IN
cord-015910-d9gxew91	387	11	genotype	genotype	NN
cord-015910-d9gxew91	387	12	,	,	,
cord-015910-d9gxew91	387	13	allelic	allelic	JJ
cord-015910-d9gxew91	387	14	frequencies	frequency	NNS
cord-015910-d9gxew91	387	15	,	,	,
cord-015910-d9gxew91	387	16	and	and	CC
cord-015910-d9gxew91	387	17	A2	a2	NN
cord-015910-d9gxew91	387	18	+	+	CC
cord-015910-d9gxew91	387	19	carrier	carrier	NN
cord-015910-d9gxew91	387	20	status	status	NN
cord-015910-d9gxew91	387	21	between	between	IN
cord-015910-d9gxew91	387	22	nonagenarians	nonagenarian	NNS
cord-015910-d9gxew91	387	23	and	and	CC
cord-015910-d9gxew91	387	24	younger	young	JJR
cord-015910-d9gxew91	387	25	controls	control	NNS
cord-015910-d9gxew91	387	26	(	(	-LRB-
cord-015910-d9gxew91	387	27	Wang	Wang	NNP
cord-015910-d9gxew91	387	28	,	,	,
cord-015910-d9gxew91	387	29	Hurme	Hurme	NNP
cord-015910-d9gxew91	387	30	,	,	,
cord-015910-d9gxew91	387	31	Jylha	Jylha	NNP
cord-015910-d9gxew91	387	32	,	,	,
cord-015910-d9gxew91	387	33	&	&	CC
cord-015910-d9gxew91	387	34	Hervonen	Hervonen	NNP
cord-015910-d9gxew91	387	35	,	,	,
cord-015910-d9gxew91	387	36	2001	2001	CD
cord-015910-d9gxew91	387	37	)	)	-RRB-
cord-015910-d9gxew91	387	38	.	.	.
cord-015910-d9gxew91	388	1	In	in	IN
cord-015910-d9gxew91	388	2	a	a	DT
cord-015910-d9gxew91	388	3	review	review	NN
cord-015910-d9gxew91	388	4	on	on	IN
cord-015910-d9gxew91	388	5	the	the	DT
cord-015910-d9gxew91	388	6	different	different	JJ
cord-015910-d9gxew91	388	7	impact	impact	NN
cord-015910-d9gxew91	388	8	of	of	IN
cord-015910-d9gxew91	388	9	genetic	genetic	JJ
cord-015910-d9gxew91	388	10	factors	factor	NNS
cord-015910-d9gxew91	388	11	on	on	IN
cord-015910-d9gxew91	388	12	the	the	DT
cord-015910-d9gxew91	388	13	probability	probability	NN
cord-015910-d9gxew91	388	14	of	of	IN
cord-015910-d9gxew91	388	15	reaching	reach	VBG
cord-015910-d9gxew91	388	16	old	old	JJ
cord-015910-d9gxew91	388	17	age	age	NN
cord-015910-d9gxew91	388	18	,	,	,
cord-015910-d9gxew91	388	19	Franceschi	Franceschi	NNP
cord-015910-d9gxew91	388	20	et	et	NNP
cord-015910-d9gxew91	388	21	al	al	NNP
cord-015910-d9gxew91	388	22	.	.	.
cord-015910-d9gxew91	389	1	(	(	-LRB-
cord-015910-d9gxew91	389	2	2000	2000	CD
cord-015910-d9gxew91	389	3	)	)	-RRB-
cord-015910-d9gxew91	389	4	concluded	conclude	VBD
cord-015910-d9gxew91	389	5	from	from	IN
cord-015910-d9gxew91	389	6	studies	study	NNS
cord-015910-d9gxew91	389	7	conducted	conduct	VBN
cord-015910-d9gxew91	389	8	in	in	IN
cord-015910-d9gxew91	389	9	Italy	Italy	NNP
cord-015910-d9gxew91	389	10	that	that	IN
cord-015910-d9gxew91	389	11	emerging	emerge	VBG
cord-015910-d9gxew91	389	12	evidence	evidence	NN
cord-015910-d9gxew91	389	13	(	(	-LRB-
cord-015910-d9gxew91	389	14	regarding	regard	VBG
cord-015910-d9gxew91	389	15	mtDNA	mtdna	NN
cord-015910-d9gxew91	389	16	haplogroups	haplogroup	NNS
cord-015910-d9gxew91	389	17	,	,	,
cord-015910-d9gxew91	389	18	thyrosine	thyrosine	JJ
cord-015910-d9gxew91	389	19	hydroxylase	hydroxylase	NN
cord-015910-d9gxew91	389	20	,	,	,
cord-015910-d9gxew91	389	21	and	and	CC
cord-015910-d9gxew91	389	22	IL-6	IL-6	NNP
cord-015910-d9gxew91	389	23	genes	gene	NNS
cord-015910-d9gxew91	389	24	)	)	-RRB-
cord-015910-d9gxew91	389	25	suggests	suggest	VBZ
cord-015910-d9gxew91	389	26	that	that	IN
cord-015910-d9gxew91	389	27	female	female	JJ
cord-015910-d9gxew91	389	28	longevity	longevity	NN
cord-015910-d9gxew91	389	29	is	be	VBZ
cord-015910-d9gxew91	389	30	less	less	RBR
cord-015910-d9gxew91	389	31	dependent	dependent	JJ
cord-015910-d9gxew91	389	32	on	on	IN
cord-015910-d9gxew91	389	33	genetics	genetic	NNS
cord-015910-d9gxew91	389	34	than	than	IN
cord-015910-d9gxew91	389	35	male	male	JJ
cord-015910-d9gxew91	389	36	longevity	longevity	NN
cord-015910-d9gxew91	389	37	and	and	CC
cord-015910-d9gxew91	389	38	that	that	IN
cord-015910-d9gxew91	389	39	female	female	JJ
cord-015910-d9gxew91	389	40	centenarians	centenarian	NNS
cord-015910-d9gxew91	389	41	are	be	VBP
cord-015910-d9gxew91	389	42	more	more	RBR
cord-015910-d9gxew91	389	43	likely	likely	JJ
cord-015910-d9gxew91	389	44	to	to	TO
cord-015910-d9gxew91	389	45	have	have	VB
cord-015910-d9gxew91	389	46	had	have	VBN
cord-015910-d9gxew91	389	47	a	a	DT
cord-015910-d9gxew91	389	48	healthier	healthy	JJR
cord-015910-d9gxew91	389	49	lifestyle	lifestyle	NN
cord-015910-d9gxew91	389	50	and	and	CC
cord-015910-d9gxew91	389	51	more	more	RBR
cord-015910-d9gxew91	389	52	favorable	favorable	JJ
cord-015910-d9gxew91	389	53	environmental	environmental	JJ
cord-015910-d9gxew91	389	54	conditions	condition	NNS
cord-015910-d9gxew91	389	55	than	than	IN
cord-015910-d9gxew91	389	56	males	male	NNS
cord-015910-d9gxew91	389	57	.	.	.
cord-015910-d9gxew91	390	1	However	however	RB
cord-015910-d9gxew91	390	2	,	,	,
cord-015910-d9gxew91	390	3	a	a	DT
cord-015910-d9gxew91	390	4	recent	recent	JJ
cord-015910-d9gxew91	390	5	study	study	NN
cord-015910-d9gxew91	390	6	conducted	conduct	VBN
cord-015910-d9gxew91	390	7	by	by	IN
cord-015910-d9gxew91	390	8	our	-PRON-	PRP$
cord-015910-d9gxew91	390	9	group	group	NN
cord-015910-d9gxew91	390	10	suggests	suggest	VBZ
cord-015910-d9gxew91	390	11	that	that	IN
cord-015910-d9gxew91	390	12	although	although	IN
cord-015910-d9gxew91	390	13	a	a	DT
cord-015910-d9gxew91	390	14	pro	pro	JJ
cord-015910-d9gxew91	390	15	-	-	JJ
cord-015910-d9gxew91	390	16	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	390	17	genotype	genotype	NN
cord-015910-d9gxew91	390	18	may	may	MD
cord-015910-d9gxew91	390	19	be	be	VB
cord-015910-d9gxew91	390	20	disadvantageous	disadvantageous	JJ
cord-015910-d9gxew91	390	21	to	to	IN
cord-015910-d9gxew91	390	22	elderly	elderly	JJ
cord-015910-d9gxew91	390	23	males	male	NNS
cord-015910-d9gxew91	390	24	,	,	,
cord-015910-d9gxew91	390	25	it	-PRON-	PRP
cord-015910-d9gxew91	390	26	may	may	MD
cord-015910-d9gxew91	390	27	confer	confer	VB
cord-015910-d9gxew91	390	28	a	a	DT
cord-015910-d9gxew91	390	29	survival	survival	NN
cord-015910-d9gxew91	390	30	benefit	benefit	NN
cord-015910-d9gxew91	390	31	in	in	IN
cord-015910-d9gxew91	390	32	females	female	NNS
cord-015910-d9gxew91	390	33	.	.	.
cord-015910-d9gxew91	391	1	Subsequent	subsequent	JJ
cord-015910-d9gxew91	391	2	survival	survival	NN
cord-015910-d9gxew91	391	3	was	be	VBD
cord-015910-d9gxew91	391	4	studied	study	VBN
cord-015910-d9gxew91	391	5	in	in	IN
cord-015910-d9gxew91	391	6	79	79	CD
cord-015910-d9gxew91	391	7	elderly	elderly	JJ
cord-015910-d9gxew91	391	8	geriatric	geriatric	JJ
cord-015910-d9gxew91	391	9	patients	patient	NNS
cord-015910-d9gxew91	391	10	(	(	-LRB-
cord-015910-d9gxew91	391	11	87	87	CD
cord-015910-d9gxew91	391	12	+	+	SYM
cord-015910-d9gxew91	391	13	7	7	CD
cord-015910-d9gxew91	391	14	yr	yr	NN
cord-015910-d9gxew91	391	15	)	)	-RRB-
cord-015910-d9gxew91	391	16	after	after	IN
cord-015910-d9gxew91	391	17	a	a	DT
cord-015910-d9gxew91	391	18	period	period	NN
cord-015910-d9gxew91	391	19	of	of	IN
cord-015910-d9gxew91	391	20	hospitalization	hospitalization	NN
cord-015910-d9gxew91	391	21	for	for	IN
cord-015910-d9gxew91	391	22	a	a	DT
cord-015910-d9gxew91	391	23	range	range	NN
cord-015910-d9gxew91	391	24	of	of	IN
cord-015910-d9gxew91	391	25	conditions	condition	NNS
cord-015910-d9gxew91	391	26	necessitating	necessitate	VBG
cord-015910-d9gxew91	391	27	geriatric	geriatric	JJ
cord-015910-d9gxew91	391	28	care	care	NN
cord-015910-d9gxew91	391	29	.	.	.
cord-015910-d9gxew91	392	1	Although	although	IN
cord-015910-d9gxew91	392	2	women	woman	NNS
cord-015910-d9gxew91	392	3	possessing	possess	VBG
cord-015910-d9gxew91	392	4	a	a	DT
cord-015910-d9gxew91	392	5	pro	pro	JJ
cord-015910-d9gxew91	392	6	-	-	JJ
cord-015910-d9gxew91	392	7	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	392	8	genotype	genotype	NN
cord-015910-d9gxew91	392	9	(	(	-LRB-
cord-015910-d9gxew91	392	10	TNF	TNF	NNP
cord-015910-d9gxew91	392	11	-	-	HYPH
cord-015910-d9gxew91	392	12	o~-308	o~-308	NNP
cord-015910-d9gxew91	392	13	A	a	DT
cord-015910-d9gxew91	392	14	allele	allele	NN
cord-015910-d9gxew91	392	15	or	or	CC
cord-015910-d9gxew91	392	16	IL-6	IL-6	NNP
cord-015910-d9gxew91	392	17	-	-	HYPH
cord-015910-d9gxew91	392	18	174	174	CD
cord-015910-d9gxew91	392	19	GG	GG	NNP
cord-015910-d9gxew91	392	20	)	)	-RRB-
cord-015910-d9gxew91	392	21	had	have	VBD
cord-015910-d9gxew91	392	22	improved	improve	VBN
cord-015910-d9gxew91	392	23	3	3	CD
cord-015910-d9gxew91	392	24	yr	yr	NN
cord-015910-d9gxew91	392	25	survival	survival	NN
cord-015910-d9gxew91	392	26	rates	rate	NNS
cord-015910-d9gxew91	392	27	,	,	,
cord-015910-d9gxew91	392	28	men	man	NNS
cord-015910-d9gxew91	392	29	possessing	possess	VBG
cord-015910-d9gxew91	392	30	pro	pro	JJ
cord-015910-d9gxew91	392	31	-	-	JJ
cord-015910-d9gxew91	392	32	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	392	33	genotypes	genotype	NNS
cord-015910-d9gxew91	392	34	(	(	-LRB-
cord-015910-d9gxew91	392	35	IL	IL	NNP
cord-015910-d9gxew91	392	36	-	-	HYPH
cord-015910-d9gxew91	392	37	l~-511	l~-511	NNP
cord-015910-d9gxew91	392	38	T	T	NNP
cord-015910-d9gxew91	392	39	allele	allele	NN
cord-015910-d9gxew91	392	40	or	or	CC
cord-015910-d9gxew91	392	41	LT	LT	NNP
cord-015910-d9gxew91	392	42	-	-	HYPH
cord-015910-d9gxew91	392	43	ct	ct	NNP
cord-015910-d9gxew91	392	44	+252	+252	NNP
cord-015910-d9gxew91	392	45	AA	AA	NNP
cord-015910-d9gxew91	392	46	)	)	-RRB-
cord-015910-d9gxew91	392	47	had	have	VBD
cord-015910-d9gxew91	392	48	shortened	shorten	VBN
cord-015910-d9gxew91	392	49	survival	survival	NN
cord-015910-d9gxew91	392	50	rates	rate	NNS
cord-015910-d9gxew91	392	51	(	(	-LRB-
cord-015910-d9gxew91	392	52	Grimble	Grimble	NNP
cord-015910-d9gxew91	392	53	,	,	,
cord-015910-d9gxew91	392	54	Thorell	Thorell	NNP
cord-015910-d9gxew91	392	55	,	,	,
cord-015910-d9gxew91	392	56	et	et	NNP
cord-015910-d9gxew91	392	57	al	al	NNP
cord-015910-d9gxew91	392	58	.	.	NNP
cord-015910-d9gxew91	392	59	,	,	,
cord-015910-d9gxew91	392	60	2003	2003	CD
cord-015910-d9gxew91	392	61	)	)	-RRB-
cord-015910-d9gxew91	393	1	(	(	-LRB-
cord-015910-d9gxew91	393	2	Table	table	NN
cord-015910-d9gxew91	393	3	3	3	CD
cord-015910-d9gxew91	393	4	)	)	-RRB-
cord-015910-d9gxew91	393	5	.	.	.
cord-015910-d9gxew91	394	1	As	as	IN
cord-015910-d9gxew91	394	2	outlined	outline	VBN
cord-015910-d9gxew91	394	3	in	in	IN
cord-015910-d9gxew91	394	4	the	the	DT
cord-015910-d9gxew91	394	5	preceding	precede	VBG
cord-015910-d9gxew91	394	6	sections	section	NNS
cord-015910-d9gxew91	394	7	,	,	,
cord-015910-d9gxew91	394	8	the	the	DT
cord-015910-d9gxew91	394	9	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	394	10	response	response	NN
cord-015910-d9gxew91	394	11	,	,	,
cord-015910-d9gxew91	394	12	although	although	IN
cord-015910-d9gxew91	394	13	essential	essential	JJ
cord-015910-d9gxew91	394	14	for	for	IN
cord-015910-d9gxew91	394	15	survival	survival	NN
cord-015910-d9gxew91	394	16	in	in	IN
cord-015910-d9gxew91	394	17	the	the	DT
cord-015910-d9gxew91	394	18	presence	presence	NN
cord-015910-d9gxew91	394	19	of	of	IN
cord-015910-d9gxew91	394	20	pathogens	pathogen	NNS
cord-015910-d9gxew91	394	21	,	,	,
cord-015910-d9gxew91	394	22	can	can	MD
cord-015910-d9gxew91	394	23	exert	exert	VB
cord-015910-d9gxew91	394	24	deleterious	deleterious	JJ
cord-015910-d9gxew91	394	25	effects	effect	NNS
cord-015910-d9gxew91	394	26	on	on	IN
cord-015910-d9gxew91	394	27	the	the	DT
cord-015910-d9gxew91	394	28	host	host	NN
cord-015910-d9gxew91	394	29	.	.	.
cord-015910-d9gxew91	395	1	The	the	DT
cord-015910-d9gxew91	395	2	clear	clear	JJ
cord-015910-d9gxew91	395	3	need	need	NN
cord-015910-d9gxew91	395	4	to	to	TO
cord-015910-d9gxew91	395	5	find	find	VB
cord-015910-d9gxew91	395	6	ways	way	NNS
cord-015910-d9gxew91	395	7	of	of	IN
cord-015910-d9gxew91	395	8	modulating	modulate	VBG
cord-015910-d9gxew91	395	9	cytokine	cytokine	NN
cord-015910-d9gxew91	395	10	production	production	NN
cord-015910-d9gxew91	395	11	and	and	CC
cord-015910-d9gxew91	395	12	other	other	JJ
cord-015910-d9gxew91	395	13	aspects	aspect	NNS
cord-015910-d9gxew91	395	14	of	of	IN
cord-015910-d9gxew91	395	15	inflammation	inflammation	NN
cord-015910-d9gxew91	395	16	has	have	VBZ
cord-015910-d9gxew91	395	17	fostered	foster	VBN
cord-015910-d9gxew91	395	18	the	the	DT
cord-015910-d9gxew91	395	19	research	research	NN
cord-015910-d9gxew91	395	20	area	area	NN
cord-015910-d9gxew91	395	21	of	of	IN
cord-015910-d9gxew91	395	22	immunonutrition	immunonutrition	NN
cord-015910-d9gxew91	395	23	.	.	.
cord-015910-d9gxew91	396	1	In	in	IN
cord-015910-d9gxew91	396	2	a	a	DT
cord-015910-d9gxew91	396	3	clinical	clinical	JJ
cord-015910-d9gxew91	396	4	context	context	NN
cord-015910-d9gxew91	396	5	the	the	DT
cord-015910-d9gxew91	396	6	purpose	purpose	NN
cord-015910-d9gxew91	396	7	of	of	IN
cord-015910-d9gxew91	396	8	immunonutrition	immunonutrition	NN
cord-015910-d9gxew91	396	9	is	be	VBZ
cord-015910-d9gxew91	396	10	to	to	TO
cord-015910-d9gxew91	396	11	find	find	VB
cord-015910-d9gxew91	396	12	nutritional	nutritional	JJ
cord-015910-d9gxew91	396	13	means	mean	NNS
cord-015910-d9gxew91	396	14	of	of	IN
cord-015910-d9gxew91	396	15	altering	alter	VBG
cord-015910-d9gxew91	396	16	the	the	DT
cord-015910-d9gxew91	396	17	patient	patient	NN
cord-015910-d9gxew91	396	18	'	'	POS
cord-015910-d9gxew91	396	19	s	s	POS
cord-015910-d9gxew91	396	20	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	396	21	response	response	NN
cord-015910-d9gxew91	396	22	to	to	IN
cord-015910-d9gxew91	396	23	infection	infection	NN
cord-015910-d9gxew91	396	24	and	and	CC
cord-015910-d9gxew91	396	25	injury	injury	NN
cord-015910-d9gxew91	396	26	,	,	,
cord-015910-d9gxew91	396	27	from	from	IN
cord-015910-d9gxew91	396	28	the	the	DT
cord-015910-d9gxew91	396	29	detrimental	detrimental	JJ
cord-015910-d9gxew91	396	30	to	to	IN
cord-015910-d9gxew91	396	31	the	the	DT
cord-015910-d9gxew91	396	32	beneficial	beneficial	JJ
cord-015910-d9gxew91	396	33	side	side	NN
cord-015910-d9gxew91	396	34	of	of	IN
cord-015910-d9gxew91	396	35	the	the	DT
cord-015910-d9gxew91	396	36	pivot	pivot	NN
cord-015910-d9gxew91	396	37	on	on	IN
cord-015910-d9gxew91	396	38	which	which	WDT
cord-015910-d9gxew91	396	39	an	an	DT
cord-015910-d9gxew91	396	40	individual	individual	NN
cord-015910-d9gxew91	396	41	undergoing	undergo	VBG
cord-015910-d9gxew91	396	42	a	a	DT
cord-015910-d9gxew91	396	43	response	response	NN
cord-015910-d9gxew91	396	44	is	be	VBZ
cord-015910-d9gxew91	396	45	positioned	position	VBN
cord-015910-d9gxew91	396	46	.	.	.
cord-015910-d9gxew91	397	1	While	while	IN
cord-015910-d9gxew91	397	2	inflammation	inflammation	NN
cord-015910-d9gxew91	397	3	may	may	MD
cord-015910-d9gxew91	397	4	be	be	VB
cord-015910-d9gxew91	397	5	exerting	exert	VBG
cord-015910-d9gxew91	397	6	deleterious	deleterious	JJ
cord-015910-d9gxew91	397	7	effects	effect	NNS
cord-015910-d9gxew91	397	8	most	most	RBS
cord-015910-d9gxew91	397	9	obviously	obviously	RB
cord-015910-d9gxew91	397	10	in	in	IN
cord-015910-d9gxew91	397	11	patients	patient	NNS
cord-015910-d9gxew91	397	12	,	,	,
cord-015910-d9gxew91	397	13	people	people	NNS
cord-015910-d9gxew91	397	14	on	on	IN
cord-015910-d9gxew91	397	15	the	the	DT
cord-015910-d9gxew91	397	16	borderline	borderline	NN
cord-015910-d9gxew91	397	17	of	of	IN
cord-015910-d9gxew91	397	18	health	health	NN
cord-015910-d9gxew91	397	19	and	and	CC
cord-015910-d9gxew91	397	20	disease	disease	NN
cord-015910-d9gxew91	397	21	living	live	VBG
cord-015910-d9gxew91	397	22	in	in	IN
cord-015910-d9gxew91	397	23	the	the	DT
cord-015910-d9gxew91	397	24	general	general	JJ
cord-015910-d9gxew91	397	25	population	population	NN
cord-015910-d9gxew91	397	26	Table	Table	NNP
cord-015910-d9gxew91	397	27	4	4	CD
cord-015910-d9gxew91	397	28	Nutrients	nutrient	NNS
cord-015910-d9gxew91	397	29	Commonly	commonly	RB
cord-015910-d9gxew91	397	30	Used	use	VBN
cord-015910-d9gxew91	397	31	in	in	IN
cord-015910-d9gxew91	397	32	Immunonutrient	Immunonutrient	NNP
cord-015910-d9gxew91	397	33	Supplements	Supplements	NNPS
cord-015910-d9gxew91	397	34	and	and	CC
cord-015910-d9gxew91	397	35	Their	-PRON-	PRP$
cord-015910-d9gxew91	397	36	Potential	Potential	NNP
cord-015910-d9gxew91	397	37	Mode	Mode	NNP
cord-015910-d9gxew91	397	38	of	of	IN
cord-015910-d9gxew91	397	39	Action	action	NN
cord-015910-d9gxew91	398	1	•	•	NNP
cord-015910-d9gxew91	399	1	n-3	n-3	JJ
cord-015910-d9gxew91	399	2	polyunsaturated	polyunsaturated	JJ
cord-015910-d9gxew91	399	3	fatty	fatty	JJ
cord-015910-d9gxew91	399	4	acids	acid	NNS
cord-015910-d9gxew91	399	5	:	:	:
cord-015910-d9gxew91	399	6	act	act	VB
cord-015910-d9gxew91	399	7	as	as	IN
cord-015910-d9gxew91	399	8	anti	anti	JJ
cord-015910-d9gxew91	399	9	-	-	JJ
cord-015910-d9gxew91	399	10	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	399	11	agents	agent	NNS
cord-015910-d9gxew91	399	12	and	and	CC
cord-015910-d9gxew91	399	13	reverse	reverse	VB
cord-015910-d9gxew91	399	14	immunosuppression	immunosuppression	NN
cord-015910-d9gxew91	400	1	•	•	NNP
cord-015910-d9gxew91	401	1	Sulfur	sulfur	NN
cord-015910-d9gxew91	401	2	amino	amino	NN
cord-015910-d9gxew91	401	3	acids	acid	NNS
cord-015910-d9gxew91	401	4	and	and	CC
cord-015910-d9gxew91	401	5	their	-PRON-	PRP$
cord-015910-d9gxew91	401	6	precursors	precursor	NNS
cord-015910-d9gxew91	401	7	:	:	:
cord-015910-d9gxew91	401	8	enhance	enhance	VB
cord-015910-d9gxew91	401	9	antioxidant	antioxidant	NN
cord-015910-d9gxew91	401	10	status	status	NN
cord-015910-d9gxew91	401	11	via	via	IN
cord-015910-d9gxew91	401	12	GSH	GSH	NNP
cord-015910-d9gxew91	401	13	synthesis	synthesis	NN
cord-015910-d9gxew91	402	1	•	•	NNP
cord-015910-d9gxew91	402	2	Glutamine	glutamine	NN
cord-015910-d9gxew91	402	3	:	:	:
cord-015910-d9gxew91	402	4	nutrient	nutrient	NN
cord-015910-d9gxew91	402	5	for	for	IN
cord-015910-d9gxew91	402	6	immune	immune	JJ
cord-015910-d9gxew91	402	7	cells	cell	NNS
cord-015910-d9gxew91	402	8	,	,	,
cord-015910-d9gxew91	402	9	improves	improve	VBZ
cord-015910-d9gxew91	402	10	gut	gut	NN
cord-015910-d9gxew91	402	11	barrier	barrier	NN
cord-015910-d9gxew91	402	12	function	function	NN
cord-015910-d9gxew91	402	13	,	,	,
cord-015910-d9gxew91	402	14	precursor	precursor	NN
cord-015910-d9gxew91	402	15	for	for	IN
cord-015910-d9gxew91	402	16	GSH	GSH	NNP
cord-015910-d9gxew91	403	1	•	•	NNP
cord-015910-d9gxew91	403	2	Arginine	arginine	NN
cord-015910-d9gxew91	403	3	:	:	:
cord-015910-d9gxew91	403	4	stimulates	stimulate	VBZ
cord-015910-d9gxew91	403	5	nitric	nitric	NN
cord-015910-d9gxew91	403	6	oxide	oxide	NN
cord-015910-d9gxew91	403	7	and	and	CC
cord-015910-d9gxew91	403	8	growth	growth	NN
cord-015910-d9gxew91	403	9	hormone	hormone	NN
cord-015910-d9gxew91	403	10	production	production	NN
cord-015910-d9gxew91	403	11	,	,	,
cord-015910-d9gxew91	403	12	improves	improve	VBZ
cord-015910-d9gxew91	403	13	helper	helper	NN
cord-015910-d9gxew91	403	14	T	t	NN
cord-015910-d9gxew91	403	15	-	-	HYPH
cord-015910-d9gxew91	403	16	cell	cell	NN
cord-015910-d9gxew91	403	17	numbers	number	NNS
cord-015910-d9gxew91	404	1	•	•	NNP
cord-015910-d9gxew91	405	1	Nucleotides	nucleotide	NNS
cord-015910-d9gxew91	405	2	:	:	:
cord-015910-d9gxew91	405	3	RNA	rna	NN
cord-015910-d9gxew91	405	4	and	and	CC
cord-015910-d9gxew91	405	5	DNA	dna	NN
cord-015910-d9gxew91	405	6	precursors	precursor	NNS
cord-015910-d9gxew91	405	7	,	,	,
cord-015910-d9gxew91	405	8	improve	improve	VB
cord-015910-d9gxew91	405	9	T	t	NN
cord-015910-d9gxew91	405	10	-	-	HYPH
cord-015910-d9gxew91	405	11	cell	cell	NN
cord-015910-d9gxew91	405	12	function	function	NN
cord-015910-d9gxew91	405	13	may	may	MD
cord-015910-d9gxew91	405	14	also	also	RB
cord-015910-d9gxew91	405	15	require	require	VB
cord-015910-d9gxew91	405	16	nutritional	nutritional	JJ
cord-015910-d9gxew91	405	17	modulation	modulation	NN
cord-015910-d9gxew91	405	18	of	of	IN
cord-015910-d9gxew91	405	19	ongoing	ongoing	JJ
cord-015910-d9gxew91	405	20	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	405	21	processes	process	NNS
cord-015910-d9gxew91	405	22	.	.	.
cord-015910-d9gxew91	406	1	During	during	IN
cord-015910-d9gxew91	406	2	the	the	DT
cord-015910-d9gxew91	406	3	last	last	JJ
cord-015910-d9gxew91	406	4	20	20	CD
cord-015910-d9gxew91	406	5	years	year	NNS
cord-015910-d9gxew91	406	6	the	the	DT
cord-015910-d9gxew91	406	7	pace	pace	NN
cord-015910-d9gxew91	406	8	of	of	IN
cord-015910-d9gxew91	406	9	evolution	evolution	NN
cord-015910-d9gxew91	406	10	ofimmunomodulatory	ofimmunomodulatory	NN
cord-015910-d9gxew91	406	11	feeds	feed	VBZ
cord-015910-d9gxew91	406	12	and	and	CC
cord-015910-d9gxew91	406	13	intravenous	intravenous	JJ
cord-015910-d9gxew91	406	14	solutions	solution	NNS
cord-015910-d9gxew91	406	15	has	have	VBZ
cord-015910-d9gxew91	406	16	accelerated	accelerate	VBN
cord-015910-d9gxew91	406	17	.	.	.
cord-015910-d9gxew91	407	1	These	these	DT
cord-015910-d9gxew91	407	2	products	product	NNS
cord-015910-d9gxew91	407	3	contain	contain	VBP
cord-015910-d9gxew91	407	4	combinations	combination	NNS
cord-015910-d9gxew91	407	5	of	of	IN
cord-015910-d9gxew91	407	6	a	a	DT
cord-015910-d9gxew91	407	7	number	number	NN
cord-015910-d9gxew91	407	8	of	of	IN
cord-015910-d9gxew91	407	9	components	component	NNS
cord-015910-d9gxew91	407	10	to	to	TO
cord-015910-d9gxew91	407	11	which	which	WDT
cord-015910-d9gxew91	407	12	various	various	JJ
cord-015910-d9gxew91	407	13	functional	functional	JJ
cord-015910-d9gxew91	407	14	attributes	attribute	NNS
cord-015910-d9gxew91	407	15	are	be	VBP
cord-015910-d9gxew91	407	16	ascribed	ascribe	VBN
cord-015910-d9gxew91	407	17	them	-PRON-	PRP
cord-015910-d9gxew91	407	18	(	(	-LRB-
cord-015910-d9gxew91	407	19	Table	table	NN
cord-015910-d9gxew91	407	20	4	4	CD
cord-015910-d9gxew91	407	21	)	)	-RRB-
cord-015910-d9gxew91	407	22	(	(	-LRB-
cord-015910-d9gxew91	407	23	Grimble	Grimble	NNP
cord-015910-d9gxew91	407	24	,	,	,
cord-015910-d9gxew91	407	25	2001a	2001a	CD
cord-015910-d9gxew91	407	26	)	)	-RRB-
cord-015910-d9gxew91	407	27	.	.	.
cord-015910-d9gxew91	408	1	Many	many	JJ
cord-015910-d9gxew91	408	2	studies	study	NNS
cord-015910-d9gxew91	408	3	have	have	VBP
cord-015910-d9gxew91	408	4	indicated	indicate	VBN
cord-015910-d9gxew91	408	5	that	that	IN
cord-015910-d9gxew91	408	6	n-3	n-3	JJ
cord-015910-d9gxew91	408	7	polyunsaturated	polyunsaturated	JJ
cord-015910-d9gxew91	408	8	fatty	fatty	JJ
cord-015910-d9gxew91	408	9	acids	acid	NNS
cord-015910-d9gxew91	408	10	(	(	-LRB-
cord-015910-d9gxew91	408	11	PUFAs	pufa	NNS
cord-015910-d9gxew91	408	12	)	)	-RRB-
cord-015910-d9gxew91	408	13	,	,	,
cord-015910-d9gxew91	408	14	glutamine	glutamine	NN
cord-015910-d9gxew91	408	15	,	,	,
cord-015910-d9gxew91	408	16	arginine	arginine	NN
cord-015910-d9gxew91	408	17	,	,	,
cord-015910-d9gxew91	408	18	sulfur	sulfur	NN
cord-015910-d9gxew91	408	19	amino	amino	NN
cord-015910-d9gxew91	408	20	acids	acid	NNS
cord-015910-d9gxew91	408	21	,	,	,
cord-015910-d9gxew91	408	22	and	and	CC
cord-015910-d9gxew91	408	23	nucleotides	nucleotide	NNS
cord-015910-d9gxew91	408	24	are	be	VBP
cord-015910-d9gxew91	408	25	all	all	DT
cord-015910-d9gxew91	408	26	potentially	potentially	RB
cord-015910-d9gxew91	408	27	capable	capable	JJ
cord-015910-d9gxew91	408	28	of	of	IN
cord-015910-d9gxew91	408	29	shifting	shift	VBG
cord-015910-d9gxew91	408	30	the	the	DT
cord-015910-d9gxew91	408	31	balance	balance	NN
cord-015910-d9gxew91	408	32	from	from	IN
cord-015910-d9gxew91	408	33	a	a	DT
cord-015910-d9gxew91	408	34	disadvantageous	disadvantageous	JJ
cord-015910-d9gxew91	408	35	to	to	IN
cord-015910-d9gxew91	408	36	an	an	DT
cord-015910-d9gxew91	408	37	advantageous	advantageous	JJ
cord-015910-d9gxew91	408	38	response	response	NN
cord-015910-d9gxew91	408	39	to	to	IN
cord-015910-d9gxew91	408	40	infection	infection	NN
cord-015910-d9gxew91	408	41	and	and	CC
cord-015910-d9gxew91	408	42	injury	injury	NN
cord-015910-d9gxew91	408	43	.	.	.
cord-015910-d9gxew91	409	1	The	the	DT
cord-015910-d9gxew91	409	2	examples	example	NNS
cord-015910-d9gxew91	409	3	used	use	VBN
cord-015910-d9gxew91	409	4	here	here	RB
cord-015910-d9gxew91	409	5	are	be	VBP
cord-015910-d9gxew91	409	6	illustrative	illustrative	JJ
cord-015910-d9gxew91	409	7	rather	rather	RB
cord-015910-d9gxew91	409	8	than	than	IN
cord-015910-d9gxew91	409	9	comprehensive	comprehensive	JJ
cord-015910-d9gxew91	409	10	.	.	.
cord-015910-d9gxew91	410	1	A	a	DT
cord-015910-d9gxew91	410	2	number	number	NN
cord-015910-d9gxew91	410	3	of	of	IN
cord-015910-d9gxew91	410	4	studies	study	NNS
cord-015910-d9gxew91	410	5	indicate	indicate	VBP
cord-015910-d9gxew91	410	6	that	that	IN
cord-015910-d9gxew91	410	7	improvement	improvement	NN
cord-015910-d9gxew91	410	8	of	of	IN
cord-015910-d9gxew91	410	9	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	410	10	status	status	NN
cord-015910-d9gxew91	410	11	is	be	VBZ
cord-015910-d9gxew91	410	12	associated	associate	VBN
cord-015910-d9gxew91	410	13	with	with	IN
cord-015910-d9gxew91	410	14	an	an	DT
cord-015910-d9gxew91	410	15	increase	increase	NN
cord-015910-d9gxew91	410	16	in	in	IN
cord-015910-d9gxew91	410	17	cellular	cellular	JJ
cord-015910-d9gxew91	410	18	aspects	aspect	NNS
cord-015910-d9gxew91	410	19	of	of	IN
cord-015910-d9gxew91	410	20	immune	immune	JJ
cord-015910-d9gxew91	410	21	function	function	NN
cord-015910-d9gxew91	410	22	.	.	.
cord-015910-d9gxew91	411	1	Meta	Meta	NNP
cord-015910-d9gxew91	411	2	-	-	HYPH
cord-015910-d9gxew91	411	3	analyses	analysis	NNS
cord-015910-d9gxew91	411	4	have	have	VBP
cord-015910-d9gxew91	411	5	been	be	VBN
cord-015910-d9gxew91	411	6	conducted	conduct	VBN
cord-015910-d9gxew91	411	7	on	on	IN
cord-015910-d9gxew91	411	8	the	the	DT
cord-015910-d9gxew91	411	9	efficacy	efficacy	NN
cord-015910-d9gxew91	411	10	of	of	IN
cord-015910-d9gxew91	411	11	immunonutrients	immunonutrient	NNS
cord-015910-d9gxew91	411	12	that	that	WDT
cord-015910-d9gxew91	411	13	influence	influence	VBP
cord-015910-d9gxew91	411	14	antioxidant	antioxidant	NN
cord-015910-d9gxew91	411	15	status	status	NN
cord-015910-d9gxew91	411	16	.	.	.
cord-015910-d9gxew91	412	1	In	in	IN
cord-015910-d9gxew91	412	2	clinical	clinical	JJ
cord-015910-d9gxew91	412	3	trials	trial	NNS
cord-015910-d9gxew91	412	4	,	,	,
cord-015910-d9gxew91	412	5	indices	index	NNS
cord-015910-d9gxew91	412	6	such	such	JJ
cord-015910-d9gxew91	412	7	as	as	IN
cord-015910-d9gxew91	412	8	infection	infection	NN
cord-015910-d9gxew91	412	9	rates	rate	NNS
cord-015910-d9gxew91	412	10	,	,	,
cord-015910-d9gxew91	412	11	mortality	mortality	NN
cord-015910-d9gxew91	412	12	rates	rate	NNS
cord-015910-d9gxew91	412	13	,	,	,
cord-015910-d9gxew91	412	14	and	and	CC
cord-015910-d9gxew91	412	15	length	length	NN
cord-015910-d9gxew91	412	16	of	of	IN
cord-015910-d9gxew91	412	17	stay	stay	NN
cord-015910-d9gxew91	412	18	are	be	VBP
cord-015910-d9gxew91	412	19	often	often	RB
cord-015910-d9gxew91	412	20	measured	measure	VBN
cord-015910-d9gxew91	412	21	in	in	IN
cord-015910-d9gxew91	412	22	the	the	DT
cord-015910-d9gxew91	412	23	absence	absence	NN
cord-015910-d9gxew91	412	24	of	of	IN
cord-015910-d9gxew91	412	25	functional	functional	JJ
cord-015910-d9gxew91	412	26	and	and	CC
cord-015910-d9gxew91	412	27	biochemical	biochemical	JJ
cord-015910-d9gxew91	412	28	aspects	aspect	NNS
cord-015910-d9gxew91	412	29	of	of	IN
cord-015910-d9gxew91	412	30	the	the	DT
cord-015910-d9gxew91	412	31	response	response	NN
cord-015910-d9gxew91	412	32	,	,	,
cord-015910-d9gxew91	412	33	such	such	JJ
cord-015910-d9gxew91	412	34	as	as	IN
cord-015910-d9gxew91	412	35	T	t	NN
cord-015910-d9gxew91	412	36	-	-	HYPH
cord-015910-d9gxew91	412	37	cell	cell	NN
cord-015910-d9gxew91	412	38	function	function	NN
cord-015910-d9gxew91	412	39	,	,	,
cord-015910-d9gxew91	412	40	cytokine	cytokine	NN
cord-015910-d9gxew91	412	41	production	production	NN
cord-015910-d9gxew91	412	42	,	,	,
cord-015910-d9gxew91	412	43	and	and	CC
cord-015910-d9gxew91	412	44	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	412	45	status	status	NN
cord-015910-d9gxew91	412	46	,	,	,
cord-015910-d9gxew91	412	47	and	and	CC
cord-015910-d9gxew91	412	48	vice	vice	NN
cord-015910-d9gxew91	412	49	versa	versa	RB
cord-015910-d9gxew91	412	50	,	,	,
cord-015910-d9gxew91	412	51	giving	give	VBG
cord-015910-d9gxew91	412	52	a	a	DT
cord-015910-d9gxew91	412	53	rather	rather	RB
cord-015910-d9gxew91	412	54	incomplete	incomplete	JJ
cord-015910-d9gxew91	412	55	picture	picture	NN
cord-015910-d9gxew91	412	56	of	of	IN
cord-015910-d9gxew91	412	57	the	the	DT
cord-015910-d9gxew91	412	58	mechanisms	mechanism	NNS
cord-015910-d9gxew91	412	59	of	of	IN
cord-015910-d9gxew91	412	60	any	any	DT
cord-015910-d9gxew91	412	61	observed	observed	JJ
cord-015910-d9gxew91	412	62	effects	effect	NNS
cord-015910-d9gxew91	412	63	of	of	IN
cord-015910-d9gxew91	412	64	immunonutrition	immunonutrition	NN
cord-015910-d9gxew91	412	65	.	.	.
cord-015910-d9gxew91	413	1	However	however	RB
cord-015910-d9gxew91	413	2	,	,	,
cord-015910-d9gxew91	413	3	Beale	Beale	NNP
cord-015910-d9gxew91	413	4	,	,	,
cord-015910-d9gxew91	413	5	Bryg	Bryg	NNP
cord-015910-d9gxew91	413	6	,	,	,
cord-015910-d9gxew91	413	7	&	&	CC
cord-015910-d9gxew91	413	8	Bihari	Bihari	NNP
cord-015910-d9gxew91	413	9	(	(	-LRB-
cord-015910-d9gxew91	413	10	1999	1999	CD
cord-015910-d9gxew91	413	11	)	)	-RRB-
cord-015910-d9gxew91	413	12	,	,	,
cord-015910-d9gxew91	413	13	in	in	IN
cord-015910-d9gxew91	413	14	a	a	DT
cord-015910-d9gxew91	413	15	meta	meta	JJ
cord-015910-d9gxew91	413	16	-	-	HYPH
cord-015910-d9gxew91	413	17	analysis	analysis	NN
cord-015910-d9gxew91	413	18	of	of	IN
cord-015910-d9gxew91	413	19	12	12	CD
cord-015910-d9gxew91	413	20	studies	study	NNS
cord-015910-d9gxew91	413	21	containing	contain	VBG
cord-015910-d9gxew91	413	22	more	more	JJR
cord-015910-d9gxew91	413	23	than	than	IN
cord-015910-d9gxew91	413	24	1400	1400	CD
cord-015910-d9gxew91	413	25	patients	patient	NNS
cord-015910-d9gxew91	413	26	receiving	receive	VBG
cord-015910-d9gxew91	413	27	enteral	enteral	JJ
cord-015910-d9gxew91	413	28	immunonutrition	immunonutrition	NN
cord-015910-d9gxew91	413	29	,	,	,
cord-015910-d9gxew91	413	30	observed	observe	VBD
cord-015910-d9gxew91	413	31	that	that	IN
cord-015910-d9gxew91	413	32	although	although	IN
cord-015910-d9gxew91	413	33	there	there	EX
cord-015910-d9gxew91	413	34	was	be	VBD
cord-015910-d9gxew91	413	35	no	no	DT
cord-015910-d9gxew91	413	36	effect	effect	NN
cord-015910-d9gxew91	413	37	upon	upon	IN
cord-015910-d9gxew91	413	38	mortality	mortality	NN
cord-015910-d9gxew91	413	39	,	,	,
cord-015910-d9gxew91	413	40	there	there	EX
cord-015910-d9gxew91	413	41	were	be	VBD
cord-015910-d9gxew91	413	42	significant	significant	JJ
cord-015910-d9gxew91	413	43	reductions	reduction	NNS
cord-015910-d9gxew91	413	44	in	in	IN
cord-015910-d9gxew91	413	45	infection	infection	NN
cord-015910-d9gxew91	413	46	rates	rate	NNS
cord-015910-d9gxew91	413	47	,	,	,
cord-015910-d9gxew91	413	48	time	time	NN
cord-015910-d9gxew91	413	49	spent	spend	VBN
cord-015910-d9gxew91	413	50	on	on	IN
cord-015910-d9gxew91	413	51	a	a	DT
cord-015910-d9gxew91	413	52	ventilator	ventilator	NN
cord-015910-d9gxew91	413	53	,	,	,
cord-015910-d9gxew91	413	54	and	and	CC
cord-015910-d9gxew91	413	55	length	length	NN
cord-015910-d9gxew91	413	56	of	of	IN
cord-015910-d9gxew91	413	57	hospital	hospital	NN
cord-015910-d9gxew91	413	58	stay	stay	NN
cord-015910-d9gxew91	413	59	.	.	.
cord-015910-d9gxew91	414	1	While	while	IN
cord-015910-d9gxew91	414	2	this	this	DT
cord-015910-d9gxew91	414	3	finding	finding	NN
cord-015910-d9gxew91	414	4	indicates	indicate	VBZ
cord-015910-d9gxew91	414	5	that	that	IN
cord-015910-d9gxew91	414	6	immunonutrition	immunonutrition	NN
cord-015910-d9gxew91	414	7	may	may	MD
cord-015910-d9gxew91	414	8	be	be	VB
cord-015910-d9gxew91	414	9	useful	useful	JJ
cord-015910-d9gxew91	414	10	in	in	IN
cord-015910-d9gxew91	414	11	modulating	modulate	VBG
cord-015910-d9gxew91	414	12	the	the	DT
cord-015910-d9gxew91	414	13	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	414	14	process	process	NN
cord-015910-d9gxew91	414	15	in	in	IN
cord-015910-d9gxew91	414	16	patients	patient	NNS
cord-015910-d9gxew91	414	17	experiencing	experience	VBG
cord-015910-d9gxew91	414	18	severe	severe	JJ
cord-015910-d9gxew91	414	19	inflammation	inflammation	NN
cord-015910-d9gxew91	414	20	,	,	,
cord-015910-d9gxew91	414	21	the	the	DT
cord-015910-d9gxew91	414	22	consistency	consistency	NN
cord-015910-d9gxew91	414	23	of	of	IN
cord-015910-d9gxew91	414	24	the	the	DT
cord-015910-d9gxew91	414	25	effects	effect	NNS
cord-015910-d9gxew91	414	26	observed	observe	VBN
cord-015910-d9gxew91	414	27	was	be	VBD
cord-015910-d9gxew91	414	28	disappointing	disappointing	JJ
cord-015910-d9gxew91	414	29	.	.	.
cord-015910-d9gxew91	415	1	There	there	EX
cord-015910-d9gxew91	415	2	are	be	VBP
cord-015910-d9gxew91	415	3	at	at	RB
cord-015910-d9gxew91	415	4	least	least	RBS
cord-015910-d9gxew91	415	5	three	three	CD
cord-015910-d9gxew91	415	6	major	major	JJ
cord-015910-d9gxew91	415	7	reasons	reason	NNS
cord-015910-d9gxew91	415	8	why	why	WRB
cord-015910-d9gxew91	415	9	it	-PRON-	PRP
cord-015910-d9gxew91	415	10	is	be	VBZ
cord-015910-d9gxew91	415	11	difficult	difficult	JJ
cord-015910-d9gxew91	415	12	to	to	TO
cord-015910-d9gxew91	415	13	demonstrate	demonstrate	VB
cord-015910-d9gxew91	415	14	a	a	DT
cord-015910-d9gxew91	415	15	consistent	consistent	JJ
cord-015910-d9gxew91	415	16	effect	effect	NN
cord-015910-d9gxew91	415	17	.	.	.
cord-015910-d9gxew91	416	1	First	first	RB
cord-015910-d9gxew91	416	2	,	,	,
cord-015910-d9gxew91	416	3	patients	patient	NNS
cord-015910-d9gxew91	416	4	used	use	VBN
cord-015910-d9gxew91	416	5	as	as	IN
cord-015910-d9gxew91	416	6	the	the	DT
cord-015910-d9gxew91	416	7	subjects	subject	NNS
cord-015910-d9gxew91	416	8	of	of	IN
cord-015910-d9gxew91	416	9	clinical	clinical	JJ
cord-015910-d9gxew91	416	10	trials	trial	NNS
cord-015910-d9gxew91	416	11	of	of	IN
cord-015910-d9gxew91	416	12	immunonutrients	immunonutrient	NNS
cord-015910-d9gxew91	416	13	will	will	MD
cord-015910-d9gxew91	416	14	constitute	constitute	VB
cord-015910-d9gxew91	416	15	a	a	DT
cord-015910-d9gxew91	416	16	diverse	diverse	JJ
cord-015910-d9gxew91	416	17	population	population	NN
cord-015910-d9gxew91	416	18	--	--	:
cord-015910-d9gxew91	416	19	different	different	JJ
cord-015910-d9gxew91	416	20	ages	age	NNS
cord-015910-d9gxew91	416	21	,	,	,
cord-015910-d9gxew91	416	22	at	at	IN
cord-015910-d9gxew91	416	23	different	different	JJ
cord-015910-d9gxew91	416	24	stages	stage	NNS
cord-015910-d9gxew91	416	25	of	of	IN
cord-015910-d9gxew91	416	26	a	a	DT
cord-015910-d9gxew91	416	27	disease	disease	NN
cord-015910-d9gxew91	416	28	process	process	NN
cord-015910-d9gxew91	416	29	,	,	,
cord-015910-d9gxew91	416	30	and	and	CC
cord-015910-d9gxew91	416	31	undergoing	undergo	VBG
cord-015910-d9gxew91	416	32	complex	complex	JJ
cord-015910-d9gxew91	416	33	clinical	clinical	JJ
cord-015910-d9gxew91	416	34	treatment	treatment	NN
cord-015910-d9gxew91	416	35	in	in	IN
cord-015910-d9gxew91	416	36	addition	addition	NN
cord-015910-d9gxew91	416	37	to	to	IN
cord-015910-d9gxew91	416	38	nutrient	nutrient	NN
cord-015910-d9gxew91	416	39	therapy	therapy	NN
cord-015910-d9gxew91	416	40	.	.	.
cord-015910-d9gxew91	417	1	Second	second	RB
cord-015910-d9gxew91	417	2	,	,	,
cord-015910-d9gxew91	417	3	patients	patient	NNS
cord-015910-d9gxew91	417	4	will	will	MD
cord-015910-d9gxew91	417	5	have	have	VB
cord-015910-d9gxew91	417	6	differing	differ	VBG
cord-015910-d9gxew91	417	7	genetic	genetic	JJ
cord-015910-d9gxew91	417	8	backgrounds	background	NNS
cord-015910-d9gxew91	417	9	that	that	WDT
cord-015910-d9gxew91	417	10	will	will	MD
cord-015910-d9gxew91	417	11	influence	influence	VB
cord-015910-d9gxew91	417	12	the	the	DT
cord-015910-d9gxew91	417	13	intensity	intensity	NN
cord-015910-d9gxew91	417	14	of	of	IN
cord-015910-d9gxew91	417	15	the	the	DT
cord-015910-d9gxew91	417	16	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	417	17	and	and	CC
cord-015910-d9gxew91	417	18	immune	immune	JJ
cord-015910-d9gxew91	417	19	responses	response	NNS
cord-015910-d9gxew91	417	20	they	-PRON-	PRP
cord-015910-d9gxew91	417	21	are	be	VBP
cord-015910-d9gxew91	417	22	undergoing	undergo	VBG
cord-015910-d9gxew91	417	23	.	.	.
cord-015910-d9gxew91	418	1	This	this	DT
cord-015910-d9gxew91	418	2	issue	issue	NN
cord-015910-d9gxew91	418	3	is	be	VBZ
cord-015910-d9gxew91	418	4	dealt	deal	VBN
cord-015910-d9gxew91	418	5	with	with	IN
cord-015910-d9gxew91	418	6	below	below	RB
cord-015910-d9gxew91	418	7	.	.	.
cord-015910-d9gxew91	419	1	Third	third	RB
cord-015910-d9gxew91	419	2	,	,	,
cord-015910-d9gxew91	419	3	nutrients	nutrient	NNS
cord-015910-d9gxew91	419	4	may	may	MD
cord-015910-d9gxew91	419	5	exert	exert	VB
cord-015910-d9gxew91	419	6	paradoxical	paradoxical	JJ
cord-015910-d9gxew91	419	7	effects	effect	NNS
cord-015910-d9gxew91	419	8	,	,	,
cord-015910-d9gxew91	419	9	as	as	IN
cord-015910-d9gxew91	419	10	illustrated	illustrate	VBN
cord-015910-d9gxew91	419	11	by	by	IN
cord-015910-d9gxew91	419	12	the	the	DT
cord-015910-d9gxew91	419	13	findings	finding	NNS
cord-015910-d9gxew91	419	14	of	of	IN
cord-015910-d9gxew91	419	15	the	the	DT
cord-015910-d9gxew91	419	16	first	first	JJ
cord-015910-d9gxew91	419	17	observations	observation	NNS
cord-015910-d9gxew91	419	18	of	of	IN
cord-015910-d9gxew91	419	19	the	the	DT
cord-015910-d9gxew91	419	20	effects	effect	NNS
cord-015910-d9gxew91	419	21	of	of	IN
cord-015910-d9gxew91	419	22	fish	fish	NN
cord-015910-d9gxew91	419	23	oil	oil	NN
cord-015910-d9gxew91	419	24	on	on	IN
cord-015910-d9gxew91	419	25	cytokine	cytokine	NN
cord-015910-d9gxew91	419	26	production	production	NN
cord-015910-d9gxew91	419	27	in	in	IN
cord-015910-d9gxew91	419	28	healthy	healthy	JJ
cord-015910-d9gxew91	419	29	subjects	subject	NNS
cord-015910-d9gxew91	419	30	.	.	.
cord-015910-d9gxew91	420	1	The	the	DT
cord-015910-d9gxew91	420	2	findings	finding	NNS
cord-015910-d9gxew91	420	3	of	of	IN
cord-015910-d9gxew91	420	4	Endres	Endres	NNP
cord-015910-d9gxew91	420	5	et	et	FW
cord-015910-d9gxew91	420	6	al	al	NNP
cord-015910-d9gxew91	420	7	.	.	.
cord-015910-d9gxew91	421	1	(	(	-LRB-
cord-015910-d9gxew91	421	2	1989	1989	CD
cord-015910-d9gxew91	421	3	)	)	-RRB-
cord-015910-d9gxew91	421	4	that	that	IN
cord-015910-d9gxew91	421	5	a	a	DT
cord-015910-d9gxew91	421	6	daily	daily	JJ
cord-015910-d9gxew91	421	7	supplement	supplement	NN
cord-015910-d9gxew91	421	8	of	of	IN
cord-015910-d9gxew91	421	9	18	18	CD
cord-015910-d9gxew91	421	10	g	g	NN
cord-015910-d9gxew91	421	11	/	/	SYM
cord-015910-d9gxew91	421	12	d	d	NN
cord-015910-d9gxew91	421	13	of	of	IN
cord-015910-d9gxew91	421	14	fish	fish	NN
cord-015910-d9gxew91	421	15	oil	oil	NN
cord-015910-d9gxew91	421	16	given	give	VBN
cord-015910-d9gxew91	421	17	to	to	IN
cord-015910-d9gxew91	421	18	nine	nine	CD
cord-015910-d9gxew91	421	19	young	young	JJ
cord-015910-d9gxew91	421	20	men	man	NNS
cord-015910-d9gxew91	421	21	for	for	IN
cord-015910-d9gxew91	421	22	6	6	CD
cord-015910-d9gxew91	421	23	wk	wk	NN
cord-015910-d9gxew91	421	24	was	be	VBD
cord-015910-d9gxew91	421	25	able	able	JJ
cord-015910-d9gxew91	421	26	to	to	TO
cord-015910-d9gxew91	421	27	reduce	reduce	VB
cord-015910-d9gxew91	421	28	ex	ex	AFX
cord-015910-d9gxew91	421	29	vivo	vivo	NN
cord-015910-d9gxew91	421	30	production	production	NN
cord-015910-d9gxew91	421	31	oflL-1	oflL-1	NNP
cord-015910-d9gxew91	421	32	and	and	CC
cord-015910-d9gxew91	421	33	TNF-~	TNF-~	NNP
cord-015910-d9gxew91	421	34	by	by	IN
cord-015910-d9gxew91	421	35	LPS	LPS	NNP
cord-015910-d9gxew91	421	36	-	-	HYPH
cord-015910-d9gxew91	421	37	stimulated	stimulate	VBN
cord-015910-d9gxew91	421	38	PBMCs	pbmc	NNS
cord-015910-d9gxew91	421	39	aroused	arouse	VBD
cord-015910-d9gxew91	421	40	great	great	JJ
cord-015910-d9gxew91	421	41	interest	interest	NN
cord-015910-d9gxew91	421	42	in	in	IN
cord-015910-d9gxew91	421	43	fish	fish	NN
cord-015910-d9gxew91	421	44	oil	oil	NN
cord-015910-d9gxew91	421	45	as	as	IN
cord-015910-d9gxew91	421	46	an	an	DT
cord-015910-d9gxew91	421	47	anti	anti	JJ
cord-015910-d9gxew91	421	48	-	-	JJ
cord-015910-d9gxew91	421	49	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	421	50	nutrient	nutrient	NN
cord-015910-d9gxew91	421	51	.	.	.
cord-015910-d9gxew91	422	1	This	this	DT
cord-015910-d9gxew91	422	2	perception	perception	NN
cord-015910-d9gxew91	422	3	was	be	VBD
cord-015910-d9gxew91	422	4	supported	support	VBN
cord-015910-d9gxew91	422	5	by	by	IN
cord-015910-d9gxew91	422	6	a	a	DT
cord-015910-d9gxew91	422	7	large	large	JJ
cord-015910-d9gxew91	422	8	amount	amount	NN
cord-015910-d9gxew91	422	9	of	of	IN
cord-015910-d9gxew91	422	10	animal	animal	NN
cord-015910-d9gxew91	422	11	data	datum	NNS
cord-015910-d9gxew91	422	12	.	.	.
cord-015910-d9gxew91	423	1	However	however	RB
cord-015910-d9gxew91	423	2	,	,	,
cord-015910-d9gxew91	423	3	Endres	Endres	NNP
cord-015910-d9gxew91	423	4	'	'	POS
cord-015910-d9gxew91	423	5	data	datum	NNS
cord-015910-d9gxew91	423	6	showed	show	VBD
cord-015910-d9gxew91	423	7	a	a	DT
cord-015910-d9gxew91	423	8	wide	wide	JJ
cord-015910-d9gxew91	423	9	variability	variability	NN
cord-015910-d9gxew91	423	10	in	in	IN
cord-015910-d9gxew91	423	11	the	the	DT
cord-015910-d9gxew91	423	12	effect	effect	NN
cord-015910-d9gxew91	423	13	of	of	IN
cord-015910-d9gxew91	423	14	the	the	DT
cord-015910-d9gxew91	423	15	fish	fish	NN
cord-015910-d9gxew91	423	16	oil	oil	NN
cord-015910-d9gxew91	423	17	supplements	supplement	NNS
cord-015910-d9gxew91	423	18	.	.	.
cord-015910-d9gxew91	424	1	The	the	DT
cord-015910-d9gxew91	424	2	standard	standard	JJ
cord-015910-d9gxew91	424	3	deviations	deviation	NNS
cord-015910-d9gxew91	424	4	of	of	IN
cord-015910-d9gxew91	424	5	the	the	DT
cord-015910-d9gxew91	424	6	mean	mean	NN
cord-015910-d9gxew91	424	7	for	for	IN
cord-015910-d9gxew91	424	8	IL-113	IL-113	NNP
cord-015910-d9gxew91	424	9	and	and	CC
cord-015910-d9gxew91	424	10	TNF	TNF	NNP
cord-015910-d9gxew91	424	11	-	-	HYPH
cord-015910-d9gxew91	424	12	cx	cx	NNP
cord-015910-d9gxew91	424	13	production	production	NN
cord-015910-d9gxew91	424	14	were	be	VBD
cord-015910-d9gxew91	424	15	59	59	CD
cord-015910-d9gxew91	424	16	and	and	CC
cord-015910-d9gxew91	424	17	51	51	CD
cord-015910-d9gxew91	424	18	%	%	NN
cord-015910-d9gxew91	424	19	,	,	,
cord-015910-d9gxew91	424	20	respectively	respectively	RB
cord-015910-d9gxew91	424	21	.	.	.
cord-015910-d9gxew91	425	1	This	this	DT
cord-015910-d9gxew91	425	2	indicates	indicate	VBZ
cord-015910-d9gxew91	425	3	that	that	DT
cord-015910-d9gxew91	425	4	cytokine	cytokine	NN
cord-015910-d9gxew91	425	5	production	production	NN
cord-015910-d9gxew91	425	6	could	could	MD
cord-015910-d9gxew91	425	7	have	have	VB
cord-015910-d9gxew91	425	8	risen	rise	VBN
cord-015910-d9gxew91	425	9	or	or	CC
cord-015910-d9gxew91	425	10	fallen	fall	VBN
cord-015910-d9gxew91	425	11	as	as	IN
cord-015910-d9gxew91	425	12	a	a	DT
cord-015910-d9gxew91	425	13	consequence	consequence	NN
cord-015910-d9gxew91	425	14	of	of	IN
cord-015910-d9gxew91	425	15	taking	take	VBG
cord-015910-d9gxew91	425	16	the	the	DT
cord-015910-d9gxew91	425	17	supplement	supplement	NN
cord-015910-d9gxew91	425	18	.	.	.
cord-015910-d9gxew91	426	1	The	the	DT
cord-015910-d9gxew91	426	2	effects	effect	NNS
cord-015910-d9gxew91	426	3	of	of	IN
cord-015910-d9gxew91	426	4	supplementing	supplement	VBG
cord-015910-d9gxew91	426	5	116	116	CD
cord-015910-d9gxew91	426	6	healthy	healthy	JJ
cord-015910-d9gxew91	426	7	young	young	JJ
cord-015910-d9gxew91	426	8	men	man	NNS
cord-015910-d9gxew91	426	9	with	with	IN
cord-015910-d9gxew91	426	10	6	6	CD
cord-015910-d9gxew91	426	11	g	g	NN
cord-015910-d9gxew91	426	12	/	/	SYM
cord-015910-d9gxew91	426	13	d	d	NNP
cord-015910-d9gxew91	426	14	offish	offish	JJ
cord-015910-d9gxew91	426	15	oil	oil	NN
cord-015910-d9gxew91	426	16	for	for	IN
cord-015910-d9gxew91	426	17	12	12	CD
cord-015910-d9gxew91	426	18	wk	wk	NNS
cord-015910-d9gxew91	426	19	,	,	,
cord-015910-d9gxew91	426	20	on	on	IN
cord-015910-d9gxew91	426	21	TNF	TNF	NNP
cord-015910-d9gxew91	426	22	-	-	HYPH
cord-015910-d9gxew91	426	23	ct	ct	NNP
cord-015910-d9gxew91	426	24	production	production	NN
cord-015910-d9gxew91	426	25	by	by	IN
cord-015910-d9gxew91	426	26	PBMCs	pbmc	NNS
cord-015910-d9gxew91	426	27	stimulated	stimulate	VBN
cord-015910-d9gxew91	426	28	with	with	IN
cord-015910-d9gxew91	426	29	endotoxin	endotoxin	NN
cord-015910-d9gxew91	426	30	have	have	VBP
cord-015910-d9gxew91	426	31	been	be	VBN
cord-015910-d9gxew91	426	32	studied	study	VBN
cord-015910-d9gxew91	426	33	in	in	IN
cord-015910-d9gxew91	426	34	the	the	DT
cord-015910-d9gxew91	426	35	author	author	NN
cord-015910-d9gxew91	426	36	'	'	POS
cord-015910-d9gxew91	426	37	s	s	NNP
cord-015910-d9gxew91	426	38	laboratory	laboratory	NN
cord-015910-d9gxew91	426	39	.	.	.
cord-015910-d9gxew91	427	1	It	-PRON-	PRP
cord-015910-d9gxew91	427	2	was	be	VBD
cord-015910-d9gxew91	427	3	found	find	VBN
cord-015910-d9gxew91	427	4	that	that	IN
cord-015910-d9gxew91	427	5	51	51	CD
cord-015910-d9gxew91	427	6	%	%	NN
cord-015910-d9gxew91	427	7	of	of	IN
cord-015910-d9gxew91	427	8	subjects	subject	NNS
cord-015910-d9gxew91	427	9	experienced	experience	VBD
cord-015910-d9gxew91	427	10	a	a	DT
cord-015910-d9gxew91	427	11	fall	fall	NN
cord-015910-d9gxew91	427	12	in	in	IN
cord-015910-d9gxew91	427	13	production	production	NN
cord-015910-d9gxew91	427	14	and	and	CC
cord-015910-d9gxew91	427	15	49	49	CD
cord-015910-d9gxew91	427	16	%	%	NN
cord-015910-d9gxew91	427	17	a	a	DT
cord-015910-d9gxew91	427	18	rise	rise	NN
cord-015910-d9gxew91	427	19	.	.	.
cord-015910-d9gxew91	428	1	Although	although	IN
cord-015910-d9gxew91	428	2	the	the	DT
cord-015910-d9gxew91	428	3	ability	ability	NN
cord-015910-d9gxew91	428	4	of	of	IN
cord-015910-d9gxew91	428	5	fish	fish	NN
cord-015910-d9gxew91	428	6	oil	oil	NN
cord-015910-d9gxew91	428	7	to	to	TO
cord-015910-d9gxew91	428	8	increase	increase	VB
cord-015910-d9gxew91	428	9	TNF	TNF	NNP
cord-015910-d9gxew91	428	10	-	-	HYPH
cord-015910-d9gxew91	428	11	t~	t~	NNP
cord-015910-d9gxew91	428	12	production	production	NN
cord-015910-d9gxew91	428	13	is	be	VBZ
cord-015910-d9gxew91	428	14	at	at	IN
cord-015910-d9gxew91	428	15	first	first	JJ
cord-015910-d9gxew91	428	16	sight	sight	NN
cord-015910-d9gxew91	428	17	paradoxical	paradoxical	JJ
cord-015910-d9gxew91	428	18	,	,	,
cord-015910-d9gxew91	428	19	earlier	early	JJR
cord-015910-d9gxew91	428	20	work	work	NN
cord-015910-d9gxew91	428	21	of	of	IN
cord-015910-d9gxew91	428	22	Dinarello	Dinarello	NNP
cord-015910-d9gxew91	428	23	,	,	,
cord-015910-d9gxew91	428	24	Bishai	Bishai	NNP
cord-015910-d9gxew91	428	25	,	,	,
cord-015910-d9gxew91	428	26	Rosenwasser	Rosenwasser	NNP
cord-015910-d9gxew91	428	27	,	,	,
cord-015910-d9gxew91	428	28	and	and	CC
cord-015910-d9gxew91	428	29	Coceani	Coceani	NNP
cord-015910-d9gxew91	428	30	(	(	-LRB-
cord-015910-d9gxew91	428	31	1984	1984	CD
cord-015910-d9gxew91	428	32	)	)	-RRB-
cord-015910-d9gxew91	428	33	and	and	CC
cord-015910-d9gxew91	428	34	Kunkel	Kunkel	NNP
cord-015910-d9gxew91	428	35	,	,	,
cord-015910-d9gxew91	428	36	Remick	Remick	NNP
cord-015910-d9gxew91	428	37	,	,	,
cord-015910-d9gxew91	428	38	Spengler	Spengler	NNP
cord-015910-d9gxew91	428	39	,	,	,
cord-015910-d9gxew91	428	40	and	and	CC
cord-015910-d9gxew91	428	41	Chensue	Chensue	NNP
cord-015910-d9gxew91	428	42	(	(	-LRB-
cord-015910-d9gxew91	428	43	1987	1987	CD
cord-015910-d9gxew91	428	44	)	)	-RRB-
cord-015910-d9gxew91	428	45	indicated	indicate	VBD
cord-015910-d9gxew91	428	46	that	that	IN
cord-015910-d9gxew91	428	47	fish	fish	NN
cord-015910-d9gxew91	428	48	oil	oil	NN
cord-015910-d9gxew91	428	49	could	could	MD
cord-015910-d9gxew91	428	50	potentially	potentially	RB
cord-015910-d9gxew91	428	51	change	change	VB
cord-015910-d9gxew91	428	52	cytokine	cytokine	NN
cord-015910-d9gxew91	428	53	production	production	NN
cord-015910-d9gxew91	428	54	in	in	IN
cord-015910-d9gxew91	428	55	either	either	DT
cord-015910-d9gxew91	428	56	direction	direction	NN
cord-015910-d9gxew91	428	57	.	.	.
cord-015910-d9gxew91	429	1	What	what	WDT
cord-015910-d9gxew91	429	2	mechanisms	mechanism	NNS
cord-015910-d9gxew91	429	3	could	could	MD
cord-015910-d9gxew91	429	4	result	result	VB
cord-015910-d9gxew91	429	5	in	in	IN
cord-015910-d9gxew91	429	6	this	this	DT
cord-015910-d9gxew91	429	7	divergent	divergent	JJ
cord-015910-d9gxew91	429	8	effect	effect	NN
cord-015910-d9gxew91	429	9	?	?	.
cord-015910-d9gxew91	430	1	Inflammation	inflammation	NN
cord-015910-d9gxew91	430	2	will	will	MD
cord-015910-d9gxew91	430	3	result	result	VB
cord-015910-d9gxew91	430	4	in	in	IN
cord-015910-d9gxew91	430	5	activation	activation	NN
cord-015910-d9gxew91	430	6	of	of	IN
cord-015910-d9gxew91	430	7	phospholipase	phospholipase	NNP
cord-015910-d9gxew91	430	8	A2	A2	NNP
cord-015910-d9gxew91	430	9	,	,	,
cord-015910-d9gxew91	430	10	which	which	WDT
cord-015910-d9gxew91	430	11	releases	release	VBZ
cord-015910-d9gxew91	430	12	arachidonic	arachidonic	JJ
cord-015910-d9gxew91	430	13	acid	acid	NN
cord-015910-d9gxew91	430	14	(	(	-LRB-
cord-015910-d9gxew91	430	15	AA	aa	NN
cord-015910-d9gxew91	430	16	)	)	-RRB-
cord-015910-d9gxew91	430	17	(	(	-LRB-
cord-015910-d9gxew91	430	18	C20:4	C20:4	NNP
cord-015910-d9gxew91	430	19	n-6	n-6	NNP
cord-015910-d9gxew91	430	20	)	)	-RRB-
cord-015910-d9gxew91	430	21	from	from	IN
cord-015910-d9gxew91	430	22	the	the	DT
cord-015910-d9gxew91	430	23	cell	cell	NN
cord-015910-d9gxew91	430	24	membrane	membrane	NN
cord-015910-d9gxew91	430	25	for	for	IN
cord-015910-d9gxew91	430	26	prostaglandin	prostaglandin	NN
cord-015910-d9gxew91	430	27	E	e	NN
cord-015910-d9gxew91	430	28	2	2	CD
cord-015910-d9gxew91	430	29	(	(	-LRB-
cord-015910-d9gxew91	430	30	PGE2	PGE2	NNP
cord-015910-d9gxew91	430	31	)	)	-RRB-
cord-015910-d9gxew91	430	32	or	or	CC
cord-015910-d9gxew91	430	33	leukotriene	leukotriene	NN
cord-015910-d9gxew91	430	34	B	B	NNP
cord-015910-d9gxew91	430	35	4	4	CD
cord-015910-d9gxew91	430	36	(	(	-LRB-
cord-015910-d9gxew91	430	37	LT	LT	NNP
cord-015910-d9gxew91	430	38	B4	B4	NNP
cord-015910-d9gxew91	430	39	)	)	-RRB-
cord-015910-d9gxew91	430	40	synthesis	synthesis	NN
cord-015910-d9gxew91	430	41	.	.	.
cord-015910-d9gxew91	431	1	The	the	DT
cord-015910-d9gxew91	431	2	in	in	FW
cord-015910-d9gxew91	431	3	vitro	vitro	FW
cord-015910-d9gxew91	431	4	studies	study	NNS
cord-015910-d9gxew91	431	5	(	(	-LRB-
cord-015910-d9gxew91	431	6	Kunkel	Kunkel	NNP
cord-015910-d9gxew91	431	7	et	et	NNP
cord-015910-d9gxew91	431	8	al	al	NNP
cord-015910-d9gxew91	431	9	.	.	NNP
cord-015910-d9gxew91	431	10	,	,	,
cord-015910-d9gxew91	431	11	1987	1987	CD
cord-015910-d9gxew91	431	12	)	)	-RRB-
cord-015910-d9gxew91	431	13	showed	show	VBD
cord-015910-d9gxew91	431	14	that	that	IN
cord-015910-d9gxew91	431	15	PGE2	PGE2	NNP
cord-015910-d9gxew91	431	16	suppressed	suppress	VBD
cord-015910-d9gxew91	431	17	TNF	TNF	NNP
cord-015910-d9gxew91	431	18	-	-	HYPH
cord-015910-d9gxew91	431	19	t~	t~	NNP
cord-015910-d9gxew91	431	20	production	production	NN
cord-015910-d9gxew91	431	21	,	,	,
cord-015910-d9gxew91	431	22	whereas	whereas	IN
cord-015910-d9gxew91	431	23	LTB4	LTB4	NNP
cord-015910-d9gxew91	431	24	had	have	VBD
cord-015910-d9gxew91	431	25	the	the	DT
cord-015910-d9gxew91	431	26	opposite	opposite	JJ
cord-015910-d9gxew91	431	27	effect	effect	NN
cord-015910-d9gxew91	431	28	(	(	-LRB-
cord-015910-d9gxew91	431	29	Dinarello	Dinarello	NNP
cord-015910-d9gxew91	431	30	et	et	FW
cord-015910-d9gxew91	431	31	al	al	NNP
cord-015910-d9gxew91	431	32	.	.	NNP
cord-015910-d9gxew91	431	33	,	,	,
cord-015910-d9gxew91	431	34	1984	1984	CD
cord-015910-d9gxew91	431	35	)	)	-RRB-
cord-015910-d9gxew91	431	36	..	..	.
cord-015910-d9gxew91	432	1	Fish	fish	NN
cord-015910-d9gxew91	432	2	oil	oil	NN
cord-015910-d9gxew91	432	3	is	be	VBZ
cord-015910-d9gxew91	432	4	rich	rich	JJ
cord-015910-d9gxew91	432	5	in	in	IN
cord-015910-d9gxew91	432	6	eicosapentaenoic	eicosapentaenoic	JJ
cord-015910-d9gxew91	432	7	acid	acid	NN
cord-015910-d9gxew91	432	8	(	(	-LRB-
cord-015910-d9gxew91	432	9	C20:5	c20:5	NN
cord-015910-d9gxew91	432	10	n-3	n-3	NN
cord-015910-d9gxew91	432	11	)	)	-RRB-
cord-015910-d9gxew91	432	12	,	,	,
cord-015910-d9gxew91	432	13	which	which	WDT
cord-015910-d9gxew91	432	14	will	will	MD
cord-015910-d9gxew91	432	15	replace	replace	VB
cord-015910-d9gxew91	432	16	AA	AA	NNP
cord-015910-d9gxew91	432	17	in	in	IN
cord-015910-d9gxew91	432	18	the	the	DT
cord-015910-d9gxew91	432	19	cell	cell	NN
cord-015910-d9gxew91	432	20	membrane	membrane	NN
cord-015910-d9gxew91	432	21	and	and	CC
cord-015910-d9gxew91	432	22	results	result	NNS
cord-015910-d9gxew91	432	23	in	in	IN
cord-015910-d9gxew91	432	24	the	the	DT
cord-015910-d9gxew91	432	25	production	production	NN
cord-015910-d9gxew91	432	26	of	of	IN
cord-015910-d9gxew91	432	27	PGE3	PGE3	NNP
cord-015910-d9gxew91	432	28	and	and	CC
cord-015910-d9gxew91	432	29	LT	LT	NNP
cord-015910-d9gxew91	432	30	B5	B5	NNP
cord-015910-d9gxew91	432	31	.	.	.
cord-015910-d9gxew91	433	1	PGE3	PGE3	NNP
cord-015910-d9gxew91	433	2	and	and	CC
cord-015910-d9gxew91	433	3	LT	LT	NNP
cord-015910-d9gxew91	433	4	B5	B5	NNP
cord-015910-d9gxew91	433	5	are	be	VBP
cord-015910-d9gxew91	433	6	considerably	considerably	RB
cord-015910-d9gxew91	433	7	less	less	RBR
cord-015910-d9gxew91	433	8	potent	potent	JJ
cord-015910-d9gxew91	433	9	than	than	IN
cord-015910-d9gxew91	433	10	the	the	DT
cord-015910-d9gxew91	433	11	corresponding	correspond	VBG
cord-015910-d9gxew91	433	12	compounds	compound	NNS
cord-015910-d9gxew91	433	13	produced	produce	VBN
cord-015910-d9gxew91	433	14	from	from	IN
cord-015910-d9gxew91	433	15	AA	AA	NNP
cord-015910-d9gxew91	433	16	,	,	,
cord-015910-d9gxew91	433	17	and	and	CC
cord-015910-d9gxew91	433	18	thus	thus	RB
cord-015910-d9gxew91	433	19	dietary	dietary	JJ
cord-015910-d9gxew91	433	20	fish	fish	NN
cord-015910-d9gxew91	433	21	oil	oil	NN
cord-015910-d9gxew91	433	22	may	may	MD
cord-015910-d9gxew91	433	23	lessen	lessen	VB
cord-015910-d9gxew91	433	24	the	the	DT
cord-015910-d9gxew91	433	25	inhibitory	inhibitory	JJ
cord-015910-d9gxew91	433	26	influence	influence	NN
cord-015910-d9gxew91	433	27	of	of	IN
cord-015910-d9gxew91	433	28	PGE2	PGE2	NNP
cord-015910-d9gxew91	433	29	or	or	CC
cord-015910-d9gxew91	433	30	the	the	DT
cord-015910-d9gxew91	433	31	stimulatory	stimulatory	JJ
cord-015910-d9gxew91	433	32	influence	influence	NN
cord-015910-d9gxew91	433	33	of	of	IN
cord-015910-d9gxew91	433	34	LTB4	LTB4	NNP
cord-015910-d9gxew91	433	35	on	on	IN
cord-015910-d9gxew91	433	36	TNF	TNF	NNP
cord-015910-d9gxew91	433	37	-	-	HYPH
cord-015910-d9gxew91	433	38	o~	o~	CD
cord-015910-d9gxew91	433	39	production	production	NN
cord-015910-d9gxew91	433	40	,	,	,
cord-015910-d9gxew91	433	41	resulting	result	VBG
cord-015910-d9gxew91	433	42	in	in	IN
cord-015910-d9gxew91	433	43	a	a	DT
cord-015910-d9gxew91	433	44	potential	potential	JJ
cord-015910-d9gxew91	433	45	increase	increase	NN
cord-015910-d9gxew91	433	46	or	or	CC
cord-015910-d9gxew91	433	47	decrease	decrease	NN
cord-015910-d9gxew91	433	48	,	,	,
cord-015910-d9gxew91	433	49	respectively	respectively	RB
cord-015910-d9gxew91	433	50	,	,	,
cord-015910-d9gxew91	433	51	in	in	IN
cord-015910-d9gxew91	433	52	production	production	NN
cord-015910-d9gxew91	433	53	of	of	IN
cord-015910-d9gxew91	433	54	the	the	DT
cord-015910-d9gxew91	433	55	cytokine	cytokine	NN
cord-015910-d9gxew91	433	56	.	.	.
cord-015910-d9gxew91	434	1	Fish	fish	NN
cord-015910-d9gxew91	434	2	oil	oil	NN
cord-015910-d9gxew91	434	3	could	could	MD
cord-015910-d9gxew91	434	4	thus	thus	RB
cord-015910-d9gxew91	434	5	result	result	VB
cord-015910-d9gxew91	434	6	in	in	IN
cord-015910-d9gxew91	434	7	an	an	DT
cord-015910-d9gxew91	434	8	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	434	9	cytokine	cytokine	NN
cord-015910-d9gxew91	434	10	response	response	NN
cord-015910-d9gxew91	434	11	,	,	,
cord-015910-d9gxew91	434	12	which	which	WDT
cord-015910-d9gxew91	434	13	could	could	MD
cord-015910-d9gxew91	434	14	fall	fall	VB
cord-015910-d9gxew91	434	15	on	on	IN
cord-015910-d9gxew91	434	16	either	either	DT
cord-015910-d9gxew91	434	17	side	side	NN
cord-015910-d9gxew91	434	18	of	of	IN
cord-015910-d9gxew91	434	19	the	the	DT
cord-015910-d9gxew91	434	20	pivot	pivot	NN
cord-015910-d9gxew91	434	21	.	.	.
cord-015910-d9gxew91	435	1	The	the	DT
cord-015910-d9gxew91	435	2	response	response	NN
cord-015910-d9gxew91	435	3	to	to	IN
cord-015910-d9gxew91	435	4	bacterial	bacterial	JJ
cord-015910-d9gxew91	435	5	invasion	invasion	NN
cord-015910-d9gxew91	435	6	of	of	IN
cord-015910-d9gxew91	435	7	the	the	DT
cord-015910-d9gxew91	435	8	body	body	NN
cord-015910-d9gxew91	435	9	,	,	,
cord-015910-d9gxew91	435	10	or	or	CC
cord-015910-d9gxew91	435	11	injury	injury	NN
cord-015910-d9gxew91	435	12	,	,	,
cord-015910-d9gxew91	435	13	contains	contain	VBZ
cord-015910-d9gxew91	435	14	a	a	DT
cord-015910-d9gxew91	435	15	paradox	paradox	NN
cord-015910-d9gxew91	435	16	.	.	.
cord-015910-d9gxew91	436	1	Although	although	IN
cord-015910-d9gxew91	436	2	the	the	DT
cord-015910-d9gxew91	436	3	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	436	4	response	response	NN
cord-015910-d9gxew91	436	5	and	and	CC
cord-015910-d9gxew91	436	6	the	the	DT
cord-015910-d9gxew91	436	7	T	t	NN
cord-015910-d9gxew91	436	8	-	-	HYPH
cord-015910-d9gxew91	436	9	cell	cell	NN
cord-015910-d9gxew91	436	10	response	response	NN
cord-015910-d9gxew91	436	11	both	both	DT
cord-015910-d9gxew91	436	12	play	play	VBP
cord-015910-d9gxew91	436	13	a	a	DT
cord-015910-d9gxew91	436	14	part	part	NN
cord-015910-d9gxew91	436	15	in	in	IN
cord-015910-d9gxew91	436	16	defeating	defeat	VBG
cord-015910-d9gxew91	436	17	the	the	DT
cord-015910-d9gxew91	436	18	invader	invader	NN
cord-015910-d9gxew91	436	19	,	,	,
cord-015910-d9gxew91	436	20	the	the	DT
cord-015910-d9gxew91	436	21	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	436	22	response	response	NN
cord-015910-d9gxew91	436	23	may	may	MD
cord-015910-d9gxew91	436	24	in	in	IN
cord-015910-d9gxew91	436	25	some	some	DT
cord-015910-d9gxew91	436	26	clinical	clinical	JJ
cord-015910-d9gxew91	436	27	circumstances	circumstance	NNS
cord-015910-d9gxew91	436	28	exert	exert	VBP
cord-015910-d9gxew91	436	29	an	an	DT
cord-015910-d9gxew91	436	30	inhibitory	inhibitory	JJ
cord-015910-d9gxew91	436	31	influence	influence	NN
cord-015910-d9gxew91	436	32	on	on	IN
cord-015910-d9gxew91	436	33	T	t	NN
cord-015910-d9gxew91	436	34	-	-	HYPH
cord-015910-d9gxew91	436	35	cell	cell	NN
cord-015910-d9gxew91	436	36	function	function	NN
cord-015910-d9gxew91	436	37	.	.	.
cord-015910-d9gxew91	437	1	In	in	IN
cord-015910-d9gxew91	437	2	severely	severely	RB
cord-015910-d9gxew91	437	3	infected	infect	VBN
cord-015910-d9gxew91	437	4	or	or	CC
cord-015910-d9gxew91	437	5	traumatized	traumatize	VBN
cord-015910-d9gxew91	437	6	patients	patient	NNS
cord-015910-d9gxew91	437	7	,	,	,
cord-015910-d9gxew91	437	8	an	an	DT
cord-015910-d9gxew91	437	9	enhanced	enhance	VBN
cord-015910-d9gxew91	437	10	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	437	11	state	state	NN
cord-015910-d9gxew91	437	12	occurs	occur	VBZ
cord-015910-d9gxew91	437	13	,	,	,
cord-015910-d9gxew91	437	14	which	which	WDT
cord-015910-d9gxew91	437	15	is	be	VBZ
cord-015910-d9gxew91	437	16	associated	associate	VBN
cord-015910-d9gxew91	437	17	with	with	IN
cord-015910-d9gxew91	437	18	immunosuppression	immunosuppression	NN
cord-015910-d9gxew91	437	19	.	.	.
cord-015910-d9gxew91	438	1	In	in	IN
cord-015910-d9gxew91	438	2	vitro	vitro	FW
cord-015910-d9gxew91	438	3	studies	study	NNS
cord-015910-d9gxew91	438	4	support	support	VBP
cord-015910-d9gxew91	438	5	this	this	DT
cord-015910-d9gxew91	438	6	inverse	inverse	JJ
cord-015910-d9gxew91	438	7	relationship	relationship	NN
cord-015910-d9gxew91	438	8	.	.	.
cord-015910-d9gxew91	439	1	PBMCs	pbmc	NNS
cord-015910-d9gxew91	439	2	taken	take	VBN
cord-015910-d9gxew91	439	3	from	from	IN
cord-015910-d9gxew91	439	4	healthy	healthy	JJ
cord-015910-d9gxew91	439	5	young	young	JJ
cord-015910-d9gxew91	439	6	subjects	subject	NNS
cord-015910-d9gxew91	439	7	and	and	CC
cord-015910-d9gxew91	439	8	incubated	incubate	VBN
cord-015910-d9gxew91	439	9	with	with	IN
cord-015910-d9gxew91	439	10	GSH	GSH	NNP
cord-015910-d9gxew91	439	11	show	show	NN
cord-015910-d9gxew91	439	12	decreased	decrease	VBD
cord-015910-d9gxew91	440	1	PGE2	PGE2	NNP
cord-015910-d9gxew91	440	2	and	and	CC
cord-015910-d9gxew91	440	3	LTB4	LTB4	NNP
cord-015910-d9gxew91	440	4	production	production	NN
cord-015910-d9gxew91	440	5	(	(	-LRB-
cord-015910-d9gxew91	440	6	reduced	reduce	VBN
cord-015910-d9gxew91	440	7	inflammation	inflammation	NN
cord-015910-d9gxew91	440	8	)	)	-RRB-
cord-015910-d9gxew91	440	9	and	and	CC
cord-015910-d9gxew91	440	10	an	an	DT
cord-015910-d9gxew91	440	11	increase	increase	NN
cord-015910-d9gxew91	440	12	in	in	IN
cord-015910-d9gxew91	440	13	mitogenic	mitogenic	NNP
cord-015910-d9gxew91	440	14	index	index	NN
cord-015910-d9gxew91	440	15	and	and	CC
cord-015910-d9gxew91	440	16	IL-2	IL-2	NNP
cord-015910-d9gxew91	440	17	production	production	NN
cord-015910-d9gxew91	440	18	(	(	-LRB-
cord-015910-d9gxew91	440	19	enhanced	enhance	VBN
cord-015910-d9gxew91	440	20	immune	immune	JJ
cord-015910-d9gxew91	440	21	function	function	NN
cord-015910-d9gxew91	440	22	)	)	-RRB-
cord-015910-d9gxew91	441	1	(	(	-LRB-
cord-015910-d9gxew91	441	2	Wu	Wu	NNP
cord-015910-d9gxew91	441	3	,	,	,
cord-015910-d9gxew91	441	4	Meydani	Meydani	NNP
cord-015910-d9gxew91	441	5	,	,	,
cord-015910-d9gxew91	441	6	Sastre	Sastre	NNP
cord-015910-d9gxew91	441	7	,	,	,
cord-015910-d9gxew91	441	8	Hayek	Hayek	NNP
cord-015910-d9gxew91	441	9	,	,	,
cord-015910-d9gxew91	441	10	&	&	CC
cord-015910-d9gxew91	441	11	Meydani	Meydani	NNP
cord-015910-d9gxew91	441	12	,	,	,
cord-015910-d9gxew91	441	13	1994	1994	CD
cord-015910-d9gxew91	441	14	)	)	-RRB-
cord-015910-d9gxew91	441	15	.	.	.
cord-015910-d9gxew91	442	1	Thus	thus	RB
cord-015910-d9gxew91	442	2	,	,	,
cord-015910-d9gxew91	442	3	enhancement	enhancement	NN
cord-015910-d9gxew91	442	4	of	of	IN
cord-015910-d9gxew91	442	5	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	442	6	defenses	defense	NNS
cord-015910-d9gxew91	442	7	reduces	reduce	VBZ
cord-015910-d9gxew91	442	8	the	the	DT
cord-015910-d9gxew91	442	9	likelihood	likelihood	NN
cord-015910-d9gxew91	442	10	of	of	IN
cord-015910-d9gxew91	442	11	the	the	DT
cord-015910-d9gxew91	442	12	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	442	13	response	response	NN
cord-015910-d9gxew91	442	14	suppressing	suppress	VBG
cord-015910-d9gxew91	442	15	T	t	NN
cord-015910-d9gxew91	442	16	-	-	HYPH
cord-015910-d9gxew91	442	17	cell	cell	NN
cord-015910-d9gxew91	442	18	function	function	NN
cord-015910-d9gxew91	442	19	(	(	-LRB-
cord-015910-d9gxew91	442	20	Grimble	Grimble	NNP
cord-015910-d9gxew91	442	21	,	,	,
cord-015910-d9gxew91	442	22	1997	1997	CD
cord-015910-d9gxew91	442	23	(	(	-LRB-
cord-015910-d9gxew91	442	24	Grimble	Grimble	NNP
cord-015910-d9gxew91	442	25	,	,	,
cord-015910-d9gxew91	442	26	,	,	,
cord-015910-d9gxew91	442	27	2001b	2001b	CD
cord-015910-d9gxew91	442	28	.	.	.
cord-015910-d9gxew91	443	1	Although	although	IN
cord-015910-d9gxew91	443	2	all	all	DT
cord-015910-d9gxew91	443	3	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	443	4	are	be	VBP
cord-015910-d9gxew91	443	5	important	important	JJ
cord-015910-d9gxew91	443	6	owing	owing	NN
cord-015910-d9gxew91	443	7	to	to	IN
cord-015910-d9gxew91	443	8	the	the	DT
cord-015910-d9gxew91	443	9	linked	link	VBN
cord-015910-d9gxew91	443	10	nature	nature	NN
cord-015910-d9gxew91	443	11	of	of	IN
cord-015910-d9gxew91	443	12	antioxidant	antioxidant	NN
cord-015910-d9gxew91	443	13	defense	defense	NN
cord-015910-d9gxew91	443	14	(	(	-LRB-
cord-015910-d9gxew91	443	15	Fig	Fig	NNP
cord-015910-d9gxew91	443	16	.	.	.
cord-015910-d9gxew91	443	17	8)	8)	NNP
cord-015910-d9gxew91	443	18	,	,	,
cord-015910-d9gxew91	443	19	GSH	GSH	NNP
cord-015910-d9gxew91	443	20	plays	play	VBZ
cord-015910-d9gxew91	443	21	a	a	DT
cord-015910-d9gxew91	443	22	pivotal	pivotal	JJ
cord-015910-d9gxew91	443	23	role	role	NN
cord-015910-d9gxew91	443	24	as	as	IN
cord-015910-d9gxew91	443	25	it	-PRON-	PRP
cord-015910-d9gxew91	443	26	acts	act	VBZ
cord-015910-d9gxew91	443	27	directly	directly	RB
cord-015910-d9gxew91	443	28	as	as	IN
cord-015910-d9gxew91	443	29	an	an	DT
cord-015910-d9gxew91	443	30	antioxidant	antioxidant	NN
cord-015910-d9gxew91	443	31	and	and	CC
cord-015910-d9gxew91	443	32	maintains	maintain	VBZ
cord-015910-d9gxew91	443	33	other	other	JJ
cord-015910-d9gxew91	443	34	components	component	NNS
cord-015910-d9gxew91	443	35	of	of	IN
cord-015910-d9gxew91	443	36	defense	defense	NN
cord-015910-d9gxew91	443	37	in	in	IN
cord-015910-d9gxew91	443	38	a	a	DT
cord-015910-d9gxew91	443	39	reduced	reduce	VBN
cord-015910-d9gxew91	443	40	state	state	NN
cord-015910-d9gxew91	443	41	through	through	IN
cord-015910-d9gxew91	443	42	enzymic	enzymic	NNP
cord-015910-d9gxew91	443	43	conversion	conversion	NN
cord-015910-d9gxew91	443	44	between	between	IN
cord-015910-d9gxew91	443	45	the	the	DT
cord-015910-d9gxew91	443	46	oxidized	oxidize	VBN
cord-015910-d9gxew91	443	47	and	and	CC
cord-015910-d9gxew91	443	48	reduced	reduce	VBN
cord-015910-d9gxew91	443	49	states	state	NNS
cord-015910-d9gxew91	443	50	.	.	.
cord-015910-d9gxew91	444	1	Various	various	JJ
cord-015910-d9gxew91	444	2	compounds	compound	NNS
cord-015910-d9gxew91	444	3	can	can	MD
cord-015910-d9gxew91	444	4	be	be	VB
cord-015910-d9gxew91	444	5	used	use	VBN
cord-015910-d9gxew91	444	6	to	to	TO
cord-015910-d9gxew91	444	7	increase	increase	VB
cord-015910-d9gxew91	444	8	GSH	GSH	NNP
cord-015910-d9gxew91	444	9	synthesis	synthesis	NN
cord-015910-d9gxew91	444	10	(	(	-LRB-
cord-015910-d9gxew91	444	11	Fig	fig	NN
cord-015910-d9gxew91	444	12	.	.	.
cord-015910-d9gxew91	444	13	9	9	CD
cord-015910-d9gxew91	444	14	)	)	-RRB-
cord-015910-d9gxew91	444	15	.	.	.
cord-015910-d9gxew91	445	1	N	n	CD
cord-015910-d9gxew91	445	2	-	-	HYPH
cord-015910-d9gxew91	445	3	Acetyl	Acetyl	NNP
cord-015910-d9gxew91	445	4	cysteine	cysteine	NN
cord-015910-d9gxew91	445	5	(	(	-LRB-
cord-015910-d9gxew91	445	6	NAC	NAC	NNP
cord-015910-d9gxew91	445	7	)	)	-RRB-
cord-015910-d9gxew91	445	8	and	and	CC
cord-015910-d9gxew91	445	9	the	the	DT
cord-015910-d9gxew91	445	10	GSH	GSH	NNP
cord-015910-d9gxew91	445	11	prodrug	prodrug	NN
cord-015910-d9gxew91	445	12	oxothiazalidine-4-carboxylate	oxothiazalidine-4-carboxylate	NNP
cord-015910-d9gxew91	445	13	(	(	-LRB-
cord-015910-d9gxew91	445	14	procysteine	procysteine	NNP
cord-015910-d9gxew91	445	15	)	)	-RRB-
cord-015910-d9gxew91	445	16	have	have	VBP
cord-015910-d9gxew91	445	17	been	be	VBN
cord-015910-d9gxew91	445	18	used	use	VBN
cord-015910-d9gxew91	445	19	in	in	IN
cord-015910-d9gxew91	445	20	a	a	DT
cord-015910-d9gxew91	445	21	number	number	NN
cord-015910-d9gxew91	445	22	of	of	IN
cord-015910-d9gxew91	445	23	clinical	clinical	JJ
cord-015910-d9gxew91	445	24	studies	study	NNS
cord-015910-d9gxew91	445	25	.	.	.
cord-015910-d9gxew91	446	1	Tissue	tissue	NN
cord-015910-d9gxew91	446	2	GSH	GSH	NNP
cord-015910-d9gxew91	446	3	content	content	NN
cord-015910-d9gxew91	446	4	is	be	VBZ
cord-015910-d9gxew91	446	5	also	also	RB
cord-015910-d9gxew91	446	6	influenced	influence	VBN
cord-015910-d9gxew91	446	7	by	by	IN
cord-015910-d9gxew91	446	8	protein	protein	NN
cord-015910-d9gxew91	446	9	and	and	CC
cord-015910-d9gxew91	446	10	sulfur	sulfur	NN
cord-015910-d9gxew91	446	11	amino	amino	NN
cord-015910-d9gxew91	446	12	acid	acid	NN
cord-015910-d9gxew91	446	13	intake	intake	NN
cord-015910-d9gxew91	446	14	.	.	.
cord-015910-d9gxew91	447	1	Unfortunately	unfortunately	RB
cord-015910-d9gxew91	447	2	,	,	,
cord-015910-d9gxew91	447	3	surgery	surgery	NN
cord-015910-d9gxew91	447	4	,	,	,
cord-015910-d9gxew91	447	5	a	a	DT
cord-015910-d9gxew91	447	6	wide	wide	JJ
cord-015910-d9gxew91	447	7	range	range	NN
cord-015910-d9gxew91	447	8	of	of	IN
cord-015910-d9gxew91	447	9	diseases	disease	NNS
cord-015910-d9gxew91	447	10	that	that	WDT
cord-015910-d9gxew91	447	11	have	have	VBP
cord-015910-d9gxew91	447	12	an	an	DT
cord-015910-d9gxew91	447	13	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	447	14	component	component	NN
cord-015910-d9gxew91	447	15	,	,	,
cord-015910-d9gxew91	447	16	and	and	CC
cord-015910-d9gxew91	447	17	aging	age	VBG
cord-015910-d9gxew91	447	18	and	and	CC
cord-015910-d9gxew91	447	19	protein	protein	NN
cord-015910-d9gxew91	447	20	energy	energy	NN
cord-015910-d9gxew91	447	21	malnutrition	malnutrition	NN
cord-015910-d9gxew91	447	22	decrease	decrease	VBP
cord-015910-d9gxew91	447	23	GSH	GSH	NNP
cord-015910-d9gxew91	447	24	concentration	concentration	NN
cord-015910-d9gxew91	447	25	in	in	IN
cord-015910-d9gxew91	447	26	blood	blood	NN
cord-015910-d9gxew91	447	27	and	and	CC
cord-015910-d9gxew91	447	28	other	other	JJ
cord-015910-d9gxew91	447	29	tissues	tissue	NNS
cord-015910-d9gxew91	448	1	(	(	-LRB-
cord-015910-d9gxew91	448	2	Boya	Boya	NNP
cord-015910-d9gxew91	448	3	et	et	NNP
cord-015910-d9gxew91	448	4	al	al	NNP
cord-015910-d9gxew91	448	5	.	.	NNP
cord-015910-d9gxew91	448	6	,	,	,
cord-015910-d9gxew91	448	7	1999	1999	CD
cord-015910-d9gxew91	449	1	;	;	:
cord-015910-d9gxew91	449	2	Loguercio	Loguercio	NNP
cord-015910-d9gxew91	449	3	et	et	NNP
cord-015910-d9gxew91	449	4	al	al	NNP
cord-015910-d9gxew91	449	5	.	.	NNP
cord-015910-d9gxew91	449	6	,	,	,
cord-015910-d9gxew91	449	7	1999	1999	CD
cord-015910-d9gxew91	449	8	;	;	:
cord-015910-d9gxew91	449	9	Luo	Luo	NNP
cord-015910-d9gxew91	449	10	,	,	,
cord-015910-d9gxew91	449	11	Hammarqvist	Hammarqvist	NNP
cord-015910-d9gxew91	449	12	,	,	,
cord-015910-d9gxew91	449	13	Anderson	Anderson	NNP
cord-015910-d9gxew91	449	14	,	,	,
cord-015910-d9gxew91	449	15	&	&	CC
cord-015910-d9gxew91	449	16	Wernerman	Wernerman	NNP
cord-015910-d9gxew91	449	17	,	,	,
cord-015910-d9gxew91	449	18	1996	1996	CD
cord-015910-d9gxew91	449	19	;	;	:
cord-015910-d9gxew91	449	20	Micke	Micke	NNP
cord-015910-d9gxew91	449	21	,	,	,
cord-015910-d9gxew91	449	22	Beeh	Beeh	NNP
cord-015910-d9gxew91	449	23	,	,	,
cord-015910-d9gxew91	449	24	Schlaak	Schlaak	NNP
cord-015910-d9gxew91	449	25	,	,	,
cord-015910-d9gxew91	449	26	&	&	CC
cord-015910-d9gxew91	449	27	Buhl	Buhl	NNP
cord-015910-d9gxew91	449	28	,	,	,
cord-015910-d9gxew91	449	29	2001	2001	CD
cord-015910-d9gxew91	449	30	;	;	:
cord-015910-d9gxew91	449	31	Nuttal	Nuttal	NNP
cord-015910-d9gxew91	449	32	et	et	FW
cord-015910-d9gxew91	449	33	al	al	NNP
cord-015910-d9gxew91	449	34	.	.	NNP
cord-015910-d9gxew91	449	35	,	,	,
cord-015910-d9gxew91	449	36	1999	1999	CD
cord-015910-d9gxew91	449	37	;	;	:
cord-015910-d9gxew91	449	38	Reid	Reid	NNP
cord-015910-d9gxew91	449	39	et	et	NNP
cord-015910-d9gxew91	449	40	al	al	NNP
cord-015910-d9gxew91	449	41	.	.	NNP
cord-015910-d9gxew91	449	42	,	,	,
cord-015910-d9gxew91	449	43	2000	2000	CD
cord-015910-d9gxew91	449	44	)	)	-RRB-
cord-015910-d9gxew91	449	45	(	(	-LRB-
cord-015910-d9gxew91	449	46	Table	table	NN
cord-015910-d9gxew91	449	47	5	5	CD
cord-015910-d9gxew91	449	48	)	)	-RRB-
cord-015910-d9gxew91	449	49	.	.	.
cord-015910-d9gxew91	450	1	Within	within	IN
cord-015910-d9gxew91	450	2	24	24	CD
cord-015910-d9gxew91	450	3	h	h	NN
cord-015910-d9gxew91	450	4	of	of	IN
cord-015910-d9gxew91	450	5	elective	elective	JJ
cord-015910-d9gxew91	450	6	abdominal	abdominal	JJ
cord-015910-d9gxew91	450	7	surgery	surgery	NN
cord-015910-d9gxew91	450	8	,	,	,
cord-015910-d9gxew91	450	9	muscle	muscle	NN
cord-015910-d9gxew91	450	10	GSH	GSH	NNP
cord-015910-d9gxew91	450	11	content	content	NN
cord-015910-d9gxew91	450	12	falls	fall	VBZ
cord-015910-d9gxew91	450	13	by	by	IN
cord-015910-d9gxew91	450	14	>	>	$
cord-015910-d9gxew91	450	15	30	30	CD
cord-015910-d9gxew91	450	16	%	%	NN
cord-015910-d9gxew91	450	17	.	.	.
cord-015910-d9gxew91	451	1	Values	value	NNS
cord-015910-d9gxew91	451	2	return	return	VBP
cord-015910-d9gxew91	451	3	to	to	IN
cord-015910-d9gxew91	451	4	normal	normal	JJ
cord-015910-d9gxew91	451	5	72	72	CD
cord-015910-d9gxew91	451	6	h	h	NN
cord-015910-d9gxew91	451	7	postoperatively	postoperatively	NN
cord-015910-d9gxew91	451	8	.	.	.
cord-015910-d9gxew91	452	1	A	a	DT
cord-015910-d9gxew91	452	2	smaller	small	JJR
cord-015910-d9gxew91	452	3	perturbation	perturbation	NN
cord-015910-d9gxew91	452	4	in	in	IN
cord-015910-d9gxew91	452	5	blood	blood	NN
cord-015910-d9gxew91	452	6	GSH	GSH	NNP
cord-015910-d9gxew91	452	7	occurs	occur	VBZ
cord-015910-d9gxew91	452	8	over	over	IN
cord-015910-d9gxew91	452	9	a	a	DT
cord-015910-d9gxew91	452	10	shorter	short	JJR
cord-015910-d9gxew91	452	11	time	time	NN
cord-015910-d9gxew91	452	12	course	course	NN
cord-015910-d9gxew91	452	13	.	.	.
cord-015910-d9gxew91	453	1	Modification	modification	NN
cord-015910-d9gxew91	453	2	of	of	IN
cord-015910-d9gxew91	453	3	the	the	DT
cord-015910-d9gxew91	453	4	GSH	GSH	NNP
cord-015910-d9gxew91	453	5	content	content	NN
cord-015910-d9gxew91	453	6	of	of	IN
cord-015910-d9gxew91	453	7	liver	liver	NN
cord-015910-d9gxew91	453	8	,	,	,
cord-015910-d9gxew91	453	9	lung	lung	NN
cord-015910-d9gxew91	453	10	,	,	,
cord-015910-d9gxew91	453	11	spleen	spleen	NNS
cord-015910-d9gxew91	453	12	,	,	,
cord-015910-d9gxew91	453	13	and	and	CC
cord-015910-d9gxew91	453	14	thymus	thymus	NN
cord-015910-d9gxew91	453	15	in	in	IN
cord-015910-d9gxew91	453	16	young	young	JJ
cord-015910-d9gxew91	453	17	rats	rat	NNS
cord-015910-d9gxew91	453	18	by	by	IN
cord-015910-d9gxew91	453	19	feeding	feed	VBG
cord-015910-d9gxew91	453	20	diets	diet	NNS
cord-015910-d9gxew91	453	21	containing	contain	VBG
cord-015910-d9gxew91	453	22	a	a	DT
cord-015910-d9gxew91	453	23	range	range	NN
cord-015910-d9gxew91	453	24	of	of	IN
cord-015910-d9gxew91	453	25	casein	casein	NN
cord-015910-d9gxew91	453	26	(	(	-LRB-
cord-015910-d9gxew91	453	27	a	a	DT
cord-015910-d9gxew91	453	28	protein	protein	NN
cord-015910-d9gxew91	453	29	with	with	IN
cord-015910-d9gxew91	453	30	a	a	DT
cord-015910-d9gxew91	453	31	low	low	JJ
cord-015910-d9gxew91	453	32	sulfur	sulfur	NN
cord-015910-d9gxew91	453	33	amino	amino	NN
cord-015910-d9gxew91	453	34	acid	acid	NN
cord-015910-d9gxew91	453	35	content	content	NN
cord-015910-d9gxew91	453	36	)	)	-RRB-
cord-015910-d9gxew91	453	37	concentrations	concentration	NNS
cord-015910-d9gxew91	453	38	changed	change	VBD
cord-015910-d9gxew91	453	39	immune	immune	JJ
cord-015910-d9gxew91	453	40	cell	cell	NN
cord-015910-d9gxew91	453	41	numbers	number	NNS
cord-015910-d9gxew91	453	42	in	in	IN
cord-015910-d9gxew91	453	43	lung	lung	NN
cord-015910-d9gxew91	453	44	(	(	-LRB-
cord-015910-d9gxew91	453	45	Hunter	Hunter	NNP
cord-015910-d9gxew91	453	46	&	&	CC
cord-015910-d9gxew91	453	47	Grimble	Grimble	NNP
cord-015910-d9gxew91	453	48	,	,	,
cord-015910-d9gxew91	453	49	1994	1994	CD
cord-015910-d9gxew91	453	50	found	find	VBD
cord-015910-d9gxew91	453	51	that	that	IN
cord-015910-d9gxew91	453	52	in	in	IN
cord-015910-d9gxew91	453	53	unstressed	unstressed	JJ
cord-015910-d9gxew91	453	54	animals	animal	NNS
cord-015910-d9gxew91	453	55	the	the	DT
cord-015910-d9gxew91	453	56	number	number	NN
cord-015910-d9gxew91	453	57	of	of	IN
cord-015910-d9gxew91	453	58	lung	lung	NN
cord-015910-d9gxew91	453	59	neutrophils	neutrophil	NNS
cord-015910-d9gxew91	453	60	decreased	decrease	VBD
cord-015910-d9gxew91	453	61	as	as	IN
cord-015910-d9gxew91	453	62	dietary	dietary	JJ
cord-015910-d9gxew91	453	63	protein	protein	NN
cord-015910-d9gxew91	453	64	intake	intake	NN
cord-015910-d9gxew91	453	65	and	and	CC
cord-015910-d9gxew91	453	66	tissue	tissue	NN
cord-015910-d9gxew91	453	67	GSH	GSH	NNP
cord-015910-d9gxew91	453	68	content	content	NN
cord-015910-d9gxew91	453	69	fell	fall	VBD
cord-015910-d9gxew91	453	70	.	.	.
cord-015910-d9gxew91	454	1	However	however	RB
cord-015910-d9gxew91	454	2	,	,	,
cord-015910-d9gxew91	454	3	in	in	IN
cord-015910-d9gxew91	454	4	animals	animal	NNS
cord-015910-d9gxew91	454	5	given	give	VBN
cord-015910-d9gxew91	454	6	an	an	DT
cord-015910-d9gxew91	454	7	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	454	8	challenge	challenge	NN
cord-015910-d9gxew91	454	9	(	(	-LRB-
cord-015910-d9gxew91	454	10	endotoxin	endotoxin	NN
cord-015910-d9gxew91	454	11	)	)	-RRB-
cord-015910-d9gxew91	454	12	,	,	,
cord-015910-d9gxew91	454	13	liver	liver	NN
cord-015910-d9gxew91	454	14	and	and	CC
cord-015910-d9gxew91	454	15	lung	lung	NN
cord-015910-d9gxew91	454	16	GSH	GSH	NNP
cord-015910-d9gxew91	454	17	concentrations	concentration	NNS
cord-015910-d9gxew91	454	18	increased	increase	VBD
cord-015910-d9gxew91	454	19	directly	directly	RB
cord-015910-d9gxew91	454	20	in	in	IN
cord-015910-d9gxew91	454	21	relation	relation	NN
cord-015910-d9gxew91	454	22	to	to	IN
cord-015910-d9gxew91	454	23	dietary	dietary	JJ
cord-015910-d9gxew91	454	24	protein	protein	NN
cord-015910-d9gxew91	454	25	intake	intake	NN
cord-015910-d9gxew91	454	26	.	.	.
cord-015910-d9gxew91	455	1	Lung	lung	NN
cord-015910-d9gxew91	455	2	neutrophils	neutrophil	NNS
cord-015910-d9gxew91	455	3	,	,	,
cord-015910-d9gxew91	455	4	however	however	RB
cord-015910-d9gxew91	455	5	,	,	,
cord-015910-d9gxew91	455	6	became	become	VBD
cord-015910-d9gxew91	455	7	related	related	JJ
cord-015910-d9gxew91	455	8	inversely	inversely	RB
cord-015910-d9gxew91	455	9	with	with	IN
cord-015910-d9gxew91	455	10	tissue	tissue	NN
cord-015910-d9gxew91	455	11	GSH	GSH	NNP
cord-015910-d9gxew91	455	12	content	content	NN
cord-015910-d9gxew91	455	13	.	.	.
cord-015910-d9gxew91	456	1	Addition	addition	NN
cord-015910-d9gxew91	456	2	of	of	IN
cord-015910-d9gxew91	456	3	methionine	methionine	NN
cord-015910-d9gxew91	456	4	to	to	IN
cord-015910-d9gxew91	456	5	the	the	DT
cord-015910-d9gxew91	456	6	protein	protein	NN
cord-015910-d9gxew91	456	7	-	-	HYPH
cord-015910-d9gxew91	456	8	deficient	deficient	JJ
cord-015910-d9gxew91	456	9	diets	diet	NNS
cord-015910-d9gxew91	456	10	normalized	normalize	VBD
cord-015910-d9gxew91	456	11	tissue	tissue	NN
cord-015910-d9gxew91	456	12	GSH	GSH	NNP
cord-015910-d9gxew91	456	13	content	content	NN
cord-015910-d9gxew91	456	14	and	and	CC
cord-015910-d9gxew91	456	15	restored	restore	VBD
cord-015910-d9gxew91	456	16	lung	lung	NN
cord-015910-d9gxew91	456	17	neutrophil	neutrophil	NN
cord-015910-d9gxew91	456	18	numbers	number	NNS
cord-015910-d9gxew91	456	19	to	to	IN
cord-015910-d9gxew91	456	20	those	those	DT
cord-015910-d9gxew91	456	21	seen	see	VBN
cord-015910-d9gxew91	456	22	in	in	IN
cord-015910-d9gxew91	456	23	unstressed	unstressed	JJ
cord-015910-d9gxew91	456	24	animals	animal	NNS
cord-015910-d9gxew91	456	25	fed	feed	VBD
cord-015910-d9gxew91	456	26	a	a	DT
cord-015910-d9gxew91	456	27	diet	diet	NN
cord-015910-d9gxew91	456	28	with	with	IN
cord-015910-d9gxew91	456	29	adequate	adequate	JJ
cord-015910-d9gxew91	456	30	protein	protein	NN
cord-015910-d9gxew91	456	31	content	content	NN
cord-015910-d9gxew91	456	32	(	(	-LRB-
cord-015910-d9gxew91	456	33	Fig	Fig	NNP
cord-015910-d9gxew91	456	34	.	.	.
cord-015910-d9gxew91	456	35	10	10	CD
cord-015910-d9gxew91	456	36	)	)	-RRB-
cord-015910-d9gxew91	456	37	.	.	.
cord-015910-d9gxew91	457	1	Why	why	WRB
cord-015910-d9gxew91	457	2	does	do	VBZ
cord-015910-d9gxew91	457	3	tissue	tissue	VB
cord-015910-d9gxew91	457	4	GSH	GSH	NNP
cord-015910-d9gxew91	457	5	content	content	NN
cord-015910-d9gxew91	457	6	have	have	VBP
cord-015910-d9gxew91	457	7	differing	differ	VBG
cord-015910-d9gxew91	457	8	effects	effect	NNS
cord-015910-d9gxew91	457	9	on	on	IN
cord-015910-d9gxew91	457	10	immune	immune	JJ
cord-015910-d9gxew91	457	11	cell	cell	NN
cord-015910-d9gxew91	457	12	populations	population	NNS
cord-015910-d9gxew91	457	13	depending	depend	VBG
cord-015910-d9gxew91	457	14	on	on	IN
cord-015910-d9gxew91	457	15	whether	whether	IN
cord-015910-d9gxew91	457	16	or	or	CC
cord-015910-d9gxew91	457	17	not	not	RB
cord-015910-d9gxew91	457	18	an	an	DT
cord-015910-d9gxew91	457	19	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	457	20	response	response	NN
cord-015910-d9gxew91	457	21	is	be	VBZ
cord-015910-d9gxew91	457	22	occurring	occur	VBG
cord-015910-d9gxew91	457	23	?	?	.
cord-015910-d9gxew91	458	1	A	a	DT
cord-015910-d9gxew91	458	2	partial	partial	JJ
cord-015910-d9gxew91	458	3	explanation	explanation	NN
cord-015910-d9gxew91	458	4	may	may	MD
cord-015910-d9gxew91	458	5	come	come	VB
cord-015910-d9gxew91	458	6	from	from	IN
cord-015910-d9gxew91	458	7	an	an	DT
cord-015910-d9gxew91	458	8	in	in	FW
cord-015910-d9gxew91	458	9	vitro	vitro	FW
cord-015910-d9gxew91	458	10	study	study	NN
cord-015910-d9gxew91	458	11	using	use	VBG
cord-015910-d9gxew91	458	12	HeLa	HeLa	NNP
cord-015910-d9gxew91	458	13	cells	cell	NNS
cord-015910-d9gxew91	458	14	and	and	CC
cord-015910-d9gxew91	458	15	cells	cell	NNS
cord-015910-d9gxew91	458	16	from	from	IN
cord-015910-d9gxew91	458	17	human	human	JJ
cord-015910-d9gxew91	458	18	embryonic	embryonic	JJ
cord-015910-d9gxew91	458	19	kidney	kidney	NN
cord-015910-d9gxew91	458	20	.	.	.
cord-015910-d9gxew91	459	1	In	in	IN
cord-015910-d9gxew91	459	2	the	the	DT
cord-015910-d9gxew91	459	3	study	study	NN
cord-015910-d9gxew91	459	4	,	,	,
cord-015910-d9gxew91	459	5	both	both	CC
cord-015910-d9gxew91	459	6	TNF	TNF	NNP
cord-015910-d9gxew91	459	7	-	-	HYPH
cord-015910-d9gxew91	459	8	o~	o~	XX
cord-015910-d9gxew91	459	9	and	and	CC
cord-015910-d9gxew91	459	10	hydrogen	hydrogen	NN
cord-015910-d9gxew91	459	11	peroxide	peroxide	NN
cord-015910-d9gxew91	459	12	resulted	result	VBD
cord-015910-d9gxew91	459	13	in	in	IN
cord-015910-d9gxew91	459	14	activation	activation	NN
cord-015910-d9gxew91	459	15	of	of	IN
cord-015910-d9gxew91	459	16	NF-~cB	nf-~cb	NN
cord-015910-d9gxew91	459	17	and	and	CC
cord-015910-d9gxew91	459	18	AP1	AP1	NNP
cord-015910-d9gxew91	459	19	(	(	-LRB-
cord-015910-d9gxew91	459	20	Wesselborg	Wesselborg	NNP
cord-015910-d9gxew91	459	21	,	,	,
cord-015910-d9gxew91	459	22	Bauer	Bauer	NNP
cord-015910-d9gxew91	459	23	,	,	,
cord-015910-d9gxew91	459	24	Vogt	Vogt	NNP
cord-015910-d9gxew91	459	25	,	,	,
cord-015910-d9gxew91	459	26	Schmitz	Schmitz	NNP
cord-015910-d9gxew91	459	27	,	,	,
cord-015910-d9gxew91	459	28	&	&	CC
cord-015910-d9gxew91	459	29	Schulze	Schulze	NNP
cord-015910-d9gxew91	459	30	-	-	HYPH
cord-015910-d9gxew91	459	31	Osthoff	Osthoff	NNP
cord-015910-d9gxew91	459	32	,	,	,
cord-015910-d9gxew91	459	33	1997	1997	CD
cord-015910-d9gxew91	459	34	)	)	-RRB-
cord-015910-d9gxew91	459	35	.	.	.
cord-015910-d9gxew91	460	1	Addition	addition	NN
cord-015910-d9gxew91	460	2	of	of	IN
cord-015910-d9gxew91	460	3	the	the	DT
cord-015910-d9gxew91	460	4	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	460	5	sorbitol	sorbitol	NN
cord-015910-d9gxew91	460	6	to	to	IN
cord-015910-d9gxew91	460	7	the	the	DT
cord-015910-d9gxew91	460	8	medium	medium	NN
cord-015910-d9gxew91	460	9	suppressed	suppress	VBN
cord-015910-d9gxew91	460	10	NF-~fl3	nf-~fl3	NN
cord-015910-d9gxew91	460	11	activation	activation	NN
cord-015910-d9gxew91	460	12	as	as	IN
cord-015910-d9gxew91	460	13	expected	expect	VBN
cord-015910-d9gxew91	460	14	,	,	,
cord-015910-d9gxew91	460	15	but	but	CC
cord-015910-d9gxew91	460	16	unexpectedly	unexpectedly	RB
cord-015910-d9gxew91	460	17	activated	activate	VBD
cord-015910-d9gxew91	460	18	AP	AP	NNP
cord-015910-d9gxew91	460	19	1	1	CD
cord-015910-d9gxew91	460	20	.	.	.
cord-015910-d9gxew91	461	1	Thus	thus	RB
cord-015910-d9gxew91	461	2	,	,	,
cord-015910-d9gxew91	461	3	the	the	DT
cord-015910-d9gxew91	461	4	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	461	5	environment	environment	NN
cord-015910-d9gxew91	461	6	of	of	IN
cord-015910-d9gxew91	461	7	the	the	DT
cord-015910-d9gxew91	461	8	cell	cell	NN
cord-015910-d9gxew91	461	9	might	may	MD
cord-015910-d9gxew91	461	10	exert	exert	VB
cord-015910-d9gxew91	461	11	opposite	opposite	JJ
cord-015910-d9gxew91	461	12	effects	effect	NNS
cord-015910-d9gxew91	461	13	upon	upon	IN
cord-015910-d9gxew91	461	14	transcription	transcription	NN
cord-015910-d9gxew91	461	15	factors	factor	NNS
cord-015910-d9gxew91	461	16	closely	closely	RB
cord-015910-d9gxew91	461	17	associated	associate	VBN
cord-015910-d9gxew91	461	18	with	with	IN
cord-015910-d9gxew91	461	19	inflammation	inflammation	NN
cord-015910-d9gxew91	461	20	(	(	-LRB-
cord-015910-d9gxew91	461	21	e.g.	e.g.	RB
cord-015910-d9gxew91	461	22	,	,	,
cord-015910-d9gxew91	461	23	NF-~fl3	nf-~fl3	NN
cord-015910-d9gxew91	461	24	)	)	-RRB-
cord-015910-d9gxew91	461	25	and	and	CC
cord-015910-d9gxew91	461	26	cellular	cellular	JJ
cord-015910-d9gxew91	461	27	proliferation	proliferation	NN
cord-015910-d9gxew91	461	28	(	(	-LRB-
cord-015910-d9gxew91	461	29	e.g.	e.g.	RB
cord-015910-d9gxew91	461	30	,	,	,
cord-015910-d9gxew91	461	31	AP1	AP1	NNP
cord-015910-d9gxew91	461	32	)	)	-RRB-
cord-015910-d9gxew91	461	33	.	.	.
cord-015910-d9gxew91	462	1	Evidence	evidence	NN
cord-015910-d9gxew91	462	2	for	for	IN
cord-015910-d9gxew91	462	3	this	this	DT
cord-015910-d9gxew91	462	4	biphasic	biphasic	JJ
cord-015910-d9gxew91	462	5	effect	effect	NN
cord-015910-d9gxew91	462	6	was	be	VBD
cord-015910-d9gxew91	462	7	seen	see	VBN
cord-015910-d9gxew91	462	8	when	when	WRB
cord-015910-d9gxew91	462	9	GSH	GSH	NNP
cord-015910-d9gxew91	462	10	was	be	VBD
cord-015910-d9gxew91	462	11	incubated	incubate	VBN
cord-015910-d9gxew91	462	12	with	with	IN
cord-015910-d9gxew91	462	13	immune	immune	JJ
cord-015910-d9gxew91	462	14	cells	cell	NNS
cord-015910-d9gxew91	462	15	from	from	IN
cord-015910-d9gxew91	462	16	young	young	JJ
cord-015910-d9gxew91	462	17	adults	adult	NNS
cord-015910-d9gxew91	463	1	(	(	-LRB-
cord-015910-d9gxew91	463	2	Wu	Wu	NNP
cord-015910-d9gxew91	463	3	et	et	NNP
cord-015910-d9gxew91	463	4	al	al	NNP
cord-015910-d9gxew91	463	5	.	.	NNP
cord-015910-d9gxew91	463	6	,	,	,
cord-015910-d9gxew91	463	7	1994	1994	CD
cord-015910-d9gxew91	463	8	)	)	-RRB-
cord-015910-d9gxew91	463	9	.	.	.
cord-015910-d9gxew91	464	1	A	a	DT
cord-015910-d9gxew91	464	2	rise	rise	NN
cord-015910-d9gxew91	464	3	in	in	IN
cord-015910-d9gxew91	464	4	cellular	cellular	JJ
cord-015910-d9gxew91	464	5	GSH	GSH	NNP
cord-015910-d9gxew91	464	6	content	content	NN
cord-015910-d9gxew91	464	7	was	be	VBD
cord-015910-d9gxew91	464	8	accompanied	accompany	VBN
cord-015910-d9gxew91	464	9	by	by	IN
cord-015910-d9gxew91	464	10	an	an	DT
cord-015910-d9gxew91	464	11	increase	increase	NN
cord-015910-d9gxew91	464	12	in	in	IN
cord-015910-d9gxew91	464	13	IL-2	il-2	NN
cord-015910-d9gxew91	464	14	production	production	NN
cord-015910-d9gxew91	464	15	and	and	CC
cord-015910-d9gxew91	464	16	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	464	17	proliferation	proliferation	NN
cord-015910-d9gxew91	464	18	(	(	-LRB-
cord-015910-d9gxew91	464	19	enhancement	enhancement	NN
cord-015910-d9gxew91	464	20	of	of	IN
cord-015910-d9gxew91	464	21	T	t	NN
cord-015910-d9gxew91	464	22	-	-	HYPH
cord-015910-d9gxew91	464	23	cell	cell	NN
cord-015910-d9gxew91	464	24	function	function	NN
cord-015910-d9gxew91	464	25	)	)	-RRB-
cord-015910-d9gxew91	464	26	and	and	CC
cord-015910-d9gxew91	464	27	a	a	DT
cord-015910-d9gxew91	464	28	decrease	decrease	NN
cord-015910-d9gxew91	464	29	in	in	IN
cord-015910-d9gxew91	464	30	production	production	NN
cord-015910-d9gxew91	464	31	of	of	IN
cord-015910-d9gxew91	464	32	the	the	DT
cord-015910-d9gxew91	464	33	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	464	34	mediators	mediator	NNS
cord-015910-d9gxew91	464	35	PGE2	PGE2	NNP
cord-015910-d9gxew91	464	36	and	and	CC
cord-015910-d9gxew91	464	37	LTB4	LTB4	NNP
cord-015910-d9gxew91	465	1	(	(	-LRB-
cord-015910-d9gxew91	465	2	anti	anti	JJ
cord-015910-d9gxew91	465	3	-	-	JJ
cord-015910-d9gxew91	465	4	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	465	5	influence	influence	NN
cord-015910-d9gxew91	465	6	)	)	-RRB-
cord-015910-d9gxew91	465	7	.	.	.
cord-015910-d9gxew91	466	1	Without	without	IN
cord-015910-d9gxew91	466	2	doubt	doubt	NN
cord-015910-d9gxew91	466	3	,	,	,
cord-015910-d9gxew91	466	4	a	a	DT
cord-015910-d9gxew91	466	5	decline	decline	NN
cord-015910-d9gxew91	466	6	in	in	IN
cord-015910-d9gxew91	466	7	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	466	8	status	status	NN
cord-015910-d9gxew91	466	9	in	in	IN
cord-015910-d9gxew91	466	10	the	the	DT
cord-015910-d9gxew91	466	11	presence	presence	NN
cord-015910-d9gxew91	466	12	of	of	IN
cord-015910-d9gxew91	466	13	oxidant	oxidant	JJ
cord-015910-d9gxew91	466	14	stress	stress	NN
cord-015910-d9gxew91	466	15	will	will	MD
cord-015910-d9gxew91	466	16	increase	increase	VB
cord-015910-d9gxew91	466	17	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	466	18	stress	stress	NN
cord-015910-d9gxew91	466	19	.	.	.
cord-015910-d9gxew91	467	1	The	the	DT
cord-015910-d9gxew91	467	2	interaction	interaction	NN
cord-015910-d9gxew91	467	3	between	between	IN
cord-015910-d9gxew91	467	4	oxidant	oxidant	JJ
cord-015910-d9gxew91	467	5	stress	stress	NN
cord-015910-d9gxew91	467	6	and	and	CC
cord-015910-d9gxew91	467	7	an	an	DT
cord-015910-d9gxew91	467	8	impaired	impaired	JJ
cord-015910-d9gxew91	467	9	ability	ability	NN
cord-015910-d9gxew91	467	10	to	to	TO
cord-015910-d9gxew91	467	11	synthesize	synthesize	VB
cord-015910-d9gxew91	467	12	GSH	GSH	NNP
cord-015910-d9gxew91	467	13	,	,	,
cord-015910-d9gxew91	467	14	a	a	DT
cord-015910-d9gxew91	467	15	situation	situation	NN
cord-015910-d9gxew91	467	16	that	that	WDT
cord-015910-d9gxew91	467	17	stimulates	stimulate	VBZ
cord-015910-d9gxew91	467	18	inflammation	inflammation	NN
cord-015910-d9gxew91	467	19	,	,	,
cord-015910-d9gxew91	467	20	is	be	VBZ
cord-015910-d9gxew91	467	21	clearly	clearly	RB
cord-015910-d9gxew91	467	22	seen	see	VBN
cord-015910-d9gxew91	467	23	in	in	IN
cord-015910-d9gxew91	467	24	cirrhosis	cirrhosis	NN
cord-015910-d9gxew91	467	25	,	,	,
cord-015910-d9gxew91	467	26	a	a	DT
cord-015910-d9gxew91	467	27	disease	disease	NN
cord-015910-d9gxew91	467	28	that	that	WDT
cord-015910-d9gxew91	467	29	results	result	VBZ
cord-015910-d9gxew91	467	30	in	in	IN
cord-015910-d9gxew91	467	31	high	high	JJ
cord-015910-d9gxew91	467	32	levels	level	NNS
cord-015910-d9gxew91	467	33	of	of	IN
cord-015910-d9gxew91	467	34	oxidative	oxidative	JJ
cord-015910-d9gxew91	467	35	stress	stress	NN
cord-015910-d9gxew91	467	36	and	and	CC
cord-015910-d9gxew91	467	37	an	an	DT
cord-015910-d9gxew91	467	38	impaired	impaired	JJ
cord-015910-d9gxew91	467	39	ability	ability	NN
cord-015910-d9gxew91	467	40	to	to	TO
cord-015910-d9gxew91	467	41	synthesize	synthesize	VB
cord-015910-d9gxew91	467	42	GSH	GSH	NNP
cord-015910-d9gxew91	467	43	.	.	.
cord-015910-d9gxew91	468	1	In	in	IN
cord-015910-d9gxew91	468	2	Pena	Pena	NNP
cord-015910-d9gxew91	468	3	an	an	DT
cord-015910-d9gxew91	468	4	inverse	inverse	JJ
cord-015910-d9gxew91	468	5	relationship	relationship	NN
cord-015910-d9gxew91	468	6	between	between	IN
cord-015910-d9gxew91	468	7	GSH	GSH	NNP
cord-015910-d9gxew91	468	8	concentration	concentration	NN
cord-015910-d9gxew91	468	9	and	and	CC
cord-015910-d9gxew91	468	10	the	the	DT
cord-015910-d9gxew91	468	11	ability	ability	NN
cord-015910-d9gxew91	468	12	of	of	IN
cord-015910-d9gxew91	468	13	monocytes	monocyte	NNS
cord-015910-d9gxew91	468	14	to	to	TO
cord-015910-d9gxew91	468	15	produce	produce	VB
cord-015910-d9gxew91	468	16	IL-1	IL-1	NNP
cord-015910-d9gxew91	468	17	,	,	,
cord-015910-d9gxew91	468	18	IL-8	IL-8	NNP
cord-015910-d9gxew91	468	19	,	,	,
cord-015910-d9gxew91	468	20	and	and	CC
cord-015910-d9gxew91	468	21	TNF	TNF	NNP
cord-015910-d9gxew91	468	22	-	-	HYPH
cord-015910-d9gxew91	468	23	t~	t~	NNP
cord-015910-d9gxew91	468	24	was	be	VBD
cord-015910-d9gxew91	468	25	observed	observe	VBN
cord-015910-d9gxew91	468	26	.	.	.
cord-015910-d9gxew91	469	1	Treatment	treatment	NN
cord-015910-d9gxew91	469	2	of	of	IN
cord-015910-d9gxew91	469	3	cirrhotic	cirrhotic	JJ
cord-015910-d9gxew91	469	4	patients	patient	NNS
cord-015910-d9gxew91	469	5	with	with	IN
cord-015910-d9gxew91	469	6	the	the	DT
cord-015910-d9gxew91	469	7	procysteine	procysteine	NNP
cord-015910-d9gxew91	469	8	increased	increase	VBD
cord-015910-d9gxew91	469	9	monocyte	monocyte	NNP
cord-015910-d9gxew91	469	10	GSH	GSH	NNP
cord-015910-d9gxew91	469	11	content	content	NN
cord-015910-d9gxew91	469	12	and	and	CC
cord-015910-d9gxew91	469	13	reduced	reduce	VBN
cord-015910-d9gxew91	469	14	IL-1	IL-1	NNP
cord-015910-d9gxew91	469	15	,	,	,
cord-015910-d9gxew91	469	16	IL-8	IL-8	NNP
cord-015910-d9gxew91	469	17	,	,	,
cord-015910-d9gxew91	469	18	and	and	CC
cord-015910-d9gxew91	469	19	TNF	TNF	NNP
cord-015910-d9gxew91	469	20	-	-	HYPH
cord-015910-d9gxew91	469	21	t~	t~	NNP
cord-015910-d9gxew91	469	22	production	production	NN
cord-015910-d9gxew91	469	23	.	.	.
cord-015910-d9gxew91	470	1	Septic	septic	JJ
cord-015910-d9gxew91	470	2	patients	patient	NNS
cord-015910-d9gxew91	470	3	given	give	VBD
cord-015910-d9gxew91	470	4	an	an	DT
cord-015910-d9gxew91	470	5	infusion	infusion	NN
cord-015910-d9gxew91	470	6	of	of	IN
cord-015910-d9gxew91	470	7	NAC	NAC	NNP
cord-015910-d9gxew91	470	8	(	(	-LRB-
cord-015910-d9gxew91	470	9	150	150	CD
cord-015910-d9gxew91	470	10	mg	mg	NNP
cord-015910-d9gxew91	470	11	/	/	SYM
cord-015910-d9gxew91	470	12	kg	kg	NN
cord-015910-d9gxew91	470	13	bolus	bolus	NN
cord-015910-d9gxew91	470	14	followed	follow	VBN
cord-015910-d9gxew91	470	15	by	by	IN
cord-015910-d9gxew91	470	16	infusion	infusion	NN
cord-015910-d9gxew91	470	17	of	of	IN
cord-015910-d9gxew91	470	18	50	50	CD
cord-015910-d9gxew91	470	19	mg	mg	NNP
cord-015910-d9gxew91	470	20	/	/	SYM
cord-015910-d9gxew91	470	21	kg	kg	NNP
cord-015910-d9gxew91	470	22	over	over	IN
cord-015910-d9gxew91	470	23	4-h	4-h	CD
cord-015910-d9gxew91	470	24	)	)	-RRB-
cord-015910-d9gxew91	470	25	showed	show	VBD
cord-015910-d9gxew91	470	26	a	a	DT
cord-015910-d9gxew91	470	27	decrease	decrease	NN
cord-015910-d9gxew91	470	28	in	in	IN
cord-015910-d9gxew91	470	29	plasma	plasma	NN
cord-015910-d9gxew91	470	30	IL-8	il-8	NN
cord-015910-d9gxew91	470	31	and	and	CC
cord-015910-d9gxew91	470	32	soluble	soluble	JJ
cord-015910-d9gxew91	470	33	TNF	TNF	NNP
cord-015910-d9gxew91	470	34	receptor	receptor	NN
cord-015910-d9gxew91	470	35	p55	p55	NN
cord-015910-d9gxew91	470	36	,	,	,
cord-015910-d9gxew91	470	37	had	have	VBD
cord-015910-d9gxew91	470	38	a	a	DT
cord-015910-d9gxew91	470	39	reduced	reduce	VBN
cord-015910-d9gxew91	470	40	requirement	requirement	NN
cord-015910-d9gxew91	470	41	for	for	IN
cord-015910-d9gxew91	470	42	ventilator	ventilator	NN
cord-015910-d9gxew91	470	43	support	support	NN
cord-015910-d9gxew91	470	44	,	,	,
cord-015910-d9gxew91	470	45	and	and	CC
cord-015910-d9gxew91	470	46	spent	spend	VBD
cord-015910-d9gxew91	470	47	19	19	CD
cord-015910-d9gxew91	470	48	fewer	few	JJR
cord-015910-d9gxew91	470	49	days	day	NNS
cord-015910-d9gxew91	470	50	in	in	IN
cord-015910-d9gxew91	470	51	intensive	intensive	JJ
cord-015910-d9gxew91	470	52	care	care	NN
cord-015910-d9gxew91	470	53	than	than	IN
cord-015910-d9gxew91	470	54	patients	patient	NNS
cord-015910-d9gxew91	470	55	not	not	RB
cord-015910-d9gxew91	470	56	receiving	receive	VBG
cord-015910-d9gxew91	470	57	NAC	NAC	NNP
cord-015910-d9gxew91	470	58	(	(	-LRB-
cord-015910-d9gxew91	470	59	Spapen	Spapen	NNP
cord-015910-d9gxew91	470	60	et	et	FW
cord-015910-d9gxew91	470	61	al	al	NNP
cord-015910-d9gxew91	470	62	.	.	NNP
cord-015910-d9gxew91	470	63	,	,	,
cord-015910-d9gxew91	470	64	1998	1998	CD
cord-015910-d9gxew91	470	65	)	)	-RRB-
cord-015910-d9gxew91	470	66	.	.	.
cord-015910-d9gxew91	471	1	De	De	NNP
cord-015910-d9gxew91	471	2	Rosa	Rosa	NNP
cord-015910-d9gxew91	471	3	et	et	NNP
cord-015910-d9gxew91	471	4	al	al	NNP
cord-015910-d9gxew91	471	5	.	.	.
cord-015910-d9gxew91	472	1	(	(	-LRB-
cord-015910-d9gxew91	472	2	2000	2000	CD
cord-015910-d9gxew91	472	3	showed	show	VBD
cord-015910-d9gxew91	472	4	that	that	IN
cord-015910-d9gxew91	472	5	NAC	NAC	NNP
cord-015910-d9gxew91	472	6	was	be	VBD
cord-015910-d9gxew91	472	7	able	able	JJ
cord-015910-d9gxew91	472	8	to	to	TO
cord-015910-d9gxew91	472	9	restore	restore	VB
cord-015910-d9gxew91	472	10	tissue	tissue	NN
cord-015910-d9gxew91	472	11	GSH	GSH	NNP
cord-015910-d9gxew91	472	12	concentrations	concentration	NNS
cord-015910-d9gxew91	472	13	in	in	IN
cord-015910-d9gxew91	472	14	individuals	individual	NNS
cord-015910-d9gxew91	472	15	with	with	IN
cord-015910-d9gxew91	472	16	HIV	HIV	NNP
cord-015910-d9gxew91	472	17	infection	infection	NN
cord-015910-d9gxew91	472	18	.	.	.
cord-015910-d9gxew91	473	1	In	in	IN
cord-015910-d9gxew91	473	2	a	a	DT
cord-015910-d9gxew91	473	3	study	study	NN
cord-015910-d9gxew91	473	4	on	on	IN
cord-015910-d9gxew91	473	5	HIV	HIV	NNP
cord-015910-d9gxew91	473	6	-	-	HYPH
cord-015910-d9gxew91	473	7	positive	positive	JJ
cord-015910-d9gxew91	473	8	patients	patient	NNS
cord-015910-d9gxew91	473	9	,	,	,
cord-015910-d9gxew91	473	10	Brietkreutz	Brietkreutz	NNP
cord-015910-d9gxew91	473	11	et	et	NNP
cord-015910-d9gxew91	473	12	al	al	NNP
cord-015910-d9gxew91	473	13	.	.	.
cord-015910-d9gxew91	474	1	(	(	-LRB-
cord-015910-d9gxew91	474	2	2000	2000	CD
cord-015910-d9gxew91	474	3	)	)	-RRB-
cord-015910-d9gxew91	474	4	showed	show	VBD
cord-015910-d9gxew91	474	5	that	that	IN
cord-015910-d9gxew91	474	6	a	a	DT
cord-015910-d9gxew91	474	7	dose	dose	NN
cord-015910-d9gxew91	474	8	of	of	IN
cord-015910-d9gxew91	474	9	600	600	CD
cord-015910-d9gxew91	474	10	mg	mg	NN
cord-015910-d9gxew91	474	11	/	/	SYM
cord-015910-d9gxew91	474	12	d	d	NN
cord-015910-d9gxew91	474	13	of	of	IN
cord-015910-d9gxew91	474	14	NAC	NAC	NNP
cord-015910-d9gxew91	474	15	for	for	IN
cord-015910-d9gxew91	474	16	7	7	CD
cord-015910-d9gxew91	474	17	mo	mo	NNP
cord-015910-d9gxew91	474	18	resulted	result	VBD
cord-015910-d9gxew91	474	19	in	in	IN
cord-015910-d9gxew91	474	20	a	a	DT
cord-015910-d9gxew91	474	21	decrease	decrease	NN
cord-015910-d9gxew91	474	22	in	in	IN
cord-015910-d9gxew91	474	23	plasma	plasma	NN
cord-015910-d9gxew91	474	24	IL-6	IL-6	NNP
cord-015910-d9gxew91	474	25	(	(	-LRB-
cord-015910-d9gxew91	474	26	decreased	decrease	VBN
cord-015910-d9gxew91	474	27	inflammation	inflammation	NN
cord-015910-d9gxew91	474	28	)	)	-RRB-
cord-015910-d9gxew91	474	29	,	,	,
cord-015910-d9gxew91	474	30	an	an	DT
cord-015910-d9gxew91	474	31	increase	increase	NN
cord-015910-d9gxew91	474	32	in	in	IN
cord-015910-d9gxew91	474	33	natural	natural	JJ
cord-015910-d9gxew91	474	34	killer	killer	NN
cord-015910-d9gxew91	474	35	cell	cell	NN
cord-015910-d9gxew91	474	36	activity	activity	NN
cord-015910-d9gxew91	474	37	,	,	,
cord-015910-d9gxew91	474	38	and	and	CC
cord-015910-d9gxew91	474	39	increased	increase	VBN
cord-015910-d9gxew91	474	40	responsiveness	responsiveness	NN
cord-015910-d9gxew91	474	41	of	of	IN
cord-015910-d9gxew91	474	42	T	t	NN
cord-015910-d9gxew91	474	43	lymphocytes	lymphocyte	NNS
cord-015910-d9gxew91	474	44	to	to	IN
cord-015910-d9gxew91	474	45	tetanus	tetanus	JJ
cord-015910-d9gxew91	474	46	toxin	toxin	NN
cord-015910-d9gxew91	474	47	stimulation	stimulation	NN
cord-015910-d9gxew91	474	48	(	(	-LRB-
cord-015910-d9gxew91	474	49	improved	improved	JJ
cord-015910-d9gxew91	474	50	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	474	51	function	function	NN
cord-015910-d9gxew91	474	52	)	)	-RRB-
cord-015910-d9gxew91	474	53	.	.	.
cord-015910-d9gxew91	475	1	Antioxidants	antioxidant	NNS
cord-015910-d9gxew91	475	2	might	may	MD
cord-015910-d9gxew91	475	3	act	act	VB
cord-015910-d9gxew91	475	4	to	to	TO
cord-015910-d9gxew91	475	5	prevent	prevent	VB
cord-015910-d9gxew91	475	6	NF	nf	NN
cord-015910-d9gxew91	475	7	-	-	HYPH
cord-015910-d9gxew91	475	8	r	r	NN
cord-015910-d9gxew91	475	9	,	,	,
cord-015910-d9gxew91	475	10	B	b	NN
cord-015910-d9gxew91	475	11	activation	activation	NN
cord-015910-d9gxew91	475	12	by	by	IN
cord-015910-d9gxew91	475	13	quenching	quench	VBG
cord-015910-d9gxew91	475	14	oxidants	oxidant	NNS
cord-015910-d9gxew91	475	15	.	.	.
cord-015910-d9gxew91	476	1	However	however	RB
cord-015910-d9gxew91	476	2	,	,	,
cord-015910-d9gxew91	476	3	NF	NF	NNP
cord-015910-d9gxew91	476	4	-	-	HYPH
cord-015910-d9gxew91	476	5	rd3	rd3	NNP
cord-015910-d9gxew91	476	6	and	and	CC
cord-015910-d9gxew91	476	7	AP1	AP1	NNP
cord-015910-d9gxew91	476	8	may	may	MD
cord-015910-d9gxew91	476	9	not	not	RB
cord-015910-d9gxew91	476	10	respond	respond	VB
cord-015910-d9gxew91	476	11	to	to	IN
cord-015910-d9gxew91	476	12	changes	change	NNS
cord-015910-d9gxew91	476	13	in	in	IN
cord-015910-d9gxew91	476	14	cell	cell	NN
cord-015910-d9gxew91	476	15	redox	redox	NN
cord-015910-d9gxew91	476	16	state	state	NN
cord-015910-d9gxew91	476	17	in	in	IN
cord-015910-d9gxew91	476	18	the	the	DT
cord-015910-d9gxew91	476	19	same	same	JJ
cord-015910-d9gxew91	476	20	way	way	NN
cord-015910-d9gxew91	476	21	.	.	.
cord-015910-d9gxew91	477	1	When	when	WRB
cord-015910-d9gxew91	477	2	rats	rat	NNS
cord-015910-d9gxew91	477	3	were	be	VBD
cord-015910-d9gxew91	477	4	subjected	subject	VBN
cord-015910-d9gxew91	477	5	to	to	IN
cord-015910-d9gxew91	477	6	depletion	depletion	NN
cord-015910-d9gxew91	477	7	of	of	IN
cord-015910-d9gxew91	477	8	effective	effective	JJ
cord-015910-d9gxew91	477	9	tissue	tissue	NN
cord-015910-d9gxew91	477	10	GSH	GSH	NNP
cord-015910-d9gxew91	477	11	pools	pool	NNS
cord-015910-d9gxew91	477	12	by	by	IN
cord-015910-d9gxew91	477	13	administration	administration	NN
cord-015910-d9gxew91	477	14	of	of	IN
cord-015910-d9gxew91	477	15	diethyl	diethyl	NNP
cord-015910-d9gxew91	477	16	maleate	maleate	NNP
cord-015910-d9gxew91	477	17	,	,	,
cord-015910-d9gxew91	477	18	there	there	EX
cord-015910-d9gxew91	477	19	was	be	VBD
cord-015910-d9gxew91	477	20	a	a	DT
cord-015910-d9gxew91	477	21	significant	significant	JJ
cord-015910-d9gxew91	477	22	reduction	reduction	NN
cord-015910-d9gxew91	477	23	in	in	IN
cord-015910-d9gxew91	477	24	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	477	25	proliferation	proliferation	NN
cord-015910-d9gxew91	477	26	in	in	IN
cord-015910-d9gxew91	477	27	spleen	spleen	NN
cord-015910-d9gxew91	477	28	and	and	CC
cord-015910-d9gxew91	477	29	mesenteric	mesenteric	JJ
cord-015910-d9gxew91	477	30	lymph	lymph	NN
cord-015910-d9gxew91	477	31	nodes	node	NNS
cord-015910-d9gxew91	477	32	(	(	-LRB-
cord-015910-d9gxew91	477	33	Robinson	Robinson	NNP
cord-015910-d9gxew91	477	34	et	et	NNP
cord-015910-d9gxew91	477	35	al	al	NNP
cord-015910-d9gxew91	477	36	.	.	NNP
cord-015910-d9gxew91	477	37	,	,	,
cord-015910-d9gxew91	477	38	1993	1993	CD
cord-015910-d9gxew91	477	39	)	)	-RRB-
cord-015910-d9gxew91	477	40	.	.	.
cord-015910-d9gxew91	478	1	An	an	DT
cord-015910-d9gxew91	478	2	increase	increase	NN
cord-015910-d9gxew91	478	3	in	in	IN
cord-015910-d9gxew91	478	4	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	478	5	stress	stress	NN
cord-015910-d9gxew91	478	6	would	would	MD
cord-015910-d9gxew91	478	7	be	be	VB
cord-015910-d9gxew91	478	8	expected	expect	VBN
cord-015910-d9gxew91	478	9	in	in	IN
cord-015910-d9gxew91	478	10	this	this	DT
cord-015910-d9gxew91	478	11	study	study	NN
cord-015910-d9gxew91	478	12	.	.	.
cord-015910-d9gxew91	479	1	Thus	thus	RB
cord-015910-d9gxew91	479	2	,	,	,
cord-015910-d9gxew91	479	3	it	-PRON-	PRP
cord-015910-d9gxew91	479	4	can	can	MD
cord-015910-d9gxew91	479	5	be	be	VB
cord-015910-d9gxew91	479	6	hypothesized	hypothesize	VBN
cord-015910-d9gxew91	479	7	that	that	IN
cord-015910-d9gxew91	479	8	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	479	9	exert	exert	VBP
cord-015910-d9gxew91	479	10	an	an	DT
cord-015910-d9gxew91	479	11	immunoenhancing	immunoenhancing	NN
cord-015910-d9gxew91	479	12	effect	effect	NN
cord-015910-d9gxew91	479	13	by	by	IN
cord-015910-d9gxew91	479	14	activating	activate	VBG
cord-015910-d9gxew91	479	15	transcription	transcription	NN
cord-015910-d9gxew91	479	16	factors	factor	NNS
cord-015910-d9gxew91	479	17	that	that	WDT
cord-015910-d9gxew91	479	18	are	be	VBP
cord-015910-d9gxew91	479	19	strongly	strongly	RB
cord-015910-d9gxew91	479	20	associated	associate	VBN
cord-015910-d9gxew91	479	21	with	with	IN
cord-015910-d9gxew91	479	22	cell	cell	NN
cord-015910-d9gxew91	479	23	proliferation	proliferation	NN
cord-015910-d9gxew91	479	24	(	(	-LRB-
cord-015910-d9gxew91	479	25	e.g.	e.g.	RB
cord-015910-d9gxew91	479	26	,	,	,
cord-015910-d9gxew91	479	27	AP	AP	NNP
cord-015910-d9gxew91	479	28	1	1	CD
cord-015910-d9gxew91	479	29	)	)	-RRB-
cord-015910-d9gxew91	479	30	and	and	CC
cord-015910-d9gxew91	479	31	an	an	DT
cord-015910-d9gxew91	479	32	anti	anti	JJ
cord-015910-d9gxew91	479	33	-	-	JJ
cord-015910-d9gxew91	479	34	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	479	35	effect	effect	NN
cord-015910-d9gxew91	479	36	by	by	IN
cord-015910-d9gxew91	479	37	preventing	prevent	VBG
cord-015910-d9gxew91	479	38	activation	activation	NN
cord-015910-d9gxew91	479	39	of	of	IN
cord-015910-d9gxew91	479	40	NF	nf	NN
cord-015910-d9gxew91	479	41	-	-	HYPH
cord-015910-d9gxew91	479	42	r	r	NNP
cord-015910-d9gxew91	479	43	,	,	,
cord-015910-d9gxew91	479	44	B	b	NN
cord-015910-d9gxew91	479	45	by	by	IN
cord-015910-d9gxew91	479	46	oxidants	oxidant	NNS
cord-015910-d9gxew91	479	47	produced	produce	VBN
cord-015910-d9gxew91	479	48	during	during	IN
cord-015910-d9gxew91	479	49	the	the	DT
cord-015910-d9gxew91	479	50	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	479	51	response	response	NN
cord-015910-d9gxew91	479	52	(	(	-LRB-
cord-015910-d9gxew91	479	53	Dr&ouml	Dr&ouml	NNP
cord-015910-d9gxew91	479	54	;	;	:
cord-015910-d9gxew91	479	55	ge	ge	NNP
cord-015910-d9gxew91	479	56	et	et	NNP
cord-015910-d9gxew91	479	57	al	al	NNP
cord-015910-d9gxew91	479	58	.	.	NNP
cord-015910-d9gxew91	479	59	,	,	,
cord-015910-d9gxew91	479	60	1994	1994	CD
cord-015910-d9gxew91	479	61	)	)	-RRB-
cord-015910-d9gxew91	479	62	.Thus	.Thus	.
cord-015910-d9gxew91	480	1	,	,	,
cord-015910-d9gxew91	480	2	inclusion	inclusion	NN
cord-015910-d9gxew91	480	3	of	of	IN
cord-015910-d9gxew91	480	4	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	480	5	or	or	CC
cord-015910-d9gxew91	480	6	substances	substance	NNS
cord-015910-d9gxew91	480	7	that	that	WDT
cord-015910-d9gxew91	480	8	increase	increase	VBP
cord-015910-d9gxew91	480	9	GSH	GSH	NNP
cord-015910-d9gxew91	480	10	synthesis	synthesis	NN
cord-015910-d9gxew91	480	11	in	in	IN
cord-015910-d9gxew91	480	12	immunonutrient	immunonutrient	NN
cord-015910-d9gxew91	480	13	mixes	mix	NNS
cord-015910-d9gxew91	480	14	would	would	MD
cord-015910-d9gxew91	480	15	seem	seem	VB
cord-015910-d9gxew91	480	16	to	to	TO
cord-015910-d9gxew91	480	17	be	be	VB
cord-015910-d9gxew91	480	18	beneficial	beneficial	JJ
cord-015910-d9gxew91	480	19	.	.	.
cord-015910-d9gxew91	481	1	Improvement	improvement	NN
cord-015910-d9gxew91	481	2	of	of	IN
cord-015910-d9gxew91	481	3	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	481	4	defenses	defense	NNS
cord-015910-d9gxew91	481	5	is	be	VBZ
cord-015910-d9gxew91	481	6	also	also	RB
cord-015910-d9gxew91	481	7	possible	possible	JJ
cord-015910-d9gxew91	481	8	by	by	IN
cord-015910-d9gxew91	481	9	feeding	feed	VBG
cord-015910-d9gxew91	481	10	other	other	JJ
cord-015910-d9gxew91	481	11	components	component	NNS
cord-015910-d9gxew91	481	12	of	of	IN
cord-015910-d9gxew91	481	13	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	481	14	defenses	defense	NNS
cord-015910-d9gxew91	481	15	.	.	.
cord-015910-d9gxew91	482	1	Supplementation	supplementation	NN
cord-015910-d9gxew91	482	2	of	of	IN
cord-015910-d9gxew91	482	3	the	the	DT
cord-015910-d9gxew91	482	4	diet	diet	NN
cord-015910-d9gxew91	482	5	of	of	IN
cord-015910-d9gxew91	482	6	healthy	healthy	JJ
cord-015910-d9gxew91	482	7	subjects	subject	NNS
cord-015910-d9gxew91	482	8	and	and	CC
cord-015910-d9gxew91	482	9	smokers	smoker	NNS
cord-015910-d9gxew91	482	10	with	with	IN
cord-015910-d9gxew91	482	11	600	600	CD
cord-015910-d9gxew91	482	12	IU	IU	NNP
cord-015910-d9gxew91	482	13	/	/	,
cord-015910-d9gxew91	482	14	d	d	NN
cord-015910-d9gxew91	483	1	t~-tocopherol	t~-tocopherol	NNP
cord-015910-d9gxew91	483	2	for	for	IN
cord-015910-d9gxew91	483	3	4	4	CD
cord-015910-d9gxew91	483	4	wk	wk	NNS
cord-015910-d9gxew91	483	5	suppressed	suppress	VBD
cord-015910-d9gxew91	483	6	the	the	DT
cord-015910-d9gxew91	483	7	ability	ability	NN
cord-015910-d9gxew91	483	8	of	of	IN
cord-015910-d9gxew91	483	9	PBMCs	pbmc	NNS
cord-015910-d9gxew91	483	10	to	to	TO
cord-015910-d9gxew91	483	11	produce	produce	VB
cord-015910-d9gxew91	483	12	TNF	TNF	NNP
cord-015910-d9gxew91	483	13	-	-	HYPH
cord-015910-d9gxew91	483	14	t~	t~	NNP
cord-015910-d9gxew91	484	1	(	(	-LRB-
cord-015910-d9gxew91	484	2	Mol	Mol	NNP
cord-015910-d9gxew91	484	3	,	,	,
cord-015910-d9gxew91	484	4	de	de	NNP
cord-015910-d9gxew91	484	5	Rijke	Rijke	NNP
cord-015910-d9gxew91	484	6	,	,	,
cord-015910-d9gxew91	484	7	Demacher	Demacher	NNP
cord-015910-d9gxew91	484	8	,	,	,
cord-015910-d9gxew91	484	9	&	&	CC
cord-015910-d9gxew91	484	10	Stalenhoef	Stalenhoef	NNP
cord-015910-d9gxew91	484	11	,	,	,
cord-015910-d9gxew91	484	12	1997	1997	CD
cord-015910-d9gxew91	484	13	)	)	-RRB-
cord-015910-d9gxew91	484	14	.	.	.
cord-015910-d9gxew91	485	1	The	the	DT
cord-015910-d9gxew91	485	2	same	same	JJ
cord-015910-d9gxew91	485	3	dose	dose	NN
cord-015910-d9gxew91	485	4	given	give	VBN
cord-015910-d9gxew91	485	5	to	to	IN
cord-015910-d9gxew91	485	6	healthy	healthy	JJ
cord-015910-d9gxew91	485	7	elderly	elderly	JJ
cord-015910-d9gxew91	485	8	subjects	subject	NNS
cord-015910-d9gxew91	485	9	for	for	IN
cord-015910-d9gxew91	485	10	235	235	CD
cord-015910-d9gxew91	485	11	d	d	NN
cord-015910-d9gxew91	485	12	increased	increase	VBN
cord-015910-d9gxew91	485	13	delayed	delay	VBN
cord-015910-d9gxew91	485	14	-	-	HYPH
cord-015910-d9gxew91	485	15	type	type	NN
cord-015910-d9gxew91	485	16	hypersensitivity	hypersensitivity	NN
cord-015910-d9gxew91	485	17	and	and	CC
cord-015910-d9gxew91	485	18	raised	raise	VBN
cord-015910-d9gxew91	485	19	antibody	antibody	NN
cord-015910-d9gxew91	485	20	titers	titer	NNS
cord-015910-d9gxew91	485	21	to	to	IN
cord-015910-d9gxew91	485	22	hepatitis	hepatitis	NNP
cord-015910-d9gxew91	485	23	B	B	NNP
cord-015910-d9gxew91	485	24	(	(	-LRB-
cord-015910-d9gxew91	485	25	Meydani	Meydani	NNP
cord-015910-d9gxew91	485	26	et	et	NNP
cord-015910-d9gxew91	485	27	al	al	NNP
cord-015910-d9gxew91	485	28	.	.	NNP
cord-015910-d9gxew91	485	29	,	,	,
cord-015910-d9gxew91	485	30	1997	1997	CD
cord-015910-d9gxew91	485	31	)	)	-RRB-
cord-015910-d9gxew91	485	32	.	.	.
cord-015910-d9gxew91	486	1	An	an	DT
cord-015910-d9gxew91	486	2	enteral	enteral	NN
cord-015910-d9gxew91	486	3	feed	feed	NN
cord-015910-d9gxew91	486	4	enriched	enrich	VBN
cord-015910-d9gxew91	486	5	with	with	IN
cord-015910-d9gxew91	486	6	vitamin	vitamin	NN
cord-015910-d9gxew91	486	7	E	e	NN
cord-015910-d9gxew91	486	8	,	,	,
cord-015910-d9gxew91	486	9	vitamin	vitamin	NN
cord-015910-d9gxew91	486	10	C	c	NN
cord-015910-d9gxew91	486	11	,	,	,
cord-015910-d9gxew91	486	12	and	and	CC
cord-015910-d9gxew91	486	13	taurine	taurine	NN
cord-015910-d9gxew91	486	14	given	give	VBN
cord-015910-d9gxew91	486	15	to	to	IN
cord-015910-d9gxew91	486	16	intensive	intensive	JJ
cord-015910-d9gxew91	486	17	-	-	HYPH
cord-015910-d9gxew91	486	18	care	care	NN
cord-015910-d9gxew91	486	19	patients	patient	NNS
cord-015910-d9gxew91	486	20	decreased	decrease	VBD
cord-015910-d9gxew91	486	21	total	total	JJ
cord-015910-d9gxew91	486	22	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	486	23	and	and	CC
cord-015910-d9gxew91	486	24	neutrophil	neutrophil	NN
cord-015910-d9gxew91	486	25	content	content	NN
cord-015910-d9gxew91	486	26	in	in	IN
cord-015910-d9gxew91	486	27	bronchioalveolar	bronchioalveolar	NNP
cord-015910-d9gxew91	486	28	lavage	lavage	NN
cord-015910-d9gxew91	486	29	fluid	fluid	NN
cord-015910-d9gxew91	486	30	(	(	-LRB-
cord-015910-d9gxew91	486	31	decreased	decreased	JJ
cord-015910-d9gxew91	486	32	inflammation	inflammation	NN
cord-015910-d9gxew91	486	33	)	)	-RRB-
cord-015910-d9gxew91	486	34	and	and	CC
cord-015910-d9gxew91	486	35	resulted	result	VBD
cord-015910-d9gxew91	486	36	in	in	IN
cord-015910-d9gxew91	486	37	a	a	DT
cord-015910-d9gxew91	486	38	reduction	reduction	NN
cord-015910-d9gxew91	486	39	in	in	IN
cord-015910-d9gxew91	486	40	organ	organ	NN
cord-015910-d9gxew91	486	41	failure	failure	NN
cord-015910-d9gxew91	486	42	rate	rate	NN
cord-015910-d9gxew91	486	43	,	,	,
cord-015910-d9gxew91	486	44	a	a	DT
cord-015910-d9gxew91	486	45	reduced	reduce	VBN
cord-015910-d9gxew91	486	46	requirement	requirement	NN
cord-015910-d9gxew91	486	47	for	for	IN
cord-015910-d9gxew91	486	48	artificial	artificial	JJ
cord-015910-d9gxew91	486	49	ventilation	ventilation	NN
cord-015910-d9gxew91	486	50	,	,	,
cord-015910-d9gxew91	486	51	and	and	CC
cord-015910-d9gxew91	486	52	a	a	DT
cord-015910-d9gxew91	486	53	reduction	reduction	NN
cord-015910-d9gxew91	486	54	of	of	IN
cord-015910-d9gxew91	486	55	5	5	CD
cord-015910-d9gxew91	486	56	d	d	NN
cord-015910-d9gxew91	486	57	in	in	IN
cord-015910-d9gxew91	486	58	intensive	intensive	JJ
cord-015910-d9gxew91	486	59	-	-	HYPH
cord-015910-d9gxew91	486	60	care	care	NN
cord-015910-d9gxew91	486	61	stay	stay	NN
cord-015910-d9gxew91	487	1	(	(	-LRB-
cord-015910-d9gxew91	487	2	Gadek	Gadek	NNP
cord-015910-d9gxew91	487	3	et	et	NNP
cord-015910-d9gxew91	487	4	al	al	NNP
cord-015910-d9gxew91	487	5	.	.	NNP
cord-015910-d9gxew91	487	6	,	,	,
cord-015910-d9gxew91	487	7	1999	1999	CD
cord-015910-d9gxew91	487	8	)	)	-RRB-
cord-015910-d9gxew91	487	9	.	.	.
cord-015910-d9gxew91	488	1	A	a	DT
cord-015910-d9gxew91	488	2	number	number	NN
cord-015910-d9gxew91	488	3	of	of	IN
cord-015910-d9gxew91	488	4	roles	role	NNS
cord-015910-d9gxew91	488	5	have	have	VBP
cord-015910-d9gxew91	488	6	been	be	VBN
cord-015910-d9gxew91	488	7	ascribed	ascribe	VBN
cord-015910-d9gxew91	488	8	to	to	IN
cord-015910-d9gxew91	488	9	glutamine	glutamine	NN
cord-015910-d9gxew91	488	10	as	as	IN
cord-015910-d9gxew91	488	11	an	an	DT
cord-015910-d9gxew91	488	12	immunonutrient	immunonutrient	NN
cord-015910-d9gxew91	488	13	:	:	:
cord-015910-d9gxew91	488	14	(	(	-LRB-
cord-015910-d9gxew91	488	15	a	a	LS
cord-015910-d9gxew91	488	16	)	)	-RRB-
cord-015910-d9gxew91	488	17	as	as	IN
cord-015910-d9gxew91	488	18	an	an	DT
cord-015910-d9gxew91	488	19	essential	essential	JJ
cord-015910-d9gxew91	488	20	nutrient	nutrient	NN
cord-015910-d9gxew91	488	21	for	for	IN
cord-015910-d9gxew91	488	22	immune	immune	JJ
cord-015910-d9gxew91	488	23	cells	cell	NNS
cord-015910-d9gxew91	488	24	,	,	,
cord-015910-d9gxew91	488	25	(	(	-LRB-
cord-015910-d9gxew91	488	26	b	b	NN
cord-015910-d9gxew91	488	27	)	)	-RRB-
cord-015910-d9gxew91	488	28	as	as	IN
cord-015910-d9gxew91	488	29	an	an	DT
cord-015910-d9gxew91	488	30	important	important	JJ
cord-015910-d9gxew91	488	31	modulator	modulator	NN
cord-015910-d9gxew91	488	32	of	of	IN
cord-015910-d9gxew91	488	33	gut	gut	NN
cord-015910-d9gxew91	488	34	barrier	barrier	NN
cord-015910-d9gxew91	488	35	function	function	NN
cord-015910-d9gxew91	488	36	,	,	,
cord-015910-d9gxew91	488	37	and	and	CC
cord-015910-d9gxew91	488	38	(	(	-LRB-
cord-015910-d9gxew91	488	39	c	c	NN
cord-015910-d9gxew91	488	40	)	)	-RRB-
cord-015910-d9gxew91	488	41	as	as	IN
cord-015910-d9gxew91	488	42	a	a	DT
cord-015910-d9gxew91	488	43	substrate	substrate	NN
cord-015910-d9gxew91	488	44	for	for	IN
cord-015910-d9gxew91	488	45	GSH	GSH	NNP
cord-015910-d9gxew91	488	46	synthesis	synthesis	NN
cord-015910-d9gxew91	488	47	.	.	.
cord-015910-d9gxew91	489	1	A	a	DT
cord-015910-d9gxew91	489	2	number	number	NN
cord-015910-d9gxew91	489	3	of	of	IN
cord-015910-d9gxew91	489	4	reviews	review	NNS
cord-015910-d9gxew91	489	5	have	have	VBP
cord-015910-d9gxew91	489	6	been	be	VBN
cord-015910-d9gxew91	489	7	written	write	VBN
cord-015910-d9gxew91	489	8	about	about	IN
cord-015910-d9gxew91	489	9	the	the	DT
cord-015910-d9gxew91	489	10	first	first	JJ
cord-015910-d9gxew91	489	11	two	two	CD
cord-015910-d9gxew91	489	12	of	of	IN
cord-015910-d9gxew91	489	13	these	these	DT
cord-015910-d9gxew91	489	14	roles	role	NNS
cord-015910-d9gxew91	489	15	(	(	-LRB-
cord-015910-d9gxew91	489	16	Newsholme	Newsholme	NNP
cord-015910-d9gxew91	489	17	,	,	,
cord-015910-d9gxew91	489	18	Crabtree	Crabtree	NNP
cord-015910-d9gxew91	489	19	,	,	,
cord-015910-d9gxew91	489	20	Salleh	Salleh	NNP
cord-015910-d9gxew91	489	21	,	,	,
cord-015910-d9gxew91	489	22	&	&	CC
cord-015910-d9gxew91	489	23	Ardawi	Ardawi	NNP
cord-015910-d9gxew91	489	24	,	,	,
cord-015910-d9gxew91	489	25	1985	1985	CD
cord-015910-d9gxew91	489	26	;	;	:
cord-015910-d9gxew91	489	27	Elia	Elia	NNP
cord-015910-d9gxew91	489	28	,	,	,
cord-015910-d9gxew91	489	29	1992	1992	CD
cord-015910-d9gxew91	489	30	)	)	-RRB-
cord-015910-d9gxew91	489	31	;	;	:
cord-015910-d9gxew91	489	32	we	-PRON-	PRP
cord-015910-d9gxew91	489	33	will	will	MD
cord-015910-d9gxew91	489	34	consider	consider	VB
cord-015910-d9gxew91	489	35	the	the	DT
cord-015910-d9gxew91	489	36	last	last	JJ
cord-015910-d9gxew91	489	37	one	one	NN
cord-015910-d9gxew91	489	38	here	here	RB
cord-015910-d9gxew91	489	39	.	.	.
cord-015910-d9gxew91	490	1	Could	Could	MD
cord-015910-d9gxew91	490	2	glutamine	glutamine	NN
cord-015910-d9gxew91	490	3	be	be	VB
cord-015910-d9gxew91	490	4	exerting	exert	VBG
cord-015910-d9gxew91	490	5	an	an	DT
cord-015910-d9gxew91	490	6	anti	anti	JJ
cord-015910-d9gxew91	490	7	-	-	JJ
cord-015910-d9gxew91	490	8	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	490	9	influence	influence	NN
cord-015910-d9gxew91	490	10	via	via	IN
cord-015910-d9gxew91	490	11	an	an	DT
cord-015910-d9gxew91	490	12	effect	effect	NN
cord-015910-d9gxew91	490	13	on	on	IN
cord-015910-d9gxew91	490	14	GSH	GSH	NNP
cord-015910-d9gxew91	490	15	that	that	WDT
cord-015910-d9gxew91	490	16	enhances	enhance	VBZ
cord-015910-d9gxew91	490	17	immune	immune	JJ
cord-015910-d9gxew91	490	18	function	function	NN
cord-015910-d9gxew91	490	19	?	?	.
cord-015910-d9gxew91	491	1	In	in	IN
cord-015910-d9gxew91	491	2	a	a	DT
cord-015910-d9gxew91	491	3	study	study	NN
cord-015910-d9gxew91	491	4	in	in	IN
cord-015910-d9gxew91	491	5	rats	rat	NNS
cord-015910-d9gxew91	491	6	,	,	,
cord-015910-d9gxew91	491	7	glutamine	glutamine	NN
cord-015910-d9gxew91	491	8	supplementation	supplementation	NN
cord-015910-d9gxew91	491	9	resulted	result	VBD
cord-015910-d9gxew91	491	10	in	in	IN
cord-015910-d9gxew91	491	11	an	an	DT
cord-015910-d9gxew91	491	12	increased	increase	VBN
cord-015910-d9gxew91	491	13	production	production	NN
cord-015910-d9gxew91	491	14	of	of	IN
cord-015910-d9gxew91	491	15	GSH	GSH	NNP
cord-015910-d9gxew91	491	16	by	by	IN
cord-015910-d9gxew91	491	17	the	the	DT
cord-015910-d9gxew91	491	18	gut	gut	NN
cord-015910-d9gxew91	491	19	(	(	-LRB-
cord-015910-d9gxew91	491	20	Cao	Cao	NNP
cord-015910-d9gxew91	491	21	,	,	,
cord-015910-d9gxew91	491	22	Feng	Feng	NNP
cord-015910-d9gxew91	491	23	,	,	,
cord-015910-d9gxew91	491	24	Hoos	Hoos	NNP
cord-015910-d9gxew91	491	25	,	,	,
cord-015910-d9gxew91	491	26	&	&	CC
cord-015910-d9gxew91	491	27	Klimberg	Klimberg	NNP
cord-015910-d9gxew91	491	28	,	,	,
cord-015910-d9gxew91	491	29	1998	1998	CD
cord-015910-d9gxew91	491	30	)	)	-RRB-
cord-015910-d9gxew91	491	31	,	,	,
cord-015910-d9gxew91	491	32	and	and	CC
cord-015910-d9gxew91	491	33	total	total	JJ
cord-015910-d9gxew91	491	34	parenteral	parenteral	JJ
cord-015910-d9gxew91	491	35	nutrition	nutrition	NN
cord-015910-d9gxew91	491	36	(	(	-LRB-
cord-015910-d9gxew91	491	37	TPN	TPN	NNP
cord-015910-d9gxew91	491	38	)	)	-RRB-
cord-015910-d9gxew91	491	39	with	with	IN
cord-015910-d9gxew91	491	40	glutamine	glutamine	NN
cord-015910-d9gxew91	491	41	raised	raise	VBN
cord-015910-d9gxew91	491	42	plasma	plasma	NN
cord-015910-d9gxew91	491	43	GSH	GSH	NNP
cord-015910-d9gxew91	491	44	concentrations	concentration	NNS
cord-015910-d9gxew91	491	45	in	in	IN
cord-015910-d9gxew91	491	46	these	these	DT
cord-015910-d9gxew91	491	47	animals	animal	NNS
cord-015910-d9gxew91	491	48	(	(	-LRB-
cord-015910-d9gxew91	491	49	Denno	Denno	NNP
cord-015910-d9gxew91	491	50	,	,	,
cord-015910-d9gxew91	491	51	Rounds	Rounds	NNP
cord-015910-d9gxew91	491	52	,	,	,
cord-015910-d9gxew91	491	53	Faris	Faris	NNP
cord-015910-d9gxew91	491	54	,	,	,
cord-015910-d9gxew91	491	55	Halejko	Halejko	NNP
cord-015910-d9gxew91	491	56	,	,	,
cord-015910-d9gxew91	491	57	&	&	CC
cord-015910-d9gxew91	491	58	Wilmore	Wilmore	NNP
cord-015910-d9gxew91	491	59	,	,	,
cord-015910-d9gxew91	491	60	1996	1996	CD
cord-015910-d9gxew91	491	61	)	)	-RRB-
cord-015910-d9gxew91	491	62	.	.	.
cord-015910-d9gxew91	492	1	In	in	IN
cord-015910-d9gxew91	492	2	randomized	randomized	JJ
cord-015910-d9gxew91	492	3	controlled	control	VBN
cord-015910-d9gxew91	492	4	trials	trial	NNS
cord-015910-d9gxew91	492	5	the	the	DT
cord-015910-d9gxew91	492	6	administration	administration	NN
cord-015910-d9gxew91	492	7	of	of	IN
cord-015910-d9gxew91	492	8	glutamine	glutamine	NNP
cord-015910-d9gxew91	492	9	,	,	,
cord-015910-d9gxew91	492	10	either	either	CC
cord-015910-d9gxew91	492	11	as	as	IN
cord-015910-d9gxew91	492	12	a	a	DT
cord-015910-d9gxew91	492	13	dipeptide	dipeptide	NN
cord-015910-d9gxew91	492	14	during	during	IN
cord-015910-d9gxew91	492	15	TPN	TPN	NNP
cord-015910-d9gxew91	492	16	to	to	IN
cord-015910-d9gxew91	492	17	surgical	surgical	JJ
cord-015910-d9gxew91	492	18	patients	patient	NNS
cord-015910-d9gxew91	492	19	or	or	CC
cord-015910-d9gxew91	492	20	as	as	IN
cord-015910-d9gxew91	492	21	a	a	DT
cord-015910-d9gxew91	492	22	glutamine	glutamine	NN
cord-015910-d9gxew91	492	23	-	-	HYPH
cord-015910-d9gxew91	492	24	enriched	enrich	VBN
cord-015910-d9gxew91	492	25	enteral	enteral	NN
cord-015910-d9gxew91	492	26	feed	feed	NN
cord-015910-d9gxew91	492	27	to	to	IN
cord-015910-d9gxew91	492	28	trauma	trauma	NN
cord-015910-d9gxew91	492	29	patients	patient	NNS
cord-015910-d9gxew91	492	30	,	,	,
cord-015910-d9gxew91	492	31	resulted	result	VBD
cord-015910-d9gxew91	492	32	,	,	,
cord-015910-d9gxew91	492	33	respectively	respectively	RB
cord-015910-d9gxew91	492	34	,	,	,
cord-015910-d9gxew91	492	35	in	in	IN
cord-015910-d9gxew91	492	36	improved	improve	VBN
cord-015910-d9gxew91	492	37	nitrogen	nitrogen	NN
cord-015910-d9gxew91	492	38	retention	retention	NN
cord-015910-d9gxew91	492	39	(	(	-LRB-
cord-015910-d9gxew91	492	40	less	less	JJR
cord-015910-d9gxew91	492	41	tissue	tissue	NN
cord-015910-d9gxew91	492	42	protein	protein	NN
cord-015910-d9gxew91	492	43	depletion	depletion	NN
cord-015910-d9gxew91	492	44	)	)	-RRB-
cord-015910-d9gxew91	492	45	and	and	CC
cord-015910-d9gxew91	492	46	a	a	DT
cord-015910-d9gxew91	492	47	6.2-d	6.2-d	CD
cord-015910-d9gxew91	492	48	reduction	reduction	NN
cord-015910-d9gxew91	492	49	in	in	IN
cord-015910-d9gxew91	492	50	hospital	hospital	NN
cord-015910-d9gxew91	492	51	stay	stay	NN
cord-015910-d9gxew91	492	52	,	,	,
cord-015910-d9gxew91	492	53	a	a	DT
cord-015910-d9gxew91	492	54	concomitant	concomitant	JJ
cord-015910-d9gxew91	492	55	suppression	suppression	NN
cord-015910-d9gxew91	492	56	of	of	IN
cord-015910-d9gxew91	492	57	the	the	DT
cord-015910-d9gxew91	492	58	rise	rise	NN
cord-015910-d9gxew91	492	59	in	in	IN
cord-015910-d9gxew91	492	60	plasma	plasma	NN
cord-015910-d9gxew91	492	61	-	-	HYPH
cord-015910-d9gxew91	492	62	soluble	soluble	JJ
cord-015910-d9gxew91	492	63	TNF	TNF	NNP
cord-015910-d9gxew91	492	64	receptors	receptor	NNS
cord-015910-d9gxew91	492	65	(	(	-LRB-
cord-015910-d9gxew91	492	66	reduced	reduce	VBN
cord-015910-d9gxew91	492	67	inflammation	inflammation	NN
cord-015910-d9gxew91	492	68	)	)	-RRB-
cord-015910-d9gxew91	492	69	,	,	,
cord-015910-d9gxew91	492	70	and	and	CC
cord-015910-d9gxew91	492	71	a	a	DT
cord-015910-d9gxew91	492	72	lower	low	JJR
cord-015910-d9gxew91	492	73	incidence	incidence	NN
cord-015910-d9gxew91	492	74	ofbacteremia	ofbacteremia	NN
cord-015910-d9gxew91	492	75	,	,	,
cord-015910-d9gxew91	492	76	pneumonia	pneumonia	NN
cord-015910-d9gxew91	492	77	,	,	,
cord-015910-d9gxew91	492	78	and	and	CC
cord-015910-d9gxew91	492	79	sepsis	sepsis	NN
cord-015910-d9gxew91	492	80	(	(	-LRB-
cord-015910-d9gxew91	492	81	improved	improve	VBN
cord-015910-d9gxew91	492	82	immune	immune	JJ
cord-015910-d9gxew91	492	83	function	function	NN
cord-015910-d9gxew91	492	84	)	)	-RRB-
cord-015910-d9gxew91	493	1	(	(	-LRB-
cord-015910-d9gxew91	493	2	Houdijk	Houdijk	NNP
cord-015910-d9gxew91	493	3	et	et	NNP
cord-015910-d9gxew91	493	4	al	al	NNP
cord-015910-d9gxew91	493	5	.	.	NNP
cord-015910-d9gxew91	493	6	,	,	,
cord-015910-d9gxew91	493	7	1998	1998	CD
cord-015910-d9gxew91	494	1	;	;	:
cord-015910-d9gxew91	494	2	Morlion	Morlion	NNP
cord-015910-d9gxew91	494	3	et	et	NNP
cord-015910-d9gxew91	494	4	al	al	NNP
cord-015910-d9gxew91	494	5	.	.	NNP
cord-015910-d9gxew91	494	6	,	,	,
cord-015910-d9gxew91	494	7	1998	1998	CD
cord-015910-d9gxew91	494	8	)	)	-RRB-
cord-015910-d9gxew91	494	9	 	 	_SP
cord-015910-d9gxew91	495	1	In	in	IN
cord-015910-d9gxew91	495	2	the	the	DT
cord-015910-d9gxew91	495	3	previous	previous	JJ
cord-015910-d9gxew91	495	4	section	section	NN
cord-015910-d9gxew91	495	5	the	the	DT
cord-015910-d9gxew91	495	6	influence	influence	NN
cord-015910-d9gxew91	495	7	of	of	IN
cord-015910-d9gxew91	495	8	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	495	9	on	on	IN
cord-015910-d9gxew91	495	10	severe	severe	JJ
cord-015910-d9gxew91	495	11	inflammation	inflammation	NN
cord-015910-d9gxew91	495	12	was	be	VBD
cord-015910-d9gxew91	495	13	considered	consider	VBN
cord-015910-d9gxew91	495	14	.	.	.
cord-015910-d9gxew91	496	1	Do	do	VB
cord-015910-d9gxew91	496	2	the	the	DT
cord-015910-d9gxew91	496	3	general	general	JJ
cord-015910-d9gxew91	496	4	findings	finding	NNS
cord-015910-d9gxew91	496	5	from	from	IN
cord-015910-d9gxew91	496	6	this	this	DT
cord-015910-d9gxew91	496	7	type	type	NN
cord-015910-d9gxew91	496	8	of	of	IN
cord-015910-d9gxew91	496	9	study	study	NN
cord-015910-d9gxew91	496	10	also	also	RB
cord-015910-d9gxew91	496	11	apply	apply	VBP
cord-015910-d9gxew91	496	12	to	to	IN
cord-015910-d9gxew91	496	13	modulation	modulation	NN
cord-015910-d9gxew91	496	14	of	of	IN
cord-015910-d9gxew91	496	15	low	low	JJ
cord-015910-d9gxew91	496	16	-	-	HYPH
cord-015910-d9gxew91	496	17	grade	grade	NN
cord-015910-d9gxew91	496	18	chronic	chronic	JJ
cord-015910-d9gxew91	496	19	inflammation	inflammation	NN
cord-015910-d9gxew91	496	20	,	,	,
cord-015910-d9gxew91	496	21	such	such	JJ
cord-015910-d9gxew91	496	22	as	as	IN
cord-015910-d9gxew91	496	23	has	have	VBZ
cord-015910-d9gxew91	496	24	been	be	VBN
cord-015910-d9gxew91	496	25	observed	observe	VBN
cord-015910-d9gxew91	496	26	in	in	IN
cord-015910-d9gxew91	496	27	the	the	DT
cord-015910-d9gxew91	496	28	elderly	elderly	JJ
cord-015910-d9gxew91	496	29	and	and	CC
cord-015910-d9gxew91	496	30	obese	obese	JJ
cord-015910-d9gxew91	496	31	?	?	.
cord-015910-d9gxew91	497	1	Because	because	IN
cord-015910-d9gxew91	497	2	aging	aging	NN
cord-015910-d9gxew91	497	3	is	be	VBZ
cord-015910-d9gxew91	497	4	so	so	RB
cord-015910-d9gxew91	497	5	closely	closely	RB
cord-015910-d9gxew91	497	6	associated	associate	VBN
cord-015910-d9gxew91	497	7	with	with	IN
cord-015910-d9gxew91	497	8	increased	increase	VBN
cord-015910-d9gxew91	497	9	oxidative	oxidative	JJ
cord-015910-d9gxew91	497	10	stress	stress	NN
cord-015910-d9gxew91	497	11	,	,	,
cord-015910-d9gxew91	497	12	which	which	WDT
cord-015910-d9gxew91	497	13	might	may	MD
cord-015910-d9gxew91	497	14	both	both	DT
cord-015910-d9gxew91	497	15	result	result	VB
cord-015910-d9gxew91	497	16	from	from	IN
cord-015910-d9gxew91	497	17	and	and	CC
cord-015910-d9gxew91	497	18	contribute	contribute	VB
cord-015910-d9gxew91	497	19	to	to	IN
cord-015910-d9gxew91	497	20	a	a	DT
cord-015910-d9gxew91	497	21	stimulation	stimulation	NN
cord-015910-d9gxew91	497	22	in	in	IN
cord-015910-d9gxew91	497	23	the	the	DT
cord-015910-d9gxew91	497	24	level	level	NN
cord-015910-d9gxew91	497	25	of	of	IN
cord-015910-d9gxew91	497	26	inflammation	inflammation	NN
cord-015910-d9gxew91	497	27	in	in	IN
cord-015910-d9gxew91	497	28	the	the	DT
cord-015910-d9gxew91	497	29	elderly	elderly	JJ
cord-015910-d9gxew91	497	30	,	,	,
cord-015910-d9gxew91	497	31	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	497	32	therapy	therapy	NN
cord-015910-d9gxew91	497	33	could	could	MD
cord-015910-d9gxew91	497	34	produce	produce	VB
cord-015910-d9gxew91	497	35	beneficial	beneficial	JJ
cord-015910-d9gxew91	497	36	effects	effect	NNS
cord-015910-d9gxew91	497	37	.	.	.
cord-015910-d9gxew91	498	1	The	the	DT
cord-015910-d9gxew91	498	2	effects	effect	NNS
cord-015910-d9gxew91	498	3	would	would	MD
cord-015910-d9gxew91	498	4	be	be	VB
cord-015910-d9gxew91	498	5	seen	see	VBN
cord-015910-d9gxew91	498	6	in	in	IN
cord-015910-d9gxew91	498	7	a	a	DT
cord-015910-d9gxew91	498	8	decrease	decrease	NN
cord-015910-d9gxew91	498	9	in	in	IN
cord-015910-d9gxew91	498	10	oxidant	oxidant	JJ
cord-015910-d9gxew91	498	11	damage	damage	NN
cord-015910-d9gxew91	498	12	,	,	,
cord-015910-d9gxew91	498	13	downregulation	downregulation	NN
cord-015910-d9gxew91	498	14	of	of	IN
cord-015910-d9gxew91	498	15	inflammation	inflammation	NN
cord-015910-d9gxew91	498	16	,	,	,
cord-015910-d9gxew91	498	17	and	and	CC
cord-015910-d9gxew91	498	18	,	,	,
cord-015910-d9gxew91	498	19	because	because	IN
cord-015910-d9gxew91	498	20	of	of	IN
cord-015910-d9gxew91	498	21	the	the	DT
cord-015910-d9gxew91	498	22	inverse	inverse	JJ
cord-015910-d9gxew91	498	23	link	link	NN
cord-015910-d9gxew91	498	24	between	between	IN
cord-015910-d9gxew91	498	25	inflammation	inflammation	NN
cord-015910-d9gxew91	498	26	and	and	CC
cord-015910-d9gxew91	498	27	immune	immune	JJ
cord-015910-d9gxew91	498	28	function	function	NN
cord-015910-d9gxew91	498	29	,	,	,
cord-015910-d9gxew91	498	30	an	an	DT
cord-015910-d9gxew91	498	31	improvement	improvement	NN
cord-015910-d9gxew91	498	32	in	in	IN
cord-015910-d9gxew91	498	33	T	t	NN
cord-015910-d9gxew91	498	34	-	-	HYPH
cord-015910-d9gxew91	498	35	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	498	36	function	function	NN
cord-015910-d9gxew91	498	37	.	.	.
cord-015910-d9gxew91	499	1	Meydani	Meydani	NNP
cord-015910-d9gxew91	499	2	,	,	,
cord-015910-d9gxew91	499	3	Meydani	Meydani	NNP
cord-015910-d9gxew91	499	4	,	,	,
cord-015910-d9gxew91	499	5	&	&	CC
cord-015910-d9gxew91	499	6	Verdon	Verdon	NNP
cord-015910-d9gxew91	499	7	(	(	-LRB-
cord-015910-d9gxew91	499	8	1986	1986	CD
cord-015910-d9gxew91	499	9	)	)	-RRB-
cord-015910-d9gxew91	499	10	reported	report	VBD
cord-015910-d9gxew91	499	11	that	that	IN
cord-015910-d9gxew91	499	12	supplementation	supplementation	NN
cord-015910-d9gxew91	499	13	of	of	IN
cord-015910-d9gxew91	499	14	aged	aged	JJ
cord-015910-d9gxew91	499	15	mice	mouse	NNS
cord-015910-d9gxew91	499	16	(	(	-LRB-
cord-015910-d9gxew91	499	17	24	24	CD
cord-015910-d9gxew91	499	18	mo	mo	NNP
cord-015910-d9gxew91	499	19	old	old	JJ
cord-015910-d9gxew91	499	20	)	)	-RRB-
cord-015910-d9gxew91	499	21	with	with	IN
cord-015910-d9gxew91	499	22	dietary	dietary	JJ
cord-015910-d9gxew91	499	23	vitamin	vitamin	NN
cord-015910-d9gxew91	499	24	E	e	NN
cord-015910-d9gxew91	499	25	(	(	-LRB-
cord-015910-d9gxew91	499	26	500	500	CD
cord-015910-d9gxew91	499	27	ppm	ppm	NN
cord-015910-d9gxew91	499	28	)	)	-RRB-
cord-015910-d9gxew91	499	29	improved	improve	VBD
cord-015910-d9gxew91	499	30	several	several	JJ
cord-015910-d9gxew91	499	31	indices	index	NNS
cord-015910-d9gxew91	499	32	of	of	IN
cord-015910-d9gxew91	499	33	the	the	DT
cord-015910-d9gxew91	499	34	immune	immune	JJ
cord-015910-d9gxew91	499	35	system	system	NN
cord-015910-d9gxew91	499	36	to	to	IN
cord-015910-d9gxew91	499	37	levels	level	NNS
cord-015910-d9gxew91	499	38	comparable	comparable	JJ
cord-015910-d9gxew91	499	39	to	to	IN
cord-015910-d9gxew91	499	40	those	those	DT
cord-015910-d9gxew91	499	41	seen	see	VBN
cord-015910-d9gxew91	499	42	in	in	IN
cord-015910-d9gxew91	499	43	young	young	JJ
cord-015910-d9gxew91	499	44	animals	animal	NNS
cord-015910-d9gxew91	499	45	.	.	.
cord-015910-d9gxew91	500	1	Supplementation	supplementation	NN
cord-015910-d9gxew91	500	2	of	of	IN
cord-015910-d9gxew91	500	3	aged	aged	JJ
cord-015910-d9gxew91	500	4	mice	mouse	NNS
cord-015910-d9gxew91	500	5	with	with	IN
cord-015910-d9gxew91	500	6	this	this	DT
cord-015910-d9gxew91	500	7	vitamin	vitamin	NN
cord-015910-d9gxew91	500	8	also	also	RB
cord-015910-d9gxew91	500	9	increased	increase	VBD
cord-015910-d9gxew91	500	10	clearance	clearance	NN
cord-015910-d9gxew91	500	11	of	of	IN
cord-015910-d9gxew91	500	12	influenza	influenza	NN
cord-015910-d9gxew91	500	13	virus	virus	NN
cord-015910-d9gxew91	500	14	from	from	IN
cord-015910-d9gxew91	500	15	the	the	DT
cord-015910-d9gxew91	500	16	lung	lung	NN
cord-015910-d9gxew91	500	17	to	to	IN
cord-015910-d9gxew91	500	18	that	that	DT
cord-015910-d9gxew91	500	19	observed	observe	VBN
cord-015910-d9gxew91	500	20	in	in	IN
cord-015910-d9gxew91	500	21	animals	animal	NNS
cord-015910-d9gxew91	500	22	supplemented	supplement	VBN
cord-015910-d9gxew91	500	23	with	with	IN
cord-015910-d9gxew91	500	24	other	other	JJ
cord-015910-d9gxew91	500	25	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	500	26	such	such	JJ
cord-015910-d9gxew91	500	27	as	as	IN
cord-015910-d9gxew91	500	28	melathonine	melathonine	NN
cord-015910-d9gxew91	500	29	,	,	,
cord-015910-d9gxew91	500	30	GSH	GSH	NNP
cord-015910-d9gxew91	500	31	,	,	,
cord-015910-d9gxew91	500	32	or	or	CC
cord-015910-d9gxew91	500	33	strawberry	strawberry	NN
cord-015910-d9gxew91	500	34	extract	extract	NN
cord-015910-d9gxew91	500	35	,	,	,
cord-015910-d9gxew91	500	36	which	which	WDT
cord-015910-d9gxew91	500	37	contains	contain	VBZ
cord-015910-d9gxew91	500	38	a	a	DT
cord-015910-d9gxew91	500	39	high	high	JJ
cord-015910-d9gxew91	500	40	level	level	NN
cord-015910-d9gxew91	500	41	of	of	IN
cord-015910-d9gxew91	500	42	flavonoids	flavonoid	NNS
cord-015910-d9gxew91	500	43	with	with	IN
cord-015910-d9gxew91	500	44	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	500	45	activity	activity	NN
cord-015910-d9gxew91	500	46	.	.	.
cord-015910-d9gxew91	501	1	In	in	IN
cord-015910-d9gxew91	501	2	a	a	DT
cord-015910-d9gxew91	501	3	double	double	JJ
cord-015910-d9gxew91	501	4	-	-	HYPH
cord-015910-d9gxew91	501	5	blind	blind	JJ
cord-015910-d9gxew91	501	6	,	,	,
cord-015910-d9gxew91	501	7	placebo	placebo	NN
cord-015910-d9gxew91	501	8	-	-	HYPH
cord-015910-d9gxew91	501	9	controlled	control	VBN
cord-015910-d9gxew91	501	10	study	study	NN
cord-015910-d9gxew91	501	11	,	,	,
cord-015910-d9gxew91	501	12	Meydani	Meydani	NNP
cord-015910-d9gxew91	501	13	and	and	CC
cord-015910-d9gxew91	501	14	colleagues	colleague	NNS
cord-015910-d9gxew91	501	15	(	(	-LRB-
cord-015910-d9gxew91	501	16	Meydani	Meydani	NNP
cord-015910-d9gxew91	501	17	,	,	,
cord-015910-d9gxew91	501	18	Barklund	Barklund	NNP
cord-015910-d9gxew91	501	19	,	,	,
cord-015910-d9gxew91	501	20	&	&	CC
cord-015910-d9gxew91	501	21	Lui	Lui	NNP
cord-015910-d9gxew91	501	22	,	,	,
cord-015910-d9gxew91	501	23	1990	1990	CD
cord-015910-d9gxew91	501	24	;	;	:
cord-015910-d9gxew91	501	25	Meydani	Meydani	NNP
cord-015910-d9gxew91	501	26	et	et	NNP
cord-015910-d9gxew91	501	27	al	al	NNP
cord-015910-d9gxew91	501	28	.	.	NNP
cord-015910-d9gxew91	501	29	,	,	,
cord-015910-d9gxew91	501	30	1997	1997	CD
cord-015910-d9gxew91	501	31	)	)	-RRB-
cord-015910-d9gxew91	501	32	also	also	RB
cord-015910-d9gxew91	501	33	reported	report	VBD
cord-015910-d9gxew91	501	34	that	that	IN
cord-015910-d9gxew91	501	35	supplementation	supplementation	NN
cord-015910-d9gxew91	501	36	of	of	IN
cord-015910-d9gxew91	501	37	elderly	elderly	JJ
cord-015910-d9gxew91	501	38	subjects	subject	NNS
cord-015910-d9gxew91	501	39	with	with	IN
cord-015910-d9gxew91	501	40	vitamin	vitamin	NN
cord-015910-d9gxew91	501	41	E	e	NN
cord-015910-d9gxew91	501	42	for	for	IN
cord-015910-d9gxew91	501	43	a	a	DT
cord-015910-d9gxew91	501	44	short	short	JJ
cord-015910-d9gxew91	501	45	(	(	-LRB-
cord-015910-d9gxew91	501	46	1	1	CD
cord-015910-d9gxew91	501	47	mo	mo	NN
cord-015910-d9gxew91	501	48	)	)	-RRB-
cord-015910-d9gxew91	501	49	or	or	CC
cord-015910-d9gxew91	501	50	long	long	JJ
cord-015910-d9gxew91	501	51	(	(	-LRB-
cord-015910-d9gxew91	501	52	4.5	4.5	CD
cord-015910-d9gxew91	501	53	too	too	RB
cord-015910-d9gxew91	501	54	)	)	-RRB-
cord-015910-d9gxew91	501	55	period	period	NN
cord-015910-d9gxew91	501	56	of	of	IN
cord-015910-d9gxew91	501	57	time	time	NN
cord-015910-d9gxew91	501	58	also	also	RB
cord-015910-d9gxew91	501	59	improved	improve	VBD
cord-015910-d9gxew91	501	60	several	several	JJ
cord-015910-d9gxew91	501	61	in	in	IN
cord-015910-d9gxew91	501	62	vitro	vitro	FW
cord-015910-d9gxew91	501	63	and	and	CC
cord-015910-d9gxew91	501	64	in	in	IN
cord-015910-d9gxew91	501	65	vivo	vivo	NNP
cord-015910-d9gxew91	501	66	indices	index	NNS
cord-015910-d9gxew91	501	67	of	of	IN
cord-015910-d9gxew91	501	68	immune	immune	JJ
cord-015910-d9gxew91	501	69	response	response	NN
cord-015910-d9gxew91	501	70	.	.	.
cord-015910-d9gxew91	502	1	The	the	DT
cord-015910-d9gxew91	502	2	optimal	optimal	JJ
cord-015910-d9gxew91	502	3	immune	immune	JJ
cord-015910-d9gxew91	502	4	response	response	NN
cord-015910-d9gxew91	502	5	was	be	VBD
cord-015910-d9gxew91	502	6	observed	observe	VBN
cord-015910-d9gxew91	502	7	with	with	IN
cord-015910-d9gxew91	502	8	200	200	CD
cord-015910-d9gxew91	502	9	IU	IU	NNP
cord-015910-d9gxew91	502	10	of	of	IN
cord-015910-d9gxew91	502	11	vitamin	vitamin	NN
cord-015910-d9gxew91	502	12	E	e	NN
cord-015910-d9gxew91	502	13	per	per	IN
cord-015910-d9gxew91	502	14	day	day	NN
cord-015910-d9gxew91	502	15	in	in	IN
cord-015910-d9gxew91	502	16	the	the	DT
cord-015910-d9gxew91	502	17	long	long	JJ
cord-015910-d9gxew91	502	18	-	-	HYPH
cord-015910-d9gxew91	502	19	term	term	NN
cord-015910-d9gxew91	502	20	study	study	NN
cord-015910-d9gxew91	502	21	.	.	.
cord-015910-d9gxew91	503	1	It	-PRON-	PRP
cord-015910-d9gxew91	503	2	is	be	VBZ
cord-015910-d9gxew91	503	3	worth	worth	JJ
cord-015910-d9gxew91	503	4	noting	note	VBG
cord-015910-d9gxew91	503	5	that	that	IN
cord-015910-d9gxew91	503	6	this	this	DT
cord-015910-d9gxew91	503	7	level	level	NN
cord-015910-d9gxew91	503	8	of	of	IN
cord-015910-d9gxew91	503	9	vitamin	vitamin	NN
cord-015910-d9gxew91	503	10	E	e	NN
cord-015910-d9gxew91	503	11	has	have	VBZ
cord-015910-d9gxew91	503	12	also	also	RB
cord-015910-d9gxew91	503	13	been	be	VBN
cord-015910-d9gxew91	503	14	reported	report	VBN
cord-015910-d9gxew91	503	15	to	to	TO
cord-015910-d9gxew91	503	16	be	be	VB
cord-015910-d9gxew91	503	17	the	the	DT
cord-015910-d9gxew91	503	18	optimal	optimal	JJ
cord-015910-d9gxew91	503	19	level	level	NN
cord-015910-d9gxew91	503	20	for	for	IN
cord-015910-d9gxew91	503	21	reducing	reduce	VBG
cord-015910-d9gxew91	503	22	plasma	plasma	NN
cord-015910-d9gxew91	503	23	F2-isoprostane	F2-isoprostane	NNP
cord-015910-d9gxew91	503	24	,	,	,
cord-015910-d9gxew91	503	25	a	a	DT
cord-015910-d9gxew91	503	26	reliable	reliable	JJ
cord-015910-d9gxew91	503	27	index	index	NN
cord-015910-d9gxew91	503	28	of	of	IN
cord-015910-d9gxew91	503	29	lipid	lipid	NN
cord-015910-d9gxew91	503	30	peroxidation	peroxidation	NN
cord-015910-d9gxew91	503	31	(	(	-LRB-
cord-015910-d9gxew91	503	32	Dillon	Dillon	NNP
cord-015910-d9gxew91	503	33	,	,	,
cord-015910-d9gxew91	503	34	Vita	Vita	NNP
cord-015910-d9gxew91	503	35	,	,	,
cord-015910-d9gxew91	503	36	&	&	CC
cord-015910-d9gxew91	503	37	Leeuwenburgh	Leeuwenburgh	NNP
cord-015910-d9gxew91	503	38	,	,	,
cord-015910-d9gxew91	503	39	1998	1998	CD
cord-015910-d9gxew91	503	40	)	)	-RRB-
cord-015910-d9gxew91	503	41	.	.	.
cord-015910-d9gxew91	504	1	Improving	improve	VBG
cord-015910-d9gxew91	504	2	the	the	DT
cord-015910-d9gxew91	504	3	immune	immune	JJ
cord-015910-d9gxew91	504	4	response	response	NN
cord-015910-d9gxew91	504	5	in	in	IN
cord-015910-d9gxew91	504	6	the	the	DT
cord-015910-d9gxew91	504	7	elderly	elderly	JJ
cord-015910-d9gxew91	504	8	may	may	MD
cord-015910-d9gxew91	504	9	result	result	VB
cord-015910-d9gxew91	504	10	in	in	IN
cord-015910-d9gxew91	504	11	a	a	DT
cord-015910-d9gxew91	504	12	lower	low	JJR
cord-015910-d9gxew91	504	13	incidence	incidence	NN
cord-015910-d9gxew91	504	14	of	of	IN
cord-015910-d9gxew91	504	15	infections	infection	NNS
cord-015910-d9gxew91	504	16	,	,	,
cord-015910-d9gxew91	504	17	which	which	WDT
cord-015910-d9gxew91	504	18	are	be	VBP
cord-015910-d9gxew91	504	19	prevalent	prevalent	JJ
cord-015910-d9gxew91	504	20	among	among	IN
cord-015910-d9gxew91	504	21	the	the	DT
cord-015910-d9gxew91	504	22	elderly	elderly	JJ
cord-015910-d9gxew91	504	23	,	,	,
cord-015910-d9gxew91	504	24	and	and	CC
cord-015910-d9gxew91	504	25	thus	thus	RB
cord-015910-d9gxew91	504	26	may	may	MD
cord-015910-d9gxew91	504	27	contribute	contribute	VB
cord-015910-d9gxew91	504	28	to	to	IN
cord-015910-d9gxew91	504	29	a	a	DT
cord-015910-d9gxew91	504	30	longer	long	JJR
cord-015910-d9gxew91	504	31	and	and	CC
cord-015910-d9gxew91	504	32	healthier	healthy	JJR
cord-015910-d9gxew91	504	33	life	life	NN
cord-015910-d9gxew91	504	34	.	.	.
cord-015910-d9gxew91	505	1	Many	many	JJ
cord-015910-d9gxew91	505	2	observational	observational	JJ
cord-015910-d9gxew91	505	3	and	and	CC
cord-015910-d9gxew91	505	4	clinical	clinical	JJ
cord-015910-d9gxew91	505	5	trials	trial	NNS
cord-015910-d9gxew91	505	6	have	have	VBP
cord-015910-d9gxew91	505	7	also	also	RB
cord-015910-d9gxew91	505	8	indicated	indicate	VBN
cord-015910-d9gxew91	505	9	that	that	IN
cord-015910-d9gxew91	505	10	a	a	DT
cord-015910-d9gxew91	505	11	high	high	JJ
cord-015910-d9gxew91	505	12	intake	intake	NN
cord-015910-d9gxew91	505	13	or	or	CC
cord-015910-d9gxew91	505	14	high	high	JJ
cord-015910-d9gxew91	505	15	plasma	plasma	NN
cord-015910-d9gxew91	505	16	level	level	NN
cord-015910-d9gxew91	505	17	of	of	IN
cord-015910-d9gxew91	505	18	this	this	DT
cord-015910-d9gxew91	505	19	vitamin	vitamin	NN
cord-015910-d9gxew91	505	20	is	be	VBZ
cord-015910-d9gxew91	505	21	associated	associate	VBN
cord-015910-d9gxew91	505	22	with	with	IN
cord-015910-d9gxew91	505	23	a	a	DT
cord-015910-d9gxew91	505	24	low	low	JJ
cord-015910-d9gxew91	505	25	risk	risk	NN
cord-015910-d9gxew91	505	26	of	of	IN
cord-015910-d9gxew91	505	27	cardiovascular	cardiovascular	JJ
cord-015910-d9gxew91	505	28	disease	disease	NN
cord-015910-d9gxew91	505	29	.	.	.
cord-015910-d9gxew91	506	1	The	the	DT
cord-015910-d9gxew91	506	2	vitamin	vitamin	NN
cord-015910-d9gxew91	506	3	may	may	MD
cord-015910-d9gxew91	506	4	be	be	VB
cord-015910-d9gxew91	506	5	operating	operate	VBG
cord-015910-d9gxew91	506	6	at	at	IN
cord-015910-d9gxew91	506	7	two	two	CD
cord-015910-d9gxew91	506	8	levels	level	NNS
cord-015910-d9gxew91	506	9	;	;	:
cord-015910-d9gxew91	506	10	first	first	RB
cord-015910-d9gxew91	506	11	,	,	,
cord-015910-d9gxew91	506	12	by	by	IN
cord-015910-d9gxew91	506	13	protecting	protect	VBG
cord-015910-d9gxew91	506	14	LDL	ldl	NN
cord-015910-d9gxew91	506	15	from	from	IN
cord-015910-d9gxew91	506	16	peroxidation	peroxidation	NN
cord-015910-d9gxew91	506	17	,	,	,
cord-015910-d9gxew91	506	18	thereby	thereby	RB
cord-015910-d9gxew91	506	19	reducing	reduce	VBG
cord-015910-d9gxew91	506	20	its	-PRON-	PRP$
cord-015910-d9gxew91	506	21	atherogenicity	atherogenicity	NN
cord-015910-d9gxew91	506	22	,	,	,
cord-015910-d9gxew91	506	23	and	and	CC
cord-015910-d9gxew91	506	24	second	second	RB
cord-015910-d9gxew91	506	25	,	,	,
cord-015910-d9gxew91	506	26	by	by	IN
cord-015910-d9gxew91	506	27	lowering	lower	VBG
cord-015910-d9gxew91	506	28	the	the	DT
cord-015910-d9gxew91	506	29	level	level	NN
cord-015910-d9gxew91	506	30	of	of	IN
cord-015910-d9gxew91	506	31	chronic	chronic	JJ
cord-015910-d9gxew91	506	32	inflammation	inflammation	NN
cord-015910-d9gxew91	506	33	by	by	IN
cord-015910-d9gxew91	506	34	downregulation	downregulation	NN
cord-015910-d9gxew91	506	35	of	of	IN
cord-015910-d9gxew91	506	36	NF	nf	NN
cord-015910-d9gxew91	506	37	-	-	HYPH
cord-015910-d9gxew91	506	38	r	r	NNP
cord-015910-d9gxew91	506	39	,	,	,
cord-015910-d9gxew91	506	40	B.	B.	NNP
cord-015910-d9gxew91	506	41	A	a	DT
cord-015910-d9gxew91	506	42	reduction	reduction	NN
cord-015910-d9gxew91	506	43	in	in	IN
cord-015910-d9gxew91	506	44	platelet	platelet	NN
cord-015910-d9gxew91	506	45	aggregability	aggregability	NN
cord-015910-d9gxew91	506	46	may	may	MD
cord-015910-d9gxew91	506	47	also	also	RB
cord-015910-d9gxew91	506	48	arise	arise	VB
cord-015910-d9gxew91	506	49	out	out	IN
cord-015910-d9gxew91	506	50	of	of	IN
cord-015910-d9gxew91	506	51	this	this	DT
cord-015910-d9gxew91	506	52	action	action	NN
cord-015910-d9gxew91	506	53	(	(	-LRB-
cord-015910-d9gxew91	506	54	Huang	Huang	NNP
cord-015910-d9gxew91	506	55	et	et	NNP
cord-015910-d9gxew91	506	56	al	al	NNP
cord-015910-d9gxew91	506	57	.	.	NNP
cord-015910-d9gxew91	506	58	,	,	,
cord-015910-d9gxew91	506	59	2001	2001	CD
cord-015910-d9gxew91	506	60	;	;	:
cord-015910-d9gxew91	506	61	Tanus	Tanus	NNP
cord-015910-d9gxew91	506	62	-	-	HYPH
cord-015910-d9gxew91	506	63	Santos	Santos	NNP
cord-015910-d9gxew91	506	64	et	et	FW
cord-015910-d9gxew91	506	65	al	al	NNP
cord-015910-d9gxew91	506	66	.	.	NNP
cord-015910-d9gxew91	506	67	,	,	,
cord-015910-d9gxew91	506	68	2002	2002	CD
cord-015910-d9gxew91	506	69	)	)	-RRB-
cord-015910-d9gxew91	506	70	.	.	.
cord-015910-d9gxew91	507	1	Indeed	indeed	RB
cord-015910-d9gxew91	507	2	,	,	,
cord-015910-d9gxew91	507	3	several	several	JJ
cord-015910-d9gxew91	507	4	lines	line	NNS
cord-015910-d9gxew91	507	5	of	of	IN
cord-015910-d9gxew91	507	6	evidence	evidence	NN
cord-015910-d9gxew91	507	7	indicated	indicate	VBD
cord-015910-d9gxew91	507	8	that	that	IN
cord-015910-d9gxew91	507	9	supplements	supplement	NNS
cord-015910-d9gxew91	507	10	of	of	IN
cord-015910-d9gxew91	507	11	vitamin	vitamin	NN
cord-015910-d9gxew91	507	12	E	e	NN
cord-015910-d9gxew91	507	13	may	may	MD
cord-015910-d9gxew91	507	14	prevent	prevent	VB
cord-015910-d9gxew91	507	15	cardiovascular	cardiovascular	JJ
cord-015910-d9gxew91	507	16	disease	disease	NN
cord-015910-d9gxew91	507	17	by	by	IN
cord-015910-d9gxew91	507	18	reducing	reduce	VBG
cord-015910-d9gxew91	507	19	the	the	DT
cord-015910-d9gxew91	507	20	susceptibility	susceptibility	NN
cord-015910-d9gxew91	507	21	of	of	IN
cord-015910-d9gxew91	507	22	LDLs	LDLs	NNP
cord-015910-d9gxew91	507	23	to	to	IN
cord-015910-d9gxew91	507	24	oxidation	oxidation	NN
cord-015910-d9gxew91	507	25	(	(	-LRB-
cord-015910-d9gxew91	507	26	Jailal	Jailal	NNP
cord-015910-d9gxew91	507	27	,	,	,
cord-015910-d9gxew91	507	28	Fuller	Fuller	NNP
cord-015910-d9gxew91	507	29	,	,	,
cord-015910-d9gxew91	507	30	&	&	CC
cord-015910-d9gxew91	507	31	Huet	Huet	NNP
cord-015910-d9gxew91	507	32	,	,	,
cord-015910-d9gxew91	507	33	1995	1995	CD
cord-015910-d9gxew91	507	34	)	)	-RRB-
cord-015910-d9gxew91	507	35	,	,	,
cord-015910-d9gxew91	507	36	reducing	reduce	VBG
cord-015910-d9gxew91	507	37	the	the	DT
cord-015910-d9gxew91	507	38	expression	expression	NN
cord-015910-d9gxew91	507	39	of	of	IN
cord-015910-d9gxew91	507	40	chemokines	chemokine	NNS
cord-015910-d9gxew91	507	41	,	,	,
cord-015910-d9gxew91	507	42	adhesion	adhesion	NN
cord-015910-d9gxew91	507	43	molecule	molecule	NN
cord-015910-d9gxew91	507	44	expression	expression	NN
cord-015910-d9gxew91	507	45	,	,	,
cord-015910-d9gxew91	507	46	and	and	CC
cord-015910-d9gxew91	507	47	monocyte	monocyte	NNP
cord-015910-d9gxew91	507	48	adhesion	adhesion	NN
cord-015910-d9gxew91	507	49	(	(	-LRB-
cord-015910-d9gxew91	507	50	Wu	Wu	NNP
cord-015910-d9gxew91	507	51	,	,	,
cord-015910-d9gxew91	507	52	Koga	Koga	NNP
cord-015910-d9gxew91	507	53	,	,	,
cord-015910-d9gxew91	507	54	Martin	Martin	NNP
cord-015910-d9gxew91	507	55	,	,	,
cord-015910-d9gxew91	507	56	&	&	CC
cord-015910-d9gxew91	507	57	Meydani	Meydani	NNP
cord-015910-d9gxew91	507	58	,	,	,
cord-015910-d9gxew91	507	59	1999	1999	CD
cord-015910-d9gxew91	507	60	)	)	-RRB-
cord-015910-d9gxew91	507	61	,	,	,
cord-015910-d9gxew91	507	62	decreasing	decrease	VBG
cord-015910-d9gxew91	507	63	smooth	smooth	JJ
cord-015910-d9gxew91	507	64	muscle	muscle	NN
cord-015910-d9gxew91	507	65	proliferation	proliferation	NN
cord-015910-d9gxew91	507	66	(	(	-LRB-
cord-015910-d9gxew91	507	67	Azzi	Azzi	NNP
cord-015910-d9gxew91	507	68	,	,	,
cord-015910-d9gxew91	507	69	Boscoboinik	Boscoboinik	NNP
cord-015910-d9gxew91	507	70	,	,	,
cord-015910-d9gxew91	507	71	&	&	CC
cord-015910-d9gxew91	507	72	Marilley	Marilley	NNP
cord-015910-d9gxew91	507	73	,	,	,
cord-015910-d9gxew91	507	74	1995	1995	CD
cord-015910-d9gxew91	507	75	)	)	-RRB-
cord-015910-d9gxew91	507	76	,	,	,
cord-015910-d9gxew91	507	77	and	and	CC
cord-015910-d9gxew91	507	78	decreasing	decrease	VBG
cord-015910-d9gxew91	507	79	platelet	platelet	NN
cord-015910-d9gxew91	507	80	aggregation	aggregation	NN
cord-015910-d9gxew91	507	81	(	(	-LRB-
cord-015910-d9gxew91	507	82	Steiner	Steiner	NNP
cord-015910-d9gxew91	507	83	1999	1999	CD
cord-015910-d9gxew91	507	84	)	)	-RRB-
cord-015910-d9gxew91	507	85	.	.	.
cord-015910-d9gxew91	508	1	Another	another	DT
cord-015910-d9gxew91	508	2	anti	anti	JJ
cord-015910-d9gxew91	508	3	-	-	JJ
cord-015910-d9gxew91	508	4	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	508	5	approach	approach	NN
cord-015910-d9gxew91	508	6	using	use	VBG
cord-015910-d9gxew91	508	7	nutrients	nutrient	NNS
cord-015910-d9gxew91	508	8	would	would	MD
cord-015910-d9gxew91	508	9	be	be	VB
cord-015910-d9gxew91	508	10	to	to	TO
cord-015910-d9gxew91	508	11	supplement	supplement	VB
cord-015910-d9gxew91	508	12	diets	diet	NNS
cord-015910-d9gxew91	508	13	of	of	IN
cord-015910-d9gxew91	508	14	the	the	DT
cord-015910-d9gxew91	508	15	elderly	elderly	JJ
cord-015910-d9gxew91	508	16	with	with	IN
cord-015910-d9gxew91	508	17	n-3	n-3	NN
cord-015910-d9gxew91	508	18	PUFAs	pufa	NNS
cord-015910-d9gxew91	508	19	.	.	.
cord-015910-d9gxew91	509	1	Supplementation	supplementation	NN
cord-015910-d9gxew91	509	2	with	with	IN
cord-015910-d9gxew91	509	3	n-3	n-3	NN
cord-015910-d9gxew91	509	4	PUFAs	pufa	NNS
cord-015910-d9gxew91	509	5	from	from	IN
cord-015910-d9gxew91	509	6	fish	fish	NN
cord-015910-d9gxew91	509	7	oil	oil	NN
cord-015910-d9gxew91	509	8	,	,	,
cord-015910-d9gxew91	509	9	however	however	RB
cord-015910-d9gxew91	509	10	,	,	,
cord-015910-d9gxew91	509	11	has	have	VBZ
cord-015910-d9gxew91	509	12	been	be	VBN
cord-015910-d9gxew91	509	13	reported	report	VBN
cord-015910-d9gxew91	509	14	to	to	TO
cord-015910-d9gxew91	509	15	suppress	suppress	VB
cord-015910-d9gxew91	509	16	the	the	DT
cord-015910-d9gxew91	509	17	immune	immune	JJ
cord-015910-d9gxew91	509	18	response	response	NN
cord-015910-d9gxew91	509	19	(	(	-LRB-
cord-015910-d9gxew91	509	20	Meydani	Meydani	NNP
cord-015910-d9gxew91	509	21	,	,	,
cord-015910-d9gxew91	509	22	Endres	Endres	NNP
cord-015910-d9gxew91	509	23	,	,	,
cord-015910-d9gxew91	509	24	&	&	CC
cord-015910-d9gxew91	509	25	Woods	Woods	NNP
cord-015910-d9gxew91	509	26	,	,	,
cord-015910-d9gxew91	509	27	1991	1991	CD
cord-015910-d9gxew91	509	28	;	;	:
cord-015910-d9gxew91	509	29	Meydani	Meydani	NNP
cord-015910-d9gxew91	509	30	,	,	,
cord-015910-d9gxew91	509	31	1993	1993	CD
cord-015910-d9gxew91	509	32	)	)	-RRB-
cord-015910-d9gxew91	509	33	,	,	,
cord-015910-d9gxew91	509	34	which	which	WDT
cord-015910-d9gxew91	509	35	hampers	hamper	VBZ
cord-015910-d9gxew91	509	36	enthusiasm	enthusiasm	NN
cord-015910-d9gxew91	509	37	for	for	IN
cord-015910-d9gxew91	509	38	the	the	DT
cord-015910-d9gxew91	509	39	use	use	NN
cord-015910-d9gxew91	509	40	of	of	IN
cord-015910-d9gxew91	509	41	n-3	n-3	NN
cord-015910-d9gxew91	509	42	PUFAs	pufa	NNS
cord-015910-d9gxew91	509	43	for	for	IN
cord-015910-d9gxew91	509	44	their	-PRON-	PRP$
cord-015910-d9gxew91	509	45	benefits	benefit	NNS
cord-015910-d9gxew91	509	46	in	in	IN
cord-015910-d9gxew91	509	47	CVD	CVD	NNP
cord-015910-d9gxew91	509	48	.	.	.
cord-015910-d9gxew91	510	1	However	however	RB
cord-015910-d9gxew91	510	2	,	,	,
cord-015910-d9gxew91	510	3	the	the	DT
cord-015910-d9gxew91	510	4	latter	latter	JJ
cord-015910-d9gxew91	510	5	concern	concern	NN
cord-015910-d9gxew91	510	6	could	could	MD
cord-015910-d9gxew91	510	7	be	be	VB
cord-015910-d9gxew91	510	8	addressed	address	VBN
cord-015910-d9gxew91	510	9	by	by	IN
cord-015910-d9gxew91	510	10	including	include	VBG
cord-015910-d9gxew91	510	11	a	a	DT
cord-015910-d9gxew91	510	12	vitamin	vitamin	NN
cord-015910-d9gxew91	510	13	E	e	NN
cord-015910-d9gxew91	510	14	supplement	supplement	NN
cord-015910-d9gxew91	510	15	along	along	IN
cord-015910-d9gxew91	510	16	with	with	IN
cord-015910-d9gxew91	510	17	fish	fish	NN
cord-015910-d9gxew91	510	18	oil	oil	NN
cord-015910-d9gxew91	510	19	supplements	supplement	NNS
cord-015910-d9gxew91	510	20	.	.	.
cord-015910-d9gxew91	511	1	In	in	IN
cord-015910-d9gxew91	511	2	a	a	DT
cord-015910-d9gxew91	511	3	recent	recent	JJ
cord-015910-d9gxew91	511	4	study	study	NN
cord-015910-d9gxew91	511	5	it	-PRON-	PRP
cord-015910-d9gxew91	511	6	was	be	VBD
cord-015910-d9gxew91	511	7	found	find	VBN
cord-015910-d9gxew91	511	8	that	that	IN
cord-015910-d9gxew91	511	9	supplementing	supplement	VBG
cord-015910-d9gxew91	511	10	elderly	elderly	JJ
cord-015910-d9gxew91	511	11	persons	person	NNS
cord-015910-d9gxew91	511	12	with	with	IN
cord-015910-d9gxew91	511	13	(	(	-LRB-
cord-015910-d9gxew91	511	14	n-3	n-3	NN
cord-015910-d9gxew91	511	15	)	)	-RRB-
cord-015910-d9gxew91	511	16	fatty	fatty	JJ
cord-015910-d9gxew91	511	17	acids	acid	NNS
cord-015910-d9gxew91	511	18	of	of	IN
cord-015910-d9gxew91	511	19	fish	fish	NN
cord-015910-d9gxew91	511	20	oil	oil	NN
cord-015910-d9gxew91	511	21	in	in	IN
cord-015910-d9gxew91	511	22	combination	combination	NN
cord-015910-d9gxew91	511	23	with	with	IN
cord-015910-d9gxew91	511	24	vitamin	vitamin	NN
cord-015910-d9gxew91	511	25	E	e	NN
cord-015910-d9gxew91	511	26	while	while	IN
cord-015910-d9gxew91	511	27	maintaining	maintain	VBG
cord-015910-d9gxew91	511	28	the	the	DT
cord-015910-d9gxew91	511	29	anti	anti	JJ
cord-015910-d9gxew91	511	30	-	-	JJ
cord-015910-d9gxew91	511	31	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	511	32	properties	property	NNS
cord-015910-d9gxew91	511	33	of	of	IN
cord-015910-d9gxew91	512	1	(	(	-LRB-
cord-015910-d9gxew91	512	2	n-3	n-3	NN
cord-015910-d9gxew91	512	3	)	)	-RRB-
cord-015910-d9gxew91	512	4	PUFAs	pufa	NNS
cord-015910-d9gxew91	512	5	did	do	VBD
cord-015910-d9gxew91	512	6	not	not	RB
cord-015910-d9gxew91	512	7	reduce	reduce	VB
cord-015910-d9gxew91	512	8	immune	immune	JJ
cord-015910-d9gxew91	512	9	indices	index	NNS
cord-015910-d9gxew91	512	10	in	in	IN
cord-015910-d9gxew91	512	11	the	the	DT
cord-015910-d9gxew91	512	12	elderly	elderly	JJ
cord-015910-d9gxew91	512	13	.	.	.
cord-015910-d9gxew91	513	1	Fish	fish	NN
cord-015910-d9gxew91	513	2	oil	oil	NN
cord-015910-d9gxew91	513	3	supplementation	supplementation	NN
cord-015910-d9gxew91	513	4	is	be	VBZ
cord-015910-d9gxew91	513	5	not	not	RB
cord-015910-d9gxew91	513	6	universally	universally	RB
cord-015910-d9gxew91	513	7	efficacious	efficacious	JJ
cord-015910-d9gxew91	513	8	in	in	IN
cord-015910-d9gxew91	513	9	the	the	DT
cord-015910-d9gxew91	513	10	treatment	treatment	NN
cord-015910-d9gxew91	513	11	of	of	IN
cord-015910-d9gxew91	513	12	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	513	13	disease	disease	NN
cord-015910-d9gxew91	513	14	(	(	-LRB-
cord-015910-d9gxew91	513	15	Grimble	Grimble	NNP
cord-015910-d9gxew91	513	16	,	,	,
cord-015910-d9gxew91	513	17	1998	1998	CD
cord-015910-d9gxew91	513	18	)	)	-RRB-
cord-015910-d9gxew91	513	19	.	.	.
cord-015910-d9gxew91	514	1	Rheumatoid	rheumatoid	JJ
cord-015910-d9gxew91	514	2	arthritis	arthritis	NN
cord-015910-d9gxew91	514	3	and	and	CC
cord-015910-d9gxew91	514	4	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	514	5	bowel	bowel	NN
cord-015910-d9gxew91	514	6	disease	disease	NN
cord-015910-d9gxew91	514	7	have	have	VBP
cord-015910-d9gxew91	514	8	been	be	VBN
cord-015910-d9gxew91	514	9	the	the	DT
cord-015910-d9gxew91	514	10	most	most	RBS
cord-015910-d9gxew91	514	11	successfully	successfully	RB
cord-015910-d9gxew91	514	12	treated	treat	VBN
cord-015910-d9gxew91	514	13	of	of	IN
cord-015910-d9gxew91	514	14	all	all	DT
cord-015910-d9gxew91	514	15	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	514	16	diseases	disease	NNS
cord-015910-d9gxew91	514	17	(	(	-LRB-
cord-015910-d9gxew91	514	18	Calder	Calder	NNP
cord-015910-d9gxew91	514	19	,	,	,
cord-015910-d9gxew91	514	20	1997	1997	CD
cord-015910-d9gxew91	514	21	)	)	-RRB-
cord-015910-d9gxew91	514	22	.	.	.
cord-015910-d9gxew91	515	1	The	the	DT
cord-015910-d9gxew91	515	2	antiinflammatory	antiinflammatory	JJ
cord-015910-d9gxew91	515	3	mechanism	mechanism	NN
cord-015910-d9gxew91	515	4	may	may	MD
cord-015910-d9gxew91	515	5	be	be	VB
cord-015910-d9gxew91	515	6	through	through	IN
cord-015910-d9gxew91	515	7	suppression	suppression	NN
cord-015910-d9gxew91	515	8	of	of	IN
cord-015910-d9gxew91	515	9	TNF	TNF	NNP
cord-015910-d9gxew91	515	10	-	-	HYPH
cord-015910-d9gxew91	515	11	tx	tx	NNP
cord-015910-d9gxew91	515	12	production	production	NN
cord-015910-d9gxew91	515	13	.	.	.
cord-015910-d9gxew91	516	1	Endres	Endres	NNP
cord-015910-d9gxew91	516	2	et	et	FW
cord-015910-d9gxew91	516	3	al	al	NNP
cord-015910-d9gxew91	516	4	.	.	.
cord-015910-d9gxew91	517	1	(	(	-LRB-
cord-015910-d9gxew91	517	2	1989	1989	CD
cord-015910-d9gxew91	517	3	)	)	-RRB-
cord-015910-d9gxew91	517	4	reported	report	VBD
cord-015910-d9gxew91	517	5	that	that	IN
cord-015910-d9gxew91	517	6	large	large	JJ
cord-015910-d9gxew91	517	7	doses	dose	NNS
cord-015910-d9gxew91	517	8	(	(	-LRB-
cord-015910-d9gxew91	517	9	15	15	CD
cord-015910-d9gxew91	517	10	g	g	NN
cord-015910-d9gxew91	517	11	/	/	SYM
cord-015910-d9gxew91	517	12	d	d	NN
cord-015910-d9gxew91	517	13	for	for	IN
cord-015910-d9gxew91	517	14	6	6	CD
cord-015910-d9gxew91	517	15	wk	wk	NNS
cord-015910-d9gxew91	517	16	)	)	-RRB-
cord-015910-d9gxew91	517	17	of	of	IN
cord-015910-d9gxew91	517	18	oil	oil	NN
cord-015910-d9gxew91	517	19	in	in	IN
cord-015910-d9gxew91	517	20	nine	nine	CD
cord-015910-d9gxew91	517	21	healthy	healthy	JJ
cord-015910-d9gxew91	517	22	volunteers	volunteer	NNS
cord-015910-d9gxew91	517	23	resulted	result	VBD
cord-015910-d9gxew91	517	24	in	in	IN
cord-015910-d9gxew91	517	25	a	a	DT
cord-015910-d9gxew91	517	26	small	small	JJ
cord-015910-d9gxew91	517	27	but	but	CC
cord-015910-d9gxew91	517	28	statistically	statistically	RB
cord-015910-d9gxew91	517	29	significant	significant	JJ
cord-015910-d9gxew91	517	30	reduction	reduction	NN
cord-015910-d9gxew91	517	31	in	in	IN
cord-015910-d9gxew91	517	32	TNF	TNF	NNP
cord-015910-d9gxew91	517	33	-	-	HYPH
cord-015910-d9gxew91	517	34	o~	o~	NNP
cord-015910-d9gxew91	517	35	and	and	CC
cord-015910-d9gxew91	517	36	IL-1	IL-1	NNP
cord-015910-d9gxew91	517	37	[	[	-LRB-
cord-015910-d9gxew91	517	38	3	3	CD
cord-015910-d9gxew91	517	39	production	production	NN
cord-015910-d9gxew91	517	40	from	from	IN
cord-015910-d9gxew91	517	41	PBMCs	pbmc	NNS
cord-015910-d9gxew91	517	42	.	.	.
cord-015910-d9gxew91	518	1	Subsequently	subsequently	RB
cord-015910-d9gxew91	518	2	,	,	,
cord-015910-d9gxew91	518	3	fewer	few	JJR
cord-015910-d9gxew91	518	4	than	than	IN
cord-015910-d9gxew91	518	5	half	half	NN
cord-015910-d9gxew91	518	6	of	of	IN
cord-015910-d9gxew91	518	7	11	11	CD
cord-015910-d9gxew91	518	8	similar	similar	JJ
cord-015910-d9gxew91	518	9	small	small	JJ
cord-015910-d9gxew91	518	10	intervention	intervention	NN
cord-015910-d9gxew91	518	11	studies	study	NNS
cord-015910-d9gxew91	518	12	were	be	VBD
cord-015910-d9gxew91	518	13	able	able	JJ
cord-015910-d9gxew91	518	14	to	to	TO
cord-015910-d9gxew91	518	15	demonstrate	demonstrate	VB
cord-015910-d9gxew91	518	16	a	a	DT
cord-015910-d9gxew91	518	17	statistically	statistically	RB
cord-015910-d9gxew91	518	18	significant	significant	JJ
cord-015910-d9gxew91	518	19	reduction	reduction	NN
cord-015910-d9gxew91	518	20	in	in	IN
cord-015910-d9gxew91	518	21	cytokine	cytokine	NN
cord-015910-d9gxew91	518	22	production	production	NN
cord-015910-d9gxew91	518	23	.	.	.
cord-015910-d9gxew91	519	1	To	to	TO
cord-015910-d9gxew91	519	2	understand	understand	VB
cord-015910-d9gxew91	519	3	the	the	DT
cord-015910-d9gxew91	519	4	differences	difference	NNS
cord-015910-d9gxew91	519	5	in	in	IN
cord-015910-d9gxew91	519	6	response	response	NN
cord-015910-d9gxew91	519	7	more	more	RBR
cord-015910-d9gxew91	519	8	closely	closely	RB
cord-015910-d9gxew91	519	9	,	,	,
cord-015910-d9gxew91	519	10	the	the	DT
cord-015910-d9gxew91	519	11	author	author	NN
cord-015910-d9gxew91	519	12	's	's	POS
cord-015910-d9gxew91	519	13	laboratory	laboratory	NN
cord-015910-d9gxew91	519	14	conducted	conduct	VBD
cord-015910-d9gxew91	519	15	a	a	DT
cord-015910-d9gxew91	519	16	study	study	NN
cord-015910-d9gxew91	519	17	on	on	IN
cord-015910-d9gxew91	519	18	111	111	CD
cord-015910-d9gxew91	519	19	young	young	JJ
cord-015910-d9gxew91	519	20	men	man	NNS
cord-015910-d9gxew91	519	21	fed	feed	VBD
cord-015910-d9gxew91	519	22	6	6	CD
cord-015910-d9gxew91	519	23	g	g	NN
cord-015910-d9gxew91	519	24	fish	fish	NN
cord-015910-d9gxew91	519	25	oil	oil	NN
cord-015910-d9gxew91	519	26	daily	daily	NN
cord-015910-d9gxew91	519	27	for	for	IN
cord-015910-d9gxew91	519	28	12	12	CD
cord-015910-d9gxew91	519	29	wk	wk	NNS
cord-015910-d9gxew91	519	30	and	and	CC
cord-015910-d9gxew91	519	31	measured	measure	VBD
cord-015910-d9gxew91	519	32	TNF	TNF	NNP
cord-015910-d9gxew91	519	33	-	-	HYPH
cord-015910-d9gxew91	519	34	tx	tx	NNP
cord-015910-d9gxew91	519	35	production	production	NN
cord-015910-d9gxew91	519	36	by	by	IN
cord-015910-d9gxew91	519	37	PBMCs	pbmc	NNS
cord-015910-d9gxew91	519	38	before	before	IN
cord-015910-d9gxew91	519	39	and	and	CC
cord-015910-d9gxew91	519	40	after	after	IN
cord-015910-d9gxew91	519	41	supplementation	supplementation	NN
cord-015910-d9gxew91	519	42	in	in	IN
cord-015910-d9gxew91	519	43	relation	relation	NN
cord-015910-d9gxew91	519	44	to	to	IN
cord-015910-d9gxew91	519	45	the	the	DT
cord-015910-d9gxew91	519	46	SNP	SNP	NNP
cord-015910-d9gxew91	519	47	at	at	IN
cord-015910-d9gxew91	519	48	-308	-308	NN
cord-015910-d9gxew91	519	49	in	in	IN
cord-015910-d9gxew91	519	50	the	the	DT
cord-015910-d9gxew91	519	51	TNF	TNF	NNP
cord-015910-d9gxew91	519	52	-	-	HYPH
cord-015910-d9gxew91	519	53	o~	o~	NNP
cord-015910-d9gxew91	519	54	and	and	CC
cord-015910-d9gxew91	519	55	at	at	IN
cord-015910-d9gxew91	519	56	+252	+252	NNP
cord-015910-d9gxew91	519	57	in	in	IN
cord-015910-d9gxew91	519	58	the	the	DT
cord-015910-d9gxew91	519	59	LT	LT	NNP
cord-015910-d9gxew91	519	60	-	-	HYPH
cord-015910-d9gxew91	519	61	tx	tx	NNP
cord-015910-d9gxew91	519	62	genes	gene	NNS
cord-015910-d9gxew91	519	63	.	.	.
cord-015910-d9gxew91	520	1	No	no	DT
cord-015910-d9gxew91	520	2	significant	significant	JJ
cord-015910-d9gxew91	520	3	effect	effect	NN
cord-015910-d9gxew91	520	4	of	of	IN
cord-015910-d9gxew91	520	5	fish	fish	NN
cord-015910-d9gxew91	520	6	oil	oil	NN
cord-015910-d9gxew91	520	7	on	on	IN
cord-015910-d9gxew91	520	8	cytokine	cytokine	NN
cord-015910-d9gxew91	520	9	production	production	NN
cord-015910-d9gxew91	520	10	was	be	VBD
cord-015910-d9gxew91	520	11	noted	note	VBN
cord-015910-d9gxew91	520	12	in	in	IN
cord-015910-d9gxew91	520	13	the	the	DT
cord-015910-d9gxew91	520	14	group	group	NN
cord-015910-d9gxew91	520	15	as	as	IN
cord-015910-d9gxew91	520	16	a	a	DT
cord-015910-d9gxew91	520	17	whole	whole	NN
cord-015910-d9gxew91	520	18	.	.	.
cord-015910-d9gxew91	521	1	However	however	RB
cord-015910-d9gxew91	521	2	,	,	,
cord-015910-d9gxew91	521	3	when	when	WRB
cord-015910-d9gxew91	521	4	data	datum	NNS
cord-015910-d9gxew91	521	5	were	be	VBD
cord-015910-d9gxew91	521	6	examined	examine	VBN
cord-015910-d9gxew91	521	7	according	accord	VBG
cord-015910-d9gxew91	521	8	to	to	IN
cord-015910-d9gxew91	521	9	tertile	tertile	NNP
cord-015910-d9gxew91	521	10	of	of	IN
cord-015910-d9gxew91	521	11	TNF	TNF	NNP
cord-015910-d9gxew91	521	12	-	-	HYPH
cord-015910-d9gxew91	521	13	ct	ct	NNP
cord-015910-d9gxew91	521	14	production	production	NN
cord-015910-d9gxew91	521	15	prior	prior	RB
cord-015910-d9gxew91	521	16	to	to	IN
cord-015910-d9gxew91	521	17	supplementation	supplementation	NN
cord-015910-d9gxew91	521	18	,	,	,
cord-015910-d9gxew91	521	19	homozygosity	homozygosity	NN
cord-015910-d9gxew91	521	20	for	for	IN
cord-015910-d9gxew91	521	21	TNFB2	TNFB2	NNP
cord-015910-d9gxew91	522	1	(	(	-LRB-
cord-015910-d9gxew91	522	2	LT	LT	NNP
cord-015910-d9gxew91	522	3	-	-	HYPH
cord-015910-d9gxew91	522	4	o~+	o~+	$
cord-015910-d9gxew91	522	5	252	252	CD
cord-015910-d9gxew91	522	6	A	A	NNP
cord-015910-d9gxew91	522	7	)	)	-RRB-
cord-015910-d9gxew91	522	8	was	be	VBD
cord-015910-d9gxew91	522	9	2.5	2.5	CD
cord-015910-d9gxew91	522	10	times	time	NNS
cord-015910-d9gxew91	522	11	more	more	RBR
cord-015910-d9gxew91	522	12	frequent	frequent	JJ
cord-015910-d9gxew91	522	13	in	in	IN
cord-015910-d9gxew91	522	14	the	the	DT
cord-015910-d9gxew91	522	15	highest	high	JJS
cord-015910-d9gxew91	522	16	than	than	IN
cord-015910-d9gxew91	522	17	in	in	IN
cord-015910-d9gxew91	522	18	the	the	DT
cord-015910-d9gxew91	522	19	lowest	low	JJS
cord-015910-d9gxew91	522	20	tertile	tertile	NN
cord-015910-d9gxew91	522	21	of	of	IN
cord-015910-d9gxew91	522	22	production	production	NN
cord-015910-d9gxew91	522	23	.	.	.
cord-015910-d9gxew91	523	1	The	the	DT
cord-015910-d9gxew91	523	2	percentage	percentage	NN
cord-015910-d9gxew91	523	3	of	of	IN
cord-015910-d9gxew91	523	4	individuals	individual	NNS
cord-015910-d9gxew91	523	5	in	in	IN
cord-015910-d9gxew91	523	6	whom	whom	WP
cord-015910-d9gxew91	523	7	fish	fish	VBP
cord-015910-d9gxew91	523	8	oil	oil	NN
cord-015910-d9gxew91	523	9	suppressed	suppress	VBN
cord-015910-d9gxew91	523	10	production	production	NN
cord-015910-d9gxew91	523	11	was	be	VBD
cord-015910-d9gxew91	523	12	lowest	low	JJS
cord-015910-d9gxew91	523	13	(	(	-LRB-
cord-015910-d9gxew91	523	14	22	22	CD
cord-015910-d9gxew91	523	15	%	%	NN
cord-015910-d9gxew91	523	16	)	)	-RRB-
cord-015910-d9gxew91	523	17	in	in	IN
cord-015910-d9gxew91	523	18	the	the	DT
cord-015910-d9gxew91	523	19	lowest	low	JJS
cord-015910-d9gxew91	523	20	tertile	tertile	JJ
cord-015910-d9gxew91	523	21	and	and	CC
cord-015910-d9gxew91	523	22	doubled	double	VBD
cord-015910-d9gxew91	523	23	with	with	IN
cord-015910-d9gxew91	523	24	each	each	DT
cord-015910-d9gxew91	523	25	ascending	ascend	VBG
cord-015910-d9gxew91	523	26	tertile	tertile	NN
cord-015910-d9gxew91	523	27	.	.	.
cord-015910-d9gxew91	524	1	In	in	IN
cord-015910-d9gxew91	524	2	the	the	DT
cord-015910-d9gxew91	524	3	highest	high	JJS
cord-015910-d9gxew91	524	4	tertile	tertile	JJ
cord-015910-d9gxew91	524	5	,	,	,
cord-015910-d9gxew91	524	6	mean	mean	JJ
cord-015910-d9gxew91	524	7	values	value	NNS
cord-015910-d9gxew91	524	8	were	be	VBD
cord-015910-d9gxew91	524	9	decreased	decrease	VBN
cord-015910-d9gxew91	524	10	by	by	IN
cord-015910-d9gxew91	524	11	43	43	CD
cord-015910-d9gxew91	524	12	%	%	NN
cord-015910-d9gxew91	524	13	(	(	-LRB-
cord-015910-d9gxew91	524	14	p	p	NN
cord-015910-d9gxew91	524	15	<	<	XX
cord-015910-d9gxew91	524	16	0.05	0.05	CD
cord-015910-d9gxew91	524	17	)	)	-RRB-
cord-015910-d9gxew91	524	18	.	.	.
cord-015910-d9gxew91	525	1	In	in	IN
cord-015910-d9gxew91	525	2	the	the	DT
cord-015910-d9gxew91	525	3	lowest	low	JJS
cord-015910-d9gxew91	525	4	tertile	tertile	JJ
cord-015910-d9gxew91	525	5	,	,	,
cord-015910-d9gxew91	525	6	mean	mean	JJ
cord-015910-d9gxew91	525	7	values	value	NNS
cord-015910-d9gxew91	525	8	were	be	VBD
cord-015910-d9gxew91	525	9	increased	increase	VBN
cord-015910-d9gxew91	525	10	by	by	IN
cord-015910-d9gxew91	525	11	62	62	CD
cord-015910-d9gxew91	525	12	%	%	NN
cord-015910-d9gxew91	525	13	(	(	-LRB-
cord-015910-d9gxew91	525	14	p	p	NN
cord-015910-d9gxew91	525	15	<	<	XX
cord-015910-d9gxew91	525	16	0.05	0.05	CD
cord-015910-d9gxew91	525	17	)	)	-RRB-
cord-015910-d9gxew91	525	18	.	.	.
cord-015910-d9gxew91	526	1	TNFB2	TNFB2	NNP
cord-015910-d9gxew91	527	1	(	(	-LRB-
cord-015910-d9gxew91	527	2	LT	LT	NNP
cord-015910-d9gxew91	527	3	-	-	HYPH
cord-015910-d9gxew91	527	4	cz+252	cz+252	NNP
cord-015910-d9gxew91	527	5	AA	AA	NNP
cord-015910-d9gxew91	527	6	)	)	-RRB-
cord-015910-d9gxew91	527	7	homozygotes	homozygote	NNS
cord-015910-d9gxew91	527	8	were	be	VBD
cord-015910-d9gxew91	527	9	strongly	strongly	RB
cord-015910-d9gxew91	527	10	represented	represent	VBN
cord-015910-d9gxew91	527	11	among	among	IN
cord-015910-d9gxew91	527	12	unresponsive	unresponsive	JJ
cord-015910-d9gxew91	527	13	individuals	individual	NNS
cord-015910-d9gxew91	527	14	in	in	IN
cord-015910-d9gxew91	527	15	the	the	DT
cord-015910-d9gxew91	527	16	lowest	low	JJS
cord-015910-d9gxew91	527	17	tertile	tertile	NN
cord-015910-d9gxew91	527	18	of	of	IN
cord-015910-d9gxew91	527	19	TNF	TNF	NNP
cord-015910-d9gxew91	527	20	-	-	HYPH
cord-015910-d9gxew91	527	21	cz	cz	NNP
cord-015910-d9gxew91	527	22	production	production	NN
cord-015910-d9gxew91	527	23	prior	prior	RB
cord-015910-d9gxew91	527	24	to	to	IN
cord-015910-d9gxew91	527	25	supplementation	supplementation	NN
cord-015910-d9gxew91	527	26	.	.	.
cord-015910-d9gxew91	528	1	In	in	IN
cord-015910-d9gxew91	528	2	this	this	DT
cord-015910-d9gxew91	528	3	lowest	low	JJS
cord-015910-d9gxew91	528	4	tertile	tertile	NN
cord-015910-d9gxew91	528	5	,	,	,
cord-015910-d9gxew91	528	6	only	only	RB
cord-015910-d9gxew91	528	7	TNFB	TNFB	NNP
cord-015910-d9gxew91	528	8	l	l	NN
cord-015910-d9gxew91	528	9	/	/	,
cord-015910-d9gxew91	528	10	B2	b2	NN
cord-015910-d9gxew91	528	11	(	(	-LRB-
cord-015910-d9gxew91	528	12	LT	LT	NNP
cord-015910-d9gxew91	528	13	-	-	HYPH
cord-015910-d9gxew91	528	14	o~+252	o~+252	NNP
cord-015910-d9gxew91	528	15	GA	GA	NNP
cord-015910-d9gxew91	528	16	)	)	-RRB-
cord-015910-d9gxew91	528	17	heterozygous	heterozygous	JJ
cord-015910-d9gxew91	528	18	subjects	subject	NNS
cord-015910-d9gxew91	528	19	were	be	VBD
cord-015910-d9gxew91	528	20	responsive	responsive	JJ
cord-015910-d9gxew91	528	21	to	to	IN
cord-015910-d9gxew91	528	22	the	the	DT
cord-015910-d9gxew91	528	23	suppressive	suppressive	JJ
cord-015910-d9gxew91	528	24	effects	effect	NNS
cord-015910-d9gxew91	528	25	of	of	IN
cord-015910-d9gxew91	528	26	fish	fish	NN
cord-015910-d9gxew91	528	27	oil	oil	NN
cord-015910-d9gxew91	528	28	.	.	.
cord-015910-d9gxew91	529	1	In	in	IN
cord-015910-d9gxew91	529	2	the	the	DT
cord-015910-d9gxew91	529	3	medium	medium	NN
cord-015910-d9gxew91	529	4	tertile	tertile	NN
cord-015910-d9gxew91	529	5	,	,	,
cord-015910-d9gxew91	529	6	this	this	DT
cord-015910-d9gxew91	529	7	genotype	genotype	NN
cord-015910-d9gxew91	529	8	was	be	VBD
cord-015910-d9gxew91	529	9	six	six	CD
cord-015910-d9gxew91	529	10	times	time	NNS
cord-015910-d9gxew91	529	11	more	more	RBR
cord-015910-d9gxew91	529	12	frequent	frequent	JJ
cord-015910-d9gxew91	529	13	than	than	IN
cord-015910-d9gxew91	529	14	other	other	JJ
cord-015910-d9gxew91	529	15	LT	LT	NNP
cord-015910-d9gxew91	529	16	-	-	HYPH
cord-015910-d9gxew91	529	17	t~	t~	NNP
cord-015910-d9gxew91	529	18	genotypes	genotype	NNS
cord-015910-d9gxew91	529	19	among	among	IN
cord-015910-d9gxew91	529	20	responsive	responsive	JJ
cord-015910-d9gxew91	529	21	individuals	individual	NNS
cord-015910-d9gxew91	529	22	.	.	.
cord-015910-d9gxew91	530	1	No	no	DT
cord-015910-d9gxew91	530	2	relationship	relationship	NN
cord-015910-d9gxew91	530	3	between	between	IN
cord-015910-d9gxew91	530	4	possession	possession	NN
cord-015910-d9gxew91	530	5	of	of	IN
cord-015910-d9gxew91	530	6	TNF	TNF	NNP
cord-015910-d9gxew91	530	7	1	1	CD
cord-015910-d9gxew91	530	8	or	or	CC
cord-015910-d9gxew91	530	9	2	2	CD
cord-015910-d9gxew91	531	1	(	(	-LRB-
cord-015910-d9gxew91	531	2	TNF	TNF	NNP
cord-015910-d9gxew91	531	3	-	-	HYPH
cord-015910-d9gxew91	531	4	ot-308	ot-308	NNP
cord-015910-d9gxew91	531	5	G	G	NNP
cord-015910-d9gxew91	531	6	or	or	CC
cord-015910-d9gxew91	531	7	A	a	NN
cord-015910-d9gxew91	531	8	)	)	-RRB-
cord-015910-d9gxew91	531	9	alleles	allele	NNS
cord-015910-d9gxew91	531	10	and	and	CC
cord-015910-d9gxew91	531	11	responsiveness	responsiveness	NN
cord-015910-d9gxew91	531	12	to	to	TO
cord-015910-d9gxew91	531	13	fish	fish	VB
cord-015910-d9gxew91	531	14	oil	oil	NN
cord-015910-d9gxew91	531	15	was	be	VBD
cord-015910-d9gxew91	531	16	found	find	VBN
cord-015910-d9gxew91	531	17	.	.	.
cord-015910-d9gxew91	532	1	Clearly	clearly	RB
cord-015910-d9gxew91	532	2	,	,	,
cord-015910-d9gxew91	532	3	although	although	IN
cord-015910-d9gxew91	532	4	the	the	DT
cord-015910-d9gxew91	532	5	level	level	NN
cord-015910-d9gxew91	532	6	of	of	IN
cord-015910-d9gxew91	532	7	inflammation	inflammation	NN
cord-015910-d9gxew91	532	8	determines	determine	VBZ
cord-015910-d9gxew91	532	9	whether	whether	IN
cord-015910-d9gxew91	532	10	fish	fish	NN
cord-015910-d9gxew91	532	11	oil	oil	NN
cord-015910-d9gxew91	532	12	will	will	MD
cord-015910-d9gxew91	532	13	exert	exert	VB
cord-015910-d9gxew91	532	14	an	an	DT
cord-015910-d9gxew91	532	15	anti	anti	JJ
cord-015910-d9gxew91	532	16	-	-	JJ
cord-015910-d9gxew91	532	17	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	532	18	influence	influence	NN
cord-015910-d9gxew91	532	19	or	or	CC
cord-015910-d9gxew91	532	20	not	not	RB
cord-015910-d9gxew91	532	21	and	and	CC
cord-015910-d9gxew91	532	22	is	be	VBZ
cord-015910-d9gxew91	532	23	influenced	influence	VBN
cord-015910-d9gxew91	532	24	by	by	IN
cord-015910-d9gxew91	532	25	the	the	DT
cord-015910-d9gxew91	532	26	TNFB2	tnfb2	NN
cord-015910-d9gxew91	533	1	(	(	-LRB-
cord-015910-d9gxew91	533	2	LT	LT	NNP
cord-015910-d9gxew91	533	3	-	-	HYPH
cord-015910-d9gxew91	533	4	ct+252	ct+252	NNP
cord-015910-d9gxew91	533	5	A	a	CD
cord-015910-d9gxew91	533	6	)	)	-RRB-
cord-015910-d9gxew91	533	7	allele	allele	NN
cord-015910-d9gxew91	533	8	,	,	,
cord-015910-d9gxew91	533	9	the	the	DT
cord-015910-d9gxew91	533	10	precise	precise	JJ
cord-015910-d9gxew91	533	11	genomic	genomic	JJ
cord-015910-d9gxew91	533	12	mechanism	mechanism	NN
cord-015910-d9gxew91	533	13	for	for	IN
cord-015910-d9gxew91	533	14	an	an	DT
cord-015910-d9gxew91	533	15	anti	anti	JJ
cord-015910-d9gxew91	533	16	-	-	JJ
cord-015910-d9gxew91	533	17	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	533	18	effect	effect	NN
cord-015910-d9gxew91	533	19	is	be	VBZ
cord-015910-d9gxew91	533	20	unclear	unclear	JJ
cord-015910-d9gxew91	533	21	at	at	IN
cord-015910-d9gxew91	533	22	present	present	JJ
cord-015910-d9gxew91	533	23	.	.	.
cord-015910-d9gxew91	534	1	Antioxidant	antioxidant	NN
cord-015910-d9gxew91	534	2	intake	intake	NN
cord-015910-d9gxew91	534	3	also	also	RB
cord-015910-d9gxew91	534	4	modifies	modify	VBZ
cord-015910-d9gxew91	534	5	cytokine	cytokine	JJ
cord-015910-d9gxew91	534	6	production	production	NN
cord-015910-d9gxew91	534	7	.	.	.
cord-015910-d9gxew91	535	1	In	in	IN
cord-015910-d9gxew91	535	2	a	a	DT
cord-015910-d9gxew91	535	3	study	study	NN
cord-015910-d9gxew91	535	4	on	on	IN
cord-015910-d9gxew91	535	5	healthy	healthy	JJ
cord-015910-d9gxew91	535	6	men	man	NNS
cord-015910-d9gxew91	535	7	and	and	CC
cord-015910-d9gxew91	535	8	women	woman	NNS
cord-015910-d9gxew91	535	9	and	and	CC
cord-015910-d9gxew91	535	10	smokers	smoker	NNS
cord-015910-d9gxew91	535	11	,	,	,
cord-015910-d9gxew91	535	12	dietary	dietary	JJ
cord-015910-d9gxew91	535	13	supplementation	supplementation	NN
cord-015910-d9gxew91	535	14	with	with	IN
cord-015910-d9gxew91	535	15	600	600	CD
cord-015910-d9gxew91	535	16	IU	IU	NNP
cord-015910-d9gxew91	535	17	/	/	SYM
cord-015910-d9gxew91	535	18	d	d	NNP
cord-015910-d9gxew91	535	19	ct	ct	NNP
cord-015910-d9gxew91	535	20	-	-	HYPH
cord-015910-d9gxew91	535	21	tocopherol	tocopherol	NN
cord-015910-d9gxew91	535	22	for	for	IN
cord-015910-d9gxew91	535	23	1	1	CD
cord-015910-d9gxew91	535	24	mo	mo	NN
cord-015910-d9gxew91	535	25	suppressed	suppress	VBD
cord-015910-d9gxew91	535	26	the	the	DT
cord-015910-d9gxew91	535	27	ability	ability	NN
cord-015910-d9gxew91	535	28	of	of	IN
cord-015910-d9gxew91	535	29	PBMCs	pbmc	NNS
cord-015910-d9gxew91	535	30	to	to	TO
cord-015910-d9gxew91	535	31	produce	produce	VB
cord-015910-d9gxew91	535	32	TNF	TNF	NNP
cord-015910-d9gxew91	535	33	-	-	HYPH
cord-015910-d9gxew91	535	34	t~.	t~.	NNP
cord-015910-d9gxew91	535	35	Production	production	NN
cord-015910-d9gxew91	535	36	was	be	VBD
cord-015910-d9gxew91	535	37	reduced	reduce	VBN
cord-015910-d9gxew91	535	38	by	by	IN
cord-015910-d9gxew91	535	39	22	22	CD
cord-015910-d9gxew91	535	40	and	and	CC
cord-015910-d9gxew91	535	41	33	33	CD
cord-015910-d9gxew91	535	42	%	%	NN
cord-015910-d9gxew91	535	43	in	in	IN
cord-015910-d9gxew91	535	44	nonsmokers	nonsmoker	NNS
cord-015910-d9gxew91	535	45	and	and	CC
cord-015910-d9gxew91	535	46	smokers	smoker	NNS
cord-015910-d9gxew91	535	47	,	,	,
cord-015910-d9gxew91	535	48	respectively	respectively	RB
cord-015910-d9gxew91	535	49	(	(	-LRB-
cord-015910-d9gxew91	535	50	Mol	Mol	NNP
cord-015910-d9gxew91	535	51	et	et	FW
cord-015910-d9gxew91	535	52	al	al	NNP
cord-015910-d9gxew91	535	53	.	.	NNP
cord-015910-d9gxew91	535	54	,	,	,
cord-015910-d9gxew91	535	55	1997	1997	CD
cord-015910-d9gxew91	535	56	)	)	-RRB-
cord-015910-d9gxew91	535	57	.	.	.
cord-015910-d9gxew91	536	1	In	in	IN
cord-015910-d9gxew91	536	2	a	a	DT
cord-015910-d9gxew91	536	3	similar	similar	JJ
cord-015910-d9gxew91	536	4	dietary	dietary	JJ
cord-015910-d9gxew91	536	5	intervention	intervention	NN
cord-015910-d9gxew91	536	6	study	study	NN
cord-015910-d9gxew91	536	7	on	on	IN
cord-015910-d9gxew91	536	8	normolipaemic	normolipaemic	NNP
cord-015910-d9gxew91	536	9	and	and	CC
cord-015910-d9gxew91	536	10	hypertriglyceridaemic	hypertriglyceridaemic	NNP
cord-015910-d9gxew91	536	11	subjects	subject	NNS
cord-015910-d9gxew91	536	12	given	give	VBN
cord-015910-d9gxew91	536	13	600	600	CD
cord-015910-d9gxew91	536	14	IU/	iu/	NN
cord-015910-d9gxew91	536	15	d	d	NN
cord-015910-d9gxew91	536	16	of	of	IN
cord-015910-d9gxew91	536	17	o~-tocopherol	o~-tocopherol	DT
cord-015910-d9gxew91	536	18	for	for	IN
cord-015910-d9gxew91	536	19	6	6	CD
cord-015910-d9gxew91	536	20	wk	wk	NNS
cord-015910-d9gxew91	536	21	,	,	,
cord-015910-d9gxew91	536	22	reduced	reduce	VBN
cord-015910-d9gxew91	536	23	TNF	TNF	NNP
cord-015910-d9gxew91	536	24	-	-	HYPH
cord-015910-d9gxew91	536	25	o~	o~	NNP
cord-015910-d9gxew91	536	26	,	,	,
cord-015910-d9gxew91	536	27	IL-113	il-113	NN
cord-015910-d9gxew91	536	28	,	,	,
cord-015910-d9gxew91	536	29	and	and	CC
cord-015910-d9gxew91	537	1	IL-8	IL-8	NNP
cord-015910-d9gxew91	537	2	production	production	NN
cord-015910-d9gxew91	537	3	by	by	IN
cord-015910-d9gxew91	537	4	LPS	LPS	NNP
cord-015910-d9gxew91	537	5	-	-	HYPH
cord-015910-d9gxew91	537	6	stimulated	stimulate	VBN
cord-015910-d9gxew91	537	7	blood	blood	NN
cord-015910-d9gxew91	537	8	mononuclear	mononuclear	NN
cord-015910-d9gxew91	537	9	cells	cell	NNS
cord-015910-d9gxew91	537	10	occurred	occur	VBD
cord-015910-d9gxew91	537	11	(	(	-LRB-
cord-015910-d9gxew91	538	1	Mol	Mol	NNP
cord-015910-d9gxew91	538	2	et	et	NNP
cord-015910-d9gxew91	538	3	al	al	NNP
cord-015910-d9gxew91	538	4	.	.	.
cord-015910-d9gxew91	539	1	,	,	,
cord-015910-d9gxew91	539	2	1997	1997	CD
cord-015910-d9gxew91	539	3	;	;	:
cord-015910-d9gxew91	539	4	van	van	NNP
cord-015910-d9gxew91	539	5	Tits	Tits	NNP
cord-015910-d9gxew91	539	6	,	,	,
cord-015910-d9gxew91	539	7	Demacker	Demacker	NNP
cord-015910-d9gxew91	539	8	,	,	,
cord-015910-d9gxew91	539	9	de	de	NNP
cord-015910-d9gxew91	539	10	Graaf	Graaf	NNP
cord-015910-d9gxew91	539	11	,	,	,
cord-015910-d9gxew91	539	12	Hak	Hak	NNP
cord-015910-d9gxew91	539	13	-	-	HYPH
cord-015910-d9gxew91	539	14	Lemmers	Lemmers	NNP
cord-015910-d9gxew91	539	15	,	,	,
cord-015910-d9gxew91	539	16	&	&	CC
cord-015910-d9gxew91	539	17	Stalenhoef	Stalenhoef	NNP
cord-015910-d9gxew91	539	18	,	,	,
cord-015910-d9gxew91	539	19	2000	2000	CD
cord-015910-d9gxew91	539	20	)	)	-RRB-
cord-015910-d9gxew91	539	21	.	.	.
cord-015910-d9gxew91	540	1	A	a	DT
cord-015910-d9gxew91	540	2	similar	similar	JJ
cord-015910-d9gxew91	540	3	effect	effect	NN
cord-015910-d9gxew91	540	4	of	of	IN
cord-015910-d9gxew91	540	5	cx	cx	NN
cord-015910-d9gxew91	540	6	-	-	HYPH
cord-015910-d9gxew91	540	7	tocopherol	tocopherol	NN
cord-015910-d9gxew91	540	8	was	be	VBD
cord-015910-d9gxew91	540	9	noted	note	VBN
cord-015910-d9gxew91	540	10	in	in	IN
cord-015910-d9gxew91	540	11	a	a	DT
cord-015910-d9gxew91	540	12	study	study	NN
cord-015910-d9gxew91	540	13	on	on	IN
cord-015910-d9gxew91	540	14	normal	normal	JJ
cord-015910-d9gxew91	540	15	subjects	subject	NNS
cord-015910-d9gxew91	540	16	and	and	CC
cord-015910-d9gxew91	540	17	type	type	NN
cord-015910-d9gxew91	540	18	2	2	CD
cord-015910-d9gxew91	540	19	diabetics	diabetic	NNS
cord-015910-d9gxew91	540	20	(	(	-LRB-
cord-015910-d9gxew91	540	21	Devaraj	Devaraj	NNP
cord-015910-d9gxew91	540	22	&	&	CC
cord-015910-d9gxew91	540	23	Jialal	Jialal	NNP
cord-015910-d9gxew91	540	24	,	,	,
cord-015910-d9gxew91	540	25	2000	2000	CD
cord-015910-d9gxew91	540	26	)	)	-RRB-
cord-015910-d9gxew91	540	27	.	.	.
cord-015910-d9gxew91	541	1	However	however	RB
cord-015910-d9gxew91	541	2	,	,	,
cord-015910-d9gxew91	541	3	there	there	EX
cord-015910-d9gxew91	541	4	were	be	VBD
cord-015910-d9gxew91	541	5	large	large	JJ
cord-015910-d9gxew91	541	6	standard	standard	JJ
cord-015910-d9gxew91	541	7	deviations	deviation	NNS
cord-015910-d9gxew91	541	8	in	in	IN
cord-015910-d9gxew91	541	9	the	the	DT
cord-015910-d9gxew91	541	10	data	datum	NNS
cord-015910-d9gxew91	541	11	from	from	IN
cord-015910-d9gxew91	541	12	these	these	DT
cord-015910-d9gxew91	541	13	studies	study	NNS
cord-015910-d9gxew91	541	14	,	,	,
cord-015910-d9gxew91	541	15	indicating	indicate	VBG
cord-015910-d9gxew91	541	16	major	major	JJ
cord-015910-d9gxew91	541	17	intraindividual	intraindividual	JJ
cord-015910-d9gxew91	541	18	variability	variability	NN
cord-015910-d9gxew91	541	19	in	in	IN
cord-015910-d9gxew91	541	20	the	the	DT
cord-015910-d9gxew91	541	21	ability	ability	NN
cord-015910-d9gxew91	541	22	of	of	IN
cord-015910-d9gxew91	541	23	vitamin	vitamin	NN
cord-015910-d9gxew91	541	24	E	e	NN
cord-015910-d9gxew91	541	25	to	to	TO
cord-015910-d9gxew91	541	26	suppress	suppress	VB
cord-015910-d9gxew91	541	27	production	production	NN
cord-015910-d9gxew91	541	28	of	of	IN
cord-015910-d9gxew91	541	29	the	the	DT
cord-015910-d9gxew91	541	30	cytokine	cytokine	NN
cord-015910-d9gxew91	541	31	.	.	.
cord-015910-d9gxew91	542	1	Although	although	IN
cord-015910-d9gxew91	542	2	a	a	DT
cord-015910-d9gxew91	542	3	number	number	NN
cord-015910-d9gxew91	542	4	of	of	IN
cord-015910-d9gxew91	542	5	studies	study	NNS
cord-015910-d9gxew91	542	6	have	have	VBP
cord-015910-d9gxew91	542	7	shown	show	VBN
cord-015910-d9gxew91	542	8	that	that	IN
cord-015910-d9gxew91	542	9	o~-tocopherol	o~-tocopherol	PRP
cord-015910-d9gxew91	542	10	suppresses	suppress	VBZ
cord-015910-d9gxew91	542	11	superoxide	superoxide	NN
cord-015910-d9gxew91	542	12	production	production	NN
cord-015910-d9gxew91	542	13	,	,	,
cord-015910-d9gxew91	542	14	the	the	DT
cord-015910-d9gxew91	542	15	situation	situation	NN
cord-015910-d9gxew91	542	16	with	with	IN
cord-015910-d9gxew91	542	17	regard	regard	NN
cord-015910-d9gxew91	542	18	to	to	IN
cord-015910-d9gxew91	542	19	nitric	nitric	NN
cord-015910-d9gxew91	542	20	oxide	oxide	NN
cord-015910-d9gxew91	542	21	is	be	VBZ
cord-015910-d9gxew91	542	22	less	less	RBR
cord-015910-d9gxew91	542	23	clear	clear	JJ
cord-015910-d9gxew91	542	24	(	(	-LRB-
cord-015910-d9gxew91	543	1	Mol	Mol	NNP
cord-015910-d9gxew91	543	2	et	et	NNP
cord-015910-d9gxew91	543	3	al	al	NNP
cord-015910-d9gxew91	543	4	.	.	NNP
cord-015910-d9gxew91	543	5	,	,	,
cord-015910-d9gxew91	543	6	1997	1997	CD
cord-015910-d9gxew91	543	7	;	;	:
cord-015910-d9gxew91	543	8	van	van	NNP
cord-015910-d9gxew91	543	9	Tits	Tits	NNP
cord-015910-d9gxew91	543	10	et	et	FW
cord-015910-d9gxew91	543	11	al	al	NNP
cord-015910-d9gxew91	543	12	.	.	.
cord-015910-d9gxew91	544	1	,	,	,
cord-015910-d9gxew91	544	2	2000	2000	CD
cord-015910-d9gxew91	544	3	)	)	-RRB-
cord-015910-d9gxew91	544	4	n	n	NN
cord-015910-d9gxew91	545	1	The	the	DT
cord-015910-d9gxew91	545	2	a	a	DT
cord-015910-d9gxew91	545	3	-	-	HYPH
cord-015910-d9gxew91	545	4	tocopherol	tocopherol	NN
cord-015910-d9gxew91	545	5	derivative	derivative	JJ
cord-015910-d9gxew91	545	6	pentamethyl	pentamethyl	NNP
cord-015910-d9gxew91	545	7	-	-	HYPH
cord-015910-d9gxew91	545	8	hydroxychromane	hydroxychromane	NNP
cord-015910-d9gxew91	545	9	inhibited	inhibited	JJ
cord-015910-d9gxew91	545	10	LPS	LPS	NNP
cord-015910-d9gxew91	545	11	-	-	HYPH
cord-015910-d9gxew91	545	12	stimulated	stimulate	VBN
cord-015910-d9gxew91	545	13	NF	NF	NNP
cord-015910-d9gxew91	545	14	-	-	HYPH
cord-015910-d9gxew91	545	15	gB	gB	NNP
cord-015910-d9gxew91	545	16	and	and	CC
cord-015910-d9gxew91	545	17	iNOS	inos	JJ
cord-015910-d9gxew91	545	18	activation	activation	NN
cord-015910-d9gxew91	545	19	in	in	IN
cord-015910-d9gxew91	545	20	cultured	cultured	JJ
cord-015910-d9gxew91	545	21	J774	J774	NNS
cord-015910-d9gxew91	545	22	macrophages	macrophage	NNS
cord-015910-d9gxew91	545	23	(	(	-LRB-
cord-015910-d9gxew91	545	24	Hattori	Hattori	NNP
cord-015910-d9gxew91	545	25	,	,	,
cord-015910-d9gxew91	545	26	1995	1995	CD
cord-015910-d9gxew91	545	27	)	)	-RRB-
cord-015910-d9gxew91	545	28	.	.	.
cord-015910-d9gxew91	546	1	At	at	IN
cord-015910-d9gxew91	546	2	present	present	NN
cord-015910-d9gxew91	546	3	it	-PRON-	PRP
cord-015910-d9gxew91	546	4	is	be	VBZ
cord-015910-d9gxew91	546	5	not	not	RB
cord-015910-d9gxew91	546	6	known	know	VBN
cord-015910-d9gxew91	546	7	whether	whether	IN
cord-015910-d9gxew91	546	8	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	546	9	interact	interact	VBP
cord-015910-d9gxew91	546	10	differently	differently	RB
cord-015910-d9gxew91	546	11	with	with	IN
cord-015910-d9gxew91	546	12	SNPs	snp	NNS
cord-015910-d9gxew91	546	13	in	in	IN
cord-015910-d9gxew91	546	14	the	the	DT
cord-015910-d9gxew91	546	15	genes	gene	NNS
cord-015910-d9gxew91	546	16	associated	associate	VBN
cord-015910-d9gxew91	546	17	with	with	IN
cord-015910-d9gxew91	546	18	oxidant	oxidant	JJ
cord-015910-d9gxew91	546	19	stress	stress	NN
cord-015910-d9gxew91	546	20	and	and	CC
cord-015910-d9gxew91	546	21	inflammation	inflammation	NN
cord-015910-d9gxew91	546	22	than	than	IN
cord-015910-d9gxew91	546	23	they	-PRON-	PRP
cord-015910-d9gxew91	546	24	do	do	VBP
cord-015910-d9gxew91	546	25	with	with	IN
cord-015910-d9gxew91	546	26	the	the	DT
cord-015910-d9gxew91	546	27	other	other	JJ
cord-015910-d9gxew91	546	28	anti	anti	JJ
cord-015910-d9gxew91	546	29	-	-	JJ
cord-015910-d9gxew91	546	30	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	546	31	nutrient	nutrient	NN
cord-015910-d9gxew91	546	32	,	,	,
cord-015910-d9gxew91	546	33	n-3	n-3	NN
cord-015910-d9gxew91	546	34	PUFA	PUFA	NNS
cord-015910-d9gxew91	546	35	.	.	.
cord-015910-d9gxew91	547	1	This	this	DT
cord-015910-d9gxew91	547	2	topic	topic	NN
cord-015910-d9gxew91	547	3	is	be	VBZ
cord-015910-d9gxew91	547	4	currently	currently	RB
cord-015910-d9gxew91	547	5	an	an	DT
cord-015910-d9gxew91	547	6	area	area	NN
cord-015910-d9gxew91	547	7	of	of	IN
cord-015910-d9gxew91	547	8	active	active	JJ
cord-015910-d9gxew91	547	9	research	research	NN
cord-015910-d9gxew91	547	10	at	at	IN
cord-015910-d9gxew91	547	11	the	the	DT
cord-015910-d9gxew91	547	12	author	author	NN
cord-015910-d9gxew91	547	13	's	's	POS
cord-015910-d9gxew91	547	14	laboratory	laboratory	NN
cord-015910-d9gxew91	547	15	.	.	.
cord-015910-d9gxew91	548	1	Proteomic	Proteomic	NNP
cord-015910-d9gxew91	548	2	studies	study	NNS
cord-015910-d9gxew91	548	3	have	have	VBP
cord-015910-d9gxew91	548	4	shown	show	VBN
cord-015910-d9gxew91	548	5	that	that	IN
cord-015910-d9gxew91	548	6	iNOS	inos	NN
cord-015910-d9gxew91	548	7	and	and	CC
cord-015910-d9gxew91	548	8	SOD	sod	NN
cord-015910-d9gxew91	548	9	are	be	VBP
cord-015910-d9gxew91	548	10	both	both	DT
cord-015910-d9gxew91	548	11	influenced	influence	VBN
cord-015910-d9gxew91	548	12	by	by	IN
cord-015910-d9gxew91	548	13	the	the	DT
cord-015910-d9gxew91	548	14	NRAMP	NRAMP	NNP
cord-015910-d9gxew91	548	15	1	1	CD
cord-015910-d9gxew91	548	16	gene	gene	NN
cord-015910-d9gxew91	548	17	(	(	-LRB-
cord-015910-d9gxew91	548	18	Kovorova	Kovorova	NNP
cord-015910-d9gxew91	548	19	,	,	,
cord-015910-d9gxew91	548	20	Necasova	Necasova	NNP
cord-015910-d9gxew91	548	21	,	,	,
cord-015910-d9gxew91	548	22	Porkertova	Porkertova	NNP
cord-015910-d9gxew91	548	23	,	,	,
cord-015910-d9gxew91	548	24	Radzoich	Radzoich	NNP
cord-015910-d9gxew91	548	25	,	,	,
cord-015910-d9gxew91	548	26	&	&	CC
cord-015910-d9gxew91	548	27	Macela	Macela	NNP
cord-015910-d9gxew91	548	28	,	,	,
cord-015910-d9gxew91	548	29	2001	2001	CD
cord-015910-d9gxew91	548	30	)	)	-RRB-
cord-015910-d9gxew91	548	31	.	.	.
cord-015910-d9gxew91	549	1	The	the	DT
cord-015910-d9gxew91	549	2	production	production	NN
cord-015910-d9gxew91	549	3	of	of	IN
cord-015910-d9gxew91	549	4	oxidant	oxidant	JJ
cord-015910-d9gxew91	549	5	molecules	molecule	NNS
cord-015910-d9gxew91	549	6	enhancing	enhance	VBG
cord-015910-d9gxew91	549	7	pro	pro	JJ
cord-015910-d9gxew91	549	8	-	-	JJ
cord-015910-d9gxew91	549	9	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	549	10	cytokine	cytokine	NN
cord-015910-d9gxew91	549	11	production	production	NN
cord-015910-d9gxew91	549	12	via	via	IN
cord-015910-d9gxew91	549	13	high	high	JJ
cord-015910-d9gxew91	549	14	levels	level	NNS
cord-015910-d9gxew91	549	15	of	of	IN
cord-015910-d9gxew91	549	16	NF	NF	NNP
cord-015910-d9gxew91	549	17	-	-	HYPH
cord-015910-d9gxew91	549	18	kB	kb	CD
cord-015910-d9gxew91	549	19	activation	activation	NN
cord-015910-d9gxew91	549	20	may	may	MD
cord-015910-d9gxew91	549	21	thus	thus	RB
cord-015910-d9gxew91	549	22	be	be	VB
cord-015910-d9gxew91	549	23	under	under	IN
cord-015910-d9gxew91	549	24	a	a	DT
cord-015910-d9gxew91	549	25	genomic	genomic	JJ
cord-015910-d9gxew91	549	26	influence	influence	NN
cord-015910-d9gxew91	549	27	owing	owe	VBG
cord-015910-d9gxew91	549	28	to	to	IN
cord-015910-d9gxew91	549	29	the	the	DT
cord-015910-d9gxew91	549	30	aforementioned	aforementioned	JJ
cord-015910-d9gxew91	549	31	variations	variation	NNS
cord-015910-d9gxew91	549	32	in	in	IN
cord-015910-d9gxew91	549	33	the	the	DT
cord-015910-d9gxew91	549	34	NRAMP1	NRAMP1	NNP
cord-015910-d9gxew91	549	35	gene	gene	NN
cord-015910-d9gxew91	549	36	(	(	-LRB-
cord-015910-d9gxew91	549	37	Formica	Formica	NNP
cord-015910-d9gxew91	549	38	,	,	,
cord-015910-d9gxew91	549	39	Roach	Roach	NNP
cord-015910-d9gxew91	549	40	,	,	,
cord-015910-d9gxew91	549	41	&	&	CC
cord-015910-d9gxew91	549	42	Blackwell	Blackwell	NNP
cord-015910-d9gxew91	549	43	,	,	,
cord-015910-d9gxew91	549	44	1994	1994	CD
cord-015910-d9gxew91	549	45	)	)	-RRB-
cord-015910-d9gxew91	549	46	.	.	.
cord-015910-d9gxew91	550	1	A	a	DT
cord-015910-d9gxew91	550	2	better	well	JJR
cord-015910-d9gxew91	550	3	understanding	understanding	NN
cord-015910-d9gxew91	550	4	of	of	IN
cord-015910-d9gxew91	550	5	this	this	DT
cord-015910-d9gxew91	550	6	interaction	interaction	NN
cord-015910-d9gxew91	550	7	and	and	CC
cord-015910-d9gxew91	550	8	of	of	IN
cord-015910-d9gxew91	550	9	the	the	DT
cord-015910-d9gxew91	550	10	interaction	interaction	NN
cord-015910-d9gxew91	550	11	of	of	IN
cord-015910-d9gxew91	550	12	n-3	n-3	NN
cord-015910-d9gxew91	550	13	PUFAs	pufa	NNS
cord-015910-d9gxew91	550	14	and	and	CC
cord-015910-d9gxew91	550	15	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	550	16	with	with	IN
cord-015910-d9gxew91	550	17	genotype	genotype	NN
cord-015910-d9gxew91	550	18	may	may	MD
cord-015910-d9gxew91	550	19	allow	allow	VB
cord-015910-d9gxew91	550	20	the	the	DT
cord-015910-d9gxew91	550	21	better	well	JJR
cord-015910-d9gxew91	550	22	design	design	NN
cord-015910-d9gxew91	550	23	of	of	IN
cord-015910-d9gxew91	550	24	nutrient	nutrient	NN
cord-015910-d9gxew91	550	25	products	product	NNS
cord-015910-d9gxew91	550	26	for	for	IN
cord-015910-d9gxew91	550	27	the	the	DT
cord-015910-d9gxew91	550	28	treatment	treatment	NN
cord-015910-d9gxew91	550	29	of	of	IN
cord-015910-d9gxew91	550	30	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	550	31	disease	disease	NN
cord-015910-d9gxew91	550	32	.	.	.
cord-015910-d9gxew91	551	1	It	-PRON-	PRP
cord-015910-d9gxew91	551	2	is	be	VBZ
cord-015910-d9gxew91	551	3	clear	clear	JJ
cord-015910-d9gxew91	551	4	from	from	IN
cord-015910-d9gxew91	551	5	the	the	DT
cord-015910-d9gxew91	551	6	current	current	JJ
cord-015910-d9gxew91	551	7	understanding	understanding	NN
cord-015910-d9gxew91	551	8	about	about	IN
cord-015910-d9gxew91	551	9	the	the	DT
cord-015910-d9gxew91	551	10	purpose	purpose	NN
cord-015910-d9gxew91	551	11	and	and	CC
cord-015910-d9gxew91	551	12	functioning	functioning	NN
cord-015910-d9gxew91	551	13	of	of	IN
cord-015910-d9gxew91	551	14	the	the	DT
cord-015910-d9gxew91	551	15	immune	immune	JJ
cord-015910-d9gxew91	551	16	system	system	NN
cord-015910-d9gxew91	551	17	throughout	throughout	IN
cord-015910-d9gxew91	551	18	the	the	DT
cord-015910-d9gxew91	551	19	life	life	NN
cord-015910-d9gxew91	551	20	cycle	cycle	NN
cord-015910-d9gxew91	551	21	that	that	IN
cord-015910-d9gxew91	551	22	it	-PRON-	PRP
cord-015910-d9gxew91	551	23	is	be	VBZ
cord-015910-d9gxew91	551	24	a	a	DT
cord-015910-d9gxew91	551	25	powerful	powerful	JJ
cord-015910-d9gxew91	551	26	biological	biological	JJ
cord-015910-d9gxew91	551	27	entity	entity	NN
cord-015910-d9gxew91	551	28	that	that	WDT
cord-015910-d9gxew91	551	29	profoundly	profoundly	RB
cord-015910-d9gxew91	551	30	alters	alter	VBZ
cord-015910-d9gxew91	551	31	body	body	NN
cord-015910-d9gxew91	551	32	function	function	NN
cord-015910-d9gxew91	551	33	while	while	IN
cord-015910-d9gxew91	551	34	it	-PRON-	PRP
cord-015910-d9gxew91	551	35	is	be	VBZ
cord-015910-d9gxew91	551	36	carrying	carry	VBG
cord-015910-d9gxew91	551	37	out	out	RP
cord-015910-d9gxew91	551	38	its	-PRON-	PRP$
cord-015910-d9gxew91	551	39	prime	prime	JJ
cord-015910-d9gxew91	551	40	purpose	purpose	NN
cord-015910-d9gxew91	551	41	of	of	IN
cord-015910-d9gxew91	551	42	defending	defend	VBG
cord-015910-d9gxew91	551	43	the	the	DT
cord-015910-d9gxew91	551	44	body	body	NN
cord-015910-d9gxew91	551	45	against	against	IN
cord-015910-d9gxew91	551	46	invasion	invasion	NN
cord-015910-d9gxew91	551	47	by	by	IN
cord-015910-d9gxew91	551	48	pathogens	pathogen	NNS
cord-015910-d9gxew91	551	49	.	.	.
cord-015910-d9gxew91	552	1	However	however	RB
cord-015910-d9gxew91	552	2	,	,	,
cord-015910-d9gxew91	552	3	within	within	IN
cord-015910-d9gxew91	552	4	the	the	DT
cord-015910-d9gxew91	552	5	response	response	NN
cord-015910-d9gxew91	552	6	lie	lie	VBP
cord-015910-d9gxew91	552	7	the	the	DT
cord-015910-d9gxew91	552	8	seeds	seed	NNS
cord-015910-d9gxew91	552	9	of	of	IN
cord-015910-d9gxew91	552	10	disaster	disaster	NN
cord-015910-d9gxew91	552	11	at	at	IN
cord-015910-d9gxew91	552	12	an	an	DT
cord-015910-d9gxew91	552	13	individual	individual	JJ
cord-015910-d9gxew91	552	14	level	level	NN
cord-015910-d9gxew91	552	15	,	,	,
cord-015910-d9gxew91	552	16	for	for	IN
cord-015910-d9gxew91	552	17	the	the	DT
cord-015910-d9gxew91	552	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	552	19	component	component	NN
cord-015910-d9gxew91	552	20	of	of	IN
cord-015910-d9gxew91	552	21	the	the	DT
cord-015910-d9gxew91	552	22	response	response	NN
cord-015910-d9gxew91	552	23	can	can	MD
cord-015910-d9gxew91	552	24	turn	turn	VB
cord-015910-d9gxew91	552	25	against	against	IN
cord-015910-d9gxew91	552	26	the	the	DT
cord-015910-d9gxew91	552	27	body	body	NN
cord-015910-d9gxew91	552	28	,	,	,
cord-015910-d9gxew91	552	29	particularly	particularly	RB
cord-015910-d9gxew91	552	30	as	as	IN
cord-015910-d9gxew91	552	31	the	the	DT
cord-015910-d9gxew91	552	32	body	body	NN
cord-015910-d9gxew91	552	33	ages	age	NNS
cord-015910-d9gxew91	552	34	or	or	CC
cord-015910-d9gxew91	552	35	becomes	become	VBZ
cord-015910-d9gxew91	552	36	obese	obese	JJ
cord-015910-d9gxew91	552	37	.	.	.
cord-015910-d9gxew91	553	1	The	the	DT
cord-015910-d9gxew91	553	2	response	response	NN
cord-015910-d9gxew91	553	3	,	,	,
cord-015910-d9gxew91	553	4	which	which	WDT
cord-015910-d9gxew91	553	5	can	can	MD
cord-015910-d9gxew91	553	6	be	be	VB
cord-015910-d9gxew91	553	7	devastating	devastating	JJ
cord-015910-d9gxew91	553	8	when	when	WRB
cord-015910-d9gxew91	553	9	directed	direct	VBN
cord-015910-d9gxew91	553	10	against	against	IN
cord-015910-d9gxew91	553	11	microbes	microbe	NNS
cord-015910-d9gxew91	553	12	entering	enter	VBG
cord-015910-d9gxew91	553	13	the	the	DT
cord-015910-d9gxew91	553	14	body	body	NN
cord-015910-d9gxew91	553	15	,	,	,
cord-015910-d9gxew91	553	16	also	also	RB
cord-015910-d9gxew91	553	17	sows	sow	VBZ
cord-015910-d9gxew91	553	18	the	the	DT
cord-015910-d9gxew91	553	19	seeds	seed	NNS
cord-015910-d9gxew91	553	20	of	of	IN
cord-015910-d9gxew91	553	21	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	553	22	,	,	,
cord-015910-d9gxew91	553	23	degradation	degradation	NN
cord-015910-d9gxew91	553	24	of	of	IN
cord-015910-d9gxew91	553	25	brain	brain	NN
cord-015910-d9gxew91	553	26	function	function	NN
cord-015910-d9gxew91	553	27	,	,	,
cord-015910-d9gxew91	553	28	and	and	CC
cord-015910-d9gxew91	553	29	insulin	insulin	NN
cord-015910-d9gxew91	553	30	insensitivity	insensitivity	NN
cord-015910-d9gxew91	553	31	and	and	CC
cord-015910-d9gxew91	553	32	hastens	hasten	VBZ
cord-015910-d9gxew91	553	33	the	the	DT
cord-015910-d9gxew91	553	34	passage	passage	NN
cord-015910-d9gxew91	553	35	of	of	IN
cord-015910-d9gxew91	553	36	HIV	HIV	NNP
cord-015910-d9gxew91	553	37	-	-	HYPH
cord-015910-d9gxew91	553	38	infected	infect	VBN
cord-015910-d9gxew91	553	39	individuals	individual	NNS
cord-015910-d9gxew91	553	40	towards	towards	IN
cord-015910-d9gxew91	553	41	full	full	RB
cord-015910-d9gxew91	553	42	-	-	HYPH
cord-015910-d9gxew91	553	43	blown	blown	JJ
cord-015910-d9gxew91	553	44	AIDS	AIDS	NNP
cord-015910-d9gxew91	553	45	.	.	.
cord-015910-d9gxew91	554	1	Along	along	IN
cord-015910-d9gxew91	554	2	with	with	IN
cord-015910-d9gxew91	554	3	the	the	DT
cord-015910-d9gxew91	554	4	insights	insight	NNS
cord-015910-d9gxew91	554	5	arising	arise	VBG
cord-015910-d9gxew91	554	6	from	from	IN
cord-015910-d9gxew91	554	7	the	the	DT
cord-015910-d9gxew91	554	8	unraveling	unraveling	NN
cord-015910-d9gxew91	554	9	of	of	IN
cord-015910-d9gxew91	554	10	the	the	DT
cord-015910-d9gxew91	554	11	human	human	JJ
cord-015910-d9gxew91	554	12	genome	genome	NN
cord-015910-d9gxew91	554	13	has	have	VBZ
cord-015910-d9gxew91	554	14	come	come	VBN
cord-015910-d9gxew91	554	15	evidence	evidence	NN
cord-015910-d9gxew91	554	16	that	that	IN
cord-015910-d9gxew91	554	17	the	the	DT
cord-015910-d9gxew91	554	18	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	554	19	response	response	NN
cord-015910-d9gxew91	554	20	is	be	VBZ
cord-015910-d9gxew91	554	21	able	able	JJ
cord-015910-d9gxew91	554	22	to	to	TO
cord-015910-d9gxew91	554	23	protect	protect	VB
cord-015910-d9gxew91	554	24	the	the	DT
cord-015910-d9gxew91	554	25	human	human	JJ
cord-015910-d9gxew91	554	26	species	specie	NNS
cord-015910-d9gxew91	554	27	from	from	IN
cord-015910-d9gxew91	554	28	invasion	invasion	NN
cord-015910-d9gxew91	554	29	by	by	IN
cord-015910-d9gxew91	554	30	pathogens	pathogen	NNS
cord-015910-d9gxew91	554	31	but	but	CC
cord-015910-d9gxew91	554	32	not	not	RB
cord-015910-d9gxew91	554	33	all	all	DT
cord-015910-d9gxew91	554	34	individuals	individual	NNS
cord-015910-d9gxew91	554	35	within	within	IN
cord-015910-d9gxew91	554	36	the	the	DT
cord-015910-d9gxew91	554	37	species	specie	NNS
cord-015910-d9gxew91	554	38	from	from	IN
cord-015910-d9gxew91	554	39	ill	ill	JJ
cord-015910-d9gxew91	554	40	health	health	NN
cord-015910-d9gxew91	554	41	.	.	.
cord-015910-d9gxew91	555	1	The	the	DT
cord-015910-d9gxew91	555	2	differing	differ	VBG
cord-015910-d9gxew91	555	3	ability	ability	NN
cord-015910-d9gxew91	555	4	of	of	IN
cord-015910-d9gxew91	555	5	humans	human	NNS
cord-015910-d9gxew91	555	6	,	,	,
cord-015910-d9gxew91	555	7	particularly	particularly	RB
cord-015910-d9gxew91	555	8	the	the	DT
cord-015910-d9gxew91	555	9	male	male	NN
cord-015910-d9gxew91	555	10	of	of	IN
cord-015910-d9gxew91	555	11	the	the	DT
cord-015910-d9gxew91	555	12	species	specie	NNS
cord-015910-d9gxew91	555	13	,	,	,
cord-015910-d9gxew91	555	14	at	at	IN
cord-015910-d9gxew91	555	15	an	an	DT
cord-015910-d9gxew91	555	16	individual	individual	JJ
cord-015910-d9gxew91	555	17	level	level	NN
cord-015910-d9gxew91	555	18	to	to	TO
cord-015910-d9gxew91	555	19	mount	mount	VB
cord-015910-d9gxew91	555	20	an	an	DT
cord-015910-d9gxew91	555	21	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	555	22	response	response	NN
cord-015910-d9gxew91	555	23	of	of	IN
cord-015910-d9gxew91	555	24	different	different	JJ
cord-015910-d9gxew91	555	25	levels	level	NNS
cord-015910-d9gxew91	555	26	of	of	IN
cord-015910-d9gxew91	555	27	intensity	intensity	NN
cord-015910-d9gxew91	555	28	owing	owe	VBG
cord-015910-d9gxew91	555	29	to	to	IN
cord-015910-d9gxew91	555	30	genotype	genotype	NN
cord-015910-d9gxew91	555	31	can	can	MD
cord-015910-d9gxew91	555	32	result	result	VB
cord-015910-d9gxew91	555	33	in	in	IN
cord-015910-d9gxew91	555	34	widely	widely	RB
cord-015910-d9gxew91	555	35	contrasting	contrast	VBG
cord-015910-d9gxew91	555	36	outcomes	outcome	NNS
cord-015910-d9gxew91	555	37	of	of	IN
cord-015910-d9gxew91	555	38	invasion	invasion	NN
cord-015910-d9gxew91	555	39	of	of	IN
cord-015910-d9gxew91	555	40	the	the	DT
cord-015910-d9gxew91	555	41	body	body	NN
cord-015910-d9gxew91	555	42	by	by	IN
cord-015910-d9gxew91	555	43	pathogens	pathogen	NNS
cord-015910-d9gxew91	555	44	.	.	.
cord-015910-d9gxew91	556	1	On	on	IN
cord-015910-d9gxew91	556	2	the	the	DT
cord-015910-d9gxew91	556	3	one	one	CD
cord-015910-d9gxew91	556	4	hand	hand	NN
cord-015910-d9gxew91	556	5	,	,	,
cord-015910-d9gxew91	556	6	individuals	individual	NNS
cord-015910-d9gxew91	556	7	may	may	MD
cord-015910-d9gxew91	556	8	effectively	effectively	RB
cord-015910-d9gxew91	556	9	fight	fight	VB
cord-015910-d9gxew91	556	10	off	off	RP
cord-015910-d9gxew91	556	11	invasion	invasion	NN
cord-015910-d9gxew91	556	12	provided	provide	VBD
cord-015910-d9gxew91	556	13	the	the	DT
cord-015910-d9gxew91	556	14	immune	immune	JJ
cord-015910-d9gxew91	556	15	response	response	NN
cord-015910-d9gxew91	556	16	follows	follow	VBZ
cord-015910-d9gxew91	556	17	a	a	DT
cord-015910-d9gxew91	556	18	normal	normal	JJ
cord-015910-d9gxew91	556	19	pathway	pathway	NN
cord-015910-d9gxew91	556	20	,	,	,
cord-015910-d9gxew91	556	21	whereas	whereas	IN
cord-015910-d9gxew91	556	22	other	other	JJ
cord-015910-d9gxew91	556	23	individuals	individual	NNS
cord-015910-d9gxew91	556	24	within	within	IN
cord-015910-d9gxew91	556	25	the	the	DT
cord-015910-d9gxew91	556	26	same	same	JJ
cord-015910-d9gxew91	556	27	community	community	NN
cord-015910-d9gxew91	556	28	encoutering	encoutere	VBG
cord-015910-d9gxew91	556	29	the	the	DT
cord-015910-d9gxew91	556	30	same	same	JJ
cord-015910-d9gxew91	556	31	pathogens	pathogen	NNS
cord-015910-d9gxew91	556	32	will	will	MD
cord-015910-d9gxew91	556	33	die	die	VB
cord-015910-d9gxew91	556	34	from	from	IN
cord-015910-d9gxew91	556	35	the	the	DT
cord-015910-d9gxew91	556	36	strength	strength	NN
cord-015910-d9gxew91	556	37	and	and	CC
cord-015910-d9gxew91	556	38	nature	nature	NN
cord-015910-d9gxew91	556	39	of	of	IN
cord-015910-d9gxew91	556	40	the	the	DT
cord-015910-d9gxew91	556	41	response	response	NN
cord-015910-d9gxew91	556	42	rather	rather	RB
cord-015910-d9gxew91	556	43	than	than	IN
cord-015910-d9gxew91	556	44	from	from	IN
cord-015910-d9gxew91	556	45	the	the	DT
cord-015910-d9gxew91	556	46	direct	direct	JJ
cord-015910-d9gxew91	556	47	effects	effect	NNS
cord-015910-d9gxew91	556	48	of	of	IN
cord-015910-d9gxew91	556	49	the	the	DT
cord-015910-d9gxew91	556	50	invader	invader	NN
cord-015910-d9gxew91	556	51	.	.	.
cord-015910-d9gxew91	557	1	Insights	insight	NNS
cord-015910-d9gxew91	557	2	gained	gain	VBD
cord-015910-d9gxew91	557	3	from	from	IN
cord-015910-d9gxew91	557	4	the	the	DT
cord-015910-d9gxew91	557	5	genomic	genomic	JJ
cord-015910-d9gxew91	557	6	influences	influence	NNS
cord-015910-d9gxew91	557	7	on	on	IN
cord-015910-d9gxew91	557	8	cytokine	cytokine	NN
cord-015910-d9gxew91	557	9	production	production	NN
cord-015910-d9gxew91	557	10	and	and	CC
cord-015910-d9gxew91	557	11	the	the	DT
cord-015910-d9gxew91	557	12	response	response	NN
cord-015910-d9gxew91	557	13	to	to	IN
cord-015910-d9gxew91	557	14	malaria	malaria	NN
cord-015910-d9gxew91	557	15	suggest	suggest	VB
cord-015910-d9gxew91	557	16	that	that	IN
cord-015910-d9gxew91	557	17	the	the	DT
cord-015910-d9gxew91	557	18	retention	retention	NN
cord-015910-d9gxew91	557	19	of	of	IN
cord-015910-d9gxew91	557	20	alleles	allele	NNS
cord-015910-d9gxew91	557	21	in	in	IN
cord-015910-d9gxew91	557	22	pro	pro	JJ
cord-015910-d9gxew91	557	23	-	-	JJ
cord-015910-d9gxew91	557	24	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	557	25	cytokine	cytokine	NN
cord-015910-d9gxew91	557	26	genes	gene	NNS
cord-015910-d9gxew91	557	27	that	that	WDT
cord-015910-d9gxew91	557	28	resulted	result	VBD
cord-015910-d9gxew91	557	29	in	in	IN
cord-015910-d9gxew91	557	30	enhanced	enhanced	JJ
cord-015910-d9gxew91	557	31	cytokine	cytokine	NN
cord-015910-d9gxew91	557	32	production	production	NN
cord-015910-d9gxew91	557	33	within	within	IN
cord-015910-d9gxew91	557	34	the	the	DT
cord-015910-d9gxew91	557	35	human	human	JJ
cord-015910-d9gxew91	557	36	gene	gene	NN
cord-015910-d9gxew91	557	37	pool	pool	NN
cord-015910-d9gxew91	557	38	over	over	IN
cord-015910-d9gxew91	557	39	generations	generation	NNS
cord-015910-d9gxew91	557	40	could	could	MD
cord-015910-d9gxew91	557	41	be	be	VB
cord-015910-d9gxew91	557	42	a	a	DT
cord-015910-d9gxew91	557	43	result	result	NN
cord-015910-d9gxew91	557	44	of	of	IN
cord-015910-d9gxew91	557	45	the	the	DT
cord-015910-d9gxew91	557	46	heterozygotes	heterozygote	NNS
cord-015910-d9gxew91	557	47	'	'	POS
cord-015910-d9gxew91	557	48	better	well	JJR
cord-015910-d9gxew91	557	49	capacity	capacity	NN
cord-015910-d9gxew91	557	50	for	for	IN
cord-015910-d9gxew91	557	51	fighting	fighting	NN
cord-015910-d9gxew91	557	52	pathogens	pathogen	NNS
cord-015910-d9gxew91	557	53	,	,	,
cord-015910-d9gxew91	557	54	whereas	whereas	IN
cord-015910-d9gxew91	557	55	homozygotes	homozygote	NNS
cord-015910-d9gxew91	557	56	of	of	IN
cord-015910-d9gxew91	557	57	the	the	DT
cord-015910-d9gxew91	557	58	high	high	RB
cord-015910-d9gxew91	557	59	-	-	HYPH
cord-015910-d9gxew91	557	60	producing	produce	VBG
cord-015910-d9gxew91	557	61	genotype	genotype	NN
cord-015910-d9gxew91	557	62	run	run	VB
cord-015910-d9gxew91	557	63	an	an	DT
cord-015910-d9gxew91	557	64	increased	increase	VBN
cord-015910-d9gxew91	557	65	risk	risk	NN
cord-015910-d9gxew91	557	66	of	of	IN
cord-015910-d9gxew91	557	67	a	a	DT
cord-015910-d9gxew91	557	68	strong	strong	JJ
cord-015910-d9gxew91	557	69	adverse	adverse	JJ
cord-015910-d9gxew91	557	70	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	557	71	response	response	NN
cord-015910-d9gxew91	557	72	.	.	.
cord-015910-d9gxew91	558	1	In	in	IN
cord-015910-d9gxew91	558	2	the	the	DT
cord-015910-d9gxew91	558	3	case	case	NN
cord-015910-d9gxew91	558	4	of	of	IN
cord-015910-d9gxew91	558	5	sickle	sickle	NN
cord-015910-d9gxew91	558	6	cell	cell	NN
cord-015910-d9gxew91	558	7	anemia	anemia	NN
cord-015910-d9gxew91	558	8	,	,	,
cord-015910-d9gxew91	558	9	where	where	WRB
cord-015910-d9gxew91	558	10	heterozygotic	heterozygotic	JJ
cord-015910-d9gxew91	558	11	individuals	individual	NNS
cord-015910-d9gxew91	558	12	reap	reap	VBP
cord-015910-d9gxew91	558	13	an	an	DT
cord-015910-d9gxew91	558	14	advantage	advantage	NN
cord-015910-d9gxew91	558	15	in	in	IN
cord-015910-d9gxew91	558	16	resistance	resistance	NN
cord-015910-d9gxew91	558	17	to	to	IN
cord-015910-d9gxew91	558	18	malaria	malaria	NN
cord-015910-d9gxew91	558	19	by	by	IN
cord-015910-d9gxew91	558	20	possession	possession	NN
cord-015910-d9gxew91	558	21	of	of	IN
cord-015910-d9gxew91	558	22	only	only	RB
cord-015910-d9gxew91	558	23	one	one	CD
cord-015910-d9gxew91	558	24	copy	copy	NN
cord-015910-d9gxew91	558	25	of	of	IN
cord-015910-d9gxew91	558	26	the	the	DT
cord-015910-d9gxew91	558	27	anemia	anemia	NN
cord-015910-d9gxew91	558	28	allele	allele	NN
cord-015910-d9gxew91	558	29	,	,	,
cord-015910-d9gxew91	558	30	homozygous	homozygous	JJ
cord-015910-d9gxew91	558	31	individuals	individual	NNS
cord-015910-d9gxew91	558	32	for	for	IN
cord-015910-d9gxew91	558	33	the	the	DT
cord-015910-d9gxew91	558	34	sickle	sickle	NN
cord-015910-d9gxew91	558	35	cell	cell	NN
cord-015910-d9gxew91	558	36	trait	trait	NN
cord-015910-d9gxew91	558	37	pay	pay	VBP
cord-015910-d9gxew91	558	38	the	the	DT
cord-015910-d9gxew91	558	39	price	price	NN
cord-015910-d9gxew91	558	40	for	for	IN
cord-015910-d9gxew91	558	41	possession	possession	NN
cord-015910-d9gxew91	558	42	of	of	IN
cord-015910-d9gxew91	558	43	two	two	CD
cord-015910-d9gxew91	558	44	copies	copy	NNS
cord-015910-d9gxew91	558	45	of	of	IN
cord-015910-d9gxew91	558	46	the	the	DT
cord-015910-d9gxew91	558	47	allele	allele	NN
cord-015910-d9gxew91	558	48	and	and	CC
cord-015910-d9gxew91	558	49	die	die	VBP
cord-015910-d9gxew91	558	50	young	young	JJ
cord-015910-d9gxew91	558	51	.	.	.
cord-015910-d9gxew91	559	1	Because	because	IN
cord-015910-d9gxew91	559	2	of	of	IN
cord-015910-d9gxew91	559	3	the	the	DT
cord-015910-d9gxew91	559	4	overall	overall	JJ
cord-015910-d9gxew91	559	5	advantage	advantage	NN
cord-015910-d9gxew91	559	6	of	of	IN
cord-015910-d9gxew91	559	7	this	this	DT
cord-015910-d9gxew91	559	8	situation	situation	NN
cord-015910-d9gxew91	559	9	to	to	IN
cord-015910-d9gxew91	559	10	the	the	DT
cord-015910-d9gxew91	559	11	species	specie	NNS
cord-015910-d9gxew91	559	12	,	,	,
cord-015910-d9gxew91	559	13	the	the	DT
cord-015910-d9gxew91	559	14	potentially	potentially	RB
cord-015910-d9gxew91	559	15	disadvantageous	disadvantageous	JJ
cord-015910-d9gxew91	559	16	allele	allele	NN
cord-015910-d9gxew91	559	17	will	will	MD
cord-015910-d9gxew91	559	18	be	be	VB
cord-015910-d9gxew91	559	19	retained	retain	VBN
cord-015910-d9gxew91	559	20	within	within	IN
cord-015910-d9gxew91	559	21	the	the	DT
cord-015910-d9gxew91	559	22	human	human	JJ
cord-015910-d9gxew91	559	23	gene	gene	NN
cord-015910-d9gxew91	559	24	pool	pool	NN
cord-015910-d9gxew91	559	25	over	over	IN
cord-015910-d9gxew91	559	26	generations	generation	NNS
cord-015910-d9gxew91	559	27	.	.	.
cord-015910-d9gxew91	560	1	With	with	IN
cord-015910-d9gxew91	560	2	the	the	DT
cord-015910-d9gxew91	560	3	twin	twin	JJ
cord-015910-d9gxew91	560	4	discoveries	discovery	NNS
cord-015910-d9gxew91	560	5	that	that	WDT
cord-015910-d9gxew91	560	6	nutrients	nutrient	NNS
cord-015910-d9gxew91	560	7	can	can	MD
cord-015910-d9gxew91	560	8	modulate	modulate	VB
cord-015910-d9gxew91	560	9	the	the	DT
cord-015910-d9gxew91	560	10	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	560	11	response	response	NN
cord-015910-d9gxew91	560	12	and	and	CC
cord-015910-d9gxew91	560	13	that	that	IN
cord-015910-d9gxew91	560	14	cytokine	cytokine	NN
cord-015910-d9gxew91	560	15	genotype	genotype	NN
cord-015910-d9gxew91	560	16	can	can	MD
cord-015910-d9gxew91	560	17	modulate	modulate	VB
cord-015910-d9gxew91	560	18	the	the	DT
cord-015910-d9gxew91	560	19	effectiveness	effectiveness	NN
cord-015910-d9gxew91	560	20	of	of	IN
cord-015910-d9gxew91	560	21	nutrients	nutrient	NNS
cord-015910-d9gxew91	560	22	in	in	IN
cord-015910-d9gxew91	560	23	controlling	control	VBG
cord-015910-d9gxew91	560	24	inflammation	inflammation	NN
cord-015910-d9gxew91	560	25	,	,	,
cord-015910-d9gxew91	560	26	nutritional	nutritional	JJ
cord-015910-d9gxew91	560	27	science	science	NN
cord-015910-d9gxew91	560	28	sits	sit	VBZ
cord-015910-d9gxew91	560	29	at	at	IN
cord-015910-d9gxew91	560	30	an	an	DT
cord-015910-d9gxew91	560	31	exciting	exciting	JJ
cord-015910-d9gxew91	560	32	moment	moment	NN
cord-015910-d9gxew91	560	33	in	in	IN
cord-015910-d9gxew91	560	34	its	-PRON-	PRP$
cord-015910-d9gxew91	560	35	development	development	NN
cord-015910-d9gxew91	560	36	.	.	.
cord-015910-d9gxew91	561	1	The	the	DT
cord-015910-d9gxew91	561	2	mapping	mapping	NN
cord-015910-d9gxew91	561	3	of	of	IN
cord-015910-d9gxew91	561	4	how	how	WRB
cord-015910-d9gxew91	561	5	pro	pro	JJ
cord-015910-d9gxew91	561	6	-	-	JJ
cord-015910-d9gxew91	561	7	and	and	CC
cord-015910-d9gxew91	561	8	anti	anti	JJ
cord-015910-d9gxew91	561	9	-	-	JJ
cord-015910-d9gxew91	561	10	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	561	11	cytokine	cytokine	NN
cord-015910-d9gxew91	561	12	genotypes	genotype	NNS
cord-015910-d9gxew91	561	13	interact	interact	VBP
cord-015910-d9gxew91	561	14	with	with	IN
cord-015910-d9gxew91	561	15	responsiveness	responsiveness	NN
cord-015910-d9gxew91	561	16	to	to	IN
cord-015910-d9gxew91	561	17	immunonutrients	immunonutrient	NNS
cord-015910-d9gxew91	561	18	at	at	IN
cord-015910-d9gxew91	561	19	an	an	DT
cord-015910-d9gxew91	561	20	indivividual	indivividual	JJ
cord-015910-d9gxew91	561	21	level	level	NN
cord-015910-d9gxew91	561	22	will	will	MD
cord-015910-d9gxew91	561	23	allow	allow	VB
cord-015910-d9gxew91	561	24	tailor	tailor	NN
cord-015910-d9gxew91	561	25	-	-	HYPH
cord-015910-d9gxew91	561	26	made	make	VBN
cord-015910-d9gxew91	561	27	nutritional	nutritional	JJ
cord-015910-d9gxew91	561	28	treatments	treatment	NNS
cord-015910-d9gxew91	561	29	of	of	IN
cord-015910-d9gxew91	561	30	all	all	DT
cord-015910-d9gxew91	561	31	diseases	disease	NNS
cord-015910-d9gxew91	561	32	that	that	WDT
cord-015910-d9gxew91	561	33	have	have	VBP
cord-015910-d9gxew91	561	34	an	an	DT
cord-015910-d9gxew91	561	35	underlying	underlying	JJ
cord-015910-d9gxew91	561	36	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	561	37	basis	basis	NN
cord-015910-d9gxew91	561	38	.	.	.
cord-015910-d9gxew91	562	1	Furthermore	furthermore	RB
cord-015910-d9gxew91	562	2	,	,	,
cord-015910-d9gxew91	562	3	a	a	DT
cord-015910-d9gxew91	562	4	better	well	JJR
cord-015910-d9gxew91	562	5	understanding	understanding	NN
cord-015910-d9gxew91	562	6	of	of	IN
cord-015910-d9gxew91	562	7	how	how	WRB
cord-015910-d9gxew91	562	8	nutritonal	nutritonal	JJ
cord-015910-d9gxew91	562	9	therapies	therapy	NNS
cord-015910-d9gxew91	562	10	and	and	CC
cord-015910-d9gxew91	562	11	genetics	genetic	NNS
cord-015910-d9gxew91	562	12	interact	interact	VBP
cord-015910-d9gxew91	562	13	will	will	MD
cord-015910-d9gxew91	562	14	allow	allow	VB
cord-015910-d9gxew91	562	15	the	the	DT
cord-015910-d9gxew91	562	16	twin	twin	JJ
cord-015910-d9gxew91	562	17	adverse	adverse	JJ
cord-015910-d9gxew91	562	18	biological	biological	JJ
cord-015910-d9gxew91	562	19	factors	factor	NNS
cord-015910-d9gxew91	562	20	increasing	increase	VBG
cord-015910-d9gxew91	562	21	the	the	DT
cord-015910-d9gxew91	562	22	level	level	NN
cord-015910-d9gxew91	562	23	of	of	IN
cord-015910-d9gxew91	562	24	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	562	25	stress	stress	NN
cord-015910-d9gxew91	562	26	in	in	IN
cord-015910-d9gxew91	562	27	populations	population	NNS
cord-015910-d9gxew91	562	28	---	---	:
cord-015910-d9gxew91	562	29	obesity	obesity	NN
cord-015910-d9gxew91	562	30	and	and	CC
cord-015910-d9gxew91	562	31	aging	aging	NN
cord-015910-d9gxew91	562	32	--	--	:
cord-015910-d9gxew91	562	33	to	to	TO
cord-015910-d9gxew91	562	34	be	be	VB
cord-015910-d9gxew91	562	35	tackled	tackle	VBN
cord-015910-d9gxew91	562	36	by	by	IN
cord-015910-d9gxew91	562	37	targeted	target	VBN
cord-015910-d9gxew91	562	38	nutritional	nutritional	JJ
cord-015910-d9gxew91	562	39	therapy	therapy	NN
cord-015910-d9gxew91	562	40	.	.	.
cord-015910-d9gxew91	563	1	The	the	DT
cord-015910-d9gxew91	563	2	roles	role	NNS
cord-015910-d9gxew91	563	3	of	of	IN
cord-015910-d9gxew91	563	4	Nramp	Nramp	NNP
cord-015910-d9gxew91	563	5	1	1	CD
cord-015910-d9gxew91	563	6	and	and	CC
cord-015910-d9gxew91	563	7	Tnfo~	Tnfo~	NNP
cord-015910-d9gxew91	563	8	genes	gene	NNS
cord-015910-d9gxew91	563	9	in	in	IN
cord-015910-d9gxew91	563	10	nitric	nitric	NN
cord-015910-d9gxew91	563	11	oxide	oxide	NN
cord-015910-d9gxew91	563	12	production	production	NN
cord-015910-d9gxew91	563	13	and	and	CC
cord-015910-d9gxew91	563	14	their	-PRON-	PRP$
cord-015910-d9gxew91	563	15	effect	effect	NN
cord-015910-d9gxew91	563	16	on	on	IN
cord-015910-d9gxew91	563	17	the	the	DT
cord-015910-d9gxew91	563	18	growth	growth	NN
cord-015910-d9gxew91	563	19	of	of	IN
cord-015910-d9gxew91	563	20	Salmonella	Salmonella	NNP
cord-015910-d9gxew91	563	21	typhimurium	typhimurium	NN
cord-015910-d9gxew91	563	22	in	in	IN
cord-015910-d9gxew91	563	23	macrophages	macrophage	NNS
cord-015910-d9gxew91	563	24	from	from	IN
cord-015910-d9gxew91	563	25	Nrampl	Nrampl	NNP
cord-015910-d9gxew91	563	26	congenic	congenic	NN
cord-015910-d9gxew91	563	27	and	and	CC
cord-015910-d9gxew91	563	28	tumor	tumor	NN
cord-015910-d9gxew91	563	29	necrosis	necrosis	NN
cord-015910-d9gxew91	563	30	factor	factor	NN
cord-015910-d9gxew91	563	31	-	-	HYPH
cord-015910-d9gxew91	563	32	alpha-/-mice	alpha-/-mice	CD
cord-015910-d9gxew91	563	33	Polymorphism	polymorphism	NN
cord-015910-d9gxew91	563	34	of	of	IN
cord-015910-d9gxew91	563	35	the	the	DT
cord-015910-d9gxew91	563	36	human	human	JJ
cord-015910-d9gxew91	563	37	TNF	TNF	NNP
cord-015910-d9gxew91	563	38	-	-	HYPH
cord-015910-d9gxew91	563	39	cz	cz	NNP
cord-015910-d9gxew91	563	40	promoter	promoter	NN
cord-015910-d9gxew91	563	41	--	--	:
cord-015910-d9gxew91	563	42	random	random	JJ
cord-015910-d9gxew91	563	43	variation	variation	NN
cord-015910-d9gxew91	563	44	or	or	CC
cord-015910-d9gxew91	563	45	functional	functional	JJ
cord-015910-d9gxew91	563	46	diversity	diversity	NN
cord-015910-d9gxew91	563	47	?	?	.
cord-015910-d9gxew91	564	1	Molecular	molecular	JJ
cord-015910-d9gxew91	564	2	Immunolology	Immunolology	NNP
cord-015910-d9gxew91	564	3	Periodontal	periodontal	JJ
cord-015910-d9gxew91	564	4	infections	infection	NNS
cord-015910-d9gxew91	564	5	and	and	CC
cord-015910-d9gxew91	564	6	cardiovascular	cardiovascular	JJ
cord-015910-d9gxew91	564	7	disease	disease	NN
cord-015910-d9gxew91	565	1	--how	--how	:
cord-015910-d9gxew91	565	2	strong	strong	JJ
cord-015910-d9gxew91	565	3	is	be	VBZ
cord-015910-d9gxew91	565	4	the	the	DT
cord-015910-d9gxew91	565	5	association	association	NN
cord-015910-d9gxew91	565	6	?	?	.
cord-015910-d9gxew91	566	1	Oral	oral	JJ
cord-015910-d9gxew91	566	2	Disease	Disease	NNP
cord-015910-d9gxew91	566	3	Predictive	Predictive	NNP
cord-015910-d9gxew91	566	4	value	value	NN
cord-015910-d9gxew91	566	5	of	of	IN
cord-015910-d9gxew91	566	6	nuclear	nuclear	JJ
cord-015910-d9gxew91	566	7	factor	factor	NN
cord-015910-d9gxew91	566	8	kappaB	kappaB	NNP
cord-015910-d9gxew91	566	9	activity	activity	NN
cord-015910-d9gxew91	566	10	and	and	CC
cord-015910-d9gxew91	566	11	plasma	plasma	NN
cord-015910-d9gxew91	566	12	cytokine	cytokine	NN
cord-015910-d9gxew91	566	13	levels	level	NNS
cord-015910-d9gxew91	566	14	in	in	IN
cord-015910-d9gxew91	566	15	patients	patient	NNS
cord-015910-d9gxew91	566	16	with	with	IN
cord-015910-d9gxew91	566	17	sepsis	sepsis	NN
cord-015910-d9gxew91	566	18	Vitamin	vitamin	NN
cord-015910-d9gxew91	566	19	E	e	NN
cord-015910-d9gxew91	566	20	:	:	:
cord-015910-d9gxew91	567	1	A	a	DT
cord-015910-d9gxew91	567	2	sensor	sensor	NN
cord-015910-d9gxew91	567	3	and	and	CC
cord-015910-d9gxew91	567	4	an	an	DT
cord-015910-d9gxew91	567	5	information	information	NN
cord-015910-d9gxew91	567	6	transducer	transducer	NN
cord-015910-d9gxew91	567	7	of	of	IN
cord-015910-d9gxew91	567	8	the	the	DT
cord-015910-d9gxew91	567	9	cell	cell	NN
cord-015910-d9gxew91	567	10	oxidation	oxidation	NN
cord-015910-d9gxew91	567	11	state	state	NN
cord-015910-d9gxew91	567	12	Lipoprotein(a	Lipoprotein(a	NNP
cord-015910-d9gxew91	567	13	)	)	-RRB-
cord-015910-d9gxew91	567	14	and	and	CC
cord-015910-d9gxew91	567	15	lipoprotein	lipoprotein	NN
cord-015910-d9gxew91	567	16	profile	profile	NN
cord-015910-d9gxew91	567	17	in	in	IN
cord-015910-d9gxew91	567	18	healthy	healthy	JJ
cord-015910-d9gxew91	567	19	centenarians	centenarian	NNS
cord-015910-d9gxew91	567	20	:	:	:
cord-015910-d9gxew91	567	21	A	a	DT
cord-015910-d9gxew91	567	22	reappraisal	reappraisal	NN
cord-015910-d9gxew91	567	23	of	of	IN
cord-015910-d9gxew91	567	24	vascular	vascular	JJ
cord-015910-d9gxew91	567	25	risk	risk	NN
cord-015910-d9gxew91	567	26	factors	factor	NNS
cord-015910-d9gxew91	567	27	Immunonutrition	Immunonutrition	NNP
cord-015910-d9gxew91	567	28	in	in	IN
cord-015910-d9gxew91	567	29	the	the	DT
cord-015910-d9gxew91	567	30	critically	critically	RB
cord-015910-d9gxew91	567	31	ill	ill	JJ
cord-015910-d9gxew91	567	32	:	:	:
cord-015910-d9gxew91	567	33	A	a	DT
cord-015910-d9gxew91	567	34	systematic	systematic	JJ
cord-015910-d9gxew91	567	35	review	review	NN
cord-015910-d9gxew91	567	36	of	of	IN
cord-015910-d9gxew91	567	37	clinical	clinical	JJ
cord-015910-d9gxew91	567	38	outcome	outcome	NN
cord-015910-d9gxew91	567	39	Inflammation	inflammation	NN
cord-015910-d9gxew91	567	40	,	,	,
cord-015910-d9gxew91	567	41	insulin	insulin	NN
cord-015910-d9gxew91	567	42	resistance	resistance	NN
cord-015910-d9gxew91	567	43	,	,	,
cord-015910-d9gxew91	567	44	infection	infection	NN
cord-015910-d9gxew91	567	45	,	,	,
cord-015910-d9gxew91	567	46	diabetes	diabetes	NN
cord-015910-d9gxew91	567	47	,	,	,
cord-015910-d9gxew91	567	48	and	and	CC
cord-015910-d9gxew91	567	49	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	567	50	.	.	.
cord-015910-d9gxew91	568	1	Endocrinological	Endocrinological	NNP
cord-015910-d9gxew91	568	2	Practice	practice	VBP
cord-015910-d9gxew91	569	1	Interleukin-6	Interleukin-6	NNP
cord-015910-d9gxew91	569	2	is	be	VBZ
cord-015910-d9gxew91	569	3	an	an	DT
cord-015910-d9gxew91	569	4	essential	essential	JJ
cord-015910-d9gxew91	569	5	,	,	,
cord-015910-d9gxew91	569	6	corticotropin	corticotropin	NNP
cord-015910-d9gxew91	569	7	-	-	HYPH
cord-015910-d9gxew91	569	8	releasing	release	VBG
cord-015910-d9gxew91	569	9	hormone	hormone	NN
cord-015910-d9gxew91	569	10	-	-	HYPH
cord-015910-d9gxew91	569	11	independent	independent	JJ
cord-015910-d9gxew91	569	12	stimula	stimula	NNP
cord-015910-d9gxew91	569	13	-	-	:
cord-015910-d9gxew91	569	14	torof	torof	NNP
cord-015910-d9gxew91	569	15	the	the	DT
cord-015910-d9gxew91	569	16	adrenal	adrenal	JJ
cord-015910-d9gxew91	569	17	axis	axis	NN
cord-015910-d9gxew91	569	18	during	during	IN
cord-015910-d9gxew91	569	19	immune	immune	JJ
cord-015910-d9gxew91	569	20	system	system	NN
cord-015910-d9gxew91	569	21	activation	activation	NN
cord-015910-d9gxew91	569	22	Cytokine	cytokine	NN
cord-015910-d9gxew91	569	23	gene	gene	NN
cord-015910-d9gxew91	569	24	polymorphism	polymorphism	NN
cord-015910-d9gxew91	569	25	in	in	IN
cord-015910-d9gxew91	569	26	human	human	JJ
cord-015910-d9gxew91	569	27	disease	disease	NN
cord-015910-d9gxew91	569	28	:	:	:
cord-015910-d9gxew91	569	29	Online	online	JJ
cord-015910-d9gxew91	569	30	databases	database	NNS
cord-015910-d9gxew91	569	31	,	,	.
cord-015910-d9gxew91	570	1	supplement	supplement	NN
cord-015910-d9gxew91	570	2	1	1	CD
cord-015910-d9gxew91	570	3	A	a	DT
cord-015910-d9gxew91	570	4	gender	gender	NN
cord-015910-d9gxew91	570	5	-	-	HYPH
cord-015910-d9gxew91	570	6	dependent	dependent	JJ
cord-015910-d9gxew91	570	7	genetic	genetic	JJ
cord-015910-d9gxew91	570	8	predisposition	predisposition	NN
cord-015910-d9gxew91	570	9	to	to	TO
cord-015910-d9gxew91	570	10	produce	produce	VB
cord-015910-d9gxew91	570	11	high	high	JJ
cord-015910-d9gxew91	570	12	levels	level	NNS
cord-015910-d9gxew91	570	13	of	of	IN
cord-015910-d9gxew91	571	1	IL-6	IL-6	NNP
cord-015910-d9gxew91	571	2	is	be	VBZ
cord-015910-d9gxew91	571	3	detrimental	detrimental	JJ
cord-015910-d9gxew91	571	4	to	to	IN
cord-015910-d9gxew91	571	5	longevity	longevity	NN
cord-015910-d9gxew91	571	6	Impaired	impair	VBN
cord-015910-d9gxew91	571	7	glucose	glucose	NN
cord-015910-d9gxew91	571	8	tolerance	tolerance	NN
cord-015910-d9gxew91	571	9	,	,	,
cord-015910-d9gxew91	571	10	type	type	NN
cord-015910-d9gxew91	571	11	2	2	CD
cord-015910-d9gxew91	571	12	diabetes	diabetes	NN
cord-015910-d9gxew91	571	13	mellitus	mellitus	NN
cord-015910-d9gxew91	571	14	and	and	CC
cord-015910-d9gxew91	571	15	carotid	carotid	JJ
cord-015910-d9gxew91	571	16	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	571	17	:	:	:
cord-015910-d9gxew91	572	1	Prospective	prospective	JJ
cord-015910-d9gxew91	572	2	results	result	NNS
cord-015910-d9gxew91	572	3	of	of	IN
cord-015910-d9gxew91	572	4	the	the	DT
cord-015910-d9gxew91	572	5	Bruneck	Bruneck	NNP
cord-015910-d9gxew91	572	6	Study	Study	NNP
cord-015910-d9gxew91	572	7	Antioxidant	Antioxidant	NNP
cord-015910-d9gxew91	572	8	status	status	NN
cord-015910-d9gxew91	572	9	and	and	CC
cord-015910-d9gxew91	572	10	glutathione	glutathione	NN
cord-015910-d9gxew91	572	11	metabolism	metabolism	NN
cord-015910-d9gxew91	572	12	in	in	IN
cord-015910-d9gxew91	572	13	peripheral	peripheral	JJ
cord-015910-d9gxew91	572	14	blood	blood	NN
cord-015910-d9gxew91	572	15	mononuclear	mononuclear	NN
cord-015910-d9gxew91	572	16	cells	cell	NNS
cord-015910-d9gxew91	572	17	from	from	IN
cord-015910-d9gxew91	572	18	patients	patient	NNS
cord-015910-d9gxew91	572	19	with	with	IN
cord-015910-d9gxew91	572	20	chronic	chronic	JJ
cord-015910-d9gxew91	572	21	hepatitis	hepatitis	NN
cord-015910-d9gxew91	572	22	C	c	NN
cord-015910-d9gxew91	572	23	Improvement	improvement	NN
cord-015910-d9gxew91	572	24	of	of	IN
cord-015910-d9gxew91	572	25	immune	immune	JJ
cord-015910-d9gxew91	572	26	functions	function	NNS
cord-015910-d9gxew91	572	27	in	in	IN
cord-015910-d9gxew91	572	28	HIV	HIV	NNP
cord-015910-d9gxew91	572	29	infection	infection	NN
cord-015910-d9gxew91	572	30	by	by	IN
cord-015910-d9gxew91	572	31	sulfur	sulfur	NN
cord-015910-d9gxew91	572	32	supplementation	supplementation	NN
cord-015910-d9gxew91	572	33	:	:	:
cord-015910-d9gxew91	572	34	Two	two	CD
cord-015910-d9gxew91	572	35	randomized	randomized	JJ
cord-015910-d9gxew91	572	36	trials	trial	NNS
cord-015910-d9gxew91	572	37	A	a	DT
cord-015910-d9gxew91	572	38	short	short	JJ
cord-015910-d9gxew91	572	39	history	history	NN
cord-015910-d9gxew91	572	40	of	of	IN
cord-015910-d9gxew91	572	41	nearly	nearly	RB
cord-015910-d9gxew91	572	42	everything	everything	NN
cord-015910-d9gxew91	572	43	n-3	n-3	NN
cord-015910-d9gxew91	572	44	Polyunsaturated	polyunsaturated	JJ
cord-015910-d9gxew91	572	45	fatty	fatty	JJ
cord-015910-d9gxew91	572	46	acids	acid	NNS
cord-015910-d9gxew91	572	47	and	and	CC
cord-015910-d9gxew91	572	48	cytokine	cytokine	NN
cord-015910-d9gxew91	572	49	production	production	NN
cord-015910-d9gxew91	572	50	in	in	IN
cord-015910-d9gxew91	572	51	health	health	NN
cord-015910-d9gxew91	572	52	and	and	CC
cord-015910-d9gxew91	572	53	disease	disease	NN
cord-015910-d9gxew91	572	54	Glutamine	glutamine	NN
cord-015910-d9gxew91	573	1	enhances	enhance	VBZ
cord-015910-d9gxew91	573	2	gut	gut	NN
cord-015910-d9gxew91	573	3	glutathione	glutathione	NN
cord-015910-d9gxew91	573	4	production	production	NN
cord-015910-d9gxew91	573	5	Immunogenetics	immunogenetic	NNS
cord-015910-d9gxew91	573	6	of	of	IN
cord-015910-d9gxew91	573	7	longevity	longevity	NN
cord-015910-d9gxew91	573	8	.	.	.
cord-015910-d9gxew91	574	1	Is	be	VBZ
cord-015910-d9gxew91	574	2	major	major	JJ
cord-015910-d9gxew91	574	3	histocompatibility	histocompatibility	NN
cord-015910-d9gxew91	574	4	complex	complex	NN
cord-015910-d9gxew91	574	5	polymorphism	polymorphism	NN
cord-015910-d9gxew91	574	6	relevant	relevant	JJ
cord-015910-d9gxew91	574	7	to	to	IN
cord-015910-d9gxew91	574	8	the	the	DT
cord-015910-d9gxew91	574	9	control	control	NN
cord-015910-d9gxew91	574	10	of	of	IN
cord-015910-d9gxew91	574	11	human	human	JJ
cord-015910-d9gxew91	574	12	longevity	longevity	NN
cord-015910-d9gxew91	574	13	?	?	.
cord-015910-d9gxew91	575	1	A	a	DT
cord-015910-d9gxew91	575	2	review	review	NN
cord-015910-d9gxew91	575	3	of	of	IN
cord-015910-d9gxew91	575	4	literature	literature	NN
cord-015910-d9gxew91	575	5	data	datum	NNS
cord-015910-d9gxew91	575	6	C	c	NN
cord-015910-d9gxew91	575	7	-	-	HYPH
cord-015910-d9gxew91	575	8	reactive	reactive	JJ
cord-015910-d9gxew91	575	9	protein	protein	NN
cord-015910-d9gxew91	575	10	,	,	,
cord-015910-d9gxew91	575	11	insulin	insulin	NN
cord-015910-d9gxew91	575	12	resistance	resistance	NN
cord-015910-d9gxew91	575	13	,	,	,
cord-015910-d9gxew91	575	14	central	central	JJ
cord-015910-d9gxew91	575	15	obesity	obesity	NN
cord-015910-d9gxew91	575	16	,	,	,
cord-015910-d9gxew91	575	17	and	and	CC
cord-015910-d9gxew91	575	18	coronary	coronary	JJ
cord-015910-d9gxew91	575	19	heart	heart	NN
cord-015910-d9gxew91	575	20	disease	disease	NN
cord-015910-d9gxew91	575	21	risk	risk	NN
cord-015910-d9gxew91	575	22	in	in	IN
cord-015910-d9gxew91	575	23	Indian	Indian	NNP
cord-015910-d9gxew91	575	24	Asians	Asians	NNPS
cord-015910-d9gxew91	575	25	from	from	IN
cord-015910-d9gxew91	575	26	the	the	DT
cord-015910-d9gxew91	575	27	United	United	NNP
cord-015910-d9gxew91	575	28	Kingdom	Kingdom	NNP
cord-015910-d9gxew91	575	29	compared	compare	VBN
cord-015910-d9gxew91	575	30	with	with	IN
cord-015910-d9gxew91	575	31	European	european	JJ
cord-015910-d9gxew91	575	32	whites	white	NNS
cord-015910-d9gxew91	575	33	A	a	DT
cord-015910-d9gxew91	575	34	randomized	randomized	JJ
cord-015910-d9gxew91	575	35	,	,	,
cord-015910-d9gxew91	575	36	controlled	control	VBN
cord-015910-d9gxew91	575	37	trial	trial	NN
cord-015910-d9gxew91	575	38	of	of	IN
cord-015910-d9gxew91	575	39	IL-10	IL-10	NNP
cord-015910-d9gxew91	575	40	in	in	IN
cord-015910-d9gxew91	575	41	humans	human	NNS
cord-015910-d9gxew91	575	42	.	.	.
cord-015910-d9gxew91	576	1	Inhibition	inhibition	NN
cord-015910-d9gxew91	576	2	of	of	IN
cord-015910-d9gxew91	576	3	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	576	4	cytokine	cytokine	NN
cord-015910-d9gxew91	576	5	production	production	NN
cord-015910-d9gxew91	576	6	and	and	CC
cord-015910-d9gxew91	576	7	immune	immune	JJ
cord-015910-d9gxew91	576	8	responses	response	NNS
cord-015910-d9gxew91	577	1	Glutathione	glutathione	NN
cord-015910-d9gxew91	577	2	peroxidase	peroxidase	NN
cord-015910-d9gxew91	577	3	in	in	IN
cord-015910-d9gxew91	577	4	rheumatoid	rheumatoid	NN
cord-015910-d9gxew91	577	5	arthritis	arthritis	NN
cord-015910-d9gxew91	577	6	:	:	:
cord-015910-d9gxew91	577	7	Analysis	analysis	NN
cord-015910-d9gxew91	577	8	of	of	IN
cord-015910-d9gxew91	577	9	enzyme	enzyme	NN
cord-015910-d9gxew91	577	10	activity	activity	NN
cord-015910-d9gxew91	577	11	and	and	CC
cord-015910-d9gxew91	577	12	DNA	dna	NN
cord-015910-d9gxew91	577	13	polymorphism	polymorphism	NN
cord-015910-d9gxew91	577	14	Prostaglandin	prostaglandin	NN
cord-015910-d9gxew91	577	15	-	-	HYPH
cord-015910-d9gxew91	577	16	E2	E2	NNP
cord-015910-d9gxew91	577	17	regulation	regulation	NN
cord-015910-d9gxew91	577	18	of	of	IN
cord-015910-d9gxew91	577	19	tumor	tumor	NN
cord-015910-d9gxew91	577	20	necrosis	necrosis	NN
cord-015910-d9gxew91	577	21	factor	factor	NN
cord-015910-d9gxew91	577	22	receptor	receptor	NN
cord-015910-d9gxew91	577	23	release	release	NN
cord-015910-d9gxew91	577	24	in	in	IN
cord-015910-d9gxew91	577	25	human	human	JJ
cord-015910-d9gxew91	577	26	monocytic	monocytic	NNP
cord-015910-d9gxew91	577	27	THP-1	THP-1	NNP
cord-015910-d9gxew91	577	28	cells	cell	NNS
cord-015910-d9gxew91	577	29	Plasma	plasma	NN
cord-015910-d9gxew91	577	30	insulin	insulin	NN
cord-015910-d9gxew91	577	31	,	,	,
cord-015910-d9gxew91	577	32	leptin	leptin	NN
cord-015910-d9gxew91	577	33	,	,	,
cord-015910-d9gxew91	577	34	and	and	CC
cord-015910-d9gxew91	577	35	soluble	soluble	JJ
cord-015910-d9gxew91	577	36	TNF	TNF	NNP
cord-015910-d9gxew91	577	37	receptors	receptor	NNS
cord-015910-d9gxew91	577	38	levels	level	NNS
cord-015910-d9gxew91	577	39	in	in	IN
cord-015910-d9gxew91	577	40	relation	relation	NN
cord-015910-d9gxew91	577	41	to	to	IN
cord-015910-d9gxew91	577	42	obesity	obesity	NN
cord-015910-d9gxew91	577	43	-	-	HYPH
cord-015910-d9gxew91	577	44	related	relate	VBN
cord-015910-d9gxew91	577	45	atherogenic	atherogenic	JJ
cord-015910-d9gxew91	577	46	and	and	CC
cord-015910-d9gxew91	577	47	thrombogenic	thrombogenic	JJ
cord-015910-d9gxew91	577	48	cardiovascular	cardiovascular	JJ
cord-015910-d9gxew91	577	49	disease	disease	NN
cord-015910-d9gxew91	577	50	risk	risk	NN
cord-015910-d9gxew91	577	51	factors	factor	NNS
cord-015910-d9gxew91	577	52	among	among	IN
cord-015910-d9gxew91	577	53	men	man	NNS
cord-015910-d9gxew91	578	1	The	the	DT
cord-015910-d9gxew91	578	2	concurrent	concurrent	JJ
cord-015910-d9gxew91	578	3	accumulation	accumulation	NN
cord-015910-d9gxew91	578	4	of	of	IN
cord-015910-d9gxew91	578	5	intra	intra	JJ
cord-015910-d9gxew91	578	6	-	-	JJ
cord-015910-d9gxew91	578	7	abdominal	abdominal	JJ
cord-015910-d9gxew91	578	8	and	and	CC
cord-015910-d9gxew91	578	9	subcutaneous	subcutaneous	JJ
cord-015910-d9gxew91	578	10	fat	fat	NN
cord-015910-d9gxew91	578	11	explains	explain	VBZ
cord-015910-d9gxew91	578	12	the	the	DT
cord-015910-d9gxew91	578	13	association	association	NN
cord-015910-d9gxew91	578	14	between	between	IN
cord-015910-d9gxew91	578	15	insulin	insulin	NN
cord-015910-d9gxew91	578	16	resistance	resistance	NN
cord-015910-d9gxew91	578	17	and	and	CC
cord-015910-d9gxew91	578	18	plasma	plasma	NN
cord-015910-d9gxew91	578	19	leptin	leptin	NN
cord-015910-d9gxew91	578	20	concentrations	concentration	NNS
cord-015910-d9gxew91	578	21	:	:	:
cord-015910-d9gxew91	578	22	Distinct	distinct	JJ
cord-015910-d9gxew91	578	23	metabolic	metabolic	JJ
cord-015910-d9gxew91	578	24	effects	effect	NNS
cord-015910-d9gxew91	578	25	of	of	IN
cord-015910-d9gxew91	578	26	two	two	CD
cord-015910-d9gxew91	578	27	fat	fat	JJ
cord-015910-d9gxew91	578	28	compartments	compartment	NNS
cord-015910-d9gxew91	578	29	Selective	selective	JJ
cord-015910-d9gxew91	578	30	aspects	aspect	NNS
cord-015910-d9gxew91	578	31	of	of	IN
cord-015910-d9gxew91	578	32	the	the	DT
cord-015910-d9gxew91	578	33	insulin	insulin	NN
cord-015910-d9gxew91	578	34	resistance	resistance	NN
cord-015910-d9gxew91	578	35	syndrome	syndrome	NN
cord-015910-d9gxew91	579	1	The	the	DT
cord-015910-d9gxew91	579	2	pleiotropic	pleiotropic	JJ
cord-015910-d9gxew91	579	3	functions	function	NNS
cord-015910-d9gxew91	579	4	of	of	IN
cord-015910-d9gxew91	579	5	peroxisome	peroxisome	NN
cord-015910-d9gxew91	579	6	proliferator	proliferator	NN
cord-015910-d9gxew91	579	7	-	-	HYPH
cord-015910-d9gxew91	579	8	activated	activate	VBN
cord-015910-d9gxew91	579	9	receptor	receptor	NN
cord-015910-d9gxew91	579	10	gamma	gamma	NN
cord-015910-d9gxew91	579	11	Glutamine	glutamine	NN
cord-015910-d9gxew91	579	12	enriched	enrich	VBD
cord-015910-d9gxew91	579	13	TPN	TPN	NNP
cord-015910-d9gxew91	579	14	enhances	enhance	VBZ
cord-015910-d9gxew91	579	15	plasma	plasma	NN
cord-015910-d9gxew91	579	16	glutathione	glutathione	NN
cord-015910-d9gxew91	579	17	in	in	IN
cord-015910-d9gxew91	579	18	resting	rest	VBG
cord-015910-d9gxew91	579	19	state	state	NN
cord-015910-d9gxew91	579	20	N	n	CD
cord-015910-d9gxew91	579	21	-	-	HYPH
cord-015910-d9gxew91	579	22	Acetylcysteine	Acetylcysteine	NNP
cord-015910-d9gxew91	579	23	replenishes	replenish	VBZ
cord-015910-d9gxew91	579	24	glutathione	glutathione	NN
cord-015910-d9gxew91	579	25	in	in	IN
cord-015910-d9gxew91	579	26	HIV	HIV	NNP
cord-015910-d9gxew91	579	27	infection	infection	NN
cord-015910-d9gxew91	579	28	Low	low	JJ
cord-015910-d9gxew91	579	29	-	-	HYPH
cord-015910-d9gxew91	579	30	density	density	NN
cord-015910-d9gxew91	579	31	lipoprotein	lipoprotein	NN
cord-015910-d9gxew91	579	32	postsecretory	postsecretory	NN
cord-015910-d9gxew91	579	33	modification	modification	NN
cord-015910-d9gxew91	579	34	,	,	,
cord-015910-d9gxew91	579	35	monocyte	monocyte	NNP
cord-015910-d9gxew91	579	36	function	function	NN
cord-015910-d9gxew91	579	37	,	,	,
cord-015910-d9gxew91	579	38	and	and	CC
cord-015910-d9gxew91	579	39	circulating	circulate	VBG
cord-015910-d9gxew91	579	40	adhesion	adhesion	NN
cord-015910-d9gxew91	579	41	molecules	molecule	NNS
cord-015910-d9gxew91	579	42	in	in	IN
cord-015910-d9gxew91	579	43	type	type	NN
cord-015910-d9gxew91	579	44	2	2	CD
cord-015910-d9gxew91	579	45	diabetic	diabetic	JJ
cord-015910-d9gxew91	579	46	patients	patient	NNS
cord-015910-d9gxew91	579	47	with	with	IN
cord-015910-d9gxew91	579	48	and	and	CC
cord-015910-d9gxew91	579	49	without	without	IN
cord-015910-d9gxew91	579	50	macrovascular	macrovascular	JJ
cord-015910-d9gxew91	579	51	complications	complication	NNS
cord-015910-d9gxew91	579	52	:	:	:
cord-015910-d9gxew91	580	1	The	the	DT
cord-015910-d9gxew91	580	2	effect	effect	NN
cord-015910-d9gxew91	580	3	of	of	IN
cord-015910-d9gxew91	580	4	alpha	alpha	NN
cord-015910-d9gxew91	580	5	-	-	HYPH
cord-015910-d9gxew91	580	6	tocopherol	tocopherol	NN
cord-015910-d9gxew91	580	7	supplementation	supplementation	NN
cord-015910-d9gxew91	580	8	Guns	gun	NNS
cord-015910-d9gxew91	580	9	,	,	,
cord-015910-d9gxew91	580	10	germs	germ	NNS
cord-015910-d9gxew91	580	11	and	and	CC
cord-015910-d9gxew91	580	12	steel	steel	NN
cord-015910-d9gxew91	580	13	:	:	:
cord-015910-d9gxew91	580	14	The	the	DT
cord-015910-d9gxew91	580	15	fate	fate	NN
cord-015910-d9gxew91	580	16	of	of	IN
cord-015910-d9gxew91	580	17	human	human	JJ
cord-015910-d9gxew91	580	18	societies	society	NNS
cord-015910-d9gxew91	580	19	~-Tocopherol	~-tocopherol	ADD
cord-015910-d9gxew91	581	1	supplementation	supplementation	NN
cord-015910-d9gxew91	581	2	reduces	reduce	VBZ
cord-015910-d9gxew91	581	3	systemic	systemic	JJ
cord-015910-d9gxew91	581	4	markers	marker	NNS
cord-015910-d9gxew91	581	5	of	of	IN
cord-015910-d9gxew91	581	6	oxidative	oxidative	JJ
cord-015910-d9gxew91	581	7	damage	damage	NN
cord-015910-d9gxew91	581	8	in	in	IN
cord-015910-d9gxew91	581	9	healthy	healthy	JJ
cord-015910-d9gxew91	581	10	adults	adult	NNS
cord-015910-d9gxew91	582	1	The	the	DT
cord-015910-d9gxew91	582	2	influence	influence	NN
cord-015910-d9gxew91	582	3	of	of	IN
cord-015910-d9gxew91	582	4	lipoxygenase	lipoxygenase	NN
cord-015910-d9gxew91	582	5	inhibitors	inhibitor	NNS
cord-015910-d9gxew91	582	6	on	on	IN
cord-015910-d9gxew91	582	7	the	the	DT
cord-015910-d9gxew91	582	8	in	in	FW
cord-015910-d9gxew91	582	9	vitro	vitro	FW
cord-015910-d9gxew91	582	10	production	production	NN
cord-015910-d9gxew91	582	11	of	of	IN
cord-015910-d9gxew91	582	12	human	human	JJ
cord-015910-d9gxew91	582	13	leukocytic	leukocytic	JJ
cord-015910-d9gxew91	582	14	pyrogen	pyrogen	NNP
cord-015910-d9gxew91	582	15	and	and	CC
cord-015910-d9gxew91	582	16	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	582	17	activating	activate	VBG
cord-015910-d9gxew91	582	18	factor	factor	NN
cord-015910-d9gxew91	582	19	(	(	-LRB-
cord-015910-d9gxew91	582	20	interleukin-1	interleukin-1	NN
cord-015910-d9gxew91	582	21	)	)	-RRB-
cord-015910-d9gxew91	582	22	Functions	function	NNS
cord-015910-d9gxew91	582	23	of	of	IN
cord-015910-d9gxew91	582	24	glutathione	glutathione	NN
cord-015910-d9gxew91	582	25	and	and	CC
cord-015910-d9gxew91	582	26	glutathione	glutathione	NN
cord-015910-d9gxew91	582	27	disulphide	disulphide	NN
cord-015910-d9gxew91	582	28	in	in	IN
cord-015910-d9gxew91	582	29	immunology	immunology	NN
cord-015910-d9gxew91	582	30	and	and	CC
cord-015910-d9gxew91	582	31	immunopathology	immunopathology	VBG
cord-015910-d9gxew91	582	32	Chronic	Chronic	NNP
cord-015910-d9gxew91	582	33	activation	activation	NN
cord-015910-d9gxew91	582	34	of	of	IN
cord-015910-d9gxew91	582	35	the	the	DT
cord-015910-d9gxew91	582	36	innate	innate	JJ
cord-015910-d9gxew91	582	37	immune	immune	JJ
cord-015910-d9gxew91	582	38	system	system	NN
cord-015910-d9gxew91	582	39	may	may	MD
cord-015910-d9gxew91	582	40	underlie	underlie	VB
cord-015910-d9gxew91	582	41	the	the	DT
cord-015910-d9gxew91	582	42	metabolic	metabolic	JJ
cord-015910-d9gxew91	582	43	syndrome	syndrome	NN
cord-015910-d9gxew91	582	44	Glutamine	glutamine	NN
cord-015910-d9gxew91	582	45	in	in	IN
cord-015910-d9gxew91	582	46	parenteral	parenteral	JJ
cord-015910-d9gxew91	582	47	nutrition	nutrition	NN
cord-015910-d9gxew91	582	48	SOCS-3	SOCS-3	NNP
cord-015910-d9gxew91	582	49	inhibits	inhibit	VBZ
cord-015910-d9gxew91	582	50	insulin	insulin	NN
cord-015910-d9gxew91	582	51	signaling	signaling	NN
cord-015910-d9gxew91	582	52	and	and	CC
cord-015910-d9gxew91	582	53	is	be	VBZ
cord-015910-d9gxew91	582	54	up	up	RB
cord-015910-d9gxew91	582	55	-	-	HYPH
cord-015910-d9gxew91	582	56	regulated	regulate	VBN
cord-015910-d9gxew91	582	57	in	in	IN
cord-015910-d9gxew91	582	58	response	response	NN
cord-015910-d9gxew91	582	59	to	to	IN
cord-015910-d9gxew91	582	60	tumor	tumor	NN
cord-015910-d9gxew91	582	61	necrosis	necrosis	NN
cord-015910-d9gxew91	582	62	factor	factor	NN
cord-015910-d9gxew91	582	63	-	-	HYPH
cord-015910-d9gxew91	582	64	alpha	alpha	NN
cord-015910-d9gxew91	582	65	in	in	IN
cord-015910-d9gxew91	582	66	the	the	DT
cord-015910-d9gxew91	582	67	adipose	adipose	JJ
cord-015910-d9gxew91	582	68	tissue	tissue	NN
cord-015910-d9gxew91	582	69	of	of	IN
cord-015910-d9gxew91	582	70	obese	obese	JJ
cord-015910-d9gxew91	582	71	mice	mouse	NNS
cord-015910-d9gxew91	583	1	The	the	DT
cord-015910-d9gxew91	583	2	effect	effect	NN
cord-015910-d9gxew91	583	3	of	of	IN
cord-015910-d9gxew91	583	4	dietary	dietary	JJ
cord-015910-d9gxew91	583	5	supplementation	supplementation	NN
cord-015910-d9gxew91	583	6	with	with	IN
cord-015910-d9gxew91	583	7	n-3	n-3	JJ
cord-015910-d9gxew91	583	8	polyunsaturated	polyunsaturated	JJ
cord-015910-d9gxew91	583	9	fatty	fatty	JJ
cord-015910-d9gxew91	583	10	acids	acid	NNS
cord-015910-d9gxew91	583	11	on	on	IN
cord-015910-d9gxew91	583	12	the	the	DT
cord-015910-d9gxew91	583	13	synthesis	synthesis	NN
cord-015910-d9gxew91	584	1	ofinterleukin-1	ofinterleukin-1	NNP
cord-015910-d9gxew91	584	2	and	and	CC
cord-015910-d9gxew91	584	3	tumor	tumor	NN
cord-015910-d9gxew91	584	4	necrosis	necrosis	NN
cord-015910-d9gxew91	584	5	factor	factor	NN
cord-015910-d9gxew91	584	6	by	by	IN
cord-015910-d9gxew91	584	7	mononuclear	mononuclear	JJ
cord-015910-d9gxew91	584	8	cells	cell	NNS
cord-015910-d9gxew91	584	9	Age	age	NN
cord-015910-d9gxew91	584	10	-	-	HYPH
cord-015910-d9gxew91	584	11	associated	associate	VBN
cord-015910-d9gxew91	584	12	increased	increase	VBN
cord-015910-d9gxew91	584	13	interleukin-6	interleukin-6	NNP
cord-015910-d9gxew91	584	14	gene	gene	NN
cord-015910-d9gxew91	584	15	expression	expression	NN
cord-015910-d9gxew91	584	16	,	,	,
cord-015910-d9gxew91	584	17	late	late	JJ
cord-015910-d9gxew91	584	18	diseases	disease	NNS
cord-015910-d9gxew91	584	19	,	,	,
cord-015910-d9gxew91	584	20	and	and	CC
cord-015910-d9gxew91	584	21	frailty	frailty	NN
cord-015910-d9gxew91	584	22	Inhibition	inhibition	NN
cord-015910-d9gxew91	584	23	of	of	IN
cord-015910-d9gxew91	584	24	cytokine	cytokine	NN
cord-015910-d9gxew91	584	25	production	production	NN
cord-015910-d9gxew91	584	26	by	by	IN
cord-015910-d9gxew91	584	27	cyclosporin	cyclosporin	NN
cord-015910-d9gxew91	584	28	A	a	NN
cord-015910-d9gxew91	584	29	and	and	CC
cord-015910-d9gxew91	584	30	transforming	transform	VBG
cord-015910-d9gxew91	584	31	growth	growth	NN
cord-015910-d9gxew91	584	32	factor	factor	NN
cord-015910-d9gxew91	585	1	beta	beta	NNP
cord-015910-d9gxew91	585	2	Leptin	Leptin	NNP
cord-015910-d9gxew91	585	3	regulation	regulation	NN
cord-015910-d9gxew91	585	4	of	of	IN
cord-015910-d9gxew91	585	5	the	the	DT
cord-015910-d9gxew91	585	6	immune	immune	JJ
cord-015910-d9gxew91	585	7	response	response	NN
cord-015910-d9gxew91	585	8	and	and	CC
cord-015910-d9gxew91	585	9	the	the	DT
cord-015910-d9gxew91	585	10	immunodeficiency	immunodeficiency	NN
cord-015910-d9gxew91	585	11	of	of	IN
cord-015910-d9gxew91	585	12	malnutrition	malnutrition	NN
cord-015910-d9gxew91	585	13	Serum	Serum	NNP
cord-015910-d9gxew91	585	14	IL-6	IL-6	NNP
cord-015910-d9gxew91	585	15	level	level	NN
cord-015910-d9gxew91	585	16	and	and	CC
cord-015910-d9gxew91	585	17	the	the	DT
cord-015910-d9gxew91	585	18	development	development	NN
cord-015910-d9gxew91	585	19	of	of	IN
cord-015910-d9gxew91	585	20	disability	disability	NN
cord-015910-d9gxew91	585	21	in	in	IN
cord-015910-d9gxew91	585	22	older	old	JJR
cord-015910-d9gxew91	585	23	persons	person	NNS
cord-015910-d9gxew91	586	1	The	the	DT
cord-015910-d9gxew91	586	2	relation	relation	NN
cord-015910-d9gxew91	586	3	of	of	IN
cord-015910-d9gxew91	586	4	body	body	NN
cord-015910-d9gxew91	586	5	fat	fat	NN
cord-015910-d9gxew91	586	6	mass	mass	NN
cord-015910-d9gxew91	586	7	and	and	CC
cord-015910-d9gxew91	586	8	distribution	distribution	NN
cord-015910-d9gxew91	586	9	to	to	IN
cord-015910-d9gxew91	586	10	markers	marker	NNS
cord-015910-d9gxew91	586	11	of	of	IN
cord-015910-d9gxew91	586	12	chronic	chronic	JJ
cord-015910-d9gxew91	586	13	inflammation	inflammation	NN
cord-015910-d9gxew91	587	1	The	the	DT
cord-015910-d9gxew91	587	2	Investigators	investigator	NNS
cord-015910-d9gxew91	587	3	of	of	IN
cord-015910-d9gxew91	587	4	the	the	DT
cord-015910-d9gxew91	587	5	NHBLI	NHBLI	NNP
cord-015910-d9gxew91	587	6	Family	Family	NNP
cord-015910-d9gxew91	587	7	Heart	Heart	NNP
cord-015910-d9gxew91	587	8	Study	Study	NNP
cord-015910-d9gxew91	587	9	.	.	.
cord-015910-d9gxew91	588	1	Association	Association	NNP
cord-015910-d9gxew91	588	2	of	of	IN
cord-015910-d9gxew91	588	3	C	C	NNP
cord-015910-d9gxew91	588	4	-	-	HYPH
cord-015910-d9gxew91	588	5	reactive	reactive	JJ
cord-015910-d9gxew91	588	6	protein	protein	NN
cord-015910-d9gxew91	588	7	with	with	IN
cord-015910-d9gxew91	588	8	markers	marker	NNS
cord-015910-d9gxew91	588	9	of	of	IN
cord-015910-d9gxew91	588	10	prevalent	prevalent	JJ
cord-015910-d9gxew91	588	11	atherosclerotic	atherosclerotic	JJ
cord-015910-d9gxew91	588	12	disease	disease	NN
cord-015910-d9gxew91	588	13	Interaction	Interaction	NNP
cord-015910-d9gxew91	588	14	with	with	IN
cord-015910-d9gxew91	588	15	extracellular	extracellular	JJ
cord-015910-d9gxew91	588	16	matrix	matrix	NN
cord-015910-d9gxew91	588	17	proteins	protein	NNS
cord-015910-d9gxew91	588	18	influences	influence	NNS
cord-015910-d9gxew91	588	19	Lsh	Lsh	NNP
cord-015910-d9gxew91	588	20	/	/	SYM
cord-015910-d9gxew91	588	21	Ity	Ity	NNP
cord-015910-d9gxew91	588	22	/	/	SYM
cord-015910-d9gxew91	588	23	Bcg	Bcg	NNP
cord-015910-d9gxew91	588	24	(	(	-LRB-
cord-015910-d9gxew91	588	25	candidate	candidate	NN
cord-015910-d9gxew91	588	26	Nramp	Nramp	NNP
cord-015910-d9gxew91	588	27	)	)	-RRB-
cord-015910-d9gxew91	588	28	gene	gene	NN
cord-015910-d9gxew91	588	29	regulation	regulation	NN
cord-015910-d9gxew91	588	30	of	of	IN
cord-015910-d9gxew91	588	31	macrophage	macrophage	NN
cord-015910-d9gxew91	588	32	priming	priming	NN
cord-015910-d9gxew91	588	33	/	/	SYM
cord-015910-d9gxew91	588	34	activation	activation	NN
cord-015910-d9gxew91	588	35	for	for	IN
cord-015910-d9gxew91	588	36	tumour	tumour	NN
cord-015910-d9gxew91	588	37	necrosis	necrosis	NN
cord-015910-d9gxew91	588	38	factor	factor	NN
cord-015910-d9gxew91	588	39	-	-	HYPH
cord-015910-d9gxew91	588	40	alpha	alpha	NN
cord-015910-d9gxew91	588	41	and	and	CC
cord-015910-d9gxew91	588	42	nitrite	nitrite	NN
cord-015910-d9gxew91	588	43	release	release	NN
cord-015910-d9gxew91	589	1	A	a	DT
cord-015910-d9gxew91	589	2	common	common	JJ
cord-015910-d9gxew91	589	3	functional	functional	JJ
cord-015910-d9gxew91	589	4	C	c	NN
cord-015910-d9gxew91	589	5	-	-	HYPH
cord-015910-d9gxew91	589	6	T	t	NN
cord-015910-d9gxew91	589	7	substitution	substitution	NN
cord-015910-d9gxew91	589	8	polymorphism	polymorphism	NN
cord-015910-d9gxew91	589	9	in	in	IN
cord-015910-d9gxew91	589	10	the	the	DT
cord-015910-d9gxew91	589	11	promoter	promoter	NN
cord-015910-d9gxew91	589	12	region	region	NN
cord-015910-d9gxew91	589	13	of	of	IN
cord-015910-d9gxew91	589	14	the	the	DT
cord-015910-d9gxew91	589	15	human	human	JJ
cord-015910-d9gxew91	589	16	catalase	catalase	NN
cord-015910-d9gxew91	589	17	gene	gene	NN
cord-015910-d9gxew91	589	18	influences	influence	VBZ
cord-015910-d9gxew91	589	19	transcription	transcription	NN
cord-015910-d9gxew91	589	20	factor	factor	NN
cord-015910-d9gxew91	589	21	binding	binding	NN
cord-015910-d9gxew91	589	22	,	,	,
cord-015910-d9gxew91	589	23	reporter	reporter	NN
cord-015910-d9gxew91	589	24	gene	gene	NN
cord-015910-d9gxew91	589	25	transcription	transcription	NN
cord-015910-d9gxew91	589	26	and	and	CC
cord-015910-d9gxew91	589	27	is	be	VBZ
cord-015910-d9gxew91	589	28	correlated	correlate	VBN
cord-015910-d9gxew91	589	29	to	to	IN
cord-015910-d9gxew91	589	30	blood	blood	NN
cord-015910-d9gxew91	589	31	catalase	catalase	NN
cord-015910-d9gxew91	589	32	levels	level	NNS
cord-015910-d9gxew91	589	33	.	.	.
cord-015910-d9gxew91	590	1	Free	free	JJ
cord-015910-d9gxew91	590	2	RadicalBiology	RadicalBiology	NNP
cord-015910-d9gxew91	590	3	andMedicine	andmedicine	NN
cord-015910-d9gxew91	590	4	Do	do	VBP
cord-015910-d9gxew91	590	5	men	man	NNS
cord-015910-d9gxew91	590	6	and	and	CC
cord-015910-d9gxew91	590	7	women	woman	NNS
cord-015910-d9gxew91	590	8	follow	follow	VBP
cord-015910-d9gxew91	590	9	different	different	JJ
cord-015910-d9gxew91	590	10	trajectories	trajectory	NNS
cord-015910-d9gxew91	590	11	to	to	TO
cord-015910-d9gxew91	590	12	reach	reach	VB
cord-015910-d9gxew91	590	13	extreme	extreme	JJ
cord-015910-d9gxew91	590	14	longevity	longevity	NN
cord-015910-d9gxew91	590	15	?	?	.
cord-015910-d9gxew91	591	1	PPARS	ppar	NNS
cord-015910-d9gxew91	591	2	,	,	,
cord-015910-d9gxew91	591	3	metabolic	metabolic	JJ
cord-015910-d9gxew91	591	4	disease	disease	NN
cord-015910-d9gxew91	591	5	and	and	CC
cord-015910-d9gxew91	591	6	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	591	7	Effect	effect	NN
cord-015910-d9gxew91	591	8	of	of	IN
cord-015910-d9gxew91	591	9	enteral	enteral	NN
cord-015910-d9gxew91	591	10	feeding	feed	VBG
cord-015910-d9gxew91	591	11	with	with	IN
cord-015910-d9gxew91	591	12	eicosapentaenoic	eicosapentaenoic	JJ
cord-015910-d9gxew91	591	13	acid	acid	NN
cord-015910-d9gxew91	591	14	,	,	,
cord-015910-d9gxew91	591	15	7	7	CD
cord-015910-d9gxew91	591	16	-	-	SYM
cord-015910-d9gxew91	591	17	1inolenic	1inolenic	CD
cord-015910-d9gxew91	591	18	acid	acid	NN
cord-015910-d9gxew91	591	19	,	,	,
cord-015910-d9gxew91	591	20	and	and	CC
cord-015910-d9gxew91	591	21	antioxidants	antioxidant	NNS
cord-015910-d9gxew91	591	22	in	in	IN
cord-015910-d9gxew91	591	23	patients	patient	NNS
cord-015910-d9gxew91	591	24	with	with	IN
cord-015910-d9gxew91	591	25	acute	acute	JJ
cord-015910-d9gxew91	591	26	respiratory	respiratory	JJ
cord-015910-d9gxew91	591	27	distress	distress	NN
cord-015910-d9gxew91	591	28	syndrome	syndrome	NN
cord-015910-d9gxew91	591	29	Increased	increase	VBN
cord-015910-d9gxew91	591	30	cytokine	cytokine	NN
cord-015910-d9gxew91	591	31	release	release	NN
cord-015910-d9gxew91	591	32	by	by	IN
cord-015910-d9gxew91	591	33	leucocytes	leucocyte	NNS
cord-015910-d9gxew91	591	34	in	in	IN
cord-015910-d9gxew91	591	35	survivors	survivor	NNS
cord-015910-d9gxew91	591	36	of	of	IN
cord-015910-d9gxew91	591	37	stroke	stroke	NN
cord-015910-d9gxew91	591	38	at	at	IN
cord-015910-d9gxew91	591	39	young	young	JJ
cord-015910-d9gxew91	591	40	age	age	NN
cord-015910-d9gxew91	591	41	Serum	serum	NN
cord-015910-d9gxew91	591	42	albumin	albumin	NN
cord-015910-d9gxew91	591	43	and	and	CC
cord-015910-d9gxew91	591	44	mortality	mortality	NN
cord-015910-d9gxew91	591	45	Theory	theory	NN
cord-015910-d9gxew91	591	46	and	and	CC
cord-015910-d9gxew91	591	47	efficacy	efficacy	NN
cord-015910-d9gxew91	591	48	of	of	IN
cord-015910-d9gxew91	591	49	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	591	50	therapy	therapy	NN
cord-015910-d9gxew91	591	51	Effect	effect	NN
cord-015910-d9gxew91	591	52	of	of	IN
cord-015910-d9gxew91	591	53	antioxidative	antioxidative	JJ
cord-015910-d9gxew91	591	54	vitamins	vitamin	NNS
cord-015910-d9gxew91	591	55	on	on	IN
cord-015910-d9gxew91	591	56	immune	immune	JJ
cord-015910-d9gxew91	591	57	function	function	NN
cord-015910-d9gxew91	591	58	with	with	IN
cord-015910-d9gxew91	591	59	clinical	clinical	JJ
cord-015910-d9gxew91	591	60	applications	application	NNS
cord-015910-d9gxew91	591	61	Dietary	dietary	JJ
cord-015910-d9gxew91	591	62	lipids	lipid	NNS
cord-015910-d9gxew91	591	63	and	and	CC
cord-015910-d9gxew91	591	64	the	the	DT
cord-015910-d9gxew91	591	65	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	591	66	response	response	NN
cord-015910-d9gxew91	591	67	Nutritional	nutritional	JJ
cord-015910-d9gxew91	591	68	modulation	modulation	NN
cord-015910-d9gxew91	591	69	of	of	IN
cord-015910-d9gxew91	591	70	immune	immune	JJ
cord-015910-d9gxew91	591	71	function	function	NN
cord-015910-d9gxew91	591	72	Stress	stress	NN
cord-015910-d9gxew91	591	73	proteins	protein	NNS
cord-015910-d9gxew91	591	74	in	in	IN
cord-015910-d9gxew91	591	75	disease	disease	NN
cord-015910-d9gxew91	591	76	Inflammatory	inflammatory	JJ
cord-015910-d9gxew91	591	77	status	status	NN
cord-015910-d9gxew91	591	78	and	and	CC
cord-015910-d9gxew91	591	79	insulin	insulin	NN
cord-015910-d9gxew91	591	80	resistance	resistance	NN
cord-015910-d9gxew91	591	81	.	.	.
cord-015910-d9gxew91	592	1	Current	current	JJ
cord-015910-d9gxew91	592	2	Opinion	opinion	NN
cord-015910-d9gxew91	592	3	in	in	IN
cord-015910-d9gxew91	592	4	ClinicaINutrition	ClinicaINutrition	NNP
cord-015910-d9gxew91	592	5	and	and	CC
cord-015910-d9gxew91	592	6	Metabolic	Metabolic	NNP
cord-015910-d9gxew91	592	7	Care	Care	NNP
cord-015910-d9gxew91	592	8	Inflammatory	inflammatory	JJ
cord-015910-d9gxew91	592	9	response	response	NN
cord-015910-d9gxew91	592	10	in	in	IN
cord-015910-d9gxew91	592	11	the	the	DT
cord-015910-d9gxew91	592	12	elderly	elderly	JJ
cord-015910-d9gxew91	592	13	.	.	.
cord-015910-d9gxew91	593	1	Current	current	JJ
cord-015910-d9gxew91	593	2	Opinion	opinion	NN
cord-015910-d9gxew91	593	3	in	in	IN
cord-015910-d9gxew91	593	4	Clinical	Clinical	NNP
cord-015910-d9gxew91	593	5	Nutrition	Nutrition	NNP
cord-015910-d9gxew91	593	6	and	and	CC
cord-015910-d9gxew91	593	7	Metabolic	Metabolic	NNP
cord-015910-d9gxew91	593	8	Care	Care	NNP
cord-015910-d9gxew91	593	9	Gene	gene	NN
cord-015910-d9gxew91	593	10	:	:	:
cord-015910-d9gxew91	593	11	gene	gene	NN
cord-015910-d9gxew91	593	12	interactions	interaction	NNS
cord-015910-d9gxew91	593	13	influence	influence	VBP
cord-015910-d9gxew91	593	14	the	the	DT
cord-015910-d9gxew91	593	15	outcome	outcome	NN
cord-015910-d9gxew91	593	16	in	in	IN
cord-015910-d9gxew91	593	17	elderly	elderly	JJ
cord-015910-d9gxew91	593	18	patients	patient	NNS
cord-015910-d9gxew91	594	1	The	the	DT
cord-015910-d9gxew91	594	2	ability	ability	NN
cord-015910-d9gxew91	594	3	of	of	IN
cord-015910-d9gxew91	594	4	fish	fish	NN
cord-015910-d9gxew91	594	5	oil	oil	NN
cord-015910-d9gxew91	594	6	to	to	TO
cord-015910-d9gxew91	594	7	suppress	suppress	VB
cord-015910-d9gxew91	594	8	tumor	tumor	NN
cord-015910-d9gxew91	594	9	necrosis	necrosis	NN
cord-015910-d9gxew91	594	10	factor	factor	NN
cord-015910-d9gxew91	594	11	-	-	HYPH
cord-015910-d9gxew91	594	12	alpha	alpha	NN
cord-015910-d9gxew91	594	13	production	production	NN
cord-015910-d9gxew91	594	14	by	by	IN
cord-015910-d9gxew91	594	15	peripheral	peripheral	JJ
cord-015910-d9gxew91	594	16	blood	blood	NN
cord-015910-d9gxew91	594	17	mononuclear	mononuclear	NN
cord-015910-d9gxew91	594	18	cells	cell	NNS
cord-015910-d9gxew91	594	19	in	in	IN
cord-015910-d9gxew91	594	20	healthy	healthy	JJ
cord-015910-d9gxew91	594	21	men	man	NNS
cord-015910-d9gxew91	594	22	is	be	VBZ
cord-015910-d9gxew91	594	23	associated	associate	VBN
cord-015910-d9gxew91	594	24	with	with	IN
cord-015910-d9gxew91	594	25	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	594	26	in	in	IN
cord-015910-d9gxew91	594	27	genes	gene	NNS
cord-015910-d9gxew91	594	28	which	which	WDT
cord-015910-d9gxew91	594	29	influence	influence	VBP
cord-015910-d9gxew91	594	30	TNF	tnf	NN
cord-015910-d9gxew91	594	31	-	-	HYPH
cord-015910-d9gxew91	594	32	alpha	alpha	NN
cord-015910-d9gxew91	594	33	production	production	NN
cord-015910-d9gxew91	594	34	Cytokine	cytokine	NN
cord-015910-d9gxew91	594	35	genotype	genotype	NN
cord-015910-d9gxew91	594	36	and	and	CC
cord-015910-d9gxew91	594	37	gender	gender	NN
cord-015910-d9gxew91	594	38	influence	influence	VB
cord-015910-d9gxew91	594	39	the	the	DT
cord-015910-d9gxew91	594	40	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	594	41	response	response	NN
cord-015910-d9gxew91	594	42	to	to	IN
cord-015910-d9gxew91	594	43	surgery	surgery	NN
cord-015910-d9gxew91	594	44	IL-10	IL-10	NNP
cord-015910-d9gxew91	594	45	gene	gene	NN
cord-015910-d9gxew91	594	46	promoter	promoter	NN
cord-015910-d9gxew91	594	47	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	594	48	in	in	IN
cord-015910-d9gxew91	594	49	rheumatoid	rheumatoid	NN
cord-015910-d9gxew91	594	50	arthritis	arthritis	NN
cord-015910-d9gxew91	594	51	Markers	marker	NNS
cord-015910-d9gxew91	594	52	of	of	IN
cord-015910-d9gxew91	594	53	inflammation	inflammation	NN
cord-015910-d9gxew91	594	54	and	and	CC
cord-015910-d9gxew91	594	55	cellular	cellular	JJ
cord-015910-d9gxew91	594	56	adhesion	adhesion	NN
cord-015910-d9gxew91	594	57	molecules	molecule	NNS
cord-015910-d9gxew91	594	58	in	in	IN
cord-015910-d9gxew91	594	59	relation	relation	NN
cord-015910-d9gxew91	594	60	to	to	IN
cord-015910-d9gxew91	594	61	insulin	insulin	NN
cord-015910-d9gxew91	594	62	resistance	resistance	NN
cord-015910-d9gxew91	594	63	in	in	IN
cord-015910-d9gxew91	594	64	nondiabetic	nondiabetic	JJ
cord-015910-d9gxew91	594	65	elderly	elderly	NNP
cord-015910-d9gxew91	594	66	:	:	:
cord-015910-d9gxew91	595	1	The	the	DT
cord-015910-d9gxew91	595	2	Rotterdam	Rotterdam	NNP
cord-015910-d9gxew91	595	3	study	study	NN
cord-015910-d9gxew91	595	4	Effect	effect	NN
cord-015910-d9gxew91	595	5	of	of	IN
cord-015910-d9gxew91	595	6	long	long	JJ
cord-015910-d9gxew91	595	7	-	-	HYPH
cord-015910-d9gxew91	595	8	term	term	NN
cord-015910-d9gxew91	595	9	dietary	dietary	JJ
cord-015910-d9gxew91	595	10	antioxidant	antioxidant	JJ
cord-015910-d9gxew91	595	11	supplementation	supplementation	NN
cord-015910-d9gxew91	595	12	on	on	IN
cord-015910-d9gxew91	595	13	influenza	influenza	JJ
cord-015910-d9gxew91	595	14	virous	virous	JJ
cord-015910-d9gxew91	595	15	infection	infection	NN
cord-015910-d9gxew91	595	16	Associations	association	NNS
cord-015910-d9gxew91	595	17	between	between	IN
cord-015910-d9gxew91	595	18	elevated	elevated	JJ
cord-015910-d9gxew91	595	19	interleukin-6	interleukin-6	NNP
cord-015910-d9gxew91	595	20	and	and	CC
cord-015910-d9gxew91	595	21	C	C	NNP
cord-015910-d9gxew91	595	22	-	-	HYPH
cord-015910-d9gxew91	595	23	reactive	reactive	JJ
cord-015910-d9gxew91	595	24	protein	protein	NN
cord-015910-d9gxew91	595	25	levels	level	NNS
cord-015910-d9gxew91	595	26	with	with	IN
cord-015910-d9gxew91	595	27	mortality	mortality	NN
cord-015910-d9gxew91	595	28	in	in	IN
cord-015910-d9gxew91	595	29	the	the	DT
cord-015910-d9gxew91	595	30	elderly	elderly	JJ
cord-015910-d9gxew91	595	31	Pentamethyl	Pentamethyl	NNP
cord-015910-d9gxew91	595	32	-	-	HYPH
cord-015910-d9gxew91	595	33	hydroxychromane	hydroxychromane	NNP
cord-015910-d9gxew91	595	34	,	,	,
cord-015910-d9gxew91	595	35	vitamin	vitamin	NN
cord-015910-d9gxew91	595	36	E	e	NN
cord-015910-d9gxew91	595	37	derivative	derivative	NN
cord-015910-d9gxew91	595	38	,	,	,
cord-015910-d9gxew91	595	39	inhibits	inhibit	VBZ
cord-015910-d9gxew91	595	40	induction	induction	NN
cord-015910-d9gxew91	595	41	of	of	IN
cord-015910-d9gxew91	595	42	nitric	nitric	JJ
cord-015910-d9gxew91	595	43	oxide	oxide	NN
cord-015910-d9gxew91	595	44	synthase	synthase	NN
cord-015910-d9gxew91	595	45	by	by	IN
cord-015910-d9gxew91	595	46	bacterial	bacterial	JJ
cord-015910-d9gxew91	595	47	lipopolysaccharide	lipopolysaccharide	NN
cord-015910-d9gxew91	595	48	NFkappaB	NFkappaB	NNP
cord-015910-d9gxew91	595	49	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	595	50	and	and	CC
cord-015910-d9gxew91	595	51	susceptibility	susceptibility	NN
cord-015910-d9gxew91	595	52	to	to	TO
cord-015910-d9gxew91	595	53	type	type	VB
cord-015910-d9gxew91	595	54	1	1	CD
cord-015910-d9gxew91	595	55	diabetes	diabetes	NN
cord-015910-d9gxew91	596	1	Reduced	reduced	JJ
cord-015910-d9gxew91	596	2	tyrosine	tyrosine	NN
cord-015910-d9gxew91	596	3	kinase	kinase	NN
cord-015910-d9gxew91	596	4	activity	activity	NN
cord-015910-d9gxew91	596	5	of	of	IN
cord-015910-d9gxew91	596	6	the	the	DT
cord-015910-d9gxew91	596	7	insulin	insulin	NN
cord-015910-d9gxew91	596	8	receptor	receptor	NN
cord-015910-d9gxew91	596	9	in	in	IN
cord-015910-d9gxew91	596	10	obesity	obesity	NN
cord-015910-d9gxew91	596	11	-	-	HYPH
cord-015910-d9gxew91	596	12	diabetes	diabetes	NN
cord-015910-d9gxew91	596	13	IRS-1-mediated	irs-1-mediate	VBN
cord-015910-d9gxew91	596	14	inhibition	inhibition	NN
cord-015910-d9gxew91	596	15	of	of	IN
cord-015910-d9gxew91	596	16	insulin	insulin	NN
cord-015910-d9gxew91	596	17	receptor	receptor	NN
cord-015910-d9gxew91	596	18	tyrosine	tyrosine	NN
cord-015910-d9gxew91	596	19	kinase	kinase	NN
cord-015910-d9gxew91	596	20	activity	activity	NN
cord-015910-d9gxew91	596	21	in	in	IN
cord-015910-d9gxew91	596	22	TNF	tnf	NN
cord-015910-d9gxew91	596	23	-	-	HYPH
cord-015910-d9gxew91	596	24	alpha	alpha	NN
cord-015910-d9gxew91	596	25	-	-	HYPH
cord-015910-d9gxew91	596	26	and	and	CC
cord-015910-d9gxew91	596	27	obesity	obesity	NN
cord-015910-d9gxew91	596	28	-	-	HYPH
cord-015910-d9gxew91	596	29	induced	induce	VBN
cord-015910-d9gxew91	596	30	insulin	insulin	NN
cord-015910-d9gxew91	596	31	resistance	resistance	NN
cord-015910-d9gxew91	596	32	Tumor	tumor	NN
cord-015910-d9gxew91	596	33	necrosis	necrosis	NN
cord-015910-d9gxew91	596	34	factor	factor	NN
cord-015910-d9gxew91	597	1	a	a	LS
cord-015910-d9gxew91	598	1	:	:	:
cord-015910-d9gxew91	598	2	A	a	DT
cord-015910-d9gxew91	598	3	key	key	JJ
cord-015910-d9gxew91	598	4	component	component	NN
cord-015910-d9gxew91	598	5	of	of	IN
cord-015910-d9gxew91	598	6	the	the	DT
cord-015910-d9gxew91	598	7	obesitydiabetes	obesitydiabetes	NNPS
cord-015910-d9gxew91	598	8	link	link	NN
cord-015910-d9gxew91	598	9	Randomised	randomised	JJ
cord-015910-d9gxew91	598	10	trial	trial	NN
cord-015910-d9gxew91	598	11	of	of	IN
cord-015910-d9gxew91	598	12	glutamine	glutamine	NN
cord-015910-d9gxew91	598	13	-	-	HYPH
cord-015910-d9gxew91	598	14	enriched	enrich	VBN
cord-015910-d9gxew91	598	15	enteral	enteral	JJ
cord-015910-d9gxew91	598	16	nutrition	nutrition	NN
cord-015910-d9gxew91	598	17	on	on	IN
cord-015910-d9gxew91	598	18	infectious	infectious	JJ
cord-015910-d9gxew91	598	19	morbidity	morbidity	NN
cord-015910-d9gxew91	598	20	in	in	IN
cord-015910-d9gxew91	598	21	patients	patient	NNS
cord-015910-d9gxew91	598	22	with	with	IN
cord-015910-d9gxew91	598	23	multiple	multiple	JJ
cord-015910-d9gxew91	598	24	trauma	trauma	NN
cord-015910-d9gxew91	598	25	Inhibition	inhibition	NN
cord-015910-d9gxew91	598	26	of	of	IN
cord-015910-d9gxew91	598	27	the	the	DT
cord-015910-d9gxew91	598	28	expression	expression	NN
cord-015910-d9gxew91	598	29	of	of	IN
cord-015910-d9gxew91	598	30	inducible	inducible	JJ
cord-015910-d9gxew91	598	31	nitric	nitric	NN
cord-015910-d9gxew91	598	32	oxide	oxide	NN
cord-015910-d9gxew91	598	33	synthase	synthase	NN
cord-015910-d9gxew91	598	34	and	and	CC
cord-015910-d9gxew91	598	35	cyclooxygenase-2	cyclooxygenase-2	NNP
cord-015910-d9gxew91	598	36	in	in	IN
cord-015910-d9gxew91	598	37	macrophages	macrophage	NNS
cord-015910-d9gxew91	598	38	in	in	IN
cord-015910-d9gxew91	598	39	macrophages	macrophage	NNS
cord-015910-d9gxew91	598	40	by	by	IN
cord-015910-d9gxew91	598	41	&	&	CC
cord-015910-d9gxew91	598	42	HQ	HQ	NNP
cord-015910-d9gxew91	598	43	derivatives	derivative	NNS
cord-015910-d9gxew91	598	44	:	:	:
cord-015910-d9gxew91	599	1	Involvement	involvement	NN
cord-015910-d9gxew91	599	2	of	of	IN
cord-015910-d9gxew91	599	3	IkappaB	IkappaB	NNP
cord-015910-d9gxew91	599	4	-	-	HYPH
cord-015910-d9gxew91	599	5	alpha	alpha	NN
cord-015910-d9gxew91	599	6	stabilisation	stabilisation	NN
cord-015910-d9gxew91	599	7	Are	be	VBP
cord-015910-d9gxew91	599	8	differences	difference	NNS
cord-015910-d9gxew91	599	9	in	in	IN
cord-015910-d9gxew91	599	10	interleukin	interleukin	NN
cord-015910-d9gxew91	599	11	10	10	CD
cord-015910-d9gxew91	599	12	production	production	NN
cord-015910-d9gxew91	599	13	associated	associate	VBN
cord-015910-d9gxew91	599	14	with	with	IN
cord-015910-d9gxew91	599	15	joint	joint	JJ
cord-015910-d9gxew91	599	16	damage	damage	NN
cord-015910-d9gxew91	599	17	?	?	.
cord-015910-d9gxew91	600	1	Cysteine	cysteine	NN
cord-015910-d9gxew91	600	2	and	and	CC
cord-015910-d9gxew91	600	3	methionine	methionine	NN
cord-015910-d9gxew91	600	4	supplementation	supplementation	NN
cord-015910-d9gxew91	600	5	modulate	modulate	VBP
cord-015910-d9gxew91	600	6	the	the	DT
cord-015910-d9gxew91	600	7	effect	effect	NN
cord-015910-d9gxew91	600	8	of	of	IN
cord-015910-d9gxew91	600	9	tumor	tumor	NN
cord-015910-d9gxew91	600	10	necrosis	necrosis	NN
cord-015910-d9gxew91	600	11	factor	factor	NN
cord-015910-d9gxew91	600	12	c~	c~	XX
cord-015910-d9gxew91	600	13	on	on	IN
cord-015910-d9gxew91	600	14	protein	protein	NN
cord-015910-d9gxew91	600	15	synthesis	synthesis	NN
cord-015910-d9gxew91	600	16	,	,	,
cord-015910-d9gxew91	600	17	glutathione	glutathione	NN
cord-015910-d9gxew91	600	18	and	and	CC
cord-015910-d9gxew91	600	19	zinc	zinc	NN
cord-015910-d9gxew91	600	20	content	content	NN
cord-015910-d9gxew91	600	21	of	of	IN
cord-015910-d9gxew91	600	22	tissues	tissue	NNS
cord-015910-d9gxew91	600	23	in	in	IN
cord-015910-d9gxew91	600	24	rats	rat	NNS
cord-015910-d9gxew91	600	25	fed	feed	VBD
cord-015910-d9gxew91	600	26	a	a	DT
cord-015910-d9gxew91	600	27	lowprotein	lowprotein	NNP
cord-015910-d9gxew91	600	28	diet	diet	NN
cord-015910-d9gxew91	600	29	Identification	identification	NN
cord-015910-d9gxew91	600	30	of	of	IN
cord-015910-d9gxew91	600	31	high	high	JJ
cord-015910-d9gxew91	600	32	and	and	CC
cord-015910-d9gxew91	600	33	low	low	JJ
cord-015910-d9gxew91	600	34	responders	responder	NNS
cord-015910-d9gxew91	600	35	to	to	IN
cord-015910-d9gxew91	600	36	allographs	allographs	VB
cord-015910-d9gxew91	600	37	The	the	DT
cord-015910-d9gxew91	600	38	effect	effect	NN
cord-015910-d9gxew91	600	39	of	of	IN
cord-015910-d9gxew91	600	40	antimicrobial	antimicrobial	JJ
cord-015910-d9gxew91	600	41	periodontal	periodontal	JJ
cord-015910-d9gxew91	600	42	treatment	treatment	NN
cord-015910-d9gxew91	600	43	on	on	IN
cord-015910-d9gxew91	600	44	circulating	circulate	VBG
cord-015910-d9gxew91	600	45	tumor	tumor	NN
cord-015910-d9gxew91	600	46	necrosis	necrosis	NN
cord-015910-d9gxew91	600	47	factor	factor	NN
cord-015910-d9gxew91	600	48	-	-	HYPH
cord-015910-d9gxew91	600	49	alpha	alpha	NN
cord-015910-d9gxew91	600	50	and	and	CC
cord-015910-d9gxew91	600	51	glycated	glycated	JJ
cord-015910-d9gxew91	600	52	hemoglobin	hemoglobin	NN
cord-015910-d9gxew91	600	53	level	level	NN
cord-015910-d9gxew91	600	54	in	in	IN
cord-015910-d9gxew91	600	55	patients	patient	NNS
cord-015910-d9gxew91	600	56	with	with	IN
cord-015910-d9gxew91	600	57	type	type	NN
cord-015910-d9gxew91	600	58	2	2	CD
cord-015910-d9gxew91	600	59	diabetes	diabete	NNS
cord-015910-d9gxew91	600	60	Heritable	heritable	JJ
cord-015910-d9gxew91	600	61	major	major	JJ
cord-015910-d9gxew91	600	62	histocompatibility	histocompatibility	NN
cord-015910-d9gxew91	600	63	complex	complex	JJ
cord-015910-d9gxew91	600	64	class	class	NN
cord-015910-d9gxew91	600	65	II	ii	NN
cord-015910-d9gxew91	600	66	-	-	HYPH
cord-015910-d9gxew91	600	67	associated	associate	VBN
cord-015910-d9gxew91	600	68	differences	difference	NNS
cord-015910-d9gxew91	600	69	in	in	IN
cord-015910-d9gxew91	600	70	production	production	NN
cord-015910-d9gxew91	600	71	of	of	IN
cord-015910-d9gxew91	600	72	tumor	tumor	NN
cord-015910-d9gxew91	600	73	necrosis	necrosis	NN
cord-015910-d9gxew91	600	74	factor	factor	NN
cord-015910-d9gxew91	600	75	-	-	HYPH
cord-015910-d9gxew91	600	76	co	co	NN
cord-015910-d9gxew91	600	77	Relevance	relevance	NN
cord-015910-d9gxew91	600	78	to	to	IN
cord-015910-d9gxew91	600	79	genetic	genetic	JJ
cord-015910-d9gxew91	600	80	predisposition	predisposition	NN
cord-015910-d9gxew91	600	81	to	to	IN
cord-015910-d9gxew91	600	82	systemic	systemic	JJ
cord-015910-d9gxew91	600	83	lupus	lupus	NN
cord-015910-d9gxew91	600	84	erythematosus	erythematosus	NN
cord-015910-d9gxew91	600	85	Immunocompetence	Immunocompetence	NNP
cord-015910-d9gxew91	600	86	and	and	CC
cord-015910-d9gxew91	600	87	oxidant	oxidant	JJ
cord-015910-d9gxew91	600	88	defense	defense	NN
cord-015910-d9gxew91	600	89	during	during	IN
cord-015910-d9gxew91	600	90	ascorbate	ascorbate	NN
cord-015910-d9gxew91	600	91	depletion	depletion	NN
cord-015910-d9gxew91	600	92	of	of	IN
cord-015910-d9gxew91	600	93	healthy	healthy	JJ
cord-015910-d9gxew91	600	94	men	man	NNS
cord-015910-d9gxew91	600	95	Bacterial	bacterial	JJ
cord-015910-d9gxew91	600	96	lipopolysaccharide	lipopolysaccharide	NN
cord-015910-d9gxew91	600	97	and	and	CC
cord-015910-d9gxew91	600	98	tumor	tumor	NN
cord-015910-d9gxew91	600	99	necrosis	necrosis	NN
cord-015910-d9gxew91	600	100	factor	factor	NN
cord-015910-d9gxew91	600	101	alpha	alpha	NN
cord-015910-d9gxew91	600	102	synergistically	synergistically	RB
cord-015910-d9gxew91	600	103	increase	increase	VBP
cord-015910-d9gxew91	600	104	expression	expression	NN
cord-015910-d9gxew91	600	105	of	of	IN
cord-015910-d9gxew91	600	106	human	human	JJ
cord-015910-d9gxew91	600	107	endothelial	endothelial	JJ
cord-015910-d9gxew91	600	108	adhesion	adhesion	NN
cord-015910-d9gxew91	600	109	molecules	molecule	NNS
cord-015910-d9gxew91	600	110	through	through	IN
cord-015910-d9gxew91	600	111	activation	activation	NN
cord-015910-d9gxew91	600	112	of	of	IN
cord-015910-d9gxew91	600	113	NF	NF	NNP
cord-015910-d9gxew91	600	114	-	-	HYPH
cord-015910-d9gxew91	600	115	kappaB	kappaB	NNP
cord-015910-d9gxew91	600	116	and	and	CC
cord-015910-d9gxew91	600	117	p38	p38	CD
cord-015910-d9gxew91	600	118	mitogen	mitogen	NN
cord-015910-d9gxew91	600	119	-	-	HYPH
cord-015910-d9gxew91	600	120	activated	activate	VBN
cord-015910-d9gxew91	600	121	protein	protein	NN
cord-015910-d9gxew91	600	122	kinase	kinase	NN
cord-015910-d9gxew91	600	123	signaling	signal	VBG
cord-015910-d9gxew91	600	124	pathways	pathway	NNS
cord-015910-d9gxew91	600	125	.	.	.
cord-015910-d9gxew91	601	1	Infection	infection	NN
cord-015910-d9gxew91	601	2	and	and	CC
cord-015910-d9gxew91	601	3	Immunology	Immunology	NNP
cord-015910-d9gxew91	602	1	The	the	DT
cord-015910-d9gxew91	602	2	effect	effect	NN
cord-015910-d9gxew91	602	3	of	of	IN
cord-015910-d9gxew91	602	4	alpha	alpha	NN
cord-015910-d9gxew91	602	5	-	-	HYPH
cord-015910-d9gxew91	602	6	tocopherol	tocopherol	NN
cord-015910-d9gxew91	602	7	supplementation	supplementation	NN
cord-015910-d9gxew91	602	8	on	on	IN
cord-015910-d9gxew91	602	9	LDL	LDL	NNP
cord-015910-d9gxew91	602	10	oxidation	oxidation	NN
cord-015910-d9gxew91	602	11	Severe	severe	JJ
cord-015910-d9gxew91	602	12	hypertriglyceridemia	hypertriglyceridemia	NN
cord-015910-d9gxew91	602	13	with	with	IN
cord-015910-d9gxew91	602	14	insulin	insulin	NN
cord-015910-d9gxew91	602	15	resistance	resistance	NN
cord-015910-d9gxew91	602	16	is	be	VBZ
cord-015910-d9gxew91	602	17	associated	associate	VBN
cord-015910-d9gxew91	602	18	with	with	IN
cord-015910-d9gxew91	602	19	systemic	systemic	JJ
cord-015910-d9gxew91	602	20	inflammation	inflammation	NN
cord-015910-d9gxew91	602	21	:	:	:
cord-015910-d9gxew91	602	22	Reversal	reversal	VB
cord-015910-d9gxew91	602	23	with	with	IN
cord-015910-d9gxew91	602	24	bezafibrate	bezafibrate	NN
cord-015910-d9gxew91	602	25	therapy	therapy	NN
cord-015910-d9gxew91	602	26	in	in	IN
cord-015910-d9gxew91	602	27	a	a	DT
cord-015910-d9gxew91	602	28	randomized	randomized	JJ
cord-015910-d9gxew91	602	29	controlled	control	VBN
cord-015910-d9gxew91	602	30	trial	trial	NN
cord-015910-d9gxew91	602	31	Chlamydial	chlamydial	JJ
cord-015910-d9gxew91	602	32	heat	heat	NN
cord-015910-d9gxew91	602	33	shock	shock	NN
cord-015910-d9gxew91	602	34	protein	protein	NN
cord-015910-d9gxew91	602	35	60	60	CD
cord-015910-d9gxew91	602	36	localizes	localize	VBZ
cord-015910-d9gxew91	602	37	in	in	IN
cord-015910-d9gxew91	602	38	human	human	JJ
cord-015910-d9gxew91	602	39	atheroma	atheroma	NN
cord-015910-d9gxew91	602	40	and	and	CC
cord-015910-d9gxew91	602	41	regulates	regulate	VBZ
cord-015910-d9gxew91	602	42	macrophage	macrophage	NN
cord-015910-d9gxew91	602	43	tumor	tumor	NN
cord-015910-d9gxew91	602	44	necrosis	necrosis	NN
cord-015910-d9gxew91	602	45	factor	factor	NN
cord-015910-d9gxew91	602	46	-	-	:
cord-015910-d9gxew91	602	47	a	a	DT
cord-015910-d9gxew91	602	48	andmatrix	andmatrix	NN
cord-015910-d9gxew91	602	49	metalloproteinase	metalloproteinase	NN
cord-015910-d9gxew91	602	50	expression	expression	NN
cord-015910-d9gxew91	602	51	A	a	DT
cord-015910-d9gxew91	602	52	Natural	natural	JJ
cord-015910-d9gxew91	602	53	resistance	resistance	NN
cord-015910-d9gxew91	602	54	to	to	IN
cord-015910-d9gxew91	602	55	intracellular	intracellular	JJ
cord-015910-d9gxew91	602	56	pathogens	pathogen	NNS
cord-015910-d9gxew91	602	57	:	:	:
cord-015910-d9gxew91	603	1	Modulation	modulation	NN
cord-015910-d9gxew91	603	2	of	of	IN
cord-015910-d9gxew91	603	3	macrophage	macrophage	NN
cord-015910-d9gxew91	603	4	signal	signal	NN
cord-015910-d9gxew91	603	5	transduction	transduction	NN
cord-015910-d9gxew91	603	6	related	relate	VBN
cord-015910-d9gxew91	603	7	to	to	IN
cord-015910-d9gxew91	603	8	the	the	DT
cord-015910-d9gxew91	603	9	expression	expression	NN
cord-015910-d9gxew91	603	10	of	of	IN
cord-015910-d9gxew91	603	11	the	the	DT
cord-015910-d9gxew91	603	12	Bcg	Bcg	NNP
cord-015910-d9gxew91	603	13	locus	locus	NN
cord-015910-d9gxew91	603	14	Plasma	Plasma	NNP
cord-015910-d9gxew91	603	15	proinflammatory	proinflammatory	JJ
cord-015910-d9gxew91	603	16	cytokine	cytokine	NN
cord-015910-d9gxew91	603	17	response	response	NN
cord-015910-d9gxew91	603	18	to	to	IN
cord-015910-d9gxew91	603	19	surgical	surgical	JJ
cord-015910-d9gxew91	603	20	stress	stress	NN
cord-015910-d9gxew91	603	21	in	in	IN
cord-015910-d9gxew91	603	22	elderly	elderly	JJ
cord-015910-d9gxew91	603	23	patients	patient	NNS
cord-015910-d9gxew91	603	24	Modulation	modulation	NN
cord-015910-d9gxew91	603	25	of	of	IN
cord-015910-d9gxew91	603	26	macrophage	macrophage	NN
cord-015910-d9gxew91	603	27	-	-	HYPH
cord-015910-d9gxew91	603	28	derived	derive	VBN
cord-015910-d9gxew91	603	29	interleukin-1	interleukin-1	NN
cord-015910-d9gxew91	603	30	and	and	CC
cord-015910-d9gxew91	603	31	tumour	tumour	NN
cord-015910-d9gxew91	603	32	necrosis	necrosis	NN
cord-015910-d9gxew91	603	33	factor	factor	NN
cord-015910-d9gxew91	603	34	by	by	IN
cord-015910-d9gxew91	603	35	prostaglandin	prostaglandin	NN
cord-015910-d9gxew91	603	36	E2	E2	NNP
cord-015910-d9gxew91	603	37	Allele	Allele	NNP
cord-015910-d9gxew91	603	38	frequencies	frequency	NNS
cord-015910-d9gxew91	603	39	of	of	IN
cord-015910-d9gxew91	603	40	+	+	SYM
cord-015910-d9gxew91	603	41	874TgA	874tga	CD
cord-015910-d9gxew91	603	42	single	single	JJ
cord-015910-d9gxew91	603	43	nucleotide	nucleotide	JJ
cord-015910-d9gxew91	603	44	polymorphism	polymorphism	NN
cord-015910-d9gxew91	603	45	at	at	IN
cord-015910-d9gxew91	603	46	the	the	DT
cord-015910-d9gxew91	603	47	first	first	JJ
cord-015910-d9gxew91	603	48	intron	intron	NN
cord-015910-d9gxew91	603	49	of	of	IN
cord-015910-d9gxew91	603	50	interferon	interferon	NN
cord-015910-d9gxew91	603	51	-	-	HYPH
cord-015910-d9gxew91	603	52	gamma	gamma	NN
cord-015910-d9gxew91	603	53	gene	gene	NN
cord-015910-d9gxew91	603	54	in	in	IN
cord-015910-d9gxew91	603	55	a	a	DT
cord-015910-d9gxew91	603	56	group	group	NN
cord-015910-d9gxew91	603	57	of	of	IN
cord-015910-d9gxew91	603	58	Italian	italian	JJ
cord-015910-d9gxew91	603	59	centenarians	centenarian	NNS
cord-015910-d9gxew91	603	60	Ethanol	ethanol	NN
cord-015910-d9gxew91	603	61	consumption	consumption	NN
cord-015910-d9gxew91	603	62	,	,	,
cord-015910-d9gxew91	603	63	amino	amino	NN
cord-015910-d9gxew91	603	64	acid	acid	NN
cord-015910-d9gxew91	603	65	and	and	CC
cord-015910-d9gxew91	603	66	glutathione	glutathione	NN
cord-015910-d9gxew91	603	67	blood	blood	NN
cord-015910-d9gxew91	603	68	levels	level	NNS
cord-015910-d9gxew91	603	69	in	in	IN
cord-015910-d9gxew91	603	70	patients	patient	NNS
cord-015910-d9gxew91	603	71	with	with	IN
cord-015910-d9gxew91	603	72	and	and	CC
cord-015910-d9gxew91	603	73	without	without	IN
cord-015910-d9gxew91	603	74	chronic	chronic	JJ
cord-015910-d9gxew91	603	75	liver	liver	NN
cord-015910-d9gxew91	603	76	disease	disease	NN
cord-015910-d9gxew91	603	77	Skeletal	skeletal	JJ
cord-015910-d9gxew91	603	78	muscle	muscle	NN
cord-015910-d9gxew91	603	79	glutathione	glutathione	NN
cord-015910-d9gxew91	603	80	after	after	IN
cord-015910-d9gxew91	603	81	surgical	surgical	JJ
cord-015910-d9gxew91	603	82	trauma	trauma	NN
cord-015910-d9gxew91	603	83	Genetics	genetic	NNS
cord-015910-d9gxew91	603	84	and	and	CC
cord-015910-d9gxew91	603	85	the	the	DT
cord-015910-d9gxew91	603	86	pathobiology	pathobiology	NN
cord-015910-d9gxew91	603	87	of	of	IN
cord-015910-d9gxew91	603	88	ageing	age	VBG
cord-015910-d9gxew91	603	89	NHANES	NHANES	NNP
cord-015910-d9gxew91	603	90	III	III	NNP
cord-015910-d9gxew91	603	91	health	health	NN
cord-015910-d9gxew91	603	92	data	datum	NNS
cord-015910-d9gxew91	603	93	relevant	relevant	JJ
cord-015910-d9gxew91	603	94	for	for	IN
cord-015910-d9gxew91	603	95	aging	age	VBG
cord-015910-d9gxew91	603	96	nation	nation	NN
cord-015910-d9gxew91	603	97	Variation	variation	NN
cord-015910-d9gxew91	603	98	in	in	IN
cord-015910-d9gxew91	603	99	the	the	DT
cord-015910-d9gxew91	603	100	TNFalpha	TNFalpha	NNP
cord-015910-d9gxew91	603	101	promoter	promoter	NN
cord-015910-d9gxew91	603	102	region	region	NN
cord-015910-d9gxew91	603	103	associated	associate	VBN
cord-015910-d9gxew91	603	104	with	with	IN
cord-015910-d9gxew91	603	105	susceptibility	susceptibility	NN
cord-015910-d9gxew91	603	106	to	to	IN
cord-015910-d9gxew91	603	107	cerebral	cerebral	JJ
cord-015910-d9gxew91	603	108	malaria	malaria	NN
cord-015910-d9gxew91	603	109	Polymorphic	polymorphic	JJ
cord-015910-d9gxew91	603	110	structure	structure	NN
cord-015910-d9gxew91	603	111	of	of	IN
cord-015910-d9gxew91	603	112	the	the	DT
cord-015910-d9gxew91	603	113	tumour	tumour	NN
cord-015910-d9gxew91	603	114	necrosis	necrosis	NN
cord-015910-d9gxew91	603	115	factor	factor	NN
cord-015910-d9gxew91	603	116	(	(	-LRB-
cord-015910-d9gxew91	603	117	TNF	TNF	NNP
cord-015910-d9gxew91	603	118	)	)	-RRB-
cord-015910-d9gxew91	603	119	locus	locus	NN
cord-015910-d9gxew91	603	120	:	:	:
cord-015910-d9gxew91	604	1	An	an	DT
cord-015910-d9gxew91	604	2	Nco	Nco	NNP
cord-015910-d9gxew91	604	3	I	-PRON-	PRP
cord-015910-d9gxew91	604	4	polymorphism	polymorphism	NN
cord-015910-d9gxew91	604	5	in	in	IN
cord-015910-d9gxew91	604	6	the	the	DT
cord-015910-d9gxew91	604	7	first	first	JJ
cord-015910-d9gxew91	604	8	intron	intron	NN
cord-015910-d9gxew91	604	9	of	of	IN
cord-015910-d9gxew91	604	10	the	the	DT
cord-015910-d9gxew91	604	11	human	human	JJ
cord-015910-d9gxew91	604	12	TNF-~3	TNF-~3	NNS
cord-015910-d9gxew91	604	13	gene	gene	NN
cord-015910-d9gxew91	604	14	correlates	correlate	VBZ
cord-015910-d9gxew91	604	15	with	with	IN
cord-015910-d9gxew91	604	16	a	a	DT
cord-015910-d9gxew91	604	17	variant	variant	JJ
cord-015910-d9gxew91	604	18	amino	amino	NN
cord-015910-d9gxew91	604	19	acid	acid	NN
cord-015910-d9gxew91	604	20	in	in	IN
cord-015910-d9gxew91	604	21	position	position	NN
cord-015910-d9gxew91	604	22	26	26	CD
cord-015910-d9gxew91	604	23	and	and	CC
cord-015910-d9gxew91	604	24	a	a	DT
cord-015910-d9gxew91	604	25	reduced	reduced	JJ
cord-015910-d9gxew91	604	26	level	level	NN
cord-015910-d9gxew91	604	27	of	of	IN
cord-015910-d9gxew91	604	28	TNFc~	tnfc~	CD
cord-015910-d9gxew91	604	29	production	production	NN
cord-015910-d9gxew91	604	30	Vitamin	vitamin	NN
cord-015910-d9gxew91	604	31	E	e	NN
cord-015910-d9gxew91	604	32	supplementation	supplementation	NN
cord-015910-d9gxew91	604	33	enhances	enhance	VBZ
cord-015910-d9gxew91	604	34	cell	cell	NN
cord-015910-d9gxew91	604	35	-	-	HYPH
cord-015910-d9gxew91	604	36	mediated	mediate	VBN
cord-015910-d9gxew91	604	37	immunity	immunity	NN
cord-015910-d9gxew91	604	38	in	in	IN
cord-015910-d9gxew91	604	39	healthy	healthy	JJ
cord-015910-d9gxew91	604	40	elderly	elderly	JJ
cord-015910-d9gxew91	604	41	subjects	subject	NNS
cord-015910-d9gxew91	604	42	Oral	oral	JJ
cord-015910-d9gxew91	604	43	(	(	-LRB-
cord-015910-d9gxew91	604	44	n-3	n-3	NN
cord-015910-d9gxew91	604	45	)	)	-RRB-
cord-015910-d9gxew91	604	46	fatty	fatty	JJ
cord-015910-d9gxew91	604	47	acid	acid	NN
cord-015910-d9gxew91	604	48	supplementation	supplementation	NN
cord-015910-d9gxew91	604	49	supresses	supresse	VBZ
cord-015910-d9gxew91	604	50	cytokine	cytokine	JJ
cord-015910-d9gxew91	604	51	production	production	NN
cord-015910-d9gxew91	604	52	and	and	CC
cord-015910-d9gxew91	604	53	lymphocyte	lymphocyte	NN
cord-015910-d9gxew91	604	54	proliferation	proliferation	NN
cord-015910-d9gxew91	604	55	:	:	:
cord-015910-d9gxew91	605	1	Comparison	comparison	NN
cord-015910-d9gxew91	605	2	between	between	IN
cord-015910-d9gxew91	605	3	young	young	JJ
cord-015910-d9gxew91	605	4	and	and	CC
cord-015910-d9gxew91	605	5	older	old	JJR
cord-015910-d9gxew91	605	6	women	woman	NNS
cord-015910-d9gxew91	605	7	Immunological	immunological	JJ
cord-015910-d9gxew91	605	8	effects	effect	NNS
cord-015910-d9gxew91	605	9	of	of	IN
cord-015910-d9gxew91	605	10	national	national	JJ
cord-015910-d9gxew91	605	11	cholesterol	cholesterol	NN
cord-015910-d9gxew91	605	12	education	education	NN
cord-015910-d9gxew91	605	13	panel	panel	NN
cord-015910-d9gxew91	605	14	(	(	-LRB-
cord-015910-d9gxew91	605	15	NCEP	NCEP	NNP
cord-015910-d9gxew91	605	16	)	)	-RRB-
cord-015910-d9gxew91	606	1	step-2	step-2	NNP
cord-015910-d9gxew91	606	2	diets	diet	NNS
cord-015910-d9gxew91	606	3	with	with	IN
cord-015910-d9gxew91	606	4	and	and	CC
cord-015910-d9gxew91	606	5	without	without	IN
cord-015910-d9gxew91	606	6	fish	fish	NN
cord-015910-d9gxew91	606	7	-	-	HYPH
cord-015910-d9gxew91	606	8	derived	derive	VBN
cord-015910-d9gxew91	606	9	(	(	-LRB-
cord-015910-d9gxew91	606	10	n-3	n-3	NN
cord-015910-d9gxew91	606	11	)	)	-RRB-
cord-015910-d9gxew91	607	1	fatty	fatty	JJ
cord-015910-d9gxew91	607	2	acid	acid	NN
cord-015910-d9gxew91	607	3	enrichment	enrichment	NN
cord-015910-d9gxew91	607	4	Vitamin	vitamin	NN
cord-015910-d9gxew91	607	5	E	e	NN
cord-015910-d9gxew91	607	6	supplementation	supplementation	NN
cord-015910-d9gxew91	607	7	and	and	CC
cord-015910-d9gxew91	607	8	in	in	IN
cord-015910-d9gxew91	607	9	vivo	vivo	NN
cord-015910-d9gxew91	607	10	immune	immune	JJ
cord-015910-d9gxew91	607	11	response	response	NN
cord-015910-d9gxew91	607	12	in	in	IN
cord-015910-d9gxew91	607	13	healthy	healthy	JJ
cord-015910-d9gxew91	607	14	subjects	subject	NNS
cord-015910-d9gxew91	607	15	.	.	.
cord-015910-d9gxew91	608	1	A	a	DT
cord-015910-d9gxew91	608	2	randomized	randomized	JJ
cord-015910-d9gxew91	608	3	controlled	control	VBN
cord-015910-d9gxew91	608	4	trial	trial	NN
cord-015910-d9gxew91	608	5	Vitamin	vitamin	NN
cord-015910-d9gxew91	608	6	E	e	NN
cord-015910-d9gxew91	608	7	supplementation	supplementation	NN
cord-015910-d9gxew91	608	8	suppresses	suppress	VBZ
cord-015910-d9gxew91	608	9	prostaglandin	prostaglandin	NN
cord-015910-d9gxew91	608	10	E2	E2	NNP
cord-015910-d9gxew91	608	11	synthesis	synthesis	NN
cord-015910-d9gxew91	608	12	and	and	CC
cord-015910-d9gxew91	608	13	enhances	enhance	VBZ
cord-015910-d9gxew91	608	14	the	the	DT
cord-015910-d9gxew91	608	15	immune	immune	JJ
cord-015910-d9gxew91	608	16	response	response	NN
cord-015910-d9gxew91	608	17	of	of	IN
cord-015910-d9gxew91	608	18	aged	aged	JJ
cord-015910-d9gxew91	608	19	mice	mouse	NNS
cord-015910-d9gxew91	608	20	Oral	oral	JJ
cord-015910-d9gxew91	608	21	supplementation	supplementation	NN
cord-015910-d9gxew91	608	22	with	with	IN
cord-015910-d9gxew91	608	23	whey	whey	NN
cord-015910-d9gxew91	608	24	proteins	protein	NNS
cord-015910-d9gxew91	609	1	increases	increase	VBZ
cord-015910-d9gxew91	609	2	plasma	plasma	NN
cord-015910-d9gxew91	609	3	glutathione	glutathione	NN
cord-015910-d9gxew91	609	4	levels	level	NNS
cord-015910-d9gxew91	609	5	in	in	IN
cord-015910-d9gxew91	609	6	HIV	HIV	NNP
cord-015910-d9gxew91	609	7	-	-	HYPH
cord-015910-d9gxew91	609	8	infected	infect	VBN
cord-015910-d9gxew91	609	9	patients	patient	NNS
cord-015910-d9gxew91	609	10	Association	Association	NNP
cord-015910-d9gxew91	609	11	of	of	IN
cord-015910-d9gxew91	609	12	TNF2	TNF2	NNP
cord-015910-d9gxew91	609	13	,	,	,
cord-015910-d9gxew91	609	14	a	a	DT
cord-015910-d9gxew91	609	15	TNF	tnf	NN
cord-015910-d9gxew91	609	16	-	-	HYPH
cord-015910-d9gxew91	609	17	alpha	alpha	NN
cord-015910-d9gxew91	609	18	promoter	promoter	NN
cord-015910-d9gxew91	609	19	polymorphism	polymorphism	NN
cord-015910-d9gxew91	609	20	,	,	,
cord-015910-d9gxew91	609	21	with	with	IN
cord-015910-d9gxew91	609	22	septic	septic	JJ
cord-015910-d9gxew91	609	23	shock	shock	NN
cord-015910-d9gxew91	609	24	susceptibility	susceptibility	NN
cord-015910-d9gxew91	609	25	and	and	CC
cord-015910-d9gxew91	609	26	mortality	mortality	NN
cord-015910-d9gxew91	609	27	:	:	:
cord-015910-d9gxew91	610	1	A	a	DT
cord-015910-d9gxew91	610	2	multicenter	multicenter	JJ
cord-015910-d9gxew91	610	3	study	study	NN
cord-015910-d9gxew91	610	4	Association	Association	NNP
cord-015910-d9gxew91	610	5	between	between	IN
cord-015910-d9gxew91	610	6	manganese	manganese	NN
cord-015910-d9gxew91	610	7	superoxide	superoxide	NN
cord-015910-d9gxew91	610	8	dismutase	dismutase	NN
cord-015910-d9gxew91	610	9	(	(	-LRB-
cord-015910-d9gxew91	610	10	MnSOD	MnSOD	NNP
cord-015910-d9gxew91	610	11	)	)	-RRB-
cord-015910-d9gxew91	610	12	gene	gene	NN
cord-015910-d9gxew91	610	13	polymorphism	polymorphism	NN
cord-015910-d9gxew91	610	14	and	and	CC
cord-015910-d9gxew91	610	15	breast	breast	NN
cord-015910-d9gxew91	610	16	cancer	cancer	NN
cord-015910-d9gxew91	610	17	risk	risk	NN
cord-015910-d9gxew91	610	18	Plasma	plasma	NN
cord-015910-d9gxew91	610	19	levels	level	NNS
cord-015910-d9gxew91	610	20	of	of	IN
cord-015910-d9gxew91	610	21	lipid	lipid	NN
cord-015910-d9gxew91	610	22	and	and	CC
cord-015910-d9gxew91	610	23	cholesterol	cholesterol	NN
cord-015910-d9gxew91	610	24	oxidation	oxidation	NN
cord-015910-d9gxew91	610	25	products	product	NNS
cord-015910-d9gxew91	610	26	and	and	CC
cord-015910-d9gxew91	610	27	cytokines	cytokine	NNS
cord-015910-d9gxew91	610	28	in	in	IN
cord-015910-d9gxew91	610	29	diabetes	diabetes	NN
cord-015910-d9gxew91	610	30	mellitus	mellitus	NN
cord-015910-d9gxew91	610	31	and	and	CC
cord-015910-d9gxew91	610	32	smokers	smoker	NNS
cord-015910-d9gxew91	610	33	:	:	:
cord-015910-d9gxew91	610	34	Effect	effect	NN
cord-015910-d9gxew91	610	35	of	of	IN
cord-015910-d9gxew91	610	36	vitamin	vitamin	NN
cord-015910-d9gxew91	610	37	E	e	NN
cord-015910-d9gxew91	610	38	treatment	treatment	NN
cord-015910-d9gxew91	610	39	Potential	potential	JJ
cord-015910-d9gxew91	610	40	role	role	NN
cord-015910-d9gxew91	610	41	of	of	IN
cord-015910-d9gxew91	610	42	TNF	TNF	NNP
cord-015910-d9gxew91	610	43	-	-	HYPH
cord-015910-d9gxew91	610	44	alpha	alpha	NN
cord-015910-d9gxew91	610	45	in	in	IN
cord-015910-d9gxew91	610	46	the	the	DT
cord-015910-d9gxew91	610	47	pathogenesis	pathogenesis	NN
cord-015910-d9gxew91	610	48	of	of	IN
cord-015910-d9gxew91	610	49	insulin	insulin	NN
cord-015910-d9gxew91	610	50	resistance	resistance	NN
cord-015910-d9gxew91	610	51	and	and	CC
cord-015910-d9gxew91	610	52	type	type	NN
cord-015910-d9gxew91	610	53	2	2	CD
cord-015910-d9gxew91	610	54	diabetes	diabete	NNS
cord-015910-d9gxew91	611	1	Inhibition	inhibition	NN
cord-015910-d9gxew91	611	2	of	of	IN
cord-015910-d9gxew91	611	3	monocyte	monocyte	NNP
cord-015910-d9gxew91	611	4	chemoattractant	chemoattractant	NNP
cord-015910-d9gxew91	611	5	protein-1	protein-1	NNP
cord-015910-d9gxew91	611	6	expression	expression	NN
cord-015910-d9gxew91	611	7	in	in	IN
cord-015910-d9gxew91	611	8	cytokine	cytokine	NN
cord-015910-d9gxew91	611	9	-	-	HYPH
cord-015910-d9gxew91	611	10	treated	treat	VBN
cord-015910-d9gxew91	611	11	human	human	JJ
cord-015910-d9gxew91	611	12	lung	lung	NN
cord-015910-d9gxew91	611	13	epithelial	epithelial	NN
cord-015910-d9gxew91	611	14	cells	cell	NNS
cord-015910-d9gxew91	611	15	by	by	IN
cord-015910-d9gxew91	611	16	thiazolidinedione	thiazolidinedione	NNP
cord-015910-d9gxew91	611	17	Total	Total	NNP
cord-015910-d9gxew91	611	18	parenteral	parenteral	JJ
cord-015910-d9gxew91	611	19	nutrition	nutrition	NN
cord-015910-d9gxew91	611	20	with	with	IN
cord-015910-d9gxew91	611	21	glutamine	glutamine	NN
cord-015910-d9gxew91	611	22	dipeptide	dipeptide	NN
cord-015910-d9gxew91	611	23	after	after	IN
cord-015910-d9gxew91	611	24	major	major	JJ
cord-015910-d9gxew91	611	25	surgery	surgery	NN
cord-015910-d9gxew91	611	26	.	.	.
cord-015910-d9gxew91	612	1	A	a	DT
cord-015910-d9gxew91	612	2	double	double	JJ
cord-015910-d9gxew91	612	3	blind	blind	JJ
cord-015910-d9gxew91	612	4	controlled	control	VBN
cord-015910-d9gxew91	612	5	study	study	NN
cord-015910-d9gxew91	612	6	Prevalence	prevalence	NN
cord-015910-d9gxew91	612	7	of	of	IN
cord-015910-d9gxew91	612	8	low	low	JJ
cord-015910-d9gxew91	612	9	body	body	NN
cord-015910-d9gxew91	612	10	mass	mass	NN
cord-015910-d9gxew91	612	11	in	in	IN
cord-015910-d9gxew91	612	12	rheumatoid	rheumatoid	NNP
cord-015910-d9gxew91	612	13	arthritis	arthritis	NN
cord-015910-d9gxew91	612	14	:	:	:
cord-015910-d9gxew91	612	15	Association	Association	NNP
cord-015910-d9gxew91	612	16	with	with	IN
cord-015910-d9gxew91	612	17	the	the	DT
cord-015910-d9gxew91	612	18	acute	acute	JJ
cord-015910-d9gxew91	612	19	phase	phase	NN
cord-015910-d9gxew91	612	20	response	response	NN
cord-015910-d9gxew91	612	21	Increase	increase	NN
cord-015910-d9gxew91	612	22	in	in	IN
cord-015910-d9gxew91	612	23	IL-6	IL-6	NNP
cord-015910-d9gxew91	612	24	and	and	CC
cord-015910-d9gxew91	612	25	decrease	decrease	NN
cord-015910-d9gxew91	612	26	of	of	IN
cord-015910-d9gxew91	612	27	interleukin	interleukin	NN
cord-015910-d9gxew91	612	28	2	2	CD
cord-015910-d9gxew91	612	29	production	production	NN
cord-015910-d9gxew91	612	30	during	during	IN
cord-015910-d9gxew91	612	31	the	the	DT
cord-015910-d9gxew91	612	32	ageing	age	VBG
cord-015910-d9gxew91	612	33	process	process	NN
cord-015910-d9gxew91	612	34	are	be	VBP
cord-015910-d9gxew91	612	35	influenced	influence	VBN
cord-015910-d9gxew91	612	36	by	by	IN
cord-015910-d9gxew91	612	37	health	health	NN
cord-015910-d9gxew91	612	38	status	status	NN
cord-015910-d9gxew91	612	39	Glutamine	glutamine	NN
cord-015910-d9gxew91	612	40	metabolism	metabolism	NN
cord-015910-d9gxew91	612	41	in	in	IN
cord-015910-d9gxew91	612	42	lymphocytes	lymphocyte	NNS
cord-015910-d9gxew91	612	43	.	.	.
cord-015910-d9gxew91	613	1	Its	-PRON-	PRP$
cord-015910-d9gxew91	613	2	biochemistry	biochemistry	NN
cord-015910-d9gxew91	613	3	,	,	,
cord-015910-d9gxew91	613	4	physiology	physiology	NN
cord-015910-d9gxew91	613	5	and	and	CC
cord-015910-d9gxew91	613	6	clinical	clinical	JJ
cord-015910-d9gxew91	613	7	importance	importance	NN
cord-015910-d9gxew91	613	8	Relation	relation	NN
cord-015910-d9gxew91	613	9	between	between	IN
cord-015910-d9gxew91	613	10	plasma	plasma	NN
cord-015910-d9gxew91	613	11	tumor	tumor	NN
cord-015910-d9gxew91	613	12	necrosis	necrosis	NN
cord-015910-d9gxew91	613	13	factor	factor	NN
cord-015910-d9gxew91	613	14	-	-	HYPH
cord-015910-d9gxew91	613	15	alpha	alpha	NN
cord-015910-d9gxew91	613	16	and	and	CC
cord-015910-d9gxew91	613	17	insulin	insulin	NN
cord-015910-d9gxew91	613	18	sensitivity	sensitivity	NN
cord-015910-d9gxew91	613	19	in	in	IN
cord-015910-d9gxew91	613	20	elderly	elderly	JJ
cord-015910-d9gxew91	613	21	men	man	NNS
cord-015910-d9gxew91	613	22	with	with	IN
cord-015910-d9gxew91	613	23	non	non	JJ
cord-015910-d9gxew91	613	24	-	-	JJ
cord-015910-d9gxew91	613	25	insulin	insulin	JJ
cord-015910-d9gxew91	613	26	-	-	HYPH
cord-015910-d9gxew91	613	27	dependent	dependent	JJ
cord-015910-d9gxew91	613	28	diabetes	diabetes	NN
cord-015910-d9gxew91	613	29	mellitus	mellitus	NN
cord-015910-d9gxew91	613	30	Periodontal	periodontal	JJ
cord-015910-d9gxew91	613	31	inflammation	inflammation	NN
cord-015910-d9gxew91	613	32	and	and	CC
cord-015910-d9gxew91	613	33	insulin	insulin	NN
cord-015910-d9gxew91	613	34	resistance	resistance	NN
cord-015910-d9gxew91	613	35	--	--	:
cord-015910-d9gxew91	613	36	lessons	lesson	NNS
cord-015910-d9gxew91	613	37	from	from	IN
cord-015910-d9gxew91	613	38	obesity	obesity	NN
cord-015910-d9gxew91	613	39	Age	age	NN
cord-015910-d9gxew91	613	40	-	-	HYPH
cord-015910-d9gxew91	613	41	dependent	dependent	JJ
cord-015910-d9gxew91	613	42	oxidative	oxidative	JJ
cord-015910-d9gxew91	613	43	stress	stress	NN
cord-015910-d9gxew91	613	44	in	in	IN
cord-015910-d9gxew91	613	45	elderly	elderly	JJ
cord-015910-d9gxew91	613	46	patients	patient	NNS
cord-015910-d9gxew91	613	47	with	with	IN
cord-015910-d9gxew91	613	48	non	non	JJ
cord-015910-d9gxew91	613	49	-	-	JJ
cord-015910-d9gxew91	613	50	insulin	insulin	JJ
cord-015910-d9gxew91	613	51	-	-	HYPH
cord-015910-d9gxew91	613	52	dependent	dependent	JJ
cord-015910-d9gxew91	613	53	diabetes	diabetes	NN
cord-015910-d9gxew91	613	54	mellitus	mellitus	NN
cord-015910-d9gxew91	613	55	C	C	NNP
cord-015910-d9gxew91	613	56	-	-	HYPH
cord-015910-d9gxew91	613	57	reactive	reactive	JJ
cord-015910-d9gxew91	613	58	protein	protein	NN
cord-015910-d9gxew91	613	59	and	and	CC
cord-015910-d9gxew91	613	60	coronary	coronary	JJ
cord-015910-d9gxew91	613	61	heart	heart	NN
cord-015910-d9gxew91	613	62	disease	disease	NN
cord-015910-d9gxew91	613	63	in	in	IN
cord-015910-d9gxew91	613	64	western	western	JJ
cord-015910-d9gxew91	613	65	Turkey	Turkey	NNP
cord-015910-d9gxew91	613	66	Increased	increase	VBN
cord-015910-d9gxew91	613	67	monocyte	monocyte	NNP
cord-015910-d9gxew91	613	68	activation	activation	NN
cord-015910-d9gxew91	613	69	in	in	IN
cord-015910-d9gxew91	613	70	elderly	elderly	JJ
cord-015910-d9gxew91	613	71	patients	patient	NNS
cord-015910-d9gxew91	613	72	after	after	IN
cord-015910-d9gxew91	613	73	surgical	surgical	JJ
cord-015910-d9gxew91	613	74	stress	stress	NN
cord-015910-d9gxew91	613	75	C	c	NN
cord-015910-d9gxew91	613	76	-	-	HYPH
cord-015910-d9gxew91	613	77	reactive	reactive	JJ
cord-015910-d9gxew91	613	78	protein	protein	NN
cord-015910-d9gxew91	613	79	is	be	VBZ
cord-015910-d9gxew91	613	80	independently	independently	RB
cord-015910-d9gxew91	613	81	associated	associate	VBN
cord-015910-d9gxew91	613	82	with	with	IN
cord-015910-d9gxew91	613	83	total	total	JJ
cord-015910-d9gxew91	613	84	body	body	NN
cord-015910-d9gxew91	613	85	fat	fat	NN
cord-015910-d9gxew91	613	86	,	,	,
cord-015910-d9gxew91	613	87	central	central	JJ
cord-015910-d9gxew91	613	88	fat	fat	NN
cord-015910-d9gxew91	613	89	,	,	,
cord-015910-d9gxew91	613	90	and	and	CC
cord-015910-d9gxew91	613	91	insulin	insulin	NN
cord-015910-d9gxew91	613	92	resistance	resistance	NN
cord-015910-d9gxew91	613	93	in	in	IN
cord-015910-d9gxew91	613	94	adult	adult	NN
cord-015910-d9gxew91	613	95	women	woman	NNS
cord-015910-d9gxew91	613	96	Genomic	genomic	JJ
cord-015910-d9gxew91	613	97	interactions	interaction	NNS
cord-015910-d9gxew91	613	98	with	with	IN
cord-015910-d9gxew91	613	99	disease	disease	NN
cord-015910-d9gxew91	613	100	and	and	CC
cord-015910-d9gxew91	613	101	nutrition	nutrition	NN
cord-015910-d9gxew91	613	102	Treatment	treatment	NN
cord-015910-d9gxew91	613	103	with	with	IN
cord-015910-d9gxew91	613	104	glutathione	glutathione	NN
cord-015910-d9gxew91	613	105	precursor	precursor	NN
cord-015910-d9gxew91	613	106	decreases	decrease	VBZ
cord-015910-d9gxew91	613	107	cytokine	cytokine	NN
cord-015910-d9gxew91	613	108	activity	activity	NN
cord-015910-d9gxew91	613	109	Genotyping	Genotyping	NNP
cord-015910-d9gxew91	613	110	for	for	IN
cord-015910-d9gxew91	613	111	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	613	112	in	in	IN
cord-015910-d9gxew91	613	113	interferon	interferon	NN
cord-015910-d9gxew91	613	114	-	-	HYPH
cord-015910-d9gxew91	613	115	gamma	gamma	NN
cord-015910-d9gxew91	613	116	,	,	,
cord-015910-d9gxew91	613	117	interleukin-10	interleukin-10	NN
cord-015910-d9gxew91	613	118	,	,	,
cord-015910-d9gxew91	613	119	transforming	transform	VBG
cord-015910-d9gxew91	613	120	growth	growth	NN
cord-015910-d9gxew91	613	121	factor	factor	NN
cord-015910-d9gxew91	613	122	-	-	HYPH
cord-015910-d9gxew91	613	123	beta	beta	NN
cord-015910-d9gxew91	613	124	1	1	CD
cord-015910-d9gxew91	613	125	and	and	CC
cord-015910-d9gxew91	613	126	tumour	tumour	NN
cord-015910-d9gxew91	613	127	necrosis	necrosis	NN
cord-015910-d9gxew91	613	128	factor	factor	NN
cord-015910-d9gxew91	613	129	-	-	HYPH
cord-015910-d9gxew91	613	130	alpha	alpha	NN
cord-015910-d9gxew91	613	131	genes	gene	NNS
cord-015910-d9gxew91	613	132	:	:	:
cord-015910-d9gxew91	613	133	a	a	DT
cord-015910-d9gxew91	613	134	technical	technical	JJ
cord-015910-d9gxew91	613	135	report	report	NN
cord-015910-d9gxew91	613	136	Changes	change	NNS
cord-015910-d9gxew91	613	137	in	in	IN
cord-015910-d9gxew91	613	138	proinflammatory	proinflammatory	JJ
cord-015910-d9gxew91	613	139	cytokine	cytokine	NN
cord-015910-d9gxew91	613	140	activity	activity	NN
cord-015910-d9gxew91	613	141	after	after	IN
cord-015910-d9gxew91	613	142	menopause	menopause	NN
cord-015910-d9gxew91	613	143	C	C	NNP
cord-015910-d9gxew91	613	144	-	-	HYPH
cord-015910-d9gxew91	613	145	reactive	reactive	JJ
cord-015910-d9gxew91	613	146	protein	protein	NN
cord-015910-d9gxew91	613	147	,	,	,
cord-015910-d9gxew91	613	148	interleukin	interleukin	NN
cord-015910-d9gxew91	613	149	6	6	CD
cord-015910-d9gxew91	613	150	,	,	,
cord-015910-d9gxew91	613	151	and	and	CC
cord-015910-d9gxew91	613	152	risk	risk	NN
cord-015910-d9gxew91	613	153	of	of	IN
cord-015910-d9gxew91	613	154	developing	develop	VBG
cord-015910-d9gxew91	613	155	type	type	NN
cord-015910-d9gxew91	613	156	2	2	CD
cord-015910-d9gxew91	613	157	diabetes	diabetes	NN
cord-015910-d9gxew91	613	158	mellitus	mellitus	NN
cord-015910-d9gxew91	613	159	Asymptomatic	asymptomatic	JJ
cord-015910-d9gxew91	613	160	bacteriuria	bacteriuria	NN
cord-015910-d9gxew91	613	161	in	in	IN
cord-015910-d9gxew91	613	162	elderly	elderly	JJ
cord-015910-d9gxew91	613	163	humans	human	NNS
cord-015910-d9gxew91	613	164	is	be	VBZ
cord-015910-d9gxew91	613	165	associated	associate	VBN
cord-015910-d9gxew91	613	166	with	with	IN
cord-015910-d9gxew91	613	167	increased	increase	VBN
cord-015910-d9gxew91	613	168	levels	level	NNS
cord-015910-d9gxew91	613	169	of	of	IN
cord-015910-d9gxew91	613	170	circulating	circulate	VBG
cord-015910-d9gxew91	613	171	TNF	TNF	NNP
cord-015910-d9gxew91	613	172	receptors	receptor	NNS
cord-015910-d9gxew91	613	173	and	and	CC
cord-015910-d9gxew91	613	174	elevated	elevated	JJ
cord-015910-d9gxew91	613	175	numbers	number	NNS
cord-015910-d9gxew91	613	176	of	of	IN
cord-015910-d9gxew91	613	177	neutrophils	neutrophil	NNS
cord-015910-d9gxew91	613	178	Genetic	genetic	JJ
cord-015910-d9gxew91	613	179	variation	variation	NN
cord-015910-d9gxew91	613	180	in	in	IN
cord-015910-d9gxew91	613	181	cytokine	cytokine	NN
cord-015910-d9gxew91	613	182	production	production	NN
cord-015910-d9gxew91	613	183	may	may	MD
cord-015910-d9gxew91	613	184	be	be	VB
cord-015910-d9gxew91	613	185	protective	protective	JJ
cord-015910-d9gxew91	613	186	of	of	IN
cord-015910-d9gxew91	613	187	ICU	ICU	NNP
cord-015910-d9gxew91	613	188	admission	admission	NN
cord-015910-d9gxew91	613	189	and	and	CC
cord-015910-d9gxew91	613	190	may	may	MD
cord-015910-d9gxew91	613	191	influence	influence	VB
cord-015910-d9gxew91	613	192	mortality	mortality	NN
cord-015910-d9gxew91	614	1	In	in	IN
cord-015910-d9gxew91	614	2	vivo	vivo	NN
cord-015910-d9gxew91	614	3	rates	rate	NNS
cord-015910-d9gxew91	614	4	of	of	IN
cord-015910-d9gxew91	614	5	erythrocyte	erythrocyte	NN
cord-015910-d9gxew91	614	6	glutathione	glutathione	NN
cord-015910-d9gxew91	614	7	synthesis	synthesis	NN
cord-015910-d9gxew91	614	8	in	in	IN
cord-015910-d9gxew91	614	9	children	child	NNS
cord-015910-d9gxew91	614	10	with	with	IN
cord-015910-d9gxew91	614	11	severe	severe	JJ
cord-015910-d9gxew91	614	12	protein	protein	NN
cord-015910-d9gxew91	614	13	-	-	HYPH
cord-015910-d9gxew91	614	14	energy	energy	NN
cord-015910-d9gxew91	614	15	malnutrition	malnutrition	NN
cord-015910-d9gxew91	614	16	Altered	alter	VBN
cord-015910-d9gxew91	614	17	cytokine	cytokine	NN
cord-015910-d9gxew91	614	18	production	production	NN
cord-015910-d9gxew91	614	19	in	in	IN
cord-015910-d9gxew91	614	20	the	the	DT
cord-015910-d9gxew91	614	21	elderly	elderly	JJ
cord-015910-d9gxew91	614	22	Glutathione	glutathione	NN
cord-015910-d9gxew91	614	23	depletion	depletion	NN
cord-015910-d9gxew91	614	24	in	in	IN
cord-015910-d9gxew91	614	25	rats	rat	NNS
cord-015910-d9gxew91	614	26	impairs	impair	VBZ
cord-015910-d9gxew91	614	27	T	t	NN
cord-015910-d9gxew91	614	28	-	-	HYPH
cord-015910-d9gxew91	614	29	cell	cell	NN
cord-015910-d9gxew91	614	30	and	and	CC
cord-015910-d9gxew91	614	31	macrophage	macrophage	NN
cord-015910-d9gxew91	614	32	immune	immune	JJ
cord-015910-d9gxew91	614	33	function	function	NN
cord-015910-d9gxew91	615	1	Age	age	NN
cord-015910-d9gxew91	615	2	and	and	CC
cord-015910-d9gxew91	615	3	sex	sex	NN
cord-015910-d9gxew91	615	4	steroid	steroid	NN
cord-015910-d9gxew91	615	5	-	-	HYPH
cord-015910-d9gxew91	615	6	related	relate	VBN
cord-015910-d9gxew91	615	7	changes	change	NNS
cord-015910-d9gxew91	615	8	in	in	IN
cord-015910-d9gxew91	615	9	glucocorticoid	glucocorticoid	NN
cord-015910-d9gxew91	615	10	sensitivity	sensitivity	NN
cord-015910-d9gxew91	615	11	of	of	IN
cord-015910-d9gxew91	615	12	proinflammatory	proinflammatory	JJ
cord-015910-d9gxew91	615	13	cytokine	cytokine	NN
cord-015910-d9gxew91	615	14	production	production	NN
cord-015910-d9gxew91	615	15	after	after	IN
cord-015910-d9gxew91	615	16	psychosocial	psychosocial	JJ
cord-015910-d9gxew91	615	17	stress	stress	NN
cord-015910-d9gxew91	615	18	Endothelial	endothelial	JJ
cord-015910-d9gxew91	615	19	perturbation	perturbation	NN
cord-015910-d9gxew91	615	20	in	in	IN
cord-015910-d9gxew91	615	21	children	child	NNS
cord-015910-d9gxew91	615	22	and	and	CC
cord-015910-d9gxew91	615	23	adolescents	adolescent	NNS
cord-015910-d9gxew91	615	24	with	with	IN
cord-015910-d9gxew91	615	25	type	type	NN
cord-015910-d9gxew91	615	26	1	1	CD
cord-015910-d9gxew91	615	27	diabetes	diabetes	NN
cord-015910-d9gxew91	615	28	:	:	:
cord-015910-d9gxew91	615	29	Association	Association	NNP
cord-015910-d9gxew91	615	30	with	with	IN
cord-015910-d9gxew91	615	31	markers	marker	NNS
cord-015910-d9gxew91	615	32	of	of	IN
cord-015910-d9gxew91	615	33	the	the	DT
cord-015910-d9gxew91	615	34	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	615	35	reaction	reaction	NN
cord-015910-d9gxew91	615	36	Epidemiologic	Epidemiologic	NNP
cord-015910-d9gxew91	615	37	and	and	CC
cord-015910-d9gxew91	615	38	methodologic	methodologic	JJ
cord-015910-d9gxew91	615	39	problems	problem	NNS
cord-015910-d9gxew91	615	40	in	in	IN
cord-015910-d9gxew91	615	41	determining	determine	VBG
cord-015910-d9gxew91	615	42	nutritional	nutritional	JJ
cord-015910-d9gxew91	615	43	status	status	NN
cord-015910-d9gxew91	615	44	of	of	IN
cord-015910-d9gxew91	615	45	older	old	JJR
cord-015910-d9gxew91	615	46	persons	person	NNS
cord-015910-d9gxew91	616	1	The	the	DT
cord-015910-d9gxew91	616	2	pathogenesis	pathogenesis	NN
cord-015910-d9gxew91	616	3	of	of	IN
cord-015910-d9gxew91	616	4	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	616	5	:	:	:
cord-015910-d9gxew91	617	1	A	a	DT
cord-015910-d9gxew91	617	2	perspective	perspective	NN
cord-015910-d9gxew91	617	3	for	for	IN
cord-015910-d9gxew91	617	4	the	the	DT
cord-015910-d9gxew91	617	5	1990s	1990	NNS
cord-015910-d9gxew91	617	6	Origins	origin	NNS
cord-015910-d9gxew91	617	7	and	and	CC
cord-015910-d9gxew91	617	8	clinical	clinical	JJ
cord-015910-d9gxew91	617	9	relevance	relevance	NN
cord-015910-d9gxew91	617	10	of	of	IN
cord-015910-d9gxew91	617	11	sarcopenia	sarcopenia	NNP
cord-015910-d9gxew91	617	12	Association	Association	NNP
cord-015910-d9gxew91	617	13	of	of	IN
cord-015910-d9gxew91	617	14	tumor	tumor	NN
cord-015910-d9gxew91	617	15	necrosis	necrosis	NN
cord-015910-d9gxew91	617	16	factor	factor	NN
cord-015910-d9gxew91	617	17	alpha	alpha	NN
cord-015910-d9gxew91	617	18	gene	gene	NN
cord-015910-d9gxew91	617	19	promoter	promoter	NN
cord-015910-d9gxew91	617	20	polymorphism	polymorphism	NN
cord-015910-d9gxew91	617	21	with	with	IN
cord-015910-d9gxew91	617	22	the	the	DT
cord-015910-d9gxew91	617	23	presence	presence	NN
cord-015910-d9gxew91	617	24	of	of	IN
cord-015910-d9gxew91	617	25	chronic	chronic	JJ
cord-015910-d9gxew91	617	26	obstructive	obstructive	JJ
cord-015910-d9gxew91	617	27	pulmonary	pulmonary	JJ
cord-015910-d9gxew91	617	28	disease	disease	NN
cord-015910-d9gxew91	617	29	Interactive	interactive	JJ
cord-015910-d9gxew91	617	30	role	role	NN
cord-015910-d9gxew91	617	31	of	of	IN
cord-015910-d9gxew91	617	32	infection	infection	NN
cord-015910-d9gxew91	617	33	,	,	,
cord-015910-d9gxew91	617	34	inflammation	inflammation	NN
cord-015910-d9gxew91	617	35	and	and	CC
cord-015910-d9gxew91	617	36	traditional	traditional	JJ
cord-015910-d9gxew91	617	37	risk	risk	NN
cord-015910-d9gxew91	617	38	factors	factor	NNS
cord-015910-d9gxew91	617	39	in	in	IN
cord-015910-d9gxew91	617	40	atherosclerosis	atherosclerosis	NN
cord-015910-d9gxew91	617	41	and	and	CC
cord-015910-d9gxew91	617	42	coronary	coronary	JJ
cord-015910-d9gxew91	617	43	artery	artery	NN
cord-015910-d9gxew91	617	44	disease	disease	NN
cord-015910-d9gxew91	617	45	Reactive	reactive	JJ
cord-015910-d9gxew91	617	46	oxygen	oxygen	NN
cord-015910-d9gxew91	617	47	intermediates	intermediate	NNS
cord-015910-d9gxew91	617	48	as	as	RB
cord-015910-d9gxew91	617	49	apparently	apparently	RB
cord-015910-d9gxew91	617	50	widely	widely	RB
cord-015910-d9gxew91	617	51	used	use	VBN
cord-015910-d9gxew91	617	52	messengers	messenger	NNS
cord-015910-d9gxew91	617	53	in	in	IN
cord-015910-d9gxew91	617	54	the	the	DT
cord-015910-d9gxew91	617	55	activation	activation	NN
cord-015910-d9gxew91	617	56	of	of	IN
cord-015910-d9gxew91	617	57	nuclear	nuclear	JJ
cord-015910-d9gxew91	617	58	transcription	transcription	NN
cord-015910-d9gxew91	617	59	factor-~J3	factor-~j3	RB
cord-015910-d9gxew91	617	60	and	and	CC
cord-015910-d9gxew91	617	61	HIV-1	HIV-1	NNP
cord-015910-d9gxew91	617	62	Tumor	tumor	NN
cord-015910-d9gxew91	617	63	necrosis	necrosis	NN
cord-015910-d9gxew91	617	64	factor	factor	NN
cord-015910-d9gxew91	617	65	-	-	HYPH
cord-015910-d9gxew91	617	66	alpha	alpha	NN
cord-015910-d9gxew91	617	67	-308	-308	NN
cord-015910-d9gxew91	617	68	promoter	promoter	NN
cord-015910-d9gxew91	617	69	gene	gene	NN
cord-015910-d9gxew91	617	70	polymorphism	polymorphism	NN
cord-015910-d9gxew91	617	71	and	and	CC
cord-015910-d9gxew91	617	72	increased	increase	VBN
cord-015910-d9gxew91	617	73	tumor	tumor	NN
cord-015910-d9gxew91	617	74	necrosis	necrosis	NN
cord-015910-d9gxew91	617	75	factor	factor	NN
cord-015910-d9gxew91	617	76	serum	serum	NN
cord-015910-d9gxew91	617	77	bioactivity	bioactivity	NN
cord-015910-d9gxew91	617	78	in	in	IN
cord-015910-d9gxew91	617	79	farmer	farmer	NN
cord-015910-d9gxew91	617	80	's	's	POS
cord-015910-d9gxew91	617	81	lung	lung	NN
cord-015910-d9gxew91	617	82	patients	patient	NNS
cord-015910-d9gxew91	618	1	Gender	gender	NN
cord-015910-d9gxew91	618	2	differences	difference	NNS
cord-015910-d9gxew91	618	3	in	in	IN
cord-015910-d9gxew91	618	4	sepsis	sepsis	NN
cord-015910-d9gxew91	618	5	:	:	:
cord-015910-d9gxew91	619	1	Genetically	genetically	RB
cord-015910-d9gxew91	619	2	determined	determined	JJ
cord-015910-d9gxew91	619	3	?	?	.
cord-015910-d9gxew91	620	1	Shock	shock	NN
cord-015910-d9gxew91	620	2	Evidence	evidence	NN
cord-015910-d9gxew91	620	3	for	for	IN
cord-015910-d9gxew91	620	4	a	a	DT
cord-015910-d9gxew91	620	5	functional	functional	JJ
cord-015910-d9gxew91	620	6	repeat	repeat	NN
cord-015910-d9gxew91	620	7	polymorphism	polymorphism	NN
cord-015910-d9gxew91	620	8	in	in	IN
cord-015910-d9gxew91	620	9	the	the	DT
cord-015910-d9gxew91	620	10	promoter	promoter	NN
cord-015910-d9gxew91	620	11	of	of	IN
cord-015910-d9gxew91	620	12	the	the	DT
cord-015910-d9gxew91	620	13	human	human	NN
cord-015910-d9gxew91	620	14	NRAMP1	NRAMP1	NNP
cord-015910-d9gxew91	620	15	gene	gene	NN
cord-015910-d9gxew91	620	16	that	that	WDT
cord-015910-d9gxew91	620	17	correlates	correlate	VBZ
cord-015910-d9gxew91	620	18	with	with	IN
cord-015910-d9gxew91	620	19	autoimmune	autoimmune	NN
cord-015910-d9gxew91	620	20	versus	versus	IN
cord-015910-d9gxew91	620	21	infectious	infectious	JJ
cord-015910-d9gxew91	620	22	disease	disease	NN
cord-015910-d9gxew91	620	23	susceptibility	susceptibility	NN
cord-015910-d9gxew91	620	24	Involvement	Involvement	NNP
cord-015910-d9gxew91	620	25	of	of	IN
cord-015910-d9gxew91	620	26	peripheral	peripheral	JJ
cord-015910-d9gxew91	620	27	polymorphonuclear	polymorphonuclear	JJ
cord-015910-d9gxew91	620	28	leukocytes	leukocyte	NNS
cord-015910-d9gxew91	620	29	in	in	IN
cord-015910-d9gxew91	620	30	oxidative	oxidative	JJ
cord-015910-d9gxew91	620	31	stress	stress	NN
cord-015910-d9gxew91	620	32	and	and	CC
cord-015910-d9gxew91	620	33	inflammation	inflammation	NN
cord-015910-d9gxew91	620	34	in	in	IN
cord-015910-d9gxew91	620	35	type	type	NN
cord-015910-d9gxew91	620	36	2	2	CD
cord-015910-d9gxew91	620	37	diabetic	diabetic	JJ
cord-015910-d9gxew91	620	38	patients	patient	NNS
cord-015910-d9gxew91	621	1	Does	do	VBZ
cord-015910-d9gxew91	621	2	N	n	CD
cord-015910-d9gxew91	621	3	-	-	HYPH
cord-015910-d9gxew91	621	4	acetyl	acetyl	NNP
cord-015910-d9gxew91	621	5	cysteine	cysteine	NN
cord-015910-d9gxew91	621	6	inflkuence	inflkuence	NN
cord-015910-d9gxew91	621	7	cytokine	cytokine	NN
cord-015910-d9gxew91	621	8	response	response	NN
cord-015910-d9gxew91	621	9	during	during	IN
cord-015910-d9gxew91	621	10	early	early	JJ
cord-015910-d9gxew91	621	11	human	human	JJ
cord-015910-d9gxew91	621	12	septic	septic	NN
cord-015910-d9gxew91	621	13	shock	shock	NN
cord-015910-d9gxew91	621	14	?	?	.
cord-015910-d9gxew91	622	1	Alterations	alteration	NNS
cord-015910-d9gxew91	622	2	in	in	IN
cord-015910-d9gxew91	622	3	lipid	lipid	NN
cord-015910-d9gxew91	622	4	and	and	CC
cord-015910-d9gxew91	622	5	carbohydrate	carbohydrate	NN
cord-015910-d9gxew91	622	6	metabolism	metabolism	NN
cord-015910-d9gxew91	622	7	in	in	IN
cord-015910-d9gxew91	622	8	sepsis	sepsis	NN
cord-015910-d9gxew91	622	9	Altered	alter	VBN
cord-015910-d9gxew91	622	10	control	control	NN
cord-015910-d9gxew91	622	11	of	of	IN
cord-015910-d9gxew91	622	12	carbohydrate	carbohydrate	NN
cord-015910-d9gxew91	622	13	metabolism	metabolism	NN
cord-015910-d9gxew91	622	14	in	in	IN
cord-015910-d9gxew91	622	15	endotoxemia	endotoxemia	NN
cord-015910-d9gxew91	622	16	Glutathione	glutathione	NN
cord-015910-d9gxew91	622	17	deficiency	deficiency	NN
cord-015910-d9gxew91	622	18	in	in	IN
cord-015910-d9gxew91	622	19	human	human	JJ
cord-015910-d9gxew91	622	20	immunodeficiency	immunodeficiency	NN
cord-015910-d9gxew91	622	21	virus	virus	NN
cord-015910-d9gxew91	622	22	infection	infection	NN
cord-015910-d9gxew91	622	23	Vitamin	vitamin	NN
cord-015910-d9gxew91	622	24	E	e	NN
cord-015910-d9gxew91	622	25	,	,	,
cord-015910-d9gxew91	622	26	a	a	DT
cord-015910-d9gxew91	622	27	modifier	modifier	NN
cord-015910-d9gxew91	622	28	of	of	IN
cord-015910-d9gxew91	622	29	platelet	platelet	NN
cord-015910-d9gxew91	622	30	function	function	NN
cord-015910-d9gxew91	622	31	:	:	:
cord-015910-d9gxew91	622	32	Rationale	rationale	NN
cord-015910-d9gxew91	622	33	and	and	CC
cord-015910-d9gxew91	622	34	use	use	NN
cord-015910-d9gxew91	622	35	in	in	IN
cord-015910-d9gxew91	622	36	cardiovascular	cardiovascular	JJ
cord-015910-d9gxew91	622	37	and	and	CC
cord-015910-d9gxew91	622	38	cerebrovascular	cerebrovascular	JJ
cord-015910-d9gxew91	622	39	disease	disease	NN
cord-015910-d9gxew91	622	40	A	a	DT
cord-015910-d9gxew91	622	41	genomic	genomic	JJ
cord-015910-d9gxew91	622	42	polymorphism	polymorphism	NN
cord-015910-d9gxew91	622	43	within	within	IN
cord-015910-d9gxew91	622	44	the	the	DT
cord-015910-d9gxew91	622	45	tumor	tumor	NN
cord-015910-d9gxew91	622	46	necrosis	necrosis	NN
cord-015910-d9gxew91	622	47	factor	factor	NN
cord-015910-d9gxew91	622	48	locus	locus	NN
cord-015910-d9gxew91	622	49	influences	influence	VBZ
cord-015910-d9gxew91	622	50	plasma	plasma	NN
cord-015910-d9gxew91	622	51	tumor	tumor	NN
cord-015910-d9gxew91	622	52	necrosis	necrosis	NN
cord-015910-d9gxew91	622	53	factor	factor	NN
cord-015910-d9gxew91	622	54	-	-	HYPH
cord-015910-d9gxew91	622	55	alpha	alpha	NN
cord-015910-d9gxew91	622	56	concentrations	concentration	NNS
cord-015910-d9gxew91	622	57	and	and	CC
cord-015910-d9gxew91	622	58	outcome	outcome	NN
cord-015910-d9gxew91	622	59	of	of	IN
cord-015910-d9gxew91	622	60	patients	patient	NNS
cord-015910-d9gxew91	622	61	with	with	IN
cord-015910-d9gxew91	622	62	severe	severe	JJ
cord-015910-d9gxew91	622	63	sepsis	sepsis	NN
cord-015910-d9gxew91	623	1	Interleukin	interleukin	NN
cord-015910-d9gxew91	623	2	10	10	CD
cord-015910-d9gxew91	623	3	(	(	-LRB-
cord-015910-d9gxew91	623	4	IL-10	IL-10	NNP
cord-015910-d9gxew91	623	5	)	)	-RRB-
cord-015910-d9gxew91	623	6	genotypes	genotype	NNS
cord-015910-d9gxew91	623	7	in	in	IN
cord-015910-d9gxew91	623	8	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	623	9	bowel	bowel	NN
cord-015910-d9gxew91	623	10	disease	disease	NN
cord-015910-d9gxew91	623	11	Change	change	NN
cord-015910-d9gxew91	623	12	in	in	IN
cord-015910-d9gxew91	623	13	the	the	DT
cord-015910-d9gxew91	623	14	ratio	ratio	NN
cord-015910-d9gxew91	623	15	of	of	IN
cord-015910-d9gxew91	623	16	interleukin-6	interleukin-6	NNP
cord-015910-d9gxew91	623	17	to	to	TO
cord-015910-d9gxew91	623	18	interleukin-10	interleukin-10	PRP
cord-015910-d9gxew91	623	19	predicts	predict	VBZ
cord-015910-d9gxew91	623	20	a	a	DT
cord-015910-d9gxew91	623	21	poor	poor	JJ
cord-015910-d9gxew91	623	22	outcome	outcome	NN
cord-015910-d9gxew91	623	23	in	in	IN
cord-015910-d9gxew91	623	24	patients	patient	NNS
cord-015910-d9gxew91	623	25	with	with	IN
cord-015910-d9gxew91	623	26	systemic	systemic	JJ
cord-015910-d9gxew91	623	27	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	623	28	response	response	NN
cord-015910-d9gxew91	623	29	syndrome	syndrome	NN
cord-015910-d9gxew91	623	30	Effects	effect	NNS
cord-015910-d9gxew91	623	31	of	of	IN
cord-015910-d9gxew91	623	32	endothelial	endothelial	JJ
cord-015910-d9gxew91	623	33	nitric	nitric	NN
cord-015910-d9gxew91	623	34	oxide	oxide	NN
cord-015910-d9gxew91	623	35	synthase	synthase	NN
cord-015910-d9gxew91	623	36	gene	gene	NN
cord-015910-d9gxew91	623	37	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	623	38	on	on	IN
cord-015910-d9gxew91	623	39	platelet	platelet	NN
cord-015910-d9gxew91	623	40	function	function	NN
cord-015910-d9gxew91	623	41	,	,	,
cord-015910-d9gxew91	623	42	nitric	nitric	NN
cord-015910-d9gxew91	623	43	oxide	oxide	NN
cord-015910-d9gxew91	623	44	release	release	NN
cord-015910-d9gxew91	623	45	,	,	,
cord-015910-d9gxew91	623	46	and	and	CC
cord-015910-d9gxew91	623	47	interactions	interaction	NNS
cord-015910-d9gxew91	623	48	with	with	IN
cord-015910-d9gxew91	623	49	estradiol	estradiol	NNP
cord-015910-d9gxew91	623	50	An	an	DT
cord-015910-d9gxew91	623	51	investigation	investigation	NN
cord-015910-d9gxew91	623	52	ofpolymorphisms	ofpolymorphism	NNS
cord-015910-d9gxew91	623	53	in	in	IN
cord-015910-d9gxew91	623	54	the	the	DT
cord-015910-d9gxew91	623	55	interleukin-10	interleukin-10	NNP
cord-015910-d9gxew91	623	56	gene	gene	NN
cord-015910-d9gxew91	623	57	promoter	promoter	NN
cord-015910-d9gxew91	623	58	Antiinflammatory	antiinflammatory	JJ
cord-015910-d9gxew91	623	59	cytokine	cytokine	NN
cord-015910-d9gxew91	623	60	profile	profile	NN
cord-015910-d9gxew91	623	61	and	and	CC
cord-015910-d9gxew91	623	62	mortality	mortality	NN
cord-015910-d9gxew91	623	63	in	in	IN
cord-015910-d9gxew91	623	64	febrile	febrile	JJ
cord-015910-d9gxew91	623	65	patients	patient	NNS
cord-015910-d9gxew91	623	66	Alphatocopherol	Alphatocopherol	NNP
cord-015910-d9gxew91	623	67	supplementation	supplementation	NN
cord-015910-d9gxew91	623	68	decreases	decrease	VBZ
cord-015910-d9gxew91	623	69	production	production	NN
cord-015910-d9gxew91	623	70	of	of	IN
cord-015910-d9gxew91	623	71	superoxide	superoxide	NN
cord-015910-d9gxew91	623	72	and	and	CC
cord-015910-d9gxew91	623	73	cytokines	cytokine	NNS
cord-015910-d9gxew91	623	74	by	by	IN
cord-015910-d9gxew91	623	75	leukocytes	leukocyte	NNS
cord-015910-d9gxew91	623	76	ex	ex	NN
cord-015910-d9gxew91	623	77	vivo	vivo	NN
cord-015910-d9gxew91	623	78	in	in	IN
cord-015910-d9gxew91	623	79	both	both	CC
cord-015910-d9gxew91	623	80	normolipidemic	normolipidemic	NNP
cord-015910-d9gxew91	623	81	and	and	CC
cord-015910-d9gxew91	623	82	hypertriglyceridemic	hypertriglyceridemic	NNP
cord-015910-d9gxew91	623	83	individuals	individual	NNS
cord-015910-d9gxew91	623	84	Relationship	Relationship	NNP
cord-015910-d9gxew91	623	85	of	of	IN
cord-015910-d9gxew91	623	86	interleukin-6	interleukin-6	NNP
cord-015910-d9gxew91	623	87	and	and	CC
cord-015910-d9gxew91	623	88	tumor	tumor	NN
cord-015910-d9gxew91	623	89	necrosis	necrosis	NN
cord-015910-d9gxew91	623	90	factor	factor	NN
cord-015910-d9gxew91	623	91	-	-	HYPH
cord-015910-d9gxew91	623	92	alpha	alpha	NN
cord-015910-d9gxew91	623	93	with	with	IN
cord-015910-d9gxew91	623	94	muscle	muscle	NN
cord-015910-d9gxew91	623	95	mass	mass	NN
cord-015910-d9gxew91	623	96	and	and	CC
cord-015910-d9gxew91	623	97	muscle	muscle	NN
cord-015910-d9gxew91	623	98	strength	strength	NN
cord-015910-d9gxew91	623	99	in	in	IN
cord-015910-d9gxew91	623	100	elderly	elderly	JJ
cord-015910-d9gxew91	623	101	men	man	NNS
cord-015910-d9gxew91	623	102	and	and	CC
cord-015910-d9gxew91	623	103	women	woman	NNS
cord-015910-d9gxew91	623	104	:	:	:
cord-015910-d9gxew91	624	1	The	the	DT
cord-015910-d9gxew91	624	2	Health	Health	NNP
cord-015910-d9gxew91	624	3	ABC	ABC	NNP
cord-015910-d9gxew91	624	4	Study	Study	NNP
cord-015910-d9gxew91	624	5	Circulating	circulating	NN
cord-015910-d9gxew91	624	6	interleukin-6	interleukin-6	NNP
cord-015910-d9gxew91	624	7	in	in	IN
cord-015910-d9gxew91	624	8	relation	relation	NN
cord-015910-d9gxew91	624	9	to	to	IN
cord-015910-d9gxew91	624	10	adiposity	adiposity	NN
cord-015910-d9gxew91	624	11	,	,	,
cord-015910-d9gxew91	624	12	insulin	insulin	NN
cord-015910-d9gxew91	624	13	action	action	NN
cord-015910-d9gxew91	624	14	,	,	,
cord-015910-d9gxew91	624	15	and	and	CC
cord-015910-d9gxew91	624	16	insulin	insulin	NN
cord-015910-d9gxew91	624	17	secretion	secretion	NN
cord-015910-d9gxew91	625	1	High	high	JJ
cord-015910-d9gxew91	625	2	white	white	JJ
cord-015910-d9gxew91	625	3	blood	blood	NN
cord-015910-d9gxew91	625	4	cell	cell	NN
cord-015910-d9gxew91	625	5	count	count	NN
cord-015910-d9gxew91	625	6	is	be	VBZ
cord-015910-d9gxew91	625	7	associated	associate	VBN
cord-015910-d9gxew91	625	8	with	with	IN
cord-015910-d9gxew91	625	9	a	a	DT
cord-015910-d9gxew91	625	10	worsening	worsen	VBG
cord-015910-d9gxew91	625	11	of	of	IN
cord-015910-d9gxew91	625	12	insulin	insulin	NN
cord-015910-d9gxew91	625	13	sensitivity	sensitivity	NN
cord-015910-d9gxew91	625	14	and	and	CC
cord-015910-d9gxew91	625	15	predicts	predict	VBZ
cord-015910-d9gxew91	625	16	the	the	DT
cord-015910-d9gxew91	625	17	development	development	NN
cord-015910-d9gxew91	625	18	of	of	IN
cord-015910-d9gxew91	625	19	type	type	NN
cord-015910-d9gxew91	625	20	2	2	CD
cord-015910-d9gxew91	625	21	diabetes	diabete	VBZ
cord-015910-d9gxew91	625	22	PPAR	PPAR	NNP
cord-015910-d9gxew91	625	23	-	-	HYPH
cord-015910-d9gxew91	625	24	gamma	gamma	NN
cord-015910-d9gxew91	625	25	and	and	CC
cord-015910-d9gxew91	625	26	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	625	27	bowel	bowel	NN
cord-015910-d9gxew91	625	28	disease	disease	NN
cord-015910-d9gxew91	625	29	:	:	:
cord-015910-d9gxew91	625	30	a	a	DT
cord-015910-d9gxew91	625	31	new	new	JJ
cord-015910-d9gxew91	625	32	therapeutic	therapeutic	JJ
cord-015910-d9gxew91	625	33	target	target	NN
cord-015910-d9gxew91	625	34	for	for	IN
cord-015910-d9gxew91	625	35	ulcerative	ulcerative	JJ
cord-015910-d9gxew91	625	36	colitis	colitis	NN
cord-015910-d9gxew91	625	37	and	and	CC
cord-015910-d9gxew91	625	38	Crohn	Crohn	NNP
cord-015910-d9gxew91	625	39	's	's	POS
cord-015910-d9gxew91	625	40	disease	disease	NN
cord-015910-d9gxew91	625	41	Lack	Lack	NNP
cord-015910-d9gxew91	625	42	of	of	IN
cord-015910-d9gxew91	625	43	association	association	NN
cord-015910-d9gxew91	625	44	between	between	IN
cord-015910-d9gxew91	625	45	human	human	JJ
cord-015910-d9gxew91	625	46	longevity	longevity	NN
cord-015910-d9gxew91	625	47	and	and	CC
cord-015910-d9gxew91	625	48	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	625	49	of	of	IN
cord-015910-d9gxew91	625	50	IL-1	IL-1	NNP
cord-015910-d9gxew91	625	51	cluster	cluster	NN
cord-015910-d9gxew91	625	52	,	,	,
cord-015910-d9gxew91	625	53	IL-6	IL-6	NNP
cord-015910-d9gxew91	625	54	,	,	,
cord-015910-d9gxew91	625	55	IL-10	IL-10	NNP
cord-015910-d9gxew91	625	56	and	and	CC
cord-015910-d9gxew91	625	57	TNF	TNF	NNP
cord-015910-d9gxew91	625	58	-	-	HYPH
cord-015910-d9gxew91	625	59	alpha	alpha	NN
cord-015910-d9gxew91	625	60	genes	gene	NNS
cord-015910-d9gxew91	625	61	in	in	IN
cord-015910-d9gxew91	625	62	Finnish	finnish	JJ
cord-015910-d9gxew91	625	63	nonagenarians	nonagenarian	NNS
cord-015910-d9gxew91	625	64	Genetic	genetic	JJ
cord-015910-d9gxew91	625	65	polymorphisms	polymorphism	NNS
cord-015910-d9gxew91	625	66	in	in	IN
cord-015910-d9gxew91	625	67	the	the	DT
cord-015910-d9gxew91	625	68	tumor	tumor	NN
cord-015910-d9gxew91	625	69	necrosis	necrosis	NN
cord-015910-d9gxew91	625	70	factor	factor	NN
cord-015910-d9gxew91	625	71	locus	locus	NN
cord-015910-d9gxew91	625	72	influence	influence	VBP
cord-015910-d9gxew91	625	73	non	non	NNP
cord-015910-d9gxew91	625	74	-	-	NNP
cord-015910-d9gxew91	625	75	Hodgkin	Hodgkin	NNP
cord-015910-d9gxew91	625	76	's	's	POS
cord-015910-d9gxew91	625	77	lymphoma	lymphoma	NN
cord-015910-d9gxew91	625	78	outcome	outcome	NN
cord-015910-d9gxew91	625	79	Activation	activation	NN
cord-015910-d9gxew91	625	80	of	of	IN
cord-015910-d9gxew91	625	81	transcription	transcription	NN
cord-015910-d9gxew91	625	82	factor	factor	NN
cord-015910-d9gxew91	625	83	NF	nf	NN
cord-015910-d9gxew91	625	84	-	-	HYPH
cord-015910-d9gxew91	625	85	kappa	kappa	NN
cord-015910-d9gxew91	625	86	B	B	NNP
cord-015910-d9gxew91	625	87	and	and	CC
cord-015910-d9gxew91	625	88	p38	p38	CD
cord-015910-d9gxew91	625	89	mitogen	mitogen	NN
cord-015910-d9gxew91	625	90	-	-	HYPH
cord-015910-d9gxew91	625	91	activated	activate	VBN
cord-015910-d9gxew91	625	92	protein	protein	NN
cord-015910-d9gxew91	625	93	kinase	kinase	NN
cord-015910-d9gxew91	625	94	is	be	VBZ
cord-015910-d9gxew91	625	95	mediated	mediate	VBN
cord-015910-d9gxew91	625	96	by	by	IN
cord-015910-d9gxew91	625	97	distinct	distinct	JJ
cord-015910-d9gxew91	625	98	and	and	CC
cord-015910-d9gxew91	625	99	separate	separate	JJ
cord-015910-d9gxew91	625	100	stress	stress	NN
cord-015910-d9gxew91	625	101	effector	effector	NN
cord-015910-d9gxew91	625	102	pathways	pathway	NNS
cord-015910-d9gxew91	625	103	Humoral	Humoral	NNP
cord-015910-d9gxew91	625	104	markers	marker	NNS
cord-015910-d9gxew91	625	105	of	of	IN
cord-015910-d9gxew91	625	106	inflammation	inflammation	NN
cord-015910-d9gxew91	625	107	and	and	CC
cord-015910-d9gxew91	625	108	endothelial	endothelial	JJ
cord-015910-d9gxew91	625	109	dysfunction	dysfunction	NN
cord-015910-d9gxew91	625	110	in	in	IN
cord-015910-d9gxew91	625	111	relation	relation	NN
cord-015910-d9gxew91	625	112	to	to	IN
cord-015910-d9gxew91	625	113	adiposity	adiposity	NN
cord-015910-d9gxew91	625	114	and	and	CC
cord-015910-d9gxew91	625	115	in	in	IN
cord-015910-d9gxew91	625	116	vivo	vivo	NNP
cord-015910-d9gxew91	625	117	insulin	insulin	NN
cord-015910-d9gxew91	625	118	action	action	NN
cord-015910-d9gxew91	625	119	in	in	IN
cord-015910-d9gxew91	625	120	Pima	Pima	NNP
cord-015910-d9gxew91	625	121	Indians	Indians	NNPS
cord-015910-d9gxew91	625	122	Biology	Biology	NNP
cord-015910-d9gxew91	625	123	of	of	IN
cord-015910-d9gxew91	625	124	arterial	arterial	JJ
cord-015910-d9gxew91	625	125	atheroma	atheroma	NNP
cord-015910-d9gxew91	625	126	Comparative	Comparative	NNP
cord-015910-d9gxew91	625	127	genetic	genetic	JJ
cord-015910-d9gxew91	625	128	association	association	NNP
cord-015910-d9gxew91	625	129	of	of	IN
cord-015910-d9gxew91	625	130	human	human	JJ
cord-015910-d9gxew91	625	131	leukocyte	leukocyte	NN
cord-015910-d9gxew91	625	132	antigen	antigen	NNP
cord-015910-d9gxew91	625	133	class	class	NN
cord-015910-d9gxew91	625	134	II	ii	NN
cord-015910-d9gxew91	625	135	and	and	CC
cord-015910-d9gxew91	625	136	tumor	tumor	NN
cord-015910-d9gxew91	625	137	necrosis	necrosis	NN
cord-015910-d9gxew91	625	138	factor	factor	NN
cord-015910-d9gxew91	625	139	-	-	HYPH
cord-015910-d9gxew91	625	140	alpha	alpha	NN
cord-015910-d9gxew91	625	141	with	with	IN
cord-015910-d9gxew91	625	142	dermatitis	dermatitis	NN
cord-015910-d9gxew91	625	143	herpetiformis	herpetiformis	NNP
cord-015910-d9gxew91	626	1	An	an	DT
cord-015910-d9gxew91	626	2	allelic	allelic	JJ
cord-015910-d9gxew91	626	3	polymorphism	polymorphism	NN
cord-015910-d9gxew91	626	4	within	within	IN
cord-015910-d9gxew91	626	5	the	the	DT
cord-015910-d9gxew91	626	6	human	human	JJ
cord-015910-d9gxew91	626	7	tumor	tumor	NN
cord-015910-d9gxew91	626	8	necrosis	necrosis	NN
cord-015910-d9gxew91	626	9	factor	factor	NN
cord-015910-d9gxew91	626	10	alpha	alpha	NN
cord-015910-d9gxew91	626	11	promoter	promoter	NN
cord-015910-d9gxew91	626	12	region	region	NN
cord-015910-d9gxew91	626	13	is	be	VBZ
cord-015910-d9gxew91	626	14	strongly	strongly	RB
cord-015910-d9gxew91	626	15	associated	associate	VBN
cord-015910-d9gxew91	626	16	with	with	IN
cord-015910-d9gxew91	626	17	HLA	HLA	NNP
cord-015910-d9gxew91	626	18	-	-	HYPH
cord-015910-d9gxew91	626	19	A	A	NNP
cord-015910-d9gxew91	626	20	1	1	CD
cord-015910-d9gxew91	626	21	,	,	,
cord-015910-d9gxew91	626	22	B	B	NNP
cord-015910-d9gxew91	626	23	8	8	CD
cord-015910-d9gxew91	626	24	,	,	,
cord-015910-d9gxew91	626	25	and	and	CC
cord-015910-d9gxew91	626	26	DR3	DR3	NNP
cord-015910-d9gxew91	626	27	alleles	allele	NNS
cord-015910-d9gxew91	627	1	A	a	DT
cord-015910-d9gxew91	627	2	genetic	genetic	JJ
cord-015910-d9gxew91	627	3	association	association	NN
cord-015910-d9gxew91	627	4	between	between	IN
cord-015910-d9gxew91	627	5	systemic	systemic	JJ
cord-015910-d9gxew91	627	6	lupus	lupus	NN
cord-015910-d9gxew91	627	7	erythematosus	erythematosus	NN
cord-015910-d9gxew91	627	8	and	and	CC
cord-015910-d9gxew91	627	9	tumor	tumor	NN
cord-015910-d9gxew91	627	10	necrosis	necrosis	NN
cord-015910-d9gxew91	627	11	factor	factor	NN
cord-015910-d9gxew91	627	12	alpha	alpha	NN
cord-015910-d9gxew91	627	13	Effect	effect	NN
cord-015910-d9gxew91	627	14	of	of	IN
cord-015910-d9gxew91	627	15	vitamin	vitamin	NN
cord-015910-d9gxew91	627	16	E	e	NN
cord-015910-d9gxew91	627	17	on	on	IN
cord-015910-d9gxew91	627	18	human	human	JJ
cord-015910-d9gxew91	627	19	aortic	aortic	JJ
cord-015910-d9gxew91	627	20	endothelial	endothelial	JJ
cord-015910-d9gxew91	627	21	cell	cell	NN
cord-015910-d9gxew91	627	22	production	production	NN
cord-015910-d9gxew91	627	23	of	of	IN
cord-015910-d9gxew91	627	24	chemokines	chemokine	NNS
cord-015910-d9gxew91	627	25	and	and	CC
cord-015910-d9gxew91	627	26	adhesion	adhesion	NN
cord-015910-d9gxew91	627	27	to	to	IN
cord-015910-d9gxew91	627	28	monocytes	monocyte	NNS
cord-015910-d9gxew91	627	29	Effect	effect	NN
cord-015910-d9gxew91	627	30	of	of	IN
cord-015910-d9gxew91	627	31	dietary	dietary	JJ
cord-015910-d9gxew91	627	32	supplementation	supplementation	NN
cord-015910-d9gxew91	627	33	with	with	IN
cord-015910-d9gxew91	627	34	fish	fish	NN
cord-015910-d9gxew91	627	35	oil	oil	NN
cord-015910-d9gxew91	627	36	in	in	IN
cord-015910-d9gxew91	627	37	combination	combination	NN
cord-015910-d9gxew91	627	38	with	with	IN
cord-015910-d9gxew91	627	39	different	different	JJ
cord-015910-d9gxew91	627	40	levels	level	NNS
cord-015910-d9gxew91	627	41	of	of	IN
cord-015910-d9gxew91	627	42	vitamin	vitamin	NN
cord-015910-d9gxew91	627	43	E	e	NN
cord-015910-d9gxew91	627	44	on	on	IN
cord-015910-d9gxew91	627	45	immune	immune	JJ
cord-015910-d9gxew91	627	46	response	response	NN
cord-015910-d9gxew91	627	47	in	in	IN
cord-015910-d9gxew91	627	48	healthy	healthy	JJ
cord-015910-d9gxew91	627	49	elderly	elderly	JJ
cord-015910-d9gxew91	627	50	human	human	JJ
cord-015910-d9gxew91	627	51	subjects	subject	NNS
cord-015910-d9gxew91	628	1	In	in	IN
cord-015910-d9gxew91	628	2	vitro	vitro	FW
cord-015910-d9gxew91	628	3	glutathione	glutathione	NN
cord-015910-d9gxew91	628	4	supplementation	supplementation	NN
cord-015910-d9gxew91	628	5	enhances	enhance	VBZ
cord-015910-d9gxew91	628	6	interleukin-2	interleukin-2	IN
cord-015910-d9gxew91	628	7	production	production	NN
cord-015910-d9gxew91	628	8	and	and	CC
cord-015910-d9gxew91	628	9	mitogenic	mitogenic	NNP
cord-015910-d9gxew91	628	10	responses	response	NNS
cord-015910-d9gxew91	628	11	in	in	IN
cord-015910-d9gxew91	628	12	peripheral	peripheral	JJ
cord-015910-d9gxew91	628	13	blood	blood	NN
cord-015910-d9gxew91	628	14	mononuclear	mononuclear	NN
cord-015910-d9gxew91	628	15	cells	cell	NNS
cord-015910-d9gxew91	628	16	from	from	IN
cord-015910-d9gxew91	628	17	young	young	JJ
cord-015910-d9gxew91	628	18	and	and	CC
cord-015910-d9gxew91	628	19	old	old	JJ
cord-015910-d9gxew91	628	20	subjects	subject	NNS
cord-015910-d9gxew91	628	21	Associations	association	NNS
cord-015910-d9gxew91	628	22	of	of	IN
cord-015910-d9gxew91	628	23	serum	serum	NN
cord-015910-d9gxew91	628	24	C	c	NN
cord-015910-d9gxew91	628	25	-	-	HYPH
cord-015910-d9gxew91	628	26	reactive	reactive	JJ
cord-015910-d9gxew91	628	27	protein	protein	NN
cord-015910-d9gxew91	628	28	with	with	IN
cord-015910-d9gxew91	628	29	fasting	fast	VBG
cord-015910-d9gxew91	628	30	insulin	insulin	NN
cord-015910-d9gxew91	628	31	,	,	,
cord-015910-d9gxew91	628	32	glucose	glucose	NN
cord-015910-d9gxew91	628	33	,	,	,
cord-015910-d9gxew91	628	34	and	and	CC
cord-015910-d9gxew91	628	35	glycosylated	glycosylated	JJ
cord-015910-d9gxew91	628	36	hemoglobin	hemoglobin	NN
cord-015910-d9gxew91	628	37	:	:	:
cord-015910-d9gxew91	629	1	The	the	DT
cord-015910-d9gxew91	629	2	Third	Third	NNP
cord-015910-d9gxew91	629	3	National	National	NNP
cord-015910-d9gxew91	629	4	Health	Health	NNP
cord-015910-d9gxew91	629	5	and	and	CC
cord-015910-d9gxew91	629	6	Nutrition	Nutrition	NNP
cord-015910-d9gxew91	629	7	Examination	Examination	NNP
cord-015910-d9gxew91	629	8	Survey	Survey	NNP
cord-015910-d9gxew91	629	9	Production	Production	NNP
cord-015910-d9gxew91	629	10	of	of	IN
cord-015910-d9gxew91	629	11	tumour	tumour	NN
cord-015910-d9gxew91	629	12	necrosis	necrosis	NN
cord-015910-d9gxew91	629	13	factor	factor	NN
cord-015910-d9gxew91	629	14	--	--	:
cord-015910-d9gxew91	629	15	alpha	alpha	NN
cord-015910-d9gxew91	629	16	increases	increase	NNS
cord-015910-d9gxew91	629	17	with	with	IN
cord-015910-d9gxew91	629	18	age	age	NN
cord-015910-d9gxew91	629	19	and	and	CC
cord-015910-d9gxew91	629	20	BMI	bmi	NN
cord-015910-d9gxew91	629	21	in	in	IN
cord-015910-d9gxew91	629	22	healthy	healthy	JJ
cord-015910-d9gxew91	629	23	women	woman	NNS
cord-015910-d9gxew91	630	1	The	the	DT
cord-015910-d9gxew91	630	2	influence	influence	NN
cord-015910-d9gxew91	630	3	of	of	IN
cord-015910-d9gxew91	630	4	age	age	NN
cord-015910-d9gxew91	630	5	and	and	CC
cord-015910-d9gxew91	630	6	gender	gender	NN
cord-015910-d9gxew91	630	7	on	on	IN
cord-015910-d9gxew91	630	8	serum	serum	NN
cord-015910-d9gxew91	630	9	dehydroepiaandrosterone	dehydroepiaandrosterone	NN
cord-015910-d9gxew91	630	10	sulphate	sulphate	NN
cord-015910-d9gxew91	630	11	(	(	-LRB-
cord-015910-d9gxew91	630	12	DHEA	DHEA	NNP
cord-015910-d9gxew91	630	13	-	-	HYPH
cord-015910-d9gxew91	630	14	S	S	NNP
cord-015910-d9gxew91	630	15	)	)	-RRB-
cord-015910-d9gxew91	630	16	,	,	,
cord-015910-d9gxew91	630	17	IL-6	IL-6	NNP
cord-015910-d9gxew91	630	18	,	,	,
cord-015910-d9gxew91	630	19	IL-6	IL-6	NNP
cord-015910-d9gxew91	630	20	soluble	soluble	JJ
cord-015910-d9gxew91	630	21	receptor	receptor	NN
cord-015910-d9gxew91	630	22	(	(	-LRB-
cord-015910-d9gxew91	630	23	IL-6	IL-6	NNP
cord-015910-d9gxew91	630	24	sR	sR	NNP
cord-015910-d9gxew91	630	25	)	)	-RRB-
cord-015910-d9gxew91	630	26	and	and	CC
cord-015910-d9gxew91	630	27	transforming	transform	VBG
cord-015910-d9gxew91	630	28	growth	growth	NN
cord-015910-d9gxew91	630	29	factor	factor	NN
cord-015910-d9gxew91	630	30	beta	beta	NN
cord-015910-d9gxew91	630	31	1	1	CD
cord-015910-d9gxew91	630	32	(	(	-LRB-
cord-015910-d9gxew91	630	33	TGF	TGF	NNP
cord-015910-d9gxew91	630	34	-	-	HYPH
cord-015910-d9gxew91	630	35	beta	beta	NN
cord-015910-d9gxew91	630	36	1	1	CD
cord-015910-d9gxew91	630	37	)	)	-RRB-
cord-015910-d9gxew91	630	38	levels	level	NNS
cord-015910-d9gxew91	630	39	in	in	IN
cord-015910-d9gxew91	630	40	normal	normal	JJ
cord-015910-d9gxew91	630	41	healthy	healthy	JJ
cord-015910-d9gxew91	630	42	blood	blood	NN
cord-015910-d9gxew91	630	43	donors	donor	NNS
cord-015910-d9gxew91	630	44	Polymorphisms	Polymorphisms	NNPS
cord-015910-d9gxew91	630	45	in	in	IN
cord-015910-d9gxew91	630	46	the	the	DT
cord-015910-d9gxew91	630	47	promoter	promoter	NN
cord-015910-d9gxew91	630	48	of	of	IN
cord-015910-d9gxew91	630	49	the	the	DT
cord-015910-d9gxew91	630	50	tumor	tumor	NN
cord-015910-d9gxew91	630	51	necrosis	necrosis	NN
cord-015910-d9gxew91	630	52	factor	factor	NN
cord-015910-d9gxew91	630	53	-	-	HYPH
cord-015910-d9gxew91	630	54	alpha	alpha	NN
cord-015910-d9gxew91	630	55	gene	gene	NN
cord-015910-d9gxew91	630	56	in	in	IN
cord-015910-d9gxew91	630	57	coal	coal	NN
cord-015910-d9gxew91	630	58	miners	miner	NNS
cord-015910-d9gxew91	630	59	Reduction	reduction	NN
cord-015910-d9gxew91	630	60	of	of	IN
cord-015910-d9gxew91	630	61	inflammatory	inflammatory	JJ
cord-015910-d9gxew91	630	62	cytokine	cytokine	NN
cord-015910-d9gxew91	630	63	concentrations	concentration	NNS
cord-015910-d9gxew91	630	64	and	and	CC
cord-015910-d9gxew91	630	65	improvement	improvement	NN
cord-015910-d9gxew91	630	66	of	of	IN
cord-015910-d9gxew91	630	67	endothelial	endothelial	JJ
cord-015910-d9gxew91	630	68	functions	function	NNS
cord-015910-d9gxew91	630	69	in	in	IN
cord-015910-d9gxew91	630	70	obese	obese	JJ
cord-015910-d9gxew91	630	71	women	woman	NNS
cord-015910-d9gxew91	630	72	after	after	IN
cord-015910-d9gxew91	630	73	weight	weight	NN
cord-015910-d9gxew91	630	74	loss	loss	NN
cord-015910-d9gxew91	630	75	over	over	IN
cord-015910-d9gxew91	630	76	one	one	CD
cord-015910-d9gxew91	630	77	year	year	NN
cord-015910-d9gxew91	631	1	The	the	DT
cord-015910-d9gxew91	631	2	author	author	NN
cord-015910-d9gxew91	631	3	is	be	VBZ
cord-015910-d9gxew91	631	4	grateful	grateful	JJ
cord-015910-d9gxew91	631	5	to	to	IN
cord-015910-d9gxew91	631	6	the	the	DT
cord-015910-d9gxew91	631	7	BBSRC	BBSRC	NNP
cord-015910-d9gxew91	631	8	for	for	IN
cord-015910-d9gxew91	631	9	funding	fund	VBG
cord-015910-d9gxew91	631	10	much	much	JJ
cord-015910-d9gxew91	631	11	of	of	IN
cord-015910-d9gxew91	631	12	the	the	DT
cord-015910-d9gxew91	631	13	work	work	NN
cord-015910-d9gxew91	631	14	reported	report	VBN
cord-015910-d9gxew91	631	15	in	in	IN
cord-015910-d9gxew91	631	16	this	this	DT
cord-015910-d9gxew91	631	17	chapter	chapter	NN
cord-015910-d9gxew91	631	18	.	.	.
cord-015910-d9gxew91	632	1	The	the	DT
cord-015910-d9gxew91	632	2	author	author	NN
cord-015910-d9gxew91	632	3	is	be	VBZ
cord-015910-d9gxew91	632	4	also	also	RB
cord-015910-d9gxew91	632	5	grateful	grateful	JJ
cord-015910-d9gxew91	632	6	to	to	IN
cord-015910-d9gxew91	632	7	collegues	collegue	NNS
cord-015910-d9gxew91	632	8	in	in	IN
cord-015910-d9gxew91	632	9	the	the	DT
cord-015910-d9gxew91	632	10	United	United	NNP
cord-015910-d9gxew91	632	11	Kingdom	Kingdom	NNP
cord-015910-d9gxew91	632	12	,	,	,
cord-015910-d9gxew91	632	13	Sweden	Sweden	NNP
cord-015910-d9gxew91	632	14	,	,	,
cord-015910-d9gxew91	632	15	and	and	CC
cord-015910-d9gxew91	632	16	Switzerland	Switzerland	NNP
cord-015910-d9gxew91	632	17	for	for	IN
cord-015910-d9gxew91	632	18	scientific	scientific	JJ
cord-015910-d9gxew91	632	19	collaboration	collaboration	NN
cord-015910-d9gxew91	632	20	and	and	CC
cord-015910-d9gxew91	632	21	advice	advice	NN
cord-015910-d9gxew91	632	22	.	.	.